bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intellectual Property Based Financing: Juridical Review of Government Regulation Number 24 of 2022 And Relevance of Establishing Intellectual Property Rights Appraisal Institution
Authors: Sulistianingsih Dewi , Al Fikry Ahmad Habib , Setiawan Andry 
Published: September 2023

The issuance of Government Regulation Number 24 of 2022 is the hope for achieving an advanced national economy through the utilization of intellectual property rights as collateral objects in bank and non bank financial institutions. However, this is faced with the absence of an intellectual property rights appraisal institution in Indonesia. This paper aims to: (i) explain intellectual property-based financing arrangements based on Government Regulation Number 24 of 2022; and (ii) describes the establishment of an intellectual property rights appraisal institution in Indonesia. The author uses a normative juridical research method with a statutory and comparative approach. The results of the writing show that: 9i) Government Regulation Number 24 of 2022 regulates intellectual property-based financing schemes through bank and non-bank financial institutions; and (ii) the discourse on establishing an institution to assess intellectual property rights in Indonesia trough laws and regulations. This independent institution functions to set standards for valuing intellectual property rights and valuing intellectual property rights to be used as collateral for financing trough bank and non-bank financial institutions.
Judicial Transformation: Integration of AI Judges in Innovating Indonesia's Criminal Justice System
Authors: Putra Panca Sarjana , Fernando Zico Junius , Nunna Bhanu Prakash , Anggriawan Rizaldy 
Published: September 2023

In the midst of the current digital era, artificial intelligence (AI) technology offers the potential to improve many aspects of life, including in the field of justice. In this context, the idea of integrating AI into the judicial system emerges as one potential solution. AI judges, as a concept, are considered capable of providing more objective decisions, speeding up court proceedings, and reducing the workload of human judges. The purpose of this study is to evaluate the potential and challenges in the integration of artificial intelligence (AI) into the Indonesian judicial system, with the ultimate goal of creating a judicial system that is more fair, efficient, and in accordance with Indonesia's socio-cultural context. This research utilizes normative legal methods by adopting statutory, conceptual, comparative, and futuristic approaches. The nature of this research is descriptive-prescriptive. The data that has been collected is analyzed using the content analysis method. The result of this research is that "AI Judges" has the potential to be a very useful tool in Indonesia's criminal justice system in the future. However, the integration of AI must be done carefully, taking into account all the benefits and risks, and ensuring that justice and humanity remain at the core of the system. In addition, inter-sectoral cooperation and a deep understanding of the local context are key to the success of this integration. In an overall perspective, while AI technology promises greater efficiency and objectivity in the justice system, the essence of humanity and cultural considerations remain irreplaceable aspects. Thus, it is hoped that in the future, collaboration between AI judges and human judges can create a justice system that is more fair, efficient, and in accordance with Indonesia's socio-cultural context.Keywords: Judicial Transformation, AI Intergration, AI Judges, Criminal Justice Reform
Analysis of the Relationship Between E-Learning Service Quality and Student Trust, Student Satisfaction, and Student Loyalty
Authors: Atmaja Dodi Ria , Sagala Heldina Marta br 
Published: September 2023

The research was conducted to explore the impact of service quality on student loyalty with student satisfaction and student trust as mediation. This sorting is expected to contribute to the university in adding information and positive managerial implications to its management. This research aims to demonstrate that the quality of services on e-learning in affecting several other factors is also able to increase student loyalty. The research population was 95 respondents active students at Esa Unggul University. The questionnaire data collection took place online in February 2023. The method used for data analysis is partial least squares structural equation structure equation modeling. The results show that there is a positive impact of service quality, student satisfaction, and student trust. There is also a role of student satisfaction mediation, and student trust. The research is expected to contribute to educational institutions in improving the quality role of e-learning services aimed at increasing student loyalty to universities.
Simulation of the process of formation of the schoolchildrenʼs health care competence based of interactive physical education
Authors: Afanasiev A.V. 
Published: September 2023

