bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supra‐physiological doses of anabolic androgenic steroids impact erythropoietin and blood parameters
Authors: Heiland Carmel E. , Schickel Yasmin , Lehtihet Mikael , Börjesson Annica , Ekström Lena 
Published: February 2023

AbstractHematological parameters and erythropoiesis are known to be influenced by anabolic androgenic steroid (AAS) use. However, little is known in relation to supra‐physiological doses of AAS. Therefore, the aim of this study was to evaluate the effect of supra‐physiological doses of AAS on serum and urinary erythropoietin (EPO), and blood parameters, from self‐reported AAS users. Serum EPO levels were higher in testosterone positive AAS users (11.83 mIU/mL ± 4.19) than nonpositive (6.60 mIU/mL ± 2.70, p = 0.03), while no differences in urinary EPO levels were noted. There were positive correlations between serum EPO and testosterone levels (rs = 0.46, p = 0.01) and reticulocyte percentage (rs = 0.43, p = 0.02). Individuals with AAS‐induced hypogonadism (ASIH; luteinizing hormone levels <1.4 IU/L) had approximately 75% higher serum EPO (p < 0.05) and 140% higher high fluorescence reticulocyte fractions (p < 0.001), as well as other affected hematological parameters, compared with non‐ASIH individuals. The results extend the knowledge of how endocrine and hematological biomarkers are affected by AAS doping.
Suppressing the Undesirable Energy Loss in Solution‐Processed Hyperfluorescent OLEDs Employing BODIPY‐Based Hybridized Local and Charge‐Transfer Emitter
Authors: Nie Xuewei , Mahmood Zafar , Liu Denghui , Li Mengke , Hu Dehua , Chen Wencheng , Xing Longjiang , Su Shijian , Huo Yanping , Ji Shaomin 
Published: February 2023

Hyperfluorescent organic light‐emitting diodes (HF‐OLEDs) approach has made it possible to achieve excellent device performance and color purity with low roll‐off using noble‐metal‐free pure organic emitter. Despite significant progress, the performance of HF‐OLEDs is still unsatisfactory due to the existence of a competitive dexter energy transfer (DET) pathway. In this contribution, two boron dipyrromethene (BODIPY)‐based donor‐acceptor emitters (BDP‐C‐Cz and BDP‐N‐Cz) with hybridized local and charge transfer characteristics (HLCT) are introduced in the HF‐OLED to suppress the exciton loss by dexter mechanism, and a breakthrough performance with low‐efficiency roll‐off (0.3%) even at high brightness (1000 cd m−2) is achieved. It is demonstrated that the energy loss via the DET channel can be suppressed in HF‐OLEDs utilizing the HLCT emitter, as the excitons from the dark triplet state of such emitters are funneled to its emissive singlet state following the hot‐exciton mechanism. The developed HF‐OLED device has realized a good maximum external quantum efficiency (EQE) of 19.25% at brightness of 1000 cd m−2 and maximum luminance over 60 000 cd m−2, with an emission peak at 602 nm and Commission International de L'Eclairage (CIE) coordinates (0.57, 0.41), which is among the best‐achieved results in solution‐processed HF‐OLEDs. This work presents a viable methodology to suppress energy loss and achieve high performance in the HF‐OLEDs.
Reframing governance possibilities for urban biodiversity conservation through systemic co‐inquiry
Authors: Mumaw Laura M. , Ison Ray , Corney Helen , Gaskell Nadine , Kelly Irene 
Published: February 2023

AbstractDespite decades of effort, biodiversity has not attracted effective political discourse, policies, or action to halt its decline. In cities in particular, biodiversity conservation is challenged by short‐term approaches, separately focusing on biodiversity or community well‐being rather than on their interconnection, and pervasive beliefs that urban citizenry lack the requisite ethic or skills for conservation action or biodiversity governance. We describe how a systemic co‐inquiry in Victoria Australia, conducted by citizen and agency practitioners alongside policy developers and academic researchers, modified understandings, practices, and institutional arrangements (governance) for urban biodiversity conservation. The most impactful outcomes of the early co‐inquiry period were (1) start‐up funding for a network to forge collaborations between community and local government actors that engage urban residents in supporting indigenous biodiversity in their gardens, and (2) empowered co‐inquiry members driving the network's development. These efforts have led to on‐going social learning and long‐term institutional arrangements for a burgeoning network of municipally based nature stewardship collaborations that are nurturing local human–nature relations. Key challenges include(d): maintaining the co‐inquiry, paradigms that undervalue urban biodiversity and the role of citizens, organizational inertia, and evaluation measures incommensurate with strengthening person‐nature relationships. Our research shows how systemic co‐inquiry involving citizen practitioners can surface misleading assumptions around biodiversity stewardship and governance, and help to empower citizen and agency actors to focus on nurturing sustainable human‐nature relations in cities.
Curcumin/cyclodextrin polymer inclusion complex attenuates ethanol‐induced liver injury by inhibition of DNA damage in mice
Authors: Chen Jianping , Fan Tugui , Li Jiarui , Li Rui , Liu Xiaofei , Wu Bing , Gao Jialong , Liu Ying , Dong Hao , Zhong Saiyi 
Published: February 2023

