bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative evidence synthesis: a practical guide on meta-analysis, meta-regression, and publication bias tests for environmental sciences
Authors: Nakagawa Shinichi , Yang Yefeng , Macartney Erin L. , Spake Rebecca , Lagisz Malgorzata 
Published: April 2023

AbstractMeta-analysis is a quantitative way of synthesizing results from multiple studies to obtain reliable evidence of an intervention or phenomenon. Indeed, an increasing number of meta-analyses are conducted in environmental sciences, and resulting meta-analytic evidence is often used in environmental policies and decision-making. We conducted a survey of recent meta-analyses in environmental sciences and found poor standards of current meta-analytic practice and reporting. For example, only ~ 40% of the 73 reviewed meta-analyses reported heterogeneity (variation among effect sizes beyond sampling error), and publication bias was assessed in fewer than half. Furthermore, although almost all the meta-analyses had multiple effect sizes originating from the same studies, non-independence among effect sizes was considered in only half of the meta-analyses. To improve the implementation of meta-analysis in environmental sciences, we here outline practical guidance for conducting a meta-analysis in environmental sciences. We describe the key concepts of effect size and meta-analysis and detail procedures for fitting multilevel meta-analysis and meta-regression models and performing associated publication bias tests. We demonstrate a clear need for environmental scientists to embrace multilevel meta-analytic models, which explicitly model dependence among effect sizes, rather than the commonly used random-effects models. Further, we discuss how reporting and visual presentations of meta-analytic results can be much improved by following reporting guidelines such as PRISMA-EcoEvo (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Ecology and Evolutionary Biology). This paper, along with the accompanying online tutorial, serves as a practical guide on conducting a complete set of meta-analytic procedures (i.e., meta-analysis, heterogeneity quantification, meta-regression, publication bias tests and sensitivity analysis) and also as a gateway to more advanced, yet appropriate, methods.
Canadian multidisciplinary expert consensus on the use of biologics in upper airways: A Delphi study
Authors: Thamboo Andrew V. , Lee Melissa , Bhutani Mohit , Chan Charles , Chan Yvonne , Chapman Ken R. , Chin Christopher J. , Connors Lori , Dorscheid Del , Ellis Anne K. , Gall Richard M. , Godbout Krystelle , Janjua Arif , Javer Amin , Kilty Shaun , Kim Harold , Kirkpatrick Gordon , Lee John M. , Leigh Richard , Lemiere Catherine , Monteiro Eric , Neighbour Helen , Keith Paul K. , Philteos George , Quirt Jaclyn , Rotenberg Brian , Ruiz Juan C. , Scott John R. , Sommer Doron D. , Sowerby Leigh , Tewfik Marc , Waserman Susan , Witterick Ian , Wright Erin D. , Yamashita Cory , Desrosiers Martin 
Published: April 2023

Background Chronic rhinosinusitis with nasal polyposis (CRSwNP) often coexists with lower airway disease. With the overlap between upper and lower airway disease, optimal management of the upper airways is undertaken in conjunction with that of the lower airways. Biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve the clinical signs and symptoms of both upper and lower airway diseases. Knowledge gaps nevertheless exist in how best to approach patient care as a whole. There have been sixteen randomized, double-blind, placebo-controlled trails performed for CRSwNP targeted components of the Type 2 inflammatory pathway, notably interleukin (IL)-4, IL-5 and IL-13, IL- 5R, IL-33, and immunoglobulin (Ig)E. This white paper considers the perspectives of experts in various disciplines such as rhinology, allergy, and respirology across Canada, all of whom have unique and valuable insights to contribute on how to best approach patients with upper airway disease from a multidisciplinary perspective. Methods A Delphi Method process was utilized involving three rounds of questionnaires in which the first two were completed individually online and the third was discussed on a virtual platform with all the panelists. A national multidisciplinary expert panel of 34 certified specialists was created, composed of 16 rhinologists, 7 allergists, and 11 respirologists who evaluated the 20 original statements on a scale of 1–9 and provided comments. All ratings were quantitively reviewed by mean, median, mode, range, standard deviation and inter-rater reliability. Consensus was defined by relative interrater reliability measures—kappa coefficient ([Formula: see text] [Formula: see text]) value > 0.61. Results After three rounds, a total of 22 statements achieved consensus. This white paper only contains the final agreed upon statements and clear rationale and support for the statements regarding the use of biologics in patients with upper airway disease. Conclusion This white paper provides guidance to Canadian physicians on the use of biologic therapy for the management of upper airway disease from a multidisciplinary perspective, but the medical and surgical regimen should ultimately be individualized to the patient. As more biologics become available and additional trials are published we will provide updated versions of this white paper every few years. Graphical Abstract
Absence of Cretaceous hairpin in the apparent polar wander path of southwest Japan: consistency in paleomagnetic pole positions
Authors: Uno Koji , Ohara Honoka , Furukawa Kuniyuki , Kanamaru Tatsuo 
Published: April 2023

