bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel quick contrast sensitivity function test in Chinese adults with myopia and its related parameters
Authors: Ye Yuhao , Aruma Aruma , Zhao Wuxiao , Lu Zhong-Lin , Zhou Xingtao , Zhao Jing 
Published: February 2023

Abstract
Purpose
This study is to investigate the contrast sensitivity function (CSF) using the quick CSF (qCSF) test in Chinese adults with myopia.

Methods
This case series study included 320 myopic eyes of 160 patients (mean age 27.75 ± 5.99 years) who underwent a qCSF test for acuity, area under log CSF (AULCSF), and mean contrast sensitivity (CS) at 1.0, 1.5, 3.0, 6.0, 12.0, and 18.0 cycle per degree (cpd). Spherical equivalent, corrected-distant visual acuity (CDVA), and pupil size were recorded.

Results
The spherical equivalent, CDVA (LogMAR), spherical refraction, cylindrical refraction, and the scotopic pupil size of the included eyes were − 6.30 ± 2.27 D (− 14.25 to − 0.88 D), 0 ± 0.02, − 5.74 ± 2.18 D, − 1.11 ± 0.86 D, and 6.77 ± 0.73 mm, respectively. The AULCSF and CSF acuity were 1.01 ± 0.21 and 18.45 ± 5.39 cpd, respectively. The mean CS (log units) at six different spatial frequencies were 1.25 ± 0.14, 1.29 ± 0.14, 1.25 ± 0.14, 0.98 ± 0.26, 0.45 ± 0.28, and 0.13 ± 0.17, respectively. A mixed effect model showed significant correlations between age and acuity, AULCSF, and CSF at 1.0, 12.0, and 18.0 cpd. Interocular CSF differences were correlated with the interocular difference of spherical equivalent, spherical refraction (at 1.0 cpd, 1.5 cpd), and cylindrical refraction (at 12.0 cpd, 18.0 cpd). The lower cylindrical refraction eye had higher CSF compared with the higher cylindrical refraction eye (0.48 ± 0.29 vs. 0.42 ± 0.27 at 12.0 cpd and 0.15 ± 0.19 vs. 0.12 ± 0.15 at 18.0 cpd).

Conclusions
The age-related decrease in contrast sensitivity is at low and high spatial frequencies. Higher-degree myopia may show a decrease in CSF acuity. Low astigmatism was noted to affect the contrast sensitivity significantly.
Air–liquid interface cultures trigger a metabolic shift in intestinal epithelial cells (IPEC-1)
Authors: Stollmeier Martin , Kahlert Stefan , Zuschratter Werner , Oster Michael , Wimmers Klaus , Isermann Berend , Rothkötter Hermann-Josef , Nossol Constanze 
Published: February 2023

Abstract
An improved oxygen availability in air–liquid interface (ALI) cultures of enterocytes of the small intestine seems to be primarily responsible for morphological, metabolic, and functional changes. Intestinal porcine epithelial cells 1 (IPEC-1) are less investigated and are rarely used as model for intestinal barrier but showed a profound change of cell shape during ALI cultivation. We aim to answer the following question: Are the observed morphological effects accompanied by changes in metabolic function? A microarray analysis of submerged culture (SMC) and ALI cultures identified 830 significantly regulated genes. Subsequent functional clustering revealed alterations in 31 pathways, with the highest number of regulated genes in metabolic pathways, carbon metabolism, glycolysis, and hypoxia-inducible factor (HIF) signaling. Furthermore, HIF-1α as a mediator of a metabolic switch between glycolysis and oxidative phosphorylation showed a trend of increased mRNA levels in ALI in contrast to a reduced nuclear HIF-1α content in the nucleus. Candidate genes of oxidative phosphorylation such as a mitochondrial marker exhibited enhanced mRNA levels, which was confirmed by western blot analysis. Cytochrome C oxidase (COX) subunit 5B protein was decreased in ALI, although mRNA level was increased. The oxidation of ferrocytochrome C to ferricytochrome C was used for detection of cytochrome C oxidase activity of isolated mitochondria and resulted in a trend of higher activity in ALI. Furthermore, quantification of glucose and lactate concentrations in cell culture medium revealed significantly reduced glucose levels and decreased lactate production in ALI. To evaluate energy metabolism, we measured cellular adenosine triphosphate (ATP) aggregation in homogenized cell suspensions showing similar levels. However, application of the uncoupling agent FCCP reduced ATP levels in ALI but not in SMC. In contrast, blocking with 2-desoxy-d-glucose (2DG) significantly reduced ATP content in ALI and SMC. These results indicate a metabolic shift in IPEC-1 cultured under ALI conditions enhancing oxidative phosphorylation and suppressing glycolysis.
Perioperative outcomes of robot-assisted versus laparoscopic liver resection for cavernous hemangioma: a propensity score matching study
Authors: Zhang Wei , Liu Junjie , Zhang Zunyi , Wang Yuwei , Xiang Shuai , Chen Lin , Zhu Peng , Zhang Wanguang , Shu Chang , Lau Wan Yee , Zhang Bixiang , Chen Xiaoping 
Published: February 2023

