bluuebunny/crossref_metadata_2025_split huggingface dataset:
RotaRod and acoustic startle reflex performance of two potential mouse models for Meniere's disease
Authors: Babu Vidya , Bahari Rose , Laban Nora , Kulaga Jacob , Abdul Zahid , Zakkar Basil , Al‐Najjar Ahmad , Lesus Joseph , Al‐Rifai Abd‐al‐Rahman , Sattar Heba , Irukulla Suhitha , Gunniya Pranav , Requena Teresa , Lysakowski Anna 
Published: July 2023

AbstractMeniere's disease (MD) is a disorder of the inner ear characterized by chronic episodes of vertigo, tinnitus, increased aural pressure, and sensorineural hearing loss. Causes of MD are unknown, but endolymphatic hydrops is a hallmark. In addition, 5%–15% of MD cases have been identified as familial. Whole‐genome sequencing studies of individuals with familial MD identified DTNA and FAM136A as candidate genes for autosomal dominant inheritance of MD. Although the exact roles of these genes in MD are unknown, FAM136A encodes a mitochondrial protein, and DTNA encodes a cytoskeletal protein involved in synapse formation and maintenance, important for maintaining the blood–brain barrier. It is also associated with a particular aquaporin. We tested vestibular and auditory function in dtna and fam136a knockout (KO) mice, using RotaRod and startle reflex‐based clicker tests, respectively. Three‐factor analysis of variance (ANOVA) results indicated that sex, age, and genotype were significantly correlated with reduced mean latencies to fall (“latencies”) for male dtna KO mice, while only age was a significant factor for fam136a KO mice. Fam136a KO mice lost their hearing months before WTs (9–11 months vs. 15–20 months). In male dtna KO mice, divergence in mean latencies compared with other genotypes was first evident at 4 months of age, with older males having an even greater decrease. Our results indicate that fam136a gene mutations generate hearing problems, while dtna gene mutations produce balance deficits. Both mouse models should help to elucidate hearing loss and balance‐related symptoms associated with MD.
A review on isothermal rotating bending fatigue failure: Microstructural and lifetime modeling of wrought and additive manufactured alloys
Authors: Behvar Alireza , Berto Fillipo , Haghshenas Meysam 
Published: July 2023

AbstractThe cumulative effect of many incidents that are brought about by an increase in temperature establishes an environment in which premature failure (including fatigue failure) becomes a challenging issue. Isothermal rotating bending fatigue (IT‐RBF) testing may simulate industrial components' high temperatures and rotating environments. This state‐of‐the‐art review paper covers the current research on IT‐RBF failure in wrought and additive‐manufactured alloys, focusing on microstructural and lifetime models. The article emphasizes the need of using microstructural information in fatigue life models to better represent complex material structure‐failure behavior associations. Additive‐manufactured alloys contain unique microstructural characteristics and processing‐induced defects making fatigue modeling difficult. The paper concludes with implications for industrial fatigue‐resistant alloy development. It emphasizes the necessity for a multidisciplinary approach that integrates materials science, mechanics, and data science to optimize these materials under cyclic loads. The review concludes by proposing future research and innovation in this subject.
Patterns of ethanol intake in male rats with partial dopamine transporter deficiency
Authors: Kuiper L. B. , Roberts J. B. , Estave P. M. , Leo D. , Gainetdinov R. R. , Jones S. R. 
Published: July 2023

AbstractMesolimbic dopamine signaling plays a major role in alcohol and substance use disorders as well as comorbidities such as anxiety and depression. Growing evidence suggests that alcohol drinking is modulated by the function of the dopamine transporter (DAT), which tightly regulates extracellular dopamine concentrations. Adult male rats on a Wistar Han background (DAT+/+) and rats with a partial DAT deletion (DAT+/−) were used in this study. First, using fast‐scan cyclic voltammetry in brain slices containing the nucleus accumbens core from ethanol‐naïve subjects, we measured greater evoked dopamine concentrations and slower dopamine reuptake in DAT+/− rats, consistent with increased dopamine signaling. Next, we measured ethanol drinking using the intermittent access two‐bottle choice paradigm (20% v/v ethanol vs. water) across 5 weeks. DAT+/− rats voluntarily consumed less ethanol during its initial availability (the first 30 min), especially after longer periods of deprivation. In addition, DAT+/− males consumed less ethanol that was adulterated with the bitter tastant quinine. These findings suggest that partial DAT blockade and concomitant increase in brain dopamine levels has potential to reduce drinking and ameliorate alcohol use disorder (AUD).
A generalized framework to expand incomplete phylogenies using non‐molecular phylogenetic information
Authors: Ramos‐Gutiérrez Ignacio , Lima Herlander , Vilela Bruno , Molina‐Venegas Rafael 
Published: July 2023

