bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intensive care photoplethysmogram datasets and machine-learning for blood pressure estimation: Generalization not guarantied
Authors: Weber-Boisvert Guillaume , Gosselin Benoit , Sandberg Frida 
Published: March 2023

The large MIMIC waveform dataset, sourced from intensive care units, has been used extensively for the development of Photoplethysmography (PPG) based blood pressure (BP) estimation algorithms. Yet, because the data comes from patients in severe conditions—often under the effect of drugs—it is regularly noted that the relationship between BP and PPG signal characteristics may be anomalous, a claim that we investigate here. A sample of 12,000 records from the MIMIC waveform dataset was stacked up against the 219 records of the PPG-BP dataset, an alternative public dataset obtained under controlled experimental conditions. The distribution of systolic and diastolic BP data and 31 PPG pulse morphological features was first compared between datasets. Then, the correlation between features and BP, as well as between the features themselves, was analysed. Finally, regression models were trained for each dataset and validated against the other. Statistical analysis showed significant p<0.001 differences between the datasets in diastolic BP and in 20 out of 31 features when adjusting for heart rate differences. The eight features showing the highest rank correlation ρ > 0.40 to systolic BP in PPG-BP all displayed muted correlation levels ρ < 0.10 in MIMIC. Regression tests showed twice higher baseline predictive power with PPG-BP than with MIMIC. Cross-dataset regression displayed a practically complete loss of predictive power for all models. The differences between the MIMIC and PPG-BP dataset exposed in this study suggest that BP estimation models based on the MIMIC dataset have reduced predictive power on the general population.
Structural and signaling proteins in the Z-disk and their role in cardiomyopathies
Authors: Noureddine Maya , Gehmlich Katja 
Published: March 2023

The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the actin-rich thin filaments and plays a crucial role in maintaining the mechanical stability of the cardiac muscle. A multitude of proteins interact with each other at the Z-disk and they regulate the mechanical properties of the thin filaments. Over the past 2 decades, the role of the Z-disk in cardiac muscle contraction has been assessed widely, however, the impact of genetic variants in Z-disk proteins has still not been fully elucidated. This review discusses the various Z-disk proteins (alpha-actinin, filamin C, titin, muscle LIM protein, telethonin, myopalladin, nebulette, and nexilin) and Z-disk-associated proteins (desmin, and obscurin) and their role in cardiac structural stability and intracellular signaling. This review further explores how genetic variants of Z-disk proteins are linked to inherited cardiac conditions termed cardiomyopathies.
A highly efficient genetic transformation system for broccoli and subcellular localization
Authors: Zhao Yongyu , Yang Dongxu , Liu Yumei , Han Fengqing , Li Zhansheng 
Published: March 2023

IntroductionAgrobacterium-mediated genetic transformation has been widely used for the identification of functional genes and regulatory and developmental mechanisms in plants. However, there are still some problems of low genetic transformation efficiency and high genotype dependence in cruciferous crops.MethodsIn this study, broccoli, a worldwide Brassica crop, was used to investigate the effects of genotype, explant type, concentration of hygromycin B used during seedling selection, overexpression vector type, RNAi and CRISPR/cas9 on the genetic transformation efficiency. At the same time, two vectors, PHG-031350 and PHG-CRa, were used for subcellular localization of the glucoraphanin synthesis-related gene FMOGS-OX5 and clubroot resistance gene by a PEG-Ca2+-mediated transient transformation system for broccoli protoplasts. Finally, the Agrobacterium-mediated genetic transformation system of broccoli was optimized and improved.Results and DiscussionThis study showed that hypocotyl explants are more suitable for Agrobacterium-mediated transgene and CRISPR/Cas9 gene editing of broccoli. In contrast to previous studies, we found that 5 mg/L hygromycin B was more advantageous for the selection of resistant broccoli sprouts, and genotype 19B42 reached the highest transformation rate of 26.96%, which is higher than that in Brassica oleracea crops. In addition, the inbred line 19B42 successfully achieved high genetic transformation of overexpression, RNAi and CRISPR/Cas9 vectors; thus, it is powerful recipient material for the genetic transformation of broccoli. Subcellular localization proved that the glucoraphanin metabolism-related gene Bol031350 and clubroot resistance gene CRa were both expressed in the cytoplasm and nucleus, which provided a scientific basis for studying the regulation of glucosinolate metabolism and clubroot resistance in cruciferous crops. Therefore, these findings will provide new insight into the improvement of the genetic transformation and molecular breeding of Brassica oleracea crops.
The cross-cultural adaptation, validity, and reliability of the Spanish version of the Fremantle Back Awareness Questionnaire
Authors: García-Dopico Nuria , De La Torre-Luque Alejandro , Wand Benedict Martin , Velasco-Roldán Olga , Sitges Carolina 
Published: March 2023

