bluuebunny/crossref_metadata_2025_split huggingface dataset:
LncRNA NORAD/miR 202 5p regulates hepatoma cell viability, apoptosis via EGFR/PI3K/AKT signaling pathway
Authors: Wei Xiaoling , Dong Lingjun , Lei Xiubing 
Published: May 2023

Purpose: To examine the potential modulatory mechanisms of NORAD in hepatoma in vitro.
Methods: In this study, four human hepatoma cell lines (Bel7404, PLC5, HepG2, and HuH7), as well as a human immortalized Normal MIHA cell line were employed. Transfection was performed to up-or down-regulate NORAD and miR-202-5p expression in cells. RT-qPCR was used to measure expressions of NORAD, miR-202-5p, and biomarkers for cell cycle and apoptosis in HCC cell lines. CCK-8, Flow Cytometry for apoptosis and cell cycle arrest and Western blot experiments were performed to determine cellular viability, cell cycle arrest and apoptosis and related protein expressions. Bioinformatics tool was used to find possible binding sites on NORAD and miR-202-5p, which were further validated by dual-luciferase reporter gene assays.
Results: NORAD adversely modulated miR-202-5p in hepatoma cells and mediated cell viability, apoptosis and cell cycle arrest through regulatingmiR-202-5p. Functional experiments revealed that downregulation of NORAD or upregulation of miR-202-5p suppressed cell viability and inhibited apoptosis and cell cycle arrest. Silenced NORAD regulated the EGFR/PI3K/AKT pathway via enhancing miR-202-5p expression in HCC cell lines.
Conclusion: NORAD interaction with miR-202-5p mediated the EGFR/PI3K/AKT network.
Nghiên cứu kết quả điều trị ối vỡ sớm ở thai phụ mang thai đủ tháng
Authors: Lê Trị Trang , Trần Doãn Tú , Nguyễn Thị Kim Anh 
Published: May 2023

Mục tiêu: Khảo sát đặc điểm lâm sàng, cận lâm sàng ối vỡ sớm ở thai phụ mang thai đủ tháng và các yếu tố liên quan. Đánh giá kết quả xử trí ối vỡ sớm ở đối tượng trên.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang gồm 173 thai phụ được chẩn đoán ối vỡ sớm đến sinh tại Bệnh viện Trường Đại học Y - Dược Huế trong khoảng thời gian từ tháng 6/2021 đến 5/2022. Khảo sát các đặc điểm lâm sàng, cận lâm sàng xuất hiện khi vào viện và trong quá trình theo dõi tại bệnh viện liên quan đến ối vỡ sớm. Đánh giá kết quả xử trí gồm thời điểm, phương pháp chấm dứt thai kỳ và các biến chứng trên mẹ và con.
Kết quả: 93,1% thai phụ có thời gian ối vỡ đến viện dưới 6 giờ. Chỉ số Bishop > 5 điểm 79,8%. Nước ối xanh 23,1%. Siêu âm lúc vào viện: thiểu ối 24,3%, trọng lượng thai ≥ 3500 gram 19,7%. CTG lúc vào viện và trong quá trình theo dõi nhóm 1 chiếm tỷ lệ cao nhất. 69,4% bạch cầu dưới 12.000/mm3. Xử trí khi vào viện: Mổ lấy thai (12,7%), theo dõi chuyển dạ tự nhiên (49,1%), truyền Oxytocin (19,7%), vê vú (18,5%). 73,5% có thời gian bắt đầu truyền Oxytocin sau vỡ ối từ 6 - 12 giờ. Thời gian chuyển dạ đến sinh đường âm đạo của nhóm được thúc đẩy chuyển dạ ngắn hơn nhóm theo dõi chuyển dạ tự nhiên khoảng 2 đến 3 giờ. 39,9% có thời gian trung bình ối vỡ đến khi kết thúc thai kỳ < 6 giờ. Biến chứng mẹ: Nhiễm trùng ối 3,5%, băng huyết sau sinh 5,8%. Chưa ghi nhận biến chứng con sau sinh. Trọng lượng thai ≥ 3500 gram có tỷ lệ mổ lấy thai cao (p < 0,05). Thai phụ được thúc đẩy chuyển dạ truyền Oxytocin và được sử dụng kháng sinh dự phòng chủ yếu có thời gian gian ối vỡ đến khi kết thúc thai kỳ > 12 giờ (p < 0,05).
Kết luận: Ối vỡ sớm trên thai đủ tháng có tỷ lệ nhiễm trùng ối thấp. Thúc đẩy chuyển dạ giúp rút ngắn thời gian chuyển dạ đến sinh ngã âm đạo.
Effects of Ethephon treatments on Ripening and Uniformity of Fig Fruit (Ficus carica. L)
Authors: مرعي محمود عبدالله  , إدريس أحمد الجهاني  , إدريس عبدالعزيز الطويل  
Published: May 2023

