bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid intensification of suicide risk preceding suicidal behavior among primary care patients
Authors: Bryan Craig J. , Allen Michael H. , Wastler Heather M. , Bryan AnnaBelle O. , Baker Justin C. , May Alexis M. , Thomsen Cynthia J. 
Published: March 2023

AbstractBackgroundApproximately half of those who attempt suicide report experiencing suicidal ideation and suicidal planning in advance; others deny these experiences. Some researchers have hypothesized that rapid intensification is due to past suicidal ideation and/or behaviors that are “mentally shelved” but remain available for rapid access later.MethodTo evaluate this hypothesis, we examined (a) temporal sequencing of suicidal ideation, suicidal planning, and suicidal behavior, and (b) speed of emergence of suicidal behavior in a prospective cohort study of 2744 primary care patients.ResultsOf 52 patients reporting suicidal behavior during follow‐up, 20 (38.5%) reported suicidal ideation and planning prior to their suicidal behavior, 23 (44.2%) reported suicidal ideation but not planning, and nine (17.3%) denied both suicidal ideation and planning. Over half (n = 30, 57.7%) reported the onset of suicidal ideation and/or planning on the same day as or after their suicidal behavior (i.e., rapid intensification). Rapid intensification was not associated with increased likelihood of reporting recent or past suicidal ideation, planning, or behaviors, suggesting rapid intensification does not depend on prior experience with suicidal ideation and/or behaviors.ConclusionDetecting primary care patients at risk for this form of suicidal behavior may be limited even with universal suicide risk screening.
A retrospective evaluation of hops ingestion in 177 dogs (2005–2018)
Authors: Becker Jami , Brutlag Ahna G. , Hovda Lynn , Rendahl Aaron , Tart Kelly M. 
Published: March 2023

AbstractObjectiveTo describe the clinical signs and outcomes observed afterHumulus lupulus(hops) ingestion in dogs. A secondary objective was to note any trends in the number of hops‐related phone calls made to an animal poison control center over a 13‐year period.DesignRetrospective study (2005–2018).SettingAn animal poison control center.AnimalsOne hundred and seventy‐seven dogs with known or suspected hops ingestion.InterventionsNone.Measurements and Main ResultsA total of 177 calls were made to Pet Poison Helpline between 2005 and 2018 involving hops ingestion in dogs. Outcomes were determined in 83 cases; 79 of 83 (95.2%) survived. Clinical signs associated with hops ingestion were observed in 74.0% (131/177). Commonly observed clinical signs were tachypnea (98/131), hyperthermia (65/131), and vomiting (44/131). Severe hyperthermia (>41.4°C, [>106°F]) developed in 8 dogs and 3 of those dogs did not survive. A fourth nonsurvivor was found deceased at home. The majority of symptomatic dogs developed clinical signs between 2 and 8 hours postingestion. Resolution of clinical signs occurred in less than 24 hours in all survivors except in one. Cases consulted with Pet Poison Helpline related to hops ingestion increased from 2005 to 2018 relative to the total amount of cases managed overall.ConclusionsThe most common clinical signs associated with hops ingestion include tachypnea, hyperthermia, and vomiting; however, not all dogs develop clinical signs. While prognosis is good with 95.2% of dogs in this population surviving, some dogs can develop a severe and fatal hyperthermia.
Evaluation and Validation of Microscale Atmospheric Modeling With Offline Weather Research and Forecasting Model to Parallelized Large-Eddy Simulation Model Forcing Conditions
Authors: Dey Shuv , Mallen Evan , Stone Brian , Joshi Yogendra 
Published: March 2023

