bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bread‐making properties of different pulse flours in composites with refined wheat flour
Authors: Nkurikiye Eric , Xiao Ruoshi , Tilley Michael , Siliveru Kaliramesh , Li Yonghui 
Published: February 2023

AbstractThere has been a growing demand for pulses due to the nutrition, health benefits, and agronomical advantages, along with the recommendation of international organizations to diversify the use of pulses. Lentil, yellow pea, and chickpea were studied for their effect on the quality of the bread when incorporated into refined wheat flour. The pulse grains were roller milled into different particle sizes (small: 44–59 μm, medium: 70–85 μm, and large: 95–104 μm) with similar composition, and each refined pulse flour was incorporated in refined wheat flour at levels of 5, 12.5, and 20% (wt/wt). The flours were characterized for particle size distribution, starch damage, proximate composition, water retention, and dough mixing properties, followed by baking test and texture analysis. The particle size of the pulse flours did not significantly affect the bread volume or the texture, while increasing the pulse flour incorporation decreased the bread specific volume from 5.0 to 3.4 cm3/g and the hardness of the bread increased from 3.9 to 9.9 N at the maximum incorporation level. The crust color darkened as pulse flour incorporation was increased, while the effect on crumb color was marginable. Among the three pulses, chickpea performed better compared to lentil and yellow pea, and yellow pea resulted in bread with lower volume at all levels of incorporation. Enriched bread can be produced by incorporating pulse flours at up to 12.5% (wt/wt) without significant effect on the quality of bread, with chickpeas possessing better baking properties than yellow pea or lentil.
Plasma disposition of florfenicol after intramuscular administration in rabbits pretreated with pentoxifylline
Authors: Cazanga Victoria , Palma Cristina , Casanova Tomás , Barrera Karin , Valenzuela Cristhian , Acevedo Aracely , Pérez‐Fernández Rubén 
Published: February 2023

AbstractThis work aimed to assess the effects of the coadministration of pentoxifylline (PTX) on the pharmacokinetic profile of florfenicol (FFC) after intramuscular administration in rabbits. Ten New Zealand white rabbits, 1 year of age and 3.9 ± 0.1 kg body weight, were assigned according to a randomized block design to Group 1 (FFC): treated with 30 mg/kg of FFC intramuscularly, and Group 2 (PTX + FFC) treated with an oral dose of 30 mg/kg PTX 45 min before the intramuscular injection of 30 mg/kg FFC. Blood samples were collected before and at different times between 0.5 and 12.0 h after drug administration. FFC plasma concentrations were determined by high‐performance liquid chromatography. Results showed that IM injection of the long‐acting formulation of FFC in rabbits resulted in a slow increase in mean plasma concentrations reaching a Cmax of 3.09 ± 0.52 ug/mL at 2.8 ± 0.45 h (Tmax) after drug administration. While coadministration of PTX and FFC decreased the time to achieve the maximal concentration by modifying the absorption of FFC without changes in the other pharmacokinetic parameters.
Local roots, global vines: Human rights museums in western Japan as expressions of identity
Authors: Mueller Lisa 
Published: February 2023

AbstractRecently human rights movements among Japan's Buraku people have become increasingly globalized, situating the Buraku struggle among those of other caste‐based minorities around the world. Scholars have theorized that this globalization manifests in a global–local feedback loop in which decisions made by global and local actors inform one another. In this study, I utilize field research and qualitative content analysis of brochures at three Buraku human rights museums in western Japan to investigate this global reorientation. I show that two museums correspond to global–local feedback loop theory and I further identify how local nuances affect the disparate strategies the museums employ to engage with this new globalized Buraku identity. The third museum, however, serves as a counterexample by electing to keep its exhibits locally focused, reflecting its community‐driven mission. I argue that these museums function as interlocutors of Buraku identity at both the local and global levels.
Onychomycosis associated with diabetic foot syndrome: A systematic review
Authors: Navarro‐Pérez David , Tardáguila‐García Aroa , García‐Oreja Sara , López‐Moral Mateo , García‐Madrid Marta , Lázaro‐Martínez José Luis 
Published: February 2023

