bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipsychotic medication use and fracture: a case–control study
Authors: Azimi Manavi Behnaz , Stuart Amanda L. , Pasco Julie A. , Hodge Jason M. , Weerasinghe D. Kavindi , Samarasinghe Rasika M. , Williams Lana J. 
Published: August 2023

AbstractIt has been reported that antipsychotic use is associated with lower bone mineral density and bone quality. We aimed to determine whether antipsychotic use is associated with fracture risk in a population-based sample of adults living in the Barwon Statistical Division, south-eastern Australia. In this case–control study, 1458 participants (51.8% women) with radiologically confirmed fracture between June 1st 2012 and May 31st 2013 (cases) were compared with 1795 participants (46.5% women) without fracture (controls) for the same time period. Medication use, medical history and lifestyle factors were documented by self-report. Multivariable binary logistic regression was used to explore associations between antipsychotic use and fracture following adjustment for possible confounders. In women, antipsychotic use was identified for 20 of 755 (2.6%) cases and 10 of 834 (1.2%) controls (p = 0.034) and in men, antipsychotic use was identified for 13 of 703 (1.8%) cases and 5 of 961 (0.5%) controls (p = 0.010). Following adjustments, antipsychotic use was associated with a 3.0-fold increased risk of fracture in men and a 2.3-fold increased risk of fracture in women. Patterns persisted after exclusion of participants with non-fragility fractures and self-reported schizophrenia. While future research exploring underlying mechanisms is needed, regular monitoring of bone health in antipsychotic users is suggested.
Improvement of lateral property of unidirectional-strengthened CFRP laminates using recycled carbon fiber
Authors: Melinda Annisa Prita , Yamamoto Rino , Miyasaka Yuichi , Yoresta Fengky Satria , Imai Yusuke , Sugimoto Yoshiki , Nomura Kazuki , Matsumoto Yukihiro 
Published: August 2023

AbstractThe unidirectional carbon fiber reinforced polymer (UD-CFRP) lacks the modulus of elasticity and strength in the lateral direction. This study investigates whether matrix resin with CFRP waste, recycled carbon fiber (rCF), can improve the lateral properties of CFRP. In total, twelve CFRP strips specimen were prefabricated of unidirectional carbon fiber (CF) sheet by hand lay-up (HLU) method and were tested by tensile test and X-ray computed tomography (X-ray CT). Factors such as fiber direction and void distribution significantly affecting its mechanical properties are assessed by X-ray CT inspection. It can be seen that rCF is mixed in a random direction at the position filled with matrix resin without rCF. However, a similar frequency of unimpregnation and voids can be observed in both specimens. Test results showed that experimental values of CFRP laminates with rCF-mixed matrix resin increased compared to the CFRP laminates without rCF. The percentage increase in the lateral tensile strength and modulus of elasticity of the rCFRP compared to the control specimen without rCF is 27.36% and 10.62%, respectively. This study proved that rCF can increase the lateral properties of unidirectional CFRP and shows the effective use of rCF for strengthening material in construction applications.
Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences
Authors: Zeifman Richard J. , Kettner Hannes , Pagni Broc A. , Mallard Austin , Roberts Daniel E. , Erritzoe David , Ross Stephen , Carhart-Harris Robin L. 
Published: August 2023

AbstractPsilocybin and lysergic acid diethylamide (LSD) experiences can range from very positive to highly challenging (e.g., fear, grief, and paranoia). These challenging experiences contribute to hesitancy toward psychedelic-assisted psychotherapy among health care providers and patients. Co-use of 3,4-Methylenedioxy methamphetamine (MDMA) with psilocybin/LSD anecdotally reduces challenging experiences and enhances positive experiences associated with psilocybin/LSD. However, limited research has investigated the acute effects of co-use of MDMA and psilocybin/LSD. In a prospective convenience sample (N = 698) of individuals with plans to use psilocybin/LSD, we examined whether co-use of MDMA with psilocybin/LSD (n = 27) is associated with differences in challenging or positive experiences. Challenging experiences were measured using the Challenging Experiences Questionnaire and positive experiences were measured using the Mystical Experience Questionnaire and single-item measures of self-compassion, compassion, love, and gratitude. Potentially confounding variables were identified and included as covariates. Relative to psilocybin/LSD alone, co-use of psilocybin/LSD with a self-reported low (but not medium–high) dose of MDMA was associated with significantly less intense total challenging experiences, grief, and fear, as well as increased self-compassion, love and gratitude. Co-use of psilocybin/LSD and MDMA was not associated with differences in mystical-type experiences or compassion. Findings suggest co-use of MDMA with psilocybin/LSD may buffer against some aspects of challenging experiences and enhance certain positive experiences. Limitations include use of a convenience sample, small sample size, and non-experimental design. Additional studies (including controlled dose–response studies) that examine the effects and safety of co-administering MDMA with psilocybin/LSD (in healthy controls and clinical samples) are warranted and may assist the development of personalized treatments.
The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats
Authors: Shigemi Shohei , Sato Tadasu , Sakamoto Mayuri , Yajima Takehiro , Honda Takahiro , Tsumaki Hiroka , Deguchi Toru , Ichikawa Hiroyuki , Fukunaga Tomohiro , Mizoguchi Itaru 
Published: August 2023

