bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare-earth control of phase transitions in infinite-layer nickelates
Authors: Zhang Yajun , Zhang Jingtong , He Xu , Wang Jie , Ghosez Philippe 
Published: March 2023

Abstract
Perovskite nickelates RNiO3 (R = rare-earth ion) exhibit complex rare-earth ion dependent phase diagram and high tunability of various appealing properties. Here, combining first- and finite-temperature second-principles calculations, we explicitly demonstrate that the superior merits of the interplay among lattice, electron, and spin degrees of freedom can be passed to RNiO2, which recently gained significant interest as superconductors. We unveil that decreasing the rare-earth size directly modulates the structural, electronic, and magnetic properties and naturally groups infinite-layer nickelates into two categories in terms of the Fermi surface and magnetic dimensionality: compounds with large rare-earth sizes (La, Pr) closely resemble the key properties of CaCuO2, showing quasi-two-dimensional (2D) antiferromagnetic (AFM) correlations and strongly localized dx2−y2 orbitals around the Fermi level; the compounds with small rare-earth sizes (Nd–Lu) are highly analogous to ferropnictides, showing three-dimensional (3D) magnetic dimensionality and strong kz dispersion of d3z2−r2 electrons at the Fermi level. Additionally, we highlight that RNiO2 with R = Nd–Lu exhibit on cooling a structural transition with the appearance of oxygen rotation motion, which is softened by the reduction of rare-earth size and enhanced by spin-rotation couplings. The rare-earth control of kz dispersion and structural phase transition might be the key factors differentiating the distinct upper critical field and resistivity in different compounds. The established original phase diagram summarizing the temperature and rare-earth controlled structural, electronic, and magnetic transitions in RNiO2 compounds provides rich structural and chemical flexibility to tailor the superconducting property.
mHealth hyperspectral learning for instantaneous spatiospectral imaging of hemodynamics
Authors: Ji Yuhyun , Park Sang Mok , Kwon Semin , Leem Jung Woo , Nair Vidhya Vijayakrishnan , Tong Yunjie , Kim Young L 
Published: March 2023

Abstract
Hyperspectral imaging acquires data in both the spatial and frequency domains to offer abundant physical or biological information. However, conventional hyperspectral imaging has intrinsic limitations of bulky instruments, slow data acquisition rate, and spatiospectral trade-off. Here we introduce hyperspectral learning for snapshot hyperspectral imaging in which sampled hyperspectral data in a small subarea are incorporated into a learning algorithm to recover the hypercube. Hyperspectral learning exploits the idea that a photograph is more than merely a picture and contains detailed spectral information. A small sampling of hyperspectral data enables spectrally informed learning to recover a hypercube from a red–green–blue (RGB) image without complete hyperspectral measurements. Hyperspectral learning is capable of recovering full spectroscopic resolution in the hypercube, comparable to high spectral resolutions of scientific spectrometers. Hyperspectral learning also enables ultrafast dynamic imaging, leveraging ultraslow video recording in an off-the-shelf smartphone, given that a video comprises a time series of multiple RGB images. To demonstrate its versatility, an experimental model of vascular development is used to extract hemodynamic parameters via statistical and deep learning approaches. Subsequently, the hemodynamics of peripheral microcirculation is assessed at an ultrafast temporal resolution up to a millisecond, using a conventional smartphone camera. This spectrally informed learning method is analogous to compressed sensing; however, it further allows for reliable hypercube recovery and key feature extractions with a transparent learning algorithm. This learning-powered snapshot hyperspectral imaging method yields high spectral and temporal resolutions and eliminates the spatiospectral trade-off, offering simple hardware requirements and potential applications of various machine learning techniques.
Non-alcoholic fatty liver and fibrosis is associated with cardiovascular structure and function in young adults
Authors: Tang Rosalind , Abeysekera Kushala W. M. , Howe Laura D. , Hughes Alun D. , Fraser Abigail 
Published: March 2023

Background:
Non-alcoholic fatty liver disease shares many risk factors with other metabolic disorders. We sought to establish whether non-alcoholic fatty liver disease may be associated with cardiovascular health independently of other known risk factors.

