bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal treatments and outcome measures of palmoplantar pustulosis: A systematic review and network meta‐analysis‐based comparison of treatment efficacy
Authors: Fukasawa Takemichi , Yamashita Takashi , Enomoto Atsushi , Yoshizaki‐Ogawa Asako , Miyagawa Kiyoshi , Sato Shinichi , Yoshizaki Ayumi 
Published: September 2023

AbstractFew studies have made direct comparisons between treatments for palmoplantar pustulosis (PPP); therefore, it is difficult to select the best treatment for each patient. To determine the best therapy and to compare reported measures of efficacy in clinical trials of systemic treatments for PPP in this systematic review and network meta‐analysis. Six databases were used to perform database search on 10 July 2022. Randomized controlled trials (RCTs) were identified through a systematic literature search. The titles and abstracts of articles were initially screened for inclusion by two authors independently using our predetermined criteria. The full texts of selected articles were then independently assessed for inclusion in a blinded fashion. Disagreement between the authors was resolved by consensus. Data were abstracted in duplicate. Random‐effects model was accepted to perform network meta‐analysis. Assessed Grading of Recommendations Assessment, Development and Evaluation certainty of evidence were performed according to the PRISMA guidelines. The analysis was completed in July 2022. The primary outcome was the change of PPP Area and Severity Index (PPPASI) from baseline and the secondary outcome was the achievement of PPPASI‐50 response. Seven RCTs with 567 patients were included. Guselkumab 100 mg was the one with the highest probability of reaching the proposed outcomes (mean difference [MD], −8.00; 95% confidence interval [CI], 4.88–11.11), while the achievement of PPPASI‐50 response did not show a significant difference (odds ratio [OR], 3.79; 95% CI, 0.51–28.37). Guselkumab 200 mg was next to 100 mg of reaching the proposed outcomes (MD, −4.71; 95% CI, 2.12–7.30), while the achievement of PPPASI‐50 response did not show a significant difference (OR, 2.34; 95% CI, 0.48–11.43). Network meta‐analysis showed guselkumab 100 mg was the treatment with the highest probability of reaching both PPPASI and PPPASI‐50 outcomes. Absolute PPPASI may be more appropriate as an outcome than PPPASI‐50.
Brain‐derived neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A
Authors: Swain Maryann , K. Soman Smijin , Tapia Kylea , Dagda Raul Y. , Dagda Ruben K. 
Published: September 2023

AbstractBrain‐derived neurotrophic factor (BDNF) stimulates dendrite outgrowth and synaptic plasticity by activating downstream protein kinase A (PKA) signaling. Recently, BDNF has been shown to modulate mitochondrial respiration in isolated brain mitochondria, suggesting that BDNF can modulate mitochondrial physiology. However, the molecular mechanisms by which BDNF stimulates mitochondrial function in neurons remain to be elucidated. In this study, we surmised that BDNF binds to the TrkB receptor and translocates to mitochondria to govern mitochondrial physiology in a PKA‐dependent manner. Confocal microscopy and biochemical subcellular fractionation assays confirm the localization of the TrkB receptor in mitochondria. The translocation of the TrkB receptor to mitochondria was significantly enhanced upon treating primary cortical neurons with exogenous BDNF, leading to rapid PKA activation. Showing a direct role of BDNF in regulating mitochondrial structure/function, time‐lapse confocal microscopy in primary cortical neurons showed that exogenous BDNF enhances mitochondrial fusion, anterograde mitochondrial trafficking, and mitochondrial content within dendrites, which led to increased basal and ATP‐linked mitochondrial respiration and glycolysis as assessed by an XF24e metabolic analyzer. BDNF‐mediated regulation of mitochondrial structure/function requires PKA activity as treating primary cortical neurons with a pharmacological inhibitor of PKA or transiently expressing constructs that target an inhibitor peptide of PKA (PKI) to the mitochondrion abrogated BDNF‐mediated mitochondrial fusion and trafficking. Mechanistically, western/Phos‐tag blots show that BDNF stimulates PKA‐mediated phosphorylation of Drp1 and Miro‐2 to promote mitochondrial fusion and elevate mitochondrial content in dendrites, respectively. Effects of BDNF on mitochondrial function were associated with increased resistance of neurons to oxidative stress and dendrite retraction induced by rotenone. Overall, this study revealed new mechanisms of BDNF‐mediated neuroprotection, which entails enhancing mitochondrial health and function of neurons.image
Quantitative anatomy of the large variant right hepatic vein: A systematic three‐dimensional analysis
Authors: Lin Jinyu , Tao Haisu , Wang Junfeng , Li Xinci , Wang Zhuangxiong , Fang Chihua , Yang Jian 
Published: September 2023

