bluuebunny/crossref_metadata_2025_split huggingface dataset:
İNVAZİV MELANOMLARDA CD271 VE BRAF EKSPRESYONUNUN KLİNİKOPATOLOJİK PARAMETRELERLE VE PROGNOZ İLE İLİŞKİSİNİN İMMÜNOHİSTOKİMYASAL YÖNTEMLE ARAŞTIRILMASI
Authors: KARAHAN Nermin , UĞUZ Afife 
Published: April 2023

Amaç
Amaç: İnvaziv melanomun (İM) en önemli prognostik
faktörleri patolojik evreleme ve metastaz varlığı olarak
bilinmektedir. Patolojik evrelemede tümör boyutu, invazyon
derinliği, ülserasyon, mitotik indeks önem arz
etmektedir. Çalışmamızda BRAF V600E ve CD271’in
immünohistokimyasal (İHK) ekspresyonları ile klinikopatolojik
parametreler ve prognoz ile ilişkisinin incelenmesi
amaçlanmıştır.
Gereç ve Yöntem
Çalışmamızda Süleyman Demirel Üniversitesi Patoloji
Anabilim Dalı’nda Aralık 2010 - Mayıs 2017 tarihleri
arasında tanı almış 47 İM olgusu incelendi. Bu olgulara
BRAF V600E ve CD271 belirleyicileri uygulandı. Bu
belirteçlerin primer ve metastatik İM’lerda ve sağkalım
ile ilişkisi immünohistokimyasal yöntemle araştırıldı.
Ayrıca primer ve metastatik İM’ların ülser, lenfositik infiltrasyon,
pigmentasyon, mitoz, Breslow kalınlığı, metastaz
yapıp yapmaması, yaş, cinsiyet ve sağkalım ile
ilişkisi araştırıldı.
Bulgular
Primer İM’ler ve metastatik İM’ler karşılaştırıldığında
ülserasyon, mitotik indeks açısından, aralarındaki fark
istatistiksel olarak anlamlı bulunurken, Breslow tümör
kalınlığı, lenfositik infiltrasyon, pigmentasyon, CD271
ve BRAF V600E ekspresyonu açısından aralarındaki
fark istatistiksel olarak anlamlı bulunmadı. Sağkalım
ile ilişkilerine bakıldığında Breslow tümör kalınlığı, ülserasyon,
BRAF V600E ekspresyonu şiddeti, BRAF
V600E ekspresyonu olmayanlar ile olanlar arasındaki
ve BRAF V600E ekspresyon şiddeti 3+ olanlar ile
diğerleri arasındaki fark istatistiksel olarak anlamlı
bulundu. Cinsiyet, pigmentasyon, BRAF V600E ekspresyon
yüzdesi, CD271 ekspresyon şiddeti, CD271
ekspresyon yüzdesi ile sağkalım arasında istatistiksel
olarak anlamlı fark bulunmadı. Çalışmamızda Primer
İM’si olan bireylerin yaşları 35-93 arasında değişmekte
olup ortalama 64,12 ± 20,35, metastatik İM grubundaki
bireylerin yaşları 35-89 arasında değişmekte olup ortalama
69 ± 13,42 idi. Yaş yönünden iki grup arasındaki
fark anlamlı bulunmadı.
Sonuç
Çalışmamız sonucunda elde ettiğimiz verilerde BRAF
V600E ekspresyonu prognoz ile ilişkili olduğu gözükmektedir.
BRAF V600E ekspresyonu olmayanlarda
yüksek sağkalım oranları varken ekspresyon şiddeti
yüksek olanlarda sağkalımın azaldığı bulundu. Çalışmamızda
CD271 ekspresyon şiddeti ve yüzdesi açısından
primer ve metastatik İM gruplarında ve sağkalım
arasında istatistiksel olarak anlamlı fark bulmadık.
Effect of technological parameters of the process of pulsed magnetron sputtering on the structure and phase composition on TiN-based coatings
Authors: Soshina Tatyana O. , Mezentseva Daria S. 
Published: April 2023

