bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of virtual reality for psychological health of ICU patients: a study protocol for systematic review and meta-analysis
Authors: Zou Junjun , Chen Qian , Wang Jiajia , Gu Mengqian , Jiang Xiaoquan , Mao Mingyue 
Published: July 2023

IntroductionVirtual reality (VR) has been shown to have a certain influence on the psychological health of intensive care unit (ICU) patients. However, its specific effects—particularly on psychological health problems, such as psychological well-being, quality of life (QOL) and patient satisfaction—remain unclear.Method and analysisThis study follows the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols guidelines. Electronic data search is carried out on PubMed, Web of Science, CINAHL, EBSCO, EMBASE, Cochrane Library, PsycINFO, China National Knowledge Infrastructure, Wan Fang, VIP and Chinese Biology Medicine Database. The inclusion criteria follow the PICO principle, wherein ICU patients who have been hospitalised for 24 hours or more are included. Studies using VR-based interventions to improve the psychological health of ICU patients, compared with waitlist controls or traditional therapy groups; outcome assessments containing psychological well-being, QOL and patient satisfaction; and those designed as randomised controlled trials (RCTs) and quasi-experimental research are included. Search time is from inception of each database to July 2023. No language restriction is considered. Studies for inclusion are screened by two independent reviewers for data extraction. Any dispute is resolved through discussion. Unresolved disputes are decided on by consulting a third author. For the risk of bias assessment in RCTs and non-RCTs, the Cochrane risk-of-bias tool for randomised trials and risk of bias in non-randomised studies of interventions tool are used, respectively. For meta-analysis, RevMan V.5.3 is used.Ethics and disseminationThis protocol study does not include clinical research and thus does not require ethical approval. Research findings will be released in a peer-reviewed journal.PROSPERO registration numberCRD42023400428.
Developing an in-depth understanding of patient and caregiver engagement across care transitions from hospital: protocol for a qualitative study exploring experiences in Canada
Authors: Elliott Jacobi , van Wyk Paula , Butler Roy , Giosa Justine L , Sims Gould Joanie , Tong Catherine E , Taabazuing Mary Margaret , Johnson Helen , Coyne Paige , Mitchell Fallon , Whate Alexandra , Callon Anne , Carson Judith , Stolee Paul 
Published: July 2023

IntroductionPatient and caregiver engagement is critical, and often compromised, at points of transition between care settings, which are more common, and more challenging, for patients with complex medical problems. The consequences of poor care transitions are well-documented, both for patients and caregivers, and for the healthcare system. With an ageing population, there is greater need to focus on care transition experiences of older adults, who are often more medically complex, and more likely to require care from multiple providers across settings. The overall goal of this study is to understand what factors facilitate or hinder patient and caregiver engagement through transitions in care, and how these current engagement practices align with a previously developed engagement framework (CHOICE Framework). This study also aims to co-develop resources needed to support engagement and identify how these resources and materials should be implemented in practice.Methods and analysisThis study uses ethnographic approaches to explore the dynamics of patient and caregiver engagement, or lack thereof, during care transitions across three regions within Ontario. With the help of a front-line champion, patients (n=18–24), caregivers (n=18–24) and healthcare providers (n=36–54) are recruited from an acute care hospital unit (or similar) and followed through their care journey. Data are collected using in-depth semi-structured interviews. Workshops will be held to co-develop strategies and a plan for future implementation of resources and materials. Analysis of the data will use inductive and deductive coding techniques.Ethics and disseminationEthics clearance was obtained through the Western University Research Ethics Board, University of Windsor Research Ethics Board and the University of Waterloo Office of Research Ethics. The findings from this study are intended to contribute valuable evidence to further bridge the knowledge to practice gap in patient and caregiver engagement through care transitions. Findings will be disseminated through publications, conference presentations and reports.
A Global Perspective on the Upper Branch of the Hadley Cell
Authors: Hoskins B. J. , Yang G.-Y. 
Published: July 2023

