bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verapamil Prevents Decline of IGF-I in Subjects With Type 1 Diabetes and Promotes β-Cell IGF-I Signaling
Authors: Xu Guanlan , Chen Junqin , Lu Brian , Sethupathy Praveen , Qian Wei-Jun , Shalev Anath 
Published: July 2023

Verapamil promotes functional β-cell mass and improves glucose homeostasis in diabetic mice and humans with type 1 diabetes (T1D). Now, our global proteomics analysis of serum from subjects with T1D at baseline and after 1 year of receiving verapamil or placebo revealed IGF-I as a protein with significantly changed abundance over time. IGF-I, which promotes β-cell survival and insulin secretion, decreased during disease progression, and this decline was blunted by verapamil. In addition, we found that verapamil reduces β-cell expression of IGF-binding protein 3 (IGFBP3), whereas IGFBP3 was increased in human islets exposed to T1D-associated cytokines and in diabetic NOD mouse islets. IGFBP3 binds IGF-I and blocks its downstream signaling, which has been associated with increased β-cell apoptosis and impaired glucose homeostasis. Consistent with the downregulation of IGFBP3, we have now discovered that verapamil increases β-cell IGF-I signaling and phosphorylation/activation of the IGF-I receptor (IGF1R). Moreover, we found that thioredoxin-interacting protein (TXNIP), a proapoptotic factor downregulated by verapamil, promotes IGFBP3 expression and inhibits the phosphorylation/activation of IGF1R. Thus, our results reveal IGF-I signaling as yet another previously unappreciated pathway affected by verapamil and TXNIP that may contribute to the beneficial verapamil effects in the context of T1D.

Article Highlights
Verapamil prevents the decline of IGF-I in subjects with type 1 diabetes (T1D). Verapamil decreases the expression of β-cell IGF-binding protein 3 (IGFBP3), whereas IGFBP3 is increased in human and mouse islets under T1D conditions. Verapamil promotes β-cell IGF-I signaling by increasing phosphorylation of IGF-I receptor and its downstream effector AKT. Thioredoxin-interacting protein (TXNIP) increases IGFBP3 expression and inhibits the phosphorylation/activation of IGF1R in β-cells. Regulation of IGFBP3 and IGF-I signaling by verapamil and TXNIP may contribute to the beneficial verapamil effects in the context of T1D.
EXPLORING GENDER DIFFERENCES IN USING METADISCOURSE FOR POLITICAL OPINION WRITING
Authors: Ramash Nur Syahira , Ng Lay Shi 
Published: July 2023

Background and Purpose: Metadiscourse marker is one of the most commonly-used linguistic devices in persuasive writing, and it shapes writer’s arguments to the needs and expectations of the target readers. Research has consistently shown that women, on average, are less politically interested, informed, and efficacious than men. However, this does not necessarily imply that male columnists are more persuasive than female columnists when writing political opinion articles. Hence, the present study aims to investigate how male and female columnists use metadiscourse markers in political opinion writing to effectively direct their political views toward their readers.

Methodology: This descriptive study used frequency analysis, comparative analysis, and a semi-structured interview with eight ardent readers to examine metadiscourse markers used by male and female columnists in their political opinion articles, as well as the impact of persuasion on their readers. 100 opinion articles about Malaysia's 14th general election were chosen from two English-language online newspaper portals in Malaysia, The Star and the New Straits Times.

Findings: The findings revealed that female columnists employed more metadiscourse markers than male columnists. Respondents concluded that articles with more metadiscourse markers used in the text, particularly in the interpersonal category, appeared to be more persuasive. Furthermore, the findings indicated that female columnists presented a more convincing image than those produced by male columnists.

Contributions: As research conducted on gender differences in political writing is still rare, this research provided information regarding gender preferences in using metadiscourse markers in political opinion articles. This study contributes to the body of knowledge by informing researchers and opinion writers about the many types of metadiscourse markers that may be used to establish rapport between writers and readers.

Keywords: Metadiscourse markers, persuasive writing, gender, male, female, political-opinion articles.

Cite as: Ramash, N. S., & Ng, L. S. (2023). Exploring gender differences in using metadiscourse for political opinion writing. Journal of Nusantara Studies, 8(1), 333-356. http://dx.doi.org/10.24200/jonus.vol8iss1pp333-356
THE EFFECT OF BLENDED LEARNING TOWARDS PUPILS’ VOCABULARY DEVELOPMENT AND MOTIVATION IN AN ESL CLASSROOM
Authors: Hong Andy Lim Teik , Stapa Mahani 
Published: July 2023

Background and Purpose: Vocabulary is the fundamental aspect of a language. However, second language (L2) learners often perceive vocabulary learning as boring and difficult. As such, various efforts must be made by teachers to empower pupils’ vocabulary base to be able to be competent in the target language. Hence, this study attempts to address the use of blended learning on pupils’ vocabulary development and motivation.

