bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Uncommon Good: Making Room for Radical Transition Imaginaries
Authors: SUNGU AZRA , ASHTON WESLYNNE , SHEA MAURA , FORLANO LAURA 
Published: January 2025

Public, social and community organizations are, in many locales, driving systems change toward social and economic equity, and environmental justice. But their visions for what achieving systems change should look like and what it will take to realize them are as diverse as the organizations pursuing them. Organizational coalitions are spaces where diverse groups converge to negotiate their distinct transition imaginaries: “collectively held, institutionally stabilized, and publicly performed visions of desirable futures” (Jasanoff and Kim 2015, 153) that suggest economic, social, and natural arrangements for the common good. These negotiations aim for reaching a shared purpose and set of goals that can guide the collective efforts. However, focusing on high‐level goals without contending with the diverse values and ethics that the collectives uphold can lead to a superficial and performative alignment that overshadows critical tensions, or worse, reinforcement of dominant ways of thinking that are at the root cause of the issues. As an alternative, manifesting diverse imaginaries can help uncover the diverse interpretations of futures suggested by high‐level transition goals, and move beyond the dominant narratives of progress towards more radical, yet actionable transition visions.This article proposes a design‐driven collaborative sensemaking approach for manifesting the diverse transition imaginaries in emerging coalitions as a means to create more inclusive and pluralistic transition visions. We utilize narratives as a mechanism through which designers can uncover the distinct imaginaries that drive the existing initiatives, understand the tensions between the values and ethics underpinning these imaginaries, and activate alternative imaginaries in collective negotiations of transitions. We propose that, by employing discourse analysis in combination with design tools, transition practitioners can more meaningfully engage with alternative value systems and mindsets.
Breaking the Wall of Engineering and Culture: Applied Qualitative Research in Software Companies of LATAM Industrial Sector
Authors: SUNIAGA SALVADOR 
Published: January 2025

This report condenses the learning of more than three years of ethnographies carried out in the Latin American industrial sector. We will rely mainly on the case of a Peruvian reseller company and local representative of a global 3D engineering software solution. The complete process of research proposal, demonstration of its advantages, resistances, methodology, findings, and application toward business strategies was executed between 2017 and 2020.For this research, a method called Techno‐Ethnographic Consulting was planned, which combines in‐depth interviews with business deliverables for informants, specifically designed to obtain qualitative data in B2B industrial companies of technological products and services when the researcher is also a technical expert.The researcher was a mechanical engineer with background in business anthropology and worked within the company as a member of the organization. The reseller business style is B2B, and its clients are industrial companies with design and manufacturing areas.
Optimal Task Allocation and Sequencing for Flight Test Based on a Memetic Algorithm With Lexicographic Optimisation
Authors: Tian Bei , Xiao Gang , Shen Yu , Jiang Xingwei 
Published: January 2025

ABSTRACTThe flight test plays an important role in the development of an aircraft. Currently, with the increasing complexity and higher validation requirements for aircraft, there is a crucial need to generate high‐quality flight test task schedules in an efficient way. This paper proposes a flight test task scheduling problem (FTTSP), which involves assigning suitable aircraft and executing the flight test tasks in a given order. Generally, the flight test duration (FTD) is the primary optimisation objective for the flight test task schedule, as it has a direct impact on aircraft development costs and the time to enter the market. In this study, the FTTSP not only considers FTD but also takes into account task transfer consumption (TTC). A mixed‐integer linear programming mathematical model is first formulated to describe the FTTSP characteristics with the optimisation of the FTD and the TTC in a sequential manner. Then, a memetic algorithm with lexicographic optimisation (MALO) is proposed, which can efficiently obtain a high‐quality solution and ensure that the most critical metric can be fully optimised. In MALO, a two‐vector encoding and a task logic relationship repair mechanism based on the binary tree are established. An idle time insertion decoding method is designed to improve the aircraft utilisation rate. In addition to the selection, crossover and mutation operators, a local search operator is designed to enhance the solution quality. Finally, the full‐scale test instances are generated for the FTTSP to evaluate the algorithm's performance. The numerical results demonstrate the effectiveness and competitiveness of the MALO in generating a high‐quality schedule for flight test tasks.
Industry 4.0 and the Importance of an Ecosystem‐Based Approach: An Empirical Investigation Based on a Mixed‐Method Analysis
Authors: Boyer James 
Published: January 2025

