bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of lemon essential oil nanoemulsion and its effect on the microbial community of pork patties
Authors: Zou Bo , Shao Chuyao , Shao Lele , Zhao Yijie , Dai Ruitong , Liu Yi 
Published: April 2023

AbstractThe purpose of this study was to prepare an essential oil nanoemulsion and apply it to meat products to achieve antimicrobial effect. The nanoemulsion of lemon essential oil was produced by high power ultrasonication. The influences of ultrasonic power, ultrasonic time, and mass ratio of sodium caseinate to essential oil on the particle size were examined. The optimal conditions for preparing nanoemulsion were ultrasonic power 327 W, ultrasonic time 18 min, and sodium caseinate to essential oil mass ratio 4.23:1. Lower temperature was more conducive to the preservation of nanoemulsion. Compared to control and essential oil group, the nanoemulsion could decrease the total volatile basic nitrogen content and total bacterial colony in pork patties. When applied to pork patties, the nanoemulsion decreased the microbial diversity and inhibited the growth of a variety of microorganisms such as Bacillus, extending the storage time of pork patties. This study developed a novel and workable nanoemulsion for inhibiting bacteria of meat products.
Use of basal insulin in the management of adults with type 2 diabetes: An Asia‐Pacific evidence‐based clinical practice guideline
Authors: Ji Linong , Luo Yingying , Bee Yong Mong , Xia Jun , Nguyen Khue Thy , Zhao Weigang , Chen Liming , Chan Siew Pheng , Deerochanawong Chaicharn , Lim Soo , Yabe Daisuke , McGill Margaret , Suastika Ketut , Li Xiaoying , Kong Alice Pik Shan , Chen Wei , Zhao Zhan , Xu Chenchen , Deodat Marisa , Yao Xiaomei 
Published: April 2023

AbstractThe objective of this study was to provide recommendations regarding effectiveness, safety, optimal starting dose, optimal maintenance dose range, and target fasting plasma glucose of five basal insulins (glargine U‐300, degludec U‐100, glargine U‐100, detemir, and insulin protamine Hagedorn) in insulin‐naïve adult patients with type 2 diabetes in the Asia‐Pacific region. Based on evidence from a systematic review, we developed an Asia‐Pacific clinical practice guideline through comprehensive internal review and external review processes. We set up and used clinical thresholds of trivial, small, moderate, and large effects for different critical and important outcomes in the overall certainty of evidence assessment and balancing the magnitude of intervention effects when making recommendations, following GRADE methods (Grading of Recommendations, Assessment, Development, and Evaluation). The AGREE (Appraisal of Guidelines, Research and Evaluation) and RIGHT (Reporting Items for practice Guidelines in HealThcare) guideline reporting checklists were complied with. After the second‐round vote by the working group members, all the recommendations and qualifying statements reached over 75% agreement rates. Among 44 contacted external reviewers, we received 33 clinicians' and one patient's comments. The overall response rate was 77%. To solve the four research questions, we made two strong recommendations, six conditional recommendations, and two qualifying statements. Although the intended users of this guideline focused on clinicians in the Asia‐Pacific region, the eligible evidence was based on recent English publications. We believe that the recommendations and the clinical thresholds set up in the guideline can be references for clinicians who take care of patients with type 2 diabetes worldwide.
An unusual manifestation in a pediatric patient with MAFB mutation: Sacroiliitis in multicentric carpotarsal osteolysis syndrome
Authors: Kisla Ekinci Rabia Miray , Ozalp Ozge , Anlas Ozlem , Atmis Bahriye , Ata Aysun , Balci Sibel 
Published: April 2023

AbstractMulticentric carpotarsal osteolysis (MCTO) syndrome, is typically characterized by progressive bone resorption in especially carpal and tarsal bones, in addition to abnormal facial appearance and proteinuria. This disorder is caused by monoallelic pathogenic MAFB mutations, which result in excessive osteoclastogenesis via aberrant receptor activator of nuclear factor kappa‐B ligand activation. Most cases are sporadic with de‐novo mutations, and it is still unclear why carpal and tarsal bones are predominantly affected. The early phases of MCTO resemble juvenile idiopathic arthritis (JIA) with ankle and wrist swelling and pain, even with inflammatory changes in magnetic resonance imaging. Herein we report a pediatric patient, previously treated with antirheumatic drugs, and eventually diagnosed with MCTO. This case was a descriptive case with exophthalmos, significant proteinuria, and total loss of carpal and tarsal bones at the time of genetic diagnosis. Similar to the literature, our case had typical radiological findings despite methotrexate and anti‐tumor necrosis factor‐alpha treatment. However, while arthritis affecting joints other than wrists and ankles has not been reported so far in the literature, our case had bilateral sacroiliitis which completely resolved after adalimumab treatment. We cannot be sure if sacroiliitis was incidental or occurred as a component of the disease, nonetheless, we think that sharing our experience may lead to easy and early recognition of MCTO, with more knowledge on rare manifestations of MCTO, and thus we may be able to clarify the benefits of denosumab, which is the most promising agent in early phases of the disease.
Who is the convict; COVID‐19 or corticosteroid? Late onset avascular necrosis of hips after COVID‐19. A case report with literature review
Authors: Nejadhosseinian Mohammad , Haerian Hoda , Tabatabaie Nejad Marzie , Sadeghi Kourosh , Aghaghazvini Leila , Alikhani Majid , Loghman Maryam , Faezi Seyedeh Tahrerh 
Published: April 2023

