bluuebunny/crossref_metadata_2025_split huggingface dataset:
The learning curve for a novel, fluoroscopy‐based robotic‐assisted total hip arthroplasty system
Authors: Buchan Graham B. J. , Hecht Christian J. , Lawrie Charles M. , Sculco Peter K. , Kamath Atul F. 
Published: April 2023

AbstractBackgroundAdoption of robotic‐assisted total hip arthroplasty (RA‐THA) systems can improve the accuracy of acetabular cup placement, but no group has reported the learning curve of novel, fluoroscopy‐based RA‐THA systems.MethodsA learning‐curve cumulative summation (LC‐CUSUM) analysis was performed on a consecutive series of the first 100 patients who received fluoroscopy‐based RA‐THA by the study surgeon. Operative times and specific robotic timepoints were compared between learning and proficiency phases.ResultsImplementation of fluoroscopy‐based RA‐THA was associated with a learning curve of 12 cases. A 6‐min increase in operative time was seen during the learning phase compared to the proficiency phase (44.3 ± 4.4 vs. 38.0 ± 7.1 min; p < 0.001), with a 3‐min longer robotic cup impaction sequence during the learning phase (7.8 ± 1.9 vs. 4.8 ± 1.3 min; p < 0.001).ConclusionAdoption of fluoroscopy‐based RA‐THA is associated with a brief learning curve of 12 cases, with the most significant improvements in surgical efficiency realised during acetabular cup placement.
Single Atom‐Engineered NIR‐II Gold Clusters with Ultrahigh Brightness and Stability for Acute Kidney Injury
Authors: Huang You , Chen Ke , Liu Ling , Ma Huizhen , Zhang Xiaoning , Tan Kexin , Li Yuan , Liu Ying , Liu Changlong , Wang Hao , Zhang Xiao‐Dong 
Published: April 2023

AbstractNear‐infrared‐II (NIR‐II) imaging has shown great potential for monitoring the pathological progression and deep tissue imaging but is limited to present unmet NIR‐II agent. Present fluorophores show a promising prospect for NIR‐II imaging, but brightness and photostability are still highly challenging during real‐time monitoring. In this work, atom‐engineered NIR‐II Au24Cd1 clusters with ultrahigh brightness, stability, and photostability are developed via single atomic Cd doping. Single atom Cd substitutions contribute to Cd 4d state in HOMO and redistribution of energy level near the gap, exhibiting 56‐fold fluorescence enhancement of Au24Cd1 clusters. Meanwhile, single atomic Cd reinforces CdAu bond energy, formation energy, and stabilized cluster structure, leading to persistent stability for up to 1 month without decay, as well as excellent photostability of 1 h without photobleaching, much longer than clinically approved indocyanine green (<5 min). In vivo imaging shows gold clusters can monitor acute kidney injury (AKI) even after 72 h of injury, enabling evaluating progression at a very long window. Meanwhile, the bioactive gold clusters can alleviate AKI‐induced oxidative stress damage and acute neuroinflammation. Single atom‐engineered gold clusters exhibit molecular tracking and diagnostic prospect in kidney‐related diseases.
Rational Construction of Heterostructured Cu3P@TiO2 Nanoarray for High‐Efficiency Electrochemical Nitrite Reduction to Ammonia
Authors: Cai Zhengwei , Zhao Donglin , Fan Xiaoya , Zhang Longcheng , Liang Jie , Li Zixiao , Li Jun , Luo Yongsong , Zheng Dongdong , Wang Yan , Li Tingshuai , Yan Hong , Ying Binwu , Sun Shengjun , Alshehri Abdulmohsen Ali , Yan Hong , Xu Jia , Kong Qingquan , Sun Xuping 
Published: April 2023

AbstractElectroreduction of nitrite (NO2−) to valuable ammonia (NH3) offers a sustainable and green approach for NH3 synthesis. Here, a Cu3P@TiO2 heterostructure is rationally constructed as an active catalyst for selective NO2−‐to‐NH3 electroreduction, with rich nanosized Cu3P anchored on a TiO2 nanoribbon array on Ti plate (Cu3P@TiO2/TP). When performed in the 0.1 m NaOH with 0.1 m NaNO2, the Cu3P@TiO2/TP electrode obtains a large NH3 yield of 1583.4 µmol h−1 cm−2 and a high Faradaic efficiency of 97.1%. More importantly, Cu3P@TiO2/TP also delivers remarkable long‐term stability for 50 h electrolysis. Theoretical calculations indicate that intermediate adsorption/conversion processes on Cu3P@TiO2 interfaces are synergistically optimized, substantially facilitating the conversion of NO2−‐to‐NH3.
Haplotyping interspecific hybrids by dual alignment to both parental genomes
Authors: Brown Pat J. 
Published: April 2023

