bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shelf-life of uranium oxide microparticle reference materials and possible implications for the identification of optimal storage conditions
Authors: Hammerich Simon , Potts Shannon Kimberly , Kegler Philip , Neumeier Stefan , Schmitt Axel K. , Trieloff Mario 
Published: January 2023

AbstractDuring their inspections of nuclear facilities, inspectors of the International Atomic Energy Agency (IAEA) collect environmental swipe samples containing uranium dust particles. As reference materials, well-characterized uranium microparticles are required that are suitable for quality control, analytical refinement and method development tasks. At Forschungszentrum Jülich (FZJ), uranium oxide reference microparticles are produced using an aerosol-based process. A core requirement for distribution of a potential reference material is to guarantee a practical shelf-life. Previous studies of structure and shape of uranium oxide microparticles demonstrated possible alteration leading to the formation of uranium hydroxides such as schoepite. A systematic shelf-life study exploring storage under different environmental conditions was launched in late 2021. Uranium microparticles were stored in three environments simulating potential long-term storage conditions, whereas a fourth experiment used an unrealistically harsh environment to assess the effects of accelerated alteration. At the time of writing, only the uranium microparticles intentionally stored under these extreme conditions have shown significant signs of alteration. This implies that synthetic uranium oxide microparticles under common storage conditions have minimal shelf-lives of at least 1 year, and likely much longer.
Graphical abstract
Sequías en Mendoza (Argentina): una mirada sociohistórica desde la segunda mitad del siglo XIX
Authors: Rojas Facundo , Sironi Osvaldo , Martín Facundo 
Published: January 2023

Este trabajo analiza los procesos de escasez hídrica que impactaron en los territorios de la provincia de Mendoza (Argentina) durante la segunda mitad del siglo XIX hasta finales del XX. Desde una perspectiva histórica–ambiental se analizan estos hitos hidroclimáticos desde la visión de diversos actores sociales del territorio provincial en base a los datos obtenidos en fuentes documentales.
A Nautical Instrument Lying of the Plane in Teaching the Concepts of Chord and Arc of Circumference
Authors: Oliveira Francisco Wagner Soares , Pereira Ana Carolina Costa 
Published: January 2023

Background: This work follows in the direction of research dedicated to articulating historical instruments to teach mathematics. Objectives: To analyse the use of the instrument to ﬁnd the altitude of the Sun as a didactic resource for teaching and learning the concepts of chord and arc of a circle in the education of undergraduate students in mathematics. Design: The research takes place through a university extension course that uses the theoretical and methodological foundations of the teaching guidance activity. Setting and Participants: The research environment is the training of students at the State University of Ceará. The training action was attended by 12 participants. The choice criterion was that they were studying for a degree in mathematics, and the selection took place in the order of enrollment in the activity. Data collection and analysis: From the assumptions of the teaching guidance activity, data collection was carried out with the recording of videos and audio, photographic records and students’ writings, while the analysis was based on connections and interconnections on the action of the subjects, and on the conceptual nexuses. Results: The new instrument to ﬁnd the altitude of the Sun has didactic potential to work with the concepts of arc and chord of circumference because, from it, these concepts are mobilised as practice, and it is possible to see how they relate. Conclusions: The new instrument to ﬁnd the altitude of the Sun can be explored in the interface between history and mathematics teaching as a resource to favour teaching and learning, whether in basic education or higher education.
A Gestão Estratégica dos Gastos mediante a utilização do Método de Custos Conjuntos para Faculdades
Authors: Teixeira Ivandi Silva , Teixeira Regina Cleide Figueiredo da Silva , Vasconcellos Ana Maria de Albuquerque 
Published: January 2023

