bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion-weighted imaging complements T2-weighted MRI for tumour response assessment in squamous anal carcinoma
Authors: Prezzi Davide , Muthuswamy Keerthini , Amlani Ashik , Owczarczyk Kasia , Elowaidy Ahmed , Mistry Tina , Bassett Paul , Goh Vicky 
Published: July 2023

Abstract
Objectives
A published tumour regression grade (TRG) score for squamous anal carcinoma treated with definitive chemoradiotherapy based on T2-weighted MRI yields a high proportion of indeterminate responses (TRG-3). We investigate whether the addition of diffusion-weighted imaging (DWI) improves tumour response assessment in the early post treatment period.

Materials and methods
This retrospective observational study included squamous anal carcinoma patients undergoing MRI before and within 3 months of completing chemoradiotherapy from 2009 to 2020. Four independent radiologists (1–20 years’ experience) scored MRI studies using a 5-point TRG system (1 = complete response; 5 = no response) based on T2-weighted sequences alone, and then after a 12-week washout period, using a 5-point DWI-TRG system based on T2-weighted and DWI. Scoring confidence was recorded on a 5-point scale (1 = low; 5 = high) for each reading and compared using the Wilcoxon test. Indeterminate scores (TRG-3) from each reading session were compared using the McNemar test. Interobserver agreement was assessed using kappa statistics.

Results
Eighty-five patients were included (mean age, 59 years ± 12 [SD]; 55 women). T2-weighted TRG-3 scores from all readers combined halved from 24% (82/340) to 12% (41/340) with DWI (p < 0.001). TRG-3 scores changed most frequently (41%, 34/82) to DWI-TRG-2 (excellent response). Complete tumour response was recorded clinically in 77/85 patients (91%). Scoring confidence increased using DWI (p < 0.001), with scores of 4 or 5 in 84% (287/340). Interobserver agreement remained fair to moderate (kappa range, 0.28–0.58).

Conclusion
DWI complements T2-weighted MRI by reducing the number of indeterminate tumour responses (TRG-3). DWI increases radiologist’s scoring confidence.

Clinical relevance statement
Diffusion-weighted imaging improves T2-weighted tumour response assessment in squamous anal cancer, halving the number of indeterminate responses in the early post treatment period, and increases radiologists’ confidence.

Key Points

Tumour response based on T2-weighted MRI is often indeterminate in squamous anal carcinoma.

Diffusion-weighted imaging alongside T2-weighted MRI halved indeterminate tumour regression grade scores assigned by four radiologists from 24 to 12%.

Scoring confidence of expert and non-expert radiologists increased with the inclusion of diffusion-weighted imaging.
‘The poetry of psychiatry’: existential analysis and the politics of psychopathology in Franco’s Spain
Authors: Novella Enric J. 
Published: July 2023

AbstractThis article examines the presence and influence of the work of Swiss psychiatrist Ludwig Binswanger and existential analysis (Daseinsanalyse) in Spanish psychiatry in the central decades of the 20th century. First, and drawing on various printed and archival sources, it reconstructs the important personal and professional ties that Binswanger maintained with numerous Spanish colleagues and describes the notable dissemination of his work in Spain through bibliographical reviews, scientific events, academic reports, university lectures and translations. Next, it reviews the incorporation of the postulates of existential analysis into the discourse of Spanish psychiatrists and assesses their most elaborate and original contributions to the foundations of ‘anthropological–existential’ psychiatry or the ‘existential–analytical’ interpretation of certain disorders or clinical conditions. And, finally, it tries to clarify the assessment according to which the (inevitable) instrumentalisation of existential analysis in the context of Franco’s Spain first compromised the critical recognition of its true possibilities (and limits) and later contributed to the discrediting of psychopathological research among Spanish psychiatrists.
Comparison of intranasal medication delivery devices before and after functional endoscopic sinus surgery using Phacon sinus surgery models
Authors: Constantinou Christoforos , Yap Darren , Pervaiz Arbaaz , Bandino Fabrizio , Jeyaretna Sanjeeva , Martinez-Devesa Pablo , Qureishi Ali 
Published: July 2023

