bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion
Authors: Bai Ruoxue , Liang Baoyan , Guo Yaotao , Liu Wei , Wen Zhuoyue , Wang Zhantong , Zhang Yu , Du Jing , Song Yajuan , Yu Zhou , Ma Xianjie 
Published: January 2025

ABSTRACTBackgroundTissue expansion is a widely employed technique in reconstructive surgery aimed at addressing considerable skin defects. Nevertheless, matters like inadequate expansion capability and the potential for skin breakage due to the fragility of the expanded tissue present notable hurdles in enhancing skin regeneration during this process. Angiotensin‐converting enzyme 2 (ACE2) is recognized for its essential role in facilitating tissue renewal and regeneration. However, its precise impact on skin renewal during tissue expansion remains underexplored. This study seeks to elucidate ACE2's contribution to skin regeneration, specifically examining its role in collagen synthesis.MethodsThis study evaluated the expression and distribution of ACE2 in expanded skin using samples derived from both rats and human patients. Additionally, we investigated ACE2 expression in stretched keratinocytes in vitro. ACE2 knockout keratinocytes were transfected with small interfering RNA (siRNA) and cocultured with fibroblasts to observe fibroblast proliferation and migration. MLN‐4760 was utilized to inhibit the ACE2 enzymatic activity. Additionally, we analyzed parameters such as the size of expanded skin, dermal thickness, and the levels of collagen I (COL I), collagen III (COL III), and transforming growth factor β (TGF‐β) to elucidate the role of ACE2 in the context of expanded skin.ResultsThe thinning of the expanded dermis was linked with elevated ACE2 expression. Enzymatic activity and ACE2 expression were both increased by mechanical stress. Additionally, ACE2 utilized Ang II to activate the migration and proliferation of human dermal fibroblasts. In vivo, the ACE2 inhibitor MLN‐4760 promoted skin regeneration and reduced dermal thinning by elevating COL I, COL III, and TGF‐β during expansion.ConclusionsThis finding suggest that mechanical stretch increases ACE2 expression, which in turn promotes the regeneration of expanded skin. The basis for using ACE2 in clinical settings to increase tissue expansion efficacy is provided by this work.
How Do Nurses Decide on Missed Nursing Care? A Grounded Theory Study of Grassroots Arrangement of Nursing Care
Authors: Guo Xiaoying , Li Hongxia , Zou Qian , Cao Yanjun , Lin Taoyu , Zhang Mingji 
Published: January 2025

ABSTRACTAimsTo explore the complete decision‐making process and action logic of nurses making autonomous decisions that result in missed nursing care.BackgroundThe complex characteristics of patients in Intensive Care Units place higher demands on the allocation of nursing resources, as well as on the professional skills, resilience and ethics of nursing staff. Preventing missed nursing care is particularly crucial in Intensive Care Units.DesignA theory construction qualitative study using grounded theory.MethodsSemistructured face‐to‐face interviews were conducted with 20 nurses, including three head nurses and 17 bedside nurses. Head nurses provided insights into counselling and management practices.ResultsThe theoretical model of nurses' decision‐making processes comprise four strategies: setting priorities, seeking help, delaying nursing care and omitting nursing care. The latter two constitute missed nursing care. Inadequate staffing, task urgency and negative emotions can lead to omitting nursing care.ConclusionsThis study proposes an original concept: grassroots arrangement of nursing care (GANC). Grassroots arrangement of nursing care includes the autonomous and adaptive decision‐making process used by bedside nurses to optimise workflow in busy environments. It includes specific strategies and quality implications, enabling a nuanced balance between limited nursing resources, increasing patient needs and maintaining the best possible quality of care.Relevance to Clinical PracticeNursing managers should consider the dual aspects of grassroots arrangement of nursing care, support nurses' grassroots autonomy and streamline decision‐making processes.Reporting MethodThis study follows the Consolidated Criteria for Reporting Qualitative Studies (COREQ).Patient or Public ContributionNo patient or public contribution.
Development and Validation of the Family and Community Nursing Advanced Practice Scale
Authors: Unsworth John , Oldman Crystal , Atkinson Joanne , Comparcini Dania , Simonetti Valentina , Cicolini Giancarlo , Mikkonen Kristina , Tomietto Marco 
Published: January 2025