ABSTRACTThis paper will analyze the role of the innovation ecosystem (IES) in the industry implementation process of Industry 4.0 (I4.0) at company level. Based on a mixed‐method analysis using econometric models and content analysis, we have investigated the implementation process of industry 4.0‐enabling technologies of 123 manufacturing companies in the Hauts‐de‐France region of France. We have showed that the implementation process of industry 4.0‐enabling technologies is facilitated by the complexities of relationships between actors, complementarities among actors, particularly between start‐ups and others ecosystem stakeholders, and the role of regional policies (innovation support). Our quantitative results confirm that complex relationships with heterogenous actors within an IES positively affect the implementation process of Industry 4.0 at company level. While our qualitative analysis has showed that business‐to‐business relationships were decisive, our quantitative analysis has gone further and has showed that the more a given company develops diverse forms of relationships with other companies within the IES, the higher the level of I4.0 implementation‐enabling technologies there are in the company. Both qualitative and quantitative results demonstrate the importance of university‐industry linkage and of business incubators for the I4.0 implementation process, in enabling technologies at company level. A further result that completes our econometric study is the clear identification by company managers of the key role played by collaborative innovation projects and by start‐ups as providers of new solutions in fostering their I4.0 technological development. Therefore, our research calls for an ecosystem‐based approach to fostering I4.0 implementation at company level.
Low serum 25‐hydroxyvitamin D levels in migraine are not related to headache frequency: A case‐control study in patients with high‐frequency/chronic migraine
Authors: Haro Marina , Gárate Gabriel , Hernández José Luis , Olmos José Manuel , Muñoz María , González‐Quintanilla Vicente , Pascual Julio 
Published: January 2025

AbstractBackgroundSerum 25‐hydroxyvitamin D (25[OH]D) concentrations have been shown to be low in patients with migraine, but results are controversial regarding the current role of vitamin D in migraine severity. Using a case–control design, we aimed to evaluate serum 25(OH)D levels in a group of females with high‐frequency episodic migraine/chronic migraine (HF/CM) and analyze its association with headache frequency and serum calcitonin gene–related peptide (CGRP) levels.MethodsSerum 25(OH)D levels were measured in 97 females with HF/CM (age 48.9 ± 9.4 years) and 146 healthy females (47.4 ± 8.1 years). Participants taking vitamin D supplements were excluded. Serum concentrations of 25(OH)D were determined by electrochemiluminescence (Roche, Germany), and CGRP levels were measured by enzyme‐linked immunosorbent assay (Abbexa, UK).ResultsMean 25(OH)D levels in females with HF/CM (median [interquartile range] 19.0 [13.0–24.5] ng/mL) were below the values considered for insufficiency or deficiency and significantly lower than controls (25.0 [19–29.8] ng/mL; p < 0.0001). Fifty (51.5%) patients with HF/CM had levels below 20 ng/mL. There was no significant association between vitamin D levels and monthly headache days (Spearman's rank correlation coefficient [rho]: −0.086; p = 0.404) or with serum α (rho: 0.114; p = 0.267) and β‐CGRP (rho: 0.113; p = 0.276) levels. Serum 25(OH)D levels in females with HF/CM with a minimum daily sunlight exposure were significantly higher than those without (23.0 [15.0–26.0] ng/mL vs. 14.0 [10.0–20.0] ng/mL; p < 0.001). Females with HF/CM who performed exercise had higher, albeit not significant, plasma 25(OH)D levels than those who did not (21.0 [15.5–28.0] ng/mL vs. 16.5 [12.0–24.0] ng/mL; p = 0.059).ConclusionsSerum concentrations of 25(OH)D were low in many patients with HF/CM. Because there was no correlation with migraine frequency or serum CGRP levels, this deficiency seems to be a direct consequence of the migraine impact. Our data do not support either a relationship of 25(OH)D levels with migraine severity or the use of vitamin D supplements as a specific migraine treatment, although further studies are needed.
Association of C4 Null Alleles and Persistently Low C4 in Asian Indian Patients With Systemic Lupus Erythematosus
Authors: Jeevanagi Sachin R. , Mehta Pankti , Aaron Rekha , Danda Debashish , Danda Sumita , Kabeerdoss Jayakanthan 
Published: January 2025

