bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the effect of Alpinia galanga extract on the treatment of SSRI-induced erectile dysfunction: A randomized triple-blind clinical trial
Authors: Akbarzadeh Farzad , Eslamzadeh Mahboubeh , Behravan Ghazal , Ebrahimi Alireza , Emami Seyed Ahmad , Gilan Atefe , Hoseinian Najme Sadat 
Published: April 2023

ObjectiveSSRIs are considered the first line in the medical treatment of depression and anxiety disorders. One of their most common side effects, sexual dysfunction, has led many patients to discontinuing their medication and treatment course. Alpinia galanga, a plant from the ginger family, has been shown to enhance androgenic activity and sexual function. This study aimed to assess whether the addition of Alpinia galanga extract to the treatment regimen of adult males consuming SSRIs can improve SSRI-induced erectile dysfunction.Materials and methodsThis triple-blind randomized clinical trial was conducted on 60 adult males who were being treated with SSRIs at the time of the study. The participants were divided into two groups, a group of 30 people receiving 500 mg of Alpinia galanga extract and a group of 30 subjects receiving placebo. The population were re-assessed on week 2 and week 4 of the study using the international index of erectile function (IIEF), the Beck Depression Inventory, and the Beck Anxiety Inventory. In all the tests, a p-value of 0.05 was considered as the cut-off for significance.ResultsAt the beginning of the study, the IIEF scores of the placebo group and the intervention group were 10.6 ± 3.8 and 11.2 ± 4.8, respectively, which were not significantly different (p-value = 0.577). By week 4 of the study, the IIEF scores of the control group and the Alpinia galanga group had increased to 13.7 ± 4.3 and 17.4 ± 3.7 respectively, which demonstrates a remarkably larger increase in the group receiving Alpinia galanga extract in comparison to the placebo group (p-value &lt; 0.001).ConclusionIn this study, the effect of the addition of Alpinia galanga extract to the treatment regimen of male patients using SSRIs on the sexual dysfunction experienced by this group has been promising. Similar results, if proven, can aid both patients and clinicians in making and following better treatment plans with more pleasant outcomes.Clinical trial registration[https://clinicaltrials.gov/], identifier [IRCT20101130005280N41].
Trends in economic burden of type 2 diabetes in China: Based on longitudinal claim data
Authors: Liu Xinyi , Zhang Luying , Chen Wen 
Published: April 2023

ObjectiveDiabetes is a major health issue in China that has a significant economic burden on society. Understanding the economic impact of diabetes can help policymakers make informed decisions about healthcare spending and priorities. This study aims to estimate the economic burden of patients with diabetes in an urban setting in China and to identify the impact of hospitalization and complications on health care costs for people with diabetes.MethodsThe study was conducted in a sample city located in eastern China. All patients diagnosed with diabetes before January 2015 were identified from the official health management information system, and their social demographics and records of their health care uses and costs were extracted from the claim database from 2014 to 2019. Six groups of complications were identified according to ICD-10 codes. The diabetes-related direct medical cost (DM cost) was described for patients in stratified groups. A multiple linear regression model was applied to identify the effect of hospitalization and complications on the DM cost of diabetic patients.ResultsOur research included 44,994 patients with diabetes, the average annual DM costs for diabetic patients increased from 1,292.72 USD in 2014 to 2,092.87 USD in 2019. The costs of diabetes are closely related to hospitalizations and the type and number of complications. The average annual DM cost of patients who were hospitalized was 2.23 times that of those without hospitalization, and it rose as the number of complications increased. Cardiovascular complications and nephropathic complications were the complications that had the greatest impact on patients’ DM costs, increasing by an average of 65 and 54%, respectively.ConclusionThe economic burden of diabetes in urban China has increased significantly. Hospitalization and the type and number of complications have significant impacts on the economic burden of patients with diabetes. Efforts should be made to prevent the development of long-term complications in the population with diabetes.
Impact of free hypertension pharmacy program and social distancing policy on stroke: A longitudinal study
Authors: Zhou Qi , Yu Meihua , Jin Meihua , Zhang Peng , Qin Guoyou , Yao Ye 
Published: April 2023

