bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-situ growth of nitrogen-doped carbon nanotubes on MXene nanosheets for efficient sodium/potassium-ion storage
Authors: Wang Tao , Zeng Jinjue , Gu Xianrui , Meng Yuhang , Yang Han , Zhu Hongda , Deng Dingfei , Sun Zhipeng , Ding Rui , Li Yongle , Rong Junfeng , Wang Xuebin 
Published: May 2023

For game changing for future of large-scale energy storage technologies, sodium-ion and potassium-ion batteries provide a substitute to lithium-ion batteries. As an excellent candidate anode, MXene still suffers from the blockage of active sites caused by restacking of sheets. Herein, an in-situ decoration of MXene nanosheets with nitrogen-doped carbon nanotubes (CNTs) is introduced, to yield MXene@CNTs. The modification of nitrogen-doped CNTs not only prevents the restacking of MXene and increases ion accessibility but also improves the electrode’s overall conductivity, thereby enhancing electron conduction and ion diffusion kinetics significantly. Therefore, MXene@CNTs exhibits superior sodium/potassium-ion storage performance than pure MXene nanosheets. At 0.05 A g-1, it can deliver reversible capacities of 286 mAh g-1 for SIBs and 250 mAh g-1 for PIBs. This research illustrates the significance of the electrode architecture for electrochemical performances, and the in-situ growth strategy could provide some insight on searching for high-performance MXene-based anodes for SIBs and PIBs.
FindMyApps eHealth intervention improves quality, not quantity, of home tablet use by people with dementia
Authors: Neal David P. , Kuiper Leanne , Pistone Daniela , Osinga Channah , Nijland Sanne , Ettema Teake , Dijkstra Karin , Muller Majon , Dröes Rose-Marie 
Published: May 2023

IntroductionFindMyApps is a tablet-based eHealth intervention, designed to improve social health in people with mild dementia or mild cognitive impairment.MethodsFindMyApps has been subject to a randomized controlled trial (RCT), Netherlands Trial Register NL8157. Following UK Medical Research Council guidance, a mixed methods process evaluation was conducted. The goal was to investigate the quantity and quality of tablet use during the RCT, and which context, implementation, and mechanisms of impact (usability, learnability and adoption) factors might have influenced this. For the RCT, 150 community dwelling people with dementia and their caregivers were recruited in the Netherlands. For the process evaluation, tablet-use data were collected by proxy-report instrument from all participants' caregivers, FindMyApps app-use data were registered using analytics software among all experimental arm participants, and semi-structured interviews (SSIs) were conducted with a purposively selected sample of participant-caregiver dyads. Quantitative data were summarized and between group differences were analyzed, and qualitative data underwent thematic analysis.ResultsThere was a trend for experimental arm participants to download more apps, but there were no statistically significant differences between experimental and control arm participants regarding quantity of tablet use. Qualitative data revealed that experimental arm participants experienced the intervention as easier to use and learn, and more useful and fun than control arm participants. Adoption of tablet app use was lower than anticipated in both arms.ConclusionsA number of context, implementation and mechanism of impact factors were identified, which might explain these results and may inform interpretation of the pending RCT main effect results. FindMyApps seems to have had more impact on the quality than quantity of home tablet use.
Suspected cutaneous adverse drug reactions reported with traditional medicines: analysis of data for United Nations Asia region from WHO VigiBase
Authors: Barvaliya Manish J. , Chetan A. C. , Chandan N. , Ray Suman Kumar , Hegde Harsha V. , Unger Banappa S. , Patel Tejas K. , Roy Subarna 
Published: May 2023

