bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Predicting Spontaneous Closure of Patent Ductus Arteriosus in Very Low Birth Weight Neonates
Authors: Depala Kiran , Atkinson Helen , Budhani Shaaista , Yitayew Miheret , Mydam Janardhan 
Published: August 2023

Abstract

Background: Management of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) neonates remains a challenge. Accurate prediction of spontaneous PDA closure could allow selective medical treatment and prevent unnecessary medical intervention.
This study aims to evaluate potential variables as predictors of spontaneous closure of hsPDA in VLBW infants.
Methods: We conducted a retrospective review of VLBW infants born from 2006 to 2014 at our institution. Infants included in the study were diagnosed with moderate to large hsPDA on echocardiogram in the first week of life. We divided our population into 2 study groups: PDA closure before discharge without medical/surgical treatment (spontaneous closure) and PDA closure by medical or surgical treatment warranted by critical clinical status. Relevant baseline data and PDA-related parameters were extracted from the medical records. Statistically significant variables were further analyzed using a multiple logistic regression model to identify potential independent predictors of spontaneous closure.
Results: 108 infants were included in the study; 52 had spontaneous PDA closure and 56 required treatments. Of the baseline characteristics, only gestational age and mode of delivery differed significantly between infants with spontaneous closure and those who required treatment. Significant variables included hematocrit and fluids received on day 1 of life, pre-diagnosis mean pH, PCO2, serum bicarbonate, average fluid goal, and average urine output. After multiple logistic regression analysis, controlling for statistically significant and clinically relevant variables, Cesarian section (OR, 0.18, 95% CI, 0.06-0.55; P=.003), average pre-diagnosis PCO2 (OR, 0.92; 95% CI, 0.86-0.98; P=0.008) and pre-diagnosis daily fluid received (OR, 0.96; 95% CI, 0.94-0.99; P=0.03) were independent predictors of spontaneous closure. Sensitivity and specificity analysis of predictor variables revealed highest sensitivity cut-off points of 40 mm Hg (71.2%) for PCO2, 104 mL/kg/d (71.2%) for fluid goal and highest specificity cut-offs of 64 mm Hg (91.1%) and 158 mL/kg/d (96%), respectively.
Conclusion: In our study of VLBW infants, lower average pre-diagnosis CO2, lower daily fluid goal, and vaginal birth were associated with increased likelihood of spontaneous hsPDA closure.
The Kidney Volume-to-Birth Weight Ratio as a Surrogate Indicator for the Number of Nephrons in Extremely Low Birth Weight Preterm Infants
Authors: Villani Gabriele , Zaza Pierluigi , Lamparelli Raffaella , Maffei Gianfranco 
Published: August 2023

Abstract
Background: In humans, nephrogenesis is completed 4-6 weeks after birth. Premature birth interrupts renal development and maturation. In Neonatal Intensive Care Units (NICUs), harmful factors for premature infants increase the risk of hypertension, cardiovascular diseases, and renal failure in adulthood. The aim of this study is to identify preterm infants with a low number of nephrons at birth for appropriate surveillance and targeted care.
Methods: Between March 2018 and March 2021, 29 extremely low birth weight premature infants (ELBW) were enrolled, including 25 appropriate for gestational age (AGA) and 4 small for gestational age (SGA). For each infant, body weight was recorded, and single and combined renal volume, as well as relative renal volume (the ratio of renal volume to body weight), were calculated using ultrasound. These measurements were taken one week after birth and every 2 weeks up to 38-40 weeks post-menstrual age (PMA), as well as at 6, 12, 18, and 24 months of PMA. Pearson's correlation coefficient was used to evaluate the strength of the correlation between renal volume and body weight for each infant.
Results: The Pearson's coefficient showed a strong positive correlation for all infants from one week after birth to 38-40 weeks of PMA and from 38-40 weeks to 24 months of PMA.
Conclusions: The ratio of kidney volume to birth weight appears to be a more reliable indicator for estimating the number of nephrons at birth. The identification of infants with a lower number of nephrons allows for more appropriate follow-up, thereby reducing the risk of developing kidney failure in adulthood.
Clinical efficacy of nucleoplasty for uncontained lumbar disc herniation: A retrospective study
Authors: Choi Yong Cheol , Seo Jong Hun , Kim Pius 
Published: August 2023

