bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pattern of gene expression (IGF family, muscle growth regulatory factors and osteogenesis related genes) involved in growth of skeletal muscle in pikeperch (Sander lucioperca) during ontogenesis
Authors: Lavajoo Fatemeh , Falahatkar Bahram , Perelló-Amorós Miquel , Moshayedi Fatemeh , Efatpanah Iraj , Gutiérrez Joaquim 
Published: September 2023

Abstract
The pikeperch (Sander lucioperca) is an economically important freshwater fish and a valuable food with high market acceptance. It is undergoing important changes in growth and regulatory metabolism during the ontogeny. Hence, the current study aims to investigate the mRNA expression of the growth hormone (gh)/insuline-like growth factor (igf) axis (ghr, igfI, igfbp, igfr), muscle regulatory factors (pax7, myf5, myod, myogenin, mrf, mymk, mstn) and osteogenesis related genes (colla1a, fib1a, on, op, ostn) from hatching through day 40th post hatching (DPH). The average total length (TL) of larvae measured at hatching was 3.6 ± 0.4 mm (67 degree-day) and at the end of experiment (40 DPH, 777 degree-day) was 27.1 ± 1.1 mm. The results showed three phases of gene expression in the egg, larval and juvenile stages of pikeperch ontogenesis. The expression pattern of fib1a and muscle gene myf5 showed the highest value at the egg stage. The growth hormone receptor gene (ghr), mymk and mstnb, raised to 1 DPH, whereas the expression of igf1rb and igf1bp5 was increased from 1 to 14 DPH. Increased expression of igfI, igfII, igf1bp4 and mrf4 was detected after 10 and 14 DPH. The myod1 expression raised at 8, 14 and 21 DPH. Differently myod2 showed only a large transient downregulation at 3 DPH and juvenile stage. The six genes igf1ra, pax7, myogenin, col1a1a, on, and ostc were highly expressed at 21 DPH and juvenile stage. Results from this study suggest that basal metabolism, growth of body cells, muscle and bone proliferation and development can be regulated by the dynamic changes in gene expression patterns in this species. The identified genes will help to understand the basic biological process of pikeperch larvae, and development, which is very important in pikeperch farming.
Dynastic Measures of Intergenerational Mobility
Authors: Bargain Olivier B. , Bue Maria C. Lo , Palmisano Flaviana 
Published: September 2023

Abstract

We suggest a simple and exible criterion to assess relative inter-generational mobility. It accommodates different types of outcomes, such as (continuous) earnings or(discrete and ordinal) education levels, and captures dynastic improvements of such outcomes at different points of the initial distribution. We provide dominance characterizations - for instance on the relative progress made by women vs. men - that areconsistent with social preferences upon desirable patterns of mobility. We suggest an application on Indonesia. Using the IFLS data, we match parents observed in 1993 totheir children in 2014, providing one of the rare intergenerational mobility analyses based on a long panel in the context of a developing country. Results indicate that mobility in terms of education and potential earnings was markedly at the advantage of women. The bulk of the population came out of illiteracy, possibly due to large scale education reforms, but the relative educational mobility was regressive, which considerably reduced the progressivity of mobility in terms of potential earnings.
JEL classification: J6, J62, O12.
A New Lightweight Authentication for Internet of Drones
Authors: Wang Shuhuan , Wang Yimin 
Published: September 2023

Abstract
As an important branch of the Internet of Things, Internet of Drones (loD) is changing the way of human life. However, loD suffer cyber attacks in practice. In 2021, Hussain et al. proposed an loD authentication scheme based on Elliptic Curve Cryptography (ECC) to solve this problem. Through analysis, their scheme is expensive to calculate and difficult to adapt to loD environment. As a result, a new lightweight authentication scheme based on secure one-way hash function and bitewise XOR operations was proposed. The experimental results show that the proposed scheme not only guarantees the safety, but also has lower computation cost. Thus, it is more suitable for loD.
Evaluation of the predictive capability of Response surface methodology (RSM) and Adaptive neuro-fuzzy inference system (ANFIS) in estimating biogas yield from poultry droppings, pig manure &amp; brewery spent grain using enzyme amylase
Authors: Onyiah Maxwell Ikemefuna , Gordian O. Mbah , Ude Callistus Nonso , Ude Michael Uzobuenyi 
Published: September 2023

