bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the Virchow pioneering report on brain corpora amylacea: shedding light on recurrent controversies
Authors: Riba Marta , Romera Clara , Alsina Raquel , Alsina-Scheer Gerard , Pelegrí Carme , Vilaplana Jordi , del Valle Jaume 
Published: June 2023

AbstractThe first report of corpora amylacea (CA) is attributed to Morgagni, who described them in the prostate in the eighteenth century. Nearly a hundred years later, and following the lead started by Purkinje, Virchow described them in the brain. He made a detailed description of the most useful techniques to visualize them, but he failed to describe the cause of why CA do appear, why they are mainly linked with the elderly, and which is their clinical significance. Although in the last two centuries CA have received little attention, recent data have been able to describe that CA accumulate waste products and that some of them can be found in the cerebrospinal fluid and lymphatic nodes, after being released from the brain. Indeed, CA have been renamed to wasteosomes to underline the waste products they gather and to avoid confusion with the term amyloid used by Virchow, now widely related to certain protein deposits found in the brain. Here, after providing a commented English translation of Virchow’s findings, we provide a recent update on these structures and their connection with the glymphatic system insufficiency, for which wasteosomes should be considered a hallmark, and how these bodies could serve as diagnostic or prognostic markers of various brain conditions.
Characterization of a putative metal-dependent PTP-like phosphatase from Lactobacillus helveticus 2126
Authors: Priyodip Paul , Balaji Seetharaman 
Published: June 2023

AbstractTo date, there are very limited reports on sequence analysis and structure-based molecular modeling of phosphatases produced by probiotic bacteria. Therefore, a novel protein tyrosine-like phosphatase was characterized from L. helveticus 2126 in this study. The purified bacterial phosphatase was subjected to mass spectrometric analysis, and the identity of constructed sequence was analyzed using peptide mass fingerprint. The 3-D structure of protein was elucidated using homology modeling, while its stability was assessed using Ramachandran plot, VERIFY 3D, and PROCHECK. The bacterium produced an extracellular phosphatase of zone diameter 15 ± 0.8 mm on screening medium within 24 h of incubation. This bacterial phosphatase was highly specific towards sodium phytate as it yielded the lowest Km value of 299.50 ± 4.95 μM compared to other phosphorylated substrates. The activity was effectively stimulated in the presence of zinc, magnesium, and manganese ions thereby showing its PTP-like behavior. The phosphatase showed a molecular mass of 43 kDa, and the corresponding M/Z ratio data yielded 46% query coverage to Bacillus subtilis (3QY7). This showed a 61.1% sequence similarity to Ligilactobacillus ruminis (WP_046923835.1). The final sequence construct based on these bacteria showed a conserved motif “HCHILPGIDD” in their active site. In addition, homology modeling showed a distorted Tim barrel structure with a trinuclear metal center. The final model after energy minimization showed 90.9% of the residues in the favorable region of Ramachandran’s plot. This structural information can be used in genetic engineering for improving the overall stability and catalytic efficiency of probiotic bacterial phosphatases.
Are Bad Leaders Indeed Bad for Employees? A Meta-Analysis of Longitudinal Studies Between Destructive Leadership and Employee Outcomes
Authors: Li Peikai , Yin Kui , Shi Jian , Damen Tom G. E. , Taris Toon W. 
Published: June 2023

AbstractDoes having bad leaders have long-lasting adverse effects on employees? While previous studies have primarily viewed subordinate deviant behavior as a crucial consequence of destructive leadership, aggression theory suggests that subordinate deviant behavior could also be an antecedent of destructive leadership. To address this question, we conducted a meta-analysis by focusing on longitudinal field studies (i.e., time-lagged and panel designs), and investigated the longitudinal associations as well as the reciprocal relationships between destructive leadership and employee outcomes. Results from 82 articles with 104 independent prospective and longitudinal studies (N = 30,314) showed that destructive leadership has a lagged detrimental impact on employee behavioral (e.g., OCB, workplace deviance, CWB, and avoidance) and attitudinal outcomes (e.g., job satisfaction and work commitment). There are no significant differences between destructive leadership and employee outcomes for the long-term and short-term effects. Surprisingly, after accounting for auto-regression effects, the cross-lagged analysis showed that destructive leadership did not significantly relate to employees’ negative behavior over time, whereas negative employee behavior did relate to destructive leadership across time. Theoretical and practical implications are discussed.
Social Entrepreneurship as a Family Resemblance Concept with Distinct Ethical Views
Authors: Lancastre Filipa , Lages Carmen , Santos Filipe 
Published: June 2023

