bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary investigation on biological possessions of Saquinavir‐modified quinoline‐derived azadipeptidomimetics
Authors: Perumal Gopi , Govindan Karthick , Jayaram Alageswaran , Sundaramoorthi Sarvesweri , Lin Wei‐Yu 
Published: January 2023

AbstractHerein, azadipeptidomimetic molecules were designed and synthesized using a quinoline‐histidine‐amino acid sequence with terminal amino acid modification. In‐silico studies were carried out to evaluate the compound's HIV protease‐1 inhibition temperament. In‐vitro anti‐proliferative possessions of the test compounds were studied by executing a series of experiments, namely DNA binding, bovine serum albumin (BSA) binding capability, and cytotoxicity assay on MCF‐7 cells. The molecule 5j exhibited remarkable results in all experiments; it has an excellent DNA binding constant (3.76 × 105), higher serum albumin unbound concentration of 5.96%, and a significant antiproliferative effect on MCF‐7 cells with IC50 value 0.31 nM.
The role of contrast‐enhanced ultrasound in the diagnosis and guiding therapy of early cervical ectopic pregnancy
Authors: Li Hui , Chen Lixia 
Published: January 2023

AbstractWe described the ultrasonic imaging characteristics of four patients with cervical ectopic pregnancy (CEP) and inevitable miscarriage (IM) with the gestational sac (GS) located at the level of the cervical canal discussed and analyzed them in combination with relevant data, such as surgery and outcomes. It was found that contrast‐enhanced ultrasound (CEUS) could provide a more accurate differential diagnosis of early CEP and IM than conventional ultrasound (US), thus providing more effective guidance for clinical therapy. In CEP, CEUS shows sustained annular hyperenhancement of the GS wall. However, CEUS shows nonenhancement or pedicle‐like enhancement in IM with the GS located at the level of the cervical canal.
In‐hospital deprescribing in the real world – a clinician‐led approach to hyperpolypharmacy
Authors: Muhandiramge Jaidyn , Dev Tara , Kong Jason , Hall Kylie , Wadhwa Vikas 
Published: January 2023

AbstractBackgroundA lack of clear guidelines for medication cessation has contributed to the proliferation of polypharmacy. Hospitalisation provides a unique opportunity for initiating deprescribing. Deprescribing interventions are usually pharmacist‐ or multidisciplinary team‐led and are typically safe and beneficial for patients. However, few studies have explored interventions that are implementable by clinicians at the bedside.AimTo explore the efficacy and feasibility of a clinician‐led deprescribing intervention on an acute general medicine ward.MethodA multifaceted intervention was implemented comprising (a) education sessions on deprescribing and (b) a deprescribing alert in the bedside folders of patients with hyperpolypharmacy (>10 medications). Using a historical cohort study design, data from the intervention cohort were compared to a historical control group. A subset of the intervention cohort was surveyed after discharge regarding attitudes toward deprescribing.ResultsWe recruited 1333 patients and had complete data for 1169 (nintervention = 888, ncontrol = 281). The prevalence of hyperpolypharmacy decreased from 28% to 26% in the intervention cohort, but this reduction was not statistically significant (net change = −1, interquartile range [IQR] = −2–0; p = 0.26). There was similarly no statistically significant change in medication numbers due to the intervention across other subgroups. Most patients agreed they were taking too many medications and supported deprescribing.ConclusionsDespite observing no statistically significant effect of the intervention, we demonstrated the feasibility of introducing clinician‐led deprescribing interventions in resource‐poor, busy inpatient units. Simple, innovative deprescribing interventions in hospital settings, along with the measurement of long‐term patient outcomes and medication adverse effects, should be investigated further in large inpatient cohorts.
Ultrasound shear wave elastography for patients with sialolithiasis undergoing interventional sialendoscopy
Authors: Chang Chia‐Fan , Wang Hsin‐Kai 
Published: January 2023

