bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ecotoxicological parameters of the application of biopesticides, development and adaptation of biological systems of apple protection against pests and diseases to the soil-climatic and phytosanitary conditions of the agrocenose
Authors: Borzykh O. , Bublyk L. , Hunchak M. , Gavrylyuk L. , Shevchuk O. , Vlasova O. 
Published: April 2023

Goal. Ecotoxicological and economic substantiation of the biological system of apple protection against pests and diseases, its optimization and adaptation to the weather and climatic conditions and the phytosanitary state of apple agrocenosis in the Precarpathian province of the Carpathian mountain zone of Ukraine in order to reduce crop losses and improving its quality.
Methods. Phytosanitary monitoring was performed visually and using pheromone traps. The degree of hazard of pesticides was assessed by an integrated 7-point scale, the risk — by agroecotoxicological index (AETI).
Results. Based on the monitoring of the phytosanitary state of the apple agrocenosis in 2015—2017, scientific and methodological parameters of ecologically safe and cost-effective protection systems for apple trees adapted to the soil and climatic conditions of the Precarpathian province of the Carpathian mountain zone of Ukraine were developed: biological and biological-chemical. They are based on 7 treatments with biological or chemical and biological preparations, carried out in the phenophases of culture critical for the development of harmful organisms. The efficiency of the biological system against harmful organisms was in the range of 65.7—72.8%, the biological-chemical system — 66.4—96.5%. It is shown that replacing a number of chemical treatments with biological ones allows to minimize the negative impact of pesticides on the apple agrocenosis.
Conclusions. A model of ecologically safe protection of an apple orchard against a complex of harmful organisms has been developed. It is shown that the modern assortment of biological protection means makes it possible to develop a system that provides effective protection of the apple orchard against a complex of diseases and pests. Calculations showed that the system of biological and chemical protection was more effective in terms of profitability during the years of research (71.4—127.23%). The profit obtained from the use of this system was from 49 898.9 to 107 586.4 UAH/ha.
The Possibility of Modeling the Very High Energy Afterglow of GRB 221009A in a Wind Environment
Authors: Ren Jia , Wang Yun , Zhang Lu-Lu , Dai Zi-Gao 
Published: April 2023

Abstract
In this paper, we model the dynamics and radiation physics of the rarity event GRB 221009A afterglow in detail. By introducing a top-hat jet that propagates in an environment dominated by stellar winds, we explain the publicly available observations of afterglow associated with GRB 221009A over the first week. It is predicted that GRB 221009A emits a luminous very high energy afterglow based on the synchrotron self-Compton (SSC) process in our model. We show the broadband spectral energy distribution (SED) analysis results of GRB 221009A and find that the SSC radiation component of GRB 221009A is very bright in the 0.1–10 TeV band. The integrated SED shows that the SSC emission in the TeV band has detection sensitivity significantly higher than that of LHASSO, MAGIC, and CTA. However, since the release of further observations, deviations from the standard wind environment model have gradually shown up in data. For example, the late-time multiband afterglow cannot be consistently explained under the standard wind environment scenario. It may be necessary to consider modeling with a structured jet with complex geometry or a partial revision of the standard model. Furthermore, we find that the inclusion of GeV observations could break the degeneracy between model parameters, highlighting the significance of high-energy observations in determining accurate parameters for GRB afterglows.
GRB 211211A: A Neutron Star–White Dwarf Merger?
Authors: Zhong Shu-Qing , Li Long , Dai Zi-Gao 
Published: April 2023

Abstract
The gamma-ray burst GRB 211211A and its associated kilonova-like emission were reported recently. A significant difference between this association event and GRB 170817A/AT 2017gfo is that GRB 211211A has a very long duration. In this Letter, we show that this association event may arise from a neutron star–white dwarf (NS–WD) merger if the central engine leaves a magnetar behind. Within the NS–WD merger, the main burst of GRB 211211A could be produced by magnetic bubble eruptions from toroidal magnetic field amplification of the premerger NS. This toroidal field amplification can be induced by the runaway accretion from the WD debris disk if the disk is in low initial entropy and efficient wind, while the extended emission of GRB 211211A is likely involved with magnetic propelling. The observed energetics and duration of the prompt emission of GRB 211211A can be fulfilled in comparison with those of accretion in a hydrodynamical thermonuclear simulation, as long as the WD has a mass ≳1M
⊙. Moreover, if the X-ray plateau in GRB afterglows is due to the magnetar spin-down radiation, GRB optical afterglows and kilonova-like emission can be jointly well modeled combining the standard forward shock with the radioactive decay power of 56Ni adding a rotational power input from the postmerger magnetar.
France services, rapprocher les services publics des usagers
Authors: Clediere Guillaume 
Published: April 2023

