bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learnings from Implementation Strategies to Improve Lipid Management
Authors: Lan Nick S. R. , Chen Ruofei Trophy , Dwivedi Girish , Watts Gerald F. , Nicholls Stephen J. , Nelson Adam J. 
Published: January 2025

Abstract
Purpose of Review
Lowering low-density lipoprotein (LDL)-cholesterol reduces cardiovascular risk. International lipid management guidelines recommend LDL-cholesterol goals or thresholds for initiating lipid-lowering therapy. However, contemporary real-world studies have shown that many high- and very high-risk patients are not attaining LDL-cholesterol goals and are not receiving intensive lipid-lowering therapies. In this review, recent examples of implementation strategies for optimising lipid management are discussed.

Recent Findings
Implementation studies are heterogenous in their strategies and design. At the clinician level, multidisciplinary team-based care (including multidisciplinary lipid clinics), pharmacist- or nurse-led interventions, decision-support algorithms or protocols, and educational initiatives have shown potential to improve lipid management. Various strategies to improve patient adherence to lipid-lowering therapies have demonstrated at least short-term efficacy, including education, shared decision-making, behavioural support and nudges. Electronic health records can be leveraged at low cost to identify patients requiring initiation or intensification of lipid-lowering therapies, but the optimal method of integrating automated alerts or nudges to influence decision-making requires further research. Moreover, telehealth and remote care delivery models can improve access to healthcare and facilitate lipid-lowering.

Summary
Multifaceted strategies with a systematic approach to targeting clinician, patient and system related factors can be successful in improving lipid management. Future implementation research should evaluate longer-term outcomes and follow implementation science theories, models and/or frameworks at all stages. By doing so, ongoing implementation studies will help researchers better understand the impact, sustainability and scalability of strategies, and where barriers and facilitators to lipid management may exist in other contexts.
Diagnosis and Management of Mild Traumatic Brain Injury (mTBI): A Comprehensive, Patient-centered Approach
Authors: Sergeyenko Yevgeniya , Andreae Mollie E. , Segal Miriam 
Published: January 2025

Abstract
Purpose of Review
The purpose of this review is to provide an update regarding recent research and recommendations in the care of mild traumatic brain injury (mTBI).

Recent Findings
New diagnostic criteria for mTBI have recently been developed by the American Congress of Rehabilitation Medicine through the Delphi method and this will help to standardize assessment, diagnosis, and treatment.

Summary
Symptoms of mTBI are diverse and can sometimes become persistent. Treatment of mTBI should be patient-centered and may require subspeciality referral and coordinated, inter-disciplinary, or multi-disciplinary treatment.
Management Strategies for the Anti-nutrient Oxalic Acid in Foods: A Comprehensive Overview of Its Dietary Sources, Roles, Metabolism, and Processing
Authors: Zayed Ahmed , Adly Ghada M. , Farag Mohamed A. 
Published: January 2025

AbstractOxalic acid is among the most abundant organic acids found in different biospheres, including plants, as an end product of metabolism. It forms either soluble or insoluble salts with monovalent or divalent cations, respectively. Then, consumption of oxalic acid-rich foods in human diets, particularly leafy vegetables (e.g., spinach, tea, and rhubarb), affects minerals absorption such as calcium. Meanwhile, its high level in blood is associated with many diseases such as hyperoxaluria systemic oxalosis and is thus classified among potential anti-nutrients. Various factors have affected oxalic acid levels in foods, including agricultural traits and consumption practices. Hence, the current review aimed at rediscovering oxalic acid dietary sources, metabolism, and the various processes employed to reduce its content in foods, and consequently, health harmful effects. Among them are physical/cooking, chemical, fermentation, and biotechnological processing. Recent biotechnological approaches have been attempted to produce transgenic crops remodeling oxalate metabolism, particularly its degradation. The soluble form of oxalate seems to be better absorbed and more harmful than insoluble salts in foods aiding in kidney stones formation. Cooking (e.g., boiling, microwaving, and steaming) appears as a useful management strategy to reduce soluble oxalate and, therefore, lowering oxaluria. The present review provides new perspectives on different processing methods to lower oxalate in essential vegetables highlighting their advantages or any limitations to aid improve these foods nutritional value and consumption.
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study
Authors: Merzel Šabović Eva Klara , Kraner Šumenjak Tadeja , Božič Mijovski Mojca , Janić Miodrag 
Published: January 2025

AbstractPsoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantly to increased cardiovascular risk. While various treatments completely clear the skin, the associated effects on systemic inflammation are not yet clear. We investigated residual systemic inflammation in successfully treated patients. Circulating disease-specific and non-specific inflammatory markers were measured and compared in 80 psoriasis patients (aged 30–45 years) successfully treated with topical therapy, methotrexate, adalimumab, secukinumab or guselkumab, and in 20 healthy controls. Non-specific inflammatory markers (high-sensitivity C-reactive protein (hs-CRP), complete blood count (CBC) parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet ratio (MPR), and red blood cell distribution width-to-platelet ratio (RPR)) and disease-specific inflammatory markers (interferon-γ (IFN-γ), tumor necrosis factor (TNF), interleukin (IL)-1β, IL-12p70, IL-17, and IL-23) were measured and compared between groups. Disease-specific cytokines (IFN-γ, TNF, IL-1β, IL-12p70, and IL-17, but not IL-23), were significantly elevated in patients compared to controls, while non-specific inflammatory markers showed no differences compared to controls. The residual disease-specific cytokines were similarly elevated in all five treated groups. In addition, they correlated significantly with body mass index (BMI) and waist circumference. Our results suggest that psoriasis patients have elevated residual disease-specific cytokines despite successful treatment, while the non-specific inflammatory markers are similar to those in control subjects. Residual disease-specific inflammatory markers correlated with BMI and waist circumference. A possible beneficial effect of body weight control in psoriasis patients merits further investigation. The study was registered at http://clinicaltrials.gov (identifier: NCT05957120) on July 24, 2023.
Replication Crisis in Psychology, Second-Order Cybernetics, and Transactional Causality: from Experimental Psychology to Applied Psychological Practice
Authors: Brailas Alexios 
Published: January 2025

AbstractThis article aims to reconceptualize the replication crisis as not merely a problem of flawed methods, lack of scientific rigor, or questionable researcher conduct, but as a fundamentally epistemological and philosophical issue. While improved methodologies and scientific practices are necessary, they must be considered through the lens of the underlying epistemologies. Toward this end, a new paradigm for psychological research and practice, grounded in second-order cybernetics and transactional causality, is proposed as instrumental. Second-order cybernetics, as introduced by Heinz von Foerster, challenges traditional scientific methodologies that assume a strict separation between the observer and the observed. The core idea is that the observer, through the very act of observing, inevitably becomes part of the system they study, leading to a shift from linear to transactional causality. This epistemological shift has profound implications for the research practice and the responsibility of the psychology practitioner. Foerster’s ethical imperative –act always so as to increase the number of choices– combined with the aesthetic imperative –If you desire to see, learn how to act– illuminates an alternative methodological landscape for the clinical practice. The replication crisis in psychology is examined in light of these theoretical shifts, allowing for a new constructive vision which integrates basic research with applied psychological practice. Second-order cybernetics encourages a participatory approach to research, emphasizing the catalyzing role of the observing practitioner. The article concludes by advocating for an epistemological superposition, where psychologists navigate multiple perspectives to enhance the integrity and applicability of their findings in the real world.
Transforming managers with mindfulness-based training: a journey towards humanistic management principles
Authors: Yavuz Sercekman Meltem , Akca Meltem 
Published: January 2025

AbstractThis study examines the transformative impact of a 6-week mindfulness-based training program on managers within the framework of humanistic management principles. Implemented as a randomized controlled trial (RCT), the research involved 97 managers from the R&D department of a technology development company in Turkiye. Participants were allocated to either an intervention group (N = 47) or a waitlist control group (N = 50), with assessments conducted at three time points: pre-test, post-test, and a 16-week follow-up. The findings reveal significant improvements in empathy, mindfulness, and wisdom among managers who completed the program, compared to those who did not. While the impact on inclusive leadership was less pronounced, the results indicate potential benefits for organizational culture as a whole. This study provides empirical evidence supporting the efficacy of mindfulness-based interventions in fostering key elements of humanistic management—such as empathy, mindfulness, and wisdom—and underscores their broader implications for cultivating a more humanistically oriented workplace.
A qualitative Exploration of Contextual Factors Within Schools Impacting the Introduction of the New Statutory ‘Framework on Embedding a Whole School Approach to Emotional and Mental Wellbeing’ in Wales
Authors: Brown Rachel , Anthony Rebecca , Eyre Olga , Lennon Jessica , Powell Vicky , Haslam Zoe , Rowe Abbey , Moore Graham 
Published: January 2025

