bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the health status evaluation method of rolling bearing based on EMD‐GA‐BP
Authors: Liu Yangshuo , Kang Jianshe , Bai Yunjie , Guo Chiming 
Published: April 2023

AbstractTo more accurately evaluate the health state of rolling bearings, this paper proposes a health status evaluation method based on empirical pattern decomposition, genetic algorithm and BP neural network. Firstly, the vibration signal is decomposed by empirical mode decomposition (EMD) and the time domain features of each intrinsic mode function (IMF) component are extracted, and the signal‐to‐noise ratio (Snr) of the signal is improved effectively. Then, the initial threshold and weight of BP neural network are optimized by genetic algorithm, which effectively improves the Snr of the signal. Finally, the extracted features are input into the optimized BP neural network to realize the identification of different states of the bearing. The effectiveness of the method has been effectively verified in the bearing data of Case Western Reserve University bearing dataset and it has higher accuracy and robustness than other common evaluation methods.
Lambert‐Eaton myasthenic syndrome with primary thymic marginal zone B‐cell lymphoma: A case report
Authors: Soma Toshihiko , Matsumoto Akira , Shoji Tsuyoshi , Katakura Hiromichi 
Published: April 2023

AbstractLambert‐Eaton myasthenic syndrome (LEMS) is an autoimmune paraneoplastic syndrome with proximal muscle weakness, that often complicates small cell lung cancer. It is known that neurological symptoms do not improve with malignancy treatment alone in many LEMS patients, therefore treatment is often difficult. Since Lambert‐Eaton myasthenic syndrome is a rare disease with a frequency of about 1/100 that of myasthenia gravis, there are only a few case reports on malignancy complications other than small cell lung cancer. We report a LEMS patient in his 40s who was found to have an anterior mediastinal mass. We performed surgical resection and confirmed the diagnosis of primary thymic marginal zone B‐cell lymphoma by pathological diagnosis using immunostaining. Thymectomy and malignant lymphoma treatment with rituximab had no effect on neurological symptoms. The neurological symptoms improved only after we provided comprehensive care with the haematology, neurology, and rehabilitation department.
Physiologic 18F‐FDG muscle uptake in severe COPD: Implications for accurate lung cancer staging
Authors: Yoshida Yuma , Ikeo Satoshi , Yasuda Naoaki , Sakai Yuki , Hayashi Yasuyuki , Sokai Akihiko , Iwata Toshiyuki , Nishimura Takashi 
Published: April 2023

Key messageRecognizing physiologic 18F‐fluorodeoxyglucose (FDG) uptake in severe COPD is crucial to avoid mistaking it for lung cancer metastasis. Correlating 18F‐FDG avid lesions with co‐registered computed tomography is essential for accurate lung cancer staging and preventing unnecessary interventions.
A DFT Study on the Conformation, Properties of the Excited States, and Excimer's Formation of Tetraphenylcyclotetrasiloxane
Authors: Ding Yunqiao , Xu Zhen , Mou Qiuhong , Wang Xingjian , Zhou Chuanjian , Diao Guangzhao 
Published: April 2023

AbstractThe present study performed a DFT study on the conformation dependence of the properties of excited states and the excimer's formation for the tetramethyl tetraphenyl cyclotetrasiloxane. The conformations have little effect on the electronic structure of the ground state. The deformed phenyl group in the geometry of the excited state is the excimer‐forming site. The energetically matched HOMO of the excited state with the LUMO of the ground state should cause an attraction to form an excimer. Most conformations are likely to form the excimer but have different contributions to the excimer formation. The interaction of the ground state with the excited state in the excimer has been described quantitatively, which shows that the most stable intermolecular arrangement is the stacked‐eclipsed mode. The excimers display a broad excitation spectrum. The local excitation type is dominant during the excitation, and the charge transfer contributes to the excimer's stability.
A New Strategy for the Synthesis of Porphyrin and Expanded Porphyrin Derivatives from Di‐ and Tripyrromethanes: Antioxidant, Cytotoxic Activity, and Molecular Docking Evaluation
Authors: Abdel‐Wahed Hend M. , Fadda Ahmed A. 
Published: April 2023

