bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teoría y práctica de la iniciativa legislativa popular en España
Authors: Fernández Silva Ángel 
Published: June 2023

La iniciativa legislativa popular (ILP) en España ha mantenido una eficacia muy limitada con tan sólo cuatro proposiciones adoptadas como ley en el Congreso de los Diputados. Cuarenta años después de la aprobación de la LO 3/1984 de ILP, es preciso analizar las causas que cercenan su empleo, ya que el 37% de las iniciativas resultan inadmitidas y otro 37% caduca sin reunir las firmas requeridas. La Constitución Española estipula (art. 87.3) un margen formal y material muy estrecho para el instrumento, con un requisito de firmas que dificulta el acceso de las propuestas y una exclusión de las materias propias de ley orgánica especialmente lesiva, como se comprobará. Auspiciado por la crisis económica y de confianza, desde el año 2011 se ha producido cierto repunte en la utilización del mecanismo que es preciso analizar, pues parece desmontarse parcialmente la idea extendida sobre el carácter anodino e ineficaz de la figura.
Recibido: 07.02.2023Aceptado: 13.06.2023
ДИНАМИКА ХИМИЧЕСКОГО СОСТАВА ВОД ПОСТПИРОГЕННЫХ БОЛОТ В УСЛОВИЯХ ЛЕСОТУНДРЫ И ТАЙГИ ЗАПАДНОЙ СИБИРИ
Authors: Харанжевская Юлия Александровна , Синюткина Анна Алексеевна 
Published: June 2023

Ссылка для цитирования: Харанжевская Ю.А., Синюткина А.А. Динамика химического состава вод постпирогенных болот в условиях лесотундры и тайги Западной Сибири // Известия Томского политехнического университета. Инжиниринг георесурсов. – 2023. – Т. 334. – № 6. – С.193-203.
Актуальность исследования обусловлена необходимостью оценки изменений химического состава природных вод под влиянием пирогенного фактора. Цель: исследование химического состава вод постпирогенных участков болот в лесотундровой и таежной зонах Западной Сибири, анализ условий его формирования и закономерностей пространственной вариации в зависимости от степени выгорания поверхности. Объекты: Васюганское болото, Усть-Бакчарское болото, плоскобугристое болото у с. Пангоды. Методы. Лабораторное определение химического состава болотных вод проводилось методами титриметрии, спектрофотометрии, пламенной фотометрии в Лабораторно-аналитическом центре Сибирского научно-исследовательского института сельского хозяйства и торфа – филиале Сибирского федерального научного центра агробиотехнологий РАН. Анализ содержания в пробах Cu, Pb, Cd, Zn, P, Mn производился методом масс-спектрометрии с индуктивно-связанной плазмой (ICP-MC) в Химико-аналитическом центре «Плазма». Статистическая обработка данных проводилась с применением непараметрического критерия Уилкоксона, кластерного анализа и метода главных компонент. Результаты. Исследования показали, что индикатором влияния пирогенного фактора на химический состав болотных вод является повышение рН, минерализации и концентраций K+, SO42–, а также Са2+, Mg2+, HCO3–, Feобщ, NO3–, P, Mn, Zn, Cd, Cu, Pb. В процессе восстановления болота после пожара и минерализации верхних выгоревших слоев торфяной залежи в водах отмечается постепенное повышение концентраций NH+4, Сорг и ХПК. Анализ данных по химическому составу показал более высокие – в 4–16 раз – концентрации Са2+, Mg2+, K+, Na+, NH+4, NO3–, Feобщ, HCO3–, Сорг и ХПК, P, Mn, Cu, Zn, Cd, Pb в водах плоскобугристого болота в лесотундре в сравнении с пробами вод, отобранными на выгоревших участках верховых болот таежной зоны Западной Сибири. Факторный анализ показал, что ведущим фактором формирования химического состава вод является степень выгорания поверхности, температура воды и уровни болотных вод. Таким образом, исследования показали, что химический состав вод постпирогенных болот во многом зависит от степени выгорания поверхности, исходных генетических особенностей болота и времени, прошедшего после пожара.
Surgical treatment of patients with mechanical jaundice syndrome caused by choledocholithiasis
Authors: Koryttsev V. K. , Krasnoslobodtsev A. M. , Frolova E. V. , Dergal S. V. 
Published: June 2023