Este estudo teve como objetivo norteador a construção de um modelo de centro de custos conjuntos idealizado para compor a gestão estratégica dos fatores de produção para cada curso de uma Instituição de Ensino Superior da Região Metropolitana de Belém do Estado do Pará. Foi realizado um mapeamentos dos diversos processos acadêmicos e administrativos fundamentais para a compreensão da interrelação entre os setores e analisando as restrições que impactavam ao procedimento de construção de um modelo de centro de custos conjuntos, com a finalidade de viabilizar uma mudança na situação da IES, de modo a fortalecer o processo decisório dos coordenadores de curso, do diretor acadêmico e do diretor geral da IES e mantenedores, com relação ao custo conjunto dos cursos e sua relação na formação do custos totais da instituição. O referencial teórico que sustentou o estudo discorre sobre a eficácia dos processos referentes às atividades do Ensino por curso da IES. O estudo utiliza uma metodologia de natureza exploratória compatível com a apuração dos custos conjuntos das atividades de ensino, sem, no entanto, se reportando às atividades agregadas após o ponto de separação. Os resultados foram obtidos mediante a alocação de recursos financeiros estruturados como custos conjuntos, chamando atenção para os custos comuns na forma como estes afetam a formação do preço por curso. Em sua conclusão, o modelo de custos conjuntos é apresentado de forma objetiva, contemplando os interesses de uma gestão estratégica voltada para a obtenção de melhores resultados em seus cursos de Graduação.
The Effect of COVID-19 on Long-Term Cardiac Function in Patients With Chronic Heart Failure
Authors: Ageev A. A. , Kozhevnikova M. V. , Emelyanov A. V. , Krivova A. V. , Shumskaya Yu. F. , Musaeva L. M. , Popova L. V. , Naymann Yu. I. , Abdullaeva G. B. , Privalova E. V. , Belenkov Yu. N. 
Published: January 2023

Aim To evaluate functional changes in the heart in the long-term following COVID-19 in patients with chronic heart failure (CHF).Material and methods Case reports of 54 patients aged 69.1±9.7 years who had COVID-19 from January 2021 through January 2022 and had been previously diagnosed with NYHA functional class II-III CHF were studied. Two comparison groups were isolated: HF with LV EF >50 % (n=39) and <50 % (n=15). Echocardiography was used to evaluate changes in LV EF and pulmonary artery systolic pressure (PASP) 5-6 months following COVID-19.Results In all CHF patients after COVID-19 at 5.8 months on average, LV EF decreased (median difference, 2.5 %; 95 % confidence interval (CI): 6.99×10–5– 4.99) and PASP increased (median difference, 8 mm Hg; 95 % CI: 4.5–12.9). In the HF group with LV EF <50 %, the decrease in EF was greater than in the group with LV EF >50 % (6.9 and 0.7 %, respectively; p=0.037); furthermore, the CHF phenotype did not influence the change in PASP (p=0.4). The one-factor regression analysis showed that the dynamics of LV EF decrease was significantly influenced by the baseline decrease in LV EF, whereas the change in PASP was influenced by the dynamics of LV EF decrease, presence of dyslipidemia, and statin treatment. Furthermore, the multifactorial analysis showed that prognostically significant factors for long-term changes in LV EF following COVID-19 were male gender (odds ratio (OR), 5.92; 95 % CI: 1.31–26.75; p=0.014), LV EF at baseline <50 % (OR, 0.88; 95 % CI: 0.8–0.96; p<0.001); changes in PASP depended on the presence of dyslipidemia (OR, 0.08; 95 % CI: 0.01–0.84; p=0.018).Conclusion This study showed that COVID-19 in the long term can influence the course of CHF; in this process, HF patients with EF <50 % have progression of systolic dysfunction and PASP, whereas patients with EF >50 % have an isolated increase in PASP.
Prevalence of Heart Failure in a Megalopolis
Authors: Koltsov A. V. , Tyrenko V. V. , Sarana A. M. , Yazenok A. V. , Kogan E. I. , Chentsov D. V. 
Published: January 2023

