bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical initial cleavage patterns minimally impact rhesus macaque in vitro embryo morphokinetics and embryo outgrowth development
Authors: Schmidt Jenna Kropp , Block Lindsey N , Jones Kathryn M , Hinkle Hayly M , Mean Katherine D , Bowman Brittany D , Makulec Allison T , Golos Thaddeus G 
Published: September 2023

Abstract
Embryo morphokinetic analysis through time-lapse embryo imaging is envisioned as a method to improve selection of developmentally competent embryos. Morphokinetic analysis could be utilized to evaluate the effects of experimental manipulation on pre-implantation embryo development. The objectives of this study were to establish a normative morphokinetic database for in vitro fertilized rhesus macaque embryos and to assess the impact of atypical initial cleavage patterns on subsequent embryo development and formation of embryo outgrowths. The cleavage pattern and the timing of embryo developmental events were annotated retrospectively for unmanipulated in vitro fertilized rhesus macaque blastocysts produced over four breeding seasons. Approximately 50% of the blastocysts analyzed had an abnormal early cleavage event. The time to the initiation of embryo compaction and the time to completion of hatching was significantly delayed in blastocysts with an abnormal early cleavage event compared to blastocysts that had cleaved normally. Embryo hatching, attachment to an extracellular matrix, and growth during the implantation stage in vitro was not impacted by the initial cleavage pattern. These data establish normative morphokinetic parameters for in vitro fertilized rhesus macaque embryos and suggest that cleavage anomalies may not impact embryo implantation rates following embryo transfer.
Local absorbing boundary conditions on fixed domains give order-one errors for high-frequency waves
Authors: Galkowski Jeffrey , Lafontaine David , Spence Euan A 
Published: September 2023

Abstract
We consider approximating the solution of the Helmholtz exterior Dirichlet problem for a nontrapping obstacle, with boundary data coming from plane-wave incidence, by the solution of the corresponding boundary value problem where the exterior domain is truncated and a local absorbing boundary condition coming from a Padé approximation (of arbitrary order) of the Dirichlet-to-Neumann map is imposed on the artificial boundary (recall that the simplest such boundary condition is the impedance boundary condition). We prove upper- and lower-bounds on the relative error incurred by this approximation, both in the whole domain and in a fixed neighbourhood of the obstacle (i.e., away from the artificial boundary). Our bounds are valid for arbitrarily-high frequency, with the artificial boundary fixed, and show that the relative error is bounded away from zero, independent of the frequency, and regardless of the geometry of the artificial boundary.
Maximum norm error bounds for the full discretization of nonautonomous wave equations
Authors: Dörich Benjamin , Leibold Jan , Maier Bernhard 
Published: September 2023

Abstract
In the present paper, we consider a specific class of nonautonomous wave equations on a smooth, bounded domain and their discretization in space by isoparametric finite elements and in time by the implicit Euler method. Building upon the work of Baker and Dougalis (1980, On the ${L}^{\infty }$-convergence of Galerkin approximations for second-order hyperbolic equations. Math. Comp., 34, 401–424), we prove optimal error bounds in the $W^{1,\infty } \times L^\infty $-norm for the semidiscretization in space and the full discretization. The key tool is the gain of integrability coming from the inverse of the discretized differential operator. For this, we have to pay with (discrete) time derivatives on the error in the $H^{1} \times L^2$-norm, which are reduced to estimates of the differentiated initial errors. To confirm our theoretical findings, we also present numerical experiments.
An Algorithm to Compute the Fundamental Classes of Spin Components of Strata of Differentials
Authors: Wong Yiu Man 
Published: September 2023

