bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of selective serotonin reuptake inhibitors and tricyclic antidepressants in addressing reduction of Meniere's disease burden: A scoping review
Authors: Missner Alexander A. , Sheykhsoltan Mana , Hakimi Amir , Hoa Michael 
Published: August 2023

AbstractObjectiveTo assess the effect of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) in reducing vertigo, tinnitus, and hearing loss among patients with Meniere's disease (MD).Data SourcesThe following databases were utilized in this scoping review: Ovid Medline, PubMed‐NCBI, CINAHL, Cochrane Library, Web of Science, and Clinicaltrials.gov.MethodStudies were identified through the following search phrases: “serotonin specific reuptake inhibitors” OR “tricyclic antidepressants” AND “Meniere's disease.” References from included manuscripts were examined for possible inclusion of additional studies.ResultsThe literature search yielded 23 results, which were screened by three independent reviewers. Seventeen studies and three duplicates were excluded. An examination of references from the included studies yielded two additional publications. A total of four published studies assessing SSRIs and TCAs among 147 patients with MD were ultimately included. Four studies described significant reductions in vertigo attack frequency among patients treated with either SSRIs or TCAs compared to their pretreatment baseline. Three studies assessed the drugs' effects on hearing, of which none found a significant difference among patients treated with SSRIs or TCAs. One study found a significant decrease in patient‐reported tinnitus following treatment with TCAs or SSRIs compared to their pretreatment baseline.ConclusionsData exploring SSRIs and TCAs among patients with MD suggests that these medications may reduce the frequency of tinnitus and vertigo, although there was significant heterogeneity in outcome reporting. There remains a need for larger‐scale prospective studies that emphasize objective data to evaluate their effectiveness in reducing common MD symptoms.
Normal Cyber-Crises
Authors: Backman Sarah 
Published: August 2023

AbstractDespite an increasing scholarly interest in cyber-security issues, the phenomenon of large-scale cyber-crises affecting critical infrastructure is largely unexplored. While some characteristics of its consequence dynamics have been identified—prominently its transboundary features—the underlying conditions that allow such dynamics to unfold have not yet been thoroughly explored. This chapter aims to contribute to bridging this gap by applying the classical theoretical perspectives of Normal Accidents (NA) and High Reliability organisations (HRO) on the sociotechnical systems of modern critical infrastructure. It argues that NA characteristics (the combination of interactive complexity and tight coupling) can be found in multiple layers of critical infrastructure operations (technical, cognitive, organisational and macro). Implications are discussed in terms of its connection to transboundary crisis dynamics.
Kapitel 2: Profiling
Authors: Wiedemann Klaus 
Published: August 2023

ZusammenfassungVor Inkrafttreten der Datenschutz-Grundverordnung bestand im europäischen Rechtsraum keine rechtlich verbindliche Definition des Begriffs Profiling. Er wurde weder in der Datenschutz-Richtlinie 94/46/EG noch in den verschiedenen Fassungen des Bundesdatenschutzgesetzes verwendet. Auch ansonsten besteht keine fest etablierte Definition. In der vorliegenden Arbeit wird als Ausgangspunkt der Untersuchungen auf die Legaldefinition in Art. 4 Nr. 4 DSGVO zurückgegriffen, um den Begriff im Kontext der Verordnung zu konkretisieren.
Health-related quality of life of children with first onset steroid-sensitive nephrotic syndrome
Authors: Veltkamp Floor , Teela Lorynn , Luijten Michiel A. J. , van Oers Hedy A. , Mak-Nienhuis Elske M. , Haverman Lotte , Bouts Antonia H. M. ,   on behalf of the LEARNS consortium, Adeel Abdul , Bael Anna , Bouts Antonia H. M. , Buter Nynke H. , van der Deure Hans , Dorresteijn Eiske , Florquin Sandrine , Gracchi Valentina , Horuz Flore , Kloosterman-Eijgenraam Francis , Levtchenko Elena , Mak-Nienhuis Elske M. , Mathôt Ron A. A. , Oversteege Floor , de Pont Saskia , van Rooij-Kouwenhoven Roos W. G. , Schreuder Michiel F. , Schriemer Rixt , Vos Paul , Walle Johan Vande , van Wijk Joanna A. E. 
Published: August 2023

