bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host lifestyle and parasite interspecific facilitation mediate co-infection in a species-poor host-parasite system
Authors: Kmentová Nikol , Cruz-Laufer Armando J. , Milec Leona J. M. , Moons Tanisha , Heeren Senne , van den Hoorn Elze , Thys Kelly J. M. , Makasa Lawrence , Manda Auguste Chocha , Mulungula Pascal Masilya , Van Steenberge Maarten , Jorissen Michiel W. P. , Vanhove Maarten P. M. 
Published: January 2023

AbstractDespite their important ecological role, questions remain on mechanisms structuring parasite assemblages. We present a simple and endemic host-parasite system of clupeid fishes and monogenean parasites (Kapentagyrus, Dactylogyridae) with contrasting levels of host-specificity from Lake Tanganyika as a model to study parasite distribution patterns and co-infection dynamics in nature. With two parasites, two host species, and three host-parasite combinations between them, this unique system represents the simplest natural host-parasite model that is not trivial. We modelled spatiotemporal dynamics of host-parasite interaction using infection data along the North-South axis of Lake Tanganyika (660 km) over the course of two seasons and four years (1730 fish, 3710 parasites). We found temporal stability of infection, which contrasts with previously reported seasonally driven fluctuations of fish host abundances. We found a difference in spatial structure between the parasite species, confirming that their distributions are only restricted by their most mobile host species. On the host species that is infected by two parasite species, we discovered a positive correlation with host body size for one parasite species, and a negative correlation for the other species. As we also discovered facilitation of infection, this cannot be due to competition. The differences reported between parasite species infecting the same host species further extrapolate the dependence on changes in lifestyle of the host during its ontogenetic development. In conclusion, we show that in a simple, closed system parasite infection dynamics are dependent on a combination of host mobility, host lifestyle changes over ontogenetic development and interspecific interactions between parasites.
EVALUATION AND COMPARISON OF THE ANTIOXIDANT AND FREE RADICAL SCAVENGING PROPERTIES OF MEDICINAL PLANTS BY USING THE DPPH ASSAY IN-VITRO
Authors: Yousaf Hassan 
Published: January 2023

DisclaimerThe author(s) have withdrawn their manuscript because it was posted without acknowledging all contributing authors. Therefore, the author(s) do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author:hassanysf98@gmail.com
Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancerous traits and oncogenic pathways shared among bilaterians
Authors: Burioli E.A.V. , Hammel M. , Vignal E. , Vidal-Dupiol J. , Mitta G. , Thomas F. , Bierne N. , Destoumieux-Garzón D. , Charrière G.M. 
Published: January 2023

AbstractTransmissible cancer cell lines are rare biological entities giving rise to diseases at the crossroads of cancer and parasitic diseases. These malignant cells have acquired the amazing capacity to spread from host to host. They have been described only in dogs, Tasmanian devils and marine bivalves. TheMytilus trossulusBivalve Transmissible Neoplasia 2 (MtrBTN2) lineage has even acquired the capacity to spread inter-specifically between marine mussels of theMytilus eduliscomplex worldwide. To identify the oncogenic processes underpinning the biology of these atypical cancers we performed transcriptomics of MtrBTN2 cells. Differential expression, enrichment, protein-protein interaction network, and targeted analyses were used. Overall, our results suggest the accumulation of multiple cancerous traits that way be linked to the long-term evolution of MtrBTN2. We also highlight that vertebrate and lophotrochozoan cancers could share a large panel of common drivers, which supports the hypothesis of an ancient origin of oncogenic processes in bilaterians.
Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage and regeneration response after cisplatin
Authors: Wijaya Lukas S. , Kunnen Steven J. , Trairatphisan Panuwat , Fisher Ciaran , Crosby Meredith E. , Schaefer Kai , Bodie Karen , Vaughan Erin E. , Breidenbach Laura , Reich Thomas , Clausznitzer Diana , Bonnet Sylvestre A. , Zheng Sipeng , Pont Chantal , Stevens James L. , Dévédec Sylvia Le , van de Water Bob 
Published: January 2023

