bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the intersection of culture and stewardship: Assessing how the most visited art museums promote their philanthropic missions
Authors: Pressgrove Geah , Waters Richard D. , Darrah Adrienne , Troy Cassandra 
Published: March 2023

AbstractThis manuscript provides a foundation of information to provide a benchmark for further understanding how culture impacts the presentation of art museums' mission as well as cultivating relationship with its supporters. Using content analysis methodology, the research investigates how a random sampling of the globe's most visited art museums incorporate Kelly's (1998, 2001) stewardship dimensions into their homepages and membership webpages as well as Hofstede's six cultural dimensions into the museums' “About Us” pages. Results from this investigation found that art museums widely use the reporting and relationship nurturing strategies to reach out to a broad range of supporters, but they fail to recognize and thank specific individuals or groups of supporters to deepen the relationship with their most ardent supporters. The intersection of stewardship strategies with Hofstede's cultural dimensions are also explored qualitatively based on patterns identified within the results.
Efficacy of non‐pharmacological interventions to reduce pain in children with sickle cell disease: A systematic review
Authors: van Veelen Sarah , Vuong Caroline , Gerritsma Jorn J. , Eckhardt Corien L. , Verbeek Sophie E. M. , Peters Marjolein , Fijnvandraat Karin 
Published: March 2023

AbstractBackgroundPain is the clinical hallmark of sickle cell disease (SCD) leading to hospitalization, psychological sequelae and a decreased health‐related quality of life. The aim of this systematic literature review is to evaluate the efficacy of non‐pharmacological interventions in reducing sickle cell related pain in children with SCD.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines, a comprehensive literature search up until October 2022 was performed to identify studies that investigated the efficacy of non‐pharmacological interventions on (1) pain frequency and/or intensity, and (2) analgesic and health service use in children with SCD until the age of 21. Both randomized controlled trials (RCTs) and quasi‐experimental designed (QED) studies were considered for inclusion.ResultsTen articles (five RCTs and five QED studies) with 422 participants were included. They investigated cognitive behavioural therapy (CBT) (n = 5), biofeedback (n = 2), massage (n = 1), virtual reality (n = 1) and yoga (n = 1). The majority of the interventions were psychological (n = 7) and were performed in the outpatient clinic (n = 6). CBT and biofeedback significantly reduced frequency and/or intensity of SCD‐related pain in outpatient settings, while virtual reality and yoga significantly reduced pain in inpatient settings. Biofeedback also significantly reduced analgesic use. None of the included articles reported reduced health service use.ConclusionNon‐pharmacological interventions may be effective in reducing pain in paediatric patients with SCD. However, due to the heterogeneity of the included studies a quantitative analysis could not be performed. Awaiting further supporting evidence, healthcare providers should consider implementing these interventions as valuable part of a comprehensive pain management strategy plan.
Psychological grit moderates the relation between lifetime stressor exposure and functional outcomes among HIV‐seropositive and HIV‐seronegative adults
Authors: Delfel Everett , Hammond Andrea , Shields Grant S. , Moore David J. , Slavich George M. , Thames April D. 
Published: March 2023

AbstractThe ability to maintain functional independence throughout the lifespan may be diminished among medically compromised and chronically stressed populations. People living with HIV are more likely to demonstrate functional impairment and report greater exposure to lifetime and chronic stressors than their seronegative counterparts. It is well‐known that exposure to stressors and adversity is associated with functional impairment outcomes. However, to our knowledge, no studies have examined how protective factors such as psychological grit mitigate the negative effects of lifetime and chronic stressor exposure on functional impairment, and how this association differs by HIV‐status. To address this issue, we studied associations between lifetime and chronic stressor exposure, grit, and functional impairment in 176 African American and non‐Hispanic White HIV‐seropositive (n = 100) and HIV‐seronegative (n = 76) adults, aged 24–85 (M = 57.28, SD = 9.02). As hypothesised, HIV‐seropositive status and lower grit, but not lifetime stressor exposure, were independently associated with more functional impairment. Moreover, there was a significant three‐way interaction between HIV‐status, grit, and lifetime stressor exposure, b = 0.07, p = 0.025, 95% CI [0.009, 0.135]. Specifically, lifetime stressor exposure was related to more functional impairment for HIV‐seronegative—but not HIV‐seropositive—adults who reported low levels of grit. These findings suggest that the protective effects of grit may differ across populations at risk for functional impairment.
COVID‐19 and climate change: The social‐psychological roots of conflict and conflict interventions during global crises
Authors: Burrows Brooke , Abellera Cierra , Markowitz Ezra M. 
Published: March 2023

