bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicoradiological outcomes after radical radiotherapy for lung cancer in patients with interstitial lung disease
Authors: Walls Gerard M , McMahon Michael , Moore Natasha , Nicol Patrick , Bradley Gemma , Whitten Glenn , Young Linda , O'Hare Jolyne M , Lindsay John , Connolly Ryan , Linden Dermot , Ball Peter A , Hanna Gerard G , McAleese Jonathan 
Published: April 2023

Objective: Interstitial lung disease (ILD) is relatively common in patients with lung cancer with an incidence of 7.5%. Historically pre-existing ILD was a contraindication to radical radiotherapy owing to increased radiation pneumonitis rates, worsened fibrosis and poorer survival compared with non-ILD cohorts. Herein, the clinical and radiological toxicity outcomes of a contemporaneous cohort are described. Methods: Patients with ILD treated with radical radiotherapy for lung cancer at a regional cancer centre were collected prospectively. Radiotherapy planning, tumour characteristics, and pre- and post-treatment functional and radiological parameters were recorded. Cross-sectional images were independently assessed by two Consultant Thoracic Radiologists. Results: Twenty-seven patients with co-existing ILD received radical radiotherapy from February 2009 to April 2019, with predominance of usual interstitial pneumonia subtype (52%). According to ILD-GAP scores, most patients were Stage I. After radiotherapy, localised (41%) or extensive (41%) progressive interstitial changes were noted for most patients yet dyspnoea scores (n = 15 available) and spirometry (n = 10 available) were stable. One-third of patients with ILD went on to receive long-term oxygen therapy, which was significantly more than the non-ILD cohort. Median survival trended towards being worse compared with non-ILD cases (17.8 vs 24.0 months, p = 0.834). Conclusion: Radiological progression of ILD and reduced survival were observed post-radiotherapy in this small cohort receiving lung cancer radiotherapy, although a matched functional decline was frequently absent. Although there is an excess of early deaths, long-term disease control is achievable. Advances in knowledge: For selected patients with ILD, long-term lung cancer control without severely impacting respiratory function may be possible with radical radiotherapy, albeit with a slightly higher risk of death.
Malaria Burden Stratification in Malawi- A report of a consultative workshop to inform the 2023-2030 Malawi Malaria Strategic Plan
Authors: Mategula Donnie , Mitambo Collins , Sheahan William , Masingi Mbeye Nyanyiwe , Gumbo Austin , Kwizombe Collins , Kawonga Jacob , Banda Benard , Hamuza Gracious , Kalanga Alinafe , Kamowa Dina , Kafulafula Jacob , Banda Akuzike , Twaibi Halima , Musa Esloyn , Kapito-Tembo Atupele , Ntwere Tapiwa , Chirombo James , Kalonde Patrick, Ken , Masambuka Maclear , Munthali Lumbani , Sakala Melody , Bangoura Abdoulaye , Gichuki Judy , Chipeta Michael Give , Galatas Adrade Beatriz , Kayange Michael , Terlouw Dianne J 
Published: April 2023

Background: Malawi's National Malaria Control Programme (NMCP) is developing a new strategic plan for 2023-2030 to combat malaria and recognizes that a blanket approach to malaria interventions is no longer feasible. To inform this new strategy, the NMCP set up a task force comprising 18 members from various sectors, which convened a meeting to stratify the malaria burden in Malawi and recommend interventions for each stratum. Methods: The burden stratification workshop took place from November 29 to December 2, 2022, in Blantyre, Malawi, and collated essential data on malaria burden indicators, such as incidence, prevalence, and mortality. Workshop participants reviewed the malaria burden and intervention coverage data to describe the current status and identified the districts as a appropriate administrative level for stratification and action. Two scenarios were developed for the stratification, based on composites of three variables. Scenario 1 included incidence, prevalence, and under-five all-cause mortality, while Scenario 2 included total malaria cases, prevalence, and under-five all-cause mortality counts. The task force developed four burden strata (highest, high, moderate, and low) for each scenario, resulting in a final list of districts assigned to each stratum. Results: The task force concluded with 10 districts in the highest-burden stratum (Nkhotakota, Salima, Mchinji, Dowa, Ntchisi, Mwanza, Likoma, Lilongwe, Kasungu and Mangochi) 11 districts in the high burden stratum (Chitipa, Rumphi, Nkhata Bay, Dedza, Ntcheu, Neno, Thyolo, Nsanje, Zomba, Mzimba and Mulanje) and seven districts in the moderate burden stratum (Karonga, Chikwawa, Balaka, Machinga, Phalombe, Blantyre, and Chiradzulu). There were no districts in the low-burden stratum. Conclusion: The next steps for the NMCP are to review context-specific issues driving malaria transmission and recommend interventions for each stratum. Overall, this burden stratification workshop provides a critical foundation for developing a successful malaria strategic plan for Malawi.
A revised prosocial behavior game: Testing associations with psychopathic traits and the effects of moral elevation using a randomized clinical trial
Authors: Sakai Joseph T. , Chintaluru Yaswanth , Raymond Kristen M. , McWilliams Shannon , Carter R. McKell , Winters Drew E. , Mikulich-Gilbertson Susan K. 
Published: April 2023

