bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes
Authors: Matsathit Udomlak , Komolkriengkrai Manaras , Khimmaktong Wipapan 
Published: January 2025

BACKGROUND
Small blood vessels in the eyes are more susceptible to injury, which can lead to complications. However, since diabetic retinopathy is often a serious clinical condition, most of this study focuses on the vascular system of the choroid. As part of this study, we looked at how gymnemic acid (from Gymnema sylvestre ) and glabridin (from Glycyrrhiza glabra , or licorice) might help diabetic rats’ choroid structural change and blood vessels.
AIM
To explore the effects of glabridin and gymnemic acid on the structural changes of the choroidal layer and choriocapillaris as well as the expression of vascular endothelial growth factor (VEGF) and cluster of differentiation (CD) 31 in diabetic rat’s eye.
METHODS
The male Wistar rats were separated into five groups: The control group (control), the diabetic group (DM), the diabetic rats treated with glabridin 40 mg/kg body weight (DM + GB), the diabetic rats treated with gymnemic acid 400 mg/kg body weight (DM + GM), and the diabetic rats treated with glyburide 4 mg/kg body weight (DM + GR).
RESULTS
There was an increase in the thickness of both the choroid layer and the wall of the arteries in the DM. A decrease in vascularity and choroidal impairment was found in DM rats. After eight weeks of experimentation, the choroidal thickness increased, and the walls of choroid arteries. The choroidal thickness in the DM + GB was 15.69 ± 1.54 μm, DM + GM was 14.84 ± 1.31, and DM + GR groups was 16.45 ± 1.15 when compared with DM group (27.22 ± 2.05), the walls thickness of choroid arteries in the DM + GB was 10.23 ± 1.11, DM + GM was 10.41 ± 1.44, and DM + GR was 9.80 ± 1.78 when compared with DM group (16.35 ± 5.01), The expression of VEGF and CD31 was lower compared to the DM group.
CONCLUSION
In diabetic choroidopathy, hyperglycemia and inflammation cause damage to the neurovascular unit and blood-retinal barrier. Anti-VEGF treatments can slow or reverse the progression of the disease. According to current research findings, glabridin and gymnemic acid can reduce damage to the choroid, which is a factor that can sometimes result in vision loss.
Feeding tube self-management experience of patients at home after discharge following esophageal cancer surgery
Authors: Miao Guo-Li , You Qing-Jun , Feng Xiao-Yan , Chu Jiang-Hui , Li Jin-You , Cai Ping 
Published: January 2025

BACKGROUND
Esophageal cancer (EC) is an aggressive malignancy with low survival (10%-30%). Nutritional problems are present throughout the perioperative period and are key to prognosis. Home enteral nutrition appears to improve the nutritional status of patients with EC. Few studies have addressed the experience of patients administering their own nutritional fluids and managing their own feeding tubes at home. The aim of this study was to explore the real-life experience of self-management of feeding tubes in patients at home after EC surgery in the first 3 months after discharge following surgery.
AIM
To explore feeding tube self-management experience of patients at home 3 months after discharge following EC surgery.
METHODS
Face-to-face semi-structured interviews were conducted with 18 patients using a feeding tube at home after EC surgery. Thematic analysis of the recordings identified themes related to feeding tube self-management.
RESULTS
Patients expressed similar feelings about their tube management experiences concerning three contextualized themes: Self-management dilemmas, distressing experiences, and self-management facilitators.
CONCLUSION
There are many dilemmas and problems in self-managing feeding tubes in postoperative homebound patients with EC. Clinical staff should provide guidance to promote a positive change in self-management behavior.
Preliminary study on the clinical value of endoscopic stricturotomy in the treatment of stricturing Crohn's disease
Authors: Cui Lu , Su Min , Ding Yan-Bo , Wang Mei , Sun Ke-Wen 
Published: January 2025

