bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data processing, analysis, and evaluation methods for co-design of coreless filament-wound building systems
Authors: Gil Pérez Marta , Mindermann Pascal , Zechmeister Christoph , Forster David , Guo Yanan , Hügle Sebastian , Kannenberg Fabian , Balangé Laura , Schwieger Volker , Middendorf Peter , Bischoff Manfred , Menges Achim , Gresser Götz T , Knippers Jan 
Published: June 2023

Abstract
The linear design workflow for structural systems, involving a multitude of iterative loops and specialists, obstructs disruptive innovations. During design iterations, vast amounts of data in different reference systems, origins, and significance are generated. This data is often not directly comparable or is not collected at all, which implies a great unused potential for advancements in the process. In this paper, a novel workflow to process and analyse the data sets in a unified reference frame is proposed. From this, differently sophisticated iteration loops can be derived. The developed methods are presented within a case study using coreless filament winding as an exemplary fabrication process within an architectural context. This additive manufacturing process, using fiber-reinforced plastics, exhibits great potential for efficient structures when its intrinsic parameter variations can be minimized. The presented method aims to make data sets comparable by identifying the steps each data set needs to undergo (acquisition, pre-processing, mapping, post-processing, analysis, and evaluation). These processes are imperative to provide the means to find domain interrelations, which in the future can provide quantitative results that will help to inform the design process, making it more reliable, and allowing for the reduction of safety factors. The results of the case study demonstrate the data set processes, proving the necessity of these methods for the comprehensive inter-domain data comparison.
Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis
Authors: Liu Ran , Dou Zhen , Tian Tian , Gao Xinjiao , Chen Lili , Yuan Xiao , Wang Chunyue , Hao Jiahe , Gui Ping , Mullen McKay , Aikhionbare Felix , Niu Liwen , Bi Guoqiang , Zou Peng , Zhang Xuan , Fu Chuanhai , Yao Xuebiao , Zang Jianye , Liu Xing 
Published: June 2023

Abstract
In mitosis, accurate chromosome segregation depends on the kinetochore, a supermolecular machinery that couples dynamic spindle microtubules to centromeric chromatin. However, the structure–activity relationship of the constitutive centromere-associated network (CCAN) during mitosis remains uncharacterized. Building on our recent cryo-electron microscopic analyses of human CCAN structure, we investigated how dynamic phosphorylation of human CENP-N regulates accurate chromosome segregation. Our mass spectrometric analyses revealed mitotic phosphorylation of CENP-N by CDK1, which modulates the CENP-L–CENP-N interaction for accurate chromosome segregation and CCAN organization. Perturbation of CENP-N phosphorylation is shown to prevent proper chromosome alignment and activate the spindle assembly checkpoint. These analyses provide mechanistic insight into a previously undefined link between the centromere–kinetochore network and accurate chromosome segregation.
From Refugees to Citizens? How Refugee Youth in the Dadaab Camps of Kenya Use Education to Challenge Their Status as Non-Citizens
Authors: Aden Hassan , Edle Abdirahman , Horst Cindy 
Published: June 2023

AbstractThe Dadaab camps of Kenya have ‘warehoused’ refugees from Somalia and elsewhere since 1991, providing their inhabitants with little hope to (re)gain the legal rights, participation, and membership that citizenship provides. Refugee youth in Dadaab hope that education can enable their access to citizenship rights—in particular, physical mobility and the right to work. Drawing on ethnographic research, semi-structured interviews, and life history interviews conducted in Dadaab and Mogadishu, this article discusses how refugee youth from Dadaab attempt to challenge their status as non-citizens through secondary education. Our study underscores that achieving citizenship rights, as well as civic participation and belonging, are key aspirations for these young people independent of whether they remain in Dadaab or (re)turn to Mogadishu. Yet, their ideas about what these key aspects of citizenship are and how to achieve them shift with their geographical location and in the presence or absence of citizenship rights.
Two-stage estimation and bias-corrected empirical likelihood in a partially linear single-index varying-coefficient model
Authors: Xue Liugen 
Published: June 2023

