bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modern approaches to the development of artistic actions in opera and vocal performance
Authors: Nikolaenko Volodymyr 
Published: June 2023

Purpose of the article. To reveal the specifics of physicality as an important component of artistic skill and to determine promising approaches to the development of artistic actions at the present stage of professional training of opera singers. The research methodology consists of the use of typological, structural-typological, and comparative methods to study modern approaches to the development of artistic actions in opera and vocal performance, the relationship between body movement and sound movement, and six types of intellectual skills that an opera singer should have are analyzed. Research novelty. The specificity of opera and vocal performance in the context of the development of artistic corporality as an important component of professional skill and the definition of the latest methods and approaches in the stage creativity of an opera singer is considered. Conclusions. Based on the study of the process of the development of the bodily expression of an opera singer, it was found that the problem lies in the disharmony between vocal performance and physical movements in the process of solo singing. It is noted that the relationship between different fields of art - dance, music, theater, and somatic therapy should complement each other in favor of a common goal - training that unites voice, body, lyrics, and music. Modern curricula for the preparation of opera singers should include exercises developed from theatrical technique, somatic therapy, and dance practice, taking into account the latest research in neurobiology. In our opinion, they will help a better understanding of the body and the relationship between body and sound, and expand the artistic and expressive abilities of the future opera artist.
Key words: opera and vocal performance, artistic actions, professional training, corporality, neurobiology, muscles.
Pemberdayaan Kader Kesehatan dalam Upaya Deteksi Dini Stroke dengan Metode F.A.S.T di Kecamatan Tugu
Authors: Prihati Dyah Restuning , Prasetyorini Heny 
Published: June 2023

ABSTRAK Stroke adalah penyakit yang menyerang sistem saraf manusia yang sangat mengancam jiwa. Penyakit ini menjadi masalah kesehatan yang dapat kecacatan. Golden time pasien stroke terutama stroke iskemik adalah 3 jam setelah stroke. Salah satu upaya yang berperan penting untuk mencapai tujuan tersebut adalah pengenalan gejala-gejala stroke dan penanganan stroke secara dini yang dimulai dari penanganan prahospital yang cepat dan tepat. Kegiatan pengabdian masyarakat diberikan kepada kelompok kader kesehatan di wilayah kecamatan Tugu, diharapkan mereka mampu mengaplikasikan deteksi dini dan pencegahan stroke dengan metode F.A.S.T. Pengukuran tekanan darah, pemberian materi tentang deteksi dini Metode F.A.S.T dan pencegahan stroke, demonstrasi senam pencegahan stroke dan pendampingan. Evaluasi kegiatan dilakukan dengan memberikan kuisioner pengetahuan tentang deteksi dini dan pencegahan stroke. Terjadi peningkatan pengetahuan sebanyak 90% peserta setelah dilakukan edukasi tentang deteksi dini Metode F.A.S.T dan pencegahan stroke. Peserta kooperatif selama mengikuti kegiatan PKM. Pembuatan luaran meliputi publikasi jurnal, publikasi di media online dan HKI poster. Edukasi tentang deteksi dini dan pencegahan stroke dapat meningkatkan pengetahuan kader, agar menggerakkan masyarakat dalam upaya pencegahan stroke. Kata Kunci: Deteksi Dini Metode FAST, Kader Kesehatan, Stroke ABSTRACT Introduction: Stroke is a disease that attacks the human nervous system and is very life-threatening. This disease is a health problem that can be disabled. The golden time for stroke patients, especially ischemic stroke, is 3 hours after stroke. One of the efforts that play an important role in achieving this goal is the recognition of stroke symptoms and early treatment of stroke starting with prehospital treatment that is fast and appropriate. Purpose: Community service activities are given to groups of health cadres in the Tugu sub-district, it is hoped that they will be able to apply the early detection and prevention of stroke using the F.A.S.T method. Methods: Measuring blood pressure, providing material on early detection of the F.A.S.T Method and stroke prevention, demonstrating stroke prevention exercise and mentoring. Evaluation of activities is carried out by providing knowledge questionnaires about the early detection and prevention of stroke. Result: there was an increase in knowledge of 90% of participants after education about the F.A.S.T Method's early detection and stroke prevention. Cooperative participants during the PKM activities. Production of outputs includes publications in journals, publications in online media, and HKI posters. Conclusion: Education about early detection and prevention of stroke can increase the knowledge of cadres so that they can mobilize the community in stroke prevention efforts. Keywords: FAST Method Early Detection, Health Cadres, Stroke
Perbandingan Efektivitas dan Efek Samping Antivirus Favipiravir dan Remdesivir Pada Pasien COVID-19
Authors: Haqim Luqman Nul , Setiadi Antonoius Adji Prayitno 
Published: June 2023

