bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audio description in video games? Persons with visual disabilities weigh in
Authors: Larreina-Morales María Eugenia , Mangiron Carme 
Published: August 2023

AbstractIn recent years, important advances have taken place to improve game accessibility for all types of players. However, audio description (AD), the access service that translates images into words, is yet to be widely implemented in mainstream games. This paper presents part of the results of the Researching Audio Description Project: Translation, Delivery and New Scenarios (RAD). One of the main objectives of the project is to investigate the potential inclusion of AD in video games in order to improve their accessibility and to contribute to a more enjoyable experience for persons with visual disabilities. First, the evolution of game accessibility is discussed, including the latest developments in the field, both from the industry and research perspectives. Secondly, the RAD Project is presented. Thirdly, the data collected from a survey addressed to blind and low vision persons in Spain is described, for which 106 valid answers were received. Survey topics include the game accessibility barriers encountered by participants, their desired solutions, and their interest in the potential application of AD. Finally, results are discussed regarding similar studies, limitations, and future research. Survey participants are interested in including AD in video games, particularly in non-interactive sections such as cutscenes. Other pressing issues for the game industry regarding accessibility are improving screen reader compatibility, enhancing sounds, and exploring the technical feasibility of game AD in real-time action.
The relationshipbetween anxiety and social outcomes in autistic children and adolescents: A meta-analysis
Authors: Adams Dawn , Ambrose Kathryn , Simpson Kate , Malone Stephanie , Dargue Nicole 
Published: August 2023

AbstractAnxiety is one of the most frequently reported co-occurring conditions for autistic children and adolescents. The relationship between anxiety and social outcomes in autistic youth has been the focus of a range of studies, with mixed results. This meta-analysis aimed to identify the strength of the association between anxiety and a frequently researched social outcome (social competence) in autistic young people and whether that association is influenced by individual or research design factors. A previous preregistered systematic review was updated with a search of the same three databases (CINAHL, ERIC, and PsycINFO) as the original review. Through this, 20 studies with sufficient data on a neurotypically-defined measure of social competence and anxiety were identified. Results were synthesised using a mixed effects model. The meta-analysis on 2,321 participants (from 22 samples) highlighted wide heterogeneity in results. The findings show that anxiety has a significant, small negative impact on social competence (d = − 0.48; 95% CI = − 0.71, − 0.26), meaning that as scores on measures of anxiety increase, scores on measures of social competence decrease. This relationship between anxiety and social competence was moderated by age, becoming weaker as age increased. Whilst this is an important finding for supporting mental health and well-being of autistic young people, the large amount of variance left unexplained suggests that multiple factors, including the use of measures designed for neurotypical people and the potential impact of camouflaging on such measures, need to be considered in future designs.
Individual Target Problems, Self-Observation and Change in Short-Term Psychodynamic Psychotherapy
Authors: Savolainen Juha , Lindfors Olavi , Leiman Mikael 
Published: August 2023

AbstractThe objective of this study was to analyze and illustrate the relationships between different expectations for psychotherapy, quality of self-observation and change in short-term psychodynamic psychotherapy. To conduct this, two patients from the Helsinki Psychotherapy Study were selected for qualitative analysis. The selection was based on the patients’ responses on the Target Complaints (TC) questionnaire, i.e., reasons for seeking psychotherapy, completed as part of the pre-treatment patient assessment. TC responses were classified as psychiatric symptoms or personality and functioning problems. The data for further analysis was selected for both patients from pre-treatment interviews and two follow-up interviews and analyzed in detail by dialogical sequence analysis (DSA), considering the quality of self-observation as a factor contributing to change. As a result, qualitative changes in relation to problematic experiences and development of self-observation appeared in the patient with mainly personality and functioning problems. In contrast, there were little respective changes in the experience of the patient whose target problems were limited to psychiatric symptoms. The results suggest that a patient’s exclusive identification of psychiatric symptoms as target problems may indicate poor suitability for short-term psychodynamic psychotherapy which emphasizes the developmental nature of psychotherapeutic change and the importance of self-observation as a factor of change.
Flammability analysis of poly(ethylene terephthalate) and recycled PET with pyrolyzed filler
Authors: Majka Tomasz M. 
Published: August 2023

