bluuebunny/crossref_metadata_2025_split huggingface dataset:
The meta-analysis of sister chromatid exchange as a biomarker in healthcare workers with occupational exposure to antineoplastic drugs
Authors: Hu Jinchen , Zhao Feifei , Liu Lin , Huang Hong , Huang Xiaohong 
Published: August 2023

Background:
Sister chromatid exchange (SCE) can be used to identify early occupational health status in health care workers. Our aim is to comprehensively assess the relationship between long-term exposure to antineoplastic drugs (ADs) and SCE in health care workers via meta-analysis.

Methods:
Five databases were systematically searched for relevant articles published from inception to November 30, 2022. Literature data are expressed as mean difference and 95% confidence intervals (CI) or relative risk and 95% CI. For I
2 > 50% trials, random effect model is used for statistical analysis, otherwise fixed effect model is used. This review was registered in the International Prospective Register of Systematic Reviews (identifier CRD42023399914).

Results:
Fourteen studies were included in this study. Results showed the level of SCE in healthcare workers exposed to ADs was significantly higher than in controls. The mean difference of the SCE trial was 0.53 (95% CI: 0.10–0.95, P = .01) under a random-effects model.

Conclusions:
The findings suggested a significant correlation between occupational exposure to ADs in health care workers and SCE, requiring the attention of health care workers in general.
Unintended findings: Therapeutic effects of hormones or gamma globulins on Lentiform Fork sign in 3 diabetic uremic patients: Case report/case series
Authors: Li Hui , Chen Wenbiao 
Published: August 2023

Introduction:
The lentiform fork sign (LFS) is a unique magnetic resonance imaging (MRI) finding characterized by a bright hyperintense rim delineating the lentiform nucleus as a fork associated with metabolic acidosis in end-stage renal disease.

Patient concerns:
We report 3 cases of LFS in diabetic uremic patients. In one case of uremia, intensive hemodialysis treatment was not effective. Given our poor understanding of LFS, it was regarded as bilateral basal ganglia pathology, and pulse hormone and gamma globulins therapy was initiated. The patient neurological symptoms improved, and the pathological signs on imaging subsided. Based on our experience with the first LFS case, 2 diabetic uremic cases presenting with LFS were successfully treated with hormone or gamma globulin pulse therapy in addition to intensive hemodialysis.

Diagnosis:
Based on the clinical manifestations, past medical history and MRI imaging changes of the 3 cases reported here, the diagnosis of LFS was established.

Interventions:
Our experience from these 3 cases suggests that hormone supplementation and gamma globulin therapy may be indicated for treating LFS.

Lessons:
Our findings highlight that in diabetic uremic dialysis patients with neurological symptoms, LFS should be suspected. The clinical manifestations, past medical history and MRI imaging findings are essential for diagnosing LFS. Hormone supplementation and gamma globulin therapy may be the effective treatment for LFS.
Integrated network pharmacology analysis and in vitro validation revealed the underlying mechanism of Xiyanping injection in treating coronavirus disease 2019
Authors: Li Jialin , Guo Siyu , Tan Yingying , Zhang Jingyuan , Wu Zhishan , Stalin Antony , Zhang Fanqin , Huang Zhihong , Wu Chao , Liu Xinkui , Huang Jiaqi , Wu Jiarui 
Published: August 2023

