bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced ammonia removal from skim latex using air bubbles in an agitated column
Authors: Kokoo Rungrote , Rattanakam Ramida , Myint Maung Si Thu , Khangkhamano Matthana 
Published: January 2023

AbstractThe initial aim of the paper is to improve the ammonia removal efficiency from skim latex using air stripping in an agitated column. The effects of air flow rate, bubble sizes, types of impellers, and rotational speed were investigated. The results showed that ammonia decreased with the increased air flow rate and the decreased bubble size. More ammonia could be removed by the use of impellers at a low rotational speed. The axial flow impeller showed higher ammonia removal than that gained from the radial flow impeller. It could be concluded that the stripping process in an agitated column should be operated at an air flow rate under the homogeneous regime without pH and temperature adjustment. The use of axial flow impeller at a rotational speed below the turbulent flow is recommended for more ammonia removal. In addition, smaller bubbles than the working range proposed in this research should be avoided because of foaming formation of the skim latex.
Combining povidone‐iodine with vancomycin can be beneficial in reducing early biofilm formation of methicillin‐resistantStaphylococcus aureus and methicillin‐sensitiveS. aureus on titanium surface
Authors: Taha Mariam , Arulanandam Rozanne , Chen Andrew , Diallo Jean‐Simon , Abdelbary Hesham 
Published: January 2023

AbstractThere is controversial clinical evidence regarding the added antibacterial benefit of locally administering antiseptic solutions or antibiotics to the infected joint space. The objectives of this in vitro study were to test the efficacy of povidone‐iodine (PVP‐I) and vancomycin in treating premature and developed Staphylococcus aureus biofilms grown on titanium implant surfaces. PVP‐I and vancomycin were used to treat immature and developed biofilms formed by two clinical strains of S. aureus (BP043‐MRSA, PB011‐MSSA). S. aureus strains were grown as immature (3 h‐old) or developed (24 h‐old) biofilm. These biofilms were grown on titanium plasma sprayed discs. The treatment regimens tested were: 0.8% PVP‐I, 500 μg/ml vancomycin as well as a combination of vancomycin and PVP‐I. PVP‐I was tested at 3 min, as per current clinical practice, versus 1 min treatment times. In addition, the cytotoxicity of the PVP‐I and vancomycin was tested using fresh skeletal muscle tissue cores harvested from the rat's abdominal muscles using alamarBlue assay. The combination of PVP‐I (3 min) and vancomycin (24 h.) showed synergistic interaction and the best efficacy against immature biofilms formed by both clinical strains. This degree of eradication was statistically significant compared to the untreated control, p < .0001. However, this combination therapy had limited efficiency against developed biofilms. Also, PVP‐I alone was more effective when exposure time was 3 min instead of 1 min against immature biofilm for MRSA, p = .02, and MSSA, p = .01. PVP‐I and vancomycin were not effective against developed biofilm regardless of exposure time. Also, combining PVP‐I and vancomycin was not cytotoxic to muscle tissue. Combining PVP‐I with vancomycin is superior in reducing viable S. aureus cells in immature biofilms grown on titanium surface without causing significant cytotoxicity to muscle tissue. Exposure times and biofilm maturity play a role in dictating the efficacy of using local antiseptics and antibiotics to treat biofilms on implant surfaces.
Seven‐day vonoprazan‐based triple therapy as first‐lineHelicobacter pylori treatment in comparison with extended sequential therapy
Authors: Chiu Yu‐Tse , Lee Fu‐Jen , Kuo Chen‐Ya , Lin Yang‐Chao , Liang Kai‐Shun , Tseng Liang‐Wei , Chen Yu‐Tsung , Chang Chi‐Yang 
Published: January 2023

