bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water security: a Geospatial Framework for urban water resilience
Authors: Jain Tholiya Jyoti , Chaudhary Navendu 
Published: July 2023

Abstract

Urban water issues impacting sustainable development can be analyzed, modeled, and mapped through cutting-edge geospatial technologies; however, the water sector in developing countries suffers various spatial data-related problems such as limited coverage, unreliable data, limited coordination, and sharing. Available spatial data are limited to the aggregate level (i.e., national, state, and district levels) and lack details to make informed policy decisions and allocations. Despite significant advancements in geospatial technologies, their application and integration at the policy and decision-making level are rare. The current research provides a broad GIS-centric framework for actionable science, which focuses on real context and facilitates geospatial maps and theoretical and practical knowledge to address various water issues. The study demonstrates the application of the proposed Geospatial Framework from technical and institutional perspectives in water-stressed zones in Pune city, showing where and how to solve problems and where proposed actions can most impact creating a sustainable water-secured future. The framework makes it possible for everyone to explore datasets that can provide a baseline for research, and analysis, contribute to the process, propose, and act on solutions, and take the benefits of the outcomes and policy recommendations.
Hybrid microalgae-activated sludge system for carbon-efficient wastewater treatment
Authors: Mohammed Kasim , Ahammad S. Z. , Sallis P. J. , Mota C. R. 
Published: July 2023

Abstract
Engineered microalgae-bacteria systems can play a key role in the realisation of energy-efficient carbon-neutral wastewater treatment technologies. An attempt was made to develop a hybrid microalgae-activated sludge (HMAS) system coupling carbon capture with domestic wastewater treatment. Photobioreactors internally illuminated with red light-emitting diodes (LEDs), and inoculated with mixed microbial culture, resulted in substantial savings in operational cost. System performance was evaluated at about 600 μmol/m2 s LED irradiance while treating synthetic municipal wastewater in a chemostat for about 2 months, containing about 250 mg/L soluble chemical oxygen demand (SCOD), 90 mg/L NH3-N and 10 mg/L orthophosphate. Carbon dioxide was supplied into the HMAS at 25 mL/min, 25% v/v. SCOD was efficiently removed from the wastewater (up to 70%) and bacterial oxygen requirement of &gt;2 mg/L was met through microalgal photosynthesis. The system demonstrated its potential in achieving carbon-efficient wastewater treatment.
Superación de la aporofobia desde la educación, compasión e instituciones en la ética de Adela Cortina
Authors: Fuentes Valdebenito Nicolás 
Published: July 2023

La inmigración es un fenómeno muy presente y esto ha producido consecuencias sociales en donde se ha rechaza al extranjero, es decir, de la xenofobia, pero Adela Cortina va más allá de eso y afirma que no es la xenofobia el sentimiento de rechazo al extranjero en general porque es al extranjero pobre al que se rechaza, por eso acuña el término aporofobia. Para esto en su ética propone la educación, compasión y respeto activo como respuestas éticas. Sin embargo, hay que ir a la profundidad del tema que es la superación de la pobreza, es por eso por lo que la creación de instituciones que vayan en esa línea es fundamental. Finalmente, una sociedad sin humillación sería un Reino de los Fines, donde todos valen como fines en sí mismos y no meramente como medios, a la vez una sociedad cosmopolita donde exista el derecho a la libre expresión, al desplazamiento y al derecho político a la participación (Cortina, 2022).
Red Seaweed-derived Compounds: A Desired Approach for Treating Cancer
Authors: Katiyar Shweta , Jin Xing-Hai , Yadav Dhananjay 
Published: July 2023

Abstract:
Cancer is a collection of diseases in which aberrant cells grow uncontrolled and invade surrounding
tissues. Cancer can be classified as carcinoma, sarcoma, leukemia, or lymphoma. The deadliest cancers are
lung, breast, colorectal, pancreatic, and prostate. Chemotherapy, surgery, and radiotherapy are the usual cancer
treatments. However, drug resistance poses a significant barrier to cancer treatment. Macroalgae are wellknown
producers of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory, and anti-cancer
properties. Red algae, in particular, are a prominent source of bioactive substances, such as polysaccharides,
phenolic compounds, lipids, sterols, alkaloids, and terpenoids. Therefore, molecules from marine resources
could be an appealing way to identify new cancer treatment alternatives. This study aimed to provide a brief
overview of what is currently known regarding the potential of red macroalgae in cancer treatment by discussing
the primary therapeutic targets of the disease and identifying compounds or extracts with bioactive characteristics
against them.
Discovery and Development of a Class of New Conversion (PDF) in Friedländer
Condensation of o-aminonitrile with Carbonyl Compounds
Authors: Duan Jianyu , Zhang Qi , Su Ziqi , Xu Juan , Yang Junjuan , Li Jiarong 
Published: July 2023