AbstractThe estimation and empirical likelihood (EL) of the parameters of interest in a partially linear single-index varying-coefficient model are studied. A two-stage method is presented to estimate the regression parameters and the coefficient functions. The asymptotic distributions of the proposed estimators are obtained. Meanwhile, a bias-corrected EL ratio for the regression parameters is proposed. It is shown that the ratio is asymptotically standard chi-squared. The result can be directly used to construct the EL confidence regions of the regression parameters. Simulation studies are carried out to evaluate the finite sample behaviour of the proposed method. An application example of a real data set is given.
Bayesian estimation of real-time epidemic growth rates using Gaussian processes: local dynamics of SARS-CoV-2 in England
Authors: Guzmán-Rincón Laura M , Hill Edward M , Dyson Louise , Tildesley Michael J , Keeling Matt J 
Published: June 2023

Abstract
Quantitative assessments of the recent state of an epidemic and short-term projections for the near future are key public-health tools that have substantial policy impacts, helping to determine if existing control measures are sufficient or need to be strengthened. Key to these quantitative assessments is the ability to rapidly and robustly measure the speed with which an epidemic is growing or decaying. Frequently, epidemiological trends are addressed in terms of the (time-varying) reproductive number R. Here, we take a more parsimonious approach and calculate the exponential growth rate, r, using a Bayesian hierarchical model to fit a Gaussian process to the epidemiological data. We show how the method can be employed when only case data from positive tests are available, and the improvement gained by including the total number of tests as a measure of the heterogeneous testing effort. Although the methods are generic, we apply them to SARS-CoV-2 cases and testing in England, making use of the available high-resolution spatio-temporal data to determine long-term patterns of national growth, highlight regional growth, and spatial heterogeneity.
Survey Consent to Administrative Data Linkage: Five Experiments on Wording and Format
Authors: Jäckle Annette , Burton Jonathan , Couper Mick P , Crossley Thomas F , Walzenbach Sandra 
Published: June 2023

Abstract
To maximize the value of the data while minimizing respondent burden, survey data are increasingly linked to administrative records. Record linkage often requires the informed consent of survey respondents and failure to obtain consent reduces sample size and may lead to selection bias. Relatively little is known about how best to word and format consent requests in surveys. We conducted a series of experiments in a probability household panel and an online access panel to understand how various features of the design of the consent request can affect informed consent. We experimentally varied: (i) the readability of the consent request, (ii) placement of the consent request in the survey, (iii) consent as default versus the standard opt-in consent question, (iv) offering additional information, and (v) a priming treatment focusing on trust in the data holder. For each experiment, we examine the effects of the treatments on consent rates, objective understanding of the consent request (measured with knowledge test questions), subjective understanding (how well the respondent felt they understood the request), confidence in their decision, response times, and whether they read any of the additional information materials. We find that the default wording and offering additional information do not increase consent rates. Improving the readability of the consent question increases objective understanding but does not increase the consent rate. However, asking for consent early in the survey and priming respondents to consider their trust in the administrative data holder both increase consent rates without negatively affecting understanding of the request.
What If God is a ‘Pagan Amalgam’: Marilynne Robinson and Historical Bible Scholarship
Authors: Douglas Christopher 
Published: June 2023

Abstract
Marilynne Robinson is one of the most influential Christian writers and public intellectuals alive today, and her views on a range of topics should be taken seriously. In her 2015 essay entitled ‘Memory’, she argues that the ‘liberal side’ of American Christianity has retreated from scriptural theology under pressure from academic biblical criticism. Her dismissal of Hebrew Bible scholarship is centred on two primary and interrelated ideas. First is the idea that Israelite religion was embedded in a broader context of Ancient Near East (ANE) religious cultures, such that biblical stories and characters sometimes borrow from other ancient sources. Second is the problem that the scholarly understanding of ancient Israelite polytheism threatens to make God into a ‘pagan amalgam’. The interrelated problem, that is, is the uniqueness and transcendence of the Hebrew Bible, and the God who is its main character. In this article, I review the scholarship on ancient Israelite religion and Robinson’s complaints about it. I argue that Robinson treats the critical scholarship only at a distance, allusively, (mis)representing it and sometimes (mis)understanding it in superficial ways, but that her theological anxiety is warranted.
Lasiurus villosissimus(Chiroptera: Vespertilionidae)
Authors: Díaz M Mónica , Núñez-Rodríguez Álvaro , Allendes Juan Luis , Barquez Rubén M , Rodríguez-San Pedro Annia 
Published: June 2023