Abstract
Background
Minimally invasive techniques have increasingly been adopted for liver resection. This study aimed to compare the perioperative outcomes of robot-assisted liver resection (RALR) with laparoscopic liver resection (LLR) for liver cavernous hemangioma and to evaluate the treatment feasibility and safety.

Methods
A retrospective study of prospectively collected data was conducted on consecutive patients who underwent RALR (n = 43) and LLR (n = 244) for liver cavernous hemangioma between February 2015 and June 2021 at our institution. Patient demographics, tumor characteristics, and intraoperative and postoperative outcomes were analyzed and compared using propensity score matching.

Results
The postoperative hospital stay was significantly shorter (P = 0.016) in the RALR group. There were no significant differences between the two groups in overall operative time, intraoperative blood loss, blood transfusion rates, conversion to open surgery or complication rates. There was no perioperative mortality. Multivariate analysis showed that hemangiomas located in posterosuperior liver segments and those in close proximity to major vascular structures were independent predictors of increased intraoperative blood loss (P = 0.013 and P = 0.001, respectively). For patients with hemangioma in close proximity to major vascular structures, there were no significant differences in perioperative outcomes between the two groups, with the exception that intraoperative blood loss in the RALR group was significantly less than that in the LLR group (350 ml vs. 450 ml, P = 0.044).

Conclusions
Both RALR and LLR were safe and feasible for treating liver hemangioma in well-selected patients. For patients with liver hemangioma in close proximity to major vascular structures, RALR was better than conventional laparoscopic surgery in reducing intraoperative blood loss.
Neural architecture search for energy-efficient always-on audio machine learning
Authors: Speckhard Daniel T. , Misiunas Karolis , Perel Sagi , Zhu Tenghui , Carlile Simon , Slaney Malcolm 
Published: February 2023

AbstractMobile and edge computing devices for always-on classification tasks require energy-efficient neural network architectures. In this paper we present several changes to neural architecture searches that improve the chance of success in practical situations. Our search simultaneously optimizes for network accuracy, energy efficiency and memory usage. We benchmark the performance of our search on real hardware, but since running thousands of tests with real hardware is difficult, we use a random forest model to roughly predict the energy usage of a candidate network. We present a search strategy that uses both Bayesian and regularized evolutionary search with particle swarms, and employs early stopping to reduce the computational burden. Our search, evaluated on a sound event classification dataset based upon AudioSet, results in an order of magnitude less energy per inference and a much smaller memory footprint than our baseline MobileNetV1/V2 implementations while slightly improving task accuracy. We also demonstrate how combining a 2D spectrogram with a convolution with many filters causes a computational bottleneck for audio classification and that alternative approaches reduce the computational burden but sacrifice task accuracy.
Optimised endoscopic access for intrajejunal levodopa application in idiopathic Parkinson's syndrome
Authors: Grund K. E. , Zipfel A. , Duckworth-Mothes B. , Jost W. H. 
Published: February 2023

