bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraperitoneal versus Intravenous Dexamethasone Effect on Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Authors: Ali Mohamed A , Abd El Latef Ayman A , Soliman Samar M , Anis Marco S 
Published: August 2023

Abstract

Background
Post-operative nausea and vomiting (PONV) is a common unwanted effect in patients undergoing laparoscopic cholecystectomy (LC). This study compared the effect of intraperitoneal versus intravenous dexamethasone for reducing PONV after laparoscopic cholecystectomy surgeries.

Aim of the Work
to compare the efficacy of intraperitoneal versus intravenous administration of dexamethasone in reducing the incidence of PONV after LC surgeries.

Patients and Methods
Ninety patients, American Society of Anesthesiologists physical status I–II, scheduled for laparoscopic cholecystectomy surgery were randomized to receive 8 mg dexamethasone intraperitoneally (IP) (n = 45) or intravenously (IV) (n = 45). The primary outcome was the PONV incidence during the first 24 h after laparoscopy. Secondary outcomes included visual analogue scale (VAS) pain scores, total analgesic consumption during the first 24 h postoperatively, the need for rescue antiemetic drugs, and the incidence of complications that may accompany these medications.

Results
The incidence of nausea in the IV group was 26.7% (12 patients) and that in the IP group was 6.7% (3 patients) in the first 24 hours post-operatively (P = 0.011). There were no significant differences in the incidence of retching or vomiting, or the need for rescue antiemetics between the 2 groups. In terms of side effects, patients in the IP group had a lower rate of side effects than those in the IV group (6.7% vs. 24.4%, P = 0.020). The mean VAS pain score and total pethidine consumption for the first 24 hours postoperatively were lower in the IP group than in the IV group. However, these differences did not reach statistical significance.

Conclusion
Intraperitoneal injection of dexamethasone at a dose of 8 mg in patients undergoing Laparoscopic Cholecystectomy surgery reduces significantly the incidence of postoperative nausea, in comparison to the intravenous route.
Value of Transthoracic Echocardiography in Predicting Short Term Major Adverse Cardiac Events after ST Elevation Myocardial Infarction in COVID 19 Era
Authors: Farouk Dina , Bastawy Islam , Rayan Mona 
Published: August 2023

Abstract

Background
Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide. In the era of COVID 19, early risk stratification and identification of high-risk patients with ST-segment elevation myocardial infarction are of great significance in prognosis, and in guiding diagnosis and treatment decisions. Measuring left ventricular peak systolic global longitudinal strain may be a useful addition to ejection fraction using echocardiography.

Aim of the Study
Is to evaluate different parameters of echocardiography in predicting major adverse cardiac events in patients after acute ST-segment elevation myocardial infarction in the era of Covid 19.

Methods and patients
This study included 97 patients who presented with acute STsegment elevation myocardial infarction within 12 hours of onset of chest pain and managed by primary percutaneous coronary intervention, it was performed in Ain Shams university hospitals from January 2021 to June 2021. Echocardiography was used to measure ejection fraction and left ventricular strain parameters

Results
The study included 97 patients, 55 % of which presented with anterior STEMI. Out of the whole group 29 patients (21%) developed MACE at 3 months follow up. Within the whole group, the mean ejection fraction was (44.04±6.07% VS .40.07±6.52% p = 0.007) and the mean global longitudinal strain was (-12.56±3.61% VS -10.1±3.25% p=0.002). Based on CT chest finding, 33 patients were Covid 19 patients who were younger in age, included significantly more females and had significantly higher Killip score as compared to the non covid patients. Among COVID-19 patients, the mean ejection fraction was (46.11±5.29% VS 40.6±7.11% p=0.02) and the mean global longitudinal strain was (-13.17±3.35% VS 10.35±3.38% p=0.026). At 3 months follow up, 39% of the Covid patients had MACE as compared to 25% of the non covid patients P = 0.0001.