BACKGROUND
Crohn's disease (CD) frequently leads to intestinal strictures, which pose significant challenges due to their complexity and limited treatment options. While medications can address inflammatory strictures, they are largely ineffective for fibrotic and mixed strictures, often necessitating surgical intervention. However, surgery carries considerable risks, including bleeding, infection, anastomotic leaks, and postoperative restricture formation. Endoscopic treatment, particularly endoscopic stricturotomy, offers a minimally invasive alternative that bridges the gap between medication and surgery.
AIM
To investigate the safety and efficacy of stricturotomy under single-balloon enteroscopy in stricturing CD.
METHODS
Patients diagnosed with stricturing CD at The First People's Hospital of Changzhou from June 2020 to April 2024 were enrolled and underwent endoscopic stricturotomy (ES). Relevant clinical data of patients were collected retrospectively. Outcomes included success rate, remission time, complications, and follow-up interventions. This observational study was followed up postoperatively to observe patient remission and recurrence rates.
RESULTS
Seventeen endoscopic strictures were created in 11 patients, achieving a 100% immediate success rate without any serious complications. During the follow-up period, stricture recurrence was observed in two patients, resulting in an endoscopic reintervention rate of 18.2%. Additionally, two patients required subsequent surgical intervention, with a surgical treatment rate of 18.2%. One patient experienced bowel obstruction 18 months post-ES and was successfully managed with conservative treatment without surgical intervention. The remission duration after the initial ES treatment was 10.1 ± 8.2 months, with a median remission time of 10 months.
CONCLUSION
ES is a safe and effective treatment for CD-related strictures and warrants further clinical promotion and application.
Novel surgical approach - cadaveric inferior vena cava graft reconstruction following leiomyosarcoma resection: A case report
Authors: AlOmran Hadeel A , AlMatar Bayan , AlMonsained Mohammed , Bojal Shoukat , Momani Hammam , AlQahtani Mohammed S 
Published: January 2025

BACKGROUND
Inferior vena cava (IVC) leiomyosarcomas are rare and aggressive tumors. Complete cure depends on achieving R0 resection, which often requires circumferential resection and reconstruction. Synthetic grafts have traditionally been used when venous continuity must be restored. However, the use of cadaveric IVC grafts for reconstruction has not been widely reported.
CASE SUMMARY
Herein, we present the case of a 64-year-old woman diagnosed with an intrahepatic IVC leiomyosarcoma with local invasion. The patient responded favorably to chemotherapy and subsequently underwent an en bloc right hepatectomy, retrohepatic IVC resection, and reconstruction with an interpositional cadaveric IVC graft. Serial imaging follow-ups until 2 years after the operation showed persistent patency of the graft and no graft-related complications.
CONCLUSION
Cadaveric IVC grafts are an alternative to synthetic grafts for reconstruction, with acceptable outcomes. Larger, long-term studies are necessary to validate these findings.
Gamma-glutamyl transferase-to-lymphocyte ratio as a prognostic marker in patients with hepatocellular carcinoma undergoing hepatectomy
Authors: Zhou Peng-Cheng , Huang Rui , Wang Hai-Tao , Yang Jun , Peng Jian-Dong , Fu Zi-Xuan , Liao Wen-Jun , Ma Hai-Qiang , Wu Lin-Quan , Li En-Liang 
Published: January 2025

BACKGROUND
We investigated the utility of gamma-glutamyl transferase-to-lymphocyte ratio (GLR) as a predictive indicator for postoperative survival in patients with hepatocellular carcinoma (HCC) across different time periods and developed a predictive model based on this.
AIM
To evaluate the prognostic accuracy of GLR for overall survival (OS) in patients with HCC and its impact over time.
METHODS
This study enrolled 301 patients with HCC treated with curative hepatectomy. Exclusion criteria included non-HCC hepatic malignancies, inadequate records, and prior cancer treatments. Baseline demographics, clinical features, and hematological parameters were recorded. Time-dependent receiver operating characteristic curve analysis was used to determine the optimal GLR threshold for survival prediction at 13 months. Statistical analyses included the Kaplan-Meier method, multivariate Cox regression, and the creation of a prognostic nomogram.
RESULTS
Out of 301 patients, 293 were eligible for analysis, with a male predominance (84.6%). High preoperative GLR correlated with several adverse clinical features. Optimal cutoff values for GLR were significantly associated with stratification of 13-month OS. Multivariate analysis identified age, liver enzymes, postoperative transarterial chemoembolization, Child-Pugh grade, and inflammatory markers as independent predictors of OS. Notably, GLR had a significant impact on long-term postoperative OS, with its influence becoming more pronounced over time.
CONCLUSION
GLR can serve as a potent prognostic tool for postoperative HCC management, particularly in predicting long-term outcomes.
Revista Completa Derecho UCT
Authors: Universidad Católica de Trujillo  
Published: January 2025

