bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding tailoring to support the implementation of evidence-based interventions in healthcare: The CUSTOMISE research programme protocol
Authors: McHugh Sheena M , Riordan Fiona , Kerins Claire , Curran Geoff , Lewis Cara C , Presseau Justin , Wolfenden Luke , Powell Byron J 
Published: January 2023

Although there are effective evidence-based interventions (EBIs) to prevent, treat and coordinate care for chronic conditions they may not be adopted widely and when adopted, implementation challenges can limit their impact. Implementation strategies are “methods or techniques used to enhance the adoption, implementation, and sustainment of a clinical program or practice”. There is some evidence to suggest that to be more effective, strategies should be tailored; that is, selected and designed to address specific determinants which may influence implementation in a given context. Despite the growing popularity of tailoring the concept is ill-defined, and the way in which tailoring is applied can vary across studies or lack detail when reported. There has been less focus on the part of tailoring where stakeholders prioritise determinants and select strategies, and the way in which theory, evidence and stakeholders’ perspectives should be combined to make decisions during the process. Typically, tailoring is evaluated based on the effectiveness of the tailored strategy, we do not have a clear sense of the mechanisms through which tailoring works, or how to measure the “success” of the tailoring process. We lack an understanding of how stakeholders can be involved effectively in tailoring and the influence of different approaches on the outcome of tailoring. Our research programme, CUSTOMISE (Comparing and Understanding Tailoring Methods for Implementation Strategies in healthcare) will address some of these outstanding questions and generate evidence on the feasibility, acceptability, and efficiency of different tailoring approaches, and build capacity in implementation science in Ireland, developing and delivering training and supports for, and network of, researchers and implementation practitioners. The evidence generated across the studies conducted as part of CUSTOMISE will bring greater clarity, consistency, coherence, and transparency to tailoring, a key process in implementation science.
Possible transgenerational associations between grandparents’ childhood exposures and religious belief in their granddaughters: a longitudinal cohort study
Authors: Golding Jean , Gregory Steven , Northstone Kate , Pembrey Marcus , Ellis Genette , Watkins Sarah , Iles-Caven Yasmin , Suderman Matthew 
Published: January 2023

Background: Research in non-genetic inheritance indicates that grandparents’ smoking habits and their childhood experiences of trauma can influence the physical and psychological attributes of their grandchildren. This was particularly apparent for outcomes such as autism and obesity where the population prevalence changed over time. Other factors which have changed temporally include religious and spiritual beliefs (RSBs) which have been declining in Western populations. Methods: We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) to explore whether grandparental exposures were associated with the religious and/or spiritual beliefs of their grandchildren as measured with a positive response to the question “Do you believe in God or some divine power?” . In line with other inter/trans-generational human studies we hypothesised that: (H1) grandparents’ childhood exposures to cigarette smoking (whether in utero or by active smoking) and/or exposure to traumatic events during childhood will be associated with their grandchild’s RSB; (H2) associations will differ between maternal and paternal lines of inheritance; (H3) relationships will vary with age at grandparental exposure, and (H4) associations will differ between grandsons and granddaughters. Results: We found significant associations between the grandchild’s RSB and both the grandparents’ smoking and their childhood trauma histories (H1 supported). These associations were mainly found down the maternal line (H2 possibly supported) and results varied with age of exposure of the grandparents; being strongest for in utero exposure of cigarette smoke and for pre-puberty exposure of traumatic events (H3 supported), and that granddaughters were more affected than grandsons (H4 supported). Conclusions: We hope that these results will motivate collection of similar data to further evaluate these questions in other populations, including a possible role for biological mechanisms.
Zakopiańskie wczasowiczki w „Pożegnaniu jesieni”. Bohaterki Witkacego wobec typologii kobiet w literaturze o Tatrach
Authors: Pigoń Anna 
Published: January 2023

Kobiety opisywane w literaturze o Tatrach dzielą się na kilka wyraźnych grup zależnych od ich stosunku do przestrzeni. Jedną z nich są gościnie, a w jej ramach można wyróżnić wczasowiczki, czyli kobiety przebywające pod Tatrami w celach wypoczynkowych, niebudujące głębszej relacji z górskimi szczytami czy góralskimi realiami.W tę typologię wpisują się bohaterki ukazane przez Witkacego w powieści Pożegnanie jesieni (1925). Jej fabuła oraz bohaterowie nawiązują do doświadczeń autora. Hela Bertz i Zosia Osłabędzka funkcjonują w owym międzywojennym dziele na zasadzie opozycji. Pierwsza reprezentuje bowiem aktywną seksualność, druga bierność, która doprowadza ją do samobójczej śmierci.W artykule opisano typologię kobiet obecnych w literaturze o Tatrach, która następnie została odniesiona do bohaterek powieści Witkacego.
Wpływ rewolucji cyfrowej na międzynarodowe zasady podziału praw do opodatkowania
Authors: Morawska Kamila 
Published: January 2023

