bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s experience of the health information process involving a digital information tool before commencing radiation therapy for breast cancer: a deductive interview study
Authors: Grynne Annika , Wångdahl Josefin , Fristedt Sofi , Smith Frida , Browall Maria 
Published: February 2023

Abstract
Background
Women due to commence radiation therapy for breast cancer frequently request information throughout and after the treatment as a means to reduce distress. Nevertheless, the provision of information to meet individual needs from their level of health literacy is often overlooked. Thus, women’s information needs are often unmet, leading to reports of discontent. Internet and digital information technology has significantly augmented the available information and changed the way in which an individual person accesses and comprehends information. As health information is no longer explicitly obtained from healthcare professionals, it is essential to examine the sequences of the health information process in general, and in relation to health literacy. This paper reports on qualitative interviews, targeting women diagnosed with breast cancer who were given access to a health information technology tool, Digi-Do, before commencing radiation therapy, during, and after treatment.
Methods
A qualitative research design, inspired by the integrated health literacy model, was chosen to enable critical reflection by the participating women. Semi-structured interviews were conducted with 15 women with access to Digi-Do, in addition to receiving standard information (oral and written) before commencing radiation therapy, during, and after treatment. A deductive thematic analysis process was conducted.
Results
The results demonstrate how knowledge, competence, and motivation influence women’s experience of the health information process. Three main themes were found: Meeting interactive and personal needs by engaging with health information; Critical recognition of sources of information; and Capability to communicate comprehended health information. The findings reflect the women’s experience of the four competencies: to access, understand, appraise, and apply, essential elements of the health information process.
Conclusions
We can conclude that there is a need for tailored health information technology tools, such as the Digi-Do, to enable iterative access and use of reliable health information before, during and after the radiation therapy process. The Digi-Do can be seen as a valuable complement to the interpersonal communication with health care professionals, facilitating a better understanding, and enabling iterative access and use of reliable health information before, during and after the radiotherapy treatment. This enhances a sense of preparedness before treatment started.
Major excursions in sulfur isotopes linked to permafrost change in Eurasia during the last 50,000 Years.
Authors: Stevens Rhiannon , Reade Hazel , Sayle Kerry , Tripp Jennifer , Frémondeau Delphine , Lister Adrian , Barnes Ian , Germonpré Mietje , Street Martin , Murton Julian , Bottrell Simon , Higham Thomas 
Published: February 2023

Abstract
Widespread permafrost thaw is underway as arctic regions warm at twice the rate of the global average. Greenhouse gases (methane and carbon dioxide) released from thawing organic-rich permafrost soils contribute to a positive feedback loop that further accelerates global warming. There is an urgent need to understand the relationship between past permafrost conditions and palaeoclimatic change, to better predict present permafrost response to ongoing and future climate change. Through sulfur isotope analysis (δ34S) of radiocarbon-dated bone collagen samples spanning the last 50,000 years, we have identified what we term a high-magnitude Late Pleniglacial Sulfur Excursion (LPSE) in Eurasia. This anomaly is geographically widespread and several orders of magnitude higher than the sulfur isotope variation previously attributed to changing animal origin or diet alone. We show that a major change in the terrestrial sulfur cycle related to continental-scale environmental processes are, in this context, representing changing permafrost conditions. Sulfur isotope analysis of faunal samples offer an unrivalled prospect of developing high-resolution, tightly chronologically-constrained records of past permafrost change in relation to global climate changes. This would inform on the sensitivity of permafrost to past climate change, enabling constraints to be put on modelled responses of present‐day permafrost to future climate change. More broadly, our findings indicate animal δ34S values may reflect local environmental conditions, complicating the use of δ34S values as a tool for food origin, animal migration, and archaeological palaeodiet and mobility research.
Oncological Features and Prognosis of HIV-positive Colorectal Cancer: An analysis using propensity score matching
Authors: Yang Fuyu , Chen Defei , Woraikat Saed , Tang Chenglin , He Fan , Li Yao , Qian Kun 
Published: February 2023

