bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Transformation in the Diagnostics and Therapy of Cardiovascular Diseases: Comprehensive Literature Review
Authors: Stremmel Christopher , Breitschwerdt Rüdiger 
Published: August 2023

Background
The digital transformation of our health care system has experienced a clear shift in the last few years due to political, medical, and technical innovations and reorganization. In particular, the cardiovascular field has undergone a significant change, with new broad perspectives in terms of optimized treatment strategies for patients nowadays.

Objective
After a short historical introduction, this comprehensive literature review aimed to provide a detailed overview of the scientific evidence regarding digitalization in the diagnostics and therapy of cardiovascular diseases (CVDs).

Methods
We performed an extensive literature search of the PubMed database and included all related articles that were published as of March 2022. Of the 3021 studies identified, 1639 (54.25%) studies were selected for a structured analysis and presentation (original articles: n=1273, 77.67%; reviews or comments: n=366, 22.33%). In addition to studies on CVDs in general, 829 studies could be assigned to a specific CVD with a diagnostic and therapeutic approach. For data presentation, all 829 publications were grouped into 6 categories of CVDs.

Results
Evidence-based innovations in the cardiovascular field cover a wide medical spectrum, starting from the diagnosis of congenital heart diseases or arrhythmias and overoptimized workflows in the emergency care setting of acute myocardial infarction to telemedical care for patients having chronic diseases such as heart failure, coronary artery disease, or hypertension. The use of smartphones and wearables as well as the integration of artificial intelligence provides important tools for location-independent medical care and the prevention of adverse events.

Conclusions
Digital transformation has opened up multiple new perspectives in the cardiovascular field, with rapidly expanding scientific evidence. Beyond important improvements in terms of patient care, these innovations are also capable of reducing costs for our health care system. In the next few years, digital transformation will continue to revolutionize the field of cardiovascular medicine and broaden our medical and scientific horizons.
SAÚDE NA ESCOLA E SUAS TECNOLOGIAS: um levantamento sobre o currículo dos cursos de Pedagogia do Brasil
Authors: Brito Antonia Janieiry Ribeiro da Silva , Nascimento Karla Angélica Silva do 
Published: August 2023

O presente estudo teve como objetivo analisar a relação Educação e Saúde nos currículos dos cursos de Pedagogia do Brasil para promoção da saúde na escola. De abordagem qualitativa, descritiva, do tipo pesquisa documental, o estudo analisou, como fonte, as informações disponíveis no e-MEC, sistema criado para tramitar os processos de regulamentação das instituições de ensino superior no credenciamento e recredenciamento de cursos. Dos 1.968 cursos de Pedagogia ativos no Brasil, foram analisados 396, com base no cálculo amostral com nível de confiança de 99% e margem de erro de 6. Os resultados mostram que há uma real necessidade de investimento na formação inicial relacionada à Educação e Saúde, visto que os(as) profissionais de ensino precisam também conhecer, planejar e desenvolver estratégias de ensino voltadas aos aspectos saudáveis das crianças na educação básica. Conclui-se que o autodidatismo é insuficiente para a promoção da saúde na escola, bem como para utilização de tecnologias voltadas à mediação didática dessa área de estudo. Por isso, a importância de prover momentos formativos coletivos para a formação inicial e continuada.
White spot lesions in orthodontics: consensus statements for prevention and management
Authors: Sardana Divesh , Schwendicke Falk , Kosan Esra , Tüfekçi Eser 
Published: August 2023

ABSTRACT

Objective
To establish consensus recommendations for clinicians to manage white spot lesions (WSLs) during orthodontic treatment.

Materials and Methods
Three task force members reviewed the literature to identify best practices for minimizing WSLs during orthodontic treatment. Each draft statement was read to the task force members by a facilitator, followed by voting, accepting, or editing if necessary. The statements were then sent electronically by an independent third party (Magellan Medical Technology Consultants Inc, Minneapolis, Minn) to a previously formed content validation panel consisting of 20 independent private practitioners and clinical academicians for validation.

Results
Twenty-one statements were developed and sent for content validation. While 19 statements achieved a content validation index (CVI) of 0.78, two items did not. These items were edited by the task force members based on qualitative feedback from content validation participants. Each of these revised statements did achieve a CVI of 0.78 on second evaluation from the content validation panelists and therefore were included in this document.

