bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of CalliSpheres® Microsphere transcatheter-arterial chemoembolization versus conventional TACE in treating renal angiomyolipoma patients
Authors: Lyu Tianshi , Wang Jian , Tong Xiaoqiang , Mi Tianai , An Chao , Zou Yinghua 
Published: August 2023

ABSTRACT

Objective:
Transcatheter-arterial chemoembolization (TACE) is a well-established interventional technique for various tumor treatments, whereas its application in renal angiomyolipoma (RAML) is seldom reported. Conventional TACE (cTACE) with bleomycin–lipiodol emulsion is effective and tolerable for RAML treatment. In this study, we aimed to further explore the efficacy and safety between bleomycin-loaded CalliSpheres® microsphere TACE (CSM-TACE) and cTACE in treating RAML patients.

Methods:
We retrospectively analyzed the data of 54 RAML patients treated by CSM-TACE (n = 17) or cTACE (n = 37). Data on tumor size, tumor volume reduction ratio, patient percentage with tumor size reduction, white blood cells (WBCs), creatinine (Cre) after treatment, complications, and adverse events were retrieved.

Results:
Tumor size (88.66 vs. 81.19 cm3, P = 0.970), patient percentage with tumor size reduction (12 [70.59%] vs. 30 [81.08%], P = 0.486) after treatment, WBCs (P = 0.114), Cre (P = 0.659), and change in Cre after treatment (P = 0.947) were not significantly different between groups, whereas tumor volume reduction ratio was slightly lower in the CSM-TACE group than in the cTACE group (12 ± 34% vs. 32 ± 31%, P = 0.047). The most common postoperative complication was a post-embolization syndrome, including fever, nausea, and abdominal pain, which occurred in 9 (52.94%) and 14 (37.84%) patients from the CSM-TACE and cTACE groups, respectively (P = 0.347).

Conclusion:
CSM-TACE is effective in and well tolerated by RAML patients, implying its potential as an alternative therapy.
Clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas
Authors: Chen Xiao-Yun , Guo Ning-Jing , Guo Pei-Lin , Yang Fan , Luo Qiong , Yang Sheng , Chen Xiang-Qi 
Published: August 2023

ABSTRACT

Objective:
We examined the clinical features and prognosis of advanced intra- and extra-pulmonary neuroendocrine carcinomas (NECs) to offer additional guidance for the clinical treatment of small-cell lung cancer (SCLC), which is a type of advanced intrapulmonary NEC (IPNECs).

Materials and Methods:
The clinical data and survival of 123 patients with advanced IPNECs and extrapulmonary NECs (EPNECs) were obtained. We retrospectively examined the corresponding clinical diagnosis and treatment and investigated the significant factors influencing the survival prognosis of patients with NECs.

Results:
There were 90 cases of IPNECs (including 81 cases of SCLC), and 33 cases of EPNECs. The median overall survival (OS) of IPNECs was significantly longer than that of the EPNECs in the gastrointestinal tract and in the other regions (P < 0.05). The median OS of patients with other IPNECs was longer than that of patients with SCLC (P > 0.05). Multivariate analysis demonstrated that age, liver metastasis, number of cycles of first-line chemotherapy, and chest radiotherapy were risk factors influencing OS in patients with NECs (P < 0.05).

Conclusions:
The survival of IPNECs was significantly longer than that of EPNECs in the gastrointestinal tract and other regions. Nevertheless, patients with advanced NECs who were older and had liver metastases had a poorer prognosis. Multidisciplinary treatments including multicycle chemotherapy and a combination of chemotherapy and radiotherapy should function significantly in extending the survival of NECs.
Bilateral Wilms tumor in a patient with a horseshoe and duplex kidney: A case report
Authors: Wu Xuemin , Du Guoqiang , Liu Zhaoquan , Wu Rongde , Liu Wei 
Published: August 2023

ABSTRACT
The occurrence of horseshoe kidney with duplex urinary collecting systems is rare. Herein, we report a case of bilateral Wilms tumor (BWT) in a patient with a concurrent horseshoe kidney and left duplex kidney, which had not been previously reported. The patient was treated with neoadjuvant chemotherapy, followed by surgical resection and adjuvant chemotherapy. The tumor recurred 6 months postoperatively. A second resection was performed, followed by the administration of chemotherapy and radiotherapy. The patient passed away 15 months after the initial diagnosis of BWT.
Effects of iodine-125 seed brachytherapy on patients with heterochronous pulmonary metastasis from hepatocellular carcinoma: A propensity score matching study
Authors: Yang Chongshuang , He Chuang , Yu Songtao , Yuan Jing , Xiao Yunhua , Huang Xuequan 
Published: August 2023

