bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Klinis dan Proporsi Hipotiroidisme Sekunder pada Pasien Adenoma Hipofisis di Rumah Sakit Cipto Mangunkusumo
Authors: Cahyanur Rahmat , Soewondo Pradana , Darmowidjojo Budiman , Aman Renindra Ananda , Dewiasty Esthika 
Published: February 2023

Pendahuluan: Adenoma hipofisis merupakan tumor yang berasal dari jaringan hipofisis anterior. Manifestasi klinis timbul akibat pendesakan massa dan gangguan sekresi hormon. Salah satu gangguan hormonal yang ditimbulkan adalah hipotiroidisme sekunder. Hipotiroidisme sekunder terkait dengan penurunan kualitas hidup serta peningkatan risiko kardiovaskular.
Tujuan: Mengetahui proporsi hipotiroidisme sekunder dan gambaran klinis pasien adenoma hipofisis.
Metode: Penelitian ini adalah studi potong lintang. Data diambil dari rekam medis pasien di Rumah Sakit Cipto Mangunkusumo antara tahun 2007-2012. Data demografis (usia, jenis kelamin), karakteristik klinis, jenis adenoma, data radiologis, pemeriksaan hormon (T4 bebas dan TSH) dievaluasi pada peneltian ini.
Hasil: Terdapat 45 pasien yang memenuhi kriteria penelitian ini. Sebagian besar subyek adalah wanita (62,2%). Keluhan utama subyek adalah gangguan penglihatan (55,6%). Gejala yang sering ditemukan adalah sakit kepala (86,7%), gangguan penglihatan (77,8%). Pada subyek wanita manifestasi yang pertama kali muncul adalah gangguan penglihatan dan gangguan fungsi seksual (39,3% dan 32,1%). Pada Usia muda, gejala pertama kali muncul lebih pada kelompok adenoma fungsional dibandingkan non fungsional (32,9 vs. 40,6). Hampir seluruh kasus yang ditemukan adalah makroadenoma (97,8%). Proporsi subyek yang mengalami hipotiroidisme sekunder adalah 40%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan dan gangguan ereksi.
Kesimpulan: Gangguan penglihatan adalah keluhan utama yang sering ditemukan. Pada subyek wanita, keluhan gangguan fungsi seksual bersama dengan gangguan penglihatan adalah manifestasi yang pertama kali muncul. Proporsi hipotiroidisme sekunder pada penelitian ini adalah 40,0%. Subyek dengan hipotiroidisme sekunder lebih banyak mengeluhkan gangguan penglihatan, gangguan ereksi.
Six Minute Walking Distance Cut-off Point in Indonesian (Mongoloid) Population
Authors: Nusdwinuringtyas Nury 
Published: February 2023

Introduction: Six-minute walk test has been a recommended valid and reliable tool used for functional capacity assessment. American Thoracic Society (ATS) had stated that there are no global standards in interpreting 6-minute walking distance (6MWD) as a one-time measurement of functional assessment, which may be caused by population differences and various 6MWT technique utilized in previous studies. Single time cut off is required to evaluate functional status at the start of a program as a baseline for further follow-up evaluations. It is then a necessity to determine these cut off points in every country/race.
Methods: The study was performed on healthy subjects, sedentary lifestyle, age 18-50, Indonesian ethnicity (Mongoloid race). Recorded data were 6 minute walking distance,also body height and weight. Predicted walking distance based on gender is obtained by calculating walk distance, body weight, body height, gender and subject age in Nury’s predicted walk distance formula. Data is analysed with SPSS 20, utilizing independent T-test.
Results: As much as 123 subjects (58 males, 65 females) were included in this study. Mean walking distance for males is 581,98 meters, while females are 516,80 meters, and these differences were statistically significant. Walking distance cut off point between gender were compared. In male subjects, actual walking distance were taken as normalif >483 meters, poor if 434-483 meters, and very poor <434 meters. As for female subjects, normal when >442 meters, poor when 405-442 meters, and very poor in distance <405 meters. General percentage cut off point in comparison to predicted walking distance was categorized into normal, poor and very poor subgroups. Normal percentage was >85%, poor when distance is 77-85%, and <77% categorized as very poor.
Conclusion: There are varying cut off points for walking distance in both males and females. Percentage cut off point as compared to predicted walking distance were not differentiated between genders.
Clinical and Graft Survival Characteristics of Optical Penetrating Keratoplasty at a Tertiary Care Center in Indonesia: A 4-Years Retrospective Study
Authors: Widyawati Syska , Gondhowiardjo Tjahjono D. , Nora Rina La Distia , Harniza Yulika , Samira Cut Putri , Alberta Ivana Beatrice 
Published: February 2023

