bluuebunny/crossref_metadata_2025_split huggingface dataset:
The TeleKidSeq pilot study: incorporating telehealth into clinical care of children from diverse backgrounds undergoing whole genome sequencing
Authors: Sebastin Monisha , Odgis Jacqueline A. , Suckiel Sabrina A. , Bonini Katherine E. , Di Biase Miranda , Brown Kaitlyn , Marathe Priya , Kelly Nicole R. , Ramos Michelle A. , Rodriguez Jessica E. , Aguiñiga Karla López , Lopez Jessenia , Maria Estefany , Rodriguez Michelle A. , Yelton Nicole M. , Cunningham-Rundles Charlotte , Gallagher Katie , McDonald Thomas V. , McGoldrick Patricia E. , Robinson Mimsie , Rubinstein Arye , Shulman Lisa H. , Wolf Steven M. , Yozawitz Elissa , Zinberg Randi E. , Abul-Husn Noura S. , Bauman Laurie J. , Diaz George A. , Ferket Bart S. , Greally John M. , Jobanputra Vaidehi , Gelb Bruce D. , Horowitz Carol R. , Kenny Eimear E. , Wasserstein Melissa P. 
Published: March 2023

Abstract
Background
The COVID-19 pandemic forced healthcare institutions and many clinical research programs to adopt telehealth modalities in order to mitigate viral spread. With the expanded use of telehealth, there is the potential to increase access to genomic medicine to medically underserved populations, yet little is known about how best to communicate genomic results via telehealth while also ensuring equitable access. NYCKidSeq, a multi-institutional clinical genomics research program in New York City, launched the TeleKidSeq pilot study to assess alternative forms of genomic communication and telehealth service delivery models with families from medically underserved populations.

Methods
We aim to enroll 496 participants between 0 and 21 years old to receive clinical genome sequencing. These individuals have a neurologic, cardiovascular, and/or immunologic disease. Participants will be English- or Spanish-speaking and predominantly from underrepresented groups who receive care in the New York metropolitan area. Prior to enrollment, participants will be randomized to either genetic counseling via videoconferencing with screen-sharing or genetic counseling via videoconferencing without screen-sharing. Using surveys administered at baseline, results disclosure, and 6-months post-results disclosure, we will evaluate the impact of the use of screen-sharing on participant understanding, satisfaction, and uptake of medical recommendations, as well as the psychological and socioeconomic implications of obtaining genome sequencing. Clinical utility, cost, and diagnostic yield of genome sequencing will also be assessed.

Discussion
The TeleKidSeq pilot study will contribute to innovations in communicating genomic test results to diverse populations through telehealth technology. In conjunction with NYCKidSeq, this work will inform best practices for the implementation of genomic medicine in diverse, English- and Spanish-speaking populations.
‘Get Healthy!’ physical activity and healthy eating intervention for adults with intellectual disability: results from the feasibility pilot
Authors: Salomon Carmela , Bellamy Jessica , Evans Elizabeth , Reid Renae , Hsu Michelle , Teasdale Scott , Trollor Julian 
Published: March 2023

