bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteínas del filtrado del cultivo de Mycobacterium bovis promueven apoptosis independientemente de la activación de las caspasas en macrófagos bovinos
Authors: Jimenez Vazquez Itzel Nalleli , Espitia Pinzon Clara , Negrete Abascal Erasmo , Benítez Guzmán Alejandro , Morán Julio , Gutierrez Pabello José Ángel 
Published: September 2023

La apoptosis es un proceso que ocurre de manera normal en los tejidos. Se caracteriza por cambios morfológicos en la célula. Las especies del complejo Mycobacterium tuberculosis inducen este fenómeno; en el modelo bovino, se demostró que tanto Mycobacterium bovis como sus extractos proteicos, inducen apoptosis independientemente de la activación de las caspasas, sin embargo, la identidad de las proteínas en los extractos proteicos se desconoce. En este estudio reportamos que, a través de cromatografía de exclusión por peso molecular, se obtuvieron fracciones proteicas con la capacidad de inducir fragmentación del DNA en macrófagos de bovinos independientemente de la activación de la caspasa 3. Asimismo, mediante cromatografía líquida-espectrometría de masas (LC-MS) se identificó la presencia de tres candidatos responsables de la actividad biológica: MPB70, MPB83 y chaperonina de 60 kDa.
Content of Polyphenolic Compounds and Biological Activity of Berries, Leaves and Flowers of Crataegus L.
Authors: Żurek Natalia , Kapsuta Ireneusz , Cebulak Tomasz 
Published: September 2023

Abstract
In this study, the berries, leaves and flowers of six species of hawthorn (Crataegus L.) were evaluated for bioactive compounds (polyphenols, flavonoids, procyanides, UPLC profile) and their antioxidant activity (ABTS•+, CUPRAC, iron ion chelation, scavenging O2
·- and OH− radicals). Most of the analyzes were performed for the first time for this material. The content of bioactive compounds differed significantly both between the species and morphological parts studied. In particular, the highest content of polyphenols was determined for hawthorn berries (301.65 to 387.16 mg/100 g d.w.), including the highest concentration for C. x subsphaericea. The polyphenolic profile of this species was dominated by flavan-3-ols, with procyanidin trimer, (-)-epicatechin and procyanidin dimer being the most numerous. Hawthorn berries were also characterized by the highest antioxidant activity, among which the species C. laevigata x rhipidophylla x monogyna showed the strongest antiradical activity (0.91 mmol TE/g and 294.96 µg/ml for tests with the ABTS•+ and OH− radical, respectively) and chelating iron ions (700.28 µg/ml). In conclusion, the results explain the traditional use of hawthorn in folk medicine and indicate a potentially new wider application as a source of natural antioxidants in the design of functional foods.
Risk Profiling of Exposures to Potentially Toxic Metals PTM(S) Through Noodles Consumption. A Case Study of Human Health Risk Assessment
Authors: Jakkielska Dorota , Frankowski Marcin , Kurzyca Iwona , Ziołafrankowska Anetta 
Published: September 2023

Abstract
This study aimed to quantify levels of the toxic heavy metals metalloid arsenic (As), cadmium (Cd), lead (Pb) and mercury (Hg) in commercially available noodles. Analysis was performed via the acid microwave digestion method followed by inductively coupled plasma mass spectrometry (ICP-MS). Furthermore, the potential health risks resulting from the consumption of noodles by polish consumers were evaluated using the estimated average daily intake of heavy metals (ADIHMs; µg·kg−1 bw·day−1). Additionally, to assess the potential health consequences due to noodle consumption, the total hazard quotient (THQ) and cancer risk (CR) were calculated. The average contents of Pb, As, Cd, and Hg in instant noodle samples were determined as 9.241, 8.483, 29.39, and 1.661 µg·kg−1, respectively. THQ values for heavy metal toxicity were found to be below 1, indicating that the consumer is not exposed to carcinogenic health risks associated with the analyzed metals. Additionally, the rank order of max THQ was Pb < Cd < As < Hg, and the mean THQ was Pb < Hg < As < Cd, while both the max and mean CR rank orders were Pb < Cd < As.
Lyophilized Kale (Brassica oleracea L.) Leaves as an Enhancing Component in Gluten-Free Bread
Authors: Korus Anna , Witczak Mariusz , Juszczak Lesław , Korus Jarosław 
Published: September 2023

