bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of location, season and time of day on the spectral composition of ambient light: Investigation for application in myopia
Authors: Dhakal Rohit , Huntjens Byki , Shah Rakhee , Lawrenson John G. , Verkicharla Pavan K. 
Published: January 2023

AbstractPurposeGiven the possible role of spectral composition of light and myopia, this study aimed at investigating the variation in the spectral composition of ambient light in different (a) outdoor/indoor locations, (b) time of a day and (c) seasons.MethodsThe spectral power distribution (SPD), categorised into short (380–500 nm), middle (505–565 nm) and long wavelengths (625–780 nm), was recorded using a handheld spectrometer at three outdoor locations (‘open playground’, ‘under shade of tree’ and ‘canopy’) and three indoor locations (‘room with multiple windows’, ‘closed room’ and ‘closed corridor’). Readings were taken at five different time points (3‐h intervals between 6:30 and 18:00 hours) on two days, each during the summer and monsoon seasons.ResultsThe overall median SPD (IQR [25th‐75th percentile] W/nm/m2) across the three outdoor locations (0.11 [0.09, 0.12]) was 157 times higher than that of the indoor locations (0.0007 [0.0001, 0.001]). Considerable locational, diurnal and seasonal variation was observed in the distribution of the median SPD value, with the highest value being recorded in the ‘open playground’ (0.27 [0.21, 0.28]) followed by ‘under shade of tree’ (0.083 [0.074, 0.09]), ‘canopy’ (0.014 [0.012, 0.015]) and ‘room with multiple windows’ (0.023 [0.015, 0.028]). The relative percentage composition of short, middle and long wavelengths was similar in both the outdoor and indoor locations, with the proportion of middle wavelengths significantly higher (p < 0.01) than short and long wavelengths in all the locations, except ‘canopy’.ConclusionIrrespective of variation in SPD values with location, time, day and season, outdoor locations always exhibited significantly higher spectral power than indoor locations. The relative percentage composition of short, middle and long wavelengths of light was similar across all locations. These findings establish a foundation for future research to understand the relationship between spectral power and the development of myopia.
Dynamics of mother‐infant parasympathetic regulation during face‐to‐face interaction: The role of maternal emotion dysregulation
Authors: Gao Mengyu (Miranda) , Vlisides‐Henry Robert D. , Kaliush Parisa R. , Thomas Leah , Butner Jonathan , Raby K. Lee , Conradt Elisabeth , Crowell Sheila E. 
Published: January 2023

AbstractThe dynamics of parent‐infant physiology are essential for understanding how biological substrates of emotion regulation are organized during infancy. Although parent‐infant physiological processes are dyadic in nature, research is limited in understanding how one person's physiological responses predict one's own and as well as the other person's responses in the subsequent moment. In this study, we examined mother‐infant respiratory sinus arrhythmia (RSA) dynamics during the Still‐Face Paradigm (SFP) among 106 mothers (Mage = 29.54) and their 7‐month‐old infants (55 males). Given mothers' role in shaping dyadic interactions with their infant, we also tested how mothers' self‐reported emotion dysregulation (measured via the Difficulties in Emotion Regulation Scale) associated with these dynamics. Results showed that both mothers' and infants' RSA tended to return to their respective homeostatic points (i.e., exhibited return strength) during each SFP episode, indicating stability in RSA for mother‐infant dyads. Significant shifts in mother and infant RSA return strength were observed across SFP episodes, highlighting the role of contextual demands on each individual's physiological dynamics. Mother‐infant RSA dynamics varied as a function of maternal self‐reported emotion dysregulation. Specifically, RSA levels of infants with more dysregulated mothers had a weaker tendency to return to homeostasis during the Reunion episode and were less affected by their mothers' RSA during the Still‐Face and Reunion episodes of the SFP, suggesting a less effective coregulatory influence. Our findings have implications for the intergenerational transmission of emotion dysregulation via mother‐infant physiological dynamics.
Sentinel lymph node mapping with computed tomography lymphography for mast cell tumours and a comparison between regional and sentinel lymph node histological status: Sixty‐two cases
Authors: Ferraris Erica Ilaria , Olimpo Matteo , Giacobino Davide , Manassero Luca , Iussich Selina , Lardone Elena , Camerino Mariateresa , Buracco Paolo , Morello Emanuela Maria 
Published: January 2023

