bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method to evidence hypernuclear halos from a two-target interaction cross section measurement
Authors: Velardita Simone , Alvarez-Pol Hector , Aumann Thomas , Ayyad Yassid , Duer Meytal , Hammer Hans-Werner , Ji Liancheng , Obertelli Alexandre , Sun Yelei 
Published: June 2023

AbstractWe present a two-target measurement method to determine the interaction cross section of hypernuclei with a target nucleus. The method allows to extract from two independent measurements the production cross section of a given hypernucleus as well as its interaction cross section on a specific target. The latter is then further analyzed to deduce the matter radius of the hypernucleus. The sensitivity of the method has been investigated for the specific case of the lightest hyperhalo candidate hypertriton ($$^3_\Lambda $$

Λ
3

H) produced from $$^{12}$$

12

C+$$^{12}$$

12

C collisions at 1.9 GeV/nucleon. Furthermore, its feasibility is demonstrated by detailed simulations for realistic experimental conditions at GSI/FAIR, using a dedicated HYDRA (HYpernuclei Decay at R$$^3$$

3

B Apparatus) time-projection chamber prototype. A precision of 15% or better in the interaction cross section can be achieved, allowing an extraction of the unknown $$^3_\Lambda $$

Λ
3

H matter radius and assessing its halo or non-halo character.
Emergency General Surgery Transfers to Definitive Care: An Assessment of Patient and Systemic Factors in Appendicitis Referrals
Authors: Kanney Jill , Distler Katerina , Santini Jon , Rostedt Leslie , Collopy Kevin , Powers William F. 
Published: June 2023

Patients presenting to the emergency department (ED) with an Emergency General Surgery (EGS) problem often require transfer to a tertiary facility. Issues impacting EGS mirror the same issues trauma surgery faced prior to the implementation of current trauma guidelines. This study analyzed the cost, time, and transport resource utilization of EGS patients with acute appendicitis when transferred from network hospitals to a level II trauma center. This was a retrospective study. Patients were transferred by a critical or specialty care transport team 62% of the time, although no skills performed required a critical or specialty care provider. The median time from decision to transfer to incision was 254 minutes, with an average transport time of 27 minutes. This study suggests that there is an opportunity to improve access to the operating room and to decrease resource utilization of specialty care and critical care transport for patients.
Global, regional, and national burden and quality of care index (QCI) of bipolar disorder: A systematic analysis of the Global Burden of Disease Study 1990 to 2019
Authors: Aghababaie-Babaki Paria , Malekpour Mohammad-Reza , Mohammadi Esmaeil , Saeedi Moghaddam Sahar , Rashidi Mohammad-Mahdi , Ghanbari Ali , Heidari-Foroozan Mahsa , Esfahani Zahra , Mohammadi Fateh Sahar , Hajebi Amirali , Haghshenas Rosa , Foroutan Mehr Elmira , Rezaei Negar , Larijani Bagher , Farzadfar Farshad 
Published: June 2023

Background: Bipolar disorders (BD) are significant debilitating mental problems. Here, we introduced a novel index as a representative of the quality of care delivered to BD patients worldwide. Methods: The Global Burden of Disease (GBD) 2019 study was the primary data source on BD, including prevalence, incidence, and years lived with disability (YLDs). Secondary indices were created and transformed into a single component that accounted for most of the variation, using the Principal Component Analysis (PCA) method. This component, reported on a scale of 0 to 100, was presented as the quality of care index (QCI). The QCI was estimated in different age groups and areas within a 30-year time frame. Gender disparity ratio (GDR), as the female-to-male ratio of the QCI, was reported. Results: The Global QCI slightly increased from 50.4 in 1990 to 53.1 in 2019. The GDR value was 0.95 in 2019. The high-middle SDI quintile had the highest QCI estimate of 63.0, and the lowest QCI value of 36.9 was regarding the low SDI quintile. Western-Pacific Region and South-East Asia had the highest and lowest QCI among WHO regions, with estimates of 70.7 and 31.2, respectively. The age group of 20 to 24 years old patients reported the lowest QCI estimate of 30.2, and the highest QCI of 59.8 was regarding 40 to 44 years old patients. Conclusion: The QCI in BD had only a subtle increase from 1990 to 2019 and is in need of further improvement. Inequalities between different regions and age groups are considerable and require proper attention.
COVID-19 risk mitigation in reopening mass cultural events: population-based observational study for the UK Events Research Programme in Liverpool City Region
Authors: Burnside Girvan , Cheyne Christopher P , Leeming Gary , Humann Michael , Darby Alistair , Green Mark A , Crozier Alexander , Maskell Simon , O’Halloran Kay , Musi Elena , Carmi Elinor , Khan Naila , Fisher Debra , Corcoran Rhiannon , Dunning Jake , Edmunds W John , Tharmaratnam Kukatharmini , Hughes David M , Malki-Epshtein Liora , Cook Malcolm , Roberts Ben M , Gallagher Eileen , Howell Kate , Chand Meera , Kemp Robin , Boulter Matthew , Fowler Tom , Semple Malcolm G , Coffey Emer , Ashton Matt ,   The COVID-19 Genomics UK (COG-UK) Consortium, García-Fiñana Marta , Buchan Iain E 
Published: June 2023

