bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-Year Adverse Outcomes Among US Adults With Post–COVID-19 Condition vs Those Without COVID-19 in a Large Commercial Insurance Database
Authors: DeVries Andrea , Shambhu Sonali , Sloop Sue , Overhage J. Marc 
Published: March 2023

ImportanceMany individuals experience ongoing symptoms following the onset of COVID-19, characterized as postacute sequelae of SARS-CoV-2 or post–COVID-19 condition (PCC). Less is known about the long-term outcomes for these individuals.ObjectiveTo quantify 1-year outcomes among individuals meeting a PCC definition compared with a control group of individuals without COVID-19.Design, Setting, and ParticipantsThis cohort study with a propensity score–matched control group included members of commercial health plans and used national insurance claims data enhanced with laboratory results and mortality data from the Social Security Administration’s Death Master File and Datavant Flatiron data. The study sample consisted of adults meeting a claims-based definition for PCC with a 2:1 matched control cohort of individuals with no evidence of COVID-19 during the time period of April 1, 2020, to July 31, 2021.ExposuresIndividuals experiencing postacute sequelae of SARS-CoV-2 using a Centers for Disease Control and Prevention–based definition.Main Outcomes and MeasuresAdverse outcomes, including cardiovascular and respiratory outcomes and mortality, for individuals with PCC and controls assessed over a 12-month period.ResultsThe study population included 13 435 individuals with PCC and 26 870 individuals with no evidence of COVID-19 (mean [SD] age, 51 [15.1] years; 58.4% female). During follow-up, the PCC cohort experienced increased health care utilization for a wide range of adverse outcomes: cardiac arrhythmias (relative risk [RR], 2.35; 95% CI, 2.26-2.45), pulmonary embolism (RR, 3.64; 95% CI, 3.23-3.92), ischemic stroke (RR, 2.17; 95% CI, 1.98-2.52), coronary artery disease (RR, 1.78; 95% CI, 1.70-1.88), heart failure (RR, 1.97; 95% CI, 1.84-2.10), chronic obstructive pulmonary disease (RR, 1.94; 95% CI, 1.88-2.00), and asthma (RR, 1.95; 95% CI, 1.86-2.03). The PCC cohort also experienced increased mortality, as 2.8% of individuals with PCC vs 1.2% of controls died, implying an excess death rate of 16.4 per 1000 individuals.Conclusions and RelevanceThis cohort study leveraged a large commercial insurance database and found increased rates of adverse outcomes over a 1-year period for a PCC cohort surviving the acute phase of illness. The results indicate a need for continued monitoring for at-risk individuals, particularly in the area of cardiovascular and pulmonary management.
TrDosePred: A deep learning dose prediction algorithm based on transformers for head and neck cancer radiotherapy
Authors: Hu Chenchen , Wang Haiyun , Zhang Wenyi , Xie Yaoqin , Jiao Ling , Cui Songye 
Published: March 2023

AbstractBackgroundIntensity‐Modulated Radiation Therapy (IMRT) has been the standard of care for many types of tumors. However, treatment planning for IMRT is a time‐consuming and labor‐intensive process.PurposeTo alleviate this tedious planning process, a novel deep learning based dose prediction algorithm (TrDosePred) was developed for head and neck cancers.MethodsThe proposed TrDosePred, which generated the dose distribution from a contoured CT image, was a U‐shape network constructed with a convolutional patch embedding and several local self‐attention based transformers. Data augmentation and ensemble approach were used for further improvement. It was trained based on the dataset from Open Knowledge‐Based Planning Challenge (OpenKBP). The performance of TrDosePred was evaluated with two mean absolute error (MAE) based scores utilized by OpenKBP challenge (i.e., Dose score and DVH score) and compared to the top three approaches of the challenge. In addition, several state‐of‐the‐art methods were implemented and compared to TrDosePred.ResultsThe TrDosePred ensemble achieved the dose score of 2.426 Gy and the DVH score of 1.592 Gy on the test dataset, ranking at 3rd and 9th respectively in the leaderboard on CodaLab as of writing. In terms of DVH metrics, on average, the relative MAE against the clinical plans was 2.25% for targets and 2.17% for organs at risk.ConclusionsA transformer‐based framework TrDosePred was developed for dose prediction. The results showed a comparable or superior performance as compared to the previous state‐of‐the‐art approaches, demonstrating the potential of transformer to boost the treatment planning procedures.
Multisystem proteinopathies (MSPs) and MSP‐like disorders: Clinical‐pathological‐molecular spectrum
Authors: Chompoopong Pitcha , Oskarsson Björn , Madigan Nicolas N. , Mirman Igal , Martinez‐Thompson Jennifer M. , Liewluck Teerin , Milone Margherita 
Published: March 2023

