bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft Biometrics for Authentication and Identification Hand Based on the Use of the Keyboard
Authors: Alotoum Y.M. A.A. , Krasov A. V. 
Published: January 2025

Relevance. Nowadays, technological systems, artificial intelligence, the general availability of the Internet and penetration into the systems of banks, institutions and social networks have become a studied science and are accessible to all groups and ages. One of the main tasks was to provide a system for protecting confidential information from hackers, as well as easy access to authentication and identification of users. Biometric systems came to the fore, including mouse movement dynamics and keystroke dynamics, which reveal the typing style and mouse movement of each person. Soft biometrics is an interesting and inexpensive biometric method that does not require additional equipment. The system identifies a person based on the input information they enter in a special column. Hand identification dynamics falls into the category of behavioral soft biometrics, that is, the user's patterns reflect the individual program of actions that he follows when using the site.The goal of this article the purpose of this work is to improve the security level by creating a function that will strengthen the authentication system and improve the iron gate Методы исследования. In carrying out the work, methods of analysis and synthesis, theories of algorithms, laws of kinematics, neural networks, keystroke dynamics and soft biometrics were used.Results. A method for extracting dynamic characteristics of keystrokes is described. A neural network is created and a threshold value is determined for identifying the type of typing hand.Scientific novelty. Unlike known authentication methods, the proposed method is used to determine the typing hand on the keyboard through a neural network using the laws of kinematics, soft biometrics and extracting the dynamics of keystrokes in order to determine the value and accuracy of determining the type of typing hand.Significance. The proposed solution allows to increase the security of user authentication, increase the speed of implementation and reduce the cost. The results obtained in the work are positive and can be used in the near future. In turn, soft biometric measurements depend on human behavioral patterns, which complicates user falsification. It is difficult to imitate typing behavior, since it is ballistic (semi-autonomous), which makes behavioral information valuable as a soft and sensitive biometric method.
The Resampling Methods Direct Sequence Spread Spectrum Signal’s Demodulator Implementation
Authors: Brusin E. A. 
Published: January 2025

Relevance. The direct spread spectrum signals are widely used in navigation and communication systems recently. These signals prevail in modern satellite navigation systems and are used in various communication systems with code division multiplexing in particularly. In this regard, the tasks of building direct spread spectrum signals’ demodulators have the key importance. Mach importance in the construction of demodulators is the problem chip rate variability.The purpose of the study is to propose a demodulator structure focused on solving this problem.Methods. The research is based on computer modeling methods.Decision. The paper proposes an approach to the construction of the direct spread spectrum signal’s demodulators based on modern methods of digital signal processing. It is shown that the main advantage of the proposed approach is the possibility of rebuilding the variable chip rate demodulators. Based on the results obtained, a scheme for the direct spread spectrum signals demodulator using resampling methods is proposed. Resampling, in turn, is implemented on the basis of polynomial interpolation using Lagrange polynomials. The structure of the resampler is proposed, similar to the structure of an interpolating filter with a finite impulse response. The presented simulation results show the effectiveness of the proposed approach.Novelty. It seems that the currently common methods of implementing direct spread spectrum signal in terms of delay synchronization do not sufficiently meet modern requirements. The implementation of delay synchronization schemes based on resampling is practically not discussed in well-known works. At the same time, modern methods and devices of digital signal processing make it possible to ensure an effective hardware implementation of the scheme in question. In this context, the approach proposed in the paper to the construction of demodulators seems to be very relevant.Significance. The results of the work can be used in the construction with direct spread spectrum signals’ demodulators for a wide range of communication and navigation systems. The synchronous sampling structure proposed in this paper is very promising, especially for variable chip rate demodulators.
Sensory characteristics of fat-and-oil products obtained from different grape cultivars
Authors: Kotliar Ye. , Iegorov B. , Levchuk I. 
Published: January 2025