Objectives To understand severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission risks, perceived risks and the feasibility of risk mitigations from experimental mass cultural events before coronavirus disease 2019 (COVID-19) restrictions were lifted. Design Prospective, population-wide observational study. Setting Four events (two nightclubs, an outdoor music festival and a business conference) open to Liverpool City Region UK residents, requiring a negative lateral flow test (LFT) within the 36 h before the event, but not requiring social distancing or face-coverings. Participants A total of 12,256 individuals attending one or more events between 28 April and 2 May 2021. Main outcome measures SARS-CoV-2 infections detected using audience self-swabbed (5–7 days post-event) polymerase chain reaction (PCR) tests, with viral genomic analysis of cases, plus linked National Health Service COVID-19 testing data. Audience experiences were gathered via questionnaires, focus groups and social media. Indoor CO2 concentrations were monitored. Results A total of 12 PCR-positive cases (likely 4 index, 8 primary or secondary), 10 from the nightclubs. Two further cases had positive LFTs but no PCR. A total of 11,896 (97.1%) participants with scanned tickets were matched to a negative pre-event LFT: 4972 (40.6%) returned a PCR within a week. CO2 concentrations showed areas for improving ventilation at the nightclubs. Population infection rates were low, yet with a concurrent outbreak of >50 linked cases around a local swimming pool without equivalent risk mitigations. Audience anxiety was low and enjoyment high. Conclusions We observed minor SARS-CoV-2 transmission and low perceived risks around events when prevalence was low and risk mitigations prominent. Partnership between audiences, event organisers and public health services, supported by information systems with real-time linked data, can improve health security for mass cultural events.
Walking ability of individuals fitted with transfemoral bone-anchored prostheses: A comparative study of gait parameters
Authors: Ranaldi Simone , Naaim Alexandre , Marchis Cristiano De , Robert Thomas , Dumas Raphael , Conforto Silvia , Frossard Laurent 
Published: June 2023

Objective This study presents the walking abilities of participants fitted with transfemoral bone-anchored prostheses using a total of 14 gait parameters. Design Two-centre retrospective cross-sectional comparative study. Setting Research facilities equipped with tridimensional motion capture systems. Participants Two control arms included eight able-bodied participants arm (54 ± 9 years, 1.75 ± 0.07 m, 76 ± 7 kg) and nine participants fitted with transfemoral socket-suspended prostheses arm (59 ± 9 years, 1.73 ± 0.07 m, 80 ± 16 kg). The intervention arm included nine participants fitted with transfemoral bone-anchored prostheses arm (51 ± 13 years, 1.78 ± 0.09 m, 87.3 ± 16.1 kg). Intervention Fitting of transfemoral bone-anchored prostheses. Main measures Comparisons were performed for two spatio-temporal, three spatial and nine temporal gait parameters. Results The cadence and speed of walking were 107 ± 6 steps/min and 1.23 ± 0.19 m/s for the able-bodied participants arm, 88 ± 7 steps/min and 0.87 ± 0.17 m/s for the socket-suspended prosthesis arm, and 96 ± 6 steps/min and 1.03 ± 0.17 m/s for bone-anchored prosthesis arm, respectively. Able-bodied participants and bone-anchored prosthesis arms were comparable in age, height, and body mass index as well as cadence and speed of walking, but the able-bodied participant arm showed a swing phase 31% shorter. Bone-anchored and socket-suspended prostheses arms were comparable for age, height, mass, and body mass index as well as cadence and speed of walking, but the bone-anchored prosthesis arm showed a step width and duration of double support in seconds 65% and 41% shorter, respectively. Conclusions Bone-anchored and socket-suspended prostheses restored equally well the gait parameters at a self-selected speed. This benchmark data provides new insights into the walking ability of individuals using transfemoral bionics bone-anchored prostheses.
The New Zealand drug harms ranking study: A multi-criteria decision analysis
Authors: Crossin Rose , Cleland Lana , Wilkins Chris , Rychert Marta , Adamson Simon , Potiki Tuari , Pomerleau Adam C , MacDonald Blair , Faletanoai Dwaine , Hutton Fiona , Noller Geoff , Lambie Ian , Sheridan Jane L , George Jason , Mercier Kali , Maynard Kristen , Leonard Louise , Walsh Patricia , Ponton Rhys , Bagshaw Sue , Muthukumaraswamy Suresh , McIntosh Tracey , Poot Edward , Gordon Paul , Sharry Patrick , Nutt David , Boden Joseph 
Published: June 2023