AbstractObjectiveUltrasound shear wave elastography is an objective tool to evaluate the stiffness of human tissues. Patients with sialolithiasis could be treated by interventional sialendoscopy with a high success rate. Sialolithiasis could be extracted, and the diseased gland could be preserved and evaluated after treatment. Whether ultrasound shear wave elastography could be used for objective outcome measurement and short‐term follow‐up of the parenchyma of gland in patients with sialolithiasis remains unclear.MethodsThis retrospective self‐controlled study was conducted. Patients with sialolithiasis treated by interventional sialendoscopy and followed by high‐resolution ultrasound shear wave elastography were selected between January and September 2017.ResultsSeventeen patients with sialolithiasis (mean age: 39.63 ± 12.49 years), including 10 women and 7 men, were enrolled. Fifteen patients had sialolithiasis in the submandibular gland and two in the parotid gland. The preoperative value of shear wave velocity was significantly higher in the diseased gland than in the contralateral normal gland (p < .001; 95% confidence interval [CI], 0.3915–0.6046). After successful treatment by interventional sialendoscopy surgery, the shear wave velocity of the diseased gland decreased significantly (p = 0.001; 95% CI, −0.38792 to −0.20474). However, there was a significant difference between the diseased and contralateral normal glands (p = 0.001; 95% CI, 0.0423–0.2895) after 1.55 months of surgery.ConclusionUltrasound shear wave elastography could be an adjuvant tool to distinguish sialolithiasis‐affected diseased glands from contralateral normal glands and assess the short‐term treatment outcome objectively. The changing trend of shear wave velocity could help monitor the healing process of the parenchyma in the diseased gland after treatment.Level of Evidence4
ENG‐TL inspired dual‐polarized antenna using curved meander, two‐arm Archimedean spirals and CSRR mushroom
Authors: Ameen Mohammad , Chaudhary Raghvendra Kumar 
Published: January 2023

AbstractThis work describes the design and development of a dual‐band and dual‐polarized epsilon‐negative transmission line‐inspired antenna for wireless applications. In the proposed antenna, the implementation of curved meander lines results in antenna miniaturization; bandwidth enhancement is mainly due to the additional loading of complementary split‐ring resonator‐based mushroom resonator. Further, circular polarization radiation is obtained due to the additional loading of two‐arm Archimedean spiral resonators in the backside of the antenna forming a hybrid metamaterial structure. The proposed dual‐polarized antenna provides an overall electrical dimension of 0.17λ0 × 0.25λ0 × 0.026λ0 at the first resonating frequency of 2.49 GHz. The proposed antenna provides a fractional bandwidth of 7.22% (2.40–2.58 GHz) and 1.13% (2.62–2.65 GHz) for the first and second bands, respectively. Furthermore, the intended antenna provides maximum gain values of 1.28 dBi at 2.41 GHz and 1.94 dBi at 2.64 GHz for the first and second bands, respectively. As a result, the proposed antenna is well suited for ISM 2.4 GHz (2.4–2.484 GHz), WLAN/WiFi IEEE 802.11 b/g/n (2.4–2.48 GHz) and LTE 2500 (2.5–2.69 GHz) applications.
Analysis of network function sharing in Content Delivery Network‐as‐a‐service slicing scenarios
Authors: Contreras Luis M. , Solano Alberto , Cano Francisco , Folgueira Jesus 
Published: January 2023

AbstractVideo content consumption is currently dominating the mix of traffic observed in Internet service provider (ISP) networks. The distribution of that content is usually performed by means of content delivery network (CDN) caches storing and delivering multimedia. The advent of virtualization is calling attention to the CDN providers as a use case for virtualizing the cache function. In parallel, there is a trend for sharing network infrastructures as a way of reducing deployment costs by ISPs. Then, an interesting scenario emerges when considering the possibility of sharing virtualized cache functions among ISPs which are sharing a common physical infrastructure, mostly considering that those ISPs offer similar video content catalogs to end users. Furthermore, when deciding to share the caches among ISPs, it is interesting to understand the impacts due to limiting the storage capacity at the edge sites. This paper investigates through simulations the potential efficiencies that can be achieved when sharing a virtual cache function if compared with the classical approach of independent virtual caches operated per ISP, as well as the implications of limiting the storage capacity of the caches at the edge.
A case of schizophrenia with relapsed catatonia successfully treated with blonanserin transdermal patch
Authors: Hagikura Minako , Inada Toshiya 
Published: January 2023

