bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioinformatics analysis to identify potential biomarkers for the pulmonary artery hypertension associated with the basement membrane
Authors: Li Qian , Zhang Hu 
Published: September 2023

Abstract
Pulmonary arterial hypertension (PAH) is a rapidly progressing cardiopulmonary disease. It is characterized by increased pulmonary artery pressure and vascular resistance. The most notable histopathological characteristic is vascular remodeling. The changes in the basement membrane (BM) are believed to be related to vascular remodeling. It is crucial to identify potential biomarkers associated with the BM in PAH, to guide its treatment. The microarray datasets GSE117261 and GSE113439 were downloaded from the Gene Expression Omnibus. Two data sets were examined to identify genes associated with the BM by analyzing gene expression changes. Next, we analyzed the relevant genes in the Kyoto Encyclopedia of Genes and Genomes using Gene Ontology and Disease Ontology annotationand conducted pathway enrichment analysis. We conducted a protein–protein interaction network analysis on the genes related to BMs and used the cell cytoHubba plug-in to identify the hub genes. Furthermore, we conducted an immune infiltration analysis and implemented a histogram model. Finally, we predicted and analyzed potential therapeutic drugs for PAH and set up a miRNA network of genetic markers. Six candidate genes related to BMs, namely Integrin Subunit Alpha V, Integrin Subunit Alpha 4, ITGA2, ITGA9, Thrombospondin 1, and Collagen Type IV Alpha 3 Chain, were identified as potential modulators of the immune process in PAH. Furthermore, ginsenoside Rh1 was found to significantly impact drug targeting based on its interactions with the six BM-related genes identified earlier. A novel biomarker related to the BM, which plays a crucial role in the development of PAH, has been identified.
Mathematical prediction model construction of network packet loss rate and nonlinear mapping user experience under the Internet of Things
Authors: Fan Bin , Nagaraj B. 
Published: September 2023

Abstract
In order to further improve the prediction accuracy, the network packet loss rate (PLR) prediction mathematical model based on the Internet of Things (IoTs) was proposed. First, the network data transmission module was established, and the network PLR prediction process was developed based on IoTs; second, the prediction framework of PLR was designed to obtain more accurate prior information. The relationship between PLR and user experience quality QoE is univariate and nonlinear. The mapping between PLR and user experience quality QoE is established using univariate nonlinear regression analysis; finally, a mathematical model of network PLR prediction is constructed to further improve the prediction accuracy. Experimental results show that the delays of network nodes are all within 5 s, which can ensure the real-time nature of data transmission. When the total number of packets and the number of lost packets are the same, the PLR predicted by the mathematical model designed by the authors is consistent with the actual PLR. Conclusion: The prediction effect of the model is better and has higher promotion value.
A review on complex turbulent dynamic phenomenon of natural vortex length in cyclone separator
Authors: Gao Zhuwei , Wei Yaodong , Liu Zhongxin 
Published: September 2023

Abstract
The natural vortex length is a complex turbulent dynamic phenomenon of cyclone separator, which can provide reference for the height design. It is calculated by the axial distance between the vortex end and the bottom of vortex finder. At present, scholars mainly attribute the influencing factors of natural vortex length to cylinder diameter, inlet area and vortex finder diameter, ignoring the influence of other structural parameters and operating parameters, so the accuracy and applicability of empirical formula are poor. This study described the mechanism of the vortex end and analyzed the PVC phenomenon. Then, an example was provided to illustrate the limitations and shortcomings of empirical formula. In addition, the influences of some geometric parameters and operating parameters on natural vortex length were summarized. Therefore, this work could provide an important reference for design optimization of cyclone separator height.
Scattering of low-energy Ne+ ions from the stepped surface of InGaP(001)<110> at the small angles of incidence
Authors: Kutliev U.O. , Otabaev M.U. , Karimov M.K. , Masharipov F.K. , Woiciechowski I. 
Published: September 2023

Scattering of Ne+ ions at small angles of incidence from a stepped InGaP(001) <110> surface by the E0=5 keV was simulated using computer simulation. The trajectories of dechanneled ions from defect surface, as well as their energies at the scattering and scattering angle, are studied. It is shown that before dechanneling, the frequency and amplitude of the trajectory of ions, which move the surface channel formed by the stepped atom, increase. The energy distributions of these ions are obtained and the part of the spectrum corresponding to these ions is determined. It has been established that the energetic dechanneled ions formed low intensity peaks on the low-energy part of the spectrum.
Ocurrencia y distribución de Bemisia tabaci y Trialeurodes vaporariorum (Hemiptera: Aleyrodidae) en cultivos de tomate en Panamá
Authors: Herrera Vasquez José Ángel , Jaén Sanjur José Natividad , Zachrisson Salamina Bruno Alexis , Rubio Miguélez Luis , Barba Alvarado Anovel Amet , Aguilera Cogley Vidal Antonio , Atencio Valdespino Randy , Galipienso Torregrosa Luis , Mejía Franco Luis Carlos 
Published: September 2023

