bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Markov network approach for reproducing purchase behaviours observed in convenience stores
Authors: Johansson Dan , Takayasu Misako , Takayasu Hideki 
Published: September 2023

Abstract

The convenience store industry in Japan holds immense significance, making a thorough comprehension of customer purchase behavior invaluable for companies aiming to gain insights into their customer base. In this paper, we propose a novel application of a Markov network model to simulate purchases which guided by stopping probabilities calculated from real data. Each node in the Markov network represents different product categories available for purchase. Additionally, we introduce the concept of a "driving force," quantifying the influence of purchasing product A on the likelihood of purchasing product B, compared to random purchasing. For instance, our analysis reveals that the inclusion of nutrient bars in a purchase set leads to, on average, a 13% reduction in tobacco purchases compared to random patterns. To validate our approach, we compare the simulated macro-level purchase behaviors with real Point of Sale (POS) data obtained from a prominent convenience store giant, 7-ELEVEN. The dataset is comprised off roughly 54 million receipts, in which we focus on the product categories existing in this dataset rather than individual products. Our model successfully replicates the purchase size distribution for 99.9% of all purchases and the purchase counts across various product categories, demonstrating its efficacy in capturing broad purchase patterns.
Prognostic analysis of hepatocellular carcinoma based on Cuproptosis - associated lncRNAs
Authors: Wei Weiming , Lu Libai , Luo Zongjiang , Ma Jiasheng , Wang Jianchu 
Published: September 2023

Abstract

Objectives
Cuproptosis is a novel form of copper-dependent non-apoptotic cell death, and the role of copper apoptosis-associated long non-coding RNAs (CRLncRNAs) in hepatocellular carcinoma (HCC) has not been elucidated. In this study, we aimed to investigate the significance of copper apoptosis-related lncRNAs in HCC in tumorigenesis and prognosis.
Methods
We analyzed gene transcriptomic data and clinical data of HCC cases by obtaining them from The Cancer Genome Atlas (TCGA). We combined Cuproptosis-related genes to establish prognostic Cuproptosis -related lncRNA features and further illustrated the mechanism of Cuproptosis-related LncRNAs in the prognosis and treatment of HCC through Lasso and Cox regression analyses, survival analyses of samples, and analyses of tumor mutation load as well as immune function。
Results
We established a prognosis-related model consisting of 6 Cuproptosis -related lncRNAs: AC026412.3, AC125437.1, AL353572.4, MKLN1-AS, TMCC1-AS1, SLC6A1-AS1. Both the training and validation sets had excellent results in the prognosis of tumor patients, and the survival time of the low-risk group based on the model was much higher than that of the high-risk group. Besides, the analysis of tumor mutation load difference, immune function analysis, GO/KEGG pathway enrichment analysis, and drug sensitivity analysis also demonstrated the possible mechanism of Cuproptosis-associated LncRNAs.
Conclusions
The model constructed based on Cuproptosis-related lncRNA has good predictions for the prognosis and immunotherapy of tumor patients, which may play an important role in patient management and immunotherapy, providing reference value for subsequent research.
Diagnostic Potential of MicroRNA-1, MicroRNA-21, and MicroRNA-29 as Novel Biomarkers for Early Development of Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction
Authors: Andrianto Andrianto , Al-Farabi Makhyan Jibril , Arifitrianto Muhammad Gani , Juwita Rahima Ratna , Firmansyah Okky Wahyu , Intan Ryan Enast , Fadila Asiyah Nurul , Tiyantara Muhammad Surya , Suryawan I Gde Rurus , Ardiana Meity , Rahmianti Nia Dyah , Pikir Budi Susetyo , Nugraha Ricardo Adrian 
Published: September 2023

