bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNP Markers Revealing the uniqueness of Gushan semi-rock tea in the tea germplasm resources of Fujian, China
Authors: Wang Pan , Lv Shuiyuan , Yu Wentao , Lin Cheng , Zhu Yanyu , Gui Wenjing , Liu Caiguo , Ye Naixing 
Published: June 2023

Abstract
As a renowned tea with a historical significance in China, Gushan semi-rock tea originated from the Gushan Mountain in Fujian, China. This study describes the genetic diversity, population structure, and distribution characteristics of 76 tea samples collected from Gushan Mountain and neighboring regions, using single nucleotide polymorphism (SNP) markers. The results show that the average information index (I) is 0.490, the average observed heterozygosity (Ho) is 0.384, the average expected heterozygosity (He) is 0.329, and the average fixation index (F) is -0.132. The genetic variation mainly comes from intraregional variation, which accounts for 82% of the total variation. Furthermore, there is a closer connection between tea plants in Southern, Northern, and Eastern Fujian. The frequency of genetic exchange between tea plants in the Gushan semi-rock tea and those in Southern, Northern, and Eastern Fujian is relatively low, showing obvious uniqueness. The findings of this study help fill the gap in tea genome research in the Gushan semi-rock tea and provide valuable information on the genetic diversity of tea resources in Gushan area. The results can be utilized in future genomics, phylogeny, and artificial breeding programs aimed at developing new tea varieties.
Excitation of tunable dual quasi-bound states in the continuum in graphene metasurface and terahertz sensing application
Authors: Huang Zhong , Chen Qing , Cao Xiaoxiao , Ding Ji , Tang Chaojun , Yan Zhendong , Chen Jing 
Published: June 2023

Abstract

This study proposes an all-graphene metasurface supporting dual band symmetric bound state in the continuum (BIC) in the terahertz (THz) range for the first time. The structure consists of a unit cell containing a double-gap split ring resonator periodically on a dielectric substrate. By introducing symmetry breaking, two plasmonic quasi-BICs (Q-BICs) transmission dips are observed with finite Q-factors and high modulation depth. Simulation and analysis results simultaneously exhibit that the Q-factors of Q-BICs follow an inverse square dependency with the asymmetry degree. Via changing the graphene’s chemical potential, the Q-BICs’ operating frequency range can be actively expanded. The dual Q-BICs are immune to the variation of incident angle and has a significant slow light effect with time delay up to 23.8 ps. In addition, the sensing performance in THz region is investigated. A maximum sensitivity of 267.5 GHz/RIU is obtained with a FOM of 24.08 RIU− 1. Our work shows an alternative way to design the class of tunable Q-BIC metasurface, which will provide a valuable reference for future dynamic sensor and other fields.
Optimizing the Cumulative Cisplatin Dose for Concurrent Chemoradiotherapy Beneficiaries Among Elderly Nasopharyngeal Carcinoma Patients: A Real World Study
Authors: Wu Yan-Ling , He Shuiqing , He Danjie , Gao Yongxiang , Huang Ying , Jin Jing 
Published: June 2023

