bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of Muscle Apolipoprotein E Expression with Markers of Cellular Stress, Metabolism, and Blood Biomarkers in Cognitively Healthy and Impaired Older Adults
Authors: Johnson Chelsea N. , McCoin Colin S. , Kueck Paul J. , Hawley Amelia G. , John Casey S. , Thyfault John P. , Swerdlow Russell H. , Geiger Paige C. , Morris Jill K. 
Published: February 2023

Background: Individuals with mild cognitive impairment (MCI) have reduced lipid-stimulated mitochondrial respiration in skeletal muscle. A major risk factor for Alzheimer’s disease (AD), the apolipoprotein E4 ( APOE4) allele, is implicated in lipid metabolism and is associated with metabolic and oxidative stress that can result from dysfunctional mitochondria. Heat shock protein 72 (Hsp72) is protective against these stressors and is elevated in the AD brain. Objective: Our goal was to characterize skeletal muscle ApoE and Hsp72 protein expression in APOE4 carriers in relationship to cognitive status, muscle mitochondrial respiration and AD biomarkers. Methods: We analyzed previously collected skeletal muscle tissue from 24 APOE4 carriers (60y+) who were cognitively healthy (CH, n = 9) or MCI ( n = 15). We measured ApoE and Hsp72 protein levels in muscle and phosphorylated tau181 (pTau181) levels in plasma, and leveraged previously collected data on APOE genotype, mitochondrial respiration during lipid oxidation, and VO2 max. Results: Muscle ApoE ( p = 0.013) and plasma pTau181 levels ( p < 0.001) were higher in MCI APOE4 carriers. Muscle ApoE positively correlated with plasma pTau181 in all APOE4 carriers (R2 = 0.338, p = 0.003). Hsp72 expression negatively correlated with ADP (R2 = 0.775, p = <0.001) and succinate-stimulated respiration (R2 = 0.405, p = 0.003) in skeletal muscle of MCI APOE4 carriers. Plasma pTau181 negatively tracked with VO2 max in all APOE4 carriers (R2 = 0.389, p = 0.003). Analyses were controlled for age. Conclusion: This work supports a relationship between cellular stress in skeletal muscle and cognitive status in APOE4 carriers.
Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer’s Disease
Authors: Acosta-Baena Natalia , Lopera-Gómez Carlos M. , Jaramillo-Elorza Mario C. , Velilla-Jiménez Lina , Villegas-Lanau Carlos Andrés , Sepúlveda-Falla Diego , Arcos-Burgos Mauricio , Lopera Francisco 
Published: February 2023

Background: Depression is associated with Alzheimer’s disease (AD). Objective: To evaluate the association between depressive symptoms and age of onset of cognitive decline in autosomal dominant AD, and to determine possible factors associated to early depressive symptoms in this population. Methods: We conducted a retrospective study to identify depressive symptoms among 190 presenilin 1 ( PSEN1) E280A mutation carriers, subjected to comprehensive clinical evaluations in up to a 20-year longitudinal follow-up. We controlled for the following potential confounders: APOE, sex, hypothyroidism, education, marital status, residence, tobacco, alcohol, and drug abuse. Results: PSEN1 E280A carriers with depressive symptoms before mild cognitive impairment (MCI) develop dementia faster than E280A carriers without depressive symptoms (Hazard Ratio, HR = 1.95; 95% CI, 1.15–3.31). Not having a stable partner accelerated the onset of MCI (HR = 1.60; 95 % CI, 1.03–2.47) and dementia (HR = 1.68; 95 % CI, 1.09–2.60). E280A carriers with controlled hypothyroidism had later age of onset of depressive symptoms (HR = 0.48; 95 % CI, 0.25–0.92), dementia (HR = 0.43; 95 % CI, 0.21–0.84), and death (HR = 0.35; 95 % CI, 0.13–0.95). APOE ɛ2 significantly affected AD progression in all stages. APOE polymorphisms were not associate to depressive symptoms. Women had a higher frequency and developed earlier depressive symptoms than men throughout the illness (HR = 1.63; 95 % CI, 1.14–2.32). Conclusion: Depressive symptoms accelerated progress and faster cognitive decline of autosomal dominant AD. Not having a stable partner and factors associated with early depressive symptoms (e.g., in females and individuals with untreated hypothyroidism), could impact prognosis, burden, and costs.
Cognitive and Neuropsychological Profiles in Alzheimer’s Disease and Primary Age-Related Tauopathy and the Influence of Comorbid Neuropathologies
Authors: Walker Jamie M. , Gonzales Mitzi M. , Goette William , Farrell Kurt , White III Charles L. , Crary John F. , Richardson Timothy E. 
Published: February 2023

