bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning models for hepatitis E incidence prediction leveraging meteorological factors
Authors: Feng Yi , Cui Xiya , Lv Jingjing , Yan Bingyu , Meng Xin , Zhang Li , Guo Yanhui 
Published: March 2023

BackgroundInfectious diseases are a major threat to public health, causing serious medical consumption and casualties. Accurate prediction of infectious diseases incidence is of great significance for public health organizations to prevent the spread of diseases. However, only using historical incidence data for prediction can not get good results. This study analyzes the influence of meteorological factors on the incidence of hepatitis E, which are used to improve the accuracy of incidence prediction.MethodsWe extracted the monthly meteorological data, incidence and cases number of hepatitis E from January 2005 to December 2017 in Shandong province, China. We employ GRA method to analyze the correlation between the incidence and meteorological factors. With these meteorological factors, we achieve a variety of methods for incidence of hepatitis E by LSTM and attention-based LSTM. We selected data from July 2015 to December 2017 to validate the models, and the rest was taken as training set. Three metrics were applied to compare the performance of models, including root mean square error(RMSE), mean absolute percentage error(MAPE) and mean absolute error(MAE).ResultsDuration of sunshine and rainfall-related factors(total rainfall, maximum daily rainfall) are more relevant to the incidence of hepatitis E than other factors. Without meteorological factors, we obtained 20.74%, 19.50% for incidence in term of MAPE, by LSTM and A-LSTM, respectively. With meteorological factors, we obtained 14.74%, 12.91%, 13.21%, 16.83% for incidence, in term of MAPE, by LSTM-All, MA-LSTM-All, TA-LSTM-All, BiA-LSTM-All, respectively. The prediction accuracy increased by 7.83%. Without meteorological factors, we achieved 20.41%, 19.39% for cases in term of MAPE, by LSTM and A-LSTM, respectively. With meteorological factors, we achieved 14.20%, 12.49%, 12.72%, 15.73% for cases, in term of MAPE, by LSTM-All, MA-LSTM-All, TA-LSTM-All, BiA-LSTM-All, respectively. The prediction accuracy increased by 7.92%. More detailed results are shown in results section of this paper.ConclusionsThe experiments show that attention-based LSTM is superior to other comparative models. Multivariate attention and temporal attention can greatly improve the prediction performance of the models. Among them, when all meteorological factors are used, multivariate attention performance is better. This study can provide reference for the prediction of other infectious diseases.
Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks
Authors: Kikukawa Yasushi , Tanaka Shin , Kosugi Takuya , Pflugfelder Stephen C. 
Published: March 2023

Purpose
Dry eye disease affects hundreds of millions of people worldwide and is one of the most common causes for visits to eye care practitioners. The fluorescein tear breakup time test is currently widely used to diagnose dry eye disease, but it is an invasive and subjective method, thus resulting in variability in diagnostic results. This study aimed to develop an objective method to detect tear breakup using the convolutional neural networks on the tear film images taken by the non-invasive device KOWA DR-1α.

Methods
The image classification models for detecting characteristics of tear film images were constructed using transfer learning of the pre-trained ResNet50 model. The models were trained using a total of 9,089 image patches extracted from video data of 350 eyes of 178 subjects taken by the KOWA DR-1α. The trained models were evaluated based on the classification results for each class and overall accuracy of the test data in the six-fold cross validation. The performance of the tear breakup detection method using the models was evaluated by calculating the area under curve (AUC) of receiver operating characteristic, sensitivity, and specificity using the detection results of 13,471 frame images with breakup presence/absence labels.

Results
The performance of the trained models was 92.3%, 83.4%, and 95.2% for accuracy, sensitivity, and specificity, respectively in classifying the test data into the tear breakup or non-breakup group. Our method using the trained models achieved an AUC of 0.898, a sensitivity of 84.3%, and a specificity of 83.3% in detecting tear breakup for a frame image.

