bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 seroprevalence among healthcare workers in Haiti, December 2021
Authors: MICHEL Edwige , Jean-Denis Gladzdin , Denis Hetsner , Bouilly Roberta , Pierre Jean Samuel , Lafontant Donald , Alboth Jocelyne André , Pierre Manise , Dély Patrick , Boncy Jacques , Birmingham Maureen , Marseille Samson 
Published: July 2023

Abstract
Background
Healthcare workers are an exposed group for SARS-CoV-2 and this exposure is a public health priority. Transmission can occur from infected patients to staff and from infected staff to patients and co-workers, thus undermining the health care system. This study estimated the seroprevalence in this population and identified some associated factors.
Methods
We analyzed the exposure of healthcare workers in ten (10) large hospitals providing care to patients with covid-19 by testing for antibodies to SARS-CoV-2. Potential risk factors such as age, vaccination history, barrier measures such as masking were explored through a questionnaire.
Results
From December 06 to 15, 2021, among 3743 health care workers in major hospitals providing care to patients with covid19, a sample of 566 had received serological testing for SARS-COV-2. The mean age was 39 years, 62% were female, and about 12% had hypertension. The vast majority did not reveal any signs and symptoms compatible with COVID19, 62% had already received anti-covid19 vaccine.
The national prevalence regardless of vaccination status was 44%, with a predominance of male gender, age group 60 and older, and the Western Department. Prevalence among unvaccinated persons was 11.59% and never wearing masks was an increased risk of developing antibodies to SARS-COV2.
Conclusion
Among health care workers, covid-19 affects both sexes with a female predominance. The age group over 60 years is the most affected and not wearing a mask is a risk factor associated with virus detection.
Significant decline of an endemic bustard in the Canary Islands
Authors: Ucero Alberto , Alonso Juan C. , Palacín Carlos , Abril-Colón Inmaculada , Álvarez-Martínez José M. 
Published: July 2023

Abstract
The declines of species are caused by a combination of factors that affect survival or breeding success. We studied the effects of a set of environmental and anthropogenic variables on the disappearance of African houbara bustards Chlamydotis undulata fuertaventurae on Fuerteventura (Canary Islands), once the main stronghold of this endangered bird. Of 83 male display sites detected in 1997-1998, only 29 remained occupied in 2020-2021 (65% decrease in only 23 years). We compared habitat quality, density of conspecifics, other steppe birds and crows, presence of human infrastructure, and degree of environmental protection between these 29 extant sites and the 54 extinct sites using univariate analyses and generalised linear models. The most influential variable in the abandonment of display sites was the Normalised Difference Vegetation Index (NDVI), used as an indicator of food resources available to the species, which suggests a strong effect of aridification due to climate change on the species’ extinction process. Power line density was the second most important factor. This suggests that hubaras have survived where higher vegetation productivity has enabled a higher breeding success, and powerline fatalities have caused lower mortality. Higher densities of houbaras, other steppe birds and crows at extant display sites confirmed the better habitat quality in these areas. Extant display sites, located generally in protected areas, had also lower densities of human infrastructure (buildings, roads). We discuss the conservation implications of these results and provide management recommendations for this endangered subspecies.
Assessment of Strength and Microstructural Properties of GGBS based Sustainable Geopolymer Concrete with parametric variations in alkaline solutions
Authors: Prusty Satya Ranjan , Murmu Debadutta , Panigrahi Ramakanta , Jena Sanghamitra 
Published: July 2023

Abstract
Geopolymer binders such as ground granulated blast furnace slag (GGBS) and fly ash (FA) have been promisingly surfaced as probable alternatives to ordinary portland cement (OPC) in concrete preparation over the last few decades. The production of geopolymer concrete (GPC) generates approximately 30–50% less carbon-dioxide (CO2) gas emissions than OPC concrete. GPC not only reduces CO2 emissions, but it also uses industrial solid wastes. To achieve optimum mechanical strength, three parameters which play crucial roles have been considered: Molarity of sodium hydroxide (NH) concentration, solution to binder ratio (S/B) and sodium silicate-sodium hydroxide (NS/NH) proportion. So, in present paper, the mechanical and microstructural characteristics of GPC cured at ambient curing condition using several mixes prepared with varying NaOH concentrations (10M – 16M), solution to binder ratios (Total alkali activator/Total binder content) (0.45 – 0.55) and sodium silicate (NS) to (NH) ratios (1.5 – 2.5) has been investigated. In addition to this, for a conceptualization of environmental impact of GPC, life-cycle assessment (LCA) has been performed.
Neural waves and computation in a neural net model I: Convolutional hierarchies
Authors: Selesnick Stephen Allan 
Published: July 2023

