bluuebunny/crossref_metadata_2025_split huggingface dataset:
Class Ⅱb Histone Deacetylase Participates in Postoperative Cognitive Dysfunction in Elderly Mice via HSP90/GR Signaling Pathway
Authors: Liu Yu , Wang Xinlin , Wang Jiao , Jin Qiqi , Cai Weicha , Pan Chi , Nivar John , Tao Yuanxiang , Cao Hong , Li Jun 
Published: August 2023

Abstract
Objective: Multiple factors contribute to the development of perioperative neurocognitive disorders (PND). This study was designed to investigate whether group class Ⅱb histone deacetylases were involved in the formation of postoperative cognitive dysfunction in elderly mice by regulating the degree of acetylation of HSP90 and related protein functions and quantities.
Methods: C57BL/6J male mice were randomly divided into five groups: control naive (group Control), anesthesia (group Anesthesia, referred to as anesthesia group), anesthesia plus splenectomy surgery (group Surgery), anesthesia plus splenectomy surgery plus the inhibitor ACY-1215 (group Ricolinostat), and anesthesia plus splenectomy surgery plus dissolvent (group Vehicles). After the mice were trained for Morris Water Maze (MWM) test for five days, anesthesia and operational surgery were carried out on the following day. Cognitive function was assessed on 1st and 3rd days post-surgery. The hippocampi were harvested on days 1, 3, and 7 post-surgeries for quantitative RT-PCR, Western blots, and ELISA assays.
Results: The mice with the splenectomy surgery displayed impaired spatial learning and memory in the MWM test, which marked the increase of the HDAC6 and deacetylated its downstream protein HSP90 at the molecular level. The hippocampus of surgical groups showed a decrease in acetylated HSP90, a rise in GR-HSP90 association, and an increase in GR translocation. The HDAC6 inhibitor can partly reverse the effect of the operation.
Conclusions: Abdominal surgery may impair hippocampal spatial memory, possibly through the increased HDAC6- triggered increase in the function of HSP90 and consequent strengthen in the negative role of steroids in cognitive function. Targeting HDAC6 may provide a potential avenue in the treatment of the impairment of cognitive function after surgery.
Statistically downscaled CMIP6 ocean variables for European waters
Authors: Kristiansen Trond , Butenschön Momme , Peck Myron 
Published: August 2023

Abstract

Climate change impact studies need climate projections at scales relevant to planning and management and to be available across a range of climate scenarios. To address current gaps, we statistically downscaled (SD) 4–7 CMIP6 models for four key indicators of marine habitat conditions: temperature, salinity, oxygen, and chlorophyll across European waters for three climate scenarios SSP1-2.6, SSP2-4.5, and SSP5-8.5. The results provided ensemble averages and uncertainty estimates to serve as input data for projecting the potential success of a range of Nature-based Solutions, including the restoration of habitat-forming species like seagrass in the Mediterranean and kelp in coastal areas of Portugal and Norway. Validation of the ensemble with observations of four European regions (North Sea, Baltic Sea, Bay of Biscay, and Mediterranean Sea) indicated that the SD projections realistically captured the climatological conditions of the historical period 1993–2020. Model skill (Liu-Mean Efficiency, Pearson correlation) clearly improved for both surface temperature and oxygen across all regions with a higher skill for temperature than oxygen with a difference of 0.2–0.4 points. Warming was evident across all areas and large differences among scenarios fully emerged from the background uncertainties related to internal variability and model differences in the second half of the century. Scenario-specific differences in acidification significantly emerged from model uncertainty and internal variability leading to distinct trajectories in surface pH starting from before mid-century (e.g., present day). Deoxygenation is present across all domains, but the signal was significantly weaker compared to the other two pressures when compared to model uncertainty and internal variability. The impact of different greenhouse gas trajectories was also less distinct. There was substantial regional to local heterogeneity in these quantitively characteristics underscoring the importance of highly spatially resolved physical and biogeochemical projections to address how climate change may impact marine ecosystems.
Stochastic modeling of spatial dependency structures of extreme precipitation in the Northern Great Plains using max-stable processes
Authors: Boluwade Alaba 
Published: August 2023