Abstract
Background
There are insufficient in-depth studies on whether percutaneous lumbar nucleoplasty (PLN) is effective and safe for the treatment of uncontained lumbar disc herniation (ULDH). This study aimed to investigate the clinical efficacy of PLN on radiating leg pain caused by ULDH.
Methods
Patients who underwent PLN for ULDH and met the inclusion criteria between June 2018 and July 2022 were included. Clinical outcomes were evaluated using the numeric rating scale (NRS) for radiating pain preoperatively; at 1 day, 1 week, and 1 month postoperatively; and at the last follow-up. Patient satisfaction was assessed using MacNab criteria.
Results
Forty-one patients were enrolled. The mean age was 50.2 years (range 24–73 years). The mean and standard deviation of the preoperative NRS in 39 patients with radiating pain was 9.0 ± 1.2. The NRS scores at 1 day, 1 week, and 1 month postoperatively and at the last follow-up were 4.6 ± 3.2, 3.6 ± 3.3, 2.9 ± 3.2, and 1.4 ± 2.0, respectively, showing significant improvement (all, p < 0.001). The number of patients (percentage) with excellent or good satisfaction according to the MacNab criteria was 29 (70.7%). Major complications were not observed. Three patients underwent additional surgery after PLN because of persistent radiating pain.
Conclusions
PLN is a safe and feasible treatment option for ULDH. Treatment outcomes were favorable on average; however, the lack of consistency was a drawback.
Social-ecological factors influencing loneliness and social isolation in older people: A scoping review
Authors: Meehan Drew Eleanor , Grunseit Anne , Condie Jenna , HaGani Neta , Merom Dafna 
Published: August 2023

Abstract
There are growing calls from researchers and policy makers to redefine loneliness and social isolation (SI), as public health issues, and to move towards a transdisciplinary, systems-based approach, due to their association with significant health risks, particularly in older people. Research about loneliness and SI in older people has typically adopted a narrow focus, evaluating effects of individual and inter-personal factors on these experiences. Less is known about the community and societal influences that may be used to inform public health interventions. We conducted a scoping review applying Joanna Briggs Institute methodology and the social-ecological model framework in order to: i) identify the available evidence for the influence of the community and societal factors on loneliness and SI as experienced by older people; ii) examine how quantitative research about community- and societal-level factors of loneliness and SI in the older population is conducted; and iii) identify current knowledge gaps in relation to the use of the social-ecological model in this area. A total of 52 articles from 30 countries met the inclusion criteria, including 33 observational studies, primarily cross-sectional (88%), and 19 interventions, mostly (89%) pre-post evaluations. The majority of included articles measured loneliness only (n = 34, 65%), while 11 measured both loneliness and SI (21%). To measure these outcomes validated scales were frequently used. Eighteen community/societal factors were investigated in relation to loneliness and/or SI, most commonly, neighbourhood safety, access to public third-places and cultural practices. Three societal-level interventions were found: two campaigns to reduce ageism and one explored the impact of free public transport. Community-based interventions were either educational or enlisted volunteers to foster connections. There is a need for longitudinal studies to better understand the mechanism through which community- and societal- level factors affect loneliness and SI, which in turn guide interventions that utilise the social-ecological framework to these issues.
Improving the economic growth of smart cities based on wireless sensor networks
Authors: Yuan Chao , Zhao Ziqi 
Published: August 2023

Abstract
Although city economic growth is not linear in nature, it does typically display some instability. A particular level of financial volatility might be damaging to the growth of the urban economy. This paper focuses on the present state of the city's economy in order to address the financial losses brought on by the significant economic instability the city-wide. Throughout its growth phase, the global economic inspection, warning advancements in networks and data warehouses, and wireless sensor devices were examined, assessed, and stated the significance of Internet of Things (IoT) devices in the financial early warning mechanism investigated the growth procedure for financial tracking, contrasted a number of popular financial keep techniques, and suggested the utilization of IoT devices for urban financial surveillance, the concept of early warning, and the creation of an urban economic information system and a collection of IoT devices, the urban financial information surveillance, and early alerting system has conducted studies regarding the transfer of data, surveillance, projections, manufacturing, and presentation. Following the model simulation, the outcomes of the simulated research reveal that the system's financial instability forecast precision exceeds 81%, which has some practical relevance.
An Augmented Salp-swarm Optimization Based on Paillier Federated Multi-layer Perceptron (Pf-mlp) and Homomorphic Encryption Standard (Hes) Techniques for Data Security in Cloud Systems
Authors: S Kanakasabapathi R , Judith J.E. 
Published: August 2023

