bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous closure of an atrial septal defect in adult patients with congenitally corrected transposition of the great arteries
Authors: Khajali Zahra , Sayyadi Amin , Firouzi Atta , Aliramezany Maryam 
Published: February 2023

AbstractCongenitally corrected transposition of great arteries is a rare anomaly which are responsible for 0.5% of all CHDs and can be associated with other congenital cardiac abnormalities. Association of congenitally corrected transposition of great arteries and isolated atrial septal defect is a very rare condition, and management of this association is challenging. In this paper, we describe three patients with congenitally corrected transposition of great arteries and isolated atrial septal defect who were admitted to our clinic and all of them underwent percutaneous closure of defect. From 2017 to 2020, we visited three patients with congenitally corrected transposition of great arteries and isolated atrial septal defect. Our patients’ ages ranged from 28 to 38 years. All of them underwent percutaneous atrial septal defect device closure without any complications. Patients were discharged from hospital in good condition with a daily dose of Aspirin 80 mg and Plavix 75 mg. For all of them, follow-up echocardiography was performed the day after the procedure at 1, 3, and 6 months later and showed the function of the right-sided left ventricle improvement and the severity of the mitral regurgitation was reduced. Furthermore, clinical evaluation also indicated functional class improvement. Although the cases of percutaneous transcatheter closure are few and cannot be regarded as strong evidence to recommend this procedure, the outcomes are promising and can demonstrate that this approach is practical.
Whatever it takes to save the planet? Central banks and unconventional green policy
Authors: Ferrari Alessandro , Nispi Landi Valerio 
Published: February 2023

AbstractWe study the transmission mechanism of a Green QE, defined as a policy that tilts the central bank’s balance sheet toward green bonds, that is bonds issued by non-polluting firms. We merge a DSGE framework with an environmental model, in which CO2 emissions increase the stock of atmospheric carbon, which in turn decreases total factor productivity. Imperfect substitutability between green and brown bonds is a necessary condition for the effectiveness of Green QE. However, even under this assumption, the effect of Green QE in reducing emissions is negligible and in some cases close to nil.
Supportive Care Needs Survey: A reliability generalization meta-analysis
Authors: Lee Hyungran , Jang Yubeen , Jeong Younhee 
Published: February 2023

AbstractObjectivesThe purpose of this study is to investigate the reliability generalization of 2 forms of the Supportive Care Needs Survey (SCNS), the questionnaires commonly used to assess the unmet needs of cancer patients.MethodsReviewed articles were retrieved through databases including PubMed, Ovid, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Web of Science, Scopus, and ProQuest. The inclusion criteria were quantitative studies that assessed the unmet needs of cancer patients using the SCNS and presented reliability coefficients with sample size. Two independent reviewers examined the studies according to inclusion criteria and quality. The final studies included in the meta-analysis were determined by consensus. A random effects model was adopted for the analysis. To estimate reliability coefficients, the alpha coefficients for each study were transformed into the Z statistic for normalization and back to alpha. The values were weighted by the inverse of the studies’ variance. The Higgins I2 statistic was used to test for heterogeneity, and the Egger’s test and funnel plot were performed to evaluate publication bias.ResultsOut of 12,522 studies, 26 studies were included in the meta-analysis. The overall mean weighted effect size of the SCNS long-form (LF) was 0.90 and the subdomains ranged from 0.90 to 0.97. The overall alpha for the SCNS short-form (SF) was 0.92, and the alphas for the subdomains were between 0.81 and 0.92. The estimated reliability coefficients in both LF and SF were highest in psychological and health information needs and lowest in sexuality. No publication bias was indicated in this study.Significance of resultsIn this study, the overall reliability of SCNS was presented and the factors affecting the reliability of SCNS were identified. The results of this study may help clinicians or researchers make decisions about selecting tools to measure unmet needs of cancer patients.
Potential Vorticity Dynamics Explain How Extratropical Oceans and the Arctic Modulate Wintertime Land‐Temperature Variations
Authors: Xie Yongkun , Huang Jianping , Wu Guoxiong , Liu Yimin 
Published: February 2023

