bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambidextrous strategies in turbulent times: the experience of manufacturing SMEs during the COVID-19 pandemic
Authors: Bettiol Marco , Capestro Mauro , Di Maria Eleonora , Micelli Stefano 
Published: December 2022

PurposeThe paper refers to the framework of ambidexterity to explain the strategic paths of manufacturing SMEs in turbulent times, by investigating SMEs' strategic reaction to the COVID-19 pandemic.Design/methodology/approachThe authors adopted an inductive approach methodology. Using a qualitative research method, Italian manufacturing SMEs in different industries were interviewed to outline how they have faced the negative effects of the COVID-19 by considering the strategies implemented during the pandemic.FindingsThe study identifies three ambidextrous strategies for manufacturing SMEs to positively overcome the COVID-19 crisis: (1) playing different roles within the same market (business-to-business and business-to-consumer) simultaneously, (2) simultaneous entrance and management of multiple markets and (3) exploiting manufacturing knowledge for exploring product and business model innovation (simultaneous learning processes).Research limitations/implicationsResults enrich the theoretical discussion on ambidexterity and SMEs, by stressing the strategic dimension of ambidexterity and including a more fine-grained analysis of the different firm’ strategic paths in times of crisis.Practical implicationsThe paper provides practical suggestions for manufacturing SMEs on how they can react during turbulent times and crises by implementing ambidextrous strategies also thanks to the use of digital technologies.Originality/valueThis paper contributes to outlining the conditions for SMEs' resilience in the international competitive context by highlighting the perspective of ambidexterity based on the analysis of multiple case studies from manufacturing industries.
The effect of short-term performance fluctuations on long-term performance: evidence from the English Premier League
Authors: Law Kuok Kei , Yeung Matthew C-H , Chan Jimmy H-T 
Published: December 2022

PurposeThis paper aims to examine the effect of short-term performance fluctuations on long-term performance of football clubs.Design/methodology/approachThis study did not develop any hypothesis for statistical testing. Instead, a database composing of 24 seasons of English Premier Club clubs’ performance was used to analyse for temporal fluctuations of club performance and examined whether such fluctuations would be substantiated in the long run.FindingsFindings showed that club performance exhibited a non-unit root nature, which in turn suggested that clubs’ long-term performance was only temporally affected by short-term performance fluctuations, leading to the evidence that club performance tended to return to the club’s long-run equilibrium after experiencing temporary high or low positions.Originality/valueFindings of this paper provide important information regarding the cost-benefit implications of the reactions of the club management to boost or rectify short-term performance fluctuations by, for example, replacing the club manager or head coach.
Fluid elastic instability and vortex shedding in finned tube arrays: the effects of tube material and fin density
Authors: Yadav Pravin Hindurao , Desai Sandeep R. , Mohanty Dillip Kumar 
Published: December 2022

Purpose
The purpose of this paper is to present investigations on the significant influence of the tube material and fin density on fluid elastic instability and vortex shedding in a parallel triangular finned tube array subjected to water cross flow.

Design/methodology/approach
The experiment was conducted on finned tube arrays with a fin height of 6 mm and fin density of 3 fins per inch (fpi) and 9 fpi. A dedicated setup has been developed to examine fluid elastic instability and vortex shedding. Nine parallel triangular tube arrays with a pitch to tube diameter ratio of 1.78 were considered. The plain tube arrays, coarse finned tube arrays and fine finned tube arrays each of steel, copper and aluminium materials were tested. Plain tube arrays were tested to compare the results of the finned tube arrays having an effective tube diameter same as that of the plain tube.

Findings
A significant effect of fin density and tube material with a variable mass damping parameter was observed on the instability threshold. In the parallel triangular finned tube array subjected to water cross flow, a delay in the instability threshold was observed with an increase in fin density. For steel and aluminium tube arrays, the natural frequency is 9.77 Hz and 10.38 Hz, which is close to each other, whereas natural frequency of the copper tubes is 7.40 Hz. The Connors’ stability constant K for steel and aluminium tube arrays is 4.78 and 4.87, respectively, whereas it is 5.76 for copper tube arrays, which increases considerably compared to aluminum and steel tube arrays. The existence of vortex shedding is confirmed by comparing experimental results with Owen’s hypothesis and the Strouhal number and Reynolds number relationship.

