bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compartment Syndrome after Crotalid Envenomation in the United States: A Review of the North American Snakebite Registry from 2013 to 2021 on Behalf of the ToxIC Snakebite Study Group
Authors: Spyres Meghan B. , Maker Greg , Aldy Kim , Wolk Brian J. , Meadors Kevan E. , Christian Michael , Ruha Anne-Michelle 
Published: July 2023

Introduction Compartment syndrome (CS) is a rare but serious complication after crotalid envenomation in the United States. Few data are available regarding the epidemiology and management of these cases. Significant controversy and misunderstanding over best practices, including measurement of compartment pressures and use of fasciotomy, exist for this syndrome. This study aims to describe presentation and management of suspected CS cases after native snakebite reported to the North American Snakebite Registry (NASBR). Methods This is an analysis of snakebite cases reported to the Toxicology Investigators Consortium NASBR between January 1, 2013 and December 31, 2021. Cases of native snakebite with documented concern for CS were included. Results Over an 8-y period, 22 cases of suspected CS were identified, representing 1% of all cases reported to the NASBR. Fasciotomies were performed in 41% (n=9) of these cases, most commonly to the upper extremity (67%, n=6). In cases of suspected CS, intracompartmental pressures (ICPs) were rarely measured (23%, n=5) and fasciotomies were performed without measurement of ICPs frequently (56%, n=5). In 1 case, ICPs were measured and found to be low (8 mm Hg) and fasciotomy was avoided. Conclusions Measurement of compartment pressures in cases of suspected CS was uncommon in cases reported to the NASBR. Fasciotomy was commonly performed without measurement of compartment pressures.
Contaminated water and the Food Safety Modernization Act
Authors: Bahalou Horeh Marziyeh , Elbakidze Levan , Taylor R. Garth 
Published: July 2023

AbstractWe develop a theoretical framework and present a corresponding empirical analysis of the Food and Drug Administration’s irrigation water quality regulatory standard under the Food Safety Modernization Act using lettuce as a case study. We develop a stochastic price endogenous partial equilibrium model with recourse to examine the standard’s efficacy under various scenarios of foodborne illness severity, standard implementation, demand response to foodborne outbreaks, and irrigation costs. The stringency of regulation is evaluated with endogenous producer response to regulatory requirements and corresponding implications for economic surplus. The baseline results show that in the case of the lettuce market, the proposed microbial irrigation water quality regulation in the Food Safety Modernization Act (FSMA) is not cost effective relative to the existing Leafy-Greens Marketing Agreements relying on water treatment for mitigation of microbial contamination. However, FSMA can be cost effective if water treatment is sufficiently expensive.
Exploring potential mental health spillover effects among caregivers and partners of youth in Sierra Leone: A qualitative study
Authors: Desrosiers Alethea , Schafer Carolyn , Bond Laura , Akinsulure-Smith Adeyinka , Hinton Miriam , Vandi Alpha , Betancourt Theresa S. 
Published: July 2023

Abstract
Given the large mental health treatment gap in low- and middle-income countries (LMICs), particularly in post-conflict settings like Sierra Leone, and the limited healthcare infrastructure, understanding the wider benefits of evidence-based mental health interventions within households is critical. This study explored potential mental health spillover effects – the phenomenon of beneficial effects among nonparticipants – among cohabitating caregivers and partners of youth who participated in an evidence-based mental health intervention in Sierra Leone. We recruited a sub-sample of cohabitating caregivers and partners (N = 20) of youth intervention participants; caregivers had enrolled in a larger study investigating indirect benefits of the evidence-based intervention in Sierra Leone (MH117359). Qualitative interviews were conducted at two time points to explore the following: (a) potential mental health spillover effects and (b) through which mechanisms spillover may have occurred. Two trained coders reviewed transcripts and analyzed qualitative data, assisted by MaxQDA. Qualitative findings suggested that spillover effects likely occurred and supported three potential mechanisms: decreased caregiving burden, behavior changes among Youth Readiness Intervention participants and improved interpersonal relationships. Mental health spillover effects may occur following youth intervention participation in a post-conflict LMIC. Investing in evidence-based services may offer indirect benefits that extend beyond those directly receiving services.
Fārsīgraphy in Zoroastrian Middle Persian Manuscripts
Authors: Šafiʿī Ibrāhīm 
Published: July 2023

