bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH KINERJA KEUANGAN TERHADAP HARGA SAHAM (PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK) PERIODE 2019-2021
Authors: Mulyani Any Fitriya , Manunggal Syafrudin Arif Marah 
Published: June 2023

The purpose of this study was to test and analyze the effect of the Capital Adequency Ratio (CAR), Loan to Deposit Ratio (LDR), Return on Assets (ROA) and Debt to Equity Ratio (DER) on stock prices. The objects of this research are banking companies listed on the Indonesia Stock Exchange in 2019-2021. The population in this study were all banking companies listed on the Indonesia Stock Exchange, namely 106 banks. Determination of the sample using purposive sampling method, with a total sample of 25 banking companies that have certain criteria. The method used is panel data regression analysis with the help of the E-Views 12 application. The results of this study partially indicate that Return on Assets (ROA) loan to Deposit ratio (LDR) and Capital adequacy ratio (CAR) has a significant positive effect on stock prices. Meanwhile, Debt to Equity Ratio (DER) have no significant effect on stock prices on the Indonesia Stock Exchange (IDX) for the 2019-2021 period
Percutaneous steroid injection versus oral NSAIDs on treatment of symptomatic calcific rotator cuff tendinitis: a short-term retrospective clinical evaluation
Authors: HASSA Ercan 
Published: June 2023

Aim: Symptomatic calcific rotator cuff tendinopathies (CRCT) continue to be a significant health problem in the adult population because of intense pain and disability. Different clinical responses obtained with different treatment modalities show us the importance of determining the optimal method. The aim of this study is to compare short term pain and functional status improvements in adult patients diagnosed with CRCT and treated with oral non-steroid anti-inflammatory drugs (O-NSAID) or percutaneous steroid injections (PSI).
Material and Method: A retrospective examination was made of the clinical results of adult patients diagnosed with CRCT and treated with one of the two treatment methods. Whole study group was formed of 40 patients (20 male, 20 female) with a mean age of 42.35 ± 8.28 (range, 23-57) years. The clinical responses of the patients in a period of 3 months were compared between the two treatment groups O-NSAID, PSI using the Visual Analogue Scale (VAS) and the Quick Disability of the Arm, Shoulder, and Hand Scale (Q-DASH). The angular upper limit values of the active range of motion (ROM) of the shoulder joint (anteflexion and abduction angle) of patients also were compared in the study.
Results: In the PSI treatment group, in the 3rd week and 3rd month clinical evaluations, significant better responses were obtained in both the VAS and Q-DASH scores of the patients compared to O-NSAID treatment group (p=0.000, p=0.001, respectively). And significant greater shoulder anteflexion and abduction ROM upper limits were determined in the PSI treament group compared to O-NSAID treatment group at the end of the 3rd month (p=0.000, p=0.000, respectively).
Conclusion: The percutaneous steroid applications in treatment of CRCT can provide more pleasing short term results than O-NSAID treatments in terms of pain reduction and functional improvement.
Parkinson’s Disease Drug Therapies in the Clinical Trial Pipeline: 2023 Update
Authors: McFarthing Kevin , Buff Susan , Rafaloff Gary , Fiske Brian , Mursaleen Leah , Fuest Rosie , Wyse Richard K. , Stott Simon R.W. 
Published: June 2023

