bluuebunny/crossref_metadata_2025_split huggingface dataset:
The hypertension and hyperlipidemia status among type 2 diabetic patients in the community and influencing factors analysis of glycemic control
Authors: Zhai Zhiyu , Yang Yunou , Lin Guozhen , Lin Weiquan , Wu Jiagang , Liu Xiangyi , Zhang Shijia , Zhou Qin , Liu Hui , Hao Guang 
Published: April 2023

Abstract
Objective
To understand the prevalence of hypertension and hyperlipidaemia as well as the current status of glycaemic control and its influencing factors among type 2 diabetes mellitus patients in the community in South China, and to provide recommendations for the prevention and control of diabetes.

Methods
Questionnaires, physical examinations and laboratory tests were conducted on patients with type 2 diabetes mellitus who participated in the National Basic Public Health Service Programme in Guangzhou in 2020. The chi-square test, t-test and multi-factor unconditional logistic regression analysis were performed using R 4.1.2 software.

Result
Among 127,423 type 2 diabetic patients in Guangzhou, 57,695 achieved glycemic control standards, with a glycemic control rate of 45.28%.In this study, the proportion of T2DM patients with hypertension and hyperlipidaemia together was 27.79%, The percentage of T2DM patients with hypertension alone and hyperlipidaemia alone was 28.34% and 20.53% respectively, and the rate of no complications was 23.34%. There was a statistically significant difference in the rate of glycaemic control between the different disease combination states (P < 0.05). The glycaemic control rate was 47.67% in diabetic patients without hypertension and hyperlipidaemia, 52.54% and 37.24% in those with combined hypertension alone and hyperlipidaemia alone respectively, compared to 41.80% in diabetic patients with hypertension and hyperlipidaemia. After adjusting for all covariates, multivariate analysis showed that combined hypertension alone was associated with good glycaemic control (OR 0.817, 95% CI 0.791, 0.843, P < 0.001),when using comorbid T2DM as a control group, combined hyperlipidaemia alone, combined hypertension and hyperlipidaemia were associated with poor glycaemic control (OR 1.521, 95% CI 1.470,1.574, P < 0.001 and OR 1.250, 95% CI 1.211,1.291, P < 0.001), Subgroup analyses as well as multifactorial unconditional logistic regression analyses showed that patients with type 2 diabetes who were overweight and obese, smoked, drank alcohol, had a diagnosis of diabetes for ≥ 6 years, had fair or poor adherence and had a family history of diabetes had lower rates of glycaemic control.

Conclusion
The results of this study showed that the co-morbidity of hypertension and hyperlipidaemia was high and prevalent among diabetic patients in Guangzhou. Moreover, glycaemic control of T2DM patients with hyperlipidaemia was lower than other diabetic patients. Obesity and overweight, poor lifestyle and dietary habits are also major factors affecting the treatment and control of T2D patients in this region. Therefore, comprehensive measures should be actively taken to control blood glucose levels in type 2 diabetic patients by also incorporating lipid management into the community and strictly controlling lipid levels.
Time to surgery and myo-d expression in biceps muscle of adult brachial plexus injury: a preliminary study
Authors: Suroto Heri , Wardana Gestana Retaha , Sugianto Julius Albert , Aprilya Dina , Samijo Steven 
Published: April 2023

Abstract
Background
Brachial Plexus Injury (BPI) is one of the peripheral nerve injuries which causes severe functional impairment and disability. Without prompt treatment, prolonged denervation will cause severe muscle atrophy. MyoD, which is expressed by satellite cells, is one of the parameters that relate to the regeneration process in post-injury muscle and it is presumed to determine the clinical outcome following neurotization procedure. This study aims to understand the correlation between time to surgery (TTS) and MyoD expression in satellite cells in the biceps muscle of adult brachial plexus injury patients.

Methods
Analytic observational study with a cross-sectional design was conducted at Dr. Soetomo General Hospital. All patients with BPI who underwent surgery between May 2013 and December 2015 were included. Muscle biopsy was taken and stained using immunohistochemistry for MyoD expression. Pearson correlation test was used to assess the correlation between MyoD expression with TTS and with age.

