bluuebunny/crossref_metadata_2025_split huggingface dataset:
NATO’s Expansion and Russia’s Aggressiveness: An Empirical Study from the Perspective of the U.S. Public
Authors: Liu Kerry 
Published: June 2023

Abstract
Russia’s aggression on Ukraine has attracted worldwide attention. The relations between Russia’s aggression and NATO’s expansion are being debated with conflicting viewpoints. Based on weekly Google Trends data from 5 March 2017 to 13 February 2022, this study creatively creates a series of time series variables to measure the public agenda in the US. Based on time series modellings, this study finds that the U.S. public believes that there are bi-directional relations between NATO’s expansion and Russia’s aggressiveness. In particular, Russia’s aggressiveness is driven by both NATO’s expansion and Russia’s imperialism. NATO’s expansion is driven by Russia’s foreign policy, Russia’s aggressiveness, and Russia’s imperialism. These conclusions predicted the U.S. government’s policy towards this war. This study contributes to policymakers by providing solid empirical evidence on the U.S. public’s opinion on this important issue and to academia as well by presenting a (still) new quantitative method in international relations. By employing this method, we can leverage readily accessible high-frequency time series data to gain valuable insights into U.S. public opinion, potentially enabling people to predict U.S. foreign policies.
Fentanyl-Induced Respiratory Depression and Locomotor Hyperactivity Are Mediated by μ-Opioid Receptors Expressed in Somatostatin-Negative Neurons
Authors: Furdui Andreea , da Silveira Scarpellini Carolina , Montandon Gaspard 
Published: June 2023

AbstractOpioid drugs are widely used as analgesics but cause respiratory depression, a potentially lethal side effect with overdose, by acting on μ-opioid receptors (MORs) expressed in brainstem regions involved in the control of breathing. Although many brainstem regions have been shown to regulate opioid-induced respiratory depression, the types of neurons involved have not been identified. Somatostatin is a major neuropeptide found in brainstem circuits regulating breathing, but it is unknown whether somatostatin-expressing circuits regulate respiratory depression by opioids. We examined the coexpression ofSst(gene encoding somatostatin) andOprm1(gene encoding MORs) mRNAs in brainstem regions involved in respiratory depression. Interestingly,Oprm1mRNA expression was found in the majority (>50%) ofSst-expressing cells in the preBötzinger Complex, the nucleus tractus solitarius, the nucleus ambiguus, and the Kölliker–Fuse nucleus. We then compared respiratory responses to fentanyl between wild-type andOprm1full knock-out mice and found that the lack of MORs prevented respiratory rate depression from occurring. Next, using transgenic knock-out mice lacking functional MORs specifically inSst-expressing cells, we compared respiratory responses to fentanyl between control and the conditional knock-out mice. We found that respiratory rate depression by fentanyl was preserved when MORs were deleted only inSst-expressing cells. Our results show that despite coexpression ofSstandOprm1in respiratory circuits and the importance of somatostatin-expressing cells in the regulation of breathing, these cells do not mediate opioid-induced respiratory rate depression. Instead, MORs found in respiratory cell populations other thanSst-expressing cells likely contribute to the respiratory effects of fentanyl.
A Cre Driver Line for Genetic Targeting of Kappa Opioid Receptor Expressing Cells
Authors: Paliarin Franciely , Duplantis Chelsea , Jones Andrea F. , Cucinello-Ragland Jessica , Basavanhalli Samhita , Blaze Emily , Doré Evan , Neel Anna Isabella , Sun Haiguo , Chen Rong , Edwards Scott , Gilpin Nicholas W. , Messing Robert O. , Maiya Rajani 
Published: June 2023

