bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subtypes of Insomnia Disorder Identified by Cortical Morphometric Similarity Network
Authors: Zhang Haobo , Sun Haonan , Li Jiaqi , Lei Xu 
Published: January 2025

ABSTRACTInsomnia disorder (ID) is a highly heterogeneous psychiatric disease, and the use of neuroanatomical data to objectively define biological subtypes is essential. We aimed to examine the neuroanatomical subtypes of ID by morphometric similarity network (MSN) and the association between MSN changes and specific transcriptional expression patterns. We recruited 144 IDs and 124 healthy controls (HC). We performed heterogeneity through discriminant analysis (HYDRA) and identified subtypes within the MSN strength. Differences in MSN between subtypes and HC were compared, and clinical behavioral differences were compared between subtypes. In addition, we investigated the association between MSN changes and brain gene expression in different ID subtypes using partial least squares regression to assess genetic commonalities in psychiatric disorders and further performed functional enrichment analyses. Two distinct subtypes of ID were identified, each exhibiting different MSN changes compared to HC. Furthermore, subtype 1 is characterized by objective short sleep, impaired cognitive function, and some relationships with major depressive disorder and autism spectrum disorder (ASD). In contrast, subtype 2 has normal objective sleep duration but subjectively reports poor sleep and is only related to ASD. The pathogenesis of subtype 1 may be related to genes that regulate sleep rhythms and sleep–wake cycles. In contrast, subtype 2 is more due to adverse emotion perception and regulation. Overall, these findings provide insights into the neuroanatomical subtypes of ID, elucidating the relationships between structural and molecular aspects of the relevant subtypes.
Trends in Investigations for Suspected Head and Neck Carcinoma of the Unknown Primary: A HNCIG and IFHNOS International Survey of Practice
Authors: Williamson Andrew , Nankivell Paul , Abou‐Foul Ahmad K. , Ahmed Mohamed , Mehanna Hisham ,   HNCIG and IFHNOS CUP programme
Published: January 2025

ABSTRACTBackgroundThe aim of this clinical survey was to assess variations in head and neck squamous cell carcinoma from an unknown primary (HNSCCUP) diagnostic practices across international centers.MethodsClinical practice survey of experts nominated by Head and Neck Cancer International Group (HNCIG) and International Federation of Head and Neck Oncologic Societies (IFHNOS).ResultsResponses were received from 48/49 (97.9%) participants. Outpatient laryngoscopy, CT, and 18‐FDG‐PETCT were used always or most of the time by 81.3%, 77.1%, and 79.2%, but only 50% regularly used MRI. Unilateral and bilateral tonsillectomy were frequently performed in 41.6% and 27.1% of unilateral nodal disease, and in 18.8% and 52.1% for bilateral disease. Ipsilateral Tongue Base Mucosectomy (TBM) was used always or most of the time in 12.5% of unilateral and 6.3% of bilateral HNSCCUP. Bilateral TBM was used in 10.4% for unilateral and 22.9% for bilateral cancers.ConclusionsWhile there is broad agreement regarding examination and cross‐sectional imaging, there are considerable differences in the surgical strategies used to identify occult primaries.
Anomaly Detection System for Users and Devices Involved in Internet of Things Integrated Cloud Applications Using Machine Algorithms
Authors: Mirdula S. , Roopa M. 
Published: January 2025

ABSTRACTRecently, due to their application nature, devices in the Internet of Things (IoT) networks also need to be involved in the cloud. IoT devices generally work on top of the Internet, whereas today, the Internet is called a cloud because it provides an uncountable number of services to the public. Software, Platform, Infrastructure, and Service are the base classes of cloud services that support IoT devices. It is well known that the security level of the cloud is deficient because anyone can access it from anywhere at any strategy. Like the cloud, IoT networks also permit any device to join anytime from anywhere. This vulnerability of IoT networks is a cause for concern, and various conventional and optimisation methods have proposed multiple algorithms for increasing the IoT Cloud's security level, which have been developed for particular applications. This problem is solved by thoroughly examining the IoT devices, user information, and meta‐information to detect anomalies in the cloud applications, ensuring the validity and effectiveness of our proposed solution. The IoT network is analyzed using an NS2 simulator, and machine learning algorithms carry out the data analytics to select the best one that outperforms the others in anomaly detection. The machine learning algorithms were implemented in Python and experimented with it to check their efficiency.
Leveraging pharmacists' scope of practice to improve access to gender‐affirming care: A scoping review
Authors: Gillis Sophie , Walter Robyn , Wilby Kyle John 
Published: January 2025