Methods:
In this prospective, population-based cohort of young adults, controlled attenuation parameter-defined liver steatosis, transient elastography-defined liver fibrosis, echocardiography, carotid ultrasonography, and pulse wave analysis were assessed at age 24 years. We examined associations between liver and cardiovascular measures, with and without accounting for demographics, body mass index, alcohol, smoking, blood pressure, lipidemia, glycemia, and inflammation.

Results:
We included 2047 participants (mean age 24.4 y; 36.2% female): 212 (10.4%) had steatosis, whereas 38 (1.9%) had fibrosis. Steatosis was associated with cardiovascular measures after adjusting for demographics, but with more comprehensive adjustment, steatosis only remained associated with stroke index [β (95% CI) of −1.85 (−3.29, −0.41) mL/m2] and heart rate [2.17 (0.58, 3.75) beats/min]. Fibrosis was associated with several measures of cardiovascular structure and function after full adjustment for risk factors, including left ventricular mass index [2.46 (0.56, 4.37) g/m2.7], E/A ratio [0.32 (0.13, 0.50)], tricuspid annular plane systolic excursion [0.14 (0.01, 0.26) cm], carotid intima-media thickness [0.024 (0.008, 0.040) mm], pulse wave velocity [0.40 (0.06, 0.75) m/s], cardiac index [−0.23 (−0.41, −0.06) L/min⋅m2], and heart rate [−7.23 (−10.16, −4.29) beats/min].

Conclusions:
Steatosis was not associated with measures of cardiovascular structure and function nor with subclinical atherosclerosis after adjusting for known cardiovascular risk factors. Fibrosis, however, was associated with several cardiovascular measures, including indicators of subclinical atherosclerosis, even after full adjustment. Further follow-up will help determine whether cardiovascular health worsens later with steatosis alone.
Acute severe hepatitis as a presenting symptom in clinically stable patients admitted with SARS-CoV-2 Omicron infection
Authors: Swain Liam A. , Ambasta Anshula , Munhoz Erika Prando , Omodon Onyebuchi , Urbanski Stefan J. , Nguyen Henry H. 
Published: March 2023

Background:
Suggested mechanisms for SARS-CoV-2 direct liver infection have been proposed by others to involve both cholangiocytes and hepatocytes. Early clinical studies have highlighted abnormal liver biochemistry with COVID-19 infection as often not being severe, with elevated liver enzymes <5X the upper limit of normal.

Methods:
Liver enzymes were evaluated and compared in patients admitted with a diagnosis of COVID-19 in a deidentified Internal Medicine-Medical Teaching Unit/hospitalist admission laboratory database. Comparisons in the incidence of severe liver injury (alanine aminotransferase >10 times upper limit of normal) were made for patients with pre-Omicron SARS-CoV-2 (November 30, 2019, to December 15, 2021) and Omicron SARS-CoV-2 (December 15, 2021, to April 15, 2022). Comprehensive hospital health records were also reviewed for the 2 patient cases discussed. One patient had a liver biopsy that was evaluated with H&E and immunohistochemistry staining using an antibody against COVID-19 spike protein.

Results:
The evaluation of a deidentified admissions laboratory database found the incidence of severe liver injury was 0.42% with Omicron versus 0.30% with pre-Omicron variants of COVID-19. In both patient cases discussed, abnormal liver biochemistry and a negative comprehensive workup strongly suggest COVID-19 as the cause of severe liver injury. In the one patient with liver biopsy, immunohistochemistry staining suggests SARS-CoV-2 presence in the portal and lobular spaces in association with immune cell infiltration.

Conclusions:
The Omicron variant of SARS-CoV-2 should be considered in the differential diagnosis of severe acute liver injury. Our observation suggests that this new variant, either through direct liver infection and/or mediating immune dysfunction, can result in severe liver injury.
RETINAL ISCHEMIA AFTER FOCAL CEREBRAL ARTERIOPATHY IN A YOUNG GIRL
Authors: Benvenuto Franco , Colorado-Zavala Maria F. , Ruiz-Lozano Raul E. , Gonzalez-Dutra Maria L. , Kadzielski Carina , Ancona-Lezama David 
Published: March 2023

Purpose:
We present a case of an ischemic retinopathy with severe vision loss secondary to a childhood stroke.

Methods:
Case report.

