bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplantation of in vitro prefabricated adipose organoids attenuates skin fibrosis by restoring subcutaneous fat and inducing dermal adipogenesis
Authors: Quan Yuping , Zhang Yuteng , Li Jian , Lu Feng , Cai Junrong 
Published: July 2023

AbstractLocalized scleroderma is a complex autoimmune disease characterized by dermal fibrosis and loss of cutaneous fat. While cytotherapy offers a promising treatment option, stem cell transplantation results in low survival rates and fails in target cell differentiation. In this study, we aimed to prefabricate syngeneic adipose organoids (ad‐organoids) using microvascular fragments (MVFs) via three‐dimensional (3D) culturing and transplant them beneath the fibrotic skin to restore subcutaneous fat and reverse the pathological manifestation of localized scleroderma. We employed 3D culturing of syngeneic MVFs with stepwise angiogenic and adipogenic induction to produce ad‐organoids and evaluated their microstructure and paracrine function in vitro. C57/BL6 mice with induced skin scleroderma were treated with adipose‐derived stem cells (ASCs), adipocytes, ad‐organoids, and Matrigel, and the therapeutic effect was assessed histologically. Our results showed that ad‐organoids derived from MVF contained mature adipocytes and a well‐established vessel network, secreted multiple adipokines, promoted adipogenic differentiation of ASCs, and suppressed proliferation and migration of scleroderma fibroblasts. Subcutaneous transplantation of ad‐organoids reconstructed the subcutaneous fat layer and stimulated dermal adipocyte regeneration in bleomycin‐induced scleroderma skin. It reduced collagen deposition and dermal thickness, attenuating dermal fibrosis. Moreover, ad‐organoids suppressed macrophage infiltration and promoted angiogenesis in the skin lesion. In conclusion, 3D culturing of MVFs with stepwise angiogenic and adipogenic induction is an effective strategy for the fabrication of ad‐organoids, and the transplantation of prefabricated ad‐organoids can improve skin sclerosis by restoring cutaneous fat and attenuating skin fibrosis. These findings offer a promising therapeutic approach for the treatment of localized scleroderma.
Definition, Measurement, Precursors, and Outcomes of Trust Within Health Care Teams: A Scoping Review
Authors: Hamilton Ailsa Lauren , Layden Elizabeth A. , Storrar Neill , Skinner Janet , Harden Jeni , Wood Morwenna 
Published: July 2023

AbstractPurposeThis scoping review aims to map the breadth of the literature examining how trust is defined in health care teams, describe what measurements of trust are used, and investigate the precursors and outcomes of trust.MethodFive electronic databases (Ovid MEDLINE, CINAHL, PsycInfo, Embase, and ASSIA [Applied Social Sciences Index and Abstracts]) were searched alongside sources of gray literature in February 2021. To be included, studies needed to discuss a health care team directly involved in managing patient care and one aspect of trust as a relational concept. A content count of the definitions of trust and tools used to measure trust and a deductive thematic analysis of the precursors and outcomes of trust in health care teams were conducted.ResultsUltimately, 157 studies were included after full-text review. Trust was the main focus of 18 (11%) studies and was not routinely defined (38, 24%). Ability appeared to be key to the definition. Trust was measured in 34 (22%) studies, often using a bespoke measure (8/34, 24%). The precursors of trust within health care teams occur at the individual, team, and organizational levels. The outcomes of trust occur at the individual, team, and patient levels. Communication was a broad overarching theme that was present at all levels, both as a precursor and outcome of trust. Respect, as a precursor, influenced trust at the individual, team, and organizational levels, while trust influenced learning, an outcome, across the patient, individual, and team levels.ConclusionsTrust is a complex, multilevel construct. This scoping review has highlighted gaps in the literature, including exploration of the swift trust model, which may be applicable to health care teams. Furthermore, knowledge from this review may be integrated into future training and health care practices to optimize team processes and teamworking.
Supraventricular Tachycardia in the Setting of Neonatal COVID-19 Infection
Authors: Karamantziani Theoni , Lianou Loukia , Zampouni Dimitra , Koustouki Vasiliki , Lipsou Niki , Bouza Helen 
Published: July 2023

Background:
COVID-19 infection, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may present with a wide range of clinical presentations and a variety of symptoms in neonates. The cardiovascular manifestations that have been described in the setting of COVID-19 infection in neonates are tachycardia and hypotension, but information regarding cardiac arrhythmias is scarce, while the effect of SARS-CoV-2 on myocardial function is still not well established.

