bluuebunny/crossref_metadata_2025_split huggingface dataset:
Japanese pharmacists’ information strategy using behavioural economics: provision of numerical information with ‘peak-end rule’ improves willingness to take a hypothetical medication
Authors: Yoshida Akira , Horii Norimitsu , Oshima Shinji , Oshima Shigeru , Kobayashi Daisuke 
Published: January 2023

AbstractObjectivesLow medication adherence is considered a cause of exacerbated diseases and greater economic losses. Hence, information strategies that improve patients’ willingness to take medications have received considerable attention. Newer information strategies that utilise the ‘peak-end rule’ proposed in behavioural economics were investigated in this study to advance strategy development.MethodsAn online scenario survey was conducted among adults aged 20–79 years in Japan. One of four medication counselling videos on a hypothetical hypertension drug narrated by a pharmacist was viewed by the respondents and their willingness to take the medication was evaluated. The four scenarios differed according to the presence or absence of risk probability and the order in which risk and benefit were provided.Key findingsThe responses of 383 participants were analysed and the results revealed that providing risk probability increased their willingness to take medication (3%), whereas the estimated risk probability by the participants was 28.7% on an average when no numerical probability was provided. Moreover, when risk probability was provided in a benefit/risk order, the willingness to take medication increased than in the risk/benefit order.ConclusionsThe participants’ willingness to take medication improved when the pharmacists provided risk probability; this helped participants comprehend that the risk probability was lesser than their assumptions. Moreover, the participants’ attention to the numeric information in medication counselling can be elicited by the peak-end rule. The findings from the hypothetical scenarios employed in this study merit further testing in real-life situations for clinical application.
Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways
Authors: Zhang Min , Zhang Juan , Zhu Qi-Meng , Zhao Wen-Yu , Lv Xia , Yi Jing , Huo Xiao-Kui , Wang Mi-Jia , Sun Cheng-Peng 
Published: January 2023

Abstract

Objectives
To investigate the protective effect and underlying mechanism of Inula japonica (TEIJ) in the treatment of acute lung injury (ALI).

Methods
Protective effects of TEIJ in the inflammation and oxidative stress were studied in lipopolysaccharide (LPS)-induced ALI mice. Meanwhile, Western blot and real-time qPCR were carried out to investigate the underlying mechanism of TEIJ for ALI as well as immunohistochemistry.

Key findings
TEIJ significantly alleviated the course of ALI via suppressing the interstitial infiltrated inflammatory cells, the increase of inflammatory factors and the decrease of anti-oxidative factors. TEIJ inactivated the MAPK/NF-κB signalling pathway to suppress the transcription of its downstream target genes, such as TNF-α, IL-6, etc. Meanwhile, TEIJ activated the Keap1/Nrf2 signalling pathway to regulate expression levels of Nrf2 and its target proteins. The results of LC-QTOF-MS/MS indicated potential active constituents of I. japonica, terpenoids and flavonoids. Additionally, terpenoids and flavonoids synergistically alleviated LPS-induced ALI depending on MAPK/NF-κB and Keap1/Nrf2 signalling pathways.

Conclusion
I. japonica could be considered a potential agent to treat ALI via regulating the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.
Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles
Authors: Stepanenko Valeriy , Kaprin Andrey , Ivanov Sergey , Shegay Peter , Bogacheva Viktoria , Sato Hitoshi , Shichijo Kazuko , Toyoda Shin , Kawano Noriyuki , Ohtaki Megu , Fujimoto Nariaki , Endo Satoru , Chaizhunusova Nailya , Shabdarbaeva Dariya , Zhumadilov Kassym , Hoshi Masaharu 
Published: January 2023

