bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, tolerance, and pharmacokinetics of salvianolic acid B in healthy Chinese volunteers: A randomized, double-blind, placebo-controlled phase 1 clinical trial
Authors: Cheng Junlin , Long Jun , Zhang Jingjing , Han Le , Hu Yunfang , Liu Jianghui , Qiu Runze , Zhu Zhibin , Fan Hongwei 
Published: April 2023

Background: Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza Bunge. In China, many traditional Chinese medicines have been modified into injections for higher bioavailability and better efficacy. Salvianolic acid injection has been widely used in the clinic.Objective: This phase 1, randomized, double-blind, placebo-controlled, single-center study aimed to evaluate the safety, tolerance, and pharmacokinetics of Sal B injection in healthy Chinese volunteers.Methods: For the single-ascending-dose study, forty-seven healthy volunteers were randomly divided into 25, 75, 150, 200, 250, and 300 mg groups. For the multiple-ascending-dose study, sixteen healthy volunteers were randomly divided into 150 and 300 mg groups. In each group, volunteers were treated with Sal B or placebo randomly. Their safety was evaluated by a skin test, physical examination, vital sign, laboratory examination, 12-lead electrocardiogram, Holter, and clinical symptoms and signs. Blood samples were collected in 75, 150, and 300 mg single-ascending-dose study groups and 150 mg multiple-ascending-dose study groups to determine the concentration of salvianolic acid B.Results: In single-ascending-dose study groups, there were 41 adverse events in 24 cases (51.1%, 24/47). In multiple-ascending-dose study groups, there were 13 adverse events in eight cases (50.0%, 8/16). Sixty-six volunteers received the skin test, and three of them were excluded because of the positive result. Adverse events related to the treatment included increased alanine aminotransferase (4.0%), increased bilirubin (2.0%), increased creatinine kinase-MB (2.0%), increased brain natriuretic peptide (8.0%), increased urine N-acetyl-β-D-glucosidase (4.0%), dizziness (2.0%), and chest discomfort (2.0%). No serious adverse events occurred. No volunteers withdrew from the trial. Peak plasma concentration and the area under the plasma concentration–time curve of salvianolic acid B progressively increased in a dose-dependent manner in 75, 150, and 300 mg single-ascending-dose study groups. There was no accumulation after 5 consecutive days of administration of 150 mg salvianolic acid B.Conclusion: Salvianolic acid B injections administered up to 300 mg in a single dose and 250 mg for 5 consecutive days showed excellent safety and tolerability in healthy Chinese volunteers.Clinical Trial Registration:www.chinadrugtrials.org.cn, identifier CTR20192236
Effects of whole-body vibration training with different frequencies on the balance ability of the older adults: a network meta-analysis
Authors: Liu Peirong , Li Yongjie , Xiao Yajun , Li Duo , Liu Lin , Ma Yong , Zheng Weitao 
Published: April 2023

Purpose: To compare the effects of whole-body vibration training (WBVT) with different frequencies on the balance ability of older adults.Methods: Randomized controlled trials (RCTs) on the WBVT interventions on balance ability in older adults were searched through PubMed, Web of Science, The Cochrane Library, ProQuest, Embase, Opengrey, China National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal Database (CSTJ) databases from the establishment of the database to August 2022, and all literature that met the PICOS (Participants, Intervention, Comparison, Outcomes, Study design) criteria were enrolled. Two reviewers screened and assessed the methodological quality of the included literature according to the physiotherapy evidence database (PEDro) scale criteria. Statistical analysis was performed using Stata 14.0 software after data extraction.Results: Twenty-five RCTs with a total of 1267 subjects were finally included. The results of the pairwise comparison of the Network Meta-analysis showed that the Timed Up and Go Test (TUGT) values of Low-frequency whole-body vibration training (LF-WBVT) was lower than the placebo and traditional rehabilitation groups, and the difference was statistically significant [WMD = −1.37, 95% CI (−2.53, −0.20)] [WMD = −1.84, 95% CI(-3.17,-0.51)]. The Five-repetition Sit-to-Stand Test (5STS) values of LF-WBVT, Medium-frequency whole-body vibration training (MF-WBVT), and High-frequency whole-body vibration training (HF-WBVT) were lower than the placebo and traditional rehabilitation groups, but none of them were statistically significant. In addition, the TUGT and 5STS values of HF-WBVT had a tendency to be lower than those of LF-WBVT and MF-WBVT, but neither of them was statistically different. The cumulative probability ranking results of both TUGT and 5STS showed that HF-WBVT was the best protocol.Conclusion: Current evidence shows that HF-WBVT may be the best protocol for improving balance in older adults. Due to the study’s limitations, the conclusion obtained in this study still needs to be further confirmed by more high-quality studies.Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD42021250405].
Conserved hierarchical gene regulatory networks for drought and cold stress response in Myrica rubra
Authors: Xu Weijie , Ren Haiying , Qi Xingjiang , Zhang Shuwen , Yu Zheping , Xie Jianbo 
Published: April 2023

