bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to assess economic progress in the era of discontinuity?
Authors: Hązła Marceli , Mińska‐Struzik Ewa 
Published: March 2023

AbstractThe aim of this article is to contribute to the discussion on designing alternative economic development indices by measuring economic progress in the face of the discontinuity of globalisation. To this end, we use different evaluation criteria for the ‘old’ (1960–1990) and the ‘new’ (1990–2019) globalisation. First, the historical context that has shaped the contemporary globalisation processes is outlined, which makes it possible to identify the 1990s and the subsequent change in the structure of the world industrial production and the world GDP as the most important tipping point. Based on the observation that none of the existing indices sufficiently cover all the issues, a new pilot measure of economic progress is proposed, which takes into account two time periods: the old (1960–1990) and the new (1990–2019) globalisation. The analysis of the data sample of 18 countries (G6, I6 and selected LDCs) using this measure makes it possible to assign their economies to four categories, depending on the results they have achieved; the ‘winners’, the ‘losers’, the ‘late‐bloomers’ and the ‘inmates of industry’. Furthermore, possible directions for the future research on the subject are indicated. The data set supporting this study has been made publicly available to help in its continuation.
Investigating the clinical impact of dose‐banding for weekly paclitaxel in patients with breast cancer: A retrospective and monocentric study
Authors: Puisset Florent , Le Louedec Félicien , Dalenc Florence , Verguet Lorène , De Maio Eleonora , Lacaze Jean Louis , Montastruc Marion , Ung Mony , Vinson Camille , Perriat Sophie , Pacher Sandrine , Chatelut Etienne , Koning Mélanie White 
Published: March 2023

AimsDose‐banding (DB) consists in approximating the theoretical dose of anticancer drugs calculated according to the body surface area (Dose‐BSA) of patients. This concept is supported by pharmacokinetic but not by clinical data. The aim of this study was to assess the clinical outcome of DB defined as dose‐fitting up to ±10%.MethodsThis was a retrospective study conducted in patients receiving weekly paclitaxel in neoadjuvant (NAT) and metastatic (M+) settings. Three groups of patients were considered according to type of paclitaxel dosing: Dose‐BSA, DB approximated down (DB‐Low) and DB approximated up (DB‐High). Efficacy was evaluated by the rate of pathological complete response for patients in NAT setting and by the median of progression‐free survival plus overall survival for those in M+ setting. Toxicity and efficacy were compared in the 3 groups.ResultsA total of 224 and 209 patients were assessable in the M+ and NAT settings, respectively. A toxic event was observed for 31.7 and 27.3% in M+ and NAT, respectively. The rate of pathological complete response was 41.6% in NAT. The median progression‐free survival was 5.2 (4.1–5.8) months and overall survival was 16.3 (14.6–18.4) months for patients in M+. Efficacy and toxicity were not different in DB‐Low and DB‐High groups compared to Dose‐BSA group.ConclusionDB with approximated doses up to ±10% does not seem to influence clinical outcome of patients treated with weekly paclitaxel. This is the first study to include clinical observations, which lends support to DB as a safe and effective dosing method.
Subfield‐specific longitudinal changes of hippocampal volumes in patients with early‐stage bipolar disorder
Authors: Atwood Bruce , Yassin Walid , Chan Shi Yu , Hall Mei‐Hua 
Published: March 2023

AbstractBackgroundThe hippocampus is a heterogeneous structure composed of biologically and functionally distinct subfields. Hippocampal aberrations are proposed to play a fundamental role in the etiology of psychotic symptoms. Bipolar disorder (BPD) has substantial overlap in symptomatology and genetic liability with schizophrenia (SZ), and reduced hippocampal volumes, particularly at the chronic illness stages, are documented in both disorders. Studies of hippocampal subfields in the early stage of BPD are limited and cross‐sectional findings to date report no reduction in hippocampal volumes. To our knowledge, there have been no longitudinal studies of BPD evaluating hippocampal volumes in the early phase of illness. We investigated the longitudinal changes in hippocampal regions and subfields in BPD mainly and in early stage of psychosis (ESP) patients more broadly and compared them to those in controls (HC).MethodsBaseline clinical and structural MRI data were acquired from 88 BPD, from a total of 143 ESP patients, and 74 HCs. Of those, 66 participants (23 HC, 43 patients) completed a 12‐month follow‐up visit. The hippocampus regions and subfields were segmented using Freesurfer automated pipeline.ResultsWe found general baseline deficits in hippocampal volumes among BPD and ESP cohorts. Both cohorts displayed significant increases in the anterior hippocampal region and dentate gyrus compared with controls. Additionally, antipsychotic medications were positively correlated with the posterior region at baseline.ConclusionThese findings highlight brain plasticity in BPD and in ESP patients providing evidence that deviations in hippocampal volumes are adaptive responses to atypical signaling rather than progressive degeneration.
How did the disclosure of lobbying targeting Quebec's hospitals become mandatory and with what effect?
Authors: Ouimet Mathieu , Savoie Justin , Montigny Éric 
Published: March 2023

