bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angelica Sinensis Polysaccharide Protects Chondrocytes from Ferroptosis in Osteoarthritis
Authors: Yin Guangrong , Yu Yunyuan , Ni Su , Wang Jiahao , Zhao Chenyu , Xu Chao , Wang Liangliang , Zhou Baojun , Zhao Gongying , Wang Yuji 
Published: July 2023

Abstract
Background
Osteoarthritis (OA) is one of the most common degenerative diseases. Accumulating evidence suggests that ferroptosis may be important in the progression of OA. Angelica Sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses antioxidative, anti-inflammatory and anti-apoptotic properties. However, it is unclear whether ASP can slow down the progression of osteoarthritis by suppressing ferroptosis.
Methods
Collection of postoperative joint cartilage from patients who underwent total knee arthroplasty (TKA), detection of ferroptosis-related markers including glutathione peroxidase 4 (GPX4) and ferritin heavy polypeptide 1 (FTH1) expression, as well as glutathione (GSH) and malondialdehyde (MDA) levels, and investigation of the correlation between ferroptosis and osteoarthritis. Chondrocytes were isolated and cultured, stimulated separately with IL-1β or erastin, rescued by ASP and ferroptosis inhibitors, and changes in cell viability and ferroptosis were detected. A destabilization of the medial meniscus surgical model (DMM) model was established in mice, and ASP was administered orally at different dosages to evaluate its therapeutic effect and level of ferroptosis.
Results
First, the expression of GPX4, FTH1 and reduced GSH was lower while the MDA level was up-regulated in cartilage of the OA group as compared to the control group. Moreover, chondrocyte ferroptosis induced by Erastin or IL-1β was rescued by the application of ASP or ferroptosis inhibitors in vitro. Further, the anti-ferroptotic effect of ASP was related to enhanced nuclear transfer of Nrf2 and decreased activation of NF-κB as indicated by down-regulated expression of p-p65. Next, the in vivo experiments showed that ASP alleviated the cartilage damage of mice joints induced by DMM.
Conclusions
In summary, ASP can attenuate chondrocyte ferroptosis through the Nrf2/NF-κB pathway in the progression of OA, suggesting that ASP may a potential inhibitor of ferroptosis for the treatment of OA.
Association of polymorphism rs74810361 of IP-10 gene with infection of acute respiratory syndrome-corona virus- type 2
Authors: Jandel Farinoosh , Sharifi Zohreh , Nouri Hamid Reza , Khazaili Ali Arab 
Published: July 2023

Abstract
Introduction
CXCL10 is a pro-inflammatory chemokines that have the role in the cytokine storm and the development of severe lung impairment in COVID-19 patients. Considering there have been no studies related to the association of chemokine IP-10 polymorphism with COVID-19, in this study, this association in patients with COVID-19 was compared with healthy blood donors by PCR-RFLP method.
Method:
In this case-control study, 80 COVID-19 infected patients and 80 control donors were selected. After genomic DNA extraction, amplification of the desired gene fragment was done by PCR-method. In order to investigate specified polymorphism, enzymatic digestion with XbaI was done; then the defined bands were detected by electrophoresis. Also, the severity of the disease was analyzed in terms of polymorphism in the subgroup of patients.
Results:
Correlation analysis between the severity of the disease and IP-10 polymorphism, showed that C1596T mutant allele is associated with an increased probability to infect with the severe phase of COVID-19 disease in male patients (p- value=0.02). The presence of T allele in patients with SpO2 <88 compared to patients with SpO2 >88 was also confirmed in these patients significantly (p-value₌ 0.017).
Conclusions:
A significant relationship was observed between the severity of the disease and TT or CT genotype of C1596T polymorphism in the male group. However, there had no significant relationship between the T allele in SNP C1596T and the susceptibility to the covid-19 disease.
Efficacy of Topical Cetirizine 1% in Treatment of Androgenic Alopecia: Clinical and Dermoscopic Evaluation
Authors: Galal Sara , Mahmoud Wafaa , Ahmed Noha 
Published: July 2023

