bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Adaptive Job Shop Scheduling Mechanism for Disturbances by Running Reinforcement Learning in Digital Twin Environment
Authors: Fang Weiguang , Zhang Hao , Qian Weiwei , Guo Yu , Li Shaoxun , Liu Zeqing , Liu Chenning , Hong Dongpao 
Published: April 2023

Abstract
Practical manufacturing system operates in highly dynamic and uncertain environments, where stochastic disturbances disrupt the execution of the production schedule as originally developed. Previous dynamic scheduling mainly focuses on the constructing predictive models for machine unavailability, with little studies on the adaptive and self-learning capacities for changing scheduling environments. Therefore, a digital twin (DT) driven scheduling with a dynamic feedback mechanism is proposed, in which a reinforcement learning (RL) based adaptive scheduling is developed in DT to make corrective decisions for the disturbances during production runs. In the proposed architecture, the happening disturbance is first detected in the virtual layer by the status continuously updating in accordance with the physical workshop. Furthermore, the reschedule triggering condition is determined in real-time through the calculation of the progress deviations resulting from disturbances. For the scheduling approach, the distributed RL (DRL) based adaptive scheduling method is built to perceive the dynamic production status from virtual environment and implement corrective strategies to hedge against the occurred disturbances. Finally, the proposed method is verified by a practical job shop case and the corresponding DT system is developed to show the effectiveness and advantages after a practical implementation.
A 3D Structure Mapping-Based Efficient Topology Optimization Framework
Authors: Li Kangjie , Ye Wenjing , Gao Yicong 
Published: April 2023

Abstract
It is well known that the computational cost of classic topology optimization (TO) methods increases rapidly with the size of the design problem because of the high-dimensional numerical simulation required at each iteration. Recently, the technical route of replacing the TO process with artificial neural network (ANN) models has gained popularity. These ANN models, once trained, can rapidly produce an optimized design solution for a given design specification. However, the complex mapping relationship between design specifications and corresponding optimized structures presents challenges in the construction of neural networks with good generalizability. In this paper, we propose a new design framework that uses deep learning techniques to accelerate the TO process. Specifically, we present an efficient topology optimization (ETO) framework in which structure update at each iteration is conducted on a coarse scale and a structure mapping neural network (SMapNN) is constructed to map the updated coarse structure to its corresponding fine structure. As such, fine-scale numerical simulations are replaced by coarse-scale simulations, thereby greatly reducing the computational cost. In addition, fragmentation and padding strategies are used to improve the trainability and adaptability of SMapNN, leading to a better generalizability. The efficiency and accuracy of the proposed ETO framework are verified using both benchmark and complex design tasks. It has been shown that with the SMapNN, TO designs of millions of elements can be completed within a few minutes on a personal computer.
kalypso Autonomous Underwater Vehicle: A 3D-Printed Underwater Vehicle for Inspection at Fisheries
Authors: Vasileiou Marios , Manos Nikolaos , Vasilopoulos Nikos , Douma Anastasia , Kavallieratou Ergina 
Published: April 2023

Abstract
In fish farms, a major issue is the net cage wear, resulting in fish escapes and negative impact on fish quality, due to holes and biofouling of the nets. To minimize fish losses, fisheries utilize divers to inspect net cages on a weekly basis. Aquaculture companies are looking for ways to maximize profit, and reducing maintenance costs is one of them. Kefalonia Fisheries spend 250,000 euros yearly on diver expenses for net cages maintenance. This work is about the design, fabrication, and control of an inexpensive autonomous underwater vehicle (AUV) intended for inspection in net cages at Kefalonia Fisheries S.A. in Greece. Its main body is 3D printed, and its eight-thruster configuration grants it six degrees-of-freedom. The main objective of the vehicle is to limit maintenance costs by increasing inspection frequency. The design, fabrication, electronic components, and software architecture of the AUV are presented. In addition, the forces affecting kalypso, mobility realization, navigation, and modeling are quoted along with a flow simulation and the experimental results. The proposed design is adaptable and durable while remaining cost-effective, and it can be used for both manual and automatic operations.
Effects of Changes in Body Fat Mass as a Result of Regular Exercise on Hemoglobin A1c in Patients With Type 2 Diabetes Mellitus: A Meta-Analysis
Authors: Igarashi Yutaka , Akazawa Nobuhiko , Maeda Seiji 
Published: April 2023

