bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-economic evaluation of meniscus tear treatments: a systematic review
Authors: Deviandri R. , Daulay M. C. , Iskandar D. , Kautsar A. P. , Lubis A. M. T. , Postma M. J. 
Published: January 2023

Abstract
Purpose
To evaluate the overall evidence of published health-economic evaluation studies on meniscus tear treatment.

Methods
Our systematic review focuses on health-economic evaluation studies of meniscus tear treatment interventions found in PubMed and Embase databases. A qualitative, descriptive approach was used to analyze the studies’ results and systematically report them following PRISMA guidelines. The health-economic evaluation method for each included study was categorized following one of the four approaches: partial economic evaluation (PEE), cost-effectiveness analysis (CEA), cost–benefit analysis (CBA), or cost-utility analysis (CUA). The quality of each included study was assessed using the Consensus on Health Economic Criteria (CHEC) list. Comparisons of input variables and outcomes were made, if applicable.

Results
Sixteen studies were included; of these, six studies performed PEE, seven studies CUA, two studies CEA, and one study combined CBA, CUA, and CEA. The following economic comparisons were analyzed and showed the respective comparative outcomes: (1) meniscus repair was more cost-effective than arthroscopic partial meniscectomy (meniscectomy) for reparable meniscus tear; (2) non-operative treatment or physical therapy was less costly than meniscectomy for degenerative meniscus tear; (3) physical therapy with delayed meniscectomy was more cost-effective than early meniscectomy for meniscus tear with knee osteoarthritis; (4) meniscectomy without physical therapy was less costly than meniscectomy with physical therapy; (5) meniscectomy was more cost-effective than either meniscus allograft transplantation or meniscus scaffold procedure; (6) the conventional arthroscopic instrument cost was lower than laser-assisted arthroscopy in meniscectomy procedures.

Conclusion
Results from this review suggest that meniscus repair is the most cost-effective intervention for reparable meniscus tears. Physical therapy followed by delayed meniscectomy is the most cost-effective intervention for degenerative meniscus tears. Meniscus scaffold should be avoided, especially when implemented on a large scale.

Level of evidence
Systematic review of level IV studies.
Doxorubicin-induced acute cardiotoxicity is associated with increased oxidative stress, autophagy, and inflammation in a murine model
Authors: Dulf Patricia Lorena , Mocan Mihaela , Coadă Camelia Alexandra , Dulf Daniel Vasile , Moldovan Remus , Baldea Ioana , Farcas Anca-Daniela , Blendea Dan , Filip Adriana Gabriela 
Published: January 2023

Abstract
Drug-induced cardiotoxicity is a life-threatening side effect of doxorubicin (DOX) treatment that impacts patient prognosis and survival. In the majority of cases, the acute clinical form often remains asymptomatic, with few patients presenting rather nonspecific electrocardiographic abnormalities. While chronic toxicity has been more widely studied, the alterations appearing in acute cardiotoxicity are much less investigated. Thus, our in vivo study aimed to evaluate the process of DOX-induced acute myocardial toxicity by investigating oxidative stress and autophagy markers as mechanisms of myocardial toxicity in correlation with echocardiography and electrocardiography findings. Our results show that both autophagy and oxidative homeostasis were disrupted as soon as 7 days after DOX treatment, alterations that occurred even before the significant increase of NT-proBNP, a clinical marker for cardiac suffering. Moreover, we found a large number of alterations in the electrocardiography and echocardiography of treated rats. These findings suggest that DOX-induced myocardial toxicity started early after treatment initiation, possibly marking the initial phase of the unfolding process of cardiac damage. Further studies are required to completely decipher the mechanisms of DOX-induced cardiotoxicity.
Graphical Abstract
Evaluating the “wrong-way-round” electrospray ionization of antiretroviral drugs for improved detection sensitivity
Authors: Venter Pieter , van Onselen Rianita 
Published: January 2023

