bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metric dimension of dual polar graphs
Authors: Bailey Robert F. , Spiga Pablo 
Published: March 2023

AbstractA resolving set for a graph $$\Gamma $$
Γ
is a collection of vertices S, chosen so that for each vertex v, the list of distances from v to the members of S uniquely specifies v. The metric dimension$$\mu (\Gamma )$$

μ
(
Γ
)

is the smallest size of a resolving set for $$\Gamma $$
Γ
. We consider the metric dimension of the dual polar graphs, and show that it is at most the rank over $$\mathbb {R}$$
R
of the incidence matrix of the corresponding polar space. We then compute this rank to give an explicit upper bound on the metric dimension of dual polar graphs, as well as the halved dual polar graphs.
The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots
Authors: Giannattasio Teresa , Testa Erika , Palombo Ramona , Chellini Lidia , Franceschini Flavia , Crevenna Álvaro , Petkov Petko M. , Paronetto Maria Paola , Barchi Marco 
Published: March 2023

AbstractIn mammals, meiotic recombination is initiated by the introduction of DNA double strand breaks (DSBs) into narrow segments of the genome, defined as hotspots, which is carried out by the SPO11/TOPOVIBL complex. A major player in the specification of hotspots is PRDM9, a histone methyltransferase that, following sequence-specific DNA binding, generates trimethylation on lysine 4 (H3K4me3) and lysine 36 (H3K36me3) of histone H3, thus defining the hotspots. PRDM9 activity is key to successful meiosis, since in its absence DSBs are redirected to functional sites and synapsis between homologous chromosomes fails. One protein factor recently implicated in guiding PRDM9 activity at hotspots is EWS, a member of the FET family of proteins that also includes TAF15 and FUS/TLS. Here, we demonstrate that FUS/TLS partially colocalizes with PRDM9 on the meiotic chromosome axes, marked by the synaptonemal complex component SYCP3, and physically interacts with PRDM9. Furthermore, we show that FUS/TLS also interacts with REC114, one of the axis-bound SPO11-auxiliary factors essential for DSB formation. This finding suggests that FUS/TLS is a component of the protein complex that promotes the initiation of meiotic recombination. Accordingly, we document that FUS/TLS coimmunoprecipitates with SPO11 in vitro and in vivo. The interaction occurs with both SPO11β and SPO11α splice isoforms, which are believed to play distinct functions in the formation of DSBs in autosomes and male sex chromosomes, respectively. Finally, using chromatin immunoprecipitation experiments, we show that FUS/TLS is localized at H3K4me3-marked hotspots in autosomes and in the pseudo-autosomal region, the site of genetic exchange between the XY chromosomes.
Coupling of iron and dissolved organic matter in lakes–selective retention of different size fractions
Authors: Riise Gunnhild , Haaland Ståle Leif , Xiao Yihua 
Published: March 2023

AbstractIncreasing concentration of iron (Fe) is observed in many boreal lakes, such as for the present study in Oslo Østmark, SE-Norway (1983–2018). As Fe-regulating processes are complex and dynamic, the link between mobilizing and retention processes is still not well understood. A seasonal study (2017–2018) from two headwaters, with medium and high dissolved organic matter (DOM) concentrations, showed that the loading of Fe to the lakes was highly dependent on flow conditions. Significantly higher values of Fe were related to autumn and winter periods with high runoff of highly colored and aromatic DOM compared to a severe drought period with minimum Fe values in the lakes. Compared to DOM, a significantly larger part of Fe was in a colloidal form, and a size-selective process (dependent on flow and water retention time) seemed to preferentially settle Fe compared to DOM. In contrast to Fe, the variability in DOM concentrations was moderate through the whole year. However, there were significant changes in the spectroscopic properties of DOM, with decreased fluorescence intensity and increased spectral slope during the warm dry season, indicating increased importance of DOM turnover in the lake. As Fe was transported from the catchment during high flow condition, at the same time as the oxic form of sulfur (SO42−), there was no sign of retention of Fe as FeS. We conclude that the mobilization and retention of compounds that are mainly in a colloidal form, such as Fe, are especially vulnerable to changes in flow conditions, suggesting increased variation in Fe levels in a future climate with increased frequency of flooding and drought episodes.
The maximal regularity property of abstract integrodifferential equations
Authors: Król Sebastian 
Published: March 2023