AbstractAimThe increasing availability of molecular information has lifted our understanding of species evolutionary relationships to unprecedent levels. However, current estimates of the world's biodiversity suggest that about a fifth of all extant species are yet to be described, and we still lack molecular information for many of the known species. Hence, evolutionary biologists will have to tackle phylogenetic uncertainty for a long time to come. This prospect has urged the development of software to expand phylogenies based on non‐molecular phylogenetic information, and while the available tools provide some valuable features, major drawbacks persist and some of the proposed solutions are hardly generalizable to any group of organisms.InnovationHere, we present a completely generalized and flexible framework to expand incomplete phylogenies. The framework is implemented in the R package “randtip”, a toolkit of functions that was designed to randomly bind phylogenetically uncertain taxa in backbone phylogenies through a fully customizable and automatic procedure that uses taxonomic ranks as a major source of phylogenetic information. Although randtip can generate fully operative phylogenies for any group of organisms using just a list of species and a backbone tree, we stress that the “blind” expansion of phylogenies using “quick‐and‐dirty” approaches often leads to suboptimal solutions. Thus, we discuss a variety of circumstances that may require customizing simulation parameters beyond default settings to optimally expand the trees, including a detailed step‐by‐step tutorial that was designed to provide guidelines to non‐specialist users.Main ConclusionsPhylogenetic uncertainty should be tackled with caution, assessing potential pitfalls and opportunities to optimize parameter space prior to launch any simulation. Used judiciously, our framework will help evolutionary biologists to efficiently expand incomplete phylogenies and thereby account for phylogenetic uncertainty in quantitative analyses.
(Bi0.5Na0.5)(Zr0.97W0.01Fe0.02)O3 doping effects on KNN‐based lead‐free ceramics prepared via two‐step sintering technique
Authors: Li Wanji , Fang Bijun , Lu Xiaolong , Zhang Shuai , Ding Jianning 
Published: July 2023

Abstract(1‐x)(Li0.02Na0.5K0.48)(Nb0.95Sb0.05)O3‐x(Bi0.5Na0.5)(Zr0.97W0.01Fe0.02)O3 (LNKNbS‐xBiNZWF, x = 0.035, 0.04, 0.045, 0.05, and 0.055) lead‐free piezoceramics were fabricated by traditional solid‐state sintering method via two‐step sintering technique, where the effects of BiNZWF doping amount and ceramic processing were studied systematically. The formation of orthorhombic‐tetragonal (O‐T) phase boundary in the LNKNbS‐xBiNZWF system is confirmed by X‐ray diffraction Rietveld refinement and Raman spectroscopy, where the BiNZWF doping amount affects the O‐T phase proportion. The LNKNbS‐xBiNZWF ceramics approach to normal ferroelectrics but have apparent relaxation characteristic. Oxygen vacancies dominate the high‐temperature conduction in the LNKNbS‐0.04BiNZWF ceramics, which are generated by the volatilization of Bi and alkali metals during sintering. The LNKNbS‐0.04BiNZWF ceramics exhibit excellent electrical properties, correlating with using the two‐step sintering method, appropriate proportion of O phase and T phase, high densification and improved microstructure uniformity.
Colonic cytomegalovirus DNA detection by polymerase chain reaction does not influence outcomes in inflammatory bowel disease and immunosuppressed cohorts
Authors: Nguyen Paul , Shrestha Atul , Sane Nikhita , Abeywickrama Dilini , Holt Darcy Q. , Bell Sally , Moore Gregory , Goldberg Rimma 
Published: July 2023