ARTÍCULOS
1. Aspectos problemáticos en la admisión de medios extemporáneos en el Proceso Civil Peruano
Problematic aspects in the admission of extemporanean means in the Peruvian Civil Process
2. Evaluación de la eficiencia del proceso inmediato en casos de flagrancia delictiva en Perú, una revisión sistemática
Evaluation of the efficiency of the immediate process in cases of criminal flagrancy in Peru, a systematic review
3. Problemática del despido incausado en el Perú
Problem of uncaused dismissal in Peru
4. Factores que inducen a funcionarios públicos para la comisión del delito de peculado, Red de Salud Coronel Portillo, 2023
Abstract factors that induce public officials to commint the crime of embezzlement, Coronel Portillo health network, 2023
5. Fundamentos de control en las pensiones alimenticias de menores de edad del Distrito Judicial de La Libertad, 2023
Fundamentals of control in the support of minors, of the Judicial District of La Libertad, 2023
Impacto da cirurgia bariátrica na condição de saúde bucal do paciente: uma revisão de literatura
Authors: Oliveira Izabelle Alves Mendes de , Félix Myria Conceição Cerqueira 
Published: January 2025

A obesidade é uma doença crônica caracterizada pelo acúmulo de adiposidade corpórea. A prevalência dessa enfermidade é considerada um problema de saúde pública no mundo: A dificuldade dos pacientes de seguirem métodos terapêuticos conservadores, a cirurgia bariátrica se tornou uma opção ágil e segura de tratamento. Porém, no pós-operatório, têm sido observadas algumas alterações sistêmicas e orais como, por exemplo: osteoporose, deficiência de vitamina D, xerostomia, erosão dental, perda dentária, cárie, doença periodontal, entre outros. Essas modificações orais são decorrentes da diminuição do pH da saliva, refluxo gastroesofágico, vômitos e da mudança de hábitos após a realização do procedimento. Este estudo, que tem por objetivo identificar as manifestações orais que podem se desenvolver no pós-operatório das cirurgias bariátricas. Os resultados evidenciaram que a cirurgia bariátrica proporciona melhorias sistêmicas relevantes para a condição de saúde geral do paciente; porém, pode potencializar situações de doença na cavidade oral, especificamente aumento das doenças periodontais, cáries, xerostomia, lesões não cariosas e perdas dentárias e de implantes Todas essas alterações bucais são decorrentes da modificação da rotina alimentar e da dieta, das regurgitações que acontecem pela alteração no trato gastrointestinal com o procedimento cirúrgico, desidratação e deficiência nutricional que afetam diretamente o arcabouço mineral dos tecidos de sustentação dentário. Como o número de cirurgias bariátricas vem aumentando ao longo dos anos, torna-se relevante identificar os problemas bucais que acometem esse grupo de pacientes no pós-operatório, com o intuito de possibilitar a elaboração de medidas de intervenção que visem melhorias da saúde bucal.
Principals' self-perception of their transformational leadership practices and its effects on Student academic performance in Sidama Region, Ethiopia.
Authors: DUKAMO DESSIE D , RJ (Nico) Botha 
Published: January 2025

Abstract
The study examined principals' transformational leadership practices and how they can affect student academic performance in Ethiopia's Sidama region. It employed a convergent parallel mixed research design. The quantitative part of the study used a modified MLQ-based questionnaire, while the qualitative phase used an open-ended semi-structured interview. The study's dependent variable was student academic performance, while the independent variable was principals' transformational leadership practices. The study targeted 95 public secondary schools in Ethiopia's Sidama region. The study used an appropriate sample approach and included 91 principals from 24 public secondary schools. In the qualitative phase, ten principals took part. An analysis of the gathered data was done using both descriptive and inferential statistics. The study's findings demonstrated that principals comprehend and practice transformational leadership. Furthermore, the study showed that the principal's transformational leadership techniques significantly and favorably affect students' academic performance, with an overall correlation value of r =.827 (p<.01).
The results of the linear multiple regression showed that 69.9% of the variation in the student's academic performance could be explained by modifications in the principal's transformational leadership approach. Furthermore, the study showed that principals in high-performing schools more frequently exhibit transformational leadership behaviors than in low-performing ones.
ANALISIS FRAMING PEMBERITAAN KASUS RASISME TERHADAP MAHASISWA PAPUA DI SURABAYA PADA MEDIA DARING DETIK.COM
Authors: Haryanto Dedy  , Andries Lionardo  , Krisna Murti  
Published: January 2025

