bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of Hands Ultrasonography in the Differential Diagnosis Between Psoriatic Arthritis and Rheumatoid Arthritis
Authors: Abdelghani Kawther Ben , Boussaa Hiba , Miladi Saoussen , Zakraoui Leith , Fazaa Alia , Laatar Ahmed 
Published: March 2023

ObjectivesPsoriatic arthritis (PsA) can mimic rheumatoid arthritis (RA) at an early stage, especially when psoriasis is lacking. In the absence of specific radiological and immunological markers, the differential diagnosis between these two diseases can be challenging. We aimed to determine whether hands ultrasonography (US) may be useful in the differential diagnosis between PsA and RA.MethodsWe conducted a cross‐sectional study including patients with PsA and RA. All wrists and small joints of the hands were examined using gray‐scale and Power Doppler US. The evaluated US lesions were: synovitis, tenosynovitis of extensor carpi ulnaris, extensor communis and flexor tendons, enthesitis of extensor tendons at distal interphalangeal joints, peritendon inflammation of extensor tendons, and soft tissue edema.ResultsSix hundred joints in 20 PsA patients and 900 joints in 30 RA patients were assessed. Extensor enthesitis was significantly more observed in PsA compared with RA (39.4 vs 26.3%, P = .006) with a significant higher frequency of enthesophytes and calcifications (P = .022 and P = .002, respectively). Peritendon inflammation of extensor digitorum tendons was observed in 13% of metacarpophalangeal joints in PsA patients versus 3% in RA patients with a significant difference (P < .001). Soft tissue edema was exclusively observed in PsA (1.5 vs 0%, P = .033). Power Doppler synovitis was significantly more frequent in RA (9.2 vs 5%, P = .002). Extensor carpi ulnaris tenosynovitis was significantly more frequent in RA (18.3 vs 2.5%, P = .017).ConclusionExtrasynovial US findings may be helpful to distinguish PsA from RA especially in patients with immunonegative polyarthritis and no evidence of psoriasis.
Prognosis of Acute Low‐Tone Hearing Loss Without Vertigo: A Scoping Review
Authors: Huang Ryan J. , Del Risco Amanda , Riska Kristal M. , Cooper Matthew W. , Clark Nicholas W. , Kaplan Samantha J. , Kaylie David , Francis Howard W. 
Published: March 2023

ObjectiveDespite its relatively high prevalence, our understanding of the natural clinical course of acute low‐tone hearing loss (ALHL) without vertigo remains incomplete. The purpose of this study is to summarize the findings of studies that evaluated recovery from hearing loss (HL), recurrence and/or fluctuation of HL, and progression to Meniere's Disease (MD) of patients presenting with ALHL without vertigo.MethodsA scoping review of the English literature was performed. On May 14, 2020 and July 6, 2022, MEDLINE, Embase, and Scopus were searched to identify articles related to the prognosis of ALHL. To be included, articles had to present outcomes that were clearly distinguishable for patients with ALHL without vertigo. Two reviewers evaluated articles for inclusion and extracted data. Disagreements were adjudicated by a third reviewer.ResultsForty‐one studies were included. There was extensive heterogeneity between studies in regard to defining ALHL, treatment methods, and time of follow‐up. Most of the cohorts (39 out of 40) reported partial or complete recovery of hearing in the majority (>50%) of patients, although reports of recurrence were relatively common. Progression to MD was infrequently reported. Shorter time from onset of symptoms to treatment predicted better hearing outcomes in 6 of 8 studies.ConclusionThe literature suggests that although the majority of patients with ALHL experience hearing improvement, recurrence and/or fluctuation are common, and progression to MD occurs in a minority of patients. Additional trials utilizing standardized inclusion and outcome criteria are needed to determine the ideal treatment for ALHL.Level of EvidenceNA Laryngoscope, 133:2457–2469, 2023
Ferredoxin 1, the key regulator of cuproptosis, was associated with prognosis and immune cell infiltration in clear cell renal cell carcinoma
Authors: Xia Dian , Liu Kun , Jiao Wen , Peng Longfei , Liu Qi , Liu Chang , Bi Liangkuan 
Published: March 2023