Abstract
The computational resources of a neuromorphic network model introduced earlier are investigated in the context of such hierarchical systems as the mammalian visual cortex. It is argued that a form of ubiquitous spontaneous local convolution, driven by spontaneously arising wave-like activity---which itself promotes local Hebbian modulation---enables logical gate-like neural motifs to form into hierarchical feed-forward structures of the Hubel-Wiesel type. Extra-synaptic effects are shown to play a significant r\^{o}le in these processes. The type of logic that emerges is not Boolean, confirming and extending earlier findings on the logic of schizophrenia.
Anisotropic mechanical response of layered shales: Insights from numerical simulations
Authors: Gao Min , Gong Bin , Liang Zhengzhao , Jia Shanpo , Zou Jiuqun 
Published: July 2023

Abstract
Layered shales exist widely in nature and are often encountered during infrastructure construction. However, the mechanical response of layered shales is significantly affected by the existence of beddings, resulting in the obvious anisotropy characteristics in terms of deformation, strength, and failure mode. To clarify the underlying mechanisms of shale anisotropy that control the safety of engineering projects, the combined numerical simulation and theoretical analysis were conducted. The results show that with the growth of confining pressure, the compressive resistance of shales gradually increases, the shear fractures govern the sample instability, and the anisotropy index continues to decrease. Furthermore, several strength criteria for layered rock masses were summarized, and the modified Jaeger strength criterion was proposed by introducing the anisotropic parameter Rcθ. It can effectively reflect the failure modes and strength features of layered shales under triaxial conditions with the higher accuracy. Besides, the variation of cohesion and internal friction angle of layered shale samples was comprehensively analysed under the triaxial conditions. Clearly, as the inclination angle of bedding planes rises, the cohesion of layered shales first decreases, but then increases under triaxial compression, showing the ‘U’-shaped changing trend. Additionally, the internal friction angle of layered shales grows up gradually with the inclination of bedding planes increasing.
The capacity fading mechanism of high-capacity CrO x （x≥2.5） cathode material for lithium ion battery
Authors: Xu Shan , Lin Ge 
Published: July 2023

Abstract
A series of chromium oxides (CrOx, x ≥ 2.5) as cathode for lithium ion batteries (LIBs) with high capacity were synthesized by a facile method. CV curves and impedance analysis indicated there is some relationship between the structure compositions and electrochemical performance among them. The initial phase transited into two phases in the process of circulation and the higher the ratio of tetrahedrons [CrO4]: octahedrons [CrO6] is, the smaller the potential difference between the two phases. As a case study of Cr8O21 with high ratio of that, ex-situ X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscope show that the phases after transition is the nanoparticles LiCrO2 close to amorphous and the irreversible phase crystal LiCrO2 without providing any capacity, which is the main cause of the drastic capacity fading in the previous circulation. Moreover, Cr8O21 shows a high discharge capacity of 320 mAh g-1 (10 mA g-1) with capacity retention of 88% after 40 cycles. This study provides insight into understanding the mechanism of the capacity fading of a series of chromium oxides and also possibly a means of studying structural evolution in the metal oxides consisted of different valence state.
The improvement of kinsenoside in wild-imitated cultivation Anoectochilus roxburghii associated with endophytic community
Authors: Zheng Ying , Li Lihong , Liu Xinting , Xu Sirui , Sun Xutong , Zhang Zili , Guo Haipeng , Shao Qingsong 
Published: July 2023

