bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Cancer Excisions and Histopathology Outcomes When Following a Contemporary Population-Based Cohort Longitudinally with 3D Total-Body Photography
Authors: Soyer H. Peter , O’Hara Montana , Silva Carina V. , Horsham Caitlin , Jayasinghe Dilki , Sanjida Saira , Schaider Helmut , Aitken Joanne , Sturm Richard A. , Prow Tarl , Menzies Scott W. , Janda Monika 
Published: January 2023

Abstract

Background
Skin cancer represents a significant health burden across the globe and early detection is critical to improve health outcomes. Three-dimensional (3D) total-body photography is a new and emerging technology which can support clinicians when they monitor people's skin over time.

Objectives
The aim of this study was to improve our understanding of the epidemiology and natural history of melanocytic naevi in adults, and their relationship with melanoma and other skin cancers.

Methods
Mind Your Moles was a 3-year prospective, population-based cohort study which ran from December 2016 to February 2020. Participants visited the Princess Alexandra Hospital every 6 months for 3 years to undergo both a clinical skin examination and 3D total-body photography.

Results
A total of 1213 skin screening imaging sessions were completed. Fifty-six percent of participants (n = 108/193) received a referral to their own doctor for 250 lesions of concern, 101/108 (94%) for an excision/biopsy. Of those, 86 people (85%) visited their doctor and received an excision/biopsy for 138 lesions. Histopathology of these lesions found 39 non-melanoma skin cancers (across 32 participants) and six in situ melanomas (across four participants).

Conclusions
3D total-body imaging results in diagnosis of a high number of keratinocyte cancers (KCs) and their precursors in the general population.
Leveraging β‐Adrenergic Receptor Signaling Blockade for Improved Cancer Immunotherapy Through Biomimetic Nanovaccine
Authors: Yang Chao , He Yi , Chen Fangman , Zhang Fan , Shao Dan , Wang Zheng 
Published: January 2023

AbstractThe establishment of effective antitumor immune responses of vaccines is mainly limited by insufficient priming tumor infiltration of T cells and immunosuppressive tumor microenvironment (TME). Targeting β‐adrenergic receptor (β‐AR) signaling exerts promising benefits on reversing the suppressive effects directly on T cells, but it appears to have considerably limited antitumor performance when combined with vaccine‐based immunotherapies. Herein, a tumor membrane‐coated nanoplatform for codelivery of adjuvant CpG and propranolol (Pro), a β‐AR inhibitor is designed. The biomimetic nanovaccine displayed an improved accumulation in lymph nodes and sufficient drug release, thereby inducing dendritic cell maturation and antigen presentation. Meanwhile, the integration of vaccination and blockade of β‐AR signaling not only promoted the priming of the naive CD8+ T cells and effector T cell egress from lymph nodes, but also alleviated the immunosuppressive TME by decreasing the frequency of immunosuppressive cells and increasing the tumor infiltration of B cells and NK cells. Consequently, the biomimetic nanovaccines outperformed greater prophylactic and therapeutic efficacy than nanovaccines without Pro encapsulation in B16‐F10 melanoma mice. Taken together, the work explored a biomimetic nanovaccine for priming tumor infiltration of T cells and immunosuppressive TME regulation, offering tremendous potential for a combined β‐AR signaling‐targeting strategy in cancer immunotherapy.
Enantioselective Synthesis of Spiro Heterocyclic Compounds Using a Combination of Organocatalysis and Transition‐Metal Catalysis
Authors: Kamlar Martin , Urban Michal , Veselý Jan 
Published: January 2023

AbstractOver the last ten years, the combination of organocatalysis with transition metal (TM) catalysis has become one of the most important toolboxes used for synthesizing optically pure compounds containing chiral quaternary centers, including spiro heterocyclic molecules. The dominant method in the enantioselective synthesis of spiro heterocyclic compounds based on synergistic catalysis includes chiral aminocatalysis and NHC catalysis, as already established covalent organocatalytic strategies. Another area of organocatalysis widely combined with TM catalysis producing enantiomerically enriched spiro heterocyclic compounds is non‐covalent catalysis, dominated by chiral phosphoric acids, thiourea, and squaramide derivatives. This review article aims to summarize enantioselective methods used for constructing spirocyclic heterocycles based on a combination of organocatalysis and transition metal catalysis.
Fatal necro‐haemorrhagic gastroenteritis and multifocal microthrombi secondary to food engorgement in a dog
Authors: Talbot Charles T. , Fisher Corey J. , Oates Andrew W. , Zersen Kristin M. 
Published: January 2023