Background:Coronavirus disease 2019 (COVID-19) has spread rapidly worldwide, leading to a pandemic. In China, Xiyanping injection (XYP) has been recommended as a drug for COVID-19 treatment in the Guideline on Diagnosis and Treatment of COVID-19 by the National Health Commission of the People Republic of China and National Administration of Traditional Chinese Medicine (Trial eighth Edition). However, the relevant mechanisms at the molecular-level need to be further elucidated.Methods:In this study, XYP related active ingredients, potential targets and COVID-19 related genes were searched in public databases. Protein-protein interaction network and module analyzes were used to screen for key targets. gene ontology and Kyoto encyclopedia of genes and genomes were performed to investigate the potentially relevant signaling pathways. Molecular docking was performed using Autodock Tools and Vina. For the validation of potential mechanism, PolyI:C was used to induce human lung epithelial cells for an inflammation model. Subsequently, CCK-8 assays, enzyme-linked immunosorbent assay, reverse transcription quantitative polymerase chain reaction and western blot were employed to determine the effect of XYP on the expression of key genes.Results:Seven effective active ingredients in XYP were searched for 123 targets in the relevant databases. Furthermore, 6446 COVID-19 disease targets were identified. Sodium 9-dehydro-17-hydro-andrographolide-19-yl sulfate was identified as the vital active compounds, and IL-6, TNF, IL-1β, CXCL8, STAT3, MAPK1, MAPK14, and MAPK8 were considered as the key targets. In addition, molecular docking revealed that the active compound and the targets showed good binding affinities. The enrichment analysis predicted that the XYP could regulate the IL-17, Toll-like receptor, PI3K-Akt and JAK-STAT signaling pathways. Consistently, further in vitro experiments demonstrated that XYP could slow down the cytokine storm in the lung tissue of COVID-19 patients by down-regulating IL-6, TNF-α, IL-1β, CXCL8, and p-STAT3.Conclusion:Through effective network pharmacology analysis and molecular docking, this study suggests that XYP contains many effective compounds that may target COVID-19 related signaling pathways. Moreover, the in vitro experiment confirmed that XYP could inhibit the cytokine storm by regulating genes or proteins related to immune and inflammatory responses.
Bibliometric analysis of trends in cardiac aging research over the past 20 years
Authors: Hao Yan , Li Bohan , Huber Sally A. , Liu Wei 
Published: August 2023

Background:
In recent years, many studies have addressed cardiac aging and related diseases. This study aims to understand the research trend of cardiac aging and find new hot issues.

Methods:
We searched the web of science core collection database for articles published between 2003 and 2022 on the topic of “cardiac aging.” Complete information including keywords, publication year, journal title, country, organization, and author were extracted for analysis. The VOS viewer software was used to generate network maps of keywords, countries, institutions, and author relationships for visual network analysis.

Results:
A total of 1002 papers were analyzed in the study. Overall, the number of annual publications on cardiac aging has increased since 2009, and new hot topics are emerging. The top 3 countries with the most publications were the United States (471 articles), China (209 articles) and Italy (101 articles). The University of Washington published the most papers (35 articles). The cluster analysis with author as the keyword found that the connections among different scholars are scattered and clustered in a small range. Network analysis based on keyword co-occurrence and year of publication identified relevant features and trends in cardiac aging research. According to the results of cluster analysis, all the articles are divided into 4 topics: “mechanisms of cardiac aging”, “prevention and treatment of cardiac aging”, “characteristics of cardiac aging”, and “others.” In recent years, the mechanism and treatment of cardiac aging have attracted the most attention. In both studies, animal models are used more often than in human populations. Mitochondrial dysfunction, autophagy and mitochondrial autophagy are hotspots in current research.

Conclusion:
In this study, bibliometric analysis was used to analyze the research trend of cardiac aging in the past 20 years. The mechanism and treatment of cardiac aging are the most concerned contents. Mitochondrial dysfunction, autophagy and mitophagy are the focus of future research on cardiac aging.
The effect of Baduanjin exercise on the physical and mental health of college students: A randomized controlled trial
Authors: Zhang Yaqun , Jiang Xin 
Published: August 2023

Background and purpose:Around the world, college students physical and mental health is deteriorating. Finding practical ways to enhance college students health is crucial. One of the traditional Chinese Qigong exercises is Baduanjin, which is possibly one of the most efficient workout techniques out there. However, it is unknown how Baduanjin practice may affect college students health. The purpose of this study was to evaluate the effect of Qigong Baduanjin on the physical and mental health of female college freshmen.Materials and methods:A total of 78 female college students were recruited and randomly divided into Baduanjin group or control group. Participants in the control group were told to keep their original habits of life and exercise. The Baduanjin exercise group received 12 weeks of Baduanjin exercise, 3 days a week and 1 hour a day. After the 12 week randomized controlled trial, the physical and mental health indexes of female students in Baduanjin group and control group were evaluated, including physical shape, physical function, physical fitness and scl-90 self-assessment scale.Results:Compared with the control group, at the end of the 12 week intervention, the weight, body mass index, diastolic blood pressure, systolic blood pressure, somatization score, obsessive-compulsive disorder score, interpersonal sensitivity score, depression score, anxiety score and phobic anxiety score of Baduanjin group decreased significantly. Compared with the control group, the vital capacity, vital capacity index, Stand test, Genchi test, Stand on 1 leg with closed eyes, standing bends and squats of the Baduanjin group have been significantly improved.Conclusion:Compared with usual activities, Qigong Baduanjin exercise has advantages in improving female college students body shape (weight and body mass index), cardiovascular and respiratory lung function, flexibility, balance ability, muscle endurance and mental health.
Lymphatic Pathways on Indocyanine Green Lymphography in Patients with Labia Minora Hypertrophy
Authors: Yuan Ye , Li Fengyong , Zhou Yu , Li Senkai , Cao Yujiao , Liu Meichen , Li Yilin , Li Qiang 
Published: August 2023

