bluuebunny/crossref_metadata_2025_split huggingface dataset:
The future of energy harvesting: A brief review of MXenes‐based triboelectric nanogenerators
Authors: Mohan Raja , Ali Fathilah 
Published: July 2023

AbstractTriboelectric nanogenerators (TENGs) have shown immense potential as self‐powering devices for energy harvesting, electronics, and self‐powered sensing devices. However, the performance of TENGs largely depends on the materials used, therefore, it is crucial to select appropriate materials. While dielectric polymers, metals, and inorganic materials have been commonly employed as active materials for TENGs, there is a need to explore new materials that offer improved performance. One promising material is two‐dimensional MXenes, which have shown exciting potential in various applications, including wearable sensors and electrochemical energy storage. For this reason, further research is needed to fully evaluate the performance of MXenes‐based TENGs and to determine their suitability for practical applications. This review emphasizes the significance of material selection in order to optimize the performance of triboelectric nanogenerators (TENGs). Here, the mechanism of TENGs is clearly explained for devices that convert mechanical energy into electric energy. The concept of the triboelectric effect is also described, which generates charge density on material surfaces, along with various types of TENG working modes. The selection of materials is thoroughly discussed, highlighting the growing interest in polymeric and biopolymeric materials, as well as functionalized and inorganic triboelectric materials. Also, exploration of materials that can enhance the output of TENGs, such as chemical modification techniques and the utilization of 2D materials like graphene and MXenes to improve triboelectricity is also included. The synthesis methods and techniques for MXenes are explored in detail. Furthermore, the performance of MXenes‐based TENGs for energy harvesting and self‐powered sensing is evaluated, and their potential applications in wearable devices are assessed. The study concludes by providing recommendations for future research on MXenes‐based TENGs and their applications in wearable devices.
Reevaluation of sodium thiosulfate otoprotection using the consensus International Society of Paediatric Oncology Ototoxicity Scale: A report from the Children's Oncology Group study ACCL0431
Authors: Orgel Etan , Knight Kristin R. , Villaluna Doojduen , Krailo Mark , Esbenshade Adam J. , Sung Lillian , Freyer David R. 
Published: July 2023

AbstractIn two randomized trials (Children's Oncology Group ACCL0431 and International Childhood Liver Tumour Strategy Group SIOPEL‐6), sodium thiosulfate (STS) demonstrated efficacy in preventing cisplatin‐induced hearing loss (CIHL). However, the measures used in those trials have been superseded by the consensus International Society of Paediatric Oncology (SIOP) Ototoxicity Scale. To provide benchmark data for STS efficacy when using this contemporary scale, we reanalyzed ACCL0431 hearing outcomes with the SIOP scale and using multiple timepoints. Compared to the control arm, STS significantly reduced CIHL when assessed by the SIOP scale across these different approaches. These results provide critical data to inform treatment discussions and support future potential trial designs comparing otoprotectants.
Biodegradable polymer‐based hydrogel as a bioactive carrier for dermatological cosmetics and pharmaceutical applications
Authors: Maijan Pattarawadee , Kongseng Piyawan , Bilhman Siwaporn , Dumjun Krittima , Wannaboworn Sirilak , Chantarak Sirinya , Voravuthikunchai Supayang P. 
Published: July 2023

AbstractA novel biodegradable interpenetrating polymer network hydrogel impregnated with a plant extract was designed using a simple one‐pot free radical polymerization of polyacrylamide (PAM), poly(vinyl alcohol) (PVA) and gelatin (Gel). PAM/PVA/Gel hydrogels with different Gel contents (Gel‐0–Gel‐40) reached a maximum water absorbency of 1443%, which was approximately three times greater than PAM hydrogel. Biocompatibility assessment of all hydrogels on L929 fibroblast cells demonstrated no toxicity. Gel‐10 hydrogel with a water absorbency of 1120% presented the optimal tensile strength of 363 kPa. The compressive modulus of Gel‐10 hydrogel was 36.2 kPa with the ability to maintain shape under load. Gel‐10 hydrogel demonstrated a good adhesive property on various surfaces including paper, glass, aluminium and skin. A release study revealed a sustained release characteristic which involved Fickian diffusion. A plant extract,Quercus infectoria(Qi), was successfully impregnated as a bioactive agent into Gel‐10 hydrogel and demonstrated a broad spectrum of antibacterial activity against both Gram‐positive and Gram‐negative bacteria. In addition, theQi‐impregnated hydrogel possesses an excellent radical scavenging activity with 94.6% inhibition and antityrosinase activity with 88.4% inhibition. Studies on biodegradation in soil indicated that the external surfaces of Gel‐10 hydrogel were destroyed. The percentage weight loss of Gel‐10 hydrogel was 66.7%. Additionally, the water absorbency of Gel‐10 after a soil burial test was significantly decreased (421%), compared with 1120% before the test (P < 0.001). Gel‐10 hydrogel could be applied as a bioactive carrier in dermatological cosmetics and pharmaceutical products to prevent infections, deleterious effects from free radicals, and skin pigmentation disorders. © 2023 Society of Industrial Chemistry.
Registration of 12 soft red winter partial waxy wheat germplasms carrying one or two null alleles at the Wx loci
Authors: Ma Fengyun , Sturbaum Anne , Baik Byung‐Kee 
Published: July 2023

