bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke induces early recurrent vascular events by inflammasome-dependent atherosclerotic plaque rupture
Authors: Liesz Arthur , Cao Jiayu , Roth Stefan , Zhang Sijia , Kopczak Anna , Georgakis Marios , Li Xinghai , Dutsch Alexander , Liman Thomas , Endres Matthias , Brough David , Green Jack , Wernsdorf Saskia , Fürle Christina , Carofiglio Olga , Zhu Jie , Asare Yaw , Group DEMDAS Study , Dichgans Martin , Sager Hendrik , Grosse Gerrit 
Published: March 2023

Abstract

The risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients experiencing early recurrent events. However, despite the enormous medical burden of this clinical phenomenon, the underlying mechanisms leading to increased vascular risk and recurrent stroke are largely unknown. Here, using a novel mouse model of stroke-induced recurrent ischemia, we show that stroke leads to activation of the AIM2 inflammasome in vulnerable atherosclerotic plaques via an increase of circulating cell-free DNA from the ischemic tissue. Enhanced plaque inflammation post-stroke results in plaque destabilization and atherothrombosis, finally leading to arterio-arterial embolism and recurrent stroke within days after the index stroke. We confirm key steps of plaque destabilization also after experimental myocardial infarction and in carotid artery plaque samples from patients with acute stroke. Neutralization of cell-free DNA by DNase treatment or inhibition of inflammasome activation reduced the rate of stroke recurrence after experimental stroke. Our findings present an explanation for the high recurrence rate after incident ischemic events in atherosclerotic patients. The detailed mechanisms uncovered here provide so far clinically uncharted therapeutic targets for which we show high efficacy to prevent recurrent events. Targeting DNA-mediated inflammasome activation after remote tissue injury represents a promising avenue for further clinical development in the prevention of early recurrent events.
Novel Hybrid-Relay Cooperative Communications Technique for Agriculture .
Authors: Kalu Chikezie Kennedy , Sakilu Olani Bekele , Ebhota Simeon 
Published: March 2023

Abstract
Objective – To investigate, and analyse the novel Hybrid-Relay Cooperative communications technique and algorithms which provides the possibility of obtaining improved system performance, with minimal cost, complexities, and overall energy consumption in wireless fading channels while retaining spectral efficiency to aid decision making processes for a more efficient and effective water-agriculture-food nexus.
Methods– Henceforth, the comparative performance and energy efficiency analysis of the fundamental cooperative MIMO techniques namely: Detect & Forward (DF), Amplify & Forward (AF) and the Coded cooperation were analysed with respect to the Hybrid Cooperative Communications technique. The methodical and data-driven analyses were carried out using MATLAB and Wireless Communications Systems Parameters.
Results – In harmony with the ‘Green Communications’ wireless communication theme; the excellent trade – off between performance (data rate) and energy efficiency is confirmed, which of course creates very good potential for use for an improved agricultural monitoring and management system.
Conclusion – The Hybrid-Relay Cooperative communications system serves as a basis for the comparative analysis of the aforementioned cooperative MIMO techniques and provides fundamental, but meaningful deductions and potentials with regards to efficient cooperative communications for innovative, efficient and effective water management for improved agricultural practices and a sustainable environment.
TOOL: MATLAB.
An Intelligent Cloud Broker with Service Ranking Algorithm for Validation and Verification of Cloud Services in Multi-cloud Environment
Authors: Nagarajan Rajganesh , P Vinothiyalakshmi , Thirunavukarasu Ramkumar 
Published: March 2023

