bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volcanic and Tectonic Sources of Seismicity Near the Tanaga Volcanic Cluster, Alaska
Authors: Lally Kevin F. , Caplan‐Auerbach Jacqueline , Power John A. 
Published: June 2023

AbstractTanaga Island in the Central Aleutian Islands includes four stratovolcanoes: Sajaka, Tanaga, and East Tanaga in the northwest, and Takawangha in the central part of the island. Of these volcanoes, only Tanaga has a confirmed record of historical eruptive activity. We use double‐difference methods to relocate Tanaga Island earthquakes from the period 2003–2017 to gain insight into volcanic and tectonic activity in the region. High precision relative relocations show subsurface structures in the Tanaga region related to volcanism and crustal tectonics. In 2005, a swarm of ∼600 volcano‐tectonic events located below the NW portion of the island culminated with an episode of volcanic tremor. Although there was no known eruption associated with this swarm, we suggest that this activity is associated with fluids beneath Takawangha volcano. Overall, relatively little seismicity appears to be associated with volcanism: of 5,680 earthquakes relocated in this study, only ∼700 took place within 10 km of the volcanoes themselves. Other regions appear to experience primarily, if not exclusively, tectonic seismicity. Two regions on Tanaga Island became seismically active following a M6.6 tectonic earthquake east of the island on 2 May 2008, suggesting the triggering of tectonic earthquakes by the M6.6. Seismic activity recorded offshore and below the southern part of the island is interpreted as due to the clockwise rotation of the Delarof Block in the forearc, and bookshelf faulting along the volcanic arc. This suggests a complex pattern of earthquake hypocenters governed by both volcanic and tectonic processes surrounding Tanaga and Takawangha volcanoes.
Biomechanical control of lymphatic vessel physiology and functions
Authors: Angeli Veronique , Lim Hwee Ying 
Published: June 2023

AbstractThe ever-growing research on lymphatic biology has clearly identified lymphatic vessels as key players that maintain human health through their functional roles in tissue fluid homeostasis, immunosurveillance, lipid metabolism and inflammation. It is therefore not surprising that the list of human diseases associated with lymphatic malfunctions has grown larger, including issues beyond lymphedema, a pathology traditionally associated with lymphatic drainage insufficiency. Thus, the discovery of factors and pathways that can promote optimal lymphatic functions may offer new therapeutic options. Accumulating evidence indicates that aside from biochemical factors, biomechanical signals also regulate lymphatic vessel expansion and functions postnatally. Here, we review how mechanical forces induced by fluid shear stress affect the behavior and functions of lymphatic vessels and the mechanisms lymphatic vessels employ to sense and transduce these mechanical cues into biological signals.
Uncertainty in non-CO2 greenhouse gas mitigation contributes to ambiguity in global climate policy feasibility
Authors: Harmsen Mathijs , Tabak Charlotte , Höglund-Isaksson Lena , Humpenöder Florian , Purohit Pallav , van Vuuren Detlef 
Published: June 2023

AbstractDespite its projected crucial role in stringent, future global climate policy, non-CO2greenhouse gas (NCGG) mitigation remains a large uncertain factor in climate research. A revision of the estimated mitigation potential has implications for the feasibility of global climate policy to reach the Paris Agreement climate goals. Here, we provide a systematic bottom-up estimate of the total uncertainty in NCGG mitigation, by developing ‘optimistic’, ‘default’ and ‘pessimistic’ long-term NCGG marginal abatement cost (MAC) curves, based on a comprehensive literature review of mitigation options. The global 1.5-degree climate target is found to be out of reach under pessimistic MAC assumptions, as is the 2-degree target under high emission assumptions. In a 2-degree scenario, MAC uncertainty translates into a large projected range in relative NCGG reduction (40–58%), carbon budget (±120 Gt CO2) and policy costs (±16%). Partly, the MAC uncertainty signifies a gap that could be bridged by human efforts, but largely it indicates uncertainty in technical limitations.
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging
Authors: Feng Xu , Wang Liwen , Zhou Ruoyu , Zhou Rui , Chen Linyun , Peng Hui , Huang Yan , Guo Qi , Luo Xianghang , Zhou Haiyan 
Published: June 2023

