bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ursolic acid inhibits autophagy-dependent neuronal cell death by reducing oxidative stress levels in an in vitro model of Parkinson's disease
Authors: Gao Jinyong , Lei BingHai , He Hui , Xi Di , Wu Qian , Wang XiaoDong , Li Na , Tian ZhenZhen , Zhu Qing , Yu Yanyan 
Published: March 2023

Abstract
Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. The pathogenesis of PD is complicated, resulting from the comprehensive action of many factors [3-5]. In addition, increasing studies have shown that autophagy plays an important role in the development of PD [6-9]. We found that Rotenone caused ROS to build up, which led to apoptosis. However, it is still not clear whether AMPK is involved in Rotenone-induced inhibition of autophagy and apoptosis. We found that Rotenone induced a significant increase in mitochondrial oxidative stress and activated AMPK signaling, leading to a decrease in intracellular autophagy and then apoptosis. The inhibition of autophagy, oxidative stress, and apoptosis induced by Rotenone could be significantly reversed by reducing the oxidative stress level with ursolic acid. In addition, the passivation of AMPK with Ad-dnAMPKα significantly alleviate AMPK phosphorylation, autophagy inhibition, oxidative stress, and apoptosis induced by Rotenone. In conclusion, Rotenone leads to autophagosome-dependent accumulation of apoptosis by inhibiting AMPK-impaired neuronal autophagy flux. Our results highlight that inhibiting AMPK activity and oxidative stress using ursolic acid to improve autophagy levels is a promising strategy to combat Rotenone-induced neurotoxicity.
Comparative study of interaction energies between αIIbβ3 integrin and the peptidic, peptidomimetic and non-peptidic ligands by quantum mechanics FMO-PIEDA calculations
Authors: Kóňa Juraj 
Published: March 2023

Abstract
Integrins are one of the major families of cell adhesion receptors. The recognition of the vital roles of integrins in various diseases revealed their therapeutic potential. To better understand an adhesion mechanism of integrins, pair interaction energy decomposition analysis (PIEDA) along the two-body fragmented molecular orbital (FMO) method was used. Interaction energies were evaluated between the amino acid residues including Mg2+ and Ca2+ ions at ligand-binding site of αIIbβ3 integrin and two peptide chains with the Ala-Gly-Asp and the Arg-Gly-Asp binding motifs, a cyclic peptide (eptifibatide), peptidomimetic ligands (tirofiban and L-739758) and poly(L-lactic acid) chain (PLA). The results indicate that Mg2+ and Ca2+ ions together with Asp224A, Asn215B, Asp159A and Lys125B of αIIbβ3 are the most important residues for a binding of the peptidic ligands while for the peptidomimetic ligands and PLA, interactions with Ca2+ ions are less significant than those with amino acid residues of αIIbβ3. For all complexes a dominant part of interaction energy comes from electrostatic interactions. Based on optimized geometries at the quantum mechanics/molecular mechanics (QM/MM) level an interaction pattern predicted for PLA was compared with the native peptidic ligands.
Self-efficacy of advanced cancer patients for participation in treatment related decision- making: the ACTION study.
Authors: Yildiz Berivan , Korfage Ida J. , Deliens Luc , Preston Nancy , Miccinesi Guido , Ceh Hana Kodba , Pollock Kristian , Johnsen Anna Thit , Delden Johannes van , Rietjens Judith , Heide Agnes van der 
Published: March 2023

Abstract
Purpose: Many patients prefer an active role in making decisions about their care and treatment, but participating in such decision-making is challenging. The aim of this study was to investigate whether patient reported outcomes (quality of life and patient satisfaction), patients’ coping strategies, sociodemographic and clinical characteristics were associated with self-efficacy for participation in decision-making among patients with advanced cancer.
Methods: We used baseline data from the ACTION trial of patients with advanced colorectal or lung cancer from six European countries, including scores on the Decision-making Participation Self-efficacy (DEPS) scale, EORTC QLQ-C15-PAL questionnaire and the EORTC IN-PATSAT32 questionnaire. Multivariable linear regression analyses were used to examine associations with self-efficacy scores.
Results: The sample included 660 patients, mean age 66 years (SD 10). Patients had a mean score of 73 (SD 24) for self-efficacy. Problem-focused coping (B 1.58 (95% CI 0.91 to 2.25)), better quality of life (B 3.60 (95% CI 2.22 to 4.98)) and more patient satisfaction (B 8.02 (95% CI 6.02 to 10.10)) were associated with a higher level of self-efficacy. Patients in the Netherlands had a higher level of self-efficacy than patients in Belgium ((B 10.77 (95% CI 5.47 to 16.07)), whereas Italian patients had a lower level ((B -7.38 (95% CI -12.94 to -1.83)) than those in Belgium.
Conclusion: Coping style, quality of life and patient satisfaction with care were associated with self-efficacy for participation in decision-making among patients with advanced cancer. These factors are important to consider for healthcare professionals when supporting patients in decision-making processes.
Enhanced low-temperature activity of toluene combustion over Ce-modified Co3O4 catalyst by weakening Co−O strength
Authors: Cheng Lijun , Fan Tingting , Mao Kangping , Chang Hong , Ren Xiaoli , Zhang Biao , Jiang Yi 
Published: March 2023

