bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Approach to Predict Tributary Phosphorus Loads Using Machine Learning– and Physics-Based Modeling Systems
Authors: Feng Chang Christina , Astitha Marina , Yuan Yongping , Tang Chunling , Vlahos Penny , Garcia Valerie , Khaira Ummul 
Published: May 2023

Abstract
Tributary phosphorus (P) loads are one of the main drivers of eutrophication problems in freshwater lakes. Being able to predict P loads can aid in understanding subsequent load patterns and elucidate potential degraded water quality conditions in downstream surface waters. We demonstrate the development and performance of an integrated multimedia modeling system that uses machine learning (ML) to assess and predict monthly total P (TP) and dissolved reactive P (DRP) loads. Meteorological variables from the Weather Research and Forecasting (WRF) Model, hydrologic variables from the Variable Infiltration Capacity model, and agricultural management practice variables from the Environmental Policy Integrated Climate agroecosystem model are utilized to train the ML models to predict P loads. Our study presents a new modeling methodology using as testbeds the Maumee, Sandusky, Portage, and Raisin watersheds, which discharge into Lake Erie and contribute to significant P loads to the lake. Two models were built, one for TP loads using 10 environmental variables and one for DRP loads using nine environmental variables. Both models ranked streamflow as the most important predictive variable. In comparison with observations, TP and DRP loads were predicted very well temporally and spatially. Modeling results of TP loads are within the ranges of those obtained from other studies and on some occasions more accurate. Modeling results of DRP loads exceed performance measures from other studies. We explore the ability of both ML-based models to further improve as more data become available over time. This integrated multimedia approach is recommended for studying other freshwater systems and water quality variables using available decadal data from physics-based model simulations.
Wind Dependencies of Deep Cycle Turbulence in the Equatorial Cold Tongues
Authors: Moum James N. , Smyth William D. , Hughes Kenneth G. , Cherian Deepak , Warner Sally J. , Bourlès Bernard , Brandt Peter , Dengler Marcus 
Published: May 2023

Abstract
Several years of moored turbulence measurements from χpods at three sites in the equatorial cold tongues of Atlantic and Pacific Oceans yield new insights into proxy estimates of turbulence that specifically target the cold tongues. They also reveal previously unknown wind dependencies of diurnally varying turbulence in the near-critical stratified shear layers beneath the mixed layer and above the core of the Equatorial Undercurrent that we have come to understand as deep cycle (DC) turbulence. Isolated by the mixed layer above, the DC layer is only indirectly linked to surface forcing. Yet, it varies diurnally in concert with daily changes in heating/cooling. Diurnal composites computed from 10-min averaged data at fixed χpod depths show that transitions from daytime to nighttime mixing regimes are increasingly delayed with weakening wind stress τ. These transitions are also delayed with respect to depth such that they follow a descent rate of roughly 6 m h−1, independent of τ. We hypothesize that this wind-dependent delay is a direct result of wind-dependent diurnal warm layer deepening, which acts as the trigger to DC layer instability by bringing shear from the surface downward but at rates much slower than 6 m h−1. This delay in initiation of DC layer instability contributes to a reduction in daily averaged values of turbulence dissipation. Both the absence of descending turbulence in the sheared DC layer prior to arrival of the diurnal warm layer shear and the magnitude of the subsequent descent rate after arrival are roughly predicted by laboratory experiments on entrainment in stratified shear flows.

Significance Statement
Only recently have long time series measurements of ocean turbulence been available anywhere. Important sites for these measurements are the equatorial cold tongues where the nature of upper-ocean turbulence differs from that in most of the world’s oceans and where heat uptake from the atmosphere is concentrated. Critical to heat transported downward from the mixed layer is the diurnally varying deep cycle of turbulence below the mixed layer and above the core of the Equatorial Undercurrent. Even though this layer does not directly contact the surface, here we show the influence of the surface winds on both the magnitude of the deep cycle turbulence and the timing of its descent into the depths below.
Evaluating Medium-Range Forecast Performance of Regional-Scale Circulation Patterns
Authors: Obarein Omon A. , Lee Cameron C. , Smith Erik T. , Sheridan Scott C. 
Published: May 2023

