bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal guidance whale optimization algorithm and hybrid deep learning networks for land use land cover classification
Authors: Vinaykumar V. N. , Babu J. Ananda , Frnda Jaroslav 
Published: January 2023

AbstractSatellite Image classification provides information about land use land cover (LULC) and this is required in many applications such as Urban planning and environmental monitoring. Recently, deep learning techniques were applied for satellite image classification and achieved higher efficiency. The existing techniques in satellite image classification have limitations of overfitting problems due to the convolutional neural network (CNN) model generating more features. This research proposes the optimal guidance-whale optimization algorithm (OG-WOA) technique to select the relevant features and reduce the overfitting problem. The optimal guidance technique increases the exploitation of the search technique by changing the position of the search agent related to the best fitness value. This increase in exploitation helps to select the relevant features and avoid overfitting problems. The input images are normalized and applied to AlexNet–ResNet50 model for feature extraction. The OG-WOA technique is applied in extracted features to select relevant features. Finally, the selected features are processed for classification using Bi-directional long short-term memory (Bi-LSTM). The proposed OG-WOA–Bi-LSTM technique has an accuracy of 97.12% on AID, 99.34% on UCM, and 96.73% on NWPU, SceneNet model has accuracy of 89.58% on AID, and 95.21 on the NWPU dataset.
Exploring the role of green animation advertising influencing green brand love and green customer citizenship behavior
Authors: Zhang Yipin , Yang Yi-Chun 
Published: January 2023

AbstractThis study applied the theory of stimulus–organism–response to test the role of green animation advertising influencing green brand love and green customer citizenship behavior. We used questionnaire survey and the target are those who having the experience of seeing the Apple’s animation advertisement “Earth Day” in China. Finally there were 516 effective samples gathered for analysis. The result indicated that reliability, attractiveness and informativity are the antecedents of green brand love. Green brand love is positively related to green customer citizenship behavior. In addition, the result confirmed the significant mediating effect of green brand love between reliability, attractiveness, informativity and green customer citizenship behavior. This research was conducted only in Apple’s animation case. Hence, the results may not be generalizable to other contexts. Future research can apply the experimental methods and manipulate different forms of green advertising animation to generalize the findings in this area.
Marital dissolution and associated factors in Hosanna, Southwest Ethiopia: a community-based cross-sectional study
Authors: Asfaw Likawunt Samuel , Alene Getu Degu 
Published: January 2023

Abstract
Background
Marriage dissolution, divorce, or separation from a spouse or common-law partner is a serious public health concern due to its increasing prevalence and devastating health and socio-economic consequences. Evidence suggests an increased risk of marital instability in Ethiopia. In addition, the extent of marital dissolution and other related factors have increased in the study area. Despite these, the prevalence of marital dissolution and the influence of associated factors (main reason for marriage, and parental history of marital dissolution) on marital dissolution has not been assessed in the study area. Therefore, the aim of this study was to investigate the prevalence of marital dissolution and its associated factors among residents of Hosanna town in southwestern Ethiopia in 2022.

Methods
We conducted a community-based cross-sectional study among 459 randomly selected Hosanna Township residents. We used structured questionnaires to collect data. Descriptive statistics and logistic regression were performed to describe the data and test-associated factors, respectively. A p-value less than 0.05 was used to define statistical significance. We used STATA 14 and IBM SPSS 25.0 computer packages to process data.

Results
Out of the 459 potentially eligible individuals, 450 participants properly responded to the questionnaires yielding a response rate of 98.04%. Of these, 218 (52.9%) were female. The commonly reported reason for marriage was to have children 150 (36.9%). The prevalence rate of marital dissolution was 26.0% (95% CI: (21.7%, 30.3%)). The participant's level of education and the primary reasons (motives) why they get married were statistically significantly associated with marital dissolution. The odds of marital dissolution was higher among participants who completed secondary education (AOR = 3.2, 95% CI = 1.26–8.17) compared to those having no formal education. The participants who married for companionship reasons (AOR = 0.31, 95% CI = 0.11–0.83) had significantly lower odds of marriage dissolution compared with those who married for financial security.