Abstract
The global perspective presented here is built on earlier papers discussing the dynamics of the upper branch of the Hadley cell in the two solsticial seasons. The role of the tropics is made explicit in a conceptual model that is presented and evaluated. The fluctuation of deep tropical convection in longitude and time is seen as crucial. The filamentary outflows from such convective events move westward and across the equator deep into the winter hemisphere. The horizontal tilt of the cross-equatorial flow implies a significant upper-tropospheric flux of westerly momentum from the winter tropics to the summer hemisphere. These properties are related to the cross-equatorial propagation of wave activity triggered by deep tropical convection in the summer hemisphere. The filaments carry with them near-equatorial values of absolute vorticity and potential vorticity. After turning anticyclonically, some filaments move eastward and poleward to the equatorial edge of the winter subtropical jet. There is strong evidence they can interact with the eddies on this jet and enhance their poleward westerly momentum flux. In the global perspective, tropical and extratropical systems and the interaction between them are all important for the dynamics of the upper branch of the Hadley cell.

significance statement
The Hadley cell is the large-scale overturning in the atmosphere with air in the upper troposphere moving from the equatorial region to near 30° in the winter hemisphere. In the standard view it is midlatitude weather systems that are responsible for removing angular momentum from this upper branch of the Hadley cell. Here it is proposed that tropical systems and their interaction with the midlatitude systems are also important. Insight into the role of the tropics in the dynamics of the Hadley cell can be obtained by considering it as the sum of many events of active deep convection occurring in different longitudes and at different times.
Delayed presentation of vincristine extravasation
Authors: Ghaffary Saba , Gholami Nasrin , Samankan Sama , Pourkarim Fariba 
Published: July 2023

Introduction Vincristine is a vesicant chemotherapeutic agent which may leak from the vessel at the infusion site to the perivascular tissue and cause extravasation. Extravasation, a severe complication of chemotherapeutic drugs, can result in tissue necrosis that is considered an oncological emergency. Case report We aimed to report a case of a 29-year-old woman with ALL-B cell (Acute lymphoblastic leukemia) on maintenance chemotherapy regimen including vincristine, methotrexate, prednisolone, and 6-mercaptopurine (POMP). 48 h after administering intravenous vincristine, the patient experienced burning, pain and tenderness at the injection site (left hand – cubital cavity). Management & outcome 7 days after the onset of symptoms, the patient was hospitalized with a large brown lesion at the site. She was prescribed betamethasone cream, DSMO (Dimethyl sulfoxide) solution, and oral levofloxacin on his second day after admission. The lesion was completely improved 10 days after initiation of therapy and there were no serious problems. Discussion Due to the ineffectiveness of antidote therapy for the management of delayed extravasation of vincristine and beneficial effect of our clinical approach, it could consider for the management of similar cases with delayed extravasation following vincristine administration.
Management of post-traumatic stress disorder symptoms by yoga: an overview
Authors: Laplaud Nina , Perrochon Anaïck , Gallou-Guyot Matthieu , Moens Maarten , Goudman Lisa , David Romain , Rigoard Philippe , Billot Maxime 
Published: July 2023

Abstract
Background
Posttraumatic stress disorder (PTSD) can occur after trauma. While PTSD management strategies include first-line pharmacotherapy and psychotherapy, mind–body therapies, such as yoga, are applied in the PTSD population. This overview aimed to summarize the effectiveness of yoga interventions on PTSD symptoms in adults in a systematic review (SR) including randomized controlled trials (RCTs).

Method
We searched for SR with or without meta-analysis of RCTs involving adults with PTSD diagnosis or trauma history. The search was conducted until April 2022, through six databases (Cochrane Database, MEDLINE (Pubmed), Scopus, Embase, CINHAL and PEDro). The primary outcome was the evolution of PTSD symptoms throughout the intervention. Secondary outcomes included follow-up, safety, adherence, and cost of the intervention. Two authors independently performed the selection, data extraction and risk of bias assessment with the AMSTAR 2 tool and overlap calculation. This overview is a qualitative summary of the results obtained in the selected studies.

Results
Eleven SRs were analyzed, of which 8 included meta-analyses. The overlap between studies was considered very high (corrected covered area of 21%). Fifty-nine RCTs involving 4434 participants were included. Yoga had a significant small-to-moderate effect-size on PTSD symptom decrease in 7 SRs and non-significant effects in 1 SR with meta-analysis. All SR without meta-analysis found beneficial effects of yoga on PTSD. Secondary outcomes were not sufficiently assessed to provide clear evidence. Results should be interpreted with caution as 1 SR was rated as at moderate risk of bias, 3 as low and 7 as critically low.

