bluuebunny/crossref_metadata_2025_split huggingface dataset:
Education as identity
Authors: Jones Ben 
Published: March 2023

AbstractIn eastern Uganda “being educated” is an identity that people work on throughout their lives. They develop an educated identity through participating on committees, educating their children, and subscribing to a recognizable set of behaviors. Education is a “scaffold” that can be built up or knocked down, one that is related to, but broader than, experiences of going to school or being young. Moreover, “being educated” has ongoing political advantages: those who are seen as more educated tend to prevail in disputes and fare better with various authorities, and they are more likely to benefit from government and NGO schemes. Examples from different social situations highlight the need for an ethnographically open, relationally aware, and politically attuned approach to what people are doing when claiming an educated identity.
The election
Authors: Rethmann Petra 
Published: March 2023

Summary“The election” tells the story of the 2000 regional election in Chukotka, Russia's northeasternmost part. That year, Lyosha, a Chukchi activist, invited me to assist Indigenous movements with grant writing for Western‐based civil society organizations. When I arrived in Chukotka, the election was in full swing and turned out to be more bizarre as—as Lyosha put it—could be believed. The gifting of the oligarch, the lies told by the governor, the dreaming of Lyosha, and the interrogation of the anthropologist are all things that happened, and I wanted to tell their story. But I also wanted to describe what did not happen: the democracy that was not desired or embraced. The result, I hope, is a story that shows not only what it felt like to be part of this election but also what Russia was at that time, why it has possibly become what it has become, and how and why elections leave ghosts. The narrative form has been inspired by the Russian literary tradition of the skaz, an absurdist form of narrative where things rarely are what they pretend to be.
Outcomes of immediate facial nerve reanimation with nerve transfer for facial nerve neoplasm‐induced paralysis: a retrospective review
Authors: Shein Gregory , Lee Jennifer W. Y. , Coulson Susan , Low Tsu‐Hui (Hubert) 
Published: March 2023

AbstractBackgroundThe purpose of this study was to evaluate the outcomes of our polyneural, zone‐based reanimation approach for patients with neoplasm‐induced facial paralysis.MethodsA retrospective review of consecutive patients who underwent facial reanimation surgery using multiple donor nerve transfers was undertaken. In each case, the selection of donor nerves was based on the availability of donor nerve and the viability of the motor endplate on the affected side. Sources of the neural inputs utilized included the remnant facial nerve stump, masseteric nerve, partial hypoglossal nerve, and branches of the contralateral facial nerve. Clinical outcomes were scored by expert raters. Ratings were undertaken using the modified House‐Brackmann, eFACE and MEEI FACEgram scoring systems.ResultsBetween 2017 and 2020, 12 patients were included in the study (mean age 60 years; range 26–81 years). Eight patients (67%) achieved a grade III outcome on the modified House‐Brackmann grading scale. Mean eFACE static and dynamic scores were 76 and 57 respectively, reflecting a high degree of symmetry at rest and moderate restoration of dynamic movement. Mean time to movement was 5.4 months (SD 1.9). Objective FACE‐gram measurements confirmed restoration of midface movement with an average improvement in smile excursion and mouth angle excursion of 3.19 mm (SD 3.18) and 4.81° (SD 2.90) respectively.ConclusionFacial reanimation using multiple nerve transfers is effective in achieving improvements in facial function and symmetry.
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high‐grade serous ovarian cancer
Authors: Deng Feng , Laasik Maren , Salminen Liina , Lapatto Lauri , Huhtinen Kaisa , Li Yilin , Hautaniemi Sampsa , Hynninen Johanna , Niemi Mikko , Lehtonen Rainer 
Published: March 2023