AbstractA previously healthy 5‐year‐old, female, spayed, mixed breed dog presented for acute abdominal distension and non‐productive retching after consuming a large volume of kibble dog food. Abdominal radiographs confirmed food engorgement, and standard medical therapy was initiated with intravenous fluids and analgesics. After 36 hours of persistent abdominal distension and progressive hyperlactatemia, an exploratory laparotomy revealed generalised ischaemia throughout the gastrointestinal tract, spleen, and liver. Due to a poor prognosis, humane euthanasia was elected. Postmortem examination confirmed severe necro‐haemorrhagic gastroenteritis and multifocal microthrombi.Clostridium perfringenswas cultured from the small intestines, which may represent either an underlying cause or an opportunistic proliferation.
A novel multi fractional comparative analysis of second law analysis of MHD flow of Casson nanofluid in a porous medium with slipping and ramped wall heating
Authors: Khan Dolat , Kumam Poom , Watthayu Wiboonsak , Yassen Mansour F. 
Published: January 2023

AbstractFractional calculus gets more attention in applied and pure science from the last two decay due to their valuable contribution. Due to extensive applications of fractional derivatives, the main aim of this article is focused on the multi fractional comparative study of entropy generation of magnetohydrodynamic (MHD) flow of Casson nanofluid with slipping and ramped wall heating effect on the plate. Set of partial differential equations forms governing equation and by using constant proportional–Caputo hybrid (CPC), Atangana–baleanu (AB) and Caputo Fabrizio (CF) fractional derivative generalized the model. Using the Laplace transform approach, a closed form of the solution is attained. Entropy production for Casson nanofluid is explored and compared using triple fractional modelled and for four different nanoparticles. Furthermore, the Bejan number is compared for the previously mentioned fractional derivatives. The graphs depict the effect of several parameters on the minimization and maximisation of multi generalised entropy generation. Instead of Atangana–baleanu and Caputo Fabrizio fractional operators, the newly proportional Caputo hybrid operator has a strong memory effect. It is concluded that CPC fractional model is more realistic then other two fractional model in case of ramped wall temperature while in case of isothermal wall temperature the results are vice versa.
Thermal performance of a longitudinal fin under the influence of magnetic field using Sumudu transform method with pade approximant (STM‐PA)
Authors: Sowmya Ganeshappa , Kumar Ravikumar Shashikala Varun , J Madhu , Banu Yasmeen 
Published: January 2023

AbstractTemperature distribution, and efficiency of a rectangular profiled longitudinal fin are examined in this investigation with the impact of the magnetic field. By exploiting appropriate non‐dimensional terms, the heat transfer equation incorporating temperature‐dependent thermal conductivity, heat transfer coefficient, and Maxwell expression for the effect of the magnetic field yield a dimensionless nonlinear ordinary differential equation (ODE) with corresponding boundary conditions (BCs). Sumudu transform method with Pade approximant (STM‐PA) has been employed to obtain an analytical solution for the temperature profile of a longitudinal rectangular fin subjected to a uniform magnetic field under multi‐boiling heat transfer. The STM‐PA results are compared to the Runge‐Kutta Fehlberg's fourth‐fifth (RKF‐45) order technique for computational verification and are observed to be in good accordance. The behavior of dimensionless temperature profile has been explicated graphically for diverse values of non‐dimensional parameters such as thermal conductivity parameter, Hartmann number, and thermogeometric parameter. The results of this study show that as the thermal conductivity parameter enriches, the temperature profile of the longitudinal fin improves, whereas it declines for the Hartmann number and thermogeometric parameter. Under multi‐boiling heat transference, fin efficiency varies significantly depending on the impact of pertinent variables.
Problemstellung
Authors: Müller Jana Katharina 
Published: January 2023

ZusammenfassungBilanzierungssysteme haben die Aufgabe, die unternehmerische Realität in modellhafter Weise abzubilden und so der jeweiligen Zwecksetzung gerecht zu werden. Immaterielle Werte stellen einen wichtigen Teil der gegenwärtigen unternehmerischen Realität dar und gewinnen, u. a. durch die zunehmende Digitalisierung, stetig an Bedeutung. Insbesondere die Beziehungen zwischen Unternehmen und Kunden spielen eine besondere Rolle für den Wertschöpfungsprozess, denn jedes profitorientierte Unternehmen existiert durch die Nachfrage seiner Kunden.
Rechnungslegungsordnung
Authors: Müller Jana Katharina 
Published: January 2023