ABSTRACTPurpose:To investigate the effects of iodine-125 seed brachytherapy (ISB) on the overall survival (OS) of patients with heterochronous pulmonary metastasis (HPM) secondary to hepatocellular carcinoma (HCC).Materials and Methods:The clinical and imaging data of 123 patients with HPM secondary to HCC treated at a single center from July 2012 to July 2020 were analyzed retrospectively. The patients were divided into ISB and non-ISB groups based on ISB treatment. Propensity score matching yielded 46 pairs of patients. A total of 191 lesions were treated, and the data were evaluated for 6 months after ISB. The OS rates of the two groups were compared using theKaplan–Meiermethod. Independent prognostic factors were determined using a Cox proportional hazards regression model.Results:The percentages of lung lesions in complete remission, partial remission, disease stable, and disease progression stages were 49.2%, 32.8%, 9.6%, and 8.4%, respectively. The disease control rate was 91.6%. The median follow-up time from the initial diagnosis was 47 months and 33 months for the ISB and non-ISB groups, respectively. Patients in the ISB group had a longer OS than those in the non-ISB group (1-year: 95.7% vs. 80.3%; 3-year: 62.9% vs. 45.7%; 5-year: 37% vs. 20.9%;P< 0.05). Multivariate analysis demonstrated that ISB treatment, tumor differentiation, vascular invasion, and Child − Pugh score were independent prognostic factors for survival.Conclusion:ISB improves local control and OS rates of HPM secondary to HCC; thus, it is an effective and feasible option for patients with HPM secondary to HCC.
Undiagnosed hypertension and associated factors among adults in the urban field practice area of AIIMS Raipur: A community-based screening survey
Authors: Krishna Ekta , Pal Anjali , Galhotra Abhiruchi , Shukla Arvind Kumar , Parija Pragyan Paramita , Pathak Vineet Kumar , Rajath Rao UR , Naik Bijaya Nanda 
Published: August 2023

Introduction:
Undiagnosed hypertension (HTN) increases the risk of severe consequences such as chronic kidney disease (CKD), hypertensive retinopathy, heart failure, and stroke. Population-based screening can be used to expose the hidden diseased mass with active disease. Thus, a screening survey was conducted to estimate the proportion of people with HTN among apparently healthy adults of age ≥30 years residing at the urban field practice area (UHTC) of AIIMS, Raipur, and also determine the predictors of undiagnosed HTN among the study participants.

Methodology:
This was a community-based cross-sectional study conducted over 2 months duration in the Ramnagar area, which comes under the urban field practice area of AIIMS Raipur using the STEPS tool is an acronym of study tool provided by WHO i.e. STEPwise approach to NCD risk factor surveillance consisting of three steps viz. questionnaire for behavioural risk factors, physical measurements and biochemical measurements.

Results:
In this study, 24.2% (95%, confidence interval [CI]: 20.1–28.2) of participants screened positive for HTN. The proportion of males who screened positive for HTN was 28.8% (95% CI: 22.6–35), whereas the proportion of females who screened positive for HTN was 19.6% (95% CI: 14.3–25). In this study, elderly (>60 years), male gender, daily tobacco use, greater waist circumference (male >90 cm and female >80 cm), and daily salt intake of more than 5 g were found to have higher odds of having HTN.

Conclusion:
The prevalence of undiagnosed HTN in the UHTC of AIIMS Raipur was quite high.
Knowledge of schoolteachers on learning disabilities in urban Vellore - A cross-sectional study
Authors: Jebakumar Daniel , Marconi Sam , Kattula Dheeraj , Priscilla Ruby A. 
Published: August 2023

Background:
Specific learning disability (SLD) is a cognitive neurobiological disorder caused by atypical brain functioning. SLD is recognized when the individual’s achievement in school is below that expected for age, schooling, and level of intelligence. Screening millions of students with SLD by health personnel is a logistical impossibility. Awareness and knowledge about learning disorders among schoolteachers may play a major role in the early identification and management of children with these disorders. Therefore, the assessment of teachers’ knowledge and perceptions about learning disabilities (LDs) is relevant.

