bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.
Authors: Wu Haotian , Kalia Vrinda , Manz Katherine E. , Chillrud Lawrence , Dishon Nathalie Hoffman , Jackson Gabriela L. , Dye Christian K. , Orvieto Raoul , Aizer Adva , Levine Hagai , Kioumourtzoglou Marianthi-Anna , Pennell Kurt D. , Baccarelli Andrea A. , Machtinger Ronit 
Published: June 2023

Abstract

There is evidence that indicators of male fertility are in decline globally, but the underlying causes to this pressing global concern have yet to be elucidated. While environmental chemicals are likely major contributors, current knowledge of environmental determinants of male fertility is limited and does not adequately explain this phenomenon. Previous studies have typically examined only limited sets of exposures in blood or urine, which may not accurately capture chemical burden in relevant reproductive tissues, and have overlooked a large range of potential concurrent exposures. Here, using an expansive non-targeted analysis to profile the exposome, we detected widespread environmental pollutant exposure from common and rare environmental exposures in seminal plasma. Machine learning pattern recognition and mixture models identified Etridiazole and N-nitrosodiethylamine to be negatively associated with semen parameters. Our findings suggest that these chemicals are detrimental to sperm and exposomic studies can be used to identify potential reproductive toxicants.
ANALISIS KEGIATAN PEMELIHARAAN MESIN DAN BANGUNAN PADA PABRIK TAHU UNTUK MEMINIMUMKAN BIAYA SAAT PANDEMI COVID-19
Authors: Widat Shafwil Widat , Awalina Devita Nur , Mufidah Kiki Maulia 
Published: June 2023

Salah satu kegiatan yang dilakukan dalam menanggulangi produksi yang berangsur secara terus menerus maka perlu dilakukannya pemeliharaan mesin. untuk mencapai laba yang maksimal. maka perusahaan harus mempunyai cara yang tepat dengan cara megendalikan biaya untuk keperluaan produksi.Tujuan dari penelitian untuk menjelaskan bagaimana menganalisis pemeliharaan mesin dalam meminimumkan biaya pemeliharaan pada masa pandemi di Pabrik tahu Mahmud Putra. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yaitu wawancara lagsung dengan pihak berkepentingan. Kerusakan mesin yang sering terjadi di Pabrik tahu Mahmud Putra ialah pada mesin penggiling kedelai lebih tepatnya pada batu dan laher. Untuk mengatasinya dilakukan pemeliharaan pencegahan dan pemeliharaan perbaikan.
Pengaruh Current Ratio (CR), Net Profit Margin (NPM), Total Asset Turn Over (TATO) Terhadap Profitabilitas Perusahaan PT. Telkom Indonesia Tahun 2011-2020
Authors: Nadila Ayva , Hapsari Mega Tunjung 
Published: June 2023

Dalam sebuah perusahaan sangatlah penting adanya profit karena profit merupakan tingkat efisiensi perusahaan, yaitu sejauh mana kemampuan perusahaan untuk mengurangi biaya operasi selama periode waktu tertentu. Dengan adanya profit investor akan mengetahui seberapa perusahaan tersebut mampu menghasilkan laba, sehingga investor dapat mengambil keputusan dengan bijak. Dan investor tidak akan merasa rugi berinvestasi di perusahaan tersebut. Seorang investor hanya perlu melakukan sebuah analisa yang mempengaruhi adanya profit. Penelitian ini bertujuan untuk mengetahui Pengaruh Current Ratio (CR), Net Profit Margin (NPM), Total Asset Turn Over (TATO) Terhadap Profitabilitas (Return On Asset) pada perusahaan PT. Telkom Indonesia pada tahun 2011-2020. Penelitian ini menggunakan pendekatan metode kuantitatif dengan data sekunder yang diperoleh dari dokumen data laporan keuangan perusahaan dengan teknik dokumentasi melalui media internet dan aplikasi Indopremier sekuritas. Teknik analisis data yang digunakan adalah uji asumsi klasik, regresi linier berganda, uji hipotesis, serta koefisien determinan. Pengolahan data menggunakan program software SPSS (Statistic Package for the Social Sciens) 25.0 for windows. Hasil penelitian ini membuktikan bahwa variabel Current Ratio (CR) tidak berpengaruh positif dan signifikan terhadap Return On Asset (ROA) pada tahun 2011-2020. Sedangkan variabel Net Profit Margin (NPM) dan Total Asset Turn Over (TATO) berpengaruh positif dan signifikan terhadap Return On Asset (ROA) pada tahun 2011-2020.
ANALISIS SWOT DALAM MENENTUKAN STRATEGI PEMASARAN TELUR AYAM RAS DI UD. JAYA MAKMUR DESA BENDOSARI BLITAR
Authors: Ariska Hilmi , Pravitasari Dyah 
Published: June 2023

