bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of Invasive Pneumococcal Diseases Cases Among U.S. Children With Hematologic Malignancies Before and After Introduction of Thirteen-valent Pneumococcal Conjugate Vaccine, 2005–2019
Authors: Hamilton Katie , Luvsansharav Ulzii-Orshikh , Xing Wei , Gierke Ryan , King Jessica , Farley Monica M. , Schaffner William , Thomas Ann , Chai Shua J. , Harrison Lee H. , Holtzman Corinne , McGuire Suzanne M. , Petit Susan , Barnes Meghan , Angeles Kathy M. , Chochua Sopio , McGee Lesley , Kobayashi Miwako 
Published: January 2025

Background:
Children with hematologic malignancies (HMs) are at increased risk of invasive pneumococcal disease (IPD). Data on long-term IPD trends in U.S. children with HM after 13-valent pneumococcal conjugate vaccine (PCV13) introduction are limited. We assessed IPD trends in children with HM before and after PCV13 introduction and the proportion of IPD cases caused by serotypes contained in new pneumococcal conjugate vaccines (PCV15 and PCV20, introduced after 2019).

Methods:
During 2005–2019, IPD cases among children aged <18 years were identified through the Active Bacterial Core surveillance. We characterized IPD cases by underlying conditions (HM, other IPD risk factors, no IPD risk factors) and time periods [pre-PCV13 (2005–2009), early-PCV13 (2010–2014) and late-PCV13 (2015–2019)]. We estimated incidence rate ratios (IRRs) in children aged <5 years with and without HM and during 2010–2019.

Results:
We identified 5912 cases of IPD in children aged <18 years; 215 (3.6%) were among children with HM. The proportion of IPD cases with PCV13 serotypes decreased over time in all risk groups; however, IRRs among children with vs. without HM were 215.8 [95% confidence interval (CI): 146.1–292.4] and 240.9 (95 CI: 152.3–341.1) in early and late-PCV13 periods, respectively. In late-PCV13 period, PCV15/non-PCV13 serotypes and PCV20/non-PCV15 serotypes caused 19.4% and 4.8% of IPD cases among children with HM.

Conclusions:
The proportion of PCV13-type IPD decreased in all children after PCV13 introduction. However, children with HM remain at an increased risk of IPD. Continued monitoring of the impact of PCV15 and PCV20 use among children with HM is needed.
Real world experience in treatment outcome and genomic insights for metastatic prostate neuroendocrine carcinoma
Authors: Lai Jiun-I , Peng Yu-Ching , Chang Peter Mu-Hsin , Chang Yen-Hwa , Chung Hsiao-Jen , Huang Yi-Hsiu , Lin Tzu-Ping , Huang William J , Wei Tzu-Chun , Huang Tzu-Hao , Yen Chueh-Chuan 
Published: January 2025

Background:
Neuroendocrine prostate cancer (NEPC) (de novo or treatment related [t-NEPC]) is a rare and deadly variant of prostate cancer. While de novo NEPC is rare, t-NEPC occurs more frequently in patients with castration-refractory prostate cancer.
Owing to the rarity of NEPC, no standard treatment has been established, and the outcomes are generally unsatisfactory.

Methods:
This study retrospectively reviewed NEPC cases at Taipei Veterans General Hospital between 2018 and 2023. Clinical outcomes, treatment modalities, and related genomic profiles were recorded. We also performed a literature review of case series reporting the outcomes of chemotherapeutic regimens for NEPC.

Results:
From 2158 cases of prostate cancer cases diagnosed during the study period, only seven had pathologically proven NEPC (0.3%), and the median overall survival was 364 d. Three patients who underwent multi-gene panel sequencing had mutations in RB1, and DLL3 immunohistochemical staining showed a positivity rate of 50%. We performed a literature review on chemotherapy outcomes in patients with NEPC. In six studies with 104 patients, etoposide + platinum treatment was most commonly used. The progression free survival (PFS) and overall survival ranged from 3.4 to 9.3 and 8.4 to 22.4 months, respectively. The response rates ranged from 44% to 69.2%. These studies were consistent with a dismal overall survival rate, despite a high response rate to the initial chemotherapy regimen.