Treatment of patients with mechanical jaundice remains an urgent problem of modern surgery. Approximately in a half of patients the cause of this syndrome is the presence of concrements in the common bile duct. Nowadays there are various variants of choledocholithiasis surgical treatment – open surgery on bile ducts and various variants of endoscopic interventions.Objective: to determine indications for open variants of surgical treatment of the syndrome of mechanical jaundice caused by choledocholithiasis.Material and methods. The work is based on the retrospective analysis of the treatment results of 78 patients with the syndrome of the mechanical jaundice caused by choledocholithiasis. Patients were divided into two groups depending on the way of the mechanical jaundice elimination. The first group included 20 patients who underwent open surgery, and the second group consisted of 58 patients after endoscopic interventions.Results. In the 1st group 4 patients died out of 20 patients, the lethality rate was 20%. In Group II 2 of 58 patients died, the lethality was 3%. The difference in the lethality indexes between the groups turned out to be statistically significant (p = 0,028).Conclusion. Open surgery is indicated in patients with contraindications to pneumoperitoneum application due to the second half of pregnancy or concomitant pathology of the cardiovascular and/or respiratory systems, in unsuccessful attempts to perform endoscopic intervention, and also in concomitant pancreatitis.
Arthroscopic reconstruction of anterior cruciate ligament: study of the correlation between failure rate and the procedure technique
Authors: Shormanov А. M. , Ulyanov V. Yu. 
Published: June 2023

The failure rate in arthroscopic reconstruction of anterior cruciate ligament (ACL) is conditioned by irrational aligning of the drilled transosseous canals, different mechanical properties of the synthetic or auto/allografts, and the number of fixators. By now the published studies on the correlation between failure rate and methods of arthroscopic ACL reconstruction are few. The objective of this research was the investigation of the correlation between the failure rate and certain techniques of arthroscopic ACL reconstruction in patients with its complete isolated rapture.Materials and methods. The study involved 84 patients who in due time underwent single- or double-bundle reconstruction with synthetic implants, or the reconstruction by a semitendinosus and gracilis autografts. The failure rate was estimated in 3, 6, and 12 months by the presence of true clinical signs of the ACL failure along with the patient’s corresponding complaints of the knee joint instability in regular physical load.Results. No differences were observed in the failures rates after surgeries performed by various arthroscopic reconstruction techniques in all periods of observation revealed by the interpretation of true clinical signs of ACL failure and confirmed by the Fisher's exact test value (р > 0.05) and χ2(р > 0.05) for the three groups overall.Conclusion. The examination of patients with complete isolated ACL rapture in all periods of observation for the three samples revealed no correlation between arthroscopic ACL reconstruction failure rates and the employed techniques.
Some aspects of specific prevention of a new coronavirus infection caused by the SARS CoV-2 virus in the Samara region
Authors: Kiryukhin A. I. , Temnik E. I. , Popova L. L. , Konstantinov D. Yu. 
Published: June 2023