Results
Twenty-two biceps muscle samples were examined. Most patients are males (81.8%) with an average age of 25.5 years. MyoD expression was found to be highest at TTS of 4 months and then dropped significantly (and plateau) from 9 to 36 months. MyoD expression is significantly correlated with TTS (r=-0.895; p = 0.00) but not with age (r=-0.294; p = 0.184).

Conclusion
Our study found, from the cellular point of view, that treatment of BPI needs to be done as early as possible before the regenerative potential - as indicated by MyoD expression – declined.
Association between high cardiac output at altitude and acute mountain sickness: preliminary study on Mt. Fuji
Authors: Ebihara Takeshi , Shimizu Kentaro , Mitsuyama Yumi , Ogura Hiroshi , Oda Jun 
Published: April 2023

Abstract
Background
Acute mountain sickness (AMS) affects around 30% of people climbing Mt. Fuji, but its pathogenesis is incompletely understood. The influence of a rapid ascent to high altitude by climbing and summiting Mt. Fuji on cardiac function in the general population is unknown, and its association with altitude sickness has not been clarified.

Methods
Subjects climbing Mt. Fuji were included. Heart rate, oxygen saturation, systolic blood pressure, cardiac index (CI) and stroke volume index were measured multiple times at 120 m as baseline values and at Mt. Fuji Research Station (MFRS) at 3,775 m. Each value and its difference from the baseline value (Δ) of subjects with AMS (defined as Lake Louise Score [LLS] ≥ 3 with headache after sleeping at 3,775 m) were compared with those of non-AMS subjects.

Results
Eleven volunteers who climbed from 2,380 m to MFRS within 8 h and stayed overnight at MFRS were included. Four suffered AMS. Compared with the non-AMS subjects, CI in the AMS subjects was significantly higher than that before sleeping (median [interquartile range]: 4.9 [4.5, 5.0] vs. 3.8 [3.4, 3.9] mL/min/m2; p = 0.04), and their ΔCI was significantly higher before sleeping (1.6 [1.4, 2.1] vs. 0.2 [0.0, 0.7] mL/min/m2; p < 0.01) and after sleeping (0.7 [0.3, 1.7] vs. -0.2 [-0.5, 0.0] mL/min/m2; p < 0.01). ΔCI in the AMS subjects dropped significantly after sleeping versus before sleeping (3.8 [3.6, 4.5] vs. 4.9 [4.5, 5.0] mL/min/m2; p = 0.04).

Conclusions
Higher values of CI and ΔCI were observed at high altitude in the AMS subjects. A high cardiac output might be associated with the development of AMS.
Correlates of quality of life and mental health among youth experiencing homelessness in Iran
Authors: Malekmohammadi Neda , Mehmandoost Soheil , Khezri Mehrdad , Mirzaei Hossein , Tavakoli Fatemeh , Mousavian Ghazal , Safizadeh Mansureh , Iranpour Abedin , Sharifi Hamid 
Published: April 2023

Abstract
Background
Quality of life (QOL) and mental health among marginalized populations, including people experiencing homelessness in Iran, are understudied. We assessed the QOL and mental health status as well as their associated factors among youth experiencing homelessness in Kerman, Iran.

Method
We recruited 202 participants using a convenience sampling method from 11 locations, including six homeless shelters, three street outreach sites, and two drop-in service centers, from September to December 2017. Data were collected using a standardized questionnaire that included QOL, mental health, demographics, drug use, and sexual behaviors questions. Scores in each domain were indexed with a weight of 0-100. The higher score indicated a higher QOL and mental health status. Bivariable and multivariable linear regression models were performed to examine correlates of QOL and mental health.

Result
The mean (SD) score of QOL and mental health were 73.1 (25.8) and 65.1 (22.3), respectively. Multivariable analysis showed that youth experiencing homelessness who were aged 25–29 years old (β = -5.4; 95% CI: -10.51; -0.30), and lived on the streets (β = -12.1; 95% CI: -18.19; -6.07) had a lower mental health score. Moreover, those who had higher education (β = 5.4; 95% CI: 0.58; 10.38), had no history of carrying weapons (β = 12.8; 95% CI: 6.86; 18.76), and had a higher QOL score (β = 0.41; 95% CI: 0.31; 0.50) had a higher mental health score.

