bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature‐Inspired Solar‐Thermal Gradient Reduced Graphene Oxide Aerogel‐based Bilayer Phase Change Composites for Self‐Adaptive Personal Thermal Management
Authors: Luo Zhuo , Yang Dongzhi , Liu Ji , Zhao Hao‐Yu , Zhao Tianyu , Li Bai‐Xue , Yang Wei‐Guang , Yu Zhong‐Zhen 
Published: January 2023

AbstractAlthough personal thermal management (PTM) materials for daily routine environments are widely investigated, the exploration of multifunctional PTM materials with excellent feasibility in complex and outdoor scenarios is still in its infancy. Herein, inspired by the temperature regulation effect of the atmosphere, a novel design for fabricating solar‐thermal gradient reduced graphene oxide (RGO) aerogel‐based bilayer phase change composite (GRGC) featuring “energy regulation” and “energy inverse compensation” is proposed for self‐adaptive PTM applications. By integrating the solar‐thermal energy conversion ability of RGO, the heat regulation of the aerogel/octadecane bilayer structure with the unique gradient RGO framework inside, and the latent‐heat compensation of octadecane, the bilayer GRGC can serve as an efficient PTM device to mitigate drastic temperature changes of human skin in harsh environments. This multifunctional PTM device can not only keep a warm skin surface microclimate in a frigid environment of −5 °C via the synergistic effect of the solar‐thermal conversion, the aerogel thermal insulation, and the phase‐change latent heat release, but also provide efficient thermal buffering to prevent hyperthermia in hot environments through its phase‐change behavior and its thermal insulation. This gradient and bilayer design opens a new avenue for fabricating self‐adaptive PTM devices for applications in harsh environments.
Forage mixture productivity and silage quality from a grass/legume intercrop in a semiarid Mediterranean environment
Authors: Di Miceli Giuseppe , Licata Mario , Marceddu Roberto 
Published: January 2023

AbstractIn semiarid environments of the Mediterranean region, intercropping is a sustainable agricultural system of long standing. In this area, the pea (Pisum sativum L.) is one of the most commonly grown legume crops. Little information is available on the quality of silages to be obtained from forage mixtures of pea intercropped with cereals or annual grasses. In this study, two experiments were conducted over the course of two growing seasons in Sicily (Italy) with the aim to determine the biomass production of forage crop mixtures and assess, only in the second experiment, the silage quality of grass and legumes. Four cereals and one annual grass species were grown in pure stand and in mixture with pea, and their main agronomic traits were determined. The land equivalent ratio (LER), competitive ratio, and aggressivity index were also calculated. A number of parameters were considered to assess the quality of silage obtained from fermented biomasses derived from pea–ryegrass (Lolium multiflorum Lam. var. Westerwoldicum) intercropping. In the first experiment, the best performance between the intercrops was recorded for the pea–wheat mixture. The total LER calculated for fodder yields was always greater than 1, indicating crop yield advantages ranging from 2.0% to 47.0%. In the second experiment, the pea–ryegrass mixture appeared to respond well, depending on plant arrangement and seeding ratio factors: the ratios 50:50 and 100:50 showed the greatest crop yield advantages, of 12.0% and 11.0%, respectively. All silages revealed a very good suitability of a pea–ryegrass intercropping system with high‐quality silage production in the Southern Mediterranean region.
Changes in the prevalence of underweight, overweight, obesity and excessive adiposity among adolescents from Kraków (Poland) in the years 1983–2020
Authors: Artymiak Paulina , Żegleń Magdalena , Kowal Małgorzata , Woronkowicz Agnieszka , Kryst Łukasz 
Published: January 2023

AbstractObjectivesImproved living conditions affect lifestyles and may contribute to the increased prevalence of overweight and obesity among adolescents. The aim of the study was to analyze changes in the prevalence of underweight, overweight, obesity as well as excessive adiposity among teenagers from Kraków (Poland).MethodsThe study was conducted in four series in the years: 1983, 2000, 2010, and 2020. The study group included 1759 boys and 1699 girls aged 16–18 years. body mass index (BMI) was calculated on the basis of body height and weight. Adiposity was measured by bioimpedance method. Participants were grouped according to BMI categories using Cole's cut‐off points and according to adiposity based on mean and standard deviations values. The significance of the differences between cohorts was assessed by the Chi‐square test.ResultsSecular increase in the prevalence of underweight and overweight was observed among girls in most age groups. An increase in the prevalence of high body fat was also observed among 16‐ and 17‐year‐old girls ‐ the opposite trend was noted in 18‐year‐old girls. Contemporary boys had an increased prevalence of overweight and obesity in each age group.ConclusionThere was a significant increase in the prevalence of body weight abnormalities in the study population. The observed results may be related to socio‐economic changes that adversely affect the lifestyle of the society. The results are also important in terms of the health of future generations and may be helpful in the development of new prevention and intervention programs.
A homozygous truncating ETV4 variant in a Nigerian family with congenital anomalies of the kidney and urinary tract
Authors: Kolvenbach Caroline M. , Zheng Bixia , Merz Lea M. , Mertens Nils D. , Mansour Bshara , Wang Chunyan , Seltzsam Steve , Schneider Sophia , Schierbaum Luca , Pantel Dalia , Chen Jing , van der Ven Amelie T. , Bello Jibril O. , Shril Shirlee , Hildebrandt Friedhelm 
Published: January 2023

