bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features, Antiviral Treatment, and Patient Outcomes: A Systematic Review and Comparative Analysis of the Previous and the 2022 Mpox Outbreaks
Authors: Li Pengfei , Li Jiajing , Ayada Ibrahim , Avan Amine , Zheng Qinyue , Peppelenbosch Maikel P , de Vries Annemarie C , Pan Qiuwei 
Published: February 2023

Abstract

Background
This study aims to comparatively analyze clinical features, treatment, and patient outcomes between the previous and the 2022 mpox (monkeypox) outbreaks.

Methods
Five bibliographic databases were searched for studies reporting clinical features, management, and patient outcomes of mpox. Systematic review and meta-analysis were performed.

Results
In total, 73 studies were included in the systematic review, of which 33 studies were subjected to meta-analysis. Previous outbreaks substantially affected children, whereas the 2022 outbreak primarily affected male adults, of which 94.66% (95% confidence interval [CI], 88.03–98.95) were men who have sex with men. Furthermore, 72.47% (95% CI, 51.04–89.71) reported high-risk sexual activity and the overall human immunodeficiency virus (HIV) prevalence was 37.65% (95% CI, 30.09–45.50). Skin lesions remain the typical symptom; however, their anatomic distribution differed. Systemic manifestations were common, but rectal pain was unique to the 2022 outbreak. The estimated overall fatality during past outbreaks in Africa was 4.61% (95% CI, 2.39%–7.35%), whereas 6.34% (95% CI, 3.35%–10.10%) of patients from the 2022 outbreak required hospitalization. Antiviral treatment, in particular tecovirimat, has been prescribed for a subset of patients, but the efficacy remains inconclusive.

Conclusions
These findings are important for better understanding the disease and guiding adequate response to mpox outbreaks.
The relationship between minimum inhibitory concentration and 28 day mortality in patients with a Gram-negative bloodstream infection: an analysis of data from a cohort study (BSI-FOO)
Authors: Evans Rebecca N , Harris Jessica , Rogers Chris A , MacGowan Alasdair P 
Published: February 2023

Abstract

Objectives
To explore the association between MIC/EUCAST breakpoint ratio and 28 day mortality in patients with a Gram-negative bloodstream infection (BSI).

Methods
Using data from the Bloodstream Infection—Focus on Outcomes (BSI-FOO) observational study, we defined an average MIC/EUCAST breakpoint ratio that was updated daily to reflect changes in treatment in the first 7 days after blood culture. Cox regression analysis was performed to estimate the association between MIC/EUCAST breakpoint ratio and mortality, adjusting for organism and a risk score calculated using potential confounding variables. The primary outcome was 28 day all-cause mortality from the date of blood culture.

Results
Of the 1903 study participants, 514 met the eligibility criteria and were included in the analysis (n = 357 Escherichia coli, n = 6 Klebsiella and n = 151 Pseudomonas aeruginosa). The average age was 74.0 years (IQR 60.0–82.0). The mortality rate varied from 11.1% (in patients treated with an average MIC/EUCAST breakpoint ratio of 1) to 27.6% (in patients treated with antibiotics with an average MIC/EUCAST breakpoint ratio &gt;1). After adjusting for risk score and organism, MIC/EUCAST breakpoint ratio was not associated with 28 day mortality (P = 0.148).

Conclusions
In an adjusted model controlling for potential confounding variables, there was no evidence to suggest a relationship between MIC/EUCAST breakpoint ratio and 28 day mortality in patients with a Gram-negative BSI.
Design and development of a digital shared decision-making tool for stroke prevention in atrial fibrillation
Authors: Nunes Julio C , Baykaner Tina , Pundi Krishna , DeSutter Katie , True Hills Mellanie , Mahaffey Kenneth W , Sears Samuel F , Morin Daniel P , Lin Bryant , Wang Paul J , Stafford Randall S 
Published: February 2023

Abstract

Background
Shared decision-making (SDM) is an approach in which patients and clinicians act as partners in making medical decisions. Patients receive the information needed to decide and are encouraged to balance risks, benefits, and preferences. Informative materials are vital to SDM. Atrial fibrillation (AF) is the most common cardiac arrhythmia and responsible for 10% of ischemic strokes, however 1/3 of patients are not on appropriate anticoagulation. Decision sharing may facilitate treatment acceptance, improving outcomes.

