bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aortic arch surgery for type B aortic dissection: How far should we go? The value of a hybrid approach
Authors: Capoccia Massimo , Sherif Mohamed Ashur , Nassef Ahmed , Shaw David , Walker Paul , Evans Betsy , Kaul Pankaj , Elmahdy Walid 
Published: January 2023

AbstractTraditionally, the management of type B aortic dissection has been the domain of the vascular surgeons. Timing and type of intervention still generate debate. We sought to review our early experience with the treatment of this condition based on a hybrid approach following an aortic multi‐disciplinary team meeting involving close cooperation between cardiac surgeons, vascular surgeons, interventional radiologists, vascular anesthetists, and cardiac anesthetists. Four patients (age 41–56 years; 3 males; 1 female) with type B aortic dissection underwent aortic arch surgery through a hybrid approach: one elective procedure consisting of ascending aorta and hemi‐arch replacement with debranching followed by thoracic endovascular aortic repair (TEVAR); one redo procedure requiring aortic arch replacement with hybrid frozen elephant trunk; two acute presentations (aortic arch replacement and debranching followed by TEVAR; AVR with ascending aorta, arch, and proximal descending thoracic aorta replacement with conventional elephant trunk and debranching). Deep hypothermic circulatory arrest was required in three patients. Despite respiratory complications and slightly prolonged postoperative course, all patients survived without onset of stroke, paraplegia, malperfusion, endoleak, or need for re‐exploration. Follow‐up remains satisfactory. Different factors may affect outcome following complex aortic procedures. Nevertheless, close cooperation between cardiac surgeons, vascular surgeons, and interventional radiologists may reduce potential for complications and address aspects that may not be completely within the domain of individual specialists.
Highly Active and Stable Single Atom Rh1/CeO2 Catalyst for CO Oxidation during Redox Cycling
Authors: García‐Vargas Carlos E. , Pereira‐Hernández Xavier Isidro , Jiang Dong , Alcala Ryan , DeLaRiva Andrew T. , Datye Abhaya , Wang Yong 
Published: January 2023

AbstractWe report a single atom Rh1/CeO2 catalyst prepared by the high temperature (800 °C) atom trapping (AT) method which is stable under both oxidative and reductive conditions. Infrared spectroscopic and electron microscopy characterization revealed the presence of exclusively ionic Rh species. These ionic Rh species are stable even under reducing conditions (CO at 300 °C) due to the strong interaction between Rh and CeO2 achieved by the AT method, leading to high and reproducible CO oxidation activity regardless of whether the catalyst is reduced or oxidized. In contrast, ionic Rh species in catalysts synthesized by a conventional impregnation approach (e. g., calcined at 350 °C) can be readily reduced to form Rh nanoclusters/nanoparticles, which are easily oxidized under oxidative conditions, leading to loss of catalytic performance. The single atom Rh1/CeO2 catalysts synthesized by the AT method do not exhibit changes during redox cycling hence are promising catalysts for emission control where redox cycling is encountered, and severe oxidation (fuel cut) leads to loss of performance.
The Buoy Effect: Surface Enrichment of a Pt Complex in IL Solution by Ligand Design
Authors: Hemmeter Daniel , Kremitzl Daniel , Schulz Peter S. , Wasserscheid Peter , Maier Florian , Steinrück Hans‐Peter 
Published: January 2023

AbstractInvited for the cover of this issue are the groups of Hans‐Peter Steinrück and Peter Wasserscheid at the Friedrich‐Alexander‐Universität Erlangen‐Nürnberg. The image depicts two Pt catalysts dissolved in an ionic liquid. For one of them, fluorinated side chains in the ligand system act as buoys leading to pronounced enrichment of the complex at the gas/IL interface, as is evidenced by strongly enhanced Pt signals in angle‐resolved photoelectron spectroscopy. For the complex without fluorinated side chains, no such effect is observed. Read the full text of the article at 10.1002/chem.202203325.
Social Exchange Relationships with Peer Leaders and Ethical Leadership: A Study among Male Military Team Leaders
Authors: Kim Dongkyu , Vandenberghe Christian 
Published: January 2023

