bluuebunny/crossref_metadata_2025_split huggingface dataset:
KAJIAN YURIDIS PERSETUJUAN TINDAKAN MEDIK (INFORMED CONSENT) DALAM PERSPEKTIF UNDANG-UNDANG NOMOR 29 TAHUN 2004 TENTANG PRAKTIK KEDOKTERAN
Authors: Aprilyansyah Mahdi Surya 
Published: September 2023

Tujuan penelitian ini adalah mendeskripsikan mendeskripsikan tanggung jawab dokter dalam melakukan tindakan medik dalam perspektif Undang-Undang Nomor 29 Tahun 2004 tentang Praktik Kedokteran. Metode yang digunakan adalah metode hukum normatif yang memberikan argumentasi hukum sebagai dasar penentu terhadap suatu peristiwa telah benar atau salah serta bagaimana sebaiknya peristiwa itu menurut hukum. Hasil penelitian ini mengemukakan bahwa tanggung jawab dokter dalam melakukan tindakan mendik harus memiliki persetujuan tindakan medik terlebih dahulu. Persetujuan tindakan medik (informed consent) antara dokter dan pasien atau keluarga harus berdasarkan Undang-Undang Nomor 29 Tahun 2004 tentang Praktik Kedokteran dengan tujuan memberikan kepastian bahwa pasien atau keluarga pasien dianggap telah mengetahui atau menyetujui apa yang terjadi berkaitan dengan tindakan medik yang dilakukan dokter. Hal ini juga untuk mengantisipasi terkait resiko maupun efek samping dari tindakan tersebut sehingga jika terdapat suatu kerugian yang diderita oleh pasien atau keluarga pasien akibat dari resiko atau efek samping dari tindakan medik yang dilakukan, dokter tidak dapat dimintai pertanggung jawaban sepanjang tindakan medik.
TINJAUAN YURIDIS TERHADAP EUTHANASIA DALAM SISTEM HUKUM PIDANA INDONESIA
Authors: Novita  
Published: September 2023

Istilah euthanasia berasal dari bahasa Yunani, yaitu eu yang berarti indah, bagus, terhormat atau dalam bahasa Inggris diartikan dengan grecefully and with dignit, dan thanatos yang berarti mati atau mayat. Secara harafiah berarti kematian yang terjadi dengan baik dan menyenangkan tanpa penderitaan. Sehingga euthanasia dikenal sebagai suatu tindakan untuk mengakhiri hidup seseorang karena tidak memiliki peluang untuk hidup, biasanya pada penderita penyakit yang memiliki peluang kecil untuk tetap hidup. Dalam kasus tertentu ada keadaan mengakhiri kehidupan yang sangat mirip dengan euthanasia, tetapi sebenarnya bukan euthanasia. Disebut sebagai pseudo-euthanasia atau dalam bahasa Indonesia adalah euthanasia semu dan secara hukum tidak dapat ditetapkan sebagai euthanasia. Indonesia belum memiliki kebijakan formulasi ataupun aturan yang mengatur khusus tentang euthanasia. Legalitas euthanasia dilihat berdasarkan Kitab Undang-undang Hukum Pidana (KUHP).[1] Euthanasia di Indonesia tidak diperbolehkan karena alasan menghilangkan nyawa seseorang, dalam Kitab Undang-undang Hukum Pidana Indonesia bahwa usaha apapun yang menyebabkan hilangnya nyawa seseorang, baik disengaja atau tidak disengaja masuk dalam kategori pembunuhan.
TINJAUAN YURIDIS TERHADAP PELANGGARAN PROTOKOL KESEHATAN DALAM MASA PANDEMIC COVID 19
Authors: Devrayno  , Putra Jurdan Lingga 
Published: September 2023

Corona Virus Disease 2019 (COVID-19) yang sekarang ini mewabah diseluruh dunia termasuk Indonesia tentunya membawa dampak yang sedemikian besar diberbagai sektor, seperti halnya pendidikan, pelayanan jasa angkutan, maupun yang paling berpengaruh adalah sektor ekonomi, banyaknya usaha yang tutup hal ini disebabkan adanya kebijakan yang membatasi kegiatan usaha tersebut serta daya beli masyarakat yang menurut akibat banyaknya terjadi pemutusan hubungan kerja atau adanya merumahkan pegawai/karyawan.
Bahkan untuk melakukan kegiatan usaha kadang kala dilakukan dengan melanggar kebijakan protokol kesehatan. upaya melakukan pencegahan terhadap terjadinya pelanggaran protokol kesehatan dapat berjalan secara efektif maka diperlukan pemahaman yang seksama terhadap faktor faktor yang dapat memicu timbulnya pelanggaran tersebut, pencegahannya dapat dilakukan secara preventif dan represif.
Dalam penegakan hukum terhadap pelaku pelanggaran protokol kesehatan supaya lebih maksimal, maka perlu dikaji dari beberapa unsur, seperti unsur substansi atau undang undang yang mengatur tindak pidanan tersebut, unsur aparat penegak hukumnya yang berkerja secara professional dan unsur budaya masyarakat terhadap adanya tindak pidana melaan petugas. Sehingga penegakan hukum lebih mendatangkan manafaat bagi masyarakat.
REGULASI DAN IMPLEMENTASI BIAYA ADMINISTRASI PADA PERBANKAN SYARIAH
Authors: Kurniawan Rahmad , Akbar Wahyu , Safitri Novi Angga , Theara Resha 
Published: September 2023

