bluuebunny/crossref_metadata_2025_split huggingface dataset:
AFM‐Based Poroelastic@Membrane Analysis of Cells and its Opportunities for Translational Medicine
Authors: Ren Keli , Feng Jiantao , Bi Hai , Sun Quanmei , Li Xiang , Han Dong 
Published: July 2023

AbstractCell mechanics is an emerging field of research for translational medicine. Here, the cell is modeled as poroelastic cytoplasm wrapped by tensile membrane (poroelastic@membrane model) and is characterized by the atomic force microscopy (AFM). The parameters of cytoskeleton network modulus EC, cytoplasmic apparent viscosity ηC, and cytoplasmic diffusion coefficient DC are used to describe the mechanical behavior of cytoplasm, and membrane tension γ is used to evaluate the cell membrane. Poroelastic@membrane analysis of breast cells and urothelial cells show that non‐cancer cells and cancer cells have different distribution regions and distribution trends in the four‐dimensional space composed of EC, ηC. From non‐cancer to cancer cells, there is often a trend of γ, EC, ηC decreases and DC increases. Patients with urothelial carcinoma at different malignant stages can be distinguished at high sensitivity and specificity by analyzing the urothelial cells from tissue or urine. However, sampling directly from tumor tissues is an invasive method, may lead to undesirable consequences. Thus, AFM‐based poroelastic@membrane analysis of urothelial cells from urine may provide a non‐invasive and no‐bio‐label method to detecting urothelial carcinoma.
A Large‐Area Patterned Hydrogen‐Bonded Organic Framework Electrochromic Film and Device
Authors: Feng Jifei , Luo Yi , Wang Xinyi , Cai Guofa , Cao Rong 
Published: July 2023

AbstractFabrication of a patterned hydrogen‐bonded organic framework (HOF) films on a large scale is an extreme challenge. In this work, a large area HOF film (30 × 30 cm2) is prepared via an efficient and low‐cost electrostatic spray deposition (ESD) approach on the un‐modified conductive substrates directly. Combining the ESD with a template method, variously patterned HOF films can be easily produced, including deer‐ and horse‐shaped films. The obtained films exhibit excellent electrochromic performance with multicolor change from yellow to green and violet, and two‐band regulation at 550 and 830 nm. Benefiting from the inherently present channels of HOF materials and the additional film porosity created by ESD, the PFC‐1 film could quickly change color (within 10 s). Furthermore, the large‐area patterned EC device is constructed based on the above film to prove practical potential application. The presented ESD method can be extended to other HOF materials; thus, this work paves a feasible path for constructing large‐area patterned HOF films for practical optoelectronic applications.
Fluorine Passivation Inhibits “Particle Talking” Behaviors under Thermal and Electrical Conditions of Pure Blue Mixed Halide Perovskite Nanocrystals
Authors: Zhan Wenji , Liu Mingming , Wan Qun , He Mengda , Zhang Qinggang , Liao Xinrong , Yuan Changwei , Kong Long , Wang Yusheng , Sun Baoquan , Brovelli Sergio , Li Liang 
Published: July 2023

AbstractOwing to outstanding optoelectronic properties, lead halide perovskite nanocrystals (PNCs) are considered promising emitters for next‐generation displays. However, the development of pure blue (460‐470 nm) perovskite nanocrystal light‐emitting diodes (PNC‐LEDs), which correspond to the requirements of Rec. 2020 standard, lag far behind that of their green and red counterparts. Here, pure blue CsPb(Br/Cl)3 nanocrystals with remarkable optical performance are demonstrated by a facile fluorine passivation strategy. Prominently, the fluorine passivation on halide vacancies and strong bonding of Pb–F intensely enhance crystal structure stability and inhibit “particle talking” behaviors under both thermal and electrical conditions. Fluorine‐based PNCs with high resistance of luminescence thermal quenching retain 70% of photoluminescent intensity when heated to 343 K, which can be attributed to the elevated activation energy for carrier trapping and unchanged grain size. Fluorine‐based PNC‐LEDs also exhibit stable pure blue electroluminescence (EL) emission with sevenfold promoted luminance and external quantum efficiencies (EQEs), where the suppression of ion migration is further evidenced by a lateral structure device with applied polarizing potential.
tRNA‐derived RNAs: Biogenesis and roles in translational control
Authors: Akiyama Yasutoshi , Ivanov Pavel 
Published: July 2023