AbstractObjectivesMutations in VCP, HNRNPA2B1, HNRNPA1, and SQSTM1, encoding RNA‐binding proteins or proteins in quality‐control pathways, cause multisystem proteinopathies (MSP). They share pathological findings of protein aggregation and clinical combinations of inclusion body myopathy (IBM), neurodegeneration [motor neuron disorder (MND)/frontotemporal dementia (FTD)], and Paget disease of bone (PDB). Subsequently, additional genes were linked to similar but not full clinical‐pathological spectrum (MSP‐like disorders). We aimed to define the phenotypic‐genotypic spectrum of MSP and MSP‐like disorders at our institution, including long‐term follow‐up features.MethodsWe searched the Mayo Clinic database (January 2010–June 2022) to identify patients with mutations in MSP and MSP‐like disorders causative genes. Medical records were reviewed.ResultsThirty‐one individuals (27 families) had pathogenic mutations in: VCP (n = 17), SQSTM1 + TIA1 (n = 5), TIA1 (n = 5), MATR3, HNRNPA1, HSPB8, and TFG (n = 1, each). Myopathy occurred in all but 2 VCP‐MSP patients with disease onset at age 52 (median). Weakness pattern was limb‐girdle in 12/15 VCP‐MSP and HSPB8 patient, and distal‐predominant in other MSP and MSP‐like disorders. Twenty/24 muscle biopsies showed rimmed vacuolar myopathy. MND and FTD occurred in 5 (4 VCP, 1 TFG) and 4 (3 VCP, 1 SQSTM1 + TIA1) patients, respectively. PDB manifested in 4 VCP‐MSP. Diastolic dysfunction occurred in 2 VCP‐MSP. After 11.5 years (median) from symptom onset, 15 patients ambulated without gait‐aids; loss of ambulation (n = 5) and death (n = 3) were recorded only in VCP‐MSP.InterpretationVCP‐MSP was the most common disorder; rimmed vacuolar myopathy was the most frequent manifestation; distal‐predominant weakness occurred frequently in non‐VCP‐MSP; and cardiac involvement was observed only in VCP‐MSP.
Immunity‐on‐a‐Chip: Integration of Immune Components into the Scheme of Organ‐on‐a‐Chip Systems
Authors: Ramadan Qasem , Hazaymeh Rana , Zourob Mohammed 
Published: March 2023

AbstractStudying the immune system in vitro aims to understand how, when, and where the immune cells migrate/differentiate and respond to the various triggering events and the decision points along the immune response journey. It becomes evident that organ‐on‐a‐chip (OOC) technology has a superior capability to recapitulate the cell‐cell and tissue‐tissue interaction in the body, with a great potential to provide tools for tracking the paracrine signaling with high spatial‐temporal precision and implementing in situ real‐time, non‐destructive detection assays, therefore, enabling extraction of mechanistic information rather than phenotypic information. However, despite the rapid development in this technology, integration of the immune system into OOC devices stays among the least navigated tasks, with immune cells still the major missing components in the developed models. This is mainly due to the complexity of the immune system and the reductionist methodology of the OOC modules. Dedicated research in this field is demanded to establish the understanding of mechanism‐based disease endotypes rather than phenotypes. Herein, we systemically present a synthesis of the state‐of‐the‐art of immune‐cantered OOC technology. We comprehensively outlined what is achieved and identified the technology gaps emphasizing the missing components required to establish immune‐competent OOCs and bridge these gaps.
Interfacial Chemical Bond and Oxygen Vacancy‐Enhanced In2O3/CdSe‐DETA S‐scheme Heterojunction for Photocatalytic CO2 Conversion
Authors: Zhao Zhiwei , Wang Zhongliao , Zhang Jinfeng , Shao Chunfeng , Dai Kai , Fan Ke , Liang Changhao 
Published: March 2023