AbstractPump-guided intrajejunal levodopa administration is one of the indispensable forms of therapy in advanced Parkinson's syndrome, along with deep brain stimulation and subcutaneous apomorphine injection. The standard application of levodopa gel via a JET-PEG, i.e. a percutaneous endoscopic gastrostomy (PEG) with an inserted internal catheter into the jejunum, has not been unproblematic due to the restricted absorption area of the drug in the region of the flexura duodenojejunalis and especially due to the sometimes considerable accumulated complication rates of a JET-PEG. Causes of complications are mainly a non-optimal application technique of PEG and internal catheter as well as the often missing adequate follow-up care. This article presents the details of a—compared to the conventional technique—modified and optimised application technique, which has been clinically proven successfully for years. However, many details derived from anatomical, physiological, surgical and endoscopic aspects must be strictly observed during the application to reduce or avoid minor and major complications. Local infections and buried bumper syndrome cause particular problems. The relatively frequent dislocations of the internal catheter (which can ultimately be avoided by clip-fixing the catheter tip) also prove to be particularly troublesome. Finally, using the Hybrid technique, a new combination of an endoscopically controlled gastropexy with 3 sutures and subsequent central thread pull-through (TPT) of the PEG tube, the complication rate can be dramatically reduced and thus a decisive improvement achieved for patients. The aspects discussed here are highly relevant for all those involved in the therapy of advanced Parkinson's syndrome.
Novel object recognition in Octopus maya
Authors: Vergara-Ovalle Fabian , Ayala-Guerrero Fructuoso , Rosas Carlos , Sánchez-Castillo Hugo 
Published: February 2023

AbstractThe Novel Object Recognition task (NOR) is widely used to study vertebrates' memory. It has been proposed as an adequate model for studying memory in different taxonomic groups, allowing similar and comparable results. Although in cephalopods, several research reports could indicate that they recognize objects in their environment, it has not been tested as an experimental paradigm that allows studying different memory phases. This study shows that two-month-old and older Octopus maya subjects can differentiate between a new object and a known one, but one-month-old subjects cannot. Furthermore, we observed that octopuses use vision and tactile exploration of new objects to achieve object recognition, while familiar objects only need to be explored visually. To our knowledge, this is the first time showing an invertebrate performing the NOR task similarly to how it is performed in vertebrates. These results establish a guide to studying object recognition memory in octopuses and the ontological development of that memory.
A simple and fast linear-time algorithm for divisor methods of apportionment
Authors: Reitzig Raphael , Wild Sebastian 
Published: February 2023

AbstractProportional apportionment is the problem of assigning seats to states (resp. parties) according to their relative share of the population (resp. votes), a field heavily influenced by the early work of Michel Balinski, not least his influential 1982 book with Peyton Young (Fair representation, 2nd edn. Brookings Institution Press, Washington, D.C., 2001). In this article, we consider the computational cost of divisor methods (also known as highest averages methods), the de-facto standard solution that is used in many countries. We show that a simple linear-time algorithm can exactly simulate all instances of the family of divisor methods of apportionment by reducing the problem to a single call to a selection algorithm. All previously published solutions were iterative methods that either offer no linear-time guarantee in the worst case or require a complex update step that suffers from numerical instability.
Influence of combined aging on the mechanical and physical properties of reclaimed asphalt pavement mixtures blended with rejuvenator agents
Authors: Iwama Masahiko , Hayano Kimitoshi 
Published: February 2023

AbstractRecently, reclaimed asphalt pavement (RAP) with high RAP contents with rejuvenator agents have been implemented in Japan. However, a unified view of the durability of RAP mixtures with rejuvenators has not been established. Therefore, this paper aims to assess the durability of RAP mixtures blended with different types of rejuvenators through combined aging, compared with that of hot mixed asphalt (HMA) mixture. Mechanical and physical properties of RAP mixtures with rejuvenators subjected to a combination of moisture, heat, and oxidation were investigated. Saturation aging tensile stiffness conditioning was used to simulate the combined aging. Four types of RAP mixtures were prepared by employing two types of oil-based rejuvenators with two RAP contents. HMA mixtures were also prepared. The test results demonstrated that the RAP mixtures did not exhibit a reduction in the retained stiffness, whereas the HMA mixtures exhibited a significant drop in stiffness with conditioning. In addition, the RAP mixtures exhibited a longer residual service life than the HMA mixtures after conditioning. Detailed analyses revealed differences in the stiffness and fatigue behaviors of the RAP mixtures with different types of rejuvenators. Finally, certain aspects of the deterioration mechanisms of RAP mixtures with rejuvenators were discussed.
‘System friction’ in China-EU economic relations and the reaction of the EU
Authors: Voogsgeerd Herman 
Published: February 2023