AbstractAnatomical variations of the right hepatic vein, especially large variant right hepatic veins (≥5 mm), have important clinical implications in liver transplantation and resection. This study aimed to evaluate anatomical variations of the right hepatic vein using quantitative three‐dimensional visualization analysis. Computed tomography images of 650 patients were retrospectively analyzed, and three‐dimensional visualization was applied using the derived data to analyze large variant right hepatic veins. The proportion of the large variant right hepatic vein was 16.92% (110/650). According to the location and number of the variant right hepatic veins, the configuration of the right hepatic venous system was divided into seven subtypes. The length of the retrohepatic inferior vena cava had a positive correlation with the diameter of the right hepatic vein (rs = 0.266, p = 0.001) and the variant right hepatic veins (rs = 0.211, p = 0.027). The diameter of the right hepatic vein was positively correlated with that of the middle hepatic vein (rs = 0.361, p < 0.001), while it was inversely correlated with that of the variant right hepatic veins (rs = −0.267, p = 0.005). The right hepatic vein diameter was positively correlated with the drainage volume (rs = 0.489, p < 0.001), while the correlation with the variant right hepatic veins drainage volume was negative (rs = −0.460, p < 0.001). The number of the variant right hepatic veins and their relative diameters were positively correlated (p < 0.001). The volume and percentage of the drainage area of the right hepatic vein decreased significantly as the number of the variant right hepatic vein increased (p < 0.001). The findings of this study concerning the variations of the hepatic venous system may be useful for the surgical planning of liver resection or transplantation.
Productive and repressive power: The influence of gender norms on parents' decisions on children's consumption
Authors: Lopes Lealis Vaz Meleiro , Veloso Andres Rodriguez , Ferraz Sofia Batista 
Published: September 2023

AbstractThis study examines how parents exert productive and repressive power in influencing their children's gender socialization through consumption. We interviewed 20 parents responsible for educating 36 children to investigate their challenges when confronted with their children's consumption demands that deviate from gender‐appropriate norms. Under a queer feminist poststructuralist perspective, our results reveal the conflicts between parents and their children and between mothers and fathers when making consumption decisions that affect gender socialization. Our findings contribute to the consumer socialization literature by recognizing how gender norms influence parents' decisions about their children's consumption. We also shed light on the deployment of productive and repressive power tactics by parents in shaping their children's gender identity toward an “ideal” norm.
Daily strengths use and work performance: A self‐determination perspective
Authors: Moore Hannah L. , Bakker Arnold B. , van Mierlo Heleen , van Woerkom Marianne 
Published: September 2023

AbstractDrawing on self‐determination theory, this study examines how using personal strengths at work in the morning is associated with different types of performance throughout the workday. Momentary satisfaction of the needs for autonomy, relatedness and competence are proposed as mechanisms that differentially link strengths use to four different performance outcomes: task accomplishment, goal attainment, organizational citizenship behaviour and counterproductive work behaviour. We collected data from 216 Dutch employees in a large variety of sectors twice a day for one workweek (N = 1470 observations) using a smartphone application. Results of multilevel structural equation modelling showed that momentary satisfaction of the needs for autonomy and competence at noon mediated the positive relationship between morning strengths use and afternoon task accomplishment and goal attainment. Furthermore, satisfaction of the need for relatedness mediated the positive relationship between morning strengths use and afternoon organizational citizenship behaviour, but not the negative relationship between morning strengths use and counterproductive work behaviour. These findings deepen our understanding of strengths use theory and uncover novel insight on the temporal aspects of strengths use within a working day.
Secondary bruxism: A valid diagnosis or just a coincidental finding of additional masticatory muscle activity? A narrative review of literature
Authors: Conti Paulo Cesar R. , Cunha Carolina Ortigosa , Conti Ana Cláudia de Castro F. , Bonjardim Leonardo R. , Barbosa Juliana Stuginski , Costa Yuri Martins 
Published: September 2023

