bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for malignant oral mucosal lesion development (literature review). Part 1. Endogenous and biological factors
Authors: Lunitsyna Yu. V. , Lazarev A. F. , Tokmakova S. I. , Bondarenko O. V. 
Published: September 2023

Relevance. Oral mucosal cancer (OMC) is the sixteenth most common cancer worldwide. The high mortality rate is mainly due to the asymptomatic course of the disease in the early stages and late detection when the tumour process poorly responds to treatment. Determining the impact of various risk factors and establishing their relationship are necessary to prevent and diagnose malignant oral mucosal lesions in the early stages.Purpose. Based on the modern literature, the study aimed to determine the impact value of various internal and external risk factors on malignant oral mucosal lesion development and assess the risk factors’ relationship.Material and methods. The research material included the analysis of literature from databases – Elsevier, PubMed, Elibrary, Google Academy, Medline and Cyberleninka. The study included literature sources in Russian and English.Results. Based on modern literature, we have determined endogenous and biological risk factors for malignant oral mucosal lesion development. The study noted the high role of microbiome changes and the presence of dysbiosis in patients with malignant neoplasms and proved the direct involvement of Candida fungi in carcinogenesis. The development of oral mucosal cancer and the presence and severity of oral yeast colonization and human papillomavirus infection showed a positive correlation. Chronic oral diseases, which are susceptible to malignant transformation or contribute to the development of carcinomas, have been identified, and their relationship has been established with biological risk factors, age, sex of the patient and duration of the disease course.Conclusion. The studies considered in this part of the review prove the influence of endogenous and biological factors on the development of malignant neoplasms of the oral cavity and determine their relationship. However, many mechanisms remain unexplored to date. Effective primary and secondary prevention implementation needs improvement and the development of a multidisciplinary approach to research methodology, study the complex impact of all groups of risk factors on the development of malignant oral mucosal lesions.
Evaluation of surgical characteristics and clinical outcome of 11 patients with thoracic discectomy through transfacet approach
Authors: Ovalioglu Talat Cem 
Published: September 2023

Background: In thoracal disc herniation (TDH) requiring surgery, the size, level, anatomic location, and calcification of the disc are extremely important in the selection of the technique to be applied. Since the thoracic region does not allow spinal cord manipulation, the surgery is difficult and requires experience. A consecutive series of patients who underwent thoracic discectomy through a posterior transfacet approach is presented in this study.
Methods: Eleven patients (6 men, and 5 women) underwent surgery at 12 disc levels. The mean age was 53.54 years (range 28-72 years). Patients presented with myelopathy (n = 8, 73%), radiculopathy (n = 7, 64%), back pain (n =10, 91%), and urinary dysfunction (n = 6, 55%). Seven (58%) lateral, 3 (25%) calcified, and 4 (33%) large disc herniations were revealed by preoperative imaging. The mean follow-up period was 21.02 ± 8.04 months (range 6 – 43 months).
Results: A posterior transfacet approach was used for all eleven patients with TDH. Thoracic discectomy was performed at T11- 12 (36%) level for 4 patients, and equally at T10- 11 (36%) level for the other 4 patients. A bilateral approach with laminotomy was performed in one patient, and a two-level discectomy was performed in another patient. Unilateral partial laminectomy was added for 3 patients. The average operating time was 146.85 minutes (range 125-220 minutes). The average hospital stay was 4.2 days (range, 2- 13 days) while no neurological functional deterioration was observed in any of the patients after surgery. Postoperative 1-month and 6-month ODI scores were found significantly different from preoperative ODI scores in all patients.
Conclusions: Thoracal discectomy through the posterior transfacet approach route is a safe and effective technique to achieve adequate decompression without requiring instrumented fusion.
Epidemio-clinical and therapeutic profile of non-traumatic medullary-radicular compressions at the University Hospital of Kinshasa
Authors: Maoneo Israël , Beltchika Antoine , Ketani Teddy , Ntsambi Glennie 
Published: September 2023

