bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe obstructive colitis treated with repeated colonoscopic decompression
Authors: Arai Junya , Suzuki Nobumi , Hayakawa Yoku , Matzuzaki Hiroyuki , Yokoyama Yuichiro , Aoki Tomonori , Ishibashi Rei , Odawara Nariaki , Ihara Sozaburo , Tsuji Yosuke , Ishihara Soichiro , Fujishiro Mitsuhiro 
Published: May 2023

AbstractObstructive colitis is an acute condition caused by colorectal strictures and requires a combination of therapeutic strategies, including surgery, endoscopic interventions, and medications. Here, we describe the case of a 69‐year‐old man who developed severe obstructive colitis owing to diverticular stenosis of the sigmoid colon. We immediately performed endoscopic decompression to avoid perforation. The mucosa of the dilated colon appeared black, suggesting severe ischemia. We considered surgical total colectomy owing to the extensive colitis. However, considering the invasiveness of the emergent surgery, we adopted a conservative approach as enhanced computed tomography demonstrated colonic dilation with maintained blood flow in the deeper layer of the colonic wall and no signs of colonic necrosis, such as peritoneal irritation sign or elevation of deviation enzymes, were observed. Moreover, the patient preferred a conservative approach, and surgeons in our team agreed with this conservative approach. While relapses of colonic dilation occurred several times, antibiotic treatment and repeated endoscopic decompression successfully suppressed the dilation and systemic inflammation. The colonic mucosa healed gradually, and we performed a colostomy without resecting a large portion of the colorectum. In conclusion, severe obstructive colitis with maintained blood flow can be treated with endoscopic decompression instead of emergent resection for a wide portion of the colorectum. Moreover, endoscopic images of improved colitic mucosa obtained through repeated colorectal procedures are rare and noteworthy.
DCM Support: cell therapy and circulatory support for dilated cardiomyopathy patients with severe ventricular impairment
Authors: Reid Alice , Hussain Mohsin , Veerapen Jessry , Ramaseshan Rohini , Hall Russell , Bowles Ruth , Jones Daniel A. , Mathur Anthony 
Published: May 2023

AbstractAimsThe DCM Support trial (NCT03572660) uses a percutaneous circulatory support device (Impella CP, Abiomed, Danvers, MA, USA) to improve the safety of an intracoronary cell infusion procedure in patients with dilated cardiomyopathy (DCM) and a severely reduced left ventricular ejection fraction (LVEF).Methods and resultsDCM Support is a single‐site, single‐arm Phase II trial enrolling 20 symptomatic DCM patients with an LVEF ≤ 35% despite optimal medical and device therapy. After 5 days of granulocyte colony‐stimulating factor therapy and a subsequent bone marrow aspiration, patients undergo an intracoronary infusion of autologous bone‐marrow‐derived mononuclear cells. The Impella CP device is used to provide haemodynamic support during the infusion procedure. The trial's primary endpoint is change in LVEF from baseline at 3 months. Secondary efficacy endpoints are change in LVEF from baseline at 12 months, and change in exercise capacity, New York Heart Association class, quality of life, and N‐terminal pro‐B‐type natriuretic peptide levels from baseline at 3 and 12 months. Safety endpoints include procedural safety and major adverse cardiac events at 3 and 12 months.ConclusionsThis is the first trial to assess the safety and efficacy of cytokine and autologous intracoronary cell therapy with a procedural circulatory support device for patients with severe left ventricular impairment. This novel combination may allow us to target a patient population most at need of this therapy.
A techno economic and environmental assessment of a hybrid waste tires‐renewable system for sustainable energy supply
Authors: Brahim Lotfi , Mosbah Mohamed Salah , Khila Zouhour , Hajjaji Noureddine 
Published: May 2023

