bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of joint mobilization combined with acupuncture on pain, physical function, and depression in stroke patients with chronic neuropathic pain: A randomized controlled trial
Authors: Lee Ji-Eun , Akimoto Takayuki , Chang Jisuk , Lee Ho-Seong 
Published: August 2023

ObjectiveTo investigate the effectiveness of joint mobilization (JM) combined with acupuncture (AC) for the treatment of pain, physical function and depression in poststroke patients.MethodsA total of 69 poststroke patients were randomly assigned to the JM+AC group (n = 23), the JM group (n = 23), and the control group (n = 23). Patients in the JM+AC group and the JM group received JM for 30 minutes, twice a week for 12 weeks, and the JM+AC group received AC for 30 minutes separately once a week. The control group did not receive JM or AC. Pain (visual analog scale, shoulder pain and disability index, Western Ontario and McMaster universities osteoarthritis index), physical function (range of motion, 10-m walking speed test, functional gait assessment, manual function test, activities of daily living scale, instrumental activities of daily living scale), and depression (center for epidemiologic studies depression scale, Beck depression inventory) were assessed for each patient before and after the 12 weeks of intervention.ResultsPain and physical function were improved significantly in the JM+AC group compared with the JM and control groups. Physical function and depression were improved significantly in the JM+AC and JM groups compared with the control group.ConclusionThe treatment of JM combined with AC improved pain, depression, and physical function of poststroke patients with chronic neuropathic pain in this study. This valuable finding provides empirical evidence for the designing therapeutic interventions and identifying potential therapeutic targets.
Youth focused life skills training and counselling services program–An inter-sectoral initiative in India: Program development and preliminary analysis of factors affecting life skills
Authors: Melur Sukumar Gautham , Banandur Pradeep S. , Nagaraja Srividya Rudrapattana , Shenoy Anusha B. , Shahane Swati , Shankar Ravi G. , Banavaram Arvind Anniappan , Yekkar Gananatha Shetty , Rajneesh Shalini , Gopalkrishna Gururaj 
Published: August 2023

Objectives
This paper describes the methodology of developing and implementation of a youth focused life skills training and counselling services programme (LSTCP) and assessment of factors associated with life skills of participants pre-training.

Design
Development of all aspects of LSTCP (modules, methods and evaluation) was through a consultative process. Experiential learning based facilitation was decided as the approach for training participants. A quasi-experimental design with pre, post and follow-up assessment post-training was finalised. Data collection was done using specifically developed semi-structured self-administered questionnaire.

Results
Multivariable logistic regression with life skills as outcome and various exposure variables was performed. About 2/3rd of participants had high level of life skills (68%). Increased score of extraversion (AOR = 1.57,95% CI = 1.32–1.85), agreeableness (AOR = 1.42,95% CI = 1.16–1.73), conscientiousness (AOR = 1.9,95% CI = 1.55–2.33), physical (AOR = 1.03,95% CI = 1.01–1.04), environmental (AOR = 1.02,95% CI = 1.004–1.03) and social quality of life (AOR = 1.01,95% CI = 1.006–1.02) were associated with high life skills score. Higher score of neuroticism (AOR = 0.66,95% CI = 0.53–0.79) was associated with low life skills score.

Conclusion
The results presented provide an opportunity to understand the evolution of factors affecting life skills during the follow-up of this study. This study throws light on development of LSTCP for apparently healthy population in a setting like India and its states.
Postoperative opioid prescribing patients with diabetes: Opportunities for personalized pain management
Authors: Zammit Alban , Coquet Jean , Hah Jennifer , el Hajouji Oualid , Asch Steven M. , Carroll Ian , Curtin Catherine M. , Hernandez-Boussard Tina 
Published: August 2023

Background
Opioids are commonly prescribed for postoperative pain, but may lead to prolonged use and addiction. Diabetes impairs nerve function, complicates pain management, and makes opioid prescribing particularly challenging.

Methods
This retrospective observational study included a cohort of postoperative patients from a multisite academic health system to assess the relationship between diabetes, pain, and prolonged opioid use (POU), 2008–2019. POU was defined as a new opioid prescription 3–6 months after discharge. The odds that a patient had POU was assessed using multivariate logistic regression controlling for patient factors (e.g., demographic and clinical factors, as well as prior pain and opiate use).

Findings
A total of 43,654 patients were included, 12.4% with diabetes. Patients with diabetes had higher preoperative pain scores (2.1 vs 1.9, p<0.001) and lower opioid naïve rates (58.7% vs 68.6%, p<0.001). Following surgery, patients with diabetes had higher rates of POU (17.7% vs 12.7%, p<0.001) despite receiving similar opioid prescriptions at discharge. Patients with Type I diabetes were more likely to have POU compared to other patients (Odds Ratio [OR]: 2.22; 95% Confidence Interval [CI]:1.69–2.90 and OR:1.44, CI: 1.33–1.56, respectively).