Background
Prosocial behavior is negatively associated with psychopathic traits and paradigms which measure prosocial behavior in the laboratory may be useful in better understanding moderators of this association.

Methods
We revised a previously validated game of prosocial behavior by including a new trial type (i.e., trials where the participant will lose money and the charity will gain money). This version of the game was administered online and participants were randomized to group (exposed to a control stimulus video or a video used to elicit moral elevation, i.e. a positive response to witnessing another’s act of kindness). We used repeated game administration to test whether a moral elevation stimulus affected game behavior and moderated the negative association between psychopathic traits and prosocial behavior.

Results
Prosocial behavior on the new trial types added in this revised game correlated strongly with prosocial behavior on the old trial type (i.e., trials where the participant will gain money and the charity will lose money; r = 0.71; p-value<0.001; n = 485). Graphing trial acceptance rates by trial characteristics demonstrated expected patterns of behavior. Number of prosocial choices on the game correlated with psychopathic trait score (Levenson Factor 1 score; r = -0.52; p-value<0.001). Game repetition with a control stimulus in between runs, supported high immediate test-retest reliability of overall game behavior. Exposure to the moral elevation stimulus in between runs did not affect game behavior nor moderate the association between psychopathic traits and prosocial behavior.

Conclusions
Choices on this revised game of prosocial behavior, which can be administered online, are associated with psychopathic traits scores. The game appears to have high immediate test-retest reliability. Exposure to the moral elevation stimulus did not affect prosocial behavior or impact the relationship between psychopathic trait scores and prosocial behavior. Future research should continue to test potential moderators of this relationship. Limitations of the current study are discussed.
Pneumothorax after computed tomography-guided lung biopsy: Utility of immediate post-procedure computed tomography and one-hour delayed chest radiography
Authors: Weinand Jared Thomas , du Pisanie Lourens , Ngeve Smith , Commander Clayton , Yu Hyeon 
Published: April 2023

Purpose
To evaluate the utility of immediate post-procedure computed tomography (IPP-CT) and routine one-hour chest radiography (1HR-CXR) for detecting and managing pneumothorax in patients undergoing computed tomography (CT)-guided percutaneous lung biopsy.

Materials and methods
All CT-guided percutaneous lung biopsies performed between May 2014 and August 2021 at a single institution were included. Data from 275 procedures performed on 267 patients (147 men; mean age: 63.5 ± 14.1 years; range 18–91 years) who underwent routine 1HR-CXR were reviewed. Incidences of pneumothorax and procedure-related complications on IPP-CT and 1HR-CXR were recorded. Associated variables, including tract embolization methods, needle diameter/type, access site, lesion size, needle tract distance, and number of biopsy samples obtained were analyzed and compared between groups with and without pneumothorax.

Results
Post-procedure complications included pneumothorax (30.9%, 85/275) and hemoptysis (0.7%, 2/275). Pneumothorax was detected on IPP-CT and 1HR-CXR in 89.4% (76/85) and 100% (85/85), respectively. A chest tube was placed in 4% (11/275) of the cases. In 3.3% (9/275) of the cases, delayed pneumothorax was detected only on 1HR-CXR, but no patient in this group necessitated chest tube placement. The incidence of pneumothorax was not significantly different between tract embolization methods (p = 0.36), needle diameters (p = 0.36) and types (p = 0.33), access sites (p = 0.07), and lesion sizes (p = 0.88). On logistic regression, a lower biopsy sample number (OR = 0.49) was a protective factor, but a longer needle tract distance (OR = 1.16) was a significant risk factor for pneumothorax.

