bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning–Based Summertime Turbulence Intensity Estimation Using Satellite Observations
Authors: Lee Yoonjin , Kim Soo-Hyun , Noh Yoo-Jeong , Kim Jung-Hoon 
Published: September 2023

Abstract
Turbulence is what we want to avoid the most during flight. Numerical weather prediction (NWP) model–based methods for diagnosing turbulence have offered valuable guidance for pilots. NWP-based turbulence diagnostics show high accuracy in detecting turbulence in general. However, there is still room for improvements such as capturing convectively induced turbulence. In such cases, observation data can be beneficial to correctly locate convective regions and help provide corresponding turbulence information. Geostationary satellite data are commonly used for upper-level turbulence detection by utilizing its water vapor band information. The Geostationary Operational Environmental Satellite (GOES)-16 carries the Advanced Baseline Imager (ABI), which enables us to observe further down into the atmosphere with improved spatial, temporal, and spectral resolutions. Its three water vapor bands allow us to observe different vertical parts of the atmosphere, and from its infrared window bands, convective activity can be inferred. Such multispectral information from ABI can be helpful in inferring turbulence intensity at different vertical levels. This study develops U-Net based machine learning models that take ABI imagery as inputs to estimate turbulence intensity at three vertical levels: 10–18, 18–24, and above 24 kft (1 kft ≈ 300 m). Among six different U-Net-based models, U-Net3+ model with a filter size of three showed the best performance against the pilot report (PIREP). Two case studies are presented to show the strengths and weaknesses of the U-Net3+ model. The results tend to be overestimated above 24 kft, but estimates of 10–18 and 18–24 kft agree well with the PIREP, especially near convective regions.

Significance Statement
Turbulence is directly related to aviation safety as well as cost-effective aircraft operation. To avoid turbulence, turbulence diagnostics are calculated from numerical weather prediction (NWP) model outputs and are provided to pilots. The goal of this study is to develop a satellite data–driven machine learning model that estimates turbulence intensity in three different vertical layers to provide additional information along with the NWP-based turbulence diagnostics. Validation results against pilot reports show that the machine learning model performs comparable to NWP-based turbulence diagnostics. Furthermore, results with different channel selections reveal that using multiple water vapor channels can help extract additional information for estimating turbulence intensity at lower levels.
The impact of access to electricity on mental health in conflict-affected territories: An exploratory study in Gaza
Authors: AbuQamar Mazen , Eltayyan Dalia , Kuznetsova Irina , Dhesi Surindar , Catling Jonathan , AL-Dadah Raya , Saad Mahmoud , Abuhaiba Mohammad 
Published: September 2023

Background: Access to affordable and clean energy is an essential component of the Sustainable Development Goals and a determinant of physical and mental health. However, the occupied Palestinian territory, the Gaza Strip, has experienced prolonged issues with electricity, water and gas supplies. This has significantly impacted on daily life and the area is on the verge of disaster. This research focused on the mental health effects of the lack of electricity in Gaza which have not been previously documented. Methods: A cross-sectional analytic approach was adopted. A survey was administrated face-to-face with respondents from 350 participating households. Inferential statistical analysis was used to examine the relationship between the domains of anxiety, depression, wellbeing and electricity supply factors. A multiple linear regression model was also utilised. Results: There is a highly statistically significant link between continuity of electricity and level of anxiety ( p < .001). The same effect was reported in the level of depression, and a higher level was observed among residents with an intermittent or disrupted electricity supply, with a statistically significant link between the level of depression and continuity of electricity. Conclusion: Electricity issues, especially when combined with other stressors associated with living in Gaza, lead to serious mental health concerns. Urgent attention must be given to developing sustainable, reliable and affordable energy supplies for short- and long-term health and community development.
“At the End of the Day, My Goal is to Help People Feed Their Babies Human Milk”: A Qualitative Exploration of the Pumping Attitudes of Lactation Care Providers
Authors: Anders Lisa A. , Yasin Reham 
Published: September 2023

