bluuebunny/crossref_metadata_2025_split huggingface dataset:
Driving Diversity and Inclusion in Cancer Drug Development – Industry and Regulatory Perspectives, Current Practices, Opportunities, and Challenges
Authors: Fashoyin-Aje Lola A. , Tendler Craig , Lavery Bea , Ghiorghiu Serban , Gerald Brittany , Kalidas Chitkala , Richie Nicole , Winson Kathleen , Warren Nicholas J.H. , Tellman Tristen V. , Retzlaff Jon , Foti Margaret , Pazdur Richard 
Published: June 2023

Abstract
In April 2022, the FDA issued draft guidance to help industry develop strategies to improve diversity in clinical trials. Historically, clinical trial sponsors have not systematically incorporated efforts to promote diversity, equity, and inclusion (DEI), particularly during the early design stages of clinical development plans and operational strategies. Unfortunately, a retrospective approach to DEI often results in clinical trial participants not being reflective of the diversity of patients intended to be treated with new therapies. A shift to prospective, intentional DEI strategies for clinical trials, including long-term engagement with diverse patients and communities throughout the development life cycle, is necessary to maximize the benefits and minimize the risks of new drugs and devices for all patients. Sponsors’ current practices and opportunities for improving DEI address four major topics: institutional commitment, culture change, and governance; clinical development strategy; setting enrollment goals to ensure trial participant diversity; and development and implementation of the operational strategy. As DEI practices gain wider adoption in clinical trials, shared learning and collaboration among stakeholders on an ongoing and noncompetitive basis will lead to sustainable change. Prioritization of enrollment of diverse populations as an integral part of study start-up planning, clinical trial design, and recruitment capabilities will enhance the clinical development process for oncology therapies. Importantly, these efforts will help provide equitable access to clinical trials and innovative cancer therapies.
D’Alembert’s Cosmological View of the Sciences and its Legacy in Kant
Authors: Howard Stephen 
Published: June 2023

Abstract
This paper examines Jean le Rond d’Alembert’s views of metaphysical cosmology and argues that these constitute an important context for Kant’s critical-period response to rational cosmology. D’Alembert is commonly taken to have dismissed cosmology from the roster of the legitimate sciences, and there is indeed evidence of his scepticism towards Maupertuis’ cosmology no less than towards Wolff’s cosmologia generalis. I argue, however, that a broadly Leibnizian cosmological perspective underpins d’Alembert’s accounts of our knowledge and of the task of the philosopher. D’Alembert’s work thus anticipates and helps bring into focus Kant’s own nuanced engagement with the cosmological tradition.
Metrical passages in the Khotanese Saṃghāṭa-sūtra
Authors: Sims-Williams Nicholas 
Published: June 2023

Abstract
The Buddhist Sanskrit Saṃghāṭa-sūtra includes several longer or shorter passages in verse, mostly ślokas. Many though not all of these verse passages also appear in metrical form in the Khotanese version, which makes use of all three of the metres known from the longest Old Khotanese poem, the Book of Zambasta. The aim of the present article is to analyse these metrical passages in order to determine to what extent the treatment of the metres conforms to the practice of the Book of Zambasta. The relevant passages are therefore presented with a detailed metrical analysis as well as an English translation and brief commentary.
The Adhālaka-Mahācetiya at Kanaganahalli as a Political Monument
Authors: von Hinüber Oskar 
Published: June 2023

