bluuebunny/crossref_metadata_2025_split huggingface dataset:
C3 glomerulopathy post kidney transplantation: A single center experience
Authors: Zuckerman Jonathan , Pham Phuong-Thu , Parakkal Meena , Velazquez Alexis F , Sarkar Mrinalini , Pablos Michael A , Bunnapradist Suphamai , Lum Erik L 
Published: February 2025

BACKGROUND
C3 glomerulopathies (C3G) are a rare cause of kidney failure resulting from complement dysregulation. Small studies demonstrate a high rate of recurrence and poor outcomes in kidney transplantation. Treatment efficacy in this setting with eculizumab, a terminal complement inhibitor, is largely unknown.
AIM
To determine the outcomes of kidney transplantation in patients with C3G and the potential impact of eculizumab.
METHODS
We retrospectively studied kidney transplant recipients who underwent a post-transplant biopsy confirming C3G between January 1, 1993 and December 31, 2023 at a single center. Only the first episode of kidney transplant was reviewed. The electronic medical records were reviewed for post-transplant allograft function, indication for biopsy, time to biopsy from transplant, time to allograft failure from transplantation, post-C3G treatment, complement laboratory testing, and concurrent malignancy/infection. Reports, and when available slides and immunofluorescence/electron microscopic images, were re-reviewed by a renal pathologist.
RESULTS
A total of fifteen patients were included in this study. Fourteen patients had suspected recurrent disease, with a pre-transplant native kidney report of C3G. One patient developed de novo C3G. Median post kidney transplant clinical follow up time was 91 months. Median time to recurrence was 7 months with median graft survival of 48 months post kidney transplantation. The most common index biopsy pattern of injury was endocapillary proliferative glomerulonephritis (often with exudative features) with or without mesangial hypercellularity (56%) followed by membranoproliferative glomerulonephritis (25%). Most patients developed membranoproliferative glomerulonephritis pattern of injury on follow up biopsies (63%). Seven patients with recurrent disease received treatment with eculizumab with a median graft survival of 73 months, with five functioning grafts by the end of the study period. Seven patients with recurrent disease did not receive therapy, and all lost their graft with a median graft survival of 22 months (P = 0.003).
CONCLUSION
C3G following kidney transplantation is mostly a recurrent disorder with a poor prognosis in untreated patients. Untreated recurrence has a poor prognosis with median allograft survival < 2 years. Early treatment with eculizumab may improve transplant outcomes in patients with recurrent C3G.
Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for CYP3A5-polymorphism in kidney-transplant recipients
Authors: Dung Pham-Thai , Su Hoang-Xuan , Tue Nguyen-Chi , Ben Nguyen-Huu , Phuong Nguyen-Minh , Tran Tuan-Ngoc , Nghia Phan-Ba , Van Diem-Thi , Dung Nguyen Thi-Thuy , Vinh Hoang-Trung , Rostaing Lionel , Toan Pham-Quoc 
Published: February 2025