AbstractBackground and AimVonoprazan as a new acid blocker has more potency and longer lasting acid suppression than proton pump inhibitors. Whether the efficacy of vonoprazan‐based triple therapy is comparable with or even better than that of currently recommended first‐line therapies is still unknown. Our study aims to compare the eradication rate and major adverse effects between 7‐day vonoprazan‐based triple therapy with high‐dose amoxicillin and 14‐day extended sequential therapy.MethodsWe performed a retrospective analysis from the database of 13C‐urea breath test at Fu Jen Catholic University Hospital. All patients with a definite diagnosis of Helicobacter pylori infection by rapid urease test, urea breath test, stool antigen test, or pathology report were recruited. Patients receiving first‐line regimens with vonoprazan‐based triple therapy or extended sequential therapy were included. The respective eradication rate determined by 13C‐urea breath test and major adverse effects were demonstrated.ResultsTotally, 106 patients were recruited in the vonoprazan‐based triple therapy group and 357 in the extended sequential therapy group. There was no significant difference in eradication rate between vonoprazan‐based triple therapy with high‐dose amoxicillin and extended sequential therapy (83.0 vs 88.8%, P = 0.12). Major adverse effects occurred in 13 of the extended sequential therapy group but none in the other group (0% vs 3.6%, P = 0.046).ConclusionsSeven‐day vonoprazan‐based triple therapy with high‐dose amoxicillin is a potential first‐line anti‐Helicobacter pylori regimen alternative to current standard treatment, with the advantages of simplicity, short treatment duration, low pill burden, and fewer major adverse effects.
Discontinuation of immunosuppression in patients with immune‐mediated drug‐induced liver injury or idiopathic autoimmune hepatitis: A case–control study
Authors: Hassoun Jeremy , Goossens Nicolas , Restellini Sophie , Ramer Lucas , Ongaro Marie , Giostra Emiliano , Hadengue Antoine , Rubbia‐Brandt Laura , Spahr Laurent 
Published: January 2023

AbstractBackground and AimDrug‐induced liver injury (DILI) may present with autoimmune features and require immunosuppressive therapy (IST) to reach biochemical response. Discontinuation of IST without hepatitis relapse may be more frequent in these patients as compared to patients with classical autoimmune hepatitis (AIH). We aimed to determine baseline characteristics and outcome of patients with immune‐mediated drug induced liver injury (IMDILI) with particular emphasis on IST during follow‐up.MethodsWe performed a single‐center retrospective study of consecutive patients presenting at a tertiary care center between January 2005 and December 2019 either with IMDILI or with classical AIH, for whom full baseline characteristics and a close follow‐up were available over a 12‐month period.ResultsOverall, 31 patients (IMDILI n = 16, mean age 59 [34–74] years; AIH n = 15, mean age 47 [15–61] years) were included, showing similar biochemical, serological, and histological characteristics. Incriminating drugs in IMDILI patients were mostly represented by nonsteroidal antiinflammatory drugs and sartans. Initial corticosteroids combined with IST led to biochemical response in all patients. Compared to idiopathic AIH, more patients with IMDILI were weaned off corticosteroids at the end of follow‐up (11/16 [68.7%] vs 4/15 [26.6%], P < 0.02). At 1 year of follow‐up, more patients in the IMDILI group compared to the classical AIH group were off any type of IST (13/16 [81%] vs 15/15 [100%], P = 0.08).ConclusionsAlthough presenting with similar baseline biochemical and histological characteristics as idiopathic AIH, patients with IMDILI may not require long‐term IST.
Investigating the mechanism of action of ginkgolides and bilobalide on absence seizures in maleWAG/Rij rats
Authors: Gedikli Öznur , Akca Metehan , Yildirim Mehmet 
Published: January 2023

AbstractThe effects of a single and multiple doses of ginkgolide A, B, C, and bilobalide, active components ofGinkgo bilobaextract (EGb 761), on absence seizures were investigated in male WAG/Rij rats, a genetic animal model of absence epilepsy. Furthermore, the interactions of ginkgolide A together with NMDA receptor antagonist MK‐801, AMPA/kainate receptor antagonist 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX), or L‐type calcium channel blocker nicardipine were studied to figure out how ginkgolide A affects spike–wave discharges (SWDs) in the brain. The experiments were done using 6–8‐month‐old male WAG/Rij rats with infusion cannula and EEG electrode implanted. Ginkgolide A, B, C, and bilobalide were administered intraperitoneally for 7 days at a dose of 6 mg/kg. In interaction groups, 6 μg ginkgolide A was injected intracerebroventricularly in combination with MK‐801 (10 μg), CNQX (1 μg), and nicardipine (50 μg) for 7 days. EEG was recorded from animals at the baseline, first dose, and seventh dose periods for 4 h. Ginkgolide A (p = .028), C (p = .046), and bilobalide (p = .043) significantly increased the frequency of SWDs in WAG/Rij rats. Ginkgolide A injected into the lateral ventricle with MK‐801 (p = .046), CNQX (p = .043), and nicardipine (p = .046) significantly increased the number of SWDs after seventh dose. Finally, the EGb 761‐related increase in absence epilepsy was determined to be caused by ginkgolide A, C, and bilobalide. All three receptor antagonists/channel blockers do not inhibit the pro‐absence effect of ginkgolide A. The findings revealed that ginkgolide A's pro‐absence effect is mediated by brain circuits other than ionotropic glutamate receptors or L‐type calcium channels.
Formulation for chemical EOR: Development and evaluation of an ASP formulation In customer field conditions
Authors: Herman George , Bittner Christian , Lohateeraparp Prapas , Mai Kahnery , Watts Nathan , Bueschel Michael 
Published: January 2023