Originality/value
This paper’s results contribute to understand the effect of tube materials and fin density on fluid elastic instability threshold of finned tube arrays subjected to water cross flow.
Digital inclusion and inequalities at work in the age of social media
Authors: Pekkala Kaisa 
Published: December 2022

AbstractAdvancements in digital communication technologies, such as social media, have transformed how individuals can interact inside and outside their organizations and participate in professional life. This qualitative study focuses on inclusion in the increasingly digitalized and interactive workplace. It adopts a managerial perspective and explores whether organizational members are perceived to have equal opportunities to participate and contribute in this novel environment. The research data consists of interviews with 24 managers in seven knowledge‐based organizations. The results show that both individual and organizational factors may become sources of inequality related to digital participation. The findings also emphasize that organizations have an important role in facilitating workers' digital inclusion. The paper contributes to the human resource management and digital inclusion literature and provides important managerial insights for organizations operating in the knowledge sector in particular.
Abelmoschus Manihot ameliorates the levels of circulating metabolites in diabetic nephropathy by modulating gut microbiota in non‐obese diabetes mice
Authors: Shi Ruiya , Tao Yingjun , Tang Haitao , Wu Chenhua , Fei Jingjin , Ge Haitao , Gu Harvest F. , Wu Jie 
Published: December 2022

AbstractHuangkui capsule (HKC), a traditional Chinese medicine, has been used for medication of kidney diseases, including diabetic nephropathy (DN). The current study aimed to evaluate the effects of HKC in the modulation of gut microbiota and the amelioration of metabolite levels by using non‐obese diabetes (NOD) mice with DN. The microbiota from three parts of intestines (duodenum, ileum and colon) in NOD mice with and without HKC treatment were analysed using 16S rDNA sequencing techniques. Untargeted metabolomics in plasma of NOD mice were analysed with liquid mass spectrometry. Results showed that HKC administration ameliorated DN in NOD mice and the flora in duodenum were more sensitive to HKC intervention, while the flora in colon had more effects on metabolism. The bacterial genera such as Faecalitalea and Muribaculum significantly increased and negatively correlated with most of the altered metabolites after HKC treatment, while Phyllobacterium, Weissella and Akkermansia showed an opposite trend. The plasma metabolites, mainly including amino acids and fatty acids such as methionine sulfoxide, BCAAs and cis‐7‐Hexadecenoic acid, exhibited a distinct return to normal after HKC treatment. The current study thereby provides experimental evidence suggesting that HKC may modulate gut microbiota and subsequently ameliorate the metabolite levels in DN.
The Formation of the Jiaodong Gold Province
Authors: DENG Jun , WANG Qingfei , LIU Xuefei , ZHANG Liang , YANG Liqiang , YANG Lin , QIU Kunfeng , GUO Linnan , LIANG Yayun , MA Yao 
Published: December 2022

AbstractGold deposits in Jiaodong, termed Jiaodong‐type, are tectonically located in the southeastern margin of the North China Craton. Their major features are reviewed in this paper to highlight the differences between Jiaodong deposits and other genetic types of gold deposits. The mineralization was synchronized with asthenosphere upwelling indicated by syn‐ore OIB‐like mafic dike and large‐scale crustal thinning suggested by decrease of Sr/Y from pre‐ore to syn‐ore granites. Asthenosphere upwelling induced by the roll‐back of Paleo‐Pacific Plate drove partial melting of lithospheric mantle and devolatilization, which induced the release of the ore‐forming fluids. In concomitant with magmatic records, mineralization migrated from the western Jiaobei terrane (133–127 Ma) to the eastern Sulu orogenic belt (114–108 Ma), corresponding to the eastward roll‐back of Paleo‐Pacific Plate. Gold mineralization in Jiaodong formed in the transitions of ductile to brittle deformation, rapid to slow crustal uplift, and regional compression to extension. In the regional‐scale, the gold deposits in the Jiaobei terrane are mostly situated at intersections between NE‐trending faults and EW‐trending basement faults, and gold orebodies dominantly controlled by the lithologic contacts between Precambrian metamorphic rocks and Mesozoic granites. The mineralization was dominated by the disseminated‐veinlet ores related to quartz–sericite alteration in strong cataclasite‐breccia zone, with subsidiary thick quartz‐sulfide veins developed in secondary fault zones. The ore‐forming fluids belong to a H2O–CO2–NaCl±CH4system and show minor variations in salinity among different types of ore. Structure‐fluid feedback involving fluid‐rock reaction and hydrofracturing triggered the fluid phase separation and resultant gold deposition. The Jiaodong gold deposits are distinct from orogenic and intrusion‐related gold deposits in terms of tectonic setting, origin of ore‐forming fluids, and mechanism of gold deposition.
Extinctions, Morphological Gaps, Major Transitions, Stem Groups, and the Origin of Major Clades, with a Focus on Early Animals
Authors: XIAO Shuhai 
Published: December 2022

