bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionally analogous body- and animacy-responsive areas are present in the dog (Canis familiaris) and human occipito-temporal lobe
Authors: Boch Magdalena , Wagner Isabella C. , Karl Sabrina , Huber Ludwig , Lamm Claus 
Published: June 2023

AbstractComparing the neural correlates of socio-cognitive skills across species provides insights into the evolution of the social brain and has revealed face- and body-sensitive regions in the primate temporal lobe. Although from a different lineage, dogs share convergent visuo-cognitive skills with humans and a temporal lobe which evolved independently in carnivorans. We investigated the neural correlates of face and body perception in dogs (N = 15) and humans (N = 40) using functional MRI. Combining univariate and multivariate analysis approaches, we found functionally analogous occipito-temporal regions involved in the perception of animate entities and bodies in both species and face-sensitive regions in humans. Though unpredicted, we also observed neural representations of faces compared to inanimate objects, and dog compared to human bodies in dog olfactory regions. These findings shed light on the evolutionary foundations of human and dog social cognition and the predominant role of the temporal lobe.
Anomalous fractal scaling in two-dimensional electric networks
Authors: Zhang Xiao , Zhang Boxue , Sahin Haydar , Siu Zhuo Bin , Rafi-Ul-Islam S. M. , Kong Jian Feng , Shen Bing , Jalil Mansoor B. A. , Thomale Ronny , Lee Ching Hua 
Published: June 2023

AbstractMuch of the qualitative nature of physical systems can be predicted from the way it scales with system size. Contrary to the continuum expectation, we observe a profound deviation from logarithmic scaling in the impedance of a two-dimensional LC circuit network. We find this anomalous impedance contribution to sensitively depend on the number of nodes N in a curious erratic manner and experimentally demonstrate its robustness against perturbations from the contact and parasitic impedance of individual components. This impedance anomaly is traced back to a generalized resonance condition reminiscent of Harper’s equation for electronic lattice transport in a magnetic field, even though our circuit network does not involve magnetic translation symmetry. It exhibits an emergent fractal parametric structure of anomalous impedance peaks for different N that cannot be reconciled with a continuum theory and does not correspond to regular waveguide resonant behavior. This anomalous fractal scaling extends to the transport properties of generic systems described by a network Laplacian whenever a resonance frequency scale is simultaneously present.
Expression and prognostic role of STAT5a across cancer types
Authors: Maninang Christine , Li Jinghong , Li Willis X. 
Published: June 2023

Abstract
Studies examining the role of signal transducer and activator of transcription 5 (STAT5) in various cancers have produced controversial results. To address this controversy, we examined the prognostic role of STAT5a in cancer patients across multiple cancers. Transcription levels of STAT5a between tumors and normal tissues, obtained from public databases, were analyzed for statistical differences using Cox regression analysis with the outcome as overall survival and covariate of interest as high STAT5a expression. Meta-analysis was then conducted to summarize the hazard ratio estimate from the Cox regression analyses. We found that STAT5a was significantly under-expressed in breast, lung, and ovarian cancers, while STAT5a was significantly overexpressed in lymphoid neoplasm diffuse large B-cell lymphoma, glioblastoma, and glioma. High STAT5a expression was significantly associated with favorable survival in bladder cancer (lnHR = −0.8689 [−1.4087, −0.3292], P-value = 0.0016), breast cancer (lnHR = −0.7805 [−1.1394, −0.4215], P-value &lt; 0.0001) and lung cancer (lnHR = −0.3255 [−0.6427, −0.0083], P-value = 0.0443). After adjusting for clinicopathological factors, high STAT5a expression remained significantly associated with favorable survival in breast cancer (lnHR = −0.6091 [−1.0810, −0.1372], P-value = 0.0114). These results suggest that higher STAT5a expression is associated with favorable overall survival in breast cancer, and therefore might have protective effects, and that STAT5a expression could be a potential prognostic biomarker, especially in breast cancer. However, the prognostic role of STAT5a is dependent on cancer type.
Tolerable random interruption duration based reliability estimation of stand alone hybrid renewable energy system by network reduction and sequential Monte Carlo simulation
Authors: Koshti Atul S. , Verma Aanchal , Arya Rajesh , Roy Chandrima , Arya Liladhar , Choube Sharat Chandra , Khan Baseem 
Published: June 2023