AbstractThis study assessed HRQoL and emotional and behavioral difficulties (EBD) and associated variables in children with first onset SSNS. While relapsing steroid-sensitive nephrotic syndrome (SSNS) in children is associated with lower health-related quality of life (HRQoL), little is known about first onset. Four weeks after onset, children (2–16 years) and/or their parents who participated in a randomized placebo-controlled trial, completed the Pediatric Quality of Life Inventory 4.0 (PedsQL) and Strengths and Difficulties Questionnaire (SDQ) to measure HRQoL and EBD, respectively. Total and subscale scores and the proportion of children with impaired HRQoL (> 1 SD below the mean of the reference group) or SDQ clinical scores (< 10th and > 90th percentile) were compared to the Dutch general population (reference group). Regression analyses were used to identify associated variables. Compared to the reference group, children 8–18 years reported significantly lower total HRQoL, and physical and emotional functioning. A large proportion (> 45%) of these children had impaired HRQoL. There were no differences in HRQoL between children 2–7 years and the reference group, except for higher scores on social functioning (5–7 years). Similar proportions of SSNS and reference children scored within the clinical range of SDQ subscales. Age, sex, and steroid side-effects were negatively associated with HRQol and/or EBD. Conclusion: This study showed that HRQoL and EBD are affected in children of different ages with first onset SSNS. This calls for more awareness from healthcare providers and routinely monitoring of HRQoL and EBD in daily clinical care to prevent worsening of symptoms. Clinical trial registry: Netherlands Trial Register (https://trialsearch.who.int/; NTR7013), date of registration: 02 June 2018.

What is Known:• Health-related quality of life (HRQoL) is lower and emotional and behavioral difficulties (EBD) is more affected in children with frequently-relapsing and steroid-dependent nephrotic syndrome.

What is New:• HRQoL and EBD are affected in children with first onset steroid-sensitive nephrotic syndrome compared to a reference group of the Dutch general population.• To what extent HRQoL and EBD are affected depends on the age of the patient.
Epidemiology of proximal femur fractures in the young population of Qatar
Authors: Hantouly Ashraf T. , AlBarazanji Asim , Al-Juboori Mohammed , Alebbini Mohanad , Toubasi Ahmad A. , Mohammed Asma , Alzobi Osama , Ahmed Ghalib 
Published: August 2023

Abstract
Purpose
To review the epidemiological characteristics of proximal femur fractures in the young population (< 60 years) of Qatar between 2017 and 2019.

Methods
All patient treated for proximal femur fractures at Hamad General Hospital (HGH), a level one trauma center, were retrospectively reviewed between Jan 2017 and Dec 2019. All adults (18–60 years) with proximal femur fracture (femur head, femur neck, intertrochanteric and subtrochanteric fractures) were included with no restriction to the AO/OTA classification or fractures subtypes. Excluded cases were pathological fractures, cases with insufficient documentation or no radiographs.

Results
A total of 203 patients with a mean age of 40.07 ± 11.76 years were included, of who 89.9% were males. The incidence of proximal femur fracture was 3.12/100,000/year. Fall from height (48.1%) followed by road traffic accidents (26.9%) were common cause of injury. The most common fracture type was intertrochanteric fracture (36.1%) followed by femur neck fractures (33.7%).

Conclusion
This study provides the initial insights into the proximal femur fractures in the young population of Qatar. This is the first study to investigate of the epidemiology of such fractures in this particular patient group. Contrary to the existing literature on older age groups, the majority of the injuries were observed in males. Falls from height followed by road traffic accidents were the primary mechanisms leading to these fractures. Improved understanding of the profile of these injuries can aid in their prevention by implementing more effective safety measures.
First-line nivolumab plus ipilimumab in metastatic non-small cell lung cancer: 5-year outcomes in Japanese patients from CheckMate 227 Part 1
Authors: Nishio Makoto , Ohe Yuichiro , Ikeda Satoshi , Yokoyama Toshihide , Hayashi Hidetoshi , Fukuhara Tatsuro , Sato Yuki , Tanaka Hiroshi , Hotta Katsuyuki , Sugawara Shunichi , Daga Haruko , Okamoto Isamu , Kasahara Kazuo , Naito Tateaki , Li Li , Gupta Ravi G. , Bushong Judith , Mizutani Hideaki 
Published: August 2023

Abstract
Background
In CheckMate 227 Part 1 (NCT02477826), first-line nivolumab plus ipilimumab demonstrated long-term durable overall survival (OS) benefit versus chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC), regardless of tumor programmed death ligand 1 (PD-L1) expression. We report results in Japanese patients with ≥ 5-year follow-up.

