bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study on inventory control strategies of fresh food supply chain considering advertising delay effect
Authors: Jiang Yongchang , Zhu Hejie , Bai E. 
Published: September 2023

PurposeThe existence of the advertising delay effect and its impact on supply chain operations have been demonstrated in the current study. Therefore, this study develops a timely inventory control strategy for the fresh produce supply chain to address the advertising delay effect in the fresh produce supply chain.Design/methodology/approachThis study proposes a game model based on the Nerlove-Arrow time delay differential equation and Pontryagin's maximum principle. Through comparative analyses of the optimal equilibrium strategies, the authors compare the optimal equilibrium strategies, product goodwill and optimal inventory trajectories for suppliers and retailers under secondary replenishment decisions and decentralized decisions.FindingsThe authors find that (1) Only when the sales cycle meets certain conditions can the overall profit of the supply chain under the secondary replenishment decision be greater than that under the decentralized decision. As the price markup coefficient increases, the total profit of the supply chain first increases and then decreases. (2) With the increase in the delay time, the replenishment quantity during the initial period gradually decreases. After the delay time elapses, the inventory depletion rate under secondary replenishment decisions is faster than that under decentralized decision-making. (3) Although there is a continuously increasing maximum value of product goodwill with the increase in delay time, it becomes difficult to achieve this value for longer delays.Practical implicationsThe authors’ findings provide a theoretical basis for supply chain members of fresh agricultural products to select replenishment and inventory control strategies when adopting different levels of delay in advertising marketing.Originality/valueFirstly, this paper explains the impact of advertising delay effect on fresh produce supply chain from a dynamic perspective, and secondly, it provides guidance on advertising formulation and inventory replenishment for fresh produce retailers under the influence of advertising delay effect.
Consumer behaviour towards milk and dairy yoghurt products carrying nutrition and health claims: a qualitative study
Authors: Collins Nuala , Lalor Fiona 
Published: September 2023

Purpose
Milk and yoghurt provide essential sources of nutrition throughout the life cycle in the Irish diet. Health claims on dairy product labels were popular in the 1980s, and since the introduction of the nutrition and health claims (NHC) Regulation (EC) No 1924/2006 in 2007, many new regulated claims have been used to communicate product benefits. Meanwhile, COVID-19 and the Farm to Fork strategy have heightened consumer awareness of health issues. All of these factors have contributed to a change in our food environment and interest in health. In addition, the European Commission is working to introduce a legislative proposal on nutrient profiles (NP) to restrict the use of NHC on foods that are high in salt, fat or sugar. This qualitative study aims to research knowledge on adults’ attitudes, perceptions and behaviour towards NHC on dairy products.

Design/methodology/approach
The study used a thematic analysis using transcripts from a series of discussion groups, attended by adults (n = 24). The participants also completed an introductory questionnaire.

Findings
The study noted positive attitudes towards dairy protein. This attitude was common across age, gender or life stage. There were misperceptions regarding yoghurt composition and health benefits. There were negative perceptions of low-fat nutrition claims on yoghurt, which led to a preference for full-fat dairy products. This requires further insight and research.

Research limitations/implications
Participants from a wider socio-demographic group could have broadened the research limits of this project.

Originality/value
These findings will interest policymakers, regulators, dieticians and the food industry.
The uptake of digital twins in delivering infrastructure sector projects
Authors: Sohal Kavita , Renukappa Suresh , Suresh Subashini , Georgakis Panagiotis , Stride Nici 
Published: September 2023

