bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF THE CHARACTER OF JESUS IN MARK 4:35-8:30
Authors: Ferry Hartono  
Published: June 2023

Yesus ditampilkan Injil Markus sebagai karakter yang misterius. Studi tentang kemisteriusan pribadi Yesus semakin menanjak belakangan ini sejak Wrede mengungkapkan teori tentang “Rahasia Mesianis”-nya. Analisis karakter Yesus secara naratif dalam artikel ini merupakan salah satu upaya terfokus untuk membantu mengungkit beberapa aspek dari “Rahasia” ini. Saya menggunakan metode analisis karakter yang dirancang oleh Malbon, yang berfokus pada performa karakter, dalam hal ini Yesus. Analisis ini menaruh perhatian pada apa yang karakter-karakter lain katakan kepada dan tentang Yesus; apa tanggapan Yesus; apa yang Yesus lakukan, serta apa karakter-karakter lain lakukan sebagai tanggapan atas kata dan tindakan Yesus. Pembahasan hanya dibatasi atas Mrk 4:35-8:30 karena dalam bagian inilah terjadi proses identifikasi karakter Yesus yang berpuncak pada pengakuan Petrus atas Kemesiasan Yesus. Proses ini tampak terkait secara hakiki dengan tonggak peristiwa misi pertama Yesus ke seberang, yang notabene merupakan daerah orang non-Yahudi. Hasil dari studi ini menunjukkan karakter Yesus yang familiar, meneguhkan beberapa fakta yang sudah ada sebelumnya, sekaligus menyajikan aspek-aspek yang mungkin mengejutkan.
JESUS’ WAY OF COMMUNICATING IN THE CORE OF MEDIA SOCIAL COMMUNICATION SPHERE
Authors: Paulinus Seso  
Published: June 2023

Kita tidak cukup hanya menggunakan media sosial semata-mata untuk mewartakan Injil dan menyampaikan ajaran asli Gereja. Tetapi kita perlu mengkomunikasikan pewartaan dan ajaran tersebut dengan teknik, bahasa, dan psikologi baru dengan menggunakan aksioma dan cara Yesus berkomunikasi. Tujuannya adalah untuk mengenerasi komunikasi otentik bagi kemajuan, unitas, dan keutuhan hidup manusia sebagai tujuan utama dari media sosial sebagai anugerah Allah.
Physiologic effects of surgical masking in children versus adults
Authors: Brooks J Patrick , Layman Jill , Willis Jessica 
Published: June 2023

Background
Surgical masks remain a focal part of the CDC guidelines to decrease COVID-19 transmission. Evidence refuting significant effects of masking on ventilation is mostly limited to small studies, with a paucity of studies on children, and none comparing children to adults.

Methods
A total of 119 subjects were enrolled (71 adults, 49 children) in a prospective interventional study with each subject serving as their own mask-free control. End tidal CO2 (ETCO2), inspired CO2 (ICO2), and respiratory rate were measured by nasal cannula attached to an anesthesia machine D-fend module. Pulse oximetry and heart rate were also followed. After the mask-free period, an ASTM Level 3 disposable surgical mask was donned and 15 min of mask-worn data were collected.

Results
A steady state was confirmed for ETCO2 and ICO2 over the masked period, and mean ICO2 levels rose significantly (p < 0.001) after masking in all age groups. The increase in ICO2 for the 2- to 7-year-old group of 4.11 mmHg (3.23–4.99), was significantly higher (p < 0.001) than the final ΔICO2 levels for both the 7- to 14-year-old group, 2.45 mmHg (1.79–3.12), and adults, 1.47 mmHg (1.18–1.76). For the pediatric group there was a negative, significant correlation between age and ΔICO2, r = −0.49, p < 0.001. Masking resulted in a statistically significant (p < 0.01) rise in ETCO2 levels of 1.30 mmHg in adults and 1.36 mmHg in children. The final respective ETCO2 levels, 34.35 (33.55–35.15) and 35.07 (34.13–36.01), remained within normal limits. Pulse oximetry, heart rate, and respiratory rate were not significantly affected.

Discussion
The physiology of mechanical dead space is discussed, including the inverse relationship of subject age vs ICO2. The methodology and results are compared to previously published studies which detracted from the physiologic safety of surgical masking.

