bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the “performing-organizing” paradox: tensions between supply chain transparency, coordination, and scope 3 GHG emissions performance
Authors: Dahlmann Frederik , Brammer Stephen , Roehrich Jens K. 
Published: July 2023

PurposeDrawing on paradox theory and the category of the “performing-organizing” paradox, the study investigates the tensions firms experience in the context of organizing the processes involved in managing their indirect GHG emissions.Design/methodology/approachThe authors develop hypotheses to explain why the paradox elements of supply chain transparency and supply chain coordination affect firms' ability to reduce their indirect supply chains GHG emissions. Using a two-stage method based on data from Refinitiv and CDP for 2002 to 2021, the authors test this study’s hypotheses through panel regression analyses.FindingsWhile greater transparency experience with scope 3 emissions disclosure, GSCM practices and broader supply chain engagement are all associated with higher levels of scope 3 emissions levels, both long-term transparency experience and GSCM practices are also associated with relative reductions in scope 3 emissions over time.Practical implicationsGiven growing pressures on firms to demonstrate both transparency and legitimacy regarding their scope 3 emissions, firms must understand the characteristics of this paradox as this has implications for how emissions performance is perceived and managed. This study's results suggested that firms need to take both a long-term perspective and effectively communicate the differences involved in reporting their emissions performance to avoid unwarranted criticism.Originality/valueFilling a gap in sustainable OSCM studies by providing large-scale quantitative insights into the relationships between organizing and performing, the authors demonstrate that the processes involved in firms' efforts of measuring and managing their indirect scope 3 emissions are paradoxically affected by whether performance outcomes are specified as annual absolute levels of scope 3 emissions, or relative changes over time.
Knock‐out of multidrug efflux pump MexXY‐OprM results in increased susceptibility to antimicrobial peptides in Pseudomonas aeruginosa
Authors: Neidig Anke , Strempel Nikola , Waeber Nadine Bianca , Nizer Waleska Stephanie da Cruz , Overhage Joerg 
Published: July 2023

AbstractMultidrug efflux systems of the resistance‐nodulation‐cell division family play a crucial role in resistance of Pseudomonas aeruginosa to a large variety of antibiotics. Here, we investigated the role of clinically relevant efflux pumps MexAB−OprM, MexCD−OprJ, and MexXY−OprM in resistance against different cationic antimicrobial peptides (AMPs). Our results indicate that a knock‐out in efflux pump MexXY‐OprM increased susceptibility to some AMPs by two‐ to eightfold. Our data suggest a contribution of MexXY‐OprM in resistance to certain AMPs in P. aeruginosa, which should be considered in the future development of new and highly active antimicrobial peptides to fight multidrug resistant infections.
The study of the effect of HLA‐B27 on THP‐1 monocytic cells survival and its mechanism
Authors: Gui Lian , Gu Jieruo 
Published: July 2023

AbstractObjectivePrevious studies have shown that human leukocyte antigen (HLA)‐B27 induces the accumulation of unfolded proteins in the endoplasmic reticulum (ER) to cause ER stress, resulting in the unfold protein response (UPR), apoptosis and autophagy. However, it is still unknown whether it affects the survival of monocytes. In this study, we attempted to examine the effect of HLA‐B27 gene knockout on the proliferation and apoptosis of THP‐1 monocytic cell line and its potential mechanism.MethodsHLA‐B27 gene knockout THP‐1 cell line was constructed by lentivirus infection, and knockout efficiency was detected by immunofluorescence, quantitative reverse transcription ‐ polymerase chain reaction (qRT‐PCR) and western blot. Cell Counting Kit‐8 (CCK‐8) method and Annexin‐V/PI double staining were used to detect the proliferation and apoptosis of the constructed THP‐1 cell line, respectively. qRT‐PCR was used to detect the effect of HLA‐B27 inhibition on the expressions of ER molecular chaperone binding immunoglobulin protein (BiP) and genes about the UPR pathway. The proliferation rate of human BiP protein‐stimulated THP‐1 cells was detected by CCK‐8 method.ResultsHLA‐B27 gene knockout THP‐1 cells were successfully constructed by lentivirus infection. Knockout of HLA‐B27 effectively promoted the proliferation of THP‐1 cells and inhibited the apoptosis induced by cisplatin. qRT‐PCR showed that BiP was synchronously increased, while activation of UPR pathway was inhibited. Stimulation with human BiP promoted the proliferation of THP‐1 cells in a concentration‐dependent manner.ConclusionsHLA‐B27 inhibition can promote the proliferation and inhibit the apoptosis of THP‐1 cells. The inhibition function may be achieved through promotion of BiP and inhibition of UPR pathway activation.
The trauma experiences of children with fetal alcohol spectrum disorders: Developmental outcomes utilizing a threat/deprivation child adversity framework
Authors: Rockhold Madeline N. , Kautz‐Turnbull Carson , Handley Elizabeth D. , Petrenko Christie L. M. 
Published: July 2023

