bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial Complex I Deficiency: Unraveling the Relevance of NDUFAF1 in Pediatric Hypertrophic Cardiomyopathy
Authors: Kalantari Silvia , Veraldi Daniele , Politano Davide , Apicella Antonia , Castagnoli Riccardo , Foiadelli Thomas , D'Abrusco Fulvio , Giorgio Elisa , Berardinelli Angela , Codazzi Alessia Claudia , Marseglia Gianluigi , Valente Enza Maria , Sirchia Fabio 
Published: January 2025

ABSTRACTHypertrophic cardiomyopathy (HCM) is rare in childhood, but it is associated with significant morbidity and mortality. Genetic causes of HCM are mostly related to sarcomeric genes abnormalities; however, syndromic, metabolic, and mitochondrial disorders play an important role in its etiopathogenesis in pediatric patients. We here describe a new case of apparently isolated HCM due to mitochondrial assembly factor gene NDUFAF1 biallelic variants (c.631C > T and an intragenic deletion encompassing exon 3, NM_016013.4). Alterations of this nuclear gene have been associated to Mitochondrial complex I deficiency, nuclear type 11 (OMIM *618234). We here report the fourth case of a child affected by complex I deficiency due to alterations in NDUFAF1 gene. His clinical features appear simpler when compared to the other cases described in the medical literature, increasing our knowledge regarding the highly heterogeneous clinical presentation associated with this disorder.
Adaptive event‐triggered fault‐tolerant consensus tracking control for switched multi‐agent systems
Authors: Yan Yan , He Xiqin , Wu Libing , Yu Qingkun 
Published: January 2025

AbstractThis paper is devoted to the event‐triggered fault‐tolerant bounded consensus tracking control for switched multi‐agent systems (MASs) with full‐state constraints and actuator faults. By using backstepping technology and fuzzy logic systems (FLSs), an event‐triggered fault‐tolerant control (FTC) scheme is constructed for switched MASs for the first time, which compensates the impact of actuator faults on the system and significantly reduces the updating frequency of controllers. The asynchronous switching error compensation functions are introduced into the designed controller and triggering mechanism, which solves the asynchronous switching problem prompted by the interaction of triggering and switching together effectively. In the meantime, the system states are restricted within the given sets under the barrier Lyapunov functions (BLFs). All the closed‐loop signals are bounded and the bounded consensus tracking control is realized with average dwell time (ADT). Finally, an example of chemical reactors is established for demonstrating the effectiveness of the developed scheme.
Distributed consensus for complex heterogeneous multi‐agent systems under input saturation
Authors: Ma Yuwan , Yang Qingsheng , Zhan Xisheng , Wu Jie , Yan Huaicheng 
Published: January 2025

AbstractThis paper focuses on the consensus problem for heterogeneous multi‐agent systems (HMASs) consisting of second‐order linear agents and nonlinear Euler–Lagrange (EL) agents. Firstly, the HMASs consensus control protocols are designed in the cases of leaderless and leader‐following, respectively. Among them, the research of these two parts is based on the undirected communication topology. Then, through the mathematical knowledge such as graph theory and Lasalle's invariance principle, the sufficient conditions of consensus are given, and the stability of the controller is further proved. At last, the validity of the above theory is proved by simulation results.
What Drives Carbon‐Reducing Investments? A Vignette Experiment on Managers' Decision‐Making From a Multilevel Perspective
Authors: Hahn Rüdiger , Pioch Thomas , Reimsbach Daniel , Schiemann Frank 
Published: January 2025

ABSTRACTOur study aims to shed light on the factors that drive managers' sustainability‐related decision‐making. We take a multilevel perspective, analyzing individual‐, organizational‐, and institutional‐level factors, which allows us to present a coherent account of a complex environment of influential factors. Based on an explorative vignette experiment with professional managers in a setting related to carbon‐reducing investments, we find that certain individual‐level factors, such as managers' biospheric orientation or a strong belief in business ethics, are associated with higher carbon‐reducing investments. However, these individual‐level factors do not alter the overall influence of organizational‐ and institutional‐level factors. The financial impact of carbon‐reducing investments—at the organizational level—as well as the number of carbon‐conscious investors and the regulatory disclosure regime in which a firm operates—at the institutional level—significantly drive managers' investment decisions. We find only a few instances in which specific factor combinations are decision‐relevant. These findings have important implications for research and policymaking with regard to improving corporate sustainability in general and particularly reducing corporate carbon emissions.
ESG Implementations, Green Process Innovation, and Social Performance in Vietnamese Manufacturing Firms: Proactive Environmental Strategy and Green Absorptive Capacity as Moderators
Authors: Van Hien Vo , Abu Afifa Malik , Van Bui Duong 
Published: January 2025

