bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computerized clinical decision support systems for prescribing in primary care: main characteristics and implementation impact—protocol of an evidence and gap map
Authors: Acosta-García Héctor , Ferrer-López Ingrid , Ruano-Ruiz Juan , Santos-Ramos Bernardo , Molina-López Teresa 
Published: December 2022

Abstract
Background
Computerized clinical decision support systems are used by clinicians at the point of care to improve quality of healthcare processes (prescribing error prevention, adherence to clinical guidelines, etc.) and clinical outcomes (preventive, therapeutic, and diagnostics). Attempts to summarize results of computerized clinical decision support systems to support prescription in primary care have been challenging, and most systematic reviews and meta-analyses failed due to an extremely high degree of heterogeneity present among the included primary studies. The aim of our study will be to synthesize the evidence, considering all methodological factors that could explain these differences, and build an evidence and gap map to identify important remaining research questions.

Methods
A literature search will be conducted from January 2010 onwards in MEDLINE, Embase, the Cochrane Library, and Web of Science databases. Two reviewers will independently screen all citations, full text, and abstract data. The study methodological quality and risk of bias will be appraised using appropriate tools if applicable. A flow diagram with the screened studies will be presented, and all included studies will be displayed using interactive evidence and gap maps. Results will be reported in accordance with recommendations from the Campbell Collaboration on the development of evidence and gap maps.

Discussion
Evidence behind computerized clinical decision support systems to support prescription use in primary care has so far been difficult to be synthesized. Evidence and gap maps represent an innovative approach that has emerged and is increasingly being used to address a broader research question, where multiple types of intervention and outcomes reported may be evaluated. Broad inclusion criteria have been chosen with regard to study designs, in order to collect all available information. Regarding the limitations, we will only include English and Spanish language studies from the last 10 years, we will not perform a grey literature search, and we will not carry out a meta-analysis due to the predictable heterogeneity of available studies.

Systematic review registration
This study is registered in Open Science Framework https://bit.ly/2RqKrWp
Urban expansion of Energiewende in Germany: a systematic bibliometric analysis and literature study
Authors: Yang Peter 
Published: December 2022

Abstract
Background
Despite Germany’s world leadership of Energiewende, there have been mounting challenges, such as the slowdown of German renewable energy growth since 2017, when the Merkel administration dramatically changed the German renewable energy promotion policy from feed-in tariffs to competitive auctions. These challenges pose important research questions about whether and how an emerging urban expansion of Energiewende can serve as a vital solution to counteract the challenges to the energy transition. Answering these research questions provides a unique opportunity to explore the academic and historic foundations of the energy transition and its urban expansion, the emerging events that exemplify urban expansion, and the viable solutions this growing trend of urban expansion might be able to provide to the challenges to the German energy transition.

Methods
This paper conducted visual and manual bibliometric analyses, examined the results of case studies, and reviewed secondary literature and data on urban expansion of German Energiewende.

Results
By analyzing the bibliometric and investigative results, this paper identified political, socioeconomic, and technological challenges to Energiewende and a new trend of solar energy expansion in German cities aimed at meeting Germany’s carbon neutrality targets by 2045. The new trend of the urban expansion of the German energy transition manifests itself in the focused research efforts on identifying the vast untapped potential on new building rooftop areas in most populous German cities and/or detached and two-family houses in Germany and the recent booming of building-related solar PV and heating mandates in German cities and states, the expanding solar heating and cooling systems, and the government policy support at various levels in this urban expansion through aggressively strengthening climate and renewable energy targets.

