bluuebunny/crossref_metadata_2025_split huggingface dataset:
CRISPR screen identifies CEBPB as contributor to dyskeratosis congenita fibroblast senescence via augmented inflammatory gene response
Authors: Westin Erik R , Khodadadi-Jamayran Alireza , Pham Linh K , Tung Moon Ley , Goldman Frederick D 
Published: September 2023

Abstract
Aging is the consequence of intra- and extracellular events that promote cellular senescence. Dyskeratosis congenita (DC) is an example of a premature aging disorder caused by underlying telomere/telomerase-related mutations. Cells from these patients offer an opportunity to study telomere-related aging and senescence. Our previous work has found that telomere shortening stimulates DNA damage responses (DDRs) and increases reactive oxygen species (ROS), thereby promoting entry into senescence. This work also found that telomere elongation via TERT expression, the catalytic component of the telomere-elongating enzyme telomerase, or p53 shRNA could decrease ROS by disrupting this telomere–DDR–ROS pathway. To further characterize this pathway, we performed a CRISPR/Cas9 knockout screen to identify genes that extend life span in DC cells. Of the cellular clones isolated due to increased life span, 34% had a guide RNA (gRNA) targeting CEBPB, while gRNAs targeting WSB1, MED28, and p73 were observed multiple times. CEBPB is a transcription factor associated with activation of proinflammatory response genes suggesting that inflammation may be present in DC cells. The inflammatory response was investigated using RNA sequencing to compare DC and control cells. Expression of inflammatory genes was found to be significantly elevated (P &lt; 0.0001) in addition to a key subset of these inflammation-related genes [IL1B, IL6, IL8, IL12A, CXCL1 (GROa), CXCL2 (GROb), and CXCL5]. which are regulated by CEBPB. Exogenous TERT expression led to downregulation of RNA/protein CEBPB expression and the inflammatory response genes suggesting a telomere length-dependent mechanism to regulate CEBPB. Furthermore, unlike exogenous TERT and p53 shRNA, CEBPB shRNA did not significantly decrease ROS suggesting that CEBPB's contribution in DC cells’ senescence is ROS independent. Our findings demonstrate a key role for CEBPB in engaging senescence by mobilizing an inflammatory response within DC cells.
Contrasting Evolutionary Patterns Between Sexual and Asexual Lineages in a Genomic Region Linked to Reproductive Mode Variation in the pea aphid
Authors: Rimbault Maud , Legeai Fabrice , Peccoud Jean , Mieuzet Lucie , Call Elsa , Nouhaud Pierre , Defendini Hélène , Mahéo Frédérique , Marande William , Théron Nicolas , Tagu Denis , Le Trionnaire Gaël , Simon Jean-Christophe , Jaquiéry Julie 
Published: September 2023

Abstract
Although asexual lineages evolved from sexual lineages in many different taxa, the genetics of sex loss remains poorly understood. We addressed this issue in the pea aphid Acyrthosiphon pisum, whose natural populations encompass lineages performing cyclical parthenogenesis (CP) and producing one sexual generation per year, as well as obligate parthenogenetic (OP) lineages that can no longer produce sexual females but can still produce males. An SNP-based, whole-genome scan of CP and OP populations sequenced in pools (103 individuals from 6 populations) revealed that an X-linked region is associated with the variation in reproductive mode. This 840-kb region is highly divergent between CP and OP populations (FST = 34.9%), with &gt;2,000 SNPs or short Indels showing a high degree of association with the phenotypic trait. In OP populations specifically, this region also shows reduced diversity and Tajima’s D, consistent with the OP phenotype being a derived trait in aphids. Interestingly, the low genetic differentiation between CP and OP populations at the rest of the genome (FST = 2.5%) suggests gene flow between them. Males from OP lineages thus likely transmit their op allele to new genomic backgrounds. These genetic exchanges, combined with the selection of the OP and CP reproductive modes under different climates, probably contribute to the long-term persistence of the cp and op alleles.
Criminal Responsibility by Omission for Failures to Stop Autonomous Weapon Systems
Authors: Bo Marta 
Published: September 2023