Background: Since 2020, annual reports on the clinical development of new drug-based therapies for the neurodegenerative condition of Parkinson’s disease (PD) have been generated. These reviews have followed the progress of both “symptomatic treatments” (ST – improves/reduces symptoms of the condition) and “disease modifying treatments” (DMT - attempts to delay/slow progression by addressing the underlying biology of PD). Additional efforts have been made to further categorize these experimental treatments based on their mechanisms of action and class of drug. Methods: A dataset of clinical trials for drug therapies in PD was obtained using trial data downloaded from the ClinicalTrials.gov online registry. A breakdown analysis of all the studies that were active as of January 31st, 2023, was conducted. Results: There was a total of 139 clinical trials registered on the ClinicalTrials.gov website as active (with 35 trials newly registered since our last report). Of these trials, 76 (55%) were considered ST and 63 (45%) were designated DMT. Similar to previous years, approximately a third of the studies were in Phase 1 ( n = 47; 34%), half ( n = 72, 52%) were in Phase 2 and there were 20 (14%) studies in Phase 3. Novel therapies again represented the most dominant group of experimental treatments in this year’s report with 58 (42%) trials testing new agents. Repurposed drugs are present in a third ( n = 49, 35%) of trials, with reformulations and new claims representing 19% and 4% of studies, respectively. Conclusions: Our fourth annual review of active clinical trials evaluating ST and DMT therapeutics for PD demonstrates that the drug development pipeline is dynamic and evolving. The slow progress and lack of agents transitioning from Phase 2 to Phase 3 is concerning, but collective efforts by various stakeholders are being made to accelerate the clinical trial process, with the aim of bringing new therapies to the PD community sooner.
Use of milk samples in epizootic surveillance of cattle diseases
Authors: Mishchenko A. V. , Gulyukin A. M. , Oganesyan A. S. , Mishchenko V. A. , Gulyukin M. I. , Lopunov S. V. , Zabolotnaya I. M. 
Published: June 2023

Relevance. The analysis of the possibility of using milk as a non-invasive type of samples in the epizootological control of diseases of cattle is given. During pathogenesis, many etiologic agents cause breast lesions or are excreted together with milk, which makes milk an ideal sample for laboratory diagnostics of infectious diseases of cattle, since it is available in any quantity and its samples are easy to collect.Methods. Conventional methods of document analysis were used.Results. It is shown that milk samples can be used both at the individual and at the population level for early identification of infected herds, screening of infected herds and use to obtain evidence of the well-being of herds. The availability of commercial diagnostic test systems for detecting antibodies in milk to the causative agents of leukemia of cattle, viral diarrhea of cattle, Brucella abortus, Mycobacterium avium subspecies paratuberculosis, Fasciola hepatica, Q fever (Coxiella burnetii) makes available programs for the control and eradication of diseases in dairy herds and at the level of countries. The use of combined non-invasive milk samples makes it possible to combat slowly progressive and chronic cattle infections of dairy cattle (bovine leucosis, paratuberculosis, brucellosis), and exclude carrier animals from the production chain in real time, which indicates the feasibility of introducing this type of samples into veterinary practice in the Russian Federation.
The influence of inert fats on the processes of digestion and intensity of milking of highly productive cows
Authors: Golovin A. V. , Tsarev E. A. 
Published: June 2023

Relevance. It is known that highly productive cows in the first third of lactation experience an increased need for energy. One of the effective ways to increase the energy saturation of diets is the use of protected fats in their feeding.Methods. The effect of hydrogenated and fractionated fats (GC «EFKO», Russia) on the processes of rumen metabolism, the digestibility of dietary nutrients and the intensity of milking of highly productive cows, when used in the period from 21 to 120 days of lactation, was studied in an experiment conducted in an experimental farm «Klenovo-Chegodaevo» (Moscow) on three groups of dairy cows of the holsteinized black-and-white breed with a milk yield of 7000 kg of milk for the previous lactation, 10 animals each.Results. In physiological studies, it was found that the feeding of protected fats did not have a negative effect on the processes of rumen metabolism and had a positive effect on the trend of better digestion of dietary nutrients by animals of I and II experimental groups compared to the control, with an increase in the digestibility of crude fat by 2.7–3.1 abs. % (p < 0.05). Accounting for milk productivity showed that the inclusion of inert fats in the diets of cows of the experimental groups in the amount of 300 g/head/day, in order to increase the concentration of metabolic energy from 10.7 to 11.0 MJ per 1 kg of dry matter, contributed to an increase in milk yield 4% fat content for 120 days of lactation by 8.1–9.4% (p < 0.05), compared with the control, feed costs, expressed in ME, decreased by 5.3%. At the same time, in the milk of cows fed fractionated fat, an increase in the mass fraction of palmitic acid by 2.29 abs. % (p < 0.05), compared with the control. In general, for 305 days of lactation, the gross milk yield of 4% fat in cows of the experimental groups exceeded the control by 6.2–7.3% (p ≥ 0.05), with a decrease in feed costs (ME) by 4.8%.
Technological properties of milk of cows with different proportion of blood in the Holstein breed
Authors: Gorelik A. S. , Rebezov M. B. , Gorelik O. V. 
Published: June 2023

