bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis‐Associated Colorectal Cancer
Authors: Sun Ruiqi , Zhang Yuanyuan , Zhao Xian , Tang Tian , Cao Yuepeng , Yang Liu , Tian Yuan , Zhang Zunjian , Zhang Pei , Xu Fengguo 
Published: January 2025

AbstractPatients with ulcerative colitis (UC) have a higher risk of developing colorectal cancer (CRC), however, the metabolic shifts during the UC‐to‐CRC transition remain elusive. In this study, an AOM‐DSS‐induced three‐stage colitis‐associated colorectal cancer (CAC) model is constructed and targeted metabolomics analysis and pathway enrichment are performed, uncovering the metabolic changes in this transition. Spatial metabolic trajectories in the “normal‐to‐normal adjacent tissue (NAT)‐to‐tumor” transition, and temporal metabolic trajectories in the “colitis‐to‐dysplasia‐to‐carcinoma” transition are identified through K‐means clustering of 74 spatially and 77 temporally differential metabolites, respectively. The findings reveal two distinct metabolic profile categories during the inflammation‐to‐cancer progression: those with consistent changes, either increasing (e.g., kynurenic acid, xanthurenic acid) or decreasing (e.g., long‐chain fatty acids, LCFAs), and those enriched at specific disease stages (e.g., serotonin). Further analysis of metabolites with consistent temporal trends identifies eicosapentaenoic acid (EPA) as a key metabolite, potentially exerting anti‐inflammatory and anti‐cancer effects by inhibiting insulin‐like growth factor binding protein 5 (IGFBP5). This study reveals novel metabolic mechanisms underlying the transition from UC to CAC and suggests potential targets to delay the progression.
Nanodrugs Targeting Key Factors of Ferroptosis Regulation for Enhanced Treatment of Osteoarthritis
Authors: Wang Dong , Pan Yanli , Chen Wenzhe , He Du , Qi Weihui , Chen Jiali , Yuan Wenhua , Yang Yimin , Chen Di , Wang Pinger , Jin Hongting 
Published: January 2025

AbstractOsteoarthritis (OA) is a globally prevalent degenerative joint disease. Recent studies highlight the role of ferroptosis in OA progression. Targeting ferroptosis regulation presents a promising therapeutic strategy for OA; however, current research primarily focuses on single targets associated with ferroptosis. In this study, a reactive oxygen species (ROS)‐responsive nanoparticle is developed by linking deferasirox (DEF) and pterostilbene (PTE) with thioketal and incorporating cerium ions (Ce), creating Ce@D&P nanoparticles (NPs), which offer multitarget regulation of ferroptosis. The characteristics of Ce@D&P NPs are evaluated and their therapeutic effects on IL‐1β‐stimulated chondrocytes are verified. Results show that Ce@D&P NPs reduce ROS levels, mitigate inflammation, chelate iron to inhibit ferroptosis, and balance extracellular matrix (ECM) metabolism in chondrocytes. Mechanistically, transcriptomics and metabolomics analyses suggest that Ce@D&P NPs exerted their effects by regulating oxidative stress and lipid metabolism in chondrocytes. To better treat destabilization of the medial meniscus (DMM)‐induced OA in mice, Ce@D&P NPs via intra‐articular injection are delivered. The results show that Ce@D&P NPs alleviate cartilage matrix damage and slow OA progression. Overall, the findings indicate that Ce@D&P NPs represent a promising multitarget drug delivery system, and Ce@D&P NPs may be an effective strategy for OA treatment.
2D Perovskite Heterojunction‐Based Self‐Powered Polarized Photodetectors with Controllable Polarization Ratio Enabled by Ferro‐Pyro‐Phototronic Effect
Authors: Yang Xiaoran , Zhou Binyi , Guo Meitong , Liu Yao , Cong Ridong , Li Leipeng , Wu Wenqiang , Wang Shufang , Guo Linjuan , Pan Caofeng , Yang Zheng 
Published: January 2025

