bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the use of panoramic radiography add information in the temporomandibular joint evaluation in Juvenile Idiopathic Arthritis patients? A case control study
Authors: Rosa Vera Lucia Mestre , Zwir Liete M. Figueiredo , Dutra Marcelo Eduardo Pereira , Russo Gleice Clemente Souza , Rodrigues Wellington Douglas R. , Terreri Maria Teresa 
Published: February 2023

Abstract
Objective
To determine the frequency of radiographic changes in the temporomandibular joint, in a representative population of patients with Juvenile Idiopathic Arthritis (JIA) and to compare with findings in healthy controls matched by sex and age.

Patients and Methods
One hundred and thirty-seven panoramic radiographies (PR) from JIA patients of a pediatric rheumatology outpatient clinic were prospectively evaluated and compared to 137 PR from healthy individuals.

Results
102 (74.5%) JIA patients and 47 (34.3%) controls showed at least one radiological alteration (p < 0.001). The following radiographic alterations were more frequently observed in JIA patients than in controls: erosion (p < 0.001), altered condylar morphology (p < 0.001), disproportion between condylar process and the coronoid process (p < 0.001) and accentuated curve in the antegonial notch (p = 0.002). Twenty patients (14.6%) presented the four radiographic alterations simultaneously compared to only two controls (1.5%) (p < 0.001).

Conclusion
Due to the difference in the frequency of findings in the PR of patients and controls, we concluded that PR has value as a screening tool. In the presence of major changes in the mandible head in the PR of patients with a confirmed diagnosis of JIA, MRI should be considered to detect an active inflammatory process in this joint.
Effects of dietary supplementation with prebiotics and Pediococcus acidilactici on gut health, transcriptome, microbiota, and metabolome in Atlantic salmon (Salmo salar L.) after seawater transfer
Authors: Dhanasiri Anusha K. S. , Jaramillo-Torres Alexander , Chikwati Elvis M. , Forberg Torunn , Krogdahl Åshild , Kortner Trond M. 
Published: February 2023

Abstract
Background
Given the importance of gut microbiota for health, growth and performance of the host, the aquaculture industry has taken measures to develop functional fish feeds aiming at modulating gut microbiota and inducing the anticipated beneficial effects. However, present understanding of the impact of such functional feeds on the fish is limited. The study reported herein was conducted to gain knowledge on performance and gut health characteristics in post-smolt Atlantic salmon fed diets varying in content of functional ingredients. Three experimental diets, a diet containing fructo-oligosaccharides (FOS), a diet with a combination of FOS and Pediococcus acidilactici (BC) and a diet containing galacto-oligosaccharides (GOS) and BC, were used in a 10-weeks feeding trial. A commercial diet without functional ingredients was also included as a control/reference. Samples of blood plasma, mucosa and digesta were subjected to microbiota, transcriptome and metabolome profiling for evaluation of the diet effects.

Results
No significant growth differences were observed between fish fed the supplemented diets, but FOS–BC fed fish showed significantly faster growth than the control fed fish. The microbiota results showed that the BC was present in both the digesta, and the mucosa samples of fish fed the FOS–BC and GOS–BC diets. Digesta-associated microbiota was altered, while mucosa-associated microbiota was relatively unaffected by diet. Replacing FOS with GOS increased the level of metabolites linked to phospholipid, fatty acid, carnitine and sphingolipid metabolism. Variation in metabolite levels between the treatments closely correlated with genera mainly belonging to Firmicutes and Actinobacteria phyla. The transcriptome analyses indicated diet effects of exchanging FOS with GOS on immune functions, oxidative defense and stress responses. No significant diet effect was observed on intestinal inflammation in the pyloric caeca or in the distal intestine, or on lipid accumulation in the pyloric caeca.

Conclusions
Dietary supplementation with BC induced moderate effects on the microbiota of the digesta, while the effects of replacing FOS with GOS were more marked and was observed also for nutrient metabolism. Our data indicates therefore that the quality of a prebiotic may be of great importance for the effects of a probiotic on gut microbiota, function, and health.
In vitro anticancer activity of hydatid cyst fluid on colon cancer cell line (C26)
Authors: Motavallihaghi Seyedmousa , Tanzadehpanah Hamid , Soleimani Asl Sara , Shojaeian Ali , Yousefimashouf Milad , Barati Nastaran 
Published: February 2023

Abstract
Background
Colon cancer is the third most common cancer and the fourth leading cause of death from cancer. Some parasites are introduced as an antineoplastic agents that can inhibit the progress of some cancers. The aim of this study was to investigate the effect of crude hydatid cyst fluid (HCF) on clone cancer cell line (C26).