AbstractTo test the hypothesis that a Cretaceous hairpin turn is absent in the apparent polar wander path (APWP) of the inner arc of southwestern Japanese island (southwest Japan), we refined a mid-Cretaceous (100 Ma) paleomagnetic pole from southwest Japan. Red mudstone samples from the 100 Ma Hayama Formation were collected for paleomagnetic analysis from eight sites in the Hayama area in the central part of southwest Japan. A high-temperature remanent magnetization component carried by hematite was isolated from these sites and was found to be of primary mid-Cretaceous origin. The primary nature of the magnetization is supported by the detrital character of the magnetic carrier. The primary directions provided a paleomagnetic pole (35.0°N, 209.6°E, A95 = 6.1°, N = 8), which represented southwest Japan at 100 Ma. This pole falls into a cluster of Cretaceous poles in southwest Japan. An APWP for southwest Japan between 110 and 70 Ma was updated to ascertain the stationarity of the pole positions for this region. Therefore, it is unlikely that the APWP for southwest Japan experienced a hairpin turn during the Cretaceous.
Undergraduate student perceptions of stress and mental health in engineering culture
Authors: Jensen Karin J. , Mirabelli Joseph F. , Kunze Andrea J. , Romanchek Thomas E. , Cross Kelly J. 
Published: April 2023

AbstractBackgroundMental health for engineering undergraduates is an urgent topic for engineering educators. Narratives of engineering education requiring suffering may create or exacerbate problematic perceptions around stress and mental health in engineering. This study explored the roles of stress and mental health in engineering culture. We sought to explore: (1) how engineering students describe their experiences related to stress and mental health and (2) norms and expectations engineering students share about stress and mental health. Qualitative interview data were collected from 30 students who had previously responded to a college-wide survey.ResultsCodes related to experiences with stress and mental health in engineering were organized in a bioecological systems model and analyzed for emergent themes depicting engineering culture. The study identified three themes related to stress and mental health in engineering culture: (1) engineering workload as a defining stressor, (2) specific barriers that prevent engineering students from seeking help for mental health concerns, and (3) reliance on peers to cope with stress and mental health distress.ConclusionsOur analysis provided insight into how engineering students perceive norms around stress and mental health in engineering and how this impacts help-seeking for mental health challenges. These findings have important implications for developing interventions and positive cultures that support student mental health.
Improved heating method for shape-memory alloy using carbon nanotube and silver paste
Authors: Kim Sang Jin , Kim Sang Un , Vu Chi Cuong , Kim Joo Yong 
Published: April 2023

AbstractShape memory alloys (SMAs) have a special ability to remember their initial shape and return from operating temperature. For this special ability, there are many studies in the field of smart wearables to replace rigid, heavy, and large electric actuators with SMAs that can be a fabrication. The usual operating method of the SMA is heating the SMA by direct Joule heating with electricity. Although direct Joule heating is fast and easy, there is overshooting, unstable, and high-power consumption. For these issues to use the SMA as textile actuators, this research suggested a heating method with silver paste required lower power consumption and coating the basic fabric with carbon nanotubes (CNTs) to support heating stability and heat uniformity. The heating method evaluated the efficiency of heat by comparing direct heating and silver layer heating and the uniformity of heat with the infrared images of whether CNTs coated or not. In this research, we reached higher temperatures with lower power than direct Joule heating using wearable heaters manufactured using silver paste. In addition, we confirmed that coating the basic fabric with carbon nanotubes reduce the temperature imbalance, and improved the heating stability. This research is expected that SMA will be used as a wearable actuator to help develop wearable devices that can move.
Regional and socioeconomic inequalities in access to pre-primary education in India: evidence from a recent household survey
Authors: Choudhury Pradeep Kumar , Joshi Radhika , Kumar Amit 
Published: April 2023

