bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of built, social, and economic environments on adolescent obesity and related health behaviors
Authors: Prados María J. , Nicosia Nancy , Datar Ashlesha 
Published: March 2023

AbstractObjectiveThis study aimed to estimate the effects of the built, social, and economic environments on adolescent obesity and related behaviors.MethodsExploiting quasi‐exogenous variation in military families' geographic location, this study estimated intent‐to‐treat models of the association between the assigned installation's county environments and adolescents' (mean age 13.5 years) self‐reported and model‐corrected BMI, overweight or obesity status, and self‐reported diet and exercise. Three indices for the built, social, and economic environments characterized county‐level environments (higher value implies more advantageous environments) based on 19 indicators. Multivariate linear and logistic models were estimated on the full sample (N = 1111) and on subsamples with greater exposure based on time (n = 682) and off‐installation residence (n = 604).ResultsExposure to more advantageous built environments for more than 2 years was associated with lower probabilities of obesity (−0.18; 95% CI: −0.34 to −0.026) and overweight or obesity (−0.34; 95% CI: −0.56 to −0.12) and was associated with lower BMI z scores (−0.76; 95% CI: −1.45 to −0.02). Results for adolescents living off‐installation were similar. More advantageous built environments were also associated with lower consumption of unhealthy foods, but not with physical activity. Social and economic environments were not associated with any outcomes.ConclusionsThe built environment, but not social and economic environments, was a strong predictor of adolescents' BMI, overweight or obesity status, and eating behaviors.
Needs Assessment of Gender‐Affirming Face, Neck, and Voice Procedures and the Role of Gender Dysphoria
Authors: Ziltzer Ryan S. , Lett Elle , Su‐Genyk Peiyi , Chambers Tamara , Moayer Roxana 
Published: March 2023

AbstractObjectiveTo assess the needs of transgender and nonbinary (TNB) adults for gender‐affirming face, neck, and voice procedures.Study DesignCross‐sectional survey.SettingOnline, February to May 2022.MethodsPrimary outcomes included utilization of otolaryngologists and speech‐language pathologists; gender dysphoria felt from the face, neck, and voice self‐reported on a 0 to 10 numeric rating scale (0 = no dysphoria, 10 = unbearable); and desire for various gender‐affirming face, neck, and voice procedures. We used ordinal logistic and linear regression to assess relationships between site‐specific dysphoria and the desire for relevant procedures.ResultsTNB participants (N = 234) infrequently sought gender‐affirming care with speech‐language pathologists (23%), facial plastic surgeons (8%), or laryngologists (3%). Participants experienced the strongest dysphoria from the voice (median 7/10), jawline/chin (4/10), and neck (3.5/10). Transmasculine and nonbinary participants typically seeking masculinization (n = 83) frequently desired voice therapy (want = 35%, had = 8%). Transfeminine and nonbinary participants typically seeking feminization (n = 145) frequently desired voice therapy (want = 52%, had = 23%), chondrolaryngoplasty (want = 45%, had = 5%), and hair removal/electrolysis (want = 43%, had = 44%). Many desired at least 1 facial feminization surgery procedure (65%), especially mandible reduction (want = 42%, had = 3%), rhinoplasty (want = 41%, had = 1%), and forehead reduction (want = 37%, had = 4%). Dysphoria ratings were associated with desiring relevant procedures (p < .05 for all), notably voice therapy (odds ratio [OR] = 1.50), chondrolaryngoplasty (OR = 1.46), mandible reduction (OR = 1.38), rhinoplasty (OR = 1.59), and forehead reduction (OR = 1.82).ConclusionGender dysphoria from the face, neck, and voice can be severe for TNB people and is associated with the desire for gender‐affirming procedures. The high demand yet low reported access to these procedures highlights the need for providers of gender‐affirming face, neck, and voice care.
Insecticide resistance compromises the control of Aedes aegypti in Bangladesh
Authors: Al‐Amin Hasan Mohammad , Gyawali Narayan , Graham Melissa , Alam Mohammad Shafiul , Lenhart Audrey , Hugo Leon E , Rašić Gordana , Beebe Nigel W , Devine Gregor J 
Published: March 2023

