bluuebunny/crossref_metadata_2025_split huggingface dataset:
La gerencia y los procesos administrativos en las instituciones públicas venezolanas
Authors: Carmona Jesús Alberto , Villegas Flores Verónica Patricia , Willian Marcelo Buenaño López Willian Marcelo Buenaño López 
Published: February 2023

El propósito de esta investigación es determinar el nivel de correlación que existe entre la gerencia y los procesos administrativos en las instituciones educativas públicas venezolanas. Desde el punto de vista metodológico la investigación es de carácter descriptivo bajo un enfoque cuantitativo correlacional, se emplea un diseño de campo, Y se toma como muestra a vender docentes de diferentes instituciones educativas del país, El proceso de análisis se basa en el análisis de correlación de Pearson r. Los resultados indica que el nivel de correlación entre las variables gerencia y procesos administrativos es de r: 0,048117069, lo que significa que tiene una correlación positiva muy débil (Casi nula), sin embargo están asociadas en sentido directo, es decir que la gerencia tiene una relación muy significativa con los procesos administrativos en las instituciones públicas educativas de Venezuela. Las conclusiones señalan que en es importante señalar que la gerencia es la base fundamental de todos los procesos de gestión que se realizan en una inclusión educativa. Una gerencia basada en procesos ortodoxos y anticuados será una herencia que no producirá cambios en el tiempo para una institución educativa, de tal manera que se torna importante a nivel gerencial cambiar la respectiva y el enfoque gerencial para generar una transformación en cambio sustancial a nivel organizacional y estructural en una Institución educativa. Drucker (1973), indica que para poder sobrevivir y prosperar, toda organización debe convertirse en un agente de cambio. La manera más efectiva y eficaz de manejar el cambio es crearlo, pero la experiencia ha demostrado que insertar innovaciones en nos da buenos resultados.
A New Physical Picture for Active Galactic Nuclei Lacking Optical Emission Lines
Authors: Agostino Christopher J. , Salim Samir , Ellison Sara L. , Bickley Robert W. , Faber S. M. 
Published: February 2023

Abstract
In this work, we use ∼500 low-redshift (z ∼ 0.1) X-ray active galactic nuclei (AGNs) observed by XMM-Newton and the Sloan Digital Sky Survey (SDSS) to investigate the prevalence and nature of AGNs that apparently lack optical emission lines (“optically dull AGNs”). Although one quarter of spectra appear absorption-line dominated in visual assessment, line extraction with robust continuum subtraction from the MPA/JHU catalog reveals usable [O iii] measurements in 98% of the sample, allowing us to study [O iii]-underluminous AGNs together with more typical AGNs in the context of the L
[O III]–L
X relation. We find that “optically dull AGNs” do not constitute a distinct population of AGNs. Instead, they are the [O iii]-underluminous tail of a single, unimodal L
[O III]–L
X relation that has substantial scatter (0.6 dex). We find the degree to which an AGN is underluminous in [O iii] correlates with the specific star formation rate or D
4000 index of the host, which are both linked to the molecular gas fraction. Thus the emerging physical picture for the large scatter seems to involve the gas content of the narrow-line region. We find no significant role for previously proposed scenarios for the presence of optically dull AGNs, such as host dilution or dust obscuration. Despite occasionally weak lines in SDSS spectra, >80% of X-ray AGNs are identified as such with the Baldwin–Phillips–Terlevich diagram. More than 90% are classified as AGNs based only on [N ii]/Hα, providing more complete AGN samples when [O iii] or Hβ are weak. X-ray AGNs with LINER spectra obey essentially the same L
[O III]–L
X relation as Seyfert 2s, suggesting their line emission is produced by AGN activity.
Un chevalier dans la tourmente révolutionnaire : les ancêtres français de Virginia Woolf et de Julia Margaret Cameron
Authors: Lessens Ronald 
Published: February 2023