AbstractBackground and AimCytomegalovirus (CMV) colitis is associated with negative outcomes in inflammatory bowel disease (IBD) and immunosuppressed cohorts and therefore requires timely recognition for appropriate management. We aimed to evaluate the diagnostic tools for CMV colitis and their associations with clinical outcomes.MethodsA retrospective cohort study of patients in a metropolitan health service with colonic samples analysed for CMV between 2012 and 2022, stratified into IBD and non‐IBD groups, was performed. The main outcome measures were the prevalence of positive and negative results for each CMV test, as well as need for colectomy, use of antiviral and hospital length of stay.ResultsFive hundred eighty‐two biopsies from 418 patients were included; the median age was 36 years (interquartile range, 24–52 years) and 223 (53.3%) were men. Four hundred sixty‐one (79.2%) biopsies were from patients with IBD and 121 (20.8%) were from those without IBD. There were similar proportions of positive CMV histology (IBD 5.9% and non‐IBD 7.4%) and tissue CMV polymerase chain reaction (PCR) in the two groups (IBD 5.6% and non‐IBD 5.0%), but within each group, results were discordant. Positive CMV histology was significantly associated with need for colectomy in the IBD group, while positive tissue CMV PCR was not. Positive CMV histology, and tissue and serum CMV PCR were all significantly associated with antiviral use. Positive serum CMV PCR was significantly associated with colectomy.ConclusionsHistopathology remains the most predictive tool in assessing CMV colitis, while qualitative tissue CMV PCR was found to have limited utility. Quantitative serum CMV PCR may be useful but requires further evaluation.
Predictors of severe and recurrent adult anaphylaxis, and gaps in the cascade of care: a retrospective, single‐centre study 2009–2018
Authors: Loprete Jacqueline , Montemayor Jonathan , Bramah Valerie , McEwan Callum , Richardson Robyn , Green Jessica , Carr Andrew , Tong Winnie 
Published: July 2023

AbstractBackgroundAnaphylaxis is a severe, potentially fatal, systemic allergic reaction. Understanding predictors of recurrent and severe anaphylaxis in adults, and identifying gaps in ongoing anaphylaxis care, is needed to minimise its impact.AimsTo evaluate the risk factors in adults with severe and recurrent anaphylaxis presentations and to evaluate the management of patients in regard to the recommended cascade of care.MethodsWe completed a retrospective audit of adults with confirmed anaphylaxis who presented to an inner‐city emergency department from 1 January 2009 through 31 December 2018. Data recorded included demographics, background history, medication use, severity, co‐factors, triggers, management, discharge disposition and referral for follow‐up. Data were managed in REDCap and analysed using Stata. Associations were assessed through odds ratios (ORs) and t tests.ResultsSix hundred sixteen individuals had 689 episodes of anaphylaxis over the audit period. Age over 65 (OR: 5.4 (95% confidence interval, CI: 2.3–13.2), P < 0.0001) and history of asthma (OR: 1.6 (95% CI: 1.03–2.5), P = 0.03) were independent risk factors for severe anaphylaxis. History of food allergy (P < 0.001) and food as the trigger were associated with recurrent presentations (OR: 2.1, 95% CI: 1.1–3.9, P = 0.01). Only 19% of patients met the recommended cascade of care, with post‐adrenaline monitoring and recommending follow‐up with an allergy specialist demonstrating the largest gaps. There were increased presentations with time but no difference in triggers or severity.ConclusionsIncreased age and asthma were identified as risk factors for severe presentations. History of food allergy was a risk factor for recurrent presentations. Further research is needed on the gaps in care for adults with anaphylaxis to identify the reasons why, so we can better care for these patients.
Factors influencing the transition of foreign‐educated nurses to the US healthcare setting: A systematic review
Authors: Thomas Joicy B. , Lee Mikyoung A. 
Published: July 2023