The article reveals the essence and content of the concept of "health-preserving competence", outlines the need and substantiates the main approaches to its formation as a key competence in the process of physical education of schoolchildren in the context of the views of the New Ukrainian School. It was determined that the coronavirus pandemic, quarantine restrictions, and the full-scale Russian invasion significantly worsened physical and mental health, limited the motor activity of schoolchildren, increased the level of stress, and provoked the activation of psychosomatic diseases in children and young people, which justifies the formation of health care competence of schoolchildren as an important strategic tasks of the state.
The possibilities of using interactive didactic methods in the process of teaching physical culture of students in the conditions of the competence approach and partnership pedagogy are shown. A model of the process of formation of health-preserving competence of schoolchildren based on interactive training of physical culture is presented, which makes it possible to reproduce the dynamics of the educational process and predict its development. The components of the educational process, the content, means, methods and forms of organization of physical education with the aim of forming the health-preserving competence of schoolchildren, the criteria for evaluating the expected result - the formation of this competence: motivational-value, cognitive, activity and behavioral have been determined. The indicators of the formation of health care competence are described.
Experimental verification of the effectiveness of the pedagogical model of the formation of natural and scientific competence of future specialists in physical therapy and ergotherapy
Authors: Fastivets Anna 
Published: September 2023

The article presents the course and results of a formative experiment to test the effectiveness of a theoretically substantiated pedagogical model of forming the natural and scientific competence of future specialists in physical therapy and ergotherapy. The content, technologies, and mechanisms of the organization of the experimental study of natural and scientific training of future specialists are substantiated, an analysis of the effectiveness of the developed methodics at the relevant stages of natural and scientific training is conducted. The dynamics of quantitative and qualitative indicators of the formation of natural and scientific competence of future specialists in physical therapy and ergotherapy is analyzed on professional and orientative, fundamental professional and specialized professional stages of training. The concept of «competence of a physical therapist, ergotherapist», certified with a document on professional education, includes: competence in the field of theory in physical therapy and ergotherapy; competence in the field of modern rehabilitation technologies and methodics; competence in designing and rehabilitation systems; competence in professional interaction with participants of the rehabilitation process (members of the multidisciplinary team, patients, family members / caregivers of patients); competence in the field of theory and practice of research in the fields of physical therapy and ergotherapy; competence in medical innovations; competence in organization and management; competence in professional self-improvement.
The effectiveness of the proposed model is verified through a system of criteria (personal and motivational, cognitive, integrative and substantial, informational and communicative, operational and activity orientated, health-keeping, and professional and reflexive); for each criterion, a number of indicators and levels (elementary, basic, sufficient and creative) of the formation of natural and scientific competence of future specialists are distinguished. Using statistical methods, the reliability of the obtained results and the correctness of the formulated hypothesis are confirmed.
Boas práticas em ventosaterapia: revisão narrativa
Authors: Martins Eliane Cristina , Amante Lúcia Nazareth , Chiodelli Salum Nádia , Martins Giovana da Silva , Dacorégio Bianca Martins 
Published: September 2023

Objetivo: Identificar os estudos que descrevam os procedimentos, técnica e fundamentação da Ventosaterapia para sinalização de estado da arte e boas práticas. Métodos: Revisão narrativa, delineada em seis fases: escolha do tema, busca na literatura, seleção de fontes, leitura transversal, redação e referências. Resultados: A busca resultou em 401 artigos, destes foram criteriosamente selecionados cinco estudos. Os principais achados incluem: estudo que fornece evidências quanto aos efeitos das pressões e tempo de duração da ventosaterapia na resposta ao fluxo sanguíneo de pele, além disso, a identificação de possíveis mecanismos de ventosaterapia baseados em teorias que explicam seus diversos efeitos; outro estudo elaborou um check list, enquanto modelo de qualidade, na execução da técnica em lide; e outro sinalizou redução da pressão arterial com uso da ventosaterapia com sangria. Conclusão: Os estudos destacados forneceram evidências sobre a eficácia da ventosaterapia no tratamento de certas indicações clínicas. Com efeito, considera-se que a ventosaterapia é um método tradicional, e atualmente vem sendo bastante indicada adjunta ao tratamento convencional, para uma gama de patologias bem como na homeostasia do corpo e da mente.
Pre-clinical investigation of liquid sirolimus for local drug delivery
Authors: Todd Meagan , Liu Linda B. , Saul Justin M. , Yazdani Saami K. 
Published: September 2023