AbstractBackgroundPeople with intellectual disabilities (ID) experience high rates of lifestyle related morbidities, in part due to lack of access to tailored health promotion programmes. This study aimed to assess the feasibility and preliminary efficacy of a tailored healthy lifestyle intervention,Get Healthy!MethodsGet Healthy!is a 12-week physical activity and healthy eating programme designed to address lifestyle-related risks for adults with mild-moderate ID. The feasibility pilot was designed to assess subjective participant experience and programme feasibility across: recruitment and screening, retention, session attendance and engagement, adverse events, and practicality and reliability of outcome procedures. Exploratory programme efficacy was assessed across the following measures: anthropometry (body mass index, weight, waist circumference), cardiovascular fitness, physical strength, dietary intake, healthy literacy, and quality of life.ResultsSix participants with moderate ID and two carer participants completed the feasibility trial, representing a 100% retention rate. Qualitative data indicated the programme was well received. Participants with ID attended 75% of sessions offered and displayed a high level of engagement in sessions attended (91% mean engagement score). While most data collection procedures were feasible to implement, several measures were either not feasible for our participants, or required a higher level of support to implement than was provided in the existing trial protocol. Participants with ID displayed decreases in mean waist circumference between baseline and endpoint (95% CI: − 3.20, − 0.17 cm) and some improvements in measures of cardiovascular fitness and physical strength. No changes in weight, body mass index, or objectively measured knowledge of nutrition and exercise or quality of life were detected from baseline to programme endpoint. Dietary intake results were mixed.DiscussionTheGet Healthy!programme was feasible to implement and well received by participants with moderate ID and their carers. Exploratory efficacy data indicates the programme has potential to positively impact important cardiometabolic risk factors such as waist circumference, cardiovascular fitness, and physical strength. Several of the proposed data collection instruments will require modification or replacement prior to use in a sufficiently powered efficacy trial.Trial registrationACTRN: ACTRN12618000349246. Registered March 8th 2018—retrospectively registered,https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=374497UTN: U1111-1209–3132.
Snacktivity™ to promote physical activity and reduce future risk of disease in the population: protocol for a feasibility randomised controlled trial and nested qualitative study
Authors: Daley Amanda J. , Griffin Ryan A. , Moakes Catherine A. , Sanders James P. , Skrybant Magdalena , Ives Natalie , Maylor Ben , Greenfield Sheila M. , Gokal Kajal , Parretti Helen M. , Biddle Stuart J. H. , Greaves Colin , Maddison Ralph , Mutrie Nanette , Esliger Dale W. , Sherar Lauren , Edwardson Charlotte L. , Yates Tom , Frew Emma , Tearne Sarah , Jolly Kate 
Published: March 2023

Abstract
Background
Many people do not regularly participate in physical activity, which may negatively impact their health. Current physical activity guidelines are focused on promoting weekly accumulation of at least 150 min of moderate to vigorous intensity physical activity (MVPA). Whilst revised guidance now recognises the importance of making small changes to physical activity behaviour, guidance still focuses on adults needing to achieve at least 150 min of MVPA per week. An alternative ‘whole day’ approach that could motivate the public to be more physically active, is a concept called Snacktivity™. Instead of focusing on achieving 150 min per week of physical activity, for example 30 min of MVPA over 5 days, Snacktivity™ encourages the public to achieve this through small, but frequent, 2–5 min ‘snacks’ of MVPA throughout the whole day.

Methods
The primary aim is to undertake a feasibility trial with nested qualitative interviews to assess the feasibility and acceptability of the Snacktivity™ intervention to inform the design of a subsequent phase III randomised trial. A two-arm randomised controlled feasibility trial aiming to recruit 80 inactive adults will be conducted. Recruitment will be from health and community settings and social media. Participants will be individually randomised (1:1 ratio) to receive either the Snacktivity™ intervention or usual care. The intervention will last 12 weeks with assessment of outcomes completed before and after the intervention in all participants. We are interested in whether the Snacktivity™ trial is appealing to participants (assessed by the recruitment rate) and if the Snacktivity™ intervention and trial methods are acceptable to participants (assessed by Snacktivity™/physical activity adherence and retention rates). The intervention will be delivered by health care providers within health care consultations or by researchers. Participants’ experiences of the trial and intervention, and health care providers’ views of delivering the intervention within health consultations will be explored.

Discussion
The development of physical activity interventions that can be delivered at scale are needed. The findings from this study will inform the viability and design of a phase III trial to assess the effectiveness and cost-effectiveness of Snacktivity™ to increase physical activity.

Trial registration
ISRCTN: 64851242.
Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation
Authors: Sun Avery Rui , Sun Qili , Wang Yansong , Hu Liqiu , Wu Yutong , Ma Fenbo , Liu Jiayi , Pang Xiangchao , Tang Bin 
Published: March 2023

Abstract

Background
Titanium (Ti) is now widely used as implant material due to its excellent mechanical properties and superior biocompatibilities, while its inert bioactivities might lead to insufficient osseointegration, and limit its performance in dental applications.