AbstractBackgroundTransgender and gender‐diverse (TGD) individuals experience health inequities at a substantially higher rate than their cisgender counterparts. Gender‐affirming care (GAC) is a lifesaving measure that encompasses a range of social, psychological, behavioral, and medical interventions designed to affirm an individual's gender identity. Access to GAC is limited worldwide and pharmacists may be optimally situated to bridge this gap.ObjectivesTo determine strategies to improve access to GAC within community pharmacists' scope of practice for TGD patients.MethodsThis was a scoping review of published literature. Three databases (PubMed, Embase, and CINAHL) were searched and supplemented with a manual citation to yield 324 articles. Articles were included if they described or evaluated GAC services performed by pharmacists. Screening and extraction were conducted independently by two reviewers. Extracted data was mapped into six categories (prescribing, monitoring, patient education and counseling, healthcare advocacy, interprofessional and collaborative care, and non‐pharmacological), which were identified during the extraction process to represent GAC initiatives.ResultsTwenty‐one articles met the inclusion criteria from the 324 articles initially screened. Most articles were published in the United States (n = 17). More than half of the articles described prescribing (n = 12), monitoring (n = 15), and patient education and counseling (n = 17). Healthcare advocacy was mentioned in 9 articles, with interprofessional and collaborative care being mentioned in 8 articles. Non‐pharmacological care was the least mentioned among the six categories (n = 2).ConclusionsCurrent literature shows that pharmacists' scope of practice can be leveraged to provide GAC through prescribing medications, monitoring therapy, educating and counseling patients, advocating for TGD individuals within the healthcare system, providing collaborative care, and through the provision of non‐pharmacological GAC options.
Chitosan/Alginate‐Based Hydrogel Loaded With VE‐Cadherin/FGF as Scaffolds for Wound Repair in Different Degrees of Skin Burns
Authors: Liu Sainan , Wei Lai , Huang Jinquan , Luo Jiayan , Weng Yajun , Chen Junying 
Published: January 2025

ABSTRACTBurns are complex traumatic injuries that lead to severe physical and psychological problems due to the prolonged healing period and resulting physical scars. Owing to their versatility, hydrogels can be loaded with various functional factors, making them promising wound dressings. However, many hydrogel dressings cannot support cell survival for a long time, thereby delaying the process of tissue repair. Herein, based on chitosan (CS)/alginate (SA)/poly(ethylene glycol) diacrylate (PEGDA), a basic hydrogel with hemostasis and antibacterial properties was prepared, and loaded with vascular endothelial cadherin (VE‐cadherin) and fibroblast growth factors (FGF) to promote the co‐culture of various skin cells, suitable for treating various skin injury types: (1) Construct a three‐dimensional microenvironment conducive to the release of drugs and factors using natural biological macromolecules CS/SA. (2) Promote the cell growth by loading growth factors. (3) Establish skin burn models of different degrees and observe the repair process. From the results, the 3D microenvironment provided by hydrogel could support the active growth of cells for 12 days. Furthermore, deep burns with full‐thickness skin were substantially repaired within about 24 days. Collectively, CS/SA hydrogel containing VE‐cadherin and FGF can promote tissue healing in wounds with necrotic tissue, making it an ideal candidate for burn treatment.
Stem fixation techniques in revision total knee arthroplasty: A systematic review and meta‐analysis
Authors: Onorato Francesco , Giai Via Riccardo , Bosco Francesco , Lavia Alessandro Dario , Barberis Luca , Capella Marcello , Massè Alessandro , Risitano Salvatore 
Published: January 2025

