bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of the North Anatolian Fault from a diffuse to a localized shear zone in the North Aegean Sea during the Plio-Pleistocene
Authors: Rodriguez M , Sakellariou D , Gorini C , Janin A , D'Acremont E , Pourhiet L Le , Chamot-Rooke N , Tsampouraki-Kraounaki K , Morfis I , Rousakis G , Henry P , Lurin A , Delescluse M , Briole P , Rigo A , Arsenikos S , Bulois C , Fernández-Blanco D , Beniest A , Grall C , Chanier F , Caroir F , Dessa J-X , Oregioni D , Nercessian A 
Published: September 2023

SUMMARY
The North Anatolian Fault is the ∼1200-km-long active continental transform boundary between Anatolia and Eurasia. This strike-slip system initiated around 10–12 Ma and experienced diachronous episodes of strain localization along its strike. The structural evolution of the ∼350-km-long fault segments crossing the North Aegean Sea remains to be accurately investigated. There, the modern North Anatolian Fault is localized along two main branches: the northern branch ends at the North Aegean Trough and the southern branch ends at the Edremit-Skyros Trough. The Evia Basin is located in the North Aegean Domain between the North Anatolian Fault and the Corinth Rift. This study presents seismic reflection lines crossing the aforementioned structures of the North Aegean Domain, which document their subsurface structure and the sedimentary record of their activity since the Messinian. The seismic-reflection data set is tied to regional-scale stratigraphic markers, which constrains the age of main tectonic events related to the formation of the North Anatolian Fault. The seismic-reflection lines show that the two main branches of the North Anatolian Fault became localized structures at 1.3–2 Ma, coevally with the formation of the Evia Basin. Since 2 Ma, the North Aegean Troughs developed as a series of horsetail basins propagating westwards at the termination of the branches of the North Anatolian Fault. On a regional scale, the wide and diffuse North Anatolian transtensive shear zone active from Serravalian to Late Pliocene turned into a narrower shear zone at the two main branches of the North Anatolian Fault since the Early Pleistocene. This abrupt episode of strain localization occurred in the frame of the major Early Pleistocene change in stress regime from NE–SW to N–S extension, which has been observed throughout the Aegean Sea.
High spatial resolution marine gravity trend determined from multisatellite altimeter data over Bay of Bengal
Authors: Zhu Fengshun , Liu Xin , Li Zhen , Yuan Jiajia , Guo Jinyun , Sun Heping 
Published: September 2023

SUMMARY
Mass redistribution in the Earth system induce variations of the Earth's gravity field. Now, the time-varying gravity models from the Gravity Recovery and Climate Experiment (GRACE) mission can only estimate the large-scale gravity changes, so the high-resolution marine gravity trend (MGT) model is urgently required to detect small-scale Earth's mass migration. The sea level change is a significant response to marine gravity field change. Here, we propose to estimate the high-resolution MGT using the sea level trend (SLT). Firstly, the SLT model caused by marine mass change (MMC) on 5′ × 5′ grids covering the Bay of Bengal (BOB) is established based on multisatellite altimetry data and EN4 quality-controlled ocean data, named BOB_MMC_SLT. Then, the marine mass trend (MMT) is calculated using the BOB_MMC_SLT. The spherical harmonic function (SHF) method is applied to estimate MGT using the MMT, and this MGT model on 5′ × 5′ grids, named BOB_SHF_MGT, is used to study marine gravity changes and their associated geophysical processes. The results show that, the MGT mean of BOB_SHF_MGT is about 0.14 μGal yr−1, which indicates that marine gravity in BOB is rising. The earthquakes mainly occur in the southeastern BOB where MGT is obviously rising, which may be related to the increased density of the Burma Plate due to the subduction of the India Plate and the Australia Plate. BOB_SHF_MGT shows that the marine gravity rise rate is increasing from the 85°E ridge to Andaman–Nicobar ridge, with a maximum at the location where the India Plate subducts to the Burma Plate. The MGT model based on altimetry data constructed by SHF method is important for the study of small-scale mass migration near the subduction boundaries.
Psychometric properties of the Health Literacy Knowledge and Experience Survey-2 for Turkish nursing students
Authors: Haney Meryem Öztürk , Yoğurtcu Huri 
Published: September 2023

