bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distrofia Muscular de Duchenne/Becker
Authors: Guerra-Torres Mariana , Suárez-Obando Fernando , García-Roblesa Reggie , Ayala-Ramírez Paola 
Published: July 2023

Antecedentes: las distrofias musculares son un tipo de miopatías, en su mayoría de etiología genética, caracterizadas por generar debilidad muscular progresiva. Dentro de las distrofias musculares, la Distrofia Muscular de Duchenne/Becker (DMD/B) es la más frecuente. Se produce por variaciones genéticas en el gen DMD, conduciendo a la ausencia o deficiencia de la proteína distrofina.
Tema: la distrofina es una proteína que hace parte de un complejo. En ausencia de la proteína, se generan unos mecanismos a nivel intracelular que conducen a la degeneración de la fibra muscular. Tiene un espectro clínico variable, siendo la forma menos severa y de inicio más tardío considerada como Distrofia Muscular de Becker en comparación con la Distrofia Muscular de Duchenne de inicio temprano y de mayor severidad. Sin embargo, en algunos casos no es tan fácil su clasificación de esta manera. La DMD/B no tiene un tratamiento curativo y en la actualidad los tratamientos son enfocados hacia el alivio sintomático y manejo de complicaciones. Se han desarrollado recientemente nuevas terapias que apuntan fundamentalmente a la corrección del defecto molecular en el gen DMD/B al inducir la expresión de una proteína funcional o semifuncional.
Conclusiones: la DMD/B es el tipo de distrofia muscular más frecuente y más severa, que genera gran discapacidad y con un pronóstico de vida corto. El diagnóstico temprano es fundamental para la instauración del manejo, que debe ser multidisciplinario, con el objetivo de retrasar el inicio de la pérdida de funcionalidad muscular y pérdida de la marcha.
Barriers to Basic School Teachers’ Implementation of Formative Assessment in the Cape Coast Metropolis of Ghana
Authors: Asare Eric , Afriyie Elizabeth 
Published: July 2023

Abstract
Despite the identified benefits of formative assessment to teaching and learning, its implementation in the classroom remains a significant challenge to teachers. This has widened the gap between the theory and practice of formative assessment in the classroom to enhance students’ learning. This study investigated the potential resource-related factors that affect basic teachers’ adoption of formative assessment in their classrooms. A descriptive survey design with a multistage sampling procedure was employed to select 300 teachers from the six circuits in the Cape Coast Metropolis of Ghana. Data gathered were analyzed using descriptive (mean values, SD) and inferential statistics (two-way ANOVA). Time, workload, overcrowded curriculum, class size, and the number of lessons were reported as barriers to the effective implementation of formative assessment. Findings also revealed no statistically significant interaction effect of gender and grade level on the resource-related barriers. Moreover, grade level and gender had no statistically significant main effects with respect to the resource-related barriers. Recommendations and implications for policy, practice, and future research are discussed.
Nanoscale molecular reactions in microbiological medicines in modern medical applications
Authors: Shesayar Radjarejesri , Agarwal Amit , Taqui Syed Noeman , Natarajan Yuvaraj , Rustagi Sarvesh , Bharti Sweety , Trehan Anchal , Sivasubramanian Kanagasabapathy , Muruganandham Moorthy , Velmurugan Palanivel , Arumugam Natarajan , Almansour Abdulrahman I. , Kumar Raju Suresh , Sivakumar Subpiramaniyam 
Published: July 2023