Abstract
Background
The purpose of this study was to compare the differences in oncological features, surgical safety and prognosis between HIV positive CRC patients and HIV negative CRC patients with the same T stage and the same tumor site.
Patients and Methods
We collected a total of 24 patients with HIV infection combined with CRC who underwent radical resection of CRC. With the method of random stratified sampling, A total of 363 postoperative patients with colorectal adenocarcinoma without HIV infection were collected. After propensity score matching(PSM), we got 72 patients (HIV+∶HIV-=24∶48). The differences of perioperative serological indexes, surgical safety, oncological features and long-term prognosis were compared.
Results
Of 363 HIV negative CRC patients, 48 HIV negative patients were matched with 24 HIV positive patients. Compared with HIV negative patients, less HIV positive patients received chemotherapy, HIV+ patients had fewer preoperative leukocytes, fewer postoperative leukocytes, fewer preoperative lymphocytes, lower CEA, more intraoperative bleeding, more metastatic lymph nodes, higher N stage, higher TNM stage, shorter overall survival and shorter progression free survival.
Conclusion
Compared with HIV negative CRC patients, HIV positive patients with the same T stage and the same tumor site have more metastatic lymph nodes and worse long-term survival after surgery, but the risk of surgery will not increase.
FGFR2b is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation
Authors: Aure Marit , Symonds Jennifer , Villapudua Carlos , Dodge Joshua , Werner Sabine , Knosp Wendy , Hoffman Matthew 
Published: February 2023

Abstract
Exocrine secretory acinar cells in salivary glands (SG) are critical for oral health and loss of functional acinar cells is a major clinical challenge. Fibroblast growth factor receptors (FGFR) are essential for early development of multiple organs, including SG. However, the role of FGFR signaling in specific epithelial SG populations later in development and during acinar differentiation are unknown. Here, we predicted FGFR dependence in specific populations using scRNAseq data and conditional mouse models to delete FGFRs in vivo. We identifed essential roles for FGFRs in craniofacial and early SG development, as well as progenitor function during duct homeostasis. Importantly, we discovered that FGFR2b was critical for seromucous and serous acinar cell differentiation and secretory gene expression (Bpifa2 and Lpo) via MAPK signaling, while FGFR1b was dispensable. We show that FGF7, expressed by myoepithelial cells (MEC), activated the FGFR2b-dependent seromucous transcriptional program. We propose a model where MEC-derived FGF7 drives seromucous acinar differentiaton, providing a rationale for targeting FGFR2b signaling in regenerative therapies to restore acinar function.
Social Connectedness and Suicidal Ideation: The Roles of Perceived Burdensomeness and Thwarted Belongingness in the Distress to Suicidal Ideation Pathway
Authors: Gill Peter , Arena Michael , Rainbow Christopher , Hosking Warwick , Shearson Kim , Ivey Gavin , Sharples Jenny 
Published: February 2023

Abstract
Background:Suicide is a serious public health issue. Distress has been identified as a common risk factor, with research also suggesting that a lack of social connectedness is involved.
Methods: This quantitative, cross-sectional study investigated the role of perceived burdensomeness and thwarted belongingness in the psychological distress/suicidal ideation pathwayin a community sample of 480 Australian adults.
Results: As expected, distress was found to be a strong predictor of suicidal ideation. Perceived burdensomeness and thwarted belongingness both moderated and mediated the relationship between distress and suicidal ideation. Specifically, distress was more strongly linked to suicide ideation when burdensomeness or thwarted belongingness were also high. This moderating effect was stronger for thwarted belongingness than it was for burdensomeness. These variables also mediated the pathway, in that higher distress related to higher burdensomeness and thwarted belonging, which in turn related to higher suicide ideation. This mediating effect was stronger for burdensomeness than for thwarted belonging.
Conclusions: Overall, the findings confirm the importance of our social relatedness in suicide. Increasing belongingness and reducing the perception of being a burden on others may be an important intervention strategy for weakening the link between distress and suicide ideation.
A dual role of osteopontin in modifying B cell responses
Authors: Chunder Rittika , Schropp Verena , Marzin Manuel , Amor Sandra , Kürten Stefanie 
Published: February 2023