Methods
Adults with stage IV/recurrent NSCLC without EGFR/ALK aberrations were randomized 1:1:1 to nivolumab plus ipilimumab, nivolumab alone, or chemotherapy (patients with tumor PD-L1 ≥ 1%), or nivolumab plus ipilimumab, nivolumab plus chemotherapy, or chemotherapy (patients with tumor PD-L1 < 1%). Five-year efficacy and safety were assessed in Japanese patients.

Results
At 62.1 months’ minimum follow-up, 143 Japanese patients with PD-L1 ≥ 1% or < 1% were randomized to nivolumab plus ipilimumab (n = 66) or chemotherapy (n = 77). Five-year OS rates were 46% with nivolumab plus ipilimumab versus 34% with chemotherapy (PD-L1 ≥ 1%) and 36% versus 19% (PD-L1 < 1%). Median duration of response was 59.1 versus 7.1 months (PD-L1 ≥ 1%) and 17.3 versus 3.0 months (PD-L1 < 1%). Among 5-year survivors treated with nivolumab plus ipilimumab (PD-L1 ≥ 1% and < 1%; n = 27), 59% (95% CI, 39%–75%) were off treatment for ≥ 3 years without receiving subsequent therapy. No new safety signals were observed.

Conclusions
At 5-year follow-up, nivolumab plus ipilimumab continued to show long-term durable clinical benefit versus chemotherapy, regardless of tumor PD-L1 expression. Consistent with findings for the global population, these data support the use of nivolumab plus ipilimumab as first-line treatment in Japanese patients with metastatic NSCLC.
A systematic review of the impact of postoperative aerobic exercise training in patients undergoing surgery for intra-abdominal cancers
Authors: Paul M. , Smart T. F. , Doleman B. , Toft S. , Williams J. P. , Lund J. N. , Phillips B. E. 
Published: August 2023

Abstract
Introduction
Enhanced recovery after surgery (ERAS) programmes which advocate early mobility after surgery have improved immediate clinical outcomes for patients undergoing abdominal cancer resections with curative intent. However, the impact of continued physical activity on patient-related outcomes and functional recovery is not well defined. The aim of this review was to assess the impact of postoperative aerobic exercise training, either alone or in conjunction with another exercise modality, on patients who have had surgery for intra-abdominal cancer.

Methods
A literature search was performed of electronic journal databases. Eligible papers needed to report an outcome of aerobic capacity in patients older than 18 years of age, who underwent cancer surgery with curative intent and participated in an exercise programme (not solely ERAS) that included an aerobic exercise component starting at any point in the postoperative pathway up to 12 weeks.

Results
Eleven studies were deemed eligible for inclusion consisting of two inpatient, one mixed inpatient/outpatient and eight outpatient studies. Meta-analysis of four outpatient studies, each reporting change in 6-min walk test (6MWT), showed a significant improvement in 6MWT with exercise (MD 74.92 m, 95% CI 48.52–101.31 m). The impact on health-related quality of life was variable across studies.

Conclusion
Postoperative exercise confers benefits in improving aerobic function post surgery and can be safely delivered in various formats (home-based or group/supervised).
Losses of lifetime employment duration and productivity for patients with different subtypes and stages of lung cancer
Authors: Yang Szu-Chun , Lai Wu-Wei , Wu Tzu-I. , Hwang Jing-Shiang , Wang Jung-Der , Wang Fuhmei 
Published: August 2023

Abstract
Background
How different subtypes and stages of lung cancer affect morbidity- and mortality-associated productivity have not been investigated. This study quantified the losses of lifetime employment duration and productivity among patients with various subtypes and stages of lung cancer.

Methods
We identified nationwide lung cancer patients diagnosed at the ages of 50–64 between 2011 and 2019. Monthly survival probabilities were weighted by monthly employed-to-population ratios and working salaries to estimate lifetime employment duration and productivity. We compared lifetime employment duration and productivity of patients with those of the age-, sex-, calendar year-matched general population for losses of lifetime employment duration and productivity, which were multiplied by pathology and stage shifts based on the first-round screening of Taiwan Lung Cancer Screening in Never Smoker Trial (TALENT) to calculate the savings of lifetime employment duration and productivity.