Conclusions
In search for answers to the recent challenges of Energiewende in Germany, this paper conducted both visual and manual bibliometric analyses and applied desk research and reviews of secondary literature and data. This paper found an emerging trend of the urban expansion of Energiewende, including the awareness of the vast potential and gap of urban solarization and the enhanced urban municipal policies, actors, actions, and accomplishments of exploiting this potential. These findings were based on academic knowledge on the German energy transition and contribute to expanding this academic knowledge. To help more effectively exploit the vast potential in solarizing all German cities, especially the largest ones, this study recommends that further research more closely track the progress of this trend and apply more quantitative tools and approaches in future tracking.
Toxico-clinical study of patients poisoned with household products; a two-year cross-sectional study
Authors: Eizadi-Mood Nastaran , Lalehzar Sahar Sadat , Niknam Sara , Mahvari Razieh , Mirmoghtadaee Parisa , Meamar Rokhsareh 
Published: December 2022

Abstract
Background
Several studies worldwide have investigated household product poisoning. We conducted a toxico-clinical study on the two-year prevalence of poisoning with household products.

Methods
This cross-sectional study was performed in Khorshid Hospital, the main referral center for poisoning cases in Isfahan, affiliated to Isfahan University of Medical Sciences, Isfahan, central Iran. All patients with intentional or unintentional household substance poisoning, referring to the poisoning emergency center of the hospital, were evaluated with respect to epidemiological and toxico-clinical features and outcomes.

Results
During the study period, 5946 patients were hospitalized, of which 83 (1.39%) had been poisoned with household products including 48 (57.8%) men and 35 (42.2%) women with a mean ± SD age of 34.40 ± 17.71 years. Most patients (54.2%) were in the 20–40-year-old age group. Accidental poisoning (63.9%) was the most common type of exposure (P = 0.02) predominantly in men (57.8%, P = 0.51). The most common household products were sodium hypochlorite (32.53%) followed by petroleum hydrocarbon (21.68%). Most of the accidental poisonings (77.8%) were due to petroleum hydrocarbon. 59% of cases were poisoned at home (P < 0.0001). No patient died.

Conclusion
Household products were not common means of poisoning in our referral center. Sodium hypochlorite and petroleum hydrocarbon were the most common substances. Most of the patients were men with accidental exposure at home. Because of the availability of the household product, the frequency and outcomes may be varied in different societies.
Budget impact analysis of breast cancer medications: a systematic review
Authors: Mohammadnezhad Ghader , Sattarpour Melika , Moradi Najmeh 
Published: December 2022

Abstract
Background
Breast cancer (BC) is the most common cancer globally among women, with 2,261,419 new cases in 2020; systemic treatment may be neo-adjuvant, adjuvant, or both. BC subtype guides the standard systemic therapy administered, which consists of endocrine therapy for all HR + tumors, trastuzumab-based HER2-directed antibody therapy plus chemotherapy for all HER2 + tumors (with endocrine therapy given in addition, if concurrent HR positivity), and chemotherapy alone for the triple-negative subtype. This study aimed to identify, evaluate, and systematically review all budget impact analyses (BIAs) of BC medications worldwide.

Methods
PubMed, Scopus, and Web of Science Core Collection databases were thoroughly searched up to 26th March 2022 to identify original published studies which evaluate BIA of BC medications. ISPOR Task Force guidelines were used to assess the quality of included studies. This study was conducted and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results
In total, 17 BIAs were included in the study. About half of the studies were conducted in Europe. The results of the BIAs showed that most of the included BIAs are conducted from the payer’s perspective; they have different methodological frameworks for recommended chemotherapy, targeted therapy, and immunotherapy agents to treat BC. For the same medications, the results of budgetary effects are not consistent in diverse countries. Nine out of the 17 studies were focused on trastuzumab, in which the biosimilar form reduced costs, but the brand form increased costs, especially in a 52-week treatment period.

Conclusion
Researchers should conduct the budget impact analysis of high-value medications such as anti-tumor drugs more objectively, and the accuracy of parameters needs to be more strictly guaranteed. Furthermore, it is worthy of declaring that the budgetary impact of the same drug is not always consistent over time, so the researchers should measure access to medication in the long run.
Assessment of puberty in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis
Authors: Ghobrial Emad E. , Galal Rasha E. , Gadass Maha S. , Shaalan Yomna M. 
Published: December 2022

Abstract
Background
Growth and pubertal retardation are one of the most visible comorbidities in children with chronic kidney disease (CKD) and end-stage renal disease (ESRD) under regular hemodialysis. This study evaluated pubertal development in children and adolescents with CKD and ESRD on regular hemodialysis.

