bluuebunny/crossref_metadata_2025_split huggingface dataset:
ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer
Authors: Tian Lu , Gong Liang , Hao Chu , Feng Yuyang , Yao Surui , Fei Bojian , Wang Xue , Huang Zhaohui 
Published: September 2023

AbstractBackgroundElongin A (ELOA), our previous work revealed, serves as a novel tumor suppressor in colorectal cancer. However, the function and mechanism of ELOA in other cancer types, including gastric cancer (GC), remain to be elucidated.MethodsThe expression of ELOA was measured by quantitative reverse transcription‐polymerase chain reaction and western blot. The effects of ELOA on GC growth and metastasis were assessed through a series of in‐vitro and in‐vivo assays. Furthermore, the potential mechanism of ELOA was revealed by RNA sequencing, dual luciferase reporter assay, chromatin immunoprecipitation, and rescue experiments in GC.ResultsWe uncovered increased expression of ELOA in GC tissues compared with paired normal tissues via bioinformatic analyses and our sample detection. Enhanced ELOA expression in GC tissues was obviously correlated with poor tumor differentiation, lymph node metastasis, advanced tumor stage, and a poor prognosis. A series of functional experiments showed that ELOA promoted the proliferation and metastasis of GC. Mechanistically, we revealed that the decreased levels of miR‐490‐3p caused the upregulation of ELOA in GC. Both RNA‐seq and ChIP assays revealed that ELOA transcriptionally activated retinol‐binding protein 1 (RBP1) by binding to its promotor. Furthermore, specific knockdown of RBP1 reduced the tumor‐promoting ability of ELOA in GC cells.ConclusionsIn summary, our findings demonstrate that ELOA exerts oncogenic properties by activating RBP1 expression, providing the basis for a promising therapeutic target in GC.
Chromatographic and Biological Screening of Chosen Species of Schisandraceae Family: Schisandra chinensis, S. rubriflora, S. sphenanthera, S. henryi and Kadsura japonica
Authors: Sobstyl Ewelina , Szopa Agnieszka , Olszowy‐Tomczyk Małgorzata , Gnat Sebastian , Jafernik Karolina , Choma Irena Maria 
Published: September 2023

AbstractHPLC and TLC profiling was carried out for leaf and fruit extracts of five Schisandraceae species: Schisandra chinensis, S. rubriflora, S. spehenanthera, S. henryi and Kadsura japonica. HPLC measurements confirmed presence of lignans and phenolic compounds in fruits and leaves of all tested species. The most abundant in lignans was S. chinensis fruit extract in which 15 compounds were detected (e. g.: schisandrol A, schisanhenol, γ‐schisandrin, gomisin N). The effect‐directed detection, i. e., TLC‐direct bioautography against Bacillus subtilis, showed exceptionally high activity for S. chinensis and S. rubriflora fruit extracts. On the other hand, TLC‐DB enzyme tests (α‐glucosidase, lipase, tyrosinase and acetylcholinesterase (AChE) inhibition assays) showed that all fruit and leaf extracts have ability to inhibit the above‐mentioned enzymes (except for the K. japonica fruit). The leaf extracts showed much stronger antioxidant activity than the fruit ones, which were assessed and compared using both TLC‐direct bioautography and spectrophotometric measurements based on ABTS, DPPH and FRAP tests.
Unlocking Synergistic Potential: Agomelatine Enhances the Chemotherapeutic Effect of Paclitaxel in Breast Cancer Cell Through MT1 Melatonin Receptors and ER‐alpha Axis
Authors: Dincer Busra , Yildiztekin Gizem , Cinar Irfan 
Published: September 2023

AbstractThis study investigates the potential of agomelatine (AGO), a synthetic melatoninergic drug, in combination with paclitaxel (PTX) for the treatment of breast cancer. The effects of AGO, PTX and melatonin (MTN) on breast cancer cell viability were investigated, focusing on the role of MT1 receptors. Cell viability and gene expression were analyzed in MCF‐7 and MDA‐MB‐231 breast cancer cell experiments. The results show that AGO has cytotoxic effects on breast cancer cells similar to MTN. Combining AGO and MTN with PTX showed synergistic effects in MCF‐7 cells. The study also reveals differences in the molecular mechanisms of breast cancer between estrogen‐positive MCF‐7 cells and estrogen‐negative MDA‐MB‐231 cells. Combination with AGO and PTX affects apoptosis‐associated proteins in both cell types. The findings suggest that AGO, combined with PTX, may be a promising adjuvant therapy for breast cancer and highlight the importance of MTN receptors in its mechanism of action.
Synthesis of Some Benzothiazole Derivatives Based on 3‐Hydroxypyridine‐4‐one and Benzaldehyde and Evaluation of Their β‐Amyloid Aggregation Inhibition Using both Experimental Methods and Molecular Dynamic Simulation
Authors: Asgarshamsi Mohammad Hossein , Dehkordi Mehrdad Mohammadpour , Beigi Hossein Mohammad , Fassihi Afshin , Saghaie Lotfollah 
Published: September 2023

