bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐Warburg effect via generation of ROS and inhibition of PKM2/β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cells
Authors: Pak Ji‐Na , Lee Hyo‐Jung , Sim Deok Yong , Park Ji Eon , Ahn Chi‐Hoon , Park Su‐Yeon , Khil Jae‐Ho , Shim Bumsang , Kim Bonglee , Kim Sung‐Hoon 
Published: May 2023

AbstractTo elucidate the underlying antitumor mechanism of lambertianic acid (LA) derived from Pinus koraiensis, the role of cancer metabolism related molecules was investigated in the apoptotic effect of LA in DU145 and PC3 prostate cancer cells. MTT assay for cytotoxicity, RNA interference, cell cycle analysis for sub G1 population, nuclear and cytoplasmic extraction, lactate, Glucose and ATP assay by ELISA, Measurement of reactive oxygen species (ROS) generation, Western blotting, and immunoprecipitation assay were conducted in DU145 and PC3 prostate cancer cells. Herein LA exerted cytotoxicity, increased sub G1 population and attenuated the expression of pro‐Caspase3 and pro‐poly (ADP‐ribose) polymerase (pro‐PARP) in DU145 and PC3 cells. Also, LA reduced the expression of lactate dehydrogenase A (LDHA), glycolytic enzymes such as hexokinase 2 and pyruvate kinase M2 (PKM2) with reduced production of lactate in DU145 and PC3 cells. Notably, LA decreased phosphorylation of PKM2 on Tyr105 and inhibited the expression of p‐STAT3, cyclin D1, C‐Myc, β‐catenin, and p‐GSK3β with the decrease of nuclear translocation of p‐PKM2. Furthermore, LA disturbed the binding of p‐PKM2 and β‐catenin in DU145 cells, which was supported by Spearman coefficient (0.0463) of cBioportal database. Furthermore, LA generated ROS in DU145 and PC3 cells, while ROS scavenger NAC (N‐acetyl L‐cysteine) blocked the ability of LA to reduce p‐PKM2, PKM2, β‐catenin, LDHA, and pro‐caspase3 in DU145 cells. Taken together, these findings provide evidence that LA induces apoptosis via ROS generation and inhibition of PKM2/β‐catenin signaling in prostate cancer cells.
Research on unmanned electric shovel autonomous driving path tracking control based on improved pure tracking and fuzzy control
Authors: Wu Guohua , Wang Guoqiang , Bi Qiushi , Wang Yongpeng , Fang Yi , Guo Guangyong , Qu Wentao 
Published: May 2023

AbstractThis paper proposes a path tracking control method combining pure tracking algorithms and self‐adaptive fuzzy control for autonomous driving of an unmanned electric shovel. An improved pure tracking controller was designed based on the kinematic model of heavy crawler taking both the value of deviation and its variation as inputs with the crawler speed on each side as output. The proposed controller and MPC algorithm were simulated using MATLAB for comparison. The results show that the proposed controller has more anthropomorphic characteristics than the MPC method. To verify the actual control effect of the controller, experiments were carried out using a prototype electric shovel for different working conditions. The experimental results proved that the controller is able to meet the control requirements for unmanned electric shovel path tracking.
An Extended Variational Mode Decomposition Algorithm Developed Speech Emotion Recognition Performance
Authors: Hason Rudd David , Huo Huan , Xu Guandong 
Published: May 2023

AbstractEmotion recognition (ER) from speech signals is a robust approach since it cannot be imitated like facial expression or text based sentiment analysis. Valuable information underlying the emotions are significant for human-computer interactions enabling intelligent machines to interact with sensitivity in the real world. Previous ER studies through speech signal processing have focused exclusively on associations between different signal mode decomposition methods and hidden informative features. However, improper decomposition parameter selections lead to informative signal component losses due to mode duplicating and mixing. In contrast, the current study proposes VGG-optiVMD, an empowered variational mode decomposition algorithm, to distinguish meaningful speech features and automatically select the number of decomposed modes and optimum balancing parameter for the data fidelity constraint by assessing their effects on the VGG16 flattening output layer. Various feature vectors were employed to train the VGG16 network on different databases and assess VGG-optiVMD reproducibility and reliability. One, two, and three-dimensional feature vectors were constructed by concatenating Mel-frequency cepstral coefficients, Chromagram, Mel spectrograms, Tonnetz diagrams, and spectral centroids. Results confirmed a synergistic relationship between the fine-tuning of the signal sample rate and decomposition parameters with classification accuracy, achieving state-of-the-art 96.09% accuracy in predicting seven emotions on the Berlin EMO-DB database.
New Solutions to the Tetrahedron Equation Associated with Quantized Six-Vertex Models
Authors: Kuniba Atsuo , Matsuike Shuichiro , Yoneyama Akihito 
Published: May 2023

