bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐term performance of unilateral zygomatic implants: A case series
Authors: Cea‐Arestín Pablo , Bilbao‐Alonso Arturo , Varela‐Centelles Pablo , Menéndez‐Lago Carolina , Seoane‐Lestón Juan 
Published: March 2023

AbstractThe aim of this investigation is to contribute to clarify whether zygomatic unilateral implants are a feasible alternative for the rehabilitation of the atrophic maxilla. Six consecutive, unilaterally edentulous patients who received zygomatic implants gave their consent to enter this retrospective observational study. Fixtures were inserted according to the Zygomatic Anatomy‐Guided Approach and loaded with functional screwed restorations. All patients were compliant with their scheduled follow‐up appointments. Six tapered implants were considered, mostly (80%) 4.4 mm diameter 40–50 mm long. These fixtures had been in place for an average of 4.1 years (range: 5–144 months). No implant failures were observed, and continuous fixed‐prosthesis function was achieved throughout the follow‐up period with no loosening or fracture of prosthetic screws. Patients were satisfied with the treatment and experienced only minor complications. Unilateral zygomatic implants seem to be a feasible alternative that diminishes morbidity and treatment times with high‐survival rates for patients with atrophic posterior maxilla.
The design roots of policy problems: Unpacking the role of procedural tools in design fitness and resilience
Authors: Virani Altaf , Bali Azad Singh , Cashore Benjamin , Howlett Michael , Ramesh M 
Published: March 2023

AbstractWhile policy design scholars have made significant conceptual and empirical advances in identifying and evaluating procedural tools, there has been a little focus on understanding how they interact with the more traditional “substantive” elements of a policy mix and their critical functions in policy mix designs. As a result, there is uncertainty about how procedural tools affect policy effectiveness—at adoption or over time. To address this gap, we propose a framework for deconstructing policy mix designs to examine how procedural tools interact with substantive tools in ways that either contribute to or undermine design “fitness” and “resilience.” The framework's diagnostic utility is illustrated by its application to unpack healthcare arrangements in Singapore and India, which reveals design “fault lines” that policy researchers and practitioners need to be aware of. We conclude by offering research directions for further investigating the role of procedural tools in shaping policy dynamics and outcomes.
Is swearing morally innocent?
Authors: de Vries Bouke 
Published: March 2023

AbstractSome philosophers believe that swearing is morally innocent insofar as it is non‐abusive and vulgarities are being used, such as when people exclaim “s**t!” or “f**k!” This article shows this view to be mistaken. I start by arguing that taking offense at non‐abusive vulgar swearing is not irrational, before arguing that, even if it were, such swearing would still not always be justified. The fact that many of us find it hard to overcome profanity‐induced offense, along with the fact that its existence is necessary for swearing to be possible, is sufficient to render even non‐abusive vulgar swearing sometimes wrong. I go on to assess the opposite view, according to which swearing, including non‐abusive vulgar swearing, is never justified, whereby two objections to this activity are addressed. According to the instrumentalization objection, the fact that swearing is possible only if at least some people are sometimes offended by the words that are used means that swearers treat those who are offended by their profanity as mere means. And according to the Ersatz objection, the fact that we can use inoffensive words to raise the emotional content of our speech renders swearing gratuitously offensive. Neither objection is found to be convincing.
Suicidal behaviors in patients with chronic physical illness: A test on the interpersonal theory of suicide
Authors: Shim Eun‐Jung , Jeong Donghee , Jung Saim , Oh Kook‐Hwan , Oh Byung‐Mo , Cho Hyun‐Jai , Hahm Bong‐Jin 
Published: March 2023

