bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of remineralizing efficiency of two calcium-based non-fluoridated remineralizing agents for the prevention of white spot lesions (WSL): A comparative FESEM & EDS in-vitro study
Authors: Wani Mohsin Aslam , Khattri Shantanu , Hassan Nadeem , Siddiqui Shiraz , Amir Mohd. , Zaffar Saeed 
Published: June 2023

This research work was designed to appraise and equate the remineralizing efficiency of two calcium-based phosphate delivery agents, Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) and Calcium Sucrose Phosphate (CaSP) for preventing the development of White Spot Lesions (WSL) around the orthodontic brackets. Forty orthodontically removed premolar teeth were randomly allocated to Group 1(n=20) - (CPP-ACP) and Group 2(n=20) - (CaSP). All the specimens were subjected to FESEM and EDS analysis before the initial demineralization phase and after 14 days of the pH cycling phase, to observe and record changes in surface topography and mineral content (Ca/P ratio % wt.). Statistical data for the Intragroup comparison were analyzed by using Paired sample t-test, whereas for the Intergroup comparison, an Unpaired t-test was performed. Furthermore, the One-way ANOVA test was applied for comparing Intragroup data and the Post-hoc Tukey test was applied to compare Intergroup data. Group 1 samples showed an 11.3%increase in remineralization and Group 2 samples showed a 21.3%increase in remineralization, indicating a statistically significant (p &#60; 0.05) 11% of greater remineralizing efficiency of CaSP. The use of Calcium Sucrose Phosphate (CaSP) tooth cream around the orthodontic brackets seems to produce significantly better remineralization effects.
MODERN CONCEPTS OF GAMIFICATION IMPLEMENTATION IN THE TRAINING SYSTEM FOR TEACHERS OF THE UKRAINIAN AND ENGLISH LANGUAGES
Authors: Ruskulis LiliÑ–a , Maiboroda Rymma , Rodionova Inna , Gurduz Andriy , Aizikova Lidiia , Mkhytaryan Olha 
Published: June 2023

The article clarifies that for the young people of the Zoom generation who have grown up in the age of the Internet, have unlimited access to any information and since childhood have been using digital technologies, classical higher education cannot provide everyone with necessary competencies and soft-skills by traditional methods. The study has defined that gamification is the introduction of computer games into educational activities, adding game elements to increase visualization, motivation training and, accordingly, the level of mastery of theoretical material, i.e. feedback with a student. It has been proved that gamification helps identify a leader and determine the level of training of an education seeker on this or that question (subject); unite students with a common language literary idea and direct all their efforts to its disclosure and representation; reduce the level of conflicts, andÂ increase effectiveness of the educational process. The following components of the gamified process (user; accumulated points; game levels; ranking of participants; badges), forms (competitive, victorious and aesthetic) and services for introducing gamification into the education system (Alice, Scratch, Studio Code; CodeSchool; MotionMathGames; Mathematics; Spongelab; Kahoot!; Zombie-BasedLearning; MinecraftEdu; World of Classcraft (WoC); WildInternetWoods) have been characterized. The prerequisites for the implementation of the gamification method, to which the level of theoretical training of students, educational content, motivation of students of higher education to perform certain tasks, a level development of mental processes (thinking, perception, memory, attention, imagination and etc.) have been analyzed. The system of tasks, a quality control of which is organized by using games developed with the help of online Wordwall service has been developed and presented. The effectiveness of the implementation of the gamification method into the process of training of future teachers of the Ukrainian and English languages, which convincingly is represented by the diagram has been proved.
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Diyaliz hastalarında sistemik immün inflamasyon indeksi mortaliteyi öngörebilir
Authors: ERCAN Zafer , AYLI Mehmet Deniz 
Published: June 2023

