bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studying the Incidence of Nausea and Vomiting after General Anesthesia and Determining the Risk Factors
Authors: Saker Kenan Ahmad , alasiry Mohamad jamal mohamad zien , Fawares Maamoun Ayman AL- , Rekmani Najwa Fajr 
Published: August 2023

Abstract

Background and Aim: Postoperative Nausea and Vomiting (PONV) is a common problem that concerns both anesthesiologists and surgical patients. This study aims to study the incidence of nausea and vomiting after general anesthesia and to determine the risk factors.
Methods and material: The study included 250 patients who were admitted to Damascus Hospital affiliated to the Ministry of Health and Tishreen Military Hospital affiliated to the Ministry of Defense in the departments of surgery in various departments, and who met admission and exclusion criteria, the type of study was descriptive and cross sectional, and it was conducted between 1/7/2023 and 10/8/2023.
Results: The average age of patients was (37.768 ± 17.2 years), and the ages ranged between (5 years and 83 years), and according to sex (58% males, 42% females), and the average surgical work for patients was (95.34 ± 64.467 minutes), and the duration ranged between (15 and 390 minutes), and the percentage of non-smokers was (56.4%). The most operations performed in the two hospitals were (laparoscopic cholecystectomy) (10.4%), followed by discectomy operations (5.6%). (Propofol) was used (45.6%). 54.4%) (Atracurium) (54.4%) was used, Esmeron (45.6%) was used, (Isoflurane, Sevoflural, Halothane) were used (52.8%, 1.6%, 45.6%, respectively), (Prostigmine, Fentanyl) were used, marcaine) (0.8%, 98.4%, 0.8%, respectively), the average pain level was the highest (45.2%), and the percentage of nausea, vomiting, and motion sickness was (53.2%, 55.6%, respectively).
conclusion: The method of anesthesia and anesthetics used have an important and significant role in the occurrence of nausea and vomiting, as modern anesthesia methods and the use of advanced anesthesia devices with what has been manufactured in the past ten years of modern anesthetics such as propofol and Sevoflurane and others have all contributed to reducing the incidence of nausea and vomiting in a small way after work Surgical and anesthesia.
From Counterportation to Local Wormholes
Authors: Salih Hatim 
Published: August 2023

Abstract
We propose an experimental realisation of the protocol for the counterfactual
disembodied transport of an unknown qubit—or what we call counterportation—
where sender and receiver, remarkably, exchange no particles. We employ
cavity quantum electrodynamics, estimating resources for beating the classical
fidelity limit—except, unlike teleportation, no preshared entanglement
nor classical communication are required. Our approach is multiple orders
of magnitude more efficient in terms of physical resources than previously
proposed implementation, paving the way for a demonstration using existing
imperfect devices. Surprisingly, while such communication is intuitively explained
in terms of “interaction-free” measurement and the Zeno effect, we
show that neither is necessary, with far-reaching implications in support of an
underlying physical reality. We go on to characterise an explanatory framework
for counterportation starting from constructor theory: local wormholes.
Conversely, a counterportation experiment demonstrating the traversability of
space, by means of what is essentially a 2-qubit exchange-free quantum computer,
can point to the existence in the lab of such traversable wormholes.
A machine learning approach to discrimination of igneous rocks and ore deposits by zircon trace elements
Authors: Wen Zi-Hao , Li Lin , Kirkland Christopher L. , Li Sheng-Rong , Sun Xiao-Jie , Lei Jia-Li , Xu Bo , Hou Zeng-Qian 
Published: August 2023