AbstractIntroductionThe unalleviated burden of chronic physical illness (CPI) increases the risk of suicidal behaviors (SB) in affected individuals. This study tested the interpersonal theory of suicide (ITS) in patients with CPI.MethodsPatients diagnosed with cardiovascular, cerebrovascular, and renal diseases were recruited from two hospitals in South Korea. Data from 257 participants who completed Time (T) 1 and T2 surveys were analyzed. Hierarchical regression analyses for passive and active suicide ideation (PSI and ASI), and suicide plans and attempts (SP and SA) at both time points were conducted.ResultsInterpersonal theory of suicide hypotheses were partially supported. Even accounting for factors such as depression, anxiety, and lifetime SA, some main and interaction effects of the ITS constructs explained SB in a cross‐sectional examination, but to a lesser degree in a longitudinal examination that controlled for T1 SB. PB was a consistent correlate of SB. TB was also relevant, as PB–SA association was significant among participants with high TB both times. ASI was associated with SP and SA at T1, and the ASI‐SP association at T1 was stronger at a high CS level.ConclusionsOverall, the results suggest the relevance of ITS constructs that warrant attention to prevent SB in patients with CPI.
The RhWRKY33a‐RhPLATZ9 regulatory module delays petal senescence by suppressing rapid reactive oxygen species accumulation in rose flowers
Authors: Jiang Liwei , Liu Kun , Zhang Tao , Chen Jin , Zhao Siqi , Cui Yusen , Zhou Wentong , Yu Yi , Chen Siyu , Wang Caiyuan , Zhang Changqing 
Published: March 2023

SUMMARYRedox homeostasis in plant cells is critical for maintaining normal growth and development because reactive oxygen species (ROS) can function as signaling molecules or toxic compounds. However, how plants fine‐tune redox homeostasis during natural or stress‐induced senescence remains unclear. Cut roses (Rosa hybrida), an economically important ornamental product worldwide, often undergo stress‐induced precocious senescence at the post‐harvest bud stage. Here, we identified RhPLATZ9, an age‐ and dehydration‐induced PLATZ (plant AT‐rich sequence and zinc‐binding) protein, and determined that it functions as a transcriptional repressor in rose flowers during senescence. We also showed that RhWRKY33a regulates RhPLATZ9 expression during flower senescence. RhPLATZ9‐silenced flowers and RhWRKY33a‐silenced flowers showed accelerated senescence, with higher ROS contents than the control. By contrast, overexpression of RhWRKY33a or RhPLATZ9 delayed flower senescence, and overexpression in rose calli showed lower ROS accumulation than the control. RNA‐sequencing analysis revealed that apoplastic NADPH oxidase genes (RhRbohs) were enriched among the upregulated differentially expressed genes in RhPLATZ9‐silenced flowers compared to wild‐type flowers. Yeast one‐hybrid assays, electrophoretic mobility shift assays, dual luciferase assays and chromatin immunoprecipitation quantitative PCR confirmed that the RhRbohD gene is a direct target of RhPLATZ9. These findings suggest that the RhWRKY33a‐RhPLATZ9‐RhRbohD regulatory module acts as a brake to help maintain ROS homeostasis in petals and thus antagonize age‐ and stress‐induced precocious senescence in rose flowers.
Synergistic effect of two formulations of hypochlorous acid in the treatment of 346 chronic ulcers
Authors: Herruzo Rafael , Fondo Alvarez Erika , Herruzo Irene , Santiso Casanova Emma , Cerame Perez Silvia 
Published: March 2023

AbstractOur objective was to assess the efficacy of two successive applications of hypochlorous acid, first as a liquid and then as a gel because liquid hypochlorous acid is effective but has little residual effect, while the gel form has more residual power, and compare it with that of other products. An experimental non‐randomised study was carried out, treating 346 chronic ulcers in 220 patients. The antiseptic treatment has been divided into ‘hypochlorous acid’ (Clortech), ‘hypochlorous acid liquid + gel’ (Clortech + Microdacyn60R‐hydrogel) and ‘Others’ (Prontosan or Chlorhexidine or Microdacyn60R‐hydrogel). Bivariate and multivariate studies analysed the characteristics of the patients and their ulcers, including size, symptoms, signs, treatments received and their duration, and so on. The ulcers were complicated, of long evolution, and most had a vascular origin. On average, antiseptic treatment lasted 14 weeks. At the time of their discharge, or last treatment in the clinics, 59% of the ulcers had healed completely, 9.5% worsened, and 6.9% had become infected during this period. In the bivariate and multivariate studies, we took as reference the ‘others’ treatments that showed no significant differences in healing time or infection rates compared withliquidhypochlorous acid 100–500 mg/L alone. However, hypochlorous acid liquid + gel showed a synergistic effect, with a higher probability of achieving complete healing (four times) and a lower probability of infection (a fifth), compared to the ‘other’ antiseptics. In conclusion, a synergistic effect was found with the successive application of hypochlorous acid in liquid followed by gel, an effect that increased healing probability and decreased the risk of the ulcer becoming infected.
Periconceptional alcohol alters in vivo heart function in ageing female rat offspring: Possible involvement of oestrogen receptor signalling
Authors: Dorey Emily S. , Headrick John P. , Paravicini Tamara M. , Wlodek Mary E. , Moritz Karen M. , Reichelt Melissa E. 
Published: March 2023