AbstractBackgroundIndividuals with fetal alcohol spectrum disorders (FASD) experience heightened rates of childhood trauma and adversity. Research has examined the negative impact adverse childhood experiences have on developmental outcomes. This study aims to take the field a step further by examining the details of traumatic events, including duration, perpetrator, whether the event significantly impacted the child, and trauma subtype. Subtype is examined using threat/deprivation dimensions and their relation to child behavior and the caregiver‐child relationship.MethodsA sample of 84 children aged 4–12 with FASD, all in out‐of‐home placements, and their families took part in an emotion coaching intervention study. At baseline, caregivers completed questionnaires assessing child trauma, child emotion regulation and behavior, caregiver emotion socialization, and caregiver‐child relationships. We used analysis of covariance to examine the differing impacts of threat, deprivation, and a combination of the two on behavioral outcomes, while controlling for age. We also used Pearson's r correlations, controlling for age, to examine whether the duration of threat or deprivation exposure was related to child outcomes.ResultsDescriptive statistics showed that 87.5% of individuals experienced three or more subtypes of trauma. The average duration of all subtypes was 1.62 years, with a mean onset of 3.94 years. Biological parents were the most common perpetrator. There were significantly worse behavioral and caregiver‐child relationship outcomes for children experiencing a combination of threat and deprivation trauma. Arcorrelations, controlling for age, demonstrated longer duration of deprivation was associated with greater cognitive difficulties.ConclusionsWe found unique patterns of behavior in children with FASD when analyzing the impact of traumatic experiences through a threat/deprivation framework. The combination of both threat and deprivation experiences leads to worse outcomes overall. Additionally, vital details surrounding the traumatic experiences point to crucial areas for intervention, including caregiver‐child relationships.
Indigo reduction by using microorganism: Comparison of reducing power between Dietzia sp. KDB1 and yeast (Saccharomyces cerevisiae)
Authors: Jung Chanhee , Rhee Jong Il , Shin Younsook , Yoo Dong Il 
Published: July 2023

AbstractThis study aims to develop microbial indigo reduction by comparing the reducing power between Dietzia sp. KDB1 and yeast (Saccharomyces cerevisiae) at some reduction conditions. Oxidation–reduction potential (ORP), colour strength (K/S), and fluorescence intensity (FI) were applied to evaluate the reduction level as a function of microorganism concentration, pH, and glucose addition at 30°C. For both of the microbial systems, ORP decreased further −20 mV and K/S increased more than two by adding glucose. The reduction level became higher slightly by adding glucose, which played a role of metabolite in both of the reduction systems. Overall, reduction level of the yeast system was about a half of KDB1 system at the same reduction condition of 45 mL volume, 15 g/L natural indigo, 6 g/L reducing agents, pH 10.0, 30°C and glucose added.
Education, Extremism, and Aversion to Compromise
Authors: Hand Michael 
Published: July 2023

AbstractSchools plausibly have a role to play in countering radicalization by taking steps to prevent the acquisition of extremist beliefs, dispositions, and attitudes. A core component of the extremist mindset is aversion to compromise. Michael Hand inquires here into the possibility, desirability, and means of educating against this attitude. He argues that aversion to compromise is demonstrably undesirable and readiness to compromise demonstrably desirable, so discursive teaching of these attitudes should guide pupils toward these verdicts. And he identifies three methods of formative teaching by which readiness to compromise can be cultivated in pupils.
Analysis of IL‐10 and IL‐35 in dipeptidyl peptidase‐4 inhibitor‐related bullous pemphigoid
Authors: Kokubu Hiraku , Takahashi Toshifumi , Kabuto Miho , Kouzaki Hideaki , Fujimoto Noriki 
Published: July 2023