Conclusions
The wearing of a surgical mask results in a statistically significant rise in ICO2 and a smaller rise in ETCO2. Because ETCO2 and other variables remain well within normal limits, these changes are clinically insignificant.
Inverse Hamza Distribution: Properties and Applications to Lifetime Data
Authors: Frank Okpala I. , Obiora-Ilouno Happiness O. , Frederick Omoruyi A. 
Published: June 2023

In this paper, a new distribution, named ‘the Inverted Hamza distribution’, was introduced. It is an extension of the Hamza distribution that can model real-world data with an upside-down bathtub shape and heavy tails. Mathematical and statistical characteristics such as the quantile function, moments, entropy measure, stochastic ordering and distribution of order statistics have been derived. Furthermore, dependability measures such as the survival function and hazard function have been developed. The greatest likelihood technique was used to estimate the distribution parameters. To demonstrate the applicability of the distribution, a numerical example was given. According on the results, the proposed distribution outperformed the competing distributions.
Spherical Lithium Deposition Enables High Li‐Utilization Rate, Low Negative/Positive Ratio, and High Energy Density in Lithium Metal Batteries
Authors: Wang Caoyu , Yang Chunpeng , Du Yahao , Guo Zaiping , Ye Huan 
Published: June 2023

AbstractLithium metal battery promises an attractively high energy density. A high Li‐utilization rate of Li metal anode is the prerequisite for the high energy density and avoiding a huge waste of the Li resource. However, the dendritic Li deposition gives rise to “dead Li” and parasitic interfacial reactions, resulting in a low Li utilization rate. Herein, Li deposition is regulated to spherical Li by designing an MXene host with an egg‐box structure, suitable curvature, and continuous gradient lithiophilic structure. Because the spherical Li greatly reduces the interfacial side reactions and avoids the formation of dead Li, the Li anode affords a high plating/stripping efficiency. Furthermore, the gradient lithiophilic design results in a bottom‐up growth of the spherical Li within the host, safely away from the separator. Thus, the spherical Li anode realizes a long life of >3000 h with a high Li‐utilization rate of >90%, stable cycling in full cells at an areal capacity up to 5 mAh cm−2 with a low negative/positive ratio of 0.8, which is critical for high energy density. Such spherical deposition highlights the critical role of the morphological control of alkali metals and provides a viable method to build practical high‐energy metal batteries.
Artificial Spider Silk with Buckled Sheath by Nano‐Pulley Combing
Authors: Sun Jinkun , Guo Wenjin , Mei Guangkai , Wang Songli , Wen Kai , Wang Meilin , Feng Danyang , Qian Dong , Zhu Meifang , Zhou Xiang , Liu Zunfeng 
Published: June 2023

AbstractThe axial orientation of molecular chains always results in an increase in fiber strength and a decrease in toughness. Here, taking inspiration from the skin structure, artificial spider silk with a buckled sheath–core structure is developed, with mechanical strength and toughness reaching 1.61 GPa and 466 MJ m−3, respectively, exceeding those of Caerostris darwini silk. The buckled structure is achieved by nano‐pulley combing of polyrotaxane hydrogel fibers through cyclic stretch–release training, which exhibits axial alignment of the polymer chains in the fiber core and buckling in the fiber sheath. The artificial spider silk also exhibits excellent supercontraction behavior, achieving a work capacity of 1.89 kJ kg−1, and an actuation stroke of 82%. This work provides a new strategy for designing high‐performance and intelligent fiber materials.
Exploring the Potential of Three‐Dimensional DNA Crystals in Nanotechnology: Design, Optimization, and Applications
Authors: Kong Huating , Sun Bo , Yu Feng , Wang Qisheng , Xia Kai , Jiang Dawei 
Published: June 2023

AbstractDNA has been used as a robust material for the building of a variety of nanoscale structures and devices owing to its unique properties. Structural DNA nanotechnology has reported a wide range of applications including computing, photonics, synthetic biology, biosensing, bioimaging, and therapeutic delivery, among others. Nevertheless, the foundational goal of structural DNA nanotechnology is exploiting DNA molecules to build three‐dimensional crystals as periodic molecular scaffolds to precisely align, obtain, or collect desired guest molecules. Over the past 30 years, a series of 3D DNA crystals have been rationally designed and developed. This review aims to showcase various 3D DNA crystals, their design, optimization, applications, and the crystallization conditions utilized. Additionally, the history of nucleic acid crystallography and potential future directions for 3D DNA crystals in the era of nanotechnology are discussed.
Preparation and specific adsorption of dual antibacterial BSA surface imprinted GO‐PEI/MXene wrinkled microspheres
Authors: Li Yulong , Lyu Yanting , Yang Zuoting , Wang Ting , Zhang Qiuyu , Zhang Baoliang 
Published: June 2023