Abstract:
Since the discovery of the new conversion, through intramolecular Pinner to Dimroth
rearrangement to form a new skeleton product of dihydroquinazolinone in the normal
reaction of Friendländer quinoline synthesis of o-aminonitriles and carbonyl compounds, systematic
studies have shown that this conversion is a fast and efficient method for the synthesis
of nitrogen-containing heterocyclic compounds, especially pyrimidinone derivatives. In 2008,
we named this new transformation as a PDF conversion (a new conversion of dihydroquinolinone
skeleton compounds formed from intramolecular Pinner to Dimroth rearrangement in
the Friedländer quinoline synthesis). In this review, the research progress of PDF conversion
is systematically summarized from the following aspects: the discovery of PDF conversion,
the determination of the structure of new conversion products, the mechanism of PDF conversion,
a new type of organic bifurcation reaction, controllable PDF conversion, the breakthrough of conventional
PDF transformation forms, and the application of PDF conversion.
Covalent Modification of Proteins by Osthole Reactive Metabolites using Proteomic
Approaches
Authors: Zhuo Yue , Chen Huiling , Liu Chenchen , Zhang Yida , Fang Jiansong , Li Meng , Wang Zhendong , Jiang Qiyao , Yu Liangwen , Pan Huafeng , Wang Qi 
Published: July 2023

Background:
Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.)
Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β-
unsaturated lactone, which is an electrophilic group that tends to be metabolized into reactive metabolites (RMs).
Then, RMs are able to covalently modify nucleophilic amino acid (AA) residues of target proteins. However, few
researchers considered the contribution of the covalent modification induced by OST or its metabolites.

Objective:
This study aims to investigate the metabolic profile and the metabolites-protein modification of OST.

Methods:
The metabolites of OST were qualitatively identified using UHPLC-Q-TOF-MS. The RMs modification
patterns and potentially modified AA residues were confirmed by UHPLC-Q-TOF-MS using rat liver microsomes
(RLMs) and model AAs. Finally, the modified peptides derived from high-abundance microsomal peptides were
separated via nano-LC-Orbitrap-MS, and then RM-modified proteins were identified using a proteome discoverer.

Results:
In the presence of RLMs, OST could rapidly be metabolized within 1 h and hardly identified at 4 h. We
detected 10 OST metabolites, 13 OST metabolites-NAC (N-acetyl cysteine) adducts, 3 NAL (N-acetyl lysine) adducts,
and 11 GSH (glutathione) adducts. Furthermore, 16 RM-modified protein targets were identified, many of
which are included in the essential biological processes of OST’s anti-Alzheimer’s disease (AD) and anti-tumor.

Conclusion:
This study provides a novel perspective on the molecular mechanism of OST's pharmacological activities,
as well as identifies potential targets for further development and application of OST and other Natural products (NPs).
Monoclonal Antibodies and Antibody-drug Conjugates as Emerging Therapeutics for Breast Cancer Treatment
Authors: Saini Swati , Gulati Nisha , Awasthi Rajendra , Arora Vimal , Singh Sachin Kumar , Kumar Shobhit , Gupta Gaurav , Dua Kamal , Pahwa Rakesh , Dureja Harish 
Published: July 2023

Abstract:When breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT3, became commercially available. mAbs can resist the expansion of cancer cells by inducing the destruction of cellular membranes, blocking immune system inhibitors, and preventing the formation of new blood vessels. mAbs can also target growth factor receptors. Understanding the molecular pathways involved in tumor growth and its microenvironment is crucial for developing effective targeted cancer therapeutics. Due to their unique properties, mAbs have a wide range of clinical applications. Antibody-drug conjugates (ADCs) are drugs that improve the therapeutic index by combining an antigen-specific antibody with a payload. This review focuses on the therapeutic applications, mechanistic insights, characteristics, safety aspects, and adverse events of mAbs like trastuzumab, bevacizumab, pertuzumab, ertumaxomab, and atezolizumab in breast cancer treatment. The creation of novel technologies utilizing modified antibodies, such as fragments, conjugates, and multi-specific antibodies, must be a central focus of future studies. This review will help scientists working on developing mAbs to treat cancers more effectively.
Aortic Intima-Media Thickness is Increased in Neonates of Mothers with
Gestational Diabetes Mellitus: The Role of Thioredoxin-Interacting
Protein as a Marker of Oxidative Stress
Authors: Triantafyllidou Pinelopi , Papadopoulou Anna , Thymara Eirini , Papaevangelou Vassiliki , Mastorakos George , Papadimitriou Anastasios , Kalantaridou Sophia , Stratakis Constantine A. , Alexopoulou Efthymia 
Published: July 2023