Abstract
Manganese-56 (56Mn) was one of the dominant neutron-activated radionuclides during the first hours following the atomic-bombing of Hiroshima and Nagasaki. The radiation spectrum of 56Mn and the radiation emission from excited levels of 56Fe following 56Mn beta-decay include gamma-quanta, beta-particles, Auger electrons and X-rays. The dispersion of neutron activated 56Mn in the air can lead to entering of radioactive microparticles into the lungs. The investigation of spatial microdistribution of an internal dose in biological tissue exposed to 56Mn is an important matter with regards to the possible elevated irradiation of the lung alveoli and alveolar ducts. The Monte Carlo code (MCNP-4C) was used for the calculation of absorbed doses in biological tissue around 56Mn dioxide microparticles. The estimated absorbed dose has a very essential gradient in the epithelium cells of lung alveoli and alveolar duct: from 61 mGy/decay on the surface of simple squamous cells of epithelium to 0.15 mGy/decay at distance of 0.3 μm, which is maximal cell thickness. It has been concluded that epithelial cells of these pulmonary microstructures are selectively irradiated by low-energy electrons: short-range component of beta-particles spectrum and Auger electrons. The data obtained are important for the interpretation of biological experiments implementing dispersed neutron-activated 56Mn dioxide powder.
Tooth enamel ESR dosimetry for Hiroshima ‘black rain’ zone residents
Authors: Zhumadilov Kassym , Ivannikov Alexander , Stepanenko Valeriy , Toyoda Shin , Kazymbet Polat , Kaprin Andrey , Ivanov Sergey , Shegay Peter , Endo Satoru , Hoshi Masaharu 
Published: January 2023

Abstract
Electron spin resonance (ESR) dosimetry was applied to human tooth enamel in order to obtain individual absorbed doses for victims of the Hiroshima bomb who lived in the ‘black rain’ area. The so-called ‘black rain’ fell in the form of precipitation on the western part of Hiroshima city and the northwestern suburbs within a few hours after the explosion of the atomic bomb on 6 August 1945, and exposed the population in this area. Only three tooth samples were collected from this area. Since the teeth were located at positions 1, 2 and 4, only the lingual portion was used for the analysis. The results showed that the excess dose after subtracting natural radiation for one (position 4; hh1) was background, for the second (position 2; hh2) it was 133 mGy, and for the other (position 1; hh3) it was 243 mGy. Based on these results, we further investigated the radiation dose attributed to dental X-rays and head CT scan. Such dose of the hh3 radiographic examination was estimated to be 57–160 mGy, which implies an additional exposure around 135 mGy after subtraction. On the other hand, the dose data of hh1 after subtracting dental X-rays was negative. This may mean that such additional doses are an overestimation. In addition, the effect of sunlight should be considered, which is the same direction of overestimation. As a result, the residual dose of 140 mGy suggests the inclusion of radiation from the ‘black rain.’
External dose estimates of laboratory rats and mice during exposure to dispersed neutron-activated 56Mn powder
Authors: Stepanenko Valeriy , Sato Hitoshi , Fujimoto Nariaki , Shichijo Kazuko , Toyoda Shin , Kawano Noriyuki , Endo Satoru , Kaprin Andrey , Ivanov Sergey , Shegay Peter , Petukhov Alexey , Kolyzhenkov Timofey , Bogacheva Victoria , Chaizhunusova Nailya , Shabdarbaeva Dariya , Zhumadilov Kassym , Hoshi Masaharu 
Published: January 2023

Abstract
Estimates of external absorbed dose in experimental animals exposed to sprayed neutron-activated 56Mn powder are necessary for comparison with internal absorbed doses estimated under the same exposure conditions, which is required for a correct interpretation of the observed biological effects. It has been established that the measured dose of external absorbed dose as a result of gamma irradiation range 1–15 mGy, which is order of magnitude less than the maximal dose of internal gamma and beta irradiation of the whole body of the same experimental animals irradiated under the same conditions: according to the available literature data, the maximal values ​​of absorbed dose of internal gamma-beta irradiation of the whole body are in the range of 330 mGy–1200 mGy for mice and 100 mGy–150 mGy for rats. It is concluded that under the conditions of experiments with dispersed neutron-activated powder 56MnO2, internal gamma-beta irradiation of experimental animals is the main factor of radiation exposure compared to external gamma irradiation.
Solid cancer mortality risk among a cohort of Hiroshima early entrants after the atomic bombing, 1970–2010: implications regarding health effects of residual radiation
Authors: Otani Keiko , Ohtaki Megu , Yasuda Hiroshi 
Published: January 2023

