bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuolar myopathy with monoclonal gammopathy and stiffness (VAMMGAS)
Authors: Staedler Katia , Allenbach Yves , Salort‐Campana Emmanuelle , Malfatti Edoardo , Rigolet Aude , Attarian Shahram , Maues de Paula André , Léonard‐Louis Sarah , Benveniste Olivier , Stojkovic Tanya 
Published: January 2025

AbstractBackgroundMonoclonal gammopathy (MG) has been reported in association with numerous neurological disorders but the spectrum of MG‐associated myopathies remains poorly described.ObjectiveTo report a newly acquired myopathy associated with MG.MethodsThree adult patients with the same phenotype from two French referral centers were prospectively analyzed. Clinical, electrophysiological, muscle biopsy data, and patients' outcomes under treatment are reported.ResultsThe patients, aged 37, 46, and 56 years, presented progressive weakness with subacute worsening and stiffness, in the context of severe weight loss. The weakness mainly involved the proximal limbs and axial muscles. Creatine kinase levels were 1400–2900 IU/L and electromyography revealed a myopathic pattern with spontaneous complex repetitive discharges. Muscle biopsies showed vacuoles containing glycogen and autophagic material along with the presence of sarcolemmal complement membrane attack complex deposits. There was no evidence of a genetic glycogen metabolic disorder. IgGκ monoclonal gammopathy was identified in all cases, without signs of lymphoplasmocytic proliferation. All patients improved with a treatment combining corticosteroids, intravenous immunoglobulins, and immunosuppressants, and two patients recovered walking ability.Conclusion and RelevanceWe report a new muscle disease defined by a vacuolar myopathy characterized by axial and proximal muscle weakness with prominent stiffness and high frequency discharges on electromyography associated with monoclonal gammopathy, defined under the acronym VAMMGAS.
Embracing the Future or Buying Into the Bubble: Do Sophisticated Institutions Invest in Crypto Assets?
Authors: DeVault Luke , Turtle H. J. , Wang Kainan 
Published: January 2025

ABSTRACTWe document that early institutional investors in cryptocurrencies exhibit innovation and adaptability in financial markets, despite the asset class's inherent ambiguity and risk. Investing in crypto assets signals a managerial willingness to undertake reputational and career risks. We compare the performance of institutions that engage in crypto investments with that of their non‐crypto‐investing peers. Our results indicate that institutional crypto investors outperform their peers by about 2.8% per year. Using propensity score matching, we find that early crypto investors outperform both followers and non‐holders as crypto investments become increasingly prevalent in markets.
Genetic Rescue of the Dinaric Lynx Population: Insights for Conservation From Genetic Monitoring and Individual‐Based Modelling
Authors: Pazhenkova Elena , Bartol Matej , Boljte Barbara , Fležar Urša , Gazzola Andrea , Gomerčić Tomislav , Konec Marjeta , Kos Ivan , Krofel Miha , Kubala Jakub , Paule Ladislav , Pop Mihai , Potočnik Hubert , Promberger Barbara , Rigg Robin , Sin Teodora , Sindičić Magda , Slijepčević Vedran , Stronen Astrid Vik , Topličanec Ira , Skrbinšek Tomaž 
Published: January 2025

ABSTRACTInbreeding depression poses a severe threat to small populations, leading to the fixation of deleterious mutations and decreased survival probability. While the establishment of natural gene flow between populations is an ideal long‐term solution, its practical implementation is often challenging. Reinforcement of populations by translocating individuals from larger populations is a viable strategy for reducing inbreeding, increasing genetic diversity and potentially saving populations from extinction. The Dinaric population of Eurasian lynx (Lynx lynx) has faced high inbreeding levels, with effective inbreeding reaching 0.316 in 2019, endangering the population's survival. To counteract this, population reinforcement was implemented between 2019 and 2023, involving the translocation of 12 individuals from the Carpathian Mountains to the Dinaric Mountains of Slovenia and Croatia. We conducted comprehensive genetic monitoring in this area, gathering 588 non‐invasive and tissue samples, which were used for individual identification and estimation of population genetic parameters. We used stochastic modelling to assess the long‐term viability of the Dinaric lynx population post‐translocation and formulate effective conservation strategies. The model predicts that, despite significant improvement of genetic diversity after translocations, inbreeding will return to critical levels within 45 years. Our results highlight the fact that reinforcement is just the first step and that long‐term genetic management is needed to keep the population from sliding back towards extinction. The Dinaric lynx population serves as a compelling example of genetic rescue. The lessons learnt here will be essential for ensuring the viability of the Dinaric lynx in the future and also provide a useful template for conservation of other populations and species facing similar threats.
Mode‐I Moving Semi‐Infinite Crack in an Infinitely Long Orthotropic Strip in the Presence of Electromagnetic Field
Authors: Alam Samim , Chandra Mandal Subhas 
Published: January 2025