Las principales regiones productoras de tomate a campo abierto y en invernadero en Panamá (provincias de Los Santos, Herrera, Veraguas y Chiriquí) fueron muestreadas para determinar la ocurrencia y distribución de Bemisia tabaci y Trialeurodes vaporariorum durante las temporadas de cultivo de 2017 y 2018. Se encuestaron veintidós parcelas y se analizaron extractos de ADN de 112 moscas blancas adultas mediante PCR múltiplex utilizando un conjunto de iniciadores específicos de B. tabaci MEAM1, B. tabaci NW y T. vaporariorum. De los extractos de ADN correspondientes a 57 moscas blancas individuales (50.9 %) se obtuvieron productos de PCR del tamaño esperado con iniciadores específicos de B. tabaci (37 pertenecían a B. tabaci MEAM1 y 20 a B. tabaci NW), mientras que de los extractos de ADN restantes correspondientes a 55 individuos de moscas blancas (49.1 %) se obtuvieron productos del tamaño esperado con iniciadores específicos de T. vaporariorum. La secuenciación de estos productos de PCR y el análisis BLAST permitieron la identificación de B. tabaci MEAM1, B. tabaci NW y T. vaporariorum. Bemisia tabaci NW se detectó en las cuatro provincias, mientras que B. tabaci MEAM1 se detectó en las provincias de Los Santos, Herrera y Chiriquí, y T. vaporariorum se detectó solamente en la provincia de Chiriquí. Bemisia tabaci MEAM1, B. tabaci NW y T. vaporariorum fueron detectadas en ambos sistemas de producción (campo abierto e invernadero). Bemisia tabaci MEAM1 y B. tabaci NW fueron detectadas en los climas de selva tropical (Af) y sabana tropical (Aw), en un rango altitudinal de 19–1543 metros sobre el nivel del mar (m s. n. m.), mientras que T. vaporariorum fue encontrada solamente en el clima Af, en un rango altitudinal de 818–1661 m. s. n. m. Según nuestro conocimiento, este no es solo el primer reporte de B. tabaci MEAM1 y B. tabaci NW a una altitud por encima de 1000 m. s. n. m. en Panamá, sino también es el primer reporte de T. vaporariorum a una altitud por debajo de 1000 m. s. n. m. en este país. La información sobre la identificación y distribución geográfica de las moscas blancas en Panamá ayudará a diseñar estrategias efectivas para el manejo de plagas.
SIMPL3: un lenguaje de programación para artistas y diseñadores en español
Authors: Cuartas Correa José David 
Published: September 2023

SIMPL3 es un lenguaje creado especialmente para no programadores en el que pueden escribir código haciendo uso de una sintaxis en español, a diferencia de lo que sucede con la mayoría de los lenguajes de programación que están en inglés. Este proyecto se fundamenta en un enfoque empírico analítico, basado en un prototipo rápido incremental, en el que primero se diseñan módulos aislados con funcionalidades básicas y luego se van agregando (módulo por módulo) a una implementación general que integra a todos los módulos. En este momento, el proyecto se encuentra en proceso de prueba y validación. Se viene desarrollando desde el año 2021 y es publicado bajo licencia software libre GPLv3; es multiplataforma, lo que permite ser ejecutado tanto en Windows, como en Linux o en MacOS. Este es uno de los proyectos desarrollados dentro del laboratorio Inmedia, en la Universidad del Valle, Cali, Colombia, y puede ser descargado de: https://sourceforge.net/projects/simpl3/files/
Conciencia aural del conflicto. Práctica de escucha y recreación sonora en el proyecto Llamado de Guerra
Authors: Ferro Astaiza Esteban Camilo 
Published: September 2023

