bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis
Authors: Conroy Andrea L. , Datta Dibyadyuti , Opoka Robert O. , Batte Anthony , Bangirana Paul , Gopinadhan Adnan , Mellencamp Kagan A. , Akcan-Arikan Ayse , Idro Richard , John Chandy C. 
Published: May 2023

IntroductionCerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies suggest acute kidney injury (AKI) is a risk factor for brain injury in cerebral malaria. The present study evaluates potential mechanisms of brain injury in cerebral malaria by evaluating changes in cerebrospinal fluid measures of brain injury with respect to severe malaria complications. Specifically, we attempt to delineate mechanisms of injury focusing on blood-brain-barrier integrity and acute metabolic changes that may underlie kidney-brain crosstalk in severe malaria.MethodsWe evaluated 30 cerebrospinal fluid (CSF) markers of inflammation, oxidative stress, and brain injury in 168 Ugandan children aged 18 months to 12 years hospitalized with cerebral malaria. Eligible children were infected with Plasmodium falciparum and had unexplained coma. Acute kidney injury (AKI) on admission was defined using the Kidney Disease: Improving Global Outcomes criteria. We further evaluated blood-brain-barrier integrity and malaria retinopathy, and electrolyte and metabolic complications in serum.ResultsThe mean age of children was 3.8 years (SD, 1.9) and 40.5% were female. The prevalence of AKI was 46.3% and multi-organ dysfunction was common with 76.2% of children having at least one organ system affected in addition to coma. AKI and elevated blood urea nitrogen, but not other measures of disease severity (severe coma, seizures, jaundice, acidosis), were associated with increases in CSF markers of impaired blood-brain-barrier function, neuronal injury (neuron-specific enolase, tau), excitatory neurotransmission (kynurenine), as well as altered nitric oxide bioavailability and oxidative stress (p &lt; 0.05 after adjustment for multiple testing). Further evaluation of potential mechanisms suggested that AKI may mediate or be associated with CSF changes through blood-brain-barrier disruption (p = 0.0014), ischemic injury seen by indirect ophthalmoscopy (p &lt; 0.05), altered osmolality (p = 0.0006) and through alterations in the amino acids transported into the brain.ConclusionIn children with cerebral malaria, there is evidence of kidney-brain injury with multiple potential pathways identified. These changes were specific to the kidney and not observed in the context of other clinical complications.
Scoping out noisy galvanic vestibular stimulation: a review of the parameters used to improve postural control
Authors: McLaren Ruth , Smith Paul F. , Taylor Rachael L. , Niazi Imran Khan , Taylor Denise 
Published: May 2023

ObjectiveNoisy galvanic vestibular stimulation (nGVS) has been used to facilitate vestibular function and improve gait and balance in people with poor postural control. The aim of this scoping review is to collate, summarize and report on the nGVS parameters that have been used to augment postural control.MethodA systematic scoping review was conducted up to December 2022. Data were extracted and synthesized from 31 eligible studies. Key nGVS parameters were identified, and the importance of these parameters and their influence on postural control evaluated.ResultsA range of nGVS parameters have been used to augment postural control, including; noise waveform, amplitude, frequency band, duration of stimulation, method of amplitude optimization, size and composition of electrodes and the electrode skin interface.ConclusionSystematic evaluation of the individual parameters that can be manipulated in the nGVS waveform identified that a broad array of settings have been utilized in each parameter across the studies. Choices made around the electrode and electrode-skin interface, as well as the amplitude, frequency band, duration and timing of the waveform are likely to influence the efficacy of nGVS. The ability to draw robust conclusions about the selection of optimal nGVS parameters to improve postural control, is hindered by a lack of studies that directly compare parameter settings or consider the variability in individuals’ response to nGVS. We propose a guideline for the accurate reporting of nGVS parameters, as a first step toward establishing standardized stimulation protocols.
Oncogenic role and drug sensitivity of ETV4 in human tumors: a pan-cancer analysis
Authors: Zhang Rui , Peng Yanfang , Gao Zhe , Qian Jing , Yang Kang , Wang Xinfa , Lu Wenjing , Zhu Yongjie , Qiu Dezhi , Jin Tong , Wang Gang , He Junping , Liu Ning 
Published: May 2023

