bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydatid cyst of papillary muscle concomitant with brain involvement
Authors: Taherkhani Maryam , Yeganegi Houra , Bagheri Amin 
Published: January 2023

AbstractBackgroundCardiac hydatidosis is a rare disease and the subepicardial region of the left ventricular is commonly affected. However, papillary muscle concomitant with brain involvement has not been previously reported.CaseWe report a 44 years old man who complained of headache along with no cardiac symptoms. The patient was diagnosed with cerebral hydatid cyst. Through preoperative cardiac consultant, transthoracic echocardiography revealed cardiac hydatid cyst confined to the anterolateral papillary muscle. Medical treatment was started promptly and successful surgical excision of all cysts was performed. The patient had an uneventful recovery and follow up at 3 months.ConclusionEarly diagnosis of cardiac HC by echocardiography is recommended in all patients with hydatid disease, regardless of HC location.
Detection of clinical high risk for psychosis in child and adolescent mental health services: Validation of the first step with the French versions of the Prodromal Questionnaire (fPQ‐16) and scale of Perceptual and Cognitive Aberrations (fPCA)
Authors: Spillebout Chloé , Pelluet Albane , Bioulac Stéphanie , Fourneret Pierre , Polosan Mircea , Dondé Clément 
Published: January 2023

AbstractAimTo validate the French versions of the 16‐items Prodromal Questionnaire (PQ‐16) and the 9‐items scale of Perceptual and Cognitive Aberrations (PCA) to facilitate screening of psychosis risk in native French‐speaking young individuals referred to Child and Adolescent Mental Health Services.MethodParticipants (N = 87, age range 10—18 years) were diagnosed with a non‐psychotic disorder according to the Diagnostic and Statistical Manual of Mental Disorders. The French versions of the PQ‐16 and PCA were developed using a forward–backward translation procedure. Psychometric properties were tested including (i) internal validity with Pearson correlations and Cronbach's coefficients, and (ii) external validity by correlations with each other's.Results(i) Correlations between fPQ‐16 and fPCA total scores and individual items were mostly >.4. Cronbach's coefficients were .80 for the fPQ‐16 and .61 for the fPCA. (ii) The fPQ‐16 and fPCA total scores were significantly correlated with a large effect size (rs = 0.66).ConclusionThe fPQ‐16 and the fPCA are psychometrically acceptable instruments for the screening of potential psychotic symptoms in French‐speaking children and young adolescents under 18 years old referred to Child and Adolescent Mental Health Services.
‘Like I said about culture. You don't talk about mental health’: An interpretative phenomenological analysis of the experience of first‐episode psychosis in South Asian individuals
Authors: Patel Krisna , Cardno Alastair , Isherwood Tom 
Published: January 2023

AbstractBackgroundThere is strong evidence of inequalities in mental healthcare access, experiences and outcomes for service users belonging to Black and Asian Minority Ethnic groups experiencing psychosis. Clinicians and academics have speculated that cultural variation in conceptualisations of psychosis, alongside inequitable service provision may explain disparities. There is, however, a dearth of literature exploring this in a South Asian population, despite this ethnic group being the second largest in the United Kingdom. The present study aimed to explore how people from this minority group have experienced and made sense of first‐episode psychosis (FEP).MethodsA qualitative approach was used to explore the lived experience and sense‐making of South Asian individuals experiencing FEP and accessing early intervention services. Eight people were interviewed using a semi‐structured format. The data were analysed using Interpretative Phenomenological Analysis.ResultsThree superordinate themes were identified in the group analysis: (1) Disconnection from self and others (2) Doubt and dispute (3) Power and shame.ConclusionsDistinctive ethnic, cultural and systemic influences were strongly evident in how people conceptualized their experiences, how they managed their sense‐making and where they sought support. Experiences were discussed in the context of power and shame, and this research proposes that socio‐cultural context and racialised discourses have an impact on self‐concept, the experiences of help‐seeking (formal and informal), and fundamentally how services help individuals from marginalized communities.
Exploring digital cognitive behavioural therapy for insomnia in an early intervention in psychosis service – A study protocol for an initial feasibility study with process evaluation
Authors: Beattie Louise , Robb Fiona , Spanswick Mairi , Henry Alasdair L. , Waxmonsky Jeanette , Gumley Andrew 
Published: January 2023

