bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДЕРЖАВНІ БОРГОВІ ІНСТРУМЕНТИ У ФІНАНСОВО-КРЕДИТНІЙ СИСТЕМІ УКРАЇНИ
Authors: Levandivskyi O.T. , Plets I.I. , Krykhovetska Z.M. 
Published: July 2023

Актуальність теми дослідження супроводжується важливістю узагальнення та наукового обґрунтування певних аспектів функціонування боргових фінансових інструментів в Україні та у сучасних загальносвітових процесах з метою винесення уроків і окреслення подальших завдань діяльності фондового ринку. Метою дослідження є визначення сутності та особливостей розвитку ринку державних боргових цінних паперів, аналіз тенденцій його розвитку, проблем функціонування та визначення можливих перспектив його розвитку.
Державні боргові цінні папери є провідним інструментом, який використовує держава для залучення коштів на розвиток інфраструктури, соціальні програми, інші бюджетні витрати. Крім того, державні боргові інструменти є важливим елементом для розвитку ринку цінних паперів в Україні, який сприяє створенню нових можливостей для інвесторів та забезпечує збільшення ліквідності фінансового ринку в цілому. Український ринок державних боргових зобов’язань з часів незалежності проходив шість етапів свого розвитку. Перший етап характеризується початком зародження ринку у 1994-1995 роках, другий етап характеризує стрімкий рпозвиток протягом 1996-1997 рр. Третій етап пов'язаний з погіршенням стану ринку через світову кризу 1998 року. Четвертий етап характеризується процесами трансформації та реструктуризації 1999-2000 рр. Для п’ятого етапу характерним є формування нової моделі ринку державних боргових зобов’язань протягом 2001 - 2007 рр. На шостому етапі, що розпочався з 2008 року, спостерігалося значне зростання ринку ОВДП.
Розглянуто проблеми, які виниками в період становлення, формування та розвитку ринку державних боргових зобов’язань в Україні.
Проаналізована динаміка розміщення ОВДП на первинному ринку в 2011-2022 рр , зокрема розміщення військових ОВДП в Україні. Розглянуто види ОЗДП України, що знаходяться в обігу. Розглянуто практику випуску державних боргових цінних паперів країнами світу на даний час, зокрема урядом Польщі, США, Німеччини, Японії, Європейською комісією.
На основі поведеного дослідження визначено напрями вдосконалення функціонування ринку державних боргових цінних паперів. Серед них: запровадження інноваційних продуктів, розвиток міжнародної кооперації, інструментів державно-приватного партнерства для фінансування державних проектів та програм.
Levels of oxidative stress and apoptosis-related biomarkers in endometriosis
Authors: ÜLGER ÖZBEK Dilara , KARAKUŞ Savaş , BAKIR Sevtap 
Published: July 2023

Purpose: In this study, the apoptosis marker M30, the oxidative stress markers malondialdehyde, (MDA) and asymmetric dimethyl arginine (ADMA) have been studied in the context of endometriosis.
Materials and Methods: This prospective case-control study comprises 31 patients diagnosed with endometriosis and 31 controls. ADMA and M30 levels in blood serum were measured by the enzyme-linked immunosorbent assay (ELISA) method, and MDA levels were measured by the spectrophotometric method. In addition, some biochemical parameters and cancer antigen-125 (CA-125) levels were also measured.
Results: M30 levels were statistically lower in endometriosis patients (271.5 IU/L) than in controls (371.3 IU/L). ADMA levels were higher in endometriosis patients (19.3 ng/L) compared to controls (12.7 ng/L). CA-125 levels were statistically higher in the endometriosis patients (65.1 U/mL) compared to the controls (19.0 U/mL). There was no significant difference between the two groups in MDA levels. The results regarding dyspareunia, pelvic pain, AST, and ALP were statistically significant.
Conclusion: In our study, decreased M30 levels in the patient group were associated with reduced apoptosis in endometriosis. ADMA levels, elevated with the increase of oxidative stress, were higher in the patients. MDA levels, an indicator of increased oxidative stress, were also higher in the patient group. This study constitutes the first data regarding endometriosis patients' ADMA, M30, and MDA levels.
The impact of communication on patients\' satisfaction with quality of nursing care: A study of hospitalized patients in Uttar Pradesh, India
Authors: Kumar Nitish , Sharma Neeraj  Kumar 
Published: July 2023