AbstractThis study was to examine the protective effects of curcumin/cyclodextrin polymer inclusion complex (CUR/CDP) on ethanol‐induced liver injury in mice and to explore its potential mechanisms. In the ethanol‐induced acute injury mouse model, the effects of pretreatment with silymarin, cyclodextrin polymer (CDP), curcumin (CUR) and CUR/CDP at low, middle, and high doses were evaluated by biochemical and histopathological examination. The liver index, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels in serum of the mice were measured. The superoxide dismutase (SOD), glutathione peroxidase (GSH‐PX) activities, and malondialdehyde (MDA) level in liver tissue were assessed by assay kits. Moreover, hematoxylin–eosin (HE) staining was carried out to observe pathological changes of liver. Western blotting was performed for determining the changes in the expressions of DNA damage‐associated proteins. The results showed that compared with the control group, the liver index and the levels of ALT, AST, LDH, and MDA in the ethanol treatment group were significantly increased and the activities of GSH‐Px and SOD were obviously decreased. However, pretreatment with silymarin, CUR, and CUR/CDP reversed the change of above indicators except CDP. Moreover, CUR/CDP at high dose further weakened the liver index, inhibited the biochemical indexes, and enhanced the activities of antioxidant enzymes to a greater extent than silymarin and CUR. Western blot analysis indicated that CUR/CDP significantly down‐regulated the expressions of DNA damage‐related proteins including p‐ATM, γ‐H2AX, p‐p53, and p‐p38MAPK, which inhibited ethanol‐induced the G2/M arrest and ultimately prevented liver function from oxidative stress injury. These results indicated that CUR/CDP possessed good protective effect on mice liver damage in vivo by increasing the activities of GSH‐Px and SOD to suppress DNA damage.
Genesis of greenockite (CdS) and associated sulphide‐gold mineralization from Mahakoshal belt, Central Indian Tectonic Zone
Authors: Baswani Srinivas Rao , Hazarika Pranjit , Meshram Tushar , Bage Gladson , Dora Muduru Lachhana , Saha Asit , Korakoppa Mahesh , Meshram Rajkumar , Chandramouleeswara Rao Kattoju 
Published: February 2023

The Zn‐Cd‐S critical minerals system is a significant mineralogical indicator of hydrothermal ore‐forming processes. The understanding of greenockite (CdS) formation in natural mineral systems is very restricted due to low crustal abundances (Cd <0.2 ppm). We report the first occurrence of greenockite from the Bagada orogenic gold prospect, Paleoproterozoic Mahakoshal belt, Central Indian Tectonic Zone (CITZ). This provides an ideal opportunity to access the occurrence and its genesis. Greenockite occurs in discrete sheared quartz veins hosted in phyllites. Sulphide mineralization is closely associated with hydrothermal chlorite alterations. Pyrrhotite, arsenopyrite, pyrite, and chalcopyrite assemblages are formed at high temperatures, while sphalerite and galena precipitated when the temperature decreased. Greenockite, native silver and bismuth with gold precipitated during the breakdown of arsenopyrite to scorodite in progressively oxidizing conditions. Greenockite precipitation occurred in a transforming hydrothermal environment from a reducing to an oxidizing one during late‐stage hydrothermal alteration. Sphalerite and chlorite thermometry yielded temperatures in the range from 266 to 366°C for this late‐stage hydrothermal alteration. Textural relations show two modes of occurrence of greenockite, one (Gck‐1) as exsolution within sphalerite (Sp‐2) and the other (Gck‐2) occurring as a discontinuous rim replacing the Cd‐rich sphalerite (Sp‐3). The Gck‐1 contains high Zn and low Cd, while as compared to Gck‐2. Zinc and Cd in greenockite show diadochy relation (Zn2+ ↔ Cd2+). Laser ablation ICPMS analyses of sphalerite (Sp‐2) reveal remarkably high Cd contents (1.9–12 wt%). Cd >0.02 ppm suggests possible Cd derivation from sphalerite (Sp‐2) under variable fS2, T, pH, fO2 conditions, fluid–rock interaction, and change in the Zn/Cd ratio. Sphalerite compositions display a low Zn/Cd (av.22) ratio and high temperature of formation, with characteristics intermediate between volcanogenic massive sulphides (VMS) and magmatic‐hydrothermal Cu‐Pb‐Zn system.
Uterine tamponade in postpartum hemorrhage with handmade balloons: Comparison of manufacturing, infusion, and total times
Authors: Alves Álvaro Luiz Lage , da Silva Jane Braga , de Oliveira Santos Mayra , Lopes Andrezza Vilaça Belo , Silva Roberta Bessa Veloso , Senra Janaína Campos 
Published: February 2023

