bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of urinary potassium to creatinine ratio to predict diuretic response in patients with acute heart failure and preserved ejection fraction
Authors: Llàcer Pau , Núñez Julio , Croset François , García Marina , Fabregate Martín , Ruiz Raúl , López Genoveva , Fernández Cristina , Del Hoyo Beatriz , Campos Jorge , Gomis Antonio , Manzano Luis 
Published: June 2023

AbstractBackgroundPatients with acute heart failure (AHF) require intensification in the diuretic strategy. However, the optimal diuretic strategy remains unclear. In this work, we aimed to evaluate the role of urinary potassium to creatinine ratio (K/Cr) to predict diuretic and natriuretic response to thiazide or mineralocorticoid receptor antagonists (MRAs) in a cohort of patients with AHF and preserved ejection fraction (AHF‐pEF).HypothesisPatients with a high urinary K/Cr ratio will have a better diuretic and natriuretic response with spironolactone versus chlorthalidone.MethodsThis is a study of 44 patients with AHF‐pEF with suboptimal loop diuretic response. The primary endpoint was the baseline K/Cr associated with natriuretic and diuretic effect of chlorthalidone versus spironolactone at 24 and 72 h. Mixed linear regression models were used to analyze the endpoints. Estimates were reported as least squares mean with their respective 95% confidence interval (CIs).ResultsThe median age of the study population was 85 years (82.5−88.5), and 30 (68.2%) were women. The inferential multivariate analysis suggested a greater natriuretic and diuretic effect of chlorthalidone across K/Cr levels. In the upper category, chlorthalidone translated into a statistically increase in natriuresis at 24 and 72 h. Chlorthalidone versus spironolactone showed ∆uNa of 25.7 mmol/L at 24 h (95% CI = −3.7 to 55.4, p = .098) and ∆uNa of 24.8 mmol/L at 72 h (95% CI = −4 to 53.6, p = .0106). The omnibus p value is .027. Multivariate analyses revealed a significant increase in 72 h cumulative diuresis irrespective of K/Cr status in those on chlorthalidone.ConclusionsIn patients with AHF‐pEF and suboptimal diuretic response, diuresis and natriuresis are higher with the administration of chlorthalidone over spironolactone. These data don't support the hypothesis that the K/Cr ratio can help guide the choice of thiazide diuretic versus MRA in AHF‐pEF patients on loop diuretic.
Aggregation‐Induced Enhanced Emission of a Dimethylacridan Substituted Pyrimidine Derivative
Authors: Massue Julien , Diarra Lacina , Georgoulis Ioannis , Fihey Arnaud , Robin‐le Guen Françoise , Ulrich Gilles , Fakis Mihalis , Achelle Sylvain 
Published: June 2023

AbstractA pyrimidine chromophore bearing an acridan fragment was synthesized and its photophysical properties were studied. In solution, this compound is characterized by an important positive emission solvatochromism with a shift of 5800 cm−1 between nonpolar heptane and dichloromethane (DCM) associated with large Stokes shifts (up to 9100 cm−1 in DCM). Mono‐exponential fluorescence decays are observed in heptane whereas more complicated bi‐ or three‐exponential decays are observed in more polar solvents due to an interplay between locally excited and charge transfer excited state. Additionally, an aggregation‐induced enhanced emission process was demonstrated in THF/water mixtures. At low temperature (77 K), in a polymethylmethacrylate (PMMA) thin film, the presence of an accessible triplet state (T1) was demonstrated, which was not observed in solution. Finally, we show that it is possible to protonate the chromophore in thin film leading to panchromatic dual emission
Merging Organocatalysis and Photocatalysis: A New Momentum in Covalent Radical Catalysis
Authors: Archer Gaétan , Song Kunlong , Médebielle Maurice , Merad Jérémy 
Published: June 2023

