bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Formulation of the Ensemble History-Matching Problem
Authors: Geir Evensen 
Published: March 2023

Abstract
This paper revisits the formulation of the history-matching problem solved using state-of-the-art ensemble methods. It shows how the standard problem formulation is flawed and ignores crucial components, including a stochastic forcing of the ensemble realizations to account for errors in the historical rates and the apparent dependency of the rate data meaning they have correlated errors in time. Also, the paper shows how we can use iterative ensemble smoothers to solve a consistent formulation for the history-matching problem where we augment the rate-control errors to the state vector and estimate them together with the uncertain geologic model parameters. Updating these errors and then using them to force the reservoir simulations leads to an improved posterior ensemble of prediction models that better cover the observations with more substantial and realistic uncertainty. The new formulation derives directly from the sampling of the Bayes’ posterior. The proposed formulation leads to a weaker but more realistic update of the reservoir model parameters. We avoid overfitting, and have a more realistic representation of the ensemble-prediction uncertainty that better covers the historical rates within their errors.
Experimental and Simulation Studies of Cryogenic Effects in the Near-Wellbore Region
Authors: Winterfeld Philip H. , Yao Bowen , Wu Yu-Shu 
Published: March 2023

Abstract
We modified our parallel thermo-hydraulic-mechanical simulator of fully coupled multiphase fluid and heat flow and geomechanics in porous and fractured media to simulate cryogenic fracturing with liquid nitrogen. This included developing a physical property module for nitrogen-water systems and formulating fracture initiation and extension criteria.
We simulated cryogenic fracturing experiments on small concrete blocks to verify the simulator modifications. Then, we simulated two field cases, one with an injector-producer pair with cryogenic fracturing that enhanced the permeability in a vertical plane around the wellbore and extending in the direction of the producer. The second case was cryogenic fracturing and cooling of the near-wellbore region in a shallow, heated reservoir. The induced fractures were horizontal but their lengths were non-uniform due to the pressure and temperature gradients.
An Enriched Galerkin Discretization Scheme for Two Phase Flow on Non-Orthogonal Grids
Authors: Jammoul M. , Alpak F. O. , Wheeler M. F. 
Published: March 2023

Summary
The representation of faults and fractures using cut-cell meshes often results in irregular non-orthogonal grids. Simple finite volume approaches fail to handle complex meshes because they are highly prone to grid orientation effects and only converges for K-orthogonal grids. Wide stencil approaches and higher order methods are computationally expensive and impractical to adopt in commercial reservoir simulators. In this work, we implement an Enriched Galerkin (EG) discretization for the flow and transport problems on non-orthogonal grids. The EG approximation space combines continuous and discontinuous Galerkin methods. The resulting solution lies in a richer space than the the two-point flux approximation (TPFA) method and allows a better flux approximation. It also resolves the inconsistencies that are usually associated with TPFA scheme. The method is tested for various non-orthogonal mesh configurations arising from different fault alignments. The performance of the scheme is also tested for reservoirs with strong anisotropy as well as reservoirs with heterogeneous material properties.
Matrix Formulation for Simultaneous Calculations of Pressure and Temperature in Wells and Pipelines
Authors: Alves Ibere N. , Islam Raka , de Sousa Segundo José Savio Alves 
Published: March 2023