Background:
Labia minora hypertrophy (LH) is a growing aesthetic concern, yet its etiology and local lymphatic anatomy remain unclear. This study aimed to use indocyanine green (ICG) lymphography to investigate evidence of lymphedema in LH and clarify the anatomy of lymph vessels from the labia minora.

Methods:
Thirty-five patients with LH underwent preoperative ICG lymphography of their bilateral labia minora. The study reviewed demographic, ICG imaging, and measurement data to identify the characteristics of the superficial lymphatic anatomy in the labia minora.

Results:
The ICG lymphography findings revealed that 97.1% of the observed patterns were linear, and 2.9% were dermal backflow patterns. Further analysis of the linear patterns revealed the presence of 3 main superficial pathways originating from the labia minora and connecting to the labia majora and clitoral hood. These pathways were identified as the superior, median, and inferior channels. Based on the observed lymphatic mapping in the labia minora, 3 types were classified: type 1 (superior and inferior channels) accounted for 75.0% (51 sides), type 2 (median and inferior channels) accounted for 8.8% (6 sides), and type 3 (superior, median, and inferior channels) accounted for 16.2% (11 sides).

Conclusions:
The study demonstrates that ICG lymphography enables clear visualization of superficial lymph flow from the labia minora. It also suggests that lymphedema is not a common pathologic feature of LH. Understanding the lymphatic anatomy of the labia minora can provide valuable guidance for surgical interventions involving the female external genitalia.
Home ventilation for patients with end-stage chronic obstructive pulmonary disease
Authors: Raveling Tim , Rantala Heidi A. , Duiverman Marieke L. 
Published: August 2023

Purpose of the review
The number of patients with end-stage chronic obstructive pulmonary disease (COPD) treated with chronic non-invasive ventilation (NIV) has greatly increased. In this review, the authors summarize the evidence for nocturnal NIV and NIV during exercise. The authors discuss the multidisciplinary and advanced care of patients with end-stage COPD treated with NIV.

Recent findings
Nocturnal NIV improves gas exchange, health-related quality of life and survival in stable hypercapnic COPD patients. Improvements in care delivery have been achieved by relocating care from the hospital to home based; home initiation of chronic NIV is feasible, non-inferior regarding efficacy and cost-effective compared to in-hospital initiation. However, the effect of NIV on symptoms is variable, and applying optimal NIV for end-stage COPD is complex. While exercise-induced dyspnoea is a prominent complaint in end-stage COPD, nocturnal NIV will not change this. However, NIV applied solely during exercise might improve exercise tolerance and dyspnoea. While chronic NIV is often a long-standing treatment, patient expectations should be discussed early and be managed continuously during the treatment. Further, integration of advance care planning requires a multidisciplinary approach.

Summary
Although chronic NIV is an effective treatment in end-stage COPD with persistent hypercapnia, there are still important questions that need to be answered to improve care of these severely ill patients.
PyHFO: Lightweight Deep Learning-powered End-to-End High-Frequency Oscillations Analysis Application
Authors: Zhang Yipeng , Liu Lawrence , Ding Yuanyi , Chen Xin , Monsoor Tonmoy , Daida Atsuro , Oana Shingo , Hussain Shaun , Sankar Raman , Aria Fallah , Engel Jerome , Staba Richard J. , Speier William , Zhang Jianguo , Nariai Hiroki , Roychowdhury Vwani 
Published: August 2023

