bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of early cardiac dysfunction and heterogeneity after pressure and volume overload in mice by high-frequency echocardiographic strain imaging
Authors: Xu Ran , Ding Zhiwen , Li Hao , Shi Jing , Cheng Leilei , Xu Huixiong , Wu Jian , Zou Yunzeng 
Published: January 2023

ObjectAortic stenosis and regurgitation are clinically important conditions characterized with different hypertrophic types induced by pressure or volume overload, respectively, but with comparable cardiac function in compensated stage. Speckle-tracking based strain imaging has been applied to assess subtle alterations in cardiac abnormality, but its application in differentiating these two types of ventricular hypertrophy is still sparse. Here, we performed strain imaging analysis of cardiac remodeling in these two loading conditions.MethodsC57BL/6J mice were subjected to transverse aortic constriction (TAC)-induced pressure overload or aortic regurgitation (AR)-induced volume overload. Conventional echocardiography and strain imaging were comprehensively assessed to detect stimulus-specific alterations in TAC and AR hearts.ResultsConventional echocardiography did not detect significant changes in left ventricular systolic (ejection fraction and fractional shortening) and diastolic (E/E’) function in either TAC or AR mice. On the contrary, global strain analysis revealed global longitudinal strain and strain rate were remarkably impaired in TAC while preserved in AR mice, although global radial, and circumferential strain and strain rate were significantly reduced in both models. Regional strain analysis in the long axis demonstrated that longitudinal strain and strain rate in all or most segments were decreased in TAC but maintained or slightly dented in AR mice, while radial strain and strain rate indicated overt decline in both models. Moreover, decreased radial and circumferential strain and strain rate were observed in most segments of TAC and AR mice in the short axis.ConclusionStrain imaging is superior to conventional echocardiography to detect subtle changes in myocardial deformation, with longitudinal strain and strain rate indicating distinct functional changes in pressure versus volume overload myocardial hypertrophy, making it potentially an advanced approach for early detection and differential diagnosis of cardiac dysfunction.
Relationship between serum sodium levels and all-cause mortality in congestive heart failure patients: A retrospective cohort study based on the Mimic-III database
Authors: Peng Shixuan , Peng Jianxing , Yang Lianju , Ke Weiqi 
Published: January 2023

BackgroundThe relationship between serum sodium levels and mortality in congestive heart failure (CHF) patients has not been well-studied previously. The non-linear correlation between serum sodium levels and mortality in patients with heart failure is currently controversial, and the relationship between different serum sodium levels and mortality is disputed. The goal of this study is to look into the relationship between serum sodium levels and all-cause mortality in people with CHF after controlling for other factors.MethodsThe publicly accessible Mimic III database was the source of data for our study. We use the ICU Admission Scoring System to collect demographic data, laboratory findings, comorbidities, vital signs, and scoring information for each patient. Cox proportional risk analysis, smooth curve fitting, and the Kaplan-Meier survival curve were used to assess the relationship between baseline sodium levels and all-cause mortality in CHF patients.ResultsThe segmentation regression model discovered a turning point value of serum sodium levels (137.5 mmol/L) between serum sodium levels and all-cause mortality. According to the results of the fully adjusted Cox proportional hazard model, lower serum sodium levels (&lt;137.5 mmol/L) were associated with an increased risk of 30, 90, 365-day, and 4-year all-cause deaths. The HRs and 95th confidence intervals were 0.96 (0.94, 0.99), 0.96 (0.94, 0.99), 0.96 (0.94, 0.98), and 0.96 (0.95, 0.98), respectively; the higher serum sodium levels (≥137.5 mmol/L) were related to an associated multiplied risk of 30, 90, 365-day, and 4-year all-cause deaths; the HRs and 95th confidence intervals were 1.02 (1.00, 1.05), 1.02 (1.00, 1.04), 1.02 (1.00, 1.03), and 1.02 (1.00, 1.03), respectively.ConclusionSerum sodium levels were u-shaped about all-cause mortality. In individuals with CHF, serum sodium levels are linked to an elevated risk of short-, medium-, and long-term all-cause mortality.
Research review and prospects of the 2000 giant Yigong long-runout landslide: Volume, formation mechanism and recurrence period, Tibetan plateau, China
Authors: Guo Changbao , Yuan Hao , Wu Ruian , Yan Yiqiu , Yang Zhihua 
Published: January 2023

