bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active learning and education 4.0 for complex thinking training: analysis of two case studies in open education
Authors: Patiño Azeneth , Ramírez-Montoya María Soledad , Buenestado-Fernández Mariana 
Published: January 2023

AbstractThis article focuses on empirically analyzing the final products designed by 147 academics from 11 countries who participated in an international open education movement workshop by answering the research questions “What are the techno-pedagogical components of the products designed by the participants to encourage the open educational movement? and what practice of the open educational movement is being executed?” The article starts with a conceptual basis that describes the concepts of Active learning, Education 4.0, Complex Thinking and Open Education. It presents (1) the case study methodology on which this research is based, (2) two case studies on open education, (3) a game-based intervention proposal to support instructors in training university students in complex thinking skills based on Education 4.0 technologies and game-based learning principles, (4) and a discussion of the findings and opportunities for further work in the area. The findings of this study reveal that (A) the use of emerging and 4.0 technologies in initiatives of the open education movement continue to increase; (B) most of the open education initiatives designed by academics participating in the workshops were focused on the production of OER; and (C) inclusive access to education and continuing professional development of teachers is a constant concern addressed in open education initiatives. The results of this research suggest that training and development interventions implying the creation or design of open education initiatives should focus on encouraging all kinds of open education practices (i.e. use, production, dissemination and mobilization).
Pivot shift intraoperative quantitative assessment using a smartphone accelerometer in ACL deficient knees
Authors: Soudé Guillaume , De Villeneuve Bargemon Jean‐Baptiste , Khakha Raghbir , Pithioux Martine , Argenson Jean‐Noël , Ollivier Matthieu , Jacquet Christophe 
Published: January 2023

AbstractPurposeThe Pivot Shift (PS) test is a complex clinical sign that assesses the internal rotation and anterior tibial translation, which occurs abnormally in ACL deficient‐knees. Because of the high inter‐observer variability, different devices have been designed to characterize this complex movement in quantitative variables. The objective of this pilot study is to validate the reproducibility of intraoperative quantitative assessment of the PS with a smartphone accelerometer.MethodsTwelve ACL‐injured knees were included and compared with the contralateral uninjured side. The PS was measured by two independent observers utilizing a smartphone accelerometer and graded according to the IKDC classification. Measurements were taken preoperatively, intraoperatively and postoperatively. Intraoperative readings were taken during each stage of reconstruction or repair of meniscoligamentous lesions including meniscal lesions, ramp lesions, ACL reconstruction and lateral tenodesis. Reproducibility of the measurements were evaluated according to an intraclass correlation coefficient (ICC).ResultsThe intra‐observer reliability was good for the first examiner and excellent for the second examiner, with the ICC 0.89 [0.67, 0.98] p < 0,001 and ICC 0.97 [0.91, 1.0] p < 0,001 respectively. The inter‐observer reliability was excellent between the two observers with the ICC 0.99 [0.97, 1.0] p < 0,001. The mean tibial acceleration measured 3.45 m.s2 (SD = 1.71) preoperatively on the injured knees and 1.03 m.s2 (SD = 0.36) on the healthy knees, demonstrating a significant difference following univariate analysis p < 0.001. Postoperatively, no significant difference was observed between healthy and reconstructed knees The magnitudes of tibial acceleration values were correlated with the PS IKDC grade.ConclusionThe smartphone accelerometer is a reproducible device to quantitatively assess the internal rotation and anterior tibial translation during ACL reconstruction surgery. The measurements are influenced by the different surgical steps. Other larger cohort studies are needed to evaluate the specific impact of each step of the ACL reconstruction and meniscal repair on this measurement. An external validation using other technologies are needed to validate the reliability of this device to assess the PS test.Level of evidenceLevel IV, case series, pilot study.
Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles
Authors: Wang Zeng-Yan , Huang Shu-Xing , Yang Jing-Di , Li Dan-Ping , Xu Yan-Wen 
Published: January 2023