AbstractCongenital anomalies of the kidney and urinary tract (CAKUT) are the most prevalent cause of chronic kidney disease that manifests in children. To date ~23 different monogenic causes have been implicated in isolated forms of human CAKUT, but the vast majority remains elusive. In a previous study, we identified a homozygous missense variant in E26 transformation‐specific (ETS) Variant Transcription Factor 4 (ETV4) causing CAKUT via dysregulation of the transcriptional function of ETV4, and a resulting abrogation of GDNF/RET/ETV4 signaling pathway. This CAKUT family remains the only family with an ETV4 variant reported so far. Here, we describe one additional CAKUT family with a homozygous truncating variant in ETV4 (p.(Lys6*)) that was identified by exome sequencing. The variant was found in an individual with isolated CAKUT displaying posterior urethral valves and renal dysplasia. The newly identified stop variant conceptually truncates the ETS_PEA3_N and ETS domains that regulate DNA‐binding transcription factor activity. The variant has never been reported homozygously in the gnomAD database. To our knowledge, we here report the first CAKUT family with a truncating variant in ETV4, potentially causing the isolated CAKUT phenotype observed in the affected individual.
Childhood growth and education migration among ethnic Tibetan children from Nepal
Authors: Quinn Elizabeth A. , Sangmo Jhangchuk , Burack Sarah , Childs Geoff 
Published: January 2023

AbstractBackgroundEthnographic work among high altitude populations has shown that children are highly mobile—the most recent expression of this is the educational migration of children born at high altitude to boarding schools at lower altitudes. The impact of these patterns of migration on size for age are unknown.AimWe investigated the association between growth in weight and height and educational migration in ethnic Tibetan children living in and out of their natal communities.Subjects and methodsFive hundred and fifty eight children ages three to sixteen from the Nubri Valley, Nepal participated in this study. Three hundred children were living in natal villages and 258 were attending boarding schools in Kathmandu. Height, weight, and skinfold thicknesses were collected and matched to demographic data from the community.ResultsThere was no association between altitude of family residence and size for age z‐scores. Males had lower z‐scores than females; z‐scores for both groups declined with age. Differences in size for age among children in boarding schools were associated with two factors: sex and type of boarding school (individual sponsor or group funded). Individuals attending individually sponsored schools had greater size for age compared to children in group funded schools or in their natal villages; younger children in collectively funded schools were smaller than village peers.ConclusionsDespite popular perceptions, educational outmigration in Himalayan communities may not be associated with improved child growth outcomes and investment in community level schools may be a practical solution for improving child growth and physical and mental health.
Acute sleep loss decreases CSF‐to‐blood clearance of Alzheimer's disease biomarkers
Authors: Liu Haiyan , Barthélemy Nicolas R. , Ovod Vitaliy , Bollinger James G. , He Yingxin , Chahin Samir L. , Androff Brendan , Bateman Randall J. , Lucey Brendan P. 
Published: January 2023