The current experiment was carried out to determine the effect of the application of ethephon on the maturation of “Peter” figs. Fig fruits were treated with three aqueous concentrations of ethephon (500, 1000, and 1500 ppm) during the developmental stage. The physic-chemical characteristics, such as fruit weight, fruit length, fruit diameter, total soluble solids (TSS), and fruit acidity were recorded and analysed. The results showed that ethephon application during the developmental period of the fig fruits significantly accelerated fruit ripening and enhanced the fruits’ uniformity. Fig fruits treated with ethephon showed increased TSS compared to untreated fruits, and the acidity of the treated fruit decreased compared to that of untreated fruits. Additionally, TSS/ acidity ratio was significantly higher in 1500 ppm treatment in comparison with other treatments. On the basis of our data, we conclude that the application of ethephon to fig fruit increases ripening and uniformity of the fruit.
Integrated Effect of Fertilizers on Soil pH, EC and Organic Matter Content
Authors: حسين عبدالسلام مخلوف  , حسن  عبدالمولي محمد  , جمعه احمد لبيب  , مفتاح علي امحمد  
Published: May 2023

Two field experiments in split-plot design were carried out in the winter season of 2014-2015 at Mansoura University Farm, Egypt, to investigate the effect of biochar, compost, and chicken manure with different rates of mineral fertilization on soil pH, EC, and organic matter content. Treatments of organic were biochar, compost, and chicken manure, while the studied mineral fertilizer treatments (NPK) took with rates of 50,75,100, and 125 %. The obtained results can be summarized in; biochar, addition led to an increase in the pH of wheat (Sakha 68) soil by 8.73 %, compost, and chicken manure decreased the pH of wheat soil by 8.30 and 8.19% compared with 0.0 organic addition, where the same amendment with the same order increased pH of barley (Gemmiza 123) soil by 8.65, and reduce with 8.30 and 8.18% of compost and chicken manure. Biochar, compost, and chicken manure treatments increased values of EC 2 , 2.43, and 2.10 dS m-1 of wheat soil and 2.80, 2.23, and 2.14 dS m-1 of barley, respectively. Organic matter improved and the highest result was found with chicken manure 2.798 and 2.767 % of wheat and barley soil. Mineral fertilizer decreased both pH of wheat and barley soil as well as increased EC and organic matter up to the highest level used. A significant organic fertilizer type - mineral fertilization dose interaction was found with the most of tested treatments. The highest effect on pH in soil paste was found in the interactions between biochar with mineral treatments compared to other treatments of both wheat and barley soil. The best mean value of EC was recoded with the interaction between compost and 100 % NPK treatment (2.76 dS m-1) of wheat soil, a similar trend was also achieved with barley soil (3.29 dS m-1). Chicken manure -125 % of recommended NPK treatment gave the heights values of wheat and barley organic matter content, 2.798 and 2.767 %. Respectively.
Prediction of Wave Localization in 2D Disordered Vibrating Systems
Authors: Lefebvre Gautier 
Published: May 2023

