bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Entropy Enabling the Reversible Redox Reaction of V4+/V5+ Couple in NASICON‐Type Sodium Ion Cathode
Authors: Li Meng , Sun Chen , Ni Qing , Sun Zheng , Liu Yang , Li Yang , Li Lei , Jin Haibo , Zhao Yongjie 
Published: February 2023

AbstractNASICON‐type Na3VM(PO4)3 (M: transition metals) cathodes usually suffer from poor cycling stability in the voltage region of above 4 V versus Na+/Na owing to irreversible phase transition and severe structural distortion. Herein, the high entropy concept is extended to NASICONs and Na3VAl0.2Cr0.2Fe0.2In0.2Ga0.2(PO4)3 (NVMP) with high purity is obtained. The NVMP achieves a highly reversible specific capacity of 102 mAh g−1 (2.5–4.4 V vs Na+/Na) via the successive redox reaction of V3+/V4+/V5+ together with a long‐term lifespan of 5000 cycles at 20 C (a capacity retention of 86.8%). Even at an extreme temperature of −20 °C, the NVMP cathode can still provide excellent cycling performance (a capacity retention of 94.2% at 5 C after 1000 cycles). Moreover, the increased configurational entropy in the electrode renders a quite small cell volume change of 1.1%. The sodium ion storage mechanism containing solid solution‐type in the voltage range of 2.5–3.8 V and bi‐phasic in 3.8–4.4 V is revealed by ex situ XRD analysis. Pairing with a hard carbon anode, NVMP//HC cell offers a specific capacity of 81 mAh g−1 at 0.2 C based on the cathode mass. This high‐entropy engineering is expected to be widely applicable for the development of polyanionic electrode materials.
Using simulated rainfall to evaluate cover crops and winter manure application to limit nutrient loss in runoff
Authors: Bhandari Ammar B. , Gelderman Ronald , German David R. , Kharel Tulsi P. 
Published: February 2023

AbstractCover crops can be effective in minimizing nutrient losses from agricultural fields. The objective of this study was to determine the impact of cover crop (rye,Secale cerealeL.) and winter manure application on nutrient loss in simulated rainfall runoff. A split block design study with manure (as vertical block) and cover crops (as horizontal block) was established in 2009. Two rain simulations (the first defined as “dry” and the second “wet”) using sixteen 4 m2steel frames were conducted in May 2010. The runoff volume collected from each plot was analyzed for nitrate–nitrogen (NO3–N), total suspended solids, total Kjeldahl nitrogen, total phosphorus, and total dissolved phosphorus. In the dry run, the concentration and load of NO3–N were significantly lower (p = 0.05) in runoff with the cover crop than in no‐cover crop treatment. Overall, cover crops reduced nutrient loss in concentration by 6%–48% in the dry and 8%–40% in the wet run than with no‐cover crops. The concentration and load of NO3–N were significantly higher under manure treatments in both “dry” and “wet” runoff runs compared to no‐manure application. Manure application increased nutrient loss in concentration by 6%–58% in the dry and 10%–69% in the wet run than with no‐manure application. This study helps us to understand the complexity of winter manure application with cover crops and potential risks of nutrient loss to surface runoff during spring in the Northern Great plains of the Dakotas.
Comparative transcriptome analysis of conventionally cultivated tobacco and tobacco grafted to eggplant
Authors: Zhang Mengyue , Zhao Yuanyuan , Shi Hongzhi 
Published: February 2023