AbstractMetal halide perovskites (MHPs) are commonly used in polarization‐sensitive photodetectors (PDs) for applications such as polarization imaging, remote sensing, and optical communication. Although various methods exist to adjust the polarization‐sensitive photocurrent, a universal and effective approach for continuous control of MHPs’ optoelectronic and polarized properties is lacking. A universal strategy to electrically modulate the polarization ratio (PR) of self‐powered polarized PDs using the ferro‐pyro‐phototronic effect (FPPE) in 2D perovskites is presented. By varying the amplitude and direction of ferroelectric polarization voltage, the built‐in electric field in the heterojunction can be modulated, allowing for controllable PR regulation and adjustable polarization characteristics. Moreover, the polarized pyroelectric photoresponses are realized, significantly enhancing the responsivity, response speed of the polarized PDs. Both the pyroelectric currents and photocurrents exhibit obvious polarization characteristics. This method's versatility is demonstrated by creating three additional quasi‐2D MHP ferroelectric‐based polarized‐sensitive PDs. A proof‐of‐concept for encrypted optical communication is achieved using the UV‐sensitive PDs as light‐sensing units. These findings highlight FPPE's potential to enhance ferroelectric device polarization control, enabling high‐performance and self‐powered polarization photodetection.
Impurity Impacts of Recycling NMC Cathodes
Authors: Meng Zifei , Ma Xiaotu , Hou Jiahui , Zheng Yadong , Wang Yan 
Published: January 2025

AbstractThe skyrocketing demands for electric vehicles cause large quantities of spent lithium‐ion batteries (LIBs) and pressure on the global supply chain, leading to raw materials shortages and cost increases. In LIBs, LiNixMnyCozO2(NMC) cathodes are one of the major cathode materials. Thus, recycling NMC cathodes from spent lithium‐ion batteries is emerging because they contain abundant valuable materials, which can be considered unique “mineral” sources. Impurities are one of the main concerns for introducing recovered materials back into new battery manufacture because impurities are typically considered to impair the properties of recovered materials. However, some impurities can beneficially act as dopants or coatings. To comprehensively understand the effects of different impurities and treat impurities properly, this review summarizes the origin and species of possible impurities which can be introduced during different pretreatment processes, analyzes the methods to remove impurities, and discusses the effects of impurities on the regeneration process and recovered materials. This work also outlines future perspectives for fundamental research about impurities and relevant challenges of the recycling industry, helps academia and manufacturers to create new impurity standards of recovered cathode materials, and suggests opportunities for achieving a circular economy for the lithium‐ion batteries industry.
A Case Study of a Female Infant With Primary Hypertrophic Osteoarthropathy Demonstrates That Early Initiation of Celecoxib Slows but Does Not Prevent Symptom Progression
Authors: Zehr Kara , Buckley Morgan , Owens Joshua W. , Vanagunas Tomas , Fernandez Patricia Vega , Hopkin Robert J. , Shillington Amelle 
Published: January 2025

ABSTRACTPrimary Hypertrophic Osteoarthropathy (PHOAR1) is characterized by autosomal recessive loss of function variants in 15‐hydroxyprostaglandin dehydrogenase (HPGD) leading to digital clubbing, periostosis, pachydermia, and severe hyperhidrosis. HPGD catalyzes the first step of prostaglandin E2 (PGE2) degradation. Selective COX‐2 inhibitors have proved beneficial in adults, though it is unknown if early initiation of COX‐2 inhibitors can alter the natural history of PHOAR1. This individual was diagnosed with PHOAR1 at 3.5 months of age due to homozygous HPGD c.218‐1G>A variants. At presentation, she had a diffuse erythematous rash secondary to hyperhidrosis, mild symmetric clubbing of her fingertips, and mildly decreased mobility of her knees and wrists. By 20 months of age, she had more significant clubbing, mild flexion contractures, joint pain, and fatigue. She started celecoxib at 26 months of age. ResultsAfter 7 months of celecoxib, she had stable digital clubbing, improved hyperhidrosis and contractures, and resolution of her joint pain and fatigue. COX‐2 inhibition appears to be a safe and effective intervention in young children with PHOAR1. More investigation is needed to assess safety and long‐term impact on the natural history of PHOAR1 after COX‐2 inhibition is initiated in early childhood.
Significance of Industry 4.0 in Achieving Sustainable Performance Across Supply Chains—A Research Perspective
Authors: Govardhan Snehal , Narkhede Balkrishna Eknath , Raut Rakesh D. , Zhang Linda L. , Ghoshal Sudishna 
Published: January 2025

