bluuebunny/crossref_metadata_2025_split huggingface dataset:
Color multilayer holographic near-eye augmented reality display
Authors: Velez-Zea Alejandro , Barrera-Ramírez John Fredy 
Published: June 2023

AbstractThis study demonstrates a full-color near-eye holographic display capable of superimposing color virtual scenes with 2D, 3D, and multiple objects with extended depth upon a real scene, which also has the ability to present different 3D information depending on the focus of the user’s eyes using a single computer-generated hologram per color channel. Our setup makes use of a hologram generation method based on two-step propagation and the singular value decomposition of the Fresnel transform impulse response function to efficiently generate the holograms of the target scene. Then, we test our proposal by implementing a holographic display that makes use of a phase-only spatial light modulator and time-division multiplexing for color reproduction. We demonstrate the superior quality and computation speed of this approach compared with other hologram generation techniques with both numerical and experimental results.
Micro mercury trapped ion clock prototypes with 10$$^{-14}$$ frequency stability in 1-liter packages
Authors: Hoang Thai M. , Chung Sang K. , Le Thanh , Park Sehyun , Park Sung-Jin , Eden J. Gary , Holland Christopher , Wang Hao , Momeni Omeed , Bradley Russell , Crane Scott , Prestage John D. , Yu Nan 
Published: June 2023

AbstractModern communication and navigation systems are increasingly relying on atomic clocks. As timing precision requirements increase, demands for lower SWaP (size, weight, and power) clocks rise. However, it has been challenging to break through the general trade-off trend between the clock stability performance and SWaP. Here we demonstrate micro mercury trapped ion clock (M2TIC) prototypes integrated with novel micro-fabricated technologies to simultaneously achieve high performance and low SWaP. The M2TIC prototypes could reach the$$10^{-14}$$10-14-stability level in 1 day with a SWaP of 1.1 L, 1.2 kg, and under 6 W of power. This stability level is comparable to the widely used rack-mount Microchip 5071A cesium frequency standard. These standalone prototypes survived regular commercial shipping across the North American continent to a government laboratory, where their performance was independently tested. The M2TIC sets a new reference point for SWaP and performance and opens opportunities for high-performance clocks in terrestrial and space applications.
RETRACTED ARTICLE: Therapeutic effect of melatonin-loaded chitosan/lecithin nanoparticles on hyperglycemia and pancreatic beta cells regeneration in streptozotocin-induced diabetic rats
Authors: Alaa Habiba , Abdelaziz Mariam , Mustafa Maryam , Mansour Mustafa , Magdy Salma , Mohsen Salma , El-Karamany Yomna , Farid Alyaa 
Published: June 2023

AbstractNanotechnology is used to overcome fundamental flaws in today's marketed pharmaceuticals that obstruct therapy, like restricted solubility and quick release of drugs into the bloodstream. In both human and animal researches, melatonin was demonstrated to regulate glucose levels. Despite the fact that melatonin is quickly transported through the mucosa, its sensitivity to be oxidized creates a difficulty in achieving the required dose. Additionally, due to its variable absorption and poor oral bioavailability necessitates the development of alternative delivery methods. The study aimed to synthesize melatonin loaded chitosan/lecithin (Mel-C/L) nanoparticles to be assessed in the treatment of streptozotocin (STZ)-induced diabetes in rats. The antioxidant, anti-inflammatory, and cytotoxicity properties of nanoparticles were estimated to determine the safety of manufactured nanoparticles for in vivo studies. In addition, Mel-C/L nanoparticles were administered to rats for eight weeks after inducing hyperglycemia. The therapeutic effect of Mel-C/L nanoparticles was assessed in all experimental groups by detecting insulin and blood glucose levels; observing improvements in liver and kidney functions as well as histological and immunohistochemical evaluation of rats’ pancreatic sections. The results proved that Mel-C/L nanoparticles showed remarkable anti-inflammatory, anti-coagulant, and anti-oxidant effects, in addition to its efficiency in reducing blood glucose levels of STZ-induced diabetic rats and great ability to promote the regeneration of pancreatic beta (β)-cells. Furthermore, Mel-C/L nanoparticles elevated the insulin level; and decreased the elevated levels of urea, creatinine and cholesterol. In conclusion, nanoparticles application decreased the administrated melatonin dose that in turn can diminish the side effects of free melatonin administration.
Videos posted on the internet provide evidence for joint rushing in naturalistic social interactions
Authors: Wolf Thomas , Novák Tamás , Knoblich Günther 
Published: June 2023