AbstractIn 2021, the Welsh Government introduced new statutory guidance for schools titled ‘Framework Guidance on Embedding a Whole School Approach to Emotional and Mental Wellbeing’. This document outlined new responsibilities for educational settings to work towards incorporating a whole school approach, with regard to the Framework in action planning, service delivery and policy in relation to the mental and emotional wellbeing of learners and staff. While there is growing evidence to suggest that whole school approaches can be beneficial to social and emotional wellbeing for pupils, evidence on effective implementation is limited. This paper reports on findings from qualitative group interviews with staff in schools in Wales, conducted as part of a wider, mixed-methods evaluation of the Framework. It focuses on factors in the school context which impacted initial implementation. A number of school level factors were identified as barriers to implementation and staff engagement with the Framework. School staff reported higher levels of pupil mental health challenges stemming from the COVID-19 pandemic and an absence of capacity in in-house and external support services to address this. Poor staff wellbeing and significant workload pressures were also reported, driven in part by concurrent implementation of the new Curriculum For Wales. This led staff to feel ill-prepared for the more complex issues being faced, exacerbated by a lack of access to relevant training to be able to support pupil and colleague mental health. This paper concludes with recommendations for policy-makers to support Framework implementation.
Energy-Efficient Synthesis of Copper Terephthalate Metal–Organic Frameworks Using Sorbitol and Choline Chloride-Based Deep Eutectic Solvents for Methylene Blue Removal
Authors: Yılmaz Mertsoy Esra 
Published: January 2025

Abstract
Metal–organic frameworks (MOFs) are considered promising candidates for organic pollutant remediation due to their adaptable topology, large surface area, porous structure and unsaturated metal sites. This study presents a novel, safe, environmentally friendly and energy-efficient method for synthesizing copper terephthalate metal–organic frameworks (Cu-BDC). The synthesis utilizes choline chloride/sorbitol deep eutectic solvent (DES), a green solvent, which allows for milder synthesis conditions. The use of DES in Cu-BDC synthesis was calculated to provide up to 99% energy savings compared to traditional method, showcasing the energy efficiency of this approach. Methylene blue (MB) adsorption using the synthesized samples was investigated. MB was selected as a model molecule because of its toxicity and persistence in the aquatic environment. Compared to Cu-BDC, Cu-BDC-D (synthesized form in DES) showed greater effectiveness in adsorption of MB with 98.7% removal at 10 g/L catalyst dosage, pH 7, 100 mg/L MB initial concentration and at 25 °C. The effects of various parameters, including adsorbent dosage, pH and temperature, on adsorption capacity were examined. The kinetic data were analyzed using both pseudo-first-order and pseudo-second-order kinetic models. The results indicated that the adsorption kinetics followed the pseudo-second-order model, and the Weber and Morris intraparticle diffusion model and Chrastil diffusion models were employed to further investigate the diffusion processes involved in adsorption. Additionally, the Langmuir, Freundlich and Sips isotherm models were analyzed, with the Langmuir isotherm providing the best fit. Desorption experiments demonstrated that the adsorbent could be reused up to three times. This study highlights the potential of MOF obtained in DES as an effective and sustainable adsorbent for dye removal in water treatment applications.
Elastic Residual Strain Measurements of 3D Additively Manufactured Builds of Nickel Alloy 718 AM Bench 2022 Artifacts Using Energy Dispersive Synchrotron X-ray Diffraction
Authors: Phan Thien , Șeren Hazar , Das Amlan , Ko Peter , Nygren Kelly , Levine Lyle 
Published: January 2025

AbstractResidual elastic strains and the resulting stresses are key aspects of most metal additive manufacturing (AM) approaches and strongly affect both the build process and part performance. Computational modeling of these stresses allows the manufacturer to compensate for the distortions that occur during the build process and to predict where part failures may occur. Such simulations must be validated against rigorous measurement datasets. Here, energy dispersive synchrotron X-ray diffraction is used to characterize the location-specific elastic strains within additively manufactured laser powder bed fusion (PBF-LB) nickel Alloy 718 test artifacts. Elastic strains are measured along two orthogonal directions from 2248 measurement locations and the measurement uncertainties are assessed. Comparisons are made between the measurement results and modeling predictions submitted by the AM modeling community. These measurements are part of the Additive Manufacturing Benchmark Test Series (AM Bench), a broad effort to produce measurement datasets for validating AM computer simulations across the range of processing, structure, and properties, for many AM build methods and material classes. All the measurement data are available online with download links at www.nist.gov/ambench.
Bioethanol production from concentration fruit wastes juice using bakery yeast
Authors: Mtashobya Lewis Atugonza , Mgeni Shedrack Thomas , Emmanuel Jovine Kamuhabwa 
Published: January 2025