AbstractAlkali surfactant polymer (ASP) flooding is an enhanced oil recovery (EOR) technology with an impressive potential for increasing incremental oil production from conventional hydrocarbon bearing reservoirs. A challenge to ASP application is the complexity of determining an effective formulation, typically requiring extensive laboratory screening of nearly countless combinations of surfactants and cosolvents. This paper focuses on demonstrating the utility of the hydrophilic–lipophilic deviation (HLD) concept for EOR application to simplify surfactant formulation workstreams seeking an economically viable ASP formulation for field application. In describing work performed for EOR application of ASP under customer conditions using crude oil, the discussion covers the initial evaluation of the promising surfactant formulation (interfacial tension and solubility), the improvement upon the formulation via HLD principles, and the evaluation of the improved surfactant formulation (coreflood studies). The final ASP formulation identified consisted of a 9 to 1 mixture of alkyl propoxy sulfate sodium salt (APS) to alkyl ethoxy sulfate sodium salt (AES) totaling 2000 ppm active surfactant content, 2.0 wt% Na2CO3, and 3000 ppm polyacrylamide polymer (all commercially available products). This formulation had ultra‐low interfacial tension and favorable mixing behavior under reservoir conditions. In coreflood studies, the final formulation reproducibly achieved cumulative oil recovery of 96.4%–98.5% of original oil in place with only 0.3 PV of ASP injection with a chase alkali polymer injection.
Myeloid Phenotypes in Tracheostomy‐Associated Granulation Tissue
Authors: Berges Alexandra J. , Ospino Rafael , Lina Ioan A. , Collins Samuel , Chan‐Li Yee , Gelbard Alexander , Hillel Alexander T. , Motz Kevin M. 
Published: January 2023

Objective(s)Tracheostomy‐associated granulation tissue is a common, recurrent problem occurring secondary to chronic mucosal irritation. Although granulation tissue is composed of predominantly innate immune cells, the phenotype of monocytes and macrophages in tracheostomy‐associated granulation tissue is unknown. This study aims to define the myeloid cell population in granulation tissue secondary to tracheostomy.MethodsGranulation tissue biopsies were obtained from 8 patients with tracheostomy secondary to laryngotracheal stenosis. Cell type analysis was performed by flow cytometry and gene expression was measured by quantitative real‐time polymerase chain reaction. These methods and immunohistochemistry were used to define the monocyte/macrophage population in granulation tissue and were compared to tracheal autopsy control specimens.ResultsFlow cytometry demonstrated macrophages (CD45+CD11b+) and monocytes (CD45+FSClowSSClow) represent 23.2 ± 6% of the granulation tissue cell population. The M2 phenotype (CD206) is present in 77 ± 11% of the macrophage population and increased compared to the M1 phenotype (p = 0.012). Classical monocytes (CD45+CD14highCD16low) were increased in granulation tissue compared to controls (61.2 ± 7% and 30 ± 8.5%, p = 0.038). Eighty‐five percent of macrophages expressed pro‐inflammatory S100A8/A9 and 36 ± 4% of macrophages co‐localized CD169, associated with tissue‐resident macrophages. M2 gene expression (Arg1/CD206) was increased in granulation tissue (3.7 ± 0.4, p = 0.035 and 3.5 ± 0.5, p = 0.047) whereas M1 gene expression (CD80/CD86) was similar to controls (p = 0.64, p = 0.3). Immunohistochemistry of granulation tissue demonstrated increased cells co‐localizing CD11b and CD206.ConclusionsM2 macrophages are the dominant macrophage phenotype in tracheostomy‐associated granulation tissue. The role of this cell type in promoting ongoing inflammation warrants future investigation to identify potential treatments for granulation tissue secondary to tracheostomy.Level of Evidence3 Laryngoscope, 133:2346–2356, 2023
Taxonomic identity, biodiversity, and antecedent disturbances shape the dimensional stability of stream invertebrates
Authors: Allen Daniel C. , Gill Brian A. , Metcalfe Anya , Bonjour Sophia , Starr Scott , Wang Junna , Valentin Diana , Grimm Nancy B. 
Published: January 2023

