bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fullerenols Mitigate Radiation‐Induced Myocardial Injury
Authors: Zhang Tingjun , He Rendong , Ding Xuefeng , Zhao Maoru , Wang Chengyan , Zhu Shuang , Liao You , Wang Dongmei , Wang Hao , Guo Junsong , Liu Yaping , Zhou Zhonghui , Gu Zhanjun , Hu Houxiang 
Published: September 2023

AbstractRadiation‐induced heart disease is a serious side effect of radiation therapy that can lead to severe consequences. However, effective and safe methods for their prevention and treatment are presently lacking. This study reports the crucial function of fullerenols in protecting cardiomyocytes from radiation injury. First, fullerenols are synthesized using a simple base‐catalyzed method. Next, the as‐prepared fullerenols are applied as an effective free radical scavenger and broad‐spectrum antioxidant to protect against X‐ray‐induced cardiomyocyte injury. Their ability to reduce apoptosis via the mitochondrial signaling pathway at the cellular level is then verified. Finally, it is observed in animal models that fullerenols accumulate in the heart and alleviate myocardial damage induced by X‐rays. This study represents a timely and essential analysis of the prevention and treatment of radiological myocardial injury, providing new insights into the applications of fullerenols for therapeutic strategies.
Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3‐Energized and Microenvironment‐Modulated Hydrogel Microspheres to Impede Osteoarthritis
Authors: Xia Xiaowei , Liu Yang , Lu Yingjie , Liu Junlin , Deng Yaoge , Wu Yubin , Hou Mingzhuang , He Fan , Yang Huilin , Xu Yong , Zhang Yijian , Zhu Xuesong 
Published: September 2023

AbstractFull‐range therapeutic regimens for osteoarthritis (OA) should consider organs (joints)‐tissues (cartilage)‐cells (chondrocytes)‐organelles cascade, of which the subcellular mitochondria dominate eukaryotic cells' fate, and thus causally influence OA progression. However, the dynamic regulation of mitochondrial rise and demise in impaired chondrocytes and the exact role of mitochondrial metronome sirtuins 3 (SIRT3) is not clarified. Herein, chondrocytes are treated with SIRT3 natural agonist dihydromyricetin (DMY) or chemical antagonist 3‐TYP, respectively, to demonstrate the positive action of SIRT3 on preserving cartilage extracellular matrix (ECM). Molecular mechanical investigations disclose that SIRT3‐induced chondroprotection depended on the repression of mitochondrial apoptosis (mtApoptosis) and the activation of mitophagy. Inspired by the high‐level matrix proteinases and reactive oxygen species (ROS) in the OA environment, by anchoring gelatin methacrylate (GelMA) and benzenediboronic acid (PBA) to hyaluronic acid methacrylate (HAMA) with microfluidic technology, a dual‐responsive hydrogel microsphere laden with DMY is tactfully fabricated and named as DMY@HAMA‐GelMA‐PBA (DMY@HGP). In vivo injection of DMY@HGP ameliorated cartilage abrasion and subchondral bone sclerosis, as well as promoted motor function recovery in post‐traumatic OA (PTOA) model via recouping endogenous mtApoptosis and mitophagy balance. Overall, this study unveils a novel mitochondrial dynamic‐oriented strategy, holding great promise for the precision treatment of OA.
Bio‐Inspired Supramolecular Self‐Assembled Carbon Nitride Nanostructures for Photocatalytic Water Splitting
Authors: Dharmarajan Nithinraj Panangattu , Vidyasagar Devthade , Yang Jae‐Hun , Talapaneni Siddulu Naidu , Lee Jangmee , Ramadass Kavitha , Singh Gurwinder , Fawaz Mohammed , Kumar Prashant , Vinu Ajayan 
Published: September 2023

AbstractFast production of hydrogen and oxygen in large amounts at an economic rate is the need of the hour to cater to the needs of the most awaited hydrogen energy, a futuristic renewable energy solution. Production of hydrogen through simple water splitting via visible light photocatalytic approach using sunlight is considered as one of the most promising and sustainable approaches for generating clean fuels. For this purpose, a variety of catalytic techniques and novel catalysts have been investigated. Among these catalysts, carbon nitride is presently deemed as one of the best candidates for the visible light photocatalysis due to its unique molecular structure and adequate visible‐range bandgap. Its bandgap can be further engineered by structural and morphological manipulation or by doping/hybridization. Among numerous synthetic approaches for carbon nitrides, supramolecular self‐assembly is one of the recently developed elegant bottom‐up strategies as it is bio‐inspired and provides a facile and eco‐friendly route to synthesize high surface area carbon nitride with superior morphological features and other semiconducting and catalytic properties. The current review article broadly covers supramolecular self‐assembly synthesis of carbon nitride nanostructures and their photocatalytic water‐splitting applications and provides a comprehensive outlook on future directions.
Radical Substitution of Polyfluoroarenes and Heteroarenes Promoted by Photoredox Activation of Organozinc Iodides
Authors: Gladkov Anton A. , Levin Vitalij V. , Dilman Alexander D. 
Published: September 2023

