bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUOH 03 Guidewire for the Management of Coronary Artery Dissection: Insights from a Multicenter Registry
Authors: Gasparini Gabriele L. , Bollati Mario , Chiarito Mauro , Cacia Michele , Roccasalva Fausto , Ungureanu Claudiu , Colletti Giuseppe , Muraglia Simone , Merella Pierluigi , Ugo Fabrizio , Pacchioni Andrea , Colangelo Salvatore , Sanz Sanchez Jorge , Leone Pier Pasquale , Latib Azeem , Mazzarotto Pietro 
Published: August 2023

Background. In the setting of coronary artery dissection, both spontaneous and iatrogenic, fixing the intimal tear, usually with stent implantation, can be extremely challenging if the distal wire position has been lost. Common complications are mainly related to the inadvertent subintimal tracking of the guidewire while attempting to gain the distal true lumen. Aims. To report the registry results of using the SUOH 0.3 guidewire for managing coronary artery dissection in a real-world multicenter setting. Methods. The study population in this retrospective, multicenter, international registry included 75 consecutive patients who underwent PCI and required an antegrade wiring of a dissected coronary artery. Results. Successful use of SUOH 0.3 was achieved in 69 (92%) patients. The use of a microcatheter was associated with a significantly higher rate of TIMI 3 flow at the end of the procedure (no microcatheter: n = 17, 81%; microcatheter: n = 52, 96.3%;

p

= 0.017). The first recanalization attempt was made with the SUOH 03 guidewire in 48 (64%) cases, and it was successful in 42 (87%). The overall PCI success rate was reported in 72 (96%) patients, with no significant differences among patients with different origins, mechanisms, and locations of dissection. Conclusions. In this setting, the SUOH 0.3 guidewire provides high procedural success without additional complex techniques.
Genome-Scale Methylation Analysis Identifies Immune Profiles and Age Acceleration Associations with Bladder Cancer Outcomes
Authors: Chen Ji-Qing , Salas Lucas A. , Wiencke John K. , Koestler Devin C. , Molinaro Annette M. , Andrew Angeline S. , Seigne John D. , Karagas Margaret R. , Kelsey Karl T. , Christensen Brock C. 
Published: August 2023

Abstract

Background:
Immune profiles have been associated with bladder cancer outcomes and may have clinical applications for prognosis. However, associations of detailed immune cell subtypes with patient outcomes remain underexplored and may contribute crucial prognostic information for better managing bladder cancer recurrence and survival.

Methods:
Bladder cancer case peripheral blood DNA methylation was measured using the Illumina HumanMethylationEPIC array. Extended cell-type deconvolution quantified 12 immune cell-type proportions, including memory, naïve T and B cells, and granulocyte subtypes. DNA methylation clocks determined biological age. Cox proportional hazards models tested associations of immune cell profiles and age acceleration with bladder cancer outcomes. The partDSA algorithm discriminated 10-year overall survival groups from clinical variables and immune cell profiles, and a semi-supervised recursively partitioned mixture model (SS-RPMM) with DNA methylation data was applied to identify a classifier for 10-year overall survival.

Results:
Higher CD8T memory cell proportions were associated with better overall survival [HR = 0.95, 95% confidence interval (CI) = 0.93–0.98], while higher neutrophil-to-lymphocyte ratio (HR = 1.36, 95% CI = 1.23–1.50), CD8T naïve (HR = 1.21, 95% CI = 1.04–1.41), neutrophil (HR = 1.04, 95% CI = 1.03–1.06) proportions, and age acceleration (HR = 1.06, 95% CI = 1.03–1.08) were associated with worse overall survival in patient with bladder cancer. partDSA and SS-RPMM classified five groups of subjects with significant differences in overall survival.

Conclusions:
We identified associations between immune cell subtypes and age acceleration with bladder cancer outcomes.

