bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation and evaluation of a longitudinal diabetes educational programme for adolescents
Authors: Pabedinskas Kristina Loreta , Courtney Jennilea , Barrowman Nicholas , Zankar Sarah , Richardson Christine , Stevens Liz , Goldbloom Ellen B , Lawrence Sarah E , Zuijdwijk Caroline , Lawson Margaret L , Robinson Marie-Eve , Dover Saunya , Ahmet Alexandra 
Published: July 2023

IntroductionInternational guidelines recommendstructured and continuouseducational programmes to expand diabetes knowledge and self-efficacy in youth. To address these recommendations within a paediatric diabetes clinic, we conducted a three-phase quality improvement project aimed at improving adolescents’ confidence in diabetes self-management skills.MethodsIn phase 1, the Diabetes Learning Centre (DLC), an educational programme for adolescents with type 1 diabetes (T1D) ages 13–17 years, was developed and implemented. Programme feasibility was evaluated through programme attendance rates. Phase 2 aimed to guide ongoing programme development and optimisation. DLC attendees rated their baseline confidence in overall and individual T1D self-management skills on a 5-point Likert scale. Patient characteristics were summarised using descriptive statistics and the association between patient characteristics and overall confidence in T1D self-management was evaluated. Phase 3 used patient surveys to evaluate patient satisfaction and reported change in confidence in self-management skills following DLC attendance.ResultsIn phase 1, 232 (81%) of eligible adolescents attended the DLC during the study period. In phase 2, median overall confidence in diabetes management on a Likert scale (0–4) was 3, representing ‘quite confident’, although confidence was low in some essential self-management skills. Higher confidence was associated with lower HbA1c (p<0.001). In phase 3, 77 (85%) of participants reported high levels of satisfaction with the DLC. 106 (82%) of completed worksheets were associated with improved confidence in the diabetes self-management skill addressed.ConclusionsImplementation of a longitudinal T1D educational model was feasible with good uptake in an existing T1D programme. While confidence at baseline was quite high for overall T1D self-management, it was low in some essential self-management skills, highlighting the need for this programme and specific educational gaps. Adolescents reported improvements in confidence and high levels of satisfaction following DLC attendance. Our model provides a replicable programme template to address longitudinal education needs.
Development and validation of an intervention package to improve lifejacket wear for drowning prevention among occupational boaters on Lake Albert, Uganda
Authors: Oporia Frederick , Nuwaha Fred , Kobusingye Olive , Jagnoor Jagnoor , Makumbi Fredrick Edward , Isunju John Bosco , Kibira Simon P S 
Published: July 2023

BackgroundOccupational drowning is a growing public health concern globally. The human cost of fishing is highest in sub-Saharan Africa. Although lifejackets prevent drowning, the majority of boaters in Uganda do not wear them. We developed and validated a peer-to-peer training manual to improve lifejacket wear among occupational boaters on Lake Albert, Uganda.MethodsThe intervention was developed in three stages. In stage one, we conducted baseline studies to explore and identify aspects of practices that need to change. In stage two, we held a stakeholder workshop to identify relevant interventions following the intervention functions of the behaviour change wheel (BCW). In stage three, we developed the content and identified its implementation strategies. We validated the intervention package using the Content Validity Index for each item (I-CVI) and scale (S-CVI/Ave).ResultsSeven interventions were identified and proposed by stakeholders. Training and sensitisation by peers were unanimously preferred. The lowest I-CVI for the content was 86%, with an S-CVI/Ave of 98%. This indicates that the intervention package was highly relevant to the target community.ConclusionThe stakeholder workshop enabled a participatory approach to identify the most appropriate intervention. All the proposed interventions fell under one of the intervention functions of the BCW. The intervention should be evaluated for its effectiveness in improving lifejacket wear among occupational boaters.
Patient-level factors predictive of interstitial lung disease in rheumatoid arthritis: a systematic review
Authors: Matteson Eric L. , Matucci-Cerinic Marco , Kreuter Michael , Burmester Gerd R , Dieudé Philippe , Emery Paul , Allanore Yannick , Pope Janet , Khanna Dinesh 
Published: July 2023