Aim To assess the prevalence of heart failure (HF) in St. Petersburg from 2019 through 2021 based on medical reports.Material and methods Medical records of 146 912 patients with HF who were managed in St. Petersburg from 2019 through 2021 were analyzed. Prevalence of HF was assessed using a standard ICD-10 I 50.x code for this disease. Also, expanded HF coding was used with ICD-10 codes I09.9, I11.0, I13.0, I13.2, I25.5, I42.0, I42.9, I43.0, I43.1, I43.8, I42.5, I42.7, and I42.8. An additional analysis was performed for mortality from cardiovascular diseases (CVD) as a whole and from HF in particular (n=192 133).Results From 2019 through 2021, the number of both male and female patients with HF increased by 18.14 %. The greatest number of HF patients was in the age group of 75–89 years in 2019–2020 and 60–74 years in 2021, with females prevailing. The HF incidence increased in the age group of 45–59 years with a peak morbidity at age of 60-74 for men and 75-89 for women, which was consistent with the life expectancy of each gender. The expanded coding allowed a more complete presentation of HF prevalence and also to take into account patients with HF caused not only by myocardial infarction or acute cardiac pathology but also by rheumatic heart disease, arterial hypertension, myocarditis, and cardiomyopathies. Cardiovascular mortality significantly increased by 20.1% during the period from 2019 through 2021. The HF prevalence for deceased patients also was steadily increasing during 3 years. Analysis of associated pathology in HF patients revealed, in most cases, hypertension, ischemic heart disease, cerebrovascular diseases, diabetes mellitus, and obesity.Conclusion The increase in HF prevalence and mortality draws attention and calls for managing measures to change the current situation in health care. A registry is required to characterize a typical patient with HF and to present an unbiased picture of HF prevalence. It is also necessary to develop programs for outpatient follow-up of patients in this category and for providing current, highly effective medicines. Education of patients and improving the knowledge of therapists in diagnosis and treatment of HF are most relevant for enhancing the quality and duration of patients’ life and for reducing the number of hospitalizations and the HF mortality.
Kekuatan Pembuktian Sertifikat Hak Atas Tanah Sebagai Bukti Kepemilikan Objek Pengadaan Tanah Bagi Pembangunan Untuk Kepentingan Umum
Authors: Rohmati Ulfa 
Published: January 2023

ABSTRACT: Inconsistency between Article 41 paragraph (3) of Law Number 2 of 2012 concerning Land Procurement for Development in the Public Interest and Article 19 paragraph (2) letter c of Law Number 5 of 1960 concerning Basic Regulations on Agrarian Principles in conjunction with Article 32 of Regulation Government Number 24 of 1997 concerning Land Registration. Article 19 paragraph (2) letter c of the UUPA in conjunction with Article 32 of PP Number 24 of 1997 which states that the certificate is valid as a strong evidence. Meanwhile, Article 41 paragraph (3) of Law Number 2 of 2012 explains that the certificate is valid as a means of absolute proof and cannot be contested in the future. The sentence “inviolability in the future raises the perception that Article 41 will give birth to injustice for third parties if he is the rightful owner of the plot of land that is used as the object of land acquisition. This study aims to determine the suitability of the law on land acquisition for development in the public interest with the land registration system in Indonesia and the legal consequences if there are parties who object to proof of ownership of land acquisition objects for development in the public interest. The method used in this research is normative juridical using a statutory approach and a conceptual approach. The method of collecting legal materials is through literature study with deductive analysis. From the results of the study, it can be concluded that the law on land acquisition for development in the public interest is not in accordance with the land registration system in Indonesia which causes if there are parties who object to the certificate as proof of ownership of the object of land acquisition, then that party will lose their land rights along with compensation. losses on the implementation of land acquisition if the objecting party can provide other evidence that can weaken the strength of proof of the certificate.
KEYWORDS: certificate, land registration, land acquisition
Differential response of growth and C:N:P stoichiometry to Si supply between bamboo and tree saplings
Authors: Liu Xiaoyu , Tang Xinghao , Compson Zacchaeus G. , Huang Dongmei , Zou Guiwu , Luan Fenggang , Song Qingni , Fang Xiong , Yang Qingpei , Liu Jun 
Published: January 2023

Abstract
Background
Silicon (Si), while not an essential element for plant growth, can be important for high Si-accumulating Poaceae, such as Moso bamboo. However, other trees do not actively take up dissolved silicic acid [Si(OH)4] from the soil, likely because they have fewer or no specific Si transporters in their roots. It is unclear what causes the different growth and nutrient status between bamboo and other trees under varying Si supply.
Results
In this study, we found that Si addition increased the biomass production of P. pubescens saplings, likely by improving its net photosynthetic rate and nutrient status, which contrasted to the saplings of P. bournei and S. superba. In addition, we found that C concentrations of aboveground tissues in P. pubescens declined with increasing Si supply, likely due to a partial substitution of organic C compounds by Si. Si addition increased the foliar C:N stoichiometry in the saplings of P. bournei and S. superba through altering their concentration of C and N, but did not affect the C:N or N:P stoichiometry of C. lanceolata and P. pubescens.
Conclusions
Si elicited either a positive or negative effect on plants, such as improve or weaken photosynthetic capacity, increase or decrease the concentration of C and N in plants, depending much on plant species and the Si supply level of in the environment. These results have implications for assessing the growth and nutrient status between bamboo and trees (i.e, high Si-accumulating plants compared to other plants) when Si availability is altered in ecosystems.
Factors associated with dosimetric changes and value of adaptive radiotherapy in patients undergoing radiotherapy for head and neck cancer
Authors: Bonnet Flore , Créhange Gilles , Berthaut Aurélie , Fouquier Anais , Truc Gilles , Chevalier Cédric , Roukoz Camille , Mirjolet Céline , Bidault Fabienne , Vulquin Noémie , Thibouw David 
Published: January 2023