AbstractIn 2015 mandatory disclosure activity for lobbying that targeted health and social service centres in Quebec, a sector which consumes a significant share of the annual spending budget, suddenly became a mandatory disclosure activity for lobbyists operating in the province. This research note traces the trajectory of key events that led to this shift towards greater lobbying transparency in the health care sector. The study also analyzes whether this change was followed by increased lobbying registrations for activities targeting health sector institutions. The article's findings suggest that significant change in lobbying regulation may occur accidentally, against the government's will, rather than as a result of an ethical scandal, cross‐jurisdictional learning, or electoral calculations, as the literature suggests. The article's findings also show that the change was followed by an increase of about 969 registered firm lobbyists (p‐value 0.015) and 254 registered lobbyists from covered NGOs (p‐value 0.00).
Transcriptional and open chromatin analysis of bovine skeletal muscle development by single‐cell sequencing
Authors: Cai Cuicui , Wan Peng , Wang Hui , Cai Xin , Wang Jiabo , Chai Zhixin , Wang Jikun , Wang Haibo , Zhang Ming , Yang Nan , Wu Zhijuan , Zhu Jiangjiang , Yang Xueyao , Li Yulian , Yue Binglin , Dang Ruihua , Zhong Jincheng 
Published: March 2023

AbstractSkeletal muscle is a complex heterogeneous tissue and characterizing its cellular heterogeneity and transcriptional and epigenetic signatures are important for understanding the details of its ontogeny. In our study, we applied scRNA‐seq and scATAC‐seq to investigate the cell types, molecular features, transcriptional and epigenetic regulation, and patterns of developing bovine skeletal muscle from gestational, lactational and adult stages. Detailed molecular analyses were used to dissect cellular heterogeneity, and we deduced the differentiation trajectory of myogenic cells and uncovered their dynamic gene expression profiles. SCENIC analysis was performed to demonstrate key regulons during cell fate decisions. We explored the future expression states of these heterogeneous cells by RNA velocity analysis and found extensive networks of intercellular communication using the toolkit CellChat. Moreover, the transcriptomic and chromatin accessibility modalities were confirmed to be highly concordant, and integrative analysis of chromatin accessibility and gene expression revealed key transcriptional regulators acting during myogenesis. In bovine skeletal muscle, by scRNA‐seq and scATAC‐seq analysis, different cell types such as adipocytes, endothelial cells, fibroblasts, lymphocytes, monocytes, pericyte cells and eight skeletal myogenic subpopulations were identified at the three developmental stages. The pseudotime trajectory exhibited a distinct sequential ordering for these myogenic subpopulations and eight distinct gene clusters were observed according to their expression pattern. Moreover, specifically expressed TFs (such as MSC, MYF5, MYOD1, FOXP3, ESRRA, BACH1, SIX2 and ATF4) associated with muscle development were predicted, and likely future transcriptional states of individual cells and the developmental dynamics of differentiation among neighbouring cells were predicted. CellChat analysis on the scRNA‐seq data set then classified many ligand–receptor pairs among these cell clusters, which were further categorized into significant signalling pathways, including BMP, IGF, WNT, MSTN, ANGPTL, TGFB, TNF, VEGF and FGF. Finally, scRNA‐seq and scATAC‐seq results were successfully integrated to reveal a series of specifically expressed TFs that are likely to be candidates for the promotion of cell fate transition during bovine skeletal muscle development. Overall, our results outline a single‐cell dynamic chromatin/transcriptional landscape for normal bovine skeletal muscle development; these provide an important resource for understanding the structure and function of mammalian skeletal muscle, which will promote research into its biology.
Synergy between health technology assessments and clinical guidelines for multiple sclerosis
Authors: Hogervorst Milou A. , Vreman Rick A. , Zawada Anna , Zielińska Magdalena , Dawoud Dalia M. , de Jong Brigit A. , Mantel‐Teeuwisse Aukje K. , Goettsch Wim G. 
Published: March 2023