Penelitian ini bertujuan untuk mengetahui bagaimana pembingkaian peristiwa yang dilakukan oleh Detik.com dalam memberitakan kasus rasisme yang terjadi terhadap mahasiswa Papua di Surabaya dengan menggunakan Teori Framing yang dikemukakan oleh Robert N. Entman. Adapun instrumen dalam teori ini adalah Define Problem (pendefinisikan masalah), Diagnose Causes (memperkirakan penyebab masalah), Make Moral Judgement (membuat keputusan moral atau nilai-nilai moral), dan Treatment Recommendation (menekankan penyelesaian). Metode yang diterapkan adalah metode kualitatif dengan menggunakan metode pengumpulan data melalui observasi terhadap berita yang dimuat pada laman Detik.com terkait pemberitaan kasus rasisme terhadap mahasiswa Papua di Surabaya periode 19 Agustus - 21 Agustus 2019. Berdasarkan hasil pengumpulan data, diperoleh 27 berita yang kemudian dibatasi pada 5 berita yang peneliti analisis. Hasil penelitian menunjukkan bahwa dalam pendefinisian masalah, Detik.com membingkai kasus tersebut sebagai dugaan rasisme sedangkan untuk penyebab masalah, Detik.com membingkai adanya provokator yang melakukan tindakan rasisme terhadap mahasiswa Papua. Dalam membuat keputusan moral, Detik.com menjelaskan agar kasus ini menjadi pembelajaran bagi masyarakat Indonesia dan menjadi peringatan bagi pemerintah. Rekomendasi terkait kejadian yang diberikan oleh Detik.com adalah agar pemerintah dan pihak-pihakterkait dapat mengusut tuntas kasus ini dan menghukum pelaku rasisme sesuai dengan hukum yang berlaku.
PEMANFAATAN INSTAGRAM SEBAGAI MEDIA DAKWAH (STUDI AKUN INSTAGRAM @YUKNGAJI)
Authors: Mochamad Syaefudin  , Aisyatul Khoriyah  
Published: January 2025

Media sosial berhasil mencapai popularitas paling tinggi di era serba digital sekarang. Salah satu yang paling di gandrungi oleh masyarakat global saat ini adalah media sosial intragram.Intagram merupakan media sosial berbasis gambar yang memberikan layanan berbagai foto atau video secara online. Instgram dapat mengunggah foto dengan menggunakan jaringan internet, sehingga informasi yang di sampaikan juga dapat diterima dengan cepat. Intagram dengan cepat mendapat popularitas dengan 800 juta pengguna pada september 2017. Penelitian ini termasuk jenis penelitian pustaka (library research) yang bersifat kualitatif deskriptif yang bertujuan untuk mendeskripsikan, menjelaskan dan memvalidasi temuan penelitian dengan data primer berupa lampiran kiriman dalam akun @yukngaji dan sumber data sekunder berupa dokumentasi buku serta internet. Sedangkan metode pengumpulan data yang dilakukan adalah metode dokumentasi kemudian di analisis menggunakan analisa kualitatif dan disimpulkan secara induktif. Hasil dari penelitian ini menjelaskan bahwa akun instagram @yukngaji memanfaatkan semua fitur yang tersedia dalam instagram sebagai media untuk menyebarkan pesan-pesan dakwah islam. Perkembanngan media sosial terutama instagram yang sangat pesat, kini banyak dimanfaatkan sebagai media dalam berdakwah bagi dai ataupun umat islam keseluruhan karena dakwah merupakan suatu kewajiban bagi umat islam.
Pelatihan Digital Marketing bagi Pedagang Kecil di Gampong Keude Karieng untuk Meningkatkan Kepuasan Pelanggan
Authors: Aisyi Rahadatul , Ummah Rizky , Humaira Rossa , Bila Sasal , Al Ghifari Aidil Fikri , Rambe Ahmad Safri Noor , Akmal Mulia , Asysyura Asysyura 
Published: January 2025

This study aims to evaluate digital marketing training and mentoring for micro-entrepreneurs in Gampong Keude Karieng, Meurah Mulia District, North Aceh Regency. This activity was designed to increase the capacity of local entrepreneurs by utilizing digital technology in developing businesses. This research used a descriptive qualitative approach with a type of participatory action research. Data collection techniques were conducted using questionnaires, direct observation, in-depth interviews, and documentation. Data analysis techniques are carried out by analyzing qualitative data and quantitative data. The method used is a phased training approach, which starts with Problem Identification, Training Planning, Training Implementation which is divided into four sessions with digital marketing material involving 15 participants aged between 24 to 40 years, Evaluation and Follow-Up. The results showed that the training successfully improved participants' understanding of the importance of digital marketing and its benefits for expanding market reach. However, there were challenges related to technological infrastructure, particularly unstable internet networks, as well as differences in motivation between young and more mature participants. The implications of this study suggest the importance of improving digital infrastructure in rural areas as well as the need for a more segmented approach based on age and experience to increase interest in entrepreneurship.
The Effects of Financial Literacy on the Financial Performance of Micro Businesses in Mezam Division
Authors: Takoutio Feudjio virginie 
Published: January 2025

