bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Cultural Exchange, Women’s Leadership, and Advocacy: Connecting the Hudson Valley and the Gaza Strip Through WhatsApp
Authors: Hajjaj Noura 
Published: February 2023

AbstractThis chapter details the challenges of mutual digital communication, particularly pressing in light of the geopolitics of the blockade in the Gaza Strip, where conditions are deteriorating and many live below the poverty line. I became acquainted with these challenges through the process of founding and implementing an initiative to connect student refugees in Gaza with undergraduate student interlocutors in the United States. As part of the outreach, participants reflected upon the historical background of the crisis of refugee displacement in the Gaza Strip—the world’s third most densely populated territory. Student conversations, via WhatsApp video chats and voice messenger, also forged intercultural bridges and encouraged leadership. The experience in a nontraditional classroom environment promoted student advocacy and enriched the curriculum for both U.S. students and students in Gaza learning about civic engagement.
Education Can’t Wait for LGBTIQ Refugees? Exploring Inclusion and Access to Higher Education in Kakuma Refugee Camp
Authors: Carron Djemila , O’Keeffe Paul 
Published: February 2023

AbstractHigher education in refugee contexts has, in recent years, emerged as a key humanitarian response and development imperative within the international forced migration management space (ECRE 2016). Humanitarian organizations and authorities active in the global forced migration management system have, to varying degrees, instituted and facilitated access to higher education opportunities for many refugees within the confines of refugee camps or the close proximity of host communities (Ferede 2018). Under the broad, sometimes vague, guidance of global development initiatives such as the sustainable development goals (Sawadogo 2016), the raison d’etre of higher education has been positioned as an enabling tool for the economic, social and emotional empowerment of refugees (Brugha and Hollow 2017).
Intrathorakale Unterdrucktherapie des Pleuraempyems unter Einsatz einer offenporigen Drainagefolie
Authors: Betz Viktoria , van Ackeren Vera , Scharsack Ernst , Stark Bettina , Müller Christian Theodor , Loske Gunnar 
Published: February 2023

Zusammenfassung
Einleitung
Anhand einer Fallserie berichten wir über unsere ersten Erfahrungen mit einer intrathorakalen Unterdrucktherapie (ITNPT) in der stadienadaptierten Therapie des Pleuraempyems (PE).

Material und Methoden
Die ITNPT ist eine Weiterentwicklung der Unterdrucktherapie für die intrathorakale Anwendung. Nach thoraxchirurgischem offenen Débridement wurde ein intrathorakaler Unterdruckverband installiert. Als Drainageelemente verwendeten wir eine dünne offenporige doppellagige Drainagefolie (OF) mit offenporigen Polyurethanschäumen (PUS). Ausschließlich die OF wurde in direktem Kontakt zum Lungenparenchym angelegt. Die Unterdruckerzeugung erfolgte mit einer elektronischen Pumpe (kontinuierlicher Sog, −75 mm Hg). In der Revisionthorakotomie wurde je nach Lokalbefund die ITNPT beendet oder fortgeführt.

Ergebnisse
Es wurden 31 Patienten im PE-Stadium II und III behandelt. Die ITNPT erfolgte bereits beim Primäreingriff (n = 17) oder bei Revision (n = 14). Die ITNPT erfolgte über einen Dauer von m = 10 Tagen (2–18 Tage), Wechselintervall m = 4 d (2–6 d). Die intrathorakaler Unterdruckverband-Anlage wurde in m = 3,5 (1–6) mal vorgenommen.
Die Empyemhöhle verkleinerte und reinigte sich unter dem Sog kontinuierlich. Die OF hat ein minimales Eigenvolumen bei maximaler Resorptionsoberfläche. Nach Anlage des Unterdrucks besteht kein intrathorakales Totvolumen, das Parenchym kann sich entfalten.

Diskussion
Die schonenden Materialeigenschaften der OF ermöglichen die ITNPT zur Behandlung des Pleuraempyems. Es ist eine gezielte lokale intrathorakale Sanierung des septischen Focus in Ergänzung zur operativen Therapie möglich. Das Behandlungsregime erfordert wiederholte operative Verbandswechsel. Die Methode ist geeignet zur Behandlung komplizierter PIeuraempyeme im Stadium II und III.

