bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting authors' manuscript submission behaviour: A systematic review
Authors: Xu Xiaoting , Xie Juan , Sun Jianjun , Cheng Ying 
Published: February 2023

AbstractAs an important medium of science communication, academic journals promote the flow and growth of scientific knowledge. To examine the influence of factors on authors' choice of a journal, this paper reviews the literature on journal selection. A systematic review and critical interpretive synthesis methods were used in this study. A total of 132 articles were included and the content characteristics were extracted. Then, based on behavioural decision theory, the extracted data on journal selection factors were synthesized based on critical interpretive synthesis principles. Four synthetic constructs emerged: factors related to information acquisition, factors related to journal evaluation, factors related to submission outcome feedback, and factors related to the authors' backgrounds. The articles revealed that factors related to journal information acquisition and journal evaluation directly influenced authors' submission behaviour, while factors related to authors' backgrounds were moderating variables. Future research should focus on the processes of manuscript‐submission behaviour, to examine the relationships between the factors and identify the mechanisms.
Sorghum–mung bean combination snacks: Effect of extrusion temperature and moisture on chemical, functional, and nutritional characteristics
Authors: Kaur Jashandeep , Singh Baljit , Singh Arashdeep 
Published: February 2023

AbstractNine samples were formulated using whole sorghum–mung bean (70:30) at variable extrusion conditions: barrel temperature (130–170°C) and feed moisture (14–18%), and their effect on properties of snacks was examined. The results revealed that the elevation in temperature and moisture increased the antioxidant activity (ferric‐reducing antioxidant power and 2,2‐DiPhenyl‐2‐Picryl hydrazyl hydrate) and total phenolic content. This could be attributed to that the release of bound phenolics is accelerated by the extrusion treatment. However, higher temperature and lower moisture improved the functional properties such as expansion ratio, in vitro protein digestibility, overall acceptability, and expected glycemic index (50–51) of the snacks. A positive correlation was seen among slowly digestible starch and expected glycemic index of the snacks, water solubility index, and expansion ratio. A strong positive correlation was observed among total phenolic content and antioxidant activity. Higher barrel temperature (170°C) and a lower feed moisture (14%) were found to be the best combination to produce nutritious sorghum–mung bean‐based snacks. Moreover, the snacks were found to be highly likeable among the sensory panel, which proves its commercialization properties.
Light Pareto robust optimization for IMRT treatment planning
Authors: Ripsman Danielle A. , Rahimi Fahimeh , Abouee‐Mehrizi Hossein , Mahmoudzadeh Houra 
Published: February 2023

AbstractBackgroundRobust optimization (RO) has been proposed to mitigate breathing motion uncertainty during treatment in intensity‐modulated radiation therapy (IMRT) planning for breast or lung cancer. RO is a pessimistic approach that implicitly trades off average‐case for worst‐case treatment plan quality. Pareto robust optimization (PRO) provides a mechanism for improving nonworst‐case plan outcomes, but often remains overly conservative in the average case.PurposeThe goal of this study is to characterize the trade‐off between the optimality of robust IMRT plans in the worst case and the treatment quality in nonworst‐case realizations of breathing motion. We provide a light Pareto robust optimization (LPRO) method for IMRT and test its clinical viability for improving the average‐case plan quality while preserving robustness, in comparison to RO and PRO plans.MethodsFive clinical left‐sided breast cancer patients were included in the study, each with an associated 4D‐CT dataset approximating their breathing cycle. Using simulation, 50 different breathing patterns were generated for each patient. A first‐stage optimization was solved with the objective of cardiac sparing while ensuring robustness on the target dose under breathing uncertainty. Next, a second‐stage objective of overdose minimization was considered to improve plan quality in a controlled LPRO framework. For the simulated breathing scenarios, the trade‐off between loss of average cardiac sparing at worst‐case and the overdose to the breast was quantified by calculating the accumulated dose for each plan in each breathing scenario. Finally, the RO, PRO, and LPRO plans were each evaluated using eight clinical dose–volume criteria on the target and organs at risk.ResultsThe LPRO models allowed for significantly sharper dose falloffs in the expected dose instances, relative to both RO and PRO models. Plans began looking valid for delivery with average allowances of as little as +0.1 Gy additional dose to the heart, and most patients experienced diminishing returns beyond +0.2 Gy.ConclusionsWithout sacrificing robustness, the LPRO approach produces viable plans with true total‐target irradiation. Furthermore, the plans produced were able to reduce the nonworst‐case downside typical of RO, without the characteristic overdosing or average‐case pessimism seen in prior models.
Troubleshooting the pediatric gastrostomy
Authors: Blinman Thane , Hiller Dennis 
Published: February 2023

