bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics, clinical efficacy and safety of acetaminophen (paracetamol) in adult horses with naturally occurring chronic lameness
Authors: Mercer Melissa A. , Davis Jennifer L. , McKenzie Harold C. , Byron Christopher R. , Kelleher Maureen E. , Trager Lauren , Cecere Thomas E. , Wilson Katie E. , Council‐Troche R. M. , Werre Stephen R. 
Published: June 2023

AbstractBackgroundAcetaminophen is used clinically in horses with musculoskeletal pain; however, no studies have been performed in horses with chronic lameness.ObjectivesTo determine the pharmacokinetics, safety and efficacy of chronic dosing of acetaminophen in horses with naturally occurring chronic lameness.Study designLongitudinal.MethodsTwelve adult horses with chronic lameness were treated with acetaminophen (30 mg/kg PO) every 12 h for 21 days. Plasma concentrations of acetaminophen were analysed on days 7 and 21 via LC–MS/MS and noncompartmental pharmacokinetic analysis. Lameness was evaluated by body‐mounted inertial sensor (BMIS) and 10‐point subjective lameness score on day 21 and compared to untreated baseline evaluation on day 35. Clinicopathological analysis (n = 12), hepatic biopsy (n = 6) and gastroscopy (n = 6) were evaluated on days −1 and 22.ResultsMaximum plasma acetaminophen concentration (Cmax) was 20.83 ± 10.25 μg/mL at time (Tmax) 0.40 ± 0.22 h on day 7. The Cmax on day 21 was 17.33 ± 6.91 μg/mL with a Tmax of 0.67 ± 0.26 h. Subjective lameness scores significantly improved at 2 and 4 h post‐treatment; Significant percent improvement was detected in PDmax for horses with hindlimb lameness at 1, 2 and 8 h post‐treatment. There were no significant differences in gastroscopy or hepatic biopsy scores between days −1 and 22.Main limitationsSmall sample size, multi‐limb lameness of varying severity and aetiology, lack of intermediary lameness evaluation.ConclusionsIn horses with naturally occurring chronic lameness, acetaminophen at 30 mg/kg produced a transient improvement in subjective lameness and BMIS evaluation. Acetaminophen may not be effective as a monotherapy. Acetaminophen was safe following 21 days of 30 mg/kg PO every 12 h, with no evidence of clinically significant changes in clinicopathological analysis, hepatic biopsy or gastric ulceration scores.
A review on software and hardware developments in automatic epilepsy diagnosis usingEEGdatasets
Authors: Handa Palak , Gupta Esha , Muskan Satya , Goel Nidhi 
Published: June 2023

AbstractEpilepsy is a common non‐communicable, group of neurological disorders affecting more than 50 million individuals worldwide. Different approaches of basic, clinical, and translational research of the human brain have been explored to diagnose, treat, and manage the growing no. of cases of epilepsy. Various hospital information from video, images, signals, forms, and so forth, are retrieved and analysed to develop a consensus for such patients. Electroencephalography (EEG) tests are routinely used to diagnose the type of epilepsy in a clinical setting. Artificial Intelligence algorithms are assisting in the early detection and prediction of epileptic patterns observed in EEG signals. This paper reviews recent and emerging state‐of‐the‐art (SOTA) software and hardware approaches in data selection, signal processing, feature estimation, classification, detection methods, and evaluation metrics applied to open and private EEG datasets from 2014 to 2022. The work summarizes and compares reported works through subjective and objective parameters. Rise in hardware pipeline, start‐ups, and companies, deep learning methods in software pipeline and release of free EEG datasets have been observed from 2014 to 2022. SOTA advancements have shown immense potential and paved a path to successful real‐time detection, prediction, and management of epileptic seizures.
CO2 fertilization contributed more than half of the observed forest biomass increase in northern extra‐tropical land
Authors: He Yue , Liu Yongwen , Lei Lingjie , Terrer César , Huntingford Chris , Peñuelas Josep , Xu Hao , Piao Shilong 
Published: June 2023