Methods

We introduced a robust and simple approach of modifying titanium surfaces with polysaccharide complexes. Titanium samples were subjected to hydrothermal treatment to create a uniform porous structure on the surface, followed by coating with a bioinspired and self-assembly polydopamine layer. Strontium
Eucommia Ulmoides
Polysaccharide (EUP-Sr) complexes are then introduced to the polydopamine-coated porous titanium. Multiple morphological and physiochemical characterizations are employed for material evaluation, while cell proliferation and gene expression tests using macrophages, primary alveolar bone osteoblasts, and vascular endothelial cells are used to provide an overall insight into the functions of the product. The significances of statistical differences were analyzed using student’s t-test.

Results

Microscopic and spectrometric characterizations confirmed that the Ti surface formed a porous structure with an adequate amount of EUP-Sr loading. The attachment was attributed to hydrogen bonding between the ubiquitous glycosidic linkage of the polysaccharide complex and the ring structure of polydopamine, yet the loaded EUP-Sr complex can be gradually released, consequently benefiting the neighboring microenvironment. Cell experiments showed no cytotoxicity of the material, and the product showed promising anti-inflammation, osseointegration, and angiogenesis properties, which were further confirmed by
in vivo
evaluations.

Conclusion
We believe the EUP-Sr modified titanium implant is a promising candidate to be used in dental applications with notable osteoimmunomodulation and angiogenesis functions. And the novel technique proposed in this study would benefit the modification of metal/inorganic surfaces with polysaccharides for future research.
Comparison of bird assemblage structures and diversity patterns between seasons among two Ethiopian wetlands
Authors: Awash Numeri , Tekalign Wondimagegnehu 
Published: March 2023

AbstractWetlands are significant habitats for bird populations, and knowledge of the diversity and other ecological aspects of bird species contribute to the management of the ecosystem. The present study was based on comparative studies of the diversity and relative abundance of bird species in the two wetlands of southwest Ethiopia. The point count method was utilized in this study. For the data analysis, the Shannon–Weaver diversity index, independent sample t-test, and similarity index were employed. A total of 36 bird species under 11 orders and 24 families were identified. The species diversity and relative abundance were higher in both wetlands during the wet season. The Loga wetland had the higher diversity (H’ = 3.089), whereas the lowest species diversity (H’ = 2.643) was recorded in the wetland of Hurri. During the dry season, the Loga wetland (H’ = 2.738) and the Hurri habitat (H’ = 2.283) had higher and lower diversity, respectively. Seasonal variations in bird species diversity are not statistically significant (p > 0.05). Although the two wetlands support several water birds, they have received no conservation attention from concerned bodies. Further follow-up studies over a long period will help determine species-specific conservation measures for wetland-dependent birds.
A multidimensional review of the cash management problem
Authors: Salas-Molina Francisco , Rodríguez-Aguilar Juan A. , Guillen Montserrat 
Published: March 2023

AbstractIn this paper, we summarize and analyze the relevant research on the cash management problem appearing in the literature. First, we identify the main dimensions of the cash management problem. Next, we review the most relevant contributions in this field and present a multidimensional analysis of these contributions, according to the dimensions of the problem. From this analysis, several open research questions are highlighted.
Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types
Authors: Kim Hack-Lyoung , Chung Jaehoon , Han Seokmoon , Joh Hyun Sung , Lim Woo-Hyun , Seo Jae-Bin , Kim Sang-Hyun , Zo Joo-Hee , Kim Myung-A 
Published: March 2023

Abstract
Background
Little is known about the characteristics of arterial stiffness in heart failure (HF). This study was performed to compare the degree of arterial stiffness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF).

Methods
A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All HF patients had a history of hospitalization for HF treatment. Brachial-ankle pulse wave velocity (baPWV) measurement and transthoracic echocardiography were performed at the same day in a stable condition.

