bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemophilia B in Algeria: Realities and therapeutic perspectives
Authors: Nekkal Mohamed Salim , Mesli Naima , Grifi Fatiha , Cherif Nacira , Ouchenane Zohra , Bettayeb Mohamed Said 
Published: July 2023

AbstractIntroductionHaemophilia B is a debilitating hereditary coagulation disorder characterized by prolonged or spontaneous episodes of bleeding caused by a deficiency of endogenous factor IX. In Algeria, even though many studies are being carried out to evaluate the prevalence and management of haemophilia B, there is a paucity of locally published literature that can be used to understand the most recent information on the disease's epidemiology, diagnostic techniques and treatment options.AimsThe aim of this manuscript is to raise awareness among patients and family clinicians about current practices, recent developments and unmet needs related to haemophilia B in Algeria.MethodsA comprehensive literature search was conducted through online scientific databases to review publications regarding haemophilia B in Algeria. Exclusions of the review include case studies, interregional comparisons, abstract‐only papers and studies outside the range of 2012–2022.ResultsThe findings discussed relate to the epidemiology of haemophilia B in Algeria, the clinical diagnostic process, disease symptoms, the benefits of molecular and genetic testing, advancements in prophylactic care, as well as unmet needs hindering the progression of optimal haemophilia B management.ConclusionThese findings are crucial to encourage the maintenance of national registries with updated epidemiological data, facilitate early and timely detection of disease symptoms, improve the provision of diagnostic facilities and enhance the overall treatment landscape for better patient outcomes.
Impact of autologous platelet concentrates on wound area reduction: A meta‐analysis of randomized controlled trials
Authors: Tang Bangli , Huang Zhongkui , Zheng Xuhai 
Published: July 2023

AbstractThis meta‐analysis aimed to evaluate the impact of autologous platelet concentrates (APCs) on wound area reduction based on randomized controlled trials (RCTs). A comprehensive search was conducted in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Web of Science, and the Cochrane Library to identify relevant literature. The primary outcome measure was the percentage of wound area reduction. Secondary outcome measures included wound healing time and the incidence of infection. A total of 14 studies were included in the meta‐analysis. The results showed that the percentage of wound area reduction was significantly greater in the APCs group compared to conventional treatments (standardized mean difference [SMD] 1.98, 95% confidence interval [CI]: 1.27–2.68, p < 0.001). Subgroup analysis revealed that the percentage of wound area reduction varied based on wound location, follow‐up duration, and type of APCs used. The healing time and incidence of infection presented no significant difference between the two groups. The findings suggest that APCs can effectively reduce wound areas when compared to conventional treatments, without increasing the risk of infection. In addition, the effectiveness of APCs in wound area reduction may vary depending on factors such as wound location, type of APCs used, and follow‐up duration.
Attachment as a predictor of dropout in mentalization‐based treatment
Authors: Remeeus Melissa G. A. , Smits Maaike L. , Bal‐Bax Anna M. , Feenstra Dine J. , Luyten Patrick 
Published: July 2023

AbstractObjectivesAlthough treatments of patients with borderline personality disorder (BPD) were historically associated with relatively high dropout rates, dropout rates in contemporary evidence‐based treatments for BPD are typically substantially lower. However, only a few studies have investigated dropout rates in mentalization‐based treatment (MBT), and even fewer have investigated predictors of dropout in this type of treatment. In this study, we investigated dropout rates in two types of MBT (day hospital MBT [MBT‐DH] and intensive outpatient MBT [MBT‐IOP]) using data from a recent multicenter randomized clinical trial. Given the central importance of attachment considerations in MBT, we also investigated the relationship between dropout in these two treatments and attachment dimensions.DesignWithin a multicenter randomized clinical trial, 114 BPD patients were randomized to MBT‐DH (n = 70) or MBT‐IOP (n = 44).MethodsDropout in both types of MBT was investigated using descriptive analyses, and its association with attachment anxiety and attachment avoidance, as measured by the Experiences in Close Relationships questionnaire at baseline, was investigated using regression analyses.ResultsDropout rates were relatively low (10.5% across both types of MBT) and did not significantly differ between groups (11.4% in MBT‐DH, 9.1% in MBT‐IOP). Attachment avoidance and attachment anxiety did not impact dropout, nor did their interaction or the interaction with the type of MBT.ConclusionsLow dropout rates in both types of MBT indicate a high level of engagement of patients in both programmes. Attachment dimensions were not associated with dropout, consistent with the principle that MBT is tailored to each individual's needs. More research is needed, however, to investigate to what extent attachment is a dynamic context‐bound adaptive process rather than a static personality feature.
On blowups of vorticity for the homogeneous Euler equation
Authors: Konopelchenko B. G. , Ortenzi G. 
Published: July 2023

