bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life-Cycle Greenhouse Gas Emissions from Forest Bioenergy Production at Combined Heat and Power Projects in Nova Scotia, Canada
Authors: Steenberg James W N , Laganière Jérôme , Ayer Nathan W , Duinker Peter N 
Published: January 2023

Abstract
Forest bioenergy production can represent a renewable energy supply while benefiting the forest sector. However, greenhouse gas (GHG) reductions are often not immediate. The point of carbon parity where bioenergy starts delivering GHG benefits may be years to decades in the future. This study examined the life-cycle emissions associated with bioenergy production at combined heat-and-power (CHP) projects in Nova Scotia, Canada. We examined the effects and sensitivities of different feedstock mixes of chips from harvested roundwood and mill residues, the implementation of intensive and extensive silviculture strategies, and different market/supply-chain assumptions around additionality and product substitution. We found contrasting GHG outcomes for bioenergy, depending largely on additionality assumptions and biomass type. When primary biomass (roundwood) was used as the feedstock type, carbon parity was achieved within four to nine years when pulp and paper products were substituted, whereas carbon parity was achieved in 86–100 years or longer when biomass harvests were additional. Net GHG benefits were achieved in 10 years with the use of secondary biomass (mill residues) as the bioenergy feedstock, although they were delayed when at lower energy conversion efficiencies. Adoption of more intensive silvicultural practices (plantations) reduced the time to carbon parity because of increased yields, although uncertainties in long-term soil carbon storage exist.
Study Implications: Our analysis shows that the use of forest biomass in local CHP facilities can deliver GHG benefits in the short term but there is substantial variability. Carbon parity times were the longest with the use of additional primary biomass feedstocks (i.e., roundwood) but were substantially reduced when biomass harvests substituted harvests for pulp and paper products and when secondary biomass (i.e., mill residues) was used. This study highlights the nuance of different forest management dimensions (e.g., silviculture) while also presenting novel findings on the importance of assumptions around biomass harvesting being additional to current practices or a substitution for declines in traditional forest products.
Pronunciations of Combining Forms and Affixes in the Oxford English Dictionary
Authors: Moreland Matthew , Sangster Catherine 
Published: January 2023

Abstract
The third edition of the Oxford English Dictionary (OED3) incorporates a new approach to the pronunciation sections of combining form and affix entries. Headword-level pronunciations are replaced by statements pertaining to typical stress patterns and vowel reduction, while thousands of lemmas contained within these entries receive British and American pronunciations for the first time. Accounting for the four different structures of current OED combining form and affix entries, the integration of pronunciation information is tailored to supply the user with an appropriate and useful level of information in each case.
The 2022 International Society for Hip Preservation (ISHA) physiotherapy agreement on assessment and treatment of greater trochanteric pain syndrome (GTPS): an international consensus statement
Authors: Disantis Ashley , Andrade Antonio J , Baillou Alexander , Bonin Nicolas , Byrd Thomas , Campbell Ashley , Domb Benjamin , Doyle Holly , Enseki Keelan , Getz Barry , Gosling Lucie , Grant Louise , M. Ilizaliturri Jr. Victor , Kohlrieser Dave , Laskovski Jovan , Lifshitz Liran , P. McGovern Ryan , Monnington Katie , O’Donnell John , Takla Amir , Tyler Tim , Voight Mike , Wuerz Thomas , Martin RobRoy L 
Published: January 2023

ABSTRACT
The 2022 International Society of Hip Preservation (ISHA) physiotherapy agreement on assessment and treatment of greater trochanteric pain syndrome (GTPS) was intended to present a physiotherapy consensus on the assessment and surgical and non-surgical physiotherapy management of patients with GTPS. The panel consisted of 15 physiotherapists and eight orthopaedic surgeons. Currently, there is a lack of high-quality literature supporting non-operative and operative physiotherapy management. Therefore, a group of physiotherapists who specialize in the treatment of non-arthritic hip pathology created this consensus statement regarding physiotherapy management of GTPS. The consensus was conducted using a modified Delphi technique to guide physiotherapy-related decisions according to the current knowledge and expertise regarding the following: (i) evaluation of GTPS, (ii) non-surgical physiotherapy management, (iii) use of corticosteroids and orthobiologics and (iv) surgical indications and post-operative physiotherapy management.
MYB/MYBL1::QKI fusion-positive diffuse glioma
Authors: Suh Ye Yoon , Lee Kwanghoon , Shim Yu-Mi , Phi Ji Hoon , Park Chul-Kee , Kim Seung-Ki , Choi Seung Hong , Yun Hongseok , Park Sung-Hye 
Published: January 2023

