bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of combined decitabine and ruxolitinib in the treatment of chronic myelomonocytic leukemia*
Authors: Li Jiaming , Zhang Sujiang , Chen Yubao , Yan Zeying , Wang Ying , Liu Zhiyin , Sun Haimin , Chen Yu 
Published: June 2023

Abstract

Objective
The aim of the study was to evaluate the clinical efficacy of decitabine (DEC) combined with ruxolitinib (RUX) in the treatment of chronic myelomonocytic leukemia (CMML).

Methods
The clinical characteristics of 12 patients with CMML were analyzed retrospectively and subsequent target sequencing was performed to investigate the efficacy of the combined treatment with DEC and RUX and the molecular signatures therein.

Results
Among the 12 cases, clinical improvement was observed in all patients (100%), spleen reduction was observed in six patients (67%), and hematologic improvement was observed in four patients (33%). In the CMML-1 group, the overall response was 50% (3/6), one case achieved complete response, one achieved bone marrow remission, and one achieved hematological improvement. In the CMML-2 group, the overall response was 17% (1/6), one case achieved complete response, four showed disease progression (PD), and one exhibited no response. As expected, ASXL1 mutation was predictive for the outcome of CMML (hazard ratio of 2.97, 95% confidence interval of 1.21-7.06; P = 0.02).

Conclusion
The use of DEC combined with RUX in the treatment of CMML effectively improved the clinical response and quality of life, especially for CMML-1 patients. Ongoing clinical trials will further evaluate the safety and efficacy of this novel therapeutic approach.
Treatment results of childhood extracranial malignant germ cell tumors and the salvage approach for recurrent and refractory cases: a single-center report
Authors: He Kejun , Yuan Xiaojun , Tan Zhen 
Published: June 2023

Abstract

Objective
The aim of this study is to report the treatment result of childhood excranial malignant germ cell tumors and discuss the experience for recurrent and refractory cases treatment from our center.

Methods
We have retrospectively analyzed 58 extracranial malignant germ cell tumor patients treated with surgery and chemotherapy from our center over a 9-year period. Another 14 recurrent and refractory cases referred from other centers were added to the study for salvage approach. We evaluated the treatment results for primary cases and relapsed cases with a median follow-up of 61.5 months. Several factors were analysed to evaluate their power to the outcome of these cases.

Results
The 5-year event-free and overall survival for primary cases were 74.1±5.7% and 86.2±4.5%, respectively. 25 recurrent or refractory cases entered the salvage approach study, and 17 patients were alive till the end of follow-up. We demonstrated superior survival outcome for those with successful local control through pre-operative and post-operative radiotherapy, second-look surgery and multi-drug second-line chemotherapies.

Conclusion
The outcome for childhood extracranial malignant germ cell tumors is generally favorable. For recurrent and refractory cases, multi-modality treatment approaches including radiotherapy, salvage chemotherapy and secondlook surgery are important for better local control.
Prognostic risk model construction and prognostic biomarkers identification in esophageal adenocarcinoma based on immune-related long noncoding RNA*
Authors: Qin Kai , Cheng Yi , Zhang Jing , Yuan Xianglin , Wang Jianhua , Bai Jian 
Published: June 2023

Abstract

Objective
The aim of this study was to construct a prognostic model of esophageal adenocarcinoma (EAC) based on immune-related long noncoding RNAs (immune-related lncRNAs) and identify prognostic biomarkers using the Cancer Genome Atlas (TCGA) database.

Methods
Whole genomic mRNA expression and clinical data of esophageal adenocarcinoma were obtained from the TCGA database. The software Strawberry Perl, R and R packets were used to identify the immune-related genes and lncRNAs of esophageal adenocarcinoma, and for data processing and analysis. The differentially expressed lncRNAs were detected while comparing esophageal adenocarcinoma and normal tissue samples. The key immune-related lncRNAs were screened using lasso regression analysis and univariate cox regression analysis, and used to construct the prognostic model using multivariate cox regression analysis.
To evaluate the accuracy of the risk prognostic model, all esophageal adenocarcinomas were divided into high-risk and low-risk groups according to the median risk score, after which Kaplan-Meier (K-M) survival curves, operating characteristic (ROC) curve and independent prognostic analysis of clinical traits were created. In addition, statistically significant immune-related lncRNAs and potential prognostic biomarkers were identified using the prognostic model and multifactor cox regression analysis for k-m survival analysis.

