bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENERAPAN PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR OPERASI TEKNIK KIMIA
Authors: Handayani Wuri , Alimin Alimin , Hastini Hastini 
Published: May 2023

Penerapan model pembelajaran Problem Based Learning (PBL) untuk meningkatkan aktivitas dan hasil belajar peserta didik Kelas XII Kimia Industri 1 mata pelajaran Operasi Teknik Kimia II. Penelitian ini adalah penelitian tindakan kelas yang bertujuan untuk meningkatkan aktivitas dan hasil belajar pada mapel Operasi Teknik Kimia melalui Model Pembelajaran Problem Based Learning (PBL). Subjek penelitian ini adalah Siswa Kelas XII Kimia Industri 1 SMK Negeri 1 Tuban sebanyak 16 siswa. Metode yang digunakan diskusi dengan penerapan TPACK. Pengumpulan data dilakukan dengan menggunakan teknik observasi dan evaluasi di akhir pembelajaran di setiap akhir siklus. Hasil penelitian ini menunjukkan bahwa: (1). Siklus I keaktifan siswa mencapai 43,75% dan hasil belajar yang tuntas mencapai 69% , (2) Siklus II terjadi peningkatan keaktifan siswa menjadi 62,5% dan hasil belajar yang tuntas mencapai 75%, (3) Siklus III terjadi peningkatan keaktifan siswa menjadi 75% dan hasil belajar yang tuntas mencapai 88%. Model Pembelajaran Problem Based Learning (PBL) dapat meningkatkan aktivitas dan hasil belajar pada mata pelajaran Operasi Teknik Kimia II.
A comparison of the mineral element content of 70 different varieties of pear fruit (Pyrus ussuriensis) in China
Authors: Liu Chang , Li Honglian , Ren Aihua , Chen Guoyou , Ye Wanjun , Wu Yuxia , Ma Ping , Yu Wenquan , He Tianming 
Published: May 2023

Background
Pyrus ussuriensis (Maxim.) is a unique pear tree that grows in northern China. The tree has strong cold resistance and can withstand low temperatures from −30 °C to −35 °C. Due to its unique growth environment, its fruit is rich in minerals and has much higher levels of minerals such as K, Ca and Mg than the fruit of Pyrus pyrifolia (Nakai.) and Pyrus bretschneideri (Rehd.) on the market, and many say the ripe fruit tastes better than other varieties. A comprehensive analysis of the characteristics of mineral elements in the fruits of different varieties of P. ussuriensis will provide a valuable scientific basis for the selection, breeding and production of consumer varieties of P. ussuriensis, and provide a more complete understanding of nutritional differences between fruit varieties.

Methods
In this study, 70 varieties of wild, domesticated and cultivated species of P. ussuriensis from different geographical locations were compared. Targeting four main mineral elements and eight trace mineral elements contained in the fruit, the differences in mineral content in the peel and pulp of different varieties of P. ussuriensis were analyzed, compared and classified using modern microwave digestion ICP-MS.

Results
The mineral elements in the fruit of P. ussuriensis generally followed the following content pattern: K > P > Ca > Mg > Na > Al > Fe > Zn > Cu > Cr > Pb > Cd. The mineral element compositions in the peel and pulp of different fruits were also significantly different. The four main mineral elements in the peel were K > Ca > P > Mg, and K > P > Mg > Ca in the pulp. The mineral element content of wild fruit varieties was higher than that of cultivated and domesticated varieties. Correlation analysis results showed that there was a significant positive correlation between K, P and Cu in both the peel and pulp of P. ussuriensis fruit (P < 0. 01). Cluster analysis results showed that the 70 varieties of P. ussuriensis could be divided into three slightly different categories according to the content of the peel or pulp. According to the contents of the fruit peel, these varieties were divided into: (1) varieties with high Na, Mg, P, K, Fe and Zn content, (2) varieties with high Ca content and (3) varieties with medium levels of mineral elements. According to the fruit pulp content, these varieties were divided into: (1) varieties with high Mg, P and K content, (2) varieties with low mineral element content, and (3) varieties with high Na and Ca content. The comprehensive analysis of relevant mineral element content factors showed that ‘SSHMSL,’ ‘QYL,’ ‘SWSL’ and ‘ZLTSL-3’ were the best varieties, and could be used as the focus varieties of future breeding programs for large-scale pear production.
Viability of Spermatozoa in Goat's Liquid Semen after Adding Sweet Orange Essential Oil to The Andromed Extender
Authors: Sitepu Sukma Aditya , Marisa Julia , Rianto Aditiya Amanda 
Published: May 2023