Abstract
We construct an algorithm for computing the cycle classes of the spin components of a stratum of differentials in the moduli space of stable curves $\overline {\mathcal {M}}_{g,n}$. In addition, we implement it within the Sage package admcycles. Our main strategy is to reconstruct these cycles by their restrictions to the boundary of $\overline {\mathcal {M}}_{g,n}$ via clutching maps. These restrictions can be computed recursively by smaller dimensional spin classes and determine the original class via a certain system of linear equations. To study the spin parities on the boundary of a stratum of differentials of even type, we make use of the moduli space of multi-scale differentials introduced in [4]. As an application of our algorithm, one can verify a conjecture on spin double ramification cycles stated in [18] in many examples, by using the results computed by our algorithm.
A chatbot for hypertension self-management support: user-centered design, development, and usability testing
Authors: Griffin Ashley C , Khairat Saif , Bailey Stacy C , Chung Arlene E 
Published: September 2023

Abstract

Objectives
Health-related chatbots have demonstrated early promise for improving self-management behaviors but have seldomly been utilized for hypertension. This research focused on the design, development, and usability evaluation of a chatbot for hypertension self-management, called “Medicagent.”

Materials and Methods
A user-centered design process was used to iteratively design and develop a text-based chatbot using Google Cloud’s Dialogflow natural language understanding platform. Then, usability testing sessions were conducted among patients with hypertension. Each session was comprised of: (1) background questionnaires, (2) 10 representative tasks within Medicagent, (3) System Usability Scale (SUS) questionnaire, and (4) a brief semi-structured interview. Sessions were video and audio recorded using Zoom. Qualitative and quantitative analyses were used to assess effectiveness, efficiency, and satisfaction of the chatbot.

Results
Participants (n = 10) completed nearly all tasks (98%, 98/100) and spent an average of 18 min (SD = 10 min) interacting with Medicagent. Only 11 (8.6%) utterances were not successfully mapped to an intent. Medicagent achieved a mean SUS score of 78.8/100, which demonstrated acceptable usability. Several participants had difficulties navigating the conversational interface without menu and back buttons, felt additional information would be useful for redirection when utterances were not recognized, and desired a health professional persona within the chatbot.

Discussion
The text-based chatbot was viewed favorably for assisting with blood pressure and medication-related tasks and had good usability.

Conclusion
Flexibility of interaction styles, handling unrecognized utterances gracefully, and having a credible persona were highlighted as design components that may further enrich the user experience of chatbots for hypertension self-management.
Pharmacokinetic Analysis of Intravenous Push Cefepime in Burn Patients with Augmented Renal Clearance
Authors: Hill David M , Yang Bing , Laizure S Casey , Boucher Bradley , Swanson Joseph M , Wood G Christopher , Hickerson William L , Liu Xiangxia , Velamuri Sai R 
Published: September 2023

Abstract
Patients with augmented renal clearance (ARC) are a subset of critically ill patients including burn patients that exhibit increased renal elimination of medications beyond that of similarly injured patients. Currently approved maximum regimens of medications primarily eliminated by the kidney, such as cefepime (&gt;90% unchanged in the urine), may be inadequate (eg, compromising the bactericidal activity of cefepime) in patients with ARC. Due to recent resource limitations, centers have changed infusion practices of commonly prescribed medications to intravenous push (IVP), potentially exacerbating the problem of maintaining bactericidal cefepime concentrations. The hypothesis of the study was patients with ARC are not currently achieving adequate target attainment, when receiving cefepime 2 g every 8 h IVP. Eight blood samples were collected from each patient, and concentrations measured via LC–MS/MS. WinNonlin (version 8.3) was used to estimate the pharmacokinetic parameters of cefepime and simulate plasma concentrations of cefepime in each of the ten subjects. Simulations of cefepime plasma concentrations produced by a 2 g dose given every 8 h and a 1 g dose given every 4 h were performed and the time above a MIC of 4 mg/L, 8 mg/L, and 16 mg/L compared. The 2 g every 8 h regimen remained above the breakpoints for 92%, 85%, and 71% of the dosing interval, respectively. The 1 g every 4 h regimen remained above the same breakpoints at a frequency of 100%, 99%, and 92% of the dosing interval. Giving cefepime 1 g every 4 h is a simple approach to increase the likelihood of maintaining the optimal bactericidal activity of cefepime in patients with ARC.
Hypoxia reduces thermotolerance in the postlarvae of the whiteleg shrimp Penaeus vannamei Boone, 1931 (Decapoda: Dendrobranchiata: Penaeidae)
Authors: Ulaje Sergio A , Sicard M Teresa , Racotta Ilie S , Rojo-Arreola Liliana , Lluch-Cota Salvador E 
Published: September 2023