Abstract
This paper presents a novel approach to calculate pressure and temperature profile in a pipe. An implicit formulation is implemented in this model using a combined system of the three conservation equations (mass, momentum, and energy), and using the change of enthalpy and pressure to calculate the change of temperature.
The derivation of the equations for temperature and pressure profile calculation uses the traditional approach of applying the mass, momentum and energy balance equations to a control volume of the pipe. For a pipe, usually the pressure and temperature values at one end are known. Due to the non-linearity of balance equation, an iterative process is required to calculate the values at the other end of the pipe. In the model proposed in this paper the system of equations was arranged in a matrix and vector form, all pressure and temperature for all the nodes are calculated in one calculation step, different from the traditional approach.
The proposed model is used with both Black oil table correlations and a fully compositional model for calculating P-T profiles. It can be applied over the entire inclination angle range from horizontal to vertical. Conventionally, marching algorithm is used to calculate pressure from first cell to second cell until the end of the pipe is reached. The final form of energy balance is expressed in terms of enthalpy; therefore, P-H flash is used to calculate temperature profile. The calculation process is faster as all of it is done in one step and more accurate than the traditional approach.
Traditionally the coupling of the mechanical energy and heat balance equation, uses a marching algorithm to determine pressure and temperature profile in a pipe, using a nested pair of loops, usually the external one for temperature and an internal for pressure. The proposed method applies a novel matrix formulation using a vectorized procedure to determine simultaneously pressure and temperature using their natural connection the enthalpy through the balance equations. This method aims to determine pressure-temperature profiles in a fast and accurate way. Vector and matrices approach is a tool that improves the performance of a code and utilizing it for pipeline calculation is unique, it opens a door for also coupling with reservoir simulators in an integrated approach. Since most flow assurance problems i.e. paraffin, hydrate are related to pressure and temperature dependent, the proper calculation of the P-T profile is a must. The proposed model provides a fast and precise calculation organizing the problem in a structured manner.
Multi-Band Flexible UWB Antenna for Flexible Electronics and Biomedical Applications
Authors: R PRASANNA , G Thamarai Selvi , K Annaram , K Venkatalakshmi 
Published: March 2023

Abstract
This article, proposes a flexible ultra-wide band (UWB) antenna for wearable electronics and biomedical applications. The antenna presented for this work is fabricated on kapton polyimide substrate and the operating frequency band ranges from 2.4GHz to 7.1GHz. The proposed antenna has elliptical radiating element and achieves improved impedance matching characteristics through coplanar waveguide (CPW) fed. A detailed study on choice of substrate is performed and the kapton substrate make the antenna less susceptible for degradation in antenna performance that arises due to bending effects. The measurement and simulated results of the fabricated antenna shows good degree of agreement. The return loss performance of the proposed antenna is greater than − 10dB in all the operating bands with improved gain and directivity. The flexible nature with multiple frequency band of operation and good bending performance makes the proposed antenna appropriate for wearable electronic and biomedical applications.
SNR based Adaptive Quantized Iterative Thresholding for Sparse Approximation
Authors: afkari shabnam , tinati mohammad ali , yusefi tohid 
Published: March 2023

Abstract

Compressed sensing could be considered as one of the most effective compression methods in terms of compression ratio that requires the underlying signal to be sparse or have a sparse representation in an appropriate domain. Sparse coding aims to ﬁnd a sparse set of coefﬁcients that accurately represents a signal from a ﬁxed overcomplete dictionary. In practical signal processing, it is necessary to quantize the sampled signals, therefore quantization is considered as a necessary step to digitize signals and realize the high-efficiency transmission of digital signals. In this paper we present a new method that combines the problems of approximating sparse signals with coefﬁcient quantization. Here we propose a novel Adaptive Quantized Iterative Thresholding (AQIT) method based on SNR (signal-to-noise ratio) derived as an extension of classical iterative thresholding methods to ﬁnd sparse representations of signals. The simulation results compare this method to Quantized Iterative Thresholding (QIT) methods and show a significant improvement in operational SNR performance.
Development of A master teleoperated manipulator for A hydraulic rescue robotic arm
Authors: Zhong Jun , Yi Yongbin , Gong Jin 
Published: March 2023

Abstract

The teleoperated rescue robot system has significant practical value and realistic significance in light of the complicated and hazardous environment following the seismic tragedy. In this study, a master-end manipulator system for teleoperation is conceived and built based on the self-created large-load seven-degree-of-freedom (7-DOFs) hydraulic robotic arm, to give users a simple and practical method of dragging control. First, the master manipulator of the hydraulic rescue robotic arm is designed as a homogeneous seven-axis linkage structure in accordance with the master hand design principle, and the corresponding degrees of freedom are configured in accordance with the configuration and performance index of the redundant degrees of freedom of the slave end hydraulic manipulator arm. Next, we construct the synovial mode impedance control method after analyzing the motion of the actual main-end manipulator arm. The feasibility of the synovial-mode impedance algorithm and the operability of the joystick functioning as the main end of the teleoperation system are next tested through testing. The results demonstrate that, in comparison to the general impedance control, the suggested main-end manipulator may ensure a better traction effect and decrease torque output errors, which in turn enhances operation accuracy.
Beam Steering-Switching Array with Dual-Band Operation for 5G S-Band Adaptive Antenna Applications using SLPS and E-Shape Slot Antenna
Authors: Kodgirwar Vidya Pramod , Joshi Kalyani R. , Deosarkar Shankar B. 
Published: March 2023