Abstract
Background: Anatomical changes may occur during radiotherapy (RT) in Head and neck (H&N) cancer patients. These may lead to deviations between the initially planned doses and the delivered doses leading to a risk of organs at risk (OAR) overdose and tumor volume undercoverage. The aim of this study is to identify H&N patients who would benefit from adaptive radiotherapy (ART).
Material and Methods: Retrospective data were collected for patients treated with RT for H&N cancer requiring a new dosimetric computed tomography (CT) during treatment. The initially planned doses to OAR and tumor volumes were compared to the doses actually received with and without ART. Predictive criteria for dose deviations greater than 5% were tested.
Results: Among 51 patients included in this study, 29 had an overdose to at least one OAR and 13 had a tumor volume undercoverage. Brainstem overdose was associated with cervical volume decrease between the initial dosimetric CT and the 36±2Gy cone beam CT (CBCT) (OR= 11.29, p= 0.027). Homolateral parotid gland (PG) overdose was associated with a decrease of cervical volume (OR= 4.5, p= 0.033) as well as the decrease in high-risk clinical and planned target volumes (HR CTV and PTV) between the initial and the new dosimetric CT [(OR= 3.38, p = 0.04) and (OR= 7.5, p= 0.017 respectively)]. Tumor volume undercoverage was associated with an older age at diagnosis (OR= 6.79, p= 0.022), a small initial macroscopic tumor volume (OR= 9.33, p= 0.006), and a decrease in HR CTV and PTV at the new dosimetric CT (OR= 7.29, p= 0.016; and OR= 7.7, p= 0.006 respectively). With ART, 19 patients (37.3%) showed an improvement in the sparing of at least one OAR and 6 (11.8%) an improvement in tumor volume coverage.
Conclusion: Factors such as a decrease in cervical diameters and volume during RT, low initial GTV, high age at diagnosis or a decrease in CTV and PTV HR during RT may help predict possible overdosage to OARs or PTV undercoverage. This might allow a better selection of patients who can benefit from ART.
Accuracy of Invisalign Progress Assessment with clear aligners: a retrospective study
Authors: Li Bo , Xu Yi-Meng , Shi Rui-Ying , Hu Yi-Rong , Liu Si-Ying , Gu Ze-Xu 
Published: January 2023

Abstract
Objective
The objective of this study was to detective the accuracy of model superimposition and automatic analysis for upper and lower dentition width in Invisalign Progress Assessment during the process of clear aligners.
Methods
19 cases were included in this study. Pre-treatment dental cast(T0) and post-treatment dental cast after staged treatment(T1) were available for three-dimensional model superimposition. Subsequently, movements of maxillary teeth in horizontal plane (cross section) after staged treatment, width of upper and lower dentition were measured by three-dimensional model superimposition in real world and Invisalign Progress Assessment separately. Consequently, the data collected from these two methods was compared.
Results
In Invisalign Progress Assessment, movements of maxillary teeth in horizontal plane after staged treatment was 2.31（1.59,3.22） (median (upper quartile, lower quartile)) millimeter (mm), while in three-dimensional model superimposition, the result was 1.79（1.21,3.03）mm. The difference between two groups is significant(P＜0.05). Intercanine width upper, intermolar width upper, intercanine width lower, and intermolar width lower were 36.55±2.76mm, 56.98±2.62mm, 28.16±1.85mm, 53.21±2.72mm separately in Invisalign Progress Assessment and were 36.48±2.78mm, 56.89±2.58mm, 28.05±1.85mm, 53.16±2.64mm separately in three-dimensional model analysis, which were no significant difference among these groups (P＞0.05).
Conclusions
The data from Invisalign Progress Assessment was not in parallel with what achieved from model superimposition with palate as reference completely. The accuracy of model superimposition in Invisalign Progress Assessment needs further investigation, whereas the accuracy of model analysis in Invisalign Progress Assessment was accurate. Thereby, results from Invisalign Progress Assessment should be interpreted with caution by the orthodontist in clinic.
Is it safe to perform Enterectomy in colorectal cancer patients aged 80 or older? A meta-analysis and a systematic review
Authors: Chen Bangquan , Yu W. H. , Ma Y. , Xu P. R. , Qing Y. , Shanu Shantanu , Sun Q.N. , Ren J. , Wang D.R. 
Published: January 2023