AbstractSequencing‐based genotyping of heterozygous diploids requires sufficient depth to accurately call heterozygous genotypes. In interspecific hybrids, alignment of reads to both parental genomes simultaneously can generate haploid data, potentially eliminating the problem of heterozygosity. Two populations of interspecific hybrid rootstocks of walnut (Juglans) and pistachio (Pistacia) were genotyped using alignment to the maternal genome, paternal genome, and dual alignment to both genomes simultaneously. Downsampling was used to examine concordance of imputed genotype calls as a function of sequencing depth. Dual alignment resulted in datasets essentially free of heterozygous genotypes, simplifying the identification and removal of cross‐contaminated samples. Concordance between full and downsampled genotype calls was always highest after dual alignment. Nearly all single nucleotide polymorphisms (SNPs) in dual alignment datasets were shared with the corresponding single‐parent datasets, but 60%–90% of single‐parent SNPs were private to that dataset. Private SNPs in single‐parent datasets had higher rates of heterozygosity, lower levels of concordance, and were enriched in fixed differences between parental genomes (“homeo‐SNPs”) compared to shared SNPs in the same dataset. In multi‐parental walnut hybrids, the paternal‐aligned dataset was ineffective at resolving population structure in the maternal parent. Overall, the dual alignment strategy effectively produced phased, haploid data, increasing data quality and reducing cost.
Imaging in gynecological disease (25): clinical and ultrasound characteristics of intramural pregnancy
Authors: Nijjar S. , Bottomley C. , Jauniaux E. , Jurkovic D. 
Published: April 2023

ABSTRACTObjectiveTo describe the clinical and sonographic characteristics of intramural pregnancy, as well as the available management options and treatment outcomes.MethodsThis was a retrospective single‐center study of consecutive patients with a sonographic diagnosis of intramural pregnancy between November 2008 and November 2022. An intramural pregnancy was diagnosed on ultrasound when a pregnancy was implanted within the uterine corpus, above the level of the internal cervical os and separate from the interstitial section of the Fallopian tube, and extended beyond the decidual–myometrial junction. Clinical, ultrasound, relevant surgical and histological information and outcomes were retrieved from each patient's record and analyzed.ResultsEighteen patients were diagnosed with an intramural pregnancy during the study period. Their median age was 35 (range, 28–43) years and the median gestational age at diagnosis was 8 + 1 (range, 5 + 5 to 12 + 0) weeks. Vaginal bleeding with or without abdominal pain was the most common presenting symptom, recorded in eight patients. Nine (50%) patients had a partial and nine (50%) had a complete intramural pregnancy. Embryonic cardiac activity was present in eight (44%) pregnancies. The majority of pregnancies (n = 10 (56%)) were initially managed conservatively, including expectant management in eight (44%) cases, local injection of methotrexate in one (6%) and embryocide in one (6%). Conservative management was successful in nine of the 10 (90%) pregnancies, with a median time to serum human chorionic gonadotropin resolution of 71 (range, 35–143) days. One patient with an ongoing live pregnancy had an emergency hysterectomy for a major vaginal bleed at 20 weeks' gestation. No other patient managed conservatively experienced any significant complication. The remaining eight (44%) patients had primary surgical treatment, comprising transcervical suction curettage in seven (88%) of these cases, while one patient presented with uterine rupture and underwent emergency laparoscopy and repair.ConclusionsWe describe the ultrasound features of partial and complete intramural pregnancy, demonstrating key diagnostic features. Our series suggests that, when intramural pregnancy is diagnosed before 12 weeks' gestation, it can be managed either conservatively or by surgery, with preservation of reproductive function in most women. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Bioproduction and applications of aldobionic acids with a focus on maltobionic and cellobionic acid
Authors: Bieringer Emmeran , García Vázquez Uxía , Klein Luisa , Moretó Bravo Núria , Tobler Matthias , Weuster-Botz Dirk 
Published: April 2023

