bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low‐dose aspirin can inhibit exosomal release induced by radiotherapy in breast cancer and attenuate its inhibitory effect on NK cell proliferation
Authors: Wang Li , Hu Zaoxiu , Chen Ceshi , Chen Ting , Yao Zhihong , Li Wenhui , Yang Zuozhang 
Published: July 2023

AbstractBackgroundBreast cancer (BC) seriously threatens women's health. Aspirin plays a key role in the treatment and prognosis of BC.ObjectiveTo explore the effect of low‐dose aspirin on BC radiotherapy through the mechanism of exosomes and natural killer (NK) cells.MethodsBC cells were injected into the left chest wall to establish a BC model in nude mice. Tumor morphology and size were observed. Immunohistochemical staining for Ki‐67 was used to observe the proliferation of tumor cells. TUNEL was used to detect the apoptosis of cancer cells. Protein levels of exosomal biogenesis‐ and secretion‐related genes (Rab 11, Rab27a, Rab27b, CD63, and Alix) were detected by Western blot. Flow cytometry was used to detect apoptosis. Transwell assays were used to detect cell migration. A clonogenic assay was used to detect cell proliferation. Exosomes of BT549 and 4T1‐Luc cells were extracted and observed by electron microscopy. After the coculture of exosomes and NK cells, the activity of NK cells was detected by CCK‐8.ResultsThe protein expression of genes related to exosomal genesis and secretion (Rab 11, Rab27a, Rab27b, CD63, and Alix) in BT549 and 4T1‐Luc cells was upregulated under radiotherapy treatment. Low doses of aspirin inhibited exosome release from BT549 and 4T1‐Luc cells and alleviated the inhibitory effect of BC cell exosomes on NK cell proliferation. In addition, knocking down Rab27a reduced the protein levels of exosome‐related and secretion‐related genes in BC cells, further enhancing the promotive effect of aspirin on NK cell proliferation, while overexpressing Rab27a had the opposite effect. Aspirin was combined at a radiotherapeutic dose of 10 Gy to enhance the radiotherapy sensitivity of radiotherapy‐tolerant BC cells (BT549R and 4T1‐LucR). Animal experiments have also verified that aspirin can promote the killing effect of radiotherapy on cancer cells and significantly inhibit tumor growth.ConclusionLow doses of aspirin can inhibit the release of BC exosomes induced by radiotherapy and weaken their inhibition of NK cell proliferation, promoting radiotherapy resistance.
Overexpression of CD73 is associated with recurrence and poor prognosis of gingivobuccal oral cancer as revealed by transcriptome and deep immune profiling of paired tumor and margin tissues
Authors: Chatterjee Ankita , Chaudhary Amrita , Ghosh Arnab , Arun Pattatheyil , Mukherjee Geetashree , Arun Indu , Maitra Arindam , Biswas Nidhan , Majumder Partha P. 
Published: July 2023

AbstractBackgroundFor various cancers, differences in response to treatment and subsequent survival period have been reported to be associated with variation in immune contextures.AimWe sought to identify whether such association exists in respect of gingivobuccal oral cancer.Materials and methodsWe performed deep immune profiling of tumor and margin tissues collected from 46 treatment naïve, Human Papillomavirus (HPV) negative, patients. Each patient was followed for 24 months and prognosis (recurrence/death) noted. Key findings were validated by comparing with TCGA‐HNSC cohort data.ResultsAbout 28% of patients showed poor post‐treatment prognosis. These patients exhibited a high probability of recurrence even within 1 year and death within 2 years. There was restricted immune cell infiltration in tumor, but not in margin, among these patients. Reduced expression of eight immune‐related genes (IRGs) (NT5E, THRA, RBP1, TLR4, ITGA6, BMPR1B, ITGAV, SSTR1) in tumor strongly predicted better quality of prognosis, both in our patient cohort and in TCGA‐HNSC cohort. Tumors of patients with better prognosis were associated with (a) lower CD73+ cells with concomitant lower expression level of NT5E/CD73, (b) higher proportions of CD4+ and CD8+ T cells, B cells, NK cells, M1 macrophages, (c) higher %Granzyme+ cells, (d) higher TCR and BCR repertoire diversities. CD73 expression in tumor was associated with low CD8+ and CD4+ T cells, low immune repertoire diversity, and advanced cancer stage.Discussion and conclusionHigh infiltration of anti‐tumor immune cells in both tumors and margins results in good prognosis, while in patients with minimal infiltration in tumors in spite of high infiltration in margins results in poor prognosis. Targeted CD73 immune‐checkpoint inhibition may improve clinical outcome.
Misuse of tumor marker levels leads to an insufficient International Germ Cell Consensus Classification (IGCCCG) risk group assignment and impaired treatment
Authors: Majewski Matthäus , Paffenholz Pia , Ruf Christian , Che Yue , Seidel Christoph , Heinzelbecker Julia , Schmelz Hans‐Ulrich , Matthies Cord , Albers Peter , Bokemeyer Carsten , Heidenreich Axel , Pichler Martin , Nestler Tim ,   the GTCSG (German Testicular Cancer Study Group)
Published: July 2023

