bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parkinson’s disease model in zebrafish using intraperitoneal MPTP injection
Authors: Omar Noor Azzizah , Kumar Jaya , Teoh Seong Lin 
Published: August 2023

IntroductionParkinson’s disease (PD) is the second most common neurodegenerative disease that severely affects the quality of life of patients and their family members. Exposure to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to reflect behavioral, molecular, and proteomic features of PD. This study aimed to assess the protocol for inducing PD following MPTP injection in adult zebrafish.MethodsFish were injected with 100 μg/g of MPTP intraperitoneally once or twice and then assessed on days 1 to 30 post-injection.ResultsBetween one-time and two-time injections, there was no significant difference in most locomotor parameters, expressions of tyrosine hydroxylase-2 (th2) and dopamine transporter (dat) genes, and dopaminergic neurons (tyrosine hydroxylase positive, TH+ cells) counts. However, caspase-3 levels significantly differed between one- and two-time injections on the day 1 assessment.DiscussionOver a 30-day period, the parameters showed significant differences in swimming speed, total distance traveled, tyrosine hydroxylase-1 (th1) and dat gene expressions, caspase-3 and glutathione protein levels, and TH+ cell counts. Days 3 and 5 showed the most changes compared to the control. In conclusion, a one-time injection of MPTP with delayed assessment on days 3 to 5 is a good PD model for animal studies.
Patient-reported outcomes and functional exercise capacity in a real-life setting in non-small cell lung cancer patients undergoing stereotactic body radiotherapy: the Lung PLUS study
Authors: van der Weijst Lotte , Bultijnck Renée , Van Damme Axel , Huybrechts Vincent , van Eijkeren Marc , Lievens Yolande 
Published: August 2023

IntroductionTo better understand the impact of stereotactic body radiotherapy (SBRT) and its treatment-related toxicity on early-stage non-small cell lung cancer (ES-NSCLC) patients, we conducted the Lung PLUS study in a real-world setting.MethodsThis is a monocentric prospective longitudinal study up to 12 months post-treatment, evaluating clinician- and patient-reported toxicity (resp. CTCAE and PRO-CTCAE), health-related quality of life (HRQoL) (EORTC QLQ-C30 and LC-13), activities of daily living (HAQ-DI) and functional exercise capacity (6 Minute Walking Test (6MWT)). A mixed model approach was applied to analyze the data.ResultsAt baseline, clinicians and patients (n=51) reported mostly fatigue (63% vs 79%), cough (49% vs 75%) and dyspnea (65% vs 73%) of any grade. Dyspnea (p=.041) increased over time. Meaningful clinical improvements were particularly seen in pain, fatigue, and cough. Clinician reported clinically meaningful improvements and deteriorations over time in fatigue, cough, and dyspnea. Almost at every timepoint, more people reported deterioration to the clinician than improvement in aforementioned toxicities. Overall HRQoL (p=.014), physical (p=.011) and emotional (p&lt;.001) functioning improved over time. At baseline, patients had a moderate daily functioning score and walked an average distance of 360 meters. No statistically significant differences were found in daily functioning and exercise capacity over time.ConclusionOur study showed an increase in patient-reported toxicity and dyspnea, without impacting functional status, following SBRT. Overall HRQoL, physical and emotional functioning improved over time. Understanding the impact of treatment on patient-reported outcomes is crucial to identify the needs/problems of patients to enhance their HRQoL.
The effect of teacher self-efficacy, teacher resilience, and emotion regulation on teacher burnout: a mediation model
Authors: Li Shanshan 
Published: August 2023