AbstractThe future is the recovery of the filler and its reuse in hybrid materials. It is important that as a result of recycling, the filler does not lose its properties, but acquires new ones. The aim of this research work was to investigate the effect of filler recovered by pyrolysis on the flammability of poly(ethylene terephthalate) and recycled PET. It was important to obtain a flammability class higher or equal to the pure PET and RPET matrix. Flammability tests carried out using the UL94, LOI, and PCFC methods allowed perform a first characterization of the properties of materials during their combustion. These studies show that it becomes possible to give specific functional properties to recycled fillers.
Bhushaniella gen. nov. (Cordycipitaceae) on spider eggs sac: a new genus from Thailand and its bioactive secondary metabolites
Authors: Mongkolsamrit Suchada , Sandargo Birthe , Ebada Sherif Saeed , Noisripoom Wasana , Jaiyen Somruetai , Luangsa-ard Janet Jennifer , Stadler Marc 
Published: August 2023

AbstractFungal specimens parasitic on spider egg sacs (Araneidae sensu lato) were collected, isolated, and identified based on molecular phylogenetic analyses of five nuclear loci (ITS, LSU, TEF1, RPB1 and RPB2) combined with morphological data. In this study, one novel monotypic genus is described, Bhushaniella rubra for Thailand. Bhushaniella rubra is characterized by producing superficial perithecia. Its anamorph has a unique character by producing verticillate phialides with a slightly curved neck. A concurrent evaluation of the secondary metabolites of the mycelial extracts of the new fungus revealed the presence of picoline alkaloids of the penicolinate type, for which we propose the trivial names penicolinates F and G. Their chemical structures were elucidated by two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy and high resolution mass spectrometry (HR-MS). They only showed weak to no antibiotic activity and were devoid of significant cytotoxic effects.
Leading-by-example: a meta-analysis
Authors: Eisenkopf Gerald , Kölpin Torben 
Published: August 2023

AbstractWe provide a parsimonious model of leadership in social dilemma situations and test it with a meta-analysis of experimental studies. We focus on studies with treatments that allow for sequential contributions to a public good [as in Güth et al. (J Public Econ 91:1023–1042, 2007)]. The group members observe the contribution of a leader before contributing themselves. We compare the results with simultaneous contribution treatments from the same studies. Our results confirm that the establishment of a leader indeed leads to persistently higher and more coordinated contributions. As predicted, the aggregate effect remains stable over time and increases in group size even though leaders and followers have more divergent contribution patterns in larger groups. We also find empirical support for an explanation of the observed ‘leader’s curse’.
Problematizing Modern Democracy in the United States:
Authors: Simon Julia 
Published: August 2023

AbstractSince Donald Trump’s presidency and the diverse efforts to undermine the transfer of power after the 2020 election, the risks of extreme polarization and democratic backsliding in the United States (US) have been highlighted in the literature. Yet the epistemic dimension of these developments remains underresearched. Embedded in a genealogical Foucauldian governmentality/counter-conduct approach, this contribution addresses the puzzle of how election denialism and related (violent) anti-system activity are being rationalized, legitimized, and anchored in political subjectivities as efforts to ‘protect’ American democracy. This perspective allows to inquire into liberalism’s authoritarian potential that can be mobilized through different forms of counter-conduct. The study analytically disentangles these forms based on their prime targets, modes of operation, and the forms of knowledge they rely on. Focusing on the swing state of Arizona, the empirical analysis furthermore highlights the role of the subnational level in interlinking counter-conduct and (autocratizing) governmental practices in a federal system. Conceptually, the study renders visible a profound struggle over the epistemic foundations of the current liberal constitutional and political order that clearly transcends the issue of the 2020 election, Donald Trump, and even the context of the United States. Indeed, similar patterns of subjectivation and counter-conduct can also be detected for example in Germany. Moreover, this paper expands the scope of the concept of counter-conduct to study radical right-wing contestations and related questions of epistemic (in)justice. It thereby seeks to encourage debate on how political science can address the pluralization and polarization of contents, standards, and forms of knowledge as they become relevant to democratic backsliding.
Tree diversity and social–ecological resilience of agroforestry after volcanic ash deposition in Indonesia
Authors: Sari Rika Ratna , Priyadarshini Rossyda , Rozendaal Danaë M. A. , Saputra Danny Dwi , Hairiah Kurniatun , van Noordwijk Meine 
Published: August 2023