Background: Data on traditional medicine-induced cutaneous adverse drug reactions (ADRs) is very scarce. The current secondary analysis based on the WHO database (VigiBase) of individual case safety reports (ICSRs) focuses on the suspected cutaneous ADRs linked to traditional medicines (TMs).Methods: All the ICSRs reported between 1st January 2016 and 30th June 2021 from the UN Asia region in VigiBase where at least one TM was suspected to cause cutaneous ADRs were included in the study. Data regarding demographic details, suspected drug, adverse reaction as per MedDRA term, the seriousness of the reaction, de-challenge, re-challenge, and clinical outcome for suspected cutaneous ADRs associated with TM were obtained from VigiBase and analyzed for frequency of reported events and suspected medicines.Findings: Total 3,523 ICSRs with 5,761 ADRs related to “skin and subcutaneous tissue disorders” were included in the analysis. Amongst these, 6.8% of ICSRs were reported as serious. Pruritus (29.6%), rash (20.3%), urticaria (18.9%), and hyperhidrosis (3.3%) were commonly reported ADRs. Artemisia argyi H.Lév. and Vaniot. (14.9%), Ginkgo biloba L. (5.1%), Vitis vinifera L. (4%), Vitex agnus-castus L. (3.8%), Silybum marianum (L.), Gaertn (3.5%), and Viscus album L. (2.7%) were some commonly suspected TMs for cutaneous ADRs. There were 46 cases of Stevens-Johnson syndrome and toxic epidermal necrolysis reported with TMs during the study period. Death was reported in 5 ICSRs.Interpretation: TMs are linked with various cutaneous ADRS ranging from pruritus to toxic epidermal necrolysis which may have serious consequences. TMs listed as suspected offending agents in this analysis, should be kept in mind while dealing with suspected cutaneous ADRs. Clinicians should be more vigilant in detecting and reporting events associated with TMs.
Effects of short-term extreme temperature treatment on the development and reproductive capacity of Encarsia formosa
Authors: Li Ming-Jiang , Zhang Bo , Chen Guo-Hua , Zhou Shun-Wen , Liu Ji-Huan , Lu Mei , Zhang Jin-Long , Yang Shao-Wu , Zhang Xiao-Ming 
Published: May 2023

Encarsia formosa is a natural enemy of the invasive pest Bemisia tabaci and is known to be a dominant parasitic. The frequency and magnitude of climate extremes, particularly temperature extremes, have increased, which has put insect populations at risk. However, the effects of temperature extremes on E. formosa are not well understood. To examine the impact of short-term extreme temperature exposure on the development and reproduction of E. formosa, eggs, larvae, pupae, and adults were exposed to high/low temperature treatments (HLT25, HLT50, LLT25, and LLT50). Our findings indicate that the pupal stage of E. formosa exhibited the strongest tolerance to both heat and cold, while adults exhibited a weaker tolerance. The shortest egg-to-adult development period of 12.65 days was observed in E. formosa exposed to HLT50 treatment during the egg-larval stage. The parasitism peak of the adult stage was delayed by 1–6 days after exposure to extreme temperatures during the egg-larval stage. Conversely, the parasitism peak was advanced by 1–3 days after exposure to extreme temperatures during the pupal and adult stages. The eclosion rate, total parasitism, eclosion rate of the F1 generation, and adult longevity of the F1 generation were lower in the treatment groups than in the control groups. The F1 generation’s development period was prolonged to 15.49 and 15.19 days after exposure to HLT25 and HLT50 treatments, respectively, during the egg-larval stage. The F1 generation’s development period was shortened to 13.33 days after exposure to LLT50 treatment during the pupal stage. Male individuals appeared in the F1 generation after exposure to HLT50 treatment during the pupal stage, with females accounting for only 56.38%. Our results demonstrate that short-term exposure to extreme temperatures has detrimental effects on the growth and reproduction of E. formosa. In field biocontrol against E. formosa, the release of E. formosa should be avoided as much as possible when the ambient temperature is higher than 35°C or lower than 0°C. During extreme temperature conditions, timely supplementation and release of E. formosa population, along with ventilation and cooling in greenhouse facilities during summer, are necessary for better pest control efficacy.
Virulent and attenuated strains of Trichoderma citrinoviride mediated resistance and biological control mechanism in tomato
Authors: Zhao Di , Shen Dan , Fan Haiyan , Zhu Xiaofeng , Wang Yuanyuan , Duan Yuxi , Chen Lijie 
Published: May 2023