Abstract
Everything around us is made up of atoms and molecules. The properties of quantum atoms are sought to understand the behavior of a particular object. But with the advent of research, it was discovered that there is a quantity smaller than the molecular size. The nanoscale measures a fraction of a billionth of a meter. The atom of an object measures 0.1 nm. Since atoms are the building blocks of matter, at the nanoscale one can combine these atoms to create new materials. The proposed model displays the properties of these nano-scale elements in modern medical applications. The nano-scale research of matter is fascinating because it is the basic phase in which atoms are held together. Therefore, by manipulating material at this level, one can create many different types of objects. This proposed model calculates the operation requirements and expects the results. Based on the operational requirements, the proposed model provides the suggestions. This will be helpful for the medical researchers to identify the proper medical treatments based on the microbiological requirements.
Resilience Theory, Human Agency, and Political Archaeology: A RT Revised Model for the Understanding of the Late Bronze – Iron Age Transition in the Post-Hittite World
Authors: d’Alfonso Lorenzo 
Published: July 2023

Abstract
Over the last twenty years, due to the growing concern with the human-environment relationship in the contemporary world as well as in the study of the ancient world, Resilience Theory (RT) has been adopted and adapted from the study of ecosystems to the study of stress dynamics within socio-political systems. The adaptation is indebted to the seminal work of Holling and Gunderson (2002. “Resilience and Adaptive Cycles.” In Panarchy: Understanding Transformations in Human and Natural Systems, edited by L. H. Gunderson, and C. S. Holling, 25–62. Washington, DC: Island Press), reviewed recently for application in archaeology in a volume edited by Faulseit (2016b. “Collapse, Resilience, and Transformation in Complex Societies: Modeling Trends and Understanding Diversity.” In Beyond Collapse: Archaeological Perspectives on Resilience, Revitalization, and Transformation in Complex Societies, edited by R. K. Faulseit, 3–26. Visiting Scholar Conference Volumes. Carbondale, IL: Southern Illinois University Press). While social scientists, anthropologists and archaeologists interested in system theories have welcomed this new interpretative tool for the study of rapid change in socio-political systems, RT has been considered unsatisfactory and substantially rejected by several scholars in the humanities because of the lack of freedom and intention assigned to human actors. After a short presentation of these premises, the paper seeks to affirm a different model for a social cycle of formation-growth-maturity-release, in which resilience is only one among a number of possible outcomes of the release phase, depending on the collective/political choice/orientation of a society. Put simply, the new model suggests reorganization and transformation as two alternative outcomes alternative to resilience. The model is applied to the case study of the Late Bronze Age (LBA) – Early Iron Age (EIA) transition in Anatolia and north Syria, corresponding to the time of the fall and aftermath of the Hittite empire. It will be shown that the adoption of the model offers a productive interpretive key to understand different outcomes in the new fragmented reality.
Kierkegaards Begriff Angst als „gottesfürchtige Satire“
Authors: Neuber Simone 
Published: July 2023

Abstract
Kierkegaard՚s The Concept of Anxiety deserves to be treated as a central text on sin, but not because it introduces an ingenious intermediate psychological determination that helps to approach an explanation of the „Fall.“ Its real relevance lies in the way the text enacts the noetic effects of sin through a theoretical reflection on the possibility of sin. This essay unfolds this thesis and assigns a central hermeneutical role to Caput 4.
Is There a Suspension of Subjectivity?
Authors: Brorson Mikael 
Published: July 2023

Abstract
This article examines the Kierkegaard reception of the Danish theologians K. Olesen Larsen and Johannes Sløk, who both understood Kierkegaard as attempting to radically subvert the freedom of the human being. Initially, I show how current Kierkegaard research on the question of subjectivity, freedom and indirect communication differs from the readings of Olesen Larsen and Sløk. Subsequently, and in contrast to this, Olesen Larsen’s somewhat ambivalent attempt to read Kierkegaard as undermining human freedom is presented. Third, I show how Sløk arrives at a somewhat similar result, though in a more coherent way. In conclusion, the article offers a brief discussion on the plausibility of this interpretation.
“Forgiveness is forgiveness:” Kierkegaard’s Spiritual Acoustics
Authors: Esparza Daniel R. 
Published: July 2023