Patient satisfaction is used as an outcome criterion and a standard tool for evaluating the level of nursing care provided. This study aimed to determine how satisfied hospitalized patients were with the quality of their nurses' care.An N=499 and an N=899 sample size group were used in a descriptive cross-sectional study of hospital-based medical treatment. Also, patients' ratings on the quality of their mental treatment were determined. Mean, standard deviation, t-test, and analysis of variance were calculated.The results indicate a mean value of 3.5, a standard deviation of 1.61, and a variance value of 1.269 and a margin of error 0.401 for this patient study. Those admitted to medical wards for treatment were the most pleased with the level of nursing care they got. It became clear from the data that there is room for development in the area of communication. The level of patient satisfaction with their nursing treatment was not correlated with any demographic or clinically relevant factors.
Ideologia w edukacji. Spojrzenie opisowe, negatywne i pozytywne na przykładzie wybranych stanowisk pedagogiki katolickiej i krytycznej
Authors: Kruszelnicki Wojciech 
Published: July 2023

W artykule dokonuje się porównania interpretacji pojęcia ideologii w badaniach edukacyjnych uprawianych przez niektórych uczonych katolickich z jego problematyzacją na gruncie świeckich, niekościelnych — zarówno krajowych, jak i zagranicznych — studiów edukacyjnych. Pojęciem centralnym jest tu ideologia, która według wybranych do polemiki badaczy katolickich w różnych postaciach infekuje nauki o wychowaniu; standardowo kojarzona jest przy tym z zafałszowaniem rzeczywistości, myśleniem utopijnym oraz indoktrynacją edukacyjną. Artykuł demonstruje niedostatki dogmatyczno-katolickiego ujęcia ideologii i pokazuje jego niezgodność z filozoficznie ugruntowanymi ujęciami zarówno ze strony pedagogów świeckich, jak i ze strony bardziej progresywnych badaczy katolickich. Autor argumentuje, że aby myśleć o ideologii edukacyjnej w prawdziwie nowoczesny i krytyczny sposób, nie można trzymać się dogmatycznych nauk Kościoła, lecz należy wziąć pod uwagę także opisowe oraz pozytywne — istotne dla pedagogiki — znaczenie tej kategorii, tak jak ma to miejsce w dyskursie pedagogiki krytycznej.
Teologiczne konsekwencje darwinizmu — „Bóg Darwina” Corneliusa G. Huntera
Authors: Gołaszewski Filip 
Published: July 2023

Celem tego artykułu jest przedstawienie teodycei Darwinowskiej według Corneliusa G. Huntera. Książka Huntera została przetłumaczona na język polski przez Józefa Zonia i wydana przez Fundację En Arche w 2021 roku. Artykuł przedstawia krytyczną lekturę książki Huntera. Twierdzi się, że główna teza Huntera jest powierzchowna, a argumenty na jej poparcie są niewystarczające. Po pierwsze, przedstawiono historyczne tło problemu teodycei. Począwszy od św. Augustyna i Leibniza, omawiane są niektóre XX-wieczne i współczesne próby rozwiązania problemu zła. W ten sposób nakreślony zostaje kontekst dla podjętej przez Huntera próby przedstawienia Darwinizmu jako przykładu filozoficznej teodycei. Po drugie, przedstawione są główne idee książki Huntera Bóg Darwina. Szczególny nacisk położony jest na problem metafizycznych i teologicznych implikacji, ale także ukrytych założeń stojących za teorią ewolucji. W zakończeniu artykułu uwypuklone zostały pewne słabości narracji Huntera na temat kulturowych źródeł Darwinowskiego deizmu. Zwrócono uwagę na historyczne uproszczenia dotyczące dziewiętnastowiecznego ateizmu oraz logiczną lukę w argumentacji Huntera. Hunter argumentuje, że Darwinizm opiera się na określonych metafizycznych założeniach i z tego powodu nie może być uważany za przykład nauki. Jednocześnie Hunter nie podaje przykładu teorii naukowej, która byłaby całkowicie wolna od metafizycznych założeń. Wydaje się zatem, że jego krytyka Darwinizmu nie dostarcza przekonujących argumentów.
Cyclic pulse loads pave the road to the GRIP concept in abdominal wall reconstruction
Authors: Lesch Carolin , Ludwig Yannique , Kugel Fabio , Uhr Katharina , Vollmer Matthias , Nessel Regine , Kallinowski Friedrich 
Published: July 2023

