bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and patient-centered outcomes following rehabilitation of atrophic edentulous maxilla using six implants placed simultaneously with bilateral maxillary sinus augmentation: a retrospective case series
Authors: Sharaf Mufeed Ahmed , Jiang Jimin , Wang Siyuan , Xiao Pei , Xu Antian , He Fuming 
Published: December 2022

Abstract
Objectives
To evaluate treatment success, patient satisfaction, and oral health-related quality of life (OHRQoL) after rehabilitation of atrophic edentulous maxilla (AEM) with six implants placed simultaneously with bilateral maxillary sinus floor augmentation (MSFA).
Materials and methods
The selected patients were fully edentulous with atrophic maxillary posterior residual ridges, who rehabilitated with 6 implants placed simultaneously with bilateral MSFA and immediate all-on-4 provisional fixed prosthesis (PFP). After 7–12 months of implant surgery, all patients have received all-on-6 definitive fixed prosthesis (DFP). After at least one year of function with DFP, the clinical and radiographic examinations were performed. Patient satisfaction with DFP was assessed through a visual analog scale (VAS). The OHRQoL before treatment (T0), during provisional (T1), and after definitive prosthesis (T2) was evaluated using OHI-14.
Results
20 maxillary edentulous patients were rehabilitated with 120 implants (6 for each maxilla combined with bilateral MSFA), 20 immediate all-on-4 PFP, and 20 all-on-6 DFP. Of those,12 patients have passed at least year follow-up after DFP insertion, and were eligible to be included for the assessment of treatment success. After a mean of 20 (12–36) months follow-up, the implant and prosthesis survival rate were both 100%. The success rate at the implant level was 98.6%. The peri-implant soft tissue condition was stable without biological complications. The mean marginal bone loss (MBL) was 0.09 ± 0.06 mm. No prosthetic or postoperative complications was observed. The patient satisfaction after treatment was high and the mean general satisfaction was (91.75 ± 7.06). There was a significant improvement in most OHIP-14 domains during the provisional all-on-4 (T1) and in all domains during the final all-on-6 prosthesis (T2) (P < 0.01).
Conclusions
Rehabilitation of the AEM utilizing six implants combined with simultaneous bilateral MSFA, immediate All-on-4 PFP, and delayed All-on-6 DFP is a successful treatment approach associated with minimal postoperative complications high patient satisfaction, significant improvement in OHRQoL.
Clinical relevance:
Rehabilitation of AEM with six implants inserted simultaneously with bilateral MSFA enables the prosthesis to restore/extend to the first or second molars without a cantilever, which improves clinical outcome and OHRQoL compared to cantilevered and shortened dental arch concept prosthesis.
Neuroprotective Effects of Sinapic acid and Ursolic acid in Vanadium-Induced Neurotoxic effect in Rat.
Authors: Jaiswal Madhuri , Gupta Varun , Pallar Anita , Siddique Aqsa , Kale Pravin 
Published: December 2022

Abstract
The antioxidant and anti-inflammatory agent may be an effective combination against neuroinflammation and oxidative stress in neurotoxicity. Sinapic acid acts as a potential antioxidant and ursolic acid acts as an anti-inflammatory agent. In this study, we investigate the neuroprotective effect of SA and UA against vanadium-induced neurotoxicity. 56 male Wistar rats were equally divided into eight groups and received Sodium metavanadate along with Sinapic Acid and Ursolic Acid. Various behavioural and biochemical parameters were evaluated and histology for the same was performed. Administration of SMV led to a decline in behavioural patterns and resulted in impaired memory assessed by the behavioural study. Treatment with SA and UA as monotherapy and combination dose, increased activity of antioxidant enzymes and anti-inflammatory activity was observed with decreased expression of TNF-α and IL-1β.The current study indicates a possible additive effect of Sinapic Acid + Ursolic Acid in combination dose, exerting a protective effect by improving cognitive decline, locomotor activity, and improving oxidative stress in vanadium-induced neurotoxicity.
Drug Use and its correlated factors among University students in Tehran
Authors: Delavari Sahar , Olamazadeh Sogol , Baheshmat Shahab , Gholami Jaleh , Shadloo Behrang , Amin-Esmaeili Masoumeh , Rahimi-Movaghar Afarin 
Published: December 2022

