bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex-Related Differences in Patients With Unexplained Syncope and Bundle Branch Block: Lower Risk of AV Block and Lesser Need for Cardiac Pacing in Women
Authors: Francisco-Pascual Jaume , Rivas-Gándara Nuria , Bach-Oller Montserrat , Badia-Molins Clara , Maymi-Ballesteros Manel , Benito Begoña , Pérez-Rodon Jordi , Santos-Ortega Alba , Sambola-Ayala Antonia , Roca-Luque Ivo , Cantalapiedra-Romero Javier , Rodríguez-Silva Jesús , Pascual-González Gabriel , Moya-Mitjans Àngel , Ferreira-González Ignacio 
Published: January 2023

Graphical AbstractRisk of AVB and need for cardiac pacing. Left: Percentage of patients diagnosed with aAVB/sCD in both sexes. Right-top: Multivariate logistic regression analyses for risk of aAVB/sCD. Odds ratio and 95% CI are plotted. Right-bottom: Kaplan-Meier pacemaker-free survival estimates curves in both sexes. aAVB/sCD, advanced atrio-ventricular block or severe conduction disturbances; HR, hazard ratio; CI, confidence interval; y.o, years old; IHD, ischemic heart disease; LVEF, left ventricular ejection fraction; BBB, bundle branch block; LBBB, left bundle branch block; RBBB, right bundle branch block; LAFB, left anterior fascicular block
Molecular Changes in Prepubertal Left Ventricular Development Under Experimental Volume Overload
Authors: Hu Yuqing , Li Debao , Zhou Chunxia , Xiao Yingying , Sun Sijuan , Jiang Chuan , Chen Lijun , Liu Jinfen , Zhang Hao , Li Fen , Hong Haifa , Ye Lincai 
Published: January 2023

Graphical AbstractA prepubertal LV VO mouse model was first established. VO has an important influence on LV maturation and development, especially in cardiac conduction, suggesting the requirement of an early correction of AR in pediatric patients.
Effect of Sodium-Glucose Cotransporter 2 Inhibitors for Heart Failure With Preserved Ejection Fraction: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Authors: Zhou Hufang , Peng Wenhua , Li Fuyao , Wang Yuelin , Wang Baofu , Ding Yukun , Lin Qian , Zhao Ying , Pan Guozhong , Wang Xian 
Published: January 2023

Graphical AbstractA systematic review and meta-analysis was performed to investigate the effect of sodium-glucose cotransporter 2 inhibitors for heart failure with preserved ejection fraction.
Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes
Authors: Li Wenjin , Zheng Jing , Xu Yao , Niu Weiran , Guo Dong , Cui Jianing , Bian Wenjin , Wang Xiaohui , Niu Jinliang 
Published: January 2023

ObjectivesTo observe the elongation of the axial tooth movement in the unopposed rodent molar model with type 1 diabetes mellitus and explore the pathological changes of periodontal ligament and alveolar bone, and their correlation with tooth axial movement.MethodsThe 80 C57BL/6J mice were randomly divided into the streptozotocin(STZ)-injected group (n = 50) and the control group (n = 30). Mice in the streptozotocin(STZ)-injected group were injected intraperitoneal with streptozotocin (STZ), and mice in the control group were given intraperitoneal injection of equal doses of sodium citrate buffer. Thirty mice were randomly selected from the successful models as the T1DM group. The right maxillary molar teeth of mice were extracted under anesthesia, and allowed mandibular molars to super-erupt. Mice were sacrificed at 0, 3, 6,9, and 12 days. Tooth elongation and bone mineral density (BMD) were evaluated by micro-CT analysis(0,and 12 days mice). Conventional HE staining, Masson staining and TRAP staining were used to observe the changes in periodontal tissue(0, 3, 6, 9, and 12 days mice). The expression differences of SPARC, FGF9, BMP4, NOGGIN, and type I collagen were analyzed by RT-qPCR.ResultsAfter 12 days of tooth extraction, our data showed significant super-eruption of mandibular mouse molars of the two groups. The amount of molar super-eruption in the T1DM group was 0.055mm( ± 0.014mm), and in the control group was 0.157( ± 0.017mm). The elongation of the T1DM mice was less than that of the control mice(P&lt;0.001). It was observed that the osteoclasts and BMD increased gradually in both groups over time. Compared with the control group, the collagen arrangement was more disordered, the number of osteoclasts was higher (P&lt;0.05), and the increase of bone mineral density was lower(2.180 ± 0.007g/cm3 vs. 2.204 ± 0.006g/cm3, P&lt;0.001) in the T1DM group. The relative expression of SPARC, FGF9, BMP4, and type I collagen in the two groups increased with the extension of tooth extraction time while NOGGIN decreased. The relative expression of all of SPARC, FGF9, BMP4, and type I collagen in the T1DM group were significantly lower, and the expression of NOGGIN was higher than that in the control group (P&lt;0.05).ConclusionThe axial tooth movement was inhibited in type 1 diabetic mice. The result may be associated with the changes of periodontal ligament osteoclastogenic effects and alveolar bone remodeling regulated by the extracellular matrix and osteogenesis-related factors.
The effects of three different low-volume aerobic training protocols on cardiometabolic parameters of type 2 diabetes patients: A randomized clinical trial
Authors: Gentil Paulo , Silva Lucas Raphael Bento e , Antunes Daniela Espíndola , Carneiro Luciana Barbosa , de Lira Claudio Andre Barbosa , Batista Gislene , Oliveira Jordana Campos Martins de , Cardoso John Sebastião , Souza Daniel CostaCosta , Rebelo Ana Cristina Silva 
Published: January 2023