AbstractMolecular imprinting technology has gained increasing attention and application in protein adsorption and separation. Bacterial growth on the imprinted material would reduce the adsorption selectivity and shorten the service life. To solve the above problems, carrier materials (GO‐PEI/MXene wrinkled microspheres) with dual antibacterial ability are constructed for the first time. BSA surface imprinted GO‐PEI/MXene (GO‐PEI/MXene@MIPs) are constructed in this study. The large exterior surface area increases the number of imprinting sites, thereby enhancing the adsorption capacity. The adsorption capacity of GO‐PEI/MXene@MIPs reaches 312.63 ± 22 mg/g with an imprinting factor (IF) of 3.15 within 90 min. Meanwhile, GO‐PEI/MXene@MIPs can separate BSA from mixed protein solution and fetal bovine serum (FBS) and only loses 14.1% of saturation adsorption after eight cycles. In addition, antibacterial tests show that the material has excellent broad‐spectrum antibacterial effects, which will significantly extend the service life of the material in real‐world environments.
K‐doped CuO/ZnO with dual active centers of synergism for highly efficient dimethyl carbonate synthesis
Authors: Han Han , Ye Xue , Yao Jie , Gao Xinhua , Yu Jinghao , Guo Lisheng , Li Jie 
Published: June 2023

AbstractThe application of heterogeneous catalysts in dimethyl carbonate (DMC) synthesis from methanol is hindered by low activation efficiency of methanol to methoxy intermediates (CH3O*), which is the key intermediate for DMC generation. Herein, a catalyst of alkali metal K anchored on the CuO/ZnO oxide is rationally designed for offering Lewis acid–base pairs as dual active centers to improve the activation efficiency of methanol. Characterizations of CO2‐TPD, NH3‐TPD, XPS, and DRIFTS revealed that the addition of Lewis base K observably boosted the dissociation of methanol and combined with Lewis acid CuO/ZnO oxide to adsorb the formed CH3O* stably, thus synergistically promoted the transesterification. Finally, the CuO/ZnO‐9%K2O catalyst exhibited the optimal catalytic activity, achieving a high yield of 74.4% with an excellent selectivity of 98.9% for DMC at a low temperature of 90°C. The strategy of constructing Lewis acid–base pairs provides a reference for the design of heterogeneous catalysts.
Identification of brain aging subtypes in multiple brain regions from cognitively normal individuals
Authors: Peng Shouneng , Haure‐Mirande Jean‐Vianney , Wang Minghui , Huffman Derek M , Haroutunian Vahram , Ehrlich Michelle E. , Zhang Bin , Tu Zhidong 
Published: June 2023

AbstractBackgroundAlthough late‐onset Alzheimer’s disease (LOAD) occurs in older individuals (age 65 or older), multiple lines of evidence suggests that the dysregulation of brain functions initiates decades earlier. Through examining multiple large‐scale human brain transcriptomic data, we demonstrated that cognitively normal brain aging from donors in their 40s‐60s can group into several subtypes based on their hippocampal transcriptomes. One subtype represents healthy brain aging and some evidence suggests these donors may remain cognitively normal in much older ages, while some brain aging subtypes showed gene expression changes highly similar to those observed in AD, supporting molecular changes linked to AD have occurred much earlier than the manifestation of cognitive impairment. However, whether the brain aging subtype is a common phenomenon across multiple brain regions or very specific to the hippocampus remains unknown.MethodWe compiled and studied transcriptomic data in another commonly studied human brain region (prefrontal cortex) from donors who were cognitively normal. We performed hierarchical clustering in these samples to infer subtypes, differential gene expression analysis was done between samples from different subtypes. We annotated and compared these DEGs with other AD gene expression signatures.ResultWe discovered that aging subtypes could also be observed in the prefrontal cortical region. Similarly to the hippocampus, the differentially expressed genes among aging subtypes also highly overlapped with AD gene signatures. By comparing aging subtypes defined from hippocampal vs. cortical transcriptomes from the same individuals, we found that an AD similar hippocampal sample does not necessarily correspond to AD similar cortical sample in the same donor, suggesting the brain regional complexity of the disease.ConclusionOur analysis of the transcriptomic data from multiple brain regions from cognitively normal individual supports that gene regulation changes related to AD occurs decades earlier than the manifestation of clinical phenotype. Understanding the molecular changes in these early changes in multiple brain regions could be critical to gain new insights into the mechanisms of AD initiation.
Novel c.2654+1G>A mutation in the CSF1R gene in a family with CSF1R‐microglial encephalopathy
Authors: Jiang Jiwei , Xu Jun 
Published: June 2023