AbstractSome novel inhibitors based on the (benzo[d]thiazol‐2‐yl)‐1‐phenylmethanimine derivatives were designed to reduce the aggregation process in Alzheimer's disease. These structures seem to mimic stilbene‐like scaffold, while the benzothiazole moiety “locks” the thioflavin T binding site. Other inhibitors were designed based on 2‐((benzo[d]thiazol‐2‐ylimino)methyl)‐5‐(benzyloxy)‐1‐methylpyridin‐4(H)‐one derivatives.Benzo[d]thiazol‐2‐amine derivatives were prepared by the reaction of aniline derivatives with ammonium thiocyanate in the presence of bromine/acetic acid. Then, the reaction of amines with benzaldehyde derivatives and 5‐(benzyloxy)‐1‐methyl‐4‐oxo‐1,4‐dihydropyridine‐2‐carbaldehyde gave the desired compounds. The plate reader‐based fibrillation assay was done to evaluate the inhibition of Aβ aggregation. Also, molecular dynamic simulation was carried out to clarify the interaction manner of the designed compounds with Aβ formation.The biological evaluation proved 5a and 7e as the best inhibitor of the Aβ aggregation. compound 5a in the concentration of 50 μM inhibited Aβ fibril formation better than 7e. MD simulation elucidated that the Aβ aggregation inhibitors in different concentrations represented different binding conformations throughout the entire or in one area of Aβ. MD showed the ligands in lower concentrations accumulate in an area of Aβ aggregations and separate one fibril from the aggregated Aβ. On the contrary, in higher concentrations, the ligands tend to be located through the entire Aβ.
Siparuna guianensis Essential Oil Antitumoral Activity on Ehrlich Model and Its Effect on Oxidative Stress
Authors: Viana Barbosa Lucas Gabriel , Silva de Jesus Ellen Nayara , Botelho Jerônimo Lucas , Silva da Costa Jamile , Cunha Silva Renata , Setzer William N. , R. da Silva Joyce Kelly , da Silva Freitas Jofre Jacob , B. Figueiredo Pablo Luis 
Published: September 2023

AbstractThis work aims to evaluate the chemical composition, in vitro antioxidant capacity, and in vivo antitumoral activity of S. guianensis essential oil against Ehrlich's ascitic carcinoma and the effects on oxidative stress. The animals (Mus musculus) received a daily dose of S. guianensis oil orally (100 mg/kg) for 9 days. The main constituents of essential oil were curzerenone (16.4±1.5 %), drimenol (13.7±0.2 %), and spathulenol (12.4±0.8 %). S. guianensis oil showed antioxidant activity, inhibiting 11.1 % of DPPH radicals (95.7 mgTE/g); and 15.5 % of the β‐carotene peroxidation. The group treated with S. guianensis showed a significant reduction in tumor cells (59.76±12.33) compared to the tumor group (96.88±19.15). Essential oil of S. guianensis decreased MDA levels and increased SOD levels in liver tissue. The essential oil of S. guianensis reduced oxidative stress, and showed antitumor and antioxidant activity, being characterized as a new chemical profile in the investigation of pathologies such as cancer.
Generation of Cannabigerolic Acid Derivatives and Their Precursors by Using the Promiscuity of the Aromatic Prenyltransferase NphB
Authors: Spitzer Saskia , Wloka Jasmin , Pietruszka Jörg , Kayser Oliver 
Published: September 2023

AbstractNphB is an aromatic prenyltransferase with high promiscuity for phenolics including flavonoids, isoflavonoids, and plant polyketides. It has been demonstrated that cannabigerolic acid is successfully formed by the reaction catalysed by NphB using geranyl diphosphate and olivetolic acid as substrates. In this study, the substrate specificity of NphB was further determined by using olivetolic acid derivatives as potential substrates for the formation of new synthetic cannabinoids. The derivatives differ in the hydrocarbon chain attached to C6 of the core structure. We performed in silico experiments, including docking of olivetolic acid derivatives, to identify differences in their binding modes. Substrate acceptance was predicted. Based on these results, a library of olivetolic acid derivatives was constructed and synthesized by using different organic synthetic routes. Conversion was monitored in in vitro assays with purified NphB versions. For the substrates leading to a high conversion olivetolic acid‐C8, olivetolic acid‐C2 and 2‐benzyl‐4,6‐dihydroxybenzoic acid, the products were further elucidated and identified as cannbigerolic acid derivatives. Therefore, these substrates show potential to be adapted in cannabinoid biosynthesis.
Endovascular maneuvers for contralateral stent graft limb misplacement in endovascular aortic repair
Authors: Schulte Katrin , Zdoroveac Andrei , Gürke Lorenz , Isaak Andrej 
Published: September 2023

