bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between baseline dissociation levels and stress-induced state dissociation in patients with posttraumatic-stress disorder, borderline personality disorder, and major depressive disorder
Authors: Graumann Livia , Heekerens Johannes Bodo , Duesenberg Moritz , Metz Sophie , Spitzer Carsten , Otte Christian , Roepke Stefan , Wingenfeld Katja 
Published: March 2023

Abstract
Introduction
Dissociative symptoms are highly prevalent in patients with trauma-related disorders such as borderline personality disorder (BPD) and posttraumatic-stress disorder (PTSD), and also occur in patients with depressive disorders. Acute dissociative states are theorized to be stress-related, and some individuals experience recurring patterns of dissociation. The relationship between the intensity of dissociative episodes (trait-like dissociation) and acute dissociative states, however, is incompletely understood. In the present study, we investigated how levels of baseline (trait-like) dissociation relate to changes in dissociative states during a laboratory stress induction.

Methods
Our female sample comprised 65 patients with BPD and/or PTSD, 84 patients with major depressive disorder (MDD) and 44 non-clinical controls (NCC). Baseline dissociation was assessed at the start of the study using the Dissociation Tension Scale past week version (DSS-7). All participants underwent the Trier Social Stress Test (TSST) and a placebo version (P-TSST). Before and after the TSST or P-TSST, state dissociation was assessed using the Dissociation Tension Scale acute (DSS-4). We used structural equation models to estimate changes in state dissociation items (somatoform dissociation, derealization, depersonalization, analgesia), and to test whether these changes relate to levels of baseline dissociation.

Results
We found significant increases in all state dissociation items in response to the TSST in patients with BPD and/or PTSD and patients with MDD, but not in NCCs. Increases in somatoform dissociation and derealization during the TSST were significantly related to higher levels of baseline dissociation in patients with BPD and/or PTSD, but not in patients with MDD or NCCs. Results indicate no significant changes in state dissociation during the P-TSST.

Conclusion
Our results replicate earlier findings that patients with BPD and/or PTSD report higher levels of stress-related state dissociation than NCC and extend them to patients with MDD. In addition, our findings indicate that baseline levels of dissociation relate to stress-induced changes in state dissociation among patients with BPD and PTSD, but not patients with MDD. In clinical applications, measures of baseline dissociation could be used to facilitate the prediction and treatment of stress-related dissociative states in patients with BPD and/or PTSD.
Online comic-based art workshops as an innovative patient and public involvement and engagement approach for people with chronic breathlessness
Authors: Harrison Samantha L. , Lawrence Julian , Suri Sophie , Rapley Tim , Loughran Kirsti , Edwards James , Roberts Louise , Martin Denis , Lally Joanne E. 
Published: March 2023

Abstract
Background
Talking about breathlessness can be emotionally challenging. People can feel a sense of illegitimacy and discomfort in some research contexts. Comic-based illustration (cartooning) offers an opportunity to communicate in a more creative and inclusive way. We used cartooning in patient and public involvement and engagement (PPIE) work to explore symptoms of breathlessness and their impact on peoples’ everyday lives.

Main body
Five, 90-min cartooning workshops were delivered online to members of Breathe Easy Darlington (UK). The workshop series involved 5–10 Breathe Easy members and were facilitated by a professional cartoonist supported by three researchers. The experience of living with breathlessness was represented via illustrations of cartoon characters and ideas explored in subsequent conversations. Cartooning was fun and the majority found it a nostalgic experience. Sharing the experience helped the research team develop new understandings of breathlessness and fostered relationships with the Breathe Easy members. The illustrations showed characters leaning against objects, sweating and sitting down, demonstrating living with the sensation of not being in control.