AbstractTransfer RNA (tRNA)‐derived RNAs (tDRs) are a class of small non‐coding RNAs that play important roles in different aspects of gene expression. These ubiquitous and heterogenous RNAs, which vary across different species and cell types, are proposed to regulate various biological processes. In this review, we will discuss aspects of their biogenesis, and specifically, their contribution into translational control. We will summarize diverse roles of tDRs and the molecular mechanisms underlying their functions in the regulation of protein synthesis and their impact on related events such as stress‐induced translational reprogramming.This article is categorized under:
RNA Processing > Processing of Small RNAs
Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs
Regulatory RNAs/RNAi/Riboswitches > Biogenesis of Effector Small RNAs
Modular invariance and the QCD angle
Authors: Feruglio Ferruccio , Strumia Alessandro , Titov Arsenii 
Published: July 2023

Abstract
String compactifications on an orbi-folded torus with complex structure give rise to chiral fermions, spontaneously broken CP, modular invariance. We show that this allows simple effective theories of flavour and CP where: i) the QCD angle vanishes; ii) the CKM phase is large; iii) quark and lepton masses and mixings can be reproduced up to order one coefficients. We implement such general paradigm in supersymmetry or supergravity, with modular forms or functions, with or without heavy colored states.
Correlating New Physics Effects in Semileptonic ∆C = 1 and ∆S = 1 Processes
Authors: Fajfer Svjetlana , Kamenik Jernej F. , Korajac Arman , Košnik Nejc 
Published: July 2023

Abstract
We present constraints on the left-handed dimension-6 interactions that contribute to semileptonic and leptonic decays of K, D, pions and to nuclear beta decay. We employ the flavour covariant description of the effective couplings, identify universal CP phases of New Physics and derive constraints from decay rates and CP-odd quantities. As a result, we can predict the maximal effects of such flavoured NP in D decays from stringent K decay constraints and vice-versa.
Search for the dipole portal of heavy neutral leptons at future colliders
Authors: Ovchynnikov Maksym , Zhu Jing-Yu 
Published: July 2023

Abstract
In this paper, we study the potential of future colliders to explore the parameter space of heavy neutral leptons (HNLs) through the dipole portal. We consider hadron colliders such as the LHC in the high luminosity phase and FCC-hh, and lepton colliders, such as FCC-ee. We consider various signatures for the HNLs, including the missing energy signature and displaced decays, and discuss the complementarity between the hadron and lepton colliders. We propose new selection rules which may significantly reduce the background events in FCC-ee. In particular, we find that thanks to a much clearer environment, FCC-ee may search for the HNLs with masses up to ≃ 30 GeV and proper lifetimes cτN ≳ 1 cm, which is well beyond the reach of the experiments to be launched in the next decade.
The holographic map of an evaporating black hole
Authors: Gyongyosi Zsolt , Hollowood Timothy J. , Kumar S. Prem , Legramandi Andrea , Talwar Neil 
Published: July 2023

Abstract
We construct a holographic map that takes the semi-classical state of an evaporating black hole and its Hawking radiation to a microscopic model that reflects the scrambling dynamics of the black hole. The microscopic model is given by a nested sequence of random unitaries, each one implementing a scrambling time step of the black hole evolution. Differently from other models, energy conservation and the thermal nature of the Hawking radiation are taken into account. We show that the QES formula follows for the entropy of multiple subsets of the radiation and black hole. We further show that a version of entanglement wedge reconstruction can be proved by computing suitable trace norms and quantum fidelities involving the action of a unitary on a subset of Hawking partners. If the Hawking partner is in an island, its unitary can be reconstructed by a unitary on the radiation. We also adopt a similar setup and analyse reconstruction of unitaries acting on an infalling system.
A nonabelian Brunn–Minkowski inequality
Authors: Jing Yifan , Tran Chieu-Minh , Zhang Ruixiang 
Published: July 2023

