bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of Infection After Total Knee or Hip Arthroplasty After Receipt of Multiple Corticosteroid or Hyaluronic Acid Injections
Authors: Raymond Hayley E. , Barbera Joseph P. , Shah Kush C. , Zubizarreta Nicole , Huang Hsin-Hui , Poeran Jashvant , Chen Darwin D. , Moucha Calin S. , Hayden Brett L. 
Published: August 2023

Background:
Few studies have assessed the relationship between the quantity of preoperative corticosteroid injections (CSIs) or hyaluronic acid injections (HAIs) and postoperative infection risk after total knee or hip arthroplasty (TKA, THA). We aimed to (1) determine whether the number of injections administered before TKA/THA procedures is associated with postoperative infections and (2) establish whether infection risk varies by injection type.

Methods:
This retrospective cohort study included 230,487 THAs and 371,511 TKAs from the 2017 to 2018 Medicare Limited Data Set. The quantity of CSI or HAI, defined as receiving either CSI or HAI ≤2 years before TKA/THA, was identified and categorized as 0, 1, 2, or >2. The primary outcome was 90-day postoperative infection. Multivariable regression models measured the association between the number of injections and 90-day postoperative infection. Odds ratios and 95% confidence intervals were reported.

Results:
The percentage of THA patients receiving 1, 2, and >2 preoperative CSIs was 6.1%, 1.6%, and 0.8%, respectively. Receiving >2 CSIs within 2 years before THA was associated with higher odds of 90-day postoperative infection (odds ratios = 1.74, 95% CI = 1.11 to 2.74, P = 0.02). The percentage of TKA patients receiving 1, 2, and >2 CSIs was 3.0%, 1.2%, and 1.1%, respectively. For HAIs in TKA patients, percentage receiving injections was 98.3%, 0.6%, 0.2%, and 0.9%, respectively. Quantity of CSIs or HAIs administered was not associated with postoperative infection among TKA patients.

Conclusion:
Patients receiving >2 injections before THA had higher odds of 90-day postoperative infection. This finding was not observed in TKA patients. These results suggest that the use of >2 injections within 2 years of THA should be avoided.
DIGITAL LITERACY DEVELOPMENT: ASSESSING THE EFFICACY OF ONLINE LEARNING PLATFORMS IN ENHANCING STUDENTS' INFORMATION FLUENCY
Authors: Reyaz Ahmad Bhat  
Published: August 2023

Abstract
Digital literacy is a critical skill in today's information-rich society. This research paper investigates the impact of online learning platforms on students' information fluency—a crucial component of digital literacy. The study evaluates the effectiveness of various online tools and resources in improving students' abilities to locate, evaluate, and synthesize digital information. Through a comprehensive assessment and analysis, the paper aims to contribute valuable insights to the field of education and technology-enhanced learning.
Key words: Digital literacy, technology –enhanced learnin
RESISTÊNCIA BACTERIANA DEVIDO AO USO INDISCRIMINADO DE ANTIBIÓTICOS NA PANDEMIA DA COVID-19
Authors: Mazola Helenilda , Vieira Renan Luiz Albuquerque , Dos Santos Lucas Bastos , De Souza Andréa dos Santos , Jesus Thamires Soares Ricardo , Bonsucesso Josemário Santana , Andréa Maria Vanderly , Cavalcante Ana Karina da Silva 
Published: August 2023