AbstractBrown adipose tissue (BAT)-mediated thermogenesis declines with age. However, the underlying mechanism remains unclear. Here we reveal that bone marrow-derived pro-inflammatory and senescent S100A8+ immune cells, mainly T cells and neutrophils, invade the BAT of male rats and mice during aging. These S100A8+ immune cells, coupled with adipocytes and sympathetic nerves, compromise axonal networks. Mechanistically, these senescent immune cells secrete abundant S100A8 to inhibit adipose RNA-binding motif protein 3 expression. This downregulation results in the dysregulation of axon guidance-related genes, leading to impaired sympathetic innervation and thermogenic function. Xenotransplantation experiments show that human S100A8+ immune cells infiltrate mice BAT and are sufficient to induce aging-like BAT dysfunction. Notably, treatment with S100A8 inhibitor paquinimod rejuvenates BAT axon networks and thermogenic function in aged male mice. Our study suggests that targeting the bone marrow-derived senescent immune cells presents an avenue to improve BAT aging and related metabolic disorders.
M1BP is an essential transcriptional activator of oxidative metabolism during Drosophila development
Authors: Poliacikova Gabriela , Barthez Marine , Rival Thomas , Aouane Aïcha , Luis Nuno Miguel , Richard Fabrice , Daian Fabrice , Brouilly Nicolas , Schnorrer Frank , Maurel-Zaffran Corinne , Graba Yacine , Saurin Andrew J. 
Published: June 2023

AbstractOxidative metabolism is the predominant energy source for aerobic muscle contraction in adult animals. How the cellular and molecular components that support aerobic muscle physiology are put in place during development through their transcriptional regulation is not well understood. Using the Drosophila flight muscle model, we show that the formation of mitochondria cristae harbouring the respiratory chain is concomitant with a large-scale transcriptional upregulation of genes linked with oxidative phosphorylation (OXPHOS) during specific stages of flight muscle development. We further demonstrate using high-resolution imaging, transcriptomic and biochemical analyses that Motif-1-binding protein (M1BP) transcriptionally regulates the expression of genes encoding critical components for OXPHOS complex assembly and integrity. In the absence of M1BP function, the quantity of assembled mitochondrial respiratory complexes is reduced and OXPHOS proteins aggregate in the mitochondrial matrix, triggering a strong protein quality control response. This results in isolation of the aggregate from the rest of the matrix by multiple layers of the inner mitochondrial membrane, representing a previously undocumented mitochondrial stress response mechanism. Together, this study provides mechanistic insight into the transcriptional regulation of oxidative metabolism during Drosophila development and identifies M1BP as a critical player in this process.
Large anomalies in future extreme precipitation sensitivity driven by atmospheric dynamics
Authors: Gu Lei , Yin Jiabo , Gentine Pierre , Wang Hui-Min , Slater Louise J. , Sullivan Sylvia C. , Chen Jie , Zscheischler Jakob , Guo Shenglian 
Published: June 2023

AbstractIncreasing atmospheric moisture content is expected to intensify precipitation extremes under climate warming. However, extreme precipitation sensitivity (EPS) to temperature is complicated by the presence of reduced or hook-shaped scaling, and the underlying physical mechanisms remain unclear. Here, by using atmospheric reanalysis and climate model projections, we propose a physical decomposition of EPS into thermodynamic and dynamic components (i.e., the effects of atmospheric moisture and vertical ascent velocity) at a global scale in both historical and future climates. Unlike previous expectations, we find that thermodynamics do not always contribute to precipitation intensification, with the lapse rate effect and the pressure component partly offsetting positive EPS. Large anomalies in future EPS projections (with lower and upper quartiles of −1.9%/°C and 8.0%/°C) are caused by changes in updraft strength (i.e., the dynamic component), with a contrast of positive anomalies over oceans and negative anomalies over land areas. These findings reveal counteracting effects of atmospheric thermodynamics and dynamics on EPS, and underscore the importance of understanding precipitation extremes by decomposing thermodynamic effects into more detailed terms.
Clinical outcomes in estrogen receptor-positive early-stage breast cancer patients with Recurrence Score 26-30: observational real-world cohort study
Authors: Rotem Ofer , Peretz Idit , Leviov Michelle , Kuchuk Iryna , Itay Amit , Tokar Margarita , Paluch-Shimon Shani , Maimon Ofra , Yerushalmi Rinat , Drumea Karen , Evron Ella , Sonnenblick Amir , Gal-Yam Einav , Goldvaser Hadar , Samih Yosef , Merose Rotem , Bareket-Samish Avital , Soussan-Gutman Lior , Stemmer Salomon M. 
Published: June 2023