Abstract

One of the biggest obstacles investigators face is predicting biogas yield, which is an enormous challenge because study in the field of simulation and optimization of biogas yield is still restricted, particularly with the adaptive neuro-fuzzy inference system (ANFIS). This study aims to develop and compare models that best predict the oxygen-independent decomposition of poultry droppings, pig manure and brewery spent grain for biogas production with the influence of enzyme amylase. The Response surface modelling (RSM) and a hybrid algorithm, Adaptive Neuro Fuzzy Inference System (ANFIS), was evaluated by considering temperature, residence duration, enzyme concentration, and pH as independent variables, while biogas generation served as the response or output factor. Relevant statistical metrics like AAD, MAE, RMSE and \({R}^{2}\) were applied to relate the adequacy of the two models. The performance of both RSM and ANFIS were compared based on the performance metrics. The calculated value of the coefficient of determination (\({R}^{2})\) for the biogas yield by implementing RSM using the enzyme amylase gave (\({R}_{PD}^{2}=0.9974, {R}_{PM}^{2}=0.9910 \& {R}_{BSG}^{2}=0.9975)\). This was compared with ANFIS results with an \({R}^{2}\) value of \(( {R}_{PD}^{2}=0.9986, {{R}_{PM}^{2}=0.9985 \& R}_{BSG}^{2}=0.9985).\) Analysis of the RSM and ANFIS results shows that the ANFIS prediction result is statistically marginal and presents the hybrid algorithm as a better prediction and optimization tool.
Comparison between continued inpatient treatment versus day patient treatment after short inpatient care in early onset anorexia nervosa (COTIDEA trial): a study protocol for a non- inferiority randomised controlled trial
Authors: Ayrolles Anaël , Bargiacchi A. , Clarke J. , Michel M. , Baillin F. , Trebossen V. , Kalifa H. Poncet , Guilemin-Crépon S. , Delorme R. , Godart N. , Stordeur C. 
Published: September 2023

Abstract
Background: In children with early-onset anorexia nervosa (first symptoms before 13 years old, EO-AN), experts recommend initial outpatient treatment but in-patient treatment (IP) is frequently indicated due to acute medical instability or for those who have not improved with outpatient treatment. This IP can target either a partial weight restauration or a total weight normalization (return to the previous BMI growth trajectory). There are no evidence in the literature on which is the better therapeutic option in EOAN. But as long length of stay induce social isolation, with elevated costs, we wonder if a stepped-care model of daypatient treatment (DP) after short IP stabilisation may be a treatment option as effective as full-time IP to target weight normalization. We designed a two-arm randomised controlled trial testing the non-inferiority of a stepped-care model of DP after short IP stabilisation versus full-time IP.
Methods: 88 children aged 8 to 13 years suffering from EOAN with initial severe undernutrition will be randomly allocated to either IP treatment as usual or a stepped care DP model both targeting weight normalization. Assessments will be conducted at inclusion, somatic stabilization, weight normalization, 6 months and 12 months post randomisation. The primary outcome will be BMI at 12 months post-randomisation. Secondaries outcomes will included clinical (tanner stage), biological (prealbumin, leptin, total ghrelin and IGF1) and radiological (bone mineralization and maturation) outcomes, eating symptomatology and psychiatric assessments, motivation to change, treatment acceptability and quality of life assessments, cost-utility and cost-effectiveness analyses.
Discussion: COTIDEA will provide rigorous evaluation of treatment alternative to full-time inpatient treatment to allow a reduction of social iatrogenic link to hospital length of stay and associated costs.
Trial registration: Trial is registered on ClinicalTrials.gov (NCT04479683).
Disease Recognition and Early Reporting of Suspected African Swine Fever In Baybay City, Leyte, Philippines: A KAP Study
Authors: Wheless Sheena Mae S. , Portugaliza Harvie P. 
Published: September 2023