AbstractWe present a family of new solutions to the tetrahedron equation of the form $$RLLL=LLLR$$

R
L
L
L
=
L
L
L
R

, where L operator may be regarded as a quantized six-vertex model whose Boltzmann weights are specific representations of the q-oscillator or q-Weyl algebras. When the three L’s are associated with the q-oscillator algebra, R coincides with the known intertwiner of the quantized coordinate ring $$A_q(sl_3)$$

A
q

(
s

l
3

)

. On the other hand, L’s based on the q-Weyl algebra lead to new R’s whose elements are either factorized or expressed as a terminating q-hypergeometric type series.
An estimator for the recombination rate from a continuously observed diffusion of haplotype frequencies
Authors: Griffiths Robert C. , Jenkins Paul A. 
Published: May 2023

AbstractRecombination is a fundamental evolutionary force, but it is difficult to quantify because the effect of a recombination event on patterns of variation in a sample of genetic data can be hard to discern. Estimators for the recombination rate, which are usually based on the idea of integrating over the unobserved possible evolutionary histories of a sample, can therefore be noisy. Here we consider a related question: how would an estimator behave if the evolutionary history actually was observed? This would offer an upper bound on the performance of estimators used in practice. In this paper we derive an expression for the maximum likelihood estimator for the recombination rate based on a continuously observed, multi-locus, Wright–Fisher diffusion of haplotype frequencies, complementing existing work for an estimator of selection. We show that, contrary to selection, the estimator has unusual properties because the observed information matrix can explode in finite time whereupon the recombination parameter is learned without error. We also show that the recombination estimator is robust to the presence of selection in the sense that incorporating selection into the model leaves the estimator unchanged. We study the properties of the estimator by simulation and show that its distribution can be quite sensitive to the underlying mutation rates.
The distribution pattern of pelvic lymph nodal metastases in cervical cancer
Authors: Xie Shangdan , Zhao Jing , Wang Xintao , Hu Yan , Feng Guannan , Zhu Haiyan , Wang Chao 
Published: May 2023

Abstract
Purpose
Depiction of pelvic lymph node metastasis (LNM) sites among patients with cervical cancer facilitates accurate determination of the extent of dissection and radiotherapy regimens.

Methods
A retrospective study of 1182 cervical cancer patients who underwent radical hysterectomy and pelvic lymph node dissection between 2008 and 2018 was performed. The number of removed pelvic lymph nodes and metastasis status in different anatomical regions was analyzed. The prognostic difference of patients with lymph node involvement stratified by various factors was analyzed by Kaplan–Meier method.

Results
The median number of pelvic lymph nodes detected was 22, mainly from obturator (29.54%) and inguinal (21.14%) sites. Metastatic pelvic lymph nodes were found in 192 patients, with obturator accounting for the highest percentage (42.86%). The patients with lymph node involvement in single site had better prognosis that those in multiple sites. The overall- (P = 0.021) (OS) and progression-free (P < 0.001) survival (PFS) curves of patients with inguinal lymph node metastases were worse compared to those with obturator site. There was no difference in the OS and PFS among patients with 2 and more than 2 lymph nodes involvement.

