bluuebunny/crossref_metadata_2025_split huggingface dataset:
ESIPT‐Active Pyrene‐imidazole Fluorophores: GSIPT, Dual Solid‐ and Solution‐State Emission plus Counter‐Intuitive Crystal Packing**
Authors: Venkatareddy Vinutha K. , Kumar Manish , Singh Vijay Pal , Malakalapalli Rajeswara Rao 
Published: July 2023

AbstractWe report a new excited‐state intramolecular proton transfer (ESIPT)‐inspired hydroxyl (OH)‐substituted pyrene‐imidazole that promote unprecedented intramolecular proton transfer in the ground state (GSIPT). The enol and keto isomers are in equilibrium, with a high keto‐isomer component in the solid state. In conjunction with DFT calculations, the photophysical studies and crystal structure analysis shred substantial evidence for the ground state transformation. The ESIPT‐active compounds also show the rare feature of high dual solution (φf=70 %) and solid state (φf=41 %) emission characteristics and counter‐intuitive stronger intermolecular interactions in the solid state versus the ESIPT‐inactive counterparts.
Robustness improvement model predictive control strategy based on Luenberger observer for Y‐type modular multilevel converter
Authors: Yue Bingyan , Cheng Qiming , Cheng Yinman 
Published: July 2023

SummaryThe Y‐type modular multilevel converter (Y‐MMC) has high reliability due to its high modularity. It can promise AC/AC conversion for high‐voltage and large‐capacity fractional frequency transmission systems (FFTS). The Y‐MMC under linear control has a poor ability to adapt to changing working conditions, resulting in unstable transmission, slow response, and large harmonics and overshoot. The Robustness Improvement Model Predictive Control strategy (RI‐MPC) for Y‐MMC under nonideal conditions is presented in this paper to enhance robustness under unbalanced conditions and adaptability to load changes. It points out that the conventional MPC has low robustness when Y‐MMC encounters parameters difference due to faulty line, designs an improved outer‐loop PI control to enhance robustness to provide an excellent reference value for the inner‐loop current, combines the Luenberger observer with MPC and limits the parameters with Jury criterion to improve stability, and uses a two‐step prediction to compensate for delay and reduce harmonics. Through software simulation and hardware experiments, it is proved that compared with the traditional PI and MPC method, the RI‐MPC method is more robust, faster, and has application value.
Strategy on precision medicine multidisciplinary team in clinical practice
Authors: Qian Mengjia , Zhan Yanxia , Ji Lili , Cheng Yunfeng 
Published: July 2023

AbstractBackgroundThe multidisciplinary team (MDT) of precision medicine refers to an expert group composed of experts from multiple disciplines, which uses the concept of precision medicine to regularly discuss related diseases, in order to solve difficult clinical problems and put forward feasible personalized treatment schemes for patients.Methods and resultsThe composition and function of precision medicine MDT is defined based on our clinical practice. MDT consists of core fixed members, extended members, auxiliary personnel and secretary. The overall workflow of MDT includes patient selection, organization, discussion and follow‐up. Under this workflow, our MDT team handled many cases, and some of them have been reported.ConclusionWe focused on the strategy analysis on multidisciplinary team of precision medicine including composition, function, management, and criteria, hoping to provide a novel and standardized treatment mode for patients.
Life‐history traits of a tropical bagrid catfish, Mystus mysticetus Roberts, 1992, caught from the Mekong Delta, Vietnam
Authors: Phan Thu Quynh , Vo Lam Thi Thao , Tran Anh Ngoc , Dinh Quang Minh 
Published: July 2023

