bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraparenchymal Meningioma in the Parieto-Occipital Region: A Case Report of a Diagnostically Challenging Tumor
Authors: Khojah Osama , Aljohani Sara , Aldahlawi Abdulaziz , Samkari Alaa , Alzahrani Moajeb Turki 
Published: January 2023

Abstract
Background: Intraparenchymal meningioma is a rare entity of one of the most common brain tumors. It is challenging to diagnose preoperatively due to the vague clinical presentation and absence of stereotypical radiological features. These atypical features might mislead the differential to favor high-grade gliomas or brain metastasis.
Case presentation: We describe a case of a 46-year-old male who presented with vertigo, right-sided sensorineural hearing loss, and bilateral blurred vision. Contrast-enhanced magnetic resonance imaging (MRI) of the brain revealed a large parieto-occipital contrast-enhanced mass with a multi-loculated cystic component and diffusion restriction but without dural attachment. A gross total reaction was achieved, and the histopathological results yielded a WHO grade I meningioma diagnosis. The patient exhibited no signs of recurrence after two years of follow-up.
Conclusion: Intraparenchymal meningiomas are difficult to identify without histopathological assessment. We emphasize the importance of considering this diagnosis when outlining an initial differential as it may direct management planning. Total surgical resection is the best treatment modality for such cases; however, radiotherapy is a valuable option. The prognosis of intraparenchymal meningiomas is generally favorable.
Multiplex PCR assay for identifying five species of chigger mites in the Republic of Korea
Authors: Lee Hyeon Seung , Choi Kwang Shik 
Published: January 2023

Abstract
Background
Molecular date of chigger mites, disease vectors of scrub typhus, are lacking; therefore, they are typically identified morphologically. However, owing to the small size of chigger mites, they are easily damaged. Moreover, factors such as spontaneous mutation and the morphological similarity of adults make accurate classification and identification difficult. Therefore, this study aimed to develop a rapid and accurate molecular method for identifying five chigger mite species (Leptotrombidium pallidum, L. palpale, L. scutellare, L. orientale, and Euschoengastia koreaensis) that transmit scrub typhus in the Republic of Korea.
Methods
Species-specific primers for multiplex polymerase chain reaction (PCR) were designed using the internal transcribed spacer regions of 106 chigger mite samples from five species.
Results
Pieces of multiplex PCR products with unique size were created as follows: L. palpale, 933 bp; L. orientale, 747 bp; L. pallidum, 567 bp; E. koreaensis, 487 bp; L. scutellare, 244 bp).
Conclusions
A multiplex PCR-based molecular method was successfully developed for identifying five chigger mite species (mainly collected from rodents) that transmit scrub typhus in Korea and are distribute nationwide. This multiplex PCR assay will complement morphological classification, providing an accurate species identification method that will be useful for monitoring chigger mites.
Prognostic value of pretreatment procalcitonin and neutrophil– lymphocyte ratio in extensive-stage small-cell lung cancer
Authors: Chen Dongfang , Xu Jianlin , Zhao Yizhuo , Han Baohui , Zhong Runbo 
Published: January 2023

AbstractPurpose To investigate the influence of pretreatment neutrophil-to-lymphocyte ratio (NLR) and procalcitonin (PCT) on progression-free survival (PFS) in extensive-stage small-cell lung cancer (SCLC) patients. Methods A total of 100 extensive-stage SCLC patients were enrolled in our study. Patients were stratified according to the median values of pretreatment NLR and PCT levels: low NLR group (NLR ≤ 3.17), high NLR group (NLR༞3.17), low PCT group (PCT ≤ 0.06; ng/ml), high PCT group (PCT༞0.06; ng/ml). The Kaplan-Meier method and multivariable Cox regression model were used to reveal the prognostic effects of pretreatment NLR and PCT on PFS. Results The median PFS of the total extensive-stage SCLC patients was 6.0 months. The median PFS of low pretreatment NLR group (NLR ≤ 3.17) was not significantly different from that of high pretreatment NLR group (6.2 months vs 5.8 months; P = 0.675). Patients with low pretreatment PCT (PCT ≤ 0.06; ng/ml) had significantly better PFS than patients with high pretreatment PCT (PCT༞0.06; ng/ml) (6.9 months vs 5.7 months; P = 0.043). With the multivariable Cox regression analysis, the response to first-line chemotherapy (P ≤ 0.001) and pretreatment PCT (HR = 0.516; 95%CI 0.326–0.817; P = 0.005) were identified as independent factors associated with PFS. Conclusion Pretreatment PCT is an independent factor associated with PFS in extensive-stage SCLC patients treated with first-line chemotherapy, but pretreatment NLR reflects no significant prognostic value in our study.
Rational curves in a quadric threefold via an SL(2, C)-representation
Authors: Chung Kiryong , Huh Sukmoon , Yoo Sang-Bum 
Published: January 2023