BackgroundThe estimated lifetime risk of stroke was the highest in East Asia worldwide, especially in China. Antihypertensive therapy can significantly reduce stroke mortality. However, blood pressure control is poor. Medication adherence is a barrier as patients’ out-of-pocket costs have risen. We aimed to take advantage of a free hypertension pharmacy intervention and quantified the impact on stroke mortality.MethodsA free pharmaceutical intervention program was implemented in Deqing, Zhejiang province in April 2018. Another non-pharmaceutical intervention, social distancing due to the pandemic of Coronavirus disease 2019 (COVID-19), was also key to affecting stroke mortality. We retrospectively collected the routine surveillance data of stroke deaths from Huzhou Municipal Center for Disease Prevention and Control in 2013–2020 and obtained within-city mobility data from Baidu Migration in 2019–2020, then we quantified the effects of both pharmaceutical intervention and social distancing using Serfling regression model.ResultsCompared to the predicted number, the actual number of stroke deaths was significantly lower by 10% (95% CI, 6–15%; p &lt; 0.001) from April 2018 to December 2020 in Deqing. Specifically, there was a reduction of 19% (95% CI, 10–28%; p &lt; 0.001) in 2018. Moreover, we observed a 5% (95% CI, −4 – 14%; p = 0.28) increase in stroke mortality due to the adverse effect of COVID-19 but it wasn’t statistically significant.ConclusionFree hypertension pharmacy program has great potential to prevent considerable stroke deaths. In the future, the free supply of low-cost, essential medications that target patients with hypertension at increased risk of stroke could be taken into account in formulating public health policies and guiding allocations of health care resources.
uRP: An integrated research platform for one-stop analysis of medical images
Authors: Wu Jiaojiao , Xia Yuwei , Wang Xuechun , Wei Ying , Liu Aie , Innanje Arun , Zheng Meng , Chen Lei , Shi Jing , Wang Liye , Zhan Yiqiang , Zhou Xiang Sean , Xue Zhong , Shi Feng , Shen Dinggang 
Published: April 2023

IntroductionMedical image analysis is of tremendous importance in serving clinical diagnosis, treatment planning, as well as prognosis assessment. However, the image analysis process usually involves multiple modality-specific software and relies on rigorous manual operations, which is time-consuming and potentially low reproducible.MethodsWe present an integrated platform - uAI Research Portal (uRP), to achieve one-stop analyses of multimodal images such as CT, MRI, and PET for clinical research applications. The proposed uRP adopts a modularized architecture to be multifunctional, extensible, and customizable.Results and DiscussionThe uRP shows 3 advantages, as it 1) spans a wealth of algorithms for image processing including semi-automatic delineation, automatic segmentation, registration, classification, quantitative analysis, and image visualization, to realize a one-stop analytic pipeline, 2) integrates a variety of functional modules, which can be directly applied, combined, or customized for specific application domains, such as brain, pneumonia, and knee joint analyses, 3) enables full-stack analysis of one disease, including diagnosis, treatment planning, and prognosis assessment, as well as full-spectrum coverage for multiple disease applications. With the continuous development and inclusion of advanced algorithms, we expect this platform to largely simplify the clinical scientific research process and promote more and better discoveries.
Soil bacterial community structure at different plant maturity stages in an annual grass–legume production system
Authors: Xie Yixiao , Liu Wen , Li Ping , Bai Shiqie , Li Daxu , Zhang Lixia , Sun Hong , Zheng Yulong , Cheng Qiming , Wang Chunmei , Du Ermei , Gou Wenlong 
Published: April 2023