AbstractCannulation and placement of the contralateral stent graft limb during endovascular aortic repair (EVAR) procedure are crucial steps as mispositioning may lead to conversion to open aortic repair. Endovascular bail‐out strategies for stent graft relocation in EVAR are underreported though detailed knowledge may facilitate application and prevent conversion. We present three endovascular bail‐out strategies for repositioning of a mispositioned contralateral stent graft limb. (1) Retraction of the mispositioned component with an inflated reliant balloon and placement of an interposition stent graft after successful cannulation; (2) Push‐maneuver of the mispositioned stent graft into the infrarenal aortic aneurysm with an inflated reliant balloon supported by a large lumen introducer sheath and (3) Parallel placement of a second contralateral stent graft limb displacing the mispositioned one against the atrial wall in cases with adequate vessel diameter. Prevention of stent graft mispositioning by applying recognized tests to ensure correct placement are essential, following the slogan: check twice, deploy once.
Unsaturated bi‐heterometal clusters in metal‐vacancy sites of 2D MoS2 for efficient hydrogen evolution
Authors: Shao Gonglei , Xu Jie , Gao Shasha , Zhang Zhang , Liu Song , Zhang Xu , Zhou Zhen 
Published: September 2023

AbstractThe valence states and coordination structures of doped heterometal atoms in two‐dimensional (2D) nanomaterials lack predictable regulation strategies. Hence, a robust method is proposed to form unsaturated heteroatom clusters via the metal‐vacancy restraint mechanism, which can precisely regulate the bonding and valence state of heterometal atoms doped in 2D molybdenum disulfide. The unsaturated valence state of heterometal Pt and Ru cluster atoms form a spatial coordination structure with Pt–S and Ru–O–S as catalytically active sites. Among them, the strong binding energy of negatively charged suspended S and O sites for H+, as well as the weak adsorption of positively charged unsaturated heterometal atoms for H*, reduces the energy barrier of the hydrogen evolution reaction proved by theoretical calculation. Whereupon, the electrocatalytic hydrogen evolution performance is markedly improved by the ensemble effect of unsaturated heterometal atoms and highlighted with an overpotential of 84 mV and Tafel slope of 68.5 mV dec−1. In brief, this metal vacancy‐induced valence state regulation of heterometal can manipulate the coordination structure and catalytic activity of heterometal atoms doped in the 2D atomic lattice but not limited to 2D nanomaterials.
Metal‐Free Tunable 1,2‐Difunctionalization of Terminal Alkynes: Synthesis of β‐Substituted α,β‐Unsaturated Ketones
Authors: Bhat Muneer‐Ul‐Shafi , Ganie Majid Ahmad , Shah Bhahwal Ali 
Published: September 2023

AbstractA metal‐free tunable 1,2‐difunctionalization of the terminal alkynes showcasing a tandem installation of C−C and C−S bonds has been developed. The key enabling factor for the approach is the use of acetic acid as an acyl source to synthesize β‐substituted α,β‐unsaturated ketones. The reaction at room temperature leads to the regioselective acylation at the terminal carbon of alkynes, whereas at −78 °C, the acylation occurs at the more substituted carbon.
Stimuli‐Responsive Properties on a Bisbenzofuropyrazine Core: Mechanochromism and Concentration‐Controlled Vapochromism
Authors: Nakamura Shotaro , Okubo Kohei , Nishii Yuji , Hirano Koji , Tohnai Norimitsu , Miura Masahiro 
Published: September 2023

