bluuebunny/crossref_metadata_2025_split huggingface dataset:
GBA/GBN-position on the feedback of incidental findings in biobank-based research: consensus-based workflow for hospital-based biobanks
Authors: Geiger Joerg , Fuchs Joerg , Starke Madeline , Neumann Michael , Baber Ronny , Nussbeck Sara Y. , Kiehntopf Michael , Specht Cornelia , Illig Thomas , Hummel Michael , Jahns Roland 
Published: February 2023

AbstractIncidental research findings pose a considerable challenge to hospital-based research biobanks since they are acting as intermediaries between healthcare and research. In a joint action the centralized biobank ibdw (Interdisciplinary Bank of Biomaterials and Data Wuerzburg) together with local authorities drafted a coherent concept to manage incidental research findings in full compliance with relevant ethical and data privacy regulations. The concept was developed and elaborated in close collaboration with the German Biobank Alliance (GBA). Comprehensive documentation of all steps guarantees the traceability of the process. By a mandatory assessment of the findings prior to re-identification of the individual concerned, unnecessary measures can be avoided. The individual’s “right not to know” is respected according to the stipulations of the informed consent. As a general principle any communication with the individual occurs exclusively through the hospital and by competent physicians with appropriate knowledge and communication skills. We propose this scheme as a blueprint for reporting workflows for incidental research findings at hospital-based biobanks.
Direct regeneration of degraded lithium-ion battery cathodes with a multifunctional organic lithium salt
Authors: Ji Guanjun , Wang Junxiong , Liang Zheng , Jia Kai , Ma Jun , Zhuang Zhaofeng , Zhou Guangmin , Cheng Hui-Ming 
Published: February 2023

AbstractThe recycling of spent lithium-ion batteries is an effective approach to alleviating environmental concerns and promoting resource conservation. LiFePO4 batteries have been widely used in electric vehicles and energy storage stations. Currently, lithium loss, resulting in formation of Fe(III) phase, is mainly responsible for the capacity fade of LiFePO4 cathode. Another factor is poor electrical conductivity that limits its rate capability. Here, we report the use of a multifunctional organic lithium salt (3,4-dihydroxybenzonitrile dilithium) to restore spent LiFePO4 cathode by direct regeneration. The degraded LiFePO4 particles are well coupled with the functional groups of the organic lithium salt, so that lithium fills vacancies and cyano groups create a reductive atmosphere to inhibit Fe(III) phase. At the same time, pyrolysis of the salt produces an amorphous conductive carbon layer that coats the LiFePO4 particles, which improves Li-ion and electron transfer kinetics. The restored LiFePO4 cathode shows good cycling stability and rate performance (a high capacity retention of 88% after 400 cycles at 5 C). This lithium salt can also be used to recover degraded transition metal oxide-based cathodes. A techno-economic analysis suggests that this strategy has higher environmental and economic benefits, compared with the traditional recycling methods.
Universal epitaxy of non-centrosymmetric two-dimensional single-crystal metal dichalcogenides
Authors: Zheng Peiming , Wei Wenya , Liang Zhihua , Qin Biao , Tian Jinpeng , Wang Jinhuan , Qiao Ruixi , Ren Yunlong , Chen Junting , Huang Chen , Zhou Xu , Zhang Guangyu , Tang Zhilie , Yu Dapeng , Ding Feng , Liu Kaihui , Xu Xiaozhi 
Published: February 2023

AbstractThe great challenge for the growth of non-centrosymmetric 2D single crystals is to break the equivalence of antiparallel grains. Even though this pursuit has been partially achieved in boron nitride and transition metal dichalcogenides (TMDs) growth, the key factors that determine the epitaxy of non-centrosymmetric 2D single crystals are still unclear. Here we report a universal methodology for the epitaxy of non-centrosymmetric 2D metal dichalcogenides enabled by accurate time sequence control of the simultaneous formation of grain nuclei and substrate steps. With this methodology, we have demonstrated the epitaxy of unidirectionally aligned MoS2 grains on a, c, m, n, r and v plane Al2O3 as well as MgO and TiO2 substrates. This approach is also applicable to many TMDs, such as WS2, NbS2, MoSe2, WSe2 and NbSe2. This study reveals a robust mechanism for the growth of various 2D single crystals and thus paves the way for their potential applications.
Clinical relevance of leukocyte-associated endotoxins measured by semi-automatic synthetic luminescent substrate method
Authors: Terayama Mari , Takahashi Gaku , Nonoguchi Maria , Kan Shigenori , Hoshikawa Koichi , Inada Katsuya , Mase Tomohiko 
Published: February 2023

