bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy
Authors: Petov V. S. , Bazarkin A. K. , Krupinov E. S. , Morozov A. O. , Taratkin M. S. , Abdusalamov A. F. , Amosov A. V. , Enikeev D. V. 
Published: January 2023

Introduction. Transrectal biopsy under US-control has been standard diagnostic method for prostate cancer (PCa) detection for over 30 years. However, TRUS-guided biopsy is not without well-known drawbacks. MR-targeted biopsy methods were proposed to eliminate the drawbacks and improve detection rate of clinically significant Pca. Cognitive and mpMR/US-fusion biopsies have become the most widely used MR-targeted biopsies. However, there are contradictory data on detection of clinically significant Pca when comparing mpMR/US-fusion and cognitive biopsies.Objective. To compare the detection rate of clinically significant prostate cancer performing cognitive and mpMR/US-fusion biopsies.Materials and methods. Inclusion criteria: PSA > 2.0 ng/ml and/or a positive DRE, and/or a suspicious lesion on TRUS, and PI-RADSv2.1 score ≥ 3. The outcomes evaluated are the detection of clinically significant Pca (ISUP ≥ 2), the overall PСa detection, the detection of clinically insignificant Pca, histological yield (proportion of positive cores, maximum cancer core length).Results. Retrospective data analysis was performed: cognitive biopsy was performed in 102 patients and mpMR/US-fusion biopsy in 176 patients. The median age was 63 years, prostate volume 46 cc. The median PSA was 6.4 ng/ml in the mpMR/US-fusion and 6.7 ng/ml in the cognitive biopsy group. MpMR/US-fusion and cognitive biopsies were comparable about the detection rate of clinically significant (30.3% vs 25.0%; p=0.329) and overall Pca detection rate (50.5% and 42.1%; p = 0.176). It was detected to be less clinically insignificant Pca in the cognitive biopsy group (11.8% vs. 25.5%; p = 0.007). The proportion of positive cores (30.5% and 29.5% respectively; p = 0.754) and maximum cancer core length (6.6 mm vs 7.6 mm; p = 0.320) were equal when comparing cognitive and mpMR/US-fusion biopsies. The proportion of positive cores with clinically significant Pca was higher in the cognitive biopsy group (18.6% vs 13.1%; p = 0.029).Conclusion. Both cognitive and mpMR/US-fusion biopsies are equally accurate for clinically significant Pca detection. Therefore, cognitive biopsy may be an alternative to mpMR/US-fusion biopsy in hospitals where mpMR/US-fusion technology is not currently available.
Effect of taxanes on the miR-106 and miR-200c expression in prostate cancer cells in vivo and in vitro
Authors: Plevako D. S. , Knyazeva M. S. , Sidina E. I. , Berkut M. V. , Reva S. A. , Tolmachev S. S. , Artemyeva A. S. , Nosov A. K. , Malek A. V. 
Published: January 2023

Introduction. A combination of antiandrogen and cytostatic drugs was justified in the neoadjuvant therapy of patients with high-risk prostate cancer (HiRPCa) in some clinical trials. The effectiveness of such therapy in each individual case depends on the sensitivity of cancer cells to the applied drugs. It makes possible the development of the new technologies to personalize therapeutic approach. MicroRNAs (miRNAs) are a class of regulatory molecules whose expression is altered in PCa cells and can be associated with the sensitivity/resistance of cancer cells to specific cytostatics, for instance, taxanes.Objective. To identify the potential-marker miRNAs of PCa cells sensitivity to taxanes.Materials and methods. Samples of PCa tissue (n. 56) obtained from patients underwent neo-adjuvant therapy (antiandrogen and taxanes) and radical prostatectomy; PCa cell lines (PC-3, DU-145, LNCap). Total RNAs isolation was carried out using miRNeasy FFPE Kit, LRU-100-50; miRCURY LNA miRNA Focus PCR Panel, All-MIR kits were used for semi-quantitative analysis of potentially marker microRNA molecules using sequential reverse transcription and PCR.Results. The effect of taxanes on PCa cells is associated with up-regulation of miR-106b expression and down-regulation of miR-200c expression in both in vivo and in vitro conditions.Conclusion. MiR-106b and miR-200c miRNAs are involved in the response of PCa cells to taxanes, and therapeutic modification of these molecules in PCa cells may present a potential strategy to increase their sensitivity to taxane-containing therapy. Appropriate innovative technology may be in demand in the treatment of HiRPCa-patients.
The Impact of an Electronic Portal on Patient Encounters in Primary Care: Interrupted Time-Series Analysis
Authors: Ferguson Karen , Fraser Mark , Tuna Meltem , Bruntz Charles , Dahrouge Simone 
Published: January 2023

Background
Electronic patient portals are online applications that allow patients access to their own health information, a form of asynchronous virtual care. The long-term impact of portals on the use of traditional primary care services is unclear, but it is an important question at this juncture, when portals are being incorporated into many primary care practices.