Impact:
The findings of this study suggest that bladder cancer outcomes are associated with specific methylation-derived immune cell-type proportions and age acceleration, and these factors could be potential prognostic biomarkers.
Analysis of Tumor Microenvironment Changes after Neoadjuvant Chemotherapy with or without Bevacizumab in Advanced Ovarian Cancer (GEICO-89T/MINOVA Study)
Authors: Tavira Beatriz , Iscar Teresa , Manso Luis , Santaballa Ana , Gil-Martin Marta , García García Yolanda , Romeo Margarita , Iglesias Maria , de Juan Ferré Ana , Barretina-Ginesta María Pilar , Manzano Aranzazu , Gaba Lydia , Rubio María Jesús , de Andrea Carlos E. , González-Martín Antonio 
Published: August 2023

Abstract

Purpose:
The aim of our study was to elucidate the impact of bevacizumab added to neoadjuvant chemotherapy (NACT) on the tumor immune microenvironment and correlate the changes with the clinical outcome of the patients.

Experimental Design:
IHC and multiplex immunofluorescence for lymphoid and myeloid lineage markers were performed in matched tumor samples from 23 patients with ovarian cancer enrolled in GEICO 1205/NOVA clinical study before NACT and at the time of interval cytoreductive surgery.

Results:
Our results showed that the addition of bevacizumab to NACT plays a role mainly on lymphoid populations at the stromal compartment, detecting a significant decrease of CD4+ T cells, an increase of CD8+ T cells, and an upregulation in effector/regulatory cell ratio (CD8+/CD4+FOXP3+). None of the changes observed were detected in the intra-epithelial site in any arm (NACT or NACT-bevacizumab). No differences were found in myeloid lineage (macrophage-like). The percentage of Treg populations and effector/regulatory cell ratio in the stroma were the only two variables significantly associated with progression-free survival (PFS).

Conclusions:
The addition of bevacizumab to NACT did not have an impact on PFS in the GEICO 1205 study. However, at the cellular level, changes in CD4+, CD8+ lymphocyte populations, and CD8+/CD4+FOXP3 ratio have been detected only at the stromal site. On the basis of our results, we hypothesize about the existence of mechanisms of resistance that could prevent the trafficking of T-effector cells into the epithelial component of the tumor as a potential explanation for the lack of efficacy of ICI in the first-line treatment of advanced epithelial ovarian cancer.
See related commentary by Soberanis Pina and Oza, p. 12
SETD2 Loss and ATR Inhibition Synergize to Promote cGAS Signaling and Immunotherapy Response in Renal Cell Carcinoma
Authors: Liu Xian-De , Zhang Yan-Ting , McGrail Daniel J. , Zhang Xuesong , Lam Truong , Hoang Anh , Hasanov Elshad , Manyam Ganiraju , Peterson Christine B. , Zhu Haifeng , Kumar Shwetha V. , Akbani Rehan , Pilie Patrick G. , Tannir Nizar M. , Peng Guang , Jonasch Eric 
Published: August 2023

Abstract

Purpose:
Immune checkpoint blockade (ICB) demonstrates durable clinical benefits in a minority of patients with renal cell carcinoma (RCC). We aimed to identify the molecular features that determine the response and develop approaches to enhance it.

Experimental Design:
We investigated the effects of SET domain-containing protein 2 (SETD2) loss on the DNA damage response pathway, the cytosolic DNA-sensing pathway, the tumor immune microenvironment, and the response to ataxia telangiectasia and rad3-related (ATR) and checkpoint inhibition in RCC.

Results:
ATR inhibition activated the cyclic GMP–AMP synthase (cGAS)-interferon regulatory factor 3 (IRF3)–dependent cytosolic DNA-sensing pathway, resulting in the concurrent expression of inflammatory cytokines and immune checkpoints. Among the common RCC genotypes, SETD2 loss is associated with preferential ATR activation and sensitizes cells to ATR inhibition. SETD2 knockdown promoted the cytosolic DNA-sensing pathway in response to ATR inhibition. Treatment with the ATR inhibitor VE822 concurrently upregulated immune cell infiltration and immune checkpoint expression in Setd2 knockdown Renca tumors, providing a rationale for ATR inhibition plus ICB combination therapy. Setd2-deficient Renca tumors demonstrated greater vulnerability to ICB monotherapy or combination therapy with VE822 than Setd2-proficient tumors. Moreover, SETD2 mutations were associated with a higher response rate and prolonged overall survival in patients with ICB-treated RCC but not in patients with non–ICB-treated RCC.

