bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial security of Ukrainian enterprises during the war and post-war period
Authors: Varnalii Zakharii , Bondarenko Snizhana 
Published: April 2023

The relevance of the problems of security of the state, society, enterprise and persons for Ukraine is not in doubt. Not only external negative factors (world pandemics, military conflicts, information propaganda, manipulation of public consciousness, cyber -terrorism, uncontrolled migration flows, aggravation and challenges for business entities and society, making it possible to look for and create new methods and tools for effective management. Unfortunately, internal factors that do not contribute to the financial security of the state and business: political instability, corruption, widespread practice of tax evasion and legalization (laundering) of proceeds obtained, uneven regional economic development and others. In view of this, the issue of financial security of business entities is of particular relevance. The issues of financial security of the enterprise are devoted to the study of foreign and domestic scientists. Paying the proper scientific and methodological value of existing scientific achievements, the problems of ensuring the financial security of the enterprise in war and post-war period remain poorly studied. The purpose of the study is to analyze the financial security of enterprises and ensure it in war and post - war recovery. The following research methods were used: comparison, analysis and synthesis, induction and deduction, generalization, systematization. The financial security management system is an orderly set of interrelated elements that form a single functional integrity intended for establishing and maintaining the optimal level of financial security. The coordination of the interaction of these elements largely depends on the success and efficiency of the functioning of the financial security management system of the enterprise.
Integration of the cryptocurrency market in the financial system of Ukraine: theoretical aspects
Authors: Kuzheliev Mykhailo 
Published: April 2023

The subject of the research is theoretical approaches to the formation and development of the cryptocurrency market and its integration into the national financial system. The purpose of the article is to determine the theoretical foundations of the functioning of the cryptocurrency market based on a systemic approach and to explore the possibilities of its integration into the financial system of Ukraine. Method or methodology of research. The article uses the methods of scientific abstraction, analysis and synthesis, generalization, systematic approach. Results of the article. The article examines the theoretical aspects of the economic category "cryptocurrency". A retrospective analysis of cryptographic money research was carried out. The largest cryptocurrencies by capitalization were studied and it was concluded that Bitcoin remains the leader in terms of price and level of capitalization among existing cryptocurrencies. The state of introduction and development of the cryptocurrency market in Ukraine is considered. In particular, the article presents Ukrainian companies that offer the purchase of their goods and services for cryptocurrency. The prospects for the use of cryptocurrencies in the financial system of Ukraine are outlined. Field of application of results. The results of the research can be used in the process of streamlining the legal framework regulating the circulation of virtual assets and electronic money. Conclusions. A significant potential for the development of the cryptocurrency market is seen in Ukraine. Currently, the issue of implementation, full legal and institutional support for the circulation of cryptocurrencies is open and relevant, but has certain inhibitions, which are caused by an objective factor – the war in the country.
Using the principles of the sharing economy as a method of increasing the efficiency of the enterprise in the post-war period
Authors: Mavrina Maryna , Belopolskiy Mykola 
Published: April 2023

Relevance of the research topic. Today, a big problem for enterprises is a significant decrease in demand for their products. The main reason for this is the destruction of critical infrastructure because of hostilities, high rates of inflation, a decrease in the real income of the population, and a humanitarian disaster in the south and east of the country. Formulation of the problem. Using, for example, diversification as a method of increasing the efficiency of production and sales of products is no longer enough. It is necessary to look for and use new tools to protect enterprises from declining sales. The purpose of the article is to apply the principle of rational consumption to ensure the efficiency of the enterprise in the post-war period. Results of the article. It was determined that the principle of rational consumption together with the use of technological solutions of subscription systems open wide prospects for domestic enterprises. After all, using the principles of the sharing economy will make it possible to modernize business processes in such a way that enterprises can provide their services hundreds of times cheaper than before and at the same time be profitable, significantly expand their geography and create long-term financial relations with their consumers. Field of application of results. The conclusions of the article can be used mainly at enterprises in the sphere of wholesale and retail trade, manufacturing. Conclusions. The activity of enterprises in the field of trade and production is accompanied by certain difficulties. Sales of non-essential goods will decrease in the coming years. To prevent the bankruptcy of enterprises that do not belong to industries that provide basic human needs, the managers of these enterprises can introduce the principles of the sharing economy to create attractive, and most importantly, affordable and mutually beneficial conditions for cooperation with target customers. These principles can be applied both in the B2B (business to business) and B2C (business to consumers) sectors.
Typing myalgic encephalomyelitis by infection at onset: A DecodeME study
Authors: Bretherick Andrew D. , McGrath Simon J. , Devereux-Cooke Andy , Leary Sian , Northwood Emma , Redshaw Anna , Stacey Pippa , Tripp Claire , Wilson Jim , Chowdhury Sonya , Lewis Isabel , Almelid Øyvind , Baby Sumy V. , Baker Tom , Becher Hannes , Boutin Thibaud , Clyde Malgorzata , Garcia Diana , Ireland John , Kerr Shona M. , McDowall Ewan , Perry David , Samms Gemma L. , Vitart Veronique , Wolfe Jareth C. , Ponting Chris P. 
Published: April 2023