La photographe victorienne Julia Margaret Cameron (1815-1879) et l’écrivaine Virginia Woolf (1882-1941) étaient parentes, puisque Maria Pattle, sœur de la photographe (née Julia Margaret Pattle), était la grand-mère de l’écrivaine. Les nombreuses biographies consacrées aux deux artistes mentionnent sans réellement s’y attarder un ancêtre quelque peu mythique, le « chevalier de L’Étang ». Virginia Woolf, dans son Journal intégral , a plusieurs fois fait référence à quelques ancêtres, mais il semble que ses connaissances n’allaient pas au-delà de ce que la tradition familiale lui avait transmis. C’est sur les traces de ce mystérieux chevalier que se lance cet article, fondé sur un minutieux travail d’archives. Il ne propose pas une étude littéraire de l’œuvre de Woolf, ni une analyse artistique des photographies de Cameron, mais plutôt une enquête de type généalogique et historique sur des antécédents familiaux lointains qui éclairent aussi un pan de l’histoire de la présence anglaise dans le sud de l’Inde. L’article commence par retracer la légende du chevalier, avant de pousser plus avant dans les documents d’archives.
Transcendance et totalité. Bonhoeffer, la phénoménologie et la figure de l’« homme parfait »
Authors: Mariani Emanuele 
Published: February 2023

Pourquoi recourir à la pensée de Dietrich Bonhoeffer pour formuler une contribution philosophique au problème de la tolérance ? Et, de surcroît, en dialogue avec la phénoménologie ? Homme de pensée et d’action, Bonhoeffer n’est, à proprement parler, ni un phénoménologue ni un penseur de la tolérance. Il est, toutefois, légitime d’envisager sa lutte contre le totalitarisme, tant sur le plan théologique que politique, comme un cas limite susceptible de relever du questionnement sur la nature et la portée de la tolérance elle-même. Et cela en raison du paradoxe auquel Bonhoeffer s’expose dans la tentative de putsch visant l’élimination du Führer à laquelle il participe : la violation non seulement de la loi, mais d’un commandement divin – « tu ne tueras pas » – que Bonhoeffer justifie au nom de sa foi en Dieu. Notre hypothèse de lecture nous conduit dès lors à consacrer une attention particulière à sa thèse d’habilitation, Akt und Sein , où Bonhoeffer formule une critique originale de la phénoménologie notamment heideggérienne, inspirée par la theologia crucis de tradition luthérienne : renonçant à toute tentative d’autodétermination, l’homme, pour Bonhoeffer, ne peut se comprendre que par une ouverture radicale à la transcendance qui coïncide, en dernière instance, avec la dimension authentiquement personnelle de l’homme lui-même ainsi que de la relation entre l’homme et Dieu.
Jacques Derrida, l’hospitalité au-delà de la tolérance et l’intolérance au cœur de l’hospitalité
Authors: Lindberg Susanna 
Published: February 2023

Jacques Derrida a formulé une importante critique du concept de tolérance hérité des Lumières. Évidemment, il ne recommande pas l’intolérance, mais il en appelle à une autre forme de tolérance réinterprétée dans le cadre d’une éthique plus générale de l’hospitalité. La parution en 2021 du volume 1 de son séminaire Hospitalité (EHESS, 1995-1996) permet de préciser ses concepts de l’hospitalité conditionnelle et de l’hospitalité inconditionnelle, ainsi que leur enchevêtrement aporétique. Cet article présente son concept d’hospitalité au-delà de la tolérance, mais découvre aussi une in/tolérance au cœur de l’hospitalité. Celle-ci est enracinée dans le concept de vie que Derrida examine en termes d’auto-immunité : ce sont les réactions de la tolérance et de l’intolérance propres à la vie qui mettent à mal la pensée de l’hospitalité, en sorte que la pensée de l’hospitalité présuppose une in/tolérance qu’elle commande de surpasser.
Activité historienne et appartenance urbaine
Authors: Bernstein Hilary J. 
Published: February 2023

Cet article porte sur un genre manuscrit d’histoire urbaine à la ville de Poitiers au xvii e siècle : les listes des maires de la ville, accompagnées de courts textes expliquant les évènements les plus importants de leurs mandats. Ces annales offraient un espace écrit privilégié pour essayer d’établir une mémoire urbaine particulière tout en interrogeant ce que cette histoire voulait dire pour la communauté et les factions politiques et sociales qui la composaient. Certaines d’entre elles ont été incorporées aux archives officielles de l’Hôtel de Ville tandis que d’autres sont restées dans les collections privées. Au travers d’un processus d’écriture, de réécriture et d’emprunt s’étalant sur plusieurs générations, de multiples auteurs insistèrent sur l’importance de leurs familles notables, tout en essayant d’imposer leurs vues sur les divisions religieuses et politiques du passé, en particulier les guerres de Religion et les révoltes des princes du début du xvii e siècle.
Activité historienne et appartenance urbaine
Authors: Coulomb Clarisse 
Published: February 2023