AbstractIn India, the National Education Policy 2020 recommends ensuring universal access to high-quality early childhood care and education for children aged 3–6 years by 2030. Using the 75th round of National Statistical Office data (2017–2018), this paper analyses the regional and socioeconomic inequalities in access to pre-primary education. Also, we investigate the specific role of households’ economic status and educational attainment in explaining these inequalities. We find considerable regional (rural/urban) and socioeconomic inequalities in access to pre-primary education in India, with girls and children belonging to historically disadvantaged social groups (scheduled castes and scheduled tribes) less likely to attend early childhood education, particularly in rural areas. We find that a substantial portion of the rural–urban gap in access to pre-primary education can be removed by controls for households’ economic condition and household head’s educational status. In addition, we find gender and socioeconomic inequalities in the household investment in early years education. These findings highlight the need to put policy efforts and commitments to reducing barriers to accessing pre-primary education for children in disadvantaged conditions in India.
Site-specific 68Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models
Authors: Dewulf Jonatan , Flieswasser Tal , Delahaye Tim , Vangestel Christel , Miranda Alan , de Haard Hans , Jacobs Julie , Smits Evelien , Van den Wyngaert Tim , Elvas Filipe 
Published: April 2023

Abstract
Background
CD70-CD27 is a costimulatory ligand-receptor pair in the tumor necrosis factor receptor family. With only limited expression in normal tissues, CD70 is constitutively expressed in a variety of solid tumors and hematologic malignancies, facilitating immunosuppression through CD27 signaling in the tumor microenvironment by enhanced survival of regulatory T cells, induction of T cell apoptosis, and T cell exhaustion. Consequently, CD70 is an increasingly recognized target for developing antibody-based therapies, but its expression patterns vary among different tumor types in spatial distribution, magnitude of expression and percentage of positive cells. In that regard, individual confirmation of CD70 expression at screening and during treatment could enhance the successful implementation of anti-CD70 therapies. Here, we developed a gallium-68 (68Ga) radiolabeled single-domain antibody-fragment targeting CD70 for in vivo positron emission tomography (PET) imaging.

Results
An anti-CD70 VHH construct containing a C-direct-tag with a free thiol was developed to enable site-specific conjugation to a NOTA bifunctional chelator for 68Ga radiolabeling. [68Ga]Ga-NOTA-anti-CD70 VHH was obtained in good radiochemical yield of 30.4 ± 1.7% and high radiochemical purity (> 94%). The radiolabeled VHH showed excellent in vitro and in vivo stability. Specific binding of [68Ga]Ga-NOTA-anti-CD70 VHH was observed on CD70high 786-O cells, showing significantly higher cell-associated activity when compared to the blocking condition (p < 0.0001) and CD70low NCl-H1975 cells (p < 0.0001). PET imaging showed specific radiotracer accumulation in CD70 expressing human tumor xenografts, which was efficiently blocked by prior injection of unlabeled anti-CD70 VHH (p = 0.0029). In addition, radiotracer uptake in CD70high tumors was significantly higher when compared with CD70low tumors (p < 0.0001). The distribution of the radioactivity in the tumors using autoradiography was spatially matched with immunohistochemistry analysis of CD70 expression.

Conclusion
[68Ga]Ga-NOTA-anti-CD70 VHH showed excellent in vivo targeting of CD70 in human cancer xenografts. PET imaging using this radioimmunoconjugate holds promise as a non-invasive method to identify and longitudinally follow-up patients who will benefit most from anti-CD70 therapies.
Comparison of gadolinium-based contrast agents for MR cholangiography in saline, blood and bile: a phantom study
Authors: Froehlich Johannes M. , Moussa Leen , Guirguis Natalie , Gutzeit Andreas , Wu David , Sartoretti-Schefer Sabine , Koh Dow-Mu , Kolokythas Orpheus , Matoori Simon 
Published: April 2023

Abstract
Background
We compared T1- and T2-weighted signal intensities of liver-specific (gadoxetate, gadobenate) and non-specific (gadoterate) gadolinium contrast agents (CAs) in a bile phantom.