Abstract
The proposed research work presents a design of dual-band, 4-element, planer beam-steering antenna array with feed network. The proposed design is carried out with two different schemes for 5G (Lower Band) applications. A design procedure is derived in detail, and a prototype, including the array and a planar feeding network, is built and tested for the second scheme. The array is capable of generating number of beams in different directions based on the ON/OFF state of PIN diodes (MA4SPS402) used in Switched Line Phase Shifters (SLPS). But it is tested for 22 combinations of the SLPSs. The scanning range covered by this array is -45o to + 45o. To cover the entire 360o range, four such array prototypes are sufficient. Inter-element spacing is optimized with D1 = 86mm and D2 = 40mm to achieve maximum directive gain, which is 14.4dBi at 3.6GHz and 11.7dBi at 2.4GHz. Return Loss obtained is -24.89dB at 3.6GHz and − 13.79dB at 2.4GHz. In order to operate the array in two bands, the Slot antenna is designed using Quarter Wave Transformer (QWT) with directive gain of 7.6dBi and 7.39dBi at 3.6 and 2.4GHz respectively. For Designing of feed network, Wilkinson Power Dividers and Switched Line Phase Shifters are used. When the frequency of the excitation signal is 3.6GHz, the direction of maxima is positive and when it is 2.4GHz, the direction of maxima is negative for the E-Plane. Beam switching, based on the phase shift applied to array elements, will be in the H-Plane for both frequency regions.
Vertical Handover-based Hybrid RF/VLC Scheme for e-Health Applications (VHO-HeA)
Authors: SAMARJI NIVINE , Salamah Muhammed 
Published: March 2023

Abstract
Maximizing spectral efficiency and capacity of the conventional radio frequency (RF) systems are critical challenges occurring especially in RF-based indoor wireless communications where high data rate demands arise. Hence, the urge for finding an alternative wireless carrier is the key for exploiting the visible light communication (VLC) bands. However, the main issue incorporated with the usage of VLC band is the high dependency of connectivity on line of sight (LOS). Therefore, hybrid RF/VLC system has been top-hot topic in wireless communication where RF is capable of offering wide-area coverage and VLC has the ability to provide high transmission data rate. This paper presents vertical handover-based hybrid RF/VLC intra-software defined wireless body area network architecture to guarantee the different QoS requirements. Our proposed scheme maintains network reliability by prioritizing the processing of the emergency data. The proposed hard switching algorithm is formulated as multi-objective optimization problem aiming at minimizing the outage and blocking probabilities, worst-case latency, packet error rate, and maximizing the throughput and system fairness. To solve such multi-optimization problem, we have used Pareto simulated annealing to efficiently select either VLC link or RF link satisfying the system constraints. Simulation results show that the proposed hybrid RF/VLC scheme satisfies QoS for WBANs. In comparison with the standalone VLC system, hybrid RF/VLC scheme outperforms the latter for smaller values of signal to interference plus noise ratio. Better network performances were recorded in comparison with other state-of-the-art schemes.
PDI augments kainic acid-induced seizure activity and neuronal death by inhibiting PP2A-GRIA2-PICK1-mediated AMPA receptor internalization in the mouse hippocampus
Authors: Lee Duk-Shin , Kim Tae-Hyun , Park Hana , Kim Ji-Eun 
Published: March 2023