Abstract
The objective of the research was to assess the impact of powdered kale (Brassica oleracea L. var. acephala) on the properties of starchy gluten-free dough and bread. Kale lyophilisate was added to the recipe as 3%, 6%, or 9%, replacing the starch. The addition of the kale resulted in a decrease in the dough's strength despite the optimisation of the water content. The presence of kale lyophilisate reduced the volume of the loaves, in comparison with control, resulting in a decrease in crumb porosity and pore density, and an increase in the quantity of large pores. The addition of lyophilised kale at all levels resulted in an increase in taste acceptability, while the 6 and 9% kale decreased the acceptability of the other sensory parameters. The presence of the kale lyophilisate led to a reduction in crumb hardness on individual days of storage compared to the control sample, and the decrease was greater the more kale powder was added to the recipe. Bread with the highest concentration of the kale lyophilisate showed lower enthalpy of retrograded amylopectin decomposition in subsequent days of storage.
The Schooner Enterprise: a Forgotten Key West Murder Case
Authors: Jarvis Robert M. 
Published: September 2023

Abstract
In 1859, Key West found itself transfixed by a sensational criminal trial. Styled United States v. Carcer, Eloy, and Davis, and presided over by William Marvin, the island's legendary federal judge, the case involved a mutiny-murder aboard the slave ship Enterprise. Although famous in its day, the tale has been all but forgotten due to the Great Key West Fire of 1886, which destroyed nearly every record of the affair.
Property Damage Assessment Methods and Models due to Armed Aggression
Authors: Drapikovskyi Oleksandr , Ivanova Iryna 
Published: September 2023

Abstract
The paper deals with the conceptualization of the gross development value to assess direct damages and the restoration needs of lost, destroyed and damaged real estate as a result of armed aggression. A critical review of the existing practice of assessing property damage has been carried out. The measurement units of direct damages and the restoration needs, the evidence base used, the valuation methods for the determination of property damage are analyzed. The methodological potential of compounded cash flow models and the criteria for assessing their reliability is substantiated. A system of valuation models for calculating direct damages and restoration needs is proposed, depending on the category of real estate and market conditions at the valuation date. These valuation models are relatively simple to implement and understandable to the intended users of property damage valuation reports.
MAFIA HUKUM DALAM PERSPEKTIF KEBERLANGSUNGAN DAN PENEGAKAN HUKUM
Authors: Surohmat Surohmat 
Published: September 2023

Abstrak Secara empiris praktik mafia hukum berhubungan dengan adanya campur tangan pihak lain terhadap proses perkara yang sedang ditangani atau diproses oleh lembaga-lembaga penegak hukum. Sementara itu secara teoritis, praktik mafia hukum sangat merugikan dan menggangu keberlangsungan hukum dan proses penegakan hukum, yang menimbulkan masalah yang berkaitan dengan akibat yang ditimbulkan dari adanya praktik mafia hukum, dan penanggulangan dan pencegahan praktik mafia hukum. Tulisan ini bermaksud meneliti tentang dampak yang ditimbulkan oleh praktik mafia hukum serta bagaimana kebijakan penanggulangannya. Penelitian menggunakan metode penelitian hukum normatif dengan pendekatan konseptual dan analitis. Dari hasil penelitian, ditemukan bahwa dampak dari praktik mafia hukum adalah melemahnya tingkat kesadaran masyarakat dan penegak hukum terhadap hakikat, substansi, dan proses penegakan hukum. Adapun kebijakan yang ditempuh untuk memberantas mafia hukum adalah menumbuhkan kesadaran masyarakat akan hukum, termasuk aparat penegak hukum yang terikat pada kode etik penegakan hukum. Kata Kunci: Mafia Hukum, Penegakkan Hukum, dan Kebijakan Hukum. AbstractEmpirically, the practice of the legal mafia is related to the interference of other parties in the process of cases being handled or processed by law enforcement agencies. Meanwhile, theoretically, the practice of mafia law is very detrimental and disrupts the continuity of the law and the process of law enforcement, which creates problems related to the consequences of the practice of mafia law and the prevention of mafia law practice. This paper intends to examine the impact caused by legal mafia practices and how to overcome them. The research uses normative legal research methods with a conceptual and analytical approach. From the results of the research, it was found that the impact of legal mafia practices is the weakening of the level of awareness of the public and law enforcers regarding the nature, substance, and process of law enforcement. The policy pursued to eradicate the legal mafia is to raise public awareness of the law, including among law enforcement officers who are bound by the law enforcement code of ethics.Keywords: Legal Mafia, Law Enforcement, and Legal Policy.
KEBIJAKAN SERTA PERLINDUNGAN HUKUM DALAM URGENSI LEGALITAS BAGI INDUSTRI MIKRO DI KOTA BOGOR
Authors: Ardiansyah Dicky , Muharram Nidhar Irham , Utama Raja Satria , Fadilah Zahra Rahmah 
Published: September 2023

