bluuebunny/crossref_metadata_2025_split huggingface dataset:
StereoSiTE: A framework to spatially and quantitatively profile the cellular neighborhood organized iTME
Authors: Liu Xing , Qu Chi , Liu Chuandong , Zhu Na , Huang Huaqiang , Teng Fei , Huang Caili , Luo Bingying , Liu Xuanzhu , Xie Min , Xi Feng , Li Mei , Wu Liang , Li Yuxiang , Chen Ao , Xu Xun , Liao Sha , Zhang Jiajun 
Published: December 2022

AbstractWith emerging of Spatial Transcriptomics (ST) technology, a powerful algorithmic framework to quantitatively evaluate the active cell-cell interactions in the bio-function associated iTME unit will pave the ways to understand the mechanism underlying tumor biology. This study provides the StereoSiTE incorporating open source bioinformatics tools with the self-developed algorithm, SCII, to dissect a cellular neighborhood (CN) organized iTME based on cellular compositions, and to accurately infer the functional cell-cell communications with quantitatively defined interaction intensity in ST data. We applied StereoSiTE to deeply decode ST data of the xenograft models receiving immunoagonist. Results demonstrated that the neutrophils dominated CN5 might attribute to iTME remodeling after treatment. To be noted, SCII analyzed the spatially resolved interaction intensity inferring a neutrophil leading communication network which was proved to actively function by analysis of Transcriptional Factor Regulon and Protein-Protein Interaction. Altogether, StereoSiTE is a promising framework for ST data to spatially reveal tumoribiology mechanisms.
Sexism and the Far‐Right Vote: The Individual Dynamics of Gender Backlash
Authors: Anduiza Eva , Rico Guillem 
Published: December 2022

AbstractThis article contends that sexism plays a fundamental role in the electoral rise of the far right, both as a predisposition and as a changing attitude. Using panel data from Spain, we show that modern sexism is indeed among the most important attitudinal predictors of voting for the far‐right party Vox. The results also show that internal individual changes in levels of modern sexism impact far‐right voting. Backlash attitudinal change, defined as increases in sexism occurring in a context of feminist momentum, contributed significantly to the recent emergence of the radical right. Our findings indicate that sexism is not a crystalized attitude but rather susceptible to showing short‐term changes with important political consequences. This highlights the importance of understudied context‐dependent individual dynamics of gender backlash in far‐right voting.
Meta‐analysis: Use of proton pump inhibitors and risk of gastric cancer in patients requiring gastric acid suppression
Authors: Piovani Daniele , Tsantes Andreas G. , Schünemann Holger J. , Bonovas Stefanos 
Published: December 2022

SummaryBackgroundProton‐pump inhibitors (PPIs) are suspected to increase the risk of gastric cancer.AimTo assess the risk of gastric cancer associated with the use of PPIs.MethodsWe systematically searched Medline/PubMed, Embase and Scopus databases (until June 1, 2022) for randomised and non‐randomised studies (NRS) of the association between PPIs and gastric cancer having considered Histamine‐2 receptor antagonists (H2RAs) users as controls. We chose this comparison to minimise confounding by indication, and focus on patients requiring gastric acid suppression. Two authors independently extracted study data and assessed each study's risk of bias. Maximally‐adjusted relative risk (RR) estimates were extracted. Heterogeneity and small‐study effect were examined, and summary estimates were calculated using random‐ and fixed‐effect models. Stratified analyses and meta‐regression were employed to explore heterogeneity. We used GRADE to evaluate the certainty of evidence.ResultsOf 8375 records, 12 NRS (>6 million patients; 11,554 gastric cancers) and two randomised clinical trials (498 patients; 1 gastric cancer) fulfilled the eligibility criteria. Randomised evidence was very imprecise and provided very‐low certainty evidence. Meta‐analysis of six NRS providing a comprehensive adjustment for confounding (2.5 million patients; 7372 gastric cancers) did not show any association between PPIs and gastric cancer (RRrandom = 1.07, 0.97–1.19; RRfixed = 1.05, 0.98–1.12). The certainty of the evidence was low. No convincing evidence of dose–response, or increased risk with long‐term use, was found. Lack of or minimal adjustment for confounding was associated with larger effect sizes.ConclusionsWe found no association between PPIs and gastric cancer in NRS having adequately controlled for confounding. Published studies may suffer residual confounding.Systematic review registration: CRD42022335971.
A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus
Authors: Jin Chun‐xiang , Tian Jing , Yang Hui‐hui , He Yu 
Published: December 2022

AbstractBackgroundCarotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in diabetic patients with or without microvascular complications using velocity vector imaging (VVI) analysis.MethodsFifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima‐media thickness (IMT) was also measured. Flow‐mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.ResultsCCA elasticity measured by VVI decreased significantly between three groups (p < 0.05), while FMD decreased significantly only in cDM group (p < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (p < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (p < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |r | <0.8, p < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |r | <0.5, p < 0.05).ConclusionCompared with FMD, CCA elasticity measured by VVI showed more obvious changes in diabetic patients with different levels of vascular damage and may be considered as an alternative indicator in evaluating arterial status of T2DM.
Are protocol graft biopsies after pediatric liver transplantation useful? Experience in a single center over 20 years
Authors: Wischlen Emma , Boillot Olivier , Rivet Christine , Lachaux Alain , Bouvier Raymonde , Hervieu Valérie , Scoazec Jean‐Yves , Collardeau‐Frachon Sophie , Dumortier Jérôme , Laverdure Noémie 
Published: December 2022

AbstractBackgroundThe role of protocol liver biopsies (PLB) in the follow‐up of pediatric liver transplant recipients remains questionable. This single‐center retrospective study aimed to evaluate their clinical impact on the long‐term management of pediatric liver transplant recipients.MethodsWe described histopathological lesions and clinical consequences for patient management of PLB performed 1, 5, 10, 15, 20, and 25 years after pediatric liver transplantation (LT).ResultsA total of 351 PLB performed on 133 patients between 1992 and 2021 were reviewed. PLB found signs of rejection in 21.7% of cases (76/351), and moderate to severe fibrosis in 26.5% of cases (93/351). Overall, 264 PLB (75.2%) did not cause any changes to patient care. Immunosuppression was enhanced after 63 PLB, including 23 cases of occult rejection. The 1‐year PLB triggered significantly more changes, while biopsies at 15, 20, and 25 years produced the lowest rates of subsequent modifications. PLB had a significantly higher probability of inducing therapeutic changes if the patient had abnormal biological or imaging results (odds ratio [OR] 2.82 and 2.06), or a recent history of rejection or bacterial infection (OR 2.22 and 2.03).ConclusionOur results suggest that, although it often does not prompt any treatment changes, PLB could be performed because of its ability to detect silent rejection requiring an increase in immunosuppression. PLB could be carried out 1, 5, and 10 years after LT and then every 10 years in patients with normal biological and imaging results and no recent complications, while other patients could be kept on a 5‐year protocol.
Exploring the Benefits of Culturally Responsive Art Learning Experience for Rural Chinese Students
Authors: Luo Ning , Guan Tao 
Published: December 2022

AbstractThis ethnographic case study explored the benefits associated with culturally responsive art learning experience in a Chinese rural town in the process of urbanisation. The case of this study, Fuchong Art Education Programme (FAEP), provided culturally relevant art activities for primary and secondary rural students who cannot access enriched art programmes in schools. Art studio learning, a summer art camp, an art exhibition, neighbourhood sketching, online teaching, student home visits and teacher meetings were documented and examined over an eight‐month period of fieldwork. Semi‐structured interviews with the participating students, their teachers and parents and the programme coordinator were conducted to elicit the participants’ perspectives on the FAEP experience, the benefits of participation and the challenges involved in implementing a culturally responsive art programme. The emerging themes included artistic, personal, social and external benefits, which were examined in relation to previous research on the intrinsic and instrumental benefits of art learning and a local understanding of the value of community art engagement in the lives of rural people. The implications offer guidance for promoting culturally responsive art learning in rural settings.
New insights into the variability of upper airway morphology in modern humans
Authors: Maréchal Laura , Dumoncel Jean , Santos Frédéric , Astudillo Encina Williams , Evteev Andrej , Prevost Alice , Toro‐Ibacache Viviana , Venter Rudolph G. , Heuzé Yann 
Published: December 2022