AbstractProtein disulfide isomerase (PDI) is a redox-active enzyme and also serves as a nitric oxide (NO) donor causingS-nitrosylation of cysteine residues in various proteins. Although PDI knockdown reducesα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR)-mediated neuronal activity, the underlying mechanisms are largely unknown. In the present study, we found that under physiological condition PDI knockdown increased CaMKII activity (phosphorylation) in the mouse hippocampus. However, PDI siRNA inhibited protein phosphatase (PP) 2A-mediated GRIA2 S880 dephosphorylation by increasing PP2A oxidation, independent ofS-nitrosylation. PDI siRNA also enhanced glutamate ionotropic receptor AMPA type subunit 1 (GRIA1) S831 and GRIA2 S880, but not GRIA1 S845 and GRIA2 Y869/Y873/Y876 phosphorylations, concomitant with the enhanced protein interacting with C kinase 1 (PICK1)-mediated AMPAR internalization. Furthermore, PDI knockdown attenuated seizure activity and neuronal damage in response to kainic acid (a non-desensitizing agonist of AMPAR). Therefore, these findings suggest that PDI may regulate surface AMPAR expression through PP2A-GRIA2-PICK1 signaling pathway, and that PDI may be one of the therapeutic targets for epilepsy via AMPAR internalization without altering basal neurotransmission.
Effect of Environmental Factors on Expression of Staphylococcal Enterotoxins Genes
Authors: LI Hong na , KANG Zhao di , WANG Tao , LI Tao , YANG Yan ge , ZHOU Wei e , YUAN Fei 
Published: March 2023

Abstract
Staphylococcal enterotoxins (SEs) secreted by S. aureus can cause foodborne disease, nausea, vomiting and diarrhea and even death. Regulation of SEs Expression is related to accessory gene regulators (Agr). It is important that revealing which environmental factors influencing on regulation of SEs expression to prevention of SEs food poisoning outbreak. Hence, natural environment factors which may be impact on SEs expression were selected, such as Temperature, food types, strains and competing strains. Seven strains of S. aureus carrying different SEs genes were collected from CAIQ strain bank for study. Strains were cultured with different conditions. Temperature, 8℃, 22℃, and 30℃. Food type, milk powder, and nutrient broth. Competing strains, V. parahaemolyticus, E. coli and B. cereus. The expression culture solution was pretreated by centrifugation, then determined by using SDS-PAGE, and distinguished SEs apart from each other by HPLC-ESI-TOF. There are 168 samples collected from SEs expression culture, the result of SDS-PAGE suggests 23 samples were positive for SEs, the other 145 samples were negative for SEs. The result of HPLC-ESI-TOF suggests that SEs with similar molecular weight can be distinguished by in term of m/z. The most important factor contributing to regulate expression of SEs was estimated by regressive analysis. The result shows that R2 was 0.14, F was 6.631 (p＜0.05), this result illustrates that at least one of the factors, strains, food types, temperature, and competing strains was responsible for SEs expression. The regression coefficients of four factors were -0.060 (p＜0.05), -0.074 (p＜0.05), 0.170 (p＜0.05) and 0.060 (p＞0.05). According to regression coefficients, competing strains is not significant influencing on SEs expression, and temperature is key factor for stimulating SEs expression, and had high expression at 30℃. Consequently, food easy contaminated with S. aureus should be monitored intensively at early and late summer, when proper temperature for expressing SEs may results in S. aureus food poisoning prevalence.
Providers’ insight into quality mental health services– Context- Mechanism-Outcome (CMO) approach
Authors: Badu Eric , O’Brien Anthony Paul , Mitchell Rebecca , Osei Akwasi 
Published: March 2023

Abstract

Introduction:
Evaluation frameworks are relevant to understanding health service providers’ views regarding existing services and possible improvements, but their application to mental health services is limited, particularly in Low Middle-Income Countries.
Aim/Question:
To identify program theory for understanding contextual factors and mechanisms that could enhance mental health service outcomes in Ghana.
Method
A three-phase approach was followed: initial theory and assumption, analysis, and CMO configuration. Systematic reviews were used to develop a middle-range theory and assumptions in phase 1. A purposive sample of 30 mental health professionals was recruited to participate in in-depth interviews in phase 2. Thematic analysis was used to analyze the qualitative data and further configure the CMO in phase 3.
Results
The analysis identified five CMO configurations: ripple effects and financing source sustainability; unavailability of modern equipment and logistics to support holistic services; promoting inclusivity and geographical proximity of services; information, sensitization, and awareness encourage mental health quality; and monitoring and evaluating improve mental health service quality.
Discussion/Implications for Practice:
This study concludes that government stakeholders should integrate mental health services into the ongoing insurance policy and provide adequate modern equipment and logistics. Moreover, mechanisms and priorities given to vulnerable consumers should be integrated into policies.
CrebH protects against liver injury associated with colonic inflammation via modulation of exosomal miRNA
Authors: Lee Sang-Hee , Moon Sung-Je , Woo Seung Hee , Ahn Gwangsook , Kim Won Kon , Lee Chul-Ho , Hwang Jung Hwang 
Published: March 2023