Abstract

Background:
Currently, there is an unmet need for a minimally invasive diagnostic tool with less radiation for the early development of myocardial fibrosis and targeted treatment for preserved ejection fraction (HFpEF). This study aimed to investigate the diagnostic potential of circulating microRNAs (miRNAs) for detecting early myocardial fibrosis development in HFpEF patients.
Methods:
This observational study used a case-control research design. Peripheral blood samples were isolated from 25 HFpEF patients and 25 normal patients. They were measured for complete laboratory testing, NTproBNP levels using ELISA, as well as MicroRNA-1, 21, and 29 levels using RT-PCR. All patients also underwent echocardiography for global longitudinal strain (GLS) to measure the myocardial fibrosis progression. Data were analyzed using SPSS 25.0.
Results:
HFpEF patients had significantly higher GLS compared to the normal patients (-13±2.4% vs -19±3.2%; p < 0.05), suggesting HFpEF patients tended to have myocardial fibrosis. HFpEF patients also had significantly higher microRNA-1 and microRNA-21 compared to the normal patients (p < 0.05), but they had lower microRNA-1 (p < 0.05). There was a positive correlation between microRNA-1 (r = 0.753; p < 0.05) and microRNA-21 (r = 0.675; p < 0.05) and an inverse correlation with microRNA-29 (r = -0.653; p < 0.05) based on the GLS findings. By using a GLS cutoff of -15% for myocardial fibrosis, microRNA-1, microRNA-21, and microRNA-29 were found to be able to predict myocardial fibrosis based on GLS with a specificity of 78% and sensitivity of 75%.
Conclusion:
Increasing microRNA-1 and microRNA-21 followed by decreasing microRNA-29 in HFpEF patients suggest early myocardial fibrosis. Detection of those biomarkers can be beneficial for early myocardial fibrosis diagnosis, early aggressive HFpEF treatment, and targeted miRNA silencing therapy to prevent worsening HFpEF.
Anxiety and Depression Among Nigerian Undergraduates: a Cross- Sectional Study
Authors: Adeleke Olumide Thomas , Opadola Oluwafunbi , Ojo Modupe Mofoluke , Abiola Samuel-Ajayi Yetunde , Praise Nebechukwu , Adeleke Oludamola Victoria , Adedeji Afolabi Samson , Ayobami Taiwo Oladayo 
Published: September 2023

Abstract
Background
Globally, there is rising concern regarding the increased prevalence of mental disorders among university students, as studies have demonstrated a significant clinical measure of psychiatric morbidities among undergraduates worldwide. Sadly, there is a paucity of data on the burden of mental illness among undergraduates in Nigeria, and undergraduate students' mental health problems have not received the requisite public attention in Nigeria and many other countries. Therefore, this study aimed to determine the prevalence of anxiety disorders and depression among undergraduate students and the correlation between anxiety and depression among study participants.
Methods
We conducted a cross-sectional study of 877 undergraduates at Bowen University Hospital in Iwo Osun State, Nigeria, between October 2022 and May 2023.
Results
A total of 14.9%, 10.4%, and 1.9% of students had mild, moderate, and severe anxiety disorders, respectively. Similarly, 11.2%, 5.1%, and 0.5% of students had mild, moderate, and severe depression, respectively. The study showed a strong positive correlation between anxiety disorders and depression among undergraduate students.
Conclusion
This study revealed a high prevalence of anxiety and depression. There is a need for concerned authorities to have a blueprint for an efficient mental health support structure and ensure adequate training of personnel at university health centers.
Evaluating the Influence of Organic Waste Compost Amendments on Microbiome Richness and Diversity in Pre-Plantation and Post-Harvest Soils: Insights from 16S rRNA Metagenomic Profiling
Authors: Mahongnao Sophayo , Sharma Pooja , Ahamad Arif , Nanda Sarita 
Published: September 2023

Abstract
Understanding the dynamics of soil microbiomes is crucial for sustainable agriculture and developing effective soil management strategies. This study investigates the impact of leaf-based compost and other organic waste bio-compost amendments on the microbial richness and diversity in soils using 16S rRNA metagenomic profiling. Our results revealed significant variation of the microbiome richness and diversity on soil due to the bio-composts amendment. Interestingly, the bio-composts amendment resulted in a pronounced enrichment of beneficial microorganisms such as Achromobacter, Agromyces, Bacillus, Clostridium, Nitrospira, Planctomyces, Pseudomonas, Steroidobacter, Streptomyces, Alicyclobacillus, and Bdellovibrio, known for their roles in nutrient recycling, plant growth promotion, and disease suppression. The presence of pathogenic bacteria such as Flavobacterium, Leptolyngbya, Balneimonas, Geobacter, Nocardia, and Mycobacterium, were higher in the chemical fertilizer-amended soil sample than the bio-composts amended soils, which indicated the bioremediation of pathogens due to bio-compost amendment. Moreover, it was also observed that the microbiome population of the cultivars were affected by the bio-compost amendments. Generally, the organic cultivars produced using bio-compost amendments had higher beneficial microorganisms and lower pathogens than the conventional produce with chemical fertiliser amendment. Thus, leaf-based compost and other organic-waste compost could be used as bio-organic fertilizer for healthy sustainable productivity.
Locus of Decision-making and Treatment Preferences among Patients with Aplastic Anemia in China
Authors: Fa Cuiwen , Yang Fei , Jing Jun , Wu Jiahao , Chen Zhao 
Published: September 2023