Methods
HCF was isolated from hydatid cysts by syringe, and at the first, its toxicity was obtained by 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Cell cycle analysis and apoptosis were measured by flow cytometer, and also the expression of Bcl-2 Associated X-protein (BAX) and B-cell lymphoma-2 (BCL2) genes was measured by quantitative reverse transcription PCR.

Results
The amount of apoptosis was increased in B antigen-treated cell lines in comparison with the control group. Also, the expression of BAX was increased in the treated group, while the BCL2 expression was decreased in comparison with the control one. Cell cycle analysis in the antigen-treated group compared to the other groups showed that the cells were more in the G0/G1 phase, as well as in the G2/M phase, and fewer cells were in the synthesis phase.

Conclusion
Our finding showed that HCF possibly contains active compounds and can limit the growth and development of C26 cell line by reducing or increasing the genes involved in apoptosis and finally the effect on the cell cycle.

Graphical Abstract
Intelligent optoelectronic processor for orbital angular momentum spectrum measurement
Authors: Wang Hao , Zhan Ziyu , Hu Futai , Meng Yuan , Liu Zeqi , Fu Xing , Liu Qiang 
Published: February 2023

AbstractOrbital angular momentum (OAM) detection underpins almost all aspects of vortex beams’ advances such as communication and quantum analogy. Conventional schemes are frustrated by low speed, complicated system, limited detection range. Here, we devise an intelligent processor composed of photonic and electronic neurons for OAM spectrum measurement in a fast, accurate and direct manner. Specifically, optical layers extract invisible topological charge information from incoming light and a shallow electronic layer predicts the exact spectrum. The integration of optical-computing promises us a compact single-shot system with high speed and energy efficiency (optical operations / electronic operations ~$${10}^{3}$$103), neither necessitating reference wave nor repetitive steps. Importantly, our processor is endowed with salient generalization ability and robustness against diverse structured light and adverse effects (mean squared error ~$$10^{(-5)}$$10(-5)). We further raise a universal model interpretation paradigm to reveal the underlying physical mechanisms in the hybrid processor, as distinct from conventional ‘black-box’ networks. Such interpretation algorithm can improve the detection efficiency up to 25-fold. We also complete the theory of optoelectronic network enabling its efficient training. This work not only contributes to the explorations on OAM physics and applications, and also broadly inspires the advanced links between intelligent computing and physical effects.
Efficacy and gastrointestinal tolerability of methotrexate in late-onset rheumatoid arthritis patients: a prospective cohort study
Authors: Bayrak Esra Dilsat , Aktas Ilknur 
Published: February 2023

Abstract

Background
The proportion of the late-onset forms of disease is growing in rheumatoid arthritis (RA) population. Concerns about comorbidities and drug adverse events lead to delay or ineffective treatment in these patients. The aim of this study is to analyze the tolerability and efficacy of methotrexate therapy in late-onset RA (LORA) patients and compare the baseline characteristics, efficacy, and gastrointestinal (GIT) adverse effects of methotrexate treatment between LORA and young-onset RA patients (YORA).

Results
Patients whose symptoms began after 65 years or older were classified as LORA. Baseline characteristics, rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status, C-reactive proten (CRP) levels, disease activity scores, and radiographs of hands and feet were recorded. Patients were started to methotrexate therapy and followed for 6 months. Female gender was predominant in both LORA and YORA. LORA patients had less seropositivity (RF or anti-CCP), higher CRP levels, and higher DAS 28 scores. More than half of the patients (58%) had large joint involvement. Remission rates were higher in LORA patients, and total remission and low disease activity rates were similar. Methotrexate withdrawal due to gastrointestinal adverse events (nausea and vomiting) was lower than YORA patients. Logistic regression analysis demonstrated that DAS 28 score was the only predictor for disease remission (p: 0.000), and no predictive factor was found for methotrexate-related adverse events.

Conclusion
Methotrexate-related gastrointestinal adverse events do not increase in LORA patients, and nausea-vomiting is seen lower than YORA. Methotrexate is well tolerated and effective in LORA patients, and a large amount of patients achieve treatment targets after 6 months of treatment with MTX. Methotrexate should be started immediately in LORA without additional concerns on adverse effects.
Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling
Authors: Winningham Amanda H , Camper Sally A 
Published: February 2023