Conclusions:
SETD2 loss and ATR inhibition synergize to promote cGAS signaling and enhance immune cell infiltration, providing a mechanistic rationale for the combination of ATR and checkpoint inhibition in patients with RCC with SETD2 mutations.
Stromal DDR2 Promotes Ovarian Cancer Metastasis through Regulation of Metabolism and Secretion of Extracellular Matrix Proteins
Authors: Schab Angela M. , Greenwade Molly M. , Stock Elizabeth , Lomonosova Elena , Cho Kevin , Grither Whitney R. , Noia Hollie , Wilke Daniel , Mullen Mary M. , Hagemann Andrea R. , Hagemann Ian S. , Thaker Premal H. , Kuroki Lindsay M. , McCourt Carolyn K. , Khabele Dineo , Powell Matthew A. , Mutch David G. , Zhao Peinan , Shriver Leah P. , Patti Gary J. , Longmore Gregory D. , Fuh Katherine C. 
Published: August 2023

Abstract

Ovarian cancer is the leading cause of gynecologic cancer–related deaths. The propensity for metastasis within the peritoneal cavity is a driving factor for the poor outcomes associated with this disease, but there is currently no effective therapy targeting metastasis. In this study, we investigate the contribution of stromal cells to ovarian cancer metastasis and identify normal stromal cell expression of the collagen receptor, discoidin domain receptor 2 (DDR2), that acts to facilitate ovarian cancer metastasis. In vivo, global genetic inactivation of Ddr2 impairs the ability of Ddr2-expressing syngeneic ovarian cancer cells to spread throughout the peritoneal cavity. Specifically, DDR2 expression in mesothelial cells lining the peritoneal cavity facilitates tumor cell attachment and clearance. Subsequently, omentum fibroblast expression of DDR2 promotes tumor cell invasion. Mechanistically, we find DDR2-expressing fibroblasts are more energetically active, such that DDR2 regulates glycolysis through AKT/SNAI1 leading to suppressed fructose-1,6-bisphosphatase and increased hexokinase activity, a key glycolytic enzyme. Upon inhibition of DDR2, we find decreased protein synthesis and secretion. Consequently, when DDR2 is inhibited, there is reduction in secreted extracellular matrix proteins important for metastasis. Specifically, we find that fibroblast DDR2 inhibition leads to decreased secretion of the collagen crosslinker, LOXL2. Adding back LOXL2 to DDR2 deficient fibroblasts rescues the ability of tumor cells to invade. Overall, our results suggest that stromal cell expression of DDR2 is an important mediator of ovarian cancer metastasis.

Implications:
DDR2 is highly expressed by stromal cells in ovarian cancer that can mediate metastasis and is a potential therapeutic target in ovarian cancer.
Christmas in Norwegian Kindergartens: How Are Muslim Children Included?
Authors: Bratsvedal Ine 
Published: July 2023

Abstract
Like the rest of Norwegian society, Norwegian kindergartens are becoming increasingly diverse in terms of religion. This is also reflected in the governing documents of kindergartens, which state that they should work with religion. This article explores to what extent Christmas in kindergartens is adapted to include Muslim children in the group. The article is based on interviews with six kindergarten teachers conducted between 2020 and 2022. Perspectives related to inclusion, freedom of religion, and previous research are used as a starting point to discuss the findings. The article highlights that adaptations of Christmas traditions are largely focused on ensuring that all children have the opportunity to participate in activities without being seen as practicing a specific religion. There is minimal focus on adapting the content to better suit a multireligious group of children.
British Utilitarianism after Bentham: Nineteenth-Century Foundations of International Law Part II
Authors: Schütze Robert 
Published: July 2023