AbstractA newly developed semi-automatic synthetic luminescence substrate (SALS) method for measuring endotoxin was compared with the existing turbidimetric kinetic assay (TKA) using leukocyte-rich plasma to verify its usefulness. As a result, the endotoxin levels by this method were higher than that by the existing assay in most specimens, and the time required for measurement was much shorter. In addition, the leukocyte-rich plasma endotoxin level minus the plasma endotoxin levels were named leukocyte-associated endotoxin, and these levels per one leukocyte were compared. As a result, those levels were highly correlated with the endotoxin measurement levels of leukocyte-rich plasma. The correlation coefficient of SALS method was superior to the existing TKA method, the endotoxin level by this method may be close to true endotoxin levels.
Tin(ii) cations stabilized by non-symmetric N,N′,O-chelating ligands: synthesis and stability
Authors: Novák Miroslav , Turek Jan , Milasheuskaya Yaraslava , Syková Miriam , Dostál Libor , Stalmans Jesse , Růžičková Zdeňka , Jurkschat Klaus , Jambor Roman 
Published: February 2023

A series of novel non-symmetric N,N′,O-chelating ligands 2-(C(R1)=N(C6H3-2,6-iPr2))-6-(R2R3PO)C5H3N were used for the ionization of SnCl2and Sn(OTf)2. The R2R3PO groups showed the strong effect on the stability of the tin(ii) cations.
Cross-linking mass spectrometry for mapping protein complex topologies in situ
Authors: Lee Kitaik , O'Reilly Francis J. 
Published: February 2023

Abstract
Cross-linking mass spectrometry has become an established technology to provide structural information on the topology and dynamics of protein complexes. Readily accessible workflows can provide detailed data on simplified systems, such as purified complexes. However, using this technology to study the structure of protein complexes in situ, such as in organelles, cells, and even tissues, is still a technological frontier. The complexity of these systems remains a considerable challenge, but there have been dramatic improvements in sample handling, data acquisition, and data processing. Here, we summarise these developments and describe the paths towards comprehensive and comparative structural interactomes by cross-linking mass spectrometry.
High-density liquid (HDL) adsorption at the supercooled water/vapor interface and its possible relation to the second surface tension inflection point
Authors: Gorfer Alexander , Dellago Christoph , Sega Marcello 
Published: February 2023

We investigate the properties of water along the liquid/vapor coexistence line in the supercooled regime down to the no-man’s land. Extensive molecular dynamics simulations of the TIP4P/2005 liquid/vapor interface in the range 198–348 K allow us to locate the second surface tension inflection point with a high accuracy at 283 ± 5 K, close to the temperature of maximum density. This temperature also coincides with the appearance of a density anomaly at the interface known as the apophysis. We relate the emergence of the apophysis to the observation of high-density liquid (HDL) water adsorption in the proximity of the liquid/vapor interface.
Development of a piezoelectric actuator based on stick–slip principle inspired by the predation of snake
Authors: Wang Liang , Wang Heran , Zhang Yaxun , Qiu Zhanbao , Cheng Tinghai 
Published: February 2023

A new piezoelectric actuator based on the stick–slip working principle inspired by the predation of the snake is proposed and developed in this work. A lead zirconate titanate (PZT) stack is used and inserted into the stator with an asymmetric configuration. Then, the elongation of the PZT stack can be transmitted into the vertical and horizontal displacements on the driving foot. They are used to press and drive the slider, respectively. In this design, the motion of the actuator imitates the predation process of the snake. The principle of the proposed actuator is clarified in detail. The statics characteristics are conducted by using the FEM method. The dynamics model of the actuator was established to show the motion behavior of the slider in theory. Finally, the output characteristics of the developed piezoelectric actuator are tested. The results stated that this actuator obtained the maximum output speed of 11.44 mm/s under a voltage of 100 V and a frequency of 600 Hz. The output force of the developed actuator was 2.8N under the preload force of 3N. In conclusion, the feasibility of the proposed piezoelectric stick–slip type actuator inspired by the predation of the snake is verified.
How agricultural practices affect the risk of human contamination by infectious pathogens: the need for a ‘One Health’ perspective
Authors: Ratnadass Alain , Sarter Samira 
Published: February 2023

