bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Reconfigurable 3-DOF Parallel Kinematics Machine
Authors: Rosyid Abdur , Stefanini Cesare , El-Khasawneh Bashar 
Published: January 2023

AbstractThis paper proposes a novel, reconfigurable parallel kinematics machine with three degrees of freedom that can be used for various three-axis manipulation tasks, including machining. By locking some joints, the proposed parallel kinematics machine (PKM) can be transformed into four topologies with eight configurations to attain certain kinematic properties while keeping the number of its degrees of freedom unchanged. Either the proximal or intermediate prismatic joints of the reconfigurable PKM can be actuated. Some of the configurations are orthogonal configurations having a large rectangular cuboid workspace, and some other configurations are non-orthogonal configurations which provide the capability to perform a machining task to a large workpiece in various positions with respect to the machine. Accordingly, the proposed machine can be transformed from an orthogonal machine to a non-orthogonal machine with the advantages of each. The mobility of the various topologies of the reconfigurable PKM is rigorously analyzed using the screw theory. The workspace is analyzed using a graphical approach and verified by a computational approach. The pose kinematics shows that the various topologies have unified kinematics. The differential kinematics shows that the singularities in the various configurations occur at the workspace boundary. Similarly, the stiffness analysis shows that the low-stiffness postures occur around the workspace boundary. Accordingly, a used workspace far from the workspace boundary easily avoids the singularities and the low stiffness.
Effect of Ischemic Preconditioning on Acute Recovery in Elite Judo Athletes: A Randomized, Single-Blind, Crossover Trial
Authors: Ceylan Bayram , Taşkın Hasan Basri , Šimenko Jožef 
Published: January 2023

Purpose: The ischemic preconditioning (IPC) method has been shown to aid the recovery processes; however, no studies have been done to assess its acute recovery use in judo. This study aimed to examine IPC of lower limbs effects on recovery after a judo-specific performance in highly trained male judokas and its applicability during a competition day. Methods: A single-blind, placebo-randomized crossover study was carried out on a sample of 13 elite male judo athletes. They undertook measurements of body composition, judo-specific task (Special Judo Fitness Test), jump performance, handgrip strength, lactate, blood pressure, perceived exertion, and delayed-onset muscle soreness. IPC was applied on the legs and inflated 50 mm Hg above the systolic blood pressure for 5 minutes and repeated 3 times for each leg, with 5 minutes of reperfusion. Two-way analysis of variance with repeated measurements was used to determine changes between interventions and measurement times. Paired-sample t test and 1-way repeated-measures analysis of variance was used to determine the difference among measurement times. Statistical significance was set at P < .05. Results: The IPC intervention resulted in (1) decreased heart rate at 30 and 60 minutes during recovery (P = .002; P = .001), (2) better countermovement jump performance at 60 minutes (P = .05), (3) lower perceived-muscle-soreness scores (P = .006), and (4) maintained handgrip strength compared with placebo. Conclusions: The present study revealed that IPC applied to judo athletes following judo-specific exercise resulted in better cardiovascular and neuromuscular recovery and could be a useful tool to enhance recovery during judo competition breaks between preliminaries and final block.
Incidence and multimodal imaging characteristics of macular neovascularisation subtypes in Chinese neovascular age-related macular degeneration patients
Authors: Zhang Yining , Gan Yuhong , Zeng Yunkao , Zhuang Xuenan , Zhang Xiongze , Ji Yuying , Su Yongyue , Wen Feng 
Published: January 2023