Results
A total of 1322 differentially expressed immune-related lncRNAs were identified, 28 of which were associated with prognosis via univariate cox regression analysis. In addition, K-M survival analysis showed that the total survival time of the higher risk group was significantly shorter than that of the lower risk group (P = 1.063e-10). The area under the ROC curve of 5-year total survival rate was 0.90. The risk score showed independent prognostic risk for esophageal adenocarcinoma via single factor and multifactorial independent prognostic analyses. In addition, the HR and 95% CI of each key immune-related lncRNA were calculated using multivariate Cox regression. Using k-m survival analysis, we found that 5 out of 12 key significant immune-related lncRNAs had independent prognostic value [AL136115.1 (P = 0.006), AC079684.1 (P = 0.008), AC07916394.1 (P = 0.0386), AC087620.1 (P = 0.041) and MIRLET7BHG (P = 0.044)].

Conclusion
The present study successfully constructed a prognostic model of esophageal adenocarcinoma based on the TCGA database, with moderate predictive accuracy. The model consisted of the expression level of 12 immune-related lncRNAs. Furthermore, the study identified one favorable prognostic biomarker, MIRLET7BHG, and four poor prognostic biomarkers (AL136115.1, AC079684.1, AC016394.1, and AC087620.1).
Elevated pretreatment plasma fibrinogen level is associated with metastasis of non-small cell lung cancer (NSCLC)
Authors: Shi Bowen , Bu Jianlong , Wang Yanbo , Chen Lantao , Xu Shidong 
Published: June 2023

Abstract

Objective
The aim of this study was to investigate the correlation between pretreatment fibrinogen levels and metastasis in non-small cell lung cancer (NSCLC).

Methods
The study included 503 NSCLC patients with a clear pathological diagnosis and 168 patients diagnosed with benign lung diseases by histological examination. Pretreatment plasma fibrinogen values were quantified, and the relationship between plasma fibrinogen level and clinical variables comprising tumor size, metastasis, and clinical stage was examined using Kruskal-Wallis test, Wilcoxon rank sum test, and Chi-square test.

Results
The median plasma fibrinogen values were statistically higher in NSCLC patients with metastasis than patients with benign lung diseases and NSCLC patients without metastasis (Kruskal-Wallis test; P < 0.001). Plasma fibrinogen values were also significantly higher in advanced clinical stages (Wilcoxon rank sum test; P < 0.001). A significant relationship was observed between elevated fibrinogen (> 2.974 g/L) and metastasis, clinical stage, and tumor size (Chi-square test; P < 0.001).

Conclusion
This correlation suggests that elevated pretreatment plasma fibrinogen levels can predict metastasis and advanced tumor stage in NSCLC patients.
Antitumor and vascular effects of apatinib combined with chemotherapy in mice with non-small-cell lung cancer
Authors: Cao Hui , Wang Shili , Liu Yaohui 
Published: June 2023

Abstract

Objective
The aim of this study was to investigate the antitumor and vascular effects of apatinib use combined with chemotherapy on mice with non-small-cell lung cancer (NSCLC).

Methods
First, 60 tumor-bearing nude mice were randomly divided into control, low-dose, and high-dose groups. Four nude mice per group were sacrificed before administration and on days 1, 3, 7, and 10 after administration. HIF-1α expression in tumor tissues was detected. Second, 32 nude mice were randomly divided into control, premetrexed, synchronous, and sequential groups. The weights and tumor volumes of mice were recorded.

Results
(1) HIF-1α expression decreased significantly on days 3 and 7 after low-dose apatinib treatment. There was no significant difference in HIF-1α expression in the high-dose apatinib group (P > 0.05). MMP-2 and MMP-9 expression levels in the low-dose apatinib group were significantly lower than those in the control group (P < 0.05). (2) In the low-dose apatinib group, the microvessel density increased gradually from days 3 to 7 post-treatment, while that in the high-dose apatinib group decreased significantly. (3) The inhibitory effect of sequential therapy using low-dose apatinib and pemetrexed was optimal, while that of synchronous treatment was not better than that of pemetrexed usage alone. Sequential treatment using low-dose apatinib and pemetrexed exerted the best antitumor effect. (4) The expression levels of p-AKT, p-mTOR, p-MEK, and p-ERK in the sequential group were significantly lower than those in the other three groups (P < 0.05).