AbstractData on adjuvant chemotherapy (CT) benefit in ER + HER2‒ early-stage breast cancer (EBC) patients with Recurrence Score (RS) 26-30 are limited. This real-world study evaluated the relationships between the RS, adjuvant treatments, and outcomes in 534 RS 26-30 patients tested through Clalit Health Services (N0: n = 394, 49% CT-treated; N1mi/N1: n = 140, 62% CT-treated). The CT-treated and untreated groups were imbalanced (more high-risk clinicopathologic characteristics in CT-treated patients). With median follow-up of 8 years, Kaplan–Meier estimates for overall survival (OS), distant recurrence-free survival (DRFS), and BC-specific mortality (BCSM) were not significantly different between CT-treated and untreated N0 patients. Seven-year rates (95% CI) in CT-treated vs untreated: OS, 97.9% (94.4–99.2%) vs 97.9% (94.6–99.2%); DRFS, 91.5% (86.6–94.7%) vs 91.2% (86.0–94.6%); BCSM, 0.5% (0.1–3.7%) vs 1.6% (0.5–4.7%). For N1mi/N1 patients, OS/DRFS did not differ significantly between treatment groups; whereas BCSM did (1.3% [0.2–8.6%] vs 6.2% [2.0–17.7%] for CT-treated and untreated patients, respectively, p = 0.024).
Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen
Authors: Zhan Yixiang , Ni Kemin , Liu Zhaoce , xin Ran , Han Qiurong , Ping Hangyu , Liu Yaohong , Zhao Xuanzhu , Wang Wanting , Yan Suying , Sun Jing , Zhang Qinghuai , Wang Guihua , Zhang Zili , Zhang Xipeng , Hu Xia , Li Guoxun , Zhang Chunze 
Published: June 2023

AbstractWe evaluate the prognostic value of chemotherapy and other prognostic factors on overall survival among colon patients with deficient mismatch repair (dMMR), and determine the optimum time to start chemotherapy after surgery. Data of 306 colon cancer patients with dMMR who received radical surgery were collected from three Chinese centers between August 2012 and January 2018. Overall survival (OS) was assessed with the Kaplan–Meier method and log-rank. Cox regression analysis were used to assess influencing prognosis factors. The median follow-up time for all patients was 45.0 months (range, 1.0–100). There was a nonsignificant OS benefit from chemotherapy for patients with stage I and stage II disease, including high-risk stage II disease (log-rank p: 0.386, 0.779, 0.921), and a significant OS benefit for patients with stage III and stage IV disease for receiving post-operation chemotherapy (log-rank p = 0.002, 0.019). Stage III patients benefitted from chemotherapy regimens that contained oxaliplatin (log-rank p = 0.004), and Starting chemotherapy with oxaliplatin treatment earlier resulted in better outcomes (95% CI 0.013–0.857; p = 0.035). Chemotherapy regimens containing oxaliplatin can prolong the survival time of stage III and IV dMMR colon cancer patients. This beneficial manifestation was more pronounced after starting chemotherapy treatment early post operation. High risk stage II dMMR colon patients including T4N0M0 cannot benefit from chemotherapy.
DEM modeling direct shearing behavior of sand considering anti-rotation of particle
Authors: Wu Liming , Qian Jiangu , Xie Liangfu , Qin Yongjun 
Published: June 2023

