bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information set supported deep learning architectures for improving noisy image classification
Authors: Bhardwaj Saurabh , Wang Yizhi , Yu Guoqiang , Wang Yue 
Published: March 2023

AbstractDeep learning models have been widely used in many supervised learning applications. However, these models suffer from overfitting due to various types of uncertainty with deteriorating performance when facing data biases, class imbalance, or noise propagation. The Information-Set Deep learning (ISDL) architectures with four variants are developed by integrating information set theory and deep learning principles to address the critical problem of the absence of robust deep learning models. There is a description of the ISDL architectures, learning algorithms, and analytic workflows. The performance of the ISDL models and standard architectures is evaluated using a noise-corrupted benchmark dataset. The experimental results show that the ISDL models can efficiently handle noise-dominated uncertainty and outperform peer architectures.
Fabrication of nitrogen doped TiO2/Fe2O3 nanostructures for photocatalytic oxidation of methanol based wastewater
Authors: Mersal Mai , Zedan Abdallah F. , Mohamed Gehad G. , Hassan Gamal K. 
Published: March 2023

AbstractAn important industrial process that often occurs on the surface of a heterogeneous catalyst using thermochemical or photochemical could help in the oxidation of methanol-based wastewater to formaldehyde. Titania-based photocatalysts have drawn a lot of interest from scientists because they are a reliable and affordable catalyst material for photocatalytic oxidation processes in the presence of light energy. In this study, a straight-forward hydrothermal method for producing n-TiO2@α-Fe2O3 composite photocatalysts and hematite (α-Fe2O3) nanocubes has been done. By adjusting the ratio of n-TiO2 in the prepared composite photocatalysts, the enhancing influence of the nitrogen-doped titania on the photocatalytic characteristics of the prepared materials was investigated. The prepared materials were thoroughly characterized using common physiochemical methods, such as transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction (XRD), energy dispersive X-ray (EDX), X-ray photoelectrons spectroscopy (XPS), physisorption (BET), and others, in order to learn more about the structure The results obtained showed that nitrogen-doped titania outperforms non-doped titania for methanol photooxidation. The addition of nitrogen-doped titania to their surfaces resulted in an even greater improvement in the photooxidation rates of the methanol coupled with hematite. The photooxidation of methanol in the aqueous solution to simulate its concentration in the wastewater has been occurred. After 3 h, the four weight percent of n-TiO2@α-Fe2O3 photocatalyst showed the highest rate of HCHO production.
Neuromodulatory effect of 4-(methylthio)butyl isothiocyanate against 3-nitropropionic acid induced oxidative impairments in human dopaminergic SH-SY5Y cells via BDNF/CREB/TrkB pathway
Authors: Kaur Prabhjot , Attri Shivani , Singh Davinder , Rashid Farhana , Singh Sharabjit , Kumar Avinash , Kaur Harjot , Bedi Neena , Arora Saroj 
Published: March 2023