Objective: To analyze the pregnancy outcomes of patients presenting with infertility solely due to diminished ovarian reserve (DOR) and treated by assisted reproductive technology (ART), including artificial insemination by husband (AIH) and in vitro fertilization (IVF).
Methods: This was a retrospective study of subfertile patients due to DOR attending the Center for Reproductive Medicine in Guangzhou, China, between January 2010 and October 2015. Patients were assigned into either the AIH or IVF group. Within each group, these patients were further subgrouped based on their serum basal follicle-stimulating hormone (bFSH) level (10 ≤ bFSH ≤ 12IU/L and bFSH > 12IU/L) and age (20–30, 31–35, 36–40, and 41–45 years). The live birth rates were compared among these groups and subgroups.
Results: A total of 1,003 patients with a median age of 38.91 (21–45) years were enrolled in the study. The live birth rate following AIH was 5.61% (25/446), which was significantly lower than that following IVF (25.13%; 140/557). In the subgroup analysis, the cumulative live birth rates in AIH group were significantly lower than those in the IVF groups (in the 10–12 IU/L bFSH subgroup, 13.74% vs. 41.13% (P<0.05) for patients aged ≤35 years, and 4.82% vs. 19.77% (P<0.05) for patients aged >35 years; in the >12 IU/L bFSH subgroup, 9.52% vs. 29.91% (P<0.05) for patients aged ≤35 years, and 5.71% vs. 20.55% (P<0.05) for patients aged >35 years). Longitudinal analysis showed that majority of live births, in AIH or IVF groups, were achieved in the first two cycles.
Conclusions: In subfertile women with DOR, live birth rates following AIH were significantly lower than IVF, especially for the aged women. Considering the low efficacy of AIH and that majority of live births were achieved in the first two cycles, we suggest no more than two AIH treatment attempts for the aged women with DOR.
doi: https://doi.org/10.12669/pjms.39.2.6226
How to cite this: Wang ZY, Huang SX, Yang JD, Li DP, Xu YW. Subfertile Chinese patients with diminished ovarian reserve: An analysis of pregnancy outcomes of ART cycles. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.6226
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Defining the role of the antineoplastic drug bleomycin based on toxicogenomic-DNA damage inducing (TGx-DDI) genomic biomarkers data: A meta-analysis using next-generation knowledge discovery method
Authors: Pushparaj Peter Natesan , Rasool Mahmood , Naseer Muhammad Imran , Gauthaman Kalamegam 
Published: January 2023

Objectives: Accurately identifying the cellular, biomolecular, and toxicological functions of anticancer drugs help to decipher the potential risk of genotoxicity and other side effects. Here, we examined bleomycin for cellular, molecular and toxicological mechanisms using next-generation knowledge discovery (NGKD) tools.
Methods: This study was conducted at the Faculty of Applied Medical Sciences, King Abdulaziz University (KAU), Jeddah, Saudi Arabia in October 2022. We first analyzed the raw Toxicogenomic and DNA damage-inducing (TGx-DDI) gene expression data from Gene Expression Omnibus (GEO) (GSE196373) of TK6 cells treated with 10 µM bleomycin and TK6 cells treated with DMSO for four hours using the GEO2R tool based on the Linear Models for Microarray Analysis (limma) R packages to derive the differentially expressed genes (DEGs). Then, iPathwayGuide was used to determine differentially regulated signaling pathways, biological processes, cellular, molecular functions and upstream regulators (genes and miRNAs).
Results: Bleomycin differently regulates the p53 pathway, transcriptional dysregulation in cancer, FOXO pathway, viral carcinogenesis, and cancer pathways. The biological processes such as p53 class mediator signaling, intrinsic apoptotic signaling, DNA damage response, and DNA damage-induced intrinsic apoptotic signaling and molecular functions like ubiquitin protein transferase and p53 binding were differentially regulated by bleomycin. iPathwayGuide analysis showed that the p53 and its regulatory gene and microRNA networks induced by bleomycin.
Conclusion: Analysis of TGx-DDI data of bleomycin using NGKD tools provided information about toxicogenomics and other mechanisms. Integration of all “omics” based approaches is crucial for the development of translatable biomarkers for evaluating anticancer drugs for safety and efficacy.
doi: https://doi.org/10.12669/pjms.39.2.7321
How to cite this: Pushparaj PN, Rasool M, Naseer MI, Gauthaman K. Defining the role of the antineoplastic drug bleomycin based on toxicogenomic-DNA damage inducing (TGx-DDI) genomic biomarkers data: A meta-analysis using next-generation knowledge discovery method. Pak J Med Sci. 2023;39(2):---------. doi: https://doi.org/10.12669/pjms.39.2.7321
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A scoping and web-based review of current practices and lessons learnt in development and sustainability of global health emergency medicine fellowships
Authors: Khan Haniya , McKnight Alex , Gamble Kathleen , Puchalski Ritchie Lisa M 
Published: January 2023