AbstractBlowups of vorticity for the three‐ and two‐dimensional homogeneous Euler equations are studied. Two regimes of approaching a blow‐up point, respectively, with variable or fixed time are analyzed. It is shown that in the n‐dimensional () generic case the blowups of degrees at the variable time regime and of degrees at the fixed time regime may exist. Particular situations when the vorticity blows while the direction of the vorticity vector is concentrated in one or two directions are realizable.
Thermodynamic Model of the Fluid System H2O–CO2–NaCl–CaCl2 at P-T Parameters of the Middle and Lower Crust
Authors: Ivanov M. V. 
Published: July 2023

Abstract
Based on the earlier obtained equations of state for the ternary systems H2O–CO2–CaCl2 and H2O–CO2–NaCl, an equation of state for the four-component fluid system H2O–CO2–NaCl–CaCl2 is derived in terms of the Gibbs excess free energy. A corresponding numerical thermodynamic model is built. The main part of the numerical parameters of the model coincides with the corresponding parameters of the ternary systems. The NaCl–CaCl2 interaction parameter was obtained from the experimental liquidus of the salt mixture. Similar to the thermodynamic models for H2O–CO2–CaCl2 and H2O–CO2–NaCl, the range of applicability of the model is pressure 1–20 kbar and temperature from 500 to 1400°C. The model makes it possible to predict the physicochemical properties of the fluid involved in most processes of deep petrogenesis: the phase state of the system (homogeneous or multiphase fluid, presence or absence of solid salts), chemical activities of the components, densities of the fluid phases, and concentrations of the components in the coexisting phases. The model was used for a detailed study of the phase state and activity of water on the H2O–CO2–salt sections when changing the ratio $${{{{x}_{{{\text{NaCl}}}}}} \mathord{\left/ {\vphantom {{{{x}_{{{\text{NaCl}}}}}} {({{x}_{{{\text{NaCl}}}}} + {{x}_{{{\text{CaC}}{{{\text{l}}}_{{\text{2}}}}}}})}}} \right. \kern-0em} {({{x}_{{{\text{NaCl}}}}} + {{x}_{{{\text{CaC}}{{{\text{l}}}_{{\text{2}}}}}}})}}$$ from 1 to 0. Changes in the composition and density of coexisting fluid phases at a constant activity of water and changes in the total composition of the system are studied. A set of phase diagrams on sections H2O–NaCl–CaCl2 for different mole fractions of CO2 is obtained. Pressure dependencies of the maximal activity of water in the field of coexisting unmixable fluid phases are obtained for several salt compositions of the system. Due to removal of restrictions resulting from a smaller number of components in ternary systems, the thermodynamic behavior of systems with a mixed composition of the salt significantly differs from the behavior of those with a single salt component.
Educational inequalities in mortality and their mediators among generations across four decades: nationwide, population based, prospective cohort study based on the ChinaHEART project
Authors: Lu Jiapeng , Wu Chaoqun , Zhang Xiaoyan , Yang Yang , Cui Jianlan , Xu Wei , Song Lijuan , Yang Hao , He Wenyan , Zhang Yan , Li Jing , Li Xi 
Published: July 2023

Abstract

Objectives
To assess the different educational inequalities in mortality among generations born between 1940 and 1979 in China, and to investigate the role of socioeconomic, behavioural, and metabolic factors as potential contributors to the reduction of educational inequalities.

