bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Insight into UV-induced Oxidative Stress and Role of Herbal
Bioactives in the Management of Skin Aging
Authors: Harwansh Ranjit K. , Deshmukh Rohitas 
Published: April 2023

Abstract:
Skin is a defensive barrier that protects the body against sun rays and other harmful
environmental elements. Sun rays contain ultraviolet rays, UVA (320-400 nm) and UVB (280-
320 nm), which are highly harmful to the skin, leading to photoaging. Nowadays, sunscreen
products are being utilized to protect the skin against photodamage. Conventional sunscreens are
useful but cannot provide skin protection against UV rays for a longer period of time. Therefore,
they need to be applied frequently. Aromatic compounds (ACs)-based sunscreens may filter out
the UV rays but give rise to several side effects, like premature aging, stress, atopic dermatitis,
keratinocytes (KCs) damage, genetic interruption, and malignant melanoma due to deposition of
their toxic metabolites on the skin. The concept of natural medicines has become popular
worldwide because of their safety and efficacy. Natural medicines have been proven to possess a
wide array of biological properties, including antioxidant, antityrosinase, antielastase, antiwrinkle,
antiaging, anti-inflammatory, anticancer, etc., against sun rays-mediated skin damage. The
present review article is focused on UV-induced oxidative stress, and pathological and molecular
targets with updates on herbal bioactives for the management of skin aging.
Stairway to Heaven: Do head-to-head Trials Indicate a Need for Definite
Criteria for Choosing Biologic Drugs in Rheumatoid Arthritis?
Authors: Kobak Senol 
Published: April 2023

Abstract:
Rheumatoid arthritis (RA) is a chronic disease characterized by joint and systemic involvement
that develops with different pathogenetic mechanisms. Treatment of the disease is undertaken
with disease-modifying anti-rheumatic drugs (DMARDs). The mechanisms of action of conventional
DMARDs generally are based on the inhibition of T and B-cells in the immune system. In
recent years, biologic and targeted smart molecules have been used in the treatment of RA. Targeting
different cytokines and inflammatory pathways, these drugs have ushered in a new era in RA
treatment. The efficacy of these drugs has been demonstrated in many studies; and in the postmarketing
period, that is, as the patients who use them say, they are like a “stairway to heaven”.
However, as every "road to heaven” is challenging and “thorny”, the efficacy and reliability of these
drugs and whether any one of them is superior to the others, remains a matter of debate. However,
the use of biologic drugs with or without cDMARDs, the preference for original vs. biosimilar molecules,
and discontinuation of the drugs after achieving sustained remission are other questions that
need to be explored. When it comes to the choice of biological drugs by rheumatologists, it is not
yet clear on which criteria they base their choices on. Due to the limited comparative studies of
these biological drugs, the subjective criteria of the physician gains importance. The selection of
these drugs, however, should be based on objective criteria such as efficacy, safety, superiority over
each other, and cost. In other words, the determinant of the "path to heaven" should be based on objective
criteria and recommendations according to the scientific data generated by controlledprospective
studies, not on the initiative of a single physician.

:
In this review, a head-to-head comparison of biological drugs used in the treatment of RA, their efficacy,
safety, and which are superior are discussed in light of recent literature data.
Flavonoids, Isoflavonoids and others Bioactives for Insulin Sensitizations
Authors: Goswami Kushagra , Badruddeen  , Arif Muhammad , Akhtar Juber , Khan Mohammad Irfan , Ahmad Mohammad 
Published: April 2023