AbstractSmallholder farmers and their agroecosystems in active volcanic landscapes need to deal with and recover from eruptions. Resilience to extreme shocks may increase with system diversity, enhancing food and income security and ecosystem services provision; however, the longer term effects of volcanic ash are rarely assessed. To test the hypothesis that tree diversity contributes to the social–ecological resilience of coffee-based agroforestry, we quantified (1) the immediate effects of deposition of a 15-cm ash layer on tree survival, (2) the effect of volcanic ash on aboveground C stocks, tree diversity and wood density frequencies, (3) litter layer dynamics, and (4) farming system and income recovery 3 years after. Observations in four land-use systems before and after ash deposition (remnant forest, coffee-based complex and simple agroforestry, annual crops) were complemented by 46 farmer interviews on tree species’ survival, system, and financial recovery. Based on farmer interviews, low-wood-density trees were most affected by volcanic ash deposition. Ash deposition did not, after 3 years and across land-use systems, significantly change tree density, basal area, or C stocks. In contrast, species richness in coffee-based agroforestry increased significantly. Standing litter stocks in agroforestry decreased, but slower decomposition partially compensated for reduced litter input. Farmers stated that diversity and flexibility in coffee-based agroforestry support a system recovery that is faster than that for annual crops, suppressing income fluctuation. Farmer’s adaptive responses to enhance species diversity contributed to the resilience of farms, by retaining basic system structure and functions of agroforestry, and increasing product diversity and income.
Graphical abstract
Shape-based functional data analysis
Authors: Wu Yuexuan , Huang Chao , Srivastava Anuj 
Published: August 2023

AbstractFunctional data analysis (FDA) is a fast-growing area of research and development in statistics. While most FDA literature imposes the classical$$\mathbb {L}^2$$L2Hilbert structure on function spaces, there is an emergent need for a different, shape-based approach for analyzing functional data. This paper reviews and develops fundamental geometrical concepts that help connect traditionally diverse fields of shape and functional analyses. It showcases that focusing on shapes is often more appropriate when structural features (number of peaks and valleys and their heights) carry salient information in data. It recaps recent mathematical representations and associated procedures for comparing, summarizing, and testing the shapes of functions. Specifically, it discusses three tasks: shape fitting, shape fPCA, and shape regression models. The latter refers to the models that separate the shapes of functions from their phases and use them individually in regression analysis. The ensuing results provide better interpretations and tend to preserve geometric structures. The paper also discusses an extension where the functions are not real-valued but manifold-valued. The article presents several examples of this shape-centric functional data analysis using simulated and real data.
Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis
Authors: Amerikanou Charalampia , Valsamidou Evdokia , Karavoltsos Sotirios , Tagkouli Dimitra , Sakellari Aikaterini , Kontou Maria , Houhoula Dimitra , Kalogeropoulos Nick , Zoumpoulakis Panagiotis , Kaliora Andriana C. 
Published: August 2023