Conclusions
We were able to develop a method to detect tear breakup on images taken by the KOWA DR-1α. This method could be applied to the clinical use of non-invasive and objective tear breakup time test.
Etiology of gender incongruence and its levels of evidence: A scoping review protocol
Authors: Rojas Saffie Juan Pablo , Eyzaguirre Bäuerle Nicolás 
Published: March 2023

IntroductionGender Incongruence refers to the discordance between biological sex and gender identity. Although it is possible to find literature reviews about the etiology of Gender Incongruence, almost all of these correspond to non-systematic narrative reviews, so they do not make explicit the methodology used in the collection and analysis of sources, even less its levels of evidence. In order to remedy this, we will conduct a scoping review to answer the question: what are the factors associated with gender incongruence and what level of evidence is there for each factor in the scientific literature?Methods and analysisWe will conduct a scoping review according to the methodology specified in the JBI Manual for Evidence Synthesis (Chapter 11) and the PRISMA extension for scoping reviews (PRISMA-ScR). Four databases will be reviewed to identify papers that match our search criteria, followed by a screening of titles and abstracts, the complete reading of those articles that have not been excluded, and the coding of these using the data extraction instrument developed for this research (see S1 Appendix). Data extracted will be analyzed in terms of frequency counts of factors, types of factors and levels of evidence for each factor. Results will be presented in tabular or diagrammatic forms supported by a narrative summary.FindingsThe present review will help to map the factors associated with incongruence between biological sex and gender identity, specifying their levels of evidence. This evidence-based knowledge will be useful for clinicians evaluating gender incongruence, especially given that international guidelines recommend careful assessment of factors that may interfere with the clarity of gender identity development and decision making.
IMPORT AT MANUFACTURING ENTERPRISES OF THE ALTAI TERRITORY: ANALYSIS, ASSESSMENT, PROSPECTS
Authors: Borodin V.A. , Shamkov A.Yu. 
Published: March 2023

An assessment of the situation with import substitution at manufacturing enterprises in the Altai Territory based on an analysis of the effectiveness of foreign purchases carried out by these enterprises is the purpose of writing this article.
The authors used the results of studies by Russian and foreign authors on the strategy and tactics of the behavior of enterprises in matters of importing raw materials, materials, technological equipment and technologies under the sanctions regime introduced by the countries of the European Union and the United States in the period 2017-2022, as well as statistical data from Rosstat and Office of the Federal State Statistics Service for the Altai Territory and the Republic of Altai, materials of the Altai Branch of the Russian Union of Industrialists and Entrepreneurs and data from a survey of industrial enterprise managers.
Using the example of manufacturing enterprises in the region, the actual situation with import supplies is shown at the present time, an assessment is made of the situation with import substitution at innovatively active enterprises. It that as a result of the import substitution policy, the dependence of has been established manufacturing enterprises on foreign supplies has decreased. Nevertheless, work in this direction now needs to be increased, especially, in the opinion of the interviewed heads of Barnaul enterprises, especially modern technologies and equipment based on the formation and implementation of federal programs for the dynamic development of mechanical engineering.
ASSESSMENT OF THE FINANCIAL SECURITY OF A COMPANY WITH STATE PARTICIPATION
Authors: Prikhodko E.A. , Zheleznyak M.E. 
Published: March 2023

An assessment of the economic, including financial, security of an organization plays an indispensable role in making managerial decisions that affect the process of formation and development of regional and national markets for goods, works and services. The economic security of an organization has rather unstable development trends, so analysts tend to describe options for ensuring it not only for short-term prospects for the development of production, but also to look further a year or several years ahead. The use of analytical procedures in assessing the level of financial security helps specialists to analyze indicators of economic security, and the manager to coordinate the activities of the organization, orienting production to improve indicators in places where financial risks are most affected.
The subject of research in the article is the process of assessing the financial security of an organization with state participation using analytical audit procedures. The study discusses the author's approach to assessing financial security, which allows you to identify areas of damage to financial security and focus on areas of increased risk. The research methodology is based on the application of general scientific methods of analysis, such as the synthesis of the obtained data, comparison and others, as well as specific analytical procedures.
An Evaluation of a 1/18o Resolution Regional Ocean Circulation Model of CROCO in the Southern Sunda Shelf
Authors: Apriansyah Apriansyah , Atmadipoera Agus S. , Jaya Indra , Nugroho Dwiyoga , Akhir Mohd. Fadzil 
Published: March 2023

