bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data on vegetation across forest edges from the FERN (Forest Edge Research Network)
Authors: Harper Karen A. , Gray Logan , Macdonald S. Ellen , Lesieur Daniel , DeFields Danielle , Dodonov Pavel , Franklin Caroline Mary Adrianne , Haughian Sean R. , Mascarúa López Liliana , Heathcote Alexandra , Jager Krista , Yang Renee , Angelidis Christine , Braga Andreza Lanza , Butler Wendy , Coley Sarah , Kornelsen Jonathan M. E. , Murphy Liam , Pelton Julia , Recco Everton Viotto , de Oliveira Xavier Rafael , Wilson Iain , Ribeiro Milton C. , da Silva Matos Dalva Maria , Bergeron Yves 
Published: May 2023

AbstractMany studies have focused on vegetation across forest edges to study impacts of edges created by human activities on forest structure and composition, or patterns of vegetation at inherent natural edges. Our objective was to create a database of plant‐related variables across different types of edges from various studies (mainly from across Canada, but also in Brazil and Belize) to facilitate edge research. We compiled data on vegetation along more than 300 transects perpendicular to forest edges adjacent to clear‐cuts, burned areas, bogs, lakes, barrens, insect disturbances, and riparian areas from 24 studies conducted over the past three decades. Data were compiled for more than 400 plant species and forest structure variables (e.g., trees, logs, canopy cover). All data were collected with a similar sampling design of quadrats along transects perpendicular to forest edges, but with varying numbers of transects and quadrats, and distances from the edge. The purpose for most of the studies was either to determine the distance of edge influence (edge width) or to explore the pattern of vegetation along the edge to interior gradient. We provide data tables for the cover of plant species and functional groups, the species and size of live and dead trees, the density of saplings, maximum height of functional groups and shrub species, and the cover of functional groups at different heights (vertical distribution of vegetation). The Forest Edge Research Network (FERN) database provides extensive data on many variables that can be used for further study including meta‐analyses and can assist in answering questions important to conservation efforts (e.g., how is distance of edge influence from created edges affected by different factors?). We plan to expand this database with subsequent studies from the authors and we invite others to contribute to make this a more global database. The data are released under a CC0 license. When using these data, we ask that you cite this data paper and any relevant publications listed in our metadata file. We also encourage you to contact the first author if you are planning to use or contribute to this database.
Does a history of population co‐occurrence predict plant performance, community productivity, or invasion resistance?
Authors: Agneray Alison C. , Forister Matthew L. , Parchman Thomas L. , Leger Elizabeth A. 
Published: May 2023

AbstractA history of species co‐occurrence in plant communities is hypothesized to lead to greater niche differentiation, more efficient resource partitioning, and more productive, resistant communities as a result of evolution in response to biotic interactions. A similar question can be asked of co‐occurring populations: do individual species or community responses differ when communities are founded with plants sharing a history of population co‐occurrence (sympatric) or originating from different locations (allopatric)? Using shrub, grass, and forb species from six locations in the western Great Basin, North America, we compared establishment, productivity, reproduction, phenology, and resistance to invaders for experimental communities with either sympatric or allopatric population associations. Each community type was planted with six taxa in outdoor mesocosms, measured over three growing seasons, and invaded with the annual grass Bromus tectorum in the final season. For most populations, the allopatric or sympatric status of neighbors was not important. However, in some cases, it was beneficial for some species from some locations to be planted with allopatric neighbors, while others benefited from sympatric neighbors, and some of these responses had large effects. For instance, the Elymus population that benefited the most from allopatry grew 50% larger with allopatric neighbors than in single origin mesocosms. This response affected invasion resistance, as B. tectorum biomass was strongly affected by productivity and phenology of Elymus spp., as well as Poa secunda. Our results demonstrate that, while community composition can affect plant performance in semi‐arid plant communities, assembling communities from sympatric populations is not sufficient to ensure high productivity and invasion resistance. Instead, we observed an idiosyncratic interaction between sampling effects and evolutionary history, with the potential for seed source of individual populations to have community‐level effects.
The Chemistry of Vanadium bis‐Phenolate NHC Complexes in Three Oxidation States
Authors: Neururer Florian R. , Leitner Daniel , Liu Shenyu , Wurst Klaus , Kopacka Holger , Seidl Michael , Hohloch Stephan 
Published: May 2023