Abstract
The discovery of the Adhālaka-Mahācetiya, whose name survives in various inscriptions from the site, is among the major archaeological finds in India during the 20th century. Numerous excellently preserved images and inscriptions have substantially broadened the knowledge of Buddhist art, and, perhaps more important, allow certain conclusions on the relationship of the Buddhist Saṃgha and the ruling Śātavāhana dynasty. When comparing the corpora of inscriptions within the world of images found at other previously known Buddhist sites such as Sāñcī or Nāgārjunakoṇḍa, Kanaganahalli emerges as a unique place where politics of both the Saṃgha and the Śātavāhanas are documented. The interpretation of some royal images with their inscriptions seems to allow a rare glimpse into Śātavāhana foreign policy, particularly into their relationship with their rivals, the Kṣatrapa rulers of western India. Lastly, some images such as those of Aśoka show that Mauryan rule was not forgotten at Kanaganahalli, which is very close to the site of nearby Sannati (a find spot of Aśokan edicts). At the same time these images and their very prominent position on the Adhālaka-Mahāceitya prove keen awareness and interest in events of the past by those who designed the program for decorating the monument.
A Step Forward in Reaching toward the Indo-Iranian Background of the Avestan and Vedic Liturgies
Authors: Sadovski Velizar 
Published: June 2023

Abstract
This survey discusses a series of achievements in comparative Indo-Iranian studies, on the occasion of the appearance of a new representative volume. The presentation of these achievements aims to trace existing and new directions of scholarly co-operation between Vedists, Avestologists, specialists in Achaemenid and Sassanian studies, as well as, more generally, between Indo-Europeanists, philologists and scholars of history of culture and religions with the aim to continue the reconstruction of Indo-Iranian sacred texts and religious practices.
The Treasury Image of Mariazell: The Materialisation of Hope, Assurance and Security
Authors: Zika Charles 
Published: June 2023

Abstract
One of the key sacred objects at the Austrian pilgrimage shrine of Mariazell is the Schatzkammerbild or Treasury Image, a late fourteenth-century painting of the Virgin and child in the style of a metal-encased and adorned Byzantine icon. Originally commissioned by King Louis I of Hungary, it was later donated to Mariazell. This essay traces significant changes in the life of this precious object over approximately four centuries, focusing on how its materiality was meant to stimulate feelings of hope and assurance concerning public security. From votive image given in thanks for a miraculous victory, it was transformed into a powerful heavenly object to be used against the threats of Ottoman and Protestant enemies. Then from the 1670s it began to be appropriated by its Habsburg patrons as an assurance of the security they could provide against individual and collective threat, as King Louis had done in the past.
Transformative Experiences of Intercessory Prayers in a South African Context of Xenophobia
Authors: Nishimwe Clementine 
Published: June 2023

Abstract
This paper explores the effect of intercessory prayers as experienced by Black African migrant women in the context of xenophobia. Drawing on an ethnographic study of the experiences of Black African migrant women at St Aidan’s Anglican Church (saac), located in a migrant-dominated area in Johannesburg, I discuss the transformative experiences of health, wealth and relationships resulting from intercessory prayers that challenged the context of xenophobia in which saac functioned. While the transformation observed in the study was limited in time and space, I argue that certain church practices can be transformative if intentionally designed in ways that are sensitive to the specific context in which that church functions.
Doing Research with People Experiencing Profound Autism
Authors: Tam Cynthia 
Published: June 2023

Abstract
Researching with persons using limited speech for communication can be challenging. This paper describes methodological considerations in the research process from recruitment to data collection. A case study is included to illustrate the considerations involved in selecting appropriate qualitative research methods to support people with profound autism to be involved in research. Involving people with profound autism in ecclesial studies is essential as it allows them to speak directly into the place of faith in their lives and their needs for a faith community. Recognizing that people with profound autism are competent informants in research, combined with using suitable tools, will also allow us to understand the gifts and indispensability of this group of people to the church.
What Lucifer Taught Me About How to Be a Christian: Towards an Apophatic Ethnography
Authors: Blankenship Paul Houston 
Published: June 2023

Abstract
This article aims to crack open the structure of ethnographic theology. It challenges our Christian faith to nurture our love for the world, Christian and otherwise. This article is based on extensive ethnographic fieldwork with young adults experiencing homelessness in Seattle who claim to be Luciferians and hate Christianity. I query what difference an ethnographic theologian’s personal faith makes from field to text and then back to field. What really matters about ethnographic theology, I propose, is participation in the transformative power of divine love through contemplative action that necessitates apophatic practice. I demonstrate how my own apophatic ethnographic practice(s) helped me understand what is at stake with Luciferians on the streets of Seattle and take contemplative action. I also disclose a fruit of my apophatic practice: a transformed perspective on Luciferianism where I came to experience Christ in Lucifer’s wounds and the Luciferian rejection of and disgust for Christianity.
Sans érasure
Authors: Greenstein Edward L. 
Published: June 2023