Background: Despite significant interest in advanced global health training among Canadian emergency medicine trainees, only one global health emergency medicine (GHEM) fellowship existed in Canada at the time of this review. We conducted a scoping and web-based review to summarize the components of, and lessons learnt through development and implementation of global health emergency medicine fellowship programs to date, to inform program development. Methods: We conducted a scoping and web-based review by systematically searching electronic databases from inception to 2021 for articles and websites (2022) describing global health emergency medicine training programs based in high income countries. Results: From 2957 articles and 62 websites identified, eight articles and 43 websites were included in the review. Fellowships are generally structured as follows: 1–2 years duration curriculum including clinical skills, and course and field work focused on education, research or administration, funded by fellows’ clinical hours. Details on trainees’ experiences, international work, and program outcomes were lacking. Conclusions: This review highlights the need for information on lessons learnt through development and implementation of GHEM fellowship programs, and experiences and outcomes of trainees to date, to inform program improvements to optimize the benefits of GHEM fellowship training. Registration: Open science framework; https://doi.org/10.17605/OSF.IO/UAH35 February 19th, 2018.
Underdogs and One-Hit Wonders: When Is Overcoming Adversity Impressive?
Authors: Denrell Jerker , Liu Chengwei , Maslach David 
Published: January 2023

Success tends to increase and failure tends to decrease the chances of future success. We show that this impact of past outcomes can change how diagnostic success or failure are regarding the competence of an individual or a firm. Succeeding under adverse circumstances is especially impressive when initial failure reduces the chances of success more for low-quality agents than for high-quality agents. Succeeding after initial failure (being a “successful underdog”) can also indicate higher expected quality than succeeding twice if initial success increases the chances of success of all agents to a high level. In different circumstances, the outcome after success can be especially informative about quality, implying that failing after an initial success (a “one-hit wonder”) indicates lower quality than failing twice does. We find effects consistent with our model in data on Canadian professional hockey players and on data from the Music Laboratory experiment: Initial failure combined with eventual success is associated with high quality. The results help to clarify when failure should be attributed to the person in charge or to the situation, when underdogs and individuals who overcome adversity are especially impressive and when a naïve “more is better” heuristic for evaluating performance can be misleading. This paper was accepted by Isabel Fernandez-Mateo, organizations. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2022.4630 .
New Algorithms for Hierarchical Optimization in Kidney Exchange Programs
Authors: Delorme Maxence , García Sergio , Gondzio Jacek , Kalcsics Jörg , Manlove David , Pettersson William 
Published: January 2023