AbstractAromatic compounds interact with organozinc reagents under photoredox conditions, leading to the substitution products. The reaction is performed under blue light irradiation via in situ generated organozinc reagents (Barbier conditions), which are oxidized by the photocatalyst, followed by radical attack at the aromatic substrate. The method works with polyfluorinated arenes, 2‐chlorobenzoxazoles, and 2‐sulfonyl‐substituted benzothiazole.
Recent Advances in Visible‐Light‐Driven C−S Bond Formation
Authors: Feng Jiaxu , Zhang Ying , Wang Xiangdi , Liu Jing , Benazzi Valentina , Lu Kui , Zhao Xia , Protti Stefano 
Published: September 2023

AbstractDue their multifaced applications, the access to organosulfur derivatives in an efficient and economical way is a challenge in organic synthesis. In this context photochemistry and photocatalysis play a crucial role in the development of innovative (and selective) Carbon‐Sulphur bond formation processes. The present review aims to collect the most recent strategies to achieve this target under visible light driven conditions.
Smart Lipid‐Based Nanoparticles in Lung Cancer Treatment: Current Status and Future Directions
Authors: Shahrivar Ramin Yousefpour , Fakhr Zahra Ahmadi , Abbasgholinejad Elham , Doroudian Mohammad 
Published: September 2023

AbstractLung cancer remains the leading cause of cancer‐related deaths worldwide, and conventional treatments for the disease often fall short. Smart nanoparticles (NPs) are emerging as a promising strategy for the treatment of lung cancer, owing to their ability to selectively deliver therapeutic agents to cancer cells while minimizing off‐target effects. Smart NPs can respond to specific stimuli such as changes in pH, temperature, or enzymes, allowing them to release their cargo only when triggered. Among the various types of smart NPs, lipid‐based NPs, including liposomes, solid lipid nanoparticles, cubosomes, and extracellular vesicles, have garnered the highest interest due to their biocompatibility, low toxicity, and versatility in encapsulating a wide variety of drugs and genetic material. This review discusses the current status of smart lipid‐based NPs in lung cancer treatment, including recent advances in targeting strategies, stimuli‐responsive NPs, and combination therapies. The challenges and opportunities associated with translating smart lipid‐based NPs for lung cancer treatment into clinical applications are also discussed. This review highlights the potential of smart lipid‐based NPs to revolutionize lung cancer treatment and improve patient outcomes.
Precise Correction of Lhcgr Mutation in Stem Leydig Cells by Prime Editing Rescues Hereditary Primary Hypogonadism in Mice
Authors: Xia Kai , Wang Fulin , Tan Zhipeng , Zhang Suyuan , Lai Xingqiang , Ou Wangsheng , Yang Cuifeng , Chen Hong , Peng Hao , Luo Peng , Hu Anqi , Tu Xiang'an , Wang Tao , Ke Qiong , Deng Chunhua , Xiang Andy Peng 
Published: September 2023

AbstractHereditary primary hypogonadism (HPH), caused by gene mutation related to testosterone synthesis in Leydig cells, usually impairs male sexual development and spermatogenesis. Genetically corrected stem Leydig cells (SLCs) transplantation may provide a new approach for treating HPH. Here, a novel nonsense‐point‐mutation mouse model (LhcgrW495X) is first generated based on a gene mutation relative to HPH patients. To verify the efficacy and feasibility of SLCs transplantation in treating HPH, wild‐type SLCs are transplanted into LhcgrW495X mice, in which SLCs obviously rescue HPH phenotypes. Through comparing several editing strategies, optimized PE2 protein (PEmax) system is identified as an efficient and precise approach to correct the pathogenic point mutation in Lhcgr. Furthermore, delivering intein‐split PEmax system via lentivirus successfully corrects the mutation in SLCs from LhcgrW495X mice ex vivo. Gene‐corrected SLCs from LhcgrW495X mice exert ability to differentiate into functional Leydig cells in vitro. Notably, the transplantation of gene‐corrected SLCs effectively regenerates Leydig cells, recovers testosterone production, restarts sexual development, rescues spermatogenesis, and produces fertile offspring in LhcgrW495X mice. Altogether, these results suggest that PE‐based gene editing in SLCs ex vivo is a promising strategy for HPH therapy and is potentially leveraged to address more hereditary diseases in reproductive system.
Rechargeable Multifunctional Anti‐Bacterial AEMs for Electrodialysis: Improving Anti‐Biological Performance via Synergistic Antibacterial Mechanism
Authors: Yao Yuyang , Mu Junjie , Li Yuan , Ma Yanjing , Xu Jingwen , Shi Yuna , Liao Junbin , Shen Zhenlu , Shen Jiangnan 
Published: September 2023

