bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Photovoice foster the development of social support?
Authors: Agner Joy , Nakamura Lisa , Botero Adriana , Cha Tiffany , Kaukau Tyra Mahealani 
Published: January 2023

AbstractPhotovoice is a participatory, photo‐based research method that differs from conventional (non‐participatory) research in that the process is meant to be empowering and beneficial. However, empirical research on the Photovoice process remains very limited. Based on feedback from participants who reported Photovoice helped them develop closer relationships, we examine whether engaging in Photovoice fosters social support. Transcripts from a Photovoice study on wellness in mental health Clubhouses (voluntary, community mental health centers) were retrospectively analyzed for instrumental support, appraisal, informational support, and emotional support. Appraisal was the most common form of social support identified, and was primarily expressed through peer praise for photos and insights. Informational support included advice on managing symptoms, promoting wellness, and navigating challenges. Instrumental support was fostered by learning the tangible skill of digital photography and by supporting fellow members with physical or visual limitations to participate in the process. Emotional support was cultivated through encouragement, identification of shared experiences, and connection through humor. In sum, the findings suggest that Photovoice has the potential to foster social support, which may support relational empowerment.
Associations of vitamin D receptor encoding gene variants with premenopausal breast cancer risk
Authors: Iqbal Mehir un Nisa , Maqbool Syed Amir , Khan Taseer Ahmed 
Published: January 2023

AbstractObjectiveThis study evaluates whether vitamin D receptor (VDR) gene variations are associated with premenopausal breast cancer in Pakistani cohorts.MethodsGenomic DNA was isolated from 228 breast cancer patients and 500 non‐cancer controls. Six polymorphic variants (rs11568820, rs4516035, rs2228570, rs1544410, rs7975232, rs731236) of the VDR gene were genotyped using PCR‐RFLP analysis. All statistical analysis was carried out on IBM‐SPSS 23 at p‐value <.05. Chi‐square test and odds ratios (ORs) along with 95% confidence interval (CIs) were applied to evaluate the relationship between VDR gene polymorphisms and breast cancer.ResultsResults showed that the A/A genotype of EcoRV (OR = 2.125, 95% CI = 1.024 to 4.412) and the A/a genotype of Apa1 (OR = 6.094, 95%CI = 4.111 to 9.033) gene polymorphism had an increased risk of premenopausal breast cancer. No associations of the Bsm1 and Taq1 polymorphisms were observed in premenopausal women. Moreover, the Cdx2 GG (OR = 0.34, 95%CI = 0.192–0.602) genotype had a significant protective effect on breast cancer. However, strong LD was existed between Bsm1/Taq1 (D′ = 0.757, CI = 0.67–0.82) and Apa1/Taq1 (D′ = 0.695, CI = 0.6–0.77). Haplotype analysis showed no association between premenopausal breast cancer and VDR haplotypes.ConclusionThese analyses indicates that the VDR EcoRV A/A and Apa1 A/a genotypes may be risk factors for breast cancer development among premenopausal women.
Enantioselective C−H Borylation for the Synthesis of Axially ChiralN‐Aryl Phthalimides
Authors: Zhao Hongliang , Chen Lili , Xia Chungu , Xu Senmiao 
Published: January 2023

AbstractAxially chiral compounds with a rotation restricted N−C bond are of great importance in synthetic chemistry, pharmaceuticals, and material sciences. The search for efficient and selective routes for the synthesis of these frameworks is of great interest and importance. We herein disclose an iridium‐catalyzed asymmetric C−H borylation protocol for the enantioselective synthesis of chiralN‐aryl phthalimides. The current method features good compatibility of functional groups, broad substrate scope, and high enantioselectivities. We also demonstrate the synthetic utility on a gram‐scale C−H borylation for diverse C−B bond transformations, including the preparation of a chiral catalyst for asymmetric catalysis.
Turning on the Antimicrobial Activity of Gold Nanoclusters Against Multidrug‐Resistant Bacteria**
Authors: Ndugire William , Truong Dang , Raviranga N. G. Hasitha , Lao Jingzhe , Ramström Olof , Yan Mingdi 
Published: January 2023