Abstract
Aplastic Anemia (AA) is a non-malignant blood disorder characterized by anemia, bleeding, and increased susceptibility to infection, resulting in poor quality of life for patients. Despite extensive research, the disease remains challenging to cure, leaving patients with limited options for treatment. The incidence of AA in China is approximately 0.74 per 100,000 persons, posing a significant public health issue. Our study focused on investigating the decision-making process of AA patients in 16 provinces of China, utilizing both qualitative and quantitative research methods, including electronic questionnaire surveys and personal interviews. The study sample comprised 2155 participants from online patient organizations, and 186 valid responses were collected. The survey aims to identify the current treatment options utilized by AA patients, the source of medical decision-making, and other relevant information. The findings reveal that many treatments for AA are not covered by insurance, which results in significant financial burdens on patients and further diminishes their quality of life. Additionally, the social network surrounding AA patients significantly impacts their medical decisions, with many seeking input from healthcare providers, relatives, friends, and other AA patients, as well as media sources. In addition to biomedical treatment, patients with AA should explore alternative medical treatments, including traditional Chinese medicine, folk remedies, and other public medical practices.
Evaluation of a Virtual Reality Educational Program for Mindfulness and Emotional Management for Healthcare Professionals
Authors: Costa Jose Ferrer , Moran Nuria , Marti Carlos Garcia , Colmenares Leomar , Ciorba Florin Radu , Ciudad Maria Jose 
Published: September 2023

Abstract
Objective The main objective was to evaluate the impact of an 8-week virtual reality (VR) based educational program teaching mindfulness and emotional management techniques to healthcare professionals.
Methods Eighty-six healthcare professionals from two primary care centers and a palliative care team engaged in weekly 10-15 minute VR educational sessions. The sessions focused on teaching mindfulness techniques and emotional management tools. Burnout and work engagement levels were assessed using the Maslach Burnout Inventory (MBI) and Utrecht Work Engagement Scale (UWES) pre- and post-intervention.
Results Post-intervention data analysis revealed statistically significant reductions in emotional exhaustion and depersonalization, as well as enhancements in personal accomplishment, vigor, dedication, and absorption. Notably, professionals who exhibited elevated levels of work-related stress at baseline derived the most benefit from the educational content.
Conclusions The results emphasize the potential of employing VR as a medium to deliver educational content centered on mindfulness and emotional management, especially in the context of alleviating burnout among healthcare professionals. Such positive outcomes underscore the importance of investments in these programs, suggesting that they can contribute to superior patient outcomes and heightened service quality by reinforcing the emotional resilience of healthcare providers. To further comprehend the distinct advantages of VR in educational scenarios and ensure that all participants can avail its benefits, future research should contemplate more intricate experimental designs.
Perturbations in immune parameters Following Exposure to Manihot esculenta (Cassava)
Authors: Evbuomwan Lucky , Okojie Rachel Obhade , Anani Osikemekha Anthony 
Published: September 2023