Abstract
The tradition of writing in Iran has a long history, and its continuous development has, from time to time, led to new scripts. A most notable case is that of Perso-Arabic's replacement of Pahlavi script when New Persian replaced Middle Persian, resulting in Zoroastrian priests having difficulties reading and understanding their religious texts. The process of changing scripts is well attested by the tradition of Pāzand. Although Pāzand was considered one of the first types of transliteration in Iran, this tradition was also gradually abandoned due to its reliance on Avestan script, which was and continues to be uncommon. Avestan script is now found in Zoroastrian Middle Persian (Pahlavi) manuscripts, just as Pāzand was traditionally used for earlier texts. Pāzand–i.e., transcription of Middle Persian in the Avestan alphabet–was used for some time, but was eventually abandoned for scripts in common use, i.e., Persian in Persia and Gujarati and Devanagari in India. In this paper, the aim is to identify and categorize this tradition's characteristics in Pahlavi manuscripts, drawing on manuscripts from the fifty-three volumes published by the Asia Institute of the Pahlavi University of Shiraz, as listed in the Appendix.
A tale of two histories: Dual-system architectures in modular perspective
Authors: Zerilli John 
Published: July 2023

AbstractI draw parallels and contrasts between dual-system and modular approaches to cognition, the latter standing to inherit the same problems De Neys identifies regarding the former. Despite these two literatures rarely coming into contact, I provide one example of how he might gain theoretical leverage on the details of his “non-exclusivity” claim by paying closer attention to the modularity debate.
Not feeling right about uncertainty monitoring
Authors: Newman Ian R. , Thompson Valerie A. 
Published: July 2023

Abstract
De Neys proposed a “switch” model to address what he argued to be lacuna in dual-process theory, in which he theorized about the processes that initiate and terminate analytic thinking. We will argue that the author neglected to acknowledge the abundant literature on metacognitive functions, specifically, the meta-reasoning framework developed by Ackerman and Thompson (2017), that addresses just those questions.
Describe the house and I will tell you the price: House price prediction with textual description data
Authors: Zhang Hanxiang , Li Yansong , Branco Paula 
Published: July 2023

AbstractHouse price prediction is an important problem that could benefit home buyers and sellers. Traditional models for house price prediction use numerical attributes such as the number of rooms but disregard the house description text. The recent developments in text processing suggest these can be valuable attributes, which motivated us to use house descriptions. This paper focuses on the house asking/advertising price and studies the impact of using house description texts to predict the final house price. To achieve this, we collected a large and diverse set of attributes on house postings, including the house advertising price. Then, we compare the performance of three scenarios: using only the house description, only numeric attributes, or both. We processed the description text through three word embedding techniques: TF-IDF, Word2Vec, and BERT. Four regression algorithms are trained using only textual data, non-textual data, or both. Our results show that by using exclusively the description data with Word2Vec and a Deep Learning model, we can achieve good performance. However, the best overall performance is obtained when using both textual and non-textual features. An$R^2$of 0.7904 is achieved by the deep learning model using only description data on the testing data. This clearly indicates that using the house description text alone is a strong predictor for the house price. However, when observing the RMSE on the test data, the best model was gradient boosting using both numeric and description data. Overall, we observe that combining the textual and non-textual features improves the learned model and provides performance benefits when compared against using only one of the feature types. We also provide a freely available application for house price prediction, which is solely based on a house text description and uses our final developed model with Word2Vec and Deep Learning to predict the house price.
Widespread Permafrost Degradation and Thaw Subsidence in Northwest Canada
Authors: O’Neill H. B. , Smith S. L. , Burn C. R. , Duchesne C. , Zhang Y. 
Published: July 2023