AbstrakPertumbuhan sektor industri dan perdagangan memiliki peran penting dalam perkembangan di bidang ekonomi. Usaha mikro kecil dan menengah (UMKM) yang tumbuh di tengah masyarakat menunjukkan daya tahan yang lebih tinggi dan menjadi penyangga perekonomian suatu negara maupun daerah. Legalitas usaha adalah lisensi yang harus dimiliki oleh semua pengusaha. Legalitas usaha ini berperan asistensi peraturan bagi para pedagang, oleh karena itu pengusaha harus memimpin legalitas usahanya. Surat izin ini bertujuan untuk menghamparkan peraturan legalitas dan urgensi legalitas usaha. Penelitian ini dilakukan secara kualitatif dengan menggunakan tata cara penentuan hukum normatif. Sumber bukti pada saat penulisan ini yaitu data sekunder dan penelitian perpustakaan, khususnya mengenai peraturan perundang-undangan di bidang perindustrian. Hasil pemeriksaan menunjukkan bahwa legitimasi bisnis sangat penting bagi pengusaha. Menurut Pasal 10 Undang-Undang Bisnis Nomor 3 Tahun 2014, setiap bidang kegiatan harus menyimpan izin kegiatan. Oleh karena itu legalitas usaha sangat penting bagi pengusaha, karena izin usaha ini bisa berperan sebagai penyokong hukum bagi pengusaha.Kata Kunci: Industri, UMKM, legalitas, izin, legitmasi, pengusaha. AbstractThe growth of the industrial and trade sectors has an important role in developments in the economic field. Micro, small and medium enterprises (MSMEs) that grow in the midst of society show higher resilience and become a pillar of the economy of a country or region. Business legality is a license that must be owned by all entrepreneurs. The legality of this business plays a regulatory role for traders, therefore entrepreneurs must lead the legality of their business. This permit aims to spread legality regulations and the urgency of business legality. This research was conducted qualitatively using normative legal determination procedures. Sources of evidence at the time of writing were secondary data and library research, particularly regarding laws and regulations in the industrial sector. The results of the examination show that business legitimacy is very important for entrepreneurs. According to Article 10 of the Business Law Number 3 of 2014, every field of activity must keep an activity permit. Therefore business legality is very important for entrepreneurs, because this business license can act as a legal support for entrepreneurs.Keywords : Industrial, MSMEs, legality, license, legitimacy, entrepreneur.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KELELAHAN KERJA DI DEPARTMENT AREA PRODUKSI MCD, PLANT M, PT “X” TAHUN 2017
Authors: Rahayu Ririn Puji , Effendi Luqman 
Published: September 2023