AbstractBackgroundCatatonia is a syndrome that may present with stupor, immobility, and postural retention, and appears in various primary disorders including schizophrenia, depressive disorders, and neurodevelopmental disorders.Case presentationIn this report, we describe a 34‐year‐old female patient with schizophrenia, who had previously been treated with antipsychotic agents to improve psychotic symptoms with delusional symptoms and catatonia. However, she relapsed with catatonic symptoms around 1 year after she voluntarily discontinued the prescribed antipsychotic medications by herself. Her catatonia was successfully improved using the transdermal blonanserin patch, a drug formulation globally first approved in Japan in 2019.DiscussionAlthough benzodiazepines or electroconvulsive therapy have been recommended as the first‐line treatment of catatonic manifestation observed in psychiatric patients, this patient responded well to antipsychotic blonanserin. From the differential drug responses, catatonia may be the complex of heterogeneous conditions with different pathophysiologies.
Tensile behavior analysis of CFRP (carbon‐fiber‐reinforced‐polymer)–titanium joint under preload
Authors: Li Haiyin , Shi Jianwei , Zhao Jiangming , Zheng Yanping , Duan Yuechen , Li Chen 
Published: January 2023

AbstractCompared with the traditional connection (bonding and bolting), the hybrid connection has attracted increasing attention in various fields for its better mechanical properties. Some research demonstrates that providing preload, a necessary condition for bolted connection increases the strength of the conventional bolted joint. However, those research depends on the test procedure, and there are few studies on the mixed joint. In this paper, we studied the tensile behavior of CFRP（carbon‐fiber‐reinforced‐polymer)/titanium alloy multi‐bolt hybrid bonded/bolted (HBB) joints under preload with multiple parameters, such as the size of preload, the number of bolts, and the way of connection. A finite element model of joint strength prediction under preload based on the 3D Hashin failure criterion was established and combined with experimental verification. This work reveals that: The preload can effectively reduce the stress concentration around the bolt hole of CFRP laminate and enhance the strength of the mechanically fastened joints. As for the HBB joint, the simulation results of the scalar stiffness degradation (SDEG) of the adhesive layer indicate that the application of preload can also effectively slow down the failure process of the joint and has a significant impact on the strength of the joint. However, for the single‐bearing full‐thread bolted joint, the sizeable preloading force will lead to the extrusion deformation of the bolt thread and screw, and excessive preloading may even lead to the shear failure of the bolt.
MSC‐EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF‐1α
Authors: Wang Juanmei , Zhang Aimin , Huang Furong , Xu Jun , Zhao Menghua 
Published: January 2023

AbstractBackgroundBronchopulmonary dysplasia (BPD) is a major complication of premature infants and an important cause of morbidity and mortality. This study investigates the effect of the combination of mesenchymal stem cells‐derived exosomes (MSC‐EXO) and tempol on BPD and analyzes its mechanism.MethodsMSC‐EXO was extracted by centrifugation and identified by transmission electron microscopy (TEM), nanoparticle tracking analysis, and western blot analysis (WB). Tidal volume (TV), minute ventilation (MV), peak inspiratory flow (PIF), and dynamic pulmonary compliance (Cdyn) of rats were measured by BuxCo pulmonary function experimental platform. Hematoxylin‐eosin staining was performed to observe the lung morphology and radical alveolar count (RAC) and mean linear intercept (MLI) were assessed. Immunofluorescence (IF) was conducted to detect the expression of CD31 and α‐SMA in pulmonary blood vessels. The kits were used to calculate malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant capacity (TAOC) concentration in lung tissue. Enzyme linked immunosorbent assay was applied to detect the levels of IL‐1β, IL‐17, IL‐6, and IFN‐γ in bronchoalveolar lavage fluid. In addition, the expressions of HIF‐1α, vascular endothelial growth factor (VEGF), p‐PI3K, and p‐AKT were analyzed by WB and IF.ResultsWe successfully extracted and identified MSC‐EXO. In BPD rats, TV, MV, PIF, and Cdyn decreased, alveoli were simplified, and the number of interalveoli small vessels, blood vessel density decreased. Moreover, RAC, CD31, TAOC, and SOD decreased, and MLI, α‐SMA, MDA, IL‐1β, IL‐17, IL‐6, and IFN‐γ increased, which was reversed by the combination of MSC‐EXO and tempol treatment after combined treatment. In addition, the expression levels of HIF‐1α, VEGF, p‐PI3K, and p‐AKT were increased after combined treatment.ConclusionsCombined treatment could improve lung tissue injury, promote pulmonary vascular remodeling, restore lung function, and inhibit oxidative stress in BPD rats. These effects were achieved through activation of HIF‐1α.
Comprehensive lipidome of human plasma using minimal sample manipulation by liquid chromatography coupled with mass spectrometry
Authors: Sousa Bebiana C. , Klein Zulema Gonzalez , Taylor Diane , West Greg , Huipeng Aveline Neo , Wakelam Michael J. O. , Lopez‐Clavijo Andrea F. 
Published: January 2023

