bluuebunny/crossref_metadata_2025_split huggingface dataset:
TIPS-10 FEASIBILITY OF A MULTI-MODALITY CENTRAL NERVOUS SYSTEM SCREENING EVALUATION IN HER2+ BREASTCANCER PATIENTS
Authors: Malani Rachna , Seidman Andrew , Dang Chau , Panageas Katherine , Young Robert , Boire Adrienne , Wilcox Jessica 
Published: August 2023

Abstract

BACKGROUND
Breast cancer is the most common cancer in the world and the second most common to metastasize to the central nervous system (CNS). CNS-metastases are the most common type of brain tumor and have a rising incidence. They are associated with neurologic morbidity and mortality and remain a major clinical challenge. Survival withCNS-metastases is short with a median survival in the order of months. The incidence of CNS-metastases is 5.1% in breast cancer however true prevalence is not known; at autopsy this incidence ranges between 20-40%. One contributing factor towards the development of CNS-metastases in breast cancer is HER2-positivity. Between 25%-48% of patients with HER2-positive metastatic breast cancer develop CNS-metastases. Currently, routine CNS surveillance imaging is not recommended, however guidelines suggest having a low threshold for evaluation with imaging and/or cerebrospinal fluid (CSF) analysis because of the high rate of CNS-metastases. The clinical relevance of occult CNS-metastases, survival after identification of occult CNS-metastases and the importance of earlier initiation of CNS therapy are unknown. Existing treatment strategies for CNS-metastases rely on a combinatorial approach of chemotherapy, radiotherapy and/or surgery which typically affords limited disease control. This trial seeks to study if surveillance imaging and CSF analysis are feasible as early disease detection mechanisms.

METHODS
This is a two-cohort study to establish feasibility of multi-modality CNS surveillance. Patients with HER2+ metastatic breast cancer patients (with no known CNS-metastases) who are either Stage IV (Cohort A) or Stage II/III are eligible (Cohort B). On study, patients will undergo MRI Brain and CSF analysis at 6 monthly intervals. CSF analysis includes cytology, circulating tumor cells and cell-free DNA analysis. We plan to enroll 20 patients (10 onto each cohort). 1 of 20 patients have enrolled. This is the first multi-modality screening feasibility study for patients HER2-positive breast cancer.
TIPS-13 A PHASE II STUDY OF NEOADJUVANT CAMRELIZUMAB AND APATINIB IN PATIENTS WITH RECURRENT HIGH-GRADE GLIOMAS
Authors: Guo Chengcheng , Yang Qunying , Cao Xi , Liao Yixiang , Zhang Ji , Jiang Xiangbing , Li Deipei , Chen Yinsheng , Chen Zhongping 
Published: August 2023

Abstract

BACKGROUND
A single arm clinical trial (NCT04588987) about combination therapy of programmed cell death protein 1 blockades camrelizumab with antiangiogenic agent apatinib has been initiated to investigate their effectiveness for patients with recurrent high-grade Gliomas (HGG).

METHODS
Patients with recurrent HGG will receive single-dose intravenous injection of camrelizumab (200 mg) and daily oral administration of apatinib (250 mg/day for 7 days) 14 days before surgery for recurrent tumor. Sequential therapy will begin 2 weeks after surgery with the biweekly injection of camrelizumab and 4 weeks after surgery with the daily administration of apatinib.

RESULTS
Up to date (March 9, 2023), 18 patients are enrolled (13 for recurrent glioblastomas and 5 for anaplastic astrocytoma), with a medial follow-up time is 19 months. The median cycles of postoperative combination therapies were 4.5 cycles (95%CI: 3.87-5.12 ), with median progression-free survival of 4.0 months (95%CI: 2.78-5.28 ). One patient (1/18, 5.5%) discontinue the combination treatment because the patient often underwent the extended periods of hospitalization because of unacceptable liver dysfunction, and the other patient (1/18, 5.5%) withdraw the from the trail after receiving the surgery. All enrolled patients appeared one or more treatment-related adverse effects. The most common adverse effects were constipation(58%), hypertension (52%), leukocytopenia (52%), and nausea (47%).

