bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different choline supplement metabolism in adults using deuterium labelling
Authors: Böckmann Katrin A. , Franz Axel R. , Shunova Anna , Minarski Michaela , Wiechers Cornelia , Poets Christian F. , Bernhard Wolfgang 
Published: February 2023

Abstract
Background
Choline deficiency leads to pathologies particularly of the liver, brain and lung. Adequate supply is important for preterm infants and patients with cystic fibrosis. We analysed the assimilation of four different enterally administered deuterium-labelled (D9-) choline supplements in adults.

Methods
Prospective randomised cross-over study (11/2020–1/2022) in six healthy men, receiving four single doses of 2.7 mg/kg D9-choline equivalent each in the form of D9-choline chloride, D9-phosphorylcholine, D9-alpha-glycerophosphocholine (D9-GPC) or D9-1-palmitoyl-2-oleoyl-glycero-3-phosphoryl-choline (D9-POPC), in randomised order 6 weeks apart. Plasma was obtained at baseline (t = − 0.1 h) and at 0.5 h to 7d after intake. Concentrations of D9-choline and its D9-labelled metabolites were analysed by tandem mass spectrometry. Results are shown as median and interquartile range.

Results
Maximum D9-choline and D9-betaine concentrations were reached latest after D9-POPC administration versus other components. D9-POPC and D9-phosphorylcholine resulted in lower D9-trimethylamine (D9-TMAO) formation. The AUCs (0-7d) of plasma D9-PC concentration showed highest values after administration of D9-POPC. D9-POPC appeared in plasma after fatty acid remodelling, predominantly as D9-1-palmitoyl-2-linoleyl-PC (D9-PLPC), confirming cleavage to 1-palmitoyl-lyso-D9-PC and re-acylation with linoleic acid as the most prominent alimentary unsaturated fatty acid.

Conclusion
There was a delayed increase in plasma D9-choline and D9-betaine after D9-POPC administration, with no differences in AUC over time. D9-POPC resulted in a higher AUC of D9-PC and virtually absent D9-TMAO levels. D9-POPC is remodelled according to enterocytic fatty acid availability. D9-POPC seems best suited as choline supplement to increase plasma PC concentrations, with PC as a carrier of choline and targeted fatty acid supply as required by organs. This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498, 22.01.2020.

Study registration
This study was registered at Deutsches Register Klinischer Studien (DRKS) (German Register for Clinical Studies), DRKS00020498.
Psoas abscess in pregnancy: a review of the literature and suggestion of minimally invasive treatment options
Authors: Schröder Carolin , Calite Elina , Böckenhoff Paul , Büttner Thomas , Stein Johannes , Gembruch Ulrich , Strizek Brigitte 
Published: February 2023

Abstract
Aim
Less than a dozen cases of psoas abscesses in pregnancy have been described in the literature. We reviewed the literature when treating a patient with a psoas abscess after ipsilateral double J-ureteral stent placement (in the following: “double J-stent”) due to infected hydronephrosis.

Methods
In January 2022, this review was searched using the Pubmed/MEDLINE database and the mesh terms “Psoas Abscess” AND “Pregnancy”. Studies were included in any language and of all years, describing a psoas abscess during pregnancy. When patients did not have a psoas abscess, the abscess occurred after pregnancy, or when there was no full text available, the article was excluded.

Main results
Ten case reports about patients with psoas abscesses during pregnancy were included. The classical symptomatic triad of psoas muscle abscess included lower back pain, limping and persistent fever with daily spikes. However, in most cases, not all three symptoms can be found. Especially, fever is absent in more than half of the patients. Psoas abscesses are described between 13 and 39 weeks of gestation. Primary psoas abscesses with haematogenous spread are more common during pregnancy than secondary with spread per continuitatem. In the literature, the main reasons for psoas abscess are spinal tuberculosis, drug abuse or underlying diseases such as Crohn’s disease. It is not uncommon for the definite cause to be unclear. Regarding the patient's symptoms, pyelonephritis is often considered a possible aetiology. In general, the main treatment options include antibiotic treatment and abscess drainage. There is no higher caesarean section rate, and no negative outcome for the foetus has been described.

