bluuebunny/crossref_metadata_2025_split huggingface dataset:
Von Industrie 4.0 zu Industrie 5.0 – Idee, Konzept und Wahrnehmung
Authors: Vogel-Heuser Birgit , Bengler Klaus 
Published: August 2023

ZusammenfassungIn der sich rasant entwickelnden Landschaft der industriellen Automatisierung läutet das Aufkommen von Industrie 5.0 (I5.0) einen Paradigmenwechsel hin zu einem stärker kollaborativen und menschzentrierten Ansatz ein. In diesem Beitrag wird die Rolle der Mensch-Maschine-Kollaboration und menschzentrierter Werkzeuge bei der Förderung einer symbiotischen Beziehung zwischen fortschrittlichen Technologien und menschlichen Benutzern untersucht, um so das volle Potenzial von I5.0 zu erschließen. Als nächste Stufe in der Entwicklung des Produktionssektors zielt I5.0 darauf ab, ein Gleichgewicht zwischen Automatisierung und menschlichen Fähigkeiten herzustellen und die sich ergänzenden Stärken beider zu nutzen. Es werden Technologien vorgestellt, welche menschzentrierte Lösungen zur Steigerung von Produktivität, Flexibilität und Nachhaltigkeit in der Fabrik der Zukunft fokussieren.
Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis
Authors: Chhonker Yashpal S. , Bjerum Catherine , Bala Veenu , Ouattara Allassane F. , Koudou Benjamin G. , Gabo Toki P. , Alshehri Abdullah , Meïté Abdoulaye , Fischer Peter U. , Weil Gary J. , King Christopher L. , Budge Philip J. , Murry Daryl J. 
Published: August 2023

Moxidectin (MOX) is a milbemycin endectocide recently approved by the U.S. FDA for the treatment of onchocerciasis in persons at least 12 years of age. MOX has been shown to have a good safety profile in recent clinical trials. The efficacy of MOX for the treatment of lymphatic filariasis (LF) and its potential use in mass drug administration protocols for the elimination of LF is currently under evaluation. In the context of a clinical trial, we investigated the pharmacokinetics and drug interactions of a combination of MOX plus albendazole (ALB) with or without diethylcarbamazine (DEC) compared to ivermectin (IVM) plus ALB with or without DEC in the following four different treatment arms: (I) IVM (0.2mg/kg) plus DEC (6 mg/kg) and ALB (400mg); (II) IVM plus ALB; (III) MOX (8 mg) plus DEC and ALB; and (IV) MOX plus ALB. Drug concentrations were determined using validated liquid chromatography-mass spectrometric methods. Pharmacokinetic parameters were determined using standard non-compartmental analysis methods. Statistical analysis was performed using JMP software. Fifty-eight of 164 study participants (53 men and five women) were included with ages ranging from 18 to 63 yrs (mean = 37). MOX apparent oral clearance (Cl/F) ranged from 0.7 to 10.8 L/hr with Cmax values ranging from 20.8 to 314.5 ng/mL. The mean (range) area under the curve (AUC)0-∞ for MOX, 3405 ng*hr/mL (742–11376), and IVM 1906 ng*hr/mL (692–5900), varied over a ~15.3 and ~8.5-fold range, respectively. The geometric mean ratio for Cmax, AUC0–t, and AUC0–∞ were within the no-drug interaction range of 80–125% for all drugs. This indicates that the addition of MOX to ALB alone or ALB plus DEC for LF therapy did not alter the drug exposure of co-administered drugs compared to IVM combinations.
Clinical Trial Registration: NCT04410406, https://clinicaltrials.gov/.
Admission NLPR predicts long-term mortality in patients with acute ischemic stroke: A retrospective analysis of the MIMIC-III database
Authors: Su Xiao , Zhao Shigang , Zhang Nan 
Published: August 2023