Background: Parents who express milk by pumping often feel this is judged as inferior to direct breastfeeding by healthcare providers, leaving parents feeling unsupported. Healthcare provider attitudes can influence decisions about human milk feeding directly at the chest. Yet, there is a gap in knowledge regarding lactation care provider attitudes about pumping. Research Aim: To explore the attitudes and feelings of lactation care providers about pumping. Method: A qualitative descriptive design was utilized. Researchers conducted semi-structured interviews with a convenience sample of 15 lactation care providers in the United States, recruited via social media. Data were analyzed using thematic analysis. Results: Four themes emerged: (1) I Support You, (2) But It’s Not the Same, (3) Frustration with Social Media, and (4) Changing Perspectives. Participants held positive attitudes toward pumping as a tool to meet human milk feeding goals. They strived to provide judgement-free support but stressed the importance of setting realistic expectations and sharing the difference in benefits and work between direct breastfeeding and pumping. Providers held negative attitudes about the portrayal of pumping on social media. The participants’ perspectives were that, while there has been stigma surrounding pumping in the past, views are changing. Conclusion: Lactation care providers strive to provide judgement-free support for pumping, but communicating challenges about pumping may be perceived negatively by parents. More research is needed on lactation care provider education on pumping, interventions to reduce bias, and how these affect providers’ pumping beliefs, attitudes, and provision of judgement-free delivery of care.
Applying the healthcare failure mode and effects analysis approach to improve the quality of an organised colorectal cancer screening programme
Authors: Chiereghin Angela , Squillace Lorena , Pizzi Lorenzo , Bazzani Carmen , Roti Lorenzo , Mezzetti Francesca 
Published: September 2023

Objective The first level of a colorectal cancer (CRC) screening process was systematically analysed using the Healthcare Failure Mode and Effects Analysis (HFMEA) approach by a multidisciplinary team aiming to improve the programme quality. Setting The study was conducted at the Local Health Authority of Bologna, Northern Italy. Methods Seven brainstorming sessions were conducted and all the activities performed were recorded on a FMEA worksheet consisting of individual records reporting the specific phases of the analysed process along with associated activities, possible failure modes, their causes and effects, the obtained risk priority numbers (RPNs) and the control measures to plan. Results Twenty-three failure modes, 14 effects and 12 possible causes were identified. Nine failure modes were prioritised according to the RPN obtained; most resulted in possible false-negative faecal immunochemical test (FIT) results (66.7%), followed by sample loss (22.2%) and not reaching the entire target population (11.1%). This leads to 66.7% of corrective/preventive actions being applied to the phase of returning the stool sample by the citizen. For this phase reorganisation, the local pharmacies were involved not only as FIT kit delivery points but also as specimen collection and sending points to the laboratory. These organisational changes allowed the introduction of complete traceability of kits and specimens flow, as well as temperature control. A re-evaluation of the prioritised failure modes 6 months after launching the implemented screening process showed that HFMEA application decreased the risk of potential errors by 75.9%. Conclusion HFMEA application in CRC screening programme is a useful tool to reduce potential errors.
Comparison of Infrared Thermometer with Digital Thermometer in Neonates During Delivery Room Care
Authors: Behura Sushree Smita , Hasa Vetsa Snigdha , Jena Chinmay , Panda Santosh Kumar 
Published: September 2023

Objective To compare an infrared thermometer (IRT) at the forehead with a Digital thermometer (DT) at the axillary site in neonates in the delivery room. Methods Temperature was assessed simultaneously in 65 neonates born at ≥34 weeks in the delivery room with IRT at the forehead site and DT at the axillary site at 1 and 5 min of age. Immediately after delayed cord clamping, skin-to-skin contact (SSC) was given for vaginal-born neonates, and a radiant warmer was used for cesarean-born neonates. Results In a total of 130 paired measurements, the intraclass correlation coefficient (ICC) between the IRT and the DT was good, ICC = 0.859, P < 0.001; the bias (SD) was –0.16(0.42)°C in Bland-Altman analysis. The correlation between IRT and DT during SSC was ICC = 0.881, P < .001, and the bias (SD) was –0.14(0.33)°C; and for neonates cared under radiant warmer, the ICC was 0.846, P < .001 with bias (SD) of –0.17(0.47)°C. Conclusion Temperature assessed by IRT at the forehead site shows good reliability with DT at the axillary site in neonates for thermal management in the delivery room.
Systemic Inflammatory Biomarkers Predict Survival of Patients Treated With Tyrosine Kinase Inhibitors for Metastatic Renal Cell Carcinoma
Authors: Wang Zhaojuan , Qin Yujie , Chai Xuxia , Lu Lina , Xue Ping , Lu Runrun , Miao Chengrui , Ma Haimei , Hu Xiaoyi , Yao Jiaxi 
Published: September 2023