ABSTRACTAimTo develop and test a Family and Community Nursing—Advanced Practice Scale.DesignA cross‐sectional and methodological scale validation design, following classical test theory.MethodsThree phases, the first of which involved scale development, including item generation. Phase two assessed the content validity index. The third phase involved a cross‐sectional survey to establish construct validity, content validity, internal consistency reliability, and exploratory factor analysis.ResultsThe Family and Community Nursing Advanced Practice Scale has good construct validity, with the final scale consisting of 5 domains and 27 items. This was confirmed by both the exploratory and confirmatory factor analysis. The Cronbach's Alpha is very good, suggesting that the scale is reliable. When comparing family practice advanced practice nurses with those working in the community, the results show that scores are similar except for clinical reasoning and health promotion, which consistently showed statistically significant higher scores among the family practice nurses. While community nurses scored higher on items in the leading practice domain reflecting their role in a wider team of nurses.ConclusionThis study developed and psychometrically tested the Family and Community Nursing—Advanced Practice Scale. The scale has good reliability, and analysis of the construct validity reveals five domains of advanced practice among this practitioner group.Implications for the ProfessionThe study suggests that advanced practice nurses working in community roles perform similar activities to those working in family practice in the United Kingdom. However, activity related to research was less evident.ImpactThe study examined the scope of the advanced practice nurse role in family and community nursing. The study illustrated practice across five domains: clinical care, leading practice, clinical reasoning, health promotion, and ethics. The family practice and wider community roles were largely homogenous, with only two items showing a statistically significant difference in scores.Reporting MethodSTROBE guidelines for cross‐sectional studies.Patient or Public ContributionNo patient or public contribution.
Two sides of a coin: The relationship between work autonomy and childbearing
Authors: Osiewalska Beata , Matysiak Anna 
Published: January 2025

AbstractObjectiveThis article investigates the under‐researched role of work autonomy, encompassing the control over how, when and where to work, for both the entry into parenthood and the transition to a second child across different social strata in the United Kingdom.BackgroundOver the past three decades, employees have gained increased work autonomy, a trend expected to persist with technological advancements. Work autonomy substantially affects the combination of paid work and family life. But its multifaceted impact on workers' fertility behavior, especially across different educational levels, has remained unclear.MethodThe study employs a sample of partnered women and men from UKHLS 2009–2019 data. Latent Class Analysis incorporates the three dimensions: job, schedule, and workplace controls to identify distinct patterns of work autonomy, which serve as key explanatory variables in event‐history models for first and second‐birth risks.ResultsWe find no relationship between work autonomy and fertility behavior for men. For highly educated women, work autonomy is negatively related to the transition to motherhood, but positively associated with the risk of having a second child. For less educated women, the relationship between work autonomy and childbearing ranges from negative to non‐significant, depending on the specific dimension of autonomy.ConclusionThe study highlights the intricate link between work autonomy and fertility and emphasizes important social stratification in the impact of autonomy on individuals. Further research is needed to unravel the observed duality, that is, understanding the challenges posed by work autonomy for fertility, especially among childless women and those less educated.
Understanding familial resemblance of fingerprints: Forensic and anthropological aspects
Authors: Rana Akansha , Siwan Damini , Vashisht Akashdeep , Krishan Kewal 
Published: January 2025

AbstractAlthough fingerprint analysis is widely used in forensic science investigations for personal identification, this unique feature of human beings always has something new to reveal. Genetic factors heavily influence fingerprint formation during embryonic development; therefore, there is a possibility of resemblance or inheritance of fingerprint patterns among the family members. The main objective of the present study is to understand the resemblance of fingerprint patterns among close family members, that is, father, mother, and their children. The study included 134 participants from 20 families of north India. Fingerprints from all the participants were obtained and analyzed for similarities and differences in pattern types between the parents and children to assess their strength of association. The results indicate a significant association (p‐value < 0.05) between the fingerprint patterns of the first and second child and their mother. However, no such significance was found between the father and the children. The present study shows that there is a 40% chance of inheritance of fingerprint patterns from the mother to both the children, while the father shows 30% similarity with the first child and only 10% similarity with the second child. Whereas, only 20% of similarity was found among both the siblings. The findings of this preliminary study suggest that in certain circumstances such as mass disasters, cold cases, paternity disputes, missing persons, and so forth, forensic scientists may help to establish connections and corroborate familial relationships by studying the fingerprint patterns of family members.
Anatomical and morphological variations in the dorsal root ganglion: Technical implications for chronic pain treatment with neuromodulation—A systematic review
Authors: Acevedo‐Gonzalez Juan Carlos , Ariza‐Piñeros Carlos Felipe , Vega‐Corredor José Manuel 
Published: January 2025

