bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the effects of computerized versus manual methods of identifying point-specific acupuncture as an adjunct to physiotherapy in the management of knee osteoarthritis: A randomized controlled trial protocol
Authors: Li Lee Chai , Ahmad Mohd Azzuan , Hou Tan Chee , Ann Je Angeline Low , Lin Lee Zi , Ling Tay Yan , Yan Peng 
Published: January 2025

Background
Knee osteoarthritis (KOA) is a prevalent condition causing significant pain and functional impairment. Acupuncture has shown promise as an adjunctive therapy, but conventional manual selection of acupoints lacks standardization. The Acugraph system provides a computerized method for identifying acupoints, potentially enhancing treatment precision.

Objective
This study aims to compare the effects of computerized Acugraph-guided acupuncture versus manually selected acupuncture as adjuncts to physiotherapy in managing KOA.

Methods
A randomized, double-blind controlled trial will be conducted with 50 participants diagnosed with mild to moderate KOA. Participants will be randomly assigned to one of two groups: Group 1 Comp-AcuPhysio (n = 25), receiving Acugraph-guided acupuncture with physiotherapy, or Group 2 Man-AcuPhysio (n = 25), receiving manually selected acupuncture with physiotherapy. Both groups will undergo 12 weekly treatment sessions, each lasting 60 minutes. Outcome measures, including the Knee Injury and Osteoarthritis Outcome Score, active knee flexion range, Timed Up and Go test, Visual Analog Scale for pain, Short Form-36 health survey, and Personal Integrated Energetics score, will be assessed at baseline and immediately post-intervention. An intention-to-treat analysis will be applied. Changes from baseline to 12 weeks will be analyzed using repeated measures analysis of variance for both within-group and between-group comparisons.

Results
This study will provide a definitive assessment of the effectiveness of computerized Acugraph-guided acupuncture compared to manually selected acupuncture as supplementary treatments alongside KOA physiotherapeutic rehabilitation.

Conclusion
This trial will offer insights into how incorporating technology-driven approaches, such as Acugraph, with physiotherapy can enhance the customization and effectiveness of KOA management, leading to improved clinical outcomes. These results could advocate for the integration of technological tools in acupuncture to boost treatment precision and efficacy for KOA.

Trial registration
Australian New Zealand Clinical Trials Registry (ACTRN12624000646549p).
Comparing the technical and individual possession statistics of academy players across different age groups in match-play
Authors: Escreet Emily , Barrett Steve , Toner John , Iga John , Towlson Christopher 
Published: January 2025

Background
Youth soccer players in the UK transition into the professional game at 16 years of age. Understanding the differences between youth and professional standards can help coaches and clubs to support player development during this transition.

Objectives
To (i) assess the differences in technical and possession statistics between different age groups (U16, U18, U23) and outfield positions (central defender [CD], wide defender [WD], central midfielder [CM], attacking midfielder [AM], wide midfielder [WM], striker [ST]), within an English academy soccer programme, during match-play.

Methods
All matches were monitored using foot-mounted inertial measurements units (F-IMU; Playermaker™) to quantify the technical (touches and releases from the feet) and individual possession statistics (Time on the ball, Time on the ball per possession) from each match. Teams were instructed to play a 1-4-3-3 formation as part of their clubs playing philosophy, with positions defined per this formation. Data were analysed using a multi-variate ANOVA Two-tailed statistical significance was accepted as p ≤ 0.05 and measures of effect size were calculated using partial eta-squared (η2). Magnitude of the effect sizes were small (0.2<ES<0.6), moderate (0.6<ES<1.2), large (1.2<ES<2) and very large (≥2).

Results
Trivial to small effect sizes were observed across age groups for both technical and possession-based statistics during match-play. Across all age groups and positions, CD`s had the highest number of technical actions (touches and releases), whereas ST`s & AM`s, had the highest amount of time in possession of the ball. Further, positional analysis showed ST`s and AM`s had moderate to large decreases in time on the ball per possession at the U23’s age group in comparison to the U16 and U18’s, with no technical differences observed within the same positional analysis.