Konklusion
Die OF kann als intrathorakales Drainageelement zur ITNPT bei Pleuraempyemen verwendet werden. Das Indikationsspektrum der Unterdrucktherapie erweitert sich um diese neue Anwendungsoption.
Cardiovascular effects of bufotenin on human 5-HT4 serotonin receptors in cardiac preparations of transgenic mice and in human atrial preparations
Authors: Neumann Joachim , Schulz Nils , Fehse Charlotte , Azatsian Karyna , Čináková Aneta , Marušáková Margaréta , Hofmann Britt , Gergs Ulrich 
Published: February 2023

Abstract
It is unclear whether bufotenin (= N,N-dimethyl-serotonin = 5-hydroxy-N,N-dimethyl-tryptamine), a hallucinogenic drug, can act on human cardiac serotonin 5-HT4 receptors. Therefore, the aim of the study was to examine the cardiac effects of bufotenin and for comparison tryptamine in transgenic mice that only express the human 5-HT4 receptor in cardiomyocytes (5-HT4-TG), in their wild-type littermates (WT) and in isolated electrically driven (1 Hz) human atrial preparations. In 5-HT4-TG, we found that both bufotenin and tryptamine enhanced the force of contraction in left atrial preparations (pD2 = 6.77 or 5.5, respectively) and the beating rate in spontaneously beating right atrial preparations (pD2 = 7.04 or 5.86, respectively). Bufotenin (1 µM) increased left ventricular force of contraction and beating rate in Langendorff perfused hearts from 5-HT4-TG, whereas it was inactive in hearts from WT animals, as was tryptamine. The positive inotropic and chronotropic effects of bufotenin and tryptamine were potentiated by an inhibitor of monoamine oxidases (50 µM pargyline). Furthermore, bufotenin concentration- (0.1–10 µM) and time-dependently elevated force of contraction in isolated electrically stimulated musculi pectinati from the human atrium and these effects were likewise reversed by tropisetron (10 µM). We found that bufotenin (10 µM) increased the phosphorylation state of phospholamban in the isolated perfused hearts, left and right atrial muscle strips of 5-HT4-TG but not from WT and in isolated human right atrial preparations. In summary, we showed that bufotenin can increase the force of contraction via stimulation of human 5-HT4 receptors transgenic mouse cardiac preparations but notably also in human atrial preparations.
Universal, School-Based Mental Health Program Implemented Among Racially and Ethnically Diverse Youth Yields Equitable Outcomes: Building Resilience for Healthy Kids
Authors: Chandrasekhar Jessica L. , Bowen Anne E. , Heberlein Erin , Pyle Emily , Studts Christina R. , Simon Stacey L. , Shomaker Lauren , Kaar Jill L. 
Published: February 2023

AbstractAlthough suicide is a leading cause of mortality among racial and ethnic minority youth, limited data exists regarding the impact of school-based mental health interventions on these populations, specifically. A single-arm pragmatic trial design was utilized to evaluate the equity of outcomes of the universal, school-based mental health coaching intervention, Building Resilience for Healthy Kids. All sixth-grade students at an urban middle school were invited to participate. Students attended six weekly sessions with a health coach discussing goal setting and other resilience strategies. 285 students (86%) participated with 252 (88%) completing both pre- and post-intervention surveys. Students were a mean age of 11.4 years with 55% identifying as girls, 69% as White, 13% as a racial minority, and 18% as Hispanic. Racial minority students exhibited greater improvements in personal and total resilience compared to White students, controlling for baseline scores.
Magnetite-impregnated biochar of parthenium hysterophorus for adsorption of Cr(VI) from tannery industrial wastewater
Authors: Fito Jemal , Abewaa Mikiyas , Nkambule Thabo 
Published: February 2023