Abstract

Objective
This study aimed to find a safe and effective cumulative cisplatin dose (CCD) for concurrent chemoradiotherapy (CCRT) beneficiaries among elderly nasopharyngeal carcinoma (NPC) patients.
Materials and methods
A total of 765 elderly (≥ 60 years old) NPC patients treated with cisplatin-based CCRT and IMRT-alone from 2007 to 2018 were included in this study. RPA-generated risk stratification was used to identify CCRT beneficiaries. CCDs were divided into CCD = 0, 0 < CCD ≤ 80, 80 < CCD ≤ 160 and 160 < CCD ≤ 300 mg/m2 and their OS and nephrotoxicity compared.
Results
Pre-treatment plasma EBV DNA and clinical Stage were incorporated into the RPA model to perform risk stratification. All patients were classified into either a high-risk group (n = 158, Stage IV), an intermediate-risk group (n = 193, EBV DNA > 2000 copy/mL & Stage I, II, III) or a low-risk group (n = 414, EBV DNA ≤ 2000 copy/mL & Stage I, II, III). The 5-yearOS of CCRT vs. IMRT alone in the high-, intermediate- and low-risk groups after balancing covariate bias were 60.1% vs 46.6% (p = 0.02), 77.8% vs 64.6% (p = 0.03) and 86.2% vs 85.0% (p = 0.81), respectively. The 5-year OS of patients receiving CCD = 0, 0 < CCD ≤ 80, 80 < CCD ≤ 160 and 160 < CCD ≤ 300 mg/m2 after balancing covariate bias in the high-risk group were 45.2%, 48.9%, 73.4% and 58.3% (p = 0.029), in the intermediate-risk group they were 64.6%, 65.2%, 76.8% and 83.6% (p = 0.038), and in the low-risk group they were 85.0%, 68.1%, 84.8% and 94.0% (p = 0.029), respectively. In the low-risk group, the 5-year OS of Stage III patients receiving CCD = 0, 0 < CCD ≤ 80, 80 < CCD ≤ 160 and 160 < CCD ≤ 300 mg/m2 were 83.5%, 76.9%, 85.5% and 95.5% (p = 0.044), respectively. No Grade 3–4 nephrotoxicity occurred.
Conclusions
In our study, Stage I, II & EBV DNA > 2000copy/ml and Stage III, IV elderly NPC patients may be CCRT beneficiaries. 80 < CCD ≤ 300 mg/m2 is recommended for the high-risk (Stage IV) group, and 160 < CCD ≤ 300 mg/m2 for the intermediate-risk (Stage I, II, III & EBV DNA > 2000copy/ml) and low-risk (Stage III&EBV DNA ≤ 2000 copy/ml) groups. No Grade 3–4 nephrotoxicity occurred in any of the CCD groups.
Identification of Ferroptosis-related genes in sepsis-induced acute respiratory distress syndrome
Authors: Zhang Xiao , Ma Yuan , Qin Weiwei , Dai Yuting , Ma Fuguo , Sun Lixin 
Published: June 2023

AbstractObjective:The objective of this investigation was to examine the association between genes related to ferroptosis (FAGs) and acute respiratory distress syndrome (ARDS) induced by sepsis in individuals.Methods:Microarray profiles (GSE332707) from the GEO database were utilized to screen for differential genes. FAGs were derived from three gene pools (KEGG database, NCBI, FerrDb database). The co-expression genes were obtained through the intersection of differential genes (DEGs) in GSE332707 and FAGs. Subsequently, hub genes were discerned by means of GO, KEGG, and PPI network analysis. The validation of these hub genes was carried out experimentally using the RT-qPCR technique and a separate dataset (GSE66890). Ultimately, target gene prediction was conducted through the utilization of GeneCard and StarBase 3.0.Results:A total of 565 DEGs were identified between sepsis-induced ARDS and control samples, with 30 co-differential genes being detected. Then, the protein interaction network of 30 co-differential genes unearthed 5 hub genes (CTSB, LCN2, ZFP36, KLF2, and IRF1). Validation of the 5 hub genes was performed using RT-qPCR and GSE66890, which confirmed LCN2 as a potential prognostic candidate gene. The hsa-miR-374b-3p emerged as the most strongly supported candidate miRNA of LCN2.Conclusion:Based on our findings, we conclude that LCN2, a potential biomarker associated with FAGs, may play a role in the pathogenesis of sepsis-induced ARDS.
Broad Protection Against Clade 1 Sarbecoviruses After a Single Immunization with Cocktail Spike-Protein-Nanoparticle Vaccine
Authors: Kane Ravi , Halfmann Peter , Loeffler Kathryn , Duffy Augustine , Kuroda Makoto , Kawaoka Yoshihiro 
Published: June 2023

Abstract
The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the need for a broadly protective vaccine against ACE2-utilizing sarbecoviruses. While updated variant-matched formulations such as Pfizer-BioNTech’s bivalent vaccine are a step in the right direction, protection needs to extend beyond SARS-CoV-2 and its variants to include SARS-like viruses. Here, we introduce bivalent and trivalent vaccine formulations using our spike protein nanoparticle platform that completely protected hamsters against BA.5 and XBB.1 challenges with no detectable virus in the lungs. The trivalent cocktails elicited highly neutralizing responses against all tested Omicron variants and the bat sarbecoviruses SHC014 and WIV1. Finally, our 614D/SHC014/XBB trivalent spike formulation completely protected human ACE2-transgenic hamsters against challenges with WIV1 and SHC014 with no detectable virus in the lungs. Collectively, these results illustrate that our trivalent protein-nanoparticle cocktail can provide broad protection against SARS-CoV-2-like and SARS-CoV-1-like sarbecoviruses.
Public Perception Towards Children's COVID-19 Vaccination with Natural Language Processing
Authors: DELİCE Elif , TOZAN Hakan , POLATLI L. Özge , KARADAYI Melis A. 
Published: June 2023