Methods
This study was carried out on 40 children with CKD and 20 with ESRD under regular hemodialysis. All patients and controls were subjected to a thorough clinical examination pubertal assessment.

Results
There was a statistically significant difference in the breast or testicular stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (50.0%, 45.0%, respectively). The CKD cases were also stages 1 and 2 (35.7%, 52.4%, respectively). The controls were in stages 3 and 4 (44.3 and 29.5%, respectively), which showed normal development for age. There was a statistically significant difference in the pubic hair stage and axillary hair stage of the three groups (P < 0.001). Most cases of ESRD were either stages 1 or 2 (55.0%, 40.0%, respectively). The CKD cases were also between stages 1 and 2 (38.1%, 52.4%, respectively), with a higher level in stage 2. Of the control group, 39.3% was stage 3, and 36.1% was stage 4, with a higher level in stage 3 proving normal development for age.

Conclusion
Pubertal growth and sexual maturation in children with CKD and ESRD are markedly affected. It is necessary to regularly follow up with children with ESRD for early detection of endocrinal complications.
Vanillic acid attenuates testicular ischemia/reperfusion injury in rats
Authors: Mentese Ahmet , Demir Selim , Kazaz Ilke Onur , Yulug Esin , Alemdar Nihal Turkmen , Demir Elif Ayazoglu , Kartal Mehmet Baris , Durmus Tenzile Beyza , Aliyazicioglu Yuksel 
Published: December 2022

Abstract
Background
Testicular torsion is an important pediatric problem and ischemia/reperfusion injury (IRI) is involved in its etiopathogenesis. Vanillic acid (VA) is a phenolic acid has strong antioxidant properties. To our knowledge, the ability of VA to reduce testicular IRI has not been previously investigated. It was therefore aimed to evaluate whether VA had a beneficial effect against testicular IRI model in rats for the first time. Twenty-four rats were segregated into four groups: sham control, torsion/detorsion (T/D), T/D + VA (50 mg/kg and 100 mg/kg). The levels of testicular oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis markers were determined using colorimetric methods. Hematoxylin–eosin staining method was used in the histopathological evaluation.

Results
Oxidative stress, inflammation, ER stress and apoptosis levels were significantly higher in testicular tissues of rats with only IRI model (p < 0.05). VA applications improved these injuries in a dose-dependent manner (p < 0.05). Moreover, it was found that the results of histological examinations supported the biochemical results to a statistically significant extent.

Conclusions
It was revealed that VA application can remove testicular IRI for the first time. This testicular protective efficacy of VA needs to be supported by more extensive preclinical studies.
An empirical investigation into people’s intention to participate in mega events tourism: applying mixture of two behavioral theoretical models
Authors: Halim Yasser Tawfik , Halim Hazem Tawfik , El-Deeb Mohamed Samy , El Sheikh Samia Adly 
Published: December 2022

AbstractThe purpose of this research is to build and evaluate a theoretical model capable of forecasting public participation in mega events. This study predicts event tourism participation using a mixed behaviour model based on a trust model and a deliberate actions model. Using data from 261 local and international visitors, structural equation modelling was engaged to examine the study hypotheses. According to the study's results, observed benefits were positively connected with people’s perspective, but observed obstacles were negatively associated, and observed benefits had a positive influence on interactive mechanism and observed obstacles had a negative influence on interactive mechanism. Additionally, the study's results suggested that individuals' intention to participate in mega events was positively influenced by their observed benefits, perspective, interactive mechanism, and normative beliefs and negatively influenced by observed obstacles. Finally, we perceived that observed risk significantly moderated the associations between observed benefits, observed obstacles and perspective, observed benefits, observed obstacles and interactive, lastly, observed benefits, observed obstacles, perspective, interactive mechanism, normative beliefs and intention to participate in events. The research's outcomes have significant hypothetical and applied effects for mega-events travel.
Dynamic Risk Stratification for Predicting Long-term Outcomes in Pediatric Differentiated Thyroid Cancers
Authors: Majeed Althaf K , Satapathy Swayamjeet , Ballal Sanjana , Bal Chandrasekhar 
Published: December 2022

Abstract

Context
The American Thyroid Association (ATA) guidelines recommend Dynamic Risk Stratification (DRS) for predicting long-term outcomes and personalizing management in adult differentiated thyroid cancers (DTCs). However, its applicability in pediatric DTCs needs to be validated.