Introduction: Purpose, to evaluate patient demographic characteristics, indications and variables related to penetrating keratoplasty (PK) survival. Study design, this study was retrospective case series.
Methods: We trace all medical records of PK patients from 2015 to 2018 in Cipto Mangunkusumo Hospital Jakarta. The traced variables were indications of surgery, corneal vascularization, previous failed graft, glaucoma after PK, and other complication. PK survival rate is shown in the Kaplan Meier curve using SPSS v20.0.
Results: A total of 214 patients underwent PK (men 67.3%, woman 32,7%) with mean age of 42.11 (0-85) years were included in this study. Three most common indications of keratoplasty were corneal scar (32.7%), infectious corneal ulcer (25.5%), and failed graft (19.2%). The overall graft survival rate for PK is 61.7%. The mean graft survival time was 14.388 ± 0.580 months (95% CI; 13.252-15.524).
Conclusion: The graft survival rate for penetrating optic keratoplasty was 61.7%. Establishing an appropriate early diagnosis, reasonable surgical procedures, close monitoring, and early detection of complications with proactive interventions lead to better outcomes. Further research is needed to determine the relationship between the risk factors for corneal graft failure.
Cognitive Behavioral Therapy in a Newly Diagnosed COVID-19 Patient with Insomnia due to Adjustment Disorder: A Case Report
Authors: Surya Michael , Purnama Dharmawan Ardi 
Published: February 2023

Background: COVID-19 patients are reported suffering from anxiety, depression, and stress which culminates in the form of insomnia, and becomes a typical comorbid in hospitalized patients. Sedative-hypnotic drugs usually used to treat insomnia may not provide a viable solution as it has inhibitory effects on the respiratory system. Previous research suggested that one-week Cognitive Behavioral Therapy improved sleep latency, night sleep time, and sleep efficiency of COVID-19 patients with insomnia.
Case: A case of 53-year-old female patient with moderate symptoms of COVID-19 suffered from sleeping problems was diagnosed with insomnia due to adjustment disorder. She was given medication for three days and was scheduled for one hour of cognitive behavioral therapy intervention everyday. CBT intervention also included scheduling a regular daily activity and sleep hygiene programme.
Result: There was no improvement from medication administered to help in relieving the insomnia symptoms. However, the patient was more able to sleep well on the sixth day of treatment, after five daily sessions of CBT, which was three days after stopping the medication.
Conclusion: These results confirmed the effectiveness of daily CBT in improving the patient’s sleep quality and efficiency after one week, as suggested by previous studies.
Optimalaisasi Peran dan Fungsi Pemerintahan Desa di Kabupaten Bolaang Mongondow Selatan
Authors: Madjid Ramli , Tahir Arifin , Dunggio Titin 
Published: February 2023

The objectives of this research are: (1) Knowing and analyzing the optimization of the roles and functions of village government. (2) Knowing and analyzing the factors that determine and hinder the optimization of the role and function of the village government.
This research is a research with a qualitative descriptive approach, namely examining, analyzing and decrypting the data.
The informants in this study were 33 people consisting of: Camat, District Secretary, Head of BPD, Sangadi, Village Secretary, Head of Financial Affairs, and Head of Government Section.
Research Results: (1) The roles and functions of local government have been optimal. For the role of the village government in the implementation of government in the village, both as a dynamist, catalyst, and pioneer, it has been going well or has been optimal based on the results of interviews that have been conducted. Meanwhile, the function of the village government is in development planning, village government administration; and Village financial management, has been running well or has been optimal based on the results of interviews that have been conducted; (2) Government policy factors that most influence the optimization of village government roles and functions, with the consideration that human resources (apparatus), budget (finance), facilities and infrastructure all depend on government policies (central, provincial and district).
Suggestions: (1) In order to optimize the roles and functions of the village government, a higher quality of human resources is needed. (2) The government can provide future policies regarding the functions and roles of village government.
The Strategy of Gorontalo Police Service in Improving Community Vaccination Discipline in the Era of the Covid-19 Pandemic
Authors: Daud Ahmad rizak , Arifin Tahir  , Djamila Podungge  
Published: February 2023

