bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences of sexual and reproductive health screening and counseling in the clinical setting among adolescents and young adults with rheumatic disease
Authors: Huynh Brittany , Ott Mary A. , Tarvin Stacey E. 
Published: January 2025

Abstract

Background
Our objective was to describe differences among adolescents and young adults (AYAs) with rheumatic disease using teratogens compared to non-users in receipt of sexual and reproductive health (SRH) counseling, teratogenicity knowledge, perceived importance of SRH topics, and preferences around counseling.

Methods
AYAs ages 14–23 years and assigned female at birth were recruited from pediatric rheumatology clinics at a Midwest tertiary care program. Participants completed a one-time online survey assessing SRH.

Results
One-hundred eight participants completed the survey, representing a range of rheumatic diseases. 24% reported ever having sex. 36% used a teratogen. Rates of screening and counseling regarding SRH topics were low. Notably, pregnancy prevention and emergency contraception (EC) counseling by rheumatologists were uncommon and not associated with teratogen use or sexual activity. Among AYAs on teratogens, only half reported screening for sexual activity or counseling on teratogenicity or pregnancy prevention. Gaps in pregnancy prevention and EC counseling remained even when accounting for counseling by other providers. Knowledge of medication teratogenicity was also low. AYAs reported SRH topics of high importance, and many reported recent concerns. They preferred to receive information from their rheumatologist, and most agreed it is important to talk to their rheumatologist regarding these topics.

Conclusions
AYAs with rheumatic disease report low levels of SRH screening and counseling by their rheumatologist yet report these topics are important and want to discuss them. Gaps in teratogenicity knowledge were identified. This study identifies a need for improved communication with AYAs regarding their SRH.
Preliminary study assessing the long-term surgical outcomes of TBX6-associated congenital scoliosis (TACS) patients using the propensity score matching method: exploring the clinical implications of genetic discoveries in congenital scoliosis
Authors: Lin Guanfeng , Yang Yang , Chen Zefu , Zhao Sen , Niu Yuchen , Du You , Zhao Yiwei , Wang Shengru , Wu Nan , Zhang Jianguo 
Published: January 2025

Abstract

Background
Compound inheritance of TBX6 accounts for approximately 10% of sporadic congenital scoliosis (CS) cases. Such cases are called TBX6-associated congenital scoliosis (TACS). TACS has been reported to have certain common clinical phenotypes. However, whether the surgical outcomes of TACS patients differ from those of other CS patients remains unclear.

Methods
We retrospectively searched for patients who were diagnosed with scoliosis. TACS was identified in genetic testing for CS. After propensity score matching, patients with TACS were matched with patients with NTACS according to sex, age, main curvature, classification, deformity location, surgical methods, fusion segment and number of fusions. We evaluated and compared the coronal and sagittal radiographic parameters before surgery, immediately after surgery, and at the final follow-up. Surgical information, including surgical method, fusion segment, blood loss and complications, was also compared and analyzed.

Results
Twenty-eight TACS patients were propensity score matched with 28 NTACS patients among 473 CS patients. The preoperative matching parameters mentioned in the Methods section were similar between the TACS group and the NTACS group. In the TACS group, the correction rate of the cranial compensatory curve (64.9 ± 18.6% vs. 51.2 ± 24.0%, P = 0.014) and the correction rate of the caudal compensatory curve (77.4 ± 12.5% vs. 65.4 ± 22.7%, P = 0.011) were significantly greater than those in the NTACS group, and the loss rate of correction of the cranial compensatory curve in the TACS group (0.6 ± 19.2% vs. 26.7 ± 50.8, P = 0.002) was significantly lower than that in the NTACS group. The total complication rate (7.2% vs. 14.3%) and incidence of adding-on (0 vs. 7.1%) were lower in the TACS group than in the NTACS group. There were no significant differences between the two groups in terms of blood loss, revision rate, other correction parameters, balance parameters or incidence of complications.

Conclusions
TACS patients had better surgical outcomes than NTACS patients, which means that genetic diagnosis of the TBX6 gene mutation in CS before surgery can help predict better surgical outcomes. The specific genetic mechanism is not yet clear and may be related to the relatively normal development of paravertebral tissues in TACS patients. Further research is needed.