AbstractWe present a novel and effective process for producing porphyrins in the absence of a solvent condition, in contrast to earlier procedures. An aldehyde and pyrrole were condensed by grinding in the presence of an acidic catalyst during the synthetic process. By adjusting reactant molar ratios and concentrations, dipyrromethane 3 and tripyrromethane 4 derivatives, the synthesis was improved at room temperature in 5–10 minutes with excellent yields. In this work, we successfully synthesized a number of novel porphyrin derivatives, 6 b–j. Here, we describe a method for reacting dipyrromethane 3a with various aryl aldehydes 5 b–j while using DMF as a capping agent. Moreover, expanding porphyrin derivatives 7 a, and 7 b were synthesized from the reaction of 4a with aldehydes 5a and 5b at 0 °C. Porphyrin derivatives 6 g and 6 h displayed good antioxidant potential. The cytotoxic activity of compounds 6 h, 6 b, and 6c against the human cell lines HePG‐2 and MCF‐7 were studied. The binding modes of the synthesized compounds were analyzed by docking studies that showed good binding scores against the diverse amino acids of the selected proteins (Bcl‐2). The conducted docking studies were found to be consistent with cytotoxic results.
Ultrasound and Pressure Assisted Solid‐State Polymerization of Carbazole
Authors: Avcı Yayla Işık İpek , Sezer Esma , Ustamehmetoğlu Belkıs 
Published: April 2023

AbstractThis study was carried out with the aim of obtaining polycarbazole (PCz) with solid‐state polymerization by using ultrasound and pressure assisted methods. For ultrasound‐assisted method (U), first, the optimum carbazole (Cz) and cerium ammonium nitrate (CAN) amounts, polymerization time, ultrasound application conditions were determined and then the polymers that are called “PCz‐U#” were characterized by using scanning electron microscope (SEM), fourier transform infrared spectroscopy (FT‐IR), thermal gravimetric analysis (TGA), transmission electron microscobe (TEM), X‐ray diffraction (XRD) and four‐point prop conductivity measurements. The effect of the applied pressing time during preparation of pellet on the conductivity of PCz‐U was also investigated. Pressure‐assisted polymerization (P) was carried out at these optimum conditions and the resulting polymer was called “PCz‐P#”.In order to understand the advantage of the ultrasound and pressure assisted methods, conventional polymerization in a solution was also performed at the optimum concentrations of Cz and CAN and the properties of PCz's obtained from three different methods were compared. The conductivities of PCz's obtained in a very short time such as one minute with the ultrasound and pressure assisted methods are at the same level as the conductivity of the polymer (∼10−4 S/cm) obtained by the solution method in 20 minutes using 16 and 35.6 times higher amounds of Cz and CAN, respectively. With this study, two new methods for PCz synthesis have been proposed, which are suitable for VOC limitation as no solvent is used in and environmentally friendly because less chemicals are used.
((E)‐N′(3,5‐di‐tert‐butil‐2‐hedroxybenzilidene)‐2‐hydroxybenzohydrazide (H3sahz)2 Copper (II) Complex: Synthesis, Crystal Structures, in silico Evaluations, and Enzymatic Inhibition
Authors: Fatullayeva Perizad Amrulla , Mejidov Ajdar Akper , Safronenko Marina Gennadievna , Nikolayevich Khrustalev Victor , Yalcin Bahaddin , Sadeghian Nastaran , Sadeghi Morteza , Taslimi Parham 
Published: April 2023

AbstractIn this study, (E)‐N′(3,5‐di‐tert‐butil‐2‐hedroxybenzilidene)‐2‐hydroxybenzohydrazide (H3sahz)2 and its copper (II) complex has been synthesized and evaluated by methods FTIR, UV–Vis, EPR, and single crystal X‐ray analysis. It has been shown, that H3sahz crystallizes as a dimer through hydrogen bonds. H3sahz with copper nitrate forms [Cu(H2sahz)(NO3)(H2O)] complex, which according to X‐ray diffraction analysis has a distorted square pyramidal structure. The complex was screened for α‐glucosidase (α‐Glu), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibitory abilities. Results displayed that IC50 and Ki values of the novel complex for AChE, BChE, and α‐Glu enzymes were obtained at 0.93–2.14, 1.01–2.03, and 73.86–102.65 μM, respectively. The molecular docking outcomes have shown that the synthetic complex has a lower affinity for α‐glucosidase compared to acarbose. But the inhibition ability of H3sahz for acetylcholinesterase and butyrylcholinesterase enzymes was greater than that of tacrine. These findings indicate that the (H3sahz)2 complex may be considered a possible candidate for the development and discovery of compounds effective in inhibiting the relevant enzymes.
Governing crowdsourcing for unconstrained innovation problems
Authors: Zaggl Michael A. , Malhotra Arvind , Alexy Oliver , Majchrzak Ann 
Published: April 2023