AbstractBackgroundMetastatic germ cell tumors of the testis (GCTs) are risk‐stratified according to the International Germ Cell Cancer Collaborative Group (IGCCCG) classification system. This risk classification is based on anatomical risk factors as well as tumor marker levels of AFP, HCG, and LDH assessed pre‐chemotherapy after orchiectomy treatment. An incorrect classification is possible when pre‐orchiectomy marker levels are used, possibly resulting in over‐ or undertreatment of patients. The aim was to investigate the potential frequency and clinical relevance of incorrect risk stratification using pre‐orchiectomy tumor marker levels.MethodsA multicenter registry analysis, including patients with metastasized nonseminomatous GCT (NSGCT), was conducted by investigators of the German Testicular Cancer Study Group (GTCSG). Based on the marker levels at different timepoints, IGCCCG risk groups were calculated. The agreement was tested using Cohen's kappa.ResultsA total of 672 of 1910 (35%) patients were diagnosed with metastatic NSGCTs, and 523 (78%) had sufficient data for 224 follow‐up data points. By using pre‐orchiectomy tumor marker levels, 106 patients (20%) would have been incorrectly classified. Seventy‐two patients (14%) were classified into a higher risk category, and 34 patients (7%) were classified into a lower risk category. Cohen's kappa was 0.69 (p < 0.001), showing a strong agreement between the use of both marker timepoints. The treatment of misclassified patients would have resulted in an overtreatment of 72 patients or undertreatment of 34 patients.ConclusionsThe use of pre‐orchiectomy tumor marker levels may lead to an incorrect risk classification and might subsequently lead to under‐ or overtreatment of patients.
CHAN: Skeleton based action recognition by multi‐level feature learning
Authors: Lu Jian , Gong Yinghao , Zhou Yanran , Ma Chengxian , Huang Tingting 
Published: July 2023

AbstractSkeleton‐based action recognition has been continuously and intensively studied. However, dynamic 3D skeleton data are difficult to be popularized in practical applications due to the restricted data acquisition conditions. Although the action recognition method based on 2D pose information extracted from RGB video can effectively avoid the influence of complex background, it is susceptible to factors such as video jitter and joint overlap. To reduce the interference of the aforementioned factors, we use two‐dimensional skeletal joint coordinate modal information to represent the changes in human body posture. First, we use a target detector and pose estimation algorithm to obtain the joint coordinates of each frame sample from RGB video. Then the feature extraction network is combined to perform multi‐level feature learning to establish correspondence between actions and corresponding multi‐level features. Finally, the hierarchical attention mechanism is introduced to design the model named CHAN. By calculating the association between elements, the weight of the action classification is redistributed. Extensive experiments on three datasets demonstrate the effectiveness of our proposed method.
The Journal of Consumer Behaviour's first 20 years
Authors: Eastman Jacqueline K. , Muncy James A. , Jain Varsha , Iyer Rajesh 
Published: July 2023

AbstractWe analyzed and compared the Journal of Consumer Behaviour content in its first 20 years of publication. Articles were categorized into seven topics (Internal Factors, External Factors, Decision Process, Social Issues, Internet, Managerial Issues, and Research Methods) with subtopics. Authorship, citations based on Google Scholar, geographic representation of authors, and methodologies employed across the first 20 years were also explored. The results are discussed in terms of their implications for the journal and consumer behaviour. This analysis provides suggestions for future research to be published by the Journal of Consumer Behaviour.
CO‐WOA: Novel Optimization Approach for Deep Learning Classification of Fish Image
Authors: Aziz Rabia Musheer , Mahto Rajul , Das Aryan , Ahmed Saboor Uddin , Roy Priyanka , Mallik Saurav , Li Aimin 
Published: July 2023