Data dari ILO tahun 1998 menyebutkan hampir setiap tahun sebanyak 2 juta pekerja meninggal dunia karena kecelakaan kerja yang disebabkan oleh faktor kelelahan kerja. Penelitian tersebut menyatakan dari 58.115 sampel, 32,8% diantaranya atau sekitar 18.828 sampel menderita kelelahan. Penelitian ini bertujuan untuk meneliti faktor-faktor yang berhubungan dengan kelelahan kerja di Department Area Produksi MCD, Plant M, PT. “X”, Tahun 2017. penelitian ini menggunakan metode penelitian kuantitatif dengan desain studi cross sectional. Populasi dalam penelitian ini adalah seluruh pekerja di Department Area Produksi MCD, Plant M, PT ”X”. Jumlah responden sebanyak 109 orang diambil dengan teknik accidental sampling dan dianalisis dengan analisis univariat dan analisis bivariat. Berdasarkan hasil analisis univariat, responden yang paling banyak mengalami kelelahan sedang (51,4%), berusia 23 tahun (10,1%), status normal(47,7%), tidak memiliki riwayat penyakit (72,5%), riwayat penyakit dengan gangguan pencernaan (14,7%), kebiasaan merokok (52,3%), <10 batang/hari (33,9%), bekerja secara shif (87,2%), terpapar ≥85 Dba (60,6%). Berdasarkan hasil analisis bivariat, terdapat variabel yang menunjukan adanya hubungan yang signifikan dengan kelelahan yaitu variabel kebiasaan merokok ( p=0,045, OR=2,4; CI95%=1,0-5,3 ), shift kerja ( p=0,005, OR=5,6; CI95%=1,6-19,6 ) dan kebisingan ( p=0,000, OR=5,1; CI95%=2,2-12,0 ). Sedangkan variabel yang tidak ada hubungan dengan kelelahan adalah usia, status gizi, dan riwayat penyakit.---Data from the ILO in 1998 states that almost 2 million workers die every year due to work accidents caused by work fatigue. The study stated that of 58,115 samples, 32.8% of them or around 18,828 samples suffered from fatigue. This study aims to examine the factors associated with work fatigue in the MCD Production Area Department, Plant M, PT. "X", 2017. This study uses quantitative research methods with cross sectional study design. The population in this study were all workers in the MCD Production Area Department, Plant M, PT "X". The number of respondents was 109 people taken by accidental sampling technique and analyzed by univariate analysis and bivariate analysis. Based on the results of univariate analysis, the respondents who experienced the most moderate fatigue (51.4%), aged 23 years (10.1%), normal status (47.7%), had no history of disease (72.5%), history diseases with digestive disorders (14.7%), smoking habits (52.3%), <10 cigarettes / day (33.9%), working as a shif (87.2%), exposed to ≥85 Dba (60.6%) %). Based on the results of bivariate analysis, there are variables that show a significant relationship with fatigue, namely the smoking habit variable (p = 0.045, OR = 2.4; CI95% = 1.0-5.3), work shift (p = 0.005, OR = 5.6; CI95% = 1.6-19.6) and noise (p = 0.000, OR = 5.1; CI95% = 2.2-12.0). While the variables that are not related to fatigue are age, nutritional status, and disease history.
Profil dan Beberapa Faktor yang Berhubungan dengan Hemostasis Pasien Diabetes Melitus Tipe 2 Tak Terkontrol
Authors: Ajin Mukhyarjon Muslim , Wahid Irza , Manaf Asman 
Published: September 2023

