bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current vehicle emission standards will not mitigate climate change or improve air quality
Authors: Law Andrew Jiaxuan , Martinez-Botas Ricardo , Blythe Phil 
Published: April 2023

AbstractThe vehicle emissions testing programme was conducted by the UK Department of Transport in 2016 in response to emissions tampering exposed in the Volkswagen (VW) emissions scandal. The programme identified large emissions discrepancies between real-world and in-lab testing across a range of Euro 5 and Euro 6 diesel passenger vehicles. The large vehicle test fleet reflects the current challenges faced in controlling vehicle emissions. This paper presents the following findings: NOx emissions are altered due to exhaust gas recirculation mismanagement. A new Real-Life Emissions methodology is introduced to improve upon the current Real Driving Emissions standard. A large and concerning emissions divergence was discovered between the achieved NOx improvement and deterioration of CO2. The findings act as catalysts to improve vehicle emissions testing beyond standards established since the VW scandal, aiding in the development of better climate change mitigation strategies and bring tangible air quality improvements to the environment.
Development and validation of a questionnaire to test Chinese patients’ knowledge of inflammatory bowel disease
Authors: Xie Huabing , Zhang Jixiang , Liu Chuan , Yang Bingxiang , Dong Weiguo 
Published: April 2023

AbstractA good understanding of a disease facilitates patient-centered management. We aimed to develop and validate a questionnaire to assess inflammatory bowel disease (IBD)-related knowledge and analyze the factors affecting patients’ knowledge of IBD. We invited 15 experts to develop and modify an IBD knowledge questionnaires and 709 patients to test the reliability and validity of the questionnaires as well as analyze the factors related to the disease knowledge of patients with IBD. In internal consistency, Cronbach’s α coefficients for the common items, ulcerative colitis (UC), and Crohn’s disease (CD) knowledge questionnaires were 0.886, 0.89, and 0.886, respectively. In cross-item consistency, Spearman-Brown split coefficients of the common items, UC, and CD knowledge questionnaires were 0.843, 0.812, and 0.812, respectively. In time consistency, the test–retest reliability ICC was 0.862 (P < 0.001). The correlation between researcher scores, IBD-KNOW scores, and the original questionnaire scores was greater than 0.7 (P < 0.001). Multiple linear regression demonstrated that the factors, including disease type, age, body mass index, education level, income, treatment cost, duration of disease, and frequency of visits, affected the IBD patients’ knowledge of the disease (P < 0.05). The IBD knowledge questionnaires had good reliability and validity and, therefore, can be used to assess patient knowledge of the disease.
Imsidolimab, an anti-interleukin-36 receptor monoclonal antibody, for the treatment of generalized pustular psoriasis: results from the phase II GALLOP trial
Authors: Warren Richard B , Reich Adam , Kaszuba Andrzej , Placek Waldemar , Griffiths Christopher E M , Zhou Jihao , Randazzo Bruce , Lizzul Paul , Gudjonsson Johann E 
Published: April 2023

Abstract

Background
Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that can be severe, debilitating and life threatening. Uncontrolled activation of interleukin (IL)-36 proinflammatory activity may underlie the pathogenesis of GPP. Currently, GPP-specific treatment options are limited.

Objectives
To evaluate the efficacy and safety of the anti-IL-36 receptor antibody imsidolimab in patients with GPP.

Methods
In an open-label, single-arm, multiple-dose study, patients with GPP were treated with imsidolimab to assess clinical efficacy, tolerability and safety. Patients received an intravenous dose of imsidolimab 750 mg on day 1, followed by three subcutaneous doses of imsidolimab 100 mg administered on days 29, 57 and 85. The primary efficacy endpoint was the proportion of patients who achieved a clinical response at weeks 4 and 16 following treatment with imsidolimab, as measured by the Clinical Global Impression scale.

Results
Eight patients were enrolled and six completed the study. Responses were observed as early as day 3, most rapidly for pustulation relative to other manifestations of GPP, with continued and consistent improvement across multiple efficacy assessments at day 8, day 29 and through day 113. Most treatment-emergent adverse events (TEAEs) were mild to moderate in severity. No patient discontinued the study owing to a nonserious TEAE. Two patients experienced serious adverse events (SAEs); no deaths were reported.