AbstractObjectiveFunctional endoscopic sinus surgery for chronic rhinosinusitis improves sinus drainage and intranasal medication delivery. This study compares medication delivery with commonly used devices in normal and altered anatomy (post functional endoscopic sinus surgery) using sinus surgery models (Phacon).MethodsMedication delivery was simulated via nasal drops, nasal spray and an irrigation device (Neilmed Sinus Rinse). Coverage was then calculated from endoscopic pictures taken at various anatomical sites in the normal nose and post functional endoscopic sinus surgery.ResultsIn the normal nose, nasal spray did not penetrate the sphenoid sinus, and drops bypassed the vestibule anteriorly. Neilmed Sinus Rinse provided superior coverage at the sphenoid site following sphenoidectomy and the frontal site following Draf III. After ethmoidectomy, nasal drops overall provided less coverage than the other methods.ConclusionNeilmed Sinus Rinse generally provided the best distribution, followed by the nasal spray and then nasal drops. The type and extent of surgery also affects medication delivery.
The dual-system approach is a useful heuristic but does not accurately describe behavior
Authors: Sherman Jeffrey W. , Klein Samuel A. W. 
Published: July 2023

Abstract
We argue that the dual-system approach and, particularly, the default-interventionist framework favored by De Neys unnecessarily constrains process models, limiting their range of application. In turn, the accommodations De Neys makes for these constraints raise questions of parsimony and falsifiability. We conclude that the extent to which processes possess features of system 1 versus system 2 must be tested empirically.
Sprint Cycling
Authors: Dale Julian , Muniz-Pumares Daniel , Cimadoro Giuseppe , Meijen Carla , Glaister Mark 
Published: July 2023

Abstract: The time between races varies in the track cycling competition known as the Match Sprint but can be as little as 10–15 min. Both physiological and motivational factors could affect performance recovery. This study investigated how the between-sprint recovery activity, and an alteration in the duration of the second sprint, affected performance. Twenty-four strength-trained men (age: 26 ± 5 years; height: 180.3 ± 6.1 cm; body mass: 82.3 ± 6.9 kg) participated. During each of the four experimental trials, two sprints were performed 12 min apart. The first was always 18 s and the second was either 9 s or 18 s. Between sprints, passive rest or a mixture of active and passive recovery was undertaken. Peak power output (PPO), as well as mean power output over 9 s (MPO9) and 18 s (MPO18), was recorded. Lactate concentration, ratings of sprint preparation and performance, as well as perceptions of recovery, were also measured. Post-trial and post-study questionnaires explored factors that may have influenced performance. A sprint number × recovery method interaction, F(1, 23) = 28.791, p < .001, ηp2 = .556, was found for PPO, with a significantly lower PPO in sprint 2 following passive recovery. Sprint number × second sprint duration interactions were found for PPO, F(1, 23) = 9.867, p = .005, ηp2 = .300, and MPO9, F(1, 23) = 8.922, p = .007, ηp2 = .279. A significant time × condition interaction was also found for lactate concentration, F(6.082, 97.320) = 2.982, p = .010, ηp2 = .157, although post hoc tests were unable to identify the cause of any of these effects. Typically, the participants were satisfied with their sprint performances and expressed positive views about the recovery activity undertaken. The main finding was, therefore, that PPO was lower following passive recovery, but the effects on MPO were not apparent.
A First Examination of the Link Between Heart Rate Variability and Networks of Anxiety and Depression Symptoms
Authors: Verkuil Bart , Wekenborg Magdalena K. 
Published: July 2023

