bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transition‐metal‐free Cyclization of Mucohalic Acids with Sulfonyl Hydrazides: An Approach to Pyridazin‐3(2H)‐ones
Authors: Chen Qi , Li Huan‐Qing , Yang Kai , Xu Wen‐Jin , Zeng Yu , Wang Zhao‐Yang 
Published: September 2023

AbstractAn eco‐friendly and efficient synthesis of pyridazin‐3(2H)‐ones from aromatic sulfonyl hydrazides and mucohalic acids has been developed. This facile strategy is carried out smoothly via the promotion of simple organic acid p‐toluenesulfonic acid, and able to form two C−N bonds and a heterocycle linking a potentially bioactive sulfonyl group at one‐step. The protocol is tolerant to various readily available substrates in good yields, and pyridazin‐3(2H)‐ones as the desired products are key structural fragments of many bioactive compounds. More importantly, the gram‐scale cyclization reaction of aromatic sulfonyl hydrazides and mucohalic acids as a novel approach to pyridazin‐3(2H)‐ones derivatives successfully reveals its practicability.
High‐Frequency Gravitational Waves in Electromagnetic Waveguides
Authors: Sorge Francesco 
Published: September 2023

AbstractThe interaction between a very‐high‐frequency gravitational wave (VHFGW) and an electromagnetic wave (EMW) in a rectangular waveguide is discussed in the weak field limit. The background EMW is assumed to be initially in the TE10 mode along the waveguide. It is then shown that a VHFGW, having the same frequency and direction of propagation of the EMW, induces through the waveguide a TE mode with a frequency doubled when compared to the original EMW frequency. In that respect, the GW acts similar to a non‐linear medium, giving rise to a Second Harmonic Generation (SHG) effect.
Engineering Nucleotidoproteins for Base‐Pairing‐Assisted Cytosolic Delivery and Genome Editing
Authors: Liu Xun , Zhao Ziyin , Li Wei , Li Yajie , Yang Qiang , Liu Ningyu , Chen Yongbing , Yin Lichen 
Published: September 2023

AbstractProtein therapeutics targeting intracellular machineries hold profound potential for disease treatment, and hence robust cytosolic protein delivery technologies are imperatively demanded. Inspired by the super‐negatively charged, nucleotide‐enriched structure of nucleic acids, adenylated pro‐proteins (A‐proteins) with dramatically enhanced negative surface charges have been engineered for the first time via facile green synthesis. Then, thymidine‐modified polyethyleneimine is developed, which exhibits strong electrostatic attraction, complementary base pairing, and hydrophobic interaction with A‐proteins to form salt‐resistant nanocomplexes with robust cytosolic delivery efficiencies. The acidic endolysosomal environment enables traceless restoration of the A‐proteins and consequently promotes the intracellular release of the native proteins. This strategy shows high efficiency and universality for a variety of proteins with different molecular weights and isoelectric points in mammalian cells. Moreover, it enables highly efficient delivery of CRISPR‐Cas9 ribonucleoproteins targeting fusion oncogene EWSR1‐FLI1, leading to pronounced anti‐tumor efficacy against Ewing sarcoma. This study provides a potent and versatile platform for cytosolic protein delivery and gene editing, and may benefit the development of protein pharmaceuticals.
Integrated Tandem Electrochemical‐chemical‐electrochemical Coupling of Biomass and Nitrate to Sustainable Alanine
Authors: Wu Jingcheng , Xu Leitao , Kong Zhijie , Gu Kaizhi , Lu Yuxuan , Wu Xianwen , Zou Yuqin , Wang Shuangyin 
Published: September 2023