The Coastal and Regional Ocean Community Model (CROCO) was applied to simulate the three dimensional ocean circulation on the southern Sunda Shelf with a horizontal resolution of 1/18o and 40 vertical layers. This configuration is called as CROCO18-SSS. The initial and open boundary conditions were derived from a global reanalysis product at a resolution of 1/12o from the Copernicus Marine Environment Monitoring Service (CMEMS). The regional model was driven by atmospheric, tides, and river discharges data from a wide variety of datasets, each with a different resolution. To test the model performance and capabilities of the CROCO18-SSS model outputs including sea level anomaly, current velocity, temperature, salinity, and volume transport, we have compared in the simulation results with other reanalysis product and satellite-derived datasets. The CROCO18-SSS model outputs reproduced the regional ocean circulation well from observations and reanalysis products. For example, the reversal of the monsoonal current in the southern sunda shelf, as well as strong persistent southward Makassar throughflow and their interaction in the southern Makassar Strait, can be seen clearly. The vertical structure of the zonal current component was comparable to that of the reanalysis product reference. The seasonal shift in temperature and salinity, with the water becoming colder and saltier during the northwest monsoon and warmer and fresher during the southeast monsoon, was also accurately reproduced by the CROCO18-SSS model. Additionally, the mean volume transport calculated by the CROCO18-SSS model for the Makassar and Karimata Straits was comparable to that reported in previous studies.
A strophe, a chorus, and a bridge walk into a bar…
Authors: Martinelli Dario 
Published: March 2023

Abstract
Building up on Paul Cobley’s work on narrativity in film and literature, the present article aims at exploring how pop songs convey narrative elements via their own structure (or “format,” as it shall be called here), and their single components (intro, outro, bridge, refrain, etc.). Some of the most recurrent formats (particularly Strophe–Refrain and Chorus–Bridge) as well as some of the most unusual ones (e.g. the suite) are discussed within the framework of the three main narrative movements analyzed by Cobley (realism, modernism, and postmodernism), and additional parallels with literature and cinema will be proposed in the area of what here will be called “conceptual space” (diegesis, non-diegesis, fourth wall, etc.).
Transcending the mid-most target: Paul Cobley and the cultural implications of biosemiotics
Authors: Favareau Donald 
Published: March 2023

Abstract
Having been intimately aligned with the research agenda of biosemiotics since his colleague Thomas Sebeok first started using the term in 1992, Paul Cobley has consistently argued against the idea that the primary aim of biosemiotics is to make an intervention in the discourse and epistemology of the life sciences. Instead, he argues for the potential of a biosemiotically informed humanities for refashioning the ways in which we humans come to understand our situation within a world of signs and other organisms – as well as our existential duty of care for preserving the diversity and flourishing of both through the development of an anti-volunteerist ethics. Paul Cobley’s 2016 Cultural implications of biosemiotics fills a much-needed lacuna in the literature of biosemiotics in focusing with laser-like precision on those aspects of our human being – politics and aesthetics, education and ideology – that, Cobley rightly claims, have gone disproportionately under-analyzed and even under-appreciated in biosemiotics, due to its competing emphasis on reformulating biology. As one of the justly accused, I would like to take the occasion of this Festschrift to show the extent to which I now believe that Paul’s more expansive understanding of the purview of biosemiotics is, indeed, the proper one.
Living the duty of care: languaging in semiotic fields
Authors: Cowley Stephen J. 
Published: March 2023