IntroductionSirolimus is currently being explored as an alternative drug to paclitaxel for the treatment of peripheral artery disease (PAD). To date, sirolimus has only been used as drug coatings for stents and balloons and no studies have yet demonstrated the delivery of sirolimus in liquid form. The purpose of this pilot study was to investigate the feasibility of the delivery of liquid sirolimus into arterial segments in a benchtop peripheral artery bioreactor.MethodsThe feasibility to deliver liquid therapy was first tested on four drug delivery devices using a fluorescently tagged liquid drug and an ex vivo porcine artery benchtop model. The four devices included the Bullfrog micro-infusion device, ClearWay RX catheter, Occlusion perfusion catheter (OPC), and the targeted adjustable pharmaceutical administration system (TAPAS). Penetration of the fluorescently tagged drug was measured via microscopic imaging and quantification of the depth of drug penetration into all device-treated tissue. Based on the penetration outcome, we then selected a single device to deliver liquid sirolimus into the ex vivo porcine artery model undergoing physiological flow and pressure conditions. The liquid sirolimus-treated arteries were collected from the ex vivo bioreactor at 1- and 24-hour post-delivery and arterial drug retention analyzed by liquid chromatography-tandem mass spectrometry.ResultsFluorescent microscopy demonstrated that drug delivery with the OPC had greater drug penetration into the medial wall as compared to other devices (OPC: 234 ± 161 µm; TAPAS: 127 ± 68 µm; ClearWay: 118 ± 77 µm; Bullfrog: 2.12 ± 3.78 µm; p = 0.098). The results of the ex vivo flow-circuit bench top model showed that the OPC device successfully delivered the liquid sirolimus at 1-hour (5.17 ± 4.48 ng/mg) and 24-hour (0.78 ± 0.55 ng/mg).ConclusionsThese results demonstrate for the first time the ability to deliver liquid sirolimus directly to the medial layer of an artery via a liquid delivery catheter.
Temporal change in eruption style during the basaltic explosive An’ei eruption of the Izu-Oshima volcano, Japan: insights from stratigraphy and chemical composition analyses
Authors: Ikenaga Yuya , Maeno Fukashi , Yasuda Atsushi 
Published: September 2023

Basaltic eruptions sometimes show an explosive and complex nature; thus, clarifying the sequence and controlling parameters is essential for understanding their causes. The An’ei eruption of the Izu-Oshima volcano during 1777–1792 was a complex basaltic eruption producing lava flows, pyroclastic falls, and ash plumes. We reconstructed the transition of the eruption style based on geological data combined with comparisons with data from historical documents and used chemical analyses to develop a magma plumbing model. The An’ei eruption started in August 1777 with scoria ejection. The scoria deposit was classified into Units A–C. Unit A scoria was produced by early weak explosions and more intense subsequent explosions. Unit B scoria marked a return to weak plumes before the summit eruption reached its climactic phase in November 1778 and explosively ejected Unit C scoria. Several lava flows were also effused from the foot of the scoria cone during these periods of scoria ejection. After a 5-year hiatus, the eruption ultimately shifted to persistent, weak ash ejection and pyroclastic surges. The tephra volumes of Units A, B, and C were estimated at 1.9–4.3 × 107, 0.6–4.5 × 106, and 1.3–3.2 × 107 m3, respectively. Associated column heights of 8–11, 3–10, and 9–12 km were obtained for Units A, B, and C, respectively, resulting in sub-Plinian classification. Chemical analyses have shown that the plagioclase phenocryst content increased as the eruption progressed. The transition from relatively weak activity with Strombolian and sub-Plinian explosions, caused by aphyric magma, to short-period activity with more intense sub-Plinian explosions, caused by porphyritic magma, can be explained by evacuation of magma from multiple reservoirs with different contents of plagioclase phenocrysts. Simultaneous lava flows that have different petrological features from those of the scoria eruptions also suggest multiple magma reservoirs and pathways. This view of the temporal change in eruptive style, corresponding to change in magma type, is essential for understanding the eruptive processes of large-scale basaltic eruptions of the Izu-Oshima volcano and contributes to clarifying the nature and hazards of basaltic eruptions which turn into explosive activities in general.
Metabolite profiles and DNA methylation in metabolic syndrome: a two-sample, bidirectional Mendelian randomization
Authors: Jones Alana C. , Ament Zsuzsanna , Patki Amit , Chaudhary Ninad S. , Srinivasasainagendra Vinodh , Kijpaisalratana Naruchorn , Absher Devin M. , Tiwari Hemant K. , Arnett Donna K. , Kimberly W. Taylor , Irvin Marguerite R. 
Published: September 2023