AbstractThe present research explores the role of lateral exchange relationships among peer leaders (i.e., leader–leader exchange relationships; PLLX) as drivers of ethical leadership. Across two studies involving male subordinates and leaders pertaining to 150 teams (Study 1) and 158 leader–follower dyads (Study 2) in the Republic of Korea Army, PLLX was found to mediate a positive relation between peer leaders' ethical leadership and focal team leaders' ethical leadership, while controlling for upper leaders' ethical behaviours. Moreover, this relation was moderated by focal leaders' organizational tenure but in opposite directions in the two studies: the relation between peer leaders' ethical leadership and focal leaders' ethical leadership through PLLX was stronger in Study 1 (vs. weaker in Study 2) when tenure was high.
Theropod dinosaurs had primate‐like numbers of telencephalic neurons
Authors: Herculano‐Houzel Suzana 
Published: January 2023

AbstractUnderstanding the neuronal composition of the brains of dinosaurs and other fossil amniotes would offer fundamental insight into their behavioral and cognitive capabilities, but brain tissue is only rarely fossilized. However, when the bony brain case is preserved, the volume and therefore mass of the brain can be estimated with computer tomography; and if the scaling relationship between brain mass and numbers of neurons for the clade is known, that relationship can be applied to estimate the neuronal composition of the brain. Using a recently published database of numbers of neurons in the telencephalon of extant sauropsids (birds, squamates, and testudines), here I show that the neuronal scaling rules that apply to these animals can be used to infer the numbers of neurons that composed the telencephalon of dinosaur, pterosaur, and other fossil sauropsid species. The key to inferring numbers of telencephalic neurons in these species is first using the relationship between their estimated brain and body mass to determine whether bird‐like (endothermic) or squamate‐like (ectothermic) rules apply to each fossil sauropsid species. This procedure shows that the notion of “mesothermy” in dinosaurs is an artifact due to the mixing of animals with bird‐like and squamate‐like scaling, and indicates that theropods such as Tyrannosaurus and Allosaurus were endotherms with baboon‐ and monkey‐like numbers of telencephalic neurons, respectively, which would make these animals not only giant but also long‐lived and endowed with flexible cognition, and thus even more magnificent predators than previously thought.
Gallium(III) Amide Corroles: DNA Interaction and Photodynamic Activity in Cancer Cells
Authors: Li Meng‐Yuan , Yang Wu , Cen Jing‐He , Liu Ling‐Gui , Yang Gang , Liu Hai‐Yang , Liao Yu‐Hui , Zhong Xi‐Hao 
Published: January 2023

AbstractA series of gallium(III) amide corroles including meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Pyridinamide‐phenyl)corrole gallium (III) (1‐Ga), meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Furamide‐phenyl)corrole gallium(III) (2‐Ga) and meso‐5,15‐bis(pentafluorophenyl)‐10‐(4‐Thiophenamide‐phenyl)corrole gallium(III) (3‐Ga) were synthesized. The interaction of these complexes with DNA and their photodynamic antitumor activities have been studied. UV spectra titration showed that these gallium(III) corroles interact with calf thymus DNA (CT‐DNA) through an external binding mode. All three gallium(III) corroles can effectively generate singlet oxygen under illumination and have good photostability. Among the three gallium(III) corroles, 2‐Ga exhibited excellent photodynamic antitumor activity against the tested tumor cell lines under light irradiation (625±2 nm, 0.3 mW/cm2, 1.08 J/cm2). The best phototoxicity was observed by 2‐Ga against HepG2 cells (IC50=6.3±0.9), which is even better than temoporfin (IC50=8.4±1.8). It could block HepG2 cells in the sub‐G0 phase and effectively induce apoptosis of HepG2 cells under 625 nm light irradiation.
Exosome‐derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase‐3‐dependent cleavage
Authors: Ding Lifeng , Zheng Qiming , Lin Yudong , Wang Ruyue , Wang Huan , Luo Wenqin , Lu Zeyi , Xie Haiyun , Ren Liangliang , Lu Haohua , Yu Chenhao , Zhang Jixuan , Shen Danyang , Cheng Sheng , Xia Liqun , Li Gonghui , Xue Dingwei 
Published: January 2023