AbstractBackgroundA systematic review was conducted to investigate the prevalence of onychomycosis in patients with diabetes. The association of onychomycosis with risk factors in patients with diabetic foot syndrome was also examined.MethodsThe recommendations in the preferred reporting items for systematic reviews and meta‐analysis (PRISMA) checklist were applied, and the included studies were assessed using the Strengthening the Reporting of Observational studies in Epidemiology (STROBE) method. Searches were conducted in October 2022 using PubMed (Medline) and Scopus for clinical studies, clinical trials, comparative studies, observational studies, and randomised clinical trials or controlled clinical trials addressing the prevalence and consequences of onychomycosis in patients with diabetes, diagnoses or treatments. Two authors performed the study selection and data extraction, and any discrepancies between the two reviewers were resolved through discussion with a third reviewer.ResultsThe systematic review included ten studies that met the inclusion criteria, and these studies enrolled 5664 patients with diabetes. Among these patients, 29.18% had onychomycosis that was mainly caused byTrichophyton rubrum. A significant association was found between the occurrence of onychomycosis and the presence of diabetic neuropathy (p = .012) and elevated glycosylated haemoglobin values (p = .039). There was no significant association between onychomycosis and ulceration (p = .185). Eight studies had a grade 4 level of evidence and a grade C recommendation, and one study had a grade 1b level of evidence and a grade A recommendation.ConclusionThe information described in the literature is insufficient and heterogeneous regarding the association of risk factors and ulceration in patients with diabetic foot compared with developing onychomycosis. There is also a need to implement onychomycosis diagnostic testing instead of relying only on a clinical diagnosis. Additional prospective, randomised, comparative studies are needed to increase the quality of studies in the literature.
Oral complications in a paediatric graft versus host disease (GVHD) clinic: A retrospective study
Authors: Emperumal Chitra Priya , Weller Brett , Okane Sara , Joseph Renita , Kharbanda Sandhya , Ling Zhan , Villa Alessandro 
Published: February 2023

AbstractObjectiveThe aim of this study was to investigate the oral health status among allogeneic transplant recipients who were seen in a multidisciplinary graft‐versus‐host disease paediatric clinic at the University of California, San Francisco (UCSF).MethodsThis was a retrospective cohort study of patients who underwent allogeneic transplants and were seen in the graft‐versus‐host disease paediatric clinic between January 2010 and September 2021. Demographic, medical and oral health data were recorded and analysed using descriptive statistics.ResultsA total of 25 patients were seen in the paediatric graft‐versus‐host disease clinic (68% males) with a median age of 12 years at the time of transplant were included. Among them, 12 patients (48%) were diagnosed with oral chronic GVHD, 11 (44%) with dry mouth, four (16%) with oral pseudomembranous candidiasis, one (4%) with recrudescent Herpes Simplex Virus (HSV) infection and one (4%) with mammalian target of rapamycin‐inhibitor stomatitis and were managed by the oral medicine team, accordingly with medications, such as topical steroids (44%) and anti‐fungal (20%).ConclusionsHSCT recipients may present with a variety of oral complications. Patients may benefit by a multi‐disciplinary approach including a dental specialist as part of the cancer care team.
Endoscopic Revision for Long‐Term Symptomatic Cage Retropulsion after TLIF: The Clinical Presentation in a Single Center
Authors: Xu Guangming , Zhu Guangye , Jiang Xiaobing , Cui Jianchao , Liang Ziyang 
Published: February 2023