Abstract

Background
Kinsenoside, a predominant pharmacologically active component in Anoectochilus roxburghii, exhibits great liver protective effect for treating non-alcoholic steatohepatitis, autoimmune hepatitis, alcoholic liver injury, and liver fibrosis, etc. Previous research found that the content of kinsenoside in wild-imitated cultivation A. roxburghii (WC) was similar to that of wild-tending cultivation plants (WP). This manuscript disentangled the relationship between kinsenoside and microbiome of A. roxburghii under wild-imitated environment.
Results
Our research found that endophytic bacteria’s diversity and network complexity decreased from WP to WC and tissue-cultured plants (TC). After 3 months of growth in the wild-imitated environment, the microbial composition of TC was significantly differentiated and converged toward WP. Correlation analyses showed that the diversity of bacterial community has a significant positive relationship with the content of kinsenoside, which is the main functional active ingredients in A. roxburghii, and BCP is the key taxa affecting kinsenoside. In addition, acetylacetyl-CoA reductase, a key enzyme for the synthesis of kinsenoside, was significantly enriched in WC and WP.
Conclusion
we proposed that the medicinal quality of A. roxburghii under the wild cultivation imitated method is comparable to wild tending cultivation ones with high kinsenoside content which is likely attributed to the activity of BCP and acetylacetyl-CoA. This study provides a basis for the improvement and sustainable utilization of A. roxburghii resources.
Enhancing Non-Communicable Disease Management in Elderly Families: A Community Outreach Initiative
Authors: Muflih Muflih , Suwarsi Suwarsi , Asmarani Fajarina Lathu , Erwanto Rizky , Amigo Thomas Aquino Erjinyuare 
Published: July 2023

Abstract
Background
Non-communicable diseases (NCDs) are a significant public health concern, particularly among elderly families. Limited access to healthcare resources and inadequate disease management exacerbate the impact of NCDs on this vulnerable population.
Objective
This study aimed to implement a community outreach initiative focused on enhancing non-communicable disease management in elderly families.
Methods
A comprehensive intervention was designed, including health education workshops, individualized health assessments, and the establishment of support networks. Pre- and post-intervention assessments were conducted to measure changes in knowledge levels, health status, health management practices, health behaviors, and family resilience among elderly families.
Results
Following the intervention, there was a substantial improvement in knowledge regarding NCDs and their management. Additionally, participants exhibited enhanced health status and more effective health management practices. Positive changes in health behaviors, such as regular exercise and balanced nutrition, were also observed. Moreover, family resilience significantly increased, strengthening their ability to cope with health challenges.
Conclusions
The community outreach initiative demonstrated significant positive outcomes in non-communicable disease management among elderly families. Targeted interventions can play a pivotal role in empowering this demographic, promoting their overall health and well-being, and fostering community-based healthcare efforts.
Optimization of phosphate oxygen isotope pretreatment measurement method based on phosphate in situ enrichment blanket
Authors: Li Sumei , Du Chengyu , Jin Xin , Yang Jing , Zhang Wei , Li Simin 
Published: July 2023

Abstract

Phosphate oxygen isotope analysis is an effective tool for investigating phosphorus migration and transformation in water bodies. Unfortunately, current pretreatment methods for this technology are significantly limited due to their demanding sample amount requirements, complex operation, and limited scope of application. In order to enhance the efficiency of the pretreatment process, hydrated zirconia was synthesized through liquid-phase precipitation. Zeolite, D001 macroporous resin, activated carbon, and ceramsite were chosen as possible candidate materials for loading purposes. The optimal zirconium loading material was identified through a combination of field enrichment and laboratory elution experiments. The ideal in situ enrichment duration, material dosages, and elution time were ascertained using response surface methodology. The findings showed that D001 resin exhibited superior selective adsorption and elution capacity for phosphate. The response surface optimization yielded the optimal parameters for the in situ phosphate-enrichment blanket: a mass of 13 g for zirconium-loaded D001 resin, an enrichment period of 360 min, and an elution period of 853 min. The attainment of a bright yellow Ag3PO4 solid after purification served as proof of the reliability of the optimization method. The obtained results provide a fundamental basis for the preparation and application of phosphate oxygen isotope analysis in freshwater ecosystem.
Aducanumab in Alzheimer’s Disease: A Critical Update
Authors: Ashique Sumel , Sirohi Ekta , Kumar Shubneesh , Rihan Mohd , Mishra Neeraj , Bhatt Shvetank , Gautam Rupesh K. , Singh Sachin Kumar , Gupta Gaurav , Chellappan Dinesh Kumar , Dua Kamal 
Published: July 2023