AbstractStimulus‐responsive organic materials with luminescence switching properties have attracted considerable attention for their practical applications in sensing, security, and display devices. In this paper, bent‐type bisbenzofuropyrazine derivatives, Bent‐H and Bent‐sBu, with good solubilities were synthesized, and their physical and optical properties were investigated in detail. Bent‐H gave three crystalline polymorphs, and they showed different luminescence properties depending on their crystal packing structures. In addition, Bent‐H exhibited mechanochromic luminescence in spite of its rigid skeleton. Bent‐sBu exhibited unique concentration‐dependent vapochromic luminescence. Ground Bent‐sBu was converted to blue‐emissive, green‐emissive, and green‐emissive high‐viscosity solution states at low, moderate, and high concentrations of CHCl3 vapor, respectively. This finding represents a concentration‐dependent multi‐phase transition with an organic solvent, which is of potent interest for application in sensing systems.
Acid⋅⋅⋅Amide Supramolecular Synthon for Tuning Amino Acid‐Based Hydrogels’ Properties
Authors: Veronese Eleonora , Pigliacelli Claudia , Bergamaschi Greta , Terraneo Giancarlo , Dichiarante Valentina , Metrangolo Pierangelo 
Published: September 2023

AbstractInvited for the cover of this issue is the Laboratory of Supramolecular and Bio‐Nanomaterials, coordinated by Pierangelo Metrangolo, at the Politecnico di Milano, Italy. The image depicts the co‐crystal formed by N‐Fmoc‐pentafluorophenylalanine and benzamide, which is also involved in the formation of their mixed hydrogels. Read the full text of the article at 10.1002/chem.202301743.
Advancing community–academic partnerships to achieve breast health equity: Applying the community‐based participatory model to build capacity for sustained impact
Authors: Glaser Kathryn M. , Dauphin Cassy , Johnson Detric , Harris Narseary , Crabtree‐Ide Christina R. , Bouchard Elizabeth G. 
Published: September 2023

AbstractBackgroundThis formative study leveraged a community–academic partnership to identify barriers to care that are potential sources of breast cancer disparities in Black women. Through this partnership and using a community‐based participatory research approach, the objective was to develop a community task force to inform future interventions aimed at addressing breast cancer disparities and increasing health equity.MethodsThe authors assessed gaps in care related to breast cancer in Buffalo, New York, by collecting and analyzing qualitative data from focus groups and interviews with breast cancer survivors and breast navigation groups assessing barriers and facilitators across the cancer care continuum. Then, community‐based participatory research approaches were used to build a task force to develop an action plan addressing gaps in care.ResultsThe authors conducted a thematic analysis of qualitative findings to understand barriers and facilitators to cancer care. Three main domains of themes emerged, including medical mistrust, fear, and stigma; the importance of patient navigation as a form of social support; and the importance of faith and faith‐based community. Finally, the findings were presented to a newly formed community task force to validate the data collected and set future priorities to address breast cancer disparities and increase breast health equity in the region.ConclusionsThe authors observed that health equity is a critically important issue in cancer care and that developing culturally tailored interventions has the potential to improve care delivery and reduce breast cancer disparities. Learning from and working with community members helps set the future agenda related to health equity.Plain Language Summary

Our overall goal was to assess gaps in breast cancer care in Buffalo, New York, and to use community‐based participatory approaches to build a task force to work toward breast health equity.

Recent and historical data indicate that the Western New York community is facing a continued wide gap in breast cancer mortality trends between Black and White patients.

We collected qualitative data to understand potential sources of inequity related to breast cancer and presented findings to a community task force to set future priorities for addressing breast cancer disparities and increasing breast health equity in our region.
Thermodynamic limit of the first Lee‐Yang zero
Authors: Jiang Jianping , Newman Charles M. 
Published: September 2023

AbstractWe complete the verification of the 1952 Yang and Lee proposal that thermodynamic singularities are exactly the limits in of finite‐volume singularities in . For the Ising model defined on a finite at inverse temperature and external field h, let be the modulus of the first zero (that closest to the origin) of its partition function (in the variable h). We prove that decreases to as Λ increases to where is the radius of the largest disk centered at the origin in which the free energy in the thermodynamic limit is analytic. We also note that is strictly positive if and only if β is strictly less than the critical inverse temperature.
Comparison of Pharmacokinetics and Bioavailability of Fixed‐Dose Combination Tablet and Monotherapy Combination of Allisartan Isoproxil and Indapamide Sustained‐Release in Healthy Chinese Volunteers
Authors: Fan Ni , Gongmin Zhou , Wenming Cheng , Jiao Yang , Ruijie Zhang , Yan Chen , Xiangming Tong , Yi Wu 
Published: September 2023