Abstract:
Diabetes is a chronic condition that has an impact on a huge part of the world. Both animals and humans have been demonstrated to benefit from natural goods, and organisms (animals, or microbes). In 2021, approximately 537 million adults (20-79 years) are living with diabetes, making it the one of the biggest cause of death worldwide. Various phytoconstituent preserved β-cells activity helps to prevent the formation of diabetes problems. As a result, β-cells mass and function are key pharmaceutical targets. The purpose of this review is to provide an overview of flavonoids' effects on pancreatic β-cells. Flavonoids have been demonstrated to improve insulin release in cell lines of isolated pancreatic islets and diabetic animal models. Flavonoids are thought to protect β-cells by inhibiting nuclear factor-KB (NF-KB) signaling, activating the phosphatidylinositol 3-kinase (PI3K) pathway, inhibiting nitric oxide production, and lowering reactive oxygen species levels. Flavonoids boost β-cells secretory capacity by improving mitochondrial bioenergetic function and increasing insulin secretion pathways. Some of the bioactive phytoconstituents such as S-methyl cysteine sulfoxides stimulate insulin synthesis in the body and increase pancreatic output. The berberine increased insulin secretion in the HIT-T15 and Insulinoma 6 (MIN6) mouse cell line. Epigallocatechin-3-Gallate protects against toxicity accrued by cytokines, reactive oxygen species (ROS), and hyperglycemia. Quercetin has been proven to boost insulin production by Insulinoma 1 (INS-1) cells and also protect cell apoptosis. Overall flavonoids have beneficial effects on β-cells by prevented their malfunctioning or degradation and improving synthesis or release of insulin from β-cells.
Analysis of Cesarean Section Causes Using Robson’s Ten Group
Classification System in Selected Hospitals Affiliated to Shiraz University
of Medical Sciences: A Cross-sectional Study
Authors: Rookesh Zohreh , Zarshenas Mahnaz , Tayebi Naeimeh , Akbarzadeh Marzieh 
Published: April 2023

Background:
Robson’s Ten Group Classification System (RTGCS) is widely used to evaluate,
monitor, and compare cesarean delivery (CD) rates within and between delivery service centers.
This study aimed to investigate the causes of CD in Shiraz teaching hospitals using RTGCS.

Materials and Methods:
A cross-sectional study on 1787 pregnant women who underwent CD in selected
teaching hospitals in Shiraz, Iran, was selected via convenience sampling within 3 months. The
data collection tool was a demographic, midwifery, and fertility information questionnaire completed
through interviews and medical records. Subjects’ classification was performed based on midwifery
concepts and parameters described in RTGCS. The Robson's 10-group classification is based on simple
obstetrical parameters (parity, previous CS, gestational age, onset of labour, fetal presentation, and
number of fetuses). Data were analyzed using SPSS software and descriptive tests were used to describe
the data.

Results:
Of the 1787 subjects, 455 (25.5%) had planned CS and 1332 (74.5%) had emergency CS. The
most common causes of CD were previous CD (58.6%) and fetal distress (27.6%). Overall, 823 (46.1%)
had fetal and placental causes, 1268 (71%) had uterine causes, and 78 (4.4%) had maternal causes.

Conclusion:
The biggest factors that played a role in the CD rate in the present study were termed
multipara women with a history of previous CD. The CD rate and the overall size of this group are
still increasing, and as a result, women with a history of a previous CD must be motivated more effectively
to have a vaginal birth after cesarean delivery (VBAC).
Human Monkeypox Virus: Current State of Knowledge and Implications
for the Imminent Days
Authors: Ray Suman Kumar , Mukherjee Sukhes 
Published: April 2023

Abstract:
Monkeypox, a zoonotic orthopoxvirus, unintentionally infects humans and causes a condition
resembling smallpox with noticeably reduced fatality. Despite the name monkeypox, the virus did
not originate in monkeys. The virus has been linked to several rodents and small mammals, but the real
source of monkeypox is still unknown. It was first noticed in macaque monkeys; hence it is named
monkeypox. Although monkeypox transmission from person to person is extremely uncommon, it is
frequently linked to respiratory droplets or close contact with mucocutaneous lesions of an infected
person. This virus is indigenous to western and central Africa, with outbreaks in the Western Hemisphere
linked to the exotic pet trade and international travel, making it clinically significant. The immunization
against vaccinia virus provided coincidental immunity to monkeypox, but the eradication
of smallpox and the consequent lack of vaccination campaigns allowed monkeypox to become clinically
relevant. Even though the smallpox vaccine offers protection against the monkeypox virus, the incidence
is increasing because of newly non-immunized generations. There is currently no designated
treatment for infected individuals; however, supportive treatments are used to relieve symptoms. In
extremely severe cases, medications such as tecovirimat may be effective and are used in Europe. Because
there are no precise recommendations for symptom alleviation, many treatments are on trial.
Smallpox immunizations like JYNNEOS and ACAM2000 are also used as prophylactic measures in
the case of the monkeypox virus. This article describes the assessment and treatment of monkeypox
infections in humans and emphasizes the need for a multidisciplinary team to treat patients with this
condition and prevent disease outbreaks.
An IoT Enabled Cost Effective Smart Healthcare for Real-Time COVID-
19 Patient Early Identification and Monitoring System Using Smartphone
Authors: Shahed Md. Tanvir , Azim Meem Abda Fariha , Habib Md. Shazibul , Sen Goyur Prosad , Hossen Md. Shamim , Uddin Md. Shamim 
Published: April 2023

