bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding the Chemical Space of Non‐Proteinogenic N4‐Substituted Asparagine: Racemic, Enantioenriched, and Deuterated Derivatives
Authors: Pissinati Emanuele F. , Delgado José A. C. , Moro Pedro A. M. , Correia José T. M. , Berlinck Roberto G. S. , Paixão Márcio W. 
Published: April 2023

AbstractA site‐selective carbamoylation strategy to access non‐proteinogenic N4‐modified asparagines has been described. The protocol is characterized by mild reaction conditions, high functional group compatibility, and a wide diversity of functionalized carbamoyl radicals making possible the access to peptides, pharmaceuticals, and natural N4‐asparagine conjugates, as well as enantioenriched unnatural N4‐asparagines. Besides that, deuterated analogues were achieved with the insertion of D2O and enantioenriched derivatives could be obtained in 15 min in continuous‐flow conditions.
Breaking down re‐enrollment barriers for adult learners improves the college experience for all
Authors: Sutton Halley 
Published: April 2023

CHICAGO — Re‐engaging your stopped‐out adult learners can be an effective tool in your arsenal for dramatically boosting completion rates, not to mention changing the lives of the students in your community. “We know who [these students] are: when they stopped out, why they stopped out. It's rarely that they failed out, but more likely they ‘lifed’ out in some way,” said Tony Sheppard, Professor and Program Coordinator of Hospital Management & Tourism at Sacramento State University.
A study on economic, efficiency and environment (EEE) impact of different fuels used in boilers to assist decision making in fuel conversion and enhance sustainability
Authors: Jena Madhab Chandra , Mishra Sarat Kumar , Moharana Himanshu Sekhar 
Published: April 2023

AbstractBoilers using different fuels like HSD, LDO, coal, PNG and propane were taken into consideration in this study. Different parameters associated with boilers like economic factor, efficiency factor and the environmental impact factor were being calculated by taking measurements and collecting data from different plants in Odisha with variety of fuels. It is found that the most economical fuel is coal with a price index of 4.69 Rs/megacalorie and the most expensive fuel is LDO with a price index of 9.83 Rs/megacalorie. The most efficient boilers are propane‐fired boilers with an efficiency of 95.1% and least efficient boilers are coal‐fired boilers with an efficiency of 88.8%. PNG‐fired boilers had the lowest environmental impact around 1.0 and coal‐fired boilers had the highest around 6.0. A new concept of EEE impact index has been introduced which denotes the combined impact of Economic factor, Efficiency and Environmental factor. PNG was found to be the best fuel, having an EEE impact factor of 0.06 and LDO is the worst, having an EEE impact factor of 0.43. A case study was also carried out to convert a boiler from HSD‐fired to PNG‐fired, which was found to be very encouraging with a payback period of approximately 1 year. The IRR also calculated, it was around 120% making it very appealing to invest for a good financial gain. This can be used as a reference and guiding document for the industries to take decisions for fuel switching and achieve better sustainability by implementing this initiative.
Recovery of auditory evoked response attentional gain modulation following the first psychotic episode indexes improvements in symptom severity
Authors: Coffman Brian A. , Curtis Mark T. , Sklar Alfredo , Seebold Dylan , Salisbury Dean F. 
Published: April 2023

AbstractAttentional control of auditory N100/M100 gain is reduced in individuals with first‐episode psychosis (FEP). Persistent problems with executive modulation of auditory sensory activity may impact multiple aspects of psychosis. As a follow‐up to our prior work reporting deficits in attentional M100 gain modulation in auditory cortex, we examined changes in M100 gain modulation longitudinally, and further examined relationships between auditory M100 and symptoms of psychosis. We compared auditory M100 in auditory sensory cortex between 21 FEP and 29 matched healthy participants and between timepoints separated by 220 ± 100 days. Magnetoencephalography data were recorded while participants alternately attended or ignored tones in an auditory oddball task. M100 was measured as the average of 80–140 ms post‐stimulus in source‐localized evoked responses within bilateral auditory cortex. Symptoms were assessed using the PANSS and PSYRATS. M100 amplitudes, attentional modulation of M100 amplitudes, and symptom severity all improved in FEP over time. Further, improvement in M100 modulation correlated with improvements in negative symptoms (PANSS) as well as physical, cognitive, and emotional components of hallucinations (PSYRATS). Conversely, improvements in the overall size of the M100, rather than the difference between active and passive M100 amplitudes, were related to worsening of positive symptoms (PANSS) and physical components of hallucinations. Results indicate a link between symptoms (particularly auditory hallucinations) and auditory cortex neurophysiology in FEP, where auditory attention and auditory sensation have opposed relationships to symptom change. These findings may inform current models of psychosis etiology and could provide nonpharmaceutical avenues for early intervention.
Heat‐Up Process: Road to Synthesizing Monodisperse Nanoparticles
Authors: Kim Byung Hyo , Ko Wonjae , Kim Jeong Hyun , Georgiou Joanna S. , Bootharaju Megalamane S. , Park Jongnam , Hyeon Taeghwan 
Published: April 2023

