bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpretable Machine Learning-based Individual Analysis of Acute Kidney Injury in Immune Checkpoint Inhibitor Therapy
Authors: Sakuragi Minoru , Uchino Eiichiro , Sato Noriaki , Matsubara Takeshi , Ueda Akihiko , Mineharu Yohei , Kojima Ryosuke , Yanagita Motoko , Okuno Yasushi 
Published: April 2023

Abstract
Acute kidney injury (AKI) is a critical complication in immune checkpoint inhibitor (ICI) therapy. Although risk factors of AKI in ICI therapy have been extensively studied, individualized and real-time assessment of AKI risk has not been achieved. We aimed to clarify the underlying causes of individual AKI in ICI-treated patients using a novel time-series clustering approach with Shapley Additive exPlanations (SHAP) values and decision tree-based machine learning (ML) prediction models. The medical records of 616 cancer patients receiving ICI therapy were used for model construction, and 112 patients (18.2%) had at least one AKI episode. They were clustered per key features and their SHAP value patterns, and three nephrologists assessed the clusters’ clinical relevance. Receiver operating characteristic analysis revealed that the area under the curve was 0.880. Patients with AKI were categorized into four clusters with significant prognostic differences (p = 0.010). The leading causes of AKI (such as hypovolemia, drug-related, and cancer cachexia) for each cluster were interpretable by nephrologists. These results suggest that our clustering method of time-series SHAP values can clarify the underlying background of AKI in ICI-treated patients and possibly be used for personalized AKI risk assessment and early intervention for improved outcomes.
Fingertip Coverage with uni-pedicled volar rotational advancement flap with large Z-plasty; a report on 112 cases
Authors: Park Seong Oh , Kim Dae Kwan , Ahn Hee Chang , Kim Youn Hwan 
Published: April 2023

Abstract
Background Simple and safe fingertip reconstruction methods involve the use of local neurovascular islands flaps that can preserve functional length and sensitivity, and reconstruction with skin of the same texture. However, techniques involving flaps have numerous drawbacks and do not satisfy all the requirements for fingertip reconstruction. A particular problem is the persistence of contracture deformity due to lack of full flap advancement. We present a new technique using uni-pedicled volar rotational advancement flap with large Z-plasty, and describe the results of long-term follow-up.Methods From October 1993 to December 2009, 112 fingers of 98 patients were covered with uni-pedicled volar rotational advancement flap with large Z-plasty after sustaining various types of injuries or finger pulp avulsion. A longitudinal incision was made along the lateral border of the digit and a large neurovascular volar flap was elevated just above the pulleys and flexor tendon sheath. To release tension, a large Z-plasty was applied at the metacarpophalangeal joint or interphalangeal joint crease. The final patient outcomes were reviewed retrospectively.Results All fingertip injuries were treated without flap necrosis. Partial wound dehiscence was observed in two patients and average static two-point discrimination was 5.2 mm. There were no postoperative contracture deformities, joint stiffness, paresthesia, or hypersensitivity. Most patients were left with acceptable scarring and were free of postoperative pain and cold intolerance during the long-term follow-up.Conclusions Our novel technique provides durable, completely sensate, and well-vascularized coverage of the fingertip with minimal discomfort to patients.
Design of personalized nasal catheter fixation device based on laser engraving technology and evaluation of its application effect
Authors: Wang Min , Li Fanfan , Wang Ting , Wang Panpan , Ma Guojing , Qin Yue , Wang Xiaolan , Zhao Dan , Ma Minjie , Ma Xiaoli 
Published: April 2023