The new coronavirus infection remains a significant medical and social event in the world, and only active immunization of the population with the achievement of the target level of vaccination coverage of at least 60% is able to stop its spread.Objective: to study the preliminary results of vaccination against a new coronavirus infection caused by the SARS CoV-2 virus in the Samara region.Materials and methods. The material of this study was the results of statistical monitoring of the incidence of a new coronavirus infection caused by the SARS CoV-2 virus in residents of the Samara region and data on the vaccination campaign. Statistical analysis included descriptive, comparative and interval estimation, as well as correlation analysis.Results. As of October 2022, 62.6% of the total population in the Samara region has been vaccinated against a new coronavirus infection caused by the SARS CoV-2 virus. Women predominated among those vaccinated – 60.51%. When analyzing the results of the vaccination campaign, statistically significant negative relationships were revealed between the proportion of vaccinated in a certain month and the incidence in the next three months, as well as between the accumulated percentage of vaccinated and the incidence in the next few months. At the same time, morbidity and vaccination in a normalized form for the population does not depend on the size of the population.Conclusions: Vaccination reduces the risk of a new coronavirus infection caused by the SARS CoV-2 virus in the Samara region by an average of 7.4 times. With the development of a manifest form of a new coronavirus infection caused by the SARS CoV-2 virus, in residents of the Samara region who have undergone a full course of vaccination, the risk of developing severe and extremely severe forms decreases by an average of 1.65 times, and deaths – by 1.71 times.
DEPENDENCE OF TEMPERATURE DETERMINATION ACCURACY ON THE BANDWIDTH OF THE INTERFERENCE FILTER IN OPTICAL PYROMETRY SYSTEMS
Authors: Voronko Andriy , Novikov Denys 
Published: June 2023

Some general issues common to all reactors for gas-phase epitaxy of A3B5 metal-organic compounds include large temperature gradients in the reactor, leading to the formation of convection loops, high gas flow rates that can result in turbulence instead of the expected laminar flow, and the need for good uniformity and precision in temperature control of the semiconductor substrate surface. Since the deposition process for many complex semiconductor devices (such as infrared laser diodes or heterojunction bipolar transistors) is highly temperature-dependent, a system for precise temperature control of the process at the substrate surface directly in the deposition zone is necessary to obtain high-quality heterostructures with reproducible parameters.
This article describes the features of the epitaxial growth process in MOCVD reactors, as well as highlights the tasks facing the temperature control system. The feasibility of using a radiation compensation system is explored in comparison to measurement methods using a thermocouple and classical pyrometry. Transformation of the input optical signal into a proportional output current in this system is performed by a sensitive photodetector, namely a silicon photodiode. The selection of the wavelength range of the radiation is determined by the optical parameters of the semiconductor substrates and compounds used in the system. The measurement spectrum is determined by the parameters of the interference filter in the system.
The research was conducted to determine the effect of the interference filter width on the accuracy of determining the real temperature of a pyrometric control system with radiation compensation. The dependence of the interference filter characteristic width and shape on the correction value of the temperature of pyrometric systems after calibration is analyzed. Based on the results obtained, recommendations are made for selecting the optimal working wavelength and interference filter bandwidth of the optical system as a compromise between the determination error and the magnitude of the optical signal. The results can be used for the design of modern precision pyrometric systems.
Results of study of quantization and discretization error of digital tachometers with encoder
Authors: Kukharchuk Vasyl , Vasilevskyi Oleksandr , Holodiuk Volodymyr 
Published: June 2023

The analysis of measuring channels of angular velocity with an encoder given by the authors made it possible for the first time to obtain an equation for estimating the quantization and sampling error for an exponential mathematical model describing the transient process of operation of electrical machines. The components of the mathematical model of this dynamic error are the sampling step and the derivative, which characterizes the rate of change of the measured value over time. It was found that the errors of quantization and sampling significantly depend on the value of the resolution z of the encoder. Moreover, an increase in z leads to a decrease in the sampling error, but the relative quantization error increases. To reconcile these components of errors, the laws of change in the distinguishing ability z of the encoder are adaptive to the dynamic properties of the change in angular velocity over time.
Proved that to ensure the maximum speed of measuring the angular velocity during the transient process, it is advisable to implement the method of changing the distinguishing ability of the encoder on the internal timers of the microcontroller proposed adaptive to its dynamic properties, and the quantization of informative periods proportional to the measured angular velocity should be carried out in "adjoining intervals".
SARS-CoV-2 RT-PCR Ct Value and Laboratory Tests
Authors: Legaspi Carolyn Marie , Ong David Jerome , Remulla Jose Iñigo , Agbay Rose Lou Marie 
Published: June 2023