Conclusion
To reduce the risk of WSLs, it is essential to implement individualized caries management measures based on a comprehensive assessment of the patient’s oral and systemic health. Effective at-home and professional mechanical and chemical plaque control should be implemented for high-risk orthodontic patients. Fluoride to support prevention and materials such as orthodontic sealants should also be used to provide a physical barrier around the brackets in high-risk patients. By following these guidelines, orthodontic professionals can help promote oral health and minimize the need for restorative treatment.
Leisure-time physical activity and risk of microvascular complications in individuals with type 2 diabetes: A UK Biobank study
Authors: Pagh Bredahl Kristensen Frederik , Adriano Sanchez-Lastra Miguel , Dalene Knut Eirik , Cruz Borja del Pozo , Ried-Larsen Mathias , Thomsen Reimar Wernich , Ding Ding , Ekelund Ulf , Tarp Jakob 
Published: August 2023

<p> </p>
<p>OBJECTIVE</p>
<p>We aimed to determine dose-response associations, including the minimal effective level, between leisure-time physical activity and risk of incident neuropathy, nephropathy, and retinopathy.</p>
<p>RESEARCH DESIGN AND METHODS</p>
<p>This cohort study included 18,092 individuals with type 2 diabetes from the UK Biobank. Self-reported leisure-time physical activity was converted into metabolic equivalent of task-hours/week (MET-hrs). Participants were categorised into no physical activity (0 MET-hrs/week), below recommendations (>0-7.49 MET-hrs/week), at recommendations (7.5-14.9 MET-hrs/week), and above recommendations (≥15 MET-hrs/week). Microvascular complications were identified from hospital inpatient records using diagnosis codes. We used Cox regression analysis to calculate adjusted hazard ratios (aHR) and restricted cubic splines to identify the minimal effective level of physical activity.</p>
<p>RESULTS</p>
<p>During a median follow-up of 12.1 years, 672 individuals (3.7%) were diagnosed with neuropathy, 1,839 (10.2%) with nephropathy, and 2,099 (11.7%) with retinopathy. Any level of physical activity was associated with a lower risk of neuropathy and nephropathy, but not retinopathy. Compared with those reporting no physical activity, the aHR of neuropathy was 0.71 (0.53-0.90) below recommendations, 0.73 (0.56- 0.96) at recommendations, and 0.67 (0.52-0.87) above recommendations. Corresponding aHRs for nephropathy were 0.79 (0.68-0.92), 0.80 (0.67-0.95), and 0.80 (0.68-0.95). The association with retinopathy was weaker: 0.91 (0.78-1.06), 0.91 (0.77-1.08), and 0.98 (0.84-1.15). </p>
<p>CONCLUSIONS</p>
<p>Any level of leisure-time physical activity was associated with a lower risk of neuropathy and nephropathy but not retinopathy in individuals with type 2 diabetes. For both neuropathy and nephropathy, the minimal effective physical activity level may correspond to less than 1.5 hours of walking/week.</p>
Status of Freshwater Aquaculture in Gujarat: A Trend Analysis and Potential
Authors: Chaudhari A. K. , Ail Sunil Kumar S. , Misra C. K. , De H. K. , Rathod Ramesh , Bhatt J. H. , Swain S. K. 
Published: August 2023

This study was undertaken during 2022 in the Regional Research Center of ICAR-Central Institute of Freshwater Aquaculture, Anand, Gujarat, India to study the present status and potential in the development of freshwater aquaculture in the state of Gujarat. The present seed production (2608.37 million fry) and Inland fish production (0.158 MT) in Gujarat is forecasted to reach 3100 million fry and 0.22 MT in 2030; 4600 million fry and 3.14 MT in 2050, respectively. The Regional Research station of ICAR-CIFA had contributed significantly in promoting aquaculture by imparting skill training and providing technical backup to fish farmers. Authors argue that in order to further develop freshwater aquaculture value chain, concerted efforts are required to disseminate technology packages for fish breeding and seed rearing, semi-intensive culture practices, diversified fish farming, scientific management (fish feed and nutrition, water quality and fish health), ornamental fish farming, pearl production and cluster-based fish farming. However, successful implementation of suggested points will be depending on the sustainable adaptive capacity of the freshwater aquaculture producers, entrepreneurs, strategies and planning of policy makers and line departments of various state departments, input dealers and buyers in the state of Gujarat. Hence, they need to be supported in terms of skill, policy and market towards establishing a vibrant fish value chain. Therefore, adoption of BMPs, nurturing entrepreneurs, aggregating farmers and strengthening extension services are recommended.
Genotypic Difference in Growth and Physiological Indices of Grain Amaranth Species under Salinity Stress
Authors: Ramani Divyesh H. , Singh Anuj Kumar , Prajapati Nitesh N. , Tiwari Kapil Kumar , Bhadauria Hitendra S. 
Published: August 2023

