bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and genetic risk factors and long-term outcomes of MRI vessel wall enhancement in moyamoya disease
Authors: Hao Fangbin , Han Cong , Lu Mingming , Wang Yue , Gao Gan , Wang Qiannan , Liu Shitong , Liu Simeng , Wang MinJie , Yang Rimiao , Zou Zhengxing , Yu Dan , Sun Caihong , Zhang Qian , Zhang Houdi , Guo Qing-Bao , Wang Xiaopeng , Shen XuXuan , Fu Heguan , Li JingJie , Ren Bin , Wang Hui , Zhang Hongtao , Tong Huaiyu , Liu Wanyang , Sun Zhenghui , Cai Jianming , Duan Lian 
Published: May 2023

AbstractBackgroundIntracranial vessel wall enhancement (VWE) on high-resolution magnetic resonance imaging (HRMRI) is associated with the progression and poor prognosis of moyamoya disease (MMD). However, the genetic background and risk factors for VWE in MMD have not been investigated. Therefore, this study assessed potential risk factors for VWE in MMD.MethodsWe evaluated MMD patients using HRMRI and traditional angiography examinations. The participants were divided into VWE group and non-VWE group based on the presence or absence of VWE on HRMRI. Logistic regression was performed to compare the risk factors for VWE in MMD. The incidence of cerebrovascular events of the different subgroups according to risk factors were compared using Kaplan – Meier survival and Cox regression.. STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines were followed for reporting our cohort study.ResultsWe included 283 MMD patients, 84 of whom had VWE on HRMRI. The VWE group had higher modified Rankin Scale scores at admission (P= 0.014) and a higher incidence of ischemia and hemorrhage (P=0.002) than did the non-VWE group. Multiple logistics regression shows risk factors for VWE included the ring finger protein 213 (RNF213) pR4810K variant (OR: 2.01 [95% confidence interval (CI), 1.08 - 3.76];P= 0.028), hyperhomocysteinemia (HHcy; OR: 5.08 [95% CI, 2.34 - 11.05],P< 0.001), and smoking history (OR, 3.49 [95% CI, 1.08-11.31],P= 0.037). During the follow-up of 63.9 ± 13.2 months (medium 65 months), 18 recurrent stroke events occurred. Cox regression showed that VWE andRNF213 pR4810Kvariant were risk factors for follow-up stroke.ConclusionTheRNF213 p.R4810Kvariant is strongly associated with VWE and poor prognosis in MMD. HHcy and smoking are independent risk factors for VWE; both are likely to induce the VWE phenomenon by affecting vascular endothelial function or causing vascular endothelial damage.
Associations of schizophrenia with arrhythmic disorders and electrocardiogram traits: an in-depth genetic exploration of population samples
Authors: Treur Jorien L , Thijssen Anaïs B , Smit Dirk JA , Tadros Rafik , Veeneman Rada R , Denys Damiaan , Vermeulen Jentien M , Barc Julien , Bergstedt Jacob , Pasman Joëlle A , Bezzina Connie R , Verweij Karin J H 
Published: May 2023

AbstractBackgroundAn important contributor to the decreased life expectancy of individuals with schizophrenia is sudden cardiac death. While arrhythmic disorders play an important role in this, the nature of the relation between schizophrenia and arrhythmia is not fully understood.MethodsWe leveraged summary-level data of large-scale genome-wide association studies of schizophrenia (53,386 cases 77,258 controls), arrhythmic disorders (atrial fibrillation, 55,114 cases 482,295 controls; Brugada syndrome, 2,820 cases 10,001 controls) and electrocardiogram traits (heart rate (variability), PR interval, QT interval, JT interval, and QRS duration, n=46,952-293,051). First, we examined shared genetic liability by assessing global and local genetic correlations and conducting functional annotation. Next, we explored bidirectional causal relations between schizophrenia and arrhythmic disorders and electrocardiogram traits using Mendelian randomization.OutcomesThere was no evidence for global genetic correlations, except between schizophrenia and Brugada (rg=0·14,p=4·0E-04). In contrast, strong positive and negative local genetic correlations between schizophrenia and all cardiac traits were found across the genome. In the strongest associated regions, genes related to immune system and viral response mechanisms were overrepresented. Mendelian randomization indicated a causal, increasing effect of liability to schizophrenia on Brugada syndrome (OR=1·15,p=0·009) and heart rate during activity (beta=0·25,p=0·015).InterpretationWhile there was little evidence for global genetic correlations, specific genomic regions and biological pathways important for both schizophrenia and arrhythmic disorders and electrocardiogram traits emerged. The putative causal effect of liability to schizophrenia on Brugada warrants increased cardiac monitoring and potentially early medical intervention in patients with schizophrenia.FundingEuropean Research Council Starting Grant.
A Multi-Epitope/CXCL11 Prime/Pull Coronavirus Mucosal Vaccine Boosts the Frequency and the Function of Lung-Resident CD4+and CD8+Memory T Cells and Protects Against COVID-19-like Symptoms and Death Caused by SARS-CoV-2 infection
Authors: Zayou Latifa , Prakash Swayam , Dhanushkodi Nisha Rajeswari , Quadiri Afshana , Ibraim Izabela Coimbra , Singer Mahmoud , Salem Amirah , Shaik Amin Mohammed , Suzer Berfin , Chilukuri Amruth , Tran Jennifer , Nguyen Pauline Chau , Sun Miyo , Hormi-Carver Kathy K. , Belmouden Ahmed , Vahed Hawa , Ulmer Jeffrey B. , BenMohamed Lbachir 
Published: May 2023