AbstractThe rapid rise in industrial and human energy consumption has caused a significant increase in global energy demand. In order to meet simultaneously the increasing energy demand and protect the environment, researchers have put more effort into the development of new more sustainable energy sources.One of the promising alternatives for energy production in Pneumatic industrial sector is the integration of a hybrid power system, and making value to their produced waste and collected (tire waste) to use as an alternative energy sources. Considering the above‐mentioned facts, this study shows a techno‐economic and environmental assessment of a novel hybrid waste‐solar system configuration composed of an external depolymerization plant fueled by tires waste producing fuel for a co‐generator and a photovoltaic solar power plant ensuring the complement of the electrical need of our industrial.The novelty of this work is the development of the research methodology and innovative Solar/Waste hybrid power system from the existing system. The simulation is carried out in the HOMER software, the integrated system results in a Cost of Energy evaluated as 0.062 $/kWh, and 25.89% of avoided Greenhouse gasses emissions with an annual carbon credit of 32,422 $.
Review and Development of Best Practices for Toxicity Tests with Dreissenid Mussels
Authors: Waller Diane , Pucherelli Sherri , Barbour Matthew , Tank Samantha , Meulemans Matthew , Wise Jeremy , Dahlberg Angelique , Aldridge David C. , Claudi Renata , Cope W. Gregory , Gillis Patricia L. , Kashian Donna R. , Mayer Denise , Stockton-Fiti Kelly , Wong Wai Hing 
Published: May 2023

Abstract
Since their introduction to North America in the 1980s, research to develop effective control tools for invasive mussels (Dreissena polymorpha and D. rostriformis bugensis) has been ongoing across various research institutions using a range of testing methods. Inconsistencies in experimental methods and reporting present challenges for comparing data, repeating experiments, and applying results. The Invasive Mussel Collaborative established the Toxicity Testing Work Group (TTWG) in 2019 to identify “best practices” and guide development of a standard framework for dreissenid mussel toxicity testing protocols. We reviewed the literature related to laboratory-based dreissenid mussel toxicity tests and determined the degree to which standard guidelines have been used and their applicability to dreissenid mussel testing. We extracted detailed methodology from 99 studies from the peer-reviewed and gray literature and conducted a separate analysis for studies using presettlement and postsettlement mussels. We identified specific components of methods and approaches that could be refined or standardized for dreissenid mussels. These components included species identification, collection methods, size/age class distinction, maintenance practices, testing criteria, sample size, response measures, reporting parameters, exposure methods, and mortality criteria. We consulted experts in the field of aquatic toxicology and dreissenid mussel biology on our proposed. The final recommendations contained in the present review are based on published standard guidelines, methods reported in the published and gray literature, and the expertise of TTWG members and an external panel. In addition, our review identifies research needs for dreissenid mussel testing including improved methods for early–life stage testing, comparative data on life stages and between dreissenid mussel species, inclusion of a reference toxicant, and additional testing of nontarget species (i.e., other aquatic organisms). Environ Toxicol Chem 2023;42:1649–1666. © 2023 His Majesty the King in Right of Canada. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Reproduced with the permission of the Minister of Environment and Climate Change Canada. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Physicochemical characteristics, antioxidant potential, and shelf stability of developed roselle–fig fruit bar
Authors: Aslam Hunaina , Nadeem Muhammad , Shahid Urooj , Ranjha Muhammad Modassar Ali Nawaz , Khalid Waseem , Qureshi Tahir Mahmood , Nadeem Muhammad Ather , Asif Alaiha , Fatima Mehak , Rahim Muhammad Abdul , Awuchi Chinaza Godswill 
Published: May 2023

AbstractFruit bars are prepared by combining different ingredients which are wholesome and nutrient rich. The current study was designed to develop roselle–fig (different proportions) fruit bars and further investigate their physicochemical characteristics and antioxidant potential. Moreover, the prepared fruit bars were scrutinized for microbial and sensory characteristics to assess the appropriateness of ingredients during storage (up to 90 days). It was observed that there was gradual increase in moisture content with the passage of time, while ash, fat, fiber, and protein contents did not change significantly during storage. The pH and total soluble solid contents of these fruit bars during storage were 3.54–4.07 and 1.71–1.86 Brix, respectively. According to the mean values for sensory evaluation, T2 was preferred over other treatments. The bars received an acceptable sensory evaluation, demonstrating that they were suitable for 90 days of storage. Phytochemical quantities significantly increased in subsequent treatments, but decreased during storage in all the treatments. Similar trend was observed regarding total antioxidant and DPPH radical scavenging activities. The mineral contents increased significantly among the treatments. The microbial analysis of fruit bars exposed that the fruit were microbiologically safe. Hence, on the basis of the results obtained in this study, it may be concluded that the developed roselle–fig fruit bar would be acceptable and nutritious regarding physicochemical characteristics, microbiological quality, and antioxidant potential.
Follow‐Up Effect of Wechat Group on Discharged Patients with Colles Fracture
Authors: Tang Lifen , Dai Jingjing 
Published: May 2023