AbstractTwenty‐one vanadium bis‐phenolate benzimidazolylidene complexes, spanning three oxidation states, have been investigated. Special emphasis is placed on their salt metathesis reactivity and the accessibility of the +IV oxidation state by reductive or oxidative routes, starting from vanadium(V) or vanadium(III) respectively. While the reductive route is highly dependent on the reducing agent and starting material used, the oxidative route gives clean access to vanadium(IV) dihalide complexes. The low‐valent vanadium(III) complexes are excellent precursors for salt metathesis reactions which lead to the isolation of a rare vanadium(III) NHC alkyl complex. All new complexes have been characterized by (paramagnetic) 1H NMR and 51V NMR, UV–VIS, IR and EPR spectroscopy as well as elemental analysis. Cyclic voltammetry has been performed in selected cases to study the influence of imido or phenolate supporting ligands towards the redox‐potential of the vanadium(V/IV) redox couple compared to the parent oxo‐chlorido complex A.
N‐Boc‐Protected α‐Amino Acids by 1,3‐Migratory Nitrene C(sp3)−H Insertion
Authors: Zhou Bing , Ye Chen‐Xi , Meggers Eric 
Published: May 2023

AbstractN‐Boc‐protected α‐amino acids are synthesized in two steps from linear or branched carboxylic acid feedstocks. In the first step, the carboxylic acid is coupled with tert‐butyl aminocarbonate (BocNHOH) to generate azanyl ester (acyloxycarbamate) RCO2NHBoc. In the second step, this azanyl ester undergoes a stereocontrolled iron‐catalyzed 1,3‐nitrogen migration to generate the N‐Boc‐protected non‐racemic α‐amino acid. This straightforward protocol is applicable to the catalytic asymmetric synthesis of α‐monosubstituted α‐amino acids with aryl, alkenyl, and alkyl side chains. Furthermore, α,α‐disubstituted α‐amino acids are accessible in an enantioconvergent fashion from racemic carboxylic acids. The new method is also advantageous for the synthesis of α‐deuterated α‐amino acids. N‐Boc‐protected α‐amino acids synthesized using this two‐step protocol are ready‐to‐use building blocks.
CO2‐Enhanced Production and Synthesis of 2,5‐ Furandicarboxylic Acid under CO2 Flow through Henkel Reaction
Authors: Chang Po‐Hsun , Wong David Shan‐Hill , Ou John Di‐Yi , Pan Yung‐Tin , Jang Shi‐Shang 
Published: May 2023

AbstractThe present study investigated the preparation of 2,5‐furandicarboxylic acid (FDCA) via the Henkel reaction between furoic acid alkali metal salts and zinc chloride under a continuous CO2 flow at atmospheric pressure. The results obtained were compared with those of previous studies that used high‐pressure conditions or toxic cadmium catalysts. The pathways and rate‐determining steps of the reaction are revealed for the first time. Furthermore, the enhanced formation of FDCA through the promotion of carboxyl exchange and rearrangement during the reaction under a CO2 flow was examined. The CO2‐rich environment afforded a high FDCA yield of 86.30 %, which is the highest yield obtained to date using the Henkel reaction. The findings of this study offer economically improved conditions for large‐scale FDCA production.
Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring
Authors: Wang Jingfeng , Chen Duo , Huang Wanting , Yang Nianjun , Yuan Quan , Yang Yanbing 
Published: May 2023

AbstractNano‐biosensors that are composed of recognition molecules and nanomaterials have been extensively utilized in disease diagnosis, health management, and environmental monitoring. As a type of nano‐biosensors, molecular specificity field‐effect transistor (FET) biosensors with signal amplification capability exhibit prominent advantages including fast response speed, ease of miniaturization, and integration, promising their high sensitivity for molecules detection and identification. With intrinsic characteristics of high stability and structural tunability, aptamer has become one of the most commonly applied biological recognition units in the FET sensing fields. This review summarizes the recent progress of FET biosensors based on aptamer functionalized nanomaterials in medical diagnosis and environmental monitoring. The structure, sensing principles, preparation methods, and functionalization strategies of aptamer modified FET biosensors were comprehensively summarized. The relationship between structure and sensing performance of FET biosensors was reviewed. Furthermore, the challenges and future perspectives of FET biosensors were also discussed, so as to provide support for the future development of efficient healthcare management and environmental monitoring devices.
Microglial targeted therapy relieves cognitive impairment caused by Cntnap4 deficiency
Authors: Zhang Wenlong , Chen Huaqing , Ding Liuyan , Huang Jie , Zhang Mengran , Liu Yan , Ma Runfang , Zheng Shaohui , Gong Junwei , Piña‐Crespo Juan C. , Zhang Yunlong 
Published: May 2023

