bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aksesibilitas Perempuan Disabilitas dalam Pemenuhan Hak Kesehatan Seksual dan Reproduksi
Authors: Pratiwi Martin 
Published: January 2023

ABSTRACT Disability is a condition that causes people with disabilities to be vulnerable to discrimination, harassment, and violence. This includes being vulnerable to violence and sexual harassment. Sexual activity has an impact on a woman's reproductive health. Therefore, it is necessary to have adequate accessibility for women with disabilities to be able to access health facilities and obtain adequate sexual and reproductive health services. This is a disability right. This study aims to see how the condition of accessibility of women with disabilities in fulfilling sexual and reproductive health rights in Indonesia, especially in Bekasi. The method used is a qualitative method with an observation approach so that the data used is primary data. Data analysis was carried out by inductive analysis. The results showed that in Bekasi the provision of access to women with disabilities was quite good, only there was a lack of accommodation. The Bekasi City Government continues to carry out quite a few policies that are responsive to people with disabilities and will continue to be improved. It can be concluded that the accessibility of women with disabilities in fulfilling sexual and reproductive health rights for women with disabilities in Bekasi City is quite good. Keywords: Disability, Health, Sexual, Reproductive, Women ABSTRAK Disabilitas merupakan suatu kondisi yang menyebabkan penyandangnya rawan mendapatkan diskriminasi, pelecehan, dan kekerasan. Termasuk juga rentan mendapatkan kekerasan dan pelecehan seksual. Aktivitas seksual tersebut memiliki dampak terhadap kesehatan reproduksi seorang perempuan. Oleh karena itu, perlu adanya aksesibilitas yang memadai bagi perempuan disabilitas untuk bisa mengakses fasilitas kesehatan dan mendapatkan pelayanan kesehatan seksual dan reproduksi yang memadai. Hal tersebut merupakan salah satu hak disabilitas. Adapun penelitian ini bertujuan untuk melihat mengenai bagaimana kondisi aksesibilitas perempuan disabilitas dalam memenuhi hak kesehatan seksual dan reproduksi di Indonesia khususnya di Bekasi. Metode yang digunakan adalah metode kualitatif dengan pendekatan observasi sehingga data yang digunakan adalah data primer. Analisis data dilakukan dengan analisis induktif. Hasil penelitian menunjukkan bahwa di Bekasi pemberian akses kepada perempuan penyandang disabilitas sudah cukup baik hanya terdapat kekurangan pada akomodasi. Pemerintah Kota Bekasi terus cukup banyak melakukan kebijakan yang responsif penyandang diasbilitas dan akan terus ditingkatkan. Dapat disimpulkan bahwa kondisi aksesibilitas perempuan disabilitas dalam memenuhi hak kesehatan seksual dan reproduksi pada perempuan disabilitas yang ada di Kota Bekasi sudah cukup bagus. Kata Kunci: Disabilitas, Kesehatan, Seksual, Reproduksi, Perempuan
UBERIZAÇÃO E/OU BOLHA DA SERVIDÃO: uma verificação através dos moto-entregadores no espaço metropolitano de Belém-RMB
Authors: Carvalho Raimundo Sócrates de Castro Carvalho Sócrates 
Published: January 2023

UBERIZAÇÃO E/OU BOLHA DA SERVIDÃO: uma verificação através dos moto-entregadores no espaço metropolitano de Belém-RMBResumo: O presente artigo versa sobre o trabalho uberizado, a partir do moto-entregadores de aplicativos no espaço metropolitano de Belém-RMB, tendo por base, as transformações do mundo trabalho, no âmbito da reestruturação produtiva, da flexibilização das leis trabalhistas e a precarização do trabalho, onde buscou-se tecer reflexões, acerca das condições de reprodução social dos trabalhadores uberizados, que buscam alternativas frentes a realidade do desemprego estrutural, imprimido na lógica neoliberal e dos processo de globalização, que exteriorizam a desigualdade e a exclusão social, nos processos espaciais de produção e reprodução do capital.Palavras-chaves: trabalho, uberização, moto-entregadores, restruturação produtiva, precarização
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN MEDIA MONOPOLI TATA SURYA TERHADAP MOTIVASI BELAJAR SISWA DI SEKOLAH DASAR
Authors: Situmorang Tresia , Putra M. Jaya Adi , Witri Gustimal 
Published: January 2023