AbstractLong‐term (1991–2018) thaw tube measurements highlight widespread permafrost thaw and ground surface (GS) subsidence over a large portion of northwest Canada. Statistically significant positive trends in thaw penetration (TP), measured with respect to a fixed datum, were observed at 18 of 28 sites with data that span three decades at a median rate of 0.8 cm a−1. This rate implies thawing of about 22 cm of permafrost over the study period. Similarly significant trends in GS subsidence occurred at 21 of 28 sites, at a median rate of 0.4 cm a−1. In contrast with TP and GS elevation, long‐term trends in active layer thickness (ALT) were less consistent, with 10 of 28 sites having statistically significant trends indicating increasing ALT (median rate: 0.6 cm a−1), and 7 sites having trends indicating decrease in ALT (median: 0.3 cm a−1). The ALT measurements underestimated the thawing of ice‐rich permafrost due to GS subsidence. Sites with high rates of thaw had relatively warm permafrost, deep snow cover, and poor drainage. Masking of ice‐rich permafrost degradation by ALT measurements has important implications for modeling permafrost thaw and climate change reporting. Accurate simulation of ice‐rich permafrost thaw is conceivable for sites where conditions are well‐defined. However, the prediction of subsidence and TP at regional or broader scales is only possible in general terms due to variation in surface conditions and ground ice content. Trends in TP and GS subsidence more accurately characterize ice‐rich permafrost degradation than trends in ALT.
Nitrate Legacy in a Tropical and Complex Fractured Volcanic Aquifer System
Authors: Sánchez‐Gutiérrez R. , Sánchez‐Murillo R. , Esquivel‐Hernández G. , Birkel C. , Boll J. , Rojas‐Jiménez L. D. , Castro‐Chacón L. 
Published: July 2023

AbstractNitrate legacy is affecting groundwater sources across the tropics. This study describes isotopic and ionic spatial trends across a tropical, fractured, volcanic multi‐aquifer system in central Costa Rica in relation to land use change over four decades. Springs and wells (from 800 to 2,400 m asl) were sampled for NO3− and Cl− concentrations, δ18Owater, δ15NNO3, and δ18ONO3. A Bayesian isotope mixing model was used to estimate potential source contributions to the nitrate legacy in groundwater. Land use change was evaluated using satellite imagery from 1979 to 2019. The lower nitrate concentrations (<1 mg/L NO3−N) were reported in headwater springs near protected forested areas, while greater concentrations (up to ∼63 mg/L) were reported in wells (mid‐ and low‐elevation sites in the unconfined unit) and low‐elevation springs. High‐elevation springs were characterized by low Cl− and moderate NO3−/Cl− ratios, indicating the potential influence of soil nitrogen (SN) inputs. Wells and low‐elevation springs exhibited greater NO3−/Cl− ratios and Cl− concentrations above 100 μmol/L. Bayesian calculations suggest a mixture of sewage (domestic septic tanks), SN (forested recharge areas), and chemical fertilizers (coffee plantations), as a direct result of abrupt land use change in the last 40 years. Our results confirm the incipient trend in increasing groundwater nitrogen and highlight the urgent need for a multi‐municipal plan to transition from domestic septic tanks to regional sewage treatment and sustainable agricultural practices to prevent future groundwater quality degradation effectively.
Dual intron-targeted CRISPR-Cas9-mediated disruption of the AML RUNX1-RUNX1T1 fusion gene effectively inhibits proliferation and decreases tumor volume in vitro and in vivo
Authors: Neldeborg Signe , Soerensen Johannes Frasez , Møller Charlotte Thornild , Bill Marie , Gao Zongliang , Bak Rasmus O. , Holm Kasper , Sorensen Boe , Nyegaard Mette , Luo Yonglun , Hokland Peter , Stougaard Magnus , Ludvigsen Maja , Holm Christian Kanstrup 
Published: July 2023

AbstractOncogenic fusion drivers are common in hematological cancers and are thus relevant targets of future CRISPR-Cas9-based treatment strategies. However, breakpoint-location variation in patients pose a challenge to traditional breakpoint-targeting CRISPR-Cas9-mediated disruption strategies. Here we present a new dual intron-targeting CRISPR-Cas9 treatment strategy, for targeting t(8;21) found in 5–10% of de novo acute myeloid leukemia (AML), which efficiently disrupts fusion genes without prior identification of breakpoint location. We show in vitro growth rate and proliferation reduction by 69 and 94% in AML t(8;21) Kasumi-1 cells, following dual intron-targeted disruption of RUNX1-RUNX1T1 compared to a non t(8;21) AML control. Furthermore, mice injected with RUNX1-RUNX1T1-disrupted Kasumi-1 cells had in vivo tumor growth reduction by 69 and 91% compared to controls. Demonstrating the feasibility of RUNX1-RUNX1T1 disruption, these findings were substantiated in isolated primary cells from a patient diagnosed with AML t(8;21). In conclusion, we demonstrate proof-of-principle of a dual intron-targeting CRISPR-Cas9 treatment strategy in AML t(8;21) without need for precise knowledge of the breakpoint location.
The effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients: a randomized controlled trial
Authors: Zhou Youfa , Wang Cencen , Lin Binbin , Lin Xianyi , Zhang Yanting , Yu Xin , Chen Gang 
Published: July 2023

