bluuebunny/crossref_metadata_2025_split huggingface dataset:
The biting rate of Aedes aegypti and its variability: A systematic review (1970–2022)
Authors: Zahid Mondal Hasan , Van Wyk Hannah , Morrison Amy C. , Coloma Josefina , Lee Gwenyth O. , Cevallos Varsovia , Ponce Patricio , Eisenberg Joseph N. S. 
Published: August 2023

Background
Transmission models have a long history in the study of mosquito-borne disease dynamics. The mosquito biting rate (MBR) is an important parameter in these models, however, estimating its value empirically is complex. Modeling studies obtain biting rate values from various types of studies, each of them having its strengths and limitations. Thus, understanding these study designs and the factors that contribute to MBR estimates and their variability is an important step towards standardizing these estimates. We do this for an important arbovirus vector Aedes aegypti.

Methodology/Principal findings
We perform a systematic review using search terms such as ‘biting rate’ and ‘biting frequency’ combined with ‘Aedes aegypti’ (‘Ae. aegypti’ or ‘A. aegypti’). We screened 3,201 articles from PubMed and ProQuest databases, of which 21 met our inclusion criteria. Two broader types of studies are identified: human landing catch (HLC) studies and multiple feeding studies. We analyze the biting rate data provided as well as the methodologies used in these studies to characterize the variability of these estimates across temporal, spatial, and environmental factors and to identify the strengths and limitations of existing methodologies. Based on these analyses, we present two approaches to estimate population mean per mosquito biting rate: one that combines studies estimating the number of bites taken per gonotrophic cycle and the gonotrophic cycle duration, and a second that uses data from histological studies. Based on one histological study dataset, we estimate biting rates of Ae. aegypti (0.41 and 0.35 bite/mosquito-day in Thailand and Puerto Rico, respectively).

Conclusions/Significance
Our review reinforces the importance of engaging with vector biology when using mosquito biting rate data in transmission modeling studies. For Ae. aegypti, this includes understanding the variation of the gonotrophic cycle duration and the number of bites per gonotrophic cycle, as well as recognizing the potential for spatial and temporal variability. To address these variabilities, we advocate for site-specific data and the development of a standardized approach to estimate the biting rate.
The added value of haemoglobin to height, age, and sex to predict DLCO in subjects with preserved exercise capacity
Authors: Priel Eldar , Diab Nermin , Patel Matthew , Wahab Mustafaa , Freitag Andreas , O’Byrne Paul M. , Killian Kieran J. , Satia Imran 
Published: August 2023

Background
The single breath diffusion capacity for carbon monoxide (DLCO) captures several aspects of the role of the lung in meeting the metabolic demands of the body. The magnitude of the independent contributors to the DLCO is unknown. The aim of this study was to investigate the factors that independently contribute to the DLCO.

Objectives
The objective was to investigate the impact of height, age, sex and haemoglobin on DLCO, alveolar volume (VA) and carbon monoxide transfer coefficient (KCO).

Methods
Study participants were pre-screened based on normal exercise capacity achieved during an incremental cardio-pulmonary exercise testing (CPET) using cycle ergometry at McMaster University Medical Center between 1988–2012. Participants who had an FEV1>80% predicted, with an FEV1/FVC ≥0.7 and who achieved a maximum power output ≥80% were selected for analysis. In total, 16,298 subjects [61% male, mean height 1.70m (range 1.26–2.07), age 49 yrs (10–94), weight 79 kg (23–190) had DLCO measured while demonstrating normal spirometry and exercise capacity.

Results
The DLCO increased exponentially with height, was 15% greater in males, increased with age yearly until 20, then decreased yearly after the age of 35, and was 6% higher per gram of haemoglobin (5.58*Height(m)1.69*1.15 in Males*(1–0.006*Age>35)*(1+0.01*Age<20) *(1+0.06*Hb gm/dl), (r = 0.76).