AbstractThe most significant groupings of cold‐blooded creatures are the fish family. It is crucial to recognize and categorize the most significant species of fish since various species of seafood diseases and decay exhibit different symptoms. Systems based on enhanced deep learning can replace the area's currently cumbersome and sluggish traditional approaches. Although it seems straightforward, classifying fish images is a complex procedure. In addition, the scientific study of population distribution and geographic patterns is important for advancing the field's present advancements. The goal of the proposed work is to identify the best performing strategy using cutting‐edge computer vision, the Chaotic Oppositional Based Whale Optimization Algorithm (CO‐WOA), and data mining techniques. Performance comparisons with leading models, such as Convolutional Neural Networks (CNN) and VGG‐19, are made to confirm the applicability of the suggested method. The suggested feature extraction approach with Proposed Deep Learning Model was used in the research, yielding accuracy rates of 100 %. The performance was also compared to cutting‐edge image processing models with an accuracy of 98.48 %, 98.58 %, 99.04 %, 98.44 %, 99.18 % and 99.63 % such as Convolutional Neural Networks, ResNet150V2, DenseNet, Visual Geometry Group‐19, Inception V3, Xception. Using an empirical method leveraging artificial neural networks, the Proposed Deep Learning model was shown to be the best model.
Multifocal osteomyelitis in a child with sickle cell disease and review of the literature regarding best diagnostic approach
Authors: Scruggs Megan , Pateva Irina 
Published: July 2023

Key Clinical MessageIn patients with sickle cell disease, we must be more cognizant of the possibility of multifocal osteomyelitis. Diagnosis can be challenging in this patient population as the symptoms mimic vaso‐occlusive crisis. There is no gold standard in imaging.AbstractOsteomyelitis occurs more frequently in children with sickle cell disease. Diagnosis is challenging as it mimics vaso‐occlusive crises, a common manifestation of sickle cell disease. We present a case of a 22‐month‐old girl with sickle cell disease and multifocal osteomyelitis. We review the literature on the utility of diagnostic imaging.
Numerical Study on the Granular Flow and Heat Transfer of a Calcium Looping CO2 Capture System
Authors: Chou Shih-Hao , Chen Yi-Shun , Hsiau Shu-San , Liu Shang-Yu 
Published: July 2023

AbstractThe calcium looping process has become a promising technology for reducing carbon dioxide emissions because of its lower energy consumption compared with other methods. A three‐dimensional multifluid model based on the kinetic theory was employed to study the movement of granules in the calciner. The results demonstrated that an increase in the rotation speed and inclination angle of the calciner led to a decrease in the residence time of the particles. Simultaneously, the probability of the particles being heated was reduced. Insufficiently calcined particles reduce the carbon capture capacity in the next cycle; therefore, suitable operating conditions and mechanism designs are very important.
Efficacy and safety of oral immunotherapy for peanut, cow's milk, and hen's egg allergy: A systematic review of randomized controlled trials
Authors: Lodge Caroline J. , Waidyatillake Nilakshi , Peters Rachel L. , Netting Merryn , Dai Xin , Burgess John , Hornung Catherine J. , Perrett Kirsten P. , Tang Mimi L. K. , Koplin Jennifer J. , Dharmage Shyamali C. 
Published: July 2023

