bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between cardiovascular-kidney-metabolic syndrome and disability in activities of daily living: a nationwide longitudinal study among the middle-aged and older adults in China
Authors: Zhang Junfeng , Huang Huijie , Lin Zhan , Dong Jingran , Zhang Xiaoyan , Gao Jing , Liu Yin , Li Changping , Cui Zhuang 
Published: January 2025

BackgroundActivities in daily living (ADLs) disability triggered by aging population and chronic diseases in the middle-aged and older adults has become a major public health challenge. Cardiovascular-kidney-metabolic (CKM) syndrome, as a combination of several chronic conditions, has not yet been studied to explore its association with ADLs disability. We examined the association between CKM syndrome and ADLs disability among middle-aged and older adults in China and whether it varied by age and socioeconomic status.MethodsParticipants were from China Health and Retirement Longitudinal Study (CHARLS), which conducted four waves of surveys from 2011 to 2018. CKM stage was calculated through disease and physical examination data from CHARLS database. Meanwhile, the degree of disability was assessed through the ADL scale. Generalized linear mixed model was used to perform multivariate analysis to explore the association between CKM syndrome and the risk of ADLs disability.ResultsThe proportion of CKM stage 0, 1, 2, and 3 among the 5,898 eligible participants (median age 60 years, 60.27% women) in 2011 were 14.70, 30.23, 41.39, and 13.68%. The risk of ADL disability was increased by 16% (odds ratio [95% confidence interval]; 1.16 [1.00–1.33]) and 33% (1.33 [1.12–1.58]) in CKM stages 2 and 3 compared with stage 0. In addition, there was a greater risk of BADL disability in 75+ age group compared to other age groups, but no significant association with IADL disability. In the subgroup aged 75+, the risk of BADL disability was increased for CKM stage 2/3 (1.48 [1.01–2.18]/1.67 [1.06–2.64]) compared with stage 0. Only in the lowest quartile of socioeconomic status group CKM stage rise was strongly associated with the risk of disability. The risk of ADL disability was greater for CKM stage 2/3 (1.45 [1.15–1.83]/1.48 [1.11–1.98]) compared to CKM stage 0 in the lowest economic status quartile.ConclusionFor middle-aged and older adults in China, CKM syndrome is a key risk factor for ADLs disability. Therefore, effective measures should be taken to manage CKM stage at the lowest possible level, especially in older and economically disadvantaged populations.
Constructing a model of the factors related to the job wellbeing of preschool teachers in China: a grounded theory study
Authors: Nong Li-Ying , Liao Chen , Ye Jian-Hong 
Published: January 2025

IntroductionAs educational management research evolves, leadership styles are increasingly recognized as crucial managerial skills. Among various leadership approaches, empowering leadership has been found to significantly enhance employee job performance and satisfaction. However, there is limited research exploring the relationship between empowering leadership and the job wellbeing of preschool teachers in the educational sector.MethodsThis study examines the relationship between empowering leadership and preschool teachers' job wellbeing using the Job Demands-Resources (JD-R) model. Semi-structured interviews were conducted with 12 preschool teachers and 12 kindergarten leaders in China. The qualitative data collected were analyzed using grounded theory to identify themes and construct a systematic model.ResultsThe findings suggest that empowering leadership of kindergarten principals is positively related to preschool teachers' job wellbeing. This relationship is mediated through stress pathways, such as work pressure and burnout, as well as through enhanced organizational support and a positive work environment. Furthermore, empowering leadership influences teachers' personal motivation and work engagement, which in turn impacts their job wellbeing.DiscussionThe study highlights the importance of empowering leadership in improving preschool teachers' wellbeing. By addressing stress factors, enhancing organizational support, and promoting personal motivation, empowering leadership can foster a more supportive and engaging work environment. These findings have practical implications for leadership practices in early childhood education settings.
The health effect of relaxing entry regulation for private hospitals and its nonlinear characteristics: evidence from China
Authors: Jia Wanwen 
Published: January 2025

