bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Deskripsi Pekerjaan, Disiplin Dan Etika Kerja Terhadap Prestasi Kerja Aparatur Sipil Negara (Asn) Pada Kantor Sekretariat Dprd Provinsi Sumatera Utara
Authors: Dewi Sri Puspa , Sinto Sinto , Husna Asmaul 
Published: June 2023

This research was conducted at the secretariat of the DPRD of North Sumatra Province, where the purpose of this study was to determine the extent to which job description, discipline and work ethics, both partially and simultaneously affect the work performance of employees within the secretariat of the DPRD of North Sumatra Province. This study used quantitative methods, where the population in this study was 46 employees, and the sample taken was as much as 100% of the total population because the number was not up to 100 people. The results of this research show that partially the job description variable (X1) and work ethic variable (X3) have a significant effect on employee work performance within the secretariat of the DPRD of North Sumatra Province (Y), with a t calculate value of 2.194 and a significance level value of 0.003 smaller than 0.05 partially the job description (X1) has a significant effect on the work performance of employees within the secretariat of the DPRD of North Sumatra Province (Y), and a t calculated value of 3.835 and a significant level of 0.000 smaller than 0.05 partially work ethics (X3) has a significant effect on the work performance of employees within the secretariat of the DPRD of North Sumatra Province (Y). Meanwhile, simultaneously, both job description (X1), discipline (X2) and work ethics (X3) have a significant effect on the work performance of employees within the secretariat of the DPRD of North Sumatra Province, with a F calculated value of 7,351 and a significant level value of 0.000 less than 0.05
STRUCTURAL SYNTHESIS OF CLOSED KINEMATIC CHAINS OF MOVING LINKS OF THE FIFTH, SIXTH, SEVENTH AND THE EIGHTH SUBFAMILY OF THE FIRST FAMILY
Authors: Vovkotrub Valeriy 
Published: June 2023

The study objective is to develop a method of structural synthesis of closed kinematic chains of moving links into the fifth, sixth, seventh and eighth subfamilies of the first family.
Tasks: to obtain a complete set of solutions describing the arrangement of closed kinematic chains of moving links of the fifth, sixth, seventh and eighth subfamilies of the first family with the complexity of the basic chain link equal to two and three, the mobility of the chain equaling to six and the total number of chain links from 3 to 6 based on the universal structural system of Professor L.T. Dvornikov for closed kinematic chains of moving links of the first family. Using the data obtained, consider the construction of a block diagram of a closed kinematic chain of moving links of the first family on a specific example.
Research methods: a method of structural synthesis of closed kinematic chains of moving links of the first family is used.
The novelty of the work: the peculiarities of applying a universal structural system for determining the composition of closed kinematic chains of moving links of the fifth, sixth, seventh and eighth subfamilies of the first family are considered. An example of using the obtained combinations of kinematic pairs and links for the synthesis of structural schemes of closed kinematic chains of moving links of the first family is shown.
Study results: combinations of kinematic pairs and links are obtained, which make it possible to find structural schemes of closed kinematic chains of moving links of the fifth, sixth, seventh and eighth subfamilies of the first family under given parameters, from which single-moving mechanisms of the first family can be formed by stopping the link.
Analisis Pengaruh Inflasi, Produk Domestik Bruto, Pertumbuhan Penduduk Dan Sertifikat Bank Indonesia Syariah Terhadap Harga Saham (Studi Kasus Perusahaan Properti Dan Real Estate Dalam Indeks Saham Syariah Indonesia Tahun 2016-2020)
Authors: Andriani Mutia , Hamid Abdul , Fakhrizal  
Published: June 2023