Stress response in plant is regulated by a large number of genes co-operating in diverse networks that serve multiple adaptive process. To understand how gene regulatory networks (GRNs) modulating abiotic stress responses, we compare the GRNs underlying drought and cold stresses using samples collected at 4 or 6 h intervals within 48 h in Chinese bayberry (Myrica rubra). We detected 7,583 and 8,840 differentially expressed genes (DEGs) under drought and cold stress respectively, which might be responsive to environmental stresses. Drought- and cold-responsive GRNs, which have been built according to the timing of transcription under both abiotic stresses, have a conserved trans-regulator and a common regulatory network. In both GRNs, basic helix-loop-helix family transcription factor (bHLH) serve as central nodes.MrbHLHp10transcripts exhibited continuous increase in the two abiotic stresses and acts upstream regulator ofASCORBATE PEROXIDASE(APX) gene. To examine the potential biological functions ofMrbHLH10, we generated a transgenicArabidopsisplant that constitutively overexpresses theMrbHLH10gene. Compared to wild-type (WT) plants, overexpressing transgenicArabidopsisplants maintained higher APX activity and biomass accumulation under drought and cold stress. Consistently, RNAi plants had elevated susceptibility to both stresses. Taken together, these results suggested thatMrbHLH10mitigates abiotic stresses through the modulation of ROS scavenging.
OsMYB7 determines leaf angle at the late developmental stage of lamina joints in rice
Authors: Kim Suk-Hwan , Yoon Jungwon , Kim Hanna , Lee Sang-Ji , Kim Taehoon , Kang Kiyoon , Paek Nam-Chon 
Published: April 2023

Leaf angle shapes plant architecture, allowing for optimal light interception to maximize photosynthesis and yield, and therefore is a crucial agronomic trait. Here, we show that the rice (Oryza sativa L.) R2R3-type MYB transcription factor OsMYB7 determines leaf angle in a developmental stage-specific manner. OsMYB7-overexpressing lines produced wide-angled leaves and osmyb7 knockout mutants exhibited erect leaves. This phenotype was restricted to the lamina joints at the late developmental stage. In agreement with these observations, OsMYB7 was preferentially expressed in the lamina joints of post-mature leaves. Since OsMYB7 homologs are transcriptional repressors of lignin biosynthesis, we examined whether OsMYB7 might inhibit thickening of secondary cell walls. Although OsMYB7 repressed lignin biosynthesis, it enhanced thickening of sclerenchyma cell walls by elevating cellulose contents at the lamina joints. Furthermore, we found that OsMYB7 affects endogenous auxin levels in lamina joints, and the adaxial cells of lamina joints in OsMYB7-overexpressing lines and osmyb7 knockout mutants exhibited enhanced and reduced elongation, respectively, compared to the wild type. These results suggest that OsMYB7 promotes leaf inclination partially through decreasing free auxin levels and promoting cell elongation at the adaxial side of lamina joints.
Exploring the long-term sequelae of childhood sexual abuse on risky sexual behavior among Chinese transgender women
Authors: Chen Yingjie , Chang Ruijie , Hu Fan , Xu Chen , Yu Xiaoyue , Liu Shangbin , Xia Danni , Chen Hui , Wang Rongxi , Liu Yujie , Ge Xin , Ma Tiecheng , Wang Ying , Cai Yong 
Published: April 2023