IntroductionRelaxing entry regulation for private hospitals and fostering competition in the healthcare market are crucial prerequisites for addressing the diverse healthcare demands of the population and promoting the development of a Healthy China. This study aims to comprehensively evaluate the health effect of relaxing entry regulation for private hospitals and to examine its nonlinear characteristics.MethodsUsing panel data from 31 provinces in mainland China, this study employs a fixed effects panel data model to investigate the health effect of relaxing entry regulation for private hospitals. To examine the potential nonlinear relationship, a panel threshold model is also employed. This study also employs a dynamic panel model as the econometric method to perform regression analysis for robustness testing.ResultsThe empirical findings indicate that relaxing entry regulation for private hospitals significantly improves the residents’ health level. This conclusion remains robust when different explanatory variables, measurement models and modified samples are applied. The heterogeneity analysis reveals that the health benefits of private hospital market entry are more pronounced in Central-Western region, regions with high medical resource endowment, and regions with High-quality competition. Furthermore, the health effect of relaxing entry regulation for private hospitals exhibits nonlinear characteristics: it weakens as economic development level reaches a certain threshold and becomes more pronounced as educational attainment reaches a specific threshold.DiscussionBased on these empirical results, Chinese provinces can be classified into three distinct types to guide the development of differentiated policies tailored to local conditions. This study provides valuable theoretical insights into promoting a fair competition mechanism in the healthcare market, enhancing the quality of private hospitals, and improving the overall health level of residents in China and other developing countries facing similar challenges.
Integrated omics profiling of individual variations in intestinal damage to the soybean allergen in piglets
Authors: Mi Mengmeng , Zheng Yaqing , Fu Xin , Bao Nan , Pan Li , Qin Guixin , Zhao Yuan 
Published: January 2025

IntroductionA small number of soybean allergens [including Glycinin (11S) and β-Conglycinin (7S)] in the commercially available corn-soybean meal diet can still cause allergy in some weaned piglets, which may be the result of the interaction of genetic, and nutrition, but the specific mechanism is still unclear.MethodsIn this study, 20 allergic piglets and 20 non-allergic piglets were selected from 92 weaned piglets by skin sensitization tests, which were used to examine the whole sequence genome. The indicators related to humoral and cellular immunity, transcriptomics, and metabolomics analysis were determined by randomly selecting 5 boars in the allergic group and non-allergic group and then performing a validation in vitro.ResultsThe sensitization rate of soybean antigen in the corn-soybean meal diet was 21.74% and there was a gender difference with the sensitization rate of female pigs (31.34%) being higher than that of male pigs (13.23%). Moreover, the levels of inflammatory factors (IL-1β, IL-4, TNF-α) and antibodies (IgG, IgE, and specific IgG) in allergic piglets were significantly higher than those in non-allergic piglets (P &lt; 0.05). Whole genome re-sequencing analysis revealed specific mutations in the exons and URT5 of TRAPPC2, PIR, CFP, and SOWAHD genes and showed significantly higher expression levels of related genes in the spleen of allergic piglets (P &lt; 0.05). Transcriptome analysis identified IL17REL, CCL19, CD1E, CD1.1, etc. immune differential genes, metabolomics results showed that soybean antigen affected the utilization and metabolism of intestinal nutrients in piglets, mainly the digestion and absorption of protein and the synthesis and metabolism of amino acids. Transfection of CFP/TRAPPC2/CCL19 siRNA could partially alleviate the injury of RAW264.7 cells or IPEC-J2 cells induced by β-Conglycinin.ConclusionTherefore, the individual differences in intestinal damage induced by soybean antigen protein in the corn-soybean meal diet are closely related to PIR, CFP, TRAPPC2, SOWAHD, and CCL19 genes. Soybean antigens affect the intestinal nutrient utilization and metabolism of piglets, which provides a scientific reference for the study of soybean antigen sensitization mechanisms, precision nutrition, disease prevention, and control of piglets, and also lays a foundation for human foodborne diseases.
Development and evaluation of optimized PCR and indirect ELISA for the detection of Morganella morganii in dairy cows
Authors: Zhang Meihua , Li Jiayi , Xue Jianfeng , Xu Huiling , Li Muzi , Xia Yibo , Qi Changxi , Zhang Pu , Liu Yongxia , Liu Jianzhu 
Published: January 2025