AbstractThe association between immunoregulatory cytokines, such as interleukin (IL)‐10 or IL‐35, and dipeptidyl peptidase‐4 inhibitor (DPP4i)‐related bullous pemphigoid (BP) has not been evaluated. Serum IL‐10 and IL‐35 levels were measured in 39 patients with BP (24 males and 15 females; 6 DPP4i‐related and 33 DPP4i‐unrelated BP patients) and 10 healthy controls. The number of CD26+ cells in the dermis around bulla on sections was counted immunohistochemically for 12 patients (six patients with DPP4i‐related BP and six randomly sampled patients with DPP4i‐unrelated BP). Patients with DPP4i‐related BP had lower levels of serum eosinophils (DPP4i‐related vs. DPP4i‐unrelated BP: 476.1 ± 234.0 vs. 911.3 ± 948.8/μL; p = 0.537) and a higher rate of infiltrating CD26+ cells (32.9 ± 7.1% vs. 15.7 ± 4.4%; p = 0.01). There were no significant differences in serum IL‐10 (6.77 ± 0.24 vs. 6.84 ± 0.20 pg/mL), serum IL‐35 (2.63 ± 0.17 vs. 2.63 ± 0.21 pg/mL), serum anti‐BP180NC16a antibodies (67.31 ± 37.4 vs. 76.18 ± 54.59 U/mL) and Bullous Pemphigoid Disease Area Index before treatment in this study. Serum IL‐10 and IL‐35 levels do not increase in patients with BP and may not be a candidate for a therapeutic target for BP. An increase in CD26+ cells might be associated with DPP4i‐related BP.
Reproductive behavior of Atlantic halibut (Hippoglossus hippoglossus) interpreted from electronic tags
Authors: Marshall Rachel C. , Fisher Jonathan A. D. , Einfeldt Anthony L. , Gatti Paul , Robert Dominique , Le Bris Arnault 
Published: July 2023

AbstractReproductive timing, location, and behavior are important characteristics that determine marine population dynamics, structure, and resilience to threats, including fishing and climate change. It is challenging to evaluate factors driving variability in these reproductive traits in wild fishes because of the difficulty observing individuals in their natural environments. In the present study, we used high‐resolution depth, temperature, and acceleration time series recorded by pop‐up satellite archival tags to (1) identify and characterize patterns in depth and acceleration that may be indicative of spawning events in large Atlantic halibut (Hippoglossus hippoglossus), and (2) estimate the effects of individual traits (body size and sex) and environmental factors (location and temperature) on spawning time and frequency. Unique rapid rises observed in the winter depth profiles were interpreted as spawning events. The initiation of the first presumed spawning rise was negatively correlated to water temperature experienced during the prespawning season, suggesting that currently increasing water temperature in the Gulf of St. Lawrence may induce phenological change in halibut spawning time. The number of rises of batch‐spawning females was unrelated to female body size. The present study demonstrates how electronic tagging can be used for in‐depth characterization of timing, location, and behaviors associated with spawning in a large flatfish species. Such information can inform spatiotemporal management and conservation measures aiming to protect species from directed fishing and by‐catch during spawning.
Sharing Baraka in an Unexpected Place: The Emergence of Ziyāra Culture Among Sufi and ‘Alawi Muslims in Argentina1
Authors: Montenegro Silvia 
Published: July 2023

AbstractIn Argentina some branches of Islam have their own ziyāra circuits, building a local diasporic shrine culture. This paper examines sacred geographies created by ‘Alawis descendants of Syrian immigrants, who arrived in the early decades of the twentieth century, and Naqshbandi‐Haqqani sufis, Muslims who have converted from a Christian background. Based on ethnographic fieldwork conducted in Sufi and ‘Alawi communities, in Shaykh Ahmed Merhej's shrine and in the Naqshbandiyya‐Haqqaniyya dergāhs where there are maqāms ‐ cenotaphs erected in honor of Shaykh ‘Abdullah Daghestani‐ this article analyzes the configuration of two shrine cultures and their recent contact, showing the local rooting of a global practice among Muslims.
Neutrophil reactive oxygen formation, bacterial infections and mortality in malnourished hemodialysis patients: Evaluation of clinical outcomes
Authors: Mudrik‐Zohar Hadar , Alon Danny , Nacasch Naomi , Sternschuss Aviad , Greenberg Meidad , Benchetrit Sydney , Gavrieli Ronit , Zitman‐Gal Tali , Cohen‐Hagai Keren 
Published: July 2023