ObjectiveInterstitial lung disease (ILD) is an important cause of mortality in some patients with rheumatoid arthritis (RA). Patient-level factors may predict which patients with RA are at the highest risk of developing ILD and are therefore candidates for screening for this complication of the underlying disease.MethodsA systematic literature review was performed using PubMed, Embase and Scopus over a 10-year period up to July 2021. Publications reporting patient-level factors in patients with RA with and without ILD that were assessed before development of ILD (or were unchanged over time and therefore could be extrapolated to before development of ILD) were retrieved for assessment of evidence. Genetic variation inMUC5Band treatment with methotrexate were not included in the assessment of evidence because these factors have already been widely investigated for association with ILD.ResultsWe found consistent associations of age, sex, smoking status and autoantibodies with development of ILD. For biomarkers such as Krebs von den Lungen 6, which have been shown to be diagnostic for ILD, there were no publications meeting criteria for this study.ConclusionsThis analysis provides an initial step in the identification of patient-level factors for potential development of a risk algorithm to identify patients with RA who may be candidates for screening for ILD. The findings represent a useful basis for future research leading to an improved understanding of the disease course and improved care for patients with RA at risk of development and progression of ILD.
Anti-topoisomerase, but not anti-centromere B cell responses in systemic sclerosis display active, Ig-secreting cells associated with lung fibrosis
Authors: Wortel Corrie M , Liem Sophie IE , van Leeuwen Nina M , Boonstra Maaike , Fehres Cynthia M , Stöger Lauran , Huizinga Tom WJ , Toes René EM , De Vries-Bouwstra Jeska , Scherer Hans U 
Published: July 2023

ObjectivesAlmost all patients with systemic sclerosis (SSc) harbour autoantibodies. Anti-topoisomerase antibodies (ATA) and anti-centromere antibodies (ACA) are most prevalent and associate with distinct clinical phenotypes. B cell responses underlying these phenotypes are ill-defined. To understand how B cell autoreactivity and disease pathology connect, we determined phenotypic and functional characteristics of autoreactive B cells in ATA-positive and ACA-positive patients.MethodsLevels and isotypes of autoantibodies secreted by ex vivo cultured peripheral blood mononuclear cells from patients with ATA-positive (n=22) and ACA-positive (n=20) SSc were determined. Antibody secreting cells (ASCs) were isolated by cell sorting and cultured separately. Correlations were studied between the degree of spontaneous autoantibody production and the presence and degree of interstitial lung disease (ILD).ResultsCirculating B cells secreting either ATA-immunoglobulin G (IgG) or ACA-IgG on stimulation was readily detectable in patients. The ATA response, but not the ACA response, showed additional secretion of autoreactive IgA. ATA-IgG and ATA-IgA were also secreted spontaneously. Additional cell sorting confirmed the presence of ATA-secreting plasmablasts. The degree of spontaneous ATA-secretion was higher in patients with ILD than in those without (p<0.001) and correlated with the degree of pulmonary fibrosis (p<0.001).ConclusionIn contrast to ACA-positive patients, ATA-positive patients show signs of recent activation of the B cell response that hallmarks this disease. The degree of activation correlates with the presence and severity of ILD, the most deleterious disease manifestation. This could explain differential responsiveness to B cell depleting therapy. The abundant and spontaneous secretion of ATA-IgG and ATA-IgA may point toward a continuously activating trigger.
The 2023 pipeline of disease-modifying antirheumatic drugs (DMARDs) in clinical development for spondyloarthritis (including psoriatic arthritis): a systematic review of trials
Authors: Denis Agathe , Sztejkowski Cédric , Arnaud Laurent , Becker Guillaume , Felten Renaud 
Published: July 2023

