bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porphyria: a case report
Authors: Baidya Sujata , Kandel Pratibha , Rajkarnikar Smrity , Kadel Anuradha , Niraula Apeksha , Dubey Raju Kumar , Lamichhane Machhindra , Raut Mithileshwer , Bhattarai Aseem , Tuladhar Eans Tara , Sharma Vijay Kumar 
Published: December 2022

Abstract
Background
Prompt diagnosis of metabolic disorders in a resource-limited country like Nepal is daunting. Acute intermittent porphyria is a rare but common hepatic porphyria mostly seen in females of the reproductive age group. As its incidence is quite uncommon, conjectures about porphyria diagnosis are often duped into a diagnostic conundrum.

Case presentation
Here we unravel a case of a 15-year-old Hindu Nepalese girl distraught by the myriad of symptoms in the setting of severe abdominal pain accompanied by constipation and limb pain as the chief complaints. She presented with acute severe hypertension with marked persistent hyponatremia (up to 109 mEq/L). Despite conservative management of hypertension and electrolytes, unresolved electrolyte imbalance led us to the speculation of disturbance in the renin–angiotensin–aldosterone system. Due to her exacerbating neurovisceral status, she also required intensive care during the disease course. After thorough investigations and exemption of presumed provisional diagnoses, based on sustained symptomatic presentation, the clinical suspicion was driven towards a diagnosis of porphyria-related disorders. Positive Watson-Schwartz test substantiated the diagnosis of acute intermittent porphyria. Her symptoms gradually abated after the consumption of high carbohydrate diets.

Conclusion
This case highlights the baffling amalgamation of symptoms that simulate common diseases of concern yet are buried in the realm of porphyric disorders. Porphyria can be diagnosed using simple screening tools and timely treatment can diminish serious consequences.
Dendrometric data from the silvicultural scenarios developed by Office National des Forêts (ONF) in France: a tool for applied research and carbon storage estimates
Authors: Fournier Salomé , Sardin Thierry , Dreyfus Philippe , Francois Didier , Mandret Xavier , Simeoni Marion , Renaud Jean-Pierre , Akroume Emila , Bouvet Alain , Berthelot Alain , Wernsdörfer Holger , Riviere Miguel , Sainte-Marie Julien , Breteau-Amores Sandrine , De Coligny François , Deleuze Christine 
Published: December 2022

Abstract
Key message
We provide a database of 52 silvicultural scenarios recommended in French public forests including relevant dendrometric variables and metrics for carbon accounting. The dataset is available at https://doi.org/10.57745/QARRFS. Associated metadata are available at https://metadata-afs.nancy.inra.fr/geonetwork/srv/fre/catalog.search#/metadata/f76ed27f-325d-493b-8731-0995dcaa7805. Special attention was paid to offer carbon metrics required for the French Label Bas Carbone offset projects.
The governance of energy transitions in Africa: a sketch of plural perspectives
Authors: Späth Philipp , Castán Broto Vanesa , Bawakyillenuo Simon , Pregernig Michael 
Published: December 2022

AbstractBuilding on the contributions to the article collection “The Governance of Sustainable Energy Transitions in the Global South “, this editorial offers a sketch for a research agenda on transitions research with a main focus on Africa. Still being ill-defined in its concrete contours, this research agenda engages with the central themes of heterogeneity, politics, and the material basis of energy transitions. In this editorial, we address both procedural and content-related questions. Regarding procedural questions, we inform about the context in which this collection emerged. On that, a workshop held in Accra in September 2019 was a key milestone. We contextualise the challenges that some workshop participants had with developing their contributions into publishable articles in the context of uneven academic support structures and knowledge hegemonies. Finally, we introduce the contributions to our article collection, emphasising how they connect and contribute to our draft research agenda. With regard to the content dimension, this article collection builds and proclaims the need for plural approaches to understanding energy transitions in Africa. A plurality of specific context conditions calls for pluralistic analytical perspectives. Not taking for granted hegemonic, western ways of understanding energy systems and explaining change, we rather depart from engagements with the diversity of changes that aggregate into transition pathways—a diversity that in the context of Africa is impossible to overlook. To implement such a pluralistic research agenda, scholars need more opportunities to network, exchange and publish.
An analysis of economic losses from cyberattacks: based on input–output model and production function
Authors: Kokaji Akiyoshi , Goto Atsuhiro 
Published: December 2022