AbstractConsidering anti-rotation of sand particles, two-dimensional Discrete Element Method (DEM) has been employed to reproduce direct shear behaviors of sand with different particle distribution sizes, so as to explore effects of anti-rotation of particle on responses of stress-displacement and dilatancy, the evolution law of shear stress, coordination number and vertical displacement of sand samples, and analyze the contact force chain, contact fabric and porosity of the samples after shearing.The results show that the anti-rotation ability of sand is enhanced, the torque of overcoming the relative rotation between particles is increased, and the peak shear stress, dilatancy and porosity in the middle of the sample are increased; with the increase of the anti-rotation coefficient, the coordination number decreases more obviously. The proportion of the contact number in the direction of 100°–160° to the total contact number decreases with the increase of the anti-rotation coefficient. The elliptical shape of the contact configuration becomes more flat, and the anisotropy of the contact force chain is more obvious; compared with fine sand, the coarse sand has greater shear capacity, more obvious dilatancy and larger porosity in the middle of the sample.The maximum minimum particle size ratio of the sample becomes larger, so that the shear strength of the sample is reduced, and the dilatancy is also weak.
Stimulus specific cortical activity associated with ignoring distraction during working memory encoding and maintenance
Authors: Ashton Charlotte , Gouws Andre D. , Glennon Marcus , Das Abhishek , Chen Yit-Keat , Chrisp Charlotte , Felek Ismail , Zanto Theodore P. , McNab Fiona 
Published: June 2023

AbstractDistraction disrupts Working Memory (WM) performance, but how the brain filters distraction is not known. One possibility is that neural activity associated with distractions is suppressed relative to a baseline/passive task (biased competition). Alternatively, distraction may be denied access to WM, with no suppression. Furthermore, behavioural work indicates separate mechanisms for ignoring distractions which occur (1) while we put information into WM (Encoding Distraction, ED) and (2) while we maintain already encoded information during the WM delay period (Delay Distraction, DD). Here we used fMRI in humans to measure category-sensitive cortical activity and probe the extent to which ED/DD mechanisms involve enhancement/suppression during a WM task. We observed significant enhancement of task-relevant activity, relative to a passive view task, which did not differ according to whether or when distractors appeared. For both ED and DD we found no evidence of suppression, but instead a robust increase in stimulus specific activity in response to additional stimuli presented during the passive view task, which was not seen for the WM task, when those additional stimuli were to be ignored. The results indicate that ED/DD resistance does not necessarily involve suppression of distractor-related activity. Rather, a rise in distractor-associated activity is prevented when distractors are presented, supporting models of input gating, and providing a potential mechanism by which input-gating might be achieved.
Kinematics and energetics of foraging behavior in Rice’s whales of the Gulf of Mexico
Authors: Kok Annebelle C. M. , Hildebrand Maya J. , MacArdle Maria , Martinez Anthony , Garrison Lance P. , Soldevilla Melissa S. , Hildebrand John A. 
Published: June 2023

AbstractRorqual foraging behavior varies with species, prey type and foraging conditions, and can be a determining factor for their fitness. Little is known about the foraging ecology of Rice’s whales (Balaenoptera ricei), an endangered species with a population of fewer than 100 individuals. Suction cup tags were attached to two Rice’s whales to collect information on their diving kinematics and foraging behavior. The tagged whales primarily exhibited lunge-feeding near the sea bottom and to a lesser extent in the water-column and at the sea surface. During 6–10 min foraging dives, the whales typically circled their prey before executing one or two feeding lunges. Longer duration dives and dives with more feeding-lunges were followed by an increase in their breathing rate. The median lunge rate of one lunge per dive of both animals was much lower than expected based on comparative research on other lunge-feeding baleen whales, and may be associated with foraging on fish instead of krill or may be an indication of different foraging conditions. Both animals spent extended periods of the night near the sea surface, increasing the risk for ship strike. Furthermore, their circling before lunging may increase the risk for entanglement in bottom-longline fishing gear. Overall, these data show that Rice’s whale foraging behavior differs from other lunge feeding rorqual species and may be a significant factor in shaping our understanding of their foraging ecology. Efforts to mitigate threats to Rice’s whales will benefit from improved understanding of patterns in their habitat use and fine-scale ecology.
Importance of depth and temperature variability as drivers of coral symbiont composition despite a mass bleaching event
Authors: de Souza Mariana Rocha , Caruso Carlo , Ruiz-Jones Lupita , Drury Crawford , Gates Ruth D. , Toonen Robert J. 
Published: June 2023

