bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Thresholds for Clinically Relevant Change in the Pediatric/Adolescent Shoulder Survey After Shoulder Instability Surgery: Factors Associated With Meaningful Improvement in Outcomes
Authors: Wallis-Lang Kendahl , Bastrom Tracey P. , Boutelle Kelly E. , Wagle Abigail , Pennock Andrew T. , Edmonds Eric W. 
Published: September 2023

Background: The pediatric/adolescent shoulder survey (PASS) score is a subjective measure of shoulder symptomology in younger patients. Purpose: To establish the minimal clinically important difference (MCID) and minimal detectable change (MDC) for the PASS score in adolescents after surgical treatment for shoulder instability. Study Design: Case series; Level of evidence, 4. Methods: Included were patients aged 12.5 to 23 years who underwent surgical treatment for shoulder instability and who had completed PASS forms preoperatively and at 3 months postoperatively. The MCID was established using an anchor-based approach, with the Single Assessment Numeric Evaluation (SANE) and shortened version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH) as anchors. Change in PASS score between anchor groups was determined using receiver operating characteristic curve analysis. MDC with 90% confidence (MDC90) was also calculated. Range of motion and strength data at 3-month follow-up were evaluated to identify the optimal postoperative PASS score. Factors associated with improvement in PASS score beyond the MDC90 and MCID were determined in a subset of patients with ≥6-month follow-up data. Results: A total of 95 patients were included. The mean PASS score improved significantly from preoperatively to postoperatively (57 ± 15 to 75 ± 16; P < .001). The anchor-based MCID ranged from 12.5 to 13.2 points, with an area under the receiver operating characteristic (AUC) curve of 0.87 for the SANE and 0.99 for the QuickDASH. The MDC90 was 16.5 points. The optimal PASS score at 3 months after surgery was ≥85 (AUC, 0.66). Shorter duration of symptoms, lower preoperative forward elevation, and higher preoperative external rotation were associated with improvement in PASS score above the MDC90 and/or MCID for the subset of patients (n = 25) with ≥6-month follow-up data. Increased number of suture anchors, less preoperative external rotation deficit, and number of previous dislocations had a moderate effect on improvement in outcomes. Conclusion: A postoperative increase in PASS score of ≥16.5 points had a 90% chance of being a true-positive change, while a score change of approximately 13 points was likely clinically relevant. The optimal PASS score after surgery was ≥85. Shorter duration of symptoms, preoperative range of motion, number of surgical anchors, and number of previous dislocations were associated with achieving a clinically relevant improvement in PASS score at minimum 6 months postoperatively.
Stabilization and Gap Formation of Adjustable Versus Fixed Primary ACL Repair With Internal Brace: An in Vitro Full-Construct Biomechanical Cadaveric Study
Authors: Bachmaier Samuel , Smith Patrick A. , Hammoud Sommer , Ritter Daniel , Hauck Oliver , Wijdicks Coen A. 
Published: September 2023

Background: A knotless, tensionable primary anterior cruciate ligament (ACL) repair system preloaded with an internal brace has been released. Currently, there is no biomechanical data on the stabilization and gap formation behavior of the adjustable system when compared with fixed repairs in human ACL tissue. Hypothesis: That knotless adjustable suture repair with an internal brace would provide overall higher construct stability and greater load share on the ACL with less gap formation compared with fixed repair. Study Design: Controlled laboratory study. Methods: Human cadaveric knees were utilized for internal braced ACL repair constructs (each group n = 16). Two fixed groups consisting of a single-cinch loop (SCL), cortical button (SCL group), and knotless suture-anchor (anchor group) were compared with an SCL-adjustable loop device (SCL-ALD) group. Testing was performed at 4 different peak loads (50, 150, 250, 350 N) over 4000 cycles at 0.75 Hz including suture repair preconditioning (10 cycles at 0.5 Hz) for SCL-ALD. Specimens were ultimately pulled to failure with a cut internal brace. The final loading situation of the construct and ACL repair with gap formation and ultimate strength were evaluated. Results: Peak elongation at various peak loads showed a significantly higher ( P < .001) stabilization of SCL-ALD when compared with both fixed groups. There was a significantly higher ( P < .001) load share of SCL-ALD, especially at lower loads (48% of 50 N), and the gap formation remained restricted up to 250 N. With only a little load share on the fixed constructs (<6%) at lower loads (50, 150 N), gap formation in these groups started at a load of 150 N, leading to significantly higher gaps ( P < .001). The ultimate failure load for SCL-ALD and anchor groups was significantly increased ( P < .001) as compared with SCL. The stiffness of SCL-ALD (62.9 ± 10.6 N/mm) was significantly increased ( P < .001). Conclusion: Internal braced knotless adjustable fixation for ACL repair with preconditioning of the suture repaired ligament increased the overall stabilization with higher load share on the ACL and restricted gap formation (<0.5 mm up to 350 N) compared with fixed suture repair. All internal braced repairs restored stability according to native ACL function. Clinical Relevance: Adjustable ACL repair improved the mechanical characteristics and reduced gap formation, but the overall clinical significance on healing remains unclear.
Comparison of EMG activity in the adductors during Copenhagen adductor exercise and Adductor slide in male ice hockey players
Authors: Olofsson Anton , Wörner Tobias , Eek Frida 
Published: September 2023