AbstractThe presence of antiretroviral drugs (ARVDs) in the aquatic environment poses a significant health risk to the ecosystem. The dilution of these compounds during wastewater treatment processes, followed by discharge into the environment, results in extremely low concentrations in the range of ng/L. Therefore, to enable detection of these low concentrations, it is important to determine the most efficient electrospray ionization (ESI) mode using the right mobile phase modifier and to establish a selective extraction procedure. In this study, we compared the ESI intensity in the positive and negative mode using both formic acid (FA) and ammonium hydroxide (NH4OH) as mobile phase modifiers. The results revealed a phenomenon known as the “wrong-way-round” (WWR) ESI in which high intensity [M + H]+ ions were detected under basic conditions using NH4OH as modifier and, similarly, high intensity [M-H]− ions were detected under acidic conditions using FA as modifier. Furthermore, mixed-mode strong cation (MCX) and mixed-mode strong anion (MAX) exchange sorbents were evaluated for extraction recoveries, which yielded extraction recoveries between 60 and 100%. Finally, the recoveries obtained using mixed-mode ion exchange sorbents compared to ion production during the ESI process provide evidence that ions produced in solution do not necessarily reflect the ions that are produced during the ESI process. Based on the results of this study, it is recommended to evaluate the optimal ionization mode under basic and acidic conditions, instead of defaulting to the use of acidic modifiers with positive ion detection.
Threat Perception and Adaptive Capacity of Natural World Heritage Site Management
Authors: Falk Martin Thomas , Hagsten Eva 
Published: January 2023

AbstractThis study offers new insights into the largest threats to natural and mixed World Heritage sites in developed countries as considered by their management. In addition to this, the capacity of the management to deal with threats is examined. An Ordered Probit model is used that distinguishes three groups of threats and four categories of adaptive capacity of the management. Data originate from the 2014 UNESCO Periodic Report II for sites in economically advanced countries (Europe, North America, Australia, New Zealand, Japan and South Korea) linked to the World Heritage Site database. Estimation results reveal that the probability of a major threat to World Heritage sites is perceived to be highest in the category of climate change and extreme weather events, followed by local conditions affecting the physical structure (temperature, rain, dust). Sites in tropical climates are perceived as significantly more threatened, as are those earlier listed as in danger. The likelihood of perceiving a major threat is highest in Turkey, Italy, Norway and North America. Threats related to climate change are those the management has the lowest capacity to deal with when other important aspects are controlled for. Large and natural areas have a higher perceived administrative capacity to deal with threats than others.
Herpes zoster in patients with inflammatory arthritides or ulcerative colitis treated with tofacitinib, baricitinib or upadacitinib: a systematic review of clinical trials and real-world studies
Authors: Gialouri Chrysoula G. , Moustafa Savvina , Thomas Konstantinos , Hadziyannis Emilia , Vassilopoulos Dimitrios 
Published: January 2023

AbstractJAK inhibitors (JAKi) are new targeted-synthetic drugs, approved for various immune-mediated inflammatory diseases (IMIDs), including inflammatory arthritides (rheumatoid arthritis—RA, psoriatic arthritis—PsA, ankylosing spondylitis—AS) and ulcerative colitis (UC). JAKi have been associated with increased risk for herpes zoster (HZ), but the relative risk among different JAKi in these IMIDs remains unclear. We aimed to systematically review the incidence of HZ among RA, PsA, AS and UC patients treated with the approved doses of tofacitinib (TOFA), baricitinib (BARI) or upadacitinib (UPA). PubMed, Embase, Scopus, Cochrane and Web-of-Science were searched up to 30 March 2022. Clinical trials and real-world studies (RWS) were included. Outcomes assessed were the incidence rate (/100 patient-years) or/and cumulative incidence of HZ. From 1710 records, 53 clinical trials and 25 RWS were included (RA: 54, PsA: 8, AS: 4, and UC: 12). In clinical trials, the HZ-incidence was higher in TOFA-treated patients with RA (2.2–7.1/100 patient-years) or UC (1.3–7.6/100 patient-years) compared to PsA (1.7/100 patient-years), and with higher doses of TOFA in UC (10 mg/twice daily: 3.2–7.6/100 patient-years vs. 5 mg/twice daily: 1.3–2.3/100 patient-years). Evidence for HZ-risk in JAKi-treated patients with AS and in UPA-treated patients was limited. The HZ-incidence between TOFA and BARI groups in 2 RA RWS did not differ significantly. Concomitant glucocorticoid, but not methotrexate, use in RA increased the HZ-risk. This systematic review showed higher HZ-risk in RA or UC than PsA patients treated with TOFA, in those treated with higher TOFA doses or with concomitant glucocorticoids. Preventive measures and monitoring of JAKi-treated patients with IMIDs are essential in daily practice.
Dynamic Transcriptome Changes Driven by the Mutation of OsCOP1 Underlie Flavonoid Biosynthesis and Embryogenesis in the Developing Rice Seed
Authors: Kim Backki , Shim Sangrea , Zhang Hongjia , Lee Chunseok , Jang Su , Jin Zhuo , Seo Jeonghwan , Kwon Soon-Wook , Koh Hee-Jong 
Published: January 2023

AbstractCONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), an E3 ubiquitin ligase, functions as a central repressor of light signaling and regulates various light-mediated developmental and metabolic processes in plants. However, detailed mechanisms underlying COP1-regulated flavonoid biosynthesis and embryogenesis in rice seeds remain largely unknown. Here, we performed transcriptome analysis of the rice cop1 (yellowish-pericarp embryo lethal [yel]) null mutant, characterized by flavonoid accumulation in pericarp and abnormal development of embryo, to identify and profile the expression genes involved in flavonoid biosynthesis and embryo development. Comparative transcriptome analysis of yel-hc and wild-type seeds revealed 979 differentially expressed genes (DEGs), of which 577 were upregulated and 402 were downregulated in yel-hc seeds. Functional annotation of DEGs revealed that DEGs were mainly enriched in ‘metabolism’, ‘transcription factors’, ‘secondary metabolites’, and ‘flavonoid biosynthesis’. The DEGs encoding AP2-EREBP, MYB, and bZIP transcription factors (TFs) were predominantly upregulated, whereas those encoding HB, bHLH, and ABI3VP1 TFs were downregulated in yel-hc seeds. Comparative gene expression analysis revealed that genes involved in the C-glycosyl flavone biosynthesis pathway, including OsP1, were activated, whereas anthocyanin biosynthesis genes showed no significant change in expression. In addition, transcript levels of embryo development-related genes, especially homeobox auxin regulation genes, as well as somatic embryogenesis-related genes, were significantly downregulated in yel-hc. Taken together, these results indicate that OsCOP1 plays a crucial role in regulation of flavonoid biosynthesis and embryo structure formation, and changes in the expression of light signal transduction-related genes could have a significant impact on flavonoid biosynthesis and embryogenesis in rice seed.
Long-term functional outcome after tubular laparoscopic sigmoid resection for diverticular disease
Authors: Abdalla Thaer S. A. , Zimmermann Markus , Weisheit Lena , Thomaschewski Michael , Deichmann Steffen , Nolde Jan , Keck Tobias , Benecke Claudia 
Published: January 2023

Abstract
Purpose
Sigmoid resection for diverticular disease is a frequent surgical procedure in the Western world. However, long-term bowel function after sigmoid resection has been poorly described in the literature. This study aims to assess the long-term bowel function after tubular sigmoid resection with preservation of inferior mesenteric artery (IMA) for diverticular disease.

Methods
We retrospectively identified patients who underwent sigmoid resection for diverticular disease between 2002 and 2012 at a tertiary referral center in northern Germany. Using well-validated questionnaires, bowel function was assessed for fecal urgency, incontinence, and obstructed defecation. The presence of bowel dysfunction was compared to baseline characteristics and perioperative outcome.

Results
Two hundred and thirty-eight patients with a mean age of 59.2 ± 10 years responded to our survey. The follow-up was conducted 117 ± 32 months after surgery. At follow-up, 44 patients (18.5%) had minor LARS (LARS 21–29) and 35 (15.1%) major LARS (LARS ≥ 30–42), 35 patients had moderate-severe incontinence (CCIS ≥ 7), and 2 patients (1%) had overt obstipation (CCOS ≥ 15). The multivariate analysis showed that female gender was the only prognostic factor for long-term incontinence (CCIS ≥ 7), and ASA score was the only preoperative prognostic factor for the presence of major LARS at follow-up.

Conclusion
Sigmoid resection for diverticular disease can be associated with long-term bowel dysfunction, even with tubular dissection and preservation of IMA. These findings suggest intercolonic mechanisms of developing symptoms of bowel dysfunction after disruption of the colorectal continuity that are so far summarized as “sigmoidectomy syndrome.”
Effectiveness of radiation protection systems in the cardiac catheterization laboratory: a comparative study
Authors: Cammann Victoria L. , Schweiger Victor , Cieslik Maciej , Seifert Burkhardt , Gilhofer Thomas , Koleva Iva , Würdinger Michael , Candreva Alessandro , Gajic Marko , Michel Jonathan , Jakob Philipp , Stehli Julia , Stähli Barbara , Templin Christian , Gotschy Alexander 
Published: January 2023

Abstract
Background
As numbers and complexity of percutaneous coronary interventions are constantly increasing, optimal radiation protection is required to ensure operator safety. Suspended radiation protection systems (SRPS) and protective scatter-radiation absorbing drapes (PAD) are novel methods to mitigate fluoroscopic scattered radiation exposure. The aim of the study was to investigate the effectiveness regarding radiation protection of a SRPS and a PAD in comparison with conventional protection.