AbstractThis paper presents a novel tolerable random interruption duration (TRID) concept for estimation of reliability indices of stand‐alone hybrid renewable energy system (SAHRES) during down time. This concept utilizes the ignorance of interruption duration if it is tolerable in event of failure. It uses a framework using network reduction technique and sequential Monte Carlo simulation (SMCS) suitable for present research whereas the solution in such cases is not feasible with analytical method. Thus reliability indices such as mean up time, mean down time, failure frequency, system failure rate, interruption duration and system unavailability are estimated using SMCS. Modelling aspects are considered for load, capacity, renewable energy system and TRID due to network outage. The impact of considering random tolerable interruption duration has been demonstrated on the reliability indices and case study is presented to show the effect of change of TRID on reliability indices. A sample SAHRES has been considered for the study.
Disentangling UV photodesorption and photoconversion rates of H2O ice at 20 K
Authors: Bulak M. , Paardekooper D. M. , Fedoseev G. , Samarth P. , Linnartz H. 
Published: June 2023

Context. The nondissociative ultraviolet photodesorption of water ice is a nonthermal desorption mechanism required to account for detected abundances of gas-phase water toward cold regions within the interstellar medium. Previous experimental and theoretical studies provide a range of photodesorption rates for H2O ice and point to a convoluted competition with other molecular processes following the absorption of a UV photon in the ice. Ultraviolet irradiation also induces photodissociation, resulting in the formation of radicals that may directly desorb triggering gas-phase reactions or recombine in surface reactions.
Aims. In this work, we aim to quantify the effects of photodesorption and investigate photoconversion upon UV photolysis of an H2O ice.
Methods. We irradiated a porous amorphous H2O ice at 20 K with UV photons in the 7–10.2 eV range and compared the measurements to a nearly identical experiment that included a layer of argon coating on top of the water ice. The purpose of the argon coating is to quench any type of photon-triggered desorption. To trace ice composition and thickness, laser desorption post ionization time-of-flight mass spectrometry was utilized. This method is independent of the (non)dissociative character of a process and provides a diagnostic tool different from earlier studies that allows an independent check.
Results. The total photodesorption rate for a porous amorphous H2O ice at 20 K we derive is (1.0 ± 0.2) × 10−3 per incident UV photon (7–10.2 eV), which is in agreement with the available literature. This rate is based on the elemental balance of oxygen-bearing species. As a result, we placed an upper limit on the intact (H2O) and dissociative (OH) desorption rates equal to 1.0 × 10−3 per incident UV photon, while for the reactive desorption (O2), this limit is equal to 0.5 × 10−3 per incident UV photon. Photoconversion depletes the H2O ice at a rate of (2.3 ± 0.2) × 10−3 per incident UV photon. At low UV fluence (9.0 × 1017 photons cm−2), the loss of H2O is balanced by photoproduct formation (O2 and H2O2). At high UV fluence (4.5 × 1018 photons cm−2), about 50% of the initial H2O molecules are depleted. This amount is not matched by the registered O-bearing products, which points to an additional, unaccounted loss channel of H2O.
Veno-arterial extracorporeal membrane oxygenation for post-infarction ventricular septal defect in a low-volume center
Authors: Antonic Miha , Djordjevic Anze , Podlesnikar Tomaz , Pirnat Maja , Robic Boris , Petrovic Rene , Gregoric Igor D. 
Published: June 2023

Managing patients with post-ischaemic ventricular septal defects (VSD) and postcardiotomy cardiogenic shock can be extremely challenging in a low-volume cardiac surgery unit. We present a case of a 68-year-old patient who received veno-arterial extracorporeal membrane oxygenation support due to cardiogenic shock after VSD repair. The patient was successfully weaned off support after 86 h. In the postoperative period, mediastinitis occurred, and negative pressure wound therapy was instituted.
Stellte der Einsatz von Cytotec in der Geburtshilfe an sich einen
Behandlungsfehler dar?
Authors: Brocks Johannes , Uphoff Roland 
Published: June 2023