Abstract

Background: A historical controlled study method to compare the effectiveness of laser engraved personalized nasal cannula fixation devices with conventional cut nasal patches for fixing nasogastric tubes after esophageal cancer surgery.
Methods: One hundred and twenty-four patients with indwelling nasal catheters for esophageal cancer surgery in a tertiary care hospital in Lanzhou were selected as study subjects and divided into control and observation groups according to the historical control study method, with 62 patients in each group. The control group used conventionally cut nasal patches to fix the nasal ducts, and the observation group used laser-engraved personalized nasal patches to fix the nasal ducts. The rate of catheter displacement or slippage under the fixation device, the number of rolled edges and replacement of nasal patches, nasal medical device related pressure injury and pre-injury condition, medical adhesive related skin injury, and patient comfort condition were observed in both groups.
Results: The rate of nasal catheter displacement in the observation group was lower than that in the control group (P < 0.05). The number of rolled edges and replacement of nasal patches in the observation group were lower than those in the control group (P < 0.05). The incidence of nasal mucosal indentation, nasal pain, and medical adhesive-related skin lesions in the observation group was lower than that in the control group (P < 0.05). The physiological level of comfort of patients in the observation group was better than that in the control group (P < 0.05).
Conclusion: Laser engraved personalized nasal cannula fixation devices have better clinical value than conventional cut nasal patches. It can reduce the incidence of clinical nasal catheter displacement, the frequency of rolled edges and replacement of nasal patches, reduce the incidence of nasal medical device related pressure injuries and medical adhesive related skin injuries, and increase patient comfort.
Spectra of triply heavy Ωccb and Ωbbc baryons
Authors: Shah Zalak , Kakadiya Amee , Rai Ajay kumar 
Published: April 2023

Abstract
We determine the spectroscopic properties of triply charm-bottom baryons in this paper. The mass spectra of Ωccb and Ωbbc are calculated with total spin S = 1/2 and 3/2. All possible states with JP values are calculated and compared with the available literature. The Regge trajectories are also plotted. The magnetic moments, magnetic transition moment, and radiative decay widths are also calculated.
Surgical resection for liver recurrence after curative resection of pancreatic ductal adenocarcinoma
Authors: Shibata Yoshiyuki , Uemura Kenichiro , Sumiyoshi Tatsuaki , Okada Kenjiro , Otsuka Hiroyuki , Serikawa Masahiro , Ishii Yasutaka , Murakami Yoshiaki , Arihiro Koji , Takahashi Shinya 
Published: April 2023

Abstract
Purpose This study aimed to evaluate the clinical significance of surgical resection for liver recurrence in patients with curatively resected pancreatic ductal adenocarcinoma.Methods The medical records of patients who had a liver recurrence after undergoing curative pancreatectomy for pancreatic ductal adenocarcinoma were retrospectively reviewed. Clinicopathological and prognostic factors were analyzed, as was the clinical impact of surgical resection for liver recurrence.Results Overall, 502 patients underwent curative pancreatic ductal adenocarcinoma resection. Of the 311 patients with recurrence after curative pancreatectomy, 71 (23%) had an initial recurrence in the liver, with 35 having solitary recurrence (11%). Patients with solitary, two or three, or > four recurrences had median overall survival times of 28.5, 18.0, and 12.2 months, respectively (p < 0.001). Surgical indications for liver recurrence in our institution included solitary tumor, good disease control under chemotherapy after recurrence for > 6 months, and sufficient remnant liver function. Ten patients who met our institutional policy inclusion criteria underwent liver resection. In 35 patients with initially solitary liver recurrence, those who underwent liver resection outlived those who did not (57.6 months vs. 20.1 months, p < 0.001). In multivariate analysis of overall survival, solitary liver recurrence, and liver resection were independent favorable prognostic factors in patients with initial liver recurrence.Conclusion In selected patients with solitary liver recurrence after curatively resected pancreatic ductal adenocarcinoma, liver resection may be a treatment option.
Real-Time Tracking of Moving Objects through Efficient Scale Space Adaptation and Normalized Correlation Filtering
Authors: Ali Asfak , Ghosh Avra , Chaudhuri Sheli Sinha 
Published: April 2023