AbstractSystematic extinctions can leave major morphological gaps between living crown‐group clades. Such morphological gaps would be perceived, from a neontological point of view, as major evolutionary transitions. In order to fill these morphological gaps and to map the evolutionary steps toward major evolutionary transitions, we need to integrate extinct stem‐group taxa in phylogenetic studies. However, the recognition of stem group has not been widely adopted in the study of early animal fossils, despite that all fossils are stem groups at one level or another. Part of the difficulty is that stem groups may not have all features that collectively diagnose the respective crown group, and they can have unique (autapomorphic) features, making them tantalizingly similar to and frustratingly different from the crown group (e.g., stem‐group eukaryotes can be prokaryotic and stem‐group animals can be protistan). The need to embrace stem groups and to implement the PhyloCode, in order to achieve phylogenetic clarity and to offer key paleontological insights into the origin and early animal evolution, is illustrated in debates on several controversial Ediacaran and Cambrian fossils.
Unresolved early post‐operative pain trajectory predicts moderate‐to‐severe persistent pain after breast cancer surgery—An observational cohort study
Authors: Leblanc Damien , Guichoux Arthur , Sail Marjorie , Boré François , Seegers Valérie , Espitalier Fabien 
Published: December 2022

AbstractBackgroundModelling acute post‐operative pain trajectories may improve the prediction of persistent pain after breast cancer surgery (PPBCS). This study aimed to investigate the predictive accuracy of early post‐operative pain (EPOP) trajectories in the development of PPBCS.Materials & MethodsThis observational study was conducted in a French Comprehensive Cancer Centre and included patients who underwent breast cancer surgery from December 2017 to November 2018. Perioperative and follow‐up data were obtained from medical records, and anaesthesia and perioperative charts. EPOP was defined as pain intensity during the first 24 h after surgery, and modelled by a pain trajectory. K‐means clustering method was used to identify patient subgroups with similar EPOP trajectories. The prevalence of moderate‐to‐severe PPBCS (numeric rating scale ≥4) was evaluated until 24 months after surgery.ResultsA total of 608 patients were included in the study, of which 18% (n = 108) and 9% (n = 52) reported mild and moderate‐to‐severe PPBCS, respectively. Based on EPOP trajectories, we were able to identify a low (64%, n = 388), resolved (30%, n = 182), and unresolved (6%, n = 38) pain group. Multivariate analysis identified younger age, axillary lymph node dissection, and unresolved EPOP trajectory as independent risk factors for moderate‐to‐severe PPBCS development. When compared to patients reporting mild PPBCS, moderate‐to‐severe PPBCS patients experienced significantly more neuropathic pain features, pain‐related interference, and delayed opioid cessation.ConclusionEPOP trajectories can distinguish between resolved and unresolved acute pain after breast cancer surgery, allowing early identification of patients at risk to develop significant PPBCS.
Wearable device for prevention of postoperative and post‐discharge hypoxemia: A randomized pilot trial
Authors: Li Kai , Saab Remie , Bravo Mauro , Mascha Edward J. , Han Yanyan , Nault Rod , Olson Lloyd , Sessler Daniel I. 
Published: December 2022