The long-runout landslide is an unusual landslide with great drop height, long sliding distance, large volume, and high velocity, which is characterized by strong kinetic energy, fragmentation and entrainment effect. The landslide and its induced hazard chain may produce serious consequences. Based on remote sensing interpretation, field investigation and simulation, this paper summarizes the research progress of the 2000 giant Yigong long-runout landslide in Tibet, analyzes the initiating mechanism, volume and sliding velocity of the Yigong landslide, and further reveals that endogenic and exogenic geological processes are the main influencing factor of the Yigong landslide. It is also found that the landslide has a periodic initiating mechanism with characteristics of head-cut and recurrence. However, there are great differences in the existing studies on the volume of the slide source zone in the Yigong landslide. This paper calculates the landslide volume based on ArcGIS spatial analysis and obtains an initial landslide volume of approximately 9.225 × 107 m3. The landslide final deposition volume is approximately 2.81∼3.06 × 108 m3, which is consistent with the other researchers. Moreover, there are two potential dangerous rock mass in the slide source zone, with a total volume of approximately 1.86 × 108 m3. Dangerous rock mass may form the hazard chain of landslide-river blockage-dam break again and lead to significant disasters. Hence, we suggest the following research on Yigong landslide: Stability of the potential dangerous rock mass in the slide source zone, the prediction of the hazard chain, monitoring and early warning for the landslide. It is of great significance to guide the construction of major projects such as railway and hydropower projects and hazard prevention and mitigation in this area.
Landslide mechanism and stability of an open-pit slope: The Manglai open-pit coal mine
Authors: Chen Tao , Shu Jisen , Han Liu , Tovele Gerson. S. V. , Li Baosheng 
Published: January 2023

A clear understanding of landslide mechanisms and stability analyses is of great significance for landslide monitoring, prediction, and control. A large-scale end wall landslide occurred and its area reached 47,752 m2 on August 7–20, 2020, in the Manglai open-pit coal mine, China. In this paper, the engineering geological survey, mechanical test, large-deformation finite element numerical method, limit equilibrium method and analytical formula are used to analyze how the groundwater level rise caused this end wall failure and landslide. The engineering geological conditions, hydrogeological conditions, landslide activity signs and physical and mechanical parameter calibration of the sliding mass are investigated in detail and tested. Three-dimensional and two-dimensional numerical models of slopes are established, and an analytical formula calculation method to calculate the factor of safety (FoS) is proposed when sliding cracks are located on the top and toe of a slope. The results indicate that the fault fracture zone, soft strata, continuous heavy rainfall, and groundwater were the main contributors to this landslide. The three-dimensional numerical calculation results are consistent with the deformation and failure process of the slope observed in the field, which shows a retrogressive progressive failure mode. The calculation results of SLOPE/W and the analytical formula are consistent; i.e., when the groundwater level rises to +950, the stability of the end wall reaches the critical stability state. With the passage of time, the creep of the sliding surface accelerates until the entire end wall landslide.
Application of GMDH model to predict pore pressure
Authors: Gao Guozhong , Hazbeh Omid , Rajabi Meysam , Tabasi Somayeh , Ghorbani Hamzeh , Seyedkamali Reza , Shayanmanesh Milad , Radwan Ahmed E. , Mosavi Amir H. 
Published: January 2023

