bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of traditional Chinese medicine and PDE5i for diabetic erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials
Authors: Xu Huali , Zhang Xiaolong , Zhu Zhirong , Tang Guiliang 
Published: January 2023

Abstract
Although phosphodiesterase type 5 inhibitors (PDE5i) have a therapeutic effect on diabetic erectile dysfunction, its therapeutic effect is not as good as that of non-diabetic population. In recent years, several randomized controlled trials(RCTs) found that the therapeutic effect of traditional Chinese medicine(TCM) combined with PDE5i on diabetic erectile dysfunction may be better than that of PDE5i alone, and we now conduct a systematic review and meta-analysis of these studies. We searched China national knowledge internet (CNKI), Wanfang database, Pubmed, and Embase database. Mean difference (MD) or pooled odds ratio (OR), as well as their 95% confidence intervals (CIs) were calculated. Risk bias tool was used to evaluate the quality of RCTs included in the meta-analysis. Publication bias was estimated by Begg’s funnel plots and Egger’s test. Results of this systematic review and meta-analysis revealed that the change in the IIEF-5 score of TCM + PDE5i group was significantly higher than that of PDE5i group(MD = 3.6, 95% CI [2.34, 4.86]). The clinical efficacy of TCM + PDE5i group was significantly higher than that of PDE5i group(OR = 2.86, 95% CI [1.83, 4.48]). Furthermore, the sexual satisfaction of TCM + PDE5i group was significantly higher than that of PDE5i group (OR = 3.07, 95% CI[1.63, 5.80]). There was no significant difference of the number of adverse events between TCM + PDE5i group and PDE5i group(OR = 0.93, 95% CI [0.49,1.78]). According to the meta-analysis, compared with using PDE5i alone, the regimen combined TCM plus PDE5i has more advantages in terms of IIEF-5, efficiency, and sexual satisfaction, with no increase in adverse effects for erectile dysfunction in patients with type 2 diabetes mellitus. More strict and larger sample size RCTs are needed to verify the findings of this meta-analysis.
Electron cooling in graphene enhanced by plasmon-hydron resonance
Authors: Yu Xiaoqing , Principi Alessandro , Tielrooij Klaas-Jan , Bonn Mischa , Kavokine Nikita 
Published: January 2023

Abstract
Evidence is accumulating for the crucial role of a solid's free electrons in the dynamics of solid-liquid interfaces. Liquids induce electronic polarization and drive electric currents as they flow; electronic excitations, in turn, participate in hydrodynamic friction. Yet, the underlying solid-liquid interactions have been lacking a direct experimental probe. Here, we study the energy transfer across liquid-graphene interfaces using ultrafast spectroscopy. The graphene electrons are heated up quasi-instantaneously by a visible excitation pulse, and the time evolution of the electronic temperature is then monitored with a terahertz pulse. We observe that water accelerates the cooling of the graphene electrons, whereas other polar liquids leave the cooling dynamics largely unaffected. A quantum theory of solid-liquid heat transfer accounts for the water-specific cooling enhancement through a resonance between the graphene surface plasmon mode and the so-called hydrons -- water charge fluctuations --, particularly the water libration modes, that allows for efficient energy transfer. Our results provide direct experimental evidence of a solid-liquid interaction mediated by collective modes and support the theoretically proposed mechanism for quantum friction. They further reveal a particularly large thermal boundary conductance for the water-graphene interface and suggest strategies for enhancing the thermal conductivity in graphene-based nanostructures.
Small-cell lung cancer tumor microenvironment associated with molecular subtypes and platinum resistance
Authors: Park Charny , Kim Jihyun , Kim Sunshin , Park Seong-Yun , Lee Geon Kook , Lim Kun Young , Kim Jin Young , Hwang Jung-Ah , Yu Namhee , Kang Eun Hye , Hwang Mihwa , Song Bo Ram 
Published: January 2023