AbstractMitochondrial impairment, energetic crisis and elevated oxidative stress have been demonstrated to play a pivotal role in the pathological processes of Huntington’s disease (HD). 3-Nitropropionic acid (3-NPA) is a natural neurotoxin that mimics the neurological dysfunctions, mitochondrial impairments and oxidative imbalance of HD. The current investigation was undertaken to demonstrate the neuroprotective effect of 4-(methylthio)butyl isothiocyanate (4-MTBITC) against the 3-NPA induced neurotoxicity in human dopaminergic SH-SY5Y cells. The experimental evidence of oxidative DNA damage by 3-NPA was elucidated by pBR322 DNA nicking assay. In contrast, the 4-MTBITC considerably attenuated the DNA damage, suggesting its free radical scavenging action against 3-NPA and Fenton's reagent. The dose and time-dependent increase of 3-NPA revealed its neurotoxic dose as 0.5 mM after 24 h of treatment of SH-SY5Y cells in MTT assay. In order to determine the optimal dose at which 4-MTBITC protects cell death, the 3-NPA (IC50) induced cells were pretreated with different concentrations of 4-MTBITC for 1 h. The neuroprotective dose of 4-MTBITC against 3-NPA was found to be 0.25 μM. Additionally, the elevated GSH levels in cells treated with 4-MTBITC indicate its propensity to eliminate reactive species generated as a result of 3-NPA-induced mitochondrial dysfunction. Likewise, it was determined through microscopic and flow cytometric experiments that 3-NPA's induced overproduction of reactive species and a decline in mitochondrial membrane potential (MMP) could be efficiently prevented by pre-treating cells with 4-MTBITC. To elucidate the underlying molecular mechanism, the RT-qPCR analysis revealed that the pre-treatment of 4-MTBITC effectively protected neuronal cells against 3-NPA-induced cell death by preventing Caspase-3 activation, Brain-derived neurotrophic factor (BDNF) upregulation, activation of cAMP response element-binding protein (CREB) and Nrf2 induction. Together, our findings lend credence to the idea that pre-treatment with 4-MTBITC reduced 3-NPA-induced neurotoxicity by lowering redox impairment, apoptotic state, and mitochondrial dysfunction. The present work, in conclusion, presented the first proof that the phytoconstituent 4-MTBITC supports the antioxidant system, BDNF/TrkB/CREB signaling, and neuronal survival in dopaminergic SH-SY5Y cells against 3-NPA-induced oxidative deficits.
Bloch points and topological dipoles observed by X-ray vector magnetic tomography in a ferromagnetic microstructure
Authors: Hermosa Javier , Hierro-Rodríguez Aurelio , Quirós Carlos , Martín José I. , Sorrentino Andrea , Aballe Lucía , Pereiro Eva , Vélez María , Ferrer Salvador 
Published: March 2023

AbstractBloch points are small 3D magnetic textures with unit topological charge that require the use of advanced vector imaging techniques for their direct experimental characterization. Here we show results from the reconstruction of the magnetization field $${{{{{\bf{m}}}}}}\left({{{{{\bf{r}}}}}}\right)$$
m

r

of an elongated permalloy microstructure by X-ray vector magnetic tomography. A central asymmetric Bloch domain wall is observed, decorated by Bloch points arranged in several dipoles and a triplet. The analysis of the $${{{{{\bf{m}}}}}}\left({{{{{\bf{r}}}}}}\right)$$
m

r

map in terms of topological concepts provides a quantitative description of the Bloch points as topological monopoles connected by bundles of emergent magnetic field lines carrying a fractional topological flux. It also reveals the topological constraints that determine chirality transitions of the central domain wall in the vicinity of Bloch points, independent of specific material properties. This approach could be readily extended to the study of magnetic microstructures in arbitrary remanent configurations.
Residual dipolar couplings as a tool for structural analysis of ionic liquids
Authors: de Melo Higor D. F. , Carvalho Daiane S. , Hallwass Fernando , Sternberg Ulrich , Navarro-Vázquez Armando 
Published: March 2023

Swelling of an acrylonitrile/N-N-dimethylacrylamide copolymer in ionic liquids provides residual dipolar couplings which are applied to conformational analysis of the bulk ionic liquid.
Evolution and functional diversification of yeast sugar transporters
Authors: Donzella Lorena , Sousa Maria João , Morrissey John P. 
Published: March 2023

Abstract
While simple sugars such as monosaccharides and disaccharide are the typical carbon source for most yeasts, whether a species can grow on a particular sugar is generally a consequence of presence or absence of a suitable transporter to enable its uptake. The most common transporters that mediate sugar import in yeasts belong to the major facilitator superfamily (MFS). Some of these, for example the Saccharomyces cerevisiae Hxt proteins have been extensively studied, but detailed information on many others is sparce. In part, this is because there are many lineages of MFS transporters that are either absent from, or poorly represented in, the model S. cerevisiae, which actually has quite a restricted substrate range. It is important to address this knowledge gap to gain better understanding of the evolution of yeasts and to take advantage of sugar transporters to exploit or engineer yeasts for biotechnological applications. This article examines the full repertoire of MFS proteins in representative budding yeasts (Saccharomycotina). A comprehensive analysis of 139 putative sugar transporters retrieved from 10 complete genomes sheds new light on the diversity and evolution of this family. Using the phylogenetic lens, it is apparent that proteins have often been misassigned putative functions and this can now be corrected. It is also often seen that patterns of expansion of particular genes reflects the differential importance of transport of specific sugars (and related molecules) in different yeasts, and this knowledge also provides an improved resource for the selection or design of tailored transporters.
Velocity‐free formation control for omnidirectional mobile robots with input saturation
Authors: Jia Yuxin , Jia Yingmin , Gong Kai , Zheng Wenhao 
Published: March 2023