Artikel ini bertujuan untuk menganalis regulasi dan implmentasi biaya administrasi pada perbankan syariah. Masalah muncul karena biaya yang berkaitan dengan prosedur administrasi merupakan syarat untuk pelaksanaan pembiayaan. Dalam situasi ini, beberapa pihak yang diuntungkan dan beberapa pihak yang dirugikan. Artikel ini menggunakan Penulisan penelitian ini menggunakan metode normatif melalui literatur kajian pustaka (library research). Hasil penelitian menunjukkan bahwa biaya administrasi merupakan biaya yang timbul sehubungan dengan fungsi administrasi. Biaya administrasi termasuk yang terkait dengan penetapan kebijakan, perencanaan, administrasi, dan pengendalian di seluruh perusahaan. Agar biaya administrasi ini terhindar dari komponen riba yang dilarang oleh Islam, ada dua syarat yang perlu dipenuhi yaitu, Biaya administrasi harus berlandaskan pada perhitungan sebenarnya dari biaya yang digunakan untuk menyelesaikan suatu transaksi, termasuk biaya pemrosesan dokumen, biaya materai, gaji dan dana penyelidikan, serta dana untuk telekomunikasi. Dari segi regulasi, pemberlakuan biaya administrasi ke dalam akad pembiyaan di dalam bank syariah Indonesia telah memenuhi persyaratan dan memiliki kekuatan hukum. Di kemudian hari, pengenalan biaya administrasi ke dalam akad pembiayaan akan memiliki efek hukum pada pemangku kepentingan di sektor keuangan syariah Indonesia sebagai struktur hukum yang disepakati dan dilembagakan.
Job Satisfaction and Employee Performance in Indonesia
Authors: Angga Kurniawan  
Published: September 2023

This study aims to determine the extent to which motivation, and communication on job satisfaction and their impact on the performance of employees of construction service companies in Indonesia. The data used in this study are primary data collected from respondents' answers based on the questionnaire given, as many as 305 people. The analysis method uses the Path Analysis method with the help of SPSS version 22.0. Statistical testing uses the simultaneous significance test (F test), the individual parameter significance test (t test) and the Sobel test mediation test.
The results showed that simultaneously the variables of motivation, communication and job satisfaction had a direct influence on employee performance. Partially shows that the motivation variable and the communication variable have a positive correlation and have a direct and indirect effect on employee performance. While the implications of the variable job satisfaction as an intervening variable have a direct influence on employee performance. The results showed that job satisfaction had a direct positive and significant effect on employee performance. Based on the results of the analysis, the path coefficient (Beta) of the job satisfaction variable on the employee performance variable is 0.645 with a significance of 0.001.
Price Transmission in Vertical Markets: An Empirical Analysis of Red Gram
Authors: P. D. Shivagangavva , Gracy C. P. 
Published: September 2023

Price transmission provides insight into vertical and horizontal integration of agricultural markets this will help in producer and consumer welfare. We have examined price transmission process between wholesale and retail markets by adopting Error correction model (ECM). This study has taken case of Red gram (Cajanuscajan) wholesale and retail markets in Bengaluru and Mumbai respectively It has used wholesale and retail prices data from secondary sources. The results revealed that retail price does not react completely to changes in producer price within one month. Dal price responds differently to seed price in its increasing and decreasing phases. Decreasing phase of seed price is associated with one lag, implying dal price to adjust slowly to seed price, say in a month’s time period. The estimated results were 0.98 in Bengaluru and 0.97 in Mumbai in the rising phase (ECT+) and 0.58 and 0.64 respectively in these markets in the falling phase (ECT-), suggesting that the positive deviations of price from long-run equilibrium are reduced faster in a month’s time period than the negative deviations in Bengaluru. Both values are significant but ECT+ induces a greater change in the tur dal than ECT- in Bengaluru. Where as in Mumbai values of ECT+ and ECT- are also showing faster changes almost. This clearly explains the asymmetry in red gram seed to dal price transmission in Bengaluru and Mumbai.
Comparative Analysis of MEM, RPMI 1640 Media on Rabies Virus Propagation in Vero Cells and Virus Quantification by FAT
Authors: Sekar Thangaraj , Grace Blessy Emy , N. Karthick , Nivetha K.  , Parveen M. Hajistha , Mohan Ganesan Chandra 
Published: September 2023