Conclusions
Imsidolimab demonstrated a rapid and sustained resolution of symptoms and pustular eruptions in patients with GPP. It was generally well tolerated, with an acceptable safety profile, and is advancing to phase III trials. These data support the targeting of IL-36 signalling with a specific antibody – imsidolimab – as a therapeutic option for this severely debilitating condition.
A successful bridge to recovery with Impella 5.0 and subsequent hybrid cardiac resynchronization therapy in systemic right ventricle failure: a case report
Authors: Iwasaki Keiichiro , Nishii Nobuhiro , Akagi Satoshi , Ito Hiroshi 
Published: April 2023

Abstract

Background
Impella 5.0 is currently used as a temporary mechanical circulatory support device in cardiogenic shock (CS). However, Impella 5.0 implantation for the systemic right ventricle (sRV) has not been well documented.

Case summary
A 50-year-old man with atrial switch for dextro-transposition of the great arteries was transferred to our hospital for the treatment of embolic acute myocardial infarction of the left main trunk lesion with CS. To stabilize haemodynamics, we implanted Impella 5.0 via the left subclavian artery in the sRV. After optimal medical therapy initiation and gradual weaning of Impella 5.0, Impella 5.0 was successfully explanted. An electrocardiogram was obtained, which showed complete right branch block with a QRS duration of 172 ms. Acute invasive haemodynamic evaluation of cardiac resynchronization therapy (CRT) pacing showed that dP/dt increased from 497 to 605 mmHg/s (21.7% improvement), and hybrid cardiac resynchronization therapy defibrillator (CRTD) with a sRV epicardial lead was subsequently implanted. The patient was discharged without inotropic support.

Discussion
Coronary artery embolism is a rare but serious complication of dextro-transposition of the great arteries after atrial switch operations. Impella 5.0 implantation is a feasible bridge strategy for refractory CS due to sRV failure. Although CRT implantation in patients with sRV is controversial, an acute invasive haemodynamic evaluation can help assess its potential benefits.
Fabry disease due to D313Y variant with renal failure and possible cardiac involvement: a case report
Authors: Bei Evangelia , Antonopoulos Alexios S , Tsivgoulis Georgios , Vlachopoulos Charalambos 
Published: April 2023

Abstract

Background
This is a case report of a patient with Anderson–Fabry disease (AFD) due to the D313Y variant on the a-galactosidase A (GLA) gene on migalastat treatment and severe chronic kidney disease referred to our unit to assess possible cardiac involvement.

Case summary
A 53-year-old man with chronic kidney disease due to AFD and a medical history of revascularized coronary artery disease, chronic atrial fibrillation, and arterial hypertension was referred to our unit for evaluation of possible cardiac involvement in the context of AFD. Biochemical evaluation reported reduced serum alpha-galactosidase A activity and borderline abnormal serum lyso-Gb3 enzyme activity. The patient had also history of acroparesthesias, dermatological presentation of multiple angiokeratomas, severe kidney impairment with an estimated glomerular filtration rate (eGFR) of 30 mL/min/1.73m² by the age of 16, and microalbuminuria that cumulatively set the diagnosis of AFD. Transthoracic echocardiogram showed left ventricular concentric hypertrophy with left ventricular ejection fraction of 45%. Cardiac magnetic resonance showed findings in keeping with ischaemic heart disease (IHD), i.e. akinesia and subendocardial scarring of the basal anterior and the entirety of the septum and the true apex; in addition, there was severe asymmetrical hypertrophy of the basal anteroseptum (max 18 mm), evidence of low-grade myocardial inflammation, and mid-wall fibrosis of the basal inferior and inferolateral wall, suggesting a cardiomyopathic process–myocardial disease which could not be explained solely by IHD or well-controlled hypertension.

Discussion
This is the first case of possible cardiac involvement in a patient with AFD due to the D313Y variant. This case demonstrates the diagnostic challenges of cardiac involvement in AFD, especially in the presence of a concomitant underlying pathology.
Statins to prevent early cardiac dysfunction in cancer patients at increased cardiotoxicity risk receiving anthracyclines
Authors: Thavendiranathan Paaladinesh , Houbois Christian , Marwick Thomas H , Kei Tiffanie , Saha Sudipta , Runeckles Kyle , Huang Flora , Shalmon Tamar , Thorpe Kevin E , Pezo Rossanna C , Prica Anca , Maze Dawn , Abdel-Qadir Husam , Connelly Kim A , Chan Joyce , Billia Filio , Power Coleen , Hanneman Kate , Wintersperger Bernd J , Brezden-Masley Christine , Amir Eitan 
Published: April 2023

Abstract

Background and aims
Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD). We aimed to assess whether statins prevent decline in left ventricular ejection fraction (LVEF) in anthracycline-treated patients at increased risk for CTRCD.

