bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum Phase Synchronization via Electronic-Vibronic Energy Dissipation Sustains Long-lived Coherence in Photosynthetic Antennas
Authors: Weng Yuxiang , Zhu Ruidan , Li Wenjun , Zhen Zhanghe , Zou Jiading , Liao Guohong , Wang Jiayu , Wang Zhuan , Chen Hailong , Qin Song 
Published: September 2023

Abstract
Coherent energy transfer is a highly efficient energy transfer pathway in photosynthesis. Matching of long-lived quantum coherence to the time scale of energy transfer is a prerequisite1–3. In contrast to short-lived electronic coherence4, the presence of excitonic-vibronic coherence in photosynthetic systems5,6 can account for the observed long-lasting quantum coherence. However, uncovering the mechanism of such coherence within a biological environment is challenging because of the presence of noise typically encountered at room temperature. This paper presents conclusive evidence of the existence of long-lasting electronic vibronic coherence in the allophycocyanin trimer, in which pigment pairs behave as excitonic dimers after photo-excitation. Employing ultrafast two-dimensional electronic spectroscopy, our study demonstrates an extension of the electronic-vibronic coherence time within the trimer compared with the isolated pigments. The prolonged quantum coherences were identified as arising from the quantum phase synchronization of the resonant vibrational collective modes for the pigment pair. The anti-symmetric resonant collective modes undergo fast energy dissipation when coupled to the delocalized electronic states of fast dephasing, while the decoupled symmetric resonant collective modes survive, exhibiting significantly lowered energy dissipation and supporting long-lasting quantum coherences. The presence of the quantum phase synchronization was confirmed by two experimental indicators consistent with the expectation. This paper provides empirical evidence revealing how biological systems effectively employ a quantum synchronization strategy to uphold persistent coherences, and our findings pave the way for protecting coherences against the noisy environment in quantum biology7.
The feasibility of physical activity interventions for older adults living with and beyond carcinomas: a systematic review and meta-analysis
Authors: Dulai-Piper Anne E 
Published: September 2023

Abstract
Background
Older adults are increasingly being diagnosed with and surviving cancers, which can profoundly impact quality of life (QoL). Evidence suggests physical activity interventions can help manage the side effects of cancer and its treatment, and therefore improve QoL. However, older adults are often poorly represented within physical activity and cancer-related research, being excluded because of secondary cancers, comorbidities, and frailty. Therefore, the feasibility of such interventions still requires further investigation. The aim of this systematic review was to investigate the feasibility of physical activity interventions specifically designed for older adults living with and beyond carcinoma cancers.
Methods
This systematic review included feasibility and pilot studies investigating physical activity interventions for older adults (aged ≥ 65 years) living with or beyond any carcinoma, and at any stage of cancer and treatment. Feasibility outcomes were categorised under four metrics (process, resource, management, scientific) and Synthesised Without Meta-analysis according to published guidelines (SWiM). A meta-analysis was performed on four studies with physical activity outcome. The reporting quality of studies was reviewed using the consolidated standards of reporting trials extension for randomised pilot and feasibility studies.
Results
This current review included 19 studies and 571 participants and revealed that physical activity interventions are feasible for older adults living with or beyond carcinomas, based on adherence, participant-reported acceptability, retention, and safety. It was, however, identified that recruitment was a challenge, with a median of 73% (range 11–100%) eligible for recruitment whilst a median of 58% (range 3-100%) were recruited. It was further found that several feasibility outcomes had limited to no reporting (e.g., intervention fidelity), especially concerning resource and management metrics. Finally, only 8 studies included pre-specified criteria of success which is a key element in assessing if a study was feasible or not based on the criteria set.
Conclusions
Physical activity interventions are feasible for older adults living with or beyond carcinoma cancers. However, the reporting of feasibility outcomes could be improved to inform future research methodologies, and ultimately improve certainty in study feasibility.
Registration: This current systematic review was pre-registered on PROSPERO (CRD42022343724). The full protocol is on the open science framework https://osf.io/qpagz/.
The Intersection of Gambling with Smoking and Alcohol use in Great Britain: A Cross-Sectional Survey in October 2022
Authors: Kock Loren , Cox Sharon , Roberts Amanda , Sharman Steve , Buss Vera , Brown Jamie 
Published: September 2023

