bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation
Authors: Mattingly Madison L. , Ruple Bradley A. , Sexton Casey L. , Godwin Joshua S. , McIntosh Mason C. , Smith Morgan A. , Plotkin Daniel L. , Michel J. Max , Anglin Derick A. , Kontos Nicholas J. , Fei Shengyi , Phillips Stuart M. , Mobley C. Brooks , Vechetti Ivan , Vann Christopher G. , Roberts Michael D. 
Published: September 2023

Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking. Thus, we adopted a multi-faceted approach to examine if acute and subchronic resistance training (RT) altered skeletal muscle protein lactylation levels. In mice, we also sought to examine if surgical ablation-induced plantaris hypertrophy coincided with increases in muscle protein lactylation. To examine acute responses, participants’ blood lactate concentrations were assessed before, during, and after eight sets of an exhaustive lower body RT bout (n = 10 trained college-aged men). Vastus lateralis biopsies were also taken before, 3-h post, and 6-h post-exercise to assess muscle protein lactylation. To identify training responses, another cohort of trained college-aged men (n = 14) partook in 6 weeks of lower-body RT (3x/week) and biopsies were obtained before and following the intervention. Five-month-old C57BL/6 mice were subjected to 10 days of plantaris overload (OV, n = 8) or served as age-matched sham surgery controls (Sham, n = 8). Although acute resistance training significantly increased blood lactate responses ∼7.2-fold (p &lt; 0.001), cytoplasmic and nuclear protein lactylation levels were not significantly altered at the post-exercise time points, and no putative lactylation-dependent mRNA was altered following exercise. Six weeks of RT did not alter cytoplasmic protein lactylation (p = 0.800) despite significantly increasing VL muscle size (+3.5%, p = 0.037), and again, no putative lactylation-dependent mRNA was significantly affected by training. Plantaris muscles were larger in OV versus Sham mice (+43.7%, p &lt; 0.001). However, cytoplasmic protein lactylation was similar between groups (p = 0.369), and nuclear protein lactylation was significantly lower in OV versus Sham mice (p &lt; 0.001). The current null findings, along with other recent null findings in the literature, challenge the thesis that lactate has an appreciable role in promoting skeletal muscle hypertrophy.
Mad or mad-mad: conveying subtle emotion with face emoji
Authors: Upadhyay Sri Siddhi N. , Gunraj Danielle N. , Phillips Nicklas C. 
Published: September 2023

Introduction: To compensate for the lack of pragmatic information available when communicating via text message, texters make frequent use of texting-specific cues, or textisms, to convey meaning that would otherwise be apparent in spoken conversation. Here, we explore how one such cue, face emoji, can impact the interpretation of text messages.Methods: In Experiment 1, we paired neutral text messages with valenced face emoji to determine whether the emoji can alter the meaning of the text. In Experiment 2, we paired valenced text messages with valenced face emoji to determine whether the emoji can modulate the valence of the text.Results: In Experiment 1, we found that texts paired with positive emoji were rated more positively than texts paired with negative emoji. Furthermore, texts paired with stronger-valenced emoji were rated as less neutral compared to texts paired with milder-valenced emoji. In Experiment 2, we found that slightly positive texts paired with strong positive emoji were rated somewhat similarly to the same texts paired with mild positive emoji; however, slightly negative texts paired with strong negative emoji were rated much more negatively than the same texts paired with mild negative emoji.Discussion: These results indicate that the presence of face emoji, particularly negative face emoji, can alter the interpretation of text messages, allowing texters to communicate nuanced meaning and subtle emotion.
Interactive effects of sleep and physical activity on depression among rural university students in China
Authors: Yang Yang , Zhang Zhen , Liu Jia , Cao Hongmin 
Published: September 2023