Abstract
Kierkegaard’s distinction of chatter from silence gives forgiveness a linguistic spin. How can forgiveness be spoken? Is forgiveness something to be said and heard? Is saying it aloud saying too much, or too little? What is said when (and if) forgiveness is said? Should forgiveness be chatted away, or reserved in silence? For Kierkegaard, the answer(s) is (are) neither/nor: forgiveness can only be said indirectly, kept (almost) indistinguishable from resentment or indifference, as if discarded in the face of offense—if it is to happen.
Fast vergessen: Die Nachwirkungen von Kierkegaards Kulturkritik im Krisendiskurs der dänischen Nachkriegszeit
Authors: Becker-Lindenthal Hjördis 
Published: July 2023

Abstract
The article examines the explicit and implicit role that Kierkegaard played in the cultural criticism developed in the literary circle of the Danish journal Heretica (1948 – 1954). The cultural criticism of Kierkegaard and eminent Danish post-war authors (Martin A. Hansen, Vilhem Grønbech, Bjørn Poulsen, Tage Skou-Hansen and Ole Wivel) is contextualized in the tradition of Western cultural criticism. An analysis of central concepts such as crisis, rationality, spirit and reflection as well as alienation, individuality and community, demonstrates the original contributions these authors make to the modern understanding of culture. Furthermore, the article addresses the reservations that some of the Heretica- authors had towards Kierkegaard. The accusation of solipsism, however, turns out to be unwarranted. Rather, it becomes clear that Kierkegaard’s emphasis on the individual, like the post-war authors’ critique of fascism, is directed against the power of the masses and the increasing bureaucratization of life. Finally, Kierkegaard as well as the 20th century authors depict neighbor love as decisive for a post-restitutive, forward-oriented way out of a severe cultural crisis.
Collagen treatment of complex anorectal fistula: 3 years follow-up
Authors: Maternini Matteo , Guttadauro Angelo , Avella Pasquale , Buondonno Antonio , Mascagni Domenico , Milito Giovanni , Stuto Angelo , Renzi Adolfo , Rennis Maria , Bottini Corrado , Quarto Gennaro , Nudo Raffaele , Del Re Luca , Amato Bruno , Gabrielli Francesco 
Published: July 2023

Abstract
Fistula in ano is a common anorectal disease in adults. Currently, surgery remains the definitive therapeutic approach, but in some cases, it can lead to serious complications as faecal or gas incontinence. Therefore, sphincter sparing treatments should be considered for complex fistulas. One of the sphincteric preserving treatment is the filling with a dermal extract commonly called “collagen glue” as Salvecoll-E® gel. This is a multicentric, prospective, observational study on the use of Salvecoll-E® gel in treatment of complex anal fistulas. We treated 70 patients from May 2016 to May 2017. In the first phase, we debrided the fistula tract using a loose seton kept for 4–6 weeks. In the second phase, the seton was removed and the fistula tract was filled with Salvecoll-E® gel. In this article, we report results at 36 months of follow-up. Fifty patients (71.4%) had completely healed fistula within 36 months of follow-up. Twenty-eight patients (28.2%) had recurrences. Among these failures, 65% were within 6 months. All low transphincteric fistulas healed. Recurrences occurred only in median and high transphincteric fistulas. No patient had a worsening of continence status measured with Cleveland Clinic Florida Incontinence Severity score. Salvecoll-E® gel is a recent finding among sphincter-sparing treatments. In this study, we demonstrate that it is a safe option in the treatment of complex fistulas. Final results are satisfactory and in line with the best results published in literature among mini-invasive treatments.
Realizing depth measurement and edge detection based on a single metasurface
Authors: Yang Siwen , Wei Qunshuo , Zhao Ruizhe , Li Xin , Zhang Xue , Li Yao , Li Junjie , Jing Xiaoli , Li Xiaowei , Wang Yongtian , Huang Lingling 
Published: July 2023