Saham sektor properti dan real estate memiliki ciri tersendiri dari sektor lain dalam bursa. Sektor ini menciptakan dan memenuhi kebutuhan masyarakat yakni tempat tinggal ataupun gedung sehingga menjadikan sektor properti dan real setate sebagai sektor yang menjanjikan. Namun pada kenyataannya, kondisi suatu negara ikut mempengaruhi harga saham properti dan real estate terlebih pada tahun 2019 menyebarnya wabah Covid-19 yang melemahkan perekonomian global tak terkecuali di indonesia yang mengakibatkan permintaan dan penawaran saham pada sektor ini hanya gencar di waktu-waktu tertentu saja. Metode yang digunakan dalam penelitian ini adalah pengumpulan data melalui website dan studi kepustakaan. Total sampel yang diuji sebanyak 10 perusahaan properti dan real estate dalam Indeks Saham Syariah Indonesia tahun 2016-2020 dengan metode purposive sampling. Analisis data dalam penelitian ini menggunakan analisis data panel dengan alat bantu eviews 9. Hasil analisis menunjukkan bahwa secara simultan inflasi, produk domestik bruto, pertumbuhan penduduk dan Sertifikat Bank Indonesia Syariah berpengaruh signifikan terhadap harga saham. Kemudian secara parsial didapati hasil bahwa variabel inflasi berpengaruh negatif dan signifikan dengan nilai probabilitas 0.0464, variabel produk domestik bruto berpengaruh positif dan signifikan dengan nilai probabilitas 0.0000, variabel pertumbuhan penduduk berpengaruh negatif dan tidak signifikan dengan nilai probabilitas 0.4237 dan variabel sertifikat bank Indonesia syariah berpengaruh positif dan signifikan dengan nilai probabilitas 0.000 dengan tingkat kepercayaan sebesar 81,22% sedangkan sisanya sebesar 18,78% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
Kata Kunci: Inflasi, Produk Domestik Bruto, Pertumbuhan penduduk, Sertifikat Bank Indonesia Syariah, Harga Saham Properti.
Mechanisms of Rapid Bactericidal and Anti-Biofilm Alpha-Mangostin In Vitro Activity against Staphylococcus aureus
Authors: Deng Xiangbin , Xu Hongbo , Li Duoyun , Chen Jinlian , Yu Zhijian , Deng Qiwen , Li Peiyu , Zheng Jinxin , Zhang Haigang 
Published: June 2023

Abstract
Alpha-mangostin (α-mangostin) was discovered as a potent natural product against Gram-positive bacteria, whereas the underlying molecular mechanisms are still unclear. This study indicated that α-mangostin (at 4 × MIC) rapidly killed Staphylococcus aureus planktonic cells more effectively (at least 2-log10 CFU/ml) than daptomycin, vancomycin and linezolid at 1 and 3 h in the time-killing test. Interestingly, this study also found that a high concentration of α-mangostin (≥4×MIC) significantly reduced established biofilms of S. aureus. There were 58 single nucleotide polymorphisms (SNPs) in α-mangostin nonsensitive S. aureus isolates by whole-genome sequencing, of which 35 SNPs were located on both sides of the sarT gene and 10 SNPs in the sarT gene. A total of 147 proteins with a different abundance were determined by proteomics analysis, of which 91 proteins increased, whereas 56 proteins decreased. The abundance of regulatory proteins SarX and SarZ increased. In contrast, the abundance of SarT and IcaB was significantly reduced (they belonged to SarA family and ica system, associated with the biofilm formation of S. aureus). The abundance of cell membrane proteins VraF and DltC was augmented, but the abundance of cell membrane protein UgtP remarkably decreased. Propidium iodide and DiBaC4(3) staining assay revealed that the fluorescence intensities of DNA and the cell membrane were elevated in the α-mangostin treated S. aureus isolates. In conclusion, this study reveals that α-mangostin was effective against S. aureus planktonic cells by targeting cell membranes. The anti-biofilm effect of α-mangostin may be through inhibiting the function of SarT and IcaB.
Entrepreneurial Leadership, Entrepreneurial Orientation, Organizational Effectiveness and Their Relationships Towards Firm Performance
Authors: Suhendi Rudi , Soebowo Musa  
Published: June 2023

This study is a cross-sectional descriptive & confimatory study that analyzes the Indonesian heavy equipment industry. Therefore, the results only represent the condition of the industry at a certain point in time the research was conducted, unlike longitudinal data. Another implication is that this research cannot determine causality between constructs and can only represent the current condition.
The construct that the author measures is entrepreneurial leadership (EL), entrepreneurial orientation (EO), organizational effectiveness (OE) and Firm performance (FP).
FP is a relevant construct in strategic management research and is often used as the dependent variable. Despite this relevance, there is almost no consensus on its definition, dimensions and measurement, what is limiting progress in research and understanding of the concept.
Successful FP operating in dynamic and changing environments have the ability to reach out and explore new sights. When the current conditions for new employee recruitment have been reduced, even every year there are no additional new employees, expenses, optimization & additional work jobs for each employee, etc. Possibly with this, I as the author would like to examine current in the company whether they have EL, EO, OE to improve FP, where employees understand and apply how Risks of risk and uncertainty as well as being proactive in maintaining the company's growth, so that the company can survive in a dynamic business situation. And for this study the author also wants to clarify that EL, EO, OE and FP are their have relationship have a positive effect for each others.
SYNTHESIS OF 3-HYDROXY-2-NAPHTHOIC ACID ANILIDE CATALYZED BY PHOSPHORUS (III) COMPOUNDS IN VARIOUS MEDIA
Authors: Shteinberg Leon 
Published: June 2023