AbstractAimAvascular necrosis (AVN) or osteonecrosis is characterized by death of bone tissue due to endothelial damage and vascular abnormality. Coronavirus can induce endothelial damage and abnormal blood clotting, so that COVID‐19 is known as a vascular disease. We aim to evaluate the relationship between AVN and COVID‐19.CaseHere we present a 39‐year old man with severe COVID‐19 and corticosteroid consumption who developed late onset AVN of both hips 20 month after COVID‐19.ConclusionAn awareness of the possible osteonecrosis for all physicians dealing with patients with musculoskeletal problems following COVID‐19 is necessary.
Safety of the pulmonary embolism rule‐out criteria rule: Findings from the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry
Authors: Truong Perrine , Mazzolai Lucia , Font Carme , Ciammaichella Maurizio , González‐Martínez José , Tufano Antonella , Gavín‐Sebastián Olga , Le Mao Raphael , Monreal Manuel , Hugli Olivier ,   the RIETE Investigators
Published: April 2023

AbstractBackgroundThe diagnostic strategy for pulmonary embolism (PE) includes a D‐dimer test when PE probability is low or intermediate, but false‐positive D‐dimer results are frequent and can result in an unnecessary computed tomography pulmonary angiogram. The PE rule‐out criteria (PERC) rule excludes PE without D‐dimer testing when pretest probability is <15%. The aim of this study was to assess the safety of the PERC rule strategy in patients included in the Registro Informatizado de la Enfermedad TromboEmbolica venosa (RIETE) registry.MethodsThis retrospective cohort study used data from the RIETE registry, an ongoing, international prospective registry of patients with objectively confirmed venous thromboembolism. The primary outcome was the failure rate of the PERC strategy, represented by the proportion of PERC‐negative (PERC‐N) patients with a PE included in the registry. Secondary outcomes were a comparison of the clinical characteristics, treatment strategy, and outcome of PERC‐N versus PERC‐positive (PERC‐P) patients at 3 months.ResultsFrom 2001 to 2021, a total of 49,793 patients with acute PE were enrolled in the RIETE registry. We included 48,903 in the final analysis after exclusion of 890 patients with an undetermined PERC status. Only 346 patients were PERC‐N with a failure rate of 0.7% (95% confidence interval 0.6%–0.8%). PERC‐N patients presented more frequently with chest pain but less often with dyspnea, syncope, or hypotension. They also had subsegmental or segmental PE more frequently, were more often treated with direct oral anticoagulants, and received mechanical or pharmacological thrombolysis less often. In addition, PERC‐N patients had a lower incidence of recurrent deep vein thrombosis, major bleeding, and death attributed to PE during the 3‐month follow‐up.ConclusionsA low failure rate of the PERC rule was observed in the RIETE registry, thus supporting its use to safely identify patients with an unlikely probability of PE.
Effect of different chelating agents on the shear bond strength of calcium silicate‐based cements to coronal dentin
Authors: Elsayed Mohamed Ahmed , Islam Md Sofiqul , Elbeltagy Karim , Nassar Mohannad 
Published: April 2023

AbstractWe evaluated the shear bond strength (SBS) of mineral trioxide aggregate (MTA) and Biodentine (BD) to coronal dentin after treatment with ethylenediaminetetraacetic acid (EDTA), phytic acid (IP6), or etidronic acid (HEDP). Sodium hypochlorite‐treated dentin surfaces were randomly divided into four groups according to conditioning protocol namely, 17% EDTA, 2.5% IP6, 9% HEDP, or distilled water (DS). Specimens were further divided according to the type of cement placed on conditioned dentin and SBS was tested. The results showed that DS/MTA and IP6/MTA groups had the highest values, and there was no significant difference between these two groups. IP6/BD group showed a lower SBS value compared to IP6/MTA; however, this did not reach the level of significance. The BS to dentin was influenced by the type of calcium silicate material and chelating agent. IP6 either improved or maintained the bonding while EDTA and HEDP showed a negative or no influence effect.
Binocular visual function improvement after pars plana vitrectomy for epiretinal membrane
Authors: Dormegny Lea , Foch Maxime , Messerlin Arnaud , Bourcier Tristan , Sauer Arnaud , Gaucher David 
Published: April 2023