Aims: The harms arising from psychoactive drug use are complex, and harm reduction strategies should be informed by a detailed understanding of the extent and nature of that harm. Drug harm is also context specific, and so any comprehensive assessment of drug harm should be relevant to the characteristics of the population in question. This study aimed to evaluate and rank drug harms within Aotearoa New Zealand using a multi-criteria decision analysis (MCDA) framework, and to separately consider harm within the total population, and among youth. Methods: Two facilitated workshops involved the separate ranking of harm for the total population, and then for youth aged 12–17, by two expert panels. In the total population workshop, 23 drugs were scored against 17 harm criteria, and those criteria were then evaluated using a swing weighting process. Scoring and weighting were subsequently updated during the youth-specific workshop. All results were recorded and analysed using specialised MCDA software. Results: When considering overall harm, the MCDA modelling results indicated that alcohol, methamphetamine and synthetic cannabinoids were the most harmful to both the overall population and the youth, followed by tobacco in the total population. Alcohol remained the most harmful drug for the total population when separately considering harm to those who use it, and harm to others. Conclusions: The results provide detailed and context-specific insight into the harm associated with psychoactive drugs use within Aotearoa New Zealand. The findings also demonstrate the value of separately considering harm for different countries, and for different population subgroups.
Influence of Fatigue on Cognitive-Motor Function During Unanticipated Landings
Authors: Bertozzi Filippo , Fischer Patrick D. , Aflatounian Fatemeh , Hutchison Keith A. , Sforza Chiarella , Monfort Scott M. 
Published: June 2023

Background: Physical fatigue and cognitive performance have been suggested as risk factors for an anterior cruciate ligament (ACL) injury, and fatigue has also been demonstrated to reduce cognitive processing. The combined effects of fatigue and lower cognitive function during cognitive-challenging movements may increase knee mechanics associated with the ACL injury risk. Hypotheses: We hypothesized that (1) knee mechanics would be detrimentally affected by fatigue and associated with baseline cognitive function and (2) fatigue-induced deleterious changes in cognitive performance and knee mechanics would be correlated. Study Design: Descriptive laboratory study. Methods: A total of 22 athletes completed baseline cognitive testing. After performing maximal vertical jumps, they performed a jump-land-jump task based on unanticipated visual cues. Then, they completed a fatigue protocol including countermovement jumps, among other tasks, until the jump height decreased below 90% of their assessed maximum. Immediately after reaching the first fatigue point, they performed another set of jump-landing tasks, followed by repeating the fatigue protocol until the jump height decreased below 85% of their assessed maximum. After reaching the second fatigue point, they performed a final set of jump-landing tasks and repeated the initial cognitive assessment battery. Results: Mixed-effects models revealed that knee flexion decreased through the fatigue protocol (baseline: 61.8°; midpoint: 61.1°; final: 60.1°; P = .003). Stepwise regression showed that fatigue-worsened attentional control corresponded to smaller knee abduction angles ( R2adjusted = 51.68%; βstandardized = 1.16; P = .001), and worse reaction time after fatigue correlated with increased knee abduction angles (βstandardized = 0.85; P = .006) after accounting for the role of attentional control. Conclusion: Fatigue induced incremental modifications in sagittal-plane knee mechanics during an unanticipated sports movement. In addition, fatigue induced changes in cognitive function related to ACL injury–relevant knee mechanics. Clinical Relevance: The novel findings regarding fatigue-dependent changes in injury-relevant biomechanics during cognitively challenging movements represent an extension of recent developments in understanding the role of cognition in the ACL injury risk.
Synthesis and Characterization of Citrus limonum Copper Nanoparticles and its in vitro Evaluation of Cytotoxicity against JURKAT Cells
Authors: Makki Huda Jameel , Chandrasekharaiah KS 
Published: June 2023