Design
Nationwide, population based, prospective cohort study.

Setting
The ChinaHEART (China Health Evaluation And risk Reduction through nationwide Teamwork) project in all 31 provinces in the mainland of China.

Participants
1 283 774 residents aged 35-75 years, divided into four separate cohorts born in 1940s, 1950s, 1960s, and 1970s.

Main outcome measures
Relative index of inequality and all cause mortality.

Results
During a median follow-up of 3.5 years (interquartile range 2.1-4.7), 22 552 deaths were recorded. Among the four generations, lower education levels were found to be associated with a higher risk of all cause death: Compared with participants with college level education or above, the hazard ratio for people with primary school education and below was 1.4 (95% confidence interval 1.2 to 1.7) in the 1940s cohort, 1.8 (1.5 to 2.1) in the 1950s cohort, 2.0 (1.7 to 2.4) in the 1960s cohort, and 1.8 (1.4 to 2.4) in the 1970s cohort. Educational relative index of inequality in mortality increased from 2.1 (95% confidence interval 1.9 to 2.3) in the 1940s cohort to 2.6 (2.1 to 3.3) in the 1970s cohort. Overall, the mediation proportions were 37.5% (95% confidence interval 32.6% to 42.8%) for socioeconomic factors, 13.9% (12.0% to 16.0%) for behavioural factors, and 4.7% (3.7% to 5.8%) for metabolic factors. Except for socioeconomic measurements, the mediating effects by behavioural and metabolic factors decreased in younger generations.

Conclusion
Educational inequalities in mortality increased over generations in China. Improving healthy lifestyles and metabolic risk control for less educated people, especially for younger generations, is essential to reduce health inequalities.
Understanding pre-residency abortion training pathways and career choices in the United States: a qualitative study
Authors: Henderson Rebecca , Barreto Valeria , Nyren Molly , Moumne Olivia , Finley Tory , Byun Sharon , Monaco Alexandra , Steinauer Jody 
Published: July 2023

BackgroundMany factors contribute to the decision to provide abortion in the United States. We aim to describe pre-residency experiences and decisions that contribute to choosing a career as an abortion provider in the United States.MethodsWe conducted 60-min semi-structured telephone interviews with 34 current abortion care providers about their career trajectories, decision-making and planning. Interviews were transcribed and coded by three members of the research team using thematic analysis.ResultsA majority of the participants considered (73.5%, n=25) and firmly committed (62.8%, n=22) to providing abortion care prior to entering residency. They described important professional experiences with women’s health and reproductive rights, as well as personal experiences with abortion care, all of which inspired them to seek out abortion training during medical school and residency. Participants also described a dearth of mentors or role models until late in training, especially for family physicians.ConclusionsOur study suggests that the decision to provide abortion care is often made prior to residency training, before or during medical school, so additional support may be needed to promote exposure to abortion care during undergraduate medical education or even before. Further, there is a need for improved mentorship and role modelling during these periods, especially for family physicians. This may be especially critical after the overturn of Roe v Wade, as medical schools in restrictive states may not be able to provide abortions to patients, depriving students of role models who are abortion providers.
LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W. 
Published: July 2023