AbstractThe S‐scheme heterojunctions have great potential for photocatalytic carbon dioxide reduction due to their unique carrier migration pathways, superior carrier separation efficiencies, and high redox capacities. However, the precise process of the oriented powerful electron transport remains a great challenge. Herein, an InOCd bond‐modulated S‐scheme heterojunction of In2O3/CdSe‐DETA is synthesized by a simple microwave‐assisted hydrothermal method for the accelerated photogenerated electron transfer. Meanwhile, the oxygen vacancies (Vo) of In2O3 have an electron capture effect. Consequently, thanks to the synergistic effect of this In‐Vo‐In‐O‐Cd structural units at the interface, electrons are extracted and rapidly transferred to the surface‐active sites, which improves the electronic coupling of CO2. This finding precisely adjusts the electron transfer pathway and shortens the electron transfer distance. The synergistic effect of this chemical bond established in the S‐scheme heterostructure with oxygen vacancies in In2O3 (Vo‐In2O3) provides new insights into photocatalytic CO2 reduction.
Multifunctional Small Molecule as Buried Interface Passivator for Efficient Planar Perovskite Solar Cells
Authors: Wu Meizi , Duan Yuwei , Yang Lu , You Peng , Li Zhijun , Wang Jungang , Zhou Hui , Yang Shaomin , Xu Dongfang , Zou Hong , Liu Zhike 
Published: March 2023

AbstractThe improvement of power conversion efficiency (PCE) and stability of the perovskite solar cell (PSC) is hindered by carrier recombination originating from the defects at the buried interface of the PSC. It is crucial to suppress the nonradiative recombination and facilitate carrier transfer in PSC via interface engineering. Herein, P‐biguanylbenzoic acid hydrochloride (PBGH) is developed to modify the tin oxide (SnO2)/perovskite interface. The effects of PBGH on carrier transportation, perovskite growth, defect passivation, and PSC performance are systematically investigated. On the one hand, the PBGH can effectively passivate the trap states of Sn dangling bonds and O vacancies on the SnO2 surface via Lewis acid/base coordination, which is conducive to improving the conductivity of SnO2 film and accelerating the electron extraction. On the other hand, PBGH modification assists the formation of high‐quality perovskite film with low defect density due to its strong interaction with PbI2. Consequently, the PBGH‐modified PSC exhibits a champion power conversion efficiency (PCE) of 24.79%, which is one of the highest PCEs among all the FACsPbI3‐based PSCs reported to date. In addition, the stabilities of perovskite films and devices under high temperature/humidity and light illumination conditions are also systematically studied.
Biodegradable Poly(ester) Urethane Acrylate Resins for Digital Light Processing: From Polymer Synthesis to 3D Printed Tissue Engineering Constructs
Authors: Wang Rong , Damanik Febriyani , Kuhnt Tobias , Jaminon Armand , Hafeez Shahzad , Liu Hong , Ippel Hans , Dijkstra Pieter J. , Bouvy Nicole , Schurgers Leon , ten Cate A. Tessa , Dias Aylvin , Moroni Lorenzo , Baker Matthew B. 
Published: March 2023

