bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of blood oxygenation level-dependent magnetic resonance imaging in early evaluation of the response and prognosis of esophageal squamous cell carcinoma treated with definitive chemoradiotherapy: A preliminary study
Authors: Zheng Huanhuan , Zhang Hailong , Zhu Yan , Wei Xiaolei , Liu Song , Ren Wei 
Published: February 2023

Abstract
Background
To establish a quantitative imaging predictor for evaluation of early treatment response and prognosis to definitive chemoradiotherapy (dCRT) in patients with esophageal squamous cell carcinoma (ESCC), using blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI).
Methods
The R2* values were obtained pre and 2–3 weeks post-dCRT in 28 patients with EC using BOLD MRI. Independent samples t-test (normality) or Mann-Whitney U test (non-normality) was used to compare the differences of R2*-related parameters between the complete response (CR) and the non-CR groups. Diagnostic performance of parameters in predicting response was tested with receiver operating characteristic (ROC) curve analysis. The 3-year overall survival (OS) was evaluated using Kaplan Meier curve, log rank test, and Cox proportional hazards regression analysis.
Results
The post-R2*, ∆R2*, and ∆%R2* in the CR group were significantly higher than those in the non-CR group (P = 0.002, 0.003, and 0.006, respectively). The R2*-related parameters showed good prediction of tumor response, with AUC ranging from 0.813 to 0.872. The 3-year OS rate in patients with ∆R2* >-7.54 s− 1 or CR were significantly longer than those with ∆R2* ≤ -7.54 s− 1 (72.37% vs. 0.00%; Hazard ratio, HR = 0.196; 95% confidence interval, 95% CI = 0.047–0.807; P = 0.024) or non-CR (76.47% vs. 29.27%; HR = 0.238, 95% CI = 0.059–0.963; P = 0.044).
Conclusions
The preliminary results demonstrated that the R2* value might be a useful hypoxia imaging predictor for response and prognosis of ESCC treated with dCRT. BOLD MRI may be used as a potential tool for evaluating tumor oxygenation metabolism, which is routinely applied in clinical practice and beneficial to clinical decision-making.
Content comparison of the EORTC CAT-Core, SF-36, FACT-G, and PROMIS role and social functioning measures based on the International Classification of Functioning, Disability and Health
Authors: Pilz Micha J. , Rothmund Maria , Lidington Emma , Piccinin Claire , Arraras Juan I. , Groenvold Mogens , Holzner Bernhard , Leeuwen Marieke , Petersen Morten Aa. , Schmidt Heike , Young Teresa , Giesinger Johannes M. 
Published: February 2023

Abstract
Objectives
In line with the World Health Organizations’ health definition, patient-reported outcome (PRO) measures frequently cover aspects of social health. Our study aimed to evaluate the role functioning (RF) and social functioning (SF) contents assessed by PRO measures frequently used in cancer patients.
Methods
We analysed the item content of the SF and RF domains of the EORTC CAT Core, the EORTC QLQ-C30, the SF-36, and the FACT-G as well as the PROMIS item bank covering the Ability to Participate in Social Roles and Activities. Following an established methodology we linked item content to the International Classification of Functioning, Disability and Health (ICF) framework.
Results
The content of 85 items was assigned to three ICF components (‘Activities and Participation’, ‘Body Functions’, and ‘Environmental Factors’). The EORTC CAT Core RF items were mostly related to the first-level ICF categories 'Domestic life' and 'Community, social and civic life', while its SF item bank focused on 'Interpersonal interactions and relationships'. These three categories were also covered by the PROMIS social participation item bank. The FACT-G Social/Family scale focused on environmental factors ('Support and Relationships' and 'Attitudes') while the SF-36 Role-physical/emotional scales had a stronger focus on 'General tasks and demands' and 'Major life areas'.
Conclusions
Our results highlight conceptual overlap and differences among PRO measures for the assessment of social health in cancer. This information may help to select the most appropriate measure for a specific setting or study purpose and to better understand the possibilities of linking scores across different PRO measures.
Cultivation and visualization of a methanogen of the phylum Thermoproteota
Authors: Hatzenpichler Roland , Kohtz Anthony , Krukenberg Viola , Petrosian Nickolai , Jay Zackary , Pilhofer Martin 
Published: February 2023

