bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms
Authors: Yi You , Zhong Chen , Wei-wei Hu 
Published: May 2023

Febrile seizures (FSs) are convulsions caused by a sudden increase in body temperature during a fever. FSs are one of the commonest presentations in young children, occurring in up to 4% of children between the ages of about 6 months and 5 years old. FSs not only endanger children’s health, cause panic and anxiety to families, but also have many adverse consequences. Both clinical and animal studies show that FSs have detrimental effects on neurodevelopment, that cause attention deficit hyperactivity disorder (ADHD), increased susceptibility to epilepsy, hippocampal sclerosis and cognitive decline during adulthood. However, the mechanisms of FSs in developmental abnormalities and disease occurrence during adulthood have not been determined. This article provides an overview of the association of FSs with neurodevelopmental outcomes, outlining both the underlying mechanisms and the possible appropriate clinical biomarkers, from histological changes to cellular molecular mechanisms. The hippocampus is the brain region most significantly altered after FSs, but the motor cortex and subcortical white matter may also be involved in the development disorders induced by FSs. The occurrence of multiple diseases after FSs may share common mechanisms, and the long-term role of inflammation and γ-aminobutyric acid (GABA) system are currently well studied.
Economic analysis of remote monitoring in patients with implantable cardioverter defibrillators or cardiac resynchronization therapy defibrillators in the Trento area, Italy
Authors: Marini Massimiliano , Videsott Lodovica , Dalle Fratte Chiara Francesca , Francesconi Andrea , Bonvicini Eleonora , Quintarelli Silvia , Martin Marta , Guarracini Fabrizio , Coser Alessio , Benetollo Pier Paolo , Bonmassari Roberto , Boriani Giuseppe 
Published: May 2023

IntroductionRemote monitoring (RM) technologies have the potential to improve patient care by increasing compliance, providing early indications of heart failure (HF), and potentially allowing for therapy optimization to prevent HF admissions. The aim of this retrospective study was to assess the clinical and economic consequences of RM vs. standard monitoring (SM) through in-office cardiology visits, in patients carrying a cardiac implantable electronic device (CIED).MethodsClinical and resource consumption data were extracted from the Electrophysiology Registry of the Trento Cardiology Unit, which has been systemically collecting patient information from January 2011 to February 2022. From a clinical standpoint, survival analysis was conducted, and incidence of cardiovascular (CV) related hospitalizations was measured. From an economic standpoint, direct costs of RM and SM were collected to compare the cost per treated patient over a 2-year time horizon. Propensity score matching (PSM) was used to reduce the effect of confounding biases and the unbalance of patient characteristics at baseline.ResultsIn the enrollment period, N = 402 CIED patients met the inclusion criteria and were included in the analysis (N = 189 patients followed through SM; N = 213 patients followed through RM). After PSM, comparison was limited to N = 191 patients in each arm. After 2-years follow-up since CIED implantation, mortality rate for any cause was 1.6% in the RM group and 19.9% in the SM group (log-rank test, p &lt; 0.0001). Also, a lower proportion of patients in the RM group (25.1%) were hospitalized for CV-related reasons, compared to the SM group (51.3%; p &lt; 0.0001, two-sample test for proportions). Overall, the implementation of the RM program in the Trento territory was cost-saving in both payer and hospital perspectives. The investment required to fund RM (a fee for service in the payer perspective, and staffing costs for hospitals), was more than offset by the lower rate of hospitalizations for CV-related disease. RM adoption generated savings of −€4,771 and −€6,752 per patient in 2 years, in the payer and hospital perspective, respectively.ConclusionRM of patients carrying CIED improves short-term (2-years) morbidity and mortality risks, compared to SM and reduces direct management costs for both hospitals and healthcare services.
The first discovery of amber resin in Lichi Mélange, Eastern Taiwan
Authors: Pang Chi-Hsiu , Yang Tzu-Ruei , Chang Ying-Ju , Lin Shu-Hong , Shiau Liang-Jian , Chen Chih-Tung , Chang Chung-Pai , Lo Li 
Published: May 2023

