bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
Authors: Rueda‐Carrasco Javier , Sokolova Dimitra , Lee Sang‐Eun , Childs Thomas , Jurčáková Natália , Crowley Gerard , De Schepper Sebastiaan , Ge Judy Z , Lachica Joanne I , Toomey Christina E , Freeman Oliver J , Hardy John , Barnes Samuel J , Lashley Tammaryn , Stevens Beth , Chang Sunghoe , Hong Soyon 
Published: August 2023

AbstractNeuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic studies in AD support that microglia act as potential cellular drivers of disease risk, but the molecular determinants of microglia‐synapse engulfment associated with neuronal hyperactivity in AD are unclear. Here, using super‐resolution microscopy, 3D‐live imaging of co‐cultures, andin vivoimaging of lipids in genetic models, we found that spines become hyperactive upon Aβ oligomer stimulation and externalize phosphatidylserine (ePtdSer), a canonical “eat‐me” signal. These apoptotic‐like spines are targeted by microglia for engulfment via TREM2 leading to amelioration of Aβ oligomer‐induced synaptic hyperactivity. We also show thein vivorelevance of ePtdSer‐TREM2 signaling in microglia‐synapse engulfment in the hAPP NL‐F knock‐in mouse model of AD. Higher levels of apoptotic‐like synapses in mice as well as humans that carry TREM2 loss‐of‐function variants were also observed. Our work supports that microglia remove hyperactive ePtdSer+synapses in Aβ‐relevant context and suggest a potential beneficial role for microglia in the earliest stages of AD.
Dynamics of SLC25A51 reveal preference for oxidized NAD+ and substrate led transport
Authors: Goyal Shivansh , Paspureddi Akhilesh , Lu Mu‐Jie , Chan Hsin‐Ru , Lyons Scott N , Wilson Crystal N , Niere Marc , Ziegler Mathias , Cambronne Xiaolu A 
Published: August 2023

AbstractSLC25A51 is a member of the mitochondrial carrier family (MCF) but lacks key residues that contribute to the mechanism of other nucleotide MCF transporters. Thus, how SLC25A51 transports NAD+ across the inner mitochondrial membrane remains unclear. To elucidate its mechanism, we use Molecular Dynamics simulations to reconstitute SLC25A51 homology models into lipid bilayers and to generate hypotheses to test. We observe spontaneous binding of cardiolipin phospholipids to three distinct sites on the exterior of SLC25A51's central pore and find that mutation of these sites impairs cardiolipin binding and transporter activity. We also observe that stable formation of the required matrix gate is controlled by a single salt bridge. We identify binding sites in SLC25A51 for NAD+ and show that its selectivity for NAD+ is guided by an electrostatic interaction between the charged nicotinamide ring in the ligand and a negatively charged patch in the pore. In turn, interaction of NAD+ with interior residue E132 guides the ligand to dynamically engage and weaken the salt bridge gate, representing a ligand‐induced initiation of transport.
Zur Verteidigung eines Leitbilds: Verzinsliches Darlehen nach § 488 Abs. 1 Satz 2 BGB und „Negativzinsen“
Authors: Binder Jens-Hinrich 
Published: August 2023

Zusammenfassung
In seiner Entscheidung vom 9. 5. 2023 zur darlehensrechtlichen Bewertung rechnerisch negativer Zinsleistungen infolge einer Zinsgleitklausel hat sich der XI. Zivilsenat des BGH erstmals im aktuellen Marktumfeld mit dem seit Jahren intensiv diskutierten Problemkreis der sog. Negativzinsen befasst, und zwar für einen Darlehensvertrag und mithin für das Aktivgeschäft der Kreditinstitute. Die vorliegende Anmerkung ordnet die zentralen Aussagen der Entscheidung ein und lotet ihre Reichweite auch für anders gelagerte Entscheidungen, insbesondere für die nach wie vor kontrovers diskutierte Zulässigkeit der Festlegung von Verwahrentgelten im Passivgeschäft, aus.
Ziele der Bankenregulierung – Ist mehr besser?
Authors: Neus Werner 
Published: August 2023

