bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Dose Naltrexone use for the management of post-acute sequelae of COVID-19
Authors: Bonilla Hector , Tian Lu , Marconi Vincent C. , Shafer Robert , McComsey Grace A. , Miglis Mitchel , Yang Philip , Geng Linda N. 
Published: June 2023

AbstractPost-Acute Sequelae of SARS-CoV-2 (PASC), also known as Long COVID, is globally estimated to have affected up to 40-50% of individuals who were infected with SARS-CoV-2. The causes of PASC are being investigated, and there are no established therapies. One of the leading hypotheses for the cause of PASC is the persistent activation of innate immune cells with increased systemic inflammation. Naltrexone is a medication with anti-inflammatory and immunomodulatory properties that has been used in other conditions that overlap with PASC. In this study we performed retrospective review of a clinical cohort of 59 patients at a single academic center who received low-dose naltrexone (LDN) off-label as a potential therapeutic intervention for PASC. The use of LDN was associated with improved clinical symptoms (fatigue, brain fog, post exertional malaise/PEM, unrefreshing sleep, sleep pattern, and headache), fewer number of symptoms, and better functional status. This observational finding warrants further testing in rigorous, randomized, placebo-controlled clinical trials.Highlights-The off-label use of low-dose naltrexone is a promising drug intervention candidate for the management of post-COVID conditions.-Low-dose naltrexone has anti-inflammatory and immunomodulatory properties which may benefit those with PASC where persistent inflammation is the causative pathway.-This potential benefit of LDN warrants further testing in rigorous randomized, placebo-controlled clinical trials.
Sustainability Indexes as Possible Predictors of Excess Mortality across OECD Countries during the Covid-19 Pandemic
Authors: Liu Lee 
Published: June 2023

AbstractThis study considered the Sustainable Development Goals (SDG) Index, Human Development Index (HDI), and Environmental Performance Index (EPI) as sustainability indexes and explored their potential effectiveness as predictors of Covid-19 excess mortality among countries in the Organization for Economic Cooperation and Development (OECD). The results indicated strong negative correlations between each index and Covid-19 excess mortality. Each of the indexes was able to consistently predict variations in excess mortality in the regression models. Such findings contribute to the current discussion on what lessons we should take away from the Covid-19 pandemic, specifically whether sustainability indexes may be useful in assessing Covid-19 outcomes. It is valuable to further examine the role sustainable policies and practices can play in preparing for future crises, as it has been demonstrated that social, economic, and environmental factors influenced the ability of a country to mitigate the impact of Covid-19. Overall, the most effective way for a country to both prevent and prepare for the next crisis is to improve health, education, and standard of living for its people, protect the environment, and achieve sustainability.
Select EZH2 inhibitors enhance the viral mimicry effects of DNMT inhibition through a mechanism involving calcium-calcineurin-NFAT signaling
Authors: Chomiak Alison A. , Tiedemann Rochelle L. , Liu Yanqing , Kong Xiangqian , Cui Ying , Thurlow Kate , Cornett Evan M. , Topper Michael J. , Baylin Stephen B. , Rothbart Scott B. 
Published: June 2023