Background Biosynthesized copper nanoparticles (CuNPs) are eco-friendly, cost-effective, and biocompatible agents reported for extensive biomedical and bioengineering applications. Different chemical synthesis approaches have been established recently, with challenges of higher toxicity and high cost involved in the synthesis process. Green synthesized nanoparticles emerged and was extensively reported to address the challenges faced by traditional chemical synthesis processes. However, the high toxicity remains a significant challenge for translating the green synthesized nanoparticles into clinically valuable products. Purpose To synthesize, characterize, and evaluate the citrus extract-based CuNps cytotoxicity against JURKAT cell lines. Materials and Methods An aqueous extract of the citrus fruit was used as a reducing agent, and the CuNps were synthesized. Fourier Transform Infra-Red (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), Ultraviolet-visible (UV-vis) spectrophotometry, and X-ray diffraction (XRD) were used to confirm the synthesis of CuNp and its structure. Furthermore, the effect of CuNPs on cell viability and toxicity was evaluated by mitochondrial toxicity tests (MTT) and LDH assays against the JURKAT cell lines. Results and Conclusion The synthesized nanoparticle’s size ranged from 40 to 70 nm, as confirmed through nanoparticle tracking analysis (NTA) and SEM. The synthesized nanoparticles were confirmed to be anti-proliferative with a high percent of cytotoxicity as found from MTT and LDH leakage assays. The size and shape of the synthesized CuNPs as studied by SEM were found to be 30–70 nm and more or less spherical. MTT reported 64.87% inhibition at 320 µg/mL with an IC50 value of 80.78 µg/mL ( p < 0.05). Cytotoxicity as measured by the LDH assay was found to be 53.12 ± 0.89% at 320 µg/mL with an IC50 of 23.12 ± 0.39 when compared to the positive control (11.21 ± 0.15 µg/mL). Green-synthesized CuNPs exhibited potential anti-cancerous activity in JURKAT cell lines, as evidenced by the LDH and MTT assays.
Pilot study of a group clinical supervision model for medical students
Authors: Moran Abby , Shanahan Amelia , Tomlin Alison , Ivers Rowena , Thomas Susan J 
Published: June 2023

Objective To trial a clinical supervision model with medical students, co-designed by students and clinicians, and evaluate its feasibility, acceptability, and perceived benefits. Method Two clinical supervision groups, one online and one face-to-face, were conducted for six one-hour sessions, over 12 weeks. Clinical supervision was evaluated through mixed methods including attendance levels, focus groups, and quantitative surveys. Results Thirteen students participated, including one rural and one regional group, each with a clinical supervisor. Attendance was 100%. Students viewed clinical supervision as a safe time for reflection on clinical experiences, validation from senior clinicians and peers, and connection to the medical community. Themes that emerged included strategies to prevent moral injury, self-care, and the need for a trusted clinical supervisor. Conclusion The clinical supervision model received positive medical student evaluations and 100% attendance. This shows promise as an avenue to professionally support medical students as they navigate complex clinical training.
Implementation of Partnered Pharmacist Medication Charting in haematology and oncology inpatients
Authors: Tong Erica Y , Edwards Gail E , Hua Phuong Uyen , Mitra Biswadev , Dyk Eleanor Van , Yip Gary , Coutsouvelis John , Siderov Jim , Tran Yen , Dooley Michael J 
Published: June 2023