AbstractIntroductionSleep deprivation increases cerebrospinal fluid (CSF) amyloid beta (Aβ) and tau levels; however, sleep's effect on Aβ and tau in plasma is unknown.MethodsIn a cross‐over design, CSF Aβ and tau concentrations were measured in five cognitively normal individuals who had blood and CSF collected every 2 hours for 36 hours during sleep‐deprived and normal sleep control conditions.ResultsAβ40, Aβ42, unphosphorylated tau threonine181 (T181), unphosphorylated tau threonine‐217 (T217), and phosphorylated T181 (pT181) concentrations increased ∼35% to 55% in CSF and decreased ∼5% to 15% in plasma during sleep deprivation. CSF/plasma ratios of all Alzheimer's disease (AD) biomarkers increased during sleep deprivation while the CSF/plasma albumin ratio, a measure of blood–CSF barrier permeability, decreased. CSF and plasma Aβ42/40, pT181/T181, and pT181/Aβ42 ratios were stable longitudinally in both groups.DiscussionThese findings show that sleep loss alters some plasma AD biomarkers by lowering brain clearance mechanisms and needs to be taken into account when interpreting individual plasma AD biomarkers but not ratios.
Revealing the Origin of Transition‐Metal Migration in Layered Sodium‐Ion Battery Cathodes: Random Na Extraction and Na‐Free Layer Formation
Authors: Chu Shiyong , Kim Duho , Choi Gwanghyeon , Zhang Chunchen , Li Haoyu , Pang Wei Kong , Fan Yameng , D'Angelo Anita M. , Guo Shaohua , Zhou Haoshen 
Published: January 2023

AbstractCation migration often occurs in layered oxide cathodes of lithium‐ion batteries due to the similar ion radius of Li and transition metals (TMs). Although Na and TM show a big difference of ion radius, TMs in layered cathodes of sodium‐ion batteries (SIBs) can still migrate to Na layer, leading to serious electrochemical degeneration. To elucidate the origin of TM migration in layered SIB cathodes, we choose NaCrO2, a typical layered cathode suffering from serious TM migration, as a model material and find that the TM migration is derived from the random desodiation and subsequent formation of Na‐free layer at high charge potential. A Ru/Ti co‐doping strategy is developed to address the issue, where the doped active Ru is first oxidized to create a selective desodiation and the doped inactive Ti can function as a pillar to avoid complete desodiation in Ru‐contained TM layers, leading to the suppression of the Na‐free layer formation and subsequent enhanced electrochemical performance.
A Polymeric Extracellular Matrix Nanoremodeler for Activatable Cancer Photo‐Immunotherapy
Authors: Zhang Chi , Xu Mengke , Zeng Ziling , Wei Xin , He Shasha , Huang Jingsheng , Pu Kanyi 
Published: January 2023

AbstractCancer immunotherapy has shown tremendous potential to train the intrinsic immune system against malignancy in the clinic. However, the extracellular matrix (ECM) in tumor microenvironment is a formidable barrier that not only restricts the penetration of therapeutic drugs but also prevents the infiltration of antitumor immune cells. We herein report a semiconducting polymer‐based ECM nanoremodeler (SPNcb) to combine photodynamic antitumor activity with cancer‐specific inhibition of collagen‐crosslinking enzymes (lysyl oxidase (LOX) family) for activatable cancer photo‐immunotherapy. SPNcb is self‐assembled from an amphiphilic semiconducting polymer conjugated with a LOX inhibitor (β‐aminopropionitrile, BAPN) via a cancer biomarker (cathepsin B, CatB)‐cleavable segment. BAPN can be exclusively activated to inhibit LOX activity in the presence of the tumor‐overexpressed CatB, thus blocking collagen crosslinking and decreasing ECM stiffness. Such an ECM nanoremodeler synergizes immunogenic phototherapy and checkpoint blockade immunotherapy to improve the tumor infiltration of cytotoxic T cells, inhibiting tumor growth and metastasis.
L‐Shaped Heterobidentate Imidazo[1,5‐a]pyridin‐3‐ylidene (N,C)‐Ligands for Oxidant‐Free AuI/AuIII Catalysis
Authors: Gao Pengcheng , Xu Jihong , Zhou Tongliang , Liu Yanhong , Bisz Elwira , Dziuk Błażej , Lalancette Roger , Szostak Roman , Zhang Dongju , Szostak Michal 
Published: January 2023

AbstractIn the last decade, major advances have been made in homogeneous gold catalysis. However, AuI/AuIII catalytic cycle remains much less explored due to the reluctance of AuI to undergo oxidative addition and the stability of the AuIII intermediate. Herein, we report activation of aryl halides at gold(I) enabled by NHC (NHC=N‐heterocyclic carbene) ligands through the development of a new class of L‐shaped heterobidentate ImPy (ImPy=imidazo[1,5‐a]pyridin‐3‐ylidene) N,C ligands that feature hemilabile character of the amino group in combination with strong σ‐donation of the carbene center in a rigid conformation, imposed by the ligand architecture. Detailed characterization and control studies reveal key ligand features for AuI/AuIII redox cycle, wherein the hemilabile nitrogen is placed at the coordinating position of a rigid framework. Given the tremendous significance of homogeneous gold catalysis, we anticipate that this ligand platform will find widespread application.
Biomolecular Click Reactions Using a Minimal pH‐Activated Catcher/Tag Pair for Producing Native‐Sized Spider‐Silk Proteins**
Authors: Fan Ruxia , Hakanpää Johanna , Elfving Karoliina , Taberman Helena , Linder Markus B. , Aranko A. Sesilja 
Published: January 2023