Introduction: Metabolic syndrome (MetS) increases the risk of cardiovascular disease and death. Previous ‘-omics’ studies have identified dysregulated serum metabolites and aberrant DNA methylation in the setting of MetS. However, the relationship between the metabolome and epigenome have not been elucidated. In this study, we identified serum metabolites associated with MetS and DNA methylation, and we conducted bidirectional Mendelian randomization (MR) to assess causal relationships between metabolites and methylation.Methods: We leveraged metabolomic and genomic data from a national United States cohort of older adults (REGARDS), as well as metabolomic, epigenomic, and genomic data from a family-based study of hypertension (HyperGEN). We conducted metabolite profiling for MetS in REGARDS using weighted logistic regression models and validated them in HyperGEN. Validated metabolites were selected for methylation studies which fit linear mixed models between metabolites and six CpG sites previously linked to MetS. Statistically significant metabolite-CpG pairs were selected for two-sample, bidirectional MR.Results: Forward MR indicated that glucose and serine metabolites were causal on CpG methylation near CPT1A [B(SE): −0.003 (0.002), p = 0.028 and B(SE): 0.029 (0.011), p = 0.030, respectively] and that serine metabolites were causal on ABCG1 [B(SE): −0.008(0.003), p = 0.006] and SREBF1 [B(SE): −0.009(0.004), p = 0.018] methylation, which suggested a protective effect of serine. Reverse MR showed a bidirectional relationship between cg06500161 (ABCG1) and serine [B(SE): −1.534 (0.668), p = 0.023].Discussion: The metabolome may contribute to the relationship between MetS and epigenetic modifications.
Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
Authors: Nguyen Nhu T. Q. , Doan Thien N. M. , Sato Kei , Tkaczyk Christine , Sellman Bret R. , Diep Binh An 
Published: September 2023

BackgroundPatients with septic shock caused by Staphylococcus aureus have mortality rates exceeding 50%, despite appropriate antibiotic therapy. Our objectives were to establish a rabbit model of S. aureus septic shock and to determine whether a novel immunotherapy can prevent or halt its natural disease progression.MethodsAnesthetized rabbits were ventilated with lung-protective low-tidal volume, instrumented for advanced hemodynamic monitoring, and characterized for longitudinal changes in acute myocardial dysfunction by echocardiography and sepsis-associated biomarkers after S. aureus intravenous challenge. To demonstrate the potential utility of this hyperdynamic septic shock model for preclinical drug development, rabbits were randomized for prophylaxis with anti-Hla/Luk/ClfA monoclonal antibody combination that neutralizes alpha-hemolysin (Hla), the bicomponent pore-forming leukocidins (Luk) including Panton-Valentine leukocidin, leukocidin ED, and gamma-hemolysin, and clumping factor A (ClfA), or an irrelevant isotype-matched control IgG (c-IgG), and then challenged with S. aureus.ResultsRabbits challenged with S. aureus, but not those with saline, developed a hyperdynamic state of septic shock characterized by elevated cardiac output (CO), increased stroke volume (SV) and reduced systemic vascular resistance (SVR), which was followed by a lethal hypodynamic state characterized by rapid decline in mean arterial pressure (MAP), increased central venous pressure, reduced CO, reduced SV, elevated SVR, and reduced left-ventricular ejection fraction, thereby reproducing the hallmark clinical features of human staphylococcal septic shock. In this model, rabbits pretreated with anti-Hla/Luk/ClfA mAb combination had 69% reduction in mortality when compared to those pretreated with c-IgG (P&lt;0.001). USA300-induced acute circulatory failure—defined as &gt;70% decreased in MAP from pre-infection baseline—occurred in only 20% (2/10) of rabbits pretreated with anti-Hla/Luk/ClfA mAb combination compared to 100% (9/9) of those pretreated with c-IgG. Prophylaxis with anti-Hla/Luk/ClfA mAb combination halted progression to lethal hypodynamic shock, as evidenced by significant protection against the development of hyperlactatemia, hypocapnia, hyperkalemia, leukopenia, neutropenia, monocytopenia, lymphopenia, as well as biomarkers associated with acute myocardial injury.ConclusionThese results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting S. aureus virulence factors for the prevention of staphylococcal septic shock.
A milder form of molybdenum cofactor deficiency type A presenting as Leigh's syndrome-like phenotype highlighting the secondary mitochondrial dysfunction: a case report
Authors: Almudhry Montaha , Prasad Asuri N. , Rupar C. Anthony , Tay Keng Yeow , Ratko Suzanne , Jenkins Mary E. , Prasad Chitra 
Published: September 2023