Abstract
Accurate subseasonal-to-seasonal (S2S) weather forecasts are crucial to making important decisions in many sectors. However, significant gaps exist between the needs of society and what forecasters can produce, especially at weekly and longer lead times. We hypothesize that by clustering atmospheric states into a number of predefined categories, the noise can be reduced and, consequently, medium-range forecasts can be improved. Self-organizing map (SOM)-based clustering was used on daily mean sea level pressure (MSLP) data from the North American Regional Reanalysis to categorize the synoptic-scale circulation for eastern North America from 1979 to 2016 into 28 discrete patterns. Then, using two goodness-of-fit metrics, the relative skill of four different forecasting methods over a 90-day lead time was studied: 1) a circulation pattern (CP) forecast, 2) raw forecast output from the Climate Forecast System (CFS) operated by the National Centers for Environmental Prediction (NCEP), 3) a simple climatology forecast, and 4) a simple persistence forecast. As expected, forecast skill of both the CP forecast and the raw CFS forecast generally decreased rapidly from the first day, coming to parity with the skill of climatology after 10–12 days when using correlation, and at 7–10 days when using the root-mean-square error (RMSE). Most importantly, this study found that the CP forecast was the most skillful forecast method over the 8–11-day lead time when using RMSE. On a spatial basis, the skill of the CP forecast and the raw CFS decreases latitudinally from north to south. This study thus demonstrates the potential utility of categorical or circulation pattern–based forecasting at 1–2-week lead times.
Dataset dependency of low-density lipoprotein-cholesterol estimation by machine learning
Authors: Hidekazu Ishida , Nagasawa Hiroki , Yamamoto Yasuko , Doi Hiroki , Saito Midori , Ishihara Yuya , Fujita Takashi , Ishida Mariko , Kato Yohei , Kikuchi Ryosuke , Matsunami Hidetoshi , Takemura Masao , Ito Hiroyasu , Saito Kuniaki 
Published: May 2023

Objectives We evaluated the applicability of a machine learning–based low-density lipoprotein-cholesterol (LDL-C) estimation method and the influence of the characteristics of the training datasets. Methods Three training datasets were chosen from training datasets: health check-up participants at the Resource Center for Health Science ( N = 2664), clinical patients at Gifu University Hospital ( N = 7409), and clinical patients at Fujita Health University Hospital ( N = 14,842). Nine different machine learning models were constructed through hyperparameter tuning and 10-fold cross-validation. Another test dataset of another 3711 clinical patients at Fujita Health University Hospital was selected as the test set used for comparing and validating the model against the Friedewald formula and the Martin method. Results The coefficients of determination of the models trained on the health check-up dataset produced coefficients of determination that were equal to or inferior to those of the Martin method. In contrast, the coefficients of determination of several models trained on clinical patients exceeded those of the Martin method. The means of the differences and the convergences to the direct method were higher for the models trained on the clinical patients' dataset than for those trained on the health check-up participants' dataset. The models trained on the latter dataset tended to overestimate the 2019 ESC/EAS Guideline for LDL-cholesterol classification. Conclusion Although machine learning models provide valuable method for LDL-C estimates, they should be trained on datasets with matched characteristics. The versatility of machine learning methods is another important consideration.
LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma
Authors: Qi Puliang , Yexie Zhihua , Xue Chen , Huang Guoqiang , Zhao Zhanxue , Zhang Xikun 
Published: May 2023