AbstractDecision‐making for reimbursement and clinical guidelines (CGs) serves different purposes although the decision‐criteria and required evidence largely overlap. This study aimed to assess similarities and discrepancies between health technology assessment (HTA) reports as compared to CGs for multiple sclerosis (MS) medicines. All HTA reports and corresponding CGs for MS from the UK, France, Germany, the Netherlands, Poland, Sweden, and the European Union were assessed to identify synergies in recommendations for MS medicines (approved 1995–2020). A content analysis of HTA reports and CGs was performed to identify similarities and discrepancies in wording of treatment recommendations across documents. We assessed 132 HTA reports and 9 CGs for 16 MS treatments. Final recommendations for reimbursement and inclusion in CGs were mostly similar (90%), albeit with considerable differences in treatment lines and subindications. Since 2010, HTA reports refer to the use of CGs in 42% (55/132) and to consultations with clinicians in 43% (57/132) of cases. Six of nine CGs referred to HTA reports and two referred to HTA consultations, in one case having a formal relation to the HTA organization. CGs referenced pharmacoeconomic studies (4/9) for costs and cost‐effectiveness. To date, not all new HTA recommendations for MS treatments are included in CGs. Some synergy exists between treatment recommendations in HTA reports and CGs, although discrepancies were seen in timelines and in recommended treatment lines and subindications. More stakeholder dialogue and/or consultation of each other's publications may further improve synergy, facilitate transparency, and enhance patient access.
Psychosocial correlates of drinking transitions: A longitudinal study among adolescents in Sweden
Authors: Sjödin Lars , Karlsson Patrik , Raninen Jonas 
Published: March 2023

AbstractIntroductionNon‐drinkers have been shown in older studies to have poorer mental health and social life compared to their alcohol‐using counterparts. Given the profound decline in adolescent drinking observed in most high‐income countries, this pattern may have changed. This study explores drinking transitions and examines psychosocial factors among adolescents by longitudinal drinking status.MethodsData were based on two waves of a prospective longitudinal nationwide study (n = 4018). The first wave (T1) of data was collected in 2017 (age 15/16) and the second wave (T2) was in 2019 (age 17/18). Respondents were asked about their past year drinking status, general health, psychosomatic problems, psychiatric medication, school enjoyment, emotional symptoms, peer relationship problems, prosocial ability, friendships satisfaction and satisfaction with relation to mother/father. Comparisons by mean values were assessed and multinomial logistic regressions were used to examine associations.ResultsAbstainers and later drinkers differed significantly from early drinkers on 9/10 factors respectively at T1. Fewer psychosomatic problems, less psychiatric medication, higher school enjoyment, more emotional symptoms, higher parental relationship satisfaction, more peer problems and lower friendships satisfaction at T1 were associated with abstaining and/or later drinking. All factors were more strongly associated with abstaining. School enjoyment predicted abstaining but not later drinking.Discussion and ConclusionsLongitudinal drinking status relates to small to moderate systematic psychosocial differences. Adolescents with better mental health, more content relationships with parents and lower friendships satisfaction are more often abstainers. Those generally worse off are more likely early drinkers but they also have better friendships.
Concealing borrowers’ failure history in online P2P lending: A natural experiment
Authors: Bai Jiaru , Gao Qiang 
Published: March 2023