IPA adalah ilmu pengetahuan yang mendalami mengenai alam semesta beserta isinya, peristiwa yang ada terjadi didalamnya, pembelajaran IPA ini bersifat kompleks dan luas. Oleh karena itu dibutuhkan model pembelajaran yang berbantuan media permainan yang sesuai, menarik dan efektif, sehingga tercapainya tujuan dan motivasi dalam belajar. Model pembelajaran STAD dapat menekankan interaksi antara peserta didik untuk saling memotivasi dan saling membantu menguasai materi yang dipelajari peserta didik. Penelitian bertujuan untuk mengetahui pengaruh model pembelajaran STAD terhadap motivasi belajar siswa di kelas. Penelitian dilakukan secara ofline, adapun jumlah sampel dalam penelitian ini adalah 60 siswa. Kelas kontrol adalah kelas dengan metode ceramah, sedangkan kelas eksperimen adalah kelas yang diberi perlakuan model kooperatif tipe STAD berbantuanmedia monopoli tata surya. Data diperoleh melalui pretest dan posttest. Metode yang digunakan metode eksperimen dengan desain penelitian quasi experimen design dengan rancangan Nonequivalent Control Group Design. Data dianalisis dengan teknik analisis uji hipotesis dan uji t. Hasil menunjukan bahwa uji hipotesis diperoleh hasil signifikan (2-tailed) sebesar 0,000. Maka diliat dari nilai signifikan < 0,05, artinya Ho ditolak dan Ha diterima. Sehingga dapat disimpulkan terdapat pengaruhmodel pembelajaran kooperatif tipe STAD berbantuan media monopoli tata surya terhadap motivasi belajar siswa di kelas VI SDN 35 Pekanbaru.PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN MEDIA MONOPOLI TATA SURYA TERHADAP MOTIVASI BELAJAR SISWA DI SEKOLAH DASAR
PENINGKATAN KOMPETENSI GURU MELALUI PELAKSANAAN KKG (KELOMPOK KERJA GURU) DI SMP NEGERI 6 DUMAI
Authors: Suryani Leni 
Published: January 2023

Penelitian ini dilatarbelakangi oleh rendahnya kompetensi guru di SMP Negeri 6 Dumai. Untuk itu perlu dilakukan suatu tindakan untuk mengatasi masalah tersebut, yaitu melalui Pelaksanaan KKG (Kelompok Kerja Guru). Penelitian ini bertujuan untuk meningkatkan kompetensi guru dalam di SMP Negeri 6 Dumai melalui Kelompok Kerja Guru. Jenis penelitian adalah penelitian tindakan sekolah (PTS) yang bertujuan untuk mengetahui keberhasilan tentang peningkatan kompetensi guru dalam mengajar melalui pelaksanaan KKG (Kelompok Kerja Guru) di SMP Negeri 4 Dumai. Hasil penelitian pada aspek pelaksanaan KKG yang dibawakan oleh tutor diketahui bahwa dari siklus I meningkat pada siklus II. Jika pada siklus I mendapatkan skor sebesar 75% maka pada siklus II sudah lebih baik dengan mendapatkan perolehan skor sebesar 95%. Pada aspek kepeserta didikan didapatkan pada siklus I sebesar 58% dengan kategori cukup baik dan pada siklus II meningkat menjadi 70% dengan kategori baik. Pada aspek evaluasi yang diberikan oleh tutor diketahui bahwa pada siklus I mendapatkan persentase sebesar 60% atau dengan kategori cukup dan pada siklus II meningkat menjadi 76% atau dengan kategori baik. Dari uraian pengolahan data dan pembahasan didapatkan kesimpulan bahwa kompetensi guru dapat ditingkatkan melalui pelaksanaan KKG di SMP Negeri 6 Dumai.
Using magnetic mesoporous silica nanoparticles armed with EpCAM aptamer as an efficient platform for specific delivery of 5-fluorouracil to colorectal cancer cells
Authors: Kamil Mohammad Al-Mosawi Aseel , Bahrami Ahmad Reza , Nekooei Sirous , Saljooghi Amir Sh. , Matin Maryam M. 
Published: January 2023