AbstractAldobionic acids are sugar acids which consist of a disaccharide with an anomeric acid group. The most famous is lactobionic acid (LBA). LBA is used in many applications such as food and beverages, pharmaceuticals and medicine, cosmetics or chemical processes. During the last decade, all these industries are observing a shift of consumer preferences towards plant-based options. Thus, the biotechnological industry is trying to replace the animal-derived LBA. Maltobionic acid (MBA) and cellobionic acid (CBA) are two stereoisomers of LBA which have emerged as vegan alternatives. However, MBA and CBA face different obstacles related to their industrial production. While traditionally used electrochemical or chemical catalysis often rely on cost intensive and/or hazardous catalysts, novel production methods with microorganisms are still poorly studied. In the first part, this paper discusses both alternatives in terms of their characteristics and applications. In the second part, it reviews the long-studied chemical production and the novel bioproduction methods, which are based on enzymatic and microbial systems. This review concludes with a discussion of future work needed to bring their production to the industrial scale.
Cost-effectiveness analysis alongside the inter-B-NHL ritux 2010 trial: rituximab in children and adolescents with B cell non-Hodgkin’s lymphoma
Authors: Lueza Béranger , Aupérin Anne , Rigaud Charlotte , Gross Thomas G. , Pillon Marta , Delgado Rafael F. , Uyttebroeck Anne , Amos Burke G. A. , Zsíros József , Csóka Monika , Simonin Mathieu , Patte Catherine , Minard-Colin Véronique , Bonastre Julia 
Published: April 2023

Abstract
Objectives
The randomized controlled trial Inter-B-NHL ritux 2010 showed overall survival (OS) benefit and event-free survival (EFS) benefit with the addition of rituximab to standard Lymphomes Malins B (LMB) chemotherapy in children and adolescents with high-risk, mature B cell non-Hodgkin’s lymphoma. Our aim was to assess the cost-effectiveness of rituximab-chemotherapy versus chemotherapy alone in the French setting.

Methods
We used a decision-analytic semi-Markov model with four health states and 1-month cycles. Resource use was prospectively collected in the Inter-B-NHL ritux 2010 trial (NCT01516580). Transition probabilities were assessed from patient-level data from the trial (n = 328). In the base case analysis, direct medical costs from the French National Insurance Scheme and life-years (LYs) were computed in both arms over a 3-year time horizon. Incremental net monetary benefit and cost-effectiveness acceptability curve were computed through a probabilistic sensitivity analysis. Deterministic sensitivity analysis and several sensitivity analyses on key assumptions were also conducted, including one exploratory analysis with quality-adjusted life years as the health outcome.

Results
OS and EFS benefits shown in the Inter-B-NHL ritux 2010 trial translated into the model by rituximab-chemotherapy being the most effective and also the least expensive strategy over the chemotherapy strategy. The mean difference in LYs between arms was 0.13 [95% CI 0.02; 0.25], and the mean cost difference € − 3 710 [95% CI € − 17,877; € 10,525] in favor of rituximab-chemotherapy group. For a € 50,000 per LY willingness-to-pay threshold, the probability of the rituximab-chemotherapy strategy being cost-effective was 91.1%. All sensitivity analyses confirmed these findings.

Conclusion
Adding rituximab to LMB chemotherapy in children and adolescents with high-risk mature B-cell non-Hodgkin's lymphoma is highly cost-effective in France.

Trial registration
ClinicalTrials.gov identifier: NCT01516580.
A Mathematical Analysis of the Intermediate Behaviour of the Energy Cascades of Quantum Turbulence
Authors: Jou David , Sciacca Michele 
Published: April 2023

AbstractWe propose a mathematical interpolation between several regimes of energy cascade in quantum turbulence in He II. On the basis of a physical interpretation of such mathematical expression we discuss in which conditions it is expected to appear an intermediate $k^{2}$

k
2

regime (equipartition regime) in the transition region between the hydrodynamic regime and the Kelvin wave regime (namely, between the $k^{-5/3}$

k

−
5
/
3

and $k^{-1}$

k

−
1

regions in coflow situations and between the $k^{-3}$

k

−
3

and $k^{-1}$

k

−
1

regions in counterflow situations). It is seen that if the energy rate transfer from the hydrodynamic region to the Kelvin wave region is sufficiently slow, such equipartition region will be present, but for higher values of such energy rate transfer it will disappear. For high rates of the energy rate transfer, the transition regime between the hydrodynamic and the Kelvin wave regimes will be monotonous, characterized by a negative exponent of $k$
k
between $-5/3$
−
5
/
3
and −1 (or between −3 and −1), instead of the positive 2 exponent of the equipartition regime.
Regional communication and media analysis of aquaculture in Atlantic islands
Authors: Machado Patrícia C. , Pinto Bruno , Nogueira Natacha 
Published: April 2023