Introduction. The role of the laboratory during the COVID-19 pandemic is not limited to just diagnosis of the disease, but also in clinical decision-making, by providing information on relevant laboratory biomarkers. Clinicians also use Ct value to guide patient management. There are limited studies available locally regarding the significance of Ct value and pertinent laboratory biomarkers in COVID-19 patients. This study aimed to assess the aforementioned laboratory data, along with the clinicopathologic characteristics of affected patients, and determined if this information may be useful for robust clinical decision-making.
Methodology. In this retrospective analytic study, we identified 325 out of 1,049 adult Filipino inpatients diagnosed with COVID-19 and analyzed their Ct values and pertinent laboratory biomarkers such as neutrophil and lymphocyte count, platelet count, LDH, ferritin, procalcitonin, CRP, AST/SGOT, ALT/SGPT, PT/INR, and D-dimer, and correlated them with the severity of the disease.
Results. Two hundred twenty (67.7%) patients had non-severe disease, while 105 (32.3%) had severe disease. Lower Ct values of ORF1ab (median = 26.4) and N (median = 24.8) genes were seen in the severe group compared to the non-severe group and were found to be significant (p<0.001). Laboratory markers (neutrophil, platelet counts, LDH, ferritin, procalcitonin, CRP, AST, PT/INR, and D-dimer) were associated with severe COVID-19. On the other hand, ALT was not associated with severe disease.
Conclusion. The laboratory biomarkers together with Ct value and overall clinical picture may provide valuable information to physicians for more robust clinical decision-making.
Technology Focus: Cementing and Zonal Isolation (May 2023)
Authors: James Simon 
Published: June 2023

In 2022, the topics of the cementing and zonal isolation papers published were generally similar to those presented in previous years. A noticeable departure from previous years, however, was that many of the authors emphasized that their work would result in a reduction of greenhouse-gas emissions. The approaches taken to reduce emissions can be broadly split into three categories: improving operational efficiency, increasing the reliability of zonal isolation (primary cementing, annulus leak repair, and plug sealing), and reducing the CO2 footprint of sealing materials.
Work to improve operational efficiency and increase the reliability of zonal isolation has been ongoing since the start of well construction as general good practice to improve safety and hydrocarbon recovery and reduce costs. The efficiency and reliability improvements, however, have not regularly been promoted as reducing the environmental impact, except for cases of leak repair.
Reduction of the CO2 footprint of sealing materials is a growing source of research and development activity and subsequent publication. During the past year, 13% of the cementing and zonal isolation papers published covered work on the development of geopolymer systems. Although work to develop geopolymer systems for zonal isolation has been ongoing for more than 15 years, no case histories have been published to date. The long development time is not surprising because any new system will have to be at least as reliable as the current Portland-cement-based systems; otherwise, the overall environmental impact may be worse, with more repairs or less-efficient processes offsetting the reduced CO2 footprint of the sealant.
Geopolymers are not the only option to replace Portland-cement-based systems for primary cementing, and the evaluation of alternate sealant systems is certainly not new (see paper SPE-508-G from 1956). Is it time to revisit previous work in light of new environmental constraints?
Recommended additional reading at OnePetro: www.onepetro.org.
IPTC 22019 Enhancing Slurry Pumping Efficiency, Improving Cement Coverage, and Ensuring Zonal Isolation With Temperature-Triggered Antisettling Technology by Xiangyu Liu, ChampionX, et al.
SPE 210639 Thermodynamic Modeling on Wellbore Cement Integrity During Underground Hydrogen Storage in Depleted Gas Reservoirs by Lingping Zeng, Curtin University, et al.
OTC 31562 Cementing the First Australian Offshore Carbon Capture and Storage Appraisal Well by Ariel Lyons, SLB, et al.
Integrative genome-wide gene expression and DNA methylation analysis in brain tissue from medication-free suicide decedents and their controls
Authors: Brundin Lena , Sha Qiong , Fu Zhen , Galvis Martha Escobar , Madaj Zach , Underwood Mark , Steiner Jennifer , Dwork Andrew , Simpson Norman , Galfalvy Hanga , Rosoklija Gorazd , Achtyes Eric , Mann J. John 
Published: June 2023