Abstract
Background
The occurrence of B cell aggregates within the central nervous system (CNS) has prompted investigation of the potential sources of pathogenic B cell and T cell responses in a subgroup of secondary progressive multiple sclerosis (MS) patients. Nevertheless, the expression profile of molecules associated with these aggregates and their role in aggregate development and persistence is poorly described. Here, we focused on the expression pattern of osteopontin (OPN), which is a well described cytokine, in MS brain tissue.
Methods
Autopsied brain sections from MS cases with and without B cell pathology were screened for the presence of CD20+ B cell aggregates and co-expression of OPN. To demonstrate the effect of OPN on B cells flow cytometry, ELISA and in vitro aggregation assays were conducted using peripheral blood of healthy volunteers.
Results
Although OPN was expressed in MS brain tissue independent of B cell pathology, it was also highly expressed within B cell aggregates. In vitro studies demonstrated that OPN downregulated the co-stimulatory molecules CD80 and CD86 on B cells. Furthermore, OPN-treated B cells produced significantly lower amounts of IL-6. However, OPN-treated B cells also exhibited a higher tendency to form homotypic cell aggregates in vitro.
Conclusion
Taken together, our data indicate a conflicting role of OPN in modulating B cell responses.
Hot pressed PEEK/Graphite thin film laminate composites: Thermal properties and mechanical behavior
Authors: Sariyev Bakytzhan , Abdikadyr Alina , Baitikenov Temirlan , Anuarbekov Yerbolat , Golman Boris , Spitas Christos 
Published: February 2023

Abstract
This work studies high-performance laminate composite materials made of graphite and poly(ether-ether-ketone) (PEEK). The composites were fabricated using a hot press method at a temperature below 310°C, and their structural, thermal, and mechanical properties were evaluated and discussed. SEM images of the laminate cross-section indicated a solid interfacial interaction between PEEK and graphite due to the high joining load. Thermogravimetric analysis (TGA) results showed that 3-layered PEEK/graphite/PEEK (PGP) and 5-layered PEEK/graphite/PEEK/graphite/PEEK (PG)2P composites had better thermal stability at high temperatures compared to neat PEEK. The mechanical properties tests showed that PGP had a higher Ultimate Tensile Strength (UTS) by 52% compared to neat graphite. However, adding another layer of graphite (PG)2P caused a decrease in UTS by 9.6% due to the higher volume fraction of graphite. The nanoindentation tests confirmed these findings: Young's modulus increased from 1.64 to 2.58 GPa, and the hardness increased from 0.164 to 0.178 GPa for PGP and (PG)2P, respectively. Additionally, XRD analysis indicated that the crystallinity of fabricated composites increased by 35.5% compared with pristine PEEK. The present study confirms that using PEEK and graphite sheets in composite fabrication through hot pressing improves thermal and mechanical properties.
The Multi-Omics Analyses of ACSL1 Reveal Its Translational Significance as a Tumor Microenvironmental and Prognostic Biomarker in Clear Cell Renal Cell Carcinoma
Authors: Yang Yang , Liang Jiayu , Zhao Junjie , Wang Xinyuan , Feng Dechao , Xu Hang , Shen Yu , Zhang Yaowen , Dai Jindong , Wang Zhipeng , Wei Qiang , Liu Zhenhua 
Published: February 2023

Abstract
Background: Clear cell renal cell carcinoma(ccRCC) is the dominant subtype of kidney cancer. Dysregulation of long-chain acyl-CoA synthetase 1(ACSL1) is strongly implicated in undesirable results in varieties of cancers. Nevertheless, the dysregulation and associated multi-omics characteristics of ACSL1 in ccRCC remain elusive.
Methods: We probed the mRNA and protein profiles of ACSL1 in RCC using data from the Cancer Genome Atlas, Gene Expression Omnibus, the Human Protein Atlas (HPA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC) and verified them in our patient cohort and RCC cell lines. Correlations between ACSL1 expression and clinicopathological features, epigenetic modification and immune microenvironment characteristics were analyzed to reveal the multi-omics profile associated with ACSL1.
Results: ACSL1 was down-regulated in ccRCC tissues compared to adjacent normal tissues. Lower expression of ACSL1 was linked to unfavorable pathological parameters and prognosis. The dysregulation of ACSL1 was greatly ascribed to CpG island-associated methylation modification. The ACSL1 high-expression subgroup had enriched fatty acid metabolism-related pathways and high expression of ferroptosis-related genes. In contrast, the ACSL1 low-expression subgroup exhibited higher immune and microenvironment scores, elevated expression of immune checkpoints PDCD1, CTLA4, LAG3, and TIGIT, and higher TIDE scores. Using data from the GDSC database, we corroborated that down-regulation of ACSL1 was associated with higher sensitivity towards Erlotinib, Pazopanib, and PI3K-Akt-mTOR-targeted therapeutic strategies.
Conclusion: Taken together, our findings point to ACSL1 as a biomarker for prognostic prediction of ccRCC, identifying the tumor microenvironment (TME) phenotype, and even contributing to treatment decision-making in ccRCC patients.
Reliability of speech assessments in spinocerebellar ataxia type 3/Machado-Joseph disease
Authors: Miglorini Elaine Cristina , Santos Vanessa Brzoskowski dos , Saraiva-Pereira Maria Luiza , Leotti Vanessa Bielefeldt , Olchik Maira Rozenfeld , Jardim Laura Bannach 
Published: February 2023