ABSTRACTThis research examines the propagation of a mode‐I semi‐infinite crack with constant velocity in a magnetoelastic orthotropic strip with shear‐free boundaries. The novelty of this work lies in addressing the unexplored plane‐strain problem of crack propagation in a magnetoelastic orthotropic medium, specifically in the presence of electromagnetic field and shear‐free boundary conditions. The mixed boundary value problem is reduced to a Wiener‐Hopf equation by employing the Fourier integral transform method to the convenient boundary conditions. The Wiener‐Hopf equation is then solved for asymptotic cases to obtain the expressions of the stress intensity factor (SIF) and the crack opening displacement (COD) at the vicinity of the crack. The obtained results are demonstrated graphically. The key finding of this research is that the magnetoelastic coupling coefficient plays a critical role in influencing the behavior of dynamic fractures, as illustrated by graphical results. The accuracy and novelty of the findings are validated by comparison with previously published works, highlighting the added value of this research in understanding magnetoelastic effects on crack propagation.
Effectiveness of Y‐V‐plasty for refractory bladder neck stenosis after transurethral prostate surgery
Authors: Masumoto Hakaru , Horiguchi Akio , Shinchi Masayuki , Ojima Kenichiro , Segawa Yuhei , Takekawa Kazuki , Furukawa Yoshiyuki , Minami Takahiro , Suzuki Sadayoshi , Katsuta Jumpei , Watanabe Daisuke , Ito Keiichi 
Published: January 2025

ObjectivesTo evaluate the surgical and patient‐reported outcomes of YV‐plasty in patients with refractory bladder neck stenosis (BNS) following transurethral prostate surgery.MethodsThis retrospective study reviewed five patients who underwent YV‐plasty for BNS between January 2021 and October 2023. The surgical procedure involved a midline lower abdominal incision to expose the bladder neck. A V‐shaped incision was made in the anterior bladder wall to create a bladder flap. The bladder neck was then incised from the apex of the V‐shape to the healthy urethra, forming a Y‐shaped incision. Fibrotic tissue was excised, and the posterior side of the urethra and bladder were anastomosed. The bladder flap was mobilized and sutured to the healthy urethra using 4‐0 PDS interrupted sutures. Follow‐up assessments included uroflowmetry, postvoid residual urine volume measurement (PVR), and questionnaires on daily pad use and patient satisfaction. Success was defined as cystourethroscope passage through the anastomosis without resistance and no need for additional procedures.ResultsThe median patient age was 69. All patients had a history of failed endoscopic treatments. The median follow‐up was 13 months, with all considered successful. The median postoperative maximum flow rate was 26.6 mL/s, and the median PVR was 12 mL. Postoperatively, two (40%) were pad‐free, and three (60%) used 1–2 pads daily. Three (60%) patients were ‘very satisfied,’ one (20%) ‘satisfied,’ while one (20%) was ‘dissatisfied.’ConclusionsY‐V‐plasty is an effective option for refractory BNS, improving urinary function and quality of life.
What Drives Design Education in Korean Classrooms? The History of South Korea's National Curriculum and Some Proposals for Design Education in Its Current Iteration
Authors: Choi Seolyung , Hyun Eunryung 
Published: January 2025