Conclusion
Comic-based art, as a fun and innovative PPIE approach. It facilitated the research team becoming embedded in an existing group who will act as PPIE members on a long-term research programme. Illustrations enabled storytelling and fostered novel insights into the lived experiences of people with breathlessness including sensations of a loss of control, disorientation, and unsteadiness. This will impact on work investigating balance in people with chronic obstructive pulmonary disease. This model has potential to be applied in a range of PPIE and research contexts.
A review article of inflammatory bowel disease treatment and pharmacogenomics
Authors: Eltantawy Nashwa , El-Zayyadi Islam Abd El-Hamid , Elberry Ahmed A. , Salah Layla M. , Abdelrahim Mohamed E. A. , Kassem Amira B. 
Published: March 2023

AbstractInflammatory bowel disease (IBD) involves a variety of conditions, particularly Crohn’s disease (CD) and ulcerative colitis (UC). IBD is characterized by chronic inflammatory process of patient’s gut. This review aims to summarize the pharmacogenetics of biologics approved for IBD and the correlation with azathioprine-metabolizing enzymes and adverse reactions, therefore highlighting a likely relationship between particular polymorphisms and therapeutic response. Therefore, we reviewed and discussed the activities of TDM protocols which use monoclonal antibodies (mABs) with a particular attention on the integration of other actions aimed to exploit the most effective and safest medications for IBD cases. The pharmacotherapy of IBD (CD and UC) has experienced a great advancement with the advent of mABs which have peculiar pharmacokinetic properties differentiating them from chemical agents, like aminosalicylates, antimetabolites (e.g., azathioprine (AZA), 6-mercaptopurine (6MP)), and methotrexate), and immunosuppressant agents (steroids and cyclosporine). But clinical studies showed that biologicals might have pharmacokinetic variability which can affect the anticipated clinical outcomes, beyond primary resistance phenomena. Thus, therapeutic drug monitoring (TDM) protocols are applied to the doses of medications according to the required serum mABs levels. This aims to maximize the favorable effects of mABs and minimizing the toxicity. But, the presence of particular genetic polymorphisms in patients might determine a different outcome in response to treatment, indicating the heterogeneity of the effectiveness among IBD cases. Indeed, many reports demonstrated significant associations between polymorphisms and response to biologics. In conclusion, the improvement of TNF-, TNFR and IL-1 pharmacogenetics could be the best approach toward a targeted treatment for IBD. Pre-therapy genotyping has to be integrated with IBD therapeutic guidelines, as it is the most suitable approach to choose the most appropriate biologicals for each case. Also, the addition of pharmacodynamic markers (including serum, cellular, or tissue concentrations of TNF-alpha and IL-8) might boost the predictive performance of models and, eventually, control the disease with a significant improvement in quality of life (QOL).
Fluorescence strip sensor for sensitive determination of prometryn in foods
Authors: Gu Weifang , Suryoprabowo Steven , Guo Lingling , Wu Aihong , Liu Liqiang , Xu Chuanlai 
Published: March 2023

