bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of ribosomal protein networks in ribosome dynamics
Authors: Timsit Youri , Sergeant-Perthuis Grégoire , Bennequin Daniel 
Published: January 2025

Abstract
Accurate protein synthesis requires ribosomes to integrate signals from distant functional sites and execute complex dynamics. Despite advances in understanding ribosome structure and function, two key questions remain: how information is transmitted between these distant sites, and how ribosomal movements are synchronized? We recently highlighted the existence of ribosomal protein networks, likely evolved to participate in ribosome signaling. Here, we investigate the relationship between ribosomal protein networks and ribosome dynamics. Our findings show that major motion centers in the bacterial ribosome interact specifically with r-proteins, and that ribosomal RNA exhibits high mobility around each r-protein. This suggests that periodic electrostatic changes in the context of negatively charged residues (Glu and Asp) induce RNA–protein ‘distance-approach’ cycles, controlling key ribosomal movements during translocation. These charged residues play a critical role in modulating electrostatic repulsion between RNA and proteins, thus coordinating ribosomal dynamics. We propose that r-protein networks synchronize ribosomal dynamics through an ‘electrostatic domino’ effect, extending the concept of allostery to the regulation of movements within supramolecular assemblies.
Considering Islamic Frameworks to Infectious Disease Prevention
Authors: Irfan Bilal , Khleif Ahmad , Badarneh Jad , Abutaqa Jana , Allam Ali , Kweis Shueib , Tarab Basel , Abu Shammala Abdallah , Nasser Elias , Shweiki Sameeha , Wajahath Muaaz , Padela Aasim 
Published: January 2025

Abstract
Infectious diseases remain a significant global health challenge, particularly in Muslim-majority countries, where socio-economic disparities, urbanization, and conflict exacerbate the spread of illnesses such as dengue, cholera, malaria, and COVID-19. This review explores the potential of Islamic concepts such as taharah (cleanliness), la darar wa la dirar (prevention of harm), and maslahah (communal benefit), as frameworks for infectious disease prevention. These values may align with public health goals, offering religiously resonant approaches to health promotion while addressing the ethical complexities of integrating religious beliefs with biomedical imperatives. The paper examines how community health workers (CHWs) and religious leaders can collaborate to deliver health education, promote vaccination, and manage disease outbreaks, particularly in underserved regions where trust in certain institutions is limited. Challenges arise in ensuring inclusivity, avoiding stigmatization, and balancing the utility of religion in optimal medical end-goals. The ethical implications of using religious messaging in public health campaigns are critically analyzed, emphasizing the need for careful framing to avoid coercion while addressing public benefit. By synthesizing existing literature and case studies, this review highlights how Islamic frameworks may be used to support effective, ethical, and sustainable infectious disease prevention for various stakeholders, offering valuable insights for public health strategies.
Trajectories of Resilience-Related Traits and Their Impact on Health Outcomes in Schizophrenia: Results From a 4-Year Longitudinal Study
Authors: Lee Ellen E , Wu Tsung-Chin , Ibrahim Stephanie , Van Dyne Angelina , Tu Xin M , Eyler Lisa T 
Published: January 2025

Abstract

Background and Hypothesis
For the rapidly growing population of older people living with schizophrenia (PLWS), psychological resilience, or the capacity to adapt to adversity, is an understudied target for improving health. Little is known about resilience and its longitudinal impact on outcomes among PLWS. This study assesses trajectories of resilience-related traits in PLWS and a nonpsychiatric comparison group (NCs) and longitudinal interactions between resilience and health.

Study Design
This sample included 166 PLWS and 155 NCs (mean age 48 years, 52% women), with a 4.1-year mean follow-up time. The groups were comparable in age, sex, and follow-up time. We assessed resilience-related traits, physical well-being, obesity, hyperglycemia, positive symptoms, and negative symptoms. We conducted linear mixed-effects models to examine linear trends over time and continuous-time structural equation models (CTSEM) to assess the longitudinal relationships (cross-lagged effects between resilience and health).

Study Results
People living with schizophrenia had lower resilience levels, compared with NCs. While resilience was stable over time for White individuals, younger non-White individuals with less education had increases in resilience over time. We found bidirectional 1-year cross-lagged effects of resilience with physical well-being and obesity, but not with hyperglycemia. Among PLWS, there were 1-year cross-lagged effects of resilience with both positive symptoms and negative symptoms.