AbstractAs the rate of urbanization increases, local vegetation is being replaced with man-made materials, causing increasingly adverse impacts on the surface-atmosphere energy balance. These negative effects can be simulated by modeling the urban landscapes in question; however, the main challenges of modeling urban thermal environments are the scale and resolution at which to perform such tasks. Current modeling of urban thermal environments is typically limited to either mesoscale (1 –2000 km) or microscale (&lt;1 km) phenomena. In the present work, an open-source framework for one-way upstream coupled multiscale urban thermal environment simulations is examined and validated. This coupled simulation can provide valuable insights into the flow behavior and energy transport between mesoscale and microscale interactions. The mesoscale to microscale boundary conditions are coupled together using simulated data from the advanced research weather research and forecasting model (WRF-ARW), a mesoscale numerical weather prediction software, and assimilating it into parallelized large-eddy simulation model (PALM), a computational fluid dynamics style (CFD-style) software designed for microscale atmospheric and oceanic flows. The multiscale urban thermal environment simulations are tested for grid sensitivity to variations in model input and control parameters, and then experimentally validated against distributed sensor measurements at the Georgia Institute of Technology (Georgia Tech) campus in Atlanta, GA. Validated microscale atmospheric models with heterogeneous domains can be used to project the thermal benefits of urban heat mitigation strategies (increase use of high-albedo surfaces, tree and vegetation cover, and smart growth practices) and advise building energy usage modeling and policies.
Health engagement: a systematic review of tools modifiable for use with vulnerable pregnant women
Authors: Allen Jyai , Creedy Debra K , Mills Kyly , Gamble Jenny 
Published: March 2023

ObjectiveTo examine available health engagement tools suitable to, or modifiable for, vulnerable pregnant populations.DesignSystematic review.Eligibility criteriaOriginal studies of tool development and validation related to health engagement, with abstract available in English, published between 2000 and 2022, sampling people receiving outpatient healthcare including pregnant women.Data sourcesCINAHL Complete, Medline, EMBASE and PubMed were searched in April 2022.Risk of biasStudy quality was independently assessed by two reviewers using an adapted COSMIN risk of bias quality appraisal checklist. Tools were also mapped against the Synergistic Health Engagement model, which centres on women’s buy-in to maternity care.Included studiesNineteen studies were included from Canada, Germany, Italy, the Netherlands, Sweden, the UK and the USA. Four tools were used with pregnant populations, two tools with vulnerable non-pregnant populations, six tools measured patient–provider relationship, four measured patient activation, and three tools measured both relationship and activation.ResultsTools that measured engagement in maternity care assessed some of the following constructs: communication or information sharing, woman-centred care, health guidance, shared decision-making, sufficient time, availability, provider attributes, discriminatory or respectful care. None of the maternity engagement tools assessed the key construct of buy-in. While non-maternity health engagement tools measured some elements of buy-in (self-care, feeling hopeful about treatment), other elements (disclosing risks to healthcare providers and acting on health advice), which are significant for vulnerable populations, were rarely measured.Conclusions and implicationsHealth engagement is hypothesised as the mechanism by which midwifery-led care reduces the risk of perinatal morbidity for vulnerable women. To test this hypothesis, a new assessment tool is required that addresses all the relevant constructs of the Synergistic Health Engagement model, developed for and psychometrically assessed in the target group.PROSPERO registration numberCRD42020214102.
Barriers and facilitators influencing parent–adolescent communication on sexual and reproductive health in Indigenous communities in Latin American countries: protocol for a scoping review
Authors: Chaparro Buitrago Diana Carolina , Pimentel Juan 
Published: March 2023