AbstractDNA methyltransferase (DNMT) inhibitors are FDA-approved for various hematological malignancies but have limited efficacy in solid tumors. DNA hypomethylation with these drugs is associated with elevated lysine 27 tri-methylation on histone H3 (H3K27me3). We hypothesized that this EZH2-dependent repressive mark limits the full potential of DNMT inhibition. Here, we show in cell line and tumoroid models of colorectal cancer, that low-dose DNMT inhibition sensitizes cells to selective EZH2 inhibitors that have limited single agent toxicity, and that EZH2 inhibition enhances DNMT inhibitor-driven molecular and therapeutic effects. Through integrative epigenomic analyses, we reveal that DNMT inhibition induces H3K27me3 accumulation at genomic regions poised with EZH2. Unexpectedly, combined treatment alters the epigenome landscape to promote transcriptional upregulation of the calcium-calcineurin-NFAT signaling pathway. Blocking this pathway limits the transcriptional activating effects of the drug combination, including expression of transposable elements and innate immune response genes within a viral defense pathway. Consistently, we demonstrate positive correlations between DNMT inhibitor- and innate immune response-associated transcription profiles and calcium signal activation in primary human colon cancer specimens. Collectively, our study demonstrates that compensatory EZH2 activity following DNA hypomethylation presents a barrier to the therapeutic action of DNMT inhibition in colon cancer, reveals a new application of EZH2 inhibitors beyond cancers associated with PRC2 hyperactivity, and links calcium-calcineurin-NFAT signaling to epigenetic therapy-induced viral mimicry.HighlightsSelect EZH2 inhibitors enhance the transcriptional activating and antiproliferative effects of DNA hypomethylating agents in colon cancer cells.The mechanism involves blockade of H3K27me3 accumulation in regions of the genome poised for PRC2 activity.DNMT inhibitor + EZH2 inhibitor treatment transcriptionally upregulates calcium-calcineurin- NFAT signaling, and this pathway is necessary for complete induction of viral mimicry and innate immune response pathways.The therapeutic utility of EZH2 inhibitors may be extended beyond cancers with PRC2 hyperactivity in combination regimens with DNMT inhibitors.
cProSite: A web based interactive platform for online proteomics, phosphoproteomics, and genomics data analysis
Authors: Wang Dunrui , Qian Xiaolan , Du Yi-Chieh Nancy , Sanchez-Solana Beatriz , Chen Kailing , Kanigicherla Madhu , Jenkins Lisa M. , Luo Jason , Eng Sarah , Park Brian , Chen Ben , Yao Xiaozheng , Nguyen Thuong , Tripathi Brajendra K. , Durkin Marian E. , Lowy Douglas R. 
Published: June 2023

AbstractWe developed cProSite, a website that provides online genomics, proteomics, and phosphoproteomics analysis for the data of The National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium (CPTAC). This tool focuses on comparisons and correlations between different proteins and mRNAs of tumors and normal tissues. Our website is designed with biologists and clinicians in mind, with a user-friendly environment and fast search engine. The search results of cProSite can be used for clinical data validation and provide useful strategic information to identify drug targets at proteomic, phosphoproteomic, or genomic levels. The site is available athttp://cprosite.ccr.cancer.gov.SignificanceAn interactive database for the expression and correlation for proteins, proteomic phosphorylations, and mRNA levels has been developed for analyzing the molecular alterations between tumors and normal tissues of various tumor types.
Repository of logically consistent real-world Boolean network models
Authors: Pastva Samuel , Šafránek David , Beneš Nikola , Brim Luboš , Henzinger Thomas 
Published: June 2023

ABSTRACTRecent developments in both computational analysis and data-driven synthesis enable a new era of automated reasoning with logical models (Boolean networks in particular) in systems biology. However, these advancements also motivate an increased focus on quality control and performance comparisons between tools.At the moment, to illustrate real-world applicability, authors typically test their approaches on small sets of manually curated models that are inherently limited in scope. This further complicates reuse and comparisons, because benchmark models often contain ad hoc modifications or are outright not available.In this paper, we describe a new, comprehensive, open source dataset of 210+ Boolean network models compiled from available databases and a literature survey. The models are available in a wide range of formats. Furthermore, the dataset is accompanied by a validation pipeline that ensures the integrity and logical consistency of each model. Using this pipeline, we identified and repaired 400+ potential problems in a number of widely used models.
Interleukin-27-induced HIV-resistant dendritic cells suppress reveres transcription following virus entry in an SPTBN1, Autophagy, and YB-1 independent manner
Authors: Imamichi Tomozumi , Chen Qian , Sowrirajan Bharatwaj , Yang Jun , Laverdure Sylvain , Mele Anthony R. , Watkins Catherine , Adelsberger Joseph W. , Higgins Jeanette , Sui Hongyan 
Published: June 2023