Pore pressure (PP) is one of the essential and very critical parameters in the oil and gas industry, especially in reservoir engineering, exploitation, and production. Forecasting this valuable parameter can prevent huge costs incurred by the oil and gas industry. This research aims to develop a algorithm to better predict PP in subsurface -formations. Based on this, information from three wells (F1, F2, and F3) representing one of the Middle East oil fields was used in this research. The input variables used in this research include; laterolog (LLS), photoelectric index (PEF), compressional wave velocity (Vp), porosity (NPHI), gamma ray (spectral) (SGR), density (RHOB), gamma ray (corrected) (CGR), shear wave velocity (Vs), caliper (CALI), resistivity (ILD), and sonic transit time (DT). Based on the results presented in the heat map (Spearman’s correlation), it can be concluded that the pairs of parameters RHOB-PEF, CGR-SGR, RHOB-CALL, DT-PEF, PP-RHOB, Vs-RHOB, ILD-LLS, DT-CGR, and DT-NPHI are connected. In this research the GS-GMDH methods is used for modeling which is based on the Group method of data handling (GMDH). The results of this research show that this algorithm has an average error of RMSE = 1.88 Psi and R2 = 0.9997, indicating its high-performance accuracy. The difference between this method and the conventional GMDH method is that it can use three or more variables instead of two, which can improve prediction accuracy. Furthermore, by using the input of each neuron layer, the proposed model can communicate with other adjacent and non-adjacent layers to solve complex problems in the simplest possible way.
Controlling influence of water and ice on eruptive style and edifice construction in the Mount Melbourne Volcanic Field (northern Victoria Land, Antarctica)
Authors: Smellie J. L. , Rocchi S. , Di Vincenzo G. 
Published: January 2023

The Mount Melbourne Volcanic Field (MMVF) is part of the West Antarctic Rift System, one of Earth’s largest intra-continental rift zones. It contains numerous small, compositionally diverse (alkali basalt–benmoreite) flank and satellite vents of Late Miocene–Pliocene age (≤12.50 Ma; mainly less than 2.5 Ma). They demonstrate a wide range of morphologies and eruptive mechanisms despite overlapping compositions and elevations, and they occur in a relatively small area surrounding the active Mount Melbourne stratovolcano. The volcanic outcrops fall into several main categories based on eruptive style: scoria cones, tuff cones, megapillow complexes, and shield volcanoes. Using the analysis of lithofacies and appraisal of the internal architectures of the outcrops, we have interpreted the likely eruptive setting for each center and examined the links between the environmental conditions and the resulting volcanic edifice types. Previous investigations assumed a glacial setting for most of the centers but without giving supporting evidence. We demonstrate that the local contemporary environmental conditions exerted a dominant control on the resulting volcanic edifices (i.e., the presence or absence of water, including ice or snow). The scoria cones erupted under dry subaerial conditions. Products of highly explosive hydrovolcanic eruptions are represented by tuff cones. The water involved was mainly glacial (meltwater) but may have been marine in a few examples, based on a comparison of the contrasting internal architectures of tuff cones erupted in confined (glacial) and unconfined (marine, lacustrine) settings. One of the glaciovolcanic tuff cones ceased activity shortly after it began transitioning to a tuya. The megapillow complexes are highly distinctive and have not been previously recognized in glaciovolcanic successions. They are subglacial effusive sequences emplaced as interconnected megapillows, lobes, and thick simple sheet lavas. They are believed to have erupted at moderately high discharge and reduced cooling rates in partially drained englacial vaults under ice, probably several hundred meters in thickness. Finally, several overlapping small shield volcanoes crop out mainly in the Cape Washington peninsula area. They are constructed of previously unrecognized multiple ‘a‘ā lava-fed deltas, erupted in association with a thin draping ice cover c. 50–145 m thick. Our study highlights how effectively water in all its forms (e.g., snow, ice, and any meltwater) or its absence exerts a fundamental control on eruption dynamics and volcano construction. When linked to published ages and40Ar/39Ar dates produced by this study, the new environmental information indicates that the Late Pliocene–Pleistocene landscape was mainly an icefield rather than a persistent topography-drowning ice sheet. Ice thicknesses also generally increased toward the present.
Contribution of deep-earth fluids to the geothermal system: A case study in the Arxan volcanic region, northeastern China
Authors: Cui Yueju , Sun Fengxia , Liu Lei , Xie Chao , Li Jing , Chen Zhi , Li Ying , Du Jianguo 
Published: January 2023