Sektor peternakan ayam petelur merupakan salah satu sektor pokok bagi kebutuhan manusia. Permasalahan-permasalahan yang timbul mulai dari proses produksi telur hingga pemasaran telur tentu saja perlu dianalisis dan ditangani secara serius, sehingga nantinya mampu memberikan banyak manfaat bagi sektor kebutuhan pokok dan sektor perekonomian masyarakat secara umum. Tujuan penelitian ini adalah 1) mengidentifikasi IFAS dan EFAS; dan 2) melakukan analisis SWOT untuk menentukan strategi pemasaran pada UD. Jaya Makmur Desa Bendosari Blitar. Pendekatan dalam penelitian ini adalah pendekatan kualitatif, dengan metode deskriptif. Peneliti bertindak sebagai instrumen sekaligus pengumpul data. Data primer dalam penelitian ini diperoleh peneliti berdasarkan wawancara kepada subjek penelitian. Penelitian ini dilakukan di UD. Jaya Makmur dengan pemilik Ibu Nur Hidayati yang berlokasi di Desa Bendosari Blitar. Setelah dilakukan analisis menggunakan matriks internal faktor (IFAS) dan eksternal faktor (EFAS) ditemukan hasil bahwa strategi pemasaran UD Jaya Makmur memperoleh nilai 3,33 dan 3,66. Hal ini menunjukkan bahwa UD Jaya Makmur berada pada titik koordinat (0,55: 0,43) yang terletak pada kuadran I (agresif) di antara kekuatan dan ancaman, sehingga yang digunakan yaitu strategi SO. Strategi yang dapat digunakan antara lain melakukan pengembangan dan promosi produk unggulan pada media online selain pada WhatsApp, Facebook, Instagram, dan lain-lain; melakukan pendekatan dan peningkatan kualitas agar masyarakat tetap percaya; peningkatan sistem pembayaran di akhir; peningkatan seleksi telur ayam agar pelanggan tetap loyal; serta memberikan wawasan bagi pelaku usaha dengan bahan baku telur agar UD Jaya makmur dan pemilik usaha sama-sama berkembang.
DESCRIPTION OF PAIN IN DIABETES MELLITUS AND NON-DIABETES MELLITUS PATIENTS AT PUSKESMAS DANUREJAN 1, YOGYAKARTA
Authors: Wibowo Anandora Bagas Satrio , Sari Lisa Kurnia , Lestari MMA Dewi , Sp.PD Dr. Probosuseno , Suryanto Yanti Ivana 
Published: June 2023

<p><strong>Background</strong> Diabetes mellitus (DM) is a disease caused by impaired glucose metabolism, failure of the pancreas to produce the insulin hormone or the body's inability to respond to the insulin hormone. The neurologic complications are neuropathic or nociceptive pain. Neuropathic pain can cause the decrease in patient’s quality of life. Knowing the spread of neuropathic pain based on anatomical predilection may help clinicians conduct early diagnosis and improve the patient's quality of life.</p><p><strong>Objective</strong> This study aim to determine the characteristics, prevalence and location of pain in patients with type 2 diabetes mellitus and non-diabetes mellitus at Puskesmas Danurejan I Yogyakarta.</p><p><strong>Methods</strong> A descriptive quantitative study on 42 secondary data from previous study in Puskesmas Danurejan I. The inclusion criteria were data of patients with neuropathic pain (electric shock-like pain, stabbing pain) and nociceptive pain (burning sensation pain) who were &gt; 40 years old. The exclusion criteria were incomplete data and recorded consumed non-steroidal anti-inflammatory drugs in the last of 4 days in previous study. Univariate and bivariate analysis were used in this study.</p><p><strong>Results</strong> Patients with DM accounted for 50% of cases by 21 people. Patients with DM had the most frequent comorbidities, such as hypertension (42.8%) and obesity (42.8%), Most patients with DM reported pain (85.7%) with neuropathic back pain (27.7%). Based on the type of pain, patients with DM most frequently reported neuropathic pain (66.7%) (p=0.001).</p><p><strong>Conclusion</strong> There was a relationship between diabetes mellitus and the incidence of neuropatic pain but not nociceptive pain.</p>
Comparative evaluation of preventive anticoagulant therapy regimens in the wounded
Authors: Varavin N. A. , Salukhov V. V. , Kryukov E. V. , Kolodyazhnaya V. A. 
Published: June 2023