AbstractOnline peer‐to‐peer (P2P) platforms both disclose and conceal borrowers’ information. Minimal research has been conducted on the impact of concealing such information on borrowers’ funding success. We fill this research gap by exploring a natural experiment opportunity at Prosper, an online lending marketplace where the platform enacted a policy to conceal borrowers’ past failure history. We first find that the platform's decision to conceal such information can be rational because when this information was publicly available, borrowers with past failures had lower success rates than borrowers without past failures. We next investigate the effect of hiding this information on lenders' lending decisions. Our empirical results from a series of analyses demonstrate that concealing such information helps some borrowers but also surprisingly leads to an overall lower success rate, which ultimately harms the platform and runs counter to the platform's intention. These effects are strongest for low‐risk borrowers and would attenuate in the long run. We further find that the number of borrowers’ past failures is associated with lower repayment ability.
Metabolomic profiles in serum and urine uncover novel biomarkers in children with nephrotic syndrome
Authors: Hu Lidan , Lin Li , Huang Guoping , Xie Yi , Peng Zhaoyang , Liu Fei , Bai Guannan , Li Wei , Gao Langping , Wang Yan , Li Qiuyu , Fu Haidong , Wang Jingjing , Sun Qingnan , Mao Jianhua 
Published: March 2023

AbstractBackgroundNephrotic syndrome is common in children and adults worldwide, and steroid‐sensitive nephrotic syndrome (SSNS) accounts for 80%. Aberrant metabolism involvement in early SSNS is sparsely studied, and its pathogenesis remains unclear. Therefore, the goal of this study was to investigate the changes in initiated SSNS patients‐related metabolites through serum and urine metabolomics and discover the novel potential metabolites and metabolic pathways.MethodsSerum samples (27 SSNS and 56 controls) and urine samples (17 SSNS and 24 controls) were collected. Meanwhile, the non‐targeted analyses were performed by ultra‐high‐performance liquid chromatography‐quadrupole time of flight‐mass spectrometry (UHPLC‐QTOF‐MS) to determine the changes in SSNS. We applied the causal inference model, the DoWhy model, to assess the causal effects of several selected metabolites. An ultraperformance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) was used to validate hits (D‐mannitol, dulcitol, D‐sorbitol, XMP, NADPH, NAD, bilirubin, and α‐KG‐like) in 41 SSNS and 43 controls. In addition, the metabolic pathways were explored.ResultsCompared to urine, the metabolism analysis of serum samples was more clearly discriminated at SSNS. 194 differential serum metabolites and five metabolic pathways were obtained in the SSNS group. Eight differential metabolites were identified by establishing the diagnostic model for SSNS, and four variables had a positive causal effect. After validation by targeted MS, except XMP, others have similar trends like the untargeted metabolic analysis.ConclusionWith untargeted metabolomics analysis and further targeted quantitative analysis, we found seven metabolites may be new biomarkers for risk prediction and early diagnosis for SSNS.
Differential utility of various frailty diagnostic tools in non‐geriatric hospital departments of several countries: A longitudinal study
Authors: Checa‐Lopez Marta , Rodriguez‐Laso Angel , Carnicero Jose Antonio , Solano‐Jaurrieta Juan Jose , Saavedra Obermans Olga , Sinclair Alan , Landi Francesco , Scuteri Angelo , Álvarez‐Bustos Alejandro , Sepúlveda‐Loyola Walter , Rodriguez‐Manas Leocadio 
Published: March 2023

AbstractBackgroundThere is limited knowledge on the performance of different frailty scales in clinical settings. We sought to evaluate in non‐geriatric hospital departments the feasibility, agreement and predictive ability for adverse events after 1 year follow‐up of several frailty assessment tools.MethodsLongitudinal study with 667 older adults recruited from five hospitals in three different countries (Spain, Italy and United Kingdom). Participants were older than 75 years attending the emergency room, cardiology and surgery departments. Frailty scales used were Frailty Phenotype (FP), FRAIL scale, Tilburg and Groningen Frailty Indicators, and Clinical Frailty Scale (CFS). Analyses included the prevalence of frailty, degree of agreement between tools, feasibility and prognostic value for hospital readmission, worsening of disability and mortality, by tool and setting.ResultsEmergency Room and cardiology were the settings with the highest frailty prevalence, varying by tool between 40.4% and 67.2%; elective surgery was the one with the lowest prevalence (between 13.2% and 38.2%). The tools showed a fair to moderate agreement. FP showed the lowest feasibility, especially in urgent surgery (35.6%). FRAIL, CFS and FP predicted mortality and readmissions in several settings, but disability worsening only in cardiology.ConclusionsFrailty is a highly frequent condition in older people attending non‐geriatric hospital departments. We recommend that based upon their current feasibility and predictive ability, the FRAIL scale, CFS and FP should be preferentially used in these settings. The low concordance among the tools and differences in prevalence reported and predictive ability suggest the existence of different subtypes of frailty.
Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions
Authors: Diederich Sophie , Hemmeter Ulrich , Paulmann Maren , Mockenhaupt Maja 
Published: March 2023