Abstract

Objectives
Gambling is often associated with cigarette smoking and alcohol consumption. This study aimed to explore the intersection of gambling across all risk levels harm with smoking and alcohol use among adults in Great Britain.
Design:
A nationally representative cross-sectional survey in October 2022.
Setting:
Great Britain.
Participants:
A weighted total of 2,398 adults (18 + years).
Outcome measures:
We examined the prevalence of gambling in the past year and, among those reporting gambling, assessed the associations between any risk of harm from gambling (scores of > 0 on the problem gambling severity index) and cigarette smoking and higher risk alcohol use. We also explored the average weekly expenditure on gambling, smoking and alcohol use among those categorised at any-risk of harm from gambling.
Results
Overall, 43.6% (95% CI 41.2–45.9) of adults gambled in the past year. Among those who gambled in the past year 7.3% (5.3–9.3) were classified at any-risk of harm from gambling, 16.0% 13.2–18.8) were currently smoking, and 40.8% (37.2–44.4) were drinking at increasing and higher risk levels. There were no apparent associations between any risk of harm from gambling and current cigarette smoking (ORadj = 0.80, 95% CI 0.35–1.66) or drinking at increasing and higher risk levels (ORadj = 0.94, 0.52–1.69), respectively. Analyses using Bayes factors indicated that these data were insensitive to distinguish no effect from a range of associations (OR = 0.5–1.9). The mean weekly spend on gambling was £7.69 (95% CI 5.17–10.21) overall, and £45.68 (12.07–79.29) among those at any risk of harm from gambling.
Conclusions
Pilot data in a population-level survey on smoking and alcohol use yielded estimates of gambling participation and at-risk gambling that are similar to other population-level surveys. Further data are needed to elucidate the intersections more reliably between gambling, smoking and alcohol use, and inform population-level approaches to reduce harms conferred by these behaviors.
Exploring biomarkers of intestinal ischemia reperfusion injury based on bioinformatics
Authors: chen wendong , Xu Wenping , Ma Li , Bi Chun , Yang Meixu , Yang Wei 
Published: September 2023

Abstract
Background: Intestinal ischemia reperfusion injury (IIRI) is relevant to crucial clinical manifestations. Hence, it was vital to screen the important biomarkers for the diagnosis and treatment of IIRI.
Methods: The transcript sequence data was yielded to screen out differentially expressed genes (DEGs) in IIRI. WGCNA was conducted to select key module genes related to IIRI vs normal groups. Venn Diagram was utilized to identify candidate genes. Further, PPI network of candidate genes was established to show the interaction relationship. LASSO and SVM-RFE analysis were implemented to screen biomarker of IRI. We finally performed immune infiltration and functional enrichment analysis based on biomarkers. Finally, the vital biomarkers ofin IIRI were verified by quantitative PCRand immunohistochemical.
Results: We identified 2919 DEGs and 1040 key module genes. Then, 483 candidate genes were obtained via venn diagram. Subsequently, 5 biomarkers (Ccl7, Cd14, Cxcl1, Hmox1 and Nfkbia) were identified via machine learning. Moreover, we found that these biomarkers was mainly enriched in the ‘reactome activation of NF -kappa-B in B cells’ pathway. We also found that 5 biomarkers were significantly positively correlated with actived DC, M2 Macrophage and Th2 cells, whereas all biomarkers was negatively correlated with immature DC, gammadelta T cells. For expression validation of the biomarkers, we observed higher expression of Ccl7,Cd14, Cxcl1, Hmox1 and Nfkbia in IIRI group in the sequencing data. we validated the expression in mouse tissue by RT-qPCR and immunohistochemical, which all tested and verified the conclusion of sequencing data analysis.
Conclusion: Overall, we obtained 5 biomarkers (Ccl7, Cd14, Cxcl1, Hmox1 and Nfkbia), which laid a theoretical foundation for the mechanism and clinical research of IIRI.
Sources of Pathogenic Microorganisms and Their Fate during Land Application of Wastes
Authors: Gerba Charles P. , Smith James E. 
Published: September 2023