AbstractAlanine is widely employed for synthesizing polymers, pharmaceuticals, and agrochemicals. Electrocatalytic coupling of biomass molecules and waste nitrate is attractive for the nitrate removal and alanine production under ambient conditions. However, the reaction efficiency is relatively low due to the activation of the stable substrates, and the coupling of two reactive intermediates remains challenging. Herein, we realize the integrated tandem electrochemical‐chemical‐electochemical synthesis of alanine from the biomass‐derived pyruvic acid (PA) and waste nitrate (NO3−) catalyzed by PdCu nano‐bead‐wires (PdCu NBWs). The overall reaction pathway is demonstrated as a multiple‐step catalytic cascade process via coupling the reactive intermediates NH2OH and PA on the catalyst surface. Interestingly, in this integrated tandem electrochemical‐chemical‐electrochemical catalytic cascade process, Cu facilitates the electrochemical reduction of nitrate to NH2OH intermediates, which chemically couple with PA to form the pyruvic oxime, and Pd promotes the electrochemical reduction of pyruvic oxime to the desirable alanine. This work provides a green strategy to convert waste NO3− to wealth and enriches the substrate scope of renewable biomass feedstocks to produce high‐value amino acids.
A Bismuth‐Based Zeolitic Organic Framework with Coordination‐Linked Metal Cages for Efficient Electrocatalytic CO2 Reduction to HCOOH
Authors: Jiang Zhiqiang , Zhang Minyi , Chen Xingliang , Wang Bing , Fan Wenjuan , Yang Chenhuai , Yang Xiaoju , Zhang Zhicheng , Yang Xuan , Li Chunsen , Zhou Tianhua 
Published: September 2023

AbstractZeolitic metal–organic frameworks (ZMOFs) have emerged as one of the most promsing catalysts for energy conversion, but they suffer from either weak bonding between metal‐organic cubes (MOCs) that decrease their stability during catalysis processes or low activity due to inadequate active sites. In this work, through ligand‐directing strategy, we successfully obtain an unprecedented bismuth‐based ZMOF (Bi‐ZMOF) featuring a ACO topological crystal structure with strong coordination bonding between the Bi‐based cages. As a result, it enables efficient reduction of CO2 to formic acid (HCOOH) with Faradaic efficiency as high as 91 %. A combination of in situ surface‐enhanced infrared absorption spectroscopy and density functional theory calculation reveals that the Bi−N coordination contributes to facilitating charge transfer from N to Bi atoms, which stabilize the intermediate to boost the reduction efficiency of CO2 to HCOOH. This finding highlights the importance of the coordination environment of metal active sites on electrocatalytic CO2 reduction. We believe that this work will offer a new clue to rationally design zeolitic MOFs for catalytic reaction
Photo‐thermal Cooperative Carbonylation of Ethanol with CO2 on Cu2O‐SrTiCuO3‐x
Authors: Zhang Jian , Shang Chuanbao , An Zhe , Zhu Yanru , Song Hongyan , Chai Zhigang , Shu Xin , Zheng Lirong , He Jing 
Published: September 2023

AbstractCarbonylation of ethanol with CO2 as carbonyl source into value‐added esters is of considerable significance and interest, while remains of great challenge due to the harsh conditions for activation of inert CO2 in that the harsh conditions result in undesired activation of α‐C−H and even cleavage of C−C bond in ethanol to deteriorate the specific activation of O−H bond. Herein, we propose a photo‐thermal cooperative strategy for carbonylation of ethanol with CO2, in which CO2 is activated to reactive CO via photo‐catalysis with the assistance of *H from thermally‐catalyzed dissociation of alcoholic O−H bond. To achieve this proposal, an interfacial site and oxygen vacancy both abundant SrTiCuO3‐x supported Cu2O (Cu2O‐SrTiCuO3‐x) has been designed. A production of up to 320 μmol g−1 h−1 for ethyl formate with a selectivity of 85.6 % to targeted alcoholic O−H activation has been afforded in photo‐thermal assisted gas‐solid process under 3.29 W cm−1 of UV/Vis light irradiation (144 °C) and 0.2 MPa CO2. In the photo‐driven activation of CO2 and following carbonylation, CO2 activation energy decreases to 12.6 kJ mol−1, and the cleavage of alcoholic α‐C−H bond has been suppressed.
Metal‐Free Stereoconvergent C−H Borylation of Enamides
Authors: Wang Tianhang , Wang Zheng‐Jun , Wang Minyan , Wu Lei , Fang Xiaowu , Liang Yong , Lv Jiahang , Shi Zhuangzhi 
Published: September 2023

