bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sosialisasi Fungsi Legislasi Badan Permusyawaratan Desa (BPD) di Desa Pledo Kecamatan Witihama Kabupaten Flores Timur
Authors: Servatius Rodriques , Susu Mikael Thomas , Boro Veronika Ina Asan , Kosat Emanuel , Lamawuran Yosef Dionisius 
Published: January 2025

ABSTRAK Pengabdian ini dilakukan di Desa Pledo Kecamatan Witihama Kabupaten Flores Timur. Kegiatan ini dilakukan menyusul fakta bahwa masih banyak anggota BPD yang belum memahami secara detail Tupoksi BPD dan minimnya keterampilan teknis penyusunan Perdes. Dari pengamatan dan wawancara awal, diketahui bahwa kurang produktifnya BPD disebabkan oleh sejumlah faktor, antara lain kualitas SDM, kurangnya wawasan dan pengetahuan dan minimnya keterampilan teknis-administrasi. Kegiatan ini bertujuan untuk memberikan informasi dan pengetahuan tentang fungsi legislasi bagi anggota BPD Pledo demi peningkatan pengetahuan dan keterampilan teknis anggota BPD dalam merumuskan dan menetapkan Perdes. Tim PkM yang terdiri dari dosen Fakultas Ilmu Sosial dan Ilmu Politik yang berjumlah 3 orang. Hasil evaluasi pre test dan post menunjukan terjadinya peningkatan pengetahuan dan pemahaman dari para peserta tentang perumusan dan penetapan Perdes. Kata Kunci: Sosialisasi, Fungsi Legislasi, Peraturan Desa, BPD ABSTRACT This service was conducted in Pledo Village, Witihama Sub-district, East Flores Regency. This activity was carried out following the fact that there are still many BPD members who do not understand in detail the Tupoksi of the BPD and the lack of technical skills in drafting Perdes. From initial observations and interviews, it was found that the lack of productivity of the BPD is caused by a number of factors, including the quality of human resources, lack of insight and knowledge and lack of technical-administrative skills. This activity aims to provide information and knowledge about the legislative function for members of the Pledo BPD in order to increase the knowledge and technical skills of BPD members in formulating and stipulating Perdes. The PkM team consisting of 3 lecturers from the Faculty of Social and Political Sciences. The results of the pre-test and post evaluation showed an increase in the knowledge and understanding of the participants about the formulation and stipulation of Perdes. Keywords: Socialization, Legislation Function, Village Regulation, BPD
Berani (Bunda Responsif Atas Bahaya Nyala Api): Penerapan K3 Berbasis Masyarakat untuk Mitigasi Risiko Kebakaran Rumah Tangga K3 Rumah Tangga: “Berani” Jadi Pionir Keselamatan Keluarga
Authors: Maharja Rizky , Panggeleng Andi Mifta Farid , Abdullah Anisa Dwirizky 
Published: January 2025