ObjectiveTo compare the effects of different aerobic training protocols on cardiometabolic variables in patients with type 2 diabetes mellitus (T2DM).MethodsThis study was a parallel clinical trial. Fifty-two men and women with T2DM (&gt;40 years) were randomly allocated into three groups, and 44 (22 males/22 females) were included in the final analysis. Exercise intensity was based on the speed corresponding to the maximum oxygen consumption (vV˙O2max). Moderate intensity continuous training (MICT) involved 14 minutes at 70% of vV˙O2max; short interval high-intensity interval training (S-HIIT) consisted of 20 bouts of 30 seconds at 100% of V˙O2max with 30 seconds passive recovery; long interval high-intensity training (L-HIIT) consisted of 5 bouts of 2 minutes at 100% of vV˙O2max with 2 minutes passive recovery. Training protocols were performed on a motorized treadmill two times per week for eight weeks. Glycated hemoglobin (Hb1Ac), total cholesterol, triglycerides, resting systolic blood pressure (SBP), resting diastolic blood pressure (DBP), resting heart rate (resting HR) and maximum oxygen consumption (V˙O2max) were measured before and after the exercise intervention. The study was registered on the Brazilian clinical trial records (ID: RBR45 4RJGC3).ResultsThere was a significant difference between groups for changes on V˙O2max. Greater increases on V˙O2max were achieved for L-HIIT (p = 0.04) and S-HIIT (p = 0.01) in comparison to MICT group, with no significant difference between L-HIIT and S-HIIT (p = 0.9). Regarding comparison within groups, there were significant reductions on HbA1c and triglycerides levels only for L-HIIT (p&lt; 0.05). V˙O2max significantly increased for both L-HIIT (MD = 3.2 ± 1.7 ml/kg/min, p&lt; 0.001) and S-HIIT (MD = 3.4 ± 1.7, p&lt; 0.001). There was a significant reduction on resting SBP for L-HIIT group (MD = -12.07 ± 15.3 mmHg, p&lt; 0.01), but not for S-HIIT and MICT. There were no significant changes from pre- to post-training on fasting glycemia, total cholesterol, HDL, LDL, resting HR and resting DBP for any group (p &gt; 0.05).ConclusionLow-volume HIIT promoted greater improvements in cardiorespiratory capacity in comparison with low-volume MICT, independent of the protocols used. There were no other differences between groups. All protocols improved at least one of the variables analyzed; however, the most evident benefits were after the high-intensity protocols, especially L-HIIT.
Spatial confinement of sliver nanoparticles in nitrogen-doped carbon framework with high catalytic activity and long-term cycling
Authors: Yang Meng , Zhang Jingwu , Wang Jinming , Gao Wei , Liu Di , Li Lanjie , Wang Yimin , Peng Qiuming 
Published: January 2023

Graphical AbstractWe prepared a Ag NP@N-C-900 catalyst by a in-situ assisted spatial confinement method. This obtained Ag NP@N-C-900 possesses superior ORR performance with a half-wave potential of 0.83 V, excellent stability and methanol resistance ability. Attractively, the primary zinc–air battery based on the Ag NP@N-C-900 air-cathode offers a long cycle of 3600 minutes as well as excellent durability. The catalytic activity and stability exceed most of the Ag-based catalysts reported so far, and are completely comparable to commercially available Pt/C. Spatial confinement of sliver nanoparticles in nitrogen-doped carbon framework with high catalytic activity and long-term cycling.
Heat transfer enhancement and free convection assessment in a double-tube latent heat storage unit equipped with optimally spaced circular fins: Evaluation of the melting process
Authors: Shojaeinasab Chatroudi Ilia , Atashafrooz Meysam , Mohammed Hayder I. , Abed Azher M. , Talebizadehsardari Pouyan 
Published: January 2023

