Gastric Floating Drug Delivery Systems: A Promising Carriers for The Delivery of Controlled Release Drugs
Authors: Rashid Iqbal Mohammad 
Published: January 2023

Abstract: Low density systems or adaptively coordinated systems that has enough buoyancy to float on over contents of the stomach for a significant length of time without noticeably decelerating the rate of gastric emptying are known as floating systems. To accomplish stomach retention, the principle process of flotation was specifically examined in this drug delivery system. It is advantageous to construct medications in an oral sustained release gastro-retentive dose form for those that are absorbed in the upper portions of the GIT. The development of dynamically controlled systems depends on the rate at which the stomach empties. The most recent FDDS advancements are strategies to reduce the variability that lengthens the drug delivery system's retention period to more than 12 hours. This paper also contains an overview of several contemporary in-vitro methods that demonstrate the correct. This review on floating drug delivery systems (FDDS) was written with the intention of gathering the most recent research with a particular focus on the main mechanism of flotation to induce stomach retention. The most recent changes in A detailed discussion of FDDS is provided, covering the physiological and formulation factors impacting stomach retention, design methods for single-unit and multiple-unit floating systems, and their classification and formulation characteristics. The techniques used in vitro, the in vivo tests used to gauge the effectiveness and use

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of floating systems, and the applications of these systems are all summarised in this paper. These systems are helpful for a number of issues that arise during the creation of a pharmaceutical dosage form.