bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bibliometric analysis of global publication trends on rTMS and aphasia
Authors: Wang Taiwei , Huang Xuemiao , Zhao Lijing , Wang Yuan , Zhang Shuang , Fu Xiaochen , Zhang Tingyu , Jiang Junjie 
Published: May 2023

Background:
Aphasia is one of the most devastating cognitive disorders caused by brain injury and seriously hinders patients’ rehabilitation and quality of life. Repetitive transcranial magnetic stimulation involves the repeated application of extracranial pulsed magnetic fields to the local central nervous system to alter the membrane potential of cortical nerve cells, generating induced currents that affect brain metabolism and electrical activity. As one of the most popular noninvasive brain stimulation techniques, it has been used to treat aphasia. However, only a few bibliometric studies have examined the research direction and main findings in the field.

Methods:
To obtain an in-depth understanding of the research status and trend in this area, a bibliometric analysis based on the Web of Science database was conducted. VOSviewer (Leiden University, Leiden, Netherlands) and Microsoft Excel (Microsoft, Redmond, USA) were used to extract bibliometric information. Analysis of global distribution was conducted using the webpage mapping implement GunnMap2 (http://lert.co.nz/map/).

Results:
Publications in this field were retrieved from the Web of Science Core Collection database, and 189 articles met the final inclusion criteria. The most influential authors, institutions, journals, and countries were Ralph MA from the University of Manchester, Harvard University, Neuropsychologia, and the USA, respectively.

Conclusion:
This study revealed publication patterns and emerging trends in the literature, providing a detailed and objective overview of the current state of research on repetitive transcranial magnetic stimulation for the treatment of aphasia. This information will be of great benefit to anyone seeking information about this field and can serve as a reference guide for researchers aiming to conduct further research.
Testicular ischemia secondary to acute epididymitis: A case report
Authors: Wang Zhichao , Qiu Mengzhen , Gao Xinghua , Zhang Longyang 
Published: May 2023

Rationale:
Rare side effects of acute epididymitis include testicular infarction and ischemia. Distinguishing them from testicular torsion is challenging, both clinically and radiologically. However, only a few such cases have been reported to date.

Patient concerns:
A 12-year-old child presented with persistent right testicular pain for 3 days. It developed after trauma and was accompanied by gradual swelling and enlargement of the right scrotum, with nausea and vomiting. Scrotal color Doppler ultrasonography demonstrated right epididymitis, right scrotal wall swelling, and right testicular torsion. Routine blood tests revealed leukocyte and neutrophil counts were both above normal.

Diagnosis:
Scrotal exploration revealed edema and adhesions in all layers of the scrotal wall. The right testicle was pale. The patient was diagnosed with testicular ischemia secondary to acute epididymitis.

Interventions:
The patient underwent simultaneous lower spermatic cord sheath dissection and decompression, testicular sheath reversal, and right testicular fixation.

Outcomes:
Blood flow to the testicles gradually recovered after decompression, as did the color. Postoperatively, the patient’s scrotal swelling and pain improved significantly.

Lessons:
Despite the rarity of this condition, it is a potentially serious consequence of epididymitis and should be considered when patients experience sudden scrotal pain.
Cannabis and Cannabinoids in Multiple Sclerosis: From Experimental Models to Clinical Practice—A Review
Authors: Sirbu Carmen-Adella , Georgescu Ruxandra , Pleşa Florentina Cristina , Paunescu Alina , Marilena Ţânţu Monica , Nicolae Alina Crenguţa , Caloianu Ionut , Mitrica Marian 
Published: May 2023

Background:
As far as 80% of people diagnosed with multiple sclerosis (MS) experience disabling symptoms in the course of the disease, such as spasticity and neuropathic pain. As first-line symptomatic therapy is associated with important adverse reactions, cannabinoids have become increasingly popular among patients with MS. This review intends to provide an overview of the evidence of the role of cannabinoids in treating symptoms related to MS and to encourage further research on this matter.

Areas of Uncertainty:
To date, the evidence supporting the role of cannabis and its derivatives in alleviating the MS-related symptoms comes only from studies on experimental models of demyelination. To the best of our knowledge, relatively few clinical trials inquired about the therapeutic effects of cannabinoids on patients with MS, with variable results.

