bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of Moringa Leaf Compounds as Colon Anticancer Agents Using Bioinformatics and Molecular Docking Methods
Authors: Saputri Dwi , Kusumaningtyas Triana , Setiadi Prismo , Febriansah Rifki 
Published: June 2023

Introduction - Colon cancer is a disease that has a high mortality rate. Cancer treatments such as chemotherapy can cause severe side effects. So, it is necessary to do research on herbal plants to minimize these side effects. The bioactive compounds in Moringa leaves (Moringa oleifera L.) are known to have antioxidant and anticancer activity, so they have the potential to be used as cancer treatment. Purpose – . This study aims to determine the potential of Moringa leaves as an anticancer agent in silico.
Methodology/Approach – The in silico test used is STITCH-STRING bioinformatics and molecular docking. STITCH-STRING bioinformatics was used to determine the target protein of the test compound, and molecular docking was used to determine the binding affinity between the test compound and cancer protein. Findings – In the STITCH-STRING bioinformatics test, the potential targets for kaempferol and quercetin were TP53-ESR1 and STAT3-EGFR, respectively.test Molecular docking on cancer protein showed that quercetin compound in EGFR protein had the best binding with a docking score of -9.2 kcal/mol. This shows good results because the docking score obtained is lower than the comparison drug (Fluorouracil) which has a docking score of -4.2 kcal/mol. These results indicate that compounds in Moringa leaves (Moringa oleifera L.) have the potential to be used as anticancer agents. Originality/ Value/ Implication – Moringa leaf research using bioinformatics and molecular docking methods is still rarely done, so this research can be used as further knowledge related to the search for moringa leaf compounds that have the potential for anticancer using bioinformatics and molecular docking methods
Sistemas Ciberfísicos desenvolvidos para apoio na manutenção centrada em confiabilidade: uma aplicação em subestações de energia e central de compressores
Authors: Ribeiro Brando Samuel , Cecconello Ivandro 
Published: June 2023

A Industria 4.0 e as tecnologias relacionadas a Internet of Things (IoT) têm avançado dentro das organizações e em ambientes industriais diversificados, trazendo consigo inovações disruptivas e transformações na gestão industrial destes cenários. O setor de manutenção tem papel importante como habilitador e desenvolvedor de recursos, dispositivos e ferramentas digitais tanto para processos de manufatura quanto para os seus processos internos relacionados a disponibilidade, confiabilidade, capabilidade e manutenibilidade dos ativos geridos. A partir disso, o presente artigo é baseado em um estudo de caso de observação e experimentação, demonstrando os processos, a implementação e os resultados obtidos no desenvolvimento de ferramentas digitais, dispositivos de monitoramento em tempo real e supervisórios para o gerenciamento remoto dos ativos críticos (subestações elétricas e compressores) de uma empresa do segmento metalmecânico da serra gaúcha. Os resultados demonstraram as seguintes vantagens: menor tempo para tomada de decisão por parte da gestão, os custos de manutenção são reduzidos, o risco de paradas nas operações é minimizado, além da otimização da manutenibilidade e economia de energia.

Cyberphysical Systems developed to support reliability-centric maintenance: an application in power substations and compressor centers
Abstract: Industry 4.0 and Internet of Things (IoT) related technologies have advanced within organizations and in diverse industrial environments, bringing with them disruptive innovations and transformations in the industrial management of these scenarios. The maintenance sector plays an important role as an enabler and developer of resources, devices and digital tools both for manufacturing processes and for its internal processes related to the availability, reliability, capability and maintainability of managed assets. From this, the present article is based on a case study of observation and experimentation, demonstrating the processes, the implementation and the results obtained in the development of digital tools, devices for monitoring in real time and supervisory for the remote management of critical assets (electrical substations and compressors) of a company in the metalworking sector in the mountain region . The results showed the following advantages: less time for management to make a decision, maintenance costs are reduced, the risk of stoppages in operations is minimized, in addition to optimizing maintainability and energy savings.
Exosomes from Adipose Tissue-derived Mesenchymal Stem Cells Induce Regulatory T Cells in COVID‐19 Patients
Authors: Motallebnezhad Morteza , Hazrati Ali , Gouvarchin Ghaleh Hadi Esmaeili , Jonaidi-Jafari Nematollah , Abbaspour-Aghdam Sanaz , Malekpour Kosar , Yousefi Mehdi , Kafil Hossein Samadi , Jadidi-Niaragh Farhad , Roshangar Leila , Valizadeh Hamed , Izadi Morteza , Ahmadi Majid 
Published: June 2023