Background: Theranostic nanoparticles with both imaging and therapeutic capacities are highly promising in successful diagnosis and treatment of advanced cancers.Methods: Here, we developed magnetic mesoporous silica nanoparticles (MSNs) loaded with 5-fluorouracil (5-FU) and surface-decorated with polyethylene glycol (PEG), and epithelial cell adhesion molecule (EpCAM) aptamer (Apt) for controlled release of 5-FU and targeted treatment of colorectal cancer (CRC) both in vitro and in vivo. In this system, Au NPs are conjugated onto the exterior surface of MSNs as a gatekeeper for intelligent release of the anti-cancer drug at acidic conditions.Results: Nanocarriers were prepared with a final size diameter of 78 nm, the surface area and pore size of SPION-MSNs were calculated as 636 m2g−1, and 3 nm based on the BET analysis. The release of 5-FU from nanocarriers was pH-dependent, with an initial rapid release (within 6 h) followed by a sustained release for 96 h at pH 5.4. Tracking the cellular uptake by flow cytometry technique illustrated more efficient and higher uptake of targeted nanocarriers in HT-29 cells compared with non-targeted formula. In vitro results demonstrated that nanocarriers inhibited the growth of cancer cells via apoptosis induction. Furthermore, the targeted NPs could significantly reduce tumor growth in immunocompromised C57BL/6 mice bearing HT-29 tumors, similar to those injected with free 5-FU, while inducing less side effects.Conclusion: These findings suggest that application of Apt-PEG-Au-NPs@5-FU represents a promising theranostic platform for EpCAM-positive CRC cells, although further experiments are required before it can be practiced in the clinic.
Acute infection with Brachyspira hyodysenteriae affects mucin expression, glycosylation, and fecal MUC5AC
Authors: Lin Susanne Je-Han , Helm Emma T. , Gabler Nicholas K. , Burrough Eric R. 
Published: January 2023

IntroductionInfection with strongly β-hemolytic strains of Brachyspira hyodysenteriae leads to swine dysentery (SD), a production-limiting disease that causes mucohemorrhagic diarrhea and typhlocolitis in pigs. This pathogen has strong chemotactic activity toward mucin, and infected pigs often have a disorganized mucus layer and marked de novo expression of MUC5AC, which is not constitutively expressed in the colon. It has been shown that fucose is chemoattractant for B. hyodysenteriae, and a highly fermentable fiber diet can mitigate and delay the onset of SD.MethodsWe used lectins targeting sialic acids in α-2,6 or α-2,3 linkages, N-acetylglucosamine (GlcNAc), α-linked L-fucose, and an immunohistochemical stain targeting N-glycolylneuraminic acid (NeuGc) to investigate the local expression of these mucin glycans in colonic tissues of pigs with acute SD. We used a commercial enzyme-linked immunosorbent assay (ELISA) to quantify fecal MUC5AC in infected pigs and assess its potential as a diagnostic monitoring tool and RNA in situ hybridization to detect IL-17A in the colonic mucosa.ResultsColonic mucin glycosylation during SD has an overall increase in fucose, a spatially different distribution of GlcNAc with more expression within the crypt lumens of the upper colonic mucosa, and decreased expression or a decreased trend of sialic acids in α-2,6 or α-2,3 linkages, and NeuGc compared to the controls. The degree of increased fucosylation was less in the colonic mucosa of pigs with SD and fed the highly fermentable fiber diet. There was a significant increase in MUC5AC in fecal and colonic samples of pigs with SD at the endpoint compared to the controls, but the predictive value for disease progression was limited.DiscussionFucosylation and the impact of dietary fiber may play important roles in the pathogenesis of SD. The lack of predictive value for fecal MUC5AC quantification by ELISA is possibly due to the presence of other non-colonic sources of MUC5AC in the feces. The moderate correlation between IL-17A, neutrophils and MUC5AC confirms its immunoregulatory and mucin stimulatory role. Our study characterizes local alteration of mucin glycosylation in the colonic mucosa of pigs with SD after B. hyodysenteriae infection and may provide insight into host-pathogen interaction.
QT interval dynamics in patients with ST-elevation MI
Authors: Mann Tomer , Moses Amit , Yesaulov Anastasiea , Hochstadt Aviram , Granot Yoav , Rosso Raphael , Shacham Yacov , Chorin Ehud 
Published: January 2023