ABSTRACT Coronavirus Disease-2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-Cov-2). Symptoms are divided into asymptomatic, mild, moderate, severe and critical. In patients with moderate symptoms, antiviral therapy is given, including favipiravir and remdesivir. This study aims to look at the effectiveness and side effects of the two drugs. This study was a cross-sectional study involving all COVID-19 patients with moderate symptoms who were treated at the Husada Utama Hospital in Surabaya from January to December 2021. Patient data was taken based on medical record data. Data analysis used univariate and bivariate techniques. There were 59 patients who met the inclusion and exclusion criteria. There were 32 patients using favipiravir and 27 patients using remdesivir. In this study, there were no significant differences regarding the effectiveness and side effects between the use of favipiravir and remdesivir. However, the use of favipiravir was significantly shorter than remdesivir (p = 0.015). The conclusion in this study was that there were no significant differences in terms of effectiveness and side effects between the use of favipiravir and remdesivir in patients with moderate symptoms of COVID-19. Keywords: Favipiravir, Remdesivir, COVID-19, Moderate Degree ABSTRAK Coronavirus Disease-2019 (COVID-19) merupakan penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrom Coronavirus-2 (SARS-Cov-2). Gejala yang ditimbulkan dibagi menjadi tanpa gejala, ringan, sedang, berat dan kritis. Pada pasien dengan gejala sedang terapi antivirus yang diberikan antara lain favipiravir dan remdesivir. Penelitian ini bertujuan untuk melihat efektivitas dan efek samping dari kedua obat tersebut. Penelitian ini merupakan penelitian cross sectional yang melibatkan seluruh pasien COVID-19 dengan gejala sedang yang dirawat di rumah sakit Husada Utama kota Surabaya pada periode Januari sampai dengan Desember 2021. Data pasien diambil berdasarkan data rekam medis. Analisis data menggunakan teknik univariat dan bivariat. Terdapat 59 pasien yang memenuhi kriteria inklusi dan eksklusi. Pasien yang menggunakan favipiravir sebanyak 32 pasien dan yang menggunakan remdesivir sebanyak 27 pasien. Dalam penelitian ini tidak terdapat perbedaan yang signifikan terkait efektivitas dan efek samping antara penggunaan favipiravir dan remdesivir. Namun penggunaan favipiravir secara signifikan lebih singkat dibandingkan remdesivir (p = 0,015). Kesimpulan dalam penelitian ini adalah tidak terdapat perbedaan yang signifikan terkait efektivitas dan efek samping antara penggunaan favipiravir dan remdesivir pada pasien COVID-19 gejala sedang. Kata Kunci: Favipiravir, Remdesivir, COVID-19, Derajat Sedang
Khamir Potensial Probiotik Hasil Isolasi dari Fermentasi Jus Jeruk Siam (Citrus nobilis var. microcarpa)
Authors: Lina Linawati , Rusmiyanto Elvi , Kurniatuhadi Rikhsan 
Published: June 2023

