bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress
Authors: Fernández‐Alfara Marcos , Sibilio Annarita , Martin Judit , Tusquets Uxó Elsa , Malumbres Marina , Alcalde Victor , Chanes Verónica , Cañellas‐Socias Adrià , Palomo‐Ponce Sergio , Batlle Eduard , Méndez Raúl 
Published: March 2023

AbstractTumor growth is influenced by a complex network of interactions between multiple cell types in the tumor microenvironment (TME). These constrained conditions trigger the endoplasmic reticulum (ER) stress response, which extensively reprograms mRNA translation. When uncontrolled over time, chronic ER stress impairs the antitumor effector function of CD8 T lymphocytes. How cells promote adaptation to chronic stress in the TME without the detrimental effects of the terminal unfolded protein response (UPR) is unknown. Here, we find that, in effector CD8 T lymphocytes, RNA‐binding protein CPEB4 constitutes a new branch of the UPR that allows cells to adapt to sustained ER stress, yet remains decoupled from the terminal UPR. ER stress, induced during CD8 T‐cell activation and effector function, triggers CPEB4 expression. CPEB4 then mediates chronic stress adaptation to maintain cellular fitness, allowing effector molecule production and cytotoxic activity. Accordingly, this branch of the UPR is required for the antitumor effector function of T lymphocytes, and its disruption in these cells exacerbates tumor growth.
Uptake‐independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates
Authors: Toniolo Chiara , Dhar Neeraj , McKinney John D 
Published: March 2023

AbstractMycobacterium tuberculosis (Mtb) infection is initiated by inhalation of bacteria into lung alveoli, where they are phagocytosed by resident macrophages. Intracellular Mtb replication induces the death of the infected macrophages and the release of bacterial aggregates. Here, we show that these aggregates can evade phagocytosis by killing macrophages in a contact‐dependent but uptake‐independent manner. We use time‐lapse fluorescence microscopy to show that contact with extracellular Mtb aggregates triggers macrophage plasma membrane perturbation, cytosolic calcium accumulation, and pyroptotic cell death. These effects depend on the Mtb ESX‐1 secretion system, however, this system alone cannot induce calcium accumulation and macrophage death in the absence of the Mtb surface‐exposed lipid phthiocerol dimycocerosate. Unexpectedly, we found that blocking ESX‐1‐mediated secretion of the EsxA/EsxB virulence factors does not eliminate the uptake‐independent killing of macrophages and that the 50‐kDa isoform of the ESX‐1‐secreted protein EspB can mediate killing in the absence of EsxA/EsxB secretion. Treatment with an ESX‐1 inhibitor reduces uptake‐independent killing of macrophages by Mtb aggregates, suggesting that novel therapies targeting this anti‐phagocytic mechanism could prevent the propagation of extracellular bacteria within the lung.
Carotene Synthesis Changes of Rhodotorula Aurantiaca Indicator Yeasts in the Presence of Copper (II) Salts
Authors: Krupiei Krystyna , Kravchenko Hlib 
Published: March 2023

Rhodotorula aurantiaca yeasts are ubiquitous microorganisms found in water, soil, plants, etc. Since the main requirement of an indicator organism is the wide occurrence in nature, this species can be an informative bioindicator of the ecological state of the environment. The aim was to study the influence of Cu (II) compounds on the color of carotenoid pigments intensity of two Rh. aurantiaca strains (Y-1193 and Y-1195).
Rh. aurantiaca Y-1193 strain was more susceptible to the compounds of Cu (II) than Rh. aurantiaca Y-1195. Thus, due to the action of Copper (II) chloride in a concentration of 100 mg/dm3 and Copper (II) sulfate in a concentration of 200 mg/dm3, the synthesis of pigments in Rh. aurantiaca Y-1193 was inhibited, which was 2 and 2.5 times, respectively, lower than concentrations at which the Rh. aurantiaca Y-1195 strain lost its ability to form carotenoid pigments. The most toxic effect on Rh. aurantiaca yeast was caused by the compound Cu(NO3)2. There was no cell growth at a concentration of 200 mg/dm3 of Cu2+ ions, and the concentration interval between the loss of pigments and growth retardation was also not detected. dE (the difference in the intensity of pigment accumulation of microorganisms) yielded a greater value when the difference between control and experimental yeast samples was bigger. Thus, for intensively pigmented colonies, this index varied from 7.4 to 9.6 c. u., however, for non-pigmented colonies under the influence of Copper (II) compounds, dE was in the range from 19.8 to 21.5 c. u. To confirm the effectiveness of using the scale for visual assessment of pigment accumulation for studied microorganisms, the quantitative content of carotenoids in Rh. aurantiaca Y-1193 strain was determined by spectrophotometric methods. When comparing the visual assessment of pigment accumulation in yeast and the concentration of carotenoids in cells, a strong correlation was established (r = 0.9). The dependence is statistically significant (p<0.05). Therefore, the carotenogenic culture of Rh. aurantiaca Y-1193 can be recommended for use in bioindication studies of water contamination with Cu (II) compounds. The prospect of further research is to study the influence of other compounds of the I and II hazard classes on the intensity of pigment accumulation of yeasts in the Rhodotorula genus.
Implementing Social Risk Screening and Referral to Resources in the NICU
Authors: Cordova-Ramos Erika G. , Jain Chandni , Torrice Vanessa , McGean Maggie , Buitron de la Vega Pablo , Burke Judith , Stickney Donna , Vinci Robert J. , Drainoni Mari-Lynn , Parker Margaret G. 
Published: March 2023