AbstractWhen orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that responds to various stimuli, including mechanical stress, and involved in calcium oscillations during the early stages of osteoclast differentiation. However, in vivo expression of TRPV2 in osteoclasts has not yet been reported, and temporo-spatial expression of TRPV2 during osteoclast differentiation is unclear. In this study, we examined the TRPV2 expression during experimental tooth movement and assessed the effect of TRPV2 on osteoclast differentiation. TRPV2 was detected on day 1 after experimental tooth movement on the compression side, and the number of TRPV2-expressing cells significantly increased on day 7. These TRPV2-expressing cells had a single, or multiple nuclei and were positive for TRAP activity. Consistent with these in vivo findings, in vitro experiments using RAW264.7 osteoclast progenitor cells showed that TRPV2 mRNA was increased at the early stage of osteoclast differentiation and maintained until the late stage. Furthermore, a TRPV2 channel selective antagonist significantly inhibited osteoclast differentiation. These findings suggest that TRPV2 may have a regulatory role in osteoclast differentiation during orthodontic tooth movement.
Digital transformation of mental health services
Authors: Bond Raymond R. , Mulvenna Maurice D. , Potts Courtney , O’Neill Siobhan , Ennis Edel , Torous John 
Published: August 2023

AbstractThis paper makes a case for digital mental health and provides insights into how digital technologies can enhance (but not replace) existing mental health services. We describe digital mental health by presenting a suite of digital technologies (from digital interventions to the application of artificial intelligence). We discuss the benefits of digital mental health, for example, a digital intervention can be an accessible stepping-stone to receiving support. The paper does, however, present less-discussed benefits with new concepts such as ‘poly-digital’, where many different apps/features (e.g. a sleep app, mood logging app and a mindfulness app, etc.) can each address different factors of wellbeing, perhaps resulting in an aggregation of marginal gains. Another benefit is that digital mental health offers the ability to collect high-resolution real-world client data and provide client monitoring outside of therapy sessions. These data can be collected using digital phenotyping and ecological momentary assessment techniques (i.e. repeated mood or scale measures via an app). This allows digital mental health tools and real-world data to inform therapists and enrich face-to-face sessions. This can be referred to as blended care/adjunctive therapy where service users can engage in ‘channel switching’ between digital and non-digital (face-to-face) interventions providing a more integrated service. This digital integration can be referred to as a kind of ‘digital glue’ that helps join up the in-person sessions with the real world. The paper presents the challenges, for example, the majority of mental health apps are maybe of inadequate quality and there is a lack of user retention. There are also ethical challenges, for example, with the perceived ‘over-promotion’ of screen-time and the perceived reduction in care when replacing humans with ‘computers’, and the trap of ‘technological solutionism’ whereby technology can be naively presumed to solve all problems. Finally, we argue for the need to take an evidence-based, systems thinking and co-production approach in the form of stakeholder-centred design when developing digital mental health services based on technologies. The main contribution of this paper is the integration of ideas from many different disciplines as well as the framework for blended care using ‘channel switching’ to showcase how digital data and technology can enrich physical services. Another contribution is the emergence of ‘poly-digital’ and a discussion on the challenges of digital mental health, specifically ‘digital ethics’.
Optimizing the hybrid PVDG and DSTATCOM integration in electrical distribution systems based on a modified homonuclear molecules optimization algorithm
Authors: Belbachir Nasreddine , Kamel Salah , Hashim Fatma A. , Yu Juan , Zeinoddini‐Meymand Hamed , Sabbeh Sahar F. 
Published: August 2023