An imbalance between regulatory T (Treg) and T-helper (Th)-17 cells has been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) exert immunomodulatory properties through secreting exosomes. This study aimed to assess the effect of MSC-derived exosomes (MSC-Exo) on the differentiation of peripheral blood mononuclear cells (PBMCs) into Tregs from patients with COVID-19.
Exosomes were isolated from adipose tissue–derived MSCs. PBMCs were separated from the whole blood of COVID-19 patients (n=20). Treg frequency was assessed before and 48 hours after treatment of PBMCs with MSC-Exo using flow cytometry. Expression of FOXP3 and cytokine genes, and the concentration of cytokines associated with Tregs, were assessed before and after treatment with MSC-Exo.
The frequency of CD4+CD25+CD127- Tregs was significantly higher after treating PBMCs with MSC-Exo (6.695±2.528) compared to before treatment (4.981±2.068). The expressions of transforming growth factor (TGF)-β1, interleukin (IL)-10, and FOXP3 were significantly upregulated in MSC-Exo–treated PBMCs. The concentration of IL‐10 increased significantly after treatment (994.7±543.9 pg/mL) of PBMCs with MSC-Exo compared with before treatment (563.5±408.6 pg/mL). The concentration of TGF-β was significantly higher in the supernatant
of PBMCs after treatment with MSC-Exo (477.0±391.1 pg/mL) than PBMCs before treatment (257.7±226.3 pg/mL).
MSC-Exo has the potential to raise anti-inflammatory responses by induction of Tregs, potentiating its therapeutic effects in COVID-19.
Effect of moisture content of recycled aggregates on workability, compressive strength and durability of concrete-A review
Authors: Lu Jun , Bao Deming , Jin Mingyang , Li Ran , Gao Yueqing , Hou Shaodan , Liang Chaofeng 
Published: June 2023

It is necessary to clarify the influence of different moisture contents of recycled aggregates (RA), including oven dry (OD), saturated surface dry (SSD), air dry (AD), etc., on the performance of recycled aggregate concrete (RAC) considering the time-dependent water absorption characteristic of RAs. By analyzing the previous literature, the effects of different moisture contents of RAs on the workability, compressive strength, and durability of RAC were discussed in detail. In addition, the microscopic mechanism was revealed based on the microstructure analysis. A lot of studies have shown that RAC prepared with RA in OD state had the largest fluidity when the same additional water was used. The slump loss of RAC decreases with the increase of water content of RAs, and when the moisture content of RA is higher than 50% of the water absorption of SSD, the slump loss is related to the additional method. The compressive strength and durability of RAC prepared with RAs in AD state were better than that prepared with RA in OD or SSD state. The shrinkage of RAC prepared with RA in OD state was greater than that prepared with RA in the SSD or AD state.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KUNJUNGAN PROLANIS DI PUSKESMAS PERAWATAN WAAI MALUKU TENGAH
Authors: Parinussa Nenny , Tubalawony Syulce , Matulessy Rachel 
Published: June 2023

Prolanis adalah program yang berawal dari Disease Management Program, bertujuan mendorong pasien penyakit kronis untuk hidup lebih berkualitas dan optimal dan biaya pelayanan efektif efisien sehingga mencegah timbulnya komplikasi penyakit. Penelitian bertujuan untuk mengetahui Faktor-Faktor Yang Berhubungan Dengan Kunjungan Peserta Prolanis Di Puskesmas Perawatan Waai. Desain penelitian adalah survai analitik dengan pendekatan cross sectional. Hasil penelitian yang dilakukan pada 33 responden, didapatkan responden dengan keterjangkauan akses mudah dijangkau 95,2% . Responden dengan dukungan keluarga baik 95,0%. Dukungan keluarga kurang baik, kunjungan peserta prolanis kurang baik 76,9%. Peran petugas kesehatan baik 80,0%, responden dengan peran petugas kesehatan kurang baik, kunjungan peserta prolanis kurang baik 88,9% .Dari hasil statistik didapat bahwa ada hubungan yang signifikan antara keterjangkauan akses, dukungan keluarga dan peran petugas kesehatan dengan kunjungan peserta prolanis, dengan hasil uji Chi Square masing-masing didapat nilai p=0,000 artinya nilai p<0,05. Dari penelitian ini disarankan dapat memberi masukan bagi masyarakat yang terdaftar dalam peserta prolanis untuk selalu patuh dalam melakukan kunjungan kegiatan prolanis agar penyakit yang di derita masyarakat tidak akan meningakat menjadi lebih serius dan bertambah parah.
Kata Kunci : Keterjangkauan Akses, Dukungan Keluarga, Peran Petugas Kesehatan, Kunjungan Prolanis
THE STRATEGY TO SUSTAIN LIVELIHOOD DURING PANDEMIC: LESSON FROM CULINARY ENTREPRENEURS IN SALATIGA
Authors: Setiawan Rio , Lasso Aldi Herindra 
Published: June 2023