Abstract
In 2019, Coronavirus manifested itself in China and caused numerous deaths. Vaccines developed against COVID-19 are seen as a way to end or mitigate the pandemic. Many debates arose about the vaccination of children through social media. The main target of this study is to present a model that reveals the perception of parents about getting their children vaccinated, extracts the main themes, and determines the emotional changes. With the support of the Octoparse web scraping tool, data was extracted from Twitter when the epidemic turned into a global problem and the discussions about vaccines intensified. Then, using the topic modeling and sentiment analysis techniques under the umbrella of (Natural Language Processing) NLP, main, sub-topics about parents' attitudes were revealed, also vaccine perceptions were detected by performing sentiment analysis. As a result, four topic clusters were determined: “the opinion of the need for the first dose of vaccination according to age”, “the effectiveness of the first dose of vaccine”, “the opinion of the need for vaccination of school-age children”, and “the need for vaccination arising from the protection of unvaccinated children with only mask protection”. With sentiment analysis, it was seen that positive emotions were dominant, and three emotions, namely trust, expectation, and fear, came to the fore. In conclusion, it has been determined that families trust the states and their announcements about getting their children vaccinated, they anticipate new vaccines to be developed, but they are also afraid of the risks that the vaccine will bring to their children.
Infinite disorder renormalization fixed point for the continuum random field Ising chain
Authors: Collin Orphée , Giacomin Giambattista , Hu Yueyun 
Published: June 2023

Abstract

We consider the continuum version of the random field Ising model in one dimension: this model arises naturally as weak disorder scaling limit of the original Ising model. Like for the Ising model, a spin configuration is conveniently described as a sequence of spin domains with alternating signs (domain-wall structure). We show that for fixed centered external field and as spin-spin couplings become large, the domain-wall structure scales to a disorder dependent limit that coincides with the infinite disorder fixed point process introduced by D. S. Fisher in the context of zero temperature quantum Ising chains. In particular, our results establish a number of predictions that one can find in [Fisher, Le Doussal and Monthus 2001]. The infinite disorder fixed point process for centered external field is equivalently described in terms of the process of suitably selected extrema of a Brownian trajectory introduced and studied by J. Neveu and J. Pitman [Neveu and Pitman 1989]. This characterization of the infinite disorder fixed point is one of the important ingredients of our analysis.
AMS subject classification (2010 MSC): 60K37, 82B44, 60J70, 82B28
The Effect of Prenatal Rooming-In Shared Decision-Making on Postpartum Exclusive Breastfeeding in Taiwan
Authors: Hung Hsiao-Ying , Wen Chun-Che , Su Pei-Fang , Chang Ying-Ju 
Published: June 2023

AbstractBackground 24-hour rooming-in is a crucial policy in BFHI for promoting breastfeeding. However, Taiwan’s BFHI certification included prenatal shared decision-making (SDM) for rooming-in until 2018. Prior to this update, maternal rooming-in intentions, related factors to the prenatal SDM decision, and the impact of prenatal SDM implementation on postpartum exclusive breastfeeding were unknown. Methods A retrospective medical review study was conducted. Describe statistics, nonparametric tests, and generalized-estimating equation (GEE) were used. Results Women's comprehension of rooming-in was inadequate compared to breastfeeding. Women who were older, worked full-time, had a graduate degree, and believed that rooming-in interrupted their rest weakened their prenatal rooming-in intention. In GEE, only age (OR = 0.92, 95% CI: [0.89 − 0.97],p = 0.001), primiparity (OR = 0.50. 95% CI: [0.32, 0.78],p = 0.002), vaginal delivery (OR = 1.52, 95% CI: [1.001, 2.33],p = 0.049), and prenatal exclusive breastfeeding intention (OR = 3.33, 95% CI: [2.08, 5.33],p < .001) were related to postpartum exclusive breastfeeding, not prenatal rooming-in intention. Conclusion Prenatal SDM ensures autonomy for women and their families with respect to
Vaginal colonization with virulent Staphylococcus aureus and methicillin resistant Staphylococcus aureus among Ugandan women in labour
Authors: Bwanga Freddie , Mukashyaka Claudine , Kateete David Patrick , Tumuhamye Josephine , Okeng Alfred , Aboce Emmanuel , Namugga Olive , Kwizera Richard , Sommerfelt Halvor , Nankabirwa Victoria 
Published: June 2023