Przedmiotem artykułu są przede wszystkim działania podejmowane przez OECD w celu rozwiązania problemów podatkowych wynikających z rozpowszechniania się nowych modeli biznesowych gospodarki cyfrowej, w tym w szczególności koncepcję znaczącej obecności gospodarczej oraz tzw. rozwiązanie dwufilarowe. Następnie przedstawiono propozycje wysuwane przez autorów publikacji z zakresu międzynarodowego prawa podatkowego, a końcowo zostały sformułowane postulaty de lege ferenda dotyczące kierunku i zakresu zmian zasad opodatkowania przedsiębiorstw z branży cyfrowej.
Traducción de la sentencia de la Corte Internacional de Justicia (cij) relativa a la Delimitación marítima en el océano Índico (Somalia c. Kenia), decisión proferida el 12 de octubre de 2021
Authors: Abello-Galvis Ricardo , Arévalo-Ramírez Walter , Villamizar-Lamus Fernando , Tamayo-Álvarez Rafael 
Published: January 2023

A continuación, se presenta una traducción no oficial al español del texto de la sentencia de la cij relativa a la Delimitación marítima en el océano Índico (Somalia c. Kenia), cuya decisión fue proferida el 12 de octubre de 2021. El texto original de la sentencia puede ser consultado en la página web de la cij. La presente traducción es exclusivamente para fines de divulgación. No existe una versión oficial en español de las sentencias de la cij, estas se emiten solo en sus idiomas oficiales: francés e inglés, según el artículo 39-1 del Estatuto. Además, de acuerdo con lo ordenado en el párrafo 2 del mismo artículo, en cada sentencia la cij determina cuál es el idioma en el cual hace fe. En el presente caso fue el inglés. Al final de la traducción de la sentencia de fondo se incluyó también la traducción del resumen de las declaraciones, opiniones separadas y opiniones disidentes que los jueces adicionaron a la decisión.
All-fiber saturable absorber based on slightly tapered graded index multimode fiber for conventional and bound soliton generation
Authors: Wang Sanfei , Wang D. N. , Xu Ben 
Published: January 2023

A slightly tapered graded index multimode fiber (GIMF) is demonstrated
as the saturable absorber (SA) for a conventional soliton and tightly
bound soliton generation. The SA device is simply a GIMF spliced with
single-mode fiber (SMF) at its two ends. The waist diameter of the
slightly tapered fiber is

∼

23.8

µ

m

, located at one of the splicing
points of SMF and GIMF. The mode-locked output of conventional
solitons and tightly bound solitons can be obtained in a ring fiber
laser based on such a SA. The central wavelength of the output
conventional solitons is 1563.5 nm, and the pulse width is as
short as 473 fs at the fundamental frequency of
19.53 MHz. The central wavelength of the tightly bound solitons
is 1563.5 nm, with a pulse width of 636 fs and a
separation of 1.89 ps. The device is featured with a simple and
robust structure and stable operation capability and can effectively
overcome the difficulty in requirement of precise control of the GIMF
length, which make it attractive in ultrafast lasers and optical fiber
communication systems.
Sensitivity enhanced vector accelerometer based on FBG-FP inscribed on multicore fiber
Authors: Wang Jiaojiao , Chen Fengyi , Zhou Rui , Wang Ruohui , Qiao Xueguang 
Published: January 2023

We propose and fabricate a high-sensitivity vector vibration accelerometer with a multicore fiber Bragg grating Fabry–Perot (FBG-FP) structure. The acceleration sensitivities of the FBG and FBG-FP are 0.15 and 1.26 V/g, respectively. After packaging, the acceleration sensitivity of the FBG-FP is further improved to 6.89 V/g, which is 45.9 times higher than that of the FBG. The resonant frequency of the accelerometer increases from 30 to 86 Hz. Both the sensitivity and resonant frequency of the accelerometer are improved. Owing to the asymmetry of the outer core of the multicore fiber, high-sensitivity two-dimensional vector acceleration sensing can be realized.
Awareness, understanding, and interest in personalized medicine: A cross-sectional survey study of college students
Authors: Xu Yingke , Wu Qing 
Published: January 2023

Introduction
Personalized Medicine (PM) holds great potential in healthcare. A few existing surveys have investigated awareness, understanding, and interest regarding PM in the general public; however, studies investigating college students’ opinions about PM are lacking. This study aimed to evaluate the college student’s awareness, understanding, and interest in PM, and their opinion was also analyzed by their gender and major.