AbstractThe existence of a large‐biomass carbon (C) sink in Northern Hemisphere extra‐tropical ecosystems (NHee) is well‐established, but the relative contribution of different potential drivers remains highly uncertain. Here we isolated the historical role of carbon dioxide (CO2) fertilization by integrating estimates from 24 CO2‐enrichment experiments, an ensemble of 10 dynamic global vegetation models (DGVMs) and two observation‐based biomass datasets. Application of the emergent constraint technique revealed that DGVMs underestimated the historical response of plant biomass to increasing [CO2] in forests () but overestimated the response in grasslands () since the 1850s. Combining the constrained (0.86 ± 0.28 kg C m−2 [100 ppm]−1) with observed forest biomass changes derived from inventories and satellites, we identified that CO2 fertilization alone accounted for more than half (54 ± 18% and 64 ± 21%, respectively) of the increase in biomass C storage since the 1990s. Our results indicate that CO2 fertilization dominated the forest biomass C sink over the past decades, and provide an essential step toward better understanding the key role of forests in land‐based policies for mitigating climate change.
The digitalisation of consumption and its geographies
Authors: Liu Chen 
Published: June 2023

AbstractAs consumer cultures become increasingly digital and the digital/data has become more commodified, geographers have turned their attention to researching the ways in which consumption spaces, socialities and subjectivities are (re)produced by the digitalisation of everyday life. This article investigates the relationships between the digital and geographies of consumption based on a close reading of recent studies on the promises, possibilities, challenges, and flaws of the intersections of the digital and consumption in geography. It connects the digitalisation of consumption with the tradition of mapping and doing geographies of consumption that is concerned with the social life of thing, and opens a conversation on how subjectivities, spatialities, and socialities of consumption are reproduced by the changes in digital spaces and practices in the mundane. This article also points to the potential of a ‘follow the digital’ approach for establishing a dynamic and multi‐sited understanding of geographies of consumption in the digital context.
Exploring the impact of engagement in mental health and substance use research: A scoping review and thematic analysis
Authors: Sheikhan Natasha Y. , Kuluski Kerry , McKee Shelby , Hiebert Melissa , Hawke Lisa D. 
Published: June 2023

AbstractBackgroundThere is growing evidence demonstrating the impact of engaging people with lived experience (PWLE) in health research. However, it remains unclear what evidence is available regarding the impact of engagement specific to mental health and substance use research.MethodsA scoping review of three databases and thematic analysis were conducted. Sixty‐one articles that described the impact of engagement in mental health and substance use research on either individual experiences or the research process were included.ResultsKey topics include (a) the impact of engagement on individual experiences; (b) the impact of engagement on the research process; and (c) facilitators and barriers to impactful engagement. Studies largely focused on the perceived positive impact of engagement on PWLE (e.g., personal and professional growth, empowering and rewarding experience, feeling heard and valued), researchers (e.g., rewarding experience, deeper understanding of research topic, changes to practice), and study participants (e.g., added value, fostered a safe space). Engagement activities were perceived to improve facets of the research process, such as improvements to research quality (e.g., rigour, trustworthiness, relevance to the community), research components (e.g., recruitment), and the research environment (e.g., shifted power dynamics). Facilitators and barriers were mapped onto the lived experience, researcher, team, and institutional levels. Commonly used terminologies for engagement and PWLE were discussed.ConclusionEngaging PWLE—from consultation to co‐creation throughout the research cycle—is perceived as having a positive impact on both the research process and individual experiences. Future research is needed to bring consistency to engagement, leverage the facilitators to engagement, and address the barriers, and in turn generate research findings that have value not only to the scientific community, but also to the people impacted by the science.Patient or Public ContributionPWLE were engaged throughout the scoping review process, including the screening phase, analysis phase, and write‐up phase.
In situ growth of SiC wires on CVI densification of SiC foam
Authors: Sreeja Remani , Shyin Palani Prabhakaran , Suchithra Cheriyan , Devapal Deepa , Prabhakaran Payyadakam Veetil 
Published: June 2023