AbstractIn the context of epilepsy studies, intracranially-recorded interictal high-frequency oscillations (HFOs) in EEG signals are emerging as promising spatial neurophysiological biomarkers for epileptogenic zones. While significant efforts have been made in identifying and understanding these biomarkers, deep learning is carving novel avenues for biomarker detection and analysis. Yet, transitioning such methodologies to clinical environments is difficult due to the rigorous computational needs of processing EEG data via deep learning. This paper presents our development of an advanced end to end software platform, PyHFO, aimed at bridging this gap. PyHFO provides an integrated and user-friendly platform that includes time-efficient HFO detection algorithms such as short-term energy (STE) and Montreal Neurological Institute and Hospital (MNI) detectors and deep learning models for artifact and HFO with spike classification. This application functions seamlessly on conventional computer hardware. Our platform has been validated to adeptly handle datasets from 10-minute EEG recordings captured via grid/strip electrodes in 19 patients. Through implementation optimization, PyHFO achieves speeds up to 50 times faster than the standard HFO detection method. Users can either employ our pre-trained deep learning model for their analyses or use their EEG data to train their model. As such, PyHFO holds great promise for facilitating the use of advanced EEG data analysis tools in clinical practice and large-scale research collaborations.
Young Maternal Age at first birth and Child Undernutrition in Bangladesh: Evidence from the Bangladesh Demographic Health Survey 2017-18
Authors: Hossain Md. Alamgir , Tariqujjaman Md. , Das Novel Chandra , Chandrima Rubaiya Matin , Islam S.M Hasibul , Rahman Ahmed Ehsanur , Mahmood Hassan Rushekh , Hossain Aniqa Tasnim 
Published: August 2023

AbstractBackgroundChildhood undernutrition is a serious public health issue that includes stunting, wasting, and underweight. In Bangladesh, many adolescent girls become mothers early. Giving birth at a young age is common, adversely affecting maternal health and child undernutrition. This study investigated the association between maternal age at first birth and undernutrition of under-five children in Bangladesh.MethodsThe study is cross-sectional and data was collected from BDHS 2017–18 survey. Mothers who were pregnant at the age of ≤ 19 years were regarded as young mothers and aged >19 years were regarded as adult mothers. Children were categorized as stunting (height for age), wasting (weight for height), and underweight (weight for age) based on the z-scores -2 as per WHO median growth guidelines. Multivariate logistic regression was employed to assess the association.ResultsThis study revealed that 71.5% of mothers had their first child before 19 years old. The undernutrition status of the children of younger mothers and the children of adult mothers differed significantly, stunted (p<0.001), wasted (p<0.001), and underweight (p<0.001)).Children of mothers aged under 19 years at their 1st childbirth were 1.4 times more likely to be stunted [Adjusted odds ratio (AOR): 1.4, 95% CI: 1.02-2.46; p=0.008], 1.6 times more likely to be wasted (AOR: 1.6; 95% CI: 1.09-1.78; p=0.039), 1.5 times more likely to be underweight (AOR: 1.5, 95% CI: 1.15-2.07; p=0.004) compared to children of mothers who are adults.ConclusionThis research will draw attention to the policymakers taking the necessary initiatives focus on the maternal age at the time of first birth, which will help reduce all forms of undernutrition in under-five children.
Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group
Authors: Otth Maria , Kasteler Rahel , Mulder Renée L. , Agrusa Jennifer , Armenian Saro H. , Barnea Dana , Bergeron Anne , Bhatt Neel S. , Bourke Stephen J. , Constine Louis S. , Goutaki Myrofora , Green Daniel M. , Hennewig Ulrike , Houdouin Veronique , Hudson Melissa M. , Kremer Leontien , Latzin Philipp , Ng Antony , Oeffinger Kevin C. , Schindera Christina , Skinner Roderick , Sommer Grit , Srinivasan Saumini , Stokes Dennis C. , Versluys Birgitta , Waespe Nicolas , Weiner Daniel J. , Dietz Andrew C. , Kuehni Claudia E. 
Published: August 2023

ABSTRACTChildhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Group established and convened a panel of 33 experts to develop evidence-based surveillance guidelines. We critically reviewed available evidence regarding risk factors for pulmonary dysfunction, types of pulmonary function testing, and timings of surveillance, then we formulated our recommendations. We recommend that CAYA cancer survivors and healthcare providers are aware of reduced pulmonary function risks and pay vigilant attention to potential symptoms of pulmonary dysfunction, especially among survivors treated with allogeneic haematopoietic stem cell transplantation, thoracic radiotherapy, and thoracic surgery. Based on existing limited evidence, our panel currently recommends pulmonary function testing only for symptomatic survivors. Since scarce existing evidence informs our recommendation, we highlight the need for prospective collaborative studies to address pulmonary function knowledge gaps among CAYA cancer survivors.
Impact of the COVID-19 Pandemic on Same-day Discharge Adoption Following Percutaneous Coronary Intervention for Stable CAD: A National Time Series Analysis
Authors: Thangam Manoj , Grzeskowiak Michael , Masoudi Frederick A , Bunte Matthew C , Fry Edward , Pirwitz Mark , Ottenbacher Allison , Perez Ana Cristina , Miller Collin , Benedict Sarah , Amin Amit , Parikh Sahil A. , Monteleone Peter 
Published: August 2023