AbstractThe use of free radicals as organocatalysts constitutes a powerful strategy to activate and functionalize unsaturated carbon chains. Indeed, the unique affinity of open‐shell species for alkenes and alkynes can be rerouted to achieve the catalytic covalent activation of the substrate and control a subsequent radical cascade. However, the field of covalent radical catalysis has remained challenging for decades due to important issues in terms of catalyst handling, reaction design and viability. Recently, these pitfalls have been addressed one by one by the use of photocatalysis to control the generation and the reactivity of radical catalysts. This Concept article aims to highlight recent achievements in the field of photocatalyzed covalent radical catalysis and the perspectives offered by such catalytic combinations. The reaction mechanisms and the interconnection between the catalytic cycles are reviewed with the hope of demonstrating the synthetic potential of this approach and foster a rapid growth of this nascent topic.
Carotenoid biosynthesis in durian pulp
Authors: Ketsa Saichol , Warrington Ian J. 
Published: June 2023

AbstractDurian (Durio zibethinus Murray) is an important economic crop in Southeast Asian countries. Analysis of the composition of durian pulp indicates that it has high nutraceutical value that is related to the presence of bioactive antioxidant compounds, with carotenoids being one of the important constituents. The major carotenoids are β‐ and α‐carotene, with the minor carotenoids being lutein and zeaxanthin. Carotenoid biosynthesis in durian pulp involves the coordinated expression of many genes with at least nine genes encoding enzymes having been identified. Carotenoid accumulation increases as fruit maturity advances and is highest in ripe fruit. The concentration of carotenoids in ripe durian pulp varies among cultivars. Ripening‐induced carotenoid accumulation is regulated by endogenous ethylene that controls the expression of key genes.
Corporate social responsibility and financial performance: Does country sustainability matter?
Authors: Vargas‐Santander Karen Gloria , Álvarez‐Diez Susana , Baixauli‐Soler Samuel , Belda‐Ruiz María 
Published: June 2023

AbstractDrawing on stakeholder and institutional theoretical frameworks, this study aims to examine how corporate social performance (CSP) impacts corporate financial performance (CFP) and the moderating role of country sustainability and its environmental (ENV), social (SOC) and governance (GOV) dimensions. Using a broad international sample with firms from 47 countries―and through multilevel and panel data analysis―results show a positive and significant influence of CSP on CFP, while country sustainability negatively moderates the CSP–CFP relationship. This is consistent with the idea that in countries with a high level of sustainability, firms have greater difficulty obtaining competitive advantages through actions related to corporate social responsibility. Results also indicate that country sustainability has a direct and positive impact on CFP (Tobin's‐Q), regardless of CSP. Additionally, applying country sustainability in a disaggregated manner, we find that social and governance dimensions influence the CSP–CFP relationship, while the environmental dimension does not. Evidence thus confirms that the effect of CSP on CFP varies depending on the institutional context in which the firm is located.
A novel low‐complexity model predictive control for Vienna rectifier
Authors: Sun Zhang , Jin Weidong , Wu Fan , Han Qi , Guan Kun , Ren Junxiao 
Published: June 2023

SummaryA Vienna rectifier is a kind of three‐phase converter with complex operation constraints. Traditional control methods suffer from poor dynamic responses and total harmonic distortion (THD), particularly when operating with adjustable wide‐range power. A novel low‐complexity model predictive control (LC‐MPC) algorithm is proposed based on the optimal switching vector sequence in this paper. First, a model predictive optimization control (MPOC) method is designed to search for the voltage vector sequence and its acting time. Second, the equivalent transformation and coordinate mapping of MPOC are efficiently achieved through the derived correlation factors and lookup table. Supported by the correlation factors, the redundant objective function calculation and repetitive online optimization are eliminated. Meanwhile, the simplified optimal over‐modulation strategy is implemented. Finally, the effectiveness and superiority of the algorithm are verified by comparative experiments. The results show that the proposed LC‐MPC is beneficial in terms of the computation time, dynamic response, over‐modulation, and harmonic content reduction.
Relation of modifiable lifestyle and mood factors to cognitive concerns among participants and their study partners in the A4 screen data
Authors: Reynolds Gretchen , Buckley Rachel , Papp Kathryn , Schultz Stephanie A. , Rentz Dorene , Sperling Reisa , Amariglio Rebecca 
Published: June 2023