En los últimos cincuenta años, la vivencia de conflictos locales a través de los medios de comunicación ha sido una experiencia común a las distintas sociedades latinoamericanas. Durante guerras civiles, dictaduras y revueltas sociales, la radio fue utilizada para imponer narrativas sobre los sucesos y formar una opinión uniforme en las audiencias. La radio, como medio de comunicación arraigado a la población latinoamericana, fue utilizada de formas particulares en cada territorio, pero con operaciones similares debido a las relaciones geopolíticas e históricas de los Estados-nación resultantes de tres siglos de colonización. Llamado de Guerra es una investigación que busca indagar cómo fue utilizada la radiodifusión durante los conflictos en Latinoamérica, a partir del desarrollo de una práctica artística fundamentada en la escucha y recreación de un archivo sonoro de documentos relacionados con acontecimientos políticos donde la radiodifusión fungió un papel crucial en el desarrollo de un conflicto. En este texto expondré aspectos de esta práctica en relación con la dominación territorial por medio del sonido, la reproducción de la realidad a través de los medios de comunicación, las prácticas de escucha profunda y la memoria histórica.
Statistical model based on climatological variables for the prediction of pest and disease incidence in rose (Rosa spp.) crops
Authors: Lombana-Peña William Alberto , Pedraza-Contreras Oscar Eduardo , Ordoñez-Córdoba Ramiro , Nova Manosalva Omar Ariel , Salamanca Bernal Julián Andrés 
Published: September 2023

In Colombia, floriculture is a very important section of the economy since it provides income to the country. Within this sector is the cultivation of roses (Rosa spp.), whose production and quality are affected by the presence of various pests and diseases. Among these pests are thrips Frankliniella occidentalis and mites Tetranychus urticae, and among the diseases are downy mildew Peronospora sparsa, powdery mildew Podosphaera pannosa and botrytis Botrytis cinerea. This problem generates large expenses in the purchase of agrochemical products for their control and management. This study analyzes the incidence of various pests and diseases in rose cultivation as a function of climatological variables (evaporation, temperature, relative humidity, and precipitation) in order to predict a future affectation. The analysis was carried out with R as programming language for the calculation of a multiple linear regression model. The results showed satisfactory prediction for the percentage incidence of each of the pests and diseases, since the difference between the predicted values and the values obtained by monitoring did not exceed 5% for the downy mildew, botrytis, mites, and thrips and 10% for the powdery mildew. The tool presented shows appropriate prediction for the possible behavior of the pests and diseases, and, thus, provides the opportunity to counteract their damage and estimate the investment required for their control. In this study, only the percentage incidence data of each of the pests and/or diseases was considered, as well as the value of the response variables in percentage incidence.
Leche materna deslactosada con la enzima beta galactosidasa para lactantes intolerantes
Authors: Lopez Marin Beatriz Lopez , Catillejo Padilla Nelly Patricia , Restrepo Betancur Luis Fernando 
Published: September 2023

Introducción: los bebés deben beneficiarse de la leche materna, incluso cuando presentan intolerancia a la lactosa. Por esto, se debe recurrir a la obtención de leche materna deslactosada.
Objetivo: analizar el efecto de la enzima beta galactosidasa en la hidrólisis de la lactosa de leche materna madura para bebés clínicamente diagnosticados con intolerancia a la lactosa.
Materiales y método: estudio exploratorio, descriptivo y explicativo. El contenido de lactosa se cuantificó desde el inicio hasta el final del tratamiento, controlando temperatura, tiempos y cantidad de enzima ß-galactosidasa adicionada en la leche materna. Se recolectaron 1.000 ml de leche materna, obtenidos del Banco de Leche del Hospital General de Medellín (Antioquia, Colombia).
Resultados: las muestras donadas se encontraban pasteurizadas y posteriormente fueron sometidas a la acción de la enzima lactasa. Se cuantificó el contenido de lactosa sin la enzima, reportando en promedio 6,34 mg/100 ml ± 0,23. El mayor aporte de lactosa obtenido posterior a la exposición a la enzima (30 minutos) fue de 6,07 mg/ml ± 0,35 (correspondiente a 95 % del contenido inicial), finalizando con un aporte de 0,35 % a una concentración de 0,4 % tras 24 horas, porcentaje que representa 95 % de la hidrólisis total en la leche materna.
Conclusiones: en todas las muestras analizadas de diferentes madres se pudo obtener leche materna con bajas concentraciones de lactosa tras 24 horas de haber sido sometidas a la acción de ß-galactosidasa. Lo anterior se establece como una alternativa para los bebés intolerantes a la lactosa, que permitiría no privarlos de todos los beneficios que ofrece este alimento.
Multiscale interdependence between economic policy uncertainty and industrial production of Central and Eastern European countries
Authors: Živkov Dejan , Manić Slavica , Đurašković Jasmina , Momčilović Mirela 
Published: September 2023