AbstractThe South American hoary bat, Lasiurus villosissimus (É. Geoffroy Saint-Hilaire, 1806), is a vespertilionid bat, endemic to South America and occurring in all countries except Guyana, French Guiana, and Suriname. It is one of the four species included in the subgenus Aeorestes. Lasiurus villosissimus is distinguishable from all other species of the genus by its larger size and coloration (except Lasiurus cinereus, but it only occurs in Mexico, Central America, and the Hawaiian Islands). Pelage is dark brownish and grayish mixed with yellow, tinged with white, producing a frosty or hoary appearance which is always evident. It is an insectivorous species that inhabits a great variety of habitats.
P53-negative status and gross total resection as predictive factors for autologous tumor vaccine treatment in newly diagnosed glioblastoma patients
Authors: Yamada Erika , Ishikawa Eiichi , Miyazaki Tsubasa , Miki Shunichiro , Sugii Narushi , Kohzuki Hidehiro , Tsurubuchi Takao , Sakamoto Noriaki , Watanabe Shinya , Matsuda Masahide 
Published: June 2023

Abstract

Background
Among primary brain tumors, glioblastoma (GBM) is the most common and aggressive in adults, with limited treatment options. Our previous study showed that autologous formalin-fixed tumor vaccine (AFTV) contributed to prognostic improvements in newly diagnosed GBM patients. However, some patients died early despite the treatment. The discovery of predictive factors in the treatment was warranted for efficient patient recruitment and studies to overcome resistance mechanisms. Identifying prognostic factors will establish AFTV guidelines for patients who may respond to the therapy.

Methods
Data from 58 patients with newly diagnosed GBM, including 29 who received standard therapy plus AFTV (AFTV group) and 29 who received standard treatment (control group) were analyzed. Several data including patient age, sex, the extent of removal, and various cell immunohistochemistry (IHC) parameters were also included in the analysis.

Results
Both univariate and multivariate analyses revealed that gross total resection (GTR) and negative p53 were associated with a better prognosis only in the AFTV group. In the IHC parameters, CD8 staining status was also one of the predictive factors in the univariate analysis. For blood cell-related data, lymphocyte counts of 1100 or more and monocyte counts of 280 or more before chemo-radiotherapy were significant factors for good prognosis in the univariate analysis.

Conclusions
A p53-negative status in IHC and GTR were the predictive factors for AFTV treatment in newly diagnosed GBM patients. Microenvironment-targeted treatment and pretreatment blood cell status may be key factors to enhance therapy effects.
N4-acetylation of cytidine in mRNA plays essential roles in plants
Authors: Wang Wenlei , Liu Huijie , Wang Feifei , Liu Xiaoye , Sun Yu , Zhao Jie , Zhu Changhua , Gan Lijun , Yu Jinping , Witte Claus-Peter , Chen Mingjia 
Published: June 2023

