bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic benefit of catheter ablation of atrial fibrillation in heart failure: An updated meta‐analysis of randomized controlled trials
Authors: Virk Sohaib A. , Hyun Karice , Brieger David , Sy Raymond W. 
Published: January 2023

AbstractBackgroundThe prognostic role of catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) remains uncertain, with guideline recommendations largely based on a single trial. We conducted a meta‐analysis of randomized controlled trials (RCTs) assessing the prognostic impact of AF ablation in patients with HF.MethodsElectronic databases were searched for RCTs comparing ‘AF ablation’ versus ‘other care’ (medical therapy and/or atrioventricular node ablation with pacing) in patients with HF. Primary endpoints were ≥1‐year mortality, HF hospitalization and change in left ventricular ejection fraction (LVEF). Meta‐analyses were performed using random‐effects modelling.ResultsNine RCTs (n = 1462) met inclusion criteria. Compared to ‘other care’, AF ablation significantly reduced ≥1‐year mortality (relative risk [RR] 0.65; 95% confidence intervals [CI], 0.49–0.87) and HF hospitalization (RR 0.64; 95% CI, 0.51–0.81). AF ablation demonstrated significantly greater improvement in LVEF (mean difference [MD] 5.4; 95% CI, 4.4–6.4), 6‐min walk test distance (MD 21.5 meters; 95% CI, 4.6–38.4) and quality of life as measured by Minnesota Living with Heart Failure Questionnaire score (MD 7.2; 95% CI, 2.8–11.7). Meta‐regression analyses showed the beneficial impact of AF ablation on LVEF was significantly blunted by higher prevalence of ischaemic cardiomyopathy.ConclusionsOur meta‐analysis demonstrates AF ablation is superior to ‘other care’ in improving mortality, HF hospitalization, LVEF and quality of life in patients with HF. However, the highly selected study populations in included RCTs and effect modification mediated by etiology of HF suggests these benefits do not uniformly apply across the HF population.
A mesh refinement method for low‐thrust orbit transfer problems
Authors: Zhou Hongyu , Bai Yuliang , Wang Xiaogang , Cui Naigang 
Published: January 2023

AbstractThis paper researches the fuel‐optimal geocentric orbit transfer problem using a low‐thrust, electric propulsion. First, the transfer trajectory is divided into N burn‐coast arcs via introducing (N−1) intermediate orbits between the initial and the target orbits. By restricting the time duration of each burn, the changes in orbital states caused by one time of ignition can be represented by a discrete velocity impulse; therefore, a considerable large N, a great many optimization variables, and a months and revolutions long trajectory will be calculated to solve the optimization problem. By proposing a new transfer coordinate system, the performance index is analytically calculated, and strict constraints derived from the continuous condition between adjacent orbits are removed from the mathematical optimization model. Meanwhile, an improved particle swarm optimization (PSO) method and a mesh refinement method are proposed to address the optimization problem. The mesh refinement algorithm begins with a simple bi‐impulse transfer problem, automatically increases/decreases N, and finally converges to the optimal solution. Numerical simulation shows the efficiency of the method with some classical and representative scenarios.
An adaptive observer design for denial‐of‐service attack detection in platoon
Authors: Zhang Xiaofei , Du Haiping , Jia Zhijuan , Cui Chi , Cheng Yage , Yan Yan 
Published: January 2023

AbstractDue to the increasing demand for autonomous driving, cyber‐attacks detection nowadays receives significant attention. Among several different types of attacks, Denial‐of‐Service (DoS) attacks can consume resources and cause the system under attack to stop responding, which can be considered a time delay model affecting the response of the attacked system. To detect the possible DoS attacks in Cooperative Adaptive Cruise Control platoon model, an adaptive observer design is proposed in this paper, where the time delay caused by DoS attacks can be fast and accurately estimated. To highlight the performance of the proposed adaptive observer, numerical simulations are applied and the performance is compared against the sliding mode observer in terms of the DoS attack time delay estimation convergence and accuracy.
Workplace accident analysis in the Algerian oil and gas industry
Authors: Zerrouki Hamza , Ghozlane Mohamed Djamel Eddine , Estrada Lugo Hector Diego , Patelli Edoardo 
Published: January 2023

