bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mean corpuscular haemoglobin concentration and outcomes in heart failure with preserved ejection fraction
Authors: Choy Manting , Zhen Zhe , Dong Bin , Chen Cong , Dong Yugang , Liu Chen , Liang Weihao , Xue Ruicong 
Published: January 2023

AbstractAimsThis study aims to evaluate the prognostic value of mean corpuscular haemoglobin concentration (MCHC) on clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).Methods and resultsWe analysed HFpEF participants from the Americas in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with available baseline data (n = 1747). Patients were grouped into hypochromia or non‐hypochromia group according to a MCHC cut‐off level of 330 g/L. Cox proportional hazard model was used to explore the prognostic value of hypochromia on the long‐term clinical outcomes (the primary endpoint [composite of cardiovascular mortality, HF hospitalization and aborted cardiac arrest], any‐cause and HF hospitalization, all‐cause and cardiovascular mortality). Patients were further stratified according to baseline estimated glomerular filtration rate (eGFR) to explore the impact of renal dysfunction on the prognostic value of hypochromia. Baseline hypochromia was prevalent (n = 662, 37.9%) and strongly associated with worse clinical outcomes. In patients with worse renal function (eGFR < 60 mL/min per 1.73 m2), hypochromia was independently associated with primary endpoint (hazard ratio [HR], 1.56; 95% confidence interval [CI], 1.23–1.98; P < 0.001), any‐cause hospitalization (HR, 1.43; 95% CI, 1.20–1.71, P < 0.001) and HF hospitalization (HR, 1.40; 95% CI, 1.07–1.84; P = 0.015), whereas no significant association between hypochromia and these outcomes was found in patients with better renal function.ConclusionsAmong HFpEF patients, hypochromia (i.e. MCHC ≤ 330 g/L) is independently associated with adverse clinical outcomes, especially when in the presence of co‐morbidity renal dysfunction.
Metal Catalyzed Polymerization: From Stereoregular Poly(α‐olefins) to Tailor‐Made Biodegradable/Biorenewable Polymers and Copolymers
Authors: Capacchione Carmine , Grisi Fabia , Lamberti Marina , Mazzeo Mina , Milani Barbara , Milione Stefano , Pappalardo Daniela , Zuccaccia Cristiano , Pellecchia Claudio 
Published: January 2023

AbstractMetal catalyzed polymerizations are among the most important chemical reactions, accounting for the production of about 400 million tons per year of polymeric materials, 50 % of which are polyolefins. The CIRCC research units at the University of Salerno, founded by the late Professor Adolfo Zambelli, a coworker of Giulio Natta and a pioneer in the studies of stereospecific polymerization catalysts, has a consolidated expertise in this field. Although often considered a “mature” area of research, olefin polymerization catalysis continues to drive great interest of both industrial and academic scientists. On the other hand, strong political and economic pressure toward the development of “green” and possibly biodegradable alternatives to olefin‐based polymers stimulated our group to direct increasing research efforts in the area of sustainable polymers. In this perspective, we focus on the most recent work from the CIRCC research units involved in homogeneous catalysis for polymerization of a variety of monomers, with the aim to address how the concepts and the expertise developed for olefin polymerization can be applied to the development of different metal‐catalyzed polymerizations and copolymerizations. Of course, although the results are discussed in the frame of the most important literature contributions, a comprehensive review of such a wide and diversified topic is out of the scope of the paper. References to reviews covering the different types of metal catalyzed polymerizations are provided in each chapter.
[2+2] Cycloadditions of Methylene exo‐Glycals: Synthesis of Glycopyranosylidene‐Spiro‐Azetidine‐2‐ones (β‐Lactams) and Cyclobutanones
Authors: József János , Somsák László , Tóth Marietta , Juhász László 
Published: January 2023

Abstract[2+2] Cycloadditions of methylene exo‐glycal derivatives with chlorosulfonyl isocyanate and dichloroketene were studied in detail, investigating the effect of the carbohydrate moiety, protecting groups as well as reaction temperature on the yields of the transformations. These reactions gave new anomeric spiro‐β‐lactam and spiro‐cyclobutanone derivatives, whose structure was established by 1D and 2D NMR and MS experiments. The transformation of spiro‐cyclobutanone into spiro‐γ‐lactone was also demonstrated.
Frequency of and factors associated with antiseizure medication discontinuation discussions and decisions in patients with epilepsy: A multicenter retrospective chart review
Authors: Terman Samuel W. , Slinger Geertruida , Koek Adriana , Skvarce Jeremy , Springer Mellanie V. , Ziobro Julie M. , Burke James F. , Otte Willem M. , Thijs Roland D. , Braun Kees P. J. 
Published: January 2023