As a general physical phenomenon, localized waves have been studied in optics, electromagnetism, acoustics and many physical domains. Strong or Anderson localization and weakly localized waves have special attention in optics and in quantum mechanics, due to the disordered media, but also can be found in mechanical waves.In this seminar, I will present results about several systems displaying wave localization in the field of vibrations. When the localization is produced by complex boundary conditions, the landscape of localization theory allows to predict the position and frequency of the localized modes. Experimental results demonstrate that it is possible to obtain this information from a simple static deformation measurement, without knowing precisely the details of the geometry or physical properties [1,2]. Another way to stimulate localization is to create a dense assembly of scatterers, or use a quasi-periodical structure. We investigate localization properties of an elastic plate with closely disposed non-through holes, as resonating scatterers. The measurement of the wavefield in the full plate and the scatterers themselves reveals specific properties of the localized modes.
Factors contributes to overweight and obesity among young adults
Authors: Elfaki Badria A 
Published: May 2023

Background: Obesity is a major public health problem in both developed and developing countries and it became an important public health problem in developing countries like Sudan. Study purpose: The purpose of this study was to identify obesity and overweight and determine factors that contribute to obesity and overweight among young adults. Methods: A descriptive quantitative study was conducted in Sudan, Khartoum. The sample size was amounted to 180 collected with convenient techniques and selected according to criteria. Data was obtained through a self-administered questionnaire and was analyzed by (SPSS) version 22.0, descriptive statistics, cross tabulation were made. Results: 103 (57.2%) of participants were females and 77 (42.8%) were males. Most of the participants' 90(50.0%) ages ranged from 18–23 years. More than half of participants, 104 (57.7%) with university and post-university education, and 54.4% had an average monthly income. Obesity and obesity were 13.9% and 22.2%, respectively. Obesity was insignificantly high among females (15.5%), and overweight was higher among males (23.4%), a p-value of 0.860. Obesity and overweight are caused by a variety of factors, including hereditary and eating foods containing fat, cholesterol, and sodium.
Salihli Kazak Türklerinin Atasözleri Üzerine Metaforik Bir İnceleme: Hayvan Metaforları
Authors: AYDOĞAN Betül 
Published: May 2023

Bu çalışmada Manisa’nın Salihli ilçesinde yaşayan Kazak Türklerinin atasözlerindeki kaynağını hayvan adlarından alan metaforlar analiz edilmiştir. Hayvan adlarıyla işaret edilmek istenen kavramlar ortaya konularak bir kavramsal alan oluşturulmaya, bir zihin haritası çıkarılmaya çalışılmıştır.
Atasözleri, bir toplumun yüzyıllar boyunca edindiği tecrübe ve gözlemlerini yansıtan; onların duygu, düşünce, inanç, değer, davranış birikimlerini kuşaktan kuşağa aktaran metaforik yapılardır. Bu metaforik yapılarda hayvan metaforlarına sıkça rastlanılmaktadır. Bu çalışmada Salihli Kazak Türklerinin hayvan davranışları ile insan davranışları ve hayvan davranışları ile nesneler arasında kurdukları ilişkiden yola çıkılmıştır. Böylece onların ve atalarının kavram dünyasına, düşünce yapısına dair ipuçlarının elde edilmesi amaçlanmıştır.
Çalışma; planlama, derleme ve inceleme aşamasından oluşmaktadır. Görüşme ve kılavuz kişiden yararlanma tekniği ile 192 atasözü derlenmiştir. Derlenen atasözlerinde metafor olarak kullanılan 32 hayvan adı tespit edilmiş. Tespit edilen hayvan metaforları, George Lakoff ve Mark Johnson’ın Kavramsal Metafor Kuramı çerçevesinde incelenmiştir. Bu kurama ait olan kavramsal haritalama yöntemi ile kaynak alandaki hayvanların hedef alanda hangi kavramlarla eşleştirildiği analiz edilmeye çalışılmıştır. Analiz sonucunda Salihli Kazak Türklerinin ait oldukları topluma, kültüre ve konuştukları dile özgü tasavvurlarının, duygu değerlerinin neler olduğu ortaya konulmuştur.
Köl Tegin Yazıtı’ndaki Salçı Sözcüğü Üzerine
Authors: AYDIN Erhan 
Published: May 2023

