bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proposed new Japanese classification of synchronous peritoneal metastases from colorectal cancer: A multi‐institutional, prospective, observational study conducted by the Japanese Society for Cancer of the Colon and Rectum
Authors: Kobayashi Hirotoshi , Kotake Kenjiro , Kawasaki Masayasu , Kanemitsu Yukihide , Kinugasa Yusuke , Ueno Hideki , Maeda Kotaro , Suto Takeshi , Itabashi Michio , Funahashi Kimihiko , Ozawa Heita , Koyama Fumikazu , Noura Shingo , Ishida Hideyuki , Ohue Masayuki , Kiyomatsu Tomomichi , Ishihara Soichiro , Koda Keiji , Baba Hideo , Kawada Kenji , Hashiguchi Yojiro , Goi Takanori , Toiyama Yuji , Tomita Naohiro , Sunami Eiji , Akagi Yoshito , Watanabe Jun , Hakamada Kenichi , Nakayama Goro , Sugihara Kenichi , Ajioka Yoichi 
Published: April 2023

AbstractAimTo establish a new Japanese classification of synchronous peritoneal metastases from colorectal cancer.MethodsThis multi‐institutional, prospective, observational study enrolled patients who underwent surgery for colorectal cancer with synchronous peritoneal metastases. Overall survival rates were compared according to the various models using objective indicators. Each model was evaluated by Akaike's information criterion (AIC). The region of peritoneal metastases was evaluated by the peritoneal cancer index (PCI).ResultsBetween October 2012 and December 2016, 150 patients were enrolled. The AIC of the present Japanese classification was 1020.7. P1 metastasis was defined as confined to two regions. The minimum AIC was obtained with the cutoff number of 10 or less for P2 metastasis and 11 or more for P3 metastasis. As for size, the best discrimination ability between P2 and P3 metastasis was obtained with a cutoff value of 3 cm. The AIC of the proposed classification was 1014.7. The classification was as follows: P0, no peritoneal metastases; P1, metastases localized to adjacent peritoneum (within two regions of PCI); P2, metastases to distant peritoneum, number ≤10 and size ≤3 cm; P3, metastases to distant peritoneum, number ≥11 or size >3 cm; P3a, metastases to distant peritoneum, number ≥11 and size ≤3 cm, or number ≤10 and size >3 cm; P3b, metastases to distant peritoneum, number ≥11 and size >3 cm.ConclusionThis objective classification could improve the ability to discriminate prognosis in patients with synchronous peritoneal metastases from colorectal cancer.
Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma
Authors: Shimagaki Tomonari , Sugimachi Keishi , Mano Yohei , Onishi Emi , Iguchi Tomohiro , Nakashima Yuichiro , Sugiyama Masahiko , Yamamoto Manabu , Morita Masaru , Toh Yasushi 
Published: April 2023

AbstractAimThis study was performed to investigate the relationship between the preoperative cachexia index (CXI) and long‐term outcomes in patients who have undergone radical resection of pancreatic ductal adenocarcinoma (PDAC).MethodsIn total, 144 patients who underwent pancreatic resection for treatment of PDAC were retrospectively analyzed. The relationship between the CXI and the patients' long‐term outcomes after PDAC resection was investigated. The CXI was calculated based on the preoperative skeletal muscle index, serum albumin level, and neutrophil‐to‐lymphocyte ratio. After propensity‐score matching, we compared clinicopathological features and outcomes.ResultsThe multivariate analysis showed that lymph node metastasis (hazard ratio [HR], 1.93; 95% confidence interval [CI], 1.16–3.23; P = 0.0118), R1 resection (HR, 57.20; 95% CI, 9.39–348.30; P < 0.0001), and a low CXI (HR, 2.10; 95% CI, 1.27–3.46; P = 0.0038) were independent and significant predictors of disease‐free survival (DFS) after PDAC resection. Moreover, a low CXI (HR, 3.14; 95% CI, 1.71–5.75; P = 0.0002) was an independent and significant predictor of overall survival (OS) after PDAC resection. After propensity‐score matching, the low CXI group had a significantly worse prognosis than the high CXI group for both DFS and OS.ConclusionThe CXI can be a useful prognostic factor for DFS and OS after pancreatic resection for treatment of PDAC.
Localized Ligands Assist Ultrafast Multivalent‐Cation Intercalation Pseudocapacitance
Authors: Xie Luting , Xu Kui , Sun Wenlu , Fan Yingzhu , Zhang Junyu , Zhang Yixiao , Zhang Hui , Chen Jun , Shen Yanbin , Fu Fang , Kong Huabin , Wu Guan , Wu Jihuai , Chen Liwei , Chen Hongwei 
Published: April 2023