BACKGROUND
Tacrolimus (TAC) is metabolized primarily by the CYP3A -encoded enzyme family (CYP3A4 , CYP3A5 , and CYP3A7 ). Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to reach therapeutic levels.
AIM
To evaluate the predictive value of the TAC concentration-to-dose (C0/D) ratio for identifying CYP3A5 polymorphisms in renal transplant recipients.
METHODS
Eighty-six de novo kidney transplant recipients with TAC-based immunosuppression from the Department of Nephrology and Dialysis at Military Hospital 103 (Hanoi, Vietnam) were included in this retrospective study. Blood samples were collected within the first week post-transplantation to monitor TAC levels and to perform genotyping for CYP3A5 genetic polymorphisms.
RESULTS
The CYP3A53/3 genotype was identified in 37 patients (43%), CYP3A51/3 in 40 patients (46.5%), and CYP3A51/1 in 9 patients (10.5%). Patients carrying the CYP3A51/3 or CYP3A51/1 genotype, classified as fast metabolizers (CYP3A5 expressers), had significantly lower TAC C0 concentrations and C0/D ratios compared to slow metabolizers (CYP3A53/3 genotype) at multiple time points during follow-up (all P < 0.001). Notably, the TAC C0/D ratio obtained on day 1 (0.91) was shown to predict CYP3A5 polymorphism with a sensitivity of 84.6% and a specificity of 84.6%.
CONCLUSION
This study demonstrates that the TAC C0/D ratio provides a reliable predictive value for CYP3A5 polymorphisms, which can be used to individualize TAC dosing in renal transplant recipients in Vietnam and other low-income countries.
Effect of frailty as measured by functional impairment on long-term outcomes in liver transplantation in the United States
Authors: Balogh Julius , Mubashir Talha , Li Yuan , Digbeu Biai D , Hegde Nikita , Pour Fatemeh Movaghari , Rezapour Mohsen , Lai Hong-Yin , West Kelly , Chaudhry Rabail A , Williams George W , Maroufy Vahed 
Published: February 2025

BACKGROUND
In patients with chronic liver disease or hepatic dysfunction with sarcopenia, there is an increased risk of frailty as measured by functional impairment, making frailty a vital predictor of post-transplant mortality.
AIM
To investigate the effects of frailty on mortality after liver transplantation.
METHODS
A retrospective review of post-transplant outcomes in liver transplant recipients assessed frailty using Karnofsky Performance Score. Data from the Scientific Registry of Transplant Recipients database for 37427 liver transplant recipients was used.
RESULTS
Of 82.7% frail patients, 42.7% were severely frail and 40% were moderately frail (P < 0.001) at the time of transplantation. Compared with non-frail patients, post-transplant mortality in frail patients was significantly higher at 12 months [odds ratio (OR) = 1.94, P = 0.02)]. Secondary analysis of the data revealed that liver grafts from donation after circulatory death (DCD) were more likely to be associated with frail patients at transplant (OR = 1.86, P < 0.001). Furthermore, a donor history of hypertension was associated with a lower likelihood of frailty in the recipient at the time of transplant (OR = 0.65, P = 0.03).
CONCLUSION
Recipient frailty is associated with increased mortality at 12 months following liver transplantation, and liver transplants from donors with DCD are associated with increased frailty of the liver transplant recipient.
Estimativa da evapotranspiração de referência pela equação de Hargreaves em clima do tipo subtropical
Authors: Lima Layla Gerusa Souza , Turco José Eduardo Pitelli , Souza Luma Castro de , Souza Leane Castro de , Nascimento José Henrique dos Santos , Meneses Ana Luisa da Conceição de Sousa , Rodrigues Nailson Mateus Lima , Silva Ângela Maria Campelo da , Pereira Gustavo Lima , Melo Nilvan Carvalho , Ferreira Raphael Leone da Cruz , Silva-Matos Raissa Rachel Salustriano da , Farias Maryzelia Furtado de 
Published: February 2025