Background: People with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) daily experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment or brain fog. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific breakthrough regarding their pathogenesis has been made. It remains unknown, despite decades of small-scale studies, whether individuals experience different types of ME/CFS separated by onset-type, sex or age. Methods: DecodeME is a large population-based study of ME/CFS that recruited 17,074 participants in the first 3 months following full launch. Their detailed questionnaire responses provided an unparalleled opportunity to investigate illness severity, onset, course and duration. Results: The well-established sex-bias among ME/CFS patients is evident in the initial DecodeME cohort: 83.5% of participants were females. What was not known previously was that females’ comorbidities and symptoms tend to be more numerous than males’. Moreover, being female, being older and being over 10 years from ME/CFS onset are significantly associated with greater severity. Five different ME/CFS onset types were examined in the self-reported data: those with ME/CFS onset (i) after glandular fever (infectious mononucleosis); (ii) after COVID-19 infection; (iii) after other infections; (iv) without an identified infectious onset; and, (v) where the occurrence of an infection at or preceding onset is not known. Conclusions: This revealed that people with a ME/CFS diagnosis are not a homogeneous group, as clear differences exist in symptomatology and comorbidity.
Bivalirudin Presents a Favorable Safety Profile Regarding Adverse Drug Reactions, Thrombocytopenia, and Bleeding in Chinese Patients With High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Prospective, Multi-Center, Intensive Monitoring Study
Authors: Peng Xiaoping , Li Zhenyong , Li Dunheng , Li Zhongyin , Lu Zhaohua , Luo Caidong , Ji Zheng 
Published: April 2023

BackgroundThis study aimed to comprehensively explore the occurrence and risk factors for adverse events (AEs) and adverse drug reactions (ADRs) (especially for thrombocytopenia and bleeding) in Chinese patients with high bleeding risk (older adults, or complicated with diabetes mellitus or renal function impairment) undergoing percutaneous coronary intervention (PCI) with bivalirudin as an anticoagulant.MethodsA total of 1,226 patients with high bleeding risk who received PCI with bivalirudin as an anticoagulant from 27 Chinese medical centers were enrolled in this prospective, multi-center, intensive monitoring study. AEs, ADRs, thrombocytopenia, and bleeding were collected from admission to 72 h post-bivalirudin administration; subsequently, patients were followed up on the 30th day with the safety data collected as well.ResultsAdverse events were observed in 198 (16.2) patients, among which severe AEs occurred in 16 (1.3%) patients. Meanwhile, bivalirudin-related ADRs were reported in 66 (5.4%) patients, among which 5 (0.4%) patients experienced bivalirudin-related severe ADRs. Besides, thrombocytopenia and bleeding occurred in 45 (3.7%) and 19 (1.5%) patients, respectively. The subsequent multivariate logistic analysis revealed that age &gt;75 years [p = 0.017, odds ratio (OR) = 1.856] and spontaneous coronary artery dissection (SCAD) (p = 0.030, OR = 2.022) were independently related to higher ADR risk; SCAD (p = 0.017, OR = 2.426) was independently correlated with higher thrombocytopenia risk, while radial artery access (p = 0.015, OR = 0.352) was independently correlated with lower thrombocytopenia risk; and the administration of bivalirudin preoperatively or intraoperatively (p = 0.013, OR = 5.097) was independently associated with higher bleeding risk.ConclusionBivalirudin presents a favorable safety profile regarding ADRs, thrombocytopenia, and bleeding in Chinese patients with high bleeding risk undergoing PCI.
Associations between TyG-BMI and normal-high blood pressure values and hypertension: cross-sectional evidence from a non-diabetic population
Authors: Peng Nan , Kuang Maobin , Peng Yi , Yu Hang , Zhang Shuhua , Xie Guobo , Sheng Guotai , Zou Yang 
Published: April 2023