IntroductionRoot-knot nematode disease is one of the world's most serious vegetable crop diseases. In recent years, Trichoderma spp. has been widely used in root-knot nematode disease control as a biological control agent.MethodsVirulent and attenuated strains of Trichoderma citrinoviride mediated resistance and biological control mechanism in tomato were determined.ResultsPreliminary experiments found differences in nematicidal virulence among Trichoderma citrinoviride. The 24-hour corrected mortality rate of the virulent strainT1910 was as high as 92.37%, with an LC50 of 0.5585 against the second juveniles (J2s) of Meloidogyne incognita. And the attenuated strain TC9 was 23.01%, the LC50 was 2.0615, so the virulent strain T1910 had a more substantial effect on the J2s than the attenuated strain. We found that the strong virulent strain T1910 have a good control effect on M. incognita by the pot experiment of tomato than that of the attenuated virulent strain TC9,especially the J2 and J4 numbers were inhibited inside the root knots of tomato. Theinhibition rates of virulent strains reached 85.22% and 76.91%, followed by attenuatedstrain TC9, which were 63.16% and 59.17%, respectively. To reveal the differences intomato defense pathways induced by different virulent strains, qRT-PCR was further usedto detect changes in the expression of inducement-related genes. The results showed thatthe TC9 was significantly upregulated at 5dpi, LOX1, PR1, and PDF1.2. The PR5 gene ofthe virulent strain T1910 was highly upregulated, and the JA pathway was activated laterbut weaker than the attenuated strain. The results of this study revealed that thebiocontrol mechanism of T. citrinoviride as poison killing through the virulent strain T1910 and induced resistance to M. incognita through attenuated strain, although virulence degradation also has an induced resistance effect. Moreover, the attenuated strain TC9 stimulated tomato immune response earlier than the virulent strain by nematode-associated molecular pattern-triggered (NAMP).DiscussionTherefore, the research elucidated the mechanism of multiple control of Trichoderma spp. against M. incognita.
Four years after the implementation of antimicrobial stewardship program in Jordan: evaluation of program’s core elements
Authors: Hassan Samar Khaled , Dahmash Eman Zmaily , Madi Thaira , Tarawneh Omar , Jomhawi Tuqa , Alkhob Worood , Ghanem Rola , Halasa Zina 
Published: May 2023

ObjectivesTo combat antimicrobial resistance, the World Health Organization (WHO) urged healthcare organizations in Low- and Middle-Income Countries (LMICs) to implement the core elements of the antimicrobial stewardship (AMS) programs. In response, Jordan took action and developed a national antimicrobial resistance action plan (NAP) in 2017 and commenced the AMS program in all healthcare facilities. It is paramount to evaluate the efforts to implement the AMS programs and understand the challenges of implementing a sustainable and effective program, in Low-Middle Income Country (LMIC) contexts. Therefore, the aim of this study was to appraise the compliance of public hospitals in Jordan to the WHO core elements of effective AMS programs after 4 years of commencement.MethodsA cross-sectional study in public hospitals in Jordan, using the WHO AMS program core elements for LMICs was carried out. The questionnaire comprised 30 questions that covered the program’s six core elements: leadership commitment, accountability and responsibility, AMS actions, education and training, monitoring, and evaluation, and reporting and feedback. A five-point Likert scale was employed for each question.ResultsA total of 27 public hospitals participated, with a response rate of 84.4%. Adherence to core elements ranged from (53%) in the leadership commitment domain to (72%) for AMS procedure application (actions). Based on the mean score, there was no significant difference between hospitals according to location, size, and specialty. The most neglected core elements that emerged as top priority areas were the provision of financial support, collaboration, access, as well as monitoring and evaluation.ConclusionThe current results revealed significant shortcomings in the AMS program in public hospitals despite 4 years of implementation and policy support. Most of the core elements of the AMS program were below average, which requires hospital leadership commitment, and multifaceted collaborative actions from the concerned stakeholders in Jordan.
Relative Controllability of ψ-Caputo Fractional Neutral Delay Differential System
Authors: Muthuvel Kothandapani , Sawangtong Panumart , Kaliraj Kalimuthu 
Published: May 2023

The aim of this work is to analyze the relative controllability and Ulamn–Hyers stability of the ψ-Caputo fractional neutral delay differential system. We use neutral ψ-delayed perturbation of the Mitttag–Leffler matrix function and Banach contraction principle to examine the Ulam–Hyers stability of our considered system. We formulate the Grammian matrix to establish the controllability results of the linear fractonal differential system. Further, we employ the fixed-point technique of Krasnoselskii’s type to establish the sufficient conditions for the relative controllability of a semilinear ψ-Caputo neutral fractional system. Finally, the theoretical study is validated by providing an application.
Biochemical aspects of magnesium-enhanced bone regeneration
Authors: Baraeva L. M. , Baida A. Sh. , Bykov I. M. , Kurzanov A. N. , Tsymbalov O. V. , Pavlyuchenko I. I. , Storozhuk A. P. 
Published: May 2023