Abstract
Background
Colorectal cancer is one of the four most common cancers in the world. At present, Human beings have stepped into an aging society, and the number of over eighties colorectal cancer patients has increased year by year. However, few high-quality studies focused on the post-operation complications and long term outcomes of octogenarian patients with colorectal cancer. This meta-analysis based on published studies aims to assess the safety of treating octogenarian CRC patients with surgery.
Methods
Databases, including PubMed, Embase, and Cochrane Library were searched until July 2022. The incidence of preoperative comorbidities, postoperative complications, and mortality was assessed using odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Furthermore, the hazard ratios (HRs) with 95% CIs were applied for survival outcomes.
Results
A total of 13,790 patients with CRC in 21 studies were included. Our results demonstrated that octogenarian patients were associated with a higher burden of comorbidities (OR = 3.03;95% CI: 2.03, 4.53༛P = .000), high incidences of overall postoperative complications (OR = 1.63༛95% CI༚1.29,2.06༛P = .000), high internal medicine postoperative complications (OR = 2.38༛95% CI༚1.76, 3.21༛P = .000), high in-hospital mortality (OR = 4.01༛95% CI༚3.06, 5.27༛P = .000) and poor overall survival (OR = 2.13༛95% CI༚1.78, 2.55༛P = .000).But there is no statistical difference in surgery-related postoperative complications(OR = 1.16༛95% CI༚0.94, 1.43༛P = .16) and DFS༈OR = 1.03༛95% CI༚0.83, 1.29༛P = .775).
Conclusions
Considering the high burden of comorbidities, high incidences of postoperative complications and mortality, surgery for extremely elderly patients with CRC requires deliberation. Nevertheless, the survival outcomes of octogenarian and even older patients is similar to those of youth patients. Some of them might benefit from conservative treatments or palliative surgeries indeed. Hereby, individualized treatment is recommended for such patients. Instead of actual age, physical age is the real element the clinicians should take into consideration.
Extraction, purification, characterization, and α-amylase inhibition of C- Phycocyanin from Dolichospermum spiroides
Authors: Sanniyasi Elumalai , Jayachandran Sharath , Gopal Rajesh Kanna , Rajesh Damodharan 
Published: January 2023

Abstract
Phycocyanin is a phycobiliprotein pigment synthesized by cyanobacteria to protect the light-harvesting complex from the high intensity of light during photosynthesis. Intriguingly, it has a wide range of biotechnological applications such as pharmaceuticals, cosmeceuticals, and food-grade pigments based on their purity. Phycocyanin is a highly antioxidant water-soluble pigment with anticancer, anti-inflammatory, hepatoprotective, and neuroprotective properties. Phycocyanin from Spirulina (Arthrospira platensis) has been reported to possess antidiabetic activity by inhibiting the α-amylase enzyme both in vitro and in vivo. In our present study, C-phycocyanin was extracted and purified from the cyanobacterium Dolichospermum spiroides with a purity of 1.2, and 3.5 after column chromatographic purification with a molecular weight of 16 kDa. Based on protein mass fingerprinting, it has about 45% amino acid sequence similarity with the C-PC of Aphanizomenon flos-aquae. The C-PC of D. spiroides has a maximum inhibition of 90% at 250 µg/mL of α-amylase enzyme. At the same concentration of the standard drug acarbose, which attained only 80% of α-amylase inhibition. As a result, the IC50 value of C-PC from D. spiroides was 162.16 ± 0.63 µg/mL, and acarbose was 205.86 ± 0.53 µg/mL. Therefore, the alpha-amylase inhibition of phycocyanin was higher than that of the standard drug acarbose. Hence, it is clear that the C-PC of D. spiroides has anti-diabetic activity.