Rabies disease can be preventable through vaccination is the only way for effective control and the vaccine is administered as post exposure prophylaxis method (PEP) along with rabies immunoglobulin. For the preparation of the vaccine, the high titre rabies virus has to be propagated in suitable host system like Vero cells. In this study, the virus was propagated in tissue culture flask in two different tissue culture media namely MEM and RPMI-1640, keeping Vero cell line as the host system. This preliminary study is to find the media that yields a better viral titre as high, the influence of harvesting intervals on viral titre for the reason that the vaccine yield is directly proportional to the viral titre during the virus propagation stage and leads to cost effective vaccine. The Vero cell was revived from passage 154 and the part of cells were subjected for adaptation in RPMI-1640 media with gradual media replacement. The passaging of RPMI 1640 media cells were continued until it reaches the equal cell count of MEM (p-158). The confluent monolayer of Vero cells was maintained in the same passage level with appropriate media. The cell count of MEM media, RPMI-1640 were 10.28 x 106 and 10.35 x 106 respectively in 25cm2 tissue culture flasks. The Vero cells were sub-cultured in 175 cm2 tissue culture flasks infected with 0.2 MOI (Multiplicity of Infection) of virus and the viral titration was estimated through FAT test (Fluorescent Antibody Test). The highest viral titre obtained from RPMI-1640 media batch (10-6.125/ml) and MEM media batch (10-6.25 /ml). The two days interval viral harvests shows (Batch 1 & 3) the viral titre log ranged between 10-4.375 to 10-5.875 and three days interval harvests (Batch 2 & 4) the viral titre log ranged between 10-3.750 to 10-6.250 per mL.
Effect of Crop Establishment Methods and Fertility Management on Growth, Yield and Economics of Rice (Oryza sativa L.)
Authors: Baboo Kaptan , Nand Vishuddha , Kumar Rajesh , Singh A. K. , Kumar Neeraj , Kushwaha Bharat Lal , Maurya Shivanad , Prakash Ram 
Published: September 2023

The experiment was carried out at Agronomy Research Farm of Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya, Uttar Pradesh, India during Kharif 2021 and 2022. The study aims to determine the effect of crop establishment methods under fertility management on growth parameters of rice. The experiment was laid out in split plot design with three replications. The treatment consisted of four crop establishment methods i.e., (M1) Transplanting rice (Conventional) (M2) Direct seeded rice by line sowing (Conventional) (M3) Drum seeded method under puddled condition,(M4) System of Rice Intensification (SRI) method kept in main plots .However, four nitrogen levels viz, (N1) 100% RDF (150: 60:40 kg N:P:K ha -1), (N2) 75% RDF +25% RDN through FYM, (N3) 75 % RDF + 25% RDN through vermi-compost (VC), (N4) 50 % RDF + 25 % RDN through V.C. + 25% RDN through FYM allotted the in sub plots. This way there was made 16 treatment combinations. As per the results the values of growth, yield and economics viz. plant height (cm), number of tillers m-2, dry matter accumulation (m-2), grain yield (q ha-1) , straw yield (q ha-1), biological yield (q ha-1) , harvest index % and economics of rice were increased significantly with system of rice intensification (SRI) method followed by transplanting method. However, in fertility management the application of 100% RDF [150: 60:40 N: P: K kg ha -1] recorded the maximum plant height, dry matter accumulation, no of tillers, grain yield (q ha-1) , straw yield (q ha-1), biological yield (q ha-1) , harvest index % and economics, which was at par with the application of 75 % RDF + 25% RDN through Vermi- compost and significantly superior over rest of the treatments.
Experiences with Racism Among Asian American Medical Students
Authors: Yang David H. , Justen Marissa , Lee Dana , Kim Heeryoung , Boatright Dowin , Desai Miraj , Tiyyagura Gunjan 
Published: September 2023

