bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report of autosomal dominant hypophosphatemic rickets due to a mutation in the FGF23 gene in an adult: diagnostic difficulties
Authors: Sakhnova E. E. , Przhiyalkovskaya E. G. , Mamedova E. O. , Chugunov I. S. 
Published: January 2025

Osteomalacia is a systemic disease of the skeleton, accompanied by the formation of an unmineralized or poorly mineralized osteoid instead of full-fledged bone tissue. The most common cause is severe vitamin D and calcium deficiency, phosphorus deficiency (kidney pathology, mesenchymal tumors secreting an excess of FGF23, genetic diseases). Among inherited pathologies, X-linked dominant hypophosphatemic rickets (XLHR, gene PHEX, OMIM: 307800) is the most frequent form, while autosomal dominant hypophosphatemic rickets (ADHR, gene FGF23, OMIM: 193100) and autosomal recessive hypophosphatemic rickets 1,2 (ARHR1-2, genes DMP1, ENPP1, FAM20C, OMIM: 241520, OMIM: 613312) are much less common. ADHR is an extremely rare form of genetic rickets caused by mutations in the FGF23 gene. It can manifest at any age. About 50 cases of this disease have been reported in the literature. This article presents the first clinical case of ADHR in an adult in the Russian Federation. Severe vitamin D deficiency, renal tubular disorders and tumor-induced osteomalacia were excluded in differential diagnosis. The patient underwent a genetic test, which revealed a mutation in the FGF23 gene and confirmed the diagnosis of ADHR. Therapy with an active vitamin D analog and phosphate supplement was initiated, after which the patient noticed decreased pain when walking and increased muscle strength.Difficulties in diagnosing osteomalacia are due to the lack of routine determination of serum phosphate and low awareness of doctors about this disease. In some cases, genetic tests make it possible to confirm hereditary forms, which prevents unnecessary surgical treatment, ensures timely prescription of therapy and significantly improves the quality of patients’ lives.
Refining the network for the Chinese analytic causative constructicon: insights from corpus analysis and psycholinguistic experimentation
Authors: Tian Xiaoyu 
Published: January 2025

Abstract
This study explores the network of the Chinese analytic causative constructicon adopting a cross-variety perspective. Unlike prior research focusing solely on the causative marker, this study acknowledges the multi-level nature of the constructicon and examines the descriptive causative construction identified by Zhang, Lili. (2005. Cong shiyi dao zhishi [The causativisation of Chinese shi-yi constructions]. Taida Wenshi Zhexue Bao (62). 119–152), which features a syntactically specified causee slot and a semantically defined effect predicate slot, distinguishing it from general causatives. Combining corpus analysis and psycholinguistic experimentation, our research reveals a consistent preference for using lìng as the causative marker within the descriptive causative construction, observed in both Mainland and Taiwan Chinese. By analyzing the syntactic and semantic features of the descriptive causative construction and its association with the causative marker lìng, we argue that this construction is stored at a separate level. Furthermore, we propose that the Chinese analytic causative constructicon is best represented by a radial network, accommodating both hierarchical and associative relationships, rather than a purely hierarchical structure as illustrated in Pijpops, Dirk, Dirk Speelman, Freek Van De Velde & Stefan Grondelaers. (2021. Incorporating the multi-level nature of the constructicon into hypothesis testing. Cognitive Linguistics 32(3). 487–528).
Compression Deformation and Collapsibility of Loess Subgrade Formed by Different Compaction Methods
Authors: Jiang Yingjun , Bai Chenfan , Zhang Yu , Fan Jiangtao , Yi Yong , Deng Changqing 
Published: January 2025