Abstract
The mineral zircon has a robust crystal structure, preserving a wealth of geological information through deep time. Traditionally, trace elements in magmatic and hydrothermal zircon have been employed to distinguish between different primary igneous or metallogenic growth fluids. However, classical approaches based on mineral geochemistry are not only time consuming but often ambiguous due to apparent compositional overlap for different growth environments. Here, we report a compilation of 11 004 zircon trace element measurements from 280 published articles, 7173 from crystals in igneous rocks, and 3831 from ore deposits. Geochemical variables include Hf, Th, U, Y, Ti, Nb, Ta, and the REEs. Igneous rock types include kimberlite, carbonatite, gabbro, basalt, andesite, diorite, granodiorite, dacite, granite, rhyolite, and pegmatite. Ore types include porphyry Cu-Au-Mo, skarn-type polymetallic, intrusion-related Au, skarn-type Fe-Cu, and Nb-Ta deposits. We develop Decision Tree, XGBoost, and Random Forest algorithms with this zircon geochemical information to predict lithology or deposit type. The F1-score indicates that the Random Forest algorithm has the best predictive performance for the classification of both lithology and deposit type. The eight most important zircon elements from the igneous rock (Hf, Nb, Ta, Th, U, Eu, Ti, Lu) and ore deposit (Y, Eu, Hf, U, Ce, Ti, Th, Lu) classification models, yielded reliable F1-scores of 0.919 and 0.891, respectively. We present a web page portal (http://60.205.170.161:8001/) for the classifier and employ it to a case study of Archean igneous rocks in Western Australia and ore deposits in Southwest China. The machine learning classifier successfully determines the known primary lithology of the samples, demonstrating significant promise as a classification tool where host rock and ore deposit types are unknown.
Pyrite stability and chalcophile element mobility in a hot Eocene forearc of the Pacific Rim Terrane, Vancouver Island, Canada
Authors: Geen Alexander C. , Canil Dante 
Published: August 2023

Abstract
The conditions of pyrite (Py) stability inform the extent of S mobility during prograde metamorphism, the formation of orogenic Au deposits, and the S cycle in subduction zones. The variables that affect Py stability and chalcophile element mobility are investigated in the Pacific Rim Terrane of Vancouver Island, Canada, where sulfide-bearing carbonaceous sediments have been metamorphosed from 230 to 600 °C and 4 kbar by mid-ocean ridge subduction in a hot fore arc setting during the Eocene. The petrographic evidence in the rocks shows Py can coexist with pyrrhotite (Po) over a wide temperature window to &gt;550 °C as preserved in porphyroblasts of andalusite, staurolite, and garnet. Conversely, equilibrium phase diagrams constructed for the rock compositions conflict with observations and suggest the breakdown of primary Py occurs over a narrow temperature range below 400 °C. The phase diagrams are consistent with the coexistence of Py and Po up to lower amphibolite facies only if S locally comprises a much greater proportion involved in a reaction than that of the overall bulk-rock composition used in the calculations. While the chemistry of the bulk rocks and Po included in porphyroblasts show mobilization of H2O and S with increasing metamorphic grade of the forearc, this process appears unrelated to the distribution of chalcophile elements or Au deposits found in the Pacific Rim Terrane.
Influence of Fe(II), Fe(III), and Al(III) isomorphic substitutions on acid-base properties of edge surfaces of cis-vacant montmorillonite: Insights from first-principles molecular dynamics simulations and surface complexation modeling
Authors: Gao Pengyuan , Liu Xiandong , Guo Zhijun , Tournassat Christophe 
Published: August 2023

Abstract
Knowing the influence of isomorphic substitutions on the acid-base properties of smectite edge surfaces is an important aspect of the detailed understanding of clay minerals’ interfacial properties with implications in the modeling of adsorption processes. We investigated the intrinsic acidity constants of Fe(II)/Fe(III) and Al(III) substituted edge surface sites of montmorillonite with a cis-vacant structure, which includes four crystallographic orientations perpendicular to [010], [010], [110], and [110], using the first-principles molecular dynamics (FPMD) based vertical energy gap method. Fe(II) and Fe(III) substitutions resulted, respectively, in a significant increase and decrease in pKa values of amphoteric groups directly associated with Fe octahedra. In addition, Fe(II) substitution increased the pKa values of the neighboring silanol sites, while Fe(III) substitution had a weak influence on these sites. The Al-substituted tetrahedra had amphoteric sites with higher pKa values than the non-substituted Si tetrahedra, and they increased significantly the pKa values of the sites bridging the tetrahedral and octahedral sheets on surfaces perpendicular to [010] and [110]. The acid-base properties of substituted and non-substituted surface sites of cis-vacant montmorillonite were used to build a state-of-the-art surface complexation model, which successfully reproduced the best available experimental acid-base titration data. This model was further used to predict acid-base properties of dioctahedral smectites (montmorillonite, beidellite, and nontronite) according to their cis- or trans-vacant structures and their layer chemistry. According to these predictions, these smectites exhibit very similar overall pH buffering properties despite significant differences in structure and chemistry. A detailed analysis of the acid-base properties as a function of crystallographic directions demonstrated, however, that these differences should have a large influence on the adsorption of ionic species.
Silencing TRIM29 Sensitizes Non-small Cell Lung Cancer Cells to
Anlotinib by Promoting Apoptosis via Binding RAD50
Authors: Wu Min , Jin Meng-Meng , Cao Xiao-Hui , Zhao Lei , Li Yong-Huai 
Published: August 2023