Aim Partnered Pharmacist Medication Charting (PPMC) in patients admitted under general medical units has been shown to reduce medication errors. The aim of this study is to evaluate the impact of the PPMC model on medication errors in patients admitted under cancer units in Victorian hospitals. Methods A prospective cohort study comparing cohorts before and after the introduction of PPMC was conducted. This included a 2-month pre-intervention phase and 3-month intervention phase. PPMC was implemented during the intervention phase as new model of care that enabled credentialed pharmacists to chart all admission medications, including pre-admission or new medications and cancer therapies, in collaboration with the admitting medical officer. The proportion of medication charts with at least one error was the primary outcome measure. Results Seven health services across Victoria were included in the study. The majority of health services were using paper-based prescribing systems for oncology. Of the 547 patients who received standard medical medication charting, 331 (60.5%) had at least one medication error identified compared to 18 out of 416 patients (4.3%) using the PPMC model (p < 0.001). The median (interquartile range) inpatient length of stay was 5 (2.9–10.6) days in pre-intervention and 4.9 (2.9–11) days in intervention (p  =  0.88). In the intervention arm, 42 patients had cancer therapy charted by a pharmacist with no errors. Conclusions PPMC was successfully scaled into cancer units as a collaborative medication safety strategy. The model was associated with significantly lower rates of medication errors, including cancer therapies. PPMC should be adopted more widely in cancer units in Australia.
Retrospective evaluation of surgical treatment of linear and discrete gastrointestinal foreign bodies in cats: 2009–2021
Authors: Gollnick Hailey R , Schmiedt Chad W , Wallace Mandy L , Sutherland Brian J , Grimes Janet A 
Published: June 2023

Objectives Gastrointestinal foreign bodies (FBs) are an important cause of emergency surgical intervention in cats, but little information exists in the literature evaluating the risks and outcomes in this species. The study purpose was to describe cases of feline FBs and compare perioperative factors and outcomes between linear foreign body (LFB) and discrete foreign body (DFB) surgery in cats. Methods The medical records from the University of Georgia Veterinary Teaching Hospital were searched for cats that had undergone surgery for FB removal between August 2009 and August 2021. Perioperative data were collected and described. Data were compared between cats with an LFB and cats with a DFB. A binomial probability series was used to estimate the likelihood of postoperative septic peritonitis or mortality in an additional cat in the series. Results A total of 56 cats were included in this study; 38 cats had a DFB and 18 had an LFB. No cats developed postoperative septic peritonitis, and all cats survived. The likelihood of postoperative septic peritonitis or mortality in an additional cat was estimated to be <5.2%. Cats with an LFB were found to have a significantly higher body condition score ( P = 0.047), albumin ( P = 0.025), American Society of Anesthesiologists status ( P = 0.027), surgery length ( P <0.001) and total cost of visit ( P = 0.006) when compared with cats with a DFB. Cats with LFBs were more likely to develop a surgical site infection (SSI; P = 0.007) and be administered postoperative antibiotics ( P = 0.017). Conclusions and relevance Cats undergoing surgery for gastrointestinal FBs had a low incidence of postoperative complications. Cats with LFBs had longer surgeries and were more likely to develop postoperative SSIs.
Neurogenic dry eye associated with intravitreal injection of anti-VEGF agents
Authors: Lin Shu-Hua , Fang Yu-Hui , Jia Fa-li , Li Ying-Jun 
Published: June 2023

Purpose To report a case of neurogenic dry eye (NDE) that developed after intravitreal ranibizumab injection (IVR). Case report A 71-year-old woman had a history of cataract phacoemulsification and intraocular lens (IOL) implantation, Nd:YAG laser posterior capsulotomy and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). Aneurysmal dilatation of the inferior temporal retina was found in the left fundus, which was diagnosed as retinal aneurysm, and intravitreal ranibizumab injection was administered. Dry eye was found in the left eye after the first injection. After the second injection, the patient developed severe dry eye with left eye dryness, photophobia, irritation, and blurred vision. The tear film breakup time (TBUT) value was 3 s, the Schirmer test value was 2 mm/5 min, corneal fluorescein staining (CFS) showed diffuse patellar staining of the corneal epithelium with a staining area of >50% and irregular staining at the edge of the corneal flap, and the corneal touch threshold value in the filament length was 1.5 cm in the left eye. Conclusions Patients with a history of intraocular lens implantation, Nd:YAG laser posterior capsulotomy, and femtosecond laser-assisted laser in situ keratomileusis surgery may have increased drug permeability due to an increased concentration of anti-VEGF drugs in the aqueous layer and thinning of the stromal layer of the cornea. The corneal subepithelial nerve repair mechanism was destroyed, causing neurogenic dry eye.