Objective We aimed to retrospectively investigate whether the neutrophil to lymphocyte ratio (NLR) and the monocyte to lymphocyte ratio (MLR) can predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib or sorafenib. Methods We retrospectively identified 210 patients with mRCC treated with sunitinib or sorafenib from 2007 to 2017 at Fudan University- and Hexi University-affiliated hospitals. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan–Meier method. Multivariate regression analysis was used to evaluate predictors of PFS and OS. Results Low NLR (<2.85) and MLR (<.30) were strongly associated with increased PFS and OS. Multivariable analyses verified that the NLR and MLR were both independent prognostic factors. Additionally, the NLR was negatively correlated with CD8+ and CD4+ T-cell infiltration in tumors. Conclusion In patients with mRCC treated with sunitinib and sorafenib, an NLR <2.85 and MLR <.30 was associated with superior PFS and OS, which may be related to the reduced lymphocytic infiltration of tumors.
The Elevator Technique: A New Bailout Maneuver to Achieve Target Vessel Patency During Challenging BEVAR
Authors: Lerisson Erol , Le Houérou Thomas , Rockley Mark , Gaudin Antoine , Costanzo Alessandro , Fabre Dominique , Haulon Stéphan 
Published: September 2023

Purpose: The purpose of the study is to describe a new bailout maneuver for use during branched endovascular thoracoabdominal aneurysm repair (BEVAR) while dealing with challenging target vessel cannulation. Technique: A 54-year-old woman underwent urgent BEVAR with a low-profile T-branch device to exclude a type 2 thoracoabdominal aneurysm (TAAA). The endovascular procedure was challenging because the left renal artery ostium was covered by the endograft fabric, compounded by diseased target vessels. A novel bailout maneuver is described. After angioplasty of the left renal artery (LRA), the LRA remained precannulated and a low-profile T-branch was implanted. The 3 proximal branches (superior mesenteric artery, inferior mesenteric artery, and the right renal artery) were connected to their respective target vessels swiftly with a steerable sheath from a femoral approach. Access to the left renal artery was not achieved because it was obstructed by the fully deployed endograft. We subsequently stented the LRA over the “pre-positioned buddy wire,” using a balloon-expandable covered stent protruding inside the aneurysm lumen. The proximal stent was then flared and lifted upward using an 8.5 Fr steerable sheath, which made cannulation and stenting of the LRA through the side-branch from above finally achievable. Conclusion: The elevator technique described in this article will help achieve technical success in challenging BEVAR cases. Clinical Impact We describe in this technical note the “elevator technique” that will complement the “Snare-Ride” and “Balloon Anchoring” techniques over a buddy wire positioned in a target vessel, to provide successful bailout options for challenging TV cannulations during BEVAR.After failed access to the renal artery through the renal branch, a covered stent was implanted in the renal artery over the buddy wire with 10 mm protruding into the aortic lumen. This stent was then flared, prior to advancing a curved steerable sheath into the stent, which shaped it with a superior-facing funneled aortic segment. This maneuver resulted in the renal stent facing its corresponding branch, finally easy to access from the endograft lumen.
Association between radioulnar impingement and salvage surgical procedures of the distal radioulnar joint: influence of confounding variables
Authors: Hernández-Cortés Pedro , Catena Andrés , Hernández-Peregrina Pedro , Elizondo-Espósito Diana , Pajares-López Miguel , Rosales Roberto S. 
Published: September 2023