Objective
We sought to investigate how an electronic patient portal affected the use of traditional, synchronous primary care services over a much longer time period than any existing studies and to assess the impact of portal messaging on clinicians’ workload.

Methods
We conducted a propensity-score–matched, open-cohort, interrupted time-series evaluation of a primary care portal from its implementation in 2010. We extracted information from the electronic medical record regarding age, sex, education, income, family health team enrollment, diagnoses at index date, and number of medications prescribed in the previous year. We also extracted the annual number of encounters for up to 8 years before and after the index date and provider time spent on secure messaging through the portal.

Results
A total of 7247 eligible portal patients and 7647 eligible potential controls were identified, with 3696 patients matched one to one. We found that portal registration was associated with an increase in the number of certain traditional encounters over the time period surrounding portal registration. Following the index year, there was a significant jump in annual number of visits to physicians in the portal arm (0.42 more visits/year vs control, P<.001) but not for visits to nurse practitioners and physician assistants. The annual number of calls to the practice triage nurses also showed a greater increase in the portal arm compared to the control arm after the index year (an additional 0.10 calls, P=.006). The average provider time spent on portal-related work was 5.7 minutes per patient per year.

Conclusions
We found that portal registration was associated with a subsequent increase in the number of some traditional encounters and an increase in clerical workload for providers. Portals have enormous potential to truly engage patients as partners in their own health care, but their impact on use of traditional health care services and clerical burden must also be considered when they are incorporated into primary care.
Dermatologists’ Perceptions of the Use of Teledermatology in Managing Hidradenitis Suppurativa: Survey Study
Authors: Long Valencia , Choi Ellie Ci-En , Chen Zhaojin , Kamil Moonyza Akmal Ahmad , Rajagopalan Murlidhar , McMeniman Erin , Chandran Nisha Suyien 
Published: January 2023

Background
The field of teledermatology has expanded tremendously and has been used for conditions including hidradenitis suppurativa (HS). However, due to the sensitive location of lesions, HS may be considered less suitable for teledermatology.

Objective
We sought to assess dermatologists’ experiences and perceptions toward using teledermatology for HS relative to atopic dermatitis (AD) as a comparison.

Methods
A survey was disseminated electronically to practicing dermatologists in the Asia-Pacific region between February and June 2022. Differences in attitudes and perceptions between HS and AD were compared using random-effects ordered logistic regression, controlling for demographics.

Results
A total of 100 responses were obtained comprising of 76 (81.7%) dermatologists and 17 (18.3%) dermatology trainees; 62.6% (62/98) of physicians were uncomfortable with using teledermatology for HS. Multivariable regression confirmed increased perceived challenges with managing HS using teledermatology compared to AD. These challenges include the need for photography of hard-to-reach or sensitive areas (odds ratio [OR] 4.71, 95% CI 2.44-9.07; P<.001), difficulties in accurate assessment of severity (OR 2.66, 95%CI 1.48-4.79; P=.001), and inability to palpate lesions (OR 2.27, 95% CI 1.23-4.18; P=.009).

Conclusions
This study confirms the relative reluctance of dermatologists to use teledermatology for HS and complements existing data showing mixed levels of willingness from patients. The use of teledermatology for HS may need to be optimized to overcome these challenges, including increasing security features, selection of patients with milder or limited diseases, and selecting patients with an established and strong doctor-patient relationship.
De neófitos, amancebados y fornicarios. Los nahuas y sus pecados en tres confersionarios tempranos
Authors: Alcántara Berenice 
Published: January 2023