AbstractBACKGROUNDWith no effective drugs or widely available vaccines, dengue control in Bangladesh is dependent on targeting the primary vector Aedes aegypti with insecticides and larval source management. Despite these interventions, the dengue burden is increasing in Bangladesh, and the country experienced its worst outbreak in 2019 with 101 354 hospitalized cases. This may be partially facilitated by the presence of intense insecticide resistance in vector populations. Here, we describe the intensity and mechanisms of resistance to insecticides commonly deployed against Ae. aegypti in Dhaka, Bangladesh.RESULTSDhaka Ae. aegypti colonies exhibited high‐intensity resistance to pyrethroids. Using CDC bottle assays, we recorded 2–24% mortality (recorded at 24 h) to permethrin and 48–94% mortality to deltamethrin, at 10× the diagnostic dose. Bioassays conducted using insecticide–synergist combinations suggested that metabolic mechanisms were contributing to pyrethroid resistance, specifically multi‐function oxidases, esterases, and glutathione S‐transferases. In addition, kdr alleles were detected, with a high frequency (78–98%) of homozygotes for the V1016G mutation. A large proportion (≤ 74%) of free‐flying and resting mosquitoes from Dhaka colonies survived exposure to standard applications of pyrethroid aerosols in an experimental free‐flight room. Although that exposure affected the immediate host‐seeking behavior of Ae. aegypti, the effect was transient in surviving mosquitoes.CONCLUSIONThe intense resistance characterized in this study is likely compromising the operational effectiveness of pyrethroids against Ae. aegypti in Dhaka. Switching to alternative chemical classes may offer a medium‐term solution, but ultimately a more sustainable and effective approach to controlling dengue vectors is required. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A cluster of heritable pulmonary arterial hypertension cases in a family with all three siblings carrying the same novel AQP1 c.273C>G variant‐a case report
Authors: Liang Kae‐Woei , Chang Sheng‐Kai , Chen Yu‐Wei , Tsai Wan‐Jane , Wang Kuo‐Yang 
Published: March 2023

AbstractApproximately 25%–30% of patients diagnosed with idiopathic pulmonary arterial hypertension (PAH) have a clustered underlying Mendelian genetic cause and should be classified as heritable PAH (HPAH). The sixth World Symposium on Pulmonary Hypertension listed AQP1 as a PAH‐related gene. AQP1 and its protein product Aquaporin‐1 (AQP1) are found in abundance within pulmonary artery smooth muscle cells. Here, we report a family affected by HPAH with all three siblings carrying the same novel missense variant of AQP1 c.273C>G (p.Ile91Met). The youngest brother and the older sister both had dyspnea and edema and were diagnosed with HPAH about 10 years ago. In 2021, they received genetic tests that revealed all three siblings carried the same novel variant of AQP1 (c.273C>G). The brother in between these two siblings, although originally claimed to be asymptomatic, raised awareness. He then sought medical examination and confirmed the diagnosis of HPAH as well. This report on all three siblings carrying the same novel variant of AQP1 (c.273C>G) highlighted the importance of genetic testing and counseling for family members when PAH was first detected.
Difficult removal after bronchial filling of an endobronchial Watanabe spigot with N‐butyl‐2‐cyanoacrylate for intractable pneumothorax: A case report
Authors: Nakamura Tomoaki , Ro Shosei , Morita Chie , Kanomata Naoki , Kitamura Atsushi 
Published: March 2023

AbstractA 52‐year‐old man developed a right pneumothorax during treatment for COVID‐19. In a previous case report concerning this patient, his recovery was achieved through implanting four endobronchial Watanabe spigots (EWS) in the right B1 and B3 in two phases and spraying N‐butyl‐2‐cyanoacrylate (NBCA). One year later, EWS removal was planned. He was intubated under bronchoscopic guidance, and the right upper lobe was observed. The right B1 and B3 inlets were found to be covered with granuloma. Despite the presence of a nylon thread for easy retrieval and partial debridement of the granulation, removal of the implanted EWS in the right B1 and B3 using grasping forceps, basket forceps, and two types of balloons under fluoroscopic guidance was challenging. NBCA spraying is a possible cause of foreign body granuloma formation. Therefore, careful consideration of the indications for the combined EWS‐NBCA procedure is necessary.
Emissions trading scheme and green development in China: Impact of city heterogeneity
Authors: Zhai Xueqi , An Yunfei , Shi Xunpeng , Cui Hongqiao 
Published: March 2023

