bluuebunny/crossref_metadata_2025_split huggingface dataset:
Informatics tools to implement late cardiovascular risk prediction modeling for population management of high‐risk childhood cancer survivors
Authors: Noyd David H. , Chen Sixia , Bailey Anna M. , Janitz Amanda E. , Baker Ashley A. , Beasley William H. , Etzold Nancy C. , Kendrick David C. , Kibbe Warren A. , Oeffinger Kevin C. 
Published: June 2023

AbstractBackgroundClinical informatics tools to integrate data from multiple sources have the potential to catalyze population health management of childhood cancer survivors at high risk for late heart failure through the implementation of previously validated risk calculators.MethodsThe Oklahoma cohort (n = 365) harnessed data elements from Passport for Care (PFC), and the Duke cohort (n = 274) employed informatics methods to automatically extract chemotherapy exposures from electronic health record (EHR) data for survivors 18 years old and younger at diagnosis. The Childhood Cancer Survivor Study (CCSS) late cardiovascular risk calculator was implemented, and risk groups for heart failure were compared to the Children's Oncology Group (COG) and the International Guidelines Harmonization Group (IGHG) recommendations. Analysis within the Oklahoma cohort assessed disparities in guideline‐adherent care.ResultsThe Oklahoma and Duke cohorts both observed good overall concordance between the CCSS and COG risk groups for late heart failure, with weighted kappa statistics of .70 and .75, respectively. Low‐risk groups showed excellent concordance (kappa > .9). Moderate and high‐risk groups showed moderate concordance (kappa .44–.60). In the Oklahoma cohort, adolescents at diagnosis were significantly less likely to receive guideline‐adherent echocardiogram surveillance compared with survivors younger than 13 years old at diagnosis (odds ratio [OD] 0.22; 95% confidence interval [CI]: 0.10–0.49).ConclusionsClinical informatics tools represent a feasible approach to leverage discrete treatment‐related data elements from PFC or the EHR to successfully implement previously validated late cardiovascular risk prediction models on a population health level. Concordance of CCSS, COG, and IGHG risk groups using real‐world data informs current guidelines and identifies inequities in guideline‐adherent care.
The blue fluorescence luminescence properties of hyperbranched polysiloxane containing halogen atom
Authors: Jia Yuan , Ma Huan , Yang Juxiang , Ma Mingyang 
Published: June 2023

AbstractIn order to obtain a new class of aggregation‐induced emission (AIE) polymers without common conjugated chromophores in their structures, hyperbranched polysiloxanes (HBPSi) containing halogen elements were obtained by introducing chlorine and bromine atoms into HBPSi (Cl‐HBPSi, Br‐HBPSi) through one‐step polycondensation reaction. The relationship between the chemical structure and fluorescence properties of the two types of HBPSi was studied. The results show that both Cl‐HBPSi and Br‐HBPSi prepared in this study can emit bright blue light under a UV lamp of 365 nm wavelength, and appropriate ratio of raw materials can endow the halogenated HBPSi with moderate degree of polymerization, and give it strong excitation intensity and emission intensity. Meanwhile, Br‐HBPSi exhibits a higher fluorescence intensity, which is due to the ‘heavy atom effect’ of halogen atoms. In addition, for different concentrations of tetrahydrofuran (THF) solutions with the same addition of HBPSi, the luminescence intensity increases gradually with the decrease of THF concentration. These results indicate that the emission intensity is affected by the molecular weight and concentration of polymers, and that the AIE properties of halogenated HBPSi are related to the ‘impurity atomic clusters’ formed by halogenated atoms and the hydroxyl groups formed by the heterogeneity of HBPSi. © 2023 Society of Industrial Chemistry.
Controlling plasma‐activated solution chemistry for targeted cancer cell death
Authors: Liu Zhijie , Tantai Xiamin , Wang Sitao , Pang Bolun , Gao Yuting , Zhang Feng , Zhao Xinyi , Xu Dehui , Soni Aswathi , Mai‐Prochnow Anne , Cullen Patrick , Zhou Renwu 
Published: June 2023

