bluuebunny/crossref_metadata_2025_split huggingface dataset:
AF driver detection in pulmonary vein area by electropcardiographic imaging: Relation with a favorable outcome of pulmonary vein isolation
Authors: Fambuena-Santos Carlos , Hernández-Romero Ismael , Molero Rubén , Atienza Felipe , Climent Andreu M. , Guillem M S. 
Published: January 2023

Pulmonary vein isolation (PVI) is the most successful treatment for atrial fibrillation (AF) nowadays. However, not all AF patients benefit from PVI. In this study, we evaluate the use of ECGI to identify reentries and relate rotor density in the pulmonary vein (PV) area as an indicator of PVI outcome. Rotor maps were computed in a set of 29 AF patients using a new rotor detection algorithm. The relationship between the distribution of reentrant activity and the clinical outcome after PVI was studied. The number of rotors and proportion of PSs in different atrial regions were computed and compared retrospectively in two groups of patients: patients that remained in sinus rhythm 6 months after PVI and patients with arrhythmia recurrence. The total number of rotors obtained was higher in patients returning to arrhythmia after the ablation (4.31 ± 2.77 vs. 3.58 ± 2.67%, p = 0.018). However, a significantly higher concentration of PSs in the pulmonary veins was found in patients that remained in sinus rhythm (10.20 ± 12.40% vs. 5.19 ± 9.13%, p = 0.011) 6 months after PVI. The results obtained show a direct relationship between the expected AF mechanism and the electrophysiological parameters provided by ECGI, suggesting that this technology offers relevant information to predict the clinical outcome after PVI in AF patients.
Short-term isolation effects on the brain, cognitive performance, and sleep—The role of exercise
Authors: Klein Timo , Braunsmann Leonard , Koschate Jessica , Hoffmann Uwe , Foitschik Tina , Krieger Stephanie , Crucian Brian , Schneider Stefan , Abeln Vera 
Published: January 2023

Isolation is stressful and negatively affects sleep and mood and might also affect the structure and function of the brain. Physical exercise improves brain function. We investigated the influence of physical exercise during isolation on sleep, affect, and neurobehavioral function. N = 16 were isolated for 30 days with daily exercise routines (ISO100) and n = 16 isolated for 45 days with every second day exercise (ISO50). N = 27 were non-isolated controls who either exercised on a daily basis (CTRLEx) or refused exercise (CTRLNonEx) for 30 days. At the beginning and the end of each intervention, intravenous morning cortisol, melatonin, brain-derived neurotrophic factor and IGF-1, positive and negative affect scales, electroencephalography, cognitive function, and sleep patterns (actigraphy) were assessed. High levels of cortisol were observed for the isolated groups (p &lt; .05) without negative effects on the brain, cognitive function, sleep, and mood after 4 to 6 weeks of isolation, where physical exercise was performed regularly. An increase in cortisol and impairments of sleep quality, mood, cognitive function, and neurotrophic factors (p &lt; .05) were observed after 4 weeks of absence of physical exercise in the CTRLNonEx group. These findings raise the assumption that regular physical exercise routines are a key component during isolation to maintain brain health and function.
Testing the theoretical principles of citizen science in monitoring stream water levels through photo-trap frames
Authors: Spasiano Andrea , Grimaldi Salvatore , Nardi Fernando , Noto Simone , Braccini Alessio M. 
Published: January 2023

IntroductionMonitoring water levels of ephemeral streams is a difficult yet important task in hydrology, especially when studying minor river flows in remote areas. The installation of flow gauging stations on upstream tributaries is impacted by the lack of economic resources, by accessibility problems and unstable morphological conditions of riverbeds avoiding the implementation of distributed observation networks at large scales. This major challenge in hydrology may be addressed by eventually adopting image-analysis approaches that constitute an effective parsimonious river flow monitoring method, but the demonstration of such techniques is still an open research topic.MethodologyThis study focuses on the testing of a novel technique that employs a white pole “staff gauge” to be photographed using a phototrap (i.e., named stage-cam which is a high-speed camera trigger system). This technology shows to be particularly efficient for observing flood events that represent the most difficult scenario for streamflow monitoring. Furthermore, the testing of this innovative hydrological data-gathering method is performed by adopting citizen science and participatory image analysis to assess the value and effectiveness of non-expert volunteers to operationalize this novel method. Citizen engagement may be essential for supporting distributed flow monitoring supporting large scale image analysis algorithm calibration associated to a continuous series of phototrap images. The Montecalvello watershed, located near Rome, is selected for this pilot case study.ResultsResults of the conducted tests, involving the University of Tuscia student community, are presented toward the demonstration of the effectiveness of citizen science to collect valid quantitative hydrological observations, which may correlate consistently with expert estimates. To better interpret results, the authors consider mean absolute error (MAE) and mean absolute relative error (MARE) as synthetic indices to determine the uncertainties associated to voluntary observations. Low margins of error return positive feedback on the adopted methodology.DiscussionThis research promotes the use of participatory approaches for addressing an actual hydrological monitoring challenge. In addition, it fosters increased citizen knowledge and awareness of the importance and value of hydrological monitoring of small ungauged river basins.
Which nutritional prognosis is better? comparison of the three most commonly performed bariatric surgeries: A systematic review and network meta-analysis
Authors: Cui Yuanyao , Zhang Di , Wang Li , Liu Xuefei , Wang Chunyan , Tian Shuyun , Li Meiqu 
Published: January 2023