AbstractContactin‐associated protein‐like 4 (Cntnap4) is critical for GABAergic transmission in the brain. Impaired Cntnap4 function is implicated in neurological disorders, such as autism; however, the role of Cntnap4 on memory processing is poorly understood. Here, we demonstrate that hippocampal Cntnap4 deficiency in female mice manifests as impaired cognitive function and synaptic plasticity. The underlying mechanisms may involve effects on the pro‐inflammatory response resulting in dysfunctional GABAergic transmission and activated tryptophan metabolism. To efficiently and accurately inhibit the pro‐inflammatory reaction, we established a biomimetic microglial nanoparticle strategy to deliver FDA‐approved PLX3397 (termed MNPs@PLX). We show MNPs@PLX successfully penetrates the blood brain barrier and facilitates microglial‐targeted delivery of PLX3397. Furthermore, MNPs@PLX attenuates cognitive decline, dysfunctional synaptic plasticity, and pro‐inflammatory response in female heterozygous Cntnap4 knockout mice. Together, our findings show loss of Cntnap4 causes pro‐inflammatory cognitive decline that is effectively prevented by supplementation with microglia‐specific inhibitors; thus validating the targeting of microglial function as a therapeutic intervention in neurocognitive disorders.
Anthocyanins improve liver fibrosis in mice by regulating the autophagic flux level of hepatic stellate cells by mmu_circ_0000623
Authors: Du Jinhui , Liu Likun , Fan Haiqing , Yu Yue , Luo Yilin , Gu Fang , Yu Hui , Liao Xin 
Published: May 2023

AbstractLiver fibrosis is a key step in the progression of various chronic liver diseases to liver cirrhosis and even liver cancer, it is also an important link affecting prognosis. Therefore, this study aimed to investigate the therapeutic effect of anthocyanins on liver fibrosis and the molecular mechanism of mmu_circ_0000623 in anthocyanin therapy. In this study, CCL4 was used to build a mouse liver fibrosis model, and the treatment groups were treated with 100 and 200 mg/kg of anthocyanins daily by gavage. Liver fibrosis indicators, macrophage polarization markers, and liver injury markers were further detected by real‐time quantitative PCR (qRT‐PCR), western blotting (WB), and enzyme‐linked immunosorbent assay. Morphological verification of liver injury in different treatment groups was performed by histopathological method. A mouse hepatic stellate cell (HSC) model and a mouse liver fibrosis model were constructed to verify the expression of circ_0000623, miR‐351‐5p, and TFEB. Transfected with mRFP‐GFP‐LC3 to detect the autophagic flux of HSCs. We found that 100 mg/kg or 200 mg/kg of anthocyanins could significantly reduce the degree of liver fibrosis in mice. In addition, anthocyanins can inhibit the proliferation, activation, and migration ability of HSCs. circ_0000623 was lowly expressed in mice with liver fibrosis, and anthocyanin treatment could promote its increased expression. Further testing found that anthocyanins could reverse the blocked autophagic flux induced by PDGF or CCL4. This effect is achieved by regulating the expression of TFEB by competitive adsorption of miR‐351‐5p. Anthocyanins could treat liver fibrosis by modulating circ_0000623/miR‐351‐5p/TFEB‐mediated changes in HSC autophagic flux.
Analytical techniques for determination of heavy metal migration from different types of locally made plastic food packaging materials using ICP‐MS
Authors: Nguyen Van‐Trong , Linh Truong Thi Truc , Vo The‐Ky , Nguyen Quoc Hung , Van Thanh‐Khue 
Published: May 2023