Background:
Previous studies have proposed that the transcriptional regulatory factor
tripartite motif containing 29 (TRIM29) is involved in carcinogenesis via binding with nucleic
acid. TRIM29 is confirmed to be highly expressed when the cancer cells acquire therapy-resistant
properties. We noticed that TRIM29 levels were significantly increased in anlotinib-resistant NCIH1975
(NCI-H1975/AR) cells via mining data information from gene expression omnibus (GEO)
gene microarray (GSE142031; log2 fold change > 1, p <0.05).

Objective:
Our study aimed to investigate the function of TRIM29 on the resistance to anlotinib in
non-small cell lung cancer (NSCLC) cells, including NCI-H1975 and A549 cells.

Methods:
Real-time RT-PCR and western blot were used to detect TRIM29 expression in anlotinib-
resistant NSCLC (NSCLC/AR) cells. Apoptosis were determined through flow cytometry,
acridine orange/ethidium bromide staining as well as western blot. ELISA was used to measure the
content of C-X3-C motif chemokine ligand 1. Co-Immunoprecipitation assay was performed to verify
the interaction between TRIM29 and RAD50 double-strand break repair protein (RAD50).

Results:
TRIM29 expression was shown to be elevated in the cytoplasm and nucleus of NSCLC/
AR cells compared to normal NSCLC cells. Next, we demonstrated that TRIM29 knockdown facilitated
apoptosis and enhanced the sensitivity to anlotinib in NSCLC/AR cells. Based on the
refined results citing from the database BioGRID, it was proved that TRIM29 interacted with
RAD50. Herein, RAD50 overexpression diminished the pro-apoptotic effect induced by silencing
TRIM29 in anlotinib-resistant A549 (A549/AR) cells.

Conclusion:
Finally, we concluded that the increased sensitivity to anlotinib in NSCLC/AR cells
was achieved by knocking down TRIM29, besides, the positive effects of TRIM29 knockdown
were attributed to the promotion of apoptosis via binding to RAD50 in NSCLC/AR cell nucleus.
Therefore, TRIM29 might become a potential target for overcoming anlotinib resistance in NSCLC
treatment.
Evaluation of Hydrazide-hydrazone and 4-thiazolidinone Derivatives of Etodolac as Potential Anticancer Agents in Leukemia Cells
Authors: Tiber Pinar Mega , Averbek Sera , Sevinç Sevgi Koçyiğit , Kilinç Olca , Süzgün Pelin Çikla , Küçükgüzel S. Güniz , Orun Oya 
Published: August 2023

Background:
Nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used for their anti-inflammatory and analgesic properties, have also been found to prevent cancer. (±)(R,S) Etodolac is an NSAID that belongs to the class of cyclooxygenase-2 inhibitors. Various derivatives of etodolac are synthesized to boost its anti-proliferative action and lessen its potential negative effects. In our earlier studies, some novel derivatives of etodolac exhibited stronger cytotoxic effects on prostate cell lines and had similar effects on leukemia cells in pre-screening experiments.

Objective:
Using the K562 leukemia cell line as a model, we sought to investigate the anti-cancer properties of a hydrazide-hydrozone derivative (SGK-205) and a 4-thiazolidinone derivative of etodolac (SGK-216).

Materials and Methods:
In the current investigation, SGK-205 and SGK-216 compounds were administered to K562 cells for 24 and 48 hours at concentrations of 10, 25, 50, 75 and 100 μM. Cell viability was assessed using the MTT test, and apoptosis by Annexin V-PI staining and mitochondrial membrane potential assays, together with mRNA expressions of apoptotic proteins. The levels of the proteins, HER2 and COX2, were also examined to evaluate COX2 inhibitory capacity.

Results:
In K562 cells, there was a definite dose-dependent response to SGK-205 and SGK-216 compounds. Results from MTT viability tests, together with mitochondrial membrane potential measurements and Annexin V-PI staining, revealed that SGK-216 and SGK-205 significantly outperformed etodolac in terms of their apoptotic and anti-proliferative activities. The concentration range of 10-20 M for both chemicals was sufficient to start biological responses. Apoptosis was also investigated through the expressions of pro- and anti-apoptotic proteins. Additionally, gene expression research demonstrated SGK-205 to be a beneficial substitute to etodolac in lowering COX-2 and human epidermal growth factor receptor-2 (HER2) expression.

