bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community Outreach Initiatives in Dermatology - Cross-sectional Study
Authors: Fritsche Madelaine , Maglakelidze Natella Natella , Zaenglein Andrea , Lam Charlene 
Published: January 2023

Abstract
Disparities in health care coverage, chronic diseases, mental health, and mortality among racial and ethnic groups, incarcerated individuals, and low-income communities are prevalent in the United States (U.S.). There is a need to address these shortfalls in access to care. Community outreach efforts can help reduce these disparities and bridge access to adequate healthcare to meet patient needs. In dermatology, there is a lack of studies assessing community outreach initiatives and whether these initiatives address diverse community needs. This cross-sectional study was designed to identify and categorize community outreach initiatives offered by academic dermatology programs in the U.S. to recognize potential areas of improvement to better serve our communities. We surveyed 142 ACGME-accredited U.S. dermatology programs regarding their community outreach initiatives and obtained information for 68% of the programs. Most dermatology residency programs provided traditionally popular community outreach initiatives like skin cancer screenings and free general dermatology clinics. Conversely, very few programs offered initiatives addressing the needs of patients of color, minoritized communities such as American Indians, or chronic skin disease patients. These may be opportunities to broaden our definition of community outreach and address the dermatological needs of all communities.
Reduced hepatocyte mitophagy is an early feature of NAFLD pathogenesis and hastens the onset of steatosis, inflammation and fibrosis
Authors: Undamatla Ramya , Fagunloye Olayemi G. , Chen Jeffrey , Edmunds Lia R. , Murali Anjana , Mills Amanda , Xie Bingxian , Pangburn Martha M. , Sipula Ian , Gibson Gregory , Croix Claudette St. , Jurczak Michael J. 
Published: January 2023

Abstract
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies that includes steatosis, steatohepatitis (NASH) and fibrosis and is strongly associated with insulin resistance and type 2 diabetes. Changes in mitochondrial function are implicated in the pathogenesis of NAFLD, particularly in the transition from steatosis to NASH. Mitophagy is a mitochondrial quality control mechanism that allows for the selective removal of damaged mitochondria from the cell via the autophagy pathway. While past work demonstrated a negative association between liver fat content and rates of mitophagy, when changes in mitophagy occur during the pathogenesis of NAFLD and whether such changes contribute to the primary endpoints associated with the disease are currently poorly defined. We therefore undertook the studies described here to establish when alterations in mitophagy occur during the pathogenesis of NAFLD, as well as to determine the effects of genetic inhibition of mitophagy via conditional deletion of a key mitophagy regulator, PARKIN, on the development of steatosis, insulin resistance, inflammation and fibrosis. We find that loss of mitophagy occurs early in the pathogenesis of NAFLD and that loss of PARKIN hastens the onset but not severity of key NAFLD disease features. These observations suggest that loss of mitochondrial quality control in response to nutritional stress may contribute to mitochondrial dysfunction and the pathogenesis of NAFLD.
Value of proteinuria in evaluating the severity of HELLP and its maternal and neonatal outcomes
Authors: Jiao Yan , Song Zimeng , Li Hongyuan , Wang Shiliang , Zhang Jiao , Li Jian , Liu Jia , Wang Peng , Chen Yanhong 
Published: January 2023