Catalysis with phosphorus P(III) compo­unds (phosphorus trichloride and phospho­rous acid) in the acylation of aniline with 3=hydroxy=2=naphthoic acid in various media (toluene, octane, chlorobenzene, para=­xylene, ortho=xylene, ortho=chlorotoluene, mesitylene, pseudocumene, n.=deсan, ortho= di­chlo­ro­benzene, mixtures of ortho=xylene with nitrobenzene) upon boiling and vigorous distillation of water leads to the formation of 3=hydroxy=2=naphthoic acid anilide. With an increase in the reaction temperature in the range from 111 (toluene) to 170 °C (pseudo cumene), a monotonous increase in the initial rate of formation of the target product is observed. In this case, the temperature depen­dence of the logarithm of the velocity obeys the Arrhenius equation, and the activation energy Ea is 66.2 kJ/mol.
Higher-boiling n.=decane (175 °С) and ortho=dichlorobenzene (180 °С) fall out of this dependence, in which the initial rate of formation of anilide 3=hydroxy=2=naphthoic acid, compared with that for pseudocumene (170 °С), decreases. The latter may be due to the decomposition or oxidation of the catalyst at such a high temperature with the transition of P(III) to P(V), which does not have catalytic activity.
The interaction of aniline with 3=hydro­xyl=2=naphthoic acid proceeds as a series of sequential and parallel reactions in which, in addition to 3=hydroxyl=2= naphthoic acid ani­lide, 3=aniline=2=naphthoic acid and its anilide are formed as impurities.
The most acceptable solvents are ortho=xylene and ortho=chlorotoluene with boiling points of 146 and 156°C, in which the yield of the target product is up to 98%. Below 146 °C the reaction proceeds at a relatively low rate; above 156°C the amount of impurities increases significantly, mainly in parallel with an increase in the reaction temperature, and the maximum yield of 3=hydroxyl=2=naphthoic acid anilide decreases. This requires its additional purification, significantly complicating the technological process.
The addition of 10–20% by volume of nit­robenzene to ortho=xylene leads to an increase in the yield of 3=oxy=2=naphthoic acid anilide by 1.25–1.42 times in the temperature range of 146–148°C with increasing solvent polarity (ε), respectively, from 2.3 to 7.64. This may be due to an increase in the quantity of the monomers of the catalyst and/or 3=oxy=2=naphthoic acid and aniline in reaction mass and the speed of water separation.
Sustained in vivo perfusion of a re-endothelialized tissue engineered kidney graft in a human-scale animal model
Authors: Uzarski Joseph S. , Beck Emily C. , Russell Emily E. , Vanderslice Ethan J. , Holzner Matthew L. , Wadhera Vikram , Adamson Dylan , Shapiro Ron , Davidow Dominique S. , Ross Jeff J. , Florman Sander S. 
Published: June 2023

Introduction: Despite progress in whole-organ decellularization and recellularization, maintaining long-term perfusion in vivo remains a hurdle to realizing clinical translation of bioengineered kidney grafts. The objectives for the present study were to define a threshold glucose consumption rate (GCR) that could be used to predict in vivo graft hemocompatibility and utilize this threshold to assess the in vivo performance of clinically relevant decellularized porcine kidney grafts recellularized with human umbilical vein endothelial cells (HUVECs).Materials and methods: Twenty-two porcine kidneys were decellularized and 19 were re-endothelialized using HUVECs. Functional revascularization of control decellularized (n = 3) and re-endothelialized porcine kidneys (n = 16) was tested using an ex vivo porcine blood flow model to define an appropriate metabolic glucose consumption rate (GCR) threshold above which would sustain patent blood flow. Re-endothelialized grafts (n = 9) were then transplanted into immunosuppressed pigs with perfusion measured using angiography post-implant and on days 3 and 7 with 3 native kidneys used as controls. Patent recellularized kidney grafts underwent histological analysis following explant.Results: The glucose consumption rate of recellularized kidney grafts reached a peak of 39.9 ± 9.7 mg/h at 21 ± 5 days, at which point the grafts were determined to have sufficient histological vascular coverage with endothelial cells. Based on these results, a minimum glucose consumption rate threshold of 20 mg/h was set. The revascularized kidneys had a mean perfusion percentage of 87.7% ± 10.3%, 80.9% ± 33.1%, and 68.5% ± 38.6% post-reperfusion on Days 0, 3 and 7, respectively. The 3 native kidneys had a mean post-perfusion percentage of 98.4% ± 1.6%. These results were not statistically significant.Conclusion: This study is the first to demonstrate that human-scale bioengineered porcine kidney grafts developed via perfusion decellularization and subsequent re-endothelialization using HUVEC can maintain patency with consistent blood flow for up to 7 days in vivo. These results lay the foundation for future research to produce human-scale recellularized kidney grafts for transplantation.
In silico characterisation of minor wave genes and LINE-1s transcriptional dynamics at murine zygotic genome activation
Authors: Ansaloni Federico , Gustincich Stefano , Sanges Remo 
Published: June 2023