Methods
The study samples were undergraduate students enrolled at the University of Nevada, Las Vegas (UNLV). A web-based survey with 42 questions was emailed to all UNLV undergraduate students. Overall survey results were analyzed by gender and each student’s major. A chi-square test evaluated the significant association between responses to questions with regard to gender or major.

Results
Among the participants, 1225 students completed the survey. This survey found that most college students had a neutral attitude to PM and were not entirely familiar with this field. For example, most students (57.6%) had a “neutral” attitude toward PM. In addition, 77.6% of students never received any personal genetic testing. More than 80% of students thought “interests” was the most important factor in using PM, and 50% of respondents chose “somewhat likely” to the recommendation about PM from the doctor. Also of importance was the finding that a significant association between the most important factor of using PM and gender was observed (p = 0.04), and the associations between a student’s major affected his or her reaction to PM, how well informed she or he was about PM, his or her attitude toward a doctor’s recommendation about using PM were all significant (all participant’s p<0.004).

Conclusion
UNLV undergraduate students had a neutral attitude to PM and were not entirely familiar with this field.
Physical inactivity by tail suspension alters markers of metabolism, structure, and autophagy of the mouse heart
Authors: Rojo‐García Ana Victoria , Vanmunster Mathias , Pacolet Alexander , Suhr Frank 
Published: January 2023

AbstractSedentary behavior has become ingrained in our society and has been linked to cardiovascular diseases. Physical inactivity is the main characteristic of sedentary behavior. However, its impact on cardiovascular disease is not clear. Therefore, we investigated the effect of physical inactivity in an established mouse model on gene clusters associated with cardiac fibrosis, electrophysiology, cell regeneration, and tissue degradation/turnover. We investigated a sedentary group (CTR, n = 10) versus a tail suspension group (TS, n = 11) that caused hindlimb unloading and consequently physical inactivity. Through histological, protein content, and transcript analysis approaches, we found that cardiac fibrosis‐related genes partly change, with significant TS‐associated increases in Tgfb1, but without changes in Col1a1 and Fn1. These changes are not translated into fibrosis at tissue level. We further detected TS‐mediated increases in protein degradation‐ (Trim63, p < 0.001; Fbxo32, p = 0.0947 as well as in biosynthesis‐related [P70s6kb1, p < 0.01]). Corroborating these results, we found increased expression of autophagy markers such as Atg7 (p < 0.01) and ULK1 (p < 0.05). Two cardiomyocyte regeneration‐ and sarcomerogenesis‐related genes, Yap (p = 0.0535) and Srf (p < 0.001), increased upon TS compared to CTR conditions. Finally, we found significant upregulation of Gja1 (p < 0.05) and a significant downregulation of Aqp1 (p < 0.05). Our data demonstrate that merely 2 weeks of reduced physical activity induce changes in genes associated with cardiac structure and electrophysiology. Hence, these data should find the basis for novel research directed to evaluate the interplay of cardiac functioning and physical inactivity.
Voluntary activation of the diaphragm after inspiratory pressure threshold loading
Authors: Ramsook Andrew H. , Schaeffer Michele R. , Mitchell Reid A. , Dhillon Satvir S. , Milne Kathryn M. , Ferguson Olivia N. , Puyat Joseph H. , Koehle Michael S. , Sheel A. William , Guenette Jordan A. 
Published: January 2023

