bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, awareness, treatment and control of hypertension in the Brazilian population: National Health Survey
Authors: Vieira Maria Alice Souza , Tonaco Luís Antônio Batista , Souza Maria José Silva , Andrade Flávia Cristina Drumond , Malta Deborah Carvalho , Felisbino-Mendes Mariana Santos , Velasquez-Melendez Gustavo 
Published: September 2023

Abstract
Introduction: Arterial Hypertension (AH) is the main risk factor for cardiovascular diseases and more recent studies that estimated the prevalence of this condition considering aspects such as awareness of diagnosis, treatment, and control, revealing alarming results in the global scenario.
Objective: To estimate the prevalence of awareness, treatment and control of hypertension in the Brazilian adult population and the sociodemographic factors associated with these outcomes.
Methodology: Cross-sectional population-based study with data from the National Health Survey. Outcomes were defined based on blood pressure measurements, self-reported diagnosis of AH and use of antihypertensive medication. We estimated the prevalence of the outcomes and the associations were subsequently tested by calculating prevalence ratios using Poisson regression.
Results: The prevalence of AH in the Brazilian population was 32.3%. Approximately 60.8% were aware of the diagnosis, 90.6% were taking drug treatment and, of these, 54.4% had controlled AH. Female gender and older age were associated with greater awareness, treatment and control. Other factors such as having a partner, health insurance, living in the urban area, race/color and schooling were also associated with outcomes.
Conclusion: Awareness and control of AH in Brazil can still improve in view of the SUS health programs. The differences found reflect socioeconomic inequalities and reveal groups with lower performance.
Efficacy and Safety of Bariatric Surgery Versus Non-surgery in the Treatment of Idiopathic Intracranial Hypertension: a Systematic Review and Meta-analysis
Authors: Teng Haiying , Wang Zilan , Wang Dongwei , Chen Huiru , Ni Hanyu , Chen Zhouqing , Hu Tong , Wang Zhong 
Published: September 2023

Abstract
Background
Idiopathic intracranial hypertension (IIH) is a debilitating disorder characterized by elevated intracranial pressure (ICP). Women, reproductive age, and obesity, especially weight gain in a short period, are major risk factors in the development of IIH. Weight loss has been widely recognized as a beneficial strategy of treatment.
Methods
Two researchers independently and systematically searched the National Library of Medicine (PubMed/MEDLINE), the Cochrane Library, EMBASE databases, and ClinicalTrials.gov to identify articles that met the eligibility criterion. The primary outcomes are ICP and IIH-related symptoms (number of patients with headache and visual defect), and secondary outcomes are weight, body mass index (BMI), ophthalmological examination, complications and mortality at the final follow-up.
Results
Eventually, 1 RCT, 6 retrospective studies and 17 case reports were included in the meta-analysis. The number of patients with headaches (P = 0.01) after surgery was significantly lower than that in the nonsurgery group. ICP (P = 0.005) was reduced significantly in the bariatric surgery group. Weight (P = 0.004) and BMI (P < 0.00001) were significantly lower in the bariatric surgery group. However, there was no significant difference in visual symptoms between the two groups. Overall, the probability of complications is not high.
Conclusions
Our research indicated that bariatric surgery is an effective and safe treatment for patients with IIH. Bariatric surgery can effectively reduce ICP and relieve headache, which is the major distress of patients.
Causal Relationship Between Gut Microbiota and Gynecological Tumor:A Two-Sample Mendelian Randomization Study
Authors: Xiong Yajun , Zhang Xiaonan , Niu Xiaoya , Zhang Long , Jia Junli , Xu Aiguo 
Published: September 2023