Conclusion
Apatinib usage involves certain considerations, such as dose requirements and time window for vascular normalization during lung cancer treatment in nude mice, suggesting that dynamic contrast-enhanced magnetic resonance imaging and other tests can be conducted to determine the vascular normalization window in patients with lung cancer and to achieve the optimal anti-vascular effect.
Nonlinear changes in pupillary attentional orienting responses across the lifespan
Authors: Riley Elizabeth , Turker Hamid , Wang Dongliang , Swallow Khena M , Anderson Adam K , De Rosa Eve 
Published: June 2023

AbstractThe cognitive aging process is not necessarily linear. Central task-evoked pupillary responses, representing a brainstem-pupil relationship, may vary across the lifespan. Thus we examined, in 75 adults ranging in age from 19 to 86, whether task-evoked pupillary responses to an attention task may serve in as an index of cognitive aging. This is because the locus coeruleus (LC), located in the brainstem, is not only among the earliest sites of degeneration in pathological aging, but also supports both attentional and pupillary behaviors. We assessed brief, task-evoked phasic attentional orienting to behaviorally relevant and irrelevant auditory tones, stimuli known specifically to recruit the LC in the brainstem and evoke pupillary responses. Due to potential nonlinear changes across the lifespan, we used a novel data-driven analysis on 6 dynamic pupillary behaviors on 10% of the data to reveal cut off points that best characterized the three age bands: young (19–41 years old), middle aged (42–68 years old), and older adults (69 + years old). Follow-up analyses on independent data, the remaining 90%, revealed age-related changes such as monotonic decreases in tonic pupillary diameter and dynamic range, along with curvilinear phasic pupillary responses to the behaviorally relevant target events, increasing in the middle-aged group and then decreasing in the older group. Additionally, the older group showed decreased differentiation of pupillary responses between target and distractor events. This pattern is consistent with potential compensatory LC activity in midlife that is diminished in old age, resulting in decreased adaptive gain. Beyond regulating responses to light, pupillary dynamics reveal a nonlinear capacity for neurally mediated gain across the lifespan, thus providing evidence in support of the LC adaptive gain hypothesis.
Preliminary Study on Low-Pressure Cold Spray Process Parameters: Effect on Mechanical and Photocatalytic Properties of TiO2 Coatings
Authors: Seremak W. , Jasiorski M. , Baszczuk A. , Winnicki M. 
Published: June 2023

AbstractThe TiO2 photocatalytic coatings’ most important properties are durability and photocatalytic activity. Those features form a basis to determine its degree of usefulness. In this study, the self-synthesized amorphous TiO2 powder was used for low-pressure cold spray photocatalytic coatings. Two strategies were adopted to change the surface properties, which can influence the mechanical properties of the coatings: (I) reduction of the scanning step and (II) filling the depressions in the already sprayed coating with the second layer. The coatings surface topography (measured by roughness and waviness) results showed that the first strategy makes coatings thicker, with a more uniform surface. The second strategy leads to obtaining more rough surfaces with no significant change in the thickness. The preliminary study results indicate that the first strategy was superior to the other one, in terms of both mechanical (described by cohesion and adhesion) and photocatalytic (measured by the decomposition of methylene blue under UV) properties of the coatings.
Graphical Abstract
An immune related signature inhibits the occurrence and development of serous ovarian cancer by affecting the abundance of dendritic cells
Authors: Teng Fei , Wei Hong , Dong Xiaoqiu 
Published: June 2023