Uma forma de verificar a eficiência de métodos de estimativa da evapotranspiração de referência (ET0) é comparar com equação de Penman-Monteith FAO-56, recomendado pela FAO para estimar a evapotranspiração de referência (ET0). Com este trabalho o objetivo foi avaliar a equação de Hargreaves, comparando-a com a equação de Penman-Monteith FAO-56, para verificar a possibilidade de estimar a evapotranspiração de referência para as condições climáticas do município de Jaboticabal – SP e fazer a calibração local desta equação. Para esse fim, foram utilizados dados do período de 01/01/2009 a 31/12/2015 de uma estação meteorológica automatizada instalada na área experimental do Departamento de Engenharia Rural da FCAV/UNESP, Câmpus de Jaboticabal, SP. Por intermédio da estação meteorológica, foram obtidas medidas da radiação solar global, radiação líquida, temperatura do ar, umidade relativa do ar, velocidade do vento. A análise dos resultados foi realizada aplicando técnicas que verificam a integridade dos dados meteorológicos e utilizando metodologias de análise dos dados médios e desvios padrões da ETo. Foi realizado a calibração local da equação de Hargreaves por meio do ajuste do parâmetro empírico HE (expoente empírico de Hargreaves) da equação. A integridade dos dados da estação meteorológica foi aceitável. O resultado de avaliação do método, utilizando a metodologia de análise de desvios padrões diários da ETo, considerando a equação de Penman-Monteith FAO-56 como padrão, indica que estabeleceu uma relação linear. Portanto, podem ser comparados. A equação de Hargreaves é uma opção para estimar os valores de ETo em clima do tipo subtropical, em locais em que a disponibilidade de dados climáticos é limitada.
Perspectives on Mental Health Challenges and Needs: A Qualitative Study of Adolescents in Incarceration
Authors: Zulhaini Sartika A. Pulungan , S. Hamid Achir Yani , Susanti Herni , Yusna Dewid Suzy 
Published: February 2025

Introduction: The global community is increasingly recognizing the importance of mental health. However, adolescents in correctional institutions are often overlooked and do not have sufficient access to the mental health services they need. These young individuals have the same right to proper care and support. This study aims to explore the challenges and needs related to adolescent mental health while serving sentences in correctional facilities. Methods: This study utilized a qualitative research design with a phenomenological approach to explore experiences within the prison system. Participants were selected using purposive sampling based on specific criteria, resulting in 30 individuals: nine adolescent inmates, eight caregivers, five nurses, and eight prison officers. The characteristics of participants were analyzed using frequency distribution and measures of central tendency. Qualitative data from interviews were examined through thematic analysis to identify key themes and patterns reflecting the complex realities of those in the prison environment.Results: This study identified four themes: 1) Transition experience during legal proceedings, 2) Risk factors for adolescent mental health problems, 3) Protective factors of adolescent development, and 4) The need to handle mental health problems.Conclusion: Incarceration creates significant psychological stress for adolescents, contributing to anxiety and mental health issues. Factors such as violence during arrest, stigma, and isolation worsen these problems. However, family support, education, and positive activities can help. Comprehensive mental health interventions, including regular check-ups, are essential for the well-being of detained adolescents.
ALLELIC AND GENOTYPIC FREQUENCY OF THE KAPPA CASEIN GENE IN DOUBLE PURPOSE CATTLE
Authors: Cortes Lopez Noemi Gabriela , Del Moral Ventura Sandra Trinidad , RuedaBarrientos Jose Angel , Luna Palomera Carlos , Meza Herrera Cesar Alberto , Abad-Zavaleta Jose 
Published: February 2025

<p>In this work, allelic frequencies (A and B) of <em>CAS</em><em>k</em><em> </em>gene were determined as selection criteria on milk quality in double purpose cattle. Blood samples were taken at 200 bovine females and were placed in tubes containing EDTA. Genetic marker MB002 was amplified from extracted genetic material. RFLP testing was performed using restriction enzyme <em>Hinf</em><em> I</em> for the diagnosis of A and B alleles on <em>CASκ</em>. Genotype frequencies obtained corresponded to 0.34, 0.01 and 0.65 for AA, BB and AB, respectively. Allelic frequency were 0.67 and 0.33 for A and B alleles, respectively. Also, there was a heterocigocity average of 0.6481. The study population is not in Hardy Weinberg equilibrium, the value of c2 = 14.8 with 2 degrees of freedom (P &lt; 0.005). Based on allelic frequency of <em>CAS</em><em>k</em> B (0.34) observed in this study under theoretical assumptions, double-purpose cattle may be a feasible option to increase milk quality when BB sires are used for cross breeding. In this way, B alleles associated to higher milk quality can be enriched in few generations.</p>
Sosialisasi Budi Daya Mangrove dalam Upaya Pelestarian Ekosistem dan Peningkatan Kesejahteraan Masyarakat Pesisir di Pantai Bagan Serdang Kecamatan Pantai Labu Kabupaten Serdang Bedagai
Authors: Rinanda Teja , Helman Helman , Herlina Herlina , Sibuea Nurhalimah , Tarigan Purnaya Sari , Suwianto Suwianto 
Published: February 2025