Conclusion
An explicit map of LNM in patients with cervical cancer was presented in this study. Obturator lymph nodes tended to be involved. The prognosis of patients with inguinal lymph node involvement was poor in contrast to that with obturator LNM. In patients with inguinal lymph node metastases, clinical staging needs to be reconsidered and extended radiotherapy to the inguinal region needs to be strengthened.
Distribution, hosts and long-term decline in abundance of the Patagonian lamprey inferred from diet assessment of albatrosses
Authors: Phillips Richard A. , Waluda Claire M. , Miller Allison K. 
Published: May 2023

AbstractKnowledge of lampreys during their marine phase is limited, and for the southern hemisphere species was gleaned from their predators (albatrosses) in the 1970s. Taking advantage of new methodologies and long-term data on predator diet and distributions, we infer diverse aspects of lamprey distribution and ecology. DNA analyses indicated that albatrosses at South Georgia prey on Patagonian lamprey Geotria macrostoma, originating from Argentina. Their core pelagic distribution when free swimming appears to be the Antarctic Polar Frontal zone (APFZ), and not South Georgia waters as assumed previously. If so, the APFZ would be the first known hotspot in abundance of an anadromous lamprey in oceanic waters. We could not identify a teleost fish that would be a likely host. Instead, we infer that the lamprey may prey on baleen whales, based on comparison of stable isotope ratios in lamprey with candidate host species, timing of appearance in albatross diets coincident with whale migrations, and circumstantial evidence (unexplained scarring recorded during the whaling era). We suggest that the lamprey do not tolerate cold Antarctic waters, and detach from southerly-migrating whales at the thermal boundary of the APFZ, where they become accessible to albatrosses in surface waters. Given strong evidence that relative importance of prey in seabird diets reflects availability in foraging areas, the steep decrease in the annual consumption of lamprey by albatrosses at South Georgia from > 550 tonnes in 1975–1976 and 1986, to very low levels in most years since 2012, is likely to indicate a major population decrease. Despite our unconventional means of assessing the population trend, there is a compelling case for listing of Patagonian lamprey at least as Near threatened by the International Union for the Conservation of Nature, and an urgent need to better understand anthropogenic threats in Argentina.
Magnetic Field Modeling and Visualization of the Europa Clipper Spacecraft
Authors: Cochrane Corey J. , Murphy Neil , Raymond Carol A. , Biersteker John B. , Dang Katherine , Jia Xianzhe , Korth Haje , Narvaez Pablo , Ream Jodie B. , Weiss Benjamin P. 
Published: May 2023

AbstractThe goal of NASA’s Europa Clipper Mission is to investigate the habitability of the subsurface ocean within the Jovian moon Europa using a suite of ten investigations. The Europa Clipper Magnetometer (ECM) and Plasma Instrument for Magnetic Sounding (PIMS) investigations will be used in unison to characterize the thickness and electrical conductivity of Europa’s subsurface ocean and the thickness of the ice shell by sensing the induced magnetic field, driven by the strong time-varying magnetic field of the Jovian environment. However, these measurements will be obscured by the magnetic field originating from the Europa Clipper spacecraft. In this work, a magnetic field model of the Europa Clipper spacecraft is presented, characterized with over 260 individual magnetic sources comprising various ferromagnetic and soft-magnetic materials, compensation magnets, solenoids, and dynamic electrical currents flowing within the spacecraft. This model is used to evaluate the magnetic field at arbitrary points around the spacecraft, notably at the locations of the three fluxgate magnetometer sensors and four Faraday cups which make up ECM and PIMS, respectively. The model is also used to evaluate the magnetic field uncertainty at these locations via a Monte Carlo approach. Furthermore, both linear and non-linear gradiometry fitting methods are presented to demonstrate the ability to reliably disentangle the spacecraft field from the ambient using an array of three fluxgate magnetometer sensors mounted along an 8.5-meter (m) long boom. The method is also shown to be useful for optimizing the locations of the magnetometer sensors along the boom. Finally, we illustrate how the model can be used to visualize the magnetic field lines of the spacecraft, thus providing very insightful information for each investigation.
A comparison of zero- and minimal-intelligence agendas in majority-rule voting models
Authors: Brewer Paul , Juybari Jeremy , Moberly Raymond 
Published: May 2023

AbstractEmergent behavior in repeated collective decisions of minimally intelligent agents—who at each step in time invoke majority rule to choose between a status quo and a random challenge—can manifest through the long-term stationary probability distributions of a Markov chain. We use this known technique to compare two kinds of voting agendas: a zero-intelligence agenda that chooses the challenger uniformly at random and a minimally intelligent agenda that chooses the challenger from the union of the status quo and the set of winning challengers. We use Google Co-Lab’s GPU accelerated computing environment to compute stationary distributions for some simple examples from spatial-voting and budget-allocation scenarios. We find that the voting model using the zero-intelligence agenda converges more slowly, but in some cases to better outcomes.
Developing Organizational Diversity Statements Through Dialogical Clinical Ethics Support: The Role of the Clinical Ethicist
Authors: Kröger Charlotte , Molewijk Albert C. , Metselaar Suzanne 
Published: May 2023