Level of evidence
Leve: III.
The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial
Authors: Yao Yuanyuan , Zhang Xin , Ye Runyu , Jia Shanshan , Yang Xiangyu , Chen Xiaoping 
Published: January 2025

Abstract

Background
Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents. Compelling evidence has shown that such a population has a greater risk of cardiovascular events as well as mortality. Although mineralocorticoid receptor antagonists (MRAs) have been shown to be an effective fourth-line treatment for RH, a significant proportion of RH patients do not achieve their blood pressure target. Compound reserpine and triamterene tablets, a traditional Chinese quadruple single-pill combination, have been proven to have good antihypertensive effects as well as safety, and are promising effective antihypertensive drugs for treating RH.

Methods
A randomized crossover clinical trial will be conducted to compare the efficacy and safety of compound reserpine and triamterene tablets treatment regimen (two tablets of olmesartan/amlodipine (OA) + one tablet of compound reserpine and triamterene tablets) with those of a standard treatment regimen (two tablets of OA + indapamide 2.5 mg + spironolactone 20 mg) in patients with RH. Forty patients will be recruited and randomly assigned in a 1:1 ratio to 2 crossover groups. The two groups will receive different combination therapies for 6 weeks and will then switch to the other combination therapy for 6 weeks, with a 4-week wash-out. The primary outcome will be the reduction in average 24-h systolic blood pressure after 6 weeks of intervention between the two groups.

Discussion
This study aimed to evaluate whether the compound reserpine and triamterene tablets treatment regimen (A + C + 0) results in a greater reduction in blood pressure in RH patients than the standard treatment regimen (A + C + D + spironolactone).

Trial registration
Chinese Clinical Trial Registry ChiCTR2400081878. Registered on March 14, 2024 (http://www.chictr.org.cn).
Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response
Authors: Wu Jing , Lu Qi , Hou Jing , Qiu Yueqin , Tian Min , Wang Li , Gao Kaiguo , Yang Xuefen , Jiang Zongyong 
Published: January 2025

Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) presents significant economic challenges to the global pork industry due to its ability to mutate rapidly. The current commercial vaccines have limited effectiveness, and there are strict restrictions on the use of antiviral chemical drugs. Therefore, it is urgent to identify new strategies for preventing and controlling PRRSV infections. Baicalein, a flavonoid derived from Scutellaria baicalensis, has gained attention for its potential antiviral properties. However, there is little information about the effects and mechanisms of baicalein in relation to PRRSV. In this study, a network pharmacology analysis identified seven potential targets of baicalein against PRRSV, with the epidermal growth factor receptor (EGFR) emerging as the core target. The results of molecular docking and dynamics (MD) simulations confirmed that baicalein has a high binding affinity for EGFR, with a measured value of − 7.935 kcal/mol. Additionally, both in vitro (EC50 = 10.20 μg/mL) and in vivo (2.41 mg/kg) experiments were conducted to assess the effectiveness of baicalein against PRRSV. Notably, baicalein was found to inhibit various stages of the PRRSV replication cycle and could directly bind to PRRSV in vitro. Baicalein inhibited the entry of PRRSV by blocking EGFR phosphorylation and the downstream PI3K-AKT signaling pathway. This was confirmed by a decrease in the expression of p-EGFR/EGFR, p-AKT/AKT, PI3K, and SRC following treatment with baicalein. Additionally, baicalein significantly enhanced the immune response in piglets infected with PRRSV. In conclusion, this study suggests that baicalein may be a promising pharmaceutical candidate for preventing and controlling PRRS, offering new insights into the antiviral potential of Chinese herbal medicine.
On a modified Bernstein operators approximation method for computational solution of Volterra integral equation
Authors: Ansari Khursheed J. , Usta Fuat 
Published: January 2025