AimsTo investigate the incidence of macular neovascularisation (MNV) subtypes of neovascular age-related macular degeneration (nAMD) and summarise these subtypes’ clinical features in the Chinese population using multimodal imaging.MethodsWe retrospectively analysed 506 consecutive treatment-naïve nAMD patients (582 eyes). Incidence of MNV subtypes and clinical features were recorded based on their multimodal images. The classification of MNV subtypes in nAMD patients were referred to Consensus on Neovascular Age-related Macular Degeneration Nonmenclature (CONAN) study group classifications.Results460 eyes of 389 nAMD patients were included in our study. 68.5% (315/460) of nAMD eyes were from male. According to CONAN, we identified type 1 macular neovascularisation (MNV) in 61.1% of eyes (281/460), type 2 MNV in 16.3% of eyes (75/460), type 3 MNV in 2.0% of eyes (9/460), mixed type 1 and type 2 MNV in 20.6% of eyes (95/460). 58% of eyes (267/460) were diagnosed as polypoidal choroidal vasculopathy lesions (PCV). 45.2% of eyes (208/460) with PCV lesions were type 1 MNV and 12.8% of eyes (59/460) with PCV lesions were co-occurred with type 2 MNV.ConclusionBased on the consensus anatomical classification system developed by the CONAN Study Group, we updated the incidence of MNV subtypes and found that PCV was the most common subtype and type 3 MNV was the least common subtype among Chinese nAMD patients. In addition, the co-occurrence of PCV and type 2 MNV was typically observed, and its frequency was reported in our study.
Akkermansia muciniphilacounteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
Authors: Daniel Noëmie , Gewirtz Andrew T , Chassaing Benoit 
Published: January 2023

BackgroundAccumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria,Akkermansia muciniphila.ObjectiveInvestigate, in mice, the potential of administration of exogenousA. muciniphilaas a means to protect against detrimental impacts of emulsifiers.ResultsDaily oral administration ofA. muciniphilaprevented phenotypic consequences of consumption of both CMC and P80, including hyperphagia, weight gain and dysglycaemia.A. muciniphilaadministration also counteracted the low-grade intestinal inflammation-induced CMC and P80. Furthermore,A. muciniphilasupplementation prevented the proximal impacts of CMC and P80 on gut microbiota that are thought to drive low-grade chronic inflammation and metabolic dysregulations. Specifically,A. muciniphilaprevented alterations in species composition and encroachment of gut microbiota that were otherwise induced by CMC and P80. Remarkably, we finally report that CMC and P80 altered the colonic transcriptome, whileA. muciniphilalargely protected against these alterations.ConclusionDaily administration ofA. muciniphilaprotects against the detrimental impact of emulsifiers on both the microbiota and host. These results support the notion that use ofA. muciniphilaas a probiotic can help maintain intestinal and metabolic health amidst the broad array of modern stresses that can promote chronic inflammatory diseases.
Distinct disease mechanisms may underlie cognitive decline related to hearing loss in different age groups
Authors: van 't Hooft Jochum J , Pelkmans Wiesje , Tomassen Jori , Smits Cas , Legdeur Nienke , den Braber Anouk , Barkhof Frederik , van Berckel Bart , Yaqub Maqsood , Scheltens Philip , Pijnenburg Yolande AL , Visser Pieter Jelle , Tijms Betty M 
Published: January 2023

BackgroundHearing loss in older adults is associated with increased dementia risk. Underlying mechanisms that connect hearing loss with dementia remain largely unclear.MethodsWe studied the association of hearing loss and biomarkers for dementia risk in two age groups with normal cognition: 65 participants from the European Medical Information Framework (EMIF)-Alzheimer’s disease (AD) 90+ study (oldest-old; mean age 92.7 years, 56.9% female) and 60 participants from the EMIF-AD PreclinAD study (younger-old; mean age 74.4, 43.3% female). Hearing function was tested by the ‘digits-in-noise test’ and cognition by repeated neuropsychological evaluation. Regressions and generalised estimating equations were used to test the association of hearing function and PET-derived amyloid burden, and linear mixed models were used to test the association of hearing function and cognitive decline. In the oldest-old group, mediation analyses were performed to study whether cognitive decline is mediated through regional brain atrophy.ResultsIn oldest-old individuals, hearing function was not associated with amyloid pathology (p=0.7), whereas in the younger-old individuals hearing loss was associated with higher amyloid burden (p=0.0034). In oldest-old individuals, poorer hearing was associated with a steeper decline in memory, global cognition and language, and in the younger-old with steeper decline in language only. The hippocampus and nucleus accumbens mediated the effects of hearing loss on memory and global cognition in the oldest-old individuals.ConclusionsHearing loss was associated with amyloid binding in younger-old individuals only, and with cognitive decline in both age groups. These results suggest that mechanisms linking hearing loss with risk for dementia depends on age.
Late time cosmology in $$f(R,{{\mathcal {G}}})$$ gravity with exponential interactions
Authors: Chanda A. , Halder A. , Majumdar A. S. , Paul B. C. 
Published: January 2023

