bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monte Carlo simulation of 64Cu production
Authors: Wang Tianquan , Zhang Hu , Zhang Jiuhui , Wang Ruimin , Zhang Xiaofei , Yin Yongzhi , Fan Wei 
Published: September 2023

Abstract
Cooper-64 (64Cu) has good potential for use in the diagnosis and treatment of tumors. It can be produced by irradiating an enriched 64Ni target with a small proton cyclotron system. Based on the demand for 64Cu, a suitable production plan can be developed. Due to the high cost of 64Ni, it is important to simulate the production process in order to find a cost-effective method for producing 64Cu. In this work, Geant4 software was used in conjunction with the Evaluated Nuclear Data File (ENDF/B-VII.1) and the TALYS-based Evaluated Nuclear Data Library (TENDL-2019) to calculate the 64Ni(p,n)64Cu reaction cross section. The TRIM code was then used to calculate the proton projection range in the 64Ni target. Finally, the saturation yield of 64Cu was obtained for proton energies between 2 MeV and 20 MeV and target thicknesses ranging from 0.1 mm to 1 mm.
Functional hydrogel dressings for wound management: a comprehensive review
Authors: Fu Xinming , Zheng Long , Wen Xianjie , Yin Xianze 
Published: September 2023

Abstract
Hydrogels have gained significant attention as wound dressings due to their potential for rapid healing. Researchers have actively explored a range of techniques for antimicrobial applications, including incorporating drug payloads, utilizing inorganic nanometals, and harnessing the properties of natural cationic polymers. In terms of hemostasis and coagulation promotion, techniques such as drug delivery, adhesive physical hemostasis, and adhesive functional groups have been studied. To control inflammation, researchers have investigated the application of natural antioxidants and antioxidant functional groups, which have demonstrated anti-inflammatory effects. Furthermore, the smart responsiveness of hydrogel wound dressings to pH, temperature, and light has been explored. This review presents a summary of the research progress and application prospects in these areas and offers an outlook on the future development direction of hydrogel wound dressings.
The damage mechanism of tension-tension fatigue interaction with creep damage of the compacted graphite cast iron alloy at high temperatures
Authors: Yue Wu , Zehui Pei , Zhijun Ma , Zhong Yang , Yongchun Guo , Minxian Liang , Jianping Li , Hua Chen 
Published: September 2023

Abstract
The tension-tension fatigue test of the compacted graphite cast iron (CGI) alloy was carried out by RDL100 universal testing at 500 °C and 550 °C, respectively. A tension-tension trapezoidal load is applied to the CGI specimen. Because of the time-dependent deformation at elevated temperatures, the stress–strain curve presents hysteresis loops, and the area of the hysteresis loop increases gradually with continuous cyclic loading and sustained loading times. Intergranular and transgranular cracks in the microstructure accelerate the CGI alloy fracture failure. The fatigue life is sensitive to the short loading time and decreases with the sustained loading time exponentially under the tension-tension fatigue condition. The short holding time has a great influence on the fatigue life of CGI. The fatigue behavior of CGI alloys and the influence of holding time on the fatigue life can be characterized by y = aexp(bx) (a and b are constants, can be fitted through the test data). In addition, the fatigue life of CGI alloy can be predicted by the ductility depletion method. But the equivalent stress amplitude needs to be modified to eliminate the effects of oxidation damage.
Investigating the material removal mechanism and cutting performance in ultrasonic vibration-assisted milling of carbon fibre reinforced thermoplastic
Authors: Liu Sinan , Sun Yu , Du Yu , Zhang Zhijun , Wu Xiaojie 
Published: September 2023