Methods
In this multicenter double-blinded, placebo-controlled trial, patients with cancer at increased risk of anthracycline-related CTRCD (per ASCO guidelines) were randomly assigned to atorvastatin 40 mg or placebo once-daily. Cardiovascular magnetic resonance (CMR) imaging was performed before and within 4 weeks after anthracyclines. Blood biomarkers were measured at every cycle. The primary outcome was post-anthracycline LVEF, adjusted for baseline. CTRCD was defined as a fall in LVEF by &gt;10% to &lt;53%. Secondary endpoints included left ventricular (LV) volumes, CTRCD, CMR tissue characterization, high sensitivity troponin I (hsTnI), and B-type natriuretic peptide (BNP).

Results
We randomized 112 patients (56.9 ± 13.6 years, 87 female, and 73 with breast cancer): 54 to atorvastatin and 58 to placebo. Post-anthracycline CMR was performed 22 (13–27) days from last anthracycline dose. Post-anthracycline LVEF did not differ between the atorvastatin and placebo groups (57.3 ± 5.8% and 55.9 ± 7.4%, respectively) when adjusted for baseline LVEF (P = 0.34). There were no significant between-group differences in post-anthracycline LV end-diastolic (P = 0.20) or end-systolic volume (P = 0.12), CMR myocardial edema and/or fibrosis (P = 0.06–0.47), or peak hsTnI (P ≥ 0.99) and BNP (P = 0.23). CTRCD incidence was similar (4% versus 4%, P ≥ 0.99). There was no difference in adverse events.

Conclusions
In patients at increased risk of CTRCD, primary prevention with atorvastatin during anthracycline therapy did not ameliorate early LVEF decline, LV remodeling, CTRCD, change in serum cardiac biomarkers, or CMR myocardial tissue changes.

Trial registration
NCT03186404.
Navigating Community-Based Aged Care Services From the Consumer Perspective: A Scoping Review
Authors: Xie Yuchen , Hamilton Myra , Peisah Carmelle , Anstey Kaarin J , Sinclair Craig 
Published: April 2023

Abstract

Background and Objectives
The shift to consumer-directed aged care means that older adults need to play a more active role in navigating the complex aged care system for adequate health and social services. Challenges in the navigation process result in unmet needs and difficulty accessing available resources. This scoping review investigates how aged care navigation is conceptualized in literature and interrogates research on the experiences of older adults navigating community-based aged care services with or without support from their informal carers.

Research Design and Methods
This review follows the Joanna Briggs Institute methodological guidelines. PubMed, Scopus, and ProQuest were searched for relevant literature published from 2008 to 2021, supplemented by grey literature and manual reference list searching. Data were extracted using a predefined data-extraction table and synthesized with an inductive thematic analysis.

Results
The current conceptualization of aged care navigation focuses on the support provided to older adults, rather than actions taken by older adults themselves. Thematic analysis from the included studies (n = 26) revealed shared themes (lack of knowledge, social networks as information providers, complex care systems) among older adults and informal carers; unique challenges faced by older adults (difficulties with technology, waiting game), and informal carers (structural burden) in aged care navigation.

Discussion and Implications
Findings suggest the need to comprehensively assess individual circumstances including social networks and access to informal carers as predictors of successful navigation. Changes that reduce the complexity of the aged care system and improve coordination will relieve the structural burden experienced by consumers.
Fecal excretion ofCampylobacter jejuniby young dairy calves and the relationship with neonatal immunity and personality traits
Authors: Rapp Delphine , Schütz Karin E , Ross Colleen , Sutherland Mhairi A , Hempstead Melissa N , Hannaford Rina , Cave Vanessa M , Brightwell Gale 
Published: April 2023

AbstractAimsZoonotic pathogens in bovine herds are major concerns for human and animal health, but their monitoring in animals can be challenging in the absence of clinical signs. Our objective was to determine the association between fecal excretion of Campylobacter jejuni, neonatal immunity, and personality traits of calves.Methods and resultsForty-eight dairy calves were reared in three indoor pens from birth to 4 weeks of life. Microbial analyses of the fecal samples collected weekly revealed that the proportion of calves naturally contaminated with C. jejuni in each pen reached 70% after 3 weeks of life. High (&gt;16 g l−1) levels of IgG levels in the serum of neonatal calves were negatively (P = .04) associated with fecal detection of C. jejuni over the trial period. Calves that spent more time interacting with a novel object tended to be positive (P = .058) for C. jejuni.ConclusionsOverall, the findings indicate that the immunity of neonatal dairy animals and possibly the animal’s behavior may contribute to the fecal shedding of C. jejuni.
Spillovers in Childbearing Decisions and Fertility Transitions: Evidence from China
Authors: Rossi Pauline , Xiao Yun 
Published: April 2023