ABSTRACTThis study evaluates the direct and indirect effects of the environmental, social, and governance (ESG) implementations on green process innovation (GPCI) and social performance (SCP) in Vietnamese manufacturing firms, respectively. Exploring the moderating role of proactive environmental strategy (PES) and green absorptive capacity (GAC) on the impact of ESG implementations on GPCI are the next objectives. These investigations are supported by the legitimacy theory and dynamic capability theory. Through the survey method, data collected from 205 managers' responses were analyzed by partial least squares structural equation modeling. The results show important contributions. First, ESG implementations have a positive role in GPCI. Second, GPCI is the driving force behind SCP. Third, ESG implementations have an indirect influence on SCP through GPCI. Fourth, the impact of ESG implementations on GPCI is positively moderated by GAC and PES. Further analysis shows that three‐way interaction (ESG implementations × PES × GAC) enhances GPCI. Therefore, the above results fully support legitimacy theory and dynamic capability theory, and thus they provide highly theoretical contributions and managerial implications.
From subsidies to stressors: Positively skewed ecological gradients alter biological responses to nutrients in streams
Authors: DeVilbiss Stephen E. , Taylor Jason M. , Hicks Matthew B. 
Published: January 2025

AbstractSubsidy–stress gradients offer a useful framework for understanding ecological responses to perturbation and may help inform ecological metrics in highly modified systems. Historic, region‐wide shifts from bottomland hardwood forest to row crop agriculture can cause positively skewed impact gradients in alluvial plain ecoregions, resulting in tolerant organisms that typically exhibit a subsidy response (increased abundance in response to environmental stressors) shifting to a stress response (declining abundance at higher concentrations). As a result, observed biological tolerance in modified ecosystems may differ from less modified regions, creating significant challenges for detecting biological responses to restoration efforts. Using the agriculturally dominated Mississippi Alluvial Plain (MAP) ecoregion in Mississippi, USA, as a case study, we tested the hypothesis that macroinvertebrate taxa that typically display a subsidy response to nutrient enrichment in less modified ecoregions (i.e., nutrient‐tolerance) shift to a stress response to increasing nutrients in highly modified watersheds with elevated baseline nutrient conditions (i.e., nutrient intolerance). The abundance and diversity of MAP‐specific intolerant taxa identified with threshold indicator taxa analysis were either unresponsive or exhibited a subsidy response to increasing nutrients in less modified ecoregions in Mississippi with less land alteration and lower nutrient concentrations, but declined at higher concentrations, providing evidence for a stress response to elevated nutrients in the MAP. Additionally, MAP‐specific tolerant and intolerant taxa richness responded to increased nutrients predictably and consistently across space and time within the MAP. However, in MAP streams, elevated specific conductance was predicted to dampen the response of tolerant and intolerant taxa richness to increasing nutrient concentrations, highlighting the importance of considering multistressor interactions when interpreting biological data. Lastly, we demonstrate the efficacy of this approach with sediment bacterial communities characterized with amplicon sequencing, which lack sufficient life history characteristics necessary for the development of multimetric indices. Both macroinvertebrate and bacterial communities responded similarly to increasing nutrient concentrations, suggesting DNA‐based approaches may provide an efficient biological assessment tool for monitoring water quality improvements in highly modified watersheds.
Palladium Nanoparticles Degrade Advanced Glycation End Products via Valosin‐Containing Protein Mediated Autophagy to Attenuate High‐Glucose/High‐Fat‐Induced Intervertebral Disc Degeneration
Authors: Yang Xiao , Cao Xiankun , Wang Xin , Guo Jiadong , Yang Yangzi , Lu Liqiang , Zhang Pu , Yang Huan , Rong Kewei , Zhou Tangjun , Hao Yongqiang , Zhao Jie , Fu Jingke , Zhang Kai 
Published: January 2025