Current research is focused on practical implications of magnesium-based implants largely due to their biodegradability and ability to promote bone healing and formation. However, the mechanism underlying the osteogenesis regulation by magnesium is still unclear.We describe cellular and molecular mechanisms underlying the effect of magnesium ions (Mg2+) on bone growth following the device implantation. The presented data demonstrate magnesium-induced activation of canonical Wnt/β-catenin signaling pathway in human bone marrow stromal cells resulting in their differentiation into osteoblasts, osteogenic effect and recovery of bone defects. We describe the role of the molecular mechanisms responsible for osteopromotive properties of Mg2+ and associated with unique transient receptor potential melastatin 7 (TRPM7) cation channels mediating the Mg2+ influx. TRPM7-mediated Mg2+ influx is important for platelet-derived growth factor (PDGF)-induced proliferation, adhesion, and migration of human osteoblasts, as well as for promotion of Mg2+-associated bone regeneration.We discuss the effect of Mg2+ on intracellular signaling processes, expression of the vascular endothelial growth factor (VEGF), hypoxia-inducible factor-2α, and peroxisome proliferator-activated receptor-γ coactivator 1α. Mg2+ can promote bone regeneration by enhancing the production of type X collagen and VEGF by osteogenic cells in bone marrow.
Analysis of ultrasonography and cytology potential in differential diagnosis of major salivary gland neoplasms
Authors: Polshikov S. V. , Katrich A. N. , Vetsheva N. N. 
Published: May 2023

Background: Salivary gland tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is one of the main diagnostic modalities for the salivary gland pathology; however, its diagnostic potential is under scrutiny. Fine needle aspiration cytology is considered the main diagnostic method, although its role in the differential diagnosis is disputable.Objective: To identify, based on morphology results, the effectiveness of the main ultrasonographic signs indicating major salivary gland neoplasms in the differential diagnosis and study these signs, to evaluate the effectiveness of fine needle aspiration in the diagnosis of benign and malignant major salivary gland neoplasms.Materials and methods: This retrospective study evaluated a group of 220 patients. We calculated sensitivity, specificity, and accuracy of qualitative ultrasonographic signs of salivary gland neoplasms, analyzed the fine needle aspiration effectiveness, and compared results accuracy by calculating Pearson’s empirical χ-square.Results: Common ultrasonographic signs of benign salivary gland neoplasms included a clear contour (97.5%) and decreased echogenicity (72.7%). Malignant tumors frequently presented with a clear contour (76.7%), uneven contour (72.1%), and decreased echogenicity (69.8%). Fine needle aspiration sensitivity and specificity in the diagnosis of benign neoplasms were 75.5% and 53.6%, respectively. Fine needle aspiration sensitivity and specificity in respect of malignant tumors were 50% and 94%, respectively. Pearson’s χ-square value for the clear contour had significant differences in favor of benign neoplasms.Discussion: Benign and malignant salivary gland neoplasms often have a similar ultrasonographic pattern. A significant diagnostic sign of malignant tumors is the uneven contour. We compared the effectiveness of cytological differentiation between benign and malignant neoplasms and found high rates of specificity and accuracy for malignant tumor diagnosis.Conclusions: Clear contour and decreased echogenicity are significant ultrasonographic signs in the differentiation of benign neoplasms. Uneven contour is a significant differentiating factor for malignant neoplasms. Cytology can be used for initial morphology in diagnosing major salivary gland neoplasms, but in half of the cases it fails to identify the nature and type of the tumor.
Identifikasi Cemaran Tembaga Cu Pada Makanan Dan Minuman
Authors: Utami Marsah Rahmawati , Nurfadhila Lina , Iskandar Putri Mutiara , Maharani Sekar Ayu , Aryani Ajeng Nita 
Published: May 2023