AbstractIn this study, a series of Ce-modified Co3O4catalysts were prepared by co-precipitation. The influence of Ce/(Ce + Co) ratio on the catalyst microstructure and catalytic oxidation performance of toluene were systematically investigated. The results showed that introduction of Ce lead to great changes in the structure with a smaller crystallite size of Co3O4and larger specific surface area of the catalyst. More importantly, Ce dopant can significantly weaken the Co-O bond strength and enhance the activity of oxygen species, thus improving the degradation efficiency of toluene. Due to the weakest Co-O bond strength, abundant oxygen vacancy, and the strongest reducibility of Co3+, CoCe0.05Oxcatalyst exhibited the best catalytic oxidation activity of toluene (T90 = 225℃). In addition, CoCe0.05Oxcatalyst presented good stability and repeatability during 30 h durability test under water vapor.
Effectiveness model of automatic machine translation of publicity texts based on deep learning
Authors: Fan LU 
Published: March 2023

Abstract
The constant emergence and rapid popularization of various intelligent technologies have brought a lot of convenience to people's lives, and also changed people's usual way of life. The use of machine automatic translation technology can greatly improve the efficiency of the analysis of publicity text information, and it is very helpful for people to deal with publicity text. The emergence of text machine automatic translation technology has brought convenience and new ideas to people's processing of large amounts of data. In the process of application, this technology will first model and analyze the semantic information contained in the text to be processed, and then output the information that people need according to their data processing requirements. In order to more clearly illustrate the effect of automatic text machine translation technology in practical applications, this paper selects two different types of text models, compares and analyzes the actual performance of this technology, and conducts a comparative study on the effect of Seq2Seq model and pre training model in translating text information. Combined with the relevant theory of deep learning, this paper illustrates the advantages and differences of the two models in translation effects, It provides scientific reference for the improvement of automatic translation model of publicity texts.
Existence of bound state solutions for p-Laplacian equation with critical growth
Authors: Dai Tingting , Ou Zengqi , Lv Ying 
Published: March 2023

Abstract
Note: Please see pdf for full abstract with equations.
In this paper, we study the following p-Laplacian problem
−Δpu + V(x)|u|p−2u = |u|p*−2u + α(x)|u|q−2u, x ∈ RN,
u ∈ W1,p(RN),
where Δp := div(|∇u|p−2∇u) is the p-Laplacian operator, V is a nonnegative function, N > p2, 1 < p < q < p* and p* = Np/N−p is the Sobolev critical exponent. Under appropriate assumptions on V and a, we prove that this problem has at least two distinct bound state solutions.
Temporal changes in green spaces of Guwahati city, Assam, India with special reference to tree community structure of selected urban green patches
Authors: Goswami Maitreyee , Bayan Jijnyasha , Dutta Uma , Hazarika Arup Kumar , Sarma Kuladip 
Published: March 2023