Abstract
Background: HELLP syndrome refers to a group of clinical syndromes characterized by hemolysis, elevated liver enzymes and low platelet, and the evidence on the association between proteinuria and the severity of HELLP and its maternal and neonatal outcomes is rare.
Methods: 106 pregnant women were assigned to the proteinuric group (24-hUPro ≥0.3 g, 79 cases) and the non-proteinuric group (24-hUPro<0.3 g, 27 cases). The proteinuric group was further divided into three subgroups: mild group (24-hUPro:0.3-2.0g, 33 cases), moderate group (24-hUPro:2.0-5.0g, 21 cases) and severe group (24-hUPro: ≥5.0 g, 25 cases). The general clinical data, laboratory indexes, complications and pregnancy outcome and adverse neonatal outcomes of HELLP with or without proteinuric were analyzed.
Results: Compared with proteinuricgroup, the non-albuminuric group or in the three proteinuric subgroups of HELLP pregnant women's , increased proteinuria was associated with earlier onset gestations, higher incidence of abdominal pain, skin jaundice, headache, blurred vision (p < 0.05 respectively), and also the higher levels of ALT, AST, LDH, Fib, APTT, ATⅢ, proportions of tubular urine and lower levels of ALB, PLT (p< 0.05 respectively). In the three subgroups of the proteinuric group, the ratio of fetal growth restriction, cesarean section and postpartum hemorrhage were compared, and the difference was statistically significant (p < 0.05 respectively). Compared with the proteinuric group, the non-proteinuric group had higher birth weight, birth length, and lower SGA, admission rate in NICU (p < 0.05 respectively). In the three subgroups of the proteinuric group, significant differences were identified in the adverse outcomes of newborns (p < 0.05 respectively), and the incidence of adverse outcomes in neonates tended to be higher. Significant differences were identified in birth weight, birth length, and lower SGA and NICU occupancy rate among the three subgroups (p < 0.05 respectively).
Conclusions: HELLP syndrome is a severe complication of pregnancy, involving multiple systems of the whole body. It has posed a great challenge to obstetricians for its acute onset, dangerous condition, rapid progress, and great harm. Thus, insights into HELLP syndrome should be gained, and early diagnosis, early treatment and timely termination of pregnancy should be conducted to reduce the incidence of maternal and fetal adverse outcomes and improve maternal and fetal prognosis.
Firefly algorithm hybridized with genetic algorithm for multi-objective integrated process planning and scheduling
Authors: Ri Kwang-Won , Mun Kyong-Ho 
Published: January 2023

Abstract
The multi-objective integrated process planning and scheduling (MOIPPS) problem has huge search space and complex technical constraints.Therefore, there is considerable difficulty in obtaining efficient solutions, and hence, metaheuristic-based solution algorithms have been actively introduced. In our paper, we proposed a method to obtain a set of Pareto solutions using firefly algorithm hybridized with genetic algorithm for the MOIPPS problem.we considered a MOIPPS problem model that simultaneously optimizes the makespace, total flow time and total tardiness, maximum machine workload and total machine workload.Three different scale instances have been employed to evaluate the performance of the proposed algorithm. The results show that the proposed algorithm has excellent performance in solving the MOIPPS problem.
Transitioning to Adult Mental Health Services for young people with ADHD: an Italian-based Survey on practices for Pediatric and Adult Services
Authors: Roberti Elisa , Scarpellini Francesca , Campi Rita , Giardino Michele , Clavenna Antonio , Bonati Maurizio 
Published: January 2023

Abstract
The present study assessed the transitioning process of Attention-Deficit/Hyperactivity Disorder (ADHD) patients in Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Italian territory. We asked child and adult psychiatrists to report the current state of services and their observations on limitations and possible future matters that need to be addressed. Seventy-seven centers (42 CAMHS, 35 AMHS) filled in a web-based survey in which they reported the number of ADHD patients, how many transitioning patients they had within the past year, and how they structured transition. A fragmented picture emerged from the survey. Lack of resources, training, and communication between services hinder the transition process, and many adult patients remain under CAMHS' care. While some services have a protocol, there is no structured guidance that can help improve integration and continuity of treatment. The observed situation reflects a need for improvement and for standard guidelines to enable a successful transition process, considering both clinicians' and patients' necessities.
Stem cell pathways and Notch signaling an emerging role in the development of acquired Drug Resistance in Neuroblastoma
Authors: Corrigal John Clark- , Zaka Masood , Myssina Svetlana , Michaelis Martin , Cinatl Jindrich , Ahmed Shafiq , Carr-Wilkinson Jane 
Published: January 2023

Abstract
Purpose: Neuroblastoma is a paediatric tumour that develops from embryonal neural crest cells that give rise to the sympathetic nervous system. Aggressive high-risk disease remains a clinical challenge and despite multi-modal therapy, survival rates are poor. Most neuroblastomas initially respond well to induction chemotherapy however, 50-60% of patients with high-risk disease will relapse with aggressive disease. A major obstacle in the successful treatment of this disease is the development of acquired resistance to chemotherapeutic agents. We hypothesize that aggressive neuroblastomas acquire a more immature phenotype in addition to increased expression of genes linked to stem cell pathways.
Methods: In this study we investigated the role of stem cell related genes in the development of acquired drug resistance using Q- Real Time PCR and bioinformatics analysis on three-paired vincristine sensitive and resistant cell lines.
Results: The study outlines 11 differentially expressed genes with several targets involved primarily in notch signalling, and stem cell development.
Conclusions: The findings implicated in this study, which include comparative analysis against patient microarray data, warrants further study on the functional effects of these genes/pathways to elucidate their role in acquired drug resistance.
Application of tree based enhanced stacking ensemble learning
Authors: Xu XiaoFei , Wu Yonghong 
Published: January 2023