Conclusions
In this study, the prevalence of marital dissolution was high. The participant’s level of education and the primary reasons (motives) why they getting married were significantly associated with marital dissolution. Therefore, an integrated, community-based approach should be developed to prevent marital dissolution.
The clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses
Authors: Chen Yungchang , Sun Hao , Deng Yanhong , Ma Yutong , Huang He , Liu Yang , Zhang Yaru , Zhang Hongyu , Ye Sheng , E Mingyan , Guo Hongqiang , Wu Mengmeng , Wu Chunman , Pu Xingxiang , Chen Xinggui , Liang Chaoyong , Ou Qiuxiang , Weng Huawei , Wu Xue , Shao Yang , Gu Anxin , Lin Tongyu 
Published: January 2023

AbstractBRAF mutations are the oncogenic drivers in colorectal cancer and V600 mutations (Class1), which lead to RAS-independent active monomers, are the most common mutation types. BRAF non-V600 mutants can be further classified as RAS-independent active dimers (Class2) and RAS-dependent impaired kinase (Class3). We retrospectively reviewed the mutational profiles of 328 treatment-naïve colorectal tumors with BRAF mutations detected using capture-based hybrid next-generation sequencing targeting 400 + cancer-related genes. The clinical and genetic distinctions of patients harboring Class1/2/3 BRAF mutations were investigated, which revealed that tumors with Class1 BRAF mutations showed more unique genomic profiles than those with Class2/3 mutations. Also, by using an external dataset from cBioPortal, we demonstrated that patients with Class3 BRAF mutations had the best survival outcomes compared to the other two subgroups. These findings promoted the development of anti-BRAF strategies by distinguishing BRAF mutant subgroups.
PET-based radiomics visualizes tumor-infiltrating CD8 T cell exhaustion to optimize radiotherapy/immunotherapy combination in mouse models of lung cancer
Authors: Zhang Ying , Hu Hui-Hui , Zhou Shi-Hong , Xia Wu-Yan , Zhang Yan , Zhang Jian-Ping , Fu Xiao-Long , Yu Wen 
Published: January 2023

Abstract
Background
Cumulative preclinical and clinical evidences showed radiotherapy might augment systemic antitumoral responses to immunotherapy for metastatic non-small cell lung cancer, but the optimal timing of combination is still unclear. The overall infiltration and exhausted subpopulations of tumor-infiltrating CD8+ T cells might be a potential biomarker indicating the response to immune checkpoint inhibitors (ICI), the alteration of which is previously uncharacterized during peri-irradiation period, while dynamic monitoring is unavailable via repeated biopsies in clinical practice.

Methods
Basing on tumor-bearing mice model, we investigated the dynamics of overall infiltration and exhausted subpopulations of CD8+ T cells after ablative irradiation. With the understanding of distinct metabolic characteristics accompanied with T cell exhaustion, we developed a PET radiomics approach to identify and visualize T cell exhaustion status.

Results
CD8+ T cell infiltration increased from 3 to 14 days after ablative irradiation while terminally exhausted populations significantly predominated CD8+ T cells during late course of this infiltrating period, indicating that 3–7 days post-irradiation might be a potential appropriate window for delivering ICI treatment. A PET radiomics approach was established to differentiate T cell exhaustion status, which fitted well in both ICI and irradiation settings. We also visualized the underlying association of more heterogeneous texture on PET images with progressed T cell exhaustion.

Conclusions
We proposed a non-invasive imaging predictor which accurately assessed heterogeneous T cell exhaustion status relevant to ICI treatment and irradiation, and might serve as a promising solution to timely estimate immune-responsiveness of tumor microenvironment and the optimal timing of combined therapy.
BEGL: boundary enhancement with Gaussian Loss for rock-art image segmentation
Authors: Bai Chuanping , Liu Yangyang , Zhou Pengbo , Wang Xiaofeng , Zhou Mingquan 
Published: January 2023