Abstract
Background: Androgenetic alopecia (AGA) is a form of non-scarring scalp hair loss that affects more than 50% of males. Prostaglandins would have an important role in hair growth and their action is variable according to their class. Based on these and the scarce studies that suggest the effectiveness of cetirizine on AGA we carried out this study.
Aim of Work: Dermoscopic evaluation of the efficacy of topical cetirizine 1 % in male patients with androgenetic alopecia.
Materials and methods: A prospective study was carried out on 50 Egyptian male patients treated with topical cetirizine 1% formula once daily. The clinical and dermoscopic examination was done before, during, and after treatment to evaluate the response.
Results: There was a significant increase in the number of terminal hairs, a decrease in the number of vellus hair, and hair diameter diversity after treatment. There was mild to good photographic improvement.
Conclusion: Topical cetirizine 1 % had a promising effect in the treatment of AGA in men after 4 months of treatment. It also is having an excellent safety profile which could be an excellent option in the near future for the patients.
Solutions of some Integro-Differential problems by an anisotropic singular perturbation method
Authors: Benaoudia Djamila 
Published: July 2023

Abstract
The goal of the this note is to study the existence of solutions to some integro-differential problems. Using the singular perturbations method, one can show the existence of such solutions. The perturbed problems are classical, nonlocal, non-linear parabolic problems and the existence of solutions for this problem is insured by the Schauder fixed point theorem. The limit of the solutions of the nonlocal parabolic problem are solutions of the our integro-differential problem.
AMS Subject Classifications: 35K67, 35B40, 35B25, 35K55, 35K15, 45K05.
Surgical Management of Craniospinal Axis Malignant Peripheral Nerve Sheath Tumors: A Single-Institution Experience and Literature Review
Authors: Chowdhury Ajmain , Vivanco-Suarez Juan , Teferi Nahom , Belzer Alex , Al-Kaylani Hend , Challa Meron , Lee Sarah , Buatti John , Hitchon Patrick 
Published: July 2023

Abstract
Background Malignant peripheral nerve sheath tumor (MPNST) is an exceedingly rare and aggressive tumor, with limited literature on its management. Herein, we present our series of surgically managed craniospinal MPNSTs, analyze their outcomes, and review the literature.Methods We retrospectively reviewed surgically managed primary craniospinal MPNSTs treated at our institution between January 2005 and May 2023. Patient demographics, tumor features, and treatment outcomes were assessed. Neurological function was quantified using the Frankel grade and Karnofsky performance scores. Descriptive statistics, rank-sum tests, and Kaplan-Meier survival analyses were performed.Results Eight patients satisfied the inclusion criteria (4 male, 4 female). The median age at presentation was 38 years (range 15–67). Most tumors were localized to the spine (75%), and 3 patients had neurofibromatosis type 1. The most common presenting symptoms were paresthesia (50%) and visual changes (13%). The median tumor size was 3 cm, and most tumors were oval-shaped (50%) with well-defined borders (75%). Six tumors were high grade (75%), and gross total resection was achieved in 5 patients, with subtotal resection in the remaining 3 patients. Postoperative radiotherapy and chemotherapy were performed in 6 (75%) and 4 (50%) cases, respectively. Local recurrence occurred in 5 (63%) cases, and distant metastases occurred in 2 (25%). The median overall survival was 26.7 months. Five (63%) patients died due to recurrence.Conclusions Primary craniospinal MPNSTs are rare and have an aggressive clinical course. Early diagnosis and treatment are essential for managing these tumors. Maximal resection, low-grade pathology, young age (< 30), and adjuvant radiotherapy were associated with improved survival.
TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells
Authors: Perez Rafaela C. , Yang Xenia , Familari Mary , Martinez Gemma , Lovicu Frank J. , Hime Gary R , de Iongh Robb 
Published: July 2023