Aims
To develop a framework of the components needed to create novel SDM tools and to provide practical examples through a case-study of stroke prevention in AF.

Methods
We analyze the design values of a web-based SDM tool created to better inform AF patients about anticoagulation. The tool was developed in partnership with patient advocates, multi-disciplinary investigators, and private design firms. It was refined through iterative, recursive testing in patients with AF. Its effectiveness is being evaluated in a multisite clinical trial led by Stanford University and sponsored by the American Heart Association.

Findings
The main components considered when creating the Stanford AFib tool included: design and software; content identification; information delivery; inclusive communication, user engagement; patient feedback; clinician experience; and anticipation of implementation and dissemination. We also highlight the ethical principles underlying SDM; matters of diversity and inclusion, linguistic variety, accessibility, and health literacy. The Stanford AFib Guide patient tool is available at: https://afibguide.com and the clinician tool at https://afibguide.com/clinician.

Conclusion
Attention to a range of vital development and design factors can facilitate tool adoption and information acquisition by diverse cultural, educational, and socioeconomic subpopulations. With thoughtful design, digital tools may decrease decision regret and improve treatment outcomes across many decision-making situations in healthcare.
Effect of light environment on prey consumption in two species of larval stomatopods, Gonodactylaceus falcatus (Forskål, 1775) and Gonodactylellus sp. (Stomatopoda: Gonodactylidae)
Authors: McDonald Marisa , Porter Megan 
Published: February 2023

Abstract
While adult stomatopod crustaceans are relatively well studied, understanding of larval stomatopod ecology is lacking, largely due to difficulties studying larvae in their natural habitat. This study investigated how light environment (i.e., spectral composition) and time of day affected prey consumption in two species of larval stomatopod, Gonodactylaceus falcatus (Forskål, 1775) and Gonodactylellus sp. Individual larvae were placed with 20 Artemia nauplii prey in feeding chambers treated to produce different light environments with respect to ultraviolet (UV) light: full spectrum light UV+, full spectrum UV–, and a dark control. Chambers were lowered to a depth of 3 m for 2 hours at three times of day (noon, twilight, and night) to test 1) if larval feeding rates changed at different times of day and 2) if UV vision was involved in prey capture. We found that light was important for successful feeding, with both species eating significantly more in lighted treatments than the dark controls during daytime experiments. Gonodactylellus sp. also had a significantly higher feeding rate at twilight in the UV+ treatment than in the dark control. Both species showed decreased consumption at night compared to daytime rates, and decreased consumption in all dark controls. This study is one of the first to examine how ecological conditions affect feeding behavior in larval stomatopods. Our results suggest that light is important for larval stomatopod feeding, with differences between species in daily feeding activity periods. There was also a difference in total consumption between the two species, with the slightly larger Gonodactylaceus falcatus consuming nearly double the prey items as Gonodactylellus sp. at peak feeding times. Follow up studies should incorporate a variety of prey types to test how feeding changes based on food source and density.
Inoculation of Tomato With Plant Growth Promoting Rhizobacteria Affects the Tomato—Potato Psyllid—Candidatus Liberibacter Solanacearum Interactions
Authors: de Leon Victoria , Orr Katharine , Stelinski Lukasz L , Mandadi Kranthi , Ibanez-Carrasco Freddy 
Published: February 2023

Abstract
The Rio Grande Valley (RGV) in southern Texas is well-suited for vegetable production due to its relatively mild/warm weather conditions in the fall and winter. Consequently, insects inflict year-round, persistent damage to crops in the RGV and regions with similar climate. Bactericera cockerelli (Šulc) (Hemiptera: Triozidae), commonly known as the potato psyllid, is a known vector of Candidatus Liberibacter solanacearum (CLso) (Hyphomicrobiales: Rhizobiaceae), a fastidious phloem-limited bacterium associated to vein-greening in tomatoes and Zebra Chip in potatoes. Vector control is the primary approach of integrated pest management (IPM) strategies that aim to prevent plant diseases in commercial agricultural systems. However, resistance-selective pressures that decrease the effectiveness of chemical control (insecticide) applications over time are of increasing concern. Therefore, we explore an ecological approach to devising alternative IPM methodologies to manage the psyllid-transmitted CLso pathogen to supplement existing chemical products and application schedules without increasing resistance. In this study, our objective was to examine the effects of plant-growth promoting rhizobacteria (PGPR) on host-vector-pathogen interactions. Soil-drench applications of PGPRs to Solanum lycopersicum (Solanales: Solanaceae) seedlings revealed structural and possible physiological changes to the plant host and indirect changes on psyllid behavior: host plants had increased length and biomass of roots and exhibited delayed colonization by CLso, while psyllids displayed changes in parental (F0) psyllid behavior (orientation and oviposition) in response to treated hosts and in the sex ratio of their progeny (F1). Based on our results, we suggest that PGPR may have practical use in commercial tomato production.
Parental Uncertainty Scale Factor Structure in Pediatric DSD With Ambiguous Genitalia
Authors: Basile Nathan L , Dattilo Taylor M , DeLone Alexandra M , Kraft Jacob D , Edwards Clayton S , Buchanan Cindy L , Cheng Earl Y , Poppas Dix P , Wisniewski Amy B , Mullins Larry L 
Published: February 2023