Abstract
This article uses China’s family planning policies to quantify and explain spillovers in fertility decisions. We test whether ethnic minorities decreased their fertility in response to the policies, although only the majority ethnic group, the Han Chinese, were subject to birth quotas. We exploit the policy rollout and variation in pre-policy age-specific fertility levels to construct a measure of the negative shock to Han fertility. Combining this measure with variation in the local share of Han, we estimate that a woman gives birth to 0.63 fewer children if the average completed fertility among her peers is exogenously reduced by one child. The fertility response of minorities is driven by cultural proximity with the Han and by higher educational investments, suggesting that spillovers operate through both social and economic channels. These results provide evidence that social multipliers can accelerate fertility transitions.
Ureteral transitional cell carcinoma with supraclavicular lymph node metastasis: a case report
Authors: Gupta Ankit , Mirpuri Lavesh , Hassan Hussain , Malik Faizan , Amtul Nasira 
Published: April 2023

Abstract
Metastasis to the supraclavicular lymph nodes usually originate from primary tumours in the head and neck, breast or abdomen. Infradiaphragmatic tumours very rarely metastasise to these nodes. Transitional cell carcinomas (TCCs), also termed urothelial carcinomas, account for ⁓90% of all ureteral cancers; exceptionally few cases have reported such cancers spreading to the supraclavicular fossae. We present the case of a 65-year-old male who was being investigated for gallstones and was subsequently found to have metastatic bony lesions and widespread adenopathy on magnetic resonance cholangiopancreatography. Initially, the primary cancer was an area of contention between clinicians, as radiologists suggested it was of urological origin, but the bladder multidisciplinary team felt the scans did not fulfil this notion. Ultimately, histological analysis confirmed the diagnosis of metastatic TCC.
Identification of Sutcliffiella horikoshii strains in an immunobiological pharmaceutical industry facility
Authors: de Miranda Rebeca Vitória da Silva Lage , da Costa Luciana Veloso , Albuquerque Letícia de Sousa , dos Reis Cristhiane Moura Falavina , Braga Lygia Maria Paulo da Silva , de Andrade Joyce Modesto , Ramos Juliana Nunes , Mattoso Josiane Machado Vieira , Forsythe Stephen James , Brandão Marcelo Luiz Lima 
Published: April 2023

Abstract
The pharmaceutical industry must comply with the requirements for good manufacturing practices to reduce inherent contamination risks in the production process. Bacillus and related genera are among the main bacterial isolated from clean areas, raw material, and products in the pharmaceutical industries, but the correct identification of these species is still a challenge. The aim of this study was to characterize by phenotyping, protein profiling, and 16S rRNA gene sequencing Sutcliffiellahorikoshii strains (n = 6) isolated from an immunobiological pharmaceutical facility, and to propose the reclassification of Bacillus tianshenii to the genus Sutcliffiella, and Sutcliffiella tianshenii sp. nov. The strains were characterized by VITEK®2, matrix-assisted laser desorption ionization-time of flight/mass spectrometry (MALDI-TOF/MS) using VITEK®MS, and 16S rRNA gene sequencing analysis. MALDI-TOF/MS did not identify any strains that were identified by 16S rRNA as S. horikoshii. VITEK®2 showed false-positive results, with misidentification as B. sporothermodurans (reclassified as Heyndrickxia sporothermodurans) and Geobacillus thermoleovorans. After MALDI-TOF/MS database expansion, with the creation of SuperSpectrum, the strains were correctly identified as S. horikoshii. This study is the first report of isolation of S. horikoshii strains from a pharmaceutical industry. More studies are necessary to better understand the ability of S. horikoshii to contaminate the environment and products.
Molecular detection and species identification of dermatophytes by SYBR-Green real-time PCR in-house methodology using hair samples obtained from dogs and cats
Authors: Spanamberg Andréia , Ravazzolo Ana Paula , Araujo Ricardo , Tomazi Natália , Fuentes Beatriz , Ferreiro Laerte 
Published: April 2023