IntroductionIn chronic low back pain (CLBP), disturbed body image has been highlighted as a contributor to the condition and a potential target for treatment. The Fremantle Back Awareness Questionnaire (FreBAQ) allows its assessment. Following international guidelines for the cross-cultural translation of questionnaires, we aimed to translate the FreBAQ into Spanish (FreBAQ-S) and validate the new questionnaire in a sample of Spanish-speaking people with CLBP.MethodsTwo hundred and sixty-four adults with CLBP (91 males) and 128 healthy controls (34 males) completed an online form including the FreBAQ-S and questionnaires related to the pain experience. All participants were Spanish and no gender identities differing from biological sex were reported. A week later, 113 CLBP participants and 45 healthy controls (41 and 13 males, respectively), re-answered the FreBAQ-S to evaluate test–retest reliability. Confirmatory factor and multigroup analysis assessed the scale consistency on the patient sample. Discriminant and convergent validity were explored by between-group differences and the relationship with clinical characteristics. Reliability relied on Cronbach’s alpha estimates and test–retest (intraclass correlation coefficient, standard error of measurement, minimal detectable change).Results and discussionConfirmatory factor analysis showed a one-factor structure of the questionnaire, without supporting evidence for item deletion (CFI = 0.97; TLI = 0.96; RMSEA = 0.06; SRMR = 0.07; SRMRu = 0.064). Multigroup analyses do not support mean invariance between groups regarding health condition or sex. The FreBAQ-S demonstrated good discriminant and convergent validity, internal consistency (α = 0.82), and test–retest reliability (ICC = 0.78; SE = 3.41; MDC = 5.12). The FreBAQ-S is a valid and reliable tool to assess back awareness in clinical and non-clinical samples.
Effectiveness of mindfulness training on pregnancy stress and the hypothalamic–pituitary–adrenal axis in women in China: A multicenter randomized controlled trial
Authors: Wang Shulei , Zhang Chen , Sun Mengyun , Zhang Daming , Luo Ying , Liang Kairu , Xu Tao , Pan XiaoPing , Zheng Ruimin , Shangguan Fangfang , Wang Jia 
Published: March 2023

IntroductionIn the past two decades, mindfulness-based intervention programs have gradually become popular.Many studies have confirmed that these programs can effectively alleviate prenatal stress and negative emotion.The mindfulness-based stress-buffering hypothesis suggests that mindfulness training can induce changes in the levels of the cortisol secreted by the HPA axis, thereby reducing stress susceptibility. However, to date, only a few high-quality evidence-based medical studies have analyzed the effect of the mindfulness-based intervention in a maternal population.Thus, this study investigated the effects of a mindfulness-based psychosomatic intervention on pregnancy stress and the HYPERLINK “javascript:;” hypothalamic-pituitary-adrenal (HPA) axis of pregnant Chinese women.MethodsWomen experiencing first-time pregnancy (n = 117) were randomly allocated to the intervention group or parallel active control group, and data were collected at baseline and post-intervention periods. The participants completed questionnaires regarding mindfulness and pregnancy stress. Saliva samples was collected at the time of waking up, and 30, 45, and 60 min after waking up for analyzing the salivary cortisol levels. We analyzed differences between the two groups and changes within the same group before and after the intervention.Results and discussionA total of 95 participants completed the trial. Compared with the parallel active control group, the intervention group exhibited lower levels of stress after the intervention (P = 0.047). For HPA-axis-related indicators after the intervention, Delta value (P = 0.01) and AUCM value (P = 0.031) of the intervention group were significantly higher than that of the control group. Mindfulness-based interventions effectively reduced the level of pregnancy stress and adjusted the HPA axis function in pregnant women in China.Clinical Trial Registrationhttps://www.chictr.org.cn, identifier ChiCTR 2000033149.
The influence of parental awareness of the “Chinese double reduction” policy on junior high school students’ extracurricular physical exercise
Authors: Liu Ping , Chen Jin , Shen Yangyang , Lou Hu 
Published: March 2023