AbstractSerotonin 3 receptor antagonists, a commonly used drug for preventing postoperative nausea and vomiting, have recently been reported to decrease the incidence of hypotension and the need for vasoactive drugs after spinal anaesthesia in obstetric surgery. However, it remains unknown whether they could also prevent hypotension after induction of general anaesthesia. In the current study, we aimed to investigate the effect of intravenous granisetron on prophylactic ephedrine for preventing hypotension after general anaesthesia induction in elderly patients. Sixty elderly patients were randomly assigned to receive granisetron or saline control 30 min before induction of general anaesthesia. The first patient in each group received a prophylactic dose of ephedrine (0.15 mg kg−1) to prevent hypotension. The prophylactic dose for each patient was increased or decreased by 0.05 mg/kg based on the efficacy results of the previous patient. The up-down sequential allocation analysis and probit regression was used to calculate the effective dose for 50% of patients (ED50) with prophylactic ephedrine. In the up-down sequential allocation analysis, the ED50 of ephedrine was significantly lower in group granisetron (0.08 mg kg−1 [95% CI, 0.06–0.11 mg kg−1]) when compared with group control (0.14 mg kg−1 [95% CI, 0.13–0.16 mg kg−1]) (P < 0.001). The conclusion was further supported by probit regression analysis (0.09 mg kg−1 [95% CI, 0.05–0.12 mg kg−1] in group granisetron and 0.14 mg kg−1 [95% CI, 0.12–0.16 mg kg−1] in group control). Intravenous granisetron reduced the requirement of prophylactic ephedrine in preventing hypotension after general anaesthesia induction in elderly patients.
Seasonal variations of triterpene acid contents in Viscum album L. on typical host trees of Hyrcanian forests
Authors: Soursouri Arina , Hosseini Seyed Mohsen , Fattahi Farnoosh 
Published: July 2023

AbstractViscum albumL. (mistletoe) is a semiparasitic plant of the Santalaceae family. A valuable group of bioactive compounds in mistletoe are triterpene acids (TTAs), which possess anti-inflammatory and anticancer properties.Parrotia persicaandCarpinus betulusare the most common hosts of mistletoe in the Hyrcanian forests of Iran. This study was performed to compare the content of oleanolic acid (OA), betulinic acid (BA), and ursolic acid (UA) in the mistletoe foliage (stems and leaves) fromP. persicaandC. betulusin various seasons for the first time. The results showed that OA was the prevailing TTA in all samples, while UA was found in none of them. The maximum amount of OA (12.38 mg/g dry weight [DW]) and BA (1.68 mg/g DW) was detected inV. albumfromP. persicain summer. The minimum amount of OA (5.58 mg/g DW) and BA (0.72 mg/g DW) was observed in that growing onC. betulusin winter. However, the mistletoe fromC. betulusshowed the greatest level of OA in spring (9.06 mg/g DW) and BA in summer and autumn (0.92 and 0.97 mg/g DW, respectively). The data collected in this study complement existing research on this subject from around the world.
Sleeping behavior and associated factors during COVID-19 in students at a Hispanic serving institution in the US southwestern border region
Authors: Rahman Humairat H. , Akinjobi Zainab , Gard Charlotte , Munson-McGee Stuart H. 
Published: July 2023