AbstractAdverse effects are the major limiting factors in combinatorial chemotherapies. To identify genetic associations in ovarian cancer chemotherapy‐induced toxicities and therapy outcomes, we examined a cohort of 101 patients receiving carboplatin‐paclitaxel treatment with advanced high‐grade serous ovarian cancers. Based on literature and database searches, we selected 19 candidate polymorphisms, designed a multiplex single nucleotide polymorphism‐genotyping assay and applied Cox regression analysis, case–control association statistics and the log‐rank Mantel−Cox test. In the Cox regression analysis, the SLCO1B3 rs1052536 AA‐genotype was associated with a reduced risk of any severe toxicity (hazard ratio = 0.35, p = 0.023). In chi‐square allelic test, the LIG3 rs1052536 T‐allele was associated with an increased risk of neuropathy (odds ratio [OR] = 2.79, p = 0.031) and GSTP1 rs1695 G allele with a poorer response in the first‐line chemotherapy (OR = 2.65, p = 0.026). In Kaplan–Meier survival analysis, ABCB1 rs2032582 TT‐genotype was associated with shorter overall survival (uncorrected p = 0.025) and OPRM1 rs544093 GG and GT genotypes with shorter platinum‐free interval (uncorrected p = 0.027) and progression‐free survival (uncorrected p = 0.012). Results suggest that SLCO1B3 and LIG3 variants are associated with the risk of adverse effects in patients receiving carboplatin‐paclitaxel treatment, the GSTP1 variant may affect the treatment response and ABCB1 and OPRM1 variants may influence the prognosis.
A matter of time: The influence of underperformance duration on corporate misconduct
Authors: Zhao Amy Tong , Xiao Shufeng 
Published: March 2023

AbstractResearch Question/IssueThis study examines firms' reactions to the duration of underperformance. We posit that firms are more likely to engage in misconduct to solve the problem of underperformance as the length of time a firm has been underperforming prolongs. Further, we investigate how divergent external governance actors shape underperforming firms' motivation for misconduct and consequently affect their responses to underperformance duration.Research Findings/InsightsUsing bivariate probit estimations for panel data of 2662 Chinese publicly listed firms during 2007–2018, we uncover that underperformance duration is positively associated with the likelihood of a corporate misconduct commission. In addition, the positive relationship between the duration of firm underperformance and corporate misconduct is mitigated by the level of state ownership but reinforced by the number of analysts covering the firm.Theoretical/Academic ImplicationsThis study extends the behavioral theory of the firm by incorporating the construct of underperformance duration from a time perspective, which is a proactive signal of firms' illicit decisions. We show that the duration of underperformance is positively associated with the likelihood of corporate misconduct, which is moderated by the firms' external governance actors who have different time pressures to solve financial problems.Practitioner/Policy ImplicationsThis study offers insights for regulators interested in the prevention of ex‐ant misconduct. Identifying underperformance duration as a critical predictor of illegal activities helps to improve regulators' vigilance. Moreover, a holistic executive evaluation system that shows more tolerance for short‐term underperformance is needed.
High‐throughput mechano‐cytometry as a method to detect apoptosis, necroptosis, and ferroptosis
Authors: Van der Meeren Louis , Verduijn Joost , Krysko Dmitri V. , Skirtach André G. 
Published: March 2023

AbstractIn recent years, the importance of the investigation of regulated cell death (RCD) has significantly increased and different methods are proposed for the detection of RCD including biochemical as well as fluorescence assays. Researchers have shown that early stages of cell death could be detected by using AFM. Although AFM offers a high single‐cell resolution and sensitivity, the throughput (<100 cells/h) limits a broad range of biomedical applications of this technique. Here, a microfluidics‐based mechanobiology technique, named shear flow deformability cytometry (sDC), is used to investigate and distinguish dying cells from viable cells purely based on their mechanical properties. Three different RCD modalities (i.e., apoptosis, necroptosis, and ferroptosis) are induced in L929sAhFas cells and analysed using sDC. Using machine learning on the extracted parameters, it was possible to predict the dead or viable state with 92% validation accuracy. A significant decrease in elasticity can be noticed for each of these RCD modalities by analysing the deformation of the dying cells. Analysis of morphological characteristics such as cell size and membrane irregularities also indicated significant differences in the RCD induced cells versus control cells. These results highlight the importance of mechanical properties during RCD and the significance of label‐free techniques, such as sDC, which can be used to detect regulated cell death and can be further linked with sorting of live and dead cells.
Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling
Authors: Liu Stephanie N. , Agarwal Priya , Heinig Katja , Datye Asim , Sturm‐Pellanda Carolina , Crugnola Andrea , Arca Marc , Miles Dale 
Published: March 2023