AbstractIntroductionPatients with end stage kidney disease undergoing maintenance hemodialysis (MHD) are prone to malnutrition and infections.ObjectiveThe objective of this study was to evaluate the effect of polymorphonuclear (PMN) cell dysfunction on clinical outcomes of MHD patients, in association with nutritional status.MethodsThis prospective study investigated 39 MHD patients by evaluating the oxidative activity of their PMN cells using Phorbol 12‐Myristate‐13‐Acetate (PMA) stimulation. Blood samples were taken from each participant at dialysis initiation. Demographics, laboratory data, and clinical outcomes during a 24‐month follow‐up period were obtained from electronic medical records.ResultsPhagocytic activity was described in percentiles of mean fluorescence intensity (MFI) of PMA levels. There were no differences in comorbidities between patients with low or high MFI‐PMA percentiles. Patients in the lowest (25th) MFI‐PMA percentile (N = 10) had poorer nutritional status and more frequent severe infections compared to the other 29 patients (4.3 ± 3.4 events versus 2 ± 2.2 events, p = 0.017). Furthermore, they had more frequent hospitalizations (>3) due to infections (70% versus 41%, p = 0.073) and their mortality rate was higher (80% versus 31%, p = 0.007). The odds ratio for all‐cause mortality was 8.85. In multivariate analysis, the MFI‐PMA percentile and ischemic heart disease were the strongest predictors of all‐cause mortality (p = 0.02 and p = 0.005, respectively).ConclusionsLow MFI‐PMA levels were associated with poor nutritional status and adverse clinical outcomes and might serve as a prognostic biomarker, predicting severe infections and mortality among malnourished MHD patients.
Single‐port laparoscopic‐assisted abdominal cryptorchidectomy in 14 dogs
Authors: David Sieglinde , de Rooster Hilde , Van Goethem Bart 
Published: July 2023

AbstractObjectiveTo describe a modified laparoscopic‐assisted cryptorchidectomy technique in dogs using a single‐port endoscope and evaluate clinical outcome in abdominal cryptorchid dogs that underwent the procedure.Study designProspective case series.AnimalsA total of 14 client‐owned dogs (19 abdominal cryptorchid testes).MethodsDogs scheduled for laparoscopic cryptorchidectomy between January 2019 and April 2022 were enrolled in the study. The dogs underwent single‐port laparoscopic‐assisted cryptorchidectomy (SP‐LAC) performed by a single surgeon using a 10‐mm single‐port endoscope placed in the midline immediately cranial to the prepuce. The abdominal testis was endoscopically located and grasped, the cannula was retracted, the capnoperitoneum was reversed to allow exteriorization of the testis, and the spermatic cord was ligated extracorporeally.ResultsMedian age was 13 months (range, 7–29 months) and median bodyweight was 23.0 kg (range, 2.2–55.0 kg). Nine of 14 dogs had unilateral abdominal cryptorchidism (7 right‐sided and 2 left‐sided) and 5/14 dogs had bilateral abdominal cryptorchidism. Median surgical time for unilateral abdominal cryptorchidectomy was 17 min (range, 14–21 min) and for bilateral abdominal cryptorchidectomy 27 min (range, 23–55 min). Ten dogs had additional surgical procedures performed concurrently with SP‐LAC. One major intraoperative complication (testicular artery hemorrhage) occurred that required emergency conversion and two minor entry‐related complications were observed.ConclusionThe SP‐LAC procedure enabled removal of abdominal testes and was associated with a low morbidity.Clinical significanceThe SP‐LAC procedure can be performed by a single surgeon and represents a less invasive alternative to multi‐port laparoscopic‐assisted or single‐port multi‐access laparoscopic cryptorchidectomy techniques.
Exploring barriers to and facilitators of malaria prevention practices: a photovoice study with rural communities at risk to Plasmodium knowlesi malaria in Sabah, Malaysia
Authors: Naserrudin Nurul Athirah , Lin Pauline Yong Pau , Monroe April , Culleton Richard , Baumann Sara Elizabeth , Sato Shigeharu , Adhikari Bipin , Fornace Kimberly M. , Hod Rozita , Jeffree Mohammad Saffree , Ahmed Kamruddin , Hassan Mohd Rohaizat 
Published: July 2023