Abstract
The biological function of RNA can be modulated by base modifications. Here, we unveiled the occurrence of N4-acetylation of cytidine in plant RNA, including mRNA, by employing LC-MS/MS and acRIP-seq. We identified 325 acetylated transcripts from the leaves of 4-week-old Arabidopsis (Arabidopsis thaliana) plants and determined that 2 partially redundant N-ACETYLTRANSFERASEs FOR CYTIDINE IN RNA (ACYR1 and ACYR2), which are homologous to mammalian NAT10, are required for acetylating RNA in vivo. A double-null mutant was embryo lethal, while eliminating 3 of the 4 ACYR alleles led to defects in leaf development. These phenotypes could be traced back to the reduced acetylation and concomitant destabilization of the transcript of TOUGH, which is required for miRNA processing. These findings indicate that N4-acetylation of cytidine is a modulator of RNA function with a critical role in plant development and likely many other processes.
A Lipopolysaccharide O-Antigen Synthesis Gene in Mesorhizobium huakuii Plays Differentiated Roles in Root Nodule Symbiotic Compatibility with Astragalus sinicus
Authors: Tang Zhide , Cai Shuyun , Liu Yuan , Li Dongzhi , Xie Fuli , Lin Hui , Chen Dasong , Li Youguo 
Published: June 2023

Lipopolysaccharide (LPS) is a ubiquitous microbial-associated molecular pattern. Plants can sense the three components of LPS, including core polysaccharide, lipid A, and O-antigen. LPS biosynthesis is an essential factor for the successful establishment of symbiosis in the rhizobium–legume plant system. The MCHK_1752 gene ( Mesorhizobium huakuii 7653R gene) encodes O-antigen polymerase and affects the synthesis of O-antigen. Here, we investigated the symbiotic phenotypes of six Astragalus sinicus accessions inoculated with the MCHK_1752 deletion mutant strain. The results revealed that the MCHK_1752 deletion mutant strain had a suppressing effect on the symbiotic nitrogen fixation of two A. sinicus accessions, a promoting effect in three A. sinicus accessions, and no significant effect in one A. sinicus accessions. In addition, the effect of MCHK_1752 on the phenotype was confirmed by its complementary strains and LPS exogenous application. Deletion of MCHK_1752 showed no effect on the growth of a strain, but affected biofilm formation and led to higher susceptibility to stress in a strain. At the early symbiotic stage, Xinzi formed more infection threads and nodule primordia than Shengzhong under inoculation with the mutant, which might be an important reason for the final symbiotic phenotype. A comparison of early transcriptome data between Xinzi and Shengzhong also confirmed the phenotype at the early symbiotic stage. Our results suggest that O-antigen synthesis genes influence symbiotic compatibility during symbiotic nitrogen fixation. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
The effects of intermittent fasting and a low-carbohydrate diet on type 2 diabetes
Authors: Pelc Miri Ann 
Published: June 2023

ABSTRACT
Type 2 diabetes is a known complication of obesity and a financial burden on the US healthcare system. The 2022 American Diabetes Association (ADA) guidelines support reducing overall carbohydrate intake for patients with type 2 diabetes to improve hyperglycemia. The ADA has no recommendations about intermittent fasting for patients with type 2 diabetes. This article describes a patient who successfully and safely used a low-carbohydrate diet and intermittent fasting and was able to discontinue medications for type 2 diabetes.
Systemic lupus erythematosus
Authors: El Hussein Mohamed Toufic , Wong Cayla 
Published: June 2023

Abstract:
Drug therapy for patients with systemic lupus erythematosus (SLE) aims to decrease symptom severity. Pharmacologic interventions are divided into four categories: antimalarials, glucocorticoids (GCs), immunosuppressants (ISs), and biological agents. Hydroxychloroquine, the most commonly used antimalarial treatment for this disease, is a mainstay in treating all patients with SLE. The multitude of adverse reactions of GCs has led clinicians to minimize their dosages or discontinue them whenever possible. To speed up the discontinuation or minimization of GCs, ISs are used for their steroid-sparing properties. Furthermore, certain ISs such as cyclophosphamide are recommended as maintenance agents to prevent flares and reduce the reoccurrence and severity of the disease state. Biological agents are recommended when other treatment options have failed due to intolerance or inefficacy. This article presents pharmacologic approaches for managing SLE in patients based on clinical practice guidelines and data from randomized controlled trials.
The Use of Artificial Intelligence Tools to Prepare Medical School Applications
Authors: Hashimoto Daniel A. , Johnson Kevin B. 
Published: June 2023