Abstract
Nursing students should be able to assess the health literacy levels of patients and enable patients to understand important health information. No scale has been developed to measure the health literacy knowledge and experience of Turkish nursing students. The Health Literacy Knowledge and Experience Survey-2 (HLKES-2) is a measurement tool with excellent psychometric properties that can be used to assess the health literacy knowledge and experience of nursing students. In this study, we aimed to determine the validity and reliability of the Turkish version of the Health Literacy Knowledge and Experience Survey-2 (HLKES-2-T) among Turkish nursing students. The study sample consisted of 510 undergraduate nursing students. The psychometric properties of the HLKES-2-T were analysed in terms of internal consistency, item-total score correlations, content validity, discriminant validity and known-group comparison. The HLKES-2-T total mean ± SD score was 11.69 ± 3.32. The Kuder–Richardson 20 coefficient of the knowledge subscale of the HLKES-2-T was 0.67, and its item-total score correlations ranged between 0.20 and 0.50. The Cronbach’s alpha coefficient of the experience subscale of the HLKES-2-T was 0.73, and its item-total score correlations ranged between 0.75 and 0.78. The content validity index for the overall HLKES-2-T was 0.98. The HLKES-2-T is thus a reliable and valid tool that can be used to assess the health literacy knowledge and experience levels of Turkish nursing students.
Knowledge-based science in support of the blue growth ambition for small island developing states
Authors: Birchenough S N R 
Published: September 2023

Abstract
The “blue economy” idea promotes the responsible and sustainable use of coastal and marine resources. The need to balance the exploitation and economic use of these resources has moved to the top of the research agenda and management priorities for small island developing states (SIDS). SIDS face unique challenges due to their geographic, economic, and environmental characteristics. While the specific challenges can vary based on the individual SIDS, some common future challenges include (i) climate change and sea-level rise resulting from the increased frequency and intensity of storms and coastal erosion; (ii) natural disasters such as hurricanes, cyclones, tsunamis, and earthquakes, resulting in extensive damage, disruption of essential services, and lead to loss of lives and livelihoods; (iii) lack of sustainable development and economic diversification leading to reliance on few key sectors, such as tourism and agriculture, which are vulnerable to market fluctuations; (iv) energy security and renewable energy transition; as there is dependency on imported fossil fuels for their energy needs, price fluctuations and supply disruptions occurs; (v) biodiversity conservation and marine resource management; they host unique ecosystems and rich biodiversity, including coral reefs, mangroves, and marine species; and (vi) access to finance and technology; there are direct opportunities, for accessing funds to support technology development under sustainable finance projects. This themed article set attracted 14 submissions, 7 of which were accepted for publication. The topics covered fisheries, climate change effects, marine litter, and development of new technologies and finance mechanisms to support the SIDS. Overall, these contributions have emphasized the remarkable role that SIDS play in the protection and management of coastal and marine ecosystems, but also highlighted several needs and key priorities.
Surface sampling for SARS-CoV-2 RNA in workplace outbreak settings in the UK, 2021–22
Authors: Nicholls Ian , Spencer Antony , Chen Yiqun , Bennett Allan , Atkinson Barry 
Published: September 2023

Abstract

Aims
To utilize environmental surface sampling to evaluate areas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contamination within workplaces to identify trends and improve local coronavirus disease 2019 (COVID-19) control measures.

Methods and results
Surface sampling was undertaken at 12 workplaces that experienced a cluster of COVID-19 cases in the workforce between March 2021 and March 2022. A total of 7.4% (61/829) samples collected were positive for SARS-CoV-2 RNA by the quantitative PCR (qPCR) with only 1.8% (15/829) of samples identified with crossing threshold (Ct) values &lt;35.0. No sample returned whole-genome sequence inferring RNA detected was degraded.