Background:
Offspring exposed in foetal life to gestational diabetes mellitus (GDM) are at
increased risk for future metabolic diseases.

Objective:
To explore the prognostic role of abdominal aorta intima-media thickness (aIMT) in neonates
exposed to GDM as a possible biomarker for later atherogenesis and its possible correlation with thioredoxin-
interacting protein (TXNIP), a protein involved in oxidative stress.

Methods:
In this prospective, observational study, mother-infant pairs were studied in 2 groups (57
patients with GDM and 51 controls without GDM). TXNIP levels were measured in the placenta, as
well as in the umbilical and neonatal blood. The data were correlated with aIMT in neonates.

Results:
aIMT was increased in GDM offspring (patients: median [range]=0.39 mm [0.31-0.46] vs controls:
median=0.28 mm [0.23-0.33]; p=0.001) and remained significant after adjusting for possible confounders
(e.g., triglycerides, blood pressure, vitamin D, birth weight and gender; β coefficient=0.131
p=0.049). TXNIP levels were increased in trophoblasts (p=0.001) and syncytiotrophoblasts (p=0.001)
and were decreased in endothelial cells (p=0.022) in GDM offspring vs controls. Moreover, TXNIP
levels in trophoblasts positively correlated with aIMT (r=0.369; p=0.001). TXNIP levels in umbilical/
neonatal blood were not associated with GDM.

Conclusion:
Increased aIMT was demonstrated in the offspring of mothers with GDM. Non-invasive
measurement of aIMT could be used as a biomarker to identify children at increased risk for atherogenesis
later in life. This information may encourage early preventive measures. TXNIP may be associated
with GDM and/or aIMT.
A Review on Malnutrition in Children: Management and Treatment
Authors: Majumdar Ashish , Shukla Shiv Shankar , Pandey Ravindra Kumar 
Published: July 2023

Abstract:
Malnutrition in children is a major problem in developing countries. An increased
number of children are dying because of a lack of nutrition in their regular diet. The nutritional
value of food during the growing stage of children is important. The development of the human
body requires various types of nutrition for normal growth, which is obtained from a regular
healthy diet. In this study, an exhaustive literature survey was done using Pubmed, Google Scholar,
and various other internet sources, and also other reference records were studied. This review
highlighted the causes and consequences of the perpetual lack of a healthy diet that leads to malnutrition.
It also summarized the steps taken for the management and treatment of malnutrition.
This review may be a vital tool for the researchers working on malnutrition for its proper understanding.
Adverse Effects of Gefitinib on Skin and Colon in a Lung Cancer Mouse
Model
Authors: Wang Yalei , Cheng Shuo , Zhang Huawei , Zhang Yali , Ding Chengcheng , Peng Tiantian , Chen Weihang , Yang Ke , Zhang Jiani , Tan Yan , Wang Xu , Liu Zhaoheng , Wei Peng , Jiang Miao , Hua Qian 
Published: July 2023

Background:
Gefitinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
(EGFR-TKI), frequently causes side effects when used to treat non-small cell lung cancer

Objective:
The purpose of this experiment was to investigate the side effect of gefitinib on the skin
and colon of mice.

Methods:
Male Balb/c nu-nu nude mice aged 4-5 weeks were used as xenograft tumor models,
and gefitinib at 150 mg/kg and 225 mg/kg was started at 9 days after the xenograft tumor grew
out. The mice's weights and tumor volumes were tracked concurrently, and the mouse skin adverse
reactions and diarrhea were observed during the treatment. The animal tissues were subjected
to biochemical and pathological evaluations after 14 days.