Introduction:
The SARS-CoV-2 virus causes COVID-19, a highly contagious disease.
Meetings between COVID-19 patients, their families, and medical professionals are no longer safe.
To meet their patients, doctors and patients' families must take extreme precautions. Even with these
stringent safety precautions, there is a chance that he or she will be affected by COVID-19. In this
context, remote patient monitoring via IoT devices can be a highly effective system for today's
healthcare system with no safety concerns.

Methods:
This paper describes an IoT-based system for remote monitoring of COVID-19 patients that
uses measured values of the patient's heart rate, body temperature, and oxygen saturation, the most
critical measures required for critical care. This device can monitor the observed body temperature,
heart rate, and oxygen saturation level in real time and can be easily synchronized with a ThingSpeak
IoT cloud platform channel for instant access through a smartphone. When the sensor value exceeds
the system's safe threshold, the system will send an email alert to the system user. Some people may
notice a decrease in oxygen saturation without any symptoms or respiratory problems. This system
can be very useful for early COVID-19 identification in this case. The proposed IoT-based technique
is based on an Arduino Uno system and has been tested and validated by a large number of human test
participants. As an example, five sample results are shown in this paper.

Results:
The system yielded promising results. When compared to other commercially available devices, the system's results were found to be accurate, with a maximum error rate of less than 5%,
which is quite acceptable. The system's data can be saved in the ThingSpeak cloud server for further
analysis. This system requires a unique email and password verification to maintain system security
and user data privacy. This patient monitoring system has grown in popularity during this COVID-19
pandemic due to its uniqueness and diverse medical applications. Many people's lives are impacted
daily when illnesses are not identified in a timely and accurate manner, denying us the opportunity to
provide medical care. To deal with such scenarios, this system will help to monitor a COVID-19 patient's specific parameters, predict the patient's status on a regular basis, and send an email alert to the
system user if something abnormal occurs.

Conclusion:
As a result, this IoT-based smart healthcare solution could help save lives during the current COVID-19 pandemic. This technology is easy to use and reduces the need for human intervention.
Prevalencia de maloclusiones en pacientes del Programa de Brigadas de Salud Bucodental de la Facultad de Odontología, UNAM. 2019
Authors: Montes de Oca Suárez Kenya Isabel , Mendoza Oropeza Laura , Cuevas Rojo Denis Anayansi 
Published: April 2023

Introducción: la Organización Mundial de la Salud (OMS) considera las maloclusiones un problema de salud pública que ocupa el tercer lugar en frecuencia dentro de las afecciones de la cavidad oral. El Programa de Brigadas de Salud Bucodental de la Facultad de Odontología de la UNAM brinda atención a las poblaciones más vulnerables de México. Objetivo: determinar la prevalencia de maloclusiones en pacientes de seis a 18 años que son atendidos en el Programa de Brigadas de Salud Bucodental de la Facultad de Odontología de la UNAM, en los estados de Tabasco, Querétaro y Chihuahua, durante el año 2019. Material y métodos: se realizó un estudio transversal en 244 pacientes de seis a 18 años; se hizo la historia clínica y exploración física con previo consentimiento informado. Resultados: de acuerdo con la clase molar, del lado derecho 119 (48.77%) pacientes presentaron clase I, 56 (22.95%) clase II y 37 (15.16%) clase III; del lado izquierdo 126 (51.64%) presentaron clase I, 45 (18.44%) clase II y 39 (15.98) clase III. Acerca de los hábitos perniciosos, se encontró que los más frecuentes son proyección lingual con 85.25% (208), seguido de mordedura de objetos con 59.84% (146), onicofagia con 54.10% (132), succión labial con 43.85% (107) y respiración bucal con 36.89% (90). Conclusiones: la prevalencia de las maloclusiones se presentó de igual manera en los tres estados de la República Mexicana. Es importante eliminar los hábitos perniciosos y comenzar un tratamiento en edades tempranas.
ATIVIDADE ANTIFÚNFIGICA DO ÓLEO DE MELALEUCA SOBRE A CANDIDÍASE ORAL: REVISÃO DA LITERATURA
Authors: Almeida Candido Emilly Francielly , Coelho Marques Marcelo Victor , Almeida Candido Giovanni Luccas , Dos Santos Vianna Néri Júlia , Borges de Lima Dantas Juliana 
Published: April 2023