Abstract
The MYB/MYBL1::QKI fusion induces the protooncogene, MYB, and deletes the tumor suppressor gene, QKI. MYB/MYBL1::QKI rearrangement was previously reported only in angiocentric glioma (AG) and diffuse low-grade glioma. This report compares 2 tumors containing the MYB/MYBL1::QKI fusion: a diffuse pediatric-type high-grade glioma (DPedHGG) in an 11-year-old boy and an AG in a 46-year-old woman. We used immunohistochemistry, next-generation sequencing, and methylation profiling to characterize each tumor and compare our findings to the literature on AG and tumors with the MYB/MYBL1::QKI rearrangement. Both tumors were astrocytic with angiocentric patterns. The MYB::QKI fusion-positive DPedHGG, which recurred once, was accompanied by TP53 mutation and amplification of CDK6 and KRAS, suggesting malignant transformation secondary to additional genetic aberrations. The second case was the adult AG with MYBL1::QKI fusion, which mimicked ependymoma based on histopathology and its dot- and ring-like epithelial membrane antigen positivity. Combined with a literature review, our results suggest that MYB/MYBL1 alterations are not limited to low-grade gliomas, including AG. AG is most common in the cerebra of children and adolescents but exceptional cases occur in adults and the acquisition of additional genetic mutations may contribute to high-grade glioma. These cases further demonstrate that molecular characteristics, morphologic features, and clinical context are essential for diagnosis.
Beta-Lactam Allergy Association with Surgical Site Infections in Pediatric Procedures: A Matched Cohort Study
Authors: Scaggs Huang Felicia , Mangeot Colleen , Sucharew Heidi , Simon Katherine , Courter Joshua , Risma Kimberly , Schaffzin Joshua K 
Published: January 2023

Abstract

Background
Little is known about surgical site infection (SSI) risk among pediatric patients with reported beta-lactam allergy (BLA).

Methods
We performed a retrospective cohort study at a quaternary children’s hospital and compared procedures in patients ages 1–19 years old with and without BLA that required antimicrobial prophylaxis (AMP) during 2010–2017. Procedures were matched 1:1 by patient age, complex chronic conditions, year of surgery, and National Surgical Quality Improvement Program current procedural terminology category. The primary outcome was SSI as defined by National Healthcare Safety Network. The secondary outcome was AMP protocol compliance as per American Society of Health-System Pharmacists.

Results
Of the 11 878 procedures identified, 1021 (9%) had a reported BLA. There were 35 (1.8%) SSIs in the matched cohort of 1944 procedures with no significant difference in SSI rates in BLA procedures (1.8%) compared to no-BLA (1.9%) procedures. Tier 3 AMP was chosen more frequently among BLA procedures (P &lt; .01). Unmatched analysis of all procedures showed that 23.7% of BLA procedures received beta-lactam-AMP (vs. 93.7% of procedures without BLA). There were no major differences in SSI on sensitivity analysis of BLA procedures that did not receive beta-lactam AMP (1.4%) compared to no-BLA procedures with beta-lactam AMP (1.6%).