Aim : Durable reconstruction of the abdominal wall needs to be assessed in a lifelike experimental setting and consider the reconstructed abdominal wall as a coherent compound. Our aim was to evaluate broader possibilities in preclinical testing and to deepen the understanding of the biomechanical influences.
Methods : We developed a test bench that allows studying a compound under cyclic, repetitive loads. Pulse loads transmit energy to the abdominal wall repeatedly. The amount of energy is related to the load characteristics. We used porcine bellies with a round central (5 cm) defect. They were bridged in a sublay position with Cicat Dynamesh®. Further defects, located in an additional incision, were sutured in a standardized small-bite technique. We varied the number of loads, the maximum peak pressure, the pressure plateau length, and the impact area size.
Results : Increasing the peak pressure by 30 mmHg lowers the durability by about 20 %. Prolonging the plateau phase led to a significant durability decrease. During the first 100 dynamic intermittent strain (DIS) impacts, the major tissue deformation and the majority of failures occur. Beyond the 425th DIS impact, about 10 % more failures occur. Increasing elongation and deformation of the tissue raise the likelihood of failure.
Conclusion : If the compound does not establish a strain-stable condition during the period of plastic deformation, failure occurs. The outcome does not only depend on the reconstruction technique but also on the external influences acting on the abdominal wall compound. Considering the biomechanical reality is important for open and minimally invasive abdominal wall reconstruction.
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease
Authors: Hackenhaar Fernanda Schäfer , Josefsson Maria , Adolfsson Annelie Nordin , Landfors Mattias , Kauppi Karolina , Porter Tenielle , Milicic Lidija , Laws Simon M. , Hultdin Magnus , Adolfsson Rolf , Degerman Sofie , Pudas Sara 
Published: July 2023

Abstract
Background: DNA methylation (DNAm), an epigenetic mark reflecting both inherited and environmental influences, has shown promise for Alzheimer’s disease (AD) prediction.
Objective: Testing long-term predictive ability (>15 years) of existing DNAm-based epigenetic age acceleration (EAA) measures and identifying novel early blood-based DNAm AD-prediction biomarkers.
Methods: EAA measures calculated from Illumina EPIC data from blood were tested with linear mixed-effects models (LMMs) in a longitudinal case-control sample (50 late-onset AD cases; 51 matched controls) with prospective data up to 16 years before clinical onset, and post-onset follow-up. Novel DNAm biomarkers were generated with epigenome-wide LMMs, and Sparse Partial Least Squares Discriminant Analysis applied at pre- (10-16 years), and post-AD-onset time-points.
Results: EAA did not differentiate cases from controls during the follow-up time (p-values>0.05). Three new DNA biomarkers showed in-sample predictive ability on average 8 years pre-onset, after adjustment for age, sex, and white blood cell proportions (p-values: 0.022-< 0.00001). Our longitudinally-derived panel replicated nominally (p=0.012) in an external cohort (n=146 cases, 324 controls). However, its effect size and discriminatory accuracy were limited compared to APOEε4-carriership (OR=1.38 per 1 SD DNAm score increase vs. OR=13.58 for ε4-allele carriage; AUCs=77.2% vs. 87.0%). Literature review showed low overlap (n=4) across 3275 AD-associated CpGs from 8 published studies, and no overlap with our identified CpGs.
Conclusions: The limited predictive value of EAA for AD extends prior findings by considering a longer follow-up time, and with appropriate control for age, sex, APOE, and blood-cell proportions. Results also highlight challenges with replicating discriminatory or predictive CpGs across studies.
Differences in hyporheic water exchange in habitats of different aquatic Ranunculus species – case study in Poland
Authors: Marciniak Marek , Gebler Daniel , Grygoruk Mateusz , Zalewska-Gałosz Joanna , Szoszkiewicz Krzysztof 
Published: July 2023

Abstract
Hyporheic water exchange driven by groundwater-surface water interactions constitutes habitat conditions for aquatic biota. In our study we conducted field-research-based analysis of hyporheic water exchange to reveal whether the hyporheic water exchange differentiates particular Ranunculus sp. habitats. We measured the density of stream filtration and vertical gradients of water residing in the hyporheic zone. We revealed that R. peltatus and R. penicillatus persist in habitats of considerably higher hyporheic water exchange draining flux (respectively 0.0852 m3/d/m2 and 0.0952 m3/d/m2) than R. circinatus, R. fluitans and a hybrid of R. circinatus x R. fluitans (respectively 0.0568 m3/d/m2; 0.0222 m3/d/m2 and 0.0717 m3/d/m2). Presented results can be used as an indicator of aquatic habitats suitability in the case of protection and management of ecosystems settled by Ranunculus sp.
Protein arginine methyltransferase 5 (PRMT5) is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer
Authors: Lin Chang-Ching , Chang Tsung-Cheng , Wang Yunguan , Guo Lei , Gao Yunpeng , Bikorimana Emmanuel , Lemoff Andrew , Fang Yisheng , Zhang He , Zhang Yanfeng , Ye Dan , Soria-Bretones Isabel , Servetto Alberto , Lee Kyung-min , Luo Xuemei , Otto Joseph , Akamatsu Hiroaki , Napolitano Fabiana , Mani Ram , Cescon David , Xu Lin , Xie Yang , Mendell Joshua , Hanker Ariella , Arteaga Carlos 
Published: July 2023