AbstractThis paper presents a command‐filter‐based formation control scheme for the leader‐follower omnidirectional mobile robots (OMRs) subject to the absence of the velocity measurements, input saturation and unknown bounded disturbances. First, an adaptive velocity observer is designed based on a novel state transformation of the OMR dynamics. Then, a finite‐time command filtering strategy is proposed, where the Levant filter is used to estimate the time derivative of the virtual control law, and an error compensator with finite time convergence is constructed to eliminate the filtering error correspondingly. Moreover, the anti‐saturation module and adaptive law are designed to attenuate the influence caused by input saturation and external disturbances. The proposed control scheme can ensure that all signals of the closed‐loop system including the formation error are uniformly bounded, and the effectiveness is verified by the simulations results.
Efficient waveguide power combiners at mm‐wave frequencies
Authors: van Schelven Ralph M. , Spirito Marco , Cavallo Daniele 
Published: March 2023

AbstractIn this study, an efficient power combiner for mm‐wave frequency transmitters is investigated. The combiner is based on a parallel plate waveguide (PPW) excited with multiple parallel feeds. The Doherty power combiner scheme is also integrated in the proposed concept, to increase the efficiency of the amplifiers when implementing amplitude modulation. The advantage of the proposed PPW combiner with respect to other concepts, for example, the ones based on substrate‐integrated waveguide, is the wider bandwidth and the scalability to an arbitrary number of inputs. Measured results from a demonstrator realised in standard printed circuit board technology are presented. Two variations of the combiner are implemented, one terminated with a 50 Ω coaxial output, and another integrated with an antenna. In the latter case, the waveguide is folded so that both the power combiner and the antenna fit within a half wavelength size, and thus would be compatible with a dense antenna array implementation.
Optimal selection of single tuned passive filters to enhance post‐fault voltage recovery and power quality in a renewable integrated microgrid
Authors: Ahmed Mushfiqul , Masood Nahid‐Al , Aziz Tareq 
Published: March 2023

AbstractThe harmonic currents produced by nonlinear loads and renewable energy sources (RES) like PV and wind energy have had a growing impact on industrial distribution networks in recent times. Along with harmonic distortions, lack of adequate reactive power support in a heavily loaded renewable‐rich industrial network has made the operation vulnerable to fault‐induced delayed voltage recovery (FIDVR). Due to poor post‐fault voltage recovery, an industrial microgrid is exposed to cascading loss of distributed generators (DGs). Dynamic var sources are being used to prevent cascade tripping. However, they may result in deterioration of the network's THD scenarios. Single tuned passive filters are widely used to suppress harmonic contents. The goal of this work is to design filters so that these become capable to lower overall harmonic distortion while also minimizing the risk of blackouts caused by inadequate post‐fault voltage recovery. To determine the allocation and rating of single tuned passive filters in a renewable‐penetrated industrial microgrid, an optimization model is developed. To show the feasibility and efficacy of the proposed formulation, simulations are performed on a modified IEEE 43 bus system. The findings suggest that the proposed design methodology produces effective solutions to minimize the necessity of additional reactive power sources.
Fast GPU based acquisition with minimum loss and downsampling techniques for weak BeiDou SBAS signals
Authors: Tang Chengyao , Chen Lei , Lv Zhicheng , Xie Fang , Mou Weihua 
Published: March 2023

