bluuebunny/crossref_metadata_2025_split huggingface dataset:
C2 Dome-Like Expansive Laminoplasty Versus C2 Open-Door Laminoplasty for Treating Multilevel Cervical Ossification of the Posterior Longitudinal Ligament Involving C2
Authors: Zhou Xin , Xia Bo , Chen Fei , Zhu Jingyu , Lu Xuhua , Ni Bin , Guo Qunfeng 
Published: January 2023

BACKGROUND:
There are controversies over the treatment of cervical ossification of the posterior longitudinal ligament (OPLL) involving C2.

OBJECTIVE:
To compare the outcomes of C2 dome-like expansive laminoplasty (C2DL) and C2 open-door laminoplasty (C2OL) for treating cervical OPLL involving C2.

METHODS:
The data of 36 patients undergoing C2OL and 40 patients treated with C2DL because of cervical OPLL involving C2 were retrospectively analyzed. The functional outcomes of the Japanese Orthopedic Association score, Neck Disability Index, 36-Item Short Form Health Survey score, and visual analog scale score for neck pain were compared between the 2 groups. The C2-C7 Cobb angle, cervical range of motion (ROM), and space available for the spinal cord at C2 were measured.

RESULTS:
At the final follow-up, the Japanese Orthopedic Association score, Neck Disability Index, and 36-Item Short Form Health Survey score significantly improved in both groups (all P < .05), but with no significant intergroup differences (all P > .05). The visual analog scale score for neck pain reduced significantly in both groups (P < .05), but the patients in the C2OL group experienced more severe neck axial pain (P < .05). The C2-C7 Cobb angle and cervical ROM reduced greatly in both groups (P < .05), but those in the C2OL group decreased more (P < .05). The spinal cord at C2 significantly improved in both groups (P < .05), with no significant intergroup differences (P > .05).

CONCLUSION:
C2DL was superior to C2OL in maintaining the cervical alignment and ROM and reducing neck axial pain for treating OPLL involving C2.
Variation in Cervical Pedicle Morphology: Important Considerations for Posterior Cervical Procedures
Authors: Goldberg Jacob L. , Carnevale Joseph A. , Xia Jimmy , Sommer Fabian , Gadjradj Pravesh , Medary Branden , Giantini-Larsen Alexandra , Navarro-Ramirez Rodrigo , Tsiouris A. John , Chakravarthy Vikram , Schwarz Justin T. , McGrath Lynn B. , Virk Michael S. , Fu Kai-Ming , Riew K. Daniel , Hussain Ibrahim , Härtl Roger 
Published: January 2023

BACKGROUND:
Safe posterior cervical spine surgery requires in-depth understanding of the surgical anatomy and common variations. The cervical pedicle attachment site to the vertebral body (VB) affects the location of exiting nerve roots and warrants preoperative evaluation. The relative site of attachment of the cervical pedicle has not been previously described.

OBJECTIVE:
To describe the site of the pedicle attachment to the VB in the subaxial cervical spine.

METHODS:
Cervical spine computed tomography scans without any structural, degenerative, or traumatic pathology as read by a board-certified neuroradiologist during 2021 were reviewed. Multiplanar reconstructions were created and cross-registered. The pedicle's attachment to the VB was measured relative to the VB height using a novel calculation system.

RESULTS:
Fifty computed tomography scans met inclusion criteria yielding 600 total pedicles between C3-T1 (100 per level). The average patient age was 26 ± 5.3 years, and 21/50 (42%) were female. 468/600 (78%) pedicles attached in the cranial third of the VB, 132/600 (22%) attached in the middle third, and 0 attached to the caudal third. The highest prevalence of variant anatomy occurred at C3 (36/100 C3 pedicles; 36%).

CONCLUSION:
In the subaxial cervical spine, pedicles frequently attach to the top third of the VB, but significant variation is observed. The rate of variation is highest at C3 and decreases linearly with caudal progression down the subaxial cervical spine to T1. This is the first report investigating this morphological phenomenon.
Single-Center Case Series of Simple Proximal Clipping for Large Thrombosed Vertebral Artery Aneurysms: Preservation of Perforating Arteries and Long-Term Outcomes
Authors: Arai Shintaro , Mizutani Tohru , Sugiyama Tatsuya , Sumi Kenji , Matsumoto Masaki 
Published: January 2023

BACKGROUND:
Surgical proximal parent artery occlusion (PAO) is one of the treatments for partially thrombosed vertebral artery aneurysms (PTVAs). However, whether long-term changes in size and perforating arteries through the blind end can be truly preserved remain unknown.