AbstractAimThis literature review examined the impact of the orientation or onboarding programs on the transition of foreign‐educated nurses to a US healthcare setting and factors influencing their transition.BackgroundRecruitment of foreign‐educated nurses has been a solution to the ongoing nursing workforce shortage in the United States. However, they face various challenges in their transition to employment in the United States. Adequate orientation and continued support are needed for the successful transition of foreign‐educated nurses.MethodsA systematic literature search was conducted in 2022 across PubMed, CINAHL, Academic Search Complete, Google Scholar, and MEDLINE databases. This review selected only articles published between 2015 and 2022 in English that addressed foreign‐educated nurses’ transition issues in US healthcare settings. The review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The quality of the articles was appraised using the John Hopkins Evidence‐based Practice tool.ResultsThis review of 14 articles revealed that the quality of orientation and organizational support were positively associated with foreign‐educated nurses’ job satisfaction and turnover. Factors influencing foreign‐educated nurses’ transition included peer support, job assignment and workload, credentialing, communication and cultural adjustment, psychological factors, safety perceptions, work environment, and coping strategies.DiscussionThere was a lack of literature that evaluated orientation or onboarding programs for foreign‐educated nurses. Further research is needed to explore the effectiveness of supportive programs in promoting their smooth transition.Implications for nursing practice and policyEfficient onboarding or orientation programs and policies for foreign‐educated nurses are crucial, considering the factors influencing their transition. Good programs and policies that prioritize the support, integration, and professional development of FENs will help maximize their contributions to health care.
Inorganic remote glass film based on yellowish‐green (Y, Ba)3(Al, Si)5O12:Ce garnet phosphor for warm white LEDs
Authors: Zhang Yuting , Tu Huan , Zhao Guoying , Hou Jingshan , Liu Yufeng , Qiao Xin , Wang Zhongzhi , Li Bo , Li Ji‐Guang , Wang Feng , Fang Yongzheng 
Published: July 2023

AbstractCompared with other fluorescent crystal phases, garnet has better structural stability in a glass matrix and renders precisely controllable emissions due to the abundant lattice control positions. In this work, we regulate the coordination field of Ce3+ ion based on the co‐substitution method and achieve the spectra regulation in the yellow–green range. We used Ba2+–Si4+ cations to replace Y3+–Al3+ cations in Y3Al5O12 (YAG) matrix to obtain blue‐shift of the emission peak from 552 to 539 nm. The centroid shift and crystal field splitting decrease with the decreasing covalency of the bond between the Ce3+ ion and the surrounding anions owing to the higher electronegativity of Si4+ ions than Al3+ ions. The corresponding fluorescent films were prepared by a low‐temperature co‐sintering process based on the as‐made Ba2+–Si4+ co‐substituted phosphor. X‐ray powder diffractometer and scanning electron microscopy images showed that the fluorescence crystals were less eroded and evenly dispersed in the glass matrix. Spectral analysis showed that the garnet phase was protected by using lead‐free borosilicate glass with a low melting point, and the quantum efficiency of phosphor‐in‐glass (PiG) retains 98% of the corresponding phosphor. By adjusting the ratio of garnet phosphor to commercial red nitride phosphors, a warm white fluorescence with a color rendering index of 80.3 and color temperature of 3899 K was obtained. The prepared warm white film has potential application value in the whole spectra field.
Factors influencing outcomes of surgical therapy of peri‐implantitis: A secondary analysis of 1‐year results from a randomized clinical study
Authors: Ichioka Yuki , Trullenque‐Eriksson Anna , Ortiz‐Vigón Alberto , Guerrero Adrián , Donati Mauro , Bressan Eriberto , Ghensi Paolo , Schaller Dennis , Tomasi Cristiano , Karlsson Karolina , Abrahamsson Ingemar , Dionigi Carlotta , Regidor Erik , Berglundh Tord , Derks Jan 
Published: July 2023

AbstractAimTo identify predictors of treatment outcomes following surgical therapy of peri‐implantitis.Materials and MethodsWe performed a secondary analysis of data from a randomized controlled trial (RCT) comparing access flap with or without bone replacement graft. Outcomes at 12 months were probing pocket depth (PPD), bleeding on probing (BOP), soft‐tissue recession (REC) and marginal bone level (MBL) change. Multilevel regression analyses were used to identify predictors. We also built an explanatory model for residual signs of inflammation.ResultsBaseline PPD was the most relevant predictor, showing positive associations with final PPD, REC and MBL gain, and negative association with probability of pocket closure. Smokers presented higher residual PPD. Absence of keratinized mucosa at baseline increased the probability of BOP but was otherwise not indicative of outcomes. Plaque at 6 weeks was detrimental in terms of residual PPD and BOP. Treatment allocation had an effect on REC. Final BOP was explained by residual PPD ≥6 mm and plaque at more than two sites.ConclusionsBaseline PPD was the most relevant predictor of the outcomes of surgical therapy of peri‐implantitis. Pocket closure should be a primary goal of treatment. Bone replacement grafts may be indicated in aesthetically demanding cases to reduce soft‐tissue recession. The importance of smoking cessation and patient‐performed plaque control is also underlined.
Investigation of dietary exogenous protease and humic substance on growth, disease resistance to Flavobacterium covae and immune responses in juvenile channel catfish (Ictalurus punctatus)
Authors: Oladipupo Abdulmalik A. , Kelly Anita M. , Davis D. Allen , Bruce Timothy J. 
Published: July 2023