Methods
In a phantom study, gadoxetate, gadobenate, and gadoterate were diluted in saline, blood, and bile at different concentrations (0, 0.25, 0.5. 1, 2.5, 5, 10, and 25 mM) and imaged in a 3-T magnetic resonance imaging (MRI) system using T1- and T2-weighted sequences. The maximum signal intensities of CAs were compared for each sequence separately and across all T1-weighted sequences using one-way ANOVA.

Results
Using T1-weighted sequences, CA concentration-dependent signal intensity increase was followed by decrease due to T2* effects. Comparing CAs for each sequence in bile yielded higher maximum signal intensities with gadobenate than gadoxetate and gadoterate using T1-weighted spin-echo (p < 0.010), multiecho gradient- and spin-echo (p < 0.001), and T1-weighted high-resolution isotropic volume excitation (eTHRIVE) sequences (p < 0.010). Comparing across all T1-weighted sequences in the bile phantom, gadobenate imaged using T1-weighted turbo field-echo (TFE) sequence showed the highest signal intensity, significantly higher than that using other CAs agents or sequences (p < 0.004) except for gadobenate and gadoxetate evaluated with three-dimensional multiecho fast field-echo (3D-mFFE) and gadoxetate with T1-weighted TFE sequence (p > 0.141). Signal reduction with CA concentration-dependent decrease was observed on T2-weighted images.

Conclusion
In this bile phantom study of gadolinium-based CA, gadobenate and gadoxetate showed high signal intensity with T1-weighted TFE and 3D-mFFE sequences, which supports their potential utility for contrast-enhanced hepatobiliary MRI.

Key points
• Contrast-enhanced magnetic resonance (MR) cholangiography depends on contrast agent type, kinetics, and concentration in bile,
• We compared signal intensities of three contrast agents in a bile phantom study.
• Gadobenate, gadoxetate, and gadoterate demonstrated different signal intensities at identical concentrations.
• Gadoxetate and gadobenate showed high signal intensities on T1-weighted MR sequences.
Cognitive dysfunction in patients with childhood-onset systemic lupus erythematosus may impact treatment
Authors: Teixeira Santos Flávia Patrícia Sena , Ferreira Gilda Aparecida , de Paula Jonas Jadim , de Souza Kalline Cristina Prata , Cançado Silva Sandro Luiz , Correa Humberto 
Published: April 2023

Abstract
Background
Cognitive dysfunction (CD) is a widespread manifestation in adult systemic lupus erythematosus (SLE) patients, but this subject is rarely examined in patients with childhood-onset SLE (cSLE). This study aimed to assess the frequency of CD, its associations with lupus clinical manifestations and its impact on the health-related quality of life (HRQL) in young adult cSLE patients.

Methods
We evaluated 39 cSLE patients older than 18 years. They underwent a rheumatologic evaluation and extensive neuropsychological assessment, encompassing all cognitive domains described by the American College of Rheumatology. HRQL was assessed with the WHOOQOL-BREEF, General Activities of Daily Living Scale (GADL) and Systemic Lupus Erythematosus-specific quality-of-life instrument (SLEQOL). The activity of SLE was evaluated with the modified sle disease activity index (sledai-2k).

Results
Impairment in at least one cognitive domain was found in 35 (87.2%) patients. The most compromised domains were attention (64.1%), memory (46.2%), and executive functions (38.5%). Patients with cognitive impairment were older, had more accumulated damage and had worse socioeconomic status. Regarding the association between cognitive dysfunction and HRQL, memory impairment was correlated with worse environmental perception and a worse relationship with the treatment.