BackgroundIncreasing evidence supports a relationship between E twenty-six variant transcription factor 4 (ETV4) and several cancers, but no pan-cancer analysis has been reported.MethodsThe present study surveyed the effects of ETV4 on cancer using RNA sequencing data obtained from The Cancer Genome Atlas and GTEx, and further explored its role in drug sensitivity using data from Cellminer. Differential expression analyses were conducted for multiple cancers using R software. Cox regression and survival analysis were employed to calculate correlations between ETV4 levels and survival outcomes in multiple cancers using the online tool Sangerbox. ETV4 expression was also compared with immunity, heterogeneity, stemness, mismatch repair genes, and DNA methylation among different cancers.ResultsETV4 was found to be significantly upregulated in 28 tumors. Upregulation of ETV4 was associated with poor overall survival, progression free interval, disease-free-interval, and disease specific survival in several cancer types. Expression of ETV4 was also remarkably correlated with immune cell infiltration, tumor heterogeneity, mismatch repair gene expression, DNA methylation, and tumor stemness. Furthermore, ETV4 expression seemed to affect sensitivity to a number of anticancer drugs.ConclusionsThese results suggest that ETV4 may be useful as a prognostic factor and therapeutic target.
Role of neuronavigation in the surgical management of brainstem gliomas
Authors: Zhang Mingxin , Xiao Xiong , Gu Guocan , Zhang Peng , Wu Wenhao , Wang Yu , Pan Changcun , Wang Liang , Li Huan , Wu Zhen , Zhang Junting , Zhang Liwei 
Published: May 2023

ObjectiveNeuroNavigation (NN) is a widely used intraoperative imaging guidance technique in neurosurgical operations; however, its value in brainstem glioma (BSG) surgery is inadequately reported and lacks objective proof. This study aims to investigate the applicational value of NN in BSG surgery.MethodA retrospective analysis was performed on 155 patients with brainstem gliomas who received craniotomy from May 2019 to January 2022 at Beijing Tiantan Hospital. Eighty-four (54.2%) patients received surgery with NN. Preoperative and postoperative cranial nerve dysfunctions, muscle strength, and Karnofsky (KPS) were evaluated. Patients’ radiological features, tumor volume, and extent of resection (EOR) were obtained from conventional MRI data. Patients’ follow-up data were also collected. Comparative analyses on these variables were made between the NN group and the non-NN group.ResultThe usage of NN is independently related to a higher EOR in diffuse intrinsic pontine glioma (DIPG) (p=0.005) and non-DIPG group (p&lt;0.001). It was observed that fewer patients in the NN group suffered from deterioration of KPS (p=0.032) and cranial nerve function (p=0.017) in non-DIPG group, and deterioration of muscle strength (p=0.040) and cranial nerve function (p=0.038) in DIPG group. Moreover, the usage of NN is an independent protective factor for the deterioration of KPS (p=0.04) and cranial nerve function (p=0.026) in non-DIPG patients and the deterioration of muscle strength (p=0.009) in DIPG patients. Furthermore, higher EOR subgroups were found to be independently related to better prognoses in DIPG patients (p=0.008).ConclusionNN has significant value in BSG surgery. With the assistance of NN, BSG surgery achieved higher EOR without deteriorating patients’ functions. In addition, DIPG patients may benefit from the appropriate increase of EOR.
Gustave Roussy immune score is a prognostic marker in patients with small cell lung cancer undergoing immunotherapy: a real-world retrospective study
Authors: Shangguan Jian , Huang Xinyi , Liu Xu , Zhang Zengfu , Zhang Xiaodong , Yu Jinming , Chen Dawei 
Published: May 2023