Abstract
Background: Spinocerebellar ataxia type 3/Machado-Joseph Disease (SCA3/MJD) is a genetic disorder characterized by ataxic manifestations. Although dysarthria is the main symptom, validated assessments of speech and voice are lacking.
Objectives: We aimed to evaluate reliability of auditory-perceptual and acoustic assessments, collected in-person and by telephone calls, and to raise data on their external validity.
Methods: Symptomatic individuals were studied. Arm 1 studied test-retest reliability of in-person speech assessments; arm 2 studied reliability of in-person and remote evaluations. Friedreich's Ataxia Rating Scale (FARS)-adl, demographic, and molecular data were also obtained. The minimum kappa for the five perceptual variables under study to be considered reliable was set at 0.8. The minimum intraclass correlation coefficients (ICC) for the 45 acoustic-instrumental assessments under study to be considered reliable was 0.70, for a p <0.05.
Results: 17 and 20 subjects were included in arms 1 and 2, respectively. All five auditory-perceptual assessments and 30 acoustic-instrumental assessments were considered reliable for the standard in-person use. Four auditory-perceptual and four acoustic assessments have also achieved reliability for use in-person and/or by telephone. Three auditory-perceptual assessments (subsystems: phonation, respiration, and resonance) and two acoustic-instrumental assessments (subsystems: respiration and articulation) correlated with age and disease duration; phonation also correlated FARS-adl.
Discussion: A substantial number of assessments of speech were considered reliable for the standard in-person use in SCA3/MJD. Moreover, eight of them were also reliable when used either in-person or remotely. Our results support their use in future studies on this disease.
Time series causal relationships discovery through feature importance and ensemble models
Authors: Castro Manuel , Júnior Pedro Ribeiro Mendes , Soriano-Vargas Aurea , Werneck Rafael De Oliveira , Gonçalves Maiara , Filho Leopoldo Lusquino , Moura Renato , Zampieri Marcelo , Linares Oscar , Ferreira Vitor , Ferreira Alexandre , Davólio Alessandra , Schiozer Denis , Rocha Anderson 
Published: February 2023

Abstract
Inferring causal relationships from observational data is a key challenge when seeking to understand the interpretability of Machine Learning models. Given the ever increasing amount of observational data available in many areas, Machine Learning algorithms used for forecasting have increased their complexity, leading to a less understandable path of how a decision is made by the model. With this in mind, we propose leveraging ensemble models, e.g., Random Forest, to assess which input features the trained model pays more attention to when making a forecast and, in this way, establish causal relationships between the variables. The advantage of those algorithms is the possibility of obtaining the feature importance, which allows us to build the causal network. We apply our methods to estimate causality in time series for two domains: One climate dataset and two oil field production datasets. We aim to perform causal discovery, i.e., establish the existing connections between the variables in each dataset. Through an iterative process of improving the forecasting of a target’s value, we evaluate whether the forecasting improves by adding information from a new potential driver; if so, we state that the driver causally affects the target. On the oil field related datasets, the results we obtained based on causal analysis agree with the interwell connections already confirmed by tracer information; for the cases when the tracer data are available, we used it as our ground truth. This agreement between both estimated and confirmed connections provides us the confidence about the effectiveness of our proposed methodology. To our knowledge this is the first time causal analysis using solely production data is employed to discover interwell connections in an oil field related dataset.
The feasibility and effectiveness of auricular acupressure on managing sleep quality, mood status, and quality of life in parents of children with cancer
Authors: Chiang Yi-Chien , Chen Shih-Hsiang , Moser Debra K. , Wen Yu-Chuan , Lin Yu-Ting 
Published: February 2023