Introduction: In mouse, the zygotic genome activation (ZGA) is coordinated by MERVL elements, a class of LTR retrotransposons. In addition to MERVL, another class of retrotransposons, LINE-1 elements, recently came under the spotlight as key regulators of murine ZGA. In particular, LINE-1 transcripts seem to be required to switch-off the transcriptional program started by MERVL sequences, suggesting an antagonistic interplay between LINE-1 and MERVL pathways.Methods: To better investigate the activities of LINE-1 and MERVL elements at ZGA, we integrated publicly available transcriptomics (RNA-seq), chromatin accessibility (ATAC-seq) and Pol-II binding (Stacc-seq) datasets and characterised the transcriptional and epigenetic dynamics of such elements during murine ZGA.Results: We identified two likely distinct transcriptional activities characterising the murine zygotic genome at ZGA onset. On the one hand, our results confirmed that ZGA minor wave genes are preferentially transcribed from MERVL-rich and gene-dense genomic compartments, such as gene clusters. On the other hand, we identified a set of evolutionary young and likely transcriptionally autonomous LINE-1s located in intergenic and gene-poor regions showing, at the same stage, features such as open chromatin and RNA Pol II binding suggesting them to be, at least, poised for transcription.Discussion: These results suggest that, across evolution, transcription of two different classes of transposable elements, MERVLs and LINE-1s, have likely been confined in genic and intergenic regions respectively in order to maintain and regulate two successive transcriptional programs at ZGA.
Plasma osteoprotegerin predicts adverse cardiovascular events in stable coronary artery disease: the PEACE trial
Authors: Ma Teng , Zhao Jian , Yan Yechao , Liu Junying , Zang Jie , Zhang Yaqi , Ruan Kun , Xu Hong , He Wan 
Published: June 2023

BackgroundOsteoprotegerin (OPG) is a secretory glycoprotein and participates in the progression of atherosclerotic lesions. We aim to explore the relationship between OPG and the prognosis of coronary artery disease (CAD).MethodsPlasma OPG concentrations were measured in 3,766 patients with stable CAD enrolled in the PEACE trial. The PEACE trial (NCT00000558) group followed up the patients and examined their future clinical outcomes.ResultsIn summary, 208 (5.5%) primary outcomes occurred, 295 patients (7.8%) died from all-cause death, 128 (3.4%) died from cardiovascular causes, and 94 (2.5%) experienced heart failure during a median follow-up of 1,892 days. In addition, we found that higher plasma levels of OPG were associated with a higher incidence of all-cause death, cardiovascular death, and heart failure, even after adjusting clinical cofounders.ConclusionIt was demonstrated that elevated plasma OPG levels were associated with an increased incidence of all-cause death, cardiovascular death, and heart failure in patients with stable CAD.Systematic Review Registrationhttps://clinicaltrials.gov/ct2/show/NCT00000558?term=NCT00000558&amp;draw=2&amp;rank=1, identifier: NCT00000558.
Age-based factors modulating the required thyroxine dose to achieve thyrotropin suppression in intermediate-and high-risk papillary thyroid cancer
Authors: Zhou Ruo-Yun , Li Ning , Tan Hai-Long , Tang Neng , Chen Pei , Liu Mian , Ou-Yang Deng-Jie , Qin Zi-En , Ai Lei , Wei Bo , Zhao Ya-Xin , Chang Shi , Huang Peng 
Published: June 2023

