bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic valuation of zootechnical indicators in a tropical dairy goat production system
Authors: Silveira Naiara Cristina dos Santos , Lopes Idael Matheus Goes , De Lima Marcelo Dourado , Rodrigues Gustavo Roberto Dias , Siqueira Marco Túlio Santos , Schultz Erica Beatriz , Da Silva Natascha Almeida Marques , Raineri Camila 
Published: July 2023

The objective of our study was to promote advances in the economic valuation method of zootechnical indicators in dairy goat farming by incorporating the analysis of the modeling of biological relationships between the indicators. A Multiple Linear Regression model was developed to predict milk production as a function of zootechnical indexes and to determine which indicators influenced and in what proportion the quantity of liters sold. The absolute and relative economic values of these indicators were then calculated. Milk production was influenced by prolificacy (P=0.00325), age at kidding (P=0.01886), duration of lactation (P=< 2e-16) and parity number (P=0.00575), with absolute and relative economic values respectively as follows: $ 0,086/kid/female/year and 62.3% for prolificacy, -$ 0.001/female/month and -0.5% for age at kidding, $ 0.002/female/day and 1.5% for duration of lactation, and $ 0.051/female/parity and 36.7% for parity number. High values for the age at first kidding and interval between kiddings may be responsible for the effect of age and parity number. In conclusion, the procedures were herein employed and validated to improve the economic valuation method proved to be viable and efficient for application in dairy goat farming. In the situation analyzed, more than 90% of the economic value was obtained by prolificacy and parity number; however, the scarcity of research on these aspects of goat farming and the different indicators analyzed demonstrate the need for continuity of research in order to improve the methods so that their use in the field is applicable in more accessible ways.
Doação de órgãos: opinião, conhecimento e a intenção de doar na concepção de adolescentes
Authors: Pereira Fernanda de Oliveira , Lira Gerlene Grudka , Fernandes Flávia Emília Cavalcante Valença , Teles Maria Emília Vidal , Teles Roxana Braga de Andrade , Campos Maria Elda Alves de Lacerda , Dos Santos Joebson Maurilio Alves , De Melo Rosana Alves 
Published: July 2023

Objetivo: identificar a opinião e conhecimento de adolescentes acerca da doação de órgãos e os fatores associados a intenção em doar. Método: Estudo transversal, com dados coletados por questionário antes de uma atividade educativa, realizada em uma escola pública, com 94 alunos do 3°ano do ensino médio. Resultados: 96,8% apresentaram opiniões favoráveis à doação. Daqueles que apresentaram a intenção de doar, 37 (100,0%) já ouviram falar sobre a doação (p=0,029), bem como a maioria informou a família sobre a sua decisão 20 (54,1%), apesar de uma grande parte não ter conversado com os familiares 17 (46%) (p=0,000). Ademais, 27 (73,0%) optaram por doar órgãos de seu parente (p=0,000). Conclusão: Os jovens têm opiniões favoráveis à doação, porém a intenção de doar não acompanha a mesma proporção, indicando que ações educativas devem focar na expressão em vida da intenção de doar.
Estatística descritiva e indutiva de dados biométricos referentes a características da semente de maracujá gigante amarelo (Passiflora edulis Sims)
Authors: De Assis Janilson Pinheiro , De Lima Isaac Reinaldo Pinheiro , França Joelma de Assis , De Sousa Roberto Pequeno , Linhares Paulo César Ferreira , Rodrigues Walter Martins , De Sousa Robson Pequeno , Pereira Joaquim Odilon , Cardoso Eudes de Almeida 
Published: July 2023