Conclusion
Following CT-guided percutaneous lung biopsy, pneumothorax detected on IPP-CT strongly indicates persistent pneumothorax on 1HR-CXR and possible chest tube placement. If no pneumothorax is identified on IPP-CT, follow-up 1HR-CXR may be required only for those who develop symptoms of pneumothorax.
High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro
Authors: Bouck Emma G. , Arvanitis Marios , Osburn William O. , Sang Yaqiu , Reventun Paula , Ahmadzia Homa K. , Smith Nicholas L. , Lowenstein Charles J. , Wolberg Alisa S. 
Published: April 2023

BackgroundOral contraceptive (OC) use increases venous thromboembolism risk 2-5-fold. Procoagulant changes can be detected in plasma from OC users even without thrombosis, but cellular mechanisms that provoke thrombosis have not been identified. Endothelial cell (EC) dysfunction is thought to initiate venous thromboembolism. It is unknown whether OC hormones provoke aberrant procoagulant activity in ECs.ObjectiveCharacterize the effect of high-risk OC hormones (ethinyl estradiol [EE] and drospirenone) on EC procoagulant activity and the potential interplay with nuclear estrogen receptors ERα and ERβ and inflammatory processes.MethodsHuman umbilical vein and dermal microvascular ECs (HUVEC and HDMVEC, respectively) were treated with EE and/or drospirenone. Genes encoding the estrogen receptors ERα and ERβ (ESR1andESR2, respectively) were overexpressed in HUVEC and HDMVEC via lentiviral vectors. EC gene expression was assessed by RT-qPCR. The ability of ECs to support thrombin generation and fibrin formation was measured by calibrated automated thrombography and spectrophotometry, respectively.ResultsNeither EE nor drospirenone, alone or together, changed expression of genes encoding anti- or procoagulant proteins (TFPI,THBD,F3), integrins (ITGAV,ITGB3), or fibrinolytic mediators (SERPINE1,PLAT). EE and/or drospirenone did not increase EC-supported thrombin generation or fibrin formation, either. Our analyses indicated a subset of individuals expressESR1andESR2transcripts in human aortic ECs. However, overexpression ofESR1and/orESR2in HUVEC and HDMVEC did not facilitate the ability of OC-treated ECs to support procoagulant activity, even in the presence of a pro-inflammatory stimulus.ConclusionsThe OC hormones EE and drospirenone do not directly enhance thrombin generation potential of primary ECsin vitro.
Eating habits and lifestyle behaviors during COVID-19 lockdown: The Lebanese experience
Authors: Haidar Suzan , Cherfan Michelle , Hallit Souheil , Rahal Mohamad , Safwan Jihan 
Published: April 2023

Objectives
This study aimed to assess dietary intake and lifestyle habits followed during the COVID-19 pandemic and subsequent lockdowns, as well as the level of adherence to the Mediterranean diet (MD), among a sample of the Lebanese population.

Methods
A cross-sectional study was conducted during the government-enforced lockdown. A validated, online, questionnaire was used to collect information about dietary and lifestyle habits. The Mediterranean diet adherence screener (MEDAS) was used to assess adherence to the MD.

Results
A total of 1684 participants responded to the survey. Their mean age was 23.92 ± 7.62 years, and 70.4% were females. Approximately a third of the participants reported that their dietary habits did not change and 42.3% acknowledged that their eating habits deteriorated during the lockdown. Participants smoked less and slept more during the lockdown compared to before it. Approximately 19.2% of the sample reported low adherence to the MD whereas 63.9% and 16.9% described moderate and high adherence respectively. Only age was significantly associated with higher MD adherence.

