bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of anesthesia modalities on functional outcome of mechanical thrombectomy in patients with acute ischemic stroke: a subgroup analysis of DIRECT-MT trial
Authors: Li Zifu , Ma Hongyu , Li Binben , Zhang Lei , Zhang Yongwei , Xing Pengfei , Zhang Yongxin , Zhang Xiaoxi , Zhou Yu , Huang Qinghai , Li Qiang , Zuo Qiao , Ye Xiaofei , Liu Jianmin , Qureshi Adnan I. , Chen Wenhuo , Yang Pengfei ,   DIRECT-MT Investigators
Published: July 2023

Abstract
Background
This subgroup analysis of Direct Intraarterial Thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals Multicenter Randomized Clinical Trial (DIRECT-MT) aimed to investigate the influence of anesthesia modalities on the outcomes of endovascular treatment.

Methods
Patients were divided into two groups by receiving general anesthesia (GA) or non-general anesthesia (non-GA). The primary outcome was assessed by the between-group difference in the distribution of the modified Rankin Scale (mRS) at 90 days, estimated using the adjusted common odds ratio (acOR) by multivariable ordinal regression. Differences in workflow efficiency, procedural complication, and safety outcomes were analyzed.

Results
Totally 636 patients were enrolled (207 for GA and 429 for non-GA groups). There was no significant shift in the mRS distribution at 90 days between the two groups (acOR, 1.093). The median time from randomization to reperfusion was significantly longer in GA group (116 vs. 93 min, P < 0.0001). Patients in non-GA group were associated with a significantly lower NIHSS score at early stages (24 h, 11 vs 15; 5–7 days or discharge, 6.5 vs 10). The rate of severe manipulation-related complication did not differ significantly between GA and non-GA groups (0.97% vs 3.26%; P = 0.08). There are no differences in the rate of mortality and intracranial hemorrhage.

Conclusions
In the subgroup analysis of DIRECT-MT, we found no significant difference in the functional outcome at 90 days between general anesthesia and non-general anesthesia, despite the workflow time being significantly delayed for patients with general anesthesia.
Clinical trail registration clinicaltrials.gov Identifier: NCT03469206.
Impact of County-level health infrastructure on participation in a reform effort to reduce the use of jail for individuals with mental health disorders
Authors: Ramezani Niloofar , Hailemariam Maji , Breno Alex J. , Mackey Benjamin J. , Cuellar Alison Evans , Johnson Jennifer E. , Taxman Faye S. 
Published: July 2023

AbstractBackgroundThe national Stepping Up Initiative has attracted over 500 counties interested in reducing the use of jail for individuals with mental health disorders. This paper identifies socioeconomic, criminal legal, and health care factors that predict the likelihood of counties joining Stepping Up.ResultsAfter performing variable selection, logistic regression models were performed on 3,141 U.S. counties. Counties designated as medically underserved and/or mental health staffing shortage areas were less likely to participate in this initiative. Logistic regression models showed that larger counties (populations over 250,000) with better health care infrastructure, more mental health providers per capita, higher percent of Medicaid funded drug treatment services, and at least one medical school, were more likely to join Stepping Up. These counties had lower per capita jail populations, higher concentration of police resources, and higher pretrial incarceration rate.ConclusionsCounty-level health care delivery factors are major contributors to a county’s likelihood, or willingness, of engaging in Stepping Up reform efforts to reduce jail population with mental health disorders issues. Therefore, improving availability and accessibility of medical and behavioral health care in different communities, may facilitate efforts to address the unnecessary incarceration of individuals with mental health disorders.
Irrational beliefs indirectly predict retirement satisfaction through the conceptualization of retirement: a cross-sectional study in a sample of recent retirees
Authors: Bačová Viera , Halama Peter , Kordačová Jana 
Published: July 2023

Abstract
Background
Although most retirees are satisfied, some do not feel well in retirement. The resource-based dynamic perspective explains retirement dissatisfaction as the lack of resources. This study focused on psychological resources, specifically on the role of rational/irrational beliefs and retirement concepts in retirement satisfaction. While irrational beliefs have many consequences, we know little about their role in retirement experiences, nor do we know about the benefits/harm of retirement concepts for retirement satisfaction. We assumed that not succumbing to irrational beliefs and conceptualizing retirement actively and positively add to psychological resources helping to adjust to retirement and retirement satisfaction. Our objective was to examine whether irrational beliefs and retirement concepts contributed to satisfaction or dissatisfaction in recent retirees.