We conducted an ambispective cohort study to assess the association between symptomatic radioulnar impingement syndrome (SRUIS) and distal radioulnar joint (DRUJ) salvage surgery to examine the influence of confounders on the final effect. The outcome variable was the incidence of SRUIS and the exposure variable was the surgical procedure. Seventy-two patients with median age of 48 years (IQR 25–78) were examined using bivariate and logistic regression multivariate analyses, and confounders were analysed in 15 multivariate models. Overall, SRUIS occurred in 21 patients (29%). Bivariate analysis showed a significant association between SRUIS and type of surgical procedure, observed in 71% after Sauvé–Kapandji, 50% after Bowers and 15% after Darrach procedure. When adjusted for age, aetiology and previous surgery, the significant association disappeared. Confounding is an important factor when accounting for SRUIS after DRUJ salvage surgery. The risk of SRUIS did not depend on the procedure, but rather on patient’s age, aetiology and previous surgery. Level of evidence: II
Risks of Increased Operative Time and Longer Hospital Stays Based on Age in Total Ankle Arthroplasty
Authors: Peairs Emily M. , Anastasio Albert T. , Kim Billy , Walley Kempland , Adams Samuel B. 
Published: September 2023

Background As total ankle arthroplasty (TAA) is increasingly performed in younger individuals in the United States, the aim of this study was to analyze TAA outcomes and complications by age. Methods A total of 1619 primary and revision TAAs from 2012 to 2020 were collected and included from the National Surgical Quality Improvement Program. Patients were stratified by age into those younger than 55 years, between 55 and 70 years, and older than 70 years. Demographics, medical comorbidities, American Society of Anesthesiology Physical Classification (ASA) class, operative time, 30-day complications, and comorbid conditions were compared by univariable analysis. Multivariable analysis was used to analyze readmission rates, reoperation rates, operative time, and hospital length of stay. Results Patients younger than 55 years were found to have a significantly longer operative time compared to patients older than 70 years of age or between 55 and 70 years (P < .001, P = .034). Patients older than 70 years were found to have a significantly longer hospital stay (P < .001) and a greater risk of discharging to a nonhome location (P < .001). By multivariable analysis, patients 55 to 70 have a statistically lower risk of readmission compared to the other 2 cohorts (P = .043). No difference in postoperative complications was demonstrated between the different groups. Conclusions As the incidence of total ankle arthroplasty increases across all ages, it is important to understand specific perioperative risks for each age group. Younger patients tended to have longer surgeries and higher body mass indexes (BMIs). Patients aged 55 to 70 years had the lowest risks for perioperative complications. Patients greater than 70 years were at risk for longer hospital stays and discharge to nonhome locations. There were no differences in postoperative complications by age. Level of Evidence: Level III: Retrospective comparative study
Displaced Geriatric Femoral Neck Fractures: A Retrospective Comparison of Total Hip Arthroplasties Versus Hemiarthroplasty
Authors: Morgan Steven , Jarvis Stephanie , Conti Alexander , Staudinger Kelsey , Reynolds Cassandra , Bar-Or David 
Published: September 2023

Introduction Controversary exists around the best surgical management for traumatic geriatric displaced femoral neck fractures. The study objective was to compare outcomes among those managed with a total hip arthroplasty (THA) to those managed with a hemiarthroplasty (HA). Methods This retrospective matched cohort study included geriatric hip fractures (≥65 y/o) admitted 7/1/16-3/31/20. Patients were matched on having an advanced directive, pre-existing dementia, and age. Outcomes included: time to surgery, length of stay (LOS), blood loss volume, and discharge destination. THAs were compared to HAs; an alpha of <.05 indicated statistical significance. Results There were 191 patients: 86% were treated with HA and 14% with THA. Most (40%) were 80-89 years old, 66% were female, and 92% were white. After matching, the groups were well balanced on demographics and baseline characteristics with 27 patients/arm. The median time to surgery was 23 hours for both arms, P = .38. The LOS was significantly longer for those managed with a HA when compared to those managed with a THA, 5.6 vs 4.0 days, P = .001. The median blood loss volume was significantly lower for HAs than for THAs, but the difference was small, 100 vs 120 mL, P = .02. Patients managed with a HA were less likely to be discharged home than those managed with a THA, 22% vs 70%, P = .005. Conclusions While patients managed with a THA had significantly more blood loss than those managed with a HA, the difference in blood loss was small and not clinically relevant. Those managed with a THA experienced a significantly shorter LOS and were more likely to be discharged home than patients managed with a HA. Among a healthier, younger geriatric population, THA may lead to shortened LOS and improved discharge destinations when compared to HA for treatment of femoral neck fractures.
Cavitation Diagnostics Based on Self-Tuning VMD for Fluid Machinery with Low-SNR Conditions
Authors: Liu Hao , Tong Zheming , Shang Bingyang , Tong Shuiguang 
Published: September 2023