Abstract
How to simultaneously obtain the depth, edge, and other light information of the scene to accurately perceive the physical world is an important issue for imaging systems. However, such tasks usually require bulky optical components and active illumination methods. Here, we design and experimentally validate a single geometric metasurface that can achieve depth measurement or edge detection under incoherent or coherent light respectively. Double helix point source function is utilized, and three verification experiments are carried out, including double-helix beam calibration, 2D object and 3D object detection, respectively. Additionally, two-dimensional edge detection can also be achieved. This compact imaging system can enable new applications in various fields, from machine vision to microscopy.
Photocatalytic degradation of dyes in aqueous media by gum shellac stabilized selenium nanoparticles
Authors: Iqbal Zartasha , Imran Muhammad , Latif Shoomaila , Nazir Arif , Ibrahim Sobhy M. , Ahmad Iftikhar , Iqbal Munawar , Iqbal Shahid 
Published: July 2023

Abstract
The present work outlines the successful synthesis of selenium nanoparticles (Se NPs) stabilized with gum shellac (GS) and their use as photocatalyst for the enhanced degradation of dyes. Se NPs were synthesized by a simple and cost effective chemical reduction method using selenious acid, GS and sodium borohydride. Gum shellac was used as stabilizing agent. The orange red gum shellac-selenium nanoparticles (GS–Se NPs) were characterized by UV–Vis spectroscopy, Fourier transform infra-red (FTIR), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The morphology of these particles appeared to be uniform and spherical as observed in SEM images. Energy dispersive X-ray spectroscopic profile showed the presence of elemental selenium, carbon and oxygen. The synthesized GS–Se NPs were investigated for their photo-catalytic efficiency towards degradation of methylene blue (MB) and methyl orange (MO) dye in aqueous media. Absorbance was measured at λ
max 665 nm and 455 nm for MB and MO, respectively. Maximum degradation of MB in-comparison with MO obtained at 50 mg/L were 81.72 % and 71.42 % respectively. A very slow degradation rate was observed for the MO and MB in the absence of synthesized photocatalyst whereas greater percentage degradation was observed for the GS–Se NPs.
Ceramic fragments in the Sanctuary of Artemis: permanence of the feminine cult in Archaic Thasos
Authors: Da Hora Juliana Figueira 
Published: July 2023

The purpose of this article is to shed light part of the contextual methodological analysis of ceramics found in Artemísion of Thasos, an island located in the North of the Aegeus. Thasos was founded in the 7th century BC by the island of Paros, according to written sources. The sanctuary of Artemis is an important religious marker for understanding the urban expansion of the city, as well as the dynamics of female worship based on Greek Cycladic, Thracian, local and regional elements. The data collected allowed us to understand how materiality reveals issues about feminine and religious aspects based on the ceramic shards found in the sectorial contexts of Artemision of Thasos.

Abstract:
The aim of this article is to bring to light part of the contextual methodological analysis of the Black Figures lekane (Archaic Period) found in the Artemísion of Thassos, an island located in the North of the Aegean. The sanctuary of Artemis is an important religious marker for understanding the urban expansion of the city, as well as the dynamics of local female worship. The data collection took place from the publication of the descriptive catalog of the black figures lekane of Thassos by A. Coulié in La céramique thasiennes à figures noires of 2002 in ÉtTh XIX, the analysis of a sample of material in loco and the data collection contexts from the Bulletin Correspondance Hellenique, in which we seek to delve deeper into the analysis of archaeological contexts. This study is part of the research in the doctoral thesis, in which we analyzed a sample of 54 vases in the Museum of Thasos, a total of 126 fragments of lekane found in the sanctuary of Artemis. In this article, we will present the analysis of 2 fragments of lekane from the cutting of decorative elements of animal figures typically from Eastern Greece in the archaic period and animals with a monstrous aspect, apparently common signs in the context in question. The theoretical-methodological contribution allowed us to observe important aspects of the particularities of the female cult in Thasos, from the re-insertion of the lekane in the contextual universe and the unveiling of aspects that characterize female and religious attendance from the sectored contexts of Artemísion.
Estradiol- and Progesterone-Associated Changes in microRNA-Induced Silencing and Reduced Antiseizure Efficacy of an Antagomir in Female Mice
Authors: Tiwari Durgesh , Rajathi Valerine , Rymer Jeffrey K. , Beasley Lindsay N. , McGann Amanda M. , Bunk Alexander T. , Parkins Emma V. , Rice McKenzie F. , Smith Katie E. , Ritter David M. , White Angela R. , Doerning Carolyn M. , Gross Christina 
Published: July 2023