Türklerde at ile ilgili ilk Türkçe kaynaklar, doğal olarak Türk runik harfli eski Türk yazıtlarıdır. Bu yazıtlarda at sözcüğü ve buna bağlı birçok türev tespit edilmiş olsa da esasen atları konu edinen metin, kuşkusuz Köl Tegin Yazıtı’dır. Ağabeyi Bilge Kağan tarafından metni oluşturulup diktirildiği bilinen Köl Tegin Yazıtı’nın doğu yüzünün 40. satırı ile kuzey yüzünün 2, 2 ve 3. satırında tespit edilen ve şalcı, şalci, şalçı, şalçi gibi türlü biçimlerde okunan bu ad, kimilerince atın sahibi, kimilerince ise atın adı olarak değerlendirilmiştir.
Bu makalenin ilk bölümlerinde dört kez geçen sözcüğün, yazıt üzerinde çalışanlarca nasıl okunup anlamlandırıldığına yer verilmiş; ardından sözcüğün orta Moğolcanın önemli kaynakları Moğolların Gizli Tarihi ve Defter-i Çingiz-nâme’de de geçtiği biçimle karşılaştırılarak Türkçe sal ‘sal’ ve isimden isim yapan +çI eki ile kurulmuş ve ‘salcı’ anlamında olabileceği önerilmiştir. Sözcüğün Moğolca ve Türkçe metinlerinde geçen biçimleri üzerinde de durulmuştur. Makalenin değerlendirme bölümünde ise Türkçe salçı sözcüğünün Moğolistan’ın batı taraflarında, Kırgızistan’da bir yer olabileceği ve dolayısıyla da, Köl Tegin yazıtı temelinde, bozkırda yaşayan Türklerin, uzak diyarlara sefer yaparken o bölgenin atlarına bindiği ve saldırdığı görüşüne yer verilmiştir. En azından kuzey ve batı seferlerinde binilen atlar verilmek suretiyle, binlerce kilometrelik bölgelere sefere çıkılırken Moğolistan’daki kısa boylu atlarına değil, sefer edilen bölgenin atlarına binilmiş olabileceği ve dolayısıyla da Türkçe salçı sözcüğünün bir yer adı olabileceği öne sürülmüştür.
ENGLISH FOR RESEARCH AND PUBLICATION PURPOSES: TRENDS AND PERSPECTIVES IN DEVELOPMENT
Authors: Савицкая Э.С. 
Published: May 2023

В статье рассматривается феномен английского языка для научно-публикационных целей (ERPP) в составе академического английского; определяются универсальные академические навыки и умения и специфические умения для обеспечения практики в области международных публикаций. Поясняется социальная актуальность курса английского языка для научно-публикационных целей. Проводится анализ исследований в области преподавания английского языка для научно-публикационных целей, систематизируются хорошо изученные аспекты – обучение жанрам академических текстов, развитие навыков и умений академического письма – и недостаточно исследованные вопросы. К ним относятся навыки общения с редакцией журналов и знакомство с редакционной политикой. Автор освещает тенденции развития академического английского в вузе, среди которых использование электронных средств обучения для самокоррекции и автономного обучения.
The article focuses on teaching practice of English for research publication purposes (ERPP) as part of Academic writing course. The author distinguishes universal academic writing skills and specific skills for publishing research results in international journals. A brief overview of topical issues explains actual demand of the course. Currently, the theory of ERPP teaching practice is well developed in such areas as teaching academic texts genres and academic writing skills. The article illustrates the areas with insufficient studies as well, i.e. the experience of academic correspondence with an editor and the knowledge of journal publication policy. The author makes a review of trends and perspectives in ERPP theory development, with online teaching tools on the focus.
A Lateral Cephalometric Radiographic Analysis of Size and Shape of Sella Turcica: A Retrospective Observational Study
Authors: Madamala Suvarna Lakshmi , Ramesh Tatapudi , Reddy Reddy Sudhakara , Jyothirmai Koneru , Beeraboyina Anand Babu , Gadadasu Swathi 
Published: May 2023

