bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Analysis of Different Environmental Disinfection Methods on Reducing Contamination of Surfaces by the Omicron BA.2.2 Variant of SARS-CoV-2 and the Characteristics of Fomite Contamination in the Fever Clinic in the Out-Broken of Shanghai
Authors: Yang Lei , Dong Wenfang , Shen Xiaoyu , Han Feng , Liu Chenxi , Wang Yirou , Xu Xuemei , Wu Yufen , Zhou Sha , Cao Qing 
Published: April 2023

AbstractThis study aimed to investigate the effect of different environmental disinfection methods on reducing contaminated surfaces (CSs) by the Omicron BA.2.2 variant of SARS-CoV-2 in the fever clinic between March 20 and May 30, 2022, and to analyze the influences and related factors of CSs. This study includes survey data from 389 positive patients (SPPs) and 204 CSs in the fever clinic, including the CS type, disinfection method, length of time spent in the clinic, cycle threshold (CT) value, name, age, weight, mask type, mask-wearing compliance, hand-mouth touch frequency and sex. Associations between study variables and specified outcomes were explored using univariate regression analyses. Mask-wearing compliance had a significant negative correlation with CSs (r = − 0.446, P = 0.037). Among the 389 SPPs, 22 SPPs (CRP, 5.66%) caused CSs in the separate isolation room. A total of 219 SPPs (56.30%) were male. The mean age of SPPs was 4.34 ± 3.92 years old, and the mean CT value was 12.44 ± 5.11. In total, 9952 samples with exposure history were taken, including 204 (2.05%) CSs. Among the CSs, the positive rate of flat surfaces was the highest in public areas (2.52%) and separate isolation rooms (4.75%). Disinfection methods of ultraviolet radiation + chemical irradiation significantly reduced the CSs in both the public area (0% vs. 4.56%) and the separate isolation room (0.76% vs. 2.64%) compared with the chemical method alone (P < 0.05). Compared with ordinary SPPs, CRPs were older (6.04 year vs. 4.23 year), and the male proportion was higher (72.73% vs. 55.31%). In particular, it was found that SPPs contaminated their surroundings and therefore imposed risks on other people. Environmental disinfection with ultraviolet radiation + chemical treatment should be emphasized. The findings may be useful to guide infection control practices for the Omicron BA.2.2 variant of SARS-CoV-2.
Numerical modeling of seismic wave propagation in loosely deposited partially saturated sands: an application to a mine dump monitoring case
Authors: Deng Tengfei , Hellwig Olaf , Hlousek Felix , Kern Dominik , Buske Stefan , Nagel Thomas 
Published: April 2023

AbstractExtensive mine dumps consisting of loosely deposited sands have been created as a result of open-pit lignite mining, with a risk of soil liquefaction under high water saturation and a corresponding initiating event. Soil compaction is one of the feasible methods for reducing the probability of liquefaction. For the monitoring of liquefaction events and the evaluation of compaction work, seismic survey methods with sensitivity to changes in soil saturation and structure may thus complement other methods. Compared to exploration methods for deep systems, the shallow subsurface presents some unique challenges. To this end, an open-source, customizable code based on Biot’s theory was developed in the FEniCS library, which takes into account partial saturation and porosity dependence of stiffness, permeability, and other quantities. Following code verification, a comprehensive investigation of parameter studies is conducted, from which the effects of different factors on wave propagation characteristics were obtained. The numerical model was applied to simulate the expected changes in seismic response following soil compaction. Furthermore, the position of the high saturation area could be detected from the reflection and refraction P waves. The goal of this work is to provide an analysis framework for the assessment of compaction works and monitoring liquefiable soils in mine dumps under conditions of variable saturation due to rising groundwater tables.
Combining noisy well data and expert knowledge in a Bayesian calibration of a flow model under uncertainties: an application to solute transport in the Ticino basin
Authors: Baker Emily A. , Manenti Sauro , Reali Alessandro , Sangalli Giancarlo , Tamellini Lorenzo , Todeschini Sara 
Published: April 2023

