bluuebunny/crossref_metadata_2025_split huggingface dataset:
(175) IMPACT OF PELVIC FLOOR DYSFUNCTIONS IN FEMALE SEXUALITY
Authors: Dr. Sònia Anglès-Acedo , Lorena López-Frías , Carolina Carmona-Guerrero , Esther Benito-García , Sílvia Escura-Sancho , Dr. Eduardo Bataller-Sánchez , Dr. Cristina Ros-Cerro , Dr. Montserrat Espuña-Pons 
Published: July 2023

Abstract

Objectives
To analyse female sexuality of women who seek care for pelvic floor dysfunctions.

Methods
Cross-sectional study about female sexuality of women attended the first consultation to assess and treat pelvic floor dysfunctions (urinary incontinence-IU, anal incontinence-IA, pelvic organ prolapse-POP). Urinary, anal and prolapse symptoms were assessed with B-SAQ, ICIQ-UI-SF, PFDI-20. PISQ-IR, a condition-specific questionnaire, was used for assessing sexuality in both non-sexually active (NSA) and sexually active (SA) patients.

Results
We included 131 participants, 89.3% reported UI, 37.4% AI and 30.5% had a symptomatic POP. The more frequently isolated pelvic floor dysfunction was UI (39.7%). 26% of the participants informed double incontinence. 46% of women presented 2 pelvic floor dysfunctions, whereas 8.4% had 3 of them. Table 1 shows the baseline characteristics.
NSA rate was 45%. The main reason for sexual inactivity was lack of interest (70.7%), followed by not having a partner (53.4%). The pelvic floor dysfunction, other health issues and the pain were the inactivity reason in a lower proportion (12.1%, 10.3% y 10.3%, respectively). 25.8% NSA women reported avoidance of sexual activity due to fear related to UI/AI or POP. 75.9% of NSA participants were satisfied with their sexual life.
Related to SA women (n=72), 36.5% informed about UI/AI during sexual activity, however, 57.7% of the SA participants limited sexual activity due to fear related to UI /AI or POP. Dyspareunia was present in 52.3% SA women. 59.1% of SA women were satisfied with their sexual life.

Conclusions
Most of our sample are interested in their sexuality assessment. Pelvic floor dysfunctions may affect sexual activity among NSA and SA women, as well as worsen sexual function on SA women. So, satisfaction with the sexual life could be impaired. PISQ-IR permits to identify the subgroup of patients with unsatisfied sexual life due to pelvic floor dysfunctions and, then, to individualized treatment according patient’s expectations.

Conflicts of Interest
No conflict of interest.
(229) FEMALE GENITAL SELF-IMAGE SCALE-SPANISH (FGSIS-S): PROPOSAL FOR A CUT-OFF SCORE
Authors: Dr. Alba Bartolomé , Cecilia Villalaín , Alvaro Tejerizo 
Published: July 2023

Abstract

Objectives
To explore cut-off scores for Female Genital Self-Image Scale-Spanish (FGSIS-S) to discriminate women concerned about their genital appearance and/or considering female genital cosmetic surgery (FGCS), most frequently labiaplasty.

Methods
FGSIS-S is a Spanish validated, 6-item scale, developed from original FGSIS. It measures women’s genital image self-perception. Total score varies from 6 to 24 and higher scores resemble a more positive attitude towards genital self-image.
Answers from 200 women taking part, through an online survey, in the FGSIS-S validation original study were analyzed. Participants were 18-70 years old, native Spanish-speakers, non-pregnant, without vulvar disease, attending general gynecology consults in Hospital 12 de Octubre, from march to may 2021.
Questions “Have you ever been concerned about your genital appearance?” and “Have you ever considered undergoing genital cosmetic surgery?” were validated and used for stratification of FGSIS-S scores.
Sensitivity and specificity analysis was performed through logistic regression and plot of the area under the ROC curve (AUC).

Results
Overall FGSIS-S score was able to predict women’s concern with an AUC of 0.80 (95% CI 0.74 – 0.86); and those considering FGCS with AUC 0.78 (95% CI 0.69 – 0.86).
A 90% sensitivity cut-off for the detection of women concerned was found at 21 and 17 for 90% specificity. Best trade-off between sensitivity (51.6%) and specificity (91.6%) was found at 17.
To detect women considering FGCS, cut-offs were found at 21 (90% sensitivity) and 15 (90% specificity). Best trade-off was found again at 17 (sensitivity 72.0%, specificity 81.1%)
Cut-off scores are shown in FIgure 1.