Conclusion
This study highlights that QOL and mental health among youth experiencing homelessness in Iran are concerning, particularly among those who were older, were less educated, were living on the street, and had a history of carrying a weapon. Community-based programs, including mental health care and affordable housing are needed to improve QOL and mental health among this population in Iran.
LncRNA AC006064.4–201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1
Authors: Shen Panyang , Gao Jun , Huang Shaohan , You Chenan , Wang Haitao , Chen Pengyu , Yao Teng , Gao Tianyou , Zhou Bohao , Shen Shuying , Zhao Xing , Ma Jianjun 
Published: April 2023

Abstract
Background
Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA development. However, the intrinsic mechanism of chondrocyte senescence is still unclear. This study aimed to investigate the role of a novel long non-coding RNA (lncRNA), AC006064.4–201 in the regulation of chondrocyte senescence and OA progression and to elucidate the underlying molecular mechanisms.

Methods
The function of AC006064.4–201 in chondrocytes was assessed using western blotting, quantitative real-time polymerase chain reaction (qRT-PCR), immunofluorescence (IF) and β-galactosidase staining. The interaction between AC006064.4–201 and polypyrimidine tract-binding protein 1 (PTBP1), as well as cyclin-dependent kinase inhibitor 1B (CDKN1B), was evaluated using RPD-MS, fluorescence in situ hybridization (FISH), RNA immunoprecipitation (RIP) and RNA pull-down assays. Mice models were used to investigate the role of AC006064.4–201 in post-traumatic and age-related OA in vivo.

Results
Our research revealed that AC006064.4–201 was downregulated in senescent and degenerated human cartilage, which could alleviate senescence and regulate metabolism in chondrocytes. Mechanically, AC006064.4–201 directly interacts with PTBP1 and blocks the binding between PTBP1 and CDKN1B mRNA, thereby destabilizing CDKN1B mRNA and decreasing the translation of CDKN1B. The in vivo experiments were consistent with the results of the in vitro experiments.

Conclusions
The AC006064.4–201/PTBP1/CDKN1B axis plays an important role in OA development and provides new molecular markers for the early diagnosis and treatment of OA in the future.

Graphical Abstract
Schematic diagram of AC006064.4–201 mechanism. A schematic diagram of the mechanism underlying the effect of AC006064.4–201
Factors associated with discharge destination from acute care after moderate-to-severe traumatic injuries in Norway: a prospective population-based study
Authors: Moksnes Håkon Øgreid , Schäfer Christoph , Rasmussen Mari Storli , Søberg Helene Lundgaard , Røise Olav , Anke Audny , Røe Cecilie , Næss Pål Aksel , Gaarder Christine , Helseth Eirik , Dahl Hilde Margrete , Hestnes Morten , Brunborg Cathrine , Andelic Nada , Hellstrøm Torgeir 
Published: April 2023

Abstract
Background
Previous studies have demonstrated that the trauma population has needs for rehabilitation services that are best provided in a continuous and coordinated way. The discharge destination after acute care is the second step to ensuring quality of care. There is a lack of knowledge regarding the factors associated with the discharge destination for the overall trauma population. This paper aims to identify sociodemographic, geographical, and injury-related factors associated with discharge destination following acute care at trauma centers for patients with moderate-to-severe traumatic injuries.

Methods
A multicenter, population-based, prospective study was conducted with patients of all ages with traumatic injury [New Injury Severity Score (NISS) > 9] admitted within 72 h after the injury to regional trauma centers in southeastern and northern Norway over a 1-year period (2020).

Results
In total, 601 patients were included; a majority (76%) sustained severe injuries, and 22% were discharged directly to specialized rehabilitation. Children were primarily discharged home, and most of the patients ≥ 65 years to their local hospital. Depending on the centrality of their residence [Norwegian Centrality Index (NCI) 1–6, where 1 is most central], we found that patients residing in NCI 3–4 and 5–6 areas sustained more severe injuries than patients residing in NCI 1–2 areas. An increase in the NISS, number of injuries, or a spinal injury with an Abbreviated Injury Scale (AIS) ≥ 3 was associated with discharge to local hospitals and specialized rehabilitation than to home. Patients with an AIS ≥ 3 head injury (RRR 6.1, 95% Confidence interval 2.80–13.38) were significantly more likely to be discharged to specialized rehabilitation than patients with a less severe head injury. Age < 18 years was negatively associated with discharge to a local hospital, while NCI 3–4, preinjury comorbidity, and increased severity of injuries in the lower extremities were positively associated.