BackgroundObesity is one of the most important public health conditions in the world, and surgical intervention is the only medical treatment recognized by the medical community as a complete and permanent cure for morbid obesity and its complications. The choice of surgical modality is also based more on the experience of the physician or the requirements of people with obesity, rather than on scientific data. In this issue, a thorough comparison of the nutritional deficiencies caused by the three most commonly used surgical modalities is needed.ObjectivesWe aimed to use the network meta-analysis to compare the nutritional deficiencies caused by the three most common BS procedures in many subjects who underwent BS to help physicians determine the best BS surgical approach to apply to their clinical people with obesity.SettingA systematic review and network meta-analysis of world literature.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, systematically reviewed the literature, and conducted a network meta-analysis using R Studio.ResultsFor the four vitamins calcium, vitamin B12, iron and vitamin D, the micronutrient deficiency caused by RYGB is the most serious.ConclusionsRYGB causes slightly higher nutritional deficiencies in Bariatric surgery, but RYGB remains the most commonly used modality for Bariatric surgery.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022351956, identifier: CRD42022351956.
Economic Impact of European Liver and Intestine Transplantation Association (ELITA) Recommendations for Hepatitis B Prophylaxis After Liver Transplantation
Authors: Cortesi Paolo Angelo , Viganò Raffaella , Conti Sara , Lenci Ilaria , Volpes Riccardo , Martini Silvia , Angelico Mario , Fung James , Buti Maria , Coilly Audrey , Durand Francois , Fondevila Constantino , Lebray Pascal , Nevens Frederik , Polak Wojciech G. , Rizzetto Mario , Zoulim Fabien , Perricone Giovanni , Berenguer Marina , Mantovani Lorenzo Giovanni , Duvoux Christophe , Belli Luca Saverio 
Published: January 2023

The European Liver and Intestine Transplant Association, ELITA, promoted a Consensus Conference involving 20 experts across the world which generated updated guidelines on HBV prophylaxis in liver transplant candidates and recipients. This study explores the economic impact associated with the implementation of the new ELITA guidelines. To this aim, a condition-specific cohort simulation model has been developed to compare new and historical prophylaxis, including only pharmaceutical cost and using the European perspective. The target population simulated in the model included both prevalent and incident cases, and consisted of 6,133 patients after the first year, that increased to 7,442 and 8,743 patents after 5 and 10 years from its implementation. The ELITA protocols allowed a cost saving of around € 235.65 million after 5 years and € 540.73 million after 10 years; which was mainly due to early HIBG withdrawal either after the first 4 weeks or after the first year post Liver Transplantation (LT) depending on the virological risk at transplantation. Results were confirmed by sensitivity analyses. The money saved by the implementation of the ELITA guidelines would allow healthcare decision makers and budget holders to understand where costs could be reduced and resources re-allocated to different needs.
Antiproliferative Activity of Antibiotics through DNA Binding Mechanism: Evaluation and Molecular Docking Studies
Authors: Magklaras Alexandros-Dimitrios C. , Banti Christina N. , Hadjikakou Sotiris K. 
Published: January 2023