Data Sources:
We conducted a literature search through PubMed and Google Scholar from the beginning until 2022. We included articles in English describing the latest findings regarding the endocannabinoid system, the pharmacology of cannabinoids, and their therapeutic purpose in MS.

Results:
Evidence from preclinical studies showed that cannabinoids can limit the demyelination process, promote remyelination, and have anti-inflammatory properties by reducing immune cell infiltration of the central nervous system in mice with experimental autoimmune encephalomyelitis. Moreover, it has been established that experimental autoimmune encephalomyelitis mice treated with cannabinoids experienced a significant reduction of symptoms and slowing of the disease progression. Given the complexity of human immune and nervous systems, cannabinoids did not have the anticipated effects on human subjects. However, data obtained from clinical trials showed some beneficial results of cannabinoids as a single or as add-on therapy in reducing the spasticity and pain related to MS.

Conclusion:
Considering their various mechanisms of action and good tolerability, cannabinoids remain an interesting therapy for spasticity and chronic pain related to MS.
A Survey of Myopia Correction Pattern of Children and Parent's Attitudes in China
Authors: Yang Yongmei , Jiang Jun 
Published: May 2023

ABSTRACTSIGNIFICANCEThis survey provides information about Chinese children's myopia correction status and parents' attitudes toward myopia correction.PURPOSEUnder the background of a guideline of appropriate techniques for the prevention and control of children's myopia, this study aimed to investigate the current myopia correction pattern of children and parents' attitudes.METHODSTwo self-administered questionnaires were distributed to 684 children with myopia corrections and 450 parents (384 mothers and 66 fathers) to explore children's myopia correction patterns and parental attitudes. The questionnaire investigated the pattern of children's myopia correction, prescribing of children's myopia correction, the incidence of high myopia, parental attitudes toward various myopia corrections methods, and preferred initial age for contact lens usage.RESULTSSingle-vision spectacles (n = 600; 88.2 ± 7.4%) are widely used in China because of their comfort and affordability. More than 80% of children use single-vision spectacles prescribed by ophthalmologists and opticians. Children who used single-vision spectacles at an earlier age had more incidence of high myopia (18.4 ± 4.2%) than those who used single-vision spectacles at a later age (0.7 ± 0.9%). Effective myopia control was the primary reason parents preferred to choose different optical corrections, followed by safety, convenience, clarity, affordability, comfort, and other reasons. The survey indicated that 52.4% of parents whose children used orthokeratology lenses would have preferred safe and convenient options if available. In addition, 50% of the parents preferred delaying their children's use of orthokeratology lenses and other contact lenses to an older age.CONCLUSIONSSingle-vision spectacles are still a popular option to correct myopia in children. There was a demonstrated increase in myopia in children who used single spectacles at an earlier age. Parents' attitudes were important factors for selecting myopia corrections in children.
Regularly Playing First-Person Shooter Videogames Improves Dynamic Visual Acuity
Authors: Argilés Marc , Erickson Graham , Quevedo-Junyent Lluïsa 
Published: May 2023

ABSTRACT

Significance
This study investigated the dynamic visual acuity (DVA) in young adults that play action video games regularly compared with non-action video games players and those without regular experience in videogame play. The results indicate better performance in some measurements of DVA in action video game players.

Purpose
This study aims to provide new insights about performance on DVA assessments in young adults who play action video games regularly.

Methods
A cross-sectional study was conducted between action video game and non-action video game players with 47 participants, range from 20 to 30 years old. DVA with 2 different angular velocities, 57 °/s and 28.5 °/s and three different contrast, 100%, 50% and 10% were evaluated. A second analysis with 33 participants compared DVA between action video game players and non-experience videogames or less than 1 hour/week in gaming.

Results
Dynamic visual acuity in the first analysis revealed a non-statistical significance between groups in all the experimental conditions with 57 °/s and 28.5 °/s in three different contrasts. The second analysis with 33 participants revealed a statistical significance in DVA at 57 °/s and 28.5 °/s with contrast 100 %, P = .003 and P < .001, respectively.