PurposeThe anticipated strong growth of the infrastructure industry over the coming decades will require more modern, digital approaches to create data-centric infrastructure that allows infrastructure to be monitored and managed throughout its lifecycle. Digital twins (DTs) are currently at an early stage in terms of their implementation on infrastructure projects across the United Kingdom (UK). The purpose of this paper is to evaluate the current uptake of DTs in delivering infrastructure sector projects and how DTs can help contribute towards strengthening the industry.Design/methodology/approachA systematic literature review approach has been conducted with the research questions derived from the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) article screening tool. In addition to this, inclusion and exclusion criteria have been used to screen irrelevant information and help streamline research documents. Following a screening of relevant information, 36 pieces of literature were reviewed in order to identify the key drivers, barriers, enabling technologies and use cases.FindingsDTs have the potential to transform asset design, production and maintenance. However, to further advance the digital innovation in the UK infrastructure sector, further study is necessary. An emerging technology must be considered on a broader scale than just its technical aspects, particularly when it comes to DTs. With enabling technologies such as the Internet of Things (IoT), sensors and artificial intelligence (AI), the uptake of DTs appears promising. While current literature indicates that DTs offer clear benefits in the infrastructure sector, the uptake is low and hindered by both technical and non-technical challenges.Originality/valueThis paper provides a rich insight into the understanding and awareness of the DTs in delivering infrastructure sector projects and how the infrastructure sector has evolved in order to develop new ways of designing, constructing, operating and monitoring infrastructure assets. This study contributes towards informing leaders in the sector of the current uptake of DTs within the UK's infrastructure sector as well as how DTs can contribute towards strengthening the industry.
Caught Between a Well‐Intentioned State and a Hostile Federal System: Local Implementation of Inclusive Immigrant Policies
Authors: YOUNG MARIA‐ELENA DE TRINIDAD , TAFOLLA SHARON , PEREZ‐LUA FABIOLA M. 
Published: September 2023

Policy Points
Inclusive state immigrant policies that expand rights and resources for immigrants may improve population health, but little is known about their local‐level implementation.
Local actors that have anti‐immigrant attitudes can hinder the implementation of state policies, whereas the persistent influence of anti‐immigrant federal policies reinforces barriers to accessing health and other resources granted by state policies.
Local actors that serve immigrants and support state policy implementation lack the resources to counter anti‐immigrant climates and federal policy threats.
ContextIn the United States, inclusive state‐level policies can advance immigrant health and health care access by extending noncitizens’ access to public benefits, workplace rights, and protections from immigration enforcement. Although state policies carry promise as structural population health interventions, there has been little examination of their implementation at the local level. Local jurisdictions play multiple roles in state policy implementation and possess distinct immigration climates. Examining the local implementation of state immigrant policy can address challenges and opportunities to ensure the health benefits of inclusive policies are realized equitably across states’ regions.MethodsTo examine the local implementation of state immigrant policies, we selected a purposive sample of California counties with large immigrant populations and distinct social and political dynamics and conducted and analyzed in‐depth interviews with 20 community‐based organizations that provided health, safety net, and other services.FindingsWe found that there were tensions between the inclusionary goals of state immigrant policies and local anti‐immigrant climates and federal policy changes. First, there were tensions between state policy goals and resistance from local law enforcement agencies and policymakers (e.g., Board of Supervisors). Second, because of the ongoing threats from federal immigration policies, there was a mismatch between the services and resources provided by state policies and local community needs. Finally, organizations that served immigrants were responsible for contributing to policy implementation but lacked resources to meet community needs while countering local resistance and federal policy threats.ConclusionsThis study contributes knowledge regarding the challenges that emerge after state immigrant policies are enacted. The tensions among state immigrant policies, local immigration climates, and federal policy changes indicate that state immigrant policies are not implemented equally across state communities, resulting in challenges and limited benefits from policies for many immigrant communities.
Xenobiotic metabolites modify immune responses of the cervicovaginal epithelium: potential mechanisms underlying barrier disruption
Authors: Gerson Kristin D. , Loder Aaron , Landau Zachary , Anton Lauren 
Published: September 2023