Abstract
Subgrades constructed from loess—a loose and porous material—demonstrate significant compressibility and collapsibility. To study these properties of loess subgrades, this article proposes a vertical vibration compaction method (VVCM) that provides a reliable simulation of field compaction and investigates the factors influencing the deformation characteristics of loess subgrade by VVCM-prepared specimens. The results show that the correlation between the compression modulus of loess samples prepared by VVCM and that of core samples obtained from the construction site is more than 85 %. In addition, the deformation resistance of the VVCM sample is better than that of the traditional quasistatic compaction method (QSCM) sample. Under the same compaction factor and water content, the compressive modulus of VVCM sample is at least 10 % higher and its collapsibility coefficient is 10 % lower than that of QSCM sample. With the increase in compaction factor, the compression modulus increases and the collapsibility coefficient decreases, indicating improved resistance to compressive deformation and reduced susceptibility to collapse in loess. With the increase in water content, the compression modulus and collapsibility coefficient decrease, reflecting greater compressibility and increased collapse resistance in loess.
АЗОТСОДЕРЖАЩИЕ УГЛЕРОДНЫЕ НАНОТРУБКИ В КАЧЕСТВЕ ЭФФЕКТИВНОГО НОСИТЕЛЯ ДЛЯ СИНТЕЗА СТАБИЛЬНЫХ АТОМАРНЫХ МЕТАЛЛИЧЕСКИХ КАТАЛИЗАТОРОВ
Authors: ПОДЪЯЧЕВА О.Ю. , ИСМАГИЛОВ З.Р. 
Published: January 2025

Исследована возможность использования азотсодержащих углеродных нанотрубок (N-УНТ) в качестве носителя для синтеза атомарных палладиевых и платиновых катализаторов. Изучено влияние содержания металлов (0.2-2 мас. %) и метода нанесения (пропитка и осаждение) на дисперсность нанесенных Pd и Pt. Определены условия для получения 100%-го атомарного катализатора: использование предшественника металла в катионной форме и содержание металла менее 0.5 мас. %. Установлено увеличение частоты оборота реакции разложения муравьиной кислоты в газовой фазе для получения водорода в 4 раза на атомах металлов, стабилизированных на пиридиноподобных азотных центрах N-УНТ, по сравнению с наночастицами размером ~1 нм. Атомарные металлические катализаторы проявляют бóльшую селективность по водороду и позволяют уменьшить концентрацию CO более чем в 2 раза. Установлена стабильность Pdи Pt атомарных форм в ходе реакции, протекающей при повышенных температурах.
The possibility of using nitrogen-containing carbon nanotubes (N-CNTs) as a support for the synthesis of single atom palladium and platinum catalysts has been studied. The influence of metal content (0.2-2 wt%) and synthesis method (impregnation and deposition) on the dispersion of supported Pd and Pt was studied. The requirements for preparation of a 100 % single atom catalyst have been determined (use of a metal precursor in cationic form and a metal content of less than 0.5 wt%). It was established that the turnover frequency of the gas-phase formic acid decomposition reaction for hydrogen production increases by 4 times on single metal atoms stabilised on the pyridinic nitrogen centres of the N-CNTs, compared to nanoparticles with a size of ~1 nm. Single atom metal catalysts exhibit higher selectivity to hydrogen and make it possible to decrease the concentration of carbon monoxide by more than 2 times. The stability of Pd and Pt atomic species in the course of the reaction occurring at elevated temperatures has been established.
Polypharmacy, therapeutic inertia, and adherence of heart recipients to drug therapy
Authors: Muminov I. I. , Shevchenko A. O. , Poptsov V. N. , Koloskova N. N. , Yusova A. A. , Sakhovsky S. A. , Uvarova D. D. 
Published: January 2025

Heart transplantation remains the gold standard treatment for end-stage heart failure. Lifelong immunosuppressive and adjuvant therapy requires constant medical follow-up in order to optimize treatment regimens and increase the adherence of heart recipients to treatment.Objective: to study and adapt a method for systematic assessment of the complexity of treatment regimen using the MRCI index, and its link to long-term prognosis in heart recipients.Materials and methods. Results of the study were obtained by analyzing the data of heart recipients observed at the Consultative & Diagnostic Department, Shumakov National Medical Research Center of Transplantology and Artificial Organs (Shumakov Center). The Medication Regimen Complexity Index (MRCI) was used to assess drug therapy. In our study, polypharmacy was defined as taking five or more medications, and high-risk polypharmacy was defined as the use of more than eight medications. The heart recipients were divided into two groups based on how many medications they received daily.Results. The study included patients observed at the Consultative & Diagnostic Department, Shumakov Center from January 2008 to December 2017. The number of drugs taken by the patient at year 5 of follow-up was 9.2 ± 4.2. During the conducted data analysis, the mean total MRCI score was 48.72 ± 19.15 (from 32 to 70); medications used to treat comorbidities accounted for 42.9% of the total MRCI score, and immunosuppressive therapy accounted for 28.7%. The total MRCI score in the high-risk polypharmacy group was 58.49 ± 17.41; medications used to treat comorbidities accounted for 50.27% of the total MRCI score. The analysis revealed a correlation between the total MRCI score and the frequency of hospitalizations.Conclusions. Patient adherence to prescribed treatment is a predictor of favorable prognosis of event-free long-term survival, but low adherence and therapeutic inertness are associated with decreased quality of life, more frequent hospitalizations and higher risk of adverse events. With proper outpatient follow-up of this patient cohort, there were no significant differences in survival in the polypharmacy and high-risk polypharmacy group.
Effect of prolonged cardiac graft preservation on adhesion protein activation and synthetic endothelial function
Authors: Zhulkov М. O. , Karmadonova N. A. , Surovtseva M. A. , Kim I. I. , Poveshchenko O. V. , Zykov I. S. , Tarkova A. R. , Sirota D. A. , Protopopov A. V. , Makaev A. G. , Kosimov F. Yu. , Murtazaliev M. N. , Guseva A. V. , Agaeva K. A. 
Published: January 2025