AbstractHere we describe the generation and characterization of aCreknock-in mouse line that harbors a Cre insertion in the 3′UTR of the κ opioid receptor gene (Oprk1) locus and provides genetic access to populations of κ opioid receptor (KOR)-expressing neurons throughout the brain. Using a combination of techniques including RNAin situhybridization and immunohistochemistry, we report that Cre is expressed with high fidelity in KOR-expressing cells throughout the brain in this mouse line. We also provide evidence that Cre insertion does not alter basal KOR function. Baseline anxiety-like behaviors and nociceptive thresholds are unaltered inOprk1-Cremice. Chemogenetic activation of KOR-expressing cells in the basolateral amygdala (BLAKORcells) resulted in several sex-specific effects on anxiety-like and aversive behaviors. Activation led to decreased anxiety-like behavior on the elevated plus maze and increased sociability in female but not in maleOprk1-Cremice. Activation of BLAKORcells also attenuated KOR agonist-induced conditioned place aversion (CPA) in maleOprk1-Cremice. Overall, these results suggest a potential role for BLAKORcells in regulating anxiety-like behaviors and KOR-agonist mediated CPA. In summary, these results provide evidence for the utility of the newly generatedOprk1-Cremice in assessing localization, anatomy, and function of KOR circuits throughout the brain.
Is Short Sleep Bad for the Brain? Brain Structure and Cognitive Function in Short Sleepers
Authors: Fjell Anders M. , Sørensen Øystein , Wang Yunpeng , Amlien Inge K. , Baaré William F. C. , Bartrés-Faz David , Boraxbekk Carl-Johan , Brandmaier Andreas M. , Demuth Ilja , Drevon Christian A. , Ebmeier Klaus P. , Ghisletta Paolo , Kievit Rogier , Kühn Simone , Madsen Kathrine Skak , Nyberg Lars , Solé-Padullés Cristina , Vidal-Piñeiro Didac , Wagner Gerd , Watne Leiv Otto , Walhovd Kristine B. 
Published: June 2023

Many sleep less than recommended without experiencing daytime sleepiness. According to prevailing views, short sleep increases risk of lower brain health and cognitive function. Chronic mild sleep deprivation could cause undetected sleep debt, negatively affecting cognitive function and brain health. However, it is possible that some have less sleep need and are more resistant to negative effects of sleep loss. We investigated this using a cross-sectional and longitudinal sample of 47,029 participants of both sexes (20–89 years) from the Lifebrain consortium, Human Connectome project (HCP) and UK Biobank (UKB), with measures of self-reported sleep, including 51,295 MRIs of the brain and cognitive tests. A total of 740 participants who reported to sleep <6 h did not experience daytime sleepiness or sleep problems/disturbances interfering with falling or staying asleep. These short sleepers showed significantly larger regional brain volumes than both short sleepers with daytime sleepiness and sleep problems (n= 1742) and participants sleeping the recommended 7–8 h (n= 3886). However, both groups of short sleepers showed slightly lower general cognitive function (GCA), 0.16 and 0.19 SDs, respectively. Analyses using accelerometer-estimated sleep duration confirmed the findings, and the associations remained after controlling for body mass index, depression symptoms, income, and education. The results suggest that some people can cope with less sleep without obvious negative associations with brain morphometry and that sleepiness and sleep problems may be more related to brain structural differences than duration. However, the slightly lower performance on tests of general cognitive abilities warrants closer examination in natural settings.SIGNIFICANCE STATEMENTShort habitual sleep is prevalent, with unknown consequences for brain health and cognitive performance. Here, we show that daytime sleepiness and sleep problems are more strongly related to regional brain volumes than sleep duration. However, participants sleeping ≤6 h had slightly lower scores on tests of general cognitive function (GCA). This indicates that sleep need is individual and that sleep duration per se is very weakly if at all related brain health, while daytime sleepiness and sleep problems may show somewhat stronger associations. The association between habitual short sleep and lower scores on tests of general cognitive abilities must be further scrutinized in natural settings.
Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis
Authors: Fang Chao , Ren Pan , Bian Ganlan , Wang Jian , Bai Jiaxin , Huang Jiaxing , Ding Yixiao , Li Xueyong , Li Mingkai , Hou Zheng 
Published: June 2023

AbstractSepsis is a leading cause of in‐hospital mortality resulting from a dysregulated response to infection. Novel immunomodulatory therapies targeting macrophage metabolism have emerged as an important focus for current sepsis research. However, understanding the mechanisms underlying macrophage metabolic reprogramming and how they impact immune response requires further investigation. Here, we identify macrophage‐expressed Spinster homolog 2 (Spns2), a major transporter of sphingosine‐1‐phosphate (S1P), as a crucial metabolic mediator that regulates inflammation through the lactate‐reactive oxygen species (ROS) axis. Spns2 deficiency in macrophages significantly enhances glycolysis, thereby increasing intracellular lactate production. As a key effector, intracellular lactate promotes pro‐inflammatory response by increasing ROS generation. The overactivity of the lactate‐ROS axis drives lethal hyperinflammation during the early phase of sepsis. Furthermore, diminished Spns2/S1P signaling impairs the ability of macrophages to sustain an antibacterial response, leading to significant innate immunosuppression in the late stage of infection. Notably, reinforcing Spns2/S1P signaling contributes to balancing the immune response during sepsis, preventing both early hyperinflammation and later immunosuppression, making it a promising therapeutic target for sepsis.
Sosyal karşılaştırma eğilimin sosyal ağlardaki gösteriş tüketimi etkisinde kendini tanıtma arzusunun aracı rolü: Z kuşağı üzerinde bir araştırma
Authors: Güneş Hande , Altunışık Remzi , Sarıkaya Nilgün 
Published: June 2023