AbstractThis paper shows how the three economic policy uncertainties (EPUs), namely global economic uncertainty, US economic policy uncertainty and German economic policy uncertainty, impact the industrial production of 8 Central and Eastern European countries. The investigation is done in both time and frequency domains, using the wavelet coherence and wavelet correlation approaches. The US EPU has the strongest effect on all industrial productions, while this effect was recorded during the global financial crisis and the corona virus pandemic. The most intense effect was found in the time-horizon between 4 and 8 months. The Czech Republic and Hungary suffer the strongest impact from EPU, probably because these two economies have relatively high ratio of export (import) vis-à-vis GDP. We fail to find very strong and wide areas of coherence in the Slovakian plot, although Slovakia has the highest level of export (import) to GDP. However, the wavelet correlation findings indicate that Slovakia has relatively high negative correlation at third wavelet scale, which is perfectly in compliance with its high export (import) share in GDP.
Determinants of advertising expenditures: Role of stock prices in an emerging market
Authors: Farooq Omar , Ahmed Neveen 
Published: September 2023

AbstractThis paper documents the relationship between advertising expenditures and stock prices. Using the data of non-financial firms from India, the paper shows that advertising expenditures of a firm are sensitive to its own stock prices and to stock prices of its peer firms during the period between 2000 and 2021. These findings remain qualitatively the same when we use different estimation procedures. The paper also shows that the relationship between advertising expenditures and stock prices depends on the level of product market competition. This relationship becomes more pronounced as product competition increases.
Dominant barriers in accessing modern health care services among vulnerable community in central India: An explicit observation
Authors: Kumar Dinesh Kumar , Sharma Shweta , Singh Taranand , Banjarey Pooja , Saini Sandhy , Saxena Nishant 
Published: September 2023

The study aimed to identify barriers/impediments in accessing health care facilities in vulnerable tribal community. A community-based cross-sectional observation on health service utilization was carried out among the vulnerable Saharia tribe in Sheopur district of Madhya Pradesh. The data was gathered by skilled investigators from influencing community members during August to October 2020. Relevant information’s was collected from 212 respondents from 40 villages. Out of 40 village, 16(40%) of which were health facility villages located &#60;5 km radius of health centers i.e. PHCs, SHCs and HWCs, and 24(60%) from non-health facility villages located &#62;5 km radius of any of these health centers.The study found that three common barriers emerged; majorly as lack of awareness, misconception of child immunization and inadequate behavior of health care workers in both health facility village (located&#60;5 km radius of health centers) and non-health facility village(located&#62;5 km radius of health centers). Further, these barriers are considerably affected in non-health facility village along with the public transportation facility and poor road conditions (45.3%) in comparison to health facility villages’ (32.1%).Identified barriers in accessing health care facility is more startling in non-health facility villages as compared to health facility villages. These explored barriers need to be minimized through effective implementation research and strategy among vulnerable community in favor of achieving universal health coverage (UHC) particular in rural and remote regions.
To study the impact of screen time on IT job professionals in India
Authors: Rajesh Kumar N , Jain Shreya , Bhargava Lakshita 
Published: September 2023

This study aims to understand more about the effects of screen time on the eyes, musculoskeletal problems, and work efficiency in IT professionals. Problems faced by the people and the measures taken to solve them: A questionnaire was designed and distributed among IT professionals. Respondents discussed their issues regarding their eyes, musculoskeletal problems, and efficiency at work. Furthermore, respondents were asked if they and their organizations were taking any measures to deal with the issues due to the excessive effects of screen time. Insights were also drawn on how they can improve the current working system to deal with the impact of screen time. These insights were represented in the form of a word chart. In conclusion, a significant percentage of the population faces screen-related problems, but many people are not taking any measures to deal with them. Organizations and employees alike are advised to take these problems seriously and start implementing their solutions as soon as possible.
COMPROMETIMENTO: UM ESTUDO DO COMPORTAMENTO ORGANIZACIONAL DENTRO DE UMA ESCOLA PÚBLICA
Authors: Da Silva Josinaldo Oliveira , Napomuceno Fontinelli Aniuska Almeida 
Published: September 2023

