bluuebunny/crossref_metadata_2025_split huggingface dataset:
“La notte” di Dino Campana e Faust: tra metamorfosi e iniziazione
Authors: Tognocchi Luca 
Published: January 2023

Questo articolo indaga il tema della notte e la funzione poetica del personaggio di Faust all’interno delle prime sezioni dei Canti Orfici (“La Notte” e i “Notturni”) di Dino Campana. Campana dichiarò di voler fare del suo libro un “piccolo Faust,” e nomina proprio Faust come io-lirico della “Notte.” Inoltre, sono presenti espliciti richiami testuali alla scena “Notte di Valpurga” della tragedia goethiana, parzialmente tradotta da Campana in una lettera del settembre 1917.
In entrambe le opere, la notte permette la violazione dello status quo e consente all’io di valicare i propri confini. Se il notturno faustiano presenta continue metamorfosi e/o travestimenti dei personaggi in scena e include un rituale d’iniziazione cui lo stesso Faust prende parte, la notte campaniana diventa luogo e momento di trasformazione, secondo modalità carnevalesche, e di iniziazione ai culti misterici, che verranno studiate e approfondite nell’articolo.
Discourse and Intercourse
Authors: Fein Sarah 
Published: January 2023

In this article, I consider three narratives, Genesis 38, 2 Samuel 13, and Judges 19, in which biblical authors deploy women’s speech at moments of crisis in the plot. These moments are caused by women’s precarious location in the bêt ʾāb, which I theorize using the framework of the Patrimonial Household Model (PHM). I assess the women characters’ speech through the lens of Laura Mary Elizabeth Hare’s sociolinguistic analysis of gendered speech in biblical narrative. While Tamar in Gen 38 uses manipulation and “masculine” speech to successfully re-insert herself into the bêt ʾāb, Tamar in 2 Sam 13 is the victim of men’s manipulation and her “feminine” speech fails to protect her. The secondary wife in Judges 19 has no verbal speech, only speech-acts, which leaves her almost but not entirely at the mercy of men’s discourse. I argue that the biblical authors understood women characters as able to exercise some amount of agency through their leveraging of normatively masculine speech, but only for the purpose of re-establishing the social order of the PHM.
Sparse regression with clustered predictors
Authors: Kenny Aiden , Solomon Danielle , Patwary Mohammad S A , Das Kumer P 
Published: February 2023

Gene expression data can be challenging to analyze due to its high-dimensional nature. Regularization techniques are useful in reducing the number of predictors and highlighting the signiﬁcant genes, in this case, genes that may indicate the presence of cancer. This study aims to see if grouping the genes before applying the regularization techniques is beneﬁcial in reducing the prediction error of classiﬁcation. We investigate the potential effectiveness of using clustering algorithms to generate a grouping structure for high-dimensional data sets. Using various regularization techniques, we seek to determine if the generated groups are truly relevant to the response and if the accuracy and interpretability of the models can be improved. We apply the clustered group structure to two real-world data sets. We also employ simulation studies to assess the performance of different regularization methods for both clustering and no-clustering methods.
Journal of Statistical Research 2022, Vol. 56, No. 1, pp. 37-53
PENGARUH PENGGUNAAN APLIKASI QUIZIZZ TERHADAP HASIL BELAJAR SISWA KELAS IV SEKOLAH DASAR
Authors: Maharani Fitri , Erlisnawati  , Alpusari Mahmud 
Published: January 2023

Tujuan penelitian ini adalah untuk melihat efektivitas penggunaan aplikasi Quizizz terhadap hasil belajar siswa kelas IV Sekolah Dasar. Pada penelitian ini jenis pendekatan yang digunakan adalah kuantitatif dengan metode eksperimen. Bentuk penelitian ini Pre Experimental dengan desain penelitian One-Group-Pretest-Posttest Design. Subjek penelitian ini adalah siswa kelas IV SD IT Humairoh 2 Pekanbaru sebagai kelas eksperimen. Penelitian ini menggunakan aplikasi Quizizz sebagai alat evaluasi atau penilaian setiap akhir pembelajaran. Hasil penelitian menunjukkan pada data pretest memperoleh rata-rata 50.00 dan hasil posttest adalah 82.80. Perhitungan uji hipotesis memperoleh hasil sig (2-tailed) 0.000 < 0.05 yang menunjukkan bahwa penggunaan aplikasi Quizizz dapat meningkatkan hasil belajar IPS siswa kelas IV sekolah dasar. Berdasarkan hasil uji N-Gain didapatkan peningkatan hasil belajar kelas eksperimen sebesar 64.0% yang termasuk pada kategori efektif. Kemudian untuk melihat seberapa besar pengaruh yang diberikan dihitung dengan uji Koefisien Determinasi (R-Square) diperoleh hasil sebesar 0.524%. Sehingga disimpulkan bahwa penggunaan aplikasi Quizizz efektif dalam meningkatkan hasil belajar siswa kelas IV Sekolah Dasar.
High resolution upper crustal velocity and seismogenic structure of the Huoshan “seismic window” in the Dabie orogenic belt
Authors: Li Lingli , Yao Huajian , Zhang Bing , Li Junhui , Shu Peng , Yang Yuanyuan , Wang Xiaoli , Zhou Dongrui , Zhao Peng , Luo Jiaji 
Published: February 2023

