bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐power and low‐cost sodium‐ion batteries with a wide operation temperature from −70 °C to 130 °C
Authors: Li Zhi , Zhang Yu , Wang Yonggang 
Published: February 2023

AbstractLow‐cost sodium‐ion batteries (SIBs) are promising candidates for grid‐scale energy‐storage systems, and the wide‐temperature operations of SIBs are highly demanded to accommodate extreme weather. Herein, a low‐cost SIB is fabricated with a Na4Fe3(PO4)2P2O7 (NFPP) cathode, a natural graphite (NG) anode, and an ether‐based electrolyte. The prepared NG//NFPP batteries deliver a long lifespan of 1000 cycles, high‐power density of 5938 W/kg, and remarkable rate performance of 10 A/g with a high capacity retention of 60%. Benefiting from the solvent co‐intercalation process of the NG anode and the high Na+ diffusion rate of the NFPP cathode, the NG//NFPP battery displays outstanding performance at −40 °C and even can work at an ultralow temperature of −70 °C. Furthermore, the high boiling point of the electrolytes and high thermal stability of the electrode materials also enable the high‐temperature operation of the full battery up to 130 °C. This work will guide the design of the wide‐temperature SIBs.
Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
Authors: Drew Damien R. , Wilson Danny W. , Weiss Gretchen E. , Yeoh Lee M. , G. Henshall Isabelle , Crabb Brendan S. , Dutta Sheetij , Gilson Paul R. , Beeson James G. 
Published: February 2023

AbstractPlasmodium falciparum and P. vivax are the major causes of human malaria, and P. knowlesi is an important additional cause in SE Asia. Binding of apical membrane antigen 1 (AMA1) to rhoptry neck protein 2 (RON2) was thought to be essential for merozoite invasion of erythrocytes by Plasmodium spp. Our findings reveal that P. falciparum and P. vivax have diverged and show species-specific binding of AMA1 to RON2, determined by a β-hairpin loop in RON2 and specific residues in AMA1 Loop1E. In contrast, cross-species binding of AMA1 to RON2 is retained between P. vivax and P. knowlesi. Mutation of specific amino acids in AMA1 Loop1E in P. falciparum or P. vivax ablated RON2 binding without impacting erythrocyte invasion. This indicates that the AMA1–RON2-loop interaction is not essential for invasion and additional AMA1 interactions are involved. Mutations in AMA1 that disrupt RON2 binding also enable escape of invasion inhibitory antibodies. Therefore, vaccines and therapeutics will need to be broader than targeting only the AMA1–RON2 interaction. Antibodies targeting AMA1 domain 3 had greater invasion-inhibitory activity when RON2-loop binding was ablated, suggesting this domain is a promising additional target for vaccine development. Targeting multiple AMA1 interactions involved in invasion may enable vaccines that generate more potent inhibitory antibodies and address the capacity for immune evasion. Findings on specific residues for invasion function and species divergence and conservation can inform novel vaccines and therapeutics against malaria caused by three species, including the potential for cross-species vaccines.
Thunder and lightning—a report on firework-associated acoustic trauma at New Year 2021/2022
Authors: Flockerzi Veronika , Schick Bernhard ,   German Acoustic Fireworks-associated Traumata Study (GAFATS) Group, Ilgner Justus , Hesse Gerhard , Jecker Peter , Eichwald Herbert , Dommerich Steffen , Gerstner Andreas O. H. , Hoppe Stephanie , Ebmeyer Jörg , Thomas Jan Peter , Papst Friedemann , Hornung Joachim , Lang Stephan , Knopf Andreas , Dost Philipp , Arens Christoph , Wrobel Christian , Langer Jörg , Münscher Adrian , Lenarz Thomas , Cem Bulut Olcay , Hein Matti , Inhestern Johanna , Flockerzi Veronika , Schick Bernhard , Bozzato Alessandro , Federspil Philippe , Ambrosch Petra , Schmidt Sandra , Ebeling O. , Papatsoutsos Efastathios , Scherl Claudia , Schmidt Sandra , Stuck Boris A. , Hofauer Benedikt , Al Kadah Basel , Bumm Klaus , Jäckel Martin C. , Hilger Gregor , Muschal Birgit , Becker Sven , Evers Theo , Bozzato Alessandro 
Published: February 2023

Abstract
Background
This cross-sectional study aimed to assess the frequency and type of firework-associated acoustic trauma occurring in Germany on New Year’s Eve 2021, despite the ban on firework sales due to the COVID-19 pandemic.