AbstractSerous ovarian cancer is one of the major causes of cancer related death among women worldwide. The advanced diagnosis worsens the prognosis of patients with serous ovarian cancer. The immune system has an important impact on the progression of ovarian cancer. Herein, we aimed to establish an immune related prognostic signature to assist in the early diagnosis, treatment, and prognostic evaluation of patients with serous ovarian cancer. Multiple public data sets and immune related genes were obtained from various online public databases, and immune related prognostic signatures were developed through differential expression analysis, univariate Cox proportional hazard regression analysis, and the Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression model. The nomogram model, Kaplan–Meier survival curve analysis, receiver operating characteristic (ROC) curve analysis, and decision curve analysis showed that this signature had a good prediction potential. In conclusion, an immune related signature with good prediction efficiency was established through systematic bioinformatics analysis, which may play a tumor inhibition role by affecting the abundance of activated dendritic cells.
Optimization of surfactant-polymer flooding for enhanced oil recovery
Authors: Ahmed M. Elmuzafar , Sultan Abdullah S. , Al-Sofi Abdulkarim , Al-Hashim Hasan S. 
Published: June 2023

AbstractChemical enhanced oil recovery applications continue to face a variety of obstacles, particularly in high saline and high-temperature reservoirs, in addition to high chemical prices. This issue creates difficulty in developing optimal recipes that can withstand these extreme circumstances and so achieve maximal hydrocarbon recovery at the lowest feasible cost. The usefulness of surfactant polymer (SP) in mobilizing oil and increasing sweep efficiency in carbonate rocks is assessed in this article. A thermo-viscosifying polymer and an acrylamido tertiary butyl sulfonate (ATBS)/acrylamide (AM) copolymer were employed. Surfactants of various grades of amphoteric carboxybetain are used. These potential chemicals were chosen after a thorough study of previous research, which included long-term thermal stability, fluid rheology, interfacial tension, adsorption, and microfluidic tests. The contact angles were measured using a captive drop analyzer at high pressure and high temperature. The core-flooding experiments for slug size and injection sequence optimization were carried out using 12-inch long and 1.5-inch diameter limestone cores. For two weeks, the samples were aged. The trials were carried out at 90 °C. The seawater (SW) salinity utilized in the injection was 57,000 ppm. The findings highlighted the importance of surfactant-polymer interactions in wettability and fluid rheology. The best chemical combination was carboxybetaine (0.05 wt%) and ATBS/AM (0.25 wt%) which recovered 31.29% of the residual oil saturation (ROS), or 11.63% of the original oil in place (OIIP). The optimal slug size was 3.5 PV, which recovered 34.21% of the ROS and 17.05% of the OIIP. The optimum injection sequence was the co-injection of surfactant and polymer SW-S1P1-SW, which extracted 31.29% of the ROS and 11.63% of the OIIP. The recoveries were discovered to be related to the slug’s size. The chemical injection sequence was critical to the eventual oil recovery. Among the other sequences, SW-SP-SW had the highest recovery (SW-P-S-SW, SW-S-SW-P-SW, and SW-P-SW-S-SW). This is thought to be owing to the compounds' synergistic impact. We found that there is no systematic optimization process that combines the effect of chemicals, slug size, and sequence in one study, which gave us the motivation to cover the research gap.
Common stationary point of multivalued asymptotically regular mappings
Authors: Khan Abdul Rahim , Oyetunbi Dolapo Muhammed , Izuchukwu Chinedu 
Published: June 2023

AbstractWe establish a relationship between asymptotic regularity and common stationary points of multivalued mappings on a metric space. As a consequence of our results, we obtain a new common fixed point result for two asymptotically regular single-valued mappings. Our work significantly improves and complements comparable results in the literature.
Coxiella burnetii Infection in Livestock, Pets, Wildlife, and Ticks in Latin America and the Caribbean: a Comprehensive Review of the Literature
Authors: Epelboin Loïc , De Souza Ribeiro Mioni Mateus , Couesnon Aurelie , Saout Mona , Guilloton Edith , Omar Salma , De Santi Vincent Pommier , Davoust Bernard , Marié Jean Lou , Lavergne Anne , Donato Damien , Guterres Alexandro , Rabier Sebastien , Destoop Justin , Djossou Felix , Baudrimont Xavier , Roch Antoine , Cicuttin Gabriel Leonardo , Rozental Tatiana , Nacher Mathieu , Millán Javier , De Lemos Elba R. Sampaio , Fernandes Jorlan , Duron Olivier , De Thoisy Benoit , Rousset Elodie 
Published: June 2023

Abstract
Purpose of the Review
Q fever
, a bacterial zoonosis caused by Coxiella burnetii, is reported very heterogeneously in humans in Latin America. The objective of this study was to review the data on Coxiella burnetii Infection in animals in Latin America and the Caribbean.