AbstractAimEarly psychosis may be a critical time at which clinical trajectories are still evolving, and sleep interventions hold promise to improve outcomes at this stage. Although cognitive behavioural therapy (CBT) for insomnia shows promise in psychosis, there has been limited evaluation of delivery within current care. This study aims to evaluate the feasibility and acceptability of providing fully‐automated digital CBT for insomnia (CBT‐I) within an early intervention in psychosis service.MethodsWe will conduct a single‐arm feasibility trial within an early psychosis intervention service, and up to 40 individuals experiencing a first episode of psychosis and with evidence of insomnia can be enrolled (May 2021 – August 2022). Additional service user inclusion criteria are capacity to consent and access to a suitable technological device to access digital CBT. Participants will be offered access to a fully‐automated digital CBT‐I program (Sleepio) delivered using web and/or mobile app. The study comprises pre‐ and post‐ intervention questionnaire assessments and interviews with service users and staff to provide initial outcome signals.ResultsQuantitative questionnaire data will be analysed descriptively, alongside rates of eligibility, consent, uptake and completion. Qualitative data will be analysed using thematic analysis. Results will be used to develop a logic model describing feasibility and implementation.ConclusionsFrom this study, we hope to better understand how to deliver digital CBT for insomnia within an early intervention in psychosis service. This study will help inform further research, including how best to support staff in using Sleepio, and inform the design of subsequent trials in this area.
The ‘Parma At‐Risk mental states’ (PARMS) program: General description and process analysis after 5 years of clinical activity
Authors: Pelizza Lorenzo , Leuci Emanuela , Quattrone Emanuela , Paulillo Giuseppina , Pellegrini Pietro 
Published: January 2023

AbstractAimFrom January 2016, the Parma Department of Mental Health developed a specialized care protocol – the ‘Parma At‐Risk Mental States’ (PARMS) program – as a diffused service for early intervention in individuals at Clinical High Risk for Psychosis (CHR‐P). The aims of this investigation were (1) to describe the PARMS structural organization and (2) to examine specific process indicators during the first 5 years of its clinical activity.MethodsAll participants were adolescent and young adult help‐seekers (aged 12–25 years) at CHR‐P in accordance with well‐defined psychometric criteria.ResultsAt entry, 52 subjects were provided with a dedicated protocol of care and only 14 dropped out during the first year of treatment. The Duration of Untreated Illness (DUI) overall decreased over time. Most of CHR‐P participants suffered from ‘Attenuated Psychotic Symptoms’ and ‘Brief, Limited, Intermittent Psychotic Symptoms’ in the same percentage (48.1% [n = 25]). The most common DSM‐IV‐TR diagnosis was schizotypal personality disorder, followed by borderline personality disorder and brief psychotic disorder.ConclusionsA specialized, evidence‐based care protocol for CHR‐P individuals within Italian adult and child/adolescent psychiatric services is feasible, also in adolescents, who have a high risk of falling through the child/adult service gap.
Pharmacokinetic and pharmacodynamic study of three products of epoetin alfa as single subcutaneous dose in healthy volunteers
Authors: di Girolamo Guillermo , Keller Guillermo A. , Beider Lara , González Claudio D. , González Bagnes María F. , González Eliseo , Fornari M. Cecilia , Diez Roberto A. 
Published: January 2023