AbstractIntroductionSubjective cognitive decline (SCD) has been associated with elevated amyloid levels and increased risk of future cognitive decline, as well as modifiable variables, including depression, anxiety, and physical inactivity. Participants generally endorse greater and earlier concerns than their close family and friends (study partners [SPs]), which may reflect subtle changes at the earliest stages of disease among participants with underlying neurodegenerative processes. However, many individuals with subjective concerns are not at risk of Alzheimer's disease (AD) pathology, suggesting that additional factors, such as lifestyle habits, may be contributory.MethodsWe examined the relation between SCD, amyloid status, lifestyle habits (exercise, sleep), mood/anxiety, and demographic variables among 4481 cognitively unimpaired older adults who are being screened for a multi‐site secondary prevention trial (A4 screen data; mean ±SD: age = 71.3 ±4.7, education = 16.6 ±2.8, 59% women, 96% non‐Hispanic or Latino, 92% White].ResultsOn the Cognitive Function Index (CFI) participants endorsed higher concerns compared to SPs. Participant concerns were associated with older age, positive amyloid status, worse mood/anxiety, lower education, and lower exercise, whereas SP concerns were associated with older participant age, male gender of participant, positive amyloid status of participant, and worse participant‐reported mood/anxiety.DiscussionFindings suggest that modifiable/lifestyle factors (e.g., exercise, education) may be associated with participant concerns among cognitively unimpaired individuals and highlight the importance of further examining how modifiable factors impact participant‐ and SP‐reported concerns, which may inform trial recruitment and clinical interventions.
Large offspring have enhanced lifetime reproductive success: Long‐term carry‐over effects of weaning size in gray seals (Halichoerus grypus)
Authors: Badger Janelle J. , Bowen W. Don , den Heyer Cornelia E. , Breed Greg A. 
Published: June 2023

AbstractAn individual's size in early stages of life may be an important source of individual variation in lifetime reproductive performance, as size effects on ontogenetic development can have cascading physiological and behavioral consequences throughout life. Here, we explored how size‐at‐young influences subsequent reproductive performance in gray seals (Halichoerus grypus) using repeated encounter and reproductive data on a marked sample of 363 females that were measured for length after weaning, at ~4 weeks of age, and eventually recruited to the Sable Island breeding colony. Two reproductive traits were considered: provisioning performance (mass of weaned offspring), modeled using linear mixed effects models; and reproductive frequency (rate at which a female returns to breed), modeled using mixed effects multistate mark–recapture models. Mothers with the longest weaning lengths produced pups 8 kg heavier and were 20% more likely to breed in a given year than mothers with the shortest lengths. Correlation in body lengths between weaning and adult life stages, however, is weak: Longer pups do not grow to be longer than average adults. Thus, covariation between weaning length and future reproductive performance appears to be a carry‐over effect, where the size advantages afforded in early juvenile stages may allow enhanced long‐term performance in adulthood.
Asymmetric interactions between two butterfly species mediated by food demand
Authors: Hashimoto Koya , Ohgushi Takayuki 
Published: June 2023

AbstractRecent studies on insect interactions on plants have revealed that herbivorous insects indirectly interact with each other through changes in plant traits following herbivory. However, less attention has been given to plant biomass relative to plant quality in relation to indirect interactions among herbivores. We explored the extent to which the larval food demand of two specialist butterflies (Sericinus montelaandAtrophaneura alcinous) explains their interaction on a host plant,Aristolochia debilis. A laboratory experiment showed that plant mass consumption byA. alcinouslarvae was 2.6 times greater than that byS. montela. We predicted thatA. alcinous, which requires more food, is more vulnerable to food shortages thanS. montela. In a cage experiment, an asymmetric interspecific interaction was detected between the two specialist butterflies;S. montelalarval density significantly decreased the survival and prolonged the development time ofA. alcinous, butA. alcinousdensity affected neither the survival nor the development time ofS. montela. The prediction based on the food requirement was partly supported by the fact that increasingA. alcinousdensity likely caused a food shortage, which more negatively affectedA. alcinoussurvival thanS. montelasurvival. Conversely, increasing the density ofS. monteladid not reduce the remaining food quantity, suggesting that the negative effect ofS. monteladensity onA. alcinouswas unlikely to be due to food shortage. Although aristolochic acid I, a defensive chemical specific toAristolochiaplants, did not influence the food consumption or growth of either butterfly larva, unmeasured attributes of plant quality may have mediated an indirect interaction between the two butterflies. Consequently, our study suggests that not only the quality but also the quantity of plants should be considered to fully understand the characteristics, such as symmetry, of interspecific interactions among herbivorous insects on the same host plant.
Potential variables forcing litterfall in a lower montane evergreen forest using Granger and superposed epoch analyses
Authors: Marod Dokrak , Andriyas Tushar , Leksungnoen Nisa , Kjelgren Roger , Thinkamphaeng Sathid , Chansri Piyawat , Asanok Lamthai , Hermhuk Sutheera , Kachina Panida , Thongsawi Jakkaphong , Phumphuang Wongsatorn , Uthairatsamee Suwimon , Racharak Phruet , Kaewgrajang Tharnrat 
Published: June 2023