AbstractThe “dimensional stability” approach measures different components of ecological stability to investigate how they are related. Yet, most empirical work has used small‐scale and short‐term experimental manipulations. Here, we apply this framework to a long‐term observational dataset of stream macroinvertebrates sampled between the winter flooding and summer monsoon seasons. We test hypotheses that relate variation among stability metrics across different taxa, the magnitude of antecedent (monsoon) and immediate (winter) floods to stability metrics, and the relative importance of disturbance magnitude and taxonomic richness on community dimensional stability. Cluster analysis revealed four distinct stability types, and we found that the magnitude of floods during the prior monsoon was more important in influencing stability than the winter flood itself. For dimensional stability at the community level, taxonomic richness was more important than disturbance magnitude. This work demonstrates that abiotic and biotic factors determine dimensional stability in a natural ecosystem.
The MÉRA Data Extraction toolkit
Authors: Görgü Levent , Hawtree Daniel , O'Grady Michael J. , Muldoon Conor , Masterson Bartholomew , Meijer Wim G. , O'Sullivan John J. , O'Hare Gregory M. P. 
Published: January 2023

AbstractHistorical meteorological datasets are indispensable for forming climatic models and the generation of weather forecasts. Such data are core to the training phase of prediction models and may also be harnessed for hydrological and environmental models. GRIB is the most common data format used in meteorology and represents the de facto standard for storing historical weather data. However, GRIB datasets are complex and do not constitute analysis‐ready data without additional preprocessing. The MÉRA dataset of the Met Eireann, the Irish meteorological service, is archetypical of such datasets, emerging from a high‐resolution climatic reanalysis of Irish weather data between 1981 and 2019. This article describes the MÉRA Data Extractor toolkit. This toolkit enables the intuitive, fast extraction and preprocessing of data from this extensive dataset. The toolkit is available as open source and will be of interest to those researching climate modelling in Europe.
What should a toolkit to aid the delivery of therapeutic exercise for hip and knee osteoarthritis look like? Qualitative analysis of an international survey of 318 researchers, clinicians, and consumers by the OARSI Rehabilitation Discussion Group
Authors: Lawford Belinda J. , Master Hiral , Larsen Jesper B. , Bartholdy Cecilie , Corrigan Patrick , Ginnerup‐Nielsen Elisabeth , Le Christina , Teoli Anthony , Bennell Kim L. , Metcalf Ben , Hinman Rana S. , Button Kate , Collins Natalie J. , Cottrell Elizabeth , Henrotin Yves , Skou Søren T. , Thoma Louise M. , Wellsandt Elizabeth , White Daniel K. , Holden Melanie A. 
Published: January 2023

AbstractBackgroundWe aimed to identify important components of, and practical resources relevant for inclusion in, a toolkit to aid exercise delivery for people with hip/knee osteoarthritis.MethodAn online international multi‐disciplinary survey was conducted across 43 countries (139 clinicians, 44 people with hip/knee osteoarthritis and 135 osteoarthritis researchers). Participants were presented with the seeding statement ‘Practical resources to aid the implementation of exercise for people with hip/knee osteoarthritis should…’ and asked to provide up to 10 open text responses. Responses underwent refinement and qualitative content analysis to create domains and categories.ResultsRefinement of 551 open text responses yielded 72 unique statements relevant for analysis. Statements were organised into nine broad domains, suggesting that resources to aid exercise delivery should: (1) be easily accessible; (2) be of high quality; (3) be developed by, and for, stakeholders; (4) include different ways of delivering information; (5) include different types of resources to support exercise and non‐exercise components of self‐management; (6) include resources on recommended exercises and how to perform/progress them; (7) include tools to support motivation and track progress; (8) include resources to enable tailoring of the programme to the individual and; (9) facilitate access to professional and peer support.ConclusionOur findings identified important components of, and practical resources to include within, a toolkit to aid delivery of exercise for people with hip/knee osteoarthritis. These findings have implications for exercise providers and lay the foundation for the development of a toolkit to help ensure exercise provision aligns with current international recommendations.
Synthesis and characterization of hollow mesoporous silica nanocomposites containing phosphorescent pigment and doxycycline
Authors: Alam Zahra , Ghamami Shahriar , Baghshahi Saeid 
Published: January 2023