AbstractSleep is responsible for maintenance and regulatory functions in human physiology. Insufficient sleep has been associated with cardiovascular disease, weight gain, obesity, inflammation, and morbidity. University students are at high risk under normal circumstances of stress and anxiety due to extracurricular demands, competing pressures on student time, long study hours, and financial concerns. The COVID 19 pandemic has disrupted normal college students’ lives adding stresses such as lost jobs and family responsibilities such as serving as caregivers, which disproportionally affect minority and rural student. This study aimed to assess the correlation of sleep disorders in New Mexico State University students during COVID 19 with selected variates including base demographics (e.g., gender, age, etc.), lifestyle metrics (e.g., employment status, discipline, class, etc.), living arrangements (e.g., housing type, number of children, etc.), alcohol and tobacco use, vaccination status, family COVID status, and family vaccination status. Single- and multi-factor logistic regressions were performed to analyze the data on the students. Qualtrics software was used to collect data on demographics and sleep disorders. R software was used for data analysis. Correlations were found between sleeping less, sleeping more, and disturbed sleep among several covariate categories. For all three responses, being married (sleeping less: OR = 0.342, 95% CI = 0.181–0.642, sleeping more: OR = 0.265, 95% CI = 0.111–0.591; disturbed sleeping: OR = 0.345, 95% CI = 0.182–0.650), frequency of feeling sleepy-very often (OR = 16.87, 95% CI = 6.571–47.434; OR = 8.393, 95% CI = 3.086–25.298; OR = 13.611, 95% CI = 5.409–36.975) and change in diet- quality decreased (OR = 7.304, 95% CI = 3.615–15.270; OR = 5.250, 95% CI = 2.309–12.558; OR = 4.181, 95% CI = 2.145–8.359) were all significant correlated to change in sleeping behavior. Other correlations were found among covariates and sleep changes. Several covariates were determined to be correlated with the effect of COVID-19 on sleeping.
Measuring small-scale plasma irregularities in the high-latitude E- and F-regions simultaneously
Authors: Ivarsen Magnus F. , St-Maurice Jean-Pierre , Hussey Glenn , Spicher Andres , Jin Yaqi , Lozinsky Adam , Goodwin Lindsay V. , Galeschuk Draven , Park Jaeheung , Clausen Lasse B. N. 
Published: July 2023

AbstractThe ionosphere, Earth’s space environment, exhibits widespread turbulent structuring, or plasma irregularities, visualized by the auroral displays seen in Earth’s polar regions. Such plasma irregularities have been studied for decades, but plasma turbulence remains an elusive phenomenon. We combine scale-dependent measurements from a ground-based radar with satellite observations to characterize small-scale irregularities simultaneously in the bottomside and topside ionosphere and perform a statistical analysis on an aggregate from both instruments over time. We demonstrate the clear mapping of information vertically along the ionospheric altitude column, for field-perpendicular wavelengths down to 1.5 km. Our results paint a picture of the northern hemisphere high-latitude ionosphere as a turbulent system that is in a constant state of growth and decay; energy is being constantly injected and dissipated as the system is continuously attempting an accelerated return to equilibrium. We connect the widespread irregularity dissipation to Pedersen conductance in the E-region, and discuss the similarities between irregularities found in the polar cap and in the auroral region in that context. We find that the effects of a conducting E-region on certain turbulent properties (small-scale spectral index) is near ubiquitous in the dataset, and so we suggest that the electrodynamics of a conducting E-region must be considered when discussing plasma turbulence at high latitudes. This intimate relationship opens up the possibility that E-region conductivity is associated with the generation of F-region irregularities, though further studies are needed to assess that possibility.
In vitro study of nanoliposomes containing curcumin and doxycycline for enhanced antimicrobial photodynamic therapy against Aggregatibacter actinomycetemcomitans
Authors: Afrasiabi Shima , Partoazar Alireza , Chiniforush Nasim 
Published: July 2023

AbstractThe excessive inappropriate use of systemic antibiotics has contributed to the emergence of antibiotic-resistant pathogens, which pose a significant risk to the success of treatment. This study has approached this problem by developing doxycycline-loaded liposome doped with curcumin (NL-Cur+Dox) for combination antibacterial therapy against Aggregatibacter actinomycetemcomitans. The characterization of formulation revealed encapsulation of both drugs in NL-Cur+Dox with an average size of 239 nm and sustained release behavior. Transmission electron microscopy analysis confirmed the vesicular-shaped nanocarriers without any aggregation or crystallization. The cytotoxic and hemolytic activities of NL-Cur+Dox were evaluated. The anti-biofilm and anti-metabolic effects of NL-Cur+Dox -mediated antimicrobial photodynamic therapy (aPDT) were examined. The data indicated that NL-Cur+Dox -mediated aPDT led to a significant reduction of biofilm (82.7%, p = 0.003) and metabolic activity (75%, p < 0.001) of A. actinomycetemcomitans compared to the control. NL-Cur+Dox had no significant cytotoxicity to human gingival fibroblast cells under selected conditions (p = 0.074). In addition, the hemolytic activity of NL-Cur+Dox were negligible (< 5%). These findings demonstrate the potential application of such potent formulations in reducing one of the main bacteria causing periodontitis where the NL-Cur+Dox could be exploited to achieve an improved phototherapeutic efficiency.