Abstract
Rock-art has been scratched, carved, and pecked into rock panels all over the world resulting in a huge number of engraved figures on natural rock surfaces that record ancient human life and culture. To preserve and recognize these valuable artifacts of human history, 2D digitization of rock surfaces has become a suitable approach due to the development of powerful 2D image processing techniques in recent years. In this article, we present a novel systematical framework for the segmentation of different petroglyph figures from 2D high-resolution images. The novel boundary enhancement with Gaussian loss (BEGL) function is proposed aiming at refining and smoothing the rock-arts boundaries in the basic UNet architecture. Several experiments on the 3D-pitoti dataset demonstrate that our proposed approach can achieve more accurate boundaries and superior results compared with other loss functions. The comprehensive framework of petroglyph segmentation from 2D high-resolution images provides the foundation for recognizing multiple petroglyph marks. The framework can then be extended to other cultural heritage digital protection domain easily.
Preoperative Ahlbäck radiographic classification grade significantly influences clinical outcomes of double level osteotomy for osteoarthritic knees with severe varus deformity
Authors: Nakayama Hiroshi , Kanto Ryo , Onishi Shintaro , Amai Kenta , Ukon Ryosuke , Tachibana Toshiya , Yoshiya Shinichi , Iseki Takuya , Morimoto Shota , Iseki Tomoya 
Published: January 2023

AbstractPurposeThe purpose of this study was to examine the relationship between preoperative Ahlbäck radiographic classification grade and the clinical outcomes of double level osteotomy (DLO) performed for osteoarthritic knees with severe varus deformity.MethodsThe study population comprised a consecutive series of 99 knees (68 patients) for which DLO was performed and follow‐up results for a minimum of two years were available. The Ahlbäck radiographic classification system was used to determine the osteoarthritic grade. The following radiological parameters for alignment and bone geometry were measured: mechanical lateral distal femoral angle (mLDFA), mechanical medial proximal tibial angle (mMPTA), joint‐line convergence angle (JLCA), and mechanical tibiofemoral angle (mTFA). Clinical results were assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the International Knee Documentation Committee (IKDC) subjective score preoperatively and at 2 years after surgery. Difference between preoperative and postoperative measurements as well as relationship between Ahlbäck grade and radiological/clinical results were statistically assessed.ResultsThe average age of the study participants was 60.9 ± 6.2 years and the mean follow‐up period was 45.4 ± 15.2 months. Each of the radiological parameters exhibited preoperative abnormal values. Knees with Ahlbäck grade 3 and 4 osteoarthritis exhibited significantly greater JLCA and mTFA than grade 1 knees. Two years post‐surgery, all radiological parameter values measured within a normal range. Clinical evaluation showed significant improvement in KOOS after surgery. Analysis of the relationship between Ahlbäck grade and clinical score showed that the 2‐year postoperative KOOS scores in grade 3 and 4 osteoarthritic knees were significantly lower than grade 1 knees (with the mean 2‐year KOOS scores of 350.0 ± 79.9, 317.9 ± 78.3, and 420.2 ± 42.9, respectively).ConclusionsWhile DLO may produce significant radiological and clinical improvement in knees with joint space obliteration, Ahlbäck grade 3 and 4 osteoarthritic knees associated with larger JLCA and mTFA showed less satisfactory clinical results compared to grade 1 knees. Level of Evidence: IV case series.
A systematic review of transphyseal ACL reconstruction in children and adolescents: comparing the transtibial and independent femoral tunnel drilling techniques
Authors: Petersen Wolf , Bierke Sebastian , Stöhr Amelie , Stoffels Thomas , Häner Martin 
Published: January 2023

AbstractPurposeAim of this systematic review was to analyze the outcome after transphyseal ACL reconstruction in children and adolescents regarding the femoral drilling technique.MethodsA systematic literature search was carried out in various databases on studies on transphyseal ACL reconstruction in children and adolescents. The literature search was limited to the last 20 years. Primary outcome criterion was the failure rate. Secondary outcome criteria were growth disturbances such as leg length discrepancies or deformities and clinical scores.The present study was registered prospectively (www.crd.york.ac.uk/PROSPERO; CRD42022345964).ResultsA total of 22 retrospective or prospective case series (level 4 evidence) were identified that reported on transphyseal ACL reconstruction in children and adolescents. The overall failure/rupture rate after transphyseal ACL reconstruction was 11.0%. The overall ACL rupture rate of the contralateral side was 9.7%. No statistical significant difference in the failure rates between independent and transtibial drilling techniques could be detected ((p = 0.76/p = 0.28)). Furthermore no statistical significant differences in the rate of reported growth disturbances between independent and transtibial drilling techniques were shown (p = 0.15). The reported clinical scores at follow‐up (mean follow‐up 5.05 years) revealed good to very good results.ConclusionThis systematic review demonstrates that children and adolescents have a relatively high failure rate after transpyseal ACL reconstruction without any statistically significant differences between independent or transtibial drilling techniques regarding reruptur rates or the rate of growth disturbances. The results of this systematic review warrant a comparison of both techniques for femoral tunnel drilling in a controlled randomized trial.
Cordyceps militaris polysaccharides: preparation and topical product application
Authors: Kanlayavattanakul Mayuree , Lourith Nattaya 
Published: January 2023