Conclusion
In the era of COVID 19, young patients with female gender who suffered from STEMI were more likely to be COVID 19 patients and were liable to develop MACE at 3 months follow up. However, their LV EF and GLS were comparable to non-COVID 19 patients

Ethical approval
this study protocol was approved by the local ethics committee with a consent was obtained from all participants.

Abbreviations
MACE: major adverse cardiac events; LV: left ventricle; GLS: global longitudinal strain; STEMI: ST elevation myocardial infarction
Ambulatory Blood Pressure Monitoring in Assessment of Systemic Hypertension Following Successful Aortic Coarctation Repair
Authors: Mahmoud Sameh Ali , Alimam Ahmed Mowad , Esmail Yasmin Abdelrazek , Attia Hebatalla Mohamed , Hamdy ElSayed Maiy 
Published: August 2023

Abstract

Background
Hypertension following primary coarctation repair affects up to a third of subjects. A number of studies suggest that future hypertension risk is reduced if primary repair is performed at a younger age. This study aims to assess prevalence of systemic hypertension after early coarctation repair (within the first two years of life) compared with late coarctation repair (after the first two years of life), including both catheter-based and surgical intervention using twenty-four hour ambulatory blood pressure monitoring. the study included 30 patients who underwent successful repair of aortic coarctation. All patients underwent complete history taking and clinical examination.All patients underwent full transthoracic echocardiographic study and ambulatory blood pressure monitoring.

Results
HTN had higher incidence in patients who underwent late coarctation repair than patients underwent early coarctation repair but difference was statistically insignificant.

Conclusions
Early intervention of aortic coarctation during infancy decreases the risk of late systemic hypertension. However, further studies are needed to evaluate increased risk of recoarctation after early intervention of aortic coarctation.
Diagnostic Efficacy of Carba NP Strip Test for Carbapenemase Detection
Authors: El-masry Shereen Ahmed , Fahim NohaAlaaEldin , Badawy Lamya Ahmed ElnasserElsayed 
Published: August 2023

Abstract

Background
Bacterial resistance to carbapenems is in the focus of attention because it envoys a time without effective antibiotics. Carbapenemase enzyme production is the main mechanism of resistance exhibited by carbapenem resistant organisms. Rapid detection of carbapenemase producing bacteria is important for initiation of treatment and infection control measures.

Aim of the Work
Determination of the diagnostic performance of the Carba NP strip test for the detection of carabapenemase producing gram negative bacteria.

Materials and Methods
The study included a total of 50 gram negative clinical isolates. All isolates were subjected to: Carba NP tube test, Carba NP strip test, and meropenem disc diffusion. All techniques were performed according to Clinical and laboratory standard institute (2018).

Results
Compared to the results of the meropenem (10 ug) disc diffusion method, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the Carba NP tube test was found to be 77.5%, 100%, 100% and 52.6 % respectively. On the other hand, the Carba NP strips test was found to have 82.5% sensitivity, 100% specificity, 100% PPV and 58.8% NPV.

Conclusion
The Carba NP test performed by use of the modified strip method was found to be a simple and inexpensive method that can be used for the rapid detection of carbapenemase producing gram negative bacteria with high sensitivity and specificity.
Effect of Narrow Band UVB Therapy and Methotrexate Treatment on Serum Adenosine Deaminase Enzyme Level in Severe Psoriasis Vulgaris Patients
Authors: Mabrouk Delbent Ibrahim , Elhusseiny Rania Mahmoud , Abdullah Hala Jabbar Hussein 
Published: August 2023

Abstract

Background
Psoriasis is a common, chronic inflammatory disease effects mainly skin, nails and joints. Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and it is essential for the breakdown of adenosine from food and the turnover of nucleic acids in tissue. ADA possess a pivotal role in function and maturation of lymphoid cells, especially T-cell lineage, and its altered status was reported in diseases with immunological disturbances as in psoriasis. Moreover, ADA regulates the plasma adenosine level, which is involved in synthesis of inflammatory molecules and cytokine production. Increased ADA may be also due to increased nucleic acid catabolism associated with the hyperproliferative status of epidermis in psoriasis patients.