AbstractThe objective of this study is to quantify the spatial dependency and trend of annual maxima precipitation (annual highest daily precipitation, from 1970 to 2020) across selected weather stations in the Nelson Churchill River Basin (NCRB) of North America. This study uses max-stable processes to examine spatial extremes of annual maxima precipitation. The generalized extreme value (GEV) parameters are expressed as simple linear combinations of geographical coordinates (i.e., longitude and latitude) and topography. The results show that topography, geographical coordinates, and time (as a temporal covariate) were important covariates in reproducing the stochastic extreme precipitation field using the spatial generalized extreme value (SPEV). The inclusion of time as a covariate further confirms the impacts of climate change on extreme precipitation in the NCRB. The fitted SPEV was used to predict the 25- and 50-year return period levels. The fitted Extremal-t max-stable process model captured the spatial dependency structure of the extreme precipitation in the NCRB. The study is relevant in quantifying the spatial dependency structure of extreme precipitation in the Northern Great Plains. The result will contribute as a decision-support system in climate adaptation strategies in the United States and Canada.
Equity analysis of intermittent water supply systems by means of EPA-SWMM
Authors: Ceita Paulo A. S. B. , Mahamed Ismail Mahamud , Ferras David , Trifunović Nemanja , Kennedy Maria 
Published: August 2023

Abstract

Intermittent water supply (IWS) is a frequent operation approach in developing countries. A number of factors contribute to IWS, such as leakage and water shortage, leading to inequitable water distribution. A way to reduce the inequity in IWS systems is by planning or adapting the network for equitable water distribution, which requires software capable of describing IWS conditions, including not only pressurized flow but also free-surface. In this paper, a new index for equity analysis is presented and compared with the existing indices available in scientific literature. The comparison is based on the EPA-SWMM modelling framework and standard IWS operations, including pipe emptying and filling, have been considered. Results reveal that EPA-SWMM has great potential in simulating IWS systems, especially in the application for equity analyses, as it provides a more realistic description of the pipe filling and emptying operations compared to standard water distribution modelling software. Furthermore, a novel equation called volumetric coefficient was developed which has a significant advantage in identifying the nodes with a higher impact on network equity, and ensuring the fair distribution of supply along the distribution network, considering the relevance of nodal demand, which none of the other indexes in the literature were addressed.
Alkaloids as Vasodilator Agents: A Review
Authors: Amssayef Ayoub , Eddouks Mohamed 
Published: August 2023

Abstract:
The pathophysiology of hypertension is often associated with endothelial dysfunction and the impairment
of endothelium-dependent vasodilation mechanisms, as well as alterations in vascular smooth muscle (VSM)
tone. Natural products, particularly alkaloids, have received increased attention in the search for new vasodilator
agents. This review aims to summarize the noteworthy results from ex-vivo and in-vitro studies that explored
the vasodilatory effects of some selected alkaloids (Berberine, Sinomenine, (S)-Reticuline, Neferine, Nuciferine,
Villocarine A, 8-Oxo-9-Dihydromakonakine, Harmaline, Harman, and Capsaicin) and the underlying
mechanisms implicated. The results obtained from the literature revealed that these selected alkaloids exhibited
vasodilation in various vascular models, including mesenteric, carotid, and coronary arteries, thoracic aorta,
and cultured HUCECs and VSMCs. Furthermore, most of these alkaloids induced vasodilation through endothelium-
dependent and endothelium-independent mechanisms, which were primarily mediated by activating
eNOS/NO/sGC/cGMP pathway, opening various potassium (K+) channels, or modulating calcium (Ca2+) channels.
Additionally, several alkaloids exerted vasodilatory effects through multiple mechanism pathways. Moreover,
different alkaloids demonstrated the ability to protect endothelial function by reducing oxidative stress, endoplasmic
reticulum and inflammation. In conclusion, this class of secondary metabolites holds interesting therapeutic
potential in the prevention and treatment of cardiovascular diseases (CVD), particularly hypertension.
Functional Chitosan: Recent Gamma Radiation Chemistry of Organic Derivatives
Authors: Torres Maykel González 
Published: August 2023

