bluuebunny/crossref_metadata_2025_split huggingface dataset:
UNIVERSIDADE WYKA KWARA: UMA UNIVERSIDADE CULTURALMENTE ECOLÓGICA E AMBIENTALMENTE SUSTENTÁVEL
Authors: Batista Heloan Patrick da Silva , Leonido Levi , Morgado Elsa Maria Gabriel 
Published: January 2023

O plano da construção da Universidade Wyka Kwara na Ilha de Cotijuba, em Belém do Pará, busca formas de construção sustentável com vista a reduzir os impactos ambientais causados pelo Homem. Foi feito um levantamento prévio das conceções na questão do voluntariado, no qual foi disponibilizado online um questionário, nos grupos de acolhimento da rede social do WhatsApp, contendo 13 perguntas, sendo 11 fechado e 2 duas abertas. O planeamento de construção é divido por 3 fases, o projeto caracteriza-se de longa duração (de 12 a 14 anos). O presente trabalho procura fazer uma reflexão acerca da pegada ecológica da construção civil e dos danos e consequências causadas por essas construções, e apresentar o projeto de construção de uma universidade indígena.
A UTILIZAÇÃO DA MÚSICA NO CINEMA TURCO: sinemacilar período
Authors: Karaaslan Elanur , Leonido Levi 
Published: January 2023

O cinema apareceu em 1895. Ainda hoje, é uma das artes mais recentes que estão a ser discutidas. Após a invenção do cinema, os filmes foram rodados durante 30-35 anos sem qualquer diálogo. Mesmo durante este período, os filmes eram acompanhados de música, externamente, com um violino ou orquestra. A razão mais importante para isto é a importância da transferência de emoções na narração de histórias. A música, por outro lado, é a forma mais fácil de transmitir os sentidos ao espírito humano. Há uma palavra estereotipada e universal. "A música é o alimento da alma". A relação entre cinema e música é uma relação auto-existente e obrigatória. Neste estudo, no contexto da relação entre música e cinema e da necessidade desta relação, pretende-se fazer determinações sobre como a utilização da música na era Sinemacılar do cinema turco, o valor dado à banda sonora e à indústria turca da banda sonora. O escritor de cinema Nijat Özön dividiu o cinema turco em determinados períodos. Um destes períodos é o período de Sinemacılar que abrange o período que vai de 1952 até 1960. A razão da escolha deste período; o cinema turco fez um esforço para criar uma identidade neste período. Alguns escritores de cinema aceitam o período do Sinemacılar como o início do cinema turco. Porque, segundo eles, os principais filmes do cinema turco começaram a ser produzidos nesse período. No estudo, o método de análise de conteúdo será utilizado através da digitalização da literatura. Contribuir para a literatura é outro objetivo.
Pelatihan Pengelolaan Website untuk Pengurus PC dan Pengurus PAC Muslimat NU Se-Kebumen
Authors: Waluyo Ari , Wakhid Yuliyanto  , Asni Tafrikhatin  , Wahyu Nur Hidayat  , Abdurahman Mahmud  , Yuni Pancawati  , Alfi Rohmatul Fauziyah  
Published: January 2023

Abstrak: Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan sumber daya manusia para pengurus PC dan Pengurus PAC Muslimat NU Kebumen, khususnya pada pengelolaan website. Kegiatan ini bekerjasama antara Politeknik Piksi Ganesha Indonesia dengan Lakpesdam PCNU Kebumen dengan peserta seluruh pengurus PAC Muslimat Nu se-Kab. Kebumen. Kegiatan tersebut dilaksanakan dengan beberapa tahapan mulai dari pembentukan tim, analisa, pelaksanaan dan mengevaluasi. Dalam pelaksanaan kegiatan ini berjalan dengan baik, para peserta juga sangat antusias dalam mengikuti peltihan pengelolaan website ini. Dari hasil evaluasi juga menujukan adanya peningkatan peserta dalam hal pengelolaan website
Pelatihan Update Teknologi Otomotif Jurusan Teknik Kendaraan Ringan SMK Insan Cendekia Yogyakarta
Authors: Bahtiar Bahtiar Wilantara , Lilik Kurniawan  , Hanif Fitriyanto  , Muhammad Fahbil Tegar  , Arif Wibowo  
Published: January 2023