AbstractPurposeThis systematic review and meta‐analysis aimed to compare the clinical and radiological outcomes of patients undergoing revision total knee arthroplasty (rTKA) using uncemented press‐fit stems (hybrid fixation) versus cemented stems (cemented fixation). It is also examined whether cemented fixation offers any superiority over hybrid fixation regarding implant survival, clinical function, imaging analysis and complication rates.MethodsFollowing the PRISMA guidelines, a systematic review and meta‐analysis were conducted on five databases (Pubmed, Scopus, Embase, Medline and Cochrane). Articles were evaluated according to levels of evidence (LoE). Retrospective studies were analysed with risk of bias in nonrandomised studies of interventions (Robins‐I) and randomised controlled trials with risk of bias 2 (RoB‐2). This review was registered in the International Prospective Register of Systematic Reviews database. Meta‐analysis was performed using R software, with p < 0.05 considered statistically significant.ResultsData from 12 comparative studies with 1303 patients (1352 rTKAs) were analysed. Survival rates of hybrid and cemented fixations were comparable, with a significant trend favouring hybrid fixation (p = 0.04). Infection and aseptic loosening were the most common causes of failure. Radiographic failure rates showed no significant differences between fixation methods (p = 0.4). Meta‐analysis indicated better results with hybrid fixation, although not statistically significant (KSS functional p = 0.15; KSS clinical p = 0.5). High heterogeneity was observed due to variations in patient characteristics and surgical strategies.ConclusionBoth hybrid and cemented fixation techniques achieve satisfactory clinical results in rTKA, with hybrid fixation demonstrating an overall lower failure rate. The choice of fixation method must be tailored to individual patient characteristics and surgical considerations. Further high‐quality randomised trials are needed to refine these results and optimise fixation strategies to improve patient outcomes.Level of EvidenceLevel IV.
Telocinobufagin suppresses malignant metastasis of undifferentiated thyroid carcinoma via modulation of the LARP1‐mTOR pathway
Authors: Qiang Li‐Zhi , Fang Shi‐Zhi 
Published: January 2025

AbstractMetastasis is the trigger of death in anaplastic thyroid cancer (ATC) patients, yet the specific mechanisms at play are still largely enigmatic. While the involvement of LARP1 in the metastatic process of various cancers has been documented, there is a noticeable gap in the literature regarding its potential influence on ATC metastasis. Molecular studies probed LARP1 expression within ATC cells, with subsequent in vitro experiments examining the effects of LARP1 on ATC cell metastasis and the mTOR signaling cascade. A suite of assays, including colony formation, scratch wound healing, transwell invasion, and cell adhesion, was used to assess cell growth, movement, invasion, and attachment. Western Blot determined the expression levels of epithelial–mesenchymal transition (EMT) markers (E‐cadherin, Vimentin, N‐cadherin) and proteins implicated in metastasis (MMP‐2, MMP‐9), along with mTOR and p‐mTOR. The affinity of Telocinobufagin (TBG) from Yuanhua Toad Essence for LARP1 was investigated through molecular docking, with CETSA assays providing subsequent validation. Further cellular experiments substantiated the influence of TBG on ATC cell metastasis and modulation in the mTOR pathway. LARP1 levels were heightened in ATC cells, and its depletion effectively curbs their proliferative, migratory, invasive, and adhesive activities. With LARP1 knockdown, we also observed that the onset of EMT and metastatic processes was thwarted, as was the mTOR pathway. Subsequent research has uncovered that TBG formed a physical complex with LARP1, allowing it to target and suppress the mTOR pathway, thus preventing the metastasis of ATC. The simultaneous overexpression of LARP1, however, lessened the ability of TBG to inhibit ATC metastasis. This study highlights the importance of TBG binding to LARP1 in the mediation of the mTOR signaling pathway, a key process in the inhibition of ATC cell metastasis. This discovery introduces a new target for the diagnosis of ATC and enlightens the consideration of TBG as a treatment for ATC metastasis.
MASCN Vapor‐Assisted Fabrication of Compact and Large‐Grain MAPbI3 Polycrystalline Wafer for X‐Ray Detection and Imaging
Authors: Liu Dan , Liao Feiyi , Di Haipeng , Li Haibin , Tie Shujie , Song Jiangfeng , Lei Lin , Chen Changan 
Published: January 2025