To overcome the weak conduction heat transfer of phase change materials (PCM), this investigation aimed to assess the behavior of a double-tube latent heat storage unit with circular fins through the charging process. The influence of free convection in the presence of fins of various arrangements and sizes was comprehensively studied. The geometrical characteristics of the fins, i.e., their size and number, were assessed to optimize their performance. Moreover, a sensitivity assessment was performed on the characteristics of the heat transfer fluid passing through the inner tube, i.e., the Reynolds number and temperature. Charging time diminished by 179% when nine 15 mm fins were added compared with the finless scenario, assuming the same phase change materials volume. Moreover, the system’s thermal recovery rate improved from 20.5 to 32.9 W when nine fins with the heigth of 15 mm were added. The use of more fins improved the thermal behavior of the phase change materials because of the higher total fin area. The melting time and heat storage rate changed by 76% and 71%, respectively, for the system with 19 fins compared with those with four fins. Moreover, the outcomes indicated that a higher heat storage rate can be achieved when the working medium’s faster flow and inlet temperature were used.
Particle-size fractal dimensions and pore structure characteristics of soils of typical vegetation communities in the Kubuqi Desert
Authors: Sun Kai , Wang Han , Pei Zhiyong , Wang Haichao , Sun Xiaotian , Li Ying , Sun Guirong , Alatengsuhe  , Yang Jianjun , Su Xiaoming 
Published: January 2023

The goal of this study was to investigate the soil particle-size distribution (PSD) and pore structure characteristics in the Kubuqi Desert in order to provide basic data for gaining insights into the soil-modifying properties of the local vegetation. Based on laser diffraction analysis, we measured the soil PSD and calculated the single and multi-fractal dimensions of the soils under typical artificial forest and natural grassland vegetation. The diameters, volumes and surface areas of the soil pores were determined via nitrogen adsorption experiments. The relationships between the fractal characteristics and pore structure parameters of the soil were investigated via redundancy analysis and stepwise regression. The clay content was less than 2.0%, and the sand content was greater than 75.0%. There was variability in the PSD and fractal dimension, which was mainly observed for the 0–20 cm, 20–80 cm, and 80–100 cm soil layers. In the 0–80 cm, the fine particle content, single fractal dimension (D), entropy dimension (D1), ratio of D1 to the capacity dimension (D1/D0), and correlation dimension (D2) were smaller for the forest soils than for the grassland soils. The fine particle (clay and silt) content of the 80–100 cm soil layer was approximately 37.8% higher for the Salix psammophila-8a than for the Salix psammophila-3a, and it was approximately 161.4% higher for the Populus popular-35a than for the Pinus sylvestris var. mongolica-8a. The silt content, D1, D1/D0, and D2 were significantly positively correlated with the specific surface area (SSA), total pore volume (TPV), and average pore diameter (APD) of the nanopores (p &lt; 0.05, 0.01, or 0.001), and they were significantly negatively correlated with the percentage of the micropore volume (PMV) (p &lt; 0.05 or 0.01). In the Kubuqi Desert, the fine particle content and fractal dimensions of the soil layer below the root zone of shrub and arbor vegetation increased with increasing stand age, but the trend was reversed in the shallower soil layers. The variability of the soil PSD characteristics was strongly correlated with the variability of the nanopore parameters on the microscopic scale, suggesting that the total pore volume, average pore diameter, and percentage of the micropore volume may be potential indicators of the soil structure and quality.
The LncRNA signature associated with cuproptosis as a novel biomarker of prognosis in immunotherapy and drug screening for clear cell renal cell carcinoma
Authors: Zhang Lishuo , Di Longjiang , Liu Jinhui , Lei Xianli , Gu Maoli , Zhang Wenjing , Wang Yufu 
Published: January 2023