AbstractThe increasing use of non‐linear loads in electrical distribution systems (EDS) led to a greater need for reactive power compensation, losses minimization, improved voltage and stability. This paper proposes the optimal integration of hybrid photovoltaic distributed generation (PVDG) and distribution static synchronous compensator (DSTATCOM) into IEEE 33 and 69‐bus EDS. A modified version of homonuclear molecules optimization (mHMO) is developed to determine the optimal allocation of the devices, while minimizing a multi‐objective function (MOF) based on total active power losses (TAPL), total voltage deviation (TVD), and investment cost of integrated devices (ICPVDG and ICDSTATCOM). The primary objective of the mHMO is to enhance the equilibrium between exploration and exploitation in the original HMO by implementing a fresh exploration stage. The effectiveness of mHMO was assessed using CEC17 benchmark functions. The findings demonstrate that mHMO achieved excellent results, including high‐quality solution and a favourable convergence rate. Additionally, results demonstrate that mHMO outperforms its basic version in reducing TAPL by 94.27% and 97.87% for the two EDS, while improving voltage profiles and reducing the cost of integrated devices. This study shows the potential of hybrid PVDG‐DSTATCOM in improving the performance of EDS and highlights the effectiveness of mHMO in optimizing their integration.
Reeling in the Whirlpool galaxy: Distance to M 51 clarified through Cepheids and the type IIP supernova 2005cs
Authors: Csörnyei G. , Anderson R. I. , Vogl C. , Taubenberger S. , Blondin S. , Leibundgut B. , Hillebrandt W. 
Published: August 2023

Context. The distance to the Whirlpool galaxy, M 51, is still debated, even though the galaxy has been studied in great detail. Current estimates range from 6.02 to 9.09 Mpc, and different methods yield discrepant results. No Cepheid distance has been published for M 51 to date.
Aims. We aim to estimate a more reliable distance to M 51 through two independent methods: Cepheid variables and their period-luminosity relation, and an augmented version of the expanding photosphere method (EPM) on the type IIP supernova SN 2005cs, which exploded in this galaxy.
Methods. For the Cepheid variables, we analysed a recently published Hubble Space Telescope catalogue of stars in M 51. By applying filtering based on the light curve and colour-magnitude diagram, we selected a high-quality sample of M 51 Cepheids to estimate the distance through the period-luminosity relation. For SN 2005cs, an emulator-based spectral fitting technique was applied, which allows for the fast and reliable estimation of the physical parameters of the supernova atmosphere. We augmented the established framework of EPM with these spectral models to obtain a precise distance to M 51.
Results. The two resulting distance estimates are DCep = 7.59 ± 0.30 Mpc and D2005cs = 7.34 ± 0.39 Mpc using the Cepheid period-luminosity relation and the spectral modelling of SN 2005cs, respectively. This is the first published Cepheid distance for this galaxy. The obtained values are precise to 4–5% and are fully consistent within 1σ uncertainties. Because these two estimates are completely independent, they can be combined for an even more precise estimate, which yields DM 51 = 7.50 ± 0.24 Mpc (3.2% uncertainty).
Conclusions. Our distance estimates agree with most of the results obtained previously for M 51, but they are more precise than the earlier counterparts. However, they are significantly lower than the TRGB estimates, which are often adopted for the distance to this galaxy. The results highlight the importance of direct cross-checks between independent distance estimates so that systematic uncertainties can be quantified. Because of the large discrepancy, this finding can also affect distance-sensitive studies and their discussion for objects within M 51, as well as the estimation of the Hubble constant through the type IIP standardizable candle method, for which SN 2005cs is a calibrator object.
Notfälle in der Medikamentösen Tumortherapie
Authors: Handke Analena , Hilser Thomas , Bögemann Martin , Schlack Katrin , Grünwald Viktor 
Published: August 2023

Zusammenfassung
Hintergrund Immunmodulatorische Therapien gewinnen immer größere Bedeutung in der Uro-Onkologie. Aus diesem Grund werden wir vermutlich immer häufiger mit Nebenwirkungen konfrontiert werden. Hinzu kommt eine immer größere Zahl an Kombinationen mit anderen Wirkmechanismen. Als Folge dieser Therapie können immun-vermittelte Nebenwirkungen auftreten. Diese unterscheiden sich von den Nebenwirkungen einer Chemotherapie und anderen zielgerichteten Therapien und erfordern daher andere Behandlungsstrategien.