Abstract
This article deals with establishing the criminal responsibility, through the model of commission by omission, of autonomous weapon systems (AWS) users in situations where failures to suspend AWS-driven attacks have caused a war crime. The author tackles the question of whether an omission to stop such an AWS may amount to the actus reus of war crimes of unlawful attacks and does so by establishing how the doctrine of commission by omission can be applied on the basis of the grave breaches regime in the First Additional Protocol to the Geneva Conventions and the Rome Statute of the International Criminal Court. In deconstructing the status of commission by omission under both these legal frameworks, this article analyses whether the substantive conditions of commission by omission, namely, the legal duty to act and the capacity to act, are met. The author suggests that ‘human control’, manifested in the ability to supervise, intervene and stop an AWS-driven attack, should be considered a necessary pre-condition for the imputation of criminal responsibility in at least some expected scenarios of AWS use. In the absence of such human control, there would be no accountability for unlawful attacks, including indiscriminate attacks, caused by AWS, which would lead to impunity for such crimes. On the one hand, the attribution of responsibility by omission has, therefore, crucial implications for closing the ‘responsibility gap’ within this context. On the other hand, based on the analysis of ‘control’ as the key principle for criminal responsibility by omission, the author argues that an additional treaty obligation should be adopted to ensure human control over AWS and preserve accountability for potential unlawful attacks.
Do Work Permits Work? The Impacts of Formal Labor Market Integration of Syrian Refugees in Jordan
Authors: Peitz Laura , Baliki Ghassan , Ferguson Neil T N , Brück Tilman 
Published: September 2023

AbstractThe integration of refugees into host countries’ formal labor markets is increasingly recommended as a durable solution to forced migration. Yet, this policy response is a contentious political topic with little empirical evidence, especially in low- and middle-income host countries available to support policy. This article examines the impacts of integrating Syrian refugees into Jordan’s formal labor market. We use robust greedy one-to-one propensity score matching on comprehensive high-quality data from almost 75,000 Syrian refugee households collected between 2017 and 2019 to generate novel evidence on the socio-economic benefits of refugee labor market integration. Our findings show that the ability to access formal jobs, reflected by holding a work permit, is significantly associated with increased refugee income, strengthens food security, and reduces protection needs and child labor. These findings contribute to a better and knowledge-based understanding of a prominent policy response for forced migrants.
‘The Decision to Return to Syria Is Not in My Hands’: Syria’s Repatriation Regime as Illiberal Statebuilding
Authors: Abboud Samer 
Published: September 2023

Abstract
Many Syrian refugees are being forcibly repatriated under the guise of the war’s end, while other refugees are returning to Syria voluntarily. Drawing on an interview study with displaced Syrians, and an analysis of conflict-era policy and legal changes, I show how the Syrian government’s repatriation regime has been constructed outside of international norms and practices. An absentee must apply to return through a settlement process in which the state determines who is a ‘loyal returnee’ and thus permitted to return. Returnees must construct a genealogy of loyalty that attributes responsibility for their displacement towards several of the Syrian government’s enemies. Wartime Housing, Land, and Property (HLP) laws have created a surrogate legal category for the displaced as absentee subjects who are targeted for punishment through HLP seizures. As Syria’s repatriation regime is delinked from restitution, returnees are forced to navigate HLP laws to regain ownership of assets and property.
Pilonidal cyst of the scalp
Authors: Gao Yingjun , Hui Yun , Liu Haibo , An Binyi , Liu Fang 
Published: September 2023

Abstract
A 19-year-old male patient presented with a slow-growing mass on his scalp over a 10-year history. After resecting the mass, he was diagnosed with pilonidal cyst based on the clinical and histological findings. An unusual pilonidal disease is observed on the scalp in this report.
Metastatic osseous disease of unknown primary origin: a case report and review of literature
Authors: Dougherty Alleyna , Moore Lauren , Atkins Lori 
Published: September 2023