AbstractIn this work, we show that the addition of thiourea (TU) initiated broad‐spectrum antimicrobial activity of otherwise inactive D‐maltose‐capped gold nanoclusters (AuNC‐Mal). For example, AuNC‐Mal/TU was effective against multidrug‐resistant Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 1 μg mL−1 (2.5 μM [Au]) while having 30–60 times lower in vitro cytotoxicity against mammalian cells. The reaction of AuNC‐Mal and TU generated the antimicrobial species of [Au(TU)2]+ and smaller AuNCs. TU increased the accumulation of Au in bacteria and helped maintain the oxidation state as AuI (vs. AuIII). The modes of action included the inhibition of thioredoxin reductase, interference with the CuI regulation and depletion of ATP. Moreover, the antimicrobial activity did not change in the presence of colistin or carbonyl cyanide 3‐chlorophenylhydrazone, suggesting that AuNC‐Mal/TU was indifferent to the outer membrane barrier and to bacterial efflux pumps.
Boosting Hydrogen Production via Selective Two‐electron Mild Electrochemical Oxidation of Tetrahydroisoquinolines Completely to Dihydroisoquinolines
Authors: Zhou Zhaoyu , Pan Xun , Sun Lingzhi , Xie Yanan , Zheng Jingui , Li Lina , Zhao Guohua 
Published: January 2023

AbstractDifferent from the previous study that biomass derivatives replace water oxidation for enhancing hydrogen production, we found that mild oxidation was more conductive to cathodic hydrogen production. In this study, maximum Faradaic efficiency (>99 %) and lower energy consumption for hydrogen production was achieved by precisely controlling the two‐electron mild electrochemical oxidation of tetrahydroisoquinolines (THIQs) to dihydroisoquinolines (DHIQs) in place of the four‐electron deep oxidation to isoquinolines (IQs). Moreover, the high value‐added DHIQs were prepared from THIQs with high selectivity (>99 %) at the low potential of 1.36 V. Operando electrochemical Raman and density functional theory proved that the high selectivity was attributed to the regulable active species of NiOOH induced by the interaction of Co and Fe for preferentially breaking C−H bond rather than N−H of THIQs. This novel method provides important insight into efficient biomass‐assisted hydrogen production.
Festkörper‐Analyse, Speicherung und Trennung von Pyrophorem PH3 und P2H4 mit α‐Mg Formiat
Authors: Widera Anna , Thöny Debora , Aebli Marcel , Oppenheim Julius Jacob , L.Andrews Justin , Eiler Frederik , Wörle Michael , Schönberg Hartmut , Weferling Norbert , Dincǎ Mircea , Grützmacher Hansjörg 
Published: January 2023

AbstractPhosphan, PH3 – ein hochpyrophores und toxisches Gas – ist gewöhnlich mit H2 und P2H4 kontaminiert, was seine Handhabung gefährlich macht. Die kostengünstige metallorganische Gerüstverbindung (MOF) aus Magnesiumformiat, α‐[Mg(O2CH)2], kann bis zu 10 wt % PH3 adsorbieren. Das mit PH3 beladene MOF, PH3@α‐[Mg(O2CH)2], ist ein nicht pyrophores, rückgewinnbares Material, das eine kurze Handhabung von PH3 an Luft ermöglicht und die Gefahren bei der Handhabung und dem Transport von Phosphan reduziert. α‐[Mg(O2CH)2] spielt außerdem eine wichtige Rolle bei der PH3‐Reinigung von H2 und P2H4: bei 25 °C diffundiert H2 direkt durch die MOF‐Kanäle ohne Adsorption, PH3 wird adsorbiert und desorbiert nur langsam unter einem Strom von Inertgas (Desorptionszeit≈6 h). Diphosphan, P2H4, wird von dem MOF‐Gerüst stark adsorbiert und bleibt für länger als 4 Monate eingeschlossen. P2H4@α‐[Mg(O2CH)2] selbst ist nicht pyrophor, sondern luft‐ und lichtstabil bei Raumtemperatur.
Selective 3,3‐Rearrangement of Azobenzenes upon Complexation by a Frustrated Lewis Pair
Authors: Wickemeyer Lucas , Fernández Israel , Neumann Beate , Stammler Hans‐Georg , Mitzel Norbert W. 
Published: January 2023