AbstractTemperature variations across the continental northern hemisphere at the interdecadal scale are thought to be remotely modulated by oceanic internal climate variability and the Arctic. Nevertheless, further elucidating the dynamics is essential for clarifying ongoing debates. We show that potential vorticity (PV) dynamics provide a concise explanation for these teleconnections. Our findings demonstrate that extratropical oceans and the Arctic can remotely modulate the wintertime continental temperature variations by stimulating PV anomalies, which are constrained by climatological PV gradients and jet streams. A causal explanation includes anomalous temperature and precipitation over oceans and the Arctic inducing local PV anomalies via diabatic heating. Subsequently, meridional and downstream advection distributes the anomalous PV to remote land regions where the climatological PV gradients are strong, that is, involving PV fronts, as well as jet streams; therefore, PV fronts and jet streams jointly indicate land regions that are largely and frequently impacted. However, land can also modulate other regions through the same mechanism when variations over land occur in advance. Clear causality depends on which factor is independent, while interactions among those regions may convolute the causality, thereby causing further debates.
Ambient Noise Tomography of the Lipari Volcanic Island (Southern Italy) From a Dense Nodal Array
Authors: Calò Marco , Di Luccio Francesca , Persaud Patricia , Ventura Guido 
Published: February 2023

AbstractWe applied ambient noise tomography to continuous data recorded by a dense seismic array deployed on the volcanic island of Lipari in the southern Tyrrhenian Sea. Since most of Lipari's seismicity occurs offshore and is not evenly distributed, this technique allowed us to obtain the first high‐resolution images beneath the island down to ∼2.5 km depth. Results show a complex seismic structure related to the various ages and compositions of the volcanic products characteristic of the different regions of the island. High shear wave velocities are found in western Lipari, where active hydrothermal vents and N‐S faults are mapped. Low wave speeds are revealed beneath southern and northeastern Lipari, where more recent volcanic activity developed along N‐S dike‐like structures that are aligned with rhyolitic vents. We suggest these dikes likely represent the probable pathways of future volcanic eruptions.
Imaging Radar Observations of the Daytime F‐Region Irregularities in Low‐Latitudes of China
Authors: He Zhiqiu , Chen Gang , Yan Chunxiao , Zhang Shaodong , Yang Guotao , Li Yaxian , Gong Wanlin , Wang Jie , Zhang Min 
Published: February 2023

AbstractHainan COherent scatter Phased Array Radar has recorded four patches of daytime F‐region field‐aligned irregularities on 31 May 2021, and it is the first time to investigate the daytime irregularities by the radar imaging technique. In‐beam radar images are plotted on the curved plane transverse to the geomagnetic field lines. The displayed daytime irregularities present the obliquely elongated band‐like structures and the corresponding scatter regions extend to hundreds of kilometers in range and narrow to a few kilometers in the zonal direction. The diffuse and isolated structures were also observed in the radar images. The radar image sequences indicate that the irregularities were continuous in height as they drifted westward. The daytime irregularities maintained the oblique elongated structures that resemble the morphological features of the nighttime equatorial plasma bubbles. Combined with the in situ satellite measurements, these daytime F‐region irregularities are interpreted to be the remnants of the previous night's bubbles and come from the higher altitudes near the magnetic equator.
Three‐Dimensional Simulation of Equatorial Spread F: Effects of Field‐Aligned Plasma Flow and Ionospheric Conductivity
Authors: Li Zezhong , Lei Jiuhou , Zhang Binzheng 
Published: February 2023

AbstractRecently a Three‐dimensional EquatoriaL spread F (TELF) model using high‐resolving power advection schemes have been developed at the University of Science and Technology of China. With the inclusion of the field‐aligned plasma flow and realistic ionospheric conductivity configuration, the TELF model reproduced typical features of the observed equatorial spread F (ESF) phenomena, including plasma depletions along flux tubes, geomagnetic conjugate irregularities, and ESF morphology as seen in ground optical and satellite observations. Through control simulations, the effects of field‐aligned plasma flow and ionospheric conductivity on ESF are investigated. It is found that field‐aligned plasma flow could inhibit the growth of bubbles by modulating the ionospheric conductivity distribution along field lines, and the plasma bubbles from the TELF model behave more physically in the topside F‐region than those from the 2D model due to the realistic ionospheric conductivity specification. Additionally, the simulations demonstrate that the amplitude and altitude of the initial perturbations can also affect the growth rate of ESF by modulating the polarization electric fields.
ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Authors: Cho Dong Im , Ahn Min Joo , Cho Hyang Hee , Cho Meeyoung , Jun Ju Hee , Kang Bo Gyeong , Lim Soo Yeon , Yoo Soo Ji , Kim Mi Ra , Kim Hyung-Seok , Lee Su-Jin , Dat Le Thanh , Lee Changho , Kim Yong Sook , Ahn Youngkeun 
Published: February 2023

