bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seven Stage Model of the Soft System Methodology for Software Development Process
Authors: Günaydın Gökçe , Yıldırım Sevgi Özkan 
Published: July 2023

Abstract
Organizations always try to improve processes, optimize workflows and minimize turnover rate in order to enhance efficiency, increase productivity, reduce waste and improve performance. Process improvement is a vital component for organizations and it can be achieved through a variety of quality methods, such as, total quality management, Lean, Six Sigma and etc. Process improvement begins with complete understanding of current processes which requires data analysis, stakeholder engagement followed by an implementation with proper methods. Soft Systems Methodology (SSM) is a perfect problem-solving approach to analyze complex processes and to find suitable implementations. This paper uses SSM in software development process (SDP) within two interrelated organizations. In this research, SSM applies some problem-solving techniques, such as systems thinking, rich picture drawings, root definition and related systems construction, conceptual model creations and action planning to maintain continuous process improvement. This thesis study contains four sub-processes of SDP. These sub-processes are called Design Management, Technical Development, Testing and Training processes. Seven-staged SSM is applied to sub-processes in order to enhance system performance. Last stage of SSM, which is action taking, is presented however it is not applied yet. Apart from this, rich pictures of sub-processes are drawn, relevant systems and root definition are identified, conceptual models are created with focus group studies. Lastly, suggestions are offered regarding to real world activities and conceptual models. Results of study shows effectiveness of SSM for ill-structured problems in SDP. It emphasizes real world activities and proposes needed activities in sub-processes to overcome issues in SDP.
A Parallel Hybrid Model for Integrating Protein Adsorption Models with Deep Neural Networks
Authors: Gama Marlon de Souza Gama , Lima Fernando Arrais Romero Dias Lima , Santana Vinícius Viena Santana , Nogueira Idelfonso Bessa dos Reis Nogueira , Tavares Frederico Wanderley Tavares , Barreto Amaro Gomes Barreto Junior 
Published: July 2023

Abstract
A high-accuracy modeling of the mass front evolution in a fixed bed is determined by considering the equilibrium information of the components’ concentration adsorbed on the stationary phase. Thus, adsorption isotherms based on thermodynamic principles are required in the mass balance. It is challenging to include isotherms with a high level of detail due to the necessity to compile it on each instant and position, drastically increasing the computation time. Pattern identification methods may be a solution to use a high-level isotherms model quickly and efficiently. Here, we structure a Deep Neural Network aiming to train a surrogate model using the solution of a non-linear Poisson-Boltzmann equation as a data set, modified to include the ionic dispersion potential from the Lifshitz Theory. Thus, the surrogate model output is used in the mass balance model while solving the partial differential equations which describe a column mass front. This approach generates a hybrid model in a serial identification strategy. For a case study, we analyze the mass front behavior of lysozyme in a silica-packed-bed column from pH 6 to pH 10, using different salts: NaCl, NaBr, and NaI. The results indicate a low retention time for the pHs near the isoelectric points for lysozyme (pH 10.8) and silica (pH 5.7) [1]. In addition, differences in salt types allow a significant decay in retention time and an increase in mass front compressibility in the following order: I– > Br– > Cl– due to the differences in anion polarizability. The results here indicate that a link between different scales is successfully achieved using DNN.
Transcriptomic Profiling Identified Hub Genes Linking Barrett’s Esophagus and Esophageal Adenocarcinoma
Authors: Zhang Yuting , Dai Jiacheng , Wang Danke , Zhou Jiaqi , Wang Shangzi , Suo Chen , Chen Xingdong 
Published: July 2023