Conclusions
Our retrospective matched analysis of 1944 pediatric procedures found no increase in SSIs in procedures with reported BLA, which differs from studies in adults. We observed that the choice of beta-lactam-AMP was common, even in BLA procedures. More data are needed to delineate an association between non-beta-lactam AMP and SSI in children.
Attention and (Painful) Interest: Revisiting the Interest Theory of Attention
Authors: Textor Mark 
Published: January 2023

Abstract
The nineteenth century saw the development of reductive views of attention. The German philosopher and psychologist Carl Stumpf (1848-1936) proposed an original reductive view according to which attention is nothing but interest and interest itself is a positive feeling. Stumpf’s view was developed by Francis Bradley (1846-1924), George Frederick Stout (1860-1944), and Josiah Royce (1855-1916), but has been overlooked in the recent literature. In this paper, I will expound Stumpf’s view of attention, trace it back to its Aristotelian roots and defend the version offered by Stout and Royce. In this version a new kind of feeling, feelings of interest, and value, intellectual value, take centre stage.
Virtual Parent Coaching of Music Interventions for Young Autistic Children in Mexico
Authors: Hernandez-Ruiz Eugenia 
Published: January 2023

Abstract
The coronavirus disease (COVID-19) pandemic disrupted education, peer interactions, and social access for a large percentage of learners and created increased stress and workloads for parents, particularly in families of autistic children, who lost access to specialized services. Providing parents with resources to support their children at home became a necessity. This exploratory study investigated the feasibility of a parent coaching model of music interventions through virtual sessions in a low-resource country. Eight families participated in six 1-hr weekly sessions where the music therapist shared music interventions for young autistic children through videoconferencing. Results show that parent coaching in a virtual setting is feasible, useful, and acceptable for parents. All parents improved in their ability to modify the environment to address child’s needs, adequately respond to their child’s communication attempts, and provide opportunities for engagement and natural reinforcement. Parents found the coaching important, useful, and supportive. Initial recommendations for practice include providing guidelines for safe sessions; adapting to family needs, strengths, and culture; relaying information quickly and concisely; and ensuring that parents can access local services to continue their parenting journey.
IDENTIFICATION OF AREAS OF HIGH POTENTIAL-BEARING MINERALIZATIONS, EASTERN DESERT OF EGYPT: INSIGHTS FROM AIRBORNE GAMMA-RAY SPECTROMETRIC DATA
Authors: Abu Donia Atef M 
Published: January 2023

AbstractA major number of mineral deposits are related to hydrothermal processes. Therefore, the mapping of the hydrothermally alteration areas, connected with mineralization, is crucial in the search for metal deposits. To achieve this purpose, areas of hydrothermal alterations are targeted by processing the airborne gamma-ray spectrometric data to detect areas enriched in potassium that may indicate the existence of potassic alteration zones, which are often associated with hydrothermal alterations accompanied by mineral deposits. Data processing and analysis were performed using the K/eTh ratio, deviation of ideal potassium (Kd) and F-parameter. Besides, determining the environmental radiation risk due to the fact that the study area contains many excavation sites for various mining materials and quarries. Hydrothermal alteration indicator maps show five known mineralizations of gold, copper, molybdenum, fluorite and wolframite, which are associated with hydrothermal processes that took place in the study area. It is possible to note the intimate correlation of mineral deposits present in areas with high potassium content. Positive correlation between the computed hydrothermal alteration indicators (K/eTh, Kd and F-parameter), shown on the ternary image map, revealed favorable high and intermediate targets for the detection of various mineral deposits in the study area. On the other hand, the estimated mean values of absorbed dose rate for all rock units were within the permissible range (28–120 nGy h−1), and the mean annual effective dose rate was below the permissible limit of 1.0 mSv y−1 for these rocks.
Review of the role of MRI and 18F-sodium fluoride PET/computed tomography in the characterisation of spinal bone metastases in a cohort of patients with breast cancer
Authors: Panagiotidis Emmanouil , Pant Vineet , Vinjamuri Sobhan 
Published: January 2023

Purpose
The purpose of the study was to compare the diagnostic accuracy and relative usefulness of MRI and 18F-NaF (sodium fluoride) PET/computed tomography (CT) for detection of spinal bone metastases in a cohort of patients with high-risk breast cancer (BrCa).

