bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on destabilization failure characteristics and energy evolution law of drilling holes
Authors: Wang Yang , Xu Mengtang , Kong Dezhong , Wu Guiyi , Shang Yuqi , Chen Long , Liu Yuhao 
Published: June 2023

AbstractBorehole destabilization damage is an important factors affecting gas extraction efficiency. To derive the fracture development law, strain, and energy evolution characteristics of different borehole diameters, uniaxial compression experiments were conducted on prefabricated rock specimens with different borehole diameters. The results showed that the elastic energy and dissipation energy of the specimens with different pore diameters changed with the compression process, and the energy distribution inside the specimens. The results show that as the pore size of the specimen increases, the strain area damaged by tensile fracture gradually decreases and the strain area damaged by shear fracture gradually increases, and the damage of the dominant specimen gradually evolves from tensile fracture as the dominant factor to tensile fracture and shear fracture together as the dominant factor and finally to shear fracture as the dominant factor. For the whole compression process of pore size rock specimens, the total energy curve shows a nonlinear growth trend, and the elastic energy curve shows a nonlinear growth trend before the specimen damage and a cliff‐type decrease after the specimen damage. From the perspective of energy distribution, the elastic energy storage limit of the specimen decreases with the increase of the specimen pore size, the energy distribution law inside the rock specimen with pores changes, and the total energy absorbed from the outside gradually changes to the dissipated energy, resulting in an increasing proportion of dissipated energy, indicating that the larger the pore size, the larger the plastic deformation, and the more obvious ductile damage characteristics of the specimen with pores will be shown. The research analyzes the causes of destabilization of rock samples with different hole diameters and provides some theoretical guidance for the study of gas extraction drilling stability.
An Assessment of the Toxicity of Pesticide Mixtures in Periphyton from Agricultural Streams to the Mayfly Neocloeon triangulifer
Authors: Ijzerman Moira M. , Raby Melanie , Izma Gab B. , Kudla Yaryna M. , Letwin Nicholas V. , Gallant Melanie J. , Schiffer Stephanie R. , Atkinson Brian J. , Rooney Rebecca C. , Sibley Paul K. , Prosser Ryan S. 
Published: June 2023

Abstract
Residual concentrations of pesticides are commonly found outside the intended area of application in Ontario's surface waters. Periphyton are a vital dietary component for grazing organisms in aquatic ecosystems but can also accumulate substantial levels of pesticides from the surrounding water. Consequently, grazing aquatic organisms are likely subjected to pesticide exposure through the consumption of pesticide-contaminated periphyton. The objectives of the present study were to determine if pesticides partition into periphyton in riverine environments across southern Ontario and, if so, to determine the toxicity of pesticides in periphyton when fed to the grazing mayfly Neocloeon triangulifer. Sites with low, medium, and high pesticide exposure based on historic water quality monitoring data were selected to incorporate a pesticide exposure gradient into the study design. Artificial substrate samplers were utilized to colonize periphyton in situ, which were then analyzed for the presence of approximately 500 pesticides. The results demonstrate that periphyton are capable of accumulating pesticides in agricultural streams. A novel 7-day toxicity test method was created to investigate the effects of pesticides partitioned into periphyton when fed to N. triangulifer. Periphyton collected from the field sites were fed to N. triangulifer and survival and biomass production recorded. Survival and biomass production significantly decreased when fed periphyton colonized in streams with catchments dominated by agricultural land use (p &lt; 0.05). However, the relationship between pesticide concentration and survival or biomass production was not consistent. Using field-colonized periphyton allowed us to assess the dietary toxicity of environmentally relevant concentrations of pesticide mixtures; however, nutrition and taxonomic composition of the periphyton may vary between sites. Environ Toxicol Chem 2023;42:2143–2157. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Predicting Environmental Risks of Pharmaceuticals from Wholesale Data: An Example from Norway
Authors: Welch Samuel A. , Moe S. Jannicke , Sharikabad Mohammad N. , Tollefsen Knut Erik , Olsen Kristine , Grung Merete 
Published: June 2023