Os maracujazeiros pertencem à família Passifloraceae, que é predominantemente originária da América Tropical, engloba cerca de 19 gêneros e 530 espécies, sendo a maioria pertencentes ao gênero Passiflora, aproximadamente 400 espécies. Objetivou-se avaliar a biometria da semente do maracujá. As sementes foram coletados em 2019 dentro de uma área de vegetação cultivada do campus da Universidade Federal Rural do Semi-Árido (UFERSA), situada no município de Mossoró, RN, Brasil. Posteriormente foram levados ao laboratório de fitotecnia da universidade Ufersa, para determinação das seguintes características: comprimento, largura, relação comprimento/largura, espessura e peso das sementes. As análises descritivas, gráficas e inferenciais foram realizadas utilizando o pacote estatístico software R. As variáveis comprimento, largura, relação comprimento/largura e espessura das sementes, apresentaram uma baixa amplitude de variação, exceto o peso das sementes, e valores baixos para variação relativa de todas elas, e, portanto valores ótimos obtidos para os coeficientes de variação de Pearson, dando a média aritmética dos dados uma qualidade excelente como medida representativa da tendência central. Verificou-se um razoável grau de assimetria positiva para as variáveis: largura e espessura e uma pequena assimetria negativa para as variáveis: comprimento, relação comprimento/largura, e peso das sementes, por outro lado quanto ao grau de curtose apenas o comprimento apresentou uma distribuição mais achatada do tipo platicúrtica, enquanto, a largura, relação comprimento/largura, espessura e o peso das sementes de maracujá podem ser classificados como leptocúrtica. Verificou-se também correlação linear simples positiva significativa entre o comprimento e a relação comprimento/largura, largura e relação comprimento/largura, largura e espessura, por outro lado a relação entre comprimento e largura, comprimento e espessura, comprimento e peso, relação comprimento/largura e espessura, relação comprimento/largura e peso, espessura e peso das sementes todas não significativas. Houve aderência dos dados apenas para o comprimento das sementes de forma aproximada à distribuição normal de probabilidades, já as demais variáveis analisadas neste trabalho referentes às características da semente de maracujá não se ajustaram á distribuição normal de probabilidades.
Rosia Montana, Romania: An Analysis of its Heritage Conservation from an Architectural and Planning Perspective
Authors: Florea Alexandra , Lozanovksa Mirjana 
Published: July 2023

Rosia Montana is a village located in the Apuseni Mountains, in the historical region of Transylvania in Romania. Its unique built environment has resulted from a series of contextual factors: the existence and exploitation of gold mines, the political and economic system that allowed private and state exploitation in different historical periods, the steep terrain and the spectacular landscape. From an architectural and planning point of view, the village is a traditional mining village frozen in time at the starting point of the urbanisation process.
After state mining had been interrupted at the end of the 1990s, a new mining project that requires the use of cyanide has been proposed. The heritage buildings, concentrated within and around the centre of the village, were used in the discourse of both those supporting the project and those who opposed it. On one hand, the heritage was employed to strengthen the discourse on development by selecting individual valuable buildings to be saved and renovated. On the other hand, the heritage was part of a discourse where the whole existing built fabric is valuable and needs to be protected. These two attitudes are complicated by political tactics meant to curtail small interventions into the existing fabric in order to discourage an alternative development of the area.
Through an analysis of visual material collected during fieldwork and of documents, maps and media publications, this paper navigates the complexities around heritage buildings and planning regulations that are supposed to protect valuable built environment while at the same time allow for development. In this case, tensions between heritage conservation and mining development supported by planning regulations become apparent.
PENYELESAIAN SENGKETA TANAH MELALUI PUTUSAN PERDAMAIAN OLEH PENGADILAN (Studi Kasus Putusan Pengadilan Negeri Demak Nomor:5/Pdt.g/2018/PN.DMK)
Authors: Irwan Triyanto  , Widyarini Indriasti Wardani  
Published: July 2023