Aims: To find out the percentage of live spermatozoa after diluting the goat's liquid semen using an andromed extender plus sweet orange essential oil.
Study Design: Randomized Block Design.
Place and Duration of Study: Sample: Galang, Deli Serdang Regency, Indonesia, between December 2022 and January 2023.
Methodology: The research procedure starts with the preparation of semen extender, collection of fresh semen, dilution of semen and equilibration. This research obtained conducted using a Randomized Block Design consisting of 5 treatment levels and five replications. Semen storage using 3 Bucks, which has done for three days. As a treatment is the addition of sweet orange essential oil as much as (P0) 0%, (P1) 0.25%, (P2) 0.5%, (P3) 0.75% and (P4) 1% on the andromed extender. The observed variable was percentage viability spermatozoa evaluated before equilibration and after equilibration.
Results: The results showed that the addition of sweet orange essential oil had a not significant effect (P <0.01) to viability of spermatozoa. The results of adding sweet orange essential oil to the extender (after equilibration) were 80% (P0), 80% (P1), 80% (P2), 80% (P3) and 81% (P4).
Conclusion: Adding sweet orange essential oil to andromed had no effect on the viability of goat spermatozoa in liquid semen.
Identification and Prioritization of Challenges in Accessing ICT Tools by Agricultural Extension Professionals in Northern Districts of West Bengal
Authors: Prasad C. Vara , Pradhan K. 
Published: May 2023

The potential of Information and Communications Technologies (ICTs) for agriculture in the form of various knowledge management portals has been harnessed by various agricultural developmental organizations and so on. But still, there is a gap in the rural community's adoption and access to such technology. There are many reasons for this adoption lag, in the case of identifying such focused issues in accessing the ICTs, will be the key to addressing those challenges. In such a resilient backdrop, this article investigates by identifying and prioritising the challenges in accessing ICT tools for sustainable agriculture by agricultural system actors in the northern districts of West Bengal. The present study was conducted in two northern districts of West Bengal viz. Cooch Behar and Alipurduar districts. Two hundred respondents included from these two districts were selected randomly for the present study. The sample includes 60 percent of the farmers and 40 percent of extension personnel including scientists from State Agriculture University, Krishi Vigyan Kendra, Assistant directors of State Department of Agriculture, input dealers and grassroots-level extension professionals working in various farmers, clubs and NGOs. These respondents were interviewed through a structured, pre-tested interview schedule developed to measure the extent of ICTs usage designed with the help of the online Google forms and offline interview schedule. The obtained data were processed with the help of statistical tools like frequency, percentage, mean, standard deviation and Rank Based Quotient (RBQ). The constraints identified were, ‘lack of training and practical exposure towards ICTs’ (64.8%), followed by ‘high cost of ICT tools (64.55%), ‘insufficient local language information’ (62%), ‘low network connectivity’ (60.90%), ‘unavailability of different ICT tools’ (60.60%), ‘lack of skill in handling ICTs’ (58.65%), ‘lack of confidence in operating ICTs’ (55.40%), ‘high cost of repairing for ICT devices’ (49.40%), ‘irregular power supply’ (37.95%), and ‘lack of awareness of benefits of ICTs’ (36.40%).
Impact of Financial Support on Transforming China's Energy Economy
Authors: Xiaoyan Zhang, 
Published: May 2023

This paper aims to study the financial tools and policies the People's Republic of China (PRC) can adopt to support its energy transformation initiatives. Improving the energy sector and expanding renewable energy sources are crucial to China's efforts to reduce its carbon emission by transitioning into a green energy economy. In this regard, finance-related problems are inextricably linked to China's financial growth and are one of the significant obstacles to its energy transitioning initiative. This study establishes a mixed-method approach to investigate its financial capability for the transformation phase and the ramifications to be incurred. A descriptive research design outlines data from the past three decades on its different renewable energy consumption. This research presents convincing proof demonstrating that financial progress is crucially significant and generates a total of 42.42% to the variety of green energy growth via an assessment utilizing macro-level data. Time series-based analysis with the vector autoregressive model (VAR) is used to compare the variables' past and current observations. The study's findings comprehensively demonstrate policy analysis, forecasting, and data describing China's fiscal ability to transform its energy economy through a practical approach such as green finance. The feasibility of equity financing, introducing financial instruments such as Green Bonds, and funding small-scale renewable energy projects is crucial in giving the nation the financial support necessary for the transformation. In particular, the capital sector is the most critical element, followed by foreign investment. Simple comparisons between the EU and US situations show that the EU approach is more pertinent; therefore, Chinese authorities should pay closer attention.
Outbreak of Cholera in Ghana: A Systematic Review from 2010 to 2020
Authors: Apenteng John Antwi , Korsah Samuel , Tagoe Miriam , Nortey Nathaniel Nene , Korsah Jessica , Wobetsey Benedicta Delase , Owusu Frederick Akuffo 
Published: May 2023