IntroductionDespite the global efforts to promote adolescent sexual and reproductive health (SRH), many doubts remain on how to ensure universal health access for this population. Many obstacles prevent adolescents from accessing SRH information and services. As a result, adolescents are disproportionally affected by adverse SRH outcomes. Indigenous adolescents are more likely to receive insufficient information and health services due to poverty, discrimination and social exclusion. This situation is compounded by parents’ limited access to information and the possibility of sharing this information with younger generations. The literature shows that parents play a crucial role in informing adolescents about SRH, but the evidence remains scarce for Indigenous adolescents in Latin America. We aim to discuss the barriers and facilitators of parent–adolescent communication on SRH for Indigenous adolescents in Latin American countries.Methods and analysisA scoping review will follow the Arksey and O’Malley’s framework and the Joanna Briggs Institute Manual. We will include articles published between January 2000 and February 2023 in English and Spanish from seven electronic databases and retrieved references from selected articles. Two independent researchers will screen the articles, excluding duplicates, and extract the data based on the inclusion criteria using a data extraction template. The data will be analysed using a thematic analysis approach. Results will be presented following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) extension for Scoping Reviews checklist and using the PRISMA flow chart, tables and a summary of the key findings.Ethics and disseminationNo ethical approval is needed to conduct a scoping review considering the data will be retrieved from previous publicly published studies. The results of the scoping review will be disseminated in a peer-reviewed journal and conferences targeting researchers, programme developers and policymakers that have experience working in the Americas.Trial registration numberhttps://doi.org/10.17605/OSF.IO/PFSDC.
Role of computed tomography cardiac angiography in acute chest pain syndromes
Authors: Greer Charlotte , Williams Michelle C , Newby David E , Adamson Philip D 
Published: March 2023

Use of CT coronary angiography (CTCA) to evaluate chest pain has rapidly increased over the recent years. While its utility in the diagnosis of coronary artery disease in stable chest pain syndromes is clear and is strongly endorsed by international guidelines, the role of CTCA in the acute setting is less certain. In the low-risk setting, CTCA has been shown to be accurate, safe and efficient but inherent low rates of adverse events in this population and the advent of high-sensitivity troponin testing have left little room for CTCA to show any short-term clinical benefit.In higher-risk populations, CTCA has potential to fulfil a gatekeeper role to invasive angiography. The high negative predictive value of CTCA is maintained while also identifying non-obstructive coronary disease and alternative diagnoses in the substantial group of patients presenting with chest pain who do not have type 1 myocardial infarction. For those with obstructive coronary disease, CTCA provides accurate assessment of stenosis severity, characterisation of high-risk plaque and findings associated with perivascular inflammation. This may allow more appropriate selection of patients to proceed to invasive management with no disadvantage in outcomes and can provide a more comprehensive risk stratification to guide both acute and long-term management than routine invasive angiography.
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy
Authors: van Elsas Marit J , Labrie Camilla , Etzerodt Anders , Charoentong Pornpimol , van Stigt Thans Jordi J C , Van Hall Thorbald , van der Burg Sjoerd H 
Published: March 2023

BackgroundPrimary and secondary resistance is a major hurdle in cancer immunotherapy. Therefore, a better understanding of the underlying mechanisms involved in immunotherapy resistance is of pivotal importance to improve therapy outcome.MethodHere, two mouse models with resistance against therapeutic vaccine-induced tumor regression were studied. Exploration of the tumor microenvironment by high dimensional flow cytometry in combination with therapeuticin vivosettings allowed for the identification of immunological factors driving immunotherapy resistance.ResultsComparison of the tumor immune infiltrate during early and late regression revealed a change from tumor-rejecting toward tumor-promoting macrophages. In concert, a rapid exhaustion of tumor-infiltrating T cells was observed. Perturbation studies identified a small but discernible CD163himacrophage population, with high expression of several tumor-promoting macrophage markers and a functional anti-inflammatory transcriptome profile, but not other macrophages, to be responsible. In-depth analyses revealed that they localize at the tumor invasive margins and are more resistant to Csf1r inhibition when compared with other macrophages.In vivostudies validated the activity of heme oxygenase-1 as an underlying mechanism of immunotherapy resistance. The transcriptomic profile of CD163himacrophages is highly similar to a human monocyte/macrophage population, indicating that they represent a target to improve immunotherapy efficacy.ConclusionsIn this study, a small population of CD163hitissue-resident macrophages is identified to be responsible for primary and secondary resistance against T-cell-based immunotherapies. While these CD163hiM2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.
Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors
Authors: Lontos Konstantinos , Wang Yiyang , Joshi Supriya K , Frisch Andrew T , Watson McLane J , Kumar Alok , Menk Ashley V , Wang Yupeng , Cumberland Rachel , Lohmueller Jason , Carrizosa Esteban , Boyerinas Benjamin , Delgoffe Greg M 
Published: March 2023

BackgroundCellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves genetic engineering to ‘redirect’ peripheral T cells to tumor targets, showing remarkable potency in blood cancers. However, due to several resistance mechanisms, CAR-T cell therapies remain ineffective in solid tumors. We and others have shown the tumor microenvironment harbors a distinct metabolic landscape that produces a barrier to immune cell function. Further, altered differentiation of T cells within tumors induces defects in mitochondrial biogenesis, resulting in severe cell-intrinsic metabolic deficiencies. While we and others have shown murine T cell receptor (TCR)-transgenic cells can be improved through enhanced mitochondrial biogenesis, we sought to determine whether human CAR-T cells could be enabled through a metabolic reprogramming approach.Materials and methodsAnti-EGFR CAR-T cells were infused in NSG mice which bore A549 tumors. The tumor infiltrating lymphocytes were analyzed for exhaustion and metabolic deficiencies. Lentiviruses carrying PPAR-gamma coactivator 1α (PGC-1α), PGC-1αS571Aand NT-PGC-1α constructs were used to co-transduce T cells with anti-EGFR CAR lentiviruses. We performed metabolic analysis via flow cytometry and Seahorse analysis in vitro as well as RNA sequencing. Finally, we treated therapeutically A549-carrying NSG mice with either PGC-1α or NT-PGC-1α anti-EGFR CAR-T cells. We also analyzed the differences in the tumor-infiltrating CAR-T cells when PGC-1α is co-expressed.ResultsHere, in this study, we show that an inhibition resistant, engineered version of PGC-1α, can metabolically reprogram human CAR-T cells. Transcriptomic profiling of PGC-1α-transduced CAR-T cells showed this approach effectively induced mitochondrial biogenesis, but also upregulated programs associated with effector functions. Treatment of immunodeficient animals bearing human solid tumors with these cells resulted in substantially improved in vivo efficacy. In contrast, a truncated version of PGC-1α, NT-PGC-1α, did not improve the in vivo outcomes.ConclusionsOur data further support a role for metabolic reprogramming in immunomodulatory treatments and highlight the utility of genes like PGC-1α as attractive candidates to include in cargo along with chimeric receptors or TCRs for cell therapy of solid tumors.
CDF II W-mass anomaly faces first-order electroweak phase transition
Authors: Addazi Andrea , Marcianò Antonino , Morais António P. , Pasechnik Roman , Yang Hao 
Published: March 2023

AbstractWe suggest an appealing strategy to probe a large class of scenarios beyond the Standard Model simultaneously explaining the recent CDF II measurement of the W boson mass and predicting first-order phase transitions (FOPT) testable in future gravitational-wave (GW) experiments. Our analysis deploys measurements from the GW channels and high energy particle colliders. We discuss this methodology focusing on the specific example provided by an extension of the Standard Model of particle physics that incorporates an additional scalar $$\textrm{SU}(2)_\textrm{L}$$

SU

(
2
)

L

triplet coupled to the Higgs boson. We show that within this scenario a strong electroweak FOPT is naturally realised consistently with the measured W boson mass-shift. Potentially observable GW signatures imply the triplet mass scale to be TeV-ish, consistently with the value preferred by the W mass anomaly. This model can be tested in future space-based interferometers such as LISA, DECIGO, BBO, TianQin, TAIJI projects and in future colliders such as FCC, ILC, CEPC.
In-Hospital Observation on Oral Diuretics After Treatment for Acute Decompensated Heart Failure: Evaluating the Utility
Authors: Ivey-Miranda Juan B. , Rao Veena S. , Cox Zachary L. , Moreno-Villagomez Julieta , Mahoney Devin , Maulion Christopher , Bellumkonda Lavanya , Turner Jeffrey M. , Collins Sean , Wilson F. Perry , Krumholz Harlan M. , Testani Jeffrey M. 
Published: March 2023

Background:
Following treatment for acute decompensated heart failure, in-hospital observation on oral diuretics (OOD) is recommended, assuming it provides actionable information on discharge diuretic dosing and thus reduces readmissions.