AbstractThe biological adaptation of the human lineage to its environment is a recurring question in paleoanthropology. Particularly, how eco‐geographic factors (e.g., environmental temperature and humidity) have shaped upper airway morphology in hominins have been subject to continuing debate. Nasal shape is the result of many intertwined factors that include, but are not limited to, genetic drift, sexual selection, or adaptation to climate. A quantification of nasal airway (NA) morphological variation in modern human populations is crucial to better understand these multiple factors. In the present research, we study 195 in vivo CT scans of adult individuals collected in five different geographic areas (Chile, France, Cambodia, Russia, and South Africa). After segmentation of the nasal airway, we reconstruct 3D meshes that are analyzed with a landmark‐free geometric morphometrics method based on surface deformation. Our results highlight subtle but statistically significant morphological differences between our five samples. The two morphologically closest groups are France and Russia, whose NAs are longer and narrower, with an important protrusion of the supero‐anterior part. The Cambodian sample is the most morphologically distinct and clustered sample, with a mean NA that is wider and shorter. On the contrary, the Chilean sample form the most scattered cluster with the greatest intra‐population variation. The South African sample is morphologically close to the Cambodian sample, but also partially overlaps the French and Russian variation. Interestingly, we record no correlation between NA volume and geographic groups, which raises the question of climate‐related metabolic demands for oxygen consumption. The other factors of variation (sex and age) have no influence on the NA shape in our samples. However, NA volume varies significantly according both to sex and age: it is higher in males than in females and tends to increase with age. In contrast, we observe no effect of temperature or humidity on NA volume. Finally, we highlight the important influence of asymmetries related to nasal septum deviations in NA shape variation.
Canary seed, Phalaris canariensis, has higher nutritional value than giant kelp seaweed, Macrocystis pyrifera, as feed ingredient in diets for Nile tilapia, Oreochromis niloticus
Authors: Gutiérrez‐Leyva Ranferi , Rodríguez‐González Hervey , Carrillo‐Domínguez Silvia , Ulloa José A. , Ramírez‐Ramírez José C. , Rosas‐Ulloa Petra , Bautista‐Rosales Pedro U. , Civera‐Cerecedo Roberto 
Published: December 2022

AbstractNonconventional feed ingredients for different aquatic species need to be tested to establish their nutritional value. Thus, this study assessed the use of canary seed (CS), Phalaris canariensis L., and giant kelp seaweed (KS), Macrocystis pyrifera, as ingredients for Nile tilapia, Oreochromis niloticus L., feed. Two feeding trials were conducted: (1) Growth trial, where seven feeds were tested; a control diet (CD) and six CS/KS diets (100, 200, 300 g/kg). Fish fed CS/KS diets (100 and 200 g/kg) had similar weight gain to those fed CD, whereas CS/KS diets (300 g/kg) decreased growth performance (p < 0.05). The CS‐diet Economic Conversion Ratios and KS100 diet were similar to CD, while KS inclusion levels (200, 300 g/kg) decreased this parameter (p < 0.05). Dietary KS inclusion of 300 g/kg significantly decreased the profit index compared with CD and CS‐diets (p < 0.05, 2), digestibility trial, where nine feeds were evaluated: a reference diet (RD); six CS/KS diets (100, 200, 300 g/kg) to determine diet digestibility, and two CS/KS diets (300 g/kg) to determine ingredient digestibility. CS dry matter, protein, and lipid digestibility were higher than KS (p < 0.05). The results suggest that CS has higher nutritional value than KS for Nile tilapia.
Collaborations across Cinematic Objects
Authors: Browne Cynthia , Allan Diana , Kröger Merle , Scheffner Philipp , Mader Vera , Biet Marion , Frisorger Theodor , Polze Anna , Schade Julia 
Published: December 2022