Conclusions
Few workplace surface samples were positive for SARS-CoV-2 RNA and positive samples typically contained low levels of nucleic acid. Although these data may infer a low probability of fomite transmission within the workplace, Ct values may have been lower at the time of contamination. Workplace environmental sampling identified lapses in COVID-19 control measures within individual sites and showed trends throughout the pandemic.
Managing Ulcerative Colitis and Crohn’s Disease: Should the Target Be Endoscopy, Histology, or Both?
Authors: Magro Fernando , Estevinho Maria Manuela , Valois André 
Published: September 2023

Abstract
In inflammatory bowel disease (IBD), mucosal healing is the primary long-term treatment goal, encompassing both endoscopic and histological outcomes. This paper aims to overview the ability of new treatment options to promote endoscopic and histological healing and to discuss the prognostic significance of endoscopic and histological outcomes. The analysis included randomized-controlled trials (published since 2020) focused on the impact of pharmacological interventions on endoscopic and histological remission in IBD. Even though the Mayo endoscopic subscore is routinely used, the application of validated scoring systems for ulcerative colitis is uncommon. In Crohn’s disease (CD), the application of endoscopic scores remains limited to clinical studies. The standardized evaluation of histological features has been performed in several recent ulcerative colitis trials, resorting mostly to the Geboes score and the Nancy histological index. Still, the use of histological scores for CD remains elusive. Current evidence underscores that histological remission conveys the best long-term prognosis, supporting the inclusion of histology as a treatment guide in ulcerative colitis. In CD, data are promising but originated from a few retrospective studies. Further efforts are warranted to: (1) use validated histological indexes for ulcerative colitis, aiming their adoption as treatment targets; (2) promote the validation and utilization of histological scores for CD, at least in clinical studies; (3) confirm the prognostic impact of histological remission in CD; (4) integrate artificial intelligence assets to support grading, particularly in the setting of histology; (5) prospectively define the monitoring frequency of IBD patients who achieved histological remission.
Partial characterization of digestive proteases in the river prawn Macrobrachium americanum () (Decapoda: Caridea: Palaemonidae) in Mexico
Authors: Laguna-Nataren Victor M , Uscanga-Martínez Arkady , Perales-García Natalia , Álvarez-González Carlos A , López-Rasgado Francisco J , Díaz-Gallegos José R , Velazco-Ortiz Alexis F 
Published: September 2023

Abstract
We characterized the digestive enzymes in adults of Macrobrachium americanum (Spence Bate, 1868) in southeastern Mexico. The digestive enzyme extracts were made from the specimens’ hepatopancreas. Alkaline proteases, trypsin, chymotrypsin, carboxypeptidase A, leucine aminopeptidase, lipases, α-amylase and alkaline phosphatase activities were determined, as well as the percentage of inhibition, pH, and temperature stabilities through biochemical and electrophoretic techniques. The maximum digestive activity of proteases was at 35 °C and pH 11. Alkaline digestive proteases were highly stable at pHs 4, 9 and 11 at 55 °C after 30 min pre-incubation. PMSF inhibited two bands with proteolytic activity (35.1 and 23.2 kDa), and SBT1 inhibited all bands, including the one with the highest molecular weight (64.2 kDa). We concluded that enzymes in M. americanum coincide with those of omnivorous decapods with a tendency to carnivory.
An integrated workflow for pre-stack gather optimization
Authors: Zhou Jie , Zhou Huailai , Liu Junping , Sun Yaoguang 
Published: September 2023

Abstract
High-quality seismic data contribute to improving the prediction accuracy of complex reservoirs. Currently, there are several methods for enhancing pre-stack gather resolution and signal-to-noise ratio (SNR). Meanwhile, to avoid incorrect seismic interpretation, we must evaluate whether the processed data maintains its original characteristics and reliability. This paper establishes an integrated workflow for optimizing common-reflection-point (CRP) gather that is divided into processing and quality control. Furthermore, we summarize the comprehensive quality control means and explain their specific significance in each step. Data processing includes four parts: gather flattening, SNR enhancement, energy compensation, and resolution improvement. Simultaneously, we use well log data, forward simulation, stack data, and inversion to guarantee the processed data is optimized and keeps its original characteristics. Applications in carbonate reservoir CRP gathers demonstrate that this workflow can comprehensively optimize pre-stack seismic data and improve SNR and resolution. Importantly, the quality controls guarantee results have improved accuracy in reservoir prediction and stronger correlation coefficients with well data.
Coculturing liver cancer cells and monocytes in spheroids conditions monocytes to adopt tumor-associated macrophage phenotypes that favor tumor growth via cholesterol metabolism
Authors: Keawvilai Pornlapat , Kueanjinda Patipark , Klomsing Jeerameth , Palaga Tanapat 
Published: September 2023