Clinical Findings:
We present a case of a neonate admitted with fever and nasal congestion.

Primary Diagnosis:
The neonate was tested positive for SARS-CoV-2. Supraventricular tachycardia (SVT) was diagnosed during his hospitalization in the neonatal intensive care unit.

Interventions:
The neonate was under treatment with intravenous fluid repletion, intravenous broad-spectrum antibiotics, and continuous hemodynamic monitoring. SVT resolved spontaneously, while the team was preparing application of further supportive measures with a bag of ice on the infant's face.

Outcomes:
The neonate was discharged in good condition on day 14 post-admission, with no further recurrence of SVT. Follow-up visits were scheduled with the cardiologist.

Practice Recommendations:
SVT in full-term or premature neonates can be a clinical manifestation of COVID-19 infection. Both neonatologists and neonatal nurse practitioners should be prepared to deal with cardiological manifestations of COVID-19 infection in neonates.
Update on autoinflammatory diseases
Authors: Ashari Kosar Asna , Hausmann Jonathan S. , Dedeoglu Fatma 
Published: July 2023

Purpose of review
Although the concept of systemic autoinflammatory diseases (SAIDs) is still very young, our knowledge about them is exponentially growing. In the current review, we aim to discuss novel SAIDs and autoinflammatory pathways discovered in the last couple of years.

Recent findings
Advances in immunology and genetics have led to the discovery of new pathways involved in autoinflammation, as well as several new SAIDs, including retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache (ROSAH syndrome), vacuoles, E1 enzyme, X-linked autoinflammatory somatic (VEXAS) syndrome, TBK1 deficiency, NEMO deleted exon 5 autoinflammatory syndrome (NDAS), and disabling pansclerotic morphea. Progress in immunobiology and genetics has also brought forth novel treatments for SAIDs. Personalized medicine has made significant progress in areas such as cytokine-targeted therapies and gene therapies. However, much work remains, especially in measuring and improving the quality of life in patients with SAIDs.

Summary
In the current review, we discuss the novelties in the world of SAIDs, including mechanistic pathways of autoinflammation, pathogenesis, and treatment. We hope this review helps rheumatologists to gain an updated understanding of SAIDs.
Update on treatment responses and outcome measure development in chronic nonbacterial osteomyelitis
Authors: Ramachandran Shwetha , Zhao Yongdong , Ferguson Polly J. 
Published: July 2023

Purpose of review
To review recent trends in treatment and recent progress in developing outcome measures needed for chronic nonbacterial osteomyelitis (CNO) clinical trials.

Recent findings
CNO is an autoinflammatory bone disease. In a minority of patients, the disease is genetically driven, and diagnosis can be made by DNA sequencing. However, for nonsyndromic CNO there is no diagnostic test. The number of children with CNO appears to be increasing and damage is common. Increases in CNO diagnosis is due to raised awareness, increased availability of whole-body magnetic resonance imaging and rising incidence. Treatment remains empiric and it is unclear which second line treatment is superior. Tumor necrosis factor inhibitors (TNFi) and bisphosphonates continue to be used as second line agents for nonsteroidal anti-inflammatory drugs (NSAID) refractory CNO; newer immune modulatory medications are used if this fails. Validated classification criteria, clinical outcome measures and imaging scoring standards are needed for successful clinical trials.

Summary
Best treatment for NSAID refractory CNO remains unclear. Classification criteria, clinical outcomes measures and standardized imaging scoring have been developed or are near completion. This will facilitate robust clinical trials in CNO with the goal of having approved medications for this painful disease.
Quantifying Muscle Size Asymmetry in Adolescent Idiopathic Scoliosis Using Three-dimensional Magnetic Resonance Imaging
Authors: Duncombe Phoebe , Izatt Maree T. , Pivonka Peter , Claus Andrew , Little J. Paige , Tucker Kylie 
Published: July 2023

Study Design:
This is a case-control study of prospectively collected data.

Objective:
To quantify paraspinal muscle size asymmetry in adolescent idiopathic scoliosis (AIS) and determine if this asymmetry is i) greater than observed in adolescent controls with symmetrical spines; and ii) positively associated with skeletal maturity using Risser grade, scoliosis severity using the Cobb angle, and chronological age in years.