IntroductionMorganella morganii (M. morganii) is a Gram-negative opportunistic pathogen, whose increasing virulence and antibiotic resistance negatively impact dairy cow health and productivity, raising concerns in livestock health management. To mitigate this risk, rapid and reliable diagnostic methods for detection are essential. Currently, detection methods for M. morganii are underdeveloped, prompting us to develop both pathogenic and serological detection methods, including an optimized PCR technique and an indirect enzyme-linked immunosorbent assay (I-ELISA).MethodsThe optimized PCR method utilized bacterial suspensions directly as templates, bypassing the need for DNA extraction and thereby allowing the direct detection of M. morganii in fecal samples. Primer concentrations and annealing temperatures were optimized to minimize primer dimer formation, ensuring high specificity. Clinical evaluation was conducted using 771 fecal and nasal fluid samples collected from dairy farms in five regions. The I-ELISA method was developed using M. morganii lipoprotein (LPP) antigen. Parameters such as antigen coating, blocking conditions, and antibody dilution were optimized to improve specificity. Stability and reproducibility were validated through intra- and inter-assay tests. A total of 476 serum samples from dairy cows were tested to assess the method’s clinical applicability.ResultsThe optimized PCR method demonstrated high sensitivity and specificity, achieving a detection threshold of 0.2 CFU/μL. Clinical testing revealed a positivity rate of 1.4% among 771 fecal and nasal fluid samples. The I-ELISA method showed excellent stability and reproducibility, confirmed through intra- and inter-assay consistency. In testing 476 dairy cow serum samples, the positivity rate for M. morganii was 5.9%. These results indicate the utility of I-ELISA as a reliable serological diagnostic tool.DiscussionThe PCR and I-ELISA methods collectively offer practical solutions for the early clinical diagnosis of M. morganii infections in dairy cows. The PCR technique’s efficiency and sensitivity make it ideal for pathogen detection in fecal samples, while the I-ELISA method provides a robust platform for serological analysis. Together, these tools enable timely intervention, contributing to improved livestock health management and mitigating the negative impacts of M. morganii on dairy cow productivity. Future research may focus on further refining these techniques and exploring their applications in broader livestock management contexts.
Sensitivity to the Demethylation Inhibitor Difenoconazole Among Baseline Populations of Various Penicillium spp. Causing Blue Mold of Apples and Pears
Authors: Pandey Madan , Haskell Clayton L. , Cowell Juliette D. , Amiri Achour 
Published: January 2025

Difenoconazole (DIF), a demethylation inhibitor fungicide, was registered in 2016 for the control of postharvest diseases of pome fruits. In this study, 162 isolates from P. expansum (n = 31) and 13 other “non-expansum” Penicillium spp., i.e., P. solitum (n = 52), P. roqueforti (n = 32), P. commune (n = 15), P. paneum (n = 9), P. psychrosexuale (n = 8), P. crustosum (n = 5), P. carneum (n = 3), P. palitans (n = 2), along with one isolate each of P. citrinum, P. griseofulvum, P. raistrickii, P. ribium, and P. viridicatum, were collected from multiple packinghouses in the U.S. Pacific Northwest. In vitro sensitivity assays showed similar sensitivities of spores and mycelia across species with the mean EC50 values ranging from 0.01 for P. psychrosexuale (n = 8) to 1.33 μg mL−1 for P. palitans (n = 2), whereas the mean EC50s were 0.03, 0.12, 0.19, and 0.51 μg mL−1 for P. expansum (n = 31), P. paneum (n = 9), P. solitum (n = 52), and P. crustosum (n = 5), respectively. The recommended rate of DIF controlled P. expansum and P. roqueforti isolates but not all isolates of four other Penicillium spp. on Fuji apples after five months at 1.5 °C. The mixture of DIF + fludioxonil (FDL) (AcademyTM) controlled all the dual-sensitive isolates (DIFSFDLS) and DIF single-resistant (DIFR) isolates among the six species tested but not the FDLR and dual DIFRFDLR isolates. Notable polymorphism was detected in the CYP51 gene of the “non-expansum” species with four mutations located at four residues. Although the isolates analyzed in this study had not previously been exposed to DIF, the findings indicate variable sensitivity levels among the Penicillium spp.
КОМПЛЕКСНЫЙ ЭЛЕКТРОРАЗВЕДОЧНЫЙ МОНИТОРИНГ ПРОЦЕССОВ СОЛЯНОГО КАРСТООБРАЗОВАНИЯ
Authors: Колесников В.П. , Ласкина Т.А. 
Published: January 2025