AbstractAlectinib, approved as 150 mg capsules for the treatment of adults with advanced ALK‐positive non‐small cell lung cancer, is being assessed in children with ALK‐positive solid and central nervous system tumors. An ad hoc pediatric‐friendly suspension of alectinib, prepared from capsule contents, is under investigation as an alternative formulation for children who cannot swallow capsules. This randomized, crossover, relative bioavailability, and food effect study evaluated alectinib administered as an oral suspension versus capsule formulation following conventional venipuncture and capillary microsampling. A total of 28 healthy adult subjects received a 600 mg single dose of alectinib in two groups: fasted (n = 14) and mixed fed (n = 14; seven receiving high‐fat meal and seven receiving low‐fat meal). Combined alectinib + M4 (active metabolite) exposure was higher for suspension versus capsule, with geometric mean ratio (GMR) of 2.6 for area under the concentration–time curve extrapolated to infinity (AUC0‐∞) and 3.0 for maximum observed concentration (Cmax) under fasted conditions, and 1.7 for both parameters for mixed fed. The suspension showed increased alectinib + M4 AUC0‐∞ following a high‐fat meal versus fasted conditions (GMR 1.7 [90% confidence interval 1.4–2.2]). Alectinib AUC0‐∞ and Cmax measured in venous and capillary samples were generally similar for the suspension and capsule. Single oral doses of 600 mg alectinib suspension and capsule were well tolerated, with no safety concerns. Based on these findings, the oral suspension of alectinib appears suitable for use in pediatric studies after appropriate dose adjustment relative to the capsule.
Order effect of multi‐touchpoints on Generation Z consumers
Authors: Fu Xiaorong , Ren Xiangming 
Published: March 2023

AbstractAbundant user‐generated content has increasingly driven consumers to form or modify their purchasing decisions based on interactions with other consumers, although the extant research overlooks the customer‐to‐customer (C2C) interaction touchpoints. Based on the customer journey characteristics of cross‐channel and multi‐frequency interactions, this study explores the impact of interaction valence and interaction channel sequence on Generation Z consumers' purchase attitudes from the perspective of attitude modification process. Using a scenario‐based experimental design in a restaurant setting, we sample 616 Generation Z students. Findings suggest that C2C interactions that have the same valence at each touchpoint strengthen Generation Z consumers' initial purchase attitude, whereas inconsistent valences modify purchase attitudes. Our results reveal that a negative‐to‐positive ordering is more conducive to the formation of a positive purchase attitude than a positive‐to‐negative ordering. Moreover, the cross‐channel sequence of a customer journey moderates the inconsistent valence order such that the positive‐to‐negative order improves purchase attitude more than the negative‐to‐positive order. This study explains theoretically the difference of ambivalent experiences on Generation Z consumer attitudes. We provide practical suggestions for multi‐channel restaurant enterprises to successfully employ customer journey touchpoint management.
Prescription psychostimulants as a harm reduction and treatment intervention for methamphetamine use disorder and the implications for nursing clinical practice: A scoping review of the literature
Authors: Leidl Don , Takhar Pearl , Li Hua 
Published: March 2023

AbstractThe global rise in methamphetamine use and its negative effects warrants the need for research exploring harm reduction and treatment interventions for individuals with methamphetamine use disorder. Agonist medications have been utilized for years for the treatment of heroin and opioid addiction, but have yet to be incorporated into mainstream Canadian practice for methamphetamine dependence. This review aims to provide an overview of the current trends of prescription psychostimulant usage for individuals with methamphetamine use disorder from a Canadian perspective, identifies the barriers to accessing prescription psychostimulants for methamphetamine use disorder and highlights the nursing clinical practice implications in caring for individuals with the disorder. Discourse on the sustained abstinence and harm reduction debate is presented from the perspective of methamphetamine abuse is provided along with the neuropsychiatric complications of chronic methamphetamine use. The impacts of specific prescription psychostimulants on cognition are discussed as is the use of neuroimaging techniques to assess neuronal damage in methamphetamine users. Sign of toxicity, overdose and the contraindications for use of these prescription psychostimulants is also presented. The implications to nursing clinical practice in caring for this population is provided, touching on the clinical presentation of methamphetamine use, completing thorough assessment and screening and patient education. The findings of this review indicate the need for further research in this area exploring the benefits of prescription psychostimulants as a harm reduction and treatment intervention for the global problem of methamphetamine dependence.
Uncovering the hidden biodiversity of streams at the upper distribution limit of fish
Authors: Penaluna Brooke E. , Cronn Rich , Hauck Laura L. , Weitemier Kevin A. , Garcia Tiffany S. 
Published: March 2023