ObjectiveIn this study, we aimed to explore the relationship between parental cognitive awareness (criticality, disruption and novelty cognition) of DBR, educational anxiety, and attitudes toward students’ physical exercise and students’ extracurricular physical exercise so as to construct and verify a conditional process model.MethodsWe adopted a stratified random cluster sampling approach and conducted a nationwide questionnaire survey with 2,700 junior high school students and their parents across 9 provinces, municipalities and autonomous regions.ResultsParents generally had a certain degree of cognitive awareness of DBR. Criticality cognition and disruption cognition had a significant positive impact on junior high school students’ extracurricular physical exercise (β = 0.24, p &lt; 0.01; β = 0.04, p &lt; 0.05), but the effect of novelty cognition was not significant (β = −0.04, p = 0.06). Parents’ educational anxiety played a significant mediating role in parents’ cognition of DBR and students’ extracurricular physical exercise (criticality cognition: β = 0.10, 95% CI: 0.03–0.06; disruption cognition: β = 0.37, 95% CI: 0.31–0.42). Parents’ attitude toward students’ exercise also played a significant positive moderating effect in the mediation model (criticality cognition: β = 0.014, 95% CI: 0.002–0.031; disruption cognition: β = 0.010, 95% CI: 0.007–0.013).ConclusionParents’ novelty, disruption, and criticality cognition of DBR have different effects on parents’ education anxiety and students’ extracurricular physical exercise, in which parental educational anxiety mediates the influence of DBR cognition on students’ extracurricular physical exercise, while attitudes toward students’ extracurricular physical exercise positively moderates the mediating effect.
CBT4CBT web-based add-on treatment for cocaine use disorder: Study protocol for a randomized controlled trial
Authors: Mallorquí-Bagué Núria , Palazón-Llecha Alba , Madre Mercè , Batlle Francesca , Duran-Sindreu Santiago , Trujols Joan 
Published: March 2023

BackgroundCocaine use disorder (CUD) is a chronic condition that presents high relapse rates and treatment dropouts. Web-based interventions have proven to be effective when optimizing face-to-face treatments in different mental health conditions and have the potential to optimize current CUD treatments. However, web-based interventions in addictive behaviors are still limited. The aim of this study is to evaluate whether adding a web-based cognitive behavioral therapy (i.e., CBT4CBT) to standard CUD treatment, improves treatment outcomes in a Spanish sample of patients with severe CUD (which requires inpatient treatment). Additionally, we aim to explore predictive factors of treatment response and treatment gender-related differences.MethodsAll individuals coming for inpatient cocaine detoxification who meet the inclusion criteria will have the possibility to be part of the study. The participants of this open-label randomized controlled clinical trial (RCT) will be allocated to treatment as usual (TAU) or TAU+CBT4CBT after the hospitalization for cocaine detoxification. During the inpatient treatment they will all receive an individualized psychological intervention. There will be six time point assessments: at 48–72 h of starting inpatient treatment, at the end of inpatient treatment and before starting day care and outpatient treatment, at the end of the 8 weeks CTB4CBT / TAU arm treatment and at three follow-up time points (1-, 3-, and 6-months post-treatment).DiscussionTo the best of our knowledge, this is the first RCT that explores the efficacy of adding a web-based cognitive behavioral therapy to usual CUD treatment with patients of a clinical sample in Europe.Trial registrationIIBSP-CTB-2020-116, NCT05207228. Submitted 8th of April 2021, posted 26 st of January 2022. https://clinicaltrials.gov/ct2/show/NCT05207228?cond=Cocaine+Use+Disorder&amp;draw=2&amp;rank=1.
Effect of religious fatalism and concern about new variants on the acceptance of COVID-19 vaccines
Authors: Mamani-Benito Oscar , Farfán-Solís Rosa , Huayta-Meza Mariné , Tito-Betancur Madona , Morales-García Wilter C. , Tarqui Edison Effer Apaza 
Published: March 2023