Resistência antimicrobiana resulta do acúmulo de mutações que ocorrem no genoma microbiano, ao longo de gerações. O fenômeno se caracteriza pela capacidade das linhagens mutantes de resistirem aos mecanismos de ação dos fármacos que se destinam a sua inativação. O uso indiscriminado de antibióticos na pandemia da COVID-19 contribuiu para o aparecimento de resistência bacteriana. Diante do exposto, o objetivo neste estudo consiste em investigar por meio de revisão de literatura a possibilidade de aquisição de resistência bacteriana frente ao uso de antibióticos durante a pandemia da COVID-19. E como objetivos específicos: investigar a banalização ao aumento do uso de antibiótico durante a pandemia da COVID-19; abordar os riscos associados à resistência bacteriana; investigar a possibilidade de coinfecção bacteriana em pacientes da COVID-19; identificar a classe de antibiótico mais prescrito; abordar medidas adequadas para a prevenção e tratamento da COVID-19. Para tanto, foram realizadas buscas de artigos nas bases eletrônicas PubMed, Scielo e LILACS utilizando os descritores em português
(Antibiótico; Resistência bacteriana; COVID-19) e em inglês (Antibiotic; Bacterial resistance; covid-19). Foram aplicados critérios de inclusão como: artigos relacionados ao tema, disponíveis na íntegra pelo meio online, publicados nos últimos 5 anos, publicações escritas em idioma português e inglês, pesquisas laboratoriais, ensaios clínicos, revisões de literatura e sistemáticas, randomizado, relato ou série de casos clínicos. Como critérios de exclusão: artigos que não abordassem a temática selecionada. O uso indiscriminado do antibiótico elevou o aumento da resistência bacteriana na pandemia da COVID-19, em particular a azitromicina que demonstrou efeitos expressivos, apresentando em todo o mundo impacto no aumento de novas bactérias resistentes à antibióticos, sendo necessária uma maior padronização clínica e controle do uso desses medicamentos somente em pacientes com coinfecção bacteriana comprovada, no intuito de evitar e controlar o aumento da resistência bacteriana. Esse estudo terá uma contribuição significativa na saúde, pois, tem o intuito de contribuir com a saúde de modo geral e entender de fato que o uso indiscriminado de antibióticos está gerando uma resistência bacteriana.
Kepemimpinan Pastoral Dalam Mengelola Konflik Jemaat Di Gereja Lokal Berdasarkan Markus 10:41-45
Authors: Putra Jusaktri Susanto , Hutabarat Christiani , Budiyanto Henoch 
Published: August 2023

This research explores the topic of pastoral leadership in managing congregational conflict in local churches, drawing insights from the passage in Mark 10:41-45. The aim is to understand the implications of this biblical text for contemporary pastoral leaders in dealing with conflict within their congregations. The paper begins by introducing the passage in Mark 10:41-45, highlighting its relevance and significance in the context of pastoral leadership and conflict management. It then examines the background and context of the text, followed by an analysis of its content and central message. This research explores the implications for pastoral leaders in managing congregational conflict in local churches. It emphasizes the importance of pastoral leaders adopting a servant-like attitude and prioritizing the needs and interests of others. This research emphasizes the importance of pastoral leaders embodying the principles of servant leadership and selfless service in their roles. This paper encourages pastoral leaders to reflect on these principles and apply them in their leadership practice in the context of their local churches.

Penelitian ini mengeksplorasi topik kepemimpinan pastoral dalam mengelola konflik jemaat di gereja-gereja lokal, mengambil wawasan dari bagian dalam Markus 10:41-45. Tujuannya adalah untuk memahami implikasi teks alkitabiah ini bagi para pemimpin pastoral kontemporer dalam menghadapi konflik di dalam jemaat mereka. Makalah ini dimulai dengan memperkenalkan perikop dalam Markus 10:41-45, menyoroti relevansi dan signifikansinya dalam konteks kepemimpinan pastoral dan manajemen konflik. Kemudian memeriksa latar belakang dan konteks teks, diikuti dengan analisis isi dan pesan sentralnya. Penelitian ini mengeksplorasi implikasi bagi para pemimpin pastoral dalam mengelola konflik jemaat di gereja-gereja lokal. Hal ini menekankan pentingnya para pemimpin pastoral mengadopsi sikap seperti pelayan dan memprioritaskan kebutuhan dan kepentingan orang lain. Penelitian ini menekankan pentingnya pemimpin pastoral mewujudkan prinsip-prinsip kepemimpinan yang melayani dan pelayanan tanpa pamrih dalam peran mereka. Makalah ini mendorong para pemimpin pastoral untuk merenungkan prinsip-prinsip ini dan menerapkannya dalam praktik kepemimpinan mereka dalam konteks gereja lokal mereka.
EFFICACY OF LACTOSE-FREE FORMULA AS A 24-HOUR MANAGEMENT APPROACH FOR ACUTE DIARRHEA AMONG CHILDREN
Authors: Nitayakul Praewwanit , Jeephet Kornthip , Ngeonmak Thitima 
Published: August 2023