Conclusions
We consider 17 could be a good cut-off to refer women to specialized counselling as they probably represent the most extreme group of those concerned and considering surgery.
Further studies are needed to validate cut-off scores as well as establish the total score increment required to obtain clinical benefit from interventions.

Conflicts of Interest
The authors report no conflicts of interest.
(49) HIV KNOWLEDGE AND STIGMA TOWARDS HIV-POSITIVE PEOPLE: AN EMPIRICAL STUDY
Authors: Dr. Sofia Falaschi , Paolo Antonelli , Dr. Daniel Giunti , Dr. Gioele A Salvatori , Prof. Davide Dèttore 
Published: July 2023

Abstract

Objectives
Our study investigates the Italian population’s level of knowledge about HIV and how it influences the perceived stigma towards HIV-positive people. Specifically, we evaluated the association between socio-demographic variables and the level of knowledge regarding transmission, high-risk behaviors and prevention with respect to HIV, and the association between such variables and the perceived stigma towards HIV-positive individuals. We hypothesized that knowledge about HIV would be negatively correlated with participants’ age and with the perceived stigma towards HIV-positive people.

Methods
5256 individuals took part in the study, 54 of whom reported being HIV-positive. Participants were given a questionnaire aimed at gathering socio-demographic information, at investigating knowledge on the topic of HIV, and at assessing the level of stigma they perceived towards HIV-positive individuals.

Results
Participants answered correctly to an average of 86.4% of the answers, but the percentage was lower for seronegative respondents (82.6%) compared to seropositive ones (90.2%). Significant but weak positive correlations were observed between knowledge regarding HIV, on one side, and, on the other, participant’s age and perceived stigma. A higher level of knowledge about HIV was associated with a higher education and with the main source of information on the matter, with those relying mostly on the media being the least informed. Moreover, condom use tends to decrease with age. As regards HIV-positive respondents, the younger their age the more they felt that their serostatus negatively impacted their self-image.

Conclusions
Our study highlights that, although our sample showed a good overall knowledge about HIV, several areas resulted lacking and should be the target of future sensibilization campaigns. Perceived stigma resulted weakly correlated with the variables we considered, but future research should aim at gaining a deeper understanding of the factors that influence it.

Conflicts of Interest
The authors declare no conflict of interest.
(62) TUNNELING IN A CASE OF SEVERE CAVERNOUS FIBROSIS AFTER PENILE IMPLANT INFECTION
Authors: Dr. Maurizio D'Anna , Josep Torremadé , Dr. Meritxell Costa , Dr. Roger Matheu , Lluis Peri , Prof. Antonio Alcaraz 
Published: July 2023

Abstract

Objectives
Penile implant can be a challenging procedure when cavernosal fibrosis is encountered. In some cases, a second incision and more aggressive maneuvers may be necessary, such as fibrotic tissue ressection, widening of the corporotomies, and grafting in order to close the cavernous bodies. Tunneling is a less invasive technique that allows the development of a space inside the cavernous body to implant the prosthesis.

Methods
We present a case of a 36-year-old patient who underwent suspensory ligament section and, later on, an implant of a two-piece inflatable penile prosthesis. He presented to our hospital a month later, with sepsis and a penoscrotal abscess. After urgent removal of the prosthesis and skin debridement, the patient developed a urethrocutaneous fistula that was subsequently repaired. A physical examination was performed, fibrosis didn’t allow penile stretching. Patient was scheduled for a three-piece inflantable penile prostesis implant.

Results
In this video we show a step-wise management of a patient with cavernosal fibrosis. After development of a space with Metzembaum scissors, tunneling is performed with Mooreville Uramix dilators and Rosselló cavernotomes. This made possible the implantation of a Titan Touch narrow-base penile prosthesis.

Conclusions
Tunneling of the cavernosal bodies is a useful technique in cases with extensive cavernosal fibrosis due to previous infection.

Conflicts of Interest
No conflict of interest.
(277) A CASE OF PENILE-SCROTAL RECONSTRUCTION DUE TO MALE GENITAL LYMPHOEDEMA
Authors: Matthew Megson , Prof. David Ralph 
Published: July 2023

Abstract

Objectives
This is a case of scrotal lymphoedema in a 36 year old gentleman who had had 3 years of recurrent infections. Due to the extent of the disease he required an excision of the lymphoedematous tissue and a scrotoplasty to reconstruct his scrotum from unaffected skin.