Abstract

We conducted a comprehensive literature review with a global geographic scope, of interactions between agricultural crop production practices (excluding crop protection practices) and biological human health hazards. The majority of relevant references dealt with bacterial contaminations and infections, largely due to the important public health issue of antibiotic resistance. Indicator coliforms were particularly significant (only a minority mentioned harmful
Escherichia coli
strains), followed by species belonging to
Salmonella
,
Campylobacter
,
Clostridia
,
Pseudomonas
, and
Listeria
genera. Protozoan
Cryptosporidium
spp. and
Giardia
spp., and helminthic
Ascaris
spp. and
Trichuris
spp. dominated the references to parasites. Enteric viruses largely dominated the references to viruses (particularly noroviruses and rotaviruses). Very few references mentioned human fungal pathogens. Fresh vegetables were the most commonly mentioned crops, particularly leafy greens and those eaten raw, due to the use of wastewater for irrigation, and fertilization with livestock manure and human excreta/sewage sludge, potentially unsafe practices. While earlier literature reviews have shown that crop protection practices are central to the One Health concept, this review shows that other agricultural practices can also contribute to human and environmental health
via
different pathways, including better soil health, water quality, better food safety, and human nutrition. Our review underlines that besides tradeoffs, synergies should be sought, between, on the one hand, saving/preserving freshwater and organic waste recycling (affecting environmental health and some aspects of human health), and health hazards associated with the use of potentially contaminated waste on the other (affecting other aspects of human health), from both agroecological and One Health perspectives.
Quasi-bound atoms in collective dynamics of liquid Sb
Authors: Bryk T , Ilenkov I-M , Seitsonen A P 
Published: February 2023

Abstract
We report an ab initio simulation and theoretical study of collective dynamics in liquid Sb at 973 K. An application of the GCM (generalized collective modes) theoretical approach to analysis of simulation-derived time correlation functions resulted in two types of propagating eigenmodes. We found that the almost flat dispersion of the high-frequency branch of propagating modes can be explained by out-of-phase oscillations of nearest neighbors which form quasi-bound atomic pairs for at least 30 ps. We discuss the features of collective dynamics in non-simple metallic melts containing quasi-bound pairs.
Effects of sericin and egg white on the inflammation of damaged skin in mice
Authors: He Mei-Ling , Dong Xuan , Zuo Ling-Li , Niu Ya-Yan , Wang Hai-Yan 
Published: February 2023

Abstract
Sericin and egg white (EW) have shown the ability to promote wound healing. However, there have been insufficient studies regarding the effects of sericin and EW mixtures on wound healing. This study aimed to investigate the effects of a hybrid sericin and EW solution on wound repair and inflammation-related indicators in mouse skin. In this work, sericin with a low molecular weight was first mixed with homogeneous EW to prepare a hybrid wound dressing. Histology evaluation, the expression of C-reactive protein (CRP) and inflammatory cytokines in mice were tested to determine the effects of this dressing on skin injuries in mice. The results showed that sericin and the hybrid solution of sericin and EW effectively promoted wound healing in mouse skin. The wound recovery rates of mice 12 days after treatment with a medium dose of sericin (0.2 g ml−1) and the same dosage of sericin with added EW were 1.32 and 1.65 times that of mice treated with phosphate buffer saline as a control, respectively. In addition, the mixture solution was more effective in wound healing than sericin alone. Sericin with EW significantly reduced the expression of CRP and inflammatory cytokines in mice during wound healing. A sericin and EW hybrid solution can effectively shorten the time needed for wound healing and reduce inflammation-related indicators in mice, making it a promising candidate for wound dressing.
To be and not to be: wide-field Ca2+ imaging reveals neocortical functional segmentation combines stability and flexibility
Authors: Nietz Angela K , Streng Martha L , Popa Laurentiu S , Carter Russell E , Flaherty Evelyn B , Aronson Justin D , Ebner Timothy J 
Published: February 2023

AbstractThe stability and flexibility of the functional parcellation of the cerebral cortex is fundamental to how familiar and novel information is both represented and stored. We leveraged new advances in Ca2+ sensors and microscopy to understand the dynamics of functional segmentation in the dorsal cerebral cortex. We performed wide-field Ca2+ imaging in head-fixed mice and used spatial independent component analysis (ICA) to identify independent spatial sources of Ca2+ fluorescence. The imaging data were evaluated over multiple timescales and discrete behaviors including resting, walking, and grooming. When evaluated over the entire dataset, a set of template independent components (ICs) were identified that were common across behaviors. Template ICs were present across a range of timescales, from days to 30 seconds, although with lower occurrence probability at shorter timescales, highlighting the stability of the functional segmentation. Importantly, unique ICs emerged at the shorter duration timescales that could act to transiently refine the cortical network. When data were evaluated by behavior, both common and behavior-specific ICs emerged. Each behavior is composed of unique combinations of common and behavior-specific ICs. These observations suggest that cerebral cortical functional segmentation exhibits considerable spatial stability over time and behaviors while retaining the flexibility for task-dependent reorganization.
Income-Based Affirmative Action in College Admissions
Authors: Brotherhood Luiz , Herskovic Bernard , Ramos João 
Published: February 2023