AbstractObjectiveTo compare the manufacturing, infusion, and total times of handmade balloons for uterine tamponade using the El Hennawy and Alves techniques, given the failure of initial measures and uterotonic therapy to control postpartum hemorrhage.MethodsAn open clinical trial (clinical article) was conducted among 30 physicians, residents, and assistants in an Obstetrics Department. Each participant manufactured and infused one of two different balloons compared in the study, in a randomly predefined sequence. The manufacturing and infusion times were timed by the researchers and their medians were compared using the t test or Mann–Whitney U test.ResultsThe manufacturing time of the El Hennawy balloon was 72 s lower in relation to the Alves balloon (P < 0.010). Regarding the infusion time, the Alves balloon was filled faster than the El Hennawy balloon (P < 0.010). The total time (manufacturing and infusion) of Alves balloon was also lower than the El Hennawy device (P < 0.010).ConclusionsAlthough the El Hennawy balloon was manufactured more quickly, the total time of manufacturing and infusing the Alves balloon was much faster, which makes it the most suitable device to be used in critical situations of postpartum hemorrhage.
Identifying symptom clusters among pregnant women during early and late pregnancy
Authors: Zhang Yunxue , Xu Xiaofang , Xie Zihui , Li Yuanyuan , Zhao Di , Lv Gaorong , Li Ping 
Published: February 2023

AbstractObjectivesTo investigate the status of multiple psychosomatic symptoms among women and identify symptom clusters at different gestational stages.MethodsThis was a cross‐sectional study and a consecutive sample of 557 pregnant women were recruited. They were asked to complete the Memorial Symptom Assessment Scale, and to supply sociodemographic and clinical information. Spearman correlation analysis, partial correlation networks, and hierarchical cluster analysis were carried out to identify the optimal number of symptom clusters.ResultsThe top five scores for symptoms in early pregnancy were nausea, lack of appetite, feeling drowsy, lack of energy, and vomiting. Weight gain, difficulty sleeping, sweating, lack of energy, and dry mouth scored high in late pregnancy. Four clusters were identified in early pregnancy, and three clusters were determined in late pregnancy.ConclusionsWomen experience multiple psychosomatic symptoms during pregnancy, and the manifestation of symptoms varies at different stages. The present study has provided new insights into symptom clusters in pregnant women.
C‐reactive protein/albumin ratio and IL‐6 are associated with disease activity in patients with ulcerative colitis
Authors: Feng Wan , Zhu Lei , Liu Yajun , Xu Luzhou , Shen Hong 
Published: February 2023

AbstractBackgroundCytokines are key mediators of the inflammation in ulcerative colitis (UC); there are inconsistent data on cytokines profile in patients with UC. C‐reactive protein/albumin ratio (CRP/ALB) has also been found as an inflammatory indicator. However, the role of CRP/ALB in UC remains unclear. We aimed to evaluate the CRP/ALB ratio and cytokines profile in patients with UC. We further explore the association between CRP/ALB and inflammatory markers, such as erythrocyte sedimentation rate (ESR), fecal calprotectin (FC) and cytokines.MethodsOne hundred thirty UC patients and 65 controls were included in the study. Clinical and laboratory findings were retrospectively reviewed; differences in variables between two groups were examined using the Mann–Whitney U‐test. The association between CRP/ALB, cytokines, and clinical parameters was determined by Spearman's correlation test.ResultsCRP/ALB levels were significantly elevated in active UC patients. The optimal cutoff level of the CRP/ALB was 0.083. The patients with active UC had a median interleukin‐6 (IL‐6) level of 7.715 pg/ml (interquartile ranges, IQR 3.475–14.63), which was significantly higher than those in remission (2.95 pg/ml, IQR 2.17–5.44) (p < 0.001). Positive correlations between CRP/ALB and inflammatory markers were also observed.ConclusionsOur results suggest that CRP/ALB and IL‐6 could be potential biomarkers for assessment of clinical activity in Chinese patients with UC.
The sensitivity and specificity of COVID‐19 rapid anti‐gene test in comparison to RT‐PCR test as a gold standard test
Authors: Al‐Hashimi Oday Taher Mohammed , AL‐Ansari Waleed Ibraheem Ali , Abbas Safia Abdullkareem , Jumaa Dalal Saad , Hammad Shams Ahmed , Hammoudi Faten Abdulghani , Allawi Ali Abdulmajid dyab 
Published: February 2023