IntroductionChildhood sexual abuse (CSA) is a hidden but serious public health issue that can lead to a series of behavioral consequences and health problems in adulthood. It has been well documented that transgender women (TGW) have a high prevalence of CSA victimization. Moreover, risky sexual behaviors are also widespread among TGW; nevertheless, research investigating the associations between CSA victimization and risky sexual behaviors in TGW represents a gap in the literature.MethodsOur research was carried out mainly in Shenyang of China from November 2018 to January 2019. Sociodemographic characteristics, as well as information on participants’ HIV awareness and sexual behaviors, were collected through face-to-face interviews. The impact of CSA was examined through hierarchical logistic regression, adjusted for sociodemographic factors and HIV awareness.ResultsIn the sample of 247 adult TGW, 14.2% of them had a CSA history. In the previous 6 months, 30.8% of the participants reported condomless anal intercourse (CAI) and 38.5% of them had multiple sexual partners (MSP). The findings demonstrated that TGW with CSA history were more likely to take part in CAI (p = 0.001, OR = 4.252) or have MSP (p = 0.004, OR = 3.260) in adulthood. Furthermore, HIV knowledge was not a predictor of CAI or MSP, but higher HIV risk perception was associated with a greater probability of CAI.ConclusionTransgender women with a history of CSA were more prone to engage in CAI and have MSP in China.
Exposure, perceived risk, and psychological distress among general population during the COVID-19 lockdown in Wuhan, China
Authors: Liu Yujun , Liu Linping , Shi Zhilei 
Published: April 2023

IntroductionThe COVID-19 pandemic that has been going on since the end of 2019 impacts people on both the physical and psychological levels. However, the psychological status, especially its underlying psychosocial mechanisms among the general population in Wuhan, the earliest epicenter and hardest-hit city in China during the pandemic, has not been well investigated. This study aimed to examine the relationships between exposures, perceived risk, and psychological distress among the general population in Wuhan during the COVID-19 lockdown.MethodsData were from a cross-sectional online survey conducted from 20 February to 4 March 2020. Final analyses included 4,234 Wuhan respondents. A 5-item Hopkins Symptom Checklist was adopted to assess respondents’ psychological distress.ResultsIt was found that nervousness, fear, and worry were the most common symptoms among Wuhan residents during the lockdown. Exposure within a close physical distance, exposure within the social network, and perceived risk are significantly positively related to respondents’ psychological distress. Moreover, perceived risk mediated the effects of exposures on respondents’ psychological condition.DiscussionThese findings conduce to identify the populations at higher risk of suffering psychological disturbance during the pandemic and are expected to inform the policymakers and mental health professionals to monitor and improve the perception of risk among the target population by appropriate interventions.
Personality traits as mediators in the association between SIRT1 rs12415800 polymorphism and depressive symptoms among Chinese college students
Authors: Wang Chenliu , Ji Lei , Ren Decheng , Yuan Fan , Liu Liangjie , Bi Yan , Guo Zhenming , Yang Fengping , Xu Yifeng , Yu Shunying , Yi Zhenghui , He Lin , Liu Chuanxin , He Guang , Yu Tao 
Published: April 2023

BackgroundPrevious research has linked polymorphisms in the SIRT1 gene to depressive symptoms, particularly in Chinese individuals. However, it is not clear how personality traits may contribute to this association.MethodsTo explore the potential mediating effect of personality traits, we utilized a mediation model to examine the relationship between the SIRT1 rs12415800 polymorphism and depressive symptoms in 787 Chinese college students. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale, while personality traits were measured using the Big Five Inventory (BFI).ResultsOur analysis indicated a significant association between the SIRT1 rs12415800 polymorphism and depressive symptoms, with this relationship partially mediated by the personality traits of neuroticism and conscientiousness. Specifically, individuals who were heterozygous for the rs12415800 polymorphism and had higher levels of conscientiousness were less likely to experience depressive symptoms. Conversely, those who were homozygous for the rs12415800 polymorphism and had higher levels of neuroticism were more likely to experience depressive symptoms.ConclusionOur results suggest that personality traits, particularly neuroticism and conscientiousness, may play a critical role in the association between the SIRT1 rs12415800 polymorphism and depressive symptoms among Chinese college students. These findings highlight the importance of considering both genetic factors and personality traits when exploring the etiology of depressive symptoms in this population.
Association of social capital with self-perceived eHealth literacy among community-dwelling older people: Age and gender differences
Authors: Cao Chenglin , Cao Wenwen , Zheng Xin , Ji Kai , Wu Yunwei , Hu Zhi , Chen Ruoling , Bai Zhongliang 
Published: April 2023