During the COVID-19 pandemic, sustainability of tourism-related livelihood is significantly deterred. Tourism-related SMEs, including culinary businesses, struggle to find ways to survive the pandemic. Thus, strategies to cope with the crisis becomes an important issue to elaborate. This study provides an empirical case of such struggle by presenting a case of culinary business in Salatiga, Central Jawa, Indonesia. Based on qualitative approach, this research investigates strategies of the culinary entrepreneurs to cope with the COVID-19 pandemic. Data are collected through interviews, observations and document studies. Findings show that although culinary entrepreneurs currently manage to survive, they have to struggle to maintain their livelihood. As the end of the pandemic is still unpredictable, the sustainability of their livelihood remains vulnerable.
Effects on Soil Chemical Properties Two Years after Application of Compost in a Hedged Olive Grove
Authors: Alexandre Carlos A. , Lopes Rui Bajouco , Leal Jacqueline S. , Peça José O. , Dias And António B. 
Published: June 2023

Soil amendments with composted organic materials are recommended to increase soil organic matter (SOM), promote soil fertility, and the Circular Economy. Growing areas of hedged olive groves in southern Iberia peninsula generate huge amounts of olive leaves whose potential as soil organic amendment is not fully studied. An experimental field trial in a hedged olive grove (cv. “Cobrançosa”) was set up near Portalegre, Portugal, to test a compost of olive leaves plus sheep manure (2:1) applied in the row, at soil surface. Three nominal rates (0 or control, 2.5 and 5.0 kg m-2) were used, in a complete randomized block setup (3 treatments, 3 replicas, 9 plots) and soil chemical properties of layers 0-5, 5-15, and 15-30 cm deep were annually monitored. Results (mainly in layer 0-5 cm) showed increases in total N, carbon of the particulate organic matter (POM-C), permanganate oxidizable carbon (POX-C), extractable phosphorus, and zinc, after one year, and increases in soil organic carbon (SOC), C-stock, pHKCl, extractable phosphorus, and zinc, after two years. POX-C was the most sensitive SOM-related indicator, showing increases up to 30 cm deep after one year. This compost improved soil fertility, but should be monitored over longer periods of time, namely for SOC and extractable zinc content.
Simulation of Retrospective Morphological Channel Adjustments Using High-Resolution Differential Digital Elevation Models versus Predicted Sediment Delivery and Stream Power Variations
Authors: Conesa-García Carmelo , Martínez-Salvador Alberto , Puig-Mengual Carlos , Martínez-Capel Francisco , Pérez-Cutillas Pedro 
Published: June 2023