An increase in visceral fat is associated with an increase in insulin resistance, so reducing body fat mass through exercise may help alleviate type 2 diabetes mellitus (T2DM). The current meta-analysis evaluated the effect of changes in body fat via an intervention of regular exercise on hemoglobin A1c (HbA1c) in patients with T2DM. The inclusion criteria were randomized controlled trials involving adults with T2DM, intervention involving exercise alone, an overall duration of intervention ≥12 weeks, and reporting HbA1c and body fat mass. The mean differences (MDs) were defined as the MD between the exercise group and the control group, and the MDs in HbA1c (in percentage) and body fat mass (in kilograms) were calculated. All MDs in HbA1c were pooled as overall effects. A meta-regression analysis was performed to evaluate the relationship between the MD in the body fat mass (in kilograms) and the MD in HbA1c. Twenty studies (1,134 subjects) were analyzed. The pooled MD in HbA1c (in percentage) decreased significantly (−0.4; 95% confidence interval [−0.5, −0.3]) but contained significant heterogeneity (Q = 52.7, p < .01; I2 = 41.6%). A meta-regression analysis showed that a decrease in the MD in body fat mass was significantly associated with a decrease in the MD in HbA1c (R2 = 80.0%) and heterogeneity decreased (Q = 27.3, p = .61; I2 = 11.9%), and a reduction in body fat mass of 1 kg was estimated to decrease the HbA1c (%) by approximately 0.2. The current study suggested that a decrease in HbA1c due to regular exercise depends on a reduction in body fat mass in patients with T2DM.
Discovery of a giant 3.3–3.1 Ga terrane in the Rae craton, Canada: Implications for the timing and extent of ancient continental growth
Authors: Neil Benjamin J.C. , Tersmette Daniel B. , Chacko Thomas , Heaman Larry M. , Kjarsgaard Bruce A. , Martel Edith , Creaser Robert A. , Pearson D. Graham , Stern Richard A. , Dufrane S. Andrew , Luo Yan 
Published: April 2023

Abstract
We report the discovery of one of the largest ancient (&gt;3.0 Ga) crustal terranes on Earth. Granitoids with crystallization ages &gt;3.0 Ga and/or Sm-Nd depleted mantle model ages ≥3.2 Ga define a ~1000 × 100 km belt on the western margin of the Rae craton, Canada, referred to herein as the Perry River terrane (PRT). Zircon U-Pb-Hf-O isotope and whole-rock geochemical data from granitoids show that the PRT is a predominantly juvenile 3.3–3.2 Ga terrane that was partially reworked by more evolved ca. 3.1 Ga magmatism. These findings call for a reassessment of the timing and extent of ancient continental growth on Earth. A global compilation of zircon Hf isotope data from 3.6 to 3.0 Ga igneous rocks reveals clusters of relatively juvenile (initial εHf −2 to +3) rocks at ca. 3.31 and ca. 3.23 Ga, which include samples from the PRT and 13 other terranes worldwide. Other global zircon data sets also document age peaks between 3.3 and 3.2 Ga, and a cluster of broadly chondritic initial εHf values around 3.2 Ga. The 3.3–3.2 Ga period may therefore have been a time of enhanced net continental growth on Earth, and the PRT is one of the largest terranes preserved from that time. Furthermore, zircon Hf isotope data from 3.3–3.1 Ga PRT granitoids and 3.5–3.0 Ga igneous rocks worldwide yield little evidence for parent magmas that interacted with or derived from pre–3.6 Ga continental material. Contrary to some continental-growth models, this latter observation suggests that the volume of continental crust established by 3.6 Ga was relatively small.
Impact of the COVID-19 pandemic on working conditions and mental well-being of mental health professionals in the Netherlands: a cross-sectional study
Authors: van Doesum Tessa J , Shields-Zeeman Laura S , Leone Stephanie S , van Meijel Berno , Jabbarian Lea J , van Bon-Martens Marja 
Published: April 2023