Abstract: The neurovisceral integration model proposes that people low in heart rate variability (HRV) are in a state with strong connections between symptoms of anxiety and depression. So far studies providing support for this hypothesis have relied on classifications or sum scores of a diverse range of symptoms, ignoring observations that anxiety and depression symptoms dynamically influence each other. Here we used network analyses to study if HRV moderates characteristics (density, structure, centrality indices) of network models of generalized anxiety disorder and depression symptoms. We used data ( N = 495) from the Dresden Burnout Study where resting levels of HRV were obtained as well as self-reported symptoms of generalized anxiety and depression. Results showed that HRV did not moderate the density and structure of the overall symptom networks. Exploration of the centrality indices suggested that restlessness was a more central node for people low in HRV, a result that remains to be confirmed in larger samples. These findings demonstrate how a network perspective may aid in better understanding the complex relation between symptoms of psychopathology and physiological status.
Regional Impact of Snow‐Darkening on Snow Pack and the Atmosphere During a Severe Saharan Dust Deposition Event in Eurasia
Authors: Rohde Anika , Vogel Heike , Hoshyaripour Gholam Ali , Kottmeier Christoph , Vogel Bernhard 
Published: July 2023

AbstractLight‐absorbing impurities such as mineral dust can play a major role in reducing the albedo of snow surfaces. Particularly in spring, deposited dust particles lead to increased snow melt and trigger further feedbacks at the land surface and in the atmosphere. Quantifying the extent of dust‐induced variations is difficult due to high variability in the spatial distribution of mineral dust and snow. We present an extension of a fully coupled atmospheric and land surface model system to address the impact of mineral dust on the snow albedo across Eurasia. We evaluated the short‐term effects of Saharan dust in a case study. To obtain robust results, we performed an ensemble simulation followed by statistical analysis. Mountainous regions showed a strong impact of dust deposition on snow depth. We found a mean significant reduction of −1.4 cm in the Caucasus Mountains after 1 week. However, areas with flat terrain near the snow line also showed strong effects despite lower dust concentrations. Here, the feedback to dust deposition was more pronounced as increase in surface temperature and air temperature. In the region surrounding the snow line, we found an average significant surface warming of 0.9 K after 1 week. This study shows that the impact of mineral dust deposition depends on several factors. Primarily, these are altitude, slope, snow depth, and snow cover fraction. Especially in complex terrain, it is therefore necessary to use fully coupled models to investigate the effects of mineral dust on snow pack and the atmosphere.
Topographic Drivers of Soil Moisture Across a Large Sensor Network in the Southern Appalachian Mountains (USA)
Authors: Stark Jordan R. , Fridley Jason D. 
Published: July 2023

AbstractUnderstanding the distribution of soil moisture is notoriously difficult in topographically complex regions that are subject to both large‐scale climate gradients and fine‐scale effects of terrain, vegetation, and soil structure. Remote sensing approaches capture large‐scale moisture patterns but are limited in spatial and temporal resolution, while commercial field sensors remain too expensive to deploy intensively over large spatial extents. Here, we demonstrate the use of low‐cost (<20 USD) custom sensors to create a large monitoring network of surficial (0–15 cm depth) volumetric soil moisture content (VMC) across Great Smoky Mountains National Park (GSMNP) (NC, TN, USA). In laboratory tests, temperature‐calibrated VMC values approached the accuracy of commercial probes. We deployed over 80 sensors across multiple watersheds, topographic positions, and a 1,800‐m elevation gradient, and created hierarchical models to understand associations of VMC with spatial (30‐m resolution) and temporal (daily) variables related to water supply and demand. Elevation had the strongest association with VMC, with a fivefold increase across the gradient reflecting 1.5‐fold changes in both (increased) precipitation and (decreased) evapotranspiration; slope angle was a strong mediating factor. Common proxies for moisture including topographic convergence index were not associated with VMC, likely due to limited contributions of surface drainage to local water balance. Our model predicted daily VMC of a set of validation sensors with a root mean square error of 4.8%, which may be improved by site‐specific field calibration. Our study indicates that spatially extensive, field‐based soil moisture networks are practical, accurate, and an important component of regional environmental monitoring.
An extraordinary fossil captures the struggle for existence during the Mesozoic
Authors: Han Gang , Mallon Jordan C. , Lussier Aaron J. , Wu Xiao-Chun , Mitchell Robert , Li Ling-Ji 
Published: July 2023