AbstractThis work explores the effect of a Wechat group on follow‐up and continuation of nursing for discharged patients with Colles fracture. A total of 96 patients with Colles fracture are enrolled and randomized into two groups by the random number table method. The control group is followed up and guided by traditional methods. Based on the follow‐up method adopted in the control group, a Wechat group is combined with Wechat constant tracking. The regular follow‐up rate, a satisfaction of with continuing care, Gartland–Werley wrist score, the exercise of self‐care agency score (ESCA score), and complications are compared and analyzed. The regular follow‐up rate, satisfaction, Gartland–Werley wrist score, and self‐care ability of patients in the Wechat group are significantly higher than those in the control group (p < 0.05). Statistical analysis of postoperative complications showed that although there is no significant difference in the incidence of median nerve irritation and incision infection (p > 0.05), the proportion of joint stiffness in the control group is significantly higher (p < 0.05). The establishment of Wechat groups to follow up and continue nursing for discharged patients with Colles fracture is helpful to achieve better clinical efficacy and improve the effective way for doctor–patient communication, which is worthy of active promotion.
Fluorescent Groups at the Core of Phosphorus Dendrons and Their Properties
Authors: Caminade Anne‐Marie , Hameau Aurélien , Moineau‐Chane Ching Kathleen , Turrin Cédric‐Olivier 
Published: May 2023

AbstractThis review presents the synthesis of dendrons (dendritic wedges) based on cyclotriphosphazene cores, in which one function is a fluorescent group, and the five remaining functions are used for growing the dendritic branches. The growing of the branches is carried out by a divergent method, using a two‐step process which implies hydroxybenzaldehyde and the phosphorhydrazide H2NNMeP(S)Cl2. Four different fluorophores have been used, derived from maleimide, julolidine, pyrene, or from a near‐infra‐red fluorophore. Depending on the type of fluorophore and on the type of terminal functions of the dendrons, different applications have been targeted. One can cite experiments in catalysis or for the elaboration of materials, transfection experiments, the study of anti‐cancer properties, and imaging in relation with the human immune system.
The power of academic and public opinion in conservation: The case of Ayyalon Cave, Israel
Authors: Gavish‐Regev Efrat , Frumkin Amos , Na'aman Israel , Langford Boaz , Aharon Shlomi , Ya'aran Shemesh , Kolodny Oren , Mammola Stefano 
Published: May 2023

AbstractWhile pessimism dominates discussions on biodiversity loss, it is increasingly recognized that for the long‐term success of conservation programs, we also need hope. One way to foster hope is to celebrate the positive outcomes of conservation efforts. Here, we report on a successful step in the conservation efforts of Ayyalon cave, a unique subterranean ecosystem discovered in 2006 as a result of mining activities in a quarry in central Israel. Ayyalon cave is one of the few known fully sustained subterranean autotrophic sulfur‐based food webs, in turn supporting a diverse, specialized endemic fauna. Upon the discovery of the cave, its isolation from the surface was compromised, resulting in colonization of alien species and changes in environmental conditions. In May 2021, the cave was put at additional risk following a plan to inject millions of cubic meters of fresh, cold, and oxidized water into the quarry. A team of Israeli scientists decided to take action, starting a highly mediatic campaign to save the cave. This campaign involved cooperation among domestic and foreign academics, the general public sector, and diverse stakeholders. Despite strong economic interests, the conservation campaign succeeded in pushing the National Infrastructure Committee to rectify the plan to inject water into the cave. Stemming from this success, we discuss important take‐home messages that are paramount for the broader conservation science community.
Effects of general change mechanisms on outcome in telephone‐based cognitive‐behavioral therapy for distressed family caregivers
Authors: Wrede Nicolas , Töpfer Nils F. , Wilz Gabriele 
Published: May 2023

