bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double‐sided entire papilla preservation technique in the combination periodontal regenerative therapy: A case report
Authors: Ogawa Yudai , Yoshikawa Kouki , Ishikawa Tomohiro , Saito Atsushi , Imamura Kentaro 
Published: July 2023

AbstractBackgroundWith the entire papilla preservation (EPP) technique, it is possible to perform regenerative therapy without incisions in the interdental papilla and to reduce the risk of papillary rupture. However, one limitation of the EPP is the sole access from the buccal side. Here, we present a case of periodontitis treated by the combination regenerative therapy employing the Double‐sided (buccal‐palatal) EPP (DEPP) technique, which adds a palatal vertical incision to the EPP.MethodsA patient with 1–2 wall intrabony defects received the regenerative therapy using recombinant human fibroblast growth factor (rhFGF)‐2 and carbonate apatite (CO3Ap). Using the DEPP technique, vertical incisions at buccal and palatal aspects were placed to gain adequate access to the 1–2 wall intrabony defects between #11 and #12 without incision in the interdental papilla. After debridement, rhFGF‐2 and CO3Ap were applied to the defect. Periodontal clinical parameters and radiographic images were evaluated at the first visit, following initial periodontal therapy (baseline), 6, 9, and 12 months postoperatively.ResultsWound healing was uneventful. Scarring of the incision lines was minimal. At 12 months postoperatively, probing depth reduction was 4 mm, clinical attachment gain was 4 mm, and gingival recession was not observed. An improvement in radiopacity in the previous bone defect was observed.ConclusionThe DEPP is an innovative technique that allows approaching from both the buccal and palatal sides while ensuring flap extensibility without compromising the interdental papilla. This report suggests that the combination of regenerative therapy with the DEPP may be promising in the treatment of intrabony defects.Key pointsWhy is this case new information?

The DEPP allows a direct visual approach to a 1–2 wall intrabony defect extending from the buccal to palatal sides, and increases flap extensibility, without compromising the papilla.
What are the keys to the successful management of this case?

Assessment of three‐dimensional bone defect morphology is required. Computed tomography images are very useful. The flap elevation just under the interdental papilla should be carefully performed with a small excavator to avoid damage to the interdental papilla.
What are the primary limitations to success in this case?

Despite the addition of a palatal incision, it was not possible to obtain complete flexibility of the palatal gingiva. Caution must be taken in a case in which the distance between the interdental papilla is narrow. Even if the interdental papilla is ruptured during the operation, recovery is possible by continuing the operation and suturing the rupture at the end.
I am a burden! The self‐stigmatising role of burden beliefs in the relation between negative experiences related to health problems and mental well‐being outcomes
Authors: Lampropoulos Dimitrios , Klaas Hannah S. , Spini Dario 
Published: July 2023

AbstractIt has been suggested that liberal values such as lack of autonomy and burden discourses shape the public's relation and stigma towards people with health problems. However, previous research on the role of such values for one's well‐being is scarce. We investigated whether the perception of being a burden mediates the impact of stigma and negative life experiences on life satisfaction and health satisfaction. Our sample, drawn from a subsample of the Swiss Household Panel survey, consisted of 156 individuals reporting a mental health problem (67.9% women, Mage = 49.9) and 283 individuals reporting a physical health problem (61.5% women, Mage = 53.6). We tested a model where perceived burden, measured with three items drawn from the Acceptance of Illness Scale, mediates the impact of perceived stigma and negative social experiences on life satisfaction and health satisfaction. Analysis of direct and indirect paths provide partial evidence for our hypothesis and the model showed a good fit to the data both for persons with a mental health problem and for persons with a physical health problem. However, given the correlational nature of our data and the acceptable fit of alternative mediational models, we propose that these rather inconclusive results invite for the development of further research regarding the role of burden beliefs on stigma and well‐being. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
3‐Alkyl‐2‐Methoxypyrazines: Overview of Their Occurrence, Biosynthesis and Distribution in Edible Plants
Authors: Zamolo Francesca , Wüst Matthias 
Published: July 2023