Introduction. Currently, the issues of prescribing anticoagulant therapy to the wounded are poorly studied, the doses of drugs and the timing of its implementation have not been determined.Aim. To study various modes of anticoagulant therapy for the prevention of venous thrombosis of the lower extremities in the wounded after surgery using the parameters of the plasma hemostasis system and the Thrombodynamics test.Materials and methods. A prospective study was conducted, which included 90 wounded with mine-explosive/gunshot injury receiving anticoagulant therapy in preventive doses. The studies were carried out on the equipment of the Thrombodynamics recorder (HemaCor, Moscow). The patients were divided into 3 groups: 1 group, which included 30 patients taking rivaroxaban at a dose of 10 mg/day, 2 group of 30 patients receiving enoxaparin sodium at a dose of 40 mg once a day, 3 group consisting of 30 patients receiving enoxaparin sodium 40 mg 2 times a day. In the dynamics of treatment, the parameters of the plasma hemostasis system and the parameters of the Thrombodynamics test were evaluated.Results. It was revealed that during preventive anticoagulant therapy, there were no significant differences in the standard parameters of the coagulogram, when studying the parameters of the Thrombodynamics test, significant differences wereobserved between groups 1 and 3 in values (V/VSt, Vi, Tlag, СS), between group 2 and 3 in parameter (V/VSt, Vi, Tlag, СS), between group 1 and group 2 in the value of D. A statistically significant relationship was found between the Thrombodynamics parameter D and the indicators of TV, prothrombin by Quick, and fibrinogen content.Conclusion. The Thrombodynamics test can be used as a potential tool for a personalized approach to monitoring the hemostasis system in the wounded.
A institucionalização situada do Polo Industrial e Tecnológico em Saúde de Eusébio, Ceará
Authors: Freire Bruna Gonçalves de Oliveira , Ipiranga Ana Silvia Rocha 
Published: June 2023

RecentementeRecentemente foi reconhecida, na teoria institucional, a questão da dinâmica espaço-temporal dos processos institucionais e a sua influência em territórios delimitados. Com base no conceito de institucionalismo situado, esse estudo problematizou o caso do Polo Industrial e Tecnológico da Saúde (PITS), localizado na cidade do Eusébio, que tem entre os seus objetivos desenvolver o setor da saúde do Estado do Ceará. O objetivo do artigo foi compreender o processo de institucionalização do PITS. Tendo como questão guia: o processo de institucionalização do PITS, localizado na cidade de Eusébio, ocorre de forma situada? A metodologia baseou-se na estratégia do estudo de caso qualitativo. Além disso, uma pesquisa documental com levantamentos de materiais e a constituição de um acervo da pesquisa foi efetuada. Para a análise foram selecionadas as “pistas documentais”, a fim de estabelecer as ligações, as comparações e a constituição de configurações significativas entre os elementos e as dimensões pertinentes dos textos documentais com o objetivo da pesquisa. Por um lado, os resultados evidenciaram que, nesta fase de implementação, o processo de institucionalização do PITS se pautou mais pelo tradicional modelo das políticas regionais; e menos pela organização de práticas institucionais situadas no sentido de mobilizar uma rede de atores que conecte pessoas, cotidianos e organizações entre diferentes lugares, tanto na cidade do Eusébio, como na cidade vizinha, Fortaleza. Contudo, no caso do PITS esta concepção de organização em alusão ao espaço estabeleceu um nível de análise que permitirá a consideração e o aprofundamento desses processos microssociais em estudos futuros.
Application of system dynamics model for reservoir performance under future climatic scenarios in Gelevard Dam, Iran
Authors: Babolhakami Ali , Gholami Sefidkouhi Mohammad Ali , Emadi Alireza 
Published: June 2023