Durante el periodo novohispano los confesionarios en lenguas indígenas fueron uno de los medios empleados por los evangelizadores para vigilar y adoctrinar a sus feligreses, y para inculcar en ellos nuevas formas de subjetividad cristianas. En este trabajo se comparan tres confesionarios en lengua náhuatl que han llegado hasta nosotros en distintos manuscritos y nunca antes habían sido traducidos ni analizados. La intención es mostrar el carácter temprano de estos textos y las distintas estrategias empleadas por los frailes, durante las primeras décadas del proceso de evangelización, para intentarconvertir a los nahuas en pecadores.
Rancang Bangun Aplikasi E-Commerce Berbasis Web Pada Toko UD. Nira Utama
Authors: Herfandi Herfandi , Syahwatullah Ari , Julkarnain M 
Published: January 2023

Toko UD. Nira Utama adalah sebuah badan usaha yang bergerak dibidang penjualan barang eletronik dan meubel. Dalam memasarkan barang, Toko UD. Nira Utama masih dilakukan dengan cara manual yaitu mulai dari proses promosi, proses pengelolaan data dan proses penjualan. Oleh kerena itu, peneliti melakukan penelitian untuk memberikan solusi alternatif terhadap permasalahan yang terjadi di Toko UD. Nira Utama berupa aplikasi E-Commerce. penelitian ini menggunakan metode Waterfall, permodelan desain program aplikasi menggunakan UML (Unified Modeling Language), serta menggunakan PHP sebagai bahasa pemograman dan MySQL sebagai database. Hasil Penelitian telah diterapkan untuk memecahkan permasalahan pada Toko UD. Nira Utama.
IMPLEMENTASI ALGORITMA RIVEST CODE (RC6) PADA APLIKASI KEAMANAN DATA SMS BERBASIS ANDROID
Authors: Sari Anggi Puspita , Mustika Muhammad Panca , Nasution Raudah , Gunawan Wawan 
Published: January 2023

SMS adalah teknologi untuk mengirim pesan. Pesan yang sifatnya rahasia dapat disadap oleh siapa saja karena pada saat pesan dikirimkan akan disimpan di SMSC (Short Message Service Center), yaitu tempat dimana SMS disimpan sebelum dikirim ke tujuan. Akibatnya pesan yang rahasia seperti nomor pin, password, kode akses, dan lain-lain dapat dibaca oleh pihak yang tidak berhak untuk mengetahuinya. Oleh karena itu, dengan menggunakan kriptografi memberikan jaminan keamanan data atau informasi dengan cara enkripsi dan dekripsi menggunakan algoritma Rivest Code (RC6). RC 6 dianggap cocok digunakan untuk aplikasi berbasis mobile karena selain sangat sederhana RC 6 juga mudah untuk diimplementasikan pada ponsel berbasis android, karena algoritma ini hanya membutuhkan memory yang kecil. Aplikasi yang dihasilkan menggunakan eclipse karena mudah dalam penggunaannya.
Manajemen Stress Pada Masa New Normal dalam Menumbuhkan Kesehatan Mental
Authors: Nihayah Ulin , Novita Dewi , Qurotal Aini Luk Luk , Qodli Agisna Asmara 
Published: January 2023

Mental health or what we know as mental health is a condition in which the mind of each individual is in a state of peace and calm, so that it will allow each individual to enjoy life that is lived daily and be able to appreciate other individuals who are around him around.
The purpose of making this journal is to find out stress management in the new normal period in growing mental health. This study was conducted to determine the extent to which the impact of COVID-19 which interferes with individual mental health has an impact on the stress experienced by many individuals. This study uses the method used in this study, namely using qualapriktive research methods with literature study data collection techniques. Which will discuss 7 national journals which all have something to do with mental health as a result of COVID-19
The effect of postprandial in vivo and experimental in vitro hyperlipidemia on human peripheral blood monocytes
Authors: Manescu Ion Bogdan , Manescu Mariuca , Preda Elena Cristina , Manu Doina Ramona , Dobreanu Minodora 
Published: January 2023

Abstract

Objective: In this study, we aimed to investigate the effect of transient postprandial in vivo and prolonged experimental in vitro hyperlipidemia on human peripheral blood monocytes. Methods: Peripheral blood was collected from seven healthy subjects after an overnight fast and three hours after a standardized high-fat meal. Both fasting and postprandial samples were stained for surface markers CD14/CD11b and intracellular lipids using BODIPY493/503. Postprandial samples only were used for isolation of peripheral blood mononuclear cells that were further incubated overnight with postprandial hyperlipidemic autologous plasma, then stained as described above. All samples were analyzed on a FACSAria III flow cytometer.