AbstractThere are two types of exposure to atomic bomb (A-bomb) radiation: exposure to initial radiation released at the time of the detonation of the bomb, and exposure to residual radiation, which remains afterwards. Health hazards caused by exposure from residual radiation have not yet been clarified. The purpose of our study was to reveal the relationships between mortality risk from solid cancer and residual radiation based on data from the early entrants to Hiroshima. It is hard to identify the individual residual radiation doses. However, these are assumed to depend on the date of entry and the entrants’ behavior. Individual behavior is thought to be closely related to gender and age at exposure. We investigated a cohort of 45 809 individuals who were living in Hiroshima Prefecture on 1 January 1970 and were registered on the Database of Atomic Bomb Survivors as entrants after the bombing. Poisson regression methods were used to estimate excess relative risks (ERR) with data cross-classified by sex, age at entry, and date of entry. In males in their 20s, 30s, and 40s at entry and in females less than 10 years old and in their 40s at entry, solid cancer mortality risks were significantly higher among persons who entered the city on the day of the bombing than those who entered three or more days later. With adjustments for the age-dependent sensitivities to radiation exposure, it was extrapolated that middle-aged people who entered the city on the day of the bombing were exposed to higher levels of residual radiation than younger people.
External exposure assessment in the Fukushima accident area for governmental policy planning in Japan; Part 2. Matters to be attended for assessments of external exposure
Authors: Yoshimura Kazuya , Sanada Yukihisa , Sato Rina , Nakayama Mariko , Tsubokura Masaharu 
Published: January 2023

AbstractAfter the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, individual exposure doses to residents have been assessed by many municipalities, governments and research institutes. Various methods including measurements with personal dosimeters and simulations have been used for this evaluation depending on purposes, but the information of assessments and methods has not been systematically organized. A comprehensive review of the knowledge and experiences of individual exposure doses assessments accumulated so far and understanding the characteristics of the assessment methods will be very useful for radiation protection and risk communication, following to governmental policy planning. We reviewed the efforts made by the Japanese government and research institutes to assess radiation doses to residents after the FDNPS accident in Part 1. On the other hand, each method of assessing individual exposure doses includes uncertainties and points to be considered for the appropriate assessment. These knowledge and experiences are important for the assessment implementation and applying the assessment results to the governmental policy planning, and are summarized in Part 2 of this article.
Relationship between haematological data and radiation doses of TEPCO workers before and after the FDNNP accident
Authors: Okazaki Ryuji , Kohzaki Masaoki , Kai Michiaki , Jiang Ying , Kubo Tatsuhiko , Ootsuyama Akira , Sado Toshihiko , Suzuki Katsunori , Tateishi Seiichiro , Mori Koji 
Published: January 2023

AbstractWe evaluated the correlation between radiation dose and the medical examination data of Tokyo Electric Power Company Holdings, Inc (TEPCO) employees working during the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident in 2011. This study included 2164 male TEPCO workers who received periodic medical examinations from March 2006 to January 2013. First, we conducted log-linear regression analyses using the haematological data of 585 emergency workers and confounding factors to examine the effect of internal radiation exposure in March 2011. Since external radiation exposure was a major influence, we then evaluated the correlation between both internal and external radiation dose and the haematological data of 1801 emergency workers and confounding factors before and after the accident. Among 585 workers, internal radiation exposure in March 2011 alone was mainly due to thyroid doses (0.1-10 Gy) but not to bone marrow (BM) doses (0.01-1 mGy). Compared to before and after the accident, we found that the levels of monocytes, eosinophils (Eos) and basophils increased slightly, whereas the frequency of smoking and alcohol consumption decreased substantially. External dose exposure was positively correlated with haemoglobin (Hb), red blood cell and Eos but negatively correlated with age, haematocrit and frequency of alcohol consumption. Among these variables, Hb exhibited the strongest correlation with external dose. Regarding the correlation with Hb, although there is a possibility that confounding factors other than exposure were not evaluated, our findings on emergency workers can serve as a reference for the evaluation of health conditions during the emergency period of future nuclear-related accidents.
KRT13is upregulated in pancreatic cancer stem-like cells and associated with radioresistance
Authors: Takenaka Wataru , Yokoyama Yuhki , Ikehata Katsuya , Kouda Shihori , Hirose Haruka , Minami Kazumasa , Hamada Yoshinosuke , Mori Seiji , Koizumi Masahiko , Yamamoto Hirofumi 
Published: January 2023