Conclusion
Height, age, sex, and haemoglobin all have independent influence on the DLCO in subjects with normal spirometry and preserved exercise capacity.
Compostos de Morinda citrifolia como indutores de respostas bioquímicas em plantas de melão.
Authors: Dias Bruna Letícias , Dalcin Mateus Sunti , Costa Priscila Fonseca da , Santos Patrícia Resplandes Rocha dos , Sousa Rosangela Ribeiro de , Dias Felipe Rocha , Mourão Dalmarcia de Souza Carlos , Santos Gil Rodrigues dos 
Published: August 2023

As plantas apresentam mecanismos complexos de defesa estrutural e bioquímica que podem ser ativados antes ou após o ataque de microrganismos fitopatogênicos. Dentre esses mecanismos, estão as proteínas relacionadas à patogênese (PRP) e a resposta hipersensível através da produção de espécies reativas de oxigênio (ERO), as quais auxiliam na defesa contra os fitopatógenos e redução da toxicidade dos radicais livres. A ativação deste sistema pode ser por fatores bióticos ou abióticos que podem estimular a atividade bioquímica, denominadas substâncias elicitoras, como óleos essenciais e seus constituintes. Estudos na área são necessários para aprofundar conhecimento e atingir a viabilidade técnica e econômica de seu uso em benefício da agricultura sustentável. Objetivou-se avaliar a atividade enzimática de plantas de meloeiro submetidas à aplicação de óleo essencial de noni (OE) e ácido octanóico (AO). Foram testadas diferentes concentrações dos tratamentos e como testemunhas: fungicida Cerconil® (0,2%) e estimulante vegetal Yantra®. As enzimas com atividade avaliada foram superóxido dismutase (SOD), quitinase (QUIT), ascorbato peroxidase (APX) e catalase (CAT). O ácido octanóico (0,1%) e óleo essencial (0,5%) foram os maiores ativadores da SOD dentre os tratamentos testados. A APX teve sua produção aumentada pela aplicação de ácido octanóico à 0,1%. O OE foi o maior ativador da CAT na concentração de 2%. Confirmando a atividade dos metabólitos secundários de Morinda citrifolia como ativadores do sistema de defesa e provável ação imediata contra microrganismos. Considerando assim compostos potenciais para o desenvolvimento de um bioproduto como substituto de defensivos agrícolas.

Palavras-chave: bioprodutos, compostos naturais, Cucumis melo L., espécies reativas de oxigênio, óleo essencial.
Effects of photobiomodulation and caffeine treatment on acute kidney injury in a hypoxic ischemic neonatal rat model
Authors: Groves A. M. , Johnston C. J. , Beutner G. , Dahlstrom J. E. , Koina M. , O'Reilly M. , Marples B. , Porter G. , Brophy P. D. , Kent A. L. 
Published: August 2023

AbstractHypoxic ischemic encephalopathy (HIE) occurs in 2–5/1000 births, with acute kidney injury (AKI) occurring in 40%. AKI increases morbidity and mortality. Caffeine, an adenosine receptor antagonist, and photobiomodulation (PBM), working on cytochrome c oxidase, are potential treatments for AKI. To examine effects of caffeine and PBM on AKI in rats, Day 7 pups underwent a HIE intervention (Modified Rice–Vannucci model) replicating pathology observed in humans. Caffeine was administered for 3 days and/or PBM for 5 days following HIE. Weights and urine for biomarkers (NGAL, albumin, KIM‐1, osteopontin) were collected prior to HIE, daily post intervention and at sacrifice. Both treatments reduced kidney injury seen on electron microscopy, but not when combined. HIE elevated urinary NGAL and albumin on Days 1–3 post‐HIE, before returning to control levels. This elevation was significantly reduced by PBM or caffeine. KIM‐1 was significantly elevated for 7 days post‐HIE and was reduced by both treatments. Osteopontin was not altered by HIE or the treatments. Treatments, individually but not in combination, improved HIE‐induced reductions in the enzymatic activity of mitochondrial complexes II‐III. PBM and caffeine also improved weight gain. PBM and caffeine reduces AKI diagnosed by urinary biomarkers and confirmed by EM findings.
Cold water immersion in recovery following a single bout resistance exercise suppresses mechanisms of miRNA nuclear export and maturation
Authors: D'Souza Randall F. , Figueiredo Vandre C. , Markworth James F. , Zeng Nina , Hedges Christopher P. , Roberts Llion A. , Raastad Truls , Coombes Jeff S. , Peake Jonathan M. , Mitchell Cameron J. , Cameron‐Smith David 
Published: August 2023

AbstractCold water immersion (CWI) following intense exercise is a common athletic recovery practice. However, CWI impacts muscle adaptations to exercise training, with attenuated muscle hypertrophy and increased angiogenesis. Tissue temperature modulates the abundance of specific miRNA species and thus CWI may affect muscle adaptations via modulating miRNA expression following a bout of exercise. The current study focused on the regulatory mechanisms involved in cleavage and nuclear export of mature miRNA, including DROSHA, EXPORTIN‐5, and DICER. Muscle biopsies were obtained from the vastus lateralis of young males (n = 9) at rest and at 2, 4, and 48 h of recovery from an acute bout of resistance exercise, followed by either 10 min of active recovery (ACT) at ambient temperature or CWI at 10°C. The abundance of key miRNA species in the regulation of intracellular anabolic signaling (miR‐1 and miR‐133a) and angiogenesis (miR‐15a and miR‐126) were measured, along with several gene targets implicated in satellite cell dynamics (NCAM and PAX7) and angiogenesis (VEGF and SPRED‐1). When compared to ACT, CWI suppressed mRNA expression of DROSHA (24 h p = 0.025 and 48 h p = 0.017), EXPORTIN‐5 (24 h p = 0.008), and DICER (24 h p = 0.0034). Of the analyzed miRNA species, miR‐133a (24 h p < 0.001 and 48 h p = 0.007) and miR‐126 (24 h p < 0.001 and 48 h p < 0.001) remained elevated at 24 h post‐exercise in the CWI trial only. Potential gene targets of these miRNA, however, did not differ between trials. CWI may therefore impact miRNA abundance in skeletal muscle, although the precise physiological relevance needs further investigation.
AlgDiff: an open source toolbox for the design, analysis and discretisation of algebraic differentiators
Authors: Othmane Amine , Rudolph Joachim 
Published: August 2023

AbstractAlgebraic differentiators have attracted much interest in recent years. Their simple implementation as classical finite impulse response digital filters and systematic tuning guidelines may help to solve challenging problems, including, but not limited to, nonlinear feedback control, model-free control, and fault diagnosis. This contribution introduces the open source toolbox AlgDiff for the design, analysis and discretisation of algebraic differentiators.
Einbettungsbeobachter für polynomiale Systeme
Authors: Gerbet Daniel , Röbenack Klaus 
Published: August 2023

ZusammenfassungIn vielen Anwendungen der Regelungstechnik werden Beobachter eingesetzt, um interne Zustandsgrößen oder Parameter zu schätzen oder Fehler zu detektieren. Solche Beobachter lassen sich auch für nichtlineare Systeme systematisch auf Basis der Beobachter- oder der Beobachtbarkeitsnormalform entwerfen. Letztere existiert für eine größere Systemklasse. Allerdings ist das Vektorfeld in der Beobachtbarkeitsnormalform nicht unbedingt an allen Punkten definiert oder Lipschitz-stetig, selbst wenn diese Eigenschaften auf die ursprüngliche Systemdarstellung zutreffen. Durch die Einbettung in höherdimensionale Räume ist es möglich, die Normalform einerseits zu konstruieren und gegebenenfalls gewisse singuläre Punkte zu vermeiden. In diesem Beitrag wird gezeigt, wie dies systematisch für polynomiale Systeme mit mehreren Ein- oder Ausgängen bewerkstelligt werden kann.
Passive nonreciprocal transmission and optical bistability based on polarization-independent bound states in the continuum
Authors: Chen Shiwen , Zeng Yixuan , Li Zhongfu , Mao Yu , Dai Xiaoyu , Xiang Yuanjiang 
Published: August 2023

Abstract
Free-space nonreciprocal transmission is a crucial aspect of modern optics devices. The implementation of nonreciprocal optical devices through optical nonlinearity has been demonstrated. However, due to the weak nonlinearity of traditional materials, most self-biased nonreciprocal devices are heavily dependent on the high Q strong resonances. In general, these resonances are frequently polarization sensitive. In this work, we propose ultrathin optical metasurface embedding Kerr nonlinearities to achieve nonreciprocal transmission and optical bistability for free-space propagation based on symmetry-protected bound states in the continuum (BICs). Since the structure of the metasurface retains C4ν symmetry, the symmetry-protected BIC is polarization-independent. It is also shown that the nonreciprocal intensity range could be largely tuned by the structure parameters. The demonstrated devices merge the field of nonreciprocity with ultrathin metasurface technologies making this design an exciting prospect for an optical switch, routing, and isolator with optimal performance.
Two-photon interference from silicon-vacancy centers in remote nanodiamonds
Authors: Waltrich Richard , Klotz Marco , Agafonov Viatcheslav N. , Kubanek Alexander 
Published: August 2023

Abstract
The generation of indistinguishable photons is a key requirement for solid-state quantum emitters as a viable source for applications in quantum technologies. Restricting the dimensions of the solid-state host to a size well below the wavelength of light emitted by a defect-center enables efficient external optical coupling, for example, for hybrid integration into photonic devices. However, stringent restrictions on the host dimensions result in severe limitations on the spectral properties reducing the indistinguishability of emitted photons. Here, we demonstrate two-photon interference from two negatively charged silicon-vacancy centers located in remote nanodiamonds. The Hong–Ou–Mandel interference efficiency reaches 61 % with a coalescence time window of 0.35 ns. We furthermore show a high yield of pairs of silicon-vacancy centers with indistinguishable optical transitions. Therefore, our work opens new paths in hybrid quantum technology based on indistinguishable single-photon emitters in nanodiamonds.
The crystal structure of diaqua-(naphthalene-4,5-dicarboxylate-1,8-dicarboxylic anhydride-κ1O)-(4′-(4-(1H-benzimidazolyl-1-yl)phenyl)-2,2′:6′,2″-terpyridine-κ
3
N,N′,N″)–manganese(II) dihydrate, C42H27MnN5O9·2H2O
Authors: Liu Xinyao , Liu Qianyu , Xiao Leijie , Fu Weiwei 
Published: August 2023

Abstract
C42H27MnN5O9·2H2O, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 12.4250(8) Å, b = 12.7259(8) Å, c = 14.2946(9) Å, α = 64.102(2)°, β = 79.774(2)°, γ = 62.453(2)°, V = 1801.9(2) Å3, Z = 2, R
gt(F) = 0.0344, wR
ref(F
2) = 0.0951, T = 150 K.
Introduction: The Global 1970s from a History of Emotions Perspective
Authors: Barua Rukmini , Moine Caroline , Oberländer Alexandra , Wambach Julia 
Published: August 2023

Abstract
The 1970s have been identified through a range of emotional markers. This special issue critically analyzes the emotional history of this decade through a global perspective. In doing so, the contributions in this issue consider the different registers and scales at which emotions were experienced, perceived, and discussed. Drawing on discussions of gay liberation struggles in Latin America, decolonial movements in Palestine, the New International Economic Order, the North American Left, and forms of post-imperialist belonging in New Zealand and Australia, we detail how new emotional communities were produced and how distinct emotionalities were shaped in conjunction with shifting global politics.
Study on properties of paper coated with Stachys floridana Shuttlew. ex Benth hemicellulose – chitosan composite solution
Authors: Li Jie , Liu Haitang , Wang Qian , Wang Yefan , Chen Lin , Jin Xin , Guo Zhihua , Wang Ting , Zhang Xinyu 
Published: August 2023

Abstract
The hemicellulose was extracted from the Stachys floridana Shuttlew. ex Benth by ultrasonic-assisted, fractional alcohol precipitation method, mixed with chitosan solution, and coated on the surface of the paper with three layers, to explore the effect of its morphology, thermal stability, barrier, mechanical properties of coated paper. The results showed that the gas barrier property of the paper coated with hemicellulose – chitosan mixed solution decreased from 180 mL/min to 0.265 mL/min, the water barrier property increased from 0 to 84.8°, and the oil barrier property increased from 0 to Kit nº11. The tearing degree of paper increased by 9.2 %, the folding resistance increased by 1296.6 %, dry and wet tensile strength and dry and wet rupture resistance were also significantly improved. The thermal stability mixed solution coated paper is slightly lower than the base paper, but higher than the pure chitosan coated paper. The prepared S. floridana Shuttlew. ex Benth hemicellulose – chitosan blend coating has good barrier property and mechanical properties, and has a wide application prospect.
Clinical importance of PCA3 lncRNA aberrant expression in chronic myeloid leukemia patients: a comparative method
Authors: He Ling , Zhang Jie , Peng Yang , Wu Hongwei , Sun Zhiqiang 
Published: August 2023

Abstract

Objectives
Long noncoding RNAs (lncRNAs) plays important role in disease spread and its invasion. Overexpression of prostate cancer antigen 3 gene (PCA3gene) is reported in prostate cancer. To analyze the PCA3 lncRNA expression in chronic myeloid leukemia (CML) patients.

Methods
The study included clinically confirmed 100 CML patients and 100 healthy subjects. Relative quantification using Sybr Green dye was used to calculate the PCA3 lncRNAs expression. Total RNA was extracted by TRIzol method and quantitative real-time polymerase chain reaction.