Conclusions
Two-thirds of the patients sustained severe traumatic injury, and 22% were discharged directly to specialized rehabilitation. Age, centrality of the residence, preinjury comorbidity, injury severity, length of hospital stay, and the number and specific types of injuries were factors that had the greatest influence on discharge destination.
Co-designing and pilot testing an infographic to support patients/families through the REMAP-CAP consent process: a mixed-methods study protocol
Authors: O’Grady Heather K. , Bhimani Zahra , Dalziel Sandra , Dolanjski Barbara , Sandhu Gyan , Santos Marlene , Smith Kathy , Murthy Srinivas , Marshall John C. , Kho Michelle E. 
Published: April 2023

Abstract
Background
Informed consent is critical to the ethical conduct of clinical research and requires understanding of a trial including its purpose, process, potential risks and benefits, and alternatives to participation. This can be challenging for complex trials, such as platform trials, and in high-stress environments, such as the intensive care unit (ICU). REMAP-CAP (randomized, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia) is a platform trial which studies treatments for ICU patients with community-acquired pneumonia, including COVID-19. Patient/family partners (PFP) identified challenges during the REMAP-CAP consent process.

Methods
This is a patient-centred co-design study to refine and test an infographic to supplement current REMAP-CAP consent documents. Infographic prototypes were developed by patients, substitute decision-makers (SDMs), and researchers with lived experience in the ICU or with ICU research. We will apply a two-phase exploratory sequential, mixed-methods research design. In phase 1, we will conduct focus groups with ICU patients, SDMs, and research coordinators (RCs). We will use inductive content analysis to inform infographic refinement, to be pilot tested in phase 2. Phase 2 is a prospective study within a trial (SWAT) at ≤ 5 REMAP-CAP sites. We will collect self-reported data from patients/SDMs and RCs. The primary outcome is feasibility (eligible consent encounters, receipt of infographic, consent to follow-up, completion of follow-up surveys). Data will be integrated to understand if/how quantitative results build upon the qualitatively informed infographic.

Discussion
Phase 1 results will be used to co-design an infographic, directly informed by the perspectives of patients, SDMs, and RCs involved in ICU research consent discussions. Results from phase 2 will determine the feasibility of infographic implementation in REMAP-CAP consent encounters. These feasibility data will inform a larger SWAT to evaluate our consent infographic. If successful, use of a co-designed infographic to support REMAP-CAP consent documents may improve the experience of consent for patients, SDMs, and RCs.

Trial registration
The Northern Ireland Hub for Trials Methodology Research SWAT Repository (SWAT no. 176)
Responsiveness of the patient-specific Canadian occupational performance measure and a fixed-items activity limitations measure in patients with dupuytren disease
Authors: Lauritzson Anna , Eckerdal David , Atroshi Isam 
Published: April 2023

Abstract
Background
Patients with Dupuytren disease experience various activity limitations. Treatment aims to reduce finger joint contractures to improve hand function and activity performance. For assessing improvement different patient-centered measures have been used. The Canadian Occupational Performance Measure (COPM) was developed as an interview-based outcome measure to detect changes over time in patients’ perception of their performance and satisfaction in self-identified activity issues. The 11-item disabilities of the arm, shoulder and hand (QuickDASH) scale consists of fixed items that ask patients to rate the difficulty in performing specific daily activities. Few studies have compared the responsiveness of these two types of patient-reported measures in Dupuytren disease.

Patients and methods
We included 30 patients with Dupuytren disease enrolled in a prospective cohort study of collagenase injection. We used the COPM (score range 1–10), the QuickDASH (score range 0-100) and measurement of finger joint contracture before and 5 weeks after treatment.