Background Colorectal carcinoma (CRC) ranks the third most frequent malignancy worldwide. Makorin RING zinc finger-2 (MKRN2) has been identified as a tumor suppressor in CRC, and the bioinformatics prediction indicated that some non-coding RNAs (ncRNAs) that directly or indirectly regulate MKRN2 might play critical roles in CRC progression. This study aimed to analyze the regulatory effect of LINC00294 on CRC progression, and to explore the underlying mechanisms by assessing miR-620 and MKRN2. The potential prognostic value of the ncRNAs and MKRN2 was also investigated. Methods The expression of LINC00294, MKRN2, miR-620 was examined by qRT-PCR. Cell counting kit-8 assay was used to assess the proliferation of CRC cells. Transwell assay was used to evaluate the migration, invasion of CRC cells. Kaplan-Meier method and log-rank test were used to perform comparative analysis of overall survival in CRC patients. Results Lower expression of LINC00294 was observed in both CRC tissues and cell lines. In CRC cells, LINC00294 overexpression inhibited cell proliferation, migration and invasion, but these effects were directly reversed by the overexpression of miR-620, which was demonstrated as a target of LINC00294. Additionally, MKRN2 was found to be a target gene of miR-620, and might mediate the regulatory function of LINC00294 in CRC progression. In CRC patients, low LINC00294, MKRN2 and high miR-620 expression was associated poor overall survival of CRC. Conclusions LINC00294/miR-620/MKRN2 axis had the potential to provide prognostic biomarkers for CRC patients, and negatively regulated the malignant progression of CRC cells, including proliferation, migration and invasion.
Healthcare Providers’ Experiences of Caring for Patients With COVID-19 Requiring Extracorporeal Membrane Oxygenation Support
Authors: Constantine Lori , DeCicco Danielle , Carpenter Roger D. , Pockl Stephanie , Seachrist Katherine B. , Navia R. Osvaldo 
Published: May 2023

Background Coronavirus 19 (COVID-19) affected healthcare workers (HCW) in ways more than increasing the volume of patients needing care. Increased numbers of patients at younger ages required support with extracorporeal membrane oxygenation (ECMO). Providing this care requires an interdisciplinary team. Aim This study explored the experiences of HCW caring for patients with COVID-19 on ECMO. Methods Face-to-face semi-structured interviews were conducted via videoconferencing, and transcript comparison was used for the analysis. Findings Open coding of the data generated 7 categories including (1) fearing the unknown, (2) confronting challenges in patient and/or family interactions, (3) encountering barriers to providing care, (4) facing moral distress, (5) working through exhaustion, (6) persevering by strengthening teamwork, (7) and acknowledging frustration with non-believers. Discussion HCW balanced pessimism and optimism while caring for patient with COVID-19 on ECMO. They used negative experiences caring for these patients to strength teamwork and bonding among peers. Conclusion The practice implications for caring for patients with COVID-19 on ECMO include viligance by clinician and organization to protect the wellbeing of healthcare providers, particularly in ICU and ECMO units were moral distress and burnout can be high.
Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome
Authors: Li Xin , Zheng Yanlong , Ge Qiao , Dai Zhenbo , Zhou Dejun , Tian Xiangdong 
Published: May 2023

Introduction Neuroblastoma is the most common extracranial solid tumor in children. Patients with high-risk neuroblastoma have a 5-year survival rate less than 50% after extensive treatment. Signaling pathways control cell fate decisions that dictate the behavior of tumor cells. The deregulation of signaling pathways is etiological in cancer cells. Thus, we speculated that the pathway activity of neuroblastoma contains more prognostic information and therapeutic targets. Methods Using a footprint-based method, we calculated the activity of fourteen pathways in neuroblastoma. Through stepwise Cox regression analyses, we established a three-gene prognostic signature whose predictive performance was evaluated by external validation. Combining a single-cell sequencing dataset, the most active pathways in high-risk neuroblastoma were found. Results We found that several pathway activities were correlated with neuroblastoma outcomes. We built a three-gene model comprising DLK1, FLT3, and NTRK1, which exhibited superior internal and external performances. We created a nomogram that combines clinical characteristics to aid in the selection and visualization of high-risk neuroblastoma patients. Furthermore, by integrating a single-cell sequencing dataset, we found that estrogen and MAPK were the most active pathways in high-risk neuroblastoma. Conclusion Our findings suggest that pathway-related therapies may hold promise for the treatment of high-risk neuroblastoma.
A Cross-Sectional Study Comparing Traumatic Alopecia Among B-Boys and B-Girls to Other Dance Styles and Its Impact on Dance Performance and Health
Authors: Hall Marshall , Lim Henry , Kim Suhhyun , Fulda Kimberly G. , Surve Sajid A. 
Published: May 2023