ObjectiveTriglyceride glucose body mass index (TyG-BMI) has been shown to be strongly associated with a variety of chronic diseases. However, little is known about the associations between TyG-BMI and normal-high blood pressure (BP) values and hypertension (HTN).MethodThe current study was cross-sectional in design and included 15,464 non-diabetic participants recruited between 1994 and 2016 in the NAGALA (NAfld in the Gifu Area, Longitudinal Analysis) study. Associations between TyG-BMI and normal-high BP values and HTN were assessed using multivariate logistic regression. The ability of the TyG index, BMI, and their combined index TyG-BMI to identify normal-high BP values and HTN was compared by receiver operating characteristic (ROC) curves.ResultsAmong the 15,464 eligible non-diabetic participants, 28.56% (4,416/15,464) and 6.23% (964/15,464) had normal-high BP values and HTN, respectively. Multivariate logistic regression analysis showed positive correlations between BMI, TyG index, TyG-BMI and normal-high BP values/HTN; after standardized regression coefficients, TyG-BMI had the strongest association with normal-high BP values and HTN compared to BMI and TyG index. In the fully adjusted model, the odds ratio (OR) value corresponding to the relationship between TyG-BMI and HTN/normal-high BP values was 2.35; when TyG-BMI was used as a categorical variable, compared with the lowest quartile of TyG-BMI the regression coefficient for the association of the highest quartile of TyG-BMI with normal-high BP values increased by 426%, while the regression coefficient for the association with HTN increased by 527%. In further spline regression analysis, we also found that there was a linearly positive correlation between TyG-BMI and systolic BP/diastolic BP (SBP/DBP), which supported the linear trend between TyG-BMI and HTN/normal-high BP values (P-trend &lt;0.0001). In addition, ROC analysis showed that TyG-BMI had good diagnostic values for both normal-high BP values and HTN, and TyG index combined with BMI can significantly improve the ability of a single index to identify normal-high BP values and HTN.ConclusionIn the non-diabetic population, TyG-BMI showed a significant positive correlation with both normal-high BP values and HTN, and TyG-BMI was of higher value for the identification of both normal-high BP values and HTN compared to BMI and TyG index alone.
Probiotics fortify intestinal barrier function: a systematic review and meta-analysis of randomized trials
Authors: Zheng Yanfei , Zhang Zengliang , Tang Ping , Wu Yuqi , Zhang Anqi , Li Delong , Wang Chong-Zhi , Wan Jin-Yi , Yao Haiqiang , Yuan Chun-Su 
Published: April 2023

BackgroundProbiotics play a vital role in treating immune and inflammatory diseases by improving intestinal barrier function; however, a comprehensive evaluation is missing. The present study aimed to explore the impact of probiotics on the intestinal barrier and related immune function, inflammation, and microbiota composition. A systematic review and meta-analyses were conducted.MethodsFour major databases (PubMed, Science Citation Index Expanded, CENTRAL, and Embase) were thoroughly searched. Weighted mean differences were calculated for continuous outcomes with corresponding 95% confidence intervals (CIs), heterogeneity among studies was evaluated utilizing I2 statistic (Chi-Square test), and data were pooled using random effects meta-analyses.ResultsMeta-analysis of data from a total of 26 RCTs (n = 1891) indicated that probiotics significantly improved gut barrier function measured by levels of TER (MD, 5.27, 95% CI, 3.82 to 6.72, P &lt; 0.00001), serum zonulin (SMD, -1.58, 95% CI, -2.49 to -0.66, P = 0.0007), endotoxin (SMD, -3.20, 95% CI, -5.41 to -0.98, P = 0.005), and LPS (SMD, -0.47, 95% CI, -0.85 to -0.09, P = 0.02). Furthermore, probiotic groups demonstrated better efficacy over control groups in reducing inflammatory factors, including CRP, TNF-α, and IL-6. Probiotics can also modulate the gut microbiota structure by boosting the enrichment of Bifidobacterium and Lactobacillus.ConclusionThe present work revealed that probiotics could improve intestinal barrier function, and alleviate inflammation and microbial dysbiosis. Further high-quality RCTs are warranted to achieve a more definitive conclusion.Clinical trial registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=281822, identifier CRD42021281822.
HIV, opioid use, and alterations to the gut microbiome: elucidating independent and synergistic effects
Authors: Satish Sanjana , Abu Yaa , Gomez Daniel , Kumar Dutta Rajib , Roy Sabita 
Published: April 2023