Abstract
Carbon fibre reinforced thermoplastic (CFRTP) has emerged as a sustainable alternative to carbon fibre reinforced plastic (CFRP) due to its improved reparability and recyclability. CFRTP, particularly carbon fibre reinforced polyetheretherketone (CF/PEEK), is a high-performance material known for its excellent mechanical, thermal, and corrosion resistance properties, making it well-suited for extreme environments in civil aviation equipment. However, machining processes such as milling often result in defects due to the material’s high toughness and anisotropic nature. This study aims to investigate the material removal mechanism in ultrasonic-assisted milling (UAM) of CF/PEEK and compare the effects of fibre cutting angle (θ) and milling processes on milling performance. To simulate the fibre fracture mechanisms under different θ, finite element analysis (FEA) is employed. The results reveal different fracture modes, including bending, bending-shear, compression, and compression-shear, at various θ. Additionally, UAM demonstrates lower cutting forces and temperatures compared to conventional milling (CM). Notably, UAM greatly improves surface quality by reducing burr height and facilitating chip evacuation, while also enhancing surface integrity by minimizing cavity defects and fibre pull-out phenomena. These findings contribute to the development of low-damage machining methods that aim to achieve higher accuracy in CFRTP.
Multi-organ segmentation of CT via convolutional neural network: impact of training setting and scanner manufacturer
Authors: Weisman Amy J , Huff Daniel T , Govindan Rajkumar Munian , Chen Song , Perk Timothy G 
Published: September 2023

Abstract

Objective. Automated organ segmentation on CT images can enable the clinical use of advanced quantitative software devices, but model performance sensitivities must be understood before widespread adoption can occur. The goal of this study was to investigate performance differences between Convolutional Neural Networks (CNNs) trained to segment one (single-class) versus multiple (multi-class) organs, and between CNNs trained on scans from a single manufacturer versus multiple manufacturers. Methods. The multi-class CNN was trained on CT images obtained from 455 whole-body PET/CT scans (413 for training, 42 for testing) taken with Siemens, GE, and Phillips PET/CT scanners where 16 organs were segmented. The multi-class CNN was compared to 16 smaller single-class CNNs trained using the same data, but with segmentations of only one organ per model. In addition, CNNs trained on Siemens-only (N = 186) and GE-only (N = 219) scans (manufacturer-specific) were compared with CNNs trained on data from both Siemens and GE scanners (manufacturer-mixed). Segmentation performance was quantified using five performance metrics, including the Dice Similarity Coefficient (DSC). Results. The multi-class CNN performed well compared to previous studies, even in organs usually considered difficult auto-segmentation targets (e.g., pancreas, bowel). Segmentations from the multi-class CNN were significantly superior to those from smaller single-class CNNs in most organs, and the 16 single-class models took, on average, six times longer to segment all 16 organs compared to the single multi-class model. The manufacturer-mixed approach achieved minimally higher performance over the manufacturer-specific approach. Significance. A CNN trained on contours of multiple organs and CT data from multiple manufacturers yielded high-quality segmentations. Such a model is an essential enabler of image processing in a software device that quantifies and analyzes such data to determine a patient’s treatment response. To date, this activity of whole organ segmentation has not been adopted due to the intense manual workload and time required.
Partially insoluble regenerated silk fibroin film induced by UV irradiation for electronic skins
Authors: Song Fangmiao , Zhou Mengyuan , Sun Wei , Qiao Yan , Lu Zhisong 
Published: September 2023

Abstract
The regenerated silk fibroin (RSF) film has been regarded as an ideal substrate for biocompatible, flexible, and biodegradable electronic skin (e-skin) devices. However, it is still a great challenge to balance the flexibility and solubility of the RSF film by adjusting its secondary structure. Herein, a film prepared with the hydrolyzed RSF was exposed to the 254 nm ultraviolet (UV) light to prepare a crosslinked and partially water-insoluble substrate for a strain-sensing e-skin. The hydrolyzed low-molecular-weight RSF was produced by heating the LiBr-silk fibroin solution at 85 °C for a certain duration. The film cast with the hydrolyzed RSF solution could be thoroughly dissolved in water rapidly. The UV irradiation could induce the crosslinking of the low-molecular-weight RSF to form insoluble substances, thus producing a partially insoluble RSF film. After silver nanowires painting, an e-skin strain sensor was successfully constructed based on the UV-irradiated film. The sensor shows a fast response time (2.01 s), high sensitivity (GF = 1.03 within 0%–40% strain range), and good stability. The device could be tightly attached to human skin with a drop of water. The finger, wrist, elbow, and knee bending could be sensitively detected in real-time. The head nodding and mouth opening could also be sensed by sticking the e-skin at the neck and cheek, respectively. This work may provide a facile way to prepare a stretchable and stickable RSF film, which could serve as an ideal substrate of low-cost, biodegradable, direct-to-skin sensors for wearable applications.
Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)
Authors: Umino Mitsuki , Okuda Mayumi , Ohkubo Takeshi , Fujii Tsutomu , Matsubara Kiminori 
Published: September 2023

ABSTRACT
We evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.
Normal values for native T1 at 1.5 T in the pericardial fluid of healthy volunteers
Authors: Thalén Simon , Ramos Joao G , Engblom Henrik , Sigfridsson Andreas , Sörensson Peder , Ugander Martin 
Published: September 2023

Abstract

Aims
T1 mapping cardiovascular magnetic resonance (CMR) imaging has been used to characterize pericardial effusions. The aim of this study was to measure pericardial fluid native T1 values in healthy volunteers to establish normal values.