Abstract
Environmental risk assessment (ERA) of pharmaceuticals relies on available measured environmental concentrations, but often such data are sparse. Predicted environmental concentrations (PECs), calculated from sales weights, are an attractive alternative but often cover only prescription sales. We aimed to rank, by environmental risk in Norway, approximately 200 active pharmaceutical ingredients (APIs) over 2016–2019, based on sales PECs. To assess the added value of wholesale and veterinary data, we compared exposure and risk predictions with and without these additional sources. Finally, we aimed to characterize the persistence, mobility, and bioaccumulation of these APIs. We compared our PECs to available Norwegian measurements, then, using public predicted-no-effect concentrations, we calculated risk quotients (RQs) and appended experimental and predicted persistence and bioaccumulation. Our approach overestimated environmental concentrations compared with measurements for 18 of 20 APIs with comparable predictions and measurements. Seventeen APIs had mean RQs &gt;1, indicating potential risk, while the mean RQ was 2.05 and the median 0.001, driven by sex hormones, antibiotics, the antineoplastic abiraterone, and common painkillers. Some high-risk APIs were also potentially persistent or bioaccumulative (e.g., levonorgestrel [RQ = 220] and ciprofloxacin [RQ = 56]), raising the possibility of impacts beyond their RQs. Exposure and risk were also calculated with and without over-the-counter sales, showing that prescriptions explained 70% of PEC magnitude. Likewise, human sales, compared with veterinary, explained 85%. Sales PECs provide an efficient option for ERA, designed to overestimate compared with analytical techniques and potentially held back by limited data availability and an inability to quantify uncertainty but, nevertheless, an ideal initial approach for identification and ranking of risks. Environ Toxicol Chem 2023;42:2253–2270. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Energy efficiency augmentation inUWA‐OFDMtransducer by peak to average power ratio alleviation through hybrid companding approach
Authors: Banoori Farhad , Shi Jinglun , Khan Khalid , Arshad Jehangir , Liu Xiongying , Muhammad Noman Sohail , Irshad Muhammad 
Published: June 2023

AbstractOrthogonal frequency division multiplexing (OFDM) is a compelling contender for next‐generation fixed and wireless standards to realize high data transmission rates in underwater acoustic (UWA) systems. A specific challenge before transmission over the transducers of the UWA system within an OFDM signal is the high peak to average power ratio (PAPR), which severely affects the energy efficiency of the UWA system. This work aims to enhance the energy efficiency of the UWA system by alleviating the stumbling block mentioned earlier within the OFDM. Moreover, we recommend and design a methodology that incorporates modified repeated frequency‐domain filtering and clipping (RFC) and companding techniques to restrain the PAPR obstacle. Additionally, the modified RFC utilizes various companding techniques (including linear and nonlinear techniques) to achieve the desired objectives without complexity augmentation of the system. We simulate and test our proposed approach against four major parameters: PAPR, bit error rate, energy efficiency, and system performance gain. Statistical results show that our technique offers .36 high‐power amplifier power efficiency (), which is comparatively better than OFDM with selective mapping, OFDM with partial transmit sequences, and OFDM with other hybrid approaches.
Methodological innovations within the RAWES framework for use in development scenarios
Authors: Cianchi Ben , Everard Mark , McInnes Rob , Cooke Rob 
Published: June 2023

Abstract
Built development changes the nature of land and its ecosystems, with diverse ramifications for human well-being and the resilience of the socioecological system. Robust and replicable approaches are required to assess ecosystem services generated by sites both predevelopment and for evaluation of postdevelopment options, to assess change and to support a paradigm shift from a “do less harm” to a “regenerative” approach. The Rapid Assessment of Wetland Ecosystem Services (RAWES) approach provides an internationally recognized methodology for systemic assessment of the ecosystem services generated by a site, taking account of all ecosystem services and service categories across multiple spatial scales. The RAWES assessments of constituent ecosystem services can be combined into Ecosystem Service Index scores. This article outlines innovations in RAWES methods to assess changes in ecosystem services likely to result from differing development scenarios in the context of a case study site in eastern England. These adaptations of the RAWES approach include revised methods for the analysis of ecosystem service beneficiaries across multiple spatial scales, the establishment of a common baseline against which to compare likely ecosystem service outcomes under a range of development scenarios, and a standardized method for accounting for supporting services through their contributions to other more directly exploited services. Integr Environ Assess Manag 2024;20:189–200. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Dexmedetomidine attenuates inflammation and organ injury partially by upregulating Nur77 in sepsis
Authors: Zhang Qian , Huang Yun , Gong Chenchen , Tang Yan , Xiong Jie , Wang Difen , Liu Xu 
Published: June 2023