Fat-and oil products were obtained from different grape cultivars with the use of the extra virgin technology. The object of analysis was a number of grape cultivars, sources of raw materials for fat-and-oil products from grape seeds. It was found promising to study the seeds of the following grape varieties (harvested in 2019, 2020, and 2021): Lydia, Isabella, Moldova, Baco, Odesa Black, Cabernet, and of the following blends: No. 1 – Muscat Blanc + Noah (50:50), No. 2 – Riesling + Chardonnay (50:50), and No. 3 – Chardonnay + Sukholimansky (50:50). These cultivars are the ones most commonly used in the winemaking and canning industries. From the above samples, such fat-and-oil products were obtained as oil and oilcake, which underwent sensory investigation. The sensory evaluation results for the oils from various grape cultivars were as follows. For those harvested in 2019, the highest sensory score was that of Odesa Black (5.0) and Cabernet (5.0), the lowest – of blends No. 2 and No. 3 (4.9). For those harvested in 2020, the highest sensory score was that of Moldova and Odesa Black (5.0), the lowest – of Lydia (all parameters 4.9, clarity 4.8). For those harvested in 2021, the highest sensory score was that of Odesa Black (5.0), the lowest – of blend No. 1 (all parameters 4.7). The sensory evaluation results for the oilcake from grape seeds were as follows. For the seeds of grapes harvested in 2019, the highest sensory score was that of Odesa Black (5.0), the lowest – of blend No. 3 (4.7). For those harvested in 2020, the highest sensory score was that of Moldova and Odesa Black (5.0), the lowest – of Lydia (all parameters 4.9, clarity 4.8). For those harvested in 2021, Odesa Black was graded the highest (5.0), and blend No. 1 the lowest (all parameters 4.7). It is worth pointing out that the results for all fat-and-oil products (oilcake and oil) from seeds of different grape cultivars harvested in 2019–2021 were almost equally excellent by a complex of sensory parameters. However, those for Odesa Black and Cabernet were the highest.
Laporan Kasus: Plantar Fascitis Disertai Obesitas dengan Komsumsi Rebusan Herbal Jahe, Sereh dan Kunyit
Authors: Rianti Riska , Makmun Armanto 
Published: January 2025

Plantar Fascitis adalah suatu inflamasi yang terjadi pada plantar fascia akibat iritasi degeneratif pada fascia plantar dimana kondisi ini bisa terjadi karena trauma atau penyebab multifaktoral lainnya dimana salah satunya adalah obesitas. Peningkatan massa tubuh dapat menyebabkan peningkatan tekanan pada ligamen-ligamen dan otot kaki pada saat menahan berat tubuh yang pada akhirnya menyebabkan mikrotrauma. Untuk penanganan pada plantar fascitis berupa terapi farmakologi dan non-farmakologi dalam menurunkan intensitas nyeri yaitu dengan menggunakan terapi herbal dengan tanaman-tanaman yang dapat digunakan sebagai pengobatan alternatif. Saat ini terdapat berbagai tanaman yang dapat dimanfaatkan untuk pengobatan alternatif diantaranya adalah jahe, sereh dan kunyit. Jurnal ini bertujuan untuk membahas terkait laporan kasus dengan komsumsi rebusan herbal jahe, sereh dan kunyit sebagai analgesik pada pasien plantar fascitis. Berdasarkan beberapa literatur didapatkan bahwa jehe mepunyai sifat panas, pahit serta aromatic dari oleoresin, gingenol, shagaol serta zingeron yang memiliki kemampuan sebagai anti-inflamasi dan analgesik. Pada Sereh dan kunyit terdapat minyak astiri yang bersifat kimiawi dan memiliki efek farmakologi sebagai anti-inflamasi dan analgesik. Kesimpulan yang didapatkan pada laporan kasus ini dimana pemberian terapi farmakologis dan dikombinasikan dengan terapi non farmakologis berupa peregangan dan pemberian tanaman herbal dengan rebusan jahe, sereh dan kunyit membuahkan hasil dalam mengurangi intensitas nyeri yang dialami pasien.
Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors
Authors: Ahmed Alshimaa A. Y. , Mohammed Anber F. , Almarhoon Zainab M. , Bräse Stefan , Youssif Bahaa G. M. 
Published: January 2025