AbstractEnamides, functional derivatives of enamines, play a significant role as synthetic targets. However, the stereoselective synthesis of these molecules has posed a longstanding challenge in organic chemistry, particularly for acyclic enamides that are less thermodynamically stable. In this study, we present a general strategy for constructing β‐borylenamides by C−H borylation, which provides a versatile platform for generating the stereodefined enamides. Our approach involves the utilization of metalloid borenium cation, generated through the reaction of BBr3 and enamides in the presence of two different additives, avoiding any exogenous catalyst. Importantly, the stereoconvergent nature of this methodology allows for the use of starting materials with mixed E/Z configurations, thus highlighting the unique advantage of this chemistry. Mechanistic investigations have shed light on the pivotal roles played by the two additives, the reactive boron species, and the phenomenon of stereoconvergence.
Metastable biological matter in liquid phase separation
Authors: Liu Jianhui , Liu Xiaolin , Zhang Tianfu , Huang Jinqing , Tang Ben Zhong , Chau Ying 
Published: September 2023

AbstractMembraneless organelles (MLOs) are likely assembled via liquid–liquid phase separation (LLPS). The liquid‐like MLOs afford multifold peculiarities including high dynamics, reversibility and responsiveness. It is common to see fast, drastic, and reversible formation and dissolution events of MLOs, as well as transition into more stable glassy or gel‐like states, which suggests a metastable assembly state. Moreover, the alteration of metastability of LLPS is linked with cellular pathology. Here, we review the “metastability” related to MLOs driven by liquid phase separation, from multifaceted regards including energy state, molecular interactions, molecular structure, phase transition, as well as the associations with diseases. This review can help to advance the insight into properties and pathogenesis associated with LLPS of biological matter.
Hintergründe und Nachweisgrundlagen zur Brandschutzbemessung von Brettsperrholzkonstruktionen – Teil 2
Authors: Werther Norman , Schmid Joachim , Fahrni Reto , Klippel Michael 
Published: September 2023

AbstractIm Rahmen dieses zweiteiligen Beitrags wird auf die brandschutztechnische Bemessung für Brettsperrholzelemente und ‐konstruktionen eingegangen und deren Besonderheit im Vergleich zu Voll‐ und Brettschichtholz aufgezeigt. Der zweite Teil erläutert die Nachweisansätze der raumabschließenden Funktion von bekleideten und unbekleideten Brettsperrholzbauteilen, stellt die Prinzipien zur brandschutztechnisch sicheren Detailausbildung dar und gibt Erläuterungen zum Einfluss von Brettsperrholz auf die Branddynamik.
Quiet eye training–based intervention can ameliorate inhibitory control but not visuospatial working memory in children with ADHD
Authors: Psotta Rudolf , Sarvestan Javad , Valtr Ludvík , Ješina Ondrej 
Published: September 2023