Summary of Background Data:
AIS is a three-dimensional deformity of the spine which occurs in 2.5-3.7% of the Australian population. There is some evidence of asymmetry in paraspinal-muscle activation and morphology in AIS. Asymmetrical paraspinal muscle forces may facilitate asymmetrical vertebral growth during adolescence.

Methods:
An asymmetryindex [Ln(concave/convex volume)] of i) deep and ii) superficial paraspinal-muscle volumes, at the level of the i) major curve apex (Thoracic 8-9th vertebral level) and ii) lower-end vertebrae (LEV, Thoracic 10-12th vertebral level), was determined from 3D Magnetic Resonance Imaging (MRI) of 25 adolescents with AIS (all right thoracic curves), and 22 healthy controls (convex=left); all female, 10-16 years.

Results:
Asymmetryindex of deep paraspinal-muscle volumes was greater in AIS (0.16±0.20) than healthy spine controls (-0.06±0.13) at the level of the apex (P<0.01, linear mixed-effects analysis), but not LEV (P>0.05). Asymmetryindex was positively correlated with Risser grade (r=0.50, P<0.05) and scoliosis Cobb angle (r=0.45, P<0.05), but not age (r=0.34, P>0.05). There was no difference in the asymmetryindex of superficial paraspinal muscle volumes between AIS and controls (P>0.05).

Conclusions:
The asymmetry of deep apical paraspinal-muscle volume in AIS at the scoliosis apex is greater than that observed at equivalent vertebral levels in controls and may play a role in the pathogenesis of AIS.
Giant Pilomatrix Carcinoma of the Thorax: An Uncommon and Clinically Misdiagnosed Tumor
Authors: Nikolaidou Eirini , Papadopoulou Sophia , Tzimorota Zoi , Pipinia Argiro , Stampou Panagiota , Karagergou Eleni 
Published: July 2023

Summary:
Pilomatrix carcinoma is an unusual and aggressive malignant tumor deriving from follicular matrix cells and exhibiting a metastatic potential to lungs and regional lymph nodes in 10% of cases. We report the case of a 54-year-old male patient who presented with a biopsy-proven malignant pilomatrixoma of the thoracic region, which recurred multiple times after previous excisions. Due to the size of the tumor (28 by 22 cm), wide excision and axillary lymphadenectomy of levels I and II were performed, followed by reconstruction with a free deep inferior epigastric artery perforator flap and adjuvant radiotherapy. Owing to its rarity, this tumor can initially be misdiagnosed, resulting in delayed treatment and recurrences if inadequately excised. Also, large tumor size is correlated with a higher incidence of metastasis. High index of clinical suspicion and wide excision are recommended, along with the need of establishing oncological guidelines for better prognosis.
Postinjury Alcohol Use Is Associated With Prolonged Recovery After Concussion in NCAA Athletes
Authors: Chang Roger C. , Singleton Michael , Chrisman Sara P. D. , Giza Christopher C. , Cuneo Ami Z. , Murinova Natalia , Broglio Steven P. , McCrea Michael , McAllister Thomas W. , Sharma Tara L. ,   For the CARE Consortium Investigators
Published: July 2023