AbstractObjectivesIn the last 20 years, we have seen the flourishing of multiple treatments targeting the dorsal root ganglion (DRG) for pain. However, there is concern regarding the variation in the location of the DRG, which could influence the long‐term clinical outcomes. The aim of this work was to determine the exact position of the DRG in the spine and propose a pre‐surgical planning.Materials and MethodsA systematic search was conducted following the principles recommended by PRISMA. Search terms “ganglia,” “DRG,” “dorsal root ganglia, anatomy,” “radiological,” “neuromodulation,” “dorsal root ganglion stimulation” (PubMed, Scopus, Medline, Web of Science, and Embase) were identified 177 articles and subjected to the selection criteria (inclusion/exclusion) based on the independent review of the abstracts.ResultsEighteen articles were selected (seven anatomical dissections on cadavers, five radiological studies, and six narrative reviews).DiscussionPercutaneous procedure targeting the DRG for the treatment of chronic pain requires preoperative planning independent to the study of the etiology of pain. The DRG should be typified using magnetic resonance imaging. We propose a preoperative evaluation scale based on four specific items: A—position in the vertebral canal, B—position of the DRG within the foramen, C—number of ganglia in the root, and D—ratio (proportion) of foramen/DRG.ConclusionPercutaneous treatments for chronic pain directed at the DRG are effective. Clinical outcomes depend of good preoperative planning that allows for optimizing its effects. We propose a DRG morphology evaluation scale useful for the planning process prior to any treatment directed at the ganglion.
Breakdown of the Kasha–Vavilov's rule in low‐symmetry porphyrazines: Ultrafast intersystem crossing via high vibronic state
Authors: Tarakanov Pavel A. , Kozlov Alexei V. , Simakov Anton O. , Goryachev Nikolay S. , Pushkarev Victor E. 
Published: January 2025

AbstractRecently (Photochem Photobiol. 2023;100:1277–1289. doi:10.1111/php.13898), we described the anti‐Kasha effect in tribenzo‐6H‐1,4‐diazepinoporphyrazins with C2v symmetry, where the ultrafast spin changes successfully compete with the internal conversion. In this study, we show the presence of this effect in 2 (3),9 (10),16(17),23(24)‐tetra‐tert‐butyl‐29H,31H‐phthalocyanine (1) and 1,4‐di‐[2‐(2‐methoxyethoxy)ethoxy]‐29H,31H‐phthalocyanine (2), which also possess reduced molecular symmetry and do not bear 6H‐1,4‐diazepine fragments. The anti‐Kasha effect in 1 and 2 supplemented by Mg(II) tribenzo‐6H‐1,4‐diazepinoporphyrazinates 3 and 4 exhibits a close‐to‐linear dependence on energy gap value between the zero vibrational levels of two lowest singlet excited states S10 and S20 (these states are degenerate in D4h symmetry) and enhances with increase. The theoretical kinetic model of excited state dynamics, which takes into account the observed effects and follows Fermi's golden rule, predicts the presence of an additional excited state with enhanced spin‐orbit coupling compared to S10, S20 and the corresponding triplet states, which is not predicted by TDDFT calculations in the Born–Oppenheimer approximation. The combination of the above indicates that the key role in the observed anti‐Kasha effect and the mechanism of dissipation of the excited state in porphyrazines and their analogs is played by vibronic excited states, which requires theoretical research methods beyond the Born–Oppenheimer approximation.
Response of native (Quercus robur L.) and alien (Quercus rubra L.) species to water stress and nutrient input in European temperate ecosystems
Authors: Rolando Morena , Ganugi Paola , Secchi Francesca , Said‐Pullicino Daniel , Bonifacio Eleonora , Celi Luisella 
Published: January 2025