AbstractWhen people engage in rhythmic joint actions, they unintentionally increase their tempo. However, this phenomenon of joint rushing has so far been investigated only under very specific and somewhat artificial conditions. Therefore, it remains unclear whether joint rushing generalizes to other instances of rhythmic joint action. In this study our aim was to investigate whether joint rushing can also be observed in a wider range of naturalistic rhythmic social interactions. To achieve this, we retrieved videos of a wide range of rhythmic interactions from an online video-sharing platform. The data suggest that joint rushing indeed can also be observed in more naturalistic social interactions. Furthermore, we provide evidence that group size matters for how tempo unfolds in social interactions with larger groups showing a stronger tempo increase than smaller groups. Comparing the data from naturalistic interactions with data collected in a lab study further showed that unintended tempo changes in social interactions are reduced in naturalistic interactions compared to interactions in a lab context. It is an open question which factors led to this reduction. One possibility is that humans might have come up with strategies to reduce the effects of joint rushing.
Disabled and Romani passengers face similar levels of discrimination but different levels of open hostility in the sharing economy
Authors: Simonovits Borbála , Kurdi Benedek , Simonovits Gábor 
Published: June 2023

AbstractThis multimethod project investigates discrimination against members of two populous minority groups in the European Union: the Roma (numbering 6 million) and the disabled (numbering 100 million) on a leading Hungarian carpooling platform. In a field experiment, 1005 ride requests were sent to drivers, with passenger group membership (control, disabled, Roma) manipulated between participants. Widespread discrimination against both groups was apparent in significantly lower approval rates for disabled (56%) and Roma passengers (52%) relative to control (70%). Mechanisms driving anti-disabled and anti-Roma discrimination were probed using an experimental manipulation, natural language processing analysis of driver–passenger interactions, and an online survey (N = 398). Individuating information in the form of reviews did not mitigate unequal treatment, thus providing evidence against statistical (stereotype-based) discrimination. Militating against taste-based (attitudinal) discrimination, respondents reported negative attitudes toward Roma passengers but positive attitudes toward disabled passengers. Moreover, despite equivalent approval rates, disabled passengers were more likely to receive a response from drivers and received more polite responses than Roma passengers did. Overall, the observed patterns are most readily explained by intergroup emotions: Contempt toward Roma passengers likely engenders both passive and active harm, whereas pity toward disabled passengers likely engenders passive harm and active facilitation.
An investigation of simulated and real touch on feelings of loneliness
Authors: Gray Nicholas L. T. , Roberts S. Craig 
Published: June 2023

AbstractAs a social species, humans deprived of contact find loneliness a potentially distressing condition. Recent research emphasises the influence of touch on alleviating loneliness. This research found that touch reduces feelings of neglect, a subscale of loneliness. Affectionate touch, which demonstrates care or affection, has been previously linked to well-being in couples. Here, we investigated whether the effect of simulated touch during a video conversation might be sufficient to influence feelings of loneliness. Sixty participants answered a survey about their home life and relationships, including items that assessed the frequency of touch and feelings of loneliness. Following this, they participated in an online video call with three conditions: audio only, audio and video, or audio, video with simulated touch (a virtual ‘high-five’). Finally, immediately after the call, they repeated the loneliness questionnaire. We found that loneliness scores were reduced following the call, but there was no difference among conditions and no effect of a virtual touch. However, we did find a significant association between the frequency of touch in a relationship and the expression of loneliness, with individuals in low-touch relationships having loneliness scores more comparable to single participants than to those in high-touch relationships. Additionally, extraversion played a major role in moderating the effect of touch in relationships. These results emphasise the importance of physical contact in lowering feelings of loneliness within relationships and the ability of calls to lower feelings of loneliness, regardless of whether they include video or simulated touch.
Dapagliflozin and short-term changes on circulating antigen carbohydrate 125 in heart failure with reduced ejection fraction
Authors: Amiguet Martina , Palau Patricia , Domínguez Eloy , Seller Julia , Pinilla Jose Manuel Garcia , de la Espriella Rafael , Miñana Gema , Valle Alfonso , Sanchis Juan , Górriz Jose Luis , Bayés-Genís Antoni ,   DAPA VO2 investigators, Domíngueza Eloy , Sastre Clara , Miñana Gema , Santas Enrique , Mollar Anna , Civera Jose , Conesa Adriana , Zakarne Rim , Larumbe Ainoha , Pinilla Jose Manuel Garcia , Doblas Juan Jose Gómez , Mezcua Ainhoa Robles , Miñana Gema , Bodí Vicent , Pascual-Figal Domingo , Rubio Clara Jiménez , Cabeza Alejandro I. Pérez , Expósito Arancha Díaz , Carmona José David Martínez , Morales Manuel Luna , Sánchez Francisco J. Zafra , Trujillo Ángel Montiel , Climent Herminio Morillas , Núñez Julio 
Published: June 2023