Investigations of the hot spring water and gas in the volcanic region are involved in assessing geothermal resources and understanding groundwater circulation, volcano, and earthquake activities. The origins of water and gas of the hot springs, lakes, rivers, and rain in the Arxan volcanic region (AVR), northeastern (NE) China, were investigated by conducting a field survey and geochemical analysis. The low electrical conductivity (40–835 μS/cm) and low total dissolved solids (TDS, 23.83–540.00 mg/L) of the water samples indicate that they are fresh water. δ18O and δD values of the water samples range from −4.1% to −16.0% and from −61.3% to −119.9%, respectively. Enrichment of heavy isotopes in the rainwater and the crater lake waters was caused by evaporation. The component H2O of the water samples predominantly originated from the meteoric water, with less than 1 vol% contributed by deep-earth fluids. Ions in the rain sample were predominantly derived from sea salt and continental aerosol. Ions in the surface water samples had multiple origins (mineral dissolution, atmospheric, and anthropogenic sources). While the ions in the hot spring water were predominantly derived from both the dissolution of rocks and deep-earth fluids, the latter contributed 73%–87% of Cl− and 86%–99% of Na+ to the hot spring waters. Gases from the hot springs were composed of more than 95% N2 and less than 5% O2 and Ar, with 3He/4He ratios of 0.14–1.17 RA (RA=1.4×10−6). Excess N2, Ar, He, and CO2 of the hot springs were mainly derived from both the crust and upper mantle. About 3%–23% of the total He in the bubbling gases from the crater lake waters and hot springs is derived from the mantle, implying a supplement of heat energy from the mantle to the geothermal systems. Significantly, about 12% of the He dissolved in the Budonghe water is derived from the mantle, indicating that plenty of mantle-derived heat transported by deep-earth fluids keeps the river water from freezing. Our results indicate that Cl and Na ions and 3He/4He ratio are the feasible geochemical indicators for source partitioning of geothermal fluids.
Abdominal obesity and dsyglycemia are risk factors for liver fibrosis progression in NAFLD subjects: A population-based study
Authors: Julián María Teresa , Ballesta Sílvia , Pera Guillem , Pérez-Montes de Oca Alejandra , Soldevila Berta , Caballería Llorenç , Morillas Rosa , Expósito Carmen , Martínez–Escudé Alba , Puig-Domingo Manel , Franch-Nadal Josep , Torán Pere , Cusi Kenneth , Julve Josep , Mauricio Dídac , Alonso Núria 
Published: January 2023

ObjectiveTo investigate longitudinal changes in the liver stiffness measurement (LSM) in the general adult population without known liver disease and to describe its association with metabolic risk factors, with a special focus on subjects with non-alcoholic fatty liver disease (NAFLD) and dysglycemia.Material and MethodsA longitudinal adult population-based cohort study was conducted in Catalonia. LSM was measured by transient elastography (TE) at baseline and follow-up (median: 4.2 years). Subgroup with NAFLD and dysglycemia were analyzed. Moderate-to-advanced liver fibrosis was defined as LSM ≥8.0 kPa and LSM ≥9.2 kPa respectively.ResultsAmong 1.478 subjects evaluated, the cumulative incidence of LSM ≥8.0 kPa and ≥9.2 kPa at follow-up was 2.8% and 1.9%, respectively. This incidence was higher in NAFLD (7.1% for LSM ≥8.0 kPa and 5% for LSM ≥9.2 kPa) and dysglycemia (6.2% for LSM ≥8.0 kPa and 4.7% for LSM ≥9.2 kPa) subgroups. In the global cohort, the multivariate analyses showed that dysglycemia, abdominal obesity and atherogenic dyslipidemia were significantly associated with progression to moderate-to-advanced liver fibrosis. Female sex was negatively associated. In subjects with NAFLD, abdominal obesity and dysglycemia were associated with changes in LSM to ≥8.0 kPa and ≥9.2 kPa at follow-up. A decline in LSM value to &lt;8 kPa was observed in 64% of those subjects with a baseline LSM ≥8.0 kPa.ConclusionsIn this population study, the presence of abdominal obesity and dysglycemia were the main risk metabolic factors associated with moderate-to-advanced liver fibrosis development over time in general populations as well as in subjects with NAFLD.
Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma(LGG)
Authors: Liu He , Wang Jiao , Luo Tao , Zhen Zhiming , Liu Li , Zheng Yalan , Zhang Chaobin , Hu Xiaofei 
Published: January 2023