AbstractIntroThe purpose of this study was to investigate the effects of quiet eye training (QET) on inhibitory control, visuospatial working memory (WM), and tonic attention in children with attention‐deficit hyperactivity disorder (ADHD).MethodsForty‐eight children with ADHD aged 9–12 years were randomly assigned to QET and control (CON) groups. The QET group practiced targeted hand–eye tasks within a QET protocol developed to optimize controlled attention and gaze through eye fixations. We used the go/no‐go (GNG) test, the Corsi test, and the reaction test of alertness (RTA) to verify the effects of QET on inhibition control, WM, and tonic attention.ResultsQET group showed significantly shorter reaction times, a higher number of correct responses, and a lower number of omissions in the GNG inhibition test after QET as compared to the pre‐measurements, whereas the CON group did not demonstrate significant changes in this test. The measures of WM (Corsi test) and tonic attention (RTA) did not change significantly with the QET‐based intervention.ConclusionThe study demonstrated that the QET protocol, which includes instructions and a video demonstration to optimize eye fixation on a target during aiming tasks, is acceptable and usable for children with ADHD. Overall, a short‐term, 5‐week visuomotor training intervention based on the quiet eye paradigm was shown to be effective in improving inhibitory control and focused visual attention, but not visuospatial WM and intrinsic attention in 9–12‐year‐old children with inattentive or combined ADHD.
Prominent cerebral veins on susceptibility‐weighted angiography in acute meningoencephalitis
Authors: Jung Yo Han , Park Mina , Joo Bio , Suh Sang Hyun , Lee Kyung‐Yul , Ahn Sung Jun 
Published: September 2023

AbstractBackground and purposeWe have commonly observed prominent cerebral veins on susceptibility‐weighted angiography (SWAN) in acute meningoencephalitis. This study aimed to investigate the clinical significance of these findings.MethodsCerebral veins on SWAN of 98 patients with acute meningoencephalitis diagnosed from February 2016 through October 2020 were classified into three groups according to the degree of venous prominence (mild, 23; moderate, 53; and prominent, 22). Clinical variables and laboratory findings were compared between these groups. The influence of variables on the prediction of prominent cerebral veins was measured by random forest (RF) and gradient boosting machine (GBM).ResultsAs cerebral veins became more prominent, cerebrospinal fluid (CSF) glucose level decreased (69.61 ± 29.05 vs. 59.72 ± 22.57 vs. 48.36 ± 20.29 mg/dL, p = .01) and CSF protein level increased (100.73 ± 82.98 vs. 104.73 ± 70.99 vs. 159.12 ± 118.15 mg/dL, p = .03). The etiology of meningoencephalitis, neurological symptoms, and increased intracranial pressure (ICP) signs differed between groups (p < .05). RF and GBM demonstrated that CSF protein level was the variable with the highest power to predict the prominent cerebral vein (mean decrease in node impurity: 4.19, relative influence: 50.66).ConclusionThe presence of prominent cerebral veins on SWAN in acute meningoencephalitis was significantly associated with a low CSF glucose level and a high CSF protein level, as well as ICP. Thus, the visual grade of the cerebral veins on SWAN may be utilized for the management of patients with acute meningoencephalitis.
Intratumoral nanofluidic system enhanced tumor biodistribution of PD‐L1 antibody in triple‐negative breast cancer
Authors: Liu Hsuan‐Chen , Capuani Simone , Badachhape Andrew A. , Di Trani Nicola , Davila Gonzalez Daniel , Vander Pol Robin S. , Viswanath Dixita I. , Saunders Shani , Hernandez Nathanael , Ghaghada Ketan B. , Chen Shu‐Hsia , Nance Elizabeth , Annapragada Ananth V. , Chua Corrine Ying Xuan , Grattoni Alessandro 
Published: September 2023