AbstractAbout one-third of individuals living with epilepsy have treatment-resistant seizures. Alternative therapeutic strategies are thus urgently needed. One potential novel treatment target is miRNA-induced silencing, which is differentially regulated in epilepsy. Inhibitors (antagomirs) of specific microRNAs (miRNAs) have shown therapeutic promise in preclinical epilepsy studies; however, these studies were mainly conducted in male rodent models, and research into miRNA regulation in females and by female hormones in epilepsy is scarce. This is problematic because female sex and the menstrual cycle can affect the disease course of epilepsy and may, therefore, also alter the efficacy of potential miRNA-targeted treatments. Here, we used the proconvulsant miRNA miR-324-5p and its target, the potassium channel Kv4.2, as an example to test how miRNA-induced silencing and the efficacy of antagomirs in epilepsy are altered in female mice. We showed that Kv4.2 protein is reduced after seizures in female mice similar to male mice; however, in contrast to male mice, miRNA-induced silencing of Kv4.2 is unchanged, and miR-324-5p activity, as measured by the association with the RNA-induced silencing complex, is reduced in females after seizure. Moreover, an miR-324-5p antagomir does not consistently reduce seizure frequency or increase Kv4.2 in female mice. As a possible underlying mechanism, we found that miR-324-5p activity and the silencing of Kv4.2 in the brain were differentially correlated with plasma levels of 17β-estradiol and progesterone. Our results suggest that hormonal fluctuations in sexually mature female mice influence miRNA-induced silencing and could alter the efficacy of potential future miRNA-based treatments for epilepsy in females.
Bursting Dynamics Based on the Persistent Na+and Na+/K+Pump Currents: A Dynamic Clamp Approach
Authors: Erazo-Toscano Ricardo , Fomenko Mykhailo , Core Samuel , Calabrese Ronald L. , Cymbalyuk Gennady 
Published: July 2023

AbstractLife-supporting rhythmic motor functions like heart-beating in invertebrates and breathing in vertebrates require an indefatigable generation of a robust rhythm by specialized oscillatory circuits, central pattern generators (CPGs). These CPGs should be sufficiently flexible to adjust to environmental changes and behavioral goals. Continuous self-sustained operation of bursting neurons requires intracellular Na+concentration to remain in a functional range and to have checks and balances of the Na+fluxes met on a cycle-to-cycle basis during bursting. We hypothesize that at a high excitability state, the interaction of the Na+/K+pump current, Ipump, and persistent Na+current, INaP, produces a mechanism supporting functional bursting. INaPis a low voltage-activated inward current that initiates and supports the bursting phase. This current does not inactivate and is a significant source of Na+influx. Ipumpis an outward current activated by [Na+]iand is the major source of Na+efflux. Both currents are active and counteract each other between and during bursts. We apply a combination of electrophysiology, computational modeling, and dynamic clamp to investigate the role of Ipumpand INaPin the leech heartbeat CPG interneurons (HN neurons). Applying dynamic clamp to introduce additional Ipumpand INaPinto the dynamics of living synaptically isolated HN neurons in real time, we show that their joint increase produces transition into a new bursting regime characterized by higher spike frequency and larger amplitude of the membrane potential oscillations. Further increase of Ipumpspeeds up this rhythm by shortening burst duration (BD) and interburst interval (IBI).