AbstractThe current study reviews key social psychological mechanisms related to conflict and conflict resolution that manifest within both the coronavirus pandemic and climate change crises. The uncertainty, scale, and nature of both global crises generate various forms of individual‐ and group‐level conflicts that, mediated by psychological and cultural phenomena, impede beneficial action and sustainable adaptation. Specifically, we highlight five social psychological mechanisms (i.e., cognitive dissonance, responsibility diffusion, compassion fatigue, dehumanization, and competitive beliefs) known to interact with, produce, and amplify intrapersonal, interpersonal, and/or intergroup conflicts. We draw attention to how these mechanisms have been activated by the pandemic in ways that share important similarities with climate change and present evidence‐informed approaches to combating their contribution to conflict (i.e., motivating behavior change, implementing accountability mechanisms, creating collective action opportunities, fostering intergroup contact, and promoting perspective‐taking). By engaging social psychological research to better understand both the roots of conflict as well as outline potential individual, community, and societal responses that can help alleviate conflict during these global crises, we can increase our ability to successfully navigate and in some cases avoid future conflicts caused by climate change.This article is categorized under:
Perceptions, Behavior, and Communication of Climate Change > Behavior Change and Responses
Heavy neutral leptons at muon colliders
Authors: Li Peiran , Liu Zhen , Lyu Kun-Feng 
Published: March 2023

Abstract
The future high-energy muon colliders, featuring both high energy and low background, could play a critical role in our searches for new physics. The smallness of neutrino mass is a puzzle of particle physics. Broad classes of solutions to the neutrino puzzles can be best tested by seeking the partners of SM light neutrinos, dubbed as heavy neutral leptons (HNLs), at muon colliders. We can parametrize HNLs in terms of the mass mN and the mixing angle with ℓ-flavor Uℓ. In this work, we focus on the regime mN> O(100) GeV and study the projected sensitivities on the |Uℓ|2 − mN plane with the full-reconstructable HNL decay into a hadronic W and a charged lepton. The projected reach in |Uℓ|2 leads to the best sensitivities in the TeV realm.
J-shaped association between uric acid and breast cancer risk: a prospective case–control study
Authors: Fan Kexin , Sun Tengfei , Yin Fuzai 
Published: March 2023

Abstract
Background/aim
In terms of breast cancer risk, there is no consensus on the effect of uric acid (UA) levels. The aim of our study was to clarify the link between UA and breast cancer risk in a prospective case–control study and to find the UA threshold point.

Methods
We designed a case–control study with 1050 females (525 newly diagnosed breast cancer patients and 525 controls). We measured the UA levels at baseline and confirmed the incidence of breast cancer through postoperative pathology. We used binary logistic regression to study the association between breast cancer and UA. In addition, we performed restricted cubic splines to evaluate the potential nonlinear links between UA and breast cancer risk. We used threshold effect analysis to identify the UA cut-off point.

Results
After adjusting for multiple confounding factors, we found that compared with the referential level (3.5–4.4 mg/dl), the odds ratio (OR) of breast cancer was 1.946 (95% CI 1.140–3.321) (P < 0.05) in the lowest UA level and 2.245 (95% CI 0.946–5.326) (P > 0.05) in the highest level. Using the restricted cubic bar diagram, we disclosed a J-shaped association between UA and breast cancer risk (P-nonlinear < 0.05) after adjusting for all confounders. In our study, 3.6 mg/dl was found to be the UA threshold which acted as the optimal turning point of the curve. The OR for breast cancer was 0.170 (95% CI 0.056–0.512) to the left and 1.283 (95% CI 1.074–1.532) to the right of 3.6 mg/dl UA (P for log likelihood ratio test < 0.05).