Abstract

Methane is the second most abundant climate-active gas and understanding its sources and sinks is a crucial endeavor in microbiology, biogeochemistry, and climate sciences (1,2). For decades, it was thought that methanogenesis, the ability to conserve energy coupled to methane production, was restricted to a taxonomically and metabolically specialized group of archaea, the Euryarchaeota1. The discovery of marker genes for anaerobic alkane cycling in metagenome-assembled genomes obtained from diverse habitats has led to the hypothesis that archaeal lineages outside the Euryarchaeota are involved in methanogenesis (3-6). Here, we cultured Candidatus Methanosuratincola yellowstonensis, a member of the archaeal phylum Thermoproteota, from a terrestrial hot spring. Growth experiments combined with activity assays, stable isotope tracing, and genomic analyses confirmed that this thermophilic archaeon grows via methyl-reducing hydrogenotrophic methanogenesis. Cryo-electron tomography revealed that Ca. M. yellowstonensis cells are archaellated coccoid cells that form intercellular bridges, providing two to three cells with a continuous cytoplasm and S-layer. The wide environmental distribution of Ca. M. yellowstonensis suggests that they might play important and hitherto overlooked roles in carbon cycling within diverse anoxic habitats.
Combined intervention of multiple methods to alleviate preoperative anxiety in preschool children undergoing strabismus surgery: a randomized controlled study
Authors: Jin Yuexi , Ye Yingchao , Chen Zhangyan , Wu Wenxin , Jiang Wanna , Jin Zhousheng , Liu Le , Wu Yiquan 
Published: February 2023

Abstract
Background
Preoperative anxiety caused by strabismus surgery has an unpleasant and disturbing feeling for both children and their parents. Preoperative anxiety in children is associated with an adverse postoperative outcome. This study aimed to evaluate the effect, feasibility, and influence on postoperative behavior of three intervention programs in reducing preoperative anxiety in preschool children undergoing strabismus surgery.
Methods
300 children scheduled for elective monocular strabismus correction were divided into 3 groups (n = 100 for each) by random number table method. Children in Group M received 0.1 mg/kg midazolam intravenously in the waiting room. Children in Group C watched cartoons selected by themselves in the waiting room and operating room until five minutes before the induction of anesthesia. Children in Group CM received 0.05 mg/kg midazolam intravenously in the waiting room and watched the selected cartoons continuously in the waiting room and operating room. Children’s preoperative anxiety was determined by the modified Yale Preoperative Anxiety Scale (mYPAS) at different time points. Cooperative scores during the anesthesia induction period, recovery time, emergence agitation during the recovery period and the postoperative adverse behaviors were recorded.
Result
The mYPAS scores of group CM in the waiting room and before anesthesia induction were lower than those of group C and group M (P < 0.05). The incidence of agitation and adverse behavior in the group CM were lower than group C and group M (P < 0.05). The induction compliance checklist (ICC) scores of group CM and group M were lower than those of group C (P < 0.05). Group M’s recovery time was prolonged (P < 0.05). The anxiety levels in the waiting room and before anesthesia induction were positively correlated with the agitation during the recovery period, and the behavioral changes at 1 week and 1 month after the surgery.
Conclusion
Combining low-dose midazolam with cartoon watching in the waiting area and operating room can safely and effectively minimize preoperative anxiety in preschoolers having strabismus surgery. It was also successful in lowering emergence agitation and postoperative unfavorable behaviors.
Trial registration:
The study was approved by the Institutional Review Board of The Eye Hospital of Wenzhou Medical University (NO. 2021-118-K-100-01) and was registered in the Chinese Clinical Trial Registry on 01/10/2021 (http://www.chictr.org.cn, ChiCTR2100051702).
Mapping research to the Sustainable Development Goals (SDGs)
Authors: Wang Weiwei , Kang Weihao , Mu Jingwen 
Published: February 2023