AbstractCirculating antigen carbohydrate 125 (CA125) has emerged as a proxy of fluid overload in heart failure. This study aimed to evaluate the effect of dapagliflozin on short-term CA125 levels in patients with stable heart failure with reduced ejection fraction (HFrEF) and whether these changes mediated the effects on peak oxygen consumption (peakVO2). This study is a post-hoc sub-analysis of a randomized, double-blinded clinical trial in which 90 stable patients with HFrEF were randomly assigned to receive either dapagliflozin or placebo to evaluate change in peakVO2 (NCT04197635). We used linear mixed regression analysis to compare changes in the natural logarithm of CA125 (logCA125) and percent changes from baseline (Δ%CA125). We used the “rwrmed” package to perform mediation analyses. CA125 was available in 87 patients (96.7%). LogCA125 significantly decreased in patients on treatment with dapagliflozin [1-month: Δ − 0.18, (CI 95% = − 0.33 to − 0.22) and 3-month: Δ − 0.23, (CI 95% = − 0.38 to − 0.07); omnibus p-value = 0.012]. Δ%CA125 decreased by 18.4% and 31.4% at 1 and 3-month, respectively (omnibus p-value = 0.026). Changes in logCA125 mediated the effect on peakVO2 by 20.4% at 1 month (p < 0.001). We did not find significant changes for natural logarithm of NTproBNP (logNT-proBNP) [1-month: Δ − 0.03, (CI 95% = − 0.23 to 0.17; p = 0.794), and 3-month: Δ 0.73, (CI 95% = − 0.13 to 0.28; p-value 0.489), omnibus p-value = 0.567]. In conclusion, in patients with stable HFrEF, dapagliflozin resulted in a significant reduction in CA125. Dapagliflozin was not associated with short-term changes in natriuretic peptides. These changes mediated the effects on peakVO2.
The concentration of particulate matter in the barn air and its influence on the content of heavy metals in milk
Authors: Nieckarz Zenon , Pawlak Krzysztof , Baran Agnieszka , Wieczorek Jerzy , Grzyb Jacek , Plata Patrycja 
Published: June 2023

AbstractHeavy metals are one of the components of smog, which is mainly the product of burning fossil fuels in residential buildings. These elements, introduced into the body of cattle by inhalation, may enter the milk. The goal of this study was to assess the impact of particulate pollution in the atmospheric air on the concentration of particulate matter in the air of a dairy cattle barn and on the content of selected heavy metals in milk from cows present in the building. Measurements were taken between November and April (148 measurement days). The calculations carried out showed a high correlation (RS = + 0.95) between the concentrations of particulates measured outside and inside the barn, which is indicative of a significant impact of the atmospheric air on the particulate pollution level of the livestock building. The number of days in excess of the daily standard for PM10 inside was 51. The conducted analysis of the chemical composition of the milk collected under high particulate pollution (February) showed that the permitted lead level had been exceeded—21.93 µg/kg (norm 20.00 µg/kg).
Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration
Authors: Ozawa Yoko , Ohgami Kazuhiro , Sasaki Koji , Hirano Kazufumi , Sunaya Toshiyuki 
Published: June 2023