AbstractThe interplay between long‐term environmental variability and litterfall is complex and through this study, we quantified the response of peak leaf, flower, and fruit litterfall production to such variability in a lower montane evergreen forest located in Doi Suthep‐Pui National Park, Thailand. We observed seasonality in litterfall accumulation with peak leaf and flower litterfalls occurring mostly during the cool and hot dry seasons, while fruit litterfall occurs mostly during the wet season. Probable associations with environmental drivers (barometric pressure, temperature, relative humidity, number of sunlight hours, evaporation, wind speed, and vapor pressure deficit) were tested on a 5‐year litter trap dataset using superposed epoch analysis and Granger causality tests. The tests indicated that significant deviations in barometric pressure, maximum temperature, maximum relative humidity, and wind speed were the most plausible precursors to peak litter production of all components. Additionally, we observed a lag in peak litterfall production relative to climate variability by up to 4 months for most of the climate variables. Changing environmental conditions can affect both the timing and amount of litterfall production, which in turn can alter the nutrient recycling rate and other essential ecosystem services of such forests.
Assessing the degradation of environmental DNA and RNA based on genomic origin in a metabarcoding context
Authors: Kagzi Kaushar , Millette Katie L. , Littlefair Joanne E. , Pochon Xavier , Wood Susanna A. , Fussmann Gregor F. , Cristescu Melania E. 
Published: June 2023

AbstractMolecular tools of species identification based on eNAs (environmental nucleic acids; environmental DNA [eDNA] and environmental RNA [eRNA]) have the potential to greatly transform biodiversity science. However, the ability of eNAs to obtain “real‐time” biodiversity estimates may be complicated by the differential persistence and degradation dynamics of the molecular template (eDNA or eRNA) and the barcode marker used. Here, we collected water samples over a 28‐day period to comparatively assess species detection using eDNA and eRNA metabarcoding of two distinct barcode markers—a mitochondrial mRNA marker (COI) and a nuclear rRNA marker (18S)—following complete removal of Arthropoda taxa in a semi‐natural freshwater system. Our findings demonstrate that Arthropoda community composition was largely influenced by marker choice, rather than molecular template, individual microcosm, or sampling time point. Furthermore, although eRNA may capture similar species diversity as the established eDNA method, this finding may be marker‐dependent. Although we found little to no difference in decay rates observed among sample groups (COI eDNA, COI eRNA, 18S eDNA, 18S eRNA), this result is likely due to limitations in the ability of eNA‐based metabarcoding to provide a strong correlation between true eNA copy numbers present in the environment and final read counts obtained (following the metabarcoding workflow). Collectively, our findings provide further support for the use of multi‐marker assessments in metabarcoding surveys to unravel the broadest taxonomic diversity possible, highlight the limitations of eNA metabarcoding methods in providing accurate decay rate estimates, as well as establish the need for further comparative studies using both metabarcoding and single‐species detection methods to assess the persistence and degradation dynamics of eNAs for a diverse range of taxa.
Ubiquitin‐specific protease 11‐mediated CD36 deubiquitination acts on C1q/TNF‐related protein 9 against atherosclerosis
Authors: Zeng Min , Wei Xin , He Yangli , Yang Yali 
Published: June 2023