Subject of research: coatings based on TiN deposited by pulsed magnetron sputtering have been studied.
Purpose of research: is to establish the effect of technological parameters of the process of pulsed magnetron sputtering: the discharge current and the N2 content in the vacuum chamber on the structure and phase composition of coatings based on TiN.
Methods and objects of research: the phase composition and structural characteristics of the TiN-based coating were studied in the course of X-ray diffraction and X-ray phase analysis of coatings. The microstructure of the formed coatings based on TiN was studied using scanning electron microscopy. The object of the study were samples of VK6 hard alloy with TiN coatings.
Main results of research: it has been established that the magnitude of the discharge current has the greatest influence on the formed structure of the TiN coating. An increase in the content of N2 and the discharge current leads to a change in the phase composition and the formation of a single-phase coating based on the (111) c-TiN cubic phase with an increase in the degree of texture of the coating. The optimal values ​​of technological parameters are determined at which a coating based on the c-TiN phase is formed, with a minimum level of internal stresses, the smallest grain size, and a dense, columnar structure.
Study of the quality of electric power in electric networks with semiconductor converters
Authors: Antonov Alexander I. , Rudy Dmitry Yu. , Khatsevsky Konstantin V. 
Published: April 2023

At present, semiconductor converters have found wide application in the electric power industry [6]. One of the most common semiconductor converters is a frequency converter, as it provides a three-phase voltage with adjustable frequency from a three-phase mains voltage. However, it, like other semiconductor converters, is the cause of the appearance of harmonics and, as a result, the non-sinusoidal shape of the voltage curve [1]. Harmonics are the cause of such negative effects in the electrical network as concomitant heating of the windings of motors, transformers, etc., false alarms in distribution networks, asymmetry in industrial networks with three-phase sources when harmonics occur in one phase, the occurrence of noise in communication networks, the influence on adjacent low-current and power cables due to the induced EMF, and also with the appearance of harmonics, there is a need to increase the cross section of neutral wires due to the summation of harmonics multiple of the 3rd in three-phase networks [3]. Therefore, the study of the harmonic components of the voltage is an urgent task.
Subject of research: processes occurring in electrical networks with a frequency converter.
Purpose of research: to identify the presence of harmonic voltage components in electrical networks with a frequency converter.
Object of research: a research stand that simulates the operation of electrical networks with a frequency converter.
Methods of research: in the process of performing research, scientific and technical generalization of literary sources on the initial prerequisites for research, methods of the theoretical foundations of electrical engineering and the theory of electrical networks, the method of analytical research, methods of system analysis were used. Experimental studies were carried out by a complex method using the Resurs-PKE device.
Results of research he study: based on the studies carried out, it was shown that the frequency converter is a source of harmonic voltage components, while harmonics appear only in certain sections of the electrical circuit.
Exemption from criminal liability in connection with compensation for damage (article 76<sup>1</sup> of the Criminal Code)
Authors: Podroykina Inna A. 
Published: April 2023

Subject of research: the norms of Russian criminal legislation regulating exemption from criminal liability in connection with compensation for damages, materials of judicial practice, the work of specialists devoted to the topic of the study.
Purpose of research: to develop scientifically sound proposals for improving the criminal law in terms of determining the types of exemption from criminal liability.
Methods and objects of research: the research is based on the dialectical method of cognition, the formal legal method, as well as methods of analysis, synthesis, induction and deduction. The object of the study is social relations arising in connection with the exemption from criminal liability on the basis of Article 761 of the Criminal Code.
Main results of research: author comes to the conclusion that Article 761 of the Criminal Code is built in violation of the rules of legislative technique, does not have a sign of consistency and each part of it (including the name) requires serious adjustments, which calls into question the very fact of its existence, proposes to exclude it from the criminal law, which will remove a number of disagreements in the theory of criminal law, which will remove a number of disagreements in the theory of criminal law, stabilizes the Criminal Code from rhe point of view of consistency, eliminating the rauncancy of legal regulation.
Investigation of heat transfer in a porous material based on triply periodic surfaces of minimal energy
Authors: Eremin Anton V. , Zinina Sofya A. , Johnson Olatui Oluvapelumi 
Published: April 2023

The subject of research: is a mathematical model of thermal conductivity in a porous flat wall, the structure of which is based on the three times periodic minimal Sean surface I-WP(TPMS).
The purpose of research: to study the course of the heat conduction process in a porous plate at a given porosity. At the same time, the material from which the porous plate is made is PETG plastic.
Methods of research: in this work, the solution was carried out by the finite difference method in the Mathcad software.
Results of the research: temperature distributions were obtained along the spatial coordinate and in time, as well as the distribution of heat flow in time depending on the change in the plate porosity coefficient.
Determination of invariant characteristics for digital image and their calculation in the MatLab system
Authors: Samarina Olga V. , Samarin Valery A. 
Published: April 2023