BackgroundThe neutrophil to lymphocyte*platelet ratio (NLPR) is a new index based on platelets, neutrophils, and lymphocytes associated with the prognosis of patients with infectious diseases and cancer. However, its use in acute ischemic stroke has rarely been reported. This study examined the relationship between levels of systemic immunoinflammatory indices at admission and patient outcomes at different times after onset to assess stroke prognosis by NLPR.MethodsThis was a retrospective cohort study. The data from 1222 stroke patients were obtained from multi-parameter intelligent monitoring in the Intensive Care III database(MIMIC- III). Cox proportional risk model was conducted to evaluate the relation between NLPR, all-cause mortality, and ischemic. The results were further verified via a subgroup analysis.ResultsAfter adjusting for multiple covariates, it was found that NLPR was related with all-cause mortality in stroke patients. High NLPR was accompanied by an increase in mortality with longer follow-up (30 days: HR = 1.52, 95% CI = 1.14–2.02,90 days: HR = 1.67, 95% CI = 1.29–2.16, 365 days: HR = 1.56, 95% CI = 1.24–1.96 and 2 years: HR = 1.52, 95% CI = 1.22–1.89).ConclusionThe neutrophil to lymphocyte*platelet ratio (NLPR) are related to long-term adverse outcomes in patients with acute ischemic stroke. Therefore, NLPR is a promising inflammatory index for predicting the long-term prognosis of stroke.
Putting ICU triage guidelines into practice: A simulation study using observations and interviews
Authors: Abma Inger L. , Olthuis Gert J. , Maassen Irma T. H. M. , Knippenberg Marjan L. , Moviat Miriam , Hasker Annie J. , Buenen A. G. , Fikkers Bernard G. , Oerlemans Anke J. M. 
Published: August 2023

Background
The COVID-19 pandemic has prompted many countries to formulate guidelines on how to deal with a worst-case scenario in which the number of patients needing intensive care unit (ICU) care exceeds the number of available beds. This study aims to explore the experiences of triage teams when triaging fictitious patients with the Dutch triage guidelines. It provides an overview of the factors that influence decision-making when performing ICU triage with triage guidelines.

Methods
Eight triage teams from four hospitals were given files of fictitious patients needing intensive care and instructed to triage these patients. Sessions were observed and audio-recorded. Four focus group interviews with triage team members were held to reflect on the sessions and the Dutch guidelines. The results were analyzed by inductive content analysis.

Results
The Dutch triage guidelines were the main basis for making triage decisions. However, some teams also allowed their own considerations (outside of the guidelines) to play a role when making triage decisions, for example to help avoid using non-medical criteria such as prioritization based on age group. Group processes also played a role in decision-making: triage choices can be influenced by the triagists’ opinion on the guidelines and the carefulness with which they are applied. Intensivists, being most experienced in prognostication of critical illness, often had the most decisive role during triage sessions.

Conclusions
Using the Dutch triage guidelines is feasible, but there were some inconsistencies in prioritization between teams that may be undesirable. ICU triage guideline writers should consider which aspects of their criteria might, when applied in practice, lead to inconsistencies or ethically questionable prioritization of patients. Practical training of triage team members in applying the guidelines, including explanation of the rationale underlying the triage criteria, might improve the willingness and ability of triage teams to follow the guidelines closely.
Predicting the risk of hypertension using machine learning algorithms: A cross sectional study in Ethiopia
Authors: Islam Md. Merajul , Alam Md. Jahangir , Maniruzzaman Md , Ahmed N. A. M. Faisal , Ali Md Sujan , Rahman Md. Jahanur , Roy Dulal Chandra 
Published: August 2023

Background and objectivesHypertension (HTN), a major global health concern, is a leading cause of cardiovascular disease, premature death and disability, worldwide. It is important to develop an automated system to diagnose HTN at an early stage. Therefore, this study devised a machine learning (ML) system for predicting patients with the risk of developing HTN in Ethiopia.Materials and methodsThe HTN data was taken from Ethiopia, which included 612 respondents with 27 factors. We employed Boruta-based feature selection method to identify the important risk factors of HTN. The four well-known models [logistics regression, artificial neural network, random forest, and extreme gradient boosting (XGB)] were developed to predict HTN patients on the training set using the selected risk factors. The performances of the models were evaluated by accuracy, precision, recall, F1-score, and area under the curve (AUC) on the testing set. Additionally, the SHapley Additive exPlanations (SHAP) method is one of the explainable artificial intelligences (XAI) methods, was used to investigate the associated predictive risk factors of HTN.ResultsThe overall prevalence of HTN patients is 21.2%. This study showed that XGB-based model was the most appropriate model for predicting patients with the risk of HTN and achieved the accuracy of 88.81%, precision of 89.62%, recall of 97.04%, F1-score of 93.18%, and AUC of 0. 894. The XBG with SHAP analysis reveal that age, weight, fat, income, body mass index, diabetes mulitas, salt, history of HTN, drinking, and smoking were the associated risk factors of developing HTN.ConclusionsThe proposed framework provides an effective tool for accurately predicting individuals in Ethiopia who are at risk for developing HTN at an early stage and may help with early prevention and individualized treatment.
Suffering from chronic tinnitus, chronic neck pain, or both: Does it impact the presence of signs and symptoms of central sensitization?
Authors: De Meulemeester Kayleigh , Meeus Mira , De Pauw Robby , Cagnie Barbara , Keppler Hannah , Lenoir Dorine 
Published: August 2023