Abstract
Cloud computing offers a widespread variety of services for the users. In multi-cloud environment, the service centric features are introduced to assist the cloud users from the multiple endpoints. In order to enhance the service availability, cloud brokerage is introduced into the multi-cloud environment that outperforms the effective utilization of required services. The primary objective of a cloud broker is to ensure about the services and its outcomes while offering them to a customer. The role of a traditional broker has the restrictions such as measuring the service trust, validity, and the future enhancement of the considered cloud services from the multi-cloud environment. Hence, the need for the intelligence feature is highly solicited in the cloud broker while working in a multi-cloud environment. The proposed intelligent cloud broker performs the validation and verification of service trust details by analysing the service trust factors such as service response time, sustainability, suitability, accuracy, transparency, interoperability, availability, reliability, stability, cost, throughput, efficiency, scalability of the cloud services. The customer’s feedback is taken into consideration for measuring the service trust factors before the service recommendation. In this proposed model, the Service Ranking (SR) values are calculated for the available cloud services. Additionally, the proposed model considers the newly arrived services during cloud services validation process by mapping its services with the available cloud services from the Service Collection Repository (SCR). Hence, this proposed model outperforms well in the process of recommending services to the cloud users.
Branch Retinal Vein Occlusion Treated with Anti VEGF, to Switch or not to Switch? Long Term Follow-Up
Authors: Shor Reut , Segal Ori , Greenbaum Eran , Cohen Ram , Trivizki Omer , schwartz shulamit , Loewenstein Anat , Rabina Gilad 
Published: March 2023

Abstract
Objectives
To evaluate visual outcomes after switching from Bevacizumab to Ranibizumab or Aflibercept in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO).
Methods
A retrospective, multi-center, observational study of BRVO patients treated with at least three Bevacizumab injections, prior to anti VEGF switch. Follow up period was 36 months and the primary study outcomes assessed changes in best corrected visual acuity (BCVA) after anti VEGF switch.
Results
A total of 263 eyes of 263 patients with a mean age of 71.5 ± 11.2 years of which 50% were of male gender met the inclusion criteria. Of these 175 eyes did not underwent switch while 88 eyes underwent anti-VEGF switch. There was not significant difference in mean age (p = 0.634) and gender (p = 0.269) between groups. Baseline BCVA of the no-switch group was 0.47 ± 0.43 logMAR (20/59 Snellen) Vs. 0.6 ± 0.49 logMAR (20/79 Snellen) (p = 0.031) in the switch group and at 36-months it was 0.41 ± 0.39 (20/51 Snellen) logMAR Vs. 0.54 ± 0.49 logMAR (20/69 Snellen) (p = 0.035) respectively. Difference between the rate of change in BCVA per year was insignificant between groups (p = 0.414). in multivariate analysis baseline BCVA was the single significant predictor for switch (Beta 0.137, p = 0.035). Patients with more than one anti VEGF switch suffer from decrease in BCVA.
Conclusions
Worse BCVA is a significant predictor for anti-VEGF switch execution, though the switch has no significant impact on the change in BCVA over time. Multiple anti VEGF switch is not recommended.
Prognosis nomogram for transhepatic arterial chemoembolisation with 125I seed implantation for first-branch portal vein tumour thrombus hepatocellular carcinoma：a comparative study of two statistical analysis methods
Authors: Zhao Xiao-Hui , Zhang Li-Lin , Zhao Lei , Zhao Yan , Li Hai-Liang , Cao Guang-Shao , Xu Shi-Jun , Guo Yuan , Hu Hong-Tao 
Published: March 2023