AbstractGastrostomy tubes benefit patients but also introduce hazards and costs. Most of these costs tend to be administratively invisible, but clinically expensive. Nurses, residents, emergency physicians, surgeons, and others routinely manage complaints about gastrostomy tubes or sites, and the time and effort costs are enormous. Despite widespread use of gastrostomy tubes and the large “cost of ownership,” scant instruction guides practitioners on troubleshooting the panoply of tube‐related problems. Instead, clinical folk‐wisdom leaves staff disarmed, resorting to lore or maladaptive work‐arounds that are futile or even harmful. But tubes and gastrostomies fail in predictable ways. This guide reviews commonly used gastrostomy tubes and how they are placed. Routine care of these tubes both in the immediate postoperative period and long‐term is detailed. Then, specific gastrostomy tube complications and their principle‐based countermeasures are described, organized by presenting complaint. Throughout, specific clinical pitfalls are called out along with their remedies. The aim is to demystify these devices and dispel myths that lead to error.
Mid‐infrared dual‐comb polarimetry of anisotropic samples
Authors: Hinrichs Karsten , Blevins Brianna , Furchner Andreas , Yadavalli Nataraja Sekhar , Minko Sergiy , Horvath Raphael , Mangold Markus 
Published: February 2023

AbstractThe mid‐infrared (mid‐IR) anisotropic optical response of a material probes vibrational fingerprints and absorption bands sensitive to order, structure, and direction‐dependent stimuli. Such anisotropic properties play a fundamental role in catalysis, optoelectronic, photonic, polymer and biomedical research and applications. Infrared dual‐comb polarimetry (IR‐DCP) is introduced as a powerful new spectroscopic method for the analysis of complex dielectric functions and anisotropic samples in the mid‐IR range. IR‐DCP enables novel hyperspectral and time‐resolved applications far beyond the technical possibilities of classical Fourier‐transform IR approaches. The method unravels structure–spectra relations at high spectral bandwidth up to 90 cm−1 and short integration times of 65 μs, with previously unattainable time resolutions for spectral IR polarimetric measurements for potential studies of noncyclic and irreversible processes. The polarimetric capabilities of IR‐DCP are demonstrated by investigating an anisotropic inhomogeneous freestanding nanofiber scaffold for neural tissue applications. Polarization sensitive multi‐angle dual‐comb transmission amplitude and absolute phase measurements (separately for ss‐, pp‐, ps‐, and sp‐polarized light) allow the in‐depth probing of the samples’ orientation‐dependent vibrational absorption properties. Mid‐IR anisotropies can quickly be identified by cross‐polarized IR‐DCP polarimetry.Key points
A novel dual‐comb laser‐based technique is established for polarization‐dependent mid‐infrared spectroscopy.
Independent measurements of spectral s‐ and p‐polarized transmission amplitudes and phases in the μs range.
Visualization of the anisotropy of nanofiber scaffolds as used for neural tissue applications.
Thermally conditioned aerospace‐grade carbon fiber reinforced polyether ketone ketone composites: Structure, impact response, and thermomechanical performance
Authors: Sukur Emine Feyza 
Published: February 2023

AbstractCarbon fiber‐reinforced high‐performance thermoplastic composites have recently become an efficient alternative for aerospace engineering applications. However, the temperature sensitivity of semi‐crystalline carbon fiber/polyether‐ketone‐ketone (CF/PEKK) polymers revealed the necessity of investigating their performance in service conditions. This study aims to evaluate the effect of extreme service conditions on thermomechanical performance and fracture characteristics of CF/PEKK composite laminates. For this, aerospace‐grade composite laminates were manufactured with the automated fiber placement process and were exposed to extreme service temperatures of −50°C (Conditioned I), 180°C (Conditioned II), and initially 180°C following −50°C (Conditioned III), simulating critical service temperature ranges in aerospace applications. According to impact tests, the energy absorbance of CF/PEKK composites decreased in all thermal conditioning scenarios by up to 25%. Additionally, Conditioned I samples represented relatively low glass transition temperature and degree of crystallinity compared to the control samples; however, Conditioned II and Conditioned III samples exhibited an opposite behavior. Dynamic mechanical analysis (DMA) investigations revealed a 13% reduction in the storage modulus for all thermal conditionings. While CF/PEKK composites represented ductile/brittle behavior at room temperature and high/low conditioning temperatures, their brittleness increased at −50°C, and the structure became ductile at 180°C. This study confirms that DMA is a powerful tool for determining the glass transition temperature for fiber‐reinforced composites with higher sensitivity and accuracy than DSC.
Relationship between high trait anxiety in 22q11.2 deletion syndrome and the difficulties in medical, welfare, and educational services
Authors: Nakajima Naomi , Tanaka Miho , Kanehara Akiko , Morishima Ryo , Kumakura Yousuke , Ohkouchi Noriko , Hamada Junko , Ogawa Tomoko , Tamune Hidetaka , Nakahara Mutsumi , Mori Shunsuke , Ichihashi Kayo , Jinde Seiichiro , Kano Yukiko , Sakamoto Ichiro , Tanaka Kyoko , Hirata Yoichiro , Ohashi Hirofumi , Shinohara Tokuko , Kasai Kiyoto 
Published: February 2023

AbstractAimThe 22q11.2 deletion syndrome (22q11DS) is associated with a high prevalence of mental health comorbidities. However, not enough attention has been paid to the elevated prevalence of high trait anxiety that begins early in life and may be enduring. We sought to identify specific medical, welfare, or educational difficulties associated with high trait anxiety in 22q11DS.MethodsA questionnaire‐based survey was conducted for the parents of 22q11DS individuals (N = 125). First, a multiple regression analysis was conducted to confirm the hypothesis that high trait anxiety in individuals with 22q11DS would be associated with parents' psychological distress. This was based on 19 questionnaire options regarding what difficulties the parents currently face about their child's disease, characteristics, and traits. Next, we explored what challenges faced in medical, welfare, and educational services would be associated with the trait anxiety in their child.ResultsThe multiple regression analysis confirmed that the high trait anxiety was significantly associated with parental psychological distress (β = 0.265, p = 0.018) among the 19 clinical/personal characteristics of 22q11DS. Furthermore, this characteristic was associated with various difficulties faced in the medical care, welfare, and education services, and the parent–child relationship.ConclusionTo our knowledge, this is the first study to clarify quantitatively how the characteristic of high anxiety level in 22q11DS individuals is related to the caregivers' perceived difficulties in medical, welfare, and educational services. These results suggest the necessity of designing service structures informed of the fact that high trait anxiety is an important clinical feature of the syndrome.
Genetic and epigenetic control of the plant metabolome
Authors: Hayashi Koki , Alseekh Saleh , Fernie Alisdair R. 
Published: February 2023

AbstractPlant metabolites are mainly produced through chemical reactions catalysed by enzymes encoded in the genome. Mutations in enzyme‐encoding or transcription factor‐encoding genes can alter the metabolome by changing the enzyme's catalytic activity or abundance, respectively. Insertion of transposable elements into non‐coding regions has also been reported to affect transcription and ultimately metabolite content. In addition to genetic mutations, transgenerational epigenetic variations have also been found to affect metabolic content by controlling the transcription of metabolism‐related genes. However, the majority of cases reported so far, in which epigenetic mechanisms are associated with metabolism, are non‐transgenerational, and are triggered by developmental signals or environmental stress. Although, accumulating research has provided evidence of strong genetic control of the metabolome, epigenetic control has been largely untouched. Here, we provide a review of the genetic and epigenetic control of metabolism with a focus on epigenetics. We discuss both transgenerational and non‐transgenerational epigenetic marks regulating metabolism as well as prospects of the field of metabolic control where intricate interactions between genetics and epigenetics are involved.
A bivariate CUSUM control chart based on exceedance statistics
Authors: Erem Aysegul , Mahmood Tahir 
Published: February 2023

AbstractIn manufacturing systems, statistical process control (SPC) is used to detect unusual observations in the process. Most control charts are composed based on the normality assumptions of the observations. However, checking the normality assumption in multivariate control systems cannot be practical in real‐life applications. As a result, we propose a nonparametric bivariate cumulative sum control chart (CUSUM) based on exceedance statistics for detecting the shifts in location parameters. Since the proposed chart (BCUSUM‐EX) relied on exceedance statistics and is nonparametric, the use of the chart is straightforward and practical for users. Moreover, due to the nature of CUSUM charts, the proposed chart contains information about historical and current observations. The performance of the BCUSUM‐EX chart is compared with the spatial sign CUSUM (SS‐CUSUM) control chart under some well‐known bivariate distributions such as bivariate normal, t, and gamma. The BCUSUM‐EX chart's performance is better than the SS‐CUSUM control chart regarding run length characteristics. Lastly, to show the importance of the proposed control chart, the BCUSUM‐EX chart has been applied to the aluminium electrolytic capacitor manufacturing process.
Position of Geminal Substitution of γ Amino Acid Residues Modulates Their Ability to Form Isolated Non‐Helical C12 β‐turn Mimics
Authors: Debnath Swapna , Vignesh S. R. , Satpati Priyadarshi , Chatterjee Sunanda 
Published: February 2023

AbstractWe have attempted the construction of isolated αγ non‐helical C12 β‐turn mimics in Boc‐Val‐DPro‐γx,x‐Leu‐NHMe (x,x=2/2, 3/3, 4/4) peptides by the incorporation of differentially dimethyl substituted γ amino acid residues at the (i+2) position of the turn. Solution conformation was probed in detail using NMR and CD spectroscopy. Irrespective of the solvent polarity, peptide containing γ2,2 amino acid residues failed to form the isolated tight β‐turn mimetic while peptides containing γ3,3 and γ4,4 residues successfully adopted isolated non‐helical C12 β‐turn mimic structure. The conformations adopted in solution were corroborated with DFT calculations. Such difference in the stereochemical ability of these di‐substituted γ amino acid residues arose from the difference in position of the di‐substitution along the backbone of the residue. Thus prudent choice of the position of di‐substitution in ω amino acid residues might be used as a strong peptidomimetic handle to control the structural design and generate complex structures.
Chemical Oxidation Synthesized High‐yield Carbon Dots for Acid Corrosion Inhibition of Q235 Steel
Authors: Zhu Jiajia , Zhu Mengyue , He Zhongyi , Xiong Liping , Zhang Renhui , Guo Lei 
Published: February 2023

AbstractIn this work, high‐yield carbon quantum dots (CQDs) are successfully synthesized by a simple chemical oxidation method using acetaldehyde as raw material. Fourier‐transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), thermogravimetry (TGA), and XPS are used to analyze the structural characteristics of CQDs. The results demonstrate that many oxygen‐containing functional groups are on the surface of carbon nuclei. The inhibitive efficiency of electrochemical experiments and weight loss is 87.1 % and 95.3 %, respectively. SEM observes the surface morphology of the sample after 72 h corrosion with or without CQDs, and EDS analysis confirms that CQDs are effectively adsorbed on the surface of carbon steel. Furthermore, through calculation, the standard adsorption‐free energy of CQDs is −25 kJ/mol, concluding that the adsorption process is a combination of physisorption and chemisorption. This work is helping to solve the corrosion problem of metal equipment in the acid process.
Nanozyme‐Based Colorimetric SARS‐CoV‐2 Nucleic Acid Detection by Naked Eye
Authors: He Mengya , Xu Xican , Wang Hongyu , Wu Qingyuan , Zhang Linghao , Zhou Dongsheng , Tong Yigang , Su Xin , Liu Huiyu 
Published: February 2023

AbstractFluorescence‐based PCR and other amplification methods have been used for SARS‐CoV‐2 diagnostics, however, it requires costly fluorescence detectors and probes limiting deploying large‐scale screening. Here, a cut‐price colorimetric method for SARS‐CoV‐2 RNA detection by iron manganese silicate nanozyme (IMSN) is established. IMSN catalyzes the oxidation of chromogenic substrates by its peroxidase (POD)‐like activity, which is effectively inhibited by pyrophosphate ions (PPi). Due to the large number of PPi generated by amplification processes, SARS‐CoV‐2 RNA can be detected by a colorimetric readout visible to the naked eye, with the detection limit of 240 copies mL−1. This conceptually new method has been successfully applied to correctly distinguish positive and negative oropharyngeal swab samples of COVID‐19. Colorimetric assay provides a low‐cost and instrumental‐free solution for nucleic acid detection, which holds great potential for facilitating virus surveillance.
Metal protoporphyrin‐induced self‐assembly nanoprobe enabling precise tracking and antioxidant protection of stem cells for ischemic stroke therapy
Authors: Shu Yimeng , Shen Hui , Yao Minghua , Shen Jie , Yang Guo‐Yuan , Chen Hangrong , Tang Yaohui , Ma Ming 
Published: February 2023

AbstractMesenchymal stem cell (MSC)‐based therapy has provided a promising strategy for the treatment of ischemic stroke, which is still restricted by the lack of long‐term cell tracking strategy as well as the poor survival rate of stem cells in ischemic region. Herein, a dual‐functional nanoprobe, cobalt protoporphyrin‐induced nano‐self‐assembly (CPSP), has been developed through a cobalt protoporphyrin IX (CoPP) aggregation‐induced self‐assembly strategy, which combines CoPP and superparamagnetic iron oxide (SPION) via a simple solvent evaporation‐driven method. Without any additional carrier materials, the obtained CPSP is featured with good biocompatibility and high proportions of active ingredients. The SPIONs in CPSPs form a cluster‐like structure, endowing this nano‐self‐assembly with excellent T2‐weighted magnetic resonance (MR) imaging performance. Furthermore, the CoPP released from CPSPs could effectively protect MSCs by upregulating heme oxygenase 1 (HO‐1) expression. The in vivo cell tracing capacity of CPSPs is confirmed by monitoring the migration of labeled MSCs with MR imaging in a middle cerebral artery occlusion mouse model. More importantly, the sustained release of CoPP from CPSPs improves the survival of transplanted MSCs and promotes neural repair and neurobehavioral recovery of ischemic mice. Overall, this work presents a novel dual‐functional nanoagent with an ingenious design for advancing MSC‐based therapy.
Mechanical properties, durability performance and interlayer adhesion of 3DPC mixtures: A state‐of‐the‐art review
Authors: Şahin Hatice Gizem , Mardani Ali 
Published: February 2023

AbstractIn this study, the strength and durability performance of 3D printing concrete mixtures (3DPC) were examined in terms of the materials used in their production and printing process parameters (interlayer interval time, printing speed, and nozzle shape). Due to the anisotropic nature of 3DPC, it was understood that the compressive strength depends on the loading direction. It was emphasized that it is necessary to control the shrinkage behavior of 3DPC mixtures due to the lack of formwork and the high dosage of binders. It was reported that the interlayer adhesion of 3DPC is highly dependent on the interlayer interval time and printing speed parameters. It was understood that nozzle shape and standoff distance affect the mechanical properties and surface roughness of 3DPC specimens, and this effect is more pronounced in mixtures with high static yield stress values.
Shear performance of stirrup corroded RC beams: Effects of strengthening interventions and corrosion rates
Authors: Ke Lu , Liang Longming , Zhou Jiale , Li Cong , Li Youlin , Chen Can 
Published: February 2023

AbstractThis paper investigates the shear performance of corroded reinforced concrete (RC) beams with different stirrup corrosion rates and strengthening interventions. In this work, eight corroded beams strengthened with various interventions, including U‐shaped stirrup, bonded steel plate, and anchored steel plate strengthening techniques, were tested under static loading. The experimental shear capacity, load–deflection response, and failure modes of the unstrengthened and strengthened specimens were carefully studied. Three shear capacity models based on GB50010‐2010, ACI 318‐08, and Eurocode 2 codes were proposed and discussed. The results showed that all specimens have the same failure mode, that is, the shear–compression failure. The shear capacities are improved by 17.36%–23.61% and 23.76%–38.46% by these interventions for the specimens with 10% and 20% stirrup corrosion rates, respectively. The anchored steel plate technique provides the maximum improvement in the shear capacity. Additionally, the increased stiffness of corroded specimens with strengthening interventions is apparent when the corrosion rate is 10% but not obvious when the corrosion rate is 20%. The models based on GB50010‐2010 and ACI 318‐08 codes were proved to have higher accuracy but may overestimate the shear capacity. In contrast, the Eurocode 2‐based model comes with relatively low prediction accuracy but conservative results, and it is recommended for engineering design.