Abstract
The field of real-time mobile object tracking is a crucial aspect of computer vision. Despite numerous algorithms proposed for efficient tracking, the high computational complexity presents challenges in achieving real-time performance. This paper presents a novel approach by introducing an adaptive search region proposal block that works in tandem with Mean Shift and Unscented Kalman Filter. The block efficiently searches the region of the estimated object location. The dynamic changes in the appearance and size of a moving target make tracking difficult, but the proposed Multi-scale Template Matching technique addresses this challenge by utilizing the Normalized Cross-Correlation method in the adaptive search region. This optimization results in a reduced computational complexity and an increased frame rate of 53.4 FPS. Additionally, the approach leads to a 50.3% decrease in error rate and improved precision and success rates of 76% and 79% respectively. Comparisons with various state-of-the-art trackers show that the proposed algorithm achieves the best results in terms of precision, success rate, and object tracking error.
Daily smoking prevalence for small domains in Australia
Authors: Das Sumonkanti , Baffour Bernard , Richardson Alice , Cramb Susanna , Haslett Stephen 
Published: April 2023

Abstract

Small area statistics on health outcomes like daily smoking prevalence are vital for measuring
community progress towards healthy lifestyles. Due to sparse data and remoteness in Australia,
the National Health Survey is insufficient to estimate at the disaggregated statistical areas (SA)
in Australia, even sometimes at the sub-national level. This study estimates daily smoking
prevalence for Australian adults at various sub-national levels comprising 8 States and Territories,
88 Statistical Areas Level 4 (SA4s), and 334 Statistical Areas Level 3 (SA3s) by extending
widely used area-level models developed at the detailed SA3 level as a form of hierarchical
Bayesian model and fitted by Markov Chain Monte Carlo simulation. Detailed level direct
estimates with their smoothed standard errors from the 2017-18 National Health Survey are
used as model inputs. Area-level models accounting for the detailed level structured (spatial)
and unstructured (non-spatial) random effects provide slightly higher bias and lower coverage
at the disaggregated SA4 level. An extension of area-level models by including intermediate
(SA4) level non-spatial random effects is proposed to improve the unbiasedness and coverage
of the model-based estimators at higher aggregation levels and is found to be suitable for the
Australian smoking prevalence data through examination of model performance statistics.
Magnetohydrodynamic Mixed Convection in a Vertical Rectangular Cavity with Semi-circular Heat Source and Circular Obstacle
Authors: Akhtar Pushpa , Hossain M. M. Touhid , Alim Md. Abdul , Ali Mohammad Mokaddes 
Published: April 2023

Abstract
A study of MHD mixed convection in a vertical rectangular cavity with semi-circular heat source and circular obstacles is accomplished numerically. A semi-circular heat source is placed at the middle of the bottom wall of the cavity and the top wall of the cavity is kept isothermally cooled while other walls are considered adiabatic. Moreover, a hollow circular cylinder is also placed as an obstruction at the center of the cavity. Finite element method is applied to determine a numerical solution of the non-linear coupled equations. Computations have been carried out for the flow and thermal fields inside the cavity which inclusively depends on the applied magnetic field parameter called Hartmann number (Ha) and other dimensionless numbers such as Reynolds number (Re), Richardson number (Ri) and Prandtl number (Pr). From this analysis it is observed that the fluid flow in the cavity is noticeably slowed down by the increase in Ha, heat transfer rate is significantly increased for increasing Re and Ri, but it decreased for increasing the values of Pr and Ha. In addition, the average temperature within the cavity shows opposite behaviors for variations in physical parameters studied except for Ha.
Synthesis ,Growth , Thermal and Third-order nonlinear optical studies of Bisglycine Lithium Perchlorate Single Crystal
Authors: Revathi P. , George Merin , Philip Bessy Mary , Nair Sutheertha S. , Jose Bibin K. , Shereena Elsy , Ittyachan Reena , Balakrishnan T. , Sajan D. 
Published: April 2023

