bluuebunny/crossref_metadata_2025_split huggingface dataset:
HLA–DRB1*15 and Eosinophilia Are Common Among Patients With Systemic Juvenile Idiopathic Arthritis
Authors: Lerman Alison M. , Mahmud Shawn A. , Alfath Zineb , Langworthy Benjamin W. , Hobday Patricia M. , Riskalla Mona M. , Binstadt Bryce A. 
Published: April 2023

ObjectiveConcern exists that medications used to treat patients with systemic juvenile idiopathic arthritis (JIA), particularly interleukin (IL)‐1 and IL‐6 blocking agents, might be causing adverse drug reactions and lung disease (systemic JIA‐LD). Carriage of HLA–DRB1*15 has been reported as a risk factor for adverse drug reactions among patients with systemic JIA. We performed a retrospective chart review to evaluate these factors at our center.MethodsWe reviewed the records of 86 subjects with systemic JIA followed for at least 6 months between 1996 and 2022. HLA typing was performed in 23 of the subjects. We compared characteristics of patients with or without eosinophilia. Among patients with HLA typing, we compared clinical characteristics of subjects with or without DRB1*15 and with or without systemic JIA‐LD.ResultsAmong the 23 patients with HLA typing, 74% carried DRB1*15, and 63% of patients without systemic JIA‐LD carried DRB1*15. Seven subjects had systemic JIA‐LD, all of whom carried DRB1*15. Patients with systemic JIA‐LD were younger at the time of diagnosis and more likely to have had macrophage activation syndrome. Exposure to IL‐1 and IL‐6 blockers was common, occurring in 95% of patients. Eosinophilia occurred in 39% of patients with systemic JIA, often before IL‐1 or IL‐6 blockade. Eosinophilia was associated with adverse drug reactions and macrophage activation syndrome. There was 1 death, unrelated to active systemic JIA disease.ConclusionCarriage of DRB1*15 was more common in this cohort of patients with systemic JIA than in the general population. Eosinophilia and systemic JIA‐LD were more common among patients with severe systemic JIA complicated by macrophage activation syndrome.
Leader‐following consensus of a class of heterogeneous uncertain multi‐agent systems with a distributed model reference adaptive control law
Authors: Naleini Maryam Nicole , Koru Ahmet Taha , Lewis Frank L. 
Published: April 2023

SummaryThis paper considers the leader‐following consensus problem of a multi‐agent system whose agents have heterogeneous uncertain dynamics in homogeneous state dimensions. Each agent utilizes a distributed model reference adaptive control (MRAC) law to deal with uncertainties. The nominal part of the MRAC is a distributed static state feedback control law. The reference model is the leader‐following consensus problem of reference agents with homogeneous linear time‐invariant dynamics. This problem becomes an N‐player graphical differential game under a given cost function. The reference agents utilize distributed static state feedback controllers that constitute a Nash equilibrium solution to the graphical differential game. This paper provides the conditions for the distributed MRAC to guarantee that each agent asymptotically tracks the corresponding reference agent; consequently, the multi‐agent system solves the leader‐following consensus problem as the reference model does. These conditions yield a straightforward design method for the MRAC. A numerical example demonstrates an application of the proposed approach to a multi‐robot system with nonlinear dynamics.
Enabling High‐Performance Artificial Muscles via a High Strength Fiber Reinforcement Strategy
Authors: Zhu Zhendong , Luo Longbo , Wang Jiayu , Liu Shi , Wu Kai , Wang Yinghan , Liu Xiangyang , Qin Jiaqiang , Cheng Pei 
Published: April 2023