ABSTRACTThe hazards associated with pathogens in land‐applied animal and human wastes have long been recognized. Management of these risks requires an understanding of sources, concentrations, and removal by processes that may be used to treat the wastes; survival in the environment; and exposure to sensitive populations. The major sources are animal feeding operations, municipal wastewater treatment plant effluents, biosolids, and on‐site treatment systems. More than 150 known enteric pathogens may be present in the untreated wastes, and one new enteric pathogen has been discovered every year over the past decade. There has been increasing demand that risks associated with the land treatment and application be better defined. For risks to be quantified, more data are needed on the concentrations of pathogens in wastes, the effectiveness of treatment processes, standardization of detection methodology, and better quantification of exposure.
Manure Management Effects on Grass Production, Nutritive Content, and Soil Nitrogen for a Grass Silage–Based Dairy Farm
Authors: VanWieringen Lynn M. , Harrison Joe H. , Nennich Tamilee , Davidson Debra L. , Morgan Lloyd , Chen Shulin , Bueler Mike , Hoisington Floyd 
Published: September 2023

ABSTRACTLegislation in the United States has recently focused on improving water quality by establishing management practices that limit the quantities of nutrients entering the water supply. Timely application and quantification of the amount of manure applied throughout the grass‐growing season can reduce the loss of nutrients into ground or surface water while improving the quality and quantity of grass harvested. During the 2001 and 2002 growing seasons, we measured the effects of different manure application rates on grass yields, grass nutritive value, and soil chemistry on a dairy farm. On‐farm estimates of manure N were combined with yield estimates and forage quality measures to evaluate the effects of varying levels of manure application. Yield estimates, N content of grass, and the amount of N in soil and manure were monitored at each cutting for plots amended at different manure application rates. There are three major outcomes of this evaluation: (i) new grass seedings were at higher risk of elevated levels of nitrate N in forage; (ii) increased forage nitrate N at harvest was associated with malfermented silage and increased levels of ammonia N, which resulted in less efficient use of metabolizable protein for milk production; and (iii) increased understanding of N cycling between manure, soil, and plant provided an opportunity to reduce purchased fertilizer.
MATTHEW ARNOLD’S ‘THE FORSAKEN MERMAN’ AND ‘THE NECKAN’AS REFLECTIONS OF VICTORIAN FEARS
Authors: Tica Dijana D. 
Published: September 2023

Based on folk tales of Northern European nations, Arnold’s poems ‘The Forsaken Merman’ (1849) and ‘The Neckan’ (1853), both tell a story of human women who marry sea creatures, mermen, and replace their home on the land with the mermen’s underwater world. By crossing the boundaries between their worlds, they cause numerous problems, most significantly the tension resulting from their different religious beliefs. In ‘The Forsaken Merman’, Margaret, the merman’s wife, fearing that her soul will be damned because of her marriage to a pagan, decides to rejoin the human world on the most important Christian holiday, Easter. In ‘The Neckan’, in order to comfort his wife, the Neckan goes to the human world to find a priest who would be willing to baptise him, but he is rejected because he is a ‘monster’ who cannot be saved.
The paper will examine the way in which Arnold’s poems reflect the fears of the Victorian era as well as his own anxieties. This will be accomplished by comparing the two opposite worlds of the poems – the human world of everyday activities, rules, laws, and expectations; and the mermen’s home, the mysterious, colourful, and peaceful world of sea-beasts. In addition, the paper will analyse the reversal of traditional gender roles and re-examine literary, cultural, and social stereotypes. The paper will also attempt to find a connection between the main topics of these poems and Arnold’s life and career of a poet and literary critic.
Development of water resources protection planning and environmental design in urban water conservancy landscape based on ecological concept
Authors: Huang Hua 
Published: September 2023