AbstractRechargeable batteries based on multivalent cation (Mvn+, n>1) carriers are considered potentially low‐cost alternatives to lithium‐ion batteries. However, the high charge‐density Mvn+ carriers generally lead to sluggish kinetics and poor structural stability in cathode materials. Herein, we report an Mvn+ storage via intercalation pseudocapacitance mechanism in a 2D bivalve‐like organic framework featured with localized ligands. By switching from conventional intercalation to localized ligand‐assisted‐intercalation pseudocapacitance, the organic cathode exhibits unprecedented fast kinetics with little structural change upon intercalation. It thus enables an excellent power density of 57 kW kg−1 over 20000 cycles for Ca2+ storage and a power density of 14 kW kg−1 with a long cycling life over 45000 cycles for Zn2+ storage. This work may provide a largely unexploited route toward constructing a local dynamic coordination microstructure for ultrafast Mvn+ storage.
Formal Insertion of Alkenes Into C(sp3)−F Bonds Mediated by Fluorine‐Hydrogen Bonding
Authors: Garg Arushi , Gerwien Nils J. , Fasting Carlo , Charlton Alex , Hopkinson Matthew N. 
Published: April 2023

AbstractC−F Insertion reactions represent an attractive approach to prepare valuable fluorinated compounds. The high strength of C−F bonds and the low reactivity of the fluoride released upon C−F bond cleavage, however, mean that examples of such processes are extremely scarce in the literature. Here we report a reaction system that overcomes these challenges using hydrogen bond donors that both activate C−F bonds and allow for downstream reactions with fluoride. In the presence of hexafluoroisopropanol, benzyl and propargyl fluorides undergo efficient formal C−F bond insertion across α‐fluorinated styrenes. This process, which does not require any additional fluorinating reagent, occurs under mild conditions and delivers products featuring the gem‐difluoro motif, which is attracting increasing interest in medicinal chemistry. Moreover, readily available organic bromides can be engaged directly in a one‐pot process that avoids the isolation of organic fluorides.
Electrical Control of Exciton Diffusion via Tuning Exciton States
Authors: Chen Yingying , Yao Wendian , Liu Zeyi , Hu Junchao , Li Junze , Li Dehui 
Published: April 2023

AbstractStacking of monolayer 2D transition metal dichalcogenides (TMDs) into van der Waals heterostructures can enable the formation of interlayer excitons (IXs) with long lifetimes and permanent out‐of‐plane electric dipoles, allowing them to propagate over long distances. While early studies on TMD heterobilayrs show efficient electrical control of excitonic transport of IXs by creating different energy potentials, the electrically controllable exciton states and associated spatial migration remain elusive. Here, an electrical control of exciton diffusion through the change of exciton states between charged IXs (CIXs) and charged intralayer excitons is reported. The repulsive dipolar interaction of IXs accounts for the growing exciton cloud size and increasing diffusion length in the power‐dependent PL study. More importantly, the electrically tunable spatial exciton distribution is demonstrated by switching the exciton states, which shows a 1.5‐fold change in diffusion length and an order of magnitude increase in lifetime from charged intralayer excitons to CIXs. The electrical control of exciton states and the relevant diffusion dynamics provide another knob to study the interplay between propagation and many‐body interactions for the development of excitonic devices.
Exploring Electro‐Thermal Interconversion in Oxide Superlattices Across Polarization Behavior Transition
Authors: Liu Junfu , Liu Yiqian , Lan Shun , Yang Bingbing , Dou Lvye , Yang Letao , Kong Xi , Nan Ce‐Wen , Lin Yuan‐Hua 
Published: April 2023

AbstractDue to the great demand for global energy consumption, electro‐thermal energy interconversion has drawn great attention. Ferroelectrics as promising candidates realize energy conversion through pyroelectric and electrocaloric effects, but their efficiency is not sufficiently high. Herein, using phase‐field simulations, it is demonstrated that superlattices with polar topologies tend to have various polarization behaviors, and the antiferroelectric‐ to paraelectric‐like phase transition induces a large polarization change and thus a high pyroelectric response. In KNbO3/KTaO3 superlattices, the pyroelectric energy conversion has a scaled efficiency of 50% and the equivalent ZT of 7.2, and the electrocaloric cooling temperature reaches 40 K. The operation temperature can be tuned by changing the thickness of the superlattice. The results reveal that oxide superlattices are competitive in energy harvesting and conversion, thus creating new application prospects for polar topologies.
Bone Loss in Inflammatory Rheumatic Musculoskeletal Disease Patients Treated With Low‐Dose Glucocorticoids and Prevention by Anti‐Osteoporosis Medications
Authors: Adami Giovanni , Fassio Angelo , Rossini Maurizio , Benini Camilla , Pistillo Francesca , Viapiana Ombretta , Bertelle Davide , Gatti Davide 
Published: April 2023