Amber is fossilized tree resin produced by the metabolism of vascular plants that has experienced various geological processes, including burial, compression, and heating. Therefore, most of the previously reported amber pieces were unearthed from sedimentary rocks. The record of amber in tectonic active regions, e.g., Taiwan, is extremely poor and has not been scientifically certified, leading to a poor understanding of the history of prehistoric flora in this region. This study reports a 1-cm yellow-brown amorphous resin interspersed in sandstone blocks in the Lichi Mélange at the southernmost tip of the Coastal Range in eastern Taiwan, representing the first official record of amber from the mélange unit and as well as in Taiwan. The results, in addition to the affirmation of the amber, show that the amber is composed of sesquiterpenes and triterpenoids, indicating a possible origin of dipterocarp trees that are absent in the paleobotanic record and modern flora in Taiwan. Furthermore, infrared spectra analysis shows its compositional similarity to the amber from Sumatra, Indonesia, which boasts modern dipterocarp forests. Petrographic analysis of the surrounding sandstone suggests that the amber was deposited into the continental margin and allocated to Taiwan through the arc-continental collision in ∼6–7 Ma. In summary, this study represents the first report of amber unearthed in the mélange unit and Taiwan. It shows that amber is a durable and reliable information carrier in accordance with biogeographic and tectonic evidence.
Equipping future teachers with innovative strategies that increase physical activity in the classroom: a hybrid implementation trial across three Australian universities
Authors: Lander Natalie J. , Mazzoli Emiliano , Essiet Inimfon A. , Telford Amanda , Ridley Kate , Symington Naomi , Salmon Jo 
Published: May 2023

IntroductionTransformEd targets initial teacher education (ITE) to equip future teachers with innovative strategies that increase physical activity in the Primary school classroom.MethodsThis hybrid implementation-effectiveness trial investigated the effects of the TransformEd program when embedded in ITE degrees at two Australian universities (University 1 Single Unit offering; University 2 Dual Unit offering) over a 12-week period, on pre-service teachers’ perceived competence, confidence, and willingness to deliver active pedagogies, in comparison with a third ‘usual practice’ control university.ResultsThere was a favourable intervention effect on the total teacher perceptions score among pre-service teachers in University 1 compared to the control group pre-service teachers. Further, there was a significant intervention effect on reduced perceived barriers to active strategies in University 1, and a significant increase in perceived effects of active strategies on Primary school student outcomes in University 2. Qualitative data suggested the program strengthened the connection between theory and practice (i.e., how pre-service teachers are educated in university and the way they teach in Primary schools). The program was motivating to both lecturers and pre-service teachers, resulted in them reflecting on their own teaching practice, and helped with pre-service teacher engagement.DiscussionRecommendations for improvement included stronger and more explicit alignment with the Australian Professional Standards for Teachers.
Study of the quality index of groundwater (GWQI) and its use for irrigation purposes using the techniques of the geographic information system (GIS) of the plain Nekor-Ghiss (Morocco)
Authors: Elkhalki S. , Hamed R. , Jodeh S. , Ghalit M. , Elbarghmi R. , Azzaoui K. , Hanbali G. , Ben Zhir K. , Ait Taleb B. , Zarrouk A. , Lamhamdi A. 
Published: May 2023