Abstract
Tumor-infiltrating immune cells and their crosstalk with cancer cells in the tumor microenvironment (TME) play a crucial role in shaping tumor progression and response to therapy. We utilized 3-dimensional liver cancer spheroids incorporating human primary monocytes to investigate the crosstalk between tumor-associated macrophages (TAMs) and Hepatocellular carcinoma (HCC) cells, HepG2 and PLC/PRF/5. Using multiplexed gene expression panels, the critical pathways involved in shaping primary human monocytes to adopt TAMs phenotypes were identified. The specific inhibitor for an identified pathway was used to explore its involvement in polarization of TAMs. In the cocultured spheroids comprising the human HCC cell lines, the infiltrating monocytes resembled protumor M2-like macrophage phenotypes. Gene expression panels of the infiltrating monocytes demonstrated that the upregulated genes were enriched in the cholesterol metabolism pathway. Cholesterol metabolism–related genes were upregulated together with the nuclear receptors, PPARG and LXR. When lysosomal acid lipase (LAL), the key enzyme necessary for the hydrolysis of lipoprotein, was inhibited, infiltrating monocytes in 3-dimensional spheroid coculture showed significantly decreased M2 marker and lipid uptake receptor expression as well as increased cellular lipid content, which indicated that cholesterol metabolism was important for conditioning the TAMs. Moreover, LAL inhibition reduced the spheroid growth and invasiveness of HCC cell lines. Small interfering RNA–mediated LAL silencing in monocytes yielded similar results upon spheroid coculture. These data indicated that liver cancer cells and infiltrating monocytes participate in crosstalk via cholesterol metabolism to condition monocytes toward TAMs, which favors tumor growth and survival, thereby promoting liver cancer progression.
Why states refuse to participate in judicial proceedings: uncovering key reasons and historical evolution
Authors: Sun Ying 
Published: September 2023

Abstract
Over the past decade, non-participation in inter-state cases has been on the rise. While previous research on the topic has centred around the impact of states' non-participation, this article delves into the reasons behind non-participation. By analysing states’ public statements, diplomatic documents, informal correspondence with adjudicators, as well as commentators’ views, this article describes the evolution of reasons for non-participation. The research reveals that over time, more states refer to jurisdictional objections, doubts about the impartiality of adjudicators and concerns about the strategic use of judicial proceedings for achieving political goals as reasons for non-participation. Moreover, the reasons behind non-participation have become increasingly diverse. These findings suggest a growing sense of distrust and suspicion towards the use of international courts and tribunals to resolve inter-state disputes.
The impact of probiotic cell-free metabolites in MDRPseudomonas aeruginosa: antibacterial properties and effect on antibiotic resistance genes expression
Authors: Mehboudi Nastaran , Rahimi Hamid R , Bakhtiari H Aghaee , Alimardani Maliheh , Jalili Amin 
Published: September 2023

AbstractThere is a significant demand for novel antibacterial agents against multidrug-resistant (MDR) gram-negative bacteria. Recently, probiotics have been noted for their antibacterial properties against various pathogens. This study aimed to investigate the effects of probiotic cell-free supernatants on MDR Pseudomonas aeruginosa. Clinical isolates demonstrating the highest degree of antibiotic resistance were chosen, and the antibacterial effect of probiotic metabolites was evaluated using an agar-well diffusion assay. In addition, the effect of probiotics on the expression of resistance genes was evaluated using real-time PCR. The CFS was assessed using GC-MS to determine the antibacterial compounds. The supernatants inhibited the growth of the isolates (P &lt; 0.0001); however, there was no noticeable difference in the effectiveness of the probiotics. In addition, the supernatants decreased the expression levels of mexD, mexB, mexF, and ampC, and an increase in oprD was observed in some groups. After the assessment of Lactobacillus acidophilus by GC-MS, antibacterial compounds, such as acetamide, nonadecane, 9-methyl, and tetradecane, were determined. Our findings showed that probiotic metabolites can effectively inhibit the growth of MDR P. aeruginosa. Gene expression analysis also revealed that the mechanism of antibacterial action was most likely related to the regulation of efflux pumps.
Into the Mystic: ALMA ACA observations of the Mystic Mountains in Carina
Authors: Reiter Megan , Klaassen P D , Moser-Fischer L , McLeod A F , Itrich D 
Published: September 2023