Chronic subjective tinnitus is a prevalent symptom, which has many similarities with chronic pain. Central sensitization is considered as a possible underlying mechanism of both symptoms. Central sensitization has already been investigated in chronic pain populations but not in patients with chronic subjective tinnitus. Therefore, the main objective of this cross-sectional study was to compare signs and symptoms, indicative for central sensitization, in tinnitus patients with and without chronic idiopathic neck pain, patients with chronic idiopathic neck pain only, and healthy controls. Also, differences in psychological and lifestyle factors, possibly influencing the association between central sensitization and tinnitus, were examined as well as correlations between signs and symptoms of central sensitization, and tinnitus, pain, psychological and lifestyle factors. Differences in signs and symptoms of central sensitization were examined using the self-report Central Sensitization Inventory and QST protocol (local and distant mechanical and heat hyperalgesia, conditioned pain modulation). Tinnitus, pain, psychological and lifestyle factors were evaluated using self-report questionnaires. Symptoms of central sensitization and local mechanical hyperalgesia were significantly more present in both tinnitus groups, compared to healthy controls, but were most extensive in the group with chronic tinnitus+chronic idiopathic neck pain. Distant mechanical hyperalgesia, indicative for central sensitization, was only observed in the group with both chronic tinnitus+chronic idiopathic neck pain. This group also displayed a significantly higher psychological burden and poorer sleep than patients with chronic tinnitus only and healthy controls. Signs and symptoms of central sensitization were also shown to be associated with tinnitus impact, pain-related disability, psychological burden and sleep disturbances. This study shows preliminary evidence for the presence of central sensitization in patients with chronic tinnitus+chronic idiopathic neck pain. This could be explained by the higher perceived tinnitus impact, psychological burden and sleep problems in this group.Trial registration:This study is registered asNCT05186259(www.clinicaltrials.gov).
Approaches and geographical locations of respectful maternity care research: A scoping review
Authors: Shuman Hannah L. , Grupp Annika M. , Robb Lauren A. , Akers Katherine G. , Bedi Gurbani , Shah Miloni A. , Janis Andrea , Caldart Caroline G. , Gupta Urvashi , Vaghasia Janki K. , Panneerselvam Aishwarya , Kazeem Aisha O. , Amutah-Onukagha Ndidiamaka N. , Levine Diane L. 
Published: August 2023

BackgroundPeripartum mistreatment of women contributes to maternal mortality across the globe and disproportionately affects vulnerable populations. While traditionally recognized in low/low-middle-income countries, the extent of research on respectful maternity care and the types of mistreatment occurring in high-income countries is not well understood. We conducted a scoping review to 1) map existing respectful maternity care research by location, country income level, and approach, 2) determine if high-income countries have been studied equally when compared to low/low-middle-income countries, and 3) analyze the types of disrespectful care found in high-income countries.MethodsA systematic search for published literature up to April 2021 using PubMed/MEDLINE, EMBASE, CINAHL Complete, and the Maternity & Infant Care Database was performed. Studies were included if they were full-length journal articles, published in any language, reporting original data on disrespectful maternal care received from healthcare providers during childbirth. Study location, country income level, types of mistreatment reported, and treatment interventions were extracted. This study was registered on PROSPERO, number CRD42021255337.ResultsA total of 346 included studies were categorized by research approach, including direct labor observation, surveys, interviews, and focus groups. Interviews and surveys were the most common research approaches utilized (47% and 29% of all articles, respectively). Only 61 (17.6%) of these studies were conducted in high-income countries. The most common forms of mistreatment reported in high-income countries were lack of informed consent, emotional mistreatment, and stigma/discrimination.ConclusionsMapping existing research on respectful maternity care by location and country income level reveals limited research in high-income countries and identifies a need for a more global approach. Furthermore, studies of respectful maternity care in high-income countries identify the occurrence of all forms of mistreatment, clashing with biases that suggest respectful maternity care is only an issue in low-income countries and calling for additional research to identify interventions that embrace an equitable, patient-centric empowerment model of maternity care.
Is scientific evidence enough? Using expert opinion to fill gaps in data in antimicrobial resistance research
Authors: Cousins Melanie , Parmley E. Jane , Greer Amy L. , Neiterman Elena , Lambraki Irene A. , Graells Tiscar , Léger Anaïs , Henriksson Patrik J. G. , Troell Max , Wernli Didier , Søgaard Jørgensen Peter , Carson Carolee A. , Majowicz Shannon E. 
Published: August 2023

