bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Energy Blue Pulsed Light‐Activated Injectable Materials for Restoring Thinning Corneas
Authors: MacAdam Aidan J. , Munoz Marcelo , Hage Jinane El , Hu Kevin , Ross Alex , Chandra Astha , Edwards Jodi D. , Shahid Zian , Mourcos Sophia , Comtois‐Bona Maxime E. , Juarez Alejandro , Groleau Marc , Dégué Delali Shana , Djallali Mohamed , Piché Marilyse , Thériault Mathieu , Grenier Michel , Griffith May , Brunette Isabelle , Alarcon Emilio I. 
Published: July 2023

AbstractMany alternatives to human donor corneas are being developed to meet the global shortage of donated tissues. However, corneal transplantation remains the gold standard for diseases resulting in thinning corneas. In this study, transparent low energy photoactivated extracellular matrix‐mimicking materials are developed for intrastromal injection to restore stromal thickness. The injectable biomaterials are comprised of short peptides and glycosaminoglycans (chondroitin, hyaluronic acid) that assemble into a hydrogel when pulsed with low‐energy blue light. The dosage of pulsed‐blue light needed for material activation is minimal at 8.5 mW cm−2, thus circumventing any blue light cytotoxicity. Intrastromal injection of these light‐activated biomaterials in rat corneas shows that two iterations of the formulations remain stable in situ without stimulating significant inflammation or neovascularization. The use of low light intensities and the ability of the developed materials to stably rebuild and change the curvature of the cornea tissue make these formulations attractive for clinical translation.
3D Nanoarchitectured Hexagonal Boron Nitride with Integrated Single Photon Emitters
Authors: Aleman Christopher Florencio , Lyu Jiecheng , Noyan Mehmet A. , McCreary Kathleen M. , Han Jiuhui , Johnson Isaac , Gao Qingyang , Niebur Maximilian , Jonker Berend T. , Chen Mingwei 
Published: July 2023

AbstractTwo‐dimensional (2D) hexagonal boron nitride (hBN) is one of the most promising candidates to host solid‐state single photon emitters (SPEs) for various quantum technologies. However, the 2D nature with an atomic‐scale thickness leads to inevitable challenges in spectral variability caused by substrate disturbance, lattice strain heterogeneity, and defect variation. Here, three‐dimensional (3D) nanoarchitectured hBN is reported with integrated SPEs from native defects generated during high‐temperature chemical vapor deposition (CVD). The 3D hBN has a quasi‐periodic gyroid minimal surface structure and is composed of a continuous 2D hBN sheet with built‐in convex and concave curvatures that promote the formation of optically active and thermally robust native defects. The free‐standing feature of the gyroid hBN with a nearly zero mean curvature can effectively eliminate the substrate disturbance and minimize lattice strain heterogeneity. As a result, naturally occurring defects with a narrow SPE spectral distribution can be created and activated as color centers in the 3D hBN, and the density of the SPEs can be tailored by CVD temperature.
Dispersion‐Engineered Deep Sub‐Wavelength Plasmonic Metasurfaces for Broadband Seira Applications
Authors: Dixon Katelyn , Zhu Xiangchao , Chen Liang , Montazeri Arthur , Matsuura Naomi , Kherani Nazir P. , Holman Hoi‐Ying N. 
Published: July 2023