AbstractBackgroundThe colony‐stimulating factor‐1 receptor (CSF1R) is a transmembrane tyrosine kinase receptor that is mainly expressed in the brain‐resident microglia. Thus, microglial dysfunction due to CSF1R mutation may play a primary and pivotal role in the pathogenesis of CSF1R‐microglial encephalopathy. Neither the functional consequences of all known CSF1R mutations nor the full genetic spectrum of mutations causing CSF1R‐microglial encephalopathy have been fully elucidated. We aimed to describe a novel heterozygous splicing variant of the CSF1R gene that caused CSF1R‐microglial encephalopathy in a Han Chinese family.MethodThe demographic data, detailed medical history, and clinical manifestations were collected from a family with CSF1R‐microglial encephalopathy. Some family members also underwent neuropsychological evaluation, structural and functional magnetic resonance imaging (MRI), and whole‐exome sequence analyses.ResultFour generations of this family, including 27 members, presented with a medical history of a dominant hereditary pattern (Figure 1). Seven of these 27 individuals had died, while five presented with similar cognitive impairments clinically, including the proband, and his sister, father, uncle, and grandmother during their life. Brain MRI of the proband (Figure 2) and his sister (Figure 3) depicted symmetric confluent and diffuse deep white matter changes, atrophy of the frontoparietal lobes, and thinning of the corpus callosum. The brother of the proband remained asymptomatic, and the structural brain MRI only revealed minimal white matter changes; however, pseudo‐continuous arterial spin labeling (pCASL) demonstrated marked reduction in the cerebral blood flow (CBF) in the bilateral deep white matter and corpus callosum (Figure 4). Whole‐exome sequencing was performed for seven family members, which identified a novel splice‐site heterozygous mutation (c.2319+1C>A) in intron 20 of the CSF1R gene in four members (Figure 5).ConclusionWe identified a novel splicing mutation (c.2319+1C>A) in intron 20 of CSF1R as the cause of CSF1R‐microglial encephalopathy in a Han Chinese family, which broadens the genetic spectrum of CSF1R‐microglial encephalopathy. We opine that clinically feasible pCASL techniques may be more sensitive to the alterations in CBF of associated with microglial density and cellular changes. This study highlights the potential value of pCASL techniques to improve the clinical diagnostic accuracy of CSF1R‐microglial encephalopathy.
Neuropsychiatric syndromes in Alzheimer’s disease: Systematic review and meta‐analysis of the factor structure of the neuropsychiatric inventory
Authors: Hiu Shaun , Bigirumurame Theophile , Kunonga Patience , Bryant Andrew , Pillai Manjunadh 
Published: June 2023

AbstractBackgroundNeuropsychiatric symptoms (NPS) are a prevalent feature in patients with Alzheimer’s disease (AD). Studies have consistently observed that certain NPS have a tendency to co‐occur with others. One major focus of NPS research has been to understand the factor structure of the Neuropsychiatric Inventory (NPI) to identify neuropsychiatric syndromes in AD. Whilst there is a large literature of studies, there exists heterogeneity in the results derived.MethodWe sought to increase our certainty about how neuropsychiatric syndromes in AD may be defined by conducting a systematic review and meta‐analysis of the literature from 1994‐2020 regarding the factor structure of the NPI. We used meta‐analytic structural equation modelling (MASEM) to pool effect sizes (correlation coefficients between NPI items) under a random effects model and fitted measurement models from published studies to identify a best‐fitting factor structure.ResultTwenty‐four studies met our eligibility criteria however effect sizes were only available for seven studies. For the NPI‐10 (7 studies, n = 5185), a five‐factor structure was found to have good fit to the data across a majority of model fit indices (CFI = 0.966; TLI = 0.940; SRMR 0.031; RMSEA 0.026 [95% CI 0.021, 0.030]). For the NPI‐12 (4 studies, n = 2397), we were unable to identify a factor structure that displayed good model fit.ConclusionOur meta‐analysis indicated that a five‐factor structure to the NPI‐10 – agitation, irritability, and aberrant motor behaviour (factor 1); delusions and hallucinations (factor 2); depression and anxiety (factor 3); euphoria and disinhibition (factor 4); and apathy (factor 5) – was the best‐fitting measurement model.
Study of the mechanism of action of Blarcamesine (ANAVEX®2‐73): Whole blood transcriptomics analysis identifies treatment impact on compensatory pathways by restoring key neurodegenerative pathways functionality, including Alzheimer’s disease pathway
Authors: Williams Coralie , Kindermans Martin , Parmentier Frédéric , Goodsaid Federico , Hammond Edward , Missling Christopher U , Afshar Mohammad 
Published: June 2023