AbstractCosmological models with f(R) modified gravity are significant to investigate the present and late-time behavior of the Universe. The dynamics of the Universe is studied in the framework of $$f(R)= R + \gamma R^2- \lambda \left( \frac{R}{3m_s^2} \right) ^{\delta }$$

f

(
R
)

=
R
+
γ

R
2

-
λ

R

3

m
s
2

δ

gravity ($$\gamma $$
γ
, $$\lambda $$
λ
, $$\delta $$
δ
are arbitrary constants) with a coupled Gauss–Bonnet (GB) term in the gravitational action and estimate the constraints on the model parameters as well as the late time behavior of the Universe. In this case, the coupled Gauss–Bonnet term is coupled with a free scalar field in the presence of interacting fluid. In addition, we investigate the same for a different form of gravity $$f(R)=R$$

f
(
R
)
=
R

, where the coupled GB term is coupled with a scalar field in a self-interacting potential.
Learning loss experience and control motive by Zillennial generation in Indonesia
Authors: Parahita Bagas Narendra , Astutik Dwi , Ghufronudin Ghufronudin , Yuhastina Yuhastina 
Published: January 2023

<span lang="EN-US">The development of the COVID-19 situation in Indonesia affected particularly education sector in Indonesia significantly when learning loss occurs. The majority of students forced to attend online learning during the pandemic era are Generation Z (Gen Z). Gen Z is viewed as a digital natives group that can adapt quickly to online learning, but independent online learning situations make Gen Z vulnerable to experiencing learning loss. It will be interesting to find out the process of controlling learning loss done by Gen Z as digital natives. This research used a qualitative method with a phenomenological approach. The main informant consisted of 32 students selected purposively with the criteria of those born in 2000-2008. Few in-depth interviews were conducted offline and the majority of them are conducted online. The finding of research shows particularly that the experience of Zillennial generation group (cohort) with online learning before the pandemic (Because-motives) and during the pandemic can equip them to control learning loss they feel conscious (In-order-to-motive). </span><span lang="EN-US">Another finding leads to the creation of three Gen Z <em>Typication</em>s in online learning during the pandemic time including inconsistent, proactive, learning independence, and desperation <em>Typication</em>. Generation Z group exists as one generation consciously experiencing loss of learning during pandemic incidence. </span>
Circulating Progenitor Cells Are Associated With Bioprosthetic Aortic Valve Deterioration: A Preliminary Study
Authors: Kanaji Yoshihisa , Ozcan Ilke , Toya Takumi , Gulati Rajiv , Young Melissa , Kakuta Tsunekazu , Lerman Lilach O. , Lerman Amir 
Published: January 2023

Background
Mechanisms underlying bioprosthetic valve deterioration are multifactorial and incompletely elucidated. Reparative circulating progenitor cells, and conversely calcification‐associated osteocalcin expressing circulating progenitor cells, have been linked to native aortic valve deterioration. However, their role in bioprosthetic valve deterioration remains elusive. This study sought to evaluate the contribution of different subpopulations of circulating progenitor cells in bioprosthetic valve deterioration.

