bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressive pseudo-rheumatoid dysplasia -a rare genetic disorder: Case Report
Authors: Chowdhury Md Faizul Islam , Shova Shamima Sharmin , Monami Afia Zahin , Alam Rajibul , Rahman M Ekhlasur 
Published: March 2023

Progressive pseudorheumatoid dysplasia (PPRD), also known as spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA), is an autosomal recessive disorder, resulting from mutations in the WNT1-inducible signaling pathway protein 3 (WISP3) gene involving the axial skeleton as well as small peripheral joints. Because of rarity here we present a case of 14-year-old boy, 1st issue of consanguineous parents who was presented with pain & gradual development of contracture in 3rd distal interphalangeal joint of right hand when he was 4-year-old, then gradual involvement of other interphalangeal joints of hands, bilateral wrists, elbows, shoulder, knees &ankles occurred over years with the development of contractures and restricted movement. For last few years, he developed difficulty in walking. Clinically spinal scoliosis and coxa vara was present. Mobility of spines and multiple joints including proximal & distal interphalangeal joints of hands, wrists, elbows, shoulders, knees, ankles were restricted with flexion contractures. The gait of the patient was limping. Radiological evaluation showed osteopenia in X-ray of pelvis with both hip joints and both knee joints. Generalized osteopenia, fusiform swelling in distal interphalangeal joint, flexion deformity in distal interphalangeal joint of middle and ring fingers of both hand was shown in X-ray of both hands. MRI of lumbosacral spine showed dorso-lumbar vertebral bodies dysplastic with anterior wedging producing bullet nose. Superior epiphyseal deformity was also noted in lower dorsal bodies suggestive of spondyloepiphyseal dysplasia of dorso-lumbar spine. Genetic study showed homozygous nonsense variation in exon 5 of the WISP3 gene suggestive pathogenic variant. Finally, he was diagnosed as a case of PPRD and treated with physiotherapy, family counseling, and anti-inflammatory medications.
AKMMC J 2022; 13(1) : 52-55
Primary Distal renal tubular acidosis: case series
Authors: Halder Soma , Ferdous Jannatul , Tajkia Gule , Roy Kuntal , Amin Syed Khairul , Rahman M Ekhlasur , Hanif Mohammad 
Published: March 2023

Primary Distal renal tubular acidosis is an infrequent tubular disorder with complex pathophysiology that present with poor growth, skeletal changes and sometimes life-threatening hypokalemia. Here we present two siblings one girl and one boy with a consanguineous parents presented with polyuria, polydipsia, failure to thrive and skeletal deformity. Both cases showed non-anion gap metabolic acidosis with alkaline urine and the younger brother had periodic paralysis due to hypokalemia. After diagnosis and treatment they showed good response with alkali therapy.
AKMMC J 2022; 13(1) : 56-59
Effects of Integrated Nutrient Management Uptake On Seed Yield of Onion
Authors: Yousuf MN , Brahma S , Khan MAA , Sarker MMA , Datta SK 
Published: March 2023

The field experiment was conducted during two successive rabi seasons of 2015-16 and 2016-17 in the research field of BARI, Gazipur, to evalute the effect of integrated nutrient management (INM) on seed yield and nutrient uptake of onion (var. BARI Piaz-1). The experiment was arranged in Randomized Complete Block Design (RCBD) with three replications having eight nutrient management packages following the INM principle. There were significant effects of INM on the seed yield, yield contributing characters and nutrient uptake of onion. The highest seed yield of 1278 and 1287 kg ha-1 was obtained from treatment poultry liter (PL) based trichocompost (TC) @ 3t ha-1 + chemical fertilizers (IPNS basis) and the minimum seed yield (395 kg ha-1 and 441 kg ha-1) in control (native fertility) treatment in 2015-2016 and 2016-2017, respectively. The N uptake by onion crop ranged from 37.1 to 141.5 kg ha-1 and 42.1 to 146.7 kg ha-1, P uptake from 2.9 to 13.5 kg ha-1 and 3.8 to 20.2 kg ha-1, K uptake from 24.5 to 76.7 kg ha-1 and 30.7 to 74.3 kg ha-1 and the S uptake ranged from 5.8 to 14.5 kg ha-1 and 6.1 to 18.8 kg ha-1 in two respective years. Hence, the PL based TC @ 3 t ha-1 + CF (IPNS) could be regarded as the best nutrient management package for achieving higher onion seed production in Grey Terrace Soil of Madhupur Tract (AEZ-28).
Bangladesh J. Agril. Res. 46(4): 417-424, December 2021
Assessment of Inbred Lines of Field Corn for Yield And Yield Attributes Through Line × Tester Method
Authors: Karim ANMS , Talukder ZA , Omy SH , Sultana R , Alam MK 
Published: March 2023