ObjectivesThe objective of this systematic review was to provide an overview of current developments and potentially available therapeutic options for spondyloarthritis (SpA) in the coming years.MethodsWe conducted a systematic review of 17 national and international clinical trial databases for all disease-modifying antirheumatic drugs (DMARDs) for SpA that are already marketed, in clinical development or withdrawn. The search was performed on February 2023 with the keywords “spondyloarthritis”, “ankylosing spondylitis” and “psoriatic arthritis”. For each molecule, we only considered the study at the most advanced stage of clinical development.ResultsConcerning axial SpA (axSpA), a total of 44 DMARDs were identified: 6 conventional synthetic DMARDs (csDMARDs), 27 biological DMARDs (bDMARDs) and 11 targeted synthetic DMARDs (tsDMARDs). Among the 18 targeted treatments (b+tsDMARDs) in current development, corresponding trials reached phase I (n=1), II (n=10) and III (n=7). Ten molecules are IL-17 inhibitors, two Janus kinase (JAK) inhibitors and two granulocyte-macrophage colony-stimulating factor inhibitors; four have another mode of action. Concerning psoriatic arthritis (PsA), 44 DMARDs were identified: 5 csDMARDs, 27 bDMARDs and 12 tsDMARDs. Among the 15 molecules in current development, corresponding trials reached phase II (n=8) and III (n=7). Six molecules are JAK inhibitors, six IL-17 inhibitors and one an IL-23 inhibitor; two have another mode of action.ConclusionThis systematic review identified 18 and 15 molecules in clinical development for axSpA and PsA, respectively, which suggests a strengthening of the therapeutic arsenal in the coming years. However, with so many DMARDs but low target diversity, we will need to develop strategies or biomarkers to help clinicians make informed treatment decisions.
A Mendelian randomisation, propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm
Authors: Wen Zhuohua , Feng Xin , Tong Xin , Peng Chao , Xu Anqi , Fan Haiyan , Bi Yiming , Liu Wenchao , Li Zhenjun , Guo Shenquan , Jin Fa , Li Ran , Liu Yanchao , Su Shixing , Zhang Xin , Li Xifeng , He Xuying , Liu Aihua , Duan Chuanzhi 
Published: July 2023

Background and purpose
Recent observational studies have reported that serum total homocysteine (tHcy) is associated with intracranial aneurysms (IAs). However, the causal effect of tHcy on IAs is unknown. We leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA formation.

Methods
We performed a two-sample Mendelian randomisation (MR) using publicly available genome-wide association studies summary statistics to investigate the causal relationship between tHcy and IAs, following the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology-MR statement. Furthermore, a propensity score matching (PSM) analysis was conducted to evaluate the detailed effects of tHcy on risk of IA formation by utilizing real-world multicentre data, including 9902 patients with and without IAs (1:1 matched). Further interaction and subgroup analyses were performed to elucidate how tHcy affects risk of IA formation.

Results
MR analyses indicated that genetically determined tHcy was causally associated with IA risk (OR, 1.38, 95% CI 1.07 to 1.79; p=0.018). This is consistent with the more conservative weighted median analysis (OR, 1.41, 95% CI 1.03 to 1.93; p=0.039). Further sensitivity analyses showed no evidence of horizontal pleiotropy or heterogeneity of single nucleotide polymorphisms in causal inference. According to the PSM study, we found that, compared with low tHcy (≤15 µmol/L), moderate tHcy (>15–30 µmol/L) (OR 2.13, 95% CI 1.93 to 2.36) and high tHcy (>30 µmol/L) (OR 3.66, 95% CI 2.71 to 4.95) were associated with a higher IA risk (p trend <0.001). Subgroup analyses demonstrated significant ORs of tHcy in each subgroup when stratified by traditional cardiovascular risk factors. Furthermore, there was also a synergistic effect of tHcy and hypertension on IA risk (p interaction <0.001; the relative excess risk due to interaction=1.65, 95% CI 1.29 to 2.01).

Conclusion
Both large-scale genetic evidence and multicentre real-world data support a causal association between tHcy and risk of IA formation. Serum tHcy may serve as a biomarker to identify high-risk individuals who would particularly benefit from folate supplementation.
Learning trivializing flows
Authors: Albandea D. , Del Debbio L. , Hernández P. , Kenway R. , MarshRossney J. , Ramos A. 
Published: July 2023