Abstract
Providing security to cloud data is one of the essential problems that have needed to be addressed in recent times due to the advancement and development of security breaches in technologies. As a result, the majority of existing research efforts aim to develop various types of cryptographic techniques for ensuring the data security of cloud systems. However, it faced challenges with complex computational operations, inefficient security models, high time consumption, and error outputs. Therefore, the proposed work aims to develop an advanced and hybrid optimization-based cryptographic methodology for increasing the security of cloud data. An Improved Salp-Swarm Optimization (ISSO) technique is deployed to obtain the random number required for secret key generation. In this work, two different encryption techniques, such as the Homomorphic Encryption Standard (HES) and the Paillier Federated Multi-Layer Perceptron (PF-MLP) model, are used for strengthening the security of the original health tweet dataset. Here, the efficacy and security level of these two encryption methodologies are validated for the purpose of identifying the most suitable mechanism to secure the health tweet dataset. For these approaches, the key pair is optimally generated by using an ISSO technique. This type of key generation can complicate matters for users who attempt to attack the original information. Moreover, the novel contribution of this work is that it incorporates the functions of advanced optimization and cryptographic mechanisms for securing the health tweet dataset against attacking users. For validating the performance of this system, various evaluation metrics have been used, and the validated results are compared with the proposed system to demonstrate the improvement of the proposed system.
Aetiology of community-acquired pneumonia among infants and children at a hospital in Vietnam: screening for multiple pathogens using molecular methods
Authors: Tran Xuan Duong , Hoang Van-Thuan , Goumballa Ndiaw , Vu Thi Nguyet , Tran Trong Kiem , Pham Thi Dung , Dao Thi-Loi , Vu Thi Thuy , Nguyen Duy Cuong , Nguyen Quoc Tien , Marty Pierre , Gautret Philippe 
Published: August 2023

Abstract
Objective: To investigate potential respiratory pathogens in children with community-acquired pneumonia (CAP) and risk factors for severe disease in a Vietnamese hospital.
Methods: Clinical data and laboratory results were collected. Twenty-four respiratory pathogens were tested from nasopharyngeal swabs using real-time PCR.
Results: 467 children with CAP were included, mean age = 15.4±13.3 months, 63.0% were male. Over 97% of patients had a positive PCR result. Majority of patients (87%) were positive for multiple (up to eight) pathogens. Rhinovirus (46%), respiratory syncytial virus (RSV) (24%), enterovirus (17%), and parainfluenza viruses-3 (13%) were the most frequent viruses. H. influenzae (61%), S. pneumoniae (45%) and M. catarrhalis (30%) were the most common bacteria. 128 (27 %) cases were classified as severe pneumonia. Presence of smokers at home, CRP level ≥ 50 mg/dL, RSV and H. influenzae PCR detection associated with a higher risk of severe pneumonia (aOR=2.11, P value=0.004; aOR=6.11, P value<0.0001; aOR=1.78, P value=0.03 and aOR=1.66, P value=0.04, respectively).
Conclusion: Causative agents of pneumonia in children are complex. Case-controlled and metagenomic studies need to be performed to further investigate the role of the presence of microbial agents in the respiratory tract on pneumonia in children to differentiate between colonisation and infection.
Unraveling the Relationship Between Cultural Food Habits and Chronic Obstructive Pulmonary Disease in Men: A Case-Control Study in Kazakhstan
Authors: Turdaliyeva Botagoz , Kulzhanov Maksut , Akhmetov Valikhan , Auyezova Ardak , Yussupova Nargiza , Karibayeva Indira 
Published: August 2023

