bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply Chain Model for Management of Materials for Construction Projects
Authors: El-Madany Mohamed Eslam , Kotb Mostafa Hassan , Rahim Abdul Rady Abdul , Nagy Alsayed Mohamed 
Published: January 2023

Abstract
The construction industry is the primary economic sector, playing an essential role in the country's economic growth. Construction is famous for exceeding the specified cost and duration of the project compared to other industries due to its high fragmentation. Material costs represent most of the direct costs of a construction project. As an innovative management model, supply chain management provides a new solution for resolving material handling in construction projects. However, the construction supply chain faces many challenges due to changing orders. This study developed a model to track changes in project stages to establish a flexible supply chain. The developed model (KOTB) is divided into three stages (the planning stage, the suppliers stage, and the inventory stage).These stages have input and output data representing the main factors of the construction supply chain. KOTB represents the project cycle of the construction supply chain, in which the user can have a master plan for any project element. The output data are: planning for project and material, supplier selection, inventory levels during the project, and material order (time and quantities). KOTB has been validated through the insertion of three different construction projects (constructing a governmental building, a residential building, and a playground). The result was compared using a manual calculation.
Identification and Validation of Necroptosis-Related Gene Signatures to Predict Clinical Outcomes and Therapeutic Responses in Acute Myeloid Leukemia
Authors: Wen Xiang-mei , Xu Zi-jun , Ma Ji-chun , Xia Pei-hui , Jin Ye , Chen Xin-yi , Qian Wei , Lin Jiang , Qian Jun 
Published: January 2023

Abstract
Necroptosis is a tightly regulated form of necrotic cell death that promotes inflammation and contributes to disease development. However, the potential roles of necroptosis-related genes (NRGs) in acute myeloid leukemia (AML) have not been elucidated fully. We conducted a study to identify a robust biomarker signature for predicting the prognosis and immunotherapy efficacy based on NRGs in AML. We analyzed the genetic and transcriptional alterations of NRGs in 151 patients with AML. Then, we identified three necroptosis clusters. Moreover, a necroptosis score was constructed and assessed based on the differentially expressed genes (DEGs) between the three necroptosis clusters. Three necroptosis clusters were correlated with clinical characteristics, prognosis, the tumor microenvironment, and infiltration of immune cells. A high necroptosis score was positively associated with a diverse prognosis, immune-cell infiltration, expression of programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1), immune score, stromal score, interferon-gamma (IFNG), merck18, T-cell dysfunction-score signatures, and cluster of differentiation-86, but negatively correlated with tumor immune dysfunction and exclusion (TIDE) score, myeloid-derived suppressor cells, and M2-type tumor-associated macrophages. Our observations indicated that a high necroptosis score might contribute to immune evasion. More interestingly, AML patients with a high necroptosis score may benefit from treatment based on immune checkpoint blockade. Consequently, our findings may contribute to deeper understanding of NRGs in AML, and facilitate assessment of the prognosis and treatment strategies.
In-Silico analysis of HAND subclass bHLH transcription factor in Cardiogenesis
Authors: Choudhury Shouhartha 
Published: January 2023