AbstractThe way the media portrays aquaculture-related events can influence how this industry is perceived by the public and affect its success. Since media are an important source of public information, media content analysis has been carried out in several regions of the world. This study aimed to determine which aspects of aquaculture were more exposed and how they were discussed by regional media in the Madeira archipelago, an oceanic group of Portuguese islands. Analysis of aquaculture’s media coverage in the two most-read regional newspapers of Madeira was carried out over a 5-year period (2017 to 2021). For each news article, the assessment focused on the geographic scope, the main topics covered, the stakeholders with access to the debate, and the general tone of the article (risk/benefit framework). A total of 297 articles were analyzed. Results indicate the occurrence of trigger events that contributed to a shift in the amount of news published and in the way media framed aquaculture. In general, political and economic issues dominated the coverage, whereas social, environmental, scientific, and landscape matters received less media attention. The voice of the government was predominant throughout the 5 years in analysis and aquaculture was generally framed with a balanced tone, slightly more negative. Open and transparent communication between the stakeholders and the media is fundamental for the sustainable development of the aquaculture industry.
In our (frozen) backyard: the Eurasian Union and regional environmental governance in the Arctic
Authors: Hartwell Christopher A. 
Published: April 2023

AbstractRegional environmental governance has emerged as a viable alternative to supranational environmental solutions, using regional and local knowledge and actors to tailor more effective policies. This does not deny a role for supranational institutions, however, which can enable their members to effectively shift towards such a decentralized and polycentric approach. In specific regions such as the Arctic, with many national and local actors interested in environmental improvement, such impetus from meta-organizations (i.e., organizations comprised of organizations) could result in beneficial environmental outcomes. This paper examines an underutilized institution, the Eurasian Union (EaEU), and the role it currently plays in facilitating regional environmental governance. Focusing on its largest member, Russia—and the only member with an Arctic linkage—I explore the tension between supranational facilitation and interference in an area not directly affecting all members. Despite explicit Russian interest in this realm, the EaEU may be able to influence Russian environmental policy for the better via multilateral means and internal mechanisms. By challenging the Russian monopoly on Arctic policy in the EaEU, these additional voices may create space for environmental innovation in areas not central to Russia’s interests.
Selecting the species to be used in lichen transplant surveys of air pollution in Tunisia
Authors: Chahloul Nadia , Khadhri Ayda , Vannini Andrea , Mendili Mohamed , Raies Aly , Loppi Stefano 
Published: April 2023

AbstractThis study was undertaken with the aim of selecting one or more lichen species that are the most suitable for transplant-based surveys of air pollution in Tunisia, in areas where the local native lichen vegetation is scanty or missing at all. To this purpose, four epiphytic (tree inhabiting) lichen species (Evernia prunastri, Flavoparmelia caperata, Parmotrema perlatum, Ramalina farinacea) were collected from the Babouch forests, a remote and unpolluted area of NW Tunisia, and analyzed for their content of potentially toxic elements (PTEs), namely Al, As, Cd, Cr, Cu, Fe, Ni, Pb, Sb, and Zn, by ICP-MS. Moreover, also the physiological status of the lichen samples was evaluated by measuring their chlorophyll content, photosynthetic efficiency, and spectral reflectance. The results indicated a remarkable contribution of airborne soil and dust particles to the total PTE content, especially for the foliose species F. caperata and P. perlatum. The fruticose lichens E. prunastri and R. farinacea had a lower and similar content of PTEs, and hence were regarded as more suitable to be used in transplant studies, since are able to detect even minimal accumulation amounts. All lichen species were healthy, as emerged from the analysis of physiological parameters.
‘I wish to participate but…’: investigating students’ perceptions of student-staff pedagogical partnerships at a Hong Kong University
Authors: Dai Kun , Matthews Kelly E. , Liang Yifei 
Published: April 2023