The antiproliferative activity of three antibiotics clinically use, was studied through DNA inhibition mechanisms, ex vivo, in silico and in vitro. The ex vivo interaction of DNA with ciprofloxacin hydrochloride (CIP·HCl), penicillin G sodium salt (PEN·Na), and tetracycline hydrochloride (TC·HCl) was determined by UV-Vis spectra and viscosity measurements. Furthermore, their binding constants (Kb) toward CT-DNA were calculated (Kb = (2.8 ± 0.6) × 104 (CIP·HCl), (0.4 ± 0.1) × 104 (PEN·Na) and (6.9 ± 0.3) × 104 (TC·HCl) Μ−1). Docking studies on the binding interactions of antibiotics with DNA were performed to rationalize the ex vivo results. The in vitro antiproliferative activity of the antibiotics was evaluated against human breast adenocarcinoma (MCF-7) cells (IC50 values: 417.4 ± 28.2 (CIP·HCl), >2000 (PEN·Na) and 443.1 ± 17.2 (TC·HCl) μΜ). Cell cycle arrest studies confirmed the apoptotic type of MCF-7 cells. The toxicity of the studied agents was in vitro tested against human fetal lung fibroblast cells (MRC-5). The results are compared with the corresponding one for doxorubicin (DOX). Despite their low binding affinity to DNA (Kb) or their different mode of interaction, TC·HCl (anthracycline) or CIP·HCl (quinolones), exhibit notable antiproliferative activity and low toxicity.
Modeling the Magnetic Field of the Inner Corona in a Radially Expanding Solar Wind
Authors: Tlatov Andrey G. , Berezin Ivan 
Published: January 2023

The magnetic field in the interplanetary medium is formed by the action of magnetic field sources on the photosphere of the Sun and currents in the expanding atmosphere of the Sun and the solar wind. In turn, the high-speed plasma flow changes the configuration of the magnetic field lines. The problem of determining the parameters of the magnetic field near the Sun is thus a three-dimensional problem of the interaction of the magnetic field and the plasma of the solar wind. We present analytical expressions for calculating the total magnetic field vector B→(r, θ, ϕ) (in spherical coordinates) for a radially expanding solar wind flow of finite conductivity. The parameters of the solar wind are given in the form of a dimensionless magnetic Reynolds number given as an arbitrary function of the radius, r: Rm = rσμv=ξ(r), where σ, μ, and v denote, respectively, the conductivity, magnetic permeability, and velocity of the solar wind. The solution for the magnetic field components is obtained in the form of a decomposition in spherical functions and a radial part depending on the distance from the Sun. Examples of calculations of the configuration of magnetic fields and structures of the solar corona for the solar eclipse of 21 August 2017 are given.
CONSTRUCTION WITH A U-SHAPED PROFILE GRILLE
Authors: Марутян А. С. 
Published: January 2023

Приведен сравнительный расчет оптимальных параметров стержневых элементов из V- и U-образных профилей. Оба они оптимизированы по критерию равноустойчивости. Первый получен в результате раскрытия полок равнобокого уголка на угол, меньший прямого, и применен в качестве прототипа для второго. U-образный профиль состоит из двух вертикальных стенок, соединенных круглым полукольцом, и отличается отношением габаритных размеров ширины и высоты 1/1,39 по средней линии его расчетного сечения. Тестирование приближенной методики расчета подтвердило ее необходимую и достаточную корректность, остающуюся в пределах погрешностей конечно-элементного моделирования. Результаты расчета показали, что при одинаковом расходе конструкционного материала U-образный профиль более предпочтителен, поскольку его размеры компактнее, а ресурсы несущей способности больше.
A comparative calculation of the optimal parameters of rod elements from V- and U-shaped profiles is given. Both of them are optimized according to the criterion of equidistance. The first one was obtained as a result of opening the shelves of an equilateral corner by an angle smaller than a straight one, and was used as a prototype for the second one. The U-shaped profile consists of two vertical walls connected by a circular semicircle, and differs in the ratio of overall dimensions of width and height 1/1.39 along the middle line of its design section. Testing of the approximate calculation method confirmed its necessary and sufficient correctness, remaining within the limits of errors of finite element modeling. The results of the calculations showed that with the same consumption of structural material, the U-shaped profile is more preferable, since its dimensions are more compact, and the load-bearing capacity resources are greater.
Aktivitas Antibakteri Ekstrak Etanol Daun Wortel (Daucus Carota L.) Terhadap Klebsiella Pneumoniae Dan Pseudomonas Aeruginosa
Authors: Deka Muhammad Arfa D , Monica Salasa Alfrida , Rachmawaty Dwi 
Published: January 2023