AbstractGroundwater flow modeling is commonly used to calculate groundwater heads, estimate groundwater flow paths and travel times, and provide insights into solute transport processes within an aquifer. However, the values of input parameters that drive groundwater flow models are often highly uncertain due to subsurface heterogeneity and geologic complexity in combination with lack of measurements/unreliable measurements. This uncertainty affects the accuracy and reliability of model outputs. Therefore, parameters’ uncertainty must be quantified before adopting the model as an engineering tool. In this study, we model the uncertain parameters as random variables and use a Bayesian inversion approach to obtain a posterior, data-informed, probability density function (pdf) for them: in particular, the likelihood function we consider takes into account both well measurements and our prior knowledge about the extent of the springs in the domain under study. To keep the modelistic and computational complexities under control, we assume Gaussianity of the posterior pdf of the parameters. To corroborate this assumption, we run an identifiability analysis of the model: we apply the inversion procedure to several sets of synthetic data polluted by increasing levels of noise, and we determine at which levels of noise we can effectively recover the “true value” of the parameters. We then move to real well data (coming from the Ticino River basin, in northern Italy, and spanning a month in summer 2014), and use the posterior pdf of the parameters as a starting point to perform an uncertainty quantification analysis on groundwater travel-time distributions.
An Image-Based Computational Fluid Dynamics Study of Mitral Regurgitation in Presence of Prolapse
Authors: Bennati Lorenzo , Vergara Christian , Giambruno Vincenzo , Fumagalli Ivan , Corno Antonio Francesco , Quarteroni Alfio , Puppini Giovanni , Luciani Giovanni Battista 
Published: April 2023

Abstract
Purpose
In this work we performed an imaged-based computational study of the systolic fluid dynamics in presence of mitral valve regurgitation (MVR). In particular, we compared healthy and different regurgitant scenarios with the aim of quantifying different hemodynamic quantities.

Methods
We performed computational fluid dynamic (CFD) simulations in the left ventricle, left atrium and aortic root, with a resistive immersed method, a turbulence model, and with imposed systolic wall motion reconstructed from Cine-MRI images, which allowed us to segment also the mitral valve. For the regurgitant scenarios we considered an increase of the heart rate and a dilation of the left ventricle.

Results
Our results highlighted that MVR gave rise to regurgitant jets through the mitral orifice impinging against the atrial walls and scratching against the mitral valve leading to high values of wall shear stresses (WSSs) with respect to the healthy case.

Conclusion
CFD with prescribed wall motion and immersed mitral valve revealed to be an effective tool to quantitatively describe hemodynamics in case of MVR and to compare different regurgitant scenarios. Our findings highlighted in particular the presence of transition to turbulence in the atrium and allowed us to quantify some important cardiac indices such as cardiac output and WSS.
Optimization and modelling of Pb (II) and Cu (II) adsorption onto red algae (Gracilaria changii)-based activated carbon by using response surface methodology
Authors: Isam Mubeen , Baloo Lavania , Chabuk Ali , Majdi Ali , Al-Ansari Nadhir 
Published: April 2023

AbstractActivated carbon obtained from red algae Gracilaria changii was used as an adsorbent to remove Pb (II) and Cu (II) from an aqueous solution. The raw red algae were first impregnated with phosphoric acid, followed by thermal activation. The Box–Behnken design was used to optimize the activation process. The optimum activation parameters were 84%, 650 °C, and 175 min for acid concentration, activation temperature, and activation time, respectively. The obtained activated carbon had a high surface area of 867 m2/g. The removal of Pb (II) and Cu (II) was evaluated using a batch adsorption study. The effect of solution pH on the removal of metal ions was investigated within the range of 2–7. The effect of three important adsorption parameters (initial metal ion concentration, adsorbent dosage, and contact time) was analyzed using central composite design. The optimum removal of Pb (II) and Cu (II) was 76% and 36%, respectively. The adsorption kinetics obeyed the pseudo-second-order model, while the adsorption isotherm obeyed the Langmuir model.
The state of infectious disease training in Germany before introduction of the new board certification in internal medicine and infectious diseases: past experience and future expectations
Authors: Bischoff Jenny , Schneitler Viktoria , Duettmann Wiebke , Fuchs Andre , Schneitler Sophie 
Published: April 2023

Abstract
Purpose
Recently, the German Medical Association introduced a new board certification in Internal Medicine and Infectious Diseases (ID). Accompanying, current experience with ID training and expectations for the new curriculum were assessed.