Amaç: Böbrek yetmezliğinde artmış inflamasyon söz konusudur. Serum ferritini bir akut faz reaktanıdır. Sistemik immün inflamasyon indeksi, kardiyovaskuler hastalıklarda ve kanserlerde prognostic önemi olduğu gösterilen, nötrofil, lenfosit ve trombosit sayılarından hesaplanan yeni bir belirteçtir. Bu çalışma, sistemik immün inflamasyon indeksinin diyaliz hastalarının mortalite riskini belirlemede kullanılabilirliğini ve mortalite ile ferritin düzeyleri arasındaki ilişkiyi belirlemeyi amaçlamaktadır.
Gereç ve Yöntemler: Çalışmaya 84 hemodiyaliz ve periton diyaliz hastası alındı. Hastaların bazal demografik, klinik ve laboratuvar verileri, tıbbi kayıtlardan elde edildi. Mutlak nötrofil lenfosit oranının, mutlak platelet ile çarpımı ile sistemik immün inflamasyon indeksi elde edildi.
Sonuç: Hastaların ortalama yaşı 51.3 ± 20.1olup, ortalama takip süreleri 60 (6 ~ 85) aydı. Takip süresince hastaların 45(%53) ü öldü. Hastalar medyan ferritin düzeyine göre analiz edildi. Kaplan-Meier analizine göre ferritinin yüksek olduğu grupta mortalitenin daha yüksek olduğu saptandı (log-rank test, P = 0.029).
Yine hastalar medyan sistemik immün inflamasyon indeksine göre analiz edildi. Kaplan-Meier analizine göre sitemik immün inflamasyon indeksinin yüksek olduğu grupta daha yüksek mortalite oranları saptandı (log-rank test, P = 0.029).
Çok değişkenli regresyon analizinde yaş (HR 1.060, P=0.00), Kt/V (HR 0.161, P=0.014), CRP (HR1.001, P=0.0429) ve Sistemik immün inflamasyon indeksi (HR 1.001, P=0.00) ve ferritin (HR) 1.001, P=0.013) tüm nedenlere bağlı ölümlerin en önemli belirleyicileriydi.
Tartışma: Yeni bir inflamatuar belirteç olan Sistemik immün inflamasyon indeks ve ferritin, diyaliz hastalarında tüm nedenlere bağlı ölümlerle ilişkilidir. Diyaliz hastalarında inflamasyonun Sistemik immün inflamasyon indeks ve ferritin düzeyleri ile takip edilebileceğini düşünüyoruz.
In Silico Analysis of Chalcone Derivatives as Potential Antibacterial Agents against DHPS Enzyme
Authors: Amalina Ilma , Tri Puspaningsing Ni Nyoman , Suwito Hery 
Published: June 2023

Chalcone and its derivatives have been reported to perform as antibacterial agents. With the increasing threat of antibacterial resistance in pharmaceutical sector today, the discovery of new antibacterial agents is essential to accomplish good health and well-being in supporting Sustainable Development Goals (SDGs) point 4. In silico analysis is a method used to evaluate some candidates of active compounds before the synthesis process is conducted. This study aims to investigate three chalcone derivatives as potential antibacterial agents using in silico method of molecular docking. The three chalcone derivatives, 3-(4-methoxyphenyl)1-phenylprop-2-en-1-one (1), 1-(4-aminophenyl)-3-(4- methoxyphenyl) prop-2-en-1-one (2) and 1-(4-bromophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one (3), were designed as pABA competitive inhibitor on DHPS and analyzed against Eschericia coli. This inhibitory mechanism was folate synthesis inhibition as precursor to DNA and RNA synthesis. Molecular docking of three chalcone derivatives with DHPS was generated using Autodock4. The results of this study showed that free energy binding (kcal/mol) of compounds (1), (2) and (3) were -6.27, -5.35 and -5.77, respectively. Besides, the Ki constant for three compounds in order were 25.50 µM, 120.32 µM and 58.84 µM, respectively. In fact, the molecular docking positions illustrated that three chalcone derivatives occupied the active site cleft. Specifically, compound (1) indicated the best outcome among the two other candidates. Meanwhile, sulfadiazine molecular docking as positive control showed lower free binding energy (-0.86 kcal/mol) and Ki constant (233.19 mM) compared to three other candidates. Therefore, three chalcone derivatives analyzed in this study demonstrated a role as potential antibacterial agents.
Authors: Syska Kavadya 
Published: June 2023