CONCLUSION
the short-term results indicated that the combination therapy might be beneficial for patients with recurrent HGG and improve the patients’ overall survivals. We will present our detailed progress and results on the conference.
TIPS-20 A RANDOMIZED, CONTROLLED TRIAL OF BERUBICIN, A TOPOISOMERASE II POISON THAT APPEARS TO CROSS THE BLOOD-BRAIN BARRIER (BBB), AFTER FIRST-LINE THERAPY FOR GLIOBLASTOMA MULTIFORME (GBM): PRELIMINARY RESULTS
Authors: Silberman Sandra , Hsu Sigmund , Muzyczenko Zena , Picker Donald 
Published: August 2023

Abstract
Berubicin is a doxorubicin (Dox) analog that appears to cross the BBB with significant central nervous system (CNS) uptake. Berubicin prolongs survival in orthotopic mouse intracranial models with greater infiltration of the tumor compared to normal tissue. A Phase 1 dose-escalation study showed myelosuppression as the dose-limiting toxicity, with 1 complete response (14+ years), 1 partial response durable for 12 weeks, and 9 patients with stable disease for a clinical benefit rate of 44%. A trial of Berubicin vs Lomustine in patients with recurrent GBM after first-line therapy in the US and Europe is enrolling patients in a 2:1 randomization design of Berubicin:Lomustine. Patients will be stratified by MGMT methylation status. The primary endpoint is overall survival (OS). A pre-planned, non-binding futility analysis will be performed after approximately 30 to 50% of all planned patients have reached the primary endpoint. Currently, 97 patients are enrolled with 65 in the Berubicin arm and 32 in the Lomustine arm. At present these patients show comparable demographics, with an unmethylated MGMT population of ~60% in both arms. Patients with all grades of adverse events were 80% and 69% on the Berubicin and Lomustine arms, respectively. Grade 3-4 events were 43% (Berubicin arm) and 38% (Lomustine arm), although less than or equal to 5% of patients discontinued the study due to these events. The data available shows that Berubicin and Lomustine arms are presently balanced with relatively comparable safety profiles. The study is continuing to evaluate the efficacy of this novel drug candidate and potentially provide therapeutic options for patients after first-line therapy. An updated profile of the patient population, safety, and initial efficacy will be presented.
Association between fresh fruit consumption and the risk of chronic obstructive pulmonary disease-related hospitalization and death in Chinese adults: a prospective cohort study
Authors: Huang Xin , Li Jiachen , Cao Weihua , Lyu Jun , Guo Yu , Pei Pei , Xia Qingmei , Du Huaidong , Chen Yiping , Ling Yang , Kerosi Rene , Stevens Rebecca , Yang Xujun , Chen Junshi , Yu Canqing , Chen Zhengming , Li Liming 
Published: August 2023

Abstract

Background:
Existing evidence suggests that fruit consumption is a significant influencing factor for chronic obstructive pulmonary disease (COPD), but this is unclear in the Chinese population. We examined the association of fresh fruit consumption with the risk of COPD-related hospitalization and death in a nationwide, population-based prospective cohort from China.

Methods:
Between 2004 and 2008, the China Kadoorie Biobank recruited >0.5 million adults aged 30 to 79 years from ten diverse regions across China. After excluding individuals diagnosed with major chronic diseases and prevalent COPD, the prospective analysis included 421,428 participants. Cox regression was used to calculate the hazard ratios (HRs) for the association between fresh fruit consumption and risk of COPD-related hospitalization and death, with adjustment for established and potential confounders.

Results:
During a mean follow-up of 10.9 years, 11,292 COPD hospitalization events and deaths were documented, with an overall incidence rate of 2.47/1000 person-years. Participants who consumed fresh fruit daily had a 22% lower risk of COPD-related hospitalization and death compared with non-consumers (HR = 0.78, 95% confidence interval [CI]: 0.71–0.87). The inverse association between fresh fruit consumption and COPD-related hospitalization and death was stronger among non-current smokers and participants with normal body mass index (BMI) (18.5 kg/m2 ≤ BMI < 24.0 kg/m2); the corresponding HRs for daily fresh fruit consumption were 0.78 (95% CI: 0.68–0.89) and 0.69 (95% CI: 0.59–0.79) compared with their counterparts, respectively.

Conclusions:
High-frequency fruit consumption was associated with a lower risk of COPD in Chinese adults. Increasing fruit consumption, together with cigarette cessation and weight control, should be considered in the prevention and management of COPD.
Socialization, education and learning for the internet (SELFI): development and pilot of a social media skills program for autistic adults
Authors: Osuna Anthony , Tagavi Daina , Sabini Katie , Vernon Ty 
Published: August 2023

Purpose
The purpose of this paper is to describe the development and pilot of a novel program to support autistic adults with social media use. Social media use among autistic adults has been associated with increased happiness and closer friendships. However, autistic adults are at risk of social media challenges such as cyber-victimization. To date, no programs exist that specifically support autistic adults with safe and effective social media use. The primary aim of this study was to develop and pilot test a novel social media skills program for feasibility and acceptability. A secondary aim was to explore changes in Facebook activity as a proxy for online social engagement.