Introduction: Breaking, often mislabeled as breakdancing in the media, is a dance style originating from the Bronx of New York in the early 1970s. A unique condition in this population is a form of alopecia known as “headspin hole,” or “breakdancer overuse syndrome” of the scalp. This form of hair loss may show a variety of patterns based on the activities of the dancer. The purpose of this study was to investigate the relationship between alopecia and breaking, the level of concern dancers have regarding hair loss, barriers to medical treatment, and how it affects their dancing. Methods: This was a cross-sectional study using an online survey. The survey addressed participants’ demographics, hair, dancing styles, training, and health history. Questions about the effects of hair loss on the participants were also asked. Results: This study found that there was a significant difference in hair loss among breakers compared to non-breakers. This was not seen after controlling for age and sex. However, the concern for hair loss was significant even after controlling for these variables. Similarly, hair loss was significantly associated with the frequency of headspins. Despite these concerns, breakers were less likely to seek medical attention. Conclusions: This study showed that there are significant disparities in hair loss between breaking and other dance styles. Hair loss due to breaking has been shown to have significant effects on an individual’s concerns, which may be compounded by the fact that this population is less likely to seek out medical care and have significantly greater substance use compared to the other dancers surveyed. Further research is necessary to investigate interventions to prevent and treat hair loss in this population and the means to decrease the gap in health care in the dance population.
The influence of personality on the quality of vision after multifocal intraocular lens implantation
Authors: Pinheiro Rosa L. , Raimundo Miguel , Gil João Q. , Henriques Jorge , Rosa Andreia M. , Quadrado Maria João , Lobo Conceição , Murta Joaquim N. 
Published: May 2023

Objective To assess the possible correlation between patients’ personality traits and subjective perception of quality of vision (QoV), after multifocal intraocular lens (mIOL) implantation. Methods patients who had bilateral implantation of a non-diffractive X-WAVE or a trifocal lens were assessed 6 months postoperatively. Patients answered the NEO-Five Factor Inventory (NEO-FFI-20) questionnaire (“Big Five five-factor personality model”) to examine their personality. Six months following surgery, patients were asked to fill a QoV questionnaire where they graded the frequency of 10 common visual symptoms. Primary outcomes were to evaluate the correlation between personality scores and the reported frequency of visual disturbances. Results The study comprised 20 patients submitted to bilateral cataract surgery, 10 with a non-diffractive X-WAVE lens (AcrySof® IQ Vivity) and 10 with a trifocal lens (AcrySof® IQ PanOptix). Mean age was 60.23 (7.06) years. Six months following surgery, patients with lower scores of conscientiousness and extroversion reported a higher frequency of visual disturbances (blurred vision, P  =  .015 and P  =  .009, seeing double images P  =  .018 and P  =  .006, and having difficulties focusing, P  =  .027 and P  =  .022, respectively). In addition, patients with high neuroticism scores had more difficulty focusing ( P  =  .033). Conclusions In this study, personality traits such as low conscientiousness and extroversion and high neuroticism significantly influenced QoV perception 6 months after bilateral multifocal lens implantation. Patients’ personality questionnaires could be a useful preoperative assessment test to a mIOL.
Clinical characteristics of gyrate atrophy compared with a gyrate atrophy-like retinal phenotype
Authors: Pauleikhoff L. , Weisschuh N. , Lentzsch A. , Spital G. , Krohne T. U. , Agostini H. , Lange C.A.K. 
Published: May 2023