Abstract
CDK4/6 inhibitors (CDK4/6i) have improved survival of patients with estrogen receptor-positive (ER+) breast cancer. However, patients treated with CDK4/6i eventually develop drug resistance and progress. RB1 loss-of-function alterations confer acquired resistance to CDK4/6i, but the optimal therapy for these patients is unclear. Using a genome-wide CRISPR screen, we identified protein arginine methyltransferase 5 (PRMT5) as a molecular vulnerability in ER+/RB1-knockout (RBKO) breast cancer cells. PRMT5 inhibition blocked cell cycle G1-to-S transition independent of RB, thus arresting growth of RBKO cells. Proteomics analysis uncovered fused in sarcoma (FUS) as a downstream effector of PRMT5. Pharmacological inhibition of PRMT5 resulted in dissociation of FUS from RNA polymerase II (Pol II), Ser2 Pol II hyperphosphorylation, and intron retention in genes that promote DNA synthesis. Treatment with the PRMT5i inhibitor pemrametostat and fulvestrant synergistically inhibited growth of ER+/RB-deficient patient-derived xenografts, suggesting dual ER and PRMT5 blockade as a novel therapeutic strategy to treat ER+/RB-deficient breast cancer.
Optimal selection of a sustainable alternative-fueled commercial vessel engine using multi-attribute decision-making
Authors: Kim Kyungrok 
Published: July 2023

Abstract
Various green seaborne transportation strategies, which minimize the impact of climate and economic losses on shipping, are used in the maritime industry. This study aimed to determine an optimal alternative fuel by measuring and evaluating four alternative marine fuels—liquefied natural gas (CH4), H2, NH3, and MeOH—in terms of sustainability using a multi-attribute decision-making methodology. These were ranked through life cycle sustainability assessments: environmental life cycle assessment, life cycle cost and net present value, and social life cycle assessment. The energy system model showed that in all assessments, the CH4-internal combustion engine (ICE) outperformed the other alternatives. The analysis also revealed that alternative fuel technologies were inferior when considering environmental, economic, and social multi-criteria evaluations. Because CH4 is technologically feasible, CH4-fueled ships have been commercialized and their infrastructure for extraction, storage, delivery, and use have become well-established along major routes. However, CH4 is a fossil fuel, and events such as oil shocks can recur because of regulations in countries with sizable natural gas reserves. Therefore, the technological development of H2-ICE, H2-solid oxide fuel cell (SOFC), and MeOH-SOFC, which are the most suitable technologies together with CH4, is essential.
Repression of ferroptotic cell death by mitochondrial calcium signaling
Authors: Wen Haitao , Chen Jianwen , Zhao Bao , Wang Shen , Ma Anjun , Dong Hong , Cheng Xiang , Lin Shengyin , Li Xinghui , Herring Laura , Xin Gang , Ma Qin , He Kai , Xie Ruili , Lei Yu , ingold Irina , Cheng Xiaolin , Li Zihai 
Published: July 2023

Abstract
The uptake of Ca2+ into and extrusion of calcium from the mitochondrial matrix, regulated by the mitochondrial Ca2+ uniporter (MCU), is a fundamental biological process that has crucial impacts on cellular metabolism, signaling, growth and survival. Herein, we report that the embryonic lethality of Mcu-deficient mice is fully rescued by orally supplementing ferroptosis inhibitor lipophilic antioxidant vitamin E and ubiquinol. Mechanistically, we found MCU promotes acetyl-CoA-mediated GPX4 acetylation at K90 residue, and K90R mutation impaired the GPX4 enzymatic activity, a step that is crucial for ferroptosis. Structural analysis supports the possibility that GPX4 K90R mutation alters the conformational state of the molecule, resulting in disruption of a salt bridge formation with D23, which was confirmed by mutagenesis studies. Finally, we report that deletion of MCU in cancer cells caused a marked reduction in tumor growth in multiple cancer models. In summary, our study provides a first direct link between mitochondrial calcium level and sustained GPX4 enzymatic activity to regulate ferroptosis, which consequently protects cancer cells from ferroptosis.
Leveraging Marine Predators Algorithm with Deep Learning Object Detection for Accurate and Efficient Detection of Pedestrians
Authors: Gogineni Hima Bindu , Bhuyan Hemanta Kumar , Lydia Laxmi 
Published: July 2023