BackgroundAn association between excessively prolonged QT and ventricular arrhythmia in patients with ST-elevation myocardial infarction has been described; however, the QT dynamics, characterization, and long-term predictive value are not well known.ObjectiveTo characterize QT interval dynamics in patients undergoing ST elevation myocardial infarction (STEMI) and determine its association with mortality.MethodsA retrospective analysis of 4,936 consecutive patients, hospitalized for STEMI between 01/2013–12/2021. Patients with less than three electrocardiograms (ECGs) during index hospitalization were excluded. Baseline demographics, cardiovascular history, clinical risk factors, treatment measures, laboratory results, and mortality data were retrieved from the hospital’s electronic medical records.ResultsWe included 1,054 patients and 5,021 ECGs in our cohort with a median follow-up of 6 years [interquartile range (IQR) 4.3–7.4 years]. The QT was longer in women in comparison to men (428.6 ms ± 33.4 versus 419.8 ms ± 32.52, P-value = 0.001). QT prolongation was greater in females, elderly patients, and patients with STEMI caused by occlusion of the left anterior descending (LAD) coronary artery. We determined QT cutoff to be 445 ms. This value of QT divided our cohort upon arrival into a long QT group (217 patients, 26% of the cohort) and a “normal” QT group (835 patients, 74% of the cohort). The long QT group experienced an increase in combined short and long terms all-cause mortality. The QT upon arrival, on day 2 of hospitalization, and before discharge from the hospital, correlated with long-term mortality.ConclusionQT duration is often prolonged during STEMI; this prolongation is associated with increased mortality and adverse events. Gender is an important mediator of QT dynamics.
Reservoir properties and genesis of tight sandstones—A case study from the Gaotaizi oil layer in the Qijia area, Songliao basin
Authors: Si Shanghua , Zhao Yutao , Er Chuang , Bai Yubin , Wu Weitao , He Junhao 
Published: January 2023

The primary focus of oil and gas exploration for tight sandstone reservoirs is on a quantitative characterization of reservoir properties. This paper uses the tight sandstone reservoir developed in the Gaotaizi oil layer in the Qijia area of the Songliao Basin as an example. The petrology, physical properties, pore–throat characteristics, and the genesis of the densification of the oil-bearing sandstones are elucidated using casting thin-sections, scanning electron microscopy, 3D computerized tomography (CT), and petrophysical experimental techniques. The results show that the Gaotaizi oil layer is mainly composed of clastic rocks and contains small amounts of shell limestone. The clastic rocks are mainly lithic feldspar sandstone and feldspar lithic sandstone, while residual intergranular pores, intergranular dissolved pores, intragranular dissolved pores, intragranular pores and intercrystalline pores constitute the different pore types. Mercury intrusion and 3D computerized tomography analysis showed that micro-nano pores account for 53% of the total pores present. The pore–throat coordination number is distributed between 1 and 4, with an average of 1.8. The pores and throats in the Gaotaizi reservoir have poor connectivity. The porosity distribution of the Gaotaizi oil layer is 1.4%–22.5%, with an average of 9.5%, while the permeability distribution ranges from 0.01 to 27.10 mD, with an average of 0.41 mD. It is an ultra-low porosity and ultra-low permeability tight reservoir. The Gaotaizi oil layer is divided into three types of reservoirs through a systematic study of its pore developmental characteristics. Diagenetic processes like compaction and cementation result in a reduction in porosity and permeability. Compaction, calcite and siliceous cementation, and illite packing are primarily responsible for reservoir densification.
Atmospheric Lamb wave pulse and volcanic explosivity index following the 2022 Hunga Tonga (South Pacific) eruption
Authors: Dalal Prohelika , Kundu Bhaskar , Panda Jagabandhu , Jin Shuanggen 
Published: January 2023

The atmospheric Lamb wave induced by the Hunga Tonga (South Pacific) volcanic eruption on 15 January 2022 was recorded as atmospheric pressure fluctuations at various meteorological stations around the globe, and persisted for several days after the eruption. This Lamb wave had not been reported from any eruption in the last two decades. In the present study, the barometric pressure change induced by the Lamb wave is used as a direct proxy to quantify the volcanic explosivity index (VEI) of this eruption. An empirical equation, which is used as a function of the size of the eruption and the distance of the barometric station from the source of eruption, determined from pressure-change data that the volume of the eruption was ∼8.6 km3. Accordingly, the VEI of the eruption is found to be 5. The VEI derived from the barometric pressure change is consistent with the VEI estimated through seismic waveforms, and hence can be considered a first-order parameter of the eruption.
New geochronological and provenance constraints on the Late Mesozoic sedimentary formations in the western Shandong Province and Tanlu fault zone, China
Authors: Meng Yuanku , Yuan Haoqi , Wang Qingling , Meng Fanxue , Ren Xiang 
Published: January 2023