Abstract
What are the legal principles of British utilitarianism in the long nineteenth century; and what conception(s) of international law do they offer? The celebrated founder of the utilitarian school is Jeremy Bentham, who categorically rejects all metaphysical natural law thinking by insisting that all positive law ought to be adopted by a legislature. But in the absence of a world legislature, what did this mean for the positivity and normativity of international law? Surprisingly, Bentham and a second generation of utilitarian thinkers can affirm the legally binding nature of international law; yet with John Austin, a radical ‘sovereigntist’ critique subsequently casts doubt over the nature of international law as law ‘properly so called’. This infamous scepticism would have a profound impact on British international thought in the twentieth century; yet in the nineteenth century, the ideas of a third-generation utilitarian became more prominent: the liberal philosophy of John Stuart Mill. Mill’s ‘relativist’ and ‘civilisational’ conception of international law thereby gave the utilitarian project a specifically imperialist dimension that will be analysed, both in its utilitarian-philosophical and practical-legal dimensions. The article however also explores two other legacies of British utilitarianism, namely: the rise of international codification and the emergence of a specifically British conception of private international law during the nineteenth century.
On Postcolonial Knowledge
Authors: Afolayan Adeshina 
Published: August 2023

Abstract
Knowledge and knowledge production play a significant role in the postcolonial project of de-traumatization and self-realization. However, such knowledge has often been couched within a Eurocentric epistemological framework. The postcolony is caught firmly within the orthodox which translates positivistic knowledge into the very definition of worldly progress—the idea of how a state attends to the welfare and well-being of its citizens through a development agenda. This essay engages the question: What might constitute an autonomous framework that could assist Africa and her thinkers and scholars in the development and validation of local forms of knowledge for social transformation? In this regard, I will examine the claims of Otto Neurath’s postpositivism and the dynamic pluralism of the Ifá sacred corpus of the Yorùbá, both within the framework of the epistemology of the South project. Both of these epistemological frameworks outline a pluralistic understanding of knowledge that could enable the reconfiguring of knowledge production in Africa.
Organ Trafficking in Africa: Pragmatist Ethical Reconsiderations
Authors: Taye Belayneh , Atnafu Abayneh , Endalew Yihenew Wubu , Beyene Sisay Demissew 
Published: July 2023

Abstract
This article focuses on examining the situation of organ trafficking in Africa from the aspect of pragmatist ethics. In the mainstream thought, the broader ethical dilemma of organ trafficking is viewed within the moral contestation of altruism as a rule for organ procurement and the resulting worldwide organ shortage. The incapability of altruistic transplant orthodoxy to serve as an applicable foundation for a public policy is considered as a reason for organ trafficking. In fact, to battle organ trafficking, utilitarian-inclined studies suggest organ selling, compensated donations, and non-directed paid donations as practical alternatives. However, when investigating the context of organ trafficking in Africa, the issue goes beyond the mere moral dilemma of altruism and organ shortage. In the region, organ trafficking is rooted within more systemic, structural, socio-economic, and political problems, grounded in the abuse of transplantation, and connected to transplant tourism and migration, which needs a pragmatic multimodal solutions than the earlier mainstream pathways. In pragmatist ethics, the moral assessment and solutions to the underlying problems depend on the context wherein the moral problem arises. Pragmatist ethics does not stick to absolute moral theories; instead, it focuses on the relevant assessment of the felt moral problem in a given context and aims at seeking solutions afresh. Thus, in the subsequent sections, this article looks at the context of organ trafficking in Africa and reassesses it by incorporating it into the ethical debates of transplantation and organ procurements and trading. The final part of this article reflects on solutions with the reconsideration of the context of transplantation and organ trafficking in the region.
The Irrationality of Inter-vocabulary Change: A Reply to Shields
Authors: Phelan Kate M. 
Published: July 2023

Abstract
The pragmatist rejects the possibility that we can step outside our conceptual scheme in order to assess its correspondence to an unconceptualized reality. Consequently, it seems, she can describe a certain sort of conceptual change, namely, inter-vocabulary change, as rational only retrospectively. In a recent paper, Matthew Shields attempts to show otherwise. He argues that the speaker of such change ought to be understood as performing the speech act of metalinguistic proposal, supposition, or stipulation, and that, thus understood, her utterance is amenable to rational analysis. In this paper, I argue that Shields’ attempt fails. My aim is to show not that we pragmatists remain in search of a solution to this problem but rather that we do not need one.
Media and the Formation of Secular/Religious Networks
Authors: Brinton Jacquelene 
Published: July 2023