Results
Using the COPM the patients identified 107 activity problems (55 in self-care, 19 in productivity and 33 in leisure). The two most common activity problems were to wash self (21 patients) and to don gloves (19 patients). A clinically important improvement with 3 points or greater from baseline to 5 weeks was seen for performance in 77 activities (72%). The median COPM performance score improved from 4.4 at baseline to 9.0 at 5 weeks and the median QuickDASH score improved from 13.6 to 2.5. Responsiveness (Cohen’s d) for the COPM performance was 2.6 (95% CI 1.9–3.3) and for the QuickDASH 0.6 (95% CI 0.1–1.1).

Conclusion
The COPM had about 4-fold larger responsiveness than the QuickDASH, which supports use of an individualized measure when assessing treatment effects in Dupuytren disease.
Regenerative medicine owes to microsurgery
Authors: Shirbache Kamran , Nematian Hossein , Nabian Mohammad Hossein 
Published: April 2023

AbstractNew findings in regenerative medicine have always been combined with numerous animal studies. Therefore, choosing the right translational animal model plays an important role in transferring as much basic knowledge as possible to clinical application in this field. Since microsurgery has many capabilities to perform precise interventions on small animal models and facilitates other regenerative medicine procedures, based on scientific articles, we believe that the key to the flourishing of regenerative medicine in the clinic is the use of microsurgery.
PRODUÇÃO CIENTÍFICA SOBRE A CRIAÇÃO DE VALOR PÚBLICO: UM ESTUDO BIBLIOMÉTRICO NA BASE WEB OF SCIENCE (1998-2021)
Authors: Bonifácio Guilherme Henrique Pires , Costa Luana Aparecida da , Santos Lucas Maia dos 
Published: April 2023

A criação de valor público pode ser compreendida como uma filosofia de gestão e uma estrutura de processos para se alcançar valores pretendidos; no contexto de administração pública, contempla as dimensões da capacidade operacional, do ambiente autorizador e de resultados sociais almejados. A presente pesquisa objetivou analisar como se configura o campo de pesquisas sobre esse tema, abordando perspectivas de tal campo por meio da exposição dos principais autores e trabalhos publicados. Foi realizado estudo bibliométrico e levantamento quantitativo descritivo, utilizando-se da plataforma Web of Science da Thomson Reuters. Os resultados demonstram que a base intelectual do campo versa sobre assuntos como prestação eficiente de serviços pelo governo, participação da sociedade, cultura organizacional avaliativa e percepções individuais no que tange a características emocionais do processo. A frente de pesquisas do campo versa sobre questões como análises sobre as práticas de gestão pública, ações de governança e estruturação de processos.
Perceptions of professional nurses towards the inclusion of spiritual activities in oncology practice in the uMgungundlovu and eThekwini Health Districts, KwaZulu-Natal, South Africa: A quantitative descriptive study.
Authors: Sewkarran Vashni , Gumede Emelda Zandile 
Published: April 2023

Background: Internationally the inclusion of spiritual activities has been well adopted into nursing care. Spiritual activities could be used as one of the coping strategies for cancer patients in times of emotional distress. The South African perspective highlights a huge gap regarding incorporating spiritual activities into oncology practice. Due to popularity and frequent use, the need for identifying the perceptions of professional nurse’s regarding the inclusion of spiritual activities in oncology nursing practice was vital. Methods: The study followed a quantitative descriptive survey. Four health care institutions were purposively selected in the eThekwini and uMgungundlovu health district. Simple random selection of 89 participants that met the eligibility criteria was conducted. Self-administered questionnaires were used to collect data over a period of four weeks from 3rd January 2022 to 9th February 2022, followed by analysis using the SPSS, version 27. Results: The findings revealed that professional nurses agree that spiritual care can be provided by including various spiritual activities into oncology nursing practice. More than 80% of professional nurses believed in God. Activities like arranging visits by chaplains, showing kindness, cheerfulness, and reassurance were highly rated, exceeding 80%; however, activities like art and creativity were poorly rated, 32.6%. These findings are in line with the hypothesis of the researcher. Conclusion: This study produced empirical evidence that spiritual care can be provided by including various spiritual activities in oncology practice to promote comprehensive nursing care. A module on spirituality should be included in the new oncology program to boost the nurse’s levels of confidence in spiritual care. The study will enhance the nurses’ awareness and expertise in providing a range of activities.