Peningkatan kualitas lulusan SMK dapat dilakukan dengan melakukan upskilling dan reskilling siswa kejuruan. Kegiatan pelatihan dilakukan untuk meningkatkan kualitas lulusan SMK Kejuruan melaui update teknologi otomotif materi EFI dan engine tune up. Metode yang digunakan untuk menyampaikan materi adalah metode problem based learning dan demonstrasi. Setelah materi disampaikan selanjutnya dibandingkan nilai rata-rata pre-test dan post-test siswa. Hasil pelatihan adalah kegiatan pengabdian update teknologi otomotif di SMK Insan Cendekia Yogyakarta berhasil dilakukan ditinjau dari nilai rata-rata siswa yang ≤75 adalah 98%.
ANALISIS PAJAK PENGHASILAN BADAN TERUTANG YANG DIUKUR BERDASARKAN PENJUALAN BERSIH DAN BIAYA OPERASIONAL
Authors: Hasan Julian Muhammad , Septiningrum Liana Dwi 
Published: January 2023

This research aims to prove empirically the effect of net sales and operating expenses on Outstanding Corporate Income Tax. The independent variables used in the study were net sales and operating expenses while the dependent variables were owed Corporate Income Tax. This research was conducted in food and beverage sector companies listed on the Indonesia Stock Exchange (IDX) in 2016 - 2020. The research method used is descriptive quantitative. The type of data used is secondary data in the form of financial statements published by food and beverage companies listed on the Indonesia Stock Exchange (IDX) in 2016 - 2020. Samples are collected using the purposive sampling method. The number of companies used as research samples as many as 9 companies with a research period of 5 (five)years, so that as many as 45 samples were obtained. Processing data by using Eviews version 10 for windows by collecting related data then calculating net sales, operating expenses and Income Tax of owed Entities and analyzing descriptivek statisti,panel data model test, panel data regression model, classical assumption test,panel data regression analysis test, T statistical test, F statistics test, and coefficient of determination (R2). The results of the F test of net sales and operating expenses simultaneously affect pajak penghasilan badan terutang. The results of the T test variable net sales and operating expenses partially affect the Outstanding Corporate Income Tax.
Analysis of the Value Chain and Supply Chain of the Pharmaceutical industry for Human use in Spain
Authors: Amaro-Martínez Francisco , De Castro Vila Rodolfo 
Published: January 2023

El presente artículo es sobre un trabajo de investigación de la Cadena de suministro del sector farmacéutico para uso humano en España. En concreto se centra en la distribución de medicamentos de uso humano desde los Laboratorios Farmacéuticos a los Mayoristas y a las Oficinas de Farmacia (OOFF) en España, en base a los diferentes tipos de medicamentos. En la investigación bibliográfica realizada se ha visto por un lado la importancia de la integración colaborativa para conseguir la excelencia operativa en las Cadenas de Suministro de cualquier sector de actividad y, por otro lado, que no existe en la bibliografía ningún estudio que profundice en este sentido el sector farmacéutico en general, y en España en particular. En este artículo se presentan los resultados de la investigación fruto de la revisión bibliográfica inicial, y del trabajo de campo que se realizó posteriormente a los Laboratorios farmacéuticos. Finalmente, con esta investigación se aspira a contribuir a mejorar tanto el servicio prestado a los pacientes, como la rentabilidad de todos los agentes de la Cadena de suministro de este sector (Laboratorios Farmacéuticos, Mayoristas, y OOFF). A partir de estos resultados se prevé también llevar a cabo futuras investigaciones con los siguientes eslabones de la cadena de suministro de este sector.
La CTS en la enseñanza de la ciencia en instituciones de educación media de Latinoamérica, 2018-2022
Authors: Naranjo Mora Maira Juana , Veloz Ronquillo Víctor Xavier , De La Cruz Lozado Juan 
Published: January 2023