AbstractThere has recently been a global increase in economic losses due to cyberattacks. However, research on the economic damage caused by cyberattacks has mainly focused on attacked companies, and spillover damage to other sectors has not been sufficiently investigated. This study analyzed the economic losses from cyberattacks in Japan using the production function and input–output model to improve the accuracy of damage prediction and various national measures. First, we provide an estimation method for the annual direct damage by industry using a production function. The mainstream input dataset is lost working hours owing to cyber incidents. Second, we devised a model to estimate the amount of spillover damage to the entire country using the input–output model. Third, although the cyber damage data were limited to only interview data by the JNSA and IPA, we showed the process of estimating direct and spillover damage in all sectors in Japan. As a result, we consider that our estimation method is feasible and effective at the national level. This study contributes to future research on cyber resilience by analyzing the damage caused by cyberattacks from a macroeconomic perspective using a production function and input–output model.
Circulating miR-320a-3p and miR-483-5p level associated with pharmacokinetic–pharmacodynamic profiles of rivaroxaban
Authors: Zhang Hanxu , Zhang Zhuo , Liu Zhiyan , Mu Guangyan , Xie Qiufen , Zhou Shuang , Wang Zhe , Cao Yu , Tan Yunlong , Wei Xiaohua , Yuan Dongdong , Xiang Qian , Cui Yimin 
Published: December 2022

Abstract
Background
Novel biomarkers for personalizing anticoagulation remain undetermined. We aimed to investigate the association of plasma miRNAs with pharmacokinetic–pharmacodynamic (PK-PD) profiles of rivaroxaban.

Methods
This is a multicenter, exploratory study of miRNAs in a Chinese population. Healthy volunteers and patients receiving rivaroxaban were enrolled in the study. The area under the plasma concentration–time curve from time 0-t h (AUC0-t) and anti-Xa activity at 3 h (AXA3h) were measured in healthy volunteers, and AXA3h was measured in patients. MiRNAs were detected by miRNA microarray in 26 healthy volunteers with 20 mg rivaroxaban, and quantitative reverse transcription polymerase chain reaction was used to exclude undetectable ones. MiR-320a-3p and miR-483-5p were then quantified in 65 healthy volunteers and 71 patients. MiRNA levels at 3 h were compared between high and low AXA3h or AUC0-t subjects and in matched patients with or without bleeding during follow-up. The miRNA targets were predicted by TargetScan, miRTarBase, and miRDB. Validated genes were included in GO enrichment and KEGG analyses. The protein–protein interaction network was established by STRING and visualized by Cytoscape.

Results
A total of 136 Chinese subjects completed the study. In healthy volunteers taking 15 mg rivaroxaban, the miR-320a level at 3 h was significantly positively correlated with AXA3h and AUC0-t (r = 0.359, p = 0.025; r = 0.370, p = 0.02, respectively). A positive correlation was also observed between miR-483 and AXA3h or AUC0-t (r = 0.372, p = 0.02; r = 0.523, p = 0.001, respectively). MiR-320a and miR-483 levels at 3 h in the higher AUC0-t group were significantly higher than those at 0 h. MiR-483 levels at 3 h may distinguish healthy volunteers with high or low AXA3h or AUC0-t. In the 10 mg fed subgroup, higher 3 h mir-483 levels were also observed compared with the control group. No significant differences were found in the comparisons among patients. Bioinformatic analysis showed that these miRNAs may play a regulatory role by targeting ABCG2, ITGB3, PTEN, MAPK1/3, etc.