Abstract
Background
The control of Plasmodium knowlesi malaria remains challenging due to the presence of macaque monkeys and predominantly outdoor-biting Anopheles mosquitoes around human settlements. This study aims to explore the barriers and facilitators related to prevention of mosquito bites among rural communities living in Sabah, Malaysia using the participatory visual method, photovoice.

Methods
From January through June 2022, 26 participants were recruited from four villages in Kudat, Sabah, using purposive sampling. Participants were male and female villagers, aged > 18 years old. After photovoice training in the villages, participants documented facilitators of and barriers related to avoiding mosquito bites using their own smartphone cameras, and provided narratives for their photos. Twelve Focus Group Discussions (FGDs) sessions in three rounds were held to share and discuss the photos, and to address challenges to the avoidance of mosquito bites. All discussions were conducted in the Sabah Malay dialect, and were video and audio recorded, transcribed, and analyzed using reflexive thematic analysis. The Ideation Model, a meta-theoretical model of behaviour change, underpinned this study.

Results
The most common types of barriers identified by participants included (I) intrapersonal factors such as low perceived threat of malaria, (II) livelihood and lifestyle activities consisting of the local economy and socio-cultural activities, and (III) physical and social environment. The facilitators were categorized into (I) intrapersonal reasons, including having the opportunity to stay indoors, especially women who are housewives, (II) social support by the households, neaighbours and healthcare workers, and (III) support from healthcare services and malaria awareness program. Participants emphasized the importance of stakeholder's support in implementing feasible and affordable approaches to P. knowlesi malaria control.

Conclusion
Results provided insights regarding the challenges to preventing P. knowlesi malaria in rural Kudat, Sabah. The participation of communities in research was valuable in expanding knowledge of local challenges and highlighting possible ways to overcome barriers. These findings may be used to improve strategies for zoonotic malaria control, which is critical for advancing social change and minimizing health disparities in malaria prevention.
Breast cancer and breast cancer screening use—beliefs and behaviours in a nationwide study in Malaysia
Authors: Tan Min Min , Jamil Aminatul Saadiah Abdul , Ismail Roshidi , Donnelly Michael , Su Tin Tin 
Published: July 2023

Abstract
Background
Many upper-middle-income countries (UMICs), including Malaysia, continue to face low breast cancer (BC) screening rates and patients with delayed presentation of BC. This study investigated the role of beliefs about BC and use of screening (e.g. beliefs about whether or not screening reduced the possibility of dying from BC).

Methods
A nationwide cross-sectional study was conducted in which a total of 813 women (aged ≥ 40 years old) were randomly selected and surveyed using the validated Awareness and Beliefs about Cancer (ABC) measure. The association between BC screening use, sociodemographic characteristics, and negative beliefs about BC screening were analysed using stepwise Poisson regressions.

Results
Seven out of ten Malaysian women believed that BC screening was necessary only when experiencing cancer symptoms. Women > 50 years and from households with more than one car or motorcycle were 1.6 times more likely to attend a mammogram or a clinical breast examination (mammogram: Prevalence Ratio (PR) = 1.60, 95% Confidence Interval (CI) = 1.19–2.14, Clinical Breast Examination (CBE): PR = 1.61, 95% CI = 1.29–1.99). About 23% of women expected to feel anxious about attending BC screening, leading them to avoid the procedure. Women who held negative beliefs about BC screening were 37% less likely to attend a mammogram (PR = 0.63, 95% CI = 0.42–0.94) and 24% less likely to seek a CBE (PR = 0.75, 95% CI = 0.60–0.95).

Conclusions
Public health strategies or behaviour interventions targeting negative beliefs about BC screening among Malaysian women may increase uptake and reduce late presentation and advanced-stage cancer. Insights from the study suggest that women under 50 years, in the lower income group without a car or motorcycle ownership, and of Malay or Indian ethnicity (compared to Chinese-Malay) are more likely to hold beliefs inhibiting BC screening.