AbstractHemax® is an epoetin alfa product developed by Biosidus S.A. in Argentina at the end of the 1980s and has been present in that market since 1991. The initial presentation was a lyophilized powder containing albumin as stabilizer, to best adapt to environmental conditions in developing countries; more recently, a prefilled syringe, albumin‐free presentation was developed, since this presentation has become the preferred standard in many markets. The primary objective was to compare the pharmacokinetic profile of different formulations of epoetin alfa after a single subcutaneous administration to healthy volunteers of 40 000 IU of Eprex/Erypo® and Hemax® PFS. This clinical trial was conceived following an open‐label, randomized, three‐way three‐period cross‐over balanced, and sequential design. The study was conducted on 24 healthy volunteers. To analyze similarity between Hemax® PFS and the innovator product, Eprex®, area under the curve (AUC) and Cmax of both products have been compared. The 90% CI lower limit for the geometric mean ratios was higher than 80% for any comparisons, and the 90% CI upper limit for these geometric ratios was below 125% for all the comparisons made, thus demonstrating equivalence between both products. The comparison between Hemax® PFS and Eprex® resulted in similar 90% CI for Cmax, AUC(0–120 h) and AUC(0‐inf) ratios, all of them within the 80–125% interval, with a power above 95% for each ratio. These findings suggest biosimilar patterns for absorption velocity (with Tmax close to 15 h), absorption extent, and elimination (with an elimination half‐life close to 25–30 h for each formulation).
Comparative analysis of first and second stage data envelopment approaches: Performance of marine capture fisheries in the European Union
Authors: Tunca Sezgin 
Published: January 2023

AbstractI explored harvest productivity and economic efficiency of marine fisheries across European Union member states using comparative first and second‐stage data envelopment analyses, linear programming, and econometric models, based on a panel data set of technical, social, and economic data between 2008 and 2020 when the first implications of the global Covid‐19 outbreak began in the European Union. During the period, harvest productivity increased for 52 percent of the 21 member states between 2008 and 2020, with an average economic efficiency of 0.76. The economic efficiency and harvest productivity of European Union member states' fisheries fluctuated, with noticeable declines throughout the study period. Gross domestic product per capita, population size, and aquaculture production were related to performance metrics. The results are aimed to guide European Union fisheries managers to better understand how improvements in harvest productivity and economically efficient performance are achieved without constant reliance on subsidization, over‐allocation, and overexploitation.
Effect of the Lactiplantibacillus plantarum and Lentilactobacillus buchneri on corn and sorghum silage quality and sheep energy partition under tropical conditions
Authors: de Assis Pires Frederico Patrus Ananias , Tomich Thierry Ribeiro , Pereira Luiz Gustavo Ribeiro , Machado Fernanda Samarini , Campos Mariana Magalhães , de Oliveira Alan Figueiredo , Menezes Guilherme Lobato , de Menezes Rafael Araújo , de Sousa Pamella Grossi , Jayme Diogo Gonzaga , Gonçalves Lúcio Carlos 
Published: January 2023

AbstractThis study aimed to evaluate the silage quality, ingestive behaviour, and sheep energy partition fed corn and sorghum silages, with or without inoculation with Lactiplantibacillus plantarum and Lentilactobacillus buchneri. Whole plants of one dent corn hybrid (DCS), one flint corn hybrid (FCS), and one forage sorghum hybrid (SS) were ensiled with or without an inoculant containing L. plantarum and L. buchneri (4 × 105 CFU g−1), totalling six treatments (3 × 2 factorial scheme). The treatments were ensiled in metal drums with 200 L capacity. The lactic acid concentrations in the inoculated FCS and DCS were higher by 13.4% and 12.8%, respectively, than those in the non‐inoculated plants. In contrast, the lactic acid concentration in the inoculated SS was 23.1% lower than that in the non‐inoculated SS. Furthermore, there were differences in pH and acetic acid concentrations only in SS, which were 2.3% and 45.2% higher, respectively, in inoculated silage than in non‐inoculated silage. In inoculated DCS and SS, propionic acid concentrations were 1.7 times higher (for both silages), and 1‐propanol was 3.7 and 1.8 times higher compared than those in non‐inoculated silages. There was a main effect of the inoculant on 1,2‐propanediol concentrations, which were 37.5% higher in inoculated silages than in non‐inoculated silages. However, ingestive behaviour, heat and methane production, and silage net energy concentrations were not affected by inoculant use. Fermentative modifications caused by inoculation with L. plantarum and L. buchneri in whole plant corn or sorghum silage did not modify sheep energy partition.
Performance of an implantable cardioverter‐defibrillator lead family
Authors: Klampfleitner Stefanie , Mundel Markus , Schinke Karin , Neuberger Hans‐Ruprecht 
Published: January 2023