Method:
A school-based cross-sectional study was conducted among teachers in government/government-aided and private schools in Vellore, India. The participants were selected by a simple random sampling method. There was a total of 80 teachers included in the study. Data capture was done using a questionnaire. A Chi-square test was done to test the association and the odds ratio test helped determine the strength of the association. A P-value of <0.05 was considered to be statistically significant.

Results:
The majority of the teachers (70%) had adequate general knowledge regarding LDs. When analyzed separately, 82.5% of government/aided teachers and only 57.5% of teachers were having adequate general knowledge regarding LDs. There was a significant association between the type of school and general knowledge regarding LDs. Government/aided teachers had better general knowledge regarding LDs and dyslexia than private teachers.

Conclusions:
Among 80 teachers, 70% (56) of them had adequate general knowledge regarding LDs. When analyzed separately, 82.5% (33) of government/aided teachers and only 57.5% (23) teachers were having adequate general knowledge regarding LDs. The government/aided schoolteachers had significantly higher levels of knowledge in most domains of the general knowledge section as compared to private schoolteachers. If teachers are having adequate knowledge regarding LDs, it will significantly increase the chances of children with LDs getting detected early and undergoing the treatment they require. Teacher education programs and workshops are needed to be conducted at regular intervals to improve the knowledge regarding SLDs among teachers.
Clinical profile of hospitalised moderate category COVID-19 patients: Short study from a Tertiary Care Centre in Delhi
Authors: Gautam Sachin , Kumar Rahul , Bhadoria Dharam Pal , Mawari Govind , Kumar Naresh , Daga Mradul K. , Pandit Sanjay , Anuradha S. , Pradhan Gaurav Shanker , Garg Sandeep , Sharma Gaurav , Raghu RV , Ritchie Nupur , Jayamsulekha Dasari 
Published: August 2023

Background:
The clinical profile of hospitalized moderate-category COVID-19 patients has been understudied globally and in India.

Aim:
The present study was conducted to study the clinical profile and assess the proportions of patients who progressed to severe disease and its predictors among moderate COVID-19 patients.

Materials and Methods:
In this single-center observational study, 100 moderate-category COVID-19 patients as per Ministry of Health and Family Welfare (MoHFW) criteria of age ≥18 years of either sex, excluding pregnant females from February to November 2021, were studied by analyzing their clinical profiles and assessing Quick Sequential Organ Failure Assessment (qSOFA), National Early Warning Score 2 (NEWS-2), and chest computed-tomography severity score (CTSS) to predict progression to severe disease. Severe disease was defined as per MoHFW criteria.

Results:
Out of 100 moderate-category COVID-19 patients, progression to severe disease was seen in 11 patients (11%), among which eight patients had expired, three patients were discharged, and the rest of the 89 patients (89%) who did not progress to severe disease were discharged. A higher age (62.2± 19.5 vs 54.8 ± 14.6 years), along with multivariate analysis revealing male sex (1.25 times), chronic kidney disease (2.86 times), leukocytosis (6.10 times), thrombocytopenia (1.04 times), anemia (9.3 times), a higher qSOFA score (3.6 times), and a higher NEWS-2 score on admission (1.56 times) had higher odds of progression to severe disease. A significant correlation (P < .05) of qSOFA score with serum LDH, ferritin, and hs-CRP levels; CT severity score with the serum ferritin, IL-6, and LDH levels; and NEWS-2 with serum LDH, hs-CRP, and ferritin levels were found. Moreover, the NEWS-2 score was found slightly better than qSOFA on receiver operating characteristic (ROC) curve analysis, with an area under the curve of 85.8% and 83.2%, respectively, predicting progression to severe disease.