AbstractLarge‐scale synthesis of monodisperse nanoparticles is highly desirable for practical applications of nanoparticles in various fields of emerging technology. Among colloidal synthetic routes of monodisperse nanoparticles, heat‐up process, which involves a gradual heating of precursor solution in a batch reactor, has received utmost interest after its successful size‐controlled synthesis of various kinds of nanoparticles. In this essay, we discuss the fundamental research regarding the synthesis of monodisperse nanoparticles and describe how researchers developed the heat‐up process. The mechanistic insights into this synthetic method and the discovery of size‐dependent properties of monodisperse nanoparticles are also presented. We further emphasize its great impacts on utilizing monodisperse nanoparticles synthesized via the heat‐up process for biomedical technology, energy conversion and storage devices, as well as electronic and optoelectronic devices.
Effect of static tensile stress on enzymatic degradation of poly(glycerol sebacate)
Authors: Wu Zebin , Wang Lizhen , Fan Yubo 
Published: April 2023

AbstractPoly(glycerol sebacate) (PGS) is an excellent scaffold material in tissue engineering due to good biocompatibility and tunable mechanical properties. The degradation properties of PGS have been primarily explored in static phosphate buffer solution or enzyme solution. It is vital to understand how the tensile stress affect the degradation rate. In this study, PGS was synthetized by melt polycondensation and its properties were characterized. Then an in vitro degradation device which could provide different constant tensile stresses was carefully designed and established, and the enzymatic degradation of PGS was tested under 0–150 kPa at 37°C. It was found that holes of PGS surface arranged almost parallel to each other and perpendicular to the direction of tensile stresses at 100 kPa and 150 kPa after 2–4 days degradation. After 8 days degradation, the ultimate tensile strength (UTS) of PGS at 150 kPa was 0.28 MPa and the elastic modulus was 1.11 MPa, while the UTS of PGS was 0.44 MPa and the elastic modulus was 1.63 MPa before degradation, both of them have significant differences. Hence, the tensile stress and degradation time were proportional to the appear time and size of holes, leading to the decrease of mass loss, UTS and elastic modulus. The relationship between stress and PGS degradation rates was quantitatively described through our degradation experiments, providing guidance for suitable PGS applications in the future.
Antiandrogens for the treatment of COVID‐19 patients: A meta‐analysis of randomized controlled trials
Authors: Cheema Huzaifa Ahmad , Rehman Aqeeb Ur , Elrashedy Asmaa Ahmed , Mohsin Aleenah , Shahid Abia , Ehsan Muhammad , Ayyan Muhammad , Ismail Heba , Almas Talal 
Published: April 2023

AbstractAntiandrogens may carry a potential benefit as a therapeutic agent against COVID‐19. However, studies have been yielding mixed results, thus hindering any objective recommendations. This necessitates a quantitative synthesis of data to quantify the benefits of antiandrogens. We systematically searched PubMed/MEDLINE, Cochrane Library, clinical trial registers, and reference lists of included studies to identify relevant randomized controlled trials (RCTs). Results from the trials were pooled using a random‐effects model and outcomes were reported as risk ratios (RR) and mean differences (MDs) with 95% confidence intervals (CIs). Fourteen RCTs with a total sample size of 2593 patients were included. Antiandrogens yielded a significant mortality benefit (RR 0.37; 95% CI; 0.25–0.55). However, on subgroup analysis, only proxalutamide/enzalutamide and sabizabulin were found to significantly reduce mortality (RR 0.22, 95% CI: 0.16–0.30 and RR 0.42, 95% CI: 0.26–0.68, respectively), while aldosterone receptor antagonists and antigonadotropins did not show any benefit. No significant between‐group difference was found in the early or late initiation of therapy. Antiandrogens also reduced hospitalizations and the duration of hospital stay, and improved recovery rates. Proxalutamide and sabizabulin may be effective against COVID‐19, however, further large‐scale trials are needed to confirm these findings.
Proinflammatory mediators in lipid emulsions and parenteral nutrition–associated liver disease: Review of leading factors
Authors: Driscoll David F. 
Published: April 2023