This study aims to determine and analyze the strategy of Gorontalo Police Service in improving community vaccination discipline in the Covid-19 pandemic era.
This type of research is descriptive qualitative. Data collection techniques through interviews, observation and documentation studies. Data analysis techniques through data reduction, data presentation, and data verification.
The results showed that the strategy of Gorontalo Police Service was running well through the Determination of Service Standards, Information and Openness, Preference and Counseling, Leading Personnel Practices, Effective Complaints Unit, Use of Information and Communication Technology. The strategy of Gorontalo Police Service has been able to improve community vaccination discipline in the Covid-19 pandemic era, but daily achievements have not met the expected target. Constraints faced 1) Limited human resources, 2) Lack of mobilization facilities, 3) Lack of public awareness for vaccination. It is recommended that the Gorontalo Police Resources Department carry out technical guidance on an ongoing basis for the management and administration of Covid-19 vaccination services in Gorontalo Regency. People who have received vaccinations are expected to remain disciplined in maintaining the 5M health protocol, washing hands, wearing masks, maintaining distance, avoiding crowds and limiting mobility. People who have not received vaccinations are expected with self-awareness to immediately go to referral places to get vaccination services
Safety and efficacy of eye drops from umbilical cord blood platelet lysate to treat resistant corneal ulcer
Authors: Farag Rania Kamel , Dawood Mervat , Elesawi Maher 
Published: February 2023

Background: Umbilical cord blood (UCB) is a novel treatment of resistant corneal ulcers owing to the unique anti-inflammatory molecules and growth factors it contains. Platelet lysates are a potential future alternative. The aim of the present study was to assess the role of human UCB platelet lysate in treating resistant corneal ulcers.
Methods: This was prospective, non-comparative, interventional case series involving 40 eyes of patients aged 6 – 65 years with persistent corneal ulcers from the Mansoura Ophthalmic Center and Mansoura Research Center for Cord Stem Cells. Patients were classified according to the cause of persistent corneal ulcer into four groups: group I, including 14 eyes with dry eye disease; group II, including six eyes post-keratoplasty; group III, including four eyes with corneal chemical burn; and group IV, including 16 eyes with persistent corneal ulcer from other causes. All participants underwent detailed ophthalmic examinations, and baseline and final best-corrected distance visual acuity (BCDVA) were recorded. Eye drops were prepared from UCB platelet lysate and administered to all patients along with detailed meticulous instructions for the method of use. Clinical progression of wound healing was continuously observed. The treatment response was identified as complete healing, improvement, or treatment failure.
Results: BCDVA improved significantly in all studied groups (all P < 0.05). In group I, complete healing, improvement, and treatment failure occurred in 71%, 29%, and 0% of cases. In group II, complete healing, improvement, and treatment failure occurred in 67%, 33%, and 0% of cases. In group III, complete healing, improvement, and treatment failure occurred in 50%, 50%, and 0% of cases. In group IV, complete healing, improvement, and treatment failure occurred in 63%, 12%, and 25% of cases. No adverse events associated with the treatment were observed or subjectively self-reports in the study period.
Conclusions: Eye drops from UCB platelet lysate were a novel therapeutic blood component with unique growth factors and anti-inflammatory compounds that could be an effective and safe treatment option in managing persistent corneal ulcers of different causes. A future randomized clinical trial with a large sample size and a longer follow-up is required to confirm these preliminary outcomes.
The CALIPSO version 4.5 stratospheric aerosol subtyping algorithm
Authors: Tackett Jason L. , Kar Jayanta , Vaughan Mark A. , Getzewich Brian J. , Kim Man-Hae , Vernier Jean-Paul , Omar Ali H. , Magill Brian E. , Pitts Michael C. , Winker David M. 
Published: February 2023