Zusammenfassung
Weit überwiegend sind Regulierungsziele nicht unmittelbar in den Gesetzestexten kodifiziert. Etwas mehr Klarheit verschafft der Blick in deren Begründungen. Ungeachtet einer Vielzahl hinzu gekommener Aufsichtsinstrumente und -methoden bleiben für lange Zeit die wesentlichen Ziele seit Einführung des KWG 1961 unverändert. Erst am jüngeren Ende zeigen sich vermehrte Anzeichen für eine Ausweitung von Regulierungszielen. Anhand einer Skizze von Desiderata für eine Regulierung (Notwendigkeit, Wirksamkeit und Effizienz) wird geprüft, ob Vorschriften de lege lata oder de lege feranda diesen Anforderungen genügen.
Geomorfología como herramienta de zonificación: Caso Chalaypampa, Angares – Huancavelica
Authors: León Ruiz Christian , Garay Vásquez Jair Alfredo , Garay Vera Henry Edinson , Goicochea Chávez Odilfo , Mendoza Rosales Tony , Torres Guerra Jesús Alberto 
Published: August 2023

La investigación corresponde al análisis geológico, geomorfológico y geodinámico del sector Chalaypampa como nueva área urbana para la reubicación de la centro político del distrito de Chincho, en la provincia de Angares, en el departamento de Huancavelica, por presentar peligro inminente para la integridad física y psicológica de las familias que habitan en la zona urbana actual de dicho distrito considerado como riesgo alto como consecuencia de una falla geológica identificada y su relación con intensas lluvias en la zona.
La metodología desarrollada es descriptiva correlacional, basado en la observación, que permite puntualizar y describir las características y fenómenos bajo contextos geológicos que se presentan en el entorno de investigación mientras se evalúan las variables que condicionan de cada espacio físico en el tiempo.
El distrito de Chincho fue calificado de riesgo alto, por el Gobierno Regional de Huancavelica, y verificado por el Instituto Geológico, Minero y Metalúrgico (INGEMMET), por lo es que de suma
importancia para la zona urbana del distrito una pronta reasignación en un sector que tenga las condiciones geológicas y geomorfológicas adecuadas para la planificación urbana.
Esta evaluación concluye que el sector de Chalaypampa presenta las condiciones necesarias para el reasentamiento considerando ciertas limitaciones que se presentan en la presente investigación.
Variation in physio-chemical attributes and WUE during growth and development of Pak choi (Brassica rapa L. subsp. chinensis L.) under different drip fertigation and mulching treatments
Authors: Singla P. , Sharda R. , Sharma S. , Gulati D. , Pandey K. , Navprem S. , Singh P.K. , Sharma A. 
Published: August 2023

AbstractIn the modern era, nutraceutical properties of horticultural crops are indispensable to determine their adaptability to different agro-ecological regions. The present study exploits the potential of mulches (P: plastic mulch; S: straw mulch; N: No mulch) in relation to drip irrigation (I1: 100%, I2: 80%, I3: 60% of crop evapotranspiration (Etc)), and fertigation (F1: 100%, F2: 80%, F3: 60% of recommended dose of fertilizer (RDF): 125 kg N, 62.5 Kg P2O5, 62.5 kg K2O per ha) on Pak choi at three maturity stages in the North West region of India. Plant fresh weight was the highest at 55 days after transplanting (DAT); however, maximum soil plant analysis development (SPAD) values were registered at 45 DAT. Antioxidant activity, FRAP, DPPH, phenols, flavanols, total sugars, ascorbic acid, free amino acids, and irrigation water use efficiency were observed significantly higher in plants grown on plastic mulch at different levels of irrigation and fertigation. It is envisioned that Pak choi plants had the highest nutritional value at 45 DAT from plots mulched with silver-black, irrigated at 80% Etc, and fertigated at 100% RDF. The nutrient enriched plants are used for green salad and as ingredients for the preparation of many recipes in the semi-arid and sub-tropic areas of India.
CANNIBALISM PERFORMANCE OF ASIAN REDTAIL CATFISH (Hemibagrus nemurus) FED RATION SUPPLEMENTED WITH DIFFERENT DOSES OF 17α-METHYLTESTOSTERONE
Authors: Heltonika Benny , Sudrajat Agus Oman , Junior Muhammad Zairin , Widanarni Widanarni , Suprayudi Muhammad Agus , Manalu Wasmen , Hadiroseyani Yani 
Published: August 2023