Interpretation
In conclusion, surgical patients with diabetes are at increased risk for POU even after controlling for likely covariates, yet they receive similar postoperative opiate therapy. The results suggest a more tailored approach to diabetic postoperative pain management is warranted.
Impact of height difference between coronary ostium and location of intracoronary pressure sensor on fractional flow reserve measurements
Authors: Soh Moon-Seung , Kim Hangyul , Kang Min Gyu , Lee Hyo Jin , Lee Seung Do , Hwang Seok-Jae , Hwang Jin-Yong , Kim Kyehwan , Park Jeong-Rang , Kim Hye-Ree , Tahk Seung-Jea , Yoon Myeong-Ho , Lim Hong-Seok , Koh Jin-Sin 
Published: August 2023

Background
During fractional flow reserve (FFR) measurements, distal coronary pressure (Pd) can be influenced by hydrostatic pressure changes resulting from the height difference (HD) between the coronary ostium and the location of the distal pressure sensor.

Aims
We investigated the effect of aortocoronary HD on the FFR measurements in each coronary artery.

Methods
In this retrospective cohort study, we analyzed 257 patients who underwent FFR measurements and coronary computed tomography (CCTA) within a year. Using CCTA, we measured HD as the vertical distance between the coronary ostium and a matched point of the distal coronary pressure sensor identified on coronary angiography.

Results
The location of the Pd sensor was higher than the coronary ostium in the left anterior descending artery (LAD) (-4.64 ± 1.15 cm) and lower than the coronary ostium in the left circumflex artery (LCX) (2.54 ± 1.05 cm) and right coronary artery (RCA) (2.03 ± 1.28 cm). The corrected FFR values by HD were higher in the LAD (0.78 ± 0.09 to 0.82 ± 0.09, P<0.01) and lower in the LCX and RCA than the original FFR values (0.87 ± 0.07 to 0.85 ± 0.08, P<0.01; 0.87 ± 0.10 to 0.86 ± 0.10, P<0.01, respectively). Using an FFR cut-off value of 0.8, the concordance rates between the FFR and corrected FFR values were 77.8%, 95.2%, and 100% in the LAD, LCX, and RCA, respectively.

Conclusion
HD between the coronary ostium and the distal coronary pressure sensor may affect FFR measurements and FFR-guided treatment decisions for coronary artery disease.
Automated analysis of vessel morphometry in retinal images from a Danish high street optician setting
Authors: Freiberg Josefine , Welikala Roshan A. , Rovelt Jens , Owen Christopher G. , Rudnicka Alicja R. , Kolko Miriam , Barman Sarah A. ,   on behalf of the FOREVER consortium
Published: August 2023

Purpose
To evaluate the test performance of the QUARTZ (QUantitative Analysis of Retinal vessel Topology and siZe) software in detecting retinal features from retinal images captured by health care professionals in a Danish high street optician chain, compared with test performance from other large population studies (i.e., UK Biobank) where retinal images were captured by non-experts.

Method
The dataset FOREVERP (Finding Ophthalmic Risk and Evaluating the Value of Eye exams and their predictive Reliability, Pilot) contains retinal images obtained from a Danish high street optician chain. The QUARTZ algorithm utilizes both image processing and machine learning methods to determine retinal image quality, vessel segmentation, vessel width, vessel classification (arterioles or venules), and optic disc localization. Outcomes were evaluated by metrics including sensitivity, specificity, and accuracy and compared to human expert ground truths.

Results
QUARTZ’s performance was evaluated on a subset of 3,682 images from the FOREVERP database. 80.55% of the FOREVERP images were labelled as being of adequate quality compared to 71.53% of UK Biobank images, with a vessel segmentation sensitivity of 74.64% and specificity of 98.41% (FOREVERP) compared with a sensitivity of 69.12% and specificity of 98.88% (UK Biobank). The mean (± standard deviation) vessel width of the ground truth was 16.21 (4.73) pixels compared to that predicted by QUARTZ of 17.01 (4.49) pixels, resulting in a difference of -0.8 (1.96) pixels. The differences were stable across a range of vessels. The detection rate for optic disc localisation was similar for the two datasets.

