bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic floor hypertension: possible factors for pelvic floor tenderness in endometriosis patients—a pilot study
Authors: Muallem Jumana , Velho Renata Voltolini , Netzl Johanna , Sehouli Jalid , Mechsner Sylvia 
Published: September 2023

Abstract
Purpose
Chronic pelvic pain (CPP) is one of the main problems of endometriosis, leading to a significant impairment of quality of life. Understanding the pain mechanisms and the pelvic floor muscles (PFM) changes in these patients is essential to integrate additional therapeutic strategies. We hypothesize that endometriosis patients have changes in PFM and that targeted vaginal electrostimulation can be a treatment option for CPP in this disease.

Methods
Fifteen patients with endometriosis and chronic acyclical pelvic pain were included. PFM electromyography with the Multiple Array Probe Leiden (MAPLe) was performed. Mapping of PFM was utilized and targeted electrostimulation of the hypertensive muscles was conducted. Control electromyography was performed afterward to evaluate the electrostimulation therapeutic effect.

Results
In 12/15 (80%) patients, the myofascial trigger point could be localized by digital examination. The most frequently affected muscle was the puborectalis (10/15—66.7%). Most of the patients showed serious changes in the average resting tone (aRT) of PFM. aRT was significantly increased in all patients and decreased after stimulation, whereby the difference prior to and after stimulation was not significant (p = 0.064). The detailed separated analysis of the hypertensive muscles showed a significant (p = 0.026) reduction in their resting tone (hRT), after targeted stimulation.

Conclusion
Vaginal electrostimulation is a promising and feasible complementary treatment option for CPP in endometriosis patients. Targeted treatment of pelvic floor dysfunction should be included in clinical trials.
Accelerated corneal cross-linking (18mW/cm2 for 5 min) with HPMC-riboflavin in progressive keratoconus – 5 years follow-up
Authors: Friedrich Julia , Sandner Alexandra , Nasseri Ali , Maier Mathias , Zapp Daniel 
Published: September 2023

Abstract
Purpose
To evaluate long-term results of accelerated corneal cross-linking (ACXL) in patients with progressive keratoconus, seventy-four eyes of 53 patients with progressive keratoconus (documented Kmax progression > 1D/a) who underwent ACXL (18mW/cm2 for 5 min) were included in a retrospective observational clinical study. The investigation focused on tomographic and keratometric parameters, refractive data, and visual outcomes at 5 years follow-ups.

Methods
Corrected distance visual acuity (CDVA), slit lamp, and Pentacam® examinations were conducted, including assessments of thinnest corneal point (TP), minimum radius (Rmin), corneal astigmatism, and maximum anterior keratometry (Kmax). These examinations were performed two weeks before the surgery and, on average, 56 months after the surgery. In a subgroup of 24 eyes, Pentacam® examination data from an intermediate visit at 12 months until the final visit was evaluated to confirm continuous stability.
The ACXL protocol included corneal abrasion, hydroxypropylmethylcellulose (HPMC)-riboflavin eye drops administered every 5 min for a total duration of 30 min, and irradiation with 18mW/cm2 for 5 min using riboflavin eye drops applied every minute during the irradiation process. Intraoperatively, minimal corneal pachymetry of > 400 µm was ensured in every patient.

Results
After 56 months, all values exhibited statistically significant changes (paired t-test; CDVA p = 0.002; Kmax p < 0.001; Rmin p < 0.001; astigmatism p = 0.03; TP p < 0.001).
In the subgroup analysis of 24 eyes, which included tomographical and keratometric parameters, no statistically significant changes were observed during the last 12 months of observation (paired t-test; Kmax p = 0.72; Rmin p = 0.67; astigmatism p = 0.72).
Treatment failure was strictly defined as an increase in Kmax (> 1D) during the 5-year follow-up and was observed in only 3 eyes (4%).