Conclusion
We found a J-shaped association between UA and breast cancer risk. Controlling the UA level around the threshold point of 3.6 mg/dl provides a novel insight into breast cancer prevention.
Impact of tumor markers on diagnosis, treatment and prognosis in CNS germ cell tumors: correlations with clinical practice and histopathology
Authors: Takami Hirokazu , Graffeo Christopher S. , Perry Avital , Giannini Caterina , Nakazato Yoichi , Saito Nobuhito , Matsutani Masao , Nishikawa Ryo , Daniels David J. , Ichimura Koichi 
Published: March 2023

AbstractTumor markers in CNS germ cell tumors (GCTs) include human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP), which have significant diagnostic implications, as elevation of either one leads to clinical diagnosis of non-germinomatous GCTs without histopathological confirmation, justifying intensified chemotherapy and irradiation. The current study, based on an international cohort of histopathologically verified GCTs that underwent biopsy (n = 85) or resection (n = 76), sought to better define the clinical role and prognostic significance of tumor markers from serum and CSF in this challenging patient population. We found that HCG was elevated only in cases with a germinoma or choriocarcinoma component, and there existed a clear cut-off HCG value between the two. AFP was often elevated in GCTs without a yolk sac tumor component, especially immature teratoma. HCG was elevated only in CSF in 3-of-52 cases, and AFP was elevated only in serum in 7-of-49 cases, emphasizing the potential utilization of both serum and CSF studies. Immature teratoma demonstrated unfavorable prognosis independent of tumor marker status, with 56% 5-year overall survival; however, co-existent germinoma components indicated a more favorable prognosis. Taken together, the study findings emphasize the importance for routine assessment and guarded interpretation of tumor markers in CNS GCTs.
Kernel regression for errors-in-variables problems in the circular domain
Authors: Di Marzio Marco , Fensore Stefania , Taylor Charles C. 
Published: March 2023

AbstractWe study the problem of estimating a regression function when the predictor and/or the response are circular random variables in the presence of measurement errors. We propose estimators whose weight functions are deconvolution kernels defined according to the nature of the involved variables. We derive the asymptotic properties of the proposed estimators and consider possible generalizations and extensions. We provide some simulation results and a real data case study to illustrate and compare the proposed methods.
Sequencing Targeted and Immune Therapy in BRAF-Mutant Melanoma: Lessons Learned
Authors: Trojaniello Claudia , Sparano Francesca , Cioli Eleonora , Ascierto Paolo Antonio 
Published: March 2023

Abstract
Purpose of Review
The treatment strategy for BRAF-mutated melanoma remains unsatisfactory, although the advent of immune checkpoint inhibition has improved the prognosis of advanced melanoma. This article reports current evidence on the efficacy and safety of sequential immunotherapy with targeted therapy in patients with BRAF-mutated melanoma. It discusses criteria for the use of available options in clinical practice.

Recent Findings
Targeted therapy provides rapid disease control in a relatively high proportion of patients, although the development of secondary resistance limits the duration of responses; in contrast, immunotherapy may induce slow but more durable responses in a subset of patients.

Summary
Therefore, the identification of a combination strategy for the use of these therapies seems a promising perspective. Currently, inconsistent data have been obtained, but most studies indicate that the administration of BRAFi/MEKi prior to immune checkpoint inhibitors appears to reduce the efficacy of immunotherapy. On the contrary, several clinical and real-life studies suggest that frontline immunotherapy with subsequent targeted therapy may be associated with better tumor control than immunotherapy alone. Larger clinical studies are ongoing to confirm the efficacy and safety of this sequencing strategy for treating BRAF-mutated melanoma with immunotherapy followed by targeted therapy.
7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
Authors: Ju Won Seok , Seo Sang Young , Mun Seong-eun , Kim Kyongtae , Yu Jin Ok , Ryu Jae-Sung , Kim Ji-Su , Choo Young-Kug 
Published: March 2023