Materials and methods
The survey period lasted 7 days, from 28 December 2021 to 03 January 2022. A questionnaire inquired date, type and treatment of trauma, sex, and age of the patient, and whether the trauma occurred when lighting or watching fireworks. Hearing impairment was classified according to the World Health Organization (WHO grades 0 to 4), and concomitant tinnitus, vertigo, or other injuries were recorded. The questionnaire was sent to the otorhinolaryngology departments of 171 hospitals in Germany.

Results
Of 37 otorhinolaryngology departments, 16 reported no and 21 reported 50 patients with firework-associated acoustic trauma. Mean age was 29 ± 16 years and 41 of 50 patients were males. Of these 50 patients, 22 presented without and 28 with hearing loss, 32 reported tinnitus and 3 vertigo; 20 patients were injured when lighting fireworks and 30 when watching. Hearing impairment was classified as 14 × WHO grade 0, 5 × WHO grade 1, 4 × WHO grade 2, 2 × WHO grade 3, and 3 × WHO grade 4. Inpatient treatment was received by 8 patients and 11 suffered from concomitant burn injuries.

Conclusion
Despite the sales ban, some firework-associated acoustic traumas occurred at New Year 2021/2022 in Germany. Some instances led to hospitalization, but an even higher number of unreported cases can be assumed. This study can serve as a baseline for further annual surveys to raise the awareness of the danger of seemingly harmless fireworks for the individual.
Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study
Authors: Wei Yuxia , Richardson Tom G. , Zhan Yiqiang , Carlsson Sofia 
Published: February 2023

Abstract
Aims/hypothesis
We investigated whether the impacts of childhood adiposity on adult-onset diabetes differ across proposed diabetes subtypes using a Mendelian randomisation (MR) design.

Methods
We performed MR analysis using data from European genome-wide association studies of childhood adiposity, latent autoimmune diabetes in adults (LADA, proxy for severe autoimmune diabetes), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD).

Results
Higher levels of childhood adiposity had positive genetically predicted effects on LADA (OR 1.62, 95% CI 1.05, 2.52), SIDD (OR 2.11, 95% CI 1.18, 3.80), SIRD (OR 2.76, 95% CI 1.60, 4.75) and MOD (OR 7.30, 95% CI 4.17, 12.78), but not MARD (OR 1.06, 95% CI 0.70, 1.60).

Conclusions/interpretation
Childhood adiposity is a risk factor not only for adult-onset diabetes primarily characterised by obesity or insulin resistance, but also for subtypes primarily characterised by insulin deficiency or autoimmunity. These findings emphasise the importance of preventing childhood obesity.

Graphical abstract
Stationary probability measures on projective spaces 1: block-Lyapunov dominated systems
Authors: Aoun Richard , Sert Cagri 
Published: February 2023

AbstractGiven a finite-dimensional real vector space V, a probability measure $$\mu $$
μ
on $${\text {PGL}}(V)$$

PGL
(
V
)

and a $$\mu $$
μ
-invariant subspace W, under a block-Lyapunov contraction assumption, we prove existence and uniqueness of lifts to $$P(V){\setminus } P(W)$$

P
(
V
)
\
P
(
W
)

of stationary probability measures on the quotient P(V/W). In the other direction, i.e. block-Lyapunov expansion, we prove that stationary measures on P(V/W) have lifts if any only if the group generated by the support of $$\mu $$
μ
stabilizes a subspace $$W'$$

W
′

not contained in W and exhibiting a faster growth than on $$W \cap W'$$

W
∩

W
′

. These refine the description of stationary probability measures on projective spaces as given by Furstenberg, Kifer and Hennion, and under the same assumptions, extend corresponding results by Aoun, Benoist, Bruère, Guivarc’h, and others.
Use of Temporary Abdominal Closure in Non‐Trauma Surgery: A Cohort Study
Authors: Peng Calvin C. , Tay Jia , Tham Nicole , Tully Emma K. , Shakerian Rose , Furlong Tim , Thomson Benjamin N. J. , Hayes Ian P. 
Published: February 2023