Abstract
A recent New York Times op-ed about “Instavangelists” claims these women are replacing traditional religion with their own gospel through Instagram and other online platforms. Christian celebrity pastors also gain success on social media by mimicking the success those media necessitate. Because of these trends the term religion is now networked with elements that make its meaning unstable. Instability comes through experiences that direct understanding in relation to a variety of human activities, which in turn gives religion its meaning. As part of this shift, the social media networking of religion with other elements online in word and image further dilutes the barrier between secular and religious. Whether on affiliated or unaffiliated social media sites, teaching women how to be their best selves is now classified under the shifting category religion, even though both the media and the message further blur the lines between religion and the secular.
900 Years of Trickery: Al-Ḥarīrī From Leiden to Los Angeles
Authors: Cooperson Michael 
Published: July 2023

Abstract
Al-Ḥarīrī’s sixth/twelfth-century story collection (the Maqāmāt, or Impostures) is famous for its rhymes, obscure vocabulary, and complex wordplay. Despite its difficulty, it was used as a text to teach Arabic, a function it continued to serve even after it was introduced to Europe in the seventeenth century CE. After a reverent reception at the hands of early Dutch and English scholars, it was condemned by later French readers as emblematic of “Oriental decadence.” Of the various translations, the most successful are those into Hebrew and German, both of which celebrate the ludic element of the original. The recently published English translation attempts to work from the same principle.
Kazakhstani History Education Considered via Textbooks’ War Narratives, with a Focus on the “Great Patriotic War”
Authors: Satanov Arstan , Ayagan Burkitbay G. , Mussabalina Gulnara 
Published: July 2023

Abstract
The article is devoted to how history is taught in Kazakhstan. We take a concrete example: how the complex history of World War II, a topic that has been highly ideologized in Soviet historiography, is presented in the history textbooks of the post-Soviet period. The study defines how the history of the Great Patriotic War – that is, the Soviet Union’s struggle against the Nazis – has undergone conceptual transformations to varying extents in the textbooks of the countries of the former “socialist camp,” with our focus being Kazakhstan. Additionally, the model of Kazakhstan’s education is essential, as the country has yet to be left out of a definitive history of education narratives. For example, after analyzing history textbooks, it is possible to identify how students’ historical memory about one of the most catastrophic wars has been formed. Our interdisciplinary study used content analysis and “opening up the textbook” to identify types of qualitative models of history textbooks’ content about the war. In addition, the authors analyzed the coverage of the war in textbooks in various historical fields and branches belonging to different stages of Kazakhstan’s educational reforms. One result stood clear, namely that history education has been the subject of frequent debate in Kazakhstan, with the debates indicating how the state apparatus has managed a national approach that teaches a history productive of good patriots. On the other hand, teaching history also has its technocratic justification, as a means for students to acquire necessary skills.
2. Organisational Goals, Strategies, and Digitisation
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar 
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.
Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.
Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.
10. Globally Sustainable Digital Transformation
Authors: Cöster Mathias , Danielson Mats , Ekenberg Love , Gullberg Cecilia , Titlestad Gard , Westelius Alf , Wettergren Gunnar 
Published: August 2023

Whilst digitisation is far from a new concept, many assume that simply introducing automation and information systems in various forms will be enough to make their organisation’s operations more efficient. This misconception can often lead to disarray and costly mistakes. Digital Transformation: Understanding Business Goals, Risks, Processes, and Decisions shows how to avoid such issues via careful consideration of what an enterprise really needs.
Unlike many other books on digital transformation, the authors do not dwell on database design or the details of implementing information systems. Instead, they emphasise the importance of a clear understanding of all aspects of an organisation in order to effectively implement and manage digital systems, from business goals and strategies to structuring information and making decisions, risk assessments, project management, organising, and procuring services and products.
Organised in eleven chapters, and drawing on examples from all over the world, this book will be of interest to university students of business administration, management, information systems, and computer science, as well as practitioners seeking to better understand how to handle digital transformation in their own organisation.