Abstract
Background: The HANDs are muscle-specific bHLH TFs crucial for proper cardiac and extra-embryonic development. The eHAND and dHAND functioned in developing ventricular chambers (right and left ventricle), aortic arch arteries, cardiac neural crest, endocardium and epicardium. The down-regulated response of the eHAND and dHAND genes reflects permissiveness. A recent report suggested that cardiac hypertrophy intimate eHAND corresponds to cardiomyopathy and dHAND in the atrium. Those reports supported the cardiac muscles may re-initiate a fetal gene result and initiate physiological changes, which allow the heart to recompense.
Objective: In this study, the objective is an investigation of the HAND subclass bHLH transcription factors in mammals. I like to classify the bHLH TFs and discuss the genetic evidence of both eHAND and dHAND genes in cardiogenesis. So, perform bioinformatics and computational tools and techniques to the current knowledge of the HAND subclass bHLH transcription factor in the mammalian genome. This application may be valuable for future functional analysis of particular TFs in different organisms.
Results: The observation data demonstrated that the heart and neural crest derivative transcription factors are present in mammals. The two mammalian genomes' likelihood of Homo sapiens and Mus musculus perform for comparative analysis. Analysis data suggested the eHAND and dHAND genes and a total number of bHLH domains in Homo sapiens and Mus musculus. Also, the conserved domain, motifs, phylogeny, gene expression and chromosome location analysis demonstrated the heart and neural crest derivative factors associated with cardiogenesis.
Conclusion: Over the last decades, a wealth of new reports has been composed of unique genetic and phenotypic characteristics of cardiac morphogenesis. The mutational analysis of the eHAND and dHAND transcription factors enabled precise resolution of specialized function during the developing myocardium. Also, analysis data concluded the muscle-specific transcription factors eHAND and dHAND are associated with cardiac disease and development. In contrast, the tissue-specific bHLH and other TFs lead to the development of myogenesis and vasculogenesis.
Development of negative soil feedback by an invasive plant near the northern limit of its invaded range
Authors: Zhang Vicki M. , Kotanen Peter M. 
Published: January 2023

Abstract

In the Canadian subarctic, the non-native plantLinaria vulgarishas invaded human-disturbed soils in and around the town of Churchill, Manitoba (58.8ºN), but for decades has failed to spread into nearby tundra and taiga communities. One possible explanation for this stasis might be greater resistance by soil communities in uninvaded areas relative to areas where this plant has been long established; however, no local evidence for such plant-soil feedbacks yet exists. In one of the first studies to investigate the role of plant-soil feedbacks in an invasion at high latitudes, we plantedL. vulgarisin soil serially inoculated with live and sterilized field-collected soil that was sampled either from invaded or uninvaded plots within anthropogenically-disturbed areas, and measured plant performance (biomass) over three greenhouse iterations. We also conducted basic soil chemical analyses to determine whether pH, and carbon, nitrogen, and phosphorous contents differ between invaded and uninvaded areas. There was no initial difference in plant biomass between soil inoculation treatments in the first two iterations. However, by iteration 3, we found that sterilization significantly increasedL. vulgarisbiomass in invaded soils, indicating feedback gradually becomes more negative in invaded soils compared to uninvaded soils. Soil chemistry did not differ significantly between invaded and uninvaded soils, though there was a tendency for invaded soils to contain slightly more carbon and nitrogen. These results reject the possibility thanL. vulgarisis absent from uncolonized sites because their soil communities resist invasion. Instead, they provide evidence thatL. vulgarisis inhibited by plant-soil feedbacks in invaded soils, while feedbacks in native-dominated soils do not represent a barrier to further local spread. Thus, explanations for the restriction of this species to anthropogenically modified areas must lie elsewhere.
Working after cancer: Psychological Flexibility and the quality of working life
Authors: Proctor Cecile J. , Reiman Anthony , Best Lisa A. 
Published: January 2023

Abstract
Purpose: Our purpose was to examine associations between the pillars of psychological flexibility (Valued Action, Behavioural Awareness, Openness to Experience) and aspects of quality of working life after a cancer. We examined how the pillars of psychological flexibility mediated relationships between quality of working life and anxiety, depression, and overall life satisfaction. Examining psychological flexibility allows interventions to be targeted for cancer survivors and account for unique, individual needs.
Methods In this cross-sectional study, 230 cancer survivors who were currently employed completed a questionnaire package that included demographic information and measures of Physical Health Problems, Satisfaction with Life, Quality of Working Life in Cancer Survivors, Psychological Flexibility, Anxiety, and Depression.
Results The mediational analyses illustrated how specific pillars of psychological flexibility mediated the relationships between quality of working life and anxiety, depression, and overall satisfaction with life. Overall, psychological flexibility mediated the relationships between physical health and health-related work problems, quality of working life, and satisfaction with life. Further, the Valued Action pillar of psychological flexibility fully mediated the relationship between Quality of Working Life and reported symptoms of depression and anxiety.
Conclusions:Higher psychological flexibility was related to higher satisfaction with working life. Physical and psychological challenges during employment may be improved through interventions that improve psychological flexibility. Actively engagement with activities aligned with personal values is related to more positive outcomes.
Implications for Cancer Survivors: The value of examining the pillars of psychological flexibility is that interventions can be targeted for this population, considering this population's unique needs.
The Impact of Continuous Positive Airway Pressure on Controlling Hypertension in Patients Diagnosed with Obstructive Sleep Apnea: An Observational Prospective Cohort study
Authors: Hamdan Alaa Ali Mohammed , Babiker Anas Bedawi , Alhag Omer Ali Mohammed , Ahmed Khabab Abbasher Hussien Mohamed 
Published: January 2023