Abstract
Background
Topical product derived from the fungus Cordyceps militaris was explored as a feasible method for an industrial practice.

Results
The mycelium residue of C. militaris that was industrial biotechnological produced was extracted with water at different time conditions under ambient temperature, filtered and lyophilized. The extracts were all light to dark brown powder. The 24 h extraction was significantly (p < 0.01) highest in an extractive yield and total polysaccharides content (TPC) (43.33 ± 0.99% and 144.02 ± 2.06 mg glucose/g crude extract). This extract was proved to be stable following an accelerated stability test with the insignificant (p > 0.05) reduction of TPC (4.95 ± 2.23%). Topical product containing the extract were developed. Skin care preparation containing 0.2% extract was exhibited as the appropriated amount giving the stable cream. The developed C. militaris polysaccharide cream was confirmed safe and gained more than 70% of the overall preferences examined in 20 female volunteers.

Conclusions
Cordyceps militaris mycelium residue is a beneficial source for pharmaceutical products. The C. militaris polysaccharides extract was prepared and qualified in terms of active content and stability. The extract was shown to be compatible with the available cosmetic ingredients. The safe and preferred C. militaris polysaccharides skin care cosmetics was developed. Accordingly, C. militaris polysaccharides skin care cosmetics that meets all the quality characters which are stable, safe, usable and efficient.
Cancer incidence and mortality in patients diagnosed with heart failure: results from an updated systematic review and meta-analysis
Authors: Camilli Massimiliano , Chiabrando Juan Guido , Lombardi Marco , Del Buono Marco Giuseppe , Montone Rocco Antonio , Lombardo Antonella , Crea Filippo , Minotti Giorgio 
Published: January 2023

Abstract
Background
Several cohort studies aimed at demonstrating an increased risk of cancer incidence and mortality in patients with a pre-existing diagnosis of heart failure (HF); however, conflicting results have been reported that call for systematic review and meta-analysis.

Methods
We conducted a systematic search of multiple databases from their inception through July 2022 and retrieved only papers reporting hazard ratios (HR). Random and fixed-effects models were fit for the study duration.

Results
The analysis included nine cohort studies for a total of 515′041 HF cases and 1′365’452 controls without HF. Although high heterogeneity among studies was observed, the HR for incident cancer in HF patients was statistically significant (1.45, 95% CI 1.31–1.61, p < 0.0001), which was confirmed by sensitivity analyses; however, by analyzing the few papers reporting HRs for cancer mortality, no significant difference between HF and non-HF patients could be detected (HR 2.03, 95% CI [0.93–4.43], p = 0.0736). Further scrutiny of studies with adjusted HRs, when available, confirmed that cancer incidence was significantly increased in patients with HF, as was cancer mortality as well.

Conclusions
This meta-analysis shows that HF patients are at an increased risk of incident cancer. Increased mortality could not be firmly demonstrated by the available data. Our results call for inclusion of cancer-related endpoints in HF trials to adequately address this important clinical issue.
The Burden of Surviving Childhood Medulloblastoma: A Population-Based, Matched Cohort Study in Ontario, Canada
Authors: Coltin Hallie , Pequeno Priscila , Liu Ning , Tsang Derek S. , Gupta Sumit , Taylor Michael D. , Bouffet Eric , Nathan Paul C. , Ramaswamy Vijay 
Published: January 2023