AbstractObjectiveThis study was undertaken to determine the impact of dosage in new users of lamotrigine (LTG) and the concomitant intake of valproic acid (VPA) on epidermal necrolysis (EN).MethodsA total of 102 EN cases with exposure to LTG were identified (1992–2018) in the German Registry of Severe Skin Reactions. All cases are validated by an independent expert committee. Six cases were excluded due to lack of exposure in the relevant time frame. Causality assessment was performed with ALDEN (Algorithm for Assessment of Drug Causality in EN) on definite/probable cases (≥12 years; n = 84). Evaluation of dosing regimen was restricted to cases with complete LTG dosing history (n = 74).ResultsDemography showed a mean age of 42.4 years, female predominance (69%), and low mortality (7.3%). Epilepsy was the indication for use in 87.5%. LTG was the very probable cause in 71.4% and probable cause in 28.6%. On average, one additional antiseizure medication was taken, most frequently VPA (43/84). Combined LTG/VPA treatment showed no statistically significant difference in morbidity or mortality. Mean time latency from initiation of LTG to reaction onset was 24.2 days, varying between 21 days with high initial dose and 29.2 days with low initial dose. Low initial LTG dose (n = 9) revealed higher mortality (22.2%) and higher severity (5/9) than high initial dose (n = 35, mortality = 14.3%, 14/35 higher severity). No patient died when the starting dose was as recommended. The highest mortality (25%) was found in patients with no dose increase (n = 8), which correlated with higher age. Despite the recommended or low initial dose, 52.7% of patients developed EN, in contrast to 39.2% with a slow, recommended, or no dose escalation.SignificanceNeither the initial dose, dose escalation, nor the combination with VPA seems to influence the general occurrence of EN. However, EN patients with the recommended starting dose and the recommended dose escalation had the best outcome in terms of clinical severity and mortality.
The hub genes and their potential regulatory mechanisms in chronic spontaneous urticaria revealed by integrated transcriptional expression analysis
Authors: Liu Runqiu , Lv Dong , Cao Lihua , Liu Yu , Wen Xiaoting , Jiang Yannan , Xu Jiandan , Qin Jie , Qin Pingping 
Published: March 2023

AbstractChronic spontaneous urticaria (CSU) is a recurrent disease characterized by wheals and or angioedema, and its pathogenesis is still unclear. The microarray datasets of skin tissue from CSU patients and healthy controls were integrated and analysed in Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified using the NetworkAnalyst tool. Then, the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Subsequently, a protein–protein interaction (PPI) network of DEGs was constructed by STRING and the related hub genes were identified through the MOCDE tool. The potential miRNAs targeting hub genes were predicted based on the intersection of three online databases, namely TargetScanHuman, TargetBase and miRNet. Differentially expressed lncRNAs (DElncRNAs) was performed using the GEO2R tool. The potential miRNAs targeting DElncRNAs were predicted through miRNet. Finally, the shared miRNAs targeting both hub genes and DElncRNAs were used to construct an mRNA/miRNA/lncRNA regulatory network. A total of 296 DEGs were obtained, which were mainly enriched in inflammatory and immune responses. Further, 14 hub genes were identified by the PPI network of DEGs. Clinical correlation analysis showed that the mRNA expressions of S100A7, S100A8, S100A9, S100A12, IL6 and SOCS3 in CSU were positively correlated with the 7‐day urticaria activity score (UAS7), and their potential diagnostic value was supported by the receiver operating characteristic curve (ROC) analysis. Five up‐regulated lncRNAs in the cytoplasm were obtained by DElncRNAs analysis. The ROC analysis showed that PVT1, SNHG3 and ZBTB20 − AS1 was of potential diagnostic value for CSU. Eight shared miRNAs targeting both hub genes and DElncRNAs were identified and used to construct a competing endogenous RNA (ceRNA) network. It was found that the IL‐6/miR − 149 − 5p/ZBTB20 − AS1 axis might play an important role in the activation of mast cells in CSU. IL‐6 and its related regulatory molecules may be used as potential diagnostic markers and therapeutic targets for CSU.