Abstract

Background
Obstructive sleep apnea (OSA) is the most common type of sleep apnea and is caused by complete or partial obstructions of the upper airway. Evidence has consistently supported the association of obstructive sleep apnea syndrome with an increased prevalence of hypertension. Continuous positive airway pressure (CPAP) has a positive impact in the control of hypertension and so on, decreasing the cardiovascular risk and improving the quality of a patient's life. The aim of this study was to assess the impact of CPAP on controlling hypertension in patients with OAS.
Objectives
To study the impact of continuous positive airway pressure on controlling hypertension in patients having obstructive sleep apnea.
Methods
This was an observational comparative prospective cohort hospital-based study, covering 85 patients of OSA and hypertension presented to the cardiopulmonary department at Royal Care International Hospital; from December 2018 to December 2019. 40 of them received CPAP therapy while 45 did not.
Results
Of all participants 54.0% between 40–60 years, 59.8% were male, 60.3% had university level of education, and 49.1% were employee, 31.7% smoker, 5.8% tobacco snuffing, and 1.1% alcohol consumer. The mean body mass index (BMI) of the CPAP group was 37.3 ± 4.9, non-CPAP group 36.2 ± 3.9. The mean Epworth sleepiness scale (ESS) score of the CPAP group was 12.9, non-CPAP group 13.6.At the first visit; the mean systolic blood pressure (SBP) was 155.9 ± 12.4 mmHg, mean diastolic blood pressure(DBP) 95.3 ± 8.7 mmHg in CPAP group; while mean SBP 159.4 ± 11.6 mmHg; mean DBP 96.2 ± 7.1 mmHg in non-CPAP group. After one month, in CPAP group the mean SBP was 137 mmHg (-22 mmHg), mean DBP 83.8 mmHg (-11.5 mmHg), while in non-CPAP group the mean SBP was 148 mmHg (-11 mmHg), mean DBP 90.6 mmHg (-5.6 mmHg). After three months, in CPAP group the mean SBP was 131.6 mmHg (-5.4 mmHg), mean DBP was 79.5 mmHg (-4.3 mmHg), while in non-CPAP group the mean SBP 144.9 mmHg (-3.1 mmHg), mean DBP 85.1 mmHg (-5.5 mmHg). There is significant SBP reduction in the patients with severe OSA (P value 0.046) more than that in moderate OSA.
Conclusion
There was a significant reduction in both SBP & DBP in the CPAP group after one and three months. The difference of SBP reduction was higher in the patients with severe OSA (AHI > 30/h) more than those with moderate OSA (AHI 15–30/h). However, the difference of DBP reduction was not significantly correlated with AHI. Further research is required to know more about OSA and CPAP in our country.
A new taper off treatment of opium dependents can lead to cure the addiction as well as improvement of cognitive functions
Authors: Dezhakam Hossein , Dezhakam Amin , Dezhakam Shani , Haghighatfard Arvin 
Published: January 2023