Conclusions
These findings highlight the importance of resilience and its link to physical and mental health over time. Resilience may be a key protective factor in aging among PLWS, and the potential to improve resilience is an important and understudied approach for improving outcomes for older PLWS.
Blunted Ventral Striatal Reactivity to Social Reward Is Associated with More Severe Motivation and Pleasure Deficits in Psychosis
Authors: Shackman Alexander J , Smith Jason F , Orth Ryan D , Savage Christina L G , Didier Paige R , McCarthy Julie M , Bennett Melanie E , Blanchard Jack J 
Published: January 2025

Abstract

Background and Hypothesis
Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a central role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences.

Study Design
Here we leveraged parallel social and monetary incentive delay functional magnetic resonance imaging paradigms to test whether blunted reactivity to social incentives in the ventral striatum—a key component of the distributed neural circuit mediating appetitive motivation and hedonic pleasure—is associated with more severe MAP symptoms in a transdiagnostic adult sample enriched for psychosis. To maximize ecological validity and translational relevance, we capitalized on naturalistic audiovisual clips of an established social partner expressing positive feedback.

Study Results
Although both paradigms robustly engaged the ventral striatum, only reactivity to social incentives was associated with clinician-rated MAP deficits. This association remained significant when controlling for other symptoms, binary diagnostic status, or striatal reactivity to monetary incentives. Follow-up analyses suggested that this association predominantly reflects diminished activation during the presentation of social reward.

Conclusions
These observations provide a neurobiologically grounded framework for conceptualizing the social-anhedonia symptoms and social impairments that characterize many individuals living with psychotic disorders and underscore the need to develop targeted intervention strategies.
Risk Estimation of Carcinogenic and Noncarcinogenic Diseases from Radiation for Medical X-ray Workers
Authors: Liu Gang , Li Ye , Wu XiaoQin , Liu YinYin , Zhang Rong , Niu LiMei , Zhang Xue , Wang Jinhan , Gu Yeqing 
Published: January 2025

Abstract
The objective of this paper is to construct a follow-up cohort of medical x-ray workers and analyze the risk estimates of radiation-induced carcinogenic and noncarcinogenic diseases induced by chronic low-dose ionizing radiation exposure in the follow-up cohort. A fixed cohort study was used. A total of 159 medical x-ray workers working in radiology departments of hospitals in Gansu Province from 1950 to 1980 were selected as the radiology group, and 149 medical workers in internal medicine, surgery, and other departments who had not engaged in radiology work at the same hospital were selected as the control group. A fifth follow-up survey was also conducted. Information on personal radiation exposure history, lifestyle and morbidity was collected for 310 medical x-ray workers and the control group. Malignant tumors and noncancerous diseases (cataracts, diabetes, aplastic anemia, hypertension, coronary heart disease, cerebral apoplexy, etc.) were used as endpoints to analyze the risk estimates of carcinogenic and noncancerous diseases caused by low-dose radiation. There were 14 patients with malignant tumors, 8 in the radiation group and 6 in the control group (RR=1.25); 11 cases of cataract, radiation group, 8 cases, control group, 3 cases, RR:2.50; 18 patients with diabetes mellitus, 12 in the radiation group and 6 in the control group (RR = 1.87); 25 hypertensive patients, 17 in the radiation group and 8 in the control group (RR = 1.99); 23 patients with CHD, 12 in the radiation group and 11 in the control group (RR = 1.02); and 15 cerebral apoplexy patients, 5 in the radiation group and 10 in the control group (RR=0.47).Compared with the control group, the differences were statistically significant (P<0.01). The risk factors for CR and noncarcinogenic diseases associated with low-dose radiation were cataracts (RR: 2.50) > hypertension (RR: 1.99) > diabetes (RR: 1.87) > malignancy (RR: 1.25) > CHD (RR: 1.02) > cerebral apoplexy (RR: 1.02). 0.47. Compared with those in the control group, medical x-ray workers had an increased risk of developing malignant tumors and cataracts, which may be related to occupational exposure to chronic low-dose ionizing radiation. Therefore, radiation workers should pay attention to the optimization of protection in radiation work practice. The incidences of hypertension and diabetes are increased, and the incidences of CHD are basically the same; in particular, the incidence of cerebral apoplexy is significantly reduced, indicating that cerebral apoplexy has a certain protective effect on medical x-ray workers.
Stigmatized HIV Over Knowledge and Support: A Quantitative Study to Develop and Measure Bangladeshi Women's Social Support When Living With HIV-Related Stigma
Authors: Sultana Shirin , Wade Carol H. , Aguilar Jemel P. 
Published: January 2025