AbstractResearch SummaryTheories of crowdsourced search suggest that firms should limit the search space from which solutions to the problem may be drawn by constraining the problem definition. In turn, problems that are not or cannot be constrained should be tackled through other means of innovation. We propose that unconstrained problems can be crowdsourced, but firms need to govern the crowds differently. Specifically, we hypothesize that firms should govern crowds for solving unconstrained problems by instructing them not just to solve the problem but also to help (re)define the problem by offering their problem frames and integrating others' frames. We find evidence for this interaction hypothesis in a field study of over a thousand participants in 20 different crowdsourcing events with interventions for the different governance approaches.Managerial SummaryUnconstrained innovation problems, which require finding a new product and a new market at the same time, are thought to be difficult to solve via crowdsourcing. We propose and test a governance approach for problem‐finding, that is, (re)defining the firm's original problem statement by instructing crowds to make their problem frames explicit (by posting them) and to integrate others’ problem frames into their solution ideas. In doing so, we provide guidance for firms hoping to use crowdsourcing for both unconstrained and constrained problems. For constrained problems, as widely known, firms should govern for problem‐solving only; for unconstrained problems, they should govern for problem‐finding and problem‐solving. Both forms of governance are “light‐touch,” requiring only minimal intervention in the form of instructions for the crowd at the beginning of the crowdsourcing event.
Battery‐Free, Wireless, Cuff‐Type, Multimodal Physical Sensor for Continuous Temperature and Strain Monitoring of Nerve
Authors: Kim Seunghwan , Oh Yong Suk , Lee Kwanghyoung , Kim Seongchan , Maeng Woo‐Youl , Kim Kyung Su , Kim Ga‐Been , Cho Seokjoo , Han Hyeonseok , Park Hyunwoo , Wang Mengqiu , Avila Raudel , Xie Zhaoqian , Ko Kabseok , Choi Jungrak , Je Minkyu , Lee Hyojin , Lee Sungho , Koo Jahyun , Park Inkyu 
Published: April 2023

AbstractPeripheral nerve injuries cause various disabilities related to loss of motor and sensory functions. The treatment of these injuries typically requires surgical operations for improving functional recovery of the nerve. However, capabilities for continuous nerve monitoring remain a challenge. Herein, a battery‐free, wireless, cuff‐type, implantable, multimodal physical sensing platform for continuous in vivo monitoring of temperature and strain from the injured nerve is introduced. The thin, soft temperature, and strain sensors wrapped around the nerve exhibit good sensitivity, excellent stability, high linearity, and minimum hysteresis in relevant ranges. In particular, the strain sensor integrated with circuits for temperature compensation provides reliable, accurate strain monitoring with negligible temperature dependence. The system enables power harvesting and data communication to wireless, multiple implanted devices wrapped around the nerve. Experimental evaluations, verified by numerical simulations, with animal tests, demonstrate the feasibility and stability of the sensor system, which has great potential for continuous in vivo nerve monitoring from an early stage to complete regeneration.
Teaching undergraduate students to think like real‐world systems engineers: A technology‐based hybrid learning approach
Authors: Ghannam Rami , Chan Cecilia 
Published: April 2023

AbstractA hybrid teaching approach that relied on combining Project Based Learning with Team Based Learning was developed in an engineering module during the past 5 years. Our motivation was to expose students to real‐world authentic engineering problems and to steer them away from the classical banking approach, with a view to developing their systems engineering skills via collaborative learning. Our third year module was called Team Design and Project Skills and was concerned with 320 students dividing themselves in teams to develop a smart electronics system. We reveal module design details and discuss the effectiveness of our teaching approach via analysis of student grades during the past 5 years, as well as data from surveys that were completed by 68 students. 64% of surveyed students agreed that the module helped broaden their perspective in electronic systems design. Moreover, 84% recognized that this module was a valuable component in their degree programme. Adopting this approach in an engineering curriculum enabled students to integrate knowledge in areas that included control systems, image processing, embedded systems, sensors, as well as team working, decision making, trouble shooting and project planning.
Endoplasmic reticulum chaperone GRP78 participates in fluoride‐induced autophagy in LS8 cells by regulating the IRE1‐TRAF2‐JNK pathway
Authors: Zhao Lin , Wang Liyuan , Wang Han , Xi Tao , Liu Sijia , Li Yang , Ruan Jianping , Huang Yongqing 
Published: April 2023