IntroductionTo infer changes in soil function and thus determine appropriate agronomic management practices, this study evaluated the effects of plant maturity stage on root characteristics, soil chemical and enzymatic properties, and soil bacterial community composition in an annual grass–legume production system.MethodsAnnual ryegrass or rye was sown in combination with one of three legume species at a legume ratio of 50%. Eighteen plots (six plant combinations, three replicates per combination, 20 m × 25 m plots) were tilled to a depth of 20 cm after mowing. Soil samples from each plot were collected on four dates as the plants matured: January 4 (H1), March 14 (H2), April 21 (H3), and May 19 (H4). Bacterial community structures were characterized via 16S rRNA high-throught sequencing and the bio-informatics methods were used to evaluate the structural characteristics of soil bacteria.ResultsThe most abundant root growth was observed at the H3 stage. No significant differences in organic matter, alkali-hydrolyzable nitrogen, available phosphorus, and available potassium contents (p &gt; 0.05) were observed on any sampling date. Soil collected at the H3 stage exhibited lower acid protease and urease activities (p &lt; 0.05) and higher nitrate reductase activity (p &lt; 0.05). The structure of the microbial community at stage H3 differed markedly from that at other stages, as evidenced by a higher abundance of Proteobacteria, Bacteroidetes, Acidobacteria, and Verrucomicrobia (p &lt; 0.05) and a lower abundance of Actinobacteria, Cyanobacteria, and Planctomycetes (p &lt; 0.05). At the class level, the relative abundances of Sphingobacteria, Betaproteobacteria, and Gammaproteobacteria in soil was higher at H3 stage than those of other stages (p &lt; 0.05). The order level for Sphingomonadales, Sphingobacteriales, and Burkholderiales and at the family level for Chitinophagaceae and Sphingomonadaceae showed the same trend toward higher.ConclusionNutrient cycling in the soil was slowed at the H3 stage, and the loss of nitrogen would also be greater. Measures may need to be taken to improve the nitrogen fertilizer utilization efficiency to reduce denitrification and nitrous oxide production at this stage (the booting stage of grasses and budding stage of legumes).
Safety and efficacy of microwave ablation for abdominal wall endometriosis: A retrospective study
Authors: Liu Yujiang , Wen Wanwan , Qian Linxue , Xu Ruifang 
Published: April 2023

ObjectivesThis retrospective study aimed to evaluate the safety and feasibility of ultrasound-guided microwave ablation in the treatment of abdominal wall endometriosis (AWE).BackgroundAWE is a rare form of endometriosis that often results in cyclic abdominal pain. The current treatment algorithm for AWE is not well established. Microwave ablation technology is a promising new thermal ablation technique for treating AWE.MethodsThis was a retrospective study of nine women with pathologically proven endometriosis of the abdominal wall. All patients were treated with ultrasound-guided microwave ablation. Grey-scale and color Doppler flow ultrasonography, contrast-enhanced ultrasonography, and MRI were used to observe the lesions before and after treatment. The complications, pain relief, AWE lesion volume, and volume reduction rate were recorded 12 months after treatment to evaluate the treatment efficacy. Complications were classified according to the Common Terminology Criteria for Adverse Events and the Society of Interventional Radiology classification system.ResultsContrast-enhanced ultrasound showed that all lesions underwent successful treatment with microwave ablation. The average initial nodule volume was 7.11 ± 5.75 cm3, which decreased significantly to 1.85 ± 1.02 cm3 at the 12-month follow-up with a mean volume reduction rate of 68.77 ± 12.50%. Periodic abdominal incision pain disappeared at 1 month after treatment in all nine patients. The adverse events and complications were Common Terminology Criteria for Adverse Events grade 1 or Society of Interventional Radiology classification grade A.ConclusionsUltrasound-guided microwave ablation is a safe and effective technique for the treatment of AWE, and further study is warranted.
Correlation analysis between renal anatomical factors and residual stones after an ultrasound-guided PCNL
Authors: Zhu Shusheng , Fan Yanpeng , Hu Xia , Shao Mingming 
Published: April 2023