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) is a modern infectious disease, first identified in December 2019 in Wuhan, China. The etiology is via severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), in a pandemic manner. The study aimed to compare between RT‐PCR and rapid anti‐gene tests for COVID‐19 with regard to sensitivity and specificity.MethodsThis is a cohort hospital‐based study done during the period of July to September 2020. Both rapid anti‐gene test kit (SARS‐CoV‐2) and RT‐qPCR were used for the detection of COVID‐19 in suspected cases.ResultsA total of 148 cases were tested using both the RT‐qPCR and rapid test. Twenty‐nine (19.6%) of these cases had positive results for RT‐qPCR and 119 (80.4%) were negative, whereas 52 (35.1%) patients were positive to rapid anti‐gene test and 96 (64.9%) of them negative. The sensitivity of the rapid test was 37.9%, the specificity was 65.5% and the accuracy was 64.44%. Rapid IgG test was positive in 47 (31.8) of cases. Although, rapid IgM test was positive in 18 (12.2%). The rapid IgG test was more sensitive than rapid IgM (Sensitivity 34.48% vs. 3.45%), but it was less specific than rapid IgM test (Specificity 68.91% vs. 85.71%).ConclusionWe cannot consider rapid anti‐gene test alone as a diagnostic method for COVID‐19. We should also conduct RT‐PCR test and other investigations like imaging CT scan of chest to confirm the diagnosis. The rapid IgG test is more sensitive than rapid IgM, but it was less specific.
Glypican‐4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling
Authors: Maddala Rupalatha , Eldawy Camelia , Bachman William , Soderblom Erik J. , Rao Ponugoti V. 
Published: February 2023

AbstractA common adverse response to the clinical use of glucocorticoids (GCs) is elevated intraocular pressure (IOP) which is a major risk factor for glaucoma. Elevated IOP arises due to impaired outflow of aqueous humor (AH) through the trabecular meshwork (TM). Although GC‐induced changes in actin cytoskeletal dynamics, contractile characteristics, and cell adhesive interactions of TM cells are believed to influence AH outflow and IOP, the molecular mechanisms mediating changes in these cellular characteristics are poorly understood. Our studies focused on evaluating changes in the cytoskeletal and cytoskeletal‐associated protein (cytoskeletome) profile of human TM cells treated with dexamethasone (Dex) using label‐free mass spectrometric quantification, identified elevated levels of specific proteins known to regulate actin stress fiber formation, contraction, actin networks crosslinking, cell adhesion, and Wnt signaling, including LIMCH1, ArgBP2, CNN3, ITGBL1, CTGF, palladin, FAT1, DIAPH2, EPHA4, SIPA1L1, and GPC4. Several of these proteins colocalized with the actin cytoskeleton and underwent alterations in distribution profile in TM cells treated with Dex, and an inhibitor of Abl/Src kinases. Wnt/Planar Cell Polarity (PCP) signaling agonists‐Wnt5a and 5b were detected prominently in the cytoskeletome fraction of TM cells, and studies using siRNA to suppress expression of glypican‐4 (GPC4), a known modulator of the Wnt/PCP pathway revealed that GPC4 deficiency impairs Dex induced actin stress fiber formation, and activation of c‐Jun N‐terminal Kinase (JNK) and Rho kinase. Additionally, while Dex augmented, GPC4 deficiency suppressed the formation of actin stress fibers in TM cells in the presence of Dex and Wnt5a. Taken together, these results identify the GPC4‐dependent Wnt/PCP signaling pathway as one of the crucial upstream regulators of Dex induced actin cytoskeletal reorganization and cell adhesion in TM cells, opening an opportunity to target the GPC4/Wnt/PCP pathway for treatment of ocular hypertension in glaucoma.
Associations between the Trauma Memory Quality Questionnaire and posttraumatic stress symptoms in youth: A systematic review and meta‐analysis
Authors: Reed Joanna , Taylor Jasmine , Randall Grace , Burgess Aaron , Meiser‐Stedman Richard 
Published: February 2023