Conclusion:
Our study revealed male gender, chronic kidney disease, leukocytosis, anemia, thrombocytopenia, a higher qSOFA and NEWS-2 score on admission, and further, NEWS-2 score better than qSOFA on ROC curve analysis, with an area under the curve of 85.8% and 83.2%, respectively, in predicting severe disease among hospitalized moderate COVID-19 patients.
Haematological screening and its correlation with sociodemographic profile among the indigenous communities in and around Puducherry
Authors: Kar Rakhee , Anand Jeyanthi , Kar Sitanshu Sekhar , Banu Narkiss , Kuppusamy Dheebika , Sivanantham Parthibane , Bhattacharyya Maitreyee 
Published: August 2023

Background:
Haemoglobin disorders are unique and important health challenges for tribal populations. Hence, this study was undertaken with the aim to screen for haematological disorders, particularly anaemia and haemoglobinopathies, and to assess the sociodemographic profile in indigenous communities residing in and around Puducherry.

Methods:
This was a community-based cross-sectional study conducted in both urban and rural areas of Puducherry district. We included 556 participants through convenient sampling. Trained research associates visited community to enrol eligible participants and sought information on sociodemographic parameters, health status, and disease profile, using a structured questionnaire; 2–3 ml of blood was collected in ethylene diamine tetra acid anticoagulant for analysis of haematology parameters.

Results:
Median age of participants was 28 (17–42) years. Majority (58.8%) of the participants were female, married (52.8%). On thalassemia screening, none of the study participants had any haemoglobinopathy. The burden of anaemia among the study population was 38.7% (95% CI: 34.6–42.8%) and was higher among the female participants in both adolescent (54.5%) and adult (57.8%) age groups. The next common haematological abnormality observed was eosinophilia 21.4% (95% CI: 18–25%), more prevalent among males in the age group of 30–60 years.

Conclusion:
More than half of the women were anaemic. Multidimensional planning and implementation are needed to improve the socio-economic profile and overall health of this vulnerable population.
Evaluation of community-based care delivered by primary healthcare providers in management of hypertension in a rural area of West Bengal
Authors: Mukhopadhyay Prianka , De Maumita , Lahiri Surajit , Sarkar Manisha , Haldar Anima 
Published: August 2023

Background:
Lifestyle modifications and medication compliance are key strategies.

Objectives:
To evaluate the effect of community-based care delivered by trained primary healthcare providers in management of hypertension.

Materials and Methods:
A longitudinal study was conducted between two groups of newly diagnosed hypertensive patients to evaluate the impact of an educational intervention. Six blocks in a district were chosen with pairwise matching. All primary healthcare providers of one block in each pair were randomized to receive the intervention and the other was controlled. Next screening for risk factors, detection of hypertension, counseling, and follow-up care were provided. The patients within the control group received usual care as per clinician’s discretion. A total of 227 patients in the “study” group and 230 patients in the “control” group were recruited from 12 subcenters selected randomly. Data analysis was done by χ2 test, t test, and GLM analysis using SPSS 16.

Results:
Patients in the intervention blocks demonstrated a statistically significant mean reduction in SBP of 16.14 ± 0.82 and DBP by 11.65 ± 0.53 compared to 9.83 ± 1.02 and 7.68 ± 0.66, respectively, in the control blocks after adjusting for age, sex, and baseline blood pressure at one-year follow-up. Regarding lifestyle-related cardiovascular risk factors, statistically significant differences were found in favor of the intervention group.

Conclusion:
The study supports and reinforces the utilization of trained primary healthcare providers under the NPCDCS program in screening and promoting blood pressure control by preventive services to hypertensive patients in the community.
A cluster onset of acute and accelerated silicosis cases in workers of ramming mass industries in Jharkhand, Eastern India
Authors: Singh Dharmendra , Carr Samit Kumar , Sarkar Bidisa , Ali Syed Irfan , Sarkar Kamalesh 
Published: August 2023

Introduction and Methodology:
A cross-sectional study was conducted among workers of ramming mass industries in the East Singhbhum district of Jharkhand, eastern India. Workers had occupational exposure to respirable crystalline silica dust of varied duration between 1 and 6 years. A total of 122 subjects participated in it. Relevant epidemiological information was collected from them. All were x-rayed using 300 mA radiation for the detection of the presence of silicotic opacities if any as described by the International Labour Organisation (ILO) for the detection of silicosis.

Results:
The study revealed that 61.4% (n = 75) of subjects had silicosis. Of them, 19 had acute silicosis (having a duration of silica dust exposure of 2 years or lesser) and 56 had accelerated silicosis (a duration of occupational exposure of > 2 to 6 years). The offending agent was clouds of respirable crystalline silica dust from the ramming mass industries.