BackgroundCage retropulsion after transforaminal lumbar interbody fusion (TLIF) is a common complication that is more frequently detected in the early postoperative period. Revision in the early stages is relatively less difficult in symptomatic cases. However, cage retropulsion is quite rare for patients with intervertebral osseous fusion in the long term after TLIF, and there are no relevant reports related to the revision plan.Case presentationHere, we report a case of a patient who underwent L4‐S1 TLIF at another hospital 4 years ago, accompanied by recurrent pain and discomfort of the left lower limb after the operation. Due to recent condition aggravation, it was considered to be caused by compression of the nerve root due to cage retropulsion. Nerve root sealing and endoscopy surgery were performed on the operative segment. It was found that cage retropulsion at the L4/5 level was a suspicious focus according to careful analysis of the clinical manifestations of the patient. Selective block of the nerve root on the level resulted in relief of the patient's original symptoms. After the posterior edge of the cage was exposed under the endoscope through an intervertebral foramen approach, the posterior edge of the cage protruding into the spinal canal was removed by high‐speed burr grinding, working casing reduction and other methods. Postoperative symptoms of pain in the low back and lower limb were relieved completely.ConclusionsIt is feasible to use the power system to remove the retrograde cage under the endoscope through the intervertebral foramen approach for the revision of symptomatic polyether ether ketone (PEEK) cage retropulsion in the long term after TLIF.
The effectiveness and feasibility of using multi‐lead ECG monitoring combined with a programmed intracavitary ECG to complete left bundle branch area pacing
Authors: Wang Min , Sun Yaxun , Shan Yu , Zhang Jiefang , Sheng Xia , Ye Yang , Yang Ying , Fu Guosheng 
Published: February 2023

AbstractBackgroundLeft bundle branch area pacing (LBBaP) as an alternative method for delivering physiological pacing, is difficult for many primary hospitals that lack the electrophysiological multichannel recorder to carry out. We hope to find a simple and feasible method that combines the multi‐lead surface electrocardiogram (ECG) monitoring and the intracavity ECG of the pacing programmer to achieve LBBaP.MethodsA total of 50 patients with bradycardia indications who attempted permanent pacemaker implantation were included in this study. We referred to multi‐lead surface ECG monitoring and pacing system analyzer (PSA), combined with the nine‐zone pacing method of the LBBaP, to complete LBBaP. We assessed multiple parameters to verify whether the LBBaP was successfully achieved and used univariable analysis of variance for repeated measures to judge the feasibility and effectiveness of LBBaP without the electrophysiological multichannel recorder.ResultsLBBaP was successfully archived without the electrophysiological multichannel recorder in 44 of 50 patients (88%). In the study, paced QRS duration and the stimulus to peak left ventricular activation time (Sti‐LVAT) were 117.04 ± 10.34 ms and 71.10 ± 7.91 ms and had no significant changes in the 3‐month follow‐up. The unipolar pacing threshold and R‐wave amplitudes were 0.85 ± 0.32 V and 10.36 ± 5.24 mV at baseline respectively, which also showed stability during the 1‐month and 3‐month follow‐up. During the 3‐month follow‐up, no lead‐related complication was recorded.ConclusionIt is effective and feasible to achieve LBBaP combining the multi‐lead ECG monitoring and the intracavitary ECG of PSA without the electrophysiological multichannel recorder, which could be an alternative to perform LBBaP.
New record of Sporochnus dotyi (Sporochnales, Phaeophyceae) from Kii Peninsula, Japan
Authors: Kawai Hiroshi , Sherwood Alison R. , Ui Shinsuke , Hanyuda Takeaki 
Published: February 2023

SUMMARYThe subtidal brown algal species Sporochnus dotyi Brostoff (Sporochnales, Phaeophyceae), which has been regarded as a Hawaiian endemic, is reported from Kushimoto, Kii Peninsula, Pacific coast of central Honshu, Japan, for the first time outside Hawai'i. The species grew on subtidal rocks ca. 5–20 m deep attached by a small conical holdfast. The erect thalli were 5–30 cm high, terete, robust and alternately branched in 1–2 orders. When mature, pedicellate receptacles developed on the branches, and formed elliptical sori 1 mm long with a pedicel 3–5 mm long. The apical parts of the thalli and the receptacles were terminated with a tuft of simple assimilatory filaments of up to 4 mm long and showed prominent green to yellow underwater iridescence. Reproductive filaments (paraphyses) were densely packed, simple, up to 200 μm long and bore 4–6 mostly unilateral unilocular zoidangia 20–22 μm long and 5–6 m in diameter. In the genetic analyses, the Sporochnus alga from Kushimoto had partial rbcL sequence identical to S. dotyi from Hawai'i. The cox3 phylogeny revealed that this alga formed a fully supported clade with S. dotyi. Therefore, we identified the alga from Kushimoto as S. dotyi. This finding of S. dotyi from Japan, together with the recent reports of the mesophotic macroalgae Ryuguphycus kuaweuweu (=Umbraulva kuaweuweu), Ulva iliohaha and Newhousia imbricata from various localities in the Pacific Ocean including Japan, suggest closer biogeographical connections of subtidal/mesophotic macroalgae in the Pacific than previously recognized.
Indirect regulation of HIPPO pathway by miRNA mediates high‐intensity intermittent exercise to ameliorate aging skeletal muscle function
Authors: Ni Pin‐Shi , Ma Song , Wang Zhuang‐Zhi , He Jia‐Han , Zhang Chen‐Kai , Li Bo‐Ming , Yu Xiao‐Ming , Li Fang‐Hui 
Published: February 2023