AbstractWe report the development of a sensitive, fast, and simple method for the detection of prometryn (PRO) in potato and celery using a lateral flow immunochromatographic assay (LFIA). A monoclonal antibody (mAb) against PRO was prepared under optimized conditions, and the 50% inhibition concentration (IC50) for use in ELISA was determined to be 0.6 ng mL−1. Moreover, the cut-off value for use in an LFIA was 50 ng mL−1. To validate the reliability of the developed LFIA strip, real samples were used, and the recovery rate was found to be 99.3–104.3%. The assays were completed within 8 min, demonstrating the suitability of our developed methods for the detection of PRO in potato and celery.
Current status and trends of antimicrobial resistance among clinical isolates in China: a retrospective study of CHINET from 2018 to 2022
Authors: Yang Weiwei , Ding Li , Han Renru , Yin Dandan , Wu Shi , Yang Yang , Zhu Demei , Guo Yan , Hu Fupin ,   on behalf of the China Antimicrobial Surveillance Network (CHINET) Study Group, Xu Yingchun , Zhang Xiaojiang , Zhang Zhaoxia , Ji Ping , Kang Mei , He Chao , Wang Chuanqing , Fu Pan , Xu Yuanhong , Huang Ying , Chen Zhongju , Sun Ziyong , Ni Yuxing , Sun Jingyong , Chu Yunzhuo , Tian Sufei , Hu Zhidong , Li Jin , Yu Yunsong , Lin Jie , Shan Bin , Du Yan , Guo Sufang , Wang Yanyan , Wei Lianhua , Wang Xin , Zhang Hong , Wang Chun , Hu Yunjian , Ai Xiaoman , Zhuo Chao , Su Danhong , Wang Ruizhong , Fang Hua , Yu Bixia , Gong Ping , Song Miao , Guo Dawen , Zhao Jinying , Liu Wen’en , Li Yanming , Jin Yan , Wang Yueling , Weng Kaizhen , Zhang Yirong , Xu Xuesong , Yan Chao , Huang Xiangning , Yu Hua , Li Yi , Wang Shanmei , Zhang Lixia , Ma Juan , Zhou Shuping , Ke Jiangwei , Zhu Lei , Meng Jinhua , Shen Han , Zhou Wanqing , Li Gang , Jia Wei , Wu Jinsong , Lu Yuemei , Li Jihong , Liu Jiangshan , Liao Longfeng , Gu Hongqin , Jiang Lin , He Wen , Xue Shunhong , Feng Jiao , Dou Rui , Yue Chunlei , Guo Ruyi , Jin Yan , Ma Xiaobo , Zheng Yanping , Hu Fangfang , Chen Yunsheng , Meng Qing , Xia Yun , Sun Shan 
Published: March 2023

AbstractAntimicrobial resistance (AMR) is a pressing issue in China, with antibiotic therapy becoming less effective against bacterial infections. To address this challenge, the China Antimicrobial Surveillance Network (CHINET) was established in 2005 to monitor antimicrobial resistance in the country. This study analyzed the CHINET data from teaching hospitals and evaluated the trends of AMR in China from 2018 to 2022. A range of 163,636 to 301,917 isolates was obtained per year, with the majority being Gram-negative bacilli (69.0% to 71.8%). The proportion of important multidrug-resistant pathogens remained stable over the years. While the analysis showed diverse AMR profiles for different bacterial species. Over the five years, generally decreased resistance rates were observed from the majority of the tested species. For example, resistance to ceftriaxone decreased in Escherichia coli and Klebsiella pneumoniae, while resistance to imipenem and meropenem decreased in Pseudomonas aeruginosa. Moreover, resistance to methicillin, gentamicin, fosfomycin, and clindamycin also decreased in clinical Staphylococcus aureus isolates. On the other hand, resistance levels of Acinetobacter baumannii remained stable. Our study provides a comprehensive overview of the AMR profiles of common bacterial species in China and highlights the ongoing efforts to address this challenge.
Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-Münster Study Group
Authors: van Weelderen Romy E. , Klein Kim , Harrison Christine J. , Jiang Yilin , Abrahamsson Jonas , Arad-Cohen Nira , Bart-Delabesse Emmanuelle , Buldini Barbara , De Moerloose Barbara , Dworzak Michael N. , Elitzur Sarah , Fernández Navarro José M. , Gerbing Robert B. , Goemans Bianca F. , de Groot-Kruseman Hester A. , Guest Erin , Ha Shau-Yin , Hasle Henrik , Kelaidi Charikleia , Lapillonne Hélène , Leverger Guy , Locatelli Franco , Masetti Riccardo , Miyamura Takako , Norén-Nyström Ulrika , Polychronopoulou Sophia , Rasche Mareike , Rubnitz Jeffrey E. , Stary Jan , Tierens Anne , Tomizawa Daisuke , Zwaan C. Michel , Kaspers Gertjan J.L. 
Published: March 2023

