bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the influence of hydrodynamic cavitation treatment of dark petroleum products on the yield of fractions with boiling points up to 400°C
Authors: Peshnev B. V. , Burlyaeva E. V. , Terenteva V. B. , Nikishin D. V. , Nikolaev A. I. , Andronov K. S. 
Published: January 2023

Objectives. The reduction of the anthropogenic burden on the environment is generally associated with the transition to alternative energy sources. However, some of these have only regional significance, while the effectiveness of others remains doubtful. On this point, innovative processes aimed at increasing the depth of oil refining may be equally important for reducing the carbon footprint. Wave-based technologies such as cavitation may also be included in these processes. Among the various methods for inducing such cavitation phenomena in oil refining, hydrodynamic approaches are especially promising. It has been shown that the treatment effectiveness increases with greater pressure or when augmenting the number of cavitation processing cycles. The aim of this work is to identify the factor (i.e., pressure gradient or number of treatment cycles) having the greatest influence on the change of the characteristics of the oil product.Methods. Cavitation phenomena were created by pumping dark oil products through a diffuser. The pressure gradient ranged from 20 to 50 MPa, while the number of cavitation processing cycles varied from 1 to 10. The influence of cavitation conditions on the change of fractional composition of petroleum products was analyzed. Target fractions are those having a boiling point up to 400°C.Results. It is shown that increased pressure generated in the diffuser leads to a linear increase in the yield of desired cuts. The dependence of the yield of these fractions on the number of processing cycles is described by the growth model with saturation. A proposed equation describes the influence of pressure and number of cycles on the yield of the fractions from initial boiling point temperature (TIBP) to 400°C following cavitation processing of dark oil products. Some of the coefficients of this equation have been associated with the physicochemical characteristics of the feedstock.Conclusions. An equation for predicting the maximum possible yield of the TJBP-400°C fraction as a result of cavitation processing under different conditions of the process is proposed according to the physicochemical characteristics of the feedstock. The prediction error did not exceed 12%. The equation analysis and comparison of energy consumption between different process regimes shows that a higher yield of the target product is achieved by increasing pressure gradient rather than the number of processing cycles.
Features of triamyl citrate synthesis
Authors: Shiryaeva A. D. , Moiseeva S. V. , Levanova S. V. , Glazko I. L. 
Published: January 2023

Objectives. To find an effective way for obtaining triamyl citrate, an environmentally friendly, biodegradable citric acid ester used as a plasticizer for PVC-based polymer compositions.Methods. The possibilities of heterogeneous catalysis were analyzed using the case study of three commercial samples of macroporous sulfocationites (Amberlyst™ 15, Amberlyst™ 70, and TULSION® 66). Homogeneous catalysis was studied using the example of orthophosphoric acid (H3PO4), while self-catalysis was investigated during esterification of citric acid with amyl alcohol (ROH). The syntheses were carried out under identical conditions: T = 110 °C, the ratio of CA:ROH = 1:5 (mol) amount of catalyst 1 wt % on the reaction mass in a thermostatically controlled reactor of ideal mixing with continuous distillation of the resulting water.Results. It was found that in all variants (even under self-catalysis conditions), the conversion of citric acid in 180 min reached 94–99%. Triamyl citrate was formed after 9 h with a yield of 90% only when using a homogeneous catalyst (H3PO4) and in the presence of a heterogeneous catalyst sample (Amberlyst ™ 15).Conclusions. The revealed differences in the reactivity of the studied sulfocationites (Amberlyst™ 15, Amberlyst ™ 70, and TULSION® 66) confirm the well-known theoretical positions, according to which the kinetic pseudo-homogeneous model of the esterification process of hydroxy acids in excess of aliphatic alcohols is based on the law of acting masses and depends on the specific surface area of the catalyst, which for Amberlyst ™ 15 is of the greatest importance as compared to Amberlyst ™ 70 and TULSION® 66 (m2/g): 53:36:35, respectively.
The effect of the causative agent of listeriosis on the body of broiler chickens under experimental conditions
Authors: Borovyk I. V. , Zazharska N. M. , Fotina T. I. 
Published: January 2023