Methods
A total of 229 cardiac catheterization procedures with SRPS (N = 73), PAD (N = 82) and standard radiation protection (N = 74) were prospectively included. Real-time dosimeter data were collected from the first operator and the assistant. Endpoints were the cumulative operator exposure relative to the dose area product [standardized operator exposure (SOE)] for the first operator and the assistant.

Results
For the first operator, the SRPS and the PAD significantly decreased the overall SOE compared to conventional shielding by 93.9% and 66.4%, respectively (P < 0.001). The protective effect of the SRPS was significantly higher compared to the PAD (P < 0.001). For the assistant, the SRPS and the PAD provided a not statistically significant reduction compared to conventional shielding in the overall SOE by 38.0% and 30.6%, respectively.

Conclusions
The SRPS and the PAD enhance radiation protection significantly compared to conventional protection. In most clinical scenarios, the protective effect of SRPS is significantly higher than the additional protection provided by the PAD.

Graphical abstract
Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction
Authors: Konijnenberg Lara S. F. , Luiken Tom T. J. , Veltien Andor , Uthman Laween , Kuster Carolien T. A. , Rodwell Laura , de Waard Guus A. , Kea-te Lindert Mariska , Akiva Anat , Thijssen Dick H. J. , Nijveldt Robin , van Royen Niels 
Published: January 2023

AbstractFollowing an acute myocardial infarction, reperfusion of an occluded coronary artery is often accompanied by microvascular injury, leading to worse long-term prognosis. Experimental studies have revealed the potential of tyrosine-kinase inhibitor imatinib to reduce vascular leakage in various organs. Here, we examined the potential of imatinib to attenuate microvascular injury in a rat model of myocardial reperfusion injury. Isolated male Wistar rat hearts (n = 20) in a Langendorff system and male Wistar rats (n = 37) in an in vivo model were randomly assigned to imatinib or placebo and subjected to ischaemia and reperfusion. Evans-blue/Thioflavin-S/TTC staining and Cardiac Magnetic Resonance Imaging were performed to assess the extent of reperfusion injury. Subsequently, in vivo hearts were perfused ex vivo with a vascular leakage tracer and fluorescence and electron microscopy were performed. In isolated rat hearts, imatinib reduced global infarct size, improved end-diastolic pressure, and improved rate pressure product recovery compared to placebo. In vivo, imatinib reduced no-reflow and infarct size with no difference between imatinib and placebo for global cardiac function. In addition, imatinib showed lower vascular resistance, higher coronary flow, and less microvascular leakage in the affected myocardium. At the ultrastructural level, imatinib showed higher preserved microvascular integrity compared to placebo. We provide evidence that low-dose imatinib can reduce microvascular injury and accompanying myocardial infarct size in a rat model of acute myocardial infarction. These data warrant future work to examine the potential of imatinib to reduce reperfusion injury in patients with acute myocardial infarction.
Smokers have increased risk of soft-tissue complications following primary elective TKA
Authors: Starzer Moritz , Smolle Maria Anna , Vielgut Ines , Hauer Georg , Leitner Lukas , Radl Roman , Ehall Reinhard , Leithner Andreas , Sadoghi Patrick 
Published: January 2023

Abstract
Introduction
Smoking has been associated with numerous adverse outcomes following surgical procedures. The purpose of this study was to investigate, whether smoking status at time of surgery influences the outcome of primary TKA.

Materials and methods
Six hundred and eighty-one patients who underwent primary TKA between 2003 and 2006 were included in the study. Smoking status was defined as current, former, and never smoker. Complications leading to revisions were assessed until 17 years of follow-up. Functional outcome was evaluated using clinical scores: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS) for pain, Short Form-12 Physical and Mental Component Summaries (SF-12PCS/MCS), and Knee Society Function and Knee Score (KSFS and KSKS).

Results
At a mean follow-up of 95 months (± 47 months), 124 complications led to revision surgery. Soft-tissue complications (OR, 2.35 [95% CI 1.08–5.11]; p = 0.032), hematoma formation (OR, 5.37 [95% CI 1.01–28.49]; p = 0.048), and restricted movement (OR, 3.51 [95% CI 1.25–9.84]; p = 0.017) were more likely to occur in current smokers than never smokers. Current smokers were more likely to score higher at KSFS (p < 0.001) and SF-12PCS (p = 0.0197) compared to never smokers. For overall revision, differences were noted.