AbstractBackgroundCircular RNAs (circRNAs) have been reported to play a significant role in tumorigenesis. However, the detailed function of circRNA in prostate cancer (PCa) is still largely unknown.MethodsWe quantified circTFDP2 expression in PCa tissues and adjacent normal tissues using quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR). Colony formation, Cell Counting Kit‐8 (CCK‐8), flow cytometry, transwell, and in vivo progression and metastasis assays were applied to reveal the proliferation and metastatic abilities of circTFDP2 in PCa cells. Mass spectrometry, RNA pulldown, RNA‐immunoprecipitation (RIP), western blotting and immunofluorescence were used for the mechanistic studies. qRT‐PCR and RIP assays were used to explore the regulatory role of eIF4A3 in the biogenesis of circTFDP2. Finally, functional assays showed the effect of circTFDP2‐containing exosomes on PCa cell progression.ResultscircTFDP2 was upregulated in PCa tissues compared with adjacent normal tissues. Furthermore, high circTFDP2 expression was positively correlated with the Gleason score. Functionally, circTFDP2 promoted PCa cell proliferation and metastasis both in vivo and in vitro. Mechanistically, circTFDP2 interacted with poly(ADP‐ribose) polymerase 1 (PARP1) protein in its DNA‐binding domain to prevent it from active caspase‐3‐dependent cleavage, and finally relieved PCa cells from DNA damage. In addition, RNA‐binding protein eIF4A3 can interact with the flanking region of circTFDP2 and promote the biogenesis of circTFDP2. Moreover, exosome‐derived circTFDP2 promoted PCa cell progression.ConclusionsIn general, our study demonstrated that circTFDP2 promoted PCa cell progression through the PARP1/DNA damage axis, which may be a promising therapeutic target for PCa.
(Not) far from home: No sex bias in dispersal, but limited genetic patch size, in an endangered species, the Spotted Turtle (Clemmys guttata)
Authors: Liebgold Eric B. , Dickey Myra J. , Lamb Stephanie M. , Howell Hunter J. , Ransom Tami S. 
Published: January 2023

AbstractSex‐biased dispersal is common in many animals, with male‐biased dispersal often found in studies of mammals and reptiles, including interpretations of spatial genetic structure, ostensibly as a result of male–male competition and a lack of male parental care. Few studies of sex‐biased dispersal have been conducted in turtles, but a handful of studies, in saltwater turtles and in terrestrial turtles, have detected male‐biased dispersal as expected. We tested for sex‐biased dispersal in the endangered freshwater turtle, the spotted turtle (Clemmys guttata) by investigating fine‐scale genetic spatial structure of males and females. We found significant spatial genetic structure in both sexes, but the patterns mimicked each other. Both males and females typically had higher than expected relatedness at distances <25 km, and in many distance classes greater than 25 km, less than expected relatedness. Similar patterns were apparent whether we used only loci in Hardy–Weinberg equilibrium (n = 7) or also included loci with potential null alleles (n = 5). We conclude that, contrary to expectations, sex‐biased dispersal is not occurring in this species, possibly related to the reverse sexual dimorphism in this species, with females having brighter colors. We did, however, detect significant spatial genetic structure in males and females, separate and combined, showing philopatry within a genetic patch size of <25 km in C. guttata, which is concerning for an endangered species whose populations are often separated by distances greater than the genetic patch size.
Promoting ecodesign implementation: The role and development areas of national public policy
Authors: Horn Susanna , Salo Hanna , Nissinen Ari 
Published: January 2023

AbstractThe European Parliament adopted the Circular Economy Action Plan in 2021, with which it identifies the importance of the design phase to improve products' circularity and environmental impacts. With an environmental design approach – ecodesign – companies can proactively reduce, avoid, or eliminate adverse environmental impacts that occur during the life cycle of a product. However, the practical implementation of ecodesign is not widely studied, hence, there is little evidence indicating a comprehensive or structured use of ecodesign in companies. Moreover, current policies are not considered as sufficient to promote the systematic use of the concept. This research studies company views on drivers and barriers of ecodesign, its practical implementation means, and compiles the most important development areas for the public sector to support ecodesign implementation in companies. Based on our study, the key drivers and barriers relate to company values, customer demand, tools, information, competition, regulations, and standards, reflecting both internal and external factors. With regard to implementation, ecodesign has been a systemic and continuous activity in companies, ranging from products and services to processes and marketing, but often with no dedicated resources. Subsequently, the key development areas for public policy are the establishment of stable and predictable regulations; provision of clear and structured information; provision of ecodesign tools supporting decision‐making and which are easily available for different purposes and sectors. These mutually supportive areas are important for promoting ecodesign more systemically. In future policy actions, it would be important to further introduce interlinkages and synergies between various policy tools.
Safety and efficacy of MitraClip in acutely ill (NYHA Class IV) patients with mitral regurgitation: Results from the global EXPAND study
Authors: Shuvy Mony , von Bardeleben Ralph Stephan , Grasso Carmelo , Raake Philip , Lurz Philipp , Zamorano Jose L. , Asch Federico , Kar Saibal , Maisano Francesco ,   EXPAND Investigators
Published: January 2023