BackgroundStudies have confirmed that social factors, including social capital and eHealth literacy, are important in later life. Currently, few studies are available for determining the relationship between social capital and eHealth literacy, and whether such a relationship exists among older people and there are age and gender differences in the relationship remain unclear. Consequently, this study aimed to investigate the association between social capital and eHealth literacy, specifically examing its variations in age and gender.MethodsA cross-sectional study of 4,257 residents aged ≥ 60 years and dwelling in the community was conducted across four cities in China. A structured questionnaire was used to collect data on general characteristics, socioeconomic status, social capital, and eHealth literacy. Generalized linear models were employed to assess these associations.ResultsThere were 4,218 respondents (age 71.9 ± 7.2 years; 64.8% women). Overall, social participation, social connection, trust, cohesion, and reciprocity were all statistically associated with eHealth literacy (p &lt; 0.05), while such an association was not observed for social support (p &gt; 0.05). Specifically, a higher level of social participation was associated with better eHealth literacy scores among participants aged 70–79 years (p &lt; 0.001), and a higher level of social connection was associated with better eHealth literacy scores for those aged 60–69 and 70–79 years (p &lt; 0.001). Meanwhile, no gender differences in the associations were found.ConclusionThere is an association between social capital and eHealth literacy in older men and women. The association varis with age. The findings provide a reference for developing targeted measures to improve self-perceived eHealth literacy among older people. It is essential for achieving active and healthy aging and developing the knowledge and understanding of relevant theories, concepts, and evidence within the field of health and social capital.
The associations between working conditions and subjective sleep quality among female migrant care workers
Authors: Chen I-Ming , Lin Tzu-Yun , Chien Yi-Ling , Chen Jennifer Yi-Ying , Chan Jen-Hui , Liao Shih-Cheng , Kuo Po-Hsiu , Chen Hsi-Chung 
Published: April 2023

BackgroundSubjective sleep quality may reflect the mental well-being of migrant care workers; however, the related occupational factors remain unclear. This study examines the association between the characteristics of care labor and the subjective sleep quality of female migrants.MethodsIn this cross-sectional study, Southeast Asian migrant care workers in Taiwan were recruited using convenience sampling. Data on working conditions, including workplace setting, wage, working hours, psychiatric symptoms of care recipients, and sleep quality measured using the Pittsburgh Sleep Quality Index (PSQI), were collected through computer-assisted personal interviews. Multiple linear regression analyses were performed to determine the independent relationship between working conditions and the PSQI global score.ResultsThere were 220 institution-(47.7%) and home-based (52.3%) care workers, and 47.7% had a PSQI score higher than 5. After controlling for covariates, the lowest tertile of wages and daily working hours (&gt; 8 h) were independently correlated with poor sleep quality. Moreover, in the stepwise regression model, wage and working hours remained the most explainable correlates of poor sleep quality.ConclusionThis study lent support to the notion that low wages and long working hours are significant occupational factors that negatively impact the subjective sleep quality of female Southeast Asian migrant care workers in Taiwan.
Gender differences in family meal frequency and their association with substance use and mental health among middle and high school students
Authors: Luo Ting , Cummins Sharon E. , Zhu Shu-Hong 
Published: April 2023

BackgroundFamily meals are associated with adolescent health outcomes. Studies have reported that girls are less likely than boys to have dinner with their families.PurposeThis study examined gender differences in family meal frequency and the relationship between meal frequency and other health measures, using a large and representative sample of California middle and high school students.MethodsThis study analyzed data from the 2019–2020 California Student Tobacco Survey (159,904 students in grades 8, 10, and 12). Dinner with the family 5–7 times per week was defined as high frequency. Students reported substance use (of tobacco, marijuana, and alcohol) and rated their mental health and happiness in their home life. All analyses were weighted to reflect the California student population.ResultsFewer than half (44.7%) of students reported a high frequency of family meals, with boys more likely than girls and those who identified their gender in another way the least likely to do so (48.3%, 42.2%, 34.0%, respectively). Gender differences persisted across demographics and the quality of family relationships, and were evident as early as eighth grade. Less frequent family meals were associated with poorer mental health (OR = 1.34, 95% CI: 1.29–1.40) and substance use (OR = 1.27, 95% CI: 1.21–1.32), controlling for the effects of demographics and family dynamics.ConclusionGender differences in family meal frequency emerge early in adolescence and persist across demographics and family relationships. Given that family meals play a protective role in an adolescent’s life, these gender differences are concerning.
Fatigue as a key human factor in complex sociotechnical systems: Vessel Traffic Services
Authors: Crestelo Moreno Fernando , Soto-López Verónica , Menéndez-Teleña Deva , Roca-González Joaquín , Suardíaz Muro Juan , Roces Cristina , Paíno Mercedes , Fernández Imma , Díaz-Secades Luis Alfonso 
Published: April 2023