One of the obstacles in Asian redtail catfish hatchery is the high cannibalism incidence. Cannibalism is associated with aggressive behavior caused by hormonal metabolism especially of testosterone. The purpose of this study was to evaluate the effect of testosterone administration on the cannibalism incidence in the Asian redtail catfish juveniles. The experiment was conducted by rearing fish with initial length of 4.09±0.19 cm in 16 of 20 L aquariums with a density of 2 fish L-1. The experiment was designed with a completely randomized design with 4 treatments which were different level of 17α-methyltestosterone supplementation in feed, i.e., 0 mg kg-1 feed (A) as control, 7.5 mg kg-1 feed (B), 15 mg kg-1 feed (C), and 30 mg kg-1 feed (D). Each treatment has 4 replications. Fish fed experimental diet (40% protein) 4 times a day to satiation for 30 days. The parameters observed were type and index of cannibalism, aggressive behavior, survival rate, normal mortality, growth performance, hormones concentrations (estradiol, testosterone, and cortisol), and water quality. The results showed that cannibalism type II (the fish eaten completely or missing) and cannibalism index increased with the increasing doses of testosterone administration in the feed with the highest cannibalism incidence was 40.63%. The highest survival rate was found in treatment B (73.75±2.50%) and was not significantly different from the control treatment (69.38±2.39%). No differences in testosterone concentration and in the growth performance among the treatments. However, there was a trend of decrease in the estradiol concentration of Asian redtail catfish juveniles fed ration supplemented with the increasing doses of 17α-methyltestosterone. Based on the results obtained in this research, estradiol changed in the body's plasma, it appears that there was a role for plasma estradiol concentration in controlling cannibalism of Asian redtail catfish juveniles. It concluded that the testosterone administration affected the cannibalism incidence in the Asian redtail Catfish.
SUBLETHAL EFFECTS OF IMIDACLOPRID ON HAEMATOLOGICAL AND BIOCHEMICAL PROFILE OF FRESHWATER FISH, CYPRINUS CARPIO
Authors: Harkrishan, and Anil K. Tyor Jitender Kumar Bhardwaj, 
Published: August 2023

Imidacloprid is a commercialized Neonicotinoid pesticide, widely used to kill piercing and sucking types of insect pests in agriculture field. Due to its systemic nature and high water solubility, imidacloprid gradually reach and contaminate surrounding water bodies. The present study was planned to investigate the sublethal toxic impacts of pesticide imidacloprid on haematological and biochemical profile of freshwater fish, Cyprinus carpio. The fingerlings of Cyprinus carpio were exposed to three different sublethal concentrations of imidacloprid (7.8 ppm, 15.6 ppm and 23.4 ppm) for 30 days. Blood samples from all treatments were collected and used for hematological as well as biochemical diagnosis. During the trial period, haematological parameters like TEC, Hb and Hct were decreased significantly (P<0.05), whereas TLC count was found to be increased in imidacloprid treated fish. Similarly MCH count was lower but MCV was higher significantly as compared to control. In the biochemical analysis, plasma protein levels were significantly decreased in all the treatment groups when compared to control. Similar trends of significant decrease in the values of albumin and globulin was also reported. Thus, results of present study show that imidacloprid can cause remarkable alterations in the haematological and biochemical parameters of Cyprinus carpio.
The Future of Earth Imaging
Authors: Tsai Victor C. 
Published: August 2023

Abstract
Imaging of Earth’s interior has led to a large number of successful discoveries of plausible structures and associated geophysical processes. However, due to the limitations of geophysical data, Earth imaging has many trade-offs between the underlying features, and most approaches apply smoothing to reduce the effect of such trade-offs. Unfortunately, this smoothing often results in blurry images that are not clear enough either to infer the geologic processes of interest or to make quantitative inferences about the various geologic properties. Here, we first summarize some of the basic issues that make Earth imaging so difficult and explain how Earth imagers must choose between more open-ended discovery-oriented goals and more specific, scientific-inference-oriented goals. We discuss how the choice of the optimal imaging framework depends crucially on the desired goal, and particularly on whether plausible discovery or inference is the desired outcome. We argue that as Earth imaging has become more mature, sufficiently many plausible structures have been imaged that it is becoming more crucial for Earth imaging to serve the inference goal and would benefit from an inference-oriented imaging framework, despite the additional challenges in posing imaging problems in this manner. Examples of inference-oriented imaging frameworks are provided and contrasted with discovery-oriented frameworks. We discuss how the success of the various frameworks depends critically on the data quality and suggest that a careful balance must be struck between the ambition of the imager and the reality of the data. If Earth imaging is to move beyond presenting qualitatively plausible structures, it should move toward making quantitative estimates of the underlying geologic processes inferred through a self-consistent framework.
AN INVESTIGATION ON VIETNAM'S NON-PUBLIC UNIVERSITY EMPLOYEES’ WORK MOTIVATION
Authors: Giac Tri Nguyen 
Published: August 2023