AbstractA total of 42,032 workplace accidents were reported in 2021 by the Algerian National Social Insurance Fund for Salaried Workers in Algeria, of which 38,225 were accidents within the workplace and 3807 were related to traffic accidents or other reasons. Most of these accidents were recorded in the building and construction field, followed by the oil and gas company exploration and drilling, which comes at the forefront of the Sonatrach company. This study aims to analyze accidents in the workplace using quantitative and qualitative methods to determine the corresponding causes. Our study was carried out in collaboration with Sonatrach in south Algeria where information and reports on work accidents from years 2017 to 2021 were collected. Data acquired were classified and analyzed according to the location and time of the accident. Based on the results obtained, we found that the human factor was the main cause of most accidents due to nonrespect of safety procedures and lack of concentration of workers. The results of the analysis suggest implementation of a break time during the afternoon, avoiding long overtime hours, suspending work outside stations during high temperatures periods in July and August as well as suspending work when sandstorms appear in winter.
Robot‐assisted versus navigated transpedicular spine fusion: A comparative study
Authors: Romagna Alexander , Sperker Sarah , Lumenta Christianto , Tomasino Andre , Schwartz Christoph , Lehmberg Jens , Zausinger Stefan , Schul David 
Published: January 2023

AbstractBackgroundThe aim of this study was to compare the intraoperative and postoperative outcomes between a robot‐assisted versus a navigated transpedicular fusion technique.MethodsThis retrospective analysis included patients who underwent transpedicular posterior fusion of the spine due to trauma, pyogenic spondylodiscitis and osteoporosis. Surgery was done either with a robot‐assisted or a percutaneous navigated transpedicular fusion technique. The outcome analysis included the duration of surgery, the radiation exposure, the postoperative screw position and complications.ResultsA total of 60 patients were operated and 491 screws were analysed. No statistical difference was seen in the applied cumulative effective radiation dose per patient. The radiological assessment revealed a more accurate screw placement with robot assistance. A learning curve could be observed in robot‐assisted fusion.ConclusionRobot‐assisted and navigated transpedicular fusion techniques are both effective and safe. Robot‐assisted transpedicular spine fusion goes along with higher placement accuracy but its implementation needs an adequate learning curve.
Applying risk assessment methods to the sex trafficking process: A feasibility study
Authors: Laux Chad , Seigfried‐Spellar Kathryn C. , Guerra Laura Martínez , Lint Gianna S. 
Published: January 2023

AbstractSex trafficking is the fastest‐growing organized criminal activity. Trafficking organizations are driven by profit and provide a service due to existing demand. We examined the feasibility of applying risk assessment methods to understand the problem of sex trafficking from a systems perspective. Focusing on Indiana, we recruited and trained subject matter experts (SMEs) in risk assessment methodologies utilized in Six Sigma (SS); specifically Cause and Effect (C&E) Matrix and Failure Mode and Effects Analysis (FMEA). The research team developed a sex trafficking business process map (BPM) and prioritized activities by applying a C&E Matrix to identify the process steps with the potential for disruption. The most common failure modes (FMEA) identified by the SMEs included the trafficker or customer being caught followed by the victim being rescued. We conclude that an SS risk assessment approach is a viable framework in understanding the system of sex trafficking. Limitations and future research suggestions are discussed.
Identification of Subsurface Structures Using H/V Curves from Earthquake Recordings: Application to Seismic Stations in Switzerland
Authors: Chieppa Dario , Hobiger Manuel , Nagashima Fumiaki , Kawase Hiroshi , Fäh Donat 
Published: January 2023

AbstractWe performed a study to test the performances of the Hybrid Heuristic Search (HHS) algorithm (Nagashima et al. 2014) using earthquake recordings at 23 instrumented sites in Switzerland. The HHS algorithm is based on the diffuse field theory and estimates the P- and S-wave velocity profiles by inverting horizontal-to vertical spectral ratio (H/V) curves of earthquake recordings. In this study we inverted the H/V curves computed using the arrivals of local and regional earthquakes with a maximum local magnitude of 4.6. We compared the results of the inversion technique to the information available for each investigated site (e.g., site characterization analysis). Our results emphasize the importance of site characterization data for the definition of the parameter space in the near surface, and the potential to extend the investigated depth to much higher depths than the standard site characterization measurements. The additional constraints in the inversion are important to drive the inversion towards a unique solution. Our analysis confirms the potential of the HHS algorithm to invert the full earthquake H/V curve for subsurface investigation and its applicability to areas with low magnitude earthquakes. In addition, the HHS algorithm can be a useful technique to investigate deeper structures and extend the velocity profile to depths that are not resolved by classical site characterization techniques.
Sterile Punktion großer Gelenke
Authors: Labmayr Viktor , Eckhart Franz Josef , Smolle Maria , Klim Sebastian , Fischerauer Stefan Franz , Bernhardt Gerwin , Seibert Franz Josef 
Published: January 2023

Zusammenfassung
Ziel
Die Punktion großer Gelenke erfolgt einerseits zur Diagnostik und andererseits zur Behandlung von Gelenkspathologien. Mittels Punktion kann eine rasche Schmerzreduktion durch Entlastung von Ergüssen oder intraartikulären Hämatomen erfolgen. Das gewonnene Punktat erlaubt schon bei der Beschau mit dem freien Auge eine erste Einschätzung und in der Folge eine mikroskopisch-zytologische sowie mikrobiologische Befundung im Labor.