ObjectivesTo examine the extent of the impact of the COVID-19 pandemic on the mental health and well-being of mental health professionals (MHPs) in the Netherlands and understand their needs during the COVID-19 pandemic.Design and settingA cross-sectional, mixed-methods study was conducted with MHPs from the Netherlands from June 2020 to October 2020, consisting of an online survey and three online focus group discussions.ParticipantsParticipants were MHPs from various occupational groups (psychologists, social workers, mental health nurses, developmental education workers, etc).Primary and secondary outcome measuresThe online survey included questions about work-related changes due to COVID-19 perceived resilience to stress, changes in lifestyle behaviours and mental health symptoms. The focus group discussions focused mostly on work experiences during the first wave of the COVID-19 pandemic.ResultsMHP’s reported an increase in experience workload during the pandemic (mean score 8.04 based on a scale of 1-10) compared to before the pandemic (mean score of 7). During the first wave of the pandemic, 50% of respondents reported increased stress, 32% increased sleeping problems and 24% increased mental health problems. Adverse occupational (eg, increased workload OR 1.72, 95% CI 1.28–2.32), psychological (eg, life satisfaction OR 0.63, 95% CI 0.52–0.75), lifestyle (eg, increased sleep problems OR 2.80, 95% CI 2.07–3.80) and physical factors (decline in physical health OR 3.56, 95% CI 2.61–4.85) were associated with a decline in mental health. Participants expressed significant concern in the focus group discussions about the duration of the pandemic, the high workload, less work-life balance and lack of contact with colleagues. Suggestions to improve working conditions included ensuring clear communication about guidelines and facilitating worker contact and support via peer-to-peer coaching where experiences can be shared.ConclusionsThe current study indicates that MHP experienced a decline in mental health status during the first wave of the COVID-19 pandemic, which should be taken into consideration by employers, policymakers and researchers.
Effectiveness and safety of implementing an enhanced patient comfort programme for elective neurosurgical patients: a randomised controlled trial protocol
Authors: Liu Bolin , Liu Shujuan , Wang Binrong , Liu Wenjuan , Chen Lei , Zheng Tao , Lu Dan , Ma Tao , He Shiming 
Published: April 2023

IntroductionPatient comfort is an important quality indicator of healthcare. According to Kolcaba’s comfort theory, enhanced comfort is achieved by meeting the needs in four contexts: physical, psychospiritual, sociocultural and environmental. An enhanced patient comfort (EPC) programme based on this theory has been designed for elective neurosurgical patients. This study aims to assess its feasibility, effectiveness and safety.Methods and analysisThe EPC programme patients will be evaluated in a single institutional randomised controlled trial. A total of 110 patients admitted for elective neurosurgery (including craniotomy, endoscopic trans-sphenoidal surgery and spine surgery) will be randomised in a 1:1 ratio to two groups. Patients in the EPC group are managed under the newly developed EPC programme, which aims to enhance patient experience and includes care coordination since admission (such as appointment of a care support coordinator, personalised setting, and cultural and spiritual support), preoperative management (such as lifestyle intervention, potential psychological and sleep intervention, and prerehabilitation), intraoperative and anaesthetic management (such as nurse coaching, music playing, and pre-emptive warming), postoperative management (such as early extubation, early diet advancement, mood and sleep management, and early ambulation) and optimised discharge planning; while those in the control group receive conventional perioperative care. The primary outcome is patient satisfaction and comfort measured by the Chinese Surgical Inpatient Satisfaction and Comfort Questionnaire. The secondary outcomes include postoperative morbidity and mortality, postoperative pain score, postoperative nausea and vomiting, functional recovery status (Karnofsky performance status and Quality of Recovery-15 score), mental status (anxiety and depression), nutritional status, health-related quality of life, hospital length of stay, reoperation and readmission rates, overall cost and patient experience.Ethics and disseminationEthical approval to conduct the study has been obtained from Institutional Review Board of Xi’an International Medical Center (No. 202028). The results will be presented at scientific meetings and published in peer-reviewed journals.Trial registration numberChinese clinical trial registry ChiCTR2000039983.
Feasibility study to evaluate capabilities for conducting psychiatric clinical research within the Rwandan mental healthcare system
Authors: Alphs Larry , Turkoz Ibrahim , Smith-Swintosky Virginia , Keenan Alexander , Abraham Emily , Schotte Alain , Hooker Eileen , Damascene Iyamuremye Jean , Kayiteshonga Yvonne , Bizoza Rutakayile , Mancevski Branislav 
Published: April 2023