Sengketa merupakan kelanjutan dari konflik, sedangkan konflik itu sendiri adalah suatu perselisihan antara dua pihak, tetapi perselisihan itu hanya dipendam dan tidak diperlihatkan dan apabila perselisihan itu diberitahukan kepada pihak lain maka akan menjadi sengketa. Timbulnya sengketa hukum mengenai tanah berawal dari pengaduan suatu pihak (orang atau badan hukum) yang berisi keberatan-keberatan dan tuntutan hak atas tanah baik terhadap status tanah, prioritas maupun kepemilikannya dengan harapan dapat memperoleh penyelesaian secara administrasi sesuai dengan ketentuan peraturan yang berlaku. Permasalahan dalam penelitian ini: 1) faktor – faktor apa yang menyebabkan penyelesaian sengketa tanah dilakukan melalui putusan perdamaian oleh pengadilan? 2) Bagaimana penyelesaian sengketa tanah melalui putusan perdamaian oleh pengadilan (Studi Kasus Putusan Pengadilan Negeri Demak Nomor: 5/PDT.G/2018/PN.DMK). 3) Bagaimana perlindungan hukum terhadap para pihak Pasca Putusan Pengadilan Negeri Demak Nomor: 5/PDT.G/2018/PN.DMK? Metode pendekatan yang digunakan dalam penelitian ini yaitu metode pendekatan yuridis normatif, spesifikasi penelitian adalah deskritif analitis, sumber dan jenis data yaitu data primer yang dilakukan dengan metode wawancara, dan data sekunder yang dilakukan dengan studi pustaka/dokumen, analisis data yang digunakan penelitian ini adalah analisis kualitatif. Hasil penelitian: 1) Faktor biaya perkara mahal dan penyelesaian sengketa yang lambat menyebabkan penyelesaian sengketa dilakukan melalui putusan perdamaian oleh pengadilan., 2) Putusan Pengadilan Negeri Demak Nomor 5/Pdt.G/2018/PN.Dmk memenuhi asas-asas/prinsip-prinsip dalam eksekusi putusan perkara perdata. 3) Perlindungan hukum terhadap pemegang hak atas tanah, berdasarkan perkara No. 5/Pdt.G/2018/PN.Dmk yaitu sebagai Penggugat (ahli waris sah Almarhum H.S.Supardi) sudah mendapat perlindungan sesuai dengan hukum yang berlaku.
PERLINDUNGAN HUKUM TERHADAP PEJABAT PEMBUAT AKTA TANAH (PPAT) DALAM PERKARA PEMBLOKIRAN BALIK NAMA OBJEK HIBAH (Putusan Mahkamah Agung Nomor 175 K/PDT/2021)
Authors: Rahma Oktavia  , Sri Subekti  
Published: July 2023

Kepemilikan hak atas tanah salah satunya dapat melalui hibah. Pejabat Umum Pembuat Akta tanah memiliki kewenangan untuk membuat akta pengalihan hak atas tanah. Penelitian ini bertujuan untuk mengetahui perlindungan hukum terhadap Pejabat Pembuat Akta Tanah (PPAT) dalam perkara pemblokiran balik nama objek hibah sesuai dengan putusan Mahkamah Agung Nomor 175/K/Pdt/2021. Perumusan masalah adalah: 1) Bagaimana pertimbangan hukum Hakim pada putusan Mahkamah Agung Nomor 175 K/Pdt/2021 tentang perkara pemblokiran balik nama objek hibah, 2) Bagaimana perlindungan hukum terhadap PPAT dalam perkara pemblokiran balik nama objek hibah sesuai dengan putusan Mahkamah Agung Nomor 175 K/Pdt/2021, 3) Bagaimana akibat hukum dari putusan Mahkamah Agung Nomor 175 K/Pdt/2021. Metode pendekatan adalah yuridis normative yang bersifat deskriptif analitis, sumber data sekunder, metode pengumpulan data dengan studi dokumen/Pustaka dan metode analisis data secara kualitatif. Berdasarkan hasil penelitian bahwa: 1) Pertimbangan Hakim Mahkamah Agung mengikuti argumentasi hukum pada putusan hakim tingkat banding menolak permohonan kasasi dari pemohon. 2) Perlindungan hukum terhadap PPAT yang diminta sebagai tergugat oleh penyidik, jaksa maupun hakim telah diatur pada Peraturan Pemerintah Republik Indonesia Nomor 24 Tahun 2016 tentang Peraturan Jabatan Pejabat Pembuat Akta Tanah, selaku pejabat umum hanya merumuskan keterangan dan pernyataan yang diperolehnya dari para penghadap. 3) Akibat hukum dari putusan yang dijatuhkan oleh Pengadilan terhadap PPAT bahwa PPAT tidak dapat dikatakan telah melakukan pelanggaran terhadap permohonan balik nama objek hibah Hak Milik tersebut, karena apa yang dituangkan dalam suatu akta adalah kehendak dari para pihak, dimana PPAT sebagai pejabat umum yang berwenang.
Pengaruh Liquidity, Solvability dan Actifity Terhadap Financial Performance Pada Perusahaan Farmasi
Authors: Sunusi Agusalim , Sahrir Sukmawati Sultan 
Published: July 2023