Aim of the Study
To measure serum level of adenosine deaminase enzyme by modified Guisti procedures in severe psoriasis vulgaris patients before and after treatment with narrow band ultraviolet B therapy and intramuscular methotrexate injection or combination of both and compare it with healthy controls.

Subjects and Methods
The present study included 45 severe psoriasis vulgaris patients and 15 apparent healthy age and sex matched controls. The study was approved by the Research Ethical Committee, Faculty of Medicine, Ain Shams University and fulfilled all the ethical aspects required in human research. All patients received full information about description of the procedure of treatment, possible side effects, photo documentation and they all provided informed consent.

Results
The current study revealed significant decrease in disease severity after treatment in all 3 groups with decreased PASI score. Serum ADA was significantly higher in patients groups compared to controls. Moreover, significant reduction of serum ADA was detected after treatment in all three groups being higher in combined MTX and NBUVB group. However, no significant correlation was detected between serum ADA levels and PASI scores before and after treatment.

Conclusion
We concluded that Adenosine deaminase possesses a significant role in the pathogenesis of psoriasis. Measurement of serum ADA level could be used as both diagnostic and prognostic marker for psoriasis and monitoring progress of treatment.
Assessment of YKL-40 as a Potential Biomarker of the Disease Severity in Psoriatic Patients with or without Psoriatic Arthritis Treated with Methotrexate
Authors: ahmed Elziaty Samira , Fakkar Nehal M Zu El , Abd elsabour Hala Mohamed , Soltan Marwa Yassin 
Published: August 2023

Abstract

Introduction
Psoriasis is an inflammatory disease of a complex pathogenesis with its typical cutaneous symptoms are papules& plaques covered with silvery scales and arthritis is one of its most common complications. The biological role of chitinase-3-like protein 1 (YKL-40) remains unknown. It is suggested that this protein takes part in processes such as proliferation, inflammation, angiogenesis and tissue remodelling.

Aim
To investigate the serum level of YKL-40 in psoriatic patients with or without psoriatic arthritis and to study the effect of treatment with methotrexate on the serum levels of YKL-40.

Material and methods
The study was performed on 40 patients with psoriasis vulgaris with or without psoriatic arthritis. All patients showed the clinical signs of psoriasis vulgaris with or without psoriatic arthritis. The diagnosis of cutaneous psoriasis was made clinically based on the characteristic lesions and scored according to Psoriasis Area and Severity Index (PASI) and, additionally, the Body Surface Area (BSA). Psoriatic arthritis patients had fulfilled the diagnostic criteria defined by the classification of Psoriatic Arthritis (CASPAR) criteria. The severity of psoriatic arthritis was assessed using DAPSA Score. Blood samples were taken to measure the serum concentration of YKL-40.

Results
YKL-40 serum levels were significantly higher in patients with psoriatic arthritis, compared to patients with psoriasis only & a significant reduction inYKL-40 levels in both groups, psoriasis patients with and without psoriatic arthritis, after receiving methotrexate treatment. There was a positive correlation between serum YKL-40 and PASI.

Conclusions
YKL-40 can be a useful biomarker for assessment of the disease severity in psoriatic patients with or without psoriatic arthritis. It also detects the efficacy of treatment with methotrexate.
The Role of Human Papilloma Virus in the Pathogenesis of Sinonasal Inverted Papilloma; A Metanalytical Study
Authors: Hakim Ehab Kamal , Hamdy Tarek Abd Elhamid , Mikahail Peter Milad , Abdelhameed Abdelhameed Hassan 
Published: August 2023

Abstract

Background
Sinonasal inverted papilloma (SNIP) is a benign and relatively rare tumor of the nasal cavity and paranasal sinuses, most commonly originates from the lateral nasal wall or maxillary sinus from the schneiderian sinonasal epithelium. There is a male predominance with a male-to-female ratio of 3.4:1. Sinonasal Squamous Cell Carcinoma (SCC) associated with IP has an incidence of approx. 0.38 cases/million persons/year. Patients with carcinoma in IP are older than those IP patients without carcinoma. Some authors assume an influence of Human Papilloma Virus (HPV) subtyping. Transcripts of HPV DNA were found in malignant IP.