ObjectiveTo evaluate the feasibility of conducting a large clinical trial within the Rwandan mental healthcare system that would establish the safety, efficacy and benefit of paliperidone palmitate once-monthly (PP1M) and once-every-3-months (PP3M) long-acting injectable formulations in adults with schizophrenia.Study designAn open-label, prospective feasibility study.Setting/Participants33 adult patients with schizophrenia were enrolled at 3 sites across Rwanda.InterventionsThe study design included 3 phases of treatment: an oral run-in to establish tolerability to risperidone (1 week), lead-in treatment with flexibly dosed PP1M to identify a stable dose (17 weeks) and maintenance treatment with PP3M (24 weeks).Primary and secondary outcome measuresFeasibility endpoints included compliance with governmental and institutional requirements, acceptable supply chain delivery and proper onsite administration of risperidone/PP1M/PP3M, adequate site infrastructure, adequate training of clinical staff and successful completion of study procedures and scales. A variety of study scales were administered to assess outcomes relevant to patients, caregivers, clinicians and payers in Rwanda and other resource-limited settings.ResultsThis study was terminated early by the sponsor because certain aspects of study conduct needed to be addressed to maintain Good Clinical Practice requirements and meet regulatory standards. Results identified areas for improvement in study execution, including study governance, site infrastructure, study preparation and conduct of procedures, study budget and study assessments. Despite the identification of areas in need of adjustment, none of these limitations were considered insurmountable.ConclusionsThis work was designed to strengthen global research in schizophrenia by building the capacity of researchers to prepare and conduct pharmaceutical trials in resource-limited settings. Although the study was ended early, modifications motivated by the results will facilitate the successful design and completion of more comprehensive studies, including an ongoing, follow-up interventional trial of PP1M/PP3M in a larger population of patients in Rwanda.Trial registration numberNCT03713658
Can co-created knowledge mobilisation interventions alter and enhance mindlines to improve childhood eczema care? A UK-based Social Impact Framework evaluation
Authors: Cowdell Fiona , Lax Stephanie , Van Onselen Julie , Pendleton Rose 
Published: April 2023

ObjectiveTo evaluate the impact of using knowledge mobilisation interventions to alter and enhance mindlines and improve childhood eczema care.DesignThe eczema mindlines study involved three stages: (1) mapping and confirming eczema mindlines, (2) intervention development and delivery and (3) analysis of intervention impact. The focus of this paper is on stage 3. Data analysis was guided by the Social Impact Framework to address the questions: (1) what is the impact of this study on individuals and groups? (2) what changes in behaviour and practice have occurred due to their involvement? (3) what mechanisms have enabled these impacts or changes to occur? and (4) what are the recommendations and questions arising from this research?SettingsA deprived inner-city neighbourhood in central England and national/international settings.ParticipantsPatients, practitioners and wider community members exposed to the interventions locally, nationally and internationally.ResultsData revealed tangible multi-level, relational and intellectual impacts. Mechanisms supporting impact included: simplicity and consistency of messages adapted to audience, flexibility, opportunism and perseverance, personal interconnectivity and acknowledgement of emotion. Co-created knowledge mobilisation strategies to alter and enhance mindlines mediated through knowledge brokering were effective in producing tangible changes in eczema care practice and self-management and in ‘mainstreaming’ childhood eczema in positive way across communities. These changes cannot be directly attributed to the knowledge mobilisation interventions, however, the evidence points to the significant contribution made.ConclusionCo-created knowledge mobilisation interventions offer a valuable method of altering and enhancing eczema mindlines across lay-practitioner-wider society boundaries. The Social Impact Framework provides comprehensive method of understanding and documenting the complex web of impact occurring as a result of knowledge mobilisation. This approach is transferable to managing other long-term conditions.
Are cross-sectional safety climate survey results in operating room staff associated with the surgical site infection rates in Swiss hospitals?
Authors: Pfeiffer Yvonne , Atkinson Andrew , Maag Judith , Lane Michael A , Schwappach David , Marschall Jonas 
Published: April 2023