BackgroundGuidelines widely recommend thyrotropin suppression to reduce the risk of recurrence in intermediate- and high-risk papillary thyroid cancer (PTC) after total thyroidectomy. However, an insufficient or excessive dosage may result in a number of symptoms/complications especially in older patients.Patients and methodsWe constructed a retrospective cohort including 551 PTC patient encounters. Using propensity score matching and logistic regression models, we determined the independent risk factors affecting levothyroxine therapy at different ages. Our outcomes included: expected TSH level and an unexpected TSH level, which was based on the initial thyroid-stimulating hormone (TSH) goal&lt; 0.1 mIU/L with usual dosage of L-T4 (1.6 μg/kg/day).ResultsFrom our analysis, more than 70% of patients undergoing total thyroidectomy did not achieve the expected TSH level using an empirical medication regimen, and the effect of the drug was affected by age (odds ratio [OR], 1.063; 95% CI, 1.032-1.094), preoperative TSH level (OR, 0.554; 95% CI, 0.436-0.704) and preoperative fT3 level (OR, 0.820; 95% CI, 0.727-0.925). In patients with age &lt; 55 years old, preoperative TSH level (OR, 0.588; 95% CI, 0.459-0.753), and preoperative fT3 level (OR, 0.859; 95% CI, 0.746-0.990) were two independent protective factors, while, in patients with age ≥ 55 years old, only preoperative TSH level (OR, 0.490; 95% CI, 0.278-0.861) was the independent protective factors to achieve expected TSH level.ConclusionOur retrospective analysis suggested the following significant risk factors of getting TSH suppression in PTC patients: age (≥55 years), lower preoperative TSH and fT3 levels.
Development of predictive nomograms clinical use to quantify the risk of diabetic foot in patients with type 2 diabetes mellitus
Authors: Peng Bocheng , Min Rui 
Published: June 2023

ObjectiveThe aim of the study was to explore the risk factors for diabetic foot disease in patients with type 2 diabetes mellitus and to establish and verify the nomogram model of DF risk in patients with T2DM.MethodsThe clinical data of 705 patients with type 2 diabetes who were hospitalized in our hospital from January 2015 to December 2022 were analyzed retrospectively. According to random sampling, the patients were divided into two groups: the training set (DF = 84; simple T2DM = 410) and the verification set (DF = 41; simple T2DM = 170). Univariate and multivariate logistic regression analysis was used to screen the independent risk factors for DF in patients with T2DM in the training set. According to the independent risk factors, the nomogram risk prediction model is established and verified.ResultsLogistic regression analysis showed age (OR = 1.093, 95% CI 1.062–1.124, P &lt;0.001), smoking history (OR = 3.309, 95% CI 1.849–5.924, P &lt;0.001), glycosylated hemoglobin (OR = 1.328, 95% CI 1.173–1.502, P &lt;0.001), leukocyte (OR = 1.203, 95% CI 1.076–1.345, and LDL-C (OR = 2.002, 95% CI 1.463–2.740), P &lt;0.001) was independent risk factors for T2DM complicated with DF. The area of the nomogram model based on the above indexes under the ROC curve of the training set and the verification set is 0.827 and 0.808, respectively; the correction curve shows that the model has good accuracy; and the DCA results show that when the risk threshold is between 0.10–0.85 (training set) and 0.10–0.75 (verification set), the clinical practical value of the model is higher.ConclusionThe nomogram model constructed in this study is of high value in predicting the risk of DF in patients with T2DM and is of reference value for clinicians to identify people at high risk of DF and provide them with early diagnosis and individual prevention.
The mechanism of assortative mating for educational attainment: a study of Finnish and Dutch twins and their spouses
Authors: Gonggrijp Bodine M. A. , Silventoinen Karri , Dolan Conor V. , Boomsma Dorret I. , Kaprio Jaakko , Willemsen Gonneke 
Published: June 2023

Introduction: Assortative mating refers describes a phenomenon in which individuals with similar phenotypic traits are more likely to mate and reproduce with each other; i.e. assortative mating occurs when individuals choose partners based on their similarity or dissimilarity in certain traits.to patterns of non-random mating of spouses leading to phenotypic resemblance. There are various theories about the its underlying mechanisms, which have different genetic consequences.Methods: We analyzed examined two possible mechanisms underlying assortative mating – phenotypic assortment and social homogamy – for educational attainment in two countries utilizing data of mono- and dizygotic twins and their spouses (1,451 Finnish and 1,616 Dutch twin-spouse pairs).Results: The spousal correlations were 0.51 in Finland and 0.45 in the Netherlands, to which phenotypic assortment contributed 0.35 and 0.30, and social homogamy 0.16 and 0.15, respectively.Conclusion: Both social homogamy and phenotypic assortment are important processes in spouse selection in Finland and the Netherlands. In both countries, phenotypic assortment contributes to a greater degree to the similarity of spouses than social homogamy.