ABSTRACTThe enabling technologies in Industry 4.0 (I4.0) are leading to dramatic transformations of supply chains and helping organizations achieve sustainable development goals. With ever‐increasing pressure from regulators and customers to adopt environment‐friendly business practices, achieving sustainable development goals has become critical for any organization. Thus, the seamless deployment of various enabling technologies in I4.0 is vital for managing and enhancing sustainable supply chain performance (SSCP). Adopting enabling technologies across supply chains and their implications on sustainable performance is an emerging area that needs extensive academic research and lasting attention from the practice. This paper examines the adoption of I4.0's digital technologies in the context of SSCP. Bibliometric literature review (SLR) methodology and bibliometric analysis are conducted to analyze the existing literature in SSCP. Moreover, cocitation network analysis and coword analysis are carried out to determine different themes of the literature. Integrating I4.0's enabling technologies is indispensable for enhancing supply chains' social, economic, and environmental performance. The conceptual framework proposed for realizing SSCP based on the I4.0's enabling technologies is a novel contribution. It encompasses competitive advantages, supply chain strategies, and all three aspects of sustainability across a supply chain. This study suggests a framework that contributes to SSCP by adopting I4.0's enabling technologies. Moreover, it identifies a future scope for quantitative research on the contribution of particular I4.0 technologies in dimensions of sustainable supply chains.
Sustainable Equity Index Dynamic: Connectedness and Information Asymmetry in Emerging Markets
Authors: Bhue Rajesh , Gartia Umakanta , Panda Ajaya Kumar , Nanda Swagatika 
Published: January 2025

ABSTRACTThe aim of the study is to investigate the evidence of information asymmetry, dynamic connectedness, and volatility spillover among ESG equity indices of emerging market economies. Using Sign bias test and GARCH family models, the study finds that ESG equity indices have a leverage effect, significantly impacted by bad news over good news shock. The study has used FIGARCH model to measure the persistence of long‐memory effects across the emerging market. Further, to ensure the interconnection between ESG equity indices that may arise due to the persistence of long‐memory effects, the stusy has examined estimates of TVP‐VAR, and finds moderate interconnection between ESG equity indices. To be specific, ESG equity indices of the Philippines, Indonesia, Korea, Singapore, and India are more sensitive to receiving any sustainable innovation shocks from Brazil, South Africa, and Mexican ESG indices. The study finds significant bidirectional relationships between the ESG equity indices of “Philippines and Brazil,” “Indonesia and India,” and “South Africa and Mexico” that may lead to the spreading of market contagion in the presence of more substantial leverage effects with a long memory. This research offers insights for investors to consider sustainable equity assets for efficient portfolio diversification, mitigating environmental, social, and governance risks associated with volatility spillovers and dynamic connectedness. Policymakers may refer the findings of the study to design effective ESG regulations, for reducing risk in global financial system. Since the pandemic has produced more economic and financial instability in emerging markets, investors and regulators may pay more attention to return and volatility connectivity among ESG equity indices and financial markets to safeguard investment and restore market stability.
Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma
Authors: Naganuma Atsushi , Kakizaki Satoru , Hiraoka Atsushi , Tada Toshifumi , Hatanaka Takeshi , Kariyama Kazuya , Tani Joji , Atsukawa Masanori , Takaguchi Koichi , Itobayashi Ei , Fukunishi Shinya , Tsuji Kunihiko , Ishikawa Toru , Tajiri Kazuto , Toyoda Hidenori , Ogawa Chikara , Nishikawa Hiroki , Nishimura Takashi , Kawata Kazuhito , Kosaka Hisashi , Hirooka Masashi , Yata Yutaka , Ohama Hideko , Kuroda Hidekatsu , Matono Tomomitsu , Aoki Tomoko , Kanayama Yuki , Tanaka Kazunari , Tada Fujimasa , Nouso Kazuhiro , Morishita Asahiro , Tsutsui Akemi , Nagano Takuya , Itokawa Norio , Okubo Tomomi , Arai Taeang , Imai Michitaka , Nakamura Shinichiro , Enomoto Hirayuki , Kaibori Masaki , Hiasa Yoichi , Kudo Masatoshi , Kumada Takashi 
Published: January 2025