AbstractNephrotoxicity caused by drug or chemical exposure involves different mechanisms and nephron segments as well as a complex temporal integration of injury and repair responses. Distinct cellular transcriptional programs regulate the time-dependent tissue injury and regeneration responses. Whole kidney transcriptome analysis cannot dissect the complex the nephron segment spatio- temporal injury and regeneration responses. Here, we used laser capture microdissection of formalin- fixed paraffin embedded sections followed by whole genome targeted RNA-sequencing-TempO-Seq and co-expression gene-network (module) analysis to determine the spatial-temporal responses in rat kidney glomeruli (GM), cortical proximal tubules (CPT) and outer-medulla proximal tubules (OMPT) comparison with whole kidney, after a single dose of the nephrotoxicant cisplatin. We demonstrate that cisplatin induced early onset of DNA damage in both CPT and OMPT, but not GM. Sustained DNA damage response was strongest in OMPT coinciding with OMPT specific inflammatory signaling, actin cytoskeletal remodeling and increased glycolytic metabolism coincident with suppression of mitochondrial activity. Later responses reflected regeneration-related cell cycle pathway activation and ribosomal biogenesis in the injured OMPT regions. Activation of modules containing kidney injury biomarkers was strongest in the OMPT, with OMPTCluexpression best correlating with urinary clusterin biomarker measurements compared the correlation of Kim1. Our findings also showed that whole kidney responses were less sensitive than OMPT. In conclusion, our LCM-TempO-Seq method reveals a detailed spatial mechanistic understanding of renal injury/regeneration after nephrotoxicant exposure and identifies the most representative mechanism-based nephron segment specific renal injury biomarkers.
Impact of rare structural variant events in newly diagnosed multiple myeloma
Authors: Chojnacka Monika , Diamond Benjamin , Ziccheddu Bachisio , Rustad Even , Maclachlan Kylee , Papadimitriou Marios , Boyle Eileen M. , Blaney Patrick , Usmani Saad , Morgan Gareth , Landgren Ola , Maura Francesco 
Published: January 2023

ABSTRACTWhole genome sequencing (WGS) of newly diagnosed multiple myeloma patients (NDMM) has shown recurrent structural variant (SV) involvement in distinct regions of the genome (i.e. hotspots) and causing recurrent copy number alterations. Together with canonical immunoglobulin translocations, these SVs are recognized as “recurrent SVs”. More than half SVs were not involved in recurrent events. The significance of these “rare SVs” has not been previously examined. In this study, we utilize 752 WGS and 591 RNA-seq data from NDMM patients to determine the role of rare SVs in myeloma pathogenesis. 94% of patients harbored at least one rare SV event. Rare SVs showed an SV-class specific enrichment within genes and superenhancers associated with outlier gene expression. Furthermore, known myeloma driver genes recurrently impacted by point mutations were dysregulated by rare SVs. Overall, we demonstrate the association of rare SVs with aberrant gene expression supporting a driver role in myeloma pathogenesis.SIGNIFICANCECharacterization of multiple myeloma genome revealed that more than half structural variants are not involved in recurrent events. Here, we demonstrate that these rare SVs hold potential for myeloma pathogenesis through their gene expression impact. Rare SVs contribute to MM heterogeneity and have implications for development of individualized treatment.
Establishment of primary renal lymphoma model and the clinical relevance
Authors: Li Xiaoxi , Deng Minyao , Zhang Chenxiao , Luo Lingli , Qian Hui 
Published: January 2023