AbstractHenstock and Macbeath asked in 1953 whether the Brunn–Minkowski inequality can be generalized to nonabelian locally compact groups; questions along the same line were also asked by Hrushovski, McCrudden, and Tao. We obtain here such an inequality and prove that it is sharp for helix-free locally compact groups, which includes real linear algebraic groups, Nash groups, semisimple Lie groups with finite center, solvable Lie groups, etc. The proof follows an induction on dimension strategy; new ingredients include an understanding of the role played by maximal compact subgroups of Lie groups, a necessary modified form of the inequality which is also applicable to nonunimodular locally compact groups, and a proportionated averaging trick.
Änderungen des Arbeitsalltags und Moral Distress in der psychiatrischen Versorgung während der COVID-19-Pandemie
Authors: Guinaudeau Jeanne , Baier Paul Christian , Kühlmeyer Katja , Borzikowsky Christoph , Terheyden Laura , Witt Victoria Dorothea , Rogge Annette 
Published: July 2023

Zusammenfassung
Hintergrund
Während der COVID-19-Pandemie ist es zu besonderen moralischen Herausforderungen im Gesundheitswesen gekommen. Eine psychische Reaktion auf moralische Herausforderungen wird als Moral Distress (MD) bezeichnet.

Ziel der Arbeit
Identifikation von Ursachen für MD in der stationären psychiatrischen Versorgung im Kontext der COVID-19-Pandemie in Deutschland.

Material und Methoden
Es wurde eine Umfrage mit einem selbstadministrierten nichtvalidierten Onlinefragebogen als Querschnittserhebung durchgeführt, in dem 26 Items zum Erleben von MD untersucht sowie offene Fragen zum Umgang mit der Pandemie und Auswirkungen auf den Arbeitsalltag qualitativ ausgewertet wurden. Ärzt*innen, die in der stationären psychiatrischen Versorgung während der COVID-19-Pandemie in Deutschland tätig waren, wurden anonym mit einer Gelegenheitsstichprobe befragt. Die Erhebung fand vom 17.11.2020 bis 06.05.2021 statt.

Ergebnisse
Es wurden 141 Teilnehmer*innen eingeschlossen. Sie gaben vielfältige pandemiebedingte Veränderungen des Arbeitsalltages an, die teilweise in MD resultierten.

Diskussion
Moral Distress stellt für Ärzt*innen in der stationären psychiatrischen Versorgung unter Pandemiebedingungen (und darüber hinaus) einen potenziellen Belastungsfaktor dar, der weitere Forschung und einen angemessenen Umgang erfordert. Es ergeben sich sowohl Implikationen für Entscheidungstragende in Krisenstäben als auch ein Bedarf für Unterstützungsangebote z. B. durch Dienste zur klinischen Ethikberatung.
Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose–response data
Authors: Menz Jakob , Götz Mario E. , Gündel Ulrike , Gürtler Rainer , Herrmann Kristin , Hessel-Pras Stefanie , Kneuer Carsten , Kolrep Franziska , Nitzsche Dana , Pabel Ulrike , Sachse Benjamin , Schmeisser Sebastian , Schumacher David M. , Schwerdtle Tanja , Tralau Tewes , Zellmer Sebastian , Schäfer Bernd 
Published: July 2023

AbstractGenotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than a decade, there has been a discussion about the need for a paradigm shift in this regard. Here, we review current opportunities, challenges and perspectives for a more quantitative approach to genotoxicity assessment. Currently discussed opportunities mainly include the determination of a reference point (e.g., a benchmark dose) from genetic toxicity dose–response data, followed by calculation of a margin of exposure (MOE) or derivation of a health-based guidance value (HBGV). In addition to new opportunities, major challenges emerge with the quantitative interpretation of genotoxicity data. These are mainly rooted in the limited capability of standard in vivo genotoxicity testing methods to detect different types of genetic damage in multiple target tissues and the unknown quantitative relationships between measurable genotoxic effects and the probability of experiencing an adverse health outcome. In addition, with respect to DNA-reactive mutagens, the question arises whether the widely accepted assumption of a non-threshold dose–response relationship is at all compatible with the derivation of a HBGV. Therefore, at present, any quantitative genotoxicity assessment approach remains to be evaluated case-by-case. The quantitative interpretation of in vivo genotoxicity data for prioritization purposes, e.g., in connection with the MOE approach, could be seen as a promising opportunity for routine application. However, additional research is needed to assess whether it is possible to define a genotoxicity-derived MOE that can be considered indicative of a low level of concern. To further advance quantitative genotoxicity assessment, priority should be given to the development of new experimental methods to provide a deeper mechanistic understanding and a more comprehensive basis for the analysis of dose–response relationships.
Intrinsic and extrinsic attributes that influence choice of meat and meat products: techniques used in their identification
Authors: Cardona María , Izquierdo Diana , Barat Jose M. , Fernández-Segovia Isabel 
Published: July 2023