Epidemiological Interpretation:
To the best of our knowledge, this is the first report of an outbreak of acute and accelerated silicosis cases because of occupational inhalational exposure to ramming mass in India with a sizable portion of female workers with silicosis. Regional as well as national authorities need to take appropriate interventional measures in a programmatic mode as soon as possible.

Conclusion:
An in-depth investigation on the existence and magnitude of the problem of silico-tuberculosis is needed to be performed in them as silicosis increases the vulnerability of pulmonary tuberculosis among the affected workers.
Prevalence of work-related musculoskeletal disorders (WRMSDs) and its association with modifiable risk factors in metropolitan bus transit drivers: A cross-sectional comparison
Authors: Sheth Ankit , Pagdhune Avinash , Viramgami Ankit 
Published: August 2023

Background:
Bus drivers are one of the top three occupations with the highest prevalence of work-related musculoskeletal disorders (WRMSDs). The present study aimed to determine the pattern and prevalence of WRMSD among metropolitan bus transit drivers, whose job profiles differ from traditional long-distance bus drivers, and to explore the effect of modifiable lifestyle-related risk factors.

Materials and Methods:
In this cross-sectional study, consenting 254 metropolitan transit bus drivers (with at least five years of job duration) and 73 age-matched indoor desk job workers (administration staff of the same department) as a comparison group enrolled. Sociodemographic and occupational profile were collected on a semi-closed questionnaire. A modified Nordic questionnaire was used to determine musculoskeletal problems. Anthropometric measurement and haematocrit estimation were performed with standard techniques. All statistical analyses including logistic regression were performed with SPSS 26.0.

Results:
The prevalence of WRMSDs among bus drivers was twice higher than administration staff (49.2% v/s 28.8%). Drivers experienced significantly higher pain for the lower back (36.6% v/s 11%), knee (29.5% v/s 15.1%), and hip (7.5% v/s 1.4%) in comparison with administration staff. Study reported age, tobacco usage, body mass index (BMI) and job profile of drivers (compared to administration staff) as significant predictors of WRMSDs.

Conclusion:
WRMSDs were significantly higher among metropolitan bus transit drivers in comparison with administrative staff. Furthermore, WRMSDs are strongly associated with tobacco use and BMI. These modifiable risk factors may be the targets for preventive strategies to reduce the burden of WRMSDs among bus drivers.
An educational intervention study to enhance breast cancer awareness among women and primary healthcare providers of an urban health center area, Visakhapatnam
Authors: Potluri Tanmayee S. , Vadlamani Sarada , Gujjarlapudi Chaitanya , Nerusu Nagamani G. , Rongala Manasa V. 
Published: August 2023

Background:
Breast cancer is the most common malignancy in women worldwide posing greater health challenge. The poor survival rate from breast cancer in India may be attributed to lack of awareness, low rate of screening uptake and presentation of cases in advanced stage.

Objectives:
To assess the baseline knowledge and effectiveness of educational intervention in improving the knowledge regarding breast cancer.

Materials and Methods:
A quasi-experimental community-based health educational intervention study was performed among 100 women and 18 female primary healthcare providers residing in urban field practice area. Face-to-face interviews were performed using a questionnaire adapted from the Breast Cancer Awareness Measure (Breast-CAM) Version 2. Data were analyzed using SPSS version 25. To assess the difference between pre- and postintervention scores, Mc-Nemar’s test and paired sample t tests were applied. Association between socio-demographic variables and difference in mean scores was assessed by using ANOVA and independent t test. P value less than 0.05 was taken as statistically significant.

Results:
The mean pre-intervention score of knowledge items (21 including warning signs, risk factors of breast cancer) among 100 women participants was 7.19 ± 3.45 and postintervention mean score was 18.18 ± 2.42. The mean pre-intervention score among 18 primary healthcare providers was 10.89 ± 4.59 and postintervention score was 19.89 ± 1.28. There was significant improvement in mean scores. The increase in percentage of scores in all 21 items postintervention was significant (Mc-Nemar’s test). There was significant association between socio-demographic profile and increase in mean scores. The study identified various barriers for seeking medical care among women.

Conclusion:
The community-based educational intervention was effective in enhancing the knowledge regarding breast cancer among women.