AbstractPurposeTo report binocular visual function changes after pars plana vitrectomy for epiretinal membrane (ERM) and the related outcomes.MethodsTwenty‐three eyes of 23 patients operated on for ERM were included in a retrospective study. Clinical data, best‐corrected visual acuity (BCVA), contrast sensitivity and binocular visual function were assessed pre‐ and 1 and 3 months post‐operatively. Binocular visual function assessment included the evaluation of fusional amplitudes (i.e., vergences) by the synoptophore, far distance stereopsis using polarized glasses and near stereopsis using Randot and TNO tests. Central macular thickness (CMT) was measured on Spectral Domain – Optical Coherence Tomography.ResultsMean age of the patients was 67 years. Mean BCVA and contrast sensitivity significantly improved post‐operatively at one (p = 0.0006 and p = 0.0022, respectively) and 3 months (p < 0.0001 and p < 0.0001, respectively), while CMT significantly decreased after 1–3 months (p < 0.0001 and p < 0.0001, respectively). Fusional amplitudes improved after 3 months (p < 0.0001). Far distance and near stereopsis significantly improved after 3 months (p < 0.0001 and p = 0.0007 for Randot test, and p < 0.0001 for TNO test, respectively).ConclusionsPars plana vitrectomy for ERM surgery leads to an improvement of monocular and binocular visual functions (i.e., binocular fusion, near and far distance stereopsis), within 3 months post‐operatively.
Editorial: safety of topical steroids designed specifically for eosinophilic oesophagitis–new data bring new questions
Authors: Visaggi Pierfrancesco , Savarino Edoardo Vincenzo 
Published: April 2023

LINKED CONTENTThis article is linked to Hirano et al papers. To view these articles, visit https://doi.org/10.1111/apt.17430 and https://doi.org/10.1111/apt.17476
Meta‐analysis: Prevalence of significant or advanced fibrosis in adults with alpha‐1‐antitrypsin deficiency
Authors: Huang Daniel Q. , Chan Kai En , Tan Caitlyn , Zeng Rebecca Wenling , Koh Benjamin , Ong Elden Yen Hng , Ong Charlotte Chung Hui , Ong Christen En Ya , Tan Darren J. H. , Lim Wen Hui , Cho Elina , Tan Eunice X. X. , Teng Margaret L. P. , Ng Cheng Han , Nah Benjamin , Lim Mei Chin , Muthiah Mark , Clark Virginia C. , Loomba Rohit 
Published: April 2023

SummaryBackgroundThe prevalence of liver fibrosis detected by non‐invasive imaging in alpha‐1‐antitrypsin (AAT) deficiency has not been systematically assessed.AimsWe conducted a systematic review and meta‐analysis to determine the prevalence of significant fibrosis and advanced fibrosis in AAT deficiency based on non‐invasive imaging.MethodsMedline and Embase electronic databases were searched for studies from inception to 13 November 2022 that provided data for the prevalence of fibrosis in adults with AAT deficiency. A generalised linear mixed model with Clopper–Pearson intervals was used to pool single‐arm outcomes.ResultsOf the 214 records identified, 8 studies were included. Five studies assessed fibrosis using vibration‐controlled transient elastography. The prevalence of significant fibrosis (defined as ≥7.1 kPA) in Z homozygosity, Z heterozygosity and non‐carrier status was 22.10% (five studies, 95% CI: 17.07–28.12), 9.24% (three studies, 95% CI: 4.68–17.45) and 5.38% (one study, 95% CI: 3.27–8.73), respectively, p < 0.0001, and the prevalence of advanced fibrosis (defined as ≥9.5 kPa) was 8.13% (five studies, 95% CI: 4.60–13.96), 2.96% (three studies, 95% CI: 1.49–5.81) and 1.08% (one study, 95% CI: 0.35–3.28), respectively, p = 0.003. There were limited data regarding the use of magnetic resonance elastography or acoustic radiation force impulse to assess for fibrosis.ConclusionMore than one in five adult individuals with AAT deficiency and Z homozygosity harbour significant fibrosis, and nearly 1 in 10 harbours advanced fibrosis. The risk of fibrosis increases incrementally with the frequency of Pi*Z mutations.
Aged spaces in an era of austerity: Food bank use by older people
Authors: Slocombe Hannah 
Published: April 2023