Huoshan “seismic window” is located in the northern margin of the Dabie Orogen belt, the contact zone between North China and the Yangtze plate, where the seismic activity is mainly concentrated in this area. Small earthquake swarms in this region often appear before significant moderate-strong earthquakes in East China. To reveal the fine structures of several faults and discuss their correlation with the seismic activity, a seismic array composed of 136 sets of short period seismometers was deployed in the Huoshan region and its surrounding areas. Ambient noise data were recorded for 1 month, and a 3-D velocity structure model of the upper crust was constructed. The results show that with the Meishan-Longhekou and Qingshan-Xiaotian faults as the boundary, the Dabie Mountain, Hefei Basin, North Dabie and North Huaiyang show exhibit obvious high and low velocity variation characteristics. The shallow crust along the NW-trending, normal Qingshan-Xiaotian fault, presents a high velocity zonal distribution, which is related to the large number of magmatic and metamorphic rocks exposed under the strong metamorphic power in this region. The NE-trending Tudiling-Luoerling fault comprised three groups of parallel and nearly vertical en echelon secondary faults in the upper crust, which control most of the seismic activities. A relatively low velocity anomaly is observed in the seismic concentrated occurrence layer near the intersection of the fault. It suggests that this area inherits the property of the low velocity detachment zone of the middle crust in the wing of the Dabie Mountain dome structure, and a relatively broken weak structural zone form near the intersection of the fault, which leads to the release of small strain accumulation, thus enriching small earthquake activities. The focal depth of earthquakes above ML3 mainly distribute along the Tudiling-Luoerling fault plane, which is indicated this fault is the main seismogenic fault of greater seismicity in Huoshan “seismic window”. This study provides an important model basis for reliable earthquake location, focal mechanism and the determination of possible earthquake risk sites, and provides a reference for the further study of small earthquake activity mechanism of other “seismic windows” in China.
Double systemic cytokine release syndrome following sequential infusion of anti-CD22 and anti-CD19 chimeric antigen receptor T cells after autologous hematopoietic stem cell transplantation for a central diffuse large B-cell lymphoma patient: A case report and literature review
Authors: Zheng Jing , Xiao Yao , Wu Xue Q. , Xiao Qiong Z. , Feng Chun , Gao Kai B. 
Published: January 2023

BackgroundChimeric Antigen Receptor T cell(CAR T-cell) therapy has been a great success in relapsed/refractory acute B lymphoblastic leukemia and B-cell lymphoma. At the same time, there are also related adverse reactions, especially cytokine release syndrome(CRS) and immune effector cell associated neurotoxicity syndrome(ICANS). However, Double CRS caused by CRA T cells are very rare.Case reportHere, we report a 33-year-male with secondary central diffuse large B-cell lymphoma(CNSL) who develpoed double CRS following sequential infusion of Anti-CD22 and Anti-CD19 CAR T cells after autologous hematopoietic stem cell transplantation(ASCT). On d+5, the patient developed high fever, along with chilly sensation, shivering, headache, blood oxygen desaturation, shock, weakness, severe thirst, and heart rate decline. IL-6 and ferritin increased significantly. The patient was diagnosed with the first CRS (grade 3). On d+36, the patient again had a persistent fever(T&gt;39C) and limbs rash. IL-6 and ferritin again increased significantly on d+38. After exclusion of infection, a diagnosis of double CRS was made. The patient’s symptoms were completely relieved after receiving tocilizumab, glucocorticoids, and other supportive treatments on d+45.On d+90, contrast-enhanced MR angiogram shows that the lesion basically disappeared, indicating the patient had achieved CR. At the end of the follow-up at d+150, the patient was functioning normally without any sequelae.ConclusionThis is the first reported case worldwide where the patient with secondary CNSL suffered double CRS after CAR T-cell infusion. Our findings showed that it is important to increase awareness of early detection and diagnosis of double CRS and adopt appropriate treatment strategies.
Decreased granzyme-B expression in CD11c+CD8+ T cells associated with disease progression in patients with HBV-related hepatocellular carcinoma
Authors: Gao Lin , Hong Zhixian , Lei Guanglin , Guo An-Liang , Wang Fu-Sheng , Jiao Yan-Mei , Fu Junliang 
Published: January 2023