Abstract

Cassava roots provide important sources of energy-rich food for millions of people. It is rich in two toxic cyanogenic glycosides. The study aimed to assess the impact of cyanide-containing food (Cassava) on hematological and histological parameters in experimental rats. Freshly prepared cassava products (fried garri and cassava paste) were obtained. Thirty-five (35) inbred male Swiss Rattus norvegicus were used for the study. There were two major animal groups, each divided into four other subgroups that contained five rats each. Subgroups were designated as A (only cassava form administration), B (cassava form and immunosuppressor), H (1mg/kg KCN), and I (only feed and water). All subgroups B received cyclophosphamide as a single dose on the 9th day. Animals were sacrificed on the 14th day. The data were analyzed using SPSS. Cyanide concentration was 133.16 ± 16.23 mg/kg in cassava paste and 59.40 ± 8.07 mg/kg in fresh fried garri. Results of white blood cell, red blood cell, monocyte, granulocyte, and neutrophil counts revealed lower levels in groups A, B, and H in rats exposed to freshly fried garri compared to group I. In rats exposed to fresh cassava paste, hematological parameters were similarly lower in groups A, B, and H compared to the normal control, where they were higher. When compared to the control group, there were various histological deformations observed in the liver, thymus, spleen, and kidney of the tested rat species like thickened centriole, adipose tissue, prominent dilated central artery, mild atrophic, and inflamed cells.
A case report of Graves Thyrotoxicosis associated with Pulmonary Hypertension
Authors: Wickramasinghe Malintha , Silva Shehan 
Published: September 2023

Abstract
Introduction
Pulmonary hypertension manifesting as a secondary cause has an extensive list of aetiology. Hyperthyroidism associated with pulmonary hypertension has been reported in a few case reports. Most of these have presented in an asymptomatic manner. A variety of mechanisms have been described in how thyrotoxicosis causes pulmonary hypertension.
Case Presentation
A 74-year-old woman with thyrotoxicosis due to Graves’ disease presented with bilateral pedal oedema and exertional shortness of breath suggestive of right heart failure. There was transthoracic echographic evidence of pulmonary hypertension. Commencement of oral carbimazole along with propranolol later once heart failure was controlled led to resolution complete resolution of pulmonary hypertension.
Conclusion
This case highlights the importance of considering thyrotoxicosis as a cause of pulmonary hypertension which can be completely resolved with the establishment of a euthyroid state. Although patients may present asymptomatic and are incidentally detected, the illness can manifest with features suggestive of right heart failure.
Network intervention analysis to assess the trajectory of chang and intervention effects associated with the use of self-control training for ego depletion aftereffects
Authors: Ying Junji , Zhang Xiaofang , Ren Lei , Wu Rihan , Xiao Wei , Liu Xufeng 
Published: September 2023

Abstract

Purpose: The purpose of this study was to use the advanced technique of Network Intervention Analysis (NIA) to investigate the trajectory of symptom change associated with the effects of self-control training on youth university students’ chronic ego depletion aftereffects.
Methods: The nine nodes of chronic ego depletion aftereffects and integrated self-control training were taken as nodes in the network and analyzed using NIA. Networks were computed at the baseline, at the end of treatment, at 1-, 3-, 6-, 9- and 12-month follow up.
Results: Self-control training interventions had a direct effect on low self-efficacy, low adherence, and work burnout, and had an indirect effect on fatigue, emotional regulation disorders, and other issues. Follow-up surveys showed that the intervention not only had immediate effects but also had long-term effects.
Conclusion: These findings indicate that self-control training has a direct intervention effect on low self-efficacy, low perseverance, and work fatigue of youth university students’ ego depletion aftereffects. This study is the first application of NIA in abnormal psychological state intervention research outside the field of mental disorder treatment. NIA is a promising method to evaluate the trajectories of intervention change and the direct and indirect effects of training interventions.
The application and influence of “Small Private Online Course” based on flipped classroom teaching model in the course of fundamental operations in surgery
Authors: Zhou Xiaoyi , Yu Guanyu , Li Xu , Zhang Wei , Nian Xinwen , Cui Jin , Wei Xianzhao , Sun Yu 
Published: September 2023

Abstract
Objective To investigate the influence of “Small Private Online Course” based on flipped classroom teaching model on the students in the course of fundamental operations in surgery.
Design A retrospective study.
ParticipantsThird-year undergraduates majored in clinical medicine in Navy medical university.
Main outcome measures The mastery of theoretical knowledge and operational skill of the students, the comparison of final test examination score between traditional teaching method and “SPOC + flipped classroom” model and the feedback completed by students.
Results Our study found that SPOC + flipped classroom could significantly increase the efficacy of the class and enhance the ability of the students compared with the traditional method.
Conclusions The new teaching model could have a positive influence for medical students on their basic knowledge and operational skill.
Automated Multi-Step Web Application Attack Analysis Using Reinforcement Learning and Vulnerability Assessment Tools
Authors: Hamidi Mohammad Sedigh , Doostari Mohammadali , Bijani Shahriar 
Published: September 2023