New Exact Approaches Tailored for Kidney Exchange Programs with Hierarchical Objectives Kidney exchange programs increase the rate of living donor kidney transplantation. Whereas effective integer programming models aimed at maximizing the total number of transplants have been proposed in the literature, these cannot always be extended to handle a hierarchy of objectives, which is often a requirement in practice. In “New Algorithms for Hierarchical Optimization in Kidney Exchange Programs,” Delorme, García, Gondzio, Kalcsics, Manlove, and Pettersson introduce a new integer programming framework to solve large-size instances of kidney exchange programs. The authors use an ad hoc preprocessing and a reduced-cost variable fixing algorithm to dramatically decrease the size of the models, and they devise a diving algorithm that exploits the hierarchical structure of the problem to significantly reduce the number of integer programs that need to be solved. They also show that it is possible to transition between models as different layers are traversed in the hierarchy, allowing each layer to be solved with the most effective model. Experiments on three different European kidney exchange programs show that running times can be reduced by up to three orders of magnitude.
Facilitators and barriers regarding the implementation and interprofessional collaboration of a first contact physiotherapy service in primary care in Wales: a qualitative study
Authors: Lewis Matthew William , Gill Paul 
Published: January 2023

Background/Aims Future primary care services in Wales are likely to face higher demand for musculoskeletal ailments because of an ageing population and difficulties retaining and recruiting general practitioners. First contact physiotherapists provide specialist musculoskeletal management within primary care and offer a solution to this issue; however, no studies have yet explored first contact physiotherapist services in Wales. Consequently, little is known about the experience of working as a first contact physiotherapist in Wales. The aim of this study was to explore the experiences of first contact physiotherapists in primary care in south east Wales regarding the implementation, interprofessional collaboration and the facilitators and barriers to providing the service. Methods A qualitative, Heideggerian hermeneutical phenomenological study was performed. A purposive sample of eleven physiotherapists were recruited for the study from an NHS health board in south east Wales, comprising three different first contact physiotherapist models. Data were collected through individual semi-structured interviews. Data analysis was conducted via a three-step format. Results Participants viewed the first contact physiotherapist role as positive as it represented role and career advancement. Adequate training and mentorship were not provided to support the role. Participants perceived that patients and the wider multidisciplinary team did not fully understand the role of the first contact physiotherapist. Inappropriate use of services was common, with first contact physiotherapists often acting as the second contact practitioner, leading to duplication of effort and the development of unnecessary waiting lists. The degree of interprofessional collaboration appeared to influence the clarity of the role of the first contact physiotherapist, with a reduced clarity of role in models where first contact physiotherapists were not often present. Burnout was perceived as a risk for participants with low levels of experience in advanced practice and was dependent on the model worked in. Participants perceived a lack of specific aims for the first contact physiotherapy service and ambiguity over who was responsible for service leadership, leading to inappropriate use of services. Conclusions Clear operational leadership and strategies to increase interprofessional collaboration are required to increase the clarity about the roled of the first contact physiotherapist and ensure service efficacy. There is a need in Wales for a professional development, mentorship and governance framework to ensure sustainability and efficacy of first contact physiotherapy services.
The effect of parent-based occupational therapy on parents of children with cerebral palsy: a randomised controlled trial
Authors: Akyurek Gokcen , Gurlek Sedanur , Ozturk Leyla Kaya , Bumin Gonca 
Published: January 2023