AbstractPyrazines are ubiquitous in nature – biosynthesized by microorganisms, insects, and plants. Due to their great structural diversity, they own manifold biological functions. Alkyl‐ and alkoxypyrazines for instance play a key role as semiochemicals, but also as important aroma compounds in foods. Especially 3‐alkyl‐2‐methoxypyrazines (MPs) have been of great research interest. MPs are associated with green and earthy attributes. They are responsible for the distinctive aroma properties of numerous vegetables. Moreover, they have a strong influence on the aroma of wines, in which they are primarily grape‐derived. Over the years various methods have been developed and implemented to analyse the distribution of MPs in plants. In addition, the biosynthetic pathway of MPs has always been of particular interest. Different pathways and precursors have been proposed and controversially discussed in the literature. While the identification of genes encoding O‐methyltransferases gave important insights into the last step of MP‐biosynthesis, earlier biosynthetic steps and precursors remained unknown. It was not until 2022 that in vivo feeding experiments with stable isotope labeled compounds revealed l‐leucine and l‐serine as important precursors for IBMP. This discovery gave evidence for a metabolic interface between the MP‐biosynthesis and photorespiration.
Recent Status in Catalyst Modification Strategies for Hydrogen Production from Ethanol Steam Reforming
Authors: Meng Hao , Zhang Jian , Yang Yusen 
Published: July 2023

AbstractHydrogen as the most promising alternative energy vector to fossil stands out due to its highly energy density and zero pollution. Extending the hydrogen feedstock from hydrocarbons (e. g., methane) to biomass derived oxygen‐containing compounds (CH3OH, C2H5OH etc.) provides the opportunity for low environmental pollution as well as a promising sustainable energy economy. Recently, ethanol with less toxic and high calorific value than traditional fossil energy (coal, oil and natural gas) has garnered significant attention for ethanol steam reforming (ESR) to produce hydrogen, a key component in fuel cell cogeneration system. This paper reviews recent advances on the catalyst developing strategies including structural constitution control, oxide supports modification, surface topography control and bimetallic interactions, and further discusses the catalytic mechanisms, anti‐carbon deposition and sintering resistance strategies on the ethanol steam reforming (ESR) processes. Finally, the challenges and possible strategies for the development of high‐performance catalysts in terms of fundamental research have been discussed.
Influence of preparation parameters on the properties of SiC abrasive stones and their applications
Authors: Hanna S. B. , Ajiba N. A. , Mansour T. S. 
Published: July 2023

AbstractThe preparation of highly efficient and low cost abrasive stones has gained considerable interest in the last few years from the industrial and academic research societies. Meanwhile, composition of such abrasive stones material has played a significant role on its physicochemical, mechanical properties and cost. In this work, series of magnesium oxychloride cement samples were prepared by adding MgCl2 solutions to magnesia, where H2O/MgCl2 was 13:1, 15:1, and 17:1, while MgO/ MgCl2 molar ratio was fixed at 7:1 for all samples. During mixing, two grades of SiC were added separately in proportions of 20, 25, and 30 mass percentage. A comprehensive characterization including bulk density, compressive strength, abrasion resistance, and polishing performance were carried out to the prepared composites samples. This was followed by studying their mineral composition and the possible use in grinding and polishing processes of marble slabs. Interestingly, the obtained characterization results demonstrated that among the different prepared composite materials, 25 mass percent SiC‐containing samples showed the best physicochemical and mechanical properties. Notably, the degree of fineness of SiC has affected the overall properties of SiC composite. When very fine SiC type was used and the water content was reduced, consequently, the samples bulk density and abrasion resistance increased. Phase 5 (5Mg(OH)2.MgCl2.8H2O) and silicon carbide, as the main phases with a minor amount of magnesia, were detected in the samples. From the economic point of view, the obtained result in our study is promising for its high performance‐low cost for grinding and polishing of marble slabs in the industrial fabrication.
Versatile Synthesis of Symmetric and Unsymmetric Imines via Photoelectrochemical Catalysis: Application to N‐Terminal Modification of Phenylalanine
Authors: Chiang Chien‐Wei , Li Hung‐Li , Lin Ting‐Jun , Chen Hung‐Chi , Chou Yi‐Hsien , Chou Chih‐Ju 
Published: July 2023

