bluuebunny/crossref_metadata_2025_split huggingface dataset:
The determinants of innovation performance: an income-based cross-country comparative analysis using the Global Innovation Index (GII)
Authors: Bate Adisu Fanta , Wachira Esther Wanjiru , Danka Sándor 
Published: March 2023

AbstractDespite the dearth of research on innovation, the key determinants of innovation performance still need to be clarified. Besides, a comparative analysis of the determinants of innovation performance across countries at different income levels has yet to be found. This study, therefore, aims to bridge this research gap by considering the innovation performance of 63 countries. Participating countries were purposefully selected from the Global Innovation Index (GII) dataset. Multistage and multimodal analyses were conducted, including multiple linear regressions, hierarchical regression, and ANOVA, to examine the variation in innovation performance and pinpoint critical determinants in each category of countries. The result reveals that human capital, research, infrastructure, and business sophistication are the key pillars determining countries’ innovation performance. In a variable-level analysis, innovation linkage and knowledge absorption (both of business sophistication), research and development (R&D), and infrastructure (inculcating both physical and digital) are the best predicting variables. The shortage of human capital to promote R&D is the biggest bottleneck hampering innovation in the lower-middle-income category. Also, both human capital for R&D activities and innovation linkage equally affect the upper-middle-income, and the latter one, innovation linkage, remains the main challenge even for the high-income category. The study implies that innovation performance predicts a country’s economic growth. The level of innovation performance and the determinants of innovation vary per the countries’ income levels. Accordingly, countries and firms in various income categories should prioritize tackling their respective bottlenecks hindering innovation performance in their policy directions. The study claims to have extended the horizon of understanding determinants of innovation across countries and revealed the most crucial factors in each category of countries. Further empirical comparative research can be done by incorporating an informal institution, national culture, as an additional determinant and specifying sectors across income categories.
CONHECIMENTO PODEROSO E IDEIAS FUNDAMENTAIS: UMA PROPOSTA DE CURRÍCULO EM ESPIRAL PARA A FÍSICA ESCOLAR
Authors: Gomes de Lima Luís 
Published: March 2023

O presente trabalho investiga a proposição de um currículo de física em espiral baseado no conhecimento poderoso e nas ideias fundamentais. Busca-se a construção de um currículo de física que garanta o acesso dos estudantes, especialmente das escolas públicas, ao conhecimento clássico, ao saber sistematizado, para que possam, de fato, se emancipar por meio do chamado conhecimento poderoso. Nessa proposta, rejeitamos a extinção da disciplina de física, e o esvaziamento curricular na atual Base Nacional Comum Curricular e no Novo Ensino Médio. A investigação aponta para a possibilidade de um currículo de física amplo, que supera o pragmatismo e a diminuição dos saberes da física nas propostas curriculares atuais. Como resultados, o currículo de física em espiral, formado por meio das ideias fundamentais, promove o conhecimento poderoso e potencializa a compreensão dos estudantes sobre novos saberes.
The effect of menopause on cardiovascular risk factors according to body mass index in middle-aged Korean women
Authors: Song Do Kyeong , Hong Young Sun , Sung Yeon-Ah , Lee Hyejin 
Published: March 2023

BackgroundMenopausal status and obesity are associated with an increased risk for cardiovascular diseases. However, there are few studies on the effect of menopause on cardiovascular risk factors according to the degree of obesity during the menopausal transition. We aimed to evaluate the effect of menopause on cardiovascular risk factors according to body mass index (BMI) in middle-aged Korean women.MethodsWe analyzed 361 postmenopausal women and 758 premenopausal women (age: 45–55 years) without diabetes mellitus, hypertension, or dyslipidemia, using a cohort database released by the Korean National Health and Nutrition Examination Survey 2016–2018. Subjects were divided into two groups based on BMI. Women who underwent a hysterectomy or were pregnant were excluded from this study. Differences between groups adjusted for age and BMI were assessed.ResultsPostmenopausal women (52 ± 2 years) were older than premenopausal women (48 ± 2 years), and BMI did not differ between the two groups (22.8 ± 2.9 vs. 23.0 ± 3.1 kg/m2). After adjustment for age and BMI in total and non-obese subjects (not obese subjects), postmenopausal women exhibited higher hemoglobin A1c and total cholesterol levels than premenopausal women. Subgroup analysis for 138 postmenopausal and 138 age- and BMI-matched premenopausal women showed that postmenopausal women had higher total cholesterol levels than premenopausal women with marginal significance (201 ± 25 vs. 196 ± 27 mg/dL).ConclusionMenopausal status was associated with increased glucose and cholesterol levels independent of age and BMI in middle-aged Korean women. Menopausal status showed a significant relationship with increased total cholesterol levels even after adjusting for age and BMI in non-obese women but not obese women. Therefore, intensive monitoring and treating of lipid status is necessary to prevent cardiovascular events during the menopausal transition, especially in non-obese subjects.
Long-term effects of early/late-onset visual deprivation on macular and retinal nerve fibers layer structure: A pilot study
Authors: Magli Adriano , Esposito Veneruso Paolo , Rinaldi Michele , Caputo Roberto , Tranfa Fausto , Costagliola Ciro 
Published: March 2023