Objectives: The aim of this study is to estimate differences in muscle activity of the adductor longus- and adductor magnus muscle during the AS with different amounts of external resistance compared to CAE in male, adult, ice hockey players. Methods: This cross-sectional study compared muscular activity (EMG) during CAE and AS in a convenience sample of male ice hockey players. The players performed AS with different external loads and EMG readings was compared to the CAE. The main outcome was differences in mean %MVIC with CAE as a reference. Differences were compared using paired t-tests and standardized effect sizes (Cohen’s d) were calculated. Results: 21 injury free male ice hockey players participated in the study. We found a statistically significant lesser muscle activation during AS compared to CAE (p<0.05), Differences in mean %MVC during concentric contractions had a range between -60% (95% CI:-82%; -37%) and -28% (-51%; -6%) for the adductor longus, and between -67% (-93%; -41%) and -36% (-53%; -19%) for the adductor magnus. Differences in mean %MVC during eccentric contractions had a range between -70% (-88%; -53%) ad -62% (-78%; -46%) for the adductor longus and between -78% (-101%; -55%) and -68% (-88%; -48%) for the adductor magnus. The effect size was moderate to high (0.45-1-85) for all differences in mean. Conclusion: The AS produces significantly less muscle activation than the CAE, concentrically and eccentrically as well as with and without external loads.
The effect of Post Activation Potentiation in children’s jumping performance
Authors: Hjortsberg Samuel , Mattson Jesper , Jansson Daniel , Theos Apostolos 
Published: September 2023

Objectives: The objective of the present study was to investigate a) the potential effect of PAP in children’s jumping performance and b) the optimal time frame of the potential PAP effects in the same population Methods: Ten healthy male children (age: 12.2 ± 1.2; n= 7, pre-PHV and n= 3, post-PHV) conducted a single set of heavy resistance training (3RM leg press) followed by five maximal counter-movement-jump (CMJ) at different passive rest periods (1 min, 2 min, 4 min, 6 min, 8 min). Baseline 3RM leg press strength test, countermovement jump (CMJ), and peak height velocity (PHV) were assessed. Primary outcome: jump height (cm) pre and post-PAP. Results: No significant differences were observed between jumping heights pre- and post-PAP at any of the selected rest periods (1 min ES: 0.0; 2 min ES: 0.25; 4 min ES: 0.09; 6 min: ES: 0.03; 8 min ES: 0.15, p = 0.99). Pre vs. post-PAP jumping heights did not differ significantly even when participants were grouped according to peak height velocity (PHV) (pre-PHV: p = 0.97, ES: - 0.07 to 0.26 and post-PHV: p = 0.99, ES: - 0.11 to 0.37). Conclusion: The results indicate that a single set of a heavy lower-body resistance training protocol induces no significant PAP effect in healthy male preadolescent children, irrespective of the rest period used. Future studies with larger sample sizes are needed to confirm the results.
Treatment of esophageal leakages with the Microtech®-VAC-Stent: a monocentric early experience of three cases
Authors: Klose Michelle A. , Walldorf Jens , Damm Marko , Krug Sebastian , Klose Johannes , Ronellenfitsch Ulrich , Kleeff Joerg , Michl Patrick , Rosendahl Jonas 
Published: September 2023