AbstractThe recent introduction of machine learning techniques, especially normalizing flows, for the sampling of lattice gauge theories has shed some hope on improving the sampling efficiency of the traditional hybrid Monte Carlo (HMC) algorithm. In this work we study a modified HMC algorithm that draws on the seminal work on trivializing flows by Lüscher. Autocorrelations are reduced by sampling from a simpler action that is related to the original action by an invertible mapping realised through Normalizing Flows models with a minimal set of training parameters. We test the algorithm in a$$\phi ^{4}$$ϕ4theory in 2D where we observe reduced autocorrelation times compared with HMC, and demonstrate that the training can be done at small unphysical volumes and used in physical conditions. We also study the scaling of the algorithm towards the continuum limit under various assumptions on the network architecture.
Tests of the parametrizations of fragmentation functions using data on inclusive pion and kaon production in unpolarized pp collisions from the STAR collaboration and at the NICA project
Authors: Kotlorz D. , Christova E. , Leader E. 
Published: July 2023

The goal of this study is to check which, if any, of the published versions of the pion and kaon fragmentation functions (FFs) is compatible with the STAR data on semi-inclusive pion and kaon production in proton–proton collisions, and on the basis of this analysis to make reliable predictions for the [Formula: see text] spectra of the pions and kaons in inclusive pion and kaon production at the future NICA proton–proton collider. The calculations are carried out in next-to-leading order (NLO) of perturbative quantum chromodynamics (pQCD), using the well-tested CTEQ6 parton distributions. We consider the following pion and kaon FFs — DSEHS-14 [D. de Florian, R. Sassot, M. Epele, R. J. Hernández-Pinto and M. Stratmann, Phys. Rev. D 91, 014035 (2015), 1410.6027], DSEHS-17 [D. de Florian, M. Epele, R. J. Hernandez-Pinto, R. Sassot and M. Stratmann, Phys. Rev. D 95, 094019 (2017), 1702.06353], LSS-15 [E. Leader, A. V. Sidorov and D. B. Stamenov, Phys. Rev. D 93, 074026 (2016), 1506.06381], HKNS-07 [M. Hirai, S. Kumano, T. H. Nagai and K. Sudoh, Phys. Rev. D 75, 094009 (2007), hep-ph/0702250] and AKK-08 [S. Albino, B. A. Kniehl and G. Kramer, Nucl. Phys. B 803, 42 (2008), 0803.2768]. Our analysis shows that within the experimental errors all tested sets of FFs provide a good fit to STAR data at the c.m. energy [Formula: see text], and the best ones are both LSS-15 and DSEHS-14 for pions and DSEHS-17 for kaons. From comparison of the LO and NLO results it is clear that the latter fit data much better, specially in the region of small [Formula: see text]. The NLO cross-sections are also less scale-[Formula: see text] dependent, where [Formula: see text], than the LO ones. In order to make predictions for NICA energies, we compare the NLO pQCD results with the existing experimental BES STAR data on semi-inclusive hadron production in the most peripheral Au+Au collisions where the nuclear effects can be neglected. The comparison for lower energy scales, like at NICA, shows that a purely pQCD approach is inadequate and suggests the necessity to take into account also higher-order effects of initial-state soft-gluon radiation. Nevertheless, these data on the [Formula: see text] spectra of [Formula: see text], [Formula: see text] and also the ratios [Formula: see text] and [Formula: see text] seem to favor LSS-15 and DSEHS-14 FFs for pions and DSEHS-17 for kaons, similarly as at the energy scale [Formula: see text][Formula: see text]GeV.
Application of Artificial Neural Network Unified with Fuzzy Logic for Systematic Stock Market Prediction
Authors: Kumar Akhilesh , Keshta Ismail , Bhola Jyoti , Wasim Bhatt Mohammed , AlQahtani Salman A. , Gali Manvitha 
Published: July 2023

Prediction of the stock market can play a vital role in everyone’s life to attain sustainable growth. This can also lead to an attractive profit by making the proper choices in the financial stock market. The stock market prediction is a big challenge which requires extensive advanced tools and techniques to analyze the future and present data. The modern stock market institutions provide better self-trading and investment options, enabling regular people and traders to enter the market through numerous online applications and websites that are available via smart devices. Financial institutions are investing more and more in talent development so that investors may make the maximum money. There are a multitude of reasons for this, including volatility of market and a collection of other interrelated and independent parameters that control the market value of a different stock. Because of these factors, it is excessively difficult for any specialist in financial markets to accurately predict the market’s rise and collapse. This research paper proposed an artificial neural network (ANN) technique which combines with fuzzy logic to predict the stock market for short duration with high accuracy. First, historical and real-time data are used to classify and gather information for prediction. Then the short-duration prediction is done with a high accuracy of 96% and the error margin for a small instance is 2.3%. Through training, testing and validation it is clear that for sustainable short duration prediction, ANN integrated with fuzzy is a good choice.
Conformally invariant nonlinear electrodynamic actions and its non-abelian extensions
Authors: Cirilo-Lombardo Diego Julio 
Published: July 2023

In this work, formal theoretical aspects concerning conformally invariant functional actions of electrodynamics are presented and discussed. In particular, the origin of the conformal and duality invariant Lagrangians of [I. Bandos et al., J. High Energy Phys. 10 (2021) 031; I. Bandos, K. Lechner, D. Sorokin and P. Townsend, Phys. Rev. D 102 (2020) 121703] (e.g. ModMax) and also Born–Infeld types are analyzed being its non-abelian counterpart presented and discussed explicitly for the gauge group SU(2). Implications on the properties of the gravitational field are briefly discussed by means of new symmetries of the field equations.
Stability of an (A,Q)-functional equation in a Banach space
Authors: Park Choonkil , Senasukh Jedsada 
Published: July 2023

In this paper, we study an [Formula: see text]-functional equation [Formula: see text] in a Banach space and determine its general solutions (in certain groups). Moreover, we verify some stability results of the [Formula: see text]-functional equation as a consequence of a fixed point theorem in a complete metric space investigated by Brzdȩk et al. [A fixed point approach to stability of functional equations, Nonlinear Anal. 74 (2011) 6728–6732].
Immediate Proximal Row Carpectomy for Severe Perilunate Dislocation Injuries: A Minimum 5-Year Follow-Up
Authors: TOMCZAK Sacha , ABELLAN LOPEZ Maxime , JALOUX Charlotte , LEGRE Regis , BERTRAND Baptiste , DE VILLENEUVE BARGEMON Jean-Baptiste 
Published: July 2023

Background: In patients with perilunate injuries (PLI) with multiple ligamentous and bony injuries involving the proximal carpal row, open reduction and internal fixation (ORIF) can be difficult and lead to poor functional outcomes. Proximal row carpectomy (PRC) is an alternative procedure that has been used for severely comminuted fractures. The aim of our study is to evaluate the long-term functional outcome (minimum 5 years) of patients that underwent an emergency PRC for PLI. Methods: We conducted a retrospective study of patients who underwent PRC at our centre between 2001 and 2016. Only patients with follow-up data of more than 5 years were included in the study. We evaluated range of motion, grip strength, Mayo Modified Wrist Score (MMWS) and Quick Disabilities of Arm, Shoulder and Hand (Quick-DASH). Radiographic analyses were performed to assess the presence of radiocarpal osteoarthritis and the space between the radius and capitate. Results: Thirteen patients were included, with an average follow-up of 78.07 months (6.5 years). The MMWS was 65 points (four excellent and good, four fair and five poor results) and the Quick-DASH score was 30 points. X-ray analysis reported only 15.3% of patients with radiocarpal arthrosis and an average radio-capitate joint space of 1.92 mm. Conclusions: The outcomes of PRC in the management of PLI are comparable to the results reported in literature for conventional ORIF. PRC is a simpler procedure that minimises the need for re-intervention. Level of Evidence: Level IV (Therapeutic)
Unfortunate Fall: Ethiopianism and Theodicy in Early Nineteenth-Century African American Thought
Authors: Andersen Nicholas P. 
Published: July 2023

Abstract
Many scholars of African American and Africana religions have argued that Ethiopianism provided a fertile vocabulary for making sense of Black suffering. Linking Ethiopianism especially to the prophetic genre of theodicy, this article contends that it also provided a narrative framework within which nineteenth-century African Americans imagined and enacted novel forms of race-making and peoplehood. To this end, it offers readings of theodicy in the work of David Walker and Maria Stewart. In different ways, their uses of theodicy called into existence a global African community, whose boundaries exceeded the temporal and geographical parameters of the US and the Americas and whose agency was invested with God-given significance, such that, if exercised properly, Africans could work to redeem themselves from the horrors of the modern/colonial world.