Background: Alzheimer’s disease neuropathologic change (ADNC) is defined by the progression of both hyperphosphorylated-tau (p-tau) and amyloid-β (Aβ) and is the most common underlying cause of dementia worldwide. Primary age-related tauopathy (PART), an Aβ-negative tauopathy largely confined to the medial temporal lobe, is increasingly being recognized as an entity separate from ADNC with diverging clinical, genetic, neuroanatomic, and radiologic profiles. Objective: The specific clinical correlates of PART are largely unknown; we aimed to identify cognitive and neuropsychological differences between PART, ADNC, and subjects with no tauopathy (NT). Methods: We compared 2,884 subjects with autopsy-confirmed intermediate-high stage ADNC to 208 subjects with definite PART (Braak stage I–IV, Thal phase 0, CERAD NP score “absent”) and 178 NT subjects from the National Alzheimer’s Coordinating Center dataset. Results: PART subjects were older than either ADNC or NT patients. The ADNC cohort had more frequent neuropathological comorbidities as well as APOE ɛ4 alleles than the PART or NT cohort, and less frequent APOE ɛ2 alleles than either group. Clinically, ADNC patients performed significantly worse than NT or PART subjects across cognitive measures, but PART subjects had selective deficits in measures of processing speed, executive function, and visuospatial function, although additional cognitive measures were further impaired in the presence of neuropathologic comorbidities. In isolated cases of PART with Braak stage III-IV, there are additional deficits in measures of language. Conclusion: Overall, these findings demonstrate underlying cognitive features specifically associated with PART, and reinforce the concept that PART is a distinct entity from ADNC.
CT quantitative analysis of pulmonary changes in rheumatoid arthritis
Authors: Pu Doudou , Yuan Hui , Ma Guangming , Duan Haifeng , Zhang Min , Yu Nan 
Published: February 2023

OBJECTIVE: To explore the application of quantitative computed tomography (CT) in analyses of lung changes in patients with rheumatoid arthritis (RA). METHODS: A total of 150 clinically diagnosed RA patients underwent chest CT and 150 matched non-smokers subjects with normal chest CT are enrolled. A CT software is applied to analyze CT obtained from both groups. The quantitative indices of emphysema are expressed as the percentage of lung area with attenuation < –950HU to the total lung volume (LAA–950%), and pulmonary fibrosis was expressed as the percentage of lung area with a attenuation of –200 to –700HU to the total lung volume (LAA–200––700%), quantitative indicators of pulmonary vascular include aortic diameter (AD), pulmonary artery diameter (PAD), the ratio of PAD to AD (PAD/AD ratio), the number of blood vessels (TNV), and the cross area of blood vessels (TAV). The receiver operating characteristic (ROC) curve is used to evaluate the ability of these indexes in identifying the changes in the lung in RA patients. RESULTS: Compared to the control group, the RA group has significantly lower TLV, larger AD, and smaller TNV and TAV (3921±1101 vs. 4490±1046, 33.26±4.20 vs. 32.95±3.76, 13.14±4.93 vs. 17.53±3.34, and 96.89±40.62 vs. 163.32±34.97, respectively, with all p < 0.001). Peripheral vascular indicator TAV has the better ability to identify lung changes in RA patients (area under ROC curve AUC = 0.894) than TNV (AUC = 0.780) or LAA–200 &sim–700% (AUC = 0.705). CONCLUSION: Quantitative CT can detect changes in lung density distribution and peripheral vascular injury in patients with RA and assess the severity.
EXPRESSION OF GENES INVOLVED IN P53 PATHWAY REGULATION IN NEUROBLASTOMA: A SHORT REVIEW
Authors: Inomistova M. , Klymniuk H. , Khranovska N. , Pavlyk S. , Shaida E. , Gorbach O. , Skachkova O. , Shymon D. 
Published: February 2023