Abstract

Objective
Illness uncertainty is a salient experience for caregivers of children with disorders/differences of sex development (DSD) presenting with ambiguous genitalia; however, no validated measure of illness uncertainty exists for this unique population. Thus, the current study aimed to preliminarily identify the factor structure of the Parental Perception of Uncertainty Scale (PPUS) in caregivers of children with DSD presenting with ambiguous genitalia and examine the convergent validity of the PPUS.

Methods
Participants included 115 caregivers (Mage = 32.12 years, SD = 6.54; 57% mothers) of children (&lt;2-year-olds) diagnosed with DSD participating in a larger, longitudinal study. Caregivers completed the PPUS as well as self-report measures of anxious, depressive, and posttraumatic stress symptoms. An exploratory factor analysis was conducted.

Results
Exploratory factor analysis results indicated that a 23-item 1-factor solution was the most parsimonious and theoretically sound factor structure (α = 0.92). Convergent validity analyses demonstrated further support for the use of the 23-item 1-factor solution over the original PPUS factor structure.

Conclusion
These results demonstrate the preliminary clinical and research utility of the PPUS with caregivers of children with DSD presenting with ambiguous genitalia. The PPUS may benefit from further refinement through qualitative research and item adaptation to capture uncertainties unique to DSD presenting with ambiguous genitalia. In addition, future research should replicate the proposed factor structure using confirmatory factor analysis with a separate, larger sample of caregivers of children with DSD to confirm the factor structure.
Genome-wide-association study and transcriptome analysis reveal the genetic basis controlling the formation of leaf wax in Brassica napus
Authors: Long Zhengbiao , Tu Mengxin , Xu Ying , Pak Haksong , Zhu Yang , Dong Jie , Lu Yunhai , Jiang Lixi 
Published: February 2023

Abstract
Cuticular wax protects plants from various biotic and abiotic stresses. However, the genetic network of wax biosynthesis and the environmental factors influencing leaf wax production in rapeseed (Brassica napus) remains unclear. Here, we demonstrated the role of leaf wax in the resistance to Sclerotinia infection in rapeseed. We found that leaves grown under high light intensity had higher expression of genes involved in wax biosynthesis, and produced more wax on the leaf surface, compared with those grown under low light conditions. Genome-wide association study (GWAS) identified 89 single nucleotide polymorphisms significantly associated with leaf wax coverage. A cross-analysis between GWAS and differentially expressed genes (DEGs) in the leaf epidermis of the accessions with contrasting differences in wax content revealed 17 candidate genes that control this variation in rapeseed. Selective sweep analysis combined with DEG analysis unveiled 510 candidate genes with significant selective signatures. From the candidate genes, we selected BnaA02.LOX4, a putative lipoxygenase, and BnaCnn.CER1, BnaA02.CER3, BnaC02.CER3, and BnaA01.CER4 (ECERIFERUM1–4) that were putatively responsible for wax biosynthesis, to analyse the allelic forms and haplotypes corresponding to high or low leaf wax coverage. These data enrich our knowledge about wax formation, and provide a gene pool for breeding an ideal leaf wax content in rapeseed.
Sequestration of zearalenone using microorganisms blend in vitro
Authors: Nathan Vignesh B , Lu Hang , Horn Nathan L , Drolia Rishi , Bhunia Arun K 
Published: February 2023