Conclusions
Dynamic visual acuity seems to have better performance in young adults spending more than 5 hours/week with action videogames, mostly first-person shooter games.
The Emerging Leaders in Public Health Initiative: Leadership Development to Advance Public Health Practice
Authors: Schenck Anna P. , Suttie Janet , Orton Stephen , Carter-Edwards Lori , Herrick Jeannine , Meadows Phyllis D. , Dinkin Donna R. 
Published: May 2023

Context:
Effective leadership is essential for governmental public health agencies to promote and protect the health of their communities.

Objective:
The Emerging Leaders in Public Health Initiative, a program of The Kresge Foundation, was implemented to strengthen leadership in governmental public health. We seek to examine lessons from the initiative to contribute to the field a better understanding of leadership development practices.

Design:
An external evaluator conducted a retrospective analysis of participant responses postinitiative to assess the overall impact of the initiative and explore which components were most valuable.

Setting:
United States.

Participants:
Directors and other staff from governmental public health agencies were recruited in 2-person teams to participate in 3 successive cohorts.

Intervention:
Drawn from adaptive leadership principles, a framework was developed to guide the selection and implementation of educational and experiential activities. Participants were challenged to develop a new role for their public health agency, which provided a learning laboratory to practice individual and team leadership skills. The Kresge Foundation provided participants with a resource grant and a National Program Office offered convenings, webinars, coaching, and technical assistance over the 18 months of the developmental experience.

Main Outcome Measures:
Satisfaction, perceived value of components, and future intentions were assessed from participants in cohorts II and III (n = 70). The overall response rate was 93%.

Results:
One hundred four diverse leaders from 52 agencies, representing 30 states participated in the initiative. Participants were extremely satisfied with the program (94%) and indicated a strong likelihood of recommending it to a colleague (96%). Unrestricted grant funding, peer learning, and in-person learning sessions were the program components rated most highly valuable.

Conclusions:
This initiative offers insights into principles and processes to be considered for future public health leadership development.
Symptomatic neuroma development following en bloc resection of skeletal and soft tissue tumors: A retrospective analysis of 331 cases
Authors: Aslami Zohra V. , Leland Christopher R. , Strike Sophie A. , Forsberg Jonathan A. , Morris Carol D. , Levin Adam S. , Tuffaha Sami H. 
Published: May 2023

Background:
While symptomatic neuroma formation has been described in other patient populations, these data have not been studied in patients undergoing resection of musculoskeletal tumors. This study aims to characterize the incidence and risk factors of symptomatic neuroma formation following en bloc resection in this population.

Methods:
We retrospectively reviewed adults undergoing en bloc resections for musculoskeletal tumors at a high-volume sarcoma center from 2014-2019. We included en bloc resections for an oncologic indication and excluded non-en bloc resections, primary amputations, and patients with insufficient follow-up. Data are provided as descriptive statistics and multivariable regression modeling was performed.

Results:
We included 231 patients undergoing 331 en bloc resections (46% female; mean age 52 years). Nerve transection was documented in 87 resections (26%). There were 81 symptomatic neuromas (25%) meeting criteria of Tinel sign or pain on exam and neuropathy in the distribution of suspected nerve injury. Factors associated with symptomatic neuroma formation included age 18-39 (aOR, 3.6; 95% CI, 1.5-8.4; p < 0.01) and 40-64 (aOR, 2.2; 95% CI, 1.1-4.6; p = 0.04), multiple resections (aOR, 3.2; 95% CI, 1.7-5.9; p < 0.001), preoperative neuromodulator requirement (aOR, 2.7; 95% CI 1.2-6.0; p = 0.01) and resection of fascia or muscle (aOR, 0.5; 95% CI, 0.3-1.0; p = 0.045).

Conclusion:
Our results highlight the importance of adequate preoperative optimization of pain control and intraoperative prophylaxis for neuroma prevention following en bloc resection of tumors, particularly for younger patients with a recurrent tumor burden.