Groundwater is an indispensable source of water for drinking water supply, agriculture and industry worldwide. In arid and semi-arid regions, groundwater has seriously deteriorated in recent decades due to environmental changes, anthropogenic activities and marine intrusion. A total of 79 groundwater samples from the Nekor-Ghiss plain were sampled for major chemical ion analysis. These analyzes showed that the water samples were highly mineralized (&gt;1,500 mg/L), with hardness (83.5% of the samples were very hard) and high concentrations of chemical elements, such as Cl−, Mg2+, Na+ and SO42-. To assess the quality of water in the study area for irrigation and consumption purposes, we used the quality index (GWQI) as well as a multi-criteria analysis based on “geographic information system” by assigning a weight to the different water quality parameters. Also, Piper and Durov diagram was investigated. The results of the study were focused on the water quality parameters of the collected groundwater samples, such as the sodium adsorption rate (SAR), the percentage of soluble sodium (Na%), the Residual Sodium Carbonate (RSC) and Permeability Index (PI) Majority of water samples in the study area are suitable to be used for irrigation. Magnesium Risk (MH) and Kelley’s Ratio Kelly ratio. 51.9% unsuitable samples to 59.49% good samples for irrigation purposes. Monitoring the quality and quantity of groundwater is crucial for the effective and sustainable management of this valuable resource. According to the results obtained, it appears that 92% of all the samples are located in the domain of frequent recharge waters of limestone and dolomitic aquifers, namely, Ca-Mg-HCO3. About 8% of the samples measured have a composition of the Ca-Na-Mg-HCO3 type.
Magnifier or refractor? Exploring the impact of geographical indication on people’s perception of the value of cultural ecosystem services based on the SolVES model
Authors: Luo Youyu , Xu Huilin , Zhang Junjie , Chen Nan , Ye Haiyan , Lei Wenyan 
Published: May 2023

Purpose/SignificanceTo a certain extent, geographical indication (GI) protects the ecosystem of product origin, but there is still a lack of quantitative evidence on its cultural spillover effect. The mechanism of the impact of geo-certified landscapes on people’s perceived value of cultural ecosystem services (CESs) should be explored.Methods/ProceduresIn this study, two urban forest parks, Changqing and Zhongshan, which differ mainly in terms of geo-certified landscapes, were selected in Beihai, Guangxi. Basically, homogeneous volunteers were recruited, and photos of value labels were collected from their independent visits to two parks. The SolVES model was used to explore the effect of the presence or absence of geo-certified landscapes in urban park ecosystems on people’s CESs needs and the relation to the spatial context of the landscape.Results/ConclusionsThe results show that GI significantly enhance people’s perception of human CESs value of landscape elements, and clarifies the correspondence perception relationship between CESs value types and each landscape element. In addition to the spillover effect on humanistic value perception, GI also attracts and transfers people’s esthetic attention to the natural landscape itself to a certain extent. And these two effects will also spread to the ecosystem that the landscape belongs to.
The overexpression of actin related protein 2/3 complex subunit 1B(ARPC1B) promotes the ovarian cancer progression via activation of the Wnt/β-catenin signaling pathway
Authors: Huang Junning , Zhou Haiqin , Tan Caichun , Mo Shien , Liu Tingji , Kuang Yan 
Published: May 2023

IntroductionOvarian cancer is one of the most fatal malignancies of the female reproductive system. The purpose of this study is to explore the mechanism of Actin Related Protein 2/3 Complex Subunit 1B(ARPC1B) in the progression of ovarian cancer.MethodsThe expressions and prognostic value of ARPC1B in ovarian cancer were identified using the GEPIA database and the Kaplan-Meier Plotter database. The expression of ARPC1B was manipulated to evaluate its impact on the malignant phenotypes of ovarian cancer. The cell proliferation ability was analyzed through CCK-8 assay and clone formation assay. The cell migration and invasion capacity was evaluated through wound healing assay and trans well assay. Mice xenografts were conducted to measure the effects of ARPC1B on tumor development in vivo.ResultsOur data suggested that ARPC1B was overexpressed in ovarian cancer, which was correlated with a poorer survival compared to low mRNA expression of ARPC1B in ovarian cancer patients. The overexpression of ARPC1B promoted cell proliferation, migration, and invasion of ovarian cancer cells. Conversely, the knockdown of ARPC1B resulted in the opposite effect. Additionally, ARPC1B expression could activate Wnt/β-catenin signaling pathway. The administration of the β-catenin inhibitor XAV-939 abolished the promotion of cell proliferation, migration, and invasion activities induced by ARPC1B overexpression in vitro.ConclusionsARPC1B was overexpressed in ovarian cancer and was correlated with poor prognosis. ARPC1B promoted ovarian cancer progression through activation of Wnt/β-catenin Signaling Pathway.
Prediction of mortality in pneumonia patients with connective tissue disease treated with glucocorticoids or/and immunosuppressants by machine learning
Authors: Li Dongdong , Ding Liting , Luo Jiao , Li Qiu-Gen 
Published: May 2023