Results
Lung cancer patients had shorter survival and employment duration than the referents. Patients with lung cancers other than adenocarcinoma experienced greater losses of lifetime employment duration and productivity as compared to adenocarcinoma patients. Applying the estimations of never-smoking patients to 100 lung cancer patients with pathology and stage shifts based on the TALENT, the savings of lifetime employment duration and productivity were 132.2 (95% prediction interval: 116.2–147.4) years and 3353 (95% prediction interval: 2914–3802) thousand US dollars, respectively.

Conclusions
Early diagnosis of lung cancer would save the losses of employment duration and lifetime productivity. Future evaluation of the cost-effectiveness of lung cancer screening could consider incorporating these societal impacts.
HIV Testing Disruptions and Service Adaptations During the COVID-19 Pandemic: A Systematic Literature Review
Authors: Mude William , Mwenyango Hadijah , Preston Robyn , O’Mullan Catherine , Vaughan Geraldine , Jones Gary 
Published: August 2023

AbstractAccess to treatment and care in safe clinical settings improves people’s lives with HIV. The COVID-19 pandemic disrupted vital HIV programs and services, increasing the risk of adverse health outcomes for people with HIV and HIV transmission rates in the community. This systematic literature review provides a meta-analysis of HIV testing disruptions and a synthesis of HIV/AIDS services adapted during COVID-19. We searched scholarly databases from 01 January 2020 to 30 June 2022 using key terms on HIV testing rates and services during the COVID-19 pandemic. The process of how the included articles were identified, selected, appraised, and synthesised was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We included 17 articles that reported changes in HIV testing during the COVID-19 pandemic and 22 that reported adaptations in HIV/AIDS services. We found that HIV testing decreased by 37% during the search period because of the COVID-19 pandemic. Service providers adopted novel strategies to support remote service delivery by expanding community antiretroviral therapy dispensing, setting up primary care outreach points, and instituting multi-month dispensing services to sustain client care. Therefore, service providers and policymakers should explore alternative strategies to increase HIV testing rates impacted by COVID-19 and leverage funding to continue providing the identified adapted services.
A systematic review of federated learning from clients’ perspective: challenges and solutions
Authors: Shanmugarasa Yashothara , Paik Hye-young , Kanhere Salil S. , Zhu Liming 
Published: August 2023

AbstractFederated learning (FL) is a machine learning approach that decentralizes data and its processing by allowing clients to train intermediate models on their devices with locally stored data. It aims to preserve privacy as only model updates are shared with a central server rather than raw data. In recent years, many reviews have evaluated FL from the system (general challenges) or server’s perspectives, ignoring the importance of clients’ perspectives. Although FL helps users have control over their data, there are many challenges arising from decentralization, specifically from the perspectives of clients who are the main contributors to FL. Therefore, in response to the gap in the literature, this study intends to explore client-side challenges and available solutions by conducting a systematic literature review on 238 primary studies. Further, we analyze if a solution identified for one type of challenge is also applicable to other challenges and if there are impacts to consider. The conclusion of this survey reveals that servers and platforms have to work with clients to address client-side challenges.
Noise traders in an agent-based artificial stock market
Authors: Dai Xiaoting , Zhang Jie , Chang Victor 
Published: August 2023

AbstractThis paper investigates whether noise traders can survive in the long run and how they influence financial markets by proposing an agent-based artificial stock market, as one simulation model of computational economics. This market contains noise traders, informed and uninformed traders. Informed and uninformed traders can learn from information by using Genetic Programming, while noise traders cannot. The system is first calibrated to real financial markets by replicating several stylized facts. We find that noise traders cannot survive or they just transform to other kind of traders in the long run, and they increase market volatility, price distortion, noise trader risk, and trading volume in the market. However, regulation intervention, e.g., price limits, transaction tax and longer settlement cycle, can affect noise trader’s surviving period and their influence on markets.
When the push and pull factors in digital educational resources backfire: the role of digital leader in digital educational resources usage
Authors: Asante Kwadwo , Novak Petr 
Published: August 2023