Case presentation
In our patient, a 38-year-old obese Caucasian woman, who had received a left double J-stent for infected hydronephrosis at 15 weeks of gestation, we successfully treated a psoas abscess of 20 × 10 cm with a sonographically assisted abscess drainage and antibiotics. The further course of pregnancy and the elective repeat caesarean section at 38 + 0 weeks of gestation were without any problems. Double J-stent placement and laser stone lithotripsy during puerperium were performed because of recurrent urolithiasis.

Conclusions
Although rare, psoas abscesses can occur during pregnancy, and it has often been treated surgically in the past. A psoas abscess as a complication after infected hydronephrosis and intervention during pregnancy has never been reported in the literature. Even for obese patients, minimally invasive therapy may be a treatment option that has rarely been reported in the literature.
Comparing structural models of linear elastic responses to bending in inosculated joints
Authors: Middleton Wilfrid , Erdal Halil Ibrahim , Detter Andreas , D’Acunto Pierluigi , Ludwig Ferdinand 
Published: February 2023

Abstract
Key message
Mechanical models of inosculations benefit from moderate geometric detail and characterisation of the structurally optimised area of interwoven tension-resistant fibres between the branches.

Abstract
Living architecture is formed by shaping and merging trees, often in combination with non-living technical elements. These structures often employ the mechanical and physiological adaptations of living trees to support structural loads. Designed and vernacular buildings utilise inosculations to redistribute forces, redirect growth, and provide redundancy. Mechanical models of inosculations in living architecture must be built according to the adaptations available to the tree. Here, mass allocation and fibre orientation are examined. Under typical gravity loads, a zone at the top of the inosculation is subject to tension. This is of particular interest because a trade-off in fibre orientation between mechanical and physiological optimisation is necessary. In tree forks, this results in specifically adapted interwoven fibres. In this study, Finite Element Analysis (FEA) is used to develop different mechanical models to fit bending experiments of four Salix alba inosculations, comparing the models’ accuracy in replicating rotations in the joint. Nine models were developed. Three levels of detail of mass allocation are considered for global isotropic (3 models) and orthotropic (3 models) mechanical properties as well as a model including the interwoven tension zone, a model of local branch and trunk orthotropy, and a model combining these two localised features. Results show significant accuracy gains come from moderate geometric accuracy and consideration of the tension-zone optimisation. The construction of the tension zone in FEA is simple and applicable to natural and artificially induced inosculations.
Grenzsituationen als Potenzial
Authors: Karis Sonja 
Published: February 2023

ZusammenfassungDer Sezierkurs stellt eine wesentliche Etappe in der medizinischen Ausbildung dar. Psychoemotionale Eindrücke der teilnehmenden Student:innen sowie protektive Faktoren wurden von Studierenden der Karl Landsteiner Universität in Kursprotokollen dokumentiert. Im Rahmen einer qualitativen Inhaltsanalyse wurden deren Inhalte ausgewertet. Über die klinische Anwendbarkeit der Ergebnisse wird anhand von exemplarischen Protokolleinträgen berichtet.
Evaluation of Ficus nitida Allelopathic Potential and the Most Efficient Application Method for Controlling Weeds Associated with Sunflower Plant
Authors: El–Wakeel Mona Adel , Ahmed Salah El-Din Abd El-Ghany Ahmed , Messiha Nadia Khalil 
Published: February 2023