Background/aims
Tomographic analysis of macular and peripapillary retinal nerve fibers layer (RNFL) thickness in patients with history of congenital (CC) and developmental cataract (DC).

Methods
Analysis of macular and RNFL thickness using a spectral-domain optical coherence tomography was performed. Retinal layers thickness was measured using the internal segmentation software. Measurements of affected (unilateral and bilateral), contralateral eyes and control eyes were compared.

Results
Patients with history of CC or DC (n = 13 and 11 respectively) and 35 healthy control subjects were enrolled. Thicker inner and outer nuclear layers (INL, ONL) and thicker ONL were found when CC and DC group when compared to controls respectively. Bilateral CC showed the most relevant differences. Slight thickening of CC inner retinal layers were found when compared to DC. Increased superonasal RNFL thickness was found in CC group when compared to DC and controls. Thickening of RNFL of contralateral unaffected eyes of unilateral CC were found when compared to controls.

Conclusion
Significant macular and RNFL thickness changes between CC, DC patients and controls that partially involve also contralateral unaffected eyes of unilateral congenital cataract were found. CC and DC groups show significant differences only in inner retinal layers thickness. Our data suggest that early visual deprivation may influence retinal arrangements occurring during development involving predominantly the outer nuclear layer and para/perifoveal inner retinal layers, and confirm that early treatment of CC allow to achieve better long-term visual outcome. Moreover functional and structural data support the hypothesis that unilateral amblyopia is not exclusively an unilateral issue.
Ongoing increasing trends in central precocious puberty incidence among Korean boys and girls from 2008 to 2020
Authors: Kang Sinyoung , Park Mi Jung , Kim Jung Min , Yuk Jin-Sung , Kim Shin-Hye 
Published: March 2023

Background
Over the last few decades, there has been growing evidence of earlier onset and progression of puberty worldwide. This population-based longitudinal cohort study aimed to analyze the change in the annual incidence rate of central precocious puberty (CPP) among Korean children over the most recent decade, using the national registry data.

Method
The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) and insurance claims for gonadotropin-releasing hormone agonist (GnRHa) treatment were used to identify CPP patients who were using the Korean Health Insurance Review & Assessment Service (HIRA) database between 2008 and 2020. Patients who began GnRHa therapy before the age of 9 and 10 for girls and boys, respectively, were included in the study.

Results
A total of 6,906 boys and 126,377 girls were diagnosed with CPP between 2008 and 2020. The annual incidence of CPP increased by 83.3 times in boys (from 1.2 to 100 per 100,000 persons) and by 15.9 times in girls (from 88.9 to 1414.7 per 100,000 persons). The age-specific annual incidence of CPP increased remarkably more in older children than in younger ones; the 2020 CPP incidence among 9-year-old boys and 8-year-old girls reached 705.2 and 7,967.3 per 100,000 persons, respectively. The annual prevalence of CPP in boys and girls increased from 2.7 to 206.5 (76.5 times) and from 141.8 to 3439.9 (24.3 times) per 100,000 persons, respectively.

Conclusion
Based on GnRHa treatment insurance claims, our study suggests that the annual incidence of CPP has substantially increased in Korea during the past 13 years. These findings highlight the importance of meticulous judgment by doctors in determining GnRHa treatment.
The effect of tablet tilt angles and time on posture, muscle activity, and discomfort at the neck and shoulder in healthy young adults
Authors: Rungkitlertsakul Siriyaphorn , Bhuanantanondh Petcharatana , Buchholz Bryan 
Published: March 2023

Background
Although young adults regularly perform tablet writing, biomechanics during the tablet writing with different tilt angles has not been studied. The objective of this study was to compare posture, muscle activity, and discomfort at the neck and shoulder between tablet writing with 0° (horizontal) and 30° tablet tilt angles over 40 minutes in healthy young adults.