AbstractMalignant melanoma is a skin cancer with poor prognosis and high resistance to conventional treatment. 7,8-dihydroxyflavone (7,8-DHF) has shown anti-carcinogenic, anti-inflammatory, anti-oxidant, and pharmacological effects in several types of cancer. However, the relationship between ganglioside expression and the anti-cancer effects of 7,8-DHF in melanoma is not fully understood. In the present study, 7,8-DHF exhibits specific anti-proliferation, anti-migration, and G2/M phase cell-cycle arrest effects on both melanoma cancer cell lines, and induces mitochondrial dysfunction and apoptosis, making it a potent candidate for anti-melanoma treatment. Furthermore, we confirmed that 7,8-DHF significantly reduces the expression levels of ganglioside GD3 and its synthase, which are known to be closely involved in carcinogenesis. Taken together, our findings suggest that 7,8-DHF may be a potent anti-cancer drug candidate for the treatment of malignant melanoma.
The Influence of Focused Attention and Open Monitoring Mindfulness Meditation States on True and False Memory
Authors: Bitton Sara , Chatburn Alex , Immink Maarten A. 
Published: March 2023

AbstractPrevious investigations into the effect of mindfulness meditation on false memory have reported mixed findings. One potential issue is that mindfulness meditation involves different styles that establish distinct cognitive control states. The present work aimed to address this issue by comparing the effects of single-session focused attention (FAM) and open monitoring (OMM) mindfulness meditation styles on true and false memory recall. Strengthened cognitive control states associated with FAM were predicted to increase true memory recall and decrease false memory recall. Conversely, weakened cognitive control established by OMM was predicted to increase false memory recall. Thirty-four meditation-naïve participants (23 females, mean age = 23.4 years, range = 18–33) first completed pre-meditation learning and recall phases of the Deese-Roediger-McDermott (DRM) task. Participants then completed a single session of FAM or OMM prior to a second, post-meditation, round of DRM task learning and recall phases with a novel word list. Finally, participants completed a recognition test with true and false memory, and distractor words. Both FAM and OMM groups demonstrated significant increase in false memory recall between pre- and post-meditation recall tests but these groups did not differ with respect to true and false memory recall and recognition. The present findings are consistent with previous reports of increased false memory arising from mindfulness meditation. Distinct cognitive control states associated with FAM and OMM states do not result in distinct true and false memory formation, at least in meditation-naïve adults.
Policing the Delinquent Child in Ghana: Talk or Action?
Authors: Marfo Samuel , Musah Halidu , Bamora Florence Naah , Aniagyei Wilson 
Published: March 2023

AbstractIn Ghana, persons below 18 years of age are presumed to be children and vulnerable, and are expected to enjoy special protection and care against all hazards, even if they go against the law. This agrees with Ghana’s legal provision and other international legal documents. This study examined the knowledge of the police and their relationship with children in conflict with the law in Ghana using the Northern Region as a case study. Primary data were generated through interviews and questionnaire administration from a combined 219 participants who were purposely and systematically selected in a convergent mixed-methods design. The study found good knowledge of the police as to who a child in conflict with the law was (76%), yet only 40% rightly knew the criminal capacity of a child. The study revealed that the rights of children in conflict with the law, such as non-torture, access to legal assistance and right to safe custody, were flouted.
Effectiveness and cost of a rapid response campaign against Japanese knotweed (Reynoutria japonica) along a Canadian river
Authors: Rouleau Gabriel , Bouchard Marianne , Matte Rébecca , Lavoie Claude 
Published: March 2023