Subject of research: single-channel digital image, second-order invariants to movements and stretching.
Purpose of research: to determine a new group of invariants of a single-channel digital image with respect to shifts, rotations and stretching.
Methods and objects of research: the object of research is single-channel images. The developed computational algorithms are based on the complex use of analytical and geometric research methods, the theory of invariants and wavelets.
Main results of research: a computational scheme for determining the group of invariant characteristics with respect to such digital image transformations as shifts, rotations and stretching has been developed.
Qualifying signs in the criminal legislationof the Russian Federation: current state
Authors: Kemova Natalia N. 
Published: April 2023

Subject of research: features of the use of qualifying features in criminal law norms.
Purpose of research: to determine universal requirements for qualifying features for their subsequent application in a Special part of the Criminal Code of the Russian Federation.
Methods and objects of research: the methodological basis was the dialectical method of scientific cognition. Also, in the course of the research, private scientific methods of cognition used in the humanities were used. For example, when presenting the material, formulating conclusions and research results, methods of formal logic were used. In determining the criteria for the selection of qualifying features, an inductive, deductive method was used. The content analysis method was used in the study of a Special part of the Criminal Code of the Russian Federation for compliance with the requirements for qualifying features.
Results of research: the content of the requirements for legally significant signs is disclosed, which indicate a significant increase in the degree of public danger of a crime containing signs of the main composition, and therefore are used as qualifying signs in the norms of the Special part of the Criminal Code of the Russian Federation. Proposals are formulated to improve the norms of the current criminal law in terms of the specifics of the use of qualifying features.
THE CORRELATION OF FAMILY SOCIO-ECONOMIC, MAINTENANCE OF DENTAL HEALTH, AND PHYSICAL ENVIRONMENT FACTORS WITH DENTAL AND ORAL HEALTH
Authors: Aspiani Aspiani , Adhani Rosihan , Dwinta Sari Galuh 
Published: April 2023

ABSTRACTBackground: Dental and oral health problems in Indonesia continue to increase. Dental and oral health is part of the overall health of the body. Dental and oral health in adolescents is an essential and integral part of general health seen in the wider community. Junior high school students are teenagers who experience significant development in their lives, both physically, emotionally, socially, and behaviorally. Purpose: To analyze the correlation of family socio-economic, dental health maintenance, and the physical environment factors with dental and oral health conditions in UPT SMP Negeri 1 Cempa students. Material and Methods: This study used an analytic observational method with a cross sectional research design The sample was determined using the sample size correlation formula. The population were students of UPT SMP Negeri 1 Cempa as many as 414 people and the sample used was 40 respondents. Results: Spearman correlation test to determine the correlation between dental health maintenance and oral health obtained the value of Sig. 0.005 means that there is a correlation between the level of dental health maintenance with dental and oral health conditions (p <0.05). There was no significant correlation between the socioeconomic level of the family (Sig. 0.167; p>0.05) and the level of physical environmental conditions (Sig. 0.710; p>0.05) with dental and oral health condition. Conclusion: There is a significant correlation between the level of dental health maintenance and dental and oral health conditions, while the socioeconomic level of the family and the physical environment does not have a correlation with dental and oral health conditions.Keywords: Dental and oral health, Dental health maintenance, Physical environment, Socioeconomic.
ANTIBACTERIAL ACTIVITY OF RAMANIA LEAF EXTRACT (Bouea Macrophylla Griff) AGAINST THE GROWTH Actinomyces spp
Authors: Hayati Nor Laila , Erlita Isyana , Purwaningayu Juli Harnida 
Published: April 2023