Abstract

With the development of society, water resources are gradually scarce and water pollution is becoming increasingly serious, which would seriously restrict the development of the urban economy. In response to the current problems of water scarcity and severe water pollution, this article will study the key points of urban environmental design development based on ecological concepts. This article will also use ecological concepts to divide water function zones based on different pollution-carrying capacities in different regions, which can be mainly divided into two levels. In the experimental analysis section, the Xiongan New Area will be analyzed. This article randomly selected three regions in the Xiongan New Area and studied the utilization rate of various types of water in these regions. The pollution capacity and main water resources of each region in the functional area were planned and designed. Through experiments, it can be found that based on ecological concepts, it is beneficial to improve the pollutant-carrying capacity of each functional area and reduce the total amount of ammonia nitrogen.
The Power of Molecular Dynamics Simulations and Their Applications to
Discover Cysteine Protease Inhibitors
Authors: dos Santos Nascimento Igor José , Santana Gomes Joilly Nilce , de Oliveira Viana Jéssika , de Medeiros e Silva Yvnni Maria Sales , Barbosa Euzébio Guimarães , de Moura Ricardo Olimpio 
Published: September 2023

Abstract:
A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases
or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved.
CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can
be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papainlike
endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues
of His, Glu/Asp, Gln, Cys (CE). The catalytic mechanism of CPs is the essential cysteine residue present
in the active site. These mechanisms are often studied through computational methods that provide
new information about the catalytic mechanism and identify inhibitors. The role of computational
methods during drug design and development stages is increasing. Methods in Computer-Aided Drug
Design (CADD) accelerate the discovery process, increase the chances of selecting more promising
molecules for experimental studies, and can identify critical mechanisms involved in the pathophysiology
and molecular pathways of action. Molecular dynamics (MD) simulations are essential in any
drug discovery program due to their high capacity for simulating a physiological environment capable
of unveiling significant inhibition mechanisms of new compounds against target proteins, especially
CPs. Here, a brief approach will be shown on MD simulations and how the studies were applied to
identify inhibitors or critical information against cysteine protease from several microorganisms, such
as Trypanosoma cruzi (cruzain), Trypanosoma brucei (rhodesain), Plasmodium spp. (falcipain), and
SARS-CoV-2 (Mpro). We hope the readers will gain new insights and use our study as a guide for potential
compound identifications using MD simulations.
Conducting 2D and 3D QSAR Analyses and Molecular Docking Studies of
Analogues of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol with the
Aim of Identifying Promising Drug Candidates for Targeting Glioblastoma
Authors: Pan Meichen , Cheng Lingxue , Wang Yiguo , Lyu Chunyi , Hou Chao , Zhang Qiming 
Published: September 2023

Background:
2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl) ethan-1-ol analogues represent novel
glutaminase 1 inhibitors. Their exemplary antineoplastic efficacy underscores their prospective utility in
glioblastoma chemotherapy.

Objectives:
This study aimed to elucidate 2D and 3D-QSAR models that authenticate the antineoplastic
efficacy of ethan-1-ol analogues and delineate optimal structural configurations conducive to new pharmaceutical
design.

Methods:
The Heuristic Method (HM) was employed for the development of a 2D-linear QSAR paradigm,
whilst the Gene Expression Programming (GEP) algorithm was employed for a 2D-nonlinear
QSAR paradigm. Concurrently, the CoMSIA methodology was deployed to scrutinize the nexus between
pharmaceutical structure and potency. An ensemble of 200 nascent anti-glioma ethan-1-ol compounds
was conceptualized, and their potency levels were prognosticated via chemical descriptors and molecular
field delineations. Pharmaceuticals epitomizing peak potency were earmarked for molecular docking
validation.

Results:
The empirical modeling exhibited pronounced superiority with the 3D paradigm, succeeded by
the GEP nonlinear paradigm and culminated with the HM linear model. The 3D paradigm was characterized
by a robust Q2 (0.533), R2 (0.921), and F-values (132.338) complemented by a minimal SEE
(0.110). The molecular descriptor MNO coupled with the hydrogen bond donor field facilitated novel
pharmaceutical conceptualizations, leading to the identification of the quintessential active molecule,
24J.138, lauded for its superlative antineoplastic attributes and docking proficiency.