ABSTRACTIntervertebral disc degeneration (IVDD) is a chronic musculoskeletal disorder causing lower back pain, imposing a considerable burden on global health. Hyperglycemia resulting from diabetes mellitus induces advanced glycation end products (AGEs) accumulation in nucleus pulposus cells, leading to IVDD. Mitigating AGEs accumulation is a novel promising strategy for IVDD management. In our study, palladium nanoparticles (Pd NPs) preferentially colocalized within the endoplasmic reticulum and efficiently degraded AGEs via valosin‐containing protein (VCP)‐mediated autophagy pathways. Pd NPs promoted the ATPase activity of VCPs, upregulated microtubule‐associated proteins 1A/1B light chain 3 (LC3) expression, and increased AGEs‐degrading autophagosome production. They ameliorated mitochondrial function, relieved endoplasmic reticulum stress, and counteracted the detrimental oxidative stress microenvironment in a high‐glucose/high‐fat‐induced nucleus pulposus cell degeneration model. Consequently, Pd NPs effectively rescued nucleus pulposus cell degeneration in vitro, restored disc height and partially recovered the degenerated phenotype of IVDD in vivo. We provide novel insights regarding IVDD management by targeting AGEs degradation, showing potential for clinical practice.
Risk of Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Single Centre, 10‐Year Review
Authors: Won Kelsey V. , Cuddy Karl K. , Chugh Deepika , Magalhaes Marco 
Published: January 2025

ABSTRACTBackgroundOral lichen planus (OLP) and oral lichenoid lesions (OLL) are common chronic inflammatory diseases associated with malignant transformation. Risk factors associated with malignant transformation of OLP and OLL are not well defined.MethodsA retrospective chart review assessed risk factors for progression of OLP and OLL to oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC) at a tertiary care centre in Toronto, Canada.ResultsFive‐hundred‐fifty‐five patients identified with biopsy proven OLP or OLL met the inclusion criteria. In total, 3.2% (n = 18) progressed to OED (1.8%, n = 10) or OSCC (1.4%, n = 8). Risk factors associated with transformation included the plaque‐like subtype (OR = 40.33, p < 0.001) and lesions located on the tongue (OR = 6.81, p = 0.008).ConclusionsClinical examination to identify lesion subtype and location provides useful indicators for risk of progression in patients with OLL and OLP.
A 10 Year Long‐Lived Cellular and Humoral MERS‐CoV Immunity Cross‐Recognizing the Wild‐Type and Variants of SARS‐CoV‐2: A Potential One‐Way MERS‐CoV Cross‐Protection Toward a Pan‐Coronavirus Vaccine
Authors: Alosaimi Bandar , Awadalla Maaweya , Alturaiki Wael , Chen Zhao , Zhang Zhaoyong , Zhu Airu , Rebh Fatimah , Alshukairi Abeer N. , Zhao Jincun , Alkadi Haitham S. 
Published: January 2025

ABSTRACTMERS is a respiratory disease caused by MERS‐CoV. Multiple outbreaks have been reported, and the virus co‐circulates with SARS‐CoV‐2. The long‐term (> 6 years) cellular and humoral immune responses to MERS‐CoV and their potential cross‐reactivity to SARS‐CoV‐2 and its variants are unknown. We comprehensively investigated long‐lasting MERS‐CoV‐specific cellular and humoral immunity, and its cross‐reactivity against SARS‐CoV‐2 and its variants, in individuals recovered from MERS‐CoV infection 1–10 years prior. Two cohorts of MERS‐CoV survivors (31 unvaccinated, 38 COVID‐19 vaccinated) were assessed for MERS‐CoV IgG, memory CD4+/CD8+ T cells, and neutralizing antibodies against MERS‐CoV and SARS‐CoV‐2 variants. MERS‐CoV IgG levels and T cell responses were higher in the 1–5 vs 6–10 year postinfection groups. Vaccinated MERS‐CoV survivors had significantly elevated MERS‐CoV IgG and neutralization compared to unvaccinated. Both groups demonstrated cross‐reactive neutralization of SARS‐CoV‐2 variants. MERS‐CoV survivors vaccinated against SARS‐CoV‐2 had higher anti‐MERS IgG, cellular immunity, and neutralization than unvaccinated survivors. MERS‐CoV immune responses can persist for a decade. COVID‐19 vaccination boosted humoral and cellular immunity in MERS‐CoV survivors, suggesting the benefits of vaccination for this population. These findings have implications for pan‐coronavirus vaccine development.
Multi‐Decadal Variations of Severe Cyclonic Storm Frequency Over the Bay of Bengal and Associated Mechanisms
Authors: Hrudya P. H. , Konda Gopinadh , Chowdary Jasti S. , Gnanaseelan C. , Parekh Anant 
Published: January 2025