Objective:To determine whether alcohol use leads to prolonged clinical recovery or increased severity of concussion symptoms in National Collegiate Athletic Association (NCAA) athletes.Design:Prospective observational study.Setting:Clinical institutions.Participants:Athletes from the NCAA Concussion Assessment Research and Education consortium who sustained a concussion from 2014 to 2021.Interventions:Athletes were divided into 2 groups, those reporting alcohol use postinjury and those reporting no alcohol use postinjury.Main Outcome Measures:Symptom recovery was evaluated as time (in days) from injury to clearance to return to unrestricted play (days until URTP). Severity of concussion symptoms was assessed using the Standardized Sport Concussion Assessment Tool (SCAT3) symptom severity, headache severity, difficulty concentrating, and difficulty remembering scores. These scores were taken a median of 6.6 [interquartile range (IQR) = 4.0-10] and 6 (IQR = 4.0-9.0) days after injury for those who did and did not consume alcohol postinjury respectively and compared with baseline SCAT3 scores.Results:Four hundred eighty four athletes from the data set had complete data for exposure and outcome. The adjusted mean number of days until URTP for athletes reporting alcohol use postinjury [23.3; 95% confidence interval (CI), 20.0-27.2; days] was incidence rate ratio (IRR) 1.32 (95% CI, 1.12-1.55;P< 0.001) times higher than for athletes who reported no alcohol use postinjury [17.7 (95% CI, 16.1-19.3) days]. Postinjury alcohol was not associated with severity of concussion symptoms (P's < 0.05).Conclusion:Self-reported postinjury alcohol use is associated with prolonged recovery but not severity of concussion symptoms in collegiate athletes. This may inform future clinical recommendations regarding alcohol consumption after concussion.
Effects of Motor Control Exercises in Patients With Chronic Nonspecific Low Back Pain: A Systematic Review and Meta-Analysis
Authors: Capel-Alcaraz Ana M. , Castro-Sánchez Adelaida M. , Matarán-Peñarrocha Guillermo A. , Antequera-Soler Eduardo , Lara-Palomo Inmaculada C. 
Published: July 2023

Objective:The primary objective of this systematic review is to assess whether motor control exercises consisting of the methodology described by Richardson and Hodges improve the pain and disability of patients with nonspecific low back pain.Design:Systematic review and a meta-analysis.Setting:A literature review was conducted using PubMed, PEDro, Scielo, CINAHL, Web of Science, Dialnet, Scopus, and MEDLINE from inception to November 2021.Patients:Patients with chronic nonspecific low back pain.Interventions:Randomized controlled trials assessing motor control exercises versus inactive control, placebo or minimal intervention, and other exercises.Main Outcome Measures:Pain intensity, disability, and physical activity were considered as primary outcomes.Results:Eighteen studies with 1356 patients were finally included in the systematic review, of which only 13 randomized clinical trials could be meta-analyzed. Statistically significant results were found in favor of the motor control group for the comparison with other exercises in disability at postintervention term (Mean Difference, 95% Confidence Interval [CI], −3.13 [−5.87 to −0.38],P= 0.03); for the comparison with inactive control, placebo, or minimal intervention in pain at postintervention term (MD, 95% CI, −18.10 [−30.79 to −5.41],P= 0.008); and for comparison with general exercises (MD, 95% CI, −12.70 [−20.80 to −4.60],P= 0.002).Conclusions:Moderate-quality evidence regarding the effectiveness of motor control exercises to reduce pain intensity and disability exists, but the reduction should be interpreted with caution.
Factors Related to Functional Capacity Deterioration in Surgical Lung Cancer Patients
Authors: Xu Xinyi , Liu Xiaohang , Ho Mu-Hsing , Chau Pui Hing , Cheung Denise Shuk Ting , Lin Chia-Chin 
Published: July 2023

Background
A decline in functional capacity is anticipated after lung resection. However, the factors related to functional capacity deterioration in surgical lung cancer patients have not been systematically reviewed.

Objective
To investigate the factors related to functional capacity deterioration and the trajectory of functional capacity after lung cancer surgery.

Methods
PubMed, CINAHL, Scopus, and SPORTDiscus were searched between January 2010 and July 2022. Two reviewers conducted a critical appraisal of individual sources. Twenty-one studies met the inclusion criteria.

Results
This review presents evidence for risk factors related to functional capacity deterioration after lung cancer surgery, including patient characteristics (age), preoperative clinical factors (vital capacity, quadriceps force, B-type natriuretic peptide level), surgery-related factors (surgical procedure, duration of chest tube drainage, postoperative complications), and postoperative clinical factor (C-reactive protein level). Most patients had a significant decline in functional capacity in the short term (≤1 month from surgery). In the medium term (1 to ≤6 months from surgery), although the functional capacity did not return to the preoperative level, the decline became insignificant.

Conclusions
This study is the first to review factors related to functional capacity in lung cancer patients. The findings can help clinicians to better identify patients at risk of functional capacity decline and allocate clinical resources more efficiently.