Methods
200 recent retirees (average retirement time 2.8 years) completed questionnaires containing the Irrational Belief Scale, the Satisfaction with Retirement Scale, and the Retirement Lifestyles Questionnaire, which determines the inclination toward four retirement concepts: Transition to Old Age, New Start, Continuation, and Imposed Disruption. The Pearson correlation coefficients were used to estimate the relationship between irrational beliefs, retirement concepts, and retirement satisfaction. We used a parallel mediation model with multiple mediators in the mediation analysis where irrational beliefs were the independent variable, retirement satisfaction was the dependent variable, and the four retirement concepts were mediators.

Results
We confirmed higher retirement satisfaction in recent retirees who conceptualize retirement as a New Start and Continuation and higher retirement dissatisfaction in those who see retirement as an Imposed Disruption or Transition to Old Age. The general irrational beliefs had a weaker direct impact on retirement satisfaction than the more specific retirement concepts. Inclination to general irrational beliefs appeared only weakly reflected in retirement dissatisfaction. However, a negative view of retirement as an imposed disruption might increase this inclination by intensifying retirement dissatisfaction.

Conclusions
Our results show a negative retirement concept as an imposed disruptive event that amplifies the impact of general irrational beliefs and leads to retirement dissatisfaction in recent retirees. It suggests that using rational-emotive behavior therapy and interventions to change the negative perception of retirement could be effective in increasing retirement satisfaction.
Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies
Authors: Dabiri Hamed , Safarzadeh Kozani Pooria , Habibi Anbouhi Mahdi , Mirzaee Godarzee Mohadeseh , Haddadi Mohammad Hossein , Basiri Mohsen , Ziaei Vahab , Sadeghizadeh Majid , Hajizadeh Saffar Ensiyeh 
Published: July 2023

AbstractChimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptive transfer. Recent progress in CAR-based therapies has led to outstanding clinical success in certain patients with leukemias and lymphomas and offered therapeutic benefits to those resistant to conventional therapies. The universal approach to stable CAR transgene delivery into the T/NK cells is the use of viral particles. Such approaches mediate semi-random transgene insertions spanning the entire genome with a high preference for integration into sites surrounding highly-expressed genes and active loci. Regardless of the variable CAR expression level based on the integration site of the CAR transgene, foreign integrated DNA fragments may affect the neighboring endogenous genes and chromatin structure and potentially change a transduced T/NK cell behavior and function or even favor cellular transformation. In contrast, site-specific integration of CAR constructs using recent genome-editing technologies could overcome the limitations and disadvantages of universal random gene integration. Herein, we explain random and site-specific integration of CAR transgenes in CAR-T/NK cell therapies. Also, we tend to summarize the methods for site-specific integration as well as the clinical outcomes of certain gene disruptions or enhancements due to CAR transgene integration. Also, the advantages and limitations of using site-specific integration methods are discussed in this review. Ultimately, we will introduce the genomic safe harbor (GSH) standards and suggest some appropriate safety prospects for CAR integration in CAR-T/NK cell therapies.
Fostering computational thinking through unplugged activities: A systematic literature review and meta-analysis
Authors: Chen Peng , Yang Dong , Metwally Ahmed Hosny Saleh , Lavonen Jari , Wang Xiao 
Published: July 2023