AbstractAfter a bout of isolated inspiratory work, such as inspiratory pressure threshold loading (IPTL), the human diaphragm can exhibit a reversible loss in contractile function, as evidenced by a decrease in transdiaphragmatic twitch pressure (PDI,TW). Whether or not diaphragm fatigability after IPTL is affected by neural mechanisms, measured through voluntary activation of the diaphragm (D‐VA) in addition to contractile mechanisms, is unknown. It is also unknown if changes in D‐VA are similar between sexes given observed differences in diaphragm fatigability between males and females. We sought to determine whether D‐VA decreases after IPTL and whether this was different between sexes. Healthy females (n = 11) and males (n = 10) completed an IPTL task with an inspired duty cycle of 0.7 and targeting an intensity of 60% maximal transdiaphragmatic pressure until task failure. PDI,TW and D‐VA were measured using cervical magnetic stimulation of the phrenic nerves in combination with maximal inspiratory pressure maneuvers. At task failure, PDI,TW decreased to a lesser degree in females vs. males (87 ± 15 vs. 73 ± 12% baseline, respectively, p = 0.016). D‐VA decreased after IPTL but was not different between females and males (91 ± 8 vs. 88 ± 10% baseline, respectively, p = 0.432). When all participants were pooled together, the decrease in PDI,TW correlated with both the total cumulative diaphragm pressure generation (R2 = 0.43; p = 0.021) and the time to task failure (TTF, R2 = 0.40; p = 0.30) whereas the decrease in D‐VA correlated only with TTF (R2 = 0.24; p = 0.041). Our results suggest that neural mechanisms can contribute to diaphragm fatigability, and this contribution is similar between females and males following IPTL.
Fixed-point results for convex orbital operators
Authors: Popescu Ovidiu 
Published: January 2023

Abstract
The aim of this article is to introduce a new type of operator similar to those of A. Petruşel and G. Petruşel type (Fixed point results for decreasing convex orbital operators, J. Fixed Point Theory Appl. 23 (2021), no. 35) and prove some fixed-point theorems which generalize and complement several results in the theory of nonlinear operators.
Improved dimensional stability and mechanical properties of rubberwood via modification with maleated lignin and densification
Authors: Gao Zhizun , Wang Wenjing , Yu Fanjun , Wang Yonggui , Xiao Zefang , Xie Yanjun 
Published: January 2023

Abstract
Rubberwood was modified using a two-step process involving impregnation with maleated lignin (ML) followed by densification. The effects of ML modification and densification on the physical and mechanical properties of modified wood were studied. The successful preparation of ML was confirmed using Fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy. In addition, scanning electron microscopy was used to characterize the densified rubberwood structure, which featured fully compressed cell walls and cell lumina filled with ML. The rubberwood modification resulted in a more uniform structure and increased density compared to untreated wood. Further, water immersion and moisture absorption experiments revealed thickness swelling of only 27.7% and 20.9%, a reduction of nearly 76% and 55%, respectively, compared to the densified wood that was only impregnated with water. The ML modification can alleviate the embrittlement of wood caused by densification. The modulus of rupture and modulus of elasticity of ML-treated and densified wood improved by nearly 54% and 200%, respectively, compared to untreated wood. Therefore, the synergistic treatment strategy can contribute to the high-value utilization of low-quality rubberwood.
Activation of PPARα Exhibits Therapeutic Efficacy in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis
Authors: Jana Malabendu , Dutta Debashis , Poddar Jit , Pahan Kalipada 
Published: January 2023

Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal inherited neurodegenerative disease of children that occurs because of defective function of the lysosomal membrane glycoprotein CLN3. JNCL features glial activation and accumulation of autofluorescent storage material containing subunit c of mitochondrial ATP synthase (SCMAS), ultimately resulting into neuronal loss. Until now, no effective therapy is available for JNCL. This study underlines the possible therapeutic importance of gemfibrozil, an activator of peroxisome proliferator-activated receptor α (PPARα) and a lipid-lowering drug approved by the Food and Drug Administration in an animal model of JNCL. Oral gemfibrozil treatment reduced microglial and astroglial activation, attenuated neuroinflammation, restored the level of transcription factor EB (TFEB; the master regulator of lysosomal biogenesis), and decreased the accumulation of storage material SCMAS in somatosensory barrel field (SBF) cortex of Cln3Δex7/8(Cln3ΔJNCL) mice of both sexes. Accordingly, gemfibrozil treatment also improved locomotor activities of Cln3ΔJNCL mice. While investigating the mechanism, we found marked loss of PPARα in the SBF cortex of Cln3ΔJNCL mice, which increased after gemfibrozil treatment. Oral gemfibrozil also stimulated the recruitment of PPARα to theTfebgene promoterin vivoin the SBF cortex of Cln3ΔJNCL mice, indicating increased transcription ofTfebin the CNS by gemfibrozil treatment via PPARα. Moreover, disease pathologies aggravated in Cln3ΔJNCL mice lacking PPARα (Cln3ΔJNCLΔPPARα) and gemfibrozil remained unable to decrease SCMAS accumulation, reduce glial activation, and improve locomotor performance of Cln3ΔJNCLΔPPARαmice. These results suggest that activation of PPARα may be beneficial for JNCL and that gemfibrozil may be repurposed for the treatment of this incurable disease.SIGNIFICANCE STATEMENTDespite intense investigations, no effective therapy is available for JNCL, an incurable inherited lysosomal storage disorder. Here, we delineate that oral administration of gemfibrozil, a lipid-lowering drug, decreases glial inflammation, normalizes and/or upregulates TFEB, and reduces accumulation of autofluorescent storage material in SBF cortex to improve locomotor activities in Cln3Δex7/8(Cln3ΔJNCL) mice. Aggravation of disease pathology in Cln3ΔJNCL mice lacking PPARα (Cln3ΔJNCLΔPPARα) and inability of gemfibrozil to decrease SCMAS accumulation, reduce glial activation, and improve locomotor performance of Cln3ΔJNCLΔPPARαmice delineates an important role of PPARα in this process. These studies highlight a new property of gemfibrozil and indicate its possible therapeutic use in JNCL patients.
Tratamiento con bromuro de piridogstimina en un canino con dificultad para vaciar la vejiga en canino positivo para miastenia gravis adquirida
Authors: Mundo Silvia , Montoro Andrea , Kim Angélica , Ruidiaz Viviana , Suraniti Adriana 
Published: January 2023