Abstract
Background: Previous research has linked alterations in the composition of the gut microbiota to a variety of gynecologic tumors.Nevertheless, although the causal relationship between the gut microbiota and gynecologic tumors remains to be fully elucidated. Therefore, this study uses a two-sample Mendelian randomization analysis (MR) to explore the causal correlation between the gut microbiota community and prevalent gynecologic tumours. With the goal of identifying specific pathogenic bacterial communities that may be involved in gynecologic tumor development.
Materials and Methods: We utilized data from the MiBioGen consortium’s Genome-Wide Association Study (GWAS) on gut microbiota as the exposure variable. Four common gynecologic neoplasms including uterine fibroids (UF), endometrial cancer (EC), ovarian cancer (OC) and cervical cancer (CC) were selected as the outcome variables. Single-nucleotide polymorphisms (SNPs) significantly associated with exposure were selected as the instrumental variables (IVs). The inverse variance-weighted (IVW) method was used as the principal MR analysis to assess the causal relationship between gut microbiota and these tumors, with the goal of identifying microbial communities associated with gynecologic tumor development. An independent validation cohort was used for further validation. We conducted sensitivity analyses to ensure robustness of the findings. Lastly, we performed reverse MR analysis to assess the potential for reverse causation.
Results: Combining the results from the discovery and validation cohorts, we found that higher relative abundance of Lachnospiraceae is associated with lower risk of UF (OR: 0.882, 95% CI: 0.793-0.999, P = 0.982). Conversely, a higher incidence of OC is associated with a higher relative abundance of Lachnospiraceae (OR: 1.329, 95% CI: 1.019-1.732, P= 0.036). Sensitivity analyses confirmed the reliability of these results. Furthermore, the results of the reverse MR analysis showed no evidence of a reverse cause-and-effect relationship between UF, OC, and Lachnospiraceae.
Conclusion: In this study, a causal relationship between Lachnospiraceae and both UF and OC was established. This provides new insights into the role of gut microbiota in the mechanism of gynecological tumor development.
The Influence of Photobiomodulation in the CAM Assay – Establishing a CAM burn wound model
Authors: Firouz Bardia , Faihs Lorenz , Slezak Paul , Ghaffari-Tabrizi-Wizsy Nassim , Schicho Kurt , Winter Raimund , Kamolz Lars Peter , Dungel Peter 
Published: September 2023

Abstract
Burn wounds are a common challenge for medical professionals. Current burn wound models hold several limitations, including a lack of comparability due to the heterogeneity of wounds and differences in individual wound healing. Hence, there is a need for reproducible in vivo models. In this study, we established a new burn wound model using the chorioallantoic membrane assay (CAM) as a surrogate model for animal experiments. The new experimental setup was tested by investigating the effects on burn wound healing of the auspicious biophysical therapy photobiomodulation (PBM), which has been shown to positively influence wound healing through vascular proliferative effects and the increased secretion of chemotactic substances. The easily accessible burn wounds can be treated with various therapies. The model enables the analysis of ingrowing blood vessels (angiogenesis) and diameter and area of the wounds. The established model was used to test the effects of PBM on burn wound healing. PBM promoted angiogenesis in burn wounds on day 4 (p = .005). Furthermore, there was a not significant trend toward a higher number of vessels for day 6 (p = .065) in the irradiated group. Changes in diameter (p = .129) and the burn area (p = .131) were not significant. Our results suggest that CAM can be a suitable model for studying burn wounds. The novel experimental design enables reproducible and comparable studies on burn wound treatment.
Sport Nutrition Practice and Performance of Short Distance Runners: the Case of Oromia Athletics Clubs
Authors: Dano Gizaw Warji , Demena Tesfaye , Merga Lencho , Umeta Bekama , Kidane Tekalegn Fikadu , Denu Dawit Atomsa 
Published: September 2023

Abstract
The study was aimed to assess the impact of sport nutrition practice on performance of sprinters of Oromia selected athletics club. The athlete's diet affects his or her performance directly. Competitive athletes must eat a balanced diet containing all four food groups, and eating a variety of foods within each group is essential. However, no studies conducted on the impact of nutrition on Oromia short distance runners. A cross-sectional research design was employed.Out of eight (N=8) athletics clubs Oromia athletics club, five (n=5) of them were selected as target population namely; Adama, Nekemte, Asella, Dukam and Laga-Tafo Laga Dadhi athleticsclubs. The clubs were selected by using a simple random sampling technique. The total population of athletes in selected clubs was (N=175) and sampled athletes were 120 Adama (23), Nekemte, (24) Asella, (23) Dukam (26) and Laga-Tafo-Laga Dadhi (24) athletics) were selected using a stratified sampling technique. While coaches (N=5) were selected using census sampling techniques. Data collection instrument such as questionnaire, document analysis, interviews and observation were used. Analysis was performed using SPSS 25.0 (SPSS Inc., Chicago, IL) software. Frequency percentage and Simple regression was used quantitative data. Qualitative analysis was used to supplement the quantitative analysis. The result of this study shows that inadequate sprinters nutritional practice affects sprinters performance at p< 0.05. The finding of this study reveals that the majority of sprinters confirmed that sprinters did not get balanced sprinters diet due to this the sprinters performance was poor. As a recommendation, Oromia athletics club should plan for sport nutrition education and allocate enough budgets. Sprinters better extra meal apart from their clubs.
Membrane Dehumidification Technology for Removing Water Vapor from Exhaust Gas in Sludge Drying Process: Full-scale Application and Membrane Autopsy
Authors: Jeon Mi-Jin , Jeon Yong-Woo , Park Young-Kwon 
Published: September 2023