Context and objectives. As the world's population ages, non-traumatic medullary-radicular compressions are becoming more common. This work aims to describe their epidemio-clinical and therapeutic aspects at the University Hospital of Kinshasa.
Methods. It is a descriptive cross-sectional study from 2016 to 2022 concerning 61 cases. Variables of interest included: sex, age, cause, level of lesion, ASIA score, treatment, complications, and destination. Data were analyzed using SPSS 26 and STATA 16 software.
Results. One hundred and twenty patients were operated on for medullary-radicular compression, including 61 non-traumatic (50.8%) and 59 traumatic (49.2%). Among the non-traumatic, 31 patients were male (50.8%) and 30 females (49.2%). The average age was 51.51 ± 14.21 years. Patients between the ages of 40 and 69 accounted for 68.8%. The annual curve was increasing. On admission, the clinical presentation was dominated by an incomplete neurological deficit (67.2%). The mean time to diagnosis was 188.57 days. Degenerative pathologies (63.9%) including 31 herniated discs (79.4%) and 8 cases of canal narrowing (20.6%) predominated, followed by tumors 14 (22.9%) half of which included metastases. The most performed surgical procedures included decompression laminectomy (26.2%), laminectomy-discectomy (24.5%) and laminectomy-arthrodesis (32.7%). The postoperative course was unremarkable in 67.2%, except for 15 cases of surgical site infection (24.6%) and 3 deaths (4.9%). ASIA score on dischached improved in 62.7% (p<0.001). Only 2 patients (9.8%) continued their treatment in a rehabilitation centre.
Conclusion. Non-traumatic medullary-radicular compressions are frequent in the service, more caused by herniated discs and tumours. Both sexes are equally affected and the age group is ranging from 40 to 69 years. The neurological deficit is often incomplete cord injury. Laminectomy, discectomy and arthrodesis are commonly performed. The postoperative outcome is generally better.
Les Sephardim, les Marranes, les Inquisitions péninsulaires et leurs archives dans les travaux récents de I.-S. Révah
Authors: Nahon Gérard 
Published: September 2023

Compte rendu d'articles et de cours professés au Collège de France et à l'École Pratique des Hautes Études de 1966 à 1973.
I. — Les Sephardim et la version traditionnelle de la Bible. Dès le Moyen Age, les Juifs se donnèrent en Espagne une version de la Bible en langue vulgaire, plus exactement en une «langue artificielle» calquée sur l'hébreu. L'étude des «témoins» tardifs (d'abord la Bible imprimée à Ferrare en 1553) permet-elle de remonter à la version traditionnelle de la Bible des Juifs d'Espagne ?
II. — Les Marranes : familles et groupements, pratique religieuse et croyances, littérature. Les Juifs convertis de force au Portugal en 1497 donnèrent naissance à un marranisme dont les péripéties sont suivies à travers des recherches sur les familles d'Uriel da Costa, Baruch de Spinoza, Antonio Enriquez Gómez, Joäo Pinto Delgado, Duarte Dias.
III. — Les Archives inquisitoriales et l'Histoire : épistémologie et méthodologie. Quel crédit l'historien peut-il accorder aux archives de l'Inquisition ? Contre les thèses se réclamant du marxisme de M. António José Saraiva, M. I.-S. R. démontre que l'Inquisition procédait selon des canons qui lui étaient propres et que ses archives peuvent être utilisées pour reconstruire l'histoire de ses victimes. Elles attestent la préservation parmi les Nouveaux Chrétiens d'un judaïsme peut-être appauvri mais vivace. L'explication par un mécanisme économique doit être rejetée.
Le Sēfer Yezīrā. L'édition critique, le texte primitif, la grammaire et la métaphysique
Authors: Séd Nicolas 
Published: September 2023

Le status quaestionis du Sēfer Yezīrā d'après trois études récentes :
I. Gruenwald propose une édition critique de ce livre en se fondant essentiellement sur un manuscrit du Xe siècle (ms. Vatican, Cat. Assemani 299 [8], fos 66a-71b) de la recension longue. C'est une contribution remarquable à l'étude des leçons les plus anciennes, mais elle appauvrit le corpus de ce livre en cherchant à ramener les trois recensions à une formule unique. Une édition critique, présentant ces trois recensions parallèlement, semble être la seule solution à retenir.
I. Weinstock établit également un texte critique du premier chapitre de ce livre. Il veut en retrouver la structure archaïque et en rétablir même la forme littéraire primitive. Sa reconstitution ne présente aucune garantie d'authenticité.
N. Allony étudie les fragments d'une grammaire très ancienne qui figure actuellement au IIe chapitre de ce livre. Il démontre les analogies frappantes avec le Kitāb al-1 Ain, œuvre du premier lexicographe arabe, Halīl Ibn Ahmad (ob. 175/797). La source des grammaires de ce type serait à rechercher chez les grammairiens indiens de l'école de Panini.
Utilizing Blockchain Technology for Enhanced Governance: A Comprehensive Analysis of Potential Applications and Innovations in the Governmental Sector of the EU
Authors: Bodemer Oliver 
Published: September 2023

