bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining inappropriate medication in UK primary care for type 2 diabetes patients with polypharmacy
Authors: Faquetti Maria Luisa , Frey Géraldine , Stämpfli Dominik , Weiler Stefan , Burden Andrea M. 
Published: May 2023

AbstractAimsTo estimate the prevalence of potentially inappropriate prescriptions (PIPs) in patients starting their first non-insulin antidiabetic treatment (NIAD) using two explicit process measures of the appropriateness of prescribing in UK primary care, stratified by age and polypharmacy status.MethodsA descriptive cohort study between 2016 and 2019 was conducted to assess PIPs in patients aged ≥45 years at the start of their first NIAD, stratified by age and polypharmacy status. The American Geriatrics Society (AGS) Beers criteria 2015 was used for older (≥65 years) and the Prescribing Optimally in Middle-age People’s Treatments (PROMPT) criteria for middle-aged (45-64 years) patients. Prevalence of overall PIPs and individual PIPs criteria was reported using the IQVIA Medical Research Data incorporating THIN, a Cegedim Database of anonymised electronic health records in the UK.ResultsAmong 28,604 patients initiating NIADs, 18,494 (64.7%) received polypharmacy. In older and middle-aged patients with polypharmacy, 39.6% and 22.7%, respectively, received ≥1 PIPs. At the individual PIPs level, long-term PPI use and strong opioid without laxatives were the most frequent PIPs among older and middle-aged patients with polypharmacy (11.1% and 4.1%, respectively).ConclusionsThis study revealed that patients starting NIAD treatment receiving polypharmacy have the potential for pharmacotherapy optimisation.
INVESTIGATING HEALTH PROFESSIONALS’ UNDERSTANDING AND RISK PERCEPTION OF THE EFFECT OF CLIMATE CHANGE ON HEALTH. A CROSS-SECTIONAL STUDY OF HEALTH PROFESSIONALS AT THE SDA HOSPITAL, REGIONAL HOSPITAL AND MUNICIPAL HOSPITAL-SUNYANI, GHANA
Authors: Barimah Antwi Joseph , Abdul-Ganiyu Mansurat , Ibrahim Mohammed Mohammed , Allotey Solomon Saka , Commey Rebecca Dorcas , Osei-Tutu Angelo Guapem , Nketiah Yaw Boakye , Amoah Bernard Opoku , Agyemang Larry , Dumba James , Gyamea Helina 
Published: May 2023

AbstractThe study investigated health professionals’ understanding and risk perception of climate change in the Sunyani Municipality by focusing on health professional’s knowledge on climate change, examining health professional’s risk perception of climate change on health and identifying the co-benefits of climate change mitigation. This quantitative oriented cross-sectional study randomly selected 400 health professionals across the Regional Hospital, SDA Hospital and Municipal Hospital as respondents. Quantitative data was analyzed using SPSS Version 25. From the study, the results indicate that Health professionals are fully aware of the concept of climate change. Health professionals do not have knowledge pertaining to the scientific aspects of climate change. There was a statistical relationship between respondent’s perception that climate change can lead to death (P<0.001) and their awareness of the risk of climate change impact on health. There was a general likelihood of an increase in malaria (Mean=2.98), Dengue fever (Mean=3.16), Cholera (Mean= 3.18), schistosomiasis (Mean=3.27), Meningococcal meningitis (Mean=3.85) and Influenza (Mean=3.73) due to climate change. These actions positively affect health and climate and they include: Giving up red meat (Mean=3.21), Walking and cycling instead of using cars (Mean=3.27), Reducing rural-urban migration (Mean=3.46), Reducing air pollution from emission of fossil fuel (Mean=3.63). A majority of 65% of respondents agreed to the incorporation of climate change related course work into nursing/medical school curricula as a policy to mitigate climate change. The study concludes that health professionals are fully aware about climate change but lack a thorough understanding of the scientific aspects of climate change. The general risk perception of health professionals towards climate change impact on health was high. Climate change mitigation is beneficial to human populations.
CEMIG: Prediction of thecis-regulatory motif using the De Bruijn graph from ATAC-seq
Authors: Wang Yizhong , Li Yang , Wang Cankun , Ma Qin , Liu Bingqiang 
Published: May 2023