The search for new prognostic and stratification genetic and epigenetic markers in neuroblastoma is an urgent problem in pediatric oncology. The review summarizes recent progress in studying the expression of genes involved in p53 pathway regulation in neuroblastoma. Several markers associated with recurrence risk and poor outcome are considered. Among them are MYCN amplification, high MDM2 and GSTP1 expression and homozygous mutant allele variant of GSTP1 gene A313G polymorphism. Prognostic criteria for neuroblastoma based on the analysis of miR-34a, miR-137, miR-380-5p, and miR-885-5p expression involved in regulating p53-mediated pathway are also considered. The authors’ research data on the role of the above markers in regulation of this pathway in neuroblastoma are presented. The study of alterations in expression of microRNAs and genes involved in p53 pathway regulation will not only expand our understanding of the mechanisms of neuroblastoma pathogenesis but could substantiate new approaches for delineating risk groups and risk stratification of neuroblastoma patients as well as treatment optimization based on the genetic characteristics of the tumor.
The translation technique analysis of assertive speech acts in Venom movie subtitles
Authors: Sagitasari Devy 
Published: February 2023

The objective of this study is to find out the translation techniques in assertive speech acts of Venom movie subtitles by professional and amateur translators. The researchers used the qualitative method in analyzing the selected assertive speech acts data which are taken from the script and classifying them according to Searle (1969) theory, then classify the translation techniques according to Molina and Albir (2002) theory. The findings showed there are 144 utterances (data) of assertive speech acts. The total of single assertive speech acts is 136 (0.9%) utterances, the total of couplet assertive speech acts is 7 (0.06%) utterances, the total of single translation technique by the professional translator is 36 (0.39%) utterances, the total of single translation techniques by the amateur translator is 65 (0.43%) utterances, the total of couplet translation technique by the professional translator is 62 (0.44%) utterances, the total of duplet translation technique by the amateur translator is 56 (0.41%) utterances, the total of triplet translation techniques by the professional translator is 23 (0.21%) utterances, the total of triplet translation techniques by the amateur translator is 19 (0.18%) utterances, the total of quadruplet translation techniques by the professional translator is 3 (0.03%) utterances, the total of quadruplet translation techniques by the amateur translator is 3 (0.03%) utterances. Hopefully, this research is helpful for the future researcher, especially those who deal with the translating skill
Keywords: Translation; Translation techniques; Assertive speech acts; Subtitle
Blended learning strategy for engineering students in EFL class: Adoption of varied ranges of delivery procedures
Authors: Wardhani Norita Prasetya 
Published: February 2023

COVID-19 Pandemic compels the teaching-learning strategy using remote learning to make the process of studying run well, including in Institut Teknologi Adhi Tama Surabaya, ITATS. A blended learning process could be applied to help the teaching-learning process. Before Covid-19 Pandemic spread in Surabaya, the students experienced fully face-to-face interaction in class. After COVID-19 existed in Surabaya, the students use the online learning process in the same semester. The highlight of this research is the case of the study which was related to the students in the teaching-learning process using blended learning in EFL class and explaining the ways how to teach and learn engineering students using blended learning. Descriptive quantitative was used to analyze the data. The data took from students' test and survey. Many students were getting difficulty in the implementation of blended learning using face-to-face strategy and google classroom. The students were allowed to access information from YouTube to make them easier to understand the materials. The lecturer was also explaining using google meet to have direct communication with the students was able to boost students’ knowledge of English materials. Adopting varied ranges of delivery procedures such as discussing was effectively boost the students' experiences and participation. Yet, those varied strategies are still ineffective rather than applying face-to-face class.
Keywords: Blended-learning; online learning: learning strategies
The achievement of students often taking selfies of the eleventh-grade students at SMKS Perwari Tulungagung
Authors: Nugrahini Yulia 
Published: February 2023

In this study, the researcher wanted to prove whether the students who often take selfies get lower achievement than the students who do not often take a selfie at SMKS Perwari Tulungagung in the 2020/2021 academic year. The researcher used an ex-post-facto experimental design that was categorized into quantitative research. This study was conducted at SMKS Perwari Tulungagung. The population of this study was all students of eleventh grade at SMKS Perwari Tulungagung in the 2020/2021 academic year which consist of 320 students and the sample was taken randomly 15% about 48 students. The finding of this study can be seen that the average score of the experimental group was 84 and the control group was 85. It means that the experimental group got a lower score than the control group. Then, after the researcher analyzed the data by using the t-test formula, the researcher got the result t count was 2.557 by a significant level of 0.05 and df= n-2 = 48-2=46, and the t table is 2.013. Finally, it proved that the students who often took selfies got lower achievements than the students who did not often take a selfie on the students' achievement at SMKS Perwari Tulungagung in the 2020/2021 academic year.
Key Words: Taking selfies; achievements;
Síndrome de Rett, una mirada actual
Authors: Arancibia Trinidad , Pardo Rosa , Barrientos Paulo 
Published: February 2023