Methods
After the development of a digital survey covering four main areas with 59 questions, it was distributed via the German Society for Infectious Diseases (DGI) and other networks following a snowball principle. Participation was carried out digitally in a web-based application.

Results
Between December 2021 and February 2022, 300 datasets were included. 38.9% (114/293) of respondents had completed the additional training in ID. Of those, 54.0% (61/113) were concerned about recognition of previous training certification in the future after the establishment of the new sub-specialization. Overall, 78.5% (135/172) of respondents were satisfied or rather satisfied with the qualification gained through their training, but 8.7% (15/172) felt poorly prepared by their ID training. With regard to the inclusion of microbiology or antimicrobial stewardship (AMS) training into the new ID training curriculum, 84.6% (254/300) and 87.7% (263/300) of participants, respectively, desired an integration. Only 30.8% (53/172) felt sufficiently supported by their employer regarding childcare and 51.7% (89/172) reported missing support for scientific commitment.

Conclusion
Overall, ID training in Germany seems satisfactory so far, but there is uncertainty about future recognition. Participants find that AMS and microbiology training should be integrated into new ID training curricula. New concepts regarding the compatibility of childcare and career as well as the support of scientific commitment seem essential to attract young professionals to the field.
Insights into automation of construction process using parallel-kinematic manipulators
Authors: Klöckner M. , Haage M. , Eriksson H. , Malm H. , Nilsson K. , Robertsson A. , Andersson R. 
Published: April 2023

AbstractThis article discusses challenges, experiences and lessons learned so far while transforming a masonry build system based mostly on manual labour into a robot automated build system. Our motivation for selection of this masonry process is to try out how robot automation could impact the architects in their design work by providing a tool to directly manipulate wall expression down to individual brick level. Such manipulation is often much too costly for manual labour today. Moreover, masonry is a challenging application to automate. Understanding the manual processes involved and transforming them into automation equivalents faces several challenges; among them handling and distribution of the different materials involved, selection of tooling, sensing for handling of variation and digital tooling for the programming of the process. A novel parallel-kinematic manipulator (PKM) with computerized numerical control (CNC) is used as target for experiments, because the performance properties in stiffness, workspace and accuracy will allow us to extend work into further construction processes involving heavy and dirty manual labour.
Lessons from Developing Multimedia Learning Materials for the Digital Generation
Authors: Herrmann Jessica E. , Spielman Susie , Venook Ross , Yock Paul , Denend Lyn 
Published: April 2023

AbstractRecognizing that traditional textbooks on need-driven health technology innovation were increasingly misaligned with the needs of today’s undergraduate biomedical engineering students and the faculty who teach them, we initiated an effort to develop new learning materials for this audience. To guide our efforts, we conducted literature searches on best practices in the development of online content and engaging digital learners (primarily Gen-Z). We further held a series of discussions with biomedical engineering students and instructors at universities across the United States. This input led us to the development of a set of modular, online, multimedia learning materials specifically designed for the new generation of undergraduate learners. In this article, we present the key decisions that helped shape the project. We also share the results of feedback surveys and focus groups that shed light on how the materials have been preliminarily received. Finally, we reflect on challenges, opportunities, and lessons from this project that may be helpful to other initiatives focused on the creation of multimedia content for the digital generation.
Reduce methane emission from rice paddies by man-made aerenchymatous tissues
Authors: Yuan Zhao-Feng , Zhou Yujie , Chen Zheng , Tang Xianjin , Wang Yanfen , Kappler Andreas , Xu Jianming 
Published: April 2023