Indikationen
Die Punktion eines großen Gelenkes ist zur Diagnose und/oder Therapie bei entzündlichen, traumatischen oder postoperativen Gelenksveränderungen angezeigt. Diagnostische Punktionen dienen der Punktatgewinnung, der differentialdiagnostischen Schmerzausschaltung oder (selten) der Kontrastmittelapplikation für die Magnetresonanzarthrographie. Therapeutische Punktionen ermöglichen die Injektion von Medikamenten oder plättchenreichem Plasma (PRP) sowie die Entlastung bzw. Drainage von Ergüssen.

Kontraindikationen
Bei entzündlichen und insbesondere eitrigen Hautveränderungen im Punktionsbereich sind Gelenkpunktionen kontraindiziert.
Obwohl keine absolute Kontraindikation, ist bei Einnahme blutgerinnungswirksamer Substanzen Vorsicht geboten.

Operationstechnik
Besonderes Augenmerk ist auf ein steriles Vorgehen zu legen. Unnötige Schmerzen können durch das sterile Setzen einer Lokalanästhesiequaddel, „sichere“ Punktionspunkte sowie vorsichtiges Hantieren mit den Punktionskanülen vermieden werden.

Weiterbehandlung
Punktate müssen entsprechend den lokalen, intrahospitalen Richtlinien zeitgerecht aufgearbeitet bzw. entsorgt werden. Die Punktionsstellen werden mit sterilem Pflasterverband abgedeckt, bei Medikamentenapplikation die Gelenke zur Verteilung des Wirkstoffes passiv durchbewegt. Danach erfolgt eine Kompressionsbehandlung mit elastischer Bandage von distal nach proximal bis über die Punktionsstelle zur Vermeidung von Nachblutungen oder sofortiger Ergussneubildung.

Fakten
Werden sämtliche Maßnahmen der Sterilität bei der Punktion großer Gelenke eingehalten, ist davon auszugehen, dass Infektionen mit 0,04–0,08 % (4 bis 8/10.000 Punktionen) nur sehr selten auftreten. Das Risiko für falsch positive Erregernachweise ist äußerst gering.
Bayerisches Meldeportal für Corona-Reihenuntersuchungen – Entwicklung und Einsatz einer digitalen Lösung in der Pandemie
Authors: Flöter Jessica , Roll Julia , Kirchner Anna , Hung Chu-Wei , Riedl Anna , Kotula Katharina , Mühle-Schäffer Ursula , Tomandl Johanna , Ewert Thomas , Heinrich Ralf , Schlegel Christoph , Markl Christian , Nennstiel Uta , Liebl Bernhard , Weidner Christian , Wildner Manfred , Keil Thomas , Stupp Carolin 
Published: January 2023

ZusammenfassungZur Unterstützung der Entscheidungsträger werden in der SARS-CoV-2-Pandemie unterschiedlichste Daten erhoben, um ein möglichst genaues Lagebild zur Steuerung von Pandemiemaßnahmen zu erhalten. Nur wenig hilfreich sind dabei sowohl Papier und Stift als auch der Versand einzelner medienbruchbehafteter Dateien, die später zusammengefügt werden müssen. Es wird eine solide und zeitnah zur Verfügung stehende Datengrundlage benötigt. Das Bayerische Meldeportal für Corona-Reihenuntersuchungen (BayCoRei) stellt mit der gewählten Systemarchitektur eine zentrale bayernweit einheitliche digitale Lösung dar, die agil und einfach zu bedienen ist. BayCoRei greift auf bereits etablierte technische Komponenten und Schnittstellen zurück. Neben den technischen Komponenten spielt die Unterstützung der einzelnen Akteure (Gesundheitsämter, Leistungserbringer, Bezirksregierungen etc.) eine entscheidende Rolle für den Erfolg der Lösung. Dieser Beitrag zeigt am Beispiel von BayCoRei und 2 anderen Online-Meldeportalen, welche Technik und Architektur sich für einen (eiligen) Aufbau etabliert haben, aber ebenso, wo sich Wunsch und Wirklichkeit auch im Hinblick auf die Steuerung der Pandemiemaßnahmen unterscheiden.
Understanding the ablation rate of Holmium:YAG and thulium fiber lasers. Perspectives from an in vitro study
Authors: Basulto-Martínez Mario , Proietti Silvia , Pavia Maria Pia , Yeow Yuyi , Eisner Brian H. , Giusti Guido 
Published: January 2023