El estudio de revisión tiene por objetivo evaluar de manera sistemática los documentos con alto grado de relevancia en artículos científicos sobre el impacto en el sistema educativo de la CTS en la enseñanza de la ciencia en instituciones de educación media en Latinoamérica. Las bases de datos consultadas son: Scopus, DIALNET, ProQuest, Scholar y Scielo. También se realizó la revisión de referencias bibliográficas tanto de estudios primarios como secundarios. Dentro del estudio se consideró el período de tiempo 2018 - 2022. Se tomaron artículos que permitieron verificar el impacto de la CTS en para la enseñanza de la ciencia en instituciones académicas. Se excluyeron los estudios que abarcaron la CTS a nivel superior y los estudios que no pertenecían a Latinoamérica.
Los resultados más relevantes muestran que la CTS en la enseñanza de la ciencia proporciona un cambio de formación de actitud, de responsabilidad y de valores, haciendo posible la democratización de ciudadanos, con toma de decisiones relacionadas con problemáticas sociales concernientes a la ciencia y tecnología. Este estudio de carácter bibliográfico ha permitido precisar la CTS como una innovación educativa destinada a promover la alfabetización tecnológica y científica, contribuyendo a la formación de actitudes responsables.
Inteligencia emocional y el aprendizaje significativo en los estudiantes de la facultad de educación de la universidad nacional de Cajamarca
Authors: Llanos Bardales Jaime , Machuca Cabrera Yanet Jackelin , Cáceres Mendoza Mariano Guzmán 
Published: January 2023

El propósito de la investigación busca determinar si la inteligencia emocional se relaciona con el aprendizaje significativo en los estudiantes de la facultad de educación de la Universidad Nacional de Cajamarca, primeramente, se identifica el nivel de inteligencia emocional y aprendizaje significativo en los estudiantes, la metodología fue básica, diseño no experimental descriptivo correlacional, usando un muestro probabilístico estratificado se extrajeron 284 estudiantes de una población de 1079 estudiantes. Se aplicó un cuestionario TMMS-24 para inteligencia emocional y otro cuestionario para el aprendizaje significativo ambos confiables (0.916 y 0.942). Del tratamiento de datos exhibimos que el 68% de los estudiantes (194) tienen una inteligencia emocional normal, presentan una adecuada claridad emocional, pero deben mejora su atención y reparación emocional. En tanto, el 55% de los estudiantes (155) manifiestan un aprendizaje significativo normal, evidenciándose sus actitudes y percepciones, adquisición e integración del conocimiento, extensión y refinamiento del conocimiento y uso significativo del conocimiento normal, evidenciando hábitos mentales para pensar críticamente, creativamente y regular su comportamiento con normalidad. Finalmente, un Rho = 0.522, indica que existe una correlación positiva moderada, entre la inteligencia emocional y el aprendizaje significativo en los estudiantes de educación.
Akselerasi Pemanfaatan Aplikasi Pengelolaan Keuangan Digital Sektor UKM di Jawa Timur dan Nusa Tenggara Barat
Authors: Indrasari Meithiana , Pamuji Eko , Prasnowo M Adhi , Aziz Muhajir Sulthonul , Nurcahyo Moch. Subechi 
Published: January 2023

Percepatan transformasi digital pada sektor Usaha Kecil Menengah (UKM) menjadi target dan rencana besar pemerintah hingga tahun 2024. Dalam pertumbuhannya, UKM harus menjadi salah satu roda penggerak utama dalam pembangunan dan pengembangan ekonomi. UKM harus melakukan pengelolaan keuangan. Di era teknologi yang serba canggih semua hal dilakukan dengan cara manual, dapat terselesaikan dengan cara digital, contohnya pencatatan serta pembukuan dengan menggunakan aplikasi pencatatan pembukuan. Sehingga perlu dilaksanakan program pelatihan Digital Enterpreunership Academy (DEA) Pengelolaan Keuangan Digital. Metode palksanaan dengan dengan memberikan pelatihan dengan kurikulum kelas offline 2 hari 13 Jam Pertemuan dengan hasil memberikan wawasan dan pemahaman baru bagi para peserta untuk mampu bersaing secara global di sektor usaha masing-masing. Hal tersebut dijelaskan bahwa 95% peserta menilai bahwa materi relevan dengan permasalahan-permasalahan yang dihadapi oleh peserta juga secara kemanfaatan pelatihan dapat dinilai memiliki tingkat keberlanjutan yang layak untuk terus dilaksanakan.
De partages d’émois professionnels au processus collectif d’écriture : une démarche de recherche
Authors: Durual Arlette , Joly Brigitte , Mony Myriam , Morel-Lab Anne 
Published: January 2023

Partant d’écrits individuels, une démarche de dialogue, d’analyse et d’écriture collective s’expérimente sous la thématique du sensible en écriture de recherche. Le texte proposé tourbillonne autour de ces deux axes : écriture collective et le sensible comme fondateur d’une écriture de recherche. Il en résulte un paysage au seuil d’une recherche éventuelle.
Travel Management Planning for Wildlife with a Case Study on the Mojave Desert Tortoise
Authors: Averill-Murray Roy C. , Allison Linda J. 
Published: January 2023