ABSTRACTExtranodal dissemination was an important feature of aggressive B-cell lymphoma. Due to the lack of available animal model, the causes of extranodal dissemination of lymphoma were largely unknown. Here, we identified a novel cell line, named MA-K, which originated from the Eμ-Myc;Cdkn2a-/-cell line, named MA-LN in this study. Compared to MA-LN, MA-K tended to disseminate in the kidney rather than lymph nodes in lymphoma transplantation model, resembling human primary renal lymphoma. The transcriptome analysis revealed that MA-K had undergone the transcriptional evolution during the culture. Specialized transcriptional pattern analysis, we proposed in this study, identified that FOXO1-BTG1-MYD88 pattern was formed in MA-K. Further analysis found that translation pathway was the most enriched pathway in specially expressed genes (SEGs) in MA-K. Among the SEGs, 3 up-regulated genes, RPLP2, RPS16 and MRPS16, and 5 down-regulated genes, SSPN, CD52, ANKRD37, CCDC82 and VPREB3, in MA-K were identified as promising biomarkers to predict the clinical outcomes of human DLBCL. Moreover, the joint expression of the 5-gene signature could effectively predict clinical outcomes of human DLBCL in triple groups. These findings suggested that the MA-K cell line had strong clinical relevance with human aggressive B-cell lymphoma. Moreover, the MA-K primary renal lymphoma model, as a novel syngenetic mouse model, would be greatly useful for both the basic research on lymphoma dissemination and preclinical efficacy evaluation of chemotherapy and immunotherapy.
EFNB1 level affects drug response in DLBCL cell lines
Authors: Li Xiaoxi , Zhang Chenxiao , Deng Minyao , He Zhengjin , Qian Hui 
Published: January 2023

ABSTRACTTargeted therapy was a promising therapy for aggressive B-cell lymphoma. However, drug resistance was still an unavoidable problem. Here, we explored the effect of EFNB1 on drug response. Analysis of IC50 data showed that high level of EFNB1 was associated with resistance to most targeted drugs targeting BCR in human DLBCL cell lines. Drug response assay showed that Efnb1 could enhance SRC phosphorylation and increased the sensitivity of cells to SRC inhibitors. Meanwhile, Efnb1 could sensitize cells to most cytotoxic drugs, especially DOX and VCR. Efnb1 could confer cells sensitivity to VCR by enhancing the phosphorylation of Stmn1 at serine 28. Survival analysis revealed that the expression level of genes phosphorylated in Efnb1 cells were associated with poor prognosis of human DLBC. Together, this study revealed that EFNB1 level, as a non-genetic mechanism, greatly affected drug response of targeted drugs and cytotoxic drugs through the phosphorylation network. Our findings would provide important insights into EFNB1-SRC activated B-cell lymphoma and efficacy evaluation.
Mindfulness and anti-consumption behavior: the role of authentic living
Authors: Lin Li Min , Park Hyun Jung 
Published: January 2023

PurposeThis study analyzed the relationships among sub-factors of mindfulness and two anti-consumption lifestyles caused by personal and social/environmental concerns. This study also investigated the pursuit of authenticity mediating this relationship.Design/methodology/approachA survey based on self-administered questionnaires and structural equation modeling was used to analyze the collected data via Statistical Product Service Solutions (SPSS) 23 and Analysis of MOment Structure (AMOS) 23. Multiple mediation analysis was adopted to investigate the mediating role of authenticity dimensions via SPSS PROCESS macro.FindingsThe relationship between mindfulness and anti-consumption behavior was generally positive. Except for describing and non-judgment, most facets of mindfulness were positively related to anti-consumption patterns. Only the indirect effect of authentic living (AL) was significant in the impact of mindfulness on anti-consumption behavior.Originality/valueTo the authors' knowledge, this study is the first to examine the link between mindfulness and anti-consumption and potential mechanism of anti-consumption – authenticity seeking, extending knowledge about mindfulness and providing insights for environmentalists, public decision-makers, marketers and consumers.
Configuring optimal contextual performance and task performance in offshore business processing organizations
Authors: Hameed Athar , Khwaja Muddasar Ghani , Zaman Umer 
Published: January 2023