Hiperkoagulasi merupakan salah satu faktor risiko terjadinya penyakit kardiovaskuler. Resistensi insulin dan hiperglikemia yang meningkat pada diabetes melitus tipe 2 (DMT2) tidak terkontrol, memainkan peran penting dalam patogenesis terjadinya hiperkoagulasi. Meskipun banyak studi telah dilakukan, namun penelitian pada subjek di Indonesia masih terbatas. Penelitian ini bertujuan mengetahui profil dan faktor-faktor yang berhubungan dengan hemostasis pada pasien DMT2 tak terkontrol. Ini merupakan studi analitik observasional dengan rancangan potong lintang. Lima puluh pasien diabetes melitus (DM) tak terkontrol berpartisipasi pada penelitian ini. Variabel bebas meliputi umur, onset dan jenis kelamin, sedangkan variabel terikat adalah prothrombine time (PT), activated partial thromboplastin time (APTT), fibrinogen dan D-dimer. Data dianalisis menggunakan uji Chi-Square dan nilai p<0,05 dianggap bermakna. PT yang rendah tidak ditemukan pada penelitian ini sementara APTT yang rendah ditemukan pada 2% pasien. Hiperfibrinogenemia ditemukan pada 34% pasien dan D-dimer tinggi ditemukan pada 28% pasien. Terdapat hubungan hiperfibrinogenemia dengan onset DM namun tidak dengan umur dan jenis kelamin. D-dimer tinggi berhubungan dengan usia namun tidak dengan gender dan onset penyakit. Studi ini dapat disimpulkan bahwa hiperfibrinogenemia dan D-dimer tinggi sering ditemukan pada pasien DMT2 tidak terkontrol sehingga evaluasinya perlu dipertimbangkan terutama pada DMT2 yang disertai faktor-faktor risiko penyakit kardiovaskuler yang lain.
Faktor-Faktor yang Memengaruhi Kepatuhan Peserta Mandiri Membayar Iuran BPJS di Kelurahan Benda Baru
Authors: Latifah Noor , Nabila Wafa , Fajrini Fini 
Published: September 2023

Badan Penyelenggara Jaminan Sosial (BPJS) merupakan badan penyelenggara yang kepesertaannya bersifat wajib sebagaimana tertuang dalam UU No.40 Tahun 2004. Di wilayah Banten, Kota Tangerang Selatan menduduki peringkat ke-2 sebagai wilayah dengan peserta BPJS terbanyak memiliki tunggakan dalam pembayaran BPJS di mana Kecamatan Pamulang memiliki jumlah tunggakan tertinggi yaitu 32.484 jiwa dan Kelurahan Benda Baru memiliki jumlah tunggakan tertinggi sebesar 4.586 jiwa. Iuran sangat berpengaruh terhadap kelancaran berjalannya BPJS Kesehatan agar tidak terjadi defisit. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang Memengaruhi kepatuhan peserta mandiri dalam membayar iuran BPJS di Kelurahan Benda Baru. Penelitian dilakukan di Kelurahan Benda Baru, Kecamatan Pamulang Kota Tangerang Selatan pada bulan Juli-Agustus Tahun 2019. Sampel yang diambil adalah peserta BPJS mandiri sebanyak 102 orang. Desain penelitian menggunakan cross sectional dengan teknik pengambilan data purposive sampling. Analisis dilakukan dengan uji univariat dan bivariat dengan uji chi-square. Ada hubungan antara pengetahuan dengan kepatuhan peserta mandiri dalam membayar iuran BPJS (p-value = 0,000). Perlu adanya sosialisasi secara rutin dari petugas BPJS Kesehatan mengenai informasi pembayaran iuran tepat waktu.
Quantifying the Influences of Land Use and Rainfall Dynamics on Probable Flood Hazard Zoning
Authors: Nabi Rehman  , Zada Umar , Kashif Haleem  
Published: September 2023

Flooding is Pakistan's most common natural hazard, and it is exacerbated by increased rainfall and urbanization. Khyber Pakhtunkhwa (KPK), Pakistan flood-prone zones were determined by superimposing six flood parameters in an ArcGIS environment: elevation, slope, rainfall accumulation, land cover, soil geometry, and gap/buffer from water channel. Cellular automata based on artificial neural network (CA-ANN) along QGIS plugin module of Land Use Change Simulations (MOLUSCE) was used for predicting year 2050 land use, with a kappa value of 0.83. The results indicated that of the 75775 km2 land area covered by this research region, 3.37% (2553.62 km2) falls in extremely high risk, 18.44% (13972.91 km2) falls in high risk, 11.26% (8532.27 km2) falls in moderate risk, 0.51% (386.45 km2) falls in low risk, and just 66.42% (50329.76 km2) falls in very low risk areas. In KPK, like in any other place, a multi-criteria flood risk-vulnerability assessment is consequently necessary for preparation and post-hazard planning. Without a doubt, the outcomes reported here are crucial for flood risk assessments and hazard management decision-making.
Key words: natural disasters; floods; remote sensing; geographic information system, multi-criteria evaluation; weighted overlay.
Cytomorphological findings in drug defaulters of tuberculous lymphadenitis
Authors: Kumari Aarti , Ahuja Sana , Bajaj Sachin , Zaheer Sufian , Chaitanya Vinod , Agarwal Yatish , Gupta Ratan , Ranga Sunil 
Published: September 2023