Background/Aims Parents of children with cerebral palsy face higher levels of stress, anxiety and depression, sadness, exhaustion and burnout. Parent-based therapies have been found to increase parents' satisfaction with therapy, parent–child interactions and reduced parental stress. This study examined the effects of parent-based occupational therapy on stress levels, coping skills, and emotional skills and competencies of parents of children with cerebral palsy. Methods A total of 15 children and their parents who were admitted to the paediatric rehabilitation unit for occupational therapy were divided into two groups (control group: n=7, study group: n=8) using the coin toss randomisation method. The control group received standard occupational therapy, while the study group received parent-based occupational therapy for 45 minutes a session, twice a week, until 10 sessions had been completed. Participants were evaluated before and after the intervention. Results The study group showed a decrease in stress levels (P=0.034) and increases in coping skills (P=0.016), and emotional skills and competencies (P=0.036). In addition, only an improvement in parents' stress levels (P=0.046) was observed in the control group. Conclusions The parent-based occupational therapy programme was more effective regarding stress levels, coping skills, emotional skills and competencies of the families of children with cerebral palsy compared to classical occupational therapy. This study is important in terms of demonstrating the benefits of parent-based occupational therapy for parents of children with cerebral palsy.
Fast shaping control of x ray beams using a closed-loop adaptive bimorph deformable mirror
Authors: Alcock Simon , Nistea Ioana , Badami Vivek , Signorato Riccardo , fusco Matteo , Hu Lingfei , Wang Hongchang , Sawhney Kawal 
Published: January 2023

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<p>High-speed adaptive correction of optics, based on real-time metrology feedback, has benefitted numerous scientific communities for several decades. However, it remains a major technological challenge to extend this concept into the hard X-ray regime due to the necessity for active mirrors with single-digit nanometer height errors relative to a range of aspheric forms. We have developed the first high-resolution, real-time, closed-loop “adaptive” optical system for synchrotron and X-ray free electron laser (XFEL) applications. After calibration of the wavefront using X-ray speckle scanning, the wavefront diagnostic was removed from the X-ray beam path. Non-invasive control of the size and shape of the reflected X-ray beam was then demonstrated by driving a piezoelectric deformable bimorph mirror at ~ 1 Hz. Continuous feedback was provided by a 20 kHz direct measurement of the optical surface with picometer sensitivity using an array of interferometric sensors. This enabled a non-specialist operator to reproduce a series of pre-defined X-ray wavefronts, including focused or non-Gaussian profiles, such as flat-top intensity or multiple split-peaks with controllable separation and relative amplitude. Such changes can be applied in any order and in rapid succession without the need for invasive wavefront diagnostic sensors which block the X-ray beam for scientific usage. These innovations have the potential to profoundly change how X-ray focusing elements are utilized at synchrotron radiation and XFEL sources and provide unprecedented dynamic control of photon beams to aid scientific discoveries in a wide range of disciplines.</p>
Time trends in body height according to educational level. A descriptive study from the Tromsø Study 1979–2016
Authors: Arntsen Sondre Haakonson , Borch Kristin Benjaminsen , Wilsgaard Tom , Njølstad Inger , Hansen Anne Helen 
Published: January 2023

Objectives
The objective of our study was to describe time trends in body height according to attained educational level in women and men in Norway.

Methods
We used previously collected data from six repeated cross-sectional studies in the population based Tromsø Study 1979–2016. Measured body height in cm and self-reported educational level were the primary outcome measures. We included 31 466 women and men aged 30–49 years, born between 1930 and 1977. Participants were stratified by 10-year birth cohorts and allocated into four groups based on attained levels of education. Descriptive statistics was used to estimate mean body height and calculate height differences between groups with different educational levels.

Results
Mean body height increased by 3.4 cm (95% confidence interval (CI) 3.0, 3.8) in women (162.5–165.9 cm) and men (175.9–179.3 cm) between 1930 and 1977. The height difference between groups with primary education compared to long tertiary education was 5.1 cm (95% CI 3.7, 6.5) in women (161.6–166.7 cm) and 4.3 cm (95% CI 3.3, 5.3) in men (175.0–179.3 cm) born in 1930–39. The height differences between these educational groups were reduced to 3.0 cm (95% CI 1.9, 4.1) in women (163.6–166.6 cm) and 2.0 cm (95% CI 0.9, 3.1) in men (178.3–180.3 cm) born in 1970–77.

Conclusions
Body height increased in women and men. Women and men with long tertiary education had the highest mean body height, which remained stable across all birth cohorts. Women and men in the three other groups had a gradual increase in height by birth cohort, reducing overall height differences between educational groups in our study population.