AbstractPancreatic cancer is one of the most aggressive cancers and the seventh leading cause of cancer-associated death in the world. Radiation is performed as an adjuvant therapy as well as anti-cancer drugs. Because cancer stem-like cells (CSCs) are considered to be radioresistant and cause recurrence and metastasis, understanding their properties is required for the development of novel therapeutic strategies. To investigate the CSC properties of pancreatic cancer cells, we used a pancreatic CSC model, degron (++) cells, which have low proteasome activity. Degron (++) cells displayed radioresistance in comparison with control cells. Using Ribonucleic acid (RNA) sequencing, we successfully identified KRT13 as a candidate gene responsible for radioresistance. Knockdown of KRT13 sensitized the degron (++) cells to radiation. Furthermore, a database search revealed that KRT13 is upregulated in pancreatic cancer cell lines and that high expression of KRT13 is associated with poorer prognosis. These results indicate that a combination therapy of KRT13 knockdown and radiation could hold therapeutic promise in pancreatic cancer.
Analysis of differentially expressed genes on human X chromosome harboring large deletion induced by X-rays
Authors: Hirose Eri , Yokoya Akinari , Kawamura Kasumi , Suzuki Keiji 
Published: January 2023

AbstractWe examined here normal human cells with large deletions encompassing the hypoxanthine-phosphoribosyltransferase 1 (HPRT1) gene on X chromosome. Expression levels of genes on X chromosome were analyzed by microarray and RT-qPCR method, and differentially expressed genes (DEGs) were extracted. We found that DEGs were not limited to the genes flanking deleted regions but spread over the entire X chromosome. Interestingly, the gene regulation patterns were similar to a large extent among independent clones that have similar-sized large deletions involving the HPRT1 gene. Thus, it is indicated that an impact of large deletion on possible epigenetic transcriptional regulation is not limited to the regions proximal to the deletion region.
Salvage craniospinal irradiation for recurrent intracranial germinoma: a single institution analysis
Authors: Kanamori Masayuki , Shimoda Yoshiteru , Umezawa Rei , Iizuka Osamu , Mugikura Shunji , Suzuki Kyoko , Ariga Hisanori , Jingu Keiichi , Saito Ryuta , Sonoda Yukihiko , Kumabe Toshihiro , Tominaga Teiji 
Published: January 2023

AbstractThis study investigated the effectiveness and safety of low-dose salvage craniospinal irradiation (CSI) for recurrent germinoma. We retrospectively reviewed long-term tumor control and late adverse effects in 15 recurrent germinoma patients treated at our hospital between 1983 and 2019. Following the first recurrence of germinoma, seven were treated with 24–30 Gy of salvage CSI, three underwent non-CSI, and five were treated with only chemotherapy. CSI achieved a significantly better recurrence-free survival rate after the first recurrence compared to other strategies (100% vs 33%, p &lt; 0.001: log-rank test). To evaluate the safety of salvage CSI, we assessed the outcomes at the final follow-up of seven patients who received salvage CSI at first recurrence and three patients who received salvage CSI at second recurrence. The median follow-up period was 220 months after initial treatment. Five patients who received 40–50 Gy of radiation therapy or underwent multiple radiation therapy before salvage CSI were classified into Group A, whereas five patients treated with platinum-based chemotherapy and 24–32 Gy of radiation therapy to the primary site, whole ventricle, or whole brain were classified into Group B. In Group A, one had endocrine dysfunction and the other had visual dysfunction. None were socially independent. Meanwhile, in Group B, no endocrine or visual dysfunction was found, and three patients were socially independent. Salvage CSI achieved excellent tumor control in recurrent germinoma and was safe in patients initially treated with low-dose radiation therapy and chemotherapy.
The successful treatment of Lamellar Ichthyosis—a plastic surgeons perspective
Authors: Johnson Miguel , Mowatt Caleisia , Scott Kimberley 
Published: January 2023