Conclusion
Attacking players (AM & ST) are required to move the ball quicker as they progress from U16 to U23’s within the current English football academy. Further exploration is required to assess if these changes are context specific given requirements of those age groups.
Forecasting the use of chiropractic services within the Veterans Health Administration
Authors: Bensel Victoria A. , Corcoran Kelsey , Lisi Anthony J. 
Published: January 2025

Objective
To model future use of chiropractic services and predict clinical resource needs within the Veterans Health Administration (VA) over the next 5 years.

Methods
A serial cross-sectional analysis of chiropractic use data from VA’s Corporate Data Warehouse for fiscal years (FY) 2017 through 2022 (10/1/2016-9/30/2022). We calculated the proportion of VA chiropractic users–via care provided on-station and/or purchased from Community Care Network (CCN) providers–compared to overall VA healthcare users for each FY. We calculated the historical year-over-year compound annual growth rate (CAGR), which was used to predict use in FY2023 through 2027 (10/1/2022-9/30/2027).

Results
VA’s chiropractic use rate increased from 1.4% in FY2017 to 3.5% in FY2022, at which point 2.0% of VA users received only CCN chiropractic care, 1.3% only on-station, and 0.2% both. During the 6-year observation period, the CAGRs were overall 17.9%, CCN only 23.8%, on-station only 12.4%, and both 27.7%. Using those rates to extrapolate, by the end of FY2027 overall use will be 8.9%, with 5.9% only CCN, 2.3% only on-station, and 0.6% both.

Conclusion
Overall use of VA chiropractic services is projected to more than double from FY 2022 to FY2027. These findings underscore the need for proactive resource planning to address the expected increased use of both CCN and on-station care.
Development and validation of the Health Segment Classification of Population Encompassed within Singapore (HealthSCOPES) framework
Authors: Ang Ian Yi Han , Rahman Nabilah , Wong Shing Hei , Ng Sheryl Hui-Xian , Tan Kyle Xin Quan , Eh Ke Xin , Ling Zheng Jye , Lim Andrea Su En , Tan Kelvin Bryan , Toh Sue Anne 
Published: January 2025

Introduction
The population is heterogeneous with varying levels of healthcare needs. Clustering individuals into health segments with more homogeneous healthcare needs allows for better understanding and monitoring of health profiles in the population, which can support data-driven resource allocation.

Methods
Using the developed criteria, data from several of Singapore’s national administrative datasets were used to classify individuals into the various health segments. Cross-sectional analysis of healthcare utilization charges was conducted. Validation was done for the framework’s prognostic ability of clinically relevant outcomes measured in the following year.

Results
The framework is comprised of twelve segments classed within four broad groups. The segments comprising individuals with cancer, with transitional care needs, and in the last year of their lives had the highest mean per resident healthcare charges. The segments comprising adults and seniors with complex chronic conditions and with transitional care needs had the highest percentage of individuals historically diagnosed with obesity. The framework was able to distinguish varying tiers of healthcare utilization charges and relative risk of death in the following year.

Discussion
The framework was developed using a hybrid approach, with expert input and comprehensive national data that extended beyond the usual hospital patient population. The framework can be directly applied for use in program or policy design, evaluation, and cost-effectiveness analyses.

Conclusion
The HealthSCOPES framework was developed to segment the entire population in Singapore with similar healthcare needs.
Capacity-building interventions for health extension workers in Ethiopia: A scoping review
Authors: Astale Tigist , Mesele Helina , Pasquino Sarah-Louise , Zewdie Anteneh , Wolka Eskinder , Endalamaw Aklilu , Assefa Yibeltal , Mitike Getnet 
Published: January 2025

Introduction
Capacity-building interventions for health extension workers (HEWs) are key to providing quality health services to the community. Since Ethiopia’s Health Extension Program was established, several types of capacity-building interventions have been developed to build HEW competencies. However, no comprehensive study has mapped the types of capacity-building interventions being used or the competencies targeted.