Abstract
Suicide rates have increased steadily world-wide over the past two decades, constituting a serious public health crisis that creates a significant burden to affected families and the society as a whole. Suicidal behavior involves a multi-factorial etiology, including psychological, social and biological factors. Since the molecular neural mechanisms of suicide remain largely uncharacterized, we examined transcriptional- and methylation profiles of postmortem brain tissue from subjects who died from suicide as well as their neurotypical healthy controls. We analyzed temporal pole tissue from 61 subjects, free from antidepressant and antipsychotic medication, using whole genome RNA-sequencing and DNA-methylation profiling using an array that targets over 850,000 CpG sites. Expression of , a key regulator of inflammation and neuroprotection, was significantly downregulated in the suicide-decedent group. Moreover, we identified a total of 40 differentially methylated regions in the suicide decedent group, mapping to seven genes with inflammatory function. There was a significant association between DNA methylation and expression in the control group that was absent in the suicide decedent group, confirming its dysregulation. expression was significantly associated with the expression of multiple inflammatory factors in the brain tissue. Overall, gene sets and pathways closely linked to inflammation were significantly upregulated, while specific pathways linked to neuronal development were suppressed in the suicide decedent group. Excitotoxicity as well as suppressed oligodendrocyte function were also implicated in the suicide decedents. In summary, we have identified central nervous system inflammatory mechanisms that may be active during suicidal behavior, along with oligodendrocyte dysfunction and altered glutamate neurotransmission. In these processes, NPAS4 might be a master regulator, warranting further studies to validate its role as a potential biomarker or therapeutic target in suicidality.
MultiPrime: A Reliable and Efficient Tool for Targeted Next-Generation Sequencing
Authors: Yang Junbo 
Published: June 2023

Abstract
We present multiPrime, a novel tool that automatically designs minimal primer sets for target next generation sequencing. It enhances coverage by designing primers with mismatch tolerance, ensuring high compatibility and specificity. We compared the performance of multiPrime to that of conventional tools using a dataset of 43,016 sequences from eight viruses. Our results demonstrate that multiPrime outperformed the conventional tools and that the multiPrime-designed primer set successfully amplified the target amplicons. Furthermore, we expanded the application of multiPrime to include thirty viruses and validated the efficacy of multiPrime-designed primers in eighty clinical specimens. The results indicated a sensitivity of 94% and specificity of 89%.
Do dogs display behavioral traits central to Williams-Beuren Syndrome? Transposons, behavior &amp; training success in assistance dogs
Authors: Gnanadesikan Gitanjali E. , Tandon Dhriti , Bray Emily E. , Kennedy Brenda S. , Tennenbaum Stavi , MacLean Evan L. , vonHoldt Bridgett M. 
Published: June 2023

Abstract
Williams-Beuren Syndrome (WBS) is a neurodevelopmental disorder in humans caused by a hemizygous deletion of 28–30 genes and characterized by hypersociability and cognitive deficits. In canines, the homologous chromosomal region shows a strong signature of selection in domestic dogs relative to gray wolves, and four structural variants derived from transposons have been associated with social behavior. To explore these genetic associations in more phenotypic detail—as well as their role in training success—we genotyped 1,001 assistance dogs from Canine Companions for Independence®, including both successful graduates and those released from the training program for behavioral problems. We collected phenotypes on each dog using puppy-raiser questionnaires, trainer questionnaires, and both cognitive and behavioral tests. Using Bayesian mixed models, we found strong associations between genotypes and certain behavioral measures, including separation-related problems, aggression when challenged or corrected, and reactivity to other dogs. Furthermore, we found moderate differences in the genotypes of dogs who graduated versus those who did not; insertions in GTF2I showed the strongest association (β = 0.23, CI95% = -0.04, 0.49), translating to an odds-ratio of 1.25 for one insertion. Our results provide insight into the role of each of these loci in canine sociability and may inform breeding and training practices for working dog organizations. Furthermore, the observed importance of GTF2I supports the emerging consensus that GTF2I genotypes, dosage, and expression are particularly important for the social behavior phenotypes seen in WBS.