AbstractAllelopathy is a phenomenon by which plants positively or negatively affect neighboring plants by releasing allelopathic compounds. These allelochemicals are secondary metabolites found in different concentrations in shoots, roots, leaves, flowers, and even pollen grains. Allelochemicals have potential as natural bioherbicides for controlling weeds when applied in the form of extracts or through intercropping, cover cropping, and mulching. The present study was conducted to investigate the allelopathic potential of Ficus nitida leaves against Echinochloa crus-galli L. and Corchorus olitorius L weeds associated with sunflower plant via two application methods (mixing of F. nitida leaf powder with soil and foliar spray of F. nitida leaf powder alcoholic extract). Two pot experiments were carried out for the two summer seasons of 2020 and 2021 in the greenhouse of the National Research Centre (NRC), Dokki, Giza, Egypt. Nine treatments were applied in a completely randomized block design. Three treatments were applied before sowing, namely F. nitida leaf powder was mixed with the soil at rates of 15, 30, and 45 g/pot. The other three treatments of alcoholic leaf powder extract of F. nitida were sprayed twice on both plants and weeds at 10, 20, and 30% (w/v) concentrations. Additionally, three check treatments—healthy (sunflower only), unweeded, and both weeds only—were applied for comparison. The recorded results showed that F. nitida had an allelopathic bioherbicidal effect on both weeds. By increasing the concentration of F. nitida extract, the bioherbicidal potential increased. Moreover, the recorded results showed that foliar spray of alcoholic extract at 30% concentration was the superior application method for controlling weeds. Mixing of F. nitida leaf powder at 45 g/pot ranked second after this superior treatment. A noticeable result is that these two superior treatments improved sunflower growth parameters and yield traits. Quantitative estimation of phenolic compounds and flavonoids demonstrated that the concentration of these allelochemicals is higher in alcoholic extract than in water extract. Moreover, phenolic acid concentrations as detected by high-performance liquid chromatography fractionation are higher in alcoholic extract than in water extract.
Prioritizing rural populations in state comprehensive cancer control plans: a qualitative assessment
Authors: Hirschey Rachel , Rohweder Catherine , Zahnd Whitney E. , Eberth Jan M. , Adsul Prajakta , Guan Yue , Yeager Katherine A. , Haines Heidi , Farris Paige E. , Bea Jennifer W. , Dwyer Andrea , Madhivanan Purnima , Ranganathan Radhika , Seaman Aaron T. , Vu Thuy , Wickersham Karen , Vu Maihan , Teal Randall , Giannone Kara , Hilton Alison , Cole Allison , Islam Jessica Y. , Askelson Natoshia 
Published: February 2023

Abstract
Purpose
The Centers for Disease Control and Prevention’s National Comprehensive Cancer Control Program (NCCCP) requires that states develop comprehensive cancer control (CCC) plans and recommends that disparities related to rural residence are addressed in these plans. The objective of this study was to explore rural partner engagement and describe effective strategies for incorporating a rural focus in CCC plans.

Methods
States were selected for inclusion using stratified sampling based on state rurality and region. State cancer control leaders were interviewed about facilitators and barriers to engaging rural partners and strategies for prioritizing rural populations. Content analysis was conducted to identify themes across states.

Results
Interviews (n = 30) revealed themes in three domains related to rural inclusion in CCC plans. The first domain (barriers) included (1) designing CCC plans to be broad, (2) defining “rural populations,” and (3) geographic distance. The second domain (successful strategies) included (1) collaborating with rural healthcare systems, (2) recruiting rural constituents, (3) leveraging rural community–academic partnerships, and (4) working jointly with Native nations. The third domain (strategies for future plan development) included (1) building relationships with rural communities, (2) engaging rural constituents in planning, (3) developing a better understanding of rural needs, and (4) considering resources for addressing rural disparities.

Conclusion
Significant relationship building with rural communities, resource provision, and successful strategies used by others may improve inclusion of rural needs in state comprehensive cancer control plans and ultimately help plan developers directly address rural cancer health disparities.
Fine-scale functional connectivity of two syntopic pond-breeding amphibians with contrasting life-history traits: an integrative assessment of direct and indirect estimates of dispersal
Authors: Martínez-Gil Helena , Sánchez-Montes Gregorio , Montes-Gavilán Pedro , Ugarte Gorka , Martínez-Solano Íñigo 
Published: February 2023