ABSTRACT
We present new observations of the Mystic Mountains cloud complex in the Carina Nebula using the ALMA Atacama Compact Array (ACA) to quantify the impact of strong UV radiation on the structure and kinematics of the gas. Our Band 6 observations target CO, 13CO, and C18O; we also detect DCN J=3–2 and 13CS J=5–4. A dendrogram analysis reveals that the Mystic Mountains are a coherent structure, with continuous emission over −10.5 km s−1 &lt; v &lt; −2 km s−1. We perform multiple analyses to isolate non-thermal motions in the Mystic Mountains including computing the turbulent driving parameter, b, which indicates whether compressive or solenoidal modes dominate. Each analysis yields values similar to other pillars in Carina that have been observed in a similar way but are subject to an order of magnitude less intense ionizing radiation. We find no clear correlation between the velocity or turbulent structure of the gas and the incident radiation, in contrast to other studies targeting different regions of Carina. This may reflect differences in the initial densities of regions that go on to collapse into pillars and those that still look like clouds or walls in the present day. Pre-existing over-densities that enable pillar formation may also explain why star formation in the pillars appears more evolved (from the presence of jets) than in other heavily irradiated but non-pillar-like regions. High resolution observations of regions subject to an array of incident radiation are required to test this hypothesis.
Planetesimals at DZ stars – I. Chondritic compositions and a massive accretion event
Authors: Swan Andrew , Farihi Jay , Melis Carl , Dufour Patrick , Desch Steven J , Koester Detlev , Guo Jincheng 
Published: September 2023

ABSTRACT
There is a wealth of evidence to suggest that planetary systems can survive beyond the main sequence. Most commonly, white dwarfs are found to be accreting material from tidally disrupted asteroids, whose bulk compositions are reflected by the metals polluting the stellar photospheres. While many examples are known, most lack the deep, high-resolution data required to detect multiple elements, and thus characterize the planetesimals that orbit them. Here, spectra of seven DZ white dwarfs observed with Keck High Resolution Echelle Spectrometer (HIRES) are analysed, where up to nine metals are measured per star. Their compositions are compared against those of Solar system objects, working in a Bayesian framework to infer or marginalize over the accretion history. All of the stars have been accreting primitive material, similar to chondrites, with hints of a Mercury-like composition at one star. The most polluted star is observed several Myr after its last major accretion episode, in which a Moon-sized object met its demise.
Probing the nature of the X-ray source IGR J16327-4940 with Chandra
Authors: Sidoli L , Sguera V , Postnov K , Esposito P , Oskinova L , Mereminskiy I A 
Published: September 2023

ABSTRACT
We report on the results of a Chandra observation of the source IGR J16327-4940, suggested to be a high-mass X-ray binary hosting a luminous blue variable star (LBV). The source field was imaged by ACIS-I in 2023 to search for X-ray emission from the LBV star and eventually confirm this association. No X-ray emission is detected from the LBV star, with an upper limit on the X-ray luminosity of L$_{\rm 0.5-10 \,keV}\lt 2.9(^{+1.6} _{-1.1})\times 10^{32}$ erg s−1 (at the LBV distance d = 12.7$^{+3.2} _{-2.7}$ kpc). We detected 21 faint X-ray sources, 8 of which inside the INTEGRAL error circle. The brightest one is the best candidate soft X-ray counterpart of IGR J16327-4940, showing a hard power-law spectrum and a flux corrected for the absorption UF0.5–10 keV = 2.5 × 10−13 erg cm−2 s−1, implying a luminosity of 3.0 × 1033 d$_{10~{\rm kpc}}^2$ erg s−1. No optical/near-infrared counterparts have been found. Previous X–ray observations of the source field with Swift/XRT and ART-XC did not detect any source consistent with the INTEGRAL position. These findings exclude the proposed LBV star as the optical association, and pinpoint the most likely soft X-ray counterpart. In this case, the source properties suggest a low-mass X-ray binary, possibly a new member of the very faint X-ray transient class.