Abstract
A curious phenomenon that is attested in the Ugaritic texts, elsewhere in the ancient Near East, the Hebrew Bible, the Dead Sea Scrolls, medieval texts, and beyond is a scribal practice I call sans érasure, a case in which a scribe leaves an error uncorrected and proceeds to write or copy the correct letter, word, line, or verse following the error. In this article, a number of rather clear examples are adduced from the Ugaritic texts, and a number of examples from the Hebrew Bible are proposed. Several of these cases would seem to be recognized in the Masoretic tradition in instances of ‮לא קרי‬‎ (written but not read). Some of the biblical examples resolve longstanding philological cruxes. Among the examples are several from the book of Job and the last verse in Lamentations. An explanation for the practice is suggested.
Predictive Factors and Audiometric Outcome Comparison Between Titanium Prosthesis and Autologous Incus in Traumatic Ossicular Injury
Authors: Chien Chen-Yu , Tai Shu-Yu , Chan Leong-Perng , Wang Hsun-Mo , Chang Ning-Chia , Wang Ling-Feng , Ho Kuen-Yao , Li Kuan-Hui 
Published: June 2023

Objectives: To investigate the etiology and ossicular pathology of traumatic ossicular injury in Taiwan and examine the hearing outcomes and predictive factors between the titanium prosthesis and autologous incus groups. Methods: We retrospectively analyzed patients with traumatic ossicular injury from 2011 to 2020 in Taiwan. Patients were divided into the titanium or autologous group according to the surgical materials used. The audiometric outcomes and predictive factors of ossiculoplasty were analyzed between groups. Results: Twenty patients with ossicular chain discontinuity were enrolled (8 in the titanium group and 12 in the autologous group). The postoperative hearing threshold (26.6 ± 8.9 dB) and air-bone gap (10.3 ± 5.6 dB) improved significantly compared with the preoperative hearing threshold (50.7 ± 13.3 dB) and air-bone gap (29.9 ± 11.0 dB). The improvements in the hearing threshold and air-bone gap were not significantly different between the titanium and autologous groups. Our patients presented an improvement in hearing restoration with 65% closure of the air-bone gap in 0 to 10 dB range and 30% in 11 to 20 dB range, without sensorineural hearing loss during surgery. Univariate regression analysis revealed that vertigo, benign paroxysmal positional vertigo, and temporal bone fracture may serve as negative factors influencing the air-bone gap gain. Conclusions: Ossiculoplasty with both titanium prosthesis and autologous materials demonstrated favorable hearing recovery in traumatic ossicular injury. Vertigo, benign paroxysmal positional vertigo, and temporal bone fracture may serve as negative predictive factors of the hearing benefit after surgery.
Development of artificial neural network models for indirect evaporative coolers in multi-climate regions based on field measurement
Authors: Sun Tiezhu , Sun Huan , Chen Yi , Huang Xiang , Chu Junjie 
Published: June 2023