AbstractBackgroundElective percutaneous coronary intervention (PCI) historically required hospitalization post procedure. Same day discharge (SDD) has emerged as a safe and cost efficient option, although the impact of the coronavirus disease of 2019 (COVID-19) pandemic on rates of SDD and associated care episode costs remains uncertain.MethodsA national sample of consecutive patients undergoing elective PCI at 42 hospitals (Ascension, St.Louis, MO) between May 2019 to April 2021 were identified using internal registry data and administrative claims data. Rates of SDD before and after the COVID-19 pandemic (March 2020) were compared using multivariable logistic regression adjusted for patient and procedural characteristics. Additionally, an interrupted time series model was used to determine the effect of the pandemic and policy on SDD rates before and after pandemic declaration. Lastly, we estimated total costs per PCI episode in pre and post pandemic periods.ResultsIn total, 12,740 interventions were performed within 42 Ascension facilities that met study eligibility criteria (5955 PCI prior to the pandemic and 6785 after). Demographic data were similar between both populations although higher rates of dyslipidemia, prior myocardial infarction, and heart failure history were noted in the post pandemic group. Pandemic declaration was associated with a higher likelihood of SDD (OR 2.09, CI 1.93-2.25, p < 0.001). From pre-pandemic to post-pandemic, mean SDD rose from 34% to 45% (p< 0.001) with an accelerated monthly SDD adoption rate after the pandemic (0.1% per month vs 1.0% per month, p=0.02). Total costs per episode were $679.52 (95% CI $476.12 – $882.92, p < 0.001) higher in the post-pandemic period, driven by increased material costs. SDD was associated with a $2137.05 (95% CI $1925.03 – $2349.07, p < 0.001) reduction in costs relative to non-SDD episodes throughout the study period.ConclusionAmong a large national risk-adjusted sample of consecutive patients, the COVID-19 pandemic accelerated adoption of SDD. As a care strategy, SDD was associated with reduced episode costs during elective PCI in the post-pandemic period.
Structural and biophysical analysis of aHaemophilus influenzaetripartite ATP-independent periplasmic (TRAP) transporter
Authors: Currie Michael J. , Davies James S. , Scalise Mariafrancesca , Gulati Ashutosh , Wright Joshua D. , Newton-Vesty Michael C. , Abeysekera Gayan S. , Subramanian Ramaswamy , Wahlgren Weixiao Y. , Friemann Rosmarie , Allison Jane R. , Mace Peter D. , Griffin Michael D.W. , Demeler Borries , Wakatsuki Soichi , Drew David , Indiveri Cesare , Dobson Renwick C.J. , North Rachel A. 
Published: August 2023

AbstractTripartite ATP-independent periplasmic (TRAP) transporters are secondary-active transporters that receive their substrates via a soluble binding protein to move bioorganic acids across bacterial or archaeal cell membranes. Recent cryo-EM structures of TRAP transporters provide a broad framework to understand how they work, but the mechanistic details of transport are not yet defined. Here we report the cryo-EM structure of theHaemophilus influenzae N-acetylneuraminate TRAP transporter (HiSiaQM) at 2.99 Å resolution (extending to 2.2 Å at the core), revealing new features. The improved resolution (the previousHiSiaQM structure is 4.7 Å resolution) permits accurate assignment of two Na+sites and the architecture of the substrate binding site, consistent with mutagenic and functional data. Moreover, rather than a monomer, theHiSiaQM structure is a homodimer. We observe lipids at the dimer interface, as well as a lipid trapped within the fusion that links the SiaQ and SiaM subunits. We show that the affinity (KD) for the complex between the solubleHiSiaP protein andHiSiaQM is in the micromolar range and that a related SiaP can bindHiSiaQM. This work provides key data that enhances our understanding of the ‘elevator-with-an-operator’ mechanism of TRAP transporters.