Design/methodology/approach
The socialization, education and learning for the internet (SELFI) program was developed by identifying relevant target skills, goals, considerations and evidence-based strategies to help autistic adults with online social communication. The developed SELFI program was then pilot tested with six autistic male young adults to explore initial feasibility (fidelity of delivery, attendance) and acceptability (attrition, enjoyment and programmatic feedback). Facebook data were collected to explore differences in the frequency of likes/reactions, comments and posts after completion of the program.

Findings
Each participant completed all procedures and attended every session. There was no attrition from the program. The average fidelity score for recorded sessions was 85.1%. Most participants endorsed agreement with program enjoyment and that it helped them maintain current relationships. Participant feedback provided valuable information regarding areas of strength and areas that needed improvement. Each participant who completed the study demonstrated increased Facebook engagement across likes/reactions, comments and posts.

Research limitations/implications
Limitations include a small all-male sample, exclusion of adults with intellectual disabilities and adolescents and dependence on Facebook data. Additionally, the developed program did not incorporate feedback from relevant stakeholders, including autistic adults.

Originality/value
To the best of the authors’ knowledge, this is one of the first studies to explore support for autistic adults specifically related to social media use.
Influence of social media influencer authenticity on their followers' perceptions of credibility and their positive word-of-mouth
Authors: Wang Edward Shih-Tse , Weng Yu-Jou 
Published: August 2023

PurposeIncreasing followers' positive word-of-mouth (PWOM) is a critical means through which social media influencers (SMIs) marketers can increase SMIs' follower count. Studies have reported that authenticity and credibility increase followers' PWOM and have identified the dimensions of authenticity (i.e. originality, naturalness and continuity) and credibility (i.e. attractiveness, trustworthiness and expertise). However, the mechanisms underlying the associations among these dimensions are unclear. Drawing from social exchange theory, the authors developed an integrated conceptual model and explored how the dimensions of SMI authenticity affect those of followers' perception of credibility. Moreover, the authors analyzed how followers' perception of credibility affects the followers' PWOM behavior.Design/methodology/approachThe authors collected 463 valid questionnaires from respondents that followed at least one SMI. Additionally, the authors developed a structural equation model for data analysis.FindingsThe results revealed that the subdimensions of SMI authenticity have different effects on followers' perception of credibility. An SMI's continuity positively affects followers' perceptions of the SMI's trustworthiness and expertise. The naturalness of an SMI positively affects followers' perception of the SMI's attractiveness but nonsignificantly affects followers' perception of the SMI's trustworthiness. Additionally, an SMI's originality positively affects followers' perception of the SMI's attractiveness but negatively affects followers' perception of the SMI's trustworthiness. Finally, followers' perceptions of an SMI's attractiveness, trustworthiness and expertise all positively affect followers' PWOM behavior.Originality/valueBy employing multidimensional constructs, the authors obtained results that provide a comprehensive understanding of the effects of SMI authenticity on the SMI's followers' perception of followers' credibility. These results can be used by SMIs to increase SMIs followers' PWOM by determining which aspects of authenticity and credibility SMIs should develop.
A scale for measuring tourists’ technological competence
Authors: Lin Wei-Rong , Lee Shin-Shiuan , Huang Wen-Shiung 
Published: August 2023

Purpose
Tourists must possess technological competence, as technology becomes increasingly ubiquitous in travel. However, few studies have investigated tourists’ technological competence (TTC). Thus, this study aims to develop a valid and reliable scale for measuring TTC.

Design/methodology/approach
In the development of the scale, the authors first reviewed the literature and consulted experts to formulate an initial set of items. The items were then reduced using exploratory factor analysis, and the measures were validated through confirmatory factor analysis. Two distinct sets of data were collected to develop and validate the TTC scale.

Findings
The final scale has 21 items and five factors: searching and booking for travel information online, using self-service systems, operating VR/AR technologies, using apps for travel and using technology at tourist destination. After analyzing the reliability, construct validity, criterion-related validity and known-group validity, the TTC scale has been established as a measurement tool with acceptable reliability and validity.

Originality/value
The authors proposed the concept of technological competence in tourists and developed a scale to measure it. In addition to filling research gaps, understanding the items relating to TTC can help promote tourism education in the digital and technological age and provide reference for those developing technological services at tourist destinations.
Intellectual capital's contribution to innovative female agri-start-ups: a multiple case study
Authors: Modaffari Giuseppe , Paoloni Niccolò , Manzo Martina 
Published: August 2023