Abstract
Purpose: To investigate the efficacy of transhepatic arterial chemoembolisation (TACE) combined with 125I seed implantation in patients with first-branch portal vein tumour thrombus (PVTT) hepatocellular carcinoma (HCC), we tried to establish a nomogram to determine the prognosis of individual patients by comparing different statistical methods.
Materials and Methods: 97 patients who underwent TACE combined with PVTT 125I seed implantation served as the primary cohort. The median overall survival (mOS) was the main indicator of prognosis nomogram. Univariate analysis and LASSO regression were used to screen for variables. Selected variables were included in the multivariate Cox survival regression model, and a prognostic nomogram was developed. The performance of the nomogram was assessed in terms of calibration, discrimination, and clinical usefulness. The internal and external verifications were also evaluated.
Results: The mOS of all patients was 12.5 months (95%CI: 11.78–13.22). The final determination was made using the tumour burden, PVTT types, and platelet (PLT) count to establish a nomogram prediction model [C-index: 0.770 (95% confidence interval: 0.723–0.817)]. This model demonstrated good discrimination and calibration. Application of the nomogram to external verification data still yielded good discrimination [C-index: 0.764] and good calibration. The decision curve analysis demonstrated that the clinical validity of the model was clinically useful.
Conclusion: This nomogram can be used to predict the prognostic survival time of such patients and can help doctors make decisions in clinical practice. At the same time, the appropriate statistical methods should be selected based on clinical needs.
Comprehensive Analysis of Long Non-coding RNA,miRNA，and mRNA-associated Competitive Endogenous RNA Networks in the Peripheral Blood of Preterm Infants with Bronchopulmonary Dysplasia
Authors: Wang Yayun , Wei Yuqing , Ma Hongfang , Zhang Xue , Zhu Xiaobo , Xue Jiang , Wang Yibiao , Li Yufeng 
Published: March 2023

Abstract
Background: Bronchopulmonary dysplasia (BPD) is a complex disorder resulting from interactions between genes and the environment. The precise molecular etiology of BPD remains unclear. This study aimed to determine potential biomarkers and possible therapeutic targets of BPD through competitive endogenous RNA (ceRNA) network analysis and lay the foundation for future clinical research.
Methods: First, we downloaded the mRNA, miRNA, and long non-coding RNA (lncRNA) expression profiles of patients with BPD from the Comprehensive Gene Expression Database. We identified differentially expressed genes (DEGs), followed by functional enrichment analysis, construction of a protein-protein interaction network, and construction of ceRNA network.
Results: We obtained1286 DEGs, 77 differentially expressed miRNAs, and 104 differentially expressed lncRNAs. Functional enrichment analysis showed that DEGs were mainly involved in B-cell receptor signaling pathways, asthma, FcRI signaling pathways, cell apoptosis, the intestinal immune network that produces IgA, and Th17 cell differentiation signaling pathways. We constructed ceRNA network based on the predicted relationship between lncRNA-miRNA and mRNA-miRNA, including 6 lncRNAs, 11 miRNAs, and 56 mRNAs.
Conclusion: Through ceRNA network analysis, we identified six new lncRNAs that are potential biomarkers and therapeutic targets of BPD, thus opening up a new horizon for the prevention and treatment of BPD.
Development and Standardization of Gurukula Kangri Metacognition Awareness Scale in Higher Education Students
Authors: Kumar Narottam , Singh Udham 
Published: March 2023

Abstract
Authors have advocated for the inclusion of spiritual cognition awareness (SCA) as a domain in metacognition with metacognitive knowledge (MCK) and metacognitive regulation (MCR). It is in our understanding the knowledge comes from within (i.e., spirituality) are the innate ability to know and regulate own cognitive process. Previous literature supports the notion that spirituality has positive effect in students’ cognition, thus enhances their learning. The self-report assessment to measure metacognition as domain-specific ability associated to spiritual cognition (knowledge) is not found in previous literature. The authors have included the spiritual cognitive awareness as a domain in metacognition based on spiritual cognition theory, while tracing the descriptions as delineated in Indian psychological roots. This study elaborates the construction, development, and standardization of the 45-item Gurukula Kangri Metacognition awareness scale (GKMAS). The different properties of scale were confirmed by content validity, face validity (cognitive interview), demonstration of reliability (internal consistency, test-retest, split half), convergent validity and discriminant validity. The rigorous literature review has been carried out (for inclusion) before starting content and face validation process to fit SCA into metacognition. The 45-item GKMAS was administered on total 457 higher education students, received acceptable Cronbach’s alpha value for GKMAS and its SCA, MCK, and MCR. The study has also discussed implications of GKMAS in academic and corporate settings.
Remote imprinting of moiré lattices
Authors: Gu Jie , Watanabe Kenji , Taniguchi Takashi , Shan Jie , Mak Kin Fai 
Published: March 2023