AbstractSilicon carbide (SiC) foam prepared by polymer infiltration and pyrolysis (PIP) process was further densified with β‐SiC by chemical vapor infiltration (CVI) technique. Scanning electron microscopy and high‐resolution transmission electron microscopy images confirmed the presence of highly entangled and branched in situ grown SiC wires of uniform diameter (∼500 nm) over the struts of open‐cell SiC foam. A uniform rate increase in diameter from nanometer to micron range (∼11 μm) was observed with an increase in the CVI reaction period. X‐ray diffraction results showed the formation of highly crystalline β‐SiC structure along the <111> direction with stacking faults. The formation of SiC wires was explained by the vapor–liquid–solid mechanism and evenness of the surface and uniform growth rate of SiC confirmed the homogeneous concentration of gaseous species during CVI reaction. The compressive strength increased with relative density, with maximum values of 5.5 ± 1.26 MPa for ultimate SiC foam (ρ = 400 kg/m3) prepared by hybrid PIP/CVI technique. The thermo‐oxidative stability of the resultant foam was evaluated up to 1650°C under air and shows excellent thermal stability compared to SiC foam prepared by PIP route. The densified SiC foam can find potential applications in the field of hot gas filters, catalyst supports, microwave absorption properties, and heat insulation for high‐temperature applications.
Relationships examined: Parent and child readiness to change and sociodemographic characteristics in family based weight loss treatment
Authors: Ramel Melissa , Wilfley Denise E. , Tabak Rachel , Lew Daphne , Moursi Nasreen A. , Kilanowski Colleen , Cook Steven R. , Eneli Ihouma U. , Quattrin Teresa , Schechtman Kenneth B. , Epstein Leonard H. 
Published: June 2023

SummaryBackgroundFamily based treatment is an effective, multipronged approach to address obesity as it plagues families.ObjectiveTo investigate the relationships among sociodemographic characteristics (e.g., education and income), body mass index (BMI) and race/ethnicity with readiness to change for parents enrolled in the Primary care pediatrics, Learning, Activity and Nutrition (PLAN) study.MethodsMultivariate linear regressions tested two hypotheses: (1) White parents will have higher levels of baseline readiness to change, when compared to Black parents; (2) parents with higher income and education will have higher levels of readiness to change at baseline.ResultsA positive relationship exists between baseline parent BMI and readiness to change (Pearson correlation, 0.09,p < 0.05); statistically significant relationships exist between parent education level (−0.14,p < 0.05), income (0.04,p < 0.05) and readiness to change. Additionally, a statistically significant relationship exists, with both White (β, −0.10,p < 0.05), and Other, non‐Hispanic (−0.10,p < 0.05) parents exhibiting lower readiness to change than Black, non‐Hispanic parents. Child data did not indicate significant relationships between race/ethnicity and readiness to change.ConclusionsResults demonstrate that investigators should consider sociodemographic characteristic factors and different levels of readiness to change in participants enrolling in obesity interventions.
Comparing the resource implications of old and new colorectal adenoma surveillance guidelines in Australia
Authors: Ow Tsai‐Wing , Angelica Bianca , Burn Sophie , Chu Matthew , Lee Shawn Z. , Lin Richard , Tran Vy , Iyngkaran Guru , Bampton Peter , Sukocheva Olga , Tse Edmund , Rayner Chris K. 
Published: June 2023

AbstractBackgroundThe latest update to the Australian adenoma surveillance guideline in 2018 introduced a novel risk stratification system with updated surveillance recommendations. The resource implications of adopting this new system are unclear.AimsTo quanitfy the resource demands of adopting new over old adenoma surveillance guidelines.MethodsWe studied data from 2443 patients undergoing colonoscopies, in which a clinically significant lesion was identified in their latest, or previous procedure(s) across five Australian hospitals. We excluded procedures with inflammatory bowel disease, new or prior history of colorectal cancer or resection, inadequate bowel preparation and incomplete procedures. Old and new Australian surveillance intervals were calculated according to the number, size and histological characteristics of lesions identified. We used these data to compare the rate of procedures according to each guideline.ResultsBased on the procedures for 766 patients, the new surveillance guidelines significantly increased the number of procedures allocated an interval of 1 year (relative risk (RR): 1.57, P = 0.009) and 10 years (RR: 3.83, P < 0.00001) and reduced those allocated to half a year (RR: 0.08, P = 0.00219), 3 years (RR: 0.51, P < 0.00001) and 5 years (RR: 0.59, P < 0.00001). Overall, this reduced the relative number of surveillance procedures by 21% over 10 years (25.92 vs 32.78 procedures/100 patient‐years), which increased to 22% after excluding patients 75 or older at the time of surveillance (19.9 vs 25.65 procedures/100 patient‐years).ConclusionThe adoption of the latest Australian adenoma surveillance guidelines can reduce demand for surveillance colonoscopy by more than a fifth (21–22%) over 10 years.
Effects of home‐based chronic wound care training for patients and caregivers: A systematic review
Authors: Huang Yao , Hu Jiale , Xie Ting , Jiang Zhaoqi , Ding Wenjing , Mao Beiqian , Hou Lili 
Published: June 2023