AbstractUnplugged activities as a low-cost solution to foster computational thinking (CT) skills seem to be a trend in recent years. However, current evidence of the effectiveness of unplugged activities in promoting students’ CT skills has been inconsistent. To understand the potential of unplugged activities on computational thinking skills, a systematic review and meta-analysis were conducted. Our review of 49 studies examined the influence of unplugged activities to improve students’ CT skills in K–12 education between 2006 and 2022. The literature review showed that studies on CT skills were mainly (81.64%) conducted in computer science and STEM education, with board and card games being the most common unplugged activities for fostering CT skills in K–12 education. CT diagnostic tools (36.37%) were frequently used as assessment tools. A follow-up meta-analysis of 13 studies with 16 effect sizes showed a generally large overall effect size (Hedges’s g = 1.028, 95% CI [0.641, 1.415], p < 0.001) for the use of unplugged activities in promoting students’ CT skills. The analysis of several moderator variables (i.e., grade level, class size, intervention duration, and learning tools) and their possible effects on CT skills indicated that unplugged activities are a promising instructional strategy for enhancing students’ CT skills. Taken together, the results highlight the affordances of unplugged pedagogy for promoting CT skills in K–12 education. Recommendations for policies, practice, and research are provided accordingly.
Latissimus dorsi musculocutaneous flap grafting to the infected recipient site in a patient with irradiated locally advanced breast cancer and multiple lung metastases
Authors: Ishii Yuki , Matsuki Hitomi , Uozumi Nozomi , Oura Shoji 
Published: July 2023

Abstract
Background
Musculocutaneous (MC) flaps are more resistant to infection than implants, but no clinical results have been reported so far about the grafting of MC flap to the overtly infected sites.

Case presentation
A 66-year-old woman had received radiotherapy, a total dose of 50 Gy, to her large mucinous breast cancer to control bleeding from the tumor and was referred to our hospital for further treatment. On her first visit to our hospital, her left breast showed radiation-induced total necrosis with Pseudomonasaeruginosa infection. Removal of the necrotic breast tissue resulted in direct exposure of the left ribs and intercostal muscles with intractable chest pain requiring analgesics. The presence of concomitant life-threatening multiple lung metastases made us change the treatment from letrozole and palbociclib to bevacizumab and paclitaxel, leading to marked regression of the lung metastases. To alleviate her chest pain and get local wound healing, we treated the patient with latissimus dorsi (LD)-MC flap grafting to the exposed chest wall after four months of taxane-containing chemotherapy. The patient has got marked pain relief immediately after the operation. Skin island of the grafted LD-MC flap showed no problems for 4 days just after the operation but gradually turned out to be edematous to ill-colored in the distal part of the skin island. Post-operative clinical outcome suggested that Pseudomonasaeruginosa infection might have had some adverse effect, e.g., microemboli, on MC flap blood flow. Partial necrosis of the LD-MC flap made the patient receive conservative wound management for a very long period of 11 months, finally leading to complete wound healing. After palliative surgery, the patient has been receiving fulvestrant and palbociclib for 14 months and doing well with good control of multiple lung metastases.

Conclusions
Breast surgical oncologists should note that partial flap necrosis can occur when a LD-MC flap is grafted to the infected recipient site and consider the anti-coagulant therapy just after the operation to avoid the adverse effects of the infection.
Youth engagement in research: exploring training needs of youth with neurodevelopmental disabilities
Authors: Dong Samantha Yimeng , Nguyen Linda , Cross Andrea , Doherty-Kirby Amanda , Geboers Jessica , McCauley Dayle , Soper Alice Kelen , St. Dennis Amanda , Steeves Danny , Trehan Natasha , Gorter Jan Willem 
Published: July 2023

Abstract
Background
Authentic researcher-youth partnerships in patient-oriented research (POR) where the research responds to the needs expressed by youth themselves are essential to make research meaningful. While patient-oriented research (POR) is increasingly practiced, few training programs exist in Canada and none, to our knowledge, are tailored for youth with neurodevelopmental disabilities (NDD). Our primary objective was to explore the training needs of youth (ages 18–25) with NDD to enhance their knowledge, confidence, and skills as research partners. Our secondary objective was to identify the benefits and challenges of engaging youth with NDD in a POR approach.