Abstract

This study assessed the knowledge, attitudes, and practices (KAP) toward ASF recognition and early reporting in selected stakeholders in Baybay City, Leyte. A KAP survey was conducted among farmers, meat sellers, butchers, and LGU personnel (N= 270). Logistic regression analysis was performed to identify factors associated with each KAP score. Most stakeholders demonstrated poor knowledge of ASF recognition, reflecting a poor understanding of ASF concepts. Good knowledge of ASF, college education, and young age were associated with good knowledge of case reporting. Most stakeholders demonstrated good attitudes toward early reporting, correlating to a high education level. Most stakeholders are unlikely to consume or sell potentially infected pigs; however, stakeholders’ type and sex influenced these attitudes. Good knowledge and not good attitudes translated into good practices of ASF reporting. This KAP study reveals the need to improve knowledge and practices of ASF disease recognition and early case reporting, especially among farmers.
Antioxidant, Electrochemical, Photocatalysis and Sensor Studies of rGO Incorporated MgO Nanocomposite
Authors: M Mylarappa , S Chandruvasan , N Shravana Kumara K , R Sandhya 
Published: September 2023

Abstract
The main objective of this study is to develop the reduced graphene oxide (rGO) with magnesium oxide (MgO) nanoparticles. The obtained nanocomposite was characterized by using XRD, SEM and EDAX techniques. The developed rGO/MgO nanocomposite was utilized for antioxidant property. The Antioxidant activity of rGO, MgO and rGO/MgO nanocomposite were estimated using DPPH assay shows a greater antioxidant activity 83 % and lower IC50 about 2609.23 mg/mL for rGO/MgO nanocomposite. The cyclic voltammetry (CV) analysis was performed using carbon paste electrode in 1M KOH electrolyte. From CV studies, electrochemical reversibility at scan rate 10 mV/s (ER= 2.0810−6), proton diffusion co-efficient (D= 1.765 × 10−4) and capacitance (𝐶𝑠𝑝 = 173𝐹𝑔−1) has been improved significantly. The photodegradation of malachite green was carried out for rGO, MgO and rGO/MgO nanocomposite shows a greater degradation about 93% and follows 1st order kinetics. Further, sensing property of the synthesized material by utilizing Ascorbic acid (BS-A), Resorcinol (BS-R) and Uric acid (BS-U) exhibit a good sensing in the oxidation region.
In-vivo Calibration of Corneal Biomechanical Properties by Virtual Fields Method
Authors: Jannesari Mohammad , Kasprzak Henryk 
Published: September 2023

Abstract
Understanding corneal biomechanics plays an essential role in investigating ophthalmological procedures, such as refractive surgeries, and in diagnosing diseases like keratoconus. One of the most significant issues in corneal biomechanics is the in-vivo characterization of the human cornea. In this current research, the virtual fields method, based on the principle of virtual work, is employed to calibrate corneal biomechanical properties. To achieve this, corneal full-field deformation was derived for five healthy patients from images captured by the Corvis ST tonometer, using image processing techniques. Subsequently, by applying the principle of virtual work to the obtained data, the material parameters can be derived by minimizing a cost function that balances the virtual internal and external works at different time instances. To assess the method's ability to calibrate different models, two material models (isotropic and anisotropic) were selected, and their parameters were calculated. The results demonstrate that the virtual fields method can accurately characterize in-vivo corneal biomechanical properties using tonometry data, without the need to worry about the uniqueness of the solution. Moreover, the time required to calculate these properties is approximately five minutes, making the virtual fields method a suitable choice for clinical applications compared to other methods.
Cellular Patterning Alone Using Bioprinting Regenerates Articular Cartilage through Native-Like Cartilagenesis
Authors: Grottkau Brian E. , Hui Zhixin , Pang Yonggang 
Published: September 2023

Abstract

Few studies have proved that bioprinting itself helps recapitulate native tissue functions mainly because the bioprinted macro shape can rarely, if ever, influence cell function. This can be more problematic in bioprinting cartilage, generally considered more challenging to engineer. Here we show a new method to micro-pattern chondrocytes within bioprinted sub-millimeter articular micro-cartilage tissues (PA-MCTs) under the sole influence of bioprinted cellular patterns. A pattern scoring system is developed after over 600 bioprinted cellular patterns are analyzed. The top-scored pattern mimics that of the isogenous group in native articular cartilage. Under the sole influence of this pattern during PA-MCTs bio-assembling into macro-cartilage and repairing cartilage defects, chondrogenic cell phenotype is preserved, and cartilagenesis is initiated and maintained. Neocartilage tissues from individual and assembled PA-MCTs are comparable to native articular cartilage and superior to cartilage bioprinted with homogeneously distributed cells in morphology, biochemical components, cartilage-specific protein and gene expression, mechanical properties, integration with host tissues, zonation forming and stem cell chondrogenesis. PA-MCTs can also be used as osteoarthritic and healthy cartilage models for therapeutic drug screening and cartilage development studies. This cellular patterning technique could pave a new way for bioprinting to recapitulate native tissue functions via tissue genesis.
Unravelling the Amorphous Structure, Nanoscale Effects, and Crystallization Mechanism of GeTe Phase Change Memory Material
Authors: Wintersteller Simon , Yarema Olesya , Kumaar Dhananjeya , Schenk Florian M. , Safonova Olga , Abdala Paula M. , Wood Vanessa , Yarema Maksym 
Published: September 2023