AbstractTobacco (Nicotiana tabacum L.) grafted to eggplant (Solanum melongena L.) has been shown to limit nicotine content, however, the molecular mechanism of this graft combination remains unclear. In this study, we performed a genome‐wide transcriptional analysis of Zhongyan‐100 leaves, that were conventionally planted and grafted onto eggplant rootstocks, using high‐throughput sequencing. The nicotine content in the leaves of the tobacco/eggplant grafting group was significantly decreased compared to the tobacco group. A total of 2389 differentially expressed genes (DEGs) were identified between the tobacco/eggplant group and tobacco group. Functional annotation revealed that many DEGs were involved in glutathione and linoleic acid metabolism, and phenylpropanoid, sesquiterpenoid, and triterpenoid biosynthesis. To explore whether nicotine level in tobacco changes after grafting, the expression of PMT, QPT, A622, and BBLa in the roots and stems was elucidated using quantitative PCR. This study found that the expression of these genes in the roots of the tobacco/eggplant group was significantly lower than that in the tobacco group. In addition, the expression of PMT, A622, and BBLa in tobacco stems of the tobacco/eggplant group was significantly higher than those in tobacco stems of the tobacco group and leaves of the tobacco/eggplant group. Our comprehensive analysis provides basic information on the genes and metabolic signaling pathways involved in Zhongyan‐100/eggplant grafting. Additionally, this study found that the expression of nicotine‐related genes changed during the grafting process; however, the specific molecular mechanisms underpinning this effect requires further exploration.
The evolution of workplace risk for Covid‐19 in Canadian healthcare workers and its relation to vaccination: A nested case‐referent study
Authors: Cherry Nicola , Mhonde Trish , Adisesh Anil , Burstyn Igor , Durand‐Moreau Quentin , Labrèche France , Ruzycki Shannon 
Published: February 2023

AbstractBackgroundDuring the early months of the Covid‐19 pandemic, studies demonstrated that healthcare workers (HCWs) were at increased risk of infection. Few modifiable risks were identified. It is largely unknown how these evolved over time.MethodsA prospective case‐referent study was established and nested within a cohort study of Canadian HCWs. Cases of Covid‐19, confirmed by polymerase chain reaction, were matched with up to four referents on job, province, gender, and date of first vaccination. Cases and referents completed a questionnaire reporting exposures and experiences in the 21 days before case date. Participants were recruited from October 2020 to March 2022. Workplace factors were examined by mixed‐effects logistic regression allowing for competing exposures. A sensitivity analysis was limited to those for whom family/community transmission seemed unlikely.Results533 cases were matched with 1697 referents. Among unvaccinated HCWs, the risk of infection was increased if they worked hands‐on with patients with Covid‐19, on a ward designated for care of infected patients, or handled objects used by infected patients. Sensitivity analysis identified work in residential institutions and geriatric wards as high risk for unvaccinated HCWs. Later, with almost universal HCW vaccination, risk from working with infected patients was much reduced but cases were more likely than referents to report being unable to access an N95 mask or that decontaminated N95 masks were reused.ConclusionsThese results suggest that, after a rocky start, the risks of Covid‐19 infection from work in health care are now largely contained in Canada but with need for continued vigilance.
Natural history of MRAS‐related Noonan syndrome: Evidence of mild adult‐onset left ventricular hypertrophy and neuropsychiatric features
Authors: Priolo Manuela , Mancini Cecilia , Radio Francesca Clementina , Chiriatti Luigi , Ciolfi Andrea , Cappelletti Camilla , Cordeddu Viviana , Pintomalli Letizia , Brusco Alfredo , Mammi Corrado , Tartaglia Marco 
Published: February 2023

AbstractGain of function pathogenic variants in MRAS have been found in a small subset of pediatric subjects presenting with Noonan syndrome (NS) associated with hypertrophic cardiomyopathy (HCM) and moderate to severe intellectual disability. These variants are considered to confer a high‐risk for the development of severe HCM with poor prognosis and fatal outcome. We report on the natural history of the first adult subject with NS carrying the recurrent pathogenic p.Thr68Ile amino acid substitution. Different from what had previously been observed, he presented with a mild, late‐onset left ventricular hypertrophy, and a constellation of additional symptoms rarely seen in NS. The present case provides evidence that HCM does not represent an obligatory, early‐onset and severe complication in subjects with MRAS variants. It also adds new data about late‐onset features suggesting that other unexpected complications might be observed in adult subjects providing anticipatory guidance for individuals of all age.
Advancing precision medicine in medical education: Integrated, precise and data‐driven smart solutions
Authors: Papadopoulou Paraskevi , Lytras Miltiadis 
Published: February 2023