Abstract

Background Staphylococcus aureus (S. aureus) often colonizes the human skin, upper respiratory and genital tracts. In the female genital tract, it can be passed on to the newborn during vaginal delivery leading to either ordinary colonization, or neonatal infections notably umbilical stump sepsis, scalded skin syndrome, arthritis, or bactereamia/sepsis. These infections are mediated by Staphylococcal virulence factors such as i. Staphylococcal Enterotoxins A, B, C, D, and E encoded by the sea, seb, sec, sed, see genes, ii. Exfoliative Toxins A and B encoded by the eta and etb genes, iii. Toxic Shock Syndrome Toxin 1 (TSST-1) encoded by the tst gene, iv. Panton-Valentine Leukocidin (PVL) encoded by the pvl gene, and v. Hemolysins alpha and delta encoded by the hla and hld genes, respectively. We determined the prevalence of S. aureus possessing one or more virulence factor genes and of methicillin resistant Staphylococcus aureus (MRSA) in this population.Methods This was a descriptive cross-sectional study, which used 85 retrieved cryopreserved S. aureus isolates from the Chlorohexidine (CHX) clinical trial in Uganda. The isolates had been obtained by culturing vaginal swabs (VS) from 1472 women in labour. Isolates were thawed and sub-cultured. These were studied for selected virulence and methicillin resistance genes (mecA) using molecular techniques. Data were analysed using SPSS version 20.Results Of the 85 S. aureus isolates 13 (15.3%) were positive for one or more virulence factor genes, as follows: pvl 9/85 (10.6%), hld 5/85 (5.9%), sea 1/85 (1.2%) and seb genes 1/85 (1.2%). The other virulence genes (sec, sed, see, eta, etb, hla and tst) were not detected in any of the isolates. MRSA was detected in 55.3% (47/85) of the isolates, but only two of these carried the pvl virulence gene.Conclusion This study demonstrated that 15% of the S. aureus colonizing the female lower genital tract of mothers in labour in central Uganda carried one or more virulence genes, mostly pvl. More than half of the isolates were MRSA but mostly avirulent. Therefore, in the study settings, the potential for newborn infection with virulent S. aureus stands, but with non-MRSA strains.
Seasonal patterns in trace elements assessed in toenails
Authors: Wojcik Kaitlyn M. , Von Holle Ann , O’Brien Katie M. , White Alexandra J. , Karagas Margaret R. , Levine Keith E. , Jackson Brian P. , Weinberg Clarice R. 
Published: June 2023

Abstract

Seasonal patterns in measured exposure biomarkers can cause measurement error in epidemiological studies. There is little known about the seasonality of trace elements when measured in toenails. Adjusting for such patterns when estimating associations between long-term exposures and health outcomes could be needed to improve precision and reduce bias. Our goal was to assess seasonal patterns in toenail measurements of trace elements. At enrollment, Sister Study participants, who were US residents, removed polish and collected toenail clippings, which were cleaned before analysis. We measured: iron, vanadium, aluminum, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, cadmium, tin, antimony, mercury, and lead. For a sample of the cohort we fit trigonometric regression models with toenail element measures as the outcome, using sine and cosine functions of the collection day of the year (transformed to an angle) to assess seasonality. Results were replicated in a second sample of women, with measurements done in a separate lab. There was a seasonal association between day of collection and toenail measures for iron, aluminum, vanadium, chromium, manganese, cobalt, arsenic, molybdenum, cadmium, tin, and lead, all of which peaked near mid-August. Seasonal patterns were concordant across the two samples of women. Given the evidence supporting seasonal patterns for 11 of the 17 elements measured in toenails, correcting for seasonality of toenail levels of those trace elements in models estimating the association between those exposures and health outcomes is important. The basis for higher concentrations in toenails collected during the summer remains unknown.
Effect of the particle geometry on lightweight particleboards from Paulownia using high frequency pressing technology
Authors: Röllig Paul , Tudor Eugenia Mariana , Barbu Marius Cătălin , Direske Martin 
Published: June 2023

Abstract

The aim of this research is to manufacture lightweight single-layered particleboard made of paulownia plantation wood and to analyse to what extend the panel´s properties are influenced by particle geometry. Panels with a thickness of 16 mm and two levels of density, 300 and 400 kg/m³ were manufactured with urea-formaldehyde adhesive using high-frequency (HF) pressing technology. The entire production process, from stem debarking up to particleboard manufacturing was described and assessed. The physical and mechanical properties of the panels met at least the requirement for LP1 (light)particleboards for general purposes and use in dry conditions. A higher particle size determined increased bending properties and better internal bond, but also more affinity to water absorption. As a product that withstands the criteria for at least LP1 classification, the particleboards made of paulownia manufactured with HF technology are innovative sustainable products for the furniture industry.
Enhancing the Static and Dynamic Parameters in Asymmetrical Multilevel Inverter fed Induction Motor Drive operated at Low Switching Frequency
Authors: Karunanidhi Venkataramanan , Subramanian Vasantharaj , Ramilingam Balamurugan Chinnapettai 
Published: June 2023