Abstract
Although molecular subtypes of small-cell lung cancer (SCLC) have been proposed, their therapeutic implications remain unclear. We dissected SCLC subtypes to delineate the tumor-associated microenvironment (TME) implicated in platinum-drug resistance: ASCL1+ (SCLC-A) subtype to be neuroendocrine type resembled RB1/TP53-mutant non-SCLC; inflammatory (SCLC-I) subtype presented CD8+/PD-L1 + T-cell infiltration and endothelial-to-mesenchymal transition (EndMT); NEUROD1 (SCLC-N) subtype showed neurotransmission process activation; and POU2F3+ (SCLC-P) subtype showed upregulated epithelial-to-mesenchymal transition (EMT). Meanwhile, EndMT population was abundant to platinum-resistant SCLC. To overcome platinum resistance, we interrogated drug candidates from high-throughput screening. Cell cycle inhibitors were no longer susceptible to platinum resistance, as against SCLC-A/N. The bromodomain and extra-terminal (BET) inhibitor JQ1 exhibited sensitivity to EndMT promoted by platinum resistance. BET inhibitors are therefore novel therapeutic candidates for overcoming platinum resistance.
Drivers of Antarctic sea ice advance
Authors: Himmich Kenza , Vancoppenolle Martin , Madec Gurvan , Sallée Jean-Baptiste , Holland Paul , Lebrun Marion 
Published: January 2023

Abstract
Antarctic sea ice is mostly seasonal. While important changes in the sea ice seasonal cycle have been observed in the past decades, the lack of process understanding remains a key challenge to interpret these changes. Here, we address this knowledge gap by exploring the processes driving the ice season onset, termed sea ice advance, using remote sensing and in situ observations. We find that seawater freezing drives sea ice advance in most of the inner seasonal ice zone. By contrast, in an outer band a few degrees wide, advance is due to the import of drifting ice into warmer waters. Yet, everywhere in the seasonal ice zone, we show that the date of advance is strongly related to the heat stored in the summer ocean mixed layer. This heat is largely controlled by the timing of sea ice retreat, explaining why the dates of retreat and advance are tightly linked.
iRGD-modified exosomes encapsulate anti-miR-25-3p for targeted pancreatic cancer therapy
Authors: liu rui , Wang Ning , Zuo Duo , Ji Zhi , Wang Xia , Zhou Yunli , Zhang Run shi , Zhao Tiansuo , Deng Ting , ba yi 
Published: January 2023

Abstract
Background
Pancreatic cancer has a high malignancy and rapid progression. It is very easy to metastasize in clinical cases. In recent years, molecular targeted therapy has made some progress in the treatment of some tumors. In this study, we explored the application of miR-25-3p in targeted therapy of pancreatic cancer to improve the survival time of patients with this treatment in the future.
Methods
qRT‒PCR, scratch healing experiments and transwell experiments were applied in this study. iRGD peptide-modified exosomes carrying anti-miR-25-3p and in situ model mice were constructed. The HEK-293T cell line overexpressing the CD63-iRGD-3×FLAG fusion protein and overexpressing the miR-25-3p antisense sequence was obtained by fluorescence sorting using flow cytometry, and exosomes in the culture supernatant of this cell line were obtained by ultracentrifugation. Treatment of pancreatic cancer was simulated by regular tail vein injections of BALB/c nu mice overexpressing CD63-iRGD-3×FLAG fusion protein and loaded with miR-25-3p antisense sequence. The liver and spleen of the mice were stained with HE after a certain course of treatment, and the effect of treatment with exosomes overexpressing CD63-iRGD-3×FLAG fusion protein and loaded with miR-25-3p antisense sequence on liver metastasis of pancreatic cancer was observed.
Results
There was a positive correlation between miR-25-3p and the invasive migration ability of pancreatic cancer cell lines in the Panc-1 and Panc-3 cell lines, and the invasive migration ability of pancreatic cancer was enhanced by overexpression of miR-25-3p (P < 0.05). Treatment with exosomes overexpressing the CD63-iRGD-3×FLAG fusion protein and loaded with the miR-25-3p antisense sequence slowed the weight loss of mice, and pancreatic cancer cell lines showed specific high uptake of such exosomes in mice. Treatment with exosomes overexpressing the CD63-iRGD-3×FLAG fusion protein loaded with the miR-25-3p antisense sequence significantly inhibited liver metastasis and spleen metastasis of pancreatic cancer in mice.
Conclusion
Exosomes overexpressing the CD63-iRGD-3×FLAG fusion protein and loaded with the miR-25-3p antisense sequence inhibited the invasive migration of pancreatic cancer cell lines both in vivo and ex vivo, which hopefully provides a new idea for molecular targeted therapy in the treatment of pancreatic cancer to improve the quality of life and prolong the survival time of pancreatic cancer patients.
A potential role for early hyponatremia in the diagnosis of Borna-virus encephalitis?
Authors: Lourbopoulos Athanasios , Schnurbus Lea , Guenther Ricarda , Steinlein Susanne , Ruf Viktoria , Herms Jochen , Jahn Klaus , Huge Volker 
Published: January 2023