Abstract
Lens fiber cell differentiation involves a complex interplay of growth factor signals and tight control of gene expression via transcriptional and post-transcriptional regulators. Recent studies have demonstrated an important role for RNA-binding proteins, functioning in ribonucleoprotein granules, in regulating post-transcriptional expression during lens development. Here we have documented the expression of TOB1 and TOB2, members of the BTG/TOB family of RNA-binding proteins, in the developing lens and examine the phenotype of mice that lack Tob1. Both Tob1 and Tob2 mRNA were detected by RT-PCR in epithelial and fiber cells of embryonic and postnatal lenses. By in situ hybridization, Tob1 and Tob2 mRNA were most intensely expressed in the early differentiating fibers, with weaker expression in anterior epithelial cells, and were down-regulated in the germinative zone of E15.5 lenses. TOB1 protein was detected from E11.5 to E16.5 and was predominantly detected in large cytoplasmic puncta in early differentiating fiber cells, often co-localizing with the P-body marker, DCP2. Occasional nuclear puncta were also observed. By contrast, TOB2 was detected in a series of interconnected peri-nuclear granules, in later differentiating fiber cells of the inner cortex. TOB2 did not co-localize with DCP2 but partially co-localized with a marker of stress granules (EIF3B). These data suggest that TOB1 and TOB2 are involved with different parts of the mRNA processing cycle in lens fiber cells. In vitro experiments using rat lens epithelial explants treated with or without a fiber differentiating dose of FGF2 showed that both TOB1 and TOB2 were up-regulated during FGF-induced differentiation. In differentiating explants, TOB1 also co-localized with DCP2 in large cytoplasmic granules. Analyses of Tob1-/- mice revealed relatively normal lens morphology but a subtle defect in cell cycle arrest of some cells at the equator and in the lens fiber mass of E13.5 embryos. Overall, these findings suggest that TOB proteins play distinct regulatory roles in RNA processing during lens fiber differentiation.
PRESTO: A Recommender of Musical Collaborations based on Heterogeneous Graph Neural Networks
Authors: Terroso-Saenz Fernando , Soto Jesus , Muñoz Andres , Roose Philippe 
Published: July 2023

Abstract
The music industry is now more complex and competitive than ever before. In recent years, the search for collaborations with other artists has become a common strategy of musicians to maintain their presence in the sector. Besides, existing music streaming services such as Spotify have exposed large data feeds that can be used to develop innovative services within the realm of music. In this context, the present work introduces PRESTO, a novel recommendation system to suggest musicians new collaborations with other artists by means of an ensemble of Graph Neural Networks. The system is fed with an heterogeneous graph representing the time evolution and the stationary aspects of a musician's career. Finally, the proposal has been evaluated with a dataset comprising more than 200,000 artists, with an average F1 score above 0.75.
Efficient Fuzzy-logic Control of Indoor Mobile Robots Evolving in Static and Dynamic Workspaces
Authors: Hentout Abdelfetah , Maoudj Abderraouf , Kouider Ahmed 
Published: July 2023

Abstract
This paper presents an efficient motion control approach for indoor mobile robots in both static and dynamic workspaces. The proposed system consists of two layers. In the Optimization Layer (Global planner), a Deterministic Constructive Algorithm (DCA) generates the best path for the mobile robot, represented as a set of nodes, to move from the initial position (Source) to the final position (Target) while avoiding the static obstacles. The Control layer (Local planner), which is the main focus of this article, consists of an Efficient Fuzzy-Logic Controller (EFLC), mimicking the human reasoning, to avoid the dynamic obstacles and drive safely the mobile robot along the generated path. The strength of the proposed EFLC approach is shown using V-REP software in dynamic workspaces.
Artificial Intelligence assisted prediction of land surface temperature (LST) based on significant air pollutants over the Annamayya district of India
Authors: Mogaraju Jagadish Kumar 
Published: July 2023

Abstract
Remote sensing (RS), Geographic information systems (GIS), and Machine learning (Artificial Intelligence) can be integrated to predict land surface temperatures (LST) based on the data related to carbon monoxide (CO), Formaldehyde (HCHO), Nitrogen dioxide (NO2), Sulfur dioxide (SO2), absorbing aerosol index (AAI), and Aerosol optical depth (AOD). In this study, LST was predicted using machine learning classifiers, i.e., Extra trees classifier (ET), Logistic regressors (LR), and Random Forests (RF). The accuracy of the LR classifier (0.89 or 89%)is higher than ET (82%) and RF (82%) classifiers. Evaluation metrics for each classifier are presented in the form of accuracy, Area under the curve (AUC), Recall, Precision, F1 score, Kappa, and MCC (Matthews correlation coefficient). Based on the relative performance of the ML classifiers, it was concluded that the LR classifier performed better. Geographic information systems and RS tools were used to extract the data across spatial and temporal scales (2019 to 2022). In order to evaluate the model graphically, ROC (Receiver operating characteristic) curve, Confusion matrix, Validation curve, Classification report, Feature importance plot, and t- SNE (t-distributed stochastic neighbor embedding) plot were used. On validation of each ML classifier, it was observed that the RF classifier returned model complexity due to limited data availability and other factors yet to be studied post data availability. Sentinel-5-P and MODIS data are used in this study.
The Natural Protoalkaloid Methyl-2-Amino-3-Methoxybenzoate (MAM)
Alleviates Positive as well as Cognitive Symptoms in Rat and Mouse
Schizophrenia Models
Authors: Bright Yami , Maas Dorien A. , Verheij Michel M.M. , Paladini Maria S. , Amatdjais-Groenen Helene I.V. , Molteni Raffaella , Riva Marco A. , Martens Gerard J.M. , Homberg Judith R. 
Published: July 2023