Halal menjadi salah satu standar yang wajib dipenuhi untuk memberikan perlindungan terhadap kehalalan suatu produk yang dikonsumsi atau digunakan oleh masyarakat. Sebagai seorang muslim, penting untuk memahami status kehalalan suatu produk yang akan dikonsumsi maupun digunakan. Akan tetapi, tidak semua konsumen memahami status kehalalan produk yang akan dikonsumsi sehingga perlu adanya regulasi untuk mengatur dan memastikan produk yang beredar di masyarakat memiliki status kehalalan yang jelas. Salah satu cara melakukan sertifikasi halal Usaha Mikro dan Kecil adalah dengan halal self declare. Tujuan penelitian ini untuk mengetahui pengetahuan pelaku usaha mikro kecil tentang halal self declare di Simpang GOR Satria Purwokerto. Metode yang digunakan dalam penelitian ini yaitu metode kuantitatif. Data diperoleh dari hasil menyebarkan kuesioner secara langsung, observasi, dan wawancara terhadap pelaku UMK yang terdapat di wilayah Simpang GOR Satria Purwokerto dengan alat bantu kuesioner. Data yang di peroleh menggunakan analisis kuantitatif. analisis data menggunakan analisis deskriptif dan regresi logistik. Data hasil wawancara dianalisis menggunakan software Microsoft excel. Hasil penelitian menunjukkan pengetahuan pelaku usaha mikro kecil di Simpang GOR Satria Purwokerto tinggi. Hasil analisis deskriptif menunjukkan bahwa variabel usia, agama, pedidikan, berpengaruh, pengetahuan halal, networking dan sosialisasi signifikan terhadap tingkat pengetahuan pelaku usaha mikro dan kecil terhadap halal self declare di Pasar Sunday Morning Simpang GOR Satria Purwokerto.
Authors: Ediati Rifah , Siswantoro Siswantoro , Al Hamid , Nur Nadiyatul Fitriyah 
Published: June 2023

Pada buah tomat segar, warna merupakan indikator penting yang menentukan penerimaan konsumen. Teknologi pascapanen banyak ditujukan untuk mempertahankan warna tomat pada rentang jingga ke merah muda. Model untuk memprediksi perubahan warna tomat selama penyimpanan masih sedikit dikaji. Model prediksi ini akan berguna untuk melihat bagaimana perubahan warna secara alami dan bagaimana perubahan warna saat mendapat perlakuan teknologi pasca panen, apakah model perubahan warna masih tetap sama dan hanya berubah nilai konstantanya ataukah modelnya juga mengalami perubahan. Untuk menyelidiki hal tersebut, dalam penelitian ini dilakukan penyimpanan tomat dalam kondisi tanpa perlakuan dan tomat dengan perlakuan ethylene scavenger (ES) dari campuran arang aktif bambu dan KMnO4. Tomat dikemas menggunakan kardus yang sudah ditambahkan ethylene scavenger dengan massa 2 gram, 4 gram, dan 6 gram ES, kemudian disimpan dalam suhu ruang selama 10 hari dan dilakukan pengamatan warna setiap hari. Hasil penerapan model autokatalisis menunjukkan penurunan warna kuning dan kecerahan mengikuti model kinetika orde satu, sedangkan peningkatan warna merah mengikuti model logistik. Perlakuan massa ethylene scavenger yang paling efektif ditunjukkan pada penggunaan 2 gram ethylene scavenger, yang diindikasikasikan oleh nilai k terkecil pada perubahan parameter kecerahan, warna kuning, dan warna merah tomat. Penambahan ethylene scavenger dapat menghambat penurunan kecerahan tomat, kenaikan warna merah tomat, dan penurunan nilai warna kuning tomat selama penyimpanan.
Kata kunci: tomat, arang aktif bambu, KMnO4, ethylene scavenger
CERPEN LESUNG PIPIT KARYA EKA KURNIAWAN: KONSEPSI KEPERAWANAN SEBAGAI STRATEGI PERLAWANAN
Authors: Tarigan Marsten Lihardo , Luhulima Fiona Djunita Natalia , Paradida Yulia Putri 
Published: June 2023