Abstract
Roads are important drivers of habitat loss, degradation, and fragmentation that affect global biodiversity. Detrimental effects of roads include direct mortality of individual animals, spread of habitat-altering invasive plants, and loss of demographic and genetic connectivity of wildlife populations. Various measures address the negative effects of roads on wildlife. However, most strategies for minimizing or mitigating the effects of roads are focused on the actual roads themselves rather than on the collective travel network across landscapes. We summarized a growing body of literature that has documented the effects of road density on wildlife populations and the benefits associated with lower densities. This literature supports the application of limits on road density as a viable tool for managing cumulative effects. Based on these examples, we recommend road densities, including all linear features used for travel, of less than 0.6 km/km2 as a general target for travel management in areas where wildlife conservation is a priority. Lower densities may be necessary in particularly sensitive areas, whereas higher densities may be appropriate in areas less important to landscape-level conservation and wildlife connectivity. Public policy and funding also are needed to address challenges of enforcing off-highway vehicle regulations. In applying this general overview to a case study of the Mojave desert tortoise Gopherus agassizii, we found that all management plans across the species' range lack considerations of road density and that tortoise populations declined within all conservation areas with road densities of more than 0.75 km/km2. From this, we provide several travel management recommendations specific to Mojave desert tortoise conservation beginning with identifying the entire travel network within management areas. Specific actions for managing or setting limits for road density depend on the site-specific biological or management context, for instance relative to habitat quality or proximity to designated tortoise conservation areas. In addition, increasing law enforcement and public outreach will improve enforcement and compliance of travel regulations, and installing tortoise-exclusion fencing along highways will reduce road kills and allow tortoise populations to reoccupy depleted areas adjacent to highways. Implementation of these recommendations would improve the prospects of reversing desert tortoise population declines.
Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.
Authors: Van Zee K J , Moldawer L L , Oldenburg H S , Thompson W A , Stackpole S A , Montegut W J , Rogy M A , Meschter C , Gallati H , Schiller C D , Richter W F , Loetscher H , Ashkenazi A , Chamow S M , Wurm F , Calvano S E , Lowry S F , Lesslauer W 
Published: January 2023

Abstract
Fusion proteins of the human 55-kDa TNF receptor extracellular domain with hinge and C2/C3 constant domains of human IgG1 or IgG3 heavy chains were tested in a primate sepsis model. Twenty-four baboons received 4.6, or 0.2 mg/kg of TNFR5-G1,3, or placebo, before the administration of a lethal dose of live Escherichia coli. Treatment with TNFR5-G1,3 decreased 5-day mortality from 88% in the placebo group to 12% in the TNFR5-G1,3-treated animals (p &lt; 0.01 by Fisher's exact test). Treatments with TNR5-G1 and TNFR5-G3 in doses from 0.2 to 4.6 mg/kg were efficacious. Free plasma TNF was neutralized by all treatments, but inactive TNF/TNFR5-G1,3 complexes remained in circulation for prolonged periods. TNFR5-1,3 treatments attenuated the hemodynamic disturbances, reduced fluid requirements, and decreased the systemic IL-1 beta, IL-6, and IL-8 responses. In addition, TNFR5-G1,3 treatment shortened the granulocytopenia and reduced the loss of cellular TNF receptors from granulocytes. The decrease in fibrinogen concentrations and increase in prothrombin and partial thromboplastin times were significantly attenuated by TNFR5-G1,3 treatment. TNFR5-G1,3 treatment markedly attenuated the rise in plasma lactate concentration. Histologic studies of TNFR5-G1,3 revealed dose-dependent protection against tissue injury by Escherichia coli administration.
The split-virus influenza vaccine activates Fcγ receptors instead of Toll-like receptors (VAC2P.930)
Authors: O'Gorman William , Huang Huang , Wei Yu-Ling , Davis Kara , Leipold Michael , Bendall Sean , Kidd Brian , Dekker Cornelia , Maecker Holden , Chien Yueh-hsiu , Davis Mark 
Published: January 2023