AbstractThis study sought to analyze the ablation rates of Holmium:YAG (Ho:YAG) and thulium fiber laser (TFL) under different settings combinations. Lasering was carried out by a computed spiral pattern through a stepper motor bearing a laser fiber. BegoStones were placed inside a water container and lasered therein and the ablation rate was calculated. Different combinations were tested for ~12 Watts (W) for Ho:YAG and TFL lasers. Further 25 W combination for TFL were conducted testing higher frequencies. One-hundred-one experiments were conducted. Under ~12 W, the highest ablation rate for Ho:YAG was obtained with 40 Hz/0.3 J, and Virtual Basket™ (VB) emission mode [114.35 (88.30 – 126.40) mg/min] whereas for TFL, using 40 Hz/0.3 J, and long pulse [143.40 (137.40 – 146) mg/min]. A matched-comparison for 12 Hz/1 J settings showed that TFL outperformed Ho:YAG using medium pulse [63.30 (55.30 – 81.30) vs 132.00 (115.70 – 228.60) mg/min, p=0.016] and long pulse [62.90 (51.60 – 78.90) vs 134.70 (110.60 – 149.30) mg/min, p=0.016]. In the 40 Hz/0.3 J settings, TFL outperformed Ho:YAG (p=0.034). Nonetheless, Ho:YAG with VB’s ablation rate increased [114.35 (88.30 – 126.40)], being comparable to that of TFL with medium pulse [127.5 (88.90 – 141.70)] (p=0.400). In TFL 25 W experiments, the ablation rate of 500 Hz / 0.05 J, was higher than those of 1000 Hz / 0.025 J (p=0.049). TFL ablation rate is higher than that of Ho:YAG. Moreover, the Virtual Basket™ emission mode, increased Ho:YAG ablation rates, resulting reaching similar to that of TFL in certain modalities.
“Therapy without a therapist?” The experiences of adolescents and their parents of online behavioural activation for depression with and without therapist support
Authors: Andersson Rebecca , Vigerland Sarah , Ahlen Johan , Widström Hanna , Unger Irma , Serlachius Eva , Engberg Hedvig 
Published: January 2023

AbstractBehavioural Activation (BA) is an established treatment for adults with depression, and research on BA for adolescents is promising. However, there is a knowledge gap in terms of the experiences of adolescents and their parents BA for depression delivered online. Furthermore, there have been no previous studies conducted on the experiences of respondents with regard to the role of the therapist in online treatment. Therefore, the primary aim of this study is to explore the experiences of online BA among adolescents with depression and how their parents experience supporting their adolescent through treatment. Second, the experiences of having online therapy with or without a therapist were explored. Semi-structured interviews were conducted with eight adolescents and nine parents (n = 17) who completed guided or self-guided online BA. Reflexive thematic analysis was used to identify aspects of the experience of treatment that were important to adolescents and their parents. Two main themes were generated: (1) opportunities or barriers to engaging in treatment and (2) parental involvement is valued and welcomed. This study contributes valuable information regarding user experiences of BA treatment, the importance of therapist support and parental involvement in treating adolescents with depression.Trial registration number:
ClinicalTrials.gov Identifier NCT04117789, Date of registration: 07 October 2019.
An experimental guide to in operando electrochemical Raman spectroscopy
Authors: Lenk Thorben , Schröder Uwe 
Published: January 2023

AbstractElectrochemical Raman spectroscopy can provide valuable insights into electrochemical reaction mechanisms. However, it also shows various pitfalls and challenges. This paper gives an overview of the necessary theoretical background, crucial practical considerations for successful measurement, and guidance for in situ/in operando electrochemical Raman spectroscopy. Several parameters must be optimized for suitable reaction and measurement conditions. From the experimental side, considerations for the setup, suitable signal enhancement methods, choice of material, laser, and objective lens are discussed. Different interface phenomena are reviewed in the context of data interpretation and evaluation.
Graphical Abstract
The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells
Authors: Nosrati Fariba , Grillari Johannes , Azarnia Mahnaz , Nabiuni Mohammad , Moghadasali Reza , Karimzadeh Latifeh , Lämmermann Ingo 
Published: January 2023