Objective
To (1) identify and characterize evidence on capacity-building interventions for Ethiopian HEWs, including the competencies measured; (2) clarify evidence gaps in this area; and (3) explore how successful the interventions have been to inform the design of health extension programs and further research.

Methods
We used keywords (health extension workers, capacity building, competencies) and related terminologies to search PubMed, Scopus, and Embase for published studies on capacity-building interventions for Ethiopian HEWs, and Google Scholar for unpublished studies and reports. Our search was limited to studies and reports published in English from 2003 to present. We used the JBI scoping review methodology to conduct this scoping review in a stepwise approach and a categorization approach to synthesize the evidence.

Results
Our search strategy identified 20 articles, all published except for one program report. The most common capacity-building intervention designed for HEWs was training, followed by supportive supervision, performance review and clinical mentoring meetings, and equipment supply; the most salient competency domains investigated were knowledge and skills. The interventions significantly improved immediate outcomes (knowledge, skills, attitude change among HEWs) and intermediate outcomes, such as increased service utilization and health-seeking behavior among community members. Only one study assessed whether capacity-building interventions improved inter- and intra-personal domains of capacity/competency.

Conclusions
Capacity-building interventions for Ethiopian HEWs were found to be effective, but they mainly focused on improving technical competencies, such as knowledge and skills. Little attention has been paid to other competency domains, including motivation, leadership, and communication. Thus, future research could focus on a comprehensive set of capacity-building initiatives that addresses motivation, job satisfaction, communication, commitment, and resource allocation.
Paediatric sedation with intranasal dexmedetomidine: Protocol for a systematic review and meta-analysis
Authors: Nissen Katrine Dueholm , Moos Caroline Margaret , Wolf Andras , Strøm Thomas 
Published: January 2025

Introduction
Sedation ensures a child remains motionless during a procedure and decreases anxiety. Several pharmacologic regimes exist for paediatric sedation. However, often, intravenous cannulation is required, causing distress for the child. Creating a low-stress environment for children during medical procedures is crucial. Intranasal dexmedetomidine offers a promising alternative by either removing the need for intravenous cannulation or significantly reducing stress and anxiety when cannulation is necessary. We aim to investigate the safety and efficiency of sedating children with intranasal dexmedetomidine.

Methods and analysis
We will systematically search MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCO), CENTRAL, Clinicaltrials.gov, and the WHO ICTRP portal. We will include all randomized controlled trials (RCT) that investigate the use of intranasal dexmedetomidine compared to alternative sedatives for premedication or sedation of children. Two researchers will independently screen title/abstract and full-text articles for eligibility using Covidence. Our primary outcome is sedation success rate. RCTs that meet the inclusion criteria will form the unit of analysis. Data extracted from each study will be presented in table format (S2 Table). Information on parameters that describe safety and efficiency outcomes will be extracted and analysed. Outcome data will be reported as risk ratios and 95% confidence intervals (CI) for dichotomous outcomes or mean and standardized mean differences with 95% CI for continuous outcomes. The assessment of statistical heterogeneity will be examined using Chi2- and I2-statistics. PROSPERO registration number CRD42024532993

Discussion
Sedation with intranasal dexmedetomidine is not common practice in all countries, though the medicament has the potential to provide a child-friendly approach to sedation and premedication. Reviews on the area are conflicting, and new RCT studies have been published. Our systematic review aims to comprehensively assess intranasal paediatric sedation, focusing on dexmedetomidine and guiding clinicians in daily decision-making for optimal paediatric sedation.
Unexpected effects of pandemic-related changes on mental health: Evidence from a nationwide survey in South Korea
Authors: Kim Won-Hyoung , Kim Jonghun , Oh Jiyun , Lee Seolim , Chang Jihwan , Kim Younhee 
Published: January 2025

Background
Substantial evidence indicates that the COVID-19 pandemic has adversely affected population mental health globally. However, most studies assumed a linear relationship where only negative pandemic-induced changes led to worse mental health outcomes, overlooking the complex relationship between COVID-19-related changes and mental health. This study examined how various types and magnitudes of pandemic-related changes relate to depression and suicidal thoughts in a large, nationwide adult population sample.