The Mekong Delta is identified as one of the areas with low levels of education in Vietnam. In addition to the system of public universities, private universities are increasingly developing and making a significant contribution to improving the level of education in this area. The purpose of this study is to identify the factors influencing the work motivation of employees at non-public universities in the Vietnamese Mekong Delta. Data for the study came from 450 employees at five private universities in the Mekong Delta. The research was carried out in two stages: qualitative research and quantitative research. Additionally, the authors' choice of data analysis techniques included (1) evaluating the Cronbach's Alpha scale's reliability; (2) conducting an exploratory component analysis; and (3) performing a linear regression analysis. The study's findings demonstrated the wide range of factors that affect the job motivation of employees at five non-public universities in the Mekong Delta. The working environment was the most important factor, with a standardized beta regression coefficient of 0.282; welfare, regime, and policy came in second with an impact of 0.280; leadership style came in third with an impact of 0.212; training and promotion, and salary and bonus had an impact of 0.166 and 0.149, respectively. The author offers some suggestions to improve the job motivation of employees in Mekong Delta non-public universities based on the findings of this study.
Pelatihan Pemahaman Implementasi Teori Euclidean Distance dalam Metode K-Nearest Neighbour (K-NN) untuk Komputasi Cerdas bagi Siswa SMA
Authors: Mar'i Farhanna , Husenti Nadya , Brilian Rakhmadhan Rizki , Gumilang Agung 
Published: August 2023

SMA Muhammadiyah 8 Cerme adalah Sekolah Menengah Atas dengan tingkat kelas X, XI, dan XII yang memiliki jurusan Ilmu Alam dan Ilmu Sosial. Berdasarkan hasil wawancara yang dilakukan oleh tim Pengabdian kepada Masyarakat (PKM) Program Studi Teknik Informatika Universitas Muhammadiyah Gresik kepada pihak sekolah SMA Muhammadiyah 8 Cerme didapatkan informasi bahwa sekolah sedang berusaha mengaplikasikan kurikulum merdeka belajar kepada siswanya dan mereka belum pernah diperkenalkan implementasi rumus matematika dalam ilmu komputer khususnya teori komputasi cerdas. Adapun sasaran dari kegiatan PKM ini adalah siswa jurusan IPA kelas XI sebanyak 55 orang. Metode yang akan digunakan untuk kegiatan PKM ini adalah sosialisasi dan pelatihan tentang pentingnya mempelajari matematika khususnya rumus jarak dua titik atau teori Euclidean Distance beserta aplikasinya dalam Komputasi Cerdas menggunakan algoritme Klasifikasi yang merupakan bagian dari Data Mining yaitu K-Nearest Neighbour (KNN). Kegiatan PKM berlangsung selama 2 jam 30 menit dan dibagi dengan 3 sesi. Sesi pertama diisi dengan sosialisasi dan manualisasi teori Euclidean distance, lalu sesi kedua adalah implementasi K-NN dalam Komputasi Cerdas, kemudian sesi terakhir yaitu sesi 3 adalah pengisian post test untuk mengetahui pemahaman siswa terhadap materi yang telah disampaikan. Berdasarkan hasil post test menunjukkan bahwa siswa memahami teori Euclidean distance dan penerapannya pada komputasi cerdas menggunakan algoritme KNN dibuktikan dengan poin tertinggi untuk post test yang telah dijawab benar adalah 96,3 %.
Implementation of the Electrosurgical Checklist in a Podiatry Unit in Relation to a Case of Inadvertent Burns during Hallux Valgus Surgery
Authors: Córdoba-Fernández Antonio , Jiménez-Cristino María Dolores , Córdoba-Jiménez Victoria Eugenia , Mármol-García Francisco Javier 
Published: August 2023

Podiatric surgeons routinely use electrosurgical devices to cut and coagulate tissue during surgical procedures. Although advances in technology have made electrosurgery increasingly safer for patients and personnel, its use is still poorly understood by those using it and the hazards associated with its use still exist presently. Human error, direct or indirect transfer of electricity to a conductive device, or device malfunction can cause serious adverse events, including burns, electrical shocks, and or fires. Here, we report a rare case of a 43-year-old man who suffered severe burns during hallux valgus surgery. The surgeon and the nursing staff did not notice any injuries during the surgical intervention. This case highlights the need to implement tools to help health professionals improve patient safety during surgery. Based on the case herein reported, a specific checklist was implemented to prevent adverse events related to electrosurgery in our podiatric unit to reduce the risk of electrosurgical complications.
Optimization and Efficiency Enhancement of Modified Polymer Solar Cells
Authors: Khan Muhammad Raheel , Jarząbek Bożena 
Published: August 2023