El síndrome de Rett (SR) es un trastorno del neurodesarrollo poco frecuente descrito en 1966. Se caracteriza por un estancamiento y posterior regresión del desarrollo psicomotor, asociado a la aparición de movimientos estereotipados de manos, después de un período de desarrollo aparentemente normal. Se han identificado variantes patogénicas del gen MECP2 en la mayoría de los casos. Esta revisión narrativa se enfoca en analizar información actualizada respecto al SR, tanto en sus aspectos médicos como sociales de forma global, con un énfasis en la situación chilena. Se procedió a una búsqueda de información actualizada en SR en múltiples bases de datos, seleccionando 68 artículos publicados entre 1995 y 2022, 56 sobre aspectos médicos, 11 sobre aspectos sociales y 1 en ambos. Adicionalmente, se incluyó información de páginas gubernamentales en los aspectos sociales. Dentro de los aspectos médicos se abordan clínica, diagnóstico y clasificación, genética, fisiopatología y manejo. Respecto a lo social, se enfoca en el estrés psicoemocional que puede causar en la familia en base a estudios internacionales y por último, en las distintas herramientas con las que cuentan las pacientes chilenas. El SR es una patología compleja que afecta múltiples sistemas, requiriendo un manejo multidisciplinario y teniendo un importante impacto psicológico y socioeconómico en la familia. En Chile, las leyes 20.422 y 21.292, el Servicio Nacional de Discapacidad y la creación de la fundación “Caminamos por Ellas y Ellos” son avances positivos en el apoyo a estas pacientes y sus familias.
Manipulación abdominal y otros factores de riesgo culturales asociados a complicación de apendicitis aguda en pacientes pediátricos
Authors: Aguilar-Andino David , Licona Rivera Tania Soledad , Osejo Quan Jorge Alberto , Carranza Linares Ricardo Jafet , Molina Soto Marco Antonio , Alas-Pineda César 
Published: February 2023

La apendicitis aguda (AA) en niños usualmente es confundida con empacho, enfermedad que, según creencia popular, se produce por ingesta de alimentos mal cocidos o fríos causando síntomas gastrointestinales. El tratamiento empírico es la manipulación abdominal, que consiste en masaje con distintas maniobras sobre la pared abdominal, acompañado de remedios caseros. Se desconoce el efecto de dichas terapias en la evolución de AA. Objetivo: Determinar la asociación entre manipulación abdominal y AA complicada en pacientes pediátricos. Pacientes y Método: Estudio de casos y controles en menores de 18 años, con cuadro de abdomen agudo, intervenidos quirúrgicamente por AA, en un centro hospitalario de Honduras. Se definió como casos los pacientes con AA complicada y controles aquellos con AA simple. Se empleó un modelo regresión logística binaria para determinar los factores de riesgo asociados a complicaciones de AA. Resultados: Se enrolaron 31 casos y 31 controles, mediana de edad 11 años. El 58,1% procedía de una zona urbana. El 77,4% de los casos y 9,7% de los controles tuvo antecedente de manipulación abdominal. El síntoma inicial más frecuente fue dolor abdominal. En análisis univariado el sexo masculino, tiempo de evolución prolongado, uso de remedios caseros, leucocitosis > 20,000/mm3 y manipulación abdominal fueron factores de riesgo para AA complicada. En modelo multivariado, la manipulación abdominal fue el principal factor de riesgo (OR 15,94 [3,40-74,59]). Conclusión: Creencias culturales como el empacho y sus respectivos tratamientos como la manipulación abdominal y los remedios caseros, son factores de riesgo para la complicación de un cuadro instaurado de AA, así mismo contribuyen al retraso diagnóstico.
Desempeño cognitivo en preescolares con Hipotiroidismo Congénito incorporados en un programa de seguimiento
Authors: Ontiveros M. Esperanza , González M. Juan A , Rivera G. Rolando , Sánchez P. Carmen , Barragán M. Gerardo 
Published: February 2023