ABSTRACTThe pandemic of the coronavirus disease 2019 (COVID-19) has created the largest global health crisis in almost a century. Following exposure to SARS-CoV-2, the virus particles replicate in the lungs, induce a “cytokine storm” and potentially cause life-threatening inflammatory disease. Low frequencies of function SARS-CoV-2-specific CD4+and CD8+T cells in the lungs of COVID-19 patients were associated with severe cases of COVID-19. The apparent low level of T cell-attracting CXCL9, CXCL10, and CXCL11 chemokines in infected lungs may not be sufficient enough to assure the sequestration and/or homing of CD4+and CD8+T cells from the circulation into infected lungs. We hypothesize that a Coronavirus vaccine strategy that boosts the frequencies of functional SARS-CoV-2-specific CD4+and CD8+T cells in the lungs would lead to better protection against SARS-CoV-2 infection, COVID19-like symptoms, and death. In the present study, we designed and pre-clinically tested the safety, immunogenicity, and protective efficacy of a novel multi-epitope//CXCL11 prime/pull mucosal Coronavirus vaccine. This prime/pull vaccine strategy consists of intranasal delivery of a lung-tropic adeno-associated virus type 9 (AAV-9) vector that incorporates highly conserved human B, CD4+CD8+cell epitopes of SARS-CoV-2 (prime) and pulling the primed B and T cells into the lungs using the T cell attracting chemokine, CXCL-11 (pull). We demonstrated that immunization of HLA-DR*0101/HLA-A*0201/hACE2 triple transgenic mice with this multi-epitope//CXCL11 prime/pull Coronavirus mucosal vaccine: (i) Increased the frequencies of CD4+and CD8+TEM, TCM, and TRMcells in the lungs; and (ii) reduced COVID19-like symptoms, lowered virus replication, and prevented deaths following challenge with SARS-CoV-2. These findings discuss the importance of bolstering the number and function of lung-resident memory CD4+and CD8+T cells for better protection against SARS-CoV-2 infection, COVID-19-like symptoms, and death.
Acute pain drives different effects on local and global cortical excitability in motor and prefrontal areas: Insights into interregional and interpersonal differences in pain processing
Authors: De Martino Enrico , Casali Adenauer , Casarotto Silvia , Hassan Gabriel , Rosanova Mario , Graven-Nielsen Thomas , Ciampi de Andrade Daniel 
Published: May 2023