AbstractLipid injectable emulsions have been in clinical use for over 60 years. The first product launched was Intralipid, which consisted of an emulsion of soybean oil in water for intravenous administration. It was a key source of essential fatty acids and an alternative source of energy for patients with gastrointestinal dysfunction requiring long‐term parenteral nutrition. With clinical experience, a condition known as parenteral nutrition–associated liver disease (PNALD), or intestinal failure–associated liver disease (IFALD), was observed, with a focus on carbohydrate and fat energy. Modifying the daily doses and infusion rates had some salutary effects, but PNALD persisted. Subsequently, on closer inspection of the fatty acids profile and phytosterol concentrations, degradation products arising from chemical and physical stability issues of the available lipid injectable emulsions were implicated. Recently, the US Food and Drug Administration convened an online workshop entitled “The Role of Phytosterols in PNALD/IFALD,” with an emphasis on (1) the multifactorial pathophysiology of PNALD/IFALD, (2) risk associated with phytosterols, and (3) regulatory history. The scope of this review includes the multifactorial pathophysiology of PNALD/IFALD as it relates to the pharmaceutical aspects of the various lipid injectable emulsions on the market, with respect to potential proinflammatory components, as well as physical and chemical stability issues that may also affect products' safe intravenous administration to patients.
Prognostic value of a composite outcome measure for periodontal stability following periodontal regenerative treatment: A retrospective analysis at 4 years
Authors: Simonelli Anna , Farina Roberto , Minenna Luigi , Tomasi Cristiano , Trombelli Leonardo 
Published: April 2023

AbstractBackgroundRecently, a composite outcome measure (COM) was proposed to describe the short‐term results of periodontal regenerative treatment. The present retrospective study aimed at evaluating the prognostic value of COM on clinical attachment level (CAL) change over a 4‐year period of supportive periodontal care (SPC).MethodsSeventy‐four intraosseous defects in 59 patients were evaluated at 6 months and 4 years following regenerative treatment. Based on 6‐month CAL change and probing depth (PD), defects were classified as: COM1 (CAL gain ≥3 mm, PD ≤4 mm); COM2 (CAL gain <3 mm, PD ≤4 mm); COM3 (CAL gain ≥3 mm, PD >4 mm); or COM4 (CAL gain <3 mm, PD >4 mm). COM groups were compared for “stability” (i.e., CAL gain, no change in CAL or CAL loss <1 mm) at 4 years. Also, groups were compared for mean change in PD and CAL, need for surgical retreatment, and tooth survival.ResultsAt 4 years, the proportion of stable defects in COM1, COM2, COM3, and COM4 group was 69.2%, 75%, 50%, and 28.6%, respectively, with a substantially higher probability for a defect to show stability for COM1, COM2, and COM3 compared with COM4 (odds ratio 4.6, 9.1, and 2.4, respectively). Although higher prevalence of surgical reinterventions and lower tooth survival were observed in COM4, no significant differences were detected among COM groups.ConclusionsCOM may be of value in predicting CAL change at sites undergoing SPC following periodontal regenerative surgery. Studies on larger cohorts, however, are needed to substantiate the present findings.
A novel protocol for quantitative determination of 1,4‐dioxane in finished cleaning products
Authors: Palumbo Brian , Conrad‐Vlasak Deena , Stanton Kathleen 
Published: April 2023

AbstractA novel method to quantify 1,4‐dioxane in finished cleaning products using headspace gas chromatograph with mass spectrometry (HS GC/MS), single ion monitoring, and a fully deuterated internal standard has been developed. The method generates very linear calibration curves with a R2 of at least 0.99, excellent accuracy with spike/recovery of 97%–102%, and effective precision of 1%–7%RSD for different cleaning products. The method also produces an instrument limit of quantitation (LOQ) of <20 ppb, and sample LOQ of <100 ppb. The method robustness was demonstrated with a ten‐lab round‐robin exercise that showed that even with some unexpected deviations from the method, excellent analytical results were obtained from the different labs. This new method will be valuable to evaluate consumer products impacted by government regulation to limit 1,4‐dioxane concentrations in complex matrices.
Amino acid carbon isotope fingerprints are unique among eukaryotic microalgal taxonomic groups
Authors: Stahl Angela R. , Rynearson Tatiana A. , McMahon Kelton W. 
Published: April 2023