Abstract
The main feature of this paper is an application of the modified Bernstein operator in the approximate and numerical solution of integral equations. The stability of the algorithm is discussed in the context of errors resulting from the numerical approximation of Volterra integral equations. The mechanism of the proposed method is explained in detail, including its main features. Furthermore, a comparison with an alternative numerical technique is made, and the superiority of the proposed solution is shown. Numerical experiments are also performed to verify the validity of the proposed method and to assess its accuracy. Finally, several conclusions are drawn from the results of the numerical experiments. The proposed method provides a powerful and efficient tool for the approximate solution of Volterra integral equations, and its results are promising. The results obtained from this algorithm are useful in the numerical analysis of integral equations.
Providing appropriate health and social care for people with dementia or mild cognitive impairment in the criminal justice system of England and Wales: a thematic analysis of prisoner and staff interview data
Authors: O’Neill Adam , Heathcote Leanne , Archer-Power Laura , Ware Stuart , Shaw Jenny , Senior Jane , Forsyth Katrina 
Published: January 2025

Abstract

Background
The number of older adults entering the criminal justice system is growing. Approximately 8% of older prisoners in England and Wales have suspected dementia or mild cognitive impairment (MCI) and experience difficulties in everyday functioning, and disruption to their daily life. At present, no specific dementia/MCI care pathway has been implemented that is applicable and appropriate for use across different prisons in England and Wales. The aim of this paper is to explore the experiences of older adults with dementia/MCI in prison, and a range of key stakeholders, around the day-to-day issues faced by people with dementia/MCI and prison, healthcare, and third sector staff regarding the delivery of support for individuals with dementia/MCI.

Methods
Thirty-two semi structured interviews were conducted with prison, local authority, and healthcare staff; peer supporters; third sector care providers; and individuals with dementia/MCI themselves, across five establishments, to provide multidimensional perspectives of dementia/MCI in criminal justice settings. The data obtained during interviews were thematically analysed.

Results
From the data, six key themes emerged: (I) ethical concerns around trial, sentencing and detainment for people with dementia/MCI; (II) An unforgiving prison system, providing physical and social environments incompatible with supporting individuals with dementia/MCI; (III) An unprepared workforce requiring training in dementia/MCI. (IV) A lack of collaboration leading to sub-optimum management of the support needs of people with dementia/MCI in prison; (V) Peer support ‘plugging the gap’; and (VI) staff ‘hands tied behind back’.

Conclusions
Results point towards a pressing need to develop more appropriate support systems for individuals with dementia/MCI throughout the criminal justice system. Ethical concerns around the judicial process for individuals with diminished cognitive capacity must be considered. Prison governors should examine ways to make the living environment more appropriate for these individuals, and a joined-up collaborative approach to health and social care should be adopted. Staff must be appropriately trained to support and identify individuals with dementia/MCI. Peer support schemes require formal evaluation, and training/oversight of these schemes should be comprehensive.
The clinical observation of none-promyelocytic AML patients inducted with idarubicin or daunorubicin included standard regimens: a tertiary care center experience
Authors: Xu Jianhui , Song Chaoyang , He Yanjie , Huang Rui , Tu Sanfang 
Published: January 2025

Abstract

Background
Few Chinese study compared the impacts of idarubicin and daunorubicin based “3+7” intensive chemotherapies on early and long-term outcomes of AML patients through exploring their real-world data.

Patients and methods
Our none promyelocytic AML patients inducted with “3+7” regimens were studied to find out the factors relating with induction response and long term survival.

Results
Idarubicin induction was related with less chemotherapy refractory rate comparing with daunorubicin induction (10% vs 25%, P = 0.02). But cytogenetic molecular risk classification was the only independent factor relating with achieving CR after initial induction or chemotherapy refractory (P = 0.000 and 0.036). Both to overall survival (OS) and progress free survival (PFS), having transplantation and chemotherapy refractory were independent factors related, MLL rearrangement and DNA methylating related genes’ mutations as well. CR at time of transplantation and MLL rearrangement were independent factors relating both with OS after transplantation and relapse free survival after transplantation.