AbstractIntroductionBruxism is defined as a repetitive masticatory muscle activity that can manifest it upon awakening (awake bruxism‐AB) or during sleep (sleep bruxism‐SB). Some forms of both, AB and SB can be associated to many other coexistent factors, considered of risk for the initiation and maintenance of the bruxism. Although controversial, the term ‘secondary bruxism’ has frequently been used to label these cases. The absence of an adequate definition of bruxism, the non‐distinction between the circadian manifestations and the report of many different measurement techniques, however, are important factors to be considered when judging the literature findings. The use (and abuse) of drugs, caffeine, nicotine, alcohol and psychoactive substances, the presence of respiratory disorders during sleep, gastroesophageal reflux disorders and movement, neurological and psychiatric disorders are among these factors. The scarcity of controlled studies and the complexity and interactions among all aforementioned factors, unfortunately, does not allow to establish any causality or temporal association with SB and AB. The supposition that variables are related depends on different parameters, not clearly demonstrated in the available studies.ObjectivesThis narrative review aims at providing oral health care professionals with an update on the co‐risk factors and disorders possibly associated with bruxism. In addition, the authors discuss the appropriateness of the term ‘secondary bruxism’ as a valid diagnostic category based on the available evidence.ConclusionThe absence of an adequate definition of bruxism, the non‐distinction between the circadian manifestations and the report of many different measurement techniques found in many studies preclude any solid and convincing conclusion on the existence of the ‘secondary’ bruxism.
Effect of different digital technology on the adaptation and retention of Co‐Cr partial denture frameworks
Authors: Heiba Islam Mohamed , Mohamed Lotfy Shaimaa , Rizk Fardos Nabil , Sabet Marwa Ezzat 
Published: September 2023

AbstractPurposeTo evaluate the overall adaptation and retention of class I cobalt‐chromium (Co‐Cr) removable partial denture (RPD) frameworks using three different computer‐aided design and computer‐aided manufacturing (CAD‐CAM) technologies: Indirect wax milling with lost wax technique (LWT), direct milling, and selective laser melting (SLM) technique.Materials and MethodsAn educational maxillary stone model (Kennedy class I) was scanned after preparing rest seats to create a resin model. The resin model was scanned, and the RPD framework was digitally designed and saved as a standard tessellation language (STL) file. Twenty‐four Co‐Cr RPD frameworks were then constructed and divided into three groups (n = 8) based on fabrication technique: Group A (indirect wax milling with LWT), Group B (direct milling), and Group C (selective laser melting). In Group A, the STL file was used to mill the design from castable resin blanks which were then cast by the LWT. In Group B, the STL file was used to mill the design from the Co‐Cr blank directly. Finally in Group C, the STL file was used to print the design from Co‐Cr powder using SLM 3D printed technique. Geomagic Control X software was used to measure the overall adaptation of the fabricated RPD frameworks, Retention was also tested using a universal testing machine. One‐way Analysis of Variance (ANOVA) test was used to compare the three groups then the Tukey HSD post‐hoc test was used for pair‐wise comparisons. The significance level was set at p ≤ 0.05.ResultsRegarding the overall adaptation, Group B (0.71 ± 0.02 mm) showed significantly higher adaptation than Group A (0.96 ± 0.06 mm) and Group C (1.05 ± 0.16 mm). Regarding retention, Group B (2.03 ± 0.34 N) showed significantly higher retention than Group A (1.00 ± 0.13 N) and Group C (0.78 ±0.17 N).ConclusionBased on the findings of this in vitro study, Co‐Cr RPD frameworks fabricated by direct milling technique revealed the best adaptation and retention.
Cortical hyperarousal in individuals with frequent nightmares
Authors: Sayk Clara , Saftien Sophia , Koch Nicole , Ngo Hong‐Viet V. , Junghanns Klaus , Wilhelm Ines 
Published: September 2023