AbstractIn the period between 2015 and 2020, we have witnessed an increase in ‘system friction’ in the trade and investment relations between the EU and the People’s Republic of China (PRC). This paper focuses on the meaning of this notion of ‘system friction’, originally coined by Sylvia Ostry and on how the EU and especially the European Commission reacted to this friction. This notion might present an alternative to the notion of ‘system rivalry’. The result of system friction in the relation between the EU and the PRC had been a convergence towards more trade defensive moves. A form of managed trade with help of a ratified Investment treaty between the two sides might be a potential outcome.
Internet usage among the oldest-old: does functional health moderate the relationship between internet usage and autonomy?
Authors: Oswald Veronica , Wagner Michael 
Published: February 2023

AbstractIn recent years, research on internet usage in old age and its associations with well-being outcomes has increased. However, the oldest-old age group (80 years and older) is frequently underrepresented, and autonomy and functional health are rarely considered in these studies. By applying moderation analyses with a representative dataset of the oldest-old in Germany (N = 1863), our study has analyzed the hypothesis that the autonomy of older individuals, in particular of those with limited functional health, can be enhanced by internet usage. The moderation analyses indicate that the positive association between internet usage and autonomy is greater for older individuals with lower functional health. This association remained significant after controlling for social support, housing situation, education, gender, and age. Explanations for these results are discussed, and imply that further research is needed to understand the relationships between internet usage, functional health, and autonomy.
Tuning the Microenvironment to Create Functionally Distinct Mesenchymal Stromal Cell Spheroids
Authors: Thai Victoria L. , Candelas Diego O. , Leach J. Kent 
Published: February 2023

AbstractMesenchymal stromal cells (MSCs) are under investigation for wound healing and tissue regeneration due to their potent secretome. Compared to monodisperse cells, MSC spheroids exhibit increased cell survival and enhanced secretion of endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2), two key factors in wound repair. We previously upregulated the proangiogenic potential of homotypic MSC spheroids by manipulating microenvironmental culture conditions. However, this approach depends on the responsiveness of host endothelial cells (ECs)—a limitation when attempting to restore large tissue deficits and for patients with chronic wounds in which ECs are dysfunctional and unresponsive. To address this challenge, we used a Design of Experiments (DOE) approach to engineer functionally distinct MSC spheroids that maximize VEGF production (VEGFMAX) or PGE2 production (PGE2,MAX) while incorporating ECs that could serve as the basic building blocks for vessel formation. VEGFMAX produced 22.7-fold more VEGF with enhanced endothelial cell migration compared to PGE2,MAX, while PGE2,MAX produced 16.7-fold more PGE2 with accelerated keratinocyte migration compared to VEGFMAX. When encapsulated together in engineered protease-degradable hydrogels as a model of cell delivery, VEGFMAX and PGE2,MAX spheroids exhibited robust spreading into the biomaterial and enhanced metabolic activity. The distinct bioactivities of these MSC spheroids demonstrate the highly tunable nature of spheroids and provide a new approach to leverage the therapeutic potential of cell-based therapies.
Landscape genetics identifies barriers to Natterjack toad metapopulation dispersal
Authors: Reyne Marina I. , Dicks Kara , Flanagan Jason , Nolan Paul , Twining Joshua P. , Aubry Aurélie , Emmerson Mark , Marnell Ferdia , Helyar Sarah , Reid Neil 
Published: February 2023