Abstract
Background
The first case of fatal Borna Virus-1 encephalitis (BoDV-1) was reported in 2018. Here, we report another fatal case of BoDV-1 encephalitis with early severe hyponatremia, indicative of neurohypophysial dysfunction.
Case presentation:
A 77-year-old female living in southern Germany was admitted to hospital in 2020 due to rapidly progressing word-finding difficulties, personality changes, global disorientation, diffuse cognitive slowness, and gait ataxia, initially without fever. After a rapid deterioration with fever, gait instability and ataxia, rapid cognitive decline, meningism, epileptic seizures, aphasia, and signs of latent right hemiparesis, the suspicion of a (meningo-)encephalitis was set. Furthermore, an unexplained, severe hyponatremia had been present since admission. Laboratory workup in cerebrovascular fluid (CSF) and serum as well as brain imaging was negative. Despite extensive empirical antiviral, antimicrobial, and immunosuppressive treatment efforts, the patient fell into coma (day 5), lost all brainstem functions (day 18), and remained fully dependent on invasive mechanical ventilation. Finally, she clinically developed a status of brain death and died 42 days after initial admission. Brain autopsy confirmed an extensive, diffuse, and severe affection of neocortical, subcortical and cerebellar structures as well as the neurohypophysis due to infection with BoDV-1. In light of the autopsy results, the hyponatremia could imply an early basal brain involvement, which could narrow down the initial differential diagnosis.
Conclusion
The diagnosis of BoDV-1 encephalitis remains clinically challenging. The disease progresses quickly to irreversible brain damage. An early, unexplained, hyponatremia in the presence of severe and rapidly evolving encephalitis may narrow down the diagnosis.
Point Spread Functions of aberrated Leaky annular apertures with defect-of-focus
Authors: Sabitha N. , Rani S. Vidya , Venkanna M. , Sagar D. Karuna 
Published: January 2023

Abstract
The point spread function of the optical system in the presence of defocus and primary spherical aberration with the complex Hanning filter with amplitude and phase has been investigated. A substantial improvement in the intensity profile of the impulse response of the optical system has been achieved. When the optical system is subjected to higher orders of aberration and apodization, the optical system behaves like a super-resolver with lateral resolution of the central peak being improved radically. The presence of first minima with zero intensity suits the optical system to be applied for two-point resolution studies in terms of Rayleigh criterion.
CD147 promotes cisplatin resistance in ovarian cancer by inhibiting FOXM1 degradation via PI3k/Akt-GSK3β pathway
Authors: li yu , wang Miao , Fan Tian , Wang Yu , Chen Lin , Zhu Chunyu , Li Zhixian , Mou Lei , Zhang Zhen , Chen Lin , Ali Arshad , Dai Jing-yao , Yang Hong 
Published: January 2023

Abstract
CD147 is a transmembrane glycoprotein that is highly expressed in a number of human cancers, including ovarian cancer. The antibody drug Licartin®, which targets CD147, has been approved by the Chinese Food and Drug Administration (FDA) and entered clinical treatment. Some studies have shown that CD147 plays a role on drug resistance, but the molecular mechanism remains elusive. This study sought to investigate the role and mechanism of CD147 in cisplatin resistance of ovarian cancer. We found that CD147 regulated ubiquitination and degradation of FOXM1 by activating PI3k/Akt-GSK3β pathway in ovarian cancer cells and further regulated the expression of DNA damage repair genes. The CUT&Tag-seq data showed that FOXM1 can directly bind to the promoter regions of several DNA damage repair (DDR) genes such as BRIP1, RRM1, FEN1, RAD50, and PMS2, thereby regulating their transcription. The siRNA against CD147 decreased the expression of FOXM1 and DDR genes, attenuating cisplatin resistance of ovarian cancer in vivo and in vitro experiments. Our results showed a novel cisplatin-resistant mechanism and suggest that the combination of cisplatin with a CD147 suppression is a prospective treatment plan for ovarian cancer that is resistant to cisplatin.
Performance Analysis of Wireless Powered Uplink NOMA System with User Cooperation over Nakagami-m Fading Channels
Authors: N Deepan , B Rebekka , J Bala Vishnu , Ram Saswat Kumar 
Published: January 2023

