bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into the Riemann Zeta Function
Authors: Arwashan Naji 
Published: February 2023

Abstract
In this paper we focus our attention on the zeta series ζ (s) = Σ∞n=1 1/ns in the domain of 0 < σ < 1 Even though the series is divergent in that domain, but we will find that its divergence will satisfy an asymptotic equation that involves the values of the zeta function in that same domain. Applying that equation to the critical line will lead us to a function that calculates the value of a convergent series of cosine waves; and interestingly we will find that the finite sum of that series is a combined wave that reorganizes the location of the nontrivial zeros of the Riemann zeta function on the critical line.
MSC code 11E45
Activation of Ca transport in cardiac microsomes enriches functional sets of ER and SR proteins
Authors: Cala Steven E. , Carruthers Nicholas J. , Stemmer Paul M. , Chen Zhenhui , Chen Xuequn 
Published: February 2023

Abstract
The importance of sarcoplasmic reticulum (SR) Ca-handling in heart has led to detailed understanding of Ca-release and re-uptake protein complexes, while less is known about other endoplasmic reticulum (ER) functions in the heart. To more fully understand cardiac SR and ER functions, we analyzed cardiac microsomes based on their increased density through the actions of the SR Ca-ATPase (SERCA) and the ryanodine receptor that are highly active in cardiomyocytes. Crude cardiac microsomal vesicles loaded with Ca oxalate produced two higher density subfractions, MedSR and HighSR. Analyses of protein enrichments from the 3 membrane preparations (crude microsomes, MedSR, and HighSR), showed that only a third of microsomal proteins in heart, or 354 proteins, were enriched ≥2.0-fold in SR. Previously studied SR proteins were all enriched, as were proteins associated with canonical ER functions. Contractile, mitochondrial, and sarcolemmal proteins were not enriched. Comparing the levels of SERCA-positive SR proteins in MedSR versus HighSR vesicles produced a range of SR subfraction enrichments signifying differing levels of Ca leak (ryanodine receptor) co-localized in the same membrane patch. All known junctional SR proteins were more enriched in MedSR, while canonical ER proteins were more enriched in HighSR membrane. Proteins from other putative ER/SR subdomains also showed characteristic distributions among SR subpopulations. We conclude that active Ca loading of cardiac microsomes, reflecting the combined activities of Ca uptake by SERCA, and Ca leak by RyR, permits evaluation of multiple functional ER/SR subdomains. Sets of proteins from these subdomains exhibited similar enrichment patterns across membrane subfractions, reflecting the relative levels of SERCA and RyR present within individual patches of cardiac ER and SR.
Synthesis and antimicrobial/antioxidant evaluation of novel pyrimidine-based derivatives with pendant pyrazoles using vinamidinum salts
Authors: Maghamifar Roya , Sheikhi-Mohammareh Seddigheh , Shiri Ali , Beyzaei Hamid , Ebrahimnezhad Zahra 
Published: February 2023

Abstract
Synthesis of a variety of 5-bromo-4-methyl-2-substituted pyrimidines endowed with pyrazolyl appended in C4 position is described via treatment of 5-bromo-4-hydrazineyl-6-methyl-2-substituted pyrimidines (6a–f) and vinamidinum salt of (E)-N-(3-(dimethylamino)-2-phenylallylidene)-N-methylmethanaminium perchlorate (5) in good to excellent yields. The inhibitory and hydrogen-atom donating abilities of the synthesized products were assessed against nine pathogens including six bacterial strains (both Gram-negative and Gram-positive), three fungal strains and DPPH free radicals. Notable antioxidant properties were not observed with the products. The inhibition zone diameters were determined in the range of 10.51–18.44 mm via Kirby-Bauer disk diffusion method. 5-Bromo-4-methyl-6-pyrazolylpyrimidine (7e) containing 2-(4-methylpiperazin) substituent showed the best antioxidant and antimicrobial effects. It was effective on all the tested microbial strains except Staphylococcus epidermidis. All the synthesized pyrazolyl pyrimidines, especially (7e) can be used to disinfect the environment and treat infectious diseases.
A comprehensive dynamic source model of shallow very low-frequency earthquakes
Authors: Wei Xueting , Liu Yuxiang , Xu Jiankuan , Chen Xiaofei 
Published: February 2023