AbstractEukaryotic microalgae play critical roles in the structure and function of marine food webs. The contribution of microalgae to food webs can be tracked using compound‐specific isotope analysis of amino acids (CSIA‐AA). Previous CSIA‐AA studies have defined eukaryotic microalgae as a single functional group in food web mixing models, despite their vast taxonomic and ecological diversity. Using controlled cultures, this work characterizes the amino acid δ13C (δ13CAA) fingerprints—a multivariate metric of amino acid carbon isotope values—of four major groups of eukaryotic microalgae: diatoms, dinoflagellates, raphidophytes, and prasinophytes. We found excellent separation of essential amino acid δ13C (δ13CEAA) fingerprints among four microalgal groups (mean posterior probability reclassification of 99.2 ± 2.9%). We also quantified temperature effects, a primary driver of microalgal bulk carbon isotope variability, on the fidelity of δ13CAA fingerprints. A 10°C range in temperature conditions did not have significant impacts on variance in δ13CAA values or the diagnostic microalgal δ13CEAA fingerprints. These δ13CEAA fingerprints were used to identify primary producers at the base of food webs supporting consumers in two contrasting systems: (1) penguins feeding in a diatom‐based food web and (2) mixotrophic corals receiving amino acids directly from autotrophic endosymbiotic dinoflagellates and indirectly from water column diatoms, prasinophytes, and cyanobacteria, likely via heterotrophic feeding on zooplankton. The increased taxonomic specificity of CSIA‐AA fingerprints developed here will greatly improve future efforts to reconstruct the contribution of diverse eukaryotic microalgae to the sources and cycling of organic matter in food web dynamics and biogeochemical cycling studies.
A Novel Strategy as a Potential Rapid Therapy Modality in the Treatment of Corneal Ulcers: Fluconazole/Vancomycin Dual Drug‐Loaded Nanofibrous Patches
Authors: Cesur Sumeyye , Ilhan Elif , Pilavci Esra , Sulutas Rabia Betul , Gurboga Merve , Bingol Ozakpinar Ozlem , Kaya Elif , Heljak Marcin , Bosgelmez Tinaz Gulgun , Oktar Faik Nuzhet , Gunduz Oguzhan , Kijeńska‐Gawrońska Ewa 
Published: April 2023

AbstractCorneal ulcer, which is brought on by a breach in the epithelial barrier, is a dangerous infection of the avascular corneal stroma. New treatment strategies are needed, suppressing the aggressive nature of the disease and including a combination of different drugs. In this study, vancomycin (VAN) and fluconazole (FLU) dual‐drug loaded dual‐layered polyvinyl alcohol and gelatin (PVA/GEL) nanofibrous patches are produced by electrospinning. Scanning electron microscopy (SEM) images show smooth surfaces are obtained for both pure and drug‐loaded nanofibrous patches. The tensile test results report that loading the FLU and VAN separately into the PVA/GEL patches decrease both the tensile strength and elongation at break and it is further reduced when combining two drug‐loaded layers in one patch. According to drug release results, the FLU and VAN‐loaded nanofibrous patches show a controlled release profile extending up to 96 h. Moreover, PVA/GEL/FLU, PVA/GEL/VAN, and PVA/GEL/FLU/VAN nanofibrous patches display significant antimicrobial activity against Candida albicans and Staphylococcus aureus. SEM, 4'‐6diamidynofenyloindol (DAPI) staining, and 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay show that PVA/FLU and PVA/GEL/FLU/VAN nanofibrous patches have a superior effect on NIH3T3 cell spreading and proliferation. The novelty of this study lays in the development of a potential dual drug rapid treatment for corneal ulcers of aggressive nature.
Retracted: A Photoclick Thiol‐Ene Collagen‐Based Hydrogel Platform for Skeletal Muscle Tissue Engineering
Authors: Holmes Roisin , Yang Xuebin B. , Wood David J. , Tronci Giuseppe 
Published: April 2023