Conclusions
MiR-320a and miR-483 levels were found to be associated with PK and PD profiles of rivaroxaban in healthy Chinese subjects. Further studies are required to verify these findings and explore the mechanisms.
Effects of ferric citrate hydrate in patients with chronic kidney disease and heart failure: subgroup analysis of a long-term, real-world, post-marketing surveillance study
Authors: Ito Kyoko , Murakami Kenjiro , Yamada Ryoichi , Susai Hiroyuki , Nishino Noriaki 
Published: December 2022

Abstract
Background
Iron deficiency is widely present in patients with heart failure (HF) and is associated with an increased risk of mortality and poor clinical outcomes regardless of anemia. HF is highly prevalent in patients with chronic kidney disease (CKD). However, existing oral iron preparations have failed to improve iron-related parameters in patients with HF, and intravenous iron preparations are recommended. Ferric citrate hydrate (FC) is an oral iron-based phosphate binder for CKD that is also approved for the treatment of patients with iron-deficiency anemia in Japan. In this subgroup analysis, we evaluated the effect of oral FC on iron-related parameters in CKD patients with and without HF.

Methods
We examined iron- and phosphate-related parameters and adverse drug reactions in subpopulations of CKD patients with and without HF enrolled in a previously reported 104-week, real-world, post-marketing surveillance study of FC in Japan.

Results
Among 2811 enrolled CKD patients, 348 patients had HF and 2352 did not have HF, including 166 and 1401 undergoing hemodialysis (HD), 36 and 173 undergoing peritoneal dialysis (PD), and 146 and 778 non-dialysis-dependent (ND) patients, respectively. The mean changes (95% confidence interval (CI)) in serum ferritin from baseline to week 36 were 90.98 (62.99–118.97) and 81.86 (72.68–91.03) ng/mL in HD, 158.64 (108.91–208.36) and 132.91 (98.59–167.23) ng/mL in PD, and 68.06 (40.40–95.73) and 99.75 (81.10–118.40) ng/mL in ND group, respectively. The mean changes (95% CI) in transferrin saturation (TSAT) (%) from baseline to week 12 in patients with and without HF were 12.79 (9.15–16.44) % and 9.57 (8.46–10.68) % in HD, 9.55 (1.31–17.78) % and 4.96 (1.44–8.48) % in PD, and 5.85 (2.02–9.69) % and 5.21 (3.34–7.09) in ND patients, respectively. Levels of these parameters were well maintained thereafter. Mean serum phosphate levels decreased after FC treatment initiation and were well maintained in all groups.

Conclusions
This study demonstrated that oral FC had a tendency to increase serum ferritin and TSAT, and controlled serum phosphate in CKD patients regardless of the presence of HF.
Trial registration This surveillance was conducted in accordance with the Good Post-marketing Study Practice of Ministry of Health, Labour, and Welfare in Japan.
Factors associated with prolonged hospitalization of patients with corona virus disease (COVID-19) in Uganda: a retrospective cohort study
Authors: Ingabire Prossie M. , Nantale Ritah , Sserwanja Quraish , Nakireka Susan , Musaba Milton W. , Muyinda Asad , Tumuhaise Criscent , Namulema Edith , Bongomin Felix , Napyo Agnes , Ainembabazi Rozen , Olum Ronald , Munabi Ian , Kiguli Sarah , Mukunya David 
Published: December 2022

Abstract
Introduction
Identification of factors predicting prolonged hospitalization of patients with coronavirus disease (COVID-19) guides the planning, care and flow of patients in the COVID-19 Treatment Units (CTUs). We determined the length of hospital stay and factors associated with prolonged hospitalization among patients with COVID-19 at six CTUs in Uganda.

Methods
We conducted a retrospective cohort study of patients admitted with COVID-19 between January and December 2021 in six CTUs in Uganda. We conducted generalized linear regression models of the binomial family with a log link and robust variance estimation to estimate risk ratios of selected exposure variables and prolonged hospitalization (defined as a hospital stay for 14 days or more). We also conducted negative binomial regression models with robust variance to estimate the rate ratios between selected exposures and hospitalization duration.

Results
Data from 968 participants were analyzed. The median length of hospitalization was 5 (range: 1–89) days. A total of 136/968 (14.1%: 95% confidence interval (CI): 11.9–16.4%) patients had prolonged hospitalization. Hospitalization in a public facility (adjusted risk ratio (ARR) = 2.49, 95% CI: 1.65–3.76), critical COVID-19 severity scores (ARR = 3.24: 95% CI: 1.01–10.42), and malaria co-infection (adjusted incident rate ratio (AIRR) = 0.67: 95% CI: 0.55–0.83) were associated with prolonged hospitalization.