AbstractThe tannery industry inevitably generates toxic and catastrophic wastewater, which results in a huge threat to public health and water resources. Therefore, this work aimed to synthesize parthenium hysterophorus-based biochar–Fe3O4 composite for removal of Cr(VI) from tannery wastewater under 34 full factorial experimental designs of the Box–Behnken, which was analyzed using response surface methodology under four independent factors of pH (3, 6, and 9), initial Cr(VI) concentrations (40, 70, and 100 mg/L), contact times (30, 60, and 90 min), and adsorbent doses (20, 60, and 100 mg/100 mL). This composite adsorbent was described by a high BET surface area of 237.4 m2/g, XRD prominent peaks, SEM morphology corroborate and FTIR multifunctionalities of O–H at 3296 cm−1, the vibration of ketone C–OH at 1240 cm−1, and the vibration of C–O–C at 1147 cm−1 and Fe–O stretching at 542 cm−1. The maximum Cr(IV) removal efficiency of 91.8% was recorded at an initial Cr(VI) concentration of 40 mg/L, pH of 3, adsorbent dose of 100 mg/100 mL, and a contact time of 90 min, whereas the minimum Cr(VI) removal of 17.3% was observed at an initial Cr(VI) concentration of 100 mg/L, 20 mg/100 mL of adsorbent dose, pH of 9, and contact time of 30 min. The concentration of Cr(VI) in real wastewater was determined to be 85.13 mg/L and its remediation was found to be 81.8%. Langmuir’s model was the best fit with experimental data at R2 0.99 and qmax 400 mg/g, showing that the adsorption process was homogenous and monolayer. In conclusion, the adsorption results were encouraging, and biochar–Fe3O4 appears to be a potential candidate for Cr removal from wastewater.
Novel AIP mutation in exon 6 causing acromegaly in a German family
Authors: Detomas M. , Altieri B. , Flitsch J. , Saeger W. , Korbonits M. , Deutschbein T. 
Published: February 2023

AbstractThe most frequent genetic alteration of familial isolated growth hormone producing pituitary neuroendocrine tumors is a germline mutation of the aryl hydrocarbon receptor-interacting protein (AIP) gene. Various AIP mutations are already known; however, an AIP mutation in exon 6 (c.811_812del; p.Arg271Glyfs*16) has not been reported yet. Here, we report a German family with two identical twins who were both affected by acromegaly and carried the above-mentioned novel AIP mutation. The father was found to be an unaffected carrier, while the paternal aunt most likely suffered from acromegaly as well and died from metastatic colorectal cancer. Apart from reporting a novel AIP mutation, this study does not only highlight the different clinical and histological features of the AIP mutated growth hormone producing pituitary neuroendocrine tumors but also confirms the poor responsiveness of dopamine agonists in AIP mutated acromegaly. Furthermore, it highlights the increased mortality risk of comorbidities typically associated with acromegaly.
Bi-indicator driven surrogate-assisted multi-objective evolutionary algorithms for computationally expensive problems
Authors: Wang Wenxin , Dong Huachao , Wang Peng , Shen Jiangtao 
Published: February 2023

AbstractThis paper presents a bi-indicator-based surrogate-assisted evolutionary algorithm (BISAEA) for multi-objective optimization problems (MOPs) with computationally expensive objectives. In BISAEA, a Pareto-based bi-indictor strategy is proposed based on convergence and diversity indicators, where a nondominated sorting approach is adopted to carry out two-objective optimization (convergence and diversity indicators) problems. The radius-based function (RBF) models are used to approximate the objective values. In addition, the proposed algorithm adopts a one-by-one selection strategy to obtain promising samples from new samples for evaluating the true objectives by their angles and Pareto dominance relationship with real non-dominated solutions to improve the diversity. After the comparison with four state-of-the-art surrogate-assisted evolutionary algorithms and three evolutionary algorithms on 76 widely used benchmark problems, BISAEA shows high efficiency and a good balance between convergence and diversity. Finally, BISAEA is applied to the multidisciplinary optimization of blend-wing-body underwater gliders with 30 decision variables and three objectives, and the results demonstrate that BISAEA has superior performance on computationally expensive engineering problems.
Energy efficiency trends in the Greek building sector: a participatory approach
Authors: Karakosta Charikleia , Papapostolou Aikaterini 
Published: February 2023