Abstract. The accurate classification of aerosol types injected into the stratosphere
is important to properly characterize their chemical and radiative impacts
within the Earth climate system. The updated stratospheric aerosol subtyping
algorithm used in the version 4.5 (V4.5) release of the Cloud Aerosol Lidar
with Orthogonal Polarization (CALIOP) level 2 data products now delivers
more comprehensive and accurate classifications than its predecessor. The
original algorithm identified four aerosol subtypes for layers detected
above the tropopause: volcanic ash, smoke, sulfate/other, and polar
stratospheric aerosol (PSA). In the revised algorithm, sulfates are
separately identified as a distinct, homogeneous subtype, and the diffuse,
weakly scattering layers previously assigned to the sulfate/other class are
recategorized as a fifth “unclassified” subtype. By making two structural
changes to the algorithm and revising two thresholds, the V4.5 algorithm
improves the ability to discriminate between volcanic ash and smoke from
pyrocumulonimbus injections, improves the fidelity of the sulfate subtype,
and more accurately reflects the uncertainties inherent in the
classification process. The 532 nm lidar ratio for volcanic ash was also
revised to a value more consistent with the current state of knowledge. This
paper briefly reviews the previous version of the algorithm (V4.1 and V4.2)
then fully details the rationale and impact of the V4.5 changes on subtype
classification frequency for specific events where the dominant aerosol type
is known based on the literature. Classification accuracy is best for volcanic
ash due to its characteristically high depolarization ratio. Smoke layers in
the stratosphere are also classified with reasonable accuracy, though during
the daytime a substantial fraction are misclassified as ash. It is also
possible for mixtures of ash and sulfate to be misclassified as smoke. The
V4.5 sulfate subtype accuracy is less than that for ash or smoke, with
sulfates being misclassified as smoke about one-third of the time. However,
because exceptionally tenuous layers are now assigned to the unclassified
subtype and the revised algorithm levies more stringent criteria for
identifying an aerosol as sulfate, it is more likely that layers labeled as
this subtype are in fact sulfate compared to those assigned the sulfate/other
classification in the previous data release.
Bayesian transdimensional inverse reconstruction of the Fukushima Daiichi caesium 137 release
Authors: Dumont Le Brazidec Joffrey , Bocquet Marc , Saunier Olivier , Roustan Yelva 
Published: February 2023

Abstract. The accident at the Fukushima Daiichi nuclear power plant (NPP) yielded massive and rapidly varying atmospheric radionuclide releases.
The assessment of these releases and of the corresponding uncertainties can be performed using inverse modelling methods that combine an atmospheric transport model with a set of observations and have proven to be very effective for this type of problem.
In the case of the Fukushima Daiichi NPP, a Bayesian inversion is particularly suitable because it allows errors to be modelled rigorously and a large number of observations of different natures to be assimilated at the same time.
More specifically, one of the major sources of uncertainty in the source assessment of the Fukushima Daiichi NPP releases stems from the temporal representation of the source.
To obtain a well-time-resolved estimate, we implement a sampling algorithm within a Bayesian framework – the reversible-jump Markov chain Monte Carlo – in order to retrieve the distributions of the magnitude of the Fukushima Daiichi NPP caesium 137 (137Cs) source as well as its temporal discretization.
In addition, we develop Bayesian methods that allow us to combine air concentration and deposition measurements as well as to assess the spatio-temporal information of the air concentration observations in the definition of the observation error matrix. These methods are applied to the reconstruction of the posterior distributions of the magnitude and temporal evolution of the 137Cs release. They yield a source estimate between 11 and 24 March as well as an assessment of the uncertainties associated with the observations, the model, and the source estimate.
The total reconstructed release activity is estimated to be between 10 and 20 PBq, although it increases when the deposition measurements are taken into account.
Finally, the variable discretization of the source term yields an almost hourly profile over certain intervals of high temporal variability, signalling identifiable portions of the source term.
U tế bào Hürthle tuyến giáp trong trung thất - báo cáo trường hợp lâm sàng và xem xét tài liệu liên quan
Authors: Công Cung Văn 
Published: February 2023