AbstractDigital light processing (DLP) is an accurate and fast additive manufacturing technique to produce a variety of products, from patient‐customized biomedical implants to consumer goods. However, DLP's use in tissue engineering has been hampered due to a lack of biodegradable resin development. Herein, a library of biodegradable poly(esters) capped with urethane acrylate (with variations in molecular weight) is investigated as the basis for DLP printable resins for tissue engineering. The synthesized oligomers show good printability and are capable of creating complex structures with mechanical moduli close to those of medium‐soft tissues (1–3 MPa). While fabricated films from different molecular weight resins show few differences in surface topology, wettability, and protein adsorption, the adhesion and metabolic activity of NCTC clone 929 (L929) cells and human dermal fibroblasts (HDFs) are significantly different. Resins from higher molecular weight oligomers provide greater cell adhesion and metabolic activity. Furthermore, these materials show compatibility in a subcutaneous in vivo pig model. These customizable, biodegradable, and biocompatible resins show the importance of molecular tuning and open up new possibilities for the creation of biocompatible constructs for tissue engineering.
Photo‐Responsive Hydrogel for Contactless Dressing Change to Attenuate Secondary Damage and Promote Diabetic Wound Healing
Authors: Li Zi‐Yuan , Zhang Xiao‐Jie , Gao Yi‐Ming , Song Yanyan , Sands Mia X. , Zhou Shuang‐Bai , Li Qing‐Feng , Zhang Junji 
Published: March 2023

AbstractDressing change is a significant and inevitable process during wound healing. Possible secondary damage caused through dressing removal may impose a great threat on wound recovery, thus resulting in healing delays and ultimately a higher cost of hospitalization. Hence, a non‐contact refreshable dressing with an ease of operation is of great desire, especially for chronic wounds where a long‐term and repeated dressing change would be performed. Herein, an all‐light‐operated hydrogel dressing that would achieve a fast and remote‐controllable dressing change (30 s for gelation/4 min for dissolution upon light irradiation) for chronic wounds is presented. In a diabetic murine model, substantially improved wound healing within 2–3 weeks is observed due to attenuated secondary damage during repeated dressing changes. Moreover, a promising facilitation of the healing processes of epithelialization, collagen deposition, cell proliferation, and inflammatory regulation is also detected, representing a synergistic effect of the photo‐responsive hydrogel dressing for therapeutic efficiency.
Sustained Release of Dicumarol via Novel Grafted Polymer in Electrospun Nanofiber Membrane for Treatment of Peritendinous Adhesion
Authors: Li Yanhao , Hu Chengfang , Hu Bo , Tian Jian , Zhao Gang , Cai Chuandong , Li Yuange , Sun Zhenyu , Wang Shuo , Pang Sa , Bao Rong , Tao Zaijing , Chen Huajiang , Wu Jinglei , Liu Shen 
Published: March 2023

AbstractThe prevention and treatment of post‐traumatic peritendinous adhesion (PA) have always been a great difficulty for orthopedic surgeons. Current treatments include resecting surgery, non‐steroidal anti‐inflammatory drugs (NSAIDs) usage and implantable membranes, often target single disease pathogenic processes, resulting in unfavorable therapeutic outcomes. Here a polylactic acid (PLA)‐dicumarol conjugates‐electrospun nanofiber membrane (ENM) (PCD) is generated, which can achieve spatial accuracy and temporal sustainability in drug release. It is further demonstrated that PCD possesses a significantly higher and more sustainable drug release profile than traditional drug‐loading ENM. By providing a physical barrier and continuous releasing of dicumarol, PCD implantation significantly reduces tissue adhesion by 25%, decreases fibroblasts activity and inhibits key fibrogenic cytokine transforming growth factor beta (TGFβ) production by 30%, and improves the biomechanical tendon property by 14.69%. Mechanistically, PCD potently inhibits the connexin43 (Cx43) and thereby tunes down the fibroblastic TGFβ/Smad3 signaling pathway. Thus, this approach leverages the anti‐adhesion effect of dicumarol and drug release properties of grafted copolymer ENM by esters to provide a promising therapeutic strategy for patients who suffer from PA.
Interface Engineering for Highly Efficient Organic Solar Cells
Authors: Tang Haoran , Bai Yuanqing , Zhao Haiyang , Qin Xudong , Hu Zhicheng , Zhou Cheng , Huang Fei , Cao Yong 
Published: March 2023