Exercise‐induced microRNA (miRNA) and HIPPO pathways participate in the regulation of skeletal muscle plasticity but their underlying mechanisms remain unclear. We aimed to investigate the effect of high‐intensity interval training (HIIT) on miRNA expression and the HIPPO pathway in the skeletal muscle of aging rats to determine its role in the amelioration of muscle aging. Thirty‐six 18‐month‐old female rats were randomly divided into sedentary control (SED, n = 12), moderate‐intensity continuous training (MICT, n = 12), and HIIT (n = 12) groups, with continuous exercise for 8 months. Quantitative reverse transcription‐polymerase chain reaction, immunoblotting, KEGG enrichment, and dual‐luciferase assays were performed on the target skeletal muscle. Compared with the SED group, the MICT and HIIT groups showed a significant trend of improvement in Lee's index and grip strength and a marked increase in skeletal muscle mitochondrial function, apoptosis, antioxidant, and lipolysis‐related protein expression. They also exhibited PI3K/AKT pathway activation and a decrease in expression of HIPPO pathway‐related proteins; 20 miRNAs were differentially expressed and enriched in the exercise group compared with the SED group, including the HIPPO pathway and metabolic pathways. Further analysis of L6 cells confirmed that miR‐182 may target PTEN, which indirectly regulates HIPPO signaling, but not Mob1. the combined application of HIIT and MICT increased the antioxidant and lipolytic capacities of skeletal muscle and improved atrophy of aging skeletal muscle; HIIT was more effective than MICT. This may be related to HIIT‐mediated AKT pathway activation and HIPPO pathway inhibition by miRNAs (miR‐486 and miR‐182).
Comparison of computerized provider order entry specific transfusion indications versus the use of “Other”
Authors: Tong Nicholas , King Jessica , Fomani Katayoun 
Published: February 2023

AbstractBackgroundComputerized physician order entry (CPOE) systems are one way to reinforce evidence‐based transfusion indications for blood products. The new CPOE system that was implemented at our institution allowed healthcare providers to select “Other” as an indication and provide reasons for transfusion outside of accepted guidelines.Study Design and MethodsTransfusion order records for packed red blood cells (RBCs), platelets, and fresh frozen plasma (FFP) from high product‐ordering areas of Long Island Jewish Medical Center and Cohen's Children's Medical Center from April 2021, when the new CPOE system was implemented, to November 2021 were reviewed. The percentage of “Other” orders was determined and the reason for each “Other” order was reviewed to identify possible areas for education or valid indications not included in the institutionally recognized indications.Results9.7% of RBC orders, 1.9% of platelet orders, and 18.2% of FFP orders were placed with “Other” as the indication for transfusion (χ22 = 88.5; p < .001). Reasons for “Other” orders were varied, but notable reasons included indications already institutionally accepted such as, bleeding (15.7% of pediatric “Other” RBC orders), hold for OR (14.3% of pediatric and 15.8% of adult “Other” RBC orders), and novel reasons such as FFP for ACE‐inhibitor associated angioedema (84.6% of adult “Other” FFP orders).DiscussionThe findings from our study provide examples of potential difficulties hospitals may encounter when they implement a new computerized physician order entry system. Provider education may play an important role to reduce the number of “Other” orders placed for already recognized indications.
Heuristics for the asymptotics of the number of Sn$S_n$‐number fields
Authors: Shankar Arul , Tsimerman Jacob 
Published: February 2023