Abstract
Cancer of unknown primary (CUP) is a heterogeneous group of metastatic tumors in the absence of a clinically identifiable site. We describe the case of a 66-year-old female with an extensive history of non-specific imaging concerning for malignancy who did not undergo further workup and in whom a diagnosis of CUP was made. The patient initially presented to her specialist with concern of right leg pain. Imaging at that time was concerning for a progressive malignant process. Given this, the patient was referred urgently for surgery. Final surgical pathology and breast prognostic panel were consistent with metastatic breast carcinoma at that time. Follow-up imaging performed 1-week postoperatively did not show suspicious findings in either breast, further supporting a diagnosis of CUP. To this end, we highlight the importance of follow-up imaging but recognize the challenges facing healthcare professionals in navigating the ethical principles of nonmalificience and beneficence in diagnostic workup.
Liver transplantation for polycystic liver disease: a case report
Authors: Niibek Maris , Uksov Andrei 
Published: September 2023

Abstract
A 57-year-old man complained about abdominal distension and pain, constant feeling of early satiety. He was diagnosed with polycystic kidneys at the age of 24 and liver cysts discovered at the age of 38. The CT scan revealed 33 x 21 x 27 cm polycystic liver with cysts up to 7 cm in diameter. In 2009–2019 the patient was repeatedly punctured for liver cysts. Considering the continued enlargement of the liver and the worsening of complaints, the patient was put on the waiting list for a liver transplant in the spring of 2019. The patient went through liver transplantation on 11th of July 2022, the liver measures were 53 x 37 x 39 x 16 cm and weight 14,75 kg. The postoperative course was uneventful. Liver transplantation can be very effective treatment method that significantly improves the quality of life in PLD patients.
Bilateral enlarged concha bullosa: a case report and literature review
Authors: Alsalamah Shmokh , Jarman Yazeed , Alsanea Mohammd , Asiri Mohammed , Alhedaithy Riyadh 
Published: September 2023

Abstract
Concha Bullosa (CB) is a common sinonasal anatomical variant, which commonly extends into the middle turbinate. Generally, patients presenting with CB are asymptomatic and often incidentally diagnosed with a non-contrast computed tomography scan of the paranasal sinuses. In cases of extensive pneumatization, large CB may cause significant signs and symptoms—commonly, headaches, nasal obstruction, and hyposmia. With only a few reported cases of large CB in the literature; we herein, report a rare case of an unusually massive bilateral CB that resulted in complete obstruction of the left nasal cavity and partial obstruction of the right nasal cavity, in addition to a review of relevant literature.
Unusual cause of chronic abdominal pain in a 17-year-old female: a case report of an epithelial adrenal cyst
Authors: Zakkor Mohammed D , Alafandi Bana Z , Danial Aghyad K , Lbabidi Nour , Almohandes Reda A , Agha Sarab , Al Hussein Hachem , Ayoub Kusay 
Published: September 2023

Abstract
Adrenal cysts are rare lesions that make up 4% of all adrenal masses. They are often found incidentally during imaging or surgery and can vary in symptoms depending on their size and location; with cysts &lt; 10 cm often being asymptomatic. These cysts are more common in adults in their 30s or 60s and can be divided into four histological subtypes, with epithelial cysts being less common. We present a case of a 17-year-old female who experienced recurrent right flank pain for a year. Ultrasonography revealed a cystic mass on the right kidney, and computerized tomography showed a well-defined suprarenal cyst measuring ~8 cm misdiagnosed as mesenteric cyst. However, during laparoscopy, an adrenal cyst was discovered, which was excised along with the right adrenal gland. Histopathology confirmed the diagnosis of an epithelial adrenal cyst. This case highlights the occurrence of adrenal cysts in younger individuals and the uncertainty of preoperative diagnosis.
A case of life-threatening, early postoperative refeeding syndrome in an obese young female undergoing laparoscopic sleeve gastrectomy
Authors: Chiu Tricia R , Waller Jake H , Meslin Sylvain M M , Talbot Michael L , Jorgensen John J , Fisher Oliver M 
Published: September 2023