AbstractIt is known that the regional lymph node (RLN) may not correspond to the sentinel lymph node (SLN) (the first lymph node draining the tumour), and many diagnostic techniques have recently been aimed at its detection. Although lymphoscintigraphy is the gold standard in both human and veterinary medicine for SLN mapping, it is relatively unavailable in veterinary medicine due to costs and difficult management of the radiotracer. This prospective study evaluated, as a first aim, the feasibility and sensitivity of the computed tomography lymphography (CTL) in detecting the SLN in 62 mast cell tumours (MCTs). The second aim was to evaluate the accuracy of the CTL in identifying the most representative lymph node of the patient's lymphatic status; the histological status of the SNL was compared with that of the RLN, to see in how many cases the patient's stage would have changed according to the RLN. When the RLN turned out to be also the SLN it was decided to excise, as a control LN, the one localised in the neighbourhood of the MCT (neighbouring lymph node; NLN). The detection rate was 90%, with failure of SLN identification in six cases. In 18 (32%) of 56 MCTs with a diagnostic CTL, the SLN did not correspond to the RLN. Forty‐five MCTs were surgically removed, together with their corresponding SLN and RLN/NLN. Since the clinical stage of the patient would have changed in only 7% of cases, CTL is a reliable method of detecting the SLN and, for staging purposes, there is no need to remove other LNs.
Aging is a Side Effect of the Ontogenesis Program of Multicellular Organisms
Authors: Salnikov Lev 
Published: January 2023

Abstract
The review presents a brief outline of the current state of the main theoretical approaches to the aging problem. The works of authors, supporting the theory of “accumulation of errors” and theories stating the presence of a hypothetical “aging program” in all multicellular organisms are reviewed. The role of apoptosis and its connection with phenoptosis, as well as the theory of “hyperfunction” are analyzed. Our own approach to this problem is presented, in which aging is explained by the redistribution of limited resources between the two main aims of the organism: its self-sufficiency, based on the function of the housekeeping genes (HG) group, and functional specialization, provided by the integrative genes (IntG) group. Agreeing with the inseparable connection between aging and the ontogenesis program, the main role in the aging mechanisms is assigned to the redistribution of resources from the HG self-sufficiency genes to the IntGs necessary for the operation of all specialized functions of the organism as a whole. The growing imbalance between HGs and IntGs with age, suggests that switching of cellular resources in favor of IntGs is a side effect of ontogenesis program implementation and the main reason for aging, inherent in the nature of genome functioning under conditions of highly integrated multicellularity. The hypothesis of functional subdivision of the genome also points to the leading role of slow-dividing and postmitotic cells, as the most sensitive to reduction of repair levels, for triggering and realization of the aging process.
Evaluation of the Role of Soybean Lecithin, Egg Yolk Lecithin, and Krill Oil in Promoting Ovarian Development in the Female Redclaw Crayfish Cherax quadricarinatus
Authors: Xu Chang , Yang Xiaolong , Liang Zhenye , Jiang Zongzheng , Chen Hu , Han Fenglu , Jia Yongyi , Li Erchao 
Published: January 2023

The optimal supplementation of lipid nutrients in the diet showed crucial physiological functions in gonadal development and maturation in adult female aquatic animals. Four isonitrogenous and isolipidic diets with no extra lecithin supplementation (control), 2% soybean lecithin (SL), egg yolk lecithin (EL), or krill oil (KO) supplementation were formulated for Cherax quadricarinatus (