AbstractBackgroundDamage control surgery in trauma is widely used but the evidence for the use of laparostomy in non‐trauma abdominal emergencies is limited. This study aimed to characterise outcomes in emergency abdominal surgery by comparing laparostomy to one‐stage laparotomy for patients of similar illness severity.MethodsA retrospective study of adult patients requiring emergency abdominal surgery and post‐operative intensive care stay was performed between 2016 and 2020 at a major Australian metropolitan hospital. Case selection was from a prospectively maintained database, and case notes were reviewed. Patients having delayed abdominal closure were compared with those having one‐stage abdominal closure. The primary outcome was odds of in‐hospital mortality. The secondary outcomes included intensive care unit length of stay (LOS), overall hospital LOS, definitive stoma rate and discharge destination. Multivariable logistic regression analysis was performed to adjust for potentially confounding variables.ResultsTwo hundred and eighteen patients met inclusion criteria (80 laparostomy and 138 non‐laparostomy). The most common indications for laparostomy were bowel ischaemia (41.3%), sepsis (26.3%) and physiological instability (22.5%). There was no evidence of difference in odds of in‐hospital mortality between groups (adjusted OR = 1.67, CI: 0.85–3.28; p = 0.138). Patients requiring laparostomy had a slightly longer median ICU LOS (4 vs. 3 days; p < 0.001), similar median hospital LOS (19 vs. 14 days, p = 0.245) and similar discharge destination. There was no difference in stoma rate (35.0% vs. 35.5%).ConclusionCompared with standard one‐stage laparotomy, laparostomy resulted in similar odds of in‐hospital mortality in emergency abdominal surgery patients requiring intensive care.
Starches in the encapsulation of plant active ingredients: state of the art and research trends
Authors: Montoya-Yepes Diego F. , Jiménez-Rodríguez Angel A. , Aldana-Porras Alvaro E. , Velásquez-Holguin Luisa F. , Méndez-Arteaga Jonh J. , Murillo-Arango Walter 
Published: February 2023

AbstractAs a natural polymer, starches and their derivatives have received widespread attention in the cosmetic and pharmaceutical industries, particularly for their use as a coating material. In this sense, as an encapsulating agent, starches stand out, considering the number of compounds that they can trap. Additionally, they provide a nutritional contribution and may improve acceptance by patients. As such, this type of material may serve as an alternative to overcome gaps such as loss of activity of the active principles, low assimilation, or deterioration under environmental and physiological conditions. In this paper, we aim to present the state of the art and research trends on the use of starch as a wall material for the encapsulation of active principles of plant origin. It was found that the most-encapsulated active principles are essential oils and polyphenols; native or modified starches are typically used, either as the sole wall material or in combination with other polymers; and the most widely used methodology is spray drying. The reviewed studies indicate the potential of starches for their use in active ingredient encapsulation processes, improving their viability and expanding their range of applications in different industries, as well as showing a clearly increasing publication trend over the last 10 years.
Graphical abstract
Ovarian cancer prevention by opportunistic salpingectomy is a new de facto standard in Germany
Authors: Runnebaum I. B. , Kather A. , Vorwergk J. , Cruz J. J. , Mothes A. R. , Beteta C. R. , Boer J. , Keller M. , Pölcher M. , Mustea A. , Sehouli J. 
Published: February 2023

Abstract
Purpose

The most prevalent and aggressive subtype of epithelial ovarian carcinoma (EOC), high-grade serous carcinoma (HGSC), originates in many cases from the fallopian tubes. Because of poor prognosis and lack of effective screening for early detection, opportunistic salpingectomy (OS) for prevention of EOC is being implemented into clinical routine in several countries worldwide. Taking the opportunity of a gynecological surgery in women at average cancer risk, extramural fallopian tubes are completely resected preserving the ovaries with their infundibulopelvic blood supply. Until recently, only 13 of the 130 national partner societies of the International Federation of Obstetrics and Gynecology (FIGO) have published a statement on OS. This study aimed to analyze the acceptance of OS in Germany.

Methods

(1) Survey of German gynecologists in 2015 and 2022 by the Department of Gynecology of the Jena University Hospital in co-operation with the Department of Gynecology at Charité-University Medicine Berlin with support of NOGGO e. V. and AGO e. V. (2) Salpingectomy numbers in Germany for years 2005–2020 as retrieved from the Federal Statistical Office of Germany (Destatis).