Abstract
Very low-frequency earthquakes, which exhibit longer source durations and smaller stress drops than regular earthquakes of similar magnitude, possess abundant low-frequency energy but are depleted in high-frequency energy. The source processes that govern the occurrence of very low-frequency earthquakes remain unclear. Here, we implement a unified dynamic source model to illustrate the source characteristics of very low-frequency earthquakes. By comparing the source parameters of observed shallow very low-frequency earthquakes with those of numerically simulated ruptures, we conclude that very low-frequency earthquakes are slow self-arresting earthquakes that self-terminate within the nucleation patch. In addition, a composite slow self-arresting model is adopted to reproduce the source processes of VLF and LFE in Nankai area. Comparison of synthetic seismograms obtained from the composite model with the Nankai VLFs shows that slow self-arresting ruptures have the potential to explain different types of slow earthquakes. Our results indicate that very low-frequency earthquakes, low-frequency earthquakes and regular earthquakes can be explained uniformly in the same dynamic rupture phase diagram.
An optimized resource scheduling algorithm based on GA and ACO algorithm
Authors: Yin Chao , Li Hongyi , Peng Yingjian , Fang Qin , Xu Xiaogang , Dan Tang 
Published: February 2023

Abstract
With the development of Internet of things (IoT) technology, fog computing has gradually come into people’s vision because of the characteristics of real-time and low delay. Providing computing and storage services at the edge of the network, fog computing can meet the needs of users in delay-sensitive applications as a highly virtualized platform. Resource scheduling plays an important role in fog computing, because it can meet the requirements of customers and improve the quality of service. However, if largescale service requests can not solve the resource scheduling problem effectively, it will reduce resource utilization and user satisfaction. Focus on the above problem, we establish a resource scheduling model named normalization processing, which can achieve the goal of the lowest total cost by finding the optimal pheromone. The optimal resource scheduling results can be obtained by changing the pheromone concentration of ants during the simulated foraging process. At the same time, we propose a new resource scheduling algorithm named new genetic ant colony optimization (NGACO) algorithm, which can update pheromone generation by roulette algorithm. The experimental results show that the resource scheduling performance of NGACO algorithm is 14.7%, 25%, 12.8% lower than that of ACO algorithm in makespan, economic cost, total cost respectively, and load balancing is 34.7% higher than ACO algorithm.
Role of mir-554 and mir-313 in Trigger and Develop Non-small Cell Lung Cancer
Authors: Afshinpour Maral , Salimi Alireza , Salarinia Reza 
Published: February 2023

Abstract
Background: Lung cancer is known as one of the most common cancers worldwide. Non-small cell lung cancer (NSCLC) is found in 85% of cases of lung cancer. In this study, we tried to identify genes that can be used to prevent cancer from progressing by inhibiting their expression by microRNAs. These genes can be targeted as a treatment.
Objectives: identifing the dysregulated genes in lung adenocarcinoma based on gene expression profiles of LUAD and non-tumor lung.
Method: In this study, using the data obtained from the article, 37 genes were finally reached with the Venny 2.1 database. We then analyzed the genes involved in lung cancer, using databases such as DAVID, PANTHER, and ENRICHER.
Results: Our work provides insight into PDGFRA, LAMC1, and MAP3K8 have critical roles in important pathways and biological processes which can develop cancer such as; angiogenesis, integrin signaling pathway, and development process. for the first time, mir-554 and mir-313 plays a critical role by inhibiting the proto- oncogene genes map3k8, PDGFR and lamc1.
Wavelet-based de-noising in groundwater quality and quantity prediction by an artificial neural network
Authors: Vousoughi Farnaz Daneshvar 
Published: February 2023