PurposeOccupational stress is damaging to employee well-being, causes serious illnesses and costs organizations billions of dollars every year. Mutual gains model of human resource management (HRM) recommends that HRM practices should improve both employee well-being and performance. Offshore business processing organizations (BPO) are renowned to have intense wok environment. The study aimed to deploy mutual gains models in BPO to determine if positive perceptions of HRM practices (or benevolent HRM attributions) can help employees manage their stress better and improve their task performance (TP) and contextual performance (CP). Furthermore, work gratitude (WG) was examined to see if it acted as an intermediary in the relationship between benevolent HRM attributions, employee stress management (SM), TP and CP.Design/methodology/approachPrimary data of 368 respondents were collected from the employees working in BPO. Structural equation modeling technique was deployed for the testing of causal relationships among constructs. AMOS 24.0 was used for the estimation of theoretical model.FindingsEmpirical outcomes affirmed strongly knitted theoretical associations among the constructs.Originality/valueThis study contributes to literature by proposing a framework which shows how HRM attributions can enhance employee's TP, CP and improve employee SM through the mediating influence of WG.
Quantifying the impact of Russia–Ukraine crisis on food security and trade pattern: evidence from a structural general equilibrium trade model
Authors: Feng Fan , Jia Ningyuan , Lin Faqin 
Published: January 2023

PurposeConsidering the importance of Russia and Ukraine in agriculture, the authors quantify the potential impact of the Russia–Ukraine conflict on food output, trade, prices and food security for the world.Design/methodology/approachThe authors mainly use the quantitative and structural multi-country and multi-sector general equilibrium trade model to analyze the potential impacts of the conflict on the global food trade pattern and security.FindingsFirst, the authors found that the conflict would lead to soaring agricultural prices, decreasing trade volume and severe food insecurity especially for countries that rely heavily on grain imports from Ukraine and Russia, such as Egypt and Turkey. Second, major production countries such as the United States and Canada may even benefit from the conflict. Third, restrictions on upstream energy and fertilizer will amplify the negative effects of food insecurity.Originality/valueThis study analyzed the effect of Russia–Ukraine conflict on global food security based on sector linkages and the quantitative general equilibrium trade framework. With a clearer demonstration of the influence about the inherent mechanism based on fewer parameters compared with traditional Global Trade Analysis Project (GTAP) models, the authors showed integrated impacts of the conflict on food output, trade, prices and welfare across sectors and countries.
Developing a weighted synergy network–based model for selecting prefabricated construction services
Authors: Qi Xiaomin , Du Qiang , Zou Patrick X.W. , Huang Ning 
Published: January 2023

PurposeThe purpose of this paper is to develop a model considering synergy effect for prefabricated construction service combination selection.Design/methodology/approachThis research defines prefabricated construction service as a service-led construction method that meets the specific requirements of clients. Based on network theory, the multi-dimensional collaborative relationships of the prefabricated construction inter-services are formulated. The synergy effect is quantitatively calculated through the linear weighting of the strengths of collaborative relationships. Further, a weighted synergy network (WSN) is developed, from which a service composition selection model considering the synergy effect is established. Then, a genetic algorithm is employed to implement the model.FindingsThe results showed that (1) when the number of prefabricated construction services is increased, the synergy effect of combination options is enhanced; (2) The finer-grained prefabricated construction services, the stronger the synergy effect of service combination; (3) Clients have heterogeneous preferences for collaborative relationships, and there are differences in the synergy effect of service combination.Originality/valueThe contribution of this research includes proposed a method to quantify the synergy effect from the perspective of collaborative relationships, explored the specific procedure for the prefabricated construction service combination selection under the service-led construction, and provided a reference for promoting the development in construction. Besides, the model proposed could be applied to prefabricated construction service composition selection with diverse research boundaries or client preferences by executing the same procedure.
Visualisation of global research trends and future research directions of digital marketing in small and medium enterprises using bibliometric analysis
Authors: Amiri Amiri Mdoe , Kushwaha Bijay Prasad , Singh Rajkumar 
Published: January 2023