AbstractWe provide a convenient framework for the study of the well-posedness of a variety of abstract (integro)differential equations in general Banach function spaces. It allows us to extend and complement the known theory on the maximal regularity of such equations. More precisely, by methods of harmonic analysis, we identify large classes of Banach spaces which are invariant with respect to distributional Fourier multipliers. Such classes include general vector-valued Banach function spaces $$\varPhi $$
Φ
and/or the scales of Besov and Triebel–Lizorkin spaces defined by $$\varPhi $$
Φ
. We apply this result to the study of the well-posedness and maximal regularity property of abstract second-order integrodifferential equations, which model various types of elliptic and parabolic problems arising in different areas of applied mathematics.
Double bubble plumbings and two-curve flops
Authors: Smith Ivan , Wemyss Michael 
Published: March 2023

AbstractWe discuss the symplectic topology of the Stein manifolds obtained by plumbing two 3-dimensional spheres along a circle. These spaces are related, at a derived level and working in a characteristic determined by the specific geometry, to local threefolds which contain two floppable$$(-1,-1)$$(-1,-1)-curves meeting at a point. Using contraction algebras we classify spherical objects on the B-side, and derive topological consequences including a complete description of the homology classes realised by graded exact Lagrangians.
Preciseness of artificial intelligence for lateral cephalometric measurements
Authors: El-Dawlatly Mostafa , Attia Khaled Hazem , Abdelghaffar Ahmed Yehia , Mostafa Yehya Ahmed , Abd El-Ghafour Mohamed 
Published: March 2023

Abstract
Background
The aim of the study was to assess the accuracy and efficiency of a new artificial intelligence (AI) method in performing lateral cephalometric radiographic measurements.

Materials and methods
A total of 200 lateral cephalometric radiographs were assessed for quality and included. Three methods were used to perform the cephalometric measurements: (1) the AI method using WebCeph software (AssembleCircle Corp., Gyeonggi-do, Republic of Korea), (2) the modified AI method using WebCeph software after manual modification of the landmarks’ position, and (3) using OnyxCeph software (Image Instruments GmbH, Chemnitz, Germany) by manual landmark identification and digital measurements generation. The results of the measurements produced by the three methods were compared, in addition to comparing the time required for the measurements’ generation required for each method.

Results
Statistically significant differences were detected between the measurements resulting from the three used methods. Fewer differences were detected between the modified AI method and the OnyxCeph method. The AI method produced the measurements the fastest followed by the modified AI method and then the OnyxCeph method.

Conclusions
Considering the used AI software, AI followed by manual tuning of the landmarks’ position might be an accurate method in lateral cephalometric analysis. AI alone is still not fully reliable at locating the different landmarks on the lateral cephalometric radiographs.
Spectrum of Complications and Complication Rates After Diagnostic Catheter Angiography in Neuroradiology
Authors: Tafelmeier Svenja , Kesseler Elisabeth , Iancu Anca-Maria , Nikoubashman Omid , Wiesmann Martin 
Published: March 2023

Abstract
Purpose
To retrospectively evaluate the total complication rates and type of complications after diagnostic cerebral and spinal catheter angiography.

Methods
Data from 2340 patients undergoing diagnostic angiography over a period of 10 years in a neuroradiologic center were retrospectively evaluated. Local, systemic, neurological, and technical complications were analyzed.

Results
A total of 75 clinically noted complications occurred. The risk for clinical complications was increased when the angiography was performed under emergency conditions (p = 0.009). The most common complication was groin hematoma (1.32%). Neurological complications occurred in 0.68% of patients, of which 0.13% were stroke with permanent disability. Technical complications without noticeable clinical symptoms of the patients occurred in 2.35% of the angiographic procedures. Deaths caused by angiography did not occur.

Conclusion
There is a definite risk for complications after diagnostic angiography. Although a very broad spectrum of complications was considered, complications in the individual subgroups showed a low incidence.
Mortality after radiotherapy or surgery in the treatment of early-stage non-small-cell lung cancer: a population-based data analysis in the clinical cancer registry of Brandenburg-Berlin
Authors: Müller Jörg Andreas , Vordermark Dirk , Medenwald Daniel 
Published: March 2023

Abstract
Purpose
Stereotactic body radiotherapy (SBRT) is an established treatment method with favorable toxicity for inoperable early-stage non-small-cell lung cancer (NSCLC) patients. This paper aims to evaluate the importance of SBRT in the treatment of early-stage lung cancer patients compared to surgery as standard of care.