Abstract
Zearalenone (ZEN) is an estrogenic mycotoxin produced by the Fusarium species and induces severe reproductive disorders in animals thus a major concern in the livestock industry. Probiotic bacteria treatments have been shown to inactivate mycotoxins, therefore, in this study, we investigated the effect of two commercial probiotic feed additives on the sequestration of ZEN. Commercial probiotic blends containing clay-based binder with Aspergillus niger, Bacillus licheniformis, Bacillus pumilus, and Bacillus subtilis at various proportions from BioMatrix International were incubated with ZEN in a time-dependent manner and then analyzed by Enzyme-Linked Immunosorbent Assay (ELISA) to quantify unbound ZEN. Sequestration of ZEN was further verified by using MCF-7 cell-based cytotoxicity and/or cell proliferation assays. ZEN, or probiotic mix, was nontoxic to MCF-7 cells. Probiotic blends decreased ZEN concentration by 45% (∼100 μg L−1) and prevented ZEN from inducing MCF-7 cell proliferation (20%–28% reduction). The probiotic feed supplements tested show a potential utility in ZEN neutralization.
Origins of the UV/X-ray relation in Arakelian 120
Authors: Mahmoud R D , Done C , Porquet D , Lobban A 
Published: February 2023

ABSTRACTWe explore the accretion geometry in Arakelian 120 using intensive UV and X-ray monitoring from Swift. The hard X-rays (1–10 keV) show large amplitude, fast (few-day) variability, so we expect reverberation from the disc to produce UV variability from the varying hard X-ray illumination. We model the spectral energy distribution (SED) including an outer standard disc (optical), an intermediate warm-Comptonization region (UV and soft X-ray), and a hot corona (hard X-rays). Unlike the lower Eddington fraction AGN (NGC 4151 and NGC 5548 at L/LEdd ∼ 0.02 and 0.03, respectively), the SED of Akn 120 (L ∼ 0.05LEdd) is dominated by the UV, restricting the impact of reverberating hard X-rays by energetics alone. Illumination from a hard X-ray corona with height ∼10 Rg produces minimal UV variability. Increasing the coronal scale height to ∼100 Rg improves the match to the observed amplitude of UV variability as the disc subtends a larger solid angle, but results in too much fast variability to match the UV data. The soft X-rays (connected to the UV in the warm-Comptonization model) are more variable than the hard, but again contain too much fast variability to match the observed smoother variability seen in the UV. Results on lower Eddington fraction AGN have emphasized the contribution from reverberation from larger scales (the broad-line region), but reverberation induces lags on similar time-scales to the smoothing, producing a larger delay than is compatible with the data. We conclude that the majority of the UV variability is therefore intrinsic, connected to mass-accretion rate fluctuations in the warm-Comptonization region.
Dynamical evolution of massive black hole pairs in the presence of spin-dependent radiative feedback
Authors: Bollati Francesco , Lupi Alessandro , Dotti Massimo , Haardt Francesco 
Published: February 2023

ABSTRACTThe putative ubiquity of massive black holes (MBHs) at the centre of galaxies, and the hierarchical progress of structure formation along the cosmic history, together necessarily imply the existence of a large population of cosmic MBH binaries. Such systems are understood to be the loudest sources of gravitational waves at MHz frequencies, the regime that will be probed by the next Laser Interferometer Space Antenna. It has been proposed that the rate at which MBHs pair and then bind to form binaries is critically dependent upon the feedback exerted by the MBHs on the surrounding gaseous environment. Using the publicly available code gizmo, we perform a suite of simulations aimed at studying the dynamics of an MBH pair embedded in a gaseous disc on ∼100-pc scale. By means of dedicated modules, we follow the dynamics of MBHs in the presence of different spin-dependent radiative feedback models, and compare the results to a benchmark case with no feedback at all. Our main finding is that feedback causes the secondary MBH to shrink its orbit at a reduced pace, when compared with models where feedback is absent. Moreover, such slower inspiral occurs on eccentric orbits, as feedback has the net effect of hampering the circularization process. Though idealized in many aspects, our study highlights and quantities the importance of including spin-dependent feedback recipes in hydrodynamic simulations of MBH pairs, and ultimately in assessing the cosmological coalescence rate of such systems in view of their detection through gravitational waves.
A numerical study of fourth- and fifth-order retrograde mean motion resonances in planetary systems
Authors: Signor Alan Cefali , Caritá Gabriel Antonio , Morais Maria Helena Moreira 
Published: February 2023