AbstractIn South Korea, the National Curriculum and textbooks, especially within design education, are closely intertwined. The Curriculum is critical in establishing educational goals and standards for each subject, acting as a blueprint for schooling. Textbooks, which must be approved, are designed to align with this Curriculum. This article introduces new content for design textbooks guided by the 2022 Curriculum revisions, highlighting the importance of using design to solve real‐world problems and the potential for interdisciplinary collaboration. Consequently, this article puts forth the following proposed content to be included in the forthcoming design textbook: recognising and appreciating exemplary design in everyday life, acquiring diverse knowledge to foster creative problem‐solving skills, and comprehending the significance of design for all individuals.
How Children Draw, Write and Tell About Portraying Mixed Emotions in Themselves and Others Children
Authors: Burkitt Esther , Watling Dawn 
Published: January 2025

AbstractChildren alter their drawings in multiple ways depending on whether they are drawing happy, sad or mixed happy and sad experiences. However, their explanations of why they may use features to show emotions may be overlooked in interpretation. The present study therefore used the Draw–Write–Tell paradigm which integrates children's explanations of feature use to explore children's drawn representations of mixed emotional experiences. 92 (42 boys, 50 girls) children between the ages of 6–8 years (6 years 4 months–7 years 11 months, M = 7 years 2 months, SD = 3 months) were recruited on the basis of age from mainstream schools across the South East and South West of the UK. Children were allocated to one of two conditions hearing either a vignette about themselves (n = 46, 22 girls) or another age and gender matched child (n = 47, 27 girls). Following a mixed emotion presence interview, all children competed the Draw–Write–Tell process. Eleven themes of how children explained how they drew mixed emotion experiences emerged following an exhaustive thematic analysis indicating individual, prosocial and cultural influences on their drawing choices. The importance of using this approach when interpreting children's drawings of emotional experiences is discussed.
Factors Associated With Mental Health Literacy, Depression, and Anxiety Amongst Indonesian Adolescents
Authors: Yani Desy Indra , Wong John Chee Meng , Pikkarainen Minna , Chua Joelle Yan Xin , Wong Hung Chew , Goh Yong Shian Shawn , Shorey Shefaly 
Published: January 2025

ABSTRACTAimsThis study aims to identify factors associated with mental health literacy (mental health knowledge and attitudes towards mental health and help‐seeking behaviours), depression and anxiety amongst adolescents, and test the hypothesised model by examining the interrelationships between these outcomes.DesignCross‐sectional descriptive quantitative research.MethodsUsing convenient sampling, 615 adolescents from four public schools completed online questionnaires measuring mental health literacy, depression, and anxiety. The data were analysed using Pearson correlation, multiple linear regression, and structural equation modelling (SEM).ResultsIndividual factors (e.g., gender, physical health and past traumatic experiences), family factors (e.g., parental criticism and family support) and school/community factors (e.g., academic pressure and safety) were associated with mental health outcomes. SEM revealed an association between higher mental health knowledge and better attitudes towards mental health and help‐seeking behaviours but did not show a significant association with depression and anxiety.ConclusionsFindings emphasise the need for holistic and culturally safe approaches to address adolescent mental health in Indonesia.ImplicationsFuture research should focus on developing and evaluating tailored mental health interventions in Indonesia that address individual, family, school, and community factors. These interventions should target the interrelated aspects of mental health literacy, depression, and anxiety identified in this study. Key areas for intervention include enhancing self‐esteem, promoting help‐seeking behaviours, supporting spirituality, managing long‐term conditions, improving sleep hygiene, encouraging physical activity, teaching stress management techniques, fostering diversity, managing trauma, and combating discrimination. A comprehensive approach to adolescent mental well‐being should integrate parental involvement, peer support systems, community engagement initiatives, and mental health literacy education.ImpactThis research informs future interventions such as school‐based programs, family‐oriented campaigns, and community initiatives to support adolescent mental health, potentially influencing policy decisions, and resource allocation in mental health services.Reporting MethodSTROBE guidelines.Patient or Public ContributionNo direct patient or public contribution.
Evaluating Intervention Reporting in Nursing Journal RCTs Using the TIDieR Checklist: A Cross‐Sectional Study
Authors: Cao Liujiao , Liu Wenhao , Yao Liang , He Wenbo , Yin Zhe , Li Ka , Tam Wilson 
Published: January 2025