OBJECTIVE:
To evaluate the efficacy and safety of surgical proximal PAO for PTVAs, focusing on the transition in size and preservation of perforating arteries.

METHODS:
We retrospectively reviewed 14 consecutive cases of unruptured large PTVAs. The cases were treated with surgical proximal PAO without trapping or thrombectomy. Preservation of the perforating arteries was confirmed through intraoperative indocyanine green video angiography. The aneurysm size was evaluated by measuring the maximum diameter on axial T2-weighted magnetic resonance images. Post-treatment outcomes were assessed using the modified Rankin Scale at the last follow-up examination.

RESULTS:
Thirteen patients (excluding 1 with morbidity) had a mean follow-up time of 33.2 months (range, 12-60 months) and a mean reduction rate of 71% (range, 32%-95%). Only 1 patient (7.2%) experienced postoperative stroke, and 13 patients (92.8%) showed no worsening of the modified Rankin Scale score at the final follow-up examination. The symptoms were improved in 5 of the 6 symptomatic patients (83.3%). In 10 patients (71.4%), a perforating branch that could not be identified on preoperative imaging was identified intraoperatively.

CONCLUSION:
Surgical proximal PAO without trapping or thrombectomy for PTVAs allows long-term reduction of aneurysm size and improves treatment safety by preserving the perforating artery, especially in cases wherein direct reconstruction is not feasible.
Magel2 truncation alters select behavioral and physiological outcomes in a rat model of Schaaf-Yang syndrome
Authors: Reznik Derek L. , Yang Mingxiao V. , Albelda de la Haza Pedro , Jain Antrix , Spanjaard Melanie , Theiss Susanne , Schaaf Christian P. , Malovannaya Anna , Strong Theresa V. , Veeraragavan Surabi , Samaco Rodney C. 
Published: January 2023

ABSTRACT
Previous studies in mice have utilized Magel2 gene deletion models to examine the consequences of its absence. We report the generation, molecular validation and phenotypic characterization of a novel rat model with a truncating Magel2 mutation modeling variants associated with Schaaf-Yang syndrome-causing mutations. Within the hypothalamus, a brain region in which human MAGEL2 is paternally expressed, we demonstrated, at the level of transcript and peptide detection, that rat Magel2 exhibits a paternal, parent-of-origin effect. In evaluations of behavioral features across several domains, juvenile Magel2 mutant rats displayed alterations in anxiety-like behavior and sociability measures. Moreover, the analysis of peripheral organ systems detected alterations in body composition, cardiac structure and function, and breathing irregularities in Magel2 mutant rats. Several of these findings are concordant with reported mouse phenotypes, indicating the conservation of MAGEL2 function across rodent species. Our comprehensive analysis revealing impairments across multiple domains demonstrates the tractability of this model system for the study of truncating MAGEL2 mutations.
Behavioral algorithms and neural mechanisms underlying odor-modulated locomotion in insects
Authors: Wechsler Samuel P. , Bhandawat Vikas 
Published: January 2023

ABSTRACT
Odors released from mates and resources such as a host and food are often the first sensory signals that an animal can detect. Changes in locomotion in response to odors are an important mechanism by which animals access resources important to their survival. Odor-modulated changes in locomotion in insects constitute a whole suite of flexible behaviors that allow insects to close in on these resources from long distances and perform local searches to locate and subsequently assess them. Here, we review changes in odor-mediated locomotion across many insect species. We emphasize that changes in locomotion induced by odors are diverse. In particular, the olfactory stimulus is sporadic at long distances and becomes more continuous at short distances. This distance-dependent change in temporal profile produces a corresponding change in an insect's locomotory strategy. We also discuss the neural circuits underlying odor modulation of locomotion.
Scheduling Concurrent Training 48 versus 72 h after Simulated Match Play: Effects on Neuromuscular Function and Fatigue
Authors: CROSS REBECCA , LOVELL RIC , MARSHALL PAUL W. , NORRIS DEAN , SIEGLER JASON C. 
Published: January 2023

ABSTRACT

Introduction
Scheduling concurrent training (CT) during the in-season microcycle in field-based team sport is driven by prematch and postmatch recovery. This study examined the neuromuscular function, fatigue, and soreness responses to CT administered 48 h (match day (MD) + 2) versus 72 h (MD + 3) after match.