Abstract
Background Barrett’s esophagus (BE) is a common type of metaplasia and is recognized as a precursor of esophageal adenocarcinoma (EAC). However, the gene expression pattern underlying the progression of BE and EAC remains to be comprehensively explained. Herein we performed transcriptomic analyses using public microarray data (158 EAC, 51 BE, and 27 control samples).Results Differentially expressed genes that were common and unique to BE and EAC were consequently identified. Further, NFE2L3 and MCM2 showed a higher effect size in EAC than in BE; we validated their biological functions in influencing cell proliferation using CRISPR screen data. We found that the common DEGs between EAC and BE were strongly enriched for development, differentiation, and proliferation in keratinocytes. Besides, our co-expression network revealed shared and distinct gene regulation patterns in EAC and BE. Cell markers of fibroblasts were enriched in EAC/BE-shared modules, suggesting the tissue microenvironment in BE undergoes similar dysregulation as in EAC. T cells were found to be enriched in EAC-specific modules, highlighting the involvement of the immune response against tumors. Moreover, we used an independent dataset from The Cancer Genome Atlas to validate hub genes in EAC-specific modules.Conclusions To summarize, our findings provide comprehensive insights into the gene expression profile of BE and EAC and highlight the potential roles of key regulator genes and hub genes, some of which may have a potential clinical application.
A predictive model for early death in elderly colorectal cancer patients: A population-based study
Authors: Wang QI , Shen Kexin , Fei Bingyuan , Luo Hai , Li Ruiqi , Wang Zeming , Wei Mengqiang , Xie Zhongshi 
Published: July 2023

Abstract
Purpose The purpose of the present study was to investigate independent risk factors for early death in elderly colorectal cancer patients (ECRC) and to develop prediction model.Methods Patients diagnosed with ECRC in Surveillance, Epidemiology, and End Result datasets (SEER) between 2010 and 2015 were included in this retrospective cohort study. For external validation, a data set from the Chinese population was gathered. Logistic regression analyses were used to identify independent risk factors for early death and to establish nomograms. Internal and external validation was performed to evaluate the nomograms using the receiver operating characteristic curve (ROC), calibration curve, and decision curve analysis (DCA).Results A total of 28111 patients in the SEER cohort and 222 patients in the Chinese cohort were included. Patients from the SEER database were randomly divided into the training cohort (n = 19,679) and internal validation cohort (n = 8,432). Patients in the Chinese cohort were selected for the external validation cohort. Overall, 3579(12.73%) patients experienced early death in the SEER cohort and 31(13.96%) in the Chinese cohort. Two reliable nomograms were constructed on the basis of some significant risk factors. Internal validation and external validation of the nomograms showed high accuracy in predicting early death.Conclusion These nomograms were considered practical tool to predict the risk of early death in ECRC patients. It was no doubt that it would aid in clinical decision-making and the development of tailored treatment strategies for this group.
Building and Evaluating Prospective Scenarios for Corn-based Biorefineries
Authors: Matos Jullyana Souza , Justi Ana Clara Alves , Miranda Júlio Cesar de Carvalho 
Published: July 2023

Abstract
Global warming and increasing environmental pollution have become global concerns that, coupled with the scarcity of traditional forms of energy, have motivated the implementation of more sustainable production systems, such as biorefineries. This is because biorefineries are capable of integrating technologies and processes in a single facility, generating biofuels, value-added chemicals, and energy. Thus, the aim of the study was to investigate the bioproducts and emergent technologies surrounding the processing of corn into bioethanol and refined oil. A bibliometric analysis he was carried out in order to construct and evaluate prospective scenarios related to corn biorefineries. An analysis of the proposed layouts highlighted flexibility in the production process, given that one raw material could be transformed into various bioproducts. Thus, the results presented provide a bibliographic foundation for future studies on integrating residues-processes-products in corn processing. The reason for this is that the technological routes presented could be considered incremental innovations to develop a biorefinery, which takes place gradually, given that highly integrated biorefineries are highly complex.
The Challenge of Transdisciplinarity: the Subject Area "Conflict-Compromise"
Authors: Шабунина А.К. 
Published: July 2023

В статье рассматриваются аспекты конструирования и реализации исследовательских трансдисциплинарных моделей применительно к проблемному полю «конфликт-компромисс». Описываемые теоретические конструкты становятся ответом на запрос о многомерном изучении отдельного явления прошлого. Автор приводит анализ этапов развития конфликта и его эволюцию в компромисс через наддисциплинарную категорию культуры. Делается вывод, что трансдисциплинарные модели как проявление метанаучной методологии строятся на основе выбора, апробирования и иерархизации традиционного инструментального набора методов с учетом феноменологической специфики объекта исследования.
The article discusses aspects of the construction and implementation and research of transdisciplinary models in relation to the problem field "conflict-compromise". The described theoretical constructions have become a response to a request for a multidimensional study of individual phenomena of the past. The author provides an analysis of the analysis of the development of the conflict and its evolution in compromise through the supra-disciplinary structure of culture. It is concluded that transdisciplinary models as a demonstration of metascientific methodology are built on the basis of the selection, testing and hierarchization of a reliable instrumental set of methods, taking into account the phenomenological specifics of the object of study.
Sussex School of Intellectual History
Authors: Горбунов А.В. 
Published: July 2023

Сассекская школа – это одно из направлений современной интеллектуальной истории. Актуальность статьи обусловлена тем, что интеллектуальная история в России является востребованным методом, о чём свидетельствуют всё чаще появляющиеся статьи с ключевым словосочетанием «интеллектуальная история». В данной статье представлен аналитический обзор основных принципов данной школы и отношения к ней со стороны других исследовательских направлений. В рамках критического анализа установлен характер самоидентификации её представителей, рассмотрена история становления школы, сформулированы основные идеи и принципы методологии Школы. Показано, что в основании её подхода положен поликонтекстуальный взгляд на интеллектуальную жизнь прошлого; указывается, что историками Сассекской школы предлагается особый исследовательский подход с крайне историкоориентированным, эклектичным и междисциплинарным характером.
The article is devoted to the Sussex School that is one of the directions of modern intellectual history. The relevance of the article is due to the fact that intellectual history in Russia is a popular method, as evidenced by the increasingly appearing articles with the keyword "intellectual history". This article presents an analytical review of the basic principles of this school and the attitude towards it from other research areas. Within the framework of the critical analysis, the nature of the self-identification of its representatives is established; the history of the formation of the school is considered; the main ideas and principles of the methodology of the School are formulated. It is shown that its approach is based on a polycontextual view of the intellectual life of the past; it is pointed out that the historians of the Sussex School offer a special research approach with an extremely historically oriented, eclectic and interdisciplinary character.
Eventfulness and Mundanity in Personal Diarys: Narrative vs Mentative
Authors: Савушкин И.С. 
Published: July 2023

Статья посвящена сравнительному анализу личных дневников белоэмигрантов начало 20-х годов, прошлого века, пересекающих границу России или уже находящихся за ее пределами. В качестве аналитического инструмента автор использует понятие «ментатив», которое было введено Н.В. Максимовой в ее докторской монографии. По словам Максимовой, ментатив означает мысль-рассуждение в его речевой форме. Автором статьи устанавливается следующая корреляция: дневниковая наррация прямо связана с перемещением автора в пространстве и внешней событийностью, тогда как стратегия ментатива эксплицирует отсутствие внешних событий, остановку динамики, и фиксацию ментального состояния автора. При этом, установлено, что переход нарратива к ментативу и обратно оказывается связанным с пересечением границ государств.
This article is concerned with a comparative analysis of the personal diaries of White Russian émigrés of the early 1920s who crossed the border of Russia or were already outside of it. As an analytical tool, the author uses the concept of "mentative", which N.V. Maximova introduced in her doctoral dissertation. According to Maximova, mentative means speculative thinking in a verbal form. The author of this article establishes the following correlation: diary narration is directly related to the diarist migration and current location together with external events and circumstances, whilst the strategy of mentative explicates the absence of such external events, lack of dynamics, and fixed mental state of the diarist. At the same time, it has been established that transitioning from the narrative to the mentative and vice versa is associated with crossing state borders.
New colors for the portrait of Militsa Vasilyevna Nechkina
Authors: Корзун В.П. , Сидорова Л.А. 
Published: July 2023

Рассматривается эвристический потенциал новой документальной публикации творческого наследия академика М.В. Нечкиной, составленной В.Г. Бухертом. Показано, как ее переписка с историками, писателями и деятелями культуры, а также поэтическое творчество могут открывать неизвестные ранее стороны яркой и разносторонней личности выдающегося ученого и многие страницы советской исторической науки в целом.
The heuristic potential of a new documentary publication of the creative heritage of academician M.V. Nechkina, compiled by V.G. Bukhert, is considered. It is shown how her correspondence with historians, writers and cultural figures, as well as poetic creativity can reveal previously unknown sides of the bright and versatile personality of an outstanding scientist and many pages of Soviet historical science as a whole.
When They Turn Feathers to Bayonets (Review of Maciej Górny's “The Great War of the Professors”)
Authors: Пискунов М.О. 
Published: July 2023

Статья является рецензией на книгу польского историка Мацея Гурного «Великая война профессоров», посвященную идеологическим столкновениям интеллектуалов враждующих сторон Первой мировой войны. Концентрируясь на восточно-европей-ских географах, физических антропологах, психологах и врачах, автор рисует широкое полотно взаимных упреков и обвинений, в которые превратилась наука враждующих стран после 1914 г. Гурный демонстрирует, как эти в научном смысле бесплодные рассуждения стали основой политической операционализации понятия раса. Истоком такого нового для Европы военного режима социально-гуманитарных наук автор видит полемику французских и немецких интеллектуалов периода 1870–1871 гг.
This article is a review of a book by Polish historian Maciej Górny, "The Great War of Professors," which deals with the ideological clashes between intellectuals on opposing sides of the First World War. Concentrating on Eastern European geographers, physical anthropologists, psychologists, and physicians, the author draws a broad canvas of mutual recriminations and accusations into which the science of the warring countries turned after 1914. Gurny demonstrates how this scientifically sterile discourse became the basis for the political operationalization of the concept of race. The author sees the origins of this new European military regime of the social and human sciences in the polemics of French and German intellectuals of the period 1870-71.
Evaluation of coronal microleakage in teeth with intraorifice barriers at 2mm and 3mm: An in vitro study
Authors: Rawat Dr Ananya , Gurtu Dr Anuraag 
Published: July 2023

Context:
An intraorifice barrier after endodontic therapy could remarkably mitigate the movement of bacteria and their by-products and improve the long-term prognosis of a root canal treated teeth by serving as barriers against fluid and bacterial ingress.
Aims:
The idea of the present study was to compare the coronal microleakage in teeth with 2-mm and 3mm intraorifice barriers of Bulkfill flowable composite, Glass Ionomer Cement (GIC), Cention and Biodentin under a stereomicroscope.
Methods and Material:
Eighty freshly extracted human single rooted mandibular premolars with single canal were chosen for the study. Teeth were obturated with gutta-percha using AH plus sealer. The teeth were further divided into 5 groups (16 premolars each) on the basis of intraorifice barrier material used: Bulkfill composite, GIC, Cention, Biodentin and control group. These groups were further subdivided into 2 subgroups each of 2mm and 3mm (8 teeth each) and evaluated under stereomicroscope
Statistical analysis used:
Coronal microleakage was determined under stereomicroscope using 15X magnification. Data were statistically analyzed using two-way ANOVA
Results:
According to the results, GlC at 2mm exhibited the highest micro leakage and least microleakage was shown by Biodentin at 3mm.
Conclusions:
Intraorifice barriers play a key role in reducing coronal microleakage.
Keywords:
Biodentine, Bulkfill composite, Cention, Coronal microleakage, Glass Ionomer Cement, intraorifice barrier
A unique method to study different histological structures using Hematoxylin and Eosin staining in partially decalcified ground sections of teeth : A research article
Authors: HIMANSHU SINGH  , VEDANT PATEL  
Published: July 2023