Background: Cholera affects several hundred thousand individuals worldwide each year. According to estimates, more than 20 million individuals in Ghana are at danger of contracting the illness. However, research from Asia and other continents continues to be a major source of information for understanding cholera epidemiology in Africa, particularly in its coastal nations. The purpose of the study was to evaluate Ghana's cholera epidemics each year.
Methods: A thorough analysis of articles that have been published on cholera outbreaks worldwide and in Ghana. A thorough search was done in the databases of Science Direct, PubMed, and Google Scholar to retrieve and to review research works published on cholera.
Results: Findings suggest cholera has been a significant public health issue for Ghana every year since the first case was reported in 1970. Greater Accra is the area with the most cholera cases each year, with Accra being the district with the most cases. Greater Accra alone reported 58.5% of all cholera cases in Ghana from 1998 to 2017. However, the least affected regions in Ghana are the Upper West, Northern, Upper East, and Volta region. The cause of these cholera outbreaks is subpar sanitation and contaminated water. Annual cholera outbreaks occur in Ghana, where more attention is needed. Multiple deaths have been caused by these epidemics.
Conclusion: Improved sanitation and provision of adequate clean drinking water can help curb the incidence of cholera and its devastating effects on individuals and the country as a whole.
Preventive Effects of Traditional Plant Concoction “Combo” on the Cyclophosphamide-Induced Ovarian Toxicity in Wistar Rats
Authors: Okoroafor Dorcas Okayo , Isirima Joshua Charles 
Published: May 2023

Exposure to chemotherapeutic agents like cyclophosphamide (a drug for cancer treatment), leads to infertility due to its toxic effect on the ovaries. Combo, “a commonly used plant concoction in traditional medicine for the treatment of infertility” is composed of Clove (dried flower), garlic (bulb), ginger (rhizome), and turmeric (rhizome). The aim of this study was to evaluate the possible prophylactic effects of Combo therapy in cyclophosphamide-induced ovarian toxicity in female Wistar rats. Female Wistar rats were divided into 6 groups (A-F) of 6 animals each. Group A (normal control) received distilled water only. Group B (negative control) received 200mg/kg of cyclophosphamide only, while group C (positive control) received only 29mg/kg of Combo. On the other hand, groups D, E and F were pretreated with Combo doses of (15, 29, and 290 mg/kg) and were later treated with 200mg/kg of cyclophosphamide after 7 days. All administrations were done orally. The reproductive hormones assayed were oestrogen and progesterone, while the oxidative stress biomarkers evaluated include glutathione, malondialdehyde, and nitric oxide. Their levels were used as diagnostic markers for assessing the reproductive functions of the ovaries. Combo pre-treatment significantly (p<0.05) decreased the levels of malondialdehyde and nitric oxide, and significantly (p<0.05) increased glutathione, oestrogen and progesterone levels when compared with cyclophosphamide group. Histopathological investigation showed that Combo mitigated degenerative cells in follicles, stromal oedema, and atresia of the follicles when compared with cyclophosphamide group. In conclusion, Combo has fertility potentials and can protect against ovarian degeneration in cyclophosphamide-induced toxicity.
Common Causes of Neonatal Death in Calabar, South-South Nigeria: An Autopsy Study
Authors: Ipeh Ugbem Theophilus , Kingsley Akaba , Edem Ushie David , Venn Juliet , Martin Nnoli , Abeng Ebughe Godwin , Olukayode Oshatuyi 
Published: May 2023