Objective
To perform a meta-analytical study to determine the relationship between human papilloma virus and the occurrence of sinonasal inverted papilloma.

Patients and Methods
The review will be restricted to RCTs, clinical trials, and comparative studies, either prospective or retrospective, which studied the outcome of Negative HPV group versus Positive HPV group of patients.

Data Sources
Medline databases (PubMed, Medscape, ScienceDirect. EMF-Portal) and all materials available in the Internet till 2021.

Data Extraction
If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, and adequate information and defined assessment measures.

Results
In our study HPV positive cases were (23.6%) (107/ 452) among SNIP patients. Malignant SNIP rate was (10.8%) (49/ 452). HPV positive cases among malignant SNIP patients was (51.02%) (25/49).

Conclusion
In this meta-analytical study HPV positive cases were (23.6%) (107/ 452) among SNIP patients. Malignant SNIP rate was (10.8%) (49/ 452). Though the etiology of SNIP remains controversial, the studies reviewed in this study indicate a role for HPV infection. Further studies in the future regarding the impact of other risk factors on the occurrence of SNIP would be of value, these factors include angiogenic factors, environmental factors, genetic, viral and chronic sinonasal inflammation.
Assessment of Pragmatic Aspect of Language in Children Diagnosed with Attention Deficit Hyperactivity Disorder
Authors: Abdalla Eman Abdallah Fadel , Hassan Sabah Mohamed , Boshnaq Maha Hussein 
Published: August 2023

Abstract

Background
Assessment of the pragmatic language development in the Arabic speaking societies was a competence in the previous years. Recently, an Egyptian Arabic Pragmatic Language Test was developed (EAPLT). The relation between ADHD and language is especially intuitive in young children. No previous study used the EAPLT to evaluate pragmatic aspect of language in children with ADHD.

Aim
This study aimed to assess the pragmatic aspect of language in children with ADHD.

Methods
A case control study design was used. Fifty patients with ADHD were enrolled randomly from 4 to 8 years old and a normal group of children with the same age and number randomly selected by systemic random sampling from classrooms of different schools in Cairo. Data regarding the child’s age, sex, IQ, mental age, the expressive and the receptive language ages by the Modified PLS4, the pragmatic language age range, percentile, the acquired and the delayed pragmatic language skills according to EAPLT were collected.

Results
Results showed that Language in general was affected in children diagnosed with ADHD, receptive and expressive language age was significantly different than the normal group (p value for receptive=0.017) (p value for expressive=0.024). In the ADHD group 25 children (50%) of the group showed delayed receptive language, and 28 children (56%) of them showed delayed expressive language. The pragmatics aspect of language assessment (p &lt; 0.001) showed significant difference between ADHD and control groups in almost all aspect of pragmatics. Also in conversation skills the results (p &lt; 0.001) showed significant difference between ADHD and control group.

Conclusion
This study showed that children with ADHD had a delayed language, pragmatics and conversational skills compared to normal controls within the same age and IQ.
Success and Complication Rates of Different Techniques and Materials Used for Nasal Dorsal Augmentation in Rhinoplasty
Authors: Fatallah Eman Soliman , Shafik Amr Gouda , Mohamed Mohamed Naguib , Mady Ossama Mustafa 
Published: August 2023

Abstract

Background
Autologous materials, homograft and alloplastic implants are commonly used in nasal dorsal augmentation. So far, there is no satisfactory evidence to ascertain the safest, efficient, and superior in aesthetic outcomes among different materials. Thus, we aimed to conduct a systematic review and metaanalysis (SR, MA) of published literature to review rates of outcomes and complications of different materials used for nasal dorsal augmentation, in trial for better future surgical results.

Methods
Thirteen electronic databases were searched from inception through December 2018 and a manual search in October 2019.