AbstractLead halide perovskite wafers, which have adjustable size and thickness, are promising for the tailored fabrication of X‐ray detectors. However, common voids and grain boundaries, acting as carrier traps in polycrystalline wafers, present a major challenge to achieving optimal optoelectronic properties. Herein, an innovative approach is adopted by introducing methylammonium thiocyanate (MASCN) vapor into the hot‐pressing environment of MAPbI3 wafers, promoting perovskite grain merging and growth. The resulting compact wafers with larger crystal grains display an extended average carrier lifetime (τavg) of 31.61 ns, a high ion activation energy (Ea) of 0.47 eV, a reduced dark current drift (Idrift) of 4.11 × 10−4 nA cm−1 s−1 V−1, and an improved mobility‐lifetime product (µτ) of 8.26 × 10−4 cm2 V−1. These optimized MAPbI3 wafer‐based detectors achieve a high sensitivity of 16611 µC Gyair−1 cm−2, a low detection limit (LoD) of 47.5 nGyair s−1, and robust operational stability in X‐ray detection. Furthermore, these detectors exhibit excellent X‐ray imaging capability, achieving a high spatial resolution of 5.64 lp mm−1. Therefore, the deployment of volatile thiocyanate salt during hot pressing provides a novel strategy for engineering high‐quality polycrystalline perovskite wafers, propelling forward the field of X‐ray detection.
Treatment of Acne With a 1726 nm Laser, Air Cooling, and Real‐Time Temperature Monitoring, Software‐Assisted Power Adjustment to Achieve a Temperature Endpoint With Selective Sebaceous Gland Photothermolysis
Authors: Tanghetti Emil A. , Sierra Rafael , Estes Michael , Eck Aubrey , Intintoli Alfred , Hofvander Henrik , Cohen Joel L. , Friedmann Daniel P. , Goldman Mitchel P. , Pomerantz Hyemin , Wang Jordan V. , Geronemus Roy G. , Anderson R. Rox , Sakamoto Fernanda H. 
Published: January 2025

ABSTRACTObjectivesThis work highlights the methods used to develop a multi‐pulse 1726 nm laser system combined with bulk air‐cooling for selective sebaceous gland (SG) photothermolysis using thermal imaging and software algorithms. This approach enables treating to a desired tissue temperature and depth to provide a safe, effective, reproducible, and durable treatment of acne.MethodsWe designed and built a 1726 nm laser system with a 40 W maximum power output, a highly controlled air‐cooling device, and a thermal camera in the handpiece, which permits real‐time temperature monitoring of the epidermis. IRB‐approved safety and efficacy trials demonstrated SG damage at depth, resulting in safe, efficacious, and durable clinical outcomes. Bioheat transfer and light transport modeling confirmed that the pulsing protocols could produce therapeutic temperatures at various SG depths, while protecting the epidermis and dermis with bulk air‐cooling. Similarly, we employed clinical observations and photothermal modeling to identify pain mitigation opportunities while maintaining therapeutic efficacy. Biopsies were subsequently taken for histological evaluation.ResultsClinical and histological data, confirmed with modeling, demonstrated that multi‐pulse laser delivery with bulk air‐cooling selectively increased SG temperature compared to surrounding dermis and at depths unachievable by a single pulse. Subjects showed an average 71% ILC reduction at 3 months posttreatment. We identified two different pulsing protocols with similar selective photothermolysis (SP) of the SG with very different pain responses. Thus, changing the pulsing protocols allowed for pain mitigation and eliminated the need for injectable anesthetic. Histology confirmed the selective damaging of the SG at depth and the preservation of the surrounding dermis and the epidermis.ConclusionsThe multi‐pulse 1726 nm laser with bulk air‐cooling, thermal monitoring, treat‐to‐temperature (and depth) control, and a unique pulsing protocol, is capable of selectively damaging SGs at depth without damage to the surrounding dermis or the epidermis. The system offers two different protocols that were developed with different levels of discomfort allowing for two different methods for pain mitigation (injectable vs. topical anesthesia).
Exact Boundary Controllability for a System of Coupled Wave Equations in Noncylindrical Domains
Authors: Nunes Ruikson. S. O. 
Published: January 2025