AbstractSurface enhanced infrared absorption (SEIRA) spectroscopy is a powerful tool in which plasmonically enhanced electromagnetic fields provide high‐sensitivity molecular detection. Most SEIRA platforms operate at a single resonant frequency, which must be tuned to match that of the target molecule, and commonly rely on time‐consuming lithographic techniques. This study presents a high‐throughput and cost‐effective plasmonic metasurface for broadband, tunable, and strong infrared signal enhancement. The platform is built upon the principle of dispersion‐engineered plasmonic Fabry–Pérot (FP) nanocavity arrays. It offers 1) tight squeezing of infrared (IR) photons into deep sub‐wavelength nano‐volumes and 2) spectrally tunable near‐field enhancements of up to ≈106, two to three orders of magnitude higher than most optical metasurface systems. By coupling multilayer nano‐thin film deposition and nanoskiving fabrication techniques, the dispersive FP metasurfaces can be rapidly and reproducibly constructed in a scalable and lithography‐free manner. Using IR spectroscopy, the selective and sensitive label‐free detection of a molecular monolayer is achieved at a range of frequencies. An enhancement factor of nearly 105 is measured at the carbonyl (C = O) vibrational marker band of the molecule. The confluence of high field enhancement, broadband plasmonic response, and facile fabrication makes this metasurface a promising platform for SEIRA spectroscopy.
The impact of post‐mastectomy radiation timing on overall outcomes of autologous free‐flap breast reconstruction
Authors: Parmeshwar Nisha , Barnes Laura , Martins Deborah , Nicholas Catherine , Piper Merisa 
Published: July 2023

AbstractBackgroundThe optimal timing of post‐mastectomy radiation therapy (PMRT) in autologous breast reconstruction is controversial. Our study compares overall reconstructive outcomes in patients who received post‐mastectomy radiation therapy either before or after the autologous flap.MethodsA single‐center retrospective review was performed for patients who underwent free flap breast reconstruction and post‐mastectomy radiation from January 2004 through January 2021. Demographic, intraoperative, and post‐operative variables were recorded.ResultsA total of 452 free flaps were identified, and 82 underwent PMRT. 59.8% were radiated with an expander prior to free flap surgery (PreFlap), and 40.2% flaps underwent PMRT (PostFlap). PostFlap patients were significantly younger (43.0 vs. 47.9 years, p = .016). There were no significant differences in free flap outcomes between the two cohorts including thrombosis, venous congestion, flap loss, takebacks, fat necrosis, seroma, or infection. Mastectomy skin flap necrosis was significantly higher in the PostFlap cohort (9.1% vs. 0%, p = .032), but nipple necrosis rates did not differ. There were no significant differences in number or need for revision surgeries, fat necrosis, or fat grafting between groups. However, there were significantly more total reconstructive complications, including infection and wound breakdown, experienced by the PreFlap cohort (46.9% vs. 24.2%, p = .038).ConclusionsTiming of PMRT did not impact free flap outcomes, but those who had the expander radiated experienced significantly more complications overall. For the 34.7% of patients in the preFlap group who planned for autologous reconstruction form initial consultation, radiation after the flap may have improved their overall outcomes. As added complications cause delays in cancer therapy and final reconstruction, our results suggest that PMRT of the flap when possible may improve the overall experience for breast cancer patients.
Network advantage: Uncontested structural holes and organizational performance in market crises
Authors: Shipilov Andrew , Li Stan X. , Bothner Matthew S. , Truong Nghi 
Published: July 2023

AbstractResearch SummaryWe examine how crisis conditions affect the link between structural holes and organizational performance. Since brokerage offers early access to diverse perspectives and autonomy in exchange relations, the benefits of brokerage should rise when crises erupt. However, evidence on the subject has been inconclusive, raising the question of whether crisis actually imposes a boundary condition on structural hole theory. Using longitudinal data on investment banks, and exploiting the 2000 dot.com crisis as well as the 2008 financial crisis, we explore whether crises moderate the favorable effect of brokerage on performance. Our results reveal that only exclusive, and not shared, structural holes are advantageous for performance, as they facilitate ambidextrous responses to crisis. Implications for brokerage theory and new research on crisis are discussed.Managerial SummaryCrises, in the form of pandemics, wars, or market crashes, affect the relationship between a firm's position in collaboration networks and its future performance. Our analyses bring into focus a finding of interest to managers of firms operating as brokers in these networks: when a crisis erupts, a firm that serves as the sole bridge between its otherwise disconnected collaborators performs especially well. Uncontested by other intermediaries, such firms achieve a better mix of search and stability, and thus higher performance, amidst crisis. These advantages disappear when other intermediaries are present. This implies that firms frequently exposed to crisis may benefit from constructing entry barriers around their bridging positions in collaboration networks.
Towards Sustainable Digitization
Authors: Blersch Daniel , Held Christoph , Mettenleiter Markus , Fröhlich Christoph 
Published: July 2023