A line × tester analysis comprising forty eight test-crosses generated by crossing 24 S3 inbred lines derived from commercial maize hybrid 981 with two testers. Heterosis study of these crosses against two standard checks was evaluated at Bangladesh Agricultural Research Institute, Gazipur during rabi 2015-16. The objectives of the study were to estimate general and specific combining ability effects of the inbred lines and to assess the test cross performance and estimate the amount of standard-heterosis of the hybrids for grain yield and yield related characters. Highly significant genotypic differences were observed indicated wide range of variability present among them. Five lines viz. Line 11, Line 14, Line 17, Line 24 and Line 30 were good general combiner for grain yield and possessed high means. Nine crosses showed (Line 18 × BIL22, Line 23 × BIL22, Line 27 × BIL22, Line 7 × BIL28, Line11 × BIL28, Line14 × BIL28, Line 24 × BIL28, Line 25 × BIL28 and Line 30 × BIL28) significant and positive specific combining ability effect for grain yield. The information on the nature of gene action with respective variety and characters might be used depending on the breeding objectives. These crosses, Line 24× BIL28 (11.40 t/ha), Line 18 × BIL22 (11.30 t/ha) and Line 25 × BIL28 (11.20 t/ha) showed higher yield, could be utilized in maize breeding activities. Estimation of heterosis was carried out using two commercial hybrids BARI Hybrid Maize-9 (BHM-9) and NK-40. The percent heterosis for grain yield varied from -23.39 to 4.6% against BHM-9. Among the 48 crosses, 13 crosses exhibited significant positive heterosis for grain yield.
Bangladesh J. Agril. Res. 46(4): 469-489, December 2021
MERAWAT NILAI TRADISI KE-NU-AN PADA SISWA MELALUI MATA PELAJARAN ASWAJA
Authors: Muliatama Elfa 
Published: March 2023

This study aims to determine how the existence of Aswaja subjects in preserving the traditional values ​​of the NU's in MAN Tambakberas Jombang. The existence of aswaja subjects referred to here is the existence of aswaja subjects which are carried out consciously, directed and continuously to introduce and instill Aswaja and NU's religious understanding to students, so that they know, believe and practice them in the sense of making them a life guide. personal, social, national and state. This research is a qualitative research. The subjects of this study were the Aswaja teachers and the students of MAN Tambakberas Jombang. The object of this research is Aswaja and NU's education which is carried out through guidance, teaching, training, and learning experiences. Data collection techniques in this study are observation, interviews, and documentation. The data analysis used in this research is descriptive qualitative data analysis.
Keywords: Existence of Aswaja subjects, Preserving the values ​​of the NU's tradition

Abstrak
Penelitian ini bertujuan untuk mengetahui bagaimana eksistensi mata pelajaran aswaja dalam melestarikan nilai-nilai tradisi ke-NU-an di MAN Tambakberas Jombang. Eksistensi mata pelajaran aswaja yang dimaksud disini adalah adanya mata pelajaran aswaja yang dilakukan secara sadar, terarah dan berkesinambungan untuk memperkenalkan dan menanamkan paham keagamaan Aswaja dan Ke-NU-an kepada peserta didik, agar mereka mengetahui, meyakini dan mengamalkannya dalam pengertian menjadikannya sebagai pedoman kehidupan pribadi, bermasyarakat, berbangsa dan bernegara. Penelitian ini merupakan penelitian kualitatif. Subjek penelitian ini adalah guru Aswaja dan para siswa MAN Tambakberas Jombang. Objek penelitian ini adalah pendidikan Aswaja dan ke-NU-an dilakukan melalui kegiatan bimbingan, pengajaran, latihan, serta pengalaman belajar. Teknik pengumpulan data pada penelitian ini yaitu observasi, wawancara, dan dokumentasi. Analisis data yg digunakan dalam penelitian ini yaitu analisis data deskriptif kualitatif.
Kata kunci : Eksistensi, mata pelajaran aswaja, nilai-nilai tradisi ke-NU-an
ORIENTASI MORAL DENGAN PENDEKATAN KEAGAMAAN DALAM SUPERVISI PENDIDIKAN AGAMA ISLAM
Authors: Adabi Husni 
Published: March 2023