Abstract
We study whether college admissions should implement quotas for lower-income applicants. We develop an overlapping-generation model and calibrate it to data from Brazil, where such a policy is widely implemented. In our model, parents choose how much to invest in their child’s education, thereby increasing both human capital and likelihood of college admission. We find that, in the long run, the optimal income-based affirmative action increases welfare and aggregate output. It improves the pool of admitted students, but distorts pre-college educational investments. The welfare-maximising policy benefits lower- to middle-income applicants with income-based quotas, while higher-income applicants face fiercer competition in college admissions. The optimal policy reduces intergenerational persistence of earnings by 5.7% and makes nearly 80% of households better off.
Pregnancy outcomes in women with heart disease: the Madras Medical College Pregnancy And Cardiac (M-PAC) Registry from India
Authors: Justin Paul Gnanaraj , Anne Princy Steaphen , Anju Surendran , Anita Susikar , Cecily Mary Majella , Gnanavelu Ganesan , Kanmani Kandasamy , Meena Mahalingam , Nandakumaran Mohanan , Ramya Swaminathan , Ravishankar Govindarajulu , Shaanthi Gunasingh , Shoba Somasundaram , Sangareddi Venkatesan , Vijaya Subramanian ,   the M-PAC investigators, Gomathy  , Geetha  , Rani Usha , Selvi N Tamil , Sarala  , Selvi B Tamil , Elizabeth Prema , Nalina  , Priyadarsene  , Kasthuri  , Sadhana  , Sindhumathy  , Sudarshini  , Nazreeen  , Devika  , Sivakumar Shoba , Umarani C , Priya R , Kaleeswari  , Suganya  , Shunmugam Ravi Marimuthu , Ganapathy Palaniswamy , Chandran Moorthy , Nagarajan Swaminathan , Ganesan Manohar , Angappamudali Arumugam Moongilpatti , Jeyabalan Nambirajan , Palani Balaji Pandian , Saravanababu  , Srinivasan Kumaran , Elangovan Elavarasi Manimegalai , Mohandoss Nageswaran Piskala , Chandrasekaran Elangovan , Duraipandian Rajasekar Ramesh , Gorijavaram Pratap Kumar , Kunjjitham Tamilselvan , Ravindran  , Dharmarajan  , Kaliyamurthy Thiagarajan , Sreeram Jeyalaxmi , Seeralan Arasar , Mangalabharathi  , Mariappan Baliah , Manimaran Chandrika , kumar Ebenezer Joel 
Published: February 2023

Abstract

Aims
To evaluate the feto-maternal outcome, identify the adverse outcome predictors and test the applicability of modified WHO (mWHO) classification in pregnant women with heart disease (PWWHD) from Tamil Nadu, India.

Methods and results
One thousand and five pregnant women (mean age: 26.04 ± 4.2) with 1029 consecutive pregnancies were prospectively enrolled from July 2016 to December 2019 in the Madras medical college pregnancy and cardiac (M-PAC) registry. Majority (60.5%; 623/1029) had heart disease (HD) diagnosed for the first time during pregnancy. Rheumatic HD (42%; 433/1029) was most common. One third (34.2%; 352/1029) had pulmonary hypertension (PH). Maternal mortality and composite maternal cardiac events (MCEs) were the primary outcomes. Secondary outcomes were foetal loss and composite adverse foetal events (AFEs). MCEs occurred in 15.2% (156/1029; 95% CI: 13.0–17.5) pregnancies. Heart failure was the most common MCE (66.0%; 103/156; 95% CI: 58.0–73.4). Maternal mortality was 1.9% (20/1029; 95% CI: 1.1–2.8), with highest rates in patients with prosthetic heart valves (PHVs) (8.6%; 6/70). Left ventricular systolic dysfunction (LVSD), PHVs, severe mitral stenosis, PH and current pregnancy diagnosis of HD were independent predictors of MCE. The c-statistic of mWHO classification for predicting MCE and maternal death were 0.794 (95% CI: 0.763–0.826) and 0.796 (95% CI: 0.732–0.860). 91.2% (938/1029; 95% CI: 89.392.8) of pregnancies resulted in live births. 33.7% (347/1029; 95% CI: 30.8–36.7) of pregnancies reported AFEs.