ABSTRACTAimTo assess the completeness of intervention reporting in randomised controlled trials (RCTs) published in nursing journals based on the Template for Intervention Description and Replication (TIDieR) checklist.DesignA cross‐sectional study.MethodsRCTs published in English in nursing journals between January 2022 and December 2022 were identified through PubMed. Title‐ and abstract‐screening were undertaken independently by two reviewers to select eligible trials, from which data were extracted. Reports of interventions were likewise independently evaluated based on the TIDieR checklist. Binary logistic regression analysis was performed to investigate potential predictors for the compliance of TIDieR.ResultsOur analysis included 303 eligible trials, which generally adhered to most items on the TIDieR checklist, though adherence varied across the trials. Slightly fewer than half of the trials demonstrated good reporting quality. Poor reporting was associated in areas such as modifications, tailoring, and the type of locations where the intervention occurred. Additionally, suboptimal reporting on intervention adherence was noted. Compliance with TIDieR was found to be influenced by factors such as funding availability and the journal's ranking.ConclusionsOur study revealed suboptimal reporting of the TIDieR items in RCTs published in nursing journals. More rigorous adherence to the TIDieR checklist is needed to improve the quality of intervention reporting. Additionally, comparing adherence before and after the implementation of TIDieR may be considered in future investigations.ImpactThis paper represents the first study to appraise the reporting quality of RCTs in nursing journals based on the TIDieR checklist. Evidence of suboptimal compliance of RCTs to the TIDieR checklist items is presented.Patient or Public ContributionsNo patient or public contribution applied.
No Right to an Open Future
Authors: Millum Joseph 
Published: January 2025

ABSTRACTLiberals writing about the family frequently cite the child's ‘right to an open future’ in discussions of the ethics of parental decision‐making for young children. This purported right grounds certain claims on behalf of children in considerations related to their future autonomy. In this article, I argue that there is no compelling argument in favor of a distinctive ‘right to an open future’ construed as either a negative or a positive right. Insofar as claims made about the content of this purported right are justified, they can be grounded in the interests of the child or in other uncontroversial rights. Talk of a ‘right to an open future’ serves only to obscure the ethical considerations that actually matter and citing the right is not helpful in deciding what may or should be done. I illustrate this claim by reference to two examples of how the ‘right to an open future’ has been applied: one regarding genetic testing for adult‐onset disorders and one regarding selection for disabilities.
Effect of Visual Programming Instruction on Students' Flow Experience, Programming Self‐Efficacy, and Sustained Willingness to Learn
Authors: Huang Chiao Ling , Fu Lianzi , Hung Shih‐Chieh , Yang Shu Ching 
Published: January 2025

ABSTRACTBackgroundMany studies have highlighted the positive effects of visual programming instruction (VPI) on students' learning experiences, programming self‐efficacy and flow experience. However, there is a notable gap in the research on how these factors specifically impact programming achievement and learning intentions. Our study addresses this gap by focusing on flowchart‐based programming—a relatively underexplored area in educational research. To ensure relevance to the educational context, AbilixChart and Ability Storm SK902 were specifically selected for their alignment with the curriculum of the target school, where these tools are widely utilised in both teaching and extracurricular activities. This alignment allowed for a seamless integration of these tools into regular classroom practices after the study's conclusion, ensuring continued application and maximising the study's practical impact. Furthermore, integrating educational robots enhanced student engagement and provided a practical means to evaluate the accuracy of their programming skills. By doing so, our study not only contributes to filling a gap in the literature but also has the potential to influence educational practices by demonstrating the value of incorporating flowchart‐based programming and robotics into the curriculum.ObjectivesThe present study aims to conduct an instructional experiment utilising VPI with flowchart‐based programming tools. The main objective is to investigate how these tools influence 219 high school students' flow experience, programming self‐efficacy, and sustained learning willingness.MethodsThis study employed a pre‐ and post‐test design with a single group and conducted an 11‐week instructional experiment. The students used the Abilix Chart software and the Ability Storm SK902 kit to build an intelligent car and learn about visual programming. They were tasked with independently designing programs to solve practical problems in different scenarios. Research tools included Scales of Flow Experience, Computer Programming Self‐Efficacy, Sustained Learning Willingness and Program Achievement.ResultsThe findings revealed that VPI effectively improved students' programming achievement, flow experience and programming self‐efficacy. Students with programming learning experience surpassed their inexperienced peers in willingness to engage in sustained learning. Conversely, 4.57% of the group with lower pre‐test scores and no learning experience showed more positive emotional experience than those with learning experience.ConclusionsThe results indicated that VPI positively affected programming achievement, self‐efficacy and flow experience. Regardless of prior programming experience, all students benefited from VPI. Additionally, self‐efficacy and flow experience were key factors influencing sustained learning motivation and achievement.
Impact of Sodium‐Glucose Co‐Transporter 2 Inhibitors on Atrial Fibrillation Recurrence Post‐Catheter Ablation Among Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta‐Analysis
Authors: Abdelhadi Naser A. , Ragab Khaled Mohamed , Elkholy Mohammed , Koneru Jayanthi , Ellenbogen Kenneth A. , Pillai Ajay 
Published: January 2025