The objectives of this study are, 1) To explain educational supervision in moral orientation by educators using a religious approach. 2) Explain the importance of moral orientation that must be done by educators to students. 3) To find out the efforts made by educators in increasing the ability and implementation of moral orientation with a religious approach. 4) To find out about the weaknesses of Islamic religious education in Indonesia today so that educators can better anticipate and improve this. 5) To know a comprehensive approach to learning Islamic religious education.
Keywords: Moral Orientation, Religious, Supervision, Teacher, Islamic education.

Abstrak
Tujuan dalam penelitian ini adalah, 1) Menjelaskan mengenai supervisi pendidikan dalam orientasi moral yang dilakukan pendidik dengan menggunakan pendekatan keagamaan. 2) Menjelaskan pentingnya orientasi moral yang harus dilakukan pendidik kepada peserta didik. 3) Untuk mengetahui upaya-upaya yang dilakukan pendidik dalam meningkatkan kemampuan dan pelaksanaan orientasi moral dengan pendekatan keagamaan. 4) Untuk mengetahui tentang kelemahan pendidikan agama Islam di Indonesia sekarang ini agar pendidik lebih dapat mensiasati dan memperbaiki hal tersebut. 5) Untuk mengetahui pendekatan pembelajaran pendidikan agama Islam secara komprehensif.
KataKunci: Orientasi Moral, Keagamaan, Supervisi, Guru, Pendidikan Agama Islam.
Efektifitas Cadre Refreshment dalam peningkatan peran kader dalam penanggulangan TBC di Kabupaten Sumenep
Authors: Trisno Zetiawan , Nurhakim Lukman 
Published: March 2023

Tuberculosis is a deadly infectious disease caused by the bacterium Mycobacterium tuberculosis. Indonesia is currently in the second-highest position in the world. Efforts to break the chain of TB in the community require capacity building for cadres as the spearhead in finding and assisting people with TB. The involvement of cadres in TB control programs can be realized through the provision of training. The purpose of cadre refreshment training is to provide understanding and skills for cadres in carrying out case-finding activities and treatment assistance for TB patients. The method used in this activity consists of teaching, simulation, field practice, and continuous evaluation. This training was attended by 45 cadres from 18 areas of the YABHYSA SSR intervention health center Sumenep. Cadre participants consist of 85% women and 15% men and most of them are at the productive age of 89%.
Edukasi Optimalisasi Pelaksanaan Pemberian Makanan Tambahan (PMT) di Kelurahan Sei Keledang
Authors: Astani Ameliora Dwi , Sundu Reksi , Fatimah Nurul 
Published: March 2023

Abstract : Malnutrition in East Borneo has been in the chronic-acute category. As the capital city of East Borneo, Samarinda has a high prevalence of stunted dan wasted children. Therefore, the government set up a program called Pro-Bebaya. This program supports the health ministry program to reduce malnutrition among children through a supplementary food program (PMT). In Sei Keledang district (part of Samarinda) there are several problems regarding the PMT program, like inadequate infrastructure, decrement of posyandu visits, and limitation in monitoring nutrition status.
Abstrak : Permasalahan gizi di wilayah Kalimantan Timur masuk ke dalam wilayah gizi kronis-akut. Ibukota Kaltim, Kota Samarinda memiliki prevalensi balita pendek dan kurus yang cukup tinggi. Oleh karena itu, dilakukan upaya pengentasan malnutrisi melalui program Pro-Bebaya. Program ini mendukung salah satu program kesehatan, yaitu penyelenggaraan PMT (Pemberian Makanan Tambahan) yang ditujukan pada anak dan balita. Namun, di wilayah Sei Keledang timbul beberapa kendala, antara lain sarana dan prasana yang tidak memadai, penurunan kunjungan posyandu, dan keterbatasan dalam monitoring status gizi.
UJI AKTIVITAS ANTIBAKTERI NANOPARTIKEL EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R. Forst & G. Forst) TERHADAP BAKTERI Streptococcus mutans
Authors: Fahira Nelsa , Rahayu Yayuk Putri , Nasution Haris Munandar , Nasution M Pandapotan 
Published: March 2023