ObjectivesThe assessment of accurate mortality risk is essential for managing pneumonia patients with connective tissue disease (CTD) treated with glucocorticoids or/and immunosuppressants. This study aimed to construct a nomogram for predicting 90-day mortality in pneumonia patients using machine learning.MethodsData were obtained from the DRYAD database. Pneumonia patients with CTD were screened. The samples were randomly divided into a training cohort (70%) and a validation cohort (30%). A univariate Cox regression analysis was used to screen for prognostic variables in the training cohort. Prognostic variables were entered into the least absolute shrinkage and selection operator (Lasso) and a random survival forest (RSF) analysis was used to screen important prognostic variables. The overlapping prognostic variables of the two algorithms were entered into the stepwise Cox regression analysis to screen the main prognostic variables and construct a model. Model predictive power was assessed using the C-index, the calibration curve, and the clinical subgroup analysis (age, gender, interstitial lung disease, diabetes mellitus). The clinical benefits of the model were assessed using a decision curve analysis (DCA). Similarly, the C-index was calculated and the calibration curve was plotted to verify the model stability in the validation cohort.ResultsA total of 368 pneumonia patients with CTD (training cohort: 247; validation cohort: 121) treated with glucocorticoids or/and immunosuppressants were included. The univariate Cox regression analysis obtained 19 prognostic variables. Lasso and RSF algorithms obtained eight overlapping variables. The overlapping variables were entered into a stepwise Cox regression to obtain five variables (fever, cyanosis, blood urea nitrogen, ganciclovir treatment, and anti-pseudomonas treatment), and a prognostic model was constructed based on the five variables. The C-index of the construction nomogram of the training cohort was 0.808. The calibration curve, DCA results, and clinical subgroup analysis showed that the model also had good predictive power. Similarly, the C-index of the model in the validation cohort was 0.762 and the calibration curve had good predictive value.ConclusionIn this study, the nomogram developed performed well in predicting the 90-day risk of death in pneumonia patients with CTD treated with glucocorticoids or/and immunosuppressants.
Early feeding leads to molecular maturation of the gut mucosal immune system in suckling piglets
Authors: Choudhury Raka , Gu Yuner , Bolhuis J. Elizabeth , Kleerebezem Michiel 
Published: May 2023

IntroductionDiet-microbiota-host interactions are increasingly studied to comprehend their implications in host metabolism and overall health. Keeping in mind the importance of early life programming in shaping intestinal mucosal development, the pre-weaning period can be utilised to understand these interactions in suckling piglets. The objective of this study was to investigate the consequences of early life feeding on the time-resolved mucosal transcriptional program as well as mucosal morphology.MethodsA customised fibrous feed was provided to piglets (early-fed or EF group; 7 litters) from five days of age until weaning (29 days of age) in addition to sow’s milk, whereas control piglets (CON; 6 litters) suckled mother’s milk only. Rectal swabs, intestinal content, and mucosal tissues (jejunum, colon) were obtained pre- and post-weaning for microbiota analysis (16S amplicon sequencing) and host transcriptome analysis (RNA sequencing).ResultsEarly feeding accelerated both microbiota colonisation as well as host transcriptome, towards a more “mature state”, with a more pronounced response in colon compared to jejunum. Early feeding elicited the largest impact on the colon transcriptome just before weaning (compared to post-weaning time-points), exemplified by the modulation of genes involved in cholesterol and energy metabolism and immune response. The transcriptional impact of early feeding persisted during the first days post-weaning and was highlighted by a stronger mucosal response to the weaning stress, via pronounced activation of barrier repair reactions, which is a combination of immune activation, epithelial migration and “wound-repair” like processes, compared to the CON piglets.DiscussionOur study demonstrates the potential of early life nutrition in neonatal piglets as a means to support their intestinal development during the suckling period, and to improve adaptation during the weaning transition.
Testing indicators for trend assessment of range and habitat of low-density cetacean species in the Mediterranean Sea
Authors: Arcangeli Antonella , Atzori Fabrizio , Azzolin Marta , Babey Lucy , Campana Ilaria , Carosso Lara , Crosti Roberto , Garcia-Garin Odei , Gregorietti Martina , Orasi Arianna , Scuderi Alessia , Tepsich Paola , Vighi Morgana , David Léa 
Published: May 2023