Рассмотрено формирование прогнозной физико-динамической модели провалообразования на основе физико-геологической информации и анализа результатов мониторинговых электроразведочных работ по изучению динамики развития карстовых процессов в условиях соляного месторождения. Основной целью исследования является создание способов и технологий электрометрических наблюдений для прогнозной оценки стадийности развития провальных явлений.
Predictive dynamic geoelectrical model of sinkholes development has been formed on the base of physical-geological information and analysis of electrical monitoring surveys for investigation of karst processes dynamic in the context of a salt deposit. The main goal of the research is to develop approach and technology of electrical surveys to predict the stages of the sinkhole development processes.
ЛИЦО В МАСКЕ: ОТ ИСТОРИЧЕСКИХ РЕМИНИСЦЕНЦИЙ ДО СОВРЕМЕННЫХ ПОДРОСТКОВЫХ СУБКУЛЬТУР
Authors: Рягузова Елена Владимировна 
Published: January 2025

Актуализируется проблема маскировки человеком собственного присутствия в реальном мире, замены подлинности существования, его мотивов и цели, факторов и детерминант, применения маски в ритуальных практиках, игровой активности и профессиональной деятельности. Цель: проанализировать культурные прототипы маски в контексте онтологической константы Я - Другой и современные тренды ее использования в подростковых субкультурах. Выявляются инвариантные и специфические функции ритуальной, карнавальной и театральной маски. Описываются три современные подростковые субкультуры, связанные с переодеванием в вымышленных персонажей или зооморфных существ: косплей, фурри и квадробика. Анализируется социальная ситуация развития подростка - цифрового аборигена, обусловленная его нахождением в онлайн и офлайн смешанной реальности, рефлексия которой осуществляется в контексте трех основных сфер социализации: деятельность, общение и самосознание. Определяются основные функции маски в анализируемых субкультурах: маскировочная, предоставляющая защиту от взгляда Другого и выступающая барьером от самого себя; маркировочная, указывающая на принадлежность к группе Своих ; проективно-замещающая, связанная с безопасным экспериментированием с собственной идентичностью. Утверждается, что использование маски в подростковых субкультурах свидетельствует о продолжении инициации на уровне воображения и отрыве от реальности, игре с Я-образами и поиске внешней и внутренней поддержки.
The article actualises the problem of masking by a person of his/her own presence in the real world, replacing the authenticity of existence, its motives and goals, factors and determinants, the use of a mask in ritual practices, game and professional activity. Purpose: to analyse the cultural prototypes of the mask in the context of the ontological constant I - Other and modern trends of its use in adolescent subcultures. The invariant and specific functions of ritual, carnival and theatre masks are identified. Three modern teenage subcultures related to dressing up as fictional characters or zoomorphic creatures - cosplay, furry and quadrobics - are described. The article analyses the social situation of development of a teenager - a digital aborigine, conditioned by his/her presence in online and offline mixed reality, the reflection of which is carried out in the context of three main spheres of socialisation: activity, communication and self-consciousness. The main functions of the mask in the analysed subcultures are defined: masking, providing protection from the Other's gaze and acting as a barrier from oneself; marking, indicating belonging to the group of ‘one's own’; projective and substitution, associated with safe experimentation with one's own identity. It is argued that the use of a mask in adolescent subcultures indicates the continuation of initiation at the level of imagination and detachment from reality, playing with self-images and searching for external and internal support.
Sistem Kontrol Dan Pemantauan Berbasis IoT untuk Kenyamanan Ternak Unggas
Authors: Runtuwene David Christo , Poekoel Vecky C. , Manembu Pinrolinvic D.K. 
Published: January 2025

Abstract — Chicken farmers usually still use conventional methods, whereas cage cleaning is still done manually at uncertain times. Even though the cleanliness of the cage itself must be done regularly so that livestock avoid diseases caused by feces in the cage, because the ammonia threshold level produced by chicken feces should not exceed 25 ppm. In terms of chicken comfort, temperature also plays an important role in the brooding period, the temperature of the cage must be really warm and range between 30°C-34°C. To maintain ammonia levels and chicken coop temperature in accordance with health standards and chicken comfort, it is necessary to implement an IoT-based chicken coop control and monitoring system. This research focuses on a system for use on broiler breeding chicken farms whose support system uses IoT. This system uses a DHT22 sensor to measure the temperature and humidity of the cage and an MQ135 sensor to detect ammonia in the air. The ESP32 microcontroller is used as a controller as well as a network communication tool for the IoT system. The chicken coop's temperature and ammonia control system is successfully designed and can be monitored using the smartphone application via an internet connection.
Keywords — Chicken cage; Control and Monitoring; Internet of Things; Temperature and ammonia control.