AbstractThe emissions trading scheme (ETS) is a key policy tool for reducing carbon emissions and combating climate change but may cause unintended social‐economic consequences. Clarifying the role of city heterogeneity can contribute to improving ETS policy and informing green development roadmaps. Using panel data of 274 Chinese prefecture‐level cities, the heterogeneous impacts of ETS on city green development efficiency (CGDE) were assessed by the difference in difference in difference (DDD) method. The results show that: the ETS significantly advances China's CGDE, mainly through inducing cities' green innovation. More insightfully, the ETS policy has more significant positive effects on the cities in the eastern region, high economic development, resource abundance, and good environmental governance than otherwise. The study suggests that designing the ETS should incorporate the cities' heterogeneous characteristics to accelerate green development through green innovation and cover more regions and industries.
Acoustic Trapping: An Emerging Tool for Microfabrication Technology
Authors: Yin Chengying , Jiang Xingyu , Mann Stephen , Tian Liangfei , Drinkwater Bruce W. 
Published: March 2023

AbstractThe high throughput deposition of microscale objects with precise spatial arrangement represents a key step in microfabrication technology. This can be done by creating physical boundaries to guide the deposition process or using printing technologies; in both approaches, these microscale objects cannot be further modified after they are formed. The utilization of dynamic acoustic fields offers a novel approach to facilitate real‐time reconfigurable miniaturized systems in a contactless manner, which can potentially be used in physics, chemistry, biology, as well as materials science. Here, the physical interactions of microscale objects in an acoustic pressure field are discussed and how to fabricate different acoustic trapping devices and how to tune the spatial arrangement of the microscale objects are explained. Moreover, different approaches that can dynamically modulate microscale objects in acoustic fields are presented, and the potential applications of the microarrays in biomedical engineering, chemical/biochemical sensing, and materials science are highlighted alongside a discussion of future research challenges.
NIR‐II Imaging‐Guided Mitochondrial‐Targeting Organic Nanoparticles for Multimodal Synergistic Tumor Therapy
Authors: Yang Sha , Sun Bin , Liu Fen , Li Na , Wang Minghui , Wu Peixian , Wu Gui‐long , Fang Huilong , He Yuxuan , Zhou Wei , Xiao Hao , Tan Xiaofeng , Tang Li , Zhu Shoujun , Yang Qinglai 
Published: March 2023

AbstractEffectively interfering energy metabolism in tumor cells and simultaneously activating the in vivo immune system to perform immune attacks are meaningful for tumor treatment. However, precisely targeted therapy is still a huge challenge. Herein, a mitochondrial‐targeting phototheranostic system, FE‐T nanoparticles (FE‐T NPs) are developed to damage mitochondria in tumor cells and change the tumor immunosuppressive microenvironment. FE‐T NPs are engineered by encapsulating the near‐infrared (NIR) absorbed photosensitizer IR‐FE‐TPP within amphiphilic copolymer DSPE‐SS‐PEG‐COOH for high‐performing with simultaneous mitochondrial‐targeting, near‐infrared II (NIR‐II) fluorescence imaging, and synchronous photothermal therapy (PTT) /photodynamic therapy (PDT) /immune therapy (IMT). In tumor treatment, the disulfide in the copolymer can be cleaved by excess intracellular glutathione (GSH) to release IR‐FE‐TPP and accumulate in mitochondria. After 808 nm irradiation, the mitochondrial localization of FE‐T NPs generated reactive oxygen species (ROS), and hyperthermia, leading to mitochondrial dysfunction, photoinductive apoptosis, and immunogenic cell death (ICD). Notably, in situ enhanced PDT/PTT in vivo via mitochondrial‐targeting with FE‐T NPs boosts highly efficient ICD toward excellent antitumor immune response. FE‐T NPs provide an effective mitochondrial‐targeting phototheranostic nanoplatform for imaging‐guided tumor therapy.
Construction of Covalent Organic Framework Nanofiber Membranes for Efficient Adsorption of Antibiotics
Authors: Zhao Xiaojia , Li Qun , Pachfule Pradip , Wang Zhiya , Liu Shiyin , Wu Weijian , Wu Mingxing , Thomas Arne 
Published: March 2023