Cuproptosis is a new form of cell death, the second form of metal ion-induced cell death defined after ferroptosis. Recently, cuproptosis has been suggested to be associated with tumorigenesis. However, the relationship between cuproptosis and patient prognosis in clear cell renal cell carcinoma (ccRCC) in the context of immunotherapy remains unknown. The aim of this study was to investigate the correlation between cuproptosis-related long non-coding RNA (lncRNA) and ccRCC in terms of immunity as well as prognosis. Clinical information on lncRNAs associated with differences in cuproptosis genes in ccRCC and normal tissues was collected from The Cancer Genome Atlas (TCGA) dataset. Univariate Cox regression was used to screen lncRNAs. A total of 11 lncRNAs closely associated with cuproptosis were further screened and established using the least absolute shrinkage and selection operator (LASSO) algorithm and multivariate Cox regression, and the samples were randomly divided into training and test groups. A risk prognostic model was constructed using the training group, and the model was validated using the test group. We investigated the predictive ability of the prognostic risk model in terms of clinical prognosis, tumor mutation, immune escape, immunotherapy, tumor microenvironment, immune infiltration levels, and tumor drug treatment of ccRCC. Using the median risk score, patients were divided into low and high-risk groups. Kaplan-Meier curves showed that the overall survival (OS) of patients in the high-risk group was significantly worse than low-risk group (p &lt; 0.001). Receiver operating characteristic (ROC) curves further validated the reliability of our model. The model consistently and accurately predicted prognosis at 1, 3, and 5 years, with an AUC above 0.7. Tumor cell genes generally precede morphological abnormalities; therefore, the model we constructed can effectively compensate for the traditional method of evaluating the prognosis of patients with renal cancer, and our model was also clinically meaningful in predicting ccRCC staging. In addition, lower model risk scores determined by mutational load indicated a good chance of survival. The high-risk group had greater recruitment of immune cells, while the anti-immune checkpoint immunotherapy was less efficacious overall than that of the low-risk group. Tumor and immune-related pathways were enriched, and anti-tumor agents were selected to improve the survival of ccRCC. This prognostic risk model is based on the levels of cuproptosis-associated lncRNAs and provides a new perspective in the clinical assessment and precise treatment of ccRCC.
Ancestry: How researchers use it and what they mean by it
Authors: Dauda Bege , Molina Santiago J. , Allen Danielle S. , Fuentes Agustin , Ghosh Nayanika , Mauro Madelyn , Neale Benjamin M. , Panofsky Aaron , Sohail Mashaal , Zhang Sarah R. , Lewis Anna C. F. 
Published: January 2023

Background: Ancestry is often viewed as a more objective and less objectionable population descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is rapidly growing in genetics research, with ancestry groups referenced in many situations. The appropriate usage of population descriptors in genetics research is an ongoing source of debate. Sound normative guidance should rest on an empirical understanding of current usage; in the case of ancestry, questions about how researchers use the concept, and what they mean by it, remain unanswered.Methods: Systematic literature analysis of 205 articles at least tangentially related to human health from diverse disciplines that use the concept of ancestry, and semi-structured interviews with 44 lead authors of some of those articles.Results: Ancestry is relied on to structure research questions and key methodological approaches. Yet researchers struggle to define it, and/or offer diverse definitions. For some ancestry is a genetic concept, but for many—including geneticists—ancestry is only tangentially related to genetics. For some interviewees, ancestry is explicitly equated to ethnicity; for others it is explicitly distanced from it. Ancestry is operationalized using multiple data types (including genetic variation and self-reported identities), though for a large fraction of articles (26%) it is impossible to tell which data types were used. Across the literature and interviews there is no consistent understanding of how ancestry relates to genetic concepts (including genetic ancestry and population structure), nor how these genetic concepts relate to each other. Beyond this conceptual confusion, practices related to summarizing patterns of genetic variation often rest on uninterrogated conventions. Continental labels are by far the most common type of label applied to ancestry groups. We observed many instances of slippage between reference to ancestry groups and racial groups.Conclusion: Ancestry is in practice a highly ambiguous concept, and far from an objective counterpart to race or ethnicity. It is not uniquely a “biological” construct, and it does not represent a “safe haven” for researchers seeking to avoid evoking race or ethnicity in their work. Distinguishing genetic ancestry from ancestry more broadly will be a necessary part of providing conceptual clarity.
Cuproptosis-related gene FDX1 as a prognostic biomarker for kidney renal clear cell carcinoma correlates with immune checkpoints and immune cell infiltration
Authors: Yao Yimin , Chen Haixin , Lou Minjun , Chen Tingting 
Published: January 2023