Abstract
The present study uses a wavelet-based clustering technique to identify spatially homogeneous clusters of groundwater quantity and quality data and to select the most effective input data for the feed-forward neural network (FFNN) model to predict the groundwater level (GL), pH and HCO3− in groundwater. In the second stage of this methodology, first, GL, pH and HCO3− time series of different piezometers were de-noised using a threshold-based wavelet method and the impact of de-noised and noisy data were compared in temporal GL, pH and HCO3− modeling by the artificial neural network (ANN). The results suggest that the proposed model decreases the dimensionality of the input layer and consequently the complexity of the FFNN model with acceptable efficiency in the spatiotemporal simulation of GL and groundwater quality parameters. Also, the application of wavelet-based de-noising for modeling GL, pH and HCO3− parameters with ANN increases the accuracy of predictions, respectively, up to 11.53, 11.94 and 38.85% on average.
Photocatalytic treatment of organoselenium in synthetic mine-impacted effluents
Authors: Martin Jeffrey Thomas , Chai Tia , Leshuk Timothy Michael Carter , Young Zachary William , Gu Frank 
Published: February 2023

ABSTRACT

Biological selenium reduction processes are commonly employed as the best available technology (BAT) for selenium removal; however, as a by-product they produce trace amounts of organoselenium compounds with orders of magnitude greater bioaccumulation potential and toxicity. Here, we assessed buoyant photocatalysts (BPCs) as a potential passive advanced oxidation process (P-AOP) for organoselenium treatment. Using a synthetic mine-impacted water solution, spiked with selenomethionine (96 μg/L) as a representative organoselenium compound, photocatalysis with BPCs fully eliminated selenomethionine to &lt;0.01 μg/L with conversion to selenite and selenate. A theoretical reaction pathway was inferred, and a kinetics model developed to describe the treatment trends and intermediates. Given the known toxic responses of Lepomis macrochirus and Daphnia magna to organoselenium, it was estimated that photocatalysis could effectively eliminate organoselenium acute toxicity within a UV dose of 8 kJ/L (1–2 days solar equivalent exposure), by transformation of selenomethionine to less hazardous oxidized Se species. Solar photocatalysis may therefore be a promising passive treatment technology for selenium-impacted mine water management.
A Review on Shikonin and its Derivatives as Potent Anticancer
Agents Targeted against Topoisomerases
Authors: Olatunde Olagoke Zacchaeus , Yong Jianping , Lu Canzhong , Ming Yanlin 
Published: February 2023

Abstract:
The topoisomerases (TOPO) play indispensable roles in DNA metabolism, by
regulating the topological state of DNA. Topoisomerase I and II are the well-established
drug-targets for the development of anticancer agents and antibiotics. These drugs-targeting
enzymes have been used to establish the relationship between drug-stimulated DNA
cleavable complex formation and cytotoxicity. Some anticancer drugs (such as camptothecin,
anthracyclines, mitoxantrone) are also widely used as Topo I and Topo II inhibitors,
but the poor water solubility, myeloma suppression, dose-dependent cardiotoxicity,
and multidrug resistance (MDR) limited their prolong use as therapeutics. Also, most of
these agents displayed selective inhibition only against Topo I or II. In recent years, researchers
focus on the design and synthesis of the dual Topo I and II inhibitors, or the discovery
of the dual Topo I and II inhibitors from natural products. Shikonin (a natural
compound with anthraquinone skeleton, isolated from the roots of Lithospermum erythrorhizon)
has drawn much attention due to its wide spectrum of anticancer activities, especially
due to its dual Topo inhibitive performance, and without the adverse side effects,
and different kinds of shikonin derivatives have been synthesized as TOPO inhibitors
for the development of anticancer agents. In this review, the progress of the shikonin
and its derivatives together with their anticancer activities, anticancer mechanism, and
their structure-activity relationship (SAR) was comprehensively summarized by searching
the CNKI, PubMed, Web of Science, Scopus, and Google Scholar databases.
New Concepts in the Manipulation of the Aging Process
Authors: Hollands Peter , Ovokaitys Todd 
Published: February 2023

Abstract:
This review explores the current concepts in aging and then goes on to describe a novel,
ground-breaking technology which will change the way we think about and manage aging. The foundation
of the review is based on the work carried out on the QiLaser activation of human Very Small Embryonic
Like (hVSEL) pluripotent stem cells in autologous Platelet Rich Plasma (PRP), known as the
Qigeneration Procedure. The application of this technology in anti-aging technology is discussed with an
emphasis on epigenetic changes during aging focusing on DNA methylation.
Measuring family functioning: validation and adaptation of the family APGAR into Indonesian
Authors: Ridwan Edi Sampurno , Sarwadhamana Raden Jaka , Rofiyati Winda 
Published: February 2023