We present new LA-ICP-MS detrital zircon U-Pb age and trace element data of the Late Mesozoic sedimentary sequences from the western Shandong and Tanlu fault zone, with the aim to constrain the depositional ages and sedimentary sources. The samples from the western Shandong have similar U-Pb age spectra, which can be divided into three major age groups, peaking age at circa 2,475–2,540 Ma, 1820–1870 Ma and 257–285 Ma, with minor Mesoproterozoic, Neoproterozoic and Paleozoic detrital zircon grains. The sample JN recovered from the Tanlu fault zone has an overwhelming majority of the Early Cretaceous detrital zircons with the age peak at circa 125 Ma, whereas the Archean and Paleoproterozoic detrital zircons are subordinate. The weighted average age of the youngest zircons show that the Santai Formation probably had begun deposition at circa 158 Ma and terminated deposition at circa 150 Ma, and the Tianjialou Formation of the Dasheng Group had begun deposition at circa 122 Ma. Our study indicates that the activity of the dinosaurs might occur during the Late Jurassic rather than the Cretaceous in the Shandong province. In addition, most detrital zircons of the studied samples are characterized by the high Th/U ratios and left-inclined REE patterns, revealing a magmatic origin. Morphologically, most detrital zircon grains characterized by angular to sub-rounded shapes indicate a middle-short distance transport from the source regions, whereas minor detrital zircon grains show rounded shapes, indicating a long-distance transport or multiphase recycling. According to detrital age populations in this study, combined with previously published data, we conclude that depositional provenances of the Santai Formation were mainly derived from the western Shandong and Jiao-Liao Belt, and minor detritus were derived from the northern part of the North China Craton and Xing-Meng orogenic belt. The sediments deposited in the Tanlu fault zone were mainly derived from the volcanic and subvolcanic rocks of the Qingshan period in the eastern Shandong, and subordinate depositional sources were from the Jiao-Liao and the basement uplift of the western Shandong, with minor supplier being derived from the Yinshan-Yanshan orogenic belt. The detrital provenance of the Santai Formation indicates that extension of the eastern NCC occurred during the Late Jurassic. The Neoproterozoic detrital zircons play a minor role in the studied strata, indicating that the large sinistral movement of the Tanlu fault zone might have occurred at the Early-Middle Jurassic and formed a paleogeographic separation of the western Shandong and eastern Shandong (Sulu orogenic belt).
Assessing temporal differences of baseline body mass index, waist circumference, and waist-height ratio in predicting future diabetes
Authors: Sheng Guotai , Qiu Jiajun , Kuang Maobin , Peng Nan , Xie Guobo , Chen Yuanqin , Zhang Shuhua , Zou Yang 
Published: January 2023

ObjectiveObesity is the prominent modifiable risk factor known to influence the occurrence and progression of diabetes other than age, and the objective of this study was to evaluate and compare the predictive value of three simple baseline anthropometric indicators of obesity, body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR), for the occurrence of diabetes at different time points in the future.MethodsThe study subjects were 12,823 individuals with normoglycemic at baseline who underwent health screening and had measurements of BMI, WC, and WHtR. The outcome of interest was new-onset diabetes during follow-up. Time-dependent receiver operator characteristics (ROC) curves of baseline BMI, WC, and WHtR for predicting the risk of diabetes in the next 2 to 12 years were constructed and their area under the ROC curves (AUCs) and corresponding optimal threshold values were calculated for each time point, which were used to compare the accuracy and stability of the above three indicators for predicting the occurrence of diabetes in different future periods.ResultsDuring a median follow-up period of 7.02 years, with a maximum follow-up of 13 years, 320 new-onset diabetes were recorded. After adjusting for confounders and comparing standardized hazard ratios (HRs), WC was shown to be the best simple anthropometric indicator of obesity reflecting diabetes risk in all models, followed by WHtR. Time-dependent ROC analysis showed that WC had the highest AUC in predicting the occurrence of diabetes in the short term (2-5 years), and WHtR had the highest AUC in predicting the occurrence of diabetes in the medium to long term (6-12 years), while in any time point, both WC and WHtR had higher AUC than BMI in predicting future diabetes. In addition, we found relatively larger fluctuations in the thresholds of BMI and WC for predicting diabetes over time, while the thresholds of WHtR consistently remained between 0.47-0.50; comparatively speaking, WHtR may have greater application value in predicting future diabetes.ConclusionsOur analysis sustained that central obesity is a more important predictor of diabetes, and in clinical practice, we proposed measuring WHtR as a useful tool for predicting future diabetes.