Abstract
Background: Limited research has been conducted on the association between cultural food habits (CFH) and the risk of chronic obstructive pulmonary disease (COPD), and no studies have specifically investigated the long-term dietary impact on COPD risk in the Republic of Kazakhstan [1]. However, the prevalence of various non-communicable diseases, including COPD, is high in the country, and some of these diseases may be influenced by CFH. To better understand the relationship between CFH and non-communicable diseases, the Ministry of Healthcare of the Republic of Kazakhstan has provided funding for research through grant number OR12165486, titled "National Programme for the Introduction of Personalized and Preventive Medicine in The Republic of Kazakhstan (2021–2023)" (Grant number OR12165486). The current case-control study is being conducted as part of this grant.
Aim: We sought to investigate the association between long-term red meat consumption and risk of COPD.
Methods: The case – control study primarily targeted the population of the Almaty Observational Cohort, comprising 609 men aged 30 to 85 years. These participants were monitored for analysis purposes between 2018 and 2023, with an average age of 51.2 years (95% CI 48.1–54.3). The assessment of unprocessed and processed red meat consumption was conducted using a self-administered questionnaire in both 2018 and 2023.
Results: Among individuals with COPD, the predominant factors associated with the disease were the consumption of red meat more than 10 times per month (84.9%), a body mass index (BMI) over 25 (73.6%), the consumption of more than 100 grams of red meat per serving (62.3%), and the consumption of less than 100 grams of fresh fruits per serving (52.8%). In the control group, the primary factors were alcohol consumption in the past 12 months (69.2%), the consumption of red meat more than 10 times per month (62.9%), the consumption of more than 100 grams of red meat per serving (55.8%), and the consumption of fresh fruits less than 30 times per month (52.0%).
Conclusion: The findings suggest that high consumption of red meat, low consumption of fresh fruits and vegetables, and a preference for fatty foods may increase the risk of developing COPD among men in Kazakhstan. These results emphasize the importance of promoting balanced and healthy dietary habits to reduce the burden of COPD and improve public health.
A Risk Predictive Model for the Severity of Illness in Patients with Severe Fever with Thrombocytopenia Syndrome
Authors: Tao Shuai , Wu Yiran , Zhang Aiping , Liang Manman , Wang Zijian , Yang Jianghua 
Published: August 2023

Abstract
Background
Severe fever with thrombocytopenia syndrome (SFTS) is a newly identified infectious disease characterized by a high mortality rate and wide prevalence. The objective of our study was to investigate the factors that influence the severity of SFTS and develop a predictive model applicable to primary care settings.
Methods
This retrospective study examined a cohort of 169 patients with SFTS who received medical attention from May 2015 to February 2022. Clinical and laboratory data were compared between the mild and severe groups. Independent risk factors contributing to the severity of the patients' condition were assessed using multifactorial logistic regression analysis. Subsequently, a nomogram was constructed based on the outcomes of the regression analysis. The predictive model's discrimination and calibration were evaluated using metrics such as the concordance index (C-index), ROC curve, and Hosmer-Lemeshow analysis.
Results
A total of 169 patients diagnosed with SFTS were included in this study. A comprehensive analysis of 19 factors was conducted, including AGE, neurological manifestations, PLT, NEUT%, MONO%, CK, CK-MB, LDH, ALT, AST, BUN, Cr, Ca, APTT, PCT, HCT, ALB, HCT-ALB, and HGB. Logistic regression analysis revealed that PLT (OR = 0.930, 95% CI = 0.892–0.970), CK (OR = 1.005, 95% CI = 1.001–1.008), APTT (OR = 1.042, 95% CI = 1.002–1.083), LDH (OR = 1.004, 95% CI = 1.000-1.007), and NEUT% (OR = 1.062, 95% CI = 1.020–1.106) were identified as independent risk factors for disease severity. The constructed nomogram exhibited excellent predictive performance in estimating severe disease (C-index = 0.927, AUC = 0.927, sensitivity = 84.4%, specificity = 87.3%, Hosmer-Lemeshow analysis SD = 0.00051, and quantile of absolute error = 0.036).
Conclusions
Decreased PLT, increased LDH, CK, APTT, and NEUT% serve as reliable predictors of severe disease progression in patients with SFTS. Utilizing these five predictors, a predictive line chart exhibits strong capability in accurately assessing the risk of severe disease during the course of the illness.
Biomaterial composed of chitosan, riboflavin and hydroxyapatite for bone tissue regeneration
Authors: Gaweł Justyna , Milan Justyna , Zebrowski Jacek , Płoch Dariusz , Stefaniuk Ireneusz , Kus-Liśkiewicz Małgorzata 
Published: August 2023