AbstractPopulation's biological parameters, including length at first capture, mortalities, exploitation rates, growth coefficient, longevity, and recruitment times, are essential in assessing fishing status, but there is no data on Mystus mysticetus. Therefore, the study was conducted to provide these parameters to assess the fishing status of this species at Cai Rang, Can Tho (CRCT) and Long Phu, Soc Trang (LPST). A collection of 741 individual fish was used for analysis and showed that most fish size groups ranged from 9.0 cm to 12.0 cm, and the asymptotic length was 16.8 cm for both CRCT and LPST populations. The fish population von Bertalanffy curve was Lt = 16.80(1 − e−0.51(t + 0.38)) at CRCT and Lt = 16.80(1 − e−0.48(t + 0.40)) at LPST. The fish growth coefficient at CRCT (2.16) was higher than at LPST (2.13), whereas the reverse case was true for longevity ranging from 5.88 years (at CRCT) to 6.25 years (at LPST). At CRCT, fishing mortality, natural mortality, total mortality, and exploitation rate were 0.69/year, 1.40/year, 2.09/year, and 0.33, respectively; at LPST, these values were 0.75/year, 1.33/year, 2.08/year, and 0.36, respectively. Although the population parameter of this fish species exhibited a spatial variation, both CRCT and LPST fish resources have not been subjected to overexploit because E (0.33 at CRCT and 0.36 at LPST) is lower than E0.1 (0.707 at CRCT and 0.616 at LPST).
Effects of forest management on native bee biodiversity under the tallest trees in the world
Authors: Ealy Nya , Pawelek Jaime , Hazlehurst Jenny 
Published: July 2023

AbstractIt is not clear if mature secondary growth coniferous forests can support similar pollinator communities as old growth coniferous forests, or how active management (e.g., retention forestry) in mature secondary growth forests may affect pollinator communities. We compare the native bee community and plant‐bee interaction networks of old growth, naturally regenerating and actively managed (retention forestry) mature secondary growth forests of similar stand age. Old growth forests had a higher bee species richness and Shannon's diversity index, but not Simpson's diversity index, than both actively managed and naturally regenerating mature secondary forests. Forest type (old‐growth, naturally regenerating mature secondary growth, and actively managed mature secondary growth) had a significant effect on bee community composition. Redwood forest bee‐plant interaction networks were small in size and had lower complexity than expected and few connector species. While studies suggest that small‐scale timber harvest may increase bee biodiversity in the short‐term in other coniferous forest habitats, our study suggests that there may be long‐term negative effects of clear‐cutting that lower bee biodiversity in mature secondary growth forests as compared to mature old‐growth forests.
Joint species distribution models with imperfect detection for high‐dimensional spatial data
Authors: Doser Jeffrey W. , Finley Andrew O. , Banerjee Sudipto 
Published: July 2023

AbstractDetermining the spatial distributions of species and communities is a key task in ecology and conservation efforts. Joint species distribution models are a fundamental tool in community ecology that use multi‐species detection–nondetection data to estimate species distributions and biodiversity metrics. The analysis of such data is complicated by residual correlations between species, imperfect detection, and spatial autocorrelation. While many methods exist to accommodate each of these complexities, there are few examples in the literature that address and explore all three complexities simultaneously. Here we developed a spatial factor multi‐species occupancy model to explicitly account for species correlations, imperfect detection, and spatial autocorrelation. The proposed model uses a spatial factor dimension reduction approach and Nearest Neighbor Gaussian Processes to ensure computational efficiency for data sets with both a large number of species (e.g., >100) and spatial locations (e.g., 100,000). We compared the proposed model performance to five alternative models, each addressing a subset of the three complexities. We implemented the proposed and alternative models in the spOccupancy software, designed to facilitate application via an accessible, well documented, and open‐source R package. Using simulations, we found that ignoring the three complexities when present leads to inferior model predictive performance, and the impacts of failing to account for one or more complexities will depend on the objectives of a given study. Using a case study on 98 bird species across the continental US, the spatial factor multi‐species occupancy model had the highest predictive performance among the alternative models. Our proposed framework, together with its implementation in spOccupancy, serves as a user‐friendly tool to understand spatial variation in species distributions and biodiversity while addressing common complexities in multi‐species detection–nondetection data.
Efficacy of ivabradine in heart failure patients with a high‐risk profile (analysis from the SHIFT trial)
Authors: Abdin Amr , Komajda Michel , Borer Jeffrey S. , Ford Ian , Tavazzi Luigi , Batailler Cécile , Swedberg Karl , Rosano Giuseppe M.C. , Mahfoud Felix , Böhm Michael ,   the SHIFT Investigators
Published: July 2023