AbstractA type of protein/peptide pair known as Catcher/Tag pair spontaneously forms an intermolecular isopeptide bond which can be applied for biomolecular click reactions. Covalent protein conjugation using Catcher/Tag pairs has turned out to be a valuable tool in biotechnology and biomedicines, but it is essential to increase the current toolbox of orthogonal Catcher/Tag pairs to expand the range of applications further, for example, for controlled multiple‐fragment ligation. We report here the engineering of novel Catcher/Tag pairs for protein ligation, aided by a crystal structure of a minimal CnaB domain from Lactobacillus plantarum. We show that a newly engineered pair, called SilkCatcher/Tag enables efficient pH‐inducible protein ligation in addition to being compatible with the widely used SpyCatcher/Tag pair. Finally, we demonstrate the use of the SilkCatcher/Tag pair in the production of native‐sized highly repetitive spider‐silk‐like proteins with >90 % purity, which is not possible by traditional recombinant production methods.
Dynamic Lone Pair Expression as Chemical Bonding Origin of Giant Phonon Anharmonicity in Thermoelectric InTe
Authors: Zhang Jiawei , Ishikawa Daisuke , Koza Michael M. , Nishibori Eiji , Song Lirong , Baron Alfred Q. R. , Iversen Bo B. 
Published: January 2023

AbstractLoosely bonded (“rattling”) atoms withs2lone pair electrons are usually associated with strong anharmonicity and unexpectedly low thermal conductivity, yet their detailed correlation remains largely unknown. Here we resolve this correlation in thermoelectric InTe by combining chemical bonding analysis, inelastic X‐ray and neutron scattering, and first principles phonon calculations. We successfully probe soft low‐lying transverse phonons dominated by large In1+z‐axis motions, and their giant anharmonicity. We show that the highly anharmonic phonons arise from the dynamic lone pair expression with unstable occupied antibonding states induced by the covalency between delocalized In1+5s2lone pair electrons and Te 5pstates. This work pinpoints the microscopic origin of strong anharmonicity driven by rattling atoms with stereochemical lone pair activity, important for designing efficient materials for thermoelectric energy conversion.
Outburst behavior of the dwarf nova CG Draconis
Authors: Usatov Maxim , Shears Jeremy 
Published: January 2023

AbstractDuring the British Astronomical Association (BAA) 2022 campaign, 27,436 photometric observations of the dwarf nova (DN) CG Draconis were made, with 106 eclipses recorded. This work summarizes the new data available and provides updated ephemeris and commentary on the observed eclipse profiles. The orbital period found is . Two types of quasi‐periodic outbursts are identified: normal outbursts, of mag amplitude, and bright, of mag. The pattern resembles superoutbursts of SU UMa‐type DNe, however, no presence of superhumps characterizing these DNe was found. Given CG Dra is located above the period gap, it may represent a new intermediary subtype between SS Cyg and SU UMa‐type stars, or provide support to superoutburst models that do not rely on eccentric accretion disks.
A rational design of AIE‐active fluorophore for the fingerprint optical detection
Authors: Yu Le , Xu Yunjie , Kim Jungryun , Lee Jieun , Kim Jong Seung 
Published: January 2023

AbstractFingerprints are one of the distinguishing characteristics of an individual, remaining unaltered throughout one's lifetime. It should be noted that fingerprints are significant and reliable evidence in various cases, such as criminal investigations, medical diagnosis, and public security. Thus, it is necessary to develop efficient techniques for fingerprints detection. Fortunately, the fluorescence emission of aggregation‐induced emission (AIE) materials would increase instead of quenching upon excitation when they label fingerprints, which would clearly observe the structure of fingerprints. Herein, we devised a novel AIE‐active fluorophore (NI‐DB) with electron donor‐π bridge‐electron acceptor (D‐π‐A) structure based on the 1,8‐naphthalimide. To our delight, after fingerprints fixed by cyanoacrylate glue fuming, NI‐DB is capable of detecting and imaging fingerprints via its intrinsic fluorescence emission. And, with the aid of this technique, fingerprints on various object surfaces are successfully developed, suggesting the broad applicability.
Inhibition of α‐Glycosidase by Lippia dulcis Trevir. (Verbenaceae) Preparations, Quantification of Verbascoside, and Study of Its Molecular Docking
Authors: Ritter Ruas Natalia , Carvalho Pereira Aline , Lopes Silva Pereira Luciana , Mesquita Germano Carolina , Fontes Ferreira da Cunha Elaine , Alves de Carvalho Alexandre , Alves Lameira Osmar , Eduardo Brasil Pereira Pinto José , Kelly Vilela Bertolucci Suzan 
Published: January 2023