Claude Beneyton (1698-1772), est un entrepreneur en bâtiment de Saint-Étienne auteur d’une histoire chronologique de sa ville. Il s’inscrit dans une tradition annalistique vivante chez les artisans : la chronique des événements est un acte de citoyenneté à un moment où les corps de villes se ferment (Amelang, Cassan, Ruggiu). Cependant, Beneyton est original par sa dénonciation du contrôle opéré par les manufactures sur le travail des ouvriers ainsi que la captation du pouvoir municipal par les entrepreneurs des armes. L’écriture du passé et la chronique des événements auxquels il assiste lui fait prendre conscience de la formation d’une nouvelle identité urbaine, celle d’une « pauvre ville » livrée aux forces économiques appuyées par les pouvoirs politiques. Cette « conscience ouvrière », selon les termes d’Edward P. Thompson, est le fruit de son activité savante, et c’est pour cela qu’il se bat pour être publié et faire accéder le peuple à l’éducation : seule celle-ci peut faire advenir une société de mérite, où les travailleurs devenus citoyens, seront capables de mettre fin à la société corrompue.
Kant on Consciousness and Its Limits
Authors: Longuenesse Béatrice 
Published: February 2023

Le présent essai tente de tirer au clair les différentes significations des termes « conscient » et « conscience » dans la philosophie critique de Kant et en particulier dans la Critique de la raison pure . On considère d’abord les divers types de représentations et ce que veut dire Kant lorsqu’il les dit « avec » ou « sans » conscience. On considère ensuite le concept de conscience tel qu’il apparaît dans la Déduction transcendantale des catégories, où il ne réfère pas à une qualité de représentations particulières, mais à une attitude active de l’esprit. Considérée dans son ensemble, la conception kantienne de la « conscience » mêle inséparablement un aspect que nous appelons, après T. Nagel, « conscience phénoménale », et un aspect proche de la « conscience d’accès » selon N. Block, dans lequel cependant la conscience de soi, exprimable par la proposition « Je pense », joue un rôle central. Cette combinaison fait de Kant un interlocuteur unique dans les débats contemporains sur la conscience et son rôle dans notre vie mentale, ainsi que sur l’IA et sa signification pour l’avenir de l’humanité.
Thymic microbiota-specific T cells role in intestinal inflammation
Authors: Ruiz Daniel Fernando Zegarra , Kim Dasom , Norwood Kendra , Wu Wan-Jung , Saldana-Morales Fatima , Bettini Matthew , Diehl Gretchen 
Published: February 2023

Abstract
Inflammatory bowel disease (IBD) patients, including Crohn’s disease and ulcerative colitis, exhibit dysregulated immune responses. Although IBD etiology remains uncertain, microbiota-reactive T cells are thought to play a role in pathogenesis. It has been shown that gut microbiota and their metabolites play a role in modulating mucosal immune responses and thus, have the potential to influence the development of IBD. Although host-microbe interactions are required to balance effector and regulatory T cells responses, it remains unknown how microbiota-specific T cells are generated. Here we studied how microbiota-specific T cells develop and how they can drive intestinal inflammation. Colonization of mice at weaning induced the expansion of naive microbiota-specific T cells in the thymus before peripheral distribution. Transfer of naive thymic microbiota-specific T cells into immunodeficient mice induced intestinal inflammation by differentiating into Th1 or Th17 cells. We identified that CX3CR1+ dendritic cells (CX3+DCs) were required for this process, as depleting these cells decreased the expansion of thymic microbiota-specific T cells. Transfer of thymic T cells from mice lacking CX3+ DCs induced less colitis in immunodeficient mice compared to wildtype donors. Moreover, inhibiting CX3+ DCs antigen-presentation suppressed induction of microbiota-specific T cells and transfer of these cells promoted less intestinal inflammation. Together, our data suggests CX3+ DCs drive T cell selection of microbiota-specific T cells in the thymus, which can differentiate into intestinal effector T cells mediating pathology in immunodeficient hosts.
Gut microbiota dysbiosis and altered bile acid catabolism lead to metabolic disorder in psoriasis mice
Authors: HAO YAN , ZHAO QIXIANG , ZOU SONG , ZHOU PEI , HU YAWEN , ZHU YAJUAN , YU JIADONG , ZHOU HONG , WANG ZHEN , ZHENG HUAPING , ZENG FANLIAN , GU LINNA , YUE CHENGCHENG , LI JIONG 
Published: February 2023