AbstractConstructing a functional layer on the surface of commercial membrane (as a substrate) to inhibit the formation of biofilms is an efficient strategy to prepare an antibacterial anion exchange membrane (AEM). Herein, a rechargeable multifunctional anti‐biological system is reported by utilizing the mussel‐inspired L‐dopa connection function on commercial AEMs. Cobalt nanoparticles (Co NPs) and N‐chloramine compounds are deposited on the AEM surface by a two‐step modification procedure. The anti‐biofouling abilities of the membranes are qualitatively and quantitatively analyzed by adopting common Gram‐negative (E. coli) and Gram‐positive (S. aureus & Bacillus) bacteria as model biofouling organisms. The optimized membrane exhibits a high stability concerning the NaCl solution separation performance within 240 min. Meantime, the mechanism of the anti‐adhesion is un‐veiled at an atomic level and molecular dynamics (MD) simulation are conducted to measure the interaction, adsorption energy and average loading by using lipopolysaccharide (LPS) of E. coli. In view of the superior performance of antibacterial surfaces, it is believed that this work could provide a valuable guideline for the design of membrane materials with resistance to biological contamination.
Multibridge VO2‐Based Resistive Switching Devices in a Two‐Terminal Configuration
Authors: Gao Xing , Roskamp Thijs J. , Swoboda Timm , Rosário Carlos M. M. , Smink Sander , Muñoz Rojo Miguel , Hilgenkamp Hans 
Published: September 2023

AbstractVanadium dioxide exhibits a hysteretic insulator‐to‐metal transition (IMT) near room temperature, forming the foundation for various forms of resistive switching devices. Usually, these are realized in the form of two‐terminal bridge‐like structures. The authors show here that by incorporating multiple, parallel VO2 bridges in a single two‐terminal device, a wider range of possible characteristics can be obtained, including a manifold of addressable resistance states. Different device configurations are studied, in which the number of bridges, the bridge dimensions, and the interbridge distances are varied. The switching characteristics of the multibridge devices are influenced by the thermal cross‐talk between the bridges. Scanning thermal microscopy (SThM) is used to image the current distributions at various voltage/current bias conditions. This work presents a route to realize devices exhibiting highly nonlinear, multistate current–voltage characteristics, with potential applications in, e.g., tunable electronic components and novel, neuromorphic information processing circuitry.
FeCl3 ⋅ 6H2O Mediated Sequential Oxidative Cleavage and Spiro Coupling of Peroxyoxindole with Cyclic‐1,3‐diketone/1‐Naphthol for the Synthesis of Spirooxindolo‐Xanthene Derivatives
Authors: Londhe Gokul S. , Gnanaprakasam Boopathy 
Published: September 2023

AbstractHerein, an efficient approach to synthesize various hexahydro‐1H‐xanthene‐1,8‐dione or dibenzo xanthene containing bioactive spirooxindole derivatives is reported by using FeCl3 ⋅ 6H2O mediated spiro coupling of 1,3‐diketone or naphthalene‐1‐ol with peroxyoxindole. This new approach proceeds via a sequential oxidative cleavage of the C−C bond of peroxyoxindoles to generate the isatin intermediate and further reaction with two molecules of cyclic‐1,3 diketones through a series of reactions such as Knoevenagel condensation, Michael addition, and dehydration in one‐pot conditions. Furthermore, this sequential reaction of peroxyoxindole with malononitrile afforded 2‐(2‐oxoindolin‐3‐ylidene)malononitriles in very good yields in the presence of the most abundant Fe‐catalyst. A plausible mechanistic pathway in this transformation has been supported with experimental evidence and control experiments.
The intersection of social determinants of health and family care of people living with Alzheimer's disease and related dementias: A public health opportunity
Authors: Gaugler Joseph E. , Borson Soo , Epps Fayron , Shih Regina A. , Parker Lauren J. , McGuire Lisa C. 
Published: September 2023