ZusammenfassungDer off-label-use des Medikaments Cytotec (Wirkstoff: Misoprostol) des
Herstellers Pfizer ist in Deutschland zur Geburtseinleitung weit verbreitet
gewesen. Diese Praxis war und ist rechtlich umstritten. Sie beschäftigt
zurzeit eine Vielzahl von Gerichten. In diesem Aufsatz wird der Frage
nachgegangen, ob der off-label-use von Cytotec bis zum Markteintritt von Angusta
im Jahr 2021 mit dem geschuldeten ärztlichen Standard vereinbar war,
oder ob der Einsatz per se einen Behandlungsfehler darstellte. Die Autoren sind
zu dieser Frage von der Deutschen Gesellschaft für Perinatale Medizin
(DGPM) mit der Erstellung eines Rechtsgutachtens beauftragt worden. Das
vollständige Gutachten kann von Mitgliedern der DGPM eingesehen und in
forensischen Auseinandersetzungen verwendet werden.
Amplitude-Integrated Electroencephalography Evolution and Magnetic Resonance Imaging Injury in Mild and Moderate to Severe Neonatal Encephalopathy
Authors: Sakpichaisakul Kullasate , El-Dib Mohamed , Munster Chelsea , Supapannachart Krittin J. , Yang Edward , Walsh Brain H. , Volpe Joseph J. , Inder Terrie E. 
Published: June 2023

Objective This study aimed to describe the evolution of amplitude-integrated electroencephalography (aEEG) in neonatal encephalopathy (NE) during therapeutic hypothermia (TH) and evaluate the association between aEEG parameters and magnetic resonance imaging (MRI) injury.
Study Design aEEG data of infants who underwent TH were reviewed for background, sleep wake cycling (SWC), and seizures. Conventional electroencephalography (cEEG) background was assessed from the reports. Discordance of background on aEEG and cEEG was defined if there was a difference in the severity of the background. MRI injury (total score ≥ 5) was assessed by using the Weeke scoring system.
Results A total of 46 infants were included; 23 (50%) with mild NE and 23 (50%) with moderate to severe NE. Comparing mild NE with moderate to severe NE, the initial aEEG background differed with more mild being continuous (70 vs. 52%), with fewer being discontinuous (0 vs. 22%) and flat tracing (0 vs. 4%), whereas burst suppression (4 vs. 4%) and low voltage (26 vs. 18%) did not differ. There was a notably common discordance between the background assessment on cEEG with aEEG in 82% with continuous and 40% low voltage aEEG background. MRI abnormalities were identified in four infants with mild NE and seven infants with moderate to severe NE. MRI injury was associated with aEEG seizures in infants with moderate to severe NE.
Conclusion aEEG seizures are useful to predict MRI injury in moderate to severe NE infants. There is a large discrepancy between aEEG, cEEG, and MRI in neonates treated by TH.
Key Points
Reintubation Rate between Nasal High-Frequency Oscillatory Ventilation versus Synchronized Nasal Intermittent Positive Pressure Ventilation in Neonates: A Parallel Randomized Controlled Trial
Authors: Phatigomet Manapat , Thatrimontrichai Anucha , Maneenil Gunlawadee , Dissaneevate Supaporn , Janjindamai Waricha 
Published: June 2023

Objective Nasal high-frequency oscillatory ventilation (nHFOV) and synchronized nasal intermittent positive pressure ventilation (sNIPPV) were the new modes of noninvasive ventilation. This study's aim was to clarify as to which of the nHFOV and sNIPPV modes was superior in preventing postextubation failure or reintubation in neonates.
Study Design An open-label parallel randomized study was performed. Extubated preterm and term neonates were randomly allocated into nHFOV or sNIPPV modes; the reintubation rate was evaluated within 7 days after extubation between the two modes. Subgroup analyses were performed for preterm (gestational age <37 weeks) and very preterm (gestational age <32 weeks) neonates. The sample calculation was 1,050 neonates; however, this trial was stopped early as enrollment was too slow.
Results From July 2020 to June 2022, 202 neonates were assessed for eligibility and 69 neonates were excluded. Finally, 133 neonates were randomly allocated to the study interventions (nHFOV = 67, sNIPPV = 66). The median gestational age and birth weight were 33 (30–37) weeks and 1,910 (1,355–2,836) g, respectively. The reintubation rate within 7 days did not significantly differ between the groups (nHFOV [5/67, 7%] vs. sNIPPV [4/66, 6%]); risk difference [95% confidence interval] = 0.01 [−0.08 to 0.11]; p = 0.99), including preterm (nHFOV [4/55, 7%] vs. sNIPPV [3/44, 7%]) and very preterm (nHFOV [3/25, 12%] vs. sNIPPV [3/25, 12%]) neonates.
Conclusion After neonatal extubation, there was no significant difference of reintubation rates within 7 days between nHFOV and sNIPPV. This trial has been registered in the ClinicalTrials.gov database (
https://clinicaltrials.gov/ct2/show/NCT04323397
). First posted registration on March 26, 2020.
Key Points
Boryl Radical-Promoted Deoxygenative Alkylation of Benzyl Acetates
Authors: Zhang Feng-Lian , Wang Yi-Feng , Liu Nan-Nan , Wan Xuan-Chen , Hui Li-Wen 
Published: June 2023