ZusammenfassungAlle Kaufleute sind gemäß § 243 Abs. 1 HGB zur Aufstellung ihres Jahresabschluss „nach den Grundsätzen ordnungsmäßiger Buchführung“ verpflichtet; aufgrund der Verortung dieser Norm im ersten Abschnitt des HGB stellen die GoB eine Generalnorm dar, die für alle Kaufleute, d. h. neben Personengesellschaften insbesondere auch für Kapitalgesellschaften, den Kern der Bilanzierung bilden. „[U]m einen vielgestaltigen Sachverhalt des Rechtslebens zu regeln und um den Regelungsinhalt des Gesetzes für den Wandel der Verhältnisse und Anschauungen offenzuhalten“, sind die GoB einerseits als unbestimmter Rechtsbegriff konzipiert, andererseits den Einzelgrundsätzen vorangestellt. Seit den 1960er Jahren wurde das bis dahin aus dem Aktienrecht bekannte Normverständnis rechtsformunabhängig angewendet und auf das Verständnis handelsrechtlicher GoB übertragen; diese werden seitdem – spätestens aber seit der gesetzlichen Kodifizierung einzelner „oberer GoB“, bspw. die für alle Vermögensgegenstände und Schulden geltenden allgemeinen Bewertungsgrundsätze gemäß § 252 Abs. 1 HGB, durch das Bilanzrichtlinien-Gesetz von 1985 – als grundsätzlich öffentlich-rechtliche Normen verstanden.
GoB-System als Grundlage der Bilanzierung von Kundenbeziehungen und Vergleich mit der Bilanzierung nach IFRS
Authors: Müller Jana Katharina 
Published: January 2023

ZusammenfassungDie GoB zur Bestimmung eines aktivierungsfähigen Vermögensgegenstands sind grundsätzlich sowohl für materielle als auch für immaterielle Vorteile anzuwenden. Teilweise wird für die Konkretisierung sowohl gesetzlich (so das Aktivierungswahlrecht des § 248 Abs. 2 S. 1 HGB) als auch implizit aufgrund der bei immateriellen Werten bestehenden Unsicherheiten eine Abgrenzung gefordert, sodass eine Definition dessen, was unter den Begriff Immaterialität subsumiert werden kann, für eine GoB-konforme Auslegung zwingend notwendig ist.
Alternative Konkretisierung des Vermögensbegriffs auf Grundlage der Property-Rights-Theorie
Authors: Müller Jana Katharina 
Published: January 2023

ZusammenfassungDie bisherige Darstellung und Analyse der gegenwärtigen Regelungen zur Aktivierung immaterieller Güter haben verdeutlicht, dass sich bisher sowohl nach GoB als auch nach IFRS keine eindeutigen und gefestigten Kriterien herausgebildet haben, die der Anforderung einer objektivierten und gleichzeitig die tatsächlichen wirtschaftlichen Gegebenheiten abbildenden Bilanzierung gerecht werden. Aus diesem Grund soll eine alternative Konzeption auf Basis der Bilanzierung von Property Rights auf ihre Tauglichkeit und einen möglichen Mehrwert hin geprüft werden. Das Abstellen auf Property Rights, die sich an der „Schnittstelle zwischen der juristischen und der ökonomischen Welt“ bewegen, kann möglicherweise – und stets unter Einbezug der in den Rechnungslegungssystemen geltenden Maßstäbe – zu einer Konkretisierung der Kriterien beitragen.
Thesenförmige Zusammenfassung
Authors: Müller Jana Katharina 
Published: January 2023

ZusammenfassungDie Aktivierungsfähigkeit immaterieller Werte ist nach gegenwärtiger GoB- und IFRS-Bilanzierung nicht nur von ihrer inhaltlichen Ausgestaltung, sondern auch von ihrer Entstehung abhängig. Immaterielle Werte können dem bilanzierenden Unternehmen durch einen separaten Kauf, einen Kauf im Zuge eines Unternehmenserwerbs oder durch Selbsterstellung zugehen. Dies gilt auch für Kundenbeziehungen.
Fear of AI: an inquiry into the adoption of autonomous cars in spite of fear, and a theoretical framework for the study of artificial intelligence technology acceptance
Authors: Cugurullo Federico , Acheampong Ransford A. 
Published: January 2023