AbstractsSequence motif discovery algorithms identify novel DNA patterns with significant biological roles, such as transcription factor (TF) binding site motifs. Chromatin accessibility data, accumulated through assay for transposase-accessible chromatin with sequencing (ATAC-seq), has enriched resources for motif discovery. However, computational efforts in ATAC-seq data analysis mainly target TF binding activity footprinting rather than motif prediction. Here, we introduce CEMIG, an algorithm predicting and characterizing TF binding sites, leveraging the De Bruijn and Hamming distance graph models. Evaluation of 129 ATAC-seq datasets from the Cistrome Data Browser suggests that CEMIG outperforms three widely used methods using four metrics. It is noteworthy that CEMIG is employed to predict cell-type-specific and shared TF motifs in GM12878 and K562 cells, facilitating comprehensive gene expression and functional genomics analysis.
Schwann cell release of p11 induces sensory neuron hyperactivity in Fabry disease
Authors: Waltz Tyler B. , Chao Dongman , Prodoehl Eve K. , Ehlers Vanessa L. , Dharanikota Bhavya S. , Dahms Nancy M. , Isaeva Elena , Hogan Quinn H. , Pan Bin , Stucky Cheryl L. 
Published: May 2023

AbstractPatients with Fabry disease suffer from chronic debilitating pain and peripheral sensory neuropathy with minimal treatment options, but the cellular drivers of this pain are unknown. Here, we propose a novel mechanism by which altered signaling between Schwann cells and sensory neurons underlies the peripheral sensory nerve dysfunction we observe in a genetic rat model of Fabry disease. Usingin vivoandin vitroelectrophysiological recordings, we demonstrate that Fabry rat sensory neurons exhibit pronounced hyperexcitability. Schwann cells likely contribute to this finding as application of mediators released from cultured Fabry Schwann cells induces spontaneous activity and hyperexcitability in naïve sensory neurons. We examined putative algogenic mediators using proteomic analysis and found that Fabry Schwann cells release elevated levels of the protein p11 (S100-A10) which induces sensory neuron hyperexcitability. Removal of p11 from Fabry Schwann cell media causes hyperpolarization of neuronal resting membrane potential, indicating that p11 contributes to the excessive neuronal excitability caused by Fabry Schwann cells. These findings demonstrate that rats with Fabry disease exhibit sensory neuron hyperexcitability caused in part by Schwann cell release of the protein p11.Graphical Abstract
Retrospective Review of Blood Culture-Confirmed Cases of Enteric Fever in Navi Mumbai, India: 2014–2018
Authors: Jayaprasad Niniya , Borhade Priyanka , LeBoa Christopher , Date Kashmira , Joshi Shrikrishna , Shimpi Rahul , Andrews Jason R. , Bhatnagar Pankaj , Luby Stephen P. , Hoffman Seth A. 
Published: May 2023

AbstractIndia has one of the highest estimated burdens of enteric fever globally. Prior to implementation of Typbar-TCV®typhoid conjugate vaccine (TCV) in a public sector pediatric immunization campaign in Navi Mumbai, India, we conducted a retrospective review of blood culture-confirmed cases of typhoid and paratyphoid fevers to estimate the local burden of disease. This review included all blood cultures processed at a central microbiology laboratory, serving multiple hospitals, in Navi Mumbai (January 2014–May 2018) that tested positive for eitherSalmonellaTyphi orSalmonellaParatyphi A. Of 40,670 blood cultures analyzed, 1,309 (3.2%) were positive for S. Typhi (1,201 [92%]) or S. Paratyphi A (108 [8%]). Culture positivity was highest in the last months of the dry season (April-June). Our findings indicate a substantial burden of enteric fever in Navi Mumbai and support the importance of TCV immunization campaigns and improved water, sanitation, and hygiene.
The developmental genediscoregulates diel-niche evolution in adult moths
Authors: Sondhi Yash , Messcher Rebeccah L. , Bellantuano Anthony J. , Storer Caroline G. , Cinel Scott D. , Godfrey R. Keating , Glass Deborah , St Laurent Ryan A. , Hamilton Chris A. , Earl Chandra , Brislawn Colin J. , Kitching Ian J. , Bybee Seth M. , Theobald Jamie C. , Kawahara Akito Y. 
Published: May 2023