BackgroundThe utilization of the Gustave Roussy Immune Score (GRIm-Score) in patient selection for immunotherapy was initially reported. The objective of this retrospective study is to assess the potential of the GRIm-Score, a novel prognostic score based on nutritional and inflammatory markers, as a prognostic predictor in patients with small cell lung cancer (SCLC) undergoing immunotherapy.MethodsThis retrospective study conducted at a single center included 159 patients with SCLC who received immunotherapy. The objective of the study was to investigate potential differences in overall survival (OS) and progression-free survival (PFS) among patients stratified by their GRIm-Score, utilizing the Kaplan–Meier survival analysis and the log-rank test. The final independent prognostic factors were identified through both propensity score matching (PSM) analysis and multivariable Cox proportional hazards regression analysis.ResultsOur analysis of the 159 patients revealed that there was a significant decrease in both OS and PFS with each increase in the GRIm-Score group, displaying a stepwise pattern. Moreover, even after conducting PSM analysis, the significant associations between the modified three-category risk scale-based GRIm-Score and survival outcomes remained significant. Both the total cohort and PSM cohort were subjected to multivariable analysis, which demonstrated that the three-category risk assessment-based GRIm-Score was a valuable predictor of both OS and PFS.ConclusionsIn addition, the GRIm-Score may serve as a valuable and non-invasive prognostic predictor for SCLC patients undergoing PD1/PD-L1 immunotherapy.
Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis
Authors: Tian Siyu , Zhang Hang , Chen Siqi , Wu Pengning , Chen Min 
Published: May 2023

Background: Irritable bowel syndrome (IBS) is a group of functional intestinal disorders characterized by abdominal pain, bloating, and changes in bowel habits, and/or stool characteristics. Recent studies have shown that there has been a significant advancement in the study of visceral hypersensitivity in IBS. Through the use of bibliometrics, this study aims to provide a comprehensive overview of the knowledge structure and research hotpots of visceral hypersensitivity in IBS.Methods: Publications related to visceral hypersensitivity in IBS from 2012 to 2022 were searched on the web of science core collection (WoSCC) database. CiteSpace.6.1. R2 and Vosviewer 1.6.17 were used to perform bibliometric analysis.Results: A total of 974 articles led by China and the United States from 52 countries were included. Over the past decade, the number of articles on visceral hypersensitivity and IBS has steadily increased year by year. China, the United States, and Belgium are the main countries in this field. Univ Oklahoma, Univ Gothenburg, and Zhejiang University are the main research institutions. Simren, Magnus, Greenwood-van meerveld, Beverley, and Tack, Jan are the most published authors in this research field. The research on the causes, genes, and pathways involved in visceral hypersensitivity in IBS and the mechanism of IBS are the main topics and hotspots in this field. This study also found that gut microbiota may be related to the occurrence of visceral hypersensitivity, and probiotics may be a new method for the treatment of visceral hypersensitivity and pain, which may become a new direction for research in this field.Conclusion: This is the first bibliometric study to comprehensively summarize the research trends and developments of visceral hypersensitivity in IBS. This information provides the research frontier and hot topics in this field in recent years, which will provide a reference for scholars studying this field.
Effects of positive end-expiratory pressure on cerebral hemodynamics in acute brain injury patients
Authors: Giardina Alberto , Cardim Danilo , Ciliberti Pietro , Battaglini Denise , Ball Lorenzo , Kasprowicz Magdalena , Beqiri Erta , Smielewski Peter , Czosnyka Marek , Frisvold Shirin , Groznik Matjaž , Pelosi Paolo , Robba Chiara 
Published: May 2023

Background: Cerebral autoregulation is the mechanism that allows to maintain the stability of cerebral blood flow despite changes in cerebral perfusion pressure. Maneuvers which increase intrathoracic pressure, such as the application of positive end-expiratory pressure (PEEP), have been always challenged in brain injured patients for the risk of increasing intracranial pressure (ICP) and altering autoregulation. The primary aim of this study is to assess the effect of PEEP increase (from 5 to 15 cmH2O) on cerebral autoregulation. Secondary aims include the effect of PEEP increase on ICP and cerebral oxygenation.Material and Methods: Prospective, observational study including adult mechanically ventilated patients with acute brain injury requiring invasive ICP monitoring and undergoing multimodal neuromonitoring including ICP, cerebral perfusion pressure (CPP) and cerebral oxygenation parameters obtained with near-infrared spectroscopy (NIRS), and an index which expresses cerebral autoregulation (PRx). Additionally, values of arterial blood gases were analyzed at PEEP of 5 and 15 cmH2O. Results are expressed as median (interquartile range).Results: Twenty-five patients were included in this study. The median age was 65 years (46–73). PEEP increase from 5 to 15 cmH2O did not lead to worsened autoregulation (PRx, from 0.17 (−0.003–0.28) to 0.18 (0.01-0.24), p = 0.83). Although ICP and CPP changed significantly (ICP: 11.11 (6.73–15.63) to 13.43 (6.8–16.87) mm Hg, p = 0.003, and CPP: 72.94 (59.19–84) to 66.22 (58.91–78.41) mm Hg, p = 0.004), these parameters did not reach clinically relevant levels. No significant changes in relevant cerebral oxygenation parameters were observed.Conclusion: Slow and gradual increases of PEEP did not alter cerebral autoregulation, ICP, CPP and cerebral oxygenation to levels triggering clinical interventions in acute brain injury patients.
Visual biases in evaluation of speakers’ and singers’ voice type by cis and trans listeners
Authors: Marchand Knight Jay , Sares Anastasia G. , Deroche Mickael L. D. 
Published: May 2023