Abstract
The thermal responses and tolerance of organisms can be influenced by synergistic interactions with other environmental stresses. Although the heat sensitivity of the whiteleg shrimp (Penaeus vannamei Boone, 1931 = Litopenaeus vannamei) has been extensively researched, little is known about how hypoxia impacts the thermal tolerance of the species. We assessed the thermotolerance of P. vannamei postlarvae under combined hyperthermia and hypoxia conditions. Simultaneous hypoxia significantly decreased the thermotolerance (LT50) of the postlarvae at temperatures close to the upper thermal limit of the species.
The revision hip arthroscopy complex: capsular deficiency, labral deficiency, femoral over-resection and adhesions can result in good survivorship with revision hip arthroscopy
Authors: Melugin Heath P , Comfort Spencer M , Shelton Trevor S , Day Hannah K , Ruzbarsky Joseph J , Dornan Grant J , Philippon Marc J 
Published: September 2023

ABSTRACT
To evaluate the patient-reported outcomes (PROs) and survivorship of combined arthroscopic hip labral reconstruction/augmentation, capsular reconstruction, femoral neck remplissage and lysis of adhesions. Patients ≥18 years old who underwent this combination of procedures during revision hip arthroscopy and were eligible for minimum 2-year follow-up were identified. PRO scores including Hip Outcome Score (HOS)-Activities of Daily Living scale, HOS-Sports scale, modified Harris Hip Score, Short Form 12, and Western Ontario & McMaster Universities Osteoarthritis Index, patient satisfaction and failure rates were analyzed. Seven patients (5 females and 2 males) with average age of 45.0 ± 5.2 (range: 40–54 years) met inclusion criteria. Patients had a median of 1 (range: 1–3) prior hip surgery at an outside institution. All patients had previously undergone femoral osteoplasty, and 85% (6/7) of patients had a labral repair performed. Four patients had no capsule closure performed in their prior procedures. Six patients were available for minimum 2-year follow-up. Two patients converted to total hip arthroplasty: one patient with four prior hip arthroscopies and the other had advanced osteoarthritis with outerbridge grade 3/4 defects requiring microfracture. Mean patient satisfaction was 7 (range: 2–9). At mean follow-up of 3 years, most patients who underwent the combination of labral reconstruction, capsular reconstruction, femoral neck remplissage and lysis of adhesions during revision hip arthroscopy demonstrated improved PROs. This salvage procedure has the potential to restore hip function in patients who have failed an initial hip arthroscopy procedure. In patients with these pathologies present and concomitant joint space narrowing, a total hip arthroplasty may be a more appropriate salvage option.
Does pelvic tilt change with a peri-acetabular osteotomy?
Authors: Verhaegen Jeroen C F , Dedeoğulları Emin Süha , Horton Isabel S , Beaulé Paul E , Grammatopoulos George 
Published: September 2023