Conclusion:
Our study reported poor outcomes with chemotherapy, with a high frequency of RB loss and DLL3 positivity. Further clinical developments targeting DLL3 are warranted.
Two novel SNPs Rs1736952 and Rs17354984 are highly associated with uveitis in ankylosing spondylitis
Authors: Huang Ssu-Cheng , Hwang De-Kuang , Fang Wei-Chieh , Hsieh Ai-Ru , Shih Mei-Lin , Zhuang Zi-Qing , Gao Chong-En , Lin Tai-Chi , Chen Shih-Jen , Hsu Chih-Chien 
Published: January 2025

Background:
Noninfectious anterior uveitis shares genetic factors, including HLA-B27, with ankylosing spondylitis (AS). The aim of this study was to identify significant single nucleotide polymorphisms (SNPs) associated with noninfectious anterior uveitis in AS patients, which could help predict the risk of developing this condition and provide deeper insights into its genetic underpinnings.

Methods:
A genome-wide association study (GWAS) was conducted utilizing the genomic data of 468 AS patients, including 90 with noninfectious anterior uveitis and 378 without it, from the Taiwan Precision Medicine Initiative. This study identified associated genes via SnpXplorer and developed a polygenic risk score (PRS) model to identify AS patients with increased risk of noninfectious anterior uveitis. Biological pathways were analyzed via Enrichr-KG and various databases.

Results:
GWAS revealed two novel SNPs, rs1736952 and rs17354984, with p values < 5x10-8, and seventy-four SNPs with p values < 1x10-4. The associated genes were involved mainly in antigen presentation, interferon signaling, immune regulation pathways, ciliary movement, and neurodegeneration. An optimal PRS model was built using nineteen SNPs with an area under the curve of 0.907.

Conclusion:
Our results revealed that two novel and significant SNP loci, rs1736952 and rs17354984, are strongly associated with noninfectious anterior uveitis in patients with ankylosing spondylitis. However, their roles in uveitis and other immune disorders warrant further investigation.
Partial Nephrectomy Versus Tumor Ablation for T1 Renal Cell Carcinoma: Equally Effective?
Authors: Zeelenberg A. M. , KleinJan G. H. , van der Meer R. W. , Bevers R. F. M. 
Published: January 2025

Purpose:
Partial nephrectomy (PN) is the standard of care for T1 renal cell carcinoma (RCC). Percutaneous tumor ablation (TA) is advised only as an alternative. Research into the oncological outcomes after TA has been conflicting and lacking in quality. Our intent was to compare oncological outcomes after TA with PN.

Materials and Methods:
A single-center, retrospective data analysis was performed. Patients who received a PN or TA between 2006 and 2019 were included. Treatment choice was based on tumor characteristics, comorbidity, and patients' preference. Only patients with histologically proven RCC, who would have been eligible for both treatments, were included. Outcomes were analyzed using the Kaplan-Meier survival curve.

Results:
One hundred twenty patients after PN and 48 patients after TA were included. Age in the TA group was significantly higher (58 vs 70 years, P < .001). Residual tumor and local recurrence was similar for PN vs TA (residual tumor 0% vs 2.1%, P = .113 and local recurrence 1.7% vs 6.3%; P = .114). PN resulted in longer local recurrence–free survival (P = .017). Complications were similar with a total of 20% (PN) vs 18.8% (TA) (P = .854). Limitations include retrospective design and a smaller TA group.

Conclusions:
PN did not result in fewer local recurrences; however, local recurrence–free survival is longer. TA is a safe treatment of localized RCC, with an efficacy close to that of PN. Patients who are eligible for both treatments should be counseled to reach a well-informed decision. More prospective research is needed.
Self-Efficacy Assessment of Women With Stress Urinary Incontinence Undergoing Pelvic Floor Muscle Training: A Secondary Analysis of a Randomized Clinical Trial
Authors: de Figueiredo Vilena B. , Moreira Mayle A. , Sousa Ana Jéssica dos S. , do Nascimento Simony L. , Driusso Patricia 
Published: January 2025

Purpose:
Pelvic floor muscle training (PFMT) is the first-line treatment for stress urinary incontinence (SUI) and mixed urinary incontinence (MUI) in women. As low adherence to PFMT affects the clinical evolution of patients, understanding the self-efficacy (performance expectation and results expectation) of women undergoing PFMT can contribute to developing strategies for improving treatment adherence. This study aimed to analyze the self-efficacy of women with SUI before and 6 months after completion of PFMT.