Abstract
Objective: This study aimed to investigate the prevalence of lifetime, last year, and last month use of illicit drugs (opioids, cannabis, stimulants, and hallucinogens) and associated factors among the first to fourth-year students at the Tehran University of Medical Sciences in Iran.
Method: The sampling method was multi-stage cluster sampling. Anonymous, self-administered questionnaires used in the previous similar surveys were distributed to 1050 students. We provided prevalence of lifetime, last 12 months, last month, and daily use for the main classes of drugs. We evaluated correlated factors of any drug use in the past 12 months using the bivariate and multivariate logistic regression model.
Results: Overall, 945 students participated in this study. A total of 6.6% reported any illicit drug use in the past 12 months (11.2% among male students vs. 3.1% among female students, P > 0.05). Cannabis was the most used drug in the past year by both male and female students, reported by 4.9% of the participants, followed by methylphenidate (2.9%). Daily use of any illicit drug was reported only by 0.7% of male students and no female students. There was an association between illicit drug use in the past 12 months with smoking cigarettes and using alcohol in the past 12 months and drug use among friends or family members.
Conclusions: In general, the prevalence of drug use among the students at Tehran University of Medical Sciences has increased compared to similar previous studies, which call for preventive measures.
Genomic profiles of IDH-mutant gliomas: MYCN amplified IDH-mutant astrocytoma had the worst prognosis and true mixed oligoastrocytoma does not exist
Authors: Lee Kwanghoon , Kim Seong-Ik , Kim Eric Eunshik , Shim Yu-Mi , Won Jae-Kyung , Park Chul-Kee , Choi Seung Hong , Yun Hongseok , Lee Hyunju , Park Sung-Hye 
Published: December 2022

Abstract
Background
This study aims to find any ambiguous genetic outlier for “oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDH_mut)” and “astrocytoma, IDH-mutant (A_IDH_mut)” and to redefine the genetic landscape of IDH-mutant gliomas. Methods: The next-generation sequencing (NGS) using a brain tumor-targeted gene panel, methylation profiles, and clinicopathological features were analyzed in O_IDH_mut (n = 74) in 70 patients and A_IDH_mut (n = 95) in 90 patients.
Results
Three had ambiguous genetic profiles for either O_IDH_mut or A_IDH_mut. Two were unusual TP53-mutant O_IDH_mut, validated with the DKFZ methylation classifier (MC) (score: 0.98). The remaining one was a 1p/19q-codeleted and TERTp-mutant A_IDH_mut, which also had TP53 and CIC mutations. This case was matched to O_IDH_mut (Score: 0.75) by the DKFZ-MC v.11b4 algorithm but was corrected to A_IDH_mut_HG (high-grade) (Score: 0.84) using the updated DKFZ-MC v.12.5. The remaining 97.3% and 98.9% of O_IDH_mut and A_IDH_mut had a classic genomic landscape. The patients with MYCN amplified and/or CDKN2A/2B homozygously deleted A_IDH_mut had a worse prognosis than those without these genes’ alterations. Conclusion: CIC and/or FUBP1 mutations were detected in 93.2%, and MGMTp methylation was detected in 95.9% of O_IDH_mut patients. Accepting that 1p/19q codeletion and TP53 mutations are not 100% mutually exclusive, as are the three exceptional cases mentioned above, would be of great help in diagnosing the two subtypes of IDH-mutant diffuse glioma. In histopathologically or genetically ambiguous cases, MC can be an objective tool to avoid a diagnosis of NOS (not otherwise specified) or NEC (not elsewhere classified), as well as tumor classification. The authors have not encountered a true mixed oligoastrocytoma using an integrated diagnosis of genetic and methylation profiles. MYCN amplification, like CDKN2A/2B homozygous deletion, should be included in the genetic criteria for grade 4 A_IDH_mut.
Humic substances and oxidable fractions of organic matter in different environments in Amazônia Maranhense
Authors: Rego Carlos Augusto Rocha de Moraes , de Oliveira Paulo Sérgio Rabello , Muniz Luciano Cavalcante , Rosset Jean Sérgio , Mattei Eloisa , Costa Bruna Penha , Pereira Marcos Gervasio 
Published: December 2022