Methods
Twenty participants wrote continuously for 40 minutes on a tablet with both tilt angles in a randomized order. Between conditions, there was a 5-minute activity break. Differences in neck and shoulder posture, muscle activity, and discomfort between both tablet tilt angles and changes in the outcomes every 10 minutes over 40 minutes were investigated.

Results
With the tilted tablet, there were lower neck flexion (Z = -4.637, P<0.001), lower shoulder extension (Z = -3.734, P<0.001), and lower neck Visual Analogue Scale (VAS) (left; Z = -4.699, P<0.001 and right; Z = -3.874, P<0.001) as compared to the no tilt condition. However, the right upper trapezius muscle activity was higher in the tilted condition as compared to the no tilt one.
Over 40 minutes, the neck VAS (left; χ2(4) = 30.235, P<0.001 and right; χ2(4) = 32.560, P<0.001) and heart rate variability (χ2(4) = 12.906, P = 0.012) showed notable increases after 20 minutes compared to baseline.

Conclusion
In conclusion, adjusting the tablet tilt to 30° and limiting time spent to 20 minutes are recommended for young adults during the tablet writing to prevent neck problems.
A comprehensive study of Ecuadorian adult patients with a mild and moderate presentation of COViD-19
Authors: González-Andrade Fabricio , Carrero Yenddy 
Published: March 2023

Aim
To characterize non-hospitalized patients with mild and moderate clinical presentation.

Methods
We performed an epidemiological, observational, descriptive, and cross-sectional study carried out in Ecuador, with 1,447 participants between 18 and 66 years, non-hospitalized, with a molecular RT-PCR test for SARS-CoV2. We analyzed demographic characteristics according to sex, age group, clinical findings, behavior after diagnosis, family and social behavior, sequelae, clinical evolution, type of exposure, and personal history.

Results
The sample analyzed had a mean age of 37 years (95% CI 18–66), women 713 individuals (49.27%), men 733 individuals (50.66%). Age group distribution was 18–30 years, 524 individuals (36.29%), 31–45, 538 individuals (37.26), and more of 45 years, 382 individuals (26.46%). 1416 individuals were mestizos (97.99%). According to the province of residence from Pichincha were 1019 patients (70.52%), followed by Imbabura, 93 patients (6.44%), and the others 335 (23.15%) patients come from all over the country. In women, the most common findings were fever >38°C (54.40%), sputum (27.43%) and hypoxia (16.32%); HTN (5.75%) and hypercholesterolemia (3.69%). Men were more prevalent in all other findings. Comorbidities were more prevalent in all those over 45 years of age. COVID-19 antibodies test was positive in 416 patients (28.85%). Neuropsychiatric symptoms such as sleep disorders, generalized anxiety disorder, depressed mood, and chronic fatigue were more prevalent in men than women. Still, generalized anxiety disorder and chronic fatigue were more common in individuals of 31 to 45 years. 868 patients (60.07%) were in contact with a known infected person, 318 patients (22.02%) were health workers, and 782 patients (57.63%) were informed about work exposure. 545 patients (37.72%) were overweight, primarily women 310 (42.29%). 609 patients (42.65%) showed symptoms after the acute period, and 331 individuals (23.49%) reported some sequelae.

Conclusion
The epidemiological and clinical behavior of hospitalized and critical patients differs greatly from ambulatory or mild or moderate symptoms. It is essential to highlight those non-hospitalized patients constitute the predominant population of patients, hence the importance of adequate management that would directly affect the development of complicated forms and, consequently, the collapse of healthcare centers. It is vitally important to open more investigations that compare hospitalized and outpatient patients to have a clearer picture of the epidemic.
Hemosuccus Pancreaticus: Diagnostic Pitfalls of a Rare Condition
Authors: Busebee Bradley , AT Kurdi , BR Stultz , LN Sayegh , Coelho-Prabhu Nayantara 
Published: March 2023