Abstract
Two-dimensional (2D) moiré materials have emerged as an exciting platform for discoveries of new physics and device concepts 1-6. These materials are formed by overlaying two layered crystals with small differences in orientation or/and lattice constant, the direct coupling of which generates moiré potentials. The moiré materials (such as doping density) are highly tunable, but the moiré lattices, once formed, cannot be easily altered. Here we demonstrate electrostatic imprinting of moiré lattices onto a monolayer semiconductor. The moiré potential is created by a lattice of electrons that is supported by a Mott insulator state in a remote MoSe2/WS2 moiré layer. The imprinted moiré potential generates flat bands and correlated insulating states in the target material, which are detected by an exciton sensor. It can be turned on/off by a gate voltage that controls the doping density only in the moiré layer. We also illustrate the interplay between the electrostatic and structural relaxation effects for moiré imprinting as a function of the target and moiré layer spacing. Our results demonstrate a pathway towards the gate control of moiré lattices, including currently inaccessible symmetries, in an arbitrary 2D semiconductor or semimetal.
Designing, implantation and evaluation of a pediatric fever management program for nursing students: a mixed methods study
Authors: heidari haydeh , Saidi Reza 
Published: March 2023

Abstract
Background: Fever is one of the most common symptoms in children. However, the level of knowledge of nurses and parents regarding fever management is lower than expected. This study was conducted with the aim of developing a pediatric fever management program for nursing students.
Methods: This study applied exploratory mixed method which included 3 stages: developing a pediatric fever management plan and teaching this educational plan to 100 nursing students, interviewing with 20 students and parents regarding fever management plan, and designing a questionnaire and evaluating the opinions of students regarding the fever management plan. Participants included nursing students who were attending in pediatric internship course and parents of febrile children hospitalized in pediatrics unit. Data were analyzed using qualitative and quantitative data analysis methods.
Results: after analyzing qualitative data, three main themes identified: improving self-management ability in nursing students and parents of feverish children, behavior change and improving practices of students and parents. Quantitative results showed that, most participant completely agreed that, in the fever management plan, enough attention is paid to parents’ needs, the fever management plan leads to modification of parent practices regarding fever management, the fever management plan leads to behavioral changes in parents and 4. Generally, the fever management plan was satisfactory.
Conclusion: Results of our study showed that a pediatric fever management plan improved knowledge, self-management ability and practices of nursing students and parents of febrile children. These results can be used by healthcare managers for improving quality of cares given to febrile children.
Appendiceal Phlegmon as an intraoperative finding: A retrospective analysis
Authors: Conde Danny , Rodríguez Lina , Venegas David , Rey Carlos , Núñez-Rocha Ricardo E. , Nassar Ricardo , Vanegas Marco , Monsalve Catalina , Pinzón Pablo , Girón Felipe 
Published: March 2023

Abstract
Background
Emergency procedures due to acute surgical abdomen correspond to a great part of emergency surgeries. Appendicitis is the most common abdominal surgical emergency in the world. Intraoperative findings can represent a challenging scenario for the surgical team and its decisions. Appendiceal phlegmon/plastron presents in 3.8-7% of patients with appendicitis and can be considered as a challenging surgical scenario where expertise may gain a fundamental value in terms of decision-making process. Therefore, we present clinical courses and outcomes of 40 patients that underwent emergency surgery with these intraoperative findings from 2016 to 2018.
Methods
Retrospective study with a prospective database in which we described patients with emergent need for surgical procedure due to peritoneal signs with surgical findings of appendiceal phlegmon. Multivariate analysis was performed to prove the relationship between obesity, diabetes, and surgeon experience with any complication and colonic resection.
Results
40 patients underwent surgical procedure due to peritoneal signs with intraoperative findings of appendiceal phlegmon. Mean age was 51.9 (± 20.4). Procedures were performed based on intraoperative findings being appendectomy the most frequent (85%), followed by right hemicolectomy (10%) and partial cecum resection (5%). Three patients required reintervention. No mortalities were documented. Surgeries performed by junior surgeons have a higher probability to require colonic resections (P = 0.05, OR 4.05 ,95% CI), also obesity is associated with complications (P = 0.04, OR 1.44, 95% CI).
Conclusion
Finding of appendiceal phlegmon constitute a challenging surgical scenario in daily practice. Our patient’s complication rates are similar to those described in literature despite its emergent circumstances. Surgeons' expertise appears to be associated with outcomes. Further studies are needed to give clear recommendations.
Daisy Leaf Gentian Antagonism Protects against Adriamycin-induced Heart Failure in Mice
Authors: Liu Ying , Hou Xuxiao , Li Yunfeng , Zhao Jingshan , Liu Yalei , Liu Yu , Wang Haijun 
Published: March 2023