AbstractEnergy efficiency (EE) is one of the most effective ways to reduce energy consumption, secure the energy supply and achieve a country’s environmental targets while preserving business as usual in most economic sectors. In order to achieve efficient energy use, updates to industrial processes, building stock and other sectors are needed, and, thus, capital should be redirected to energy efficiency investments. Nevertheless, project developers usually struggle to find finance for their project ideas since there is a knowledge gap between them and financing institutions, who, most of the time, have no technical background to assess the profitability that emerges from the multidimensional benefits of energy efficiency measures. An analysis of the current situation, while also identifying the main barriers and difficulties that policymakers and EE professionals are facing, is crucial to developing a feasible plan for increasing EE measures in the building sector. The aim of this study is to analyse the EE situation in the Greek building stock by utilizing a stakeholder engagement approach involving highly relevant key actors, gathering their input, and depicting it in statistical analysis. The results of the study reveal that the building’s EE profile is considered an asset for long-term capital investments, while a lack of capital, high costs and the pandemic of 2019 compose some of the major factors that hinder the implementation of EE measures.
Deprescribing, Polypharmacy and Prescribing Cascades in Older People with Type 2 Diabetes: A Focused Review
Authors: Hickman Elizabeth , Gillies Clare , Khunti Kamlesh , Seidu Samuel 
Published: February 2023

AbstractDeprescribing is the process by which medications are reduced without compromising safety to the patient (Jude et al. in 2022 Diabetes Ther 13: 619–634, 2022). The purpose of this narrative review is to discuss deprescribing as a topic, firstly discussing the benefits and pitfalls to such pharmacological interventions along with the current barriers and enablers to such a controversial topic, and then discussing deprescribing with respect to preventive medications, namely those that reduce the long term impacts of a condition or disease. Research that has previously focused on reducing polypharmacy has highlighted the benefits of such interventions, including reduction of adverse reactions or complications, improved patient satisfaction and quality of life, and improved cost effectiveness and drug compliance. Some potential harms that have been highlighted include an increased number of complications, increased symptoms of previously dampened conditions, and negligible changes in patient satisfaction that have stressed the importance of this intervention being patient centred and individualized to each patient. The implementation of deprescribing processes could drastically change the way people think about deprescribing and could be extremely beneficial to older patients living with type 2 diabetes worldwide. Developments in preventive medication deprescribing could pave the way for this intervention to become more common place improving the quality of life in patient’s final years.
Synthesis of biochar/clay mineral nanocomposites using oil shale semi-coke waste for removal of organic pollutants
Authors: Zhao Feng , Mu Bin , Zhang Tenghe , Dong Chunjuan , Zhu Yongfeng , Zong Li , Wang Aiqin 
Published: February 2023

AbstractDue to the poor surface/interfacial interaction and the large gaps in the size and microstructure between biomass and clay mineral, it was difficult to adjust the structure and performance of biochar/clay mineral composites at the molecular level. Herein, oil shale semi-coke composed of multi-minerals and organic matters was used as a promising precursor to prepare biochar/clay mineral nanocomposites via phosphoric acid-assisted hydrothermal treatment followed by KOH activation for removal of organic pollutants from aqueous solution. The results revealed that the nanocomposites presented well-defined sheet-like morphology, and the carbon species uniformly anchored on the surface of clay minerals. With the changes in the pore structure, surface charge and functional groups after two-step modification, the nanocomposites exhibited much better adsorption property toward organic pollutants than the raw oil shale semi-coke, and the maximum adsorption capacities of methylene blue, methyl violet, tetracycline, and malachite green were 165.30 mg g−1, 159.02 mg g−1, 145.89 mg g−1, and 2137.36 mg g−1, respectively. The adsorption mechanisms involved electrostatic attraction, π–π stacking and hydrogen bonds. After five consecutive adsorption–desorption, there was no obvious decrease in the adsorption capacity of malachite green, exhibiting good cyclic regeneration performance. It is expected to provide a feasible strategy for the preparation of biochar/clay mineral nanocomposites with the excellent adsorption performances for removal of organic pollutants based on full-component resource utilization of oil shale semi-coke.
Graphical Abstract
Clarifying the Factor structure of the Intolerance of Uncertainty Inventory: Measurement Invariance and Validity in Predicting Clinical Outcomes
Authors: Zahrayi Tara , Saed Omid , Lauriola Marco 
Published: February 2023