Conclusion
In this study, the frequency of CD in cSLE patients was as high as that in the adult SLE population. CD can significantly impact the response of cSLE patients to treatment, justifying preventive measures in the care of this population.
Simulation and optimization of scrap wagon dismantling system based on Plant Simulation
Authors: Chen Hai-Qing , Dong Yu-De , Hu Fei , Liu Ming-Ming , Zhang Shi-Bao 
Published: April 2023

AbstractBased on the existing plant layout and process flow, a simulation analysis was conducted using the Plant Simulation platform with the utilization efficiency of each station and production capacity of the dismantling system as indicators. A problem with long-term suspension in the disassembly process was determined. Based on the two optimization directions of increasing material transportation equipment and expanding the buffer capacity, a cost-oriented optimization model is established. A genetic algorithm and model simulation were used to solve the model. An optimization scheme that satisfies the production needs and has the lowest cost is proposed. The results show that the optimized dismantling system solves the suspended work problem at the dismantling station and a significant improvement in productivity and station utilization efficiency compared with the previous system.
Characterization of fruit production and market performance in northwest Ethiopia
Authors: Mossie Mengistie , Gerezgiher Alemseged , Ayalew Zemen , Nigussie Zerihun , Elias Asres 
Published: April 2023

Abstract
Background
In Ethiopia, fruits pose a significant production and marketing challenge for farm households that significantly affect their farm profitability due to their perishability and unpredictable seasonal pricing. For instance, seasonally, market prices vary depending on the quality and quantity of fruit products available on the market. Stemming from this logical ground, this study is initiated with the objective of characterizing production systems and market performance of fruits in Ethiopia, focusing on apple and mango crops.

Methods
A random sampling approach was used for producers and snowball sampling for traders when selecting survey participants. A pre-tested survey questionnaire was used for data collection. Descriptive statistics and market margins were used for statistical analysis.

Results
Post-harvest wastage is preventing farmers from receiving anticipated revenue, implying that approximately 31.8 and 26.1% of the total mango and apple produce was lost, respectively. According to the survey results, there was no measurement consistency among farmers, local collectors, and small retailers. District level collectors received a higher margin share (42.66 and 40.18% of apple and mango, respectively) than other actors in the chain, which was unjustified given their contribution to the market chain. Farmers were comparatively hampered by the market since they earned the lowest share (33.34 and 15.08% of apple and mango, respectively) of consumer prices indicating that the apple and mango market chain performance is poor. As a consequence, these all deter farmers from producing in large quantities, quality, and also uncertainty (fair failure in the mind of farmers) in the marketing of apples and mangoes.

Conclusions
The awareness of small-scale farmers about most of the agronomic practices including insect pests and diseases were very low. Hence, this study recommended that there is an urgent need from district agricultural offices to improve mango and apple production and marketing systems in the study districts.
Pathways to eating disorder care: A European multicenter study
Authors: Monteleone Alessio Maria , Barone Eugenia , Cascino Giammarco , Schmidt Ulrike , Gorwood Philip , Volpe Umberto , Abbate-Daga Giovanni , Castellini Giovanni , Díaz Marsá Marina , Favaro Angela , Fukutomi Akira , Guillaume Sebastien , Minařík Petr , Pacheco José Antonio Soriano , Panero Matteo , Papežová Hana , Ricca Valdo , Segura-Garcia Cristina , Scanferla Elisabetta , Tyszkiewicz-Nwafor Marta , Fernandez-Aranda Fernando , Voderholzer Ulrich , Treasure Janet , Monteleone Palmiero 
Published: April 2023

Abstract

Background
The aim of this study was to assess barriers and facilitators in the pathways toward specialist care for eating disorders (EDs).

Methods
Eleven ED services located in seven European countries recruited patients with an ED. Clinicians administered an adapted version of the World Health Organization “Encounter Form,” a standardized tool to assess the pathways to care. The unadjusted overall time needed to access the ED unit was described using the Kaplan–Meier curve.

Results
Four-hundred-nine patients were recruited. The median time between the onset of the current ED episode and the access to a specialized ED care was 2 years. Most of the participants did not directly access the specialist ED unit: primary “points of access” to care were mental health professionals and general practitioners. The involvement of different health professionals in the pathway, seeking help for general psychiatric symptoms, and lack of support from family members were associated with delayed access to ED units.

Conclusions
Educational programs aiming to promote early diagnosis and treatment for EDs should pay particular attention to general practitioners, in addition to mental health professionals, and family members to increase awareness of these illnesses and of their treatment initiation process.