Background
Antimicrobial Resistance (AMR) is a global problem with large health and economic consequences. Current gaps in quantitative data are a major limitation for creating models intended to simulate the drivers of AMR. As an intermediate step, expert knowledge and opinion could be utilized to fill gaps in knowledge for areas of the system where quantitative data does not yet exist or are hard to quantify. Therefore, the objective of this study was to identify quantifiable data about the current state of the factors that drive AMR and the strengths and directions of relationships between the factors from statements made by a group of experts from the One Health system that drives AMR development and transmission in a European context.

Methods
This study builds upon previous work that developed a causal loop diagram of AMR using input from two workshops conducted in 2019 in Sweden with experts within the European food system context. A secondary analysis of the workshop transcripts was conducted to identify semi-quantitative data to parameterize drivers in a model of AMR.

Main findings
Participants spoke about AMR by combining their personal experiences with professional expertise within their fields. The analysis of participants’ statements provided semi-quantitative data that can help inform a future of AMR emergence and transmission based on a causal loop diagram of AMR in a Swedish One Health system context.

Conclusion
Using transcripts of a workshop including participants with diverse expertise across the system that drives AMR, we gained invaluable insight into the past, current, and potential future states of the major drivers of AMR, particularly where quantitative data are lacking.
Bridging External Stakeholders and Sustainability Literature
Authors: Santos Manoela Pastor dos , Raposo Marcela Melo Rego , Ferreira Edivan Alexandre , Berssaneti Fernando Tobal , Salerno Mario Sergio , Carvalho Marly Monteiro de 
Published: August 2023

Goal: This study aims at bridging the stakeholder and sustainability literature, focusing on the project context. It aims at identifying the main challenges of mapping and dealing with the external stakeholders concerning the sustainability perspective during the project development.
Design/Methodology/Approach: The research design is a literature review merging bibliometric and content analysis. The sampling process includes two primary databases, Web of Science and Scopus. We applied the data on the software VoSViewer for the first phase of bibliometric analysis and on software NVivo for better content analysis.
Results: This article contributed to the literature with an in-depth analysis of 96 articles that bridge stakeholder and sustainability. It identifies the stakeholder influence on sustainability issues in projects and the main environmental challenges faced. Besides, there is a prominence of the environmental dimension of the triple bottom line; therefore, the social aspect is little considered in stakeholder management projects.
Limitations of the investigation: This study presents limitations related to the research methods selected. First, the sampling strategy constrains the sample related to the search strings and logical operators applied. The application of the research's exclusion criteria brings subjectivity to the analysis.
Practical implications: The research highlights the significance of the identification and mapping of the critical stakeholders for alignment of the sustainability strategy for the project development, which helps to explore risks associated with the sustainability aspects.
Originality/Value: We contribute by exploring the gap in research in the intersection between stakeholders and sustainability literature in project management.
A modal definition of ideal alveolar oxygen
Authors: Peyton Philip J. 
Published: August 2023

AbstractIn the three‐compartment model of lung ventilation‐perfusion heterogeneity (VA/Q scatter), both Bohr dead space and shunt equations require values for central “ideal” compartment O2 and CO2 partial pressures. However, the ideal alveolar gas equation most accurately calculates mixed (ideal and alveolar dead space) PAO2. A novel “modal” definition has been validated for ideal alveolar CO2 partial pressure, at the VA/Q ratio in a lung distribution where CO2 elimination is maximal. A multicompartment computer model of physiological, lognormal distributions of VA and Q was used to identify modal “ideal” PAO2, and find a modification of the alveolar gas equation to estimate it across a wide range of severity of VA/Q heterogeneity and FIO2. This was then validated in vivo using data from a study of 36 anesthetized, ventilated patients with FIO2 0.35–80. Substitution in the alveolar gas equation of respiratory exchange ratio R with achieved excellent agreement (r2 = 0.999) between the calculated ideal PAO2 and the alveolar‐capillary Pc'O2 at the modal VO2 point (“modal” Pc'O2), across a range of log standard deviation of VA 0.25–1.75, true shunt 0%–20%, overall VA/Q 0.4–1.6, and FIO2 0.18–1.0, where the modeled PaO2 was over 50 mm Hg. Modal ideal PAO2 can be reliably estimated using routine blood gas measurements.
Regularity results for a class of widely degenerate parabolic equations
Authors: Ambrosio Pasquale , Passarelli di Napoli Antonia 
Published: August 2023