Methods
We analyzed data from the 2021 Korean Community Health Survey, a cross-sectional survey of 229,213 adults. The study examined the association between mental health outcomes and three types of pandemic-related changes: daily life impact (scored 0–100), economic activities (employment and income changes), and health behaviors (physical activity, instant food consumption, alcohol consumption, and smoking). Complex sample multiple logistic regression analysis was used to assess these associations, adjusting for sociodemographic factors.

Results
The relationship between pandemic-related changes and mental health showed non-linear patterns. Compared to those reporting moderate changes, individuals reporting either no change (depression: aOR 1.253, 95% CI 1.135–1.384; suicidal thoughts: aOR 1.355, 95% CI 1.236–1.486) or complete disruption (depression: aOR 1.895, 95% CI 1.667–2.155; suicidal thoughts: aOR 1.788, 95% CI 1.558–2.052) in daily life showed higher risks of poor mental health. Unexpectedly, positive changes such as improved working conditions (suicidal thoughts: aOR 1.419, 95% CI 1.200–1.677) and increased income (depression: aOR 1.304, 95% CI 1.139–1.493; suicidal thoughts: aOR 1.244, 95% CI 1.079–1.435) were also associated with adverse mental health outcomes.

Conclusions
This study reveals that both minimal and substantial changes in daily life, as well as both positive and negative changes in economic conditions and health behaviors, were associated with poor mental health outcomes during the pandemic. These findings suggest the need for comprehensive mental health interventions that consider various types and magnitudes of life changes during crisis situations.
Associations of RANKL levels and polymorphisms with rheumatoid arthritis: A meta-analysis
Authors: Lee Young Ho , Song Gwan Gyu 
Published: January 2025

Objectives
This study examined the correlation between circulating receptor activator for nuclear factor-κB ligand (RANKL) levels and rheumatoid arthritis (RA), and investigated the association between polymorphisms in the RANKL gene and susceptibility to RA.

Method
We searched the Medline, Embase, and Cochrane databases for relevant publications up to September 2024. A meta-analysis was conducted to assess serum/plasma RANKL levels in patients with RA and controls, and to explore the relationship between RANKL rs9533156 and rs2277438 polymorphisms and RA susceptibility.

Results
Ten studies encompassing 1,682 RA patients and 1,288 controls were analyzed. RANKL levels were significantly higher in RA patients compared to controls (SMD = 0.665, 95% CI = 0.290–1.040, P = 0.001). Subgroup analysis affirmed these findings’ consistency across different sample sizes and publication years. RANKL levels were positively associated with rheumatoid factor (RF) and Disease Activity Score-28 (DAS28) (RF correlation coefficient = 0.157, 95% CI = 0.028–0.282, P = 0.018; DAS28 correlation coefficient = 0.151, 95% CI = 0.125–0.370, P < 0.001). Additionally, the meta-analysis revealed significant associations between the susceptibility to RA and the RANKL rs9533156 C allele (OR = 0.609, 95% CI = 0.520–0.714, P < 0.010) as well as the rs2277438 G allele (OR = 1.206, 95% CI = 1.003–1.451, P = 0.047). These associations were consistent across homozygote comparisons and different genetic models.

Conclusions
This meta-analysis underscores the elevated circulating RANKL levels in RA patients and their significant correlation with RF and DAS28. Additionally, the RANKL rs9533156 and rs2277438 polymorphisms were significantly associated with RA susceptibility.
We have the technology
Authors: Larsen Kristian 
Published: January 2025