AbstractArtificial intelligence (AI) is becoming part of the everyday. During this transition, people’s intention to use AI technologies is still unclear and emotions such as fear are influencing it. In this paper, we focus on autonomous cars to first verify empirically the extent to which people fear AI and then examine the impact that fear has on their intention to use AI-driven vehicles. Our research is based on a systematic survey and it reveals that while individuals are largely afraid of cars that are driven by AI, they are nonetheless willing to adopt this technology as soon as possible. To explain this tension, we extend our analysis beyond just fear and show that people also believe that AI-driven cars will generate many individual, urban and global benefits. Subsequently, we employ our empirical findings as the foundations of a theoretical framework meant to illustrate the main factors that people ponder when they consider the use of AI tech. In addition to offering a comprehensive theoretical framework for the study of AI technology acceptance, this paper provides a nuanced understanding of the tension that exists between the fear and adoption of AI, capturing what exactly people fear and intend to do.
Characteristics associated with subjective and objective measures of treatment success in women undergoing percutaneous tibial nerve stimulation vs sham for accidental bowel leakage
Authors: Luchristt Douglas , Carper Benjamin , Balgobin Sunil , Meyer Isuzu , Myers Deborah , Mazloomdoost Donna , Gantz Marie , Andy Uduak , Zyczynski Halina M. , Lukacz Emily S. ,   On behalf of the Pelvic Floor Disorders Network, Zyczynski Halina M. , Richter Holly E. , Sung Vivian W. , Lukacz Emily S. , Arya Lily A. , Rahn David D. , Visco Anthony G. , Mazloomdoost Donna , Carper Benjamin , Gantz Marie G. 
Published: January 2023

Abstract
Introduction and hypothesis
In randomized trials both percutaneous tibial nerve stimulation (PTNS) and sham result in clinically significant improvements in accidental bowel leakage (ABL). We aimed to identify subgroups who may preferentially benefit from PTNS in women enrolled in a multicenter randomized trial.

Methods
This planned secondary analysis explored factors associated with success for PTNS vs sham using various definitions: treatment responder using three cutoff points for St. Mark’s score (≥3-, ≥4-, and ≥5-point reduction); Patient Global Impression of Improvement (PGI-I) of ≥ much better; and ≥50% reduction in fecal incontinence episodes (FIEs). Backward logistic regression models were generated using elements with significance of p<0.2 for each definition and interaction terms assessed differential effects of PTNS vs sham.

Results
Of 166 women randomized, 160 provided data for at least one success definition. Overall, success rates were 65% (102 out of 158), 57% (90 out of 158), and 46% (73 out of 158) for ≥3-, ≥4-, and ≥5-point St Mark’s reduction respectively; 43% (68 out of 157) for PGI-I; and 48% (70 out of 145) for ≥50% FIEs. Of those providing data for all definitions of success, 77% (109 out of 142) met one success criterion, 43% (61 out of 142) two, and 29% (41 out of 142) all three success criteria. No reliable or consistent factors were associated with improved outcomes with PTNS over sham regardless of definition.

Conclusions
Despite exploring diverse success outcomes, no subgroups of women with ABL differentially responded to PTNS over sham. Success results varied widely across subjective and objective definitions. Further investigation of ABL treatment success definitions that consistently and accurately capture patient symptom burden and improvement are needed.
Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line
Authors: Malinowska Julia M. , Palosaari Taina , Sund Jukka , Carpi Donatella , Weber Ralf J. M. , Lloyd Gavin R. , Whelan Maurice , Viant Mark R. 
Published: January 2023

AbstractAmongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the closest to traditional apical endpoints, whilst offering mechanistic insights into the biological perturbations. Despite this, the application of untargeted metabolomics for point-of-departure (POD) derivation via benchmark concentration (BMC) modelling is still a relatively unexplored area. In this study, a high-throughput workflow was applied to derive PODs associated with a chemical exposure by measuring the intracellular metabolome of the HepaRG cell line following treatment with one of four chemicals (aflatoxin B1, benzo[a]pyrene, cyclosporin A, or rotenone), each at seven concentrations (aflatoxin B1, benzo[a]pyrene, cyclosporin A: from 0.2048 μM to 50 μM; rotenone: from 0.04096 to 10 μM) and five sampling time points (2, 6, 12, 24 and 48 h). The study explored three approaches to derive PODs using benchmark concentration modelling applied to single features in the metabolomics datasets or annotated metabolites or lipids: (1) the 1st rank-ordered unannotated feature, (2) the 1st rank-ordered putatively annotated feature (using a recently developed HepaRG-specific library of polar metabolites and lipids), and (3) 25th rank-ordered feature, demonstrating that for three out of four chemical datasets all of these approaches led to relatively consistent BMC values, varying less than tenfold across the methods. In addition, using the 1st rank-ordered unannotated feature it was possible to investigate temporal trends in the datasets, which were shown to be chemical specific. Furthermore, a possible integration of metabolomics-driven POD derivation with the liver steatosis adverse outcome pathway (AOP) was demonstrated. The study highlights that advances in technologies enable application of in vitro metabolomics at scale; however, greater confidence in metabolite identification is required to ensure PODs are mechanistically anchored.
A highly sensitive LC-MS/MS method for quantitative determination of 7 vitamin D metabolites in mouse brain tissue
Authors: Stephenson Andrea Joy , Hunter Benjamin , Shaw Paul Nicholas , Kassim Nur Sofiah Abu , Trengove Robert , Takechi Ryu , Lam Virginie , Mamo John 
Published: January 2023