Results:
An otherwise healthy 9-year-old girl presented with a 1-day history of impaired gait and speech. After performing computed tomography and magnetic resonance imaging, thrombosis of the left internal carotid artery was observed and a diagnosis of ischemic stroke was established. Serological autoimmune, coagulation, and viral panels were unrewarding. Cardiac, inflammatory, and coagulation disorders were ruled out. The cause was attributed to a focal cerebral arteriopathy, a common cause of childhood stroke. The patient was treated with mechanical thrombectomy followed by anticoagulation. The day after, the patient referred vision loss of 20/100 in the left eye. Fundus evaluation of the left eye depicted diffuse intraretinal hemorrhages and cotton-wool spots and there was retinal whitening at the posterior pole. Six weeks after, VA dropped to counting fingers.

Conclusion:
A macular optical coherence tomography revealed diffuse atrophic changes in the inner retinal layers at the macula, and the angio-optical coherence tomography showed an enlarged foveal avascular zone. We propose ischemia-reperfusion as the primary explanation of this unusual event.
“Factors Associated with Court Outcomes of Medical Malpractice Litigations involving Breast Reductions: 1990-2020”
Authors: Gong Jung Ho , Kim Daniel D , King Victor A , Mehrzad Raman 
Published: March 2023

Background:
7.4% of physicians in the United States face risk of undergoing medical malpractice litigations each year. Breast reduction surgeries are performed often, but specific factors of breast reduction malpractice litigations associated with the outcome and indemnity payments to plaintiffs are unknown.

Methods:
Using the Westlaw legal database, we analyzed plaintiff and defendant characteristics, alleged reasons for malpractice, case outcomes, and payments to plaintiffs among medical malpractice lawsuits involving breast reductions with final jury verdicts or settlements using logistic regressions.

Results:
96 malpractice litigations with jury verdicts or settlements involving breast reduction surgeries between 1990 and 2020 met out inclusion/exclusion criteria. The average reported plaintiff age was 39 years (SD, 15). A total of 28 (29.2%), 48 (50.0%), and 20 (20.8%) cases occurred in the 1990-1999, 2000-2009, and 2010-2020 periods, respectively. 15 (15.6%) cases were held in New York. Most cases were in favor of defendants (N=65, 67.7%). Among 14 (14.6%) cases with nipple malpositioning as a sustained injury, 8 (57.1%) of them were ruled in favor of plaintiffs. Nipple malpositioning had increased odds of plaintiff verdict or settlement vs defendant verdict (OR, 1.33 [95% CI, 1.03 to 1.74]; P=0.03). Median payment to plaintiffs were $221,348 (range, $4,375 to $3,500,000) for plaintiff verdicts and $650,000 (range, $250,000 to $750,000) for settlements.

Conclusions:
Most breast reduction malpractice litigations were ruled in favor of defendants. Nipple positioning should be taken into high consideration by plastic surgeons performing breast reductions to avoid malpractice litigations and indemnity payments.
Patient Registry and Outcomes for Breast Implants and Anaplastic Large Cell Lymphoma Etiology and Epidemiology (PROFILE): Updated Report 2012 – 2020
Authors: McCarthy Colleen M. , Roberts John , Mullen Erin , Loyo-Berrios Nilsa , Clemens Mark W. , Yoon Sung W. , Levinson Howard , Sommers Katie , Hume Keith , Carr Logan 
Published: March 2023

Introduction:
In January 2011, the FDA released a safety communication regarding the potential association between breast implants and anaplastic large cell lymphoma (BIA-ALCL). In 2012, the American Society of Plastic Surgeons, The Plastic Surgery Foundation, and the FDA signed a cooperative research and development agreement to develop a patient registry entitled the " Patient Registry and Outcomes F or breast Implants and anaplastic large cell Lymphoma etiology and Epidemiology" or “PROFILE" Registry.

Methods:
This is an updated report of registry findings.

Results:
From August 2012 to August 2020, 330 unique, suspected or confirmed cases of BIA-ALCL in the US were reported to PROFILE. This includes 144 cases newly reported since the 2018 publication. Median time from implantation of any device to BIA-ALCL diagnosis was 11 years (range 2 - 44 years). At the time of presentation, 91% of cases had local symptoms and 9% had concurrent systemic symptoms. The most common local symptom was seroma seen in 79% of patients. All patients had a history of a textured device; there were no patients who had a confirmed smooth-only device history. Approximately, 11% of the reported cases were diagnosed with Stage 1A disease (TNM Staging Classification).