Background: Diarrhea continues to be a prominent contributor to morbidity and mortality among young children under five years, especially in developing nations. Secondary lactose intolerance is a significant complication that can arise from acute diarrhea. However, it can be effectively managed with lactose-free formula.
Objective: This study aimed to compare the rate of diarrhea resolution within a 24-hour period among children receiving lactose-free formula and those receiving lactose-containing formula.
Methods: This retrospective cohort study took place at Naresuan University Hospital and included 153 children aged between one month and five years admitted with acute diarrhea. Participants with bloody mucous diarrhea suspected to be bacterial in nature, positive stool culture, breastfeeding and chronic diarrhea (including cow’s milk protein allergy and inflammatory bowel disease) were excluded. We compared the effectiveness of lactose-free formula (n=48) and lactose-containing formula in improving clinical diarrhea within a 24-hour (n=105).
Results: The study findings indicated the lactose-free formula group demonstrated a statistically significant increase in efficacy, with a 3.90 fold improvement in diarrhea within 24 hours compared with that of the group receiving lactose-containing formula. These results were obtained after the confounding factors were adjusted using multivariable regression analysis. The adjusted relative risk (RR) for a 24-hour improvement in diarrhea was 3.90 (95% CI: 1.91-7.95). However, this study encountered limitations regarding the sample size and accurate measurement of stool output.
Conclusion: Lactose-free formula showed the potential for greater effectiveness in improving acute diarrhea within a 24-hour timeframe compared with lactose-containing formula.
EDUKASI PENTINGNYA SADARI (PEMERIKSAAN PAYUDARA SENDIRI) DAN SADANIS (PEMERIKSAAN PAYUDARA KLINIS) UNTUK DETEKSI DINI KANKER PAYUDARA
Authors: Maghfiroh Ainul , Jati Riani Pradara , Ayuningtyas Fitri 
Published: August 2023

Deteksi dini Kanker payudara salah satunya yaitu dilakukan dengan penerapan SADARI (pemeriksaan payudara sendiri) yang dilakukan secara mandiri dan pemeriksaan payudara klinis yang dilakukan oleh tenaga kesehatan, Pencegahan kanker saat ini memainkan peran kunci dalam perang melawan penyakit. Modifikasi perilaku, serta kesadaran yang lebih besar di kalangan wanita tentang kanker payudara dapat berkontribusi secara signifikan dalam mengurangi kejadian kanker payudara.penyebab tingginya kejadian kanker di Indonesia adalah kondisi lingkungan yang terus menghasilkan zat penyebab kanker dan gaya hidup yang kurang sehat. Pengabdian masyarakat dilakukan kepada remaja putri di Sekolah Menengah Kejuruan Kelas XII, peserta dalam pengabdian masyarakat berjumlah 35 siswa dengan metode pengabdian masyarakat yaitu diskusi, demonstrasi dan tanya jawab, seluruh peserta pengabdian dapat mempraktekan pemeriksaan payudara sendiri dengan benar. pengabdian masyarakat ini penting dilakukan untuk mengurangi kejadian keparahan akibat kanker payudara.
A 〖(2n+9)〗^thDegree Polynomial Approximation Method for Solving Eight Order Linear Boundary Value Problems
Authors: Mutawakilu Ibrahim , Bello Nakone , Aminu Mustafa 
Published: August 2023

Galerking method, Collocation method and least squired method have been used for solving boundary value problems (BVPs) and from practical point of view almost any success of above mention method depends on the selection of basis functions. Also, Adomain decomposition and variational iteration methods have been applied for the solution of BVPs and required respectively calculating the Adomian’s polynomials and Lagrange multipliers. In this paper a simple method of Degree polynomial approximation solution were n is number of successive derivatives of the governing equation is suggested as an alternative of the above mentioned methods. The method consists of first obtaining from the governing equation its n successive derivatives and boundary conditions a linear differential system of equations evaluated at the boundary points. Next, an approximate solution in the form of polynomial of degree with unknown coefficients is assumed. To determine the unknown coefficients, the assumed solution is incorporate into the linear differential system which turns to be a linear system of equation with unknowns which is salvable uniquely. The method is tested for n=5 to four examples. It clear that from tables 3.1 to 3.4 and figures 3.1 to 3.4 the numerical outcomes agree with the exact solution and also better than some existing results in the literatures. it should be also noted that the accuracy of the method can be increased by increased n. All Numerical computation were performed using maple 2016 software.
Increasing transparency in indirect treatment comparisons: is selecting effect modifiers the missing part of the puzzle? A review of methodological approaches and critical considerations
Authors: Freitag Andreas , Gurskyte Laura , Sarri Grammati 
Published: August 2023