AbstractWe give a heuristic argument supporting conjectures of Bhargava on the asymptotics of the number of ‐number fields having bounded discriminant. We then make our arguments rigorous in the case giving a new elementary proof of the Davenport–Heilbronn theorem. Our basic method is to count elements of small height in ‐fields while carefully keeping track of the index of the monogenic ring that they generate.
Families of diffeomorphisms and concordances detected by trivalent graphs
Authors: Botvinnik Boris , Watanabe Tadayuki 
Published: February 2023

AbstractWe study families of diffeomorphisms detected by trivalent graphs via the Kontsevich classes. We specify some recent results and constructions of the second named author to show that those non‐trivial elements in homotopy groups are lifted to homotopy groups of the moduli space of ‐cobordisms . As a geometrical application, we show that those elements in for are also lifted to the rational homotopy groups of the moduli space of positive scalar curvature metrics. Moreover, we show that the same elements come from the homotopy groups of moduli space of concordances of positive scalar curvature metrics on with fixed‐round metric on the boundary .
For children admitted to hospital, what interventions improve medication safety on ward rounds? A systematic review
Authors: King Charlotte , Dudley Jan , Mee Abigail , Tomlin Stephen , Tse Yincent , Trivedi Ashifa , Hawcutt Daniel B 
Published: February 2023

ObjectiveEvery year, medication errors harm children in hospitals. Ward rounds are a unique opportunity to bring information together and plan management. There is a need to understand what strategies can improve medication safety on ward rounds. We systematically reviewed published interventions to improve prescribing and safety of medicines on ward rounds.DesignSystematic review of randomised controlled trials and observational studies.SettingStudies examining inpatient ward rounds.PatientsChildren and young people aged between 0 and 18 years old.InterventionsAny intervention or combination of interventions implemented that alters how paediatric ward rounds review inpatient medications.Main outcome measurePrimary outcome was improvement in medication safety on paediatric ward rounds. This included reduction in prescribing error rates, healthcare professionals’ opinions on prescribing and improvement in documentation on ward rounds.ResultsThree studies were eligible for review. One examined the use of an acrostic, one the use of a checklist, and the other a use of a specific prescribing ward round involving a clinical pharmacist and doctor. None of the papers considered weight-based errors or demonstrated reductions in clinical harm. Reductions in prescribing errors were noted by the different interventions.ConclusionsThere are limited data on interventions to improve medication safety in paediatric ward rounds, with all published data being small scale, either quality improvement or audits, and locally derived/delivered. Good-quality interventional or robust quality improvement studies are required to improve medication safety on ward rounds.PROSPERO registration numberCRD42022340201.
metaumbrella: the first comprehensive suite to perform data analysis in umbrella reviews with stratification of the evidence
Authors: Gosling Corentin J , Solanes Aleix , Fusar-Poli Paolo , Radua Joaquim 
Published: February 2023

ObjectiveUmbrella reviews are a new form of literature review that summarises the strength and/or quality of the evidence from all systematic reviews and meta-analyses conducted on a broad topic. This type of review thus provides an exhaustive examination of a vast body of information, providing the highest synthesis of knowledge. A critical strength of umbrella reviews is recalculating the meta-analytic estimates within a uniform framework to allow a consistent evidence stratification. To our best knowledge, there is no comprehensive package or software to conduct umbrella reviews.MethodsThe R package metaumbrella accomplishes this aim by building on three core functions that (1) automatically perform all required calculations in an umbrella review (including but not limited to pairwise meta-analyses), (2) stratify evidence according to various classification criteria and (3) generate a visual representation of the results. In addition, this package allows flexible inputs for each review or meta-analysis analysed (eg, means plus SD, or effect size estimate and CI) and customisation (eg, stratification criteria following Ioannidis, algorithmic GRADE or personalised classification).ResultsThe R package metaumbrella thus provides the first comprehensive range of facilities to perform umbrella reviews with stratification of the evidence.ConclusionTo facilitate the use of this package, even for researchers unfamiliar with R, we also provide a JAMOVI module and an open-access, browser-based graphical interface that allow use of the core functions of the package with a few mouse clicks.