AbstractTechniques beyond crystal engineering are critical for manufacturing covalent organic frameworks (COFs) and to explore them for advanced applications. However, COFs are normally obtained as insoluble, unmeltable, and thus nonprocessible microcrystalline powders. Therefore, it is a significant challenge to implement COFs into larger architectures and structural control on different length scales. Herein, a facile strategy is presented to prepare flexible COF nanofiber membranes by in‐situ growth of COFs on polyacrylonitrile (PAN) nanofiber substrates via a reversible polycondensation‐termination approach. The obtained PAN@COF nanofiber membranes with vertically aligned COF nanoplates combine a large functional surface with efficient mass transport, thus making it a promising adsorbent, for example, for water purification. The antibiotic pollutant ofloxacin (OFX) is removed from water with a superior absorption capacity of ≈236 mg g−1 and removal efficiency as high as 98%. The here presented in‐situ growth of COFs on nanofiber membranes can be extended to various Schiff base‐derived COF materials with different compositions, providing a highly efficient way to construct flexible COF‐based membranes for several applications.
Application of Carbon Fiber‐Reinforced Ceramic Composites in Active Thermal Protection of Advanced Propulsion Systems: A Review
Authors: Jing Tingting , Xin Yuepeng , Zhang Liang , Sun Xing , He Chunwang , Wang Jiachen , Qin Fei 
Published: March 2023

AbstractThermal protection is one of the crucial issues for the advanced propulsion systems of Reusable Launch Vehicles. New service requirements for materials, such as high strength, low density, low thermal expansion, high thermal stability, etc., are raised for the thermal structure with the increasing demand of flight Mach numbers and thrust‐to‐weight ratio. Carbon fiber‐reinforced ceramic composites, which generally meet the aforementioned requirements, show great potential for various applications and they have been widely applied in the thermal protection for hypersonic vehicles. This paper gives a comprehensive and systematic review of current research status for carbon fiber‐reinforced ceramic composites applied in the thermal structure of advanced propulsion systems. Three aspects are presented and discussed: the ceramic composites fabrication and the property characterization, the thermal performance of composite thermal structure used in practical engines, and the numerical methods for predicting mechanical and thermal properties of composites as well as the physicochemical phenomenon in the cooling channels. Firstly, the main manufacturing processes for the carbon‐reinforced ceramic composites are presented and the corresponding advantages and disadvantages are analyzed. The high‐temperature oxidation and ablation behaviors of composites are demonstrated and the improvement of oxidation and ablation resistance by introducing the ultra‐high‐temperature ceramics into C/C composites is discussed in detail. Then, several typical applications of carbon fiber‐reinforced ceramic composites (mainly C/SiC), including the work of RCI, JAXA and NASA, have been reviewed and analyzed. After that, the current research status of macroscale equivalent and multiscale numerical methods for predicting the mechanical and thermal properties of composites as well as the complex physicochemical phenomenon occurring in hydrocarbon fuels are sorted out. Finally, several potential prospects are pointed out for the future research on the thermal protection of advanced propulsion systems based on the carbon fiber‐reinforced ceramic composites.
Fluoroalkyl Sulfoximines for Versatile Photocatalytic Radical Fluoroalkylations
Authors: Koike Takashi 
Published: March 2023

AbstractFluoroalkyl sulfoximines, which serve as electron‐accepting fluoroalkyl radical sources, are easy‐to‐handle, solid, and bench‐stable chemicals. Fluoroalkyl radicals can be generated from sulfoximine reagents using strong one‐electron injectors, such as a highly reducing photoredox catalyst in the excited state. Our group has developed photocatalytic radical di‐ and mono‐fluoromethylation and α‐monofluoroalkylation of olefins with the corresponding fluoroalkyl sulfoximines. In this personal account, appropriate combinations of fluoroalkyl sulfoximines and photoredox catalysts, leading to successful radical fluoroalkylation, have been discussed.
Alkynyl Acylazolium: A Versatile 1,3‐Bielectrophilic 3C‐Synthon in NHC‐Organocatalysis
Authors: Gao Jian , Zhang Simiao , Du Ding 
Published: March 2023

