bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making sense of renouncing: A typology of types, motives, and approaches to renouncing at work
Authors: Bardon Thibaut , Frémeaux Sandrine , Letierce Clara , Roulet Thomas 
Published: January 2023

AbstractIn this paper, we provide an exploratory account of the experience of renouncing at work—giving up a work‐related aspiration. Despite the importance of the phenomenon, the conceptualization of renouncing has been overlooked by the literature. Taking a narrative sensemaking approach to renouncing, we document variance in individual experiences to renouncing, that is, how they subjectively understand what, why, and how they renounce at work. Through a qualitative approach, we investigate the case of 30 academics working in three French business schools characterized by an increasingly influential managerialist “publish or perish” regime, a context conducive to renouncing. Based on our findings identifying various experiences of renouncing, we inductively build a matrix and a model connecting six experiences of renouncing based on the type of renouncing (renouncing in order to succeed vs. renouncing success itself) and how people approach renouncing (suffered, accepted, or chosen renouncing).
Relationship between psychosocial and psychiatric risk factors and poor long‐term outcome following mild traumatic brain injury: A systematic review
Authors: de Neeling Martijn , Liessens Dirk , Depreitere Bart 
Published: January 2023

AbstractBackground and purposeMild traumatic brain injury (mTBI) has an estimated worldwide incidence of >60 million per year, and long‐term persistent postconcussion symptoms (PPCS) are increasingly recognized as being predicted by psychosocial variables. Patients at risk for PPCS may be amenable to closer follow‐up to treat modifiable symptoms and prevent chronicity. In this regard, similarities seem to exist with psychosocial risk factors for chronicity in other health‐related conditions. However, as opposed to other conditions, no screening instruments exist for mTBI.MethodsA systematic search of the literature on psychological and psychiatric predictors of long‐term symptoms in mTBI was performed by two independent reviewers using PubMed, Embase, and Web of Science.ResultsFifty papers were included in the systematic analysis. Anxiety, depressive symptoms, and emotional distress early after injury predict PPCS burden and functional outcome up to 1 year after injury. In addition, coping styles and preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome. Associations between PPCS and personality and beliefs were reported, but either these effects were small or evidence was limited.ConclusionsEarly psychological and psychiatric factors may negatively interact with recovery potential to increase the risk of chronicity of PPCS burden after mTBI. This opens opportunities for research on screening tools and early intervention in patients at risk.
Harboring Cnm‐expressing Streptococcus mutans in the oral cavity relates to both deep and lobar cerebral microbleeds
Authors: Ikeda Shuhei , Saito Satoshi , Hosoki Satoshi , Tonomura Shuichi , Yamamoto Yumi , Ikenouchi Hajime , Ishiyama Hiroyuki , Tanaka Tomotaka , Hattori Yorito , Friedland Robert P. , Carare Roxana O. , Kuriyama Nagato , Yakushiji Yusuke , Hara Hideo , Koga Masatoshi , Toyoda Kazunori , Nomura Ryota , Takegami Misa , Nakano Kazuhiko , Ihara Masafumi 
Published: January 2023