IntroductionTo predict the factors of residual stones after percutaneous nephrolithotomy (PCNL) by analyzing the characteristics of the renal anatomical structure in intravenous urography, so as to make a reasonable operation plan, reduce the risk of residual stones in PCNL, and improve the stone-free rate (SFR).MethodsA retrospective study was performed between January 2019 and September 2020 for patients treated with PCNL. According to the results of a kidney ureter bladder review after PCNL, 245 patients were divided into a residual stone group (71 patients, stone size &gt;4 mm) and a stone-free group (174 patients, stone size ≤4 mm). An independent sample t-test was used to analyze the age, the length and width of channel calices, the angle between the channel calices and the involved calices, and the length and width of the involved calices. The gender, the channel types, the number of channels, the degree of hydronephrosis, and the number of involved calices were analyzed by using the chi-square test. A score of p &lt; 0.05 was considered statistically significant. At the same time, logistic regression analysis was carried out to explore the independent influencing factors of the SFR after PCNL.ResultsA total of 71 patients developed residual stones after surgery. The overall residual rate was 29.0%. The width of the channel calices (p = 0.003), the angle between the channel calices and the involved calices (p = 0.007), the width of the involved calices (p &lt; 0.001), the channel types (p = 0.008), and the number of involved calices (p &lt; 0.001) were all significantly correlated with residual stones after PCNL. Logistic regression analysis showed that the width of the channel calices (p = 0.003), the angle between the channel calices and the involved calices (p = 0.012), the width of the involved calices (p &lt; 0.001), the channel types (p = 0.008), and the number of involved calyces (p &lt; 0.001) were all independent influencing factors of the SFR after PCNL.ConclusionA larger caliceal neck width and angle can reduce the risk of residual stones. The more calyces that are involved, the higher the risk of residual stones. There was no difference between F16 and F18, but F16 had a higher SFR than F24.
Risk factors associated with tendon adhesions after hand tendon repair
Authors: Jia Qiyu , Chen Dongsheng , Guo Jian , Luo Xuefeng , Alimujiang Abudusalamu , Zhang Jun , Hu Ningning , Liu Yanshi , Xie Zengru , Ma Chuang 
Published: April 2023

BackgroundTendon adhesions after hand tendon repair are one of the most difficult complications of hand surgery and can cause severe disability. This study aimed to assess the risk factors associated with tendon adhesions after hand tendon repair to provide a theoretical foundation for the early prevention of tendon adhesions in patients with tendon injuries. Moreover, this study intends to increase doctors' awareness of the issue and serves as a reference for developing new prevention and treatment strategies.MethodsWe retrospectively analyzed 1,031 hand trauma cases that underwent repair after finger tendon injury in our department between June 2009 and June 2019. Tendon adhesions, tendon injury zones, and other relevant information were collected, summarized, and analyzed. The significance of data was determined using a t-test or Pearson's chi-square test, and odds ratios (OR) were calculated using logistic regression tests to describe factors associated with post-tendon repair adhesions.ResultsA total of 1,031 patients were enrolled in this study. There were 817 males and 214 females with an average age of 34.98 (2–82) years. The injured side included 530 left and 501 right hands. Postoperative finger tendon adhesions occurred in 118 cases (11.45%), including 98 males and 20 females, 57 left and 61 right hands. The risk factors for the total sample in the descending order were degloving injury, no functional exercise, zone II flexor tendon injury, time from injury to surgery &gt;12 h, combined vascular injury, and multiple tendon injuries. The flexor tendon sample shared the same risk factors as the total sample. Risk factors for the extensor tendon sample were degloving injury, no functional exercise.ConclusionsClinicians should pay close attention to patients with tendon trauma in hand having the following risk factors: degloving injury, zone II flexor tendon injury, lack of functional exercise, time from injury to surgery &gt;12 h, combined vascular injury, and multiple tendon injuries. Due to the high risk of post-repair adhesions in patients with the conditions mentioned above, individualized treatment measures should be designed for the risk factors, and postoperative functional exercise of the hand is required.
Ectomycorrhizal Community Shifts at a Former Uranium Mining Site
Authors: Bogdanova Olga , Kothe Erika , Krause Katrin 
Published: April 2023

Ectomycorrhizal communities at young oak, pine, and birch stands in a former uranium mining site showed a low diversity of morphotypes with a preference for contact and short-distance exploration strategies formed by the fungi Russulaceae, Inocybaceae, Cortinariaceae, Thelephoraceae, Rhizopogonaceae, Tricholomataceae, as well as abundant Meliniomyces bicolor. In order to have better control over abiotic conditions, we established pot experiments with re-potted trees taken from the sites of direct investigation. This more standardized cultivation resulted in a lower diversity and decreased prominence of M. bicolor. In addition, the exploration strategies shifted to include long-distance exploration types. To mimic secondary succession with a high prevalence of fungal propagules present in the soil, inoculation of re-potted trees observed under standardized conditions for two years was used. The super-inoculation increased the effect of lower abundance and diversity of morphotypes. The contact morphotypes correlated with high Al, Cu, Fe, Sr, and U soil contents, the dark-colored short-distance exploration type did not show a specific preference for soil characteristics, and the medium fringe type with rhizomorphs on oaks correlated with total nitrogen. Thus, we could demonstrate that field trees, in a species-dependent manner, selected for ectomycorrhizal fungi with exploration types are likely to improve the plant’s tolerance to specific abiotic conditions.
Influence of Season and Habitat on the Essential Oils Composition, Allelopathy, and Antioxidant Activities of Artemisia monosperma Delile
Authors: Abd-ElGawad Ahmed M. , Assaeed Abdulaziz M. , Al-Rowaily Saud L. , Alshahri Mohamed S. , Bonanomi Giuliano , Elshamy Abdelsamed I. 
Published: April 2023