AbstractIn this Perspective article, we highlight current research to illustrate the intersection of social determinants of health (SDOHs) and Alzheimer's disease and related dementia (ADRD) caregiving. We then outline how public health can support ADRD family caregivers in the United States. Emerging research suggests that family care for persons with ADRD is influenced by SDOHs. Public health actions that address these intersections such as improved surveillance and identification of ADRD caregivers; building and enhancing community partnerships; advancing dementia‐capable health care and related payment incentives; and reducing the stigma of dementia and ADRD caregiving can potentially enhance the health and well‐being of dementia caregivers. By engaging in one or all of these actions, public health practitioners could more effectively address the myriad of challenges facing ADRD caregivers most at risk for emotional, social, financial, psychological, and health disruption.
The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022
Authors: Veitch Dallas P. , Weiner Michael W. , Miller Melanie , Aisen Paul S. , Ashford Miriam A. , Beckett Laurel A. , Green Robert C. , Harvey Danielle , Jack Clifford R. , Jagust William , Landau Susan M. , Morris John C. , Nho Kwangsik T. , Nosheny Rachel , Okonkwo Ozioma , Perrin Richard J. , Petersen Ronald C. , Rivera Mindt Monica , Saykin Andrew , Shaw Leslie M. , Toga Arthur W. , Tosun Duygu ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2023

AbstractThe Alzheimer's Disease Neuroimaging Initiative (ADNI) aims to improve Alzheimer's disease (AD) clinical trials. Since 2006, ADNI has shared clinical, neuroimaging, and cognitive data, and biofluid samples. We used conventional search methods to identify 1459 publications from 2021 to 2022 using ADNI data/samples and reviewed 291 impactful studies. This review details how ADNI studies improved disease progression understanding and clinical trial efficiency. Advances in subject selection, detection of treatment effects, harmonization, and modeling improved clinical trials and plasma biomarkers like phosphorylated tau showed promise for clinical use. Biomarkers of amyloid beta, tau, neurodegeneration, inflammation, and others were prognostic with individualized prediction algorithms available online. Studies supported the amyloid cascade, emphasized the importance of neuroinflammation, and detailed widespread heterogeneity in disease, linked to genetic and vascular risk, co‐pathologies, sex, and resilience. Biological subtypes were consistently observed. Generalizability of ADNI results is limited by lack of cohort diversity, an issue ADNI‐4 aims to address by enrolling a diverse cohort.
Awake rabbit model of ischemic spinal cord injury with delayed paraplegia: The role of ambient temperature
Authors: Yang Wang , Wu Qian‐qian , Yang Lu , Chen Yu‐jie , Jiang Ren‐qing , Zou Ling , Liu Qing‐shan , Shi Guang‐you , Cao Jiang , Yang Xiao‐chao , Sun Jian 
Published: September 2023

AbstractBackgroundParaplegia after spinal cord ischemia is a devastating condition in the clinic. Here, we develop an awake rabbit model of spinal cord ischemia with delayed paraplegia and explore the influence of ambient temperature on the outcomes after injury.MethodsA total of 47 male rabbits were involved in the present study. Transient spinal cord ischemia was induced by occluding the infrarenal abdominal aorta of awake rabbits at different ambient temperatures. To find the optimal conditions for developing delayed paraplegia, hindlimb motor function after ischemia was evaluated between experiments.ResultsThe onset and magnitude of ischemic injury varied with the ambient temperature maintained during the peri‐ischemia period. More serious spinal cord injury occurred when ischemia was induced at higher temperatures. At 18°C, 25‐minute ischemia resulted in 74% of rabbits developing delayed paraplegia. At a temperature of 28°C or higher, most of the animals developed acute paraplegia immediately. While at 13°C, rabbits usually regained normal motor function without paraplegia.ConclusionThis awake rabbit model is highly reproducible and will be helpful in future studies of delayed paraplegia after spinal cord ischemia. The ambient temperature must be considered while using this model during investigation of therapeutic interventions.
Merging Manganese and Iminium Catalysis: Selective Hydroalkenylation of Unsaturated Aldehydes and Ketones
Authors: Zhao Chuan‐Gang , Du Chaoyu , Guo Zhenyu , Li Weipeng , Han Jie , Xie Jin 
Published: September 2023