AbstractAlcohol exposure throughout gestation is detrimental to cardiac development and function. Although many women decrease alcohol consumption once aware of a pregnancy, exposure prior to recognition is common. We, therefore, examined the effects of periconceptional alcohol exposure (PC:EtOH) on heart function, and explored mechanisms that may contribute. Female Sprague–Dawley rats received a liquid diet ±12.5% v/v ethanol from 4 days prior to mating until 4 days after mating (PC:EtOH). Cardiac function was assessed via echocardiography, and offspring were culled at multiple time points for assessment of morphometry, isolated heart and aortic ring function, protein and transcriptional changes. PC:EtOH‐exposed embryonic day 20 fetuses (but not postnatal offspring) had larger hearts relative to body weight. Ex vivo analysis of hearts at 5–7 months old (mo) indicated no changes in coronary function or cardiac ischaemic tolerance, and apparently improved ventricular compliance in PC:EtOH females (compared to controls). At 12 mo, vascular responses in isolated aortic rings were unaltered by PC:EtOH, whilst echocardiography revealed reduced cardiac output in female but not male PC:EtOH offspring. At 19 mo, left ventricular transcript and protein for type 1 oestrogen receptor (ESR1), HSP90 transcript and plasma oestradiol levels were all elevated in female PC:EtOH exposed offspring. Summarising, PC:EtOH adversely impacts in vivo heart function in mature female offspring, associated with increased ventricular oestrogen‐related genes. PC:EtOH may thus influence age‐related heart dysfunction in females through modulation of oestrogen signalling.
Investigating Different Fluids and Injection Patterns on the Effect of Reservoir Rock Quality Alteration due to Swelling and Migration of Clay Minerals at Carbonate Reservoirs
Authors: Karami Mehran , Sedaee Behnam , Nakhaee Ali 
Published: March 2023

Abstract
Nowadays, with the progress in technology, the demand for fossil fuels has increased. Therefore, improving the oil recovery from the current oil reservoir is among the crucial issues. Formation damage is a well-recognized subject that causes a reduction in the productivity or injectivity of an oil well. Reducing or controlling formation damage can be effective in improving oil recovery. There are various mechanisms that cause formation damage such as fine migration and clay swelling. In this study, the simultaneous effect of fine migration and swelling on the permeability of a carbonate rock was investigated. Kaolinite and smectite(bentonite) minerals were selected as the representative case for migration and swelling, respectively. Primarily, bottle tests were conducted to study the effect of different fluids on the swelling potential of the kaolinite and smectite. According to the structural feature of the kaolinite, it has the smallest cation exchange capacity (CEC) and consequently a low swelling tendency. Therefore, it showed negligible swelling in the presence of all fluids. According to the high cation concentration of the formation water (FW) and seawater (SW), smectite did not show a high swelling effect. However, diluting the FW and SW increased the swelling tendency of the bentonite. Nanoparticles were not able to control the swelling of the bentonite according to their larger size than the spacing of clay layers. Zirconium oxychloride was also utilized as the swelling inhibitor which showed high efficiency. Eventually, different injection scenarios were tried using synthetic carbonate core samples with specific clay contents, and the best injection plan for formation damage control was determined.
2 Developing a new model to investigate the mechanobiology of primary blast in soft tissue
Authors: Staruch RMT , Sedman A , Macildowie S , Cork L , Cleveland RO , Snelling S , Thompson M , Rickard RF , Spear AM 
Published: March 2023