ABSTRACTAtrial fibrillation (AF) is the most common cause of arrhythmia‐induced cardiomyopathy. Effective management strategies include medical therapy for rate and rhythm control, catheter ablation (CA), and goal‐directed medical therapy. Sodium‐glucose co‐transporter 2 inhibitors (SGLT2i), a novel class of antidiabetic drugs, have shown a promising impact in reducing cardiovascular events in diabetic and nondiabetic heart failure (HF) patients. It is unclear what impact SGLT2i use may have on AF recurrence following CA. To evaluate the effects of SGLT2i on preventing AF recurrence following CA and its impact on other cardiovascular outcomes. We performed a comprehensive literature search through multiple search engines (PubMed, Scopus, Web of Science, and Cochrane) to include eligible studies using the appropriate keywords until 10 April 2024. Our search yielded nine eligible studies with 16 857 patients. Our analysis reveals a significant reduction in AF recurrence after CA among patients receiving SGLT2i compared to non‐SGLT2i medications (RR = 0.72, 95% CI [0.67–0.78], p < 0.00001). Additionally, SGLT2i therapy was associated with decreased all‐cause hospitalizations and reduced risk of ischemic stroke. However, no significant difference in all‐cause mortality was observed between SGLT2i and non‐SGLT2i groups. Our study found that SGLT2 inhibitors significantly reduced AF recurrence post‐CA in diabetic patients. Moreover, SGLT2i use was associated with lowered hospitalization and ischemic stroke risk. Though no significant difference in mortality was noted, the decrease in hospitalization suggests a possible favorable effect on cardiovascular events.
Characterization of NK Cells Using Single‐Cell RNA Sequencing in Patients With Acute‐On‐Chronic Liver Failure
Authors: Zhao Ninghui , Wang Han , Zhang Miaoxin , Tian Wei , Liu Yulong , Tian Dean , Yao Jia , Liu Mei 
Published: January 2025

ABSTRACTBackground and AimAcute‐on‐chronic liver failure (ACLF) is characterized by fast progression and high mortality, with systemic inflammation and immune paralysis as its key events. While natural killer (NK) cells are key innate immune cells, their unique function and subpopulation heterogeneity in ACLF have not been fully elucidated. This study aimed to investigate the characteristics of NK cell subsets in the peripheral blood of patients with ACLF and determine their roles in the inflammatory responses.MethodsCirculating NK cells (14 751 cells) from patients with ACLF and healthy controls (HCs) were subjected to single‐cell RNA sequencing (scRNA‐seq). Clustering and annotation were used to identify the features of NK cell subsets and the characteristics of disease progression in ACLF.ResultsFour NK cell subsets were obtained, including adaptive NK cells, mature NK cells, inflamed NK cells, and CD56bright NK cells. Compared with the HCs, the patients with ACLF had a significantly lower proportion of Mature NK cells and a higher proportion of Inflamed NK cells. Quasi‐temporal analysis showed that Inflamed NK cells were highly enriched in the late quasi‐temporal sequence, and genes related to pro‐inflammatory were significantly up‐regulated in Inflamed NK cells. In addition, scRNA‐seq and flow cytometry confirmed that the expression level of cell migration inducing hyaluronidase 2 (CEMIP2) in NK cells progressively increased from the HC group to the ACLF survival group and then to the ACLF death group.ConclusionsscRNA‐seq reveals that Inflamed NK cell subsets are associated with ACLF progression and poor prognosis. CEMIP2 may be a molecular marker for ACLF progression.