Objective: to conduct a comparative study of the efficacy of Custodiol® cardioplegia (Custodiol HTK, Dr. Franz Köhler Chemie GmbH, Bensheim, Germany) and normothermic autoperfusion of heart graft as a part of an ex vivo cardiopulmonary complex (CPC). Methods. Landrace pigs weighing 50 ± 5 kg and aged 4–5 months (n = 10) were used as the model for a series of acute experiments. In the experimental group (n = 5), the CPC was conditioned by autoperfusion for 6 hours. In the control group, the heart’s pumping function was restored after a 6-hour cold preservation with Custodiol®. The effectiveness of cardiac graft preservation methods was evaluated by measuring myocardial ischemic markers, endothelial synthetic function, and endothelial cell activation markers (E- and P-selectins, endothelial growth factor).Results. Following cardiac graft reperfusion, the control group exhibited a statistically significant increase in the concentration of myocardial ischemia markers; also, there was a significant decrease in the synthesis of endothelium-derived relaxing factor in the Custodiol® solution preservation group (378.5 [226.4; 539.7] vs. 542.1 [377.6; 853.2] μM/mL in the autoperfusion group, p < 0.05). The degree of coronary endothelial reperfusion injury/activation was several times higher in the control group than in the normothermic autoperfusion conditioning group. Moreover, cardiac output after a 6-hour graft conditioning was 0.63 [0.37; 0.80] and 0.37 [0.23; 0.37] L/min in the experimental and control groups, respectively (p < 0.05).Conclusion. Normothermic autoperfusion showed a significant advantage in preserving the morphofunctional status of the donor heart compared with cold preservation with Custodiol® during 6 hours of ex vivo graft conditioning.
Native liver fibrosis in pediatric liver recipients: association with genetic polymorphism in the TGFB1 gene
Authors: Tsirulnikova O. M. , Gichkun O. E. , Kurabekova R. M. , Stakhanov E. A. , Pashkova I. E. , Vakurova E. A. , Shevchenko O. P. 
Published: January 2025

Objective: to examine the relationship between native liver fibrosis and TGFB1 gene polymorphism in pediatric liver recipients.Materials and methods. Fibrosis of varying severity was diagnosed (METAVIR scale) based on histological analysis of the native liver of children (45 boys and 62 girls aged 3 to 73 months). Genomic DNA was genotyped by real-time polymerase chain reaction using TaqMan probes. Results. The prevalence of the TGFB1 single nucleotide polymorphisms (SNPs) rs1800469, rs1800470, and rs1800471 was examined in both children with liver fibrosis of varying severity and in healthy individuals. The distribution of rs1800470 in children with fibrosis was 50% homozygotes of major allele, 29% heterozygotes and 21% homozygotes of minor allele. This distribution was not consistent with the Hardy–Weinberg principle (p = 0.00026).Conclusion. Liver fibrosis in pediatric liver recipients is linked to the rs1800470 polymorphism of the TGFB1 gene. Carriage of the heterozygous rs1800470 genotype may be a protective factor against liver fibrosis in children with liver failure.
Bacterial translocation in deceased organ donors
Authors: Petkevich O. V. , Mitsura V. M. , Martinkov V. N. , Dugin D. L. , Dundarov Z. A. 
Published: January 2025