AbstractDeoxygenative alkylation of benzyl alcohols was realized by using acetate as the alcohol activation group. The C–O bond homolysis is achieved by a boryl radical-promoted β-scission process. The strategy is amenable to a variety of benzyl alcohols, including primary, secondary, and more challenging tertiary alcohols. The synthetic practicability was demonstrated by a gram-scale one-pot reaction.
Efficient Synthesis of Aminoquinolinium and Aminoquinazolinium Salt Series: Amination or N-Alkylation First?
Authors: Casanova Marion C. , Fil Maximilien , Vanelle Patrice , Broggi Julie , Zhao Yuxi , Azas Nadine , Redon Sébastien 
Published: June 2023

AbstractThe pharmacokinetic properties and, in particular, the poor solubilities of lead drug compounds are often a major impediment to their future clinical development. One common and effective solution is generally to use salt forms. Efficient strategies for the synthesis of quinolinium and quinazolinium salt series with promising therapeutic activities are thus of major interest. This study compares different synthetic routes for the rapid preparation of monomeric and dimeric aminoquinolinium and aminoquinazolinium salts. The advantages and limitations of the different processes, especially the importance of step order, are discussed.
Neurocognitive Profile and 18F-Fluorodeoxyglucose Positron Emission Tomography Brain Imaging Correlation in Children with Electrical Status Epilepticus during Sleep
Authors: Srivastava Madhur K. , Shaik Afshan J. , Yareeda Sireesha , Nallapareddy Kavitha , Lingappa Lokesh , Moturi Pallavi , Gaddamonugu Padmaja , Kandadai Rukmini M. , Borgohain Rupam 
Published: June 2023

AbstractObjective Electrical status epilepticus in sleep (ESES) is defined by near-continuous epileptiform discharges during sleep along with cognitive, behavioral, and/or imaging abnormalities. We studied the neurocognitive profile and their correlation with 18F fluorodeoxyglucose positron emission tomography (FDG PET) brain abnormalities in children with ESES.Methods Fourteen children with ESES with normal magnetic resonance imaging (MRI) from March to December 2019 were included. The intelligence quotient (IQ) and child behavior checklist (CBCL) scores were estimated using validated scales, and FDG PET brain was done at the same point of time to look for cerebral metabolic defects which was compared with a control group.Results Fourteen patients with a mean age of 8.2 ± 2.7 years were analyzed. The average duration of epilepsy was 6 ± 2.8 years. The mean IQ was 72.4 ± 18.2 and mean CBCL score was 37.3 ± 11.8. There was negative correlation between IQ and CBCL (r = −0.55, p < 0.001). The duration of epilepsy also showed negative correlation with IQ (r = −4.75, p < 0.001). FDG PET scan showed predominant thalamic hypometabolism in 12 of 14 patients (85.7%) on visual analysis with multiple other hypometabolic cortical and subcortical regions in the brain. The quantitative analysis showed significant difference in metabolism of basal ganglion when compared with control group. The total number of hypometabolic regions seen in the brain showed moderate positive correlation with CBCL score but no significant correlation with the IQ of cases.Conclusion This study demonstrates functional impairment of cerebral cortical, basal ganglia, and thalamic hypometabolism in a cohort of ESES patients with normal structural MRI brain study. There was a moderate correlation of extent and pattern of cerebral hypometabolism with the neuropsychological status of the child and duration of epilepsy.
Single-Center Experience Using the Inari FlowTriever for Mechanical Thrombectomy of Extrapulmonary Thrombosis: A Case Series
Authors: Patel Achintya , Weekley Adam , Goloubev Alexey , Markovitz Michael , Hoots Glenn 
Published: June 2023