AbstractFor a receiver of the BeiDou Satellite Based Augmentation System (BDSBAS), the acquisition aims to coarsely estimate the pseudo‐code delays and carrier Doppler shifts of the received signals. The use of downsampling techniques to accelerate this acquisition process for weak signals has been an emerging topic. However, the acquisition probabilities of conventional algorithms with downsampling are inadequate and need to be enhanced to prevent excessive false alarms due to degradation of the peak signal‐to‐noise ratios (PSNRs) during acquisition. To improve signal acquisition performance, we introduce an enhancer function before downsampling to achieve the minimum PSNR loss during acquisition. Then, we use graphic processing unit (GPU) functions to speed up the processing loop, matrix multiplication and fast Fourier transform operations. We thus present a fast GPU‐based acquisition method by using minimum loss and downsampling techniques. Our experimental results show the remarkable effectiveness of our method for receiving weak BDSBAS signals as compared to legacy downsampling algorithms. This work seeks not only to solve the current issue of achieving fast acquisition of weak BDSBAS signals but also to inspire creative new ideas that spur further advances in this promising field in the future.
Lower Extremity Reconstruction with Anterolateral Thigh Free-Flap Anastomoses: A Computational Fluid Dynamic Analysis
Authors: Jinka Sanjay K.A. , Jinka Ashoka G.K. , Janis Jeffrey E. 
Published: March 2023

Abstract
Background The anterolateral thigh free flap is an option for repairing soft tissue defects of the distal lower extremity. This flap uses the descending branch of the lateral circumflex femoral (LCF) artery as the flap vessel. The recipient vessel in these flaps is often the anterior tibial (AT), posterior tibial (PT), or peroneal (P) arteries. Computational fluid dynamic (CFD) evaluation of anastomoses between these vessels can optimize outcomes.
Methods Thirty-eight CFD models were created to model end-to-side (ETS) and end-to-end (ETE) anastomoses for lower extremity reconstruction. Seven out of thirty-eight models represented ETS anastomoses between the LCF and AT arteries with varying anastomotic angles. Nine out of thirty-eight models represented 45-degree ETS anastomoses between varying diameters of the LCF and AT, PT, and P arteries. Nine out of thirty-eight models represented stenosis on the flap vessel and recipient vessel, pre- and post-bifurcation. Nine out of thirty-eight models represented ETE anastomoses, rather than ETS, with varying vessel diameters. Four out of thirty-eight models represented ETE anastomoses with varying regions and levels of stenosis.
Results Stasis of blood flow in ETS models increased as anastomotic angle increased in a logarithmic relationship (R
2 = 0.918). Flow was optimized overall as flap and recipient vessel diameters approached one another. In ETS models, flap vessel and postbifurcation recipient vessel stenosis were found to substantially increase stasis.
Conclusion Selection of flap and recipient vessels with similar diameters can optimize outcomes in microvascular anastomoses. In the context of lower extremity reconstruction with the ALT flap, the PT artery can be recommended as a first-line recipient vessel due to its similar vessel caliber to the LCF and relative ease of surgical access compared with the P artery. Avoidance of areas of stenosis is recommended to ensure laminar flow and reduce the operative difficulty associated with performing anastomoses on nonpliable arteries. Striving for increased acuity of anastomotic angles is recommended to optimize the flow in ETS microvascular anastomoses.
Trends of Autologous Free-Flap Breast Reconstruction and Safety during the Coronavirus Disease 2019 Pandemic
Authors: Elmer Nicholas A. , Bustos Valeria P. , Veeramani Anamika , Hassell Natalie , Comer Carly D. , Manstein Samuel M. , Kinney Jacquelyn , Lee Bernard T. , Lin Samuel J. 
Published: March 2023

Abstract
Background Autologous free-flap breast reconstruction (ABR) is a valuable surgical option for patients following mastectomy. The coronavirus disease 2019 (COVID-19) pandemic has led to a myriad of factors that have affected access to care, hospital logistics, and postoperative outcomes. This study aims to identify differences in patient selection, hospital course and severity, and postoperative outcomes for patients who underwent ABR during and prior to the COVID-19 pandemic.
Methods Patients undergoing ABR from the American College of Surgeons National Surgical Quality Improvement Program 2019 to 2020 database were analyzed to compare sociodemographics, hospital course, and outcomes over the first postoperative month. Multivariable logistic regression was used to identify factors predictive of complications based on the operative year.
Results In total, 3,770 breast free flaps were stratified into two groups based on the timing of reconstruction (prepandemic and pandemic groups). Patients with a diagnosis of disseminated cancer were significantly less likely to undergo ABR during the COVID-19 pandemic. On univariate analysis, there were no significant differences in postoperative complications between the two groups. When controlling for potentially confounding sociodemographic and clinical risk factors, the COVID-19 group was significantly more likely to undergo reoperation compared with the prepandemic group (p < 0.05).
Conclusion When comparing outcomes for patients who underwent ABR prior to and during the COVID-19 pandemic, we found a significant increase in the odds of reoperation for those who had ABR during the pandemic. Debridement procedures and exploration for postoperative hemorrhage, thrombosis, or infection increased in the prepandemic group compared to the COVID-19 group. Notably, operative times decreased.
Visual Perception of Breast Free Flap Size Is Influenced by Radiation Changes of Surrounding Tissue
Authors: Lu Yi-Hsueh , Wang Fei , Rothchild Evan , Greige Nicolas , Mehta Karan , Weichman Katie E. , Ricci Joseph A. 
Published: March 2023