Implications for Practice
The risk factors related to the functional capacity decline in surgical lung cancer patients should be evaluated routinely during perioperative nursing assessments. Preoperative and postoperative nursing interventions can potentially improve modifiable risk factors and prevent functional capacity deterioration.
Serum and urethral antibody response in Mycoplasma genitalium-infected men
Authors: Kim Caroline M. , Manhart Lisa E. , Wood Gwendolyn E. 
Published: July 2023

ABSTRACT
The antibody response to Mycoplasma genitalium in serum and urethral secretions of men with non-gonococcal urethritis was examined longitudinally. Serum and urethral antibodies reacted primarily with the MgpB and MgpC adhesins. Serum antibodies persisted throughout follow-up while urethral antibodies waned despite organism persistence. Declining antibodies may facilitate chronic infection.
Factors associated with consenting to receive an automated email summary following a sexual health clinic visit
Authors: Huang Felicity , Fairley Christopher K. , Lee David M. , Rahman Rashidur , Ong Jason J. , Bradshaw Catriona S. , Chen Marcus Y. , Phillips Tiffany R. , Chow Eric P.F. 
Published: July 2023

ABSTRACT

Background
Electronic health records allow for inexpensive communication with patients. In March 2021, the Melbourne Sexual Health Centre (MSHC) implemented an automated email summary (“Sexual Health Automated Visit Email” (SHAVE)) of a client’s visit. This study evaluates the proportion of attendees at a sexual health service who opted in or out of SHAVE.

Methods
This study was conducted at MSHC in Australia between March 2021 and June 2022. Univariable and multivariable logistic regression analyses were used to examine the client characteristics associated with consenting to SHAVE.

Results
There were 18,528 clients (men: 12,700, women: 5,828) included in the final analysis and 55.2% (n = 10,233) consented to receiving SHAVE. Comparing to those who did not have a new STI diagnosis, clients with a new diagnosis of an STI, but not HIV, had lower odds of consenting to receiving SHAVE (chlamydia [aOR: 0.64; 95% CI: 0.57-0.72]; gonorrhoea [aOR: 0.71; 95% CI: 0.62-0.82]; syphilis [aOR: 0.75; 95% CI: 0.59-0.96]). Men had lower odds of consenting when compared to women (MSW [aOR: 0.77; 95% CI: 0.71-0.84] and MSM [aOR: 0.68; 95% CI: 0.62-0.75]). Comparing to those born in Australia or Oceania, clients born in Europe had lower odds of consenting (aOR: 0.81; 95% CI: 0.70-0.94) , whilst those born in Latin America or Caribbean had higher odds of consenting (aOR: 1.25; 95% CI: 1.04-1.51).

Conclusion
Email summaries may serve as a valuable strategy to improve health communication and record keeping for clients. Understanding the client characteristics associated with consenting SHAVE will allow for the implementation of strategies to better communicate with clients.
Are prior sexual risk behaviors associated with adherence to COVID-19 preventative behaviors among young Black men?
Authors: Ratnayake Aneeka , Campbell Mary Beth , Gomes Gérard , Kissinger Patricia J. 
Published: July 2023

Abstract

Background
Behavioral clustering is a phenomenon in which several risk or protective behaviors co-occur in an individual. We sought to determine if prior sexual risk behaviors among young Black men who have sex with women (MSW) could predict subsequent non-adherence to COVID-19 prevention behaviors.

Methods
Young Black MSW aged 15-24 previously enrolled in a community-based Chlamydia trachomatis (Ct) screening program were enrolled in a sub-study between May-June 2020 and asked about adherence to four COVID-19 recommended non-pharmaceutical prevention behaviors (hand washing, mask wearing, social distancing, and following stay at home orders). Data from the original study was used to elicit the follow pre-pandemic behaviors including: having multiple sex partners, inconsistent condom use, prior STI testing behaviors and substance use. Wilcoxon rank sum tests were used to assess the association between historic risk behaviors and COVID-19 behavior score.

Results
There were 109 men included in the analysis, with a mean age of 20.5 years (S.D. 2.0). Inconsistent condom use, multiple sex partners, and prior HIV/STI testing status were not associated with fewer COVID-19 preventive behaviors but men who used any non-prescription drugs (p = 0.001) or marijuana only (p = 0.028) had a lower median COVID-19 preventative score compared to those who did not engage in those activities.

Conclusion
While none of the sexual risk behavior variables were associated, self-reported non-prescription drug and marijuana use were both significant predictors of lower adherence to COVID-19 preventative behaviors among young Black men. Young men who use drugs may need additional support to promote COVID-19 preventative behavior uptake.