Ziel der Arbeit Anhand der aktuellen Literatur werden die Daten zur Graduierung und stadienabhängigen Management dargelegt sowie mit Beispielen aus der Praxis anschaulich dargestellt.

Material und Methoden Literaturrecherche zur Detektion und Therapiemanagement von im Rahmen der immunonkologischen Therapie vermittelten Nebenwirkungen.

Ergebnisse Die behandlungsbezogenen Ereignisse können prinzipiell alle Organsystem betreffen, häufig sehen finden sich Toxizitäten im Bereich der Haut, wie Ausschlag oder Pruritus, Hypo- oder Hyperthyreosen, Arthritiden, Muskelschmerzen und gastrointestinale Symptome. In der Häufigkeit sind die meisten Nebenwirkungen Grad 1 bis 2 zuzuordnen, jedoch auch Grad 3 bis 4 Toxizitäten sind grundsätzlich gut zu therapieren, sofern sie frühzeitig erkannt werden. Seltene Komplikationen wie neurologische Toxizitäten, Pneumonitis oder auch Karditis können bei zu später Diagnose einen fulminanten Verlauf entwickeln.

Diskussion Selbst Notfälle sind gut zu managen, wenn wir die wichtigsten Nebenwirkungen und therapeutischen Optionen kennen. Dabei kommt den immunvermittelten Nebenwirkungen ein besonderer Stellenwert zu, weil sie grundsätzlich jedes Organsystem betreffen können. So lange wir jedoch bei Patienten, die Symptome zeigen, an die Möglichkeit einer Toxizität durch Checkpointinhibitoren denken, sind die meisten Nebenwirkungen gut zu therapieren und daher kontrollierbar.
Development of Weight and Height Age z-Score after Total Cavopulmonary Connection
Authors: Bilic Carlo , Staehler Helena , Niedermaier Carolin , Schaeffer Thibault , Cuman Magdalena , Heinisch Paul Philipp , Burri Melchior , Piber Nicole , Hager Alfred , Ewert Peter , Hörer Jürgen , Ono Masamichi 
Published: August 2023

Abstract
Objective We aimed to analyze somatic growth of patients after total cavopulmonary connection (TCPC) as well as to identify factors influencing postoperative catch-up growth.
Methods A total of 309 patients undergoing TCPC at 4 years old or less between 1994 and 2021 were included. Weight for age z-score (WAZ) and height for age-z-score (HAZ) at TCPC and at postoperative time between 1 and 3 years were calculated. Factors influencing somatic growth were analyzed.
Results Most frequent diagnosis and initial palliation were hypoplastic left heart syndrome (HLHS) (34%) and the Norwood procedure (51%), respectively. Median age and weight at TCPC were 2.0 (IQR: 1.7–2.5) years and 11.3 (10.5–12.7) kg, respectively. Median 519 days after TCPC, a significant increase in WAZ (−0.4 to −0.2, p < 0.001) was observed, but not in HAZ (−0.6 to −0.6, p = 0.38). Older age at TCPC (p < 0.001, odds ratio [OR]: 2.6) and HLHS (p = 0.007, OR: 2.2) were risks for low WAZ after TCPC. Older age at TCPC (p = 0.009, OR: 1.9) and previous Norwood procedure (p = 0.021, OR: 2.0) were risks for low HAZ after TCPC. Previous bidirectional cavopulmonary shunt (BCPS) was a protective factor for both WAZ (p = 0.012, OR: 0.06) and HAZ (p = 0.028, OR: 0.30) at TCPC.
Conclusion In patients undergoing TCPC at the age of 4 years or less, a significant catch-up growth was observed in WAZ after TCPC, but not in HAZ. Previous BCPS resulted to be a protective factor for a better somatic development at TCPC. HLHSs undergoing Norwood were considered as risks for somatic development after TCPC.
Resistance Training Intensity Prescription Methods Based on Lifting
Velocity Monitoring
Authors: Ramos Amador García 
Published: August 2023