Methods and results
Prospectively recruited volunteers (n = 30) underwent CMR at 1.5 T, and native T1 maps were acquired using a modified look-locker inversion recovery 5s(3s)3s acquisition scheme. A volume of pericardial fluid was imaged in a short-axis slice and in a slice perpendicular to the short-axis orientation. A reliable measurement had a region of interest (ROI) size &gt; 10 mm2, coefficient of variation &lt; 10%, and a relative difference &lt; 5% between the two slice orientations. In 26/30 (87%) of volunteers, there was a sufficient amount of pericardial fluid to enable reliable measurement. Native T1 of pericardial fluid was 3262 ± 163 (95% normal limits 2943–3581 ms) and did not differ in the perpendicular slice orientation (3267 ± 173 ms, P = 0.75), due to sex (female 3311 ± 177 vs. male 3220 ± 142 ms, P = 0.17), age (R2 = 0.03, P = 0.44), heart rate (R2 = 0.005, P = 0.7), or size of the ROI (0.06, P = 0.23).

Conclusion
This study shows that T1 values can be reliably measured in the pericardial fluid of healthy volunteers. It is the first to report normal reference ranges for T1 values at 1.5 T in the pericardial fluid of healthy volunteers.
Paediatric quality of life in toddlers and children who underwent arterial switch operation beyond early neonatal period
Authors: Ramanan Sowmya , Gopalakrishnan Arun , Sundaram Soumya , Varma Ravi Prasad , Gopakumar Deepak , Viswam Vinitha K , Satheesan Rahul , Baruah Sudip Dutta , Menon Sabarinath , Dharan Baiju S 
Published: September 2023

Abstract

OBJECTIVES
The aim of this study was to evaluate the quality of life (QOL) of children who underwent the arterial switch operation (ASO) for Transposition of Great Arteries in our population and, specifically, to explore early modifiable factors and the influence of parental and socioeconomic factors on the QOL of these children.

METHODS
Cross-sectional study using Paediatric Quality of Life Inventory™ 3.0 Cardiac Module was carried out on 3- to 12-year-old children who had undergone ASO between the years 2012–2018. Socioeconomic status was calculated using the modified Kuppuswamy scale (2019). Other clinical factors with possible bearing on the outcome were also analysed.

RESULTS
Immediate survival after surgery was 196 out of 208 (94.2%) with an attrition of 19 patients (9.6%) over the follow-up period. Most surviving children (98.9%) had started formal schooling in age-appropriate classes. Two children had severe neuromotor impairment. The median cumulative health-related QOL score of the children was 97.9 (interquartile range 4.2) at 5.6 ± 1.27 years of life. The median scores each of the health-related QOL parameters, viz, heart problem symptoms, treatment compliance, perceived physical appearance, treatment-related anxiety, cognitive problems, and communication was 100 with negative skewing.

CONCLUSIONS
Excellent QOL was observed in most children after ASO with the median total paediatric QOL scores in all domains of 97.9. Social factors did not show a statistically significant influence on the QOL parameters in the current cohort. The gradually declining trend across the age groups emphasizes the need for continued follow-up for early identification of possible correctable factors and initiating intervention to ensure good QOL into teenage and adulthood.
Comparison of decision tree and naïve Bayes algorithms in detecting trace residue of gasoline based on gas chromatography–mass spectrometry data
Authors: Md Ghazi Md Gezani Bin , Chuen Lee Loong , Samsudin Aznor S , Sino Hukil 
Published: September 2023