AbstractBackgroundOral immunotherapy (OIT) is a promising treatment for food allergies; however, safety is a concern. We synthesized evidence from the best randomized controlled trials (RCTs) on efficacy/safety of OIT for desensitization (DS) and remission (sustained unresponsiveness (SU)) in IgE mediated allergy to peanut, hen's eggs, and cow's milk.BodyWe searched Pubmed, EMBASE, and Cochrane databases (Until Oct 22) identifying 16 eligible RCTs published in English measuring food allergy by food challenge at the beginning and at the end of the study. The Cochrane Risk of Bias tool was used to assess study quality. We found 18 eligible studies. There was evidence of efficacy for DS for all allergens: peanut (RR 11.32; 95% CI 5.93, 21.60, I2 49%, 8 studies); hen's egg (RR 4.67; 2.66, 8.21, I2 0%, 5 studies); cow's milk (RR 13.98; 3.51, 55.65, I2 0%, 4 studies) and evidence for SU for peanut (RR 7.74; 2.90, 20.69, I2 0%, 3 studies) and hen's egg (RR 6.91; 1.67, 28.57, I2 0%, 2 studies). Allergic events were increased with intervention, and risk of adrenaline use increased for peanut RR 2.96; 1.63, 5.35, I2 0%, 8 studies; egg RR 1.71; 0.42, 6.92, I2 0%, 6 studies; and milk RR 8.45; 2.02, 35.27, I2 0%, 4 studies.ConclusionWe found strong evidence that peanut, hen's egg, and cow's milk OIT can induce DS and some evidence for remission. There was a high risk of allergic reactions. Generalizability to the entire food allergic population is not known.
Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma
Authors: Chen Qiurui , Wang Xuejia , Zheng Yichen , Ye Ting , Liu Jing , Wang Jin‐Quan , Zhang Wen‐feng , Wu Feng‐Lin , Bo Huaben , Shao Hongwei , Zhang Rongxin , Shen Han 
Published: July 2023

AbstractBackgroundChronic inflammation is considered the most critical predisposing factor of hepatocellular carcinoma (HCC), with inflammatory cell heterogeneity, hepatic fibrosis accumulation, and abnormal vascular proliferation as prominent features of the HCC tumor microenvironment (TME). Cancer‐associated fibroblasts (CAFs) play a key role in HCC TME remodeling. Therefore, the level of abundance of CAFs may significantly affect the prognosis and outcome in HCC patients.MethodsUnsupervised clustering was performed based on 39 genes related to CAFs in HCC identified by single‐cell RNA sequencing data. Patients of bulk RNA were grouped into CAF low abundance cluster and high abundance clusters. Subsequently, prognosis, immune infiltration landscape, metabolism, and treatment response between the two clusters were investigated and validated by immunohistochemistry.ResultsPatients in the CAF high cluster had a higher level of inflammatory cell infiltration, a more significant immunosuppressive microenvironment, and a significantly worse prognosis than those in the low cluster. At the metabolic level, the CAF high cluster had lower levels of aerobic oxidation and higher angiogenic scores. Drug treatment response prediction indicated that the CAF high cluster could have a better response to PD‐1 inhibitors and conventional chemotherapeutic agents for HCC such as anti‐angiogenic drugs, whereas CAF low cluster may be more sensitive to transarterial chemoembolization treatment.ConclusionsThis study not only revealed the TME characteristics of HCC with the difference in CAF abundance but also further confirmed that the combination therapy of PD‐1 inhibitors and anti‐angiogenic drugs may be more valuable for patients with high CAF abundance.
On the stabilizing effect of rotation in the 3d Euler equations
Authors: Guo Yan , Huang Chunyan , Pausader Benoit , Widmayer Klaus 
Published: July 2023

AbstractWhile it is well known that constant rotation induces linear dispersive effects in various fluid models, we study here its effect on long time nonlinear dynamics in the inviscid setting. More precisely, we investigate stability in the 3d rotating Euler equations in with a fixed speed of rotation. We show that for any , axisymmetric initial data of sufficiently small size ε lead to solutions that exist for a long time at least and disperse. This is a manifestation of the stabilizing effect of rotation, regardless of its speed. To achieve this we develop an anisotropic framework that naturally builds on the available symmetries. This allows for a precise quantification and control of the geometry of nonlinear interactions, while at the same time giving enough information to obtain dispersive decay via adapted linear dispersive estimates.
Coordination Chemistry of the Antimony(III) and Bismuth(III) Cations using Bis(α‐iminopyridine) as Ligand
Authors: Haldar Hritwik , Yildiz Cem. B. , Majumdar Moumita 
Published: July 2023