Abstract

The realization of soil management, without considering the limitations and potential of space, has contributed to the degradation of these environments, in different degrees, depending on the impact promoted on the soil attributes. This work investigated the levels of carbon (C), chemical, and oxidizable fractions of soil organic matter, in pasture areas with different recovery times, compared to a secondary forest. We evaluated the following forms of management: Secondary Forest (SF), Perennial pasture (PP), Perennial pasture recovered five years ago by the corn consortium + Brachiaria brizantha cv. Marandu (P5) and Perennial pasture recovered eight years ago by intercropping corn + Brachiaria brizantha cv. Marandu (P8). We determined the C contents of the oxidizable fractions (F1, F2, F3, and F4) and the contents and stocks of humic substances of organic matter in the layers of 0.00-0.10, 0.10-0.20, 0.20-0.30, and 0.30-0.40 m. We observed the highest levels of C in humic substances in areas SF, P8, and P5. Regarding the oxidizable fractions, we found in the P8 area the highest levels of C within the F1 and F3 fractions. Through the multivariate analysis employed, it was possible to evidence the following increasing order P8 > SF > P5 > PP of the impact on soil quality. The recovery of the pasture area, eight years ago, provided improvements regarding the accumulation of carbon in the soil in the oxidizable fractions and humic substances.
Intuitionistic Fuzzy Graph Mathematical Morphology and Some of its Properties
Authors: Jacob Abraham , B. Ramkumar P. 
Published: December 2022

Abstract
This paper studies the mathematical morphology operators acting on a lattice of all intuitionistic fuzzy sub graphs of an intuitionistic fuzzy graph (IFG). pn-adjacency of vertices and edges are defined as neighbourhoods of vertices and edges. We define vertex dilation, vertex erosion, edge dilation, edge erosion and some of their properties on intuionistic fuzzy graph using pn-adjacency of vertices and edges. We propose elementary mathematical morphology operators, dilation and erosion, on intuionistic fuzzy graph using pn-adjacency of vertices and edges based on lattice theory and also prove following basic properties of the proposed intuitionistic fuzzy graph mathematical morphology operators, dilation and erosion. (1) Dilation and erosion on IFG are increasing (2) Dilation is extensive. (3) Erosion is anti-extensive. (4) Dilation is distributive with respect to union and Erosion on IFG is distributive with respect to intersection. These properties are analogous to the properties of dilation and erosion in the classical Mathematical Morphology. So this paper is a theoretical extension of mathematical morphology on graphs to mathematical morphology on intuitionistic fuzzy graph.
MSC Classification: 68U10 , 05C72
Optimization of surveillance effectiveness for smart attendance based all-cause absenteeism : a longitudinal study, China, September 2021 to June 2022
Authors: Wang Weiye , Huang Xiaoliu , Yang Zhen 
Published: December 2022

Abstract
Background
Although smart attendance can only collect all-cause-absenteeism, which is conductive to the modernization of syndromic surveillance system (SSS). It is of great significance to optimize all-cause-absenteeism. The aim of this study was to choose appropriate standard for absenteeism and effective indicators for the face-recognition-based SSS (FRSSS).
Methods
Two primary schools in Hangzhou, China participated in this study. Grades 1-2 (DARL), 3-6 (DARH), and school-wide (DARX) all-cause-absenteeism reported by FRSSS, and all-cause (DARY) and sickness absenteeism (DARZ) reported by school physicians, were daily collected from September, 2021, to June, 2022, and their surveillance effectiveness were compared by by correlations, time series, and control charts.
Results
The time standard of absenteeism was "≥ 24 hours" for DARY and DARZ, while "≥ one hour" for DARX, DARL and DARH. DARY and DARZ were 32.6% and 25.2% of DARX. The correlation between DARY and DARZ was 0.843 (P<0.001) in school A and 0.933 (P<0.001) in school B. Yoden indexes of DARL, DARH, DARX, DARY and DARZ were 83.0%, 85.0%, 80.6%, 78.2% and 80.4% in school A, and 89.3%, 91.0%, 83.9%, 76.8% and 81.0% in school B, respectively.
Conclusions
The surveillance effectiveness of all-cause-absenteeism could be raised to considerable level by setting reasonable standard and adopting multi-level indicators. It is feasible and effective to popularize smart attendance in school-oriented SSSs.
Ice-Inspired Polymeric Slippery Surface with Excellent Smoothness, Stability and Antifouling Properties
Authors: Tan Runxiang , Hao Peng , Wu Daheng , Yang Haoyong , Xia Yifu , Li Shengfei , Wang Jianing , Liang Lisha , Zhou Jin , Zhang Tao 
Published: December 2022