Purpose: Over the years, the greatest desire of most people had been that of achieving high financial performance but the access to that requires the knowledge of financial literacy. This article had as aim to investigate the influence of financial literacy on the financial performance of micro businesses in Mezam. Our objective was achieved by breaking down financial literacy into three variables (debt management literacy, budgeting skills, and book keeping).
Methodology: Data collected through questionnaires were analyzed using the Ordinary Least Squares as estimation technique.
Findings: After regression, the results of the article revealed that all the three variables considered under financial literacy have positive and significant effect on the financial performance of micro businesses.
Unique Contribution to Theory, Policy and Practice: Therefore, to succeed in business and increase their financial performance, owners of micro business should make an effort to be train on how to manage their debt effectively, how to keep records and how to plan a budget.
Emerging Innovations in Pet Food Industry Sustainability, Nutrition, and Consumer Trends in 2024
Authors: Kumar Rishav , Sharma Ankit 
Published: January 2025

The pet food industry in 2024 is at a pivotal juncture, marked by transformative advancements in sustainability, nutritional science, and consumer-centric innovation. This review explores emerging trends that redefine pet nutrition, including the integration of alternative protein sources such as insects, algae, and yeast to address environmental and ethical challenges. The growing emphasis on eco-friendly manufacturing practices, such as the adoption of biodegradable packaging and local ingredient sourcing, reflects an industry-wide commitment to sustainability. Advances in functional nutrition are highlighted, showcasing products tailored to support gut health, joint care, and mental well-being, driven by breakthroughs in understanding the gut-brain axis. Technological innovations, including AI-driven formulation, DNA-based diet personalization, and precision fermentation, are enhancing product quality and sustainability. The rise of vegan and plant-based pet diets, alongside evolving consumer preferences for transparency and premium offerings, underscores a shift toward ethical and health-conscious consumption. This paper critically examines these developments, their market implications, and identifies avenues for future research to support industry growth and innovation.sustainability; alternative proteins; functional nutrition; technology; consumer trends
Study of the effect of the fermentation process on the biochemical characteristics of Vigna radiata
Authors: Makenova A. A. , Mussayeva S. D. 
Published: January 2025

This article provides a comparative assessment of the chemical composition, the content of vitamins, minerals and amino acid composition of ordinary and fermented mung bean seeds, Vigna radiata. The seeds of Vigna radiata of the domestic selection "Zhasyl Dan" are the object of research. In order to increase the biological values of Vigna radiata seeds and improve their biochemical composition, a fermentation process was carried out. The effect of the fermentation process on the biochemical and amino acid composition of Vigna radiata seeds was studied. The fermentation process of mung bean seeds occurs due to the activation of a number of biochemical compounds and enzymes contained in the seed itself. The main substances that participate in and influence fermentation are amylases, proteases, lipases, gibberellins and other phytohormones such as auxins and cytokinins, polyphenols and antioxidants. Fermentation of Vigna radiata seeds was carried out at room temperature 200 C for 72 hours. The seeds were placed in a plastic container, then covered with drinking water also at room temperature. The water level was monitored every 12 hours. The research was carried out in the accredited testing laboratory "Regional Testing Laboratory of Engineering profile "Structural and Biochemical Materials" on the basis of M. Auezov South Kazakhstan University, Shymkent. As a result of the study, it was found that fermentation of Vigna radiata seeds leads to an improvement in physico-chemical properties. This is due to the strengthening of the amino acid composition of the Vigna radiata seed, especially the effect of fermentation has a positive effect on essential amino acids. It was found that as a result of fermentation, the level of essential amino acids increased in the following order: valine – by 25.4%, leucine – by 32.8%, phenylalanine – by 27.7%, threonine – by 44.9%. There was also a decrease in the indicators of anti-nutritional substances - in particular, there was a decrease in the amount of oligosaccharides. Due to the activation of the enzyme systems of the seed itself, their nutritional and biological value increases.