AbstractAtherosclerosis, the leading cause of death, is a vascular disease of chronic inflammation. We recently showed that angiopoietin-like 4 (ANGPTL4) promotes cardiac repair by suppressing pathological inflammation. Given the fundamental contribution of inflammation to atherosclerosis, we assessed the role of ANGPTL4 in the development of atherosclerosis and determined whether ANGPTL4 regulates atherosclerotic plaque stability. We injected ANGPTL4 protein twice a week into atherosclerotic Apoe−/− mice and analyzed the atherosclerotic lesion size, inflammation, and plaque stability. In atherosclerotic mice, ANGPTL4 reduced atherosclerotic plaque size and vascular inflammation. In the atherosclerotic lesions and fibrous caps, the number of α-SMA(+), SM22α(+), and SM-MHC(+) cells was higher, while the number of CD68(+) and Mac2(+) cells was lower in the ANGPTL4 group. Most importantly, the fibrous cap was significantly thicker in the ANGPTL4 group than in the control group. Smooth muscle cells (SMCs) isolated from atherosclerotic aortas showed significantly increased expression of CD68 and Krüppel-like factor 4 (KLF4), a modulator of the vascular SMC phenotype, along with downregulation of α-SMA, and these changes were attenuated by ANGPTL4 treatment. Furthermore, ANGPTL4 reduced TNFα-induced NADPH oxidase 1 (NOX1), a major source of reactive oxygen species, resulting in the attenuation of KLF4-mediated SMC phenotypic changes. We showed that acute myocardial infarction (AMI) patients with higher levels of ANGPTL4 had fewer vascular events than AMI patients with lower levels of ANGPTL4 (p < 0.05). Our results reveal that ANGPTL4 treatment inhibits atherogenesis and suggest that targeting vascular stability and inflammation may serve as a novel therapeutic strategy to prevent and treat atherosclerosis. Even more importantly, ANGPTL4 treatment inhibited the phenotypic changes of SMCs into macrophage-like cells by downregulating NOX1 activation of KLF4, leading to the formation of more stable plaques.
A role of STING signaling in obesity-induced lung inflammation
Authors: Qi Yong , Wu Zhuhua , Chen Dan , Zhu Li , Yang Yunlei 
Published: February 2023

Abstract
Background
It is established that pulmonary disorders are comorbid with metabolic disorders such as obesity. Previous studies show that the stimulator of interferon genes (STING) signaling plays crucial roles in obesity-induced chronic inflammation via TANK-binding kinase 1 (TBK1) pathways. However, it remains unknown whether and how the STING signaling is implicated in the inflammatory processes in the lung in obesity.

Methods
Human lung tissues were obtained from obese patients (n = 3) and controls (n = 3). Mice were fed with the high-fat diet or regular control diet to establish the diet-induced obese (DIO) and lean mice, and were treated with C-176 (a specific STING inhibitor) or vehicle respectively. The lung macrophages were exposed to palmitic acid (PA) in vitro. The levels of STING singaling and metabolic inflammation factors were detected and anlyzed.

Results
We find that STING+/CD68+ macrophages are increased in lung tissues in patients with obesity. Our data also show that the expressions of STING and the levels of proinflammatory cytokines are increased both in lung tissues and bronchoalveolar lavage fluid (BALF) in obesity compared to controls, and inhibition of the STING blunted the obesity-induced lung inflammation. Mechanistically, our data demonstrate that the STING signaling pathway is involved in the PA-induced inflammation through the STING-TBK1-IRF3 (interferon regulatory factor 3)/NF-κB (nuclear factor kappa B) pathways in the lung macrophages.