AbstractMany bacterial pathogens impact the US catfish industry, and disease control can be challenging for producers. Columnaris disease in channel catfish, Ictalurus punctatus, is primarily caused by Flavobacterium covae (formerly F. columnare). Immunostimulants may enhance nonspecific immune responses and offer an alternative to antibiotic treatments in catfish. Furthermore, dietary protein sources and inclusions are also essential to fish health and nutrition and may enhance overall fish performance in pond culture. The current project evaluated two immunostimulants: a protease complex (PC) and a humic substance (HS) derived from a reed‐sedge peat product. A 60‐day trial examined the effects of five diets on growth performance, immune response and resistance to experimental F. covae infection in channel catfish. Diets included a high‐quality fishmeal diet (32%; CF32), a high‐protein soy‐based diet (32%; C32), a low‐protein soy‐based diet (28%; C28; predominately used in industry), a low‐protein soy diet supplemented with C28 + PC at 175 g metric ton−1 and C28 + HS in a low‐protein diet at 23 g metric ton−1. Following feeding for 60 d, juvenile channel catfish were sampled for growth performance and baseline health indicators (n = 3; body mucus, blood for sera, kidney and spleen). A subset of fish was then subjected to an immersion‐based in vivo challenge trial with F. covae (ALG‐00‐530; 106 CFU mL−1 exposure). At 60d post‐initiation, there were no dietary differences in the relative growth rate (p = .063) or thermal growth coefficient (p = .055), but the 32% diets generally appeared to perform best. Post‐challenge, the C32 group's mortality was higher than the C28 + PC (p = .006) and C28 + HS diets (p = .005). Although not significant, the C28 and CF32 groups also demonstrated higher mortality compared to both PC and HS diets. Sera lysozyme concentration was found to increase following pathogen challenge (p < .001) and in comparison with mock‐challenged catfish (p < .001). Elevated expression levels of proinflammatory cytokines (il‐1β, il‐8, tnf‐α and tgf‐β) were observed at trial midpoint and post‐infection when compared to 60d. The C28 treatment was found to have lower tnf‐α expression than the C28 + PC (p = .042) and C28 + HS (p = .042) groups following exposure to F. covae. These challenge data suggest that the immunostimulants (PC and HS) in plant‐based protein may be beneficial in protecting against F. covae when offered in low‐protein channel catfish diets.
Early emollient bathing is associated with subsequent atopic dermatitis in an unselected birth cohort study
Authors: O'Connor Cathal , Livingstone Vicki , O’B Hourihane Jonathan , Irvine Alan D. , Boylan Geraldine , Murray Deirdre 
Published: July 2023

AbstractBackgroundSkin barrier dysfunction is a key component of the pathogenesis of atopic dermatitis (AD). Recent research on barrier optimization to prevent AD has shown mixed results. The aim of this study was to assess the relationship between emollient bathing at 2 months and the trajectory of AD in the first 2 years of life in a large unselected observational birth cohort study.MethodsThe Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints Birth Cohort study enrolled 2183 infants. Variables extracted from the database related to early skincare, skin barrier function, parental history of atopy, and AD outcomes. Statistical analysis was performed to adjust for potential confounding variables.ResultsOne thousand five hundred five children had data on AD status available at 6, 12, and 24 months. Prevalence of AD was 18.6% at 6 months, 15.2% at 12 months, and 16.5% at 24 months. Adjusted for potential confounding variables, the odds of AD at any point were higher among infants who had emollient baths at 2 months (OR (95% CI): 2.41 (1.56 to 3.72), p < .001). Following multivariable analysis, the odds of AD were higher among infants who had both emollient baths and frequent emollient application at 2 months, compared with infants who had neither (OR (95% CI) at 6 months 1.74 (1.18–2.58), p = .038), (OR (95% CI) at 12 months 2.59 (1.69–3.94), p < .001), (OR (95% CI) at 24 months 1.87 (1.21–2.90), p = .009).ConclusionEarly emollient bathing was associated with greater development of AD by 2 years of age in this population‐based birth cohort study.