AbstractAssessing patterns of functional connectivity among amphibian demes is crucial to unravel their population dynamics and prevent their isolation and eventual extinction. Integrative studies based on direct (capture-mark-recapture) and indirect (genetic) estimates of dispersal provide robust, biologically realistic inferences on population structure and connectivity, with applications for conservation efforts. We focused on two pond-breeding amphibians with contrasting life-history traits: the short-lived, semi-arboreal Hyla molleri and the long-lived, fossorial Pelobates cultripes. We PIT-tagged 2150 individuals of both species in two ponds (Laguna and Gravera, separated by 700 m) and monitored them from 2009 to 2021 to document the frequency and spatial extent of dispersal events. In addition, we genotyped individuals from these and two additional breeding populations at a maximum distance of 5 km with 15–16 microsatellites to characterize fine-scale patterns of genetic structure. We detected dispersal events connecting Laguna and Gravera in both species, albeit at low frequencies (4.8% and 7.7% of recaptured individuals of H. molleri and P. cultripes, respectively). However, both species were capable of covering long distances, with individual accumulated displacements up to 3.5 km (Hyla) and 1.8 km (Pelobates). Breeding populations > 2 km apart were genetically differentiated, indicating lower connectivity at this spatial scale. Estimates of pairwise migration rates differed between species and were asymmetrical, with different ponds representing “source” populations contributing more migrants to other populations in each species. We discuss the role of differences in life history traits and ecological preferences in shaping population dynamics in the two species and highlight management implications of our results.
The Maltese single transferable vote experience: a case study of gerrymandering?
Authors: Hasancebi Serhat 
Published: February 2023

AbstractRe-drawing the electoral boundaries to provide benefit to one particular political party and thereby damaging the principle of representation in democracy has been a core issue in political science in the recent years. For years social scientists have been advocating the idea of measuring or preventing the potential for damage that may arise from the existence of the above-mentioned redistricting process. Following this discussion, we investigate the possible gerrymandering phenomenon that might have arisen, or whether there are any asymmetries or partisan biases due to boundary delimitation of the electoral constituencies in the case of the Maltese general elections. From the evidence of various statistical tests and simulations, our conclusion is that we find no evidence of gerrymandering in the 2013 and 2017 Maltese general elections.
Effects of the Prevention Program “HateLess. Together against Hatred” on Adolescents’ Empathy, Self-efficacy, and Countering Hate Speech
Authors: Wachs Sebastian , Krause Norman , Wright Michelle F. , Gámez-Guadix Manuel 
Published: February 2023

AbstractCurrently, there is a lack of empirically evaluated prevention programs targeting hate speech among adolescents. This is problematic because hate speech jeopardizes adolescents’ well-being and social integration. To this end, this study aims to evaluate the short-term effects of the newly developed anti-hate speech prevention program, “HateLess. Together against Hatred”, on adolescents’ empathy, self-efficacy, and counter-speech. Eight hundred and twenty adolescents between 12 and 16 (M = 13.27,SD = 1.04) from 11 German schools participated in this study. More specifically, 567 adolescents participated in the one-week prevention program, and 253 participants were assigned to the control group. Repeated measures ANOVAs showed that HateLess was successful, as there was a significant increase in empathy, self-efficacy, and counter-speech in the intervention group from the pretest (T1) to the posttest (T2) one month after the intervention. In contrast, no changes were found among adolescents in the control group. A multilevel mediation model revealed that the effect of being a member of the intervention group on counter-speech was partially mediated via empathy and self-efficacy. The findings indicate that HateLess is an effective, cost-efficient approach to enhance adolescents’ counter-speech directly and indirectly by altering the skills they need to become informed citizens in democratic societies.
Effect of poly (acrylamide-co-acrylic acid salt) on anti-aging properties and adhesion between acrylonitrile butadiene rubber and polyester fabric
Authors: Abdel‐Hakim Ahmed , El‐Wakil Abd El‐Aziz Arafa , Halim Sawsan 
Published: February 2023