BackgroundDecreased sleep quality and physical activity among university students have become important concerns, while depressive symptoms are on the rise, especially in rural areas. Previous studies have confirmed the association between sleep quality and physical activity and depressive symptoms, but the effect of their interaction on depressive symptoms has been less studied. For this reason, the present study analyzed the interaction between sleep quality and physical activity on depressive symptoms to provide reference and assistance for mental health promotion and intervention for university students in rural areas of China.MethodsIn this study, we investigated sleep quality, physical activity, and depressive symptoms in 11,423 university students in rural areas of China. The association of sleep quality and physical activity with depressive symptoms was analyzed by using univariate analysis and logistic regression analysis. And further analyzed the association between the interaction effect of sleep quality and physical activity and depressive symptoms.ResultsThe proportion of university students with depressive symptoms in rural China was 33.3%, with a higher proportion of girls students (36.7%) having depressive symptoms than boys students (28.8%). Logistic regression analysis of the interaction between sleep quality and physical activity and depressive symptoms in university students showed that university students with poor sleep quality and MVPA&gt;60 min/d (OR = 4.40,95% CI: 3.75–5.05) had the highest risk of depressive symptoms (p &lt; 0.001). University students with moderate sleep quality and MVPA of 30–60 min/d (OR = 1.18, 95% CI: 0.75–1.61) had the lowest risk of depressive symptoms (p &lt; 0.001). Moreover, there was no gender difference in this result.ConclusionThe prevalence of depressive symptoms was higher among university students in rural areas of China. There was an interaction between sleep quality and MVPA on depressive symptoms, maintaining a good quality of sleep and an appropriate length of MVPA has a contributory effect on mental health, and the same trend was found for both boys and girls students. It is recommended that university students in rural areas of China should first maintain proper sleep quality while maintaining 30–60 min of MVPA per day, which may reduce the risk of depressive symptoms.
Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells
Authors: Fan Lei , Ren Jinlian , Wang Yinchu , Chen Yiyi , Chen Yichun , Chen Libin , Lin Qiuyan , Liao Ming , Ding Chan , Xiang Bin , Ren Tao 
Published: September 2023

IntroductionNewcastle disease virus (NDV) is prevalent worldwide with an extensive host range. Among birds infected with velogenic NDV strains, chickens experience high pathogenicity and mortality, whereas ducks mostly experience mild symptoms or are asymptomatic. Ducks have a unique, innate immune system hypothesized to induce antiviral responses. Circular RNAs (circRNAs) are among the most abundant and conserved eukaryotic transcripts. These participate in innate immunity and host antiviral response progression.MethodsIn this study, circRNA expression profile differences post-NDV infection in duck embryo fibroblast (DEF) cells were analyzed using circRNA transcriptome sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to reveal significant enrichment of differentially expressed (DE) circRNAs. The circRNA-miRNA-mRNA interaction networks were used to predict the related functions of circRNAs. Moreover, circ-FBXW7 was selected to determine its effect on NDV infection in DEFs.ResultsNDV infection altered circRNA expression profiles in DEF cells, and 57 significantly differentially expressed circRNAs were identified post-NDV infection. DEF responded to NDV by forming circRNAs to regulate apoptosis-, cell growth-, and protein degradation-related pathways via GO and KEGG enrichment analyses. circRNA-miRNA-mRNA interaction networks demonstrated that DEF cells combat NDV infection by regulating cellular pathways or apoptosis through circRNA-targeted mRNAs and miRNAs. circ-FBXW7 overexpression and knockdown inhibited and promoted viral replication, respectively. DEF cells mainly regulated cell cycle alterations or altered cellular sensing to combat NDV infection.ConclusionThese results demonstrate that DEF cells exert antiviral responses by forming circRNAs, providing novel insights into waterfowl antiviral responses.
Pluralizm w edukacji językowej – konceptualizacje, implikacje dydaktyczne
Authors: Krasuska-Betiuk Marta 
Published: September 2023

Artykuł ma charakter metajęzykowej refleksji na temat potencjału dydaktycznego plurilingwalizmu a jego celem jest prezentacja założeń koncepcyjnych wybranych pluralistycznych koncepcji edukacji językowej, które lingwiści określają mianem plurilingual pedagogies. To grupa podejść metodologiczno-teoretycznych i praktycznych, uznawanych nie tylko za innowacyjne, wartościowe i skuteczne ale też konieczne do zastosowania we współczesnej edukacji. I chociaż różnojęzyczność funkcjonuje w polskim systemie w placówkach dwujęzycznych i międzynarodowych, w formie koncepcji dydaktycznych, programów lub rozwiązań metodycznych, autorka dostrzega potrzebę jej szerszego wykorzystania, implementację do codziennej praktyki szkolnej, w obecnych czasach , gdy każde dziecko jest w procesie dochodzenia do określonego poziomu dwujęzyczności a każdy nauczyciel jest nauczycielem języka. W artykule przedstawiono najważniejsze podejścia: prulilingualism, translanguanging i language awareness, które są stosowane w codziennej praktyce językowej rodzin i społeczności wielojęzycznych oraz mają zastosowanie w różnojęzycznych grupach, klasach, w pracy z dziećmi z doświadczeniem migracji.
Editorial: Passion in Human Education
Authors: Kaczor Agnieszka , Szymańska Maria 
Published: September 2023