AbstractThe Intolerance of Uncertainty Inventory (IUI) is a two-part inventory assessing the general unacceptability of uncertainty in terms of generalized maladaptive beliefs (IUI-A) and specific individuals’ reactions to uncertainty, such as avoidance, doubt, overestimation of threat, worry, control of uncertainty, and seeking reassurance (IUI-B). Previous research has examined the factor structure of both parts with mixed results, especially for IUI-A. The present study took advantage of the Farsi-language version to clarify the IUI factor structure, assess measurement invariance between clinical and nonclinical samples, and examine the criterion-related and incremental validity of IUI-A and IUI-B. We administered the IUI to a mixed psychiatric sample of patients who met DSM-IV criteria for affective disorders (N = 198) and community participants in relatively good health (N = 427). Exploratory structural equation modeling analyses were used to test alternative factor models and determine whether IUI factors predicted depression and anxiety symptoms. A bifactor model was found to be the best fit for IUI-A and IUI-B, and reliability analyses supported the use of the total scores for both parts. The IUI-A and IUI-B were scalar invariant. The general factors of each part and the IUI-B worry factor were higher in patients with affective disorders than in community participants. Validity analyses showed that the two general factors tapped into the same variance in depression and anxiety symptoms as the competing instruments, although not superior in predictive performance to the Intolerance of Uncertainty scale (IUS-12) and the Disorder Specific Intolerance of Uncertainty (DSIU) scale. The present study clarified the factorial structure of the IUI and provided evidence that IUI total scores are reliable and valid for assessing the Intolerance of Uncertainty construct and predicting clinical outcomes.
Midline crossing right pulmonary veins with dual drainage to the left atrium
Authors: Padovani Paul , Grunenwald Gronier Céline , Baruteau Alban-Elouen 
Published: February 2023

AbstractWe report the exceptional case of transcatheter treatment of a partial anomalous pulmonary venous drainage of the right lung to the innominate vein and dual drainage to the left atrium.
Global Perspectives: Thoughts on the Ever-changing Landscape of International Legal Research
Authors: Breslin Jas 
Published: February 2023

AbstractThis article, by Jas Breslin, is a summary of a panel discussion held at the BIALL Conference in July 2022, an in-depth and absorbing debate with a focus on the changes in legal research across the globe over the last decade. Entitled ‘Thoughts on the ever-changing landscape of international legal research’, the discussion saw four panellists from different working environments explain exactly what international legal research meant to them, and what significant transformations they have witnessed in recent years. Interestingly, some universal key themes emerged during the discussion, regardless of the jurisdiction or sector the speaker worked in.
Law Librarians as Copyright Specialists: the Perfect Match?
Authors: Faulkner Kate , Lynwood Wendy 
Published: February 2023

AbstractThis article, written by Kate Faulkner and Wendy Lynwood, considers the skills of law librarians and shows how they can assist those who also hold a copyright specialist role. Most librarians encounter some aspects of copyright within their role. However, the understanding that law librarians have with regard to law, legal research capabilities, teaching and liaison skills equips them to take on copyright, sometimes in addition to their law library role, or to move into a full-time copyright specialist role.
Multiple-image super-resolution of cryo-electron micrographs based on deep internal learning
Authors: Huang Qinwen , Zhou Ye , Liu Hsuan-Fu , Bartesaghi Alberto 
Published: February 2023

Abstract
Single-particle cryo-electron microscopy (cryo-EM) is a powerful imaging modality capable of visualizing proteins and macromolecular complexes at near-atomic resolution. The low electron-doses used to prevent radiation damage to the biological samples, however, result in images where the power of the noise is 100 times greater than the power of the signal. To overcome these low signal-to-noise ratios (SNRs), hundreds of thousands of particle projections are averaged to determine the three-dimensional structure of the molecule of interest. The sampling requirements of high-resolution imaging impose limitations on the pixel sizes that can be used for acquisition, limiting the size of the field of view and requiring data collection sessions of several days to accumulate sufficient numbers of particles. Meanwhile, recent image super-resolution (SR) techniques based on neural networks have shown state-of-the-art performance on natural images. Building on these advances, here, we present a multiple-image SR algorithm based on deep internal learning designed specifically to work under low-SNR conditions. Our approach leverages the internal image statistics of cryo-EM movies and does not require training on ground-truth data. When applied to single-particle datasets of apoferritin and T20S proteasome, we show that the resolution of the 3D structure obtained from SR micrographs can surpass the limits imposed by the imaging system. Our results indicate that the combination of low magnification imaging with in silico image SR has the potential to accelerate cryo-EM data collection by virtue of including more particles in each exposure and doing so without sacrificing resolution.