Conclusion
One out of seven COVID-19 patients had prolonged hospitalization. Healthcare providers in public health facilities should watch out for unnecessary hospitalization. We encourage screening for possible co-morbidities such as malaria among patients admitted for COVID-19.
First report of a patient meeting criteria for both multisystem inflammatory syndrome in children and adult onset Still’s disease
Authors: Alexandri Maya , Patel Julisa , Paul Eli , Coule Lynne W. 
Published: December 2022

Abstract
Background
COVID-19 is associated with a postinfectious hyperinflammatory disorder, multisystem inflammatory syndrome in children (MIS-C), that shares characteristics with still’s disease, known as systemic juvenile idiopathic arthritis (SJIA) in children younger than 16, and adult onset Still’s disease (AOSD) in children 16 and older. Both MIS-C and SJIA/AOSD can be complicated by macrophage activation syndrome (MAS), a potentially fatal condition of cytokine storm.

Case presentation
We present a 16 year-old male who developed quotidian fever, headache, conjunctival injection, sore throat, nausea and vomiting, diarrhea, rash, and symmetrical polyarticular arthralgia/arthritis 4 weeks after exposure to SARS-CoV-2 and 2 weeks after his first vaccination against COVID-19. Our patient’s laboratory results were significant for elevated inflammatory markers and acute phase reactants. He met criteria for diagnosis with both MIS-C and AOSD. After receiving first-line treatment for both diseases, IVIG and methylprednisolone, our patient improved.

Conclusion
MAS is a life-threatening rheumatological emergency, and physicians must be able to identify diseases, like MIS-C and AOSD, that may be complicated by MAS. Our patient’s distinguishing feature on presentation was symmetrical polyarticular arthralgia/arthritis, which has not been associated with MIS-C. Simultaneously, AOSD—which is associated with polyarticular arthralgia/arthritis—is only now being recognized as a possible post-infectious entity in the aftermath of COVID-19 infection. In patients like our own, who meet criteria for both MIS-C and AOSD, administering first line treatment for both diseases may be best practice.
Systemic paracoccidioidomycosis in a patient with enzymatic myeloperoxidase deficiency and acute lymphoblastic leukemia: case report
Authors: Hoyos Sebastián , Agudelo Cristián Camilo , Lozano Diana Mercedes , Buitrago Luis Eduardo 
Published: December 2022

Abstract
Background
Paracoccidioidomycosis is a systemic fungal infection that is potentially fatal, and the most prevalent of its kind in Latin America. The predisposition to infection appears to be related to abnormalities in cellular immunity, given its low prevalence in endemic regions. The role of myeloperoxidase deficiency has not been elucidated.

Case presentation
We present a case of 48-year-old female patient with acute lymphoblastic leukemia, stem cell transplant candidate, who developed a fever with lymphadenopathy and lung nodules, consistent with paracoccidioidomycosis infection, in whom a myeloperoxidase deficiency was later discovered. The treatment of the hematologic malignancy had a good impact solving the enzymatic deficiency and antifungal therapy achieve controlling the infection.

Conclusions
This case lays out the possible association between acute leukemia, an alteration in neutrophil function (needed to fight fungal infections) and an infection due to Paracoccidioides brasiliensis.
Regeneration of beaded activated carbon saturated with volatile organic compounds by a novel electrothermal swing adsorption system
Authors: Yu Hao-Chih , You Shu-Wen , Wang Can , Deng Ji-Guang , Hsi Hsing-Cheng 
Published: December 2022