AbstractBis(alpha‐iminopyridine) L has been employed as the redox non‐innocent Schiff‐base ligand to coordinate with cationic antimony(III) and bismuth(III) centers. Mono‐ and di‐ cationic compounds: [LSbCl2][CF3SO3] 1, [LBiCl2][CF3SO3] 2, [LSbCl2]2[Sb2Cl8] 3, [LBiCl2]2[Bi2Cl8] 4, [LSbCl][CF3SO3]2 5, [LBiCl][CF3SO3]2 6 have been isolated and characterized using single crystal X‐ray crystallography in the solid‐state and solution‐state NMR studies. These compounds have been prepared from PnCl3 (Pn=Sb, Bi) and chloride abstracting agent such as Me3SiCF3SO3 or AgCF3SO3 in the presence of L. The Bi tri‐cationic species forms heteroleptic compound 7, being coordinated by two types of Schiff‐base donors L and L′. The latter has been in situ generated by the cleavage of one of the two imines present in L.
On the Tunability of Toxicity for Viologen‐Derivatives as Anolyte for Neutral Aqueous Organic Redox Flow Batteries
Authors: de la Parra Sandra , Tamayo‐Ramos Juan Antonio , Rubio‐Presa Rubén , Perez‐Antolin Daniel , Ruiz Virginia , Sanz Roberto , Rumbo Carlos , Ventosa Edgar 
Published: July 2023

AbstractViologen‐derivatives are the most widely used redox organic molecules for neutral pH negative electrolyte of redox flow batteries. However, the long‐established toxicity of the herbicide methyl‐viologen raises concern for deployment of viologen‐derivatives at large scale in flow batteries. Herein, we demonstrate the radically different cytotoxicity and toxicology of a series of viologen‐derivatives in in vitro assays using model organisms representative of human and environmental exposure, namely human lung carcinoma epithelial cell line (A549) and the yeast Saccharomyces cerevisiae. The results show that safe viologen derivatives can be molecularly engineered, representing a promising family of negolyte materials for neutral redox flow batteries.
Newly designed single‐stage dual leg DC‐DC/AC buck‐boost converter for grid connected solar system
Authors: Suresh Krishnan , Parimalasundar Ezhilvannan 
Published: July 2023

SummaryThis paper proposes a novel single‐stage buck‐boost inverter based on dual leg. Modulation techniques, working principle, guidelines for components design, and guidelines are discussed and presented. A theoretical concept is initially tested in Simulink platform and practically verified with a test bench model. A practical model is developed to verify the simulation model and tested different modes of operation are analyzed. The main advantages of the proposed work are as follows: The number of passive components is less, switching frequency components are not high so leakage current is very less, and voltage control in a wide range is achieved without using a DC link capacitor. High efficiency can be achieved due to multi‐stage operation. This proposed work is suitable for high/low voltage PV‐based energy conversion. Electromagnetic interference is also reduced due to continuous input current.
Simple experimental and analytical methods to estimate the power coupling efficiency in plasma discharges
Authors: Delacqua L. Colina , Ouaras K. , Redolfi M. , Orlac'H J.‐M. , Silva F. , Bonnin X. , Hassouni K. , Lombardi G. 
Published: July 2023

AbstractA simple experimental method to estimate the power effectively absorbed by a plasma is presented. It relies on a thermal management study that is applied to the whole discharge system, providing the energy released by the plasma and lost by convection and radiation at the reactor walls. The methodology is illustrated in the case of H2 Electron Cyclotron Resonance microwave plasma. Nevertheless, this method can be extended to a variety of electrical discharge or feed gases. Using this method, an experimental coupling efficiency of ∼22 ± ∼8% was derived. In comparison, an analytical balance of the plasma power absorption yields a theoretical coupling efficiency of ∼28 ± ∼9%.
Exosome‐mediated PROTACs delivery to target viral infections
Authors: Mukerjee Nobendu , Maitra Swastika , Ghosh Arabinda , Subramaniyan Vetriselvan , Sharma Rohit 
Published: July 2023

AbstractExosome‐based targeted delivery of Proteolysis‐Targeting Chimeras (PROTACs) is an innovative approach that provides a promising solution for addressing the complex issues of viral diseases. This strategy significantly mitigates the off‐target effects associated with traditional therapeutics by facilitating targeted delivery of PROTACs, which in turn enhances the overall therapeutic outcomes. Challenges like poor pharmacokinetics and unintended side effects, commonly observed with conventional PROTACs usage, are effectively managed with this approach. Emerging evidence affirms the potential of this delivery mechanism in curbing viral replication. However, it is crucial to undertake more comprehensive investigations for optimizing exosome‐based delivery systems and conducting stringent safety and efficacy assessments within preclinical and clinical settings. The advancements in this field could potentially redefine the therapeutic landscape for viral diseases, opening new vistas for their management and treatment.