AbstractAlmost 25 years after Dees’ article on the meaning of social entrepreneurship, conceptual controversy persists. Based on a qualitative analysis of 209 definitions of social entrepreneurship and respective academic articles, we argue that the concept follows a family resemblance structure and identify the 12 distinct attributes that comprehensively define it. Membership in social entrepreneurship is not defined by a case possessing a universally accepted set of criterial features but by carrying shared attributes with other cases. The family resemblance structure points to the persistent fallacy of using the same term to label different phenomena and cautions researchers against causal homogeneity assumptions among different conceptual subtypes. Assuming a descriptive stance, we shed light on how distinct ethical positions relate to different definitions of social entrepreneurship. Among the existing conceptual variety, we identify four prominent subtypes and find that ‘market-based’ conceptualizations relate to economism, the ‘social business’ subtype relates to rule utilitarian positions, ‘efficiency-driven’ definitions are associated with hedonistic act utilitarian views, and the ‘transformational impact’ subtype is akin to a eudemonic act utilitarian stance.
A Structural Equation Approach and Modelling of Pre-service Teachers' Perspectives of Cybersecurity Education
Authors: Ayanwale Musa Adekunle , Sanusi Ismaila Temitayo , Molefi Rethabile Rosemary , Otunla Adekunle Olusola 
Published: June 2023

AbstractThe increasing technology reliance in today’s world has amplified the need for cybersecurity education for all. Hence, initiatives regarding the integration of cybersecurity education within the pre-college level have begun to emerge in recent times. However, limited research exists regarding in-service or pre-service teachers’ perspectives on this phenomenon. More importantly, the need to understand pre-service teachers’ perceptions; since their perceptions may significantly influence how the prospective teachers respond to cybersecurity issues and also affect their behavior toward learning and promoting cybersecurity education in the future. Consequently, in order to gain insight into how candidates entering the teaching profession regard cybersecurity, 451 pre-service teachers were sampled in a major public university in Lesotho. The prospective teachers recruited across various departments in the faculty of education responded to an online survey that comprised 33 items gauged from five constructs which include personal cybersecurity awareness, perceived self-efficacy of learning cybersecurity, personal relevance of cybersecurity knowledge, behavioral intention towards learning cybersecurity and actual learning of cybersecurity. We analyzed the response from the survey by utilizing the structural equation modelling approach. Our findings showed that our hypothesized model was mostly accepted. The result suggests that practitioners and researchers in the related field need to raise the pre-service teacher’s behavioral intention to learn cybersecurity by helping them realize the implication for their personal lives and society. We discussed our findings in relation to the proposed research model and highlighted the implication for teacher education programs. Finally, the article concludes with limitations and identifies future research agenda.
Displaying Inner Experience Through Language and Body in Community Theater Rehearsals
Authors: Harjunpää Katariina , Deppermann Arnulf , Sorjonen Marja-Leena 
Published: June 2023