AbstractBackgroundCerebral microbleeds (CMBs) influence long‐term prognoses of stroke patients. Streptococcus mutans expressing the collagen‐binding protein Cnm induces cerebrovascular inflammation, impairing blood brain barrier integrity and causing cerebral bleeding. Here, we examine the association of Cnm‐positive S. mutans with CMBs.MethodsAcute stroke patients were selected from a single‐center registry database. Oral carriage of Cnm‐positive or Cnm‐negative S. mutans was determined using polymerase chain reaction assays. The associations of Cnm‐positive S. mutans with CMB number and specifically the presence of >10 CMBs were examined using quasi‐Poisson and logistic regression models, respectively.ResultsThis study included 3154 stroke patients, of which 428 patients (median [interquartile range] age, 73.0 [63.0–81.0] years; 269 men [62.9%]) underwent oral bacterial examinations. In total, 326 patients harbored S. mutans. After excluding four patients without imaging data, we compared patients with Cnm‐positive (n = 72) and Cnm‐negative (n = 250) S. mutans. Harboring Cnm‐positive S. mutans was independently associated with the presence of >10 CMBs (adjusted odds ratio 2.20 [1.18–4.10]) and higher numbers of deep and lobar CMBs (adjusted risk ratio 1.61 [1.14–2.27] for deep; 5.14 [2.78–9.51] for lobar), but not infratentorial CMBs, after adjusting for age, sex, hypertension, stroke type, National Institutes of Health Stroke Scale score, and cerebral amyloid angiopathy.ConclusionsHarboring Cnm‐positive S. mutans was independently associated with a higher number of CMBs in deep and lobar locations. Reducing Cnm‐positive S. mutans in the oral cavity may serve as a novel therapeutic approach for stroke.
A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone‐based dental implant
Authors: Al‐Noaman Ahmed , Rawlinson Simon Charles Fielding 
Published: January 2023

AbstractPolyether ether ketone (PEEK) is a biocompatible material that lacks antimicrobial activity and bioactivity; therefore, is not appropriate for use as a dental implant. To overcome these deficiencies, a novel composite coating of bioactive glass and graphene oxide was prepared. PEEK discs were polished, cleaned, and the surface treated with sulfuric acid for 15 min. The composite coating consisted of bioactive glass produced by the sol‐gel route and doped with 0.75 wt% graphene oxide. X‐ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy‐energy dispersive spectroscopy analyses were employed to characterize the composite coating, and the coating adhesion strength quantified using a pull‐off test. Cytotoxicity was assessed using osteoblast‐like cells and gingival fibroblasts. The wettability of the coated and non‐coated samples was determined by optical contact angle assessment, and bioactivity was assessed by immersion in simulated body fluid. The results revealed that the bioactive glass/graphene oxide composite coating, approximately 7 μm thick, was transparent, homogenous with few microcracks and microporosities, but adhered strongly and was not cytotoxic to either osteoblast‐like cells or gingival fibroblasts. The wettability of the PEEK sample was increased to <20° after coating with the composite, and apatite formation was detectable after 14 days of immersion in simulated body fluid.
History of familial adult myoclonus epilepsy/benign adult familial myoclonic epilepsy around the world
Authors: Berkovic Samuel F. , Striano Pasquale , Tsuji Shoji 
Published: January 2023

AbstractFamilial adult myoclonus epilepsy/benign adult familial myoclonic epilepsy (FAME/BAFME) has emerged as a specific and recognizable epilepsy syndrome with autosomal dominant inheritance found around the world. Here, we trace the history of this syndrome. Initially, it was likely conflated with other familial myoclonus epilepsies, especially the progressive myoclonus epilepsies. As the progressive myoclonus epilepsies became better understood clinically and genetically, this group began to stand out and was first recognized as such in Japan. Subsequently, families were recognized around the world and there was debate as to whether they represented one or multiple disorders. Clarification came with the identification of pentanucleotide repeats in Japanese families, and FAME/BAFME was quickly shown to be due to pentanucleotide expansions in at least six genes. These have geographic predilections and appear to have been caused by historically ancient initial mutations. Within and between families, there is some variation in the phenotype, explained in large part by expansion size, but whether there are features specific to individual genes remains uncertain.
Preclinical pharmacokinetics and tolerability of a novel meglumine‐based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus
Authors: Rundfeldt Chris , Klein Pavel , Boison Detlev , Rotenberg Alexander , D'Ambrosio Raimondo , Eastman Cliff , Purnell Benton , Murugan Madhuvika , Goodkin Howard P. , Löscher Wolfgang 
Published: January 2023