AbstractA strategy that combines electrochemical synthesis and photoredox catalysis was reported for the efficient synthesis of imines. This approach was demonstrated to be highly versatile in producing various types of imines, including symmetric and unsymmetric imines, by exploring the impact of different substituents on the benzene ring of the arylamine. Additionally, the method was specifically applied to modify N‐terminal phenylalanine residues and was found to be successful in the photoelectrochemical cross‐coupling reaction between NH2‐Phe‐OMe and aryl methylamines, leading to the synthesis of phenylalanine‐containing imines. Therefore, this technique would present a convenient and efficient platform for synthesizing imines, with promising applications in chemical biology, drug development, and organic synthesis.
Electrochemical Synthesis and Reactivity of Three‐Membered Strained Carbo‐ and Heterocycles
Authors: Kumar Rakesh , Banerjee Nakshatra , Kumar Pankaj , Banerjee Prabal 
Published: July 2023

AbstractThree‐membered carbocyclic and heterocyclic ring structures are versatile synthetic building blocks in organic synthesis with biological importance. Moreover, the inherent strain of these three‐membered rings leads to their ring‐opening functionalization through C‐>C, C‐>N, and C−O bond cleavage. Traditional synthesis and ring‐opening methods for these molecules require the use of acid catalysts or transition metals. Recently, electro‐organic synthesis has emerged as a powerful tool for initiating new chemical transformations. In this review, the synthetic and mechanistic aspects of electro‐mediated synthesis and ring‐opening functionalization of three‐membered carbo‐ and heterocycles are highlighted.
Facet‐Dependent Formation and Adhesion of Au Oxide and Nanoporous Au on Poly‐Oriented Au Single Crystals**
Authors: Artmann Evelyn , Schmider Tobias , Jacob Timo , Engstfeld Albert K. 
Published: July 2023

AbstractNanoporous Au (NPG) has different properties compared to bulk Au, making it an interesting material for numerous applications. To modify the structure of NPG films for specific applications, e. g., the porosity, thickness, and homogeneity of the films, a fundamental understanding of the structure formation is essential. Here, we focus on NPG prepared via electrochemical reduction from Au oxide formed during high voltage (HV) electrolysis on poly‐oriented Au single crystal (Au POSC) electrodes. These POSCs consist of a metal bead, with faces with different crystallographic orientations and allow screening of the influence of crystallographic orientation on the structure formation for different facets in one experiment. The HV electrolysis is performed between 100 ms and 30 s at 300 V and 540 V. The amount of Au oxide formed is determined by electrochemical measurements and the structural properties are investigated by scanning electron and optical microscopy. We show that the formation of Au oxide is mostly independent of the crystallographic orientation, except for thick layers, while the macroscopic structure of the NPG films depends on experimental parameters such as the Au oxide precursor thickness and the crystallographic orientation of the substrate. Possible reasons for the frequently observed exfoliation of the NPG films are discussed.
Infigratinib, a selective FGFR1‐3 tyrosine kinase inhibitor, alters dentoalveolar development at high doses
Authors: Michel Zachary D. , Aitken Sarah F. , Glover Omar D. , Alejandro Lucy O. , Randazzo Davide , Dambkowski Carl , Martin David , Collins Michael T. , Somerman Martha J. , Chu Emily Y. 
Published: July 2023