Methods
Ten male recreational-level team sport athletes were monitored daily during two 5-d microcycles, which began with a simulated match (Soccer-specific Aerobic Field Test (SAFT90)) and CT performed either 48 or 72 h after match. Maximal voluntary force, quadriceps maximum EMG, voluntary activation, muscle contractile function (evoked twitch responses), muscle soreness, and fatigue were assessed immediately before and after the SAFT90, and every 24 up to 96 h after match. Outcome measures were also assessed immediately after CT. The CT consisted of an intermittent sprint protocol and a lower limb resistance training session separated by 1 h.

Results
Immediately after the SAFT90 in both conditions, maximal voluntary force was below baseline (mean change (Δ), −14.6% ± 10.0%; P = 0.03), recovering 48 h post. Quadriceps contractile function (Δ, −31.5% ± 11.4%; P = 0.003) and voluntary activation (Δ, −8.9 ± 6.2%; P = 0.003) were also hampered after the SAFT90, recovering 24 h post in both conditions. In addition, the SAFT90 elicited elevated levels of fatigue and muscle soreness that recovered 24 h after the SAFT90 before increasing at 72 and 96 h post in the MD + 2 and MD + 3 conditions, respectively.

Conclusions
Recovery of fatigue was only observed at the end of the microcycle when CT was prescribed on MD + 2. Therefore, CT scheduled early (MD + 2) in the microcycle might avoid compromising forthcoming match preparation.
Protocol for the electroencephalography guidance of anesthesia to alleviate geriatric syndromes (ENGAGES-Canada) study: A pragmatic, randomized clinical trial
Authors: Deschamps Alain , Saha Tarit , El-Gabalawy Renée , Jacobsohn Eric , Overbeek Charles , Palermo Jennifer , Robichaud Sophie , Dumont Andrea Alicia , Djaiani George , Carroll Jo , Kavosh Morvarid S. , Tanzola Rob , Schmitt Eva M. , Inouye Sharon K. , Oberhaus Jordan , Mickle Angela , Ben Abdallah Arbi , Avidan Michael S. , Clinical Trials Group Canadian Perioperative Anesthesia 
Published: January 2023

Background: There is some evidence that electroencephalography guidance of general anesthesia can decrease postoperative delirium after non-cardiac surgery. There is limited evidence in this regard for cardiac surgery. A suppressed electroencephalogram pattern, occurring with deep anesthesia, is associated with increased incidence of postoperative delirium (POD) and death. However, it is not yet clear whether this electroencephalographic pattern reflects an underlying vulnerability associated with increased incidence of delirium and mortality, or whether it is a modifiable risk factor for these adverse outcomes. Methods: The Electroencephalography Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES-Canada) is an ongoing pragmatic 1200 patient trial at four Canadian sites. The study compares the effect of two anesthetic management approaches on the incidence of POD after cardiac surgery. One approach is based on current standard anesthetic practice and the other on electroencephalography guidance to reduce POD. In the guided arm, clinicians are encouraged to decrease anesthetic administration, primarily if there is electroencephalogram suppression and secondarily if the EEG index is lower than the manufacturers recommended value (bispectral index (BIS) or WAVcns below 40 or Patient State Index below 25). The aim in the guided group is to administer the minimum concentration of anesthetic considered safe for individual patients. The primary outcome of the study is the incidence of POD, detected using the confusion assessment method or the confusion assessment method for the intensive care unit; coupled with structured delirium chart review. Secondary outcomes include unexpected intraoperative movement, awareness, length of intensive care unit and hospital stay, delirium severity and duration, quality of life, falls, and predictors and outcomes of perioperative distress and dissociation. Discussion: The ENGAGES-Canada trial will help to clarify whether or not using the electroencephalogram to guide anesthetic administration during cardiac surgery decreases the incidence, severity, and duration of POD. Registration: ClinicalTrials.gov (NCT02692300) 26/02/2016
Patient reported outcome measures in childbirth and postpartum maternal quality of life: a protocol for systematic review of measurement properties.
Authors: O'Byrne Laura J. , Maher Gillian M. , Khashan Ali S. , Greene Richard A. , Browne John , McCarthy Fergus P. 
Published: January 2023