Conclusions
While yoga therapy seems promising for decreasing PTSD symptoms, future research should standardize yoga therapy duration/frequency/type and consider long-term efficacy to better delineate yoga therapy efficacy in PTSD patients.
Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Authors: Wang Huifang , Zhou Runhua , Xu Fushan , Yang Kongjun , Zheng Liuhai , Zhao Pan , Shi Guangwei , Dai Lingyun , Xu Chengchao , Yu Le , Li Zhijie , Wang Jianhong , Wang Jigang 
Published: July 2023

Abstract
Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery of cellular degradation pathways, including but not limited to proteasomes and lysosome pathways as well as their degraders, is an area of active research. Since the concept of proteolysis-targeting chimeras (PROTACs) was introduced in 2001, the paradigm of TPD has been greatly expanded and moved from academia to industry for clinical translation, with small-molecule TPD being particularly represented. As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusion protein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significant advancement in recent years, demonstrating unique and promising activities beyond those of conventional small-molecule TPD. In this review, we provide an overview of recent advances in bioTPD technologies, summarize their compositional features and potential applications, and briefly discuss their drawbacks. Moreover, we present some strategies to improve the delivery efficacy of bioTPD, addressing their challenges in further clinical development.
Prolonged RT-PCR test positivity in hemodialysis patients with COVID-19
Authors: Alfano Gaetano , Morisi Niccolò , Ferri Camilla , Fontana Francesco , Giovanella Silvia , Ligabue Giulia , Mori Giacomo , Franceschini Erica , Ferrari Annachiara , Gregorini Mariacristina , Cappelli Gianni , Tagliazucchi Sara , Pecorari Monica , Guaraldi Giovanni , Magistroni Riccardo , Donati Gabriele 
Published: July 2023

Abstract
Background
The weakened immune system of patients on hemodialysis (HD) may prolong SARS-CoV-2 infection compared to the general population. Current international guidelines recommend ending isolation in conjunction with serial testing in moderately and severely immunocompromised subjects. This study aimed to estimate SARS-CoV-2 infectivity by measuring RT-PCR test positivity in HD patients. A comparison between RT-PCR test and cycle threshold (Ct) value has been performed as a secondary endpoint.

Methods
A single-center retrospective study was conducted at the University of Modena (Italy) from March 2020 to October 2022. Only patients on chronic HD therapy with COVID-19 were enrolled in the study. In our HD Center, two negative nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) results were used to end quarantine in this population. SARS-CoV-2 RT-PCR test positivity duration measured the time elapsed from a positive RT-PCR to a second negative test. Ct cut-off of 35 cycles was used to definite “high Ct value,” a condition characterized by a large number of cycles of PCR amplification to register a positive RT-PCR test.

Results
During the observational period, 159 cases of SARS-CoV-2 infections were diagnosed in 151 patients. Median age was 70.1 (54.3–81.6) years and males accounted for 59.6% of the COVID-19 population. Median duration of SARS-CoV-2 RT-PCR test positivity on the nasal mucosa accounted for 30 (IQR, 21–40.5) days. Unvaccinated patients experienced significantly longer RT-PCR test positivity compared to vaccinated patients (42 [IQR,31–56] vs. 28 [IQR,20–35.7] days; p =  < 0.001). The use of high Ct value, a laboratory surrogate of SARS-CoV-2 replication, anticipated a negative RT-PCR test of 9 (IQR, 6–12) days. Multivariate linear regression analysis showed that increased age (β coefficient 0.31; confidence interval [CI] 95%, 0.14—0.43; p =  < 0.001) and the lack of anti-SARS-CoV-2 vaccination (β 0.49 CI95%, 11.9–22.5; p =  < 0.001) were predictors of a prolonged RT-PCR positivity.