Objective
We have attempted a validation study concerning the use of DRS in pediatric DTCs.

Methods
Data of children (age ≤18 years) with DTCs and follow-up of ≥5 years were extracted. All patients were classified according to DRS (excellent biochemical or structural incomplete responses). Univariate and multivariate analyses were done to identify factor(s) affecting disease-free survival (DFS).

Results
We included 176 pediatric patients with DTC (median age at diagnosis 15 years). All patients underwent thyroidectomy and received radioiodine as part of initial management. On the basis of clinical, biochemical, and imaging findings acquired during the first 2 years of follow-up, the DRS system divided patients into 3 response categories: excellent response in 82/176 (46.6%), biochemical incomplete response in 56/176 (31.8%), and structural incomplete response in 38/176 (21.6%) patients. The median follow-up was 10.6 years (interquartile range 7.7-15.5). Ten-year overall survival and DFS rates were 100% and 88.7%, respectively. In univariate analysis, DFS was significantly affected by extrathyroidal extension (P = .002), lymph node metastasis (P = .018), ATA initial risk stratification (P = .033), and DRS (P = .004). However, in multivariate analysis, DRS alone showed a significant association with DFS (P = .016).

Conclusion
Like adults, DRS correctly predicts long-term outcomes in pediatric DTC. In addition to ATA initial risk stratification, DRS could further refine risk in pediatric DTCs and help in planning more personalized treatment and follow-up strategies.
Stress, Anxiety, and Depression Associated With Awake Craniotomy: A Systematic Review
Authors: Mofatteh Mohammad , Mashayekhi Mohammad Sadegh , Arfaie Saman , Chen Yimin , Hendi Kasra , Kwan Angela Tian Hui , Honarvar Faraz , Solgi Arad , Liao Xuxing , Ashkan Keyoumars 
Published: December 2022

BACKGROUND:
Awake craniotomy (AC) enables real-time monitoring of cortical and subcortical functions when lesions are in eloquent brain areas. AC patients are exposed to various preoperative, intraoperative, and postoperative stressors, which might affect their mental health.

OBJECTIVE:
To conduct a systematic review to better understand stress, anxiety, and depression in AC patients.

METHODS:
PubMed, Scopus, and Web of Science databases were searched from January 1, 2000, to April 20, 2022, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline.

RESULTS:
Four hundred forty-seven records were identified that fit our inclusion and exclusion criteria for screening. Overall, 24 articles consisting of 1450 patients from 13 countries were included. Sixteen studies (66.7%) were prospective, whereas 8 articles (33.3%) were retrospective. Studies evaluated stress, anxiety, and depression during different phases of AC. Twenty-two studies (91.7%) were conducted on adults, and 2 studies were on pediatrics (8.3 %). Glioma was the most common AC treatment with 615 patients (42.4%). Awake-awake-awake and asleep-awake-asleep were the most common protocols, each used in 4 studies, respectively (16.7%). Anxiety was the most common psychological outcome evaluated in 19 studies (79.2%). The visual analog scale and self-developed questionnaire by the authors (each n = 5, 20.8%) were the most frequently tools used. Twenty-three studies (95.8%) concluded that AC does not increase stress, anxiety, and/or depression in AC patients. One study (4.2%) identified younger age associated with panic attack.