Relevance. The priority task for the agro-industrial complex of Russia is to provide the population of the country with high-grade products. One of these products is milk. It is not only a valuable food product, but also a raw material for the dairy industry, its use for the production of certain products is determined by its technological properties. The study of these properties in a new genetic formation of dairy cattle in the Middle Urals zone has both scientific and practical interest.Results. As a result of the research, it was found that the milk obtained from cows with a Holstein breed genotype (75–91%) was the best in terms of the content of dry matter and its components. Cowʼs milk, regardless of genotype, is suitable for the production of highly processed products — canned milk and cheeses. According to all indicators, milk, with the exception of cows of the group with a genotype of 97% or more in terms of the ratio of protein and SOMO, is suitable for making cheese. Lower rates of suitability of milk for processing into Adyghe cheese were observed in milk from cows with a Holstein genotype of more than 91%. To improve the clot, the use of rennet was proposed, which made it possible to reduce the cost of calcium chloride and obtain a denser clot. The use of new technological solutions in the manufacture of Adyghe cheese with the use of protein coagulators makes it possible to increase the degree of use of fat and protein from cowʼs milk and reduce the cost of milk for its production.
Influence of probiotics on growth dynamics and blood parameters of Zaanen goats
Authors: Safina A. K. , Hoggui M. A. , Gainullina M. K. , Krupin E. O. 
Published: June 2023

Relevance. In the prevention and treatment of gastrointestinal diseases in the rearing of young animals, the restoration of intestinal biocenosis with the use of probiotics — bacterial preparations from live microbial cultures is of great importance.The purpose of the research is to study the effect of probiotic feed additives Klyuver Pro and BeneFIT Basic on growth dynamics, feed costs and blood parameters of Saanen goats.Methods. The studies were carried out at LLC «Lukoz Saba» of the Sabinsky district of the Republic of Tatarstan. The object of the study is the kids of the Saanen breed at the age of seven days. Scientific and economic experience was carried out according to the method of analogues. The chemical composition and nutritional value of feed, the dynamics of changes in live weight, the morphological and biochemical parameters of the blood of goats were studied. Statistical data processing was carried out using Microsoft Excel. A difference of p ≥ 0.05 was considered significant.Results. Probiotic feed additives Kluver Pro and BeneFIT Basic activate metabolic processes in the body of kids, increase the digestibility and assimilation of feed, which has a positive effect on the growth and development of animals, and reduce feed costs. The live weight of goats treated with probiotics increased (compared with the control) by 7.7% (p ≥ 0.05) and 3.6%. Feed costs decreased per 1 kg of live weight gain decreased by 13.6% and 10.1%.In the blood of animals treated with probiotics, there was an increase in hematocrit, hemoglobin and erythrocytes. In animals of the second group, these indicators increased by 17.4%, 31.7 g/l (39.3%) (p ≥ 0.001) and 4.45 ˟ 1012/l (77.1%) (p ≥ 0.001), in animals the third group — respectively, by 7.5%, 7.7 g / l (9.5%) (p ≥ 0.001) and 1.63 ˟ 1012/l (28.2%), as well as a significant decrease in ESR — by 0, 37 mm/g and 0.18 mm/g (p ≥ 0.001), calcium content by 20% and 24.2% (p ≥ 0.05).
The results of studies of the influence of temperature and density on the stability of marshmallow
Authors: Dolmatova I. A. , Zaitseva T. N. , Kuznetsova E. A. , Issayeva K. S. 
Published: June 2023