AbstractHabitat fragmentation and loss reduce population size and connectivity, which imperils populations. Functional connectivity is key for species persistence in human-modified landscapes. To inform species conservation management, we investigated spatial genetic structure, gene flow and inferred dispersal between twelve breeding sites of the Natterjack toad (Bufo calamita); regionally Red-Listed as Endangered in Ireland. Spatial genetic structure was determined using both Bayesian and non-Bayesian clustering analysis of 13 polymorphic microsatellite loci genotyping 247 individuals. We tested the influence of geographic distance, climate, habitat, geographical features, and anthropogenic pressure on pairwise genetic distances between breeding sites using Isolation-by-distance and Isolation-by-resistance based on least-cost path and circuit theory models of functional connectivity. There was clear spatial structuring with genetic distances increasing with geographic distance. Gene flow was best explained by Isolation-by-resistance models with coniferous forestry plantations, bog, marsh, moor and heath, scrub, anthropogenic presence (Human Influence Index) and rivers (riparian density) identified as habitats with high resistance to gene flow while metapopulation connectivity was enhanced by coastal habitats (beaches, sand dunes and salt marshes) and coastal grassland. Despite substantial declines in census numbers over the past 15 years and its regional status as Endangered, the Natterjack toad population in Ireland retains high genetic diversity. If declines continue, maintaining habitat connectivity to prevent genetic erosion by management of coastal grasslands, pond construction and assisted migration through translocation will be increasingly important.
Marginal Damage of Methane Emissions: Ozone Impacts on Agriculture
Authors: Sampedro Jon , Waldhoff Stephanie , Sarofim Marcus , Van Dingenen Rita 
Published: February 2023

AbstractMethane directly contributes to air pollution, as an ozone precursor, and to climate change, generating physical and economic damages to different systems, namely agriculture, vegetation, energy, human health, or biodiversity. The methane-related damages to climate, measured as the Social Cost of Methane, and to human health have been analyzed by different studies and considered by government rulemaking in the last decades, but the ozone-related damages to crop revenues associated to methane emissions have not been incorporated to policy agenda. Using a combination of the Global Change Analysis Model and the TM5-FASST Scenario Screening Tool, we estimate that global marginal agricultural damages range from ~ 423 to 556 $2010/t-CH4, of which 98 $2010/t-CH4 occur in the USA, which is the most affected region due to its role as a major crop producer, followed by China, EU-15, and India. These damages would represent 39–59% of the climate damages and 28–64% of the human health damages associated with methane emissions by previous studies. The marginal damages to crop revenues calculated in this study complement the damages from methane to climate and human health, and provides valuable information to be considered in future cost-benefits analyses.
Double Disadvantage in a Nordic Welfare State: A Demographic Analysis of the Single-Parent Employment Gap in Finland, 1987–2018
Authors: Härkönen Juho , Jalovaara Marika , Lappalainen Eevi , Miettinen Anneli 
Published: February 2023

AbstractThis study demonstrates how an evolving negative educational gradient of single parenthood can interact with changing labour market conditions to shape labour market inequalities between partnered and single parents. We analysed trends in employment rates among Finnish partnered and single mothers and fathers from 1987 to 2018. In the late 1980s’ Finland, single mothers’ employment was internationally high and on par with that of partnered mothers, and single fathers’ employment rate was just below that of partnered fathers. The gaps between single and partnered parents emerged and increased during the 1990s recession, and after the 2008 economic crisis, it widened further. In 2018, the employment rates of single parents were 11–12 percentage points lower than those of partnered parents. We ask how much of this single-parent employment gap could be explained by compositional factors, and the widening educational gradient of single parenthood in particular. We use Chevan and Sutherland’s decomposition technique on register data, which allows us to decompose the single-parent employment gap into the composition and rate effects by each category of the background variables. The findings point to an increasing double disadvantage of single parents: the gradually evolving disadvantage in educational backgrounds together with large differences in employment rates between single and partnered parents with low education explain large parts of the widening employment gap. Sociodemographic changes in interaction with changes in the labour market can produce inequalities by family structure in a Nordic society known for its extensive support for combining childcare and employment for all parents.