AbstractAccording to a number of studies, the occurrence and progression clear cell renal cell carcinoma (ccRCC), among the most prevalent cancerous tumors of the urinary bladder, may be inextricable from metabolism and immunology. The recent discovery of cuproptosis revealed a novel cell death mechanism based on mitochondrial respiration and the tricarboxylic acid cycle, and cuproptosis is strongly linked to the metabolic process. The cuproptosis process is different from the previously revealed cell death processes such as pyroptosis, apoptosis and ferroptosis, which is expected to provide a new perspective in the study of tumor mechanism. Here we aim to explore the important role of key regulators of cuproptosis in renal cancer using a combination of bioinformatics and experimental validation. We found that Ferredoxin 1 (FDX1) was related to the infiltration of various immune cells in the tumor microenvironment and the response to immunotherapy in ccRCC. At the same time, the experiment confirmed that FDX1 was significantly lower in ccRCC, which was consistent with the previous analysis results. In conclusions, FDX1 was expected to be an important marker of immune infiltration, immunotherapy, and tumor prognosis in ccRCC.
Dual‐role nurse interpreter perceptions of language barriers and Spanish‐speaking patients: A qualitative study
Authors: Villanueva Lizette 
Published: March 2023

AbstractAimAs the United States population is ever changing and is growing in diverse population patterns, the health care system is called to initiate responsive health care practices that are based on the public's changing and diverse cultural patterns. This study sought to explore the perceptions of certified medical interpreter dual‐role nurses and their experiences with Spanish‐speaking patients from admission to discharge in hospital stays.DesignA qualitative descriptive case study was applied in this study.MethodsData was collected from nurses working at a United States Southwest Borderland hospital using purposive sampling and semi‐structured in‐depth interviews. A total of four dual‐role nurses participated, and thematic narrative analysis was applied.ResultsFour major themes emerged. The main themes were “being a dual‐role nurse interpreter,” “patient experience,” “culture and competence, “and “nursing and caring,” With each major theme multiple sub themes emerged. Two sub themes emerged with “being a dual‐role nurse interpreter,” and two sub themes emerged with “patient experiences.” The major themes that emerged from the interviews indicated that the language barrier greatly affects Spanish‐speaking patients in their hospital stay. Participants reported having at least one encounter with a Spanish‐speaking patient that was not afforded interpretation services or had interpretation from someone other than a qualified interpreter. Patients experienced confusion, apprehension and anger associated with not being able to communicate their needs to the healthcare system.ConclusionsAccording to the experiences of the certified dual‐role nurse interpreters, having a language barrier makes a tremendous impact on the care of Spanish‐speaking patients. Nurse participants describe how patients and their family members experience dissatisfaction, anger and confusion when there is a language barrier and most importantly how language barriers have detrimental effects on patients with wrong medication prescriptions and wrong diagnosis.Clinical relevanceWhen hospital administration recognize and support nurses as certified medical interpreters as a key component for patient care when assisting persons with limited English proficiency, patients are empowered to become active members of their healthcare regimen. The role of dual‐role nurses enables brokering between the healthcare system and serves as a tool to bridge health disparities based on linguistic inequities existing in healthcare. Recruitment and retention of certified medical interpreter trained Spanish‐speaking nurses deter errors in healthcare and makes a positive impact on the healthcare regimen of Spanish‐speaking patients enabling patient empowerment through education and advocacy.
Evaluation of computer‐based training and high‐fidelity simulation to improve early recognition of sepsis on the adult general ward
Authors: Marsack William J. , De Gagne Jennie C. , Reid Joseph , Pakieser‐Reed Katherine , Francisco Mary Ann , Kang Hee Sun 
Published: March 2023

AbstractThis quality improvement project involved developing, implementing and evaluating an educational intervention using computer‐based training (CBT) and high‐fidelity simulation (HFS) to increase knowledge, confidence and compliance of nurses identifying sepsis. A one‐group pretest‐posttest design was used. Participants were nurses on a general ward of an academic medical centre. Study variables were measured over three timepoints: 2 weeks before, immediately after and 90 days after implementation. Data were collected from January 30, 2018, to June 22, 2018. SQUIRE 2.0 checklist for quality improvement reporting used. Improvements in knowledge of sepsis (F(2,83) = 18.14, p < 0.001, ηp2 = 0.30) and confidence in early recognition of sepsis (F(2,83) = 13.67, p < 0.001, ηp2 = 0.25) were found. Additionally, compliance with sepsis screening improved between the preimplementation and postimplementation period (χ2 = 13.633, df = 1, p < 0.001). Overall, the nurses evaluated their experience with the CBT and HFS as strongly positive. When designing and implementing an educational intervention on sepsis, a process for follow‐up which provides reinforcement should be considered to retain nurses' knowledge.
Relationships among disease knowledge, social support, anxiety and self‐efficacy in patients after total knee arthroplasty: A chain mediating effect
Authors: Li Na , Yao Xue , Ji Hong 
Published: March 2023