Bu çalışmanın amacı Z kuşağının, sosyal karşılaştırma eğiliminin sosyal ağlardaki gösterişçi tüketimi üzerindeki etkisinde kendini tanıtma arzusunun aracı rolü olup olmadığını araştırmaktır. Bu amaç doğrultusunda Sakarya ve İstanbul’da ikamet eden 1994 ve sonrası yıllarda doğan ve Instagram kullanan 271 kişiye yüz yüze ve çevrimiçi anket uygulanmıştır. Veri analizinde SPSS 25.0 ve AMOS 23.0 paket programları kullanılmıştır. Araştırma bulguları Z kuşağında sosyal karşılaştırma eğiliminin sosyal ağlardaki gösteriş tüketimi üzerinde etkisinde kendini tanıtma arzusunun aracılık rolü olduğu sonucunu desteklemektedir. Böylece Z kuşağının sosyal ağlarda sosyal gösteriş tüketimi eğiliminin, sosyal karşılaştırma eğilimi ve kendini tanıtma arzusu tarafından motive edildiği önermesi desteklenmiş olmaktadır.
Life Cycle Assessment (LCA) in Palm Oil Plantation and Mill with Impact Categories Global Warming Potential, Acidification, and Eutrophication
Authors: Sari Deffi Ayu Puspito , Rahmah Alifia , Sasongko Nugroho Adi 
Published: June 2023

The aims are to capture the energy and materials data used to analyze the LCA results in PT. X Study oil palm plantations and mills in Indonesia to find out which stages have the greatest impact on global warming potential (GWP), acidification, and eutrophication. The method used is the LCA approach with the CML-Baseline method. The system boundary in this research is cradle-to-gate on the plantation and mill. The data collected from January to December 2019 exclude the land-use change in plantation, liquid waste and sludge, tools used in plantation, and the amount of water used in plantation and mill, the data proceeded on Microsoft Excel and SimaPro 9.0.0.49. The inventory data collected from plantations are fertilizers, pesticides during plant maintenance, and diesel fuel for transportation, also inventory data collected from mills are electrical energy, steam energy, and diesel fuel. The greatest emissions or hotspots at the plantations are on the usage of fertilizers NPK 15-7-24+1 (384 Kg CO2 equivalent/Ton CPO for GWP, 1.93 Kg SO2 equivalent/Ton for acidification, and 0.65 Kg PO4 equivalent/Ton CPO for eutrophication). The hotspots at the mills for GWP and acidification are on the usage of steam energy boiler no.1 (1,273 Kg CO 2 equivalent/Ton CPO and 10.4 Kg SO 2 equivalent/Ton CPO respectively), and the result for eutrophication is 0.64 Kg PO 4 equivalent/Ton CPO on the usage of electrical energy, Cummins 1 and Cummins 2. The total impact factor is 2.433 Ton CO2 equivalent/Ton CPO for GWP, 16.41 x 10-3 Ton SO2 equivalent/Ton CPO for acidification, and 2,65 x 10-3 Ton PO4 equivalent/Ton CPO for eutrophication.
Supply Chain Management Performance Measurement. Case Studies from Developing Countries
Authors: Sinoimeri Dea 
Published: June 2023

Supply chain management is critical for companies (suppliers, distributors, manufacturers, and retailers) and researchers. Supply chain sustainability is important in Developing Countries. To evaluate the performance of supply chains in companies located in Developing Countries like Albania and Kosovo, this article will examine the findings of the Supply Chain Operation Reference (SCOR) model. Utilizing the SCOR model can improve a company’s chances of survival and rivalry in the market. The selection of Performance Attributes appears to be the standard for measuring performance. By contrast, Snorm De Boer normalization equates the importance of Key Performance Indicators (KPIs), the Analytical Hierarchy Process (AHP) calculates the weighted criteria of KPIs, and Objective Matrix (OMAX) analyzes the measurement results of the KPIs. This article identifies unexplored areas for future research that will be beneficial in the field of supply chain management, such as the creation of supply chain performance metrics, creation of a model that is tightly integrated into the supply chain, and handling supply chain-related problems and issues.
Long-term Pain Symptomatology in PICU Survivors Aged 8–18 Years
Authors: Holley Amy L. , Battison Eleanor A.J. , Heierle Jessica , Clohessy Denae , Wesemann Dalton , Hall Trevor , Orwoll Ben , Wilson Anna C. , Williams Cydni 
Published: June 2023

BACKGROUND AND OBJECTIVES
Children discharged from the PICU often experience long-term physical, psychological, social and cognitive challenges, described as postintensive care syndrome. This study fills a critical gap by describing the long-term pain symptoms many children experience using child self-report.