IntroductionCD11c+CD8+ T cells are an unconventional CD8+ T cell subset that exerts antiviral activity in infectious diseases. However, its characteristics in hepatocellular carcinoma (HCC) have not been elucidated.MethodsTwenty-six patients with hepatitis B virus (HBV)-related HCC and 25 healthy controls (HC) were enrolled. The frequency and phenotype of CD11c+CD8+ T cells in peripheral blood and tumors in situ were detected by flow cytometry and immunohistochemistry.ResultsBoth the HCC group and HC group had similar frequency and phenotype characteristics of CD11c+CD8+ T cells in the periphery. CD11c+CD8+ T cells were mainly composed of effector T cells, most of which were CD45RA+CCR7-. Compared with CD11c-CD8+ T cells, CD11c+CD8+ T cells had a higher proportion of CD38 and HLA-DR double positive, and expressed high levels of granzyme-B (GB) and degranulation marker CD107a, and produced high levels of interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ). However, the ability of degranulation and TNF-α production of CD11c+CD8+ T cells in patients with HCC were significantly lower than that in healthy controls. The GB expression level of peripheral CD11c+CD8+ T cells in patients with advanced stage of HCC was significantly lower than that in patients with early stage of HCC, and the GB expression level of liver-infiltrating CD11c+CD8+ T cells in tumor tissues was lower than that in non-tumor tissues. More importantly, the GB expression level of peripheral CD11c+CD8+ T cells was negatively correlated with tumor volume. ConclusionsThese findings indicate that CD11c+CD8+ T cells may have potential anti-tumor activity and that GB+CD11c+CD8+ T cells are associated with disease progression in patients with HBV-related HCC.
Predictors and long-term outcome of intracranial hemorrhage after thrombolytic therapy for acute ischemic stroke—A prospective single-center study
Authors: Fekete Klára Edit , Héja Máté , Márton Sándor , Tóth Judit , Harman Aletta , Horváth László , Fekete István 
Published: February 2023

IntroductionAcute ischemic stroke (AIS) is a potentially devastating disease with high disability and mortality. Recombinant tissue plasminogen activator (rt-PA) is an effective treatment with a 2–8% possible risk for symptomatic intracranial hemorrhage (sICH). Our aim was to investigate the risk factors and long-term clinical outcomes of ICH in patients after rt-PA treatment.MethodsConsecutive patients with AIS, thrombolysed at the Department of Neurology, University of Debrecen, between 1 January 2004 and 31 August 2016 were enrolled prospectively. Risk factors, stroke severity based on the National Institute of Health Stroke Scale (NIHSS), functional outcome using the modified Rankin scale, and mortality at 1 year were compared in patients with and without ICH following rt-PA treatment. We evaluated clinical characteristics and prognosis by hemorrhage type based on the Heidelberg Bleeding Classification. Descriptive statistics, the chi-square test, the Mann–Whitney U-test, ANOVA, the Kruskal–Wallis test, a survival analysis, and logistic regression were performed as appropriate.ResultsOut of 1,252 patients with thrombolysis, ICH developed in 138 patients, with 37 (2.95%) being symptomatic. Mean ages in the ICH and non-ICH groups differed significantly (p = 0.041). On admission, the 24-h NIHSS after thrombolysis was higher in patients with ICH (p &lt; 0.0001). Large vessel occlusion was more prevalent in patients with ICH (p = 0.0095). The ICH risk was lower after intravenous thrombolysis than intra-arterial or combined thrombolysis (p &lt; 0.0001). Both at 3 months and 1 year, the outcome was worse in patients with ICH compared to patients without ICH group (p &lt; 0.0001). Mortality and poor outcome were more prevalent in all hemorrhage types with a tendency for massive bleeding associated with unfavorable prognosis. At 3 months with the logistic regression model, the worse outcome was detected in patients with ICH after thrombolysis, at 1 year in patients with ICH after thrombolysis and smoking.DiscussionOlder age, higher NIHSS, large vessel occlusion, and intra-arterial thrombolysis may correlate with ICH. The unfavorable outcome is more common in patients with ICH. Precise scoring of post-thrombolysis bleeding might be a useful tool in the evaluation of the patient's prognosis. Our findings may help to identify predictors and estimate the prognosis of ICH in patients with AIS treated with rt-PA.
Survival effect of pre-RT PET-CT on cervical cancer: Image-guided intensity-modulated radiation therapy era
Authors: Su Chih-Hsiung , Chen Wan-Ming , Chen Mingchih , Shia Ben-Chang , Wu Szu-Yuan 
Published: January 2023