AbstractPartial waxy wheat (Triticum aestivum L.) with reduced starch amylose content is potentially desirable for making bread with maintained moistness and extended shelf life and noodles with improved sensory acceptance. The USDA‐ARS developed and released 12 soft red winter (SRW) partial waxy wheat germplasms—SWQL‐K‐A‐1 (Reg. no. GP‐1077, PI 702623), SWQL‐K‐B‐1 (Reg. no. GP‐1080, PI 702626), SWQL‐K‐D‐1 (Reg. no. GP‐1082, PI 702628), SWQL‐K‐AB‐1 (Reg. no. GP‐1078, PI 702624), SWQL‐K‐AD‐1 (Reg. no. GP‐1079, PI 702625), SWQL‐K‐BD‐2 (Reg. no. GP‐1081, PI 702627), SWQL‐W‐A‐5 (Reg. no. GP‐1083, PI 702629), SWQL‐W‐B‐1 (Reg. no. GP‐1086, PI 702633), SWQL‐W‐D‐2 (Reg. no. GP‐1088, PI 702636), SWQL‐W‐AB‐4 (Reg. no. GP‐1084, PI 702630), SWQL‐W‐AD‐2 (Reg. no. GP‐1085, PI 702631), and SWQL‐W‐BD‐1 (Reg. no. GP‐1087, PI 702634)—by the introgression of one or two null alleles at the Wx loci from a soft spring waxy wheat germplasm to two SRW wheat cultivars. Twelve partial waxy wheat germplasms were selected from backcross‐four or backcross‐five derivatives of SRW wheat cultivars ‘Kristy’ and ‘Wilson’ (99ID490/5*Kristy and 99ID490/6*Wilson, respectively) by marker‐assisted selection. The kernel hardness of partial waxy wheat germplasms in Kristy and Wilson backgrounds ranged from 62.7 to 64.3 and from 28.4 to 31.7, respectively, whereas that of the corresponding wild type was 58.6 and 30.3, respectively. Amylose contents of isolated starches ranged from 23.9% to 25.8% in single‐null partial waxy wheat germplasms, from 18.4% to 24.3% in double‐null partial waxy wheat germplasms, and from 26.8% to 27.1% in parents and wild types. These partial waxy wheat germplasms would be useful for the development of SRW partial waxy wheat cultivars adapted to the eastern region of the United States and extending the use of SRW wheat in products that require a reduced starch amylose content.
Evidence‐based practice in physiotherapy in Argentina: Barriers, perceptions and behaviors
Authors: Bevacqua Nicolás , Intelangelo Leonardo 
Published: July 2023

AbstractBackground and PurposeEvidence‐based practice (EBP) has been widely implemented in different areas of biomedical sciences. However, no precedents in Argentina have investigated the data regarding the knowledge and difficulties related to EBP in physiotherapists. The purpose was to describe the self‐reported behavior, knowledge, skills, opinion, and barriers related to the EBP of Argentinian physiotherapists.MethodsA customized descriptive survey was conducted among 289 physical therapists in Argentina. The data were analyzed descriptively.ResultsThe response rate was 56% (163/289). Argentinian physiotherapists update themselves through scientific articles, meetings, congresses, and courses. They reported having sufficient knowledge to use EBP, informing patients about treatment options, and considering their choices in the decision‐making process. However, there were inconsistencies in responses regarding experience with EBP during undergraduate or postgraduate studies. The most frequently reported barriers were lack of time, difficulty in understanding statistics, and difficulties with the English language of scientific articles.DiscussionEBP in Argentine physiotherapists is still poorly understood. Time, language, and difficulties in understanding statistics are the most important barriers to the implementation of EBP. Undergraduate and postgraduate courses are warranted to improve the clinical decision‐making process.
Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3
Authors: Noonan Jennifer D. , Beech Robin N. 
Published: July 2023

AbstractNicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface. Resistance to cholinesterase 3 (RIC‐3) is an endoplasmic reticulum protein that physically interacts with nascent pLGIC subunits and promotes their oligomerization. It is not known why some N‐AChRs require RIC‐3 in heterologous expression systems, whereas others do not. Previously we reported that the ACR‐16 N‐AChR from the parasitic nematode Dracunculus medinensis does not require RIC‐3 in Xenopus laevis oocytes. This is unusual because all other nematode ACR‐16, like the closely related Ascaris suum ACR‐16, require RIC‐3. Their high sequence similarity limits the number of amino acids that may be responsible, and the goal of this study was to identify them. A series of chimeras and point mutations between A. suum and D. medinensis ACR‐16, followed by functional characterization with electrophysiology, identified two residues that account for a majority of the receptor requirement for RIC‐3. ACR‐16 with R/K159 in the cys‐loop and I504 in the C‐terminal tail did not require RIC‐3 for functional expression. Mutating either of these to R/K159E or I504T, residues found in other nematode ACR‐16, conferred a RIC‐3 requirement. Our results agree with previous studies showing that these regions interact and are involved in receptor synthesis. Although it is currently unclear what precise mechanism they regulate, these residues may be critical during specific subunit folding and/or assembly cascades that RIC‐3 may promote.
Global analysis of kinetics reveals the role of secondary nucleation in recombinant spider silk self‐assembly
Authors: Hovanová Veronika , Hovan Andrej , Žoldák Gabriel , Sedlák Erik , Humenik Martin 
Published: July 2023

AbstractRecombinant spider silk proteins can be prepared in scalable fermentation processes and have been proven as sources of biomaterials for biomedical and technical applications. Nanofibrils, formed through the self‐assembly of these proteins, possess unique structural and mechanical properties, serving as fundamental building blocks for the fabrication of micro‐ and nanostructured scaffolds. Despite significant progress in utilizing nanofibrils‐based morphologies of recombinant spider silk proteins, a comprehensive understanding of the molecular mechanisms of nanofibrils self‐assembly remains a challenge. Here, a detailed kinetic study of nanofibril formation from a recombinant spider silk protein eADF4(C16) in dependence on the protein concentration, seeding, and temperature is provided. For the global fitting of kinetic data obtained during the fibril formation, we utilized the online platform AmyloFit. Evaluation of the data revealed that the self‐assembly mechanism of recombinant spider silk is dominated by secondary nucleation. Thermodynamic analyses show that both primary and secondary nucleations, as well as the elongation step of the eADF4(C16), are endothermic processes.
Application of physiologically based pharmacokinetic modeling to understand real‐world outcomes in patients receiving imatinib for chronic myeloid leukemia
Authors: Adattini Josephine A. , Adiwidjaja Jeffry , Gross Annette S. , McLachlan Andrew J. 
Published: July 2023

AbstractWe aimed to use physiologically based pharmacokinetic (PBPK) modeling and simulation to predict imatinib steady‐state plasma exposure in patients with chronic myeloid leukemia (CML) to investigate variability in outcomes. A validated imatinib PBPK model (Simcyp Simulator) was used to predict imatinib AUCss, Css,min and Css,max for patients with CML (n = 68) from a real‐world retrospective observational study. Differences in imatinib exposure were evaluated based on clinical outcomes, (a) Early Molecular Response (EMR) achievement and (b) occurrence of grade ≥3 adverse drug reactions (ADRs), using the Kruskal‐Wallis rank sum test. Sensitivity analyses explored the influence of patient characteristics and drug interactions on imatinib exposure. Simulated imatinib exposure was significantly higher in patients who achieved EMR compared to patients who did not (geometric mean AUC0‐24,ss 51.2 vs. 42.7 μg h mL−1, p < 0.05; Css,min 1.1 vs. 0.9 μg mL−1, p < 0.05; Css,max 3.4 vs. 2.8 μg mL−1, p < 0.05). Patients who experienced grade ≥3 ADRs had a significantly higher simulated imatinib exposure compared to patients who did not (AUC0‐24,ss 56.1 vs. 45.9 μg h mL−1, p < 0.05; Css,min 1.2 vs. 1.0 μg mL−1, p < 0.05; Css,max 3.7 vs. 3.0 μg mL−1, p < 0.05). Simulations identified a range of patient (sex, age, weight, abundance of hepatic CYP2C8 and CYP3A4, α1‐acid glycoprotein concentrations, liver and kidney function) and medication‐related factors (dose, concomitant CYP2C8 modulators) contributing to the inter‐individual variability in imatinib exposure. Relationships between imatinib plasma exposure, EMR achievement and ADRs support the rationale for therapeutic drug monitoring to guide imatinib dosing to achieve optimal outcomes in CML.
Expression and function of opsin genes associated with phototaxis in Zeugodacus cucurbitae Coquillett (Diptera: Tephritidae)
Authors: Huang Mei , Meng Jian‐Yu , Zhou Lv , Yu Chun , Zhang Chang‐Yu 
Published: July 2023