Conclusions
ACXL is an effective and safe treatment for patients with progressive keratoconus. Our results demonstrate improvements in functional and tomographical outcomes even after high-energy ACXL (18mW/cm2 for 5 min) over a long-term period of 56 months. Our analysis indicates stable conditions in previously progressive keratoconus, particularly during the final year of the observation period. The treatment failure rate was 4%.
Afferent neurons of the kidney with impaired firing pattern in inflammation – role of sodium currents?
Authors: Lale Nena , Ditting Tilmann , Hilgers Karl F. , Linz Peter , Ott Christian , Schmieder Roland E. , Schiffer Mario , Amann Kerstin , Veelken Roland , Rodionova Kristina 
Published: September 2023

AbstractPeripheral neurons with renal afferents exhibit a predominantly tonic firing pattern of higher frequency that is reduced to low frequencies (phasic firing pattern) in renal inflammation. We wanted to test the hypothesis that the reduction in firing activity during inflammation is due to high-activity tonic neurons switching from higher to low frequencies depending on altered sodium currents. We identified and cultivated afferent sensory neurons with renal projections from the dorsal root ganglia (Th11-L2). Cultivated neurons were incubated with the chemokine CXCL1 (1,5 nmol/ml) for 12 h. We characterized neurons as “tonic,” i.e., sustained action potential (AP) firing, or “phasic,” i.e., < 5 APs upon stimulation in the current clamp. Their membrane currents were investigated in a voltage clamp. Data analyzed: renal vs. non-renal and tonic vs. phasic neurons. Renal afferent neurons exposed to CXCL1 showed a decrease in tonic firing pattern (CXCL1: 35,6% vs. control: 57%, P < 0.05). Na+ and K+ currents were not different between control renal and non-renal DRG neurons. Phasic neurons exhibited higher Na+ and K+ currents than tonic resulting in shorter APs (3.7 ± 0.3 vs. 6.1 ± 0.6 ms, P < 0.01). In neurons incubated with CXCL1, Na+ and K+ peak current density increased in phasic (Na+: − 969 ± 47 vs. − 758 ± 47 nA/pF, P < 0.01; K+: 707 ± 22 vs. 558 ± 31 nA/pF, P < 0.01), but were unchanged in tonic neurons. Phasic neurons exposed to CXCL1 showed a broader range of Na+ currents ([− 365– − 1429 nA] vs. [− 412– − 4273 nA]; P < 0.05) similar to tonic neurons. After CXCL1 exposure, significant changes in phasic neurons were observed in sodium activation/inactivation as well as a wider distribution of Na+ currents characteristic of tonic neurons. These findings indicate a subgroup of tonic neurons besides mere tonic or phasic neurons exists able to exhibit a phasic activity pattern under pathological conditions.
Correlation between anthropometric measurements and graft size in anterior cruciate ligament reconstruction: a systematic review and meta-analysis
Authors: Salman Loay A. , Moghamis Isam Sami , Hatnouly Ashraf T. , Khatkar Harman , Alebbini Mohanad Mutasem , Al-Ani Abdallah , Hameed Shamsi , AlAteeq Aldosari Mohamed 
Published: September 2023

Abstract
Purpose
This systematic review and meta-analysis aimed to investigate the correlation between anthropometric measurements and graft size in anterior cruciate ligament (ACL) reconstruction.

Methods
A systematic search of Ovid MEDLINE, Embase, and Cochrane Library databases was conducted for observational studies published until March 2023 that reported the relationship between anthropometric data [height, weight, body mass index (BMI), age, gender, thigh length, and circumference] and ACL graft size. Correlation coefficients (COR) and their associated 95% confidence intervals were used as the primary effect size. This review was conducted in line with PRISMA guidelines.

Results
A total of 42 observational studies involving 7110 patients were included, with a mean age of 29.8 years. Statistically significant, moderately positive correlations were found between graft size and height (COR: 0.49; 95% CI: 0.41–0.57; p-value: < 0.001), weight (COR: 0.38; 95% CI: 0.31–0.44; p-value: < 0.001), thigh circumference (COR: 0.40; 95% CI: 0.19–0.58; p-value: < 0.001), and thigh length (COR: 0.35; 95% CI: 0.18–0.50; p-value: < 0.001). However, age and gender were insignificantly correlated with graft size (p-value: NS). A subanalysis based on graft type showed a significant positive correlation between height and graft diameter, which was more significant in the peroneus tendon than in hamstring grafts (COR: 0.76 vs. 0.45; p-value: 0.020).

Conclusion
This study demonstrated a moderate positive correlation between anthropometric measurements (height, weight, thigh circumference, and length) and ACL graft size, along with a weak positive correlation with BMI. Age and gender showed no significant correlation. These findings support the predictability and selection of ACL graft size based on pre-operative patient anthropometric data.