AbstractDinosaurs and mammals have coexisted for the last ~ 230 million years. Both groups arose during the Late Triassic and diversified throughout the Mesozoic and into the Cenozoic (the latter in the form of birds). Although they undoubtedly interacted in many ways, direct fossil evidence for their interaction is rare. Here we report a new fossil find from the Lujiatun Member of the Lower Cretaceous Yixian Formation of China, showing a gobiconodontid mammal and psittacosaurid dinosaur locked in mortal combat. We entertain various hypothesized explanations for this association, but the balance of the evidence suggests that it represents a predation attempt on the part of the smaller mammal, suddenly interrupted by, and preserved within, a lahar-type volcanic debris flow. Mesozoic mammals are usually depicted as having lived in the shadows of their larger dinosaurian contemporaries, but this new fossil convincingly demonstrates that mammals could pose a threat even to near fully-grown dinosaurs. The Yixian Formation—and the Chinese fossil Jehol Biota more broadly—have played a particularly important role in revealing the diversity of small-bodied dinosaurs and other fauna. We anticipate that the volcanically derived obrution deposits specific to the Lujiatun Member will likewise continue to yield evidence for biotic interactions otherwise unknown from the rest of the fossil record.
Factors influencing gender preference towards surgeons among Jordanian adults: an investigation of healthcare bias
Authors: AlSamhori Jehad Feras , Rayyan Rama , Hammouri Muhammad , Taha Hana , Al-Huneidy Leen , AlOweiwi Wahid , AlMohtasib Jamil , Mansour Shahd , Dardas Majid , Qiqieh Jamil , Halasa Zeina , Al-Huneidy Yazan , Al-Ani Abdallah 
Published: July 2023

AbstractStudies investigating gender bias against female surgeons yielded conflicting results ranging from neutrality to a clear preference towards male surgeons. Yet, such bias remains understudied within Middle Eastern nations. We aimed to assess preferences of surgeons’ gender among Jordanians and explore reasons for possible gender bias across different surgical specialties. A total of 1708 respondents were examined using a cross-sectional, self-administered questionnaire to evaluate the gender preferences of surgeons, characteristics associated with preferred surgeon’s gender, and surgeon’s preference in certain specialties. Nearly 52.0% of participants had no gender preference for surgeons. Among those with a preference, 75.7% preferred male surgeons while 24.3% preferred female surgeons. Reputation, knowledge, and experience were the most important factors when choosing a surgeon. Male surgeons were viewed as more trustworthy, knowledgeable, experienced, and communicative. Female surgeons were dominantly perceived as more compassionate, cooperative, and prone to listen. Male respondents were 5 times more likely to choose a surgeon of similar gender (OR 5.687; CI 3.791–8.531). Male surgeons were favored for cardiovascular and orthopedic surgeries. Similarly, female surgeons were favored in gynecological and obstetric surgeries, plastic surgeries, and breast surgeries. Female gender (OR 6.193; CI 4.077–9.408), living outside Amman (OR 1.517; CI 1.066–2.160), and being married (OR 2.504; CI 1.601–3.917) were all significant positive predictors of preferring female surgeons. Our findings highlight differences in gender preference and perception of surgeons among Jordanian adults.
Identification of bromelain subfamily proteases encoded in the pineapple genome
Authors: Yow Ashley G. , Bostan Hamed , Young Roberto , Valacchi Giuseppe , Gillitt Nicholas , Perkins-Veazie Penelope , Xiang Qiu-Yun , Iorizzo Massimo 
Published: July 2023