AbstractBackgroundThe Oxalert Enhanced Pulse Oximeter (EPO) is a wearable device that detects and alerts patients to hypoxemia. In a preplanned pilot trial, we estimated the effect of continuous saturation monitoring with patient alerts on in‐hospital and post‐discharge saturation; we further assessed the feasibility of the intervention.MethodsNoncardiac surgical patients were randomized to either the Oxalert with patient alerts (Monitor + Alert, N = 25) or the Oxalert without patient alerts (Monitor Only, N = 24). Monitoring continued during hospitalization for up to 6 days and for 24 h after hospital discharge. Patients in each group were compared on time‐weighted average (TWA) SpO2 <90% (%) and area under SpO2 <90% (% * min) in‐hospital and after discharge using the Wilcoxon rank sum test, with the treatment effect median difference and 95% confidence interval (CI) estimated using the Hodges–Lehmann estimator of location shift.ResultsWe enrolled ≥2 patients per week, for a total of 49 patients in whom recording were obtained for a median [quartiles] of 91 [85, 95]% of the time in hospital. In‐hospital, TWA SpO2 <90% was a median [quartiles] of 0.11 [0.03, 0.25]% for Monitor + Alert and 0.29 [0.04, 0.71]% for Monitor‐Only patients, with estimated median difference (95% CI) of −0.1 (−0.4, 0)%, p = .120. In hospital, the area under the curve (AUC) SpO2 <90% was a median [quartiles] of 635 [204, 1513] % * min for Monitor + Alert and 1260 [117, 5278] % * min for Monitor‐Only patients, with estimated median difference (95% CI) of −407 (−1816, 208) % * min, p = .349. Post‐discharge, the estimated median difference (95% CI) was only −0.1 (−0.2, 0) %, p = .307.ConclusionsThe Oxalert system was well tolerated in both groups and enrollment was strong. Patients randomized to active Oxalert systems experienced half as many postoperative desaturation events while hospitalized, although the difference was not statistically significant in this small pilot trial. In contrast, the Oxalert system did not reduce post‐discharge desaturation. Detecting postoperative deterioation in surgical patients after they arrive on regular hospital wards, and even after they have been discharged home, can potentially facilitate necessary “rescue” interventions. Wearable devices assessing vital signs, including oxygenation, are a practical requirement. In this pilot study, a wearable pulse oximeter, with and without hypoxemia alarms, was tested for feasibility and acceptability for signal collection in postoperative cases, including at home. Results indicate that a full‐scale trial is warranted to test for possible clinical benefit with this type of “wearable” where late postoperative hypoxia could be a concern. The trial was registered at ClincialTrial.gov (NCT04453722).
Positive oral health outcomes: A partnership model improves care in a rural Indigenous community
Authors: Mangoyana Clare , March Sandra , Lalloo Ratilal , Walsh Laurence J. 
Published: December 2022

AbstractObjectiveThe purpose of this study was to explore the benefits of a partnership between a university dental school and a Community Controlled Health Service, specifically in relation to improving the oral health of an underserved rural Indigenous community. We sought community opinions on health and social outcomes arising from the service provided by the dental student clinical outplacement.SettingIn Dalby, Queensland.ParticipantsIn total, 38 participants in five focus groups were representative of local Indigenous community Elders, community health support group members and management and staff.DesignA descriptive qualitative study employing semi‐structured audio‐recorded focus group discussions conducted with purposefully selected Indigenous community groups to explore participant views and experience of the partnership model. Qualitative data were analysed using thematic content analysis.ResultsThe Indigenous community representatives expressed positive benefit in both their general and oral health awareness, in improved access to dental care provided in their own safe space, while they were pleased to assist with students' learning. They viewed the partnership as mutually beneficial. Suggestions for enhancement of the oral health service were also offered.ConclusionThis partnership between a university and a Community Controlled Health Service provides sustainable positive social and health benefits for the targeted Indigenous community and for the wider local population, while simultaneously providing enhanced educational benefits for students on clinical outplacement. Translation and uptake of this successful model of care would benefit both underserved communities and dental and other health care professional educators worldwide.
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signalling
Authors: Zhang Zhirui , Wu Wei , Jiao Hao , Chen Yuzhong , Ji Xiaojun , Cao Jing , Yin Fangzhou , Yin Wu 
Published: December 2022