AbstractIn the context of austerity and the COVID‐19 pandemic, this paper draws on 17 interviews conducted with frontline staff and volunteers to explore the use of food banks by older people in a highly deprived North‐West borough. Despite high levels of poverty amongst this age group, older people are infrequent users of food banks and it is their absence from these spaces, as opposed to their use of and experiences within food banks, that has often gained attention. By foregrounding this age group, this paper highlights different circumstances of use, generational dynamics involving heightened feelings of shame, and how food banks function as social spaces for older people. In doing so, this paper adds to literature in gerontology around spaces of ageing, as well as research on food banks, by highlighting how experiences in these spaces are differentiated by age. This paper advances discussions around the impact of austerity on the everyday lives of older people. Due to the timing of this research, it also gives insight into how older people and informal social spaces have been affected by the COVID‐19 pandemic.
Hooked on a memory: How rumination about past positive events might contribute to grandiose ideas?
Authors: Bortolon Catherine , Baeyens Céline , Raffard Stéphane 
Published: April 2023

AbstractObjectivesDwelling about positive experiences has been found to be positively related to mania and grandiose ideas. Nevertheless, besides some important limitations, past research has also neglected the nature (or characteristics) of memories individuals dwell on, and that might be specifically associated with grandiose ideas. Thus, the present study aimed to replicate previous studies while considering the role of specificity and the importance of memory used to increase grandiose feelings.MethodIn total, 219 participants were included and, after completing the memory induction, were randomized to either the rumination condition or the distraction condition. They also completed different questionnaires assessing positive rumination and grandiose ideas.ResultsOverall, rumination, compared to the distraction condition, led to the maintenance of grandiose ideas and positive affect from T2 to T3. Regression analysis showed that the specificity of memory was associated with grandiose ideas at T2, which predicted grandiose ideas at T3.ConclusionsOur results confirm rumination's causal role in forming grandiose ideas. We also found that autobiographical memory and, more specifically, the capacity to recall past positive experiences coupled with repeatedly thinking about them might constitute a fundamental pathway leading to the persistence of such beliefs. The use of a non‐clinical sample limits the results and needs replication in clinical samples.
Age‐related immune cell dynamics influence outcomes after allogeneic haematopoietic cell transplantation
Authors: Jandin Alizée , Pochon Cécile , Campidelli Arnaud , D'Aveni Maud , Kicki Céline , Notarantonio Anne‐Béatrice , Roth Guepin Gabrielle , Mbuyi Tshinguta Anita , Feugier Pierre , Chastagner Pascal , Schweitzer Cyril , de Carvalho Bittencourt Marcelo , Rubio Marie Thérèse , Pagliuca Simona 
Published: April 2023

SummaryAn efficient immunological reconstitution construes the pillar for the success of allogeneic haematopoietic cell transplantation (HCT) in haematological disorders. Factors influencing post‐transplant immune recovery have been largely investigated across multiple cohorts issuing heterogeneous results. Differences in outcomes in adult and paediatric populations suggest an age‐related contribution to post‐transplant immune reconstitution; however, it is unclear how recipient and donor age may affect the dynamics of single immune cells. Here, we retrospectively collected and analysed immunological data of 174 patients (58 children and 116 adults) consecutively transplanted for haematological disorders in our centre. We show that trajectories of specific immune cells were strictly dependent on recipient age and pretransplant virus exposure, with the strongest effect seen on T CD4+ and B‐cell counterparts, while donor age and transplant platforms had a minimal impact. This mirrored different kinetics of immune reconstitution in adult and paediatric patients, with major divergences in immune cell composition in late post‐transplant phases, featuring better survival, relapse‐free survival and cumulative incidence of pathogen‐specific infections in younger patients. Altogether, these findings underpin the importance of recipient age on post‐transplant immune cell recovery and define the basic dynamics of the immune reconstitution in paediatric and adult populations as a benchmark for future studies.
Cognitive behavioural therapy for psychogenic nonepileptic seizures (PNES) in an adult with a learning disability: A case study
Authors: Radez Jerica , Crossland Tom , Johns Louise 
Published: April 2023