AbstractObjectiveFor an antiseizure medication (ASM) to be effective in status epilepticus (SE), the drug should be administered intravenously (i.v.) to provide quick access to the brain. However, poor aqueous solubility is a major problem in the development of parenteral drug solutions. Given its multiple mechanisms of action, topiramate (TPM) is a promising candidate for the treatment of established or refractory SE, as supported by clinical studies using nasogastric tube TPM administration. However, TPM is not clinically available as a solution for i.v. administration, which hampers its use in the treatment of SE. Here, we describe a novel easy‐to‐use and easy‐to‐prepare i.v. TPM formulation using the U.S. Food and Drug Administration (FDA)–approved excipient meglumine.MethodsDuring formulation development, we compared the solubility of TPM in bi‐distilled water with vs without a range of meglumine concentrations. Furthermore, the solubility of combinations of TPM and levetiracetam and TPM, levetiracetam, and atorvastatin in aqueous meglumine concentrations was determined. Subsequently, the pharmacokinetics and tolerability of meglumine‐based solutions of TPM and TPM combinations were evaluated in rats, including animals following fluid percussion injury or pilocarpine‐induced SE.ResultsThe amino sugar meglumine markedly enhances the aqueous solubility of TPM. A comparison with data on dissolving TPM using sulfobutylether‐β‐cyclodextrin (Captisol) demonstrates that meglumine is much more effective for dissolving TPM. Furthermore, meglumine can be used to prepare drug cocktails where TPM is co‐administered with another ASM for SE treatment. The tolerability studies of the meglumine‐based TPM solution and meglumine‐based TPM combinations in normal rats and the rat fluid percussion injury and pilocarpine‐induced SE models demonstrate excellent tolerability of the novel drug solutions. Preclinical studies on antiseizure efficacy in the SE model are underway.SignificanceIn conclusion, the novel meglumine‐based solution of TPM presented here may be well suited for clinical development.
Some novel q‐rung orthopair fuzzy similarity measures and entropy measures with their applications
Authors: Ganie Abdul Haseeb , Singh Surender 
Published: January 2023

AbstractIn this paper, we have introduced some new similarity measures for ‐rung orthopair fuzzy sets and discussed their various features. These similarity measures have been constructed with the help of t‐conorms. The suggested similarity measures are more effective than the available ones in computing the similarity between distinct ‐rung orthopair fuzzy sets. With the help of these suggested similarity measures, we have also developed some novel entropy measures for ‐rung orthopair fuzzy sets. The newly proposed entropy measures are more effective than the existing ones in handling linguistic hedges. The applicability of the suggested similarity measures has been demonstrated in pattern analysis and the findings have been found to be better than due to existing ones. The traditional decision‐making method namely, the technique for order preference by similarity to the ideal solution gives us a compromise solution that is either closest to the positive ideal solution and farthest from the negative ideal solution but not both. So, to overcome this major drawback, we suggest a novel multi‐attribute decision‐making method in the ‐rung orthopair fuzzy environment and apply it to a decision‐making problem.
Flexible species distribution modelling methods perform well on spatially separated testing data
Authors: Valavi Roozbeh , Elith Jane , Lahoz‐Monfort José J. , Guillera‐Arroita Gurutzeta 
Published: January 2023

AbstractAimTo assess whether flexible species distribution models that perform well at nearby testing locations still perform strongly when evaluated on spatially separated testing data.LocationAustralian Wet Tropics (AWT), Ontario, Canada (CAN), north‐east New South Wales, Australia (NSW), New Zealand (NZ), five countries of South America (SA), and Switzerland (SWI).Time periodMost species data were collected between 1950 and 2000.Major taxa studiedBirds, mammals, plants and reptiles.MethodsWe compared 10 species distribution modelling methods with varying flexibility in terms of the allowed complexity of their fitted functions [boosted regression trees (BRT), generalized additive model (GAM), multivariate adaptive regression splines (MARS), maximum entropy (MaxEnt), support vector machine (SVM), variants of generalized linear model (GLM) and random forest (RF), and an Ensemble model]. We used established practices for model selection to avoid overfitting, including parameter tuning in learning methods. Models were trained on presence–background data for 171 species and tested on presence–absence data. Training and testing data were separated using both random and spatial partitioning, the latter based on 75‐km blocks. We calculated the average performance and mean rank of the methods (focussing on the area under the receiver operating characteristic and precision‐recall gain curves, and correlation) and assessed the statistical significance of the differences between them.ResultsThe ranking of methods did not change when evaluated on spatially separated testing data. Methods with the strongest predictive performance were nonparametric methods known to be flexible. An ensemble formed by averaging predictions of five pre‐selected modelling methods was the best model in both random and spatial partitioning, followed by MaxEnt and a variant of random forest.Main conclusionsWhilst some modellers expect methods limited to simple smooth functions to predict better spatially separated data, we found no evidence of that using blocks of 75 km. We conclude that flexible models that are tuned well enough to avoid overfitting are effective at predicting to spatially distinct areas.
Incident edentulism and number of comorbidities among middle‐aged and older Americans
Authors: Tung Ho‐Jui , Ford Randall 
Published: January 2023