Jus jeruk siam (Citrus nobilis var. microcarpa) yang difermentasi merupakan minuman olahan yang mengandung nutrisi penunjang pertumbuhan dari khamir probiotik. Tujuan dari penelitian ini adalah untuk mengetahui potensial probiotik dari khamir dan mengetahui genus khamir probiotik yang diisolasi dari fermentasi jus jeruk siam. Kemampuan dari khamir probiotik diperoleh dengan melakukan pengujian ketahanan terhadap kondisi asam (pH rendah) dan uji daya hambat terhadap bakteri patogen Eschericia coli. Semua isolat khamir mampu tumbuh pada pH 2, 3 dan 4, pertumbuhan terbaik pada pH 4. Semua isolat khamir juga mampu menghambat pertumbuhan dari E. coli yang terlihat dari zona hambat yang terbentuk. Isolat khamir diidentifikasi berdasarkan pengamatan secara makroskopis koloni dan mikroskopis dari sel khamir, reproduksi sel, dan uji fisiologis. Berdasarkan hasil identifikasi diperoleh 6 isolat khamir probiotik yang menunjukkan genus Kluyveromyces, Pichia, dan Saccharomyces.
Abstract
Siam orange juice (Citrus nobilis var. microcarpa) fermented is a processed drink that contains nutrients that support the growth of probiotic yeast. The research aims to determine the probiotic potential of yeast and to determine the genus of probotic yeast isolated from fermented siam orange juice. The ability of probiotic yeast is obtained by testing the resistance towards acid conditions (pH) and testing the inhibitory against pathogenic bacteria Eschericia coli. All yeast isolates were able to grow at pH 2, 3 and 4, the best growth was at pH 4. All probiotic yeast isolates were also able to inhibit the growth of pathogenic bacteria E. coli as seen from the formed inhibition zone The yeast isolates were identified on colony macroscopic and microscopic observation of yeast cells, cell reproduction, physiological tests. The results of the isolation obtained 6 isolates that showed probiotic properties from the genera Kluyveromyces, Pichia, and Saccharomyces.
Strategi Komunikasi Radio Kharisma 95,6 FM Bengkulu Utara Dalam Meningkatkan eksistensi Sebagai Lembaga Penyiaran Publik Lokal Melalui Program Siaran “Sapa Pagi”
Authors: Aji Muhammad Rama , Supriyadi Dedy , Budiman Dwi Aji 
Published: June 2023

Penelitian ini menggunakan teknik analisis kualitatif deskriptif dan pengumpulan data yaitu dengan observasi, wawancara, dan dokumentasi, serta mencari referensi melalui buku, jurnal, skripsi dan artikel yang berhubungan dengan penelitian. Penelitian ini juga menggunakan teknik analisis data melalui pengumpulan data, reduksi data, display data, dan verifikasi dan penarikan kesimpulan. Teori yang digunakan dalam penelitian ini adalah teori Ekologi Media, dengan mengikuti pernyataan dari Dimmick dan Rohtenbuhler, yaitu ada tiga sumber utama dari penunjang hidup suatu media, yaitu types of content, types of audience, dan capital. Hasil dari penelitian ini adalah bahwa LPPL Radio Kharisma 95.6 FM Bengkulu Utara telah melakukan upaya dan memiliki strategi tersendiri yang telah mencakup 3 sumber media dalam bertahan hidup, yaitu memanfaatkan ruang komuikasi sebagai pengumpulan ide pendapat dengan semua pihak radio, kemudian menerapkan tekhnik komunikasi yaitu memperhatikan tempo dan intonasi, dan memanfaatkan dengan maksimal sumber dana operasional utama yaitu APBD lalu mengikut sertakan semua crew radio untuk mengikuti pelatihan untuk meningkatkan kualitas SDM.
Kata Kunci: Strategi Komunikasi, Radio, LPPL, Ekologi Media
Pengalaman Perempuan Setelah Perselingkuhan Pasangan, bertahan atau berpisah ?
Authors: - Indria , Anis Endang Anis Endang 
Published: June 2023

The purpose of this study was to examine the experiences of woman after their partner’s infidelity, whether to stay or choose to separate. This study uses a qualitative methode with a phenomenological approach. Data was collected through semi-structured in-dept interviews and informants in this study were selected through purposive techniques based on considerations of suitability with the problem and research abjectives. The informants in this study amounted to two women who were the research subjects with the problem of husband’s infidelity. Based on the result of the study, it can be concluded that in the end the experience of woman who experience infidelity with their partners will shoose to end their housedhold or choosed to separate.
Keywords: Woman, infidelity, endure, separate.
ОРГАНІЗАЦІЙНЕ ВИВЧЕННЯ І ВПРОВАДЖЕННЯ ДОСВІДУ ЗБРОЙ¬НИХ СИЛ УКРАЇНИ У МІЖНАРОДНИХ ОПЕРАЦІЯХ ІЗ ПІДТРИМАННЯ МИРУ ТА БЕЗПЕКИ
Authors: Пащук Юрій Михайлович 
Published: June 2023