AbstractBackgroundFibroblast growth factor receptor‐3 (FGFR3) gain‐of‐function mutations are linked to achondroplasia. Infigratinib, a FGFR1‐3 tyrosine kinase inhibitor, improves skeletal growth in an achondroplasia mouse model. FGFs and their receptors have critical roles in developing teeth, yet effects of infigratinib on tooth development have not been assessed. Dentoalveolar and craniofacial phenotype of Wistar rats dosed with low (0.1 mg/kg) and high (1.0 mg/kg) dose infigratinib were evaluated using micro‐computed tomography, histology, and immunohistochemistry.ResultsMandibular third molars were reduced in size and exhibited aberrant crown and root morphology in 100% of female rats and 80% of male rats at high doses. FGFR3 and FGF18 immunolocalization and extracellular matrix protein expression were unaffected, but cathepsin K (CTSK) was altered by infigratinib. Cranial vault bones exhibited alterations in dimension, volume, and density that were more pronounced in females. In both sexes, interfrontal sutures were significantly more patent with high dose vs vehicle.ConclusionsHigh dose infigratinib administered to rats during early stages affects dental and craniofacial development. Changes in CTSK from infigratinib in female rats suggest FGFR roles in bone homeostasis. While dental and craniofacial disruptions are not expected at therapeutic doses, our findings confirm the importance of dental monitoring in clinical studies.
Pain, mental health and healthcare utilization: Impact of the COVID‐19 pandemic on youth with chronic pain, parents and siblings
Authors: Soltani Sabine , Killackey Tieghan , Birnie Kathryn A. , Brennenstuhl Sarah , Kopala‐Sibley Daniel C. , Choiniere Manon , Pagé M. Gabrielle , Dassieu Lise , Lacasse Anaïs , Lalloo Chitra , Poulin Patricia , Ingelmo Pablo , Ali Samina , Battaglia Marco , Campbell Fiona , Smith Andrew , Benayon Myles , Jordan Isabel , Marianayagam Justina , Harris Lauren , Mohabir Vina , Stinson Jennifer , Noel Melanie ,   the COVIDChildPain Team
Published: July 2023

AbstractBackgroundPaediatric chronic pain was a public health emergency before the novel coronavirus (COVID‐19) pandemic, and this problem is predicted to escalate. Pain tends to occur intergenerationally in families, and youth with chronic pain and their parents have high rates of mental health issues, which can further exacerbate pain. Siblings of youth with chronic pain have been largely overlooked in research, as well as the impact of the pandemic on posttraumatic stress disorder (PTSD) symptoms and healthcare utilization.MethodsThis cross‐sectional study examined pain, mental health and healthcare utilization in three groups: youth with chronic pain (n = 357), parents of youth with chronic pain (n = 233) and siblings of youth with chronic pain (n = 156) during the COVID‐19 pandemic in Canada.ResultsMore so than with pain symptoms, the results revealed high levels of mental health symptoms (i.e. anxiety, depressive, and PTSD), particularly in individuals more personally impacted by the pandemic. The largest effect was seen on PTSD symptoms for all groups. For parents with chronic pain, greater personal COVID‐19 impact was related to worse pain interference. Reported rates of healthcare utilization were strikingly high, with youth with chronic pain, parents (reporting on behalf of their children with chronic pain), and siblings of youth with chronic pain reporting that most consultations were due to pain.ConclusionsLongitudinal research assessing these outcomes across continued waves of the pandemic is needed to ensure timely, tailored and equitable access to pain and mental health assessment and treatment.SignificanceThis study examined pain, mental health, substance use and healthcare utilization in youth with chronic pain, siblings and parents during the COVID‐19 pandemic. Greater personal impact of the pandemic was not largely associated with poorer pain outcomes; however, it was associated with mental health, with the largest effect on PTSD symptoms. The high rates and significant association of COVID‐19 impact with PTSD symptoms underscore the importance of including PTSD assessment as part of routine screening practices in pain clinics.
Agro‐morphological and nutritional assessment of chenopod and quinoa germplasm—Highly adaptable potential crops
Authors: Bhardwaj Rakesh , Yadav Rashmi , Vishwakarma Harinder , Sharma Kriti , Chandora Rahul , Rana Jai Chand , Riar Amritbir 
Published: July 2023