ABSTRACTThe association between heterozygous C4 deficiency and systemic lupus erythematosus (SLE) is unclear. There is a lack of data in South Asian Indians on any possible association of C4A and C4B null alleles with lupus. We aimed to study the prevalence of C4A and C4B null alleles in a cohort of SLE patients with persistently low C4 levels compared to healthy controls (HC). Patients with SLE and HC were recruited for this prospective observational study. C4 (C4AQ and C4BQ) polymorphisms were tested using a touch‐down polymerase chain reaction protocol. One hundred and three SLE patients and 103 HC were included in the study. Persistently low C4 levels were observed in 25 (23.6%) of SLE. The frequency of C4A and C4B null alleles was similarly distributed across SLE and HC (4% and 3.8%, respectively). Univariate analysis showed a low age, higher proportion of elevated dsDNA, and higher positive anti‐SSA (Sjogren's syndrome‐related antigen A) antibodies at presentation were associated in SLE patients with the null allele group on comparison without the null allele group. However, these associations did not persist in the multivariate analysis. In conclusion, C4 null allele frequency was similar in SLE and HC. No characteristic associations were observed in SLE with C4 null alleles was observed. Therefore, C4 null allele is an unlikely explanation for persistently low C4 in South Indian Asian patients with lupus.
Replication Study and Meta‐Analysis of the Contribution of Seven Genetic Polymorphisms in Immune‐Related Genes to the Risk of Gastric and Colorectal Cancers
Authors: Zhou Weiguang , Yuan Siqi , Kang Wenqiang , Deng Xiangyuan , Zhou Hang , Ruan Jiangyi , Feng Xianhong , Qi Meifang , Chen Bifeng 
Published: January 2025

ABSTRACTRecently, it has been realized that immune processes participate in the pathogenesis of human cancers. A large number of genetic polymorphisms in immune‐related genes have been extensively examined for their roles in the susceptibility of gastric cancer (GC) and colorectal cancer (CRC), including IL4 gene rs2070874, IL4RA gene rs1801275, IL18 gene rs187238, IL18RAP gene rs917997, IL17A gene rs8193036, IL23R gene rs1884444 and IL23R gene rs10889677. However, there is no consistent conclusion, which calls for further research. In this case–control study, these 7 genetic polymorphisms were genotyped by Sanger sequencing in a total of 1247 patients with cancer (GC/CRC: 460/787) and 800 healthy individuals. A total of 31 previous studies and our present study were included in this meta‐analysis. The case–control study revealed that in Hubei Chinese population, rs2070874, rs187238 and rs10889677 were significantly associated with CRC risk, whereas only rs917997 was significantly associated with GC risk. The meta‐analysis showed that rs2070874, rs917997, rs8193036 and rs1884444 were significantly associated with GC risk in Chinese population, whereas rs2070874 in total population, rs1801275 in Asian population and rs187238 in Chinese population were significantly associated with CRC risk. IL4 gene rs2070874, IL18RAP gene rs917997, IL17A gene rs8193036 and IL23R gene rs1884444 may serve as the susceptible factors for GC carcinogenesis in Chinese population. IL4 gene rs2070874 in total population, IL4RA gene rs1801275 in Asian population and IL18 gene rs187238 in Chinese population may be genetic biomarkers for CRC susceptibility.
Efficacy of Subcutaneous, Sublingual and Oral Immunotherapy for Allergens: A Comparative Study
Authors: Lisiecka Maria Zofia 
Published: January 2025

ABSTRACTThe purpose of this study was to compare the efficacy and safety of subcutaneous, sublingual, oral specific immunotherapy in patients who suffer from allergic conditions to pollen from trees, grasses and weeds, house dust mites and Alternaria alternata spores. A literature search was performed separately for each type of allergen and each administration route of the drug. As a result, it was found that all administration routes were quite effective. However, each type of immunotherapy was most effective for certain allergens. Subcutaneous and sublingual immunotherapy have proven effective for aeroallergens such as pollen from grass, trees, weeds and house dust mites. Despite this, subcutaneous immunotherapy had a number of disadvantages in the form of the duration of treatment and a greater prevalence of side effects. Some authors suggest that for allergies to house dust mites, the most effective method of immunotherapy was the subcutaneous method of administration, compared with sublingual and nasal. Sublingual therapy was safe enough for all types of allergens under study, however, to achieve the same effect as the subcutaneous method of administration. In addition, oral immunotherapy has been shown to be effective for food allergies with obvious symptoms of gastrointestinal disorders. In addition, oral immunotherapy is the only approved treatment for allergies in the elderly, due to the low risk of side effects. The time‐accelerated and dosage‐enhanced immunotherapy was also effective and safe. These data prove the effectiveness and safety of each administration route of specific allergens for specific immunotherapy in patients suffering from allergic rhinitis, bronchial asthma and even atopic dermatitis.
A qualitative exploration of the barriers and facilitators to early lower limb assessment and onward referral for specialist treatment for patients with venous ulceration
Authors: Bolton Saghdaoui Layla , Lampridou Smaragda , Davies Alun Huw , Onida Sarah , Wells Mary 
Published: January 2025