IntroductionConservation of cetaceans is challenging due to their large-range, highly-dynamic nature. The EU Habitats Directive (HD) reports 78% of species in ‘unknown’ conservation status, and information on low-density/elusive species such G.griseus, G.melas, Z.cavirostris is the most scattered.MethodsThe FLT-Net programme has regularly collected year-round data along trans-border fixed-transects in the Mediterranean Sea since 2007. Nearly 7,500 cetacean sightings were recorded over 500,000 km of effort with 296 of less-common species. Comparing data across two HD 6-years periods (2013-2019/2008-2012), this study aimed at testing four potential indicators to assess range and habitat short-term trends of G.griseus, G.melas, Z.cavirostris: 1) change in Observed Distributional Range-ODR based on known occurrence, calculated through the Kernel smoother within the effort area; 2) change in Ecological Potential Range-EPR extent, predicted through Spatial Distribution Models; 3) Range Pattern, assessed as overlap and shift of core areas between periods; 4) changes in ODR vs EPR.ResultsMost ODR and EPR confirmed the persistence of known important sites, especially in the Western-Mediterranean. All species, however, exhibit changes in the distribution extent (contraction or expansion) and an offshore shift, possibly indicating exploitation of new areas or avoidance of more impacted ones.DiscussionResults confirmed that the ODR could underestimate the real occupied range, as referring to the effort area only; it can be used to detect trends providing that the spatio-temporal effort scale is representative of species range. The EPR allows generalising species distribution outside the effort area, defining species’ Habitat and the Occupied/Potential Range proportion. To investigate range-trends, EPR needs to be adjusted based also on the Occupied/Potential Range proportion since it could be larger than the occupied range in presence of limiting factors, or smaller, if anthropogenic pressures force the species outside the ecological niche.ConclusionUsing complementary indicators proved valuable to evaluate the significance of changes. The concurrent analysis of more species with similar ecology was also critical to assess whether the detected changes are species-specific or representative of broader trends. The FLT-Net sampling strategy proved adequate for trend assessment in the Western-Mediterranean and Adriatic basins, while more transects are needed to characterize the Central-Mediterranean and Aegean-Levantine ecological variability.
Observation of linear magnetoelectric effect in a Dirac magnon antiferromagnet Cu3TeO6
Authors: Shahee Aga , Yoo Kyongjun , Koteswararao B. , Ter-Oganessian N. V. , Kim Kee Hoon 
Published: May 2023

Cu3TeO6, a three-dimensional antiferromagnet forming a unique spin-web lattice of spin-1/2 Cu2+ ions below the Néel temperature TN ≈ 62 K, has recently been found to exhibit topological Dirac or nodal magnon dispersion. In this study, we report the discovery of the linear magnetoelectric (ME) effects in Cu3TeO6 below TN. Our pyroelectric current measurements at a constant magnetic field (H) reveal a linear increase of electric polarization (P) with H for both P//H and P⊥ H configurations; a maximum P//[110] = 20 µC/m2 is obtained at µ0H//11¯0 = 14 T, corresponding to a linear ME coefficient 1.8 ps/m. Magnetic point group analysis and Monte-Carlo simulations confirm that finite linear ME coefficients are allowed in the off-diagonal and diagonal ME tensor components, consistent with the magnetic point group of 3¯′. As the parity-time symmetry can be broken in the presence of H or electric field E in the linear ME materials, we envisage that Cu3TeO6 should exhibit a H- or E-induced transformation in the topological magnon dispersion from a Dirac point/nodal line type into two Weyl point types.