AbstractCoiled‐polymer‐fiber‐based artificial muscles can provide large contractile actuation stroke. However, it is a challenge to achieve high actuation load and high actuation stroke for artificial muscle simultaneously. Herein, a powerful coiled‐polymer‐fiber‐based artificial muscle with a “rigid‐and‐flexible” structure is fabricated by cotwisting rigid heterocyclic aramid (HA) fibers with flexible silver‐plated nylon (SPN) fibers. The artificial muscle based on coiled HA@SPN fibers can lift a load over 108 MPa with a fast response time of 0.6 s, which is 309 times heavier than the load that human muscle can lift, and generate a work density per temperature of 41.3 J (kg °C)−1. The coiled HA@SPN fiber muscle exhibits high actuation stability of over 30 000 cycles. The coiled HA@SPN fiber muscle can provide a contractile actuation stroke of up to 8.2% and generate an average gravimetric mechanical energy density of 702 J kg−1, which is 18.1 times that of human skeletal muscle (≈38.8 J kg−1). An average contractile power density of 1168 W kg−1 is obtained for coiled HA@SPN fiber muscle, which is 23.4 times that of human skeletal muscle (≈50 W kg−1).
Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration
Authors: Javanmardi Yousef , Agrawal Ayushi , Malandrino Andrea , Lasli Soufian , Chen Michelle , Shahreza Somayeh , Serwinski Bianca , Cammoun Leila , Li Ran , Jorfi Mehdi , Djordjevic Boris , Szita Nicolas , Spill Fabian , Bertazzo Sergio , Sheridan Graham K , Shenoy Vivek , Calvo Fernando , Kamm Roger , Moeendarbary Emad 
Published: April 2023

AbstractCancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues. While cancer research has mostly focused on the biomechanical interactions between tumor cells (TCs) and ECM, particularly at the primary tumor site, very little is known about the mechanical properties of endothelial cells and the subendothelial ECM and how they contribute to the extravasation process. Here, an integrated experimental and theoretical framework is developed to investigate the mechanical crosstalk between TCs, endothelium and subendothelial ECM during in vitro cancer cell extravasation. It is found that cancer cell actin‐rich protrusions generate complex push–pull forces to initiate and drive TEM, while transmigration success also relies on the forces generated by the endothelium. Consequently, mechanical properties of the subendothelial ECM and endothelial actomyosin contractility that mediate the endothelial forces also impact the endothelium's resistance to cancer cell transmigration. These results indicate that mechanical features of distant tissues, including force interactions between the endothelium and the subendothelial ECM, are key determinants of metastatic organotropism.
Age‐related survey of clinical genetics literature and related resources
Authors: Solomon Amelia M. , Solomon Benjamin D. 
Published: April 2023

AbstractGenetic conditions affect people throughout their entire lifespan; however, many clinical geneticists focus on the care of pediatric individuals. We analyzed the medical literature and related resources to help assess to what extent adults with genetic diseases were represented. This included general literature searches of PubMed (from 2001 through 2022), specific databases (the FDA orphan drug list and the Clinical Genomic Database) related to management and direct treatment of genetic conditions, and textbooks and morphology guides relevant to the diagnosis of genetic conditions. In the field of genetics/genomics in general, we overall detected a statistically significant emphasis on pediatric populations in the medical literature compared to select other disciplines and compared with the global population distribution. Clinical genetics articles about adults tended to focus on younger adult ages. In clinical genetics, management and treatments, as well as illustrations in several educational/diagnostic resources tended to focus on pediatric populations.
Acenaphthoimidazolylidene‐ligated chiral oxazoline palladacycles: synthesis, structure, and application in intramolecular α‐arylation of amides towards 3,3′‐disubstituted oxindoles
Authors: Yang Hanxiao , Wang Kun , Fang Weiwei 
Published: April 2023

AbstractA general catalytic protocol for the Pd‐catalyzed intramolecular arylations of N‐(2‐halogenoaryl) amides in eco‐friendly medium was successfully developed by using rationally designed acenaphthoimidazolylidene‐ligated chiral oxazoline palladacycles. Under the optimal reaction condition, a broad scope of substrates with various functional groups were well tolerated, leading to desired 3,3′‐disubstituted oxindoles in excellent yields (up to 98% yield).
Stability‐indicating method development and validation for quantitative estimation of assay and organic impurities of antiviral drug baloxavir marboxil in drug substance and pharmaceutical dosage form using HPLC and LC–MS methods
Authors: Nagulancha Bhujanga Rao , Lakka Narasimha Swamy , Vandavasi Koteswara Rao 
Published: April 2023