AbstractAimsEarly start and patient profile‐oriented heart failure (HF) management has been recommended. In this post hoc analysis from the SHIFT trial, we analysed the treatment effects of ivabradine in HF patients with systolic blood pressure (SBP) < 110 mmHg, resting heart rate (RHR) ≥ 75 b.p.m., left ventricular ejection fraction (LVEF) ≤ 25%, New York Heart Association (NYHA) Class III/IV, and their combination.Methods and resultsThe SHIFT trial enrolled 6505 patients (LVEF ≤ 35% and RHR ≥ 70 b.p.m.), randomized to ivabradine or placebo on the background of guideline‐defined standard care. Compared with placebo, ivabradine was associated with a similar relative risk reduction of the primary endpoint (cardiovascular death or HF hospitalization) in patients with SBP < 110 and ≥110 mmHg [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.74–1.08 vs. HR 0.80, 95% CI 0.72–0.89, P interaction = 0.34], LVEF ≤ 25% and >25% (HR 0.85, 95% CI 0.72–1.01 vs. HR 0.80, 95% CI 0.71–0.90, P interaction = 0.53), and NYHA III–IV and II (HR 0.83, 95% CI 0.74–0.94 vs. HR 0.81, 95% CI 0.69–0.94, P interaction = 0.79). The effect was more pronounced in patients with RHR ≥ 75 compared with <75 (HR 0.76, 95% CI 0.68–0.85 vs. HR 0.97, 95% CI 0.81–0.1.16, P interaction = 0.02). When combining these profiling parameters, treatment with ivabradine was also associated with risk reductions comparable with patients with low‐risk profiles for the primary endpoint (relative risk reduction 29%), cardiovascular death (11%), HF death (49%), and HF hospitalization (38%; all P values for interaction: 0.40). No safety concerns were observed between study groups.ConclusionsOur analysis shows that RHR reduction with ivabradine is effective and improves clinical outcomes in HF patients across various risk indicators such as low SBP, high RHR, low LVEF, and high NYHA class to a similar extent and without safety concern.
The isolation and characterization of lipid compounds from black soldier fly larvae
Authors: Okwuosa Raissa , Mabusela Wilfred T. , Missengue Roland N. M. , Petrik Leslie F. 
Published: July 2023

AbstractWith the global demand for lipid compounds on the rise, concerns are growing about the environmental and economic impact of traditional lipid sources. This concern is exacerbated by the ever‐increasing demand for plant‐based lipids, which is contributing to unsustainable production practices and competition for land and food. Considering this challenge, this work aimed at exploring the potential of black soldier fly larvae (BSFL) as a low‐cost and ecofriendly source of lipid classes. A fractionation scheme consisting of a mixture of polar and nonpolar solvents at different ratios was employed to isolate the lipid classes from BSFL oil using silica gel column chromatography, which is a conventional method of chromatography. The fraction's separation efficiency was validated using thin‐layer chromatography and characterized with Fourier‐transformed infrared spectroscopy and gas chromatography flame ionization (GC‐FID). Triglycerides (30%) were found to be the most abundant component while cholesterols (0.6%) were the least abundant lipid fractions in the lipid mixture. GC‐FID in the various lipid fractions analyzed, lauric acid exhibited the highest percentage among the triglycerides (16.64%), diglycerides (19.10%), monoglycerides (22.70%), and free fatty acids (27.65%) fractions. The fractionation scheme proposed achieves high efficiency in separating and recovering different lipid classes extracted from the BSFL.
New records of five Verrucaria species (Verrucariacaea, Ascomycota) from Iran
Authors: Kamyabi A. Saleh , Iranbakhsh Alireza , Moniri Mahroo H. , Asri Yunes 
Published: July 2023

AbstractThis study focused on the taxonomic evaluation of the genus Verrucaria Shrad (Ascomycota, Verrucariaceae) in northeast Iran. Lichen samples were collected from the Khorasan Razavi province and their morphological, anatomical, and ecological characteristics were investigated. According to the result, the species Verrucaria ahtii Pykälä, Launis and Myllys, Verrucaria cataleptoides (Nyl.) Nyl., Verrucaria dolosa Hepp., Verrucaria hochstetteri Fr., and Verrucaria muralis Ach., are new records from Iran.
Microbiological quality assessment of fresh produce: Potential health risk to children and urgent need for improved food safety in school feeding schemes
Authors: Msimango Thabang , Duvenage Stacey , Du Plessis Erika M. , Korsten Lise 
Published: July 2023