Aktifitas organisasi bisnis sering diperhadapkan pada kendala pengelolaan keuangan dalam pencapaian tujuan. Penelitian bertujuan mencari faktor yang mempengaruhi kinerja keuangan perusahaan Farmasi yang terdaftar di BEI pada periode 2013 – 2021. Penelitian menggunakan metode Kuantitatif dengan pendekatan Asosiatif. Populasi penelitian mencakup seluruh perusahaan Farmasi yang Listing di BEI pada tahun 2013-2021. Yang menjadi sampel penelitian adalah data rasio indikator keuangan (Likuiditas, Solvabilitas, Aktifitas dan Profitabilitas) yang diambil dari annual report perusahaan Farmasi. Teknik sampling yang digunakan adalah Purposive Sampling. Berdasarkan analisis dan pembahasan, diperoleh hasil penelitian yakni CR, ATO dan DAR, baik secara Parsial maupun Simultan, tidak berpengaruh Signifikan terhadap NPM perusahaan Farmasi.
Production of natural bitter orange (Bitter orange aurantium) sauce
Authors: Yapıcı Nane Betül , Özdemir Yüksel , Aydın Dilek , Ilya Zeynep 
Published: July 2023

Sour sauces are an important part of Turkish cuisine and the Mediterranean diet. They are generally used as a flavoring in salads, cold appetizers and various dishes such as stuffed meatballs, raw meatballs and casseroles. In this study, it was aimed to obtain a sauce with a high consistency from the juice of bitter oranges grown in the Mediterranean climate, which is not evaluated due to its bitter taste due to its high naringin content and to be used in salads or meals. Carob molasses pulp (CMP) was used in the sauce preparation process to obtain high consistency. In addition to providing high consistency, CMP has increased the nutritional value of the sauce. For this purpose, bitter orange (Bitter orange aurantium) juice was evaporated in the open boiler until it reached 25-30 ⁰Brix. After adding 2% CMP to the semi-evaporated bitter orange juice, the evaporation process was continued till it reached the final concentration of 55 ⁰Brix. The obtained sauce was evaluated in pH, total phenolic content, total antioxidant activity, color and sensory properties. As a result, the total phenolics content was 785±4.00 mg GAE/L and the total antioxidant capacity was 77±0.00 µmol TE/L. The results showed that the citrus sauce supplemented with CMP was exposed to less heat treatment and lower change in its lightness according to the control and it was liked more than the control in terms of color, consistency, taste and overall acceptability. Consequently, a new high-consistency sour bitter orange sauce was produced which was appreciated by consumers.
THÀNH PHẦN CỦA LOÀI ANOPHELES, HOẠT ĐỘNG CẮN VÀ VAI TRÒ LÂY TRUYỀN SỐT RÉT CỦA CÁC Vectơ Ở XÃ EA SƠN, HUYỆN EAKAR, TỈNH ĐẮK LẮK, 2021
Authors: Phạm Văn Quang  , Nguyễn Quang Thiều  , Trần Thanh Dương  , Vũ Việt Hưng  , Nguyễn Anh Tuấn  , Trần Thị Huyền  , Nguyễn Văn Dũng  
Published: July 2023

Một nghiên cứu cắt ngang nhằm mục đích mô tả thành phần, hoạt động cắn và
vai trò truyền của véc tơ sốt rét tháng 5 và tháng 12 năm 2021 tại xã Ea Sô,
Huyện Ea Kar, tỉnh Đắk Lắk. Các phương pháp thu thập muỗi thông thường là
được triển khai bao gồm bẫy lưới đôi dành cho người ngoài trời (24 giờ) và CDC trong nhà
bẫy đèn. Kết quả cho thấy đã xác định được 5 loài Anopheles trong tổng số 188
muỗi vằn ở xã Ea Sô. Véc tơ chính, An. dirus được thu thập trong
bìa rừng và rừng sâu lần lượt chiếm 35,71% và 96,56%. Các
mật độ An cao hơn nhiều. dirus xuất hiện vào tháng 12 nhiều hơn tháng 5 (p < 0,01). Các
hoạt động cắn của An. dirus bắt đầu từ 17h chiều đến 04h00, với một đỉnh rõ ràng
từ 18h00 đến 19h00 mật độ muỗi giảm nhanh sau 24h00. Các
tỉ lệ của An. dirus thu được từ 17h00 – 24h là 90,68% và từ 24h –
0600 chỉ còn 9,32% trong rừng sâu. Tỷ lệ nhiễm Plasmodium vivax- An.
dirus là 0,58%.
Sistem Pendukung Keputusan Kemampuan Toefl Wisudawan Sistem Informasi Stmik Indonesia Padang
Authors: Sari Mega , Purwasih Ratih , Putri Yessy Prima 
Published: July 2023