Methods
Our team of four youth and one parent with lived experience [Youth Engagement in Research (YER) partners] and six researchers engaged in POR to investigate the primary objective via two phases: (1) individual interviews with youth living with NDD and (2) a two-day virtual symposium with focus groups with youth and researchers. Collaborative qualitative content analysis was employed to synthesize the data. Our secondary objective was assessed by asking our YER partners to complete the Public and Patient Engagement Evaluation Tool (PPEET) survey and participate in reflective discussions.

Results
Phase 1 participants (n = 7) identified various barriers and facilitators to their engagement in research and offered suggestions to meet their needs through minimizing barriers and integrating facilitators, which would subsequently enhance their knowledge, confidence, and skills as research partners. Informed by phase 1, phase 2 participants (n = 17) prioritized the following POR training needs: researcher-youth communication, research roles and responsibilities, and finding partnership opportunities. For delivery methods, participants stated the importance of youth representation, using Universal Design for Learning, and co-learning between youth and researchers. Based on the PPEET data and subsequent discussions, YER partners agreed that they were able to express views freely, feel that their views were heard, and that their participation made a meaningful difference. Challenges included scheduling difficulties, ensuring multiple methods for engagement, and working under short timelines.

Conclusion
This study identified important training needs for youth with NDD and for researchers to engage in meaningful POR, which can subsequently inform the co-production of accessible training opportunities with and for youth.
Prosocial behaviour axioms and values: Influence of gender and volunteering
Authors: Olmos-Gómez María del Carmen , Ruiz-Garzón Francisca , Azancot-Chocron David , López-Cordero Rafael 
Published: July 2023

AbstractTo promote prosocial behaviour, in the present study, we observed the human values that may predict it within the realms of the transcendental views of life, society’s shared culture and the world of personal and interpersonal affections. To do this, we started with two hypotheses: (1) prosocial behaviour differs according to gender and participation in volunteering; and (2) the variables of transcendental values, cultural development, affective development, gender and participation in volunteering predict prosocial behaviour.To do so, we conducted a quantitative study based on the cross-sectional, social analytical-empirical research method. We used a validated instrument with a large sample of 1,712 individuals living in the multicultural context of the Spanish city of Melilla, located in North Africa and one of only two land borders between Europe and Morocco. Values that could promote prosocial behaviour were grouped into four dimensions to locate relevant factors that helped identify which values are linked to specific actions, both formal and informal, through an inferential analysis focusing on regression and multivariate analysis of variance.Our findings highlighted the linkage of the transcendent dimension of the individual in relation to his or her level of prosocial behaviour and the role of women as socialising agents.
Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review
Authors: Ogura Takehisa , Katagiri Takaharu , Kameda Hideto 
Published: July 2023

Abstract
Background
This study aimed to provide an overview of ultrasonographic cartilage evaluation in patients with rheumatoid arthritis (RA) and identify research gaps in the utilization of cartilage evaluation.

Methods
The study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines. A systematic literature search of the PubMed, Embase, and Cochrane Library databases was conducted for articles published up to July 2022 using the search term variations of “cartilage,” “ultrasonography,” and “rheumatoid arthritis.” Studies that included patients with RA who underwent cartilage evaluation by ultrasonography were selected. Articles published in languages other than English and about juvenile idiopathic arthritis were excluded.

Results
Twenty-nine articles were identified. Most were cross-sectional studies (86%), mainly involving the metacarpophalangeal (55%) and knee (34%) joints. Assessments were performed using quantitative, binary, and semi-quantitative methods in 15, 10, and 15 studies, respectively. Reliability assessments were conducted in 10 studies, which showed feasible reliability but were limited to the finger joints. The validity assessment was validated in one study each that compared cartilage thickness measurements with cadaveric specimens and histological and semi-quantitative methods with surgical specimens, respectively. Comparisons with conventional radiography were also performed in six studies, which showed significant correlations. However, there was heterogeneity in the examination and assessment methods, and no adequate longitudinal evaluation was conducted.