AbstractJapanese knotweed (Reynoutria japonicaHoutt.) is an invasive Asian plant abundant along rivers in its introduced range. In riparian areas, floods and ice flows uproot the rhizomes, facilitating their dissemination downstream. Control of large, well-establishedR. japonicaclones in riparian areas is difficult if the use of herbicides is prohibited. An alternative to controlling entrenched clones is the rapid detection and manual unearthing of rhizome fragments that have recently rooted after being deposited by floodwaters. We applied this strategy along a Canadian river where spring floods with abundant ice are recurrent. Two river stretches, with approximately 10 km of shoreline each, were selected for the fragment removal campaign. One of the stretches was heavily invaded byR. japonica, while the other was only sparsely invaded. In the heavily invaded stretch, 1,550 and 737R. japonicarhizome fragments were unearthed in 2019 and 2020, respectively. Unearthed fragments had an average length of 27 to 32 cm. Only 21 fragments were found in the sparsely invaded stretch in 2020. Despite similar distances being surveyed, the detection and unearthing took 62% less time (overall) in the sparsely invaded than in the heavily invaded stretch. Along sparsely invaded riverbanks, a rapid response removal campaign forR. japonicacost, including transportation and labor, an estimated Can$142 (US$105) per aborted clone (i.e., fragment removed). A rapid response removal campaign is economically advantageous compared with the hypothetical eradication of large, well-established clones, but for it to be cost-effective, the time spent locating rhizome fragments must exceed the time spent unearthing them. The question is not whether rapid response unearthing is economically feasible—it is—but rather what invasion level renders the intervention practicable. In highly invaded river stretches generating thousands of fragments annually, finding and removing these fragments year after year would require a massive, unsustainable effort.
The role of organisational factors and environmental conditions on the success of newly founded firms
Authors: Fuertes-Callén Yolanda , Cuellar-Fernández Beatriz , Serrano-Cinca Carlos 
Published: March 2023

AbstractThis study examines the influence of founding conditions and decisions on new companies' performance, analysing how both environmental context and organisational dynamics interact to determine their success. It distinguishes between two different success indicators: survival and profitable growth. An empirical study conducted using a sample of 3,722 new agri-food companies in two different periods, one of economic stability and the other of recession, showed that founding conditions had long-lasting effects on post-entry performance. The economic context acted as a moderator of the relationship between individual factors and success. Adverse environmental conditions were also a determinant of success, making surviving firms more competitive and resilient. The results reflect the survival of the fitter principle by showing that early profitability reduced the risk of failure and made firms more likely to become profitable in the medium term. Internationalisation strategies developed organisational capabilities that created an imprint for adaptability and growth.
Rebecca Jackson and the Problem of Celibacy
Authors: Trollinger Rebekah 
Published: March 2023

AbstractThis paper examines the writings of Black Shaker visionary Rebecca Jackson, who was active in the middle of the nineteenth century. Jackson's accounts of her dreams, visions, and theology repeatedly demonstrate her deep commitment to celibacy and to obedience to God. Recent work on Jackson reads her celibacy as an example of defiance of white heteropatriarchy; this article suggests that reading her celibacy as disruptive flattens the most animating question in her life: How might I best serve God? Using Jackson's writings, including substantial descriptions of visions and dreams, I argue that her celibacy is a piece of her larger obedience to God, obedience that provides protection and fulfillment. Further, Jackson uses explicitly antiflesh theology to first re-center women in the Biblical story of redemption, and second, serve as the basis for her critique of gendered and racialized violence. Finally, Jackson's celibacy undergirds an understanding of pleasure that blurs the lines between the physical and spiritual, and that, for Jackson, makes possible earthly freedom and spiritual joy.
TORTURE, TRUTH AND NATIONAL SECURITY IN SENECA'S TROADES
Authors: Payne Matthew F. 
Published: March 2023

AbstractThis article argues that the encounter between Andromache and Ulysses in Seneca's Troades engages with the genre of declamation to juxtapose two different discourses surrounding torture: one focussed on torture's connection to truth, the other on its connection to tyranny. It describes how the Greek general Ulysses, convinced of the danger of letting the Trojan prince Astyanax live, threatens his mother Andromache with physical torture in order to ascertain the truth of Astyanax's whereabouts. However, Ulysses is countered by Andromache's rhetoric, through which, the article shows, she depicts herself as the archetypal heroic victim of a tyrant. It discusses how Ulysses innovates with an effective psychological torture in response. The article sets the scenario within the broader rhetorical context and demonstrates how it reflects debate among the contemporary elite about the necessity of, and the risks from, the rising use of torture by the Julio-Claudian emperors, a debate which resonates in the modern era.