AbstractAimPatients with severe mitral regurgitation (MR) and acute heart failure (HF) have refractory symptoms without adequate response to medical therapy. The objective of this analysis was to assess the impact of the MitraClip device in acutely ill HF patients, characterized by NYHA Class IV at baseline, in a real‐world, contemporary setting.Methods and resultsEXPAND was a prospective, multicenter, international study enrolling patients with MR who consented to receive the MitraClip System at 57 sites globally. The study outcomes included acute procedural success (APS), quality of life, heart failure hospitalizations (HFH), and all‐cause mortality. The study population comprised 1,041 patients, with 118 patients having baseline NYHA Class IV, and 922 having baseline NYHA Class I/II/III. NYHA Class IV patients had a significantly higher rate of baseline co‐morbidities and secondary MR aetiology compared with NYHA Class I/II/III patients. APS was achieved in 92.4% of NYHA Class IV patients and significant improvement in MR grade to ≤Mild (1+) in 90.7% of subjects at 30 days and 92.9% at 1 year was observed. 1‐year‐mortality was higher in the NYHA Class IV subjects compared with the NYHA Class I/II/III subjects (29.2% vs. 17.7%, P < 0.01). Significant improvement in functional capacity assessed by NYHA Functional Class and Quality of Life assessed through KCCQ score was observed. At 1 year, 72.6% of NYHA Class IV subjects improved to NYHA Class I/II and ΔKCCQ was 31.2 (24.1, 38.3) compared with baseline.ConclusionIn the prospective, real‐world EXPAND study, MitraClip in patients with severe MR and NYHA Class IV was found to be safe and effective in treating MR, and significantly improving QoL and long‐term clinical outcomes.
Tissue‐resident memory T (TRM) cells: Front‐line workers of the immune system
Authors: Osman Maleika , Park Simone L. , Mackay Laura K. 
Published: January 2023

AbstractTissue‐resident memory T (TRM) cells play a vital role in local immune protection against infection and cancer. The location of TRM cells within peripheral tissues at sites of pathogen invasion allows for the rapid detection and elimination of microbes, making their generation an attractive goal for the development of next‐generation vaccines. Here, we discuss differential requirements for CD8+ TRM cell development across tissues with implications for establishing local prophylactic immunity, emphasizing the role of tissue‐derived factors, local antigen, and adjuvants on TRM cell generation in the context of vaccination.
CoxP/Hollow Porous C3N4as Highly Efficient Schottky Contact Photocatalyst for H2Evolution from Water Splitting
Authors: Zhang Jiadong , Zhang Lijing , Mao Chen , Gu Ruilong , Wang Wei , Wang Yuxin , Zhou Ziyan , Yan Bin , Bi Lingling , Fu Qiuyan , Zhu Yiyao 
Published: January 2023

AbstractPhotocatalytic water splitting to obtain hydrogen energy can transform low‐density solar to high density, new and clean energy in a clean way, which is one of the ideal ways to solve the energy crisis and environmental pollution. In this paper, The CoxP/hollow porous C3N4composite photocatalytic material was synthesized by simple methods. The photocatalytic hydrogen production rate of CoxP/hollow porous C3N4reaches 1602 μmol g−1 h−1, which is 151 times of that of pure C3N4. The reasons for the high photocatalytic H2evolution activity of CoxP/hollow porous C3N4could be summarized as follows: (1) the hollow and porous structure of C3N4shows higher light capture efficiency, larger specific surface area and more surface active sites. (2) metalloid CoxP loaded forms the Schottky contact with C3N4, which improves the photogenerated charges separation efficiency of C3N4, prolongs the photogenerated charges lifetime and improves the photocatalytic H2evolution activity of C3N4. (3) The higher conductivity of metalloid CoxP and the lower overpotential of hydrogen production are other reasons for the higher activity of photocatalytic hydrogen production of CoxP/hollow porous C3N4. This work provides an important role for the design of efficient, stable, and efficient construction of photocatalysts for solar energy conversion.
Lewis Acid‐Assisted Molybdenum(VI) Complexes with S, N‐bidentate Ligands to Reduce Nitrate
Authors: Lang Jia‐Jia , Mi Pengbing , Wang Xiao‐Juan , Gao Shu‐Qin , Tan Xiangshi , Lin Ying‐Wu 
Published: January 2023