Objective: to ascertain the prevalence and risk factors for bacterial translocation (BT) in brain-dead donors (BDDs) during organ and tissue retrieval in health care facilities.Materials and methods. The study included 62 BDDs, featuring 44 males (71%) and 18 females (29%), aged 17 to 64 years. Organ was retrieved in healthcare institutions located in Gomel Oblast in 2019–2022. Bacteriological examination of biopsy material taken from different parts of the intestine, mesenteric lymph nodes (MLNs) and spleen was carried out. The presence of BT was validated when bacterial growth was obtained from homogenized MLNs and(or) spleen by isolating an identical strain from the intestinal lumen. The anthropometric characteristics of BDDs, hematologic, biochemical parameters, and the length of stay in the intensive care unit (ICU) were assessed.Results. Evidence of bacterial translocation was detected in 22 BDDs (35.5%, 95% CI 24.7–48.0). Growth in MLNs and in spleen biopsies was noted in 21 (95.5%) and 7 (31.8%) patients, respectively. The BDDs were categorized into two groups depending on the presence of BT, and the main characteristics were compared. ROC analysis was used to determine the prognostic significance of the main parameters. Risk factors for BT were serum sodium level >144 mmol/L (AUC = 0.759) at the time of retrieval, weight >89 kg (AUC = 0.756), BMI >27.5 (AUC = 0.709), decreased hemoglobin <126 g/L (AUC = 0.665), and ICU stay >2 days (AUC = 0.656).Conclusion. Bacterial translocation is found in 35.5% of BDD cases, and it is accompanied by penetration of bacteria and yeast-like fungi into the MLNs and spleen. Bacterial translocation is linked to excess body weight, hypernatremia, prolonged ICU stay, and decreased hemoglobin levels at the time of retrieval. These factors should be taken into account in the medical management of brain-dead donors (organ donor conditioning).
Promoting organ donation in Russia: problems and prospects
Authors: Komkova G. N. , Toguzaeva E. N. , Basova A. V. , Karamysheva M. S. 
Published: January 2025

Transplantation helps to save the lives of patients with end-stage diseases of the liver, heart, lungs, and kidney.Objective: to study the strategies for advancing the idea of organ donation in the Russian Federation.Materials and methods. Scholarly publications by Russian researchers on the issue at hand. The study’s methodology was based on application of general and specific scientific methods of theoretical analysis.Results. An assessment of how opportunities were used to legitimately promote the idea of donation was conducted.Conclusion. Modern ways and methods of promoting the idea of organ donation will help to introduce into public attention the importance of organ donation for transplantation.
Experimental study of a new dextran-40-based combined solution on a small laboratory animal model
Authors: Grudinin N. V. , Bogdanov V. K. , Pashkov I. V. , Esipova O. Yu. , Kuleshov A. P. , Mozheiko N. P. , Volkova E. A. , Gautier S. V. 
Published: January 2025

Background. Organ shortage remains an unsolved issue in the field of transplantology. It is particularly severe in such a progressive area as lung transplantation. The creation of extracorporeal systems for rehabilitation of donor organs has been made possible by perfusion techniques; however, the search for the best perfusion and preservation solutions remains important.Objective: to evaluate the efficacy of the developed solution for preservation and normothermic ex vivo lung perfusion (EVLP), as well as to conduct a comparative analysis with the standard perfusion solution for EVLP.Materials and methods. Experimental studies on small animal models were conducted. All animals were divided into 2 groups – control and experimental. The study stages consisted of: procurement of donor lungs, static cold storage, EVLP and orthotopic left lung transplantation. In the experimental group, the lungs were preserved using an experimental solution, while in the control group, they were preserved in PERFADEX® Plus (XVIVO, Sweden). Static cold storage lasted for 10 hours. Orthotopic left lung transplantation was performed after EVLP. The follow-up period was 2 hours, after which blood samples and sections of the transplanted lung were taken for morphological examination. Upon completion of the experiment, the animal was removed from the experiment by exsanguination.Results. Respiratory index at the end of perfusion was statistically significantly higher in the experimental group (434 mmHg) than that of the control group (394 mmHg). Pulmonary vascular resistance (PVR) in both groups had a downward trend, which is a good prognostic sign of the efficacy of perfusion agents. PVR was lower in the experimental group compared to the control group – 36 versus 89 dynes/sec/cm–5.Conclusion. The developed combined dextran-40-based solution showed its effectiveness as a preservation agent for static cold storage and as a perfusion solution for EVLP.
Development Law and Prevention Methods of Mining-induced Ground Cracks: A Review
Authors: Zhang Yanjun , Yan Yueguan , Zhu Guizhen , Zhu Yuanhao , Kong Jiayuan , Fang Kun 
Published: January 2025