Conclusion:
Our data indicated both derivatives to have higher anti-proliferative and apoptotic effects compared to etodolac. An overall assessment highlighting apoptotic induction potential, acceptable toxicity levels, a consistent dose-response relationship, and COX2 inhibitory actions, in particular, indicated SGK-205 as a viable novel therapeutic.
Identification of Pyrroloimidazoles as Potential Inhibitors of WDR5-WIN-Site by 3D-QSAR Molecular Simulation
Authors: Chen Xiao Die , Shi Yuan Ze , Yu Na , Li Jia Li , Wu Jin Ping , Zhao Xue Min , Shu Mao , Lin Zhi Hua 
Published: August 2023

Background:
WD repeat structural domain 5 (WDR5), which plays an important role in various
biological functions through epigenetic regulation, is aberrantly expressed in human cancers, and is
an effective target for the discovery of anticancer drugs.

Methods:
In this paper, QSAR modeling analysis, including comparative molecular field (CoMFA) and
comparative molecular similarity index analysis field (CoMSIA), was first performed using 41 pyrroloimidazole
analogs. The results showed q2=0.667 and r2=0.981 in CoMFA and q2=0.662 and r2=0.983 in
CoMSIA. Molecular docking and molecular dynamics simulations further confirmed the interaction and
binding affinity of the inhibitors with key residues of the proteins, for example, PHE149, PHE133, and
CYS261.

Results:
Based on QSAR and docking studies, seven new compounds with high scores and qualified
ADMET performance were designed.

Conclusion:
In this study, new ideas have been provided for exploring new WDR5 inhibitors.
Trust and Health Information Exchanges: Qualitative Analysis of the Intent to Share Personal Health Information
Authors: Busch-Casler Julia , Radic Marija 
Published: August 2023

Background
Digital health has the potential to improve the quality of care, reduce health care costs, and increase patient satisfaction. Patient acceptance and consent are a prerequisite for effective sharing of personal health information (PHI) through health information exchanges (HIEs). Patients need to form and retain trust in the system(s) they use to leverage the full potential of digital health. Germany is at the forefront of approving digital treatment options with cost coverage through statutory health insurance. However, the German population has a high level of technology skepticism and a low level of trust, providing a good basis to illuminate various facets of eHealth trust formation.

Objective
In a German setting, we aimed to answer the question, How does an individual form a behavioral intent to share PHI with an HIE platform? We discussed trust and informed consent through (1) synthesizing the main influence factor models into a complex model of trust in HIE, (2) providing initial validation of influence factors based on a qualitative study with patient interviews, and (3) developing a model of trust formation for digital health apps.

Methods
We developed a complex model of the formation of trust and the intent to share PHI. We provided initial validation of the influence factors through 20 qualitative, semistructured interviews in the German health care setting and used a deductive coding approach to analyze the data.

Results
We found that German patients show a positive intent to share their PHI with HIEs under certain conditions. These include (perceived) information security and a noncommercial organization as the recipient of the PHI. Technology experience, age, policy and regulation, and a disposition to trust play an important role in an individual’s privacy concern, which, combined with social influence, affects trust formation on a cognitive and emotional level. We found a high level of cognitive trust in health care and noncommercial research institutions but distrust in commercial entities. We further found that in-person interactions with physicians increase trust in digital health apps and PHI sharing. Patients’ emotional trust depends on disposition and social influences. To form their intent to share, patients undergo a privacy calculus. Hereby, the individual’s benefit (eg, convenience), benefits for the individual’s own health, and the benefits for public welfare often outweigh the perceived risks of sharing PHI.

Conclusions
With the higher demand for timely PHI, HIE providers will need to clearly communicate the benefits of their solutions and their information security measures to health care providers (physicians, nursing and administrative staff) and patients and include them as key partners to increase trust. Offering easy access and educational measures as well as the option for specific consent may increase patients’ trust and their intention to share PHI.
User and Usability Testing of a Web-Based Genetics Education Tool for Parkinson Disease: Mixed Methods Study
Authors: Han Noah , Paul Rachel A , Bardakjian Tanya , Kargilis Daniel , Bradbury Angela R , Chen-Plotkin Alice , Tropea Thomas F 
Published: August 2023

Background
Genetic testing is essential to identify research participants for clinical trials enrolling people with Parkinson disease (PD) carrying a variant in the glucocerebrosidase (GBA) or leucine-rich repeat kinase 2 (LRRK2) genes. The limited availability of professionals trained in neurogenetics or genetic counseling is a major barrier to increased testing. Telehealth solutions to increase access to genetics education can help address issues around counselor availability and offer options to patients and family members.