This discussion reflects on obsolescence as a hauntology through the lens of an interdisciplinary, critical-creative, artistic practice of improvisation. The practice is grounded in contemporary dance, choreographic thinking, experimental sound and is distracted by relationships between the body and technology. The writing offers further exposition, speculating on and generating insights about improvisation in relation to dance and technologically mediated sound in live performance. Informed by cultural theorist Mark Fisher’s perspectives (2012) and French philosopher Jacques Derrida’s notion of hauntology (1994), this article reflects on relationships between hyper-capitalism and obsolescence. Those relationships are considered a terroir of affect acting constantly upon both practice and practitioner. Notions of improvision (not to be confused with the word ‘improvisation’ in this writing) are explored in relation to hyper-capitalism and obsolescence, revealing challenges around ageing, futurity and artistic production. Improvisation is itself proposed as a meta-resource for responding to issues that can emerge through improvising a dance–sound art form.
From these reflections, a critical framework is developed, which at times threatens to overshadow the practice. Within that critical framework, a process of renovation emerges along with novel perspectives and discoveries about pre-existing materials, skills, practitioner knowledge and hope.
Does mental exertion during incremental exercise change substrate oxidation and cardiorespiratory outcomes in individuals with overweight?
Authors: Pourmirzaei Kouhbanani Samira , Setarehdan Seyed Kamaledin , Fayazmilani Rana 
Published: January 2025

AbstractGiven the growing concern over the impact of brain health in individuals with overweight, understanding how mental exertion (ME) during exercise affects substrate oxidation and cardiorespiratory outcomes is crucial. This study examines how ME impacts these outcomes during an incremental exercise test in adults with overweight. Seventeen adults who were overweight completed an incremental exercise test on a cycle ergometer two times, with and without the Stroop task. Energy expenditure (EE), carbohydrate and fat oxidation, maximum heart rate (HRmax), maximal oxygen uptake (VO2max), maximum fat oxidation (MFO), and the intensity of exercise that elicited MFO (Fatmax) are measured by indirect calorimetry. ME did not change the EE, carbohydrate, and fat oxidation at any stages of the incremental test. However, ME resulted in significantly lower HRmax, VO2max, and MFO (p < 0.01) and increased NASA‐TLX scores but showed no change in Fatmax. These results show ME decreases the value of HRmax, VO2max, and MFO during the incremental exercise test. Due to the increased mental workload demonstrated by the NASA‐TLX test, adults with overweight are unable to complete the test to the same extent as they did in the test without ME according to maximal levels in this study.
Stability on 3D Boussinesq system with mixed partial dissipation
Authors: Lin Hongxia , Liu Sen , Guo Xiaochuan , You Ruiqi 
Published: January 2025

Abstract
In the article, we are concerned with the three-dimensional anisotropic Boussinesq equations with the velocity dissipation in

x

2

{x}_{2}

and

x

3

{x}_{3}

directions and the thermal diffusion in only

x

3

{x}_{3}

direction. When the spatial domain is the whole space

R

3

{{\mathbb{R}}}^{3}

, the global well-posedness and stability problem for the partially dissipated Boussinesq system remain the extremely challenging open problems. Attention here focuses on the periodic domain

Ω
=
R
×

T

2

\Omega ={\mathbb{R}}\times {{\mathbb{T}}}^{2}

. We aim at establishing the stability for the problem of perturbations near hydrostatic equilibrium and the large-time behavior of the perturbed solution. We first obtain the global existence of some symmetric fluids in

H

2

(

Ω

)

{H}^{2}\left(\Omega )

for small initial data. Then the exponential decay rates for the oscillations

u

˜

\widetilde{u}

and

θ

\theta

in

H

1

(

Ω

)

{H}^{1}\left(\Omega )

and the homogeneous Sobolev space

H

v

2

˙

(

Ω

)

\dot{{H}_{v}^{2}}\left(\Omega )

are also shown. The proof is based on a key observation that we can decompose the velocity

u

u

into the average

u

¯

\overline{u}

on

T

2

{{\mathbb{T}}}^{2}

and the corresponding oscillation

u

˜

\widetilde{u}

. This enables us to establish the strong Poincaré-type inequalities on

u

˜

\widetilde{u}

,

u

3

,
θ

{u}_{3},\theta

and some anisotropic inequalities, which ensure the establishment of the closed priori estimates. In addition, we also prove the oscillations in one direction

u

˜

(

2

)

,

u

˜

(

3

)

{\widetilde{u}}^{\left(2)},{\widetilde{u}}^{\left(3)}

in

H

1

(

Ω

)

{H}^{1}\left(\Omega )

decay to zero exponentially.