Abstract
The ice is omnipresent in our daily life and possesses intrinsic slipperiness due to the formation of a quasi-liquid layer. Thus, the functional surfaces inspired by the ice show great prospects in widespread fields from surface lubrication to antifouling coatings. Herein, we report an ice-inspired polymeric slippery surface (II-PSS) constructed by a self-lubricating liquid layer and a densely surface-grafted polymer matrix. The smooth polymer matrix could capture lubricant molecules via strong and dynamic dipole-dipole interactions to form a stable quasi-liquid layer that resembles the ice surface. The resultant II-PSS can be easily fabricated on various solid substrates (e.g., silicon, glass, aluminium oxide, plastics, etc.) with excellent smoothness (roughness ~ 0.4 nm), optical transmittance (~ 94.5%), as well as repellency towards diverse liquids with different surface tensions (22.3 ~ 72.8 mN m-1), pH values (1-14), salinity and organic pollutants. Further investigation shows that the II-PSS exhibits extremely low attachment for proteins and marine organisms (e.g., algae and mussel) for over one month. These results demonstrate a robust and promising strategy for high-performance antifouling coatings.
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis
Authors: Li Xiaoming , Wo beibei , du chunyang , yang yan , qi huimin , liang zihui , he conghui , yao fang 
Published: December 2022

Abstract
Background: Allergic rhinitis (AR) is globally prevalent and its pathogenesis remains unclear. Alternative activation of macrophages is suggested in AR and thought to be involved in natural immunoregulatory processes in AR. Aberrant activation of Nod-like receptor protein 3 (NLRP3) inflammasome is linked with AR. Human placenta extract (HPE) is widely used in clinics due to its multiple therapeutic potential carried by diverse bioactive molecules. We aim to investigate the effect of HPE on AR and the possible underlying mechanism.
Methods: Ovalbumin (OVA)-induced AR rat model was set up and treated by HPE or cetirizine. General manifestation of AR was evaluated along with the histological and biochemical analysis performed on rat nasal mucosa. A proteomic analysis was performed on AR rat mucosa. Mouse alveolar macrophages (MH-S cells) were cultured under OVA stimulation to investigate the regulation of macrophages polarization. The morphological changes of nasal mucosa, the expression of NLRP3 inflammasome and immunity-related GTPase M (IRGM) in nasal mucosa as well as in MH-S cells were evaluated respectively.
Results: The general manifestation of AR along with the histological changes in nasal mucosa of AR rats were improved by HPE. HPE treatment suppressed NLRP3 inflammasome and the decline of IRGM in AR rats and MH-S cells. HPE regulates macrophage polarization through IRGM/ NLRP3 in AR.
Conclusions: HPE had protection for AR and the protection is achieved partly through suppressing M1 while promoting M2, the process which is mediated by IRGM via inhibiting NLRP3 inflammasome in AR
Clinical factors and hair care practices influencing outcomes in Central Centrifugal Cicatricial Alopecia
Authors: Onamusi Toluwalashe , Larrondo Jorge , McMichael Amy J. 
Published: December 2022