Abstract
Opium is the dried latex obtained from the opium poppy. Opium addiction is the most prevalent addiction in Iranian society. During the last two decades "congress 60" a nongovernmental organization, has been performed a taper off treatment of opium associated with a package of psychological treatment group classes. Present study aimed to evaluate the effectiveness of taper off method in opium addiction in Iran, during more than 20 years as well as the effects of the treatment method on addiction associated cognitive dysfunctions.
In present study the taper off treatment method of opium addiction called Dezhakam step time (DST) were assessed. We used data collected via the congress 60 non-governmental organization in Iran dedicated to addiction treatment with DST method, since Jan 2018 until December 2020. In addition, executive functions including memory and decision making were analyzed in a large sample size from addicted subjects which were successfully treated with DST method in Congress 60.
Results showed high number of successful treatment of opium addiction and very low number of substance abuse relapse. Also, significant improvements in memory and decision making were determined in addicts after therapy and these improvements were correlated with duration of individuals' membership in congress 60.
Findings revealed the effectiveness of taper off method in treatment of opium addiction as well as improvement in cognitive functions in opium dependent persons. Findings of the study may help to a better understanding from a novel method of opium addiction treatment called DST and its effects on neuropsychological mechanisms and brain functions of opium dependents.
Laparoscopic Proximal Gastrectomy with Right-Sided Overlap and Single-Flap Valvuloplasty (ROSF): A Case-Series Study
Authors: Peng Wei , Yan Shangcheng , Huang Yikai , Cheng Ming , Liu Tianhua , Ren Rui , Chen Qiang , Zhang Jingyu , Gong Wei , Xing Chungen , Wu Yongyou 
Published: January 2023

Abstract
Background
There is no standard reconstruction method following proximal gastrectomy, of which gastroesophageal reflux and anastomotic complications are of great concern. Though several techniques have been devised to overcome these postoperative complications, such as double tract reconstruction, double-flap technique and side overlap fundoplication by Yamashita, none of them is considered a perfect solution. Herein, we designed a novel method of esophagogastrostomy after laparoscopic proximal gastrectomy (LPG), named right-sided overlap and single-flap valvuloplasty (ROSF).
Methods
Between March 2021 and December 2021, 20 consecutive patients underwent LPG-ROSF at Department of Gastrointestinal Surgery, Second Affiliated Hospital of Soochow University. Surgical outcomes and postoperative complications were recorded. Endoscopy and assessment of gastrointestinal symptoms were performed 1 year after surgery. Nutrition-related parameters including total body weight, hemoglobin, lymphocyte count, serum total protein, serum albumin and serum prealbumin were evaluated 1 year after surgery and compared with those before surgery.
Results
The mean surgery time and anastomosis time was 285.3 ± 71.3 and 61.3 ± 11.2 min respectively. None of the patients had gastrointestinal early postoperative complications. Symptomatic reflux was observed in one patient (5%) while reflux esophagitis (Los Angeles Grade A) was observed in another patient (5%). Four patients (20%) had mild dysphagia (Visick score = II) but none of them had anastomotic stenosis. There were no significant changes in nutritional status postoperatively.
Conclusions
ROSF can be safely performed after LPG and has satisfactory outcomes in preventing reflux and stenosis, and maintaining nutritional status. This technique requires further validation.
Mechanism of action of Rougan Huaxian granules in the regulation of mitochondrial autophagy and inhibition of hepatic stellate cell activation
Authors: Wenfu Zhang , Lei Yang , Ming Dai , Jianlin Lv , Jingjing Huang , Xiaolong Li , Shanshan Wu , Zhenchang Wang 
Published: January 2023

Abstract
Rougan Huaxian granules (RH-gs) can reverse liver fibrosis. However, their mechanism of action remains unknown. We aimed to explore the mechanism of action and effects of RH-gs on the inhibition of activation and proliferation of hepatic stellate cells (HSCs) by regulation of mitochondrial autophagy. Using real-time PCR, western blot, and ELISA assays, we measured the mRNA and protein levels of TGF-β1, NF-κB p65, p-NF-κB p65, α-SMA, type I collagen, type III collagen, TNF-α, FOXO1, PINK1, Parkin, LC3Ⅱ, Smad2, and p-Smad2 in the HSC-T6 cells post RH-gs-treatment. Mitochondrial membrane potential (MMP) and ROS production were detected using flow cytometry. Our H2O2-induced cellular oxidative stress HSC-T6 model showed that the miR-135a, α-SMA, type Ⅰ collagen, type Ⅲ collagen, TNF-α, p-NF-κB p65, p-Smad2, and TGF-β1 expression and ROS generation was significantly increased, which causes liver fibrosis and inflammation. The FOXO1, PINK1, Parkin, MMP decline rate and LC3 II expression was downregulated, indicating that oxidative stress can inhibit mitochondrial autophagy. The treatment with RH-gs showed significant inhibition of the effects of H2O2. RH-gs can inhibit the activation of HSCs, and its mechanism is associated with the inhibition of miR-135a expression and activation of the FOXO1/PINK1 pathway, which promotes mitochondrial autophagy. So, this study can provide theoretical basis for the treatment of liver fibrosis with RH-gs.
Diagnostic value of qualitative and quantitative parameters of contrast-enhanced ultrasound for differentiating thyroid carcinoma nodules from benign thyroid nodules
Authors: Fan Jinfang , Zhou Wei , Tao Lingling , Zhan Weiwei , Li Weiwei , Kuang Lijun , Zhao Yingyan 
Published: January 2023