Results
The baPWV was significantly higher in patients with both HFrEF and HFpEF compared to control subjects (1,661 ± 390, 1,909 ± 466, and 1,477 ± 296 cm/sec, respectively; P < 0.05 for each). After adjustment of age, baPWV values were similar between patients with HFrEF and HFpEF (P = 0.948). In the multiple linear regression analysis, baPWV was significantly associated with both septal e′ velocity (β = –0.360, P = 0.001) and E/e′ (β = 0.344, P = 0.001). However, baPWV was not associated with either of the diastolic indices in HFrEF group. The baPWV was associated only with septal e′ velocity (β = –0.429, P = 0.002) but not with E/e′ in the HFpEF group in the same multivariable analysis.

Conclusions
Although arterial stiffness was increased, its association with LV diastolic function was attenuated in HF patients compared to control subjects. The degree of arterial stiffening was similar between HFrEF and HFpEF.
Patient engagement in a national research network: barriers, facilitators, and impacts
Authors: Gonzalez Miriam , Ogourtsova Tatiana , Zerbo Alix , Lalonde Corinne , Spurway Amy , Gavin Frank , Shikako Keiko , Weiss Jonathan A. , Majnemer Annette 
Published: March 2023

Abstract
Background
Little is known about patient engagement in the context of large teams or networks. Quantitative data from a larger sample of CHILD-BRIGHT Network members suggest that patient engagement was beneficial and meaningful. To extend our understanding of the barriers, facilitators, and impacts identified by patient-partners and researchers, we conducted this qualitative study.

Methods
Participants completed semi-structured interviews and were recruited from the CHILD-BRIGHT Research Network. A patient-oriented research (POR) approach informed by the SPOR Framework guided the study. The Guidance for Reporting Involvement of Patients and the Public (GRIPP2-SF) was used to report on involvement of patient-partners. The data were analyzed using a qualitative, content analysis approach.

Results
Twenty-five CHILD-BRIGHT Network members (48% patient-partners, 52% researchers) were interviewed on their engagement experiences in the Network’s research projects and in network-wide activities. At the research project level, patient-partners and researchers reported similar barriers and facilitators to engagement. Barriers included communication challenges, factors specific to patient-partners, difficulty maintaining engagement over time, and difficulty achieving genuine collaboration. Facilitators included communication (e.g., open communication), factors specific to patient-partners (e.g., motivation), and factors such as respect and trust. At the Network level, patient-partners and researchers indicated that time constraints and asking too much of patient-partners were barriers to engagement. Both patient-partners and researchers indicated that communication (e.g., regular contacts) facilitated their engagement in the Network. Patient-partners also reported that researchers’ characteristics (e.g., openness to feedback) and having a role within the Network facilitated their engagement. Researchers related that providing a variety of activities and establishing meaningful collaborations served as facilitators. In terms of impacts, study participants indicated that POR allowed for: (1) projects to be better aligned with patient-partners’ priorities, (2) collaboration among researchers, patient-partners and families, (3) knowledge translation informed by patient-partner input, and (4) learning opportunities.

Conclusion
Our findings provide evidence of the positive impacts of patient engagement and highlight factors that are important to consider in supporting engagement in large research teams or networks. Based on these findings and in collaboration with patient-partners, we have identified strategies for enhancing authentic engagement of patient-partners in these contexts.
Rationale and design of a cardiac safety study for reduced cardiotoxicity surveillance during HER2-targeted therapy
Authors: Yu Anthony F. , Dang Chau T. , Jorgensen Justine , Moskowitz Chaya S. , DeFusco Patricia , Oligino Eric , Oeffinger Kevin C. , Liu Jennifer E. , Steingart Richard M. 
Published: March 2023

Abstract
Background
Echocardiograms are recommended every 3 months in patients receiving human epidermal growth factor 2 (HER2)-targeted therapy for surveillance of left ventricular ejection fraction (LVEF). Efforts to tailor treatment for HER2-positive breast cancer have led to greater use of non-anthracycline regimens that are associated with lower cardiotoxicity risk, raising into question the need for frequent cardiotoxicity surveillance for these patients. This study seeks to evaluate whether less frequent cardiotoxicity surveillance (every 6 months) is safe for patients receiving a non-anthracycline HER2-targeted treatment regimen.