72.32
±
3.58

g

). Ovary development and physiological characteristics of crayfish were evaluated after a 10-week feeding trial. The results indicated that SL, EL, or KO supplementation all significantly increased the gonadosomatic index, especially in the KO group. Crayfish fed the diet with SL showed the highest hepatosomatic index compared with those fed the other experimental diets. KO was more efficient than SL and EL in promoting triacylglycerol and cholesterol deposition in the ovary and hepatopancreas but also showed the lowest concentration of low-density lipoprotein cholesterol in the serum. KO significantly increased yolk granule deposition and accelerated oocyte maturation than other experimental groups. Furthermore, dietary phospholipids significantly enhanced the gonad-stimulating hormone concentration in the ovary and reduced the secretion of gonad-inhibiting hormones in the eyestalk. KO supplementation also significantly improved organic antioxidant capacity. From the ovarian lipidomics results, phosphatidylcholine and phosphatidylethanolamine are two main glycerophospholipids that respond to different dietary phospholipids. Polyunsaturated fatty acids (especially C18:2n-6, C18:3n-3, C20:4n-6, C20:5n-3, and C22:6n-3) were pivotal participants during ovarian development of crayfish regardless of lipid type. Combined with the ovarian transcriptome, the best positive function of KO was due to activated steroid hormone biosynthesis, sphingolipid signaling, retinol metabolism, lipolysis, starch and sucrose metabolism, vitamin digestion and absorption, and pancreatic secretion. As a consequence, dietary supplementation with SL, EL, or KO all improved the ovarian development quality of C. quadricarinatus, especially KO, which was the optimum choice for promoting ovary development in adult female C. quadricarinatus.
Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy
Authors: Ran Xue-Bin , Ding Ling-Wen , Sun Qiao-Yang , Yang Henry , Said Jonathan W. , Zhentang Lao , Madan Vikas , Dakle Pushkar , Xiao Jin-Fen , Loh Xinyi , Li Ying , Xu Liang , Xiang Xiao-Qiang , Wang Ling-Zhi , Goh Boon Cher , Lin De-Chen , Chng Wee Joo , Tan Soo-Yong , Jha Sudhakar , Koeffler H. Phillip 
Published: January 2023

AbstractDespite the remarkable clinical responses achieved with immune checkpoint blockade therapy, the response rate is relatively low and only a subset of patients can benefit from the treatment. Aberrant RNA accumulation can mediate IFN signaling and stimulate an immune response, suggesting that targeting RNA decay machinery might sensitize tumor cells to immunotherapy. With this in mind, we identified an RNA exoribonuclease, XRN1, as a potential therapeutic target to suppress RNA decay and stimulate antitumor immunity. Silencing of XRN1 suppressed tumor growth in syngeneic immunocompetent mice and potentiated immunotherapy efficacy, while silencing of XRN1 alone did not affect tumor growth in immunodeficient mice. Mechanistically, XRN1 depletion activated IFN signaling and the viral defense pathway; both pathways play determinant roles in regulating immune evasion. Aberrant RNA-sensing signaling proteins (RIG-I/MAVS) mediated the expression of IFN genes, as depletion of each of them blunted the elevation of antiviral/IFN signaling in XRN1-silenced cells. Analysis of pan-cancer CRISPR-screening data indicated that IFN signaling triggered by XRN1 silencing is a common phenomenon, suggesting that the effect of XRN1 silencing may be extended to multiple types of cancers. Overall, XRN1 depletion triggers aberrant RNA-mediated IFN signaling, highlighting the importance of the aberrant RNA-sensing pathway in regulating immune responses. These findings provide the molecular rationale for developing XRN1 inhibitors and exploring their potential clinical application in combination with cancer immunotherapy.Significance:Targeting XRN1 activates an intracellular innate immune response mediated by RNA-sensing signaling and potentiates cancer immunotherapy efficacy, suggesting inhibition of RNA decay machinery as a novel strategy for cancer treatment.
Regional Persistent Extreme Precipitation Events over Southwest China under Different Low-Latitude Intraseasonal Oscillations during the Rainy Season
Authors: Nie Yanbo , Sun Jianqi 
Published: January 2023