PURPOSE A previous study by the International Berlin-Frankfurt-Münster Study Group (I-BFM-SG) on childhood KMT2A-rearranged ( KMT2A-r) AML demonstrated the prognostic value of the fusion partner. This I-BFM-SG study investigated the value of flow cytometry-based measurable residual disease (flow-MRD) and evaluated the benefit of allogeneic stem-cell transplantation (allo-SCT) in first complete remission (CR1) in this disease. METHODS A total of 1,130 children with KMT2A-r AML, diagnosed between January 2005 and December 2016, were assigned to high-risk (n = 402; 35.6%) or non–high-risk (n = 728; 64.4%) fusion partner-based groups. Flow-MRD levels at both end of induction 1 (EOI1) and 2 (EOI2) were available for 456 patients and were considered negative (<0.1%) or positive (≥0.1%). End points were 5-year event-free survival (EFS), cumulative incidence of relapse (CIR), and overall survival (OS). RESULTS The high-risk group had inferior EFS (30.3% high risk v 54.0% non-high risk; P < .0001), CIR (59.7% v 35.2%; P < .0001), and OS (49.2% v 70.5%; P < .0001). EOI2 MRD negativity was associated with superior EFS (n = 413; 47.6% MRD negativity v n = 43; 16.3% MRD positivity; P < .0001) and OS (n = 413; 66.0% v n = 43; 27.9%; P < .0001), and showed a trend toward lower CIR (n = 392; 46.1% v n = 26; 65.4%; P = .016). Similar results were obtained for patients with EOI2 MRD negativity within both risk groups, except that within the non–high-risk group, CIR was comparable with that of patients with EOI2 MRD positivity. Allo-SCT in CR1 only reduced CIR (hazard ratio, 0.5 [95% CI, 0.4 to 0.8]; P = .00096) within the high-risk group but did not improve OS. In multivariable analyses, EOI2 MRD positivity and high-risk group were independently associated with inferior EFS, CIR, and OS. CONCLUSION EOI2 flow-MRD is an independent prognostic factor and should be included as risk stratification factor in childhood KMT2A-r AML. Treatment approaches other than allo-SCT in CR1 are needed to improve prognosis.
PD-1/PD-L1 Inhibitor Plus Chemotherapy Versus PD-1/PD-L1 Inhibitor in Microsatellite Instability Gastrointestinal Cancers: A Multicenter Retrospective Study
Authors: Chen Mifen , Wang Zhenghang , Liu Zimin , Deng Ting , Wang Xiaodong , Chang Zhiwei , Zhang Qi , Yang Wenlei , Liu Ning , Ji Zhi , Zhang Xiaotian , Wang Xicheng , Peng Zhi , Li Yi , Cao Yujuan , Jin Xuan , Lu Hongxia , Qu Huajun , Tang Yong , Xu Chunlei , Fang Weijia , Zhang Hangyu , Yan Dong , Wang Li , Li Jiayi , Zhang Jingdong , Wang Qiwei , Xue Liying , Yin Fei , Han Guangjie , Cheng Zhiqiang , Liu Qing , Jin Yongdong , Zhang Yinjie , Li Lanxing , Cao Baoshan , Yao Yanhong , Chen Zhiyu , Zou Jianling , Ying Jieer , Wei Qing , Tian Tiantian , Zhao Weifeng , Li Longmei , Zhang Tong , Song Fanghua , Ba Ya-er , Li Na , Gao Hui , Ji Yinghua , Bao Liying , Zhao Xiaochen , Cai Jinping , Yuan Zheping , Shen Lin , Li Jian 
Published: March 2023