AbstractPurposeThe aim of this study was to investigate the effect of dexmedetomidine (Dex) on inflammation and organ injury in sepsis, as well as the potential relationship between Dex and nuclear receptor 77 (Nur77).MethodsWe investigated the effects of dexmedetomidine on lipopolysaccharide (LPS)‐induced inflammation in RAW264.7 cells and organ injury in the cecal ligation and puncture (CLP) mouse model. Additionally, we examined the relationship between dexmedetomidine and Nur77. The expression levels of Nur77 in RAW264.7 cells were analyzed under various types of stimulation using quantitative reverse transcription polymerase chain reaction and western blot analysis. Inflammatory cytokine levels in the cells were evaluated using enzyme‐linked immunoassay. Organ injuries were assessed by examining tissue histology and pathology of the lung, liver, and kidney.ResultsDexmedetomidine increased the expression of Nur77 and IL‐10, and downregulated inflammatory cytokines (IL‐1β and TNF‐α) in LPS‐treated RAW264.7 cells. The effect of dexmedetomidine on inhibiting inflammation in LPS‐treated RAW264.7 cells was promoted by overexpressing Nur77, while it was reversed by downregulating Nur77. Additionally, dexmedetomidine promoted the expression of Nur77 in the lung and CLP‐induced pathological changes in the lung, liver, and kidney. Activation of Nur77 with the agonist Cytosporone B (CsnB) significantly suppressed the production of IL‐1β and TNF‐α in LPS‐treated RAW264.7 cells. In contrast, knockdown of Nur77 augmented IL‐1β and TNF‐α production in LPS‐treated RAW264.7 cells.ConclusionDexmedetomidine can attenuate inflammation and organ injury, at least partially, via upregulating Nur77 in sepsis.
Pregnancy outcomes following radical trachelectomy for early‐stage cervical cancer: A retrospective observational study in the Kanto area, Japan
Authors: Kasuga Yoshifumi , Hasegawa Keita , Hamuro Asuka , Fukuma Yuka , Tamai Junko , Tanaka Yuya , Ikenoue Satoru , Tanaka Mamoru 
Published: June 2023

AbstractObjectiveThe authors aimed to investigate the prevalence of pregnancy and obstetric outcomes in patients who underwent radical trachelectomy (RT) for early‐stage cervical cancer in the Kanto area, Japan.MethodA survey among 113 perinatal centers affiliated with the Kanto Society of Obstetrics and Gynecology was conducted to investigate their experience in managing pregnancies following RT, between 2010 and 2020. The association between preterm delivery (before 34 gestational weeks) and a midtrimester short cervix (<13 mm) was evaluated.ResultsThe authors retrospectively collected maternal and perinatal data from 13 hospitals. There were 135 pregnancies among 115 women following RT. Of the 135 pregnancies, 32 were miscarriages (<12 gestational weeks: n = 22; >12 gestational weeks: n = 10), and 103 were delivered after 22 gestational weeks. The incidences of preterm delivery before 28 and 34 gestational weeks were 8.7% and 30.1%, respectively. A midtrimester short residual cervix was associated with preterm delivery (P = 0.046).ConclusionSince more than 100 pregnancies were recorded after RT in the Kanto area, many physicians had more opportunities to manage pregnancy after RT. Pregnancy following RT is associated with increased risk of preterm delivery, and midtrimester short residual cervix is a good predictor of preterm delivery.
Evaluation of multigenerational effects of 2‐ethylhexyl 4‐hydroxybenzoate in Japanese medaka
Authors: Matten Sharlene , Fallacara Dawn , Kamel Alaa , Lynn Scott G. , Fort Douglas J. , Wolf Jeffrey C. , Leak Tom , von Holst Haley , Bever Ronnie Joe , Thomas Amy , Brown Vincent J. 
Published: June 2023