IntroductionThis research aimed to explore the relationships among teacher self-efficacy, teacher resilience, emotion regulation, and teacher burnout within the context of Chinese English as a foreign language (EFL) teachers.MethodsA sample of 638 Chinese EFL teachers participated in this study. They completed self-report assessments for teacher self-efficacy, teacher resilience, emotion regulation, and teacher burnout. Confirmatory factor analysis was conducted to establish the construct validity of the measurement tools. Subsequently, structural equation modeling was utilized to assess the proposed structural model.ResultsThe results of the study revealed significant insights. Teacher self-efficacy and resilience exhibited direct and negative associations with teacher burnout. Additionally, an interesting finding emerged where teacher emotion regulation indirectly affected teacher burnout, mediated by teacher resilience. The analysis supported the suitability of the partial mediation model as the best-fit representation of the relationships.DiscussionThe findings of this study provide valuable implications for EFL teaching programs. The negative connections between teacher self-efficacy, resilience, and burnout highlight the importance of nurturing these factors to mitigate burnout risk. The discovered mediation effect of teacher resilience emphasizes the role of emotion regulation in promoting teachers’ overall well-being. These outcomes collectively contribute to the understanding of teacher dynamics and suggest potential avenues for targeted interventions.
Effects of a video game intervention on symptoms, training motivation, and visuo-spatial memory in depression
Authors: Bergmann Moritz , Wollbrandt Ines , Gittel Lisa , Halbe Eva , Mackert Sarah , Philipsen Alexandra , Lux Silke 
Published: August 2023

BackgroundPeople with Major Depressive Disorder (MDD) often experience reduced affect, mood, and cognitive impairments such as memory problems. Although there are various treatments for MDD, many of them do not address the cognitive deficits associated with the disorder. Playing 3D video games has been found to improve cognitive functioning in healthy people, but it is not clear how they may affect depressed mood and motivation in people with MDD. The aim of this study was to investigate whether a six-week video game intervention leads to improvements in depressed mood, training motivation, and visuo-spatial (working) memory functions in patients with MDD.MethodsA total of 46 clinically depressed individuals were randomly assigned to one of three groups: an experimental “3D video gaming” group (n = 14) which played a video game, an active control group (n = 16) which trained with a computer program “CogPack,” and a treatment-as-usual group (n = 16) which received a standard clinical treatment including psychotherapy and/or pharmacotherapy. Participants performed a neuropsychological assessment, including self-report questionnaires asking for depressive symptoms, training motivation, and visuo-spatial (working) memory functions before and after the training intervention.ResultsRegarding depressive symptoms, a significant decrease in the proportion of participants who showed clinical levels of depressive symptoms as measured by the Beck Depression Inventory was only found in the 3D video gaming group. Additionally, mean motivational levels of performing the training were significantly higher in the 3D video gaming group when compared with the active control group. Moreover, whereas the 3D Video Gaming group only significantly improved on one visuo-spatial memory test, the active control group improved in all visuo-spatial memory functions. The 3D video gaming group did not perform significantly better than the CogPack group, and the TAU group.ConclusionBesides a standalone cognitive training, the current findings suggest that cognitive trainings using a video game have potential to increase subjective well-being, show higher levels of training motivation, and lead to improvements in visuo-spatial (working) memory functions in MDD. However, given the mixed and unblinded nature of this study, the results should be interpreted with caution. Further research with larger samples and follow-up measurements is needed.
The experience of healthcare workers to HIV pre-exposure prophylaxis (PrEP) implementation in low- and middle-income countries: a systematic review and qualitative meta-synthesis
Authors: Zhang Liao , Song Yuqing , Zheng Xutong , Liu Ying , Chen Hong 
Published: August 2023