IntroductionThis work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway.MethodsThe research assesses the antiproliferative efficacy of compounds 6a-i and 10a-i against various cancer cell lines.Results and DiscussionThe research emphasizing hybrids 6i and 10e for their remarkable activity, with GI50 values of 29 nM and 25 nM, respectively. The inhibitory effects of the most potent hybrids 6e, 6i, 10d, 10e, and 10g on EGFR were assessed. Compounds 6i and 10e exhibited greater potency than erlotinib as EGFR inhibitors. Compounds 6i and 10e were also examined for their apoptotic potential, revealing that these compounds promote apoptosis by activating caspase-3, caspase-8, and Bax, while down-regulating the anti-apoptotic protein Bcl-2. Molecular docking experiments are thoroughly examined to validate the binding interactions of the most active hybrids, 6i and 10e, with the EGFR active site. Furthermore, our new study examined the ADME properties of the new hybrids.
Danshen injection ameliorates unilateral ureteral obstruction-induced renal fibrosis by inhibiting ferroptosis via activating SIRT1/GPX4 pathway
Authors: Cao Yiwen , Zhao Huan , Lin Shuyin , Chen Junqi , Xiong Jingli , Zeng Zhijun , Long Ziyu , Su Yingru , Zhong Yingqi , Zhao Lingru , Zhang Mingshan , Wu Junbiao , Zhou Yuan , Zhou Jiuyao 
Published: January 2025

IntroductionThe pathogenesis of renal fibrosis is related to blood stasis, and the method of promoting blood circulation and removing blood stasis is often used as the treatment principle. Danshen injection (DSI) is a commonly used drug for promoting blood circulation and removing blood stasis in clinic. However, whether DSI slows the progression of renal fibrosis or the potential mechanism is uncertain.MethodsWe investigated renal fibrosis models using UUO mice and TGF-β stimulation in HK-2 cells.ResultsOur findings revealed that DSI or Fer-1 alleviated kidney injury by ameliorating renal morphology injury and pathological injury in vivo. Besides, DSI or Fer-1 inhibited renal fibrosis in vivo and in TGF-β-induced HK-2 cells. Furthermore, ferroptosis was lessened under DSI or Fer-1 treatment. More importantly, the DSI active ingredients (danshensu, salvianolic acid B, protocatechuic aldehyde, caffeic acid and tanshinone IIA) could bind to SIRT1. The protein levels of SIRT1 and GPX4 were downregulated accompanied by the incremental concentrations of TGF-β or Erastin, which were repaired by DSI or Fer-1 intervention. However, the inhibition of ferroptosis and renal fibrosis owing to DSI were reversed by SIRT1 inhibitor EX527.ConclusionTaken together, our results indicated that DSI could protect against ferroptosis to attenuate renal fibrosis by activating the SIRT1/GPX4 pathway. It is expected to be a potential agent to treat renal fibrosis.
Mental health risk in human services work across Europe: the predictive role of employment in various sectors
Authors: Győri Ágnes , Perpék Éva , Ádám Szilvia 
Published: January 2025

BackgroundHuman services occupations are highly exposed to mental health risks, thus psychosocial risk management is critical to assure healthy and safe working conditions, promote mental health and commitment, and prevent fluctuation of employees. However, still little is known about prominent psychosocial risk factors in various human services work.ObjectivesTo identify prominent psychosocial risk factors of mental health in human services occupations and to explore their individual and organizational correlates in 19 European countries.MethodsCross-sectional survey using data from the European Union's Labor Force Survey among 379,759 active employees in 19 European countries. First, a descriptive analysis was carried out to establish the prevalence of mental health risk factors. Then sociodemographic correlates of occupational mental health risk factors were assessed by means of Pearson's chi-squared test. Finally, correlations were explored between perceived psychosocial risk factors and human vs. non-human services occupations, as well as contextual variables by applying multilevel logistic and multinomial regression analyses.ResultsThe prevalence of mental health risk was 45.1%. Work overload (19.9%), dealing with difficult clients (10.2%), and job insecurity (5.8%) were the most prevalent mental health risk factors among European employees. We identified significant differences in the prevalence of mental health risks and specific mental health risk factors among employees according to sex, age, and educational attainment. The prevalence of mental health risks was significantly higher among women (47.0%, man: 43.3%), workers aged 35–50 years (47.5%, &gt;50: 44.4%, &lt;35: 42.3%), and those with the higher level of education (51.9%, secondary with diploma: 42.6%, elementary: 36.2%). Employees working in healthcare in Northern Europe were most likely to be exposed to mental health risks (AME = 0.717). Working in healthcare in Northern Europe was the strongest predictor of reporting work overload (AME = 0.381). Working in social care in Central and Eastern Europe was the strongest predictor of reporting dealing with difficult clients (AME = 0.303) as the most prevalent mental health risk factor.ConclusionUnderstanding the impact of employment in specific human services occupations on mental health and its specific occupational stressors are vital to improve mental health and safety at work and maintain high quality services.
Association between sedentary behavior, physical activity, and osteoarthritis: results from NHANES 2007–2020 and Mendelian randomization analysis
Authors: He Jiangqin , Zhang Cao , Yang Lili 
Published: January 2025