AbstractInterleukin (IL)-27, a member of the IL-12 family of cytokines, induces human immunodeficiency virus (HIV)-resistant monocyte-derived macrophages and T cells. This resistance is mediated via the downregulation of spectrin beta, non-erythrocytic 1 (SPTBN1), induction of autophagy, or suppression of the acetylation of Y-box binding protein-1 (YB-1); however, the role of IL-27 administration during the induction of immature monocyte-derived dendritic cells (iDC) is poorly investigated. In the current study, we investigated the function of IL-27-induced iDC (27DC) on HIV infection. 27DC inhibited HIV infection by 95 ± 3 % without significant changes in the expression of CD4, CCR5, and SPTBN1 expression, autophagy induction and acetylation of YB-1 compared to iDC. An HIV proviral DNA copy number assay displayed that 27DC suppressed reverse transcriptase (RT) reaction without influencing the virus entry. A DNA microarray analysis was performed to identify the differentially expressed genes between 27DC and iDC. Compared to iDC, 51 genes were differentially expressed in 27DC, with more than 3-fold changes in four independent donors. Cross-reference analysis with the reported 2,214 HIV regulatory host genes identified nine genes as potential interests: Ankyrin repeat domain 22, Guanylate binding protein (GBP)-1, -2, -4, -5, Stabilin 1, Serpin family G member 1 (SERPING1), Interferon alpha inducible protein 6, and Interferon-induced protein with tetratricopeptide repeats 3. A knock-down study using si-RNA failed to determine a key factor associated with the anti-HIV activity due to the induction of robust amounts of off-target effects. Overexpression of each protein in cells had no impact on HIV infection. Thus, we could not define the mechanism of the anti-HIV effect in 27DC. However, our findings indicated that IL-27 differentiates monocytes into HIV-resistant DC, and the inhibitory mechanism differs from IL-27-induced HIV-resistant macrophages and T cells.
Simulation of nonuniform transmission lines
Authors: Condon Marissa 
Published: June 2023

Purpose
The purpose of the paper is the simulation of nonuniform transmission lines.

Design/methodology/approach
The method involves a Magnus expansion and a numerical Laplace transform. The method involves a judicious arrangement of the governing equations so as to enable efficient simulation.

Findings
The results confirm an effective and efficient numerical solver for inclusion of nonuniform transmission lines in circuit simulation.

Originality/value
The work combines a Magnus expansion and numerical Laplace transform algorithm in a novel manner and applies the resultant algorithm for the effective and efficient simulation of nonuniform transmission lines.
Open access initiatives in European countries: analysis of trends and policies
Authors: Nazim Mohammad , Bhardwaj Raj Kumar 
Published: June 2023

Purpose
This paper aims to analyze open access (OA) scholarly publishing patterns as well as OA policies and mandates across European countries.

Design/methodology/approach
The study is based on a descriptive research approach using data from Web resources, directories and bibliographic and citation databases, namely, DOAJ, OpenDOAR, SCImago journal and Country Ranking portal, ROARMAP and Web of Science.

Findings
The findings indicate that the initiatives and measures in Europe that promote OA are adequate. OA journals and digital repositories have progressively increased over the past two decades. Of the total journals (n = 25,231) published worldwide and indexed in Scopus, 53% are published in European countries, with 23.7% being OA journals. In total, 34% of the OA repositories (n = 5,714) are in European countries. The proportion of OA journal papers has grown significantly in all European countries, with a 14.3% annual growth rate. The average proportion of OA publications in European countries is significantly higher (39.07%) than the world average (30.16%), with a clear inclination for making research literature openly accessible via the green OA route (79.41%) compared to the gold OA route (52.30%). Most European research funders and institutions have required researchers to make OA available for their research findings, either by publishing them in OA journals or depositing accepted manuscripts in repositories.

