bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small RNA Sequencing Reveals a Distinct MicroRNA Signature between Glucocorticoid Responder and Glucocorticoid Non-responder Primary Human Trabecular Meshwork Cells after Dexamethasone Treatment
Authors: Kathirvel Kandasamy , Fan Xiaochen , Haribalaganesh Ravinarayanan , Bharanidharan Devarajan , Sharmila Rajendrababu , Krishnadas Ramasamy , Muthukkaruppan Veerappan , Willoughby Colin E. , Senthilkumari Srinivasan 
Published: June 2023

AbstractThe present study aimed to understand the role of miRNAs in differential glucocorticoid (GC) responsiveness in human trabecular meshwork (HTM) cells using small RNA sequencing. For this, total RNA was extracted from cultured HTM cells with known GC responsiveness using Human organ-cultured anterior segment (HOCAS) (GC-responder GC-R; n=4) and GC-non-responder (GC-NR; n=4) after treatment with either 100nM dexamethasone (DEX) or ethanol (ETH) for 7 days. Differentially expressed miRNAs (DEMIRs) were compared among 5 groups and validated by RT-PCR. There were 13 and 21 DEMIRs identified in Group #1 (ETH vs DEX-treated GC-R) and Group #2 (ETH vs DEX-treated GC-NR) respectively. Seven miRNAs were found as common miRNAs dysregulated in both GC-R and GC-NR (Group #3). There were 6 and 14 unique DEMIRs were identified in GC-R (Gropu#4) and GC-NR (Group#5) HTM cells respectively. Ingenuity Pathway Analysis identified enriched pathways and biological processes associated with differential GC responsiveness in HTM cells. Integrative analysis of miRNA-mRNA of the same set of HTM cells revealed several molecular regulators for GC non-responsiveness. This is the first study revealed a unique miRNA signature between GC-R and GC-NR HTM cells which raises the possibility of developing new molecular targets for the management of steroid-OHT/glaucoma.
The BharatPe debacle: growth at the cost of governance?
Authors: Datta Shyamal , Goyal Sonu 
Published: June 2023

Learning outcomes
The case is aimed at providing students with an opportunity to understand various aspects of corporate governance and the consequences of poor corporate governance. The case addresses the following objectives: The students need to assess the role of the board in implementing corporate governance. The students should be able to explain the conflicts experienced by various stakeholders in an organization. The students need to evaluate the balancing act of growth and governance in a startup. The students should be able to determine the current state of business sustainability of the high-growth startups in India.

Case overview/synopsis
The case presents the challenges faced by the CEO of BharatPe, Suhail Sameer. Beginning in 2022, Bharatpe was in deep trouble as there were allegations of financial mismanagement, toxic work culture and widening losses. Co-founder Ashneer Grover and his wife Madhuri had to leave the company following charges against them. As Grover was the face of the company, Sameer would have to quickly act on filling the void and reassuring investors. Because of the uncertainty, scores of employees had already quit or were looking for other jobs. Questions were also raised about the board’s inaction and lack of proactive measures. After a meteoric rise for three years, BharatPe was struggling to survive the whole episode and put its focus back on business.

Complexity academic level
The case is intended for MBA students in corporate governance, organizational behaviour, business ethics and strategic management areas. As the case reveals the impact of poor corporate governance, it can also be used for executive training purposes on corporate sustainability, governance and leadership with a special focus on Indian startups.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy.
Do financial anxiety and generalized anxiety mediate the effect of perceived organizational support on service employees’ career commitment?
Authors: Karatepe Osman M. , Çolakoğlu Ülker , Yurcu Gülseren , Kaya Şule 
Published: June 2023

Purpose
This paper aims to explore financial anxiety and generalized anxiety as the serial mediators linking perceived organizational support (POS) to career commitment.

Design/methodology/approach
Data were collected from 388 managerial and nonmanagerial employees in diverse service areas, such as restaurants, airlines and hotels in Turkey. The direct and mediating effects were tested via the PROCESS macro.