Abstract
This study investigates the mechanisms of low-latitude intraseasonal oscillations affecting regional persistent extreme precipitation events (RPEPEs) over Southwest China (SWC) during rainy seasons. Most of the RPEPEs over SWC are dominated by 7–20-day variability. The RPEPEs over SWC are preconditioned by two different types of 7–20-day Rossby waves with almost opposite phases over the western North Pacific (WNP). The two types of 7–20-day Rossby waves have direct and indirect effects on type-1 and -2 RPEPEs, respectively. For type 1, a coupled 7–20-day low-level anticyclone and suppressed convection originating from the tropical WNP propagate northwestward and cover the region from the South China Sea (SCS) to the Bay of Bengal before the RPEPEs. The anticyclone triggers ascending motion over SWC and transports more moisture to SWC, favoring the SWC RPEPEs. Before the type-2 RPEPEs, a coupled 7–20-day low-level cyclone and enhanced convection propagates from the tropical WNP to the SCS. The enhanced convection over the SCS leads to the westward extension of the western Pacific subtropical high (WPSH) and the eastward shift of the South Asian high (SAH). The variations in the WPSH and the SAH directly cause SWC RPEPEs by inducing ascending motion and transporting moisture. The mechanisms for type-2 RPEPEs tend to work under the background with a strong WPSH. Using a Lagrangian model, we found that both the 7–20-day oscillations and their background atmospheric circulations result in significant differences in moisture sources for the two types of RPEPEs. These findings benefit a better understanding of SWC extreme precipitation events.
Transcranial sonography with clinical and demographic characteristics to predict cognitive impairment in PD: a longitudinal study
Authors: Chen Zhiguang , Zhang Wei , He Wen , Guang Yang , Yu Tengfei , Du Yue , Li Rui 
Published: January 2023

Abstract
Background
Parkinson’s disease (PD) is a neurodegenerative disease and is clinically characterized by a series of motor symptoms (MS) and nonmotor symptoms (NMS). NMS often appear before MS, while cognitive impairment mostly occurs within a few years after the diagnosis of PD. Therefore, we aimed to predict the risk factors for cognitive impairment (CI) in PD patients based on transcranial sonography, clinical symptoms, and demographic characteristics.

Methods
Based on the occurrence time of CI, a total of 172 PD patients were divided into non-CI (N-CI, n = 48), CI at the first treatment (F-CI, n = 58), and CI at the last treatment (L-CI, n = 66) groups. Clinical data (including MS and NMS) and ultrasonic data of all patients at the first treatment and the last treatment were collected retrospectively. Independent samples t tests were used to compare continuous data, and chi-square tests were used to compare categorical data. The risk factors for CI and Parkinson’s disease dementia were identified by logistic regression analysis, and an ROC curve was established to explore the diagnostic efficacy.

Results
1) The age of onset, first treatment and smoking history of CI patients were significantly different from those of N-CI patients. When age of first treatment ≥61 years was considered the boundary value to diagnose CI, the sensitivity and specificity were 77.40 and 66.70%, respectively. 2) The severity of depression was significantly different between F-CI and N-CI patients at the first treatment, while the cumulative and new or aggravated memory deficit was significantly different between the L-CI and N-CI patients at the last treatment. 3) There was a significant difference in TCS grading between the first and last treatment in L-CI patients. 4) Depression, sexual dysfunction, and olfactory dysfunction in NMS were independent risk factors for CI during the last treatment. 5) The sensitivity and specificity of predicting CI in PD patients were 81.80 and 64.60%, respectively.

Conclusions
PD patients with CI were older, and most of them had a history of smoking. Furthermore, there was good diagnostic efficiency for predicting CI in PD via TCS combined with clinical characteristics (especially NMS).
The antimicrobial efficacy of graphene oxide, double antibiotic paste, and their combination against Enterococcus faecalis in the root canal treatment
Authors: Eskandari Fateme , Abbaszadegan Abbas , Gholami Ahmad , Ghahramani Yasamin 
Published: January 2023

Abstract
Background
Inter-appointment medication of the root canals with appropriate intracanal medicaments has been advocated to improve root canal disinfection. Graphene oxide (GO) has shown promising antimicrobial activity against a wide range of microorganisms, besides the capability of carrying antibiotics. The current study aimed to compare the antibacterial activity of double antibiotic paste (DAP) and GO per se and in combination (GO-DAP) against Enterococcus faecalis (E. faecalis).

Methods
A total of 108 extracted human mandibular premolars were contaminated with three-week-old E. faecalis and subjected to a primary microbial assessment. The samples were categorized into 15 groups concerning the intracanal medicament (DAP, GO, GO-DAP, and control) and contact time (1, 7, and 14 days). Then, the root canals were medicated, incubated, and resubjected to a secondary antimicrobial evaluation. The colony-forming units (CFU) were counted to calculate the antimicrobial efficacy. The data were analyzed via the Kruskal–Wallis test (α = 0.05).

Results
GO-DAP was the only medicament that completely eradicated E. faecalis in 1 day. The percentage reduction of CFU/ml in the GO-DAP and DAP groups was higher than that in the GO group at all allocated contact times. Furthermore, a significant decrease of the CFU/ml was seen in the GO and DAP groups after 7 and 14 days of being medicated (P < 0.05).

Conclusion
Since GO-DAP improved root canal disinfection, this novel material can be introduced as a promising intracanal medicament against E. faecalis even in the short run.
Transformational leadership in development of transformative education in nursing: a qualitative study
Authors: Ghorbani Azam , Mohammadi Nooredin , Rooddehghan Zahra , Bakhshi Fatemeh , Nasrabadi Alireza Nikbakht 
Published: January 2023

Abstract
Background
Regarding the dynamic and increasing needs of communities, changes in the education system are essential to train competent healthcare professionals. The study aimed to explore the experience of educational directors, teachers, and students to gain insight into the implementation of educational transformative programs.

Method
A qualitative approach with the grounded theory method was applied in this study. Twenty-four participants were selected by using a purposive and theoretical sampling method. The data were collected from April 2019 to May 2020 in nursing schools of Tehran, through in-depth semi-structured individual face-to-face interviews and field notes. Collected data were analyzed by Corbin and Strauss’s (2015) approach.

Results
In this study, transformational leadership was extracted as the core concept. The core concept emerged from four sub-concepts including transformative management; educational policy requirements; providing a platform and community-centered education.

Conclusions
Nurse educational directors need to achieve some competencies and capabilities for implementing transformative education in nursing schools. Also, achieving a transformative perspective by educational directors is essential.
Qualitative risk assessment of homogeneity, stability, and residual concentrations of antimicrobials in medicated feed and drinking water in pig rearing
Authors: Georgaki Despoina , Vandael Femke , Cardoso de Carvalho Ferreira Helena , Filippitzi Maria Eleni , De Backer Patrick , Devreese Mathias , Dewulf Jeroen , Croubels Siska 
Published: January 2023

AbstractBackgroundDespite the common use of oral group treatment in pig rearing, the magnitude of the factors influencing the homogeneity and stability of antimicrobial drugs in medicated feed and medicated drinking water are largely unknown, as well as the residual concentrations of the drugs after the end of the treatment.ResultsThis study presents a qualitative risk assessment to estimate the magnitude of the risks for reduced homogeneity and stability, and increased residual concentrations of antimicrobial drugs in medicated feed and drinking water on the farm. Risk assessment was done using a questionnaire and farm visits (n = 52), combined with a second questionnaire, and concentrations of amoxicillin and doxycycline measured in medicated feed and water samples, each collected on 10 farms.For medicated feed, the duration of storage in the silo did not show to influence the concentration levels in a consistent trend, while the treatment duration had a low to negligible effect. A moderate to high risk was found caused by human error when preparing the medicated feed on the farm. Purchased medicated feed greatly reduces the risk of human error and drugs remain stable during the duration of treatment, while the risk of residual concentrations after the end of the treatment was estimated to be low to moderate. The feed intake variability was identified as a moderate to high risk factor.For medicated drinking water, the type of dosing pump, age of pre-solution, and human errors during the preparation of the pre-solution present a moderate to high risk on homogeneity and stability. Precipitation of the active substance in the absence of a stirrer in a drinking water tank was shown to be a low to moderate risk factor for residues after treatment. Waterline length had a weak correlation with the concentrations of the antimicrobials, while a moderate to high influence was detected for the water intake by the pigs.ConclusionsA considerable variation in drug concentration in both medicated feed and medicated drinking water was detected depending on their preparation. Therefore, it is important to know which factors influence the homogeneity and stability, and the residual concentrations after treatment.