AbstractBackgroundBlarcamesine (ANAVEX®2‐73), a novel oral selective sigma‐1 receptor (SIGMAR1) agonist was investigated in a clinical Phase 2a study in Alzheimer’s disease in which blarcamesine resulted in a lower rate of cognitive (MMSE) and functional (ADCS‐ADL) decline. Following the positive results of this study, a translational approach led to investigating blarcamesine in an international, double‐blind, multicenter, placebo‐controlled Phase 2 clinical study of 14‐week duration in 132 patients with Parkinson’s disease dementia (PDD). Whole blood transcriptomics analysis (RNAseq) was performed for the PDD study at two timepoints: baseline and Week 14. After quality control filtering, 14,150 genes were retained for analysis.MethodsWeighted gene correlation network analysis (WGCNA) was used to identify clusters of genes that show a correlated expression change across patients and timepoints. Thus, a data‐driven gene network was generated. Associations between the identified clusters and treatment arms were explored in order to select clusters for which gene expression is significantly associated with the high blarcamesine dose. These associations were assessed using linear mixed effect models with three covariates: dose, patient and timepoint. Significance was assessed with Dunett’s test.ResultsBlarcamesine significantly restores functionality in key pathways of Alzheimer’s disease, Parkinson’s disease and Prion diseases. The analysis identified two clusters of genes that are significantly differentially expressed in treated patients and represent compensatory pathways to genes dysregulations induced by neurodegenerative diseases. In both clusters, majority of genes were confirmed to interact (STRING database). Amongst interacting genes, neurodegenerative pathways were identified as overrepresented (p < 0.01). Down‐regulation of genes involved with neurodegeneration was observed in the placebo arm, however, was compensated in the blarcamesine arm.ConclusionsThis analysis identified a gene network that is differentially expressed in patients treated with blarcamesine after 14 weeks of treatment, compared to placebo. The biological relevance of this gene network was assessed. Pathway analysis confirmed the impact of the treatment on pathways involved in neurodegenerative diseases The identification of a gene network as the blarcamesine response pathway lays the foundation to better understand the mechanism of action at the molecular level of blarcamesine, thus unlocking characterization of responders based on molecular profiling, as well as identification of new indications in the area of neurodegenerative and other disorders.
Social networks of neighbourhood inhabitants, residents of a care facility, and the nursing staff: a case study in two LTF facilities in the Netherlands
Authors: van Beek Sandra , Groenewegen Peter , Portegijs Suzanne , Huygens Martine , Volker Beate 
Published: June 2023

AbstractBackgroundSocial resources have the potential to relieve the pressure on long‐term care facilities due to population ageing and staff shortages. This is because social networks can constitute the link between residents, staff members of LTC facilities and members of the local community. In this paper we describe these social networks and the relationships of which they consist in two LTC facilities that provide dementia care in the Netherlands, thereby illustrating the social capital of both facilities.MethodsStaff members of the dementia ward in two LTC facilities, family members of residents and inhabitants of the neighbourhoods surrounding the LTC facilities were asked to complete questionnaires.ResultsThere are direct and indirect relationships between nursing staff, family members of residents and inhabitants of the neighbourhood. Staff know residents both directly, and indirectly through connections with other persons in the community. There is regular contact between staff members and family members of residents during visits of family members; one third of nursing staff also talk to family members outside the LTC facility. Furthermore, staff members often live close to the facility and are therefore connected to inhabitants of the neighbourhood. About half of the neighbourhood inhabitants visited the LTC facility during the past 12 months for various reasons. More than half of the neighbourhood inhabitants know persons that work in the LTC facility, one in five knows a staff member working on the dementia ward. In total, 8% of the neighbourhood inhabitants in our study worked as a volunteer in the LTC facilities.ConclusionThe network of the LTC facilities’ staff, residents with dementia, and local community consists of many direct and indirect relationships. Although it is difficult for residents with dementia to uphold their social networks, there are numerous ties that demonstrate the pre‐existing social relationships of persons with dementia in the community that can be employed to provide person‐centred care. The embeddedness of LTC facilities can also be considered as a resource in finding and retaining personnel and volunteers, as most of the staff live in the neighbourhood and volunteers are often in close proximity.