IntroductionTo protect public health, it is important that the population be vaccinated against COVID-19; however, certain factors can affect vaccine acceptance.ObjectiveThe objective of this study was to determine whether religious fatalism and concern about new variants have a significant effect on the acceptance of COVID-19 vaccines.MethodologyAn explanatory study was conducted with 403 adults of legal age captured through non-probabilistic convenience sampling in vaccination centers in the 13 health networks of the Regional Health Directorate of Puno, Peru. Data were collected through a brief scale of religious fatalism, a scale of acceptance of vaccines against COVID-19 and a scale of concern about a new variant of COVID-19.ResultsThe proposed model obtained an adequate fit. There was a negative effect of religious fatalism on vaccine acceptance, a positive effect of fatalism on vaccine rejection, a positive effect of concern about new variants on the acceptance of vaccines, and a positive effect of concern about new variants on vaccine rejection.ConclusionThese findings provide evidence for the usefulness of considering both religious fatalism and concern about new variants affect the intention to receive the COVID-19 vaccine in adults in southern Peru.
Heart failure and depression: A perspective from bibliometric analysis
Authors: Lam Mei Ieng , Chen Pan , Xie Xiao-Meng , Lok Grace K. I. , Liu Yu-Fei , Si Tong Leong , Ungvari Gabor S. , Ng Chee H. , Xiang Yu-Tao 
Published: March 2023

BackgroundDepression commonly occurs in heart failure patients, and negatively influences quality of life and disease prognosis. This study explored heart failure and depression-related research from a bibliometric perspective.MethodsRelevant publications were searched on June 24, 2022. The Bibliometrix package in R was used to conduct quantitative analyses including the trends in publications, and related countries, articles, authors and keywords. VOSviewer software was used to conduct the visualization map on co-word, co-author, and institution co-authorship analyses. CiteSpace software was used to illustrate the top keywords with citation burst.ResultsA total of 8,221 publications in the heart failure and depression-related research field were published between 1983 and 2022. In this field, the United States had the most publications (N = 3,013; 36.65%) and highest total citation (N = 149, 376), followed by China, Germany, Italy and Japan. Author Moser and Duke University were the most productive author and institution, respectively. Circulation is the most influential journal. Apart from “heart failure” and “depression,” “quality of life,” “mortality” and “myocardial infarction” were the most frequently used keywords in this research area; whereas more recently, “self care” and “anxiety” have been used more frequently.ConclusionThis bibliometric analysis showed a rapid growth of research related to heart failure and depression from 1989 to 2021, which was mostly led by North America and Europe. Future directions in this research area include issues concerning self-care and anxiety about heart failure. As most of the existing literature were published in English, publications in other languages should be examined in the future.
Effect of fecal microbiota transplantation in children with autism spectrum disorder: A systematic review
Authors: Zhang Jing , Zhu Gang , Wan Lin , Liang Yan , Liu Xinting , Yan Huimin , Zhang Bo , Yang Guang 
Published: March 2023