The present experiment was conducted during October to February of year 2019−20, to investigate the effect of salinity on morpho-physiological traits and identify the genotype have higher salt tolerance among ten genotypes belongs to three grain Amaranth species. Plant growth traits viz., plant height, shoot and root dry weight decreases with increase in the salinity stress level (EC of 5 and 10 dS m-1) in all the genotypes, however significant (p<0.01) genotypic difference were present among genotypes and GA-5 maintained the maximum growth under salinity. Percent decrease in SDW and RDW was lowest (10.61−23.86 and 10.37 and 26.59) in A. hypochondriachus while in A. cruentus (15.10-29.55 and 12.78-33.09) and A. caudatus (15.15−28.84 and 16.62-34.90). Salinity significantly (p<0.01) decreases the membrane stability, relative water content and leaf potassium content while, leave sodium content increases. As compared to other genotype GA-5 have maximum membrane stability (53.30), relative water content (85.40%), K+ accumulation and minimum Na+ accumulation in leaves.Morpho-physiological traits of grain Amaranthus species are significantly positively correlated with dry shoot biomass (0.649), MSI (0.770), RWC (0.768), chlorophyll (0.908), carotenoid (0.883) and leaf potassium (0.883). It might be concluded that among studied genotypes GA-5 maintained the growth and have higher physiological efficiency results into maximum salt tolerance index also morpho-physiological traits like dry weight, RWC, MSI, Chlorophyll, Carotenoid and leaf potassium content might be utilised for selection of salt tolerant Amaranth genotypes.
Studies on Correlation and Path Analysis for Yield and Morpho-Physiological Traits in Elite Rice (Oryza sativa L.) Genotypes under Dry DSR System
Authors: Md. Farheen  , Murthy K. Gopala Krishna , Mohan Y. Chandra , Kumar J. Hemantha 
Published: August 2023

An experiment was conducted at the Agricultural College, Aswaraopet, Bhadradri Kothagudem district, Telangana, India during July to December 2021 by using thirty elite rice genotypes comprising of different durations i.e. short, medium and long to study the nature of relationship between grain yield and morpho-physiological traits by partitioning the correlation co-efficients between grain yield and morpho-physiological traits into direct and indirect effects. Observations were recorded on seven yield, six physiological and three root characters. The correlation studies revealed that, grain yield plant-1 had shown a significant positive association with yield contributing traits like 1000 grain weight, spikelet fertility, specific leaf area and root biomass, indicating the importance of these traits in yield improvement. Among all other yield attributing characters, spikelet fertility showed the highest significant positive correlation with yield whereas days to 50% flowering and number of productive tillers plant-1 exhibited non-significant positive association with grain yield plant-1. Path coefficient analysis revealed that the highest positive direct effect on grain yield was exhibited by spikelet fertility and 1000 grain weight. A high magnitude of negative direct effects on yield was shown by field emergence at 14 DAS. Thus, from the studies on correlation and path analysis, it could be concluded that the traits viz., spikelet fertility, 1000 grain weight, specific leaf area and root biomass could be used as selection parameters for improving grain yield under dry DSR system.
Isolation and Antifungal Susceptibility of Candida spp. from Pediatric Patients in Kurdistan of Iraq
Authors: Bahi Mohammed Salah , Mustafa Shekhany Khattab Ahmed 
Published: August 2023