Ross Cobb 500 chickens (40) were divided into four groups of 10 animals. On the 15th day of life, Chickens from experimental groups were orally infected with a daily culture at a dose of 0.5 Mac Farland-1 ml (1.5×108 CFU/cm3) L. innocua, L. ivanovii, L. monocytogenes). One group was a control group. At the time of slaughter, on the 38th day of the chickens' life, blood samples were taken for biochemical and hematological studies. At the end of the experiment, in the control group of chickens, all animals (10) were alive; in the L. innocua, L. ivanovii, and L. monocytogenes groups, 8, 9, and 7 birds remained, respectively. Infection of poultry with the causative agent of listeriosis did not affect the weight of experimental broiler chickens; the average weight of infected animals was almost at the same level as the control group: L. monocytogenes (2278.5 ± 169.6 g), L. ivanovii (2422.8 ± 63.4 g), L. innocua (2358.0 ± 68.9 g), control group (2320.0 ± 70.8 g). Among the biochemical indicators of the blood of broiler chickens, specific biochemical changes were found, which were characterized, first of all, by an increase in the level of creatinine and the ratio of Ca and P and a decrease in the activity of alkaline phosphatase. The established changes may indicate a violation of metabolic processes in bone and muscle tissue due to the action of Listeria. According to the results of hematological studies of the broilers of the control and experimental groups, it was established that heterophilia due to L. monocytogenes, eosinophilia, and lymphocytosis – due to L. ivanovii and L. innocua compared to the control.
Clinical manifestations of taste distortion in highly productive cows
Authors: Sidashova S. O. , Gutyj B. V. , Shnaider V. L. , Honcharenko V. V. , Shcherbatyi A. R. , Stadnytska O. I. , Hulenko M. P. 
Published: January 2023

The results of a comprehensive examination of a group (n = 179) of high-yielding cows of the second half of lactation (more than 200 days) with diagnosed pregnancy (80–225 days of pregnancy) during 30 days of visual observation, among which 6 individuals (3.35 %) were found. symptoms of altaphagia (distortion of taste). Analysis of the biochemical profile of blood serum showed the presence of a number of subclinical abnormalities in a number of indicators, namely (in parentheses are the reference values): Ca/P – 0.92 units (1.1–1.6); total protein – 50.52 g/l (70–85); albumin/globulin – 3.63 units (0.6–1.3); ALT – 35.32 g/l (10–30); AST – 97.32 g/l (10–50); creatinine – 186.10 μmol/l (80–130); alkaline phosphatase – 323.38 units (100–200); urea – 5.08 mmol/l (3.5–6.0). Due to the fact that the active livestock of the dairy complex was provided with fodder base, timely addition of optimized according to modern standards complete mixed diet with 4 % mineral premix, the main causes of biochemical metabolic disorders can be considered dysfunction of intestinal microbiota, digestive and protective functions. of the mucous membrane due to chronic latent inflammatory processes, which was confirmed by the results of the assessment of feed transit (40.09 % of the remains of the daily diet of cows remained after washing of manure samples, which differed in a significant amount of undigested feed components and the inclusion of exfoliated necrotic particles of the mucous membrane). The latent course and accumulation of alimentary pathologies of the digestive tract contributed to the formation of a negative background for the symptoms of endogenous hunger in cows, manifested by signs of altrophagia, which were only clinical and ethological signals of chronic metabolic disorders in many high-yielding lactation groups. Given the importance of maintaining a high physiological status of dairy cows for profitable dairy production, the need to continue research to study the ethological signals of animals remains relevant to find effective means of preventing foodborne illness, including normoflorization of digestive mucosa.
BEDANDENG KUTAI: ORNAMENTASI MELISMATIS DALAM BEDANDENG KUTAI
Authors: Pratama Zamrud Whidas , Setyoko Aris , Purwanti Purwanti 
Published: January 2023

One form of singing or humming that is spread orally is a traditional song or hum that comes from the Kutai tribe called Bedandeng. The purpose of this study was to obtain data on how the history and types contained in the art of Bendadeng. The theory used in this research is historical theory. In addition to the theory about history, the author will also describe the notation of the nyanyain or humming bedandeng. To study it, a qualitative descriptive study was chosen by prioritizing a musicological approach. Data collection is done by (1) literature study, (2) observation, (3) interview, (3) documentation. The stages in analyzing data are (1) data reduction, (2) data presentation, and (3) data analysis (4) conclusion. Clarification of data was again carried out using data triangulation techniques. The results of the study show dandeng or bedandeng is one of the speech arts that exists and develops in Kutai. Bedandeng is a song of lamentation to express what is in the heart. In bedandeng when singing it is not accompanied by any instruments or music and is sung in a recitative way. When viewed from the form of the melody and the lyrics of the bedandeng melody, each melodic phrase has a melismatic ornament. Melismatic ornaments are found at the end of each melodic phrase. It is said to have many melismatic ornaments because in singing Bedandeng, one syllable can be sung with several tones.Kata Kunci: Ornamentasi, Vokal, Bedandeng Kutai.
DISTANCE LEARNING MATHEMATICS USING PQ4R LEARNING STRATEGIES (PREVIEW, QUESTION, READ, REFLECT, RECITE AND REVIEW)
Authors: Sutini Sutini , Sadieda Lisanul Uswah , Ummah Rohmatul , Muryta Azmi Wanda 
Published: January 2023