AbstractAdvances in “Precision Medicine” initiative, also known as “Personalized Medicine” is an emerging approach for disease treatment and prevention that has already led to innovative discoveries and has created “smart” applications and solutions tailored to a person's or a group of individuals' genetic profile, lifestyle, and environment interaction. Already many physicians as part of patient care routinely prescribe various molecular/genetic and other tests enabling them to select personalized treatments that improve the chances of survival and reduce exposure to adverse effects. This initiative should provide to medical and healthcare professionals with adequate resources and readily available solutions so that the target to specific treatments and care of the illnesses is achieved while at the same time protecting the privacy and safety of the individual is secured as well as the Electronic Health Records (EHRs) and whatever additional data is necessary within the context of Precision Medicine. This study, through a literature review mostly, and some case study analysis, examine whether personalized medicine is delivered to the patient in an “accurate” and “precise” way, as expected. This requires that Health and Human Services and other stakeholders and agencies collaborate to solicit the right input from patients while at the same time can identify and address any educational, practical, legal, and technical issues and providing smart solutions. The lack of proper medical education and advanced infrastructure are still major barriers to the adoption of Precision Medicine, therefore, the role of medical training in Precision Medicine is also examined and analyzed. Specific examples are discussed in an integrated, precise, and data‐driven manner to provide “smart” solutions.
Development of a push–π–pull phenothiazine‐vinyl‐isophorone fluorophore: a novel solvatochromic and pH indicator
Authors: Alahmdi Mohammed Issa 
Published: February 2023

AbstractKnoevenagel condensation of phenothiazine‐3,7‐dicarbaldehyde with an isophorone yielded a new phenothiazine derivative (PTZ‐c) fluorophore. The solvatochromic and pH‐sensing abilities of PTZ‐c, an asymmetric fluorophore with a single isophorone molecule, were shown to be exceptional. PTZ‐c produced very delicate absorbance and emission spectra. When the polarity of the solvent was increased, the PTZ‐c emission spectra showed greater sensitivity than the absorption spectra. Multiple spectroscopic techniques, including Fourier transform infrared spectroscopy, nuclear magnetic resonance, and mass spectrometry, were used to characterize the manufactured PTZ‐c sensor. To demonstrate the beneficial solvatochromic behaviour associated with intramolecular charge transfer, the absorption spectra of the synthesized DA PTZ‐c dye were analyzed in different solvents of varying polarity. Band intensity and the wavelength of PTZ‐c emission were also found to be highly solvent dependent. It was observed that when solvent polarity was increased to a maximum of 4122 cm−1, Stokes’ shift also increased. To analyze the Stokes' shift that depended on the solvent, a linear correlation between solvation and energy was used. An investigation of PTZ‐c quantum yield (ф) was also conducted. Both the absorbance and fluorescence spectra of the sensor in dimethylformamide as a function of pH were studied. A fluorescence peak was seen at 562 nm, whereas the greatest absorption wavelengths were found at 403 and 317 nm. It was shown that the pH‐sensing mechanism depended on protons removed from the PTZ‐c chromophore, which caused a colour shift and variation in both emission and colorimetric properties.
A strategy combining chemical analysis and network pharmacology to investigate the mechanism of Xiao’er Qingre Zhike Oral solution in cough
Authors: Yang Xiao‐Yun , Zhu Yi‐Wen , Fan Li , Yi Shan‐Yong 
Published: February 2023

AbstractXiao’er Qingre Zhike Oral Solution (XQZS) is a commonly used TCM formula to treat cough in children in China. Its complicated composition renders its chemical analysis and mechanism elucidation difficult. To evaluate the bioactive components and mechanism of XQZS against cough, we used a combination strategy of chemical analysis and network pharmacology. A UHPLC/Q‐Orbitrap–MS method was established for the identification and qualitative analysis of components of XQZS, and a total of 33 components were unambiguously identified. Aiming at identifying the components, network pharmacology revealed 107 potential targets related to cough. Using protein–protein interactions analysis, nine core targets were selected. Several cough‐related pathways were enriched using the Kyoto Encyclopedia of Genes and Genomes, including neuroactive ligand–receptor interaction, serotonergic synapse and dopaminergic synapse. The herb–compound–target–pathway network indicated that PTGS2 (COX‐2) was the core target of XQZS against cough. To demonstrate the inhibition effects of the major components against the key target, a COX‐2 inhibitor screening assay was used. Compounds P2, P4, P23 and P49 exhibited promising inhibition effects on COX‐2 at 20 μm, with inhibitory rates of 55.80–69.87%. In conclusion, this study demonstrates that XQZS may alleviate cough via the inhibition of PTGS2 (COX‐2) and the regulation of the serotonergic synapse pathway. The chemical analysis and network pharmacology integrated evaluation provided an efficient strategy for discovering the key pharmacological mechanism of XQZS.
Self‐powered high‐resolution smart insole system for plantar pressure mapping
Authors: Zheng Qiuqun , Dai Xingyi , Wu Yinghui , Liang Qihua , Wu Yongpeng , Yang Jingkun , Dong Biqin , Gao Guojun , Qin Qi , Huang Long‐Biao 
Published: February 2023