AbstractThis prospective, multicentre, postmarketing surveillance were conducted to report on the long-term safety and effectiveness of intravitreal aflibercept (IVT-AFL) treatment in clinical practice of Japanese patients with neovascular age-related macular degeneration (nAMD) who newly initiated IVT-AFL treatment. The primary outcomes were the incidence of adverse events (AEs) and of adverse drug reactions (ADRs) over 36 months. Number of injections, timing of ADR occurrence, and some effectiveness index were also summarised. A total of 3,872 patients received 7.2 ± 5.8 (mean ± standard deviation) injections, and AEs occurred in 5.73% of patients. ADRs were reported in 2.76% of patients, with ocular and nonocular ADRs in 2.07% and 0.72% of patients, respectively. Most vitreo-retinal events developed within 6 months of initial IVT-AFL treatment, and most instances of increased intraocular pressure and cerebral infarction developed after 6 months of follow-up. Mean best-corrected visual acuity and central retinal thickness were numerically better throughout the follow-up period compared with baseline. These results indicated acceptable tolerability and effectiveness of IVT-AFL treatment in patients with nAMD in clinical practice in Japan. Information regarding the risk and the timing of ADRs is valuable for safe and effective long-term treatment of patients with nAMD.Trial registration number: NCT01756248.
A neonicotinoid pesticide alters Drosophila olfactory processing
Authors: Tatarko Anna R. , Leonard Anne S. , Mathew Dennis 
Published: June 2023

AbstractNeonicotinoid pesticides are well-known for their sublethal effects on insect behavior and physiology. Recent work suggests neonicotinoids can impair insect olfactory processing, with potential downstream effects on behavior and possibly survival. However, it is unclear whether impairment occurs during peripheral olfactory detection, during information processing in central brain regions, or in both contexts. We used Drosophila melanogaster to explore the potential for neonicotinoids to disrupt olfaction by conducting electrophysiological analyses of single neurons and whole antennae of flies exposed to varying concentrations of the neonicotinoid imidacloprid (IMD) that were shown to cause relative differences in fly survival. Our results demonstrated that IMD exposure significantly reduced the activity of a single focal olfactory neuron and delayed the return to baseline activity of the whole antenna. To determine if IMD also impacts olfactory-guided behavior, we compared flies’ relative preference for odor sources varying in ethanol content. Flies exposed to IMD had a greater relative preference for ethanol-laced pineapple juice than control flies, demonstrating that neuronal shifts induced by IMD that we observed are associated with changes in relative preference. Given the interest in the sensory impacts of agrochemical exposure on wild insect behavior and physiology, we highlight the potential of Drosophila as a tractable model for investigating the effects of pesticides at scales ranging from single-neuron physiology to olfactory-guided behavior.
Application of structural equation modelling to inform best management strategies for Marek’s disease in Amhara region, Ethiopia
Authors: Birhan Mastewal , Berhane Nega , Ibrahim Saddam Mohammed , Dejene Haileyesus , Dessalegn Bereket , Woldemichael Wubet Weledemedhin , Gelaye Esayas , Getachew Belayneh , Abayneh Takele , Bitew Molalegne 
Published: June 2023

AbstractMarek’s disease, a highly contagious and an economically significant oncogenic and paralytic viral diseases of poultry, is becoming a serious problem in Ethiopia’s poultry sector. The aim of the study was to examine the relationship between risk factors and their contribution to develop risk with the intentions to implement MD control measures in the different chicken production systems of Ethiopia using the SEM framework. A questionnaire was designed based on the framework and each model constructed was measured using a set of rating scale items. Thus, a sample size of 200 farmers from different production systems were chosen for the data collection. From the analysis, Cornbrash’s Alpha (coefficient of reliability) based on the average inter-item correlations were evaluated for each parameter. The result showed that when litter management goes up by 1, the number of sick goes down by 37.575, the number of staff goes up by 1, the number of sick goes down by 7.63, litter management goes up by 1, the number of deaths goes down by 2.505, flock size goes up by 1, the number of deaths goes down by 0.007 than the rest of the activities. The result of this structural equation modeling finding indicates that the data fit the model well (χ2 = 0.201, RMSEA = 0.000, CFI = 1.00, TLI = 1.496, Degrees of freedom = 2) and the model was appropriated. In conclusion, flock size, litter management and number of staff activities have more impact on the numbers of sick, drops in egg production and the number of deaths. Therefore, practicing regular awareness creation for producers regarding management techniques is recommended.
Engine performance and emissions evaluation of surfactant-free B30 biodiesel–diesel/water emulsion as alternative fuel
Authors: Mohd Tamam Mohamad Qayyum , Omi Md Reashed Tasvir , Yahya Wira Jazair , Ithnin Ahmad Muhsin , Abdul Rahman Hasbullah , Rahman Md. Mujibur , Abd Kadir Hasannuddin , Noge Hirofumi , Koga Tsuyoshi , Hong Chungpyo , Otaka Takeshi , Kinoshita Eiji 
Published: June 2023