Abstract
This article describes how to build a solar photovoltaic-fed multilevel inverter with a low switch count to power an induction motor. The proposed system consists of a photovoltaic (PV) panel, an Asymmetrical Multi-Level Inverter (AMLI), and an induction motor drive. The proposed AMLI is made up of two DC sources, which are powered by PV panels. The main advantage of this method is that it does not require an auxiliary circuit to generate negative levels. The MATLAB/ Simulink model is used to investigate an AMLI using a Dual Carrier Multi Reference PWM (DCMRPWM) technique for renewable energy applications. Likewise, the proposed work includes an adaptive fuzzy logic-based closed-loop control solution for faster induction machine settling time, higher system efficiency, and reduction in total harmonic distortion (THD) without the use of a filter circuit. The findings indicate that the proposed control system is effective at reducing losses and increasing system efficiency. The system's performance is also compared to that of the standard PI controller. Similarly, this paper proposes an optimal switching strategy for reducing torque ripples in an induction motor drive.
Systemic immune inflammation index is associated with ulcerative plaque in patients with acute ischemic stroke: A single center exploratory study
Authors: Zhang Lianlian , Xu Xinchun , Zhang Xinyuan , Jiang Shu , Hui Pinjing 
Published: June 2023

Abstract
Purpose
This study explored the correlation between inflammatory markers and ulcerative plaques based on Carotid Doppler Ultrasound (CDU) in individuals with Acute Ischemic Stroke (AIS).
Methods
A total of 202 cases diagnosed with AIS associated with atherosclerotic plaque (AP) in the carotid artery were enrolled in this research. CDU was used to assess carotid atherosclerotic vulnerability and vulnerability-related component features. The AP was classified into different types based on symmetric features and location. Logistic regression and receiver operating characteristic (ROC) curve were employed to analyze the correlation between inflammatory indexes, the shape and position of AP, the degree of carotid artery stenosis, and the presence of ulcerative plaques. Cut-off values were determined accordingly.
Results
The Systemic Immune Inflammation index (SII) and high sensitivity CRP (hs-CRP) were independent risk factors for the formation of vulnerable carotid plaques. SII level, type A plaque, plaque above carotid bifurcation, and severe carotid stenosis were independent risk factors for ulcerative plaque. The AUC value of SII in predicting ulcerative plaque was 0.895, the sensitivity, specificity, the best cut-off value was 93.3%, 89.2%, 537.4(109/L), respectively.
Conclusion
Elevated SII levels at admission were found to be independently associated with the presence of AIS with vulnerable plaque, especially ulcerative plaques. Moreover, plaque ulceration was more likely to form when the area of higher plaque thickness was located in the upstream arterial wall of maximum plaque thickness (WTmax), plaque was above the carotid bifurcation, and severe carotid stenosis, providing new insights into the formation of vulnerable plaques.
Sexual stimulation for distal ureteral stones: a meta-analysis
Authors: Peng Chengxia , Zhou Minghui , Wu Guanghao , Xu Li , Feng Chao , Ye Chunhua 
Published: June 2023

Abstract
Background
This article aimed to investigate the clinical efficiency of sexual stimulation in the treatment of distal ureteral stones.
Methods
We searched PubMed, Web of Science, Cochrane Library and Google Scholar from January 1, 2000 to December 31, 2022 for studies comparing sexual stimulus to placebo for the treatment of distal ureteral stones. RevMan 5.3 software was used to pool the data.
Results
A total of 6 randomized controlled trials (RCTs) comprising 535 cases of distal ureteral stones were included. 273 cases were associated with sexual intercourse or masturbation 3–4 times a week, and 262 cases received only conventional medical treatment. The pooled results showed that the 2-week [risk ratios (RR) = 1.77, 95% confidence interval (CI): 1.34, 2.33] and 4-week [RR = 1.48, 95% CI: 1.29, 1.69] expulsion rates of the sexual stimulation group were significantly higher than in the placebo group (ps<0.01). Additionally, sexual stimulation was associated with a shorter expulsion time [weight mean differences (WMD) = -3.74, 95% CI: -6.27, -1.22, p < 0.01] and a decreased prevalence of renal colic attacks [WMD = -0.61, 95% CI: -1.01, -0.22, p < 0.01].
Conclusions
Proper sexual stimulation can enhance the spontaneous expulsion of distal ureteral stones in patients presenting tolerable pain.