<p>This research delineates the transformative potential of blockchain technology within the realm of European governments. By conducting a meticulous analysis of existing literature and case studies, the study seeks to identify and evaluate the opportunities and challenges associated with implementing blockchain technology in governmental operations across Europe. The methodology involves a comprehensive review of peer-reviewed articles, white papers, and governmental reports, aiming to construct a nuanced perspective on the current state of blockchain applications in European governmental structures. Key findings indicate that blockchain technology can significantly enhance transparency, efficiency, and security in governmental processes within the European context, albeit with certain challenges and barriers to implementation. This study serves as a pivotal reference point, fostering a deeper understanding of the intricate dynamics of blockchain technology in the European governmental sphere and paving the way for future research and policy developments. </p>
OPTIMALISASI LAYANAN JASA LAUNDRY PADA APLIKASI (E-LAUNDRY) BERBASIS MOBILE
Authors: Fera Fera Yuliana , Rohmah Mimin Fatchiyatur , Ardiantoro Luki 
Published: September 2023

Dalam rutinitas sehari- hari yang sibuk dan padat, layanan jasa laundry memiliki peranan penting. Penelitian ini bertujuan untuk memperbaiki dan mengoptimalkan layanan jasa laundry dengan penekanan pada efisiensi dan kualitas tinggi. Dalam era kehidupan modern, aplikasi layanan jasa laundry telah menjadi solusi yang popular, membantu pengguna dalam memesan dan melacak status laundry secara mudah. Penelitian ini menerapkan metode analisis dan perancangan dengan fokus pada anailisi berorientasi objek. Sistem dirancang dengan menggunakan sistem flow dan DFD (Data Flow Diagram). Untuk desain sistem, menggunakan figma, sementara implementasi aplikasi dilakukan dengan framework Android Studio dan menggunakan database MySQL untuk menyimpan data. Dalam pengembangan aplikasi,fitur GPS telah diintegrasi untuk membantu pelanggan dan pegawai laundry dalam navigasi dan pelacakan yang efisien. Pada tahap evaluasi, aplikasi E-Laundry diuji menggunakan metode blackbox, dan survei dilakukan kepada pengguna melalui kuesioner. Hasil evaluasi menunjukkan presentase sebesar 87% bahwa pengguna merasa puas dengan kemudahan pengguna dan kualitas layanan yang disediakan oleh aplikasi E- Laundry. Hasil survei menunjukkan bahwa dari total keseluruhan pengujian kuesioner menilai aplikasi dengan baik.
Kata kunci: aplikasi, android, layanan, laundry, blackbox
PENGARUH PERMAINAN GOBAK SODOR TERHADAP KERJASAMA ANAK KELOMPOK B TK INTAN SARI PALANGKA RAYA TAHUN AJARAN 2019/2020
Authors: Adminpintarharati  
Published: September 2023

ABSTRAK
Kerjasama (coorperation), yaitu sikap mau bekerjasama dengan kelompok. Anak yang berusia dua atau tiga tahun belum berkembang sikap kerja samanya. Mulai usia tiga tahun akhir atau empat tahun, anak sudah mulai menampakkan sikap kerja samanya dengan anak lain. Pada usia enam atau tujuh tahun, sikap kerja sama ini sudah berkembang dengan lebih baik lagi. Namun, sebagian anak masih belum dapat bekerjasama dengan temannya dan juga tidak bisa berbagi dalam kelompok terlihat dalam hal mengerjakan tugas kelompok anak masih berebutan potongan kertas, lem, gambar dalam kegiatan kolase dan saling berebut bermain balok. Anak tidak terlihat aktif, terlihat dari kurangnya interaksi anak ketika menyelesaikan tugas kelompok, anak tidak mau membantu mengerjakan tugas kelompok bahkan hanya melihat temannya bekerja. Penelitian ini dilakukan untuk mengetahui pengaruh permainan gobak sodor terhadap kemampuan kerjasama anak. Penelitian ini merupakan penelitian kuantitatif metode eksperimen. Sampel adalah anak kelompok B TK Intan Sari Palangka Raya yang berjumlah 17 orang. Data dikumpulan dengan lembar observasi yang berisi 3 aspek. Hasil penelitian menunjukkan bahwa nilai thitung adalah 5,85, ttabel dengan taraf signifikan yaitu 5% (2,120). thitung 5,85 > ttabel 2,120. Berdasarkan hasil tersebut maka Ho ditolak dan Ha diterima. Sehingga dapat disimpulkan bahwa hasil penelitian Permainan Gobak Sodor Berpengaruh Terhadap Kemampuan Kerjasama pada Anak Kelompok B TK Intan Sari Palangka Raya tahun Ajaran 2019/2020.