Abstract
Early complications after a laparoscopic sleeve gastrectomy (LSG) include bleeding, leaks, strictures and bowel obstructions. Patients post-LSG experience rapid but intended weight loss and may be on a restricted diet before and following surgery. Thus, many of these patients are in a malnourished state, placing them at a risk of developing potentially life-threatening refeeding syndrome (RFS). We describe the case of an 18-year-old female who developed RFS 2 weeks after LSG. We examine potential causes, review literature and discuss RFS pathophysiology as well as the guidelines that could help prevent RFS in bariatric surgery. Currently, not much is known about the risk of RFS in bariatric surgery and to our knowledge, this is the first report of RFS occurring in the early postoperative phase after LSG. A globally accepted definition of RFS should be established for guidelines to encompass wider patient groups.
Anesthesia for awake craniotomy: a case report
Authors: Alanzi Ahmed Khaled , Hakmi Samah , Adeel Shahid , Ghazzal Samar Yaser 
Published: September 2023

Abstract
Awake craniotomy (AC) is a neurosurgical technique that enables the precise localization of functional neural networks through intraoperative brain mapping and real-time monitoring. This operative method has been popularized in recent years due to decreased postoperative morbidities. We present a case of 31-year-old female who was presented with episodes of generalized tonic colonic seizures. She had a history of recurring seizures. Upon further investigations, she was diagnosed with brain space-occupying lesions initially suspected as low-grade glioma. Considering the lesion site, the patient was deemed a suitable candidate for an AC. To achieve conscious sedation, the patient received infusions of remifentanil and propofol at varying rates. During the procedure, the patient was under sedation and was regularly tested for response to predetermined commands. The tumor was successfully excised by using a combination of local anesthesia on the scalp and by the administration of propofol and boluses through a systemic infusion.
Challenges in diagnosis and treatment: a case report on a mixed malignant Müllerian tumor
Authors: Saenz Daniela , Fernández Jorge D , Cóbar Juan P 
Published: September 2023

Abstract
Mixed malignant Müllerian tumors (MMMTs) are rare and aggressive neoplasms made up of both carcinomatous and sarcomatous components that primarily appear in the female reproductive tract. The cellular origin of this malignancy has eluded advancements in molecular and immunohistochemical techniques contributing to the limited diagnostic and therapeutic strategies. This case report presents a 41-year-old female with a history of abnormal uterine bleeding and dysmenorrhea who was later diagnosed with an MMMT. This case highlights the importance of considering MMMTs in patients with a long-standing history of abnormal uterine bleeding because the prompt recognition and diagnosis of this condition may lead to an improved overall survival for these patients.
The role of non-genetic parents in a surrogate-born child’s identity: an argument for removal of the genetic link requirement
Authors: Park-Morton Lottie 
Published: September 2023

Abstract
For the court to grant a parental order recognising intended parents as legal parents of a surrogate-born child, the gametes of at least one of the intended parents must have been used to create the embryo, under section 54(1)(b) and section 54A(1)(b) Human Fertilisation and Embryology Act 2008. In the Law Commission and Scottish Law Commission’s consultation paper, there was a provisional proposal to remove the genetic link requirement in cases of medical necessity. However, this proposal was not included in the Law Commissions’ Final Report, instead recommending the retention of the requirement for a genetic link in almost all circumstances. This article contends that the Law Commissions’ recommendation should be reconsidered in light of the child’s right to identity. By reviewing how identity has been used by the courts when determining whether to grant a parental order, as well as a developing interpretation of Article 8 of the United Nations Convention on the Rights of the Child and European Convention on Human Rights, it can be asserted that the identity of surrogate-born children necessitates recognition of the relationship between the child and intended parent(s), irrespective of a genetic link. On this basis, it is argued that there should be the possibility for intended parents to establish legal parenthood following surrogacy without the requirement for a genetic link.
Boolean-Valued Sets as Arbitrary Objects
Authors: Horsten Leon 
Published: September 2023