Findings
Financial anxiety partly mediates the impact of POS on career commitment. The findings further reveal that financial anxiety and generalized anxiety serially mediate the effect of POS on career commitment.

Practical implications
Management should work with mentors to provide employees with psychosocial support during the COVID-19 pandemic. When employees perceive that the firm really cares about them and values their contribution during these challenging days, they display lower anxiety and higher career commitment. Management should also retain employees who are high on career commitment because such employees possess a sense of calling and are unlikely to quit. These implications may not be considered new. However, management would need such employees concerning the firm’s performance recovery after COVID-19.

Originality/value
Workers in the service industries suffer from financial and generalized anxieties and display reduced career commitment during COVID-19. However, little is known about the antecedents and outcomes of financial anxiety among hospitality and tourism workers. More importantly, no empirical piece has tested these anxiety variables as the mediators linking POS to career commitment in the pertinent literature so far.
The “dark side” of Industry 4.0: How can technology be made more sustainable?
Authors: Dieste Marcos , Orzes Guido , Culot Giovanna , Sartor Marco , Nassimbeni Guido 
Published: June 2023

PurposeA positive outlook on the impact of Industry 4.0 (I4.0) on sustainability prevails in the literature. However, some studies have highlighted potential areas of concern that have not yet been systematically addressed. The goal of this study is to challenge the assumption of a sustainable Fourth Industrial Revolution by (1) identifying the possible unintended negative impacts of I4.0 technologies on sustainability; (2) highlighting the underlying motivations and potential actions to mitigate such impacts; and (3) developing and evaluating alternative assumptions on the impacts of I4.0 technologies on sustainability.Design/methodology/approachBuilding on a problematization approach, a systematic literature review was conducted to develop potential alternative assumptions about the negative impacts of I4.0 on sustainability. Then, a Delphi study was carried out with 43 experts from academia and practice to evaluate the alternative assumptions. Two rounds of data collection were performed until reaching the convergence or stability of the responses.FindingsThe results highlight various unintended negative effects on environmental and social aspects that challenge the literature. The reasons behind the high/low probability of occurrence, the severity of each impact in the next five years and corrective actions are also identified. Unintended negative environmental effects are less controversial than social effects and are therefore more likely to generate widely accepted theoretical propositions. Finally, the alternative hypothesis ground is partially accepted by the panel, indicating that the problematization process has effectively opened up new perspectives for analysis.Originality/valueThis study is one of the few to systematically problematize the assumptions of the I4.0 and sustainability literature, generating research propositions that reveal several avenues for future research.
A resource orchestration perspective of organizational big data analytics adoption: evidence from supply chain planning
Authors: Xu Jinou , Pero Margherita Emma Paola 
Published: June 2023

PurposeThis paper investigated the organizational adoption of big data analytics (BDA) in the context of supply chain planning (SCP) to conceptualize how resources are orchestrated for organizational BDA adoption and to elucidate how resources and capabilities intervene with the resource management process during BDA adoption.Design/methodology/approachThis research elaborated on the resource orchestration theory and technology innovation adoption literature to shed light on BDA adoption with multiple case studies.FindingsA framework for the resource orchestration process in BDA adoption is presented. The authors associated the development and deployment of relevant individual, technological and organizational resources and capabilities with the phases of organizational BDA adoption and implementation. The authors highlighted that organizational BDA adoption can be initiated before consolidating the full resource portfolio. Resource acquisition, capability development and internalization of competences can take place alongside BDA adoption through structured processes and governance mechanisms.Practical implicationsA relevant discussion identifying the capability gap and provides insight into potential paths of organizational BDA adoption is presented.Social implicationsThe authors call for attention from policymakers and academics to reflect on the changes in the expected capabilities of supply chain planners to facilitate industry-wide BDA transition.Originality/valueThis study opens the black box of organizational BDA adoption by emphasizing and scrutinizing the role of resource management actions.
Theoretical and experimental study of a novel triple-magnet magnetic dynamic vibration absorber with tunable stiffness
Authors: Chen Xiaoyu , Leng Yonggang , Sun Fei , Su Xukun , Sun Shuailing , Xu Junjie 
Published: June 2023