IntroductionOsteoarthritis (OA) is a prevalent and debilitating disorder that affects the joints and has a complex array of causes. While sedentary behavior (SB) and physical activity (PA) have been implicated in OA risk, the relationship between these factors and OA development remains unclear. This study investigates the correlation and potential causality between SB, PA, and OA using both cross-sectional and Mendelian randomization (MR) analysis.MethodsWe conducted a two-phase study that included a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) and a MR analysis. A weighted analysis was performed on data from the NHANES to explore the relationship between SB, PA, and the risk of OA. Logistic regression was used to assess the association between SB, PA, and OA, adjusting for potential confounders. Non-parametric curve fitting was applied to examine the dose-response relationship between PA levels and OA onset. Additionally, MR was utilized to infer the genetic causality between SB, PA, and OA risk, using genetic instruments as proxies for SB and PA.ResultsThe final analysis, which included 24,738 participants, revealed that OA prevalence was 13.47%, with individuals diagnosed with OA exhibiting significantly higher levels of SB and lower levels of PA. A U-shaped relationship was observed between PA and OA risk, with a decrease in OA incidence as PA levels increased, although the protective effect of PA was less pronounced in individuals with severe SB. MR analysis indicated that genetically inferred SB was associated with a higher likelihood of OA (IVW OR 1.20, 95% CI 1.13–1.28), while increased PA was inversely associated with OA risk (IVW OR 0.85, 95% CI 0.73–0.98).ConclusionThis research emphasizes the significance of SB and PA as modifiable factors influencing the risk of OA. It is recommended that individuals at risk of OA should aim to participate in regular physical activity and minimize sedentary behavior to lower their risk of developing the disease. The MR analysis results support the potential causal impact of SB and PA on OA, providing valuable information for the development of therapeutic and rehabilitative strategies.
Joint exploration of network pharmacology and metabolomics on the effects of traditional Chinese medicine compounds in weaned yaks
Authors: Lu Sijia , Zhu Yanbin , Zhang Xiaojuan , Cidan Yangji , Basang Wangdui , Li Kun 
Published: January 2025

IntroductionChinese herbal medicines are relatively inexpensive and have fewer side effects, making them an effective option for improving health and treating diseases. As a result, they have gained more attention in recent years. The weaning period is a critical stage in the life of yaks, often inducing stress in calves. Weaning stress, along with dietary changes, can lead to a decline in physical fitness and immune function, making yaks more susceptible to diarrhea and resulting in high mortality rates during this period. Therefore, our study aimed to address this issue by incorporating traditional Chinese medicine (TCM) formulas into the diet of yaks during the weaning period.MethodsFollowing a dialectical analysis, three TCM formulas, mainly composed of Paeonia lactiflora, Coptis chinensis, and Dandelion, were identified for their anti-inflammatory, antioxidant, and immune enhancing potentials. We explored the possible molecular mechanisms of these TCM formulas using network pharmacology analysis and investigated their effects on the physiology of yaks through metabolomics.ResultsNetwork pharmacology analysis revealed several key target proteins in the protein–protein interaction (PPI) network between three formulas and immune-related genes, including PIK3R1, PIK3CA, JAK2, PTK2, and PYPN11. The key target proteins in the PPI network associated with metabolism-related genes included ENPP1, CYP1A1, PTGS1, members of the CYP1 family, and EPHX2. GO analysis of co-targets revealed highly enriched pathways such as protein phosphorylation, plasma membrane, and one-carbon metabolic processes. Metabolomics revealed significant changes in the abundance of metabolites including dimethyl sulfoxide, tyrphostin A25, and thromboxane A2 in the intestines of weaned yaks supplemented with these Chinese herbal compounds. Significant changes were also observed in pathways such as vitamin A metabolism, chloroalkane, and chloroalkene degradation.DiscussionBased on these findings, it can be inferred that TCM formulas improve the physical fitness of weaned yaks by enhancing antioxidant capacity, boosting immunity, and reducing intestinal inflammation. This study preliminarily elucidates the pharmacological mechanisms by which TCM formulas prevent diarrhea and improve physical fitness in weaned yaks through metabolomics and network pharmacology, paving the way for further evaluation of the effectiveness of these three formulas.
The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation
Authors: Sanatkar S. A. , Kinoshita K. , Maenaka A. , Hara H. , Cooper D. K. C. 
Published: January 2025