Abstract
This article explores the connection between Boolean-valued class models of set theory and the theory of arbitrary objects in roughly Kit Fine’s sense of the word. In particular, it explores the hypothesis that the set-theoretic universe as a whole can be seen as an arbitrary entity. According to this view, the set-theoretic universe can be in many different states. These states are structurally like Boolean-valued models, and they contain sets conceived of as variable or arbitrary objects.
Zinc and aging: a narrative review of the effects on hematopoiesis and its link with diseases
Authors: Lima Fabiana Da Silva , Gonçalves Carlos Eduardo Da Silva , Fock Ricardo Ambrósio 
Published: September 2023

Abstract
There has been a global increase in the older population in recent decades and, as age advances, complex metabolic and epigenetic changes occur in the organism, and these may trigger some health complications commonly found among this population. Additionally, several changes occur in older people that can reduce the dietary intake or the process of nutrient absorption. In this way, tissues with high nutrient requirements are more affected. Hematopoiesis is the process of formation, development, and maturation of blood cells and is a process with a high turnover. This high demand makes the integrity of the hematopoietic process susceptible to various factors that impair physiological function, such as aging and micronutrient bioavailability. Among these micronutrients, Zinc is considered an important micronutrient, playing diverse roles across various tissues and cell types. Some of the alterations in hematopoiesis that appear as a consequence of aging and due to insufficient micronutrient intake are well described in the literature; however, not much is known about how zinc deficiency contributes towards the development of diseases seen in aging. Considering the importance of zinc to act on several biological processes, this narrative review discusses several studies related to the physiological requirements, deficiency, or excess of zinc, including studies in experimental models and humans, and aimed to shed light on the relationship between zinc and the regulation of hematopoietic tissue, exploring possible links between this mineral with common disorders that appear during aging.
Personality and Survey Satisficing
Authors: Sturgis Patrick , Brunton-Smith Ian 
Published: September 2023

Abstract
In this paper, we consider the role of personality as a component of motivation in promoting or inhibiting the tendency to exhibit the satisficing response styles of midpoint, straightlining, and Don’t Know responding. We assess whether respondents who are low on the Conscientiousness and Agreeableness dimensions of the Big Five Personality Inventory are more likely to exhibit these satisficing response styles. We find large effects of these personality dimensions on the propensity to satisfice in both face-to-face and self-administration modes and in probability and nonprobability samples. People who score high on Conscientiousness and Agreeableness were less likely to be in the top decile of straightlining and midpoint distributions. The findings for Don’t Know responding were weaker and only significant for Conscientiousness in the nonprobability sample. We also find large effects across all satisficing indicators for a direct measure of cognitive ability, where existing studies have mostly relied on proxy measures of ability such as educational attainment. Sensitivity analysis suggests the personality effects are likely to be causal in nature.
The Effects of Elite Attacks on Copartisan Media: Evidence from Trump and Fox News
Authors: Archer Allison M N 
Published: September 2023

Abstract
Individuals seeking news content face a variety of options in the current media landscape, yet scholarly research provides little evidence regarding the conditions under which they might become more or less open to different partisan news outlets. Drawing on the case of Donald Trump’s critiques of Fox News, I argue that elite rhetoric plays an important role in this process for members of both parties. I first conduct an original content analysis of Trump’s tweets from 2017 to 2020 and find that he increasingly attacked Fox News on this platform. Notably, Trump’s increasingly critical rhetoric about Fox correlates significantly with decreases in both Fox’s daytime and prime-time ratings. Two survey experiments shed light on how individuals respond to this intraparty conflict, and I find that Trump’s rhetoric affects both Republicans and Democrats. Republicans view Fox as less conservative and more critical of Trump when exposed to his critiques of the outlet. However, Republicans do not change their viewing habits until Trump promotes an alternative to Fox like OANN. Democrats respond to Trump’s rhetoric by updating their perceptions of Fox’s coverage and ideology as well as increasing their willingness to watch the channel, both in isolation and relative to an alternative like OANN. The results suggest that elite rhetoric is instrumental in shaping views of and demand for partisan outlets among members of both parties and can elevate more ideologically extreme sources among followers. Thus, elite rhetoric serves as a meaningful cue for individuals navigating an increasingly fragmented partisan media landscape.