Results:
Gefitinib effectively decreased the size and weight of transplanted tumors in nude mice,
while also lowering body weight and raising indexes of the liver and spleen. Gefitinib could cause
skin adverse reactions and diarrhea in mice. Further pathological investigation revealed tight junction-
related markers in the mice's skin and colon to be reduced and macrophages and neutrophils
to be increased after gefitinib treatment

Conclusion:
The findings imply that gefitinib has negative effects on the skin and colon. Gefitinib-
induced skin and colon adverse reactions in mice have been successfully modeled in this
study.
Screen Printed Electrodes: A Boon for Forensic Chemistry Analysis for
Detection of Narcotics and Explosives
Authors: Patil Ketan , Pandey Astha , Krishna Rohith 
Published: July 2023

Abstract:
Screen printing technology is a method of ink-based printing that utilizes a stencil mesh screen to create a visual pattern on a flat surface, such as plastic or silk. This process finds application in the production of screen-printed electrodes, which are utilized in electrochemical cells as part of voltammetric techniques. These electrodes offer advantages in terms of simplicity, portability, and ease of use compared to more intricate techniques. Various voltammetric methods are employed to analyze materials present in trace quantities, including drugs and explosives. By employing screen-printed electrodes in these electro-analytical techniques, it becomes possible to achieve straightforward, cost-effective, sensitive, and rapid detection of analytes with forensic significance. This highlights the significance of screen-printed electrodes in both onsite and laboratory forensic examinations.
Testing a Culturally Tailored Advance Care Planning Intervention (MY WAY) for an American Indian Tribe: Protocol for a Quasi-Experimental Waitlist Control Design
Authors: Anderson Elizabeth , Goins R Turner , Haozous Emily A , Schweinhart April 
Published: July 2023

Background
American Indian and Alaska Native peoples experience poor end-of-life care, including more hospitalizations and lower use of hospice and do-not-resuscitate orders. Although advance care planning (ACP) can improve end-of-life care, ACP rates are disproportionately low in American Indians and Alaska Natives.

Objective
We culturally tailored and delivered an existing evidence-based ACP program for an American Indian tribal community. Here, we present the protocol for assessing the intervention’s feasibility and efficacy.

Methods
We measured feasibility via participant recruitment, participants’ evaluation (acceptability, appropriateness, comprehension, and satisfaction), and intervention fidelity. Recruitment was measured with participant screening, eligibility, enrollment, and retention. Participant’s evaluation of the intervention was measured with surveys. Fidelity was measured with direct observation and the Make Your Wishes About You (MY WAY) Fidelity Checklist Tool. To assess the intervention’s efficacy, we used a quasi-experimental waitlist control design with 2 cohorts who were surveyed each on three separate occasions. The intervention’s efficacy was assessed by the following: ACP barriers and facilitators as well as ACP self-efficacy, readiness, and completion.

Results
A total of 166 participants were screened for eligibility; 11 were deemed ineligible, and 155 participants were enrolled in the study. Of those enrolled, 113 completed the intervention and will be included in subsequent analyses. We finalized data collection in January 2023, and analyses are underway. Study enrollment was successful, and we expect that participants will report high levels of acceptability, appropriateness, comprehension, and satisfaction with the intervention. We expect that the intervention was implemented with fidelity and will demonstrate decreases in ACP barriers and increases in ACP facilitators, self-efficacy, readiness, and completion.

Conclusions
Enrolling over twice as many participants as we had hoped suggests that members of this tribal community are willing to engage in end-of-life ACP. We were able to implement a waitlist study design to show that a culturally tailored ACP program for a tribal community is feasible.

Trial Registration
ClinicalTrials.gov NCT05304117; https://clinicaltrials.gov/study/NCT05304117

International Registered Report Identifier (IRRID)
DERR1-10.2196/50654
Calidad de tesis de grado en educación médica en Perú: Un estudio transversal
Authors: Cordero-Chunga Aldrín Gabriel , Flores-Cohaila Javier Alejandro 
Published: July 2023