AbstractNew hope can draw on anti-humanist duty of care. Turning from debate about how oneoughtto act in discursively produced “realities,” Paul Cobley advocates a bioethics of living in semiotic fields. Thanks to observership, humans can make good use of both the known and howthings appear as signs. For Cobley, the latter are “mind independent.” Once deemedreal, semiosis can unite the lawful, the perceivable and, at least, some of the unknown. However, skeptical as I am about metaphysics and mind, I shift the focus to languaging in semiotic fields: human perceiving, doing, and saying entangle languaging with nature’s simplex tricks (Berthoz, Alain. 2012.Simplexity: Simplifying principles for a complex world. New Haven, CT: Yale University Press). An ethical dimension runs through how we feel, speak and, thus, actualize practices. The duty of care, the known, the knowable, and the unknowable unite inthingishness. What appear to us as signs ensure that perceiving-acting can draw, at times, on fictions and, at others, precision tools. Humans tether sense to wordings as, without end, we actualize practices. Stories bring ethical awareness to attitudes, action, and the due care that shapes understanding and response to institutions. In offering a distributed perspective on language, one makes possible an ecolinguistics that works for life-sustaining relations between humans, nonhumans and what we call “things.”
Hyers-Ulam stability of isometries on bounded domains-II
Authors: Choi Ginkyu , Jung Soon-Mo 
Published: March 2023

Abstract
The question of whether there is a true isometry approximating the

ε

\varepsilon

-isometry defined in the bounded subset of the

n

n

-dimensional Euclidean space has long been considered an interesting question. In 1982, Fickett published the first article on this topic, and in early 2000, Alestalo et al. and Väisälä improved Fickett’s result significantly. Recently, the second author of this article published a paper improving the previous results. The main purpose of this article is to significantly improve all of the aforementioned results by applying a basic and intuitive method.
Asymptotic study of Leray solution of 3D-Navier-Stokes equations with exponential damping
Authors: Blel Mongi , Benameur Jamel 
Published: March 2023

Abstract
We study the uniqueness, the continuity in

L

2

{L}^{2}

, and the large time decay for the Leray solutions of the 3D incompressible Navier-Stokes equations with the nonlinear exponential damping term

a

(

e

b
∣
u

∣

2

−
1

)

u

a\left({e}^{b| u{| }^{{\bf{2}}}}-1)u

, (

a
,
b
>
0

a,b\gt 0

).
Lack of exposure to pharmacogenomics education among the health care providing students in the West Bank of Palestine
Authors: Jarrar Yazun , Musleh Rami , Hamdan Anas , Ghanim Mustafa , Alqub Malik , Abudahab Sara 
Published: March 2023

Abstract

Objectives
Evaluating the knowledge in pharmacogenomics (PGx) is the first step toward the implementation of PGx testing in clinical practice. This survey aimed to evaluate the knowledge of PGx testing among healthcare providing students at the top-ranked university in the West Bank of Palestine.

Methods
First an online questionnaire consisting of 30 questions regarding the demographic, knowledge, and attitude toward pharmacogenomics testing was structured and validated. Then the questionnaire was distributed to 1,000 current students from different fields.

Results
696 responses was received. The results showed that almost half of the participants (n=355, 51.1%) have never took any courses about PGx during their university training. Only 81 (11.7%) of the students who took the PGx course stated that it helped them understanding how genetic variations affect drug response. The majority of the students were uncertain (n=352, 50.6%) or disagreed (n=143, 20.6%) that the lectures during university education described the effects of genetic variants on drug response. Although most of the students (70–80%) answered that genetic variants can indeed affect the drug’s response, only 162 students (23.3%) responded that VKORC1 and CYP2C9 genotypes influence the response to warfarin. In addition, only 94 (13.5%) students were aware that many medicine labels include clinical information about PGx testing provided by the FDA.

Conclusions
It is concluded from the results of this survey that there is a lack of exposure to PGx education associated with poor knowledge of PGx testing among the healthcare providing students in the West Bank of Palestine. It is recommended to include and improve the lectures and courses regarding PGx as this will have a major impact on precision medicine.
Isolation and purification of high-molecular weight hemicelluloses from radiata pine wood chips prior to thermo-mechanical pulp (TMP) production
Authors: Widsten Petri , Murton Karl , Thumm Armin , Bridson James H. 
Published: March 2023