AbstractComplexity and data quality of a project are strongly linked together. The higher the need for better data quality is, the more complex projects become. In digitization, various complexity factors have an impact on the quality, such as the object properties or environmental factors. However, it also largely depends on the employed technology. Digitization instruments are designed for specific purposes and applications and have defined specifications and limitations. Some devices perform better with one material or another, and can capture invisible detail or geometry at large distance.The aim of a holistic documentation often implies to take into account significant amount of additional data and of different nature. Equipping devices with multiple sensors, allows capturing more information and detail at the same time, which means a massive increase of data - intensifying the challenge. Thus, it is mandatory to be aware of the strengths and limitations to decide which technology, or a combination thereof, fits best for each case.Smart technological ideas and sensor design can mitigate the complexity. At the example of terrestrial 3D laserscanners by Zoller + Fröhlich, this article provides insight to manufacturer’s strategies about ensuring maximum survey quality and proposing efficient solutions for complexity reduction in survey projects. The technological answers range from sensorial adaptions to sophisticated workflow approaches and the incremental use of intelligent algorithms to an outlook on the necessary focus for the future. The approaches are illustrated with examples from emblematic use cases of outstanding tangible Heritage digitization in Europe.
The Holistic Documentation of Movable Cultural Heritage Objects - The Case of the Antikythera Mechanism
Authors: Efstathiou Kyriakos , Efstathiou Marianna , Basiakoulis Alexandros , Cliffen Harriet , Joncic Nenad , Georgiou Rafaella 
Published: July 2023

AbstractThe Antikythera Mechanism is the oldest extant complex geared device, and an amazing example of an early analogue computer. It was built approximately 2150 years ago. The device was operated manually by a user, who would set a date on a dial. All necessary calculations were made using a set of gears (at least 39), while the results were displayed on several scientific scales. The Mechanism was used to calculate the diurnal and annual motion of the Sun, the Moon and probably the planets among the stars. It implemented the astronomical knowledge of ancient Greeks about the motion of these celestial bodies with astonishing accuracy, taking into account the anomalous orbit of the Moon using a system of eccentric gears. It could also predict eclipses of the Sun and the Moon from the Saros period, which was found in one of its scales. It calculated the dates of the major crown games that took place in ancient Greece (e.g. the Olympic Games). Finally, it was accompanied by an extended User’s Manual. More than 20 references to astronomical mechanisms can be found in classical literature from 50 BC to 500 AD. In this study, the first approach for a holistic documentation of the Antikythera Mechanism is presented.
In-vitro model to mimic T cell subset change in human PDAC organoid co-culture
Authors: Knoblauch M. , Ma T. , Beirith I. , Koch D. , Hofmann F. , Heinrich K. , Aghamaliev U. , Sirtl S. , Westphalen C. B. , Nieß H. , Reichert M. , Angele M. K. , Regel I. , Bazhin A. V. , Werner J. , Ilmer M. , Renz Bernhard W. 
Published: July 2023

Abstract
Purpose
Immunotherapies have largely failed as treatment options for pancreatic ductal adenocarcinoma (PDAC). In this field, clinical translational studies into personalized treatment are of fundamental importance. In our study, we model tumor-cell immune-cell interactions in a co-culture of primary human PDAC organoids and matched peripheral blood mononuclear cells (PBMCs).

Methods
Using flow cytometry, we evaluated changes in T cell subtypes upon co-culture of patient-derived PDAC organoids and matched PBMCs.

Results
After co-culturing PDAC organoids with PBMCs, we observed changes in CD4+, CD8+ and Treg cell populations. We observed favorable clinical outcome in patients whose PBMCs reacted to the co-culture with organoids.