Abstract
The classical dermatophytes diagnosis is based on mycological culture and microscopy observation both human and animal hair, skin, and nail samples. The aim of this work was to develop the new in-house real-time PCR with pan-dematophyte reaction for detection and identification of the main dermatophytes directly from hair samples, providing a simple and rapid diagnosis of dermatophytosis in dogs and cats.
An in-house SYBR-Green real-time PCR was designed and used for detecting a DNA fragment encoding chitin synthase 1 (CHS1). A total of 287 samples were processed by culture, microscopic examination with KOH 10%, and real-time PCR (qPCR) analysis. Melting curve analysis of the CHS1 fragment revealed to be reproducible, showing a single distinct peak for each species of dermatophyte, namely Trichophyton mentagrophytes, T. verrucosum, Microsporum canis, and Nannizzia gypsea (formerly M. gypseum). Then, out of the 287 clinically suspected cases of dermatophytosis, 50% were positive for dermatophytes by qPCR, 44% by mycological culture, and 25% by microscopic examination. Microsporum canis was identified in 117 samples tested by culture and 134 samples tested by qPCR, followed by N. gypsea in 5 samples (either tested by culture or qPCR) and T. mentagrophytes detected in 4 and 5 samples when tested by culture or qPCR, respectively. Overall, qPCR allowed the diagnosis of dermatophytosis in clinical samples. The results suggest this newly proposed in-house real-time PCR assay can be used as alternative diagnosis and rapid identification of dermatophytes frequently associated to clinical hair samples of dogs and cats.
WASP-131 b with ESPRESSO – I. A bloated sub-Saturn on a polar orbit around a differentially rotating solar-type star
Authors: Doyle L , Cegla H M , Anderson D R , Lendl M , Bourrier V , Bryant E , Vines J , Allart R , Bayliss D , Burleigh M R , Buchschacher N , Casewell S L , Hawthorn F , Jenkins J S , Lafarga M , Moyano M , Psaridi A , Roguet-Kern N , Sosnowska D , Wheatley P 
Published: April 2023

ABSTRACT
In this paper, we present observations of two high-resolution transit data sets obtained with ESPRESSO of the bloated sub-Saturn planet WASP-131 b. We have simultaneous photometric observations with NGTS and EulerCam. In addition, we utilized photometric light curves from TESS, WASP, EulerCam, and TRAPPIST of multiple transits to fit for the planetary parameters and update the ephemeris. We spatially resolve the stellar surface of WASP-131 utilizing the Reloaded Rossiter McLaughlin technique to search for centre-to-limb convective variations, stellar differential rotation, and to determine the star–planet obliquity for the first time. We find WASP-131 is misaligned on a nearly retrograde orbit with a projected obliquity of $\lambda = 162.4\substack{+1.3 \\ -1.2}^{\circ }$ . In addition, we determined a stellar differential rotation shear of α = 0.61 ± 0.06 and disentangled the stellar inclination ($i_* = 40.9\substack{+13.3 \\ -8.5}^{\circ }$ ) from the projected rotational velocity, resulting in an equatorial velocity of $v_{\rm {eq}} = 7.7\substack{+1.5 \\ -1.3}$ km s−1. In turn, we determined the true 3D obliquity of $\psi = 123.7\substack{+12.8 \\ -8.0}^{\circ }$ , meaning the planet is on a perpendicular/polar orbit. Therefore, we explored possible mechanisms for the planetary system’s formation and evolution. Finally, we searched for centre-to-limb convective variations where there was a null detection, indicating that centre-to-limb convective variations are not prominent in this star or are hidden within red noise.
aiolos – A multipurpose 1D hydrodynamics code for planetary atmospheres
Authors: Schulik Matthäus , Booth Richard A 
Published: April 2023

ABSTRACT
We present a new 1D multiphysics simulation code with use cases intended for, but not limited to, hydrodynamic escape problems of planetary atmospheres and planetary accretion models. Our formulation treats an arbitrary number of species as separated hydrodynamic fields, couples them via friction laws, allows for a multiband flux-limited radiation transport, and tracks ionization fronts in high-energy irradiation bands. Besides coupling various known numerical solution techniques together, we improve on the numerical stability of deep hydrostatic atmospheres by using a well-balanced scheme, hence preventing unphysical driving of atmospheric in- or outflow. We demonstrate the correct physical behaviour of the individual code modules and present a few simple, new applications, such as a proof-of-concept simulations of combined core-powered mass-loss and UV-driven atmospheric escape, along with a fully time-dependent core-collapse giant planet simulation. The multispecies nature of the code opens up the area of exploring simulations that are agnostic towards the dominant atmospheric species and can lead to implementations of advanced planetary evolution schemes.