AbstractThe reaction of the oxygen‐bridged frustrated Lewis pairs (FLPs) tBu2P−O−Si(C2F5)3 (1) and tBu2P−O−AlBis2 (2) with azobenzene, promoted by UV irradiation, led to a selective complexation of the cis‐isomer. The addition product of 2 is stable, while the adduct of 1 isomerizes in solution in an ortho‐benzidine‐like [3,3]‐rearrangement by cleavage of the N−N bond, saturation of the nitrogen atoms with hydrogen atoms and formation of a new bond between two phenyl ortho‐carbon atoms. Similar rearrangements take place with different para‐substituted azobenzenes (R=Me, OMe, Cl) and di(2‐naphthyl)diazene, while ortho‐methylated azo compounds do not form adducts with 1. All adducts were characterized by multinuclear NMR spectroscopy and elemental analyses and the mechanism of the rearrangement was explored by quantum‐chemical calculations.
Embedding knowledge graph of patent metadata to measure knowledge proximity
Authors: Li Guangtong , Siddharth L. , Luo Jianxi 
Published: January 2023

AbstractKnowledge proximity refers to the strength of association between any two entities in a structural form that embodies certain aspects of a knowledge base. In this work, we operationalize knowledge proximity within the context of the US Patent Database (knowledge base) using a knowledge graph (structural form) named “PatNet” built using patent metadata, including citations, inventors, assignees, and domain classifications. We train various graph embedding models using PatNet to obtain the embeddings of entities and relations. The cosine similarity between the corresponding (or transformed) embeddings of entities denotes the knowledge proximity between these. We compare the embedding models in terms of their performances in predicting target entities and explaining domain expansion profiles of inventors and assignees. We then apply the embeddings of the best‐preferred model to associate homogeneous (e.g., patent–patent) and heterogeneous (e.g., inventor–assignee) pairs of entities.
Finite‐time command filter‐based adaptive tracking control for nonstrict feedback nonlinear systems with full‐state restrictions and unmodeled dynamics
Authors: Zhu Xinfeng , Huang Jun , Ding Wenwu , Zhang Tianping 
Published: January 2023

AbstractThe finite‐time command filter tracking control for a class of nonstrictly feedback nonlinear systems with unmodeled dynamics and full‐state constraints is investigated in this paper. The hyperbolic tangent function is used as a nonlinear mapping technique to solve the obstacle of the full‐state constraints. A new adaptive finite time control method is proposed through command filtering reverse engineering, and the shortcomings of the dynamic surface control (DSC) method are overcome by the error compensation mechanism. Dynamic signal is designed to handle dynamical uncertain terms. Normalization signal is designed to handle input unmodeled dynamics. Unknown nonlinear functions are approximated by radial basis function neural networks. Based on the Lyapunov stability theory, it is proved that all signals in the closed‐loop system are semi‐globally consistent and finally bounded and the output tracking error converges in finite time. Two numerical examples are utilized to verify the effectiveness of the proposed control approach.
Adaptive fault‐tolerant control of switched nonlinear systems based on tuning function method
Authors: Li Ya‐Xin , Wu Li‐Bing , Hu Yu‐Han , Zhao Nan‐Nan , Nie Jin 
Published: January 2023