AbstractGuidance for venous leg ulceration (VLU) recommends compression therapy and early referral for specialist vascular assessment within two weeks. Few patients receive timely assessment and referral. Reasons for this are unclear. The aim of this work was to explore nurses' perceptions of the barriers and facilitators to early assessment of VLU and referral for specialist treatment. One‐to‐one semi‐structured interviews explored experiences caring for and referring patients with VLU to a vascular specialist. Maximum variation sampling and inductive thematic analysis were used. Eighteen nurses participated. Findings suggest junior nurses lack knowledge and confidence to care for VLU and often revert to a ‘task‐based’ approach, exacerbated by staff shortages and limited training. Because VLU occurs in the context of competing conditions and pressures, comprehensive assessments are missed, and the need for referral is not established or prioritised. Supporting patients to self‐manage is seen as a possible solution. Nurses reported disjointed pathways between primary and secondary care, compounded by poor MDT collaboration, ineffective communication systems and inadequate data sharing. Consequently, when the need for referral is established, communicating this between healthcare organisations is complex. Organisational and behavioural barriers impact nurses' ability to promote timely referral. Further exploration with patients and other healthcare professionals is needed.
Comparison of cell‐scaffold interactions in a biological and a synthetic wound matrix
Authors: Hong Joon Pio , Maitz Joanneke , Mörgelin Matthias 
Published: January 2025

AbstractWound healing is a central physiological process that restores the barrier properties of the skin after injury, comprising close coordination between several cell types (including fibroblasts and macrophages) in the wound bed. The complex mechanisms involved are executed and regulated by an equally complex, reciprocal signalling network involving numerous signalling molecules such as catabolic and anabolic inflammatory mediators (e.g., cytokines, chemokines). In chronic wound environments, the balance in the molecular signatures of inflammatory mediators is usually impaired. Thus, we compared the ability of a collagen‐based wound matrix against a synthetic wound matrix to attract fibroblasts and macrophages that deliver these signalling molecules. In particular, the balance between pro‐ and anti‐ inflammatory cytokine secretion was assessed. We found that the natural collagen‐based matrix was the most efficient adhesive substrate to recruit and activate fibroblasts and macrophages on its surface. These cells secreted a variety of cytokines, and the natural biomaterial exhibited a more balanced secretion of pro‐ and anti‐inflammatory mediators than the synthetic comparator. Thus, our study highlights the ability of native collagen matrices to modulate inflammatory mediator signatures in the wound bed, indicating that such devices may be beneficial for wound healing in the clinical setting.
Comparison between artificial dermis with split‐thickness skin graft and full‐thickness skin graft for reconstruction of joint‐involved burn wounds: A retrospective review from a tertiary burn centre
Authors: Yeh Jui‐Po , Lin Ko‐Chien 
Published: January 2025