AbstractAbout 388 million school‐going children worldwide benefit from school feeding schemes, which make use of fresh produce to prepare meals. Fresh produce including leafy greens and other vegetables were served at 37% and 31% of school feeding programs, respectively, in Africa. This study aimed at assessing the microbiological quality of fresh produce grown onsite or supplied to South African schools that are part of the national school feeding programs that benefit over 9 million school‐going children. Coliforms, Escherichia coli, Enterobacteriaceae, and Staphylococcus aureus were enumerated from fresh produce (n = 321) samples. The occurrence of E. coli, Listeria monocytogenes, Salmonella spp., and extended‐spectrum β‐lactamase (ESBL)‐producing Enterobacteriaceae was determined. Presumptive pathogens were tested for antimicrobial resistance. E. coli was further tested for diarrheagenic virulence genes. Enterobacteriaceae on 62.5% of fresh produce samples (200/321) exceeded previous microbiological guidelines for ready‐to‐eat food, while 86% (276/321 samples) and 31.6% (101/321 samples) exceeded coliform and E. coli criteria, respectively. A total of 76 Enterobacteriaceae were isolated from fresh produce including E. coli (n = 43), Enterobacter spp. (n = 15), and Klebsiella spp. (n = 18). Extended‐spectrum β‐lactamase production was confirmed in 11 E. coli, 13 Enterobacter spp., and 17 Klebsiella spp. isolates. No diarrheagenic virulence genes were detected in E. coli isolates. However, multidrug resistance (MDR) was found in 60.5% (26/43) of the E. coli isolates, while all (100%; n = 41) of the confirmed ESBL and AmpC Enterobacteriaceae showed MDR. Our study indicates the reality of the potential health risk that contaminated fresh produce may pose to school‐going children, especially with the growing food safety challenges and antimicrobial resistance crisis globally. This also shows that improved food safety approaches to prevent foodborne illness and the spread of foodborne pathogens through the food served by school feeding schemes are necessary.
Limited clinical activity of palbociclib and ribociclib monotherapy in advanced cancers with cyclinD‐CDK4/6 pathway alterations in the DutchDRUPand AustralianMoSTtrials
Authors: Zeverijn Laurien J. , Looze Eleonora J. , Thavaneswaran Subotheni , van Berge Henegouwen J. Maxime , Simes Robert J. , Hoes Louisa R. , Sjoquist Katrin M. , van der Wijngaart Hanneke , Sebastian Lucille , Geurts Birgit S. , Lee Chee K. , de Wit Gijsbrecht F. , Espinoza David , Roepman Paul , Lin Frank P. , Jansen Anne M. L. , de Leng Wendy W. J. , van der Noort Vincent , Leek Lindsay V. M. , de Vos Filip Y. F. L. , van Herpen Carla M. L. , Gelderblom Hans , Verheul Henk M. W. , Thomas David M. , Voest Emile E. 
Published: July 2023

AbstractThe Dutch Drug Rediscovery Protocol (DRUP) and the Australian Cancer Molecular Screening and Therapeutic (MoST) Program are similar nonrandomized, multidrug, pan‐cancer trial platforms that aim to identify signals of clinical activity of molecularly matched targeted therapies or immunotherapies outside their approved indications. Here, we report results for advanced or metastatic cancer patients with tumors harboring cyclin D‐CDK4/6 pathway alterations treated with CDK4/6 inhibitors palbociclib or ribociclib. We included adult patients that had therapy‐refractory solid malignancies with the following alterations: amplifications ofCDK4,CDK6,CCND1,CCND2 or CCND3, or complete loss ofCDKN2A or SMARCA4. Within MoST, all patients were treated with palbociclib, whereas in DRUP, palbociclib and ribociclib were assigned to different cohorts (defined by tumor type and alteration). The primary endpoint for this combined analysis was clinical benefit, defined as confirmed objective response or stable disease ≥16 weeks. We treated 139 patients with a broad variety of tumor types; 116 with palbociclib and 23 with ribociclib. In 112 evaluable patients, the objective response rate was 0% and clinical benefit rate at 16 weeks was 15%. Median progression‐free survival was 4 months (95% CI: 3‐5 months), and median overall survival 5 months (95% CI: 4‐6 months). In conclusion, only limited clinical activity of palbociclib and ribociclib monotherapy in patients with pretreated cancers harboring cyclin D‐CDK4/6 pathway alterations was observed. Our findings indicate that monotherapy use of palbociclib or ribociclib is not recommended and that merging data of two similar precision oncology trials is feasible.
Diagnostic performance of routine blood parameters in periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome
Authors: Onur Hakan , Onur Arzu Rahmanali 
Published: July 2023