AbstractOrganic solar cells (OSCs) have made dramatic advancements during the past decades owing to the innovative material design and device structure optimization, with power conversion efficiencies surpassing 19% and 20% for single‐junction and tandem devices, respectively. Interface engineering, by modifying interface properties between different layers for OSCs, has become a vital part to promote the device efficiency. It is essential to elucidate the intrinsic working mechanism of interface layers, as well as the related physical and chemical processes that manipulate device performance and long‐term stability. In this article, the advances in interface engineering aimed to pursue high‐performance OSCs are reviewed. The specific functions and corresponding design principles of interface layers are summarized first. Then, the anode interface layer, cathode interface layer in single‐junction OSCs, and interconnecting layer of tandem devices are discussed in separate categories, and the interface engineering‐related improvements on device efficiency and stability are analyzed. Finally, the challenges and prospects associated with application of interface engineering are discussed with the emphasis on large‐area, high‐performance, and low‐cost device manufacturing.
A Scalable Platform for Fabricating Biodegradable Microparticles with Pulsatile Drug Release
Authors: Graf Tyler P. , Qiu Sherry Yue , Varshney Dhruv , Laracuente Mei‐Li , Euliano Erin M. , Munnangi Pujita , Pogostin Brett H. , Baryakova Tsvetelina , Garyali Arnav , McHugh Kevin J. 
Published: March 2023

AbstractPulsatile drug delivery systems have the potential to improve patient adherence and therapeutic efficacy by providing a sequence of doses in a single injection. Herein, a novel platform, termed Particles Uniformly Liquified and Sealed to Encapsulate Drugs (PULSED) is developed, which enables the high‐throughput fabrication of microparticles exhibiting pulsatile release. In PULSED, biodegradable polymeric microstructures with an open cavity are formed using high‐resolution 3D printing and soft lithography, filled with drug, and sealed using a contactless heating step in which the polymer flows over the orifice to form a complete shell around a drug‐loaded core. Poly(lactic‐co‐glycolic acid) particles with this structure can rapidly release encapsulated material after delays of 10 ± 1, 15 ± 1, 17 ± 2, or 36 ± 1 days in vivo, depending on polymer molecular weight and end group. The system is even compatible with biologics, releasing over 90% of bevacizumab in its bioactive form after a two‐week delay in vitro. The PULSED system is highly versatile, offering compatibility with crystalline and amorphous polymers, easily injectable particle sizes, and compatibility with several newly developed drug loading methods. Together, these results suggest that PULSED is a promising platform for creating long‐acting drug formulations that improve patient outcomes due to its simplicity, low cost, and scalability.
Surface‐Dependent Electrocatalytic Activity of CoSe2 for Lithium Sulfur Battery
Authors: Liu Xiaobiao , Zheng Yibing , Zhang Mengjiao , Qi Shiyang , Tan Ming , Zhao Ruwei , Zhao Mingwen 
Published: March 2023