Issues related to the passion in upbringing, or education, appear more and more often in the epistemological, empirical and practical space, which indicates its importance for human functioning in the world, for building relationships with self, others, and God. Passion often is described as a motivating force that dynamize a person to act. It seems to be a factor enabling the man to get the wider knowledge of “Self". It also fosters developing autonomous identity; provokes reflection; strengthens the power of will and commitment in performing different tasks, despite the difficulties that must be overcome, especially, when it concerns harmonious passion (H.P.) - described more extensively in the works of Robert J. Vallerand. Considering the importance of passion in human life, particularly, in educational area, on behalf of the entire Editorial Boardwe invite our Readers to familiarize themselves with the contents of this issue of Horisons of Education.
Perception of Oneself as a Teacher from the Perspective of Individuals Retraining for the New Profession
Authors: Łukasik Joanna 
Published: September 2023

RESEARCH OBJECTIVE: The purpose of this article is to identify and describe the self-perceptions of those retraining and preparing for the teaching profession.
THE RESEARCH PROBLEM AND METHODS: The research problem was formulated as follows: how do postgraduate students who are retraining to become teachers perceive themselves as future teachers? Data were obtained from postgraduate students who wrote essays on Why did I choose to study teacher training and what kind of teacher would I like to be? The method of qualitative text analysis was used to analyze the essays, which were treated as secondary data.
THE PROCESS OF ARGUMENTATION: The first part of the article focuses on the importance of positive self-image and self-concept in motivation for development, as they strengthen self-esteem, and translate it into attitudes and inner containment. In the empirical section, based on Leary’s concept, three main categories were identified.
RESEARCH RESULTS: The analysis shows that the respondents’ project of themselves in the professional role of a teacher is declarative only. The categories and qualities that the respondents mentioned refer both to their negative (by contrast) and positive school experiences. Positive self-perception through the characteristics described, experiences of working in other professions and passions all motivate positive work on oneself and are a condition for becoming a teacher.
CONCLUSION, INNOVATIONS, RECOMMENDATIONS: In the final conclusions, a proposal was made for a new way of recruiting and temporary qualification for the teaching profession. Attention was paid to strengthening intrinsic motivation to work on one’s development as a prerequisite for preparing for work and becoming a teacher.
APLICACIÓN DEL MAPEO PARTICIPATIVO DE RIESGOS EN UN ESTUDIO DE PERCEPCIÓN SOCIAL DE RIESGOS ECOLÓGICOS
Authors: José Renato de Nóbrega Suárez  , Teresa Carolina Delucca Rosales  
Published: September 2023

Se desarrolló una investigación para caracterizar la percepción social de las principales amenazas que podrían afectar un ambiente acuático particular- una laguna costera- mediante la aplicación de una versión del método denominado mapeo participativo de riesgos, más sencillo que el método del paradigma psicométrico tradicionalmente utilizado. Consiste en entrevistas en las que el interrogado comenta sobre los principales problemas o amenazas ambientales que percibe y los jerarquiza según tres criterios: gravedad, urgencia y control. De cada categoría de amenaza identificada se obtuvo el índice de incidencia- la fracción de entrevistados que citaron la categoría problema – y los índices de gravedad, urgencia y control. Con estos índices se elaboran mapas gráficos de percepción de las amenazas según cada criterio. El método se aplicó a un grupo de pescadores que hacen uso de la laguna, los cuales perciben cinco (5) problemas ambientales: el desvío de ríos, la obstrucción de ríos y el cierre temporal de la boca de conexión de la laguna con el mar (casos particulares de la hidrodinámica alterada), el crecimiento excesivo del mangle y la pesca de peces juveniles; estos dos últimos son percibidos como los de mayor facilidad en controlar. Se demuestran las bondades del método.
ANÁLOGOS DO GLP-1 E NEUROPROTEÇÃO: UMA REVISÃO SISTEMÁTICA
Authors: Castro Júlia Vasconcellos , Cruz Thainá Baltazar Ferreira da , Fonseca Isabela Oliveira , Tostes Glauce Cordeio Ulhôa 
Published: September 2023