AbstractAimBiodiversity changes can occur gradually or as distinct jumps as species distributions end and others begin. However, comprehensive assessments of freshwater biodiversity and how assemblages change along a continuum have been hindered by the connectivity and networked nature of streams and their large numbers of rare and cryptic species found there. We hypothesize that the boundary where fish distributions end marks an ecological shift in freshwater assemblages and could unify stream concepts.LocationTrask River watershed, Oregon, USA, temperate North America.TaxonFishes, amphibians, crayfishes, bivalves, mammals, pathogens.MethodsWe targeted freshwater species across taxa using multigene eDNA metabarcoding of 48 different DNA barcodes to identify assemblages to understand species patterns distributed along a longitudinal gradient in watersheds around the upper fish distribution boundary. Detections from multiple genetic sources improve the detection probability for rare species.ResultsWe detected a shift in the assemblage from lower reaches towards headwaters where fish distributions end, leading to fewer species across taxa at reduced eDNA signal. We uncovered a hidden biodiversity in watersheds by detecting a sparsely distributed amphibian pathogen Batrachochytrium dendrobatidis, the elusive mammal Mountain Beaver, fish species that went undetected using traditional approaches, and newly discovered cryptic lineages of sculpins. Salmonids were detected further upstream with eDNA than expected.Main conclusionsOur findings unify stream concepts owing to the marked species shift at the upper extent of fish elevating the importance of this boundary. The detection of salmonids further upstream suggests a distribution extension. The sculpin detections reveal a cryptic species complex with ramifications for fish conservation, potential pockets of endemism and possible identification of new species. We show extensive diversity in watersheds, some of which was previously hidden, transforming our understanding of species presence and distributions affecting our ability to track, protect and manage them across watersheds.
The basic helix‐loop‐helix transcription factor gene, OsbHLH38, plays a key role in controlling rice salt tolerance
Authors: Du Fengping , Wang Yinxiao , Wang Juan , Li Yingbo , Zhang Yue , Zhao Xiuqin , Xu Jianlong , Li Zhikang , Zhao Tianyong , Wang Wensheng , Fu Binying 
Published: March 2023

ABSTRACTThe plant hormone abscisic acid (ABA) is crucial for plant seed germination and abiotic stress tolerance. However, the association between ABA sensitivity and plant abiotic stress tolerance remains largely unknown. In this study, 436 rice accessions were assessed for their sensitivity to ABA during seed germination. The considerable diversity in ABA sensitivity among rice germplasm accessions was primarily reflected by the differentiation between the Xian (indica) and Geng (japonica) subspecies and between the upland‐Geng and lowland‐Geng ecotypes. The upland‐Geng accessions were most sensitive to ABA. Genome‐wide association analyses identified four major quantitative trait loci containing 21 candidate genes associated with ABA sensitivity of which a basic helix‐loop‐helix transcription factor gene, OsbHLH38, was the most important for ABA sensitivity. Comprehensive functional analyses using knockout and overexpression transgenic lines revealed that OsbHLH38 expression was responsive to multiple abiotic stresses. Overexpression of OsbHLH38 increased seedling salt tolerance, while knockout of OsbHLH38 increased sensitivity to salt stress. A salt‐responsive transcription factor, OsDREB2A, interacted with OsbHLH38 and was directly regulated by OsbHLH38. Moreover, OsbHLH38 affected rice abiotic stress tolerance by mediating the expression of a large set of transporter genes of phytohormones, transcription factor genes, and many downstream genes with diverse functions, including photosynthesis, redox homeostasis, and abiotic stress responsiveness. These results demonstrated that OsbHLH38 is a key regulator in plant abiotic stress tolerance.
Evaluation of effectiveness of tranexamic acid as mesotherapy in improvement of periorbital wrinkling in a trial study
Authors: Bazargan Afsaneh Sadeghzadeh , Shemshadi Mahsa , Ziaeifar Elham , Taheri Amirmasoud , Roohaninasab Masoumeh , Goodarzi Azadeh , Mirhashemi Mahta 
Published: March 2023