Abstract
The aim of this work was to determine the main sensory and non-sensory attributes that influence choice of meat and meat products, and to review the latest trends in sensory analysis techniques and consumer opinion studies. For this purpose, a literature review was carried out. Taste/flavour, texture, appearance, colour and odour were identified as the most relevant intrinsic attributes to influence acceptance. The presence of fat was very important for consumers. Of the most relevant extrinsic attributes, price, origin, production methodology, and certified control measures to preserve food safety and quality, are worth highlighting. Some studies also show interest in healthy natural products with some type of quality certification (credence attributes). Factors directly linked with individuals, such as age, gender or level of education, affect their perception. Women and people with a higher level of education are more aware of the diet-health relation, and older people are also concerned. For sensory analysis and consumer opinion techniques, a wide variety of methodologies is applied depending on studies’ objective. Classic methods, newer quantitative techniques and/or qualitative techniques are often used alone or combined.
Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up
Authors: Detterich Jon , Taylor Michael D. , Slesnick Timothy C. , DiLorenzo Michael , Hlavacek Anthony , Lam Christopher Z. , Sachdeva Shagun , Lang Sean M. , Campbell M. Jay , Gerardin Jennifer , Whitehead Kevin K. , Rathod Rahul H. , Cartoski Mark , Menon Shaji , Trachtenberg Felicia , Gongwer Russell , Newburger Jane , Goldberg Caren , Dorfman Adam L. ,   the Pediatric Heart Network Investigators
Published: July 2023

AbstractThe Single Ventricle Reconstruction (SVR) Trial was a randomized prospective trial designed to determine survival advantage of the modified Blalock-Taussig-Thomas shunt (BTTS) vs the right ventricle to pulmonary artery conduit (RVPAS) for patients with hypoplastic left heart syndrome. The primary aim of the long-term follow-up (SVRIII) was to determine the impact of shunt type on RV function. In this work, we describe the use of CMR in a large cohort follow up from the SVR Trial as a focused study of single ventricle function. The SVRIII protocol included short axis steady-state free precession imaging to assess single ventricle systolic function and flow quantification. There were 313 eligible SVRIII participants and 237 enrolled, ages ranging from 10 to 12.5 years. 177/237 (75%) participants underwent CMR. The most common reasons for not undergoing CMR exam were requirement for anesthesia (n = 14) or ICD/pacemaker (n = 11). A total of 168/177 (94%) CMR studies were diagnostic for RVEF. Median exam time was 54 [IQR 40–74] minutes, cine function exam time 20 [IQR 14–27] minutes, and flow quantification time 18 [IQR 12–25] minutes. There were 69/177 (39%) studies noted to have intra-thoracic artifacts, most common being susceptibility artifact from intra-thoracic metal. Not all artifacts resulted in non-diagnostic exams. These data describe the use and limitations of CMR for the assessment of cardiac function in a prospective trial setting in a grade-school-aged pediatric population with congenital heart disease. Many of the limitations are expected to decrease with the continued advancement of CMR technology.
The relationship of neutrophil-to-lymphocyte ratio with health-related quality of life, depression, and disease activity in SLE: a cross-sectional study
Authors: Papachristodoulou Eleni , Kakoullis Loukas , Christophi Costas , Psarelis Savvas , Hajiroussos Victor , Parperis Konstantinos 
Published: July 2023