AbstractIn this study, a multifunction polymeric adhesion promoter and anti-aging compound based on the triethanolamine salt of acrylamide acrylic acid copolymer (COS) was prepared and characterized using Fourier-transform infrared spectroscopy (FTIR). The impact of different COS contents on the tensile, adhesion, and thermal properties of NBR composite and NBR/PET sandwich was evaluated. The NBR composites containing COS displayed good retention of their mechanical properties with increasing thermal ageing time, while the composite without COS showed a decrease in its mechanical properties. The highest tensile strength (17.5 MPa with a retention value of 0.6%) after 7 days of thermal aging was recorded for NBR composite, which contains 5 phr (parts per hundred parts of rubber) of COS (COS 5), compared to NBR composite without COS (COS 0), which recorded 15.1 MPa with a retention value of -27.4%. In addition, the COS 5 composite displayed an improvement in peel strength of 16.4% compared to the COS 0. The results of the thermogarvemetric analysis (TGA) supported the anti-thermal ageing effect of COS, where the initial decomposition temperature (Ti) value increased by 11.7 and 9.3 °C, after addition of 5 and 10 phr of COS to NBR composite, respectively. In addition, the other thermogravemetric parameters investigated displayed a significant increase in their values, which confirms the improvement in thermal stability of NBR composite in the presence of COS. Also, the air permeability of the PET/NBR sandwich decreased by 80% after the addition of 7.5 phr of COS.
The multiomic landscape of meningiomas: a review and update
Authors: Wang Justin Z. , Nassiri Farshad , Landry Alexander P. , Patil Vikas , Liu Jeff , Aldape Kenneth , Gao Andrew , Zadeh Gelareh 
Published: February 2023

Abstract
Purpose
Meningiomas are the most common primary brain tumor in adults. Traditionally they have been understudied compared to other central nervous system (CNS) tumors. However over the last decade, there has been renewed interest in uncovering the molecular topography of these tumors, with landmark studies identifying key driver alterations contributing to meningioma development and progression. Recent work from several independent research groups have integrated different genomic and epigenomic platforms to develop a molecular-based classification scheme for meningiomas that could supersede histopathological grading in terms of diagnostic accuracy, biological relevance, and outcome prediction, keeping pace with contemporary grading schemes for other CNS tumors including gliomas and medulloblastomas.

Methods
Here we summarize the studies that have uncovered key alterations in meningiomas which builds towards the discovery of consensus molecular groups in meningiomas by integrating these findings. These groups supersede WHO grade and other clinical factors in being able to accurately predict tumor biology and clinical outcomes following surgery.

Results
Despite differences in the nomenclature of recently uncovered molecular groups across different studies, the biological similarities between these groups enables us to likely reconciliate these groups into four consensus molecular groups: two benign groups largely dichotomized by NF2-status, and two clinically aggressive groups defined by their hypermetabolic transcriptome, and by their preponderance of proliferative, cell-cycling pathways respectively.

Conclusion
Future work, including by our group and others are underway to validate these molecular groups and harmonize the nomenclature for routine clinical use.
Persistence and Structure
Authors: Sattig Thomas 
Published: February 2023

AbstractPerdurance is a mode of persistence. The heart of perdurance is a space-time analogy: a perduring object is extended in time in a way that is analogous to how a composite object is extended in space. This paper is a discussion of perdurance in light of the distinction between mereologically structured and unstructured objects. I show that while the standard formulation of perdurance captures the space-time analogy for unstructured objects, it fails to capture the space-time analogy for temporally and spatially structured objects. I conclude that there are substantially different ways for an object to be space-like temporally extended.
Factors influencing the perceived value of travel time in European urban areas
Authors: Pourhashem Ghadir , Georgouli Christina , Malichová Eva , Straka Milan , Kováčiková Tatiana 
Published: February 2023

AbstractThis research aims at expanding the scope of travel satisfaction by incorporating subjective elements in the evaluation of worthwhileness of travel time proposed by the H2020 MoTiV project, using a European-wide mobility dataset collected in 2019. Trip characteristics, mood, socio-demographic characteristics, experience factors, travel activities and weather were analysed to explore their influence on travellers’ perception of worthwhileness of travel time. The analysis was performed separately for five different transport mode categories using Structural Equation Models. The empirical analysis of this research indicates the high significance of enjoyment in terms of making a trip worthwhile for all transport modes. The results also revealed mode-specific experience factors that play an important role in shaping travel experience which could be addressed to improve the quality of travel time. It is expected that these results can support a shift towards a more human-centric approach in urban mobility plans as well as pave the way for more inclusive transport policies.