AbstractObjectiveXenobiotic metabolites are exogenous biochemicals that can adversely impact reproductive health. We previously identified xenobiotics in cervicovaginal fluid during pregnancy in association with short cervix. In other organ systems, xenobiotics can modify epithelial barrier function. We hypothesise that xenobiotics dysregulate epithelial cell and macrophage immune responses as a mechanism to disrupt the cervicovaginal barrier.DesignIn vitro cell culture system.SettingLaboratory within academic institution.SampleVaginal, ectocervical and endocervical epithelial cell lines and primary macrophages.MethodsCells were treated with diethanolamine (2.5 mM), ethyl glucoside (5 mM) or tartrate (2.5 mM) for 24 h.Main outcome measuresCytokines and matrix metalloproteinases were measured in cell supernatants (n = 3 per condition). One‐way analysis of variance (ANOVA) with Dunnett's test for multiple comparisons was performed.ResultsDiethanolamine induces inflammatory cytokines, whereas ethyl glucoside and tartrate generally exert anti‐inflammatory effects across all cells. Diethanolamine increases interleukin 6 (IL‐6), IL‐8, interferon γ‐induced protein 10 kDa (IP‐10), growth‐regulated oncogene (GRO), fractalkine, matrix metalloproteinase 1 (MMP‐1), MMP‐9 and MMP‐10 (p < 0.05 for all), factors involved in acute inflammation and recruitment of monocytes, neutrophils and lymphocytes. Ethyl glucoside and tartrate decrease multiple cytokines, including RANTES and MCP‐1 (p < 0.05 for all), which serve as chemotactic factors. Vaginal cells exhibit heightened inflammatory tone compared with cervical cells and macrophages, with a greater number of differentially expressed analytes after xenobiotic exposure.ConclusionsXenobiotic metabolites present in the cervicovaginal space during pregnancy modify immune responses, unveiling potential pathways through which environmental exposures may contribute to the pathogenesis of cervical remodelling preceding preterm birth. Future work identifying xenobiotic sources and routes of exposure offers the potential to modify environmental risks to improve pregnancy outcomes.
Petrogenesis and Tectonic Implications of the Early Triassic Nianzi Adakitic Granite Unit in the Yanshan Fold and Thrust Belt: New Constraints from U‐Pb Geochronology and Sr‐Nd‐Hf Isotopes
Authors: ZHANG Huijun , WU Chu , HE Fubing , WANG Biren , CUI Yubin , LIU Zhenghua , YOU Shina , DONG Jing 
Published: September 2023

AbstractThe Nianzi granite unit, which includes the Nianzi, Xiaolianghou and Xiawopu granitic intrusions, is a significant component of the northern part of the North China Craton (NCC) and is situated in the Yanshan fold and thrust belt (YFTB). However, there is still debate regarding the tectonic evolutionary history of the YFTB during the late Permian to Triassic period, specifically regarding the timing of subduction and collision between the NCC and the Paleo‐Asian Ocean. The Nianzi granite unit exhibits unique petrological, geochronological and geochemical signatures that shed light on the tectonic evolutionary history of the YFTB. This study presents detailed petrology, whole‐rock geochemistry, together with Sr‐Nd isotopic, zircon U‐Pb dating and Lu‐Hf isotopic data of the granites within the Nianzi granite unit. Our findings demonstrate that the granites primarily consist of subhedral K‐feldspar, plagioclase, quartz, minor biotite and hornblende, with accessory titanite, apatite, magnetite and zircon. Zircon U‐Pb dating indicates that the Xiaolianghou granite was emplaced at 247.5 ± 0.62 Ma. Additionally, the adakitic characteristics of the Nianzi, Xiawopu and Xiaolianghou granitic intrusions, such as high Sr and Ba contents and high ratios of Sr/Y and (La/Yb)N, combined with negative Sr‐Nd and Lu‐Hf isotopes (87Sr/86Sr)i = 0.705681–0.7057433, εNd(t) = –21.98 to –20.97, zircon εHf(t) = –20.26 to –9.92), as well as the I‐type granite features of high SiO2, Na2O and K2O/Na2O ratios, enriched Rb, K, Sr and Ba, along with depleted Th, U, Nb, Ta, P and Ti, suggest that the Nianzi granitic unit was mainly derived from the partial melting of a thickened lower crust containing hydrous, calc‐alkaline to high‐K calc‐alkaline, mafic to intermediate metamorphic rocks. In light of these parameters, we further integrate our data with previous studies and conclude that the Nianzi granitic unit was generated in a post‐collisional extensional environment during the Early Triassic.
Effectiveness and safety of rituximab in special types of rheumatoid arthritis
Authors: Takanashi Satoshi , Kondo Yasushi , Saito Shuntaro , Kikuchi Jun , Hanaoka Hironari , Takeuchi Tsutomu , Kaneko Yuko 
Published: September 2023