Abstract
The United Nations' 2030 Agenda for Sustainable Development provides a shared blueprint for peace and prosperity for people and the planet using 17 interlinked global goals commonly known as the Sustainable Development Goals (SDGs). Mapping research publications in concordance with the SDGs is important in understanding research activities and intensities in supporting each of the SDGs at global, country, institutional, and individual levels. Such mapping is challenging as what research outcomes and innovations belong to a specific SDG category is subject to interpretation and can be highly complex and contextual. Several SDG mapping approaches have been proposed and tested by organisations and researchers, but tend not to produce consistent mapping results. In this study, an enhanced method to conduct SDG research mapping, Auckland Approach, is proposed based on the pioneering SDG mapping work conducted by Elsevier, Sustainable Development Solutions Network (SDSN), and United Nations (UN). The Auckland Approach uses text-mining techniques and n-gram analyses to extract global and local SDG keywords from publication metadata (i.e. title, keywords, and abstracts). The keywords are sorted according to the number of publications that contain the terms, and the keywords' term frequency–inverse document frequency (tf-idf) values, respectively. After result validation, the top-ranked terms (i.e., top 200) are manually reviewed to retain keywords that are meaningful and relevant. The selected keywords are combined with those adopted by Elsevier, SDSN, and UN SDG Indicators to form our final SDG keyword lists, and the corresponding bibliometric queries are compiled. The Auckland Approach can capture more publications of the University of Auckland with the enhanced set of SDG keywords and queries than other prevalent SDG mapping approaches. Our approach promotes an SDG mapping that is data-driven, transparent, comprehensive, and contextualised. The Auckland Approach also provides an example of forming local SDG narratives and themes from a generic, global approach to make a research mapping more relevant to its local communities and research priorities.
Vertical Line through the Glabella Point as the Optimized Reference Line of Ideal Maxillary Sagittal Position During Orthognathic Surgery Planning for Chinese Adult Skeletal Malocclusion Patients: A Case-Control Study
Authors: Yang Yan , Chang Shiping , Liang Yuan , Wang Weijia , Tian Lei , Jin Zuolin 
Published: February 2023

Abstract
Objective
This study aimed to confirm whether the forehead of skeletal malocclusion patients could be used as a stable reference to guide diagnosis and orthognathic surgery planning.
Methods
Two parts of case-control study were designed. In first part of the study, three types of skeletal malocclusion patients were included and grouped. The forehead inclination and width were measured and set as the main outcome variables. Multiway ANOVA was performed to detect the statistic difference between skeletal malocclusion types and sex. The component ratio of the patients with the GALL falling directly on the glabella point (Gla) was analyzed. Based on the above results, second part of the study was carried out and the skeletal malocclusion patients who had completed orthodontic and orthognathic treatment were included, which was aimed to verify the values of the vertical line through the Gla as the reference line on diagnosis and guiding orthognathic surgery. Distance between maxillary incisor point and the reference line pre- and post-operation was analyzed as the main outcome variables and using Paired sample t test and one-way ANOVA.
Results
Two hundred forty-four Chinese patients were included in the first part of the study. Forehead inclination and width values showed significant differences between sexes and part of skeletal malocclusion patients. However, the large inclination and small width result in more than 90% of patients with the GALL falling directly on the Gla with no significant difference. In the second part of the study, the data of 149 patients who had completed treatment showed significant difference between the three types of patients about the distance between maxillary incisor point and the Gla reference line and nonsignificant was found after orthognathic surgery; most of the maxillary incisors fell on the line.
Conclusions
The vertical line through the Gla could be used as the reference line of ideal maxillary sagittal position for Chinese malocclusion patients.
Comparison of CT findings between basaloid squamous cell carcinoma and non-basaloid squamous cell carcinoma of the lung
Authors: Seo Yujin , Cha Yoon Ki , Kim Chu Hyun , Chung Myung Jin , Kim Tae Jung , Han Jungho , Lee Jung Hee , Yoon Hyun Jung 
Published: February 2023

Abstract
Background To compare computed tomography (CT) findings between basaloid lung squamous cell carcinoma (SCC) and non-basaloid SCC.
Methods From July 2003 to April 2021, 39 patients with surgically proven basaloid SCC were identified. For comparison, 161 patients with surgically proven non-basaloid SCC from June 2018 to January 2019 were selected consecutively. Clinical features, demographic characteristics, and CT findings were compared using chi-square test or Fisher’s exact test except for differences in means for which Student’s t-test was used. Additionally, Mantel-Haenszel test was performed to control the confounding of the presence of cavitation between basaloid and non-basaloid SCCs with tumors stratified by clinical T staging.
Results Compared with patients with non-basaloid SCC, patients with basaloid SCC had significantly (P<0.001) more frequent respiratory symptoms at the time of presentation. Regarding CT findings, endobronchial tumor growth and obstructive pneumonia or atelectasis were significantly (P=0.028) more common in basaloid SCC than in non-basaloid SCC. Compared with non-basaloid SCC, cavitation was absent (P=0.005) and internal profuse necrosis was significantly (P=0.022) less frequent in basaloid SCC. Furthermore, presence of cavitation consistently showed significant difference after the tumors stratified based on clinical T staging (P=0.015).
Conclusion Basaloid SCC had some CT findings different from non-basaloid SCC. Basaloid SCC showed more frequent endobronchial tumor growth with obstructive pneumonia or atelectasis. Internal profuse necrosis was less common, and cavitation was absent in basaloid SCC compared to non-basaloid SCC.
WITHDRAWN: Quest for Novel Plant based Therapeutic Options Against Dengue Virus NS2B-NS3 protease: An integrative computational methodology
Authors: Mukta Shamsunnahar , Ahmed Tufayel , Banik Anik , Paul Mousumi , Deb Anamika , Zohora Fatama Tous , Ahmed Sheikh Rashel 
Published: February 2023