AbstractBackgroundLead failure is the major limitation in implantable cardioverter‐defibrillator (ICD) therapy. Long‐term follow‐up data for Biotronik Linox ICD leads are limited. Therefore, we analyzed the performance of all these leads implanted at our institution.Materials and MethodsAll Linox and Linox Smart ICD leads implanted between 2006 and 2015 were identified. Lead failure was defined as electrical dysfunction (oversensing, abnormal impedance, exit block). Lead survival was described, according to Kaplan–Meier. Associations between lead failure and specific variables were examined. p < .05 was considered significant.ResultsWe included 417 ICD leads. The median follow‐up time for Linox (n = 205) was 81 months and for Linox Smart (n = 212) 75 months. During that follow‐up time, 30 Linox (14.6%) and 16 Linox Smart leads (7.6%) showed a malfunction. The 5‐year lead survival probability was 97.4% for Linox and 95.2% for Linox Smart (log‐rank test, p = .19). The 6‐ and 8‐year lead survival probability for Linox was 93.6% and 84.6%, and for Linox Smart 93% and 91.9%. The only factor significantly associated with lead failure was younger patient age at implantation (hazard ratio/year: 0.97, 95% CI: 0.94–0.99, p = .002).ConclusionThis relatively large study with a long follow‐up period highlights a relevant failure rate of Biotronik Linox leads. The performance of Linox versus Linox Smart ICD leads was comparable. Although we show an acceptable 5‐year lead survival probability, we observed a marked drop after just 1 more year of follow‐up. In an era of improving heart failure survival probability, a prolonged follow‐up of ICD leads is increasingly clinically relevant.
Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long‐term outcomes in patients with and without structural heart disease
Authors: Sessions Andrew J. , May Heidi T. , Crandall Brian G. , Day John D. , Cutler Michael J. , Groh Christopher A. , Navaravong Leenapong , Ranjan Ravi , Steinberg Benjamin A. , J. Bunch Thomas 
Published: January 2023

AbstractIntroductionAtrial Fibrillation (AF) is a common arrhythmia often comorbid with systolic or diastolic heart failure (HF). Catheter ablation is a more effective treatment for AF with concurrent left ventricular dysfunction, however, the optimal timing of use in these patients is unknown.MethodsAll patients that received a catheter ablation for AF(n = 9979) with 1 year of follow‐up within the Intermountain Healthcare system were included. Patients with were identified by the presence of structural disease by ejection fraction (EF): EF ≤ 35% (n = 1024) and EF > 35% (n = 8955). Recursive partitioning categories were used to separate patients into clinically meaningful strata based upon time from initial AF diagnosis until ablation: 30–180(n = 2689), 2:181–545(n = 1747), 3:546–1825(n = 2941), and 4:>1825(n = 2602) days.ResultsThe mean days from AF diagnosis to first ablation was 3.5 ± 3.8 years (EF > 35%: 3.5 ± 3.8 years, EF ≤ 35%: 3.4 ± 3.8 years, p = .66). In the EF > 35% group, delays in treatment (181–545 vs. 30–180, 546–1825 vs. 30–180, >1825 vs. 30–180 days) increased the risk of death with a hazard ratio (HR) of 2.02(p < .0001), 2.62(p < .0001), and 4.39(p < .0001) respectively with significant risks for HF hospitalization (HR:1.44–3.69), stroke (HR:1.11–2.14), and AF recurrence (HR:1.42–1.81). In patients with an EF ≤ 35%, treatment delays also significantly increased risk of death (HR 2.07–3.77) with similar trends in HF hospitalization (HR:1.63–1.09) and AF recurrence (HR:0.79–1.24).ConclusionDelays in catheter ablation for AF resulted in increased all‐cause mortality in all patients with differential impact observed on HF hospitalization, stroke, and AF recurrence risks by baseline EF. These data favor earlier use of ablation for AF in patients with and without structural heart disease.
Ripple mapping in ventricular tachycardia substrate mapping and ablation of nonischemic ventricular tachycardia
Authors: Gilge Jasen L. , Joshi Sandeep A. , Nair Girish V. , Clark Bradley A. , Prystowsky Eric N. , Patel Parin J. 
Published: January 2023