ABSTRACTBackground: One of the causes of tooth nerve death or pulp necrosis is microorganisms, namely is Actinomyces spp. Ramania leaf extract (Bouea Macrophylla Griff) contains secondary metabolites, namely triterpenoids, alkaloids, saponins, tannins, flavonoids, steroids, and phenolics which function to inhibit the growth of Actinomyces spp. Purpose: This study aims to analyze the antibacterial activity of ramania leaf extract (Bouea Macrophylla Griff) at concentrations of 6,25%, 12,5%, 25%, 50%, and 100% against the growth Actinomyces spp. Methods: This research is a pure experimental (true experimental), with Posttest Only with Control Group Design. Antibacterial activity test used a paper disc diffusion with seven treatments, namely ramania leaf extract (Bouea Macrophylla Griff) with a concentration of 6,25%, 12,5%, 25%, 50%, and 100%, Chlorhexidine gluconate 2% as a positive control and Aquades as a negative control of Actinomyces spp were repeated 5 times. Measuring the diameter of the clear zone formed on Mueller Hinton Agar (MHA) media using a caliper. Results: Based on the results of the Mann Whitney test, there was 1 pair of groups that did not differ significantly in inhibiting Actinomyces spp bacteria, namely the 25% concentration group with a positive control of 2% Chlorhexidine gluconate, while the other groups had significant differences from each other. Conclusion: There is antibacterial activity in ramania leaf extract (Bouea Macrophylla Griff) against Actinomyces spp. Keywords: Actinomyces spp, Antibacterial Activities, Chlorhexidine gluconate 2%, Ramania Leaf Extract.
COMPREHENSIVE MANAGEMENT OF ORAL FRAILTY IN MULTIPLE SYSTEMIC DISEASES GERIATRIC PATIENT
Authors: Hasanah Novia Tri , Setiadhi Riani 
Published: April 2023

ABSTRACTBackground Oral frailty is an important geriatric syndrome characterized by decreases in oral function that coincides with declines in cognitive and physical function. Objective: The aim of this case report is to describe the comprehensive management of oral frailty in a medically compromised geriatric patient prior to cardiovascular surgery. Case: A 64-year-old male patient complained of pain in swallowing and sore mouth since two days before. He had multiple systemic diseases, including infective endocarditis, acute kidney injury, type II diabetes mellitus, thrombocytopenia, and electrolyte-fluid imbalance. Extra-oral examination showed lymphadenitis, icteric sclera, and dry-exfoliative lips. Intra-oral examination revealed tongue depapillation, frothy saliva, and dry mucosa with poor oral hygiene. The scraped-off white plaque leaving erythematous area was found on the dorsal and ventral tongue, buccal mucosa, and hard palate. Irregular multiple major ulcers, surrounded by erythema, well-demarcated with yellowish concave base, and covered by thick yellowish-green sputum at the soft palate to the uvula. The diagnosis was exfoliative cheilitis, aphthous-like ulcer, acute pseudomembranous candidiasis, and moderate xerostomia. A D-E-N-T-A-L questionnaire was used to evaluate oral frailty, and the cumulative result was seven. Case Management: The patient was treated with 100% petroleum jelly, 0.12% chlorhexidine digluconate mouthwash, and chlorine dioxide-zinc mouthwash three times a day. The oral lesions showed significant improvement after one week of treatment. Conclusion: Appropriate therapy for oral lesions and eliminating the infection could be considered to minimize the long-term effect of oral frailty. The comprehensive management of oral frailty could be beneficial for improving the quality of life. Keywords: Geriatric, Oral frailty, Oral lesion, Systemic disease
THE EFFECT OF IMMERSION IN 50% CONCENTRATION OF KASTURI LEAF EXTRACT (MANGIFERA CASTURI) ON THE DISCOLORATION OF HEAT CURED ACRYLIC RESIN
Authors: Wardhana Agung Satria , Silaen Mikael Manggala , Arifin Rahmad 
Published: April 2023

ABSTRACTBackground: Heat cured acrylic resin and alkaline proxide are the most used material for denture base and denture cleaner. However, the cost of denture cleanser and its discoloration effect after long term use became the major disadvantages of this material. Kasturi leaf extract, in 50% concentration, had been proven to have antibacterial and antifungal effect, such as a denture cleanser properties.. Objective: This study was to determine the discoloration effect of immersing heat cured resin acrylic in to 50% Kasturi leaf extract solution compared to alkaline peroxide and distilled water. Material and Methods: This study used 24 samples of heat cured acrylic following ADA specification no 17, with 15 milimeters diameter and 2 millimeters of thickness. The 50% Kasturi leaf extract treatment group and the control group alkaline peroxide and aquades. Each group consisted of 8 samples which measured the discoloration before and after being immersed for 5 days. The discoloration of the sample was tested using a series of digital analysis tools. The results obtained then converted into the equation of ΔE= [(ΔL)2 + (Δa)2 + (Δb)2]1/2. Results: One Way ANOVA and Post Hoct Bonferroni statistical tests showed that there was a significant difference (p <0.05) between the immersion groups in 50% Kasturi leaf extract (6.75 ± 1.31), alkaline peroxide (3.29 ± 0, 57) and distilled water (2.04 ± 0.60). Conclusion: A 50% solution of Kasturi leaf extract has an effect on the discoloration of heat cured type acrylic resin. Keywords: Discoloration, Heat cured acrylic resin, Kasturi leaves
THE EFFECT OF GLYCERIN APPLICATION ON ROUGHNESS OF NANOHYBRID COMPOSITE RESIN IMMERSED IN ISOTONIC DRINK
Authors: Milenia Laila Rahma , Nelis Surya , Brigitta Natania Renata Purnomo Brigitta Natania , Hardini Nadia 
Published: April 2023