PurposeWomen-led enterprises can count on intellectual capital (IC) to implement a knowledge exchange process, improve managerial skills and provide themselves with more certain and reasonable financial resources. Recently, the literature has recognized a new paradigm of innovation, known as open innovation (OI) that emphasizes the strategic importance of relationships for knowledge development. The paper, first, aims to investigate if IC can support female agri-start-ups’ innovation process. Second, the aim is to analyse the ways in which IC supports female agri-start-ups.Design/methodology/approachThe work uses a qualitative methodology and a multiple case study supports the paper. Data were acquired using direct semi-structured interviews. To read and interpret them, the authors resorted to the C.A.O.S. model that permits examining the direct relationships in terms of relational capital (RC) and also, observing the effect produced by the relational circuit in terms of human capital (HC) and structural capital (SC) in small and medium enterprises.FindingsFindings reveal that RC plays a fundamental role in innovative start-up's development. The S-C and S-O links support business management and help fill the gender financial gap. This leads to improving entrepreneurial skills (HC) and promoting internal innovative solutions (SC). The S-A links can help the entrepreneur acquire more awareness of the market and compete better.Originality/valueThe research contributes to IC and gender studies, with a specific focus on RC and the innovation process. Although the literature has already investigated the role of RC in female entrepreneurship, only few previous research have conducted a qualitative analysis about the relationships established in the peculiar context of innovative agri-start-ups.
Australian public libraries during the COVID-19 crisis: operations, management and service provision
Authors: Wakeling Simon , Garner Jane , Kennan Mary Anne , Hider Philip , Jamali Hamid R. , Randell-Moon Holly Eva Katherine , Mansourian Yazdan 
Published: August 2023

PurposeThe purpose of this research was to investigate how Australian public libraries responded to the COVID-19 pandemic in terms of management, planning and communication. The study also investigated operational approaches to the development and implementation of new and adapted models of service and resource delivery.Design/methodology/approachUtilising a multiple qualitative case study approach, interviews were conducted with 15 Australian public library staff members at three library services – one inner-city, one regional and one remote. Inductive thematic analysis was employed to generate insights into the operations and management strategies employed during the COVID-19 crisis.FindingsFindings suggest that public library managers performed admirably in the face of significant logistical, budgetary and regulatory challenges. Five key themes emerged to represent the ways in which public library leaders responded effectively to the crisis: resourcefulness, flexibility, presence, sensitivity and communication. Results also demonstrate the importance placed on library users’ welfare.Originality/valueThis research represents the first study to focus on the response of Australian public library managers to the significant challenges posed by the COVID-19 pandemic, and to identify the strategies employed by library leaders to respond effectively. In doing so this research provides valuable insights into how public library managers can prepare for future crises.
The joint effects of partner rotation and allocation of audit hours on audit quality
Authors: Kang Minjung , Kim Sangil , Lee Ho-Young 
Published: August 2023

Purpose
This study aims to examine the effects of allocation of audit hours to year-round audits and audit partners on audit quality when a new partner is appointed.

Design/methodology/approach
Using proprietary data of partners’ names and audit hours in the year-round context, the authors build a model testing input factors related to audit production and new partner assignment in 1,209 Korean listed firms during the period of 2015–2018.

Findings
The results show that in the partner rotation, the more audit hours spent, the more audit hours are allocated to the year-round audit, or more nonpartners’ audit hours are allocated to the year-round audit, the higher the audit quality. Subsample analyses show that these findings are concentrated in firms with longer audit tenure or low audit risk.

Research limitations/implications
The findings may provide regulatory authorities with practical guidelines concerning partner rotation and how to allocate audit hours to different audit stages and ranks (partner vs staff).

Originality/value
To the best of the authors’ knowledge, this study provides the first evidence of the joint effects of partner rotation and audit hour allocation on audit quality.
Assessing the relationship between officers' broad cultural attitudes and their situational perceptions of firearm danger
Authors: Somers Logan J. , Terrill William 
Published: August 2023

PurposeThe focus of the current study is to assess whether officers' broad attitudinal orientations are linked with their situational perceptions of danger in various armed citizen encounters.Design/methodology/approachThe authors draw on survey data from 672 officers employed at a large metropolitan police department. The police culture literature is used to inform measures of occupational stress, danger, citizen distrust, views of upper management, and role orientation in relation to how officers perceive danger across a series of scenarios involving armed citizens that varied in terms of firearm placement and citizen resistance. Along with a host of control variables, a series of multivariate models are used to evaluate the degree to which these aggregated cultural views may shape officers' situational perceptions of danger.FindingsThe results indicate that a stronger endorsement of broad attitudinal orientations involving occupational danger and citizen distrust are linked with higher perceptions of danger in armed-citizen encounters, especially as the situations become more discretionary.Originality/valueEmpirical research related to police culture has typically relied upon highly aggregated assessments of how officers view their occupational and organizational work environments. However, yet to be explored is whether these broad views impact officers' assessments of specific encounters, particularly those that are dangerous in nature. The findings from this study also have the potential to inform ambiguous use of force standards that are heavily influenced by officers' situational assessments of danger.