ABSTRACT
Change in pelvic tilt (PT) during and after peri-acetabular osteotomy (PAO) is important for surgical planning. The aims of this study were to (i) determine how PT varies throughout the course of treatment in patients undergoing PAO, (ii) test what factors influence the change in PT and (iii) assess whether changes in PT influenced achieved correction. This is an retrospective, single-centre, consecutive case series of 111 patients treated with PAO for global (n = 79), posterior (n = 49) or anterior dysplasia (n = 6) (mean age: 27.3 ± 7.7 years; 85% females). PT was determined on supine, anteroposterior pelvic radiographs pre-, intra-, 1 day, 6 weeks and 1 year post-operatively, using the sacro-femoral-pubic (SFP) angle, a validated, surrogate marker of PT. An optimal acetabular correction was based on the lateral centre-edge angle (25°–40°), acetabular index (−5° to 10°) and cross-over ratio (&lt;20%). There was a significant difference across pre- (70.1° ± 4.8°), 1-day (71.7° ± 4.3°; P &lt; 0.001) and early post-operative SFP (70.6° ± 4.7°; P = 0.004). The difference in SPF between pre-operative and 1-year post-operative was −0.5° ± 3.1° (P = 0.043), with 9% of cases having a difference of &gt;5°. The difference in SFP did not correlate with age, sex, body mass index, type of dysplasia or achievement of optimal acetabular correction (P = 0.1–0.9). In the early post-operative period, PT is reduced, leading to a relative appearance of acetabular retroversion, which gradually corrects and is restored by annual follow-up. The degree of change in PT during PAO did not adversely affect fragment orientation. PT does not significantly change in most patients undergoing PAO and therefore does not appear to be a compensatory mechanism.
Changes in cancer-related mortality during the COVID-19 pandemic in the United States
Authors: Fedeli Ugo , Barbiellini Amidei Claudio , Han Xuesong , Jemal Ahmedin 
Published: September 2023

Abstract
Few studies have examined cancer-related mortality overall, never mind select cancer types, during the COVID-19 pandemic. Data on cancer-related mortality (any mention in death certificates, multiple causes of death approach) was extracted from the US Centers for Disease Control and Prevention WONDER database. Changes in trends for age-standardized mortality rates through 1999-2021 were assessed by Joinpoint analysis. In total, 1 379 643 cancer-related deaths were registered in 2020-2021, with cancer selected as the underlying cause in 88%. After 2 decades of decline, age-standardized cancer-related mortality increased from 2019 to 2021 for all cancers (annual percentage change = 1.6%, 95% confidence interval = 0.6% to 2.6%), especially for prostate cancer (annual percentage change = 5.1%, 95% confidence interval = 2.2% to 8.2%) and hematologic cancers (annual percentage change = 4.8%, 95% confidence interval = 3.1% to 6.6%). Sharp peaks in cancer-related deaths for many cancer sites were observed during pandemic waves in both 2020 and 2021, mostly attributed to COVID-19 as the underlying cause. Multiple causes of death analyses are warranted to fully assess the impact of the pandemic on cancer-related mortality.
Fosphenytoin alleviates subacute herpetic neuralgia and postherpetic neuralgia in mice
Authors: Takasaki Ichiro , Inoue Arata , Yoshida Aoi , Shiraki Kimiyasu , Kitada Yoshimi , Arai Saori 
Published: September 2023

Abstract

Objective
This study aimed to explore the analgesic effects of fosphenytoin (fPHT) on pain-related behaviours in mouse models of subacute herpetic neuralgia (subAHN) and postherpetic neuralgia (PHN). SubAHN refers to pain experienced immediately after the disappearance of a skin rash, while PHN is characterized by persistent pain long after skin rash resolution.

Methods
Our experimental approach involved the induction of acute herpes zoster-like skin lesions and pain-related responses (mechanical allodynia and hyperalgesia) in the hind paws of mice through cutaneous inoculation with herpes simplex virus type 1 (HSV-1). Subsequently, subAHN and PHN developed in the mice.

Key findings
Intravenous administration of fPHT (30 mg/kg) effectively mitigated HSV-1-induced subAHN and PHN. The suppressive effect of fPHT on subAHN was comparable to that of pregabalin (3 mg/kg, oral), a commonly used positive control. However, fPHT exhibited a slightly more potent effect than pregabalin in alleviating PHN.