AbstractObjectiveGuidelines suggest considering antiseizure medication (ASM) discontinuation in patients with epilepsy who become seizure‐free. Little is known about how discontinuation decisions are being made in practice. We measured the frequency of, and factors associated with, discussions and decisions surrounding ASM discontinuation.MethodsWe performed a multicenter retrospective cohort study at the University of Michigan (UM) and two Dutch centers: Wilhelmina Children's Hospital (WCH) and Stichting Epilepsie Instellingen Nederland (SEIN). We screened all children and adults with outpatient epilepsy visits in January 2015 and included those with at least one visit during the subsequent 2 years where they were seizure‐free for at least one year. We recorded whether charts documented (1) a discussion with the patient about possible ASM discontinuation and (2) any planned attempt to discontinue at least one ASM. We conducted multilevel logistic regressions to determine factors associated with each outcome.ResultsWe included 1058 visits from 463 patients. Of all patients who were seizure‐free at least one year, 248/463 (53%) had documentation of any discussion and 98/463 (21%) planned to discontinue at least one ASM. Corresponding frequencies for patients who were seizure‐free at least 2 years were 184/285 (65%) and 74/285 (26%). The probability of discussing or discontinuing increased with longer duration of seizure freedom. Still, even for patients who were 10 years seizure‐free, our models predicated that in only 49% of visits was a discontinuation discussion documented, and in only 16% of visits was it decided to discontinue all ASMs. Provider‐to‐provider variation explained 18% of variation in whether patients discontinued any ASM.SignificanceOnly approximately half of patients with prolonged seizure freedom had a documented discussion about ASM discontinuation. Discontinuation was fairly rare even among low‐risk patients. Future work should further explore barriers to and facilitators of counseling and discontinuation attempts.
Key‐aggregate searchable encryption with multi‐user authorization and keyword untraceability for distributed IoT healthcare systems
Authors: Trivedi Hiral S. , Patel Sankita J. 
Published: January 2023

AbstractAdopting Internet‐of‐Things (IoT) enables pervasive computing by integrating distributed healthcare infrastructures to enhance conventional medical services. Integrated healthcare systems store numerous encrypted electronic health records (EHR) on clouds that multiple users frequently access as per delegated access rights. Sharing any group of selected EHR within any group of users involving different encryption keys potentially heightens security and privacy concerns over inadvertent data leaks. This necessitates a searchable encryption mechanism in distributed IoT requiring secure multi‐user authorization and efficient searchable keys management with compact trapdoors. Contemporary state‐of‐the‐art protocols utilize large numbers of expensive encryption keys and keyword trapdoors while lacking secure multi‐user authorization and keyword untraceability on clouds. This motivates us to design a novel key‐aggregate searchable encryption protocol that jointly achieves multi‐user authorization and keyword untraceability for distributed IoT applications. Key‐aggregation reduces complexity in sharing documents by executing a stand‐alone trapdoor, while token‐based authorization allows keyword search only to legitimate data users. Additionally, secure dynamic indexing achieves keyword untraceability on clouds. Security analysis illustrates correctness and resilience against typical attacks. Performance and empirical analysis demonstrate a relative advantage in storage, communication, and computational costs while incorporating secure multi‐user authorization and keyword untraceability as additional security features.
Securitization of assets with payment delay risk: A financial innovation in the real estate market
Authors: Ma Chao , Zhang Hao , Zhao Hongbiao 
Published: January 2023