Despite recent therapeutic advances, the 5-year survival rate for adults with acute myeloid leukemia (AML) is poor and standard-of-care chemotherapy is associated with significant toxicity, highlighting the need for new therapeutic approaches. Recent work from our group and others established that the G protein-coupled estrogen receptor (GPER) is tumor suppressive in melanoma and other solid tumors. We performed a preliminary screen of human cancer cell lines from multiple malignancies and found that LNS8801, a synthetic pharmacologic agonist of GPER currently in early phase clinical trials, promoted apoptosis in human AML cells. Using human AML cell lines and primary cells, we show that LNS8801 inhibits human AML in preclinical in vitro models, while not affecting normal mononuclear cells. Although GPER is broadly expressed in normal and malignant myeloid cells, this cancer-specific LNS8801-induced inhibition appeared to be independent of GPER signaling. LNS8801 induced AML cell death primarily through a caspase-dependent apoptosis pathway. This was independent of secreted classical death receptor ligands, and instead required induction of reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress response pathways including IRE1α. These studies demonstrate a novel activity of LNS8801 in AML cells and show that targeting ER stress with LNS8801 may be a useful therapeutic approach for AML.

Significance:
Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and ER activation.
Assessing Communicative Resilience in Suicide Prevention for LGBTQ+ Communities: A Qualitative Analysis of Community Conversations
Authors: Agrawal Kelli R. , Bohn Joe , Mathre Kristin , Buzzanell Patrice M. , O’Connell Alexandria , Salinas-Miranda Abraham 
Published: July 2023

Purpose Since LGBTQ + communities experience disproportionate rates of suicidality; it is important to identify strategies for suicide prevention. Research shows that supportive interpersonal communication and identity affirmation helps prevent suicide. The purpose of this analysis is to explore the role of communicative resilience in suicide prevention among LGBTQ + communities. Approach This analysis is part of a community-based participatory research project. Setting In November 2021, a Community-Academic Partnership hosted a virtual town hall, via Zoom, immediately followed by five Community Conversation (CC) groups. Participants Participants were aged 18 years or older and identified as an LGBTQ + community member or active ally. We define active ally as an individual who, through their personal relationships, service to the community, or professional work, actively advocates for and supports members of LGBTQ + communities. Method CC groups were audio-recorded and transcribed (n= 25 participants). Transcripts were inductively coded for thematic analysis and identified themes were deductively coded using Communication Theory of Resilience (CTR) to identify observations of communicative resilience (MaxQDA2020). Results Themes aligned with CTR, including importance of peer and professional support, affirming identities, reducing stigma, cultivating hope, and advocating for equitable policies. Conclusion Findings demonstrate that through communication, members of LGBTQ + communities enact processes of resilience that support and promote suicide prevention. These findings support community mobilization, communicative resilience, and advocacy to help save lives.
Educational intervention improves knowledge and adherence to treatment amongst puerperal women with syphilis: randomized clinical trial
Authors: Lima Maira GR , Bahia Julyana C , Oliveira Flávia S , Vieira Flaviana VM , Cavalcante Agueda Maria RZ , Matos Marcos André , Guimarães Janaína V 
Published: July 2023

Background Gestational syphilis requires early detection and proper treatment to prevent negative maternal-fetal outcomes. This study aimed to evaluate the effectiveness of an educational intervention on treatment adherence and knowledge about syphilis in postpartum women with positive Treponema pallidum results. Methods A randomized, parallel, and open clinical trial was conducted with 64 postpartum women who tested positive for T. pallidum, assigned to two groups (1:1 ratio). The Intervention Group (IG) received an educational intervention on syphilis, including an explanatory leaflet and hands-on demonstrations, along with standard guidelines. The Control Group (CG) received standard guidelines alone. Pre-test and post-test assessments were conducted to measure knowledge and treatment adherence. Statistical analyses included descriptive and inferential methods, assessing group homogeneity using the Chi-square or Fishers exact test. The interventions effectiveness was determined using relative risk, and pre- and post-test scores were compared using the independent t test. Results The post-test revealed improvements in knowledge scores for general knowledge, treatment, and prevention domains ( p < .05). The IG demonstrated an increase in post-test knowledge scores ( p = .001), with association between post-test scores and treatment adherence ( p = .001). Conclusion The educational intervention on syphilis improved knowledge and treatment adherence in postpartum women with syphilis.
Predictors of British Isles Lupus Assessment Group-based outcomes in patients with systemic lupus erythematosus: Analysis from the Systemic Lupus International Collaborating Clinics Inception Cohort
Authors: David Trixy , Su Li , Cheng Yafeng , Gordon Caroline , Parker Benjamin , Isenberg David , Reynolds John A , Bruce Ian N ,   on behalf of The Systemic Lupus International Collaborating Clinics Consortium,   MASTERPLANS Consortium
Published: July 2023