OBJECTIVE
Social risk screening is recommended by the American Academy of Pediatrics, but this practice is underutilized in NICUs. To address this gap in social care, we aimed to increase rates of: (1) systematic social risk screening and (2) connection with community resources, each to ≥50% over a 14-month period.

METHODS
We conducted a quality improvement initiative from November 2020 to January 2022. We adapted a screening tool and used Plan-Do-Study-Act cycles to integrate screening and referral to resources into clinical workflow. Primary outcome measures included the percentage of (1) families screened and (2) connection with resources. We examined screening by maternal race/ethnicity and primary language. Process measures were (1) time from admission to screening and (2) percentage of referrals provided to families reporting unmet needs and requesting assistance. We used statistical process control to assess change over time and χ2 tests to compare screening by race/ethnicity and language.

RESULTS
The rates of systematic screening increased from 0% to 49%. Among 103 families screened, 84% had ≥1, and 64% had ≥2 unmet needs, with a total of 221 needs reported. Education, employment, transportation, and food were the most common needs. Screening rates did not vary by race/ethnicity or language. Among families requesting assistance, 98% received referrals. The iterative improvement of a written resource guide and community partnerships led to increased rates of connection with resources from 21% to 52%.

CONCLUSION
Leveraging existing staff, our social risk screening and referral intervention built the capacity to address the high burden of unmet needs among NICU families.
ОСОБЛИВОСТІ ТЕХНОЛОГІЇ ВИГОТОВЛЕННЯ РУКАВІВ СТИКУВАННЯ СИСТЕМИ ТЕРМОСТАТУВАННЯ КОСМІЧНОЇ РАКЕТИ «ЦИКЛОН-4»
Authors: Khorolskyi M. , Bigun S. 
Published: March 2023

Розглянуті особливості виготовлення гумових гофрованих рукавів для вузлів стикування системи термостатування космічних ракет. Ці особливості пов’язані із властивостями гуми як конструкційного матеріалу і особливостями технології виготовлення великогабаритних гумотехнічних виробів, до яких відносяться зазначені гумові рукави, формовим способом. Оскільки технологія і спосіб їх виготовлення нерозривно пов’язані з конструкцією технологічного оснащення, розглянуто принципово новий підхід при виготовленні гумових рукавів високої якості декількох типорозмірів одного діаметра різної довжиии в одній прес-формі з можливістю її переналагоджування. Новий підхід полягає в тому, що в прес-формі для виготовлення відповідного гумового рукава в верхній і нижній плитах з внутрішньої сторони вздовж осі попарно симетрично установлюють змінні секційні сегменти, а на суцільну частину розбірного стрижня установлюють змінні діаметральні вкладиші, з допомогою яких забезпечується формоутворення гумового гофрованого рукава відповідних розмірів одного діаметра. При цьому центри поверхонь виступів і западин вкладишів повинні співпадати в площині з відповідними центрами поверхонь западин і виступів змінних секційних сегментів у нижній та верхній плитах прес-форми. Геометричні розміри змінних секційних сегментів та діаметральних вкладишів залежить від геометричних розмірів кожного рукава і кількості гофр на ньому в межах одного діаметра. Це дає можливість мінімізувати витрати на виготовлення та ремонт технологічного оснащення за рахунок зменшення його кількості та підвищити ремонтопридатність технологічного оснащення і його якість за рахунок підвищення технологічності виготовлення і ремонту деталей прес-форми, що забезпечують формоутворення гумового гофрованого рукава для вузлів стикування системи термостатування. На спосіб виготовлення рукавів стикування трубопроводу системи термостатування отримано патент на корисну модель від 27.07.2020 року №143346. Показана можливість підвищення продуктивності праці з виготовлення гумових гофрованих рукавів для системи термостатування за рахунок виготовлення другого взаємозамінного стрижня і його підготовки до експлуатації в процесі здійснення технологічного процесу.
Frequencies of application and dilution of nutrient solution in hydroponic cultivation of arugula
Authors: Santos Jenyffer da Silva Gomes , Silva Alexsandro Oliveira da , Lacerda Claudivan Feitosa de , Costa Raimundo Nonato Távora , Silva Geronimo Ferreira da , Putti Fernando Ferrari 
Published: March 2023