Limbah daun wortel (Daucus carota L.) mengandung metabolit sekunder yang memiliki aktivitas antibakteri seperti tannin, steroid, dan saponin, namun selama ini belum dimanfaatkan secara optimal. Tujuan penelitian ini yaitu mengetahui aktivitas antibakteri ekstrak etanol daun wortel terhadap Klebsiella pneumoniae dan Pseudomonas aeruginosa. Metode Ekstraksi maserasi digunakan dengan menggunakan Etanol 96% kemudian aktivitas antibakteri diuji dengan metode difusi agar. Konsentrasi ekstrak yaitu 2%, 4%, dan 8% b/v. Hasil penelitian menunjukkan bahwa rerata diameter zona hambat untuk Klebsiella pneumoniae yaitu pada konsentrasi 2% b/v sebesar 10,33 mm, konsentrasi 4% b/v sebesar 13,67 mm, konsentrasi 8% b/v sebesar 16,33 mm sedangkan ciprofloxacin sebagai kontrol positif sebesar 36 mm dan DMSO sebagai kontrol negatif tidak menunjukkan adanya zona hambat. Sedangkan diameter zona hambat terhadap Pseudomonas aeruginosa diperoleh rata-rata diameter zona hambat untuk konsentrasi 2% b/v, 4% b/v dan 8% b/v adalah sebesar 11,33 mm, 16,33 mm, 20,33 mm, sedangkan pada ciprofloxacin 38,33 mm, dan kontrol negatif tidak memiliki zona hambat. Hasil uji statistik menunjukkan ekstrak etanol daun wortel memiliki aktivitas antibakteri terhadap Klebsiella pneumoniae dan Pseudomonas aeruginosa dengan konsentrasi yang paling optimal adalah 8% b/v (P < 0,05).
Analisis Pendapatan Usahatani Buah Naga Di Desa Konarom Kecamatan Dumoga Tenggara Kabupaten Bolaang Mongondow
Authors: Djogolang Geri Gein Fadila Aprilia , Lolowang Tommy F. , Ruauw Eyverson 
Published: January 2023

This research aims to analyze the income of dragon fruit farming in Konarom Village, Southeast Dumoga District, Bolaang Mongondow Regency, and analyze the feasibility of dragon fruit farming in Konarom Village, Southeast Dumoga District, Bolaang Mongondow Regency. The method used in this research is a survey method. The data used in this study are primary data and secondary data. Primary data was used through direct interviews using a questionnaire containing written questions to dragon fruit farmers, while secondary data was obtained from the village office and related agencies in this study with various literature on the internet. The data analysis method used in this research is descriptive analysis. The results showed that the land area of 3 dragon fruit farmers was 0.75-1 Ha. With total revenue is Rp. 516,750,000/Year. With a total cost of Rp. 144,189,000/Year, with the average amount of dragon fruit farming production is 11,483 Kg/Year. The income of dragon fruit farming in Konarom Village, Southeast Dumoga District, Bolaang Mongondow Regency is Rp. 372,561,000/Year. Judging from the value of the R / C ratio of 3.5. So it can be seen that dragon fruit farming is profitable and feasible to cultivate.
Evaluasi Pengembangan Objek Wisata Hutan Pinus Buntudatu Kecamatan Mengkendek Kabupaten Tana Toraja
Authors: Beka’ Astuti Anna , Saroinsong Fabiola B. , Kalangi Josephus I. 
Published: January 2023

The tourist attraction of the Buntudatu pine forest, Mengkendek District, Tana Toraja Regency is an open nature tourism object of limited production forest managed by the Buntudatu Village Owned Enterprise (BUMDes) as a place for activities such as recreation, camping, relaxing. The purpose of this study was to describe and evaluate the potential development of the Buntudatu pine forest tourism object based on the observations and perceptions of visitors. The variables observed were the attractiveness, accessibility and infrastructure of the Buntudatu pine forest tourism object. Data collection methods were carried out through observation and distributing questionnaires to visitors who were found in the tourist area of Buntudatu pine forest as many as 36 respondents. The data obtained were analyzed based on the assessment of ODTWA (Objects of Natural Tourist Attraction) and the Likert scale. The results showed that based on the ODTWA assessment, the potential development of tourism objects in the Buntudatu pine forest area obtained an attractiveness value of 750 in the medium category, accessibility with a total score of 450 in the high category and infrastructure facilities a total score of 300 in the high category. Based on the visitor's perception of attractiveness, it is categorized as good with a score of 72.66%, accessibility has a good category value with a score of 68.69% from respondents, facilities have a good value with a value of 66.66% and tourist activities get a very good score of 100%.
EDUKASI PEMBELAJARAN DARING TERHADAP ANAK SEKOLAH DASAR
Authors: Priskila Naomi 
Published: January 2023