Mangrove merupakan ekosistem pesisir yang vital dengan berbagai manfaat ekologis dan ekonomi. Kerusakan hutan mangrove yang terus meluas mendorong upaya budidaya untuk memulihkan dan melestarikannya. Kegiatan ini bertujuan untuk menganalisis teknik budidaya mangrove, manfaatnya bagi lingkungan dan masyarakat pesisir, serta tantangan dan peluang dalam pengembangannya. Metode pelaksanaan pengabdian kepada masyarakat yang dilakukan di Pantai Bagan Serdang Kecamatan Pantai Labu Kabupaten Serdang Bedagai pada tanggal 26 Februari 2024. Yang menjadi sasaran dalam pengabdian ini adalah masyarakat disekitar panati bagan serdang. Budidaya mangrove merupakan upaya penting untuk melestarikan ekosistem pesisir dan meningkatkan kesejahteraan masyarakat. Pemerintah, organisasi non-pemerintah, dan masyarakat perlu bekerja sama untuk mengatasi tantangan dan mengembangkan budidaya mangrove secara berkelanjutan.Kata Kunci: Sosialisasi; Budi Daya Mangrove; Upaya Pelestarian Ekosistem; Peningkatan Kesejahteraan Masyarakat.
Peran Digitalisasi dan Berpikir Kreatif dalam Penyerapan Inovasi Produk Bagi Anak-Anak di Yayasan Panti Asuhan RAHPIA Medan
Authors: Tampubolon Lasma Ria , Syah Putri Tantri Octora Dwi , Nasution Isna Asdiani 
Published: February 2025

Kegiatan pengabdian masyarakat yanga laksanakan sebagai upaya untuk memberikan pengetahuan dan wawasan kepada anak-anak panti asuhan. Pada era teknologi yang semakin canggih oleh kareana itu anak-anak panti nantinya dalam mengikuti perkembangan pendidikan yang berinovasi baik berupa penyerapan komunikasi dimedia social. Dengan pemberian pengetahuan anak- anak panti asuhan Rahpia memiliki bekal atau dasar yang nantinya akan sangat berguna bagi pendidikan mereka selanjutnya. Baik dalam penyerapan pendidkan dan menyalurkan bakat mereka di internet. Kegiatan dillakukan dengan memberikan presentasi sebagai perkenalan dalam penggunaan digital agar anak-anak panti dapat mengerti dan memahami pengguna digital baik bersifat positif dan negatif .Kata Kunci: Peran Digitalisasi; Berpikir Kreatif; Inovasi Produk.
Pelatihan Program Volunteer Teaching untuk Mengatasi Tantangan Kesulitan Belajar Anak
Authors: Tarigan Fatin Nadifa , Fauzi Fikriyah Iftinan , Sari Fatnida 
Published: February 2025