Conclusion:
The orchestration of bidimensional and tridimensional paradigms, synergized by innovative
amalgamation of contour maps and molecular descriptors, provides novel insights and methodologies for
the synthesis of glioblastoma chemotherapeutic agents.
Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle-derived miR-27b-
3p activates the Wnt/Β-catenin Pathway by Targeting SMAD4 and Aggravates
Hepatic Ischemia-reperfusion Injury
Authors: Li Hongnan , Lin Weidong , Li Yunlei , Zhang Jiayang , Liu Runsheng , Qu Minghai , Wang Ruihua , Kang Xiaomin , Xing Xuekun 
Published: September 2023

Background:
To investigate the roles of extracellular vesicles (EVs) secreted from bone marrow
mesenchymal stem cells (BMSCs) and miR-27 (highly expressed in BMSC EVs) in hepatic ischemia‒
reperfusion injury (HIRI).

Approaches and Results:
We constructed a HIRI mouse model and pretreated it with an injection of
agomir-miR-27-3p, agomir-NC, BMSC-EVs or control normal PBS into the abdominal cavity. Compared
with the HIRI group, HIRI mice preinjected with BMSC-EVs had significantly decreased alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) levels and alleviated liver necrosis (P<0.05).
However, compared with HIRI+NC mice, HIRI+miR-27b mice had significantly increased ALT and AST
levels, aggravated liver necrosis, and increased apoptosis-related protein expression (P<0.05). The proliferation
and apoptosis of AML-12 cells transfected with miR-27 were significantly higher than the proliferation
and apoptosis of AML-12 cells in the mimic NC group (P<0.01) after hypoxia induction. SMAD4
was proven to be a miR-27 target gene. Furthermore, compared to HIRI+NC mice, HIRI+miR-27 mice
displayed extremely reduced SMAD4 expression and increased levels of wnt1, β-catenin, c-Myc, and
Cyclin D1.

Conclusion:
Our findings reveal the role and mechanism of miR-27 in HIRI and provide novel insights
for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-
27 might demonstrate better protection against HIRI.
A Study of the Characteristics of Regional Building Construction Process
Authors: Yoshida Satoshi 
Published: September 2023

Introduction:
In recent years, as in other fields, the architectural field has become increasingly globalized and internationalized. In this context, it is likely essential for each organization worldwide to understand how to leverage their respective strengths in internationalized projects. However, aspects of the characteristics related to how architecture is built in different regions are not fully understood.

Objective:
This study aims to develop a methodology for understanding the characteristics of architectural styles in different regions. In particular, this paper will focus on the process of building architecture and develop a methodology to understand the international differences at this point.

Methodology:
This study uses the “Architecture Concept” as the methodology. This methodology focuses on the interdependence among the components of an artifact. In this manuscript, the “building process” was considered one of the objects of this methodology. Although all construction projects take place under different conditions, it is possible to understand the tendency of design information of process design with this methodology.

Results:
This study selects regions where the building industry has reached technological maturity and compares building processes. Specifically, the UK in Europe and Japan in Asia will be compared. As a result, it is understood that the architectural process in the UK is more modular than the process in Japan. This analysis reveals that it is possible to understand the process in an “architectural” way.
TINJAUAN PENGEMBANGAN MATERIAL BERBASIS BARIUM TITANAT, KOMPOSIT PVDF/BATIO3 DAN BATIO3/HAP UNTUK APLIKASI ELECTROSTATIC DIELECTRIC ENERGY STORAGE CAPACITOR
Authors: Adnan Septian Rahmat , Kurniawan Budhy , Soegijono Bambang 
Published: September 2023

Barium titanate (BaTiO3) is ceramic material that is widely used in various applications..Electrostatic dielectric energy storage capacitor is one of the application of Barium titanate (BaTiO3) material. Composite materials based on barium titanate (BaTiO3) such as Polyvinylidene fluoride (PVDF)/BaTiO3 and BaTiO3/HAp Hydroxyapatite have been developed to improve the electrical properties of the materials. Many research have been reported hat barium titanate in nano phase has a maximum dielectric constant 5000 with particle size range of 30-50 nm. The addition of BaTiO3 composition as a filler to PVDF/BaTiO3 composite caused increasing of dielectric constant compared to the dielectric constant properties of the PVDF. Similar results also found on BaTiO3/HAp composite. From this review, it was also found that the composite of these three materials is a candidate for future material to improve the electrical properties of PVDF which have been applied to electrostatic dielectric energy storage capacitor applications.