Conclusion
Dietary intake and MD adherence were suboptimal during the COVID-19 lockdown among the sample of the Lebanese population. It is critical that the Lebanese government implements public health programs in order to promote awareness about the importance of adhering to a healthy lifestyle and making appropriate dietary and lifestyle choices.
Video triage of children with respiratory symptoms at a medical helpline is safe and feasible–a prospective quality improvement study
Authors: Gren Caroline , Hasselager Asbjoern Boerch , Linderoth Gitte , Frederiksen Marianne Sjølin , Folke Fredrik , Ersbøll Annette Kjær , Gamst-Jensen Hejdi , Cortes Dina 
Published: April 2023

BackgroundYoung children are among the most frequent patients at medical call centers, even though they are rarely severely ill. Respiratory tract symptoms are among the most prevalent reasons for contact in pediatric calls. Triage of children without visual cues and through second-hand information is perceived as difficult, with risks of over- and under-triage.ObjectiveTo study the safety and feasibility of introducing video triage of young children with respiratory symptoms at the medical helpline 1813 (MH1813) in Copenhagen, Denmark, as well as impact on patient outcome.MethodsProspective quality improvement study including 617 patients enrolled to video or standard telephone triage (1:1) from February 2019-March 2020. Data originated from MH1813 patient records, survey responses, and hospital charts. Primary outcome was difference in patients staying at home eight hours after the call. Secondary outcomes weas hospital outcome, feasibility and acceptability. Adverse events (intensive care unit admittance, lasting injuries, death) were registered. Logistic regression was used to test the effect on outcomes. The COVID-19 pandemic shut the study down prematurely.ResultsIn total, 54% of the included patients were video-triaged., and 63% of video triaged patients and 58% of telephone triaged patients were triaged to stay at home, (p = 0.19). Within eight and 24 hours, there was a tendency of fewer video-triaged patients being assessed at hospitals: 39% versus 46% (p = 0.07) and 41% versus 49% (p = 0.07), respectively. At 24 hours after the call, 2.8% of the patients were hospitalized for at least 12 hours. Video triage was highly feasible and acceptable (>90%) and no adverse events were registered.ConclusionVideo triage of young children with respiratory symptoms at a medical call center was safe and feasible. Only about 3% of all children needed hospitalization for at least 12 hours. Video triage may optimize hospital referrals and increase health care accessibility.
Economic and Environmental Conditions for the Diffusion of Insurance in Three Non-Euro-American Regions During the Nineteenth and Twentieth Centuries
Authors: Pearson Robin , Daudi Francis , Kocher Eva , Musterle Claus 
Published: April 2023

Abstract
This paper discusses the macroeconomic and environmental conditions for the spread of insurance in three non-Western world regions (China, Middle East and sub-Sahara Africa). Focusing on the nineteenth and twentieth centuries, it examines the patterns of economic development relevant for the growth of insurance in these regions, and compares these against standard economic models of insurance diffusion. The paper argues that the growth of insurance must be explained by more than a simple linear relationship with the growth of per capita incomes. As well as income levels, other factors affecting insurance development include urbanization, taxation, savings rates, legal compulsion to insure, state provision of social security, state-owned insurance bodies and the presence of large infrastructural projects. The second part of the paper focuses on environmental conditions in these regions that drove insurance growth, including climate and geography, demography, drought and disease, building materials and risk-reduction technologies.
Stable pair compactification of moduli of K3 surfaces of degree 2
Authors: Alexeev Valery , Engel Philip , Thompson Alan 
Published: April 2023

Abstract
We prove that the universal family of polarized K3 surfaces of degree 2 can be extended to a flat family of stable KSBA pairs

(
X
,

ϵ
⁢
R

)

(X,\epsilon R)

over the toroidal compactification associated to the Coxeter fan.
One-parameter degenerations of K3 surfaces in this family are described by integral-affine structures on a sphere with 24 singularities.
Automatic Exercise Generation for Exploring Connections between Mathematics and Music
Authors: Brito Irene , Almeida José João , Machado Gaspar J. 
Published: April 2023