AbstractThis paper solves the problem of adaptive fault‐tolerant control of uncertain switched nonlinear systems with unknown parameters and actuator failures. Based on the multi‐Lyapunov function method, a novel adaptive switched controller with tuning function is designed using the backstepping procedure. Meanwhile, a switched fault‐tolerant adaptation mechanism is also given to compensate the fault efficiency. Furthermore, it is certificated that all the signals of the closed‐loop system are uniformly bounded and the tracking error restrain to a small neighbor. Finally, the simulation results verify the feasibility of the proposed method.
Prevalence and treatment of mental, behavioral, and developmental disorders in children with co‐occurring autism spectrum disorder and attention‐deficit/hyperactivity disorder: A population‐based study
Authors: Casseus Myriam , Kim Wun Jung , Horton Daniel B. 
Published: January 2023

AbstractThere is a lack of nationally representative studies examining the co‐occurrence of autism spectrum disorder (ASD) and attention‐deficit/hyperactivity disorder (ADHD) in children. This study examines comorbid mental, behavioral, and developmental disorders (MBDDs) and associated treatment modalities for children with co‐occurring ASD and ADHD. Cross‐sectional analyses were conducted using data from the pooled 2016–2018 National Survey of Children's Health (sample n = 102,341). Nationally representative prevalences were estimated for sociodemographic variables, comorbidities, psychotropic medication, and behavioral treatment. We assessed multivariable associations between co‐occurring ASD + ADHD and MBDDs, use of psychotropic medication, and receipt of behavioral treatment after adjustment for sociodemographic confounders. Compared to children with ASD without co‐occurring ADHD, children with ASD + ADHD had higher prevalence of most MBDDs, including anxiety (AOR 4.03 [95% CI 2.77, 4.87]), depression (AOR 3.08 [95% CI 1.77, 5.36]), behavior or conduct problems (AOR 4.06 [95% CI 2.72, 6.06]), and other mental health conditions. Similarly, compared to children with ADHD without ASD, children with ASD + ADHD had higher odds of anxiety (AOR 3.49 [95% CI 2.65, 4.61]), depression (AOR 1.67 [95% CI 1.21, 2.29]), behavior or conduct problems (AOR 2.31 [95% CI 1.68, 3.17]), and other mental health conditions. Children with ASD + ADHD were significantly more likely to take psychotropic medication than children with ASD without ADHD. Among children with ASD + ADHD, males had higher odds of receiving behavioral treatment, whereas older children and adolescents were more likely to take psychotropic medication. A multidisciplinary approach is necessary to support the complex needs of these children.
Modulation of Chiroptical and Photophysical Properties in Helicenic Rhenium(I) Systems: The Use of an N‐(Aza[6]helicenyl)‐NHC Ligand
Authors: Gauthier Etienne S. , Abella Laura , Caytan Elsa , Roisnel Thierry , Vanthuyne Nicolas , Favereau Ludovic , Srebro‐Hooper Monika , Williams J. A. Gareth , Autschbach Jochen , Crassous Jeanne 
Published: January 2023

AbstractThe photophysical and chiroptical properties of a novel, chiral helicene‐NHC−Re(I) complex bearing an N‐(aza[6]helicenyl)‐benzimidazolylidene ligand are described, showing its ability to emit yellow circularly polarized luminescence. A comparative analysis of this new system with other helicene‐Re(I) complexes reported to date illustrates the impact of structural modifications on the emissive and absorptive properties.
Pharmacokinetics and Comparative Bioavailability of Test or Reference Capecitabine and Discrepant Pharmacokinetics Among Various Tumors in Chinese Solid Cancer Patients
Authors: Li Xiaoyu , Cui Dongyang , Xiong Jianping , Dang Qi , Wen Qing , Yan Min , Li Hongxia , Jiang Xiaodong , Lin Cuihong , Xie Xianhe , Wang Teng , Xiang Lisha , Wang Yongsheng , Zheng Li 
Published: January 2023