Abstract

Objective To explore the diagnostic value of qualitative and quantitative parameters of contrast-enhanced ultrasound (CEUS) for differentiating thyroid carcinoma nodules and benign thyroid nodules. Method The qualitative and quantitative CEUS parameters of 290 thyroid nodules confirmed by pathology were analyzed retrospectively. The evaluation indexes included wash in, wash out, enhancement degree, enhancement homogeneity, morphology after angiography, and ring enhancement. Results Malignant nodules had an unclear margin, uneven perfusion, and low perfusion (all p < 0.05). The internal peak of malignant nodules was lower than that of benign nodules, the TP at the outer edge of malignant nodules was higher than that of benign nodules, the sharpness at the outer edge of malignant nodules was lower than that of benign nodules, and the AUC at the outer edge of malignant nodules was lower than that of benign nodules (all p < 0.05). Multivariate analysis showed that internal peak and external sharpness were independent risk factors for the diagnosis of differentiated thyroid carcinoma and benign thyroid nodules. Conclusion The qualitative and quantitative analysis of CEUS can provide valuable information for the differential diagnosis of differentiated thyroid carcinoma (DTC) and benign thyroid nodules.
The theoretical model of the effective strain establishment for the plate during the snake rolling
Authors: Yang Ruowen , Jiang Lian-yun , Yang Ruo-wen , Xue Zhi-wei , Ma Qi-qi , Huang Zhi-quan 
Published: January 2023

Abstract
The snake rolling for the heavy plate rolling has been verified that it can refine the grain and solve the problem of insufficient deformation in the center of the plate to some extent. The effective strain along the thickness is mainly obtained by the finite element method and the experiments which cost a long time and great material resources. A theoretical model of the effective strain is required to solve the problem. The metal flow model including the shear deformation is established according to the actual asymmetric distribution of stress and strain in the deformation zone. The parabolic roll gap inlet boundary equation is proposed according to the kinematic characteristics of plate rolling. The plastic deformation power, shear power and friction power models are established according to the first variational principle of the rigid plasticity and the principle of virtual velocity. The analytic model to calculate the effective strain of the snake rolling has been established by the principle of minimum energy and the theory of continuum mechanics. The model accuracy has also been verified by the finite element method and the experiments. The minimum and the maximum relative error is 1.33% and 13.44% which is acceptable for industrial applications. This research will provide an important guidance for the process and process parameters setup.
Unexplained Hypoxia in Patient With Aortic Valve Replacement: Case of Hepatopulmonary Syndrome With Delayed Diagnosis
Authors: Kodal Burcu , Adak Oğulcan , Kutlu Merih , Örem Cihan , Akkaya Selçuk 
Published: January 2023

Abstract
Hepatopulmonary syndrome (HPS) is a pulmonary complication that causes deterioration in oxygenation due to the inability to clear substances that will cause intrapulmonary vasodilation in advanced liver disease and the increase in vasodilator substances released from the liver (1). Hepatopulmonary syndrome may be misdiagnosed because of nonspecific symptoms and other comorbidities. There is no optimal medical therapy. However, the best treatment option is liver transplantation to improve oxygenation and survival (2) . We aimed to present a 44-year-old patient with a delayed diagnosis of HPS who had significant dyspnea and cyanosis and undergone cardiac surgery twice.