Failure to adjust for effect modifiers (EMs) in indirect treatment comparisons (ITCs) can produce biased and uncertain effect estimates. This is particularly important for health technology assessments (HTAs), where the availability of new treatments is based on comparative effectiveness results. Much emphasis has been placed on advancing ITC methods to adjust for EMs, yet whether EMs are appropriately identified for the conduct of ITCs in the first place is unclear. To understand the extent of guidance and requirements for the selection of EMs for ITCs currently available and if and how this guidance is applied in practice, a series of pragmatic reviews of guidance documents from HTA and non-payer organizations, primary published ITC analyses, and prior HTA submissions in two indications (non-small cell lung cancer and psoriasis) was conducted. The reviews showed that current ITC guidance mainly focused on developing analytical methods to adjust for EMs. Some organizations, such as HTA bodies in the UK, France and Germany, recommended the use of literature reviews, expert opinion and statistical methods to identify EMs. No detailed guidance on the selection process or the appropriate literature review approach was found. Similar trends were identified through the database search and review of prior HTA submissions; only few published ITCs and submissions included information on the EM selection process which was either based on findings from the literature, trial subgroup analyses, or clinical input. No reference to a systematic selection approach was found.
There is an urgent need to fill the guidance gap identified across the reviews by including a step in ITC guidelines on how EMs should be identified through systematic reviews, formal expert elicitation, and a quantitative assessment of the EM distribution. Researchers and manufacturers are also encouraged to improve transparent reporting and justification of their selection of EMs to allow for an independent review of the set of factors being considered for adjustment. Both will contribute toward reducing bias in the ITC results and ultimately increase confidence in decision-making.
Knowledge Management for the Marine Energy Industry: PRIMRE
Authors: Whiting Jonathan , Ricardo Castillo Cesar , Weers Jon , Peterson Katie , Peplinski Will , Ruehl Kelley , Copping Andrea , Anderson Megan , Ticona Rollano Fadia , Gilroy Nicholas , Susmarski Paul , Garavelli Lysel , Fields Hanna , Farr Hayley , Morris Sean 
Published: August 2023

Marine energy involves capturing power from ocean currents and waves, and natural gradients of temperature and salinity. In nearly 20 years of modern development, the industry has generated considerable knowledge around resource assessment, site selection, technology design, manufacturing, testing, environmental effects, and standardization. The Portal and Repository for Information on Marine Renewable Energy integrates and connects marine energy knowledge hubs into a comprehensive and connected knowledge ecosystem with the goal of progressing the industry. The seven knowledge hubs include the Marine and Hydrokinetic Data Repository for datasets, Tethys and Tethys Engineering for environmental and technical documents, Marine Energy Projects Database for deployment activities, Marine Energy Software for software, Marine Energy Atlas for geospatial data, and Telesto for development guidance. At an early tumultuous time in the industry, these knowledge management systems organize vocabularies, retain important early lessons from developers, guide research activities internationally, inform permitting decisions for regulators, and provide authoritative sources of information for the public.
An Innovative Five-Step Patient Interview Approach for Integrating Mental Healthcare into Primary Care Centre Services (AlKhathami Approach)
Authors: Dukhail AlKhathami Abdullah 
Published: August 2023

Mental health problems are often inadequately diagnosed and managed in routine primary healthcare (PHC) services. The new Five-Step Patient Interview approach (the AlKhathami approach) is comparable to psychiatric interviews and is more accurate than current screening tools for identifying patients’ degrees of psychological stress. This will assist in integrating the screening and management of psychological stress and common mental health problems among patients seeking PHC services. It is a valid and reliable tool for integrating mental healthcare into PHC and family practice services. The Five-Step approach offers an opportunity to provide mental health services in busy clinics (5–8 min duration). It improves physician-patient communication by encouraging the exploration of patients’ perspectives. It plays a role in controlling chronic organ diseases and physical complaints. It also reduces the frequency of patient health services, enhances the satisfaction of patient healthcare providers, and reduces unnecessary investigations and medications, thereby safeguarding healthcare resources.
Role of Exosomes in Tuberculosis: Looking towards a Future Road Map
Authors: Kumar Barik Sushanta , Turuk Jyotirmayee 
Published: August 2023