Recent Findings
A comprehensive literature review was carried out in the 47 countries and territories of Latin America on various search engines and grouped into four groups: livestock, pets, wildlife, and ticks.

Summary
Thus, 113 studies were selected between 1950 and 2022. Among the 47 countries, only 25 (53%) had at least one publication related to C. burnetii infection in animals. The most productive country was Brazil (N = 51), followed by French Guiana (N = 21), and Colombia (N = 16). Studies in livestock from 20 countries have shown widely varying country-to-country rates of seroprevalence, ranging from 0 to 67%. Some studies from seven countries, especially French Guiana and Brazil, found antibodies and sometimes positive PCR in dogs and cats, generally in the context of investigations around human clustered cases. Knowledge remained fragmented about infection in wildlife from only five countries (Chile, Colombia, Brazil, French Guiana, and Uruguay). C. burnetii infection was identified by PCR in Chiroptera (7 species), Rodentia (6 species), Suina (2 species), Xenartha (1 species), Cingulata (1 species), and Perissodactyla (1 species). Studies on Coxiella sp. in ticks have been performed in 11 countries, mostly in Brazil, and mainly found Coxiella-like endosymbionts. Thus, data on C. burnetii infection in animals are sparse and incomplete in Latin America and the Caribbean, and more research is warranted.
Peer-Led Versus Conventional Teacher-Led Methodological Research Education Sessions: An Initiative to Improve Medical Education Research Teaching
Authors: Bantounou Maria Anna , Kumar Niraj 
Published: June 2023

Abstract
Introduction
To enhance doctors’ engagement with research, the National Medical Research Association (NMRA) developed a research teaching series, delivering peer-led (PL) sessions by medical students and conventional teacher-led (CL) sessions by licenced physicians/lecturers. We assessed the effectiveness of the series and compared the PL and CL approaches.

Methods
The teaching sessions were delivered virtually via Zoom weekly either PL or CL. Feedback was provided by participants on completion of every session using a 10-point Likert scale assessing their knowledge pre- and post-training.

Results
A total of 87 participants were included generating 782 feedback forms, 367 (47.1%) for PL and 412 for CL sessions. The median knowledge scores significantly increased following each session (p-value < 0.05) independent of teaching approach. An overall improvement in the median knowledge score from all sessions from 5/10 to 8/10 was reported. There was no significant difference between knowledge gained from the CL or PL teaching.

Conclusion
Didactic PL research training sessions are equally effective as CL sessions.
Temperature Bias Drift Phase-Based Compensation for a MEMS Accelerometer with Stiffness-Tuning Double-Sided Parallel Plate Capacitors
Authors: Li Mingkang , Ma Zhipeng , Zhang Tengfei , Jin Yiming , Ye Ziyi , Zheng Xudong , Jin Zhonghe 
Published: June 2023

AbstractThis paper reports an approach of in-operation temperature bias drift compensation based on phase-based calibration for a stiffness-tunable MEMS accelerometer with double-sided parallel plate (DSPP) capacitors. The temperature drifts of the components of the accelerometer are characterized, and analytical models are built on the basis of the measured drift results. Results reveal that the temperature drift of the acceleration output bias is dominated by the sensitive mechanical stiffness. An out-of-bandwidth AC stimulus signal is introduced to excite the accelerometer, and the interference with the acceleration measurement is minimized. The demodulated phase of the excited response exhibits a monotonic relationship with the effective stiffness of the accelerometer. Through the proposed online compensation approach, the temperature drift of the effective stiffness can be detected by the demodulated phase and compensated in real time by adjusting the stiffness-tuning voltage of DSPP capacitors. The temperature drift coefficient (TDC) of the accelerometer is reduced from 0.54 to 0.29 mg/°C, and the Allan variance bias instability of about 2.8 μg is not adversely affected. Meanwhile, the pull-in resulting from the temperature drift of the effective stiffness can be prevented. TDC can be further reduced to 0.04 mg/°C through an additional offline calibration based on the demodulated carrier phase representing the temperature drift of the readout circuit.