AbstractImmune checkpoint inhibitors (ICI), pembrolizumab and atezolizumab, were recently approved for treatment‐refractory triple‐negative breast cancer (TNBC), where those with Programmed death‐ligand 1 (PD‐L1) positive early‐stage disease had improved responses. ICIs are administered systemically in the clinic, however, reaching effective therapeutic dosing is challenging due to severe off‐tumor toxicities. As such, intratumoral (IT) injection is increasingly investigated as an alternative delivery approach. However, repeated administration, which sometimes is invasive, is required due to rapid drug clearance from the tumor caused by increased interstitial fluid pressure. To minimize off‐target drug biodistribution, we developed the nanofluidic drug‐eluting seed (NDES) platform for sustained intratumoral release of therapeutic via molecular diffusion. Here we compared drug biodistribution between the NDES, intraperitoneal (IP) and intratumoral (IT) injection using fluorescently labeled PD‐L1 monoclonal antibody (αPD‐L1). We used two syngeneic TNBC murine models, EMT6 and 4T1, that differ in PD‐L1 expression, immunogenicity, and transport phenotype. We investigated on‐target (tumor) and off‐target distribution using different treatment approaches. As radiotherapy is increasingly used in combination with immunotherapy, we sought to investigate its effect on αPD‐L1 tumor accumulation and systemic distribution. The NDES‐treated cohort displayed sustained levels of αPD‐L1 in the tumor over the study period of 14 days with significantly lower off‐target organ distribution, compared to the IP or IT injection. However, we observed differences in the biodistribution of αPD‐L1 across tumor models and with radiation pretreatment. Thus, we sought to extensively characterize the tumor properties via histological analysis, diffusion evaluation and nanoparticles contrast‐enhanced CT. Overall, we demonstrate that ICI delivery via NDES is an effective method for sustained on‐target tumor delivery across tumor models and combination treatments.
Essential Oils from Different Parts of Magnolia laevifolia: Chemical Constituents and Insecticidal Activities against Liposcelis bostrychophila
Authors: Zhang Jia‐Wei , Feng Yi.‐Xi , Zheng Yu , Wang Cheng‐Fang , Du Shu‐Shan 
Published: September 2023

AbstractMany synthetic pesticides were used to control a severe storage pest, booklouse (Liposcelis bostrychophila). However, considering the environmental impact, plant secondary metabolites were acceptable alternatives. An endemic plant, Magnolia laevifolia, has a significant and unique odour, so its essential oil (EO) could be an option for bio‐pesticide development. This study extracted EOs from leaves, flowers, carpels and seeds of M. laevifolia. The common and major compound of EOs was isocapnell‐9‐en‐8‐one, which was present at 17.7 to 91.6 % in these four parts. We found no regular pattern in the composition of EO in terms of parts and collection time according to principal component analysis. The contact and repellent activities of EOs against the booklouse were then conducted. Leaves and flowers’ EOs collected in the flowering stage had the best contact toxicity. The percent repellency values of the EOs from different parts of M. laevifolia reached above 80 % after 2 and 4 h exposure at 63.17 nL/cm2, with the same levels as DEET (p<0.05). It was shown that parts of plants and collecting time could influence the insecticidal activities of M. laevifolia EOs against booklouse, but collecting time played a significant decisive role in the contact test.
Carbon Dioxide Hydrogenation to Formate Catalyzed by a Neutral, Coordinatively Saturated Tris‐Carbonyl Mn(I)‐PNP Pincer‐Type Complex
Authors: Kostera Sylwia , Manca Gabriele , Gonsalvi Luca 
Published: September 2023

AbstractCO2 catalytic hydrogenation to formate was achieved (TONmax=ca. 3800) in the presence of the neutral, halide‐free, coordinatively saturated tris(carbonyl) manganese pincer‐type complex [Mn(PNP)(CO)3], bearing a diarylamido pincer‐type PNP ligand, using DBU as base and LiOTf as Lewis acid additive, under mild reaction conditions (60 bar, 80 °C). DFT calculations suggest that the precatalyst activation key step occurs by intermolecular, base assisted dihydrogen heterolytic splitting rather than by the expected ligand‐assisted intramolecular MLC‐type mechanism.
Pharmacokinetic and Bioequivalence Study of Lisinopril/Hydrochlorothiazide Tablet Under Fasting and Postprandial Conditions in Healthy Chinese Subjects
Authors: Yang Zhuan , Mi Xiaolan , Li Qin , Chen Lu , Zeng Yan , Du Peng , Liu Lin , Liu Shijing , Zeng Chen , Zhang Qian , Zhou Yan , Xiong Yun , Li Na , Ze Qiuyuan , Chen Jiyu , He Yan 
Published: September 2023