O Diabetes Mellitus 2 (DM2) é uma doença crônica de incidência crescente, resultando em aumento de morbimortalidade devido a complicações associadas, dentre elas estão a neurodegeneração e as alterações estruturais cerebrais, relacionadas à resistência insulínica e hiperglicemia. Os hormônios insulinotrópicos, como os agonistas do receptor GLP-1, estimulam a secreção de insulina e regulam a glicemia. A ativação central do GLP-1R reduz o apetite e o peso corporal, aumentando a fosforilação de PKA e MAPK e diminuindo a atividade de AMPK no núcleo do trato solitário. Esses impactos incluem o aumento da proliferação de células progenitoras de neurônios, prolongamento da potenciação no hipocampo, melhora do aprendizado, diminuição do estresse oxidativo, aumento da neurogênese e da plasticidade sináptica, diminuição da neurotoxicidade, além de reduzir a formação de placas beta-amiloides e a neuroinflamação2,3. O objetivo do estudo foi analisar, por meio de uma revisão sistemática da literatura, os impactos dos análogos de GLP-1 na neuroproteção. Foi feita uma revisão da literatura nas bases de dados PudMed, Cochrane e Scielo, utilizando os descritores “GLP-1” e “neuroproteção” e suas variações segundo o MeSH. Adotou-se a escala PRISMA2 para a sistematização do estudo. Os critérios de inclusão foram ensaios clínicos controlados randomizados em humanos, em inglês. Já os critérios de exclusão foram estudos realizados em modelo animal ou que não possuíam metodologia clara ou não preenchiam os critérios de inclusão. A maioria dos artigos demonstrou que, a estimulação do GLP-1R é neurotrófica/neuroprotetora, induzindo diferenciação e crescimento celular, e fornecendo proteção contra a morte celular neuronal apoptótica induzida por glutamato, e, protege contra o estresse oxidativo e a peroxidação lipídica da membrana. Os GLP-1 RA demonstraram proteção cérebro vascular em pacientes com risco elevado para eventos, como a população diabética, e parecem ser medicações promissoras para o tratamento de doenças demenciais como Doença de Alzheimer em fases iniciais. Mais ensaios clínicos randomizados, com acompanhamento de longo prazo são necessários para uma conclusão robusta.
A formação do professor que ensina matemática na perspectiva de práticas interculturais: povos originários, quilombolas e do campo
Authors: Virgens Wellington Pereira das Virgens , Sousa Maria do Carmo de , Valle Júlio Cesar Augusto do 
Published: September 2023

Este texto apresenta uma síntese das discussões ocorridas no contexto do GD5: A Formação do Professor que Ensina Matemática na Perspectiva de Práticas Interculturais: Povos originários, Quilombolas e do Campo, durante o VIII Fórum Paulista de Formação de Professores que Ensinam Matemática, sediado pelo Campus São Paulo do Instituto Federal de Educação, Ciência e Tecnologia de São Paulo entre os dias 31/03/2023 e 01/04/2023. O GD teve como objetivo geral a promoção de discussões sobre a formação do professor que ensina matemática no contexto das relações étnico-raciais, interculturalidade, educação matemática antirracista e educação do campo. As discussões contemplaram, especialmente, elementos presentes nas práticas ensino, pesquisa e extensão que dialogam diretamente com os dispostos nas Leis 10.639/2003, 11.645/2008, e Decreto 7.352/2010, bem como o currículo escolar de matemática e suas relações com as especificidades das diferentes modalidades de ensino no que diz respeito à temática do GD. Os resultados das discussões apontam para o reconhecimento da importância da temática no contexto da formação de professores, sobretudo para potencializar práticas que colocam a aprendizagem da matemática como parte do processo de humanização que valoriza os contextos interculturais dos sujeitos envolvidos nos processos e para a superação de outras práticas que tendem a considerar a matemática como um fim em si mesma.
The Example of an Islamic Religious Education Teacher on the Awareness of Muslim Women's Dress in Middle School Students
Authors: Amrah Nurhikmah 
Published: September 2023