Conclusions:
The PROFILE Registry continues to be an essential tool in unifying the collection of granular level data pertaining to BIA-ALCL. This data emphasizes the critical importance of detailed tracking of BIA-ALCL cases and will contribute significantly to our understanding of the relationship between breast implants and ALCL.
“The Resting Angle Suture”
Authors: Finocchi Valerio , Todaro Mattia , Çakir Bariş , Cervelli Daniele 
Published: March 2023

Summary:
The goal of every rhinoplasty surgeon is the creation of both a functionally and aesthetically pleasing nose. The lateral crura resting angle is a key concept that has recently emerged, we believe that it should always be taken into consideration to achieve a satisfactory result.
In this paper, we describe a novel technique: the resting angle suture, the idea for this suture comes from the inversion suture used to correct ectropion deformity in lower eyelid surgery.
What We Talk About When We Talk About Coping
Authors: Bamdad Michaela C. , Vitous Crystal Ann , Rivard Samantha J. , Anderson Maia , Lussiez Alisha , De Roo Ana , Englesbe Michael J. , Suwanabol Pasithorn A. 
Published: March 2023

Objective:
To explore how surgery residents cope with unwanted patient outcomes including postoperative complications and death.

Background:
Surgery residents face a variety of work-related stressors that require them to engage in coping strategies. Postoperative complications and deaths are common sources of such stressors. Although few studies examine the response to these events and their impacts on subsequent decision-making, there has been little scholarly work exploring coping strategies among surgery residents specifically.

Methods:
This study investigated the ways, in which general surgery residents cope with unwanted patient outcomes, including complications and deaths. Mid-level and senior residents (n = 28) from 14 academic, community, and hybrid training programs across the United States participated in exploratory semistructured interviews conducted by an experienced anthropologist. Interview transcripts were analyzed iteratively, informed by thematic analysis.

Results:
When discussing how they cope with complications and deaths, residents described both internal and external strategies. Internal strategies included a sense of inevitability, compartmentalization of emotions or experiences, thoughts of forgiveness, and beliefs surrounding resilience. External strategies included support from colleagues and mentors, commitment to change, and personal practices or rituals, such as exercise or psychotherapy.

Conclusions:
In this novel qualitative study, general surgery residents described the coping strategies that they organically used after postoperative complications and deaths. To improve resident well-being, it is critical to first understand the natural coping processes. Such efforts will facilitate structuring future support systems to aid residents during these difficult periods.
Association of Intellectual Disability with Delayed Presentation and Worse Outcomes in Emergency General Surgery
Authors: Zondlak Allyse N. , Oh Esther J. , Neiman Pooja U. , Fan Zhaohui , Taylor Kathryn K. , Sangji Naveen F. , Hemmila Mark R. , Scott John W. 
Published: March 2023

Objective:
To examine the association between intellectual disability and both severity of disease and clinical outcomes among patients presenting with common emergency general surgery (EGS) conditions.

Background:
Accurate and timely diagnosis of EGS conditions is crucial for optimal management and patient outcomes. Individuals with intellectual disabilities may be at increased risk of delayed presentation and worse outcomes for EGS; however, little is known about surgical outcomes in this population.

Methods:
Using the 2012-2017 Nationwide Inpatient Sample, we conducted a retrospective cohort analysis of adult patients admitted for 9 common EGS conditions. We performed multivariable logistic and linear regression to examine the association between intellectual disability and the following outcomes: EGS disease severity at presentation, any surgery, complications, mortality, length of stay, discharge disposition, and inpatient costs. Analyses were adjusted for patient demographics and facility traits.

Results:
Of 1,317,572 adult EGS admissions, 5,062 (0.38%) patients had a concurrent ICD-9/-10 code consistent with intellectual disability. EGS patients with intellectual disabilities had 31% higher odds of more severe disease at presentation compared with neurotypical patients (aOR 1.31; 95% CI 1.17–1.48). Intellectual disability was also associated with a higher rate of complications and mortality, longer lengths of stay, lower rate of discharge to home, and higher inpatient costs.