Candida species are considered the most common opportunistic human fungal pathogen due to the presence of various virulence factors, including its ability to form a biofilm that aids in oral candidiasis. Pediatric patients are more susceptible to oral candidiasis than healthy pediatric because of the factors that encourage Candida oral carriage. This current study aims to isolate, evaluated the antifungal effect on Candida spp. and participated in oral candidiasis of pediatric patients in Sulaymaniyah and Kirkuk city. The study was performed from September 2021 to February 2022 on two groups of pediatrics which including pediatric patients (n=160) and healthy pediatric (n=50) as a control group. Oral swabs were obtained from 210 participants in the Kurdistan Region of Iraq at the Pediatric teaching hospital of the Sulaymaneyah and Kirkuk governorates. To culture the swabs, Sabouraud dextrose agar (SDA) medium was used. HiCrome™ Candida Differential agar used to identify Candida isolated, then depending on the internal transcribed spacer (ITS) region using confirmed polymerase chain reaction. Antifungal sensitivity was done for all C. albicans and non-albicans isolates using five common antifungal disks. Among of the 160 sample of pediatric patient 62 (38.8%) positive for Candida spp. which it is including 17 (27.4 %) and 26 (41.9%), 19 (30.6%) breast feeding, bottle feeding and mixing respectively. While within 50 samples of control group 13 (26%) were positive for Candida spp. which including 2 (15.4%), 9(69.2%), 2(15.4%) of same respectively feeding types. Regarding to the antifungal susceptibility the results showed that C. albicans had higher resistance rates against itraconazole, ketoconazole, and clotrimazole than the non-albicans Candida species However, highly resistant rate were detected in Itraconazole and Ketoconazole with 23.7% and 54.4% respectively, for all Candida species. The Current study concluded that oral candidiasis was more predominant in pediatric patients in compare to healthy pediatric also, and C. albicans is the most prevalent etiologic agent. However, higher rate of sensitivity were detected between Candida species for nystatin, which may suggest as the main treatment for oral Candida infections.
Incidence and associated factors of congenital syphilis at a tertiary care center in Thailand
Authors: Kulsirichawaroj Pimchanok , Lumbiganon Dissajee 
Published: August 2023

Abstract

Background:
The incidence of congenital syphilis is increasing worldwide, in parallel with the increase of syphilis in the general population.

Objectives:
This study aimed to determine the incidence and risk factors for congenital syphilis at a referral tertiary care center in Bangkok, Thailand.

Methods:
This is a case–control study using the hospital medical records of neonates born at our hospital, whose mothers had confirmed syphilis during pregnancy or at delivery between 2011 and 2018. Maternal and neonatal data were reviewed. Neonates were categorized into congenital syphilis according to CDC surveillance case definition for congenital syphilis 2015 and the American Academy of Pediatrics Congenital Syphilis 2018: confirmed and probable were assigned to the case group, while possible and less likely congenital syphilis were used as the control group. Factors associated with congenital syphilis were analyzed using univariable and multivariable analysis.

Results:
Among 19,558 live births, there were 126 neonates born to mothers with syphilis. Almost 40% of mothers were teenage mothers and 48.4% had inadequate or no syphilis treatment. Forty neonates met the criteria of congenital syphilis giving the incidence of 204 per 100,000 live births (95% confidence interval [CI]: 146–278). Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth (adjusted odd ratio [aOR]: 2.69, 95% CI: 1.02–7.11, P = 0.046 and aOR: 2.91; 95% CI: 1.01–8.39, P = 0.049, respectively).

Conclusions:
The incidence of congenital syphilis in our institution was high. Factors associated with congenital syphilis were inadequate treatment of maternal syphilis and preterm birth. Improvement of prenatal care should be emphasized.
Genetic variability and stability analysis of chili in three environments
Authors: Inayah Yasmin Kamila  , Maharijaya Awang , Sobir  
Published: August 2023