BackgroundThe microbiome is essential to immune development, defense against pathogens, and modulation of inflammation. Microbial dysbiosis has been reported in various diseases including human immunodeficiency virus (HIV) and opioid use disorder (OUD). Notably, people living with HIV (PLWH) have been reported to both have higher rates of OUD and use opioids at higher rates than the general public. Thus, studying gut microbial alterations in people living with HIV and with OUD could elucidate mechanisms pertaining to how these conditions both shape and are shaped by the microbiome. However, to date few studies have investigated how HIV and OUD in combination impact the microbiome.Aim of reviewHere, we review previous studies outlining interactions between HIV, opioid use, and microbial dysbiosis and describe attempts to treat this dysbiosis with fecal microbial transplantation, probiotics, and dietary changes.Key scientific concepts of reviewWhile the limited number of studies prevent overgeneralizations; accumulating data suggest that HIV and opioid use together induce distinct alterations in the gut microbiome. Among the three existing preclinical studies of HIV and opioid use, two studies reported a decrease in Lachnospiraceae and Ruminococcaceae, and one study reported a decrease in Muribaculaceae in the combined HIV and opioid group relative to HIV-alone, opioid-alone, or control groups. These bacteria are known to modulate immune function, decrease colonic inflammation, and maintain gut epithelial barrier integrity in healthy individuals. Accordingly, modulation of the gut microbiome to restore gut homeostasis may be attempted to improve both conditions. While mixed results exist regarding treating dysbiosis with microbial restoration in PLWH or in those with opioid dependency, larger well-defined studies that can improve microbial engraftment in hosts hold much promise and should still be explored.
Modified ground calcium carbonate mineral powder using in asphalt concrete: modification mechanism characterization at macro and micro levels
Authors: Zhang Zijun , Yan Wenda 
Published: April 2023

The study investigated the modification mechanism of modified ground calcium carbonate (GCC) mineral powder using in asphalt concrete. Two types of Titanate coupling agents, namely, K38S (TCA-K38S) and 201 (TCA-201), as well as sodium stearate coupling agent, were adopted to prepare modified GCC. The optimized preparation process was obtained through the orthogonal test. Two kinds of modified GCC were preferably selected to prepare asphalt concrete according to modification mechanism characterization, their performance was analyzed and evaluated at macro and micro levels. The study results show that, the optimal scheme of sodium stearate modified GCC is modification temperature of 80°C, modification time of 50 min, modifying agent dosage of 2.0%. The crystal structure of GCC remains unchanged after modification, with the original lattice structure being maintained. TCA-201 and sodium stearate exhibit better coating properties than that of TCA-K38S. The contact angles of TCA-201 and sodium stearate modified GCC are larger than that of TCA-K38S modified GCC. The in-service performance of AC-13C asphalt concrete modified with sodium stearate is found to be superior to that of TCA-201 modified AC-13C asphalt concrete. Compared with the unmodified AC-13C asphalt concrete, the Marshall modulus, residual stability, freeze-thaw splitting strength ratio, and maximum flexural tensile strain of sodium stearate modified AC-13C asphalt concrete are increased by 54.55%, 2.73%, 10.47%, and 26.41% respectively. This paper provides theoretical guidance for the application of GCC mineral powder in asphalt concrete.
Mental workload during endoscopic sinus surgery is associated with surgeons’ skill levels
Authors: Suzuki Masanobu , Miyaji Kou , Matoba Kotaro , Abe Takashige , Nakamaru Yuji , Watanabe Ryosuke , Suzuki Takayoshi , Nakazono Akira , Konno Atsushi , Hinder Dominik , Psaltis A. J. , Wormald P. J. , Homma Akihiro 
Published: April 2023