AbstractThe study investigated the impact of digital leadership on teachers’ usage of digital educational resources (DERs). The study collected data from teachers and headteachers in four pre-tertiary schools in Ghana. Also, trust was included as the interacting variable to examine its mediating role in digital leadership and digital educational resource usage to better disentangle the relationship between digital leadership and digital educational resource. The study used symmetrical (Partial Least Square-Structural Equation Modelling (PLS-SEM) and asymmetrical approaches (fuzzy-set Qualitative Comparative Analysis (fsQCA) for the analysis of the relationships. The results underpin digital leadership’s importance in digital educational resource implementation outcomes in developing countries’ pre-tertiary schools. The fuzzy-set qualitative comparative analysis findings confirm that exclusively using symmetrical approaches for digital educational resource studies may not be sufficient to understand the expected relationships within a proposed model. Under the partial least squares path modelling (PLS-SEM) analysis, trust did not mediate the relationship between digital leadership and teachers’ usage of digital educational resources. Sharply from the PLS-SEM findings, the fsQCA revealed that the presence of digital leadership and trust are necessary conditions to predict teachers’ usage of digital educational resources. These results and their implications for theory and practice are discussed.
Determinants of eco-innovation in the agricultural machinery sector: the case of small and medium enterprises in the Piedmont region (Italy)
Authors: Bagagiolo Giorgia , Vigoroso Lucia , Caffaro Federica , Cavallo Eugenio 
Published: August 2023

AbstractThe agricultural machinery industry can significantly contribute to a more sustainable farming system through the development of eco-innovative products and production processes. This is particularly true for small and medium enterprises (SMEs), which represent a significant share of this market. This study investigated the determinants of attitudes towards eco-innovating products and processes in a sample of small and medium agricultural machinery manufacturers (N = 47) from the Piedmont region (North–West Italy), analysing the role of enterprise’s characteristics, perceived drivers and barriers, and environmental concern. Overall, product eco-innovation was considered important/very important for their firms by 88.3% of the respondents, whereas process eco-innovation by 67.7%. The regression analyses showed that the availability of a formal and hierarchical structure dedicated to Research and Development and of financial support were significantly associated (β = 0.301, p = .032 and β = 0.406, p = .011, respectively) to positive attitudes towards eco-innovating production processes, whereas the lack of know-how was the main obstacle to both product and process eco-innovativeness (β = − 0.564, p = .000 and β= − 0.397, p = .008, respectively). Environmental concern did not show any significant association with firms’ perceived importance to eco-innovate either products (β = 0.097, p = .475) or processes (β = 0.248, p = .087). Implications for the development of interventions aiming at fostering positive attitudes towards eco-innovation among the targeted enterprises are discussed.
Impulsivity, Gambling-Related Cognitions, Cognitive Reappraisal and Gambling Behaviour in a Malaysian Sample
Authors: Tan Gillian Shu Lin , Tam Cai Lian 
Published: August 2023

AbstractThe relationships between cognitive reappraisal and problem gambling have been widely studied in different contexts. However, previous research findings remain inconsistent. This discrepancy might be attributed to the effects of interactions between cognitive reappraisal and other risk factors for problem gambling. Using moderation models, this study examined the association between impulsivity, gambling-related cognitive distortions, cognitive reappraisal and problem gambling in a sample of Malaysian gamblers. A total of 149 community gamblers (103 males, 46 females; mean age = 32.18) completed an online questionnaire. Problem gambling was measured with the South Oaks Gambling Screen (SOGS); cognitive reappraisal was measured using the Emotion Regulation Questionnaire-Cognitive Reappraisal Subscale (ERQ-CR); impulsivity was measured with the Short-UPPS-P Impulsive Behaviour Scale (SUPPS-P); and gambling-related cognitive distortions were measured using the Gambling Related Cognitions Scale (GRCS). The results revealed impulsivity and gambling-related cognitive distortions as significant predictors of problem gambling. At high levels, impulsivity and cognitive distortions are significant moderator variables that strengthen the association between cognitive reappraisal and problem gambling. These findings demonstrate that reappraisal skills could exacerbate problem gambling severity amongst impulsive or self-deceptive gamblers. Future research with larger and more representative samples is needed to validate and generalise these findings.