AbstractUsing multimodal conversation analysis, we investigate how novices learning the “inner body” acting technique in the context of a community theater project share their experiences of the bodily exercises through verbal and embodied conduct. We focus on how verbal description and bodily enactment of the experience mutually elaborate each other, and how the experienced sensorimotor and affective qualities are made to be witnessed and recognized by the others. Participants describe their experiences without naming qualities. Instead, a display of the experienced qualities is made accessible to others through coordinating the unfolding talk and bodily conduct. In particular, we show how grammatical and action projection is fulfilled by interconnected verbal and embodied conduct, with body movement and posture giving off ineffable experiential qualities. The moving body appears both as a source of the experience and as a resource for depicting perceived qualities to others; additional resources (non-specific person reference and gaze aversion) contribute to organizing the subjective and intersubjective layers of the reflection of the experiences. The study contributes to and extends recent research on sensoriality in interaction by focusing on phenomena of proprioception and interoception. The data are two cases drawn from 60 h of video-recordings made in the context of a devised community theater project. The data are in Finnish with English translations.
Neutrophils in STAT1 Gain-Of-Function Have a Pro-inflammatory Signature Which Is Not Rescued by JAK Inhibition
Authors: Parackova Zuzana , Vrabcova Petra , Zentsova Irena , Sediva Anna , Bloomfield Marketa 
Published: June 2023

AbstractSTAT1 gain-of-function (GOF) mutations cause an inborn error of immunity with diverse phenotype ranging from chronic mucocutaneous candidiasis (CMC) to various non-infectious manifestations, the most precarious of which are autoimmunity and vascular complications. The pathogenesis centers around Th17 failure but is far from being understood. We hypothesized that neutrophils, whose functions have not been explored in the context of STAT1 GOF CMC yet, might be involved in the associated immunodysregulatory and vascular pathology. In a cohort of ten patients, we demonstrate that STAT1 GOF human ex-vivo peripheral blood neutrophils are immature and highly activated; have strong propensity for degranulation, NETosis, and platelet-neutrophil aggregation; and display marked inflammatory bias. STAT1 GOF neutrophils exhibit increased basal STAT1 phosphorylation and expression of IFN stimulated genes, but contrary to other immune cells, STAT1 GOF neutrophils do not display hyperphosphorylation of STAT1 molecule upon stimulation with IFNs. The patient treatment with JAKinib ruxolitinib does not ameliorate the observed neutrophil aberrations. To our knowledge, this is the first work describing features of peripheral neutrophils in STAT1 GOF CMC. The presented data suggest that neutrophils may contribute to the immune pathophysiology of the STAT1 GOF CMC.
Active Thermography for Non-invasive Inspection of Wall Painting: Novel Approach Based on Thermal Recovery Maps
Authors: Rippa M. , Vigorito M. R. , Russo M. R. , Mormile P. , Trojsi G. 
Published: June 2023

AbstractThe development of novel non-invasive diagnostic methods to support artwork conservation is an important aspect for preserving human culture. For many years the restoration work has been assisted by various technologies with digital imaging systems playing an important role. An important request is the use of non-invasive diagnostic tools that allow the detection of defects and a comparison between their state before and after consolidation treatments. Among these, infrared thermography is a well-known non-invasive and contact-less imaging method that can enable low-cost in situ analysis. This work investigates the feasibility of an innovative active thermography approach based on the calculation of thermal recovery maps to detect detachments in wall painting. Its capabilities are tested on a work of art datable in the XVIII century by making measurements in situ before and after a consolidation work. The results achieved show how this analysis can significantly support the restoration works in the detection of critical/defective areas and for a pre-post restoration comparison of the artwork.
De-noising the image using DBST-LCM-CLAHE: A deep learning approach
Authors: Chakraverti Sugandha , Agarwal Pankaj , Pattanayak Himansu Sekhar , Chauhan Sanjay Pratap Singh , Chakraverti Ashish Kumar , Kumar Manoj 
Published: June 2023

AbstractHistogram Equalization (HE) is one of the most popular techniques for this purpose. Most histogram equalization techniques, including Contrast Limited Adaptive Histogram Equalization (CLAHE) and Local Contrast Modification CLAHE (LCM CLAHE), use a fixed block size technique for feature enhancement. Due to this, all these state of art techniques are used to give poor denoising performance after feature enhancement. In this paper, a deep learning based new approach, namely Dynamic Block Size Technique (DBST), is used to improve image denoising. In this approach, we use the Categorical Subjective Image Quality (CSIQ) image set, an image database generally used for preprocessing of images. The results obtained from experiments show better performance for different important parameters (used by state of art techniques). The work is novel in the preprocessing of images because in this work, we classify the image depending upon the image features for selecting appropriate block sizes dynamically during preprocessing. Proposed work outperforms in terms of PSNR, MSE, NRMSE, SSIM and SYNTROPY. The average respective values are 18.92, 863.86, 0.25, 0.81 and 19.35 and are better in comparison of CLAHE and LCM CLAHE.
Does the rule matter? A comparison of preference elicitation methods and voting rules based on data from an Austrian regional parliamentary election in 2019
Authors: Darmann Andreas , Klamler Christian 
Published: June 2023