Abstract
Epithelial to mesenchymal transition (EMT) is important for many developing organs, and for wound healing, fibrosis, and cancer. Pituitary stem cells undergo an EMT-like process as they migrate and initiate differentiation, but little is known about the input of signaling pathways or the genetic hierarchy of the transcriptional cascade. Prop1 mutant stem cells fail to undergo changes in cellular morphology, migration, and transition to the Pou1f1 lineage. We used Prop1 mutant mice to identify the changes in gene expression that are affiliated with EMT-like processes. BMP and TGF-β family gene expression was reduced in Prop1 mutants and Elf5, a transcription factor that characteristically suppresses EMT, had elevated expression. Genes involved in cell-cell contact such as cadherins and claudins were elevated in Prop1 mutants. To establish the genetic hierarchy of control, we manipulated gene expression in pituitary stem cell colonies. We determined that the EMT inducer, Zeb2, is necessary for robust BMP signaling and repression of Elf5. We demonstrated that inhibition of BMP signaling affects expression of target genes in the Id family, but it does not affect expression of other EMT genes. Zeb2 is necessary for expression of the SHH effector gene Gli2. However, knock down of Gli2 has little effect on the EMT-related genes, suggesting that it acts through a separate pathway. Thus, we have established the genetic hierarchy involved in the transition of pituitary stem cells to differentiation.
Ticket to a Museum: Reading Orhan Pamuk in Our Times
Authors: Rajan Rajeswari Sunder 
Published: February 2023

Abstract
This article is an inquiry into the Museum of Innocence in Istanbul, designed and built by the writer Orhan Pamuk as twin to his novel The Museum of Innocence (2008). It is interested in what might lie behind the desire of the contemporary novelist to buttress the world of his novel with the material addition of a museum (a collection of the things depicted in the novel), an artifact also invented by himself. Understanding the circumstances in which the alliance between novel and museum takes place, through Pamuk's explanations but going beyond them—its conditions of possibility, so to speak—provides the larger perspective in which it can be seen in dialectical relation to contemporary literature and culture.
Truth in Autobiography
Authors: Konrád György 
Published: February 2023

Abstract
Originally published in Common Knowledge 11, no. 2 (Fall 2005), this essay is reprinted in 2022 as the prelude to the first installment of a project titled “Antipolitics” and dedicated to the author's memory. “To really know” what a writer “is like,” Konrád writes here, “he would have to look back on his biography from after death” — and in this piece he hauntingly does so. Explaining that he composed his first autobiography upon being expelled from university in Hungary after Stalin's death in 1953, he defines the process as “the main event in the ritual of political detention.” In an overview of the writer's life, he describes any act of writing as like scratching one's initials “into the brick of a prison wall” in an effort “to avoid dying completely.” The editors of Common Knowledge, of whose editorial board Konrád was a founding member, chose to reprint this statement at the head of a symposium whose purpose is, in no small part, to help secure his posthumous existence.
“In the Mountain Forest I Lose My Self”: The Experience of No-Self in Wang Wei's Short Landscape Poems
Authors: Tähtinen Tero 
Published: February 2023

Abstract
This article discusses the dialectics of subject and object in Wang Wei's short landscape poems from the perspective of Buddhist metaphysics. First, the article traces Wang's Buddhist connections and surveys the Buddhist concepts, ideas, and practices of which Wang himself explicitly wrote in his essays and poems. Then it uses these ideas to analyze poems from his “Wang Stream Collection” (Wangchuan ji). The conjunctive theme of this article is the underlying emptiness of all existing phenomena, one of the main metaphysical doctrines of Mahayana philosophy and a recurrent motif in Wang's poetry. The author demonstrates that, when seen from the standpoint of emptiness, the relation of the perceiver and the perceived in Wang's short nature poems proves to be more sophisticated than usually thought. Because both the human agent and the natural objects around him are intrinsically empty, they are interrelated and interdependent in the act of perception at the deepest and the most subtle ontological level.
Reconstructing financial analysis courses in higher vocational education in China: a factor analysis approach
Authors: Yan Weiwei , Sun Pengge 
Published: February 2023

Background: The development of information technology has had a significant impact on traditional financial analysis. For large amounts of data and complex business environments, financial analysts are required to use technical analysis tools to process mass data and deeply integrate financial analysis and enterprise value to enhance the competitiveness of enterprises. This requires the reconstruction of the financial analysis courses in higher vocational education in China. This manuscript studies the problems existing in traditional financial analysis courses and reconstructs these. Methods: A factor analysis approach is adopted to reconstruct the financial analysis courses. We study these courses from three perspectives — coursebooks, teachers, and teaching methods. We collected the data of relevant courses from online platforms in China and used content analysis to find the problems existing in the three areas. Results: The authors found that the content of the coursebooks were incomplete and outdated, the teachers lacked practical ability and were unaware of data analysis tools. Furthermore, their teaching methods were inefficient. Conclusions: The study reconstructs the financial analysis courses based on three aspects. First, the contents are supplemented with enterprise strategy, macro-environment analysis, industry analysis, business analysis, and the application of data analysis tools. Second, the teachers can work in the company to develop their vocational skills, and participate in training programs to learn data analysis tools. Third, the teaching methods can be dynamic and dual-purpose by cooperating with enterprises to enrich practical teaching. Furthermore, colleges and enterprises can make enterprise work a teaching task, develop simulation training platforms, and provide vocational skill grade certificates.
Endometriosis - Pathogenesis, diagnosis and treatment
Authors: Kwiatkowski Piotr , Gładysz Konrad , Szydłowska Justyna , Żuchnik Olga , Król Olgierd , Kuczyńska Beata , Czelej Magdalena , Kłos Aleksander , Gieroba Krzysztof , Szydłowski Marcin 
Published: February 2023