Kuliah Kerja Nyata (KKN) adalah suatu kegiatan intrakurikuler yang memadukan pelaksanaan tri dharma perguruan tinggi (pendidikan, penelitian, dan pengabdian kepada masyarakat). Pandemi covid-19 mempengaruhi banyak hal, salah satunya adalah pendidikan. Di Indonesia, sistem pendidikan yang berlangsung adalah secara tatap muka, tetapi dikarenakan pandemi ini maka sistem tatap muka kemudian diubah menjadi sistem pembelajaran secara daring atau melalui jarak jauh dengan menggunakan media pembelajaran daring. Pelaksanaan KKN Mandiri, untuk program kerja individu penulis memilih untuk mengedukasi pembelajaran daring kepada anak sekolah dasar di lingkungan rumah Jl. Akmaliah Raya RT.06/RW.10, Pengasinan, Kec. Sawangan, Kota Depok. Pelaksanaan KKN Mandiri berjalan dengan lancar sesuai dengan harapan penulis dan hasil dari sosialisasi yang penulis lakukan, berdampak pada pengetahuan anak sekolah dasar akan pembelajaran daring melalui Grup Whatsapp dan disiplin protokol kesehatan.
ANALISIS PENERAPAN HYBRID WORKING DALAM MENINGKATKAN PRODUKTIVITAS KERJA PEGAWAI PADA DINAS KOPERASI & UMKM PROVINSI SULAWESI TENGGARA
Authors: Darpin  , Taufik  , Muhammad Fikran  
Published: January 2023

This study aims to find out how the application of hybrid working in increasing employee work productivity. The method used in this study is a type of qualitative research with case studies at the Dinas Koperasi, Usaha Mikro Kecil dan Menengah (UMKM) of Southeast Sulawesi Province. The data collection techniques used in this study were observation, interview and documentation. Data analysis techniques through data reduction, data presentation, and drawing conclusions. The results showed that the application of hybrid working runs optimally and has a good impact on employee work productivity. This can be seen from several factors that support the implementation of the hybrid work concept such as the availability of infrastructure and technology is enough to do digital-based work. The work productivity of employees during the implementation of hybrid working is also good which can be seen from the aspects of knowledge, skills, abilities and attitudes that employees have are also very good. Employees are able to adapt when work that is usually done conventionally must be done online or virtually. By using digital-based infrastructure, employees can work effectively and efficiently, so the results of this study show that employees can adapt and be able to work well during the implementation of hybrid working.
Three-dimensional finite-difference time-domain simulation of moving sound source and receiver with directivity
Authors: Tsuchiya Takao , Teshima Yu , Hiryu Shizuko 
Published: January 2023

AbstractIn this paper, the implementation of a moving sound source and receiver with directivity in the three-dimensional finite-difference time-domain method is described. Fundamental solutions of moving monopole, dipole, and cardioid sources are theoretically derived. Some numerical experiments were performed on the three-dimensional sound field for a moving source and receiver. The numerical experiments showed that the effect of moving velocity on amplitude differs for the monopole and dipole or cardioid sources. Furthermore, it was found that the directivity characteristics of dipole and cardioid sources vary depending on the beam and moving directions. The present method can be accurately applied to the moving sound source and receiver with directivity.
Nanowire single-crystal grain and single grain boundary silicon field effect transistors for direct electrical characterization of grain boundaries
Authors: Nguyen Thi Thuy , Hirata Tatsuaki , Kuroki Shin-Ichiro 
Published: January 2023

Abstract
Single crystal grain (s-G) and single grain boundary (s-GB) Si field effect transistors (FETs) were investigated for direct measurement of the electrical activity of GBs. Ultrahigh-performance nanowire s-G FET with 1360 cm2V−1s−1 electron field-effect mobility (μ
ef) was achieved on a transparent substrate. The significant difference of μ
ef values between nanowire and microwire FETs proved that uniaxial tensile strain typically contributed to μ
ef enhancement in nanowire FETs. Longitudinal GBs typically increased the leakage current and S factor due to a large donor concentration. The donor concentration generated by Σ3 and other CSL-type s-GBs was estimated.