Results
A total of 280 eligible studies were included, of which 165 articles were included in the meta-analysis. Compared to others, alloplastic expanded polytetrafluoroethylene (alloplastic e-PTFE) was considered first place, for having the highest graft scores in most of its outcomes; secondary deformity, resorption, patients’ satisfaction, displacement, extrusion, seroma, graft deviation, swelling, and hematoma outcomes with rates of (2%, 0.6%, 96.5%, 1.3%, 1.2%, 1%, 1%, 0.8%, 0.8%)respectively. Alloplastic silicone came after e-PTFE, for its superior results in revision rhinoplasty, success rate, aesthetic function, and scarring outcomes (4.1%, 99.9%, 98.8%, 2.7%) respectively. Autologous bone graft came at the last place as it had the least graft scores in patients’ satisfaction, displacement, perforation, and hematoma outcomes (50.7%, 9.3%, 8.3%, 5.4%)respectively. Autologous diced cartilage was superior in those outcomes; edema, bruising, and donor site complications (7.1%, 7.4%, 4.4%) respectively. Autologous costal cartilage had the highest graft scores in necrosis and graft exposure outcomes (4.3% and 1.9%), while it had the lowest graft scores in warping and success rate (7.1% and 87.3%). Autologous auricular cartilage had the highest graft scores in warping and foreign body reaction outcomes (1.4% and 6.3%), while it had the lowest graft scores in nasal obstruction and donor site complications rate (72.7% and 33.3%). Infection was the most common reported complication in MA, where autologous alar cartilage had the lowest infection rate of 0.2%, unlike alloplastic Medpor recorded the highest risk of 6.6%.

Conclusions
Regarding our results, we concluded that alloplastic e-PTFE yielded superior position in comparison to other materials, that would succeed as an alternative to convential autologous grafts, as had superior results in most of nasal dorsal augmentation outcomes. On the other hand, autologous bone graft was in the last place in all its outcomes. Future studies are needed to improve reporting of races variety, follow-up times, and diverse participants, as to resolve uncertainty regarding the ideal material for dorsal augmentation in rhinoplasty, with concentrating on proper assessment of races variety, which will improve selecting the proper graft implant.
Cochlear Implantation or Stapes Surgery in Far Advanced Otosclerosis
Authors: Abd El-Aziz Hanaa Sabry Hadaey , Abdelhamid Elnashar Abdelhamid , Kamal Ehab , Teaima Ahmed 
Published: August 2023

Abstract

Background
Otosclerosis is a process of bone resorption of the labyrinthine capsule followed by reparative deposition of new, immature sclerotic bone. It usually occurs during the postlingual period between the second and fifth decade of life. The most commonly affected location is around the oval window (fenestral otosclerosis), which results in conductive hearing loss due to stapes footplate fixation. As it undergoes a maturation process, the sclerotic bone increases in size and depth.

Objective
To compare the hearing outcomes and complications of stapes surgery vs cochlear implantation in patients with far advanced otosclerosis.

Data Sources
Medline databases (PubMed, Medscape, Scopus, Google Scholar, Cochrane, ScienceDirect. EMF-Portal) and all materials available in the Internet till 2021.

Data Extraction
If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls, and adequate information and defined assessment measures.

Patients and Methods
The current review followed the guidelines of preferred reporting items for systematic reviews and meta-analysis statement 2009 (PRISMA). The detailed steps of methods were described elsewhere as well as PRISMA checklist.

Results
The results of this meta-analysis show that comparing the outcomes and complications of cochlear implantation and stapes surgery in far advanced otosclerosis patients have different results, in some of them there was a highly favorable and recommended procedure than the other, other results declared no significant difference in postoperative outcomes.

Conclusion
Both Stapes surgery and CI are reliable treatment options for FAO with very close success rates. Statistics of CI are greater than Stapes surgery and CI has a consistent improvement in speech discrimination scores in comparison to Stapes surgery. Patients must receive adequate counseling regarding all the factors mentioned above and the decision must be made by surgeons and the informed patients.