ABSTRACT
The combination of cirrhosis and chronic pancreatitis is rare and poses increased risk of hemorrhage requiring close clinical monitoring. We present a patient with history of alcohol-associated cirrhosis and chronic pancreatitis who was admitted to the intensive care unit with clinical hemorrhage believed secondary to epistaxis. After initial delay, esophagogastroduodenoscopy ultimately found blood and clots evacuating through the ampulla consistent with hemosuccus pancreaticus confirmed with computed tomography angiography. The patient ultimately improved with coil and gel foam vascular embolization. This case highlights the dangers of early diagnostic closure and presents a rare finding of hemosuccus without pseudoaneurysm formation.
Redes neuronales aplicadas al control estadístico de procesos con cartas de control EWMA
Authors: Suárez Castro Ruth Milena , Ladino Vega Iván Darío 
Published: March 2023

Objetivo: Diseñar una red neuronal recurrente LSTM para predecir el valor promedio de la variable temperatura y evaluar así, la capacidad de la red para obtener valores similares a los cálculos del promedio móvil ponderado EWMA para mediciones individuales.
Metodología: Se obtuvieron 1768 registros de mediciones individuales de temperatura realizadas por un sensor, en el conjunto de datos denominado: Gas sensors for home activity monitoring data set. Los datos de temperatura se representaron en una carta de control de promedios móviles ponderados exponenciales EWMA, a fin de obtener los valores de la media del proceso y de identificar que el proceso estuviera dentro del control estadístico. Posteriormente se entrenó una red neuronal LSTM a una muestra de entrenamiento de 1184 datos con algoritmo Backpropagation que permitiera obtener valores similares a EWMA, los cuales se validaron en una muestra de prueba de 584 datos de temperatura.
Resultados: El diseño de una red neuronal con una unidad en la puerta de entrada, 4 unidades en la puerta de olvido y 1 unidad en la puerta de salida entrenada con el algoritmo Backpropagation permitió calcular valores muy cercanos a los representados en la carta de control EWMA, con un MSE de 1.1405e-04.
Conclusiones: Las redes neuronales LSTM son una buena alternativa para el cálculo de valores EWMA, cuando se requiera hacer control estadístico de un proceso que genera gran cantidad de datos obtenidos de mediciones y no se cuente con un software para procesarlos.
Financiamiento: Fundación universitaria Los Libertadores
PERBEDAAN POLA PEMBERIAN MP-ASI ANTARA ANAK BERAT BADAN KURANG DENGAN BERAT BADAN NORMAL USIA 6 – 12 BULAN DI WILAYAH KERJA PUSKESMAS GUNUNG PATI KOTA SEMARANG
Authors: Anjani Habibah Alim , Nuryanto Nuryanto , Wijayanti Hartanti Sandi , Purwanti Rachma 
Published: March 2023

Latar Belakang: Pola pemberian MPASI berpengaruh pada pertumbuhan bayi dan anak. Pemberian MPASI yang tidak tepat akan menyebabkan berat badan kurang pada bayi.Tujuan : Untuk menganalisis perbedaan pola pemberian MPASI antara bayi berat badan kurang dengan berat badan normal usia 6 – 12 bulan.Metode: Penelitian cross-sectional dilakukan di Kota Semarang. Subjek terdiri dari 28 subjek berat badan kurang dan 28 subjek berat badan normal yang diambil dengan metode purposive sampling. Variabel yang diteliti yaitu pola pemberian MPASI, tingkat kecukupan zat gizi, dan status gizi BB/U. Data karakterisik subjek dan pola pemberian MPASI meliputi waktu pemberian MPASI pertama, riwayat ASI eksklusif, riwayat ASI saat ini, jenis, frekuensi, porsi pemberian MPASI, dan responsive feeding didapatkan dari wawancara menggunakan kuesioner. Data tingkat kecukupan zat gizi didapatkan dari kuesioner food recall 3x24 jam. Berat badan kurang ditentukan dengan perhitungan Z-score BB/U -3 s/d <-2 SD, sedangkan berat badan normal ditentukan dengan Z-score BB/U -2 s/d +2 SD. Analisis bivariat menggunakan uji Chi-Square, Independent T-Test dan Mann Whitney-Test.Hasil: Terdapat perbedaan porsi pemberian MPASI, tingkat kecukupan energi, karbohidrat, dan lemak pada kelompok bayi berat badan kurang dan normal (p=0,001; p=0,013; p=0,036; p=0,021). Tidak terdapat perbedaan tingkat kecukupan protein, riwayat ASI eksklusif, riwayat ASI saat ini, waktu pemberian MPASI pertama, jenis, frekuensi pemberian MPASI, dan responsive feeding pada kelompok bayi berat badan kurang dan normal (p>0,05). Simpulan: Terdapat perbedaan porsi MPASI, tingkat kecukupan energi, karbohidrat dan lemak antara bayi berat badan kurang dan berat badan normal usia 6-12 bulan. Tidak terdapat perbedaan riwayat ASI eksklusif, riwayat ASI saat ini, waktu pemberian MPASI pertama, jenis, frekuensi pemberian MPASI, responsive feeding, dan tingkat kecukupan protein antara bayi berat badan kurang dan berat badan normal usia 6-12 bulan.
Opisy podróży na Bliski Wschód i do Afryki Północnej z lat 1801–1919 w zbiorach Uniwersytetu im. Adama Mickiewicza w Poznaniu
Authors: Jakubowski Filip 
Published: March 2023