ABSTRACTAimThis study aims to investigate the clinical utility of the derived neutrophil‐to‐lymphocyte ratio (dNLR) and the Geriatric Nutritional Risk Index (GNRI) in predicting treatment outcomes for patients with unresectable hepatocellular carcinoma (HCC) undergoing combination therapy with atezolizumab and bevacizumab (Atez/Bev).MethodsA retrospective analysis was conducted on 310 patients. The dNLR, NLR, and GNRI were calculated, and their impact on progression‐free survival (PFS) and overall survival (OS) was assessed. The formula for calculating dNLR is: (neutrophil count ÷ [white blood cell count—neutrophil count]), which means it does not require lymphocyte count. Furthermore, GNRI‐dNLR and GNRI‐NLR scores were defined, and their prognostic values were also analyzed.ResultsThe median PFS of this cohort was 7.2 months (95% CI: 5.9–8.5), and the median OS was 24.9 months (95% CI: 19.6–30.2). The dNLR, NLR, and GNRI were significant predictors of both PFS and OS. The dNLR showed a significant correlation with the NLR (Pearson correlation coefficient, p < 0.0001). Patients with high GNRI‐dNLR scores demonstrated significantly worse PFS and OS compared to those with low scores (p = 0.001, p < 0.001, respectively). Compared to stratification by GNRI alone, the GNRI‐dNLR or GNRI‐NLR provided better stratification for both PFS and OS.ConclusionThe dNLR could be a valuable substitute for NLR as a prognostic marker in patients with unresectable HCC undergoing Atez/Bev therapy. It offers a feasible alternative for databases lacking lymphocyte count information, ensuring comprehensive patient stratification and outcome prediction. The GNRI‐NLR or GNRI‐dNLR score provided better stratification compared to GNRI alone.
Impact of smoking status on engagement in remote symptom monitoring after oncologic surgery: Implications for symptom management and readmission rates
Authors: Cracchiolo Jennifer R. , Li Yuelin , Lui Michelle L. , Carlsson Sigrid V. , Matulewicz Richard S. , Ostroff Jamie S. 
Published: January 2025

AbstractBackgroundRemote symptom monitoring (RSM) is an evidence‐based strategy shown to mitigate postoperative morbidity; however, platform engagement is required to benefit from RSM. Patients who report current smoking are at high risk for postoperative complications, but it is unknown whether smoking status influences engagement with RSM, symptom severity, or unanticipated acute care visits.MethodsThis observational case–control study was conducted in patients undergoing ambulatory oncologic surgery at a large cancer center. The authors examined the effect of current smoking status on adherence to an electronically delivered postoperative recovery‐assessment tool. Symptom severity and readmissions by smoking status were also analyzed.ResultsIn total, 19,481 patients who underwent surgery and were enrolled in RSM were included. The nonresponse rate (28%) in current smokers was significantly greater than the rate observed in never smokers (21%; odds ratio, 1.38; 95% confidence interval, 1.17–1.63; p < .0001). Current smokers reported higher symptom scores for pain, wound swelling, constipation, and anxiety. The observed 30‐day readmission rates were 3.6% for current smokers and 2.6% for never smokers, with overlapping confidence intervals.ConclusionsCurrent smokers report higher symptom burden after surgery yet are less likely to adopt proactive digital postoperative recovery strategies like RSM. Implementation strategies are needed to improve the engagement of current smokers in RSM if benefits are to be realized in this high‐risk population.
RF Heating Effects in CEST NMR with Hyperpolarized 129Xe Considering Different Spin Exchange Kinetics and Saturation Schemes
Authors: Hernandez‐Solarte David , Schröder Leif 
Published: January 2025

AbstractChemical exchange saturation transfer (CEST) improves the sensitivity of NMR but depending on the spin exchange kinetics, it can require substantial RF energy deposition to label magnetization. Potential side effects like RF‐induced heating may occur and must be monitored. Here, we explore the parameter space considering not only undesired heating but also efficient CEST build‐up (depolarization rate), spectral resolution (line width), and subsequent effects like changes in chemical shifts of CEST responses. We present a systematic study to compare conventional block pulse with shaped‐pulse saturation and quantify how the effective average saturation power impacts these parameters. Pulse shape and nominal excitation bandwidth, however, turned out to have little impact on acquired z‐spectra and temperature changes. This study illustrates how different exchange kinetics define different regimes of suitable RF power within the dynamic range of fully saturable magnetization from hyperpolarized 129Xe. Temperature‐related changes in the resonance frequency of bound spins were also quantified for the two Xe hosts CB6 and CrA‐ma and put into context for typically used CEST acquisition parameters, including the stability of the magnetic field.
A novel transgenic reporter of extracellular acidification in zebrafish elucidates skeletal muscle T‐tubule pH regulation
Authors: Neitzel Leif R. , Silver Maya , Wasserman Aaron H. , Rea Samantha , Hong Charles C. , Williams Charles H. 
Published: January 2025