AbstractCoral reefs are iconic examples of climate change impacts because climate-induced heat stress causes the breakdown of the coral-algal symbiosis leading to a spectacular loss of color, termed ‘coral bleaching’. To examine the fine-scale dynamics of this process, we re-sampled 600 individually marked Montipora capitata colonies from across Kāne’ohe Bay, Hawai’i and compared the algal symbiont composition before and after the 2019 bleaching event. The relative proportion of the heat-tolerant symbiont Durusdinium in corals increased in most parts of the bay following the bleaching event. Despite this widespread increase in abundance of Durusdinium, the overall algal symbiont community composition was largely unchanged, and hydrodynamically defined regions of the bay retained their distinct pre-bleaching compositions. We explain ~ 21% of the total variation, of which depth and temperature variability were the most significant environmental drivers of Symbiodiniaceae community composition by site regardless of bleaching intensity or change in relative proportion of Durusdinium. We hypothesize that the plasticity of symbiont composition in corals may be constrained to adaptively match the long-term environmental conditions surrounding the holobiont, despite an individual coral’s stress and bleaching response.
Performance evolution of prestressing anchor bars in corrosive environments experimental study
Authors: Liu Dandan , Chen An 
Published: June 2023

AbstractIn order to explore the performance evolution of prestressed anchor cables in corrosive environment, the corrosion immersion and corrosion damage performance tests of prestressed anchor bars in corrosive environment were carried out indoors. Based on the experimental results, the effects of stress level, pH and time on the corrosion process of prestressing anchor bars, the amount of corrosion per unit length and the change of mechanical properties were analyzed. It was found that the greater the stress level in the three corrosive media, the more severe the corrosion of the anchor bars, especially in acidic solutions; at the beginning of corrosion, prestressing anchor bars corrode fastest in neutral solution, followed by acidic and slowest in alkaline, with the continuation of corrosion, the degree of corrosion damage to anchor bars by acidic solution is more obvious; The corrosion damage of anchor tendons reflected by the corrosion amount per unit length is uniform corrosion, and local corrosion will aggravate the degree of corrosion damage of prestressing anchor tendons; The longer the corrosion time, the more serious the corrosion of anchor bars, and the 2 mechanical indexes of anchor bar elongation and fracture load have a significant decreasing trend.
Preparation and evaluation of some nanocarbon (NC) based composites for optoelectronic applications
Authors: Elhalawany Noha , Abdel-karim Amal M. , Saleeb Maher M. 
Published: June 2023

AbstractPolyaniline/nanocarbon (PANI/NC) nanocomposites have been prepared by in situ polymerization of aniline monomer in the presence of a stable colloidal solution of nanocarbon NC using ammonium persulfate as an initiator and silver ions (Ag+) as oxidizing agents to produce PANI/NC and PANI/NC/Ag2O nanocomposites, respectively. The morphological studies of the formed nanocomposites have been elucidated via transmission and scanning electron microscopes (TEM and SEM). Further characterization of the prepared nanocomposites has been done via infrared spectroscopy (IR), X-ray diffractometer (XRD), X-ray photoelectron spectroscopy (XPS), particle size distribution analysis (PSD), fluorescence microscope (FM), UV–VIS spectroscopy, and finally surface analysis. XRD results confirmed the presence of silver oxide Ag2O nanoparticles, and the obtained data is well matched with the JCPDS card number 76–1393 of silver oxide. XPS analyses have shown two prevailing characteristic peaks for Ag 3d5/2 and Ag 3d3/2 at 367.1 and 373 eV, respectively, representing Ag2O nanoparticles, which are matchable with the XRD analysis. The PSD analysis revealed that the sizes of the prepared nanocomposites are in the size range from 60 to 140 nm. The FM measurements showed luminescence from the prepared nanocomposites upon irradiation with different lights. This recommends that the fluorophores present in the prepared nanocomposites have the potential to both absorb and emit light. The AC conductivity and the dielectric permittivity of the obtained nanocomposites at room temperature and at different frequency ranges have been investigated. At higher frequency ranges, the maximum ac conductivity obtained was 1.06 × 10–2 and 2.5 × 10–2 S.Cm-1 for the PANI/NC and PANI/NC/Ag2O, respectively. As far as we know, these new nanocomposites with superior optical and electrical characteristics have not been described yet in the literature.