Conclusion
QUARTZ showed high performance when evaluated on the FOREVERP dataset, and demonstrated robustness across datasets, providing validity to direct comparisons and pooling of retinal feature measures across data sources.
Endoscopist-Level and Procedure-Level Factors Associated With Increased Adenoma Detection With the Use of a Computer-Aided Detection Device
Authors: Shaukat Aasma , Lichtenstein David R. , Chung Daniel C. , Wang Yeli , Navajas Emma E. , Colucci Daniel R. , Baxi Shrujal , Coban Sahin , Brugge William R. 
Published: August 2023

INTRODUCTION:
To investigate the impact of procedure-related and endoscopist-related factors on the effectiveness of a computer-aided detection (CADe) device in adenomas per colonoscopy (APC) detection.

METHODS:
The SKOUT clinical trial was conducted at 5 US sites. We present prespecified analyses of procedure-related and endoscopist-related factors, and association with APC across treatment and control cohorts.

RESULTS:
There were numeric increases in APC between SKOUT vs standard colonoscopy in community-based endoscopists, withdrawal time of ≥8 minutes, for endoscopists with >20 years of experience, and endoscopists with baseline adenoma detection rate <45%.

DISCUSSION:
The application of CADe devices in clinical practice should be carefully evaluated. Larger studies should explore differences in endoscopist-related factors for CADe.
Hardy and BMO spaces on Weyl chambers
Authors: Plewa Paweł , Stempak Krzysztof 
Published: August 2023

Abstract
Let W be a finite reflection group associated with a root system R in

ℝ
d

{\mathbb{R}^{d}}

. Let

C
+

{C_{+}}

denote a positive Weyl chamber distinguished by
a choice of

R
+

{R_{+}}

, a set of positive roots. We define and investigate Hardy and BMO spaces on

C
+

{C_{+}}

in the framework of boundary conditions
given by a homomorphism

η
∈

Hom
⁡

(
W
,

ℤ
^

2

)

{\eta\in\operatorname{Hom}(W,\widehat{\mathbb{Z}}_{2})}

which attaches the

±

{\pm}

signs to the facets of

C
+

{C_{+}}

. Specialized to orthogonal root systems, atomic decompositions
in

H
η
1

{H^{1}_{\eta}}

and

h
η
1

{h^{1}_{\eta}}

are obtained and the duality problem is also treated.
Structure of generalized Jordan
*
*
-derivations on prime
*
*
-rings
Authors: Khan Abdul Nadim , Khan Mohammad Salahuddin 
Published: August 2023

Abstract
Let

ℛ

{\mathscr{R}}

be a prime ring, which is not commutative, with involution

*

{*}

and symmetric ring of quotients

𝒬
s

{\mathscr{Q}_{s}}

. The aim of the present paper is to describe the structures of a pair of generalized Jordan

*

{*}

-derivations of prime

*

{*}

-rings. Notably, we prove that if a noncommutative prime ring

ℛ

{\mathscr{R}}

with involution

*

{*}

admits a couple of generalized Jordan derivations

ℱ
1

{\mathcal{F}_{1}}

and

ℱ
2

{\mathcal{F}_{2}}

associated with Jordan

*

{*}

-derivations

𝒟
1

{\mathscr{D}_{1}}

and

𝒟
2

{\mathscr{D}_{2}}

such that

ℱ
1

⁢

(
x
)

⁢

x
*

-

x
⁢

ℱ
2

⁢

(
x
)

=
0

{\mathcal{F}_{1}(x)x^{*}-x\mathcal{F}_{2}(x)=0}

for all

x
∈
ℛ

{x\in\mathscr{R}}

, then the following holds:
(i) if

𝒟
1

⁢

(
x
)

=

𝒟
2

⁢

(
x
)

{\mathscr{D}_{1}(x)=\mathscr{D}_{2}(x)}

, then

ℱ
1

⁢

(
x
)

=

ℱ
2

⁢

(
x
)

=
0

{\mathcal{F}_{1}(x)=\mathcal{F}_{2}(x)=0}

for all

x
∈
ℛ

{x\in\mathscr{R}}

,
(ii) if

𝒟
1

⁢

(
x
)

≠

𝒟
2

⁢

(
x
)

{\mathscr{D}_{1}(x)\neq\mathscr{D}_{2}(x)}

, then there exists

q
∈

𝒬
s

{q\in\mathscr{Q}_{s}}

such that

ℱ
1

⁢

(
x
)

=

x
⁢
q

{\mathcal{F}_{1}(x)=xq}

, and

ℱ
2

⁢

(
x
)

=

q
⁢

x
*

{\mathcal{F}_{2}(x)=qx^{*}}

for all

x
∈
ℛ

{x\in\mathscr{R}}

.
Moreover, some related results are also discussed.
Adolescents and young adults communicating with gastroenterologists: variation in inflammatory bowel disease clinical communication
Authors: Karimi Neda , Lukin Annabelle , Moore Alison R. , Pipicella Joseph L. , Kanazaki Ria , Williams Astrid-Jane , Ng Watson , Kariyawasam Viraj , Mitrev Nikola , Pandya Keval , Connor Susan J. 
Published: August 2023

Abstract

Objectives
This study explored the variation in emerging adults’ communication with gastroenterologists around the management of inflammatory bowel disease (IBD).