Abstract
A novel thermo-mechanical pulping (TMP) process has been developed to produce a by-product rich in high-molecular weight (MW) hemicelluloses, a potential raw material for barrier coatings and films. This process uses prehydrolysis to solubilise the hemicelluloses followed by chip compression to separate the soluble material from the wood matrix. The pressate from the chip compression stage was dark-coloured and had a high content of high-MW hemicelluloses and lignin. However, isolating the high-MW material from the pressate directly by ultrafiltration was not feasible because of membrane fouling by dissolved lignin and wood extractives, while coloured impurities are undesirable for many potential applications. To solve these problems the pressate was purified using XAD adsorbent resin to remove low-MW lignin, extractives and colour. Ultrafiltration of the purified pressate yielded lightly coloured high-MW hemicellulose with a low content of lignin and well suited for barrier films and coatings.
Synthetic biology open language (SBOL) version 3.1.0
Authors: Buecherl Lukas , Mitchell Thomas , Scott-Brown James , Vaidyanathan Prashant , Vidal Gonzalo , Baig Hasan , Bartley Bryan , Beal Jacob , Crowther Matthew , Fontanarrosa Pedro , Gorochowski Thomas , Grünberg Raik , Kulkarni Vishwesh , McLaughlin James , Mısırlı Göksel , Oberortner Ernst , Wipat Anil , Myers Chris 
Published: March 2023

Abstract
Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. When designing a synthetic system, synthetic biologists need to exchange information about multiple types of molecules, the intended behavior of the system, and actual experimental measurements. The Synthetic Biology Open Language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, following an open community process involving both bench scientists and scientific modelers and software developers, across academia, industry, and other institutions. This document describes SBOL 3.1.0, which improves on version 3.0.0 by including a number of corrections and clarifications as well as several other updates and enhancements. First, this version includes a complete set of validation rules for checking whether documents are valid SBOL 3. Second, the best practices section has been moved to an online repository that allows for more rapid and interactive of sharing these conventions. Third, it includes updates based upon six community approved enhancement proposals. Two enhancement proposals are related to the representation of an object’s namespace. In particular, the Namespace class has been removed and replaced with a namespace property on each class. Another enhancement is the generalization of the CombinatorialDeriviation class to allow direct use of Features and Measures. Next, the Participation class now allow Interactions to be participants to describe higher-order interactions. Another change is the use of Sequence Ontology terms for Feature orientation. Finally, this version of SBOL has generalized from using Unique Reference Identifiers (URIs) to Internationalized Resource Identifiers (IRIs) to support international character sets.
Comparison of regular with NPH insulin vs. premix insulin in children and adolescents with type 1 diabetes in a resources-limited setting: a retrospective data analysis
Authors: Sagna Yempabou , Bagbila Wend Pagnangde Abraham Hermann , Bognounou René , Ilboudo Alassane , Sawadogo Nongoba , Kyelem Carole G. , Guira Oumar , Ouedraogo Macaire S. , Drabo Joseph Y. 
Published: March 2023

Abstract

Objectives
Few studies addressed the efficacy of human insulin regimens (mostly premix insulin) used in many low-and-middle income countries on glycemic control of children and adolescents with diabetes. The aim of this study was to assess the efficacy of the premix insulin on the glycated hemoglobin (HbA1c) in comparison to the regular with NPH insulin scheme.

Methods
A retrospective study was carried out from January 2020 to September 2022 on patients with type 1 diabetes aged below 18 years followed in Burkina Life For A Child program. They were categorized into three groups, on regular with NPH insulin (Group A), on premix insulin (Group B) and on regular with premix insulin (Group C). Outcome was analyzed based on HbA1c level.

Results
Sixty-eight patients with a mean age of 15.38 ± 2.26 years and the sex ratio (M/W) 0.94 were studied. There were 14 in Group A, 20 in Group B, and 34 patients in Group C. The mean HbA1c value in the corresponding insulin regimen was 12.8 ± 1.39%, 9.87 ± 2.18%, and 10.66 ± 2.1%, respectively. Glycemic control was better in Groups B and C than Group A (p<0.05) but there was no difference between groups B and C.

Conclusions
Our results indicate that the use of premix insulin gives a better glycemic control than NPH insulin. However, further prospective study of these insulin regimens with a strengthening education strategy and glycemic control by continuous glucose monitoring and HbA1c is required to corroborate these preliminary findings.