AbstractWe aimed to compare the scar quality and recovery rate of joint activity for patients with joint‐involved burn injuries receiving either artificial dermis (AD) with split‐thickness skin graft (STSG) or full‐thickness skin graft (FTSG) for reconstruction. The primary outcomes were %skin graft (SG) take. Secondary outcomes included complications such as the infection rate and donor site morbidity, 12‐month scar quality evaluated using the Vancouver scar scale (VSS), recovery rate of joint activity and incidence of scar contracture requiring further revision. Twenty‐eight patients between 1 August 2021, and 1 August 2023, were enrolled. Twelve patients received AD‐STSG while the other 16 patients underwent FTSG for reconstruction. The median %SG take was 95.0% (interquartile range [IQR] 6.3%) and 96.0% (IQR 10.0%) for the AD‐STSG and FTSG groups (p = 0.71). The FTSG group had significantly better 12‐month scar quality (median VSS 4.0 [IQR 1.3] vs. 6.0 [IQR1.5], p < 0.01) and recovery rate of joint activity (median 82.5% [IQT 15.0%] vs. 70.0% [IQR 7.5%], p < 0.01) compared with AD‐STSG group. However, two patients in the FTSG group (12.5%) suffered partial wound dehiscence of the donor site, whereas no patients experienced donor site morbidity in the AD‐STSG group (p = 0.49). The incidence of scar contracture requiring further revision was 25.0% (3/12) in the AD‐STSG group and 12.5% (2/16) in the FTSG group (p = 0.62). In conclusion, AD‐STSG could be an alternative treatment over FTSG for larger joint‐involved burn wounds (>200 cm2) owing to lesser donor site morbidity with admissible cosmetic outcomes and functional recovery.
Early experience on injectable micronized putty type human‐derived acellular dermal matrix (ADM) in management of diabetic foot wounds in Singapore
Authors: Quah Alison Mei Fern , Ng Marcus Jia Ming , Zhang Li , Chan Yam Meng , Neo Shufen , Mak Malcolm , Hong Qiantai , Tan Glenn , Pan Ying , Yong Enming 
Published: January 2025

AbstractDiabetic foot wounds (DFW) are notoriously difficult to treat owing to poor vascularity, delayed healing and higher rates of infection. Human‐derived acellular dermal matrices (ADM) have been used in DFW treatment, utilizing a matrix scaffold for new tissue generation. We investigate the efficacy of a micronized injectable human‐derived ADM in the treatment of DFW. We retrospectively recruited 13 patients with diabetic foot wounds. Wounds were adequately debrided, and a micronized injectable ADM was applied. Wound sizes were recorded prior to treatment, at 2 and 4 weeks post‐treatment. The mean defect of wounds treated was 19.21 cm3. Our results showed a statistically significant reduction in wound size of 45% and 59% at 2 and 4 weeks post‐treatment, respectively (p < 0.01). ADM was also effective in infected DFW as 84% of our wounds had positive tissue cultures at the time of application. Micronized injectable ADM has proven to be an effective treatment for DFW. Advantages include a ready‐to‐use injectable, single‐stage treatment, minimal pain, mouldable matrix to fit any wound shape, allows for outpatient treatment and simple wound dressings.
The Role of RyR2 Mutations in Congenital Heart Diseases: Insights Into Cardiac Electrophysiological Mechanisms
Authors: Lv Tingting , Li Siyuan , Li Qing , Meng Lingbing , Yang Jing , Liu Lianfeng , Lv Changhua , Zhang Ping 
Published: January 2025

ABSTRACTRyanodine receptor 2 (RyR2) protein, a calcium ion release channel in the sarcoplasmic reticulum (SR) of myocardial cells, plays a crucial role in regulating cardiac systolic and diastolic functions. Mutations in RyR2 and its dysfunction are implicated in various congenital heart diseases (CHDs). Studies have shown that mutations in the RYR2 gene, which encodes the RyR2 protein, are linked to several cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), calcium release deficiency syndrome (CRDS), and atrial fibrillation (AF). Additionally, RyR2 mutations have been associated with multiple genetic cardiomyopathies, such as left ventricular non‐compaction cardiomyopathy (LVNC), arrhythmogenic right ventricular cardiomyopathy (ARVC), hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). Through various cell and animal models, researchers have developed mutant RyR2 models demonstrated that these mutations often lead to calcium dysregulation, typically resulting in either a gain or loss of function. This comprehensive review delves into the current understanding of RyR2 mutations and their impact on cardiac electrophysiology, focusing on the molecular mechanisms linking these mutations to arrhythmias and cardiomyopathies—an essential step in advancing diagnostic and therapeutic strategies.
Long RP Tachycardia and Short RP Tachycardia: Is the Nodoventricular Pathway a Culprit or an Innocent Bystander?
Authors: Mizutani Akinobu , Okada Masato , Tanaka Koji , Tanaka Nobuaki , Nagashima Koichi , Scheinman Melvin M. 
Published: January 2025

ABSTRACTWe encountered a single case in which a transition between orthodromic reciprocating tachycardia with a concealed nodoventricular pathway and atrioventricular nodal reentrant tachycardia with a bystander nodoventricular pathway was observed.