IntroductionSurgeons’ mental workload during endoscopic sinus surgery (ESS) has not been fully evaluated. The assessment was challenging due to the great diversity of each patient’s anatomy and the consequence variety of surgical difficulties. In this study, we examined the mental workload of surgeons with various surgical skill levels during ESS under the standardized condition provided by novel-designed 3D sinus models.Materials and methodsForty-seven participants performed a high-fidelity ESS simulation with 3D-printed sinus models. Surgeons’ mental workload was assessed with the national aeronautics and space administration-task load index (NASA-TLX). Associations between the total and subscales score of NASA-TLX and surgical skill index, including the board certification status, the number of experienced ESS cases, and the objective structured assessment of technical skills (OSATS), were analyzed. In addition, 10 registrars repeated the simulation surgery, and their NASA-TLX score was compared before and after the repetitive training.ResultsThe total NASA-TLX score was significantly associated with OSATS score (p = 0.0001). Primary component analysis classified the surgeons’ mental burden into three different categories: (1) the skill-level-dependent factors (temporal demand, effort, and performance), (2) the skill-level-independent factors (mental and physical demand), and (3) frustration. After the repetitive training, the skill-level-dependent factors were alleviated (temporal demand; z = −2.3664, p = 0.0091, effort; z = −2.1704, p = 0.0346, and performance; z = −2.5992, p = 0.0017), the independent factors were increased (mental demand; z = −2.5992, p = 0.0023 and physical demand; z = −2.2509, p = 0.0213), and frustration did not change (p = 0.3625).ConclusionSome of the mental workload during ESS is associated with surgical skill level and alleviated with repetitive training. However, other aspects remain a burden or could worsen even when surgeons have gained surgical experience. Routine assessment of registrars’ mental burdens would be necessary during surgical training to sustain their mental health.
General Public’s knowledge, awareness, and perception of Cardiometabolic diseases: data from a Singapore study population
Authors: Anand Vickram Vijay , Goh Rachel Sze Jen , Nah Benjamin , Koh Sky Wei Chee , Lim Jieyu , Neo Nicholas W. S. , Chew Jocelyn , Lee Yuan Ying , Chin Yip Han , Chong Bryan , Kong Gwyneth , Tan Bryan , Low Zhiwen , Khoo Chin Meng , Goh Lay Hoon , Loh Poay Huan , Chai Ping , Dalakoti Mayank , Chan Mark , Foo Roger , Muthiah Mark , Chew Nicholas W. S. 
Published: April 2023

BackgroundHealth literacy and illness perception play crucial roles in tackling the cardiometabolic disease epidemic. We aim to compare the attitudes, knowledge, self-perceived risks and actions taken, between individuals with and without metabolic risk factors (MFs).MethodsFrom 5 June to 5 October 2022, participants of the general public were invited to complete a self-administered questionnaire. MF status was defined as the presence of hypertension, hyperlipidemia, diabetes mellitus and/or current/previous smoking. Participants were assessed based on four categories (knowledge-based, attitude-based, perceived risk, and action-based) of questions pertaining to four cardiometabolic diseases – diabetes mellitus, hypertension, hyperlipidemia, and non-alcoholic fatty liver disease.ResultsA total of 345 participants were enrolled, of whom 34.5% had at least one MF. Compared to those without MFs, participants with MFs had lower knowledge scores, but higher perceived risk scores across all cardiometabolic diseases. The largest knowledge gap pertained to hypertension-related questions. After adjustment, linear regression demonstrated that the presence of MFs (β:2.752, 95%CI: 0.772–4.733, p = 0.007) and higher knowledge scores (β:0.418, 95%CI: 0.236–0.600, p &lt; 0.001) were associated with higher perceived risk. Despite increased perceived risk in those with MFs, this translated to only few increased self-reported preventive actions, when compared to those without MFs, namely the reduction in red meat/processed food consumption (p = 0.045) and increase in fruits/vegetables consumption (p = 0.009).ConclusionThis study identified a vulnerable subpopulation living with MFs, with high perceived risks, and discordant levels of knowledge and preventive actions taken. Nationwide efforts should be channeled into addressing the knowledge-to-action gap.