Research limitations/implications
The study analyzed OA trends in Europe; other continents and countries were not included in the analysis. The study only described OA policies and mandates; the extent to which the OA policies and mandates were implemented was not studied. However, the results of the study may be helpful to policymakers, funders, research institutions and universities in other countries in adopting and implementing OA policies and mandates.

Originality/value
To the best of the authors’ knowledge, the study is the first that used multiple data sources for investigating different facets of OA publishing in European countries, including OA journals, digital repositories, research output, mandates and policies for publicly funded research. The findings will be helpful for researchers and policymakers interested in promoting OA adoption among researchers worldwide.
Impact of information consistency in online reviews on consumer behavior in the e-commerce industry: a text mining approach
Authors: Li Qinglong , Park Jaeseung , Kim Jaekyeong 
Published: June 2023

PurposeThe current study investigates the impact on perceived review helpfulness of the simultaneous processing of information from multiple cues with various central and peripheral cue combinations based on the elaboration likelihood model (ELM). Thus, the current study develops and tests hypotheses by analyzing real-world review data with a text mining approach in e-commerce to investigate how information consistency (rating inconsistency, review consistency and text similarity) influences perceived helpfulness. Moreover, the role of product type is examined in online consumer reviews of perceived helpfulness.Design/methodology/approachThe current study collected 61,900 online reviews, including 600 products in six categories, from Amazon.com. Additionally, 51,927 reviews were filtered that received helpfulness votes, and then text mining and negative binomial regression were applied.FindingsThe current study found that rating inconsistency and text similarity negatively affect perceived helpfulness and that review consistency positively affects perceived helpfulness. Moreover, peripheral cues (rating inconsistency) positively affect perceived helpfulness in reviews of experience goods rather than search goods. However, there is a lack of evidence to demonstrate the hypothesis that product types moderate the effectiveness of central cues (review consistency and text similarity) on perceived helpfulness.Originality/valuePrevious studies have mainly focused on numerical and textual factors to investigate the effect on perceived helpfulness. Additionally, previous studies have independently confirmed the factors that affect perceived helpfulness. The current study investigated how information consistency affects perceived helpfulness and found that various combinations of cues significantly affect perceived helpfulness. This result contributes to the review helpfulness and ELM literature by identifying the impact on perceived helpfulness from a comprehensive perspective of consumer review and information consistency.
Distrust of banks among the unbanked and banked
Authors: Grable John , Kwak Eun Jin , Archuleta Kristy 
Published: June 2023

PurposeThe purpose of this study was to explore the concept of distrust of traditional banking institutions as a factor that can explain the choice to remain unbanked in a marketplace that is designed to be financially inclusive.Design/methodology/approachEarning, spending, saving and borrowing data collected between May 2021 and February 2022 from 17,819 consumers living in the United States were used to examine the factors associated with distrust of banks. Using a conceptual framework borrowed from the health services profession, the study was conducted in two stages. At the first stage, distrust among the unbanked and banked was estimated using a Boruta-random forest algorithm. At the second stage of the analysis, a logit regression model was estimated to validate the variables identified in the Boruta-random forest analysis.FindingsResults from the analyses show that distrust of banks is multi-layered where being older, believing the country is heading in the wrong direction and being less confident in one's ability to obtain a personal loan in the amount of $1 to $999 are important factors related to distrust of banks among the unbanked.Research limitations/implicationsThis study shows how an ensemble machine learning technique based on a decision-tree methodology can be used to obtain unique insights into complicated data and large datasets within the bank marketing field.Originality/valueThe paper provides a discussion about ways domains of trust and specific variables can be utilized to address the persistent problem of financial exclusion in the United States. Implications for bankers, researchers, educators and policymakers are provided.
Building national disaster resilience: assessment of ENSO-driven disasters in Peru
Authors: Espinoza Vigil Alain Jorge , Booker Julian David 
Published: June 2023

Purpose
Societies go through complex challenges in the face of the vertiginous increase in disasters, mostly produced by the effects of extreme events. The lack of capacity to deal with disasters is evident, especially in developing countries, as in the case of Peru. Under such a premise, this paper contributes to strengthening the country’s capacities, through an evaluation of national disaster resilience to the El Niño-Southern Oscillation-driven hazards caused by the El Niño disaster event between 2016 and 2017 on the Peruvian coast.