AbstractAnimals shift activity periods to reduce predation, minimize competition, or exploit new resources, and this can drive sensory system evolution. But adaptive mechanisms underlying niche- shifts are poorly understood, and model organisms are often too distantly related to reveal the genetic drivers. To address this, we examined expression patterns between two closely related silk moths that have undergone temporal niche divergence. We found 200-700 differentially expressed genes, including day upregulation in eye development and visual processing genes, and night upregulation of antennal and olfactory brain development genes. Further, clusters of circadian, sensory, and brain development genes co-expressed with diel-activity. In both species, eight genes showed expression significantly correlated to diel activity, and are involved in vision, olfaction, brain development, neural plasticity, energy utilization, and cellular maintenance. We repeatedly recovereddisco, a zinc- finger transcription factor involved in antennal development, circadian activity, and optic lobe brain development in flies. Whilediscomutants have circadian arrhythmia, most studies attribute this to improper clock neuron development, not adult circadian maintenance. Comparing predicted 3D protein structure across moth and fly genetic models revealeddiscolikely retained developmental function with a conserved zinc finger domain, but gained functional zinc finger domains absent inD. melanogaster.These regions have several mutations between nocturnal and diurnal species that co- occur with higher levels of predicted phosphorylation sites. With robust circadian expression, functional nocturnal and diurnal mutations, and structural and sequence conservation, we hypothesize thatdiscomay be a master regulator contributing to diel-activity diversification in adult moths.SignificanceInsect diel-activity patterns are diverse, yet the underlying evolutionary processes are poorly understood. Light environment powerfully entrains circadian rhythms and drives diel-niche and sensory evolution. To investigate its impact, we compared gene expression in closely related day- and night-active wild silk moths, with otherwise similar ecologies. Expression patterns that varied with diel activity included genes linked to eye development, neural plasticity and cellular maintenance. Notably,disco, which encodes a zinc-finger transcription factor involved in pupalDrosophilaoptic lobe and antennal development, shows robust adult circadian mRNA cycling in moth heads, is highly conserved in moths, and has additional zinc-finger domains with specific nocturnal and diurnal mutations. We hypothesize thatdiscomay contribute to diversification of adult diel-activity patterns in moths.
Transforming customers into evangelists: influence of online brand experience on relationship quality and brand evangelism in the banking industry
Authors: Safeer Asif Ali , Le Thanh Tiep 
Published: May 2023

PurposeCustomer relationships and transforming customers into evangelists are imperative in today's world. Therefore, this study aimed to examine the influence of online brand experience (OBE) on brand evangelism (BEM) via relationship quality (trust-TRT, satisfaction-SAT, and commitment-CMT) by integrating the moderating effects of brand reputation (BR), particularly in the Vietnamese banking sector.Design/methodology/approachThis research obtained data from 486 Vietnamese customers who routinely used online banking services. The analysis was performed using structural equation modeling.FindingsThe findings demonstrate that OBE directly/indirectly positively affects BEM via relationship quality (TRT, SAT, CMT). Likewise, this study identified relationship quality (TRT, SAT, CMT) as an important mediator. Finally, the findings demonstrate that the moderation effects of BR significantly improved relationship quality (TRT, SAT, CMT) in the banking industry.Practical implicationsThis study showcases the significance of OBE in increasing brand evangelists in the financial sector. Thus, this study assists Vietnamese bank managers in creating new branding strategies to foster long-lasting customer relationships.Originality/valueThis original study contributes to the commitment-trust theory and signaling theory by examining the impact of the OBE on brand evangelism via relationship quality by considering the moderating effect of brand reputation in the Vietnamese banking sector.
Supply chain risk and SME business continuity strategies in the food industry during COVID-19 pandemic
Authors: Mohezar Suhana , Mohamad Marini Nurbanum , Mohd Nor Mohammad Nazri 
Published: May 2023