Conclusion
Maternal mortality is high in PWWHD from India. Highest death rates occurred in women with PHVs, PH and LVSD. The mWHO classification for risk stratification may require further adaptation and validation in India.
Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration
Authors: Nollet Edgar E , Duursma Inez , Rozenbaum Anastasiya , Eggelbusch Moritz , Wüst Rob C I , Schoonvelde Stephan A C , Michels Michelle , Jansen Mark , van der Wel Nicole N , Bedi Kenneth C , Margulies Kenneth B , Nirschl Jeff , Kuster Diederik W D , van der Velden Jolanda 
Published: February 2023

AbstractAimsGenetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitochondrial dysfunction is thought to be a key driver of pathological remodelling in HCM. Reports of mitochondrial respiratory function and specific disease-modifying treatment options in patients with HCM are scarce.Methods and resultsRespirometry was performed on septal myectomy tissue from patients with HCM (n = 59) to evaluate oxidative phosphorylation and fatty acid oxidation. Mitochondrial dysfunction was most notably reflected by impaired NADH-linked respiration. In genotype-negative patients, but not genotype-positive patients, NADH-linked respiration was markedly depressed in patients with an indexed septal thickness ≥10 compared with &lt;10. Mitochondrial dysfunction was not explained by reduced abundance or fragmentation of mitochondria, as evaluated by transmission electron microscopy. Rather, improper organization of mitochondria relative to myofibrils (expressed as a percentage of disorganized mitochondria) was strongly associated with mitochondrial dysfunction. Pre-incubation with the cardiolipin-stabilizing drug elamipretide and raising mitochondrial NAD+ levels both boosted NADH-linked respiration.ConclusionMitochondrial dysfunction is explained by cardiomyocyte architecture disruption and is linked to septal hypertrophy in genotype-negative HCM. Despite severe myocardial remodelling mitochondria were responsive to treatments aimed at restoring respiratory function, eliciting the mitochondria as a drug target to prevent and ameliorate cardiac disease in HCM. Mitochondria-targeting therapy may particularly benefit genotype-negative patients with HCM, given the tight link between mitochondrial impairment and septal thickening in this subpopulation.
Epicardial vs. transvenous implantable cardioverter defibrillators in children
Authors: Le Bos Pierre Antoine , Pontailler Margaux , Maltret Alice , Kraiche Diala , Gaudin Regis , Barbanti Claudio , Marijon Eloi , Raisky Olivier , Bonnet Damien , Waldmann Victor 
Published: February 2023

AbstractAimsThe implantable cardioverter defibrillator (ICD) has been increasingly used in children. Both epicardial and transvenous approaches are used, with controversy regarding the best option with no specific recommendations. We aimed to compare outcomes associated with epicardial vs. transvenous ICDs in children.Methods and resultsData were analysed from a retrospective study including all patients &lt;18-year-old implanted with an ICD in a tertiary centre from 2003 to 2021. Outcomes were compared between epicardial and transvenous ICDs. A total of 122 children with an ICD (mean age 11.5 ± 3.8 years, 57.4% males) were enrolled, with 84 (64.1%) epicardial ICDs and 38 (29.0%) transvenous ICDs. Early (&lt;30 days) ICD-related complications were reported in 17 (20.2%) patients with an epicardial ICD vs. 0 (0.0%) with a transvenous ICD (P = 0.002). Over a mean follow-up of 4.8 ± 4.0 years, 25 (29.8%) patients with an epicardial ICD and 9 (23.7%) patients with a transvenous ICD experienced at least one late ICD-related complication [hazard ratio (HR) 1.8, 95% confidence interval (CI) 0.8–4.0]. Implantable cardioverter defibrillator lead dysfunction occurred in 19 (22.6%) patients with an epicardial ICD vs. 3 (7.9%) with a transvenous ICD (HR 5.7, 95% CI 1.3–24.5) and was associated with a higher incidence of ICD-related reintervention (HR 3.0, 95% CI 1.3–7.0). After considering potential confounders, especially age and weight at implantation, this association was no longer significant (P = 0.112). The freedom from ICD lead dysfunction was greater in patients with pleural coils than in those with epicardial coils (HR 0.38, 95% CI 0.15–0.96).ConclusionIn children, after a consideration of patient characteristics at implantation, the burden of complications and ICD lead dysfunction appears to be similar in patients with epicardial and transvenous devices. Pleural coils seem to be associated with better outcomes than epicardial coils in this population.Clinical Trial RegistrationNCT05349162.