Methodology: This research adopted the quantitative research design. The research participants consisted of two classes of primary school pupils chosen through purposive sampling. The pupils were divided into the experimental group and the control group. The instruments used were pre-test, post-test, and questionnaires. An independent t-test was used to compare the mean score to see any significant difference in terms of pupils’ pre-test and post-test scores whereas mean interpretation was used to determine pupils’ level of motivation.

Findings: The results revealed that pupils who learned through blended learning performed better in terms of vocabulary development compared to the pupils who learned through traditional learning. Similarly, pupils have high motivation towards blended learning instructions. It is apparent that pupils become motivated learners when their need for autonomy, competence, and relatedness are fulfilled.

Contributions: This research aids teachers in constructing suitable blended learning environments for content delivery as an alternative way for students to interact with information in preparation for classroom work.
Keywords: Blended learning, vocabulary development, motivation, ESL classroom, purposive sampling.

Cite as: Teik Hong, A. L., & Stapa, M. (2023). The effect of blended learning towards pupils’ vocabulary development and motivation in an ESL classroom. Journal of Nusantara Studies, 8(1), 406-428. http://dx.doi.org/10.24200/jonus.vol8iss1pp406-428
Numeric Fem’s Solution for Space-Time Diffusion Partial Differential Equations with Caputo–Fabrizion and Riemann–Liouville Fractional Order’s Derivatives
Authors: Boutiba Malika , Baghli-Bendimerad Selma , Fečkan Michal 
Published: July 2023

Abstract
In this paper, we use the finite element method to solve the fractional space-time diffusion equation over finite fields. This equation is obtained from the standard diffusion equation by replacing the first temporal derivative with the new fractional derivative recently introduced by Caputo and Fabrizion and the second spatial derivative with the Riemann–Liouville fractional derivative. The existence and uniqueness of the numerical solution and the result of error estimation are given. Numerical examples are used to support the theoretical results.
A review on the epigenetics modifications to nanomaterials in humans and animals: Novel epigenetic regulator
Authors: Aldal’in Hammad K. , Radhi Khadija S. , Alazragi Reem , Abdelnour Sameh , Abukhalil Mohammad H. , Askar Ahmed M. , Khalifa Norhan E. , Noreldin Ahmed E. , Althunibat Osama Y. , Arif Muhammad , Abd El-Hack Mohamed E. 
Published: July 2023

Abstract
In the nanotechnology era, nanotechnology applications have been intensifying their prospects to embrace all the vigorous sectors persuading human health and animal. The safety and concerns regarding the widespread use of engineered nanomaterials (NMs) and their potential effect on human health still require further clarification. Literature elucidated that NMs exhibited significant adverse effects on various molecular and cellular alterations. Epigenetics is a complex process resulting in the interactions between an organism’s environment and genome. The epigenetic modifications, including histone modification and DNA methylation, chromatin structure and DNA accessibility alteration, regulate gene expression patterns. Disturbances of epigenetic markers induced by NMs might promote the sensitivity of humans and animals to several diseases. Also, this paper focuses on the epigenetic regulators of some dietary nutrients that have been confirmed to stimulate the epigenome and, more exactly, DNA histone modifications and non-histone proteins modulation by acetylation, and phosphorylation inhibition, which counteracts oxidative stress generations. The present review epitomizes the recent evidence of the potential effects of NMs on histone modifications, in addition to in vivo and in vitro cytosine DNA methylation and its toxicity. Furthermore, the part of epigenetic fluctuations as possible translational biomarkers for uncovering untoward properties of NMs is deliberated.
First record of Hyperphyscia coralloides (L.) Scutari growing on PET plastic within a fruit crops plot and its implications
Authors: Gomez Jonatan , Nistal Ayelen , Villagra Elizabeth , Dettler María Antonela , Vazquez Florencia Anabella 
Published: July 2023