PURPOSE To investigate the efficacy of PD-1/PD-L1 inhibitors plus chemotherapy versus anti–PD-1/PD-L1 monotherapy in advanced microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers. METHODS We retrospectively recruited patients with MSI/dMMR gastrointestinal cancer who received anti–PD-1/PD-L1 with or without chemotherapy and compared objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) of PD-1/PD-L1 inhibitor plus chemotherapy (chemo-anti–PD-1/PD-L1 group) and PD-1/PD-L1 inhibitor alone (anti–PD-1/PD-L1 group). Propensity score–based overlap weighting analysis was conducted to adjust the baseline covariable imbalance. Sensitivity analysis was performed to confirm the stability of the results by propensity score matching and multivariable Cox and logistic regression models. RESULTS A total of 256 patients were eligible, with 68 and 188 receiving chemo-anti–PD-1/PD-L1 and anti–PD-1/PD-L1, respectively. The chemo-anti–PD-1/PD-L1 group showed significant improvements versus the anti–PD-1/PD-L1 group in ORR (61.8% v 38.8%; P = .001), DCR (92.6% v 74.5%; P = .002), PFS (median PFS [mPFS], not reached [NR] v 27.9 months; P = .004), and OS (median OS [mOS], NR v NR; P = .014). After overlap weighting, the improvements tended to be more significant with chemo-anti–PD-1/PD-L1 versus anti–PD-1/PD-L1 in ORR (62.5% v. 38.3%; P < .001), DCR (93.8% v 74.2%; P < .001), PFS (mPFS, NR v 26.0 months; P = .004), and OS (mOS, NR v NR; P = .010). These results were solidified through sensitivity analysis. CONCLUSION Chemo-anti–PD-1/PD-L1 is superior to anti–PD-1/PD-L1 in MSI/dMMR gastrointestinal cancers with improved efficacy.
Extinction Panic: C. S. Lewis and Planetary Nihilism
Authors: Harper Tyler Austin 
Published: March 2023

AbstractToday figures like Elon Musk and Jeff Bezos have become high-profile evangelists for private space exploration, arguing that interplanetary colonization is necessary to save humanity from extinction. Although they may have the sheen of innovation, however, these ideas are not new. A century ago a coterie of British novelists, scientists, and social theorists writing during the interwar period became preoccupied with the possibility of human extinction and believed that such a fate might be avoided by taking human civilization to the stars. Watching these intellectual developments with a wary eye, a young C. S. Lewis was increasingly skeptical of both the “extinction panic” that gripped his contemporaries and the utilitarian and environmentally exploitative imagination of planetary conquest they championed. In response Lewis penned Out of the Silent Planet (1938), a novel that imagines three sentient species that have the means to prevent their own extinction but choose not to do so. Reading Lewis’s novel as a critique of the rapacious ideologies that defined this strain of interwar speculation, this article suggests that the novel models how the humanities might effectively respond to the extinction panic and cosmic adventurism that grip our own imperiled twenty-first century.
Black Soil
Authors: Bain Kimberly 
Published: March 2023

AbstractThis article turns to the minor Black matter of soil to map a provisional theory of Black alchemy. Black alchemy names an erotic and ethical orientation toward the Dead and dead matter. Sifting the metonymic, metaphysical, and material properties between (Black fleshly) matter and (earthly) matters, the article argues for an attention to the erotic relations among Blackness, soil, and Dead (matter). These relations disrupt and refuse the circuits of racial capitalism that establish both Black bodies and soil as sites of resource depletion and commodification. Turning to the syncretic knowledge system of Obeah and tinctures of grave dirt, cachexia africana and histories of dirt eating, and the 2019 performance and installation Dirt Eater by Kiyan Williams, the article asks, What are the practices of those who have collectively lived the end of the world and therefore are already dreaming the messy, dirty end of this one?
Urinary tract infection in an older patient: a case study and review
Authors: Read Haley , Mortimore Gerri 
Published: March 2023

This article will discuss and reflect on a case study involving the prescribing of nitrofurantoin, by a non-medical prescriber, for a suspected symptomatic uncomplicated urinary tract infection in a patient living in a care home. The focus will be around the consultation and decision-making process of prescribing and the difficulties faced when dealing with frail, uncommunicative patients. This article will explore and critique the evidence-base, local and national guidelines, and primary research around the pharmacokinetics and pharmacodynamics of nitrofurantoin, a commonly prescribed medication. Consideration of the legal, ethical and professional issues when prescribing in a non-medical capacity will also be sought, concluding with a review of the continuing professional development required to influence future prescribing decisions relating to the case study. Urinary tract infections are common in older people. Haley Read and Gerri Mortimore describe the decision making process in the case of an older patient with a UTI
Quantencomputing als Basistechnologie für den nächsten Konjunkturzyklus
Authors: Fasnacht Daniel , Straube Christian 
Published: March 2023