Abstract
Fire debris analysis aims to detect and identify any ignitable liquid residues in burnt residues collected at a fire scene. Typically, the burnt residues are analysed using gas chromatography–mass spectrometry (GC–MS) and are manually interpreted. The interpretation process can be laborious due to the complexity and high dimensionality of the GC–MS data. Therefore, this study aims to compare the potential of classification and regression tree (CART) and naïve Bayes (NB) algorithms in analysing the pixel-level GC–MS data of fire debris. The data comprise 14 positive (i.e. fire debris with traces of gasoline) and 24 negative (i.e. fire debris without traces of gasoline) samples. The differences between the positive and negative samples were first inspected based on the mean chromatograms and scores plots of the principal component analysis technique. Then, CART and NB algorithms were independently applied to the GC–MS data. Stratified random resampling was applied to prepare three sets of 200 pairs of training and testing samples (i.e. split ratio of 7:3, 8:2, and 9:1) for estimating the prediction accuracies. Although both the positive and negative samples were hardly differentiated based on the mean chromatograms and scores plots of principal component analysis, the respective NB and CART predictive models produced satisfactory performances with the normalized GC–MS data, i.e. majority achieved prediction accuracy &gt;70%. NB consistently outperformed CART based on the prediction accuracies of testing samples and the corresponding risk of overfitting except when evaluated using only 10% of samples. The accuracy of CART was found to be inversely proportional to the number of testing samples; meanwhile, NB demonstrated rather consistent performances across the three split ratios. In conclusion, NB seems to be much better than CART based on the robustness against the number of testing samples and the consistent lower risk of overfitting.
Male-derived transcripts isolated from the mated female reproductive tract in Drosophila melanogaster
Authors: Cridland Julie M , Begun David J 
Published: September 2023

Abstract
In species with internal fertilization, sperm, and seminal fluid are transferred from male to female during mating. While both sperm and seminal fluid contain various types of molecules, including RNA, the role of most of these molecules in the coordination of fertilization or in other possible functions is poorly understood. In Drosophila, exosomes from the accessory gland, which produces seminal fluid, are transferred to females, but their potential cargoes have not been described. Moreover, while the RNA composition of sperm has been described in several mammalian species, little work on this problem has occurred in Drosophila. Here we use single nucleotide polymorphism differences between males and females from a set of highly inbred lines of D. melanogaster, and transcriptome data from the female reproductive tract, sperm, testis, and accessory gland, to investigate the potential origin, male vs female, RNA molecules isolated from 3 female reproductive tract organs, the seminal receptacle and spermatheca, which store sperm, and the parovaria, which does not. We find that mated females carry male-derived transcripts from many genes, including those that are markers of the accessory gland and known seminal fluid proteins. Our observations also support the idea that intact sperm transcripts can be isolated from the female sperm storage organs.
Scaling the discrete-time Wright–Fisher model to biobank-scale datasets
Authors: Spence Jeffrey P , Zeng Tony , Mostafavi Hakhamanesh , Pritchard Jonathan K 
Published: September 2023

Abstract
The discrete-time Wright–Fisher (DTWF) model and its diffusion limit are central to population genetics. These models can describe the forward-in-time evolution of allele frequencies in a population resulting from genetic drift, mutation, and selection. Computing likelihoods under the diffusion process is feasible, but the diffusion approximation breaks down for large samples or in the presence of strong selection. Existing methods for computing likelihoods under the DTWF model do not scale to current exome sequencing sample sizes in the hundreds of thousands. Here, we present a scalable algorithm that approximates the DTWF model with provably bounded error. Our approach relies on two key observations about the DTWF model. The first is that transition probabilities under the model are approximately sparse. The second is that transition distributions for similar starting allele frequencies are extremely close as distributions. Together, these observations enable approximate matrix–vector multiplication in linear (as opposed to the usual quadratic) time. We prove similar properties for Hypergeometric distributions, enabling fast computation of likelihoods for subsamples of the population. We show theoretically and in practice that this approximation is highly accurate and can scale to population sizes in the tens of millions, paving the way for rigorous biobank-scale inference. Finally, we use our results to estimate the impact of larger samples on estimating selection coefficients for loss-of-function variants. We find that increasing sample sizes beyond existing large exome sequencing cohorts will provide essentially no additional information except for genes with the most extreme fitness effects.
Noninvasive 3D-CT simulation versus glue injection to localize small pulmonary nodules prior to anatomical segmentectomy: a randomized controlled trial
Authors: Fu Linhai , Wu Wenbin , Oblokulov Alisherjon , Zhu Ting , Ma Zhifeng , Wang Haiyong , Wu Yuanlin , Li Zhupeng , Yu Guangmao , Zhang Chu , Zhang Miao 
Published: September 2023

Abstract

OBJECTIVES
This study aimed to investigate whether adding glue injection to three-dimensional computed tomography bronchography and angiography (3D-CTBA) has extra benefits to facilitate anatomical segmentectomy for pulmonary nodules.