Abstract

In this paper, we regard the smooth quadric threefold Q3 as Lagrangian Grassmannian and search for fixed rational curves of low degree in Q3 with respect to a torus action, which is the maximal subgroup of the special linear group SL(2, C). Most of them are confirmations of very well-known facts. If the degree of a rational curve is 3, it is confirmed using the Lagrangian’s geometric properties that the moduli space of twisted cubic curves in Q3 has a specific projective bundle structure. From this, we can immediately obtain the cohomology ring of the moduli space.
MSC Classification: 14E05 , 14E15 , 14M15
TCA Cycle Difference is Greatly Related to the Resistance of Bacillus thuringiensis against UV Stress
Authors: Du Xi , Zhang Yile , Wu Haonan , Tan Weilong , Huang Enjiong , Guan Xiong , Zhang Lingling 
Published: January 2023

Abstract
Bacillus thuringiensis (Bt) is a popular and environment-friendly biopesticide. However, similar to other microbial pesticides, Bt is limited by ultraviolet (UV) radiation during its application, which greatly reduces its toxicity and persistence. To further know the mechanism of Bt against UV radiation, metabolomic profiles between Bt LLP29 and its UV-resistant mutant LLP29-M19 were compared, analyzed, and annotated in this study, and then a total of 61 metabolites with different abundances were detected. With P < 0.05 as the standard, a total of 12 metabolic pathways were enriched, including the TCA cycle. According to the result of RT-qPCR, the expression levels of the TCA cycle key genes in Bt LL29-M19, such as icd1 citZ, citB, sdhA, sdhB, sdhC, fumA and mdh, were found down-regulated for 85.58%, 37.02%, 70.87%, 85.97%, 76.33%, 83.15%, 87.28%, and 35.77% than those in Bt LLP29. It was consistent with the down-regulation trend of the TCA cycle key enzymes activity in Bt LLP29-M19. Consistently, the enzyme activities of ICDH, SDH, and PDH in LLP29-M19 were detected 86.28%, 43.93%, and 83.03% lower than those in Bt LLP29. It was revealed that the reduced TCA cycle was required for Bt UV radiation resistance, which was also demonstrated by the addition of inhibitors furfural and malonic acid, respectively. Based on the result of RT-qPCR, the gene transcription levels of the main reactive oxygen species (ROS) generation pathways were down-regulated, such as EMP, however, the activity of the main degrading enzymes was up-regulated, which showed the reduction of ROS generation rate was a way for the TCA cycle to regulate the anti-ultraviolet resistance of Bt. All of these provide solid evidence for reprogramming metabolomics to strengthen Bt UV radiation resistance.
Genelleştirilmiş Kuantum Işınlama Protokolü
Authors: KAYA Emir Oğuz 
Published: January 2023

Bu çalışma kapsamında literatürde var olan tek kubit(kuantum bit) ışınlanma/telenakil (quantum teleportation) protokolünün çok kubit sistemlere genellenmesi incelenmiştir. Ardından, birden fazla hedefe telenakil olanakları tartışılarak, buna dair bir protokol önerilmiştir. Geliştirilen teorik çerçeve kapsamında, kubitler üzerinde değişiklik yapan kuantum mantık kapılarının da genellenmesi tartışılmıştır. Söz konusu kuantum mantık kapılarının genel versiyonları oluşturulmuş olup, literatürdeki özel durumlar için çalıştıkları gösterilmiştir. Işınlanmanın çok kubit-çok hedefe genellenmesi sonucu kurulan teorik çerçevede oluşan denklemlerin bir örüntü içerdiği belirlenmiş olup, bu örüntü aracılığı ile karmaşık tensör çarpımları ile tek tek uğraşmaksızın da protokolün gerçekleştirilebileceği bir yol önerilmiştir.
Çalışma kapsamında çok kubit - tek hedef, çok kubit – çok hedef protokollerine yönelik Python bilgisayar programları oluşturulmuştur. Oluşturulan programların, sunulan teorik çerçevenin ön gördüğü sonuçları başarılı bir şekilde ürettiği gözlenmiştir. Bu programlar aracılığı ile, uzun ve hata yapma olasılığı yüksek matematiksel işlemlerin kısa sürede ve hatasız yapılabilmesinin olanağı yaratılmıştır. Oluşturulan program sonuçları aynı zamanda, yukarıda bahsedilen örüntünün varlığını kanıtlamaktadır.
PERSPECTIVES OF TEACHERS ONLINE AND PRACTICAL KNOWLEDGE IN COVID -19 PANDEMIC ERA
Authors: Wahyuni Sri 
Published: January 2023