Methods
A retrospective study was conducted of patient and lesion-based analyses on 66 consecutive patients (median age, 62.5 years; age range, 33–91 years) who underwent Spinal MRI as well as 18F-NaF PET-CT for restaging of newly diagnosed recurrent BrCa with no previous bone metastases. Both scans were performed within 20 days of each other. Review of prior images, clinical decisions, multi-disciplinary team discussions and decisions as well as follow-up information including scans and definitive tests was performed at least 12 months after the initial scans.

Results
Of the 66 patients reviewed, 26 patients had documented spinal bone metastases on one or both modalities, while 40 patients were considered bone disease free on both modalities and this was confirmed on follow-up. On lesion-based analysis, the findings of 18F-NaF PET-CT and spinal MRI were concordant in 51 patients (77.3%). In the remaining patients, 18F-NaF PET/CT detected more lesions in 4 patients (7.6%) and MRI detected more lesions in 10 patients (15.1%). Interestingly, there was a very high, 97 % concordance (64 patients) between spinal MRI and 18F-NaF PET-CT when staging of spinal bone metastasis was taken into consideration. In one patient MRI identified two spinal bone metastases which were not seen on 18F-NaF PET/CT; and, in one patient 18F-NaF PET/CT showed few spinal bone metastases when no lesion was seen on MRI.

Conclusions
Our study showed a high level of concordance between 18F NaF PET-CT and spinal MRI within the setting of detection of bone lesions in the spine in a cohort of patients with high-risk BrCa. In our opinion, this high level of concordance negates the need to perform both tests although each test may be indicated for slightly different reasons. Further longitudinal studies across a longer duration and more centres may provide more definitive answers.
State-based policies to promote early childhood health and improve equity
Authors: Scarmo Stephanie , Fresina Lori 
Published: January 2023

Purpose of review
Several states are advancing policies to promote equity and positively impact the health of infants, toddlers, and their families. We review five broad issues areas that states can pursue through policy or dedicated funding.

Recent findings
Policy campaigns to support nutrition security, early childhood education, healthcare access, tobacco cessation, and family income supports will improve the health and wellbeing of young children and their families through short-term and long-term impacts, including improved birth outcomes, social–emotional learning, and chronic disease prevention.

Summary
Clinicians, researchers, advocates, and decision-makers play a crucial role in advancing policies and programs that promote equity and positively impact the health of infants, toddlers, and families. To advance equity, states should strive to center families and communities in policy-change efforts.
Salvage radical prostatectomy
Authors: Nabavizadeh Reza , Karnes R. Jeffrey 
Published: January 2023

Purpose of review
Salvage radical prostatectomy (sRP) is underutilized because of fear of historical high rates of peri-operative morbidities. However, there has been significant improvements in complication rates as well as oncologic outcomes in the recent years.

Recent findings
Complication rates have significantly declined for both open and robotic approach in the past decade. Rectal injury is now reported around 2%, which is down from 30% in the historic series. Similarly, the current risk of major vascular injury is low. About 75% of patients report social continence (up to one pad per day). However, erectile function recovery remains poor and patients should be counselled accordingly. Long-term durable oncologic response is achievable with 10-year recurrence-free survival reported in about 40–50% of well selected patients.

Summary
Recent improvements in oncologic and peri-operative outcomes make sRP a desirable option for local control. sRP treats the whole gland as opposed to focal therapies and allows for pelvic lymph node dissection and removal of seminal vesicles, which can be sanctuary site of disease. In experienced hands, regardless of the surgical approach, sRP can achieve a durable response resulting in delaying or avoiding androgen deprivation therapy and its associated morbidities.
Cryptococcal Meningitis in a Mexican Neurological Center
Authors: Cárdenas Graciela , Vargas-García Luis Felipe , Adames-Espinal Heidy , Soto-Hernández José Luis , Castañón-Olivares Laura Rocío 
Published: January 2023

Background:
Cryptococcal meningitis, one of the most severe infections affecting the central nervous system, often involves severe neurological sequels and high mortality.

Methods:
A retrospective review was performed, including 76 cases admitted in a 10-year period at a neurological referral center in Mexico City. From 68 isolates, 52 fungal specimens were identified as part of the Cryptococcus neoformans var. neoformans complex, 15 as C. neoformans var gattii complex, and one as Cryptococcus non-neoformans/gattii.