Objectives:
Tuberculosis (TB) is an important health problem specially in the developing countries. Although effective chemotherapy is available, compliance of patient is a major challenge. The aim of this study was to describe cytomorphological features of drug defaulters on lymph node on fine-needle aspiration cytology (FNAC) and compare it with newly diagnosed cases.

Material and Methods:
A cross-sectional study was done for a period of 18 months, in which all patients having tuberculous lymphadenitis were included after taking detailed history regarding previous anti-TB drug intake. Cytomorphological findings in drug defaulters were evaluated and compared with newly diagnosed cases.

Results:
There were a total of 150 cases with 120 newly diagnosed and 30 drug defaulters. Splintered epithelioid cell granuloma was seen in 40% of drug defaulters, while it was absent in case of newly diagnosed cases (P < 0.0001). Well-formed epithelioid cell granuloma was most commonly seen in newly diagnosed cases (65.83%) followed by poorly formed granuloma (26.67%). Another significant finding was distribution of eosinophils which were significantly high in case of drug defaulters (56.67%) (P < 0.0001).

Conclusion:
Cytomorphological findings can help in identification of the drug defaulters on FNAC and thus plan further line of treatment.
Surgical Audit of Operated Patients in a Tertiary Care Hospital in Karachi, Pakistan
Authors: Akhtar Huma , Ahmed Hajrah Hilal , Irshad Kanwal , Jamaluddin Muhammad 
Published: September 2023

Objectives
To audit operated patients in emergency and electively from 1st January 2018 to 31st December 2019 in all three surgical departments to know the outcome of the patients at a tertiary care hospital in Karachi, Pakistan.

Material and Methods
A retrospective study conducted in all three Abbasi Shaheed Hospital surgical units from 1st January 2018 to 31st December 2019. In this study total of 5079 patients were included who were admitted through the emergency and surgical outpatient department. They were operated in emergency and elective theaters in all three surgical departments of Abbasi Shaheed Hospital. Data was collected on pre-designed performa from emergency and elective theater, wards, High-dependency unit and Intensive care unit maintained registers by staff.

Results
A total of 5079 cases were operated during January 2018 to December 2019. Among all the age ranges 1282 belongs to the age range of 21-30 years. Amongst which 59.6% were males. The most common diagnosis made in elective patients was chronic calculous cholecystitis (25.8%) and an abscess in emergency (39.4%). The most common procedure performed in elective surgeries was combined laparoscopic and open cholecystectomy (26.8%) and incision and drainage in the emergency (39.4%). Elective surgeries were mainly performed by Associate Professors (28.7). While, emergency surgeries were mainly performed by post-graduate trainees (70.2%). Surgical unit II has performed most surgeries (39.5%). Elective procedure constitutes about (51.60%). Total 19 patients expired out of 350 patients who were shifted or admitted in surgical ICU and 12 patients expired in all three wards.

Conclusion
We have a higher number of elective surgeries as compared to the emergency surgeries. Consultants have performed most of the elective surgeries. Emergency surgeries mostly by residents and senior registrars. We have zero mortalities in our elective surgeries in comparison with emergency surgeries. We call attention to conduct continuous audits at our hospitals and all levels of health care and demand from higher authorized personnels to incorporate audit awareness in our teaching. Along with it, a proper database should be installed with updated records maintenance to improve the lack of health care.