AbstractVariational mode decomposition (VMD) is a suitable tool for processing cavitation-induced vibration signals and is greatly affected by two parameters: the decomposed number K and penalty factor α under strong noise interference. To solve this issue, this study proposed self-tuning VMD (SVMD) for cavitation diagnostics in fluid machinery, with a special focus on low signal-to-noise ratio conditions. A two-stage progressive refinement of the coarsely located target penalty factor for SVMD was conducted to narrow down the search space for accelerated decomposition. A hybrid optimized sparrow search algorithm (HOSSA) was developed for optimal α fine-tuning in a refined space based on fault-type-guided objective functions. Based on the submodes obtained using exclusive penalty factors in each iteration, the cavitation-related characteristic frequencies (CCFs) were extracted for diagnostics. The power spectrum correlation coefficient between the SVMD reconstruction and original signals was employed as a stop criterion to determine whether to stop further decomposition. The proposed SVMD overcomes the blindness of setting the mode number K in advance and the drawback of sharing penalty factors for all submodes in fixed-parameter and parameter-optimized VMDs. Comparisons with other existing methods in simulation signal decomposition and in-lab experimental data demonstrated the advantages of the proposed method in accurately extracting CCFs with lower computational cost. SVMD especially enhances the denoising capability of the VMD-based method.
Iron oxide polyaniline-coated nanoparticles modulate tumor microenvironment in breast cancer: an in vitro study on the reprogramming of tumor-associated macrophages
Authors: Nascimento Camila Sales , Tavares Naiara Clemente , Batista Izabella Cristina Andrade , Caetano Mônica Maria Magalhães , de Oliveira Eneida Santos , Colombarolli Stella Garcia , Lage Anna Carolina Pinheiro , Corrêa-Oliveira Rodrigo , Alves Érica Alessandra Rocha , de Melo Celso Pinto , Calzavara-Silva Carlos Eduardo 
Published: September 2023

Abstract
Background
Breast cancer is the neoplastic disease with the highest incidence and mortality in the female population worldwide. Treatment remains challenging due to various factors. Therefore, it is of great importance to develop new therapeutic strategies that promote the safe destruction of neoplastic cells without compromising patients' quality of life. Among advances in the treatment of breast cancer, immunotherapy stands out as a promising trend. Recent studies have demonstrated the potential of iron oxide nanoparticles in promoting the reprogramming of M2 macrophages (pro-tumor phenotype) into M1 macrophages (anti-tumor phenotype) within the tumor microenvironment, resulting in potent antitumor effects. In this study, the effect of polyaniline-coated iron oxide nanoparticles (Pani/y-Fe2O3) on macrophage polarization and breast cancer cell death was investigated.

Methods
The non-cytotoxic concentration of nanoparticles was determined using the MTT assay. For in vitro co-culture experiments, breast cancer cell lines MCF -7 and MDA-MB -231 and macrophages THP-1 were co-cultured in a Transwell system and then the effects of Pani/y-Fe2O3 on cell viability, gene expression, cytokine profile, and oxidative stress markers were investigated.

Results
The results showed that Pani/y-Fe2O3 nanoparticles induced M2-to-M1 macrophage polarization in both cell lines through different pathways. In MCF -7 and THP-1 macrophage co-culture, the study showed a decrease in cytokine levels IL -1β, upregulation of M1-associated genes (IL-12, TNF-α) in macrophages, resulting in increased MCF -7 cell death by apoptosis (caspase 3/7+). In MDA-MB -231 co-cultures, increases in cytokines IL -6, IL -1β, and oxidative stress markers were observed, as well as upregulation of the inducible nitric oxide synthase (iNOS) gene in macrophages, leading to tumor cell death via apoptosis-independent pathways (Sytox+).

Conclusions
These findings highlight the potential of Pani/y-Fe2O3 as a promising therapeutic approach in the context of breast cancer treatment by effectively reprogramming M2 macrophages into an anti-tumor M1 phenotype, Pani/y-Fe2O3 nanoparticles demonstrated the ability to elicit antitumor effects in both MCF-7 and MDA-MB-231 breast cancer cell lines.