ABSTRACTPain-related depression of motor cortico-spinal excitability has been explored using transcranial magnetic stimulation (TMS)-based motor evoked potentials. Recently, TMS combined with concomitant high-density electroencephalography (TMS-EEG) enabled cortical excitability (CE) assessments in non-motor areas, offering novel insights into CE changes during pain states. Here, pain-related CE changes were explored in the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC). CE was recorded in 24 healthy participants before (Baseline), during painful heat (Acute Pain), and non-painful warm (Non-noxious warm) stimulation for eight minutes at the right forearm in a randomized sequence, followed by a pain-free stimulation measurement. Local CE was measured as peak-to-peak amplitude of the early latencies of the TMS-evoked potential (<120 ms) on each target. Furthermore, global-mean field power (GMFP) was used to measure global excitability. Relative to the Baseline, Acute Pain induced a decrease of −9.9±8.8% in the peak-to-peak amplitude in M1 and −10.2±7.4% in DFPFC, while no significant differences were found for Non-noxious warm (+0.6±8.0% in M1 and +3.4±7.2% in DLPFC; both P<0.05). A reduced GMFP of - 9.1±9.0% was only found in M1 during Acute Pain compared with Non-noxious warm (P=0.003). Participants with the largest reduction in local CE under Acute Pain showed a negative correlation between DLPFC and M1 local CE (r=-0.769; P=0.006). Acute experimental pain drove differential pain-related effects on local and global CE changes in motor and non-motor areas at a group level while also revealing different interindividual patterns of CE changes, which can be explored when designing personalized treatment plans.SUMMARYCortical motor and prefrontal areas present reduced excitability during acute pain, but they occur in different patterns across individuals and present distinct impacts on global connectivity.
Illegal slaughter of sheep for “smokies” production and for the Muslim sacrifice of Qurbani in the UK: animal welfare and food safety implications
Authors: Fuseini Awal 
Published: May 2023

Purpose It is the expectation of Halal consumers that the meat they buy in retail shops and restaurants are ethically and legally reared and slaughtered in approved premises to protect animal welfare and public health. While this may be the case in multinational and well-established supermarkets due to due diligence on the part of retailers, there is evidence to suggest that some independent retail shops and ethnic restaurants in the UK partake in selling meat from illegally slaughtered animals. It is a crime that involves many players, but usually masterminded by rural entrepreneurs, including rogue farmers who supply the animals for illegal slaughter and further processing into smokies, or as part of the Islamic festival of Qurbani, in makeshift abattoirs. The purpose of this paper is to highlight illegal slaughter of sheep for the Halal market and how these impacts on food integrity and animal welfare.Design/methodology/approachThis paper examines the legality of slaughter in accordance with UK animal welfare and food safety legislations. The documentary research approach is adopted to examine available information on the activities of organised criminal gangs in the production of smokies and their possible involvement in Qurbani fraud.FindingsThis paper demonstrates the involvement of some rogue farmers who are facilitating the smokies trade and illegal slaughter of sheep during the Qurbani sacrifice. It is worth noting that while these illegal activities occur in the Halal sector, the perpetrators are not always Muslims. The processing of illegally slaughtered sheep takes place in unhygienic conditions which is of food safety, public health concern and may violate the religious rules around slaughter.Originality/valueIllegal slaughter for the Muslim sacrifice of Qurbani is underreported, this paper aims to highlight the animal welfare and food safety aspects of this type of slaughter, in addition to those slaughtered for smokies production.
Unconventional luxury brand collaborations: a new form of luxury consumption among young adults in China
Authors: Diaz Ruiz Carlos , Cruz Angela Gracia B. 
Published: May 2023

PurposeThis study conceptualizes a form of luxury consumption in which luxury brands collaborate with unconventional non-luxury partners. These unconventional luxury brand collaborations are growing in popularity among Chinese luxury consumers of the post-1990s generation. Luxury brands are exploring new branding strategies due to the growing commercial importance of Chinese luxury consumers. Design/methodology/approachAn in-depth qualitative study informs this paper. Interviews with young adult luxury consumers self-identifying as Chinese reveal a growing interest for luxury brands that collaborate with odd partners in social media and online culture.FindingsUnconventional collaborations between luxury brands and non-luxury partners catalyze shifting meanings of luxury through the following juxtapositions: ephemeral instead of timeless, trendy rather than inaccessible, and playful in contrast with traditional. First, young Chinese consumers construct luxury meanings through ephemerality, like digital possessions, social media fame and fleeting experiences. Second, luxury meanings emerge in trendiness among social media influencers and online culture rather than in the seemingly inaccessible taste regimes of the upper class. Third, younger consumers appreciate fun, rebellious and over-the-top aesthetics in luxury brands.Originality/valueThe study contributes to the nascent field of unconventional luxury by conceptualizing how unusual, odd and unexpected collaborations constitute new forms of luxury consumption. The shifting meanings of luxury consumption that this study conceptualizes raise new opportunities and challenges for luxury brands. One of such is the release of limited collections with non-luxury partners seemingly at the opposite spectrum of design, image and values. Moreover, the study adds nuance to the understanding of luxury consumption among young Chinese consumers.
An improved measure of conforming tax avoidance
Authors: Lou Yang , Wang Yicheng , Wright Brian 
Published: May 2023

Purpose
This study aims to propose a new conforming tax measure based on the work of Badertscher et al. (2019).