AbstractWe aimed to review and synthesise the evidence of the interventions of patients' and informal caregivers' engagement in managing chronic wounds at home. The research team used a systematic review methodology based on an updated guideline for reporting systematic reviews (PRISMA) and recommendations from the Synthesis Without Meta‐analysis. Cochrane Central Register of Controlled Trial of the Cochrane Library, Pubmed, Embase, CINAHL, Wanfang (Chinese), and CNKI database (Chinese) were searched from inception to May 2022. The following MESH terms were used: wound healing, pressure ulcer, leg ulcer, diabetic foot, skin ulcer, surgical wound, educational, patient education, counselling, self‐care, self‐management, social support, and family caregiver. Experimental studies involving participants with chronic wounds (not at risk of wounds) and their informal caregivers were screened. Data were extracted and the narrative was synthesised from the findings of included studies. By screening the above databases, 790 studies were retrieved, and 16 met the inclusion and exclusion criteria. Studies were 6 RCTs and ten non‐RCTs. Outcomes of chronic wound management included patient indicators, wound indicators, and family/caregiver indicators. Home‐based interventions of patients or informal caregivers' engagement in managing chronic wounds at home may effectively improve patient outcomes and change wound care behaviour. What's more, educational/behavioural interventions were the primary type of intervention. Multiform integration of education and skills training on wound care and aetiology‐based treatment was delivered to patients and caregivers. Besides, there are no studies entirely targeting elderly patients. Home‐based chronic wound care training was important to patients with chronic wounds and their family caregivers, which may advance wound management outcomes. However, the findings of this systematic review were based on relatively small studies. We need more exploration of self and family‐oriented interventions in the future, especially for older people affected by chronic wounds.
How do trucking companies respond to announced versus unannounced safety crackdowns? The case of government inspection blitzes
Authors: Balthrop Andrew , Scott Alex , Miller Jason 
Published: June 2023

AbstractEnsuring motor carriers comply with safety rules is critical to the efficient workings of supply chains and the safety of the motoring public. However, little is understood regarding how carriers respond to changes in the likelihood of inspection (a.k.a., “crackdowns”) undertaken by the Department of Transportation. Drawing on the regulatory compliance and criminology literature, we extend the rational cheater explanation that undergirds carrier safety research by incorporating principles from attention‐based theory to devise new theoretical predictions regarding how carriers respond to announced versus unannounced inspection crackdowns. To test our theory, we rely on exogenous variation in the probability of inspection from the DOT's use of announced and unannounced inspection “blitzes.” We test predictions using a longitudinal dataset of nearly 10 million truck inspections from 2012 to 2016. We find firms with lower costs of compliance, and higher costs of avoiding inspections improve compliance prior to and during announced blitzes. Small firms with lower costs of avoidance tend to avoid announced blitzes. Unannounced blitzes result in no changes in compliance or avoidance, providing evidence that awareness is driving our results.
Anatomical targeting for electrode localization in subthalamic nucleus deep brain stimulation: A comparative study
Authors: Tonroe Thomas , McDermott Hugh , Pearce Patrick , Acevedo Nicola , Thevathasan Wesley , Xu San San , Bulluss Kristian , Perera Thushara 
Published: June 2023