AbstractMethane is the second most important greenhouse gas after carbon dioxide, and 8–11% is emitted from paddy fields. Methanogenic microbial processes in water-saturated soils can be alleviated through the oxygenation of soils, which may hamper methane production and emissions in paddies. Here, by mimicking O2 release from rice roots, we report the use of man-made (i.e., silicone tube-based) aerenchymatous tissues (MAT) to continuously release O2 to abate methane emission from paddies. High O2-releasing rates (such as 5 kg O2/ha/d) can be easily achieved by adjusting MAT density (e.g., 0.2 m2 tube/m2 soil) and its inner air pressure (e.g., 25 kPa). Following deployment, MAT significantly increased soil redox potential (from -150 mV to -88.6 mV) and induced active iron redox cycling. This decreased the availability of organic substrates of methanogens and therefore dramatically reduced their abundance (-25.1% active mcrA gene). We quantified the decrease in methane emission both in mesocosms and paddy field trials and found in both setups that ~ 50% of methane emission was reduced. Moreover, we showed that the performance of MAT can be further improved by simply increasing the air pressure in MAT (e.g., -74.2% methane emission at 200 kPa air pressure). This work provides a powerful and sustainable method for mitigating methane emission from rice paddies.
Graphical Abstract
Enthalpy balance theory unifies diverse glacier surge behaviour
Authors: Benn Douglas I. , Hewitt Ian J. , Luckman Adrian J. 
Published: April 2023

AbstractIt is commonly asserted that there are two distinct classes of glacier surges: slow, long-duration ‘Svalbard-type’ surges, triggered by a transition from cold- to warm-based conditions (thermal switching), and fast, shorter-duration ‘Alaska-type’ surges triggered by a reorganisation of the basal drainage system (hydraulic switching). This classification, however, reflects neither the diversity of surges in Svalbard and Alaska (and other regions), nor the fundamental dynamic processes underlying all surges. We argue that enthalpy balance theory offers a framework for understanding the spectrum of glacier surging behaviours while emphasising their essential dynamic unity. In this paper, we summarise enthalpy balance theory, illustrate its potential to explain so-called ‘Svalbard-type’ and ‘Alaska-type’ surges using a single set of principles, and show examples of a much wider range of glacier surge behaviour than previously observed. We then identify some future directions for research, including strategies for testing predictions of the theory against field and remote sensing data, and priorities for numerical model development.
Development and implementation of “handshake rounds”: An antibiotic stewardship intervention for hospitalized adult patients with hematologic malignancies
Authors: Gorsline Chelsea A. , Miller Ryan M. , Bobbitt Laura J. , Satyanarayana Gowri , Baljevic Muhamed , Staub Milner B. O. 
Published: April 2023

Abstract

Objective:
To design and implement “handshake rounds” as an antibiotic stewardship intervention to reduce inpatient intravenous (IV) antibiotic use in patients with hematologic malignancies.

Design:
Quasi-experimental analysis of antibiotic use (AU) and secondary outcomes before and and after handshake rounds were implemented.

Setting:
Quaternary-care, academic medical center.

Patients:
Hospitalized adults with hematologic malignancies receiving IV antibiotics.

Methods:
We performed a retrospective review of a preintervention cohort prior to the intervention. A multidisciplinary team developed criteria for de-escalation of antibiotics, logistics of handshake rounds, and outcome metrics. Eligible patients were discussed during scheduled handshake rounds between a hematology–oncology pharmacist and transplant–infectious diseases (TID) physician. Prospective data were collected over 30 days in the postintervention cohort. Due to small sample size, 2:1 matching was used to compare pre- to and postintervention AU. Total AU in days of therapy per 1,000 patient days (DOT/1,000 PD) was reported. Mean AU per patient was analyzed using Wilcoxon rank-sum test. A descriptive analysis of secondary outcomes of pre- and postintervention cohorts was performed.

Results:
Total AU was substantially lower after the intervention, with 517 DOT/1,000 PD compared to 865 DOT/1,000 PD before the intervention. There was no statistically significant difference in the mean AU per patient between the 2 cohorts. There was a lower rate of 30-day mortality in the postintervention cohort and rates of ICU admissions were similar.