Background: Endoscopic approaches in the treatment of transmural esophageal defects, either after esophageal resection or due to perforation, have demonstrated convincing feasibility. Surgical options are limited and associated with high morbidity and mortality rates. Currently, internal endoscopic drainage with pigtail stents, self-expanding metal stent (SEMS), or endoscopic vacuum therapy (EVT) are options for first-line treatment. Here, we report the outcome of the recently developed combination of SEMS and EVT using the endoscopic Microtech®-VAC-Stent (EVS). Methods: Between June and July 2022, three consecutive patients (one female and two males) with esophageal transmural defects were treated with the Microtech®-VAC-Stent. Two patients suffered from an anastomotic leak after oncologic gastroesophageal surgery, and one patient presented with esophageal perforation due to Boerhaave syndrome. Results: Three consecutive patients were successfully treated with EVS. In one patient, one EVS treatment was sufficient, whereas the other two patients needed two and six EVS exchanges. Exchanges were scheduled every 7 days and no procedural adverse events were observed. Conclusion: In line with the former case series, EVS therapy is a promising new approach for the treatment of esophageal leaks. Exchange of the EVS seems feasible every 7 days reducing interventions for the individual patient. Prospective studies comparing EVS with other endoscopic therapies are needed to define the best therapeutic approach.
Analysis of the effectiveness of remote intervention of patients affected by chronic diseases: A systematic review and meta-analysis
Authors: Rezende Demetrius Ruben Borges de , Neto Isadora Andrade , Iunes Denise Hollanda , Carvalho Leonardo César 
Published: September 2023

Objectives: The aim of the study was to verify the effectiveness of telemedicine in randomized controlled trials (RCTs) in terms of its influence on physical conditioning, quality of life, and health conditions in adults/elderly people affected by chronic diseases. Design: This was a systematic review and meta-analysis. Methods: The search covered RCTs published from 2011 to 2021 and was conducted using the PubMed, Embase, PEDro, Lilacs, and Cochrane Library databases, on volunteers of both sexes, that were rehabilitated, and/or monitored, and/or evaluated, specifically, via remote care. The extraction, quality of studies, and risk of bias were assessed using the RoB2 (risk of bias) tool, for analysis of the strength of evidence, the GRADE (Grading of Recommendations Assessment, Developing, and Evaluation) method was used, and for the preparation of meta-analysis was used at RevMan 5.4 (Review Manager) was used. Results: The database search identified 3949 potential articles for screening, 13 of which were eligible for the present systematic review, involving 1469 participants with chronic diseases (chronic obstructive pulmonary disease (COPD), asthma, heart failure, diabetes mellitus, and fibromyalgia). Through the meta-analysis, an advantage was identified for the remote intervention on physical conditioning ( p = 0.001), with an estimated effect of 0.29 (0.11, 0.46) and on health conditions ( p = 0.0004), –0.30 (–0.47, –0.14), while for quality of life, no significant difference was identified ( p = 0.90), 0.01 (–0.13, 0.14). Conclusion: Telemedicine has clinical effectiveness for the outcome of physical conditioning and general health conditions in adults with chronic diseases when compared to usual care without face-to-face intervention.
Simulation analysis of an adjusted gravity model for hospital admissions robust to incomplete data
Authors: Latruwe Timo , Van der Wee Marlies , Vanleenhove Pieter , Michielsen Kwinten , Verbrugge Sofie , Colle Didier 
Published: September 2023

Abstract
Background
Gravity models are often hard to apply in practice due to their data-hungry nature. Standard implementations of gravity models require that data on each variable is available for each supply node. Since these model types are often applied in a competitive context, data availability of specific variables is commonly limited to a subset of supply nodes.

Methods
This paper introduces a methodology that accommodates the use of variables for which data availability is incomplete, developed for a health care context, but more broadly applicable. The study uses simulated data to evaluate the performance of the proposed methodology in comparison with a conventional approach of dropping variables from the model.

Results
It is shown that the proposed methodology is able to improve overall model accuracy compared to dropping variables from the model, and that model accuracy is considerably improved within the subset of supply nodes for which data is available, even when that availability is sparse.

Conclusion
The proposed methodology is a viable approach to improve the performance of gravity models in a competitive health care context, where data availability is limited, and especially where a the supply nodes with complete data are most relevant for the practitioner.
Developing Family-Community Interactive program for the disabled older adults at home: a study protocol
Authors: Wang Peng , Niu Meilan , Chen Ying , Wang Shanshan , Wu Chuqiao , Zhao Di , Wang Panpan , Yang Huashan , Guo Panpan 
Published: September 2023

Abstract
Background
With an aging population and the influence of traditional culture, the number of disabled older adults at home is increasing. Meanwhile, their care needs are also increasing. The cooperation between family and community can effectively improve the quality of home care for the disabled older adults. At present, there is a lack of research on the interaction between family and community in home care for disabled older adults.