Abstract
Background Microsurgical reconstruction for bilateral mastectomy defects after unilateral radiation often results in asymmetry, despite both flap tissues never being radiated.
Methods Photos of 16 patients who received prior radiation to one breast and underwent bilateral abdominal free flap reconstruction were taken postoperatively. Layperson and expert assessment were attained via online crowdsourcing and a panel of attending surgeons and senior residents. Stratification by interflap weight differences was done for subanalysis.
Results A total of 399 laypersons responded, with the majority (57.3%) reporting that the radiated breast appeared smaller than the nonradiated breast. When the photos were stratified by interflap weight differences, the photos with the radiated side flap weight over 3% more than nonradiated side were significantly more likely to be perceived by laypersons as the same size (odds ratio [OR] = 2.7; p < 0.001) and of similar aesthetic (OR = 1.9; p < 0.001) when compared with photos with same-sized flaps. Of the expert responses (n = 16), the radiated side was perceived as smaller 72.3% of the time and the nonradiated side appeared more aesthetic 52.7% of the time. Contrary to layperson responses, the experts tend to report the radiated side as smaller despite varying flap weight. Interestingly, expert raters were significantly more likely to rate the flaps of equal aesthetics when the radiated side has a flap larger by 3% or more (OR = 3.6; p < 0.001).
Conclusion Higher aesthetic scores were noted when larger flaps were inset to the radiated envelope by both laypersons and experts, suggesting potential technical refinement in reconstructive outcomes.
Pd(II)-Catalyzed Directing-Group-Aided C–H Arylation, Alkylation, Benzylation, and Methoxylation of Carbazole-3-carboxamides toward C2,C3,C4-Functionalized Carbazoles
Authors: Babu Srinivasarao Arulananda , Kaur Ramandeep , Singh Harcharan 
Published: March 2023

AbstractWe report the Pd(II)-catalyzed β-C–H arylation, alkylation, benzylation, and methoxylation of carbazole-3-carboxamide and carbazole-2-carboxamide substrates, assisted by the bidentate directing groups 8-aminoquinoline or 2-(methylthio)aniline, and construction of C2,C3,C4-functionalized carbazole motifs. The Pd(II)-catalyzed β-C–H arylation reaction was attempted using different directing groups such as 8-aminoquinoline, 2-(methylthio)aniline, 4-amino-2,1,3-benzothiadiazole, 4-methoxyquinolin-8-amine, and butan-1-amine. Through optimization of the reactions, 8-aminoquinoline and 2-(methylthio)aniline were found to be suitable directing groups and, especially, 2-(methylthio)aniline was found to be an efficient directing group in the Pd(II)-catalyzed β-C–H arylation, alkylation, and methoxylation of carbazole-3-carboxamide, carbazole-2-carboxamide substrates. An ample number of β-C–H arylated, alkylated, benzylated, and methoxylated carbazole-3-carboxamides were synthesized. The structures of representative β-C(2)–H arylated carbazole and β-C(2)–H methoxylated carbazole motifs were unequivocally confirmed by single-crystal X-ray structure analysis. Given the wide range of applications of carbazoles in chemistry, materials sciences, and medicinal chemistry and there have been constant efforts for developing new methods for synthesizing functionalized carbazoles. This work contributes to the expansion of the library of C2,C3,C4-functionalized carbazole motifs through a Pd(II)-catalyzed directing-group-aided site-selective β-C–H activation and functionalization of carbazole-3-carboxamides.