AbstractA commercially available beaded activated carbon (KBAC) was selected for combination with a novel electrothermal swing system in examining the Joule heating effects on the physical and chemical properties of activated carbon and its adsorption regenerability at various regeneration temperatures (120, 140, and 160 °C) after saturation by toluene (TOL) and methylethylketone (MEK). The specific surface area (1278 m2 g− 1) and micropore volume (0.48 cm3 g− 1) for KBAC after one adsorption/desorption cycle were slightly reduced, while KBAC micropore surface area (1158 m2 g− 1) and micropore volume decreased significantly after six adsorption/desorption cycles. It can be inferred that the pores of KBAC, especially micropores, are blocked by heel buildup caused mainly by formation of cracked TOL and MEK coke generated by cyclic Joule heating. The desorption efficiencies of TOL-KBAC and MEK-KBAC (KBAC saturated with TOL and MEK, respectively) evaluated per the gravimetric method ranged from 55 to 80 and 85–90%, respectively, and both showed great correlation between regeneration temperature and desorption efficiency. Notably, the desorption efficiencies calculated from the integral method based on breakthrough curves were 8 and 16% lower than those directly obtained by the gravitational method for TOL-KBAC and MEK-KBAC, respectively. The larger difference in desorption efficiency evaluated by the two methods for MEK-KBAC is likely caused by the decomposition of MEK into CO or CO2, which was less prominent in TOL-KBAC. In the cyclic adsorption/desorption tests, the adsorption capacities of both TOL-KBAC and MEK-KBAC decreased after the 6-cycle electrothermal swing regeneration, such that TOL-KBAC adsorption capacity significantly reduced to around 50%, while that of MEK-KBAC retained around 70% of their respective original adsorption capacities. As aforementioned, heel buildup blocks the pores and leads to decreasing adsorption, especially for TOL.
Similar, yet different! Comparing Ugandan secondary cities’ food system and nutritional transformations to findings from African primary cities
Authors: Mackay Heather , Tusabe Richard , Mugagga Frank 
Published: December 2022

AbstractThis research focuses on the food, farming and health experiences of two secondary cities of Uganda (Mbale and Mbarara), comparing findings with studies of primary African cities. We draw from survey data, focus groups with healthcare professionals, and in-depth interviews with varied residents. A feminist geographic perspective explored intersections of food, farming and health with varied aspects of identity, and with place (city itself, but also with rural areas). By comparing our secondary city findings to findings from primary African cities this paper sheds light on whether and how food systems in secondary African cities are transforming, and how urban life at this scale is being experienced. Our analysis suggests a good deal of similarity of food insecurity, dietary diversity, and of non-communicable disease experiences and understandings. The main difference was around the food access strategies, the access to land, and the engagement with agriculture and interaction with the rural. How this might change as these secondary cities grow further is not clear but there should not be an assumption that primary city experiences will inevitably be followed. Our findings offer important insights for future research and for those planning for Ugandan and potentially other African secondary city futures. In comparison to primary SSA cities our findings suggest less advance along theorised nutritional transitions (greater hybridity), a higher relevance of the rural for viable urban lives, yet comparable experience of non-communicable disease. This is intriguing, has implications for theory, and warrants further research.
The role of repetitive transcranial magnetic stimulation in reduction of opioid craving: a single-blinded randomized sham-controlled clinical trial
Authors: Elrassas Hanan H. , Morsy Mahmoud H. , Abdelrazek Yasser M. , El Rasheed Amany H. , Saad Noha A. , Azzam Lobna A. 
Published: December 2022

Abstract
Background
Opioid use disorder (OUD) poses a great concern due to problems associated with their abuse as well as fatal and non-fatal overdose consequences. Craving has a complex relationship with opioid use and relapse. Developing new, effective treatments for substance use disorders (SUDs), including opioid use disorders is crucial. This study aimed to assess the effect of 18 sessions of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) on opioid craving in 26 OUD male patients compared to sham rTMS in 26 OUD patients, during early abstinence, with craving assessment using brief substance craving scale (BSCS) for tramadol and morphine and heroin craving questionnaire (HCQ) for heroin craving.

Results
There was a statistically significant reduction in craving scores in the group of OUD patients receiving real rTMS compared to those receiving sham rTMS for both BSCS (p value = 0.044) and HCQ (p value=0.002). A statistically significant positive correlation was revealed between the number of hospital admissions and the mean scores of post-rTMS HCQ scores (r=0.05, p value= 0.040).

Conclusions
A high frequency of 10-Hz rTMS over the left DLPFC for 18 treatment sessions reduced craving OUD patients during early abstinence. These preliminary results suggest that 10-Hz rTMS of the left DLPFC may be used in the treatment of OUD, so our study recommends that the use of rTMS in the reduction of opioid craving in early abstinence.

Trial registration
Unique identification number PACTR202206487514449 in the Pan African Clinical Trial Registry retrospectively (www.pactr.org) registered on 10 June 2022.