Condensed abstractNo large-scale, well-designed randomized study with a long-term follow-up has evaluated the survival effect of pretreatment 18-fluorodeoxyglucose positron emission tomography–computed tomography (18FDG-PET–CT) on patients with stage IB–IVA cervical cancer receiving image-guided intensity-modulated radiation therapy (IG-IMRT). This is the first head-to-head propensity score–matched, nationwide population-based cohort study evaluating this survival effect. The results revealed that pretreatment 18FDG-PET–CT might be associated with longer survival in patients with stage IB–IVA cervical cancer receiving radiotherapy or concurrent chemoradiotherapy, especially in the IG-IMRT era.PurposeNo large-scale, well-designed randomized study with a long-term follow-up has evaluated the survival effect of pretreatment 18-fluorodeoxyglucose positron emission tomography–computed tomography (18FDG-PET–CT) on patients with stage IB–IVA cervical cancer receiving image-guided intensity-modulated radiation therapy (IG-IMRT). Therefore, in this propensity score–matched, population-based cohort study, we investigated these survival effects.Patients and methodsWe included 4167 patients with stage IB–IVA cervical cancer receiving radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) through the IG-IMRT technique. The patients were categorized into two 1:2 propensity score–matched groups depending on whether they underwent pretreatment 18FDG-PET–CT, and their outcomes were compared.ResultsWe included 2778 and 1389 patients with cervical cancer in the nonpretreatment and pretreatment PET–CT groups, respectively. Univariable and multivariable analyses revealed an association between pretreatment PET–CT and improved survival in the patients (in the adjusted model, the adjusted hazard ratio [aHR] was 0.88; 95% confidence interval [CI], 0.80–0.97: P = 0.010). Regardless of the cancer stage (early or advanced), pretreatment PET–CT was significantly superior to nonpretreatment PET–CT in terms of all-cause death (aHR, 0.78; 95% CI, 0.60–0.92; P = 0.013 and aHR, 0.90; 95% CI, 0.81–0.99; P = 0.039 for the early [IB–IIA] and advanced stages [IIB–IVA], respectively).ConclusionsPretreatment 18FDG-PET–CT might be associated with longer survival in patients with stage IB–IVA cervical cancer receiving RT or CCRT, especially in the era of IG-IMRT.
Construction of a high-resolution genetic map and identification of single nucleotide polymorphism markers relevant to flower stalk height in onion
Authors: Li Yanwei , Huo Yumeng , Yang Yanyan , Wang Zhenbao , Sun Yaling , Liu Bingjiang , Wu Xiong 
Published: January 2023

IntroductionOnion (Allium cepa L., 2n=16) is an economically and nutritionally important vegetable crop worldwide. Construction of a high-resolution genetic map and map-based gene mining in onion have lagged behind other vegetable crops such as tomato and pepper.MethodsIn this study, we constructed a high-resolution genetic map of onion using 321 F2 individuals from a cross between two double haploid lines DH-1×DH-17 and employing specific length amplified fragment (SLAF)-seq technology. The genetic map containing 10,584 polymorphic SLAFs with 21,250 single nucleotide polymorphism (SNP) markers and 8 linkage groups was developed for onion, which spanned 928.32 cM, with an average distance of 0.09 cM between adjacent markers.ResultsUsing this map, we carried out QTL mapping of Ms locus related to the male-fertile trait and reproduced previous mapping results, which proved that this map was of good quality. Then, four QTLs (located on LG2, LG5, and LG8) were detected for flower stalk height, explaining 26.60% of the phenotypic variance. Among them, we proposed that 20 SLAF markers (in three QTLs) of flower stalk height trait were effective favorable allelic variant markers associated with heterosis.DiscussionOverall, the genetic map was structured using SLAF-seq based on DH lines, and it is the highest-quality and highest-resolution linkage map of onion to date. It lays a foundation for the fine mapping and candidate gene identification of flower stalk height, and provides new insights into the developmental genetic mechanisms in onion breeding.
Poor sleep quality and erectile dysfunction in students from a Peruvian University: A cross-sectional study
Authors: Gutierrez-Velarde Pierina , Valladares-Garrido Mario J. , Peralta C. Ichiro , Vera-Ponce Victor J. , Grandez-Urbina J. Antonio 
Published: February 2023