Conclusions
Our results collectively suggest that the STING signaling contributes to obesity-associated inflammation by stimulating proinflammatory processes in lung macrophages, one that may serve as a therapeutic target in ameliorating obesity-related lung dysfunctions.
Rab31 promotes metastasis and cisplatin resistance in stomach adenocarcinoma through Twist1-mediated EMT
Authors: Chen Ke , Xu Ji , Tong Yu-ling , Yan Jia-Fei , Pan Yu , Wang Wei-jia , Zheng Li , Zheng Xiao-xiao , Hu Can , Hu Xiu , Shen Xian , Chen Wei 
Published: February 2023

AbstractStomach adenocarcinoma (STAD) is one of the leading causes of cancer-related death globally. Metastasis and drug resistance are two major causes of failures in current chemotherapy. Here, we found that the expression of Ras-related protein 31 (Rab31) is upregulated in human STAD tissues and high expression of Rab31 is closely associated with poor survival time. Furthermore, we revealed that Rab31 promotes cisplatin resistance and metastasis in human STAD cells. Reduced Rab31 expression induces tumor cell apoptosis and increases cisplatin sensitivity in STAD cells; Rab31 overexpression yielded the opposite result. Rab31 silencing prevented STAD cell migration, whereas the overexpression of Rab31 increased the metastatic potential. Further work showed that Rab31 mediates cisplatin resistance and metastasis via epithelial-mesenchymal transition (EMT) pathway. In addition, we found that both Rab31 overexpression and cisplatin treatment results in increased Twist1 expression. Depletion of Twist1 enhances sensitivity to cisplatin in STAD cells, which cannot be fully reversed by Rab31 overexpression. Rab31 could activate Twist1 by activating Stat3 and inhibiting Mucin 1 (MUC-1). The present study also demonstrates that Rab31 knockdown inhibited tumor growth in mice STAD models. These findings indicate that Rab31 is a novel and promising biomarker and potential therapeutic target for diagnosis, treatment and prognosis prediction in STAD patients. Our data not only identifies a novel Rab31/Stat3/MUC-1/Twist1/EMT pathway in STAD metastasis and drug resistance, but it also provides direction for the exploration of novel strategies to predict and treat STAD in the future.
Dynamic differentiation of F4/80+ tumor-associated macrophage and its role in tumor vascularization in a syngeneic mouse model of colorectal liver metastasis
Authors: Qiao Ting , Yang Wanli , He Xiangchuan , Song Ping , Chen Xiao , Liu Ruijie , Xiao Jian , Yang Xiaoli , Li Mingqi , Gao Yudan , Chen Guoan , Lu Yi , Zhang Jian , Leng Jing , Ren Huan 
Published: February 2023

AbstractTumor-associated macrophages (TAMs) are highly heterogeneous and play vital roles in tumor progression. Here we adopted a C57BL/6 mouse model imitating the late-stage colorectal liver metastasis (CRLM) by Mc38 colorectal cancer cell injection via the portal vein. With serial sections of CRLM biopsies, we defined 7–9 days post-injection as the critical period for tumor neovascularization, which was initiated from the innate liver vessels via vessel cooption and extended by vascular mimicry and thereof growth of CD34+cells. In samples with increasing-sized liver metastases, the infiltrated Ly6C+ CD11b+ F4/80− monocytes steadily gained the expression of F4/80, a Kupffer cell marker, before transformed into Ly6C− CD11bint F4/80+ cells, which, the same phenotype was also adapted by Ly6C− CD11b− F4/80+ Kupffer cells. F4/80+ TAMs showed proximity to neovascularization and tumor vessels, functionally angiogenic in vivo; and greatly promoted the activation of a few key angiogenic markers such as VEGFA, Ki67, etc. in endothelial cells in vitro. Depletion of macrophages or diversion of macrophage polarization during neovascularization impeded tumor growth and vascularization and resulted in greatly reduced F4/80+ TAMs, yet increased CD11b+ cells due to inhibition of TAM differentiation. In summary, our results showed dynamic and spatial–temporal F4/80+ TAM transformation within the tumor microenvironment and strengthened its role as perivascular and angiogenic TAMs in CRLM.
FKBP51 plays an essential role in Akt ubiquitination that requires Hsp90 and PHLPP
Authors: Tufano Martina , Marrone Laura , D’Ambrosio Chiara , Di Giacomo Valeria , Urzini Simona , Xiao Yichuan , Matuozzo Monica , Scaloni Andrea , Romano Maria Fiammetta , Romano Simona 
Published: February 2023