Annoncé par le président de la République en 2019, le déploiement du réseau France services vise à offrir un accompagnement personnalisé et de proximité aux usagers dans leurs principales démarches administratives de la vie quotidienne. Actuellement, 2 561 France services ont été déployées sur l’ensemble du territoire français, offrant ainsi à plus de 99% des Français un accès à moins de 30 minutes de leur domicile. Depuis le lancement du programme, plus de 12 millions de démarches ont été accompagnées par les conseillers France services en lien avec les neuf partenaires du dispositif. Fort des résultats acquis, il convient désormais de consolider, structurer et pérenniser le réseau France services. À cet égard, des chantiers importants ont été engagés, notamment en matière de maillage territorial, de qualité de service, d’offre de service et de ressources humaines.
L’épreuve de l’enseignement moral et civique à l’école
Authors: Fix-Lemaire Séverine 
Published: April 2023

Cet article interprétatif à visée compréhensive, concrétisé par une construction de cas, s’intéresse à l’enseignement moral et civique (EMC) dans le 1er degré en France dans une perspective clinique d’orientation psychanalytique en sciences de l’éducation et de la formation. Cet enseignement, qui vise une éducation à la citoyenneté, semble soumettre certains enseignants à une épreuve au sens de Terrisse (1994). L’enseignement moral et civique est une épreuve pour Romy, car la nature des savoirs mis en jeu dans cet enseignement, ainsi que leur mise en œuvre, provoquent chez elle une tension entre instruire et éduquer qui ravive un conflit psychique. Au regard de ce cas, les formations professorales en enseignement moral et civique gagneraient à proposer un accompagnement. Celui-ci, en prenant en charge, par la parole adressée, l’embarras que l’enseignement de l’EMC peut constituer pour certains professeurs des écoles, permettrait à ces enseignants, dans la logique exposée par Devereux (1967/2012), « de se comprendre [eux]- même[s] » pour traverser l’épreuve de l’enseignement moral et civique.
Répercussions psychiques d’une grave maladie de l’enfant
Authors: Serisé-Dupuis Anne 
Published: April 2023

Une maladie grave peut évoluer vers une situation palliative pour laquelle il n’y a pas de guérison et où le pronostic vital est en jeu. Au début du XX e siècle, les premiers psychanalystes qui ont observé et étudié les effets de la maladie sur les jeunes enfants sont René Spitz à New-York [1] , John Bowlby [2] à Londres. René Spitz a développé la notion d’hospitalisme et de dépression anaclitique. Ils ont surtout orienté leurs travaux sur les répercussions de la séparation de l’enfant d’avec sa mère. Leurs enquêtes, leurs films ont modifié le regard porté par l’adulte à ces enfants. Il se développe alors l’idée que ce n’est pas la réalité de la maladie qui compte mais comme le dit Anna Freud [3] : « l’état de maladie dans ses répercussions sur le monde intérieur de l’enfant.
L’épreuve et la crise : trois portraits pour penser l’expérience du travail contemporain
Authors: Besson Madeleine , Bia Figueiredo Marie , Moriceau Jean-Luc 
Published: April 2023

Lors d’une étude sur l’expérience du travail durant la crise sanitaire, le concept d’épreuve s’est imposé. Il permet de penser la diversité des expériences et parcours, en soulignant les aspects de défi à surmonter, de mise à l’épreuve, d’expérience éprouvante et existentielle. L’importance de l’épreuve dans l’expérience et le travail a été conceptualisée notamment par Martuccelli, Boltanski et Pezé ; plus récemment Rosanvallon a mis en valeur le rôle des émotions et des attentes que suscitent les épreuves. Les crises rendent plus visibles et plus aigües certaines épreuves, et mettent en évidence une dimension grandissante du management : celle de contribuer à faire face à des épreuves qui le mettent à l’épreuve et le contraignent à se transformer.
De la relation d’aide numérisée. Les assistants sociaux face au numérique
Authors: Barré Sophie 
Published: April 2023