Abstract
Since it is difficult for machine learning algorithms, such as XGBoost, LightGBM, to extract feature interaction effectively and deep learning algorithms have high time complexity, a tree enhanced stacking integrated model is proposed in this paper, based on tree model feature generation theory and convolutional neural network(CNN) feature extraction theory. Firstly, to effectively extract feature interaction, tree-based-enhanced-stacking generates new features through tree model LightGBM and merges them with the original features. Secondly, to enhance the presentation ability, LightGBM is modified into ML LightGBM with hierarchical structure. Finally, ML_LightGBM, XGBoost, Random Forest and other models are introduced into the stacking integration framework to generate secondary data sets. To enhance the deep feature extraction ability of tree-based-enhanced-stacking, CNN model is used to extract features from the secondary data sets. Compared with ML_LightGBM, XGBoost, Random Forest in two data sets ppdai and default, the results show that the tree enhanced stacking model proposed in this paper has significantly improved in AUC, ACC, KS, loss and other indicators.
Bioleaching of rare earth elements from phosphogypsum by Aspergillus niger
Authors: Zhang Jiangang , Zhang Xinyue , Su Xiangdong , Du Haijun , Lu Yongzhong 
Published: January 2023

Abstract
Phosphogypsum (PG) is a solid waste product of the phosphoric acid industry. As it contains various rare earth elements (REEs), it is considered an important source of REEs. In this paper, direct and indirect contact methods were used to extract rare earth elements from PG by Aspergillus Niger(A. niger). the contents of REEs in the original PG sample and the leaching solution were analyzed by an inductively coupled plasma mass spectrometer (ICP-MS). Using scanning electron microscopy (SEM), the morphology of A. niger cells was analyzed before and after leaching. At optimal conditions (Temperature 30℃, oscillation speed of 150 rpm, and solid-liquid ratio of 2:1), the REE leaching rate was 74%; the dominant elements were Y, La, Ce, and Nd. It was found that A. niger and its metabolites organic acids played a decisive role in the leaching process. Compared with inorganic acid leaching of REEs from PG, using A. niger is an environmentally friendly approach with potential in the large-scale industry.
Balanced appetite regulation of Shu-mu acupoint catgut embedding in abdominal obesity: secondary analysis of a randomized clinical trial
Authors: Zhang Xinghe , Li Qifu , Huang Gaoyangzi , Pei Xianmei , Tang Xin , Zhang Renrui , Yi Rong , Li Li , Xing Chonghui , Zhao Siwen , Guo Taipin , Liang Fanrong 
Published: January 2023

Abstract
Objective

To explore the effect of Shu-mu acupoint catgut embedding (ACE) on appetite in abdominal obesity (AO) patients.

Methods

This is a secondary analysis of a multicenter, double-blind, randomized controlled trial. Which was conducted in China between July 2018 and June 2022. Eighty AO participants who received Shu-mu ACE intervention were divided into moderate appetite (MA) and strong appetite (SA) subgroups, according to the appetite at baseline. While 79 AO participants who received NACE intervention were also divided into MA and SA subgroups. All participants were given a 12-week actual intervention period and a 4-week follow-up. Appetite was assessed at baseline and after 6, 12 and 16 weeks.

Results

71 participants who received Shu-mu ACE and 74 participants who received NACE were included in the final analysis. After the Shu-mu ACE, at 16 weeks, the appetite of the SA subgroup decreased to the same level as the MA subgroup (p > 0.05). All 36 AO participants’ appetite had decreased in the SA subgroup. While in the MA subgroup, 22 AO participants had a decrease in appetite, 7 increased, 4 had no change, and 2 had appetite data missing. During the NACE intervention and follow-up, the appetite of the SA subgroup was always higher than the MA subgroup (p < 0.01). In the SA subgroup, 32 decreased, 4 increased, 5 had no change, and 2 appetite data missing. While in the MA subgroup, 14 decreased, 7 increased, and 10 had no change.