Abstrak
Salah satu konsepsi yang masih dipegang oleh masyarakat sampai pada saat ini adalah mengenai keperawanan. Konsepsi keperawanan ini menjadi isu seksualitas yang seringkali menjadi pembahasan penting dalam masyarakat. Keperawanan seringkali dianggap sebagai standar kesucian dari seorang perempuan. Cerpen Lesung Pipit karya Eka Kurniawan menggambarkan kompleksitas kehidupan perempuan dengan nilai dan konsepsi yang melingkupinya. Karya sastra yang mengetengahkan masalah perempuan dan seksualitas seringkali menunjukkan gambaran perlawanannya terhadap konsepsi yang ada dan ketimpangan yang dialami perempuan. Penelitian ini bertujuan untuk membahas konsepsi keperawanan yang memiliki potensi sebagai bentuk perlawanan terhadap stereotip atau pengukuhan stereotip itu sendiri bagi perempuan melalui tokoh dalam cerpen dengan pendekatan kritik sastra feminis. Hasil dari penelitian ini menunjukkan bentuk penggambaran strategi perlawanan dan konsepsi keperawanan dalam cerpen, tokoh perempuan di dalamnya ingin menyatakan bahwa keperawanan yang dianggap sebagai standar nilai yang melemahkan perempuan, dapat juga dimanfaatkan sebagai kekuatan dan strategi untuk melawan. Selanjutnya, ditemukan juga gambaran pengukuhan terhadap konsepsi keperawanan di dalam cerpen. Nilai-nilai standar yang dilekatkan pada perempuan tidak hanya dimiliki dan diyakini oleh laki-laki tetapi juga perempuan.
Kata kunci: konsepsi keperawanan, strategi, feminisme
Authors: Fadillah Ririn Ariyanti , Aulia Hanindya Restu 
Published: June 2023

Pembelajaran menulis teks biografi kelas X SMA Negeri 1 Wiradesa belum terlaksana dengan baik karena siswa tidak terlalu berminat dalam menulis sehingga membutuhkan metode yang tidak membosankan. Untuk meningkatkan keterampilan menulis teks biografi siswa kelas X SMA Negeri 1 Wiradesa digunakan metode bimbingan langsung. Penelitian dilakukan dalam dua siklus. Setiap siklus meliputi perencanaan, tindakan, observasi dan refleksi. Hasil penelitian ini menunjukkan adanya proses pembelajaran dan perbaikan. Hal ini terlihat pada nilai pra siklus sebesar 72,94, rata-rata siklus I sebesar 87,22 dan siklus II sebesar 90,77. Perubahan perilaku juga berubah menjadi lebih baik.
Kata kunci: menulis; teks biografi; dan metode bimbingan langsung
Combinatorial enzymatic catalysis for bioproduction of ginsenoside Compound K
Authors: Yang Wenhua , Zhou Jianli , Gu Qiuya , Harindintwali Jean , Yu Xiaobin , Liu Xiaobo 
Published: June 2023