AbstractIn pluralist societies, stakeholders in healthcare may have different experiences of and moral perspectives on health, well-being, and good care. Increasing cultural, religious, sexual, and gender diversity among both patients and healthcare professionals requires healthcare organizations to address these differences. Addressing diversity, however, comes with inherent moral challenges; for example, regarding how to deal with healthcare disparities between minoritized and majoritized patients or how to accommodate different healthcare needs and values. Diversity statements are an important strategy for healthcare organizations to define their normative ideas with respect to diversity and to establish a point of departure for concrete diversity approaches. We argue that healthcare organizations ought to develop diversity statements in a participatory and inclusive way in order to promote social justice. Furthermore, we maintain that clinical ethicists can support healthcare organizations in developing diversity statements in a more participatory way by fostering reflective dialogues through clinical ethics support. We will use a case example from our own practice to explore what such a developmental process may look like. We will critically reflect on the procedural strengths and challenges as well as on the role of the clinical ethicist in this example.
Masturbation Among Malaysian Young Adults: Associated Sexual and Psychological Well-Being Outcomes
Authors: Phuah Li Ann , Teng Jaclyn Hui Jie , Goh Pei Hwa 
Published: May 2023

AbstractDespite being a common sexual practice, not much is known about masturbation within the Malaysian context. The current study examined the masturbation practices of a convenience sample of Malaysian young adults, and how one’s reported experience of masturbating and frequency of masturbation is associated with sexual and psychological well-being. Satisfaction with sex life, satisfaction with life, depression, anxiety, and stress were measured as outcome variables. Responses from 621 participants (M = 22.1 years, SD = 2.4 years) that were collected through an online questionnaire were analyzed. Results revealed that most participants (77.7%) had masturbated at least once in their life. Sexual satisfaction and psychological well-being did not differ between those who reported masturbating before and those who did not. Among those with masturbation experience, higher frequency of masturbation was associated with less sexual satisfaction and more symptoms of anxiety and stress. Masturbation frequency was not associated with life satisfaction or reports of depressive symptoms. Gender, frequency of partnered sex, availability of a sexual partner, and religiosity did not moderate the relationships between masturbation frequency with sexual satisfaction and psychological well-being. Although the limitations of the current study impede generalizability, masturbation was found to be a common behavior among the current sample. Causal inferences cannot be drawn from the significant associations found in the current study, as the findings indicate such relationships may be bidirectional.
A broadband integrated microwave photonic mixer based on balanced photodetection
Authors: Xu Zhenzhu , Mei Li , Chong Yuhua , Gao Xudong , Han Shoubao , Yang Chengkun , Li Lin 
Published: May 2023

AbstractAn integrated microwave photonic mixer based on silicon photonic platforms is proposed, which consist of a dual-drive Mach–Zehnder modulator and a balanced photodetector. The modulated optical signals from microwave photonic links can be directly demodulated and down-converted to intermediate frequency (IF) signals by the photonic mixer. The converted signal is obtained by conducting off-chip subtraction of the outputs from the balanced photodetector, and subsequent filtering of the high frequency items by an electrical low-pass filter. Benefiting from balanced detection, the conversion gain of the IF signal is improved by 6 dB, and radio frequency leakage and common-mode noise are suppressed significantly. System-level simulations show that the frequency mixing system has a spurious-free dynamic range of 89 dB·Hz2/3, even with deteriorated linearity caused by the two cascaded modulators. The spur suppression ratio of the photonic mixer remains higher than 40 dB when the IF varies from 0.5 to 4 GHz. The electrical-electrical 3 dB bandwidth of frequency conversion is 11 GHz. The integrated frequency mixing approach is quite simple, requiring no extra optical filters or electrical 90° hybrid coupler, which makes the system more stable and with broader bandwidth so that it can meet the potential demand in practical applications.
Graphical Abstract
Horizontal and Straight Triangulation on Heisenberg Groups
Authors: Canarecci Giovanni 
Published: May 2023