Results

(1) Survey: Number of participants was 203 in 2015 and 166 in 2022, respectively. Nearly all respondents (2015: 92%, 2022: 98%) have already performed bilateral salpingectomy without oophorectomy in combination with benign hysterectomy with the intention to reduce the risk for malignant (2015: 96%, 2022: 97%) and benign (2015: 47%, 2022: 38%) disorders. Compared to 2015 (56.6%), considerably more survey participants performed OS in > 50% or in all cases in 2022 (89.0%). Recommendation of OS for all women with completed family planning at benign pelvic surgery was approved by 68% in 2015 and 74% in 2022. (2) Case number analysis: In 2020, four times more cases of salpingectomy were reported by German public hospitals compared to 2005 (n = 50,398 vs. n = 12,286). Of all inpatient hysterectomies in German hospitals in 2020, 45% were combined with salpingectomy, and more than 65% in women at the age of 35 to 49 years.

Conclusion
Mounting scientific plausibility regarding involvement of fallopian tubes in the pathogenesis of EOC led to change of clinical acceptance of OS in many countries including in Germany. Case number data and widespread expert judgment demonstrate that OS has become a routine procedure in Germany and a de facto standard for primary prevention of EOC.
Comparison of two intraductal brush cytology devices for suspected malignant biliary strictures: randomized controlled trial
Authors: Gorris Myrte , van Huijgevoort Nadine C. M. , Fockens Paul , Meijer Sybren L. , Verheij Joanne , Voermans Rogier P. , van Wanrooij Roy L. J. , Lekkerkerker Selma J. , van Hooft Jeanin E. 
Published: February 2023

Abstract
Background
Endoscopic retrograde cholangiopancreatography (ERCP) with biliary brush cytology is commonly used to diagnose malignant pancreatobiliary strictures. This trial compared the sensitivity of two intraductal brush cytology devices.

Methods
A randomized controlled trial in which consecutive patients with suspected malignant, extrahepatic biliary strictures were randomized (1:1) to a dense or conventional brush cytology device. Primary endpoint was sensitivity. Interim analysis was conducted after 50% of the patients completed follow-up. Results were interpreted by a data safety monitoring board.

Results
Between June 2016 and June 2021, 64 patients were randomized to the dense (27 patients, 42%) or conventional brush (37 patients, 58%). Malignancy was diagnosed in 60 patients (94%) and benign disease in 4 patients (6%). Diagnoses were confirmed by histopathology in 34 patients (53%), cytopathology in 24 patients (38%), and clinical or radiological follow up in 6 patients (9%). Sensitivity of the dense brush was 50%, compared to 44% for the conventional brush (p = 0·785).

Discussion
The results of this randomized controlled trial showed that the sensitivity of a dense brush is not superior to a conventional brush for diagnosing malignant extrahepatic pancreatobiliary strictures. This trial was prematurely ended for reasons of futility.

Trial registration
Netherlands Trial Register number; NTR5458.
Efficiency and selectivity of cost-effective Zn-MOF for dye removal, kinetic and thermodynamic approach
Authors: Elsherbiny Abeer S. , Rady Ahmed , Abdelhameed Reda M. , Gemeay Ali H. 
Published: February 2023

AbstractGreen synthesis of metal–organic frameworks (MOFs) has attracted a lot of attention as a crucial step for practical industrial applications. In this work, green synthesis of zinc(II) metal–organic framework (Zn-MOF) has been carried out at room temperature. The Zn metal (node) was extracted from spent domestic batteries, and the linker was benzene di-carboxylic acid (BDC). The characterization of the as-prepared Zn-MOF was accomplished by PXRD, FT-IR spectroscopy, SEM, TEM, TGA, and nitrogen adsorption at 77 K. All the characterization techniques strongly supported that as-synthesized Zn-MOF using metallic solid waste Zn is similar to that was reported in the literature. The as-prepared Zn-MOF was stable in water for 24 h without any changes in its functional groups and framework. The prepared Zn-MOF was tested for the adsorption of three dyes, two anionic dyes, aniline blue (AB), and orange II (O(II)) as well as methylene blue (MB), an example of cationic dye from aqueous solution. AB has the highest equilibrium adsorbed amount, qe, of value 55.34 mg g−1 at pH = 7 and 25 °C within 40 min. Investigation of the adsorption kinetics indicated that these adsorption processes could be described as a pseudo-second-order kinetic model. Furthermore, the adsorption process of the three dyes was described well by the Freundlich isotherm model. According to the thermodynamic parameters, the adsorption of AB on the prepared Zn-MOF was an endothermic and spontaneous process. In contrast, it was non-spontaneous and exothermic for the uptake of O(II) and MB. This study complements the business case development model of “solid waste to value-added MOFs.”
Utility of mono-exponential, bi-exponential, and stretched exponential signal models of intravoxel incoherent motion (IVIM) to predict prognosis and survival risk in laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) patients after chemoradiotherapy
Authors: Zhang Ya , Luo Dehong , Guo Wei , Liu Zhou , Zhao Xinming 
Published: February 2023

Abstract
Purpose

To investigate the predictive power of mono-exponential, bi-exponential, and stretched exponential signal models of intravoxel incoherent motion (IVIM) in prognosis and survival risk of laryngeal and hypopharyngeal squamous cell carcinoma (LHSCC) patients after chemoradiotherapy.