AbstractWe study a new type of securitization that deals with banks' processing time, mortgage‐receivable‐backed securities (MRBSs) issued by real estate developers. Unlike traditional mortgage‐backed securities (MBSs), the major risk of underlying assets of MRBSs is payment delay instead of default and prepayment. Using unique loan‐level data, we estimate proportional hazard models and detect factors that affect the risk of underlying assets of MRBSs, including bank characteristics, property–loan–household characteristics, local market conditions, and macroeconomic conditions. Especially, we find that the effects of house prices and loan‐to‐value ratios on MRBS risk are the opposite of those on traditional MBS risk. Based on the estimates, we simulate cash flows of an underlying‐asset pool and analyze the shortfall risk of the corresponding security tranches. We find that the securitization process imposes a natural adverse selection on the underlying assets.
A cloud‐based resource for genome coordinate‐based exploration and large‐scale analysis of chromosome aberrations and gene fusions in cancer
Authors: Wang Janet , Zheng Jeanne , Lee Elaine E. , Aguilar Boris , Phan John , Abdilleh Kawther , Taylor Ronald C. , Longabaugh William , Johansson Bertil , Mertens Fredrik , Mitelman Felix , Pot David , LaFramboise Thomas 
Published: January 2023

AbstractCytogenetic analysis provides important information on the genetic mechanisms of cancer. The Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (Mitelman DB) is the largest catalog of acquired chromosome aberrations, presently comprising >70 000 cases across multiple cancer types. Although this resource has enabled the identification of chromosome abnormalities leading to specific cancers and cancer mechanisms, a large‐scale, systematic analysis of these aberrations and their downstream implications has been difficult due to the lack of a standard, automated mapping from aberrations to genomic coordinates. We previously introduced CytoConverter as a tool that automates such conversions. CytoConverter has now been updated with improved interpretation of karyotypes and has been integrated with the Mitelman DB, providing a comprehensive mapping of the 70 000+ cases to genomic coordinates, as well as visualization of the frequencies of chromosomal gains and losses. Importantly, all CytoConverter‐generated genomic coordinates are publicly available in Google BigQuery, a cloud‐based data warehouse, facilitating data exploration and integration with other datasets hosted by the Institute for Systems Biology Cancer Gateway in the Cloud (ISB‐CGC) Resource. We demonstrate the use of BigQuery for integrative analysis of Mitelman DB with other cancer datasets, including a comparison of the frequency of imbalances identified in Mitelman DB cases with those found in The Cancer Genome Atlas (TCGA) copy number datasets. This solution provides opportunities to leverage the power of cloud computing for low‐cost, scalable, and integrated analysis of chromosome aberrations and gene fusions in cancer.
Why do employees welcome or refuse shared leadership?: A qualitative exploration through force‐field analysis
Authors: Han Soo Jeoung , Yim Jeong‐Ha , Oh Jihye , Kwon Kibum , Lee Joonghak 
Published: January 2023

AbstractWe explored the perceptions of individuals in teams (both leaders and members) regarding shared leadership in the South Korean business context, seeking a nuanced and unique understanding of shared leadership. We examined how shared leadership in team‐based structures develops and functions. Informed by the driving and restraining forces framework, we elucidate factors that facilitate and that impede shared leadership practice and implementation. The analysis uses semi‐structured interviews with seven teams that each consist of one team leader and two team members. Findings include the four essential elements of shared leadership and the identification of the driving and restraining forces for why employees and managers welcome or refuse to accept shared leadership. We present strategies for human resource development (HRD) professionals seeking to cultivate shared leadership in the South Korean context. We also discuss the study's limitations and potential directions of inquiry for future researchers.
Time trends in prevalence of p16 positivity and combined HPV/p16 positivity in a large cohort of Danish vulvar cancer patients
Authors: Rasmussen Christina Louise , Thomsen Louise T. , Baandrup Louise , Franzmann Maria Benedicte , Kjær Alexander K. , Larsen Lise Grupe , Madsen Else Mejlgaard , Salinas Nadia Margeth Villena , Schledermann Doris , Winberg Birgitte Hjelm , Ørnskov Dorthe , Waldstrøm Marianne , Kjær Susanne K. 
Published: January 2023