A candidíase oral trata-se de uma infecção fúngica e tem como cepa predominante a Candida albicans. Este fungo é encontrado em diferentes membranas mucosas do organismo humano e quando ocorre um desequilíbrio da microbiota local, manifestam-se múltiplas lesões que podem evoluir para quadros clínicos severos. Apresenta elevada frequência em pacientes imunossuprimidos e sob uso prolongado de antibióticos e corticosteroides, e o seu tratamento padrão se baseia na utilização de compostos azóis e poliênicos. Contudo, devido à possível citoxicidade desses medicamentos associada à resistência dos microrganismos, há uma crescente busca por terapias alternativas, o que inclui o uso de fitoterápicos. O presente estudo objetivou apresentar a utilização do óleo essencial de melaleuca ou Tea Tree Oil (TTO) no manejo de infecções fúngicas em cavidade oral. A metodologia se baseou na busca inicial de artigos nas bases eletrônicas: National Library of Medicine (PubMed), Biblioteca Virtual em Saúde (BVS) e literatura cinzenta do Google Scholar, utilizando-se o cruzamento dos descritores DeCS/MeSH “melaleuca oil” AND “oral thrush”. De forma a complementar a fundamentação teórica, utilizou-se sites institucionais, além da livre busca através das referências inicalmente selecionadas. Um total de 20 trabalhos foram incluídos e os resultados demonstraram efeito satisfatório do óleo de TTO na prevenção e no tratamento da candidíase oral em cepas de Candida albicans através de estudos experimentais em modelo animal. O TTO se mostrou eficaz no manejo da candidíase oral em animais, todavia, são necessários ensaios clínicos controlados para obtenção de posologias eficazes e seguras para o paciente.
Palavras-chave: Candidíase oral, Fitoterapia, Óleo de melaluca.
Coffee entrepreneurship during COVID-19
Authors: Carreón-Guillén Javier , Bustos Aguayo José Marcos , Juárez Nájera Margarita , Hernández-Valdés Jorge , Sánchez-Sánchez Arturo , García-Lirios Cruz 
Published: April 2023

The exploration of the relationships between the determinants of entrepreneurship was the objective of this work. A non-experimental study was carried out with a non-probabilistic selection of 300 coffee farmers affiliated to the microfinance program. Is observed a structure of five factors: representations, habitus, fields, capital, capabilities and enterprise that explained 54% of the total variance explained, although the research design limited findings local scenario, suggesting the inclusion of variables that the literature identifies sociodemographic and socioeconomic variables to establish entrepreneurial profiles according to risk events; landslides, fires, droughts, floods, frosts or earthquakes
Aprovechamiento sostenible de especies vegetales para fitorremediación de vertidos en la producción porcícola del SENA CLEM TULUÁ
Authors: Pedroza Vivas Julian Andres , Tirado Diego , Polanco Manuel Federico 
Published: April 2023