AbstractThis conversation brings practitioners together from two different milieus of media production to initiate a dialogue about documentary practices as collaborative work, understood through a reflexive lens that also attends to the power relations and social differentiations inherent within its fabrication. As such, our conversation explores how filmmaking emerges through contingent and negotiated relations between filmmakers and film subjects, different representational modalities, the archive, (recording) technology and voice; the conversation also probes how the infrastructural conditions of collaborative work shape the ever‐shifting horizons of the documentary imagination. Mediated by members of the graduate research training group on Documentary Practices, based at the Ruhr University in Bochum, Germany, it features Philip Scheffner and Merle Kröger from pong, a production platform housed in Berlin, Germany, in conversation with Professor Diana Allan, a colleague of the Sensory Ethnography Lab based at Harvard University, a co‐organizer of the new Critical Media Lab at McGill University, and a Canada Research Chair in the Anthropology of Living Archives.
The Snail and Its Horns: Practical Philosophy Inspired by the Zhuangzi
Authors: Defoort Carine 
Published: December 2022

Abstract
In the last century, Western jargon and methodologies have overwhelmed the study of early Chinese texts. In an attempt to somewhat redress the balance, this paper retrieves a core notion from the Zhuangzi, “disputation” (bian 辯) or “distinctions” (bian 辨), to reflect upon a contemporary Western debate, namely about the exclusion of non-Western sources at philosophy departments. The detailed analysis of one anecdote about two states fighting each other on the horns of a snail leads to a view on disputation and its limits. By applying these insights to the “legitimacy of Chinese philosophy” debate, the Zhuangzi can inspire insights and attitudes that tend to be overlooked.
Real-world evidence of galcanezumab for migraine treatment in Japan: a retrospective analysis
Authors: Takizawa Tsubasa , Ohtani Seiya , Watanabe Narumi , Miyazaki Naoki , Ishizuchi Kei , Sekiguchi Koji , Iba Chisato , Shibata Mamoru , Takemura Ryo , Hori Satoko , Nakahara Jin 
Published: December 2022

Abstract
Objective
To evaluate the efficacy and safety of galcanezumab in patients with migraine in a real-world setting in Japan.

Background
Galcanezumab is the first anti-calcitonin gene-related peptide monoclonal antibody approved in Japan. To the best of our knowledge, no real-world studies on galcanezumab have been published in any international journal from Japan.

Methods
We retrospectively examined patients with migraine who received three doses of galcanezumab between August 2021 and February 2022 at the Keio University Hospital. We assessed changes in monthly migraine days, responder rate, and migraine-associated and premonitory symptoms. We also investigated injection site reactions and adverse events.

Results
Fifty-two patients received three doses of galcanezumab during the study period. Compared with those at baseline, the monthly migraine days decreased by 5.9 days (95% confidence interval, 4.2–7.7) at 3 months. The 50% responder rate was 61.5% at 3 months. A total of 64.9%, 50.0%, and 63.9% of patients showed improvement in the severity of photophobia, phonophobia, and nausea/vomiting, respectively. Premonitory symptoms without subsequent headache were reported in 62.5% of patients. Moreover, injection site reaction was the most common adverse event (34.6%).

Conclusion
This study revealed the efficacy and safety of galcanezumab for migraineurs in Japan. Galcanezumab also improved migraine-associated symptoms. However, despite a reduction in headaches, premonitory symptoms without subsequent headache were reported in > 50% of the patients at 3 months.
Microbial identification from traumatized immature permanent teeth with periapical lesions using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Authors: Sharaf Pervine H. , El Backly Rania M. , Sherif Raef A. , Zaazou Ashraf M. , Hafez Soad F. 
Published: December 2022

Abstract
Background
This study aims at identifying the microbiota in traumatized immature permanent teeth with periapical lesions using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).