Abstract
Objective: This study aimed to evaluate the protective effect and underlying mechanisms of daisy leaf gentian, also known as bellidifolin (BEL), against heart injury in mice.
Methods: Mice were randomly divided into four groups: Control, ADM (ADM alone), ADM+BEL (ADM plus daisy leaf gentian ketone monomer), and ADM+CAP (ADM plus captopril). We sacrificed mice using cervical dislocation.Heart structure and function were evaluated using echocardiography and hemodynamic testing. The serum levels of creatine kinase,aspartate aminotransferase, lactate dehydrogenase, and brain natriuretic peptide were measured using enzyme-linked immunosorbent assays. Hematoxylin and eosin staining and Masson’s staining were used to detect myocardial pathological changes. TUNEL staining and electron microscopy were used to detect cardiomyocyte apoptosis. Transmission electron microscopy was used to observe ultrastructural changes in the cardiomyocyte nuclei and mitochondria.Immunohistochemical analysis,Western blot and real-time PCR assays were used to measure protein expression and mRNA levels of myocardial factors.
Results: ADM induced chronic heart failure in mice, and BEL improved the heart function in ADM-treated mice. Cardiomyocyte apoptosis was significantly increased in the ADM group, but apoptosis in the ADM+BEL and ADM+CAP groups was significantly reduced compared with the model animals. mRNA levels and protein expression of 78-kD glucose-regulated protein,brain natriuretic peptide,caspase-12, and phosphorylated eukaryotic cell translation initiation factor 2α were significantly higher in the ADM group. BEL or CAP successfully suppressed ADM-induced upregulation of these genes.
Conclusions: Daisy leaf gentian improved heart function and reduced cardiomyocyte apoptosis in mice following ADM-induced heart failure. The cardioprotective effect of daisy leaf gentian may be related to endoplasmic reticulum stress.
Boys Do Cry: Influences of Masculinity &amp; Avoidant-Attachment Style on Post-Romantic Breakup Emotional Distress
Authors: Sherwood Morgen Joy , Steele Howard , Kathuria Chirinjeev 
Published: March 2023

Abstract
This investigation sought to replicate Simpson’s 1990 study “Influence of Attachment Styles on Romantic Relationships,” which found attachment style to be uncorrelated to intensity of emotional distress following a romantic breakup, except in avoidant men— who experienced significantly less emotional distress than all other people including avoidant women, even when relationship length and quality were statistically controlled. With updated measures for attachment style, emotional distress, and a more diverse sample, this study found Simpson’s result irreplicable. Of 488 individuals who had previously disbanded from a romantic partner, ex-partners with anxious tendencies experienced more emotional distress than ex-partners with avoidant tendencies, but highly avoidant men did not experience significantly less emotional distress than highly avoidant women. Gender did not have a significant effect on levels of emotional distress, even when participants shared similar levels of anxiety and avoidance. Discussion focuses on possible reasons for the newfound lack of gender difference among highly avoidantly-attached individuals, emotionality in relation to societal gender norms, and the role of attachment in romantic relationship breakups.