Abstract

Enzymatic catalysis provides a clean, efficient, and stable solution for the industrial preparation of Ginsenoside Compound K (CK). However, exploring high-efficiency enzymes and establishing catalytic processes remain challenging. Here, we reportAspergillus tubingensisJE0609 with the ability to efficiently transform protopanaxadiol-type ginsenosides into CK. Our transcriptome analysis and peptide mass fingerprinting reveal that three ginsenoside hydrolases BG07, BG19, and BG23 are present in JE0609. Notably, BG23 is highly expressed inPichia pastoriswith a yield of 235.73 U/mL (pNPG), with a broad adaptation to acidic (pH 4.5 to 7.0) and thermophilic (temperature < 50 °C) conditions. Inspired by the above outcomes, we establish a one-pot combinatorial enzyme-catalyzed strategy for conversion of Rb1, Rb2, Rb3, and Rc into CK, with a yield of 396.7 mg·L-1·h-1, which is the highest one by now. We argue that this combinatorial enzymatic catalysis strategy opens the probability of bioproduction of CK and other ginsenosides.
Screening for hypertension in adults: protocol for evidence reviews to inform a Canadian Task Force on Preventive Health Care guideline update
Authors: Shaver Nicole , Beck Andrew , Bennett Alexandria , Wilson Brenda J. , Garritty Chantelle , Subnath Melissa , Grad Roland , Persaud Navindra , Thériault Guylène , Flemming Jennifer , Thombs Brett D. , LeBlanc John , Kaczorowski Janusz , Liu Peter , Clark Christopher E. , Traversy Gregory , Graham Eva , Feber Janusz , Leenen Frans H. H. , Premji Kamila , Pap Robert , Skidmore Becky , Brouwers Melissa , Moher David , Little Julian 
Published: June 2023

Abstract
Purpose: To inform updated recommendations by the Canadian Task Force on Preventive Health Care on screening in a primary care setting for hypertension in adults aged 18 years and older. This protocol outlines the scope and methods for a series of systematic reviews and one overview of reviews.
Methods: To evaluate the benefits and harms of screening for hypertension, the Task Force will rely on the relevant key questions from the 2021 United States Preventive Services Task Force systematic review. In addition, a series of reviews will be conducted to identify, appraise, and synthesize the evidence on (1) the association of blood pressure measurement methods and future cardiovascular (CVD)-related outcomes, (2) thresholds for discussions of treatment initiation, and (3) patient acceptability of hypertension screening methods. For the review of blood pressure measurement methods and future CVD-related outcomes, we will perform a de novo review and search MEDLINE, Embase, CENTRAL and APA PsycInfo for randomized controlled trials, prospective or retrospective cohort studies, nested case control studies, and within-arm analyses of intervention studies. For the thresholds for discussions of treatment initiation review, we will perform an overview of reviews and update results from a relevant 2019 UK NICE review. We will search MEDLINE, Embase, APA PsycInfo and Epistemonikos for systematic reviews. For the acceptability review, we will perform a de novo systematic review and search MEDLINE, Embase, and APA PsycInfo for randomized controlled trials, controlled clinical trials, and observational studies with comparison groups.Websites of relevant organizations, grey literature sources, and the reference lists of included studies and reviews will be hand-searched. Title and abstract screening will be completed by two independent reviewers. Full-text screening, data extraction, risk of bias assessment, and GRADE (Grading of Recommendations Assessment, Development and Evaluation) will be completed independently by two reviewers. Results from included studies will be synthesized narratively and pooled via meta-analysis when appropriate. The GRADE approach will be used to assess the certainty of evidence for outcomes.
Discussion: The results of the evidence reviews will be used to inform Canadian recommendations on screening for hypertension in adults aged 18 years and older.
Systematic review registration: This protocol is registered on PROSPERO (to be registered following TF approval) and is available on the Open Science Framework (osf.io/8w4tz).
A comparative study of the efficacy of different doses of platelet-rich plasma in the treatment of Degree I and Degree II knee meniscus injury in young adults: Study protocol for a prospective, single-center, three-blind, randomized controlled trial
Authors: Cheng Chao , Liu Jiancheng , Pang Rizhao , Wang Zhengdong , Xiao Zhonglin , Zheng Jinqi , Li Jiayu , Wang Linjie , Zhang Xin , Ma Xin , Gou Xiang , He Xin , Bai Ling , Wang Wenchun 
Published: June 2023