BackgroundFecal microbiota transplantation (FMT) may be helpful in the treatment of autism spectrum disorder (ASD) as rebalancing the gut microbiome has been shown to potentially improve behavioral symptoms in children with ASD.MethodsThis systematic review was conducted to assess the effect of FMT for children with ASD. The Embase, PubMed, Web of Science, and Cochrane Library databases were searched for articles published from inception to October 6, 2022. Two reviewers independently screened the identified records and undertook data extraction.ResultsThe search identified a total of five studies: two prospective open-label studies, two retrospective observational studies, and a case report; however, no randomized controlled trial was identified. All five studies reported a significant post-FMT-treatment improvement in neuropsychological assessment of ASD. The two prospective open-label studies suggested that the Autism Behavior Checklist (ABC) score, and the Social Responsiveness Scale (SRS) score at the posttreatment assessment decreased from the baseline (Wilcoxon signed-rank test; all p &lt; 0.01]). The two retrospective observational studies suggested that FMT helped to improve the ASD symptoms. One observational study reported that the Childhood Autism Rating Scale (CARS) score and ABC score of the constipation group decreased from the baseline after the second course assessment (CARS [baseline: mean 35.25 ± standard deviation 4.36, second course: 32.5 ± 3.1, p = 0.015]; ABC [baseline: 56.21 ± 16.08, second course: 46.54 ± 16.54, p = 0.046]). Another observational study found that both ABC and CARS scores decreased as the number of FMT courses increased, and significant differences were found at the end of each course as compared with the baseline.ConclusionCompared with the baseline, FMT significantly improved symptoms of autism in children with ASD in observational studies. However, rigorously designed randomized controlled clinical trials are needed to establish the safety and efficacy of FMT as a treatment for ASD.
The burden of hepatitis C virus in the world, China, India, and the United States from 1990 to 2019
Authors: Yang Jia , Qi Jin-Lei , Wang Xiao-Xiao , Li Xiao-He , Jin Rui , Liu Bai-Yi , Liu Hui-Xin , Rao Hui-Ying 
Published: March 2023

Background and aimHepatitis C virus infection can lead to an enormous health burden worldwide. Investigating the changes in HCV-related burden between different countries could provide inferences for disease management. Hence, we aim to explore the temporal tendency of the disease burden associated with HCV infection in China, India, the United States, and the world.MethodsDetailed data on the total burden of disease related to HCV infection were collected from the Global Burden of Disease (GBD) 2019 database. Joinpoint regression models were used to simulate the optimal joinpoints of annual percent changes (APCs). Further analysis of the age composition of each index over time and the relationship between ASRs and the socio-demographic Index (SDI) were explored. Finally, three factors (population growth, population aging, and age-specific changes) were deconstructed for the changes in the number of incidences, deaths, and DALYs.ResultsIt was estimated that 6.2 million new HCV infections, 0.54 million HCV-related deaths, and 15.3 million DALYs worldwide in 2019, with an increase of 25.4, 59.1, and 43.6%, respectively, from 1990, are mainly due to population growth and aging. China experienced a sharp drop in age-standardized rates in 2019, the United States showed an upward trend, and India exhibited a fluctuating tendency in the burden of disease. The incidence was increasing in all locations recently.ConclusionHCV remains a global health concern despite tremendous progress being made. The disease burden in China improved significantly, while the burden in the United States was deteriorating, with new infections increasing recently, suggesting more targeted interventions to be established to realize the 2030 elimination goals.
Exploring the intersection of brain injury and mental health in survivors of intimate partner violence: A scoping review
Authors: Toccalino Danielle , Moore Amy , Cripps Elizabeth , Gutierrez Sophia Chuon , Colantonio Angela , Wickens Christine M. , Chan Vincy , Nalder Emily , Haag Halina (Lin) 
Published: March 2023

RationaleIntimate partner violence (IPV) is the most commonly occurring form of violence against women. The most common site of injury in IPV is the head, face, and neck, resulting in possible brain injury (BI). Independently, mental health (MH) concerns are highly prevalent among both IPV survivors and individuals with BI; however, no systematic review exists on the combined experience of BI and MH in IPV.ObjectiveThe aim of this review was to describe the identification of and relationships between BI, MH, and IPV in the literature and the implications for health policy and practice.MethodsA search strategy including text words and subject headings related to BI, IPV, and MH was developed for MEDLINE and translated to EMBASE, PsycINFO, CINAHL, Cochrane, Scopus, and Web of Science. Two reviewers independently assessed articles for inclusion. Articles discussing MH, BI, and IPV in relation to one another were included in the review.ResultsTwenty-eight articles were identified for inclusion. Methods for identifying IPV, BI, and MH were highly variable across studies. Fourteen studies reported significantly higher MH scores in IPV survivors with BI than in those without BI. Articles predominantly focused on cis gender women in heterosexual relationships and the impact of race and ethnicity were largely overlooked. Healthcare access was explored by eight articles, though none discussed the implications of co-occurring BI and MH.ConclusionBrain injury and MH are highly prevalent among IPV survivors; however, little research discusses the implication for healthcare. Future research should explore healthcare-related needs and experiences to inform policy and practice and better represent the diversity of IPV survivors.