Methods
This is a video demonstrating the steps of the excision of the lymphoedematous tissue and subsequent reconstructive. Steps of the procedure start with marking of the lymphoedematous tissue. The surgeon the dissects down the isolate the cords and delivers the testes. The penile shaft can then be isolated and all lymphoedematous tissue excised. With the important structures now isolated, the scrotal lymphoedematous tissue can be removed. Care must be taken to keep the unaffected skin on the lateral aspects of the wounds, as these have a different lymphatic drainage and are therefore not involved in the pathology. This creates an ideal tissue for reconstruction as this allows primary closure of the neo-scrotum. The lymphoedematous tissue tends to be extremely vascular with large feeding vessels, therefore care much be taken with haemostasis. Due to the lymphoedematous tissue extending into the patients perineum he was then placed into lithotomy to allow better access to this area. Care was taken to avoid injury to the anus and rectum. Prior to the close of the neo-scrotum an Orchidopexy was performed to stop testicular retraction. The lateral skin was then closed to create a neo-scrotum over drains.

Results
The video shows a typical operation for male genital lymphoedema and the usual end results. The patient is happy with his final result. The histology showed an anogenital granulomatosis lymphoedema.

Conclusions
A variety of treatment options for anogenital granulomatosis exist though if left to become severe then surgery is required before any of these medications would improve future outcomes.

Conflicts of Interest
No conflict of interest to declare.
(128) EVALUATION OF DONOR-SITE MORBIDITY AFTER RADIAL FOREARM FLAP ELEVATION FOR TOTAL PHALLIC RECONSTRUCTION IN TRANSGENDER MEN
Authors: Marco Falcone , Dr. Mirko Preto , Dr. Davide Ciclamini , Dr. Federica Peretti , Dr. Lorenzo Cirigliano , Dr. Ilaria Ferro , Dr. Natalia Plamadeala , Dr. Carlo Ceruti , Prof. Paolo Gontero 
Published: July 2023

Abstract

Objectives
Radial artery forearm free-flap (RAFFF) phalloplasty is the main technique used to total phallic construction (TPC) in transgender men. Donor-site morbidity has been rarely investigated. The study aims to evaluate the surgical and functional outcomes of donor site reconstruction.

Methods
It is a retrospective analysis of TPC with RAFFF performed from 2016 to 2022. Were considered as outcome measures: duration of the procedure, hospital stay, size of the donor-site defect, and postoperative complication rate. Validated tools and questionnaires used for functional outcomes evaluation were: Vancouver and POSAS scale, Scar Pinch Test, and aROM. Patient-reported outcomes were inquired using a 3 items ad-hoc created questionnaire. A subanalysis was made according to the donor site reconstruction technique: Group A a full-thickness skin graft (FTSG); Group B a single-layer dermal matrix with split-thickness skin (STSG) graft.

Results
Group A included 18 (53%) patients, whereas group B 16 (47%) patients. Mean follow-up was 24 months (IQR 11-40). The median donor-site defect was 302 cc (IQR 306-323, p=0.21). Early postoperative complications were described in 23.5% of cases. Mean graft take was 91%. A complete graft take was detected in 58.9% of the patients, with a significant advantage for group B (93.8%) respect to group A (27.8%) (p= 0.0001). In Group B a significantly shorter operative time (310min vs 447min p= 0.0001) and a reduced median hospital stay (8 days vs 10 days p= 0.001) were detect. Overall 80% of patients were satisfied with the appearance of the arm, and 92% with the post-surgery functionality. The analysis reveals that Group B reached a significantly higher satisfaction rate for arm appearance compared to group A (94% vs 66% p = 0.048).

Conclusions
FTSG or single layer dermal matrix with STSG for donor-site reconstruction after RAFFF provides satisfactory surgical, functional and aesthetic outcomes.

Conflicts of Interest
None to declare.
(188) ISOFORMS OF THE CYCLIC GMP-DEPENDENT PROTEIN KINASE ARE EXPRESSED IN HUMAN PENILE ERECTILE TISSUE
Authors: Dr. Viktoria Märker , Prof. Stefan Ueckert , Priv-Doz. Eginhard Waldkirch , Prof. Petter Hedlund 
Published: July 2023

Abstract

Objectives
Aside from the activity of the gaseous transmitter molecule nitric oxide (NO) and the cyclic GMP producing enzyme soluble guanylyl cyclase (sGC) in human penile erectile tissue, intracellular receptor proteins activated by the binding of cyclic GMP have been considered to play a significant role in the erection process. In animal models, a down-regulation of the cyclic GMP-dependent/binding protein kinase I (cGKI) has been linked to the on-set of diabetes mellitus and erectile dysfunction (ED). Our study aimed to investigate in human penile erectile tissue (corpus cavernosum and cavernous arteries) the expression of cGKI (isoforms alpha and beta) in relation to smooth muscle alpha-actin, cyclic GMP and the endothelial nitric oxide synthase (eNOS).