Pelatihan Volunteer Teaching dirancang untuk membekali relawan dengan pengetahuan dan keterampilan dasar dalam membantu anak-anak dengan kesulitan belajar. Program ini melibatkan 20 peserta dari berbagai latar belakang. Materi pelatihan mencakup pengenalan jenis kesulitan belajar, teknik pengajaran inklusif, dan komunikasi empatik. Hasil pelatihan menunjukkan peningkatan pemahaman peserta sebesar 35% berdasarkan hasil wawancara dan kuesioner. Sebagian besar peserta (85%) mampu menerapkan teknik pengajaran inklusif dalam simulasi praktik, sementara 80% menunjukkan peningkatan keterampilan komunikasi. Umpan balik peserta mengindikasikan bahwa pelatihan ini relevan dan bermanfaat, meskipun durasi yang terbatas menjadi kendala dalam pendalaman materi. Untuk keberlanjutan program, disarankan adanya pengembangan modul tambahan dan kolaborasi dengan lembaga pendidikan. Secara keseluruhan, pelatihan ini membuktikan bahwa workshop berbasis praktik efektif untuk meningkatkan kompetensi relawan dalam mendukung pendidikan inklusif.
An outbreak of Mycoplasma pneumoniae infections in Louisville, KY: Clinical practice and public health implications.
Authors: Raghuram Anupama , Rashid Salwa , Prado Josue , Furmanek Stephen , Chandler Thomas , Mattingly William , Companioni Cruz Maikel , Pubillones Izaguirre Alexeis , Ramirez Julio 
Published: February 2025

Background After the COVID-19 pandemic, a re-emerging of Mycoplasma pneumoniae infections has been reported globally. The objective of this study is to define the epidemiology of M. pneumoniae in the city of Louisville. Methods All cases of M. pneumoniae infection since January 1, 2017 until December 31, 2024 were evaluated. A baseline cohort from January 1, 2017 to March 31, 2020 was used to develop the expected upper control limits for detecting infection. Infections were aggregated by annual quarter and depicted in c-charts. Results An outbreak was identified starting in the fourth quarter of 2023, when the number of infections due to M. pneumoniae exceeded the upper control limit set by the baseline cohort. The current outbreak has affected 925 patients with M. pneumonaie infection. Conclusions We documented a current outbreak of M. pneumoniae infections in Louisville, starting in the fourth quarter of 2023. This outbreak of respiratory infections due to an atypical pathogen has implications for clinicians and public health professionals. This outbreak highlights the importance of active surveillance of respiratory pathogens.
Educating Orthopaedic Surgery Residents in the Dictation of Operative Notes
Authors: Lauter Mia , Gentile Bailey , Rumps Mia , Mulcahey Mary K. 
Published: February 2025

Purpose The purpose of this study was to analyze the existing literature to determine if and how surgical residents are taught to dictate operative notes. The secondary aim was to compile perceptions regarding the teaching and quality of resident operative dictation (OD) and ways in which teaching might be improved. # Method A systematic review was performed following PRISMA guidelines. PubMed, CINAHL, Web of Science, and EMBASE were searched for studies related to operative note dictation in U.S. surgical residency programs from 2010-2023. Results The initial search yielded 782 results, which were screened by two independent reviewers (MVL and BCG), resulting in 9 studies that met the inclusion criteria. These studies, covering various surgical subspecialties, revealed that while 44%-67% of surveyed surgical residency program directors (PDs) prioritize teaching OD, only 17% currently provide formal education in this area. Notably, synoptic reports, which employ templates with discrete data fields, demonstrated significantly greater completeness (94.7%) compared to traditional dictated operative reports (66%). Completeness of resident OD did not correlate with level of training, and pertinent information was lacking at all resident PGY-levels. Educational interventions in the form of lectures and video instruction improved the completeness of OD by up to 22%. Conclusions Despite the crucial role of OD in patient care, medicolegal aspects, and billing, this review underscores a lack of routine and formal instruction of this skill in U.S. surgical residency programs. Limited studies suggest potential improvement through formal educational interventions. Future research should delve into the costs and barriers hindering the integration of formal dictation training, shedding light on why PDs have not universally adopted such initiatives.
“Responsabilidad por daños de productos y servicios sanitarios equipados con sistemas de inteligencia artificial”
Authors: González-García Viñuela María 
Published: February 2025