Abstract
In a fruit crop located in the Lujan district (Buenos Aires province, Argentina), we exposed plastic bottles to the environment for three years. We explored microplastics’ presence on thalli. Out of the potential five lichen species only one grew: Hyperphyscia coralloides. Microplastic particles were observed on the thalli. The present work represents the first record of H. coralloides growing on PET plastic. Considering the largest thalli size recorded, the results of the growth rate are similar in an average to those recorded for fruticose species. Finally, our results suggest that the contact of H. coralloides with microplastics may be a potential pathway for the incorporation of microplastics into ecosystems.
Does Digitalization Accelerate the Winner-Takes-All Effect in the Sports Industry?
Authors: Glebova Ekaterina , Terrien Mickaël , Desbordes Michel 
Published: July 2023

Abstract
Today media and sports are indivisible, having a kind of inseparable, mutually influential relationship. Media attracts audiences and generates profit through sports. In its turn, sports content is disseminated, transmitted, and popularized through the media. Thus, theoretically, sports and media exist in symbiosis. However, practically, this relationship is complex and includes many factors. First of all, in recent decades, the process of overall digitalization (and digital transformation) of all fields of life has had a crucial impact on sport, media, and their interrelationship. This paper aims to conceptualize and analyze the possible impact of digitalization on “winner-takes-all” (WTA) (winner-takes-most, WTM) dynamics in the professional sports industry, notably for spectating audiences, and answer the question: “Can digitalization be seen as a driver of ecosystem change and how it should be tested?” This conceptual model paper seeks to construct and develop a theoretical framework that can explain and predict relationships between concepts of digitalization and key sport spectating variables: audience, TV rights, and revenue through a prism of WTA. We found that the technological change in the sports media market and the greater global-orientated strategy of leading sports organizations have re-sorted and compressed many market shares, but the effect of technological disruption has been significantly less pronounced for the most powerful digital leaders in the industry. To this end, we represent digitalization as the main accelerating factor of the WTA effect (along with other auxiliary effects) in the sports industry and propose future research directions and perspectives.
Geology and Rare Earth Element Geochemistry of Magnesian Granitoids Within Proterozoic Schist Belt of Southwest Nigeria
Authors: Okunola Olufemi Williams , Olatunji Akinade Shadrach , Afolabi Adegoke Olukayode 
Published: July 2023

Abstract
The increased global demand for and price of rare earth elements (REEs) has led to intensive search for them in rocks of the upper continental crust all over the world. This study is aimed at characterising the granitoids at Okeho within Southwestern Nigeria using geochemical data and assessing their potential for REE enrichment. Ten representative rock samples of the Proterozoic intrusives, syenite and granodiorite, were studied for their mineralogical and elemental compositions. Elemental concentrations were analysed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
Average major oxide concentrations revealed SiO2 (57.53 wt. %), Al2O3 (13.25 wt. %), CaO (5.05 wt. %), and MgO (5.59 wt. %) for the syenite and SiO2 (62.39 wt. %), Al2O3 (14.98 wt. %), CaO (3.67 wt. %), and MgO (3.25 wt. %) for the granodiorite. Total Alkali–Silica (TAS), Aluminum Saturation Index (ASI), and La/10-Y/15-Nb/8 plots discriminated the granitoids as metaluminous monzonite-syenite and peraluminous diorite-granodiorite. Average total REE concentrations in the syenite (625.06 ppm) and porphyritic-granodiorite (364.51 ppm) were above values reported for the granites in some mines in Jiangxi Province, Southern China.
Laju degradasi limbah masker medis surgical dengan menggunakan tingkatan instar larva Tenebrio molitor yang berbeda
Authors: Yunisa S Tri Alma , Gesriantuti Novia , Herlina Nofripa 
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui kemampuan larva T. molitor pada tingkatan instar 4, 6 dan 8 dalam mendegradasi limbah masker medis surgical yang dicampur ampas tahu dan dedak padi serta melihat pertambahan bobot badan larva. Penelitian ini dilakukan secara eksperimen menggunakan Metode Rancangan Acak Lengkap Faktorial (RALF) dengan 3 perlakuan dan 3 kali penggulangan masing-masing instar. Hasil dari penelitian ini menunjukkan bahwa Larva T. molitor pada instar 6 memiliki laju degradasi tertinggi yaitu 2,39 gr/hari dibandingkan instar 4 dan instar 8 dengan pakan masker yang dicampur dengan ampas tahu (P1). Sedangkan untuk laju degradasi terendah yaitu pada instar 4 yaitu sebesar 0,01 gr/hari, dengan pakan masker tanpa dicampur limbah organik. Pemberian pakan kombinasi pada larva menyebabkan perubahan yang signifikan terhadap bobot badan larva. Hubungan pakan yang terdegradasi dengan pertambahan bobot badan pada instar 4 dikategorikan sedang yaitu memiliki nilai korelasi (r) = 0,579 gr/hari dan instar 6 dikategorikan sedang juga karena memiliki nilai korelasi (r) = 0,509 gr/hari,sedangkan instar 8 memiliki korelasi (r) = 0,221 gr/hari dikatakan lemah dan tidak berpengaruh terhadap pertambahan bobot badan.
EXPEDIENCY OF USING ENZYME PREPARATIONS IN THE PRODUCTION OF PICKETS FOR GRAPE DISTILLATES
Authors: БАХМЕТОВ Р.Н. , ШЕЛУДЬКО О.Н. 
Published: July 2023