Abstract
Background.
Central centrifugal cicatricial alopecia (CCCA) is the most common form of primary scarring alopecia in women of African descent, negatively impacting their quality of life. Treatment is often challenging, and we usually direct therapy to suppress and prevent the inflammation. However, factors affecting clinical outcomes are still unknown.
Objectives.
To characterize medical features, concurrent medical conditions, hair care practices, and treatments used for patients with CCCA and assess their relationship with treatment outcomes.
Methods.
We analyzed data from a retrospective chart review of 100 patients diagnosed with CCCA who received treatment for at least one year. Treatment outcomes were compared with patient characteristics to determine any relationships. P-values were calculated using logistic regression and univariate analysis with 95% CI. P < .05 was considered significant.
Results.
After one year of treatment, 50% of patients were stable, 36% improved, and 14% worsened. Patients without a history of thyroid disease (P = 0.0422), using metformin for diabetes control (P = 0.0255), using hooded dryers (P = 0.0062), wearing natural hairstyles (P = 0.0103), and having no other physical signs besides cicatricial alopecia (P = 0.0228), had higher odds of improvement after treatment. Patients with scaling (P = 0.0095) or pustules (P = 0.0325) had higher odds of worsening. Patients with a history of thyroid disease (P = 0.0188), not using hooded dryers (0.0438), or not wearing natural hairstyles (P = 0.0098) had higher odds of remaining stable.
Conclusions.
Clinical characteristics, concurrent medical conditions, and hair care practices may affect clinical outcomes after treatment. With this information, providers can adjust proper therapies and evaluations for patients with Central centrifugal cicatricial alopecia.
Enbloc resection of primary oral cancer involving infratemporal fossa: A systematic “out to in and top to bottom” surgical approach and outcomes
Authors: Kumar Naveena AN , Dikhit Punit Singh , G Keshava rajan , Usman Nawaz , Shetty Preethi , Mehta Vedant , Gireesh Rinsha 
Published: December 2022

Abstract
Purpose:

The oral cavity Squamous Cell Carcinoma (OCSCC) involving infratemporal fossa (ITF) is considered as cT4b stage per AJCC 8th classification. The treatment of these group of patients is challenging due to the difficulty in achieving negative resection margin status. In this study we have highlighted our surgical technique with oncological outcome of enbloc resection of primary oral cancer involving ITF.

Methodology:

This was a single centre retrospective study which included only patients with OCSCC extending into ITF. Our surgical technique of systematic “out to in and top to bottom” approach was detailed. The perioperative outcomes, histopathological details, survival outcomes were measured.

Results:

Over the period of 1 year a total of 340 patients with OCSCC reported to our outpatient department, out of which 120 patients belonged to cT4 category and 32 patients were cT4b stage with involvement of ITF. Amongst 32 patients, 2 patients had distant metastasis and were excluded from the study. The 5 patients received neoadjuvant chemotherapy followed by surgery and rest all patients were taken up for upfront curative surgery. There were no significant intraoperative and postoperative complications. None of the margins were found to be involved or close in the final histopathology report. The median DFS and OS were 31 months and 27 months respectively at a median follow up of 29 months.

Conclusion:

Our systematic approach of enbloc resection of primary oral cancer involving ITF is safe and easily reproducible with high rate of negative resection margin status.
How Soon Do Metabolic Alterations and Oxidative Distress Precede the Reduction of Muscle Mass and Strength in Wistar Rats?
Authors: de Lima Malu Cristina de Araújo Montoro , Zazula Matheus Felipe , Martins Luiz Fernando , Carvalhal Stephanie Rubiane da Silva , Guimarães Ana Tereza Bittencourt , Fernandes Luiz Claudio , Naliwaiko Katya 
Published: December 2022

Abstract
Our objective was to investigate how metabolic changes, the antioxidant system and the accumulation of oxidative damage occur in muscles with different fibre populations during the ageing process of Wistar rats, as well as to try to map the key age at which these changes occur. For this, 30 male Wistar rats were euthanized aged 11, 15 and 19 months. Then, changes in energy metabolism, antioxidant system and oxidative damage in the soleus and extensor digitorum longus muscles were determined. In this sense, it was possible to observe that changes in body characteristics occur after 15 months of age. Regarding muscle biochemical alterations, we can observe that the soleus muscle presents alterations in protein and anaerobic metabolism only at 19 months, while the extensor digitorum longus presents these alterations at 15 months. Even with the different induction of the antioxidant system between the muscles, the damage accumulation is similar between the two muscles. Therefore, it is possible to conclude that at 15 months of age, the metabolic changes that lead to the reduction of muscle mass and strength found in ageing begin, being, therefore, a key age for the application of interventions that seek to curb the reduction of mass and muscle strength, promoting a better quality of life for individuals.