BackgroundsCertain chronic non‐communicable diseases have been associated with the loss of all natural permanent teeth, referred to as edentulism. It has been suggested that edentulism, a chronic dental state, involving the loss of all teeth and poorer masticatory efficiency, could be associated with multiple chronic conditions as people age. In this study, we describe the association between the number of comorbidities and incident edentulism in a representative sample of older Americans.MethodsWe took data from the Health and Retirement Study (HRS). Dentate participants aged 50 or older at the baseline of 2006 (N = 13 221) and 2012 (N = 13 938) were linked to their dentate and survival status at the follow‐up interviews in 2012 and 2018, respectively. The association between the number of comorbidities and incident edentulism was investigated by using multinomial logistic regression models.ResultsOver the two observation periods, the number of selected chronic conditions was predictive of edentulism 6 years later. A 10% higher chance of becoming edentulous by 2012 (OR = 1.10, 95% CI = 1.01, 1.20) was found for every additional comorbid condition to those who remained dentate in 2012. A similar association was identified for the 2012–2018 period.ConclusionAmong older adults, the number of comorbidities was predictive of incident edentulism, and the same association pattern was found across two longitudinal study periods. Older adults with an increase in the number of comorbidities may experience a higher chance of tooth loss later in time.
The role of university leaders in a political crisis: Students' perspectives from Hong Kong
Authors: Lo William Yat Wai , Auld Euan 
Published: January 2023

AbstractUniversity students actively participated in the 2019 Hong Kong protests. In this context, the students expected that their universities would support their political stance. Drawing on data from interviews with student leaders, this article documents and examines students' expectations for their university heads, how they interacted and negotiated with university management and how university leaders variously responded to the students' expectations during the social movement. Noting the difficulties in reconciling conflicts over the positioning of the university amid strong political polarisation and social divisions in the society, this article argues that university leaders can only passively adapt to political unrest, and that such passive adaptation exemplifies university's vulnerability to political crises.
Stories for Change: The impact of Public Narrative on the co‐production process
Authors: Moniz Sophie , Karia Amelia , Khalid Ahmad Firas , Vindrola‐Padros Cecilia 
Published: January 2023

AbstractIntroductionInvolving service users in health service design and delivery is considered important to improve the quality of healthcare because it ensures that the delivery of healthcare is adapted to the needs of the users. Co‐production is a process used to involve service users, but multiple papers have highlighted the need for the mechanisms and values guiding co‐production to be more clearly stated. The aim of this paper was to evaluate the mechanisms and values that guided the co‐production approach of the Stories for Change project, which used Public Narrative as part of the co‐design process to create change in National Health Service maternity services.MethodsThis study was conducted using a rapid feedback evaluation approach. Semistructured interviews (n = 16) were the main source of data, six of which were maternity service users, with observations (5 h) and documentary analysis also carried out in parallel. RREAL sheets were used for data analysis to organize data based on key topics of interest.ResultsThis study identified three broad mechanisms and values underpinning the co‐production approach: creating an open and safe space to share ideas, learning how to tell stories using Public Narrative and having service providers who play a key role in strengthening the health system listen to stories compelling them to action. This study identified the main areas for improvement of the Stories for Change project related to recruitment, the inclusion of participants, the co‐design process, the Skills Session and the Learning Event.ConclusionOur study provided a deeper understanding of the co‐production approach that addresses the need to uncover the mechanism and values underlying co‐production and co‐design approaches. This study expands on the literature pertaining to the influence of storytelling in creating meaningful change in health care. We propose a co‐design methodology that uses Public Narrative as a model for service user engagement to help inform future healthcare development processes.Patient or Public ContributionThe experiences and perceptions of maternity service users and health professionals informed this evaluation. The project organizers were involved in the manuscript preparation stage by providing feedback, and service users wrote a commentary on the project from the lived experience perspective.
Self‐management and illness perception among cervical cancer patients: A cross‐sectional study
Authors: Xiong Chenxia , Jiang Chaonan , Zhang Huiling , Chen Jing , Zhao Meng , Xiong Chuyan , Luo Xia , Zhang Yue , Li Mingfang , Guo Zijun , Yan Jun 
Published: January 2023