Background: Patient centred healthcare is the corner stone to many healthcare strategies. Patient specific health needs should be at the fore of healthcare improvements and quality measurements. Patient reported outcome measures (PROM) that support real world clinical effectiveness assessments are increasingly being used to highlight domains where there is the greatest scope for change. Objectives: This systematic review aims to identify and evaluate existing patient reported assessment measures/tool(s) that can be used in developing a PROM for postpartum women. We will assess and evaluate their measurement properties in a transparent and structured way in accordance with the COSMIN guidelines. Methods: Methodological guidelines for systematic reviews of PROMs have been developed by the COSMIN initiative and will be followed for this systematic review. A systematic literature review will be performed using PubMed, CINAHL and EMBASE from inception to the present day. Two reviewers independently will judge eligibility, conduct data extraction and assess the methodological quality of each study as per COSMIN guidelines. Inclusion criteria: studies should concern PROM with an aim to evaluate measurement properties in the development or the evaluation of a PROM of interest. Included PROM will focus upon postpartum women assessing morbidity and quality of care. All peer reviewed studies with an assessment tool designed for patient completion will be considered. Exclusion criteria; abstract, letters and non-peer reviewed publications. Studies will be graded on measurement properties and quality of evidence as laid out by COSMIN. All studies and characteristics eligible for inclusion will be summarised and a recommendation to the most suitable measurement tool(s) will be given. Discussion: We will provide a comprehensive description of all available patient reported assessment tools available for childbirth and postpartum quality of life and recommend based on COSMIN guidelines the most suitable instrument(s) available for use.
Occupational differences in COVID-19 incidence, severity, and mortality in the United Kingdom: Available data and framework for analyses
Authors: Pearce Neil , Rhodes Sarah , Stocking Katie , Pembrey Lucy , van Veldhoven Karin , Brickley Elizabeth B. , Robertson Steve , Davoren Donna , Nafilyan Vahe , Windsor-Shellard Ben , Fletcher Tony , van Tongeren Martie 
Published: January 2023

There are important differences in the risk of SARS-CoV-2 infection and death depending on occupation. Infections in healthcare workers have received the most attention, and there are clearly increased risks for intensive care unit workers who are caring for COVID-19 patients. However, a number of other occupations may also be at an increased risk, particularly those which involve social care or contact with the public. A large number of data sets are available with the potential to assess occupational risks of COVID-19 incidence, severity, or mortality. We are reviewing these data sets as part of the Partnership for Research in Occupational, Transport, Environmental COVID Transmission (PROTECT) initiative, which is part of the National COVID-19 Core Studies. In this report, we review the data sets available (including the key variables on occupation and potential confounders) for examining occupational differences in SARS-CoV-2 infection and COVID-19 incidence, severity and mortality. We also discuss the possible types of analyses of these data sets and the definitions of (occupational) exposure and outcomes. We conclude that none of these data sets are ideal, and all have various strengths and weaknesses. For example, mortality data suffer from problems of coding of COVID-19 deaths, and the deaths (in England and Wales) that have been referred to the coroner are unavailable. On the other hand, testing data is heavily biased in some periods (particularly the first wave) because some occupations (e.g. healthcare workers) were tested more often than the general population. Random population surveys are, in principle, ideal for estimating population prevalence and incidence, but are also affected by non-response. Thus, any analysis of the risks in a particular occupation or sector (e.g. transport), will require a careful analysis and triangulation of findings across the various available data sets.
The Parallel Drone Scheduling Traveling Salesman Problem with Collective Drones
Authors: Nguyen Minh Anh , Hà Minh Hoàng 
Published: January 2023

In this paper, we study a new variant of the parallel drone scheduling traveling salesman problem that aims to increase the utilization of drones, particularly for heavy item deliveries. The system under consideration adopts a technology that combines multiple drones to form a collective drone (c-drone) capable of transporting heavier items. The innovative concept is expected to add further flexibility in vehicle assignment decisions. An especially difficult challenge to address is the collaboration among drones because it requires temporal synchronization between their delivery tours. To better model the reality, we also consider that drone power consumption is a nonlinear function of both speed and parcel weight. We first develop a two-index mixed integer linear programming (MILP) formulation from which a simple branch and cut is developed to solve small-size instances to optimality. To efficiently handle larger problem instances, we propose a ruin-and-recreate metaheuristic with problem-tailored removal and insertion operators, in which an efficient move evaluation procedure based on the topological sort is designed to deal with the complexity of the synchronization constraints. Computational experiments demonstrate the validity of the developed MILP model and the performance of the proposed metaheuristic. Sensitivity analyses based on the classification and regression tree are performed to investigate the benefits of using c-drones and the important factors affecting the efficiency of the new transportation system. History: This paper has been accepted for the Transportation Science Special Issue on Emerging Topics in Transportation Science and Logistics.
Honey quality from the bee Apis cerana, honey potency produced by coconut and sugar palm saps
Authors: Erwan Erwan , Agussalim Agussalim 
Published: January 2023