METHODS
Participants in this cross-sectional study were children aged 8 to 18 years (and 1 parent, n = 64 dyads) who were 8 to 24 months post-PICU discharge. Participants completed measures assessing pain, psychosocial function, and treatment utilization. Health information relevant to the PICU admission was obtained from the electronic medical record.

RESULTS
Children were an average age of 14.3 years and 50% female. Average pain intensity in the past month was 3.65 (0–10 numeric rating scale), with 36% of children reporting pain ≥2 to 3 days a week. Youth with higher intensity (≥4) and more frequent pain (≥2–3 days a week) had greater pain catastrophizing, pain-related fear, anxiety, and sleep disturbance than those with less frequent and intense pain. Higher pain frequency was also associated with greater pain-related disability and depressive symptoms. Pain was not associated with any PICU-related variables abstracted from the electronic medical record. Parents reported children frequently accessed pain treatment services postdischarge; however, 37.5% reported the coronavirus disease 2019 pandemic impacted access to recommended services.

CONCLUSIONS
A significant portion of children experience pain post-PICU discharge. For many of these children, pain is frequent and is associated with impairments in psychosocial function. Future prospective research studies can be used to identify risk factors of poor pain outcomes so children can receive targeted interventions.
Endoscopic differential diagnosis of the gastritis-like form of primary non-Hodgkin’s lymphomas and neuroendocrine tumors of the stomach
Authors: Lozovaya V. V. , Malikhova O. A. , Tumanyan A. O. , Malikhov A. G. , Gusarova O. A. 
Published: June 2023

Background. The gastritis-like form of primary non-Hodgkin’s lymphomas (NHL) of the stomach is the rarest macroscopic variant of malignant neoplasms of the stomach, endoscopically resembling inflammatory changes in the mucous membrane and, in single observations, polypoid and flatly elevated forms of neuroendocrine tumors (NET) of the stomach. Despite the great experience gained in the diagnosis and treatment of primary NHL of the stomach and NET of the stomach, in clinical practice there are examples that cause difficulties in the correct interpretation of the endoscopic picture and the timely diagnosis.Aims. To analyze the data of a comprehensive endoscopic examination of patients with diagnoses of a gastritis-like form of primary NHL and NET of the stomach, and to identify the main differentially significant endoscopic criteria characteristic of each individual type of neoplasia.Materials and methods. In a prospective study conducted at the FSBI “N.N. Blokhin national medical Research Center of Oncology” of the ministry of Health of Russia in the period from 2017 to 2022, data from endoscopic and morphological studies of 69 patients with gastritis-like malignancies were analyzed. All patients underwent a comprehensive endoscopic examination of the upper gastrointestinal tract – esophagogastroduodenoscopy using all clarifying examination methods (narrow-spectrum mode, examination in magnification mode, a combination of narrow-spectrum examination with magnification mode), accompanied by the taking of biopsy material for the purpose of morphological verification of the diagnosis, and endosonographic study.Results. According to the results of a morphological study, the diagnosis of primary NHL of the stomach was confirmed in 38 patients (55.1 %), NET of the stomach – in 31 patients (44.9 %). A change in diagnosis based on the results of a morphological study occurred in 3 (4.3 %) of 69 (100 %) patients. The sensitivity and diagnostic accuracy of complex endoscopic examination were higher compared to endoscopic examination in white light mode, and amounted to 92.11, 95.65 and 13.16 %, 52.17 %, respectively.Conclusion. for a correct assessment of the endoscopic picture, it is necessary to conduct a comprehensive endoscopic examination using all clarifying diagnostic methods, which shows greater sensitivity and specificity compared to examination in white light mode.
“Essa Cidade Também é Minha”: o graffiti como manifestação da psique de sujeitos urbanos excluídos
Authors: Echegaray Luciana 
Published: June 2023