Abstract
Motivated by applications to gas filtration problems, we
study the regularity of weak solutions to the strongly degenerate
parabolic PDE

u
t

-

div
⁡

(

(

|

D
⁢
u

|

-
ν

)

+

p
-
1

⁢

D
⁢
u

|

D
⁢
u

|

)

=
f

in
⁢

Ω
T

=

Ω
×

(
0
,
T
)

,

u_{t}-\operatorname{div}\Bigl{(}(\lvert Du\rvert-\nu)_{+}^{p-1}\frac{Du}{%
\lvert Du\rvert}\Bigr{)}=f\quad\text{in }\Omega_{T}=\Omega\times(0,T),

where Ω is a bounded domain in

ℝ
n

{\mathbb{R}^{n}}

for

n
≥
2

{n\geq 2}

,

p
≥
2

{p\geq 2}

, ν is a positive constant and

(
⋅
)

+

{(\,\cdot\,)_{+}}

stands for the positive part. Assuming that the datum f belongs
to a suitable Lebesgue–Sobolev parabolic space, we establish the Sobolev
spatial regularity of a nonlinear function of the spatial gradient
of the weak solutions, which in turn implies the existence of the
weak time derivative

u
t

{u_{t}}

. The main novelty here is that the structure
function of the above equation satisfies standard growth and ellipticity
conditions only outside a ball with radius ν centered at the
origin. We would like to point out that the first result obtained
here can be considered, on the one hand, as the parabolic counterpart
of an elliptic result established in [L. Brasco, G. Carlier and F. Santambrogio,
Congested traffic dynamics, weak flows and very degenerate elliptic equations [corrected version of mr2584740],
J. Math. Pures Appl. (9) 93 2010, 6, 652–671], and on the other
hand as the extension to a strongly degenerate context of some known
results for less degenerate parabolic equations.
Molecular characterization of the new clinical entity associated with congenital adrenal hyperplasia: the CAH-X syndrome in the Spanish population
Authors: Figueras Laura Martínez , Pacheco Rafael Muñoz , González Dolores García , Domènech María Arriba , Zubicaray Begoña Ezquieta 
Published: August 2023

Abstract

Objectives
The chimeras causing the CAH-X syndrome (SCAH-X) result from recombination between CYP21A2-TNXB and their respective pseudogenes (CYP21A1P-TNXA). The clinical manifestations of this syndrome include congenital adrenal hyperplasia (CAH) and Ehlers–Danlos syndrome (EDS). Since SCAH-X has been recently described, the number of publications available is limited. The objective of this study was to set up a molecular approach and a screening algorithm for detecting CAH-X chimeras, determine their frequency and distribution in the Spanish population, and assess their clinical pattern of occurrence in a group of patients.

Methods
A total of 186 patients were eligible for CAH-X molecular genetic testing. Testing included MLPA, heterodimer detection by capillary gel electrophoresis, and sequencing of exons 40, 41, and 43 of TNXB. A review was performed of the medical history of 20 patients from three hospitals of reference and the signs and symptoms of EDS they exhibited.

Results
In total, 78 CAH patients were carriers of CAH-X chimeras (41.9 %). Forty-six patients were carriers of CH1 (24.7 %), 24 of CH2 (12.9 %), and 8 of CH3 (4.3 %), with a heterogeneous geographical distribution. Seven (35 %) of the 20 carriers of a CAH-X chimera who underwent clinical examination experienced clinical manifestations of EDS.

Conclusions
The impact of SCAH-X in the Spanish population was assessed by genetic testing. In the light of the clinical pattern of occurrence and significant prevalence of SCAH-X in the Spanish population, early diagnosis of this entity is essential for an appropriate follow-up of clinical manifestations.