AbstractAccurate plantar pressure mapping systems with low dependence on the external power supply are highly desired for preventative healthcare and medical diagnosis. Herein, we propose a self‐powered smart insole system that can perform both static and dynamic plantar pressure mapping with high accuracy. The smart insole system integrates an insole‐shaped sensing unit, a multi‐channel data acquisition board, and a data storage module. The smart insole consists of a 44‐pixel sensor array based on triboelectric nanogenerators (TENGs) to transduce pressure to the electrical signal. By optimizing the sensor architecture and the system's robustness, the smart insole achieves high sensitivity, good error‐tolerance capability, excellent durability, and short response–recovery time. Various gait and mobility patterns, such as standing, introversion/extraversion, throwing, and surpassing obstacles, can be distinguished by analyzing the acquired electrical signals. This work paves the way for self‐powered wearable devices for gait monitoring, which might enable a new modality of medical diagnosis.
Validity of pathological diagnosis for early colorectal cancer in genetic background
Authors: Okimoto Kenichiro , Hirotsu Yosuke , Arai Makoto , Amemiya Kenji , Akizue Naoki , Ohta Yuki , Taida Takashi , Saito Keiko , Ohyama Hiroshi , Matsumura Tomoaki , Nishimura Motoi , Matsushita Kazuyuki , Matsusaka Keisuke , Oyama Toshio , Mochizuki Hitoshi , Chiba Tetsuhiro , Kato Jun , Ikeda Jun‐ichiro , Yokosuka Osamu , Kato Naoya , Omata Masao 
Published: February 2023

AbstractBackgroundThis study aimed to investigate the validity of pathological diagnosis of early CRC (E‐CRC) from the genetic background by comparing data of E‐CRC to colorectal adenoma (CRA) and The Cancer Genome Atlas (TCGA) on advanced CRC (AD‐CRC).MethodsTCGA data on AD‐CRC were studied in silico, whereas by next‐generation sequencer, DNA target sequences were performed for endoscopically obtained CRA and E‐CRC samples. Immunohistochemical staining of mismatch repair genes and methylation ofMLH1was also performed. The presence of oncogenic mutation according to OncoKB for the genes of the Wnt, MAPK, and cell‐cycle–signaling pathways was compared among CRA, E‐CRC, and AD‐CRC.ResultsThe study included 22 CRA and 30 E‐CRC lesions from the Chiba University Hospital and 212 AD‐CRC lesions from TCGA data. Regarding the number of lesions with driver mutations in the Wnt and cell‐cycle–signaling pathways, E‐CRC was comparable to AD‐CRC, but was significantly greater than CRA. CRA had significantly more lesions with a driver mutation for the Wnt signaling pathway only, versus E‐CRC.ConclusionsIn conclusion, the definition of E‐CRC according to the Japanese criteria had a different genetic profile from CRA and was more similar to AD‐CRC. Based on the main pathway, it seemed reasonable to classify E‐CRC as adenocarcinoma. The pathological diagnosis of E‐CRC according to Japanese definition seemed to be valid from a genetic point of view.
Antifungal Activity, Antibiofilm and Association Studies withO‐Alkylamidoximes againstCryptococcusspp.
Authors: de Castro Teixeira Anna Paula , Fernandes Queiroga Moraes Gustavo , de Oliveira Romário Jonas , Silva Santos Cosme , Alves Caiana Rodrigo Ribeiro , Rufino de Freitas Juliano Carlo , Vasconcelos Ulrich , de Oliveira Pereira Fillipe , Oliveira Lima Igara 
Published: February 2023