Abstract
Despite its critical role in neurodevelopment and brain function, vitamin D (vit-D) homeostasis, metabolism, and kinetics within the central nervous system remain largely undetermined. Thus, it is of critical importance to establish an accurate, highly sensitive, and reproducible method to quantitate vit-D in brain tissue. Here, we present a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) method and for the first time, demonstrate detection of seven major vit-D metabolites in brain tissues of C57BL/6J wild-type mice, namely 1,25(OH)2D3, 3-epi-1,25(OH)2D3, 1,25(OH)2D2, 25(OH)D3, 25(OH)D2, 24,25(OH)2D3, and 24,25(OH)2D2. Chromatographic separation was achieved on a pentaflurophenyl column with 3 mM ammonium formate water/methanol [A] and 3 mM ammonium formate methanol/isopropanol [B] mobile phase components. Detection was by positive ion electrospray tandem mass spectrometry with the EVOQ elite triple quadrupole mass spectrometer with an Advance ultra-high-performance liquid chromatograph and online extraction system. Calibration standards of each metabolite prepared in brain matrices were used to validate the detection range, precision, accuracy, and recovery. Isotopically labelled analogues, 1,25(OH)2D3-d3, 25(OH)D3-c5, and 24,25(OH)2D3-d6, served as the internal standards for the closest molecular-related metabolite in all measurements. Standards between 1 fg/mL and 10 ng/mL were injected with a resulting linear range between 0.001 and 1 ng, with an LLOD and LLOQ of 1 pg/mL and 12.5 pg/mL, respectively. The intra-/inter-day precision and accuracy for measuring brain vit-D metabolites ranged between 0.12–11.53% and 0.28–9.11%, respectively. Recovery in acetonitrile ranged between 99.09 and 106.92% for all metabolites. Collectively, the sensitivity and efficiency of our method supersedes previously reported protocols used to measure vit-D and to our knowledge, the first protocol to reveal the abundance of 25(OH)D2, 1,25(OH)D2, and 24,25(OH)2D2, in brain tissue of any species. This technique may be important in supporting the future advancement of pre-clinical research into the function of vit-D in neurophysiological and neuropsychiatric disorders, and neurodegeneration.
Graphical Abstract
Prediction of sensory attributes in winemaking grapes by on-line near-infrared spectroscopy based on selected volatile aroma compounds
Authors: Gehlken Jana , Pour Nikfardjam Martin , Zörb Christian 
Published: January 2023

AbstractAroma represents an important quality aspect for wine. The aroma of different grapes and wines is formed by the varying composition and concentrations of numerous aroma compounds, which result in different sensory impressions. The analysis of aroma compounds is usually complex and time-consuming, which requires the development of rapid alternative methods. In this study, grape mash samples were examined for aroma compounds, which were released under tasting conditions. A selection of the determined aroma compounds was grouped according to their sensory characteristics and calibration models were developed for the determination of sensory attributes by near-infrared (NIR) spectroscopy. The calibration models for the selected sensory attributes “fruity,” “green,” “floral” and “microbiological” showed very high prediction accuracies (0.979 < R2C < 0.996). Moreover, four different grape model solutions, whose compositions were based on the results from GC–MS-based analysis of the grape mash samples, were examined in a sensory evaluation. Despite large variation of the single values, the averaged values of the given scores for intensity of odour and taste showed differences between the model solutions for most of the evaluated sensory attributes. Sensory analysis remains essential for the evaluation of the overall aroma; however, NIR spectroscopy can be used as an additional and more objective method for the estimation of possible desired or undesired flavour nuances of grape mash and the quality of the resulting wine.
Graphical Abstract