Abstract
Manufacturing solid fuels by drying sewage sludge is an effective method for increasing the production of renewable energy sources; however, the existing technology presents considerable economic challenges owing to high energy consumptions of the drying process. Here, an innovative sludge-drying process that combines microwave drying and membrane dehumidification technologies, using a gas-separation membrane, was developed and applied for the first time. Additionally, a membrane autopsy study was conducted on the dehumidification membranes. The 10 t/d system was continuously operated, and after the stabilization period, a highly efficient sludge drying process was observed; the consumed energy for drying was maintained at ≤ 650 kcal/kg water. Mean water vapor removal ratio in the membrane dehumidifier and dry air circulation rate was 82.2% and 85.2%, respectively. After 80 d of continuous operation, membrane autopsy was done to compare the performances of the contaminated and virgin membrane modules. We observed that long-term operation did not induce any significant change in membrane performance, except for slight organic contamination; this is a very meaningful result. Thus, we showed and verified that even under specific adverse conditions during the sludge-drying process, the combined membrane drying process was effective during long-term operation.
Genomic analysis of Plasmodium vivax identifies putative drivers of adaptation and connectivity across diverse districts in Ethiopia
Authors: Kebede Alebachew Messele , Sutanto Edwin , Trimarsanto Hidayat , Benavente Ernest Diez , Barnes Mariana , Pearson Richard , Siegel Sasha , Erko Berhanu , Assefa Ashenafi , Getachew Sisay , Aseffa Abraham , Petros Beyene , Lo Eugenia , Mohammed Rezika , Yilma Daniel , Rumaseb Angela , Nosten Francois , Noviyanti Rintis , Rayner Julian , Kwiatkowski Dominic , Price Ric , Golassa Lemu , Auburn Sarah 
Published: September 2023

Abstract
Ethiopia has the greatest burden of Plasmodium vivax in Africa, but little is known about the epidemiological landscape of parasites across the country. We analysed the genomic diversity of 137 P. vivax isolates collected nine Ethiopian districts from 2012-16. Signatures of selection were detected by cross-country comparisons with isolates from Thailand (n = 104) and Indonesia (n = 111), representing regions with low and high chloroquine resistance respectively. 26% (35/137) of Ethiopian infections were polyclonal, and 48.5% (17/35) of these comprised highly related clones (within-host identity-by-descent > 25%), indicating frequent co-transmission and superinfection. Parasite gene flow between districts could not be explained entirely by geographic distance, with economic and cultural factors hypothesised to have an impact on connectivity. Amplification of the duffy binding protein gene (pvdbp1) was prevalent across all districts (16%-75%). Cross-population haplotype homozygosity revealed positive selection in a region proximal to the putative chloroquine resistance transporter gene (pvcrt-o). An S25P variant in amino acid transporter 1 (pvaat1), whose homologue has recently been implicated in P. falciparum chloroquine resistance evolution, was prevalent in Ethiopia (96%) but not Thailand or Indonesia (35–53%). The genomic architecture in Ethiopia highlights circulating variants of potential public health concern in an endemic setting with evidence of stable transmission.
The anomalous Hall effects and Rashba-Edelstein magnetoresistance in the ferrimagnetic Mn1.84Co0.46V0.86Al film
Authors: Xu Xiaoguang , Dou Chunyue , Zhao Xiaoyi , Zhu Zhiqiang , Zhang Tanzhao , Li Chexin , Meng Kangkang , Wu Yong , Li Ang , Khovaylo V.V. , Jiang Yong 
Published: September 2023