ABSTRACT
We present a numerical study on the stability of all fourth- and fifth-order retrograde mean motion resonances (1/3, 3/1, 1/4, 4/1, 2/3, and 3/2) in the 3-body problem composed of a solar mass star, a Jupiter mass planet, and an additional body with zero mass (elliptic restricted problem) or masses corresponding to either Neptune, Saturn, or Jupiter (planetary problem). The fixed point families exist in all cases and are identified through libration of all resonant angles simultaneously. In addition, configurations with libration of a single resonant angle were also observed. Our results for the elliptic restricted 3-body problem are in agreement with previous studies of retrograde periodic orbits, but we also observe new families not previously reported. Our results regarding stable resonant retrograde configurations in the planetary 3-body problem could be applicable to extra-Solar systems.
M dwarf stars in the b294 field from the VISTA Variables in the Vía Láctea (VVV)
Authors: Cruz Patricia , Cortés-Contreras Miriam , Solano Enrique , Rodrigo Carlos , Minniti Dante , Alonso-García Javier , Saito Roberto K 
Published: February 2023

ABSTRACT
M dwarf stars are the dominant stellar population in the Milky Way, and they are important for a wide variety of astrophysical topics. The Gaia mission has delivered a superb collection of data, nevertheless, ground-based photometric surveys are still needed to study faint objects. Therefore, the present work aims to identify and characterize M dwarf stars in the direction of the Galactic bulge using photometric data and with the help of Virtual Observatory tools. Using parallax measurements and proper motions from Gaia Data Release 3, in addition to different colour-cuts based on VISTA filters, we identify and characterize 7 925 M dwarf stars in the b294 field from the Vista Variables in the Vía Láctea (VVV) survey. We performed a spectral energy distribution fitting to obtain the effective temperature for all objects using photometric information available at Virtual Observatory archives. The objects in our sample have temperatures varying from 2800–3900 K. We also search for periodic signals in VVV light curves with up to 300 epochs, approximately. As a secondary outcome, we obtain periods for 82 M dwarfs by applying two methods: the Lomb–Scargle and Phase Dispersion Minimization methods, independently. These objects, with periods ranging from 0.14–34 d, are good candidates for future ground-based follow up. Our sample has increased significantly the number of known M dwarfs in the direction of the Galactic bulge and within 500 pc, showing the importance of ground-based photometric surveys in the near-infrared.
A study of nine compact triply eclipsing triples
Authors: Rappaport S A , Borkovits T , Gagliano R , Jacobs T L , Tokovinin A , Mitnyan T , Komžík R , Kostov V B , Powell B P , Torres G , Terentev I , Omohundro M , Pribulla T , Vanderburg A , Kristiansen M H , Latham D , Schwengeler H M , LaCourse D , Bíró I B , Csányi I , Czavalinga D R , Garai Z , Pál A , Rodriguez J E , Stevens D J 
Published: February 2023

ABSTRACTIn this work, we report the independent discovery and analysis of nine new compact triply eclipsing triple star systems found with the Transiting Exoplanet Survey Satellite (TESS) mission: TICs 47151245, 81525800, 99013269, 229785001, 276162169, 280883908, 294803663, 332521671, and 356324779. Each of these nine systems exhibits distinct third-body eclipses where the third (‘tertiary’) star occults the inner eclipsing binary (EB), or vice versa. We utilize a photodynamical analysis of the TESS photometry, archival photometric data, TESS eclipse timing variations of the EBs, available archival spectral energy distribution (SED) curves, and, in some cases, newly acquired radial velocity observations, to solve for the parameters of all three stars, as well as most of the orbital elements. From these analyses we find that the outer orbits of all nine systems are viewed nearly edge on (i.e. within ≲4°), and six of the systems are coplanar to within 5°; the others have mutual inclination angles of 20°, 41°, and possibly 179° (i.e. a retrograde outer orbit). The outer orbital periods range from 47.8 to 604 d, with eccentricities spanning 0.004–0.61. The masses of all 18 EB stars are in the range of 0.9–2.6 M⊙ and are mostly situated near the main sequence. By contrast, the masses and radii of the tertiary stars range from 1.4 to 2.8 M⊙ and 1.5 to 13 R⊙, respectively. We make use of the system parameters from these nine systems, plus those from a comparable number of compact triply eclipsing triples published previously, to gain some statistical insight into their properties.