Conclusion
This experimental model allows to investigate interactions between patient derived PDAC organoids and their PBMCs. This co-culture system could serve as a preclinical platform to guide personalized therapeutic strategies in the future.
Current status of molecular diagnostic approaches using liquid biopsy
Authors: Takahashi Kenji , Takeda Yohei , Ono Yusuke , Isomoto Hajime , Mizukami Yusuke 
Published: July 2023

AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers, and developing an efficient and reliable approach for its early-stage diagnosis is urgently needed. Precancerous lesions of PDAC, such as pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasms (IPMN), arise through multiple steps of driver gene alterations in KRAS, TP53, CDKN2A, SMAD4, or GNAS. Hallmark mutations play a role in tumor initiation and progression, and their detection in bodily fluids is crucial for diagnosis. Recently, liquid biopsy has gained attention as an approach to complement pathological diagnosis, and in addition to mutation signatures in cell-free DNA, cell-free RNA, and extracellular vesicles have been investigated as potential diagnostic and prognostic markers. Integrating such molecular information to revise the diagnostic criteria for pancreatic cancer can enable a better understanding of the pathogenesis underlying inter-patient heterogeneity, such as sensitivity to chemotherapy and disease outcomes. This review discusses the current diagnostic approaches and clinical applications of genetic analysis in pancreatic cancer and diagnostic attempts by liquid biopsy and molecular analyses using pancreatic juice, duodenal fluid, and blood samples. Emerging knowledge in the rapidly advancing liquid biopsy field is promising for molecular profiling and diagnosing pancreatic diseases with significant diversity.
Short-term forecasting of typhoon rainfall with a deep-learning-based disaster monitoring model
Authors: Kim Doyi , Choi Yeji , Seo Minseok , Shin Seungheon , Jeong Hyun-Jin 
Published: July 2023

Abstract
Accurate and reliable disaster forecasting is vital for saving lives and property. Hence, effective disaster management is necessary to reduce the impact of natural disasters and to accelerate recovery and reconstruction. Typhoons are one of the major disasters related to heavy rainfall in Korea. As a typhoon develops in the far ocean, satellite observations are the only means to monitor them. Our study uses satellite observations to propose a deep-learning-based disaster monitoring model for short-term typhoon rainfall forecasting. For this, we consider two deep learning models: a video frame prediction model, Warp and Refine Network (WR-Net), to predict future satellite observations and an image-to-image translation model, geostationary rainfall product (GeorAIn) (based on the Pix2PixCC model), to generate rainfall maps from predicted satellite images. Typhoon Hinnamnor, the worst typhoon case in 2022 in Korea, is selected as a target case for model verification. The results show that the predicted satellite images can capture the structures and patterns of the typhoon. The rainfall maps generated from the GeorAIn model using predicted satellite images show a correlation coefficient of 0.81 for 3-hr and 0.56 for 7-hr predictions. The proposed disaster monitoring model can provide us with practical implications for disaster alerting systems and can be extended to flood-monitoring systems.
Gendered Violence, Victim Credibility and Adjudicating Justice in Augustine's Letters
Authors: Leonard Victoria 
Published: July 2023

AbstractIn their focus on queer sexuality, letters 77 and 78 in Augustine's letter collection are unusual. Same-sex acts and sexual violence are mostly tightly controlled and deliberately erased in antiquity. This article looks again at the case of sexual abuse preserved in letters 77 and 78 between the monk Spes and the presbyter Bonifatius, applying modern critical understandings of gendered violence, victimisation and harm to reach beyond previous critical approaches that have seen the exceptionalism of the case as a reason not to engage with it. This research takes a new critical approach, re-situating the incident within the wider context of gendered violence in Augustine's letters. It engages with the case of sexual abuse solely between men intrinsically, and as a uniquely available point of comparison with sexual violence perpetrated by men against women. It examines how sexual violence is gendered, in Augustine's response, in the adjudication of the case and in the behaviours and expectations of both victim and perpetrator. Whilst working outwards from absence and silence is a central historiographical approach to gender and violence in the past, this article reaches new understandings by turning towards evidence that is usually siloed and working it back into a framework of sexual violence in Augustine's letters.
Polarised random -SAT
Authors: Danielsson Joel Larsson , Markström Klas 
Published: July 2023