AbstractCognitive models of posttraumatic stress disorder (PTSD) propose that trauma memory characteristics are implicated in the etiology of the disorder. Empirical support for cognitive models in youth is necessary to ensure psychological interventions are based on appropriate theory. This meta‐analysis was conducted to quantitatively investigate the strength of the associations between self‐reported trauma memory characteristics (e.g., sensory and temporal features), measured using the Trauma Memory Quality Questionnaire (TMQQ), and posttraumatic stress symptoms (PTSS) in children and adolescents. PsycINFO, MEDLINE, CINAHL, PTSDPubs, and ProQuest Dissertations and Theses Global were searched for relevant literature. In total, 11 studies (N = 1,270 participants) met the inclusion criteria for the random‐effects meta‐analysis. A large effect size was observed for the association between trauma memory characteristics and PTSS, r = .51, 95% CI [.44, .58], and was maintained in subgroup analyses of the prospective association between trauma memory characteristics and later PTSS (k = 5, n = 6 28), r = .51, 95% CI [.42, .59]. A slightly larger effect size was observed in subgroup analyses of the cross‐sectional association between trauma memory characteristics and concurrent PTSS (k = 11, N = 1,270), r = .62, 95% CI [.53, .70]. Sensitivity analyses on study quality, TMQQ alteration, chronic trauma exposure, geographical location, and PTSS measure supported the robustness of these results. These findings provide empirical support for the role of trauma memory characteristics in PTSS, congruent with cognitive models, suggesting this theoretical framework is appropriate for youth populations. Limitations and recommendations for future research are discussed.
Winter mulching practice alters soil bacterial communities and networks in lei bamboo (Phyllostachys praecox) forests
Authors: Wu Fei , Wu Na , Zhang Linping , Li Zuyao , Pei Nancai , Jin Cangfu , Huang Yuxuan 
Published: February 2023

AbstractWinter mulching is widely used to raise soil temperature and promote earlier harvesting in agroforestry, but successive years of mulching can lead to soil degradation. The effect of winter mulch on soil bacterial community composition and co‐occurrence patterns is not clear. The influence of different mulches (a defatted seed cake of Camellia oleifera, DS; a mixture of wheat straw and chicken manure, MWC; and wheat straw, WS) on soil bacterial communities and networks in lei bamboo (Phyllostachys praecox) forests over a four‐month mulching period was studied using Illumina sequencing of the 16S rRNA gene. The results showed that mulching time and mulching material treatment significantly influenced bacterial community composition and diversity, mainly driven by nutrient availability. MWC and WS mulching treatments decreased α‐diversity of the bacterial communities, whereas the DS treatment had no significant impact. The oligotrophs, Gryllotalpicola, Granulicella, and Verrucomicrobia, were enriched before and at the end of mulching, while the copiotrophs, Deltaproteobacteria, were enriched in the middle of the mulching period (Jan). Comparing the three mulching treatments, Proteobacteria were enriched in DS mulching soils in Jan. The complexity of the four networks decreased with pre‐mulching, DS mulching, WS mulching, and MWC mulching networks, with a reduction in the number of edges and average degree observed. The results suggested that winter mulching practices adversely affected soil bacterial community diversity and interactions, which may be detrimental to the resistance of bacterial communities to environmental changes and soil sustainability. Mulching MWC and WS has a greater risk of loss of soil bacterial biodiversity than DS.
Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery
Authors: Toropitsyn Evgeniy , Ščigalková Ivana , Pravda Martin , Velebný Vladimír 
Published: February 2023

AbstractOsteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation of cartilage and synovial fluid (SF). Platelet derivatives as platelet‐rich plasma (PRP) and platelet lysate have great potential in the treatment of osteoarthritis because they contain biologically active substances including growth factors (GFs). Rapid release of GFs and their short biological half‐life are factors that can limit the therapeutic impact of PRP therapy. Herein, the first work that describes hydrogels based on polyaldehyde derivative of hyaluronic acid (HA‐OX) as carriers of platelet derivatives for in situ applications is presented, which can be a possible solution to the problem. HA‐OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(<10 Pa s) and injection force (<20 N), and reach elastic modulus up to 2000 Pa. Insulin‐like GF‐1 and Platelet‐derived GF‐AB release from HA‐OX hydrogels (mesh size 297–406 nm) by Fickian and non‐Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%–92%). Based on the obtained results, the unique concept of a new material that can restore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed.