bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats
Authors: Samir Rania , Hassan Ekrami A. , Saber Abdullah A. , Haneen David S. A. , Saleh Eman M. 
Published: March 2023

Abstract
Doxorubicin (DOX) is a potent anticancer drug with adverse cardiotoxic effects. Alginates are multifunctional biopolymers and polyelectrolytes derived from the cell walls of brown seaweeds. They are nontoxic, biocompatible, and biodegradable, and hence, utilized in several biomedical and pharmaceutical applications. Here, we investigated the potential cardioprotective effect of thermally treated sodium alginate (TTSA), which was extracted and purified from the seaweed Sargassum aquifolium, in treating acute DOX cardiotoxicity and apoptotic pathways in rats. UV–visible spectroscopy, Fourier-transform infrared, and nuclear magnetic resonance (1H–NMR) spectroscopy techniques were used to characterize TTSA. CK-MB and AST levels in sera samples were determined. The expression levels of Erk-2 (MAPK-1) and iNOS genes were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression levels of Erk-2, anti-apoptotic p53, and caspase-3 were analyzed using western blotting and ELISA. For the in vivo studies, sixty rats were randomly divided equally into six groups and treated with DOX, followed by TTSA. We revealed that treatment with TTSA, which has low molecular weight and enhanced antioxidant properties, improved DOX-mediated cardiac dysfunction and alleviated DOX-induced myocardial apoptosis. Furthermore, TTSA exhibited a cardioprotective effect against DOX-induced cardiac toxicity, indicated by the increased expression of MAPK-1 (Erk2) and iNOS genes, which are implicated in the adaptive responses regulating DOX-induced myocardial damage. Moreover, TTSA significantly (p < 0.05) suppressed caspase-3 and upregulated anti-apoptotic protein p53 expression. TTSA also rebalanced the cardiomyocyte redox potential by significantly (p < 0.05) increasing the levels of endogenous antioxidant enzymes, including catalase and superoxide dismutase. Our findings suggest that TTSA, particularly at a dose of 400 mg/kg b.w., is a potential prophylactic supplement for treating acute DOX-linked cardiotoxicity.
Work engagement and employee satisfaction in the practice of sustainable human resource management – based on the study of Polish employees
Authors: Sypniewska Barbara , Baran Małgorzata , Kłos Monika 
Published: March 2023

AbstractSustainable human resource management (SHRM) views employees as a very important resource for the organisation, while paying close attention to their preferences, needs, and perspectives. The individual is an essential element of SHRM. The article focuses on analyzing selected SHRM issues related to the individual employee's level of job engagement and employee satisfaction. The main objective of our study was to identify individual-level correlations between factors affecting employee satisfaction, such as: workplace well-being, employee development, employee retention, job engagement, and employee satisfaction. Based on the results of a systematic literature review, we posed the following research question: is there any relation between factors affecting employee satisfaction (employee workplace well-being, employee development, employee retention, work engagement) and employee satisfaction in the SHRM context? To answer the research question, we have conducted a quantitative study on the sample of 1051 employees in companies in Poland and posed five hypotheses (H1-H5). The research findings illustrate that higher level of employee workplace well-being (H1), employee development, (H2), employee retention (H3) was related to higher level of employee engagement (H4), which in turn led to higher level of employee satisfaction. The results show the mediating role of employee engagement in the relationship between workplace well-being, employee development, employee retention, and employee satisfaction (H5). The presented results contribute to the development of research on work engagement and job satisfaction in the practice of SHRM. By examining the impact of individual-level factors on job satisfaction, we explain which workplace factors should be addressed to increase an employee satisfaction and work engagement. The set of practical implications for managers implementing SHRM in the organization is discussed at the end of the paper.
Repeated applications of farm dairy effluent treated with poly-ferric sulphate did not adversely affect soil phosphorus availability, P fractions and pasture response — a 4-year field plot study
Authors: Che Xueying , Di Hong J. , Cameron Keith C. , Dodd Rosalind 
Published: March 2023

Abstract
Purpose
Land application of farm dairy effluent (FDE) can cause phosphorus contamination of freshwater due to its high nutrient content especially phosphorus (P) in the animal dung. A novel FDE treatment technology has been developed that uses poly-ferric sulphate (PFS) to treat the FDE and recycle water for washing farmyard and reduce the risk of water pollution from P leaching from through the soil. It is important that the application of PFS-treated FDE (TE) does not cause any adverse impacts on soil fertility or plant growth when the TE is applied to the soil.

Materials and methods
A multi-year field plot study was conducted to determine the effect of repeat applications of FDE and PFS-treated FDE (TE) on soil P availability, P fractionations, plant yield and nutrient uptake. Eight applications of untreated FDE, TE and water as control were applied to replicated soil plots over the period of 4 years. The soil samples were collected on 1 December 2020, and nine pasture samples were harvested during the 2021–2022 dairy milking season. Measurements included soil chemical properties, soil phosphorous fractionations, plant biomass and plant phosphorus and nitrogen uptake.

Results and discussion
The results indicated that the majority of soil fertility indices and soil P fractions had no significant difference between the FDE and TE applications, with the exception of labile P which was significantly higher in the TE (122.7 mg kg−1) than in the FDE treatments (103.0 mg kg−1) at 0–10-cm soil depth and was also significantly higher in the TE (114.6 mg kg−1) than in the FDE treatments (74.0 mg kg−1) at 10–20-cm soil depth. Similarly, plant P uptakes and dry matter yields were also the same between the TE and FDE treatments with the average of being 54.4 kg P ha−1 and 12.8 t ha−1, respectively.

Conclusions
Repeated applications of PFS-treated FDE had no adverse effect on soil P availability or plant growth when compared to untreated FDE application and had the potential to benefit soil fertility compared to control.
Was motiviert Frauen zur Teilnahme am Mammographiescreening? Ergebnisse einer qualitativen Analyse von Interviews
Authors: Gummersbach Elisabeth , Fuchs Angela , Lubisch Diana , in der Schmitten Jürgen , Pentzek Michael , Leve Verena 
Published: March 2023

Zusammenfassung
Einleitung
Die Teilnahmerate am Mammographiescreening beträgt derzeit ca. 49 %. Über die Gründe für Frauen, am Screening teilzunehmen, ist bisher zu wenig bekannt.

Material und Methoden
Für eine qualitative Studie wurden aus den Teilnehmerinnen einer Fragebogenstudie zum Einfluss verschiedener Informationsbroschüren auf die Teilnahmebereitschaft 8 Frauen für Interviews ausgewählt. Die Frauen wurden nach den Kriterien Teilnahmebereitschaft (6 ja, 2 nein), Bildung (6 hoch, 2 niedrig) und Entscheidungssicherheit (6 hoch, 2 niedrig) ausgewählt und im Jahr 2014 in problemzentrierten Einzelinterviews befragt. Sequenzen der Interviewtranskripte wurden in multidisziplinären Teams inhaltsanalytisch ausgewertet.

Ergebnisse
Alle interviewten Frauen hatten Mammographieerfahrung. Es wurden übergreifende Themen in sechs Kategorien identifiziert: Pflichtgefühl, Autonomie, Zweifel, Unsicherheit, Arzt/Ärztin, Institution. Die Frauen sahen in der Screeningteilnahme die Chance, einer möglichen Bedrohung durch Brustkrebs zu entgehen. Erfahrungen mit Brustkrebs im Umfeld beeinflussten ihre Entscheidung. Einer selbstverantwortlichen Entscheidungsbildung wurde ein hoher Stellenwert zugesprochen, andererseits folgten sie dem Rat ihres Arztes/ihrer Ärztin. Bei der Durchführung des Screenings fühlten sie sich einer unpersönlichen und schmerzhaften Maschinerie ausgesetzt.

Schlussfolgerungen
Frauen treffen ihre Entscheidung, am Screening teilzunehmen oder nicht, eher auf der emotionalen Ebene. Um ihnen eine informierte Entscheidung zu ermöglichen, sollten in einem ärztlichen Gespräch neben sachlichen Informationen ihre Vorstellungen und Erfahrungen in Bezug auf das Mammographiescreening ergebnisoffen besprochen werden.
Institutional Overlap in Global Governance and the Design of Intergovernmental Organizations
Authors: Reinsberg Bernhard , Westerwinter Oliver 
Published: March 2023

AbstractHow does the increasingly dense network of overlapping institutions in global governance affect the design of intergovernmental organizations (IGOs)? We argue that institutional overlap can unleash mimicking dynamics whereby states design new IGOs using the design of existing organizations that engage in similar issue areas and perform similar governance tasks for similar member states as templates. Using design templates from the reference group of overlapping institutions is a strategy for boundedly rational designers in situations of complexity because it reduces uncertainty and lowers the costs of identifying suitable institutional solutions. Overlap therefore increases the design similarity between new and pre-existing IGOs, specifically where pre-existing organizations have institutional designs that made them endure. Introducing a new measure of institutional overlap in global governance and new data on the design and governance tasks of the 534 IGOs from the Correlates of War Project, we corroborate our argument using regression analyses. Our results hold important lessons for theories of institutional design, regime complexity, and global governance more broadly.
A Minimum Bayes Factor Based Threshold for Activation Likelihood Estimation
Authors: Costa Tommaso , Liloia Donato , Cauda Franco , Fox Peter T. , Mutta Francesca Dalla , Duca Sergio , Manuello Jordi 
Published: March 2023

AbstractActivation likelihood estimation (ALE) is among the most used algorithms to perform neuroimaging meta-analysis. Since its first implementation, several thresholding procedures had been proposed, all referred to the frequentist framework, returning a rejection criterion for the null hypothesis according to the critical p-value selected. However, this is not informative in terms of probabilities of the validity of the hypotheses. Here, we describe an innovative thresholding procedure based on the concept of minimum Bayes factor (mBF). The use of the Bayesian framework allows to consider different levels of probability, each of these being equally significant. In order to simplify the translation between the common ALE practice and the proposed approach, we analised six task-fMRI/VBM datasets and determined the mBF values equivalent to the currently recommended frequentist thresholds based on Family Wise Error (FWE). Sensitivity and robustness toward spurious findings were also analyzed. Results showed that the cutoff log10(mBF) = 5 is equivalent to the FWE threshold, often referred as voxel-level threshold, while the cutoff log10(mBF) = 2 is equivalent to the cluster-level FWE (c-FWE) threshold. However, only in the latter case voxels spatially far from the blobs of effect in the c-FWE ALE map survived. Therefore, when using the Bayesian thresholding the cutoff log10(mBF) = 5 should be preferred. However, being in the Bayesian framework, lower values are all equally significant, while suggesting weaker level of force for that hypothesis. Hence, results obtained through less conservative thresholds can be legitimately discussed without losing statistical rigor. The proposed technique adds therefore a powerful tool to the human-brain-mapping field.
Closed Embedded Self-shrinkers of Mean Curvature Flow
Authors: Riedler Oskar 
Published: March 2023

AbstractIn this article, we show the existence of closed embedded self-shrinkers in $${\mathbb {R}}^{n+1}$$

R

n
+
1

that are topologically of type $$S^1\times M$$

S
1

×
M

, where $$M\subset S^n$$

M
⊂

S
n

is any isoparametric hypersurface in $$S^n$$

S
n

for which the multiplicities of the principle curvatures agree. This yields new examples of closed self-shrinkers, for example self-shrinkers of topological type $$S^1\times S^k\times S^k\subset {\mathbb {R}}^{2k+2}$$

S
1

×

S
k

×

S
k

⊂

R

2
k
+
2

for any k. If the number of distinct principle curvatures of M is one, the resulting self-shrinker is topologically $$S^1\times S^{n-1}$$

S
1

×

S

n
-
1

and the construction recovers Angenent’s shrinking doughnut (Angenent in Shrinking doughnuts, Birkhäuser, Boston, pp 21–38).
Not Only WEIRD but “Uncanny”? A Systematic Review of Diversity in Human–Robot Interaction Research
Authors: Seaborn Katie , Barbareschi Giulia , Chandra Shruti 
Published: March 2023

AbstractCritical voices within and beyond the scientific community have pointed to a grave matter of concern regarding who is included in research and who is not. Subsequent investigations have revealed an extensive form of sampling bias across a broad range of disciplines that conduct human subjects research called “WEIRD”: Western, Educated, Industrial, Rich, and Democratic. Recent work has indicated that this pattern exists within human–computer interaction (HCI) research, as well. How then does human–robot interaction (HRI) fare? And could there be other patterns of sampling bias at play, perhaps those especially relevant to this field of study? We conducted a systematic review of the premier ACM/IEEE International Conference on Human-Robot Interaction (2006–2022) to discover whether and how WEIRD HRI research is. Importantly, we expanded our purview to other factors of representation highlighted by critical work on inclusion and intersectionality as potentially underreported, overlooked, and even marginalized factors of human diversity. Findings from 827 studies across 749 papers confirm that participants in HRI research also tend to be drawn from WEIRD populations. Moreover, we find evidence of limited, obscured, and possible misrepresentation in participant sampling and reporting along key axes of diversity: sex and gender, race and ethnicity, age, sexuality and family configuration, disability, body type, ideology, and domain expertise. We discuss methodological and ethical implications for recruitment, analysis, and reporting, as well as the significance for HRI as a base of knowledge.
Mind Perception in HRI: Exploring Users’ Attribution of Mental and Emotional States to Robots with Different Behavioural Styles
Authors: Cucciniello Ilenia , Sangiovanni Sara , Maggi Gianpaolo , Rossi Silvia 
Published: March 2023

AbstractTheory of Mind is crucial to understand and predict others’ behaviour, underpinning the ability to engage in complex social interactions. Many studies have evaluated a robot’s ability to attribute thoughts, beliefs, and emotions to humans during social interactions, but few studies have investigated human attribution to robots with such capabilities. This study contributes to this direction by evaluating how the cognitive and emotional capabilities attributed to the robot by humans may be influenced by some behavioural characteristics of robots during the interaction. For this reason, we used the Dimensions of Mind Perception questionnaire to measure participants’ perceptions of different robot behaviour styles, namely Friendly, Neutral, and Authoritarian, which we designed and validated in our previous works. The results obtained confirmed our hypotheses because people judged the robot’s mental capabilities differently depending on the interaction style. Particularly, the Friendly is considered more capable of experiencing positive emotions such as Pleasure, Desire, Consciousness, and Joy; conversely, the Authoritarian is considered more capable of experiencing negative emotions such as Fear, Pain, and Rage than the Friendly. Moreover, they confirmed that interaction styles differently impacted the perception of the participants on the Agency dimension, Communication, and Thought.
Deep Learning-Based Modeling of Drug–Target Interaction Prediction Incorporating Binding Site Information of Proteins
Authors: D’Souza Sofia , Prema K. V. , Balaji S. , Shah Ronak 
Published: March 2023

AbstractChemogenomics, also known as proteochemometrics, covers various computational methods for predicting interactions between related drugs and targets on large-scale data. Chemogenomics is used in the early stages of drug discovery to predict the off-target effects of proteins against therapeutic candidates. This study aims to predict unknown ligand–target interactions using one-dimensional SMILES as inputs for ligands and binding site residues for proteins in a computationally efficient manner. We first formulate a Deep learning CNN model using one-dimensional SMILES for drugs and motif-rich binding pocket subsequences of proteins as inputs. We evaluate and compare the proposed deep learning model trained on expert-based features against shallow feature-based machine learning methods. The proposed method achieved better or similar performance on the MSE and AUPR metrics than the shallow methods. Additionally, We show that our deep learning model, DeepPS is computationally more efficient than the deep learning model trained on full-length raw sequences of proteins. We conclude that a beneficial research approach would be to integrate structural information of proteins for modeling drug-target interaction prediction of large datasets for more interpretability, high throughput, and broad applicability.
Graphical abstract
Blatticomposting of Food Waste, Production Estimates, Chemical Composition and CO2 Emissions Savings: A Case Study
Authors: Patón D. , García-Gómez J. C. 
Published: March 2023

AbstractHalf of the organic waste generated by mankind is compostable. Many of the traditional methods of food waste treatment generate pernicious effects on ecosystems, such as leachates, greenhouse gases, pathogenic microorganisms or odors. Three cockroach species that are widespread as live food for feeding exotic animals (mainly reptiles) due to their high growth rates, waste consumption, production and quality of blatticompost: the Madagascar hissing cockroach (Aeluropoda insignis Butler), the Guyana spotted cockroach (Blaptica dubia Serville) and the ivory cockroach (Eublaberus sp.) has been evaluated. Neither the weight–length ratios (W–L) nor the body condition index (Krel) of the three species studied were statistically different between the control and organic waste treatment groups. Average intakes per animal per day were 0.93 g in Aeluropoda, 2.22 g in Blaptica and 2.58 g in Eublaberus. Blatticompost production rates were 0.11, 0.75 and 0.52 g / animal*day, respectively. Taking into account the differences in size and density of individuals, this implies an average waste consumption of 1015.9 g/m2*day, of which 26.7% would be transformed into blatticompost considering the three species together. This is equivalent to 304.8 mt/ha*month of food waste recycled, a blatticompost production of 81.4 mt/ha*month and an estimated greenhouse gas emission savings of 817.2 mt/ha*month. Results indicate that any of the three species studied would be a viable alternative, although the ivory cockroach (Eublaberus sp.) presents ideal characteristics. The massive use of this species in the large-scale treatment of organic waste is proposed. Given the enormous advantages of this treatment and the zero environmental costs (absence of invasive character) could be necessary to adapt the legislation of the European Community to include blatticomposting as a suitable waste treatment as it is done in other parts of the world.
Graphical Abstract
Where Have We Been and Where Are We Going with Mindfulness in Schools?
Authors: Weare Katherine 
Published: March 2023

AbstractThis is a commentary on a paper by Roeser et al. entitled “Beyond all splits: Envisioning the next generation of science on mindfulness and compassion in schools for students”. The commentary endorses the main thrust of paper, the need to re-envisage mindfulness and move from the dominant model, a clinically based “mindfulness in education” approach, in which mindfulness is seen as a discrete “intervention”, an approach which has been criticised as mechanistic, atomistic, and restrictive and encourages a view of mindfulness as helping people to cope with a stressful status quo. The commentary further endorses the view that we need to create and research models of “mindfulness as education”, as a transformative “process” models which focus on the relational and developmental aspects of education, within a whole-school, ecological approach, encouraging schools to become more compassionate places, which cultivate a positive sense of agency in learners to empower them to change the social context. As well as endorsing the main thrust of the paper, this commentary includes the following further comments. Research and practice on teacher development needs to be at the heart of this process. Getting the balance right between rigour and innovation in research will be an ongoing process. It would be helpful to look outside Anglo-centric box for examples of this relational shift. We should wait to see how the somewhat unexpected results of the MYRIAD project feed into longer term reviews before changing advice around universal approaches and who should teach mindfulness in schools.
Inter-organisational Cooperation Oriented Towards Sustainability Involving SMEs: a Systematic Literature Review
Authors: Suchek Nathalia , Franco Mário 
Published: March 2023

AbstractSmall and medium-sized enterprises (SME) are under increasing pressure to implement sustainability practices and collaborate in sustainable development. To do so, they can choose to collaborate with other organisations in order to overcome the challenges and barriers found in moving towards sustainability. Sustainability issues in SMEs have been discussed in the last two decades, but the knowledge on the inter-organisational collaboration towards sustainability remains dispersed. In this sense, this paper aims to answer the question: what is known about inter-organisational cooperation oriented towards sustainability involving SMEs? A systematic literature review (SLR) was carried out using 55 articles available on Web of Science (WoS) aiming to understand the processes of inter-organisational relations towards sustainability involving SMEs, simultaneously addressing the emergence of the circular economy. As a result, the articles were organised into four groups, namely (1) cooperation for sustainability promoted by government initiatives, (2) effects of inter-organisational cooperation for sustainability, (3) process of cooperation oriented towards sustainability, and (4) start of discussions on cooperation for the circular economy. A framework is presented with an overview of the evolution of the field, highlighting the main factors and outcomes related to inter-organisational cooperation involving SMEs for sustainability. The review provides theoretical implications as future research avenues for academics and scholars as well as practical implications for entrepreneurs, managers and policy-makers.