AbstractPlasma‐activated solutions (PAS) are attracting attention in biomedicine, however their complexity necessitates a greater understanding of both the plasma activation process and the selected starting solution. Here, five solutions, including deionized water, saline, PB, PBS, and RPMI 1640, were treated to investigate the physicochemical properties and anticancer effects. The findings show that the different solutions largely affected the gas–liquid interaction reactions and the color penetration distribution of H2O2 and NO2−. The anticancer effects are in the order of DI > PB≈saline> PBS > RPMI 1640, attributed to the important role of H2O2 and NO2− in inactivating cancer cells. This study provides insights into designing and applying PAS in practical anticancer therapy.
Plasma‐treated liquids in medicine: Let's get chemical
Authors: Tampieri Francesco , Gorbanev Yury , Sardella Eloisa 
Published: June 2023

AbstractFundamental and applied research on plasma‐treated liquids for biomedical applications was boosted in the last few years, dictated by their advantages with respect to direct treatments. However, often, the lack of consistent analysis at a molecular level of these liquids, and of the processes used to produce them, have raised doubts of their usefulness in the clinic. The aim of this article is to critically discuss some basic aspects related to the use of plasma‐treated liquids in medicine, with a focus on their chemical composition. We analyze the main liquids used in the field, how they are affected by non‐thermal plasmas, and the possibility to replicate them without plasma treatment.
Mealybug salivary microbes inhibit induced plant defenses
Authors: Zhao Jing , Liu Yongheng , Xu Shouye , Wang Jialu , Zhang Zan , Wang Man‐Qun , Turlings Ted C. J. , Zhang Pengjun , Zhou Aiming 
Published: June 2023

AbstractBACKGROUNDPhenacoccus solenopsis is a polyphagous invasive mealybug that caused serious damage to crops worldwide. Phloem‐sucking hemipterans are known to carry symbiotic microbes in their saliva. However, the role of salivary bacteria of P. solenopsis in modulating plant defenses remains limited. Exploring the impact of salivary bacteria on plant defense responses will contribute to the development of new targets for efficient control of invasive mealybugs.RESULTSSalivary bacteria of the invasive mealybug P. solenopsis can suppress herbivore‐induced plant defenses and thus enhance mealybug fitness. Mealybugs treated with an antibiotic showed decreased weight gain, fecundity and survival. Untreated mealybugs suppressed jasmonic acid (JA)‐regulated defenses but activated salicylic acid (SA)‐regulated defenses in cotton plants. In contrast, antibiotic‐treated mealybugs triggered JA‐responsive gene expression and JA accumulation, and showed shortened phloem ingestion. Reinoculating antibiotic‐treated mealybugs with Enterobacteriaceae or Stenotrophomonas cultivated from mealybug saliva promoted phloem ingestion and fecundity, and restored the ability of mealybugs to suppress plant defenses. Fluorescence in situ hybridization visualization revealed that Enterobacteriaceae and Stenotrophomonas colonize salivary glands and are secreted into the mesophyll cells and phloem vessels. Exogenous application of the bacterial isolates to plant leaves inhibited JA‐responsive gene expression and activated SA‐responsive gene expression.CONCLUSIONOur findings imply that symbiotic bacteria in the saliva of the mealybug play an important role in manipulating herbivore‐induced plant defenses, enabling this important pest to evade induced plant defenses and promoting its performance and destructive effects on crops. © 2023 Society of Chemical Industry.
External amino acid residues of insect GABA receptor channels dictate the action of the isoxazoline ectoparasiticide fluralaner
Authors: Asahi Miho , Yamato Kohei , Ozoe Fumiyo , Ozoe Yoshihisa 
Published: June 2023

AbstractBACKGROUNDFluralaner is the first isoxazoline ectoparasiticide developed to protect companion animals from fleas and ticks. Fluralaner primarily inhibits arthropod γ‐aminobutyric acid receptors (GABARs), which are ligand‐gated ion channels comprising five subunits arranged around the channel pore. We previously reported that the action site of fluralaner resides at the M1–M3 transmembrane interface between adjacent GABAR subunits. To investigate whether fluralaner interacts with the second transmembrane segment (M2) located deep in the interface, we generated four housefly RDL GABAR mutants with non‐conservative amino acid substitutions in the M2 region.RESULTSElectrophysiological analysis of GABARs expressed in Xenopus oocytes indicated that S313A and S314A mutants exhibited fluralaner sensitivities similar to that of the wild type. M312S mutant exhibited approximately seven‐fold lower sensitivity than that of the wild type. Notably, the N316L mutant was almost insensitive to fluralaner.CONCLUSIONThe findings of this study indicate that the conserved external amino acid residues of insect GABAR channels play a critical role in the antagonistic effect of fluralaner. © 2023 Society of Chemical Industry.
A sensitized variable selection control chart based on a classification algorithm for monitoring high‐dimensional processes
Authors: Zhang Shuai , Xue Li , He Zhen , Liu Yumin , Xin Zhongyuan 
Published: June 2023