Conclusion
Traditional “3+7” chemotherapy regimen with idarubicin plays better in CR induction than that with daunorubicin. But the patient’s long-term survival related with clinical practice aspects, like having stem cell transplantation, as well as genetic alterations equally, like MLL rearrangement and DNA methylating related genes’ mutations.
A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis
Authors: Gubbiotti Maria A. , McCutcheon Ian E. , Rao Priya , Genovese Giannicola , Wang Linghua , Tarasov Artem , Putintsev Vladislav , Berlinski Amber , Stupichev Danil , Kriukov Kirill , Davitavyan Suren , Salem Basim , Sarachakov Alexander , Lebedev Dmitry , Hensley Michael , Bagaev Alexander , Paradiso Francesca , Kushnarev Vladimir , Khegai Gleb , Tannir Nizar M. , Msaouel Pavlos 
Published: January 2025

Abstract
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. Here we present an unusual case of a patient with renal medullary carcinoma with metastasis to the brain following treatment which included tazemetostat, an EZH2 inhibitor. The metastatic brain lesion harbored morphologic, immunohistochemical, and methylation profile supportive of a primary CNS phenotype with loss of the trimethylated lysine 27 residue of histone 3 while maintaining INI1 loss and a specific gene fusion shared with the patient’s tumor prior to initiation of tazemetostat therapy. Therefore, given the common genetic signatures in the brain metastasis and the patient’s prior tumor, this case represents a rare event of glial transdifferentiation in a brain metastasis of renal medullary carcinoma following the use of an epigenetic modulator. As renal medullary carcinoma has been known to cleverly utilize adaptive mechanisms for survival, we propose that such cell plasticity seen in this case may have been provoked by the use of a drug that alters the epigenetic signature of the tumor cells. Thus, careful assessment of tumor biology following novel therapeutic treatment options must be performed in order to note such unexpected consequences of treatment.
Comparison of the effect of quick response code-based training and traditional methods on the knowledge, skill, and satisfaction of the nursing students in using medical device
Authors: Bagheri-Nesami Masoumeh , Kamali Mahsa , Mollaei Amirabbas 
Published: January 2025

Abstract
Nurses acknowledge that their understanding of the shortcomings in the utilization of medical devices stems from insufficient knowledge about their correct usage. The use of Quick Response (QR) technology has paved a new gateway for accessing information and resources. The available evidence confirmed the usefulness of QR codes for use in clinical settings as a tool for training. The present research performed a quasi-experimental research design to compare the effect of QR code-based training and traditional methods on the knowledge, skill, and satisfaction of the nursing students in using medical device. For the control group, textual Persian manuals, visual aids in the form of pictures, and URLs were available to the students. For the intervention group, the training approach based on QR codes was explained on the first day of their presence at the heart center. The knowledge, skill and satisfaction evaluations were conducted at the end of the clinical course on day 10. The group of nursing students who used the QR code-based training method had a statistically significant higher mean knowledge and skill score compared to the traditional training method group. The level of satisfaction among students who received training using QR codes was non-significantly higher than traditional method group. Nursing managers and educators can enhance the delivery of high-quality nursing care by using QR code.
A regional site response analysis of the Petobo area after the 2018.09.28 Palu–Donggala Indonesia earthquake using an equivalent-linear model
Authors: Kusumawardani Rini , Chang Muhsiung , Upomo Togani Cahyadi , Lopez-Caballero Fernando , Permana Dadang 
Published: January 2025

Abstract
This paper presents a site-specific seismic ground response evaluation through convolution–deconvolution analysis in the Balaroa–Petobo area during the 2018 Palu–Donggala Indonesia earthquake. The equivalent-linear ground response analysis for the earthquake time history recorded at Balaroa was carried out using DEEPSOIL software. The results of the analysis indicate that the EW component of the earthquake motion was amplified more severely (amax) than was the NS component, as it propagated to the Petobo surface. The amplification of the bedrock motion on the Petobo surface was more serious than that on the Balaroa surface, which appears to be due to the differences in the subsurface stratification and material properties of the two sites. The Fourier spectrum and response spectra also showed greater maximum spectral accelerations (Sa,max) and maximum Fourier amplitudes (Af) at the Petobo site than at the Balaroa site. The frequency of surface soil both the Petobo and Balaroa sites computed by using comparison between response spectra analysis and the local modes analysis VS/4*H was indicated the potential decline of surface soil stiffness at Petobo area appear to account for the structural damage and liquefaction flow slides during the 2018 incident.
Clinical and radiographic outcomes of extra-short implants (≤ 6 mm) in the posterior atrophic jaws: a retrospective cohort study
Authors: Sivolella Stefano , Giovannini Stefano , Berberi Joana , Stocchero Michele , Brunello Giulia 
Published: January 2025