Methods:
This secondary analysis of a randomized clinical trial was conducted in 2 regions in Brazil. The participants performed a PFMT protocol supervised by a physical therapist and answered the Self-Efficacy Scale for Practicing Pelvic Floor Exercises (SESPPFE) at baseline, after 12 weeks of supervised training, and after 3 and 6 months of unsupervised training.

Results:
Altogether, 90 women with a mean age of 53 (±12.5) years were enrolled. Scores for performance expectation and total SESPPFE decreased after the unsupervised training compared to after 12 weeks of supervised training. Performance expectation scores also decreased after 6 months of supervised PFMT.

Discussion:
Women with SUI and MUI had high self-efficacy scores (performance expectation and results expectation) for supervised PFMT at treatment initiation. These high self-efficacy levels were maintained even after 12 weeks of supervision. However, scores for both total SESPPFE and performance expectation declined after 3 months of unsupervised training and further decreased after 6 months, indicating a drop in participants’ self-efficacy during the unsupervised PFMT period.
Prevalence of Pelvic Health Conditions and Associated Factors in a Male Population
Authors: Woodard Chad , Krakowsky Mackenna , Widawsky Jolie , Wolkenfeld Tzvi 
Published: January 2025

Purpose:
Much of the published pelvic floor literature concerns female pelvic health. A gap exists for understanding male pelvic health conditions, prevalence, and associated factors. There is little published research on a younger population of men experiencing pelvic health conditions, unrelated to prostatectomy. This study was to determine the prevalence of pelvic health conditions within a male sample, and to identify associated factors with these conditions such as age, income, smoking history, and mental health.

Methods:
This study was a cross-sectional design utilizing survey responses. Data was collected using an anonymous self-reported survey. Data collection took place over a span of 18 months and concluded in November 2022. Participants inclusion criteria was biologically born males 18 years and older.

Results:
479 participants met the inclusion criteria. Significant results included a high percentage reporting multiple pelvic floor conditions (P < .001), and significant prevalence of urinary complaints among 25- to 34-year-old males with 32% reporting dysfunction (P < .001). The rate of urinary complaint was reported at a high percentage for those with a higher household income, while higher reports of bowel dysfunction were reported in those participants with a history of smoking (P < .05). Mental health conditions also strongly associated to reports of pelvic health conditions.

Discussion:
The results of this study offer insights into the prevalence of male pelvic health, associated factors, and that men are experiencing pathology at younger ages. The findings will advance the field of pelvic floor physical therapy specific to a male population.
Unmasking the Toll of COVID-19 on Physical and Mental Health of Caregivers of Young Children in the United States
Authors: Havens Kathryn L. , Starnes Catherine P. , Bagwell Jennifer J. 
Published: January 2025

Purpose:
The COVID-19 pandemic has had a profound impact on perinatal health. While much research has focused on this topic, few studies have compared lived experiences during the pandemic to a truly pre-pandemic time point, which has limited our understanding of the pandemic’s influence. In this study, we asked caregivers about their physical health, including symptoms of back pain, urinary incontinence, and pelvic organ prolapse, all common dysfunctions postpartum, and their mental health. We hypothesized that participants would identify similar physical but worsened mental health during the pandemic.

Methods:
We conducted an anonymous, voluntary survey in spring 2019 (pre-pandemic group) and readministered similar questions in fall 2021 to understand the pandemic’s impact (pandemic group).

Results:
A total of 3483 responded to the first survey and 318 during the pandemic. Compared to pre-pandemic, participants reported worsened scores for back pain, urinary incontinence, and pelvic organ prolapse during the pandemic. They also reported worsened stress, anxiety, and depression. For the pandemic group, the greater perceived impact of COVID on daily life was related to greater (worse) scores for urinary incontinence, and all mental health measures.

Discussion:
This study adds to the body of literature showing the effects of COVID on maternal mental health and further shows that physical health, particularly areas of common postpartum dysfunction, has been detrimentally affected by the pandemic as well. This study highlights the need for health care providers and policymakers to prioritize flexible perinatal health support during times of crisis and in the long term.
Inadequate awareness and attention to non-HDL cholesterol: undertreatment of high-risk patients in cardiology practice in Turkey
Authors: Mert Gurbet Özge , Mert Kadir Uğur , Başaran Özcan , Doğan Volkan , Rencüzoğullari İbrahim , Özlek Bülent , Çinier Göksel , Özlek Eda , Biteker Murat , Kayikçioğlu Meral ,   on behalf of EPHESUS Investigators
Published: January 2025

Background
The relationship between low-density lipoprotein cholesterol (LDL-C) and atherosclerotic cardiovascular disease (ASCVD) is well-established. Recently, non-high-density lipoprotein cholesterol (non-HDL-C) has been validated as a superior predictor of ASCVD, especially in individuals with mild to moderate hypertriglyceridemia. The EPHESUS study evaluated real-life hypercholesterolemia management and awareness of non-HDL-C in cardiology outpatient practices.