AbstractDuring the last decade, variable‐selection‐based (VS) control charts have gained much popularity for process monitoring and diagnosis. These charts have been proven efficient for the detection of sparse mean shifts in high‐dimensional processes. VS charts usually assume that in‐control (IC) data are the only information used to determine the control limits. In modern industrial processes, however, out‐of‐control (OC) data can be easily collected. Detecting a specific shift in a data‐rich environment without utilizing OC data information will limit the development of a process monitoring scheme. In this paper, a novel variable selection control chart that is combined with a classification algorithm is proposed, which is expected to benefit from both the classification and variable selection approaches. In contrast to alternative charts, the proposed sensitized variable selection chart can capture the potential shifted variables using both IC and OC information, which can improve the sensitivity of the chart in a specific direction. Extensive Monte Carlo simulations demonstrate that the proposed chart outperforms the alternatives in a data‐rich and high‐dimensional environment. A real‐life example of cellular localization is also included to support the findings of our study.
Exchange Interaction‐Driven Surface State Hybridization in Bi2Se3Topological Insulator
Authors: Kim Jonghoon , Jeong Kwangsik , Park Hanbum , Hong Seokbo , Kim Dajung , Nam Gihwan , Rho Seungwon , Shin Hee Jun , Kang Chul , Cho Mann‐Ho 
Published: June 2023

AbstractTopological insulator has gapless surface state, which results from bulk band inversion due to strong spin–orbit coupling. This nontrivial topology robust to nonmagnetic disorders and defects is considered one of the biggest obstacles for modulations of the surface state. In this work, the suppression of surface properties in Bi2Se3of various thicknesses grown on antiferromagnetic NiO, which has a strong exchange interaction is investigated. Under perpendicular magnetic fields, a drastic decrease in mobilityµand in the number of phase coherent channelsαin 5 QL Bi2Se3on NiO are observed. In addition, the THz transmission study shows that an increase in the surface penetration depthξcan accelerate the hybridization of surface states, which is also verified using the optical pump THz probe. This rapid collapse of surface states indicates the unique role of antiferromagnetic materials in band overlap, suggesting that the topological surface nature can be modulated by forming an antiferromagnet‐topological insulator heterostructure.
Prominin‐1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice
Authors: Matsukuma Haruka , Kobayashi Yuka , Oka Shintaro , Higashijima Fumiaki , Kimura Kazuhiro , Yoshihara Erika , Sasai Noriaki , Shiraishi Koji 
Published: June 2023

AbstractPurposeSpermatogenesis is a complex process orchestrated by several essential genes. Prominin‐1 (Prom1/PROM1) is a gene that is expressed in the testis but with a poorly understood role in spermatogenesis.MethodsWe used Prom1 knockout (Prom1 KO) mice to assess the role of Prom1 in spermatogenesis. To this end, we performed immunohistochemistry, immunofluorescence, western blotting, β‐galactosidase staining, and apoptosis assay. Additionally, we analyzed the morphology of sperm and assessed litter sizes.ResultsWe observed that PROM1 is localized to the dividing spermatocytes in seminiferous epithelial cells, sperm, and columnar epithelium in the epididymis. In the Prom1 KO testis, an aberrant increase in apoptotic cells and a decrease in proliferating seminiferous epithelial cells were observed. Cellular FLICE‐like inhibitory protein (c‐FLIP) and extracellular signal‐regulated kinase 1/2 (ERK1/2) expression were also significantly decreased in Prom1 KO testis. In addition, a significantly increased number of epididymal spermatozoa with abnormal morphology and less motility was found in Prom1 KO mice.ConclusionsPROM1 maintains spermatogenic cell proliferation and survival via c‐FLIP expression in the testis. It is also involved in sperm motility and fertilization potential. The mechanism underlying the effect of Prom1 on sperm morphology and motility remains to be identified.
Commercial drones can provide accurate and effective monitoring of the world's rarest primate
Authors: Zhang Hui , Turvey Samuel T. , Pandey Shree P. , Song Xiqiang , Sun Zhongyu , Wang Nan 
Published: June 2023