PURPOSE Survivors of childhood medulloblastoma suffer from substantial late effects. We characterized these sequelae using real-world health services data in a population-based cohort of medulloblastoma survivors. METHODS All 5-year medulloblastoma survivors diagnosed age < 18 years between 1987 and 2015 in Ontario, Canada, were identified and matched 1:5 with population controls. Index date was 5 years from latest pediatric cancer event. Linkage to provincial administrative health data allowed for comparison of cumulative incidences of several adverse outcomes. RESULTS Two hundred thirty survivors, 81.3% of whom had received craniospinal irradiation, were matched with 1,150 controls. The 10-year postindex cumulative incidence of all-cause mortality was 7.9% (95% CI, 3.9 to 11.8) in survivors versus 0.6% (95% CI, 0.1 to 1.1) in controls (hazard ratio [HR], 21.5; 95% CI, 9.8 to 54.0). The cumulative incidence of stroke was higher in survivors (4.8%; 95% CI, 2.2 to 9.0) compared with controls (0.1; 95% CI, 0.01 to 0.7; HR, 45.6; 95% CI, 12.8 to 289.8). Hearing loss requiring an amplification device was present in 24.9% (95% CI, 18.8 to 31.4) of survivors versus 0.3% (95% CI, 0.1 to 1.0) of controls (HR, 96.3; 95% CI, 39.7 to 317.3). Disability support prescription claims were submitted by 44.5% (95% CI, 37.1 to 51.6) of survivors versus 5.5% (95% CI, 4.2 to 7.1) of controls (HR, 10.0; 95% CI, 7.3 to 13.6). Female survivors were significantly less likely to deliver a liveborn child compared with controls (HR, 0.2; 95% CI, 0.1 to 0.7). CONCLUSION Survivors of medulloblastoma have significant long-term medical sequelae, increased all-cause mortality, and are frequently dependent on disability supports. Efforts to reduce the toxicity of current therapy, specifically incorporating molecularly informed risk stratification to spare low- and intermediate-risk survivors the toxicity of treatment, are urgently needed. These findings should prompt a re-evaluation of our current treatment approaches where research focused on late-effect interventions should be prioritized. [Media: see text]
Formal and Informal Alliances between Iberians and Natives in the Heart of Late Eighteenth-Century South America
Authors: Carvalho Francismar Alex Lopes de 
Published: January 2023

AbstractFor decades, historiography on the Iberian empires has suggested that peace treaties between Europeans and autonomous Native groups incorporated both Indigenous “nations,” understood as cohesive units, and Native lands into the monarchy. Drawing on extensive archival evidence and recent borderlands scholarship, this article suggests that written agreements had a limited impact on interethnic frontier relations. First, because informal relations shaped by Indigenous patterns of diplomacy were far more important to the success of alliances. Second, because alliances were often made with autonomous tolderías, not with homogeneous “nations.” And third, because Natives by no means identified their ethnic territories with Crown possessions, but continued to independently exploit Iberian rivalries in order to achieve more favorable conditions for themselves. This article focuses on the frontier between the Spanish province of Paraguay and the Portuguese captaincy of Mato Grosso.
Style and Rebus in an Emergent Script from Bolivia: The Koati Variant of Andean Pictographic Writing
Authors: Hyland Sabine 
Published: January 2023

Abstract
Andean pictographic writing, once considered the creation of foreign missionaries, is now recognized as a series of locally developed scripts that emerged after contact with alphabetic writing. However, the role of stylistic variation within the Andean pictographic scripts is little understood, nor has the rebus-based glottography of the system’s phonetic signs been fully studied. This article examines the Koati variant of Andean pictographic script from Bolivia’s Island of the Moon, based in part on a newly found pictographic manuscript preserved on animal hides in Harvard University’s Peabody Museum. It analyzes how script styles in the Titicaca area correspond to regional groups and explores the nature of rebus signs in the Koati variant, identifying the principles underlying successful homonymic equivalences. Many of the characters in Andean pictographic writing appear to draw from a repository of Indigenous visual signs that predate the Spanish invasion; research into the emergent pictorial scripts of Peru and Bolivia may provide insights into the meaning of visual signs in other forms of Andean inscription, such as ceramics and khipus.