Abstract
Web applications remain persistently vulnerable to malicious attacks, necessitating a thorough exploration of adversarial strategies in multi-step web application attacks to proactively enhance preventive measures. Nonetheless, the complexity of such audits demands specialized expertise, and notably, the automation of this complicated process lacks practical methodologies. This paper presents an innovative approach that automates multi-step web application attacks by integrating reinforcement learning techniques with established tools like Metasploit, SQLmap, and Weevely. Within this framework, reinforcement learning agents exploit SQL injection and known vulnerabilities outlined in the OWASP Top Ten. A comparative analysis of two reinforcement learning models, Q-Learning and Deep Q-Network, reveals the superior reward accumulation prowess of the Q-Learning model during the training phase. Furthermore, the effectiveness of these trained agents is assessed using the vulnerable DVWA web application, demonstrating the Q-Learning-trained agent could gain persistent access to the web server and successfully extracting sensitive data.
Exploring the Temporal Dissolution of Gas Hydrates in the South Shetland Islands of Antarctica through Fluid Flow Simulations
Authors: Dogan Doga Dusunur , Turkdogan Selvican , Ocakoglu Neslihan , Tinivella Umberta , Giustiniani Michela , Altan Zehra , Gorum Tolga , Arik Sinan 
Published: September 2023

Abstract
Numerical models were used to study gas hydrates and free gas stability over time in gas hydrate-bearing sediments off the Antarctic Peninsula, South Shetland Islands, for the first time. Seismic data aided in creating a marine subsurface model, and ANSYS-Fluent was employed for multiphase simulations. Results revealed that in-situ faults played a crucial role in gas hydrate distribution, with CH4 being rapidly drained off, and CO2 and H2 emitted through the faults. Faults acted as fluid conduits, leading to high CO2 concentrations nearby. Dissolved methane accumulated in isolated clusters within marine sediments, with varying dissolution times depending on gas hydrate concentrations. This complex interplay of faults, fluid availability, bathymetry, and gas hydrate concentrations significantly influenced methane's fate and transport in marine environments.
Concordance of ALK fusion gene-rearrangement between immunohistochemistry and next-generation sequencing
Authors: Wakuda Kazushige , Morita Meiko , Sekikawa Motoki , Morikawa Noboru , Miura Keita , Doshita Kosei , Iida Yuko , Kodama Hiroaki , Mamesaya Nobuaki , Kobayashi Haruki , Ko Ryo , Ono Akira , Kenmotsu Hirotsugu , Naito Tateaki , Murakami Haruyasu , Muramatsu Koji , Kawata Takuya , Shimizu Tetsuo , Gon Yasuhiro , Takahashi Toshiaki 
Published: September 2023

Abstract
Background: Although various companion diagnostic tests of ALK fusion gene-rearrangement are approved, few reports have assessed the concordance of ALK fusion gene-rearrangement in two companion diagnostic tests: next-generation sequencing (NGS) testing and immunohistochemistry (IHC).
Methods: The samples evaluated for gene alterations using NGS testing between May 2019 and November 2021 were included in this study. The inclusion criteria were as follows: samples were diagnosed with non-small cell lung cancer; the results of the NGS analysis were informative; and samples had residual specimens for IHC. We performed IHC on the residual specimens and retrospectively collected sample characteristics from medical records.
Results: A total of 185 samples were analyzed using NGS. Twenty-six samples were excluded because of failure to analyze gene alterations using NGS, no residual samples, and inadequate IHC. We analyzed 159 samples. The major histological type was adenocarcinoma (115 samples). The number of surgical and transbronchial lung biopsy specimens was 59 and 56, respectively. ALK fusion gene-rearrangement was detected in four samples using NGS, and five were detected using IHC. The sensitivity and specificity of IHC referred to by NGS were 75.0% and 98.7%, respectively. The concordance rate between IHC and NGS was 98.1%. ALK rearrangement was detected in two patients using IHC but not using NGS. In addition, ALKrearrangement was detected in one patient using NGS but not using IHC.
Conclusions: Our results suggest that IHC and NGS might be complementary tests. In patients suspected of harboring ALK fusion gene-rearrangement, it should be analyzed using another diagnostic method.