Methods
Cryostat sections of human penile erectile tissue were exposed to primary antibodies (ABs) directed against alpha-actin, cGKI, cGKI alpha and cGKI beta, cyclic GMP and eNOS, followed by the incubation with fluorochrome-labeled secondary ABs. Visualization was commenced by means of laser fluorescence microscopy. Western blot analysis was also performed.

Results
Abundant immunoreactivities indicating the presence of cGKI alpha and beta and the second messenger cyclic cGMP were observed in the trabecular smooth musculature as well as in the smooth muscle layer of tiny cavernous arteries. Double staining revealed the co-localization of cGKI and eNOS within the endothelium of small arterial vessels. The expression of cGKI alpha and beta was confirmed by Western blot analysis.

Conclusions
Theclose relation of isoforms of the cGKI to key mediators of the NO pathway (eNOS, cyclic GMP), as demonstrated by conventional immunohistochemistry, provides further evidence for a significant role of cyclic GMP-binding intracellular function proteins in the control of vascular and non-vascular penile erectile smooth muscle.

Conflicts of Interest
no conflict of interest.
(60) THE PREVALENCE AND SEVERITY OF SEXUAL DYSFUNCTION IN MALE IBD PATIENTS: AN OBSERVATIONAL SINGLE-CENTER STUDY
Authors: Dr. Alessandro Brunetti , Dr. Walter Vena , Dr. Arianna Dal Buono , Dr. Ludovico Alfarone , Dr. Roberto Gabbiadini , Dr. Laura Loy , Dr. Virginia Solitano , Dr. Ferdinando D'Amico , Dr. Simone Antonini , Prof. Andrea Lania , Prof. Gherardo Mazziotti , Prof. Alessandro Armuzzi , Dr. Alessandro Pizzocaro 
Published: July 2023

Abstract

Objectives
Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong disabling disorders with a significant impact on the quality of life (QoL). Previous studies reported that sexual dysfunction (SD) could affect 25-45% of male IBD patients, compared to 5-15% in the general population of the same age. However, this topic has not attracted widespread attention, and thus research studies are scarce. Our study aims to determine prevalence and severity of SD in a cohort of male IBD patients and to identify the associated risk factors.

Methods
This is an observational single-center study. From July 2021 to June 2022, male IBD patients were invited to fill the International Index of Erectile Function (IIEF-15) questionnaire during scheduled visits. Clinical data, including treatment history, disease activity and previous surgery, were collected.

Results
61 patients, 33 with CD and 28 UC, were enrolled. Median age was 33.8 years (range, 19.7–63.7); median body mass index (BMI) was 26.5 kg/m2 (range, 17.6–31.9). Almost half of the subjects were active or former smokers (49.1%). 81.9% of patients were receiving biological therapies and 42.6% had an history of IBD-related surgery. The median total IIEF score was 64 (range, 18-75). 25.4% of patients reported erectile dysfunction (ED), according to EF subscore (EF-S). At univariate analysis age (p=0.001), calprotectin levels (p&lt;0.05) and biological therapy (p&lt;0.05) were significantly associated with total IIEF score; age (p=0.003) and calprotectin levels (p&lt;0.05) significantly correlated with EF-S. At multivariate analysis, age and calprotectin levels maintained significant association with both total IIEF score (p=0.003 and p= 0.002, respectively) and EF-S (p=0.001 and p=0.01, respectively).

Conclusions
A quarter of IBD patients reported ED in our study, a remarkably higher proportion compared to healthy subjects of the same age. Therefore, gastroenterologist should investigate sexual function in IBD patients and, if indicated, promptly refer them for andrological evaluation ito improve their QoL.

Conflicts of Interest
Authors report no conflicts of interest.
(141) DETAILED CHARACTERISATION OF PATIENTS UNDERGOING DYNAMIC PENILE COLOR DOPPLER DUPLEX ULTRASOUND FOR ERECTILE DYSFUNCTION – FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY
Authors: Dr. Edoardo Pozzi , Dr. Alessandro Bertini , Dr. Giuseppe Fallara , Dr. Federico Belladelli , Dr. Simone Cilio , Dr. Massimiliano Raffo , Fausto Negri , Ludovica Cella , Margherita Fantin , Dr. Christian Corsini , Dr. Francesco Lanzaro , Dr. Luigi Candela , Dr. Paolo Capogrosso , Dr. Luca Boeri , Dr. Alessia d'Arma , Prof. Francesco Montorsi , Prof. Andrea Salonia 
Published: July 2023

Abstract

Objectives
Dynamic penile Color Doppler Duplex Ultrasound (CDDU) is an effective tool to assess of men with vasculogenic erectile dysfunction (ED). We aimed to describe clinical and sociodemographic characteristics of men with parameters suggestive of normal vs. arteriogenic ED at CDDU, and to identify potential predictors of arteriogenic ED at CDDU.