Abstract
Urban green spaces are of utmost necessity in the context of urban ecology and there is an ever-growing list of challenges being faced by these due to various anthropogenic activities. The current study aims to estimate the temporal changes in green spaces of Guwahati Metropolitan Development Authority (GMDA) and also investigate the tree community structure of three selected green patches. The change detection analysis of the identified green spaces has been done by comparing Normalized Difference Vegetation Index (NDVI) map of the year 2022 with that of the year 1972 using satellite images for both the years. The NDVI maps have been reclassified into three threshold categories viz., No Vegetation (NV), Moderate Vegetation (MV) and High Vegetation (HV). The results show changes in the area of the selected green patches between 1972 and 2022. Whereas, the tree community structure in the three selected patches indicates low diversity of plant species. Subsequently, the categories of the green spaces viz., NV, MV and HV also show significant changes over the last 50 years. The result of the current study prioritizes patch wise management of urban green spaces in the Guwahati city with the help of both remotely sensed and ground data. Thus, the present study can significantly contribute in conservation and management of urban greeneries based on landscape management strategies.
Medical testing services’ quality enhancement with discrete-event simulation
Authors: Mira Jorge , Ferreira Diogo Cunha , Caldas Paulo , Varela Miguel 
Published: March 2023

Abstract
In recent years, the demand for health care has increased owing to the ongoing introduction of new health problems and the intensification of existing illnesses. As research in this area progresses, knowledge becomes the primary motivation for patients to adopt a better quality of life. Consequently, many health units have struggled to develop solutions to manage excessive demand while maintaining a high quality of service to enhance patient satisfaction and boost revenues. One of these tactics is using simulation models as a method of operational research to analyze the flow of patients and predict potential solutions to enhance resource efficiency while decreasing waiting time. This work aims to develop and demonstrate a simulation model that replicates the functioning of a hospital unit. For this purpose, data derived from the health services of the Imaging Department of a private hospital, located in Lisbon, Portugal, were used. This model will replicate the daily flow that this department is subjected to by its patients and personnel and depict how the system evolves due to the management of the department's number of resources and examination rooms. At the end of the analyses, several solutions are presented and discussed, from level to level, concerning improvements in the performance of services, resources and patients. However, only the increase in one unit of examination rooms translates into a huge positive impact on waiting times in the respective queues.
Comparison of growth performance and biochemical components between low salinity tolerant hybrid and imported populations of Pacific white shrimp, Penaeus vannamei
Authors: Ye Yucong , Zhang Junya , Yang Ying , Tian Jiangtao , Xu Wenyue , Zhu Bihong , Du Xinglin , Huang Yizhou , Li Yiming , Zhao Yunlong 
Published: March 2023

Abstract
Penaeus vannamei, a high yield economical shrimp, is confronting germplasm degradation in the brine culture environments found in China. Genetic improvement by hybridization is an effective way to solve this problem. In this study, EB and CE hybrid was obtained from Guam wild B, C and E families from Shanghai Ocean University. EB and CE were used as parents to obtain genetic hybrids suitable for freshwater culture. The control group was shrimp imported from the Hainan Lutai Company. The two groups of shrimp were cultured for 3 months under salinities of 1‰, 5‰, and 15‰. Growth performance-related indicators, biochemical composition, and growth-related gene expression were examined. The results showed that at salinities of 1‰ and 5‰, the survival rate and growth performance of the low salt breeding group were better than those of the imported population. The digestive enzyme activity in the low salt breeding group was higher, which was consistent with its better growth performance, and was also associated with higher triglyceride, total cholesterol, and glycogen content. Lower levels of lactic acid indicated less anaerobic metabolism and better adaptability to the environment. The amino acid analysis of fatty acids showed that levels of essential amino acids and high unsaturated fatty acids were both higher in the low-salt breeding group than in the imported shrimp cultured in low salinity. The expression levels of genes associated with growth and hair removal were also higher in the low salt breeding group than in the imported shrimp group. The results indicated that the hybrid shrimp showed better growth performance and nutritional advantages compared with the imported shrimp under salinities of 1‰ and 5‰. This research provided a valuable reference for subsequent genetic breeding and shrimp culture.
METTL14-dependent m 6 A modification of circUGGT2 drives gastric cancer progression by sponging miR-186-3p and upregulating MAP3K9
Authors: Chen Xiao-Yu , Yang Yan-Ling , Chen Zhao-Yu , Yu Yi , Chen Ming , Fan Hui-Ning , Zhang Jing , Zhu Jin-Shui 
Published: March 2023