ABSTRAK Bahaya nyala api merupakan salah satu bahaya di tingkat rumah tangga yang jika tidak diatasi sedini mungkin maka dapat menyebabkan kebakaran. Kegiatan PkM BERANI (Bunda Responsif Atasi Nyala Api) bertujuan untuk meningkatkan pengetahuan mitra tentang bahaya nyala api dan peningkatan keterampilan dalam pemadam api. Kegiatan pengabdian kepada masyarakat ini dilaksanakan melalui sosialisasi tentang bahaya nyala api dan pelatihan pemadaman api menggunakan karung goni dan alat pemadam api ringan. Rata-rata peningkatan pengetahuan bahaya nyala api mencapai 97.44%. Angka ini melampaui indikator capaian yang sebelumnya ditentukan yaitu 95%. Perbedaan pengetahuan ini didukung dengan hasil uji statistik pada Tabel 4 dengan p-value < 0,05 yang menunjukkan adanya perbedaan pengetahuan sebelum dan sesudah sosialisasi dilakukan. Rata-rata peningkatan keterampilan penggunaan karung goni dan APAR yaitu 96%. Angka ini melampaui indikator capaian yang sebelumnya ditentukan yaitu 95%. Program PkM BERANI telah berhasil meningkatkan kesadaran dan kemampuan ibu rumah tangga dalam menghadapi bahaya kebakaran. Hasil yang dicapai menunjukkan keberhasilan program dalam mencapai tujuannya. Kata Kunci: Nyala Api, Kebakaran, Ibu Rumah Tangga, Pemadaman Api ABSTRACT One of the most significant hazards at the household level is the potential for fire caused by flame hazards. These hazards, if not addressed promptly, can lead to a fire. The objective of this study is to: The objective of the PkM BERANI (Bunda Responsif Atasi Nyala Api) activity is twofold: firstly, to enhance the knowledge of partners with regard to the dangers of flames and secondly, to develop their abilities in fire extinguishing. This community service activity is conducted through the dissemination of information regarding the hazards of flames and the training of fire extinguishing techniques using gunny sacks and light fire extinguishers. The mean increase in knowledge regarding the dangers of flames was 97.44%. This figure exceeds the previously determined achievement indicator of 95%. The discrepancy in knowledge is corroborated by the findings of the statistical tests presented in Table 1, with a p-value <0.05, which demonstrates a notable divergence in knowledge between the pre-and post-socialization phases. The mean increase in proficiency in the use of burlap sacks and fire extinguishers was 96%. This figure exceeds the previously determined achievement indicator of 95%. It can be concluded that the PkM BERANI program has successfully increased the awareness and ability of housewives to deal with fire hazards. The results achieved demonstrate the success of the program in achieving its objectives. Keywords: Flame, Fire, Housewife, Fire Fighting
Mobilidade urbana e os meios de locomoção na percepção de estudantes do ensino médio: um olhar a partir do Projeto Nós Propomos! - cidadania e inovação na educação geográfica
Authors: Basquerote Adilson Tadeu , Rosa Maria Eduarda , Fertig Bastos Ana Paula , Moser Bertoldi Gabriel 
Published: January 2025

O estudo identificou as percepções de estudantes do Ensino Médio, acerca dos meios de locomoção e as condições de mobilidade urbana na cidade de Rio do Sul (SC). Trata-se de um estudo de natureza qualitativa, desenvolvido no segundo semestre do ano de 2022, por estudantes de uma escola privada da região Sul do Brasil, no âmbito do projeto Nós Propomos! - Cidadania e Inovação na Educação Geográfica (NP). Para tanto, a coleta de dados aconteceu a partir de estudo bibliográfico, saídas a campo e um questionário composto de doze por perguntas abertas e fechadas, respondido pelos estudantes. Os dados evidenciaram as adversidades presentes nos meios de locomoção e indicaram que a maior parcela dos estudantes utiliza meios de transporte individuais para o deslocamento até a escola ou trabalho. Destacou-se as fragilidades na qualidade do transporte público coletivo, como melhorias nas condições de higiene, comodidade e aumento da grade de horários. Salienta-se a importância da presença das ciclovias nos bairros e aponta-se as bicicletas como o meio de locomoção mais saudável. Por fim, identifica-se os pontos de maior gargalo de mobilidade, de lentidão, de carência de acessibilidade e os bairros com maior demanda de infraestrutura de mobilidade.
Territórios da Educação: uma abordagem geográfica sobre a rede de ensino profissional e tecnológico no Estado do Rio de Janeiro
Authors: De Almeida Adjovanes T. Silva , Borges Marcelo Henrique da Silva 
Published: January 2025

O presente artigo pretende analisar os fatores que justificam a presença da rede federal de Ensino Profissional e Tecnológico (EPT) no Estado do Rio de Janeiro, a partir de algumas categorias geográficas, permitindo compreender as desigualdades socioespaciais do território fluminense, avaliando até que ponto a escolha destes territórios pode diluir tais disparidades, que é um dos princípios da rede EPT. Foram escolhidas oito cidades, utilizando como critério a população absoluta, com limite de 55.000 pessoas residentes e que representam as sete regiões de governo do estado do Rio de Janeiro onde estão instaladas todas as outras unidades de EPT. O objetivo do estudo é gerar uma reflexão sobre a importância da análise geográfica nas definições dos territórios das EPT’s. A metodologia utilizada é de cunho quali-quantitativo, baseada na análise de dados de órgãos estatísticos e cartográficos, como o Instituto Brasileiro de Geografia e Estatística (IBGE) e a Fundação Centro Estadual de Estatísticas, Pesquisas e Formação de Servidores Públicos do Rio de Janeiro (CEPERJ), bem como a pesquisa bibliográfica pertinente. Espera-se que o texto traga uma visão sobre o papel da rede federal de EPT, principalmente para as cidades do interior do estado, a partir de uma visão espacial.
DEVELOPMENT OF LEARNING EVALUATION TEST ON WORK AND ENERGY MATERIALS FOR GRADE VIII SMP
Authors: Fauziyah Emy , Lina Arifah Fitriyah  
Published: January 2025