AbstractBackgroundZeugodacus cucuribitae is a major agricultural pest that causes significant damage to varieties of plants. Vision plays a critical role in phototactic behavior of herbivorous insects. However, the effect of opsin on the phototactic behavior in Z. cucuribitae remains unknown. The aim of this research is to explore the key opsin genes that associate with phototaxis behavior of Z. cucurbitae.ResultsFive opsin genes were identified and their expression patterns were analyzed. The relative expression levels of ZcRh1, ZcRh4 and ZcRh6 were highest in 4‐day‐old larvae, ZcRh2 and ZcRh3 were highest in 3rd‐instar larvae and 5‐day‐old pupae, respectively. Furthermore, five opsin genes had the highest expression levels in compound eyes, followed by the antennae and head, whereas the lower occurred in other tissues. The expression of the long‐wavelength‐sensitive (LW) opsins first decreased and then increased under green light exposure. In contrast, the expression of ultraviolet‐sensitive (UV) opsins first increased and then decreased with the duration of UV exposure. Silencing of LW opsin (dsZcRh1, dsZcRh2, and dsZcRh6) and UV opsin (dsZcRh3 and dsZcRh4) reduced the phototactic efficiency of Z. cucurbitae to green light by 52.27%, 60.72%, and 67.89%, and to UV light by 68.59% and 61.73%, respectively.ConclusionThe results indicate that RNAi inhibited the expression of opsin, thereby inhibiting the phototaxis of Z. cucurbitae. This result provides theoretical support for the physical control of Z. cucurbitae and lays the foundation for further exploration of the mechanism of insect phototaxis. © 2023 Society of Chemical Industry.
Guiding model‐driven combination dose selection using multi‐objective synergy optimization
Authors: Gevertz Jana L. , Kareva Irina 
Published: July 2023

AbstractDespite the growing appreciation that the future of cancer treatment lies in combination therapies, finding the right drugs to combine and the optimal way to combine them remains a nontrivial task. Herein, we introduce the Multi‐Objective Optimization of Combination Synergy – Dose Selection (MOOCS‐DS) method for using drug synergy as a tool for guiding dose selection for a combination of preselected compounds. This method decouples synergy of potency (SoP) and synergy of efficacy (SoE) and identifies Pareto optimal solutions in a multi‐objective synergy space. Using a toy combination therapy model, we explore properties of the MOOCS‐DS algorithm, including how optimal dose selection can be influenced by the metric used to define SoP and SoE. We also demonstrate the potential of our approach to guide dose and schedule selection using a model fit to preclinical data of the combination of the PD‐1 checkpoint inhibitor pembrolizumab and the anti‐angiogenic drug bevacizumab on two lung cancer cell lines. The identification of optimally synergistic combination doses has the potential to inform preclinical experimental design and improve the success rates of combination therapies.Jel classificationDose Finding in Oncology
Biological and theoretical investigation of cyclohexylamine dithiocarbamate metal (II) complexes
Authors: Mahdi Wedyan H. , Faihan Ahmed S. , Jirjes Hayfa M. , Al‐Mutairi Adibah M. , Alshehri Amal M. A. , Alotaibi Sarah A. , Saleh Abdulrahman M. , Hatshan Mohammad R. , Al‐Janabi Ahmed S. M. , Kuniyil Mufsir , Shaik Baji , Adil Syed Farooq 
Published: July 2023