Abstract:
The development of new antipsychotics with pro-cognitive properties and less side effects
represents a priority in schizophrenia drug research. In this study, we present for the first time a preclinical
exploration of the effects of the promising natural atypical antipsychotic Methyl-2-Amino-3-
Methoxybenzoate (MAM), a brain-penetrable protoalkaloid from the seed of the plant Nigella damascena.
Using animal models related to hyperdopaminergic activity, namely the pharmacogenetic apomorphine
(D2/D1 receptor agonist)-susceptible (APO-SUS) rat model and pharmacologically induced
mouse and rat models of schizophrenia, we found that MAM reduced gnawing stereotypy and climbing
behaviours induced by dopaminergic agents. This predicts antipsychotic activity. In line, MAM
antagonized apomorphine-induced c-Fos and NPAS4 mRNA levels in post-mortem brain nucleus accumbens
and dorsolateral striatum of APO-SUS rats. Furthermore, phencyclidine (PCP, an NMDA receptor
antagonist) and 2,5-Dimethoxy-4-iodoamphetamine (DOI, a 5HT2A/2C receptor agonist) induced
prepulse inhibition deficits, reflecting the positive symptoms of schizophrenia, which were rescued
by treatment with MAM and atypical antipsychotics alike. Post-mortem brain immunostaining
revealed that MAM blocked the strong activation of both PCP- and DOI-induced c-Fos immunoreactivity
in a number of cortical areas. Finally, during a 28-day subchronic treatment regime, MAM did
not induce weight gain, hyperglycemia, hyperlipidemia or hepato- and nephrotoxic effects, side effects
known to be induced by atypical antipsychotics. MAM also did not show any cataleptic effects. In
conclusion, its brain penetrability, the apparent absence of preclinical side effects, and its ability to antagonize
positive and cognitive symptoms associated with schizophrenia make MAM an exciting new
antipsychotic drug that deserves clinical testing.
Water-Mediated Synthesis, Antibacterial and Antioxidant Evaluation of
New Fused Pyrimido-pyrimidine and Pyrimido-purines Derived From
Nucleobases
Authors: Bouguessa Ichrak , Aber Mohamed , Khier Nawal , Dehamchia Mohamed , Bayou Samir , Régaïnia Zine 
Published: July 2023

Introduction:
A simple and eco-friendly synthesis of novel substituted pyrimido[1,6-
a]pyrimidine, pyrimido[1,2-g]purine, and pyrimido[2,1-e]purine was accomplished by refluxing of nucleobases
(cytosine, adenine or guanine) and dibenzalacetone (DBA) in water using NaOH as a catalyst.

Methods:
The molecular structures of the resulting products were characterized by infrared spectroscopy
(FT-IR), mass spectrometry, and proton (1H) and carbon (13C) nuclear magnetic resonance (NMR).

Results:
The antibacterial activity of the newly fused heterocycles was assayed against the Gram-positive
bacterium Staphylococcus aureus (ATCC 6538) and Gram-negative Escherichia coli (ATCC 8737) using
gentamicin as a standard commercially available antibiotic

Conclusion:
as a standard commercially available antibiotic.
Conclusion: In addition, the antioxidant capacity was screened using the 2,2-diphenyl-2-picrylhydrazyl
hydrate (DPPH•) and the 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS+•)
radicals scavenging assay.
Cognitive training as a technology for protecting and restoring the functions of the central nervous system in patients with infectious pathology
Authors: Khokhlova G. N. , Koltsova O. V. , Isaeva E. R. , Boeva E. V. , Rassokhin V. V. 
Published: July 2023

Many infectious diseases still have medical and social significance, the late detection and untimely treatment of which causes persistent health disorders, leading to early disability. Drug therapy has significantly reduced mortality among people on the background or after infections, increasing the duration and quality of life. However, lesions of the nervous system in human immunodeficiency virus (HIV), viral hepatitis, new coronavirus and other infections, and related neurocognitive disorders cause great concern, are accompanied by complex and clinically important problems.The authors conducted an analytical review of publications and their own research based on the experience of implementing cognitive training in neurocognitive rehabilitation programs that have proven their effectiveness for patients with cognitive disorders against the background of socially significant infections and comorbid conditions.
ANALYSIS OF ASSERTIVE SPEECH ACTS ON KICK ANDY TALK SHOW PROGRAM IN ‘SAVE THE INDONESIAN CHILDREN’ EDITION
Authors: Suryanti Yanti , Irma Cintya Nurika 
Published: July 2023