Methods
The aim of this study is to determine the experience and demands of the interaction for disabled older adults, family and community, construct an interaction program among disabled older adults, family and community, and improve the quality of life. From may 2022 to July 2022, This study will select disabled older adults families from seven communities in Henan provinces. The researchers, after training, will conduct semi-structured interview to collect research data. According to the integration results of qualitative research, the interactive program is constructed and revised using the Delphi expert consultation method. Then the participants will be selected to accept the intervention of the interactive program and evaluated through questionnaires.

Discussion
Both family and community play an important role in the care of the disabled older adults at home. There is some evidence indicating the benefits of cooperation between family and community on disabled older adults. This study will take a step further and constructs a interaction program about how to create a positive and interactive home-based older adults care environment.

Trial registration
Registered in the Chinese Clinical Trial Registry on April 19, 2021, number ChiCTR2100045584.
Turkish validity and reliability study of the nursing home adjustment scale
Authors: Varer Akpinar Ceren , Belice Tahir , Bolukbasi Selman , Mandiracioglu Aliye 
Published: September 2023

Abstract
Background
Adapting to a nursing home has a significant effect on facilitating the transition to a nursing home. However, a tailored nursing home adjustment scale for Turkish nursing home residents is not yet available. The purpose of this study was to translate the nursing home adjustment scale from English to Turkish and assess its reliability and validity in a sample of nursing home residents in Turkey.

Methods
A total of 202 older adults from four nursing homes were included in this study. The reliability of the Turkish nursing home adjustment scale was tested using Cronbach’s alpha values for internal consistency. Exploratory and confirmatory factor analyses were used to examine the factor structure, whereas correlation analysis was conducted for convergent validity.

Results
The Turkish version displayed satisfying internal consistency (Cronbach’s alpha = 0.88) and perfect convergent validity for life satisfaction (r = 0.482). The Turkish scale included five factors: difficulty fitting in, acceptance of new residence, emotional distress, depressed mood, and relationship development.

Conclusion
The findings indicate that the Turkish version of the scale is a valid and reliable tool for measuring the level of nursing home adjustment among older adults in Turkey.
Initial indicators for the prognosis of Acinetobacter Baumannii bacteremia in children
Authors: Hong Yi , Lin Xiaochen , Zhang Chunxu , Dong Xingqiang , Lu Meihua , Huang Saihu , Huang Lili , Su Chunmei , Bai Zhenjiang , Wu Shuiyan 
Published: September 2023

Abstract
Background
Risk factors related to mortality due to Acinetobacter baumannii (AB) bacteremia have been unveiled previously, but early clinical manifestations of AB bacteremia based on prognosis remain uncovered.

Methods
The demographic characteristics, clinical features, antibiotic susceptibility, and outcomes of 37 hospitalized children with laboratory-confirmed AB bacteremia from Suzhou, China, were collected and analyzed retrospectively.

Results
Of the 37 children with AB bacteremia included in this study, 23 were males and 14 were females, with a median age of 4.83 (0.60 to 10.15) years. Among the children, 18 died (48.65%, 18/37) and 19 survived (51.35%, 19/37). The dead group had a significantly higher incidence of respiratory failure (p = 0.008), shock (P = 0.000), MODS (p = 0.000), neutropenia (< 1.5 × 109/L) (p = 0.000) and serious neutropenia (< 0.5 × 109/L) (p = 0.000) than those in the survival group. The death group had significantly more invasive procedures (2 or more) than that in the survival group at 2 weeks before onset (p = 0.005). The proportion of MDR-AB in the death group was significantly higher than that in the survival group (p = 0.000), while the PICS score was significantly lower in the survival group than that in the death group (p = 0.000). There was no significant difference in effective antibiotic use within 24 h between these two groups (p = 0.295). Among the 37 children with bloodstream infection of AB, 56.76% (21/37) of the underlying diseases were hematological diseases and oncology. Among them, 17 (81.00%) were died in the hospital. The proportion of white blood cells (p = 0.000), neutrophils (p = 0.042), eosinophils (p = 0.029), the ANC (p = 0.000) and lymphocyte (p = 0.000), the NLR(p = 0.011), hemoglobin (p = 0.001), platelets (p = 0.000), prealbumin (P = 0.000), LDH (p = 0.017), blood gas pH (p = 0.000), and serum potassium (p = 0.002) in the death group were significantly lower than those in the survival group. However, CRP (p = 0.000) and blood glucose(p = 0.036) were significantly higher in the death group than those in the survival group. By further multivariate analysis, CRP [OR (95% CI): 1.022(1.003, 1.041), p = 0.021] and neutropenia [OR (95% CI): 21.634 (2.05, 228.313, p = 0.011] within 24 h of infection were independent risk factors for death in children with AB bacteremia. When CRP was higher than 59.02 mg/L, the sensitivity of predicting mortality was 88.9%, and the specificity was 78.9%. And the sensitivity and specificity of neutropenia for predicting mortality were 83.3% and 84.2%.