Наиболее доступный для винодельческих предприятий способ переработки виноградных выжимок – получение пикета с последующей его дистилляцией. Пектолитические ферментные препараты в виноделии в основ- ном используют при обработке виноградных сусел и мезги для повышения качества вин. В лабораторных условиях проведена оценка возможности применения пектолитического ферментного препарата Depectil Clarification для об- работки свежей сладкой выжимки. В качестве объектов исследования использовали образцы пикетов, полученные из сладкой виноградной выжимки столового белоягодного винограда сорта Илья урожая 2021 года, произрастаю- щего в коллекции ВНИИВиВ. Образец 1 готовили путем сбраживания пикета без добавления ферментного препа- рата пектолитического действия (контроль), образец 2 сбраживали с добавлением ферментного препарата. Выявле- на положительная динамика физико-химических и органолептических показателей пикета с добавкой ферментного препаратапектолитического действия по сравнению с контролем. Использование ферментного препарата позволило увеличить выход жидкой фракции пикета на 6%, ее прозрачность, сохранить цвет без оттенков, свойственных про- дуктам окисления, повысить объемную долю этилового спирта на 1,4% об., что доказывает возможность рассматри- вать нереализованную продукцию из винограда столовых сортовкак сырье для получения виноградных дистиллятов.
The most affordable way for wineries to process grape pomace is to obtain a picket with its subsequent distillation. Pectolytic enzymepreparations in winemaking are mainly used in the processing of grape pomace and pulp to improve the quality of wines. In laboratoryconditions, the possibility of using the pectolytic enzyme preparation Depectil Clarification for processing fresh sweet pomace was evaluated. The objects of the study were samples of pickets obtained from the sweet grape pomace of table white grapes of the Ilya variety of the harvest of 2021, growing in the All- Russian Research Institute for Viticulture and Winemaking collection. Sample 1 was prepared by fermentation of picket without the addition of an enzyme preparation of pectolytic action (control), sample 2 was fermented with the addition of an enzyme preparation. The positive dynamics of the physico-chemical and organoleptic parameters of the picket with the addition of an enzyme preparation of pectolytic action compared with the control was revealed. The use of an enzyme preparation made it possible to increase the yield of the liquid fraction of the picket by 6%, its transparency, preserve the color without shades characteristic of oxidation products, increase the volume fraction of ethyl alcohol by 1,4% vol., which proves the possibility of considering unrealized products from table grapes as raw materials for obtaining grape distillates.
INFLUENCE OF EXTRACTION CONDITIONS ON THE EXTRACTION OFBIOLOGICALLY ACTIVE COMPONENTS FROM PLANT RAW MATERIAL
Authors: ЕРЕМЕЕВА Н.Б. , ИВАНОВА В.А. 
Published: July 2023