The Covid-19 pandemic that has hit Indonesia poses a challenge for educators to find effective and efficient alternatives to distance learning. Therefore, this study aims to develop distance math learning devices using the PQ4R (Preview, Question, Read, Reflect, Recite and Review) learning strategies that are valid, practical and effective. This type of research is development research that uses the Plomp development model. This research was conducted at SMPN 1 Duduksampeyan Gresik in the 2021/2022 academic year. The learning devices developed consist of lesson plans and worksheet on the set material.The development phase consists of an initial investigation phase, a design phase, a realization or construction phase and a test, evaluation and revision phase. Data collection methods used are tests, observations and questionnaires. The data were analyzed using the formula for the average value and the percentage was then classified according to the established criteria. The results of data analysis show that distance math learning devices using the PQ4R learning strategies are in the valid, practical and effective categories. This can be seen from the average validity of the lesson plan and student worksheet of 3.78 and 3.87, respectively. While the average practicality of lesson plan and student worksheet are 3.93 and 3.92, respectively. The implementation of the syntax of learning mathematics is included in the very good category with a percentage of 100%. The response of students after participating in the lesson was very positive. Student learning outcomes are included in the very good category with a percentage of completeness of 90.63%.
Pemberdayaan Usaha Mikro Pengrajin Kain Tenun Ulap Doyo di Tenggarong Kabupaten Kutai Kartanegara
Authors: Santoso Eko Budi , Moenek Reydonnyzar , Rahmadanita Annisa , Ramadhani Wahyu 
Published: January 2023

Kecamatan Tenggarong merupakan salah satu Kecamatan yang ada di Kabupaten Kutai Kartanegara
Provinsi Kalimantan Timur yang memiliki khas kerajinan tangan kain tenun Ulap Doyo yang memiliki keindahan sangat khas membuat kain tenun Ulap Doyo banyak dibeli oleh konsumen akan tetapi permintaan para konsumen yang banyak belum dapat terpenuhi oleh para usaha mikro pengrajin kain tenun Ulap Doyo. Hal tersebut membuat Pemerintah Kecamatan Tenggarong terus berusaha mengembangkan potensi di bidang kerajinan melalui Dinas Koperasi dan UKM terutama dalam produksi kain tenun Ulap Doyo untuk memenuhi kebutuhan konsumen. Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis bagaimana pemberdayaan pengrajin kain tenun Ulap Doyo yang dilakukan Dinas Koperasi
dan UKM Kabupaten Kutai Kartanegara dan kendala-kendala dalam pelaksanaannya. Metode yang digunakan yaitu metode kualitatif dengan pendekatan induktif. Teknik mengumpulkan data yang terjadi
di lapangan menggunakan teknik observasi, wawancara, dan dokumentasi . Sebagai pisau analisis, penulis mempedomani pendapat dari Murtyoso (2015). Hasil penelitian menunjukkan bahwa pemberdayaan
usaha mikro pengrajin kain tenun Ulap Doyo yang dilakukan oleh Dinas Koperasi dan UKM belum terlaksana dengan optimal. Hal ini dikarenakan karena ada nya kendala - kendala dalam pelaksanaan pemberdayaan. Berdasarkan hasil penelitian yang menjadi kendala adalah sumber daya manusia terbatas, modal yang
kurang, serta bahan baku yang mulai langka. Dinas Koperasi dan UKM Kabupaten Kutai Kartanegara
melakukan upaya untuk dapat mengoptimalkan pemberdayaan usaha mikro pengrajin kain tenun Ulap
Doyo.
Kata Kunci: Pemberdayaan Usaha Mikro, Kain Tenun, Ulap Doyo
Two-dimensional-Ti3C2 magnetic nanocomposite for targeted cancer chemotherapy
Authors: Darroudi Mahdieh , Elnaz Nazari Seyedeh , Karimzadeh Maryam , Asgharzadeh Fereshteh , Khalili-Tanha Nima , Asghari Seyyedeh Zahra , Ranjbari Sara , Babaei Fatemeh , Rezayi Majid , Khazaei Majid 
Published: January 2023