Conclusions
AB bacteremia has a high mortality in children, especially in patients with hematological diseases and oncology. Many early indicators were associated with poor prognosis, while elevated CRP and neutropenia were the independent predictors for the 30-day mortality of children with laboratory-confirmed AB bacteremia.
Wnt/β-catenin pathway is a key signaling pathway to trastuzumab resistance in gastric cancer cells
Authors: Kim Yuna , Bae Yoo Jin , Kim Jie-Hyun , Kim Hyunki , Shin Su-Jin , Jung Da Hyun , Park Hyojin 
Published: September 2023

Abstract
Background
Trastuzumab is the only approved target agent for the first-line treatment of human epidermal growth factor receptor-2 (HER-2) positive gastric cancer; however, trastuzumab resistance is a major problem in clinical practice. To comprehend the mechanism of trastuzumab resistance, we focused on the Wnt/β-catenin signaling pathway and its influence on the phenotypes and behavior of trastuzumab-resistant gastric cancer cells.

Methods
Trastuzumab-resistant NCI-N87R cells were established in vitro from the human gastric cancer cell line NCI-N87 by dose-escalating repeated trastuzumab treatment. We investigated the phenotypes of NCI-N87R cells, including Wnt signaling pathway activity. Gastric cancer organoid cells were incubated with complete medium and Wnt3a-depletion medium, and their resistance to trastuzumab was compared.

Results
NCI-N87R exhibited stemness and epithelial-mesenchymal transition (EMT)-like phenotypes, along with decreased levels of the epithelial marker E-cadherin and increased levels of the mesenchymal markers Vimentin and Snail along with an increased Wnt signaling pathway activity. When gastric cancer cells were incubated in Wnt3a-conditioned medium. Wnt signaling pathway activity and resistance to trastuzumab increased. Gastric cancer patient-derived organoids incubated in Wnt3a-depletion medium were more susceptible to dose-dependent inhibition of cell viability by trastuzumab than those incubated in complete medium.

Conclusions
Trastuzumab-resistant gastric cancer cells exhibited EMT-like phenotype, and trastuzumab resistance was promoted by the Wnt/β-catenin signaling pathway. The Wnt/β-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Multifocal epithelial hyperplasia confined to the interdental papilla of an adult Chinese man: a rare case report and literature review
Authors: Wang Qianting , Xu Lehan , Li Xiaojun , Yu Mengfei , Chen Qianming 
Published: September 2023

AbstractBackgroundMultifocal epithelial hyperplasia (MEH), or focal epithelial hypertension (FEH), or Heck’s disease, is an uncommon, benign oral mucosal disease associated with human papillomavirus infection. It is mostly observed in indigenous populations of the world, and has been rarely reported in China. However, previous research suggested there might be a greater prevalence of MEH in the Chinese population. While predominantly involves the lips, buccal mucosa and tongue, MEH was occasionally reported to affect the hard palate and gingiva as well.Case presentationThis paper reports a case of extensive MEH lesions that confined to the interdental papilla of a Chinese male without detection of HPV, and summarizes the published gingiva-involved MEH reports from 1966 until present. The lesions were excised with an Er: YAG laser after scaling and root planning, no recurrence was observed after 6-month follow-up.ConclusionsThe present report illustrates the need for clinicians to be aware of rare presentations of MEH to facilitate a prompt diagnosis and proper management. More reports are encouraged to determine a correct prevalence rate of MEH in China.