IntroductionGlioma is the most common primary tumor in the brain.Integrin beta 2(ITGB2) is a member of the leukocyte integrin family (leukocyte integrin), participating in lymphocyte recycling and homing, cell adhesion, and cell surface-mediated signal transduction. However, few studies on ITGB2 in gliomas have been reported yet.This study first discussed the relationship between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma.MethodsWe collected Clinical data and transcription of glioma patients from TCGA, CGGA, and Rembrant datasets to analyze the differential expression of ITGB2 mRNA in glioma tissues and normal tissues. The box polts to evaluated the expression patterns of ITGB2 in different molecular subtypes. Receiver operating characteristic curve (ROC) were used to evaluate and verify the reliability of the model. Kaplan-Meier survival curves to evaluated the relationship between the level of ITGB2 mRNA expression and overall survival (OS). Using cox regression analysis to verify the ability of ITGB2 as an independent predictor of OS in glioma patients. We use TIMER to analyze and visualize the association between immune infiltration levels and a range of variables. The methylation of GBMLGG patients were obtained from the TCGA database through the biological portal.ResultsITGB2 can be a potential marker for mesenchymal molecular subtype gliomas. COX regression analysis shows that ITGB2 is an independent predictive marker of OS in malignant glioma patients. Biological processes show that ITGB2 has involved glioma immune-related activities, especially closely related to B cells, CD4+Tcells, macrophages, neutrophils, and dendritic cells. ITGB2 is negatively regulated by ITGB2 methylation, resulting in low expression in LGG tissues. Low expression of ITGB2 and high methylation indicate good OS in patients with LGG. The ITGB2 methylation risk score (ITMRS) obtained from the ITGB2 methylation CpG site can better predict the OS of LGG patients. We used univariate and multivariate cox regression analysis of methylationsites, used the R language predict function to obtain the risk score of these ITGB2 methylation sites(ITMRS).DiscussionITGB2 can be used as a potential marker of mesenchymal molecular subtypes of gliomas and as an independent predictive marker of OS in patients with malignant gliomas. The ITMRS we established can be used as an independent prognostic factor for LGG and provide a new idea for the diagnosis and treatment of LGG.
Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life
Authors: Sousa-Vidal Érica Kássia , Henrique Guilherme , Silva Renata Elen Costa da , Serrano-Nascimento Caroline 
Published: January 2023

IntroductionDEHP is an endocrine disruptor widely used in the production of malleable plastics. DEHP exposure was associated with altered hypothalamic-pituitary-thyroid (HPT) axis function. Although previous studies reported deleterious effects of DEHP exposure during the intrauterine period, few studies have evaluated the direct effects triggered by this endocrine disruptor on the offspring animals' thyroid function. This study aimed to investigate the impact of intrauterine exposure to DEHP on the HPT axis function programming of the offspring animals during adulthood.MethodsPregnant Wistar rats were orally treated with corn oil or corn oil supplemented with DEHP (0.48 or 4.8 mg/kg/day) throughout the gestational period. The offspring rats were euthanized on the 90th postnatal day. Hypothalamus, pituitary, thyroid, and liver were collected to analyze gene expression and protein content through qPCR and Western Blot. Blood was collected to determine TSH and thyroid hormone levels through fluorometric or chemiluminescence immunoassays.ResultsIn the adult F1 female rats, the highest dose of DEHP decreased TSH serum levels. In the thyroid, DEHP reduced the gene expression and/or protein content of NIS, TSHR, TG, TPO, MCT8, NKX2.1, PAX8, and FOXE1. These data are consistent with the reduction in T4 serum levels of the F1 DEHP-exposed female rats. In the liver, DEHP exposure increased the mRNA expression of Dio1 and Ttr, while the highest dose of DEHP reduced the mRNA expression of Ugt1a1 and Ugt1a6. Conversely, in the F1 male adult rats, TSHB expression and TSH serum levels were increased in DEHP-exposed animals. In the thyroid, except for the reduced protein content of TSHR, none of the evaluated genes/proteins were altered by DEHP. TH serum levels were not changed in the DEHP-exposed F1 male rats compared to the control group. Additionally, there were no significant alterations in the expression of hepatic enzymes in these animals.Discussion/ConclusionsOur results demonstrated, for the first time, that intrauterine exposure to DEHP disrupts the HPT axis function in male and female offspring rats and strongly suggest that DEHP exposure increases the susceptibility of the offspring animals to develop thyroid dysfunctions during adulthood.