AbstractBackgroundTranexamic acid is used to treat pigmented disorder in dermatology for a long time however there are limited data for effectiveness of tranexamic acid for rejuvenation and improvement of wrinkle. Here we want to find the effectiveness of tranexamic acid as mesotherapy in improvement of periorbital wrinkle in a clinical trial study.MethodsPatients with melasma who were treated with 4 session of tranexamic acid mesotherapy at intervals on 1 week were evaluated with Visioface device before starting and 1 month after last course of treatment. The outcomes including volume, area, area percent, and depth were measured by Visioface device.ResultsMean of periorbital wrinkles volume before and after procedure were 89 271 and 74 639 pixel3 (px3), respectively. Very significant difference with p‐value of <0.001 was detected at volume of patient wrinkles before and after treatment. Moreover, the mean of area (and area percent) of their periorbital wrinkles before and after therapeutic method were 8481 Px3 (1.131%) and 7184 Px3 (0.646%), respectively, with significant differences (both have p‐value of <0.001).Mean of periorbital wrinkles depth at before and after treatment were 9.8 and 9.6, respectively, without remarkable difference (p‐value was 0.257).ConclusionTranexamic acid mesotherapy significantly leads to reduced volume and area of wrinkles. Injection of tranexamic acid as mesotherapy seems to be effective in improvement of periorbital wrinkling.
The impact of refinement on the sensory properties of lanolin
Authors: Danielle Dale , McCabe Morgan , Bourdillon Katie 
Published: March 2023

AbstractTopical lanolin is used to protect the nipples of breastfeeding women. Lanolin differs in color, flavor, and smell, depending on level of refinement. Five lanolin and three non‐lanolin nipple care products, along with two lanolin raw materials, underwent quantitative descriptive analysis by a trained, sensory panel (n = 8). Samples were assessed on appearance, aroma, flavor, mouthfeel, rub‐in and after‐feel characteristics. A two factor ANOVA and Tukey Kramer Honest Significant Difference (HSD) multiple comparison tests were used to identify differences between samples (5%, p = .05). None of the samples had an aroma. A highly purified anhydrous lanolin was rated the palest (score: 2) on an in‐house color chart (scale: 1–66). No difference was noted for flavor and mouthfeel characteristics, moisturization or smoothness of skin. Differences were noted for neat (sample before application) and rub‐in attributes, slipperiness, and skin residue. The sensory profile of lanolin differs depending on refinement processes and differs to non‐lanolin alternatives.Practical applicationsNipple creams should be pleasant to use, neutral in smell and flavor and non‐slippery in texture to prevent interference with breastfeeding. The sensory data presented here indicates that all the lanolin products included in this study met these criteria, however, the ultra‐refined, highly purified lanolin was lightest in color, significantly less sticky, the least greasy and the most spreadable compared to other topical lanolin nipple care products evaluated. This data also suggests that the sensory attributes of non‐lanolin nipple creams differ to lanolin which may influence indications for product use.
Genome characterization of three potyviruses affecting maize in Argentina
Authors: Trucco Verónica , Cabrera Mederos Dariel , Castellanos Collazo Onias , Vaghi Medina Carlos Gastón , Lenardon Sergio , Giolitti Fabian 
Published: March 2023

AbstractArgentina is globally recognized as both producer and exporter of maize, the most important cereal crop in the country. Several potyviruses affect the production of various crops, including maize. In this work, the complete nucleotide sequences of the RNA genome of three potyviruses, johnsongrass mosaic virus (JGMV), maize dwarf mosaic virus (MDMV) and sugarcane mosaic virus (SCMV), isolated from maize were obtained by next‐generation sequencing (Illumina technology). The JGMV, MDMV and SCMV viral genomes were 9780, 9807 and 9729 nucleotides long, respectively. The polyprotein organization of each of potyvirus genome was determined; their sequences showed high values compared with polyprotein sequences of the other isolates reported worldwide (> 76.1% at the nucleotide sequence and > 85% at the amino acid sequence). The results of this work are the first data in Argentina of complete genome sequences of potyviruses obtained from maize and the first obtained for JGMV and MDMV.