Data-driven artificial neural networks (ANN) based on data drivers with their powerful self-learning capability and high adaptability are gaining increasing attention for the application in modeling indirect evaporative coolers (IEC). However, most ANN models of IEC in existing studies are either limited to a specific climate region or conventional IEC configurations. In this paper, a multi-region back-propagation (BP) neural network model for predicting the performance of advanced dew-point IECs is developed. Operational data for ANN model development were collected through field measurements in IEC projects in three typical climate zone cities in China (Dunhuang, Yulin, and Fuzhou), covering arid, moderately wet, and humid regions. A comparative study of three single-region neural network models was conducted in terms of both convergence characteristics and statistical performance metrics. Each model contains two input variables (inlet air temperature, inlet air humidity) and one output variable (wet-bulb efficiency). The results show that the model fits best in Yulin, followed by Dunhuang and Fuzhou, with total correlation coefficients of 0.9918, 0.9477, and 0.8946, respectively. The predicted values of wet-bulb efficiency are in good agreement with the actual operating data, and the deviation of almost all predicted values is within ±10%. Practical application The application values of IEC ANN models are as follows. First, the IEC-ANN model can predict IEC performance adaptively based on dynamic operational data. Therefore, it can provide the best operating strategy and design parameters for different situations. In addition, it can provide a fast response to guide the system operation when auxiliary control is required. Most importantly, this new approach requires only a limited number of tests rather than exhaustive experimental studies or dealing with complex mathematical models, and future manufacturers can use neural network technology to evaluate the performance of dew-point indirect evaporative coolers, thus saving engineering budget and time.
Ultrasound-based radiomic analysis of the peripheral nerves for differentiation between CIDP and POEMS syndrome
Authors: Hashiba Jun , Yokota Hajime , Abe Kota , Sekiguchi Yukari , Ikeda Shinobu , Sugiyama Atsuhiko , Kuwabara Satoshi , Uno Takashi 
Published: June 2023

Background Demyelinating peripheral neuropathy is characteristic of both polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP). We hypothesized that the different pathogeneses underlying these entities would affect the sonographic imaging features. Purpose To investigate whether ultrasound (US)-based radiomic analysis could extract features to describe the differences between CIDP and POEMS syndrome. Material and Methods In this retrospective study, we evaluated nerve US images from 26 with typical CIDP and 34 patients with POEMS syndrome. Cross-sectional area (CSA) and echogenicity of the median and ulnar nerves were evaluated in each US image of the wrist, forearm, elbow, and mid-arm. Radiomic analysis was performed on these US images. All radiomic features were examined using receiver operating characteristic analysis. Optimal features were selected using a three-step feature selection method and were inputted into XGBoost to build predictive machine-learning models. Results The CSAs were more enlarged in patients with CIDP than in those with POEMS syndrome without significant differences, except for that of the ulnar nerve at the wrist. Nerve echogenicity was significantly more heterogeneous in patients with CIDP than in those with POEMS syndrome. The radiomic analysis yielded four features with the highest area under the curve (AUC) value of 0.83. The machine-learning model showed an AUC of 0.90. Conclusion US-based radiomic analysis has high AUC values in differentiating POEM syndrome from CIDP. Machine-learning algorithms further improved the discriminative ability.
Our Work is International Relations: On Exclusion, Negotiation, and Engagement Against Disciplinary Boundaries
Authors: Hagen Jamie J. , Ranawana Anupama 
Published: June 2023

With this forum we aim to contribute to the debate within International Relations (IR) scholarship about the space that has opened up since the inter-paradigmatic debate 30 years ago and the challenges still experienced by those of us coming from the “margin” yet committed to the “globalization” of the discipline. That is to say, to building a pluriverse of IR. In the first contribution Anupama Ranawana begins by considering the practical difficulties for Southern research and knowledge creation in IR, detailing a snapshot of how current funding structures continue to relegate academics and researchers in the Global South to a relationship of dependency on their counterparts in the Global North. The next two contributions to the discussion reflect on how these problematic bounds of the disciple are then embodied by those of us working in more marginal spaces in IR. First, Ahmed Rizky Mardhatilla Umar writes of the policing of IR within the Indonesian University which continues to leave most critical work as outside of IR. Another point of embodied experience in what for many continues to be marginal or even outside of the discipline is considered by Jamie J. Hagen and Alex Edney-Browne who write about queer IR and specifically the experience of being a part of a community of LGBTQA (lesbian, gay, bisexual, transgender, queer and allies) in IR scholars. In conclusion Roland Bleiker reflects and evaluates “the potential and limits of International Relations as an academic discipline” even as the discipline continues to call for greater diversity. As such, each contributor speaks separately to a jointly articulated provocation regarding what counts and is centered as “real” International Relations scholarship, based on their own encounters with being told explicitly (i.e., through rejections, lack of institutional support) or implicitly (i.e., through what we are taught) that our work is not International Relations.
Thermal decomposition features of micro-nano rice husk/polylactic acid blends for 3D printing
Authors: Sun Yufeng , Wang Jinwei , Wang Yapeng , Zhang Ziheng , Zheng Zipeng , Yang Bin , Mu Wenlong , Ying Jilai , Li Defeng , Xu Guangyin 
Published: June 2023