Sistem pendukung keputusan merupakan sebuah sistem yang dapat membantu memudahkan pekerjaan pengguna dalam mengambil keputusan secara tepat. Berdasarkan data penilaian dari dosen bahasa Inggris STMIK Indonesia Padang bahwa mekanisme pengambilan keputusan penilaian TOEFL wisudawan sistem informasi STMIK Indonesia Padang membutuhkan waktu yang lama. Karena jumlah peserta yang cukup banyak sehingga membuat pihak dosen dan tim penilai mengalami kesulitan dalam memproses data peserta, maka diperlukannya sebuah sistem pendukung keputusan penilaian kemampuan berbicara bahasa Inggris pada STMIK tersebut. Sistem pendukung keputusan terdapat berbagai metode salah satunya metode weight product (wp). Metode weight product (wp) merupakan sebuah metode pengevaluasian beberapa alternatif terhadap sekumpulan atribut atau kriteria. Sistem pendukung keputusan penilaian kemampuan berbicara bahasa Inggris mahasiswa STMIK Indonesia Padang menggunakan metode weight product (wp) dirancang dengan menggunakan bahasa pemograman PHP dan MySql sebagai basis datanya. Hasil dari penelitian ini diharapkam sistem pendukung keputusan dengan menggunakan metode WP berbasis website yang dapat membantu meringankan pekerjaan dosen dan tim penilai dalam memberikan penilaian secara mudah, tepat dan jelas dengan keaadaan yang tidak ambigu.
FAKTOR YANG BERHUBUNGAN DENGAN TINGGINYA PENGGUNAAN KB HORMONAL SUNTIK PADA PUS USIA DI ATAS 40 TAHUN DI PMB “NMS”
Authors: Ni Made Sumberhati  , Kadek Ayu Suarmini  
Published: July 2023

Kontrasepsi merupakan salah satu upaya untuk mencegah terjadinya kehamilan. Upaya itu dapat bersifat sementara, dapat pula bersifat permanen. Pada saat ini telah banyak beredar berbagai macam alat kontrasepsi. Macam-macam metode kontrasepsi tersebut adalah Intra Uterine Device (IUD), implant, kondom, suntik, metode operatif untuk wanita (MOW), metode operatif untuk pria (MOP), dan kontrasepsi pil. Alat kontrasepsi hendaknya memenuhi syarat yaitu aman pemakaiannya dan dapat dipercaya, efek samping yang merugikan tidak ada, lama kerjanya dapat diatur keinginan, tidak mengganggu hubungan seksual, harganya murah dan dapat diterima oleh pasangan suami istri. Penelitian ini menggunakan pendekatan kualitatif. Jenis penelitian ini adalah penelitian survei analitik. Disebut penelitian survey analitik karena peneliti mencoba mencari hubungan antarvariabel. Pada penelitian ini dilakukan analisis terhadap data yang dikumpulkan, karena itu pada penelitian perlu dibuat hipotesis. Desain atau rancangan penelitian yang digunakan dalam penelitian ini adalah cross sectional. Dari hasil penelitian didapatkan adanya hubungan antara pengetahuan dan jarak kelahiran terhadap tingginyya penggunaan kontrasepsi hormonal suntik. Sedangkan tidak ada pengaruh atau hubungan pada paritas dengan pingginya penggunaan kontrasepsi hormonal suntik.
Identifikasi Drug Related Problems Potensial Kategori Interaksi Obat Pada Pasien Hipertensi Geriatrik di Instalasi Rawat Inap Rumah Sakit XYZ Tangerang
Authors: Saputro Muhamad Fajar , Putra Ari Permana , Aisyah Rizka 
Published: July 2023