Results: Flow cytometric analysis revealed two monocyte populations (CD14+): CD14low and CD14high. In fasting, these populations show similar morphology (FSC/SSC), but different expressions of CD14, CD11b, and BODIPY493/503. At three hours postprandially, a moment of maximum hyperlipidemia, neither population suffered significant changes. After the 24-hour incubation, cell activation was observed in both populations: similar fold change increase in SSC, increase in FSC for CD14high cells only, similar foldchange increase in CD14, slightly higher foldchange increase in CD11b for CD14low monocytes, and significantly higher foldchange increase in lipid content for CD14high monocytes. CD14high monocytes appear to undergo a more intense activation than CD14low monocytes.

Conclusions: We conclude that all monocytes react after prolonged in vitro exposure to plasma lipids, each subset having its own activation pattern. All monocyte types may play a role in inflammation and the development of plaques. Monocyte assays are a valuable tool for the investigation of atherosclerosis at the cellular level.
Spatio-temporal variation on land use and land cover and its drivers under watershed management activities in Becho, Central Highlands of Ethiopia
Authors: Hailu Mahammed Endrias , Ahmed Mohammed Assen , Naji Temesgen Argaw 
Published: January 2023

Abstract
The study sought to understand the spatio-temporal variation of land use and land cover (LULC) and its drivers under watershed management activities in Becho district, in Ethiopia’s Central Highlands. To gain a better comprehension of the subject, two micro watersheds were chosen to test the effectiveness of watershed management activities (treated-Shankur Tareqo and untreated-Mende Tufessa). LULC changes were detected using aerial photography (1973), and satellite images from Landsat 5 TM (1990), Spot 5 (2005), and Landsat 8 OLI (2021) obtained from the Ethiopian Geospatial Information Institute and the United States Geological Survey. In addition, key informant interviews (KII) and focus group discussions (FGD) were used to elicit LULC drivers. Between 1973 and 2021, the total area of woodland, and cultivated and rural settlement land LULC classes in the treated micro-watershed decreased by 24.65% (171.9 ha) and 7.34% (759 ha), respectively. Though, grassland, forestland, and barrenland increased by 30.83% (179.52 ha), 1% (3 ha), and 183.14% (755.28 ha), respectively. The overall area of LULC class for woodland, grassland, forestland, and cultivated and rural settlement decreased by 50.36% (316.16 ha), 41.23% (196.46 ha), 2.43% (11.85 ha), and 1.35% (138.6 ha), respectively, in the untreated micro-watershed, while barrenland increased by 175.86% (666.55 ha). According to KII and FGD, the drivers of LULC changes were identified as the expansion of cultivated land, population pressure, and government policy. According to the findings, local-scale watershed management activities was not as effective as expected. As a result, in order to achieve the desired outcome, the concerned stakeholders should reconsider how watershed management activities is undertaken.
The Effectiveness of the Implementation of Research Results in a Technological Scheme of Water Purification
Authors: Galkina Olena , Kunytskyi Sergiy , Shevchenko Tamara 
Published: January 2023

Abstract
The paper proposes technical solutions for the use of the reagent method of water preparation at coke plants in order to bring it to a quality suitable for use in the circulating water supply system of the PJSC Kharkiv Coke Plan. It is proposed to dilute phenolic water in a biochemical installation in a mixer before purification and to purify water with a flocculant. The paper recommends dosing the flocculant solution automatically using a preparation station. Additional purification of the clarified water is carried out using a filtration unit with a filter media from a layer of quartz sand. The economic effect from the implementation of the technical measures is achieved not only due to the reduction in fresh water consumption by 60 540 m3/year and the cessation of the discharge of phenolic water into the city sewer network, but also the replacement of the reagent with a more efficient one and a decrease in its consumption. It has been found that the introduction of the technical solutions for the circulating water supply system is economically and environmentally justifiable.
Undergraduate student’s perception of online learning in English speaking class
Authors: Nabilla Cut Fatin , Komariah Endang , Mohd Jani Nur 'Ain Binti 
Published: January 2023