The thermal decomposition process of 3D printed filament made from micro-nano rice husk (MNRH)/polylactic acid (PLA) blends was studied by dynamic thermogravimetric analysis. The characteristic temperatures and apparent activation energies of unmodified, single modified, and double modified RH/PLA composites were calculated by Friedman (FD), Flynn-Wall-Ozawa (FWO), Coats-Redfern (CR), and Kissinger (KS) kinetic models. With the modification of MNRH and PLA in the composites, the initial thermal decomposition temperature of the composite increased from 236.3°C to 244°C. At the same time, the thermal degradation degree decreased and the transition temperature interval increased. The apparent activation energy (AAE) values of different modified composites ranged from 90 to 120 kJ/mol, depending on the modification method and calculation method of the material. These four kinetic models provide methods to analyze the thermal stability of composites. It is helpful to known the thermal decomposition behavior of MNRH/PLA composites, and it will contribute to the development of MNRH/PLA filament for 3D printing in the application of automotive interior parts production.
Active Aging in Senior Housing Residents and Community-Dwelling Older Adults: A Comparative Study in Finland
Authors: Siltanen Sini , Keskinen Kirsi E. , Lahti Anna-Maria , Rantanen Taina , von Bonsdorff Mikaela 
Published: June 2023

Objectives Leading an active life in old age underpins positive life experience. This study aimed to compare the levels of active aging in senior housing residents and community-dwelling older people. Methods We combined data from the BoAktiv senior house survey (N = 336, 69% women, mean age 83 years) and AGNES cohort study among community-dwelling older adults (N = 1021, 57% women, mean age 79 years). Active aging was assessed with the University of Jyvaskyla Active Aging scale. Data were analyzed with general linear models, and the analyses were stratified by sex. Results Men in senior houses demonstrated lower active aging scores in general than community-dwelling men. Women in senior houses showed greater will to be active, but poorer ability and possibilities for activity than community-dwelling women. Discussion Despite the social and supporting environment, senior housing residents’ possibilities for leading an active life seem to be compromised, potentially leading to an unmet activity need.
First study of genital HPV infection among women living with HIV recruited from May to September 2018 in Eastern Algeria
Authors: Rais M , Ouyahia A , Mohammedi D , Sadouki N , Laouamri S , Abdoun M , Gasmi A , Lacheheb A 
Published: June 2023

Background Genital HPV infection is recognized worldwide as one of the most common, if not the most common, sexually transmitted infection. Several studies have shown a higher prevalence of HPV infection in women living with HIV (WLWH). We aimed to determine the prevalence of HPV, the circulating genotypes, and its association with risk factors among Algerian WLHIV. Methods Cervical specimens were collected from 100 WLHIV. The detection of HPV infection was performed by Roche Linear Array test. Results The overall prevalence of HPV infection was determined at 32%, all including high risk HPV (HR-HPV). We found a great diversity of HR-HPV genotypes, the most common individually were HPV52, HPV16, HPV18 and HPV58, The highest prevalence was found in groups of genotype 52, 25%. HPV16 and 18 were less common (16%). Cervical cytology was abnormal in 66% (81.3% in the HPV + population), with a predominance of inflammatory lesions (75% HPV +), The most important determining risk factor for HPV infection in this series was a low CD4 T cell count <200/mm3 found in 72% of the HPV positive participants. Conclusion Our study is an initial database, to be completed by a multicenter study to determine the most frequent genotypes in Algerian WLHIV, in order to discuss the introduction of the vaccine against HPV in Algeria, especially among WLHIV.