PurposeThis study aimed to (1) identify supply chain risks faced by small and medium-sized enterprises (SMEs) in food businesses during the COVID-19 pandemic and (2) investigate the business continuity management (BCM) strategies employed by organisations during the COVID-19 pandemic.Design/methodology/approachSemi-structured interviews were conducted, involving eight SMEs in the Malaysian food industry. Their responses were analysed using a thematic analysis.FindingsThe thematic analysis indicated that supply risks, demand risks, operational risks, logistics risks and financial risks were amongst the challenges that the respondents faced during the COVID-19 pandemic. It also provided evidence which showed the importance of flexibility, redundancy and collaboration to avoid or reduce the impact of such risks.Originality/valueThis paper fills the void in the literature by exploring the BCM practices amongst SMEs in the food businesses of a developing country, during the COVID-19 disruptions. Previous studies in the area had mainly focused on large organisations.
Female CEOs and default risk in listed family firms
Authors: Abinzano Isabel , Garcés-Galdeano Lucia , Martinez Beatriz 
Published: May 2023

Purpose
The purpose of this paper is to examine the effect of female CEO board members on listed family firms’ corporate default risk, integrating upper echelons theory with social role theory and the socio-emotional wealth approach and proxying default risk with the Black–Scholes–Merton model. It also searches for possible differences attributable to the type of female CEO.

Design/methodology/approach
This study is applied to a longitudinal sample of listed US family firms. After a preliminary analysis of the main descriptive, several models are estimated with the system GMM estimator, which is a panel data estimator. The models are dynamic, including the lagged value of the dependent variable. In addition, the model estimation is repeated with a different measure of default risk, for robustness.

Findings
This research findings show that default risk diminishes in the presence of a female CEO, whose reduction is even greater if she is a family member. The results are proven to be robust to the measure for proxying default risk.

Originality/value
This study primarily contributes to the existing literature by exploring a possible link between female CEOs, particularly those with a family affiliation, and a lower level of default risk in family firms. It also provides practical implications for policymakers, who would be advised to promote conditions enabling women to contribute towards family business viability. In addition, this study offers encouragement for family business owners to value the potential of their female family members in company succession processes.
The power of words: driving online consumer engagement in Fintech
Authors: ShabbirHusain R.V. , Pathak Atul Arun , Chandrasekaran Shabana , Annamalai Balamurugan 
Published: May 2023

PurposeThis study aims to explore the role of the linguistic style used in the brand-posted social media content on consumer engagement in the Fintech domain.Design/methodology/approachA total of 3,286 tweets (registering nearly 1.35 million impressions) published by 10 leading Fintech unicorns in India were extracted using the Twitter API. The Linguistic Inquiry and Word Count (LIWC) dictionary was used to analyse the linguistic characteristics of the shared tweets. Negative Binomial Regression (NBR) was used for testing the hypotheses.FindingsThis study finds that using drive words and cognitive language increases consumer engagement with Fintech messages via the central route of information processing. Further, affective words and conversational language drive consumer engagement through the peripheral route of information processing.Research limitations/implicationsThe study extends the literature on brand engagement by unveiling the effect of linguistic features used to design social media messages.Practical implicationsThe study provides guidance to social media marketers of Fintech brands regarding what content strategies best enhance consumer engagement. The linguistic style to improve online consumer engagement (OCE) is detailed.Originality/valueThe study’s findings contribute to the growing stream of Fintech literature by exploring the role of linguistic style on consumer engagement in social media communication. The study’s findings indicate the relevance of the dual processing mechanism of elaboration likelihood model (ELM) as an explanatory theory for evaluating consumer engagement with messages posted by Fintech brands.
Mainstream parties and global warming: What determines parties’ engagement in climate protection?
Authors: SCHWÖRER JAKOB 
Published: May 2023