AbstractThe main objective of this study was to compare the pharmacokinetic (PK) bioequivalence of two capecitabine tablets and explore the different PK profiles of various tumors in Chinese patients with cancer. All 76 patients with a confirmed cancer diagnosis were included in this study. A single dose of 2000 mg of test or reference capecitabine (Xeloda, Hoffmann–La Roche) was orally administered postprandially. After 24 hours of washout, the patients were administered the test or the reference capecitabine alternately. PK samples were taken at the time of predose up to 6 hours postdose. Bioequivalence evaluation was performed using the geometric mean ratios of peak concentration in plasma (Cmax), area under the concentration‐time curve from time 0 to 6 h (AUC0‐t), and area under the concentration‐time curve from time 0 to infinity (AUC0‐∞) for capecitabine and 5‐fluorouracil (5‐FU). In this study, 90% confidence intervals of test/reference mean ratios of Cmax, AUC0‐t, AUC0‐∞ of capecitabine and 5‐FU were in the range of 80%–125%. Both the test and reference capecitabine regimens were well tolerated in this study. Furthermore, we found that patients with esophageal‐gastrointestinal cancers had higher exposure to capecitabine and a shorter time to Cmax (Tmax) than those with breast cancer. In conclusion, a single oral dose of 2000 mg of test capecitabine tablets after postprandial administration was bioequivalent to the reference drug.
Pharmacokinetic and Bioequivalence Studies of 2 Metformin Glibenclamide Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions
Authors: Huang Xiaolun , Huang Jiao , Li Xinjing , Chen Lin 
Published: January 2023

AbstractThe rational combination of oral antidiabetic agents is more likely to provide better glycemic control than monotherapy. Metformin glibenclamide tablets can be used as second‐line therapy for patients with type 2 diabetes mellitus who cannot successfully control their blood glucose levels by diet and exercise plus metformin or sulfonylureas. The aim of this study was to evaluate the bioequivalence and safety of metformin hydrochloride and glibenclamide tablets (500 mg/5 mg) prepared by 2 different vendors in healthy Chinese subjects under fasting and fed conditions. This is an open‐label, single‐center, randomized, 2‐formulation, 2‐period crossover study. After screening, 40 subjects were enrolled in the fasting trial, while 40 subjects were enrolled in the fed trial. Qualified subjects were randomly assigned to receive a monotherapy dose of 500 mg/5 mg of the test or reference formulation, and after a 1‐week washout period, they took the alternative formulation. Blood samples were collected from 24 blood collection sites per cycle for pharmacokinetic analysis until 36 hours after oral administration. In total, 78 subjects completed the study. Under fasting and fed conditions, the geometric mean ratios of maximum plasma concentration, area under the plasma concentration–time curve (AUC) from time 0 to time of last quantifiable drug level , and AUC from time 0 to infinity between the 2 products, as well as the corresponding 90%CIs, were all within the range of 80%–125%. It was found that exposure (AUC from time 0 to infinity) to metformin is decreased by about 25% in the fed state compared to fasting, whereas glibenclamide exposure is increased by about 30% in the fed state. No severe adverse events were observed in the study.
Changes in habitat suitability for wintering dabbling ducks during dry conditions in the Central Valley of California
Authors: Conlisk Erin E. , Byrd Kristin B. , Matchett Elliott , Lorenz Austen A. , Casazza Michael , Golet Gregory H. , Reynolds Mark D. , Sesser Kristin A. , Reiter Matthew E. 
Published: January 2023