AbstractVulvar cancer is rare, but causes substantial morbidity in affected patients. A subset of vulvar cancers is caused by high‐risk human papillomavirus (hrHPV), which primarily exerts its oncogenic effect through upregulation of tumor suppressor protein p16. Tumors positive for both hrHPV and p16 (double positive) are assumed to be HPV‐driven, but only few large studies have investigated the combined prevalence of hrHPV and p16 positivity in vulvar cancer over time. In this Danish cross‐sectional study, we assessed the prevalence of p16 positivity and double positivity for hrHPV and p16 in a large sample of vulvar squamous cell carcinomas (VSCCs) diagnosed during 1990 to 2017. In a nationwide register, we identified VSCCs from 13 hospitals across Denmark, and collected archival tumor tissue for hrHPV testing with INNO‐LiPA and immunohistochemical p16 staining. We calculated the prevalence of hrHPV, p16 positivity and double positivity according to time, age and histological subtype and evaluated time trends through estimated annual percentage changes. We included 1278 VSCCs. Overall, 35.0% (95% confidence interval [CI]: 32.4‐37.6) were positive for p16 and 31.0% (95% CI: 28.4‐33.5) were positive for both hrHPV and p16. The prevalence of p16 positivity and double positivity increased over time, both in women aged ≤59 and ≥60 years. The double positive prevalence was higher in nonkeratinizing (60.7%) and warty/basaloid VSCCs (67.5%) than in keratinizing (16.1%) and verrucous VSCCs (5.0%). These results indicate that approximately one‐third of vulvar cancers were caused by hrHPV infection, supporting a substantial preventive potential of the HPV vaccine.
Inattention and the impact of monetary policy
Authors: An Zidong , Abo‐Zaid Salem , Simon Sheng Xuguang 
Published: January 2023

SummaryWe measure aggregate inattention as the common component in agents' inattentiveness to many economic variables. Applying this measure to the US Survey of Professional Forecasters enables us to establish the following empirical evidence. Professional forecasters update their information sets every 5 months on average but do so more frequently in response to high inflation and unemployment, as well as rising market volatility and policy uncertainty. Monetary policy shocks have larger real effects when the degree of inattention is higher. To explain our empirical findings, we propose a general equilibrium model with state‐dependent information rigidity in both the production and household sectors.
The association among insomnia symptom severity, comorbid symptoms, and suicidal ideation in two veteran cohorts meeting diagnostic criteria for insomnia disorder
Authors: Kramer Emily B. , Gaeddert Laurel A. , Jackson Christine L. , Hostetter Trisha A. , Forster Jeri E. , Nazem Sarra 
Published: January 2023

AbstractObjectiveExamine the association between insomnia symptom severity and suicidal ideation (SI), after adjusting for clinical comorbidity in veterans meeting diagnostic criteria for insomnia disorder.MethodsSecondary data analyses of psychometrically validated baseline assessments of depression, posttraumatic stress disorder (PTSD), and anxiety symptoms from two online insomnia intervention randomized clinical trials (n = 232; n = 80) were conducted. Multiple linear regression was used to determine the association between insomnia symptom severity and SI, after controlling for clinical comorbidity and demographics.ResultsInsomnia symptom severity was significantly correlated with comorbid depression, PTSD, and anxiety symptoms in both cohorts and significantly correlated with SI in one. After controlling for demographics and clinical comorbidity, insomnia symptom severity was not significantly associated with SI in linear regression models.ConclusionFindings extend insomnia‐suicide research by providing evidence that insomnia symptom severity may not confer a unique risk for SI above comorbid mental health symptoms in veterans meeting diagnostic criteria for insomnia disorder.
John Henryism Active Coping and COVID‐19 policy compliance
Authors: Sullivan Jas M. , Harman Moriah 
Published: January 2023

AbstractThe aim of this paper is to examine whether the way one copes with stressful situations, as measured by John Henryism Active Coping (JHAC), influences behavioral responses to the pandemic, such as whether they engaged in mask wearing, social distancing, and hand washing. The data for this study come from the 2020 Blair Center Poll, which was conducted by the Blair Center of Southern Politics and Society at the University of Arkansas. Results show that high JHAC had a significant effect on COVID‐19 policy compliance. Additionally, there was an interaction effect between JHAC and race on COVID‐19 policy compliance. This effect was significant for only African Americans and Hispanics—not Whites. In other words, among African Americans and Hispanics, high JHAC had a significant effect on their compliance with COVID‐19 policies. These findings suggest that coping structures policy compliance during the COVID‐19 pandemic.
Improving collagen processing towards a greener approach: current progress
Authors: Mohamad Razali Umi Hartina , Ya'akob Harisun , Sarbon Norizah Mhd , Zainan Nur Hidayah , Dailin Daniel Joe , Zaidel Dayang Norulfairuz Abang 
Published: January 2023