The purpose of this research is to identify the plant species that allow greater decontamination of the discharges generated by the SENA-CLEM Tuluá pig farm, Valle del Cauca, becoming a pilot model that can be implemented by pig producers in Colombia, reducing the negative impacts on the environment generated by this type of livestock operations through sustainable technologies. In the research, the pollutant removal capacity of five plant species was analyzed and quantified: Lemongrass (Cymbogogon citratus), basil (Ocimum basilicum), heliconia (Heliconia rostrata), sugar cane (Saccharum officinarum) and coquito (Cyperus rotundus) , which were subjected to growth in the swine discharge treatment wetlands for 13 months; The economic benefits to producers that these plants can provide in these biosystems were also valued. To evaluate the phytoremediation action, samples of the discharges were taken at the beginning and at the end of the experiment, these were analyzed by the laboratoryWater Technology Engineeringlocated in the city of Cali-Valle del Cauca.
When performing the analysis, it was evidenced that the plants that most withstood the stress conditions were Heliconia (H.rostrata) and Sugarcane (S. officinarum) and presented removal of pollutants from chemical oxygen demand, biological demand oxygen, total suspended solids, sedimentary solids, fats and oils.
Picroside II prevents HSC activation and liver fibrosis in Mdr2-/- mice by polarizing M1 macrophages and balancing immune responses
Authors: Jia Kexin , Ma Zhi , Zhang Yinhao , Wu Jianzhi , Xue Xiaoyong , Liu Runping , Qu Jiaorong , Li Fanghong , Li Xiaojiaoyang 
Published: April 2023

Background and Purpose: Macrophages are central immune characters in
hepatic fibrosis by reconstructing the fibrotic immune microenvironment.
Picroside II (PIC II) has exerted a therapeutic potential on liver
injury. However, the mechanisms by which macrophage initiates immune
cascades and further contributes to liver fibrosis and whether this
process can be influenced by PIC II remains unclear. Experimental
Approach: In this research, the RNA sequencing of multidrug-resistance
protein 2 knockout (Mdr2-/-) mice was applied. Then aHSCs were incubated
with the medium from M1 macrophages and NK cells, with the extra
formation of neutrophils extracellular traps (NETs) being tested. In
addition, we intraperitoneal injected PIC II and then intravenously
injected the clodronate liposome to evaluate the therapeutic effect of
PIC II and macrophage deletion in Mdr2-/- mice. Key Results: We observed
the increase of CXCL16+ M1 macrophages in Mdr2-/- liver, accompanied by
the recruitment of CXCR6+ NK cells and NETs formation. PIC II promoted
the CXCL16+ macrophage recruited NK cells via CXCL16/CXCR6 axis, which
subsequently affecting the JAK1/STAT1 signaling in aHSCs. And fibrotic
liver was relieved to some extent when PIC II combined with macrophage
depletion. Conclusion and Implications: Mechanistically, PIC II
activated M1 macrophage to recruit NK cells via CXCL16-CXCR6 axis and
subsequently regulated the JAK1/STAT1 signaling to restrain aHSCs. PIC
II also alleviated fibrosis by attenuating the formation of NETs.
Notably, these PIC II-associated hepatoprotective effects were largely
reversed by macrophage depletion in Mdr2-/- mice. Collectively, our
research suggests that PIC II is potential for halting the liver
fibrosis.
Comfortable urban environment as a basis for social adaptation of people with disabilities
Authors: Khabarov V. I. , Bruev S. V. 
Published: April 2023

An urban environment with comfort zones is an important condition of modern human life, in particular, it is directly related to people who have limited mobility. The lack of necessary infrastructure makes it impossible for people with disabilities to solve everyday problems and issues.The term «accessible» or «barrier–free» environment is mentioned in many legislative acts, and has different interpretations in different sources. It should be noted that the importance of this problem has been gaining momentum in recent years, the problem of the quality and accessibility of the urban environment for people with disabilities in everyday life is beginning to come to the fore.State authorities are creating the necessary conditions for people with disabilities, which are aimed at developing services, helping to overcome barriers that prevent people with disabilities from taking full part in society. People are rethinking the quality problem anew and accessibility of the urban environment for the disabled, develop special programs to improve the quality of the urban environment.This article will help to analyze the main components of a comfortable urban environment for people with disabilities, there is a set of measures, problems, solutions that help to form a comfortable urban environment for various categories of the population.