Learning evaluation is process to get information to know learning acceptable or not to students. This research aims to develop evaluation questions form multiple choices on work and energy material theoretically and empirically for grade VIII SMP. Development model used ADDIE, consists of stages : Analyze, Design, Development, Implementation, Evaliation. Theoretical validity test obtained from assesment evaluation test from material experts, media experts and practitioners from science teachers. Empirical validity testing obtained from analyzing data from results of testing evaluation test on students includes validity, reliability, level of difficulty, differentiability of questions. Results from validator got score 99,3 % and in very good criteria. Question validity test results 65% the questions valid and 35% the questions invalid. Question reliability test results a calculated r value of 0.774 and in high category. Difficulty level test results of the questions were 20%, 40%, 40% with categories difficult, medium and easy. Different power test results of the questions each received a score of 25% with the criteria very good, good, fair and low. Thus, the evaluation test of work and energy material are worthy of being tested on class VIII students.
Therapeutic potential of Curcuma longa against monkeypox: antioxidant, anti-inflammatory, and computational insights
Authors: Boudou Farouk , Belakredar Amal , Keziz Ahcen , Aissani Linda , Alsaeedi Huda , Cronu David , Bechelany Mikhael , Barhoum Ahmed 
Published: January 2025

BackgroundMonkeypox (Mpox) is a re-emerging zoonotic disease with limited therapeutic options, necessitating the exploration of novel antiviral agents. Curcuma longa (turmeric) is a widely used medicinal plant known for its antioxidant and anti-inflammatory properties, primarily attributed to its bioactive curcuminoids.AimThis study aimed to evaluate the therapeutic potential of C. longa aqueous extract (CAE) against monkeypox through phytochemical characterization, biological assays, and computational analyses.MethodologyPhytochemical analysis, including HPLC, identified key Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin, Tetrahydrocurcumin, Curcuminol, and Ar-curcumene. The DPPH assay and total antioxidant capacity (TAC) were employed to assess antioxidant activity. Anti-inflammatory effects were determined by measuring the inhibition of heat-induced protein denaturation. Molecular docking and molecular dynamics (MD) simulations were performed to evaluate the interactions between curcuminoids and monkeypox virus proteins.ResultsThe aqueous extract of C. longa was prepared via decoction, yielding 7.80% ± 0.81% extract with curcumin as the predominant compound (36.33%). The CAE exhibited strong antioxidant activity with a TAC of 36.55 ± 0.01 µg GAE/g d.w., an IC50 of 0.77 ± 0.04 mg/mL in the DPPH assay, andan EC50 of FRAP of 3.46 ± 0.11 mg/mL. Anti-inflammatory analysis showed 78.88 ± 0.53%inhibition for egg albumin and 90.51 ± 0.29%for BSA. Molecular docking identified demethoxycurcumin (DMC) as the most potent compound, with binding affinities of −8.42 kcal/mol (4QVO), −7.61 kcal/mol (8CEQ), and −7.88 kcal/mol (8QRV). MD simulations confirmed the stability of DMC complexes, with the 4QVO-DMC interaction being the most stable, showing RMSD fluctuations within a range of 0.2–0.6 nm, with an average fluctuation of 0.4 nm, and consistent compactness with Rg values remaining between 1.8 and 2.0 nm, with a fluctuation of only 0.2 nm over 100 ns.DiscussionThe results demonstrate the multifunctional therapeutic potential of C. longa, driven by its potent antioxidant and anti-inflammatory properties. The computational findings suggest that curcuminoids, particularly demethoxycurcumin, could serve as promising antiviral agents against monkeypox. These findings pave the way for further preclinical studies to validate the antiviral efficacy of C. longa bioactives and their potential applications in combating viral infections.
Gut dysbiosis is associated with difficult-to-treat rheumatoid arthritis
Authors: Ruiz-Limón Patricia , Mena-Vázquez Natalia , Moreno-Indias Isabel , Lisbona-Montañez Jose Manuel , Mucientes Arkaitz , Manrique-Arija Sara , Redondo-Rodriguez Rocío , Cano-García Laura , Tinahones Francisco J. , Fernández-Nebro Antonio 
Published: January 2025