ABSTRACTBackground: Composite resin is the most commonly used restorative material. One type of composite resin based on the filler material is a nanohybrid composite resin which has the advantage of good strength and smooth surface to produce good improvements in terms of durability and aesthetics. The roughness of the resin can be affected by drinks with low pHs, such as isotonic drink. Glycerin can reduce the roughness of the composite resin by acting as a barrier so that an oxygen inhibition layer (OIL) is not formed. Purpose: This study is to determine the effect of glycerin application on the roughness of nanohybrid composite resin immersed in an isotonic drink. Method: A total of 32 samples of nanohybrid composite resin used in this study were made with a diameter of 5 mm and a thickness of 2 mm. The nanohybrid composite resin samples were divided into group I without glycerin application and group II with glycerin application before the light curing process. Both groups were then immersed in an isotonic drink for 18 hours in an incubator. The research continued with roughness testing using a surface roughness tester. Result: There was a significant difference in the roughness of the nanohybrid composite resin immersed in an isotonic drink with and without glycerin application. This is indicated by the p-value < 0.05 in the unpaired bivariate t-test, which means that there is a significant difference in the two sample groups. Conclusion: The application of glycerin can reduce the roughness of the nanohybrid composite resin immersed in isotonic drink. Keywords: Glycerin application, Nanohybrid composite resin, Roughness.
EFFECTIVENESS OF TAMARIND LEAF (Tamarindus indica L.) ETHANOL EXTRACT ANTIBACTERIAL AGAINST Porphyromonas gingivalis
Authors: Wijaya Baiin Yemima Putri , Mandalas Henry Y. , Sugiaman Vinna Kurniawati 
Published: April 2023

ABSTRACTBackground: One of the initial measures to prevent chronic periodontitis is the use of mouthwash. Chlorhexidine is an antibacterial agent that can be used as a mouthwash. Chlorhexidine has side effects so that a new method is needed to prevent periodontitis with fewer side effects, namely by using plants as a medicine, one of the plants containing active compounds with antibacterial effects. The ethanol extract of tamarind leaf is proven to contain active compounds of flavonoids, tannins, alkaloids, and saponins. Purpose: The aim of the study was to analyze the antibacterial effect of ethanol extract of tamarind leaf (Tamarindus indica L.) leaf against Porphyromonas gingivalis bacteria. Material and methods: The research is an experimental laboratory type using the disc diffusion method (Kirby-Bauer), namely the paper disc diffusion method with the test material of ethanol extract of tamarind leaf (Tamarindus indica L.) in various concentrations, namely: 3.125%, 6.25%, 12.5 %, 25%, 50%, and 100%. Results: Based on the results of the research on the antibacterial effect of the ethanolic extract of tamarind leaf with concentrations of 3.125%, 6.25%, and 12.5% with an average diameter of 0.00 mm of inhibition zone. At concentrations of 25%, 50%, and 100%, they fall into the medium criteria group, because they have an average inhibition zone diameter of 5.21 mm, 7.45, and 9.16 mm, so that the concentration of 100% is closest to the average the mean diameter of the positive control group or chlorhexidine. Conclusion: It can be concluded that the ethanol extract of tamarind leaf (Tamarindus indica L.) has an antibacterial effect that can inhibit the growth of Porphyromonas gingivalis bacteria at a concentration of 100% with an average inhibition zone diameter of 9.16 mm. Keywords: Antibacterial, Porphyromonas gingivalis, Tamarind leaf