Conclusions

Catgut embedding at Shu-mu acupoint could regulate the appetite of AO to the normal level, rather than dramatically inhibit the appetite.
Trial registration This study was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR1800016947). 4 July 2018; https://www.chictr.org.cn/showproj.aspx?proj=28782
Standardized CT Value: A Promising Diagnostic Parameter to Differentiate Lipid and Fibrous Coronary Plaques
Authors: Gao Yaqi , Pan Yao , Jia Chongfu , Wu Wei , Wang Zhaoqian , Zhang Yuepeng , Wang Hao , Hui Hui 
Published: January 2023

Abstract
Purpose
To evaluate the accuracy of the standardized CT value in differentiating between lipid-rich and fibrous coronary plaques and to examine the stability of its cutoff preliminarily.
Methods
Patients who underwent both coronary computed tomographic angiography (CCTA) and intravascular ultrasound (IVUS) were included. The CT values of the plaque assessed from all, four, and two short-axis slices were acquired. We defined the standardized CT value as the Hounsfield unit (HU) ratio of the plaque to the ascending aorta. The nature of the plaques was determined by IVUS. The receiver operating characteristic curve was applied to determine the diagnostic performance of the standardized and traditional CT values.
Results
A total of 60 patients with 74 plaques were included. 35 lipid-rich plaques and 39 fibrous plaques were diagnosed by IVUS. The CT value of the aorta showed a strong correlation with plaques (r = 0.420, P < 0.01). The threshold CT values differentiating the plaque types on all-slice, four-slice, and two-slice were 55 HU, 48 HU, and 52 HU, and the threshold of the standardized CT value was consistently 0.149. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the four-slice CT values differentiating lipid and fibrous plaques were 69%, 87%, 83%, 76% and the corresponding standardized CT values were 91%, 82%, 82% and 91%.
Conclusions
Compared with traditional CT values, standardized CT values can significantly improve the sensitivity and NPV for differentiating between lipid-rich and fibrous coronary plaques while achieving moderate to high specificity and PPV. Furthermore, the cutoff is stable.
Effective clearance of rituximab-resistant tumor cells by breaking the mirror-symmetry of Immunoglobulin G and simultaneous binding to CD55 and CD20
Authors: Lee Sang Min , Min Sung-Won , Kwon Hyeong Sun , Bae Gong-Deuk , Jung Ji Hae , Park Hye In , Lee Seung Hyeon , Lim Chung Su , Ko Byoung Joon , Lee Ji Chul , Jung Sang Taek 
Published: January 2023

Abstract
Complement dependent cytotoxicity (CDC), which removes aberrant target cells through the assembly and complex formation of serum complement molecules, is the main effector function of anticancer therapeutic antibodies. In this study, we found that the CDC activity of anti-CD20 antibody increased remarkably when the symmetry of natural Immunoglobulin G (IgG) antibodies was broken. In addition, the expression of CD55 (a checkpoint inhibitor in the CDC cascade) was significantly increased in an in-house constructed rituximab-resistant cell line, suggesting that CD55 overexpression might be a mechanism by which cancer cells acquire rituximab resistance. Based on these findings, we developed an asymmetric bispecific antibody (SBU-CD55×CD20) that targets both CD55 and CD20 simultaneously to effectively remove rituximab-resistant cancer cells. In various cancer cell lines, including rituximab-resistant lymphoma cells, the SBU-CD55×CD20 antibody exhibited significantly higher CDC activity than either anti-CD20 IgG antibody alone or a combination of anti-CD20 IgG antibody and anti-CD55 IgG antibody. Furthermore, compared with other bispecific antibodies with symmetric features, the asymmetric bispecific antibody (SBU-CD55×CD20) exhibited significantly higher CDC activity against rituximab-resistant cancer cells. These results demonstrate that improving CDC using an asymmetric CD55-binding bispecific antibody could be a new strategy for designing therapeutics to treat patients with relapsed or refractory cancers.
Labelling Matrix Metalloproteinases
Authors: Zhang Run-Fu , Zhang Bing , Chang-Jiang Wang , Jin Jing-Yi 
Published: January 2023