Abstract
In this paper, we develop a novel user cooperation assisted wireless powered communication network(UC-WPCN) based on non-orthogonal multiple access (NOMA) protocol. The proposed network model consists of a two uplink user terminals, defined as UE1, and UE2, respectively, and one hybrid access point (HAP). Here, HAP is helps to coordinate the energy beamforming and information gathering for the user terminals. In this system, we assume that the both UE’s are energy constrained devices such that it first harvest energy from HAP in the downlink (DL) prior to the data transmission in the uplink (UL). In addition, we also assume that, the UE1 is located much closer to HAP than UE2, hence, a full-duplex (FD) relaying operation with power domain multiplexing techniques is exploited at UE1, in order to facilitate UE2 information transmission. A new form of mathematical expressions are derived, which then is used to evaluate the system performance such as outage probability, and sum throughput for the proposed system model. Further, an optimal power allocation scheme is introduce to minimize the system outage notably. Based on the numerical findings, it is clear that the proposed NOMA enabled UC-WPCN system enhances the cell edge user (i.e., UE2) performance significantly and experiences a larger system throughput as compared to existing UC-WPCN system. Furthermore, the accuracy of the derived theoretical results are validated through Monte-Carlo simulations.
Effect of gyroscopic moments on the attitude stability of a satellite in an elliptical orbit
Authors: Zhao Jie , Zhong Xue , Yu Kaiping , Xu Minqiang 
Published: January 2023

Abstract
The gyroscopic moments generated by flywheels or control moment gyroscopes have important applications in spacecraft attitude stability and control. However, most of the current research has focused on the effect of gyroscopic torques on the attitude stability of spacecrafts on circular orbits, with little discussion of the case of elliptical orbits. In this paper, we investigate the stability of a particular cylindrical precession in an elliptical orbit by simplifying the spacecraft to a dynamically symmetric gyrostat consisting of a rotor and a platform. In the case of circular orbits, the system discussed here is autonomous, whereas in the case of elliptical orbits it is a periodic Hamiltonian system. The stability of cylindrical precession has been investigated analytically for the case of circular orbits. In the case of elliptical orbits, Floquet theory was used to numerically obtain the unstable regions and linear stable regions of the cylindrical precession. The nonlinear stability was further investigated in the linear stability region of the cylindrical precession. The results indicated that, in the case of the circular orbit, the cylindrical precession can be stabilized as long as the gyroscopic moment is large enough. However, the system may lose its stability even if the gyroscopic torque is sufficiently large in an elliptical orbit. Moreover, we present the effect of gyroscopic moments on the stability of cylindrical precession in three different elliptical orbits with eccentricities of 0.05, 0.2, and 0.5, using stability diagrams.
A multiomic approach to examine the molecular signatures differentiating people with obesity alone from those with obesity and metabolic complications
Authors: Mir Fayaz , Mall Raghvendra , Ullah Ehsan , Iskandarani Ahmad , Cyprian Farhan , Samra Tareq A. , Alkasem Meis , Abdalhakam Ibrahem , Farooq Faisal , Taheri Shahrad , Abou-Samra Abdul-Badi 
Published: January 2023