AbstractTwo readily‐accessible molybdenum complexes with low sterically hindered S, N‐bidentate ligands were designed for the reduction of nitrate to nitrite. The Lewis acid Sc(III) acted as a significant co‐catalyst to enhance the catalytic efficiency by activating the N−O bond of nitrate. This study indicates that molybdenum complexes in cooperation with a Lewis acid offer functional Mo‐catalyst systems, which present functional artificial models of the natural molybdenum enzymes.
Carpet Beater Molecules: Synthesis and Characterization of Functional Hexa‐peri‐benzocoronene–Alkyne Coupling Products
Authors: Müller Johannes , Buck Janina , Hirsch Andreas 
Published: January 2023

AbstractWithin the scope of this paper, nine π‐expanded mono‐substituted 5,8,11,14,17‐pentakis‐(tert‐butyl)‐hexa‐peri‐hexabenzocoronenes (HBC) are introduced. 2‐Iodo‐5,8,11,14,17‐pentakis‐(tert‐butyl)‐hexa‐peri‐hexabenzocoronene served as precursor and was reacted with ethynyltrimethylsilane in a Sonogashira coupling reaction. The acetylene unit is used as a linker and can undergo another Sonogashira coupling reaction combining different phenyl coupling partners with the HBC core. The electron‐withdrawing groups such as nitrile, pyridine and carbonyl species (aldehyde, methylester, carboxylic acid) as well as the three quinoxaline based species (diphenylquinoxaline, dibenzo[a,c]phenazine, phenanthro[4’,5’‐a,b,c]phenazine) serve as substitution moieties. Their influence on the optoelectronic properties were investigated by UV/Vis absorption spectroscopy demonstrating a maximum redshift of 7 nm compared to starting compound 2‐Iodo‐5,8,11,14,17‐pentakis‐(tert‐butyl) HBC. As for the phenanthro[4’,5’‐a,b,c]phenazine substituted HBC a dramatic decrease in the intensity of the absorption of the UV/Vis spectrum was observed. The fluorescence spectroscopy pointed out that the dibenzo[a,c]phenazine and phenanthro[4’,5’‐a,b,c]phenazine substitution changed the spectra to one broad peak departing from the characteristic HBC‐like emission pattern.
Rapid evaluation of structural soundness of steel frames using a coupling coefficient (CC)‐based method
Authors: Shen Shao‐Dong , Kurata Masahiro 
Published: January 2023

AbstractA method is proposed for evaluating the post‐earthquake condition of steel frame structures based on the coupling coefficient (CC). The CC is an index that reflects the internal force distribution of each storey and damage mechanism in frames. It is computed using the drift distribution of the maximum structural response estimated from limited monitoring data and the design drawings of the target structure. Preliminary finite element analyses showed that the CC contains some important information that is not obvious in displacement responses, such as the global and local working modes of the structure. Useful information of this type includes whether the damage to each storey is mainly distributed on the beams or columns. An incremental dynamic analysis with an 18‐storey steel frame tested at the E‐Defense shaking table facility confirmed that the structural condition identified by the CC‐based method corresponds to the damage information reported by visual inspection. The analysis results verify the theory of the CC‐based method and provide limit values for the damage grades of steel frames.
Analysis of fractional Navier–Stokes equations
Authors: Jafari Hossein , Zair Muslim Yusif , Jassim Hassan Kamil 
Published: January 2023

AbstractIn this study, we apply the fractional Laplace variational iteration method (FLVIM), a computer methodology for exploring fractional Navier–Stokes equation solutions. In light of the theory of fixed points and Banach spaces, this paper also explores the uniqueness and convergence of the solution of general fractional differential equations obtained by the suggested method. In addition, the fractional Laplace variational iteration method solution's error analysis is covered. The computational technique also clearly demonstrates the validity and dependability of the suggested method for solving fractional Navier‐Stokes equations. Furthermore, the obtained solutions are a perfect fit with previously established solutions.