AbstractFKBP51 plays a relevant role in sustaining cancer cells, particularly melanoma. This cochaperone participates in several signaling pathways. FKBP51 forms a complex with Akt and PHLPP, which is reported to dephosphorylate Akt. Given the recent discovery of a spliced FKBP51 isoform, in this paper, we interrogate the canonical and spliced isoforms in regulation of Akt activation. We show that the TPR domain of FKBP51 mediates Akt ubiquitination at K63, which is an essential step for Akt activation. The spliced FKBP51, lacking such domain, cannot link K63-Ub residues to Akt. Unexpectedly, PHLPP silencing does not foster phosphorylation of Akt, and its overexpression even induces phosphorylation of Akt. PHLPP stabilizes levels of E3-ubiquitin ligase TRAF6 and supports K63-ubiquitination of Akt. The interactome profile of FKBP51 from melanoma cells highlights a relevant role for PHLPP in improving oncogenic hallmarks, particularly, cell proliferation.
Extending density functional theory with near chemical accuracy beyond pure water
Authors: Song Suhwan , Vuckovic Stefan , Kim Youngsam , Yu Hayoung , Sim Eunji , Burke Kieron 
Published: February 2023

AbstractDensity functional simulations of condensed phase water are typically inaccurate, due to the inaccuracies of approximate functionals. A recent breakthrough showed that the SCAN approximation can yield chemical accuracy for pure water in all its phases, but only when its density is corrected. This is a crucial step toward first-principles biosimulations. However, weak dispersion forces are ubiquitous and play a key role in noncovalent interactions among biomolecules, but are not included in the new approach. Moreover, naïve inclusion of dispersion in HF-SCAN ruins its high accuracy for pure water. Here we show that systematic application of the principles of density-corrected DFT yields a functional (HF-r2SCAN-DC4) which recovers and not only improves over HF-SCAN for pure water, but also captures vital noncovalent interactions in biomolecules, making it suitable for simulations of solutions.
Tailored compliant mechanisms for reconfigurable electromagnetic devices
Authors: Mackertich-Sengerdy Galestan , Campbell Sawyer D. , Werner Douglas H. 
Published: February 2023

AbstractReconfigurable electromagnetic devices, specifically reconfigurable antennas, have shown to be integral to the future of communication systems. However, mechanically robust designs that can survive real-world, harsh environment applications and high-power conditions remain rare to this day. In this paper, the general framework for a field of both discrete and continuously mechanically reconfigurable devices is established by combining compliant mechanisms with electromagnetics. To exemplify this new concept, a reconfigurable compliant mechanism antenna is demonstrated which exhibits continuously tunable performance across a broad band of frequencies. Moreover, three additional examples are also introduced that further showcase the versatility and advanced capabilities of compliant mechanism enabled electromagnetic devices. Unlike previous approaches, this is achieved with minimal part counts, additive manufacturing techniques, and high reliability, which mechanical compliant mechanism devices are known for. The results presented exemplify how compliant mechanisms have the capacity to transform the broader field of reconfigurable electromagnetic devices.
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation
Authors: Crotta Stefania , Villa Matteo , Major Jack , Finsterbusch Katja , Llorian Miriam , Carmeliet Peter , Buescher Joerg , Wack Andreas 
Published: February 2023

AbstractEpithelial tissues provide front-line barriers shielding the organism from invading pathogens and harmful substances. In the airway epithelium, the combined action of multiciliated and secretory cells sustains the mucociliary escalator required for clearance of microbes and particles from the airways. Defects in components of mucociliary clearance or barrier integrity are associated with recurring infections and chronic inflammation. The timely and balanced differentiation of basal cells into mature epithelial cell subsets is therefore tightly controlled. While different growth factors regulating progenitor cell proliferation have been described, little is known about the role of metabolism in these regenerative processes. Here we show that basal cell differentiation correlates with a shift in cellular metabolism from glycolysis to fatty acid oxidation (FAO). We demonstrate both in vitro and in vivo that pharmacological and genetic impairment of FAO blocks the development of fully differentiated airway epithelial cells, compromising the repair of airway epithelia. Mechanistically, FAO links to the hexosamine biosynthesis pathway to support protein glycosylation in airway epithelial cells. Our findings unveil the metabolic network underpinning the differentiation of airway epithelia and identify novel targets for intervention to promote lung repair.