PurposeThe existing Nonlinear Dynamic Vibration Absorbers (NLDVAs) have the disadvantages of complex structure, high cost, high installation space requirements and difficulty in miniaturization. And most of the NLDVAs have not been applied to reality. To address the above issues, a novel Triple-magnet Magnetic Dynamic Vibration Absorber (TMDVA) with tunable stiffness, only composed of triple cylindrical permanent magnets and an acrylic tube, is designed, modeled and tested in this paper.Design/methodology/approach(1) A novel TMDVA is designed. (2) Theoretical and experimental methods. (3) Equivalent dynamics model.FindingsIt is found that adjusting the magnet distance can effectively optimize the vibration reduction effect of the TMDVA under different resonance conditions. When the resonance frequency of the cantilever changes, the magnet distance of the TMDVA with a high vibration reduction effect shows an approximately linear relationship with the resonance frequency of the cantilever which is convenient for the design optimization of the TMDVA.Originality/valueBoth the simulation and experimental results prove that the TMDVA can effectively reduce the vibration of the cantilever even if the resonance frequency of the cantilever changes, which shows the strong robustness of the TMDVA. Given all that, the TMDVA has potential application value in the passive vibration reduction of engineering structures.
Source of funding and specialized competences: the impact on the innovative performance of start-ups
Authors: Errico Fabrizio , Messeni Petruzzelli Antonio , Panniello Umberto , Scialpi Angelo 
Published: June 2023

Purpose
This paper aims to explore the effects of two drivers, namely, the received fundings and its interaction with the specialized competences owned by the managerial board, on the R&D activities performed by start-ups.

Design/methodology/approach
This paper tests hypotheses on a sample of 405 innovative start-ups established in Italy and registered into the Chamber of Commerce official database. This study uses the R&D expenses as a measure of the innovative performance of start-up, and the authors also collected the number and total amount of grants received by them and the presence of high qualified team in their management board.

Findings
The analysis reveals that both the number and total amount of grants received by start-ups positively impact the innovative performance. The same is for the integration of the total amount of grants with the presence of high qualified team in the management board.

Research limitations/implications
This study did not distinguish between different types of grants adopted by start-ups, while it would be interesting to study whether any difference does exist among them in terms of their influence on innovative performance. Also, this paper considers the total number of specialized people in the team while it would certainly be interesting to analyze people’s background and competences in relation to the innovative performances.

Practical implications
This paper allows us to offer some provisional conclusions such as having funds in the preliminary phase of start-up life cycle, and investments mainly for R&D expenses. The start-up must also leverage its skills and therefore it is necessary to invest in human capital.

Social implications
Findings suggest that policymakers should introduce integrated measures to support start-ups throughout the entire life cycle, from the creation of the idea to incubation up to industrial consolidation.

Originality/value
This paper focuses on the determinants of start-up innovative performance because both external (such as political, economic, social and technological) and internal (such as organizational) influencing factors have to be considered as crucial for start-ups innovation and growth. Finally, this study is one of the few attempts exploring the phenomenon by using an empirical methodology based on real and certificated data.
Research collaboration amongst Egyptian library and information science faculty members
Authors: Mansour Essam 
Published: June 2023