The incorporation of artificial intelligence systems into healthcare products and services is revolutionising the world of medicine. The effectiveness of these advances depends, to a large extent, on the existence of a regulation that guarantees fundamental rights and is capable of delimiting the non-contractual liability that must be demanded for damage caused by health products and services that incorporate artificial intelligence systems, and of identifying the liable parties. This paper studies the existing possibilities for the enforcement of this liability and the recently approved European regulation to this effect.
La incorporación de sistemas de inteligencia artificial a productos y servicios sanitarios está revolucionando el mundo de la medicina. La eficacia de estos avances depende, en buena medida, de la existencia de una normativa que garantice los derechos fundamentales y sea capaz de delimitar la responsabilidad extracontractual que debe exigirse por los daños causados por productos y servicios sanitarios que incorporen sistemas de inteligencia artificial, y de identificar a los sujetos responsables. En este trabajo se estudian las posibilidades existentes para la exigencia de esta responsabilidad y la regulación europea aprobada recientemente al efecto.
Retos éticos y jurídicos de la restauración de la naturaleza: enfoque One Health y protección de la biodiversidad
Authors: Lofaro Giuseppina 
Published: February 2025

“One Health” encompasses a transdisciplinary approach to health and greater holistic collaboration across sectors to address emerging risks and create the conditions for transformative resilience. The One Health approach has assumed a key role also in response to other zoonotic, public health emergencies. It should be the right solution to promote, support and strengthen inter-disciplinary and intersectoral actions and strategies that address not only disease prevention, but also biodiversity conservation, climate change, sustainable development and the resilience of human health. Building future perspectives from a One Health perspective requires capacity, among health stakeholders, to incorporate environmental health dimensions with integration of national One Health Platforms; Integrative governance is essential to simplify the response at the local level to co-manage human, animal and environmental health. The goal is to reduce the possibility of prevalence and future outbreaks and contribute to a healthier and more sustainable planet.
“One Health” abarca un enfoque transdisciplinario de la salud y una mayor colaboración holística entre sectores para abordar los riesgos emergentes y crear las condiciones para una resiliencia transformadora. El enfoque One Health ha asumido un papel clave también en respuesta a otras emergencias zoonótico, de salud pública. Él debería estar la solución adecuada para promover, apoyar y fortalecer acciones y estrategias interdisciplinarias e intersectoriales que aborden no sólo prevención de enfermedades, pero también conservación de la biodiversidad, cambio el clima, el desarrollo sostenible y la resiliencia de la salud humana. Construir perspectivas de futuro desde una perspectiva Única Sanidad necesita capacidad, entre los interesados de la salud, para incorporar dimensiones salud ambiental con integración de Plataformas nacionales One Health; gobernancia de integración es fundamental para simplificar la respuesta a nivel local para cogestionar salud humana, animal y ambiental. La óptica es reducir la posibilidad de prevalencia y futuros brotes e contribuir a un planeta más saludable y sostenible.
GASTRONOMÍA Y HOSPITALIDAD: CLAVES PARA LA SATISFACCIÓN TURÍSTICA EN ÁREAS RURALES
Authors: Martínez-Roget Fidel 
Published: February 2025

Hospitality is one of the most significant attractions of a destination and one of the factors that most influences tourist satisfaction. The perception of hospitality depends on both the attitudes of residents and the cultural involvement of tourists. The results of the study confirmed that motivation related to gastronomy and the consumption of local products positively influences perceived hospitality. Additionally, perceived hospitality influences the destination image and is the most important factor in explaining visitor satisfaction.
La hospitalidad es uno de los atractivos más importantes de un destino y uno de los factores que más influye en la satisfacción del turista. La percepción de hospitalidad depende tanto de las actitudes de los residentes como de la implicación cultural de los turistas. Los resultados del trabajo confirmaron que la motivación relacionada con la gastronomía y el consumo de productos locales influye positivamente en la hospitalidad percibida. Además, la hospitalidad percibida influye en la imagen del destino y es el factor más importante a la hora de explicar la satisfacción de los visitantes.