This work proposes a methodological approach applied to ephemeral gravel-bed streams to verify the change in the magnitude and frequency of hydrological events affecting the morphological dynamics and sediment budget in this type of channel. For the case study the Azohía Rambla, located in southeastern Spain, was chosen, emphasizing the research on two reference riverbed sections (RCRs): an upper one, with a predominance of erosion, and a middle one, where processes of incision, transport, and deposition converge. First, this approach focuses on relationships between peak discharges and sediment budgets during the period 2018 to 2022. For this purpose, water level measurements from pressure sensors, a One-Dimensional Hydrodynamic model, and findings from comparative analyses of high-resolution differential digital elevation models (HRDEM of Difference - HRDoD) based on SfM-MVS and LiDAR datasets were used. In a second phase the GeoWEPP model was applied to the period 1996-2022 in order to simulate runoff and sediment yield at the event scale for the watersheds draining into both RCRs. During the calibration phase a sensitivity analysis was carried out to detect the most influential parameters in the model and to confirm its capacity to simulate peak flow and sediment delivery in the area described above. Values of NS (Nash-Sutcliffe efficiency) and PBIAS (percent bias) equal to 0.86 and 7.81%, respectively, were found in the calibration period, while these indices were 0.81 and -4.1% in the validation period. Finally, different event class patterns (ECPs) were established for the monitoring period (2018-2022), according to flow stage and morphological channel adjustments (overtopping, bankfull and sub-bankfull, and half-sub-bankfull), and then retrospectively extrapolated to stages of the prior simulated period (1996-2018) from their typical sequences (PECPs). The results revealed a significant increase in the number of events and PECPs leading to lower bed incision rates and higher vertical accretion, which denotes a progressive increase in bed armoring and bank erosion processes.
Enhancing the Glacial Lake Inventory in Bhutan through Semi-Automatic Techniques using Google Earth Engine and QGIS for the Phochhu Basin
Authors: Selden Chimi , Selden Chimi , Norbu Rinchen 
Published: June 2023

Bhutan located in the Hindu Kush Himalayan (HKH) region consists of several glaciers and glacial lakes at higher elevations. With the rapid change in global temperature, glaciers are found to melt at an accelerated rate. This rapid melt of glaciers gets accumulated in weak moraine walls forming a glacial lake, posing a major threat to the downstream communities. As per the Bhutan Glacial Lake Inventory 2021, Bhutan has 567 glacial lakes. Furthermore, the Phochhu basin has the maximum glacial lakes (0.05%) and of which 9 are PDGL. Hence a need for a time monitoring system is imminent. With the availability of free High-resolution Satellite Imageries and Advanced Remote Sensing tools, it has been a sine qua no for monitoring glacial lakes in high areas. Therefore, using the Google Earth Engine and Qgis Platform a semi-automated technique was used to generate glacial lake inventories for Phochhu Sub-basin for the year 2021. We found out that there are 166 glacial lakes covering an area of 24.051 km2.
Current Information on <i>Capsicum frutescens</i>: A Critical Review of Pharmacological Potential
Authors: Chinnkar Meetali , Jadhav Pratima 
Published: June 2023

Capsicum frutescens is a species of the Solanaceae family of the genus Capsicum, which has around 20 species, five of which are regularly cultivated: “Capsicum annuum, Capsicum baccatum, Capsicum chinense, Capsicum frutescens, and Capsicum pubescens.” Since ancient times, C. frutescens has been used to taste and colour food all throughout the world. However, it is also employed for its medical benefits by many civilizations all over the world. This prompted researchers to concentrate on its chemical components, which led to a number of studies. The components isolated from C. frutescens such as capsaicinoids, carotenoids, and saponins authenticated its antibacterial, antidiabetic, anti-fungal, cardiovascular, thrombolytic, anti-cancer, and anti-oxidant activities along with a few more through various studies. This review focuses on all the pharmacological properties of these components highlighting the significance of Capsicum frutescens in herbal medicine.
Ghana’s Digital Addressing Design - Reality Gulf
Authors: Kubuga Kennedy Kumangkem , Ofori Philomina Pomaah , Abiam Solomon , Nantogmah Frederick , Ayoung Azerikatoa Daniel 
Published: June 2023

Abstract
Purpose
The research set out to review the implementation of Ghana’s efforts at implementation of a Digital Addressing System. Nearly six years into implementation and without outward appearance of the meeting of the announced goals of the project, the research sets out to find out the likelihood of success or failure of the project and suggest remedial measures.
Methods
Using a variety of quantitative and qualitative techniques the study assessed the implementation of the policy employing interviews, surveys, workshops and group discussion. It hinged on the Design-Reality Gap (DRG) model to identify the issues of interest with Ghana's digital addressing systems.
Results
We found out that the attempts, although well intended, fall short in several best practice aspects. The research found it difficult to confidently showcase any immediate successes arising out of the implementation of the GhanaPostGPS App and System and proceeds to point out specific areas in need of attention if Ghana’s Digital Addressing efforts are to meet the presumptive goals.
Conclusion
The Digital Addressing System might be a partial failure unless action is taken to close design-reality gaps.
Glycemic Control in People With Type 2 Diabetes Mellitus Seen in Primary Care During the Covid-19 Pandemic
Authors: VILANOVA CARLOS DALTON DE AVILA , Sporquio Natasha Gazzolla , Barcelos Laureana de Quevedo , Marques Clandio Timm , Colpo Elisangela 
Published: June 2023