Abstract
Patients with psoriasis tend to have significant comorbidities, such as hypertension, diabetes mellitus and obesity, which belong to metabolic disorder. The specific pathways through which psoriasis increases metabolic disorder risk is uncertain. The gut microbiome and gut associated metabolites as important regulators of host energy and substrate metabolism are intricately linked to host metabolic homeostasis. Here we demonstrated that the dysbiotic gut microbiota of aged psoriasis-like model mice(6 months K14-VEGF) exacerbated psoriasis disease and induced the emergence of metabolic disorder when transferred into young mice(2 months K14-VEGF). We used 16S rRNA gene sequencing detected the decrease of Parabacteroides distasonis, an intestinal bacterium, in aged K14-VEGF mice. It has been reported that Parabacteroides distasonis can affect the distribution of bile acid metabolism and benefits the metabolism of host. Metabolomic screening identified an altered distribution of bile acid metabolites, including a decrease in chenodeoxycholic acid(CDCA) in the feces of transferred mice. In addition, supplement with dietary CDCA prevented metabolic disease in K14-VEGF mice. Consequently, we found that aberrant bile acid metabolism may contribute to metabolic disorder in K14-VEGF mice, indicating the possibility to prevent and treat the metabolic disorder by targeting gut microbial metabolites in psoriasis mice.
Eosinophils inhibit breast cancer pulmonary metastatic colonization and directly kill tumor cells via degranulation
Authors: Cederberg Rachel , Bennewith Kevin L 
Published: February 2023

Abstract
Metastatic breast cancer remains incredibly challenging to treat, highlighting the need for an improved understanding of host factors that prevent metastasis, as well as improved therapeutics to treat metastatic cancer. The lungs, which are one of the most common sites of breast cancer metastasis, are host to a variety of immune cell subsets, including eosinophils (Eo), which are innate immune cells that target pathogens via the secretion of cytotoxic granule proteins. Eo have been shown to be anti-tumorigenic when exposed to certain signals from their local microenvironment. To study the role of eosinophils in pulmonary breast cancer metastasis, we utilized transgenic mouse models of eosinophilia (IL5Tg mice) and eosinophil-deficiency (ddGATA mice). EO771 breast cancer cells were injected intravenously (IV) to seed the lungs. We found that IL5Tg mice, which have a systemic expansion of Eo, had significantly lower EO771 lung tumor burden compared to WT mice. We found that Eo-deficient ddGATA mice exhibited accelerated metastatic progression compared to both WT and IL5Tg mice injected IV with EO771 cells. We also found that WT mice had an increased number of lung EO771 tumor cells compared to IL5Tg mice merely 5 days post-IV injection, indicating that Eo may play a role in both initial tumor cell seeding and subsequent metastatic nodule progression. Importantly, we found that Eo co-cultured with EO771 and LLC tumor cells released eosinophil peroxidase, a cytotoxic granule protein, resulting in tumor cell killing. These results highlight a role for Eo in preventing tumor cell colonization to metastatic sites and suggest that developing drugs to trigger Eo degranulation may serve as a viable therapeutic option to treat metastatic disease.
Identification of a macrophage activation threshold associated with malignant transformation and the sensing of candidate “danger signals”
Authors: Jacqueline Camille , Gottschalk Rachel , Minden Jonathan , Finn Olivera J 
Published: February 2023