AbstractDrought and nutrient‐poor soils can increase the invasive potential of non‐native species, further changing the ecosystems they invade. The high adaptability of these alien species, especially in their efficient use of resources, improves their resilience against abiotic stress. Here, we evaluated the response of the North American Quercus rubra L. (RO) and the European Quercus robur L. (EO) oak species to drought and nutrient scarcity as single and combined factors. Both species were grown under well‐watered or alternating short dry‐wet phases, with or without the addition of phosphorous (P) and labelled nitrogen (N). Leaf gas exchanges and stem water potential were measured; moreover, leaf chemical characterization was carried out. Under concurrent low fertility and drought, both species reduced gas exchanges and stem water potential, although RO recovery was faster than EO. Nutrient inputs did not modulate RO's physiological response; however, P supply increased its uptake of the more available N forms (15NH415NO3). The different leaf contents of N and P demonstrated that EO has lower nutrient use efficiency compared to RO. Nevertheless, P addition significantly mitigated the drought effects on EO, highlighting the crucial role of this nutrient in aiding EO's recovery under stress conditions. RO invasive potential may be linked to its superior adaptability and resource‐use efficiency under combined abiotic stress. Nevertheless, EO competitiveness can be improved through targeted nutrient management.
Enriched Pitman–Yor processes
Authors: Rigon Tommaso , Petrone Sonia , Scarpa Bruno 
Published: January 2025

AbstractBayesian non‐parametrics has evolved into a broad area encompassing flexible methods for Bayesian inference, combinatorial structures, tools for complex data reduction, and more. Discrete prior laws play an important role in these developments, and various choices are available nowadays. However, many existing priors, such as the Dirichlet process, have limitations if data require nested clustering structures. Thus, we introduce a discrete non‐parametric prior, termed the enriched Pitman–Yor process, which offers higher flexibility in modeling such elaborate partition structures. We investigate the theoretical properties of this novel prior and establish its formal connection with the enriched Dirichlet process and normalized random measures. Additionally, we present a square‐breaking representation and derive closed‐form expressions for the posterior law and associated urn schemes. Furthermore, we demonstrate that several established models, including Dirichlet processes with a spike‐and‐slab base measure and mixture of mixtures models, emerge as special instances of the enriched Pitman–Yor process, which therefore serves as a unified probabilistic framework for various Bayesian non‐parametric priors. To illustrate its practical utility, we employ the enriched Pitman–Yor process for a species‐sampling ecological problem.
Conceptual and Evidence Update on Incidental Physical Activity: A Scoping Review of Experimental and Observational Studies
Authors: Reyes‐Molina Daniel , Zapata‐Lamana Rafael , Nazar Gabriela , Cigarroa Igor , Ruiz Jonatan R. , Parrado Eva , Losilla Josep‐Maria , Celis‐Morales Carlos 
Published: January 2025

ABSTRACTPromoting incidental physical activity (IPA) can help reduce sedentary lifestyles and physical inactivity levels in the population. However, there is heterogeneity in the definition of IPA, and studies have yet to synthesize the empirical findings on this topic. This review aimed to (1) Synthesize the definitions of the IPA used in the scientific literature, (2) Identify the behaviors part of the IPA, and (3) Synthesize the main findings on IPA. The review followed PRISMA guidelines. A systematic search was performed in July 2023, and an update was made in February 2024 in the CINAHL databases by EBSCOhost, Cochrane Library, Pubmed, ScienceDirect, Scopus, and Web of Science. The search phrase was (“incidental physical activity” OR “incidental physical activity of daily living” OR “incidental movement” OR “vigorous intermittent lifestyle physical activity” OR “VILPA” OR “physical activity of daily living”). Fifty‐five studies were included, with non‐experimental (40), experimental (12), qualitative studies (2), and mixed design (1). Ten different terms for IPA were identified, and a conceptual definition was included in 33 articles. Behaviors measured as part of the IPA were reported in 41 articles. These definitions describe unstructured, unplanned, and unintentional physical activities of daily living that are performed as a by‐product of an activity with a different primary purpose during free or occupational time and without specific fitness, sport, or recreation goals. Include light and vigorous intensities ranging from short sessions of < 1 min to prolonged ones. They include home activities, self‐care, gardening, occupation, active transportation, and walking. Furthermore, evidence on IPA suggests an association with a lower risk of all‐cause mortality. The findings of this review contribute to the updated study of IPA. Advances in data processing methods are needed to capture the diversity of behaviors and deepen the understanding of IPA.
A First Proposal for Fatigue Life Prediction of Carbon Black Filled Natural Rubber at Different Temperatures With an Artificial Neural Network
Authors: Robin E. , Le Cam J.‐B. , Delahaye G. , Ruellan B. , Di Cesare N. , Canévet F. 
Published: January 2025