Abstract
Purpose:
In Brazil, diabetes mellitus represents 8.8% of the population between 20 and 79 years of age. Disease control is associated with adherence to healthy lifestyle habits, promoting adequate glycemic control monitored by glycated hemoglobin. Therefore, the objective of this study was to analyze the glycemic control of people with Type 2 Diabetes Mellitus during the COVID-19 pandemic.
Material and methods:
The present research was a cross-sectional descriptive study. Through glycated hemoglobin, it evaluated the glycemic control of people with Type 2 Diabetes Mellitus during two periods of the pandemic. The first period was from March 2020 to June 2021, and the second was from July 2021 to February 2022.
Results:
There was a significant reduction in glycated hemoglobin from 8.4% in the pandemic period to 8% (p=0.035) in the stabilization period. This reduction was most evident in the group with glycated hemoglobin ≥7 in the pandemic period (p=0.007) and among women (p=0.008). The group who reduced their consumption of ultra-processed foods lowered a glycated hemoglobin from 8.3% to 7.6% (p=0.010), and those who used antidepressants decreased it from 7.6% to 7% (p=0.032).
Conclusion:
A reduction in the glycated hemoglobin of people with Type 2 Diabetes Mellitus occurred during the COVID-19 pandemic.
Is central venous catheter in haemodialysis still the main factor of mortality after hospitalization?
Authors: Campos Erwin , Cuevas-Budhart Miguel Angel , Cedillo-Flores Renata , Candelario-López Julian , Jimenez Rigoberto , Flores-Almonte Alberto , Ramos-Sanchez Alfonso 
Published: June 2023

Abstract

Background
Haemodialysis is the most used Renal Replacement Therapy modality worldwide. But patients undergoing this treatment have an unpredictable evolution related to vascular access.
Objective
To determine the factors associated with the mortality and hospitalization rate in haemodialysis patients at a third-level care Center in the Dominican Republic.
Methods
This was an observational and prospective study involving a cohort of 192 haemodialysis patients. The patient selection was non-probabilistic for convenience, and a direct source questionnaire was applied.
Results
Of the 192 patients in the cohort, 103 (53.6%) were hospitalized and analysed. The most frequent cause of hospitalization was catheter-related bloodstream infections (53.4%). Almost one-third (28.2%) of the hospitalized patients died, mostly from infections13 (12.6%). Of those who died 29 patients, 90% had a Central venous catheter (CVC) with a non-tunnelled catheter (NTC) (65.5%). Having an NTC CVC makes a patient 85.5 times more likely to be hospitalized than patients with arteriovenous fistulas.
Conclusion
Vascular access plays a predominant role in the hospitalization and mortality rates in haemodialysis. Patients with an arteriovenous fistula obtained better outcomes than those with central venous catheters.
Sinus arrest associated with diabetic ketoacidosis regressing to sinus rhythm after compensation of diabetic process: A case report and literature review
Authors: Bouchaala Abderrahmane , Nguadi Jaouad , Mouine Najat , Bouzelmat Hicham , Benyass Aatif 
Published: June 2023

Abstract
Background Diabetic ketoacidosis (DKA) is a serious life-threatening condition due to its profound hydro electrolytic disturbances and multiple complications, notably cerebral edema and circulatory collapse. Conductive disorders occurring during its course, such as sinus arrest, are poorly reported and can be life-threatening on their own in the absence of adequate recognition and treatment. Our effort through this report was raising awareness of unusual conduction complications of diabetic ketoacidosis and showing the importance of early diagnosis and treatment.
Case presentation we present the case of a middle-aged man with past history of type 2 diabetes whose symptoms included asthenia and consciousness disorder concomitant with ketoacidosis decompensation. Electrocardiogram (ECG) revealed the presence of sinus arrest with ventricular escaping rhythm. The rapid management of the diabetic decompensation resulted in spontaneous return to sinus rhythm, thus avoiding permanent pacing for the patient.
Conclusions Atypical complications during ketoacidosis decompensation, such as sinus arrest, are often overlooked and associated with reserved prognosis. Proper recognition and prompt treatment are crucial for optimal outcome.