Abstract
The Dengue virus (DENV) has caused heavy concern worldwide because of its high infectivity and mortality rate. Still, there's no specific drug or preventive medication to treat DENV infection despite comprehensive analysis by the researchers. This study was designed to demonstrate the efficacy of some plant-derived bioactive compounds against DENV by using ligand-based virtual screening methods. A total of 52 plant metabolites and 74 plant peptides were screened on the basis of their reported pharmacological activities against DENV NS2B-NS3 protease(4M9T) employing a molecular docking approach. Furthermore, the ADMET properties were also predicted for screened top candidates i.e., gossypol, theaflavin, cycloviolacin O24,and cycloviolacin H3. Results showed that screened top candidates i.e., gossypol, theaflavin, cycloviolacin O24, and cycloviolacin H3 provide the highest binding affinity to the targeted DENV protein. The Crucial binding sites, as well as drug surfacehotspots were unraveled for viral targeted protein. The analysis of ADME properties exhibited that none of the compounds had side effects that would reduce their drug-like properties. As compared, the toxicity pattern analysis has unmasked the non-toxic essence of screened drug candidates. The NMA analysis revealed the docked complex was compact and it demonstrated its resistance to deformation. These results may lead to the development of effective anti-DENV natural medicines. Further in vivo trials are strongly recommended.
Fournier's Gangrene and fecal diversion. When, in which patients, and what type should I perform?
Authors: Ferrete Ana Ortega , López Enrique , Sáez Luz Divina Juez , García-Pérez Juan Carlos , Ocaña Juan , Ballestero Araceli , Fernández-Cebrián Jose María , Trill Javier Die 
Published: February 2023

Abstract
Introduction
Fournier's gangrene (FG) is a necrotising fasciitis affecting the perineum and urogenital tissue. The mortality rate is high although early detection and aggressive debridement can reduce mortality by up to 16%. The prevalence of sequelae is very high and a colostomy is often necessary to control the perineal wound.
Material and Methods
A retrospective study was carried out to recruit all patients operated on by the General Surgery and Urology Departments with a diagnosis of GF at the University Hospital over 22 years. Mortality, The Fournier Gangrene Severity Index (FGSI) and fecal diversion (either surgical (colostomy) or straight (Flexi-seal)) are collected.
Results
A total of 149 patients met the inclusion criteria. FG´s most frequent cause was a perianal abscess (107 patients - 72%). 18 patients (12%) died of a specific cause of FG. Age (p=0,014) and patients with an oncological history (p=0,038), both were the only mortality risk factors for mortality according to logistic regression. 50 patients required some form of fecal diversion in the postoperative period (32 colostomies and 18 flexi-seal). Neither the use of postoperative fecal diversion (surgical or Flexi-seal) nor the timing of its use had any effect on postoperative mortality.
Conclusions
One in eight patients died in the immediate postoperative period secondary to FG. Despite improved outcomes, 22% required a colostomy during admission. However, neither the performance of a colostomy nor the timing was associated with decreased FG-associated mortality. Non-invasive methods should be used first and surgical bowel diversion should be postponed as long as possible.
Post-transplant cyclophosphamide for unrelated donor peripheral blood stem cell transplant with special attention to graft content and the impact of a higher γδ T cell dose
Authors: Wagner John , Jeurkar Chetan , Leiby Benjamin , Rashid Shaik , Gergis Usama , Grosso Dolores , Carabasi Matthew , Filicko-O'Hara Joanne , O'Hara William , Klumpp Thomas , Porcu Pierluigi , Flomenberg Neal 
Published: February 2023