Level of Evidence:
Level III, prognostic study.
Co-development and bidirectional associations between psychological stress and obesity in school-aged children: A longitudinal study in China
Authors: Tang Lei , Yin Ruoyun , Xi Xuan , Hu Qian , Zhang Fan , Liu Qin 
Published: May 2023

Abstract

Objective
Psychological stress (PS) has always been a hot topic for researchers to investigate the potential determinants of childhood overweight/obesity. Up to now, cohort studies investigating the relationship between PS and childhood obesity have used different ways to assess PS, different indicators to measure obesity, different analysis methods, and the results were also inconsistent.

Methods
Data were obtained from the second to eighth follow-up of an ongoing cohort of school-aged children in Chongqing, China (June 2015 - June 2018) with seven waves (W1-W7, NW1 = 1419). The latent growth curve model (LGCM) was used to estimate the co-developmental trends between PS and obesity (BMI, WHtR). Random intercept cross-lagged panel models (RI-CLPM) were constructed to examine their longitudinal bidirectional associations.

Results
The changes in PS and obesity (BMI, WHtR) were co-developing (rBMI
= -1.105, P = 0.003; rWHtR
= -0.991, P = 0.004). Longitudinal models showed significant negative correlations between PS and obesity at the between-person level (rBMI
= -4.993; rWHtR
= -1.591). BMI at W3 could negatively predict PS six months later (β = -1.508, P = 0.027), and WHtR at W1 could negatively predict PS at W3 (β = -2.809, P = 0.014). Different aspects of PS had different associations with obesity. Notably, there was a significant reciprocal relationship between peer interaction PS and obesity.

Conclusions
Different aspects of PS were differentially associated with obesity. Notably, there may be a clear reciprocal relationship between peer interaction PS and obesity. These findings provide new directions for protecting children's mental health to prevent or control childhood overweight/obesity.
Systematic review of alternative HIV pre-exposure prophylaxis (PrEP) care delivery models to improve PrEP services
Authors: Kamitani Emiko , Mizuno Yuko , DeLuca Julia B. , Collins Charles B. 
Published: May 2023

Objectives:
To identify types, evidence, and study gaps of alternative HIV preexposure prophylaxis (PrEP) care delivery models in the published literature.

Design:
Systematic review and narrative synthesis

Methods:
We searched in the US Centers for Disease Control and Prevention (CDC) Prevention Research Synthesis (PRS) database through December 2022 (PROSPERO CRD42022311747). We included studies published in English that reported implementation of alternative PrEP care delivery models. Two reviewers independently reviewed the full text and extracted data by using standard forms. Risk of bias was assessed using the adapted Newcastle-Ottawa Quality Assessment Scale. Those that met our study criteria were evaluated for efficacy against CDC Evidence-Based Intervention (EBI) or Evidence-Informed Intervention (EI) criteria or Health Resources and Services Administration Emergency Strategy (ES) criteria, or for applicability by using an assessment based on the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework.

Results:
This review identified 16 studies published between 2018-2022 that implemented alternative prescriber (n = 8), alternative setting for care (n = 4), alternative setting for laboratory screening (n = 1), or a combination of the above (n = 3) . The majority of studies were US-based (n = 12) with low risk of bias (n = 11). None of the identified studies met EBI, EI, or ES criteria. Promising applicability was found for pharmacists prescribers, telePrEP , and mail-in testing.

Conclusions:
Delivery of PrEP services outside of the traditional care system by expanding providers of PrEP care (e.g., pharmacist prescribers), as well as the settings of PrEP care (i.e., telePrEP) and laboratory screening (i.e., mail-in testing) may increase PrEP access and care delivery.
Dietary Iron Intake and HIV-Related Outcomes Among Adults Initiating Antiretroviral Therapy in Tanzania
Authors: Abioye Ajibola Ibraheem , Hughes Michael D. , Sudfeld Christopher R. , Noor Ramadhani Abdallah , Isanaka Sheila , Lukmanji Zohra , Mugusi Ferdinand , Fawzi Wafaie W. 
Published: May 2023