En trente ans, la révolution numérique a profondément bouleversé nos sociétés. De nouvelles formes de communication (courriel, réseaux sociaux, messagerie instantanée, blogs…) créent un réseau planétaire entre les individus. « Les travailleurs sociaux ont toujours su adapter leurs pratiques aux publics, au contexte sociétal, aux politiques d’action sociale, aux législations, aux outils. » Mais le numérique confronte les travailleurs sociaux à un ensemble de technologies qui impacte à la fois les relations avec les personnes accompagnées et leurs pratiques professionnelles.
Los Carabidae (Insecta: Coleoptera) del valle de Salientes (León, norte de España): fauna, corología y notas taxonómicas
Authors: Ortuño Vicente M. , Arribas Óscar , Andrés Elena 
Published: April 2023

El valle de Salientes (norte de León, España) es un área situada inmediatamente al sur del eje principal de la Cordillera Cantábrica, de la que se halla relativamente aislada debido a los procesos erosivos producidos entre las cabeceras de los ríos Sil y Luna. Este hecho histórico/geológico convierte a este valle en un enclave muy singular y a su biota en un interesante objetivo de estudio. Este trabajo, con un enfoque faunístico, aporta información sobre Carabidae (Insecta, Coleoptera) que habitan en esta área. Se realizaron cuatro campañas entomológicas en tres años consecutivos, donde se recogieron 1255 especímenes, pertenecientes a 101 especies, en 61 puntos de muestreo, mediante captura activa e instalación de trampas pitfall. Los resultados revelan que, en términos de diversidad específica y abundancia, la mayoría de los ejemplares pertenecen a la subfamilia Harpalinae, teniendo especial relevancia Harpalini (18 spp, 167 exx), Zabrini (11 spp, 55 exx), Pterostichini (10 spp, 200 exx), Sphodrini (9 spp, 150 exx) y Platynini (6 spp, 83 exx). Además, se realizó un análisis biogeográfico que puso de manifiesto la elevada contribución que hacen los endemismos ibéricos en la composición faunística de los Carabidae de este enclave geográfico. Finalmente, se discuten aspectos taxonómicos de algunas especies colectadas: 1) el caso de Trechus (Trechus) suturalis Putzeys, 1870 y Trechus (Trechus) gallaecus Jeannel, 1921, cuya morfologíadel edeago, ilustrada en este trabajo, es clave para la distinción inequívoca de ambas especies; 2) también se pone de manifiesto la gran variabilidad observada respecto a los caracteres externos de dos especies ibéricas de Oreophilus Chaudoir, 1838, Pterostichus (O.) cantaber (Chaudoir, 1868) y Pterostichus (O.) franzi Nègre, 1955, concluyendo que no son lo suficientemente consistentes, teniendo que recurrir a la morfología del edeago como único carácter totalmente fiable para identificar ambas especies. Además, se aportan comentarios en relación con la autoecología y preferencia de hábitat (áreas forestales, riparias/palustres, ruderales y subterráneas) de las especies más representativas. Por último, se amplía el rango de distribución del microendemismo Trechus teverganus Toribio, 2015, a pesar de las aparentes barreras geográficas y geológicas que podrían existir para esta especie de vida subterránea.
Multi-omics integration and interactomics reveals molecular networks and regulators of the beneficial effect of yoga and exercise
Authors: Khokhar Manoj , Tomo Sojit , Gadwal Ashita , Purohit Purvi 
Published: April 2023

Background:
Yoga is a multifaceted spiritual tool that helps in maintaining health, peace of mind, and positive thoughts. In the context of asana, yoga is similar to physical exercise. This study aims to construct a molecular network to find hub genes that play important roles in physical exercise and yoga.

Methodology:
We combined differentially expressed genes (DEGs) in yoga and exercise using computational bioinformatics from publicly available gene expression omnibus (GEO) datasets and identified the codifferentially expressed mRNAs with GEO2R. The co-DEGs were divided into four different groups and each group was subjected to protein–protein interaction (PPI) network, pathways analysis, and gene ontology.

Results:
Our study identified immunological modulation as a dominant target of differential expression in yoga and exercise. Yoga predominantly modulated genes affecting the Th1 and NK cells, whereas Cytokines, Macrophage activation, and oxidative stress were affected by exercise. We also observed that while yoga regulated genes for two main physiological functions of the body, namely Circadian Rhythm (BHLHE40) and immunity (LBP, T-box transcription factor 21, CEACAM1), exercise-regulated genes involved in apoptosis (BAG3, protein kinase C alpha), angiogenesis, and cellular adhesion (EPH receptor A1).