SummaryNightmares are common among the general population and psychiatric patients and have been associated with signs of nocturnal arousal such as increased heart rate or increased high‐frequency electroencephalographic (EEG) activity. However, it is still unclear, whether these characteristics are more of a trait occurring in people with frequent nightmares or rather indicators of the nightmare state. We compared participants with frequent nightmares (NM group; n = 30) and healthy controls (controls; n = 27) who spent 4 nights in the sleep laboratory over the course of 8 weeks. The NM group received six sessions of imagery rehearsal therapy (IRT), the ‘gold standard’ of cognitive‐behavioural therapy for nightmares, between the second and the third night. Sleep architecture and spectral power were compared between groups, and between nights of nightmare occurrence and nights without nightmare occurrence in the NM group. Additionally, changes before and after therapy were recorded. The NM group showed increased beta (16.25–31 Hz) and low gamma (31.25–35 Hz) power during the entire night compared to the controls, but not when comparing nights of nightmare occurrence to those without. Moreover, low gamma activity in rapid eye movement sleep was reduced after therapy in the NM group. Our findings indicate, cortical hyperarousal is more of a trait in people with frequent nightmares within a network of other symptoms, but also malleable by therapy. This is not only a new finding for IRT but could also lead to improved treatment options in the future that directly target high‐frequency EEG activity.
Bronchial collapse and bronchial stenting in 9 dogs
Authors: Kelly Darren , Juvet Florence , Lamb Valerie , Holdsworth Andrew 
Published: September 2023

AbstractBackgroundPrincipal and lobar bronchial collapse is increasingly recognized as an isolated entity.ObjectiveRetrospectively describe the procedure and outcomes of dogs undergoing bronchial stenting at a single referral hospital.AnimalsNine client‐owned dogs with variable degrees of collapse of the left principal bronchus (LPB), lobar bronchus 1 (LB1), and lobar bronchus 2 (LB2), and with clinically relevant signs of respiratory dysfunction.MethodsData were collected from patient records. All dogs underwent stenting of the LPB and LB2. Anatomic and functional impairment grades were assigned to each case before and 4 weeks after stenting. Data regarding response to stenting and complications were evaluated.ResultsBronchial stenting was considered successful in all cases, with all dogs experiencing improved quality of life (QOL), and decreased functional impairment grade at 4 weeks post‐stenting. Follow‐up of >6 months was available for 6 dogs and of these, 5 were alive at 12 months, 3 were alive at 18 months, and 1 was alive at 24 months. Stent‐related complications occurred in 4 dogs, and were resolvable in 3. Two dogs developed pneumothorax, 1 developed recurrent pneumonia, and 1 developed new‐onset coughing. All dogs had mild and manageable coughing post‐stenting.Conclusions and Clinical ImportanceStenting of the LBP and LB2 might be an effective option for dogs with advanced collapse of these bronchi and associated signs. Although all included dogs had resolution or improvement of clinical signs considered life‐threatening or as affecting QOL, ongoing coughing is expected. Patient selection appears important with regard to achieving successful outcomes.
Evidence of introgression, ecological divergence and adaptation inAsteriassea stars
Authors: Giakoumis Melina , Pinilla‐Buitrago Gonzalo E. , Musher Lukas J. , Wares John P. , Baird Stuart J. E. , Hickerson Michael J. 
Published: September 2023