Introducción: La miastenia gravis adquirida (MGA) es una enfermedad inmunomediada, que presenta disminución en el número o funcionalidad de receptores de la acetilcolina a nivel nicotínico. Esto conlleva que la contracción muscular sea menos efectiva. La manifestación clínica más común es la debilidad episódica que aumenta con el ejercicio y mejora con el reposo. Otros signos clínicos son regurgitaciones y cambios de voz. El propósito de este reporte es describir un canino hembra con disuria sin estranguria que fue llevado a consulta al Hospital Escuela de Medicina Veterinaria de la Universidad de Buenos Aires.
Metodología: se realizaron análisis de sangre y orina, urocultivos, radiografías de columna, ecografía abdominal, electromiografía (EMG) de esfínter anal y de estimulación repetitiva, se midieron anticuerpos contra receptores de la acetilcolina (ACRA).
Resultados: fueron normales los análisis de sangre, urianálisis, radiografías de columna y ecografía de abdomen. Los urocultivos fueron negativos. La EMG del esfínter anal fue conservada. La EMG estimulación repetitiva fue compatible con MGA. El paciente resultó ACRA positivo y su respuesta al tratamiento con bromuro de piridostigmina (BRP) fue favorable.
Conclusiones: incluir dentro del diagnóstico deferencial a la MGA en pacientes caninos con disuria.
A Bayesian Lasso Logistic Regression Model for Predicting the Probability of Regional Seismic Phase Observation UsingSnin the Middle East and East Asia as Examples
Authors: Hui Hongjun , Nandy Saikat , Holan Scott H. , Pan Jingjing , Li Duyi , Sandvol Eric A. 
Published: January 2023

ABSTRACTHigh-frequency seismic wave blockage is often the result of strong attenuation, and the regional phase Sn is particularly prone to blockage in comparison with any of the other regional phases including Lg. As widespread blockage can lead to difficulty in the estimation of source parameters or path attenuation, accurate characterization of efficient regional wave propagation is necessary. We have applied two approaches to map Sn phase blockage: (1) the relatively standardized efficiency tomography and (2) a newly developed Bayesian logistic regression model that is able to predict the likelihood (probability) of phase blockage. As a byproduct of our Bayesian approach, we obtain measures of uncertainty for the probability of blockage. We applied both our methods on simulated efficiency data as well as real efficiency data obtained from earthquakes and stations from the middle east and eastern Asia. Our models successfully predict the probability of blockage zones with relatively high accuracy (&gt;75%). In addition, we observe both low probability of Sn blockage and efficient Sn propagation in tectonically stable continental lithosphere, such as the Arabian plate, the Mediterranean Sea, northeastern Iran, the Ordos plateau, and the Sichuan basin. Regions with a high probability of Sn blockage or inefficient Sn propagation zones are in the tectonically active areas, such as the Tibetan and Iranian plateaus. Our probability of blockage model can also be used to image the regions where SnQ models are likely to be biased due to blocked data.