Student perception offers numerous information about students’ experiences in online courses, provides lecturers with valuable feedback, indicates how much students learn, and shows the quality of the teaching and learning process. The current study is aimed to find out the students’ perception of speaking class conducted online in terms of usefulness, effectiveness, and intentions. The questionnaires employed in this quantitative study were the students’ perceptions of the online speaking course, which were completed by 112 undergraduate EFL students. The descriptive statistics consisted of five number summary were used to analyze the data. The findings showed that the students had different perceptions about online learning for a speaking class. The students’ perceptions of the online speaking class are mostly positive in the terms of usefulness and effectiveness. However, most of the students did not have positive intention to enroll in online speaking class in the future. Therefore, lecturers are suggested to use interactive methods in delivering the learning material with the use of video conferences such as Zoom and Google Meet.
Kesalahan gramatikan pada teks terjemahan (Indonesia-Arab) siswa MA At-Taufiq Diwek Jombang
Authors: Ahya Akhmad Sauqi 
Published: January 2023

<p>Kesulitan mencari padanan dalam menerjemah merupakan permasalahan yang sulit di pecahkan dalam kajian ilmu terjemahan. Tujuan penelitian ini adalah menganalisis bentuk kesalahan gramatikal pada terjemahan Arab-Indonesia. Metode penelitian ini menggunakan deskriptif kualitatif berupa kata-kata yang ada dalam teks terjemahan siswa MA At-Taufiq. Sumber datanya berupa teks terjemahan yang dikumpulkan melalui teknik dokumentasi, kemudian dianalisis menggunakan teknik analisis interaktif. Pengidentifikasian tipe kesalahan, digunakan format analisis kesalahan bahasa yang mengelompokkan kesalahan berdasarkan taksonomi kategori linguistik yaitu kesalahan fonologis, morfologis, sintaksis dan leksikon. Identifikasi kesalahan juga didasarkan pada jenis-jenis kesalahan menurut Ellis. Ellis membagi kesalahan berbahasa menjadi empat jenis kesalahan yakni <em>Omission, Addition, Misformation, Misordering</em>. Temuan penelitian adalah, 1). penghilangan <em>Al- yang ditemukan pada dua teks terjemah siswa; 2) </em>Penghilangan <em>an masdariyah</em> yang <em>ditemukan pada enam teks terjemahan; </em>3) Kesalahan dalam kaidah penyusunan huruf; 4). Kesalahan bentuk deklinasi ditemukan pada lima teks terjemah; 6) kesalahan letak pola urutan sintaksis pada kaedah <em>Na’at Man’ut </em>dan <em>tamyiz </em>yang ditemukan pada tiga teks terjemahan.</p>
Productivity, quality and nutritional value of grain of Botanicheskaya 4 — the new spring triticale variety (×Triticosecale Wittm. ex. A. Camus)
Authors: О.А. Щуклина, , А.Д. Аленичева, , Е.В. Квитко, , И.В. Груздев, , И.Н. Клименкова, , С.В. Завгородний, , Ц.С. Гарибян, , А.А. Соловьёв, 
Published: January 2023

В статье представлены результаты конкурсного и экологического испытания в 2014–2022 годах нового сорта гексаплоидной (2n=42) яровой тритикале (×Triticosecale Wittm. ex. Camus) Ботаническая 4 в условиях дерново-подзолистых средне- и тяжелосуглинистых почв с низким уровнем гумуса. Индивидуальный отбор в гибридных питомниках и комплексное изучение гибридов по хозяйственно ценным признакам выполнены на Полевой опытной станции ФГБОУ ВО «РГАУ–МСХА им. К. А. Тимирязева», в отделе отдалённой гибридизации ФГБУН «Главный ботанический сад им. Н. В. Цицина РАН» (Московская область, Истринский район) и в лаборатории маркерной и геномной селекции ФГБНУ «Всероссийский научно-исследовательский институт сельскохозяйственной биотехнологии» (г. Москва). Результаты испытаний показали, что сорт в среднем имеет урожайность зерна 3,81 т/га, при увеличении уровня обеспеченности почвы азотом урожайность может составить до 7,2 т/га. Сорт отзывчив на подкормки азотными удобрениями и даёт прибавку урожайности зелёной массы от 11,7 до 14,4 т/га и от 3,0 до 3,6 т/га урожайности сухого вещества (в фазу колошения). Среднее содержание белка в зерне составило 11,5–13,5%, сухой клейковины — 15,2–21,6%. Масса 1000 семян в зависимости от уровня азотного питания составила от 35,6 до 42,7 г. Спектральный анализ зерна сорта Ботаническая 4 показал высокую кормовую ценность, превосходящую по некоторым показателям зерно других культур. Сорт прошёл испытания в Государственной комиссии по сортоиспытанию и был включён в Реестр селекционных достижений по Волго-Вятскому региону в 2022 году.