Abstract

Objective
This study aimed at investigating implant survival rate and marginal bone loss (MBL) around extra-short implants. The impact of the loading protocol and of the use of an intermediate abutment was also evaluated, to explore possible differences in terms of the outcome measures.

Materials and methods
Patients with single or multiple mandibular or maxillary posterior edentulism rehabilitated using extra-short 5–6 mm long implants were included. Different prosthetic protocols were used. Clinical and radiological follow-up was 5 years. The outcomes measures were implant survival and MBL.

Results
The analysis included 56 implants placed in 34 adults (12 males and 22 females; mean age 60 years, SD 11). Six implants failed during a median follow-up of 5 years and 4 of them were recorded in one patient at 2-year follow-up. The 5-year implant survival was 89% overall (87% in conventional and 94% in immediate loading). At univariate analysis, during follow-up immediate loading was associated with higher MBL (mean variation 0.21 mm, 95%CI 0.01 to 0.40; p = 0.02), while intermediate abutment was associated with lower MBL (mean variation -0.23 mm, 95%CI -0.39 to -0.09; p = 0.003). Multivariable analysis confirmed that immediate loading was associated with higher MBL.

Conclusion
Within its limitations, this study showed that extra-short implants under immediate loading conditions can be a reliable solution. The application of horizontal and vertical platform switching with the use of intermediate abutments seems to be able to contribute to the reduction of MBL.

Graphical Abstract
In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders
Authors: Akanbi Stephen Tunmise , Yusuf Joshua Ayodele , Ayandele Thompson Oluwaferanmi , Oladipupo Dayo Samson , Olorunlowu Darasimi Racheal , Olawuyi Blessing Dorcas , Adepoju Joshua Oluwafisayo , Opasina Dolapo Emmanuel , Opoola Elizabeth Kehinde , Ugwuanyi Uchenna Victor , Adeleye Olufunto Omodele 
Published: January 2025

Abstract

Background
Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to depletion of the dopaminergic neurons in the substantia nigra as well as degeneration as and decreased activity in the putamen. This study aims to identify the role of putamen in non-motor PD symptoms as well as potential therapeutic target in the putamen of PD.

Methods
Transcriptome profiles of PD (dataset number: GSE205450, obtained from postmortem putamen and caudate samples from forty controls and thirty-five PD patients) were retrieved from the Gene Expression Omnibus (GEO) database. Specifically, we focused on putamen data for controls and PD patients. Differential gene expression analysis was carried out using with Limma, filtering for genes with |logFC|> 1 (fold change) and p < 0.05 (p-value). Protein–Protein Interaction networks were constructed using stringDB (combined score > 0.7) and analyzed in Cytoscape to identify hub genes based on various topological measures (EPC, MCC, MNC, Degree, and EcCentricity). Enrichment analysis of target genes was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Also, we constructed transcription factor (TF)-hub gene expression networks, miRNA-hub gene expression networks, and disease hub gene association networks using the JASPAR database, Tarbase database, and DisGeNET via NetworkAnalyst platform, respectively.

Results
Seven genes, namely SST, NPY, IL6, PVALB, ALB, NTS, and TH were identified as hub genes in PD putamen. Notable miRNAs included hsa-mir-34a-5p, hsa-mir-15a-5p, hsa-mir-424-5p, and hsa-mir-19b-3p, while key transcription factors include GATA2, CREB1, FOXC1, FOXL1, TID1, NFKB1, YY1, SPIB, GATA3, and STAT3.

Conclusions
Our findings revealed close associations between the hub genes of PD putamen and non-motor symptoms of PD such as major depressive disorder, mood disorders and schizophrenia. These findings may provide a new direction for developing therapy for non-motor symptoms of PD and wet lab research is encouraged.