AbstractThe objective of this research was to evaluate and compare the pharmacokinetic profiles and safety of lisinopril/hydrochlorothiazide (10 mg/12.5 mg) tablets in the test and reference formulations administered to participants in both fasting and postprandial states and to evaluate the bioequivalence of the 2 products in healthy Chinese volunteers. This study employed a single‐center, randomized, open‐label, single‐dose dosing trial involving a cumulative 96 healthy adult participants (60 in the fasting group and 36 in the postprandial group). Each group comprised 2 sequence sets, and a 2‐week washout period was implemented. There were no statistically significant differences in time to maximum concentration and terminal elimination half‐life between the test and control groups under fasting and postprandial conditions (P > .05), and the 90% CIs for area under the plasma concentration–time curve and maximum plasma concentration were within the bioequivalence range of 80%‐125%. Pharmacokinetic results indicate a large food effect for lisinopril, meaning that there is a loss of approximately 20%‐25% of systemic exposure from fasting to postprandial administration for both preparations. The study demonstrated that a single oral dose of generic lisinopril/hydrochlorothiazide is bioequivalent to the reference product and well tolerated, with no significant adverse events observed, and that both products are similarly safe in a cohort of healthy Chinese male and female participants, following administration under fasting and postprandial conditions.
Characterization and Comparative Study of Energy Efficient Mechanochemically Induced NASICON Sodium Solid Electrolyte Synthesis
Authors: Gebi Asma'u I. , Dolokto Oleksandr , Mereacre Liuda , Geckle Udo , Radinger Hannes , Knapp Michael , Ehrenberg Helmut 
Published: September 2023

AbstractIn recent years, there is growing interest in solid‐state electrolytes due to their many promising properties, making them key to the future of battery technology. This future depends among other things on easy processing technologies for the solid electrolyte. The sodium superionic conductor (NASICON) Na3Zr2Si2PO12 is a promising sodium solid electrolyte; however, reported methods of synthesis are time consuming. To this effect, attempt was made to develop a simple time efficient alternative processing route. Firstly, a comparative study between a new method and commonly reported methods was carried out to gain a clear insight into the mechanism of formation of sodium superionic conductors (NASICON). It was observed that through a careful selection of precursors, and the use of high‐energy milling (HEM) the NASICON conversion process was enhanced and optimized, this reduces the processing time and required energy, opening up a new alternative route for synthesis. The obtained solid electrolyte was stable during Na cycling vs. Na‐metal at 1 mA cm−1, and a room temperature conductivity of 1.8 mS cm−1 was attained.
Functional Polymers as Artificial Solid Electrolyte Interfaces for Stabilizing Lithium Metal Anode
Authors: Naren Tuoya , Jiang Ruheng , Kuang Gui‐chao , Zhou Liangjun , Chen Libao 
Published: September 2023

AbstractThe practical implementation of the lithium metal anode (LMA) has long been pursued due to its extremely high specific capacity and low electrochemical equilibrium potential. However, the unstable interfaces resulting from lithium ultrahigh reactivity have significantly hindered the use of LMA. This instability directly leads to dendrite growth behavior, dead lithium, low Coulombic efficiency, and even safety concerns. Therefore, artificial solid electrolyte interfaces (ASEI) with enhanced physicochemical and electrochemistry properties have been explored to stabilize LMA. Polymer materials, with their flexible structures and multiple functional groups, offer a promising way for structurally designing ASEIs to address the challenges faced by LMA. This Concept demonstrates an overview of polymer ASEIs with different functionalities, such as providing uniform lithium ion and single‐ion transportation, inhibiting side reactions, possessing self‐healing ability, and improving air stability. Furthermore, challenges and prospects for the future application of polymeric ASEIs in commercial lithium metal batteries (LMBs) are also discussed.