Abstract: This study intends to describe the assertive speech acts on Kick Andy Talk Show program in ‘Save the Indonesian children’ edition. It is a descriptive qualitative study. The data was collected from the speech containing assertive speech act on the conversation. The method of this research was simak (listening) method. The technique of data collection was documentation in form of video recording, simak bebas cakap (listening without speaking), and catat (field note). Triangulation was used to validate the data. The steps in analyzing the data were data reduction, data display, and conclusion making. The result revealed that there were 56 stating assertive speech acts, 4 complaining assertive speech acts, 4 suggesting assertive speech acts, and no claiming nor bragging assertive speech acts. Keywords: Assertive speech acts, pragmatics, Kick Andy Talk Show Abstrak: Penelitian ini bermaksud untuk mendeskripsikan tindak tutur tegas pada program Kick Andy Talk Show di edisi 'Save the Indonesian Children'. Ini adalah penelitian kualitatif deskriptif. Data dikumpulkan dari pidato yang berisi tindak tutur tegas pada percakapan. Metode penelitian ini adalah metode simak (menyimak). Teknik pengumpulan data adalah dokumentasi dalam bentuk rekaman video, simak bebas cakap, dan catat (catatan lapangan). Triangulasi digunakan untuk memvalidasi data. Langkah-langkah dalam menganalisis data adalah reduksi data, tampilan data, dan pengambilan kesimpulan. Hasil penelitian menunjukkan bahwa ada 56 menyatakan tindak tutur tegas, 4 mengeluh tindak tutur tegas, 4 menyarankan tindak tutur tegas, dan tidak mengklaim atau menyombongkan tindak tutur tegas. Kata kunci: Tindak tutur asertif, pragmatik, Kick Andy Talk Show
THE IMPLEMENTATION OF PROBLEM BASED LEARNING MODEL TO INCREASE STUDENTS’ MATHEMATICAL PROBLEM SOLVING FOR GRADE VIII AT SMP NEGERI 37 MEDAN 2019/2020
Authors: Sitinjak Rosinta Meissi , Simanjuntak Erlinawaty 
Published: July 2023

Abstract: This study aimed to increase students’ mathematical problem solving ability in the numerical pattern material by using problem based learning model in grade VIII of SMP Negeri 37 Medan.. This research was a classroom action research conducted in 2 cycles, each cycle consisted of two meetings, where at the end of each cycle a test of students mathematics problem solving ability (TKPM) was given. The results showed that: in the cycle I, the level of TKPM was moderate with an average value of 68.22, the students who achieved the target of success were 21 students from 32 students (65.625%), in the cycle II the level of TKPM was high with an average value of 80.82, the students who achieved success targets were 28 students from 32 students (87.5%). Based on the those results, it was concluded that the problem-based learning model increased students’ mathematics problem solving ability in class VIII of SMP Negeri 37 Medan in the academic year 2019/2020. Keywords: Problem Based Learning Model, Mathematics Problem Solving Ability Abstrak Penelitian ini bertujuan untuk meningkatkan kemampuan pemecahan masalah matematika siswa dengan menerapkan model pembelajaran berbasis masalah di kelas VIII SMP Negeri 37 Medan. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan dalam 2 siklus, masing-masing terdiri dari dua pertemuan, dimana di akhir setiap siklus diberikan Tes Kemampuan Pemecahan Masalah (TKPM). Hasil penelitian menunjukkan bahwa: Pada siklus I, hasil TKPM siswa adalah sedang dengan nilai rata-rata 68,22, dimana siswa yang mencapai target keberhasilan adalah 21 orang dari 32 orang siswa (65,625%), pada siklus II TKPM siswa adalah tinggi dengan nilai rata-rata 80,82, dimana siswa yang mencapai target keberhasilan adalah 28 orang dari 32 orang siswa (87,5%), Berdasarkan uraian diatas disimpulkan bahwa model pembelajaran berbasis masalah dapat meningkatkan kemampuan pemecahan masalah matematika siswa di kelas VIII SMP Negeri 37 Medan T.A. 2019/2020. Kata Kunci: Model Pembelajaran Berbasis Masalah, Kemampuan Pemecahan Masalah Matematika