Abstract
Cancer immunosurveillance is based on the recognition of changes brought by malignant transformation of normal cells, leading to their elimination, immunoediting, or escape. The ability of immune cells to sense changes associated with malignant transformation as early as possible is likely to be important for the successful outcome of cancer immunosurveillance. In this process, the immune system faces a trade-off between elimination of cells harboring premalignant or malignant changes, and autoimmune pathologies. We hypothesized that the immune system has therefore evolved a threshold for distinguishing normal from abnormal cells, perhaps similar to a pathogen recognition threshold at which macrophages distinguish non-dangerous from dangerous microbes. We co-cultured human macrophages with a unique set of genetically related human cell lines that recapitulate breast cancer development: MCF10A (immortalized); MCFneoT (hyperplasia); MCFT1 (atypical hyperplasia); MCFCA1 (invasive cancer). Using cytokines-based assays, we found that the threshold for macrophage activation was between MCFNeoT and MCFT1, with macrophages co-cultured with the atypical hyperplasia and invasive cancer cell lines showing an inflammatory cytokine response. This response was accompanied by an increase in macrophage migration, phagocytosis and capacity to infiltrate MCFT1 spheroids. We are currently validating candidates for “danger signals” that will be shared by MCFT1 and MCFCA1 but absent or expressed at low level in the early state of premalignancy. Using proteomic and transcriptomic approaches, we identified 13 surface or secreted molecules corresponding to this definition, some of which are well-known tumor-associated antigens.
Dendritic cells dysfunction in tumor-draining lymph nodes
Authors: Bandola-Simon Joanna Marta , Roche Paul A 
Published: February 2023

Abstract
An effective anti-tumor response requires activation of both CD4 helper T cells (through MHC-II) and CD8 cytotoxic T cells (through MHC-I). Activation of tumor-specific T cells depends on tumor antigen presentation by DCs. However, it is known that the tumor microenvironment largely suppresses immune responses. The focus of our study is to characterize the functional status of DCs in tumor-draining lymph nodes and to identify the mechanisms that lead to defective presentation of tumor antigens. We transplanted tumors into the flank of mice and analyzed DCs from both tumor-draining lymph node (TDLN) and non-draining lymph nodes (NDLN) as our model system. Cross-presentation of OVA to CD8 T cells was not suppressed in TDLN in comparison to the NDLN either in vivo or ex vivo. However, both in vivo and ex vivo CD4 T cell activation by DCs from TDLNs was defective. Subset analysis revealed that both migratory and resident DCs in TDLN show a less mature phenotype as compared to their counterparts isolated from NDLN. Functional assays revealed defects in antigen uptake and processing in DCs from TDLN. We also identified differences in the proportion of MHC-II molecules containing the Invariant chain CLIP peptide in DCs from TDLN in comparison to NDLN. These features of DC function, supported by RNA-Seq analysis, contribute to defective antigen presentation to CD4 T cells and may explain the dysfunction of DCs in tumor-bearing mice. Further analysis should enable moving towards “correcting” DC defects that would allow CD4 T cell priming to provide help to anti-tumor CD8 T cells.
Gemcitabine treatment modulates myelopoiesis progenitors and monocytes to promote lung metastasis
Authors: Ding Chuanlin , Yan Jun 
Published: February 2023

Abstract
Metastasis-associated macrophages (MAMs) play important roles in tumor metastasis through the formation of a pre-metastatic niche. In mouse models of lung metastasis, interstitial macrophages (IMs) markedly accumulate in the lungs and differentiate into MAMs. Regarding the origin of IMs/MAMs, tissue-resident macrophages and bone marrow (BM)-derived classical monocytes (BM-Mo) contribute to the pool of MAMs. Chemotherapy offers long-term clinical benefits to many cancer patients. However, several pre-clinical studies have demonstrated that certain cytotoxic drugs enhance metastasis by multiple mechanisms. Our recent studies suggest that Gemcitabine (GEM) promotes the immunosuppressive function of monocytic MDSC (M-MDSC) in the tumor microenvironment via the tumor-derived GM-CSF and efferocytosis signaling. In this study, we hypothesize that host responses to GEM treatment enhance the accumulation of BM-derived monocytes in lung, which promotes lung metastasis. Multi-dose of GEM treatment induces the increase of BM LSK cells and multipotent progenitors (MPPs) in tumor-free mice, which is associated with the increase of treatment induce mitochondrial ROS (mtROS). Thus, the percentage of BM Ly6C+ monocytes is significantly increased because of increased progenitor monocyte differentiation potential and monocyte proliferation. Further, GEM treatment increases the percentages of lung CCR2+Ly6C+ monocytes and IMs. Consequently, GEM pre-treated mice have a significantly higher number of pulmonary metastases compared to untreated mice in the experimental metastasis model. These results suggest a novel mechanism for chemotherapy induced metastasis via the modulation of myelopoiesis progenitors.