Exploration of task preparation for teaching learning process TLP on online for educational time by the time remains high agenda for seeking new ways and means to improve the TLP. This is the challenges for the teacher to be presented in the implementation of teacher education programme that is convenient for the learners in TLP, as solution to the challenges in Education System in the era digital. Teachers prepare role of implementation step by step to learn and practice the necessary knowledge skills and attitudes to become teachers’ competence in the education system. Hopefully they are able to channel information to others for digital online. This research based on the covid-19 pandemic Era, that all activieties have done from home ( WFH), teachers must be proactive individually to expand their skill and join mentoring, training and briefing technical also seminar/workshop online for their ability in a pedagogical social, attitude, and professionalism. There are merits and demerits classes conducted via zoom and Google Classroom in TLP. Where as anything can be accomplished in the traditional classroom done electronically, information / material in TLP could be stored via technology but construction of knowledge especially a teacher cannot be replicated online. The aim of the study was examine the online media are applied in TLP for senior high school using zoom and google classroom as a medium, It also explored their beliefs about merits and demerits and investigated their practical knowledge do the teachers use, for meaningfulness of classes conducted via zoom on TLP in Covid -19 pandemic era as opposed to face to face classes. Qualitative data were collated and analyzed using descriptive statistics to . The conclusion were that zoom and google classroom classes were satisfying and convenient for teachers and others perceived them a litle resistance, and for the students 66,7 % like daring and 33,3 % didn’t like daring .
Stigma With Community Discrimination Behavior on Covid-19 Patients in Tuban
Authors: Munir Miftahul , Suhartono  , Fauziansyah Ahmad , Suryani Aprilia 
Published: January 2023

The rapid transmission of the Covid-19 virus, coupled with the circulation of social media information that cannot be verified, will impact stigma in the form of discriminatory behavior in society. This study aimed to determine the relationship between stigma and community discriminatory behavior in patients with COVID-19 at the Permata Bonang RT Perbon Tuban. This study uses a design with a Cross-sectional Study approach. The population used is part of the community in the Permata Bonang RT, with a total of 45 respondents and a sample of 40 using simple random sampling. The dependent variable is stigma, and the independent variable is discriminatory behavior. Data collection using a questionnaire sheet was analyzed using the chi-square test. The results showed that the positive stigma of society was 60% and the negative stigma of society was 40%; as for the results of discriminatory community behavior that occurred, a small number of respondents had discriminatory behavior, namely 32.5%, and some respondents who did not discriminate, namely 67, 5%. So the results obtained in this study show a relationship between stigma and community discriminatory behavior in patients with COVID-19. The results of the chi-square test evidence this; the p-value is <0.05 (p-value = 0.000), so there is a relationship between stigma and discriminatory behavior in society. Based on the results of this study, respondents are advised to keep thinking positively by providing support and motivation for positive patients for Covid-19, increasing proper knowledge about education and information based on facts so that they can be wiser in responding to current conditions.
Keefektifan permainan domino berbasis Android pada materi bilangan bulat
Authors: Efriani Arvin , Putri Agustiany Dumeva , Handayani Sri 
Published: January 2023