BackgroundVessel Traffic Services (VTS) are considered a subsystem of people, whose mission is to improve the effectiveness and efficiency of maritime transport within the maritime system. VTS operate as a control system where Vessel Traffic Services Operators (VTSOs) must cope with a complex environment to make up for safe and efficient maritime transport, so it is essential to understand how these operators maintain control through adapting to the uncertain and dynamic environment of maritime traffic. This multidisciplinary study explores how human factors within this complex sociotechnical system, means VTS, play a role in maritime safety, specifically focusing on fatigue, which is considered a key variable for VTSOs’ performance. In this context, the research has focused on the assessment of fatigue with psychological and operational instruments to highlight the importance of the human element in CSSs.ObjectiveTo study the intra and inter-individual differences in fatigue ratings and their relationships with other personal and environmental variables: mental workload, work shifts, reaction time, and hours of usual sleep.MethodsThe study was conducted in two of the 19 Spanish Maritime Rescue Coordination Centers (MRCCs) with a sample of 23 active VTSOs (82.14% of the staff). Both objective and standardized subjective measures were used to assess fatigue and associated sleepiness (Borg RPE, Nasa-TLX, Stanford Sleepiness Scale, and Self-Assessment Manikin Scale).ResultsA significant positive correlation between fatigue and mental workload was found, being more prevalent in the night shift, which shows a bigger variation in these variables. A significant difference was found in the increase in fatigue experienced throughout the shift depending on the hours of usual sleep, being smaller in the group of subjects reporting to sleep more.ConclusionThe human element is key to maritime safety related to Vessel Traffic Services, so it is of paramount importance to consider certain measures to counteract the negative effects of fatigue. A proper organization of duties on/off periods, assessment of work and rest schedules, and the implementation of fatigue management programs based on sleep education are recommended.
Shelf-life extension of traditional licorice root “sherbet” with a novel pulsed electric field processing
Authors: Akdemir Evrendilek Gulsun , Tanriverdi Hakan , Demir Irem , Uzuner Sibel 
Published: April 2023

Pulsed electric field (PEF) processing of licorice root “sherbet” (LRS) by various electric field strengths (7.00, 15.50, and 24.10 kV/cm), treatment times (108, 432, and 756 µsec), and processing temperatures (6, 18, and 30°C) according to the Box–Behnken design were performed. The samples were analyzed for pH, titratable acidity, conductivity, turbidity, total reducing sugar, color (L*, a*, and b*), hue, chroma, total color difference, color intensity, color tone (yellow, red, and blue color tones), total antioxidant capacity, total phenolic substance content, and sensory properties. Results revealed that PEF processing did not adversely affect most of the physical, chemical, and sensory properties of LRS, with a maximum of 2.48, 4.04, 1.78, and 1.20 log reductions on the initial total mesophilic aerobic bacteria, total mold and yeast, Bacillus circulans, and Candida tropicalis. The response variable modeled for the PEF was found to be conductivity, with the optimum processing conditions of 6.90 kV/cm, 756.00 µs, and 7.48°C. After that, the samples were stored at 4°C and 22°C for shelf-life studies. Control samples at 4°C and 22°C were spoiled on the fifth and second days, whereas PEF-treated samples stored at 4°C began to deteriorate after the 40th day and the samples stored at 22°C after the 30th day, respectively. It was revealed that PEF is a suitable process to extend the shelf-life of licorice “sherbet” with preservation of physicochemical and sensory properties.