AbstractBaloxavir marboxil (BXM) is a polymerase acidic endonuclease inhibitor used as an antiviral drug. A simple, reliable, and robust liquid chromatographic method was developed and validated per International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Q2(R1) for estimating the assay and impurities of BXM in drug substance and pharmaceutical formulations. The chromatographic separation was carried out on C18 (100 × 4.6 mm, 5 μm) with binary solvent delivery system (A:0.1% trifluoroacetic acid in water; B:0.1% trifluoroacetic‐acid in acetonitrile) along with detection wavelength of 260 nm, column temperature of 57°C, flow of 1.2 mL/min and injection volume of 10 μL. All five known impurities and unknown impurities were separated well with resolution >1.7 and were estimated accurately without any interference. Recovered values and regression value were 99.5%–101.2% and R2 > 0.999, respectively. The recovery and linearity studies covered from 50% to 150% for assay, and quantitation limit, 120% for five BXM impurities. Stability‐indicating property of the HPLC developed method was assessed from the forced degradation studies. The mass spectral data of unknown impurity formed under oxidation stress condition were discussed. The developed method was also successfully utilized for stability sample analysis of drug substance and tablet dosage form.
Consumptive and nonconsumptive effects of omnivorous tadpoles on aquatic invertebrate communities
Authors: Parlato Brady P. , Mott Cy L. 
Published: April 2023

AbstractConsumptive effects (CEs) of predation have been well‐studied in most aquatic systems, but nonconsumptive effects (NCEs) on prey have only recently received limited attention. As aquatic consumers, tadpoles have traditionally been considered strict herbivores, leaving their predatory impacts via CEs and NCEs largely unexplored. We quantified omnivory among wood frog (Lithobates sylvaticus) tadpoles and characterized their CEs and NCEs on invertebrate communities. Tadpoles from natural ponds were dissected to quantify the frequency of omnivory generally, as well as specifically in relation to pond size and tadpole morphology. Additional tadpoles were employed in a mesocosm experiment that manipulated tadpole presence (absent, caged, or free‐swimming) to quantify CEs and NCEs on freshwater zooplankton and macroinvertebrate communities. Over 70% of tadpoles in natural ponds engaged in omnivory, primarily on zooplankton, and tadpoles with wider heads and deeper tails were more likely to be omnivorous. Tadpoles in mesocosms exhibited CEs and NCEs on invertebrate communities, with stronger effects exerted on zooplankton than macroinvertebrates. The NCEs of tadpoles on invertebrates likely included production of predatory chemical cues that influenced invertebrate behavior, abundance, and community composition. Because tadpoles are often the dominant vertebrate predators in ephemeral aquatic ecosystems, this study stresses their ecological importance in structuring aquatic communities.
The central role of the left inferior longitudinal fasciculus in the face‐name retrieval network
Authors: Burkhardt Eléonor , Zemmoura Ilyess , Hirsch Fabrice , Lemaitre Anne‐Laure , Deverdun Jeremy , Moritz‐Gasser Sylvie , Duffau Hugues , Herbet Guillaume 
Published: April 2023

AbstractUnsuccessful retrieval of proper names (PNs) is commonly observed in patients suffering from neurological conditions such as stroke or epilepsy. While a large body of works has suggested that PN retrieval relies on a cortical network centered on the left anterior temporal lobe (ATL), much less is known about the white matter connections underpinning this process. Sparse studies provided evidence for a possible role of the uncinate fasciculus, but the inferior longitudinal fasciculus (ILF) might also contribute, since it mainly projects into the ATL, interconnects it with the posterior lexical interface and is engaged in common name (CN) retrieval. To ascertain this hypothesis, we assessed 58 patients having undergone a neurosurgery for a left low‐grade glioma by means of a famous face naming (FFN) task. The behavioural data were processed following a multilevel lesion approach, including location‐based analyses, voxel‐based lesion‐symptom mapping (VLSM) and disconnection‐symptom mapping. Different statistical models were generated to control for sociodemographic data, familiarity, biographical knowledge and control cognitive performances (i.e., semantic and episodic memory and CN retrieval). Overall, VLSM analyses indicated that damage to the mid‐to‐anterior part of the ventro‐basal temporal cortex was especially associated with PN retrieval deficits. As expected, tract‐oriented analyses showed that the left ILF was the most strongly associated pathway. Our results provide evidence for the pivotal role of the ILF in the PN retrieval network. This novel finding paves the way for a better understanding of the pathophysiological bases underlying PN retrieval difficulties in the various neurological conditions marked by white matter abnormalities.
Incidence and predictive factors of retropharyngeal lymph node metastases in patients with oropharyngeal cancer undergoing multimodality treatment planning imaging
Authors: Lavigne Danny , De‐Meric‐de‐Bellefon Mailys , Nguyen‐Tan Felix‐Phuc , Landry David , Létourneau‐Guillon Laurent , Bélair Manon , O'Sullivan Brian , Filion Edith , Bahig Houda 
Published: April 2023