Level of evidence
Level of Evidence: IV.
PROSPERO registration number: CRD42023416044.
Synergistic effects of low - level magnesium and chromium doping on the electrochemical performance of LiNiO2 cathodes
Authors: Laine Petteri , Välikangas Juho , Kauppinen Toni , Hu Tao , Wang Shubo , King Graham , Singh Harishchandra , Tynjälä Pekka , Lassi Ulla 
Published: September 2023

AbstractLiNiO2 cathode materials with magnesium and chromium doping were prepared using a simple low - cost and efficient co - precipitation and lithiation procedure. During this procedure, both magnesium and chromium form a concentrated core particle, unto which nickel hydroxide precipitates. During lithiation, the elements in question will redistribute themselves and form a homogenous mixture. Magnesium - containing materials exhibit an excellent electrochemical performance, due to phase stabilizing effects, while for chromium - containing materials, performance remains poor. Rietveld refinement reveals that there is a possible upper limit for Mg doping (~ 2.5 mol %) as a pilar dopant. Washing of the lithiated materials was explored, and it is proposed that this can improve capacity retention in prolonged cycling. However, the inevitable loss of lithium from the surface layer remains a challenge. Two sources for the chromium facilitated capacity decay are proposed, both owing to the highly irreversible redox reaction of hexavalent chromium possibly blocking lithium pathways.
Tumor size, treatment patterns, and survival in neuro-oncology patients before and during the COVID-19 pandemic
Authors: Karamani Lydia , McLean Aaron Lawson , Kamp Marcel A. , Mayer Thomas E. , Müller Wolf , Dinc Nazife , Senft Christian 
Published: September 2023

AbstractThe COVID-19 pandemic has disrupted healthcare delivery worldwide, leading to significant delays in cancer diagnosis and treatment. This study aimed to investigate the impact of the pandemic on the diagnosis and treatment of malignant brain tumors, specifically glioblastoma (GBM) and cerebral metastasis (CM), in a specialized neuro-oncology center. We analyzed data from 236 patients diagnosed with previously unknown malignant brain tumors between January 2018 and December 2021. Patients were classified into two groups: pre-COVID (January 2018 to December 2019) and COVID (January 2020 to December 2021). Tumor volumes were compared between the two groups and factors affecting tumor volumes were studied. Of 236 patients diagnosed with previously unknown malignant brain tumors, 114 were in the pre-COVID group and 122 were in the COVID group. Median tumor volumes at first diagnosis were significantly larger in the COVID group compared to the pre-COVID group (21.7 vs 15.7 cm3; p < 0.05). The survival times for the overall cohort and the GBM and CM subgroups did not differ significantly between the pre-COVID and COVID periods. Delays in diagnosis and treatment during the COVID-19 pandemic led to larger tumor volumes at diagnosis for patients with malignant brain tumors. However, these larger tumors did not result in worse survival outcomes. This counterintuitive finding highlights the crucial role of specialized neuro-oncological centers in mitigating the potential negative impact of delayed treatment and emphasizes the need for continued access to specialized care during times of crisis.
Global Connections and Connected Communities in the African Past: Stories from Cowrie Shells
Authors: Haour Anne , Moffett Abigail 
Published: September 2023

AbstractThrough the stories of four people who carried or traded cowrie shells, this article examines the connections between various parts of the world from a thousand years ago to the present. These connections spanned great distances, linking communities in West Africa and the Indian Ocean islands of the Maldives, and they bring to light the vast land and sea links that connected different regions of the African continent to the wider world in this period. We use cowrie shells to explore how objects participate in creating social relations, shaping senses of self and identity. When viewed in relation to the theme of connections, this offers a springboard for thinking about how things and their biographies fit within our lives today.
Accumulation and within-mushroom distribution of elements in red cracking bolete (Xerocomellus chrysenteron) collected over the extended period from compositionally contrasting substrates
Authors: Andronikov Alexandre V. , Andronikova Irina E. , Sebek Ondrej , Martinkova Eva , Stepanova Marketa 
Published: September 2023