Conclusions
Patients with COVID-19 on HD had prolonged RT-PCR test positivity. The adoption of “high Ct value” criteria led to a significant reduction in the duration of RT-PCR test positivity compared to the use of the classical nucleic acid amplification test. In our study, the lack of SARS-CoV-2 vaccination and older age were independently associated with a longer RT-PCR positivity.
Group combined failure in tension of extended hollo blind bolts using numerical finite element method
Authors: Guo Yongchang 
Published: July 2023

Abstract
The structural hollow sections (SHS) have several advantages comparing with the open sections. However, the application of the SHS in the industry is limited due to the traditional bolt connection and cannot be used for the SHS as the inaccessibility to the inside of section. Several blind bolt systems were developed to overcome this problem and the EHB is the modified version of one of the blind bolt systems.This project aims to investigate the behaviour of the Extended Hollo-bolt (EHB) connection under combined failure mode with a focus on the influence of the bolt pitch distance by using test data and Finite Element (FE) models and to propose an analytical model for the connection. The EHB connection is between a SHS column filled with concrete and a beam made of an open section. Two rows of EHB were embedded in concrete filled SHS and tested under tension.FE models were created and validated by tests data and they were used to investigate the aforementioned aims. It is found that pitch distance has a significant influence on the strength of the connection as increase of the pitch distance increases the strength of the connection until a critical value. An analytical model was also proposed for the connection.
Attitudes and habits regarding brain training applications and games among Japanese consumers: a preliminary cross-sectional study
Authors: Robb Nigel 
Published: July 2023

Background: While there is now a large amount of research investigating whether brain training applications and games are effective or not, there is less research on the expectations, attitudes, and habits of potential users of brain training programs. Previous research suggests that people generally have positive beliefs about the effectiveness of brain training which are not dependent on their level of experience of brain training. However, this research has primarily focused on western participants. Methods: In the present study, a questionnaire was used to investigate the attitudes and habits of Japanese consumers towards brain training. The final sample contained responses from 818 people. In addition to descriptive statistics, correlation coefficients were calculated to determine if there were relationships between variables relating to participants' beliefs about brain training and experience of using brain training. Results: Participants had positive beliefs about the effectiveness of brain training. However, these beliefs were negligibly or weakly correlated with their level of experience of using brain training, both in terms of the number programs used (Pearson's r = 0.163) and duration of use (Pearson's r = 0.237). The most widely used brain training program (used by 52.93% of participants) was made by Nintendo for the handheld Nintendo DS games console. Conclusions: The research presented here supports previous findings which suggest that people's beliefs about the effectiveness of brain training software are not strongly related to their experience of using such software.
Soziale Theologie des Kindes
Authors: Sedmak Clemens 
Published: July 2023

Zusammenfassung
Der Artikel skizziert die Idee der Vorstellungskraft wie auch der theologischen Vorstellungskraft, die für eine Theologie des Kindes eine entscheidende Rolle spielt. In kirchlichen Texten, etwa der Katholischen Soziallehre, ist die Vorstellungskraft mitunter eng geführt, was zu einem dürren Verständnis von Kindern und Kindsein führt. Die theologische Vorstellungskraft kann von Erfahrungshorizonten wie auch von biblischen Texten vertieft und ausgeweitet werden. Dabei spielt die ›Diät an Beispielen‹ eine wichtige Rolle, was anhand Ian Browns Beschreibung seines schwer behinderten Sohnes und anhand der biblischen Geschichte der Tochter des Jiftach illustriert wird. Abschließend wird die Vorstellungskraft bemüht, um den Gedanken der fundamentalen Gleichheit zwischen Erwachsenen und Kindern auszudrücken und die Diskurse und Praktiken in Bezug auf Kinder zu dekolonialisieren.
Short- and long-term outcomes of patients with COVID-19 and acute kidney injury
Authors: Khruleva Yu. V. , Efremovtseva M. A. , Timofeeva Yu. A. , Vatsik-Gorodetskaya M. V. , Kobalava Zh. D. 
Published: July 2023