Introducción: La baja tasa de publicación de las tesis de grado de educación médica en Perú limita el avance y la innovación de esta área. Se ha reportado que la calidad de la investigación en educación médica se asocia con la publicación en revistas científicas. Es por ello esencial identificar y mejorar la calidad de estos productos académicos.
Objetivo: Describir la calidad de la tesis de pregrado enfocadas en educación médica de Perú usando el instrumento Medical Education Research Study Quality Instrument e identificar que otros factores influyen en la calidad.
Método: Realizamos un estudio transversal analítico tomando como unidad de análisis a las tesis de grado enfocadas en educación médica ubicadas en el repositorio de Acceso Libre a la Información Científica para la Innovación de Perú. Evaluamos la calidad usando el MERSQI, otras variables recolectadas fueron: año de publicación, tipo de universidad, tesis publicada, experiencia del asesor y temática. Realizamos un análisis estadístico para identificar diferencias entre el MERSQI con respecto a la experiencia del asesor, si la tesis fue publicada y el tipo de universidad.
Resultados: Analizamos 20 tesis de grado enfocadas en educación médica. El MERSQI promedio fue de 9.13 ± 1.73. La mayoría de estudios fueron de diseño transversal y se enfocaron en estudiantes de medicina. El dominio peor calificado del MERSQI fue el de validez del instrumento. No encontramos diferencias significativas en el puntaje del MERSQI según tipo de universidad, tesis publicada y experiencia del asesor.
Conclusiones: Nuestros resultados identifican un MERSQI por debajo de la media internacional. Además, sugieren que existe una ausencia de asesores con experiencia en educación médica. Se requieren intervenciones para incrementar la calidad de la investigación en educación médica en Perú.
Virtualización de la metodología aprendizaje servicio y la percepción de los participantes durante la pandemia
Authors: Trunce-Morales Silvana Trinidad , Villarroel Quinchalef Gloria Del Pilar , García Alvarado Katherine Isabel , Trunce-Morales Juan Benito 
Published: July 2023

Introducción: El aprendizaje servicio virtual (APSv) se define como una modalidad innovadora que desarrolla aprendizajes significativos en los estudiantes y da respuesta a las necesidades de la comunidad sin restricciones geográficas. En la carrera de nutrición y dietética de una universidad pública del sur de Chile, se implementó el APSv, en la asignatura “Taller de nutrición clínica del adulto”.
Objetivo: Determinar la percepción de los estudiantes y socios comunitarios sobre la experiencia de virtualización de la estrategia aprendizaje servicio implementada.
Método: Diseño de modelo mixto, exploratorio, no experimental, descriptivo y de corte transversal. La muestra fue no probabilística intencional de 43 estudiantes y 22 socios comunitarios que cumplieron los criterios de inclusión. La estrategia de APSv se efectuó mediante 5 etapas y al finalizar se evaluó la percepción de los estudiantes mediante un grupo focal y autoevaluación. Los socios comunitarios respondieron la “Evaluación de la metodología aprendizaje servicio en virtualidad”. Los aspectos éticos fueron resguardados según los principios éticos de Helsinki.
Resultados: Se observó un alto nivel de satisfacción por parte de los socios comunitarios (sobre 90% “muy de acuerdo”). El promedio de autoevaluación de los estudiantes fue de 6.52 (escala de notas 1.0 a 7.0). Destacando que sobre el 90% están de acuerdo o muy de acuerdo con su desempeño en relación a las competencias genéricas. Con relación a la percepción del tiempo destinado, motivación, estudio de los contenidos y satisfacción, los alumnos manifestaron un promedio 66% estar “muy de acuerdo”. La estrategia APSv fue asociada a los conceptos de; competencias profesionales, motivación, comunicación efectiva, fortalezas, sentimientos, emociones, reflexión, retroalimentación, trabajo en equipo, virtualidad y sugerencias.
Conclusiones: El APSv favorece la integración de competencias que vinculan al estudiantado con la comunidad mediante herramientas digitales logrando un aprendizaje significativo, favoreciendo la responsabilidad social universitaria.
La monopolización del conocimiento universitario: “Un asalto a los valores de la academia”
Authors: Rodríguez Cervantes Silvia 
Published: July 2023

"Si he visto más lejos es porque estoy sentado sobre los hombros de gigantes" (Isaac Newton en carta de febrero de 1676 a Robert Hooke).
Esta frase célebre, erróneamente atribuida a uno de los más grandes científicos de todos los tiempos, Isaac Newton, había sido anteriormente empleada por pensadores y teólogos de la Edad Media y del Renacimiento. Cualquiera haya sido su autor, todos resumen, al utilizarla, su posición sobre el desarrollo del pensamiento científico como producto de la colaboración social. Según estos pensadores, sería entonces una aberración fraccionar los resultados de las investigaciones con la intención de hacerlos "propiedad intelectual" de alguien en un momento específico. Pareciera, sin embargo, que no todos coinciden con esa premisa. Más bien estamos en medio de una fuerte ofensiva que presiona a las universidades y centros de investigación privatizar el conocimiento.