AbstractBackgroundWe investigated the incidence and predictive factors of retropharyngeal lymph node (RPLN) metastases in patients with oropharyngeal cancer (OPC) undergoing multimodality treatment planning imaging before radiotherapy.MethodsConsecutive patients with OPC treated with curative‐intent radiotherapy from 2017 to 2019 were retrospectively analyzed. Treatment planning comprised contrast‐enhanced computed tomography (CT), magnetic resonance imaging (MRI), and fluorodeoxyglucose‐positron emission tomography (FDG‐PET) unless contraindicated.ResultsOf 300 patients, 66 (22%) had radiological evidence of RPLN involvement on planning images, compared to 17 (6%) on diagnostic CT alone. On multivariate analysis, RPLN involvement was statistically (p < 0.05) associated with tonsil, soft palate, and posterior pharyngeal wall primaries, and with disease extension to the soft palate or vallecula.ConclusionsMultimodality treatment planning imaging reveals a high rate of RPLN metastases from OPC compared to diagnostic CT alone. Patients with tonsil, soft palate, or posterior pharyngeal wall primaries or disease extending to the soft palate or vallecula appear at higher risk.
Left testicular and pulmonary metastases of mucinous adenocarcinoma of the prostate after robot‐assisted radical prostatectomy
Authors: Kato Kisumi , Kamei Jun , Yanase Atsushi , Yokoyama Hirotaka , Sugihara Toru , Ando Satoshi , Hirota Yuka , Sano Naoki , Kume Haruki , Fujimura Tetsuya 
Published: April 2023

IntroductionWe present a case of mucinous adenocarcinoma of the prostate with testicular and lung metastases following robot‐assisted radical prostatectomy, androgen deprivation therapy, and radiotherapy.Case presentationA 73‐year‐old man with a prostate‐specific antigen level of 4.3 ng/mL was diagnosed with prostate cancer. Following the robot‐assisted radical prostatectomy, the pathological diagnosis was mucinous adenocarcinoma of the prostate (pT3bpN0, Gleason score of 4 + 4). Salvage hormonal therapy and irradiation were performed after the prostatectomy. Enlargement of the left testis was noted, and 28 months after prostatectomy, computed tomography detected a left testicular tumor and nodular lesions in the bilateral lungs. The histopathological diagnosis of left high orchiectomy was metastasis of a mucinous adenocarcinoma of the prostate. Chemotherapy with docetaxel followed by cabazitaxel was initiated.ConclusionMucinous prostate adenocarcinoma with distal metastases following prostatectomy has been managed for longer than 3 years with multiple treatments.
Multi‐branch sustainable convolutional neural network for disease classification
Authors: Naz Maria , Shah Munam Ali , Khattak Hasan Ali , Wahid Abdul , Asghar Muhammad Nabeel , Rauf Hafiz Tayyab , Khan Muhammad Attique , Ameer Zoobia 
Published: April 2023