AbstractA series of metal (II) complexes of N‐cyclohexyl amine dithiocarbamate ligand are synthesized and characterized by Fourier transform infrared, 1H, 13C NMR, mass spectroscopy, and elemental analysis. The surface structural pattern of the prepared complexes were investigated by scanning electron microscope and X‐ray diffraction techniques. The prepared complexes possessed crystalline characteristic with size average ranging from 16 to 30 nm. Moreover, the biological activity of the synthesized complexes were tested against Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. Among the prepared complexes, copper (II) complex displayed the highest activity. In addition, molecular docking study was performed against bacterial tyrosinase enzyme which showed good binding interactions and is in agreement with the experimental findings. Furthermore, the in silico toxicity studies reveal that the complexes are mostly non‐irritant with mild toxicity. Different quantum parameters including electron affinity, ionization energy, dipole moment, hardness and vibrational frequencies were calculated for the ligand and its complexes using Gaussian 09 program and B3LYP/SDD level of theory.
Value investing via Bayesian inference
Authors: Huefner Bernd , Rueenaufer Marcel , Boesch Martin 
Published: July 2023

AbstractClassic value investing à la Graham & Dodd (Security analysis: The classic, McGrawHill, New York, 1934) focuses on selecting stocks that seem cheap relative to their intrinsic value and fundamental quality. We use Bayesian inference to account for a large amount of uncertainty within intrinsic value estimation. We find that an undervalued‐minus‐overvalued factor that invests in cheap quality stocks and sells expensive junk stocks selected via Bayesian inference yields high risk‐adjusted returns and Sharpe ratios for equal‐weighted portfolios. We also find that using value‐weighted portfolios introduces size‐based dilutions and shifts the focus away from actual quality characteristics like profitability, payout, safety, and past growth. Our findings suggest that while the relative benefit of accounting for uncertainty via Bayesian inference is not large over shorter holding periods, it pays off for investment horizons longer than a month.
Selective Proteolysis of Activated Transcriptional Factor by NIR‐Responsive Palindromic DNA Thalidomide Conjugate Inhibits the Canonical Smad Pathway
Authors: Hou Min , Guo Rui , Ren Tianyu , Wang Tao , Jiang Jian‐Hui , He Jianjun 
Published: July 2023

AbstractDysfunctional transcription factors that activate abnormal expressions of specific proteins are often associated with the progression of various diseases. Despite being attractive drug targets, the lack of druggable sites has dramatically hindered their drug development. The emergence of proteolysis targeting chimeras (PROTACs) has revitalized the drug development of many conventional hard‐to‐drug protein targets. Here, the use of a palindromic double‐strand DNA thalidomide conjugate (PASTE) to selectively bind and induce proteolysis of targeted activated transcription factor (PROTAF) is reported. The selective proteolysis of the dimerized phosphorylated receptor‐regulated Smad2/3 and inhibition of the canonical Smad pathway validates PASTE‐mediated PROTAF. Further aptamer‐guided active delivery of PASTE and near‐infrared light‐triggered PROTAF are demonstrated. Great potential in using PASTE for the selective degradation of the activated transcription factor is seen, providing a powerful tool for studying signaling pathways and developing precision medicines.
Identifying And Unveiling the Role of Multivalent Metal States for Bidirectional UOR and HER Over Ni, Mo‐Trithiocyanuric Based Coordination Polymer
Authors: Liu Mengying , Zou Wenhong , Cong Jing , Su Nan , Qiu Silong , Hou Linxi 
Published: July 2023

AbstractUrea oxidation reaction (UOR), an ideal alternative to oxygen evolution reaction (OER), has received increasing attention for realizing energy‐saving H2 production and relieving pollutant degradation. Normally, most studied Ni‐based UOR catalysts pre‐oxidate to NiOOH and then act as active sites. However, the unpredictable transformation of the catalyst's structure and its dissolution and leaching, may complicate the accuracy of mechanism studies and limit its further applications. Herein, a novel self‐supported bimetallic Mo‐Ni‐C3N3S3 coordination polymers (Mo‐NT@NF) with strong metal–ligand interactions and different H2O/urea adsorption energy are prepared, which realize a bidirectional UOR/hydrogen evolution reaction (HER) reaction pathway. A series of Mo‐NT@NF is prepared through a one‐step mild solvothermal method and their multivalent metal states and HER/UOR performance relationship is evaluated. Combining catalytic kinetics, in situ electrochemical spectroscopic characterization, and density‐functional theory (DFT) calculations, a bidirectional catalytic pathway is proposed by N, S‐anchored Mo5+ and reconstruction‐free Ni3+ sites for catalytic active center of HER and UOR, respectively. The effective anchoring of the metal sites and the fast transfer of the intermediate H* by N and S in the ligand C3N3S3H3 further contribute to the fast kinetic catalysis. Ultimately, the coupled HER||UOR system with Mo‐NT@NF as the electrodes can achieve energy‐efficient overall‐urea electrolysis for H2 production.