AbstractOsteoarthritis (OA) is the most common form of arthritis, that causes a significant decrease in the quality of life of the afflicted and constitutes a great burden for the socioeconomic system. Trace elements and heavy metals are implicated in the pathophysiology of OA, exacerbating inflammatory and oxidative stress responses. The aim of this cross-sectional study was to quantify metals in plasma samples of Greek OA patients and explore their link with disease related parameters, health status or quality of life, as well as epigenetic OA markers. This is the first study on plasma metal levels in Greek knee OA patients. To achieve precision in plasma metal and miRNA measurements, high-quality samples were selected from a subset of 34 participants (NCT04783792). Demographic, quality of life, clinical, biochemical, inflammation, oxidative stress, and anthropometric parameters, as well as microRNA levels were assessed. Significant correlations were found between circulating metals with OA related parameters or with measured microRNAs. Also, significant positive associations between plasma copper (Cu) levels and CRP (p = 0.033) or IL-6 (p = 0.001) occurred when adjusting for age, gender, BMI, physical activity level, smoking, disease severity, total arthroplasty, and dietary intake of the respective metal. Cu’s role in OA is bidirectional, and this study confirms the findings that in OA, Cu is positively associated with inflammation. Such relationships between lifestyle, environment and OA enhance our understanding and encourage further study on metals related to OA inflammation.
Spreading of Tau Protein Does Not Depend on Aggregation Propensity
Authors: Rodrigues Sara , Anglada-Huguet Marta , Hochgräfe Katja , Kaniyappan Senthilvelrajan , Wegmann Susanne , Mandelkow Eva-Maria 
Published: August 2023

AbstractThe stereotypical progression of Tau pathology during Alzheimer disease has been attributed to trans-neuronal spreading of misfolded Tau proteins, followed by prion-like templated aggregation of Tau. The nature of Tau and the cellular mechanisms of Tau spreading are still under debate. We hypothesized that Tau’s propensity for aggregation would correlate with its ability to spread across synapses and propagate pathology. To study the progressive propagation of Tau proteins in brain regions relevant for Alzheimer disease, we used mice expressing near-physiological levels of full-length human Tau protein carrying pro-aggregant (TauΔK280, TauΔK) or anti-aggregant (TauΔK280-PP, TauΔK−PP) mutations in the entorhinal cortex (EC). To enhance Tau expression in the EC, we performed EC injections of adeno-associated virus (AAV) particles encoding TauΔK or TauΔK−PP. The brains of injected and non-injected EC/TauΔK and EC/TauΔK−PP mice were studied by immunohistological and biochemical techniques to detect Tau propagation to dentate gyrus (DG) neurons and Tau-induced pathological changes. Pro- and anti-aggregant mice had comparable low transgene expression (~0.2 times endogenous mouse Tau). They accumulated human Tau at similar rates and only in expressing EC neurons, including their axonal projections of the perforant path and presynaptic terminals in the molecular layer of the DG. Pro-aggregant EC/TauΔK mice showed misfolded Tau and synaptic protein alterations in EC neurons, not observed in anti-aggregant EC/TauΔK−PP mice. Additional AAV-mediated expression of TauΔK or TauΔK−PP in EC/TauΔK or EC/TauΔK−PP mice, respectively, increased the human Tau expression to ~0.65 times endogenous mouse Tau, with comparable spreading of TauΔK and TauΔK−PP throughout the EC. There was a low level of transcellular propagation of Tau protein, without pathological phosphorylation or misfolding, as judged by diagnostic antibodies. Additionally, TauΔK but not TauΔK−PP expression induced hippocampal astrogliosis. Low levels of pro- or anti-aggregant full-length Tau show equivalent distributions in EC neurons, independent of their aggregation propensity. Increasing the expression via AAV induce local Tau misfolding in the EC neurons, synaptotoxicity, and astrogliosis and lead to a low level of detectable trans-neuronal spreading of Tau. This depends on its concentration in the EC, but, contrary to expectations, does not depend on Tau’s aggregation propensity/misfolding and does not lead to templated misfolding in recipient neurons.
Role of Brain Liver X Receptor in Parkinson’s Disease: Hidden Treasure and Emerging Opportunities
Authors: Alnaaim Saud A. , Al-Kuraishy Hayder M. , Alexiou Athanasios , Papadakis Marios , Saad Hebatallah M. , Batiha Gaber El-Saber 
Published: August 2023