ABSTRACTThe present study explores the multi‐decadal variability of Severe Cyclonic Storm (SCS) frequency over the Bay of Bengal (BoB) during post‐monsoon season for the period 1950–2022. The SCS frequency displays noticeable decadal/multi‐decadal variability during the study period, and shows a strong relationship with mid‐tropospheric relative humidity (RH) and sea surface temperature (SST) over BoB. Influence of the large‐scale climate modes, such as Atlantic Multi‐decadal Oscillation (AMO) in modulating the BoB SCS frequency on multi‐decadal time scale is highlighted. It is found that AMO exhibits a significant out‐of‐phase relationship with SCS decadal frequency over the BoB. Detailed analysis suggests that large‐scale circulation changes associated with the negative phase of AMO (strong SCS decade) induced low‐level convergence extending from western Indian Ocean to southern BoB favour increased SCS frequency. A negative AMO (strong SCS period) induced zonally oriented upper‐level convergence and divergence centres, corroborated by the Walker circulation, helped to modulate the low‐level circulation over BoB. High RH and warm SSTs associated with the negative AMO further supported the increased SCS frequency over BoB. In the case of weak SCS decade, positive AMO induced low‐level divergence over southern BoB through atmospheric teleconnections provides unfavourable conditions for SCS formation. In addition to this, changes in the tropospheric temperature over the mid‐latitudes caused by mid‐latitude Rossby waves also contributed to the differences in SCS frequency on the multi‐decadal time scale. This study highlights the role of AMO in modulating the multi‐decadal SCS frequency over the BoB. The results presented here are useful for improving the decadal prediction of cyclone frequency over the BoB.
pH and ROS Dual‐Responsive Core‐Cross‐Linked Micelles Based on Boronic Ester Linkage for Efficient PTX Delivery
Authors: Yu Sunqi , Chen Siyuan , Tong Tianrui , Yan Yunfeng , Shuai Qi 
Published: January 2025

ABSTRACTMicelle‐based drug delivery systems (DDS) have emerged as a promising solution to address challenges associated with the in vivo delivery of hydrophobic anticancer chemotherapeutics. However, micelles still encounter issues such as drug pre‐leakage and poor stability in physiological conditions. To overcome these limitations, we developed a core‐cross‐linking strategy utilizing amphiphilic copolymers, mPEG‐b‐P(AVL‐co‐LA) (mPPAL), functionalized with phenylboronic acid (PBA), and catechol by CuAAc “click” chemistry, respectively. These copolymers self‐assembled into core‐cross‐linked micelles (CLMs), featuring boronic ester bonds, which were characterized through a series of evaluations. The CLMs exhibited a rational particle size, uniform morphology, low critical micelle concentration (CMC), high PTX loading capacity, and excellent stability. Two promising micelles, CLM1 and CLM3, were identified, and their responsiveness to acidic pH and elevated levels of ROS was confirmed to enable controlled PTX release. The results of MTT assay and hemolytic analysis demonstrated high biocompatibility and potential in vivo application of these selected CLMs. The anticancer efficacy of the selected PTX‐CLMs was further validated through MTT assay and 3D tumor spheroid studies. Fluorescence microscopy and flow cytometry demonstrated rapid intracellular uptake of the CLMs. In vivo biodistribution studies demonstrated successful accumulation in the targeted tumor tissue. These findings suggest that the boronic ester‐based CLMs developed in this study are a promising nanocarrier for effective PTX delivery.
Defects Calculation and Accelerated Interfacial Charge Transfer in a Photoactive MOF‐Based Heterojunction
Authors: Lin Yi‐Ming , Cheng Wen‐Wen , Zhang Li‐Chang , Chen Xi‐Fan , Chen Ruiqi , Wang Shouguo , Yang Qingqing , Wang Junzhong , Xiao Juan‐Ding 
Published: January 2025