ObjectiveThe negative effects of glucocorticoids on bone depend on dose and treatment duration. However, it is unclear whether a safe dose exists, especially for patients with inflammatory rheumatic musculoskeletal diseases (iRMDs). We undertook this study to determine the effects of glucocorticoid doses on bone health in iRMD patients.MethodsWe conducted a longitudinal cohort study on women with iRMD. Bone mineral density (BMD) and fractures were assessed prospectively and compared to a matched cohort without iRMD. Kaplan‐Meier curves with log rank test were made for iRMD patients (stratified for glucocorticoid use and dose) and the matched cohort. Multivariable Cox regression survival models were also employed to analyze the effect of glucocorticoids on fracture.ResultsA total of 884 women with iRMD and 1,766 controls (matched for age, T score, and 10‐year fracture risk) were included in the study and followed up for up to 6 years. BMD decreased significantly in all patients receiving glucocorticoids who were not receiving anti‐osteoporosis treatment (–4.26% for ≥5 mg/day of prednisone equivalent, P = 0.0011; –4.23% for 2.5–5 mg/day, P = 0.0422; –2.66% for 0–2.5 mg/day, P = 0.0006). Anti‐osteoporosis treatment (largely bisphosphonates) prevented bone loss only in patients receiving <5 mg/day of prednisone equivalent. Fracture incidence was higher in patients with iRMD compared to controls, but only glucocorticoid doses ≥5 mg/day were associated with significantly higher risk of fracture.ConclusionGlucocorticoid doses as low as 2.5 mg/day were associated with BMD loss in iRMD patients, but this effect was preventable. BMD loss in patients receiving ≥5 mg/day was not totally prevented by anti‐osteoporosis medications currently used in clinical practice, resulting in higher risk of fracture.image
Arylidene Meldrum's Acid: A Versatile Structural Motif for the Design of Enzyme‐Responsive “Covalent‐Assembly” Fluorescent Probes with Tailor‐Made Properties**
Authors: Renault Kévin , Capello Yoan , Yao Shun , Halila Sami , Romieu Anthony 
Published: April 2023

AbstractLatent cyclic carbon‐centered nucleophiles (latent C‐nucleophiles) are recently proving their value in the field of reaction‐based fluorescent probes, far beyond their primary utility in organic synthesis. They are typically used to introduce a Michael acceptor moiety acting as a recognition/reaction site for analyte to be detected or as a kinetic promoter of fluorogenic cascade reactions triggered by a reactive species. C‐nucleophiles bearing a further reactive handle offer an additional opportunity for tuning the physicochemical/targeting properties or providing drug‐releasing capabilities to these probes, through the covalent attachment of ad hoc chemical moiety. In order to implement such strategy to fluorogenic/chromogenic enzyme substrates based on the “covalent‐assembly” principle, we have explored the potential of some functionalized derivatives of barbituric acid, piperidine‐2,4‐dione and Meldrum's acid. Our investigations based on the rational design and analytical validations of enzyme‐responsive caged precursors of fluorescent pyronin dyes and 7‐(diethylamino)coumarin‐3‐carboxylic acid, led to identify a versatile candidate suitable for this late‐stage structural optimization approach. This Meldrum's acid derivative enables to either enhance water solubility or achieve the reversible conjugation of a targeting ligand, while promoting in situ formation of fluorophore upon enzymatic activation. This study opens the way to novel multifunctional fluorescence imaging probes and optically modulated small conjugate‐based theranostics.
The new solution bounds of the discrete algebraic Riccati equation and their applications in redundant control inputs systems
Authors: Wang Li , Zhou Lei , Zhang Lu 
Published: April 2023

AbstractRedundant control inputs play an important part in engineering and are often used in control problems, dynamic control allocation, quadratic performance optimal control, and many uncertain systems. In this paper, by the equivalent form of the discrete algebraic Riccati equation (DARE), we propose new upper and lower bounds of the solution for the equivalent DARE. Compared with some existing work on this topic, the new bounds are more tighter. Next, when increasing the columns of the input matrix, we give the applications of these new upper and lower solution bounds to obtain a sufficient condition for strictly decreasing feedback controller gain. Finally, corresponding numerical examples illustrate the effectiveness of our results.
H∞ filtering for continuous fractional‐order 2D Roesser model: The 0<α≤1 case
Authors: Zhang Jia‐Rui , Lu Jun‐Guo 
Published: April 2023