BackgroundDifficult-to-treat rheumatoid arthritis (D2T RA) refers to a subset of patients who fail to achieve adequate disease control after the use of two or more biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) with different mechanisms of action, while maintaining active inflammatory disease. This presents a therapeutic challenge and highlights the need to explore contributing factors such as the potential role of the gut microbiota. Therefore, the aim of this study was to analyze the gut microbiota and inflammation in patients with D2T RA in comparison to patients with easy-to-treat RA (E2T RA).ObjectiveTo analyze the gut microbiota and inflammation in patients with D2T RA.MethodsWe performed an observational study of a prospective cohort between 2007 and 2011 and analyzed the gut microbiota. In 2022, we identified 2 extreme patient phenotypes: (1) D2T RA, which was defined as failure of ≥2 biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) (with different mechanisms of action) plus signs of active disease; and (2) easy-to-treat RA (E2T RA), i.e., stable disease managed with a single treatment. The gut microbiota was analyzed using 16S rRNA gene sequencing; bioinformatics analysis was performed using QIIME2, and its functionality was inferred through PICRUSt. We recorded data on clinical findings, inflammation, and cytokines. A Cox multivariate analysis was performed to identify factors related to D2T RA.ResultsThe study population comprised 39 patients: 13 (33%) with D2T RA and 26 (66%) with E2T RA. The families Lachnospiraceae and Pasteurellaceae, and their genera Coprococcus and Haemophilus were more abundant in E2T RA patients, while the genus Megasphaera was more abundant in D2T RA patients. The Firmicutes/Bacteroidetes ratio decreased in D2T RA patients. The metabolic profile of the gut microbiota was characterized by differences in Degradation/Utilization/Assimilation pathway and the Biosynthesis pathway. The factors associated with D2T RA were inflammatory activity according to DAS28-ESR (HR, 2.649; p = 0.013), prednisone (HR, 3.794; p = 0.008), and the Firmicutes/Bacteroidetes ratio (HR, 0.288; p = 0.033).ConclusionThe composition of the gut microbiota of patients with D2T RA differed from that of E2T RA patients, as did the metabolic pathways.
Preexisting hemodialysis and survival outcome in out-of-hospital cardiac arrest patients: Ulsan, South Korea
Authors: Park Song Yi , Kim Sun Hyu , Choi Byungho 
Published: January 2025

BackgroundAlthough the incidence of sudden cardiac death is higher in hemodialysis (HD) patients, whether out-of-hospital cardiac arrest (OHCA) survival outcomes are poorer in this group remains unclear. This study aimed to assess the impact of HD on survival outcomes among adult nontraumatic OHCA patients and to compare these outcomes between HD and non-HD groups.MethodsThis observational cohort study retrospectively analyzed data from adult nontraumatic OHCA patients in Ulsan, South Korea, from January 2017 through December 2022. Multivariable logistic regression analysis was applied to evaluate whether HD was a risk factor for survival in OHCA patients. Survival was compared between the two groups in unadjusted, balanced groups by propensity score matching (PSM) and inverse probability of the treatment weighting (IPWT).ResultsThe study included 2,489 patients (64 HD group and 2,425 non-HD group). Undergoing HD was not significantly associated with any return of spontaneous circulation (ROSC) (adjusted odds ratio [95% confidence interval], p-value, 1.648 [0.934–2.907], 0.085), survival to discharge (1.544 [0.734–3.250], 0.252), or neurological outcomes (0.394 [0.017–9.346], 0.564). There were also no significant differences observed in any ROSC (1.648 [0.934–2.907], 0.085), survival to discharge (1.544 [0.734–3.250], 0.252), or favorable neurological outcome (0.394 [0.017–9.346], 0.564) between the two unadjusted groups. The insignificant survival differences were persistently observed in the PSM group and IPWT group.ConclusionAlthough HD may pose a risk factor for cardiac arrest, our study did not find a significant association with survival outcomes in OHCA patients. Additionally, no notable survival difference was observed between HD and non-HD groups. Therefore, resuscitation efforts in HD patients should not be underestimated.
Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy
Authors: Bruno Francesco , Spadafora Patrizia , Veltri Ida , Cuconati Mario L. , Condino Francesca , Cerantonio Annamaria , De Benedittis Selene , Greco Beatrice M. , Di Palma Gemma , Gallo Olivier , Citrigno Luigi , Qualtieri Antonio , Cundari Maurizio , Cavalcanti Francesca 
Published: January 2025

