bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive aspergillosis in the patient with focal segmental glomerulosclerosis initiating hemodialysis: a case report and mini-review
Authors: Sato Noriaki , Yokoi Hideki , Ichioka Mitsuhiro , Ishii Akira , Matsubara Takeshi , Yanagita Motoko 
Published: December 2022

Abstract
Background
Invasive aspergillosis (IA) is a severe form of fungal infection caused by the genus Aspergillus in immunocompromised hosts and has a high mortality rate. End-stage kidney disease (ESKD) is one of the risk factors for developing fungal infection; however, the detailed clinical and treatment course of ESKD patients with IA has been scarcely reported, especially for the patient initiating hemodialysis (HD). Here, we experienced a patient under immunosuppressive therapy for focal segmental glomerulosclerosis (FSGS) who suffered from IA involving lung and brain and resulted in initiating HD.

Case presentation
A 66-year-old male patient with a history of suspected non-tuberculosis mycobacterial lung disease was initially admitted to the hospital with minimal change disease and subsequently diagnosed as FSGS with worsening urinary protein levels. The combined treatment including immunosuppressive treatments of cyclosporin and glucocorticoids and low-density lipoprotein apheresis was initiated, and then, he experienced the symptoms of dry cough, somnolence, and disorientation, which were subsequently diagnosed as IA involving lung and brain. The patient required renal replacement therapy, and maintenance HD was continued. Despite the intensive treatment with multiple antifungals of liposomal amphotericin B, voriconazole, micafungin, and amphotericin B, the pneumonia of the patient did not improve, and he subsequently passed away.

Conclusions
We report the case of the IA under immunosuppressive treatment, who was subsequently initiated maintenance HD. The detailed clinical course of medications used to treat the patient is presented with the literature review of IA in ESKD and HD patients and those with past acid-fast bacterial infections. The careful determination of the intensity of immunosuppression and monitoring of the patient’s symptoms and early definitive diagnosis is crucial in treating IA in immunocompromised hosts with ESKD or in HD under immunosuppressive treatment, as the mortality for these patients is suspected to be high despite the intensive treatment.
Histopathological and immunohistochemical studies on the influence of orally administration monosodium glutamate, a food additive dependent on time in vivo
Authors: Hamad Sherin Ramadan 
Published: December 2022

Abstract
Background
Monosodium glutamate is a widely used flavor enhancer/food additive in meat, fish, milk and cheese or vegetable origins. Our present study aimed to assess the effect of utilization monosodium glutamate on the cardiac, splenic, hepatic and renal organs in mice. Thirty animals were divided into three groups: control group; glutamate 10 treated groups and glutamate 15 treated group. The experimental period was two successive weeks.

Results
Oral administrations of monosodium glutamate for 10 days induced moderate histopathological changes in cardiac, splenic, hepatic and renal tissues and also resulted in significant increase of the nuclear factor-kB expression depend on time of administration as compared to the control group, while treatment with monosodium glutamate for 14 days resulted in severe histopathological changes as well as highly significant increase of the nuclear factor-kB expression as compared to the control group.

Conclusions
It could be concluded that oral administration of monosodium glutamate induced histopathological alterations, and cytotoxicity in cardiac, splenic, hepatic and renal tissues dependent on time.
Primary therapy of early breast cancer: Egyptian view of 2021 St. Gallen consensus
Authors: Khaled Hussein , Nada Yousry Wasef , Ramadan Kareem Mohamed , Fekry Shawkat , Seleam Mohamed Samy , Gaafar Rabab , Lotayef Mohamed 
Published: December 2022

Abstract
Purpose
The theme of the St. Gallen International Breast Cancer Conference 2021 held virtually for the first time, due to the COVID-19 pandemic, was on tailoring therapies for patients with early breast cancer. A monkey survey that included an Egyptian Panel voted on most of the questions of the original St. Gallen consensus, and some added new questions most relevant to oncology practice in the country, to be able to compare voting results that reflect differences in breast cancer management and decision making.

Methods
The panel included 74 Egyptian scientists from different oncology specialties. Management issues including controversial diagnostic and therapeutic interventions were prepared by a small committee and then projected using the online monkey survey website: https://www.surveymonkey.com. The survey included 130 questions. Results were then analyzed, tabulated, and compared to the voting results of the original St. Gallen consensus.