PurposeThe purpose of this study is to determine the potential for research collaboration amongst Egyptian library and information science (LIS) faculty members.Design/methodology/approachAn online survey was used, which ran from the beginning of June to the middle of July 2021.FindingsMale respondents made up slightly more than half of the total, with ages ranging from 30s to 40s and the majority holding PhDs. According to all respondents, the most important reasons for collaborating on research authorship were “to gain more experience”, followed by “to gain more knowledge”. More than half of respondents rated the collaborative research as “Good”, with “Very Good” coming in second. Almost all respondents stated the most common types of collaboration amongst the respondents were “a research paper”, “a case study”, “a review” and “a book chapter”. All faculty members stated that challenges such as “The research collaborator does not contribute equally to the same motivation” and “The research collaborator does not do what is expected of him/her to complete the research” were at the very least significant to the respondents.Practical implicationsThe findings of this study have significant implications for higher education research and publishing in Egypt, particularly in terms of encouraging collaborative research amongst Egyptian researchers, particularly in the field of LIS.Originality/valueThis is nearly the first study of the kind in the Arab and Egyptian contexts. This study is described as a pioneer amongst the studies concerned with this topic that were conducted in the field of joint authorship, especially at the local and regional levels, because this study is one of the few studies on partnership and research cooperation amongst Egyptian faculty members in the field of LIS.
Effects of season length and uniparental care efficacy on the evolution of parental care
Authors: Zheng Jia , Komdeur Jan , Weissing Franz J. 
Published: June 2023

Abstract

Parental care patterns differ enormously among and even within species. This is exemplified by Chinese penduline tits Remiz consobrinus, where biparental care, female‐only care, male‐only care and biparental desertion all occur in the same population; moreover, the distribution of these care patterns differs systematically between populations. The eco‐evolutionary determinants of this diversity are largely unknown.

We developed an individual‐based model that allows us to investigate the effects of season length and offspring needs (expressed by the efficacy with which a clutch can be raised by a single parent) on the evolution of parental care patterns. The model is largely conceptual, aiming at general conclusions. However, to keep the model realistic, its set‐up and the choice of parameters are motivated by field studies on Chinese penduline tits. Exploring a wide range of parameters, we investigate how parental care patterns are affected by season length and offspring needs and whether and under what conditions diverse parental care patterns can stably coexist.

We report five main findings. First, under a broad range of conditions, different care patterns (e.g. male care and biparental care) coexist at equilibrium. Second, for the same parameters, alternative evolutionary equilibria are possible; this can explain differences in care patterns across populations. Third, rapid evolutionary transitions can occur between alternative equilibria; this can explain the often‐reported evolutionary lability of parental care patterns. Fourth, season length has a strong but nonmonotonic effect on the evolved care patterns. Fifth, when uniparental care efficacy is low, biparental care tends to evolve; however, in many scenarios uniparental care is still common at equilibrium. In addition, our study sheds new light on Trivers' hypothesis that the sex with the highest prezygotic investment is predestined to invest more postzygotically as well.

Our study highlights that diversity in parental care can readily evolve and it shows that even in the absence of environmental change parental care patterns can be evolutionary labile. In the presence of directional environmental change, systematic shifts in care patterns are to be expected.
Evolution of concomitant use of veno‐arterial extracorporeal membrane oxygenation support with Impella in cardiogenic shock: From percutaneous femoral Impella to axillary Impella 5.5
Authors: Isath Ameesh , Ohira Suguru , Levine Avi , Lanier Gregg M. , Pan Stephen , Aggarwal‐Gupta Chhaya , Mason Ian , Gregory Vasiliki , Spielvogel David , Gass Alan L. , Kai Masashi 
Published: June 2023

AbstractBackgroundLittle is known about safety and efficacy of the use of Impella 5.5 compared to previous iterations in the setting of Impella with Veno‐Arterial Extracorporeal Membrane Oxygenation Support as ECPELLA.MethodsConsecutive patients who were treated by ECPELLA with surgically implanted axillary Impella 5.5 (N = 13) were compared with patients supported by ECPELLA with percutaneous femoral Impella CP or 2.5 (Control, N = 13).ResultsThe total ECPELLA flow was higher in ECPELLA 5.5 group (6.9 vs. 5.4 L/min, p = 0.019). Actual hospital survival was higher than predicted and comparable in both groups (ECPELLA 5.5, 61.5% vs. Control, 53.8%, p = 0.691). Both total device complications (ECPELLA 5.5, 7.7% vs. Control, 46.1%, p = 0.021) and Impella‐specific complications (ECPELLA 5.5, 0% vs. Control, 30.8%, p = 0.012) were significantly lower in the ECPELLA 5.5 group.ConclusionsUtilization of Impella 5.5 in the setting of ECPELLA provides greater hemodynamic support with a lower risk of complications compared to Impella CP or 2.5.
Nonmass‐forming type anorectal cancer with pagetoid spread: A report of two cases
Authors: Yamamoto Masahiro , Mizuuchi Yusuke , Tamura Koji , Sada Masafumi , Nagayoshi Kinuko , Nakata Kohei , Ohuchida Kenoki , Oda Yoshinao , Nakamura Masafumi 
Published: June 2023