ImportanceAsian American physicians have experienced a dual pandemic of racism and COVID-19 since 2020; understanding how racism has affected the learning environment of Asian American medical students is necessary to inform strategies to promoting a more inclusive medical school environment and a diverse and inclusive workforce. While prior research has explored the influence of anti-Asian racism on the experiences of Asian American health care workers, to our knowledge there are no studies investigating how racism has impacted the training experiences of Asian American medical students.ObjectiveTo characterize how Asian American medical students have experienced anti-Asian racism in a medical school learning environment.Design, Setting, and ParticipantsThis qualitative study included online video interviews of Asian American medical students performed between July 29, 2021, and August 22, 2022. Eligible participants were recruited through the Asian Pacific American Medical Students Association and snowball sampling, and the sample represented a disaggregated population of Asian Americans and all 4 medical school years.Main Outcomes and MeasuresThe medical school experiences of Asian American medical students.ResultsAmong 25 participants, Asian ethnicities included 8 Chinese American (32%), 5 Korean American (20%), 5 Indian American (20%), 3 Vietnamese American (12%), 2 Filipino American (8%), and 1 (4%) each Nepalese, Pakistani, and Desi American; 16 (64%) were female. Participants described 5 major themes concerning their experience with discrimination: (1) invisibility as racial aggression (eg, “It took them the whole first year to be able to tell me apart from the other Asian guy”); (2) visibility and racial aggression (“It transitioned from these series of microaggressions that every Asian person felt to actual aggression”); (3) absence of the Asian American experience in medical school (“They’re not going to mention Asian Americans at all”); (4) ignored while seeking support (“I don’t know what it means to have this part of my identity supported”); and (5) envisioning the future.Conclusions and RelevanceIn this qualitative study, Asian American medical students reported feeling invisible within medical school while a target of anti-Asian racism. Addressing these unique challenges related to anti-Asian racism is necessary to promote a more inclusive medical school learning environment.
Single‐Cell RNA Transcriptome of the Human Endometrium Reveals Epithelial Characterizations Associated with Recurrent Implantation Failure
Authors: Zhang Hong , Zhang Chanyu , Zhang Shen 
Published: September 2023

AbstractRecurrent implantation failure (RIF) remains a complex and poorly characterized disorder despite significant advancements in assisted reproductive technology. This study utilizes single‐cell transcriptome sequencing (scRNA‐seq) to characterize the mid‐secretory endometrium of RIF patients. Stromal fibroblast‐enriched and epithelium‐enriched populations are collected using a two‐step dissociation process. After quality control, 25,315 individual cells from 3 RIF patients are analyzed. The analysis identifies 12 distinct cell types, including 6 subtypes of epithelial cells. Significantly, the study reveals the replacement of glandular epithelia with MAP2K6+EPCAMDIM epithelia in the endometrial glands of RIF patients. Furthermore, the study demonstrates that endometrial gland organoids derived from RIF patients exhibit diminished responses to sex steroids compared to the controls. Single‐cell regulatory network inference and clustering (SCENIC) analysis identifies cell‐specific cis‐regulatory elements and constructed regulatory networks in both groups, showing alterations gene‐regulatory networks in RIF patients. Cell‐cell communication analysis distinguishes intercellular communication between the two groups, shedding light on disrupted cellular interactions associated with RIF. In summary, these findings provide valuable insights into the cellular and molecular mechanisms underlying RIF, highlighting the roles of epithelial cells in the implantation process.
Design of Statistical Copolypeptides as Multipurpose Hydrogel Resins in 3D Printing
Authors: Murphy Robert D. , Delaney Colm , Kolagatla Srikanth , Florea Larisa , Hawker Craig J. , Heise Andreas 
Published: September 2023

AbstractHydrogels possess desirable properties for the additive manufacturing of 3D objects, but a significant challenge is to expand the range of hydrogel feedstocks with defined molecular structure and functionality while retaining mechanical properties. To this end, the design of photopolymerizable copolypeptides, derived from linear or star‐shaped architectures which can be tailored to provide control over mechanical properties and associated 3D printing performance, are reported. Based on hydroxy ethyl‐L‐glutamine and vinylbenzyl‐L‐cysteine residues, physical crosslinking via β‐motif assembly is shown to afford hydrogels with viscoelastic properties that allow their use as resins for direct ink writing (DIW) and/or direct laser writing (DLW). The strategic incorporation of vinyl benzyl units permits rapid photocrosslinking of the self‐assembled hydrogels leading to mechanically robust 3D objects. Significantly, copolypeptide architecture directly influences hydrogel resin viscosity, which affords materials with tailorable characteristics for different 3D printing techniques, highlighting the intrinsic versatility of these systems.
Bioengineering Approaches for the Pancreatic Tumor Organoids Research and Application
Authors: Song Taiyu , Kong Bin , Liu Rui , Luo Yuan , Wang Yongan , Zhao Yuanjin 
Published: September 2023