AbstractHybrid zones are important windows into the evolutionary dynamics of populations, revealing how processes like introgression and adaptation structure population genomic variation. Importantly, they are useful for understanding speciation and how species respond to their environments. Here, we investigate two closely related sea star species,Asterias rubensandA. forbesi, distributed along rocky European and North American coastlines of the North Atlantic, and use genome‐wide molecular markers to infer the distribution of genomic variation within and between species in this group. Using genomic data and environmental niche modelling, we document hybridization occurring between northern New England and the southern Canadian Maritimes. We investigate the factors that maintain this hybrid zone, as well as the environmental variables that putatively drive selection within and between species. We find that the two species differ in their environmental niche breadth;Asterias forbesidisplays a relatively narrow environmental niche while conversely,A. rubenshas a wider niche breadth. Species distribution models accurately predict hybrids to occur within environmental niche overlap, thereby suggesting environmental selection plays an important role in the maintenance of the hybrid zone. Our results imply that the distribution of genomic variation in North Atlantic sea stars is influenced by the environment, which will be crucial to consider as the climate changes.
Estimation of shear stress heterogeneity along capillary segments in angiogenic rat mesenteric microvascular networks
Authors: Hu Nien‐Wen , Lomel Banks M. , Rice Elijah W. , Hossain Mir Md Nasim , Sarntinoranont Malisa , Secomb Timothy W. , Murfee Walter L. , Balogh Peter 
Published: September 2023

AbstractObjectiveFluid shear stress is thought to be a regulator of endothelial cell behavior during angiogenesis. The link, however, requires an understanding of stress values at the capillary level in angiogenic microvascular networks. Critical questions remain. What are the stresses? Do capillaries experience similar stress magnitudes? Can variations explain vessel‐specific behavior? The objective of this study was to estimate segment‐specific shear stresses in angiogenic networks.MethodsImages of angiogenic networks characterized by increased vascular density were obtained from rat mesenteric tissues stimulated by compound 48/80‐induced mast cell degranulation. Vessels were identified by perfusion of a 40 kDa fixable dextran prior to harvesting and immunolabeling for PECAM. Using a network flow‐based segment model with physiologically relevant parameters, stresses were computed per vessel for regions across multiple networks.ResultsStresses ranged from 0.003 to 2328.1 dyne/cm2 and varied dramatically at the capillary level. For all regions, the maximum segmental shear stresses were for capillary segments. Stresses along proximal capillaries branching from arteriole inlets were increased compared to stresses along capillaries in more distal regions.ConclusionsThe results highlight the variability of shear stresses along angiogenic capillaries and motivate new discussions on how endothelial cells may respond in vivo to segment‐specific microenvironment during angiogenesis.
The AP2/ERF transcription factor PtoERF15 confers drought tolerance via JA‐mediated signaling in Populus
Authors: Kong Lingfei , Song Qin , Wei Hongbin , Wang Yanhong , Lin Minghui , Sun Kuan , Zhang Yuqian , Yang Jiarui , Li Chaofeng , Luo Keming 
Published: September 2023

Summary

Drought stress is one of the major limiting factors for the growth and development of perennial trees. Xylem vessels act as the center of water conduction in woody species, but the underlying mechanism of its development and morphogenesis under water‐deficient conditions remains elucidation.

Here, we identified and characterized an osmotic stress‐induced ETHYLENE RESPONSE FACTOR 15 (PtoERF15) and its target, PtoMYC2b, which was involved in mediating vessel size, density, and cell wall thickness in response to drought in Populus tomentosa.

PtoERF15 is preferentially expressed in differentiating xylem of poplar stems. Overexpression of PtoERF15 contributed to stem water potential maintaining, thus promoting drought tolerance. RNA‐Seq and biochemical analysis further revealed that PtoERF15 directly regulated PtoMYC2b, encoding a switch of JA signaling pathway. Additionally, our findings verify that three sets of homologous genes from NAC (NAM, ATAF1/2, and CUC2) gene family: PtoSND1‐A1/A2, PtoVND7‐1/7‐2, and PtoNAC118/120, as the targets of PtoMYC2b, are involved in the regulation of vessel morphology in poplar.

Collectively, our study provides molecular evidence for the involvement of the PtoERF15‐PtoMYC2b transcription cascade in maintaining stem water potential through the regulation of xylem vessel development, ultimately improving drought tolerance in poplar.