Abstract. Erwan, Agussalim. 2022. Honey quality from the bee Apis cerana, honey potency produced by coconut and sugar palm saps. Biodiversitas 23: 5854-5861. One of the big problems when keeping honeybees is the limited sustainable feed, especially in the rainy season. The objectives of this study were to evaluate the honey quality from the bee Apis cerana based on the chemical composition and honey potency produced by the coconut and sugar palm saps. This study using thirty colonies of the bee A. cerana was divided into six treatments consisting of sugar palm sap without sugar palm pollen, coconut sap without sugar palm pollen, coconut sap of 50% + sugar palm sap of 50% without sugar palm pollen, sugar palm sap was added by sugar palm pollen; coconut sap was added by sugar palm pollen; coconut sap of 50% + sugar palm sap of 50% was added by sugar palm pollen. The chemical composition of honey from the A. cerana was moisture (20.76 to 21.80%), reducing sugar (62.78 to 68.37%), sucrose (1.44 to 3.42%), diastase enzyme activity (5.17 to 9.04 DN), hydroxymethylfurfural (2.24 to 5.81 mg/kg), and acidity (26.00 to 36.33 mL NaOH/kg). Honey potency produced by the coconut and sugar palm saps in 100 hectares area produces honey was 1542.857 tons/year and 1150 tons/year, respectively. It can be concluded that the quality of A. cerana honey, produced by the sugar palm and coconut saps, is acceptable by the Indonesian national and international standards. The sugar palm and coconut saps have big potential as bee feed, especially for the bee A. cerana.
Growth of Pteropus alecto bats (Chiroptera: Pteropodidae) in cages
Authors: Ransaleleh Tiltje Andretha , Wahyuni Indyah , Kawatu Martha , Laatung Sylvia , Lambey Lucia , Rembet Unstain NWJ 
Published: January 2023

Abstract. Ransaleleh TA, Wahyuni I, Kawatu M, Laatung S, Lambey L, Rembet UNWJ. 2022. Growth of Pteropus alecto bats (Chiroptera: Pteropodidae) in cages. Biodiversitas 23: 6313-6319. Black Flying Fox (Pteropus alecto), known as Paniki yaki, is widely consumed by the residents of Minahasa, North Sulawesi, Indonesia. It is imported from outside the provinces of Gorontalo, Central Sulawesi, and South Sulawesi. The peak of selling bats in Sulawesi is during Thanksgiving Day and religious holidays such as Easter, Christmas, and New Year. Even though the conservation status of this species, according to the International Union for Conservation of Nature (IUCN), is of Least Concern, this species will one day become extinct due to continuous exploration without control. Conservation or cultivation is one of the efforts to preserve this type of bat. Cultivation will be successful when the growth of this mammal is outside the habitat. Therefore, research has been conducted on breeding this animal in cages using five bats. The bats had been taken from the captivity in Wanea Sub-district, Manado city, 58-533 days old. The fruits given as food are papaya, banana, and mango, and the variables measured were the amount of consumption, body weight gain, and morphometry. Furthermore, the data obtained were tabulated and narrated descriptively. The results showed that consumption of P. alecto 1,2,3,4 and 5 fruits were 110.64, 147.86, 192.61, 249.18, and 331.61 g/day, with body weight gain of 0.50, 0.53, 0.96, 1, 17, 1, and 50 g/day. The morphometric growth of P. alecto 1 was total body length 0.10, forearm 0.06, tibia 0.03, ear 0.01 and wingspan 0.08 mm/day. Sequentially, the morphometric growth of P. alecto 2 was 0.11, 0.07, 0.05, 0.01 and 0.12 mm/day, while P. alecto 3 was 0.29, 0.13, 0.06, 0.03, and 0.89 mm/day. The growth of P. alecto 4 was 0.19, 0.02, 0.02.0.01 and 0.89 mm/day, while P. alecto 5 was 0.20, 0.01, 0.01, 0.01 and 0.85 mm/day. In conclusion, the 1st and 2nd P. alecto were in early bone growth, while the 3rd P. alecto was in bone and meat growth, meanwhile, the 4th and 5th P. alecto were in meat and slow bone growth.