ABSTRACT
Mining-induced ground cracks in coal mining areas pose a significant threat to the ecological environment and the safety of individuals and property. To achieve sustainable development in mining environments and resource utilization, it is crucial to elucidate the formation mechanisms, types, development laws, research methods, and prevention strategies associated with ground cracks. In this paper, we classify mining-induced ground cracks based on various research purposes. Relevant research methods are summarized, and we systematically review the research progress on the development law of different mining-induced ground cracks. The unique development patterns of ground cracks in the Aeolian sand area of the western mining region in China are analyzed, highlighting a double cycle. Simultaneously, we explore prevention methods for mining-induced ground cracks. Results indicate that the evolution law and formation mechanism of mining-induced ground cracks are influenced by various geological and mining factors, showing complexity, diversity, and unity. However, research methods have their limitations. Building upon these findings, we propose a monitoring and analysis systems for mining-induced ground cracks to enhance real-time monitoring, data processing, and subsequent analysis. It is recommended to make further efforts in seven aspects. These endeavors aim to better comprehend the intricate behavior of ground cracks in coal mining areas, providing a theoretical reference for land ecological restoration.
Precipitation of Chromium Acetate Solutions
Authors: Zou B. , McCool C.S. , Green D.W. , Willhite G.P. , Michnick M.J. 
Published: January 2025

Abstract
Chromium(III)-polymer systems are often used in permeability modification treatments. The transport of chromium(III) in-depth in porous rocks is sometimes limited due to precipitation. Precipitation is caused by the increase in the solution pH because of fluid-rock interactions, particularly in carbonate rocks. This paper presents experimental data on the rate of precipitation of chromium from chromium(III) acetate solutions. Experimental data were obtained for the precipitation of chromium from chromium acetate solution at constant pH. Data were obtained as a function of pH, temperature, salinity and OAc/Cr ratio. The pH range studied was between 7 and 10, and the temperature range was between 25 and 45°C. Precipitation of chromium was preceded by an induction period where there was no change in concentration. The induction period decreased from 1200 minutes at pH 7 to less than 200 minutes at pH 10 at 25°C. A higher temperature increased the precipitation rate. Precipitation is delayed by the addition of acetate ion. Both the salinity and salt type have significant effects on the rate of precipitation. A kinetic model was developed to describe both the induction period and the rate of precipitation of chromium from a chromium acetate solution in 1% KCl at 25°C for a pH range of 7-10 with OAc/Cr ratios between 3 and 9.
Less Aerosols Cause Global Warming in the Last Two Decades
Authors: Lu Qing-Bin 
Published: January 2025

Abstract

In most climate models, warming in global mean surface temperature (GMST) in the last two decades is mainly attributed to rising CO2. Here we present observed data of regional and global upper stratosphere temperature (UST) and surface temperature and of various climate drivers including greenhouse gases (GHGs), ozone, aerosols, solar variability, snow cover extent, and sea ice extent (SIE), combined with calculations of GMST by a conceptual physics model. We strikingly found warming trends of 0.8(+/-0.6) and 0.7(+/-0.2) K/decade in UST at altitudes of 35-40 km in the Arctic and Antarctic respectively and no significant trends over non-polar regions since 2002. Correspondingly, surface temperatures exhibit cooling trends in the Antarctic since 2002 and in the Arctic since 2016 when the SIE started to stabilize, no trend in the tropics, and warming trends at Southern and Northern mid-latitudes respectively. The latter warming causes the recent rise in GMST, which is well explained by the positive radiative forcings of aerosols and ozone associated with improved air quality. According to well-recognized climate models, the observed UST trends provide fingerprints of decreasing (no significant increase) in total GHG effect in polar (non-polar) regions. A coherent global phenomenon observed in both UST and surface temperature has emerged, which agrees well with calculated results by the warming model based on halogen-containing GHGs (halo-GHGs). With observations of rapidly lowered aerosol loading, projected halo-GHGs and stopped Arctic amplification, this study leads to a striking prediction of a GMST reversal, which will likely occur within next 5-10 years.