Purpose of the study: The aim of the research is to analyze the example of Islamic Religious Education Teachers on the Awareness of Muslim Women's Dress in Students at Junior High School Negeri 4 Panca Rijang, Sidrap Regency
Methodology: The method used is quantitative with a case study type of research, the research location is at Junior High School Negeri 4 Panca Rijang Sidrap Regency. The instrument used is a questionnaire with descriptive data analysis.
Main Findings: Based on the results of descriptive statistical analysis of questionnaire scores related to the variable awareness of Muslim women's clothing of students from 54 respondents, it is known that students who stated that awareness of Muslim women's clothing were in the very poor category were 0 (0%), students who stated that it was bad was 0 (0%) %) people, students who said it was fair were 3 (6%) people, students who said it was good were 32 (59%) people, and students who said their awareness of Muslim women's clothing was in the very good category was 19 (35% ) person.
Novelty/Originality of this study: The latest research is trying to examine the awareness of Muslim women's clothing at Junior High School Negeri 4 Panca Rijang, Sidrap Regency.
The Impact of Teachers' Personalities and Parents' Factors on Senior Secondary School Computer Science Students' Performance
Authors: Olojo Oludare Jethro 
Published: September 2023

As secondary education institutions try to educate students about the demands of a rapidly changing digital world, it is crucial to understand the factors that influence students' progress in computer science. Students' success in the study of computer science is influenced by a variety of factors outside of the curriculum and instructional methods. Two significant elements that have drawn attention in the education sector are the personalities of teachers and parental involvement. These factors play a significant role in how children learn, act, and succeed academically as a whole. To determine the effects of teachers' personalities and parental influences on senior secondary school computer science students' performance, this study was designed. The research employed a mixed-methods strategy that includes both quantitative surveys and qualitative interviews to collect information from a representative sample of the targeted demographic. A total of 150 respondents, including 100 students and 50 teachers, were chosen at random from five senior secondary schools to make up the study's sample. Four research questions and two research hypotheses served as the study's guiding principles. Data were gathered using a self-structured questionnaire the researcher constructed based on perceptions of students and teachers that examined how parents and teachers might influence students' academic progress in computer science. The four (4) research questions that were posed for the study were evaluated using descriptive statistical methods such as mean and standard deviation, whereas the two study hypotheses were evaluated using the Pearson Product Moment Correlation (PPMC) index coefficient using SPSS Version 23 at the 0.05 level of significance. The results of this study showed that factors such as teachers' academic backgrounds, personalities, and parents' socioeconomic level have an impact on students' academic success in computer science. The study's findings also indicated a correlation between parents' socioeconomic level and their children's academic success and between the qualifications of teachers and students' academic success. As a result, it was recommended among other things, that teachers be encouraged to pursue higher education because doing so will have a significant impact on how they instruct their students.
Ani İşitme Kaybında C-Reaktif Protein Albümin Oranı ve Hematolojik Parametrelerin Prognostik Değeri
Authors: YILDIZ Muhammed Gazi , ORHAN İsrafil , DOĞANER Adem 
Published: September 2023

Amaç: Çalışmanın amacı Ani İşitme Kaybının(AİK) prognozunda C reaktif protein / albümin oranı(CAO) ve hemoglobin, nötrofil, lenfosit, trombosit, ortalama trombosit hacmi(MPV), Nötrofil/Lenfosit oranı(NLO), Trombosit / Lenfosit oranı(TLO) ve Sistemik İmmun İnflamasyon İndeksi(Sİİ) gibi hematolojik parametrelerin etkisini araştırmaktır.
Gereç ve Yöntemler: Çalışma 66 AİK tanısı olan hasta grubu ve 66 sağlıklı kontrol grubu olacak şekilde planlandı. Hastaların tedavi öncesi hemogram parametreleri ve işitme testleri incelendi. Ani işitme kaybı olan hastalar tedavi sonrası iyileşenler ve iyileşmeyenler olarak sınıflandırıldı. Gruplar arası CAO ve hematolojik parametreler karşılaştırıldı.
Bulgular: Hasta grupta CRP hariç diğer parametreler istatistiksel olarak anlamlı saptandı. Recevier Operator Curve(ROC) analizinde hasta grupta NLO, TLO, Sİİ, MPV ve CAO değerlerinin AİK grubunda ayrım gücü istatistiksel olarak anlamlı idi. Ayrıca AİK grubunda iyileşmeyenlerde ise nötrofil dışındaki diğer parametreler istatistiksel olarak anlamlı idi. ROC analizinde ise NLO, TLO, Sİİ, MPV ve CAO değerleri istatistiksel anlamlı yüksek saptandı.
Sonuç: Ani işitme kaybı olan hastalarda maliyeti düşük, kolay elde edilen CAO, NLO, TLO,MPV ve Sİİ prognozun belirlenmesinde prediktif gösterge olarak kullanılabilir.