Results and conclusions
Voting questions and resulting percentages of answers from the Egyptian panel were summarized. There was no consensus between the Egyptian and the original St. Gallen panels on 28/130 statements. They mostly included genetic and pathologic aspects, specifically the routine use of gene signature assays and a few queries involving surgical, radiotherapeutic, and systemic interventions. Probably, available resources and healthcare system differences in Egypt compared to European and the USA were the cause of these differences. This would also be applicable to other low- and low-middle-income healthcare scenarios present in many countries, especially with the present constraints of the COVID-19 pandemic.
A comparative investigation of the sorption of polycyclic aromatic hydrocarbons to various polydisperse micro- and nanoplastics using a novel third-phase partition method
Authors: Emecheta Emeka Ephraim , Borda Diana Borda , Pfohl Patrizia Marie , Wohlleben Wendel , Hutzler Christoph , Haase Andrea , Roloff Alexander 
Published: December 2022

AbstractEvidence for direct adverse effects of micro- and nanoplastic particles (MNPs) on human health is scarce, but it has been hypothesized that MNPs act as carriers for environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Many studies have already investigated the sorption of PAHs to microplastics, typically using the batch-equilibrium method. Here we established a novel third-phase partition (TPP) method utilizing thermo-extractable polydimethylsiloxane-coated stir-bars as re-usable passive samplers to compare the sorption of PAHs to 17 different MNPs. This method facilitates the quantification of MNP-sorbed pollutants, including those with poor water-solubility without requiring laborious filtration and solvent-extraction steps. Using benzo[a]pyrene (B[a]P) as a representative PAH, sorption kinetics and isotherms for MNPs were evaluated. B[a]P sorption was generally strong but differed by over two-orders of magnitude, clustering according to polymer types in the order of polyamides > polyethylenes ≫ Tire Rubber > polyurethanes > polymethyl methacrylate. B[a]P sorption was diminished for photo-aged MNPs. Within given polymer types, properties including particle size, polarity/hydrophobicity and chain mobility notably influenced B[a]P sorption. When comparing different PAHs, their sorption to selected MNPs increased over five-orders of magnitude with hydrophobicity: anthracene < B[a]P < dibenzo[a,l]pyrene. Our data is an important contribution to the understanding of the sorption behaviors of MNPs. The novel TPP-method represents a universally-applicable approach for the reliable evaluation of sorption characteristics of contaminants and MNPs, and can be easily adapted to desorption studies.Graphical Abstract
Practice, theory and the animation studies continuum
Authors: Harris Miriam , Moore Samantha 
Published: December 2022

This editorial explores how advancements in the sphere of practice-based research, and university programmes supporting this realm of inquiry, have contributed to an increased confidence in the ways in which animation practitioners discuss and reflect upon their work, drawing upon a range of theories and methodologies. References are made to Paul Ward’s essay ‘Some thoughts on practice-theory relationships in animation studies’ (2006), and there is a consideration of his preference for a ‘weak classification’ approach – one that acknowledges animation’s rich eclecticism – rather than maintain rigid boundaries. Ward’s ideas are informed by sociologist Basil Bernstein’s theories, and he also draws upon Mike Wayne’s study of media production practices, to advocate for the ‘critical practitioner’, as compared to the more circumscribed ‘reflexive’ – with a tendency to focus upon the minutiae of technology – and ‘theoretical’ practitioner, who dwells upon the importance of the text. Instead, the ‘critical practitioner’ possesses the skills to reflect upon what they do and why, and contextualise the work from a social, historical and political perspective.
Further developments in animation studies over the last fifteen years have included an increase in texts that thoughtfully yoke both practice and theory, including essays by Claudia Hart, Paul Wells and Johnny Hardstaff’s book Re-Imagining Animation: The Changing Face of Moving Image (2008) and Aylish Wood’s essay ‘Behind the scenes: A study of Autodesk Maya’ (2014). The editorial provides details about the essays contained within this particular edition, and the ways in which they evidence the thinking of the ‘critical practitioner’, by drawing upon a diverse range of sources, and integrating a perceptive discussion of both practice and theory.
Pengaruh Variasi Organic Loading Rate Limbah Buah Jeruk Terhadap Konversi Biohidrogen pada Reaktor Kontinyu Sirkulasi
Authors: Sinaga Nazarruddin , Farizan Praevia Muhammad 
Published: December 2022