Introduction: Examining the tooth is considered as foremost segment in research in the field of oral biology and oral pathology. For studying various structures like enamel, dentin and cementum, ground section of teeth is used, while decalcified sections of tooth are used for studying the soft tissues.
Objective: The present study was aimed at exploring the normal structures of hard tissue parts of the teeth where partially decalcified ground sections were stained them with routine hematoxylin and eosin stain.
Methodology: For the present study, a total of 30 extracted teeth were collected. The freshly prepared ground sections were partly decalcified by putting ground sections of teeth in 10% nitric acid for a time period of 20- 25 seconds. After this, the ground sections of teeth are washed in tap water. The partly decalcified ground sections of teeth were stained with routine hematoxylin and eosin staining procedure and were mounted on clean glass slides using DPX mounting media. The sections were then analyzed for various histological structures under the microscope.
Results: When hematoxylin and eosin stained partially decalcified ground sections of teeth were viewed under light microscope, variety of histological structures appeared as stained, while some structures did not take stain and remain unstained.
Conclusion: After preparing and staining the ground section of teeth by our method, we hope that it would be of great help for undergraduate students and to some extent the research scholars to understand the various structures of the teeth in a better and easy way.
Local Drug Delivery of Aloe Vera Gel in Chronic Periodontitis Patient.
Authors: Dr Sharmistha Vijay  , Dr Rekha Meena  , Dr Debopriya Chatterjee  , Dr Rajeev Soangra  , Dr Akansha Goyal  , Dr Vasundhara Prakash  
Published: July 2023

BACKGROUND- Since historical times, for both medical and dental therapy many herbal agents, like Aloe vera (AV), have been used. Aloe vera (AV) belonging to the Liliaceae Family, presents with anti-inflammatory, antioxidant, antibacterial, antiviral, antifungal and immune boosting properties. It also promotes wound healing by accelerating epithelial cell migration and collagen maturation, facilitating tissue restoration. This study aims at investigating the clinical effectiveness of locally delivered AV gel used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP).MATERIAL AND METHODS: Sixty patients with probing depth (PD) ≥5mm and clinical attachment (CA) level ≥3mm were randomly divided into two groups. All patients underwent SRP. Aloe Vera gel was locally delivered in Group 1 patients and Placebo in Group 2 patients. Clinical recording of full mouth plaque index (PI), bleeding index (BI), probing depth (PD) and clinical attachment (CA) level was done first at baseline and then at intervals of 3 months and 6 months.RESULT: Patients in AV group showed significantly greater mean reductions in PI, BI and PD and mean gain in CA level compared to those in placebo group from baseline to 3 months. Gain in CA level was significantly greater in AV group at all time intervals than the placebo group.CONCLUSION: Adjunctive use of AV gel LDD, in comparison to placebo gel LDD, is associated with greater reduction in PI, BI and PD as well as more gain in CA level in patients with CP.
Charecterization of A Complete Denture :- A Case Report
Authors: Mundra Rohit , Jajodia Madhur , Porwal Surbhi 
Published: July 2023

Characterization is a process in which the character or collective qualities of a person are introduced in complete denture either by modification of teeth or by modification of denture bases ,to make it more natural for that person , characterization of complete denture is necessary to give the denture a leaf like appearance , to make it appear more natural this case report reviews various principles in an effort to produce a natural appearing denture.
Therapeutic Effects of Diode Laser on the Treatment of Epulis : A Case Report
Authors: Ray Shanvi , Joshi Chander Shekhar , Shukla Pradeep , Shiwach Rashmi 
Published: July 2023

Abstract
INTRODUCTION :- Epulis is a pseudo-tumor growth characterized by fibrous connective tissue hyperplasia in gingivobuccal region. The swelling is usually a result of a local irritant such as calculus formation or a poorly adapted margin of a dental restoration.
AIM : - The aim of this case report is removal of an epulis using diode laser, which was located at the aesthetic zone of the lower incisors, and to report on associated changes in the periodontal parameters such gingival inflammation and the position of the tooth following the introduction of an effective oral hygiene regime for the patient.
OBJECTIVE :- To evaluate the outcome of surgically excised Epulis using diode laser located at the aesthetic zone of the lower incisors in a 27 years old female patient.
METHODOLOGY :- Surgical excision of Epulis by diode laser (810 nm) under local anesthesia.
RESULT :- Complete re-epithelization and healing was seen at 1 and 4 weeks time interval.
CONCLUSION :- Epulis is observed in patients with poor oral hygiene in areas with local irritating factors. Tissue excision should not extend beyond to the periosteum and adjacent teeth should be thoroughly scaled to remove any source of irritation. Coagulation properties associated with the use of diode laser are beneficial during removal of tumors of inflammatory origin with bleeding tendencies. There is less post-operative bleeding, pain and swelling.
Keywords: Diode laser, Oral lesions, Epulis granulomatosa, Female