AbstractThis paper aims to show that there exists a triangulation of the Heisenberg group $$\mathbb {H}^n$$

H

n

into singular simplexes with regularity properties on both the low-dimensional and high-dimensional layers. For low dimensions, we request our simplexes to be horizontal while, for high dimensions, we define a notion of straight simplexes using exponential and logarithmic maps, and we require our simplexes to have high-dimensional straight layers. A triangulation with such simplexes is first constructed on a general polyhedral structure and then extended to the whole Heisenberg group. In this paper, we also provide some explicit examples of grid and triangulations.
Development of a Standardised System to Classify Injury-Inciting Circumstances in Football: the Football Injury Inciting Circumstances Classification System (FIICCS)
Authors: Aiello Francesco , McCall Alan , Brown Susan J. , Serner Andreas , Fortington Lauren V. , Huurman Suzanne Afra Elisabeth , Lewin Colin , Nagao Masashi , O’Brien James , Panossian Anastasia , Pruna Ricard , Ramos Guilherme Passos , Whalan Matthew , Impellizzeri Franco M. 
Published: May 2023

AbstractBackgroundA comprehensive examination of the sport-specific activities and circumstances being performed at the time of injury is important to hypothesise mechanisms, develop prevention strategies and inform future investigations. Results reported in the literature are inconsistent because inciting activities are reported using different classifications. Hence the aim was to develop a standardised system for the reporting of inciting circumstances.MethodsThe system was developed using a modified Nominal Group Technique. The initial panel included 12 sports practitioners and researchers from four continents with respectively ≥ 5 years of experience working in professional football and/or conducting injury research. The process consisted of six phases: idea generation, two surveys, one online meeting and two confirmations. For answers to the closed questions, consensus was deemed achieved if ≥ 70% of respondents agreed. Open-ended answers were qualitatively analysed and then introduced in subsequent phases.ResultsTen panellists completed the study. The risk of attrition bias was low. The developed system includes a comprehensive range of inciting circumstances across five domains: contact type, ball situation, physical activity, session details, contextual information. The system also distinguishes between a core set (essential reporting) and an optional set. The panel deemed all the domains to be important and easy to use both in football and in research environments.ConclusionA system to classify inciting circumstances in football was developed. Given the extent of reporting inconsistency of inciting circumstances in the available literature, this can be used while further studies evaluate its reliability.
Preventing varicella zoster infection in immunocompromised adults with varicella zoster–specific immunoglobulins
Authors: Gelman Daniel , Zektser Miri , Nesher Lior 
Published: May 2023

Abstract

Background:
Varicella zoster virus (VZV) exposure seriously threatens immunocompromised hosts. Postexposure prophylaxis (PEP) using immune globulins is considered the standard of care; however, the available literature is mainly based on its use in pediatric patients. Here, we describe a widespread VZV exposure among immunocompromised adults treated with VZV-specific immunoglobulins (VZVSIG), and we discuss management and outcomes.

Methods:
We conducted a retrospective study to describe the exposure of immunocompromised patients to a single healthcare worker with primary VZV in 2019. Patients were grouped by their overall risk for infection, and those at risk received a single intramuscular dose of 625 IU of VZVSIG and were followed for 1 year.

Results:
In total, 83 patients received PEP at <96 hours of exposure: 14 were hospitalized, 68 were outpatients, and 1 was an immunocompromised staff member. The median age was 69 years (range, 21–92), and 49.4% were male. In addition, 30% of the patients were deemed high risk, 42% were intermediate risk, and 28% were considered low risk, although they were given PEP. Varicella infection was not diagnosed in any patient in the first weeks of follow-up. However, during the year of follow-up, 4 patients developed symptoms suspicious of VZV, all >3 months after exposure, thus were probably unrelated to the event. Adverse events related to VZVSIG (pyrexia) were reported in 2 patients (2.4%).

Conclusions:
Our findings demonstrate the utility of VZVSIG as PEP in one of the largest cohorts of immunocompromised adults to date. No early varicella infection was found following exposure, supporting the current recommendations of the VZVSIG administration.