Abstract
Seasonal influenza vaccination is the most common medical procedure targeting the immune system and yet the extent to which influenza vaccination activates innate immunity in humans is not fully understood. Currently, the most prevalent formulations of the vaccine consist of degraded or “split” viral particles often prepared without any adjuvants. We sought to determine whether the unadjuvanted split influenza vaccine activates innate immune receptors—specifically Toll-like receptors. A mass-cytometry (CyTOF) based proteomic profiling platform was developed and used to compare signaling pathway activation and cytokine production between the split influenza vaccine and a prototypical TLR response in human whole-blood (ex vivo). This analysis revealed that the split vaccine rapidly and potently activates multiple immune cell types but yields a proteomic signature distinct from TLR activation. Importantly, vaccine induced activity was dependent upon the presence of human sera indicating that a serum factor was necessary for vaccine-dependent immune activation. We found this serum factor to be human antibodies specific for influenza proteins and therefore immediate immune activation by the split vaccine is immune-complex dependent. These studies demonstrate that influenza vaccine splitting inactivates any microbial adjuvants endogenous to influenza but potentially elicits a potent immune modulator by facilitating the rapid formation of immune complexes.
The Inhibition of Bruton Tyrosine Kinase Alleviates Acute Liver Failure via Downregulation of NLRP3 Inflammasome
Authors: Ye Bingjue , Chen Shiwei , Guo Huiting , Zheng Weiyang , Lou Guohua , Liang Xue , Liu Yanning , Zhou Cheng , Zheng Min 
Published: January 2023

Abstract
There is no effective treatment for acute liver failure (ALF) except for an artificial liver support system (ALSS) and liver transplant. Bruton tyrosine kinase (Btk) plays important immunoregulatory roles in the inflammatory diseases, but its possible function in ALF remains to be characterized. In this study, we detected the phosphorylation level of Btk in ALF mouse liver and analyzed the protective effects of Btk inhibitor on survival rate and liver damage in ALF mouse models. We measured the expression levels of various inflammatory cytokines in the ALF mouse liver and primary human monocytes. In addition, we examined the expression of the NLRP3 inflammasome in mouse models with or without Btk inhibition. Clinically, we observed the dynamic changes of Btk expression in PBMCs of ALSS-treated patients. Our results showed that Btk was upregulated significantly in the experimental ALF mouse models and that Btk inhibition alleviated liver injury and reduced the mortality in these models. The protective effect of Btk inhibitors on ALF mice partially depended on the suppression of NLRP3 inflammasome signaling. Clinical investigations revealed that the dynamic changes of Btk expression in PBMCs could predict the effect of ALSS treatment. Our work shows that Btk inhibition is an effective therapeutic strategy for ALF. Moreover, Btk is a useful indicator to predict the therapeutic effect of ALSS on liver failure, which might have great value in clinical practice.
Sirt1 is responsible for antigen presentation in B cells through induction of CIITA expression and CIITA deacetylation
Authors: Park Seok-Rae , Han Younghwan , Shin Jongdae , Kang Jaeku 
Published: January 2023

Abstract
The NAD+-dependent deacetylase Sirt1 is known to modulate metabolism, inflammation, and aging. It has been reported that Sirt1 regulates differentiation and function of innate immune cells and T cells. However, the role of Sirt1 in B cell functions has not been well studied. The present study aimed to determine the role of Sirt1 in antigen presentation function of B cells. First, we investigated the effects of Sirt1 activator/inhibitor and Sirt1 deficiency on expression of major components (Ii, DM, DO, and MHC II) of the MHC II antigen presentation pathway in B cells, and we determined whether antigen presentation function of B cells is dependent on Sirt1 using an experiment regarding CD4+ OT-II T cell responses to OVA-pulsed Sirt1-deficient B cells or OVA-pulsed Sirt1 activator/inhibitor-stimulated B cells in vitro co-culture. Expression of all the components in B cells and CD4+ OT-II T differentiation to CD4+ TNF-α+ (Th1), CD4+ IL-17+ (Th17), and CD4+ IL-21+ (Tfh) cells were diminished in the case of Sirt1 inhibitor-treated B cells or Sirt1-deficient B cells, while Sirt1 activator increased the expression and the differentiation. Next, we found that Sirt1 deacetylates CIITA, a key transcription factor of transcription of the major components in the MHC II antigen presentation pathway, in B cells. In addition, we revealed that Sirt1 is required for CIITA expression. Taken together, we conclude that Sirt1 is essential for antigen presentation by B cells, and this might be caused by induction of CIITA expression and deacetylation of CIITA.
Supported by grants from NRF (2016R1D1A1B04935588, 2017R1A6A1A03015713)