Abstract:
Matrix metalloproteinases (MMPs) are a family of zinc-containing proteases
that participate in many physiological and pathological processes in vivo. Recently, the
MMP network has been established according to a deeper understanding of its functions.
Some MMPs have been also regarded as biomarkers of various diseases, including inflammation,
nerve diseases, and cancers. MMP labelling has been thus paid more attention
in recent decades. Accordingly, both reagents and technologies for MMP labelling
have been rapidly developed. Here we summarize the recent development of some MMP
labelling methods. This review was identified through keyword (MMPs; labelling; etc.)
searches in the ScienceDirect database, Scifinder, Web of Science, and PubMed for
which typical cases were used for an inductive overview. In spite of the advances in
MMP labelling, selective labelling of a specific MMP is still an open issue. We hope that
this article can be helpful in developing specific MMP labelling methods in future.
Age-Related Alterations in Mesenchymal Stem Cell Function: Understanding
Mechanisms and Seeking Opportunities to Bypass the Cellular Aging
Authors: Rasouli Mehdi , Naeimzadeh Yasaman , Hashemi Nader , Hosseinzadeh Simzar 
Published: January 2023

Abstract:
Undoubtedly, mesenchymal stem cells (MSCs) are the most common cell therapy candidates in
clinical research and therapy. They not only exert considerable therapeutic effects to alleviate inflammation
and promote regeneration, but also show low-immunogenicity properties, which ensure their safety
following allogeneic transplantation. Thanks to the necessity of providing a sufficient number of MSCs to
achieve clinically efficient outcomes, prolonged in vitro cultivation is indisputable. However, either following
long-term in vitro expansion or aging in elderly individuals, MSCs face cellular senescence. Senescent
MSCs undergo an impairment in their function and therapeutic capacities and secrete degenerative
factors which negatively affect young MSCs. To this end, designing novel investigations to further
elucidate cellular senescence and to pave the way toward finding new strategies to reverse senescence is
highly demanded. In this review, we will concisely discuss current progress on the detailed mechanisms
of MSC senescence and various inflicted changes following aging in MSC. We will also shed light on the
examined strategies underlying monitoring and reversing senescence in MSCs to bypass the comprised
therapeutic efficacy of the senescent MSCs.
The Impact of COVID-19 Lockdown on Patients with Type 2 Diabetes
Mellitus: A Brief Report
Authors: Vozza Alfredo , Porfido Erasmo , Delvino Alessandra , Custodero Carlo , Lisco Giuseppe , Triggiani Vincenzo , Tortorella Cosimo , Piazzolla Giuseppina 
Published: January 2023

Background:
The Italian population’s habits changed dramatically during the “COVID-
19 lockdown” due to physical distancing and self-isolation. Moreover, medical consultations of
patients with chronic diseases, such as type 2 diabetes (T2D), were suspended or postponed, unless
urgent or semi-urgent, for several consecutive months. Thus, it is expected that the lockdown could
have affected glucometabolic control in T2D.

Purpose:
The aim of the study was to assess changes in glucometabolic control in a cohort of T2D
patients before (T1) and after (T2) the COVID-19 lockdown (March-May 2020).

Methods:
The study was approved by the Ethics Committee of the University of Bari, and all patients
provided informed written consent to participate. Medical history, complete physical examination,
and laboratory assessment were conducted as real-life clinical practice. Changes in clinical
and laboratory variables between T1 and T2 were calculated.

Results:
In detail, 13 patients were on metformin as monotherapy, 36 on GLP-1RA, 12 on sodiumglucose
transporter 2 inhibitors (SGLT-2i), and 2 on dipeptidyl-peptidase 4 inhibitors (DPP4i). The
mean age was 65.3 years (43-83). Study participants were mainly men (73%). The body weight
(BW) ranged from 56 to 145 kg, and the waist circumference ranged from 88 to 146 cm. The mean
HbA1c was 51.0 mmol/mol. At T2, no statistically significant changes were observed from baseline
except for BW [-1.6 (-2.60 to -0.62)] and HbA1c [-2.90 (-4.69; -1.12)].

Conclusion:
We evaluated the effects of the COVID-19 lockdown on glucometabolic control in
patients with background well-controlled T2D. We found that the lockdown had no adverse effects
on metabolic profile regardless of background clinical characteristics and antihyperglycemic management.
Despite limitations due to the nature of this study (sample size, retrospective observation,
lack of data on lifestyle changes in our patients' everyday lives), T2D patients managed in our
Diabetes Centers faced the lockdown-related restrictions without any detrimental consequence.