Trong phân loại của tổ chức y tế thế giới, các u tuyến giáp bao gồm: (1) U tuyến giáp dạng keo (Colloidal thyroid tumor); (2) U nang tuyến giáp (Thyroid cyst); (3) U viêm tuyến giáp (Thyroid inflammatory tumor); (4) Bướu giáp đa nhân (Multinodular thyroid tumor); (5) U tuyến giáp hoạt động mạnh (Hyperactive thyroid tumor); (6) Ung thư tuyến giáp (Thyroid cancer). Một số tài liệu còn gọi nhóm 1 là nhóm u tuyến (Thyroid adenomas) và trong nhóm này phân típ tế bào Hürthle (Hürthle cell) được đặc biệt chú ý vì nó có thể tồn tại ở hai dạng lành tính (Hürthle cell adenoma - HCA) và ác tính (Hürthle cell carcinoma - HCC). Việc chẩn đoán phân biệt lành và ác tính luôn được đặt ra vì liên quan đến chiến lược điều trị và tiên lượng bệnh. Chúng tôi giới thiệu trường hợp bệnh HCA, trong trung thất, được chẩn đoán xác định và phẫu thuật thành công tại Bệnh viện Phổi Trung ương với mục tiêu nêu rõ phương cách tiếp cận chẩn đoán đồng thời nhấn mạnh phương pháp điều trị để các đồng nghiệp cùng tham khảo
Scattering light through temporal structure
Authors: Galiffi Emanuele 
Published: February 2023

A sufficiently fast temporal drive can induce a host of peculiar temporal scattering phenomena, such as the temporal analogues of spatial reflection and diffraction, but obeying different causal relations. In this talk I will present a number of theoretical advances and new ideas in this direction, as well as two series of recent experiments that are pioneering the growing field of temporal electromagnetic control.Firstly, I will demonstrate the first realization of electromagnetic time-diffraction, the temporal analogue of Young's famous double-slit experiment, performed in Indium Tin Oxide at near-optical frequencies, and discuss its implications for the microscopic study of non-equilibrium dynamics in transparent conducting oxides, as well as its potential applications for temporal light modulation and for the direct measurement of the temporal coherence of optical pulses. In the second part of the talk I will demonstrate the first observation of electromagnetic time-reflection, performed in a microwave waveguide, explaining why this phenomenon can be practically observed despite the recent claims of its unfeasibility, and I will show how this platform can be leveraged to achieve temporal coherent wave control, whereby a broadband pulse can be "instantaneously" erased or "sculpted" by means of an additional idler pulse, tailored to annihilate the first entirely or in part upon time-reflection.
Los vínculos comerciales de América Latina y el Caribe ante los riesgos de fragmentación geopolítica global
Authors: Campos Rodolfo , Timini Jacopo 
Published: February 2023

MotivaciónUna fragmentación geopolítica del comercio mundial, caracterizada por el surgimiento de dos bloques de países que restringen el comercio a los países que no pertenecen al mismo bloque, es un escenario que se ha vuelto más probable en los últimos tiempos. ¿Cómo afecta este riesgo geopolítico a las perspectivas comerciales y económicas de los países de América Latina y el Caribe?Ideas principales•Los países de América Latina y el Caribe difieren tanto en su grado de apertura comercial como en la composición geográfica de sus flujos comerciales.•Por lo tanto, presentan una exposición heterogénea al riesgo de una fragmentación del comercio por motivos geopolíticos.•Se cuantifica esta exposición por países y se analiza cómo América Latina puede aprovechar una mayor integración comercial con la Unión Europea para reducir los costes derivados de una eventual fragmentación del comercio internacional.
Modelos de gobernanza y continuidad en la empresa familiar
Authors: García Araoz Rodolfo , Lucero Bringas María de los Angeles 
Published: February 2023

El propósito de este artículo es presentar los resultados de la primera etapa de una investigación sobre los factores que afectan la continuidad de la empresa familiar. En esta etapa se realizó un estudio exploratorio, bajo un enfoque cualitativo, se hicieron lecturas y se condujeron entrevistas personales semi-directivas. Para el análisis de la información extraída se aplicaron técnicas de análisis cualitativos, especialmente el “análisis de contenido”. Como resultado se presentan cuatro hipótesis y un modelo integrador sobre la gobernanza de la empresa familiar. Se concluye que el modelo permite aumentar la comprensión de los factores que afectan la continuidad de la empresa familiar y que es un aporte necesario, que llena un espacio vacío, dado que la mayor parte de los conocimientos existentes son producto de estudios realizados en países económicamente desarrollados y con diferencias institucionales significativas con relación a las naciones latinoamericanas.