RationaleThe present work shows comprehensive chromatographic methods and MS conditions that have been developed based on the chemical properties of each lipid subclass to detect low‐abundance molecular species. This study shows that the developed methods can detect low‐ and/or very‐low‐abundant lipids like phosphatidic acid (PA) in the glycerophospholipid (GP) method; dihydroceramide (dhCer) and dihydrosphingosine/sphinganine (dhSPB) in the sphingolipid (SP) method; and lysophosphatidic acid (LPA), LPI, LPG and sphingosine‐1‐phosphate (SPBP) in the lysolipid method.MethodsAn optimised method for the extraction of lysolipids in plasma is used in addition to Folch extraction. Then, four chromatographic methods coupled with mass spectrometry using targeted and untargeted approaches are described here. Three of the methods use a tertiary pumping system to enable the inclusion of a gradient for analyte separation (pumps A and B) and an isocratic wash (pump C). This wash solution elutes interfering compounds that could cause background signal in the subsequent injections, reducing column lifetime.ResultsSemi‐quantitative values for 37 lipid subclasses are reported for a plasma sample (NIST SRM 1950). Furthermore, the methods presented here enabled the identification of 338 different lipid molecular species for GPs (mono‐ and diacyl‐phospholipds), SPs, sterols and glycerolipids. The methods have been validated, and the reproducibility is presented here.ConclusionsThe comprehensive analysis of the lipidome addressed here of glycerolipids, GPs, sterols and SPs is in good agreement with previously reported results, in the NIST SRM 1950 sample, by other laboratories. Ten lipid subclasses LPS, LPI, alkyl‐lysophosphatidic acid/alkenyl‐lysophosphatidic acid, alkyl‐lysophosphatidylethanolamine/alkenyl‐lysophosphatidylethanolamine, dhCer (d18:0), SPB (d18:1), dhSPB (d18:0) and SPBP (d18:2) have been detected using this comprehensive method and are uniquely reported here.
Beyond presence mapping: predicting fractional cover of non‐native vegetation in Sentinel‐2 imagery using an ensemble of MaxEnt models
Authors: Preston Todd M. , Johnston Aaron N. , Ebenhoch Kyle G. , Diehl Robert H. 
Published: January 2023

AbstractNon‐native species maps are important tools for understanding and managing biological invasions. We demonstrate a novel approach to extend presence modeling to map fractional cover (FC) of non‐native yellow sweet clover Melilotus officinalis in the Northern Great Plains, USA. We used ensembles of MaxEnt models to map FC across landscapes from satellite imagery trained from regional aerial imagery that was trained by local unmanned aerial vehicle (UAV) imagery. Clover cover from field surveys and classified UAV imagery were nearly identical (n = 22, R2 = 0.99). Two classified UAV images provided training data to map clover presence with MaxEnt and National Agricultural Imagery Program (NAIP) aerial imagery. We binned cover predictions from NAIP imagery within each Sentinel‐2 pixel into eight cover classes to create pure (100%) and FC (20%–95%) training data and modeled each class separately using MaxEnt and Sentinel‐2 imagery. We mapped pure clover with one classification threshold and compared its performance to 15 candidate maps that included FC predictions outside pure predictions. Each FC map represented alternative combinations of five MaxEnt thresholds and three approaches to assign cover to pixels with multiple predictions from the FC ensemble. Evaluations of performance with independent datasets revealed maps including FC corresponded to field (n = 32, R2 range: 0.39–0.68) and UAV (n = 20, R2 range: 0.61–0.84) data better than pure clover maps (R2 = 0.15 and 0.31, respectively). Overall, the pure clover map predicted 3.2% cover, whereas the three best performing FC maps predicted 6.6%–8.0% cover. Including FC predictions increased accuracy and cover predictions which can improve ecological understanding of invasions. Our method allows efficient FC mapping for vegetative species discernible in UAV imagery and may be especially useful for mapping rare, irruptive or patchily distributed species with poor representation in field data, which challenges landscape‐level mapping.
A Transient Pseudo‐Capacitor Using a Bioderived Ionic Liquid with Na Ions
Authors: Yamada Shunsuke 
Published: January 2023