Background and PurposeSqualene epoxidase (SQLE) is a key enzyme involved in cholesterol biosynthesis, but growing evidence also reveals that SQLE is abnormally expressed in some types of malignant tumours, even though the underlying mechanism remains poorly understood.Experimental ApproachBioinformatics analysis and RNA sequencing were applied to detect differentially expressed genes in clinical hepatocellular carcinoma (HCC). MTT, colony formation, AnnexinV‐FITC/PI, EdU, wound healing, transwell, western blot, qRT‐PCR, IHC, F‐actin, RNA‐sequencing, dual‐luciferase reporters, and H&E staining were used to investigate the pharmacological effects and possible mechanisms of SQLE.Key ResultsSQLE expression was specifically elevated in HCC, correlating with poor clinical outcomes. SQLE significantly promoted HCC growth, epithelial–mesenchymal transition, and metastasis both in vitro and in vivo. RNA sequencing and functional experiments revealed that the protumourigenic effect of SQLE on HCC was closely related to the activation of TGF‐β/SMAD signalling, but the stimulatory effect of SQLE on TGF‐β/SMAD signalling and HCC development is critically dependent on STRAP. SQLE expression is well correlated with STRAP in HCC, and further, to amplify TGF‐β/SMAD signalling, SQLE even transcriptionally increased STRAP gene expression mediated by AP‐2α. Finally, as a chemical inhibitor of SQLE, NB‐598 markedly inhibited HCC cell growth and tumour development.Conclusions and ImplicationsTaken together, SQLE serves as a novel oncogene in HCC development by activating TGF‐β/SMAD signalling. Targeting SQLE could be useful in drug development and therapy for HCC.
Talking with machines: Can conversational technologies serve as children's social partners?
Authors: Xu Ying 
Published: December 2022

AbstractBack‐and‐forth conversations with others are vital for children's development in the early years. While children's conversation partners have traditionally been their parents, teachers, and peers, recent advances in artificial intelligence have led to the introduction of machines that understand human speech and generate natural responses, and thus can engage children in conversations. As these technologies become increasingly ubiquitous in children's lives, questions arise as to how they might affect children's development: How do children interact with, perceive, and learn from conversational technologies? Can these technologies serve as children's social partners? In this article, I detail what we know about these topics and discuss the possible implications of conversational technologies for children's shifting media landscape. I also suggest research agendas that can unpack the complex interplay among children, their social contexts, and conversational technology.
Holocaust communication, attachment orientation and distress among descendants of female holocaust survivors
Authors: Lishner Freud Eve , Berant Ety 
Published: December 2022

AbstractThe multiple studies that have examined the transgenerational transmission of Holocaust trauma from survivors to their descendants have yielded inconsistent results. These can be attributed to differences in assessment tools and to individual differences between survivors, such as their specific experiences during the Holocaust. This study examined the differences between daughters and granddaughters of female Holocaust survivors (HS) of concentration camps (CCS) versus survivors of other circumstances (ghettos, concealment, etc.; OCCS) in terms of communication about their mothers' or grandmothers' Holocaust trauma (Holocaust communication), their attachment orientations, and their psychological distress. The sample was composed of 79 dyads of daughters of HS and their own daughters, divided into two groups according to the survivors' Holocaust experiences (CCS—47 dyads; OCCS—32 dyads). The findings indicated that daughters of CCS reported a higher number of conversations about the Holocaust with their mothers, perceived their mothers as more distant during Holocaust communication, and reported more guilt feelings than daughters of OCCS. Holocaust communication between daughters and granddaughters was characterized by shorter conversations, and granddaughters perceived their mothers as sadder in the CCS group than in the OCCS group. No difference between groups was found in Holocaust communication between survivors and their granddaughters. No difference was found between groups in their psychological distress. The granddaughters of CCS scored higher on attachment anxiety than the other group. Most of the significant differences between groups were linked to subtle differences in the characteristics of communication and in the inter‐personal sphere.