METHODS
We conducted a randomized controlled trial. The patients undergoing thoracoscopic segmentectomy assisted with 3D-CTBA simulation were enrolled. Then, they were divided into the 3D-CTBA group and the glue-labelling group who received additional computed tomography-guided percutaneous glue (2-octyl cyanoacrylate) injection to label the nodules. The primary outcome was the resection rate of the nodules, and the secondary measures included the operation time, complications and thorax drainage.

RESULTS
A total of 173 patients were randomized into the 3D-CTBA group (89 patients) and glue-labelling group (84 patients) between January 2018 and March 2019. Before the segmentectomy, the patients using glue labelling recorded 5 (6.0%) cases of pneumothorax, 2 (2.4%) cases of haemothorax and 1 (1.2%) case of severe chest pain. All the surgical procedure was performed fluently and safely. The resection rate of the nodules was 100% in both groups. Furthermore, these patients demonstrated similar operation time [(141.5 ± 41.9) vs (142.1 ± 38.9) min], estimated blood loss [(111.3 ± 74.0) vs (106.0 ± 63.8) ml], duration of chest tube duration [(5.1 ± 3.0) vs (5.0 ± 3.5) days] and total drainage volume [(872.3 ± 643.1) vs (826.7 ± 806.0) ml], with a P-value of &gt;0.05 respectively. In addition, 6 (7.1%) patients in the glue-labelling group and 6 (6.7%) patients in the 3D-CTBA group reported air leakage (&gt;5 days) and chylothorax.

CONCLUSIONS
Noninvasive 3D-CTBA alone is probably sufficient to facilitate anatomical segmentectomy. The additional invasive glue labelling could be avoided in selected patients who undergo intentional segmentectomy.

Clinical trial registration
The trial was registered under the Chinese Clinical Trial Registry (ChiCTR). Identifier: ChiCTR1800018293, https://www.chictr.org.cn/showproj.html?proj=29345.
Safety and efficacy of tislelizumab plus chemotherapy as preoperative treatment in potentially resectable locally advanced non-small-cell lung cancer patients
Authors: Huang Xuhua , Zhu Linhai , Liu Jiacong , Wang Yanye , Yu Li , Wu Simeng , Lv Wang , Hu Jian 
Published: September 2023

Abstract

OBJECTIVES
Locally advanced non-small-cell lung cancer (LA-NSCLC) requires more preoperative regiments in the era of immunotherapy. Tislelizumab was approved for first-line treatment for advanced lung cancer, bringing hope for preoperative therapy in LA-NSCLC. The aim of this study was to investigate the safety and efficacy of preoperative tislelizumab plus chemotherapy in LA-NSCLC.

METHODS
The medical records at the First Affiliated Hospital of Zhejiang University were examined retrospectively from September 2019 to June 2022 for this descriptive single-arm cohort study. Patients with LA-NSCLC were treated with tislelizumab plus platinum-based dual-drug regimens for 2–6 cycles and regular imaging assessments were performed every 1–2 cycles. Data including demographic characteristics, clinicopathological staging, adverse events and surgery-related details were recorded in specifically designed forms.

RESULTS
Forty patients met the inclusion criteria of the study and 23 patients underwent curative intent surgeries. Significantly clinical and pathological downstaging was observed, with the objective response rate being 65.00%, leading to a major pathological remission (MPR) rate of 56.52% and a pathological complete remission (pCR) rate of 34.78%. Grade 3–4 treatment-related adverse events occurred in 4 patients and no perioperative death occurred. The 1-year progress-free survival rate and the 1-year overall survival rate were 85.0% and 90.0%, respectively.

CONCLUSIONS
Tislelizumab plus chemotherapy as preoperative therapy demonstrates promising antitumour activity for potentially resectable LA-NSCLC with high MPR, pCR and acceptable toxicity and survival.