Abstract
Background
Hepatic liver disease, including primary sclerosing cholangitis (PSC), is a serious extraintestinal manifestations of colonic inflammation. Cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CrebH) is a transcription factor expressed mostly in the liver and small intestine. However, CrebH’s roles in the gut–liver axis remain unknown.
Methods
Inflammatory bowel disease (IBD) and PSC disease models were established in wild-type and CrebH-/- mice treated with dextran sulfate sodium, dinitrobenzene sulfonic acid, and diethoxycarbonyl dihydrocollidine diet, respectively. RNA sequencing were conducted to investigate differential gene expression. Exosomes were isolated from plasma and culture media. miRNA expression profiling was performed using the NanoString nCounter Mouse miRNA Panel. Effects of miR-29a-3p on adhesion molecule expression were investigated in bEnd.3 brain endothelial cells.
Results
CrebH-/- mice exhibited accelerated liver injury without substantial differences in the gut after administration of dextran sulfate sodium (DSS), and had similar features to PSC, including enlarged bile ducts, enhanced inflammation, and aberrant MAdCAM-1 expression. Furthermore, RNA-sequencing analysis showed that differentially expressed genes in the liver of CrebH-/- mice after DSS overlapped significantly with genes changed in PSC-liver. Analysis of plasma exosome miRNA isolated from WT and CrebH-/- mice indicates that CrebH can contribute to the exosomal miRNA profile. We also identified miR-29a-3p as an effective mediator for MAdCAM-1 expression. Administration of plasma exosome from CrebH-/- mice led to prominent inflammatory signals in the liver of WT mice with inflammatory bowel disease (IBD).
Conclusions
CrebH deficiency led to increased susceptibility to IBD-induced liver diseases via enhanced expression of adhesion molecules and concomitant infiltration of T lymphocytes. Exosomes can contribute to the progression of IBD-induced liver injury in CrebH-/- mice. These study provide novel insights into the role of CrebH in IBD-induced liver injury.
Preoperative neutrophil-to-lymphocyte predicts the prognosis of stage I non-small cell lung cancer
Authors: Chen Fangjun , Zhang Jin , Liu Deruo , Liang Chaoyang , Qiang Guangliang 
Published: March 2023

Abstract
Objective

To investigate the correlation of neutrophil-to-lymphocyte ratios (NLR) with prognosis of stage I non-small cell lung cancer (NSCLC).

Methods.

Clinical data from 567 stage I NSCLC patients who received surgical treatment in our hospital from May 2007 to May 2014 were analyzed retrospectively. According to preoperative peripheral blood NLR values, patients were divided into low- and high-NLR groups. Univariate and multivariate survival analyses were performed to evaluate the correlation of preoperative NLRs with postoperative survival.

Results.

NLRs ranged from 0.48 to 47.25 (median 2.19). The five-year survival for patients in the high-NLR (NLR > 2.19) and low-NLR (NLR < 2.19) groups were 75.7% and 87.3%, respectively, showing significant difference (P = 0.004). Univariate analysis confirmed that age, gender, smoking history, histological tumor type and tumor size, vascular and visceral pleural invasion, and NLRs were prognostic factors for stage I NSCLC. Cox multivariate regression analysis revealed that age, gender, tumor size, vascular and visceral pleural invasion, and NLRs were independent prognostic risk factors for stage I NSCLC.

Conclusion.

NLR may be an independent prognostic factor for stage I NSCLC and elevated NLR is associated with poor prognosis.