Abstract:
This Special Issue will cover the recent radiation chemistry of chitosan (CS) and the attempts that researchers have made to prepare a plethora of derivatives for diverse synthetic applications. The cutting-edge science carried out by experts regarding the gamma-radiation-induced synthesis methods, types of monomers used for grafting the CS, and enhanced properties of the new organic compounds are provided here.
Neural Oscillation Disorder in the Hippocampal CA1 Region of Different
Alzheimer's Disease Mice
Authors: Yuan Weiming , Zhi Weijia , Ma Lizhen , Hu Xiangjun , Wang Qian , Zou Yong , Wang Lifeng 
Published: August 2023

Background:
Alzheimer's disease (AD) is a well-known neurodegenerative disease that
gradually induces neural network dysfunction and progressive memory deficits. Neural network activity
is represented by rhythmic oscillations that influence local field potentials (LFPs). However,
changes in hippocampal neural rhythmic oscillations in the early stage of AD remain largely unexplored.

Objective:
This study investigated neural rhythmic oscillations in 3-month-old APP/PS1 and 5x-
FAD mice to assess early neural connectivity in AD.

Methods:
LFPs were recorded from the hippocampal CA1 region with implanted microelectrode arrays
while the mice were in the awake resting stage. Welch fast Fourier transforms, continuous
wavelet transforms, and phase-amplitude coupling analyses were used to compute the power density
of different frequency bands and phase-amplitude modulation indices in the LFPs.

Results:
Our results showed impaired theta, low gamma, and high gamma frequency band power
in APP/PS1 and 5xFAD mice during the awake resting stage. AD mice also showed decreased delta,
alpha, and beta frequency band power. Impaired theta-low gamma and theta-high gamma phaseamplitude
coupling were observed in 5xFAD mice.

Conclusion:
This study revealed neural network activity differences in oscillation power and
cross-frequency coupling in the early stage of AD, providing a new perspective for developing biomarkers
for early AD diagnosis.
Peripheral Neuroinflammation and Pain: How Acute Pain Becomes
Chronic
Authors: Schumacher Mark A. 
Published: August 2023

Abstract:
The number of individuals suffering from severe chronic pain and its social and financial
impact is staggering. Without significant advances in our understanding of how acute pain becomes
chronic, effective treatments will remain out of reach. This mini review will briefly summarize how
critical signaling pathways initiated during the early phases of peripheral nervous system inflammation/
neuroinflammation establish long-term modifications of sensory neuronal function. Together with
the recruitment of non-neuronal cellular elements, nociceptive transduction is transformed into a pathophysiologic
state sustaining chronic peripheral sensitization and pain. Inflammatory mediators, such
as nerve growth factor (NGF), can lower activation thresholds of sensory neurons through posttranslational
modification of the pain-transducing ion channels transient-receptor potential TRPV1 and
TRPA1. Performing a dual role, NGF also drives increased expression of TRPV1 in sensory neurons
through the recruitment of transcription factor Sp4. More broadly, Sp4 appears to modulate a nociceptive
transcriptome including TRPA1 and other genes encoding components of pain transduction. Together,
these findings suggest a model where acute pain evoked by peripheral injury-induced inflammation
becomes persistent through repeated cycles of TRP channel modification, Sp4-dependent overexpression
of TRP channels and ongoing production of inflammatory mediators.
Design, Development, and In vitro Evaluation of Single Unit Hydrodynamically
Balanced System of Captopril
Authors: Soni Shashank , Bahuguna Deepankar 
Published: August 2023

Background:
This study investigated the use of in situ polyelectrolyte complex formation by using two oppositely charged polysaccharides [Chitosan (cationic), Sodium Alginate (anionic)]. It forms 3-D intercalation and interpenetrating network helping in controlling the release of highly acid-soluble Captopril.

Objective:
To develop a polyelectrolyte complex based single unit gastroretentive tablet by using optimization based 3 (2) Taguchi factorial design for controlled delivery of Captopril.