AbstractIn this paper we study a variation of the random
$k$
-SAT problem, called polarised random
$k$
-SAT, which contains both the classical random
$k$
-SAT model and the random version of monotone
$k$
-SAT another well-known NP-complete version of SAT. In this model there is a polarisation parameter
$p$
, and in half of the clauses each variable occurs negated with probability
$p$
and pure otherwise, while in the other half the probabilities are interchanged. For
$p=1/2$
we get the classical random
$k$
-SAT model, and at the other extreme we have the fully polarised model where
$p=0$
, or 1. Here there are only two types of clauses: clauses where all
$k$
variables occur pure, and clauses where all
$k$
variables occur negated. That is, for
$p=0$
, and
$p=1$
, we get an instance of random monotone
$k$
-SAT.We show that the threshold of satisfiability does not decrease as
$p$
moves away from
$\frac{1}{2}$
and thus that the satisfiability threshold for polarised random
$k$
-SAT with
$p\neq \frac{1}{2}$
is an upper bound on the threshold for random
$k$
-SAT. Hence the satisfiability threshold for random monotone
$k$
-SAT is at least as large as for random
$k$
-SAT, and we conjecture that asymptotically, for a fixed
$k$
, the two thresholds coincide.
How Communicating Vaccine Benefits and Harms in Fact Boxes Affects	Risk Perceptions
Authors: Felgendreff Lisa , Renkewitz Frank , Betsch Cornelia 
Published: July 2023

Abstract: Background: A fact box is a promising tool for benefit-risk communication. This compact table summarizes the benefits and harms of a health-related intervention and compares the intervention to a control group. Although previous research has demonstrated that fact boxes are well understood, little is known about how they affect risk perceptions. Risk perception is particularly relevant to vaccination behavior. Aims: Two experiments investigated how different profiles of vaccine benefits and harms influence risk perceptions and the intention to vaccinate. Method: In Experiment 1, 430 participants were included in a 4 (benefits [vaccine effectiveness]) × 2 (harms [probability of vaccine adverse events]) between-subjects design. In Experiment 2, 541 participants were included in a 2 (benefits) × 2 (harms) × 2 (comprehension test conducted before or after assessment of risk perceptions) between-subjects design. Measures: Perceived risk of vaccination, intention to vaccinate, comprehension, and, in Experiment 2 only, perceived risk of non-vaccination. Results: Greater benefits decreased the perceived risk of vaccination and increased the intention to vaccinate. More harms increased the perceived risk of vaccination and, in Experiment 2 only, decreased the intention to vaccinate. More benefits increased the perceived risk of non-vaccination. Exploratory analyses showed that the comprehension and position of a comprehension test influenced risk perceptions. Limitations: The experiments used MTurk convenience samples and a fictitious disease. Conclusion: Communicating vaccine profiles in fact boxes affects risk perceptions. Additional measures may cue a deeper elaboration of the vaccine profile.
Coherent control of light-induced torque on four-level tripod atom systems
Authors: Mehdinejad Ali 
Published: July 2023

AbstractThis paper investigates the manipulation of induced torque on a four-level tripod atom system through the interaction with two vortex probe beams featuring spatial inhomogeneity, along with a non-vortex control beam. The study explores both the linear and nonlinear regimes of torque induction. In the linear regime, where the intensity of the vortex beams is weaker than that of the control field, effective control over the induced torque is demonstrated by adjusting parameters such as magnetic field strength, control field intensity, detuning, and dephasing terms between relevant atomic levels. The analysis highlights the significant contribution of the Zeeman shift-induced magnetic field, which enhances the torque and exhibits a distinct sharp peak. Furthermore, higher-order contributions to the induced torque are discussed as the intensity of the probe fields approaches that of the control field, resulting in further enhancement of the induced torque. These findings offer opportunities for precise control over the rotational motion of atoms within the system, with potential applications in precision measurement, quantum information processing, and quantum control.