Design/methodology/approach
This study divides total tax avoidance/management (TM) into nonconforming and conforming portions through a regression. The residual of the regression is treated as the conforming tax measure. In addition, the new conforming tax measure is validated via three approaches. Then, this study examines the moderating effect of nonconforming earnings management (EM) on the relationship between conforming TM and firm performance.

Findings
The empirical results show that the model has stronger explanatory power than the model proposed by Badertscher et al. (2019). Additionally, the validation results show that the mean value of the conforming tax measure is lower in quasi-private corporations (financially constrained companies) than in matched public corporations (nonfinancially constrained companies), and firms under high market capital pressure are less motivated to engage in conforming tax practices. Furthermore, nonconforming EM positively moderates the conforming tax–ROA association, implying that nonconforming EM can reduce financial reporting costs resulting from conforming tax practices.

Originality/value
This study contributes to conforming tax research in the following ways. First, this study proposes a new conforming tax measure by substituting the cash book tax difference (BTD) for the BTD in the model of Badertscher et al. (2019) (“BKRW”). Second, this study demonstrates theoretically why the cash BTD should outperform the BTD in computing the BKRW conforming tax measure and confirm this empirically. Third, this study presents a three-way conceptual schema that divides corporations into two groups along each of three tax-relevant dimensions. The group of firms that use both conforming and nonconforming tax strategies have different characteristics compared to the other group. This study also validates the conforming tax measure across the two-group dichotomies.
A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics
Authors: Agrawal Neetu , Dhakrey Parth , Pathak Shilpi 
Published: May 2023

AbstractDiabetes mellitus (DM) is a serious global health concern affecting over 500 million people. To put it simply, it is one of the most dangerous metabolic illnesses. Insulin resistance is the root cause of 90% of all instances of diabetes, all of which are classified as Type 2 DM. Untreated, it poses a hazard to civilization since it can lead to terrifying consequences and even death. Oral hypoglycemic medicines presently available act in a variety of ways, targeting various organs and pathways. The use of protein tyrosine phosphatase 1B (PTP1B) inhibitors, on the contrary, is a novel and effective method of controlling type 2 diabetes. PTP1B is a negative insulin signaling pathway regulator; hence, inhibiting PTP1B increases insulin sensitivity, glucose absorption, and energy expenditure. PTP1B inhibitors also restore leptin signaling and are considered a potential obesity target. In this review, we have compiled a summary of the most recent advances in synthetic PTP1B inhibitors from 2015 to 2022 which have scope to be developed as clinical antidiabetic drugs.
Sleep disorders in dermatology – a comprehensive review
Authors: Mann Caroline , Gorai Surajit , Staubach‐Renz Petra , Goldust Mohamad 
Published: May 2023

SummarySleep is a normal physiological process that accounts for approximately one third of a person's life. Disruption of the normal sleep cycle, which maintains physiological homeostasis, can lead to pathology. It is not known whether sleep disturbance causes skin disease or skin disease causes sleep impairment, but a bidirectional influence is suspected. We have compiled the data from published articles on “sleep disorders in dermatology” in PubMed Central from July 2010 to July 2022 (with the option “full text available”) and provide an overview of sleep disorders associated with dermatological conditions and certain drugs used in dermatology as well as sleep disturbances for which some drugs used can cause itch or dermatological issues. Atopic dermatitis, eczema and psoriasis have been shown to be exacerbated by sleep problems and vice versa. Sleep deprivation, night‐time pruritus and disrupted sleep cycles are often used to assess treatment response and quality of life in these conditions. Some medications used primarily for dermatological conditions have also been associated with alterations in the sleep‐wake cycle. Addressing patients sleep disorders should be an integral part of the management of dermatological conditions. More studies are needed to further investigate the influence of sleep and skin disorders.
Factors predicting oral and maxillofacial fractures after falling and factors predicting the duration of treatment
Authors: Machida Yoshisato , Tomioka Takahiro , Koshinuma Shinya , Nakamura Mami , Yamamoto Gaku , Hitosugi Masahito 
Published: May 2023