Salah satu energi alternatif terbarukan saat ini yang sedang dikembangkan untuk mengganti bahan bakar fosil adalah biohidrogen. Biohidrogen dapat diperoleh dari hasil fermentasi limbah biomassa berupa limbah jeruk. Jeruk mengandung senyawa yang dapat diolah untuk menghasilkan hidrogen melalui fermentasi anearob. Penelitian ini bertujuan untuk mengetahui pengaruh variasi Organic Loading Rate limbah buah jeruk yang diumpankan setiap harinya ke dalam biodigester terhadap produksi gas hidrogen yang dihasilkan. Gas hidrogen merupakan suatu senyawa yang memilki potensi yang cukup menjanjikan sebagai salah satu sumber energi untuk di masa depan. Energi dari hasil kalor pembakaran hidrogen ini mencapai 120,1 MJ/Kg, dimana angka ini bahkan hampir tiga kali lipat lebih besar dari energi yang dihasilkan pembakaran gasoline. Variasi Organic Loading Rate yang digunakan pada penelitian ini adalah 2,25 L/hari dan 2,75 L/hari. Hasil penelitian menunjukkan adanya pengaruh organic loading rate terhadap produksi biohidrogen. Semakin besar OLR maka semakin besar gas hidrogen yang terbentuk. Hasil gas hidrogen yang diperoleh yaitu sebesar 11,728 %. Konversi limbah biomassa menjadi gas hidrogen dinilai mendukung konsep Waste to Energy pemerintah dan menjadi salah satu solusi energi alternatif di Indonesia. Gas hidrogen selanjutnya dapat dikonversi menjadi panas dan listrik. One of kinds of renewable alternative energy source that can be developed to substitute fossil fuels is biohydrogen. Biohydrogen is obtained from the fermentation of biomass, orange waste. Oranges contain compounds that can be treated to produce hydrogen through anaerob fermentation. This research aims to determine the effect of organic rate’s variation of oranges that inputted per day to the biodigester. Organic loading rate that been used in this research were 2,25 L/day and 2,75 L/day. The results show that the influence of organic loading rate to biohydrogen production. The results reveal that the higher the OLR is, the more hydrogen is produced. The production of hydrogen on OLR 2.75 L is higher than OLR 2.25 L. The hydrogen production’s concentration is 11.728 %. The conversion of biomass waste into hydrogen gas is considered to support Indonesia governments about Waste to Energy concept and become one of the alternative energy solutions in Indonesia. Hydrogen gas can then be converted into heat and electricity.
Pembuatan Briket Arang Dari Kombinasi Bonggol Jagung Dan Tempurung Kelapa Dengan Polyvinyl Acetate (PVAc) sebagai Perekat
Authors: Rachma Asmaa Mufiida , Supriyo Edy 
Published: December 2022

Kebutuhan bahan bakar di Indonesia semakin lama semakin meningkat dikarenakan aktivitas masyarakat yang juga semakin meningkat. Akibatnya bahan bakar yang tidak terbarukan semakin menipis dan menjadi ancaman serius bagi masyarakat. Salah satu energi alternatif yang dapat dilakukan adalah penggunaan biomassa. Biomassa ini dapat mengatasi kelangkaan bahan bakar fosil karena ketersediaan bahan yang melimpah di Indonesia. Limbah pertanian digunakan sebagai bahan bakar alternatif karena melimpah dan tidak dimanfaatkan secara optimal. Tempurung kelapa dan bonggol jagung merupakan contoh dari limbah padat pertanian yang tiap tahunnya bertambah produksinya. Maka dari itu kedua bahan tersebut digunakan sebagai bahan alternatif pembuatan briket arang pengganti bahan bakar fosil. Briket arang merupakan bahan bakar berbentuk padat yang mengandung karbon, menyala dalam waktu yang cukup lama, serta memiliki nilai kalor yang tinggi. Tempurung kelapa dan bonggol jagung diolah menjadi arang dan ditambah pengikat serta dilakukan pengolahan lebih lanjut untuk dijadikan briket. Perekat yang digunakan adalah perekat PVAc (Polyvinyl Acetate). Penelitian ini menggunakan metode factorial design dengan 8 percobaan dan variasi suhu yang digunakan 400oC dan 500oC. Hasil penelitian menunjukkan bahwa variasi briket yang terbaik adalah variasi 10 gram tempurung kelapa dan 8 gram bonggol jagung dengan suhu karbonisasi 500oC, briket ini memiliki nilai kalor 7220,12 Cal/g, kadar abu 7,913%, dan kadar air 7,1%. The need for fuel in Indonesia is increasing over time due to increasing community activities. As a result, non-renewable fuels are running low and become a serious threat to society. One alternative energy that can be done is the use of biomass. This biomass can overcome the scarcity of fossil fuels due to the availability of abundant materials in Indonesia. Agricultural waste is used as an alternative fuel because it is abundant and not used optimally. Coconut shells and corn cobs are examples of agricultural solid wastes which increase in production every year. Therefore, these two materials are used as alternative materials for making charcoal briquettes to replace fossil fuels. Charcoal briquettes are solid fuels that contain carbon, burn for a long time, and have a high calorific value. Coconut shells and corn cobs are processed into charcoal and added with binders and further processing is carried out to make briquettes. The adhesive used is PVAc (Polyvinyl Acetate) adhesive. This study used the factorial design method with 8 experiments and the temperature variations used were 400oC and 500oC. The results showed that the best variation of briquettes was the variation of 10 grams of coconut shell and 8 grams of corn cobs with a carbonization temperature of 500oC, these briquettes had a calorific value of 7220.12 Cal/g, ash content of 7.913%, and water content of 7.1%.
Pengaruh Massa Adsorben Blending CaO Dari Cangkang Telur dan Karbon Teraktivasi untuk Adsorpsi Zat Warna Methylene Blue
Authors: Oko Syarifuddin , Kurniawan Andri , Angreni Dewi 
Published: December 2022