AbstractThe Japanese medaka (Oryzias latipes) extended one‐generation reproduction test (MEOGRT) (Test Guideline 890.2200) is a Tier 2 test within the Endocrine Disruptor Screening Program of the US Environmental Protection Agency (US EPA). A modified MEOGRT was used to evaluate multigenerational effects of 2‐ethylhexyl 4‐hydroxybenzoate (2‐EHHB) under flow‐through conditions starting with adults (parent generation, F0) through a 3‐week reproductive phase of the second generation (F2). Fish were exposed to one of five 2‐EHHB test concentrations or a dechlorinated tap water control. Fecundity was affected at the lowest exposure (5.32 μg/L) and greater sensitivity occurred in the F1 and F2 generations. Percent fertility was also diminished from no effect level observed in the F0 generation to 101 and 48.8 μg/L in the F1 and F2 generations, respectively. Growth indices were decreased for F0 adult females and F1 subadults and adults at 48.8 μg/L 2‐EHHB. Histopathologic examination of gonads, liver, kidney, and thyroid yielded possible delayed reproductive tract development in F1 subadult males, masculinization of the renal phenotype in F1 adult females (renal tubular eosinophilia) and reduced hepatic energy storage (liver glycogen vacuoles) in F1 (11.3 and 48.8 μg/L) and F2 (48.8 and 101 μg/L) males and females, respectively. Endocrine‐related findings included a decrease in anal fin papillae in F2 adult males at 101 μg/L. Results of this study demonstrate effects on growth, development, and reproduction that may be mediated by endocrine (weak estrogenic) and nonendocrine mechanisms. Duration of the MEOGRT should not be routinely extended beyond the OCSPP 890 guideline study design.
Identification and interpretation of TET2 noncanonical splicing site intronic variants in myeloid neoplasm patients
Authors: Das Riku , Tu Zheng Jin , Bosler David S. , Cheng Yu‐Wei 
Published: June 2023

AbstractBackground: DNA hypermethylation and instability due to inactivation mutations in Ten–eleven translocation 2 (TET2) is a key biomarker of hematological malignancies. This study aims at characterizing two intronic noncanonical splice‐site variants, c.3954+5_3954+8delGTTT and c.3954+5G>A.Methods: We used in silico prediction tools, reverse transcription (RT)‐PCR, and Sanger sequencing on blood/bone marrow‐derived RNA specimens to determine the aberrant splicing.Results: In silico prediction of both variants exhibited reduced splicing strength at the TET2 intron 7 splicing donor site. RT‐PCR and Sanger sequencing identified a 62‐bp deletion at the exon 7, producing a frameshift mutation, p.Cys1298*.Conclusion: This study provides functional evidence for two intronic TET2 variants that cause alternative splicing and frameshift mutation.
Characterization of chrysoberyl and its gemmological varieties by Raman spectroscopy
Authors: Rybnikova Olena , Bačík Peter , Uher Pavel , Fridrichová Jana , Lalinská‐Voleková Bronislava , Kubernátová Monika , Hanus Radek 
Published: June 2023