:
Alzheimer's disease (AD) is a complex neurological disorder that results in cognitive
decline. The incidence rates of AD have been increasing, particularly among individuals
60 years of age or older. In June 2021, the US FDA approved aducanumab, the first humanized
monoclonal antibody, as a potential therapeutic option for AD. Clinical trials have shown
this drug to effectively target the accumulation of Aβ (beta-amyloid) plaques in the brain, and
its effectiveness is dependent on the dosage and duration of treatment. Additionally, aducanumab
has been associated with improvements in cognitive function. Biogen, the pharmaceutical
company responsible for developing and marketing aducanumab, has positioned it as
a potential breakthrough for treating cerebral damage in AD. However, the drug has raised
concerns due to its high cost, limitations, and potential side effects. AD is a progressive neurological
condition that affects memory, cognitive function, and behaviour. It significantly impacts
the quality of life of patients and caregivers and strains healthcare systems. Ongoing research
focuses on developing disease-modifying therapies that can halt or slow down AD progression.
The pathogenesis of AD involves various molecular cascades and signaling pathways.
However, the formation of extracellular amyloid plaques is considered a critical mechanism
driving the development and progression of the disease. Aducanumab, as a monoclonal
antibody, has shown promising results in inhibiting amyloid plaque formation, which is the
primary pathological feature of AD. This review explores the signaling pathways and molecular
mechanisms through which aducanumab effectively prevents disease pathogenesis in AD.
The Protective Effect of Sanggenol L Against DMBA-induced Hamster
Buccal Pouch Carcinogenesis Induces Apoptosis and Inhibits Cell
Proliferative Signalling Pathway
Authors: Fu Qing , Zhang Fangming , Vijayalakshmi Annamalai 
Published: July 2023

Background:
Oral squamous cell carcinoma (OSCC) has a poor prognosis when treated
with surgery and chemotherapy. Therefore, a new therapy and preventative strategy for OSCC and
its underlying mechanisms are desperately needed. The purpose of this study was to examine the
chemopreventive effects of sanggenol L on oral squamous cell carcinoma (OSCC). The research
focused on molecular signalling pathways in 7,12-dimethylbenz(a)anthracene (DMBA)-induced
hamster buccal pouch (HBP) carcinogenesis.

Aim:
The purpose of this study was to look at the biochemical and chemopreventive effects of
sanggenol L on 7,12-dimethylbenz(a)anthracene (DMBA)-induced HBP (hamster buccal pouch)
carcinogenesis via cell proliferation and the apoptotic pathway.

Methods:
After developing squamous cell carcinoma, oral tumours continued to progress leftward
into the pouch 3 times per week for 10 weeks while being exposed to 0.5 % reactive DMBA three
times per week. Tumour growth was caused by biochemical abnormalities that induced inflammation,
increased cell proliferation, and decreased apoptosis.

Results:
Oral sanggenol L (10 mg/kg bw) supplementation with cancer-induced model DMBApainted
hamsters prevented tumour occurrences, improved biochemistry, inhibited inflammatory
markers, decreased cell proliferation marker expression of tumour necrosis factor-alpha (TNF- α),
nuclear factor (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and
induced apoptosis.

Conclusion:
Sanggenol L could be developed into a new medicine for the treatment of oral carcinogenesis.
Antimicrobial Peptides: Sources, Expression Systems, and Applications
Authors: Li Mengru , Lu Weitao , Sun Yanyan , Dong Chunming 
Published: July 2023

Abstract:
Antimicrobial peptides (AMPs) are widely sourced and have a variety of biological activities
such as broad-spectrum antibacterial, antiviral, and anticancer. Since AMPs are less likely
to cause drug resistance, they are expected to be an alternative to antibiotics. Compared with natural
extraction and chemical synthesis methods, producing AMPs using genetic engineering is a hot
research topic for the large-scale production of AMPs. This paper outlines the sources of AMPs, focuses
on different expression systems, and reviews the current status of AMPs applications in animal
husbandry, food preservation and Medicine, and agriculture to provide a theoretical basis and
support for using genetic engineering to express AMPs.
Recent Advancement in Bioactive Chalcone Hybrids as Potential Antimicrobial
Agents in Medicinal Chemistry
Authors: Maurya Anand , Agrawal Alka 
Published: July 2023

Abstract:
Chalcones are flavonoid-related aromatic ketones and enones generated from plants. The
chalcones have a wide range of biological activities, such as anti-tumor, calming, and antimicrobial
activities. In the present review, we have focused on the recently published original research articles
on chalcones as a unique antibacterial framework in medicinal chemistry.