AbstractPhotocatalytic hydrogen production is currently considered a clean and sustainable route to meet the energy and environmental issues. Among, heterojunction photocatalysts have been developed to improve their photocatalytic efficiency. Defect engineering of heterojunction photocatalysts is attractive due to it can perform as electron trap and change the band structure to optimize the interfacial separation rate of photogenerated electron–hole pairs. Here, the MOF‐based heterojunction photocatalysts with theoretically high reduction and oxidation abilities are successfully synthesized, denoted ZrO2/Pt/Zr‐MOF‐X, with tuned linker defectivity through an in situ electrochemical route. The defectivity are rationally calculated from the TG and 1H NMR results. A positive correlation is found between the defectivity and photocatalytic activity, and ZrO2/Pt/Zr‐MOF‐6 with the optimized defectivity of ca. 35% exhibits the highest hydrogen production rate of up to 2923 µmol g−1 h−1, illustrating the importance of structural defects in heterojunction photocatalysts. Ultrafast transient absorption spectroscopy and electron spin resonance results unveil the highest carrier concentration and charge separation efficiency in the defected heterostructure of ZrO2/Pt/Zr‐MOF‐6 through a direct Z‐scheme contact, leading to its efficient photocatalysis through the high redox power.
Low‐Impedance Hybrid Carbon Structures on SiOX: A Sequential Gas‐Phase Coating Approach
Authors: Zhang Xiaoguang , Zhao Mingcai , Costa Carlos M. , Zhang Juan , Scheiba Frieder , Lanceros‐Méndez Senentxu , Wang Wei , Zhang Qi 
Published: January 2025

AbstractCarbon coating on SiOX surface is crucial for enhancing initial Coulombic efficiency (ICE) and cycling performance in batteries, while also buffering volume expansion. Despite its market prevalence, the effects of the carbon layer's quality and structure on the electrochemical properties of SiOX remain underexplored. This study compares carbon layers produced via gas‐phase and solid‐phase coating methods, introducing an innovative technique that sequentially uses two gases to develop a low‐impedance hybrid carbon structure. In this approach, C3H8 is first deposited to create a short‐range, vertically ordered carbon architecture, followed by C2H2 to establish a long‐range, layered structure, effectively filling the gaps. This results in a dense hybrid carbon layer characterized by minimal defects, high crystallinity, and excellent electronic conductivity. The dominant vertical configuration enhances Li‐ion migration. The SiO@C3H8@C2H2 prepared through this method yields a specific surface area of 1.14 m2 g⁻¹ and a high reversible capacity of 1574.9 mAh g⁻¹, alongside an ICE of 83.7%. It showcases remarkable cycling stability, retaining 86.6% capacity after 1000 cycles at room temperature, and performs effectively under varied temperatures and discharging conditions. This low‐impedance carbon structure provides a significant reference for other anodes that also require a carbon layer.
BIPVslim: Entwicklung kompakter PV‐integrierter Fassadenelemente am Fallbeispiel des CAE Energy Efficiency Centers
Authors: Böke Jens , Suwannapruk Natchai , Vongsingha Puttakhun , Stephan Andreas , Denz Paul‐Rouven 
Published: January 2025

AbstractDie Integration von Photovoltaik (PV) in Gebäude erschließt ein großes Flächenpotenzial für die solare Energiegewinnung und trägt damit maßgeblich zur Energiewende in Deutschland bei. Neben den Dachflächen kommt den Fassaden eine besondere Bedeutung zu. Allerdings führt die Überhitzung in Konstruktionen nach aktuellem Stand der Technik zu hohen Konstruktionstiefen aufgrund notwendiger Hinterlüftung. In der hier beschriebenen Studie wurde eine schlanke Lösung für BIPV‐Warmfassaden entwickelt und beispielhaft am CAE Energy Efficiency Center in Würzburg als Demonstrationsfassade umgesetzt. Das System nutzt Phasenwechselmaterialien (PCM) zur latenten Kühlung und Vakuumisolationspaneele (VIP) zur Wärmedämmung. Der integrale Ansatz ermöglichte eine signifikante Reduktion der Systemdicke bei gleichzeitig hoher Dämmleistung. Angesichts der erfolgreich umgesetzten Demo‐Fassade mit durchgeführtem Monitoring kommt die Untersuchung im Ergebnis zu einer positiven Einschätzung der strukturellen, thermischen und energetischen Eigenschaften der Entwicklung.
Introduction to the Concepts: The Past, Present, and Future of AI
Authors: Aaltonen Päivi , Kurvinen Emil 
Published: January 2025

Abstract
This chapter introduces this book’s background, context, and perspectives. The current literature on the topic is vast, multidisciplinary, and hosting increasingly complex concepts, thus our purpose is to create a first stepping stone to the topic. Our main goal is to address the fundamental question, what is AI—where are we now, how did we get here and where are we going—from economic, societal, and technical perspectives. In this chapter, we seek to differentiate between AI conceptualizations, applications, and technologies by creating a summary of the parallel histories of the concept and discussing the lenses through various theoretical paradigms seek to understand AI.