Abstract

This study aimed to investigate the effects of climate change scenarios on five indicators: reliability, vulnerability, resilience, sustainability, and the deficiency of the Gelevard Dam (GD) in Iran. Downscaling was performed from 2020 to 2040 in the future using the Can Ems2-GCM based on different climate scenarios and employing the support vector machines. The IHACRES model was used to simulate the inflow of GD. The cultivation pattern optimization function was performed by utilizing the LINGO software. Similarly, the flow-storage model was created using Vensim software. The results demonstrated the reduction of inflow by 15, 36, and 37% during RCP2.6, RCP4.5, and RCP8.5 scenarios, respectively. The results showed that if the optimal cultivation pattern (OCP) were to be applied, during different climatic scenarios, water supply would not be difficult in the next 11, 5, and 4 years, respectively, yet after that, water shortage would gradually appear. The findings concluded that although the implementation of OCP would improve the five indicators in all water consumption sectors, the GD reservoir would not be able to answer the demands in the future. Therefore, it would be necessary to implement practices to increase water productivity in all sectors.
Probabilistic analysis on the influences of heatwaves during the onset of flash droughts over China
Authors: Zhang Xinyu , Liu Yi , Zhu Ye , Ma Qiang , Philippe Gourbesville , Qu Yanping , Yin Hang 
Published: June 2023

Abstract

The increasing concurrences of heatwaves and droughts in the context of global warming have attracted much attention from the scientific community given their devastating social and environmental impacts. In this study, the effects of heatwaves in each adjacent week of flash drought onset on the intensification rate of soil moisture were quantified through a meta-Gaussian-based conditional probability model. Results showed that both heatwaves and flash droughts have become more frequent since the middle of the 1990s. For the seasonal distributions, except for the southwestern region where flash droughts lagged behind heatwaves, there was a good synchronization between the two climate extremes. Strong correlations between heatwaves and flash droughts were found in the northeastern, northern, and southwestern regions. Heatwaves with varied timing of emergence behave differently on the formation of flash droughts, along with significant regional differences. Short-term impending hot conditions were crucial for the breakout of flash droughts, especially for the week when flash droughts were initiated, the emergence of heatwaves was likely to increase the intensification rate of soil moisture by 20% compared to those with no heatwaves in their development stage.
Perspectives and prospects of chelation extraction of heavy metals from wastewater: A review
Authors: Nyamato George Simba 
Published: June 2023

Abstract
Heavy metals' contamination of water resources is a global environmental issue due to their detrimental effects on human health. To safeguard humans and the environment, toxic heavy metals must be removed from contaminated water because they cannot be broken down. Diverse technologies are employed to reduce the levels of heavy metals in wastewater. However, these technologies suffer from being either costly or ineffective, particularly when the effluent has extremely low residual amounts. This review outlines the main accomplishments and promising future directions for solvent extraction as one of the potential methods of extracting heavy metals from water, utilizing literature reports. In addition to reviewing some of the commercial chelating reagents now in use, this article also discusses some of the obnoxious effects on human health that are associated with exposure to heavy metals.
Scorpion Venom Component; BmK AGAP Potentiates the Analgesic
Effects of Lidocaine During Sciatic Nerve Block
Authors: Kampo Sylvanus , Anabah Thomas Winsum , Bayor Fidelis , Wilfred Sam-Awortwi 
Published: June 2023

Background:
Various analgesic adjuvants, including opioids, have been tested and demon-strated to be clinically beneficial when added to local anesthetics to increase the duration of analgesia with the risk of various adverse effects. This study was designed to test the hypothesis that a scorpion venom component, BmK AGAP, may have a synergistic effect with lidocaine.

Methods:
We performed partial sciatic nerve ligation on 84 rats to induce a rapid onset and long-lasting mechanical allodynia. An equal volume (600μl) of lidocaine and BmK AGAP were prepared with saline. The rats were randomly assigned to one of seven groups. Group A (n = 12) received saline as the control; Group B (n = 12) received lidocaine alone; Group C (n = 12) received BmK AGAP alone; Group D, E, F and G (n = 12 each) received lidocaine and different concentrations of BmK AGAP combined. The von Frey filaments were used to assess mechanical allodynia in the rats.

Results:
We observed a decrease in pain intensity and a prolonged duration of analgesia in rats that received BmK AGAP with lidocaine.