Conclusions
These findings suggest that intravenous fPHT could serve as a promising alternative for pain relief in both subAHN and PHN.
Effector-specific motor simulation supplements core action recognition processes in adverse conditions
Authors: Vannuscorps Gilles , Caramazza Alfonso 
Published: September 2023

AbstractObserving other people acting activates imitative motor plans in the observer. Whether, and if so when and how, such ‘effector-specific motor simulation’ contributes to action recognition remains unclear. We report that individuals born without upper limbs (IDs)—who cannot covertly imitate upper-limb movements—are significantly less accurate at recognizing degraded (but not intact) upper-limb than lower-limb actions (i.e. point-light animations). This finding emphasizes the need to reframe the current controversy regarding the role of effector-specific motor simulation in action recognition: instead of focusing on the dichotomy between motor and non-motor theories, the field would benefit from new hypotheses specifying when and how effector-specific motor simulation may supplement core action recognition processes to accommodate the full variety of action stimuli that humans can recognize.
Embedding implementation science in the research pipeline
Authors: Zullig Leah L , Drake Connor , Check Devon K , Brunkert Thekla , Deschodt Mieke , Olson Melvin (Skip) , De Geest Sabina 
Published: September 2023

Abstract
Clinical and health services researchers seek to discover effective programs, practices, and interventions to improve people’s health. The current paradigm for evidence generation is incremental and misaligned to translate evidence-based discoveries into real-world settings. This persistent challenge are “valleys of death” that represent missed opportunities and preventable missteps to actually use scientific advancements in real-world clinical settings where they can improve health and well-being (De Geest S, Zúñiga F, Brunkert T et al. Powering Swiss health care for the future: implementation science to bridge “the valley of death”. 2020;150:w20323). Only one in seven of evidence-based interventions is ever implemented. It is after an average of 17 years. We propose embedding the principles of implementation science throughout the research pipeline, from discovery to adoption, to efficiently translate discoveries into real-world contexts (Balas EA, Boren SA. Managing clinical knowledge for health care improvement. 2000;9:65–70). We outline implications for capacity building, including composition of the research team, study design, and competencies that could bolster the value proposition of implementation science. We describe a research paradigm that recognizes scientists’ responsibility to ensure their discoveries be translated into real-world settings.
Surgical Intervention for Primary B-cell Lymphoma of the Spine
Authors: Gendreau Julian L. , Patel Neal , Brown Nolan J. , Lee Seung Jin , Sahyouni Ronald , Chan Andrew K. , Clifton William E. , Chen Selby 
Published: September 2023

Study Design:
Systematic review and meta-analysis.

Objective:
To perform a systematic review of the clinical symptoms, radiographic findings, and outcomes after spinal decompression in B-cell lymphoma.

Summary of Background Data:
B-cell lymphoma is a potential cause of spinal cord compression that presents ambiguously with nonspecific symptoms and variable imaging findings. Surgical decompression is a mainstay for both diagnosis and management, especially in patients with acute neurological deficits; however, the efficacy of surgical intervention compared with nonoperative management is still unclear.

Methods:
The databases of Medline, PubMed, and the Cochrane Database of Systemic Reviews were queried for all articles reporting spinal B-cell lymphoma. Data on presenting symptoms, treatments, survival outcomes, and histologic markers were extracted. Using the R software “survival” package, we generated bivariate and multivariate Cox survival regression models and Kaplan-Meier curves.

Results:
In total, 65 studies were included with 72 patients diagnosed with spinal B-cell lymphoma. The mean age was 56.22 (interquartile range: 45.00–70.25) with 68% of patients being males and 4.2% of patients being immunocompromised. Back pain was the most common symptom (74%), whereas B symptoms and cauda equina symptoms were present in 6% and 29%, respectively. The average duration of symptoms before presentation was 3.81 months (interquartile range: 0.45–3.25). The most common location was the thoracic spine (53%), with most lesions being hyperintense (28%) on T2 magnetic resonance imaging. Surgical resection was performed in 83% of patients. Symptoms improved in 91% of patients after surgery and in 80% of patients treated nonoperatively. For all 72 patients, the overall survival at 1 and 5 years was 85% (95% CI: 0.749–0.953; n = 72) and 66% (95% CI: 0.512–0.847; n = 72), respectively.

Conclusion:
Although surgery is usually offered in patients with acute spinal cord compression from B-cell lymphoma, chemotherapy and radiation alone offer a hopeful alternative to achieve symptomatic relief, particularly in patients who are unable to undergo surgery.