AbstractBackgroundWe aimed to investigate the difference between PFAPA and streptococcal tonsillitis (Strep Pharyngitis) by using blood parameters. We want to evaluate the relationship between periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome, and tonsillitis by using NLR.MethodsThe data of 141 pediatric patients who had applied to our clinic between October 2016 and March 2019 and were diagnosed with PFAPA syndrome and tonsillitis were reviewed from hospital records. The demographic data of the study group were recorded, as were their WBC, neutrophil, and lymphocyte counts, NLR, and MPV values, which are obtained by proportioning these two counts.ResultsCRP and ESR values were significantly higher in the PFAPA group (p = 0.026 and p < 0.001, respectively). No significant difference was determined between the groups in terms of platelet count or lymphocyte count. Receiver operating curve analyses were calculated. The AUC was 0.713 ± 0.04 according to age, and the CRP was 0.607 ± 0.04 (95% confidence interval). Using a cutoff point of >49 months for age, the sensitivity was 0.71 and the specificity was 0.67.ConclusionWith simple laboratory parameters, PFAPA syndrome can be differentiated from a diagnosis of tonsillitis. This may reduce the costs associated with unnecessary antibiotic use. However, these findings still need to be confirmed by other future studies.
Clinical value of prenatal ultrasound in diagnosis and classification of common arterial trunk
Authors: Su Xiao‐rong , Li Tian‐gang , Ma Bin , Wang Ai‐lin , Wei Chuan‐min , Tie Hong‐xia , Guo Wen‐jing 
Published: July 2023

AbstractObjectivesTo investigate the clinical value of prenatal ultrasound in the diagnosis of the common arterial trunk (CAT) classification and associated malformations.Materials and MethodsThe 2D ultrasound images, spatiotemporal image correlations (STICs) and clinical data of 88 fetuses diagnosed with CAT malformations by prenatal ultrasound were retrospectively analyzed and classified. The correlation between different types, fetal malformation and pregnancy outcomes were analyzed.ResultsAmong the 88 fetuses, there were 39 cases (44.32%) of type A1, 40 cases (45.45%) of type A2, 8 cases (9.09%) of type A3, and 1 case of type A4 (1.14%). There were 16 cases (18.18%) with isolated CAT, 48 cases (54.55%) with complex intra‐cardiac structural abnormalities, and 24 cases (27.27%) with intra‐cardiac and extra‐cardiac structural abnormalities. In extra‐cardiac structural malformations, 14 cases were associated with 1 other system abnormality, 4 cases with 2 other system abnormalities, 3 cases with 3 other system abnormalities, while 3 cases were combined with 4 other system abnormalities, among which the facial and physical abnormalities had the highest incidence (39.13%). The STIC images were completely displayed in all 88 cases. There was a statistical difference between isolated CAT and CAT combined with other abnormalities in fetal pregnancy outcomes.ConclusionsPrenatal ultrasound had a high clinical application value in CAT classification. Pregnancy outcomes were highly correlated with the classification and associated intra‐cardiac and extra‐cardiac structural malformations. The early evaluation of fetal prognosis before birth has important value for clinical intervention.
Artificial intelligence adoption among human resource professionals: Does market turbulence play a role?
Authors: Islam Md Asadul , Aldaihani Faraj Mazyed Faraj , Saatchi Seyed Ghasem 
Published: July 2023

AbstractDrawing from the Technology Acceptance Model (TAM) and Technology‐Organization‐Environment (TOE) framework, this study investigates the factors that influence the adoption of artificial intelligence (AI) among human resource (HR) professionals in the tourism organizations of Malaysia. Responses were collected from 389 HR employees working at tourism organizations. Based on a partial least squares‐structural equation modeling (PLS‐SEM) analysis, results revealed that perceived ease of use, perceived usefulness, technology competency, top management support, and competitive pressure have significantly positive impacts on AI adoption in the tourism industry in Malaysia. The study's contribution to the TAM and TOE models is the inclusion of market turbulence as a moderating factor, which has been found to be a significant moderator as it enhances the understanding of HR practitioners and others regarding the factors that are most influential in AI adoption among HR employees in the tourism industry. The model developed in this study highlights how market turbulence can foster the relationship between AI adoption and organizations. In addition to the managerial and theoretical implications, the study also discusses its limitations and outlines directions for future research.