bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuneable Gaussian entanglement in levitated nanoparticle arrays
Authors: Chauhan Anil Kumar , Černotík Ondřej , Filip Radim 
Published: December 2022

AbstractOptically levitated nanoparticles emerged as an interesting platform for probing fundamental physics. Quantum control of their motion (including potential shaping) predisposes them for emulating various physical systems and studying quantum phenomena with massive objects. Extending these capabilities to quantum many-body systems requires feasible strategies to couple and entangle nanoparticles directly or via an optical bus. We propose a variable, deterministic scheme to generate Gaussian entanglement in the motional steady state of levitated nanoparticles using coherent scattering. Coupling multiple nanoparticles to a common cavity mode allows cooling of a collective Bogoliubov mode; cooling multiple Bogoliubov modes (by trapping each nanoparticle in multiple tweezers, each scattering into a separate cavity mode) removes most thermal noise, leading to strong entanglement. Numerical simulations for three nanoparticles show great tuneability of entanglement with realistic experimental parameters. Our proposal paves the way towards complex motional quantum states for advanced quantum sensing protocols and many-body quantum simulations.
Targeted degradation via direct 26S proteasome recruitment
Authors: Bashore Charlene , Prakash Sumit , Johnson Matthew C. , Conrad Ryan J. , Kekessie Ivy A. , Scales Suzie J. , Ishisoko Noriko , Kleinheinz Tracy , Liu Peter S. , Popovych Nataliya , Wecksler Aaron T. , Zhou Lijuan , Tam Christine , Zilberleyb Inna , Srinivasan Rajini , Blake Robert A. , Song Aimin , Staben Steven T. , Zhang Yingnan , Arnott David , Fairbrother Wayne J. , Foster Scott A. , Wertz Ingrid E. , Ciferri Claudio , Dueber Erin C. 
Published: December 2022

AbstractEngineered destruction of target proteins by recruitment to the cell’s degradation machinery has emerged as a promising strategy in drug discovery. The majority of molecules that facilitate targeted degradation do so via a select number of ubiquitin ligases, restricting this therapeutic approach to tissue types that express the requisite ligase. Here, we describe a new strategy of targeted protein degradation through direct substrate recruitment to the 26S proteasome. The proteolytic complex is essential and abundantly expressed in all cells; however, proteasomal ligands remain scarce. We identify potent peptidic macrocycles that bind directly to the 26S proteasome subunit PSMD2, with a 2.5-Å-resolution cryo-electron microscopy complex structure revealing a binding site near the 26S pore. Conjugation of this macrocycle to a potent BRD4 ligand enabled generation of chimeric molecules that effectively degrade BRD4 in cells, thus demonstrating that degradation via direct proteasomal recruitment is a viable strategy for targeted protein degradation.
Corn planting and harvest scheduling under storage capacity and growing degree units uncertainty
Authors: Khalilzadeh Zahra , Wang Lizhi 
Published: December 2022

AbstractPlanting and harvest scheduling is a crucial part of crop production due to its significant impact on other factors such as balancing the capacities for harvest, yield potential, sales price, storage, and transportation. Corn planting and harvest scheduling is challenging because corn hybrids have different planting windows, and, subsequently, inaccurate planting and harvest scheduling can result in inconsistent and unpredictable weekly harvest quantities and logistical and productivity issues. In the 2021 Syngenta Crop Challenge, participants were given several large datasets including recorded historical daily growing degree units (GDU) of two sites and provided with planting windows, required GDUs, and harvest quantities of corn hybrids planted in these two sites, and were asked to schedule planting and harvesting dates of corn hybrids under two storage capacity cases so that facilities are not over capacity in harvesting weeks and have consistent weekly harvest quantities. The research problem includes determining the planting and harvest scheduling of corn hybrids under two storage capacity cases: (1) given the maximum storage capacity, and (2) without maximum storage capacity to determine the lowest storage capacity for each site. To help improve corn planting and harvest scheduling, we propose two mixed-integer linear programming (MILP) models and a heuristic algorithm to solve this problem for both storage capacity cases. Daily GDUs are required for planting and harvest scheduling, but they are unknown at the beginning of the growing season. As such, we use recurrent neural networks to predict the weekly GDUs of 70 weeks and consider this as the predicted GDU scenario to solve this problem. In addition, we solve this problem considering all given 10 historical GDU scenarios from 2010 to 2019 together for both storage capacity cases to include historical GDUs directly to our model rather than using predicted GDUs. Our extensive computational experiments and results demonstrate the effectiveness of our proposed methods, which can provide optimal planting and harvest scheduling considering deterministic GDU scenario and uncertainties in historical GDU scenarios for both storage capacity cases to provide consistent weekly harvest quantities that are below the maximum capacity.
Active learning for ordinal classification based on expected cost minimization
Authors: He Deniu 
Published: December 2022