Relevance. The quality of products tends to be a core indicator of any enterprise activity defining its competitiveness within market conditions to a great extent. Production of confectionery creams avoiding usage of stabilizers, preservatives and trans fats is a promising direction being demanded by consumers. Stability of the whipped mass within production and storage processes depends on the dynamics of the confectionery foam destruction, which leads to degradation of whipped products form and volume. Stability and dimensional stability of foam systems become key indicators of food products quality reflecting their major structural and mechanical properties.Methods. This article studies dependence of the stability (incl. dimensional stability) of cream marshmallow on temperature and density. Through experimental path authors show influence of molasses temperature set in line with recipe on the whipped cream density.Results. Molasses temperature determines the temperature denaturation of egg whites, their bond and forms a stable structure. The study of cream marshmallow samples obtained from molasses with a density of 1.3 g/cm3, 0.9 g/cm3 and 0.7 g/cm3 established that lower density of molasses added in line with the recipe forms a stronger and more stable structure of cream marshmallow.
The Virtual Capriccio: The Semiotics of Architecture in Digital Games
Authors: Aroni Gabriele 
Published: June 2023

<p>Digital games are among the most popular media on the planet, and billions of people inhabit such virtual worlds daily. Most of these worlds are made of virtual buildings, roads, and cities that players travel through. This dissertation aims to fill a gap in the game studies literature regarding the architecture of digital games, in terms of both its aesthetic aspect and its symbolic role as they relate to gameplay. It strives to answer the following questions: how does the design of virtual architecture influence gameplay and storytelling through its communicative aspect? How does digital architecture relate to real architecture? Where does the inspiration for digital games architecture come from? </p>
<p>In order to answer these questions, this dissertation examines how architecture is used in digital games, how players interact with it, and what it communicates. The dissertation thus analyses the architecture of digital games through the lenses of semiotics and architecture theory, mainly the research pursued by Umberto Eco as regards the semiotics of architecture and by Brian Upton with his theory of “anticipatory play.” It presents case studies of digital games grouped in three categories: reconstructive, fantastic, and visionary. Reconstructive virtual architecture, as evidenced in <em>Assassin’s Creed II</em> (2009), aims to recreate existing locales, be they from the present or the past, with the intent to immerse the player in a simulated environment that is as close as possible to reality. Fantastic virtual architecture, represented by the Japanese game <em>Final Fantasy XV</em> (2016), is the category that arguably encompasses the vastest number of digital games, as it comprises the type of architecture designed to appear, if not realistic, at least plausible, and bears resemblance to real-world architecture. Finally, the category of visionary virtual architecture, as found in the independent game <em>NaissanceE</em> (2014), while still representing plausible and not completely abstract features, is meant to be perceived as an “impossible” construct. Through these case studies, the dissertation outlines how architecture plays a central role in digital games design, and proposes a semiotic framework for the analysis of virtual architecture that can be applied to the vast majority of digital games.</p>
Mediated Landscapes: Technology and Environment in Recent Canadian Cinema
Authors: Browne Daniel 
Published: June 2023