Conclusion
Current smoking increases risk of soft-tissue complications and revision after primary TKA, especially due to hematoma and restricted movement. Smoking cessation programs could reduce the risk of revision surgery.
Heat acclimation reduces the effects of whole-body hyperthermia on knee-extensor relaxation rate, but does not affect voluntary torque production
Authors: Gordon Ralph Joseph Frederick Hills , Moss Jodie Natasha , Castelli Federico , Reeve Thomas , Diss Ceri Elen , Tyler Christopher James , Tillin Neale Anthony 
Published: January 2023

Abstract
Purpose
This study investigated the effects of acute hyperthermia and heat acclimation (HA) on maximal and rapid voluntary torque production, and their neuromuscular determinants.

Methods
Ten participants completed 10 days of isothermic HA (50 °C, 50% rh) and had their knee-extensor neuromuscular function assessed in normothermic and hyperthermic conditions, pre-, after 5 and after 10 days of HA. Electrically evoked twitch and octet (300 Hz) contractions were delivered at rest. Maximum voluntary torque (MVT), surface electromyography (EMG) normalised to maximal M-wave, and voluntary activation (VA) were assessed during brief maximal isometric voluntary contractions. Rate of torque development (RTD) and normalised EMG were measured during rapid voluntary contractions.

Results
Acute hyperthermia reduced neural drive (EMG at MVT and during rapid voluntary contractions; P < 0.05), increased evoked torques (P < 0.05), and shortened contraction and relaxation rates (P < 0.05). HA lowered resting rectal temperature and heart rate after 10 days (P < 0.05), and increased sweating rate after 5 and 10 days (P < 0.05), no differences were observed between 5 and 10 days. The hyperthermia-induced reduction in twitch half-relaxation was attenuated after 5 and 10 days of HA, but there were no other effects on neuromuscular function either in normothermic or hyperthermic conditions.

Conclusion
HA-induced favourable adaptations to the heat after 5 and 10 days of exposure, but there was no measurable benefit on voluntary neuromuscular function in normothermic or hyperthermic conditions. HA did reduce the hyperthermic-induced reduction in twitch half-relaxation time, which may benefit twitch force summation and thus help preserve voluntary torque in hot environmental conditions.
Algorithms and Lower Bounds for Comparator Circuits from Shrinkage
Authors: Cavalar Bruno P. , Lu Zhenjian 
Published: January 2023

AbstractIn this paper, we initiate the study of average-case complexity and circuit analysis algorithms for comparator circuits. Departing from previous approaches, we exploit the technique of shrinkage under random restrictions to obtain a variety of new results for this model. Among them, we show

Average-case Lower Bounds For every $$k = k(n)$$

k
=
k
(
n
)

with $$k \geqslant \log n$$

k
⩾
log
n

, there exists a polynomial-time computable function $$f_k$$

f
k

on n bits such that, for every comparator circuit C with at most $$n^{1.5}/O\!\left( k\cdot \sqrt{\log n}\right) $$

n

1.5

/
O

k
·

log
n

gates, we have $$\begin{aligned} \mathop {{{\,\mathrm{\textbf{Pr}}\,}}}\limits _{x\in \left\{ 0,1\right\} ^n}\left[ C(x)=f_k(x)\right] \leqslant \frac{1}{2} + \frac{1}{2^{\Omega (k)}}. \end{aligned}$$

Pr

x
∈

0
,
1

n

C

(
x
)

=

f
k

(
x
)

⩽

1
2

+

1

2

Ω
(
k
)

.

This average-case lower bound matches the worst-case lower bound of Gál and Robere by letting $$k=O\!\left( \log n\right) $$

k
=
O

log
n

.

$$\#$$
#
SAT Algorithms There is an algorithm that counts the number of satisfying assignments of a given comparator circuit with at most $$n^{1.5}/O\!\left( k\cdot \sqrt{\log n}\right) $$

n

1.5

/
O

k
·

log
n

gates, in time $$2^{n-k}\cdot {{\,\textrm{poly}\,}}(n)$$

2

n
-
k

·

poly

(
n
)

, for any $$k\leqslant n/4$$

k
⩽
n
/
4

. The running time is non-trivial (i.e., $$2^n/n^{\omega (1)}$$

2
n

/

n

ω
(
1
)

) when $$k=\omega (\log n)$$

k
=
ω
(
log
n
)

.

Pseudorandom Generators and $$\textsf {MCSP} $$
MCSP
Lower Bounds There is a pseudorandom generator of seed length $$s^{2/3+o(1)}$$

s

2
/
3
+
o
(
1
)

that fools comparator circuits with s gates. Also, using this PRG, we obtain an $$n^{1.5-o(1)}$$

n

1.5
-
o
(
1
)

lower bound for $$\textsf {MCSP} $$
MCSP
against comparator circuits.