Background We aimed to identify factors associated with a significant reduction in SLE disease activity over 12 months assessed by the BILAG Index. Methods In an international SLE cohort, we studied patients from their ‘inception enrolment’ visit. We also defined an ‘active disease’ cohort of patients who had active disease similar to that needed for enrolment into clinical trials. Outcomes at 12 months were; Major Clinical Response (MCR: reduction to classic BILAG C in all domains, steroid dose of ≤7.5 mg and SLEDAI ≤ 4) and ‘Improvement’ (reduction to ≤1B score in previously active organs; no new BILAG A/B; stable or reduced steroid dose; no increase in SLEDAI). Univariate and multivariate logistic regression with Least Absolute Shrinkage and Selection Operator (LASSO) and cross-validation in randomly split samples were used to build prediction models. Results ‘Inception enrolment’ ( n = 1492) and ‘active disease’ ( n = 924) patients were studied. Models for MCR performed well (ROC AUC = .777 and .732 in the inception enrolment and active disease cohorts, respectively). Models for Improvement performed poorly (ROC AUC = .574 in the active disease cohort). MCR in both cohorts was associated with anti-malarial use and inversely associated with active disease at baseline (BILAG or SLEDAI) scores, BILAG haematological A/B scores, higher steroid dose and immunosuppressive use. Conclusion Baseline predictors of response in SLE can help identify patients in clinic who are less likely to respond to standard therapy. They are also important as stratification factors when designing clinical trials in order to better standardize overall usual care response rates.
Participation in the national cervical screening programme among women from New South Wales, Australia, by place of birth and time since immigration: A data linkage analysis using the 45 and up study
Authors: Yuill Susan , Egger Sam , Smith Megan A , Velentzis Louiza , Saville Marion , Kliewer Erich V , Bateson Deborah , Canfell Karen 
Published: July 2023

Objective Equitable elimination of cervical cancer in Australia within the next decade will require high National Cervical Screening Program (NCSP) participation by all subgroups of women. The aim of this study was to examine the participation of immigrants compared to Australian-born women. Methods Participation in the NCSP (≥1cytology test) over a 3-year (2010–2012) and 5-year (2008–2012) period, by place of birth and time since immigration was examined using individually linked data of 67,350 New South Wales (NSW) women aged ≥45 enrolled in the 45 and Up Study. Results Three-year cervical screening participation was 77.0% overall. Compared to Australian-born women (77.8%), 3-year participation was lower for women born in New Zealand (adjusted odds ratio 0.77, 95% confidence interval 0.69–0.87), Oceania (0.67, 0.51–0.89), Middle East/North Africa (0.76, 0.60–0.97), South-East Asia (0.72, 0.60–0.87), Chinese Asia (0.82, 0.69–0.97), Japan/South Korea (0.68, 0.50–0.94), and Southern/Central Asia (0.54, 0.43–0.67), but higher for women from Malta (2.85, 1.77–4.58) and South America (1.33, 1.01–1.75). Non-English-speaking-at-home women were less likely to be screened than English-speaking-at-home women (0.85, 0.78–0.93). Participation increased with years lived in Australia but remained lower in immigrant groups compared to Australian-born women, even after ≥20 years living in Australia. Similar results were observed for 5-year participation. Conclusions Women born in New Zealand, Oceania, and parts of Asia and the Middle East had lower NCSP participation, which persisted for ≥20 years post-immigration. The NCSP transition to primary HPV screening, and the introduction of the universal self-collection option in 2022, will offer new opportunities for increasing screening participation for these groups.