AbstractA pseudo‐capacitor with transient behavior is applied in implantable, disposable, and bioresorbable devices, incorporating an Na ion‐doped bioderived ionic liquid, molybdenum trioxide (MoO3)‐covered molybdenum foil, and silk sheet as the electrolyte, electrode, and separator, respectively. Sodium lactate is dissolved in choline lactate as a source of Na ions. The Experimental results reveal that the Na ions are intercalated into the van der Waals gaps in MoO3, and the pseudo‐capacitor shows an areal capacitance (1.5 mF cm−2) that is three times larger than that without the Na ion. The fast ion diffusion of the electrolyte and the low resistance of the MoO3 and Mo interface result in an equivalent series resistance of 96 Ω. A cycle test indicates that the pseudo‐capacitor exhibited a high capacitance retention of 82.8% after 10 000 cycles. The transient behavior is confirmed by the dissolution of the pseudo‐capacitor into phosphate‐buffered saline solution after 101 days. Potential applications of transient pseudo‐capacitors include electronics without the need for device retrieval after use, including smart agriculture, implantable, and wearable devices.
Back to the origin: A spick‐and‐span sustainable approach for the devulcanization of ground tire rubber
Authors: Mondal Dipankar , Hait Sakrit , Ghorai Soumyajit , Wießner Sven , Das Amit , De Debapriya , Chattopadhyay Dipankar 
Published: January 2023

AbstractA new sustainable approach for the development of value added devulcanized rubber will augment its application in tire industry and play a significant role toward the product quality, production economy and market completion. The right choice of devulcanizing agent is carried out to keep in mind that the chemical will act as superior devulcanizing agent, easily available, low cost, smoothly penetrate into the crosslinked network in presence of carrier, multifunctional activity and eco‐friendly in nature. Consequently, the current research work is focused on the devulcanization of ground tire rubber (GTR) by way of a multifunctional devulcanizing agent, bis(3‐triethoxysilylpropyl)tetrasulfide. The uniqueness of the chemical agent is that it will devulcanize GTR mechanochemically and subsequently the so‐grown devulcanized rubber can facilitate the homogeneous silica dispersion into the revulcanized rubber compound. The degree of devulcanization and the devulcanized rubber quality is measured by the swelling experiment and Horikx theory. The experimental results clearly specified that the optimal devulcanization time is 40 min to obtain better‐quality of devulcanized rubber and enhanced mechanical and thermal performance of revulcanized rubber. The homogeneous silica dispersion in the rubber matrix is further supported by the scanning electron microscopy images. Ultimately, it was established that the as‐grown technology is suitable for rubber reclaiming, which provides to the advancement in the ecological sustainability.
Pharmacological modulation of conditioned fear in the fear-potentiated startle test: a systematic review and meta-analysis of animal studies
Authors: Groenink Lucianne , Verdouw P. Monika , Zhao Yulong , ter Heegde Freija , Wever Kimberley E. , Bijlsma Elisabeth Y. 
Published: January 2023

Abstract

Rationale and objectives
Fear conditioning is an important aspect in the pathophysiology of anxiety disorders. The fear-potentiated startle test is based on classical fear conditioning and over the years, a broad range of drugs have been tested in this test. Synthesis of the available data may further our understanding of the neurotransmitter systems that are involved in the expression of conditioned fear.

Methods
Following a comprehensive search in Medline and Embase, we included 68 research articles that reported on 103 drugs, covering 56 different drug classes. The systematic review was limited to studies using acute, systemic drug administration in naive animals.

Results
Qualitative data synthesis showed that most clinically active anxiolytics, but not serotonin-reuptake inhibitors, reduced cued fear. Anxiogenic drugs increased fear potentiation in 35% of the experiments, reduced fear potentiation in 29% of the experiments, and were without effect in 29% of the experiments. Meta-analyses could be performed for five drug classes and showed that benzodiazepines, buspirone, 5-HT1A agonists, 5-HT1A antagonists, and mGluR2,3 agonists reduced cued conditioned fear. The non-cued baseline startle response, which may reflect contextual anxiety, was only significantly reduced by benzodiazepines and 5-HT1A antagonists. No associations were found between drug effects and methodological characteristics, except for strain.

Conclusions
The fear-potentiated startle test appears to have moderate to high predictive validity and may serve as a valuable tool for the development of novel anxiolytics. Given the limited available data, the generally low study quality and high heterogeneity additional studies are warranted to corroborate the findings of this review.