Methods and Results

This single‐center prospective study enrolled 121 patients who had peripheral blood mononuclear cells isolated before bioprosthetic aortic valve replacement and had an echocardiographic follow‐up ≥2 years after the procedure. Using flow cytometry, fresh peripheral blood mononuclear cells were analyzed for the surface markers CD34, CD133, and osteocalcin. Bioprosthetic valve deterioration was evaluated by hemodynamic valve deterioration (HVD) using echocardiography, which was defined as an elevated mean transprosthetic gradient ≥30 mm Hg or at least moderate intraprosthetic regurgitation. Sixteen patients (13.2%) developed HVD during follow‐up for a median of 5.9 years. Patients with HVD showed significantly lower levels of reparative CD34
+
CD133
+
cells and higher levels of osteocalcin‐positive cells than those without HVD (CD34
+
CD133
+
cells: 125 [80, 210] versus 270 [130, 420],
P
=0.002; osteocalcin‐positive cells: 3060 [523, 5528] versus 670 [180, 1930],
P
=0.005 respectively). Decreased level of CD34
+
CD133
+
cells was a significant predictor of HVD (hazard ratio, 0.995 [95% CI, 0.990%–0.999%]).

Conclusions

Circulating levels of CD34
+
CD133
+
cells and osteocalcin‐positive cells were significantly associated with the subsequent occurrence of HVD in patients undergoing bioprosthetic aortic valve replacement. Circulating progenitor cells might play a vital role in the mechanism, risk stratification, and a potential therapeutic target for patients with bioprosthetic valve deterioration.
Lovewear: Haptic Clothing that Allows Intimate Exploration for Movement-Impaired People
Authors: Corti Emanuela , Parati Ivan , Dils Christian 
Published: January 2023

AbstractPeople with disabilities often face physical, political, and societal barriers in expressing their sexuality. The lack of inclusivity in the sex toy market does not support an autonomous experience for impaired individuals who cannot operate toys without external assistance. Lovewear is a collaborative art-science project that combines user-centered design principles with soft robotics integrated into textiles. The aim is to offer an autonomous experience through haptic feedback, allowing self-exploration of intimate sensations and sexual pleasure to females with motor impairments. A pillow interface activates an underwear garment: While caressing and touching the pillow, the wearer triggers the underwear’s inflatable i actuators. This transdisciplinary project used a mixed-methods research design; the objective is to promote the embedment of technology into everyday garments, to improve the wearer’s quality of life.
Inland Flooding and Rainfall from Hurricane Irene and Tropical Storm Lee (2011): Coupled Atmosphere–Wave–Ocean Model Simulations and Remote Sensing and In Situ Observations with a Machine Learning Tool
Authors: Kerns Brandon W. , Chen Shuyi S. 
Published: January 2023

Abstract
Inland flooding from landfalling tropical cyclones (TCs) is a major cause of death and damage to property and infrastructure worldwide. The mid-Atlantic region of the United States was devastated by Hurricane Irene and Tropical Storm Lee during late August–early September 2011, when the two storms produced sequential heavy rainfall and record flooding. Many rivers and streams reached their all-time record discharge to date. This study aims at 1) better understanding and predicting TC rainfall using various observed rainfall products and a high-resolution coupled atmosphere–wave–ocean model, namely, the Unified Wave Interface-Coupled Model (UWIN-CM), 2) characterizing inland flooding using streamflow data, and 3) improving prediction of TC-induced inland flooding using UWIN-CM and a machine learning K-nearest-neighbor (KNN) model. The results show that there is a wide range of uncertainty in satellite and radar–gauge-observed rainfall products in terms of rain-rate distribution and cumulative rainfall over the mid-Atlantic region. UWIN-CM rainfall is closer to the radar–gauge data than satellite data over land. Streamflow in most large rivers (>500 cfs) peaked after Lee, which reflects the sequential rainfall contributions of the two storms. The rainfall–streamflow–discharge response times were dependent on the size of the stream and the peak rain rates. To better predict rainfall and flooding, UWIN-CM and observed rainfall are used with the machine learning KNN regression model for prediction of severity of TC-induced inland flooding hazard. These results demonstrate the value of a stepped approach for rainfall and flood prediction toward a fully coupled atmosphere–ocean–land/hydrology model in the future.
Complication Rates in Osteotome and Drill Techniques in External Auditory Canal Exostoses: A Systematic Review and Meta-Analysis
Authors: Swisher Austin R. , Singh Priyanka , Debbaneh Peter , Rivero Alexander 
Published: January 2023