Background: Neonatal deaths are deaths of live born babies occurring before 28 completed days. The vast majority occur in low-income countries like Nigeria with a high neonatal mortality rate. There is paucity of autopsy studies due to refusal of family to give consent for such procedures.
Aim: To identify the commonest causes of neonatal death in 53 neonatal autopsies in Calabar, Nigeria.
Materials and Methods: Detailed postmortem was carried out using lettules techniques and bits taken for histological analysis to ascertain the cause of death. Other relevant contributory factors such as the gestational age, mode of delivery, place of birth, antemortem cause of deaths and maternal obstetric history were obtained from the medical records and autopsy request forms.
Results: In the one-year retrospective study of 53 neonatal autopsies, male: female ratio was 1: 0.83 and mean age at death was 6.5 + 7.3 days, ranging from 1 to 28 days. The commonest cause of neonatal death was severe birth asphyxia seen in 10 cases (18.9%), followed by kernicterus in 6 cases (11.3%), birth trauma seen in 6 cases (11.3%), congenital heart disease seen in 5 cases (9.4%), and prematurity seen in 5 cases (9.4%).
Conclusion: The study confirms the usefulness of neonatal autopsy in ascertaining the definitive cause of death. Severe birth Asphyxia was identified as the commonest cause of death in the neonatal period followed by birth trauma, kernicterus and congenital heart diseases.
Impact of Recreational and Leisure Activities on the Quality of Life of Parents of Children with Autism Spectrum Disorders
Authors: Sharma Ojaswita , Jain Neha , Meena S. K. 
Published: May 2023

This study examines the effect of participation in leisure and recreational activities on quality of life among parents of children with Autism Spectrum Disorders (ASD) in Jaipur, India. The study focuses on the challenges faced by parents of children with ASD and their impact on the parents' QOL. Additionally, this paper highlights the need to consider the mental health of parents in the interventions proposed for children with neurodevelopmental disorders.
The article explores the effect of leisure and recreational activities on the quality of life among parents of children with ASD, a relevant topic in the rehabilitation field. Parents of children with ASD often experience high levels of stress and anxiety, which can negatively impact their quality of life. Participating in leisure and recreational activities has been suggested as a potential way to reduce stress and improve well-being. The present study aimed to investigate the efficacy of such interventions.
The results of the study indicate that participation in leisure and recreational activities can significantly improve the quality of life of parents of children with ASD. The study provides support for the use of leisure and recreational activities as a rehabilitation intervention for parents of children with ASD. The findings suggest that healthcare professionals working with families affected by ASD should consider incorporating leisure and recreational activities into their interventions to improve the well-being of parents. Overall, the study highlights the importance of addressing the needs of parents of children with ASD and provides evidence-based support for the use of leisure and recreational activities in rehabilitation programs.
The article is relevant to the rehabilitation field as it highlights the importance of considering the mental health of parents in interventions proposed for children with neurodevelopmental disorders. It also emphasizes the need to incorporate leisure and recreational activities as part of the treatment plan to enhance the QOL of parents of children with ASD. The valence points to take note of in the discussion include the impact of leisure and recreational activities on the QOL of parents and the need to provide support for parents of children with neurodevelopmental disorders.
Exosomal circ‐AHCY promotes glioblastoma cell growth via Wnt/β‐catenin signaling pathway
Authors: Li Yuhui , Zheng Xuan , Wang Jiangong , Sun Mingyang , Li Dan , Wang Zhuo , Li Jingwu , Li Yufeng , Liu Yongliang 
Published: May 2023