IntroductionA singer’s or speaker’s Fach (voice type) should be appraised based on acoustic cues characterizing their voice. Instead, in practice, it is often influenced by the individual’s physical appearance. This is especially distressful for transgender people who may be excluded from formal singing because of perceived mismatch between their voice and appearance. To eventually break down these visual biases, we need a better understanding of the conditions under which they occur. Specifically, we hypothesized that trans listeners (not actors) would be better able to resist such biases, relative to cis listeners, precisely because they would be more aware of appearance-voice dissociations.MethodsIn an online study, 85 cisgender and 81 transgender participants were presented with 18 different actors singing or speaking short sentences. These actors covered six voice categories from high/bright (traditionally feminine) to low/dark (traditionally masculine) voices: namely soprano, mezzo-soprano (referred to henceforth as mezzo), contralto (referred to henceforth as alto), tenor, baritone, and bass. Every participant provided voice type ratings for (1) Audio-only (A) stimuli to get an unbiased estimate of a given actor’s voice type, (2) Video-only (V) stimuli to get an estimate of the strength of the bias itself, and (3) combined Audio-Visual (AV) stimuli to see how much visual cues would affect the evaluation of the audio.ResultsResults demonstrated that visual biases are not subtle and hold across the entire scale, shifting voice appraisal by about a third of the distance between adjacent voice types (for example, a third of the bass-to-baritone distance). This shift was 30% smaller for trans than for cis listeners, confirming our main hypothesis. This pattern was largely similar whether actors sung or spoke, though singing overall led to more feminine/high/bright ratings.ConclusionThis study is one of the first demonstrations that transgender listeners are in fact better judges of a singer’s or speaker’s voice type because they are better able to separate the actors’ voice from their appearance, a finding that opens exciting avenues to fight more generally against implicit (or sometimes explicit) biases in voice appraisal.
The effects of Latino Dance intervention on academic and general self-efficacy with left-behind children: An experimental study in China
Authors: Zhou Zhenqian , Zhou Yutao , Ferraro Francesco Vincenzo , Hooton Andy , Ribchester Chris 
Published: May 2023

IntroductionAlthough there is considerable research indicating that physical exercise and dance can strengthen children’s self-efficacy, and children’s self-efficacy can predict students’ academic achievement at a wide range of academic levels. Few studies have been conducted using Latino Dance to improve self-efficacy in Left-Behind Children (LBC), especially the two aspects of student academic self-efficacy and general self-efficacy, while the mediator role of self-esteem between student academic self-efficacy and general self-efficacy has been less explored in previous research.MethodsThis study proposed to examine Latino Dance interventions to improve general self-efficacy and students’ academic self-efficacy among LBC students in rural areas to boost students’ academic performance, and the research team hypothesised that general self-efficacy, students’ academic self-efficacy and self-esteem would improve following the intervention and that outcomes will have a significant positive correlation as students’ self-esteem can mediate both their academic self-efficacy and their general self-efficacy. Dates were collected from 305 LBCs children (160 boys and 145 girls) from 6 left-behind schools in Hunan province, China. Ralf Schwarzer’s general self-efficacy scale, Morgan-Jinks Student academic Self-Efficacy Scale, and Rosenberg’s self-esteem scale were administered to LBCs between September 2020 and January 2022.ResultsThe results revealed that the Latino Dance intervention significantly increased the LBC student’ academic self-efficacy and general self-efficacy, which also involved a positive effect on the three sub-dimensions (talent, context, and effort) of students’ academic self-efficacy. Further, multiple linear regression analysis confirmed that self-esteem (positive esteem/self-deprecation) acted as a partial mediator between student academic self-efficacy and general self-efficacy; perceived self-esteem played a mediating role between them.DiscussionThis study filled a gap in the literature concerning the psychological reinforcement effect of Latino Dance on LBC groups and demonstrated that Latino Dance improved the student’ academic self-efficacy and general self-efficacy among the LBCs. Our results suggest that Latino Dance can be beneficial for LBC in school by including Latino Dance in Physical Education or Art courses and improving students’ self-esteem may lead to an increase in student academic self-efficacy as well as general self-efficacy, thereby improving and enhancing the learning of LBCs.
Translation directionality and the Inhibitory Control Model: a machine learning approach to an eye-tracking study
Authors: Chang Vincent Chieh-Ying , Chen I-Fei 
Published: May 2023