Streptococcus mutans is one of the bacteria that plays an important role in the formation of dental caries. One of the plants known to have antibacterial compounds are matoa leaves (Pometia pinnata J.R. Forst & G. Forst) family Sapindaceae. The objective of this research was to determine the antibacterial activity of matoa leaves ethanolic extract nanoparticles is better than matoa leaves ethanolic extract against S. mutans bacteria. The research method was carried out experimentally. Free variables, namely the concentration of matoa leaf ethanol extract (KEDM 25% ; KEDM 50%; and KEDM 75%) and the concentration of nanoparticles of matoa leaf ethanol extract (KNDM 2.5%; KNDM 5%; and KNDM 7.5%). Bound variables are antibacterial activity of ethanol extract and nanoparticles of matoa leaf ethanol extract against S. mutans bacteria. The nanoparticle size of the extract was characterized using a Particle Size Analyzer (PSA). Test of antibacterial activity of ethanol extract and matoa leaf ethanol extract nanoparticles against S. mutans using the diffusion method to Kirby Bauer. The result of the extract nanoparticle size characterization was 324.97 nm. Zone of Inhibition (ZOI) values of antibacterial ethanol extract of matoa leaves against S. mutans were 12.00 mm (KEDM 25%), 12.50 mm (KEDM 50%), and 12.60 mm (KEDM 75%). The antibacterial ZOI values of matoa leaf ethanol extract nanoparticles against S. mutans were 8.00 mm (KNDM 2.5%), 9.06 mm (KNDM 5%), and 10.10 mm (KNDM 7.5%). The conclusion is that ethanol extract of matoa leaves can be used as extract nanoparticles, where the extract nanoparticle concentration of 7.5% already has the ability of antibacterial activity that is close to the concentration of 25% ethanol extract, so that it can be said that the extract nanoparticle preparation can reduce the dose of a drug even though it is in the resistant category compared to Amoxicillin 25 g with the susceptible category.
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
Authors: Calvo-Gallego José Luis , Manchado-Morales Pablo , Pivonka Peter , Martínez-Reina Javier 
Published: March 2023

Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, the differentiation into mature resorbing osteoclasts and mature forming osteoblasts from their respective precursor cells was modelled as an intermittent process based on precursor cells availability. Second, the interaction between neighbouring BMUs was considered based on a “metabolic cost” argument which warrants that no new BMU will be activated in the neighbourhood of an existing BMU. With the proposed model we have simulated the phases of the remodelling process obtaining average periods similar to those found in the literature: resorption (∼22 days)—reversal (∼8 days)—formation (∼65 days)—quiescence (560–600 days) and an average BMU activation frequency of ∼1.6 BMUs/year/mm3. We further show here that the resorption and formation phases of the BMU become coordinated only by the presence of TGF-β (transforming growth factor β), i.e., a major coupling factor stored in the bone matrix. TGF-β is released through resorption so upregulating osteoclast apoptosis and accumulation of osteoblast precursors, i.e., facilitating the transition from the resorption to the formation phase at a given remodelling site. Finally, we demonstrate that this model can explain targeted bone remodelling as the BMUs are steered towards damaged bone areas in order to commence bone matrix repair.
Biomechanical comparison of anterior axis-atlanto-occipital transarticular fixation and anterior atlantoaxial transarticular fixation after odontoidectomy: A finite element analysis
Authors: Lu Yuzhao , Hang Gai , Feng Yu , Chen Bo , Ma Shenghui , Wang Yang , Xie Tianhao 
Published: March 2023