Abstract
Congenital Ichthyosis represents a very rare group of congenital skin disorders characterized by some degree of scaling and thickening of the stratum corneum with skin inflammation. Severe forms such as Harlequin and Lamellar forms may present with limb and organ compromise, respectively. Patients with Lamellar subtype presents with severe ectropion which may lead to corneal ulceration, rupture and blindness. Treatment includes a multidisciplinary approach allowing for early intervention and treatment, which optimize the outcomes. The timing for intervention is not clearly defined in the literature. This is most likely due to a paucity in data due to the relative infrequency in these conditions. However, using principles similar to early treatment of ectropion in burnt patients may be employed. A case of Lamellar Ichthyosis that presented to our outpatient clinic which was successfully managed with early ectropion release and full thickness skin graft is discussed.
Bayesian Graphical Entity Resolution using Exchangeable Random Partition Priors
Authors: Marchant Neil G , Rubinstein Benjamin I P , Steorts Rebecca C 
Published: January 2023

AbstractEntity resolution (record linkage or deduplication) is the process of identifying and linking duplicate records in databases. In this paper, we propose a Bayesian graphical approach for entity resolution that links records to latent entities, where the prior representation on the linkage structure is exchangeable. First, we adopt a flexible and tractable set of priors for the linkage structure, which corresponds to a special class of random partition models. Second, we propose a more realistic distortion model for categorical/discrete record attributes, which corrects a logical inconsistency with the standard hit-miss model. Third, we incorporate hyperpriors to improve flexibility. Fourth, we employ a partially collapsed Gibbs sampler for inferential speedups. Using a selection of private and nonprivate data sets, we investigate the impact of our modeling contributions and compare our model with two alternative Bayesian models. In addition, we conduct a simulation study for household survey data, where we vary distortion, duplication rates and data set size. We find that our model performs more consistently than the alternatives across a variety of scenarios and typically achieves the highest entity resolution accuracy (F1 score). Open source software is available for our proposed methodology, and we provide a discussion regarding our work and future directions.
Differential impact of crown rust (Puccinia coronata) infection on photosynthesis and volatile emissions in the primary host Avena sativa and the alternate host Rhamnus frangula
Authors: Sulaiman Hassan Y , Runno-Paurson Eve , Kaurilind Eve , Niinemets Ülo 
Published: January 2023

Abstract
Rust infection results in decreases in photosynthesis and stress volatile emissions, but how these changes vary among host species has not been studied. We demonstrated that the impact of the obligate biotrophic fungus, Puccinia coronata f. sp. avenae, on foliage physiological processes is stronger in the primary host, Avena sativa (cultivated oat), than in the alternate host, Rhamnus frangula (alder buckthorn). Photosynthesis decreased with increasing percentage of damaged leaf area (DA) in both species, but reductions were greater in A. sativa. In A. sativa, photosynthetic reductions resulted from reductions in stomatal conductance and photosynthetic capacity; in R. frangula, reductions were due to reduced capacity. Infection reduced photosynthetic biomass and key nutrients in A. sativa, but not in R. frangula. In A. sativa, stress-elicited emissions (methyl jasmonate, green leaf volatiles, long-chain saturated aldehydes, mono- and sesquiterpenes, benzenoids, and carotenoid breakdown products) increased with increasing DA from 0% to 40%, but decreased with further increases in DA. In R. frangula, volatile emissions were slightly elicited but, surprisingly, constitutive isoprene emissions were enhanced. Different hosts had characteristic volatile fingerprints, indicating differential activation of biochemical pathways. Fungal-elicited reductions in photosynthesis scale uniformly with stress severity. In the sensitive host, biphasic scaling of volatiles indicates that heavy spread of chlorosis/necrosis leads to an overall cessation of physiological functioning.
Manipulation of plant RNA biology by geminiviruses
Authors: Wang Liping , Lozano-Durán Rosa 
Published: January 2023

AbstractViruses are intracellular parasites that have evolved to effectively manipulate the cells they infect. As a result of the viral infection, multiple cellular processes are altered, suppressed, or redirected, partially due to the viral co-option of the host’s molecular machinery. RNA biology plays a central role in virus–host interactions, since it is at the basis of viral gene expression, splicing of viral transcripts, anti-viral RNA silencing, and—at least in the case of RNA viruses—genome replication, and therefore is heavily targeted by viruses. The plant DNA geminiviruses, causal agents of devasting diseases in crops worldwide, are no exception, and RNA processing is tightly entrenched in their infection cycle. In this review, we will discuss the relevance of the manipulation of RNA biology by geminiviruses for a successful viral infection and the underlying molecular mechanisms, and suggest some of the multiple remaining open questions in this field.