AbstractPandemic and natural disasters are growing more often, imposing even more pressure on life care services and users. There are knowledge gaps regarding how to prevent disasters and pandemics. In recent years, after heart disease, corona virus disease‐19 (COVID‐19), brain stroke, and cancer are at their peak. Different machine learning and deep learning‐based techniques are presented to detect these diseases. Existing technique uses two branches that have been used for detection and prediction of disease accurately such as brain hemorrhage. However, existing techniques have been focused on the detection of specific diseases with double‐branches convolutional neural networks (CNNs). There is a need to develop a model to detect multiple diseases at the same time using computerized tomography (CT) scan images. We proposed a model that consists of 12 branches of CNN to detect the different types of diseases with their subtypes using CT scan images and classify them more accurately. We proposed multi‐branch sustainable CNN model with deep learning architecture trained on the brain CT hemorrhage, COVID‐19 lung CT scans and chest CT scans with subtypes of lung cancers. Feature extracted automatically from preprocessed input data and passed to classifiers for classification in the form of concatenated feature vectors. Six classifiers support vector machine (SVM), decision tree (DT), K‐nearest neighbor (K‐NN), artificial neural network (ANN), naïve Bayes (NB), linear regression (LR) classifiers, and three ensembles the random forest (RF), AdaBoost, gradient boosting ensembles were tested on our model for classification and prediction. Our model achieved the best results on RF on each dataset. Respectively, on brain CT hemorrhage achieved (99.79%) accuracy, on COVID‐19 lung CT scans achieved (97.61%), and on chest CT scans dataset achieved (98.77%).
Loop technique for guidewire manipulation during endoscopic ultrasound‐guided hepaticogastrostomy
Authors: Miwa Haruo , Sugimori Kazuya , Matsuoka Yuto , Endo Kazuki , Oishi Ritsuko , Nishimura Masaki , Tozuka Yuichiro , Kaneko Takashi , Numata Kazushi , Maeda Shin 
Published: April 2023

AbstractBackground and AimEndoscopic ultrasound‐guided hepaticogastrostomy (EUS‐HGS) is widely used in the management of biliary obstructions; however, literature on guidewire manipulation is lacking. This study aimed to assess the utility and optimal conditions of the loop technique for guidewire manipulation during EUS‐HGS.MethodsConsecutive patients who underwent EUS‐HGS between April 2015 and January 2022 were included in this study. Patient characteristics and procedural details were retrospectively analyzed. Guidewire manipulations were classified as conventional technique or loop technique, based on the shape of the guidewire tip.ResultsA total of 52 patients (Median age: 73 years, 38 male and 14 female) underwent EUS‐HGS. The median guidewire insertion time was 49 s and the median overall procedure time was 20.5 min. The initial guidewire direction was toward the peripheral side in 23 patients (44%). Technical success rate of the EUS‐HGS was 100%. Twenty patients (38%) underwent the procedure using the loop technique and 32 (62%) with the conventional technique. In the logistic regression analysis, an angle between the bile duct and needle of >70° was independently associated with use of the loop technique (OR 9.84; 95% CI: 2.24–43.13; P <0.01).ConclusionThis study revealed the utility of the loop technique in EUS‐HGS. This technique is recommended if the bile duct is punctured at an angle >70°.
Promoting appropriate midline catheter and PICC placement through implementation of an EHR‐based clinical decision support tool: An interrupted time‐series analysis
Authors: Bredenberg Erin , Atwater Riannon , Grimm Eric , Chopra Vineet , Dale Shamburger Christopher , Anstett Tyler J. 
Published: April 2023

AbstractBackgroundInappropriate use of peripherally inserted central catheters (PICCs), including multilumen PICCs, may increase the risk of patient complications.ObjectiveImplement computerized decision support to: (a) increase the use of midline catheters over PICCs when appropriate and (b) decrease PICC lumens when a PICC is necessary.DesignsQuasi‐experimental, interrupted time series.SettingSingle tertiary academic medical center.PatientsHospitalized adults who received a midline or PICC during clinical care.InterventionDecision support on appropriate vascular access device choice via a set of electronic orders embedded within the electronic health record.MeasurementsProportion of midline catheter and single‐lumen PICCs placed between January 2, 2017 and November 19, 2017 (preintervention) versus November 20, 2017 to December 1, 2019 (postintervention).ResultsA total of 8758 midline and PICCs were inserted during the study period. A statistically significant increase in the insertion of midline catheters was observed during the intervention (p = .006). In parallel, single‐lumen PICC insertion as a proportion of all PICCs also increased after the intervention (p = .035). Results were consistent across multiple disciplines, including internal medicine, surgery, and intensive care. After considering the hospital census, total PICC and midline utilization rates and rates of complications did not change over time. However, an increase in catheter exchanges from less to more invasive devices occurred.ConclusionsIn this single‐center study, the implementation of electronic decision support to inform appropriate catheter use led to a more appropriate midline catheter and single‐lumen PICC insertion. Dissemination of this single, effective intervention to examine efficacy in other hospital settings would be welcomed.