Objective
As an alternative to pretest genetic counseling, we developed a web-based genetics education tool focused on GBA and LRRK2 testing for PD called the Interactive Multimedia Approach to Genetic Counseling to Inform and Educate in Parkinson’s Disease (IMAGINE-PD) and conducted user testing and usability testing. The objective was to conduct user and usability testing to obtain stakeholder feedback to improve IMAGINE-PD.

Methods
Genetic counselors and PD and neurogenetics subject matter experts developed content for IMAGINE-PD specifically focused on GBA and LRRK2 genetic testing. Structured interviews were conducted with 11 movement disorder specialists and 13 patients with PD to evaluate the content of IMAGINE-PD in user testing and with 12 patients with PD to evaluate the usability of a high-fidelity prototype according to the US Department of Health and Human Services Research-Based Web Design & Usability Guidelines. Qualitative data analysis informed changes to create a final version of IMAGINE-PD.

Results
Qualitative data were reviewed by 3 evaluators. Themes were identified from feedback data of movement disorder specialists and patients with PD in user testing in 3 areas: content such as the topics covered, function such as website navigation, and appearance such as pictures and colors. Similarly, qualitative analysis of usability testing feedback identified additional themes in these 3 areas. Key points of feedback were determined by consensus among reviewers considering the importance of the comment and the frequency of similar comments. Refinements were made to IMAGINE-PD based on consensus recommendations by evaluators within each theme at both user testing and usability testing phases to create a final version of IMAGINE-PD.

Conclusions
User testing for content review and usability testing have informed refinements to IMAGINE-PD to develop this focused, genetics education tool for GBA and LRRK2 testing. Comparison of this stakeholder-informed intervention to standard telegenetic counseling approaches is ongoing.
Psychodermatological Disorders in Patients With Primary Psychiatric Conditions: Cross-Sectional Study
Authors: Ajani Atinuke Arinola , Olanrewaju Fatai Olatunde , Oninla Olumayowa Abimbola , Ibigbami Olanrewaju , Mosaku Samuel Kolawole , Onayemi Olaniyi Emmanuel , Olasode Olayinka 
Published: August 2023

Background
Psychodermatological disorders (PDs) and their associations with mental health problems are one of the most frequent research themes in dermatology outpatient settings. Surprisingly, very few studies have been conducted to evaluate PDs among patients with primary psychiatric conditions. As such, the relationship between preexisting psychiatric conditions and comorbid PDs is underrepresented in the literature.

Objective
This study examined the prevalence and distribution of PDs among adults with primary psychiatric conditions and determined their association with underlying psychiatric diagnoses.

Methods
We conducted a cross-sectional analysis at a tertiary health care facility in southwestern Nigeria. Comorbid PDs were identified and classified using preexisting classification systems. A bivariate analysis was conducted to determine the association between PDs and underlying psychiatric conditions. The level of statistical significance was set at P<.05.

Results
The study included 107 patients with mental health disorders, of whom 64 (59.8%) were female. The mean age of the patients was 40.73 (SD 13.08) years. A total of 75 (75/107, 70%) patients had at least one comorbid PD. The prevalence of PDs was highest in patients with affective disorders (15/20, 75%) and least in those with schizophrenia (45/66, 68%). PDs associated with delusions or hallucinations and somatoform symptoms were 9 and 13 times more frequent in patients with anxiety disorders compared to those with other psychiatric conditions (P=.01; odds ratio [OR] 9.88, 95% CI 1.67-58.34 and P=.003; OR 13.13, 95% CI 2.34-73.65), respectively. In contrast, patients with schizophrenia were significantly less likely to be diagnosed with dermatoses resulting from delusions or hallucinations (P=.002; OR 0.04, 95% CI 0.00-0.75). A weak but significant negative association was also found between psychophysiological PDs and anxiety disorders (ϕ=–0.236; P=.02).

Conclusions
This study provides important insights into the overwhelming burden of psychodermatological conditions in patients with mental health disorders and specific associations with underlying psychiatric diagnosis.