Methods
Nineteen emerging adults with IBD aged 18–25 and seven gastroenterologists participated in the study. Outpatient specialist consultations of consenting participants were audio-recorded and transcribed. Transcribed consultations were analysed in terms of the linguistic structure of the consultations and the gastroenterologist-patient role relationship.

Results
Variations in the emerging adults’ communication with their gastroenterologists stem partly from variation in their ability, opportunity, or need to contribute to the different phases of the consultation and partly from variations in the gastroenterologists’ style of communication. Gastroenterologists differed in the construction of their role relationship with the patient, resulting in variations in employing empowering strategies including eliciting, exploring, and clarifying the patient’s concerns, sharing clinical reasoning, and validating the patient experience. Variations were also observed in the length of appointments and the gastroenterologists’ assessment and addressing of adherence issues. Techniques used by the gastroenterologist varied (1) from simply confirming adherence, to a comprehensive assessment of the patient’s understanding of their management plan and their feedback, and (2) from use of persuasion to values calibration.

Conclusions
Evidence-based consumer interventions and communication guidelines for clinicians are needed to address the identified variations in providing care to emerging adults living with chronic conditions.
RNAcode_Web – Convenient identification of evolutionary conserved protein coding regions
Authors: Anders John , Stadler Peter F. 
Published: August 2023

Abstract
The differentiation of regions with coding potential from non-coding regions remains a key task in computational biology. Methods such as RNAcode that exploit patterns of sequence conservation for this task have a substantial advantage in classification accuracy in particular for short coding sequences, compared to methods that rely on a single input sequence. However, they require sequence alignments as input. Frequently, suitable multiple sequence alignments are not readily available and are tedious, and sometimes difficult to construct. We therefore introduce here a new web service that provides access to the well-known coding sequence detector RNAcode with minimal user overhead. It requires as input only a single target nucleotide sequence. The service automates the collection, selection, and preparation of homologous sequences from the NCBI database, as well as the construction of the multiple sequence alignment that are needed as input for RNAcode. The service automatizes the entire pre- and postprocessing and thus makes the investigation of specific genomic regions for previously unannotated coding regions, such as small peptides or additional introns, a simple task that is easily accessible to non-expert users. RNAcode_Web is accessible online at rnacode.bioinf.uni-leipzig.de.
Systematic literature review of the epidemiology of glycogen storage disease type 1a
Authors: Zelei Tamás , Kovács Sándor , Finn Patrick , Nagy Dávid , Sikirica Vanja , Carlson Katherine B. , Vokó Zoltán 
Published: August 2023

Abstract
Glycogen storage disease (GSD) type 1a is an inherited autosomal recessive metabolic disease caused by a deficiency in glucose-6-phosphatase activity. The objectives of this research were to systematically review the published literature on the epidemiology of GSD 1a and to assess the performance of reported epidemiology measures in a simulation model. In this systematic literature review 2,539 record titles and abstracts were screened. Of these, only 11 studies contained relevant data on GSD 1a disease epidemiology. Reported disease frequency ranged from 0.085/100,000 to 10.3/100,000 newborns when considering all the GSD literature. When this was narrowed to GSD 1 and GSD 1a, the range was tightened to 0.25–3.02/100,000 and 0.085–4.9/100,000 newborns, respectively. Most of the identified studies counted the number of diagnoses in a defined period and related to the number of births in the same (Dx method) or different time period (DoB method). The simulation model results indicate that in most of the situations, the Dx method provides a closer estimate to the true disease incidence than the DoB method. Despite the scarcity of epidemiology data, the results of this systematic review strongly support that GSD 1a and its parent disease groups (GSD and GSD 1) are rare diseases.
Defending ‘Islamic Belief’ Against Discrimination: Religious Minority Group Discourse in Indonesia
Authors: Irawan Andi Muhammad , Syurganda Andi , Afdal Zul 
Published: August 2023