Conclusion:
The dissimilarity in the genetic expression patterns in Yoga and exercise highlights the discrete effect of each in biological systems. The integration and convergences of multi-omics signals can provide deeper and comprehensive insights into the various biological mechanisms through which yoga and exercise exert their beneficial effects and opens up potential newer research areas.
Effect of Tratak (Yogic Ocular Exercises) on Intraocular Pressure in Glaucoma
Authors: Sankalp  , Dada Tanuj , Yadav Raj Kumar , Sharma Hanjabam Barun , Netam Ritesh Kumar , Kochhar Kanwal Preet 
Published: April 2023

Introduction:
In healthy subjects, the intraocular pressure (IOP) is maintained by a dynamic equilibrium between continuous production of aqueous humor by ciliary bodies and continuous outflow through the two drainage pathways: trabecular meshwork and uveoscleral outflow. Here, we hypothesized that yogic ocular exercises, including extraocular muscles exercise, and modified Tratak Kriya (mTK), might reduce the IOP as well as stress and improve quality of life (QoL) in patients with glaucoma.

Methodology:
A parallel two-arm randomized controlled trial (RCT) was conducted in glaucoma patients (Control group and Intervention group). Control group patients were on standard medical treatment and intervention group patients practiced a Yoga-based lifestyle intervention (YBLI) for 4 weeks as add-on therapy with their standard medical treatment. All Participants were assessed at baseline day 1, day 14 (D14), and day 28 (D28). A minimum of 30 patients were recruited in each group.

Results:
We did not observe any statistically significant different mean IOP of right (IOP-r) or, left eyes at any time point as well as cortisol level and QoL between the two groups. However, with in intervention group, there was a reduction in IOP-r at D14 (15.54 ± 2.81 mmHg) and D28 (15.24 ± 3.1 mmHg), P = 0.006 and 0.001, respectively, compared to their baseline IOP (16.26 ± 2.98).

Conclusion:
Based on the present RCT, yoga-based ocular exercises practiced here cannot be recommended for management of raised IOP in glaucoma patients. Further larger studies are warranted with yoga-based interventions in patients with glaucoma.

Clinical Trial Registration Number:
CTRI/2016/03/006703
Kundalini Yoga Intervention Increases Hippocampal Volume in Older Adults
Authors: Ibrahim Marim , Therriault Joseph , Nair Vasavan P. , Dikaios Elena , Rosa-Neto Pedro , Walpola Ishan C. , Rej Soham , Lifshitz Michael 
Published: April 2023

Background:
Among a rapidly aging population, there is increased need for neuroprotective interventions promoting healthy neurological aging. Mind-body interventions, such as Kundalini yoga, are actively being explored as accessible means to encourage healthy aging. However, little remains known about the neurobiological effects of Kundalini yoga.

Aims:
This pilot randomized-controlled trial (RCT) examined the potential neuroprotective effects of Kundalini yoga in older adults.

Methods:
We conducted an RCT with 11 healthy meditation-naïve older adults. Participants were randomized to a Kundalini yoga or psychoeducation intervention. Structural magnetic resonance imaging data were obtained at baseline and 12-week follow-up. The primary outcome measure was gray matter volume of the bilateral hippocampi and bilateral posterior cingulate cortex.

Results:
We found significant right hippocampal volume increases specific to the Kundalini yoga group (P = 0.034, ηp
2 = 0.408).

Conclusions:
These findings provide initial neurobiological support for the neuroprotective effects of Kundalini yoga.
Long PFNA-II versus Dynamic Hip Screw for Treatment of Unstable Intertrochanteric Femur Fracture
Authors: Kumar Sanjiv , Agarwal Punit , Kumar Deepak , Kumar Ashish , Saroj Atul Kumar , Verma Ashutosh , Agarwal Rishabh 
Published: April 2023

Background:
Intertrochanteric femur fractures are one amongst the most common hip fracture presenting to our centre. Clinical efficacy and safety of PFNA and DHS in the treatment of unstable intertrochanteric fractures in elderly patients and found that compared with the control group (DHS), the observation group (PFNA) experienced shorter operation time and fracture healing time and less intraoperative blood loss, and suffered a shorter incision. The purpose of this study was to compare the functional outcomes and related complications between DHS and PFNA in treatment of unstable intertrochanteric femur fracture.

Methodology:
Total of 60 patients having unstable intertrochanteric femur fracture were included in this study and was equally divided into two groups.