AbstractThis is the first study that describes the antifungal and anti‐biofilm potential ofO‐alkylamidoximes against strains ofCryptococcus neoformansandCryptococcus gattii. In vitrotests have shown thatO‐alkylamidoximes are capable of inhibiting fungal growth and biofilm formation of theC. neoformansandC. gattiistrains, suggesting, from molecular docking, the potential for interaction with the Hsp90. The associations betweenO‐alkylamidoximes and amphotericin B were beneficial. Therefore,O‐alkylamidoximes can be a useful alternative to contribute to the limited arsenal of drugs, since they showed a powerful action against the primary agents of Cryptococcosis.
Metastatic yolk sac tumor masquerading as multifocal hepatocellular carcinoma in a young adult: A case report
Authors: Mushtaq Kamran , Khan Muhammad Umair , Al Soub Deema , Koshy Sheija Mary , Petkar Maher , Al Ejji Khalid Mohsin 
Published: February 2023

AbstractPrimary yolk sac tumor of the liver is very rare and can present as multifocal liver lesions. Multifocal nature may mimic other diagnoses such as hepatocellular carcinoma. Early recognition and therapeutic intervention are important as the prognosis of metastatic yolk sac tumors is poor. We present a case of a young adolescent who presented with bleeding per rectum abdominal pain and multiple liver lesions.
Secure Internet of Things based hybrid optimization techniques for optimal centroid routing protocol in wireless sensor network
Authors: Wasay Mudasser Abdul , Ahmed Abdul Gafoor Shah Aqueel 
Published: February 2023

SummaryThe recent survey depicts internet growth has been reached to billion of people and Internet of Things (IoT) as another milestone. IoT is wired or wireless communication technologies to establish a communication channel between devices and services available over the Internet. The wireless sensor networks (WSNs) is one of the most essential technologies assisted in IoT for real‐time applications. The energy efficiency is a major issue in IoT and it becomes more complex due to large scalability and the WSNs cannot be applied directly to the IoT. Moreover, routing is a very challenging aspect that takes place in such platform because of it is intrinsic properties. In this article, we propose an optimal centroid‐based routing protocol (OCRP) for WSN assisted IoT based on hybrid optimization techniques, which aim is to enhance the energy efficiency and network lifetime. IoT network is composed by serving nodes and end users. In OCRP, a multi‐objective swarm optimization (MSO) algorithm is used to perform the clustering, which reduce the chaotic in nature of energy consumption. Then, multiservice queue based ant optimization algorithm is proposed for next neighborhood selection for inter‐cluster routing. Finally, our OCRP protocol is experimented with different simulation in network simulator (NS‐2) tool with wireless body sensor network (WBSN) application. The simulation results show the effectiveness of OCRP protocol in terms of energy consumption, average data transmission rate and network lifetime.
Black‐hole attack and counter measure in ad hoc networks using traditional routing optimization
Authors: Pullagura Joshua Reginald , Dhulipalla Venkata Rao 
Published: February 2023

SummaryAd hoc networks have constraints like energy, memory, computation power, and communication range which makes the nodes vulnerable for attacks. In this article, black hole attack detection mechanism is carried out on traditional ad hoc on demand distance vector routing (AODV) protocol. Initially the proposed work proceeded with black‐hole attack configured on conventional AODV protocol. Black‐hole node will give route reply with highest sequence number to entice the sender to create a route through it. By using intruder detection system threshold mechanism, the black‐hole nodes are identified and isolated. In this article, maximal destination sequence number is estimated by using linear regression technique. Performance comparison is carried out with normal, black hole based and black hole detected routing mechanisms. The simulation findings show that that incorporated method enhances network performance by improving QoS under black hole attack.
Facile One‐Step Access to Pyrrole‐Based 1,4‐Diphosphabarrelenes
Authors: Werra Janina A. , Wurst Klaus , Löwe Pawel , Dielmann Fabian 
Published: February 2023

Abstract1,4‐Diphosphabarrelenes are bicyclic diphosphines relevant, for example, for the generation of polymetallic coordination compounds. However, current synthetic protocols either suffer from low yields or require multiple reaction steps. Herein, we report the one‐step synthesis of pyrrole‐based 1,4‐diphosphabarrelenes that are obtained in very good yields from the reaction of 1,2,5‐trimethylpyrrole with 1,2‐bis(dichlorophosphino)ethane or 1,2‐bis(dichlorophosphino)benzene. The new caged diphosphines are strong donor ligands and act as bridging ligand in nickel(0), rhodium(I), iridium(I) and copper(I) coordination compounds.