AbstractObjectivesTo elucidate the efficacy and safety of rituximab in special types of rheumatoid arthritis.MethodsWe retrospectively reviewed all patients with rheumatoid arthritis with lymphoproliferative disorder or vasculitis treated with rituximab between April 2010 and June 2022 at Keio University Hospital. We assessed the effectiveness of rituximab using the Disease Activity Score for 28 joints‐erythrocyte sedimentation rate (DAS28‐ESR), Clinical Disease Activity Index (CDAI), and safety of rituximab during the disease course. We also assessed the glucocorticoid‐sparing effects of rituximab.ResultsWe included eight patients with a history of lymphoproliferative disorder and five patients with rheumatoid vasculitis. They were treated with rituximab without high‐dose glucocorticoid. The mean DAS28‐ESR and CDAI scores significantly improved 12 months after rituximab administration (DAS28‐ESR, 4.7 vs. 2.7, p < .001; CDAI, 16.0 vs. 5.1, p = .006, respectively), and the dose of prednisolone was reduced from a mean of 7.4 mg/day to 4.0 mg/day at 12 months (p = .05) and 3.2 mg/day at the last visit (p = .04). During the mean follow‐up period of 52 months, we recorded one recurrence of lymphoproliferative disorder (not B‐cell type) in patients with a history of lymphoproliferative disorder and remarkable improvement of skin ulcers in patients with vasculitis.ConclusionB‐cell depletion by rituximab may be a useful treatment option for patients with lymphoproliferative disorder and rheumatoid vasculitis.
High‐intensity drinking and hours spent drinking
Authors: Patrick Megan E. , Parks Michael J. , Peterson Sarah J. 
Published: September 2023

AbstractBackgroundHigh‐intensity drinking (HID) is associated with negative consequences, but it remains unclear whether a time qualifier (i.e., time spent drinking) is needed to identify individuals at highest risk. To improve the measurement and conceptualization of HID, we examined the utility of adding a time qualifier to define what constitutes an occasion of HID using repeated daily surveys in a sample of young adults.MethodsParticipants were selected from a nationally representative sample of 12th‐grade students in the United States who participated in the Monitoring the Future (MTF) study in Spring 2018. In 2019 and 2020, young adults (at modal ages 19–20) responded to annual and daily (14 consecutive days per year) online surveys about their alcohol use.ResultsWhen we compared moderate drinking days (less than 4/5 drinks for women/men), binge drinking days (4–7/5–9 drinks), and HID days (8+/10+ drinks), HID days had the longest duration of drinking (5.2 h), highest peak estimated blood alcohol concentration (eBAC, 0.30%), and greatest drinking pace (2.58 drinks/h). HID was associated with a greater number of negative consequences than either moderate or binge drinking; adjusting for time spent drinking did not impact this interpretation. HID was reported on 10.9% of days; when defined as 8/10+ drinks in 4 h or 2 h, HID was reported on 4.8% and 1.0% of days, respectively. Nearly all differences in eBAC and negative consequences persisted across drinking intensity despite the introduction of time constraints.ConclusionsHID days were characterized by both a longer time spent drinking and a more rapid pace of drinking. Adding a time qualifier to the definition of HID would restrict variability by only describing the minority of days and does not improve the distinctions among levels of risk.
Accounting firm office size and tax aggressiveness
Authors: Fu Yi (Dale) , Lim Youngdeok , Carson Elizabeth 
Published: September 2023

AbstractThis paper empirically investigates the association between the size of accounting firm offices and corporate tax aggressiveness. We find that clients audited by large offices have lower levels of corporate tax aggressiveness. We also find that such a negative relation is less pronounced when an accounting firm office provides tax services or when the office possesses tax‐specific industry expertise, and it is more pronounced when a client is financially important. The study contributes to the literature by documenting the role of accounting firm offices in influencing tax aggressiveness.
Searching for new signals for susceptibility to umbilical hernia through genome‐wide association analysis in three pig breeds
Authors: Yang Hui , Wang Lei , Yin Lilin , Tang Zhenshuang , Wang Zhangxu , Liu Xiangdong , Xiang Tao , Yu Mei , Liu Xiaolei , Li Changchun 
Published: September 2023