Introduction Gyrate atrophy (GA) is a rare retinal dystrophy due to biallelic pathogenic variants in the ornithine aminotransferase (OAT) gene, causing a 10-fold increase in plasma ornithine levels. It is characterized by circular patches of chorioretinal atrophy. However, a GA-like retinal phenotype (GALRP) without elevated ornithine levels has also been reported. The aim of this study is to compare the clinical characteristics of GA and GALRP and to identify possible discriminators. Methods A multicenter, retrospective chart review was performed at three German referral centres on patient records between 01/01/2009 and 31/12/2021. Records were screened for patients affected by GA or GALRP. Only patients with examination results for plasma ornithine levels and / or genetic testing of the OAT gene were included. Further clinical data was gathered where available. Results Ten patients (5 female) were included in the analysis. Three suffered from GA, while seven had a GALRP. Mean age (± SD) at onset of symptoms was 12.3 (± 3.5) years for GA compared with 46.7 (± 14.0) years for GALRP patients (p = 0.002). Mean degree of myopia was higher in GA (−8.0 dpt. ± 3.6) compared to GALRP patients (−3.8 dpt. ± 4.8, p = 0.04). Interestingly, all GA patients showed macular oedema, while only one GALRP patient did. Only one patient with GALRP had a positive family history, while two were immunosuppressed. Discussion Age of onset, refraction and presence of macular cystoid cavities appear to be discriminators between GA and GALRP. GALRP may encompass both genetic and non-genetic subtypes.
Effects of Physical Exercise Program for Older Family Caregivers of Persons With Dementia
Authors: Kim Ji-yeon , Tak Sunghee H , Lee Jaegyeong , Choi Hyein 
Published: May 2023

Self-efficacy plays a major role in improving health behaviors. The purpose of this study was to examine the effects of a physical activity program that utilized four self-efficacy resources in older family caregivers of persons with dementia. Quasi-experimental pretest-posttest design with control group was used. Study participants were 64 family caregivers aged 60 years or older. The intervention included a 60-minute group session per week for 8 weeks along with individual counseling and text messages. The experimental group showed significantly higher self-efficacy than the control group. In addition, physical function, quality of life related to health, caregiving burden, and depressive symptoms were significantly improved in the experimental group in comparison with those of control group. These findings suggest that a physical activity program with a focus on the resources of self-efficacy may be not only feasible but also effective for older family caregivers of persons with dementia.
Emotion dysregulation is heightened in autistic females: A comparison with autistic males and borderline personality disorder
Authors: Weiner Luisa , Costache Madalina Elena , Bemmouna Doha , Rabot Juliette , Weibel Sébastien , Dubreucq Marine , Dubreucq Julien , Coutelle Romain 
Published: May 2023

Background: Emotion dysregulation is increasingly recognized as highly prevalent and impairing in autistic individuals. Yet, a large majority of studies have considered emotion dysregulation in youth only, and most of them did not consider sex differences in emotion dysregulation manifestation. Objectives: In the present study, we aim to investigate sex differences relative to emotion dysregulation in autistic adults without intellectual disability as well as its relationship with different factors potentially involved in emotion dysregulation (e.g. camouflaging, alexithymia, suicidality, quality of life). Self-reported emotion dysregulation will be assessed in autistic adults but also in females with borderline personality disorder, given that emotion dysregulation is particularly enhanced in this population. Design: Cross-sectional, prospective, controlled. Methods: Twenty-eight autistic females, 22 autistic males and 24 females with borderline personality disorder were recruited from a dialectical behavior therapy program waiting list. They completed several self-report questionnaires measuring emotion dysregulation, alexithymia, suicidality, quality of life, camouflaging borderline symptoms and autism severity. Results: Most emotion dysregulation subscale scores and alexithymia scores were heightened in autistic females compared to females with borderline personality disorder and, to a lesser extent, compared to autistic males. Independently of borderline personality disorder symptoms, emotion dysregulation was related to alexithymia and poorer psychological health in autistic females, whereas it was mostly related to autism severity, poorer physical health and living conditions in autistic males. Conclusion: Our results suggest that emotion dysregulation is a major difficulty of autistic adults without intellectual disability eligible for dialectical behavior therapy, and this is especially the case for autistic females. There seem to be different sex-specific factors involved in emotion dysregulation found in autistic adults, which highlight the need to target-specific domains (e.g. alexithymia) in the treatment of emotion dysregulation in autistic females. ClinicalTrials.gov Identifier: NCT04737707 https://clinicaltrials.gov/ct2/show/NCT04737707