Methods
Data from 1868 patients with ASCVD or high-risk primary prevention were analyzed to assess cholesterol goal attainment, statin adherence, and physician perceptions. This analysis focused on awareness of non-HDL-C as an ASCVD predictor, adherence to lipid-lowering therapy, and clinicians’ perceptions. Associations between patient demographics, clinical characteristics, and statin adherence were examined.

Results
Among patients, 20.2% achieved non-HDL-C and 16.5% achieved LDL-C goals. In primary prevention, 18.1% reached non-HDL-C and 10.6% reached LDL-C goals, while in secondary prevention, 20.8% and 18.0% met these goals. High-intensity statin therapy was observed in 21.2% of patients, with 30.3% and 24.3% achieving non-HDL-C and LDL-C targets, respectively. Statin use was lower in women than men (54.0% vs 66.9%, P < 0.001). Women less frequently achieved non-HDL-C and LDL-C goals in both prevention groups.

Conclusions
Non-HDL-C goal attainment remains suboptimal in both primary and secondary prevention of hypercholesterolemia, particularly in women who had lower statin use and goal achievement. These findings highlight the need for improved awareness, education, and treatment strategies to reduce residual cardiovascular risk and improve outcomes.
Factors Associated With Fear of Cancer Recurrence in Colorectal Cancer Patients: A Meta-analysis in Health Ecological Perspective
Authors: Sheng Yanlei , Li Qingyi , Shen Fan , Hu Luhong , Li Jie , Wang Qianyun , He Li 
Published: January 2025

Background
Fear of cancer recurrence is a major source of stress and unmet need for colorectal cancer patients.

Objective
This review aimed to identify factors influencing fear of cancer recurrence in colorectal cancer patients.

Methods
Multiple electronic databases were systematically searched for studies from inception to January 2024 using concepts “colorectal neoplasm,” “fear,” and “recurrence.” Two authors independently screened, assessed the quality of eligible studies, and extracted relevant data. The synthesis of effect sizes was conducted using R software version 4.3.1.

Results
A total of 20 studies were included, of which 11 were of moderate quality and 9 were of high quality. The studies reported on 22 potential influencing factors across 5 levels of the health ecological model, including innate personal traits, psychobehavioral factors, interpersonal network factors, living and working conditions, and policy environment factors. After synthesizing the data, it was found that all 22 factors were significantly associated with fear of cancer recurrence in colorectal cancer patients. Of these, 9 factors showed a moderate correlation with fear of cancer recurrence (0.3 < r ≤ 0.6), whereas 13 factors showed a lower level of correlation (r ≤ 0.3).

Conclusions
The factors associated with the fear of cancer recurrence in colorectal cancer patients are complex and partially modifiable.

Implications for Practice
This study suggests that healthcare providers can use a health ecological perspective to provide interventions targeting these factors for colorectal cancer patients to effectively alleviate their fear of cancer recurrence and improve their quality of life.
Resilience in Newly Hired Nursing Faculty
Authors: Sandiford Dione , Birnbaum Shira 
Published: January 2025

Background:
Resilience plays a role in workforce retention and has been linked to job satisfaction, quality of life, and organizational commitment in nursing faculty. Research on the nature of faculty resilience, however, remains sparse.

Purpose:
The purpose of this study was to contribute to the understanding of nurse faculty resilience by describing examples of specific ways that a group of newly hired nursing faculty enacted resilience during their first few years on the job.

Methods:
Transcripts from one-on-one interviews with 23 faculty in 7 U.S. states were analyzed in a secondary analysis, which generated exemplars of resilience in practice.

Results:
Faculty expressed resilience through specific measures that included positive self-talk, reframing of adverse events, drawing analogies to familiar experience, asserting self-worth by helping others, and extensive social networking.