Conclusion
This review highlights the need for further research and validation of ultrasonographic cartilage assessment in patients with RA.
An alginate-based encapsulation enhances shelf life and bioactivity of the entomopathogenic fungus, Metarhizium anisopliae
Authors: Sarma B. D. , Puzari K. C. , Dutta Pranab , Pandey Abhay K. 
Published: July 2023

Abstract
Background
This study evaluated the shelf life and effectiveness of Metarhizium anisopliae encapsulated in Na (sodium)-alginate matrix. Air-flow-dried and freeze-dried beads containing conidia of M. anisopliae produced in submersion in the liquid broth were fabricated and characterized. Shelf life and efficacy of fabricated beads against three species of the white grubs, namely Holotrichia serrata, Adoretus sp., and Lepidiota mansueta, were evaluated under greenhouse conditions.

Results
The mean size of the wet beads ranged between 1.4 and 3.2 mm. The mean size of beads that were dried through freeze drying ranged between 0.55 and 2.3 mm. However, the mean size of beads dried through air flow ranged between 0.55 and 2.35 mm. Viability of M. anisopliae was more in freeze-dried beads stored at 8 °C compared to air-flow-dried beads with 20.0 × 107 and 16.00 × 107 CFU/g, respectively, after two weeks of drying. Further, freeze-dried beads supported M. anisopliae conidial viability till 10 months with 2.0 × 107 CFU/g. The LC50 values of the freeze-dried beads with M. anisopliae after 21 days of treatment were 0.35 (2.1 × 108 CFU/g), 0.31 (2.1 × 108 CFU/g), and 0.76 mg (2.1 × 108 CFU/g) against H. serrata, Adoretus sp., and L. mansueta, respectively.

Conclusion
The results of this study support the use of Na-alginate beads followed by freeze drying to maintain the viability of M. anisopliae. The effectiveness of freeze-dried beads with M. anisopliae against white grubs indicates that these beads can be an alternative option of synthetic insecticides against soil dwelling insect pests. In addition, this study offers a steppingstone for further advancement of sodium alginate encapsulated formulations for soil insect control.
Unravelling early childhood pre-service teachers’ implicit stereotypes of scientists by using the repertory grid technique
Authors: Yilmaz-Na Elanur , Sönmez Elif 
Published: July 2023

AbstractConsidering teachers’ roles in developing children’s scientific literacy in preschools, a better understanding of pre-service teachers’ conceptualizations about scientific inquiry and scientists’ practices that have an impact on the science teaching practices offered to their future students is very much needed. Stereotypes were examined here as a component or root for many of the explanations for pre-service teachers’ conceptualizations about scientists. Aligned with the interpretivist paradigm, this phenomenographic study was, mostly qualitative in nature, specifically concerned with exploring pre-service teachers’ stereotypes of scientists by using the repertory grid technique, in which they perceived and differentiated between scientists. 119 early childhood pre-service teachers were recruited. Various types of analysis were carried out to analyze the data gathered in each repertory grid. We investigated the original 66 elicited bipolar constructs into 28 aggregated bi-polar construct groupings, systematically categorized into four bi-polar categories: (1) Recognition vs. Disregarded, (2) Scientific Integrity vs. Misconduct, (3) Communal vs. Dissociation, and (4) Agentic vs. Passivity. The findings suggest that pre-service teachers had typical stereotypical traits of scientists like being introverted, intelligent loners, into experiments and masters in their field with often-unrecognizable female figures. However, there was no association between gender, grade, and stereotypes of scientists elicited in the study. These types of stereotypes of scientists might potentially threaten effective science teaching at early ages. Science education practices can be rooted in these stereotypes of pre-service teachers. Considering these findings, structural changes in science education practices in teacher education programs are very much needed. This study also seems to confirm the importance of using the repertory grid technique as a good starting point to expose especially the implicit stereotypes of pre-service teachers about “who does science”, “how scientists think” and “what scientists do” before their actual actions in future classrooms.