Artykuł dotyczy XIX-wiecznych opisów podróży na arabski Bliski Wschód i do Afryki Północnej, przechowywanych w zbiorach Uniwersytetu im. Adama Mickiewicza w Poznaniu. W większości znajdują się one w Bibliotece Uniwersyteckiej, część w bibliotekach wydziałowych. Kolekcja ta, choć nie powstała w sposób celowy, składa się z 250 tytułów w ośmiu językach, z czego dwie trzecie to pozycje niemieckojęzyczne. Najwięcej książek pochodzi z Kaiser Wilhelm Bibliothek w Poznaniu. Kolekcja odzwierciedla rozwój tego gatunku piśmiennictwa w Europie w XIX wieku i pokazuje jego różnorodność.
Paciente con insuficiencia suprarrenal por mutación de novo en el gen NR0B1
Authors: Bravo Nieto Daniel , García Fernández Alba S. , Diaz Troyano Noelia , Giralt Arnaiz Marina , Arias García Andrea , Fernández Álvarez Paula , Campos Martorell Ariadna , Ferrer Costa Roser , Clemente León María 
Published: March 2023

Resumen

Objetivos
La hipoplasia suprarrenal congénita ligada al cromosoma X es una enfermedad rara con base genética conocida, que se presenta con insuficiencia suprarrenal e hipogonadismo hipogonadotrófico y expresión clínica variable.

Caso clínico
Paciente varón, de 26 días, que ingresó con síntomas compatibles con insuficiencia suprarrenal, hiponatremia e hiperpotasemia, requiriendo sueroterapia con suplementos de NaCl y fludrocortisona, consiguiéndose estabilidad clínica. Se descartó la hiperplasia suprarrenal congénita tras la medición de 17-OH-progesterona. El resto de hormonas estaban dentro de los intervalos de referencia, salvo la hormona adrenocorticotrópica (ACTH), sensiblemente por encima, y la aldosterona, por debajo. En los siguientes análisis se estudiaron los ácidos grasos de cadena muy larga para descartar adrenoleucodistrofia, el gen CYP11B2 (aldosterona sintasa), y se realizó una RMN para descartar otras alteraciones morfológicas. Todas estas pruebas resultaron normales. Finalmente, tras detectar déficit de cortisol en una analítica, se realizó un estudio genético más amplio donde se describió una mutación en el gen NR0B1, estableciéndose el diagnóstico de hipoplasia suprarrenal congénita.

Conclusiones
La hipoplasia suprarrenal congénita es una enfermedad de diagnóstico complejo debido a la variabilidad en la expresión clínica y el grado de alteración de las pruebas de laboratorio, requiriéndose un seguimiento exhaustivo y la realización de pruebas genéticas para llegar al diagnóstico.
On completeness of weak eigenfunctions for multi-interval Sturm-Liouville equations with boundary-interface conditions
Authors: Olgar Hayati 
Published: March 2023

Abstract
The goal of this study is to analyse the eigenvalues and weak eigenfunctions of a new type of multi-interval Sturm-Liouville problem (MISLP) which differs from the standard Sturm-Liouville problems (SLPs) in that the Strum-Liouville equation is defined on a finite number of non-intersecting subintervals and the boundary conditions are set not only at the endpoints but also at finite number internal points of interaction. For the self-adjoint treatment of the considered MISLP, we introduced some self-adjoint linear operators in such a way that the considered multi-interval SLPs can be interpreted as operator-pencil equation. First, we defined a concept of weak solutions (eigenfunctions) for MISLPs with interface conditions at the common ends of the subintervals. Then, we found some important properties of eigenvalues and corresponding weak eigenfunctions. In particular, we proved that the spectrum is discrete and the system of weak eigenfunctions forms a Riesz basis in appropriate Hilbert space.