In this study organic bulk heterojunction (BHJ) solar cell along with the spiro OMeTAD as a hole transport layer (HTL) and the PDINO as an electron transport layer (ETL) was simulated through the Solar Capacitance Simulator, one dimensional (SCAPS-1D) software to examine the performance of this type of polymer thin film organic solar cells. As an active layer the blend of polymer donor PBDB-T and non-fullerene acceptor ITIC-OE was used. Numerical simulation was performed by varying the thickness of HTL and active layer. Firstly, the HTL layer thickness was optimized to 50 nm, after that the active layer thickness varied up to 80 nm. These results of simulation demonstrated that the HTL thickness has rather little impact on efficiency while in the case of active layer thickness improves efficiency significantly. The temperature effect on the performance of solar cells was considered, by the simulation performed for temperature from 300 K up to 400 K and the efficiency of solar cell decreases with increasing temperature. Generally, polymer films usually are full of traps and defects, the density of defects (Nt) value was also introduced to the simulation, and it was confirmed that with the increasing of defect density (Nt), the efficiency of solar cell decreases. After thickness, temperature and defect density optimization, the reflection coating was also applied on it. It turned out that by introducing the reflection coating on the back side of solar cell, the efficiency increases by 2.5 %. Additionally, the positive effect of HTL and ETL doping on efficiency of this type of solar cells was demonstrated.
Analisis Kelayakan Usahatani Bunga Potong Krisan (Chrysanthemum Sp.)
Authors: Rachmawati Adinda , Soedarto Teguh , Syah Mirza Andrian 
Published: August 2023

Penelitian ini bertujuan untuk (1) Mengidentifikasi karakteristik petani usahatani bunga potong krisan (Chrysanthemum sp.), (2) Menganalisis faktor-faktor yang mempengaruhi tingkat produksi usahatani bunga potong krisan (Chrysanthemum sp.), (3) Menganalisis kelayakan usahatani bunga potong krisan (Chrysanthemum sp.) di Kecamatan Tutur Kabupaten Pasuruan. Jumlah sampel yang diambil sebnayak 51 responden menggunakan metode slovin yang diambil di Kecamatan Tutur Kabupaten Pasuruan yang dipilih secara purposive. Analisis data menggunakan analisis regresi linear berganda, R/C ratio, BEP, NPV, IRR dan PP. Hasil analisis menunjukkan bahwa Faktor luas lahan (X1), bibit (X2), pupuk (X3), pestisida (X4), dan tenaga kerja (X5) secara bersama-sama berpengaruh nyata terhadap jumlah produksi bunga potong krisan. Faktor luas lahan (X1), bibit (X2) dan tenaga kerja (X5) secara parsial berpengaruh nyata terhadap jumlah produksi bunga potong krisan di Kecamatan Tutur, Kabupaten Pasuruan.Pendapatan rata-rata selama tiga tahun sebesar 1.709.143.199. R/C ratio sebesar 2,9 nilai NPV sebesar 1.413.779.942, sedangkan IRR sebesar 119% dan PP sebesar 1 periode Hal ini menunjukkan bahwa usahatani bunga potong krisan layak untuk diusahakan.
A Hybrid Routing Protocol to Establish Communication in Mobility Cast using Mobility Pattern
Authors: Singh Ranjeet Kumar , Kumar Binod , Ahmad Mir Shahnawaz 
Published: August 2023

Abstract

Communication between two communities is very time consuming and difficult in the opportunistic network. Community is a collection of different nodes, grouping the nodes based on different behaviors and their property is called mobility pattern. Collecting the nodes based on the same mobility pattern is called mobility-cast. A community is a collection of different casts. Within the community it is very difficult to find a local as well as a global forwarder for the message transfer. It takes lots of time for searching the destination due to the lack of information for the path between the source and destination especially in heterogeneous environments in the sparse as well as the heavily crowded area. In a community message sent by a user U is delivered to the users in the other community B having the same cast and following the same mobility pattern like that of U (collectively named as Social friends). The paper presents a design of a robust protocol that helps in to control the relay, dropping, and unnecessary aborting the message. It also implements the synchronization between relaying and dropping of the message. The proposed mechanism reduces the overhead ratio and average latency in the network.