CONCLUSION:
In experienced hands, AC does not cause an increase in stress, anxiety, and depression; however, the psychiatric impact of AC should not be underestimated.
Reference Vector Assisted Candidate Search with Aggregated Surrogate for Computationally Expensive Many Objective Optimization Problems
Authors: Wang Wenyu , Shoemaker Christine A. 
Published: December 2022

Pareto-optimal sets of multiobjective optimization problems with black-box and computationally expensive objective functions are generally hard to locate within a limited computational budget, and this situation gets even worse when more than three objectives are involved. To this end, we present a novel surrogate-assisted many-objective optimization algorithm RECAS. Unlike most prior studies, the proposed algorithm is a non–evolutionary-based method, and it iteratively determines new points for expensive evaluation via a series of independent reference vector assisted candidate searches. Furthermore, to make the number of surrogates to be maintained independent of the number of objectives, in each candidate search, RECAS constructs a surrogate model in an aggregated manner to approximate the quality assessment indicator of each point rather than a certain objective function. Under some mild assumptions, this study proves that RECAS converges almost surely to the Pareto-optimal front. In the numerical experiments, the effectiveness and reliability of RECAS are examined on both DTLZ and WFG test suites with the number of objectives varying from 2 to 10. Compared with six state-of-the-art many-objective optimization algorithms, RECAS generally performs better in maintaining convergent and well-spread approximation of the Pareto-optimal front. Finally, the good performance of RECAS on two watershed simulation model calibration problems indicates its great potential in handling real-world applications. History: Accepted by Antonio Frangioni, Area Editor for Design and Analysis of Algorithms–Continuous. Funding: This work was supported by the National University of Singapore start-up grant to C.A. Shoemaker [Grant R-266-000-109-133]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplementary Information [ https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.1260 ] or is available from the IJOC GitHub software repository ( https://github.com/INFORMSJoC ) at [ http://dx.doi.org/10.5281/zenodo.7243971 ].
The Utilization Premium
Authors: Grigoris Fotis , Segal Gill 
Published: December 2022

We study the interaction of flexible capital utilization and depreciation for expected returns and investment of firms. Empirically, an investment strategy that buys (sells) equities with low (high) utilization rates earns 5% per annum. Utilization predicts excess returns beyond other production-based variables. We reconcile this novel utilization premium quantitatively using a production model. The model suggests that flexible utilization is important for matching the cross-sectional distribution of investment and stock prices jointly. A model without flexible utilization yields many counterfactuals that flexible utilization addresses by making depreciation fluctuate endogenously. Overall, utilization tightens the link between firms’ production and valuations. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4647 .
Non-Episodic Angioedema Associated with Eosinophilia after COVID-19
Authors: Harada Taku , Kosaka Shintaro , Nakai Mori 
Published: December 2022

ntroduction: Non-episodic angioedema associated with eosinophilia (NEAE) has been reported primarily in young East Asian women and is characterized by a single episode of persistent limb oedema, peripheral eosinophilia, and transient joint pain. Although there are reports of eosinophilia disease after coronavirus disease 2019 (COVID-19), the occurrence of NEAE has not been previously reported. Case description: A 29-year-old Japanese woman, with a history of allergic rhinitis and atopic dermatitis, sought a medical consultation for persisting oedema of the extremities, which developed about 2 weeks after she contracted COVID-19. Physical examination revealed symmetrical non-pitting oedema with peripheral predominance. Laboratory examination revealed a blood eosinophil count of 7536/µl. The patient was diagnosed with NEAE and a 7-day course of prednisolone (15 mg/day) was initiated, with rapid improvement in the oedema and no recurrence on follow-up. Discussion: The exact aetiology of NEAE is unknown, but it may develop after infection or drug exposure. Eosinophilic disease after COVID-19 infection has been reported and, therefore, eosinophilic angioedema should be considered in the differential diagnosis of non-pitting oedema of the extremities after a COVID-19 infection. Early diagnosis of NEAE is important as rapid improvement can be achieved with low-dose steroid treatment. Conclusion: NEAE can develop after COVID-19 and should be considered in the differential diagnosis of non-pitting oedema of the extremities.