AbstractAimsAtherosclerosis is a huge threaten to the human health, C1q/TNF‐related protein 9 (CTRP9) has been previously reported possessing vascular protective functions. Our study is aimed to reveal the mechanism of the regulative effects of CTRP9 on the foam cell formation.Methods and resultsPrimary human macrophages were isolated from human monocytes donated by healthy volunteers. CCK‐8 assay was performed for determining the cell viability. Oil Red O staining was employed for measuring the lipid accumulation. Cholesterol ester and cholesterol concentration were detected by commercial kits for evaluating the intracellular cholesterol. Ubiquitination assay was performed to reveal the ubiquitination level of CD36, cycloheximide assay was applied for determining the half‐life of CD36 protein. Quantitative real‐time PCR and western blot assays were performed for detecting the mRNA and protein expression. Pre‐treatment with CTRP9 in primary human macrophages markedly suppressed the cholesterol accumulation concentration after oxidized low‐density lipoprotein treatment. CD36 was significantly increased after oxidized low‐density lipoprotein exposure while was reduced by CTRP9 treatment. Up‐regulation of CD36 significantly reversed the CTRP9‐mediated protective effects in foam cells. The differential expression levels of several deubiquitinating enzymes preliminarily indicated that USP11 was obviously decreased after CTRP9 treatment. USP11 knockdown decreased the CD36 protein expression and pre‐treatment with 10 μg/mL MG132 significantly maintained the CD36 level from USP11 knock down. Up‐regulation of CD36 reversed the alterations on the cholesterol metabolism caused by CTRP9 or USP11 knockdown.ConclusionsCTRP9 regulates the USP11/CD36 axis to protect the macrophages form transforming into foam cells by suppressing intracellular lipid and cholesterol accumulation, which is a potential therapeutic agent for atherosclerosis.
Synthesis of Heterocycles from 2‐Acylbenzoic Acids
Authors: Liu Yu‐Feng , Li Cui , Yang Guo‐Ping 
Published: June 2023

AbstractHeterocyclics are the crucial scaffolds present in pharmaceuticals, natural products, biologically active compounds and agrochemicals. Consequently, the development of simple and practical methods for constructing heterocyclics has always been a fascinating field in organic synthesis. Recently, 2‐acylbenzoic acids, highly reactive and versatile synthons, have been broadly applied in the construction of heterocycles due to their multiple reaction sites. In this review, we summarized recent progress in the application of 2‐acylbenzoic acids for the synthesis of heterocycles including phthalides, isochromanones, isoindolines, phthalazinones, and quinolones. The substrate scopes, proposed mechanisms, and product application of different types of reactions are discussed.
Application of therate‐all‐that‐applymethod to explore the perception of flavours provided by e‐cigarettes: Importance of 1.3‐propanediol
Authors: Nhouchi Zeineb , Belay Justine , Hanaei Farnaz , Vallet Nadine 
Published: June 2023

AbstractThe self‐administration of nicotine using e‐cigarettes involves the use of liquids containing both solvent and aroma. The vaping appeal is enhanced by the sensory perception of flavours. Thus, an important attention may be paid to the choice of the refill liquid. For this purpose, this study aimed to evaluate the potential of 1,3‐propanediol (PDO, vegetal solvent) and 1,3‐butanediol (BDO, vegetal solvent), in replacing the chemical one such 1,2‐propanediol (PG) while maintaining sensory pleasure and ensuring the wellbeing. The work was conducted with 30 participants accustomed to vaping. Three flavours have been selected, menthol, vanillin and pyrazine, respectively, to provide the most preferred perceptions which are respectively mint, sweet and tobacco. TheRate‐All‐That‐Apply (RATA) method was chosen since it is rapid and robust. Menthol/PDO and menthol/PG exhibited a close olfactive profile, described as minty, cold and sweet. A similar finding has been observed for vanillin/PDO and vanillin/PG. The use of BDO provided different perceptions in comparison with PDO and PG regardless of the type of flavour. It was found to be the most suitable for pyrazine perception. These results were enhanced by the application of the agglomerative hierarchical clustering (AHC). The obtained dendrogram was composed of three groups according to their similarities, where e‐liquids containing PDO, and PG belongs to the same groups for both menthol and vanillin.