<p>A central defining feature of the contemporary era is an environmental crisis that has been triggered by the relationship of human-developed technologies to the natural world, which is leading us towards conditions of increasing collapse that will impact all future understandings of our era’s cultural production and experience. This crisis has led many to propose that the planet has entered a new geologic epoch, the “Anthropocene,” in which boundaries between humanity, nature, and technology have become blurred and no longer viable. In this dissertation, I explore this ecological crisis as a manifestation of mythological and perceptual frameworks that structure contemporary modes of experience, by examining how Canadian filmmakers are responding to such conditions through their artworks. Drawing on Marshall McLuhan’s notion of art as a “counter-environment” that, in its most potent capacity, acts as a “liaison between biology and technology” ([1973] 2003a, 207) or “Distant Early Warning system,” I explore how many recent Canadian films prioritize process, hybridity, decay, and transmutation to reveal the environmental status of media, developing new myths and metaphors that address the crisis of imagination that I argue is at the root of the environmental crisis. Through these approaches, the binaries between humanity, technology, and nature are revealed as false dualisms that have always been united within a greater ecological matrix—an insight that reflects the holistic study of media developed by the Toronto School of Communication. </p>
<p>The environmental crisis cannot be resolved through any singular response, but rather necessitates a proliferation of new forms of critical thought, empathy, and modes of experience. Accordingly, in this study I explore a range of aesthetic approaches to interrogate forms of critical visuality in cinema that articulate the environmental invisibility of media, including narrative, documentary, and experimental works. These examples are united by a framework that seeks to cultivate perceptual sensitivities through revelatory forms over discursive approaches. By revealing the strong affinities between Canadian art and critical theory, I demonstrate how cinema can provide a fertile terrain for critiquing technological environments and their influence upon notions of embodiment, the natural world, and the shaping force of language.</p>
The Post-Digital Pensive Image: Reclamation of Subjectivity within Communicative Capitalism
Authors: Rooney Cody 
Published: June 2023

<p>This paper/project theorizes an epistemological rupture between the scopic regimes of Cartesian Perspectivalism and the “Post-Digital” and how these influence conceptions of reality, identity, and subjectivity. Through an analysis of the progression of perspectivalism from the 15th century to the digital image, the photograph is theorized as operating concomitantly with realism and positivism, and through digital mediation, as having been commodified and weaponized by capitalism for the purposes of subjugating its subject. This subjugation is theorized as producing a pervasive dysphoria, as the simulacrum of reality engendered by digital visuality causes the semiology of reality to dissolve. The “post-digital,” then, serves as a negation of this subjugation through a reflexive and hyper-mediated visuality that employs surrealist strategies to ground the spectator in their own subjectivity. The photographic component is an inquiry into how I, as a digital subject, utilize aesthetic strategies in order to ground my own subjectivity within this paradigm. </p>
Making up a Drug Epidemic: Constructing Drug Discourse during the Opioid Epidemic in Ontario
Authors: Sidak Travis 
Published: June 2023

<p>The current opioid epidemic has resulted in growing rates of overdose across the province with the introduction of fentanyl into illicit drug markets. What barriers are preventing policy makers from enacting emergency measures to save lives and how have those affected by the epidemic been categorically ignored? The following research critically analyzes drug discourse relating to the current opioid epidemic in Ontario and discusses why government responses to the epidemic have been delayed, and why they offer inferior measures to prevent growing mortality and morbidity. Using Ian Hacking’s theory of dynamic nominalism, the work systematically deconstructs drug discourse through a number of perspectives in order to identify stakeholders and manifest relations of power that drive policy deliberation and designate key figures of authority. Research has shown that opioid dependent users are infantilized and demonized due to a history of negative perspectives on drug use that persist today in drug discourse. </p>
Institucionalizar la memoria, enseñar el amor a la patria: la Academia de la Historia de Cartagena y la construcción del pasado, 1911-1930
Authors: Arrieta Cerro Aida 
Published: June 2023

En 1911, en el marco del primer centenario de la Independencia de Cartagena, se creó un centro de historia como filial de la Academia Nacional de Historia. En este artículo, teniendo en cuenta el papel de estas academias como modeladoras del pasado, estudiamos el papel desempeñado por la Academia de la Historia de Cartagena en la construcción de una memoria local y el tipo de pasado histórico que ayudó a configurar entre 1911 y 1930. A través de una revisión sistemática de su principal publicación (Boletín Historial), junto a la revisión de prensa que circuló en Cartagena durante el período en estudio, mostramos que- a través de la reproducción de documentos históricos- contribuyó a difundir y cimentar una memoria histórica local y nacional. La publicación de artículos –centrados principalmente en héroes, grandes batallas y conmemoración de fechas fundacionales- fueron centrales en la reconstrucción de un pasado heroico y en la difusión de sucesos a través de los cuales se buscó fortalecer el amor por la patria.