AbstractMalaysia is one of the top exporters of palm oil, and although currently facing fierce resistance towards palm oil imports in some parts of the globe, one of the ways to utilize this commodity is by increasing palm biodiesel content in local commercial diesel. However, due to the oxygen-rich nature of biodiesel, its utilization suffers from increased nitrogen oxides (NOx) emission compared to conventional diesel. To mitigate this issue and improve diesel engine performance and emissions using biodiesel–diesel blends, this study attempted to investigate implementation of a real-time non-surfactant emulsion fuel supply system (RTES) which produces water-in-diesel emulsion as fuel without surfactants. NOx reducing capability of water-in-diesel produced by RTES has been well documented. Therefore, in this study, 30% biodiesel–diesel (B30) was used as the base fuel while B30-derived emulsions consisting of 10 wt%, 15 wt% and 20 wt% water content were supplied into a 100 kVA, 5.9-L common rail turbocharged diesel engine electric generator. Fuel consumption and exhaust emissions were measured and compared with commercially available Malaysian low grade diesel fuel (D2M). Evidence suggested that emulsified B30 biodiesel–diesel produced by RTES was able to increase brake thermal efficiency (BTE) up to a maximum of 36% and reduce brake specific fuel consumption (BSFC) up to 8.70%. Furthermore, B30 biodiesel–diesel emulsions produced significantly less NOx, carbon monoxide and smoke at high engine load. In conclusion, B30 biodiesel–diesel emulsions can be readily utilized in current diesel engines without compromising on performance and emissions.
The impact of comorbidities and COVID-19 on the evolution of community onset sepsis
Authors: de Araújo Giovanna Colantuono , Pardini Andrea , Lima Camila 
Published: June 2023

AbstractSepsis is a disease with high mortality and morbidity despite advances in diagnostic procedures and therapeutic strategies. The aim of this study was to evaluate the profile and outcomes of community-onset sepsis. This retrospective, multicenter study included five 24-h health care units and was conducted from January 2018 to December 2021. Patients were diagnosed with sepsis or septic shock according to the Sepsis 3.0 criterion. A total of 2630 patients diagnosed as having sepsis (68.4%, 1800) or septic shock (31.6%, 830) in the 24-h health care unit were included; 43.76% of the patients were admitted to the intensive care unit, 12.2% died, 4.1% had sepsis and 30% had septic shock. The comorbidities that were independent predictors of septic shock were chronic kidney disease on dialysis (CKD-d), bone marrow transplantation and neoplasia. CKD and neoplasia were also independent predictors of mortality, with ORs of 2.00 (CI 1.10–3.68) p = 0.023 and 1.74 (CI 1.319–2.298) p =  < 0.0001, respectively. Mortality according to the focus of primary infection was as follows: pulmonary 40.1%; COVID-19 35.7%; abdominal 8.1% and urinary 6.2%. Mortality due to the COVID-19 outbreak had an OR of 4.94 (CI 3.08–8.13) p ≤ 0.0001. Even though community-onset sepsis can be potentially fatal, this study revealed that some comorbidities lead to an increased risk of septic shock (d-CKD and neoplasia) and mortality. COVID-19 infection as the primary focus was an independent predictor of mortality in patients with sepsis when compared to other foci.