IntroductionEfforts to understand the pathology resulting for explosions, such as terrorist bombings or industrial accidents, are increasingly focused on connecting biophysical stimuli with cell fate, widely referred to as mechanobiology. This work presents a novel mechanobiologically relevant biomimetic in vitro 3D muscle model of blast injury together with a custom shock tube designed to deliver relevant explosive loading to cell culture together with analysis of the high throughput whole genome RNA sequencing detailing the effect of explosive shock waves on cell culture over timeMethodImmortalised mouse skeletal muscle cells were encapsulated in fibrin hydrogels and cast between custom-made 3D printed flexible posts. Custom silicone tissue culture plates were designed and fabricated to enable the exposure of cultured skeletal muscle hydrogels (SkmH) to live explosive shock waves. In brief, a frustum shock tube (FST) facility was designed and built at Dstl to delivery relevant loading to a standard tissue culture well plate.A three-arm explosive trial utilising SkmH was then conducted. After exposure SkmHs were evaluated at 1 hour, 1 day, 3 day and 7 days post blast for cell metabolic activity (presto blue assay), and stored for subsequent gene expression analysis (RNA later solution), imaging (fixation in 4% paraformaldehyde then PBS) and serum contents (media frozen & stored).ResultsSkmHs cultured between 3D printed posts demonstrated aligned morphology, expressed markers consistent with myotube formation and contractile properties from post deflection. SkmHs exposed to explosive blast demonstrated dose-dependent metabolic changes.ConclusionThis work outlines the design and development of a mechanosensitive apparatus for probing the cellular effects of blast shock wave on biomimetic tissue culture models. Metabolic data up to one week after exposure gives new and detailed insight into the cellular signalling after blast in skeletal muscle.
7 Towards 3D printed medical devices in vivo
Authors: James Fong M , Baldock Sara J , Cheneler David , Appleby John B , Hardy John G 
Published: March 2023

IntroductionThe rapid development of wearable/implantable electronic devices for biomedical applications is exciting. Telemedicine methods of personal identification and/or patient medical information directly embedded within an individual may revolutionise civilian/military healthcare, motivating the development of minimally invasive methods to print a variety of components in vivo. Potential applications include electronic devices for communications or identification, or optically-readable tags, such as barcodes and QR codes for data storage, personnel identification or medical history.MethodWe utilise a novel photochemical approach for the additive manufacture of embedded polymer components with wide-ranging biomedical applications, with the demonstrated potential for 3D printing of electronic components in vitro, ex vivo and in vivo. Custom ink formulations are applied/delivered to a substrate (material/tissue/organism) followed by photochemical development of the ink within the substrate yielding de novo designed electronic components within/on the substrate characterised by a variety of analytical methods (e.g., electrical/microscopy/spectroscopy).ResultsWe demonstrate progress towards complex electrical devices, with the fabrication of conductive polymer wires, which can form the foundation of all subsequent larger electrical devices. Subsequently, the successful printing of a functioning quick response (QR) code is demonstrated, enabling information to be embedded and easily characterised. Further measurement of this device with an optical microscope shows the ability to store information ex-vivo with a simple characterisation technique, and shows promise for effective 3D printed devices for medical applications in-vivo.ConclusionFacile printing of devices for electronic characterisation, or optical components for characterisation with a conventional camera paves the way for a next generation of embedded bioelectronics that we foresee revolutionizing healthcare via personalised telemedicine.
IQOS print magazine advertising characteristics and reach before and after FDA authorisation as a modified risk tobacco product
Authors: Ganz Ollie , Strasser Andrew A , Giovenco Daniel P , Audrain-McGovern Janet , Cappella Joseph N , Safi Zeinab , Tan Andy S L , Talbot Eugene M , Delnevo Cristine D 
Published: March 2023

Introduction
IQOS is a heated tobacco product that was authorised as a modified risk tobacco product (MRTP) in July 2020. While it was removed from the US market in 2021 for legal reasons, as the first tobacco product to receive an ‘exposure modification’ MRTP order, surveillance of IQOS marketing is needed to inform regulation and policy for future MRTPs. The purpose of this study is to expand the current research on IQOS advertising in the USA by examining content and readership characteristics of IQOS ads in print magazines before and after US Food and Drug Administration MRTP authorisation.

Methods
We merged content analysis data with Kantar Media data on magazine placement and expenditures. Magazine readership data were obtained from MRI-Simmons. We compared data from pre-MRTP authorisation with data post-MRTP authorisation. This study was conducted in 2021.