AbstractUmbilical hernia (UH) is a prevalent congenital disorder in pigs, resulting in considerable economic losses and severe animal welfare issues. In the present study, we conducted a genome‐wide association study (GWAS) using the GeneSeek 50K Chip in 2777 pigs (Duroc,n = 1267; Landrace,n = 696; and Yorkshire,n = 814) to explore the candidate genes underlying the risk of umbilical hernia in pigs. After quality control analyses, 2748 animals and 48 524 single nucleotide polymorphisms (SNPs) were retained for subsequent GWAS analysis using the FarmCPU model. The heritability of umbilical hernias was estimated to 0.51 ± 0.04, indicating a reasonable basis for investigating genetic markers associated with this disorder. We identified 54 SNPs and 517 candidate genes that showed significant associations with susceptibility to umbilical hernia across the combined population of the three pig breeds. Gene enrichment analyses highlighted several crucial pathways for platelet degranulation, inflammatory mediator regulation of TRP channels and ion transport. These findings provide further insights into the underlying genetic architecture of umbilical hernias in pigs.
Tip‐microVapour Fast Freezing: A novel easy method for cryopreserving severe oligozoospermic samples
Authors: Dabizzi Sara , Calamai Costanza , Degl'Innocenti Selene , Boni Luca , Vignozzi Linda , Maggi Mario , Baldi Elisabetta , Muratori Monica 
Published: September 2023

AbstractBackgroundSperm cryopreservation is an important procedure for oligozoospermic subjects at risk of azoospermia and after surgical recovery of spermatozoa in non‐obstructive azoospermic men. Conventional procedures for sperm cryopreservation might be, however, not suitable for samples with a very low sperm number.ObjectivesIn this pilot study, we investigated the recoveries of sperm motility and viability in severe oligozoospermic subjects (n = 39) after cryopreservation with a tip‐microVapour Fast Freezing, a procedure previously developed by our group for men with good semen quality. Sperm DNA fragmentation was also evaluated in a second group of oligozoospermic samples (n = 16).Materials and methodsWe used a Vapour Fast Freezing procedure using 10 μL tips as carrier, and Test Yolk Buffer as freezing medium (tip‐microVapour Fast Freezing). In a subset of samples (n = 22), we compared recovery of motility and viability as obtained with tip‐microVapour Fast Freezing and with a Vapour Fast Freezing procedure using 500 μL straws. Sperm DNA fragmentation was evaluated by the sperm chromatin dispersion test.ResultsWe found a recovery rate (median [interquartile range]) of 0.29 (0.13–0.41) for progressive motility, 0.30 (0.21–0.52) for total motility and 0.48 (0.29–0.60) for viability. Interestingly, we observed that samples with the poorest motility were apparently less damaged by freezing/thawing. In a subset of samples (n = 22), we directly compared values of viability, progressive motility and total motility by freezing/thawing with tip‐microVapour Fast Freezing and Vapour Fast Freezing conducted with 500 μL straws. We found much better values of all sperm parameters in samples after freezing/thawing with tip‐microVapour Fast Freezing than with Vapour Fast Freezing in 500 μL straws: that is, progressive motility: 7.00 (3.00–8.50)% versus 2.00 (0.00–4.25)%, p < 0.001; total motility: 12.00 (8.00–16.25)% versus 6.50 (1.00–9.25)%, p < 0.001; viability: 29.75 (23.75–45.25) versus 22.50 (13.75–28.13), p < 0.001, respectively. In the second group of oligozoospermic samples, we found that tip‐microVapour Fast Freezing produced lower levels of sperm DNA fragmentation than straws (33.00 [19.75–36.00]% vs. 36.00 [22.75–41.87]%, p < 0.001).Discussion and conclusionTip‐microVapour Fast Freezing appears to be a very promising method to cryopreserve semen samples from severe oligozoospermic patients.
Decoding designers: The work of responsibility and innovation for accessibility
Authors: Usman Ramsha 
Published: September 2023

AbstractWeb users with disabilities from Pakistan critique web design methods as members of online feedback communities. One practice in web design that draws criticism is the omission of accessible features from the coding of the user interface/user experience (UI/UX) in the initial stages of web design production. The initial web design is associated with “innovation,” while accessibility becomes the responsibility of those working on the financially constrained and often delayed stage of repair and maintenance. Such a social hierarchy of design‐making propagates the exclusion of accessibility from both web design and design labor practices. Using critique from online feedback communities, two disabled Pakistani software designers highlight how accessibility norms define what innovation, responsibility, and expertise are within their domain of work. Drawing together anthropological work on accessibility and science and technology studies, this article analyzes how designers with disabilities build design systems by using critique from feedback communities, open‐sourcing, and reshaping code in a boot camp, a graduate school lab, and a corporate accessibility lab. The social work of design‐making and the material form of code therefore become tools to challenge inaccessibility and norms of innovation, responsibility, and expertise.