AbstractThe use of synergistic catalytic strategy can usually circumvent the intrinsic limitations of one catalytic system. In this communication, we disclose a cooperative catalysis strategy of manganese and iminium catalysis to realize selective hydroalkenylation of unsaturated aldehydes and ketones. Its success stems from the LUMO activation of unsaturated carbonyl compounds with secondary amines as the organocatalyst and the synergistic HOMO activation of alkenylboronic acids with Mn2(CO)8Br2. This protocol exhibits several synthetic advances, e.g., simple operation, good functional group compatibility and good regioselectivity. The theoretical calculation indicates the migratory insertion followed by demetallation‐isomerization process is kinetically more favorable than Michael‐like nucleophilic addition. The use of proline‐derived organocatalyst can deliver the desired products in moderate enantioselectivity.
Distinct Selectivity Control in Solar‐Driven Bio‐Based α‐Hydroxyl Acid Conversion: A Comparison of Pt Nanoparticles and Atomically Dispersed Pt on CdS
Authors: You Yong , Han Peijie , Song Song , Luo Wei , Zhao Shengnan , Han Kaijie , Tian Ye , Yan Ning , Li Xingang 
Published: September 2023

AbstractSolar‐driven photocatalytic lignocellulose conversion is a promising strategy for the sustainable production of high‐value chemicals, but selectivity control remains a challenging goal in this field. Here, we report efficient and selective conversion of lignocellulose‐derived α‐hydroxyl acids to tartaric acid derivatives, α‐keto acids, and H2 using Pt‐modified CdS catalysts. Pt nanoparticles on CdS selectively produce tartaric acid derivatives via C−C coupling, while atomically dispersed Pt on CdS switches product selectivity to the oxidation reaction to produce α‐keto acids. The atomically dispersed Pt species stabilized by Pt−S bonds promote the activation of the hydroxyl group and thus switch product selectivity from tartaric acid derivatives to α‐keto acids. A broad range of lignocellulose‐derived α‐hydroxyl acids was applied for preparing the corresponding tartaric acid derivatives and α‐keto acids over the two Pt‐modified CdS catalysts. This work highlights the unique performance of metal sulfides in coupling reactions and demonstrates a strategy for rationally tuning product selectivity by engineering the interaction between metal sulfide and cocatalyst.
Construction of Negative Electrostatic Pore Environments in a Scalable, Stable and Low‐Cost Metal‐organic Framework for One‐Step Ethylene Purification from Ternary Mixtures
Authors: Wen Hui‐Min , Yu Chenyi , Liu Miaoyu , Lin Chenyan , Zhao Beiyu , Wu Hui , Zhou Wei , Chen Banglin , Hu Jun 
Published: September 2023

AbstractOne‐step separation of C2H4 from ternary C2 mixtures by physisorbents remains a challenge to combine excellent separation performance with high stability, low cost, and easy scalability for industrial applications. Herein, we report a strategy of constructing negative electrostatic pore environments in a stable, low‐cost, and easily scaled‐up aluminum MOF (MOF‐303) for efficient one‐step C2H2/C2H6/C2H4 separation. This material exhibits not only record high C2H2 and C2H6 uptakes, but also top‐tier C2H2/C2H4 and C2H6/C2H4 selectivities at ambient conditions. Theoretical calculations combined with in situ infrared spectroscopy indicate that multiple N/O sites on pore channels can build a negative electro‐environment to provide stronger interactions with C2H2 and C2H6 over C2H4. Breakthrough experiments confirm its exceptional separation performance for ternary mixtures, affording one of the highest C2H4 productivity of 1.35 mmol g−1. This material is highly stable and can be easily synthesized at kilogram‐scale from cheap raw materials using a water‐based green synthesis. The benchmark combination of excellent separation properties with high stability and low cost in scalable MOF‐303 has unlocked its great potential in this challenging industrial separation.
Degradation behavior of polylactic‐co‐glycolic acid and polycaprolactone with nanosilver scaffolds
Authors: Dou Dandan , Zhang Yang , Zhou Jin , Li Linhao , Wang Lizhen 
Published: September 2023

AbstractUreteral stents are commonly used in clinical treatment of ureteral diseases. There were a series of complications, such as biofilms and crusts caused by bacteria after surgery. Therefore, biodegradable with bacteriostatic ureteral scaffolds would be the potential to solve above mentioned problems. In this study, nanosilver (AgNP) was added to the polylactic‐co‐glycolic acid (PLGA) and polycaprolactone (PCL) to prepare biodegradable antibacterial ureteral scaffold samples by 3D printing. The biocompatibility, antibacterial properties, degradability, and mechanical properties of samples were observed. The samples were under a strong inhibitory effect on both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), and the higher the concentration of AgNP, the stronger the antibacterial effect. When the concentration of AgNP was 10%, the antibacterial effect was up to 100%. AgNP was released continually with the degradation of samples, which can achieve a continuous antibacterial effect. The breaking strength of the samples without and with AgNP were 6.08 ± 1.16 MPa and 26.02 ± 2.00 MPa. The mechanical properties of samples with AgNP were higher than those without AgNP. It provides a potential way to design ureteral scaffolds based on biodegradable polymers with AgNP in the clinic.