Advances in artificial intelligence (AI) have been changing the landscape in daily life and the practice of medicine. As these tools have evolved to become consumer-friendly, AI has become more accessible to many individuals, including applicants to medical school. With the rise of AI models capable of generating complex passages of text, questions have arisen regarding the appropriateness of using such tools to assist in the preparation of medical school applications.
In this commentary, the authors offer a brief history of AI tools in medicine and describe large language models, a form of AI capable of generating natural language text passages. They question whether AI assistance should be considered inappropriate in preparing applications and compare it with the assistance some applicants receive from family, physician friends, or consultants. They call for clearer guidelines on what forms of assistance—human and technological—are permitted in the preparation of medical school applications. They recommend that medical schools steer away from blanket bans on AI tools in medical education and instead consider mechanisms for knowledge sharing about AI between students and faculty members, incorporation of AI tools into assignments, and the development of curricula to teach the use of AI tools as a competency.
Easing the Entry of Qualified International Medical Graduates to U.S. Medical Practice
Authors: Andrews John S. , Ryan Amber L. , Elliott Victoria Stagg , Brotherton Sarah E. 
Published: June 2023

Abstract
Almost one quarter of physicians and physicians-in-training in the United States are international medical graduates (IMGs), meaning they have graduated from a medical school not accredited in the United States. Some IMGs are U.S. citizens and others are foreign nationals. IMGs, many of whom have years of training and experience gained in their countries of origin, have long contributed to the U.S. health care system, especially by providing care to populations that have been historically underserved. Additionally, many IMGs contribute to the diversity of the health care workforce, which can enhance the health of the population. The diversity of the United States is increasing, and racial and ethnic concordance between a physician and a patient has been linked to improved health outcomes.
IMGs must meet national- and state-level licensing and credentialing standards like any other U.S. physician. This assures the ongoing quality of the care provided by the medical workforce and protects the public. However, at the state level, variation in standards and standards that may be more challenging to meet than those for U.S. medical school graduates may hamper IMGs’ contributions. IMGs who are not U.S. citizens also face visa and immigration barriers.
In this article, the authors present insights gleaned from Minnesota’s model IMG integration program as well as changes made in 2 states in response to the COVID-19 pandemic. Improving and streamlining processes for IMGs to be licensed and credentialed as well as the policies governing visas and immigration, where appropriate, can ensure that IMGs will be willing and able to continue to practice when and where they are needed. This, in turn, could increase the contribution of IMGs to addressing health care inequities, improving health care access through service in federally designated Health Professional Shortage Areas, and reducing the impact of potential physician shortages.
Role of External Fixator Assistance in Tibial Rotation Osteotomy—Technique and Results
Authors: Bor Noam , Dujovny Eytan , Rozen Nimrod , Rubin Guy 
Published: June 2023

Background:
Idiopathic torsional deformities in children tend to resolve without intervention; however, pathologic torsion, which is primarily associated with neuromuscular diseases, requires surgical correction. We present a technique to assess the magnitude of tibial rotational osteotomy intraoperatively based on clinically simulating the degree of correction.

Methods:
A surgical technique is described, and a review of 8 rotational deformities of the tibia in 7 patients is presented. The data being collected included age, sex, date of surgery, diagnosis, and the magnitude of rotational deformity preoperatively and postoperatively.

Results:
There were 7 patients, of which 3 were females. The mean age was 10.5 years (5.5–18 y). The mean preoperative medial tibial rotation deformity in 7 segments was 20° (10–30°), and a lateral rotation of 40° was present in another segment. All deformities except one were corrected to an average of 10° external rotation.

Conclusions:
Our method differs from that of the common method used by most surgeons, in which pins are inserted before the tibial osteotomy at a predetermined angle, which represents the amount of desired final correction. We believe that the technique we present is easier on the surgeon, and the clinical results meet the planned presurgical expectations.