AbstractAppropriate and effective management of fruit wastes is fundamental for promoting sustainability, minimizing environmental impacts, and safeguarding human health. This underscores the necessity for sustainable waste management practices including transforming them into valuable products to mitigate their adverse effects. This study focuses on the production of bioethanol from pineapple, mango, watermelon, and pawpaw fruit wastes juice through yeast fermentation and controlled distillation. The juice from a mixture of fruit wastes was enriched with 200 g of bakery yeast to facilitate the fermentation process. Results show that bioethanol from fruit waste juice mixture with bakery yeast produced bioethanol with alcohol content of 30%, while the fruit waste juice mixture without yeast had 20%. The bioethanol from the initial distillation was combined and re-distilled to improve the quality of bioethanol from 12 to 30% to an impressive alcohol content of 88%. The bioethanol production from fruit wastes, achieved through bakery yeast fermentation and distillation, demonstrated promising outcomes and potential use as bioenergy and its contribution to environmental conservation. Future research may focus on enhancing yeast-fruit waste juice ratio and utilizing enzymes to expedite carbohydrate breakdown.
Fibre: The Forgotten Carbohydrate in Sports Nutrition Recommendations
Authors: Mancin Laura , Burke Louise M. , Rollo Ian 
Published: January 2025

AbstractAlthough dietary guidelines concerning carbohydrate intake for athletes are well established, these do not include recommendations for daily fibre intake. However, there are many scenarios in sports nutrition in which common practice involves the manipulation of fibre intake to address gastrointestinal comfort around exercise, or acute or chronic goals around the management of body mass or composition. The effect of fibre intake in overall health is also important, particularly in combination with other dietary considerations such as the elevated protein requirements in this population. An athlete’s habitual intake of dietary fibre should be assessed. If less than 20 g a day, athletes may consider dietary interventions to gradually increase intake. It is proposed that a ramp phase is adopted to gradually increase fibre ingestion to ~ 30 g of fibre a day (which includes ~ 2 g of beta-glucan) over a duration of 6 weeks. The outcomes of achieving a daily fibre intake are to help preserve athlete gut microbiome diversity and stability, intestinal barrier function as well as the downstream effects of short-chain fatty acids produced following the fermentation of microbiome accessible carbohydrates. Nevertheless, there are scenarios in which daily manipulation of fibre intake, either to reduce or increase intake, may be valuable in assisting the athlete to maintain gastrointestinal comfort during exercise or to contribute to body mass/composition goals. Although further research is required, the aim of this current opinion paper is to ensure that fibre is not forgotten as a nutrient in the athlete’s diet.
Enhancing COVID-19 Vaccine Acceptance Within Scotland Black, African, and Caribbean Communities and Lessons for Future Vaccination Programmes
Authors: Adekola J. , Audu J. G. , Okey-Adibe T. , Abubakar A. , Lance M. , Blaize C. , Miragoli M. 
Published: January 2025

AbstractThis study highlights how the intersection of multiple factors shapes the experiences of Scotland’s Black, African, and Caribbean communities in their access and uptake of COVID-19 vaccines in the vaccination programme’s first, second, and booster stages. There was particular interest in understanding the vaccination journey, from scheduling an appointment to attending the appointment. Data in this study was collected between the 1 and 30 April 2022 using a triangulated approach, including a survey (with 408 responses), interviews (26), and focus group discussions (5 groups involving 30 participants). The study shows that 62% of respondents found scheduling a COVID-19 appointment easy, with less than 1% of respondents indicating that the process was complex. Online booking, appointment letters, and walk-in appointments were the most common ways of securing vaccination appointments. Letter appointments, specifically the blue envelope, were beneficial reminder mechanisms. It also provided information about COVID-19 vaccines and what to expect when attending the appointments. Other forms of securing vaccination appointments, such as through GP surgeries, were less commonly used. Around 21.5% of participants felt that receiving an appointment letter provided useful pre-vaccination information and a helpful reminder for their appointment. The accessibility of the vaccination centre, professionalism of the staff, and friendly approach enhanced the vaccine user access, use, and experience of COVID-19 vaccination.
Local Strain Engineering of Two-Dimensional Transition Metal Dichalcogenides Towards Quantum Emitters
Authors: Ai Ruoqi , Cui Ximin , Li Yang , Zhuo Xiaolu 
Published: January 2025

AbstractTwo-dimensional transition metal dichalcogenides (2D TMDCs) have received considerable attention in local strain engineering due to their extraordinary mechanical flexibility, electonic structure, and optical properties. The strain-induced out-of-plane deformations in 2D TMDCs lead to diverse excitonic behaviors and versatile modulations in optical properties, paving the way for the development of advanced quantum technologies, flexible optoelectronic materials, and straintronic devices. Research on local strain engineering on 2D TMDCs has been delved into fabrication techniques, electronic state variations, and quantum optical applications. This review begins by summarizing the state-of-the-art methods for introducing local strain into 2D TMDCs, followed by an exploration of the impact of local strain engineering on optical properties. The intriguing phenomena resulting from local strain, such as exciton funnelling and anti-funnelling, are also discussed. We then shift the focus to the application of locally strained 2D TMDCs as quantum emitters, with various strategies outlined for modulating the properties of TMDC-based quantum emitters. Finally, we discuss the remaining questions in this field and provide an outlook on the future of local strain engineering on 2D TMDCs.