Abstract
Bone tissue engineering is an ongoing field of research due to the existing of burning needs in restoration and reconstruction of damaged bone. Numerous studies have shown the development of the biomaterials based on the hydroxyapatite, major component of bones. Biomaterials engineering approaches involve using a combination of miscellaneous bioactive molecules which may promote cell proliferation, and thus, forming a scaffold with the environment which favor the regeneration process. Chitosan, naturally occurring biodegradable polymer, possess some essential features, i.e biodegradability, biocompatibility, and in solid phase good porosity, which may be contributed to promote cell adhesion. Moreover, doping the materials with other biocompounds, will create a unique and multifunctional scaffold useful in regenerative medicine. Riboflavin is an essential water-soluble vitamin, which participates in numerous biological process, such as transport, cell development and reproduction. Therefore, this study is focused on the manufacturing of the composite materials based on the hydroxyapatite, chitosan and riboflavin. Scanning electron microscopy showed the porosity of the composite biomaterial, important factor which can affect cell ingrowth and new bone formation. The infrared spectroscopy demonstrated chemical interlinking between hydroxyapatite and chitosan phases as well as no evidence for chemical interaction between RF and the CS-HAP scaffold. This may alter physical and chemical properties of the scaffold towards better performance in potential regenerative applications, particularly, when the matrix is supplemented with RF. Indeed, in vitro experiments showed that the riboflavin increased the cell proliferation and migration of the fibroblasts and osteosarcoma cells. Due to the urgent need of development of material with a potential to prevent of implant-associated infections, the antimicrobial and antioxidant activity of the composite were determined. The composite material showed the inhibitory effect on Staphylococcus aureus and exhibited higher antioxidant activity compare to pure chitosan. The antibacterial effect may be due to the generation of ROS level. Moreover, the riboflavin photochemical treatment with blue LED light enhanced the ROS level, which could be a more accessible and safe practice to treat the implant-associated infections. All things considered, incorporating riboflavin into the biocomposite scaffolds may accelerate new bone regeneration.
BAP31 promotes breast cancer progression by interaction with SERCA2
Authors: Liu Xiangtian , Xu Qiao , Qian Wenchang , Guan Haiyang , Jiang Dongbo , Yu Fazhi , Guo Qianying , Wu Mingming , Zhang Xiao , Zhang Weijie , Li Gaopeng , Yang Zhenye , Wu Zhengsheng , Pandey Vijay , Han Xinghua , Ma Xiaopeng , Lobie Peter E. , Yang Kun , Zhu Tao 
Published: August 2023

Abstract
Background
B-Cell receptor-associated protein 31 (BAP31) is a resident chaperone protein in the endoplasmic reticulum. It was observed herein that a higher expression of BAP31 mRNA was associated with a worse prognosis in breast cancer patients.
Methods
Breast cancer cells and normal breast tissue cells were used to confirm how BAP31 influences the progress of breast cancer both in vivo and vitro. Western blots and qRT-PCR assays supported the changes.
Results
Depletion of BAP31 in breast cancer cells increased apoptosis and decreased the capacities of proliferation, colony formation and invasion. BAP31 was observed to be associated with SERCA2, a sarco/endoplasmic reticulum Ca2+-ATPase. Depletion of BAP31 decreased endoplasmic reticulum Ca2+ storage with resultant ER stress and breast cancer cell death; which required BAP31 association with SERCA2 .
Conclusion
Hence, these findings have demonstrated that BAP31 enhanced the viability, oncogenicity and motility of breast cancer cells by modulation of endoplasmic reticulum Ca2+ homeostasis. Thus, BAP31 promotes progression of breast cancer.