Abstract
Recognizing the unique context of Bangladeshi women living with HIV-related stigma in a patriarchal society is central to social scientists developing a culturally appropriate instrument for examining the impact of meaningful interventions. Working with 200 Bangladeshi women with HIV who responded to 77 items from three instruments, we used exploratory factor analysis and identified five latent constructs: emotional support, felt normative stigma, incorrect HIV transmission knowledge, correct HIV transmission knowledge, and tangible support. Confirmatory factor analysis model specifications for the Comparative Fit Index, Tucker Lewis Index (TLI), and Root Mean Square Error of Approximation (RMSEA) were analyzed and all moderately fit. We thus present the Stigmatized HIV Over Knowledge and Support (SHOKS) model as pioneering work facilitating social scientists in developing a culturally appropriate instrument to generate interventions and better support Bangladeshi women living with HIV-related stigma.
Social Determinants of Health and Unmet Needs for Services among Young Adults with HIV: Medical Monitoring Project, 2018-2021
Authors: Marcus Ruthanne , Dasgupta Sharoda , Taussig Jennifer , Tie Yunfeng , Nair Priya , Prejean Joseph 
Published: January 2025

Background:
Persons aged 13-24 years are a priority population in the National HIV/AIDS Strategy. Young adults with HIV have poorer health outcomes—including not being retained in care, antiretroviral nonadherence, and not being virally suppressed—than other persons with HIV.

Setting:
Centers for Disease Control and Prevention’s Medical Monitoring Project data collected June 2018 through May 2022.

Methods:
We compared demographic characteristics, social determinants of health (SDOH), and mental health between persons aged 18-24 years with HIV versus persons aged ≥25 years with HIV. Among those aged 18-24 years, we analyzed total and unmet needs for ancillary services, defined as those that support care engagement, viral suppression, and overall health and well-being among people with HIV.

Results:
Persons aged 18-24 years were more likely to have a household income <100% of the federal poverty level (48% vs. 39%), and experience unstable housing or homelessness (37% vs. 18%) or hunger/food insecurity (29% vs. 18%) than those aged ≥25 years. Persons aged 18-24 years had higher median HIV stigma scores (40 vs. 29) and were more likely to experience symptoms of generalized anxiety disorder (21% vs. 15%) than those aged ≥25 years. Of persons aged 18-24 years, 96% had a need for ≥1 ancillary service, of whom 56% had ≥1 unmet need; unmet needs were highest for subsistence services (53%) and non-HIV medical services (41%).

Conclusions:
Addressing unmet needs for subsistence and non-HIV medical services could help reduce disparities in SDOH and mental health that drive inequities in health outcomes among persons with HIV aged 18-24 years.
Impact of American College of Surgeons trauma verification on statewide collaborative outcomes
Authors: Mlaver Eli , Atkins Elizabeth V. , Medeiros Regina S. , Sharma Jyotirmay , Solomon Gina , Galloway Luke , Todd Samual R. , Dunne James R. , Ashley Dennis W. ,   the Georgia Research Institute for Trauma Study Group
Published: January 2025

BACKGROUND
American College of Surgeons (ACS) trauma center verification has demonstrated improved outcomes at individual centers, but its impact on statewide Trauma Quality Improvement Program (TQIP) Collaboratives is unknown. A statewide TQIP Collaborative, founded in 2011, noted underperformance in six of eight patient cohorts identified in the TQIP Collaborative report. We hypothesized that requiring ACS verification for level I and II trauma centers would result in improved outcomes for the state collaborative.

METHODS
The ACS verification requirement was tied to ongoing Trauma Commission funding. Trauma centers were required to apply for an ACS consultative visit by 2017 and were given until 2023 to achieve ACS verification. The effect of this intervention was measured in the number of centers achieving verification and in the performance of the TQIP Collaborative semiannual reports.