AbstractParkinson’s disease (PD) is a neurodegenerative disease due to the degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). The liver X receptor (LXR) is involved in different neurodegenerative diseases. Therefore, the objective of the present review was to clarify the possible role of LXR in PD neuropathology. LXRs are the most common nuclear receptors of transcription factors that regulate cholesterol metabolism and have pleiotropic effects, including anti-inflammatory effects and reducing intracellular cholesterol accumulation. LXRs are highly expressed in the adult brain and act as endogenous sensors for intracellular cholesterol. LXRs have neuroprotective effects against the development of neuroinflammation in different neurodegenerative diseases by inhibiting the expression of pro-inflammatory cytokines. LXRs play an essential role in mitigating PD neuropathology by reducing the expression of inflammatory signaling pathways, neuroinflammation, oxidative stress, mitochondrial dysfunction, and enhancement of BDNF signaling.In conclusion, LXRs, through regulating brain cholesterol homeostasis, may be effectual in PD. Also, inhibition of node-like receptor pyrin 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-κB) by LXRs could effectively prevent neuroinflammation in PD. Taken together, LXRs play a crucial role in PD neuropathology by inhibiting neuroinflammation and associated degeneration of DNs.
A stochastic policy algorithm for seasonal hydropower planning
Authors: Grini Håkon S. , Danielsen Anders S. , Fleten Stein-Erik , Kleiven Andreas 
Published: August 2023

AbstractHydropower producers need to plan several months or years ahead to estimate the opportunity value of water stored in their reservoirs. The resulting large-scale optimization problem is computationally intensive, and model simplifications are often needed to allow for efficient solving. Alternatively, one can look for near-optimal policies using heuristics that can tackle non-convexities in the production function and a wide range of modelling approaches for the price- and inflow dynamics. We undertake an extensive numerical comparison between the state-of-the-art algorithm stochastic dual dynamic programming (SDDP) and rolling forecast-based algorithms, including a novel algorithm that we develop in this paper. We name it Scenario-based Two-stage ReOptimization abbreviated as STRO. The numerical experiments are based on convex stochastic dynamic programs with discretized exogenous state space, which makes the SDDP algorithm applicable for comparisons. We demonstrate that our algorithm can handle inflow risk better than traditional forecast-based algorithms, by reducing the optimality gap from 2.5 to 1.3% compared to the SDDP bound.
Analysis of CDR1 and MDR1 Gene Expression and ERG11 Substitutions in Clinical Candida tropicalis Isolates from Alexandria, Egypt
Authors: El-Kholy Mohammed A. , Helaly Ghada F. , El Ghazzawi Ebtisam F. , El-Sawaf Gamal , Shawky Sherine M. 
Published: August 2023

Abstract
Introduction
Candida tropicalis is a common non-albicans Candida (NAC) species that causes numerous fungal infections. Increasing antifungal resistance to azoles in NAC is becoming a major health problem worldwide; however, in Egypt, almost no data is available regarding fluconazole resistance mechanisms in C. tropicalis. The current study aims to investigate two possible important molecular mechanisms involved in fluconazole resistance in C. tropicalis isolates.

Materials
Fifty-four clinical C. tropicalis isolates were included. Identification and antifungal susceptibility profiles of the isolates were carried out using the VITEK 2 compact system. The molecular investigation of fluconazole resistance included the expression of the CDR1 and MDR1 genes by quantitative real-time RT-PCR as well as the sequence analysis of the ERG11 gene.

Results
Antifungal susceptibility testing identified 30 fluconazole-non-susceptible isolates. Statistically, CDR1 gene expression in fluconazole-non-susceptible isolates was significantly higher than that in fluconazole-susceptible isolates, with MDR1 gene expression levels that were similar in both non-susceptible and susceptible isolates. Sequence analysis of the ERG11 gene of 26 fluconazole-resistant isolates identified two missense mutations: A395T (Y132F) and G1390A (G464S).

Conclusions
This study has highlighted the role of overexpression of the CDR1 gene and ERG11 gene mutations in fluconazole non-susceptibility. Further studies in Egypt are required to investigate other possible molecular mechanisms involved in azole resistance.