Conclusion:
EGS patients with intellectual disabilities are at increased risk of more severe presentation and worse outcomes. The underlying causes of delayed presentation and worse outcomes must be better characterized to address the disparities in surgical care for this often under-recognized but highly vulnerable population.
Selecting DCD Recipients Using Predictive Indices
Authors: Ganni Saif , Handing Greta , Anand Adrish , Barrett Spencer , Galvan Nhu Thao Nguyen , O’Mahony Christine , Goss John A. , Cotton Ronald T. , Rana Abbas 
Published: March 2023

Background.
Donation after circulatory death (DCD) allografts might represent one of the largest untapped sources of liver allografts. Our aim was to identify independent recipient risk factors that predict mortality in DCD allograft recipients to preselect optimal candidates for successful transplantation. Furthermore, we compared the application of our newly constructed DCD Recipient Selector Index (RSI) score to previously developed models to determine superiority in predicting recipient survival.

Methods.
Using the Organ Procurement and Transplantation Network database, we performed univariate and multivariate retrospective analyses on 4228 DCD liver allograft recipients.

Results.
We identified 8 significant factors and incorporated them into the weighted RSI to predict 3-mo survival following DCD liver transplantation with a C-statistic of 0.6971. The most significant recipient risk factors were recipient serum sodium levels >150 mEq/L at transplant, recipient albumin <2.0 g/dL at transplant, and a history of portal vein thrombosis. Because Model for End-Stage Liver Disease (MELD) score components were included as individual predictors, the DCD RSI predicts survival independently of MELD. Upon comparison with 3 previous recipient risk scores—Balance of Risk, Renal Risk Index, Patient-Survival Outcomes Following Liver Transplantation—the DCD RSI was determined to be superior at selecting optimal candidates pre-DCD transplantation, yielding a C-statistic of 0.6971.

Conclusions.
After verifying the performance of predictive indices for selection of DCD recipients, the DCD RSI is best used to preselect patients for optimized outcomes after DCD transplantation. This can increase utilization of DCD donors by improving outcomes.
Insights From Chronic ECoG by RNS
Authors: Traner Christopher B. , King-Stephens David 
Published: March 2023

Summary:
The NeuroPace responsive neurostimulation system (RNS) has revolutionized the care of patients suffering from focal epilepsy since its approval in 2014. One major advantage of this device is its innate ability to gather long-term electrocorticographic (ECoG) data that the device uses in its novel closed-loop treatment paradigm. Beyond the standard stimulation treatments, which have been demonstrated to be safe and well-tolerated, the data collected by the RNS provide valuable information, such as the long-term circadian and ultradian variations that affect seizure risk, obtained under naturalistic conditions. Additionally, these data inform future surgical procedures, supplementing clinically reported seizures by patients, assessing the response to newly added anti-seizure medications, helping to forecast the risk of future seizures, and understanding the mechanisms of certain long-term outcomes in patients with postsurgical epilepsy. By leveraging these data, the delivery of high-quality clinical care for patients with epilepsy can only be enhanced. Finally, these data open significant avenues of research, including machine learning and artificial intelligence algorithms, which may also translate to improved outcomes in patients who struggle with recurrent seizures.
Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage
Authors: Azad Kimi , Guilligay Delphine , Boscheron Cecile , Maity Sourav , De Franceschi Nicola , Sulbaran Guidenn , Effantin Gregory , Wang Haiyan , Kleman Jean-Philippe , Bassereau Patricia , Schoehn Guy , Desfosses Ambroise , Weissenhorn Winfried 
Published: March 2023

AbstractThe endosomal sorting complex required for transport (ESCRT) is a highly conserved protein machinery that drives a divers set of physiological and pathological membrane remodeling processes. However, the structural basis of ESCRT-III polymers stabilizing, constricting and cleaving negatively curved membranes is yet unknown. Here we present cryo electron microscopy structures of membrane-coated CHMP2A-CHMP3 filaments of two different diameters at 3.3 and 3.6 Å resolution. The structures reveal helical filaments assembled by CHMP2A-CHMP3 heterodimers in the open ESCRT-III conformation, which generates a partially positive charged membrane interaction surface, positions short N-terminal motifs for membrane interaction and the C-terminal VPS4 target sequence towards the tube interior. Inter-filament interactions are electrostatic, which facilitate filament sliding upon VPS4-mediated polymer remodeling. Fluorescence microscopy as well as high speed atomic force microscopy imaging corroborate that CHMP2A-CHMP3 polymers and VPS4 can constrict and cleave narrow membrane tubes, thus acting as a minimal membrane fission machinery.