AbstractAimTo explore relationships among disease knowledge, social support, anxiety and self‐efficacy in patients after total knee arthroplasty (TKA) through a chain mediating model.DesignA cross‐sectional study.MethodsA total of 282 post‐TKA patients from three tertiary hospitals in Jinan, Shandong Province are conveniently chosen as the subjects of this study. We use established scales to assess relevant variables and apply the PROCESS 3.5 software of SPSS to construct a chain mediating effect.ResultsThe results of this study found that disease knowledge can directly affect patients' self‐efficacy (β = 0.466, t = 5.227, p < 0.001). Social support and anxiety play a significant mediating role between disease knowledge and self‐efficacy, with an overall mediating effect value of 0.257. After including social support and anxiety, the direct effect value of disease knowledge on self‐efficacy is 0.210.ConclusionDisease knowledge in TKA patients can significantly and positively predict their post‐operative self‐efficacy. Between disease knowledge and self‐efficacy, there is not only an independent mediating effect of social support and anxiety but also a chain mediating effect.Patient or Public ContributionThe patients were actively involved in the data collection for this study.
New results on finite‐time guaranteed cost control of uncertain polytopic fractional‐order systems with time‐varying delays
Authors: Thanh Nguyen Truong , Thuan Mai Viet , Tuan Tran Ngoc 
Published: March 2023

AbstractThis article deals with the problem of finite time guaranteed cost control for uncertain polytopic fractional‐order systems with time‐varying delays. A linear quadratic cost function is considered as a performance measure for the closed‐loop system. By using Laplace transform and linear matrix inequalities (LMIs), a guaranteed cost controller design is presented and sufficient conditions for the existence of a finite time guaranteed cost state‐feedback control for the system are given in terms of LMIs. Two numerical examples are given to illustrate the effectiveness of the obtained result.
Soft dielectric actuator produced by multi‐material fused filament fabrication 3D printing
Authors: Raguž Ivan , Berer Michael , Fleisch Mathias , Holzer Clemens , Brancart Joost , Vanderborght Bram , Schlögl Sandra 
Published: March 2023

AbstractDielectric elastomer actuators rely on Coulomb forces for their actuation. They are promising candidates when it comes to the manufacture of electrically driven soft and lightweight robotic devices, which can undergo large movement. However, their commercial availability and hence their technological relevance are still rather limited due to several reasons: in‐depth material knowhow in terms of electrical and mechanical behavior required; materials have to be available in thin sheets; complicated and error prone fabrication; limited design freedom. In order to change this, this paper presents a soft dielectric actuator fully produced by fused filament fabrication. Additive manufacturing with conventional fused filament fabrication machines offers the potential for the production of personalized dielectric actuators which are easily accessible and comparably cheap. The only requirement is a fused filament fabrication printer with multi‐material capability. Focusing on a mass customization of the 3D printed actuators, exclusively commercially available devices and filaments without any modifications are used. In particular, the 3D printed prototypes are characterized in terms of the maximum displacement depending on the electrode printing direction. As a showcase example, a soft dielectric gripper made of two 3D printed actuators is developed. Comparable with other dielectric elastomer actuators, a maximum displacement of 42% is reached.
Efficacy of mirror therapy on lower limb motor recovery, balance and gait in subacute and chronic stroke: A systematic review
Authors: Kundi Maryam Khan , Spence Nicola J. 
Published: March 2023