AbstractUV‐cured collagen‐based hydrogels hold promise in skeletal muscle regeneration due to their soft elastic properties and porous architecture. However, the complex triple helix conformation of collagen and environmental conditions, i.e., molecular oxygen, pose risks to reaction controllability, wet‐state integrity, and reproducibility. To address this challenge, a photoclick hydrogel platform is presented through an oxygen‐insensitive thiol‐ene reaction between 2‐iminothiolane (2IT)‐functionalized type I collagen and multiarm, nonhomopolymerizable norbornene‐terminated polyethylene glycol (PEG). UV‐induced network formation is demonstrated by oscillatory time sweeps on the reacting thiol‐ene mixture, so that significantly increased storage moduli are measured and adjusted depending on the photoinitiator concentration. Variations in PEG functionality (4‐arm and 8‐arm) and PEG content generate hydrogels with skeletal muscle native stiffness (Ec = 1.3 ± 0.2‒11.5 ± 0.9 kPa), diffusion‐controlled swelling behavior and erosion‐driven degradability. In vitro, no cytotoxic effect is detected on C2C12 murine myoblasts, while myogenic differentiation is successfully accomplished on hydrogel‐seeded cells in then low serum culture medium. In vivo, 7 d subcutaneous implantation of selected thiol‐ene hydrogel in rats reveal higher cell infiltration, blood vessel formation, and denser tissue interface compared to a clinical gold standard collagen matrix (Mucograft, a trademark of Geistlich Biomaterials). These results, therefore, support the applicability and further development of this hydrogel platform for skeletal muscle regeneration.
Consumer–brand relationships and social distance: A construal level theory perspective
Authors: Luan Jing , Filieri Raffaele , Xiao Jie , Sun Yue 
Published: April 2023

AbstractBrands are increasingly struggling to establish and maintain strong relationships with their customers. But such relationship status is rare, and consumers are often relationship‐averse or satisfied with the relationship status quo. Drawing upon construal level theory (CLT) and consumer–brand relationship (CBR) literature, this study provides empirical support for the connection between CBRs and social distance and demonstrates that changes in CBRs foster variation of consumers' preferences to primary and secondary product features, which reflects their varying construal levels and consumer–brand social distances (study 1). Furthermore, we assessed whether the congruency between consumer–brand social distance and construal levels can contribute to more favorable product evaluations. Studies 2 and 3 reveal that when consumers are socially close to brands, product attributes (low‐level construal) exert a higher impact on product assessments, whereas when consumers are socially distant from the brand, price (high‐level construal) exerts a greater impact on product evaluations. Additionally, unlike the common belief that high prices lead to higher perceived quality, our findings suggest that a positive perception of a product attribute for low‐priced products leads to more favorable product evaluations. These results indicate that marketers can nurture existing CBRs for developing their communication strategy to achieve better consumer evaluations.
Does competition increase advertising?
Authors: Lai Tat‐kei , Ng Travis 
Published: April 2023

AbstractIn the Milgrom‐Roberts's advertising model, introducing the possibility to die before customers' repurchase alters the firm's advertising incentive to signal hidden product quality. Two opposing forces result, one mechanical and the other strategic. Depending on their relative strengths, the equilibrium advertising can either rise or fall. To the extent that competition threatens firms' survival, our result explains the mixed findings on the causal effects of competition on advertising. Introducing firm deaths in their model offers a new test of whether advertising signals quality, still an unsettled empirical question since Nelson first articulates advertising as a signal in 1974.
Analysis of GJB2 gene mutations spectrum and the characteristics of individuals with c.109G>A in Western Guangdong
Authors: Liang Shaoming , Li Weihong , Chen Zhichao , Yuan Shimin , Wang Zhao 
Published: April 2023

AbstractBackgroundGJB2 mutations are among the most important causes of deafness, and their prevalence varies greatly among different countries and ethnic groups. This study aimed to determine the pathogenic mutation spectrum of GJB2 in patients with nonsyndromic hearing loss (NSHL) in Western Guangdong and to explore the pathogenic characteristics of the c.109G>A locus.MethodsIn total, 97 NSHL patients and 212 normal controls (NC) were included in this study. Genetic sequencing analyses were performed on GJB2.ResultsIn the NSHL group, the main pathogenic mutations in GJB2 were as follows: c.109G>A, c.235delC, and c.299_300delAT with allele frequencies of 9.28%, 4.12%, and 2.06%, respectively. c.109G>A was the most frequently detected pathogenic mutation in this region. In the NC group, the allele frequency of c.109G>A among 30–50 years old subjects was markedly lower than that among 0–30 years old subjects (5.31% vs. 11.11%, p < 0.05).ConclusionWe found the pathogenic mutation spectrum of GJB2 in this region and showed that c.109G>A was the most common GJB2 mutation with unique characteristics, such as clinical phenotypic heterogeneity and delayed onset. Therefore, the c.109G>A mutation should be considered as an essential marker for routine genetic assessment of deafness, which can also be beneficial for preventing deafness.