Tujuan penelitian ini adalah untuk menghasilkan permainan domino berbasis android pada materi bilangan bulat di kelas VII Mts Islamiyah Trimoharjo yang efektif untuk digunakan. Peneliti ini menggunakan metode pengembangan dengan dua tahapan yaitu tahap preliminary (tahap persiapan dan tahap pendesainan materi) dan tahap formative evaluation (tahap evaluasi dan tahap revisi). Pada tahap expert review dengan ahli media diperoleh hasil akurasi desain dan kualitas teknis yang baik, sedangkan dengan ahli materi diperoleh hasil akurasi konten yang sesuai sehingga permainan domino berbasis android pada materi bilangan dapat dikatakan valid. Kemudian, media diujicobakan kepada 6 siswa untuk memperoleh media yang praktis. Dari hasil ujicoba pada tahap small group diperoleh hasil 91,66 dengan kategori sangat baik yang artinya media dapat dikatakan praktis untuk digunakan. Selanjutnya, media diujicobakan pada tahap field test untuk melihat keefektifan media pembelajaran. Dari hasi rekapitulasi didapat hasil 95,21 dengan kategori sangat baik yang artinya media dapat dikatakan efektif untuk digunakan. Permainan domino berbasis android efektif digunakan dalam pembelajaran bilangan bulat. Oleh karena itu, perlunya mengembangkan media berbasis android untuk mendukung pembelajaran.The online learning method makes it difficult for Accounting students to understand the material containing calculation theory, such as Budgeting. Therefore, in this study, an application called Budgeting in App has been built, which helps improve understanding of budgeting materials and exercises. The stages of this research include problem analysis, needs analysis, design, application development, and application testing. This application contains seven material topics: sales budget, raw material budget, operating expense budget, inventory, accounts receivable budget, cash budget calculation menu, and debt and capital budget. Tests have been carried out to evaluate the application's reliability, consisting of three scenarios: functional system testing, application flow, and the impact of using applications in teaching and learning. The results show that all application features have been running well and are by the concept of budgeting algorithms, and 75% of students strongly agree that this application has been developed well.
Pengembangan worksheets interaktif berbasis web dengan video pada materi pecahan
Authors: Lestari Pradita Diah Ayu , Jusra Hella 
Published: January 2023

Penelitian ini didasari pada isu-isu yang muncul di sekolah dasar seperti banyak dari peserta didik yang belum dapat memahami, membedakan, dan mengoperasikan bilangan-bilangan dari pecahan. Penelitian ini dilaksanakan untuk mengembangkan worksheets interaktif dengan liveworksheets yang dapat membantu pola berpikir peserta didik dalam memahami materi pecahan dan dapat melatih keterampilan peserta didik dalam bidang teknologi. Selain itu, worksheets interaktif ini juga dapat bermanfaat bagi guru untuk melatih kreativitas. Prosedur dalam penelitian ini ialah Research and Development (RD) dengan model ADDIE. Berdasarkan hasil uji kelayakan oleh 2 pakar materi mendapat persentase skor 78,88% dengan kategori layak, uji yang dilakukan oleh 2 pakar media mendapat persentase skor 81,25% dengan kategori sangat layak, dan perolehan tanggapan 28 peserta didik kelas V sebesar 95,61% dengan kategori sangat layak serta rata-rata perolehan nilai peserta didik sebesar 86,74. Dapat disimpulkan worksheets interaktif ini layak untuk digunakan, dapat digunakan dimana pun, dan worksheets interaktif dapat menjadi alternatif Lembar Kerja Peserta Didik (LKPD) dalam bentuk daring. This study is based on issues that arise in elementary schools, such as many children's inability to understand, recognize, and operate numbers and fractions. This study aims to create live worksheets to help students comprehend fractions while teaching them technology skills. In addition, these interactive worksheets can also be helpful for teachers to practice creativity. Research and Development (RD) with the ADDIE model was employed in this work. The validation test by two material experts yielded a percentage score of 78.88% on decent criteria. The validation test by two media experts failed a percentage score of 81.25% on every proper criterion. The percentage score of 28 students in class V was 95,6% on excellent standards, with an average score of 86.74. As a result, worksheets are appropriate for usage, may be utilized anywhere, and can be used as a substitute for the Student Worksheet in the online form.
Pengembangan media augmented reality sistem tata surya (solar system) pada anak usia 5–7 tahun
Authors: Zsalsabilla Meivi Naura , Hendriana Benny , Masykuroh Khusniyati 
Published: January 2023