Results
There was one unique ad and there were 13 observations pre-MRTP, and eight unique ads and 132 observations post-MRTP. Compared with pre-MRTP ads, more post-MRTP ads featured Marlboro HeatSticks, including Amber HeatSticks, and featured people. All ads contained a warning label—most warning labels were cigarette specific. IQOS ads were featured in magazines that are especially popular among women.

Conclusions
After receiving MRTP authorisation, IQOS increased ad expenditures in print magazines with a readership comprised of primarily women. If IQOS returns to the US market, it will be important for tobacco control to monitor their advertisement content, placement, and expenditures.
Horizon fractalization in black strings ungravity
Authors: Carvalho Í. D. D. , Furtado J. , Landim R. R. , Alencar G. 
Published: March 2023

AbstractIn this paper, we study the scalar (tensor) and vector unparticle corrections for cosmic and black strings. Initially, we consider a static cosmic string ansatz from which we obtain the solution in terms of first- and second-kind Bessel functions. We also obtain the solution for a black string in the unparticle scenario. We identify two regimes, namely, a gravity-dominated regime and an ungravity-dominated regime. In the gravity-dominated regime, the black string solution recovers the usual solution for black strings. The Hawking temperature is also studied in both regimes. As in the static and rotating black hole, we find a fractalization of the event horizon. This points to the fact that fractalization is a natural consequence of unparticles. Finally, we study the thermodynamics of the black string in the ungravity scenario by computing the entropy, heat capacity, and free energy. For both cases, we find that, depending on the region of the parameter $$d_U$$

d
U

, phase transitions are possible.
Alignment of the Alpha Magnetic Spectrometer (AMS) in space
Authors: Yan Qi , Choutko Vitaly 
Published: March 2023

AbstractThe Alpha Magnetic Spectrometer (AMS) is a precision particle physics detector operating at an altitude of $$\sim 410$$

∼
410

km aboard the International Space Station. The AMS silicon tracker, together with the permanent magnet, measures the rigidity (momentum/charge) of cosmic rays in the range from $$\sim 0.5$$

∼
0.5

GV to several TV. In order to have accurate rigidity measurements, the positions of more than 2000 tracker modules have to be determined at the micron level by an alignment procedure. The tracker was first aligned using the 400 GeV/c proton test beam at CERN and then re-aligned using cosmic-ray events after being launched into space. A unique method to align the permanent magnetic spectrometer for a space experiment is presented. The developed underlying mathematical algorithm is discussed in detail.
The CMSSM survives Planck, the LHC, LUX-ZEPLIN, Fermi-LAT, H.E.S.S. and IceCube
Authors: Ellis John , Olive Keith A. , Spanos Vassilis C. , Stamou Ioanna D. 
Published: March 2023

AbstractWe revisit the viability of the CMSSM, searching for regions of parameter space that yield a neutralino dark matter density compatible with Planck measurements, as well as LHC constraints including sparticle searches and the mass of the Higgs boson, recent direct limits on spin-independent and -dependent dark matter scattering from the LUX-ZEPLIN (LZ) experiment, the indirect constraints from Fermi-LAT and H.E.S.S. on dark matter annihilations to photons in dwarf spheroidal galaxies and the Galactic Centre, and the IceCube limits on muons from annihilations to neutrinos in the Sun. For representative values of $$\tan \beta $$

tan
β

and $$A_0$$

A
0

we map in detail the Planck-compatible strips in CMSSM parameter planes, which exhibit multiple distinctive features for large $$\tan \beta $$

tan
β

, $$A_0 = 0$$

A
0

=
0

and $$\mu > 0$$

μ
>
0

, and identify portions of the strips that survive all the phenomenological constraints. We find that the most powerful constraint is that from $$m_h$$

m
h

, followed by the LZ limit on spin-independent scattering, whereas sparticle searches at the LHC and indirect dark matter searches are less restrictive. Most of the surviving CMSSM parameter space features a Higgsino-like dark matter particle with a mass $$\sim 1000{-}1100$$

∼
1000
-
1100

GeV, which could best be probed with future direct searches for dark matter scattering.