AbstractThis paper investigates the
filtering for the continuous fractional‐order (FO) two‐dimensional (2D) Roesser model with the FO between 0 and 1. Firstly, a sufficient condition to ensure the stability and bounded realness in the sense of
‐norm for the continuous FO 2D Roesser model is given in the form of linear matrix inequalities (LMIs). Secondly, based on the bounded real lemmas proposed above, the
filtering problem for continuous FO 2D Roesser model is addressed through some congruent transformation and matrix transformation. The results are given in LMI form, and the parameters of the continuous FO 2D filters can be achieved from the LMIs easily. In the end, the effectiveness of the proposed results is verified by two numerical examples.
Student voice: Which supportive parental behaviours first‐generation immigrant students in Australia find beneficial
Authors: Malaeb Fatin T. , Ware Vicki‐Ann 
Published: April 2023

AbstractThere is considerable evidence that parents/guardians play an important role in their children's education. The supportive behaviours of parents have important implications for children's learning. However, most research in this area has focused primarily on the perspectives of school leaders, teachers and parents. One area that thus remains relatively under‐studied is student perspectives on what constitutes beneficial parental supports. This research explores two case studies: one with primary school students, the other with secondary students. Both studies interviewed students from former‐refugee and non‐English speaking backgrounds who had recently settled with their families in Australia. The students were asked to reflect on supportive behaviours of their parents/guardians relating to their education. Findings suggest that despite many barriers, parents demonstrated high levels of support for their children's education. By foregrounding student voice, this study identifies several types of parental behaviours that students find most helpful for effective learning. These include: affirmation, role‐modelling, backup supports, conversations and discussions, encouragement and advice, and decision‐making and problem‐solving. Students’ responses suggest that slightly different sets of behaviours may be required at primary and secondary levels. This study highlights the types of supportive parental behaviours which schools could encourage, to help parents maximise the impacts of their supports for students, so these students are enabled to achieve effective learning and—more broadly—educational and career aspirations.
The in vitro anti‐cancer synergy of neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid in glioblastoma
Authors: Ebrahimi Safieh , Mirzavi Farshad , Hashemy Seyed Isaac , Khaleghi Ghadiri Maryam , Stummer Walter , Gorji Ali 
Published: April 2023

AbstractGlioblastoma multiforme (GBM) is the most malignant type of cerebral neoplasm in adults with a poor prognosis. Currently, combination therapy with different anti‐cancer agents is at the forefront of GBM research. Hence, this study aims to evaluate the potential anti‐cancer synergy of a clinically approved neurokinin‐1 receptor antagonist, aprepitant, and 5‐aminolevulinic acid (5‐ALA), a prodrug that elicits fluorescent porphyrins in gliomas on U‐87 human GBM cells. We found that aprepitant and 5‐ALA effectively inhibited GBM cell viability. The combinatorial treatment of these drugs exerted potent synergistic growth inhibitory effects on GBM cells. Moreover, aprepitant and 5‐ALA induced apoptosis and altered the levels of apoptotic genes (up‐regulation of Bax and P53 along with downregulation of Bcl‐2). Furthermore, aprepitant and 5‐ALA increased the accumulation of protoporphyrin IX, a highly pro‐apoptotic and fluorescent photosensitizer. Aprepitant and 5‐ALA significantly inhibited GBM cell migration and reduced matrix metalloproteinases (MMP‐2 and MMP‐9) activities. Importantly, all these effects were more prominent following aprepitant–5‐ALA combination treatment than either drug alone. Collectively, the combination of aprepitant and 5‐ALA leads to considerable synergistic anti‐proliferative, pro‐apoptotic, and anti‐migratory effects on GBM cells and provides a firm basis for further evaluation of this combination as a novel therapeutic approach for GBM.
Virtual reality‐facilitated engineering education: A case study on sustainable systems knowledge
Authors: Han Bing , Weeks Daniel J. , Leite Fernanda 
Published: April 2023