Aim. To evaluate the impact of acute kidney injury (AKI) on in-hospital (death) and long-term outcomes (rehospitalization or death within 30 days; death within 180 days) in hospitalized patients with coronavirus disease 2019 (COVID-19).Material and methods. The registry of patients with COVID-19 was analyzed to identify risk factors (RFs) for mortality. Discharged patients were included in a prospective study. Outcomes were assessed by telephone contacts.Results. The study included 1000 patients. The mortality rate was 20,8%, while AKI was registered in 29,6% of patients. According to multi­variate analysis, AKI, regardless of other risk factors, increased the risk of death (hazard ratio (HR), 1,62, 95% confidence interval (CI): 1,08-2,44, p=0,02). The prospective part included 691 patients. We revealed that 10% were rehospitalized or died within 30 days, while independent risk factors were age >65 years (HR, 2,72, 95% CI: 1,47-5,01, p=0,001) and AKI in the acute phase of COVID-19 (HR, 1,67, 95% CI: 1,00-2,80, p=0,05). In addition, 6% of patients died within 180 days, while AKI was the risk factor for death according to univariate analysis; the only independent predictor was age >65 years (HR, 5,96, 95% CI: 2,26-15,72, p<0,001).Conclusion. AKI during the acute period of COVID-19, independently of other risk factors, more than 1,5 times increases the risk of mortality and the risk of adverse outcome within 30 days after discharge.
Formation stages of the Kholodninskoye pyrite-polymetallic deposit ore zone
Authors: Tarasova Yu. I. , Budyak A. E. 
Published: July 2023

The Kholodninskoe pyrite-polymetallic deposit (Baikal-Patom plateau, Russia) was discovered in 1968, but the questions of its genesis still remain controversial. It is assumed that the explosive activity of volcanic apparatuses of the southern part of the Baikal-Muya zone as well as underwater exhalations of the scattered spreading zone of the back-arc basin could have most likely influenced the geochemical features of amagmatic deposits of the Bodaibo and Patom zones. To investigate the influence of underwater hydrothermal activity on the geochemical features of Neoproterozoic carbonbearing sediments of the Baikal Mountain region, the Olokit zone, which is a fragment of the spreading zone of the backarc basin, was chosen. According to the geochemical parameters, the sediments of the Itykit and Ondokskaya formations hosting the Kholodninskoye deposit fall into the sedimentation area of DalnyaTaiga period paleobasins. Having compared the development of sulfide mineralization of ore objects of the Bodaibo and Olokit structural-formation zones, the authors suggest the unity of deposit formation processes within the Baikal Mountain area. The presence of framboidal pyrite indicates that the early stages of ore formation of the Kholodninskoe hydrothermal-stratiform polymetallic deposit were synchronous with sedimentation. The source of deposit ore zone enrichment with zinc lead, silver and other elements typical for low- and medium-temperature associations was a hydrothermal solution of the scattered spreading zone of back-arc basins. It is likely that the explosive and exhalation activities of the southern Baikal-Muya zone within the studied region also spread further northward, thus influencing the formation of siderochalcophilic geochemical specialization of amagmatic black shale strata of the Bodaibo and Patom zones.
Consensus on the diagnosis and treatment of PROS (PIK3CA-related overgrowth spectrum). Russian version
Authors: Sagoyan G. B. , Zhukov N. V. , Strelnikov V. V. , Khagurov R. A. , Suleymanova A. M. , Mareeva Yu. M. , Garbuzov R. V. , Imyanitov E. N. , Dinikina Yu. V. , Kutsev S. I. , Donyush E. K. , Kirgizov K. I. , Semenova N. A. , Polyaev Yu. A. , Kletskaya I. S. , Maschan A. A. , Varfolomeeva S. R. 
Published: July 2023

PROS (PIK3CA-Related Overgrowth Spectrum) encompasses vascular malformations, lipomatosis and other multiple congenital anomalies resulting from activating somatic mutations in the PIK3CA gene. PROS includes macrodactyly, hemimegalencephaly, muscle hemihypertrophy, facial infiltrating lipomatosis CLOVES, megalencephaly, vascular malformations (capillary, venous, lymphatic, arteriovenous and combined vascular malformations), skin disorders, epidermal nevi, etc.The experts of the Russian Society of Pediatric Oncologists and Hematologists, Russian Association of Pediatric Surgeons and Russian Society of Medical Geneticists developed this consensus statement of diagnostics and treatment of PROS.