Abstract
Pedestrian detection using object detection and deep learning has been found to be effective method for identifying pedestrians in video frames or images accurately. It is more commonly used in many real-time applications, such as security observing systems, autonomous driving systems, and robotics. The combination of deep learning techniques and object detection algorithms allows efficient and robust detection of pedestrians in several real-time scenarios. But it is necessary to improve the detection efficacy for complex environments such as cases with worse visibility due to weather or daytime, crowd scenes, and rare pose samples. Continuous improvement and research in DL algorithms, dataset collection, and training models contribute to accelerating the robustness and accuracy of pedestrian detection systems. Therefore, this study designs a new marine predator algorithm with deep learning-based pedestrian detection and classification (MPADLB-PDC) technique. The objective of the MPADLB-PDC approach lies in the accurate recognition and classification of pedestrians. To achieve this, the MPADLB-PDC technique involves two major processes, namely object detection and classification. In the first stage, the MPADLBPDC technique uses an improved YOLOv7 object detector for the recognition of the objects in the frame. Next, in the second stage, the ensemble classifier comprises three classifiers such as deep feed-forward neural network (DFFNN), extreme learning machine (ELM), and long short-term memory (LSTM). To improve the recognition performance of the ensemble classifier, the MPA is used to optimally select the parameters related to it. The simulation outcome of the MPADLB-PDC system was validated on the pedestrian database, and the outcome can be studied interms of various aspects. The simulation values validated the better outcome of the MPADLB-PDC system compared to other approaches.
Effect of probiotics on honeymoon period duration and glycemic control of type one diabetes mellitus: A randomized controlled double blind clinical trial study protocol
Authors: moazzen nasrin , ghaemi nosrat , ahanchian hamid , nikpour sara , Bagheri Sepideh 
Published: July 2023

Abstract
Background
type 1 diabetes is one of the most chronic diseases of childhood. The therapeutic recommendation for this condition is quite complex and needs changes in lifestyle. Recently the role of gut microbiota has received attention as a possible mechanism in the pathogenesis and control of the disease.
Methods
One hundred thirty Children aged 6–18 years old with newly diagnosed diabetes type one participate in the trial they are randomly assigned to the intervention or control group. The patients will receive a six month course of probiotics or placebo besides their conventional treatment with insulin. And they will be followed for at least one year. Participants are followed at 3 month intervals for one year. At each visit anthropometrical data, glycemic control and total dose of insulin required to keep the optimal glycemic control is evaluated and registered.
Discussion
There is evidence that alterations in gut microbiota is seen in children with diabetes. In this study we aim to evaluate the effect of probiotic administration on the duration of honeymoon period in pediatrics with type one diabetes and their glycemic control and insulin requirements.
Clinical trial registration: IRCT20200117046164N3
System analysis based on the necroptosis-related genes in heart failure
Authors: Kong Yiya , Guo Ying , Xu Tao , Zhou Jihong , Wang Fang 
Published: July 2023

Abstract
Background: Heart failure(HF) is an emerging epidemic clinical syndrome that remains a leading cause of global morbidity and mortality. This study aimed to determine necroptosis' role in HF using bioinformatics analyses.
Methods: A total of 3 datasets, including myocardial tissues samples from 225 HF patients and 26 normal people, were acquired from the Gene Expression Omnibus (GEO). Necroptosis-related differentially expressed genes (NRDEGs) in HF were determined. A prediction model based on three NRDEGs were constructed to assess the risk of HF. Then, consensus clustering, protein-protein interactions (PPI), and identifying the top 10 hub genes were performed. The Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) were carried out. Investigations were conducted into immune infiltration. Furthermore, the eight NRDEGs’ mRNA expression level was validated in blood samples by quantitative real time-PCR (RT-qPCR).
Results:
A total of eight NRDEGs, namely FLOT1, DAPK1, KLHDC10, FLOT2, FAS, UCHL1, TNFAIP3, HSPA5, were excavated and further verified by RT-qPCR in blood samples. The expression levels of TNFAIP3 and HSPA5 were lower in HF, consistent with bioinformatics analysis. The correlation analysis revealed the regulatory network between 51 NRGs. The HF risk prediction model constructed of FLOT2, FAS and FLOT1 has relatively good accuracy and reliability. The 10-hub-genes associated with necroptosis might be significantly related to HF. Among10-hub-genes, STIP1, TGFBR2, and HSPD1 might be potential markers to indicate the early stage or progression of HF. The GSEA clarified nine relevant enrichment pathways.
Conclusion: Our research supplies new information and views for investigating the underlying necroptosis-related mechanism and possible treatments of HF.