Materials and Methods:
Gastroretentive Captopril tablets were prepared by the direct compression technique. Total 09 batches were prepared as per 3 (2) Taguchi factorial design studies of 100 tablets each.

Results:
Thermal analysis method revealed that there is a formation of PEC between chitosan and sodium alginate. In vitro buoyancy and T60%, drug release studies revealed that due to complex formation, formulation remains stable and remains buoyant. From factorial design studies, it was interpreted that for buoyancy time (Y1) chitosan desired effect value was found higher. For 60% drug release (T60%; Y2) both chitosan and sodium alginate have a synergistic effect. Durbin Watson's statistical model and residual data suggested that the model is statistically validated. All formulations follow the zero-order kinetics. Stability studies revealed that formulations F5 and F9 remain stable for long-term stability studies without showing any significant changes. The fit analysis studies indicated that the prepared formulation was different from the innovator product indicating low f1 and f2 values.

Conclusion:
From the result generated it was concluded that chitosan-sodium alginate polyelectrolyte complex has sufficient potential to retard the release of CPT.
Understanding Nucleophilicity of Pyridine-N-oxides Towards
2,4,6-Trinitrophenylbenzoate Through Simple Absorption Spectroscopic
Studies
Authors: Mawrie Ladapborlang , Rahman Fazlur , Gazi Sarifuddin 
Published: August 2023

Aims:
Understanding nucleophilicity of poor nucleophiles like pyridine-N-oxides.

Background:
Nucleophilicity plays a vital role in substitution reactions. It helps to determine the possibility and extent of the substitution reactions. The study of the nucleophilicity of poor nucleophiles is challenging, and it has limited substrate scope. Understanding the strength of nucleophilicity of such poor nucleophiles in a quantitative way is important.

Objective:
Understanding the strength of nucleophilicity of such poor nucleophiles in a quantitative way. Selection of appropriate electrophile for the reactions with the poor nucleophiles-pyridine-N-oxides. Development of suitable methodology for kinetic studies of the reaction.

Methods:
UV-Vis spectroscopic methods for monitoring the reactions.

Results:
The kinetic studies revealed that the second-order rate constants of the nucleophilic reactions are 1.67× 102 L mol-1 min-1, 29.8 L mol-1 min-1, 29.51 L mol-1 min-1, where the nucleophiles are p-methylpyridine-N-oxide, pyridine-N-oxide, and p-nitropyridine-N-oxide, respectively. The UV-Vis spectroscopic analysis revealed the nucleophilicity of p-methylpyridine-N-oxide > pyri-dine-N-oxide > p-nitropyridine-N-oxide.

Conclusion:
This comparative study suggests that the strength of nucleophilicity of the p-methylpyridine-N-oxide is 5.6 times and 66.53 times more than that of pyridine-N-oxide and p-nitropyridine-N-oxide, respectively, whereas the strength of nucleophilicity of the pyridine-N-oxide is 11.87 times more than that of p-nitropyridine-N-oxide.
My Quarantine Diary: A Tool for Self-care and Learning about COVID-19
Authors: da Costa Luana Michelly Aparecida , Aguilar Guilherme José , dos Santos Luiz Ricardo Albano , Lemos Costa Wilbert Dener , de Castro Barros Donato Dantony , Foresto Felipe , Bollela Valdes Roberto , de Oliveira Alan Maicon 
Published: August 2023

Background:
Self-care and self-education are essential for maintaining the health of the population,
mainly in the pandemic scenario as established by COVID-19, where social distancing and avoiding
agglomeration in closed environments is strongly recommended, as well as preventing the spread of
fake news.

Objective:
This study aimed to describe the development and implementation of a self-care and learning
application related to COVID-19.

Methods:
In 2020, right at the beginning of the pandemic, a multidisciplinary team at the University of
São Paulo -Brazil, was formed to develop a technological platform called Meu Diário de Quarentena®
(My Quarantine Diary). In this environment, information on self-care, self-monitoring, and health education
was made available to people facing the challenges of the COVID-19 pandemic. The tools, including
HTML, CSS, PHP, and MySQL database manager, were used.