Objectives: To assess shape and size of Sella turcica on lateral cephalographs, and to find association of age and gender with shape and size of sella turcica.
Methods: Lateral cephalographs of 434 healthy subjects (254 females and 180 males) in the age group of 8-30 years were included in the study. Linear dimensions of sella turcica (length, depth, diameter) were measured and different shapes of sella (Normal, oblique anterior wall, bridging, double contour of floor, irregular dorsum, pyramidal) were analyzed. Student’s t-test to calculate mean differences in linear dimensions with age and gender. Frequency distribution of shape analyzed through chi-square test. Inter and intra observer variability assessed through paired t- test.
Results: Normal shape of sella turcica was most common shape (52.5%). Linear dimensions were increased with age (p>0.05) and except for diameter, length and depth were greater in males compared to females (p>0.05). When intra and inter observer variability was assessed, high significant values obtained with respect to depth (p=0.000).
Conclusion: This study concluded that regardless of age and gender, normal shape of sella turcica (52.5%) was most common shape followed by sella turcica bridging (21.9%). Mean linear dimensions of sella turcica increased with age. Length and depth dimensions were larger in males comparative to females. This study provides baseline data for further research and clinical practice in fields of forensic medicine and epidemiology.
Strengthening Literacy: Assistance by the AKMI Service Team 2022
Authors: Maimon Sumo  , Mansur Moh. , Hidayat Taufiq 
Published: May 2023

Abstrak: Pelaksanaan pengabdian ini bertujuan adalah melatih dan mendampingi, kepala madrasah, Guru kelas 5 MI di Kabupaten kediri Jawa Timur dalam menerapkan dan penguatan empat literasi yaitu literasi Membaca, literasi, numerasi, sains dan literasi Sosial Budaya yang berbasais Asesmen Kompetensi madrasah Indonesia (AKMI). Adapun sasaran program ini adalah Madrasah yang sudah di beri bimtek oleh kementerian Agama dan siswanya sudah melakukan Tes AKMI dan ANBK. Metode yang digunakan dalam kegiatan pengabdian ini adalah wawanara dan evaluasi instrumen hasil kegiatan yaitu Raport AKMI untuk Siswa dan wawancara untuk Kepla madrasah, guru kelas V MI serta Tenaga kependidikan lainnya. Kegiatan ini dilaksanakan dalam dua tahap, yaitu: (1) Pendampingan kepada guru dan Siswa dalam program penguatan Literasi (2) pelaksanaan dan Evaluasi hasil pendampingan. Hasil wawancara dengan para guru dan kepala Madrasah MI bahwa mereka memahami tentang: 1) cara membaca Raport Hasil Tes Diagnostik AKMI, 2) Ada Upaya meningkatkan kompetensi Peserta Didik berdasarkan leverl mereka.
Kata Kunci: Asesmen Kompetensi Madrasah Indonesia (AKMI), Penguatan program literasi
Spiritual Strengthening Through Religious Development in Potoan Daja Village, Palengaan Pamekasan
Authors: Mukit Abdul , Arifin Zainal , Yakin Nurul , Mubarok Sabiqul , Iqbal Moh 
Published: May 2023

In today's era, humans are facing increasingly complex life challenges. For that, a strong religious foundation is needed. The research aims to strengthen religion through the congregational prayer movement in Potoan Daja Village, Palengaan Pamekasan. Religion is a treatise conveyed by God to the Prophet as a guide for humans and perfect laws to be used for humans in carrying out real life procedures and regulating relationships with responsibility to Allah, to society and the natural surroundings.
The methodology used is mixed methods, namely a combination of literature and field studies. Where the literature study is carried out to formulate the theory, while field studies are carried out through direct observation of the location of the object of study.
The findings of this study are that the Religious Guidance Through the Congregational Prayer Movement conducted in Potoan Daja Village is highly appreciated by the community and directly increases religious and religious awareness. Activities to Strengthen Religious Development through the Congregational Prayer Movement in Potoan Daja Village, Palengaan Pamekasan have succeeded in fostering a new prayer room at the residence of Mr. Muhammad Bhere' Sabe with two male and female shafs through the preparation of the main and supporting programs using the lecture and story method.
Georgetown Eye Health Initiative
Authors: Linson Elyse , Zanganeh Tatiana , Korchak Michael , Lustbader Jay 
Published: May 2023