Kata Kunci: Permainan, Kerjasama, Anak Usia Dini
PERAN PENGASUHAN AYAH TERHADAP KEMANDIRIAN ANAK USIA DINI DI KELURAHAN MENTENG
Authors: Martono Wahyuni Christiany , Balimulia Sophia Oktavia 
Published: September 2023

Kemandirian yang dimiliki oleh anak usia dini adalah anak yang dapat mengerjakan sendiri segala tugas-tugas rutinnya seperti makan sendiri, memasang pakaian sendiri, selalu aktif dan bersemangat. Bertanggung jawab, mampu berfikir dan berbuat untuk diri sendiri, dan mempunyai kontrol yang kuat sesuai dengan usianya. Penelitian ini bertujuan untuk mengetahui peran pengasuhan ayah terhadap kemandirian anak usia dini di Kelurahan Menteng.Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif dengan teknik pemilihan sampel dalam penelitian ini menggunakan teknik purposive sampling. Teknik analisis pada penelitian ini menggunakan uji regresi linier sederhana. Subjek pada penelitian ini adalah ayah yang mempunyai anak usia 5-6 tahun di Kelurahan Menteng yang berjumlah 32 orang.Hasil penelitian diperoleh dari perhitungan uji validitas dan reliabilitas dengan nilai thitung sebesar 5,591 dibandingkan ttabel 2,042. Taraf signifikan dalam penelitian ini adalah 0,05 dengan a/2 : n-k-1, maka nilai ttabel adalah 2,042. Jadi nilai thitung (5,591) > ttabel (2,042). Berdasarkan hasil tersebut maka Ha diterima Ho ditolak. Artinya terdapat pengaruh peran pengasuhan ayah terhadap kemandirian anak usia dini di Kelurahan Menteng.
Kata Kunci : Peran Pengasuhan Ayah, Kemandirian, Anak Usia Dini
Dhima za Tasifida Kimuktadha katika Nyimbo za Singeli: Mifano kutoka kwa Msanii Msaga Sumu na Manfongo
Authors: Sikuomba Baraka , Godfrey Lina 
Published: September 2023

Kutokana na ufinyu wa tafiti zilizofanyika kuhusu tasifida katika muktadha wa nyimbo za singeli kumejengeka mtazamo hasi hasa kwenye lugha inayotumika katika muktadha wa nyimbo za singeli miongoni mwa wanajamii. Kutokana na umuhimu wa tasifida katika kuendeleza utamaduni wa jamii kulikuwa na haja ya kuchunguza na kuweka bayana dhima za matumizi ya tasifida katika nyimbo za singeli. Kwa hiyo, makala hii imeangalia dhima za tasifida kimuktadha katika nyimbo za singeli kwa kutumia nyimbo ziitwazo “Siponaye”, “Dada Asha”, “Spesho”, “Mtoto Mdogo” za msanii Msaga Sumu na “Chawa”, “Hainogi”, “Kitasa”, “Mashine” “Kipusa”, “Muacheni Adange” za msanii Manfongo. Nadharia ya Semiotiki imetumika kufafanua dhima za tasifida katika nyimbo za wasanii teule. Katika nyimbo hizo tasifida mbalimbali zimetumiwa na wasanii teule kuwasilisha maudhui yao. Nyimbo hizi za singeli, licha ya kuimbwa kwa lugha inayoonekana ni ya mtaani, zimezingatia sana matumizi ya tasifida katika kupunguza ukali wa maneno. Matokeo ya utafiti huu yameonesha wazi kuwa matumizi ya lugha ya tasifida katika nyimbo za singeli, yameonesha wazi kwamba nyimbo za singeli zina dhima kadha wa kadha zinazowasilishwa kwa njia ya matumizi ya tasifida. Kupitia matumizi ya tasifida katika nyimbo za singeli, ni bayana kwamba tasifida zina dhima za msingi katika nyimbo za singeli katika kuendeleza mila, utamaduni na desturi za mawasiliano katika jamii. Dhima hizo ni pamoja na kubainisha kazi zisizo halali katika jamii, kuibua tabia zisizokubarika katika jamii, kukemea mmomonyoko wa maadili katika jamii, kuhimiza umuhimu wa mapenzi ya dhati katika jamii na kuweka bayana uhalisia wa mwanaume. Hivyo basi, watafiti wengine wanaweza kufanya utafiti kama huu kwa kuchunguza kwa kina tofauti ya tasifida na taswira kimuktadha katika nyimbo teule za utafiti huu
The left–right reversed visual feedback of the hand affects multisensory interaction within peripersonal space
Authors: Mine Daisuke , Narumi Takuji 
Published: September 2023