Abstract
Mathematics and Music are closely connected and their multifaceted relationship has been explored since ancient times. Pythagoras was one of the first who discovered and formalized one of those connections by studying the arithmetic of musical intervals, expressing them by numerical ratios and relating ratios to consonance/dissonance notions, being the Pythagorean tuning and scale based on arithmetic principles. Another interesting link between Mathematics and Music is the geometric approach to musical composition. Geometric patterns are present in different musical style compositions and some composing techniques, such as the 12-tone technique, use geometric transformations, involving also applications of modular arithmetic and set theory to Music. The aim of this work is to present existing relations between Mathematics and Music and to propose automatic exercise generation for exploring and studying those relations. The exercises are generated using the system MVGEN and the LaTeX package MusiXTeX. The generation process and the automatically generated exercises can be used for creating learning and assessment materials for education in Mathematics and Music, linking Science and Art.
Study on the Early Cretaceous fluvial-desert sedimentary paleogeography in the Northwest of Ordos Basin
Authors: Feng Yangwei , Ren Yan , Xia Fei , Jiang Ting , Lu Fengxian , Guo Jiazeng 
Published: April 2023

Abstract
Early Cretaceous desert sedimentary system was developed in Northwest Ordos Basin. At present, the research degree of desert sedimentary paleogeography is low. The research on paleogeographic environment of Early Cretaceous sedimentary sandstone has guiding significance for the exploration of uranium resource and underground water resource in Northwest Ordos Basin. Based on the previous basic geological data of the lower Cretaceous in the Northwest of Ordos, through field geological survey, drilling core observation, and paleocurrent measurement, the sedimentary paleogeographic environments in different periods of Early Cretaceous had been studied. The results show that the lower Cretaceous in Northwestern Ordos Basin can be divided into two sedimentary cycles, the lower sedimentary cycle composed of Luohe Formation and Huachi-Huanhe Formation, and the upper sedimentary cycle composed of Luohandong Formation and Jingchuan Formation. Alluvial, Aeolian, and desert lake depositional systems were developed. The main sedimentary facies were alluvial fan, braided river, sand dune, dry valley, and dry lake. Alluvial fan and braided river facies had mainly developed in Luohe Formation. Braided fluvial facies mainly had developed in Huachi-Huanhe Formation, and alluvial fans locally developed around it. The deposits in Luohandong Formation were mainly aeolian sandstone, and the alluvial fan facies were inherently developed at Western and Northern margins. The depositional environment of Jingchuan formation is mainly river and lake. The tectonic evolution of lower Cretaceous had controlled the development of paleogeographic environment, and sedimentary facies had controlled the development of aquifer system. The paleogeographic environment of Early Cretaceous is conducive to the reduction and enrichment of uranium and the development of metallogenic units.
Recovery of critical metals from carbonatite-type mineral wastes: Geochemical modeling investigation of (bio)hydrometallurgical leaching of REEs
Authors: Odimba Nneka Joyce , Khalidy Reza , Bakhshoodeh Reza , Santos Rafael M. 
Published: April 2023

Abstract
Rare earth elements (REEs) are typically found in low concentrations within natural rocks that make up mine tailings, such as carbonates in association with silicates within carbonatite igneous rocks, so it is of interest to develop (bio)hydrometallurgical ways to liberate them from the silicate matrix. This work investigated, through geochemical modeling, the extraction of europium and ytterbium carbonates from rocks containing one of four silicates (chrysotile, forsterite, montmorillonite, and phlogopite) via chemical (mineral acid) or biological (organic acid) leaching. The results indicated conditions that led to either congruent or incongruent dissolution of the mineral phases and the formation of transient mineral phases. Chemical leaching models suggest that REE carbonates are recoverable in one-step leaching from forsterite and chrysotile rocks, while they are recoverable in a secondary leaching step from montmorillonite and phlogopite rocks. Gibbsite as a transient phase is shown to complicate REE recovery, potentially requiring reactive extraction. REEs have the potential to be recovered from silicate rocks via chemoorganotrophic bioleaching, but the process configuration would differ depending on the predominant minerals that make up the rock, and the type of REE present in it.
Personalized decision making – A conceptual introduction
Authors: Mueller Scott , Pearl Judea 
Published: April 2023

Abstract
Personalized decision making targets the behavior of a specific individual, while population-based decision making concerns a subpopulation resembling that individual. This article clarifies the distinction between the two and explains why the former leads to more informed decisions. We further show that by combining experimental and observational studies, we can obtain valuable information about individual behavior and, consequently, improve decisions over those obtained from experimental studies alone. In particular, we show examples where such a combination discriminates between individuals who can benefit from a treatment and those who cannot – information that would not be revealed by experimental studies alone. We outline areas where this method could be of benefit to both policy makers and individuals involved.