RESULTS
In 2015, only 1 of 15 (7%) trauma centers were ACS verified, and 4 had undergone consultative visits. By 2023, 11 of 12 (92%) trauma centers achieved ACS verification. Following this intervention, the observed-to-expected odds ratio for all-patient morbidity and mortality improved from 1.60 to 1.17, and variation among patient-specific cohorts narrowed from 0.97–1.82 to 0.96–1.48 (Figure 2). Performance in all six underperforming patient-specific cohorts improved over the study period.

CONCLUSION
ACS verification for level I and II trauma centers improves TQIP Collaborative performance. Statewide Collaboratives should consider ACS verification as a requirement for participation.

LEVEL OF EVIDENCE
Economic and Value-Based Evaluations; Level III.
The utility of the Living Planet Index as a policy tool and for measuring nature recovery
Authors: McRae Louise , Cornford Richard , Marconi Valentina , Puleston Hannah , Ledger Sophie E.H. , Deinet Stefanie , Oppenheimer Philippa , Hoffmann Mike , Freeman Robin 
Published: January 2025

The Living Planet Index (LPI) is a leading global biodiversity indicator based on vertebrate population time series. Since it was first developed over 25 years ago, the LPI has been widely used to indicate trends in biodiversity globally, primarily reported every two years in the Living Planet Report. Based on relative abundance, a sensitive metric of biodiversity change, the LPI has also been applied as a tool for informing policy and used in assessments for several multilateral conventions and agreements, including the Convention on Biological Diversity 2010 Biodiversity Target and Aichi targets. Here, we outline all current and some potential uses of the LPI as a policy tool and explore the use of the LPI in policy documents to assess the reach of the LPI geographically and over time. We present limitations to the use of this indicator in policy, primarily relating to the development of the index at the national level, and suggest clear pathways to broaden the utility of the LPI and the underlying database for temporal and spatial predictions of biodiversity change. We also provide evidence that the LPI can detect recoveries in biodiversity and suggest its suitability for measuring progress towards the goal of biodiversity recovery by 2050.
This article is part of the discussion meeting issue ‘Bending the curve towards nature recovery: building on Georgina Mace's legacy for a biodiverse future’.
A global biogeographic regionalization for butterflies
Authors: Gross Collin P. , Wright April M. , Daru Barnabas H. 
Published: January 2025

The partitioning of global biodiversity into biogeographic regions is critical for understanding the impacts of global-scale ecological and evolutionary processes on species assemblages as well as prioritizing areas for conservation. However, the lack of globally comprehensive data on species distributions precludes fine-scale estimation of biogeographical regionalization for numerous taxa of ecological, economic and conservation interest. Using a recently published phylogeny and novel curated native range maps for over 10 000 species of butterflies around the world, we delineated biogeographic regions for the world’s butterflies using phylogenetic dissimilarity. We uncovered 19 distinct phylogenetically delimited regions (phyloregions) nested within 6 realms. Regional boundaries were predicted by spatial turnover in modern-day temperature and precipitation seasonality, but historical climate change also left a pronounced fingerprint on deeper- (realm-) level boundaries. We use a culturally and ecologically important group of insects to expand our understanding of how historical and contemporary factors drive the distribution of organismal lineages on the Earth. As insects and global biodiversity more generally face unprecedented challenges from anthropogenic factors, our research provides the groundwork for prioritizing regions and taxa for conservation, especially with the goal of preserving the legacies of our biosphere’s evolutionary history.
This article is part of the discussion meeting issue ‘Bending the curve towards nature recovery: building on Georgina Mace's legacy for a biodiverse future’.
Clustered warming tolerances and the nonlinear risks of biodiversity loss on a warming planet
Authors: Williamson Joseph , Lu Muyang , Camus M. Florencia , Gregory Richard D. , Maclean Ilya M. D. , Rocha Juan C. , Saastamoinen Marjo , Wilson Robert J. , Bridle Jon , Pigot Alex L. 
Published: January 2025