<p><strong><em>Background</em></strong><em>: Family function is an important part of family caring particularly for those with aged people in the household. Understanding family functioning is imperative. A valid and reliable tool for measuring the family functioning of Indonesian family caregivers is limited. </em></p><p><strong><em>Objectives:</em></strong><em> This study aimed to examine cross-cultural adaptation, validity, and reliability of the Indonesian version of the family APGAR. </em></p><p><strong><em>Methods:</em></strong><em> A cross-sectional design was performed as a part of a study measuring subjective family readiness for long-term care at home. A total of 125 family caregivers who were caring for older family members completed face-to-face interviews. A five-items of the family APGAR were translated, validated, and tested its reliability using standardized methods. The correlation matrix was performed to identify item correlations prior to the validation process. Hypothesis testing used a significance value of P = &lt; 0.05 with a confidence interval (CI = 95%). The statistical test was performed using STATA14 statistical software.</em></p><p><strong><em>Results:</em></strong><em> In 125 respondents with a mean age of 52.60 years (CI = 12. 29) were interviewed. The respondents were mostly female 84 (62.20%), employed (85/68.00%). Item test correlation was ranging from 0.77 to 0.90 and the average item correlation was 0.61. Pearson coefficients were presented. The coefficient of scale reliability was Cronbach alpha 0.89.</em></p><p><strong><em>Conclusions:</em></strong><em> The Indonesian version of the family APGAR was a valid and reliable tool used for measuring family functioning among Indonesian. Further study on the use of the instrument in different settings and community characteristics was suggested using categorical level from previously measured. </em></p>
Leading-Digit Patterns from Smart Water Meters
Authors: Sowby Robert B. , Jones Daniel R. 
Published: February 2023

As infrastructure develops and adoption of smart water meters increases,
new techniques are needed to validate and learn from the large datasets
they produce. Patterns of leading digits (i.e., first non-zero digits, 1
through 9) can support this task. This study examines leading digits in
hourly smart meter readings from a western U.S. water utility with over
5,000 customer connections. Benford analysis, power law analysis, and
leading-digit-frequency analysis all indicate that the readings tend
toward values that start with 1. The findings suggest that readings from
smart water meters - and, by extension, water use by individual
customers - could be expected to follow a particular nonuniform pattern
of leading digits and that deviation from the pattern may indicate data
errors or abnormal water use. Applications are suggested for validating
water use data, comparing multiple datasets, checking projections, and
assessing meter performance. Additional work is needed to further
explore the beneficial uses of leading-digit patterns and other data
signatures in water use data from diverse datasets.
Molecular Characterization of Plant Growth Promoting Pseudomonas from Rhizosphere of Euphorbia caducifolia Haines
Authors:   Dept. of Microbiology, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar (385 506), Gujarat, India, Joshi Bhavesh M. , Patel Mrugesh M. ,   Dept. of Microbiology, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar (385 506), Gujarat, India, Parmar Rudra B. ,   Dept. of Microbiology, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar (385 506), Gujarat, India, Singh N. K. ,   Dept. of Microbiology, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar (385 506), Gujarat, India, Tapre P. V. ,   Dept. of Microbiology, Chimanbhai Patel College of Agriculture, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar (385 506), Gujarat, India
Published: February 2023