Materials and methods

Forty-five patients with laryngeal or hypopharyngeal squamous cell carcinoma were retrospectively enrolled. All patients had undergone pretreatment IVIM examination, subsequently, mean apparent diffusion coefficient (ADCmean), maximum ADC (ADCmax), minimum ADC (ADCmin) and ADCrange (ADCmax − ADCmean) by mono-exponential model, true diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f) by bi-exponential model, distributed diffusion coefficient (DDC), and diffusion heterogeneity index (α) by stretched exponential model were measured. Survival data were collected for 5 years.

Results

Thirty-one cases were in the treatment failure group and fourteen cases were in the local control group. Significantly lower ADCmean, ADCmax, ADCmin, D, f, and higher D* values were observed in the treatment failure group than in the local control group (p < 0.05). D* had the greatest AUC of 0.802, with sensitivity and specificity of 77.4 and 85.7% when D* was 38.85 × 10–3 mm2/s. Kaplan–Meier survival analysis showed that the curves of N stage, ADCmean, ADCmax, ADCmin, D, D*, f, DDC, and α values were significant. Multivariate Cox regression analysis showed ADCmean and D* were independently correlated with progression-free survival (PFS) (hazard ratio [HR] = 0.125, p = 0.001; HR = 1.008, p = 0.002, respectively).

Conclusion
The pretreatment parameters of mono-exponential and bi-exponential models were significantly correlated with prognosis of LHSCC, ADCmean and D* values were independent factors for survival risk prediction.
Fatigue Analysis for Automotive Wheel Bearing Flanges
Authors: Jin Ji-Won , Kang Ki Weon , Lee Seungpyo 
Published: February 2023

AbstractThe automotive wheel bearing is an integral component of automobiles that transfers rotation and supports the weight of the vehicle. The life of automotive wheel bearings can be categorized into the raceway and flange lives. The raceway life is based on the spalling that occurs in the raceway and can be determined analytically using the basic rating life calculation method for the rolling bearing.
The flange life is based on failure involving the flange and can be numerically predicted through fatigue analysis. In particular, the fatigue analysis for predicting the flange life must consider rotation owing to the bearing characteristics, unlike the general fatigue analysis. In this study, we examined the fatigue analysis of the automotive wheel bearing flange while considering rotation. We performed sequential stress and fatigue analyses using commercial software. As the fatigue material properties are required for fatigue analysis, we obtained the properties by conducting a rotary bending fatigue test on the bearing materials. To verify the results of the analysis, we compared the analysis results with the test results. The validity of the proposed fatigue analysis was confirmed.
Effects of Pretreatment with a Ball Mill on Methane Yield of Horse Manure
Authors: Heller René , Roth Peter , Hülsemann Benedikt , Böttinger Stefan , Lemmer Andreas , Oechsner Hans 
Published: February 2023

AbstractLignocellulosic biomass is an abundant organic material, which can be utilised in biogas plants for sustainable production of biogas. Since these substrates usually have high lignin contents and consist of rather elongated particles, a special pretreatment is required for an economical and process-stable utilisation in the biogas plant. The mechanical pretreatment of horse manure was carried out with the prototype of a ball mill at different speeds. The aim of ball milling is to comminute the substrate and disintegrate the lignocellulosic bond. Mechanical pretreatment in the ball mill resulted in a significant increase in specific methane yield of more than 37% in anaerobic batch digestion (up to 243 LCH4 kgVS−1) of horse manure. The kinetics of the methane gas formation process was analysed by a modified Gompertz model fitting and showed a higher methane production potential and maximum daily methane production rate as well as a lower duration of the lag phase after pretreatment at 6 rpm. This was further confirmed by sieve analyses, which showed a significant reduction of particle size compared to the untreated variant. Thus, the use of the ball mill increases the specific methane yield and improves the fermentation of lignocellulosic substrates such as horse manure.
Graphical Abstract