AbstractIntroductionSubstrate‐based ablation for ventricular tachycardia (VT) using Ripple map (RM) is an effective treatment strategy for patients with ischemic cardiomyopathy but has yet to be evaluated in patients with nonischemic cardiomyopathy (NICMO). The aim of this study is to determine the feasibility and effectiveness of an RM‐based ablation for NICMO patients.Methods and ResultsThis was a single‐center, retrospective study including all NICMO patients undergoing VT ablation at St Vincent Hospital between January 1, 2018 and January 12, 2019. Retrospective RM analysis was performed on those that had a substrate‐based ablation to identify the location and number of Ripple channels as well as their proximity to ablation lesions. Thirty‐three patients met the inclusion criteria and had a median age of 65 (58, 73.5) with 15.2% of the population being female, and were followed for a median duration of 451 (217.5, 586.5) days. Of these patients, 23 (69.7%) had a substrate‐based ablation with a median procedural duration of 196.4 (186.8, 339) min, 1946 (517, 2750) points collected per map, and 277 (141, 554) points were within the scar. Two (8.6%) procedural complications occurred, and 7 (30.4%) patients had VT recurrence during follow‐up. RM analysis revealed an average of two Ripple channels and the patients without VT recurrence had ablation performed closer to the Ripple channels: 0 (0, 4.7) versus 14.3 (0, 23.5) cm; p = .02.ConclusionAn RM‐based substrate ablation can be performed in NICMO patients and ablation within Ripple channels is a predictor of VT freedom.
Assisted reality device to guide cardiac implantable device programming in distant rural areas
Authors: Diaz Juan C. , Cañas Felipe , Duque Mauricio , Aristizabal Julian , Niño Cesar , Bastidas Oriana , Marin Jorge , Rivera Estefania , Hoyos Carolina , Matos Carlos , Peralta Adelqui , Martin David T. , Romero Jorge 
Published: January 2023

AbstractBackgroundPatients with cardiac implantable electronic devices (CIEDs) living in rural areas have difficulty obtaining follow‐up visits for device interrogation and programming in specialized healthcare facilities.ObjectiveTo describe the use of an assisted reality device designed to provide front‐line workers with real‐time online support from a remotely located specialist (Realwear HTM‐1; Realwear) during CIED assistance in distant rural areas.MethodsThis is a prospective study of patients requiring CIED interrogation using the Realwear HMT‐1 in a remote rural population in Colombia between April 2021 and June 2022. CIED interrogation and device programming were performed by a general practitioner and guided by a cardiac electrophysiologist. Non‐CIED‐related medical interventions were allowed and analyzed. The primary objective was to determine the incidence of clinically significant CIED alerts. Secondary objectives were the changes medical interventions used to treat the events found in the device interrogations regarding non‐CIED related conditions.ResultsA total of 205 CIED interrogations were performed on 139 patients (age 69 ± 14 years; 54% female). Clinically significant CIED alerts were reported in 42% of CIED interrogations, consisting of the detection of significant arrhythmias (35%), lead malfunction (3%), and device in elective replacement interval (3.9%). Oral anticoagulation was initiated in 8% of patients and general medical/cardiac interventions unrelated to the CIED were performed in 52% of CIED encounters.ConclusionRemote assistance using a commercially available assisted reality device has the potential to provide specialized healthcare to patients in difficult‐to‐reach areas, overcoming current difficulties associated with RM, including the inability to change device programming. Additionally, these interactions provided care beyond CIED‐related interventions, thus delivering significant social and clinical impact to remote rural populations.