ABSTRACTIn this paper, the fatigue life prediction of a carbon black filled natural rubber was carried out using an artificial neural network. A wide range of loading ratios were considered under relaxing and non‐relaxing loading conditions in order to fully describe the fatigue response, especially the lifetime reinforcement. As the reinforcement is generally assumed to be due to a highly thermosensitive phenomenon, namely, the strain‐induced crystallisation, tests were performed at three different temperatures. The lifetime criterion was defined in terms of stiffness loss. An original pedagogically based training approach allowed us to satisfactorily predict the fatigue response from limited experimental databases. The method provides Haigh diagrams at temperatures not previously tested and predicts well the reinforcement decrease with the temperature, then saving a considerable number of tests. The results show that the approach finds promising results and opens a new way for reducing fatigue tests of elastomers.
A novel approach to decannulation of a tracheostomy tube using a 1‐way speaking valve after upper airway trauma in 2 dogs
Authors: Kastenholz Victoria N. P. , Wolf Jacob , Bernhard Christa L. 
Published: January 2025

AbstractObjectiveTo describe a novel approach to tracheostomy management in dogs with upper airway trauma.Case Series SummaryTwo dogs with upper airway trauma presented to an emergency department and required immediate intubation. To minimize sedation time, tracheostomy tubes were placed in both dogs. A stepwise approach to decannulation was initiated, with both dogs receiving a 1‐way speaking valve to facilitate a gradual approach to decannulation.New or Unique Information ProvidedThis is the first report of a 1‐way speaking valve being used in the management of tracheostomy tubes in dogs.
Retrospective evaluation of dexamethasone for treatment of suspected critical illness‐related corticosteroid insufficiency in dogs with septic shock (2017–2022): 60 cases
Authors: Gardiner Destinee , Harris Bradley 
Published: January 2025

AbstractObjectiveTo retrospectively compare and report vasopressor duration and mortality of septic dogs with hypotension refractory to vasopressor administration (presumed critical illness‐related corticosteroid insufficiency [CIRCI]) treated with or without dexamethasone sodium phosphate (DxSP).DesignRetrospective study (2017–2022).SettingTertiary referral and teaching hospitals.AnimalsSixty client‐owned dogs with confirmed or presumed sepsis and vasopressor‐resistant hypotension. Hypotension was defined as systolic arterial pressure < 90 mm Hg or MAP < 65 mm Hg. Vasopressor resistance was defined as hypotension despite therapy with moderate‐ to high‐dose vasopressors (> 0.5 µg/kg/min of norepinephrine IV).InterventionsNone.Measurements and Main ResultsTwenty‐six dogs received DxSP (DxSP group, 0.002–0.39 mg/kg IV, variable frequency), and 34 dogs did not receive a glucocorticoid (non‐DxSP group). The median time to vasopressor discontinuation was 20 hours (interquartile range [IQR]: 21; n = 6) in the DxSP group and 27 hours (IQR: 11; n = 5) in the non‐DxSP group. In the DxSP group, 23% (6/26) of dogs survived to discharge compared with 15% (5/34) of dogs in the non‐DxSP group, which was not significantly different (relative risk: 0.90, 95% confidence interval: 0.70–1.16; P = 0.41). There was no significant difference between the 2 groups in time from vasopressor administration to weaning in dogs that survived to discharge (P = 0.43). The median time from steroid administration to vasopressor wean was 15 hours (IQR: 19; n = 6), and the median time from steroid administration to sustained normotension (a systolic blood pressure > 90 mm Hg or a MAP >65 mm Hg for at least 4 h) was 1 hour (IQR: 5; n = 11).ConclusionsThere was no association between DxSP therapy and survival, duration of vasopressor therapy, or time between steroid administration and discontinuation of vasopressor therapy in dogs being treated for sepsis, vasopressor resistance, and suspected CIRCI.