Background: Kidney renal clear cell carcinoma (KIRC) is not sensitive to radiotherapy and chemotherapy, and only some KIRC patients can benefit from immunotherapy and targeted therapy. Cuproptosis is a new mechanism of cell death, which is closely related to tumor progression, prognosis and immunity. The identification of prognostic markers related to cuproptosis in KIRC may provide targets for treatment and improve the prognosis of KIRC patients.Methods: Ten cuproptosis-related genes were analyzed for differential expression in KIRC-TCGA and a prognostic model was constructed. Nomogram diagnostic model was used to screen independent prognostic molecules. The screened molecules were verified in multiple datasets (GSE36895 and GSE53757), and in KIRC tumor tissues by RT-PCR and immunohistochemistry (IHC). Clinical correlation of cuproptosis-related independent prognostic molecules was analyzed. According to the molecular expression, the two groups were divided into high and low expression groups, and the differences of immune checkpoint and tumor infiltrating lymphocytes (TILs) between the two groups were compared by EPIC algorithm. The potential Immune checkpoint blocking (ICB) response of high and low expression groups was predicted by the “TIDE” algorithm.Results: FDX1 and DLAT were protective factors, while CDKN2A was a risk factor. FDX1 was an independent prognostic molecule by Nomogram, and low expressed in tumor tissues compared with adjacent tissues (p &lt; 0.05). FDX1 was positively correlated with CD274, HAVCR2, PDCD1LG2, and negatively correlated with CTLA4, LAG3, and PDCD1. The TIDE score of low-FDX1 group was higher than that of high-FDX1 group. The abundance of CD4+ T cells, CD8+ T cells and Endothelial cells in FDX1-low group was lower than that in FDX1-high group (p &lt; 0.05).Conclusion: FDX1, as a key cuproptosis-related gene, was also an independent prognostic molecule of KIRC. FDX1 might become an interesting biomarker and potential therapeutic target for KIRC.
Pregnancy loss: Consequences for mental health
Authors: Cuenca Diana 
Published: January 2023

Pregnancy loss, in all its forms (miscarriage, abortion, and fetal death), is one of the most common adverse pregnancy outcomes, but the psychological impact of such loss is often underestimated. The individual response to this outcome may vary between women—and could be influenced by age, race, culture, or religious beliefs—but most experience anxiety, stress, and symptoms of depression. Because pregnancy loss is not uncommon, health providers are used to dealing with this diagnosis, however the correct management of the process of diagnosis, information-gathering, and treatment can greatly ameliorate the adverse mental consequences for these women. The aim of this review is to examine the different types of pregnancy loss, and consider how each can influence the mental health of the women affected and their partners—in both the short- and long-term; to review the risk factors with the aim of identifying the women who may be at risk of consequential mental health problems; and to provide some advice for health providers to help these women better cope with pregnancy loss. Finally, we provide some points for health providers to follow in order to aid the management of a pregnancy loss, particularly for spontaneous, induced, or recurrent miscarriage, or stillbirth.
Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli
Authors: Ismailova Aiten , Salehi-Tabar Reyhaneh , Dimitrov Vassil , Memari Babak , Barbier Camille , White John H. 
Published: January 2023

IntroductionNeutrophils represent the largest proportion of circulating leukocytes and, in response to inflammatory stimuli, are rapidly recruited to sites of infection where they neutralize pathogens.Methods and resultsWe have identified a novel neutrophil transcription network induced in response to inflammatory stimuli. We performed the first RNAseq analysis of human neutrophils exposed to lipopolysaccharide (LPS), followed by a meta-analysis of our dataset and previously published studies of LPS-challenged neutrophils. This revealed a robustly enhanced transcriptional network driven by forkhead box (FOX) transcription factors. The network is enriched in genes encoding proinflammatory cytokines and transcription factors, including MAFF and ATF3, which are implicated in responses to stress, survival and inflammation. Expression of transcription factors FOXP1 and FOXP4 is induced in neutrophils exposed to inflammatory stimuli, and potential FOXP1/FOXP4 binding sites were identified in several genes in the network, all located in chromatin regions consistent with neutrophil enhancer function. Chromatin immunoprecipitation (ChIP) assays in neutrophils confirmed enhanced binding of FOXP4, but not FOXP1, to multiple sites in response to LPS. Binding to numerous motifs and transactivation of network genes were also observed when FOXP proteins were transiently expressed in HEK293 cells. In addition to LPS, the transcriptional network is induced by other inflammatory stimuli, indicating it represents a general neutrophil response to inflammation.DiscussionCollectively, these findings reveal a role for the FOXP4 transcription network as a regulator of responses to inflammatory stimuli in neutrophils.