Industri tekstil merupakan salah satu penyebab pencemaran lingkungan akibat zat warna yang digunakan dalam proses pencelupan tekstil. Limbah zat warna yang dihasilkan oleh industri tekstil merupakan senyawa organik non-biodegradable yang dapat mencemari lingkungan terutama pada lingkungan perairan. Methylene blue merupakan salah satu zat organik pencemar yang tidak dapat terurai karena terdapat gugus benzena yang sulit terdegradasi. Cara yang paling mudah untuk mengolah limbah cair industri tekstil adalah dengan cara adsorpsi. Cangkang telur adalah salah satu adsorben yang murah dan mudah didapat, juga adsorben lain yang digunakan adalah karbon aktif. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh massa adsorben CaO:C terhadap efisiensi adsorpsi dan penurunan konsentrasi zat warna methylene blue. Cangkang telur terlebih dahulu di kalsinasi menggunakan furnace pada suhu 800oC selama 4 jam. Ukuran cangkang telur dan karbon aktif ialah 100 mesh. Adsorpsi dilakukan dengan rasio CaO:C yaitu 2:8 dan memvariasikan massa adsorben yaitu 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10; 10,5 dan 11 gram. Proses adsorpsi dilakukan selama waktu kontak 60 menit dalam konsentrasi zat warna methylene blue 100 ppm. Hasil penelitian menunjukkan massa adsorben optimum ada pada massa 10 gram dengan konsentrasi akhir methylene blue 0,0139 ppm dan efisiensi adsorpsi 99,9861 %. Society need for clothing has increased, which results in an increased number of factories in the textile industry. The textile industry is one of the causes of environmental pollution due to dyes used in the textile dyeing process. Dye waste produced by the textile industry is a non-biodegradable organic compound that can pollute the environment, especially in the aquatic environment. Methylene blue is one of the polluting organic substances that cannot decompose because there is a benzene group that is difficult to degrade. The alternative for handling the dye waste of the textile industry is the adsorption. Egg shells used because abundant amounts and are economical, and other adsorbens used are activated carbon. This study was to determine the effect of cao:c adsorben mass on adsorption efficiency and decreased concentration of methylene blue. The egg shell is first calcined using a furnace at a temperature of 800oC for 4 hours. The size of the egg shell and activated carbon is 100 mesh. Adsorption is carried out with a CaO:C ratio of 2:8 and varies the mass of adsorbens which is 0,5; 1; 1,5; 2; 2,5; 3; 3,5; 4; 6; 8; 10; 10,5 and 11 grams. The adsorption process is carried out during a contact time of 60 minutes at a concentration of methylene blue 100 ppm. The results showed the optimum adsorbens mass was at 10 grams with reduced the methylene blue concentration to 0,0139 ppm and the adsorption capacity obtained was 99,9861%.
One-third of patients with eclampsia at term do not have an abnormal angiogenic profile
Authors: Chaiworapongsa Tinnakorn , Romero Roberto , Gotsch Francesca , Gomez-Lopez Nardhy , Suksai Manaphat , Gallo Dahiana M. , Jung Eunjung , Levenson Dustyn , Tarca Adi L. 
Published: December 2022

Abstract

Objectives
An abnormal angiogenic profile is present in about one-half of women with preeclampsia at term. Few studies examined the roles of angiogenic biomarkers in eclampsia. The aims of this study were to determine (1) whether the degree of an anti-angiogenic state, reflected by a low placental growth factor (PlGF) to soluble fms-like tyrosine kinase-1 (sFlt-1) ratio, in women with eclampsia differed from that of women with severe preeclampsia; and (2) the prevalence of women who had an abnormal angiogenic profile at the diagnoses of preterm and term eclampsia.