Penelitian ini bertujuan menghasilkan sebuah produk berupa aplikasi augmented reality atau AR tentang sistem tata surya untuk anak usia 5-7 tahun. Karena pada saat ini sumber belajar untuk mengenal sistem tata surya hanya bisa melalui buku bergambar, alat peraga dan berkunjung ke planetarium namun tidak semua bisa dengan mudah mengakses itu semua dengan menggunakan teknologi akan sangat membantu untuk dapat mengenal sistem tata surya. Metode yang digunakan dalam penelitian ini ialah metode penelitian RD (Research and Development) dengan model pengembangan ADDIE yang dibagi menjadi lima tahap yaitu analyze, design, development, implementation, dan evaluation. Media pembelajaran augmented reality sistem tata surya ini telah diverifikasi oleh pakar media dan pakar materi. Ahli media mendapatkan hasil rata-rata 92% kategori sangat valid dan ahli materi hasilrata-rata 92% kategori sangat valid. Selain telah divalidasi oleh para ahli, media pembelajaran ini juga telah diujicobakan kepada guru dan orangtua. Hasil tes guru TK Al Munawwarah adalah 89% dalam kategori sangat valid, dan hasil tes orang tua adalah 81% dikategorikan valid. Dapat disimpulkan bahwa media augmented reality sistem tata surya pada anak usia 5-7 tahun dapat dikategorikan valid dan layak digunakan serta dapat dikembangkan.This study aims to produce an augmented reality application about the solar system for 5-7 years old of early childhood education students as the solar system learning resources could only be accessed by books, props, or by visiting the planetarium. However, not all access could be provided by the media mentioned above to help students learn more about the solar system. The RD (Research and Development) method with Addie was employed in this research. Five steps are used in this research: analyze, design, development, implementation, and evaluation. This augmented reality learning media has been validated by several experts, such as media and material experts. The average result by media experts is 92%, and 92% by material experts. This indicates that the categories are highly reliable. Besides this, learning media has also been tested on teachers and parents. Thus, the test result shows that TK Al Munawwarah teachers 89% and student parents show 81% of test results categorized as valid. From the result, it can be concluded that the Augmented Reality learning media for early childhood students aged 5-7 years could be a valid category, preferred to use by an early childhood student, and can be developed.
Meningkatkan kemampuan pendidik dalam penggunaan teknologi melalui workshop adaptasi teknologi
Authors: Ayuningtyas Tyagita , Aeni Ani Nur , Syahid Aah Ahmad 
Published: January 2023

Penelitian ini dilatarbelakangi oleh kurangnya penggunaan teknologi oleh pendidik dalam pembelajaran di SMPN 2 Ujungjaya. Tujuan penelitian ini untuk meningkatkan kemampuan pendidik dalam penggunaan teknologi melalui workshop adaptasi teknologi. Metode penelitian yang digunakan yakni action research menggunakan pendekatan kualitatif serta model stringer untuk meningkatkan kemampuan pendidik dalam penggunaan teknologi melalui workshop adaptasi teknologi dengan jenis tindakan berupa beberapa tahapan yakni persiapan penelitian dan siklus. Pengumpulan data ini dilaksanakan dengan cara wawancara, observasi dan dokumentasi. Subjek penelitian terdiri dari 15 pendidik di SMPN 2 Ujungjaya. Hasil penelitian menunjukan bahwa kemampuan pendidik dalam menggunakan teknologi dalam pembelajaran masih kurang. Tindakan selanjutnya dalam meningkatkan kemampuan pendidik dalam penggunaan teknologi yakni workshop adaptasi teknologi yang mana di dalamnya membahas mengenai beberapa aplikasi yang digunakan yaitu email, Google Form, Google Classroom serta Quizizz. Dari hasil tindakan berupa workshop adaptasi teknologi tersebut yang dilaksanakan selama empat hari pendidik yakni guru berhasil memahami serta merealisasikan aplikasi–aplikasi tersebut dalam mengelola, memahami serta mengevaluasi penilaian hasil peserta didik saat pembelajaran. This research is motivated by educators' lack of use of technology in learning at SMPN 2 Ujungjaya. This research aims to improve educators' ability to use technology through technology adaptation workshops. The research method used is action research using a qualitative approach and a stringer model to improve the ability of educators to use technology through technology adaptation workshops with the type of action in the form of several stages, namely research preparation and cycles. This data collection was carried out through interviews, observation, and documentation. The research subjects consisted of 15 educators at SMPN 2 Ujungjaya. The results showed that the ability of educators to use technology in learning still needs to be improved. The next step in improving the ability of educators to use technology is a technology adaptation workshop that discusses some of the applications used, namely email, Google forms, Google Classroom and Quizizz. The results of the action in the form of a technology adaptation workshop carried out for four days allowed the teacher to understand and realize these applications in managing, understanding, and evaluating the assessment of student outcomes during learning.