AbstractThe recently established Hainan Tropical Rainforest National Park has designated the Hainan gibbon (Nomascus hainanus) as its flagship species, providing new hope for recovery of the last surviving population of the world's rarest primate. However, current monitoring methods are labour‐intensive and only conducted for discrete periods, meaning that detailed information is still lacking on key Hainan gibbon population parameters (such as movement patterns, sleeping site selection and home range size). Alternative monitoring techniques are therefore necessary to supplement traditional methods and provide more accurate estimates of population parameters. Here, we tested whether flying two drones (DJI MAVIC2 Enterprise Advanced), one in the understory and the other above the canopy, could provide new information on Hainan gibbon biology and ecology. During a total of 60 flights, we successfully collected clear RGB and thermal infrared footage of Hainan gibbons. These data provide new baseline information on gibbon movement within the understory and the canopy, their surface body temperatures (23.0–34.7°C), and their movement area during the survey period. The low cost of this equipment could reduce the running costs for Hainan gibbon monitoring. Although drone‐based monitoring has some limitations (e.g. monitoring efficiency could be affected by variation in forest structure and gibbon group size), this new method could complement existing monitoring approaches. Drone‐based monitoring, using multiple drones and a real‐time transmission network, could therefore contribute further towards Hainan Tropical Rainforest National Park's conservation planning for this Critically Endangered primate.
Resource interdependence and successful exit: A configurational perspective on young technology firms
Authors: Pahnke Emily Cox , Sirmon David G. , Rhymer Jen , Campbell Joanna T. 
Published: June 2023

AbstractResearch SummarySuccessful exits are important outcomes for young technology firms. Research has investigated how individual resources affect exit, but both foundational RBV scholarship and newer microfoundations work suggest the need to examine resource configurations in specific contexts. Using an abductive approach and fsQCA methodology, we explore how resource configurations affect exit in the U.S. minimally invasive medical device industry. We find no single resource is necessary or sufficient for exit. Instead, we find four unique equifinal configurations of resources that are sufficient to support exit in certain contexts. Further, these configurations are largely replicated when we distinguish specific exit modes (IPO vs. acquisition). This study advances growing conversations on the role of resource configurations in entrepreneurship with an emphasis on interdependence, complexity, and equifinality of exit.Managerial SummaryNew firms' early resource portfolios are powerful determinants of their future success. No theory exists, however, to predict if or how the combinations of these resources affect young technology ventures' abilities to achieve a successful exit—an outcome important to founders and early investors. In this study, we utilize fsQCA to explore this issue on a sample of startups in a segment of the U.S. medical device industry. We focus on configurations of technological, commercial, social, human, and financial capital as well as the external environment. Our results point to four unique paths that support successful exit. Each configuration includes multiple ingredients for success. This suggests that realizing successful exit is more complex than previously thought as several unique resource configurations support successful exit.
The impact of growth mindset training on entrepreneurial action among necessity entrepreneurs: Evidence from a randomized control trial
Authors: Morris Shad , Carlos Chad , Kistruck Geoffrey M. , Lount Robert B. , Thomas Tumsifu Elly 
Published: June 2023

AbstractResearch SummaryAlthough entrepreneurship training programs are designed to help necessity entrepreneurs acquire skills and capabilities to take entrepreneurial action, participants in these programs often fail to do so. In partnership with a local government agency, we conducted a randomized field experiment involving 165 entrepreneurs in rural Tanzania where in addition to providing technical‐skills training, approximately half of the participants also received “growth mindset” psychological training. Those who received the growth mindset training displayed more entrepreneurial action in their business than those in the control group. Importantly, higher levels of entrepreneurial self‐efficacy mediated the positive impact on entrepreneurial action displayed by participants who received the growth mindset training. We discuss how complementing traditional technical‐based training with growth mindset training can improve the efficacy of entrepreneurship training programs.Managerial SummaryEntrepreneurship training programs often fall short in translating knowledge into action. To address this issue, we conducted an experiment with 165 entrepreneurs in rural Tanzania. All participants received technical‐skills training, but half were also exposed to “growth mindset” training. Those who received the growth mindset training displayed greater initiative in business growth. The newfound confidence and grit they gained empowered them to apply learned principles effectively, ultimately enhancing the effectiveness of entrepreneurship training programs.
Family‐to‐work conflict and instigated incivility: The role of negative affect and family supportive supervisor behaviours
Authors: Rodriguez Wiston A. , Zhou Zhiqing E. , Busse Katlin , Che Xinxuan 
Published: June 2023