AbstractWe conducted a study of elemental compositions of Xerocomellus chrysenteron samples accompanied by samples of related substrate soils. All samples were collected during the harvesting seasons 2021 and 2022 from three forested sites almost unpolluted by recent human activities and underlain by contrasting bedrock (granite, amphibolite, and serpentinite). Elements such as Ag, Cd, K, P, Rb, S, Se, and Zn were the main elements enriched in the mushroom’s fruiting bodies relative to the substrate. Concentrations of most elements in mushrooms were not site-dependent, with only Ag, As, Rb, and Se concentrations significantly depending on the bedrock composition. Some elements analyzed in mushrooms displayed temporal features, but such features were not systematic and varied for each element. Most analyzed elements were distributed unevenly within the mushroom’s fruiting bodies, with apical parts generally enriched in mobile elements. Mushrooms influenced concentrations of Ag, Cd, K, and Rb and a few other elements in the substrate via uptake, but such influence was very limited and can be responsible for only 2.5–11.5% of total depletion of the affected substrate in the named elements.
Dense subgraphs induced by edge labels
Authors: Kumpulainen Iiro , Tatti Nikolaj 
Published: September 2023

AbstractFinding densely connected groups of nodes in networks is a widely-used tool for analysis in graph mining. A popular choice for finding such groups is to find subgraphs with a high average degree. While useful, interpreting such subgraphs may be difficult. On the other hand, many real-world networks have additional information, and we are specifically interested in networks with labels on edges. In this paper, we study finding sets of labels that induce dense subgraphs. We consider two notions of density: average degree and the number of edges minus the number of nodes weighted by a parameter $$\alpha$$
α
. There are many ways to induce a subgraph from a set of labels, and we study two cases: First, we study conjunctive-induced dense subgraphs, where the subgraph edges need to have all labels. Secondly, we study disjunctive-induced dense subgraphs, where the subgraph edges need to have at least one label. We show that both problems are NP-hard. Because of the hardness, we resort to greedy heuristics. We show that we can implement the greedy search efficiently: the respective running times for finding conjunctive-induced and disjunctive-induced dense subgraphs are in $$\mathcal {O} \mathopen {}\left( p \log k\right)$$

O

p
log
k

and $$\mathcal {O} \mathopen {}\left( p \log ^2 k\right)$$

O

p

log
2

k

, where p is the number of edge-label pairs and k is the number of labels. Our experimental evaluation demonstrates that we can find the ground truth in synthetic graphs and that we can find interpretable subgraphs from real-world networks.
Efficient generator of mathematical expressions for symbolic regression
Authors: Mežnar Sebastian , Džeroski Sašo , Todorovski Ljupčo 
Published: September 2023

AbstractWe propose an approach to symbolic regression based on a novel variational autoencoder for generating hierarchical structures, HVAE. It combines simple atomic units with shared weights to recursively encode and decode the individual nodes in the hierarchy. Encoding is performed bottom-up and decoding top-down. We empirically show that HVAE can be trained efficiently with small corpora of mathematical expressions and can accurately encode expressions into a smooth low-dimensional latent space. The latter can be efficiently explored with various optimization methods to address the task of symbolic regression. Indeed, random search through the latent space of HVAE performs better than random search through expressions generated by manually crafted probabilistic grammars for mathematical expressions. Finally, EDHiE system for symbolic regression, which applies an evolutionary algorithm to the latent space of HVAE, reconstructs equations from a standard symbolic regression benchmark better than a state-of-the-art system based on a similar combination of deep learning and evolutionary algorithms.
Non-invasive phenotyping for water and nitrogen uptake by deep roots explored using machine learning
Authors: Changdar Satyasaran , Popovic Olga , Wacker Tomke Susanne , Markussen Bo , Dam Erik Bjørnager , Thorup-Kristensen Kristian 
Published: September 2023

Abstract
Background and aims
Root distribution over the soil profile is important for crop resource uptake. Using machine learning (ML), this study investigated whether measured square root of planar root length density (Sqrt_pRLD) at different soil depths were related to uptake of isotope tracer (15N) and drought stress indicator (13C) in wheat, to reveal root function.