AbstractVarious chrysoberyl varieties (non‐phenomenal chrysoberyl, alexandrite and cymophane) are gemstones of high demand; therefore, they are subjected to numerous substitutions by other materials and synthetic analogues. To address this issue, non‐destructive methods for studying gemstones are highly sought after. Raman spectroscopy is one of the most suitable non‐destructive methods for studying gemstones as it requires no sample preparation and does not leave any price‐reducing signs on the gemstone surface. The research is focused on Raman spectroscopy application on chrysoberyl identification, differentiation between its varieties, inclusion analysis, and detection of synthetic analogues and imitations. The alexandrite variety can be identified by its broad luminescence band that ranges from 640 to 790 nm (15 625–12 658 cm−1). Synthetic alexandrite has sharper and more intensive bands on the luminescence spectrum, especially 690 and 696 nm (14 492–14 367 cm−1). Rutile inclusions can be distinguished by a broad band 580–640 cm−1 in the Raman spectrum. Imitations of chrysoberyl represented by corundum and colour‐changing spessartine was also identified. The orientation of faceted stones can also be determined by specific bands present in the Raman spectrum.
Efforts to improve the surgical outcome for exotropia and investigation of the insertion locations of the extraocular muscles
Authors: Lai Yu‐Hung , Chang Shun‐Jen 
Published: June 2023

AbstractIn our previous retrospective study, we found that using the strabismus surgery dosages established by western strabismus mentors tends to result in undercorrection of Taiwanese exotropia (XT) patients compared with those in western populations. We also discovered that the location of extraocular muscle (EOM) insertion could vary by ethnicity. In this study, using a generalized estimation equation model, we compared the XT surgery outcome between augmented and original strabismus surgery dosages in Taiwanese patients. We also conducted an observational study to investigate the horizontal EOM insertion location in a Taiwanese population and compared the data with Dr. Apt L.'s study. For Taiwanese XT patients, augmented surgical dosages resulted in significantly better outcome at 6 months and 1 year postoperatively compared with original surgical dosages (p = 0.003 and p < 0.001, respectively). The distance from the lateral recuts muscle (LR) insertion location to the limbus was significantly shorter in Taiwanese than in white Americans (6.5 vs. 6.9 mm, respectively, p = 0.0001). Furthermore, the medial rectus muscle and LR insertion locations differed significantly between males and females (p < 0.001 and p = 0.023, respectively). The patients' sex did not affect the surgery outcome. Augmented surgery doses modified from western strabismus mentors produce better surgery outcome for Taiwanese XT patients. Surgeons may require country‐specific guidelines for strabismus surgery dosage. We also demonstrated a simple method for young ophthalmologists to establish their own normograms to improve their surgical success rate. Our study confirms that LR insertion locations differ between Taiwanese and White Americans.
Analyzing County‐level Social Vulnerabilities of Head and Neck Melanomas in the United States
Authors: McCampbell Lillian , Fei‐Zhang David Jun , Chelius Daniel , Rastatter Jeff , Sheyn Anthony 
Published: June 2023

ObjectivesStudies addressing social determinants of health (SDH) in head–neck melanomas (HNM) have only assessed incidence with increasing socioeconomic status. None have investigated a wider scope of SDH or their summed influence on affecting HNM prognosis and follow‐up care.MethodsThis retrospective cohort study analyzed 374,138 HNM in adults from 1975 to 2017 from the NCI‐Surveillance, Epidemiology, and End Results Program (NCI‐SEER) database. Utilizing the NCI‐SEER database, Social Vulnerability Index (SVI) scores were matched to county of residence upon diagnosis. Univariate linear regressions were performed on length of care (months of follow‐up/surveyed) and prognosis (months survival) across various SDH/SVI scores of socioeconomic status, minority and language status, household composition, housing and transportation, and their total composite.ResultsWith increasing overall SVI score, which indicates increasing social vulnerability, months of follow‐up showed significant decreases ranging from 0.04% to 27.63% compared with the lowest vulnerability groups, with the highest differences in nodular melanomas and the lowest with malignant melanomas in giant pigmented nevi. Similarly, months survival significant decreases ranged from 0.19% to 39.84% compared with the lowest SVI scores, with the highest difference in epithelioid cell melanomas and the lowest in amelanotic melanoma. Comprising this overall score trend, decreases with socioeconomic status, minority‐language status, household composition, and housing‐transportation contributed differentially per histology subtype.ConclusionsOur data highlight significant negative trends in HNM prognosis and care with higher total social vulnerability while showing which SDH‐themes quantifiably contribute more to these differences.Level of Evidence3 Laryngoscope, 134:185–190, 2024