Results
In CML patients, 9.96 ± 4.77-folds increased noncoding PCA3 lncRNA expression was observed compared to healthy subjects. Patients of chronic phase, accelerated phase, and blast crisis phase had 4.46 ± 1.36, 7.31 ± 3.10, and 12.91 ± 4.85-fold PCA3 lncRNA expression compared to healthy subjects (p<0.0001), respectively. CML patients who have a complaint of splenomegaly had higher PCA3 lncRNA expression than those who did not complain splenomegaly compared to healthy subjects (12.04 ± 5.02-fold vs. 6.09 ± 3.39-fold, p<0.0001). Patients who had ≤20,000 TLC showed fewer PCA3 lncRNA expression than those who had >20 thousand of TLC (4.45 ± 1.84 vs. 11.25 ± 5.05, p<0.0001). Receiver operating characteristic showed correlation of PCA3 lncRNA expression with severity of cancer.

Conclusions
lncRNA PCA3 expression to be linked with different stages of the disease and a prognostic indicator for disease in CML patients.
Spleen‐targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma
Authors: Wu Ming , Luo Zijin , Cai Zhixiong , Mao Qianqian , Li Zhenli , Li Hao , Zhang Cao , Zhang Yuting , Zhong Aoxue , Wu Liming , Liu Xiaolong 
Published: August 2023

AbstractNeoantigens are emerging as attractive targets to develop personalized cancer vaccines, but their immunization efficacy is severely hampered by their restricted accessibility to lymphoid tissues where immune responses are initiated. Leveraging the capability of red blood cells (RBCs) to capture and present pathogens in peripheral blood to the antigen‐presenting cells (APCs) in spleen, we developed a RBC‐driven spleen targeting strategy to deliver DNA vaccine encoding hepatocellular carcinoma (HCC) neoantigen. The DNA vaccine‐encapsulating polymeric nanoparticles that were intentionally hitchhiked on the preisolated RBCs could preferentially accumulate in the spleen to promote the neoantigen expression by APCs, resulting in the burst of neoantigen‐specific T‐cell immunity to prevent tumorigenesis in a personalized manner, and slow down tumor growth in the established aggressively growing HCC. Remarkably, when combined with anti‐PD‐1, the vaccine achieved complete tumor regression and generated a robust systemic immune response with long‐term tumor‐specific immunological memory, which thoroughly prevented tumor recurrence and spontaneous lung metastasis. This study offers a prospective strategy to develop personalized neoantigen vaccines for augmenting cancer immunotherapy efficiency in immune “cold” HCC.
Influence of Psychosocial Characteristics on Social Media Usage among Continuing Education Learners (Cels) in Kwara State University, Malete, Nigeria
Authors: Yusuf Murtala Akanbi , Yunusa Abdullhai Abubakar , Sulaiman Kabir Alabi , Adeyemi Ismail Olatunji 
Published: August 2023

In line with the growing incursion/adoption of social media into teaching and learning, this study was conducted to understand continuing education learners’ psycho-social characteristics and their influence on their social media. A quantitative research design approach using an online Google form with 388 participants was adopted. Descriptive statistics, t-test and ANOVA were used. Results revealed that the students mostly used Facebook as their major social media platform for connecting with friends and family along with WhatsApp, Twitter, and Instagram. In addition, the study revealed that learners with higher self-concept and socioeconomic status are more inclined to social media usage among CELs. It is believed that the knowledge of psychosocial characteristics of CELs on their usage of social media will inform a bespoke and purposeful curriculum planning, design and implementation that optimizes the achievement of the learning objectives for different classes of the students based on their psycho-social differences.
Abstrak
Sejalan dengan semakin maraknya penggunaan/adopsi media sosial ke dalam proses belajar mengajar, penelitian ini dilakukan untuk memahami karakteristik psiko-sosial peserta didik pendidikan lanjutan dan pengaruhnya terhadap media sosial mereka. Pendekatan desain penelitian kuantitatif menggunakan formulir Google online dengan 388 peserta diadopsi. Statistik deskriptif, uji-t dan ANOVA digunakan. Hasil penelitian menunjukkan bahwa sebagian besar siswa menggunakan Facebook sebagai platform media sosial utama mereka untuk terhubung dengan teman dan keluarga bersama dengan WhatsApp, Twitter, dan Instagram. Selain itu, penelitian ini mengungkapkan bahwa pelajar dengan konsep diri dan status sosial ekonomi yang lebih tinggi lebih cenderung menggunakan media sosial di kalangan CEL. Diyakini bahwa pengetahuan tentang karakteristik psikososial CELs dalam penggunaan media sosial mereka akan menginformasikan perencanaan, desain, dan implementasi kurikulum yang dipesan lebih dahulu dan bertujuan yang mengoptimalkan pencapaian tujuan pembelajaran untuk kelas siswa yang berbeda berdasarkan perbedaan psiko-sosial mereka.