AbstractThere is an increasing focus on relationship-rich education and relational pedagogies in higher education. Engaging students as partners (SaP) to nurture values-based pedagogical relationships is one such approach, yet it is contested with limited research outside of Anglophone countries. To advance a collective understanding of SaP as a global practice, we interviewed 35 postgraduate students at a research-intensive university in Hong Kong with a hybridised educational setting combining Chinese and westernised strategies and heritages. Reflecting on their learner-teacher relationships as both undergraduate and postgraduate students, they discussed differing senses of student identity that shaped how they perceived their pedagogical relationships: entanglement of positioning themselves as followers, customers, and co-teachers. The influence of neoliberalism, capitalism, and marketisation of higher education in the Hong Kong context was evident throughout the interviews. We discuss the implications for learner-teacher relationships as a pedagogical partnership in the broader hybridised higher education context of Hong Kong. In doing so, we argue that students are navigating an in-betweenness that shapes how they see themselves and the pedagogical relationships they form with teaching staff.
Introduction: Sustainability, Democracy and the Dark Sides of Civil Society
Authors: Machin Amanda , Ruser Alexander 
Published: April 2023

AbstractDespite widespread acknowledgement of the value of sustainability, the transition towards more sustainable economies and societies remains a challenge around the world. Civil societies play an important role not only in supporting government efforts on sustainability by ‘filling gaps’ and raising social awareness, but also in pioneering new practices and disrupting particular governmental or corporate strategies, as well as engaging and empowering previously marginalised individuals and groups. Yet civil society is not always a champion of sustainability nor of democracy; these actors may of course also destabilise innovations, depoliticise sustainability issues by reifying certain concepts or approaches and reinforce social hierarchies and patterns of exclusion that can undermine any transformative potential and bolster the unsustainable status quo. This Special Issue is therefore dedicated to interrogating what we see as the ambiguous, yet critical, role played by civil societies in sustainability politics. This introductory paper intends not only to draw attention to some of the arguments, theories and challenges found in each of the individual papers collected here, but also to pull on the common threads that run through them, as well as to unpick some of the different uses of the key terminology that they employ. We aim, moreover, to highlight the inevitable tension between the ‘democratic side’ and the ‘dark side’ of civil society and its politics of sustainability.
Information and decision support needs: A survey of women interested in receiving planned oocyte cryopreservation information
Authors: Sandhu Sherine , Hickey Martha , Braat Sabine , Hammarberg Karin , Lew Raelia , Fisher Jane , Ledger William , Peate Michelle ,   on behalf of the Eggsurance Collaborative Group, Agresta F , Lieberman D , Anderson R , Norman R , Hart R , Johnson L , Michelmore J , Parle A , Summers F , Allingham C 
Published: April 2023

Abstract
Purpose
Identifying the information and decision support needs of women interested in receiving planned oocyte cryopreservation (POC) information.

Methods
An online survey of Australian women, aged 18-45, interested in receiving POC information, proficient in English, with internet access. The survey covered POC information sources, information delivery preferences, POC and age-related infertility knowledge (study-specific scale), Decisional Conflict Scale (DCS), and time spent considering POC. Target sample size (n=120) was determined using a precision-based method.

Results
Of 332 participants, 249 (75%) had considered POC, whilst 83 (25%) had not. Over half (54%) had searched for POC information. Fertility clinic websites were predominately used (70%). Most (73%) believed women should receive POC information between ages 19-30 years. Preferred information providers were fertility specialists (85%) and primary care physicians (81%). Other methods rated most useful to deliver POC information were online. Mean knowledge score was 8.9/14 (SD:2.3). For participants who had considered POC, mean DCS score was 57.1/100 (SD:27.2) and 78% had high decisional conflict (score >37.5). In regression, lower DCS scores were associated with every 1-point increase in knowledge score (-2.4; 95% CI [-3.9, -0.8]), consulting an IVF specialist (-17.5; [-28.0, -7.1]), and making a POC decision (-18.4; [-27.5, -9.3]). Median time to decision was 24-months (IQR: 12.0-36.0) (n=53).

Conclusion
Women interested in receiving POC information had knowledge gaps, and wanted to be informed about the option by age 30 years from healthcare professionals and online resources. Most women who considered using POC had high decisional conflict indicating a need for decision support.