Conclusions:
Conducting handshake rounds is a safe and effective way to implement an antibiotic stewardship intervention among high-risk patient population such as those with hematologic malignancies.
Estimated daily intake and health risk assessment of toxic elements in infant formulas
Authors: Demir Tuğba , Ağaoğlu Sema 
Published: April 2023

AbstractIn this study, the heavy metal (Al, Mn, Co, Cu, Zn, As, Se, Cd, Sn, Pb and Hg) concentrations were determined in a total of seventy-two infant formula samples manufactured by sixteen different brands in Türkiye. During the analyses, inductively coupled plasma MS was used in evaluating the nutritional profile and the toxicological risk associated with the consumption of these products. Given the analysis results, the highest Pb content was found in milk-based ‘beginner’ formulas (0–6 months, three samples) packed in metal containers. The highest concentration of Mn was found in powdered infant formula (Brand 3) that is suitable for 9–12-month-olds. Mn level was found to be above the limit values in nine samples (12·5 %). Cd level exceeded the limit values in two infant formula samples of Brand 3 (0·038 µg/g) and Brand 15 (0·023 µg/g). Therefore, the mean Cd concentration found here reaches the maximum limit set by the European Union commission legislation. Cu was detected in all infant formulas. The highest concentration was determined in Brand 1 (9–12 months, seven samples) and found to be 2·637 (sd 1·928) µg/g. This value is much higher than the reference values set in the national and international standards. Based on the results achieved here, the estimated daily intake (EDI) and target hazard quotient values for all the metals in infant formulas were found lower than < 1. These findings suggest that the baby foods examined would not pose any health risk. The daily intakes exceeding the baby nutrition values recommended by the WHO would pose health risk since they would exceed the EDI levels.
COVID-19 after two years: trajectories of different components of mental health in the Spanish population
Authors: Bayes-Marin I. , Cabello-Toscano M. , Cattaneo G. , Solana-Sánchez J. , Fernández D. , Portellano-Ortiz C. , Tormos J. M. , Pascual-Leone A. , Bartrés-Faz D. 
Published: April 2023

Abstract

Aims
Our study aimed to (1) identify trajectories on different mental health components during a two-year follow-up of the COVID-19 pandemic and contextualise them according to pandemic periods; (2) investigate the associations between mental health trajectories and several exposures, and determine whether there were differences among the different mental health outcomes regarding these associations.

Methods
We included 5535 healthy individuals, aged 40–65 years old, from the Barcelona Brain Health Initiative (BBHI). Growth mixture models (GMM) were fitted to classify individuals into different trajectories for three mental health-related outcomes (psychological distress, personal growth and loneliness). Moreover, we fitted a multinomial regression model for each outcome considering class membership as the independent variable to assess the association with the predictors.

Results
For the outcomes studied we identified three latent trajectories, differentiating two major trends, a large proportion of participants was classified into ‘resilient’ trajectories, and a smaller proportion into ‘chronic-worsening’ trajectories. For the former, we observed a lower susceptibility to the changes, whereas, for the latter, we noticed greater heterogeneity and susceptibility to different periods of the pandemic. From the multinomial regression models, we found global and cognitive health, and coping strategies as common protective factors among the studied mental health components. Nevertheless, some differences were found regarding the risk factors. Living alone was only significant for those classified into ‘chronic’ trajectories of loneliness, but not for the other outcomes. Similarly, secondary or higher education was only a risk factor for the ‘worsening’ trajectory of personal growth. Finally, smoking and sleeping problems were risk factors which were associated with the ‘chronic’ trajectory of psychological distress.

Conclusions
Our results support heterogeneity in reactions to the pandemic and the need to study different mental health-related components over a longer follow-up period, as each one evolves differently depending on the pandemic period. In addition, the understanding of modifiable protective and risk factors associated with these trajectories would allow the characterisation of these segments of the population to create targeted interventions.