BackgroundMolybdenum cofactor deficiency (MoCD) (OMIM# 252150) is an autosomal-recessive disorder caused by mutations in four genes involved in the molybdenum cofactor (MOCO) biosynthesis pathway.ObjectivesWe report a milder phenotype in a patient with MOCS1 gene mutation who presented with a Leigh-like presentation.Case reportWe present the case of a 10-year-old boy who was symptomatic at the age of 5 months with sudden onset of dyskinesia, nystagmus, and extrapyramidal signs following a febrile illness. Initial biochemical, radiological, and histopathological findings a Leigh syndrome-like phenotype; however, whole-exome sequencing detected compound heterozygous mutations in MOCS1 gene, c.1133 G&gt;C and c.217C&gt;T, confirming an underlying MoCD. This was biochemically supported by low uric acid level of 80 (110–282 mmol/L) and low cystine level of 0 (3–49), and a urine S-sulfocysteine at 116 (0–15) mmol/mol creatinine. The patient was administered methionine- and cystine-free formulas. The patient has remained stable, with residual intellectual, speech, and motor sequelae.ConclusionThis presentation expands the phenotypic variability of late-onset MoCD A and highlights the role of secondary mitochondrial dysfunction in its pathogenesis.
Nontraumatic subdural hematoma in patients on hemodialysis with end-stage kidney disease: a systematic review and pooled analysis
Authors: Yang Liling , Li Zongping , Dai Xiaoyu , Wang Lijun , Wang Xiaoyi , Liu Hongyuan 
Published: September 2023

BackgroundThe original treatment may aggravate when hemodialysis (HD) patients have nontraumatic subdural hematoma (NSDH). End-stage kidney disease patients are at increased risk for NSDH, but its risk factors and outcomes are not sufficiently explored at present.MethodsElectronic databases, including PubMed, EMBASE, and Web of Science were searched by using various combinations of the keywords “Hemodialysis,” “Renal Insufficiency,” “Extracorporeal Dialysis,” “Subdural Hematoma,” “Subdural Hemorrhage,” “Subdural Hematomas,” and “Subdural Hemorrhages” in accordance with the PRISMA guidelines. Sixteen papers were selected. Relevant patient data were extracted, aggregated, and analyzed.ResultsA total of 74 patients were analyzed, including 37 male, 26 female, and 11 with no gender data, with a mean age of 56 years (range, 16–81 years). There were 43 patients with hypertension, 36 patients with diabetes, 16 patients who used oral anticoagulants before dialysis, and 10 patients with atrial fibrillation. The diagnosis of subdural hematoma (SDH) was made by computed tomography (CT) (n = 51), carotid arteriography (n = 7), surgical exploration (n = 3), and autopsy (n = 2). Forty cases underwent surgical treatment, including craniotomy and burr hole (or twist drill) drainage. The 1 year mortality rate of NSDH was 45.9%. The mortality rate after conservative treatment (61.8%) was higher than that after surgical intervention (32.5%). The mortality rate of NSDH in dialysis patients with atrial fibrillation and in those who used oral anticoagulants before hemodialysis (HD) was 90 and 81%, respectively.ConclusionNSDH is rare in HD, and mortality is high if NSDH occurs in dialysis patients. Surgical intervention reduces the mortality from NSDH in patients on HD (p &lt; 0.02). Patients with atrial fibrillation and those who were taking oral anticoagulants before dialysis have a higher NSDH mortality (p &lt; 0.01).