BackgroundThe effectiveness of pre-exposure prophylaxis has been extensively documented. However, there are substantial gaps between the actual implementation of pre-exposure prophylaxis and the ideal goal, especially in low-and middle-income countries. Healthcare workers play critical roles in the pre-exposure prophylaxis implementation, and they have more multi-level experiences about the barriers of pre-exposure prophylaxis implementation and how to facilitate it. However, the evidence aiming to synthesize their experiences is limited.ObjectiveThis study aims to aggregate the healthcare workers’ experiences of providing pre-exposure prophylaxis in low-and middle-income countries, and find the barriers, facilitators, and recommendations of pre-exposure prophylaxis implementation.MethodsThe ENTREQ (Enhancing transparency in reporting the synthesis of qualitative research) statement was used to guide the design and reporting of this qualitative meta-synthesis. A comprehensive search was conducted from inception of databases to 16th March 2023 in four databases: PubMed, CINAHL Plus with Full Text, Embase, Web of Science. The quality appraisal was conducted using the Joanna Briggs Institute Critical Appraisal Checklist. JBI’s meta-aggregation approach was used to guide the data extraction and synthesis, and the JBI ConQual approach was used to evaluate the evidence level of the synthesized findings.ResultsFourteen articles with good methodological quality were included in this review. A total of 122 findings were extracted and 117 findings with credibility ratings of “unequivocal” or “equivocal” were included in this meta-synthesis. The eligible findings were aggregated into 13 new categories and subsequently developed into 3 synthesized findings: the barriers, facilitators, and recommendations of pre-exposure prophylaxis implementation in low-and middle-income countries. The overall ConQual score of all three synthesized findings was rated as “low.”ConclusionThis review aggregated the experience of health care workers implementing pre-exposure prophylaxis in low-and middle-income countries and we could focus on the following key points to promote the uptake of pre-exposure prophylaxis: improve knowledge about pre-exposure prophylaxis, create a supportive environment, address medication-related barriers, increase the human resources and financial investments, and diversify the providing models.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/. The protocol of this review has been registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42023411604).
Equatorial plasma bubbles features over the Brazilian sector according to the solar cycle and geomagnetic activity level
Authors: Carmo C. S. , Dai L. , Denardini C. M. , Figueiredo C. A. O. B. , Wrasse C. M. , Resende L. C. A. , Barros D. , Moro J. , Chen S. S. , Picanço G. A. S. , Silva R. P. , Wang C. , Li H. , Liu Z. 
Published: August 2023

Equatorial plasma bubbles (EPBs) can lead to signal degradation, affecting the measurement accuracy. Studying EPBs and their characteristics has gained increasing importance. The characteristics of EPBs were investigated using the rate of total electron content (TEC) index (ROTI) maps under different solar and magnetic activity conditions during two periods: July 2014–July 2015 (solar maximum activity with F10.7: 145.9 × 10−22 W⋅m−2⋅Hz−1) and July 2019–July 2020 (solar minimum activity with F10.7: 69.7 × 10−22 W⋅m−2⋅Hz−1). We also divided this analysis according to the magnetic activity levels based on Kp and Dst (disturbance storm time) indices, classified as follows: quiet+ (Kp ≤3 and Dst &gt;−30 nT), quiet− (Kp ≤3 and Dst &lt;−30 nT), disturbed weak (−50 nT &lt;Dst ≤−30 nT), moderate (−100 nT &lt;Dst ≤−50 nT), and intense (Dst ≤−100 nT). The ROTI is calculated using the slant TEC with the carrier phase, and its keograms are used to extract the zonal velocity and distance. Our statistical investigation shows the occurrence rate, duration, zonal drift velocity, and inter-bubble zonal distance of EPBs over the Brazilian sector. The latitudinal extension and zonal drift velocity of EPBs are higher during the solar maximum than those in the solar minimum. In addition, EPBs are found with unusually long durations, remaining until the morning (∼12 UT), and 10% of EPB observations occurred on the winter solstice.
Quantifying the Nonadiabaticity Strength Constant in Recently Discovered Highly Compressed Superconductors
Authors: Talantsev Evgeny F. 
Published: August 2023