As diseases that affect vision become increasingly prevalent, access to vision screenings will become more important. The inhabitants of D.C. General Family Shelter, a homeless shelter in Southeast Washington, D.C., have limited access to primary care, let alone vision care. Educational strategies to improve this disparity provide students the opportunity to develop the attitudes, knowledge, and skills necessary for providing a needed service for underserved patients. Medical students, resident physicians, and faculty of Georgetown University School of Medicine, MedStar Georgetown University Hospital, and MedStar Washington Hospital Center created the Georgetown Eye Health Initiative (GEHI) to provide an opportunity for students to participate in vision and eye health screening clinics for the underserved and homeless. The establishment, missions, and protocol of GEHI as a functional and educational clinic are described, as well as challenges encountered and future directions. Medical students, residents, and faculty working in collaboration can provide increased access to vision screening and eye health education for the medically underserved. With a focus on community engagement and education, ophthalmology represents a specialty area that has been previously overlooked in student-run clinics and has a significant role at the forefront of preventative care.
Foot Exams in a Student-Run Clinic
Authors: Steinman Jeremy , Wosiski-Kuhn Marlena , Haddad Devin , Ramos John , Callahan Kathryn E 
Published: May 2023

Background: Chronic diabetes management is challenging in any clinic. A quality improvement study addressed the barriers affecting diabetic foot examination rates in a student-run clinic. Methods: Between February 1, 2013 and December 31, 2015, providers received education about exam components and reminders to perform the exam. Two reminder phases were implemented: 1) inked stamps in the chart and 2) Diabetes Care Forms (a half sheet explaining the exam and streamlining documentation). All encounters for patients with diabetes (451) were retrospectively selected from an internal database for analysis of the presence or absence of chart reminders and diabetic foot examinations. Microsoft Excel was used for basic statistical analysis and chart propagation; SAS was used for chi-square testing. Results: Pre-intervention encounters had an exam rate of 33% (43/107). During the stamp-based intervention between February 1, 2013 and January 31, 2014, the overall exam rate was 78% (86/110, p<0.0001 from baseline) and 90% with the presence of a stamp (81/90, p<0.0005 from pre-intervention). During the Diabetes Care Form (DCF) intervention between February 1, 2014 and December 31, 2015, the overall exam rate was 83% (158/191, p<0.0001 from baseline, p>0.10 from stamp intervention) and 97% for the charts with a DCF (143/148, p<0.0001 from baseline, p<0.05 from stamp intervention).Conclusions: Academic detailing and visual reminders are effective techniques to improve the rate of diabetic foot examinations. A half sheet of paper serving as documentation and as a reminder increased the rate of foot exams in a student-run free clinic with paper charts and rotating clinical staff.
Systematic Review of Patient-Centered Needs Assessments Performed by Free Health Clinics
Authors: Arenas Daniel Jose , Noche Rommell , Thomas Arthur , Hallak Dania , Raman Swathi 
Published: May 2023

Background: Free clinics, such as student-run clinics (SRCs), aim to improve healthcare for underserved populations. These populations, which include homeless individuals, low-income citizens, immigrants, and other marginalized groups, have different needs that can also vary by location. It is thus important that SRCs strive to know their patient populations. Needs assessments (NAs) are a tool to achieve this goal. To further develop NAs by SRCs, we sought to synthesize the state of published NAs by free clinics. This manuscript is meant to encourage these clinics to perform more NAs.Methods: We conducted a systematic review of manuscripts containing the concepts â€œstudent clinicâ€ and â€œneeds assessmentâ€. We searched PubMed, Embase, Scopus, Web of Science, and Google Scholar. Manuscripts were included in the review if they 1) were peer-reviewed, 2) described a free-of-charge clinic, 3) performed a NA, and 4) the NA investigated needs or concerns of patients and/or the community. NAs were defined as an approach to gather information about a patient population with the goal of improving their healthcare. Results: The initial search yielded 94 manuscripts; 18 manuscripts met inclusion criteria and were retained for full examination. The NAs showed a plethora of different purposes, methodologies, and useful results. From the analysis, we also present suggestions for future NAs.Conclusions: The existing peer-reviewed and published NAs by student-run clinics show the immense utility and potential of this tool. There is ample opportunity to publish and expand more NAs.