An overview is provided of the evolution of strategies towards xenotransplantation during the past almost 40 years, focusing on advances in gene-editing of the organ-source pigs, pre-transplant treatment of the recipient, immunosuppressive protocols, and adjunctive therapy. Despite initial challenges, including hyperacute rejection resulting from natural (preformed) antibody binding and complement activation, significant progress has been made through gene editing of the organ-source pigs and refinement of immunosuppressive regimens. Major steps were the identification and deletion of expression of the three known glycan xenoantigens on pig vascular endothelial cells, the transgenic expression of human “protective” proteins, e.g., complement-regulatory, coagulation-regulatory, and anti-inflammatory proteins, and the administration of an immunosuppressive regimen based on blockade of the CD40/CD154 T cell co-stimulation pathway. Efforts to address systemic inflammation followed. The synergy between gene editing and judicious immunomodulation appears to largely prevent graft rejection and is associated with a relatively good safety profile. Though there remains an incidence of severe or persistent proteinuria (nephrotic syndrome) in a minority of cases. This progress offers renewed hope for patients in need of life-saving organ transplants.
Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis
Authors: Meléndez-Oliva Erika , Martínez-Pozas Oliver , Sinatti Pierluigi , Martín Carreras-Presas Carmen , Cuenca-Zaldívar Juan Nicolás , Turroni Silvia , Sánchez Romero Eleuterio A. 
Published: January 2025

Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function. Initially regarded as a “wear and tear” condition associated with aging and mechanical stress, OA is now recognized as a multifaceted disease influenced by systemic factors such as metabolic syndrome, obesity, and chronic low-grade inflammation. Recent studies have focused on the gut-joint axis to investigate how the gut microbiome modulates inflammation and pain in OA. Materials and Methods: A systematic review was conducted following the PRISMA guidelines and was registered with PROSPERO (CRD42024556265). This review included studies involving adults with symptomatic OA and analyzed the relationship between the gut microbiome and OA-related pain. Randomized and non-randomized clinical trials, case reports, editorials, and pilot studies were excluded. Searches were performed in PubMed, Cochrane Library, and Web of Science without publication date restrictions, and filtered for “observational studies”. The study selection and data extraction were performed by two independent researchers, and the risk of bias was assessed using appropriate tools. Results: Five observational studies were included in the systematic review, and three were included in the meta-analysis. Two studies reported an association between different tryptophan metabolites and pain levels in patients with OA. Two other studies demonstrated a correlation between lipopolysaccharide levels and pain in OA. A fifth study confirmed the relationship between Streptococcus relative abundance of Streptococcus spp. and knee pain. These results were not supported by a meta-analysis, which found no significant association between the presence of pain in OA and the presence of bacilli of the genus Streptococcus or plasma markers of the tryptophan pathway. Conclusions: Current evidence indicates a potential link between gut microbiome dysbiosis and OA-related pain. However, methodological limitations preclude definitive conclusions. Further research using advanced techniques and larger cohorts is needed to validate and extend these findings and elucidate the underlying mechanisms. Targeted manipulation of the gut microbiome may be a valuable strategy for pain management in OA patients.