Results:
Meu Diário de Quarentena® (My Quarantine Diary) platform allowed each person to make their
own assessment and keep a follow-up of signs and symptoms of COVID-19 through a diary that analyzed
the clinical presentation, provided guidance, and suggested an action in real-time to reduce stress and
worries. A diagnostic support algorithm was implemented to mitigate false alarms and highlight the importance
of caring for family members when an infection was suspected. Furthermore, people were
trained with an interactive quiz to promote health education and to offer relevant and updated information
related to the pandemic, which contributed to preventing the spread of fake news.

Conclusion:
A website application (web app) for screening signs and symptoms, self-care, selfmonitoring,
and promoting health education related to the COVID-19 pandemic was developed and made
available on the network. The entire population was given access to Meu Diário de Quarentena® (My
Quarantine Diary).
CONTROLE DISCIPLINAR E BIOPOLÍTICO SOBRE A SEXUALIDADE ATRAVÉS DA TERAPIA DE REVERSÃO DE ORIENTAÇÃO SEXUAL
Authors: Wermuth Maiquel Ângelo Dezordi , Bemfica Melina Macedo 
Published: August 2023

O presente trabalho visa analisar em que medida a sexualidade é disciplinada e normalizada por um discurso supostamente científico, que institui a heterossexualidade como normal e a homossexualidade como patológica, e usa dessa dicotomia para tratar as pessoas homossexuais através de terapias de reversão de orientação sexual. A sexualidade, na medida que representa a intersecção entre indivíduo e população, é controlada através das tecnologias do biopoder. A partir da entrada da sexualidade no discurso científico, ela passa a ser dividida a partir da dicotomia saúde - doença. Apesar da homossexualidade, não ser, do ponto de vista científico, uma enfermidade, esse discurso ainda é usado para exercer controle sobre a sexualidade. Isso pode ser facilmente demostrado através da análise da Reclamação Constitucional 31.818, processo judicial que representou o desfecho de um pedido judicial de psicólogos que buscavam autorização para reverter orientação sexual considerada indesejada.
Eating Behavior and Satiety With Virtual Reality Meals Compared With Real Meals: Randomized Crossover Study
Authors: Glympi Alkyoni , Odegi Dorothy , Zandian Modjtaba , Södersten Per , Bergh Cecilia , Langlet Billy 
Published: August 2023

Background
Eating disorders and obesity are serious health problems with poor treatment outcomes and high relapse rates despite well-established treatments. Several studies have suggested that virtual reality technology could enhance the current treatment outcomes and could be used as an adjunctive tool in their treatment.

Objective
This study aims to investigate the differences between eating virtual and real-life meals and test the hypothesis that eating a virtual meal can reduce hunger among healthy women.

Methods
The study included 20 healthy women and used a randomized crossover design. The participants were asked to eat 1 introduction meal, 2 real meals, and 2 virtual meals, all containing real or virtual meatballs and potatoes. The real meals were eaten on a plate that had been placed on a scale that communicated with analytical software on a computer. The virtual meals were eaten in a room where participants were seated on a real chair in front of a real table and fitted with the virtual reality equipment. The eating behavior for both the real and virtual meals was filmed. Hunger was measured before and after the meals using questionnaires.

Results
There was a significant difference in hunger from baseline to after the real meal (mean difference=61.8, P<.001) but no significant change in hunger from before to after the virtual meal (mean difference=6.9, P=.10). There was no significant difference in food intake between the virtual and real meals (mean difference=36.8, P=.07). Meal duration was significantly shorter in the virtual meal (mean difference=–5.4, P<.001), which led to a higher eating rate (mean difference=82.9, P<.001). Some participants took bites and chewed during the virtual meal, but the number of bites and chews was lower than in the real meal. The meal duration was reduced from the first virtual meal to the second virtual meal, but no significant difference was observed between the 2 real meals.

Conclusions
Eating a virtual meal does not appear to significantly reduce hunger in healthy individuals. Also, this methodology does not significantly result in eating behaviors identical to real-life conditions but does evoke chewing and bite behavior in certain individuals.

Trial Registration
ClinicalTrials.gov NCT05734209, https://clinicaltrials.gov/ct2/show/NCT05734209