AbstractBased on data collected in connection with the 2019 parliamentary election in the Austrian region of Styria, we analyze (the use of) different voting rules. Following previous empirical studies in the literature, we use the results of an empirical survey to show that the choice of a voting rule will impact the outcome of an election (if revealed preferences are sincere), at least in certain parts of the social ranking. In addition, we observe a certain desire for voting rules using more fine-grained preference information. In that context, we investigate the degree of consistency in the voters’ declaration of preferences, something of relevance when different voting rules, that require different levels of information, are used. Finally, we discuss the occurrence of strategic behavior that can be observed in the data.
Bat use of golf courses depends on surrounding landscape context
Authors: Drake Evan , Vonhof Maarten , Maslo Brooke 
Published: June 2023

AbstractUnderstanding how wildlife responds to altered ecosystems is an important conservation objective. Urban green spaces may support wildlife communities, but their internal and external environments vary substantially. Golf course design and management generally follow standardized best practices, and thus frequently contain similar ecological features. However, studies investigating their conservation value have produced discordant conclusions; therefore, we hypothesize that external environmental factors significantly affect their utility for wildlife. We used acoustic detectors to survey bats at eleven golf courses across a gradient of landscapes (urban, agricultural, and forested) over two years. We used generalized linear mixed models to examine how landscape features surrounding golf courses relate to bat activity. For most species, bat activity was greater on golf courses when the surrounding landscape contained fewer open spaces and more developed land. We conclude that golf courses situated in developed landscapes may provide important foraging habitat for bats. Notably, several species of conservation concern were more active on courses with larger patches of nearby forest. Given that management resources are finite, we recommend using the surrounding landscape to assess the conservation potential of golf courses and allocating effort to improve habitat on golf courses that are most likely to benefit bats and other wildlife.
Pattern of care for re-irradiation in locally recurrent rectal cancer: a national survey on behalf of the AIRO gastrointestinal tumors study group
Authors: Mantello Giovanna , Galofaro Elena , Caravatta Luciana , Di Carlo Clelia , Montrone Sabrina , Arpa Donatella , Chiloiro Giuditta , De Paoli Antonino , Donato Vittorio , Gambacorta Maria Antonietta , Genovesi Domenico , Lupattelli Marco , Macchia Gabriella , Montesi Giampaolo , Niespolo Rita Marina , Palazzari Elisa , Pontoriero Antonio , Scricciolo Melissa , Valvo Francesca , Franco Pierfrancesco 
Published: June 2023

Abstract
Purpose
Radical resection (R0) represents the best curative treatment for local recurrence (LR) rectal cancer. Re-irradiation (re-RT) can increase the rate of R0 resection. Currently, there is a lack of guidelines on Re-RT for LR rectal cancer. The Italian Association of Radiation and clinical oncology for gastrointestinal tumors (AIRO-GI) study group released a national survey to investigate the current clinical practice of external beam radiation therapy in these patients.

Material and methods
In February 2021, the survey was designed and distributed to members of the GI working group. The questionnaire consisted of 40 questions regarding center characteristics, clinical indications, doses, and treatment techniques of re-RT for LR rectal cancer.

Results
A total of 37 questionnaires were collected. Re-RT was reported as an option for neoadjuvant treatment in resectable and unresectable disease by 55% and 75% of respondents, respectively. Long-course treatment with 30–40 Gy (1.8–2 Gy/die, 1.2 Gy bid) and hypofractionated regimen of 30–35 Gy in 5 fractions were used in most centers. A total dose of 90–100 Gy as EqD2 dose (α/β = 5 Gy) was delivered by 46% of the respondents considering the previous treatment. Modern conformal techniques and daily image-guided radiation therapy protocols were used in 94% of centers.