Abstract

We herein record the synthesis as well as the results of our investigations on the structure as well as properties - thermal, mechanical, surface and nonlinear optical (NLO) - of semiorganic bisglycine lithium perchlorate (BGLP) single crystals. BGLP single crystal with dimensions 14× 3 × 2 mm3 has been synthesized and its structure and lattice parameters have been identified with the aid of X-ray diffraction. The vibrational spectrum of BGLP has been investigated making use of FT-IR and FT-Raman spectra. Dielectric constant of BGLP is found to show variations with frequency as well as temperature, which remains constant at high frequencies, the causes of which have been discussed. BGLP is manifested to be thermally stable up to 256ºC as revealed from thermogravimetric analyses. The two-dimensional nucleation mechanism in the growth of BGLP crystals have been understood from chemical etching studies. The potential applications of BGLP in optical switching is evident from its third order NLO response seen in the Z-scan curves.
Survival analysis of laparoscopic surgery and open surgery for hilar cholangiocarcinoma: a retrospective cohort study
Authors: Yin Yaolin , Tao Jilin , Xian Yin , Li Yonghe , Li Qiang , Xiong Yongfu , Huang Xujian , He Yi , He Kun , Li Jingdong 
Published: April 2023

Abstract

PurposeThis study compared the clinical efficacy and safety of laparoscopic versus open resection for hilar cholangiocarcinoma (HCCA) and analyzed potential prognostic factors.MethodsThe study included patients who underwent HCCA resection at our center from March 2012 to February 2022. Perioperative complications and postoperative prognosis were compared between the laparoscopic surgery (LS) and open surgery (OS) groups.ResultsAfter screening 313 HCCA patients, 68 patients were eligible for the study in the LS group (n = 40) and OS group (n = 28). Kaplan-Meier survival curve analysis revealed that overall survival > 2 years and 3-year disease-free survival (DFS) were more common in the LS than OS group, but the rate of 2-year DFS was lower in the LS group than OS group. Cox multivariate regression analysis revealed age (< 65 years), radical resection, and postoperative adjuvant therapy were associated with reduced risk of death (hazard ratio [HR] = 0.380, 95% confidence interval [CI] = 0.150–0.940,P = 0.036; HR = 0.080, 95% CI = 0.010–0.710,P = 0.024 and HR = 0.380, 95% CI = 0.150–0.960,P = 0.040), whereas preoperative biliary drainage was an independent factor associated with increased risk of death (HR = 2.810, 95% CI = 1.130–6.950,P = 0.026). Perineuronal invasion was identified as an independent risk factor affecting DFS (HR = 5.180, 95% CI = 1.170–22.960,P = 0.030).ConclusionsCompared with OS, laparoscopic HCCA resection does not significantly differ in terms of clinical efficacy. Age (< 65 years), radical resection, and postoperative adjuvant therapy reduce the risk of death, and preoperative biliary drainage increases the risk of death.
Crystal chemistry and thermodynamic properties of zircon structure-type materials
Authors: Strzelecki Andrew C. , Zhao Xiaodong , Estevenon Paul , Xu Hongwu , Dacheux Nicolas , Ewing Rodney C. , Guo Xiaofeng 
Published: April 2023

Abstract
Zircon-class ternary oxide compounds have an ideal chemical formula of ATO4, where A is commonly a lanthanide and an actinide, with T = As, P, Si, or V. Their structure (I41/amd) accommodates a diverse chemistry on both A- and T-sites, giving rise to more than 17 mineral end-members of five different mineral groups, and in excess of 45 synthetic end-members. Because of their diverse chemical and physical properties, the zircon structure-type materials are of interest to a wide variety of fields and may be used as ceramic nuclear waste forms and as aeronautical environmental barrier coatings, to name a couple. To support advancement of their applications, many studies have been dedicated to the understanding of their structural and thermodynamic properties. The emphasis in this review will be on recent advances in the structural and thermodynamic studies of zircon structure-type ceramics, including pure end-members [e.g., zircon (ZrSiO4), xenotime (YPO4)] and solid solutions [e.g., ErxTh1–x(PO4)x(SiO4)1–x]. Specifically, we provide an overview on the crystal structure, its variations and transformations in response to non-ambient stimuli (temperature, pressure, and radiation), and its correlation to thermophysical and thermochemical properties.
The Encyclopedia of Female Pioneers in Online Learning, 2023.
Authors: Janes Diane P. 
Published: April 2023