AbstractSustainability research findings are imperative to reach a wide audience but are often hard to interpret for the general public because of their complex and interdisciplinary nature. Virtual reality (VR) is an emerging tool in education and research dissemination that can make information more accessible and engaging. This case study leveraged VR, gamification theory, and art design to develop an immersive experience that educates the general public with environmental engineering and sustainability knowledge. Through a series of informative and interactive games, this experience presented scientific findings while providing realism and entertainment throughout. This paper presents step‐by‐step guidelines for transferring engineering knowledge into a pedagogical VR experience, including human–computer interactions, storyboard development, data visualization, and gamification theory implementation. Participants provided positive feedback on the learning experience and stated that the experience sparked a curiosity to learn more about sustainability concepts. Improving opportunities for future development proposed during beta‐testing were also documented to guide future development. This case study contributes to the body of knowledge by validating the feasibility and effectiveness of incorporating VR and gamification theory in engineering education. Practically, the proposed development procedure can be implemented in various engineering education contents and scenarios.
Anti‐Inflammatory Effects of New Naphthyridine from Sponge Aaptos suberitoides in LPS‐Stimulated RAW 264.7 Macrophages via Regulation of MAPK and Nrf2 Signaling Pathways
Authors: Liu Mengshan , Zhang Zhen , He Qianqian , Qi Shizhou , Sun Kunlai , Miao Shuang , Wu Yan , Gong Kaikai 
Published: April 2023

AbstractTwo new naphthyridine compounds, 4‐methoxycarbonyl‐5‐oxo‐1,6‐naphthyridine (1) and 5‐methoxycarbonyl‐4‐oxo‐1,6‐naphthyridine (2) were obtained from the MeOH extracts of sponge Aaptos suberitoides. Their structures were determined by spectroscopic methods, including HR‐ESI‐MS, 1D‐NMR (1H‐NMR, 13C‐NMR), 2D‐NMR (COSY, HSQC, HMBC). The structure of compound 1 was further confirmed via single crystal X‐ray diffraction analysis. Compound 1 was found to reduce NO production in LPS‐induced RAW 264.7 macrophages with IC50 value of 0.15 mM. In addition, it decreased the mRNA expression levels of pro‐inflammatory mediators, such as the tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), interleukin‐1β (IL‐1β), inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX2) in LPS‐induced macrophages. It also decreased the protein expression of iNOS and COX‐2 in LPS‐induced macrophages. Mechanistic studies further revealed that compound 1 inhibited the mitogen‐activated protein kinase (MAPK), and activated the nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 (Nrf2/HO‐1) signaling pathways in LPS‐induced RAW 264.7 macrophages.
SNAP‐Tag‐Targeted MRI‐Fluorescent Multimodal Probes
Authors: Thankarajan Ebaston , Oz Shimrit , Saady Abed , Kulbitski Kseniya , Kompanets Mykhail O. , Eisen Moris S. , Berlin Shai 
Published: April 2023

AbstractMagnetic resonance imaging (MRI) is a powerful imaging modality, widely employed in research and clinical settings. However, MRI images suffer from low signals and a lack of target specificity. We aimed to develop a multimodal imaging probe to detect targeted cells by MRI and fluorescence microscopy. We synthesized a trifunctional imaging probe consisting of a SNAP‐tag substrate for irreversible and specific labelling of cells, cyanine dyes for bright fluorescence, and a chelated GdIII molecule for enhancing MRI contrast. Our probes exhibit specific and efficient labelling of genetically defined cells (expressing SNAP‐tag at their membrane), bright fluorescence and MRI signal. Our synthetic approach provides a versatile platform for the production of multimodal imaging probes, particularly for light microscopy and MRI.
Role of comprehensive cytogenomic investigation in successful reproductive outcome of parental small neocentromeric supernumerary ring chromosome: A case report
Authors: Wang Yiming , Lazier Joanna , Myles‐Reid Diane , Noor Abdul , Chitayat David , Greenfeld Elena 
Published: April 2023

AbstractSmall supernumerary marker chromosomes (sSMC) can form small supernumerary ring chromosomes (sSRC). Loss of parentally inherited sSRC containing vital gene content may cause an “unbalanced” karyotype and fetal microdeletion syndromes. Rarely, sSRC with neocentromere can be inherited, leading to a “balanced” karyotype, which can be diagnosed with preimplantation genetic testing.
Alveolar ridge augmentation with 3D‐printed synthetic bone blocks: A clinical case series
Authors: Perez Alexandre , Lazzarotto Benjamin , Marger Laurine , Durual Stéphane 
Published: April 2023

AbstractThis report documents the clinical and histological outcome of 3D‐printed calcium phosphate blocks placed in two‐stage procedures to successfully rehabilitate atrophic alveolar ridges. This approach yielded a functionally favorable result. Histological evaluations were performed after healing periods of 6 months and showed ongoing bone regeneration and sprouting capillaries.