Abstract
This paper employs Critical Discourse Analysis to examine resistance discourses as created by the Ahmadiyya followers – a self-defined sect of Islam – to argue against negative discourses undermining them in Indonesia. In some legal proclamations and statements delivered by state officials and the representatives of majority Muslims in the country, the followers of the sect, especially those affiliated to the JAI (Jemaat Ahmadiyya Indonesia) are excluded from Islamic community. By using Van Dijk’s ideological square, this study aims at identifying resistance discourses created by the JAI followers as the defence strategies to oppose negative discourses presenting them as the non-believers of Islam. The resistance discourses are apparent in both written and spoken texts, such as books, articles, speeches, and public debates created by the sect. The finding reveals that the JAI followers create discourses of victim, defender of Islam, imperialism, illegitimacy, and discourse of public deception using various discourse strategies namely victimization, scare tactics, positive attribution, quotation, power delegitimising and negative portraits of misbehaving.
Researching of resistance to etravirine in some HIV-1 low-level viremia strains by in-silico methods
Authors: Oflaz Ofcan , Mergen Hatice , Demir Tülin 
Published: August 2023

Abstract

Objectives
Human immunodeficiency virus (HIV) is a significant infection that attacks immune system cells and integrates its genetic material into host cells. Left untreated, it leads to acquired immunodeficiency syndrome (AIDS). Antiretroviral therapy (ART) is used to control HIV infection. Etravirine (ETR) is an important non-nucleoside reverse transcriptase inhibitor (NNRTI) utilized in the treatment of HIV. Low-level viremia (LLW) is a serious clinical condition, and the underlying mechanisms remain incompletely understood. The aim of our study is to analyze and elucidate the resistance status of Lys104Gln, Lys102Gln, Lys101Arg-Lys104Arg, Ser191Phe, Ile94Leu-Lys104Arg, Lys104Glu-His235Leu, Ala98Ser and Val179Ile mutations using in-silico methods, which are identified as low-level viremic strains, because their resistance status to ETR is unknown.

Methods
Homology modeling was performed using the Swiss Model program. Molecular docking of ETR with the reverse transcriptase (RT) enzyme was conducted using the CB-Dock program developed by AutoDock Vina. Protein-ligand interaction analysis was carried out using the protein-ligand interaction profiler (PLIP).

Results
A98S and V179I mutations altered the physicochemical properties of the region, resulting in changes to the conformational structure of the NNRTI hydrophobic pocket compared to the wild-type and consequently decreased docking scores.

Conclusions
Based on the evaluation of literature data and in-silico analyses, it is believed that A98S and V179I mutations may alter the conformational structure of the hydrophobic pocket where ETR binds, potentially resulting in low-level resistance against ETR.
Nutritional Status of Patients with Chronic Critical Illness
Authors: Sergeev I. V. , Petrova M. V. , Shestopalov A. E. , Kanarsky M. M. , Lukyanets O. B. , Yarotskaya I. A. , Nekrasova Yu. Yu. 
Published: August 2023

Material and methods. We examined 23 patients with chronic critical illness who were in a minimally conscious state (MCS) with 10.9±2.5 scores on the FOUR (Full Outline of Unresponsiveness) Score Coma Scale. Indicators of carbohydrate, lipid, protein and energy exchange metabolism were evaluated using specimens sampled in the morning hours. Nutritional support was provided by isocaloric isonitrogenic mixtures.Results. Blood biochemistry showed decreases in total protein and albumin levels in 86.9% and 91.3% of patients, respectively. The tests also revealed decreased concentrations of several amino acids, including essential amino acids: histidine (38.3±13.07 µmol/l), methionine (12.68±3.81 µmol/l), threonine (61.6 [58.5;87.7] µmol/l), tryptophan (33.06±15.95 µmol/l), and non-essential amino acids: arginine (40.50 [22.2; 46.9] µmol/l), glutamic acid (124.5±39.29 µmol/l), tyrosine (37.97±10.12 µmol/l). Some correlations between the concentrations of individual amino acids and other indicators were revealed, such as histidine and CRP (r=–0.68, P=0.043), tryptophan and CRP (r=–0.86, P=0.002), histidine and leukocyte count (r=–0.76, P=0.015), methionine and lysine (r=0.88, P=0.008), methionine and patient's weight (r=–0.68, P=0.042). A relationship between threonine concentration and the level of consciousness on the FOUR scale (r=–0.73, P=0.037) was also found. All patients demonstrated significant alterations of carbohydrate and lipid metabolism.Conclusion. Alteration of adequate protein metabolism seems to be the most affected constituent in the nutritional status of patients with chronic critical illness. It is manifested by a decrease in the concentration of total protein and a number of essential and non-essential amino acids, which implies the importance of highprotein nutritional support and correction of the amino acid profile.