AbstractWhile prior research has extensively explored outcomes of family to‐work conflict (FWC), our understanding of how FWC may impact employees' negative interpersonal behaviours at work such as workplace incivility is limited. Given the serious implications of workplace incivility, the current study seeks to understand the relationship between FWC and instigated incivility via the mediating role of negative affect. The moderating role of family supportive supervisor behaviours (FSSB) is also investigated. We collected data from 129 full‐time employees over three waves with six weeks in between. Results revealed that FWC positively predicted instigated incivility, and negative affect mediated this relationship. In addition, the positive effect of FWC on negative affect as well as the indirect effect of FWC on instigated incivility through negative affect were weaker for individuals experiencing more FSSB, suggesting that family related support from supervisors may attenuate the effect of FWC on employees' negative affect and its indirect effect on instigated incivility via negative affect. Theoretical and practical implications are also discussed.
Fugetaxis of Cell‐in‐Catalytic‐Coat Nanobiohybrids in Glucose Gradients
Authors: Rheem Hyeong Bin , Choi Hyunwoo , Yang Seoin , Han Sol , Rhee Su Yeon , Jeong Hyeongseop , Lee Kyung‐Bok , Lee Yeji , Kim In‐San , Lee Hojae , Choi Insung S. 
Published: June 2023

AbstractManipulation and control of cell chemotaxis remain an underexplored territory despite vast potential in various fields, such as cytotherapeutics, sensors, and even cell robots. Herein is achieved the chemical control over chemotactic movement and direction of Jurkat T cells, as a representative model, by the construction of cell‐in‐catalytic‐coat structures in single‐cell nanoencapsulation. Armed with the catalytic power of glucose oxidase (GOx) in the artificial coat, the nanobiohybrid cytostructures, denoted as Jurkat[Lipo_GOx], exhibit controllable, redirected chemotactic movement in response to d‐glucose gradients, in the opposite direction to the positive‐chemotaxis direction of naïve, uncoated Jurkat cells in the same gradients. The chemically endowed, reaction‐based fugetaxis of Jurkat[Lipo_GOx] operates orthogonally and complementarily to the endogenous, binding/recognition‐based chemotaxis that remains intact after the formation of a GOx coat. For instance, the chemotactic velocity of Jurkat[Lipo_GOx] can be adjusted by varying the combination of d‐glucose and natural chemokines (CXCL12 and CCL19) in the gradient. This work offers an innovative chemical tool for bioaugmenting living cells at the single‐cell level through the use of catalytic cell‐in‐coat structures.
Dual‐Defect Engineering of Bidirectional Catalyst for High‐Performing Lithium‐Sulfur Batteries
Authors: Zhou Xiaoya , Cui Yuchen , Huang Xin , Wu Xin , Sun Hao , Tang Shaochun 
Published: June 2023

AbstractPractical applications of lithium‐sulfur (Li‐S) batteries have been hindered by sluggish reaction kinetics and severe capacity decay during charge‐discharge cycling due to the notorious shuttle effect of polysulfide and the unfavored deposition and dissolution of Li2S. Herein, to address these issues, a double‐defect engineering strategy is developed for preparing Co‐doped FeP catalyst containing P vacancies on MXene, which effectively improves the bidirectional redox of Li2S. Mechanism analysis indicates that P vacancy accelerates Li2S nucleation via increased unsaturated sites, and Co doping generates local electric field to reduce the reaction energy barrier and accelerate Li2S dissolution. MXene provides highly conductive channels for electron transport, and effectively captures polysulfide. The double‐defect catalyst enables an impressive reversible specific capacity of 1297.9 mAh g−1 at 0.2 C, and excellent rate capability of 726.5 mAh g−1 at 4 C. Remarkably, it demonstrates excellent cycling stability with capacity retention of 533.3 mAh g−1 after 500 cycles at 2 C. The results can unlock the double‐defect engineering of vacancy induction and heteroatomic doping towards practical Li‐S batteries.