Nutrient solution formulation such as irrigation frequency is fundamental for the success of hydroponic cultivation, since the absorption of nutrients from the nutrient solution is a selective and dynamic process, in which the relative proportion between nutrients in the solution stands out. Thus, the present experiment was conducted to evaluate the production and development of arugula in hydroponic cultivation subjected to different dilutions and frequencies of application of the nutrient solution. The experiments were carried out in a randomized blocks design, with four replicates. A split-plot scheme in a 5 x 2 factorial arrangement was used, which consisted of five dilutions based on the electrical conductivity of the nutrient solution (ECsol: 2.00 (control), 1.81, 1.62, 1.40, and 1.30 dS m-1, corresponding to 100, 90, 80, 70, and 65% concentrations, respectively) and two application frequencies (variable and fixed), totaling 40 experimental plots, in three production cycles. Shoot fresh mass, shoot dry mass, leaf area, leaf area index, number of leaves, plant height, relative chlorophyll index and macronutrients were analyzed. Regarding shoot fresh mass, there was an increase with the concentration of the nutrient solution, reaching a maximum of 15.52 and 8.40 g plant-1, with nutrient solution was of 1.77 dS m-1 (first cycle) and 1.88 dS m-1 (second cycle). Using only 90% of the recommended nutrient solution is the most appropriate from the commercial point of view, as it led to maximum potential in relation to production, using a smaller number of inputs.
Life Years Lost in Children with Kidney Failure: A Binational Cohort Study with Multistate Probabilities of Death and Life Expectancy
Authors: Wyld Melanie L. , De La Mata Nicole L. , Hedley James , Kim Siah , Kelly Patrick J. , Webster Angela C. 
Published: March 2023

Significance Statement
In children with kidney failure, little is known about their treatment trajectories or the effects of kidney failure on lifetime survival and years of life lost, which are arguably more relevant measures for children. In this population-based cohort study of 2013 children who developed kidney failure in Australia and New Zealand, most children were either transplanted after initiating dialysis (74%) or had a preemptive kidney transplant (14%). Life expectancy increased with older age at kidney failure, but more life years were spent on dialysis than with a functioning transplant. The expected (compared with the general population) number of life years lost ranged from 16 to 32 years, with female patients and those who developed kidney failure at a younger age experiencing the greatest loss of life years.

Background
Of the consequences of kidney failure in childhood, those rated as most important by children and their caregivers are its effects on long-term survival. From a life course perspective, little is known about the experience of kidney failure treatment or long-term survival.

Methods
To determine expected years of life lost (YLL) and treatment trajectory for kidney failure in childhood, we conducted a population-based cohort study of all children aged 18 years or younger with treated kidney failure in Australia (1980–2019) and New Zealand (1988–2019).We used patient data from the CELESTIAL study, which linked the Australian and New Zealand Dialysis and Transplant registry with national death registers. We estimated standardized mortality ratios and used multistate modeling to understand treatment transitions and life expectancy.