Introduction: Endometriosis is defined as a chronic gynecological disease characterized by endometrial tissue outside the uterus. The condition affects 5-10% of women of reproductive age worldwide and is associated with pelvic pain and infertility. Despite its prevalence, diagnosis is usually delayed for many years which postpones the introduction of appropriate treatment.
Aim of the study: Summary of the current state of knowledge on endometriosis, analyzing the pathogenesis, the current diagnostic approach, highlighting the problem of fertility in this disease entity and presenting treatment options.
Methods and materials: A review of the literaturę available in the PubMed database and GoogleScholar from the last 5years was conducted,using the following keywords: endometriosis”, „endometriosis pathogenesis”, „endometriosis diagnosis”, „infertility in endometriosis”, „endometriosis treatment”
Results: Among the etiological factors mentioned are congenital, environmental, epigenetic, autoimmune and allergic factors. The main theory for the formation of the condition is retrograde menstruation through the fallopian tubes into the peritoneal cavity and implantation of endometrial cells. Laparoscopy is nowadays the gold standard for diagnosis, but less invasive methods that can shorten the time to diagnosis are being sought. Current treatment is limited to surgery, hormonal treatment and analgesics which are associated with many side effects.
Conclusion: Endometriosis is the cause of infertility, chronic pain and reduced quality of life in many women. Non-invasive diagnostic tests such as imaging studies, genetic tests, biomarkers or miRNAs have diagnostic potential but more analysis is needed to be applied in daily clinical work. Future research should focus on learning and understanding the pathogenesis, identifying subtypes of the disease, and a modern approach to diagnosis and comprehensive treatment taking into account concomitant general symptoms.
Softening Competition Through Unilateral Sharing of Customer Data
Authors: Choe Chongwoo , Cong Jiajia , Wang Chengsi 
Published: February 2023

We study how a data-rich firm can benefit by unilaterally sharing its customer data with a data-poor competitor when the data can be used for price discrimination. By sharing data on the segment of market that is more loyal to the competitor and keeping the data on the competitor’s most loyal segment to itself, the firm can induce the competitor to raise its price for consumers on which it does not have data. Such data sharing is an example of a fat-cat strategy as it softens price competition that follows data sharing. Although consumer surplus decreases as a result of data sharing, total surplus can increase when the sharing firm concedes its market share to the competitor, which improves the quality of consumer–firm matching. This paper was accepted by Joshua Gans, business strategy. Funding: C. Choe and C. Wang gratefully acknowledge financial support from the Australian Research Council [Grant DP210102015]. J. Cong would like to acknowledge the financial support from the National Natural Science Foundation of China [Grants 72003035, 72192845] and Shanghai Pujiang Program [Grant 2019PJC007]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4689 .
Moral Foundations, Himpathy, and Punishment Following Organizational Sexual Misconduct Allegations
Authors: Dodson Samantha J. , Goodwin Rachael D. , Graham Jesse , Diekmann Kristina A. 
Published: February 2023

We build on deontic justice and moral foundations theories to shed light on responses to sexual misconduct at work by proposing a model that explains why some third parties punish accusing victims and support alleged perpetrators. We theorize that when third parties are given conflicting he-said, she-said information, they intuitively evaluate organizational injustice based on moral values. We further theorize that binding moral foundations (loyalty, authority, purity) give rise to sympathy toward men accused of sexual misconduct and anger toward female accusers. Across five studies (total n = 5,413) utilizing archival, field, and vignette designs, we examined third-party responses to sexual misconduct accusations ranging in severity across several industries. Third-party endorsement of binding moral foundations was linked to increased perpetrator-directed sympathy and victim-directed anger (Studies 1–4). These emotions jointly mediated the relationship between binding values and credibility perceptions of the accusing victim and the alleged perpetrator (Studies 2 and 3). Moreover, victim credibility was negatively associated with social sanctions and punishment severity levied toward the accusing victim, and perpetrator credibility was negatively associated with the same punishment outcomes for the alleged perpetrator (Studies 3 and 4). In Study 5, we found that managers framing the accusing victim as disloyal exacerbated negative judgments and emotions toward the victim and positive judgments and emotions toward the perpetrator for individuals who highly ascribe to binding moral foundations. We discuss the theoretical contributions and practical implications of moral concerns on third parties’ emotions, judgments, and motivations to punish actors involved in sexual misconduct allegations. Supplemental Material: The e-companion is available at https://doi.org/10.1287/orsc.2022.1652 .