PurposeThe purpose of this research is to undertake a bibliometric analysis of digital marketing research in small and medium enterprises (SMEs). The study examines papers over the last two decades and performed performance analysis, co-citation analysis, bibliographic coupling and scientific mapping.Design/methodology/approachThe study examines 247 documents retrieved from the Scopus database using bibliometric analysis, performance analysis and thematic clustering. The study looked at the scientific productivity of papers, prolific authors, most influencing papers, institutions and nations, keyword co-occurrence, thematic mapping, co-citations and authorship and country collaborations. VOSviewer was employed as a tool in the research to conduct the performance analysis and thematic clustering.FindingsThe most productive year was 2021 with 56 publications and the most impactful institute and countries are the University of Birmingham, UK, and the country is United Kingdom, respectively. Similarly, the most influential journal is “Industrial Marketing Management”, and the most productive journal is “International Journal of Internet Marketing and Advertising”. Furthermore, the most cited article is “Usage, barriers and measurement of social media marketing: An exploratory investigation of small and medium B2B brands”. The authors also identified five thematic clusters of digital marketing research in SMEs.Research limitations/implicationsIt informs and directs researchers on the current state of study in the field of digital marketing literature in SMEs. It also outlines future research directions in this field.Originality/valueThis is the first study which provides the performance analysis and scientific mapping of the digital marketing literature in SMEs.
Employee treatment and Securities Exchange Commission investigations
Authors: Brodmann Jennifer , Unsal Omer 
Published: January 2023

PurposeThe authors examine the impact of employee litigation on Securities Action Lawsuits. The authors study whether frequently sued firms are more likely to be investigated by Securities Exchange Commission (SEC). The authors study how labor relations are crucial to corporate governance.Design/methodology/approachThe authors use hand-collected datasets of employee violations, misconducts and lawsuits and test whether bad employee treatment increases the likelihood of SEC probe. The authors' methodology includes panel fixed effects, as well as alternative measures of employee mistreatment and SEC case.FindingsThe authors find that with each increase in employee dispute increases the likelihood of the firm being investigated by the SEC. The authors find that geographically dispersed firms are more likely to be investigated by the SEC when facing employee disputes and that more labor union coverage and a higher unemployment rate triggers more employee allegations and labor-related lawsuits.Originality/valueThe authors' study is the first to investigate how employee relations affect firms involving federal investigation. The authors aim to contribute to the literature by studying (i) the relation between employee mistreatment and legal challenges, (ii) how firm characteristics affect the path from employee disputes to securities class actions and (iii) the impact of employee mistreatment on the corporate governance.
Pre‐stack depth imaging techniques for the delineation of the Carosue Dam gold deposit, Western Australia
Authors: Ziramov Sasha , Young Carl , Kinkela Jai , Turner Greg , Urosevic Milovan 
Published: January 2023

AbstractIn this study, we explore the latest generation of seismic imaging algorithms (migration) that have been successful in the oil and gas exploration industry and apply them in the more challenging hard rock environment. Seismic migration is a crucial processing step required to build an accurate image of the Earth's subsurface. The seismic method applied in a hard rock environment has a specific set of challenges: complex geological settings often comprised of steeply dipping interfaces and heterogeneities (faults, fracture zones, thrusts, etc.); spatially variable zones of alteration, low intrinsic signal‐to‐noise ratio; complex near‐surface conditions (the weathered overburden has a very high contrast in seismic properties with base formations). Here, we present how a dense source–receiver 3D grid in combination with the latest pre‐stack depth imaging techniques can image the geology with a remarkable level of detail and to depths as shallow as the top of fresh rock. We also propose a comprehensive velocity model building strategy applied specifically to the Carosue Dam deposit, Western Australia, which is mainly characterized by volcaniclastic and volcanic rocks within the Carosue Basin disrupted by a complex system of gold‐bearing faults. To arrive at an optimized velocity model for pre‐stack depth imaging, we combine drillhole data with tomographic refinement. Excellent correlation between resultant seismic images and refraction tomography, vertical seismic profiling and drillholes can be attributed to the integrated velocity model building workflow used for depth migration.