Methods
The German clinical cancer register of Berlin-Brandenburg was assessed. Cases of lung cancer were considered if they had a TNM stage (clinical or pathological) of T1-T2a and N0/x and M0/x, corresponding to UICC stages I and II. In our analyses, cases diagnosed between 2000 and 2015 were included. We adjusted our models with propensity score matching. We compared patients treated with SBRT or surgery regarding age, Karnofsky performance status (KPS), sex, histological grade, and TNM classification. Further, we assessed the association of cancer-related parameters with mortality; hazard ratios (HR) from Cox proportional hazards models were computed.

Results
A total of 558 patients with UICC stages I and II NSCLC were analyzed. In univariate survival models, we found similar survival rates in patients who underwent radiotherapy compared with surgery (HR 1.2, 95% confidence interval [CI] 0.92–1.56; p = 0.2). Our univariate subgroup analyses of patients > 75 years showed a statistically nonsignificant survival benefit for patients treated with SBRT (HR 0.86, 95% CI 0.54–1.35; p = 0.5). Likewise, in our T1 subanalysis, survival rates were similar between the two treatment groups regarding overall survival (HR 1.12, 95% CI 0.57–2.19; p = 0.7). The availability of histological data might be slightly beneficial in terms of survival (HR 0.89, 95% CI 0.68–1.15; p = 0.4). This effect was also not significant. Regarding the availability of histological status in our subgroup analyses of elderly patients, we could show similar survival rates as well (HR 0.70, 95% CI 0.44–1.23; p = 0.14). T1-staged patients also had a statistically nonsignificant survival benefit if histological grading was available (HR 0.75, 95% CI 0.39–1.44; p = 0.4). Concerning adjusted covariates, better KPS scores were associated with better survival in our matched univariate Cox regression models. Further, higher histological grades and TNM stages were related to a higher mortality risk.

Conclusion
Using population-based data, we observed an almost equal survival of patients treated with SBRT compared to surgery in stage I and II lung cancer. The availability of histological status might not be decisive in treatment planning. SBRT is comparable to surgery in terms of survival.
Recognizing cisplatin as a potential radiation recall trigger: case report and focused systematic review
Authors: Tamaskovics Bálint , Haussmann Jan , Karimi Kimia , Daum-Marzian Michael , Gerber Peter Arne , Knapp Felix , Scheckenbach Kathrin , Bölke Edwin , Matuschek Christiane , Budach Wilfried 
Published: March 2023

AbstractWe present a case of mild radiation recall dermatitis triggered by cisplatin chemotherapy given simultaneously to re-irradiation. The dermatitis area correlated to skin exposure of the previous radiation therapy, characterizing the reaction clearly as a recall. Cisplatin has not yet been recognized as a potential trigger for recall reactions. Although it was part of several reported multidrug trigger combinations, all review works referred to cisplatin as not suspicious, suggesting the combination partner as the effector. We performed a focused systematic literature review aiming to re-evaluate the real role of cisplatin as a (co-)triggering factor. In total, 30 reported cases were found, 90% triggered by multidrug combinations. The latter tended to cause more severe symptoms. Besides findings supporting the 20 Gy-threshold theory, no correlation between radiation dose and severity or prevalence was found. Recognition of cisplatin as a trigger of the recall phenomenon and its supportive management may prevent unnecessary cessation of systemic chemotherapy. Systematic reporting of recall events as a secondary endpoint of prospective clinical trials applying radiation therapy could support understanding the recall phenomenon.
Time to surgery after proximal femur fracture in geriatric patients depends on hospital size and provided level of care: analysis of the Registry for Geriatric Trauma (ATR-DGU)
Authors: Gleich Johannes , Neuerburg Carl , Schoeneberg Carsten , Knobe Matthias , Böcker Wolfgang , Rascher Katherine , Fleischhacker Evi ,   Working Committee on Geriatric Trauma Registry of the German Trauma Society (DGU), Berlin, Germany
Published: March 2023

Abstract
Purpose
Proximal femur fractures predominantly affect older patients and can mark a drastic turning point in their lives. To avoid complications and reduce mortality, expert associations recommend surgical treatment within 24–48 h after admission. Due to the high incidence, treatment is provided at a wide range of hospitals with different size and level of care, which may affect time to surgery.