Abstract
In this study, PtCy was used in 44 patients along with mycophenolate and tacrolimus with HLA matched (29) and mismatched (15) unrelated. The study was done to determine the impact of graft content on outcome thus all patients had flow cytometric analysis of their graft content including the number of B cells, NK cells, and various T cell subsets. Of the 15 patients with HLA mismatched donors, 12 were one antigen mismatched and 3 were 2 antigen mismatched. Sixteen (36.3%) of the patients developed acute GVHD (without any grade IV acute GVHD). For all patients the median time to ANC engraftment was 18 days while median time to platelet engraftment was 24 days. Mean estimated overall survival was 59.9 months, median overall survival was not reached. Higher γδ T cell dose was associated with the development of acute GVHD (p=0.0038). The use of PtCy in addition to MMF and tacrolimus has been shown to be a reasonable strategy to successfully engraft with unrelated donors. This method, potentially with the added intervention of selective gamma-delta T cell depletion, could increase transplant feasibility in recipient-donor combinations with greater HLA disparity and ensure that ethnic minorities have greater access to stem cell transplants.
Usefulness of 68Ga-PSMA PET/CT for diagnosis and clinical decision-making for radioiodine-refractory differentiated thyroid cancer
Authors: Shi Yangrui , Feng Yuyue , Xu Lu , Li Wenbo , Guan Lili , Zuo Rui , Liu Shuang , Pang Hua , Wang Zhengjie 
Published: February 2023

Abstract
Background We are looking for the diagnosis and treatment of radioiodine-refractory differentiated thyroid cancer (RAIR-DTC). Studies have shown that prostate-specific membrane antigen (PSMA) is expressed in thyroid cancer. The purpose of our study is to evaluate the clinical usefulness of 68Ga-PSMA PET/CT for the diagnosis of thyroid cancer.
Methods This prospective study included 23 DTC patients and 17 RAIR-DTC patients. The patients underwent 68Ga-PSMA PET/CT and 18F-FDG PET/CT imaging. The SUVmax and SUVmean of the lesions were measured and used to calculate CT density-corrected values. The target-to-background ratios (TBRs) were calculated. Immunohistochemical analysis of PSMA was performed on 12 human thyroid cancer biopsy samples.
Results The detection rates of DTC and RAIR-DTC by 68Ga-PSMA PET/CT were significantly lower than those by 18F-FDG PET/CT. In both the DTC and RAIR-DTC groups, the TBRmean was higher on 68Ga-PSMA PET/CT than on 18F-FDG PET/CT. The SUVmax on 18F-FDG PET/CT was positively correlated with the T stage. However, there was no correlation between the SUVmax on 68Ga-PSMA PET/CT and any clinical parameter. Immunohistochemical expression of PSMA showed a significantly higher H-score for RAIR-DTC than for DTC. However, there was no significant correlation between PSMA expression and the SUVmax on 68Ga-PSMA PET/CT.
Conclusion Although 68Ga-PSMA PET/CT was useful for detecting DTC and RAIR-DTC, its detection rate was lower than that of 18F-FDG PET/CT. 68Ga-PSMA PET/CT cannot distinguish DTC from RAIR-DTC, while 18F-FDG PET/CT is useful for the differential diagnosis of DTC and RAIR-DTC. PSMA was expressed at a higher level in RAIR-DTC. PSMA uptake on 68Ga-PSMA PET/CT was not significantly correlated with PSMA expression or tumor differentiation.
Tuning the growth of faceted Na3Zr2(SiO4)2PO4 NASICON-type solid electrolyte and its effect on microstructure-conductivity relationship
Authors: Chong Man Kit , Zainuddin Zalita , Omar Fatin Saiha , Jumali Mohammad Hafizuddin Hj 
Published: February 2023

AbstractNASICON-like Na3Zr2(SiO4)2PO4(NZSP) ceramic solid electrolyte with high ionic conductivity, safety and durability becomes the main focus and attention as an alternative for traditional liquid electrolytes. NZSP containing NH4H2PO4and Na3PO4⋅12H2O as the phosphate source have been extensively studied as a solid electrolyte, but a deep understanding of the relationship between crystal growth and ionic conductivity is still lacking. Herein, we synthesized NZSP via solid-state reaction using NaH2PO4as the phosphate source. The impact of different sintering holding time on the crystal phase, microstructure, ionic conductivity and relaxation time of NZSP solid electrolytes were investigated. Microstructure studies revealed that the faceted NZSP sintered at 1100°C for 24 h has the lowest formation ZrO2, highest densification with the least pores. In addition, the sample achieved the highest room temperature ionic conductivity (4.11 ⋅ 10− 4S cm-1) and the shortest relaxation time (0.4 µs), which is also are crucial factors for the development of rechargeable all-solid-state batteries (ASSBs).