Plants belonging to the Artemisia genus (Asteraceae) are widely distributed worldwide and have many ethnopharmacological, traditional, therapeutic, and phytochemical aspects. Artemisia monosperma is an important aromatic plant due to its traditional and therapeutic uses and phytochemical diversity, including essential oils (EOs). The EO chemical profile of aromatic plants has been reported to be affected by exogenous and endogenous factors. Geographic and seasonal variations are crucial factors shaping the chemical composition of the EO. Herein, the variations of the yields, chemical profiles, and allelopathic and antioxidant activities of A. monosperma EOs collected from three regions in four seasons were assessed. A slight variation in the oil yields was observed among regions and seasons, while the chemical profile, characterized via GC-MS, exhibited significant quantitative and qualitative variation among either regions or seasons. Sesquiterpenes were the main components of all EOs, with significant variation in concentration. In most EO samples, the summer-plant samples had the highest concentration of sesquiterpenes, followed by spring, winter, and autumn. The 7-epi-trans-sesquisabinene hydrate, 6-epi-shyobunol, dehydro-cyclolongifolene oxide, isoshyobunone, diepicedrene-1-oxide, dehydro-aromadendrene, and junipene were the main compounds of all the EO samples. The extracted EOs of the A. monosperma samples showed considerable allelopathic activity against the weed Dactyloctenium aegyptium and the crop Lactuca sativa. A significant variation in allelopathic activity was observed among samples collected during different seasons, while the samples of the autumn and summer seasons had more potential. Also, L. sativa was more affected by the EO compared to D. aegyptium, reflecting that weeds are more resistant to allelochemicals. In this context, the EOs of A. monosperma samples exhibited substantial antioxidant activity with the same pattern of allelopathic activity, whereas the samples of the autumn and summer seasons showed higher antioxidant activity. These biological activities of the EOs could be ascribed to the higher content of oxygenated compounds. The present study revealed that seasons have a substantial effect on EO production as well as composition. In consequence, the biological activities varied with the variation of the chemical profile of the EO. These results show the importance of season/timing for sampling aromatic plants.
Peran Undang-Undang Ketenagakerjaan Dalam Perlindungan Permasalahan Pemutusan Hubungan Kerja Yang Menjadikan Jumlah Pengangguran Meningkat
Authors: Gitamo Zhafira , Santoso Imam Budi 
Published: April 2023

Hukum ketenagakerjaan mengatur hubungan antara para pengusaha dengan para tenaga kerja, para pengusaha dengan para pengusaha, dan para tenaga kerja dengan para tenaga kerja dilakukan pada aktu sebelum bekerja, saat bekerja, hingga sesudah bekerja dengan tujuan meningkatkan kesejahteraan bagi para pekerjanya. Penelitian ini merupakan penelitian gabungan antara studi normatif dan empiris. Studi empiris dalam penelitian bukan untuk mencari data-data primer, melainkan data-data yang diperoleh data-data sekunder dari berbagai sumber baik media cetak maupun online. Adapun kasus-kasus dan pendapat pakar yang ada dalam penelitian ini diperoleh dari berbagai penelitian sebelumnya yang berkaitan dengan perlindungan hukum bagi para buruh/pekerja yang mengalami Pemutusan Hubungan Kerja. Tingkat Pengangguran Terbuka pada periode Februari 2021 sebesar 8,92%, naik menjadi sebesar 1,21% dibandingkan dengan keadaan dengan Februari 2020. Dikarenakan Pemutusan Hubungan Kerja dan belum meratanya kesempatan kerja bagi seluruh warga Karawang. Kemudian Bupati Karawang menerbitkan Perda No 1 Tahun 2011 di Kab Karawang memberikan perlindungan kepada warga asli Kabupaten Karawang yang belum mendapatkan pekerjaan atau kesempatan untuk bekerja.