AbstractThis study aimed to quantify verbascoside (VEB), perform molecular docking studies of VEB with the α‐glucosidase (GL) of Bacillus stearothermophilus, and evaluate the inhibition of the enzyme by L. dulcis preparations. The substrate concentration and presence of reduced glutathione were evaluated for their effect on the in vitro inhibition of the GL enzyme. Assays were also performed in the presence and absence of simulated gastric fluid. The antidiabetic fractions 2 and 3 were the most inhibited GL, but their activity were significantly decreased in the presence of gastric fluid. Chromatographic analyses confirmed the predominant presence of VEB in the samples. The samples had VEB concentrations between 49.9 and 243.5 mg/g. Simulation of the molecular docking of VEB were consistent with its GL‐inhibitory activity. It can conclude that the crude ethanol extract and fractions show inhibitory activity against the GL enzyme.
Highly Efficient Light‐Driven CO2 to CO Reduction by an Appropriately Decorated Iron Porphyrin Molecular Catalyst
Authors: Stoumpidi Aspasia , Trapali Adelais , Poisson Marie , Barrozo Alexandre , Bertaina Sylvain , Orio Maylis , Charalambidis Georgios , Coutsolelos Athanassios G. 
Published: January 2023

AbstractThe photocatalytic CO2 reduction into value‐added chemicals is regarded as one promising technology to mitigate environmental issues and the energy crisis of the modern world due to the extended CO2 emissions. Recent advances have shown that iron porphyrins are considered as one of the most efficient molecular catalysts in the activation and reduction of molecules like CO2. Thus, a suitably modified FeIII porphyrin ([FeIII(TF4TMAP)](CF3SO3)5) was prepared and its catalytic activity in terms of photocatalytic reduction of CO2 was studied. This iron catalyst possesses four fluorine substituents in the ortho and the meta position of each meso‐phenyl group of the porphyrin, while trimethylammonium groups were placed in the para position. Photocatalytic studies were performed in the presence of an iridium complex as a chromophore and have shown that [FeIII(TF4TMAP)](CF3SO3)5 can effectively reduce CO2, achieving excellent turnover numbers (up to 5500 TONs) and high turnover frequencies. The main reduction product of this photocatalytic system was CO, and only a small amount of hydrogen was detected, presenting a maximum selectivity of 86 % for CO.
Role of Copper Migration in Nanoscale Ageing of Supported CuO/Al2O3 in Redox Conditions: A Combined Multiscale X‐ray and Electron Microscopy Study
Authors: Sharna Sharmin , Rouchon Virgile , Legens Christèle , Taleb Anne‐Lise , Stanescu Stefan , Bouillet Corinne , Lambert Arnold , Briois Valerie , Chiche David , Gay Anne‐Sophie , Ersen Ovidiu 
Published: January 2023

AbstractChemical Looping Combustion is a promising midterm solution to mitigate CO2 emission, by carrying out indirect fuel combustion and allowing inherent separation of CO2. During the CLC process, an oxygen carrying material is subjected to successive oxidation‐reduction reactions at high temperature which induce significant material degradation. CuO/Al2O3 based materials have been widely considered as promising oxygen carriers (OC). However, the oxygen carrier ageing mechanisms (active phase migration and interactions with the support, phase transitions) are not well understood. Herein, an in‐depth overview of the material evolution is achieved by employing a multi‐scale characterization approach. At the μm‐scale, copper migration within the alumina support has been observed using Scanning Transmission X‐ray Microscopy (STXM) and Scanning Electron Microscopy (SEM). The spatial distribution of the Cu−Al species provides information on copper mobility and the different phases interactions. A comprehensive mechanism is proposed concerning the redox behaviour of the CuO/Al2O3 system, relating the diffusion of the Cu‐species, the active phase‐support interactions, and the role of copper in the Al2O3 support phase transition to the temperature and the number of redox cycles. Understanding the ageing process of CuO/Al2O3 materials paves a way to design more stable oxygen‐carriers.