Abstract

The reversible phase transitions in phase-change memory devices can switch on the order of nanoseconds, suggesting a close structural resemblance between the amorphous and crystalline phases. In contrast, the amorphous structure is generally assumed to consist of a highly random ordering of atoms, quite distant to its crystalline counterpart. This work uses in-situ high-temperature x-ray absorption spectroscopy (XAS) and theoretical calculations to quantify the amorphous structure of bulk and nanoscale GeTe. Based on XAS experiments, we develop a theoretical model of the amorphous GeTe structure, consisting of a disordered fcc-type Te sublattice and randomly arranged chains of Ge atoms in a tetrahedral coordination. Strikingly, our intuitive and scalable model provides an accurate description of the structural dynamics in phase-change memory materials, observed experimentally. Specifically, we present a detailed crystallization mechanism through the formation of an intermediate, partially stable, ‘ideal glass’ state and demonstrate differences between bulk and nanoscale GeTe leading to size-dependent crystallization temperature.
Indications for laparoscopic surgery at Al-Ahli Specialized Hospital in Damascus
Authors: Fadlallh Samer Awad , Fateh Ghaith Samer , Fawares Maamoun AL- , Al-Sakka Kanaan Salah Al-Din 
Published: September 2023

Abstract

Background: In addition to a shorter hospital stay and better cosmetic results, laparoscopic surgery offers fewer postoperative complications compared to traditional gynecological operations and, with the acquisition of experience, it has become an alternative surgical approach to the diagnosis and treatment of gynecological diseases.
Aim: The study aims to know the indications for laparoscopic surgery at Al-Ahli Specialized Hospital in Damascus.
Methods and material: The study included 130 patients who were admitted to Al-Ahly Specialized Hospital, where a cross-sectional study was conducted according to certain criteria, in the months of 4, 5, and 6 of the year 2023, where information was collected according to the research form that includes information (age, surgical history, medical history, diagnostic and therapeutic indication, diagnosis Final), and the data were analyzed using Spss-28 software.
Results: During the period in which we conducted our study, 130 laparoscopy procedures were performed for gynecological operations. The average age of the patients was (33.31 ± 9.391 years), and the patients mainly had secondary infertility (33.5%), primary infertility (25.8%), and pain. Abdominal and dorsal (11.6%), 4.6% of patients had spontaneous miscarriages, 21.5% of patients had mainly previous cesarean sections, 21.5% had mainly chronic salpingitis, 19.6% had tubo-pelvic adhesions, and 15 3% ovulatory dysfunction, and 5.8% tubo-ovarian adhesions. The adhesions were removed laparoscopically in 53.4%, methylene blue injections were performed in 10.7%, right and left ovarian cysts were removed (7.3% for each), and ovarian excavation (6.6%). and fibroid resection (1.7%).
conclusion: Laparoscopic surgery provides patients with a new option for intervention that provides a final diagnosis, and also provides fewer complications, a shorter stay in the hospital, and also contributes significantly to the treatment of gynecological diseases such as infertility of both types, fibroids, ectopic pregnancy and endometrial migration, through which the uterus can be partially removed. Or complete.
Thromboelastographic and Gene Polymorphism Bimodality Detection for
Dual Antiplatelet Aggregation Therapy in Individuals with
Clopidogrel-resistant Symptomatic Intracranial Artery Stenosis
Authors: Liu Longlong , Li Yan , Li Ying 
Published: September 2023

Background:
Recent research indicates that clopidogrel resistance is connected with a
patient's future ischemia risk, hence increasing the likelihood of recurrent ischemic cerebrovascular
disease. Thromboelastographic and clopidogrel gene polymorphism testing can be used to
see how a person responds to antiplatelet therapy and change the treatment plan accordingly.
This may be a good way to make antiplatelet aggregation therapy more effective and safer

Objective:
The objective of this study was to investigate the efficacy of dual antiplatelet aggregation
therapy in patients with symptomatic intracranial large artery stenosis being resistant to
clopidogrel tablets. The thromboelastographic and gene polymorphism bimodality detection
techniques were used to analyze the clopidogrel resistance influencing factors.