Anthropogenic climate change is projected to become a major driver of biodiversity loss, destabilizing the ecosystems on which human society depends. As the planet rapidly warms, the disruption of ecological interactions among populations, species and their environment, will likely drive positive feedback loops, accelerating the pace and magnitude of biodiversity losses. We propose that, even without invoking such amplifying feedback, biodiversity loss should increase nonlinearly with warming because of the non-uniform distribution of biodiversity. Whether these non-uniformities are the uneven distribution of populations across a species’ thermal niche, or the uneven distribution of thermal niche limits among species within an ecological community, we show that in both cases, the resulting clustering in population warming tolerances drives nonlinear increases in the risk to biodiversity. We discuss how fundamental constraints on species’ physiologies and geographical distributions give rise to clustered warming tolerances, and how population responses to changing climates could variously temper, delay or intensify nonlinear dynamics. We argue that nonlinear increases in risks to biodiversity should be the null expectation under warming, and highlight the empirical research needed to understand the causes, commonness and consequences of clustered warming tolerances to better predict where, when and why nonlinear biodiversity losses will occur.
This article is part of the discussion meeting issue ‘Bending the curve towards nature recovery: building on Georgina Mace’s legacy for a biodiverse future’.
Impacts of limits to adaptation on population and community persistence in a changing environment
Authors: Chevin Luis-Miguel , Bridle Jon 
Published: January 2025

A key issue in predicting how ecosystems will respond to environmental change is understanding why populations and communities are able to live and reproduce in some parts of ecological and geographical space, but not in others. The limits to adaptation that cause ecological niches to vary in position and width across taxa and environmental contexts determine how communities and ecosystems emerge from selection on phenotypes and genomes. Ecological trade-offs mean that phenotypes can only be optimal in some environments unless these trade-offs can be reshaped through evolution. However, the amount and rate of evolution are limited by genetic architectures, developmental systems (including phenotypic plasticity) and the legacies of recent evolutionary history. Here, we summarize adaptive limits and their ecological consequences in time (evolutionary rescue) and space (species’ range limits), relating theoretical predictions to empirical tests. We then highlight key avenues for future research in this area, from better connections between evolution and demography to analysing the genomic architecture of adaptation, the dynamics of plasticity and interactions between the biotic and abiotic environment. Progress on these questions will help us understand when and where evolution and phenotypic plasticity will allow species and communities to persist in the face of rapid environmental change.
This article is part of the discussion meeting issue ‘Bending the curve towards nature recovery: building on Georgina Mace's legacy for a biodiverse future’.
SRSF2 transcriptional function maintains genome integrity during cell
division
Authors: Wagner Rebecca E. , Arnetzl Leonie , Britto-Borges Thiago , Heit-Mondrzyk Anke , Bakr Ali , Sollier Etienne , Panten Jasper , Delaunay Sylvain , Sohn Daniela , Schmezer Peter , Odom Duncan T. , Müller-Decker Karin , Dieterich Christoph , Lutsik Pavlo , Bornelöv Susanne , Frye Michaela 
Published: January 2025

Abstract
Recurrent mutations in serine / arginine-rich splicing factor 2 (SRSF2),
particularly the proline-to-histidine substitution at position 95 (P95H), have
been proposed to drive neoplastic diseases. SRSF2 plays pivotal roles in
pre-mRNA processing and gene transcription. However, the precise impact of these
diverse functions of SRSF2 on cancer cell behaviour remains unclear. Here, we
show that deletion or homozygous P95H mutation
ofSRSF2both cause extensive DNA damage leading to
cell cycle arrestin vitroandin
vivo,regardless of cell genotype. We mechanistically
demonstrate that SRSF2 is required for efficient bi-directional transcription of
DNA replication and repair genes, independent of its function in splicing. In
contrast, SRSF2 haploinsufficiency induces DNA damage without halting the cell
cycle in cancer cells. Inducing the
heterozygousSrsf2P95H mutation leads to clonal
expansion of epidermal cells in mouse skin, but tumor formation is inhibited
following exposure to carcinogens. To survive carcinogen treatment, cells
containing theSrsf2P95H mutation undergo substantial
transcription rewiring that restores bi-directional gene expression. Thus, our
study reveals crucial roles of SRSF2 beyond splicing and underscores its
importance in regulating transcription to orchestrate the cell cycle along with
the DNA damage response.