ZusammenfassungFür den nächsten Konjunkturzyklus benötigen wir viel mehr Rechenkapazität und Computer mit Transistortechnologie kommen an ihre Grenzen. Es sind also neue Innovationen gefragt. Der Quantencomputer, der das binäre System aushebelt und nicht auf Mikroprozessoren aus Silizium basiert, könnte eine Lösung sein. Diese Technologie wird sich exponentiell weiter entwickeln und nachhaltige Auswirkungen auf Wissenschaft, Wirtschaft und Gesellschaft haben. Speziell die Quantenkommunikation bietet eine vollständig neuartige Möglichkeit verteilter Rechenleistung, indem sie erlaubt Quantencomputer über Quantenkanäle zu vernetzen und so intrinsisch sichere Kommunikation zu gewährleisten. Dieser Artikel macht begreiflich, wie Quantencomputer neue Phänomene ausnutzen, die in der klassischen Physik nicht auftreten. Entlang vier identifizierter Haupteinsatzgebiete (Optimierung, Simulation, Maschinelles Lernen und Kryptographie) beschreiben wir Anwendungsmöglichkeiten in verschiedenen Branchen. Wir erklären wie technische Herausforderungen das Potenzial noch zurückhalten und wie der Quantencomputer als Ergänzung zu traditionellen Computersystemen einen großen Beitrag leisten kann. Entsprechend müssen Unternehmen nicht unbedingt in Quantencomputer investieren, sondern in deren Nutzung. Quantum als Service kann ein erster Schritt für visionäre Unternehmer sein, um sich damit vertraut zu machen und frühzeitig Wettbewerbsvorteile zu erlangen.
Dear Pandemic: A topic modeling analysis of COVID-19 information needs among readers of an online science communication campaign
Authors: Golos Aleksandra M. , Guntuku Sharath Chandra , Piltch-Loeb Rachael , Leininger Lindsey J. , Simanek Amanda M. , Kumar Aparna , Albrecht Sandra S. , Dowd Jennifer Beam , Jones Malia , Buttenheim Alison M. 
Published: March 2023

Background
The COVID-19 pandemic was accompanied by an “infodemic”–an overwhelming excess of accurate, inaccurate, and uncertain information. The social media-based science communication campaign Dear Pandemic was established to address the COVID-19 infodemic, in part by soliciting submissions from readers to an online question box. Our study characterized the information needs of Dear Pandemic’s readers by identifying themes and longitudinal trends among question box submissions.

Methods
We conducted a retrospective analysis of questions submitted from August 24, 2020, to August 24, 2021. We used Latent Dirichlet Allocation topic modeling to identify 25 topics among the submissions, then used thematic analysis to interpret the topics based on their top words and submissions. We used t-Distributed Stochastic Neighbor Embedding to visualize the relationship between topics, and we used generalized additive models to describe trends in topic prevalence over time.

Results
We analyzed 3839 submissions, 90% from United States-based readers. We classified the 25 topics into 6 overarching themes: ‘Scientific and Medical Basis of COVID-19,’ ‘COVID-19 Vaccine,’ ‘COVID-19 Mitigation Strategies,’ ‘Society and Institutions,’ ‘Family and Personal Relationships,’ and ‘Navigating the COVID-19 Infodemic.’ Trends in topics about viral variants, vaccination, COVID-19 mitigation strategies, and children aligned with the news cycle and reflected the anticipation of future events. Over time, vaccine-related submissions became increasingly related to those surrounding social interaction.

Conclusions
Question box submissions represented distinct themes that varied in prominence over time. Dear Pandemic’s readers sought information that would not only clarify novel scientific concepts, but would also be timely and practical to their personal lives. Our question box format and topic modeling approach offers science communicators a robust methodology for tracking, understanding, and responding to the information needs of online audiences.