AbstractObjectiveMirror therapy (MT) has been proposed to be an effective therapeutic regimen for lower limb stroke rehabilitation. This review is the first to evaluate the efficacy of MT in subacute and chronic stroke for lower‐limb motor functions, balance and gait focusing on particular stage of stroke with specific outcome measures.MethodsAccording to PRISMA guidelines, all relevant sources were searched from 2005 to 2020 using “PIOD” framework. Search methods included electronic database, hand and citation searching. Screening and quality assessment was performed by two individual reviewers. Data was extracted and synthesised from 10 studies. Thematic analysis was considered, random‐effect models were used and pooled analysis was performed using forest plots.ResultsFor motor recovery, MT showed statistically significant effects compared to control group using Fugl‐Meyer Assessment and Brunnstorm stages as outcome measures (SMD 0.59; 95% CI 0.29 to 0.88; p < 0.0001; I2 = 0%). Statistical significant improvement was reported for balance in MT compared to control using Berg Balance Scale and Biodex in pooled analysis (SMD 0.47; 95% CI 0.04 to 0.90; p = 0.03; I2 = 0%). When compared with electric stimulation and action‐observation training MT showed no signifiant improvement for balance (SMD −0.21; 95% CI −0.91 to 0.50; p = 0.56; I2 = 39%). For gait, MT showed statistical and clinical significant improvement compared to control group (SMD 1.13; 95% CI 0.27–2.00; p = 0.01; I2 = 84%) and when compared to action‐observation training and electrical stimulation, presented statistical improvement using 10‐m walk test and Motion Capture system (SMD −0.65; 95% CI −1.15 to −0.15; p = 0.01; I2 = 0%).ConclusionThis review has shown that MT is effective in lower‐limb motor recovery, balance and gait in subacute and chronic stroke in patients 18 years or above with no severe cognitive disorder, MMSE score ≥24 and FAC level ≥2. MT could be used for 30 min/day, 5 days/week for 4 weeks, as stand‐alone for motor recovery and balance or as an adjunct with electric stimulation for gait for beneficial effects.
Remaining useful life prediction of rolling bearings based on Bayesian neural network and uncertainty quantification
Authors: Jiang Guang‐Jun , Yang Jin‐Sen , Cheng Tian‐Cai , Sun Hong‐Hua 
Published: March 2023

AbstractThis paper constructs a remaining useful life (RUL) prediction model combining a convolutional neural network and a long short‐term memory network (CNNLSTM) to support decision‐making, especially the safety of rotational equipment. It avoids the influence of personnel and realizes the complementary advantages of the network. With the assistance of Bayesian short‐term and long‐term memory neural networks, the remaining life prediction method is able to provide the confidence interval of the remaining life prediction of rolling bearings. The compression between the proposed method and existing state‐of‐the‐art methods validated the good performance of the proposed method. Overall, the proposed method contributes to life prediction and condition‐based maintenance of bearings and complex rotational systems.
Ultra‐low current electrospray ionization of chloroform solution for the analysis of perfluorinated sulfonic acids
Authors: Wang Taoqing , Li Huishan , Allen Nicholas , Ferraro Ian , Li Anyin 
Published: March 2023

RationaleFemtoamp and picoamp electrospray ionization (ESI) characteristics of a nonpolar solvent were explored. The direct ESI mass spectrometry analysis of chloroform extract solution enabled rapid analysis of perfluorinated sulfonic acid analytes in drinking water.MethodsNeat chloroform solvent and extracts were directly used in a typical wire‐in ESI setup using micrometer emitter tips. Ionization currents were measured with femtoamp sensitivity while ramping the spray voltage from 0 to −5000 V. Methanol was used as a comparison to illustrate the characteristics of electrospraying chloroform. The effects of spray voltage and inlet temperature were studied. A liquid–liquid extraction workflow was developed to analyze perfluorooctanoate sulfonate (PFOS) in drinking water using an ion‐trap mass spectrometer.ResultsThe ionization onset of chloroform solution was 41 ± 17 fA at 300 V. The ionization current gradually increased with voltage while remaining below 100 pA when using voltages up to −5000 V. The ion signal of PFOS was significantly enhanced to improve the limit of detection (LoD) to 25 ppt in chloroform. Coupled with a liquid–liquid extraction workflow, LoD of 0.38–5.1 ppt and a quantitation range of 5–400 ppt were achieved for perfluorinated sulfonic compounds in 1‐ml water samples.ConclusionsFemtoamp and picoamp modes expand the solvent compatibility range of ESI and can enable quantitative analysis in parts per trillion (ppt) concentrations.
External enablers in existing organizations: Emergence, novelty, and persistence of entrepreneurial initiatives
Authors: Cestino Castilla Joaquin , Naldi Lucia , Ots Mart 
Published: March 2023