La edad de inicio del tratamiento es determinante para la evolución y limitación de las secuelas neu- rológicas del Hipotiroidismo Congénito (HC). Incorporar los niños a programas de seguimiento podría ser de gran ayuda.Objetivo: Evaluar el desempeño cognitivo en preescolares con HC incorpo- rados a un programa de seguimiento. Pacientes y Método: Estudio prospectivo de 93 pacientes con diagnóstico confirmado de HC. Se evaluó el Cociente Intelectual (CI) mediante Escala de Inteligencia de Wechsler para preescolar y primaria (WPPSI) a los 4 y 5 años y WISC-R a los 6 años de edad. Se analizaron las puntuaciones de Escala Global (CIG), Verbal (CIV) y Ejecución (CIE). Resultados: La muestra de estudio fue de 80 niños. La edad promedio de inicio del tratamiento hormonal fue de 42 ± 18 días, el tratamiento inició en forma temprana en 25 pacientes (24 ± 6 días) y tardía en 55 (50 ± 16 días). La dosis promedio inicial de Levotiroxina fue de 13,5 ± 1,5 μg/kg/día; los pacientes con atirosis e inicio tardío obtuvieron puntajes más bajos en la escala verbal (85 ± 14), ejecución (89 ± 12) y global (86 ± 13) a los 4 años de edad, comparados con pacientes con inicio temprano, quienes tuvieron puntaje dentro del punto de corte para la clasificación de CI normal (90-109 pun- tos). La comparación los 6 años de edad revela diferencias de hasta 14 puntos en el CI para la escala de ejecución y de 11 puntos en la escala global entre los niños con atirosis e inicio temprano, con y sin asistencia regular al programa de seguimiento. Discusión: Estos resultados respaldan la importancia del inicio temprano del tratamiento y la incorporación de los niños a programas de seguimiento y es- timulación temprana. El tipo de hipotiroidismo y la edad de inicio del tratamiento fueron los factores más significativos que afectaron el desempeño cognitivo.
Kesejahteraan Spiritual Mempengaruhi Kelekatan Ibu dan Janin pada Ibu Hamil
Authors: Wahyusari Shinta , Mariani Mariani 
Published: February 2023

Abstrak
Transisi menjadi orang tua merupakan masa kritis bagi pasangan yang telah menikah dan memiliki anak. Selama periode pencapaian peran menjadi orang tua, proses pembentukan kelekatan ibu dan janin sangat penting untuk dilakukan dan kesejahteraan spiritual merupakan faktor penting bagi ibu hamil untuk dapat beradaptasi dengan kondisinya selama hamil. Penelitian ini bertujuan untuk mengetahui hubungan kesejahteraan spiritual dengan kelekatan ibu dan janin pada ibu hamil. Metode penelitian yang digunakan adalah analitik korelasi dengan menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah semua ibu hamil di wilayah kerja Puskesmas Wangkal Kabupaten Probolinggo. Teknik sampling yang digunakan adalah total sampling. Jumlah sampel sebesar 77 responden. Teknik pengumpulan data menggunakan kuesioner SWBS dan PAI untuk mengukur kesejahteraan spiritual dan kelekatan ibu dan janin. Data dianalisis menggunakan Pearson. Hasil penelitian didapatkan rata-rata skor religious well being (51,81), existential well being (51,18), total skor kesejahteraan spiritual (102,99) serta kelekatan ibu dan janin (58,96). Hasil analisis menunjukkan bahwa ada hubungan yang signifikan antara kesejahteraan spiritual dengan kelekatan ibu dan janin (ρ: 0,000). Dari hasil penelitian ini menunjukkan bahwa pentingnya meningkatkan kesejahteraan spiritual selama periode kehamilan sehingga dapat meningkatkan kelekatan ibu dan janin.
Kata kunci: kesejahteraan spiritual, kesejahteraan eksistensial, kelekatan ibu dan janin

Abstract
The transition to parenthood is a critical time for married couples and their children. The process of forming the attachment of the mother and fetus is very important during this period, and spiritual well-being is an important factor for pregnant women to be able to adapt to their conditions during pregnancy. This study aimed to determine the relationship between spiritual well-being and prenatal attachment in pregnant women. This research used analytic correlation using a cross sectional approach. The population were all pregnant women in the working area of the Wangkal Health Center, Probolinggo. This study included 77 respondents chosen through random sampling. To assess spiritual well-being and prenatal attachment, SWBS and PAI questionnaires were used to collect data. The data was analyzed with Pearson. The results of the study obtained an average score of religious well-being (51,81), existential well-being (51,18), a total score of spiritual well-being (102.99), and prenatal attachment (58.96). The analysis results revealed a significant relationship between spiritual well-being and the attachment of the mother and fetus (: 0.000). These findings suggest that it is critical to improve spiritual well-being during pregnancy in order to increase prenatal attachment.
Keywords: spiritual well being, existential well being, prenatal attachment