Methods
The study included 16 immature maxillary central incisors with periapical lesions in 13 patients. Field decontamination and negative control samples were performed before and after access cavity preparation. Root canal samples were taken using sterile stainless-steel hand files following field decontamination. In-office inoculation and pure sub-cultures were performed. Bacterial isolates were prepared for MALDI-TOF MS (Bruker, Billerica, MA USA) analysis using the formic acid extraction method. A comparison of the prevalence of isolated microorganisms was done using a one-sample chi-square test. Comparisons between identified microbial species with the, cone beam computed tomography periapical index (CBCT PAI) scores and lesion volume were also conducted. The Chi-square test was applied to investigate the association between the categorical variables .

Results
Out of the forty isolates recovered from the 16 traumatized teeth included in the present study with the mean patients’ age of 10.93 ± 1.77, 37 isolates were reliably identified by MALDI-TOF MS. Twelve teeth (62.5%) were polymicrobial. The recovered bacteria belonged to five phyla, 15 genera and 25 species. Firmicutes were the predominant phylum (P < 0.001) over Bacteroidetes, Proteobacteria, Actinobacteria and Fusobacteria. Gram positive bacteria were significantly more prevalent than Gram negative (p = 0.03). Facultative anaerobes were the most prevalent (P < 0.001) compared to the obligate anaerobes and the obligate aerobes. The latter were the least prevalent. Statistically, significant differences existed in the comparison between CBCT PAI scores according to bacterial gram staining.

Conclusion
Traumatized immature permanent teeth with periapical lesions showed a significant predominance of Gram-positive facultative anaerobes. MALDI-TOF MS provided accurate identification of numerous viable endodontic microbes.
Efficacy and safety of pyronaridine-artesunate (Pyramax®) for the treatment of uncomplicated Plasmodium vivax malaria in Northwest Ethiopia
Authors: Mohammed Hussein , Sime Heven , Hailgiorgis Henok , Chernet Melkie , Alebachew Mihreteab , Solomon Hiwot , Assefa Gudissa , Haile Mebrahtom , Girma Samuel , Bekele Worku , Tasew Geremew , Gidey Bokretsion , Commons Robert J. , Assefa Ashenafi 
Published: December 2022

Abstract
Background
Declining efficacy of chloroquine for the treatment Plasmodium vivax malaria has been reported in different endemic settings in Ethiopia. This highlights the need to assess alternative options for P. vivax treatment with artemisinin-based combination therapy, such as pyronaridine-artesunate. This treatment regimen has shown high efficacy for uncomplicated malaria in both Africa and Asia. However, limited data are available from Ethiopia. This study was conducted to assess the efficacy and safety of pyronaridine-artesunate for the treatment of uncomplicated P. vivax malaria in Northwest Ethiopia.

Methods
A single arm prospective efficacy study was conducted in the Hamusite area, Northwest Ethiopia. Fifty-one febrile adult patients with uncomplicated P. vivax malaria were enrolled between March and July 2021. Patients were treated with pyronaridine-artesunate once daily for three days. Clinical and parasitological parameters were monitored over a 42-day follow-up period using the standard World Health Organization protocol for therapeutic efficacy studies.

Results
A total of 4372 febrile patients were screened with 51 patients enrolled and 49 completing the 42-day follow-up period. The PCR-uncorrected adequate clinical and parasitological response (ACPR) was 95.9% (47/49; 95% CI 84.9–99.0) on day 42. Two patients had recurrences [4.0% (2/49); 95% CI 0.7–12.1] on days 35 and 42. The parasite clearance rate was rapid with fast resolution of clinical symptoms; 100% of participants had cleared parasitaemia on day 1 and fever on day 2. All 16 (31.4%) patients with gametocyte carriage on day 0 had cleared by day 1. There were no serious adverse events.

Conclusion
In this small study, pyronaridine-artesunate was efficacious and well-tolerated for the treatment of uncomplicated P. vivax malaria. In adults in the study setting, it would be a suitable alternative option for case management.