Methods
Data from 19,712 patients included from 2016 to 2019 in the Registry for Geriatric Trauma (ATR-DGU) were analyzed in terms of time to surgery, in-house mortality, mobilization on the first postoperative day, ambulation status on the 7th day after surgery, and initiation of osteoporosis therapy. Participating hospitals were grouped according to their classification as level I, II or III trauma centers. Also presence of additional injuries, intake and type of anticoagulants were considered. Linear and logistic regression analysis was performed to evaluate the influence of hospitals level of care on each item.

Results
28.6% of patients were treated in level I, 37.7% in level II, and 33.7% in level III trauma centers. There was no significant difference in age, sex and ASA-score. Mean time to surgery was 19.2 h (IQR 9.0–29.8) in level I trauma centers and 16.8 h (IQR 6.5–24) in level II/III trauma centers (p < 0.001). Surgery in the first 24 h after admission was provided for 64.7% of level I and 75.0% of level II/III patients (p < 0.001). Treatment in hospitals with higher level of care and subsequent increased time to surgery showed no significant influence on in-house mortality (OR 0.90, 95%-CI 0.78–1.04), but negative effects on walking ability 7 days after surgery could be observed (OR 1.28, 95%-CI 1.18–1.38).

Conclusion
In hospitals of larger size and higher level of care the time to surgery for patients with a proximal femur fracture was significantly higher than in smaller hospitals. No negative effects regarding in-house mortality, but for ambulation status during in-hospital stay could be observed. As the number of these patients will constantly increase, specific treatment capacities should be established regardless of the hospitals size.
Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Authors: Rudman Najda , Kaur Simranjeet , Simunović Vesna , Kifer Domagoj , Šoić Dinko , Keser Toma , Štambuk Tamara , Klarić Lucija , Pociot Flemming , Morahan Grant , Gornik Olga 
Published: March 2023

Abstract
Aims/hypothesis
We previously demonstrated that N-glycosylation of plasma proteins and IgGs is different in children with recent-onset type 1 diabetes compared with their healthy siblings. To search for genetic variants contributing to these changes, we undertook a genetic association study of the plasma protein and IgG N-glycome in type 1 diabetes.

Methods
A total of 1105 recent-onset type 1 diabetes patients from the Danish Registry of Childhood and Adolescent Diabetes were genotyped at 183,546 genetic markers, testing these for genetic association with variable levels of 24 IgG and 39 plasma protein N-glycan traits. In the follow-up study, significant associations were validated in 455 samples.

Results
This study confirmed previously known plasma protein and/or IgG N-glycosylation loci (candidate genes MGAT3, MGAT5 and ST6GAL1, encoding beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase, alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase and ST6 beta-galactoside alpha-2,6-sialyltransferase 1 gene, respectively) and identified novel associations that were not previously reported for the general European population. First, novel genetic associations of IgG-bound glycans were found with SNPs on chromosome 22 residing in two genomic intervals close to candidate gene MGAT3; these include core fucosylated digalactosylated disialylated IgG N-glycan with bisecting N-acetylglucosamine (GlcNAc) (pdiscovery=7.65 × 10−12, preplication=8.33 × 10−6 for the top associated SNP rs5757680) and core fucosylated digalactosylated glycan with bisecting GlcNAc (pdiscovery=2.88 × 10−10, preplication=3.03 × 10−3 for the top associated SNP rs137702). The most significant genetic associations of IgG-bound glycans were those with MGAT3. Second, two SNPs in high linkage disequilibrium (missense rs1047286 and synonymous rs2230203) located on chromosome 19 within the protein coding region of the complement C3 gene (C3) showed association with the oligomannose plasma protein N-glycan (pdiscovery=2.43 × 10−11, preplication=8.66 × 10−4 for the top associated SNP rs1047286).