ObjectivesThe aim of this study was to investigate the association between surgical site infections (SSIs), a major source of patient harm, and safety and teamwork climate. Prior research has been unclear regarding this relationship.DesignBased on the Swiss national SSI surveillance and a survey study assessing (a) safety climate and (b) teamwork climate, associations were analysed for three kinds of surgical procedures.Setting and participantsSSI surveillance data from 20 434 surgeries for hip and knee arthroplasty from 41 hospitals, 8321 for colorectal procedures from 28 hospitals and 4346 caesarean sections from 11 hospitals and survey responses from Swiss operating room personnel (N=2769) in 54 acute care hospitals.Primary and secondary outcomesThe primary endpoint of the study was the 30-day (all types) or 1-year (knee/hip with implants) National Healthcare Safety Network-adjusted SSI rate. Its association with climate level and strength was investigated in regression analyses, accounting for respondents’ professional background, managerial role and hospital size as confounding factors.ResultsPlotting climate levels against infection rates revealed a general trend with SSI rate decreasing as the safety climate increased, but none of the associations were significant (5% level). Linear models for hip and knee arthroplasties showed a negative association between SSI rate and climate perception (p=0.02). For climate strength, there were no consistent patterns, indicating that alignment of perceptions was not associated with lower infection rates. Being in a managerial role and being a physician (vs a nurse) had a positive effect on climate levels regarding SSI in hip and knee arthroplasties, whereas larger hospital size had a negative effect.ConclusionsThis study suggests a possible negative correlation between climate level and SSI rate, while for climate strength, no associations were found. Future research should study safety climate more specifically related to infection prevention measures to establish clearer links.
Cohort profile: a longitudinal regional cohort study to assess COVID-19 seroprevalence in blood donors – baseline characteristics of the SeMaCo study participants
Authors: Pohl Robert , Stallmann Christoph , Marquardt Pauline , Kaasch Achim J. , Heuft Hans-Gert , Apfelbacher Christian 
Published: April 2023

PurposeThe SeMaCo study (Serologische Untersuchungen bei Blutspendern des Großraums Magdeburg auf Antikörper gegen SARS-CoV-2), a prospective, longitudinal cohort study with four survey phases spanning 3–5 months each over a period of 22 months, extends the spectrum of seroepidemiological studies in Germany. We present here a careful characterisation of the initial survey phase of the cohort to provide baseline data on infection incidence and obtained from questionnaires, focussing in particular on the attitude towards COVID-19 vaccinations, the vaccination success and the vaccination acceptance.ParticipantsA total of 2195 individual blood donors from the donor pool of the blood donation service of the University Hospital Magdeburg were enrolled in the initial survey phase from 20 January 2021 to 30 April 2021. 2138 participants gave sociodemographic/contact data (51.7% male, mean age 44 years) and 2082 participants answered the vaccination questionnaire.Findings to dateOut of 2195 participants with antibody results, 1909 (87.0%) were antibody negative. The remaining 286 subjects (13.0%) were either antibody-positive and vaccinated (160/286; 55.9%) or antibody-positive without vaccination information (17/286; 5.9%) or antibody-positive and unvaccinated (109/286; 38.1%). The latter result reflects the rate of true or highly probable SARS-CoV-2 infections in our initial study cohort.Future plansThe study primarily aims to measure the prevalence and long-term kinetics of IgG-antibodies against SARS-CoV-2. Including the baseline, the study foresees four survey periods of 3–4 months each. At each visit, we will assess the blood donors’ attitude towards vaccination, the antibody response following vaccination and/or infection, as well as undesired vaccination effects. We aim to test the same participants during the survey periods by repeated invitations for blood donation to ensure a long-term (follow-up) in as many study participants as possible. After the four survey phases, a longitudinal data set will be created that reflects the course of the antibody levels/frequencies as well as the infection and vaccination incidence.Trial registration numberDRKS00023263.