Abstract
Ferrimagnets have attracted increasing attention in spintronics due to the possibility of easy manipulation by magnetic or electric fields. In this study, we report the anomalous Hall effect (AHE) and Rashba-Edelstein magnetoresistance (REMR) in the new ferrimagnetic Mn1.84Co0.46V0.86Al (MCVA) films. The anomalous Hall resistivity (ρxy) changes gradually from negative to positive values with increasing film thickness. By separating the contributions of AHE, it is demonstrated that the thickness dependence origins from the competition between the skew scattering contribution and the sum of the side jumping and intrinsic terms. Besides the intrinsic bulk effect of MCVA, the interface Rashba-Edelstein effect also obviously influences the transport property of MCVA-based devices due to interfacial spin-orbit coupling (SOC). As the magnetic field increasing, the magnetic moments of MCVA switch from collinear to non-collinear, resulting in an inversion of the REMR signal of MCVA/Al2O3 devices. The magnetic coupling state evolution in MCVA gives a pathway for signal inversion in REMR at interfaces without heavy metal layer, which provides valuable ideas for spintronic device design.
Structure-rheology Properties of Polyethylenes with Varying Macromolecular Architectures
Authors: Li Jixiang , Touil Ibtissam , de Alba Carlos Fernández , Boisson Fernande , Boyron Olivier , Narimissa Esmaeil , Lu Bo , Zhang Huagui , Maazouz Abderrahim , Lamnawar Khalid 
Published: September 2023

Abstract
It is proverbial that the rheological properties of low-density polyethylene (LDPE) and linear low-density polyethylene (LLDPE) are disparate because of their different molecular microstructures due to the unlike methods of polymerization. In this work, multiple characterizations including Size-Exclusion Chromatography (SEC) coupled with low-angle light scattering and viscosmeter, 13C Nuclear Magnetic Resonance, Crystallization Elution Fractionation (CEF) and Differential Scanning Calorimetry (DSC) were conducted to get detailed information of branching on different LDPEs and LLDPEs. It was found that, in our case, LDPEs possessed higher molecular weight and greater amounts of long-chain branching (LCB) in comparison with LLDPEs. The Chemical Composition Distribution (CCD) of each LLDPE sample depends strongly on the catalyst used. LLDPE produced by Z-N catalyst exhibited broad short-chain branching (SCB) distribution (less uniform composition distribution), whereas LLDPE obtained by metallocene catalyst showed more uniform microstructure. Unlikely, the two LDPEs displayed wider but unimodal distribution corresponding to the free-radical polymerization mechanism. Both linear and nonlinear rheological results were strongly influenced by the presence of LCB. LDPEs in this work exhibited higher zero shear-viscosity, higher values of storage modulus, longer relaxation times, and higher activation energy comparing to LLDPEs. The presence of LCB leads to more pronounced strain hardening behavior in the elongational flow which is neglected in LLDPE. The molecular structures of linear and branched PEs were consistent with the rheological properties.
Childhood Forced Feeding and Associated Factors Among Mothers or Caregivers Inaddis Ababa, Ethiopia
Authors: Ahmed Sindew Mahmud , Degif Abinet Besufikad , Baraki Semere Gebremariam , Getahun Genanew Kassie 
Published: September 2023

Abstract
Objective
To assess childhood forced feeding and associated factors among mothers or caregiver selected sub-cities, Addis Ababa, 2021.
Method
A community-based cross-sectional study was conducted from July to August 2021 in Addis Ababa, Ethiopia. A single population proportion formula was used. A total of 561 mothers or caregivers were selected using systematic sampling. The data was collected by a structured interview administered by a questioner, and the collected data was entered into Epi Data version 3.1 and exported to SPSS version 20 for further analysis. Binary and multiple logistic regression analyses were used to identify factors associated with the outcome variable. Texts, tables, and graphs were used to present the findings of the study.
Results
The prevalence of forced feeding was 74% (95% CI: 70.4–77.8%). Mothers or caregivers with less than $50 in monthly income (AOR = 0.292; 95% CI: 0.102–0.835), mothers with a perception that their child is underweight (AOR = 3.875; 95% CI: 1.519–9.886), mothers or caregivers concerned about being underweight (AOR = 8.872; 95% CI: 4.993–15.766), and mothers with three or more birth orders (AOR = 3.584; 95% CI: 1.4 to 1.4 to 3.676)
Conclusion
In comparison to previous studies, the magnitude of forced feeding by mothers or caregivers was high. Our data show that low-income households experience more force. Mothers who were anxious that their children were not eating enough had a higher likelihood of being forced to feed than mothers who were concerned that their children were eating too much. Forced feeding was more
An Analysis of the Psychological Well-being and Perspectives of Dental Students During the COVID-19 Pandemic: Lessons Learned
Authors: Alrawashdeh Mohammad , Alibrahim Anas , alhabashneh rola , Abualteen Tahani , Aljabary Leen 
Published: September 2023