AbstractPagetoid spread (PS) of anorectal cancer is relatively rare and associated with poor prognosis. While a primary tumorous lesion is usually obvious in most PS cases, we experienced two cases of nonmass‐forming type anorectal cancer with PS. It remains challenging to decide strategies. In both cases, histological findings of a perianal skin biopsy showed proliferation of atypical cells that were positive for cytokeratin (CK) 7, CK20, and caudal type homeobox 2 and negative for Gross cystic disease fluid protein 15, suggesting PS. Abdominoperineal resection (APR) with extensive anal skin resection was performed in both patients. The pathological diagnosis in each was nonmass‐forming type anorectal cancer with PS. Neither has experienced recurrence in postoperative courses. Even nonmass‐forming type anorectal cancer with PS could have high malignant potentials. APR with lymph nodes dissection and wide skin excision and regular surveillance might be necessary.
Response adaptive salvage with KTd and ASCT for functional high‐risk multiple myeloma—The Australasian Leukemia and Lymphoma Group (ALLG) MM17 Trial
Authors: Turner R. , Quach H. , Horvath N. , Kerridge I. , Lee E. , Morris E. , Kalff A. , Khong T. , Reynolds J. , Spencer A. 
Published: June 2023

SummaryWe evaluated re‐induction incorporating carfilzomib–thalidomide–dexamethasone (KTd) and autologous stem cell transplantation (ASCT) for newly diagnosed multiple myeloma (NDMM) refractory, or demonstrating a suboptimal response, to non‐IMID bortezomib‐based induction. KTd salvage consisted of thalidomide 100 mg daily and dexamethasone 20 mg orally combined with carfilzomib 56 mg/m2 days 1, 2, 8, 9, 15 and 16, of each 28‐day cycle. Following four cycles, patients achieving a stringent complete response proceeded to ASCT whereas those who did not received a further two cycles then ASCT. Consolidation consisted of two cycles of KTd then Td to a total of 12 months post‐ASCT therapy. Primary end‐point was the overall response rate (ORR) with KTd prior to ASCT. Fifty patients were recruited. The ORR was 78% with EuroFlow MRD negativity of 34% in the intention‐to‐treat population and 65% in the evaluable population at 12 months post‐ASCT. With follow‐up >38 months median PFS and OS have not been reached with PFS and OS at 36 months of 64% and 80%, respectively. KTd was well tolerated with grade 3 and grade ≥4 adverse events rates of 32% and 10%, respectively. Response adaptive utilisation of KTd with ASCT is associated with both high‐quality responses and durable disease control in functional high‐risk NDMM.
Spending reviews and the Government of Canada: From episodic to institutionalized capabilities and repertoires
Authors: Lindquist Evert A. , Shepherd Robert P. 
Published: June 2023

AbstractFollowing surges of spending and staff hiring to address the COVID‐19 pandemic, the Trudeau government announced a strategic policy review in the 2022 Budget to secure savings of $6 billion. There has been little apparent progress by May 2023 and opaque communications. This is surprising because Canada was once considered an international exemplar for spending reviews, needs to learn from the pandemic experience, has a worrisome medium‐to‐long‐term federal spending trajectory, and the governance and economic context has rapidly evolved. This article identifies different kinds of spending reviews and design considerations, reviews Canada's experience with reviews since the early 1980s, considers recent OECD experience and exemplars, and argues that its spending reviews have become increasingly selective and closed. We suggest the Canadian government should institutionalize annual spending reviews, which can be scaled up or down, and that this points to more fundamental issues for reform and building a new governance culture.