AbstractThis study aimed to compare the pharmacokinetics and bioavailability of 2 formulations: a fixed‐dose combination tablet containing allisartan isoproxil (AI) and indapamide sustained‐release (SR), and a monotherapy combination of AI and indapamide SR, in healthy Chinese subjects. A monocentric, open‐label, single‐dose, randomized, 2‐way crossover study design was implemented. A total of 38 healthy male and female volunteers were equally divided into 2 treatment sequences. The analysis of plasma concentrations was conducted using a nonstereospecific liquid chromatography/tandem mass spectrometric method. The primary pharmacokinetic parameters were calculated using a noncompartmental model. Safety assessments were performed throughout the study. For the fixed‐dose combination and monotherapy combination, the mean values of EXP3174 (metabolite of AI) Cmax, AUC0‒t, and AUC0‐∞ were 987 and 999 ng/mL, 8059 and 7749 ng/mL h, and 8332 and 8007 ng/mL h, respectively. The corresponding values for indapamide were 27 and 32 ng/mL, 1002 and 1105 ng/mL h, and 1080 and 1172 ng/mL h. No serious adverse events were reported during the study. The combination tablet containing 240 mg of AI and 1.5 mg of indapamide SR met the bioequivalence standards. Additionally, both formulations were tolerated and had good safety profiles in the research.
Group schema therapy for cluster‐C personality disorders: A multicentre open pilot study
Authors: Wibbelink Carlijn J. M. , Venhuizen Anne‐Sophie S. M. , Grasman Raoul P. P. P. , Bachrach Nathan , van den Hengel Charlotte , Hudepohl Sandy , Kunst Liselotte , de Lange Hinde , Louter Mark A. , Matthijssen Suzy J. M. A. , Schaling Arita , Walhout Simone , Wichers Karen (Renske) , Arntz Arnoud 
Published: September 2023

AbstractBackgroundGroup schema therapy (GST) is increasingly popular as a treatment for personality disorders (PDs), including Cluster‐C PDs. Individual ST has proven to be effective for Cluster‐C PD patients, while the evidence for GST is limited. This study aimed to investigate the effectiveness of GST for Cluster‐C PD. Moreover, differences between the specific Cluster‐C PDs (avoidant PD, dependent PD and obsessive‐compulsive PD) were explored.MethodsA multicentre open trial was conducted, including 137 patients with a Cluster‐C PD (avoidant PD: n = 107, dependent PD: n = 11 and obsessive‐compulsive PD: n = 19). Patients received 30 weekly GST sessions with a maximum of 180 min of individual ST and five optional monthly booster sessions. Outcome measures including Cluster‐C PD severity, general psychopathological symptoms, quality of life, functional impairment, happiness, PD‐related beliefs, self‐esteem, self‐ideal discrepancy, schemas and schema modes were assessed at baseline until 2‐year follow‐up with semi‐structured interviews and self‐report measures. Change over time and differences between the specific Cluster‐C PDs were analysed with mixed regression analyses.ResultsThe outcome measures showed significant improvements for all Cluster‐C PDs, with medium to large effect sizes after 2 years. A treatment dropout rate of 11.7% was found. There were some indications for differences between the Cluster‐C PDs in severity at baseline, change trajectories and effectiveness of GST.ConclusionsThis study demonstrated that GST is a promising treatment for Cluster‐C PDs. The following step is a randomized controlled trial to further document the (cost‐)effectiveness of GST.
The emotionally exhausted treating the mentally unwell? A systematic review of burnout and stress interventions for psychologists
Authors: Bell Caitlin , Roberts Genevieve L. R. , Millear Prudence M. , Allen Andrew , Wood Andrew P. , Kannis‐Dymand Lee , Jona Celine M. , Mason Jonathan 
Published: September 2023

AbstractHealthcare providers are at high risk of occupational burnout, which has negative implications on the individual, their profession, the organisation and their patients. Psychologists are particularly susceptible to the repercussions of burnout due to the emotionally draining nature and content of their work. However, research has failed to outline and evaluate effective interventions for burnout within the profession. This study aimed to investigate the treatment effectiveness of burnout through a systematic literature review. Systematic searches of four databases using Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) guidelines were conducted. A total of 4832 articles were identified, and 15 were included in the final analysis. The search was limited to scholarly and peer‐reviewed journals published in the English language, which measured and utilised a form of intervention for the treatment of burnout or stress and included participants within the psychology profession. Interventions identified included mindfulness, training courses, self‐care and other therapy‐based forms of interventions. Approximately 60% of study participants reported moderate to high levels of stress. Interventions were largely variable in modality, frequency and duration of sessions and follow‐up period. Of the 15 studies included within the review, only four measured burnout as an outcome variable, while the others measured stress. Findings of this systematic review indicate that mindfulness‐based interventions may be a starting point for reducing stress; however, the most effective intervention for psychologists who have reached burnout is largely unclear. It is recommended that future studies focus on the identification and measurement of burnout, are more rigorously designed and reported and consider peer‐based online support approaches.