IntroductionTemporal lobe epilepsy is the most common form of focal epilepsy, often associated with cognitive impairments, particularly in memory functions, and depression. Sex and APOE ε4 genotype play a crucial role in modulating cognitive outcomes and depression in various neurological conditions like Alzheimer's disease. However, the combined effects of APOE genotype and sex on cognitive performance and depression in temporal lobe epilepsy have not been previously investigated.ObjectiveThis study aims to (i) identify impaired cognitive performance and clinically relevant depression; (ii) explore the interaction between sex and APOE ε4 genotype on cognitive performance and depression in individuals with temporal lobe epilepsy.MethodsWe used a comprehensive battery of neuropsychological tests to assess domains such as learning and memory, attention, executive functions, language, and visuo-spatial constructional skills and the Hamilton Depression Rating Scale. We also performed APOE genotyping to assess its role in the study. The final sample was composed by fifty-four patients (53.7% female). Cognitive performance and depression were analyzed using normative cut-off scores. To examine the main effects and interactions of sex and APOE ε4 carrier status on neuropsychological test scores and the Hamilton Depression Rating Scale, we also conducted a two-way Analysis of Variance (ANOVA).ResultsFemale APOE ε4 carriers compared to normative cut-offs, exhibited poor performance on multiple test scores, including the MMSE, The Rey Auditory Verbal Learning Test (immediate and delayed recall), The Corsi Block-Tapping Task, The Verbal Fluency Test, The Raven's Standard Progressive Matrices and The Pentagon-copying Test. Males showed impairment only in visuo-spatial short-term memory. ANOVA analysis revealed significant main effects of APOE ε4 status and sex on the MMSE, The Rey Auditory Verbal Learning Test, The Verbal Fluency, The Raven's Standard Progressive Matrices and The Pentagon-copying Test scores. Specifically, female APOE ε4 carriers performed consistently worse than other groups on many tasks. For depression, only an effect of sex emerged. Females scored higher besides APOE genotype.ConclusionsThese findings underscore the importance of considering both sex and APOE genotype when assessing cognitive performance in patients with temporal lobe epilepsy. The significant cognitive deficits we observed among females carrying the APOE ε4 allele highlight previously unexplored genetic and sex-related influences on cognition. This has potential implications for personalized therapeutic strategies, emphasizing the need for targeted assessment and intervention.
Severe cutaneous drug toxicity following disitamab vedotin treatment for metastatic gastric cancer: a case report
Authors: Luping Zhao , Zhen Cheng , Piaopiao Li 
Published: January 2025

BackgroundThis study reports a case of severe cutaneous toxicity in a patient with metastatic gastric cancer induced by disitamab vedotin, emphasizing the need for careful monitoring and management in such treatments.Case presentationA 71-year-old female was admitted to hospital complaining of serious rashes following the first cycle of disitamab vedotin regimen for metastatic gastric cancer. The doctor diagnosedtoxic epidermal necrolysis (TEN) induced by the drug. The patient received high-dose methylprednisolone due to the side effects. This resulted in a gradual improvement of symptoms.ConclusionDuring the use of disitamab vedotin, patients need to be monitored for severe skin toxicity.
Knowledge about diabetes in Malmö prior to initiation of “Cities Changing Diabetes”
Authors: Annersten Gershater Magdalena , Rämgård Margareta , Holmberg Cecilia Nagorny , Grahn Mathias , Zdravkovic Slobodan 
Published: January 2025

AimTo identify existing public knowledge regarding diabetes and diabetes-related services offered to persons living with diabetes in the City of Malmö.MethodsA literature review of City of Malmö’s website, public statistics, School health documentation, job databases, education programs, local newspaper, Swedish National Diabetes Register, and PubMed was performed in 2020.ResultsWe identified political decisions about diabetes nurses in home care, financing a project about diabetes complications, and funding support in schools for designated children. Schools had no registrations of diagnoses. Diabetes was common among pregnant women. The local newspaper discussed children and older people with diabetes asking for increased support. Job listings did not require diabetes-relevant competencies. Curricula for nursing assistants did not mention diabetes. National Diabetes Register reported 16,658 persons in Malmö. Three articles were identified in PubMed.ConclusionPublic documents in Malmö did not mention diabetes despite being responsible for caring for persons with diabetes.