Стаття присвячена організаційному (колективному) вивченню та впров­дженню досвіду українських національних контингентів у міжнародних операціях із підтримання миру та безпеки, а також його впливу на розвиток стандартного процесу вивчення та впровдження досвіду у Збройних Силах України. Вище­зазначена діяльність досліджується протягом двох основних періодів еволюції організаційного вивчення та впровдження досвіду в Збройних Силах України: 1) грудень 1991 р. – грудень 2018 р.; 2) січень 2019 р. – лютий 2022 р.
Необхідність вивчення воєнно-історичних аспектів із аналізу та імплементації досвіду Збройних Сил України в операціях із підтримання миру зумовлена, насамперед, важливістю таких досліджень для забезпечення більш ефективного функціонування сучасної Системи вивчення та впровдження досвіду в умовах протистояння російській збройній агресії. Важливість та актуальність цього науково-практичного завдання визначається також відсутністю в українській історіографії спеціальних досліджень.
Розглянуті у статті два вищезгадані періоди відрізняються, насамперед, процесами та процедурами аналізу та імплементації набутих колективних знань, а також мають різну здатність до їх засвоєння і трансформації. Крім того, вони характеризуються неоднаковою роллю та внеском українського військового досвіду участі в міжнародних операціях із підтримання миру в розвиток органі­заційного вивчення та впровдження досвіду в Збройних Силах України. До початку російської збройної агресії у 2014 році організаційне вивчення та впровдження досвіду міжнародних операцій із підтримання миру відігравало провідну роль, і ця діяльність мала значний вплив на розвиток процесів вивчення та впрова­дження досвіду у Збройних Силах України. Після початку Антитерористичної операції у квітні 2014 року з очевидних причин така діяльність не була най­вищим пріоритетом. Але практика та передовий досвід аналізу та імплементації досвіду в операціях із підтримання миру широко використовувався для карди­нальної переорієнтації на організаційне вивчення та впровадження бойового досвіду і стала відправною точкою подальшого розвитку процесів і процедур вивчення та впровдження досвіду у Збройних Силах України.
Зі створенням у 2019 році перспективної Системи вивчення та впровадження досвіду у Збройних Силах України було розроблено та затверджено Доктрину з вивчення та впровадження досвіду та Інструкцію зі збору спостережень, ідентифі­кації, поширення та впровадження уроків і передового досвіду. Українські війська також отримали відповідні процедури аналізу та впровадження досвіду українських національних контингентів у міжнародних операціях із підтримання миру та безпеки.
A novel glycolysis-related gene signature for predicting the prognosis of multiple myeloma
Authors: Zhang Bingxin , Wang Quanqiang , Lin Zhili , Zheng Ziwei , Zhou Shujuan , Zhang Tianyu , Zheng Dong , Chen Zixing , Zheng Sisi , Zhang Yu , Lin Xuanru , Dong Rujiao , Chen Jingjing , Qian Honglan , Hu Xudong , Zhuang Yan , Zhang Qianying , Jin Zhouxiang , Jiang Songfu , Ma Yongyong 
Published: June 2023

Background: Metabolic reprogramming is an important hallmark of cancer. Glycolysis provides the conditions on which multiple myeloma (MM) thrives. Due to MM’s great heterogeneity and incurability, risk assessment and treatment choices are still difficult.Method: We constructed a glycolysis-related prognostic model by Least absolute shrinkage and selection operator (LASSO) Cox regression analysis. It was validated in two independent external cohorts, cell lines, and our clinical specimens. The model was also explored for its biological properties, immune microenvironment, and therapeutic response including immunotherapy. Finally, multiple metrics were combined to construct a nomogram to assist in personalized prediction of survival outcomes.Results: A wide range of variants and heterogeneous expression profiles of glycolysis-related genes were observed in MM. The prognostic model behaved well in differentiating between populations with various prognoses and proved to be an independent prognostic factor. This prognostic signature closely coordinated with multiple malignant features such as high-risk clinical features, immune dysfunction, stem cell-like features, cancer-related pathways, which was associated with the survival outcomes of MM. In terms of treatment, the high-risk group showed resistance to conventional drugs such as bortezomib, doxorubicin and immunotherapy. The joint scores generated by the nomogram showed higher clinical benefit than other clinical indicators. The in vitro experiments with cell lines and clinical subjects further provided convincing evidence for our study.Conclusion: We developed and validated the utility of the MM glycolysis-related prognostic model, which provides a new direction for prognosis assessment, treatment options for MM patients.
Is obesity associated with taste alterations? a systematic review
Authors: Peinado Beatriz Rodrigues Risuenho , Frazão Deborah Ribeiro , Bittencourt Leonardo Oliveira , Souza-Rodrigues Renata Duarte de , Vidigal Maria Tereza Campos , da Silva Douglas Teixeira , Paranhos Luiz Renato , Magno Marcela Baraúna , Fagundes Nathalia Carolina Fernandes , Maia Lucianne Cople , Lima Rafael Rodrigues 
Published: June 2023