AbstractThe neutrophil-to-lymphocyte ratio (NLR) emerged as a potential biomarker in SLE, but its association with several outcomes remains unclear. We aimed to evaluate the relationship between NLR and SLE disease activity, damage, depression, and health-related quality of life. A cross-sectional study was conducted, including 134 patients with SLE who visited the Division of Rheumatology between November 2019 and June 2021. Demographics and clinical data including NLR, Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus disease activity index (SELENA–SLEDAI), Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), physician global assessment (PhGA), patient global assessment (PGA), patient health questionnaire (PHQ)-9, patient self-rated health, and lupus quality of life (LupusQoL) scores, were collected. Patients were stratified into two groups and compared using the NLR cut-off of 2.73, the 90th percentile value of healthy individuals. The analysis included t-test for continuous variables, χ2-test for categorical variables, and logistic regression adjusting for age, sex, BMI, and glucocorticoid use. Among the 134 SLE patients, 47 (35%) had an NLR ≥ 2.73. The NLR ≥ 2.73 group had significantly higher rates of severe depression (PHQ ≥ 15), poor/fair self-rated health, and the presence of damage (SDI ≥ 1). These patients also scored significantly lower in LupusQoL domains (physical health, planning, and body image), and higher in SELENA-SLEDAI, PhGA, and PGA. Logistic regression confirmed that high NLR is associated with severe depression (PHQ ≥ 15) (OR:7.23, 2.03–25.74), poor/fair self-rated health (OR:2.77,1.29–5.96), high SELENA-SLEDAI score(≥ 4) (OR:2.22,1.03–4.78), high PhGA (≥ 2) (OR:3.76, 1.56–9.05), and presence of damage (SDI ≥ 1) (OR:2.67, 1.11–6.43). High NLR in SLE may indicate depression, worse quality of life, active disease, and the presence of damage.
Strength and timing of primary and secondary vortices generated by a rotating plate
Authors: Francescangeli Diego , Mulleners Karen 
Published: July 2023

AbstractAccurate predictions of how vortices grow, evolve, and separate from aerodynamic objects are desirable for various applications ranging from autonomous aerial vehicles to wind turbines. Here, we present an experimental characterisation of the formation process of vortices created by the rotation of a thin rectangular flat plate. The plate is rapidly accelerated from rest up to a constant rotational velocity that was varied to explore the effect of the Reynolds number on the limit strength and the timing of successively generated vortices at the tip of the plate. The total non-dimensional positive circulation released at the tip of the plate during the entire rotation varies solely as a function of the angular position of the plate. Initially, all this circulation accumulates in a primary or starting vortex until this vortex separates after a constant non-dimensional time for all rotational velocities and different plate dimensions tested. An empirical model of the prediction of the limit strength of the primary vortex based on the constant non-dimensional formation is presented. The limit strength of the primary vortex is independent of the Reynolds number. After the primary vortex separates, a series of smaller secondary vortices form at the tip of the plate. These secondary vortices are discretely released at increasing time intervals. The timing of the release of the secondary vortices and their non-dimensional strength depend on the Reynolds number, and an empirical prediction model is presented.
Guideline adherence of tumor board recommendations in lung cancer and transfer into clinical practice
Authors: Walter Julia , Moeller Caroline , Resuli Blerina , Kauffmann-Guerrero Diego , Manapov Farkhad , Dinkel Julien , Neumann Jens , Kovacs Julia , Schneider Christian , Huber Rudolf M. , Tufman Amanda 
Published: July 2023

Abstract
Purpose
Evaluating patients and treatment decisions in a multidisciplinary tumor board has led to better quality of care and longer survival in cancer patients. The aim of this study was to evaluate tumor board recommendations for thoracic oncology patients regarding guideline adherence and transferal of recommendations into clinical practice.

Methods
We evaluated tumor board recommendations of the thoracic oncology tumor board at Ludwig-Maximilians University (LMU) Hospital Munich between 2014 and 2016. We compared patient characteristics between guideline-adherent and non-guideline-adherent recommendations, as well as between transferred and non-transferred recommendations. We used multivariate logistic regression models to evaluate factors associated with guideline adherence.

Results
Over 90% of recommendations by the tumor board were either adherent to the guidelines (75.5%) or over fulfilling guidelines (15.6%). Almost 90% of recommendations were transferred to clinical practice. If a recommendation was not according to the guidelines, the reason was mostly associated with the general condition (age, Charlson comorbidity index, ECOG) of the patient or due to the patients’ request. Surprisingly, sex also had a significant influence on the guideline adherence of recommendations, with females being more likely to get recommendations not according to the guidelines.

Conclusion
In conclusion, the results of this study are promising, as the guideline adherence of recommendations as well as the transferal of recommendations into clinical practice were high. In the future, a special focus should be put on fragile patients as well as female patients.