AbstractHollow mesoporous silica can be used as a carrier to store large amounts of drugs in pharmaceuticals due to its high surface area and suitable porosity. Therefore, the purpose of this study was to develop a SrAl2O4:Eu2+,Dy3+ hollow mesoporous silica and apply for loading and tracking of doxycycline (DOX) release. The structure and particle morphology were investigated by X‐ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM) pictures, respectively. Photoluminescence (PL) spectra revealed that the phosphors had efficient luminescent and long‐lasting properties. Finally, according to the obtained results, the amount of drug loading in hollow mesoporous regular silica was 35% and the drug release from hollow mesoporous regular silica was gradual and controlled.
Hospital practitioner views on the benefits of continence education and best ways to provide training
Authors: Percival John , Abbott Katharine , Allain Theresa , Bradley Rachel , Cramp Fiona , Donovan Jenny , McCabe Candy , Neubauer Kyra , Redwood Sabi , Cotterill Nikki 
Published: January 2023

AbstractAimThe aim of the study was to explore practitioners' experiences and perspectives on continence training, in order to understand its relevance to practice and how take‐up of, and engagement with, such training may be improved.Design27 qualitative interviews were conducted with nursing, medical and allied health practitioners in three hospitals.MethodsWe analysed data thematically, both manually and with the aid of NVivo software. The research adheres to the consolidated criteria for reporting qualitative research checklist.ResultsPractitioners asserted the likely benefits of evidence‐based continence training, including more judicious use of products, reduction in associated infection, better patient skin care and more facilitative communication with patients. Practitioners also identified preferred methods of continence training, according to their role and workload. To ensure better take‐up of, and engagement with, continence training, it must be authorized as essential and provided in ways that reflect professional preferences and pragmatic resource considerations.
Registration of UPR‐Mp‐34 and UPR‐Mp‐42 common bean germplasm with enhanced resistance to ashy stem blight
Authors: Viteri Diego M. , Linares‐Ramírez Angela M. , Miranda Zoralys , Vázquez Roberto 
Published: January 2023

AbstractCommon bean (Phaseolus vulgaris L.) breeding lines (BL) UPR‐Mp‐34 (Reg no. CV‐313, PI 701379) and UPR‐Mp‐42 (Reg no. CV‐314, PI 701380) were developed at the University of Puerto Rico. UPR‐Mp‐34 was derived from A 195/‘PC 50’//SEA 5, and UPR‐Mp‐42 was developed from BAT 477/NY6020‐4//PRA154 common bean populations. Both BL have intermediate levels of resistance (mean scores, 4–6) to two inoculations of the PRI21 Macrophomina phaseolina (Tassi) Goidanich isolate (the causal agent of ashy stem blight) compared with BAT 477, SEA 5, TARS‐MST1, and XAN 176, which mostly had susceptible scores (7–9) in the greenhouse and field evaluations. UPR‐Mp‐34 has an indeterminate growth habit Type III, has a cream seed (average weight, 26.5 g per 100 seeds), initiates flowering at 32 d after planting, and reaches harvesting maturity at 86 d. Mean seed yield was 730 and 340 kg ha−1 in Isabela and Lajas, respectively. UPR‐Mp‐42 possesses black seed (23.8 g per 100 seeds), has a determinate growth habit Type I, initiates flowering at 30 d, and matures at 76 d. Mean seed yield was 750 kg ha−1 in both locations. The intermediate levels of ashy stem blight resistance from both BL could be combined with other sources of resistance and introgressed into common bean cultivars from different market classes.