Resumo: O artigo tem por objetivo demonstrar que o modo como a cidade é planejada influencia na formação de subjetividade humana. Este trabalho tematiza, por meio dos métodos de revisão bibliográfica, depoimentos e registro fotográfico, questões relacionadas à ocorrência do graffiti no espaço urbano como forma de insurgência e de protesto ao modelo de urbanismo hegemônico e excludente, vigente principalmente nas grandes cidades. Neste cenário emergem os grafiteiros, grupo que procura redefinir a paisagem urbana através de intervenções estéticas, funcionais e visuais, em sua busca por pertencer ao lugar, ao mesmo tempo em que denunciam sua exclusão desse espaço. A narrativa foi construída através de abordagem hipotético-dedutiva, com caráter exploratório, descritivo, explicativo e qualitativo. Como decorrência, conclui-se que o graffiti acaba também por revelar a psique e as subjetividades dos sujeitos produtores desta expressão simbólica e material.
(Pesquisa aprovada pelo CEP/UFRGS/ Comitê de Ética em Pesquisa da UFRGS, inscrita no CAAE sob número 16292919.6.0000.5347, parecer final de aprovação número 3.480.294).
Palavras-chave: Graffiti; Insurgência; Exclusão Socioespacial; Invisibilidade; Psique.
Eye Movement Desensitization and Reprocessing Therapy in Chronic Fatigue Syndrome: A Single-Case Experiment Testing the Effect on Persistent Negative Evaluation of Fatigue
Authors: Bouman Sacha , Müller Fabiola , Onghena Patrick , Knoop Hans 
Published: June 2023

Background:While cognitive behavioral therapy (CBT) for chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) can lead to the normalization of fatigue levels and resumption of activities, a subgroup of patients still evaluates fatigue negatively.Objective:The objective was to investigate whether eye movement desensitization and reprocessing (EMDR) therapy leads to a less negative evaluation of fatigue.Method:This was a randomized single-case experimental study. Five CFS/ME patients (all female, mean age of 35 years), who had completed CBT but still evaluated fatigue negatively, received EMDR therapy. The primary outcome, that is, negative evaluation of fatigue, was assessed daily (three items, e.g., “My fatigue is frustrating”). During EMDR therapy sessions, distress in response to a selected image was measured. Clinical assessments were performed before, directly after, and one month after EMDR therapy.Results:During EMDR therapy sessions, all patients reported high distress related to memories of having CFS/ME. EMDR therapy led to a reduction in this distress. Daily measured negative evaluations of fatigue declined in three patients, albeit not significantly. Three of five patients showed clinically relevant improvement in evaluations of fatigue on clinical pre-/post measures.Conclusion:EMDR therapy can reduce emotional distress associated with fatigue, but it is unclear whether it can change its negative evaluation.
Authors: Arsil Poppy , Hidayat Hety Handayani , Wijayanti Riski Febri 
Published: June 2023

The halal product guarantee system, also referred to as SJPH, is an integrated system that was created, implemented and used to control products, production processes, raw materials, and procedures. The objecytve of this study is to identify and design the main criteria of the SJPH. By using qualitatif descriptive exploratory method, a semi-structured questions, was used to interview the key informant. They consist of the leader, vendor and staff of canteen using convenience sample method . A total of 15 key informants were interviewed. Data analysis used a thematic approach. The findings demonstrated that Sudirman Halal Canteen had satisfied the SJPH requirements, which included dedication and responsibility, ingredients, a halal production process, a product, and evaluation and monitoring.
Pressure behaviors and isothermal kinetics of magnesiothermic reduction of titanium tetrachloride in a semi-batch reactor
Authors: Wang Wenhao , Wu Fuzhong 
Published: June 2023

Abstract

There is still no consensus on the pressure behaviors, thermal hazard, reaction pathways, and kinetic characteristics of magnesiothermic reduction of TiCl4, and theoretical innovations are required for further research of titanium sponge metallurgy. We determined efficient reaction pathways via chemical reaction stoichiometry methodology and proposed an innovative isothermal kinetic modeling approach for the magnesiothermic reduction of TiCl4. The net chemical reaction rate of the titanium sponge decreased with decreasing feeding rate of TiCl4 and with increasing gauge pressure, to relieve its rapid pressurization and thermal runaway. The reaction order and activation energy were α = 1.30 and Ea=60.85 ± 4.58 kJ·mol-1 at temperature range of 1053.0 K to 1073.0 K, respectively. And reaction order and activation energy were α = 1.50 and Ea=56.46 ± 1.31 kJ·mol-1 at temperature range of 1073.0 K to 1123.0 K, respectively. The self-heating of magnesiothermic reduction of TiCl4 causes its self-acceleration. And the autocatalytic effect of the sponge structure of the new-formed may play an irreplaceable role.