Introduction: Cervical cancer is the leading cause of cancer-related death in women, so novel therapeutic approaches are needed to improve the effectiveness of current therapies or extend their activity. In recent decades, graphene analogs, such as Mxene, an emerging class of two-dimensional (2D) graphene analogs, have been drawing considerable attention based on their intrinsic physicochemical properties and performance as potential candidates for tumor therapy, particularly for therapeutic purposes. Here we explored the targeted drug delivery in cervical cancer in in vivo model. Mxene-based nanocarriers are not able to be precisely controlled in cancer treatment.Method: To solve this problem, the titanium carbide-magnetic core-shell nanocarrier (Ti3C2-Fe3O4@SiO2-FA) is also developed to provide synergetic anticancer with magnetic controlling ability along with pH-responsive drug release. A xenograft model of the cervix was used to investigate the effects of Cisplatin alone, or in combination with Ti3C2@FA and Ti3C2@ Fe3O4@SiO2-FA, on tumor growth following histological staining for evaluation of necrosis.Result and Discussion: A significant tumor-growth suppression effect is shown when the Ti3C2-Fe3O4@SiO2-FA nanocarrier is magnetically controlled Cisplatin drug release. It reveals a synergistic therapeutic efficacy used in conjunction with pharmaceuticals (p &lt; .001). According to the in vivo study, the Ti3C2@FA@Cisplatin nanocomposite exhibits less tumor growth than the drug alone or Ti3C2@FA@Cisplatin via increasing necrosis effect (p &lt; .001). Through this study, Mxene nanosheets are expanded for biomedical applications, not only through the fabrication of biocompatible magnetic Mxene nanocomposite but also through the development of functionalization strategies that enable the magnetic Ti3C2 nanocomposite to load high levels of Cisplatin for cervical cancer treatment (242.5%). Hence, Ti3C2-Fe3O4@SiO2-FA nanocarriers would be promising candidates to improve cancer treatment efficiency.
Catalytic deAMPylation in AMPylation-inhibitory/assistant forms of FICD protein
Authors: Liu Meili , Li Li , Wang Zhiqin , Wang Shuang , Tang Xiaowen 
Published: January 2023

DeAMPylation, as a reversible reaction of AMPylation and mediated by the endoplasmic reticulum-localized enzyme FICD (filamentation induced by cAMP domain protein, also known as HYPE), is an important process in protein posttranslational modifications (PTMs). Elucidating the function and catalytic details of FICD is of vital importance to provide a comprehensive understanding of protein folding homeostasis. However, the detailed deAMPylation mechanism is still unclear. Furthermore, the role of a conserved glutamine (Glu234), that plays an inhibitory role in the AMPylation response, is still an open question in the deAMPylation process. In the present work, the elaborated deAMPylation mechanisms with AMPylation-inhibitory/assistant forms of FICD (wild type and Glu234Ala mutant) were investigated based on the QM(DFT)/MM MD approach. The results revealed that deAMPylation was triggered by proton transfer from protonated histidine (His363) to AMPylated threonine, instead of a nucleophilic attack of water molecules adding to the phosphorus of AMP. The free energy barrier of deAMPylation in the wild type (∼17.3 kcal/mol) is consistent with that in the Glu234Ala mutant of FICD (∼17.1 kcal/mol), suggesting that the alteration of the Glu234 residue does not affect the deAMPylation reaction and indirectly verifying the inducement of deAMPylation in FICD. In the wild type, the proton in the nucleophilic water molecule is transferred to Glu234, whereas it is delivered to Asp367 through the hydrogen-bond network of coordinated water molecules in the Glu234Ala mutant. The present findings were inspirational for understanding the catalytic and inhibitory mechanisms of FICD-mediated AMP transfer, paving the way for further studies on the physiological role of FICD protein.
Molecular characterization of Arcobacter butzleri isolates from poultry in rural Ghana
Authors: Zautner Andreas E. , Riedel Thomas , Bunk Boyke , Spröer Cathrin , Boahen Kennedy G. , Akenten Charity Wiafe , Dreyer Annika , Färber Jacqueline , Kaasch Achim J. , Overmann Jörg , May Jürgen , Dekker Denise 
Published: January 2023