ObjectiveWe aimed to evaluate the association between sleep quality and erectile dysfunction in young university students.MethodsA cross-sectional survey was conducted in men aged 18–30 years from Universidad Ricardo Palma, Lima, Peru. The survey comprised the International Index of Erectile Function, Pittsburgh Sleep Quality Index, Berlin questionnaire, and questions related to sociodemographic data. Prevalence ratios were estimated with generalized linear models.ResultsOf 381 participants, the median age was 23 years. Half of the students (50.9%) had poor sleep quality, of which 72.7% had mild erectile dysfunction and 20.6% mild to moderate dysfunction. Prevalence of erectile dysfunction was significantly higher in students with poor sleep quality than in students with good sleep quality (aPR = 6.48; 95% CI: 4.58–9.17) after adjusting for age, academic year, nutritional status, and sleep apnea. In a subsequent exploratory analysis, sleep apnea was associated with a higher prevalence of erectile dysfunction (aPR = 1.19; 95% CI: 1.01–1.39), while overweight (aPR = 0.85; 95% CI: 0.76–0.95) and obesity (aPR = 0.65; 95% CI: 0.52–0.82) were associated with a lower prevalence of this condition.ConclusionPoor sleep quality was independently associated with erectile dysfunction in young university students. This finding suggests that male students are at risk for sexual problems due to possible academic demands and relationship issues.
Optimising personal continuity: a survey of GPs’ and older patients’ views
Authors: Groot Lex , te Winkel Marije , Schers Henk , Burgers Jako , Smalbrugge Martin , Uijen Annemarie , van der Horst Henriëtte , Maarsingh Otto 
Published: January 2023

BackgroundPersonal continuity — having a GP who knows their patients and keeps track of them — is an important dimension of continuity of care and is associated with lower mortality rates, higher quality of life, and reduced healthcare costs. In recent decades it has become more challenging for GPs to provide personal continuity owing to changes in society and health care.AimTo investigate GPs’ and older patients’ views on personal continuity and how personal continuity can be improved.Design & settingCross sectional survey study in The Netherlands.MethodA digital and postal survey was sent to 499 GPs and 1599 patients aged 65 years or older. Results were analysed using descriptive statistics for quantitative data and thematic analysis for open questions.ResultsIn total, 249 GPs and 582 patients completed the surveys. A large majority of GPs (92–99%) and patients (91–98%) felt it was important for patients to see their own GP for life events or psychosocial issues. GPs and patients provided suggestions on how personal continuity can be improved. The thematic analysis of these suggestions identified nine themes: 1) personal connection, 2) GP accessibility and availability, 3) communication about (dis)continuity, 4) GP responsibility, 5) triage, 6) time for the patient, 7) actions by third parties, 8) team continuity, and 9) GP vocational training.ConclusionBoth GPs and older patients still place high value on personal continuity in the context of a changing society. GPs and patients provided a wide range of suggestions for improving personal continuity. The authors will use these suggestions to develop interventions for optimising personal continuity in general practice.
ANALISIS PENERAPAN STRATEGI PEMASARAN PERALATAN PELABUHAN DENGAN MENGGUNAKAN PENDEKATAN ANALISIS SWOT PADA PT TOWIN INNOVEN
Authors: Prisdina Nanda Bella , Fatururrahman Mujtabah 
Published: January 2023

<p align="justify">This research is motivated by the increasing number of companies engaged in contractors. The number of competitors who market the same product also has an impact on sales at PT Towin Innoven. Marketing strategy is an important part of implementing a business. The formulation of the problem in this study is how the marketing strategy of port equipment with the SWOT technique at PT. Towin Innoven? which aims to find out how the results of the SWOT analysis in the marketing strategy at PT Towin Innoven. In this study, the type of qualitative research is descriptive. Because in this study also to determine the external and internal conditions of the company. In this case the researcher uses data collection techniques such as: observation, interviews and documentation and uses data triangulation techniques to compare the results of the data in the study. The technical tool used is swot analysis. The results shown by the SWOT analysis diagram show that the company is in quadrant I, namely the SO (Strength Opportunity) strategy which supports an aggressive strategy (growth oriented strategy). This is a very profitable situation for the company. Where, the company has the power so that it can take advantage of existing opportunities.</p><p> </p><p><strong>Keywords: </strong>Marketing Strategy, SWOT Analysis, Port Equipment.</p>