Exosomes are generated by the multivesicular degradation of plasma membrane fusion, lysosomal, and extracellular release of intracellular vesicles. The exosome ranges from 30 to 150 nm in size. Exosomes are “bioactive vesicles” that promote intercellular communication. Exosomes contain a variety of biologically active substances packaged with proteins, lipids, and nucleic acids. After any microbe infection into the exosomes, the content of the exosomes changes and is released into the bloodstream. Such type of exosome content could be useful for basic research on exosome biology. Tuberculosis (TB) is a serious infectious disease caused by Mycobacterium tuberculosis (Mtb). During the Mtb infection, the exosomes played an important role in the body’s infection and immune response by releasing several exosome components providing new ideas for diagnosis, prevention, and therapeutic treatment of Mtb infection. The detection of the low abundance of the Mtb numbers or secreted peptides in the serum of TB patients is not possible. The best way of findings for diagnosis and treatment of TB could be possible by the exploration of exosome content analysis through various useful technologies. The study and analysis of exosome content would produce a road map for the future early diagnosis, prognosis estimation, efficacy monitoring, research, and application for TB.
PERAN KOMUNIKASI ANTAR PRIBADI DALAM MEWUJUDKAN KEPRIBADIAN ANAK DENGAN MEDIA PERMAINAN SIMULASI PERAN DI PANTI ASUHAN SAKINAH
Authors: Amalliah Amalliah , Yunita Ria 
Published: August 2023

Forming or realizing a child's personality is not an easy thing and also a very difficult thing.
Children will be formed personality indirectly from the environment around where they live and
grow. At Sakinah Orphanage, the children of the orphanage don't get the love of their family
because they don't have parents and family anymore. And Sakinah orphanage children rarely
interact with other people outside because they have to obey the rules that apply in the
orphanage. This will shape the child's personality to communicate less closely with
administrators, friends. Family communication is important in the role of the child's personality,
so role playing simulation games can provide positive things and increase children's creativity
and interaction effects. With 8 methods of role playing, children will be bombed and directed to
get to know other people's characters or professions or jobs that they usually encounter
everyday. Raising the theme of daily activities makes children more familiar and creative and
dares to give opinions and in particular can improve interpersonal communication between
them.
The Implementation of Nongynecologic Reporting Systems in Cytopathology Laboratories Is Highly Variable: Analysis of Data From a 2020 Supplemental Survey of Participants in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology
Authors: VandenBussche Christopher J. , Nwosu Ann , Souers Rhona , Sundling Kaitlin E. , Brainard Jennifer , Goyal Abha , Lin Xiaoqi , Masood Shala , Nguyen Lananh , Roberson Janie , Tabbara Sana O. , Booth Christine 
Published: August 2023

Context
In recent years, several reporting systems have been developed by national and international cytopathology organizations to standardize the evaluation of specific cytopathology specimen types.

Objective
To assess the current implementation rates, implementation methods, and barriers to implementation of commonly used nongynecologic reporting systems in cytopathology laboratories.

Design
Data were analyzed from a survey developed by the College of American Pathologists Cytopathology Committee and distributed to participants in the College of American Pathologists Nongynecologic Cytopathology Education Program mailing.

Results
Nongynecologic reporting systems with the highest rate of adoption were the Bethesda System for Reporting Thyroid Cytopathology, 2nd edition (74.1%; 552 of 745); the Paris System for Reporting Urinary Cytology (53.9%; 397 of 736); and the Milan System for Reporting Salivary Gland Cytopathology (29.1%; 200 of 688). The most common reason given for not adopting a reporting system was satisfaction with a laboratory's current system. Implementation varied among laboratories with regard to which stakeholders were involved in deciding to implement a system and the amount of education provided during the implementation process.

Conclusions
The implementation of nongynecologic reporting systems in cytopathology laboratories was highly variable.