AbstractFluoride induces endoplasmic reticulum (ER) stress in ameloblasts, which is responsible for enamel mineralization disorder. Fluoride induces autophagy in ameloblasts, but the molecular mechanisms through which ameloblasts respond to fluoride‐induced cellular stress and autophagy remain unclear. This study investigated ER stress‐induced autophagy and the regulatory role of the ER molecular chaperone GRP78 in fluoride‐induced autophagy in ameloblast LS8 cells. To explore the relationship between fluoride‐induced ER stress and autophagy, we assessed changes in fluoride‐induced autophagy in LS8 cells following overexpression and/or silencing of the ER stress molecular chaperone GRP78. We found that autophagy induced by fluoride was further increased after GRP78 overexpression in LS8 cells. Fluoride‐induced autophagy was reduced in GRP78‐silenced LS8 cells. Furthermore, we found that ER stress can regulate autophagy in fluoride‐treated ameloblasts (LS8 cells) and that the GRP78/IRE1/TRAF2/JNK pathway is involved in the underlying regulation. Our study suggests that ER stress plays a role in fluoride‐induced damage by inducing ameloblast autophagy.
Remarkable effects of silicone rubber on flame retardant property and mechanical properties of crosslinked high‐density polyethylene/bio‐based magnesium phosphate flame retardant (MHPA) composite
Authors: Feng Xi , Wang Zhengyu , Ma Hongli , Dang Bo , Li Jianxi 
Published: April 2023

AbstractIn this paper, a new bio‐based flame retardant MHPA was prepared by the reaction of magnesium hydroxide (MH) and phytic acid (PA). Then the crosslinked high‐density polyethylene (HDPE) flame‐retardant composite was prepared by adding it and silicone rubber (SR) into HDPE and using electron beam irradiation. The test results of limiting oxygen index (LOI) and cone calorimeter test (CCT) show that the combination of MHPA and SR can increase the flame retardancy and smoke suppression performance of HDPE. The LOI of HDPE composite with 10 parts of SR is 28.3%, and its pHRR, THR and TSP values are reduced to 454.1 kW/m2, 99.7 MJ/m2 and 8.3 m2, respectively, which is because MHPA and SR jointly promote the formation of continuous and high‐density carbon slag in the combustion process of HDPE and inhibit the penetration of flame. In addition, the HDPE composite with 10 parts of SR has significant tensile strength, elongation breaking strength and tear strength, because SR can produce continuous stable structure with HDPE after irradiation and crosslinking. Therefore, this study verified that MHPA and SR together can effectively improve the flame retardancy, smoke suppression and mechanical properties of HDPE composite.
CFT duals for black rings and black strings
Authors: Chanson Alexandra , Martin Victoria , Rodriguez Maria J. , Temoche Luis Fernando 
Published: April 2023

Abstract
Holographic dualities between certain gravitational theories in four and five spacetime dimensions and 2D conformal field theories (CFTs) have been proposed based on hidden conformal symmetry exhibited by the radial Klein-Gordon (KG) operator in a so-called near-region limit. In this paper, we examine hidden conformal symmetry of black rings and black strings solutions, thus demonstrating that the presence of hidden conformal symmetry is not linked to the separability of the KG-equation (or the existence of a Killing-Yano tensor). Further, we will argue that these classes of non-extremal black holes have a dual 2D CFT. New revised monodromy techniques are developed to encompass all the cases we consider.
Flat equivariant gerbes: holonomies and dualities
Authors: Cheng Peng , Melnikov Ilarion V. , Minasian Ruben 
Published: April 2023

Abstract
We examine the role of global topological data associated to choices of holonomy for flat gauge fields in string compactification. Our study begins with perturbative string compactification on compact flat manifolds preserving 8 supercharges in 5 dimensions. By including non-trivial holonomy for Wilson lines in the heterotic string and for the B-field gerbe in the type II string we find worldsheet dualities that relate these backgrounds to other string compactifications. While our simple examples allow for explicit analysis, the concepts and some of the methods extend to a broader class of compactifications and have implications for string dualities, perturbative and otherwise.
Exceptional sequences in the derived category of a gentle algebra
Authors: Chang Wen , Schroll Sibylle 
Published: April 2023

AbstractIn this paper, using the correspondence of gentle algebras and dissections of marked surfaces, we study full exceptional sequences in the perfect derived category $${{\,\mathrm{\mathsf {K^b(A)}}\,}}$$

K
b

(
A
)

of a gentle algebra $${{\,\mathrm{\textsf{A}}\,}}$$

A

. We show that full exceptional sequences in $${{\,\mathrm{\mathsf {K^b(A)}}\,}}$$