AbstractBackgroundGlioblastoma (GBM) is the most aggressive brain tumor. Reportedly, circular RNAs (circRNAs) participate in regulation of the development and progression of diverse cancers, including GBM.MethodsDysregulated circRNAs in GBM tissues were screened out from GEO database. The expression of candidate circRNAs in GBM cells was measured by qRT‐PCR. Loss‐of function assays, including colony formation assay, EdU assay, TUNEL assay, and flow cytometry analysis were conducted to determine the effects of circ‐AHCY knockdown on GBM cell proliferation and apoptosis. Animal study was further used to prove the inhibitory effect of circ‐AHCY silencing on GMB cell growth. Mechanistic experiments like luciferase reporter, RNA pull‐down and RNA‐binding protein immunoprecipitation (RIP) assays were performed to unveil the downstream molecular mechanism of circ‐AHCY. Nanosight Nanoparticle Tracking Analysis (NTA) and PKH67 staining were applied to identify the existence of exosomes.ResultsCirc‐AHCY was confirmed to be highly expressed in GBM cells. Circ‐AHCY silencing suppressed GBM cell proliferation both in vitro and in vivo. Mechanistically, circ‐AHCY activates Wnt/β‐catenin signaling pathway by sequestering miR‐1294 to up‐regulate MYC which activated CTNNB1 transcription. It was also found that circ‐AHCY recruited EIF4A3 to stabilize TCF4 mRNA. Enhanced levels of TCF4 and β‐catenin contributed to the stability of TCF4/β‐catenin complex. In turn, TCF4/β‐catenin complex strengthened the transcriptional activity of circ‐AHCY. Exosomal circ‐AHCY derived from GBM cells induced abnormal proliferation of normal human astrocytes (NHAs).ConclusionExosomal circ‐AHCY forms a positive feedback loop with Wnt/β‐catenin signaling pathway to promote GBM cell growth.
Noble Metal Ion‐Directed Assembly of 2D Materials for Heterostructured Catalysts and Metallic Micro‐Texturing
Authors: Little Joshua M. , Sun Jiayue , Kamali Ali , Chen Amy , Leff Asher C. , Li Yang , Borden Leah K. , Dissanayake Thilini U. , Essumang Deborah , Oseleononmen Benita O. , Liu Dongxia , Woehl Taylor J. , Chen Po‐Yen 
Published: May 2023

AbstractAssembling 2D‐material (2DM) nanosheets into micro‐ and macro‐architectures with augmented functionalities requires effective strategies to overcome nanosheet restacking. Conventional assembly approaches involve external binders and/or functionalization, which inevitably sacrifice 2DM's nanoscale properties. Noble metal ions (NMI) are promising ionic crosslinkers, which can simultaneously assemble 2DM nanosheets and induce synergistic properties. Herein, a collection of NMI–2DM complexes are screened and categorized into two sub‐groups. Based on the zeta potentials, two assembly approaches are developed to obtain 1) NMI‐crosslinked 2DM hydrogels/aerogels for heterostructured catalysts and 2) NMI–2DM inks for templated synthesis. First, tetraammineplatinum(II) nitrate (TPtN) serves as an efficient ionic crosslinker to agglomerate various 2DM dispersions. By utilizing micro‐textured assembly platforms, various TPtN–2DM hydrogels are fabricated in a scalable fashion. Afterward, these hydrogels are lyophilized and thermally reduced to synthesize Pt‐decorated 2DM aerogels (Pt@2DM). The Pt@2DM heterostructures demonstrate high, substrate‐dependent catalytic activities and promote different reaction pathways in the hydrogenation of 3‐nitrostyrene. Second, PtCl4 can be incorporated into 2DM dispersions at high NMI molarities to prepare a series of PtCl4–2DM inks with high colloidal stability. By adopting the PtCl4–graphene oxide ink, various Pt micro‐structures with replicated topographies are synthesized with accurate control of grain sizes and porosities.
Protonated Charge Reversal Nanodrugs for Active Targeting Clearance of Helicobacter Pylori Accompanied by Gut Microbiota Protection
Authors: Liu Cong , Chen Simiao , Sun Caixia , Zuo Wanchao , Wu Pengcheng , Wang Shuren , Dai Jianjun , Xing Yingying , Hou Yanglong , Ju Yanmin 
Published: May 2023

AbstractHelicobacter pylori (H. pylori) is listed as a definite carcinogen and clinical triple therapy is less satisfactory because H. pylori colonizes beneath the gastric mucous layer and easily forms biofilm. More importantly, the frequent and excessive use of antibiotics causes a disorder of gut microbiota due to the lack of targeting to H. pylori. Here, a kind of protonated charge reversal metal based nanodrugs (MNDs)—ZnO‐Ag‐mercaptoacetamide@chitosan for H. pylori eradication treatment without affecting beneficial gut microbiota is prepared. In H. pylori infected mouse model, the MNDs actively target submucosa colonized H. pylori owing to mucous penetrability and protonation effect, and further eradicate H. pylori and its biofilm by producing metal ions and reactive oxygen species. Transcriptomic analysis shows that there are no obvious side effects to intestinal microorganisms during the treatment. Besides, it is found that the MNDs are great potential to remove gastric inflammation along with the blocking of inflammatory pathways and the reduction of virulence factors, which is related to the infiltration of CD4+ T cells to clear H. pylori.