AbstractPancreatic cancer is a highly lethal form of digestive malignancy that poses significant health risks to individuals worldwide. Chemotherapy‐based comprehensive treatment is the primary therapeutic approach for midlife and late‐life patients. Nevertheless, the heterogeneity of the tumor and individual genetic backgrounds result in substantial variations in drug sensitivity among patients, rendering a single treatment regimen unsuitable for all patients. Conventional pancreatic cancer tumor organoid models are capable of emulating the biological traits of pancreatic cancer and are utilized in drug development and screening. However, these tumor organoids can still not mimic the tumor microenvironment (TME) in vivo, and the poor controllability in the preparation process hinders translation from essential drug screening to clinical pharmacological therapy. In recent years, many engineering methods with remarkable results have been used to develop pancreatic cancer organoid models, including bio‐hydrogel, co‐culture, microfluidic, and gene editing. Here, this work summarizes and analyzes the recent developments in engineering pancreatic tumor organoid models. In addition, the future direction of improving engineered pancreatic cancer organoids is discussed for their application prospects in clinical treatment.
The endosymbiotic bacterium Wolbachia (Rickettsiales) alters larval metabolism of the parasitoid Habrobracon hebetor (Hymenoptera: Braconidae)
Authors: Kryukova Natalia A. , Kryukov Vadim Y. , Polenogova Olga V. , Chertkova Еkaterina А. , Tyurin Maksim V. , Rotskaya Ulyana N. , Alikina Tatyana , Kabilov Мarsel R. , Glupov Viktor V. 
Published: September 2023

AbstractInfection of intestinal tissues with Wolbachia has been found in Habrobracon hebetor. There are not many studies on the relationship between Habrobracon and Wolbachia, and they focus predominantly on the sex index of an infected parasitoid, its fertility, and behavior. The actual role of Wolbachia in the biology of Habrobracon is not yet clear. The method of complete eradication of Wolbachia in the parasitoid was developed here, and effects of the endosymbiont on the host's digestive metabolism were compared between two lines of the parasitoid (Wolbachia‐positive and Wolbachia‐negative). In the gut of Wolbachia+ larvae, lipases' activity was higher almost twofold, and activities of acid proteases, esterases, and trehalase were 1.5‐fold greater than those in the Wolbachia– line. Analyses of larval homogenates revealed that Wolbachia+ larvae accumulate significantly more lipids and have a lower amount of pyruvate as compared to Wolbachia– larvae. The presented results indicate significant effects of the intracellular symbiotic bacterium Wolbachia on the metabolism of H. hebetor larvae and on the activity of its digestive enzymes.
Derivation and Internal Validation of aDisease‐SpecificCardiovascular Risk Prediction Model for Patients With Psoriatic Arthritis and Psoriasis
Authors: Colaco Keith , Lee Ker‐Ai , Akhtari Shadi , Winer Raz , Chandran Vinod , Harvey Paula , Cook Richard J. , Piguet Vincent , Gladman Dafna D. , Eder Lihi 
Published: September 2023

ObjectiveTo address suboptimal cardiovascular risk prediction in patients with psoriatic disease (PsD), we developed and internally validated a five‐year disease‐specific cardiovascular risk prediction model.MethodsWe analyzed data from a prospective cohort of participants with PsD without a history of cardiovascular events. Traditional cardiovascular risk factors and PsD‐related measures of disease activity were considered as potential predictors. The study outcome included nonfatal and fatal cardiovascular events. A base prediction model included 10 traditional cardiovascular risk factors. Eight PsD‐related factors were assessed by adding them to the base model to create expanded models, which were controlled for PsD therapies. Variable selection was performed using Least Absolute Shrinkage and Selection Operator (LASSO) penalized regression with 10‐fold cross‐validation. Model performance was assessed using measures of discrimination and calibration and measures of sensitivity and specificity.ResultsBetween 1992 and 2020, 85 of 1,336 participants developed cardiovascular events. Discrimination of the base model (with traditional cardiovascular risk factors alone) was excellent, with an area under the receiver operator characteristic curve (AUC) of 85.5 (95% confidence interval [CI] 81.9–89.1). Optimal models did not select any of the tested disease‐specific factors. In a sensitivity analysis, which excluded lipid lowering and antihypertensive treatments, the number of damaged joints was selected in the expanded model. However, this model did not improve risk discrimination compared to the base model (AUC 85.5, 95% CI 82.0–89.1).ConclusionTraditional cardiovascular risk factors alone are effective in predicting cardiovascular risk in patients with PsD. A risk score based on these factors performed well, indicating excellent discrimination and calibration.image