Abstrak — Saat ini peternak ayam biasanya masih menggunakan cara konvensional, dimana pembersihan kandang masih dilakukan secara manual pada waktu yang tidak menentu. Padahal kebersihan kandang sendiri harus dilakukan secara teratur agar ternak terhindar dari penyakit yang disebabkan kotoran dalam kandang, sebab kadar ambang batas amonia yang dihasilkan oleh kotoran ayam tidak boleh melebihi 25 ppm. Dalam hal kenyamanan ayam, suhu juga berperan penting dalam masa pembesaran atau brooding, suhu kandang harus benar-benar hangat dan berkisar antara 30°C-34°C. Untuk menjaga kadar amonia serta suhu kandang ayam sesuai dengan standar kesehatan dan kenyamaan ayam, maka perlu diterapkan sistem kontrol dan monitoring kandang ayam berbasis IoT. Penelitian ini fokus pada sistem untuk digunakan pada peternakan ayam bibit ayam broiler yang sistem pendukungnya menggunakan IoT. Sistem ini menggunakan sensor DHT22 untuk mengukur suhu dan kelembapan kandang serta sensor MQ135 untuk mendeteksi amonia di udara. Adapun mikrokontroler ESP32 digunakan sebagai sebagai pengontrol sekaligus alat komunikasi jaringan untuk sistem IoT. Sistem kontrol suhu dan amonia pada kandang ayam berhasil dirancang dan dapat dipantau menggunakan aplikasi ponsel pintal melalui koneksi internet.
Kata kunci — IoT; Kandang Ayam; kontrol dan pemantauan; kontrol suhu dan amonia.
МЕТОДИКА КОМПЛЕКСНОГО АНАЛИЗА ГРАДОСТРОИТЕЛЬНОГО ПОТЕНЦИАЛА ТЕРРИТОРИЙ ПРОМЫШЛЕННОГО НАСЛЕДИЯ «СЕРОГО ПОЯСА» КОМИНТЕРНОВСКОГО РАЙОНА ГОРОДА ВОРОНЕЖА
Authors: ЗОЛОТУХИНА Я.А. , ТЮНИН Д.В. , МАКАРОВА Т.В. 
Published: January 2025

В данной статье рассмотрены основные тенденции редевеломпента «серого пояса», выявлены предпосылки эффективного использования бывших промышленных и деградирующих территорий, выполнен анализ «серого пояса» на территории Коминтерновского района города Воронеж, проведен SWOT-анализ редевеломпента бывших промышленных территорий, который позволил получить полное представление о существующей городской ситуации для принятия дальнейших проектных решений
In this article, the main trends of the redevelopment of the "gray belt" are considered, the prerequisites for the effective use of former industrial and degrading territories are identified, the analysis of the "gray belt" on the territory of the Kominternovsky district of Voronezh is performed, a SWOT analysis of the redevelopment of former industrial territories is carried out
Организация строительного производства с учетом управления рисками в процессе жизненного цикла объектов недвижимости
Authors: Мясищев Р.Ю. , Мищенко А.В. , Сергеев Ю.Д. 
Published: January 2025

В статье проводится анализ положения о методах, с помощью которых можно оценить риск инвестиционно-строительных проектов в зависимости от стадии жизненного цикла. Представлены характеристики каждого этапа жизненного цикла проекта в сфере недвижимости. Предложен алгоритм оценки риска. Выявлена взаимосвязь риска и качества информации, на основе которой оценивается риск в инвестиционно-строительной деятельности.
This article analyzes the provisions on the methods by which it is possible to assess the risk of investment and construction projects, depending on the stage of the project life cycle. The characteristics of each stage of the life cycle of a real estate project are presented. An algorithm for risk assessment is proposed. The interrelation of risk and the quality of information on the basis of which the risk in investment and construction activities is assessed is revealed.