AbstractPapain (aka C1A) family proteases, including bromelain enzymes, are widespread across the plant kingdom and play critical regulatory functions in protein turnover during development. The proteolytic activity exhibited by papain family proteases has led to their increased usage for a wide range of cosmetic, therapeutic, and medicinal purposes. Bromelain enzymes, or bromelains in short, are members of the papain family that are specific to the bromeliad plant family. The only major commercial extraction source of bromelain is pineapple. The importance of C1A family and bromelain subfamily proteases in pineapple development and their increasing economic importance led several researchers to utilize available genomic resources to identify protease-encoding genes in the pineapple genome. To date, studies are lacking in screening bromelain genes for targeted use in applied science studies. In addition, the bromelain genes coding for the enzymes present in commercially available bromelain products have not been identified and their evolutionary origin has remained unclear. Here, using the newly developed MD2 v2 pineapple genome, we aimed to identify bromelain-encoding genes and elucidate their evolutionary origin. Orthologous and phylogenetic analyses of all papain-family proteases encoded in the pineapple genome revealed a single orthogroup (189) and phylogenetic clade (XIII) containing the bromelain subfamily. Duplication mode and synteny analyses provided insight into the origin and expansion of the bromelain subfamily in pineapple. Proteomic analysis identified four bromelain enzymes present in two commercially available bromelain products derived from pineapple stem, corresponding to products of four putative bromelain genes. Gene expression analysis using publicly available transcriptome data showed that 31 papain-family genes identified in this study were up-regulated in specific tissues, including stem, fruit, and floral tissues. Some of these genes had higher expression in earlier developmental stages of different tissues. Similar expression patterns were identified by RT-qPCR analysis with leaf, stem, and fruit. Our results provide a strong foundation for future applicable studies on bromelain, such as transgenic approaches to increase bromelain content in pineapple, development of bromelain-producing bioreactors, and studies that aim to determine the medicinal and/or therapeutic viability of individual bromelain enzymes.
Frame recovery using multiple images in rolling shutter based systems
Authors: Rêgo Miguel , Perez Joaquin , Fonseca Pedro , Alves Luís Nero 
Published: July 2023

AbstractAn algorithm for recovering transmitted static identifiers (IDs) in rolling shutter based Optical Camera Communication systems is proposed by the authors, considering a system comprised of a camera and a circular light source. The goal is to allow the correct decoding when the ID frame is only partially detected in the image. A baseline algorithm as reference for the frame recovery success rate (FRSR) and a reconstruction algorithm based on the idea of capturing multiple frame fragments and reassembling them is proposed in order to recover the transmitted ID not entirely seen on a single image. It was proven, by simulation, that the maximum distance at which the IDs recovery can be guaranteed is increased by 2.5 fold with the proposed algorithm, for 6‐bit, 8‐bit and 10‐bit codewords. An experimental validation algorithm was also proposed, using image processing techniques to extract the bitstreams and test the ID recovery process. The proposed algorithm improves the FRSR for a given distance, even in the presence of considerable bit errors in the bitstreams extracted from the images.
Reconfigurable high step‐up DC to DC converter for microgrid applications
Authors: Tewari Nilanjan , Paul Nilanjan , Jayaraman Meenakshi , Prabhakar Mahalingam 
Published: July 2023

AbstractHere, a high gain DC–DC converter which is based on switched capacitor (SC) and switched LCL (SLCL) cells is presented. The diode employed in the classical passive switched inductor (SI) cell is replaced by a capacitor in the proposed SLCL cell to achieve higher voltage gain. Two switches—one each in the positive and negative DC rails of the supply are employed to charge and discharge the inductors of SLCL cells. A generic structure comprising of N and M number of SLCL cells in the positive and negative DC rails respectively along with K number of SC cells is presented. To validate the proposed gain extension concept, a two‐switch based converter comprising of 2 SLCL and 1 SC cells is synthesized and its operation is described in detail. The voltage gain expression of the proposed SLCL‐SC converter is derived. Experimental results are obtained from a 25 to 380 V prototype converter which operates at a full‐load efficiency of 94.22% at 200 W. Since the switches employed in the proposed converter are operated at a moderate and safe duty ratio of D = 0.51, the voltage stress on the switches is about 25% of the output voltage while the diodes are subjected to even lesser voltage stress levels of only one‐fifth of the output voltage. The main salient features of the proposed topology are its (i) modular structure, (ii) ability to provide higher voltage gain values at lower duty ratios (iii) reduced voltage stress on the semiconductor devices and (iv) reduced conduction losses due to the replacement of diodes with capacitors in SLCL cells.