AbstractThe interaction between vision and touch, known as the crossmodal congruency effect, has been extensively investigated in several research studies. Recent studies have revealed that the crossmodal congruency effect involves body representations. However, it is unclear how bodily information (e.g., location, posture, motion) is linked to visual and tactile inputs. Three experiments were conducted to investigate this issue. In Experiment 1, participants performed a crossmodal congruency task in which both their hand appearance and the motor trajectories were left–right reversed. The results showed that the crossmodal congruency effect was not observed in the reversal condition, whereas participants showed significant crossmodal congruency in the control condition, in which there was no visual manipulation of the hand. In Experiments 2 and 3, where either the hand appearance or motor trajectory was left–right reversed individually, a significant crossmodal congruency effect was observed. This study demonstrated that visual manipulation of hand appearance and motor trajectories both affected the crossmodal congruency effect, although neither showed a dominant effect that solely altered the crossmodal congruency effect. The present results provide insights into the relationship between visual-tactile interactions and bodily information.
Up-regulation of TIMP-2 expression promotes SHI-1 leukemic cells proliferation and infiltration in immunodeficiency mice
Authors: Li Zhenjiang , Chen Zixing , Cen Jiannong , He Jun , Qiu Qiaocheng , Xue Yongquan 
Published: September 2023

BackgroundMMPs and TIMPs play important roles in tumor angiogenesis and invasion. Studies have shown that TIMP-2 has two roles in tumor invasion. However, its role in leukemic infiltration has not been well investigated. This study explored the roles of TIMP-2 in extramedullary infiltration of acute monocytic leukemic SHI-1 cells bothin vitroandin vitro.MethodsA retroviral vector carrying the human TIMP-2 cDNA was constructed and transfected into the monocytic leukemic cell line SHI-1. The expression of TIMP-2 in the positive clones was determined. The proliferation of SHI-1 cells was examined by MTT assay. Trans-Matrigel invasion assays were used to investigate the infiltration abilityin vitro. SHI-1 cells were intravenously injected into pre-treated nu/nu mice to investigate the infiltration ability featurein vitro.ResultsThe expression of TIMP-2 on the cell membrane was significantly elevated in SHI-1/TIMP-2 cells. Overexpression of TIMP-2 promoted the cells proliferation and the invasionsin vitro. The SHI-1/TIMP-2 cells demonstrated higher infiltration ability when intravenously injected into nu/nu mice.ConclusionOver-expression of TIMP-2, especially on the cell membrane, may play important roles in promoting the proliferation and infiltration of SHI-1 leukemic cells.
Clinical manifestation of the SRSF2 gene mutation in Chinese patients with chronic myelomonocytic leukemia
Authors: Sun Chao , Zhang Sujiang , Qiao Chun , Yang Xiangchou , Li Jianyong 
Published: September 2023

Background
Spliceosome mutations have been recently identified and associated with hematological malignancies. SRSF2, one of components of the splicing machinery, has a high mutation frequency during chronic myelomonocytic leukemia, according to previous reports. However, the relevance of this finding in Chinese populations remains unknown.

Methods
We recruited 50 Chinese patients with chronic myelomonocytic leukemia to analyze the state of SRSF2 and to assess the corresponding clinical features by polymerase chain reaction followed by direct sequencing.

Results
Ten of 50 patients (20%) harbored SRSF2 mutations, including five P95R, two 95H, and three P95L point mutations. The patient group was older than the wild type group (P <0.01). No significant statistical differences were observed with regard to the other clinical characteristics (sex, peripheral blood count, serum lactate dehydrogenase, karyotype, World Health Organization classification, etc.) between these two groups. Two of the patients showed an early evolution to acute myeloid leukemia.

Conclusions

SRSF2 mutations are frequent in chronic myelomonocytic leukemia patients, but show a relatively lower incidence in Chinese patients. Moreover, the mutation can be related to old age and an unfavorable prognosis. Our results provide valuable insights for the development of a diagnostic marker, or for the identification of a therapeutic target for chronic myelomonocytic leukemia.