:
Chalcones are structurally diverse moieties and can be split into simple and hybrid chalcones, with
both having core pharmacophore 1,3-diaryl-2-propen-1-one. Chalcones are isolated from natural
sources and also synthesized by using various methods. Their structure-activity relationship, mechanisms,
and list of patents are also summarized in this paper. This review article outlines the currently
published antimicrobial chalcone hybrids and suggests that chalcone derivatives may be potential
antimicrobial agents in the future.
QSAR Model based Gradient Boosting Regression of
N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Inhibitors for
Fructose-1,6-bisphosphatase
Authors: Zhao Ziyi , Yang Jialong , Ji Hongxiang , Liu Zeyu , Sun Tingting , NI Tongshang 
Published: July 2023

Background:
Due to the complication caused by conventional drugs, global attention has been
focused on the development of novel drugs. As a consequence, a potential theory to put T2DM under
control is of great medical significance.

Methods:
We used the heuristic method to establish the linear model and used Gradient Boosting Regression
to establish the nonlinear model of Fructose-1,6-Bisphosphatse inhibitor successively. In this study,
84 derivatives of N-Arylsulfonyl-Indole-2-Carboxamide were introduced into the models, and two outstanding
QSAR models with 2 molecule descriptors were established successfully.

Results:
Gradient Boosting Regression rendered a good correlation with R2
of 0.943 and MSE of 0.135
for the training set, 0.916 and 0.213 for the test set, which also proves the feasibility of the implementation
of the new method GBR in the field of QSAR. Meanwhile, the optimal model displayed wonderful
statistical significance.

Conclusion:
This study makes an attempt at the application of a new method of GBR in QSAR and
proves GBR as a promising tool for further study of CADD.
Metformin in Type 2 Diabetes: Evidence for its Beneficial Effects on
Frailty and Sarcopenia
Authors: Pyrgioti Elisavet E. , Karakousis Nikolaos D. , Georgakopoulos Petros N. , Papanas Nikolaos 
Published: July 2023

Abstract:
This narrative review aimed to discuss the potential interplay among frailty syndrome,
sarcopenia and metformin in type 2 diabetes mellitus (T2DM). There is emerging evidence on the
potential protective role of metformin on both frailty and sarcopenia. However, results are not always
consistent. Thus, further research is needed to provide a definitive answer on any role of metformin
in improving frailty and/or sarcopenia in T2DM.
Development of a New, Fully Validated LC-MS/MS Method for the Analysis
of Flibanserin in Pharmaceutical Preparations and Comparison of the
Chromatographic Performance with Six Stationary Phase Types
Authors: Geven Aysun , Özcan Saniye , Levent Serkan , Can Nafiz Öncü 
Published: July 2023

Background:
Initially synthesized as an antidepressant and potentially rapid onset of action,
flibanserin (FLB) was approved by the Food and Drug Administration (FDA) in August 2015 with a
warning to dispense the drug through a dedicated risk management program, despite the removal of
HSDD from the DSM-5TM. The drug is the first noteworthy FDA-approved drug for treating premenopausal
women with acquired, generalized HSDD.

Objective:
In literature, studies are plasma analyses or metabolite determinations to meet pharmacokinetic
analyses and some analytical targets. For this reason, in this thesis, a new method has been developed for
analysing FLB from pharmaceutical preparations, which is our target, providing all optimization conditions
and method validity parameters.

Methods:
The chromatographic separation was also investigated using Chromolith® and Ascentis® Express
models with a total of six stationary phases. The mobile phase mixture was acetonitrile:ammonium
formate (0.020 M, pH 6.0) and was used at the ratio (60:40, v/v). The optimum column temperature was
chosen as 40.0±0.1°C, and the autosampler thermostat temperature was chosen as 15±0.1°C. The sample
injection volume is optimized to be 1 μL.

Results:
The developed method is linear in the range of 2.63–105.0 ng/mL, and the regression coefficient
is 0.999 intraday and 0.986 interday. In the method, LOD and LOQ were obtained as 128 pg/mL and 384
pg/mL, respectively. In addition, the ANOVA P values were calculated as 0.586 and 0.914, respectively,
in the validation studies conducted intraday and interday.

Conclusion:
FLB chromatographic behaviors were studied and compared in detail with six different
stationary phases. The developed method was fully validated according to the ICH Q2 (R1) guideline, and
its pseudo-pharmaceutical formulation was analyzed.