AbstractBackground/AimThe first objective of this study was to identify predictive factors for oral and maxillofacial fractures at the initial response to the patient. The second objective was to determine the factors influencing the incidence of treatment duration of more than 1 month using the information shown in the medical record.Materials and MethodsHospital records from 2011 to 2019 were reviewed to identify patients who had sustained oral and maxillofacial injuries by falling or falling from a height. Patterns and types of oral and maxillofacial injury, injury severity, and background of the injury were collected from the hospital records. The variables independently associated with a treatment duration of more than 1 month were determined by logistic regression analysis.ResultsIn total, 282 patients (150 men, 132 women; median age, 17.5 years) were selected for analysis. Maxillofacial fractures were observed in 20.9% of patients (59/282); among these, mandibular fractures were the most common (47/59). Logistic regression analysis showed that age (odds ratio [OR], 1.026), nighttime occurrence (OR, 2.192), and upper face injury (OR, 20.704) were independent predictive factors for having a maxillofacial fracture. Additionally, the number of injured teeth (OR, 1.515) and the use of intermaxillary fixation (OR, 16.091) were independent predictors of treatment duration of more than 1 month.ConclusionsThese results may be useful in the initial management of maxillofacial injuries in terms of better‐informing patients injured by falling their expected treatment duration and managing the psychological impacts of a long treatment duration.
Treatment in patients with acute myeloid leukemia/high‐risk myelodysplastic syndrome with hypomethylating agents: Day‐hospital management compared to home care setting
Authors: Trapè Giulio , De Angelis Gioia , Morucci Marco , Tarnani Michela , De Gregoris Cinzia , Di Veroli Ambra , Panichi Valentina , Topini Giuseppe , Bassi Loredana , Isidori Raffaella , Poscente Monica , Innocenti Vincenza , Cippitelli Elisa Emanueli , Talucci Roberta , Bertelli Silvia , Crocicchia Alessandra , Lippi Annalisa , Pezzuti Giulia , Fuschino Michela , Randi Raffaella , Mastini Cristina , Ciambella Silvia , Pessina Gloria , Montanaro Marco , Latagliata Roberto 
Published: May 2023

AbstractObjectivesAim of the study was to evaluate the role of a Domiciliary Hematologic Care Unit (DHCU) compared to standard DH setting in the active frontline treatment with hypomethylating agents (HMAs) +/− venetoclax of frail patients with acute myelogenous leukemia/high‐risk myelodysplastic syndromes (AML/HR‐MDS).MethodsAll patients with newly diagnosed AML/HR‐MDS unfit for intensive care and treated frontline with HMAs from January 2010 to April 2021 were retrospectively included.ResultsAmong 112 patients (62 AML/50 HR‐MDS), 69 (61.6%) were treated in a standard DH setting and 43 (38.4%) were followed by DHCU, allocated to DH or DHCU by responsible physician. Overall response rate was 29/69 (42.0%) in DH versus 19/43 (44.1%) in DHCU (p = .797). Median response duration was 8.7 months (95%CI 7.0–10.3) in DH versus 13.0 months (95%CI 8.3–17.6) in DHCU (p = .460). Infections were also equally reported. Median overall survival of patients treated in DH was 13.7 months (95%CI 9.9–17.4) compared to 13.0 months (95%CI 6.7–19.3) of patients managed by DHCU (p = .753).ConclusionsHome care management of HMA is feasible and effective, with results similar to standard DH setting: this approach is thus adequate to offer active therapies in frail patients with AML/HR‐MDS considered up to now ineligible.
Mental agency and rational subjectivity
Authors: Campbell Lucy , Greenberg Alexander 
Published: May 2023

AbstractPhilosophy is witnessing an “Agential Turn,” characterised by the thought that explaining certain distinctive features of human mentality requires conceiving of many mental phenomena as acts, and of subjects as their agents. We raise a challenge for three central explanatory appeals to mental agency––agentialism about doxastic responsibility, agentialism about doxastic self‐knowledge, and an agentialist explanation of the delusion of thought insertion: agentialists either commit themselves to implausibly strong claims about the kind of agency involved in the relevant phenomena, or make appeals to agency which seem explanatorily redundant. The agentialist literature does not contain a clear answer to this Agentialist Dilemma, and we put it forward here as a core challenge for the Agential Turn. But we also accept the fundamental motivation behind the Agential Turn, its critique and rejection of a purely passivist and spectatorial conception of the human mind. We close by urging the recognition of a broader category of rational subjectivity, a category which includes states which are neither active nor passive, but nevertheless form part of a subject's rational point of view on the world.