AbstractThe high market demand for collagen as a biomaterial has prompted additional studies into improved methods of collagen extraction without sacrificing the overall quality of collagen. The use of clean technology for sustainable collagen extraction has recently gained popularity due to its efficiency and minimal waste production. This review focuses on improving collagen processing based on three essential steps: pre‐treatment (fermentation, high shear mechanical homogenisation, ultrasound), extraction (ultrasound‐assisted extraction, microwave‐assisted extraction, physical‐aided extraction, and supercritical fluid technology), and recovery (ultrafiltration). This review also summarises the benefits and drawbacks of the emerging green technologies used in each step to obtain collagen. This study shows that these clean technologies eliminate the need for excessive chemicals and shortens processing time. However, each collagen‐processing step must be carefully controlled to preserve structural integrity, which influences collagen's properties and hence its uses for further applications. © 2023 Society of Chemical Industry (SCI).
Long‐term ANT‐DBS effects in pilocarpine‐induced epileptic rats: A combined 9.4T MRI and histological study
Authors: Xu Ke , Xie Pandeng , Deng Jiahui , Tang Chongyang , Wang Xiongfei , Guan Yuguang , Zhou Jian , Li Tianfu , Liang Xiaohang , Jing Bin , Gao Jia‐Hong , Luan Guoming 
Published: January 2023

AbstractDeep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) appears to be effective against seizures in animals and humans however, its therapeutic mechanisms remain elusive. This study aimed to combine 9.4T multimodal magnetic resonance imaging (MRI) with histology to investigate the longitudinal effects of long‐term ANT‐DBS in pilocarpine‐induced epileptic rats. Status epilepsy (SE) was induced by LiCl‐pilocarpine injection in 11 adult male Sprague–Dawley rats. Four weeks after SE, chronic epileptic rats underwent either ANT‐DBS (n = 6) or sham‐DBS (n = 5) surgery. Electroencephalography (EEG) and spontaneous recurrent seizures (SRS) were recorded for 1 week. The T2‐weighted image and images from resting‐state functional MRI (rs‐fMRI) were acquired at three states: before SE, at 4 weeks post‐SE, and at 5 weeks post‐DBS. Volumes of the hippocampal subregions and hippocampal‐related functional connectivity (FC) were compared longitudinally. Finally, antibodies against neuronal nuclei (NeuN) and glial fibrillary acidic proteins were used to evaluate neuronal loss and astrogliosis in the hippocampus. Long‐term ANT‐DBS significantly reduced seizure generalization in pilocarpine‐induced epileptic rats. By analyzing the gray matter volume using T2‐weighted images, long‐term ANT‐DBS displayed morphometric restoration of the hippocampal subregions. Neuronal protection of the hippocampal subregions and inhibition of astrogliosis in the hippocampal subregions were observed in the ANT‐DBS group. ANT‐DBS caused reversible regulation of FC in the insula‐hippocampus and subthalamic nucleus‐hippocampus. Long‐term ANT‐DBS provides comprehensive protection of hippocampal histology, hippocampal morphometrics, and hippocampal‐related functional networks.
Disrupted vision impairs force steadiness and accuracy in chronic ankle instability patients
Authors: Lee Hyunwook , Han Seunguk , Son S. Jun , Seeley Matthew K. , Hopkins J. Ty 
Published: January 2023

AbstractThe primary purpose of this study was to examine the effect of visual disruption on submaximal force steadiness and accuracy among three groups including chronic ankle instability (CAI) patients, lateral ankle sprain copers, and healthy controls. Twenty patients with CAI, 20 copers, and 20 matched‐healthy controls volunteered to participate in the study. Submaximal force steadiness and accuracy for evertors, invertors, and hip abductors (10% and 20% of their maximal voluntary isometric contraction) were measured with an isokinetic dynamometer. All groups performed the tasks with and without stroboscopic glasses. The CAI group showed worse steadiness and accuracy in evertors with visual disruption compared to nonvisual disruption (p < 0.0001 and = 0.02, respectively). Relative to the control group, the CAI group showed worse force steadiness and accuracy in evertors (p < 0.0001, both), worse force accuracy in hip abductors (p = 0.02), and the coper group also showed worse accuracy in evertors (p = 0.02). Individuals with CAI demonstrated impaired force steadiness and accuracy in evertors and hip abductors compared to healthy controls. In addition, they tended to rely more on visual feedback during the force steadiness task than copers and healthy controls.