K
b

(
A
)

exist if and only if the associated marked surface has no punctures and has at least two marked points on the boundary. Furthermore, by using induction on cuts of surfaces, we characterize when an exceptional sequence can be completed to a full exceptional sequence. If the genus of the associated surface is zero then we show that the action of the braid group together with the grading shift on full exceptional sequences in $${{\,\mathrm{\mathsf {K^b(A)}}\,}}$$

K
b

(
A
)

is transitive. For the case of surfaces of higher genus, we reduce the problem of transitivity to the problem of the existence of certain sequences of pairs of exceptional objects. Finally, we interpret the duality of a full exceptional sequence induced by the longest element in the associated symmetric group using Koszul duality.
Development of a 5-HT7 receptor antibody for the rat: the good, the bad, and the ugly
Authors: Thompson Janice M. , Tragge Will , Flood Emma D. , Schulz Stefan , Lisabeth Erika , Watts Stephanie W. 
Published: April 2023

AbstractOur laboratory has a vested interest in measuring the location and expression of the 5-hydroxytryptamine (5-HT, serotonin) 7 (5-HT7) receptor in the rat. Determining tissue-specific receptor expression would aid in validating understood and potentially new tissues that support the 5-HT7 receptor-mediated fall in blood pressure, an event we are committed to understand. We contracted with 7TM Antibodies to develop deliberately and rigorously a rat 5-HT7 (r5-HT7) receptor specific antibody. Three antigens, two targeting the third internal loop and one the C terminus, were used in three rabbits to generate antibodies. As a positive control, HEK293(T or AD) cells were transfected with a plasmid for the r5-HT7 receptor also expressing a C terminus 3xFLAG tag. Naïve rat tissues were also used in Western and immunohistochemical analyses. Nine antibodies (3 from three different rabbits) detected a ~ 75 kDa protein absent in homogenates of vector control HEK293T cells. Only antibodies that recognized the C terminus of the 5-HT7 receptor [ERPERSEFVLQNSDH(Abu)GKKGHDT; antibodies 3, 6, and 9] positively and concentration-dependently identified the r5-HT7 receptor expressed in Westerns of transfected HEK293T cells. These same C terminus antibodies also successfully detected the r5-HT7 receptor in immunocytochemical test of the transfected HEK293AD cells, colocalizing with the detected FLAG sequence. In naive tissue, antibody 6 performed the best, identifying specific bands in the brain cortex in Western analysis. These same antibodies produced a more diverse band profile in the vena cava, identifying 6 major proteins. In immunohistochemical experiments, the same C-terminus antibodies, with antibody 3 performing the best, detected the 5-HT7 receptor in rat veins. This deliberate work has given rise to at least three antibodies that can be used with good confidence in r5-HT7 transfected cells, two antibodies that can be used in immunohistochemical analyses of rat tissues and in Westerns of rat brain; we are less confident of the use of these same antibodies in rat veins.
Laparoscopic deroofing of simple liver cysts: do ancillary techniques, surgical devices, and indocyanine green improve outcomes?
Authors: Kersik Alessia , Galassi Luca , Colombo Giulia , Bonavina Luigi 
Published: April 2023

Summary
Background
Giant liver cysts causing compression symptoms require surgical therapy. Laparoscopy is nowadays considered the first-line approach and has been shown to be non-inferior to open surgery. Ancillary techniques and novel technologies may have the potential to reduce complications rates and improve long-term outcomes.

Methods
The management of a female patient with a giant and symptomatic liver cyst is reported, as is a literature search in PubMed and Scopus spanning the past two decades, with the aim of assessing current evidence regarding procedural details of laparoscopic deroofing.

Results
Wide laparoscopic deroofing of a 21-cm liver cyst arising from segment 6 was safely performed under indocyanine green fluorescence imaging using a combination of ultrasonic energy excision and stapling. A contemporary literature review showed that only 22 of the 35 publications included details of the surgical procedure. Ancillary techniques such as omentopexy, argon plasma coagulation, monopolar radiofrequency device ablation, and ethanol sclerotherapy were rarely used (10.8% of patients). Use of energy devices and/or linear staplers was reported in 22 (62.8%) studies. Indocyanine green fluorescence was reported in 4 (11.4%) studies.

Conclusion
The case report and the literature review show that wide laparoscopic deroofing of giant liver cysts is an effective and relatively simple procedure. Use of emerging technology such as indocyanine green fluorescence imaging can further enhance precision surgery and minimize complications and long-term recurrence rates.