Abstract
Background: N6-methyladenosine (m6A) RNA modification has been shown to act fundamental roles in cancer progression. However, the underlying mechanisms by which m6A modification of circRNAs contributes to gastric cancer (GC) remain unknown.
Methods: METTL14-mediated m6A modification of circRNAs was identified by an m6A-circRNA epi-transcriptomic microarray and verified by methylated RNA immunoprecipitation (MeRIP) and m6A dot blot. Cell bio-behaviors were measured by molecular oncology experiments in vitro and in vivo. The mechanisms underlying gastric tumorigenesis were conducted by RIP, luciferase gene report, RT-qPCR. and Western blot analyses. The prognostic significance was analyzed by FISH and TCGA dataset.
Results: We found that hsa_circ_0030632 (circUGGT2) was a predominant m6A target of METTL14, and METTL14 knockdown (KD) reduced circUGGT2 m6A levels but increased its mRNA levels. circUGGT2 KD impaired cell growth and metastasis in vitro and in vivo, but circUGGT2 overexpression prompted these effects. Furthermore, circUGGT2 was validated to sponge miR-186-3p and upregulate MAP3K9 and could abolish METTL14-caused miR-186-3p upregulation and MAP3K9 downregulation in GC cells. circUGGT2 negatively correlated with miR-186-3p expression and harbored a poor prognosis in patients with GC.
Conclusion: Our findings unveil that METTL14-dependent m6A modification of circUGGT2 promotes GC progression by sponging miR-186-3p and upregulating MAP3K9.
First-principles Study on α/β/γ-FeB 6 Monolayers as Potential Gas Sensor for H 2 S and SO 2
Authors: Wang Chao , Zhang Yuhang , Huang Rongfang , Wei Xueqian , Zhao Xiaoxiao , Geng Shiyi , Xue Yuxin , Hou Jianhua , Duan Qian 
Published: March 2023

Abstract
The adsorptions of toxic gases SO2 and H2S on 2D α/β/γ-FeB6 monolayer were investigated using density functional theory calculations. To analyze the interaction between gas molecule H2S/SO2 and α/β/γ-FeB6 monolayer, we calculated adsorption energy, adsorption distance, Mullikan charge, charge density difference, band structure, density of states, work function and theoretical recovery time. The adsorption energies show that H2S/SO2 is chemisorbed on α/β-FeB6 while H2S/SO2 is physiosorbed on γ-FeB6 monolayer. As a result, γ-FeB6 has short recover time for H2S (3.40×10− 4 s)/SO2 (5.09×10− 3 s) due to modest adsorption. Therefore, γ-FeB6 may be a promising candidate for reusable H2S/SO2 sensor at room temperature. Although H2S is chemisorbed on α/β-FeB6, as the working temperature rises to 500 K, the recovery time of α/β-FeB6 for H2S can decrease to 1.34×10− 2 s and 5.23×10− 1 s, respectively, which are well within the detectable range. So, α/β-FeB6 monolayer also may be good candidate for H2S gas sensor.
Bone marrow-derived c-kit positive stem cell administration protects against diabetes-induced nephropathy in a rat model by reversing PI3K/AKT/GSK-3β pathway and inhibiting cell apoptosis
Authors: Ghaffari-Nasab Arshad , Ghiasi Fariba , Keyhanmanesh Rana , Roshangar Leila , Korjan Elnaz Salmani , Nazarpoor Navid , Bavil Fariba Mirzaei 
Published: March 2023

Abstract
Stem cell-based therapy has been proposed as a novel therapeutic strategy for diabetic nephropathy. This study was designed to evaluate the effect of systemic administration of rat bone marrow-derived c-kit positive (c-kit⁺) cells on diabetic nephropathy in male rats, focusing on PI3K/AKT/GSK-3β pathway and apoptosis as a possible therapeutic mechanism. Twenty-eight animals were randomly classified into four groups: Control group (C), diabetic group (D), diabetic group, intravenously received 50 μl phosphate-buffered saline (PBS) containing 3×105 c-kit- cells (D+ckit-); and diabetic group, intravenously received 50 μl PBS containing 3×105 c-Kit positive cells (D+ckit+). Control and diabetic groups intravenously received 50 μl PBS. C-kit+ cell therapy could reduce renal fibrosis, which was associated with attenuation of inflammation as indicated by decreased TNF-α and IL-6 levels in the kidney tissue. In addition, c-kit+ cells restored the expression levels of PI3K, pAKT, and GSK-3β proteins. Furthermore, renal apoptosis was decreased following c-kit+ cell therapy, evidenced by the lower apoptotic index in parallel with the increased Bcl-2 and decreased Bax and Caspase-3 levels. Our results showed that in contrast to c-kit– cells, the administration of c-kit+ cells ameliorate diabetic nephropathy and suggested that c-kit+ cells could be an alternative cell source for attenuating diabetic nephropathy.
Convergence Analysis for Elliptic Quasivariational Inequalities
Authors: Barboteu Mikaël , Sofonea Mircea 
Published: March 2023