Conclusion:
BmK AGAP with lidocaine decreased pain intensity and increased the duration of analgesia.
Using Patient Blogs on Social Media to Assess the Content Validity of Patient-Reported Outcome Measures: Qualitative Analysis of Patient-Written Blogs
Authors: Delnoij Diana M J , Derks Meggie , Koolen Laura , Shekary Shuka , Suitela Jozua 
Published: June 2023

Background
Patient-reported outcome measures (PROMs) are questionnaires that measure patient outcomes related to quality of life, health, and functioning, and are increasingly used to assess important outcomes from the patient’s perspective. For PROMs to contribute to better health and better care, it is vital that their content validity be adequate. This requires patient involvement in various steps of PROM development. PROM developers not only recognize the benefits of patient involvement but also report difficulties in recruiting patients and experience patient involvement as time-consuming, logistically challenging, and expensive.

Objective
This study seeks to explore different strategies for disclosing the experiential knowledge of patients, namely through analyzing patient stories on the web and social media. The research questions are as follows: (1) how do bloggers living with a disease experience their health-related quality of life? (2) How are these experiences reflected in the domains and items of PROMs related to their disease?

Methods
First, a qualitative analysis of blogs written by patients was performed. Second, subthemes and underlying codes resulting from this qualitative analysis were systematically compared with the domains and items in PROMs for the respective diseases that the bloggers write about. Blogs were identified via the Google search engine between December 2019 and May 2021.

Results
Bloggers describe a wide range of experiences regarding their physical functioning and health; mental well-being; social network and support; daily life, education, work, and leisure; coping; and self-management. Bloggers also write about their positive and negative experiences with health care delivery, the organization of health care, and health care professionals. In general, patients’ experiences as described in blogs were reflected in the domains and items of the PROMs related to their disease. However, except for diabetes mellitus, in all the sets of PROMs, potentially missing topics could be identified. Similarly, with the exception of Parkinson disease, all PROMs address issues that patients did not write about in their blogs and that might therefore be redundant.

Conclusions
Web-based patient stories in the form of blogs reveal how people living with a certain disease experience their health-related quality of life. These stories enable analyses of patients’ experiences that can be used to assess the content validity of PROMs. This can be a useful step for researchers who are looking for sets of measuring instruments that match their purposes.
Assessing How Risk Communication Surveillance Prompts COVID-19 Vaccine Acceptance Among Internet Users by Applying the Situational Theory of Problem Solving: Cross-Sectional Study
Authors: Jin Qiang , Raza Syed Hassan , Yousaf Muhammad , Zaman Umer , Ogadimma Emenyeonu C , Shah Amjad Ali , Core Rachel , Malik Aqdas 
Published: June 2023

Background
The World Health Organization has recently raised concerns regarding the low number of people fully vaccinated against COVID-19. The low ratio of fully vaccinated people and the emergence of renewed infectious variants correspond to worsening public health. Global health managers have highlighted COVID-19 vaccine–related infodemics as a significant risk perception factor hindering mass vaccination campaigns.

Objective
Given the ambiguous digital communication environment that has fostered infodemics, resource-limited nations struggle to boost public willingness to encourage people to fully vaccinate. Authorities have launched some risk communication–laden digital interventions in response to infodemics. However, the value of the risk communication strategies used to tackle infodemics needs to be evaluated. The current research using the tenets of the Situational Theory of Problem Solving is novel, as it explores the impending effects of risk communication strategies. The relationship between infodemic-induced risk perception of COVID-19 vaccine safety and risk communication actions to intensify willingness to be fully vaccinated was examined.

Methods
This study used a cross-sectional research design vis-à-vis a nationally representative web-based survey. We collected data from 1946 internet users across Pakistan. Participants voluntarily participated in this research after completing the consent form and reading ethical permissions. Responses were received over 3 months, from May 2022 to July 2022.

Results
The results delineated that infodemics positively affected risk perception. This realization pushed the public to engage in risky communicative actions through reliance on and searches for accurate information. Therefore, the prospect of managing infodemics through risk information exposure (eg, digital interventions) using the situational context could predict robust willingness to be fully vaccinated against COVID-19.

Conclusions
These pioneering results offer strategic considerations for health authorities to effectively manage the descending spiral of optimal protection against COVID-19. This research concludes that the likelihood of managing infodemics using situational context through exposure to relevant information could improve one’s knowledge of forfending and selection, which can lead to robust protection against COVID-19. Hence, more situation-specific information about the underlying problem (ie, the selection of an appropriate vaccine) can be made accessible through several official digital sources to achieve a more active public health response.