Results
A total of 394 (20%) of 2013 individuals died over 30,082 person-years of follow-up (median follow-up, 13.1 years). Most children (74%) were transplanted after initiating dialysis; 14% (18% of male patients and 10% of female patients) underwent preemptive kidney transplantation. Excess deaths (compared with the general population) decreased dramatically from 1980 to 1999 (from 41 to 22 times expected) and declined more modestly (to 17 times expected) by 2019. Life expectancy increased with older age at kidney failure, but more life years were spent on dialysis than with a functioning transplant. The number of YLL ranged from 16 to 32 years, with the greatest loss among female patients and those who developed kidney failure at a younger age.

Conclusions
Children with kidney failure lose a substantial number of their potential life years. Female patients and those who develop kidney failure at younger ages experience the greatest burden.
History and contribution of Indians to orthodotics: A review
Authors: Rahul N A , Ahmed Nausheer , Younus A Abrar , Aymen Uroosa 
Published: March 2023

This article presents the evolution of dentistry and in particular orthodontics, in India and contribution of Indians to the field of orthodontics. We have come a long way since dental education was first introduced to us Indians, the wave of change brought about by the most esteemed and respectable pioneers of our profession, have led us to form a strong dental community in this world of tough competition. The pioneer of Indian dental education by Dr. H.D. Merchant, who gave first series of lectures in orthodontics. This article also prevents the work of great achievers of orthodontia, who have helped us raise the level of ‘Indian Orthodontics” and have enabled us to soar to greater heights.So, this review article presenting briefly on contributions of Indians to the field of orthodontics from the era of introducing orthodontics as a branch of specilisation of dentistry in India to recent achievements in this field.
Perioperative Management of Patients with Asthma-COPD Overlap Syndrome - Where Do We Stand? A Case Report-Based Discussion
Authors: Reazaul Karim Habib Md , Kumar Panda Chinmaya , Manasa Rapeti Kalyani , Jayanti Bodra Nivedita , Rajendran Pragadeshwaran 
Published: March 2023

Background: Postoperative pulmonary complications (PPCs) are associated with a significant morbidity and mortality; prevention and management strategies depend greatly on the patients’ comorbid conditions. Chronic Obstructive Pulmonary Disease (COPD) is a well-known risk factor for PPCs, but controlled Asthma does not appear to be so. On the other hand, the role of Asthma-COPD Overlap Syndrome (ACOS) as a risk for PPCs is yet to be studied. While there is a guidance for the perioperative risk reduction and management of COPD and Asthma, specific guidance for ACOS is also lacking. As a consequence, physicians tailor their management by considering both the components.
Case presentation: We present a case of a 74-year-old man with ACOS, diagnosed with invasive bladder carcinoma. He was taken for laparoscopic radical cystectomy and ileal conduit. Although he had an uneventful surgery, we lost him on the seventh postoperative day due to multiple complications, including PPCs.
Conclusion: The case highlights the need for considering the ACOS separately as a risk and calls for a specific roadmap for perioperative management.

Asthma-COPD Overlap Syndrome patients appear to be at high risk of PPCs
There is a lack of evidence-based guidance and literature to tailor the management of such patients to reduce the perioperative risks for PPCs
It is high time to delineate the ACOS patients from Asthma and COPD, study them in context to PPCs and perioperative outcome so that specific guidance can be developed.
Symulowana intymność w relacjach typu „friends with benefits”
Authors: Bieńko Mariola 
Published: March 2023

W narracji biograficznej młodych dorosłych przedłużenie dojrzewania to świadome oddzielenie życia seksualnego od prokreacji i małżeństwa. Kultura „podrywu”, obrazująca wyraźną zmianę w kierunku akceptacji przez młodych dorosłych w zachodnich społeczeństwach przygodnego, nierelacyjnego seksu, wywołuje znaczne zainteresowanie w naukach społecznych. Prezentowany artykuł definiuje i opisuje społeczny konstrukt „przyjaźni z korzyścią/bonusem” definiowanej jako relacja, w której przyjaciele przeciwnej płci utrzymują ze sobą powtarzalne kontakty seksualne, wykluczają jednak romantyczne uczucie i zaangażowanie. Związki te postrzegane są jako krótkoterminowe strategie dobierania się w pary, niezwiązane z planem stworzenia stałego związku.
Celem artykułu jest przedstawienie wyników badań jakościowych opartych na 42 na wpół ustrukturalizowanych wywiadach z kobietami i mężczyznami w wieku od 27 do 38 lat, zamieszkującymi z rodzicami w Warszawie. Analiza skupia się na zobrazowaniu stosunku młodych dorosłych do friendship with benefits jako jednej z form realizowanych przez nich samych relacji w intymnym związku, jak i oceny tego nowego wymiaru relacyjności w środowisku ich rówieśników.
Do Computerized False Belief Tasks Impact Mentalizing Ability in People with Williams Syndrome?
Authors: Hsu Ching-fen , Rao Shi-yu 
Published: March 2023