Hipertensi merupakan penyakit yang berhubungan dengan tekanan darah manusia. Diagnosis dari hipertensi dapat di tegakkan jika rata-rata hasil pemeriksaan darah pada diastolik ≥90 mmHg dan sistolik ≥120 mmHg. Penurunan elastisitas pembuluh darah serta penyempitan pembuluh darah arteri pada lansia merupakan salah satu faktor resiko terjadinya hipertensi.
Tujuan dalam penelitian ini adalah untuk mengidentifikasi DRPs kategoro interaksi obat meliputi interkasi obat potensial, interaksi obat berdasarkan mekanisme, dan interaksi berdasarkan level signifikansinya pada pasien hipertensi geriatrik di instalasi rawat inap Rumah Sakit XYZ Tangerang.
Penelitian ini merupakan penelitian non-eksperimental deskriptif analitik dengan pengumpulan data secara retrospektif menggunakan data berdasarkan catatan medis di Rumah Sakit XYZ Tangerang, pengambilan sampel menggukan metode purposive sampling.
Berdasarakan hasil penelitian yang dilakukan di Rumah Sakit XYZ Tangerang bahwa; Interaksi obat potensial terjadi pada 20 (48,78%) pasien dengan jumlah kasus interaksi sebanyak 61 kasus; interaksi yang terjadi pada fase farmakokinetika sebanyak 20 kasus (32,79%) dan interaksi yang tidak diketahui mekanismenya sebanyak 19 kasus (31,15%); berdasarkan level signifikansinya terjadi 10 kasus (16,39%) interaksi yang mempunyai level signifikansi I, level signifikansi II berjumlah 10 kasus (16,39%), level signifikansi III sejumlah 4 kasus (6,56%), level signifikansi IV sejumlah 18 kasus (29,51%), level signifikansi V sejumlah 14 kasus (22,95%) dan interaksi yang belum diketahui level signifikansinya sejumlah 5 kasus (8,20%).
Design of Smart Locker Door Using Quality Function Deployment Based on ATMega 2560 Microcontroller
Authors: Filhaq Gozy , Aprianto Sudrajat , Alfianto Harly 
Published: July 2023

Smart Locker system to provide more security for the house that is a place to live to avoid losses and negative impacts of criminal case actions with incrimination. This study designed door security with a door bar control system that can be done from outside the house using Android and a keypad so that the bar behind the door automatically closes and opens according to the password code command entered by the user or homeowner. Consumer desires home security systems using the QFD (Quality Function Deployment) method. The QFD method will conclude that a better door security product design is needed, with home security system updates as needed. Consumers need thirteen dimensions with three priorities with the highest value, namely securing the door of the house with a shape that matches the door with a rating of 4.55, Securing the door of the house has an alarm system with a rating of 4.50, Securing the door of the house is easy to use for the owner. The intelligent locker design is based on ATMega 2560 Microcontroller, which functions to program other components so that they can work according to the data that has been inputted
The Most Common Mutations in the CFTR Gene in the Population of Bosnia and Herzegovina
Authors: Mačkić-Ðurović Mirela , Kiseljaković Emina , Aganović-Mušinović Izeta , Rasumović Admir 
Published: July 2023

Aims: Cystic fibrosis is an autosomal recessive multisystem disease caused by a mutation of the CFTR gene. To date, more than 1900 mutations of this gene are known. Studies have shown that the most common mutation is delF508. In Bosnia and Herzegovina, the prevalence of individual mutations in the general population has not been thoroughly studied, so this study aimed to determine the prevalence of the mutation concerning the countries of the region and the rest of the world.
Study Design: Retrospective study.
Place and Duration of Study: Thirty-nine subjects with suspected Cystic fibrosis were referred to the Center for Genetics of the Medical Faculty in Sarajevo between 2018-2020.
Methodology: 29 common CFTR gene mutations were analysed with the ELUCIGENE CF29 v2 kit (Elucigene Diagnostics, UK) using four multiplex PCR.
Results: The most common mutation in our study was the F508 deletion, present in 14 subjects (73.68%). R347P and G542X mutations were confirmed in two subjects in the heterozygous state in combination with delF508 (M) 5.26% of each of these mutations. 621+1G>T was found in a homozygous state in one subject, while in another, it was in a heterozygous state in combination with delF508(M) mutation, 10.52%. Mutation 2184 delA was found in one subject in the homozygous state with a total frequency of 5.26%.
Conclusion: Subjects with cystic fibrosis in Bosnia and Herzegovina are most often carriers of the delF508 mutation. Considering the existence of many mutations and that it is difficult to test them all, targeting the most common mutations in a clinical environment might help in approving therapy, and increasing patients’ quality of life.