AbstractElectrocatalysts play key roles in improving the performance of lithium sulfur (Li‐S) batteries. Here, the electrocatalytic activity of different CoSe2 surfaces for the polysulfide redox reactions in Li‐S batteries, by means of first‐principle calculations is considered. The authors demonstrate that there are obvious differences in surface energy (0.7–2.34 J m−2), adsorption energy for lithium polysulfides (LiPSs) (1.2–3.5 eV), Gibbs free energy of sulfur reduction reaction (SRR) (0.37–1.16 eV), and Li2S decomposition barrier (0.15–0.94 eV) among different CoSe2 surfaces, and thus lead to the different electrocatalytic activity for different CoSe2 surface. The stoichiometric CoSe2 surface with high surface energy, such as the (001) surface, tends to have stronger adsorption energy and larger SRR Gibbs free energy for LiPSs. The surface electron states are mainly dominated by p–d hybridization orbitals and the p‐band center is vital for the surface electrocatalytic properties. Such surface‐dependent mechanism may shed light on the design of sulfur host materials for high‐performance Li‐S batteries.
In Vivo Activity of Hydrogen‐Peroxide Generating Electrochemical Bandage Against Murine Wound Infections
Authors: Raval Yash S. , Fleming Derek , Mohamed Abdelrhman , Karau Melissa J. , Mandrekar Jayawant N. , Schuetz Audrey N. , Greenwood‐Quaintance Kerryl E. , Beyenal Haluk , Patel Robin 
Published: March 2023

AbstractBiofilms formed by antibiotic‐resistant bacteria in wound beds challenge the treatment of wound infections. In this work, the activity of a novel electrochemical bandage (e‐bandage) composed of carbon fabric and controlled by a wearable potentiostat, designed to continuously deliver low amounts of hydrogen peroxide (H2O2), is evaluated against methicillin‐resistant Staphylococcus aureus (MRSA), multidrug‐resistant Pseudomonas aeruginosa (MDR‐PA) and mixed‐species (MRSA and MDR‐PA) wound infections. Wounds created on Swiss Webster mice are infected with the above‐named bacteria and biofilms allow to establish in wound beds for 3 days. e‐Bandages, which electrochemically reduce dissolved oxygen to H2O2 when polarized at −0.6 VAg/AgCl, are placed atop infected wound beds and polarized continuously for 48 h. Polarized e‐bandage treatment results in significant reductions (p <0.001) of both monospecies and mixed‐species wound infections. After e‐bandage treatment, electron microscopy shows degradation of bacterial cells, and histopathology shows no obvious alterations to the inflammatory host response. Blood biochemistries show no abnormalities. Taken all together, results of this work suggest that the described H2O2‐producing e‐bandage can reduce in vivo MRSA, MDR‐PA, and mixed‐species wound biofilms, and should be further developed as a potential antibiotic‐free strategy for treatment of wound infections.
A Theory‐Driven Complementary Interface Effect for Fast‐Kinetics and Ultrastable Zn Metal Anodes in Aqueous/Solid Electrolytes
Authors: Li Fan , Ma Dingtao , Ouyang Kefeng , Yang Ming , Qiu Jimin , Feng Juan , Wang Yanyi , Mi Hongwei , Sun Shichang , Sun Lingna , He Chuanxin , Zhang Peixin 
Published: March 2023

AbstractThe undesirable side reactions and uncontrolled deposition leads to the electrochemical failure of Zn metal anodes. Herein, driven by theory calculations, a surface texture engineering and passivation layer protection dual‐interface strategy is developed. Benefiting from the complementary interface effect, such a dual‐interface can realize the integrated regulation of interfacial transport and deposition. That is, inhibiting water‐induced side reactions, accelerating the de‐solvation of hydrated zinc ions, homogenizing the ion flux, and guiding the Zn(002)‐preferred orientation deposition. As a result, such a dual‐interface modulated Zn electrode enables a significantly extended stability and a smaller nucleation barrier and polarization effect. Unexpectedly, it can steadily operate for 6600 h at 0.5 mA cm−2 and 0.5 mA h cm−2, corresponding to a lifespan >9 months. Highly reversible Zn plating and stripping can be still retained when the current density is improved up to 1, 5, 10, and even 20 mA cm−2. Beyond that, when it is applied to Zn metal batteries, enhanced rate capability, and cyclic stability can be realized in both aqueous Zn/MnO2 batteries and solid‐state Zn/VO2 batteries. This design concept of complementary interface effect is expected to provide a new insight into high reversibility Zn metal anodes.