AbstractDisruption of extracellular pH and proton‐sensing can profoundly impact cellular and protein functions, leading to developmental defects. To visualize changes in extracellular pH in the developing embryo, we generated a zebrafish transgenic line that ubiquitously expresses the ratiometric pH‐sensitive fluorescent protein pHluorin2, tethered to the extracellular face of the plasma membrane using a glycosylphosphatidylinositol (GPI) anchor. Monitoring of pHluorin2 with ratiometric fluorescence revealed dynamic and discrete domains of extracellular acidification over the first 72 h of embryonic development. These included acidification of the notochord intercalations, transient acidification of the otic placode, and persistent acidification of the extracellular space of the myotome at distinctly different pH from that within the T‐tubules. Knockdown of centronuclear myopathy genes Bin1b (OMIM: 255200) and MTM1 (OMIM: 310400), which disrupt T‐tubule formation, also disrupted myotome acidification. In this study we visualize extracellular acidic microdomains in the tissues of whole live animals. This real‐time reporter line for directly measuring changes in extracellular pH can be used to illuminate the role of extracellular pH in normal physiological development and disease states.
The cochlea phenotypically differs from the vestibule in the Gfi1GFP/GFP mouse
Authors: Li Zhuo , Chen Hongzhi , Feng Hao 
Published: January 2025

AbstractBackgroundPrevious studies with Gfi1‐mutated lines have shown that Gfi1 is essential for hair cell maturation and survival.ResultsWe analyzed the phenotype of another Gfi1‐mutated line Gfi1GFP/GFP in the inner ears of neonates at P5‐7 and found that the cochlea phenotypically differed from the vestibule in the Gfi1GFP/GFP mouse. Specifically, there was a marked reduction in hair cells in the cochlea, which was characterized by greater reductions in the outer hair cells but far less reductions (mainly in the basal turn) in the inner hair cells, whereas the vestibular hair cells remained unaffected. These results were consistent with findings from previous studies. Unexpectedly, the number of cochlear non‐sensory supporting cells significantly decreased. However, the vestibular supporting cells did not demonstrate any abnormalities in number.ConclusionGfi1 exhibits different functions in the cochlea and vestibule during inner ear development.
Assessing the seasonality of foliar nutrient concentrations in woody plants
Authors: Tian Yuehan , Du Enzai , Tang Yang , Peñuelas Josep 
Published: January 2025

AbstractSeasonal variations in foliar nutrient concentrations are an important strategy of plants to adapt to different climates and availabilities of soil nutrients. Gaps in our knowledge, however, remain in both the seasonality of the concentrations of multiple nutrients in plant leaves and their spatial pattern on a large scale. We compiled data on foliar concentrations of nine essential nutrients (N, P, K, Ca, Mg, Fe, Mn, Zn, and Cu) in woody plants in China and evaluated the characteristics and latitudinal patterns of their seasonal variability (i.e., seasonality). Foliar concentrations of mobile nutrients (N, P, K, and Zn) in deciduous broadleaf woody plants decreased significantly during the growing season, but nonmobile nutrients (Ca and Mn) continued to accumulate. In contrast, the foliar nutrient concentrations in evergreen broadleaves and conifers generally showed no significant seasonal trend. The seasonality of foliar nutrient concentration was weaker for the nutrients with higher foliar concentrations, supporting the hypothesis of seasonal stability of high‐demand nutrients. The seasonality of foliar nutrient concentration was stronger for deciduous than evergreen plants, while the effect of plant phylogeny was not statistically significant. The seasonality of foliar N and P concentrations increased with latitude in the deciduous broadleaf woody plants, but evergreen plants showed no significant latitudinal trend. The spatial patterns of seasonality for foliar N and P concentrations were significantly explained by climate and foliar habit. These findings improve our understanding of the seasonality of plant foliar concentrations of multiple nutrients as a strategy to adapt to varying climatic conditions.