AbstractPlastic food packaging is an essential element for customer convenience and the preservation of food quality. Nonetheless, heavy metals in the packaging materials, either intentionally or nonintentionally added, can be transferred to the food. Therefore, determining heavy metal contents in these packaging materials is essential. In this study, heavy metals, including Co, Ge, As, Cd, Sb, Pb, Al, and Zn from different intrinsic plastic food packaging materials were analyzed using the inductively coupled plasma‐mass spectrometry (ICP‐MS) method. Moreover, the migration of these elements into the environment was also investigated. This method is validated following the new technique's requirements, which include linearity range, accuracy, precision, the limit of detection (LOD), and the limit of quantitation (LOQ). The method has been suitably validated with the regression equation from the standards prepared in HNO3 1% v/v. The linear range was found to be ~1–20 ng mL−1 for Co, Ge, As, Cd, Sb, and Pb and 5–80 ng mL−1 for Al and Zn elements. The LODs are ~0.10, 0.25, 0.12, 0.13, 0.11, 0.12, 0.61, and 0.85 ng mL−1, and the LOQs are 0.33, 0.83, 0.40, 0.43, 0.36, 0.40, 2.01, and 2.81 ng mL−1 obtained for Co, Ge, As, Cd, Sb, Pb, Al, and Zn, respectively. In addition, the recovery percentages received ranged 85.4%–94.1% for Co, 82.6%–95.1% for Ge, 86.3%–97.9% for As, 87.3%–96.3% for Cd, 88.0%–104.4% for Sb, 96.3%–106.0% for Pb, 88.4%–104.0% for Al, and 95.1%–99.7% for Zn. Finally, the migration of these heavy metals from polypropylene (PP) and polystyrene (PS) into foodstuffs was also simulated according to EU legislation, showing that the most leached element was Zn, followed by Al and Pd, with the migration of ~8.38% and ~0.41%, and ~0.19%, respectively.
Cortical haemodynamic responses predict individual ability to recognise vocal emotions with uninformative pitch cues but do not distinguish different emotions
Authors: Moffat Ryssa , Başkent Deniz , Luke Robert , McAlpine David , Van Yper Lindsey 
Published: May 2023

AbstractWe investigated the cortical representation of emotional prosody in normal‐hearing listeners using functional near‐infrared spectroscopy (fNIRS) and behavioural assessments. Consistent with previous reports, listeners relied most heavily on F0 cues when recognizing emotion cues; performance was relatively poor—and highly variable between listeners—when only intensity and speech‐rate cues were available. Using fNIRS to image cortical activity to speech utterances containing natural and reduced prosodic cues, we found right superior temporal gyrus (STG) to be most sensitive to emotional prosody, but no emotion‐specific cortical activations, suggesting that while fNIRS might be suited to investigating cortical mechanisms supporting speech processing it is less suited to investigating cortical haemodynamic responses to individual vocal emotions. Manipulating emotional speech to render F0 cues less informative, we found the amplitude of the haemodynamic response in right STG to be significantly correlated with listeners' abilities to recognise vocal emotions with uninformative F0 cues. Specifically, listeners more able to assign emotions to speech with degraded F0 cues showed lower haemodynamic responses to these degraded signals. This suggests a potential objective measure of behavioural sensitivity to vocal emotions that might benefit neurodiverse populations less sensitive to emotional prosody or hearing‐impaired listeners, many of whom rely on listening technologies such as hearing aids and cochlear implants—neither of which restore, and often further degrade, the F0 cues essential to parsing emotional prosody conveyed in speech.
Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
Authors: Harada Hiroyuki , Kikuchi Masahiro , Asato Ryo , Hamaguchi Kiyomi , Tamaki Hisanobu , Mizuta Masanobu , Hori Ryusuke , Kojima Tsuyoshi , Honda Keigo , Tsujimura Takashi , Kumabe Yohei , Ichimaru Kazuyuki , Kitani Yoshiharu , Ushiro Koji , Kitamura Morimasa , Shinohara Shogo , Omori Koichi 
Published: May 2023

AbstractBackgroundSome oral squamous cell carcinoma (OSCC) cases are unaffected by smoking or drinking. This study aimed to clarify distinctive groups among OSCC patients and examine the characteristics of multiple primary carcinomas (MPCs).MethodsWe analyzed data from 970 patients. The patients were divided into three groups: all individuals <45 years (<45 y), smokers/drinkers ≥45 years (SD ≥45 y), and non‐smokers/non‐drinkers ≥45 years (NSND ≥45 y).ResultsTongue cancers were more common in the <45 y group than in the other groups (p < 0.001). The NSND ≥45 y group was significantly older and more likely to be female than the SD ≥45 y group (p < 0.001). MPCs in the upper aerodigestive tract were more common in men and smokers/drinkers, whereas women were at risk for multiple primary OSCCs (p = 0.022).ConclusionsThe “young tongue” and “elderly female” subgroups and characteristics of MPCs suggest carcinogenic factors of OSCC other than smoking and drinking.
Has the Rio Doce “time bomb” been defused? Using a weight-of-evidence approach to determine sediment quality
Authors: Abessa Denis , Burton G. Allen , Cervi Eduardo C. , Simpson Stuart L. , Stubblefield William , Ribeiro Caio C. , Cruz Ana C. F. , Kruger Gisele , Smith Ross 
Published: May 2023