AbstractResearch SummaryThere is growing consensus that exogenous environmental changes can affect entrepreneurship. The external enabler framework, which provides the structures and terminology to analyze these enabling effects, has typically focused on new venture creation. In an attempt to extend the external enabler framework to corporate entrepreneurship and innovation, our longitudinal multiple‐case study explores how environmental changes enable entrepreneurial initiatives in existing organizations. Our findings contribute to the external enabler framework, corporate entrepreneurship, and innovation literature by identifying new conceptual tools to understand the enabling effect of environmental change for the emergence, novelty, and persistence of entrepreneurial initiatives in existing organizations.Managerial SummaryWe studied how the Covid‐19 pandemic enabled the initiation and continuation of entrepreneurial activities. Our study of eight small US‐based news companies shows that some entrepreneurial initiatives emerged as these organizations redirected their course of action toward new initiatives enabled by the changes in the external environment. Notably, the entrepreneurial initiatives that were new‐to‐the‐industry originated from ideas that were already available in some form within the organization but were not in use until the pandemic gave them a second life. Furthermore, the continuation of these initiatives depended on the persistence of the changes in the environment and on the low maintenance requirements of these initiatives in terms of time, effort, and resources.
Sulfur Polymer as Emerging Advanced Materials: Synthesis and Applications
Authors: Cherumukkil Sandeep , Agrawal Santosh , Jasra Raksh Vir 
Published: March 2023

AbstractAbundant availability of inexpensive sulfur coupled with its reactivity triggered the interest of scientific community to explore the unique chemistry of sulfur for developing advanced materials. The reactivity of sulfur diradicals is used for making copolymers with cross‐linker monomer dienes through inverse vulcanization principle which is later upgraded by conducting reactions in presence of catalysts so as to achieve functionalized sulfur copolymers at lower reaction temperatures and lower time. Multi‐component reactions provide an opportunity for the direct utilization of sulfur at mild conditions. The diverse processing methodologies have further expanded the applicability of sulfur polymeric materials. The dynamicity of the S−S bonds has potential to create avenue for making self‐healing materials and usher the generation of more functionalized segmented block co‐polymers with superior properties. Interfacial condensation polymerization has successfully been implemented for the generation of sulfur nanoparticles in aqueous medium. The recent emergence of sulfur quantum dots through various approaches generated more advanced sulfur based materials in terms of expanding sulfur applications. This review provides an account on advanced materials synthesized using sulfur as raw material and their respective applications.
Kinetic Mechanism for Simulating the Temperature and Pressure Effect on the Explosive Decomposition of Acetylene by ReaxFF Molecular Dynamics
Authors: Zhang Minhua , Zhou Baofeng , Chen Yifei , Gong Hao 
Published: March 2023

AbstractIn the utilization of acetylene as the raw material in chemical engineering, understanding its pyrolysis mechanism is a vital issue in avoiding its explosion. The ReaxFF MD simulation was adopted to investigate the pyrolytic behavior of acetylene at various temperatures and pressures. The simulation results revealed that the pyrolysis mechanism of acetylene could be divided into three temperature ranges: (i) T<1200 K, where homogenous molecular polymerization of acetylene occurs, producing polymerization products primarily C4H4 and C6H6; (ii) 1200<T<1800 K, where the free radical path competes with the molecular path, and free radicals such as C2H3⋅ and C4H3⋅ participate in the polymerization reaction; (iii) T>1800 K, where the acetylene molecule is cracked, and H⋅ and C2H⋅ drive the formation of polyacetylene and hydrogen. Finally, a reaction network for the pyrolysis of acetylene to yield compounds below C10 is generated through the identification, quantification, and evaluation of the reaction trajectory. The kinetic model of acetylene pyrolysis has been dramatically improved and supplemented, which is in satisfactory agreement with experimental values.
Palladium‐Catalyzed Cyclopropanation of Aryl/Heteroaryl Fluoro‐sulfonates
Authors: Guan Chenfei , Qi Huijie , Han Linjun , Liu Miaoyu , Wang Jing , Zhang Guofu , Ding Chengrong 
Published: March 2023

AbstractThe cyclopropane group is widely present as an important motif in pharmaceuticals and natural products. Herein, we report a cyclopropanation strategy by inexpensive and readily available aryl/heteroaryl fluorosulfonates. The strategy displays wide functional group compatibility and furnishes the corresponding cyclopropane products in excellent yields. The power of this new platform is showcased through one‐pot and gram‐scale experiments. This is reinforced by its application in late‐stage functionalization.