ABSTRACTThis paper concerns to study an exact boundary controllability problem for a system of coupled wave equations in domains with moving boundaries. Such systems model the vibrations of identical flexible bodies coupled in parallel by means of an elastic layer where their boundaries present a bounded movement. The control is square integrable and acts on all moving boundary, and it is obtained by means of conormal derivative of the solution. The controllability method used here is that one established by D. L. Russell.
Informing the Development of Telehealth Education in Physiotherapy Programs. Assessments and Interventions for Individuals Accessing Physiotherapy Care via Synchronous Telehealth. A Scoping Review
Authors: Davies Luke M. , Lawton Vidya , Bevan Rebecca , Mestousis Mikayla , Pacey Verity 
Published: January 2025

ABSTRACTBackgroundIn order to develop contemporary telehealth curricula for entry‐to‐practice physiotherapy programs that develop the capabilities required to practice telehealth, it is important to evaluate the delivery of telehealth practices within the physiotherapy profession.ObjectiveTo assess the current literature to (i) determine what types of assessments and interventions have been delivered via synchronous forms of telehealth (videoconferencing and telephone) by physiotherapists (ii) determine which platforms were used for service delivery and which practice areas have delivered synchronous telehealth physiotherapy assessments and interventions.DesignScoping review adhering to Joanna Briggs Institute guidelines. Three electronic databases (Medline, Embase, and CINAHL) were searched for articles involving physiotherapists using synchronous forms of telehealth (videoconferencing/telephone) to deliver assessments and/or interventions.Study SelectionArticles were included if they related to physiotherapists using synchronous forms of telehealth (videoconferencing and/or telephone) to deliver assessments and/or interventions.Data SynthesisA narrative synthesis was conducted.ResultsFrom 2748 records, 134 studies were included. Standardised assessments (e.g. subjective assessments, range of motion, functional assessment) were the most commonly (82%) delivered. Most interventions delivered were exercise (82%), followed by education (27%). Freely available synchronous videoconferencing platforms including Zoom (n = 30, 34%), WhatsApp (n = 10, 11%), and Skype (n = 9, 10%) were commonly used. Telehealth‐delivered physiotherapy assessment and interventions were primarily utilised in musculoskeletal (33%), neurological (23%) and respiratory (14%) practice areas.ConclusionThe diverse use of physiotherapy telehealth‐delivered assessments and interventions across varied clinical practice settings and patient populations highlights the importance of preparing future physiotherapists with telehealth skills fit for contemporary practice.
Quality of Non‐Surgical and Non‐Pharmacological Knee Osteoarthritis Care in the Maritimes
Authors: Budarick Aleksandra R. , Hubley‐Kozey Cheryl L. , Li Linda C. , Theou Olga , Stanish William D. , Moyer Rebecca F. 
Published: January 2025

ABSTRACTObjectivesTo evaluate the quality and types of care individuals with mild‐to‐moderate knee osteoarthritis receive in the Canadian Maritime provinces, and determine associations with demographic, social, and patient‐reported factors.MethodsIndividuals with knee osteoarthritis were invited to complete a healthcare quality survey based on the British Columbia Osteoarthritis (BC OA) survey. The cross‐sectional descriptive observational survey assessed four healthcare quality indicators: advice to exercise, advice to lose weight, assessment of ambulatory function, and assessment of non‐ambulatory function. Pass‐rates were calculated overall and for each quality indicator. Binary logistic regressions determined associations between quality indicators and demographic, social, and patient‐reported outcomes. Patient‐reported use of exercise and diet as arthritis treatments were added to the quality indicator eligibility criteria as a sensitivity analysis.ResultsParticipants (n = 241) had a mean age of 67 (7) years, body mass index of 30.7 (7.5) kg/m2 and were 77% female. The overall pass rate was 42.9% using the BC OA criteria, and 49.3% in the sensitivity analysis. Individual quality indicator pass‐rates ranged from 4.3% for non‐ambulatory function to 85.7% for ambulatory function assessments. The sensitivity analysis increased pass‐rates for advice to exercise (61.9%–69.3%) and advice to lose weight (27.9%–35.1%). Pass‐rates were not driven by demographic, social, or patient‐reported factors.ConclusionsOver half of individuals with mild‐to‐moderate knee osteoarthritis did not receive recommended core treatments in the Maritimes, highlighting a need to improve care for this patient group. Quality indicators should be routinely evaluated to determine whether clinical care aligns with best practice guidelines.