Methods
A cross-sectional study was conducted to include women in the following groups: (1) uncomplicated pregnancy (n=40); (2) severe preeclampsia (n=50); and (3) eclampsia (n=35). Maternal serum concentrations of PlGF and sFlt-1 were determined by immunoassays.

Results
Women with preterm, but not term, eclampsia had a more severe anti-angiogenic state than those with severe preeclampsia (lower PlGF and PlGF/sFlt-1 ratio, each p<0.05). However, the difference diminished in magnitude with increasing gestational age (interaction, p=0.005). An abnormal angiogenic profile was present in 95% (19/20) of women with preterm eclampsia but in only 67% (10/15) of women with eclampsia at term.

Conclusions
Angiogenic biomarkers can be used for risk assessment of preterm eclampsia. By contrast, a normal profile of angiogenic biomarkers cannot reliably exclude patients at risk for eclampsia at term. This observation has major clinical implications given that angiogenic biomarkers are frequently used in the triage area as a test to rule out preeclampsia.
The Red Hen Anonymizer and the Red Hen Protocol for de-identifying audiovisual recordings
Authors: Khasbage Yash , Alcaraz Carrión Daniel , Hinnell Jennifer , Robertson Frankie , Singla Karan , Uhrig Peter , Turner Mark 
Published: December 2022

Abstract
Scientists of multimodal communication have no established policy or default tool for sharing de-identified audiovisual recordings. Recently, new technology has been developed that enables researchers to de-identify voice and appearance. These software tools can produce output in JSON format that specifies bodypose and face and hand keypoints in numerical form, suitable for computer search, machine learning, and sharing. The Red Hen Anonymizer is a new tool for de-identification. This article presents the Red Hen Anonymizer and discusses guidelines for its use.
Nesidioblastosis: an uncommon complication seen post Roux-en-Y gastric bypass
Authors: Kim Kiveum , Greenspan Jacob Lim , Mehrara Shaheen , Wynne David , Ennis Elizabeth 
Published: December 2022

Summary
Adult-onset nesidioblastosis is a rare complication of Roux-en-Y gastric bypass surgery and may occur months to years after the initial surgical procedure. It is manifested by a hyperinsulinemic, hypoglycemic state. The annual incidence of adult-onset hyperinsulinemic hypoglycemia is believed to be less than 0.1 in 1 000 000 with a mean age of onset of 47 years (1). Here, we describe a patient who presented with worsening hypoglycemic symptoms for 1 year prior to presentation that eventually progressed to hypoglycemic seizures. The onset of this hypoglycemia was 5 years after Roux-en-Y gastric bypass surgery. A full neurological evaluation, which included an EEG, head CT, and MRI, was performed to rule out epilepsy and other seizure-related disorders. After hypoglycemia was confirmed, extensive laboratory studies were obtained to elucidate the cause of the hypoglycemia and differentiate nesidioblastosis from insulinoma. Once the diagnosis of nesidioblastosis was established, a sub-total pancreatectomy was performed, and the patient was discharged and placed on acarbose, a competitive reversible inhibitor of pancreatic α-amylase and intestinal brush border α-glucosidases which slows carbohydrate absorption. The lack of information and understanding of nesidioblastosis due to its rarity makes any knowledge of this rare but important surgical complication essential. As incidence of obesity increases, the number of gastric bypasses being performed increases with it, and understanding this disease process will be essential for the primary care provider. This is the primary reason for the writing of this publication.

Learning points

Nesidioblastosis is a persistent hyperinsulinemic, hypoglycemic state, mostly seen after Roux-en-Y gastric bypass surgery, with symptoms occurring postprandially.

The incidence is 0.1–0.3% of all post Roux-en-Y gastric bypass patients.

The key diagnostic clue to identifying nesidioblastosis is a positive selective arterial calcium stimulation test, showing a diffuse pattern of increased basal hepatic venous insulin concentration, whereas insulinomas would show focal increases.

Pathological specimen of pancreas will show diffuse hypertrophy of beta cells.

Management includes acarbose and total or subtotal pancreatectomy, which can be curative.

With the prevalence of obesity increasing and more patients turning to Roux-en-Y gastric bypass, more patients may be at risk of this potential surgical complication.