A study was conducted during kharif 2020 at the Department of Microbiology, Chimanbhai Patel College of Agriculture, S. D. Agricultural University for molecular characterization of plant growth promoting Pseudomonas isolates from rhizosphere of Euphorbia caducifolia. Twenty Pseudomonas isolates (designated as PsEc1 to PsEc20) were axenically isolated from rhizospheric soil sample of Euphorbia caducifolia using Pseudomonas Isolation Agar Base (a selective medium). These isolates were tested gram negative, rod shaped, and oxidase positive. All 20 isolates were positive for utilization of maltose, esculin, citrate and malonate whereas these isolates showed varied results for utilization of xylose, fructose, galactose, sucrose and sorbitol. 16Sr DNA sequencing data revealed similarity of the isolates to different species of Pseudomonas, i.e., P. fluroscens (11), P. aeruginosa (3), P. putida (3), P. stutzeri (2) and P. syringe (1). These nucleotide sequences were submitted to the NCBI GenBank database with accession numbers respectively MT775484 to MT775503. The 16S rDNA sequences were aligned and used to reconstruct a phylogenetic tree with bootstrap values using software MEGA 6.06. The phylogenetic tree comprised of three clades. Clade I comprised of sixteen isolates, clade II four isolates and clade III only one isolate. The members of clade I belonged to P. fluorescens, P. putida and P. stutzeri whereas members of clade II comprised of P. aeruginosa. However, clade III consisted of P. syringae. In vitro test showed PsEc17 (P. fluorescens, MT775500) as most efficient in solubilizing tricalcium phosphate (78.53 µg ml-1) and IAA production (78.53 µg ml-1). PsEc17 also proved most efficient and showed 69.5% inhibition of Fusarium oxysporum f. sp. cumini.
IoT Based Integrated System to Monitor the Ideal Environment for Shrimp Cultivation with Android Mobile Application
Authors: Mahmud Hasan , Rahaman Md. Afzalur , Hazra Subrata , Ahmed Shariar 
Published: February 2023

Bangladeshi shrimp aquaculture has shown to be successful and efficient at earning foreign cash. The country covers 147570 square kilometers, 17% of which is roughly made up of coastal brackish water. Shrimp farming is thought to be more favorable in this larger coastal tide area, and 0.276 million hectares of land are being used for brackish water shrimp farming. The coastal area offers the best prospects for shrimp and prawn cultivation for two key reasons. The mangrove ecosystems' distinctive biodiversity is the first justification, and a shrimp-friendly habitat is the second. A large number of fishing vessels are sent out into the seas in order to mine shrimp which is undoubtedly considered a challenging job. Therefore, growing shrimp in tanks, especially in tropical regions, is more sensible for farmers. In this paper, we have developed an IoT-based solution that connects devices to collect data on shrimp farms, and sensing equipment and then sends it to a distant server to analyze and generate decisions. This smart farm offers real-time agriculture monitoring. The main components of the system are three embedded sensors to assess the temperature, turbidity, and light that impact the quality of the water. The system also incorporates of an android-based mobile application that facilitates farmers with remote monitoring capabilities to keep track of sensor readings, manage the shrimp production cycle, and check on the health of shrimp from different farms.
PEMBAGIAN HARTA BERSAMA ISTRI TURUT MENCARI NAFKAH PERSPEKTIF HUKUM ISLAM DAN HUKUM POSITIF DI INDONESIA
Authors: Efrinaldi Efrinaldi , Jayusman Jayusman , Hidayat Rahmat Hidayat , Bunyamin Mahmudin 
Published: February 2023

Kompilasi Hukum Islam pasal 97 menegaskan bahwa mantan istri atau mantan suami yang bercerai, masing-masing berhak mendapatkan seperdua dari harta bersama sepanjang tidak ditentukan lain dalam perjanjian perkawinan. Keduanya mendapatkan bagian yang sama dengan logika mereka telah menjalankan fungsi dan tugas yang setara; suami bertugas mencari nafkah dan istri mengurus rumah tangga. Hukum positif di Indonesia tidak membahas tentang pembagian harta bersama terkait istri turut sebagai pencari nafkah dalam keluarga. Sehingga ia dalam kondisi menanggung double bardon. Fokus penelitian ini adalah: pembagian harta bersama istri turut mencari nafkah menurut hukum Islam dan hukum positif di Indonesia? Kesimpulan penelitian ini bahwa permasalahan tentang harta bersama tidak diatur dalam perspektif Hukum Islam Tradisional tidak mengatur hal ini. Namun dalam Hukum Islam Kontemporer mengqiyaskannya dengan masalah Syirkah sedangkan yang lain menjustifikasinya berdasarkan urf dan maslahah. Adapun pembagiannya secara kesepakatan damai antara para pihak. Sedangkan dalam Hukum Positif diatur dan pembahagiannya masing-masing pihak mendapatkan setengah dari harta bersama.