AbstractAimThis study aimed to describe self‐management among cervical cancer patients and to elucidate the relationship between illness perception and self‐management in patients with cervical cancer.MethodsThis was a cross‐sectional study. A convenience sample of 220 cervical cancer patients was recruited from the gynaecology outpatient department of a cancer hospital. Data were collected from September 2018 to February 2019. Self‐management and illness perception were assessed using the Cancer Self‐Management Assessment Scale and the Revised Illness Perception Questionnaire for cervical cancer, respectively. Data were analysed using Pearson correlation analysis, univariate analysis and hierarchical linear regression analysis.ResultsThe mean score of self‐management was 3.87 ± 0.53, and daily life management showed the highest score (4.18 ± 0.58), while symptom management was the lowest (3.11 ± 082). Hierarchical linear regression analysis showed that family monthly income per person, types of surgery and personal control were factors that significantly influenced self‐management.ConclusionsThe results demonstrate that self‐management among patients with cervical cancer needs to be improved. The significant influence of illness perception offers an opportunity for nurses to improve self‐management behaviours of patients with cervical cancer.
Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming
Authors: Chen Lih‐Chyang , Chen Yu‐Jen , Lin Hsin‐An , Chien Wu‐Chien , Tsai Kuen‐Jou , Chung Chi‐Hsiang , Wang Jui‐Yang , Chen Chien‐Chou , Liao Nan‐Shih , Shih Chieh‐Tien , Lin Yi‐Ying , Huang Chi‐Ning , Ojcius David M. , Huang Kuo‐Yang , Lin Hsin‐Chung 
Published: January 2023

AbstractThe nucleotide‐binding and oligomerization domain, leucine‐rich repeats, and pyrin domain‐containing protein 3 (NLRP3) inflammasome plays a crucial role in innate immunity and is involved in the pathogenesis of autoinflammatory diseases. Glycolysis regulates NLRP3 inflammasome activation in macrophages. However, how lactic acid fermentation and pyruvate oxidation controlled by the mitochondrial pyruvate carrier (MPC) affect NLRP3 inflammasome activation and autoinflammatory disease remains elusive. We found that the inactivation of MPC with genetic depletion or pharmacological inhibitors, MSDC‐0160 or pioglitazone, increased NLRP3 inflammasome activation and IL‐1β secretion in macrophages. Glycolytic reprogramming induced by MPC inhibition skewed mitochondrial ATP‐associated oxygen consumption into cytosolic lactate production, which enhanced NLRP3 inflammasome activation in response to monosodium urate (MSU) crystals. As pioglitazone is an insulin sens MSDC‐itizer used for diabetes, its MPC inhibitory effect in diabetic individuals was investigated. The results showed that MPC inhibition exacerbated MSU‐induced peritonitis in diabetic mice and increased the risk of gout in patients with diabetes. Altogether, we found that glycolysis controlled by MPC regulated NLRP3 inflammasome activation and gout development. Accordingly, prescriptions for medications targeting MPC should consider the increased risk of NLRP3‐related autoinflammatory diseases.