Abstract

Background:
Grade I and II knee meniscus injuries in young people account for a relatively large proportion of sports injuries. If not cured in time, it may seriously affect the quality of life and even cause disability.Studies have shown that platelet-rich plasma (PRP) is effective in the treatment of knee meniscus injury, but the optimal therapeutic dose of PRP has not been regulated and clarified in current relevant guidelines or expert consensus.This study intends to use a randomized controlled trial to compare and analyze the efficacy and safety of 2ml, 5ml and 8ml PRP in the treatment of meniscus injury of knee joint, so as to provide evidence-based medical evidence for improving the clinical guidelines for the treatment of meniscus injury with PRP.
Methods/design:
This study is a one-year prospective single-center triple-blind randomized controlled trial. Patients who meet the inclusion criteria are randomly divided into the experimental group and the control group. The experimental group is set as the PRP treatment group, and the control group is set as the placebo group. The treatment of all patients will last for 5 weeks and follow-up for 6 months.The experimental group and the control group plan to evaluate Lysholm knee score, MRI (including T2mapping technology) and other main observation indicators.And visual analog scale (Visual analogue scale, VAS), quality of life score(36-item Short Form Health Survey, SF-36), muscle Bone ultrasound, infrared thermal imaging,incidence of adverse reactions and other secondary observation indicators are used to compare the curative effects.All these results will be analyzed at the end of the trial Analysis.
Discussion:
There is no uniform standard for the dose of PRP in the treatment of meniscus injury, and there is no literature report on whether there are differences in efficacy and safety among several commonly used doses in clinical practice. This study explores the clinical appropriate dose of PRP in the treatment of meniscus injury of knee joint of young people in degree I and II,which provides a scientific basis for the optimization of the treatment of meniscus injury, and provides evidence-based medical evidence for the revision and improvement of PRP treatment guidelines for meniscus injury.
Trial Registration: China Clinical Trial Registration: ChiCTR2200057591, November 14,2022
Experimental Ethics: 2022EC1-008
The interplay between suicidal experiences, psychotic experiences and interpersonal relationships: a qualitative study
Authors: Gooding Patricia , Haddock Gillian , Harris Kamelia , Asriah Menita , Awenat Yvonne , Cook Leanne , Richard Drake , Emsley Richard , Huggett Charlotte , Jones Steven , Lobban Fiona , Marshall Paul , Pratt Daniel , Peters Sarah 
Published: June 2023

Abstract
Background Suicidal thoughts, acts, plans and deaths are considerably more prevalent in people with non-affective psychosis, including schizophrenia, compared to the general population. Social isolation and interpersonal difficulties have been implicated in pathways which underpin suicidal experiences in people with severe mental health problems. However, the interactions between psychotic experiences, such as hallucinations and paranoia, suicidal experiences, and the presence, and indeed, absence of interpersonal relationships is poorly understood and insufficiently explored. The current study sought to contribute to this understanding.Methods An inductive thematic analysis was conducted on transcripts of twenty-two, individual, semi-structured interviews with adult participants who had both non-affective psychosis and recent suicidal experiences. A purposive sampling strategy was used. Trustworthiness of the analysis was assured with researcher triangulation.Results Participants relayed both positive and negative experiences of interpersonal relationships. A novel conceptual model is presented reflecting a highly complex interplay between a range of different suicidal experiences, psychosis, and aspects of interpersonal relationships. Three themes fed into this interplay, depicting dynamics between perceptions of i. not mattering and mattering, ii. becoming disconnected from other people, and iii. constraints versus freedom associated with sharing suicidal and psychotic experiences with others.Conclusion This study revealed a detailed insight into ways in which interpersonal relationships are perceived to interact with psychotic and suicidal experiences in ways that can be both beneficial and challenging. This is important from scientific and clinical perspectives for understanding the complex pathways involved in suicidal experiences.Trial registration ClinicalTrials.gov (NCT03114917), 14th April 2017. ISRCTN (reference ISRCTN17776666 https://doi.org/10.1186/ISRCTN17776666); 5th June 2017). Registration was recorded prior to participant recruitment commencing.Trial registration ClinicalTrials.gov (NCT03114917), 14th April 2017 (14-04-2017). ISRCTN (reference ISRCTN17776666 https://doi.org/10.1186/ISRCTN17776666); 5th June 2017). Registration was recorded prior to participant recruitment commencing.