<p>Resumo</p><p>As condutas individuais e coletivas de líderes e colaboradores implicam no ambiente de trabalho quanto aos benefícios para a organização, uma vez que, o comportamento organizacional envolve tudo aquilo que é necessário para que o ambiente de trabalho seja harmonioso e que o colaborador tenha tranquilidade e segurança para a realização de suas atividades. Assim, partindo desta premissa, o presente trabalho se propõe a analisar as questões referentes as medidas de comprometimento nas organizações, como validação e precisão, na dinâmica organizacional relacionada à gestão de pessoas uma vez que, os resultados dos estudos acadêmicos de certo modo são utilizados como ferramentas voltadas para o diagnóstico que pretendem avaliar a relação existente entre o servidor e a organização. O objetivo deste estudo é justamente analisar e mensurar o comprometimento destes indivíduos com a organização onde atuam, tendo como objeto de pesquisa a Escola Municipal de Ensino Fundamental Manoel Soares de Oliveira localizada no Sítio Lagoa de Fora – Área Rural, na cidade de Itapororoca-PB, através da pesquisa exploratória, bibliográfica e descritiva. Que após a análise dos resultados e dados coletados chega-se à conclusão de que o perfil em que mais se encaixam os servidores desta instituição o comprometimento instrumental onde cada servidor tem sua necessidade específica de permanecer na organização, seja por motivos de custos associados a sua saída ou por necessidade de permanência por outros motivos.</p><p> </p><p>Palavras-chave: Comprometimento organizacional; Instrumental; Necessidade; Servidor.</p>
WORKING IN THE DIGITAL EDUCATIONAL ENVIRONMENT: PROS AND CONS
Authors: Opareniuk Iryna 
Published: September 2023

Using the capabilities of the digital educational environment for students is one of the key forms of obtaining quality education and self-realization, and for teachers – a way to improve their professional skills in creating interesting classes and developing methodological materials. With the help of digital environment, a teacher can work effectively online, prepare interactive classes for students on various online platforms, improve their pedagogical skills by participating in competitions, webinars, conferences and trainings. Students can view classes online, use various resources for online learning, create projects using modern educational technologies and engage in self-education. However, working in the digital educational environment has many risks and dangers that can significantly worsen a person's emotional state and lead to material losses.
ПРОБЛЕМАТИКА СУТНОСТІ ТА ЗАСОБІВ ЗАБЕЗПЕЧЕННЯ ПРАВОВОЇ ОСВІТИ НАСЕЛЕННЯ
Authors: Древаль Юрій Дмитрович 
Published: September 2023

Розглянуто питання щодо сутності та особливостей забезпечення правової освіти населення. Додатково обґрунтовано положення про те, що досягнення кінцевого результату у вигляді належної правової освіченості громадян та соціуму в цілому має ґрунтуватися на поєднаних зусиллях усіх учасників освітянського процесу. Робиться висновок, що важливе значення має відводитися усвідомленому відношенню до процесу набуття та засвоєння правових знань самими громадянами.
ПСИХОЛОГО-ПЕДАГОГІЧНІ АСПЕКТИ НАВЧАННЯ СТУДЕНТІВ В УМОВАХ МОДЕРНІЗАЦІЇЇ ВИЩОЇ ОСВІТИ І ЗАСТОСУВАННЯ ДИСТАНЦІЙНИХ ТЕХНОЛОГІЙ
Authors: Говорун Тетяна , Білоус Олена , Берладір Христина , Ханюков Kирило , Варакін Варакін 
Published: September 2023

У статті проводиться аналіз психолого-педагогічних закономірностей засвоєння знань та здобуття навичок студентами у рамках двох систем навчання. Перша система, що розглядається - це система організації навчання, під час якого викладач приймає безпосередньо участь майже в усіх етапах формування та засвоєння знань. Друга – кредитно-модульна система, яка передбачає багато самостійної роботи студентів і надає можливість застосування дистанційних технологій навчання. У роботі зроблений аналіз переваг та недоліків цих двох систем навчання у вищій школі. Автори бачать ефективність сучасної освіти у поєднанні деяких аспектів цих двох систем.
ЗМІНА ПАРАДИГМИ ОСВІТИ ДОРОСЛИХ ТА ЇЇ ВІДОБРАЖЕННЯ У РОЗВИТКУ АНДРАГОГІКИ ЯК НАУКИ
Authors: Матульчік Юліус 
Published: September 2023

У статті розглянуто результати теоретичного аналізу існуючих змін парадигми освіти дорослих та їх відображення у розвитку андрагогіки як науки. Викладено особливості освіти дорослих як чинника розвитку суспільства в умовах глобалізаційних та євроінтеграційних процесів, а також встановлено, що провідною метою освіти і навчання впродовж життя було і залишається зосередження на всебічному розвитку дорослої людини.