Chili is an important vegetable crop consumed by most Indonesian people. Chili production is affected by the limited varieties and low adaptability to growing in different environments. This study aimed to identify the variability of 22 chili pepper on morphology, the genotype x environment interaction, and the stability of 10 chili pepper genotypes in 3 different environments. The study was conducted from July 2020 to February 2022 in Sleman DIY, Bogor, and Blitar. The experimental design used a single-factor randomized complete block design, each consisting of three replicates. The genotypes evaluated were HCR 17-003, HCR 17-004, HCR 17-007, HCR 17-008, HCR17-012, HCR 17-013, HCR 17-014, HCR 17-017, F7-1, F7-2, F7-3, Ca011, Ca013, Ca020, Ca021, Cf002, Cf005, Cf007, Cf010, Cf015, Bonita, and Loblita. Ten genotypes were evaluated in stability analysis, i.e., PKHT A, PKHT B, Bara, Genie, Centil, PKHT C, PKHT D, Bonita, Sona, and Tunduk. The biplot analysis for genetic diversity study showed a total diversity was 40.5% for the two main components. The genotype x environment interaction had a significant effect on productivity. PKHT C and Sona were identified as stable based on the Francis-Kannenberg method. PKHT C, Sona, PKHT B, and Bonita were stable based on the Wricke method. PKHT A and Bonita were stable based on Finlay-Wilkilson methods. PKHT B, PKHT C, Sona, and Bonita were identified as stable based on the AMMI method. The genotype which is stable based on all stability methods was PKHT C.
Keywords: AMMI; GxE interaction; parametric stability; variety.
MRI assessment of cervical spinal cord cross-sectional area in patients with multiple sclerosis
Authors: Al-Tameemi Haider N. , Hassoun Hayder K. , Mohammed Israa Q. , Allebban Zuhair 
Published: August 2023

Objectives:
Spinal cord abnormalities including cervical cord atrophy are common in multiple sclerosis (MS). This study aimed to assess the cervical spinal cord cross-sectional area (CSA) using magnetic resonance imaging (MRI) in MS patients.

Materials and Methods:
Sixty participants were enrolled in this study (16 male and 44 female), 30 patients with MS, diagnosed according to the revised McDonald criteria, and 30 apparently healthy individuals as the control group. CSA of the spinal cord was measured on axial T2-weighted images of the cervical MRI studies from C2 to C7 vertebral levels.

Results:
There was a significant difference between MS patients and the control group in mean CSA at a different level. The mean CSA at C2, in MS cases, was significantly lower than controls (67.7 ± 9.4 mm2 vs. 81.3 ± 4.6 mm2). Similarly, the mean CSA at C7 (64.4 ± 9.9 mm2) and average C2–7 (68 ± 9.1 mm2) of MS cases were significantly lower than the control. There was a strong inverse correlation between mean cervical cord CSA and duration of the disease and disability score. The reduction in cervical cord CSA was more prominent in patients with secondary progressive MS. There was no significant difference regarding age, gender, type of treatment, or the number of cervical cord lesions.

Conclusion:
The mean CSA was significantly lower in patients with MS than in the control group and was lesser in progressive types. Patients with a longer duration of MS and a high disability score tend to have smaller CSA.
Моделювання тренувань силової спрямованості для вдосконалення процесу ударної підготовки в хортингу
Authors: Fedorov Stanislav , Pantik Vasyl 
Published: August 2023

Мета роботи – виявити перспективність використання ефективних для силових видів спорту основних видів моделей тренувальних занять для підвищення рівня спеціальної ударної підготовки спортсменів із хор- тингу. Методи. Контингент обстежених складався із 60 спортсменів. Для кожної з трьох створених груп запропоновано окрему модель занять. Відмінність між моделями тренувань полягала у використанні різного варіанта поєднання вправ на тренажерах чи з вільною вагою обтяжень. При цьому використовувалася різна послідовність виконання базових й ізолюючих вправ. Контроль за змінами показників ударної підготовки (кількість влучно виконаних ударів ногами за 15 с із максимальною силою) відбувався на початку дослідження та протягом наступних трьох місяців із періодичністю в 30 днів. Результати. Установлено, що за три місяці досліджень найбільше підвищення рівня ударної підготовки на 28,8 % виявлено під час контрольної вправи
«кількість влучних прямих ударів коліном задньої ноги з однобічної бойової з максимальною силою за 15 с» у спортсменів другої групи. Відсутність кількісних змін досліджуваних показників простежено лише в спорт- сменів першої групи під час виконання таких вправ, як удар ногою знизу підйомом ступні в голову, короткий задній удар ногою. У спортсменів третьої групи, які використовували комбіновану модель тренувань, у порів- нянні з представниками інших груп, досліджувані показники підвищились у середньому на 11,2 % у зіставленні з вихідними даними. Висновки. Модель силової спрямованості, в основі якої використовуються комплекси вправ зі штангою та гантелями в умовах анаеробно-алактатного режиму енергозабезпечення та навантаженнями 85 % від 1RМ, згідно з результатами проведеного дослідження, є найбільш ефективною.