Лекарственное растительное сырье имеет высокий потенциал для использования в производстве пище- вых продуктов засчет большого количества биологически активных веществ, которые обладают антиоксидантными свойствами. Для полного извлеченияданных веществ необходимо правильно подобрать параметры процесса экстра- гирования. Целью исследования является изучение химического состава и его зависимости от условий экстракции бадана корневищ, цветков василька синего, побегов черники, сеннылистьев и толокнянки листьев. Одним из ключе- вых параметров экстракции является выбранный растворитель и температура процесса. На основании эксперимен- тальных данных выбраны режимы процесса получения экстракта: экстрагирование 50%-ым этиловым спиртоммето- дом мацерации при температуре 40°C в течение 240 мин, гидромодуль 1 : 10. Антиоксидантные свойства оценивали по общему содержанию фенольных веществ (эквивалент галловой кислоты) и флавоноидов (эквивалент катехина). Наблюдалось высокое общее содержание фенольных веществ (ГК) и флавоноидов (К) в экстрактах толокнянки ли- стьев и сенны листьев – 1645 мг ГК/100 г ИС, 913 мг К/100 г ИС и 1844 мг ГК/100 г ИС, 596 мг К/100 г ИС соответ- ственно, в связи с чем их рекомендуется использовать в качествекомпонентов пищевых продуктов для придания им антиоксидантных свойств.
Medicinal plant materials have a high potential for use in food production due to the large number of biologically active substances that have antioxidant properties. For the complete extraction of these substances, it is necessary to correctly select the parameters of the extractionprocess. The aim of the study is to study the chemical composition and its dependence on the extraction conditions of bergenia rhizomes, blue cornflower flowers, blueberry shoots, senna leaves and bearberry leaves. One of the key extraction parameters is the chosen solvent and process temperature. Based on the experimental data, the modes of the extract preparation process were selected: extraction with 50% ethyl alcohol by maceration at a temperature of 40°C for 240 min, hydromodulus 1 : 10. Antioxidant properties were evaluated by the total content of phenolic substances (gallic acid equivalent) and flavonoids (catechin equivalent). A high total content of phenolic substances (GA) and flavonoids (C) wasobserved in extracts of bearberry leaves and senna leaves – 1645 mg GA / 100 g Feedstock, 913 mg C / 100 g Feedstock and 1844 mg GA / 100 g Feedstock, 596 mg C / 100 g Feedstock, respectively, in connection with which they are recommended to be used as components of food productsto give them antioxidant properties.
TECHNOLOGY OF PREPARATION OF TOMATO PUMP USING PHYSICAL METHODS TO EXTRACT CAROTENOIDS
Authors: ЛИСОВАЯ Е.В. , ВИКТОРОВА Е.П. , СВЕРДЛИЧЕНКО А.В. , ЖАНЕ М.Р. , ВЕЛИКАНОВА Е.В. , УГРЮМОВА Т.И. 
Published: July 2023

Выжимки томатов – перспективный источник получения каротиноидов. Как правило, извлечение бе- та-каротина и ликопина осуществляют экстракцией органическим растворителем, однако для повышения выхода целевых компонентов в экстракт необходимо проводить предварительную подготовку выжимок томатов. Цель ис- следования – изучение влияния физических методов предварительной подготовки выжимок томатов на эффектив- ность извлечения бета-каротина и ликопина. Определена эффективность обработки выжимок томатов ЭМП СВЧ, обеспечивающей переход содержащейся в них связанной воды в свободную, при этоммаксимальный эффект отмечен при темпе нагрева 1°С/с до достижения температуры 45°С. Продолжительность ИК-сушки выжимок томатов, пред- варительно обработанных ЭМП СВЧ, сократилась в 1,3 раза по сравнению с необработанными, при этом потери каротиноидов минимальны: 5,2 и 6,1% бета-каротина и ликопина соответственно по отношению к исходному со- держанию. Выявлено, что степень измельчения высушенных выжимок томатов, характеризуемая размером частиц 1 мм, обеспечивает максимальную эффективность извлечения бета-каротина и ликопина. Установлена эффектив- ность применения физических методов подготовки выжимок томатов, включая их обработку ЭМП СВЧ, последу- ющую ИК-сушку и измельчение, для получения комплекса каротиноидов, обеспечивающая максимальную степень извлечения бета-каротина и ликопина при последующей экстракции подготовленных выжимок томатов ацетоном.
Tomato pomace is a promising source of carotenoids. As a rule, the extraction of beta-carotene and lycopene is carried out by extraction with an organic solvent, however, to increase the yield of target components in the extract, it is necessary to pre-treat tomato pomace. The purpose of the study is to study the effect of physical methods of preliminary preparation of tomato pomace on the efficiency of beta-carotene and lycopene extraction. The efficiency of processing tomato pomace with EMF microwave, which ensures the transition of the bound water contained inthem into free water, was determined, while the maximum effect was noted at a heating rate of 1°C/s until a temperature of 45°C was reached. The duration of IR drying of tomato pomace, pre-treated with microwave EMF, decreased by 1,3 times compared to untreated, while the loss ofcarotenoids is minimal: 5,2 and 6,1% of beta-carotene and lycopene, respectively, relative to the initial content. It was revealed that thedegree of grinding of dried tomato pomace, characterized by a particle size of 1 mm, ensures the maximum efficiency of extraction of beta-carotene and lycopene. The effectiveness of the use of physical methods for the preparation of tomato pomace, including their processing withmicrowave EMF, subsequent IR drying and grinding, to obtain a complex of carotenoids, providing the maximum degree of extraction ofbeta- carotene and lycopene during the subsequent extraction of prepared tomato pomace with acetone, has been established.