Methods:
In the Mechanisms of Diuretic Resistance (MDR) cohort, we analyzed in-hospital measures of diuretic response, provider’s decisions, and diuretic response ≈30 days postdischarge. In a Yale multicenter cohort, we assessed if in-hospital OOD was associated with 30-day readmission risk. The main objective of this study was to evaluate the utility of in-hospital OOD.

Results:

Of the 468 patients in the MDR cohort, 57% (N=265) underwent in-hospital OOD. During the OOD, weight change and net fluid balance correlated poorly with each other (
r
=0.36). Discharge diuretic dosing was similar between patients who had increased, stable, or decreased weight (decreased discharge dose from OOD dose in 77% versus 72% versus 70%, respectively), net fluid status (decreased discharge dose from OOD dose in 100% versus 69% versus 74%, respectively), and urine output (decreased discharge dose from OOD dose in 69% versus 79% versus 72%, respectively) during the 24-hour OOD period (
P
>0.27 for all). In participants returning at 30 days for formal quantification of outpatient diuretic response (n=98), outpatient and inpatient OOD natriuresis was poorly correlated (
r
=0.26). In the Yale multicenter cohort (n=18 454 hospitalizations), OOD occurred in 55% and was not associated with 30-day hospital readmission (hazard ratio, 0.98 [95% CI, 0.93–1.05];
P
=0.51).

Conclusions:
In-hospital OOD did not provide actionable information on diuretic response, was not associated with outpatient dose selection, did not predict subsequent outpatient diuretic response, and was not associated with lower readmission rate. Additional research is needed to replicate these findings and understand if these resources could be better allocated elsewhere.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02546583.
Revolutions and Democracy
Authors: Ustyuzhanin Vadim , Korotayev Andrey 
Published: March 2023

Abstract
In recent years, the question of what form a revolutionary uprising will take – armed or unarmed – has been raised more often. This is because, as shown by numerous studies, revolutionary nonviolence can explain why an uprising fails or succeeds to lead to democracy. In the recent decades the likelihood of revolution being nonviolent appears to have significantly increased, but it is still not clear why this tendency is observed. Moreover, there are only a few quantitative cross-national studies on this topic, in which the authors tried to explain the apparent pattern. However, none of them considered political factors separately. This article tests the hypothesis that a country’s level of democracy can inhibit the armed revolutionary violence. By applying logistic regression to the NAVCO database, the authors analyze more than 400 revolutionary episodes and conclude that, in general, the more democratic the political system, the more likely the revolution take an unarmed form. Nevertheless, various revolutionary events could be of a rather different nature, and it is further shown that the level of democracy matters only for sociopolitical revolutions, while for ethno-separatist revolutions it does not play a significant role.
Bilingual Postgraduates’ Potentials for Original Research by Translanguaging for Theorising
Authors: Shen Haibo 
Published: March 2023

Abstract
Raising the global awareness and mobilising the originality of postgraduate researchers have been emphasized in the internationalisation of postgraduate education in many countries. However, linguistically and theoretically based academic inequalities are still pervasive, which has marginalised non-native English-speaking researchers and their non-English theoretical knowledge systems. Postgraduate researchers in this context tend to depend on Anglo-American and Eurocentric theories which are mostly in English to do research, undermining their possibilities for original research. Bilingual postgraduate researchers, nevertheless, have great potentials for original theorising using translanguaging if a translanguaging perspective is adopted in postgraduate education. By digging into the Chinese word 理论 (lǐ lùn), the paper explains how bilingual postgraduate researchers may be engaged in bilingual theorising with translanguaging and what such theorising capabilities may value. By activating their entire linguistic-theoretical repertoire in this way, bilingual postgraduate researchers, therefore, are able to devise new conceptual and analytical tools to interpret and explain academic issues.