Superconductivity in highly pressurized hydrides has become the primary direction for the exploration of the fundamental upper limit of the superconducting transition temperature, Tc, after Drozdov et al. (Nature 2015, 525, 73) discovered a superconducting state with Tc=203 K in highly compressed sulfur hydride. To date, several dozen high-temperature superconducting polyhydrides have been discovered and, in addition, it was recently reported that highly compressed titanium and scandium exhibit record-high Tc (up to 36 K). This exceeded the Tc=9.2 K value of niobium many times over, which was the record-high Tc ambient pressure metallic superconductor. Here, we analyzed the experimental data for the recently discovered high-pressure superconductors (which exhibit high transition temperatures within their classes): elemental titanium (Zhang et al., Nature Communications 2022; Liu et al., Phys. Rev. B 2022), TaH3 (He et al., Chinese Phys. Lett. 2023), LaBeH8 (Song et al., Phys. Rev. Lett. 2023), black phosphorous (Li et al., Proc. Natl. Acad. Sci. 2018; Jin et al., arXiv 2023), and violet (Wu et al., arXiv 2023) phosphorous to reveal the nonadiabaticity strength constant TθTF (where Tθ is the Debye temperature, and TF the Fermi temperature) in these superconductors. The analysis showed that the δ-phase of titanium and black phosphorous exhibits TθTF scores that are nearly identical to those associated with A15 superconductors, while the studied hydrides and violet phosphorous exhibit constants in the same ballpark as those of H3S and LaH10.
Classification of Russian Regions by the Level of Agricultural Development in 2019–2021
Authors: Mkhitaryan V. S. , Popova G. L. 
Published: August 2023

The urgency of improving mathematical and statistical tools for analyzing agricultural complex across the territories of our country depends on the gravity of the issue of interregional differentiation of the scale of development of agricultural production, which plays a crucial role in the implementation of the Food Security Doctrine of the Russian Federation.The introductory part of the article presents an overview of the literature on food security issues, an analysis of the current state of domestic agriculture, and directions for its development. The body of the article explains the research methodology, which allows to classify, first andforemost, agricultural regions (indicating their territorial location, socio-economic characteristics, and predictive characteristics). As an indicator of the intensity of agricultural development in the regions, the authors used the volume of agricultural production per capita, which became a criterion for selecting 25% of the regions with the maximum values of this indicator. That said, by an agro-region (or agricultural region) is meant a region that produces more agricultural production than needed and exports its surplus outside the region or country (food exports). In the multidimensional classification of agro-regions, three clusters are determined (according to the level of socio-economic development, the development efficiency of the economic activity «Agriculture, forestry, hunting, and fishing», and the volume of crop and livestock production). The paper analyses the dynamics and predictive characteristics of the development of the cluster-average volume of agricultural production per capita (including crop production and animal husbandry). An analysis of the dynamics of exports of food products and agricultural raw materials per capita by clusters revealed that the regions of the first cluster are the most actively developing, and the regions of the third cluster (with the most developed animal husbandry) are oriented towards domestic consumers.According to the authors, during the analyzed period in Russia, there was a positive trend in the development of agriculture, with the development of agro-regions outpacing all-Russian trends. The highest development rates are typical for agro-regions with a balanced development of crop and livestock production (regions of the first cluster).
Estudos de validade e confiabilidade da Escala de Avaliação dos Efeitos da Musicoterapia em Grupo na Dependência Química (MTDQ)
Authors: Pedrosa Frederico , Garcia Frederio , Gomes Cristiano Mauro Assis , Loureiro Cybelle Maria 
Published: August 2023

A Escala de Avaliação dos Efeitos da Musicoterapia em Grupo na Dependência Química (MTDQ) é um teste de autorrelato composto por 20 itens que avaliam os benefícios percebidos por pacientes adultos com dependência química sobre os efeitos da musicoterapia em grupo em seus processos de mudança. A MTDQ possui evidências de validade de conteúdo, mas carece de análises sobre outros aspectos da validade de um teste. Este estudo objetivou avaliar a validade estrutural e a confiabilidade da MTDQ. Através da análise fatorial confirmatória de itens, três modelos foram testados: unidimensional, dois fatores correlacionados e bifatorial. A amostra possui 202 adultos (44,7±12,7; 23,37%, mulheres) com dependência química que participaram de grupos de musicoterapia e responderam a MTDQ em um Centro de Referência de Saúde Mental Álcool e Drogas na cidade de Belo Horizonte/MG. Os resultados indicam adequação da estrutura bifatorial, composta por dois fatores específicos (processos cognitivos e processos comportamentais) e um fator geral. Este estudo traz evidências iniciais de que a MTDQ é um instrumento apropriado para medir três benefícios percebidos pelos pacientes com dependência química sobre a musicoterapia em seus processos de mudança.
Surface-activated direct bonding of diamond (100) and c-plane sapphire with high transparency for quantum applications
Authors: Miyatake Tetsuya , Kawaguchi Kenichi , Ohtomo Manabu , Iwai Toshiki , Ishiguro Tetsuro , Doi Yoshiyasu , Hermias Jeffrel , Nur Salahuddin , Ishihara Ryoichi , Sato Shintaro 
Published: August 2023