Conclusion:
These actions enabled faculty to find meaning and support in difficult circumstances.
Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery?
Authors: Cho Elizabeth , House Hanna , Marten Andrew , Feffer Marina , Agel Julie , Scolaro John , Marmor Meir , Levack Ashley E. ,   OTA Classification & Outcomes Committee
Published: January 2025

Abstract

Objectives:
The purpose of this investigation was to evaluate the utility of the Centers for Disease Control (CDC) Surgical Wound Classification (SWC) in predicting surgical site infection (SSI) after orthopaedic trauma procedures.

Design:
Retrospective cohort study.

Setting:
Level I academic trauma center.

Patients/Participants:
Adult patients with operatively treated fractures of the leg, ankle, and hindfoot between 2007 and 2022.

Intervention:
N/A.

Main Outcome Measurements:
Presence of SSI was determined by selective chart review of patients who met the screening variables for repeated procedures, open fracture, abscess or wound debridement, intraoperative cultures, or infectious disease consultation (n = 551).

Results:
Two thousand seven hundred ninety-one fractures among 2780 patients (n = 11 with bilateral fractures) were included. The overall infection rate was 2.3% (n = 63), and SWC was significantly associated with infection rates (I/clean: 1.0%, II/clean-contaminated: 3.4%, III/contaminated: 6.2%, IV/dirty: 9.8%, P < 0.001). When compared with Class I, Classes II through IV had increased odds of infection (odds ratio [OR] II: 3.5, P = 0.012; OR III: 6.8, P < 0.001; OR IV: 11.0, P < 0.001). Subgroup analysis of Classes II and III demonstrated no difference in odds of infection. When stratifying open versus closed fractures, there was no statistical association between CDC SWC and odds of infection.

Conclusions:
The CDC SWC has notable limitations for patients with orthopaedic trauma, with ambiguity of classification assignment and decreased discriminatory ability within the central classes. While overall SWC is associated with infection, the relationship seems to be confounded by the effect of open versus closed fractures. Alternative classification systems may have improved utility for stratifying risk in orthopaedic patients.

Level of Evidence:
III.
Situational Analysis of the Medication Practices in Brazilian Hospitals: A Multicenter Study
Authors: Guimarães Pedro Henrique﻿ , Rosa Mário Borges﻿ , Reis Adriano Max Moreira﻿ , Detoni Kirla Barbosa﻿ , Rodrigues Gabriela de Paula Guimarães , Nascimento Mariana Martins Gonzaga 
Published: January 2025

Objective:
To carry out a situational analysis of the medication practices in Brazilian hospitals through the Medication Safety Self-Assessment for Hospitals and the factors associated with better performance in the evaluation.

Methods:
This is a multicenter cross-sectional study in which the results of the application of the Medication Safety Self-Assessment for Hospitals, between 2015 and 2020, in 30 Brazilian hospitals were described. In addition, whether the institutional profile was associated with higher self-assessment scores (better performance in the evaluation) was also evaluated.

Results:
An average proportion of points obtained of 36.7±10.9% was identified (minimum=11.5%; maximum=59.7%), from a score ranging from 0 to 1826 points. The need to improve the use of devices for the preparation and administration of drug solutions, professional development, and patient education was highlighted. A positive association was identified between higher scores and the large or very large size of the hospitals (P=0.026) and having accreditation certification (P=0.007).

Conclusions:
The study made it possible to identify the main weak points and opportunities for improvement of the medication system in the evaluated hospitals, bringing important reflection to national institutions.
Childhood, adolescents and young adults cancer survivors: health promotion and wellbeing interventions
Authors: Dionisi-Vici Margherita , Giacoppo Ilenia , Zucchetti Giulia , Fagioli Franca , Felicetti Francesco 
Published: January 2025

Purpose of review
Childhood, adolescent and young adult cancer (CAYAC) can impact on survivors’ physical but also psycho-social sphere, especially on educational and occupational outcomes. The purpose of this review is to identify the interventions that have been implemented to address these critical developmental stages, which are essential for survivors’ wellbeing.

Recent findings
A cancer diagnosis can delay or interrupt educational achievements, work placement and financial independence. Risk factors for unemployment are: female gender, younger age at diagnosis, survivors of central nervous system cancer, neuro-cognitive dysfunction, chronic health conditions. Social support systems and resilience, instead, can positively impact on occupational functioning of survivors.

Summary
Vocational counselling service, career support, as well as employment programs guided by guidance counsellor, are tailored intervention measures that can enhance psycho-social wellbeing and fill the unique needs of CAYACS survivors’ population. Rehabilitation and long-term follow-up paths should include a multidisciplinary team.