Objectives: To assess and compare complication rates of symptomatic external auditory canal (EAC) exostoses treated with drill versus osteotome canalplasty. Databases Reviewed: PubMed/Medline, OVID, EMBASE, Web of Science, Google Scholar. Methods: A systematic review and meta-analysis in accordance with PRISMA guidelines and standardized bias assessment using the JBI critical appraisal checklist was performed. Studies containing original outcome data on drill and osteotome canalplasty were included. The primary study outcome was complication rates. Results: Fifteen studies were included, encompassing 1399 total patients (1788 ears) with 530 and 1258 ears in the osteotome and drill groups, respectively. Ten studies used a drill, 2 used an osteotome, and 3 used both. The most frequently reported complications were tympanic membrane (TM) perforation (osteotome group: 5.3% [95% CI: 1.7%-10.9%]; drill group: 3.8% [1.5%-7.1%]), sensorineural hearing loss (SNHL) (0.69% [0.07%-1.9%]; 4.3% [2.2%-7.0%]), and postoperative stenosis (1.1% [0.0005%-4.3%]; 4.1% [1.9%-7.0%]). Use of the osteotome was associated with a lower rate of SNHL ( P < .05) and stenosis ( P < .05), and a higher rate of TM perforation ( P < .05). Heterogeneity of the studies included in the analyzed complications ranged from moderate to high. Level of evidence in the included studies ranged from 2b to 4 and all studies had an overall low risk of bias. Conclusion: While an osteotome technique may increase the risk of TM perforation, drill canaloplasty may increase the risk of SNHL and postoperative stenosis in EAC exostectomy. The exact quantity of hearing loss could not be definitively evaluated. Additional research with participant randomization is needed to assess clinical efficacy. Level of Evidence: Level 8
Antiproliferative and apoptotic effects of conditioned medium released from human amniotic epithelial stem cells on breast and cervical cancer cells
Authors: Jafari Ameneh , Niknejad Hassan , Rezaei-Tavirani Mostafa , Sarrami-Forooshani Ramin , Gilanchi Samira , Jafari Zahra 
Published: January 2023

Introduction Human amniotic membrane (hAM) and its cells have been proposed for several clinical applications, including cancer therapy. However, reports on the anticancer effects of human amniotic epithelial stem cells-conditioned media (hAECs-CM) are limited. This work aims to evaluate the anticancer effects of hAECs-CM on cervical cancer and breast cancer cell lines in vitro . Methods Human term placentas were gained from uncomplicated Cesarean sections from healthy donor women. After amnion peeling from the chorion, its epithelial stem cells were isolated and cultured, and its conditioned medium (CM) was collected for experiments. MTT assay was performed to assess cancer cells viability. Migration rate of cancer cells was examined via wound healing assay. Cell-cycle distribution and apoptosis were determined using flow cytometry. Results Based on MTT assay hAECs-CM was cytotoxic against cancerous cell lines in a dose-time-dependent manner. After 48 h of treatment with hAECs-CM pure, the cell viability of breast cancer cells includes MCF-7 and MDA-MB-231 reached to 73.2% and 65.5%, respectively. In the same situation, HeLa cervical cancer cell line revealed the lowest viability by 47.3%. The wound-healing assay displayed an incomplete wound closure of scratched MDA-MB-231 cells and significant inhibition of cell migration after hAECs-CM treatment. The results also revealed that hAECs-CM exerted anti-proliferation activity by prompting cell cycle arrest and apoptosis of cancer cells. Conclusions: hAECs-CM is a potent candidate for inducing apoptosis and simultaneously inhibition of the proliferation and migration of cancer cells via inhibiting cell cycle blockade.