AbstractGlobal warming is not only a serious threat for humanity but increasingly structures political competition in Western Europe. The rise of green (niche) parties and public awareness of the issue pressure mainstream parties to emphasise climate protection. Yet, while scholars reflect on the factors influencing mainstream parties’ environmental agendas, we know little about what triggers climate standpoints and about the role public opinion plays in this process. This study measures the salience of climate protection in 292 election manifestos of mainstream parties in 10 Western European countries since the 1990s and estimates the impact of different factors on their climate agenda using OLS regressions. The findings suggest that green parties are not the driving factor, and that it is the public salience of environmental issues and pressure from the Fridays for Future movement influencing mainstream parties’ agendas. Accordingly, mainstream parties seem to be responsive to public opinion pressure adopting climate protection stances. The study further proposes a different measure of niche party success than that used in previous studies.
Female leadership, internet use, and performance of agricultural cooperatives in Vietnam
Authors: Nguyen Trung Thanh , Do Manh Hung , Rahut Dil B. , Nguyen Viet Hung , Chhay Panharoth 
Published: May 2023

AbstractSupporting agricultural cooperatives might contribute to the livelihood improvement of many small‐scale farmers in developing countries. This research examines the factors affecting the internet use of agricultural cooperatives with a focus on female leadership, its effects on cooperatives’ economic, social, and innovative performance, and the distributional effects of internet use on economic performance. Our analysis relied on the data of 3,512 agricultural cooperatives collected in 2021 from Vietnam. We addressed the endogeneity issue of internet use in impact assessment by employing an instrumental variable approach. Our results show that female leadership was positively and significantly associated with internet use and that internet use had a positive and significant effect on returns on assets, returns on equity, labor productivity, payment per laborer, contribution to labor union and insurance per laborer, and innovation in products of agricultural cooperatives. In addition, unconditional quantile regressions show that internet use in agricultural cooperatives exacerbated income inequality. Enhancing female leadership and promoting rural education were recommended to improve agricultural cooperatives’ performance.
Outcomes of extended total mesorectal excision in patients with locally advanced rectal cancer
Authors: Saravanabavan Srivishnu , Kazi Mufaddal , Murugan Janesh , Vispute Tejas , Vijayakumaran Preeti , Desouza Ashwin , Saklani Avanish 
Published: May 2023

AbstractAimExtended total mesorectal excision (eTME) is a complex procedure involving en bloc resection of the structures surrounding the various quadrants of the rectum. This study, presenting the largest series so far of patients undergoing eTME, aimed to assess the surgical and survival outcomes of patients following treatment with eTME and to compare these outcomes with historical data on pelvic exenteration.MethodThe study is a retrospective review of all patients with locally advanced rectal cancer requiring an eTME (2014–2020). The database includes the demographic profile, operative details, histopathological features and follow‐up.ResultsOne hundred and sixty three patients who underwent eTME were analysed. The overall Clavien–Dindo complication rate of > IIIa was 21.1%. The anterior quadrant was the most common anatomical site resected (68.5%). The R1 resection rate was 10.4%. After a median follow‐up of 28 months, there were 51 recurrences in the study and twenty two deaths were recorded. The local recurrence rate was 7.3% among the study population. The disease‐free survival (DFS) and overall survival were 66.7% and 80.4%, respectively, at 3 years. The majority of the recurrences were distant metastasis (84.3%). In univariate analysis, the quadrant involved did not affect survival. In multivariate analysis, signet ring histology, metastatic presentation, inadequate tumour response and R1 resection affected DFS.ConclusionThe recurrence pattern, R1 resection rate and survival outcomes of patients in the present study were comparable with those for patients undergoing an exenteration. Therefore, eTME is probably a safe alternative to pelvic exenterations when R0 resection is achievable and when the procedure is performed in high‐volume specialist tertiary care centres.