Methods
Complete data of 245 consecutive patients undergoing CDDU for ED were analysed. Comorbidities were scored using the Charlson comorbidity index (CCI). All patients completed the International Index of Erectile Function (IIEF) at baseline. Serum hormones were dosed for every patient. CDDU was performed after intracavernosal injection of Alprostadil 20 microGr. Arteriogenic ED was defined with a peak systolic velocity (PSV) &lt;35cm/s at CDDU. Patients with deficient veno-occlusive mechanisms were excluded from the analyses. Patients were divided into with normal parameter vs. parameters suggestive for arteriogenic ED at CDDU. Descriptive statistics compared the clinical and sociodemographic characteristics of the two groups. Logistic regression models explored the potential predictive factors of arteriogenic ED at CDDU.

Results
Overall, median (IQR) age was 53 (42-60) yr and right/left PSV were 42.3(32.4-55.1) and 42.4(31.9-54.1) cm/s respectively. Of all, 81 (33.1%) had arteriogenic ED at CDDU. Patients with arteriogenic ED were older (59vs.50yr, p&lt;0.001), had higher BMI (26.54vs.25.12 kg/m2, p=0.005), higher rates of CCI≥1 (64.2%vs. 43.9%, p=0.006), arterial hypertension (37%vs. 19.5%, p=0.005), smoking (28%vs. 13.6%, p=0.002) but lower rates of regular physical exercise (50.6%vs. 54.9%, p=0.04) compared to patients with normal CDDU parameters. No other statistical differences were found. At multivariable logistic regression analysis, the only predictor of arteriogenic ED was age (OR: 1.07, 95%CI: 1.01-1.14, p=0.03) after adjusting for BMI, CCI≥1, arterial hypertension, severe ED, and regular physical exercise.

Conclusions
One out of three men undergoing CDDU for ED depict criteria suggestive of arteriogenic ED. Similar rates of severe ED were found between men with normal and pathological CDDU parameters. Older age was identified as the only predictive factor of arteriogenic ED at CDDU.

Conflicts of Interest
N/A
(228) SATISFACTION AND PERSPECTIVES OF TELEMEDICINE IN ANDROLOGY
Authors: Rodrigo Garcia-Baquero , Araceli Ogalla Garcia , Margarita Fernandez Avila Cristina , Luis Alvarez Ossorio Jose 
Published: July 2023

Abstract

Objectives
Telemedicine was established as an essential tool for healthcare due to the last pandemic by COVID19. The objective of this study is to know the assessment of the patients of the Andrology thematic consultation of the telephone teleconsultations carried out during the pandemic.

Methods
We conducted a retrospective study by reviewing medical records, and cross-sectional by telephone survey, of a group of patients randomly selected from our Andrology section. Satisfaction with remote assistance was carried out using the validated TSQ questionnaire (Telemedicine Satisfaction Questionnaire) and a self-designed opinion questionnaire with 7 items in relation to their attitude towards teleconsultation as a regular practice in the future.

Results
A total of 92 patients were selected, of whom 78 participated in the study (response rate of 84.8%). All of them were men with a mean age of 58 years. 67.5% consulted for erectile dysfunction, 22.1% for Peyronie's disease, 2.6% for premature ejaculation, and 7.8% for infertility. Overall, 70.0% were satisfied with the quality of the service provided during the pandemic. 48.1% would agree with incorporating teleconsultation as an option for their assistance in the future, preferably for reading the results of complementary tests requested (57.1%). We found no correlations between satisfaction with the telephone consultation and age (p 0.49), sociocultural level (p 0.34), employment status (p 0.31), distance from the hospital (p 0.83), disease risk factors severe by Covid19 (p 0.35), the Charlson index (p 0.59), nor the pathology for which they suffered (p 0.26).

Conclusions
The telephone consultation as a telemedicine option has been well received by the majority of our patients with andrological pathology. The predisposition of a good part of our patients for their use in the future can be a useful tool to reduce the usual care load, considering the situation and individual preferences.

Conflicts of Interest
No conflict of interest with this presentation.