In recent years, Arcobacter butzleri has gained clinical significance as an emerging diarrheagenic pathogen associated with poultry and water reservoirs. The full clinical significance of Arcobacter remains rather speculative due to variable virulence and antibiotic susceptibility of individual strains. The aims of the present study were (i) to identify antibiotic resistance genes (ARGs) in the genome sequences of two multidrug-resistant A. butzleri isolates, (ii) to use multilocus-sequence typing (MLST) to generate a guiding phylogeny of A. butzleri isolates collected in Kumasi, Ghana, (iii) to examine the distribution of ARGs in the test cohort, and (iv) to assess the strain’s virulence and possible antibiotic treatment options for arcobacteriosis based on the genome sequences and the ARG distribution. A total of 48 A. butzleri isolates obtained from poultry were included in the analysis. These isolates were genotyped by MLST and the antibiotic susceptibilities of isolates to ampicillin, ciprofloxacin, tetracycline, gentamicin, and erythromycin were tested by disk diffusion. Whole genome sequence data of two multidrug-resistant (MDR) A. butzleri isolates were obtained by a combination of single-molecule real-time (SMRT) and Illumina sequencing technology. A total of 14 ARGs were identified in the two generated genome sequences. For all 48 isolates, the frequency of these 14 ARGs was investigated by PCR or amplicon sequencing. With 44 different sequence types found among 48 isolates, strains were phylogenetically heterogeneous. Four of 48 isolates showed an ARG constellation indicating a multidrug-resistant phenotype. The virulence genes in the two A. butzleri genomes showed that the species might be characterized by a somewhat lower virulence as Campylobacter species. The phenotypic susceptibility data combined with the distribution of the particular ARGs especially oxa-464 and the T81I point mutation of the quinolone resistance determining region (QRDR) in a significant percentage of isolates indicated that macrolides and tetracycline can be recommended for calculated antibiotic treatment of arcobacteriosis in Ghana, but not ampicillin and quinolones.
Enhanced myocardial blood flow in ischemic cardiomyopathy by a slow-release synthetic prostacyclin agonist combined with coronary artery bypass grafting: The first human study in a Phase I/IIa clinical trial
Authors: Kawamura Takuji , Yoshioka Daisuke , Kawamura Masashi , Matsuura Ryohei , Kawamura Ai , Misumi Yusuke , Mikami Tsubasa , Sawa Yoshiki , Miyagawa Shigeru 
Published: January 2023

BackgroundYS-1402, which is a polymerized form of the synthetic prostacyclin agonist ONO-1301, has been proven in several preclinical studies to induce therapeutic effects for patients with ischemic cardiomyopathy (ICM). In this human study, we assessed the safety, tolerability, and efficacy of YS-1402, combined with coronary artery bypass grafting (CABG), for ICM.MethodsTwenty-four patients with ICM whose left ventricular ejection fraction was &lt;40% with an indication for CABG were double-blindly assigned to four groups: placebo, 10-mg YS-1402, 30-mg YS-1402, and 100-mg YS-1402. YS-1402 or placebo medications were administered on the surface of the left ventricle at the time of the CABG. Pre- and postoperative cardiac function and myocardial blood flow were assessed for 6 months postoperatively, along with a safety assessment.ResultsNo severe adverse events were related to YS-1402. The maximum blood concentration of ONO-1301 was less than that of the no observable adverse effect level. Significantly increased myocardial blood flow (MBF) and cardiac function were observed in the YS-1402 group 26 weeks postoperatively, although no improvement in MBF occurred in the placebo group.ConclusionThis Phase I/IIa parallel group-controlled, dose-escalation study of YS-1402 combined with CABG for ICM demonstrated the safety, tolerability, and potential efficacy of YS-1402.
Effect of estimated plasma volume status and left atrial diameter on prognosis of patients with acute heart failure
Authors: Chen Xiaomin , Lin Guoli , Dai Caizhi , Xu Kaizu 
Published: January 2023

ObjectiveAcute heart failure (AHF) is a frequent cardiovascular emergency presenting with high mortality as well as readmission rates. The aim was to investigate the predictive value of estimated plasma volume status (ePVs) and left atrial diameter (LAD) for the prognosis of patients with AHF.MethodsClinical profiles were collected from 259 cases of AHF patients at the Affiliated Hospital of Putian University between September 2019 and October 2021.ResultsSix patients lost follow-up, resulting in 253 patients enrolled. Cardiogenic death and heart failure readmission during follow-up were defined as major cardiovascular events (MACE) group, other patients were defined as Non-MACE group. Apart from age, no significant differences were found between the two groups in demographics and comorbidities. The comparison between the two groups was statistically significant in terms of ePVs, LAD, and N-terminal-pro B-type natriuretic peptide (Nt-pro-BNP). On binary logistic regression analysis, ePVs (OR = 2.061, 95% CI 1.322∼3.214, P = 0.001), LAD (OR = 1.054, 95% CI 1.012∼1.098, P = 0.011), and Nt-pro-bnp (OR = 1.006, 95% CI 1.003∼1.010, P = 0.036) as predicting factors for MACE. Kaplan-Meier analysis indicated that the risk for cardiogenic death increasing with ePVs (p &lt; 0.05).ConclusionEstimated plasma volume status and LADs have some predictive value in assessing cardiogenic death and heart failure readmission in patients with AHF.