AbstractBackgroundThe study investigated the influence of general change mechanisms (GCMs) on outcome in telephone‐based cognitive‐behavioral therapy (CBT) for family caregivers.MethodsIn a stepped‐care intervention approach, highly distressed family caregivers received telephone‐based CBT after completing a care counseling intervention. Sixty‐six therapist‐caregiver dyads rated emotional bond, agreement on collaboration, problem actuation, resource activation, clarification of meaning, and mastery after each of 12 therapy sessions. Outcomes were caregiver burden (SCQ‐AV) and depression (CES‐D) after therapy. Associations of GCMs with outcome were examined in multilevel regression models.ResultsCaregiver burden was significantly predicted by caregiver‐rated emotional bond (β = −0.18) as well as therapist‐rated resource activation (β = −0.26), problem actuation (β = −0.22), clarification of meaning (β = −0.18), and mastery (β = −0.18). None of the GCMs predicted depression from any perspective.ConclusionThe findings suggest that GCMs are relevant for reducing caregiver burden in CBT for family caregivers and should be fostered in treatment manuals, in particular therapist‐rated GCMs. Since therapist and caregiver perspectives differed in predicting caregiver burden, future research should investigate perspective congruence and its effect on therapy outcome.
Woodchips biochar versus bone char in a one‐year model soil incubation experiment: the importance of soil/char pH alteration on nutrient availability in soil
Authors: Száková Jiřina , Stiborová Hana , Mercl Filip , Hailegnaw Niguss Solomon , Lhotka Miloslav , Derevyankina Tatyana , Paul Chandra Sekhar , Taisheva Altyn , Brabec Marek , Tlustoš Pavel 
Published: May 2023

AbstractBACKGROUNDBiochars have become one of the most intensively and extensively investigated soil amendment materials in terms of their production, application and fate in the soil because of benefits such as increased soil quality and fertility. Biochar from woodchips and bone char from meat bone waste from a poultry slaughterhouse were prepared at 300 and 500 °C and then thoroughly mixed with two soils (cambisol and luvisol) that differed in their physicochemical parameters in ratios of 2% and 5% (w/w).RESULTSThe impact of bone and biochar amendments on nutrient availability was assessed during a one‐year model laboratory experiment. The feedstock origin and pyrolysis temperature affected the prepared materials’ physical properties and nutrient (Ca, Cu, K, Mg, Mn, P, S, Zn) availability. With increasing temperature, the structure of woodchip biochar changed from macroporous to microporous, and bone char changed from non‐porous to mesoporous. However, when mixed with soil, the biochar‐derived change in soil pH was revealed to be the most crucial parameter affecting soil nutrient mobility. Of all the tested elements, Only Cu, Fe and Zn were unaffected by biochar addition. Furthermore, temporal changes in element mobility during incubation were also elucidated.CONCLUSIONThe changes over time in element mobility indicated that soil properties were more important than bone and biochar characteristics. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).
Assessment of Myocardial Viability and Risk Stratification in Coronary Chronic Total Occlusion: A Qualitative and Quantitative Stress Cardiac MRI Study
Authors: Jiang Mengchun , Chen Yueqin , Su Yang , Guo Hu , Zhou Xiaoyue , Luo Meichen , Zeng Mu , Hu Xinqun 
Published: May 2023