Group-P
included patients with unstable intertrochanteric femur fracture managed by PFN-A II while

Group-D
patients managed by DHS. The result was analysed using descriptive statistics and making comparisons among various groups. Categorial data were summarized as in proportions and percentage (%) while discrete as mean ± SD.

Results:
At final follow-up; it was found that 72.4% of the cases of PFNA have achieved excellent union as compared to 44.4% for DHS group, 24.1% cases of PFNA have good union as compared to 51.9% in DHS group and the difference of mean DHS was significantly higher for PFNA group (p=0.001).

Conclusion:
PFNA-II have benefits like minimally invasive procedure, less soft tissue dissection, less amount of blood loss and provides better result in terms of union. Therefore PFNA-II is recommended as a better choice as compared to DHS in management of unstable intertrochanteric fractures in terms of functional outcome.
The feasibility of PETHEMA ALL-96 regimen on treatment of patients with acute lymphoid leukemia
Authors: Ashrafi Farzaneh , Sadeghi Alireza , Derakhshandeh Ali , Oghab Padideh 
Published: April 2023

Background:
Asparaginase-based treatment regimen for acute lymphocytic leukemia (ALL) is considered as feasible, but there is still a lack of data. In this study, considering the results of other regimen that were not optimum in previous studies. Here, we aimed to investigate the feasibility of PETHEMA ALL-96 treatment regimen.

Materials and Methods:
This is a retrospective feasibility study that was performed in 2019–2021 on 13 patients diagnosed with B-cell ALL. Patients were treated by PETHEMA ALL-96 regimen during induction, consolidation, reinduction, and maintenance phases. Patients were followed for 2 years after initiation of PETHEMA ALL-96 regimen for disease-free survival (DFS) and overall survival (OS) of all patients were evaluated after 2 years.

Results:
Data of 11 patients were analyzed. Within 28 days after treatments, all patients (100%) had no blasts in the bone marrow that was considered as complete remission (CR). The CR rate was 100% within 6 months and 12 months and 81.8% within 2 years after the treatments. Evaluation of OS, CR, and DFS regarding 6, 12, and 24 months showed 100% for all items after 6 and 12 months. After 24 months, the CR was 90.9%, the OS was 81.8% and the DFS was 90.9%. None of the patients died during the induction phase and during the 12 months study. No side effects were observed.

Conclusion:
The PETHEMA ALL-96 had high feasibility and survival rates with no side effects during the study course. It is believed that PETHEMA ALL-96 regimen has beneficial outcomes in young patients with ALL.
Influence of Prior Internist Encounter on Glycaemic Control among Patients with Type 2 Diabetes Mellitus at a Family Practice Setting in Nigeria
Authors: Michael Godpower Chinedu , Grema Bukar Alhaji , Abdulkadir Zainab , Ibrahim Haliru , Haruna Abdullah Ibrahim 
Published: April 2023

Background:
The huge global diabetes burden and the paucity of diabetes specialists make primary care physicians important stakeholders in controlling diabetes. Hence, we examined the predictors of glycaemic control among primary care patients with type 2 diabetes mellitus (T2DM), highlighting the influence of prior internist encounters during the preceding year on glycaemic control.

Methods:
This questionnaire-based cross-sectional study involved 276 T2DM patients systematically recruited from attendees of a general outpatient clinic (GOPC) in Kano, Nigeria. Data regarding their sociodemographic, clinical and internist encounter and GOPC visit characteristics were collected. Data were subjected to descriptive and inferential statistical analysis.

Results:
Most participants (56.5%) were females; their mean age was 57.7 ± 9.6 years, mean glycated haemoglobin level was 7.3 ± 1.9%. Age, educational level, ethnicity, insurance status, current blood pressure (BP), treatment type, medication adherence, awareness of the importance of diet in DM control, specialist diabetic clinic visited, number of GOPC visits and prior encounter with an internist in the preceding year were associated with glycaemic control after bivariate analysis (P < 0.05). On multivariate regression, low education, retirees, being self-employed, uninsured, overweight, having optimal BP, using metformin alone, sulphonylurea-metformin and insulin-based treatments and prior encounter with the internist in the preceding year were predictors of optimal glycaemic control.

Conclusion:
There are multiple predictors of glycaemic control in this setting. These predictors should be considered in glycaemic control risk stratification towards quality individualised care, which includes establishing referral protocols to available specialists. Regular training of primary care physicians on diabetes care is also required.