Conclusions/interpretation
This study identified novel genetic associations driving the distinct N-glycosylation of plasma proteins and IgGs identified previously at type 1 diabetes onset. Our results highlight the importance of further exploring the potential role of N-glycosylation and its influence on complement activation and type 1 diabetes susceptibility.

Graphical abstract
Sex differences in type 2 diabetes
Authors: Kautzky-Willer Alexandra , Leutner Michael , Harreiter Jürgen 
Published: March 2023

AbstractThe prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually diagnosed at a younger age and lower body fat mass than women. Worldwide, an estimated 17.7 million more men than women have diabetes mellitus. Women appear to bear a greater risk factor burden at the time of their type 2 diabetes diagnosis, especially obesity. Moreover, psychosocial stress might play a more prominent role in diabetes risk in women. Across their lifespan, women experience greater hormone fluctuations and body changes due to reproductive factors than men. Pregnancies can unmask pre-existing metabolic abnormalities, resulting in the diagnosis of gestational diabetes, which appears to be the most prominent risk factor for progression to type 2 diabetes in women. Additionally, menopause increases women’s cardiometabolic risk profile. Due to the progressive rise in obesity, there is a global increase in women with pregestational type 2 diabetes, often with inadequate preconceptual care. There are differences between men and women regarding type 2 diabetes and other cardiovascular risk factors with respect to comorbidities, the manifestation of complications and the initiation of and adherence to therapy. Women with type 2 diabetes show greater relative risk of CVD and mortality than men. Moreover, young women with type 2 diabetes are currently less likely than men to receive the treatment and CVD risk reduction recommended by guidelines. Current medical recommendations do not provide information on sex-specific or gender-sensitive prevention strategies and management. Thus, more research on sex differences, including the underlying mechanisms, is necessary to increase the evidence in the future. Nonetheless, intensified efforts to screen for glucose metabolism disorders and other cardiovascular risk factors, as well as the early establishment of prophylactic measures and aggressive risk management strategies, are still required for both men and women at increased risk of type 2 diabetes. In this narrative review we aim to summarise sex-specific clinical features and differences between women and men with type 2 diabetes into risk factors, screening, diagnosis, complications and treatment.
Graphical abstract
Estimated impact of the COVID-19 pandemic on the prevalence and treatment of depressive symptoms in Peru: an interrupted time series analysis in 2014–2021
Authors: Villarreal-Zegarra David , Reátegui-Rivera C. Mahony , Otazú-Alfaro Sharlyn , Yantas-Alcantara Gloria , Soto-Becerra Percy , Melendez-Torres G. J. 
Published: March 2023

Abstract
Purpose
The COVID-19 pandemic increased the burden of mental disorders worldwide. Peru has been one of the countries most affected by COVID-19, however, studies evaluating the medium and long-term consequences of the pandemic on Peruvians’ mental health are recent and represent a new field of study in proliferation. We aimed to estimate the impact of the COVID-19 pandemic on the prevalence and treatment of depressive symptoms using nationally representative surveys in Peru.

Methods
Our study is an analysis of secondary data. We carried out a time series cross-sectional analysis based on the National Demographic and Health Survey of Peru, collected using a complex sampling design. The Patient Health Questionnaire-9 was used to measure mild (5–9 points), moderate (10–14 points), and severe (15 points or more) depressive symptoms. The participants were men and women aged 15 years and older, living in urban and rural areas of all regions of Peru. The main statistical analysis used segmented regression with Newey-West standard errors, taking into account that each year of the evaluation was divided into four measures (quarter measure).

Results
We included 259,516 participants. An average quarterly increase of 0.17% (95% CI 0.03–0.32%) in the prevalence of moderate depressive symptoms was identified after the onset of the COVID-19 pandemic (approximately an increase of 1583 new cases of moderate depressive symptoms by each quarter). The percentage of cases treated for mild depressive symptoms increased quarterly by an average of 0.46% (95% CI 0.20–0.71%) after the onset of the COVID-19 pandemic (approximately an increase of 1242 new cases treated for mild depressive symptoms by each quarter).

Conclusion
In Peru, increases in the prevalence of moderate depressive symptoms and the proportion of cases treated with mild depressive symptoms were found after the COVID-19 pandemic. Therefore, this study is a precedent for future research assessing the prevalence of depressive symptoms and the proportion of cases receiving treatment during the pandemic and post-pandemic years.