AbstractBackground and PurposeIn deep brain stimulation (DBS), accurate electrode placement is essential for optimizing patient outcomes. Localizing electrodes enables insight into therapeutic outcomes and development of metrics for use in clinical trials. Methods of defining anatomical targets have been described with varying accuracy and objectivity. To assess variability in anatomical targeting, we compare four methods of defining an appropriate target for DBS of the subthalamic nucleus for Parkinson's disease.MethodsThe methods compared are direct visualization, red nucleus‐based indirect targeting, mid‐commissural point‐based indirect targeting, and automated template‐based targeting. This study assessed 226 hemispheres in 113 DBS recipients (39 females, 73 males, 62.2 ± 7.7 years). We utilized the electrode placement error (the Euclidean distance between the defined target and closest DBS electrode) as a metric for comparative analysis. Pairwise differences in electrode placement error across the four methods were compared using the Kruskal‐Wallis H‐test and Wilcoxon signed‐rank tests.ResultsInterquartile ranges of the differences in electrode placement error spanned 1.18‐1.56 mm. A Kruskal‐Wallis H‐test reported a statistically significant difference in the median of at least two groups (H(5) = 41.052, p < .001). Wilcoxon signed‐rank tests reported statistically significant difference in two comparisons: direct visualization versus red nucleus‐based indirect, and direct visualization versus automated template‐based methods (T < 9215, p < .001).ConclusionsAll methods were similarly discordant in their relative accuracy, despite having significant technical differences in their application. The differing protocols and technical aspects of each method, however, have the implication that one may be more practical depending on the clinical or research application at hand.
Time matters: The role of recovery for daily mood trajectories at work
Authors: Arnold Maike , Sonnentag Sabine 
Published: June 2023

AbstractTaking a temporal perspective, we examined how employees' mood (i.e., wakefulness‐tiredness, calmness‐tenseness, and pleasantness‐unpleasantness) develops during the workday and tested employees' daily recovery from work as a predictor of these mood trajectories. Specifically, we analysed a serial mediation model with evening recovery experiences (i.e., psychological detachment, relaxation, mastery experiences, and control) being indirectly related to the development of next‐day mood (i.e., linear slopes) via sleep quality and start‐of‐work mood. We collected data from 124 employees who completed up to 5 daily surveys over two workweeks. Multilevel growth curve models showed that, in general, wakefulness followed a negative quadratic, calmness a positive quadratic, and pleasantness no systematic trajectory during the workday. At the day level, path analyses showed that psychological detachment indirectly and relaxation directly predicted the three start‐of‐work mood states. Moreover, mastery experiences and control directly predicted start‐of‐work calmness. Additionally, psychological detachment and relaxation indirectly predicted the development of wakefulness and psychological detachment, relaxation, and mastery experiences indirectly predicted the development of calmness. Results suggest that some benefits of daily psychological detachment, relaxation (i.e., high start‐of‐work wakefulness and calmness), and mastery experiences (i.e., high start‐of‐work calmness) tend to subside during the workday.
Understanding employee work‐life conflict experiences: Self‐leadership responses involving resource management for balancing work, family, and professional development
Authors: Williams Ethlyn A. , McCombs Kate M. 
Published: June 2023

AbstractThe work–life conflict literature describes how employees manage conflict experiences, but little work has focused on experiences beyond work and family (or work and school) conflict to examine more broadly work, family, and professional development (e.g., when employees enter a graduate degree program). This study uses qualitative data to explore the work–life conflict experiences of employees undergoing professional career development in the form of gaining a graduate degree. We contribute to the literature on employees' work–life conflicts. To explore work–life conflicts, 41 semi‐structured interviews were conducted, and revealed that employees report three types of work–life conflict experiences—energizing, depleting and maintaining. Utilizing the conservation of resources theory, we link work–life conflict experiences with resource management and self‐leadership strategies enacted. We demonstrate that when employees report energizing experiences, they utilize behavioural strategies of self‐goal setting and self‐observation to acquire more resources. When employees report depleting experiences, they utilize constructive thought strategies for the evaluation of dysfunctional beliefs and self‐talk to recover from resource loss. Finally, when employees report maintaining experiences, they utilize natural rewards strategies to protect their stock of resources. The link between self‐leadership strategies and work–life conflicts plays a crucial role in understanding how conflict can be resolved.