AbstractBackgroundPsychogenic nonepileptic seizures (PNES) are attacks that often look like epileptic seizures (ES). Unlike ES, PNES are not triggered by underlying neurological factors. PNES are relatively rare in the general population; however, their prevalence in people with learning disabilities is much higher—up to 10%. Individuals with PNES and learning disabilities often have psychiatric comorbidities, such as anxiety disorders, depression and posttraumatic stress disorder. There are currently no treatment guidelines for PNES in people with or without learning disabilities. However, talking therapies, such as cognitive‐behavioural therapy (CBT), are recommended. This study explores the effectiveness of CBT for the treatment of PNES in a woman (Susan) with PNES and learning disabilities.MethodsWe used a single‐case experimental design (SCED) to investigate the effectiveness of CBT intervention. Specifically, the withdrawal (also known as ABA) design was applied. The patient's average PNES frequency, as well as idiosyncratic mood measure and standardised outcome measures for people with learning disabilities (Glasgow Anxiety Scale for People with an Intellectual Disability and Mini‐Maslow Assessment of Needs Scale‐Learning Disabilities), were used to assess the effectiveness of treatment.FindingsResults show that Susan's monthly PNES frequency reduced from phase A1 (assessment phase) to phase B (treatment phase), and this persisted to the follow‐up phase (phase A2). However, the reduction was not statistically significant. The intervention was associated with improvements in Susan's mood, anxiety and quality of life. Reduction of Susan's anxiety was clinically significant.ConclusionsThis SCED study demonstrates that CBT might be associated with reduction of PNES frequency and improvements in general functioning in people with PNES and learning disabilities; however, further research, especially around confounding variables is needed.
Tiratricol, a thyroid hormone metabolite, has potent inhibitory activity against human dihydroorotate dehydrogenase
Authors: Cao Shuying , Ma Hui , Xu Zhaomin , Fang Wenqing , Huang Jin , Huang Ying 
Published: April 2023

AbstractHuman dihydroorotate dehydrogenase (hDHODH) is a promising drug target for many diseases including autoimmune diseases, cancer, and viral infection. To develop more novel and potent hDHODH inhibitors, we screened our in‐house library of old drugs. We found that tiratricol (3,3′,5‐triiodothyroacetic acid), a thyroid hormone metabolite, has potent hDHODH inhibitory activity (IC50: 0.754 ± 0.126 μM), and its precursor tetrac (3,3′,5,5′‐tetraiodothyroacetic acid) also shows a certain inhibitory activity against hDHODH (IC50: 11.960 ± 1.453 μM). Enzyme kinetic analysis shows that tiratricol and tetrac are noncompetitive inhibitors versus CoQ0, which is different from the positive control A771726. ThermoFMN assay, molecular docking and site‐directed mutagenesis all indicate that tiratricol and tetrac interact with more key residues of hDHODH than A771726, especially some hydrophobic residues in Subsite 1. In conclusion, our experiment results indicate a potential new use for the old drug, tiratricol, and provide a novel chemical scaffold for the design of hDHODH inhibitors.
Prediction of lymph node metastasis of well‐differentiated rectal neuroendocrine tumours using multiple diagnostic modalities
Authors: Emoto Shigenobu , Kawai Kazushige , Nozawa Hiroaki , Sasaki Kazuhito , Murono Koji , Yokoyama Yuichiro , Abe Shinya , Nagai Yuzo , Sonoda Hirofumi , Ishihara Soichiro 
Published: April 2023

AbstractAimThe preoperative prediction of lymph node metastasis of well‐differentiated rectal neuroendocrine tumours is highly desirable and useful in defining surgical indication more accurately. We aimed to evaluate lymph node metastasis in rectal neuroendocrine neoplasms using multiple imaging modalities.MethodsThe clinical records and radiological images of 70 patients with well‐differentiated rectal neuroendocrine tumours who received treatment at the University of Tokyo Hospital between 2010 and 2022 were retrospectively analysed. The relationship between evaluation by multiple imaging modalities and pathological lymph node metastasis was analysed.ResultsThe receiver operating characteristic curves showed that a maximum lymph node diameter ≥4 mm on computed tomography and ≥8 mm on magnetic resonance imaging were the optimal predictive factors for lymph node metastasis. Accumulation in the lymph nodes on somatostatin receptor scintigraphy (P = 0.058) and Delle's findings on colonoscopy (P = 0.014) were also significant predictors of pathological lymph node positivity, and combination of multiple modalities was useful. Pathologically, lymphatic (P = 0.0030)/venous (P = 0.0007) invasion were risk factors for lymph node metastasis.ConclusionsIn addition to pathological risk factors, a combination of multiple radiological imaging modalities is useful for predicting lymph node metastasis in well‐differentiated rectal neuroendocrine tumours.