BackgroundObesity is a growing chronic public health problem. The causes of obesity are varied, but food consumption decisions play an important role, especially decisions about what foods to eat and how much to consume. Food consumption decisions are driven, in part, by individual taste perceptions, a fact that can influence eating behavior and, therefore, body mass.MethodologyThe searches were conducted in the electronic databases PubMed, Web of Science, Scopus, Lilacs, and the grey literature (Google Scholar and Open Grey). The acronym PECO will be used, covering studies with adult humans (P) who have obesity (E) compared to adult humans without obesity (C), having as an outcome the presence of taste alterations (O). After searching, duplicates were removed. The articles were first evaluated by title and abstract, following the inclusion and exclusion criteria; then, the papers were read in full. After the studies were selected, two reviewers extracted the data and assessed the individual risk of bias and control statements for possible confounders and bias consideration. The narrative GRADE system performed the methodological quality assessment using the New Castle Ottawa qualifier and analysis of certainty of evidence.ResultsA total of 3782 records were identified from the database search, of these 19 were considered eligible. Forty percent of the eligible studies show that there was an association between obesity and different taste alterations for different flavors comparing with normal weights adults. In the methodological quality analysis of the nineteen studies, which assesses the risk of bias in the results, fifteen showed good methodological reliability, three showed fair methodological reliability, and one showed low methodological reliability.ConclusionDespite methodological limitations, the results of the studies suggest the existence of a association between obesity and taste alterations, but further investigations with more sensitive methodologies are necessary to confirm this hypothesis.Systematic review registrationhttps://osf.io/9vg4h/, identifier 9vg4h.
Linking geological and infrastructural requirements for large-scale underground hydrogen storage in Germany
Authors: Alms Katharina , Ahrens Benedikt , Graf Marieke , Nehler Mathias 
Published: June 2023

Hydrogen storage might be key to the success of the hydrogen economy, and hence the energy transition in Germany. One option for cost-effective storage of large quantities of hydrogen is the geological subsurface. However, previous experience with underground hydrogen storage is restricted to salt caverns, which are limited in size and space. In contrast, pore storage facilities in aquifers -and/or depleted hydrocarbon reservoirs- could play a vital role in meeting base load needs due to their wide availability and large storage capacity, but experiences are limited to past operations with hydrogen-bearing town gas. To overcome this barrier, here we investigate hydrogen storage in porous storage systems in a two-step process: 1) First, we investigate positive and cautionary indicators for safe operations of hydrogen storage in pore storage systems. 2) Second, we estimate hydrogen storage capacities of pore storage systems in (current and decommissioned) underground natural gas storage systems and saline aquifers. Our systematic review highlights that optimal storage conditions in terms of energy content and hydrogen quality are found in sandstone reservoirs in absence of carbonate and iron bearing accessory minerals at a depth of approx. 1,100 m and a temperature of at least 40°C. Porosity and permeability of the reservoir formation should be at least 20% and 5 × 10−13 m2 (∼500 mD), respectively. In addition, the pH of the brine should fall below 6 and the salinity should exceed 100 mg/L. Based on these estimates, the total hydrogen storage capacity in underground natural gas storages is estimated to be up to 8 billion cubic meters or (0.72 Mt at STP) corresponding to 29 TWh of energy equivalent of hydrogen. Saline aquifers may offer additional storage capacities of 81.6–691.8 Mt of hydrogen, which amounts to 3.2 to 27.3 PWh of energy equivalent of hydrogen, the majority of which is located in the North German basin. Pore storage systems could therefore become a crucial element of the future German hydrogen infrastructure, especially in regions with large industrial hydrogen (storage) demand and likely hydrogen imports via pipelines and ships.