Design/methodology/approach
By reviewing the literature, various hazards were identified, such as heavy rainfalls and cascading hazards, such as floods and landslides. Even though risk assessments were carried out, 169 people died and essential infrastructure was severely impacted and lost. Through a 12-criteria resilience assessment framework sub-divided into sustainable development and disaster risk reduction, a diagnosis of national disaster resilience was carried out, along with a disaster risk management evaluation. Under such assessments, strategic recommendations were proposed to enhance the resilience of the country.

Findings
The lack of resilience of the country is reflected in the evaluated criteria, the most negative being the built environment due to infrastructure system’s vulnerability to hazards, and the lack of social development, despite national economic growth in Peru.

Originality/value
The research is extremely valuable because it bridges the knowledge gap on disaster resilience in Peru. In addition, the methodology, as well as the multi-topic assessment framework, can be used for other analyses, which are key to building greater capacity in nations around the globe.
Historical prevalence of infectious diseases and gender equality in 122 countries
Authors: Ombolo Messono Omang , Asongu Simplice , Tchamyou Vanessa 
Published: June 2023

Purpose
This study aims to examine the effects of the historical prevalence of infectious diseases on contemporary gender equality. Previous studies reveal the persistence of the effects of historical diseases on innovation, through the channel of culture.

Design/methodology/approach
Drawing on the parasite stress theory, the authors propose a framework which argues that historical prevalence of infectious disease reduces contemporary gender equality. The study uses ordinary least squares and two-stage least squares in a cross-section with data from 122 countries between 2000 and 2021.

Findings
This study provide support for the underlying hypothesis. Past diseases reduce gender equality both directly and indirectly. The strongest indirect effects occur through innovation output. Gender equality analysis may take these findings into account and incorporate disease pathogens into the design of international social policy.

Originality/value
This study complements the extant literature by assessing the nexus between historical prevalence of infectious diseases and gender equality.
A step toward nurturing infrastructure sustainability and rating systems through construction management curricula
Authors: Rahat Rubaya , Pradhananga Piyush , ElZomor Mohamed 
Published: June 2023

Purpose
With the increasing demand for sustainable developments, higher education should focus on teaching both sustainable buildings and infrastructure systems. This study aims to investigate the existing sustainable infrastructure (SI) teaching efforts in sustainability courses; identify best practices to integrate SI throughout bachelor’s and master’s programs under the construction management (CM) curricula; and propose guidelines for students to obtain Envision sustainability professional (ENV SP) credential during sustainability education.

Design/methodology/approach
This study conducted keywords search within the sustainability course descriptions under the American Council for Construction Education accredited CM curricula to locate SI topics. Additionally, this research collected inputs from the Envision Academic Committee members to develop a matrix representing the best practices for integrating SI in higher education and provided a guide with a step-by-step procedure to obtain ENV SP credentials.

Findings
This study identified a gap regarding the availability of SI education and offered best practices on how CM curricula might nurture such knowledge. Phase I highlighted that only two CM programs taught infrastructure sustainability, and three programs offered sustainability credentialing processes under a bachelor’s degree. Phase II developed a framework that offered a variety of pedagogical approaches and outlined the process for obtaining the ENV SP certificate for CM students in the freshman, sophomore, junior and senior years.

Originality/value
The findings of this study can facilitate CM education to create awareness among the future workforce and encourage them to establish skills pertaining to the economic, social and environmental implications while designing SI.