AbstractResistance training intensity is commonly quantified as the load lifted relative
to an individual's maximal dynamic strength. This approach, known as
percent-based training, necessitates evaluating the one-repetition maximum (1RM)
for the core exercises incorporated in a resistance training program. However, a
major limitation of rigid percent-based training lies in the demanding nature of
directly testing the 1RM from technical, physical, and psychological
perspectives. A potential solution that has gained popularity in the last two
decades to facilitate the implementation of percent-based training involves the
estimation of the 1RM by recording the lifting velocity against submaximal
loads. This review examines the three main methods for prescribing relative
loads (%1RM) based on lifting velocity monitoring: (i) velocity zones,
(ii) generalized load-velocity relationships, and (iii) individualized
load-velocity relationships. The article concludes by discussing a number of
factors that should be considered for simplifying the testing procedures while
maintaining the accuracy of individualized L-V relationships to predict the 1RM
and establish the resultant individualized %1RM-velocity relationship:
(i) exercise selection, (ii) type of velocity variable, (iii) regression model,
(iv) number of loads, (v) location of experimental points on the load-velocity
relationship, (vi) minimal velocity threshold, (vii) provision of velocity
feedback, and (viii) velocity monitoring device.
Timing of Elective Cesarean Section and Neonatal Outcomes in Term Singleton Deliveries: A Single-Center Experience
Authors: Takahashi Daijiro , Fujino Yoshihisa , Sato Tomoki , Kuramoto Akitaka , Kawakami Shoichi , Ito Masaharu , Goto Kei 
Published: August 2023

Objective This study aimed to evaluate the timing of elective cesarean sections at 37 to 41 weeks from a tertiary hospital in Japan. The primary outcome was the rate of adverse neonatal outcomes, especially focusing on neonates delivered at 38 weeks of gestation.
Study Design The study population was drawn from singleton pregnancies delivered following planned cesarean birth at the Fukuda Hospital from 2012 to 2019. Information on deliveries was obtained from the hospital database, which contains clinical, administrative, laboratory, and operating room databases.
Results After excluding women with chronic conditions, maternal complications, indications for multiple births, or a neonate with an anomaly, 2,208 neonates remained in the analysis. Among adverse neonatal outcomes, the rate was significantly higher in neonates delivered at 37 weeks of gestation (unadjusted odds ratio [OR] = 13.22 [95% confidence interval [CI]: 6.28, 27.86], p < 0.001) or 38 weeks of gestation (unadjusted OR = 1.82 [95% CI: 1.04, 3.19], p = 0.036) compared with neonates delivered at 39 to 41 weeks. The adjusted risk of any adverse outcome was significantly higher at 380–1/7 weeks (adjusted OR = 2.40 [95% CI: 1.35, 4.30], p = 0.003) and 382–3/7 weeks (adjusted OR = 1.89 [95% CI: 1.04, 3.44], p = 0.038) compared with neonates delivered at 39 to 41 weeks, respectively.
Conclusion Our findings suggest that elective cesarean sections might be best scheduled at 39 weeks or later. When considering a cesarean at 38 weeks, it appears that 384/7 weeks of gestation or later could be a preferable timing in the context of reducing neonatal risks. However, as the composite outcome includes mostly minor conditions, the clinical significance of this finding needs to be carefully interpreted.
Key Points
Decreasing Antibiotic Use in a Community Neonatal Intensive Care Unit: A Quality Improvement Initiative
Authors: Singh Harjinder P. , Wilkinson Susan , Kamran Shahid 
Published: August 2023

Objective In view of the excessive use of antibiotics in our neonatal intensive care unit (NICU), we launched a 5-year multidisciplinary quality improvement (QI) initiative in our NICU in 2018. We had set our aim of decreasing the antibiotic use rate (AUR) from 22 to 17%.
Study Design The QI initiative was conducted in our 53-bed level 3B NICU. We used the core elements of antibiotic stewardship and focused on improving gaps in knowledge by using updated standards of care and a multidisciplinary approach. Outcome measures included overall AUR in NICU. Statistical control chart (P chart) was used to plot the AUR data quarterly.
Results The AUR demonstrated a decline at the onset, and at the end of the initiative the AUR demonstrated a sustained decline to 13.18%, a 40% decrease from the baseline AUR of 22%. The changes that were implemented included development of evidence-based guidelines for babies less than and greater than 35 weeks, daily antibiotic stewardship rounds, sepsis risk calculator, antibiotic stop orders (48-hour stop, 36-hour soft stop, and 36-hour hard stop), and periodic reviews.
Conclusion Our multidisciplinary approach using all the core elements of an antibiotic stewardship program significantly decreased AUR in our NICU.
Key Points