Abstract
Surface-activated direct bonding of diamond (100) and c-plane sapphire substrates is investigated using Ar atom beam irradiation and high-pressure contact at RT. The success probability of bonding strongly depends on the surface properties, i.e, atomic smoothness for the micron-order area and global flatness for the entire substrate. Structural analysis reveals that transformation from sapphire to Al-rich amorphous layer is key to obtaining stable bonding. The beam irradiation time has optimal conditions for sufficiently strong bonding, and strong bonding with a shear strength of more than 14 MPa is successfully realized. Moreover, by evaluating the photoluminescence of nitrogen-vacancy centers in the diamond substrate, the bonding interface is confirmed to have high transparency in the visible wavelength region. These results indicate that the method used in this work is a promising fabrication platform for quantum modules using diamonds.
Improving Utilization of the Chemotherapy Unit through Implementing the Medication Early Release Project
Authors: Alzahrani Mohsen , Alkaiyat Mohammad , Alshami Mona , Alotaibi Thamer , Meashi Sultan , Enizi Elham Al , Shehata Hussam , Khaleel Ammar , Esbaa Anas Abu , Harbi Reem Al , Alharbi Mohamad 
Published: August 2023

ABSTRACT

Introduction
The outpatient oncology infusion unit is very busy, serving 60 to 70 patients per day. Due to a limited number of nurses, treatment chairs, only one pharmacy hood for bio-hazardous drug preparation, and other factors, patients wait a long time before starting their treatment, which affects the patient experience negatively. We conducted a quality improvement project to reduce the waiting time before starting the treatment, improve the patients' experience, and allow the unit to work more effectively through better resource utilization and accommodating more patients.

Methods
A committee was formed with representatives from oncology nursing and the quality specialist, chemotherapy pharmacy supervisor, data manager, and a medical consultant (team leader). We studied baseline data of patient waiting times from January to March 2019 and the factors that contributed to delays before starting the treatment. The charge nurse identified patients who could safely have their medication released early in the morning at 7 am, enabling the pharmacy to dispense at 8 am without their actual presence being required in the infusion suite (i.e., medication early release program or MERP). Multiple plan-do-study-act (PDSA) cycles were implemented to achieve a wait time from check-in to medication administration of less than 60 minutes. Data collected included check-in time, chair time, vital signs time, administration time, and discharge time. Additionally, reasons for drug wastage were assessed for patients who did not receive the prepared medication. A patient satisfaction survey was conducted with the patients before and after being enrolled in the program.

Results
At baseline, average waiting time for patients receiving similar medications in the MERP was 2 hours and 27 minutes. After the first intervention, average waiting time was reduced to 1 hour and 24 minutes, and small improvements were observed after each PDSA cycl. A major breakthrough occurred after an intensive patient education program and enforcement of strict compliance with the criteria in selecting the patients appropriate for theMERP. Average waiting time wasreduced to ≤ 60 minutes, and in November 2022, it was 30 minutes on average. Drug wastage was identified as a balancing measure. We were successful in reducing drug wastage by implementing several changes and patient education measures and achieved zero wastage. The patient satisfaction survey showed better satisfaction with the new changes.

Conclusion
A positive impact was achieved in this quality improvement project, with a significant reduction in the average waiting time for patients to start receiving chemotherapy. The outcome of this project has been maintained for 4 years and is still ongoing.