Background: People with Williams syndrome (WS) are characterized with hypersociability, fluency in languages, and advantageous face-processing skills, leading to the proposal of a social module. Previous studies on the mentalizing abilities of people with WS using two-dimensional pictures and mindreading from eyes, including normal-like, delayed, and deviant behaviors, have yielded mixed results. This study thus examined the mentalizing ability of people with WS through structured computerized animations of false belief tasks to investigate whether inferences about other people’s minds can be improved in this population.
Method: Participants were shown animations with unexpected location and content changes. After viewing each animation, participants had to answer four types of questions: character identification, reality, memory, and false belief. Their responses were recorded and analyzed.
Results: Comprehension of false belief was observed in 4-year-old healthy children, whereas children with WS showed unsuccessful comprehension of false belief (until they attained a mental age of 5.3 years), suggesting an improvement in theory of mind resulting from viewing structured computerized animations. This age is earlier than that reported by previous studies for using theory of mind to pass false belief tests (8.5 years old), even challenging the age at which individuals failed to pass the tests (12.10 years old).
Conclusions: Structured computerized animations enhanced the mentalizing ability of people with WS to a certain extent. Compared to the typically developing controls, people with WS presented with a lower developmental level in processing false belief tasks. The educational implication of this study is to develop computerized social skills interventions for people with WS.
Women and Resilience on Pandemic Covid-19 Disaster: Feminist Participatory Action (FPA)
Authors: Lestariyanti Elina , Hidayatullah Ahmad Fauzan , Saptaningtyas Haryani , Rohman Isa Aulia 
Published: March 2023

<p class="06IsiAbstrak"><em>Women are the group that receives double impacts than men in disaster situations, including the Covid-19 pandemic. On the other hand, women have bigger potentials to participate in the implementation of the Covid-19 pandemic disaster management. This article explores women's resilience initiatives in the face of the Covid-19 pandemic disaster situation. This study used a descriptive narrative method to explain the initiative of the women community assisted by LRC-KJHAM in Central Java, Indonesia. The results showed that the women's community through the feminist participatory action (FPA) took the initiative and adaptive activities during the Covid-19 pandemic, including through education consist online discussions, counseling and campaigns and promote economic empowerment such as online markets, MSMEs, health protocol equipment, women's planting movements). In this article, Feminists Participatory Action means the collection of some actions which is based on the data collected by vulnerable women and following by distributing some actions as part of their social assistance, such as through the provision of temporary shelters for women victims of domestic violence during the pandemic.</em></p>
Periglacial–Aeolian Polygonal Surface Structures in the Tibetan Plateau
Authors: Galanin A.A. , Klimova I.V. , Khristoforov I.I. , Wu Q. , Ze Zh. 
Published: March 2023

Abstract—The surface pattern of permafrost area in the Tibetan Plateau, with 15–20 m polygons, resembles the patterned ground of the Arctic periglacial loess plains in northeastern Eurasia and North America. However, unlike the Arctic plains, it consists of semi-stabilized modern sand dunes, up to 2.5–3.0 m high, and U-shaped epigenetic ice wedge casts inherited from an ancient polygonal network on the surface of a 10–12-m terrace of the Yangtze River. The polygonal dunes and the U-shaped sand wedges were studied in the Yangtze head-waters in the vicinity of the high-altitude research station Bei-Lu-Xe. The polygons have desert pavement floors with ventifacts, composed of Late Pleistocene alluvial gravel and debris. The dunes and wedges consist of well sorted quartz-carbonate sand with an average grains size of 2.0–2.2 mm. Ground Penetrating Radar surveys in the area revealed the permafrost table at depths varying from 2 to 4 m below the dunes. The polygonal dunes may have formed by biogenic-aeolian deposition over an ancient system of ice wedges.