The Encyclopedia of Female Pioneers in Online Learning by Drs. Susan Bainbridge and Norine Wark is an overview of the work and experiences of 30 women - early adopters of online (OL) and distance education (DE) in their countries (although even they struggle with what to call their focus of study and practice, as discussed in Chapter 32). Building on the use of “…career profiles, original interviews, and research analysis…” (p. 1), the book is a testament to the space that women in this field, have occupied and continue to occupy in the modern-day world of technology enhanced global education. The book is divided into two parts.
Molecular marker technologies in food plant genetic diversity studies: An overview
Authors: Aslanbay Guler Bahar , Imamoglu Esra 
Published: April 2023

Marker-assisted technologies in the field of plant biotechnology have attracted great interest of scientists seeking to determine the genetic variety and improve specific characteristics of species. Among several types, molecular markers hold great promise due to their high efficiency, adequate accuracy, and good reproducibility. This review aimed to present different molecular markers used in genetic biodiversity studies of common food plants, including potato, corn, and tomato.
We presented some of the most frequent molecular markers in terms of their methodologies, advantages, challenges, and applications. We also reviewed the latest advances in the genetic diversity studies of common food plants that contribute to agricultural activities.
According to latest progress, Simple Sequence Repeats, Sequence Characterized Amplified Region, and Single Nucleotide Polymorphism are the most common molecular markers in plant diversity studies due to their co-dominancy, high level of polymorphism, great reproducibility, and adequate specificity. Considering common food plants like potato, corn, and tomato, Simple Sequence Repeats and Single Nucleotide Polymorphisms provide detailed information about polymorphisms, resistance to pathogens or diseases, genome maps, and population dynamics. However, more research should be conducted to apply the latest and more efficient technologies, such as Next Generation Sequencing, Diversity Array Technologies, and omics, to the genetic diversity studies of plant species.
Within the scope of recent progress, this review has a strong potential in providing relevant material for further research. It can serve as a guide to adopt the latest and most efficient sequencing platforms for examining various plant species, primarily potato, corn, and tomato.
Hyptis suaveolens L. leaf extracts in traditional health care systems
Authors: Akharaiyi Fred Coolborn , Ehis-Eriakha Chioma Bertha , Olagbemide Peter Taiwo , Igbudu Faith Hukwu 
Published: April 2023

Hyptis suaveolens L. is a medical and food plant that is commonly used to treat various microbial infections in humans in many countries of the world. We aimed to study the aqueous and ethanol extracts of H. suaveolens leaves to determine their antibacterial, in-vitro antioxidant, and phytochemical potentials for traditional medicine by using chemical analysis.
The aqueous and ethanol extracts inhibited the tested bacteria species with zones of 0–15 and 10–29 mm, respectively. On the typed culture isolates, the inhibition zones were 8–25 and 16–32 mm for the aqueous and ethanol extracts, respectively.
The minimum inhibitory concentrations of the aqueous and ethanol extracts were not different, while the minimum bactericidal concentrations for the aqueous extract was higher than that for the ethanol extract. The screened phytochemicals were qualitatively and quantitatively present in both extracts, except for saponins which were absent in the aqueous extract. The free radical scavenging activity in the aqueous and ethanol extracts was 1.44 ± 0.50 and 1.57 ± 1.40 mg of ascorbic acid/1 g dry leaves, respectively. The ferric reduction was 1.19 ± 0.40 and 1.69 ± 0.18 mg of ascorbic acid/1 g dry leaves in the aqueous and ethanol extracts, respectively. Hydroxyl scavenging was 65.0 ± 0.9 and 0.43 ± 0.50 mg of ascorbic acid/1 g dry leaves for the aqueous and ethanol extracts, respectively.
The present research suggests that the extract of H. suaveleons can be applied as a controlling antibacterial growth agent against Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Streptococcus pneumoniae and other bacterial pathogens. It is noteworthy that the ethanol extract was more effective than the aqueous one in terms of the antibacterial, phytochemical and antioxidant activities.