Abstract
The Fundão mine tailings dam rupture of 2015, in the Rio Doce basin, Brazil, resulted in the deposition of tailings downstream of the dam. It has yet to be determined if metals associated with the tailings have contributed toxicity to organisms, burying a time bomb that could be ticking. Currently the data on toxicity to benthic and aquatic organisms have not been assessed sufficiently to allow an informed assessment using an approach based on weight-of-evidence. This study was conducted to ascertain if sediments at “hot spots” that received Fundão tailings reflected elevated concentrations of metals and if these concentrations were sufficient to result in toxicity to freshwater organisms. The lines-of-evidence considered included assessing metals concentrations in relation to sediment quality criteria, establishing biogeochemical characterizations, completing an evaluation of potential metal release upon resuspension to provide information on bioavailability, and identifying acute and chronic toxicity effects using sensitive native species for waters (water flea, Daphnia similis) and sediments (burrowing midge larvae, Chironomus sancticaroli). Only porewater concentrations of iron and manganese exceeded Brazilian surface water criteria, whereas most trace elements exhibited no enrichment or elevated environmental indexes. The concentrations of bioavailable metals were assessed to be low, and metal concentrations did not increase in the overlying water upon resuspension; rather, they decreased through time. Toxicity testing in resuspended waters and bulk sediments resulted in no acute or chronic toxicity to either benthic or aquatic species. The low metal bioavailability and absence of toxicity of the tailings-enriched sediments was attributed to the strong binding and rapid removal of potentially toxic metal ions caused by oxyhydroxides and particles in the presence of iron-rich particulates. The findings of these sediment hot-spot studies indicate the Fundão dam release of tailings more than six years ago is not causing the current release of toxic concentrations of metals into the freshwaters of the Rio Doce. Integr Environ Assess Manag 2024;20:148–158. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
GSK‐J4: An H3K27 histone demethylase inhibitor, as a potential anti‐cancer agent
Authors: Dalpatraj Nidhi , Naik Ankit , Thakur Noopur 
Published: May 2023

AbstractAberrant epigenetic modifications are emerging as potent drivers of tumor initiation and progression. The deregulation of H3K27me3 marks has shown to play an important role in cancer progression in several cancers. The H3K27me3 mark is associated with gene silencing. The reversible nature of these epigenetic aberrations makes them an important target for treating cancer. GSK‐J4 is a histone demethylase inhibitor that inhibits the JMJD3/UTX enzyme, which results in the upregulation of H3K27me3 levels. In this review, the anti‐cancer properties of GSK‐J4 have been summarized, the various molecular pathways targeted, in‐vivo studies, and drug combination studies in different cancer models. GSK‐J4 targeted pathways like apoptosis, cell cycle, invasion, migration, DNA damage repair, metabolism, oxidative stress, stemness, etc. GSK‐J4 is a promising candidate alone and in combination with other conventional anti‐cancer drugs against different cancer types.
Could the simultaneous persistence of greater cash holdings and interest‐bearing debts affect stock price crash risk?
Authors: Xu Pan , He Jun , Wang Daojuan , Johan Sofia A. , Lin Siwei 
Published: May 2023

AbstractWe study the impact of a unique financial anomaly—the simultaneous persistence of greater cash holdings and interest‐bearing debts (SP‐GCHID) on stock price. Due to institutional diversity and the nature of transition economies, high cash holdings do not always stem from precautionary motive as usually claimed but can be the result of cash misappropriation and debt manipulation by major shareholders. Analysing data from Chinese listed firms from 2010 to 2018, we find that SP‐GCHID is associated with a higher stock price crash risk (SPCR). It is more evident among firms with major shareholders pledging their shares and firms exposed to more external information monitoring. SP‐GCHID also affects SPCR through increasing real earnings management, further suggesting that major shareholders' misappropriation is the main reason for SP‐GCHID's adverse effect. These findings are also robust in a range of endogenous tests. To our knowledge, this study is the first to explore the economic consequences of SP‐GCHID.