AbstractN‐Heterocyclic carbene (NHC) organocatalysis has emerged as a powerful tool in the field of modern organic synthesis especially in the asymmetric construction of various cyclic skeletons. As an emerging NHC‐bound 1,3‐bielectrophilic intermediate, alkynyl acylazolium has drawn substantial attention in recent years, and has been used as a versatile 3C‐synthon in synthesizing valuable organic molecules since its discovery. In this review, focused on the different pathways for the formation of alkynyl acylazoliums from different precursors like alkynoic esters, alkynoic acids and ynals, the recent advances in the transformations and applications of alkynyl acylazoliums pioneered or developed over the last decade under NHC‐catalysis were summarized comprehensively. At the same time, the outlook for further investigation and exploration of novel reaction modes for alkynyl acylazoliums in the future was also discussed.
Comparison of two strategies for the management of postoperative recurrence in Crohn’s disease patients with one clinical risk factor: A multicentre IG‐IBD study
Authors: Dragoni Gabriele , Castiglione Fabiana , Bezzio Cristina , Pugliese Daniela , Spagnuolo Rocco , Viola Anna , Cocomazzi Francesco , Aratari Annalisa , Savarino Edoardo Vincenzo , Balestrieri Paola , Onali Sara , Viganò Chiara , Ribaldone Davide Giuseppe , Innocenti Tommaso , Testa Anna , Saibeni Simone , Privitera Giuseppe , Milla Monica , Armuzzi Alessandro , Fantini Massimo Claudio , Fiorino Gionata 
Published: March 2023

AbstractBackgroundThe management of postoperative recurrence (POR) in Crohn's disease (CD) after ileo‐colonic resection is a highly debated topic. Prophylactic immunosuppression after surgery is currently recommended in the presence of at least one clinical risk factor.ObjectiveOur aim was to determine whether early immunosuppression can be avoided and guided by endoscopy in CD patients with only one risk factor.MethodsCD patients with only one risk factor for POR, including previous intestinal resection, extensive small intestine resection (>50 cm), fistulising phenotype, history of perianal disease, and active smoking, were retrospectively included. Two groups were formed based on whether immunosuppression was started immediately after surgery (“prophylaxis group”) or guided by endoscopy (“endoscopy‐driven group”). Primary endpoints were rates of any endoscopic recurrence (Rutgeerts ≥ i2a) and severe endoscopic recurrence (i4) within 12 months after surgery. Secondary outcomes were clinical recurrence rates at 6, 12 and 24 months after surgery.ResultsA total of 195 patients were enroled, of whom 61 (31.3%) received immunoprophylaxis. No differences between immunoprophylaxis and the endoscopy‐driven approach were found regarding any endoscopic recurrence (36.1% vs. 45.5%, respectively, p = 0.10) and severe endoscopic recurrence (9.8% vs. 15.7%, respectively, p = 0.15) at the first endoscopic evaluation. Clinical recurrence rates were also not statistically different (p = 0.43, p = 0.09, and p = 0.63 at 6, 12, and 24 months, respectively).ConclusionsIn operated CD patients with only one risk factor for POR, immediate immunoprophylaxis does not decrease the rate of early clinical and endoscopic recurrence. Prospective studies are needed to confirm our results.
Optical biosensing systems for a biological living body
Authors: Yan Tao , Guo Changfa , Wang Chunsheng , Zhu Kai 
Published: March 2023

AbstractWith the development of technology, biosensors are increasingly used in the biomedical field. Due to the high sensitivity of optical signals, good stability, high signal‐to‐noise ratio, and different spectral characteristics of different analytes, optical biosensors can achieve direct and real‐time detection of analytes with high specificity compared with traditional analytical techniques. In view of the rapid development of optical biosensors for in vivo applications and their promising future, we have attempted to summarize the working principles and recent advances in application in humans, with the aim of helping readers to gain an in‐depth and detailed understanding of optical biosensors developed in recent years for applications in the biological living body. In this review, we focus on some of the current widely used and promising optical biosensors, including colorimetric biosensors, fluorescence biosensors, and surface‐enhanced‐Raman‐scattering‐based biosensors. The working principles for each type of optical biosensor are concisely described and the application of the biosensor in the living body is summarized by category. We conclude by looking at the prospects of in vivo applications of optical biosensors.