IntroductionBased on such physiological data as pupillometry collected in an eye-tracking experiment, the study has further confirmed the effect of directionality on cognitive loads during L1 and L2 textual translations by novice translators, a phenomenon called “translation asymmetry” suggested by the Inhibitory Control Model, while revealing that machine learning-based approaches can be usefully applied to the field of Cognitive Translation and Interpreting Studies.MethodsDirectionality was the only factor guiding the eye-tracking experiment where 14 novice translators with the language combination of Chinese and English were recruited to conduct L1 and L2 translations while their pupillometry were recorded. They also filled out a Language and Translation Questionnaire with which categorical data on their demographics were obtained.ResultsA nonparametric related-samples Wilcoxon signed rank test on pupillometry verified the effect of directionality, suggested by the model, during bilateral translations, verifying “translation asymmetry” at atextuallevel. Further, using the pupillometric data, together with the categorical information, the XGBoost machine-learning algorithm yielded a model that could reliably and effectively predict translation directions.ConclusionThe study has shown that translation asymmetry suggested by the model was valid at atextuallevel, and that machine learning-based approaches can be gainfully applied to Cognitive Translation and Interpreting Studies.
Prevalence of suicide ideation, self-harm, and suicide among Chinese patients with schizophrenia: a systematic review and meta-analysis
Authors: Liang Yiying , Wu Manqi , Zou Yanqiu , Wan Xiaoyan , Liu Yuanyuan , Liu Xiang 
Published: May 2023

AimsSuicide ideation, self-harm, and suicide are common in patients with schizophrenia, but the reported prevalence vary largely across studies. Improved prevalence estimates and identification of moderators of the above self-directed violence are needed to enhance recognition and care, and to guide future management and research. This systematic review aims to estimate the pooled prevalence and identify moderators of suicide ideation, self-harm, and suicide among patients diagnosed with schizophrenia in China.MethodsRelevant articles published until September 23, 2021, were searched using PubMed, EBSCO, Web of Science, Embase, Science Direct, CNKI, CBM, VIP, and Wanfang databases. Eligible studies published in English or Chinese which reported the prevalence of suicide ideation, self-harm, or suicide among Chinese patients with schizophrenia were collected. All studies passed a quality evaluation. This systematic review was registered with PROSPERO (registration number CRD42020222338). PRISMA guidelines were used in extracting and reporting data. Random-effects meta-analyses were generated using the meta package in R.ResultsA total of 40 studies were identified, 20 of which were evaluated as high-quality studies. Based on these studies, the prevalence of lifetime suicide ideation was 19.22% (95% CI: 7.57–34.50%), prevalence of suicide ideation at the time of investigation was 18.06% (95% CI: 6.49–33.67%), prevalence of lifetime self-harm was 15.77% (95% CI: 12.51–19.33%), and prevalence of suicide was 1.49% (95% CI: 0.00–7.95%). Multivariate meta-regression analysis revealed that age (β = − 0.1517, p = 0.0006) and dependency ratio (β = 0.0113, p &lt; 0.0001) were associated with the lifetime prevalence of self-harm. Study assessment score (β = 0.2668, p &lt; 0.0001) and dependency ratio (β = 0.0050, p = 0.0145) were associated with the lifetime prevalence of suicide ideation. Results of the spatial analysis showed that the prevalence of self-directed violence varied greatly across different provinces.ConclusionThis systematic review provides estimates of the prevalence of self-directed violence among Chinese patients with schizophrenia and explores its moderators and spatial patterns. Findings also have important implications for allocating prevention and intervention resources to targeted high-risk populations in high prevalence areas.