Abstract
Motivation
To examine the hypothesis that obesity with metabolic syndrome, compared to simple obesity, has distinct molecular signatures and metabolic pathways.
Methods
We analyzed a cohort of 39 patients with obesity that includes 21 subjects with metabolic syndrome, age-matched to 21 subjects with simple obesity. We measured in whole blood samples 754 human microRNAs (miRNAs), 704 metabolites using unbiased mass spectrometry metabolomics, and 25,682 transcripts, which include both protein coding genes (PCGs) as well as non-coding transcripts. We then identified differentially expressed miRNAs, PCGs, and metabolites and integrated them using databases such as mirDIP (mapping between miRNA-PCG network), Human Metabolome Database (mapping between metabolite-PCG network) and tools like MetaboAnalyst (mapping between metabolite-metabolic pathway network) to determine dysregulated metabolic pathways in obesity with metabolic complications.
Results
We identified 8 significantly enriched metabolic pathways comprising 8 metabolites, 25 protein coding genes and 9 microRNAs which are each differentially expressed between the subjects with obesity and those with obesity and metabolic syndrome. By performing unsupervised hierarchical clustering on the enrichment matrix of the 8 metabolic pathways, we could approximately segregate the simple obesity strata from that of obesity with metabolic syndrome.
Conclusions
The data suggest that at least 8 metabolic pathways, along with their various dysregulated elements, identified via our integrative bioinformatics pipeline, can potentially differentiate the patients with obesity from those with obesity and metabolic complications.
Monitoring and management of Aceria litchii (Acari: Eriophyidae) in lychee orchard in São Paulo
Authors: Ramos João Tenorio , Mineiro Jeferson Luiz Carvalho , Sato Mario Eidi 
Published: January 2023

Abstract
Aceria litchii (Keifer) is considered one of the main pest of lychee, and can severely compromise the fruit production. The research was conducted with the objective of evaluating some strategies for the management of A. litchii and the associated erinose on lychee plants. The study was carried out in a commercial lychee orchard in Botucatu County, state of São Paulo, Brazil, using the following treatments: 1) Bordeaux mixture + lime sulfur; 2) Release of predatory mites (Neoseiulus californicus) + lime sulfur; 3) Lime sulfur (grower standard). Lychee leaf samples were collected monthly to evaluate the diversity of phytophagous (Eriophyidae) and predatory (Phytoseiidae) mites, and evaluate the population fluctuation of the most abundant mite species. We also evaluated the percentage of leaves with symptoms of erinose in shoots of lychee plants, for the different treatments. Phytoseius woodburyi De Leon (82.8%), Amblyseius herbicolus (Chant) (11.2%) and Amblyseius compositus Denmark & Muma (3.2%) were the most abundant species of predatory mites (Phytoseiidae) observed on the lychee plants. A significant correlation was observed between the population densities of A. litchii and P. woodburyi, indicating that this predatory mite represents an important natural enemy of the erinose mite. The use of the Bordeaux mixture and lime sulfur showed a significant effect in reducing the incidence of erinose and establishment of the pest mite in lychee orchard. The release of N. californicus contributed significantly to the reduction of the population density of A. litchii, as well as the percentage of leaves with erinose, in lychee plants.
Potential therapeutic targets for glioblastoma patients based on a prognostic risk model
Authors: Zhou Junlin , Li Feng 
Published: January 2023

Abstract
Purpose: Differentially expressed genes (DEGs) of glioblastoma (GBM) affects prognosis and the reason is unknown. In our analysis, we aimed to build a prognostic risk model, and find out some potential therapeutic targets.
Methods: The data were from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), and , we screened for (DEGs) related to overall survival (OS). The prognostic model related to DEGs were constructed by Lasso regression analysis and we verified that the model was associated with prognosis. Then GSEA enrichment analysis was used to explore the difference of KEGG signal pathway between high and low risk groups. In addition, we also studied the immune correlation characteristics between the high and low risk groups of the model and the drug sensitivity analysis of the positive contribution of the model risk.
Results: Six DEGs (PTPRN, PTPRN2, RUFY2, CRNDE, ZNF581, SLC25A48) significantly related to the prognosis of GBM were screened, and the model of DEGs related to prognosis of GBM was successfully constructed. In addition, several signal pathways might promote tumor progression in the high risk group. Drug sensitivity analysis of chemotherapeutic drugs based on model risk genes expression.
Conclusion: This model is not only an independent prognostic index of GBM, but also has higher prediction accuracy than