Methods/design
We will enroll 190 women with histologically confirmed HER2-positive breast cancer scheduled to receive a non-anthracycline HER2-targeted treatment regimen for a minimum of 12 months. All participants will undergo echocardiograms before and 6-, 12-, and 18-months after initiation of HER2-targeted treatment. The primary composite outcome is symptomatic heart failure (New York Heart Association class III or IV) or death from cardiovascular causes. Secondary outcomes include: 1) echocardiographic indices of left ventricular systolic function; 2) incidence of cardiotoxicity, defined by a ≥ 10% absolute reduction in left ventricular ejection fraction (LVEF) from baseline to < 53%; and 3) incidence of early interruption of HER2-targeted therapy.

Conclusions
To our knowledge, this will be the first prospective study of a risk-based approach to cardiotoxicity surveillance. We expect findings from this study will inform the development of updated clinical practice guidelines to improve cardiotoxicity surveillance practices during HER2-positive breast cancer treatment.

Trial registration
The trial was registered in the ClinicalTrials.gov registry (identifier NCT03983382) on June 12, 2019.
Acute hypoxemia due to right-to-left shunt via a patent foramen ovale during left internal thoracic artery to left anterior descending artery anastomosis in off-pump coronary artery bypass grafting: a case report
Authors: Okutomi Yuki , Sajima Takeyuki , Yasuda Atsushi , Sawamura Shigehito 
Published: March 2023

Abstract
Background
A right-to-left shunt via a patent foramen ovale (PFO) during off-pump coronary artery bypass (OPCAB) may result in difficulties in oxygenation and circulatory management. We herein present a case of a marked shunt via a PFO during OPCAB.

Case presentation
A 74-year-old man who had aortic root enlargement, compressing the right atrium, and an atrial septal aneurysm, underwent OPCAB. When the heart was fixed for the anastomosis of the left anterior descending artery, sudden hypoxemia and hypotension were observed. Intraoperative transesophageal echocardiography (TEE) showed a right-to-left shunt via a PFO that was unnoticed preoperatively. After the anastomosis was completed, TEE revealed no shunt through the PFO.

Conclusions
We should check for a PFO in case of an atrial septal aneurysm. Compression of the right atrium is considered an important anatomical risk of the right-to-left shunt in OPCAB.
The stagnation of innovation in humanitarian cash assistance
Authors: Monich Alex , Holm-Nielsen Pablo V. , Raju Emmanuel 
Published: March 2023

AbstractCash and voucher assistance (CVA) has been gaining traction among humanitarian organizations as the preferred aid modality in disaster relief and complex emergencies. While the advantages of cash are well documented, the ongoing digitalization of cash and the emergence of innovative financial instruments can be associated with new operational challenges and a stagnation in innovation.This paper reflects on the changing environment in CVA as a result of technological breakthroughs in the global financial system. The concept of humanitarian innovation is introduced to differentiate it from a similar process in the private sector and to investigate factors, contributing to a slower pace of acceptance, a reluctant implementation, or a complete rejection of innovative approaches in the humanitarian organization. The purpose of the study is to conceptualize the challenges of new technology adoption and scaling, as well as to analyze the direction and current stage of the diffusion of innovation in the humanitarian sphere.Ten interviews with informants representing humanitarian agencies and the private sector were conducted to discuss their experiences with new CVA tools and perspectives on innovation in cash and voucher assistance. The results demonstrate that there is no uniform perception of innovation across the field, and the challenges of diffusion can be associated with several domains, including internal and external capacities, inherent characteristics of new financial technology (fintech), and a wider social, political, and regulatory context. According to the cyclical model of technological change, the innovative CVA fintech is currently at the ferment stage characterized by a high level of uncertainty and competition. The subsequent emergence of several dominant designs followed by incremental innovation is plausible in the future.