AbstractQuinoa belongs to the family Chenopodiaceae, a pseudo‐grain having high nutritional value and is considered an underexploited vegetable crop with the potential to improve the nutritional security of millions. Therefore, assessing genetic diversity in Chenopodium germplasm to untap nutritional and site‐specific adaptation potential would be of prime importance for breeders/researchers. The present study used 10 accessions of two Chenopodium species, that is, C. quinoa and C. album. Quantitative and qualitative phenotypic traits, proximate composition, minerals, and amino acids profiles were studied to compare the differences in nutritional value and extent of genetic diversity between these two species. Our results showed significant variation existed in yield attributing agro‐morphological traits. All the traits were considered for hierarchical clustering and principal components analysis. Large genetic variability was observed in traits of Chenopodium accessions. The protein, dietary fiber, oil, and sugar content ranged from 16.6% to 19.7%, 16.8% to 26%, 3.54% to 8.46%, and 3.74% to 5.64%, respectively. The results showed that C. album and C. quinoa seeds had good nutritional value and health‐promoting benefits. The C. quinoa was slightly ahead of than C. album in terms of nutritional value, but C. album accession IC415477 was at par for higher test weight, seed yield (117.02 g/plant), and other nutritional parameters with C. quinoa accessions. IC415477 and other potential accessions observed in this study may be taken up by breeders/researchers in the near future to dissect nutritional value of Chenopodium and related species for dietary diversity, which is imperative for the nutritional security of the ever‐growing world's population.
Genetic landscape of homologous recombination repair genes in early‐onset/familial prostate cancer patients
Authors: Paulo Paula , Cardoso Marta , Brandão Andreia , Pinto Pedro , Falconi Ariane , Pinheiro Manuela , Cerveira Nuno , Silva Rui , Santos Catarina , Pinto Carla , Peixoto Ana , Maia Sofia , Teixeira Manuel R. 
Published: July 2023

AbstractProstate cancer (PrCa) is one of the three most frequent and deadliest cancers worldwide. The discovery of PARP inhibitors for the treatment of tumors with deleterious variants in homologous recombination repair (HRR) genes has placed PrCa on the roadmap of precision medicine. However, the overall contribution of HRR genes to the 10%–20% of carcinomas arising in men with early‐onset/familial PrCa has not been fully clarified. We used targeted next‐generation sequencing (T‐NGS) covering eight HRR genes (ATM, BRCA1, BRCA2, BRIP1, CHEK2, NBN, PALB2, and RAD51C) and an analysis pipeline querying both small and large genomic variations to clarify their global and relative contribution to hereditary PrCa predisposition in a series of 462 early‐onset/familial PrCa cases. Deleterious variants were found in 3.9% of the patients, with CHEK2 and ATM being the most frequently mutated genes (38.9% and 22.2% of the carriers, respectively), followed by PALB2 and NBN (11.1% of the carriers, each), and finally by BRCA2, RAD51C, and BRIP1 (5.6% of the carriers, each). Using the same NGS data, exonic rearrangements were found in two patients, one pathogenic in BRCA2 and one of unknown significance in BRCA1. These results contribute to clarify the genetic heterogeneity that underlies PrCa predisposition in the early‐onset and familial disease, respectively.
Multi‐scale structural alterations of the thalamus and basal ganglia in focal epilepsy using 7T MRI
Authors: Haast Roy A. M. , Testud Benoit , Makhalova Julia , Dary Hugo , Cabane Alexandre , Le Troter Arnaud , Ranjeva Jean‐Philippe , Bartolomei Fabrice , Guye Maxime 
Published: July 2023

AbstractFocal epilepsy is characterized by repeated spontaneous seizures that originate from cortical epileptogenic zone networks (EZN). Analysis of intracerebral recordings showed that subcortical structures, and in particular the thalamus, play an important role in seizure dynamics as well, supporting their structural alterations reported in the neuroimaging literature. Nonetheless, between‐patient differences in EZN localization (e.g., temporal vs. non‐temporal lobe epilepsy) as well as extension (i.e., number of epileptogenic regions) might impact the magnitude as well as spatial distribution of subcortical structural changes. Here we used 7 Tesla MRI T1 data to provide an unprecedented description of subcortical morphological (volume, tissue deformation, and shape) and longitudinal relaxation (T1) changes in focal epilepsy patients and evaluate the impact of the EZN and other patient‐specific clinical features. Our results showed variable levels of atrophy across thalamic nuclei that appeared most prominent in the temporal lobe epilepsy group and the side ipsilateral to the EZN, while shortening of T1 was especially observed for the lateral thalamus. Multivariate analyses across thalamic nuclei and basal ganglia showed that volume acted as the dominant discriminator between patients and controls, while (posterolateral) thalamic T1 measures looked promising to further differentiate patients based on EZN localization. In particular, the observed differences in T1 changes between thalamic nuclei indicated differential involvement based on EZN localization. Finally, EZN extension was found to best explain the observed variability between patients. To conclude, this work revealed multi‐scale subcortical alterations in focal epilepsy as well as their dependence on several clinical characteristics.