AbstractThe FlowTriever Gen 1 System (Inari Medical, Irvine, California, United States) is a mechanical thrombectomy device designed to extract thrombus from the pulmonary arteries, but is U.S. Food and Drug Administration approved for use in any artery or vein. From 2019 to 2020, three consecutive patients with extrapulmonary thrombosis involving the inferior vena cava (IVC), renal, gonadal, and femoropopliteal veins were treated with the device. The FlowTriever large-bore aspiration catheter was partially successful in removing IVC, renal and lower extremity vein thrombus. Zero major or minor adverse events occurred. Several technical and therapeutic insights were gained from this preliminary experience.
Optimal cancer care pathways – the ideal versus reality for patient-centric cancer care during COVID-19
Authors: Samaranayake Shanuka , Barker Daniel , Windsor Apsara 
Published: June 2023

Objectives To assess whether compliance with the nationally endorsed Optimal Care Pathways is evident in 75% of patients treated with curative intent treatment and if this compliance was impacted by the COVID-19 pandemic (hereinafter COVID-19). Methods This retrospective study included patients undergoing curative treatment with radiotherapy in head and neck (HN), breast, lung and gastrointestinal malignancies between January 2019 and June 2021 in a single NSW outer metropolitan cancer service. For care delivered within the remit of cancer services, the primary outcome measure was the proportion of patients whose treatment complied with the Optimal Care Pathways recommended time frame. Secondary outcome measures included evaluating the effect of COVID-19 on the proportion of patients being treated within the recommended time frame. Results There were n = 733 eligible patients across the five tumour streams with the majority being breast cancer patients comprising 65% (n = 479) of the cohort, followed by HN cancer patients (n = 125, 17%). None of the tumour subsites abided by the 75% compliance rate. Oesophageal cancer patients had the lowest compliance rate of 4% (P < 0.001), with a similarly low compliance rate for rectal cancer patients at 33% (P = 0.002). None of the hypothesis tests to assess for detriment in treatment time during COVID-19 were statistically significant (P > 0.05). Conclusion Despite the availability of best practice guidelines, there is limited compliance throughout all cancer subtypes, which has not been negatively influenced by COVID-19. Improved awareness of the Optimal Care Pathways, and implementation of the associated infrastructure and systems, are required to support compliance.
Cuanto(s) más datos, (tanto) mejor
Authors: Horsch Jakob 
Published: June 2023

Abstract
The Spanish comparative correlative (CC) construction (Cuanto más leo, (tanto)
más entiendo) has a complex syntactic structure and complex semantics. The syntactic relationship between its
two subclauses has been subject to much debate. This study, the first large-scale (> 3,000 tokens) corpus investigation,
explores various aspects and provides evidence for hypotaxis. However, statistical analysis of the data also revealed
‘under-the-surface’ parataxis. I therefore argue that the construction cannot be classified as either hypotactic or paratactic,
but as hypotactic and paratactic to certain degrees, also compared with its counterparts in English and Slovak. I argue that the
‘competition’ between hypotactic and paratactic encoding can be attributed to the principle of iconicity, that is, the “(partial)
motivation of a construction’s form by its meaning” (Hoffmann, 2019, p. 12). Finally, I
discuss various formal aspects of the Spanish CC construction that have so far gone unnoticed, providing new evidence in the form
of corpus data.
ArchEnemy: removing scattered-light glitches from gravitational wave data
Authors: Tolley Arthur E , Cabourn Davies Gareth S , Harry Ian W , Lundgren Andrew P 
Published: June 2023

Abstract
Data recorded by gravitational wave detectors includes many non-astrophysical transient noise bursts, the most common of which is caused by scattered-light within the detectors. These so-called ‘glitches’ in the data impact the ability to both observe and characterize incoming gravitational wave signals. In this work we use a scattered-light glitch waveform model to identify and characterize scattered-light glitches in a representative stretch of gravitational wave data. We identify 2749 scattered-light glitches in 5.96 days of LIGO-Hanford data and 1306 glitches in 5.93 days of LIGO-Livingston data taken from the third LIGO-Virgo observing run. By subtracting identified scattered-light glitches we demonstrate an increase in the sensitive volume of a gravitational wave search for binary black hole signals by

∼

1
%

.