Abstract
Purpose
To determine the feasibility and effectiveness of an auricular acupressure intervention on sleep, mood state, and quality of life (QOL) among parents of children with cancer.
Methods
In this pilot study, 35 parents were assigned to 3-weeks of an active acupressure intervention (AAG) or a sham acupressure group (SAG). Feasibility was assessed by adherence to acupressure protocol. Instruments used to test outcomes were the Pittsburgh Sleep Quality Index, Profile of Mood States, and QOL-Short-Form.
Results
Adherence to the protocol was 78%. There were no differences between the groups in overall sleep quality or mood state, but QOL in the Physical Component Summary was better in the AAG at time 1. There were differences on some QOL subscales. Parents in AAG had better Physical Functioning and General Health subscales than SAG at time 1 and time 2, respectively.
Conclusion
Likely due to small sample size, AAG and SAG did not differ in overall sleep quality, mood state, or QOL, but there were significant subscale differences that support intervention effectiveness. A fully powered large-scale trial is needed to determine if this intervention will be effective in parents. Reducing symptom distress and improving QOL in parents of children with cancer is essential. Interventions to achieve this goal must be tested.
Assessment of exercise-induced stress via automated measurement of salivary cortisol concentrations and the testosterone-to-cortisol ratio
Authors: Tsunekawa Katsuhiko , Shoho Yoshifumi , Ushiki Kazumi , Yanagawa Yoshimaro , Matsumoto Ryutaro , Shimoda Nozomi , Aoki Tomoyuki , Yoshida Akihiro , Nakajima Kiyomi , Kimura Takao , Murakami Masami 
Published: February 2023

Abstract
In this study, our aim was to validate whether the automated measurement of salivary testosterone and cortisol concentrations and the testosterone-to-cortisol (T/C) ratio considering their individual circadian rhythms can be used to assess the stress response of male athletes to different exercise intensities accurately and effectively. We measured the salivary testosterone and cortisol concentrations and their respective serum concentrations that were collected from 20 male long-distance runners via passive drooling in the morning and evening for two consecutive days involving different exercise intensities. An electrochemiluminescence immunoassay was performed to evaluate the salivary testosterone and cortisol concentrations. The results showed a positive correlation between the salivary testosterone and cortisol concentrations and their respective serum concentrations. The participants were divided into high-intensity and low-intensity exercise groups. The high-intensity exercise group showed a significantly higher rate of change in the salivary cortisol concentration and significantly lower rate of change in the T/C ratio in the evening of day 1. Our results indicated that the automated assessment of salivary cortisol concentrations and the T/C ratio could distinguish between exercises at different intensities, which may be beneficial for detecting differences in stress responses among athletes.
Effect of nitrogen content on corrosion behavior of a high nitrogen austenitic stainless steel
Authors: Qiao Yanxin , Gao Fengyin , Chen Jian , Yang lanlan , Zhou Huiling , Zheng Zhibin , Zhang Lianmin 
Published: February 2023

Abstract
A series of electrochemical tests combined with scanning electron microscopy (SEM), electron backscatter diffraction (EBSD) and X-ray photoelectron spectroscopy (XPS) were used to study the effect of nitrogen content on the composition and structure of passive film of a high nitrogen austenitic stainless steel (HNSS) in 0.5 mol/L sodium chloride solution and its corrosion performance. The results showed that the proportion of low-angle grain boundaries in the HNSS increased with the increase of nitrogen content. Electrochemical results suggested that the HNSS with a higher nitrogen content had a lower corrosion current density in 0.5 mol/L NaCl solution and thus a lower corrosion rate. This was attributable to the formation of higher proportion of stable oxides (i.e., Cr2O3) in the passive film, accelerating the passivation process and promoting the corrosion resistance.