Background: Anterior axis-atlanto-occipital transarticular fixation (AAOF) and anterior atlanto-axial transarticular fixation (AAF) are two common anterior screw fixation techniques after odontoidectomy, but the biomechanical discrepancies between them remain unknown.Objectives: To investigate the biomechanical properties of craniovertebral junction (CVJ) after odontoidectomy, with AAOF or AAF.Methods: A validated finite element model of the intact occipital-cervical spine (from occiput to T1) was modified to investigate biomechanical changes, resulting from odontoidectomy, odontoidectomy with AAOF, and odontoidectomy with AAF.Results: After odontoidectomy, the range of motion (ROM) at C1-C2 increased in all loading directions, and the ROM at the Occiput-C1 elevated by 66.2%, 57.5%, and 41.7% in extension, lateral bending, and torsion, respectively. For fixation models, the ROM at the C1-C2 junction was observably reduced after odontoidectomy with AAOF and odontoidectomy with AAF. In addition, at the Occiput-C1, the ROM of odontoidectomy with AAOF model was notably lower than the normal model in extension (94.9%), flexion (97.6%), lateral bending (91.8%), and torsion (96.4%). But compared with the normal model, in the odontoidectomy with AAF model, the ROM of the Occiput-C1 increased by 52.2%, −0.1%, 92.1%, and 34.2% in extension, lateral bending, and torsion, respectively. Moreover, there were no distinctive differences in the stress at the screw-bone interface or the C2-C3 intervertebral disc between the two fixation systems.Conclusion: AAOF can maintain CVJ stability at the Occiput-C1 after odontoidectomy, but AAF cannot. Thus, for patients with pre-existing atlanto-occipital joint instability, AAOF is more suitable than AAF in the choice of anterior fixation techniques.
Effect of the uronic acid composition of alginate in alginate/collagen hybrid hydrogel on chondrocyte behavior
Authors: Zheng Guoshuang , Xue Chundong , Cao Fang , Hu Minghui , Li Maoyuan , Xie Hui , Yu Weiting , Zhao Dewei 
Published: March 2023

Introduction: Developing a culture system that can effectively maintain chondrocyte phenotype and functionalization is a promising strategy for cartilage repair.Methods: An alginate/collagen (ALG/COL) hybrid hydrogel using different guluronate/mannuronate acid ratio (G/M ratio) of alginates (a G/M ratio of 64/36 and a G/M ratio of 34/66) with collagen was developed. The effects of G/M ratios on the properties of hydrogels and their effects on the chondrocytes behaviors were evaluated.Results: The results showed that the mechanical stiffness of the hydrogel was significantly affected by the G/M ratios of alginate. Chondrocytes cultured on Mid-G/M hydrogels exhibited better viability and phenotype preservation. Moreover, RT-qPCR analysis showed that the expression of cartilage-specific genes, including SOX9, COL2, and aggrecan was increased while the expression of RAC and ROCK1 was decreased in chondrocytes cultured on Mid-G/M hydrogels.Conclusion: These findings demonstrated that Mid-G/M hydrogels provided suitable matrix conditions for cultivating chondrocytes and may be useful in cartilage tissue engineering. More importantly, the results indicated the importance of taking alginate G/M ratios into account when designing alginate-based composite materials for cartilage tissue engineering.
Perioperative parameters-based prediction model for acute kidney injury in Chinese population following valvular surgery
Authors: Yan Yun , Gong Hairong , Hu Jie , Wu Di , Zheng Ziyu , Wang Lini , Lei Chong 
Published: March 2023

BackgroundAcute kidney injury (AKI) is a relevant complication after cardiac surgery and is associated with significant morbidity and mortality. Existing risk prediction tools have certain limitations and perform poorly in the Chinese population. We aimed to develop prediction models for AKI after valvular cardiac surgery in the Chinese population.MethodsModels were developed from a retrospective cohort of patients undergoing valve surgery from December 2013 to November 2018. Three models were developed to predict all-stage, or moderate to severe AKI, as diagnosed according to Kidney Disease: Improving Global Outcomes (KDIGO) based on patient characteristics and perioperative variables. Models were developed based on lasso logistics regression (LLR), random forest (RF), and extreme gradient boosting (XGboost). The accuracy was compared among three models and against the previously published reference AKICS score.ResultsA total of 3,392 patients (mean [SD] age, 50.1 [11.3] years; 1787 [52.7%] male) were identified during the study period. The development of AKI was recorded in 50.5% of patients undergoing valve surgery. In the internal validation testing set, the LLR model marginally improved discrimination (C statistic, 0.7; 95% CI, 0.66–0.73) compared with two machine learning models, RF (C statistic, 0.69; 95% CI, 0.65–0.72) and XGBoost (C statistic, 0.66; 95% CI, 0.63–0.70). A better calibration was also found in the LLR, with a greater net benefit, especially for the higher probabilities as indicated in the decision curve analysis. All three newly developed models outperformed the reference AKICS score.ConclusionAmong the Chinese population undergoing CPB-assisted valvular cardiac surgery, prediction models based on perioperative variables were developed. The LLR model demonstrated the best predictive performance was selected for predicting all-stage AKI after surgery.Clinical trial registrationTrial registration: Clinicaltrials.gov, NCT04237636.