Methods
In the RadiMax semi-field root-screening facility 95 winter wheat genotypes were phenotyped for root growth in 2018 and 120 genotypes in 2019. Using the minirhizotron technique, root images were acquired across a depth range from 80 to 250 cm in May, June, and July and RL was extracted using a convolutional neural network. We developed ML models to explore whether the Sqrt_pRLD estimates at different soil depths were predictive of the uptake of deep soil nitrogen - using deep placement of 15N tracer as well as natural abundance of 13C isotope. We analyzed the correlations to tracer levels to both a parametrized root depth estimation and an ML approach. We further analyzed the genotypic effects on root function using mediation analysis.

Results
Both parametrized and ML models demonstrated clear correlations between Sqrt_pRLD distribution and resource uptake. Further, both models demonstrated that deep roots at approx. 150 to 170 cm depth were most important for explaining the plant content of 15N and 13C isotopes. The correlations were higher in 2018.

Conclusions
The results demonstrated that, parametrized models and ML-based analysis provided complementary insight into the importance of deep rooting for water and nitrogen uptake.
Exploring and Measuring Quality of Life Determinants of Wage Workers in Egypt: A Structural Equation Modelling Approach
Authors: Zeini Nahed T. , Okasha Ahmed E. , Soliman Amal S. 
Published: September 2023

AbstractThis paper aims to identify the major significant dimensions that contribute to the overall quality of life (QOL) of wage workers in Egypt. As the QOL is a complex, multidimensional, and interdisciplinary concept, forty-seven indicators under five domains were chosen to investigate the QOL determinants of wage workers in Egypt, namely job characteristics, job satisfaction, ICT access, gender equality and women empowerment, and neighborhood services and utilities. Using data from the 2018 wave of the Egypt Labor Market Panel Survey, the paper employed structural equation modelling (SEM) approach to investigate the impact of proposed dimensions on the overall QOL. In addition, multi-group SEM analysis was implemented to measure how people differ in the way they assess their QOL on the basis of various moderating variables such as the geographical region of residence, age group, and years of schooling. The findings showed the significant impact of the chosen dimensions on the overall QOL. Moreover, the multi-group models showed a significant variation among compared groups, in which the weights of dimensions vary due to the differences in socio-cultural characteristics and the surrounding environment, confirming the complexity of such a concept. As people usually differ in the way they assess their QOL, which is affected by their characteristics and priorities.
Does Renal Denervation a Reasonable Treatment Option in Hemodialysis-Dependent Patient with Resistant Hypertension? A Narrative Review
Authors: Mazza Alberto , Dell’Avvocata Fabio , Torin Gioia , Bulighin Francesca , Battaglia Yuri , Fiorini Fulvio 
Published: September 2023

Abstract
Purpose of Review
This narrative review aims to assess the pathophysiology, diagnosis, and treatment of resistant hypertension (RH) in end-stage kidney disease (ESKD) patients on dialysis, with a specific focus on the effect of renal denervation (RDN) on short-term and long-term blood pressure (BP) control. Additionally, we share our experience with the use of RDN in an amyloidotic patient undergoing hemodialysis with RH.

Recent Findings
High BP, an important modifiable cardiovascular risk factor, is often observed in patients in ESKD, despite the administration of multiple antihypertensive medications. However, in clinical practice, it remains challenging to identify RH patients on dialysis treatment because of the absence of specific definition for RH in this context. Moreover, the use of invasive approaches, such as RDN, to treat RH is limited by the exclusion of patients with reduced renal function (eGFR < 45 mL/min/1.73 m3) in the clinical trials. Nevertheless, recent studies have reported encouraging results regarding the effectiveness of RDN in stage 3 and 4 chronic kidney disease (CKD) and ESKD patients on dialysis, with reductions in BP of nearly up to 10 mmhg.

Summary
Although multiple underlying pathophysiological mechanisms contribute to RH, the overactivation of the sympathetic nervous system in ESKD patients on dialysis plays a crucial role. The diagnosis of RH requires both confirmation of adherence to antihypertensive therapy and the presence of uncontrolled BP values by ambulatory BP monitoring or home BP monitoring. Treatment involves a combination of nonpharmacological approaches (such as dry weight reduction, sodium restriction, dialysate sodium concentration reduction, and exercise) and pharmacological treatments. A promising approach for managing of RH is based on catheter-based RDN, through radiofrequency, ultrasound, or alcohol infusion, directly targeting on sympathetic overactivity.