AbstractTissue fibrosis is associated with the aging process of most of our organs, and organ aging correlates with the chronic accumulation of senescent cells. Fibrosis occurs when fibroblasts proliferate and deposit pathological amounts of extracellular matrix (ECM), leading to progressive tissue scarring and organ dysfunction. Fibroblasts play a key role in fibrosis, especially in the skin where fibroblasts are the most abundant cell type in the dermis and are mainly responsible for the synthesis of ECM. This study aims to investigate how senescent fibroblasts and their secretome influence dermal fibrosis. Here we used human dermal fibroblasts (HDFs) treated with doxorubicin (doxo) to induce senescence. The senescent phenotype of these stress-induced premature senescent (SIPS) cells was confirmed with several markers. The expression of pro-fibrotic genes was quantified and finally, the impact of their secretome on the fibrotic response of non-senescent fibroblasts was assessed. Doxorubicin treatment, induced senescence in fibroblasts which has been confirmed with elevated senescence-associated β- galactosidase (SA-β-gal) activity, absence of BrdU incorporation, upregulation of p21, and loss of Lamin b1. Expression levels of the pro-fibrotic genes ACTA2 and FN1 increased in SIPS cells, but in contrast to studies using lung fibroblasts the secretome of these cells failed to induce a paracrine fibrotic response in non-senescent cells. In general, these results suggest that these senescent cells are potentially profibrotic, and their accumulation can trigger fibrosis in organs.
Beauty and the beast: multiple effects of wild boar rooting on butterfly microhabitat
Authors: Labadessa Rocco , Ancillotto Leonardo 
Published: January 2023

AbstractWild boar is among the most abundant ungulates in Europe and its spread is locally creating concerns as a major threat to biodiversity. However, through their rooting activity, wild boars could play an effective role in the creation of specific microhabitat resources for plants and animals. Here, we tested the hypothesis that wild boar affects the habitat suitability to threatened butterflies, by evaluating the influence of rooting on multiple key aspects of the biology and ecology of the Mediterranean endemicZerynthia cassandra. Namely, we usedZ. cassandraas a model to test the effects of wild boar rooting on adult foraging opportunities, host plant occurrence, and oviposition site selection. We found that herbaceous communities disturbed by wild boar rooting have a higher proportion of plants representing nectar resources for early-flying butterflies. We also discovered that wild boar rooting positively influences the occurrence and abundance of the larval host plant ofZ. cassandra, as well as the butterfly site selection for egg-laying. Our results indicate that wild boars may locally prove beneficial to endangered butterflies by favoring habitat quality and availability, and their role as ecosystem engineers should thus be further investigated to improve species and habitat management and conservation actions.
Isocitrate-dehydrogenase-mutant lower grade glioma in elderly patients: treatment and outcome in a molecularly characterized contemporary cohort
Authors: Dao Trong P. , Gluszak M. , Reuss D. , von Deimling A. , Wick A. , König L. , Debus J. , Herold-Mende C. , Unterberg A. , Jungk C. 
Published: January 2023

Abstract
Purpose
Lower-grade glioma (LGG) is rare among patients above the age of 60 (“elderly”). Previous studies reported poor outcome, likely due to the inclusion of isocitrate dehydrogenase (IDH) wildtype astrocytomas and advocated defensive surgical and adjuvant treatment. This study set out to question this paradigm analyzing a contemporary cohort of patients with IDH mutant astrocytoma and oligodendroglioma WHO grade 2 and 3.

Methods
Elderly patients treated in our department for a supratentorial, hemispheric LGG between 2009 and 2019 were retrospectively analyzed for patient-, tumor- and treatment-related factors and progression-free survival (PFS) and compared to patients aged under 60. Inclusion required the availability of subtype-defining molecular data and pre- and post-operative tumor volumes.

Results
207 patients were included, among those 21 elderlies (10%). PFS was comparable between elderly and younger patients (46 vs. 54 months; p = 0.634). Oligodendroglioma was more common in the elderly (76% vs. 46%; p = 0.011). Most patients underwent tumor resection (elderly: 81% vs. younger: 91%; p = 0.246) yielding comparable residual tumor volumes (elderly: 7.8 cm3; younger: 4.1 cm3; p = 0.137). Adjuvant treatment was administered in 76% of elderly and 61% of younger patients (p = 0.163). Uni- and multi-variate survival analyses identified a tumor crossing the midline, surgical strategy, and pre- and post-operative tumor volumes as prognostic factors.

Conclusion
Elderly patients constitute a small fraction of molecularly characterized LGGs. In contrast to previous reports, favorable surgical and survival outcomes were achieved in our series comparable to those of younger patients. Thus, intensified treatment including maximal safe resection should be advocated in elderly patients whenever feasible.