Abstract
Objective: To evaluate the impact of COVID-19 pandemic on dental students’ education and psychological status.
Materials and Methods: In this cross-sectional study, an online survey was prepared and distributed to dental students and interns from two dental schools in Jordan. The psychological status of students was measured using the short-form version of the Depression, Anxiety, and Stress Scale (DASS).
Results: Of the 332 dental students surveyed, 230 (69.3%) were female. Approximately two-thirds of students expressed interest in receiving more guidance on COVID-19, while more than half (58%) were dissatisfied with the support offered by their schools during the pandemic. On a scale from 0-10, students reported a high potential influence of COVID-19 outbreak on dental practice in the short term (mean 8.9 ± 1.7), but a reduced impact in the long term (6.9 ± 2.3). Participants showed moderate levels of depression (mean 19.0 ± 12.2), anxiety (mean 10.4 ± 9.9), and stress (mean 19.6 ± 12.4), and these scores were significantly higher in females.
Conclusions: The COVID-19 pandemic had a substantial psychological impact on dental students and the education process. Dental and healthcare educational institutions need more preparation to provide the required psychological support, information, and training to their students.
Safety and immunogenicity and efficacy of the self-amplifying mRNA ARCT-154 COVID-19 vaccine
Authors: Hồ Nhân , Hughes Steven , Tạ Văn , Phan Lan , Đỗ Quyết , Nguyễn Thượng , Pham Anh , Đặng Mai , Nguyễn Lượng , Trinh Quang , Phạm Hùng , Chử Mến , Toan Nguyen Trong , Luong Quang , Lê Vy Thi , Nguyễn Thắng , Trần Lý-Thị-Lê , Lưu Anh , Nguyễn Anh , Nguyễn Nhung-Thị-Hồng , Vu Hai-Son , Edelman Jonathan , Parker Suezanne , Sullivan Brian , Sullivan Sean , Ruan Qian , Clemente Brenda , Luk Brian , Lindert Kelly , Berdieva Dina , Murphy Kat , Sekulovich Rose , Greener Benjamin , Smolenov Igor , Chivukula Padmanabh , Nguyễn Vân , Nguyen Xuan-Hung 
Published: September 2023

Abstract

Combination of waning immunity and lower effectiveness of approved COVID-19 vaccines against SARS-CoV-2 variants necessitates new vaccines. We evaluated the safety, immunogenicity and efficacy of a novel self-amplifying mRNA COVID-19 vaccine against the D614G variant, ARCT-154, in an integrated phase 1/2/3a/3b, randomized, observer-blind trial in Vietnamese adults. Two doses of ARCT-154 or placebo 28 days apart were well tolerated with mild to moderate transient adverse events. Four weeks after the second dose 94.1% (95% CI: 92.1–95.8) of vaccinees seroconverted for neutralizing antibodies, with a geometric mean-fold rise from baseline titers of 14.5 (95% CI: 13.6–15.5). Most cases of confirmed COVID-19 eligible for efficacy analysis were due to the Delta variant. Absolute efficacy of ARCT-154 was 56.6% (95% CI: 48.7–63.3) against any COVID-19, and 95.3% (80.5–98.9) against severe COVID-19. We show ARCT-154 vaccination is well tolerated, immunogenic and efficacious, particularly against severe COVID-19 disease and COVID-associated death.
Short-latency prepulse inhibition of the trigeminal blink reflex
Authors: Shingaki Megumi , Itoh Yasushi , Bayasgalan Borgil , Kida Tetsuo , Inui Koji 
Published: September 2023

Abstract
Prepulse inhibition (PPI) refers to the phenomenon in which a weak sensory input, that by itself does not reliably induce a startle reflex, suppresses the startle reflex induced by a subsequent strong sensory stimulus. A major challenge in studying PPI is the incomplete understanding of the startle reflex pathway as well as inhibition mechanisms. Here we focused on short-latency PPI of the trigeminal blink reflex R1 signal with an oligosynaptic reflex arc to clarify whether the PPI mechanism involves GABA-A equivalent inhibition. The reflex was elicited by electrical stimulation of the supraorbital nerve, and was recorded from the ipsilateral lower eyelid using an accelerometer. The stimulus intensity was 1.5 times the R1 threshold for the test stimulus and 0.9 times for the prepulse. The prepulse–test interval (PTI) was 5–150 ms. Results yielded two distinct inhibitions with different time scales; early inhibition peaking at 40-ms PTI or earlier, and a later one after 80-ms PTIs, which corresponds well to the common early and late components of inhibitory post synaptic potentials. There is clinical benefit to understanding the relative behavior of these two components in inhibitory function related diseases.