Results:
Higher cryptococcal meningitis incidence and severity were found in HIV-infected men; other risk factors frequently observed were diabetes mellitus and labor exposure to poultry. The main clinical manifestations were subacute headache, cognitive alterations, and photophobia (exclusively in HIV patients). MRI was highly sensitive for pathologic findings such as meningeal enhancements and cryptococcomas, most of them associated to C. neoformans complex. Eleven patients developed severe brain vasculitis, as observed by transcranial Doppler. Hydrocephalus with intracranial hypertension was the most frequent complication.

Conclusions:
One-half of the population died, and the rest had neurological sequels, mainly neuropsychiatric manifestations and secondary headaches. These patients developed severe functional limitations in performing daily activities in an independent manner.
Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure
Authors: Altounian Mike , Bellon Anaïs , Mann Fanny 
Published: January 2023

AbstractPrenatal alcohol exposure (PAE) is the leading cause of non-genetic intellectual disabilities in the Western world and is responsible of a wide spectrum of neurodevelopmental disorders referred to as Fetal Alcohol Spectrum Disorders (FASD). Structural and functional deficits in brain connectivity have been reported in FASD patients; still, whether and how PAE affects the axonal development of neurons and disrupts the wiring between brain regions is not known. Here, we developed a mouse model of moderate alcohol exposure during prenatal brain wiring to study the impact of PAE on corpus callosum (CC) development, a major white matter tract reported to be affected in FASD patients. Our results show that PAE induces aberrant navigation of interhemispheric CC axons that persist even after the end of the exposure, causing their ectopic termination in the contralateral cortex. Furthermore, these defects in interhemispheric connectivity persist into adulthood and are associated with defective bilateral sensorimotor coordination in behavioral tasks requiring cortical control and interhemispheric communication. Finally, we identified neuronal miR-17-5p and its target Ephrin type A receptor 4 (EphA4) as mediators of the effect of alcohol on the contralateral targeting of CC axons. Taken together, our results suggest that alteration of miRNA-mediated regulation of axon guidance signaling by prenatal alcohol exposure affects interhemispheric cortical connectivity and associated behavior in FASD.
Assessment of lisavanbulin (BAL101553) as an anti-lymphoma agent
Authors: Spriano Filippo , Aresu Luca , Cascione Luciano , Risi Giorgia , Arribas Alberto J. , Napoli Sara , Rinaldi Andrea , Forster-Gross Nicole , Bachmann Felix , Engelhardt Marc , Lane Heidi , Bertoni Francesco 
Published: January 2023

AbstractMicrotubules are major components of the cellular cytoskeleton, ubiquitously founded in all eukaryotic cells. They are involved in mitosis, cell motility, intracellular protein and organelle transport, and maintenance of cytoskeletal shape. Avanbulin (BAL27862) is a microtubule-targeted agent (MTA) that promotes tumor cell death by destabilization of microtubules. Due to its unique binding to the colchicine site of tubulin, differently from other MTAs, avanbulin has previously shown activity in solid tumor cell lines. Its prodrug, lisavanbulin (BAL101553), has shown early signs of clinical activity, especially in tumors with high EB1 expression. Here, we assessed the preclinical anti-tumor activity of avanbulin in diffuse large B cell lymphoma (DLBCL) and the pattern of expression of EB1 in DLBCL cell lines and clinical specimens.Avanbulin showed a potentin vitroanti-lymphoma activity, which was mainly cytotoxic with potent and rapid apoptosis induction. Median IC50 was around 10nM in both activated B cell like (ABC) and germinal center B cell like (GCB) DLBCL. Half of the cell lines tested showed an induction of apoptosis already in the first 24h of treatment, the other half in the first 48h. EB1 showed expression in DLBCL clinical specimens, opening the possibility for a cohort of patients that could potentially benefit from treatment with lisavanbulin.These data show the basis for further preclinical and clinical evaluation of lisavanbulin in the lymphoma field.