Conclusion
Our survey showed that re-RT treatment is performed with advanced technology that allow a good management of LR rectal cancer. Significant variations were observed in terms of dose and fractionation, highlighting the need for a consensus on a common treatment strategy that could be validated in prospective studies.
Partner selection strategies of SMEs for reaching the Sustainable Development Goals
Authors: Castellani Paola , Rossato Chiara , Giaretta Elena , Vargas-Sánchez Alfonso 
Published: June 2023

AbstractThe paper aims to investigate the characteristics of SMEs’ partners that can better contribute to the achievement of the SDGs. Given the explorative nature of this research, a qualitative methodology is adopted, with a longitudinal case study employed as the research method. The Wråd case study confirmed that SMEs can contribute to the achievement of the SDGs by developing partnerships with multiple stakeholders. In addition, this research revealed that the characteristics of the SMEs’ partners can be referred to the four following dimensions: economic, environmental, social and purpose. Furthermore, it proposed that quality utility value, technique level, profitability are the subdimensions of the economic dimension and that resource consumption efficiency, pollution production, energy efficiency, environment management system and environment equipment and facilities are the subdimensions of the environmental dimension. This research expressed also that public health, employee engagement, brand reputation and local communities’ influence are the subdimensions of the social dimension. Finally, it underlined that sustainability-oriented awareness development, sustainable orientation, sustainable collective culture, proactive managerial skills, organisational learning and proactive and innovative leadership are the subdimensions of the purpose dimension. In line with previous studies underlining the importance of increasing the TBL dimensions, this study suggests a further extension of this theory with the ‘purpose’ dimension. This study highlights the importance of developing a vision supported by a social awareness of the problems that need to be addressed and that transcend the fashion sector. Further researches could explore a larger sample of SMEs operating in different businesses and the point of view of the SME’s partners.
Liver fibrosis quantified by image morphometry predicts clinical outcomes in patients with non-alcoholic fatty liver disease
Authors: Wang Zhengyi , Jeffrey Gary P. , Huang Yi , De Boer Bastiaan , Garas George , Wallace Michael , Bertot Luis , Adams Leon A. 
Published: June 2023

Abstract
Background and aims
Liver fibrosis predicts adverse clinical outcomes, such as liver-related death (LRD) and hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the accuracy of semi-automated quantification of collagen proportionate area (CPA) as an objective new method for predicting clinical outcomes.

Method
Liver biopsies from patients with NAFLD underwent computerized image morphometry of Sirius Red staining with CPA quantification performed by ImageScope. Clinical outcomes, including total mortality, LRD, and combined liver outcomes (liver decompensation, HCC, or LRD), were determined by medical records and population-based data-linkage. The accuracy of CPA for predicting outcomes was compared with non-invasive fibrosis tests (Hepascore, FIB-4, APRI).

Results
A total of 295 patients (mean age 50 years) were followed for a median (range) of 9 (0.2–25) years totalling 3253 person-years. Patients with CPA ≥ 10% had significantly higher risks for total death [hazard ratio (HR): 5.0 (1.9–13.2)], LRD [19.0 (2.0–182.0)], and combined liver outcomes [15.6 (3.1–78.6)]. CPA and pathologist fibrosis staging (FS) showed similar accuracy (AUROC) for the prediction of total death (0.68 vs. 0.70), LRD (0.72 vs. 0.77) and combined liver outcomes (0.75 vs. 0.78). Non-invasive serum markers Hepascore, APRI, and FIB-4 reached higher AUROC; however, they were not statistically significant compared to that of CPA except for Hepascore in predicting total mortality (0.86 vs. 0.68, p = 0.009).

Conclusion
Liver fibrosis quantified by CPA analysis was significantly associated with clinical outcomes including total mortality, LRD, and HCC. CPA achieved similar accuracy in predicting outcomes compared to pathologist fibrosis staging and non-invasive serum markers.