Methods:
89 patients with symptomatic intracranial large arterial stenosis who were admitted to
our hospital from February 2021 to February 2022 were selected, classified as large artery atherosclerotic
type by TOAST, and confirmed as having severe intracranial large arterial stenosis (70
% to 99 %) by magnetic resonance angiography (MRA), computed tomographic angiography
(CTA), and digital subtraction angiography (DSA). All patients were treated with dual antiplatelet
therapy with aspirin and clopidogrel, and thromboelastography and clopidogrel gene polymorphism
were monitored 1 week later.

Results:
44 of 89 patients were clopidogrel-resistant. Among 44 patients, 20 were ticagrelorresistant
and 24 were cilostazol-resistant. Clopidogrel had a resistance rate of 49.4%. The recurrence
of ischemic cerebrovascular disease in the three groups was statistically significant (P<0.05)
after 3 months of follow-up treatment, but bleeding (intracranial, gastrointestinal, respiratory, urinary,
and mucocutaneous) and dyspnea were not. The clopidogrel-resistant group had a higher
number of females, as well as higher levels of hypertension, diabetes, and platelet count than the
sensitive group (P<0.05), but there was no significant difference in age, smoking, alcohol consumption,
previous stroke, glycosylated haemoglobin, creatinine, or low-density cholesterol.

Conclusion:
Using thromboelastographic and gene polymorphism bimodality detection, we found
switching to ticagrelor antiplatelet aggregation therapy as better than switching to cilostazol in patients
with symptomatic intracranial large artery stenosis being resistant to clopidogrel tablets. The
results may be biased due to the study being a single-centre study and having a limited sample size.
Tuberculous Dactilitis in Young Male, a Rare Case
Authors: Yusdianto Adrian , Tantular Rezki , R. Sugiri Yani Jane , Rahayu Sartono Teguh , Rachma Erawati Dini , Setyo Yudhanto Hendy 
Published: September 2023

Introduction : Chylothorax is an uncommon medical condition caused by the accumulation of chylous fluid in the pleural space. Chylothorax has no predilection for sex or age. The prevalence after various cardiothoracic surgeries is 0.2% to 1%. Mortality and morbidity rates are around 10%. Respiratory distress may occur due to compression of the lung by the accumulated fluid. Management and approaches to treating the condition require multidisciplinary therapy, starting from non-pharmacological, pharmacological, to interventional management.
Case Report : A 57-year-old Man patient was referred to the emergency room with chief complaint of shortness of breath. Reduced breathing sound on both lung fields. No previous history of cancer or thoracic surgery were found. X-ray examination had found bilateral pleural effusion. Thoracocentesis and pleural fluid analysis was performed with total of 6800 cc serosanguinous, whitish fluid was extracted from both of the lung. The patient was diagnosed with chylothorax. Lymphangiography and embolization was performed on the leak on left thoracic duct (T10) from right lymph node. Antibiotic was also given to treat the community acquired pneumonia that could be one of the possible etiology on this patient. Dietary modification with low fat diet and Ocreotide was also given to this patient as one of the treatment modalities.
Discussion : The diagnosis of Chylothorax on this patient was established based on pleural fluid analysis and evidenced by lymphangiography examination by the presence of a leak in the thoracic lymphatic duct. Various modalities to diagnose this condition have been carried out with inconclusive results. Non-pharmacological, pharmacological and radiological interventions with embolization through lymphangiography are proven to be able to stop leaks and reduce symptoms in this patient.
Conclusion : Chyle leak to the pleural space may compress the lung and cause respiratory distress. Combinaton of thoracocentesis, embolization of the leakage, dietary intake modification and administration of ocreotide may help prevent further chylous fluid accumulation.