BackgroundIndicators for assessing myocardial viability and risk stratification in patients with coronary chronic total occlusion (CTO) are still in the research stage.PurposeTo use stress‐MRI to assess myocardial function, blood perfusion, and viability and to explore their relationship with collateral circulation.Study TypeProspective.SubjectsFifty‐one patients with CTO in at least one major artery confirmed by X‐ray coronary angiography (male: 46; age 55.2 ± 10.8 years).Field Strength/Sequence3.0T; TurboFlash, balanced steady‐state free precession cine, and phase‐sensitive inversion recovery sequences.AssessmentStress‐MRI was used to obtain qualitative and quantitative parameters of segmental myocardium. Myocardial segments supplied by CTO target vessels were grouped according to the degree of collateral circulation assessed by radiographic coronary angiography (no/mild, moderate, or good). Depending on qualitative stress perfusion assessment and late gadolinium enhancement (LGE) extent, segments were also categorized as negative, viable, or trans‐infarcted.Statistical TestsIndependent sample Student's t‐test, one‐way analysis of variance (ANOVA) test, Mann–Whitney U test, Kruskal–Wallis test, Spearman correlation coefficient (r). P < 0.05 was considered statistically significant.ResultsA total of 334 segments were supplied by CTO target vessels. The radial strain (RS), circumferential strain (CS), longitudinal strain (LS) of the negative, viable, and trans‐infarcted regions showed a significant and stepwise impairment. Myocardial blood flow at rest was positively correlated with RS, CS, and LS (r = 0.42, 0.43, 0.38, respectively). Among the different collateral circulation, there were no significant differences in RS, CS, LS, and LGE volume (P = 0.788, 0.562, 0.122, 0.170, respectively), and there were also no statistically significant differences in the proportions of negative, viable, and trans‐infarcted regions (P = 0.372).Data ConclusionMyocardial perfusion obtained by stress‐MRI combined with strain and LGE may comprehensively evaluate myocardial function and viability, and has potential to facilitate risk stratification of CTO.Evidence Level2Technical EfficacyStage 1
The cellular redox state in Bacillus amyloliquefaciens WH1 affects biofilm formation indirectly in a surfactant direct manner
Authors: Sun Huiwan , Si Fengmei , Zhao Xiuyun , Li Feng , Qi Gaofu 
Published: May 2023

AbstractSurfactin is a signal to trigger biofilm formation against harsh environments. Generally, harsh environments can result in change of the cellular redox state to induce biofilm formation, but we know little about whether the cellular redox state influences biofilm formation via surfactin. Here, the reductant glucose could reduce surfactin and enhance biofilm formation by a surfactin‐indirect way. The oxidant H2O2 led to a decrease of surfactin accompanying with weakened biofilm formation. Spx and PerR were both necessary for surfactin production and biofilm formation. H2O2 improved surfactin production but inhibited biofilm formation by a surfactin‐indirect manner in Δspx, while it reduced surfactin production without obvious influence on biofilm formation in ΔperR. The ability against H2O2 stress was enhanced in Δspx, but weakened in ΔperR. Thereby, PerR was favorable for resisting oxidative stress, while Spx played a negative role in this action. Knockout and compensation of rex also supported that the cells could form biofilm by a surfactin‐indirect way. Collectively, surfactin is not a unique signal to trigger biofilm formation, and the cellular redox state can influence biofilm formation by a surfactin‐direct or ‐indirect way in Bacillus amyloliquefaciens WH1.
Biofilm formation in Gram‐positives as an answer to combined salt and metal stress
Authors: Harpke Marie , Kothe Erika 
Published: May 2023

AbstractBiofilm formation can lead to tolerance against stressors like antibiotics, toxic metals, salts, and other environmental contaminants. Halo‐ and metal‐tolerant bacilli and actinomycete strains isolated from a former uranium mining and milling site in Germany were shown to form biofilm in response to salt and metal treatment; specifically, Cs and Sr exposition led to biofilm formation. Since the strains were obtained from soil samples, a more structured environment was tested using expanded clay to provide porous structures resembling the natural environment. There, accumulation of Cs could be shown for Bacillus sp. SB53B, and high Sr accumulation ranging from 75% to 90% was seen with all isolates tested. We could, therefore, show that biofilms in a structured environment like soil will contribute to the water purification obtained by the passage of water through the critical zone of soil, providing an ecosystem benefit that can hardly be overestimated.