Abstract
We deal with a class of elliptic quasivariational inequalities with constraints in a reflexive Banach space. We use arguments of monotonicity, convexity and compactness in order to prove a convergence criterion for such inequalities.This criterion allows us to consider a new well-posedness concept in the study of the corresponding inequalities,which extends the classical Tykhonov and Levitin-Polyak well-posedness concepts used in the literature.Then, we introduce a new penalty method, for which we provide a convergence result. Finally, we consider a variational inequality which describes the equilibrium of a spring-rods system, under the action of external forces.We apply our abstract results in the study of this inequality and provide the corresponding mechanical interpretations. We also present numerical simulations which validate our convergence results.
2010 Mathematics Subject Classification: 47J20, 49J27, 49J40, 49K20, 74M15, 74M10.
HBWO-CML: An energy-efficient Hybrid Black Widow Optimisation and a Combined Machine Learning approach for VM Placement
Authors: Goyal Sahul , Awasthi Lalit Kumar 
Published: March 2023

Abstract
Cloud data centers remove the hardware barriers for the world with enormous storage and computing capabilities and provide access from anywhere over the internet with the concept of virtual machines (VM) and physical machines (PM). These cloud centers raise the problem of lack of resource utilisation and energy waste. These drawbacks have led many researchers to propose VM placement techniques that improve resource utilization and energy consumption. The research proposes VM migration/consolidation and host selection techniques to improve the resource utilisation of cloud centers. This research suggests hybrid black widow optimization (HBWO) and a combined machine learning model to mitigate the problem of cloud centers. HBWO optimizes the VM placement sub-process using an evolutionary approach and a combined machine-learning-based model to predict the over and under-utilised hosts. The effectiveness of the proposed approach was analysed and compared with a Power-Aware Best-Fit Decrease (PABFD) approach and a Particle Swarm Optimization (PSO) approach. The proposed approach improves energy utilisation by 30-40\% over PABFD and 20-15\% over PSO. Moreover, the combined approach of HBWO and machine learning improves the overall performance by 40-50\% compared to PABFD and 20-30\% compared to PSO.
Economies of Scale in Food and Housing Expenditure in Iranian Households
Authors: Mehrjou Saeed , Bakhshoodeh Mohammad 
Published: March 2023

Abstract
Household scale economics are plausibly attributed to shared household public goods that make larger households better off at the same level of per capita resources. This paper examines the role of food and housing from co-residence and economies of scale in the allocation of Iranian household expenditure. Using seemingly unrelated regression model, for 2011 and 2021 to prediction that in the presence of shared food and housing. Our method (solely) exploits preference information revealed by a cross-section of household observations while accounting for fully unobserved preference heterogeneity. We find that scale economies changed significantly from 2011 to 2021 for expenditure categories of food and housing, but not all trends in scale economies are consistent with theoretical predictions. The results indicated that the economies of scale is recognized to be higher in housing group than in the food group in both time periods. However, it has decreased within a decade and intensified by the lack of appropriate government policy. In this context, the government's policies to encourage the population growth has failed and the population encountered a low growth rate. Thus, providing support and welfare policy packages such as increasing income policy and household support insurance, as well as assistance in providing housing, are prioritized due to the economies of scale in housing.
Household scale economics are plausibly attributed to shared household public goods that make larger households better off at the same level of per capita resources. This paper examines the role of food and housing from co-residence and economies of scale in the allocation of Iranian household expenditure, for 2011 and 2021, by using seemingly unrelated regression. Our method exploits preference information revealed by a cross-section of household observations while accounting for fully unobserved preference heterogeneity. We find that scale economies changed significantly from 2011 to 2021 for expenditure categories of food and housing and are consistent with theoretical predictions. The results indicated that the economies of scale are recognized to be higher in housing group than in the food group in both time periods. However, it has decreased within a decade and intensified by the lack of appropriate government policy. In this context, the government's policies to encourage the population growth has failed and the population encountered a low growth rate. Thus, providing support and welfare policy packages such as increasing income policy and household support insurance, as well as assistance in providing housing, are prioritized due to the economies of scale in housing.