AbstractIn arid and Mediterranean regions, landscape‐scale wetland conservation requires understanding how wildlife responds to dynamic freshwater availability and conservation actions to enhance wetland habitat. Taking advantage of Landsat satellite data and structured and community science bird survey data, we built species distribution models to describe how three duck species, the Northern Pintail (Anas acuta), Green‐winged Teal (Anas crecca), and Northern Shoveler (Anas clypeata), respond to freshwater supply and food resources on different flooded land cover types in the Central Valley of California. Specifically, our models compared duck habitat suitability between the wettest and driest conditions in each month from September through April. Using abundance‐weighted boosted regression trees, we created three sets of species occurrence models based on different covariates: (1) near real‐time (hereafter “real‐time”) covariates in which duck observations were matched to the water availability within the 16‐day window of a Landsat observation, (2) a combination of real‐time covariates and waterfowl food resource covariates describing annual corn and rice biomass and managed wetland moist soil seed yield estimates derived from Landsat data, and (3) long‐term average covariates—the most common approach to species distribution modeling—in which long‐term average surface water availability was used. We modeled the monthly occurrence of three duck species as a function of surface water availability, land cover type, road density, temperature, and bird data source. We found that dry conditions result in reduced habitat suitability, with the biggest reductions in November through January and in agricultural fields; in contrast, suitability of flooded wetland habitat was relatively robust to surface water availability. When models of habitat suitability based on long‐term average climate conditions were compared to models based on real‐time conditions, the highest long‐term suitability values occurred in areas where suitability was high regardless of whether it was a wet or a dry year. While all models performed well, the inclusion of crop and wetland plant yield covariates resulted in slightly higher model performance. Overall, species distribution models created using data on the environmental conditions present at the time of bird observations can aid conservation efforts under extreme conditions over large spatial scales.
Effect of allogeneic adipose tissue‐derived mesenchymal stromal cell treatment in chronic ischaemic heart failure with reduced ejection fraction – the SCIENCE trial
Authors: Qayyum Abbas Ali , van Klarenbosch Bas , Frljak Sabina , Cerar Andraz , Poglajen Gregor , Traxler‐Weidenauer Denise , Nadrowski Pawel , Paitazoglou Christina , Vrtovec Bojan , Bergmann Martin W. , Chamuleau Steven A. J. , Wojakowski Wojtek , Gyöngyösi Mariann , Kraaijeveld Adriaan , Hansen Kristian Schultz , Vrangbæk Karsten , Jørgensen Erik , Helqvist Steffen , Joshi Francis Richard , Johansen Ellen Mønsted , Follin Bjarke , Juhl Morten , Højgaard Lisbeth Drozd , Mathiasen Anders Bruun , Ekblond Annette , Haack‐Sørensen Mandana , Kastrup Jens ,   the SCIENCE Investigators
Published: January 2023

AbstractAimsThe aim of the SCIENCE trial was to investigate whether a single treatment with direct intramyocardial injections of adipose tissue‐derived mesenchymal stromal cells (CSCC_ASCs) was safe and improved cardiac function in patients with chronic ischaemic heart failure with reduced ejection fraction (HFrEF).Methods and resultsThe study was a European multicentre, double‐blind, placebo‐controlled phase II trial using allogeneic CSCC_ASCs from healthy donors or placebo (2:1 randomization). Main inclusion criteria were New York Heart Association (NYHA) class II–III, left ventricular ejection fraction (LVEF) <45%, and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels >300 pg/ml. CSCC_ASCs or placebo (isotonic saline) were injected directly into viable myocardium. The primary endpoint was change in left ventricular end‐systolic volume (LVESV) at 6‐month follow‐up measured by echocardiography. A total of 133 symptomatic HFrEF patients were included. The treatment was safe without any drug‐related severe adverse events or difference in cardiac‐related adverse events during a 3‐year follow‐up period. There were no significant differences between groups during follow‐up in LVESV (0.3 ± 5.0 ml, p = 0.945), nor in secondary endpoints of left ventricular end‐diastolic volume (−2.0 ± 6.0 ml, p = 0.736) and LVEF (−1.6 ± 1.0%, p = 0.119). The NYHA class improved slightly within the first year in both groups without any difference between groups. There were no changes in 6‐min walk test, NT‐proBNP, C‐reactive protein or quality of life the first year in any groups.ConclusionThe SCIENCE trial demonstrated safety of intramyocardial allogeneic CSCC_ASC therapy in patients with chronic HFrEF. However, it was not possible to improve the pre‐defined endpoints and induce restoration of cardiac function or clinical symptoms.