Objective:Anemia is highly prevalent among people living with HIV (PLWHIV) and is often due to iron deficiency. This study evaluated the relationship of dietary iron intake levels and sources with mortality and clinical outcomes among adults initiating HAART.Design:We conducted a secondary analysis of a multivitamin supplementation trial among 2293 PLWHIV initiating HAART in Dar es Salaam, Tanzania.Methods:Dietary iron intake was assessed with a food frequency questionnaire at HAART initiation, and participants followed until death or censoring. Total, animal-, and plant-sourced iron were categorized into quartiles. Intake of food groups was categorized into 0–1, 2–3, and ≥4 servings/wk. Cox proportional hazards models estimated hazard ratios for mortality and incident clinical outcomes.Results:There were 175 deaths (8%). Red meat intake was associated with a lower risk of all-cause mortality (HR: 0.54; 95% CI: 0.35 to 0.83), AIDS-related mortality (HR: 0.49; 95% CI: 0.28 to 0.85), and severe anemia (HR: 0.57; 95% CI: 0.35 to 0.91), when intake ≥4 servings/wk, compared with 0–1 servings/wk. Legume intake was a lower risk of associated with all-cause mortality (HR: 0.49; 95% CI: 0.31 to 0.77) and AIDS-related mortality (HR: 0.37; 95% CI: 0.23 to 0.61), when intake ≥4 servings/wk, compared with 0–1 servings/wk. Although total dietary iron and overall plant-sourced iron intake were not associated with the risk of mortality or HIV-related outcomes, the highest quartile of animal-sourced iron intake was associated with a lower risk of all-cause mortality (HR: 0.56; 95% CI: 0.35 to 0.90) and a lower risk of AIDS-related mortality (HR: 0.50; 95% CI: 0.30 to 0.90), compared with the lowest quartile.Conclusion:Intake of iron-rich food groups may be associated with a lower risk of mortality and critical HIV-related outcomes among adults initiating HAART.Trial registration:The parent trial was registered at Clinicaltrials.gov. Identifier: NCT00383669.
CIRC_0026466 KNOCKDOWN PROTECTS HUMAN BRONCHIAL EPITHELIAL CELLS FROM CIGARETTE SMOKE EXTRACT–INDUCED INJURY BY PROMOTING THE MIR-153-3P/TRAF6/NF-ΚB PATHWAY
Authors: Wang Cong , Tang Yanfen , Hou Haihui , Su Chengcheng , Gao Yemeng , Yang Xu 
Published: May 2023

ABSTRACT

Background: Considerable data have shown that circular RNAs (circRNAs) mediate the pathogenesis of chronic obstructive pulmonary disease (COPD). The study aims to analyze the function and mechanism of circ_0026466 in COPD. Methods: Human bronchial epithelial cells (16HBE) were treated with cigarette smoke extract (CSE) to establish a COPD cell model. Quantitative real-time polymerase chain reaction and Western blot were used to detect the expression of circ_0026466, microRNA-153-3p (miR-153-3p), TNF receptor associated factor 6 (TRAF6), cell apoptosis-related proteins, and NF-κB pathway-related proteins. Cell viability, proliferation, apoptosis, and inflammation were investigated by cell counting kit-8, EdU assay, flow cytometry, and enzyme-linked immunosorbent assay, respectively. Oxidative stress was evaluated by lipid peroxidation malondialdehyde assay kit and superoxide dismutase activity assay kit. The interaction between miR-153-3p and circ_0026466 or TRAF6 was confirmed by dual-luciferase reporter assay and RNA pull-down assay. Results: Circ_0026466 and TRAF6 expression were significantly increased, but miR-153-3p was decreased in the blood samples of smokers with COPD and CSE-induced 16HBE cells when compared with controls. CSE treatment inhibited the viability and proliferation of 16HBE cells but induced cell apoptosis, inflammation, and oxidative stress, but these effects were attenuated after circ_0026466 knockdown. Circ_0026466 interacted with miR-153-3p and regulated CSE-caused 16HBE cell damage by targeting miR-153-3p. Additionally, TRAF6, a target gene of miR-153-3p, regulated CSE-induced 16HBE cell injury by combining with miR-153-3p. Importantly, circ_0026466 activated NF-κB pathway by targeting the miR-153-3p/TRAF6 axis. Conclusion: Circ_0026466 absence protected against CSE-triggered 16HBE cell injury by activating the miR-153-3p/TRAF6/NF-κB pathway, providing a potential therapeutic target for COPD.