Tembaga (Cu) adalah logam dengan nomor atom 29, massa atom 63,546, titik lebur 1083 °C, titik didih 2310 °C, jari-jari atom 1,173 A° dan jari-jari ion Cu2+ 0,96 A°. Tembaga adalah logam transisi (golongan I B) yang berwarna kemerahan, mudah regang dan mudah ditempa. Tembaga (Cu) juga merupakan logam berat golongan essensial, namun dalam konsentrasi tinggi dapat menyebabkan toksisitas seperti nekrosis hati. Sehingga yang perlu dilakukan adalah menjaga agar konsentrasi tembaga di dalam tubuh tidak melebihi ambang batas normal. Logam berat merupakan salah satu sumber pencemar terhadap makanan dan minuman. Metode penelitian yang digunakan yaitu menggunakan metode studi literature dalam bentuk referensi berupa jurnal nasional 10 tahun terakhir yang dicari pada database Google Scholar dengan bahan acuan 15 jurnal yang berkaitan dengan Identifikasi Cemaran Tembaga Cu Pada Makanan Dan Minuman. Berdasarkan studi literatur didapatkan hasil bahwa setiap sampel uji positif mengandung tembaga (cu).
Kata Kunci : Tembaga, Cu, Logam
Elastomer-coated graphene biosensor and its response to enzymatic reactions
Authors: Ono Takao , Kannaka Miho , Kanai Yasushi , Miyakawa Naruto , Shinagawa Ayumi , Nakakita Shin-ichi , Watanabe Yohei , Ushiba Shota , Tani Shinsuke , Suzuki Yasuo , Kimura Masahiko , Chiba Daichi , Matsumoto Kazuhiko 
Published: May 2023

Abstract
Graphene biosensors have the potential to be excellent applications of two-dimensional materials, because graphene has high mobility and specific surface area. However, it is difficult to stably obtain consistent responses from graphene biosensors owing to external disturbances and the lack of understanding their sensing mechanism. We propose a graphene biosensor coated with a gas-permeable silicone elastomer, poly(dimethylsiloxane). The elastomer coating allows only the gas molecules to reach the graphene surface, suppressing the disturbances from other factors, and thereby eliciting stable responses to target ammonia molecules in solution. It allowed us to clarify the relationship between ammonia production via urease reactions and conductivity changes of the graphene biosensor. The biosensor responses were modeled using the combination of the dissociation equilibrium of ammonia, Langmuir’s adsorption isotherm, and Michaelis–Menten equation. Findings of this study lay the foundation for practical applications of stable graphene biosensors based on our reasonable response model.
ANALISIS UKURAN PERUSAHAAN, FCF DAN KEBIJAKAN HUTANG TERHADAP KINERJA KEUANGAN PERUSAHAAN FOOD AND BEVERAGE
Authors: Gusmao Eunike Frentelina 
Published: May 2023

The purpose to be achieved in this study is to empirically examine the influence of variables in Company Size, Free Cash Flow, and Debt Policy on Financial Performance on Food and Beverage companies listed on the Indonesia Stock Exchange. The period used in this study is 4 (four) years, which is from 2017 to 2020. The population used in this study were 30 food and beverage companies that have been and are still listed on the Indonesia Stock Exchange in 2017-2020. The sampling technique was purposive sampling so that it is obtained by as many as 20 companies. The data analysis technique was multiple linear regression. The results of this study showed that the size of the company had a significant effect on the company's financial performance, Free Cash Flow also had a significant effect on financial performance,Â while for debt policy represented by DER has an insignificant effect on financial performance.
Tinjauan Fiqh ‘Urf Terhadap Praktik Perjanjian Perkawinan (Studi Empiris Adat Dayak Ngajudi Kota Palangka Raya)
Authors: Nisa Nurulia Shalehatun 
Published: May 2023

Marriage agreements in Indonesia are regulated in the Civil Code (KUHPerdata), Compilation of Islamic Law (KHI), and Law Number 1 of 1974 concerning Marriage (Marriage Law) jo. Decision of the Constitutional Court Number 69/PUU-XIII/2015 so that the marriage agreement is legal and lawful. The marriage agreement in the Dayak Ngaju indigenous people is called a symbol. Perlambang is one of a series of traditional Dayak Ngaju marriage procedures. This paper aims to analyze the practice of marriage agreements that grow and live to become a culture of the Dayak Ngaju indigenous people in Palangka Raya City when viewed from the point of view of 'Urf. This writing is the result of research qualitative or empirical studies.The marriage agreement made to the Ngaju Dayak indigenous people has an important role, even though it is part of a series of traditional marriage rituals which in fact originates from the Hindu Kaharingan religion, but in its journey along with the introduction of Islam among the people, it has experienced various adaptations and adjustments to Islamic beliefs. . So that in practice, marriage agreements in the Dayak Ngaju customary community can still be carried out and benefited even by people who are Muslim.