AbstractTo date, a large number of active learning algorithms have been proposed, but active learning methods for ordinal classification are under-researched. For ordinal classification, there is a total ordering among the data classes, and it is natural that the cost of misclassifying an instance as an adjacent class should be lower than that of misclassifying it as a more disparate class. However, existing active learning algorithms typically do not consider the above ordering information in query selection. Thus, most of them do not perform satisfactorily in ordinal classification. This study proposes an active learning method for ordinal classification by considering the ordering information among classes. We design an expected cost minimization criterion that imbues the ordering information. Meanwhile, we incorporate it with an uncertainty sampling criterion to impose the query instance more informative. Furthermore, we introduce a candidate subset selection method based on the k-means algorithm to reduce the computational overhead led by the calculation of expected cost. Extensive experiments on nine public ordinal classification datasets demonstrate that the proposed method outperforms several baseline methods.
Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19
Authors: Blair Paul W. , Brandsma Joost , Chenoweth Josh , Richard Stephanie A. , Epsi Nusrat J. , Mehta Rittal , Striegel Deborah , Clemens Emily G. , Alharthi Sultanah , Lindholm David A. , Maves Ryan C. , Larson Derek T. , Mende Katrin , Colombo Rhonda E. , Ganesan Anuradha , Lalani Tahaniyat , Colombo Christopher J. , Malloy Allison A. , Snow Andrew L. , Schully Kevin L. , Lanteri Charlotte , Simons Mark P. , Dumler John S. , Tribble David , Burgess Timothy , Pollett Simon , Agan Brian K. , Clark Danielle V. ,   the EPICC COVID-19 Cohort Study Group, Cowden J. , Darling M. , Merritt T. , Wellington T. , Rutt A. , Conlon C. , Faestel P. , Mount C. , Smith A. , Tant R. , Warkentien T. , Berjohn C. , Utz G. , Madar C. , Uyehara C. , Chung K. , English C. , Fox C. , Grother M. , Hickey P. , Laing E. , Livezey J. , Parmelee E. , Rozman J. , Sanchez M. , Scher A. , Chao T. , Chapleau R. , Fries A. , Reynolds K. , Hostler D. , Hostler J. , Lago K. , Maldonado C. , Hunter T. , Mody R. , Wayman M. , Huprikar N. 
Published: December 2022

AbstractThe associations between clinical phenotypes of coronavirus disease 2019 (COVID-19) and the host inflammatory response during the transition from peak illness to convalescence are not yet well understood. Blood plasma samples were collected from 129 adult SARS-CoV-2 positive inpatient and outpatient participants between April 2020 and January 2021, in a multi-center prospective cohort study at 8 military hospitals across the United States. Plasma inflammatory protein biomarkers were measured in samples from 15 to 28 days post symptom onset. Topological Data Analysis (TDA) was used to identify patterns of inflammation, and associations with peak severity (outpatient, hospitalized, ICU admission or death), Charlson Comorbidity Index (CCI), and body mass index (BMI) were evaluated using logistic regression. The study population (n = 129, 33.3% female, median 41.3 years of age) included 77 outpatient, 31 inpatient, 16 ICU-level, and 5 fatal cases. Three distinct inflammatory biomarker clusters were identified and were associated with significant differences in peak disease severity (p < 0.001), age (p < 0.001), BMI (p < 0.001), and CCI (p = 0.001). Host-biomarker profiles stratified a heterogeneous population of COVID-19 patients during the transition from peak illness to convalescence, and these distinct inflammatory patterns were associated with comorbid disease and severe illness due to COVID-19.
Molecular of Anaplasma marginale Theiler (Rickettsiales: Anaplasmataceae) in horseflies (Diptera: Tabanidae) in Uruguay
Authors: Rodrigues Gratchela D. , Lucas Martín , Ortiz Hadassa Gabriela , dos Santos Gonçalves Laís , Blodorn Eduardo , Domingues William Borges , Nunes Leandro Silva , Saravia Anderson , Parodi Pablo , Riet-Correa Franklin , Menchaca Alejo , Campos Vinicius Farias , Krolow Tiago Kütter , Krüger Rodrigo Ferreira 
Published: December 2022

AbstractAnaplasma marginaleis transmitted biologically by infected ticks or mechanically by biting flies and contaminated fomites. In tick-free areas, such as southern Uruguay, horseflies could be the principal vectors of this pathogen for bovines, causing anaplasmosis. The objective of this work was to detect the presence ofA. marginaleby MSP-5 PCR and Sanger sequencing in the most prevalent species of horseflies obtained using different collection methods in Colonia, Tacuarembó and Paysandú, Uruguay. Eight horsefly species were tested (Dasybasis missionum,Poeciloderas lindneri, Tabanus campestris,T. claripennis, T. fuscofasciatus, T. platensis,T. tacuaremboensisandT. triangulum); four species were found to be positive forA. marginale, withD. missionumandP. lindnerihaving the most frequent infections, while only one individual each ofT. fuscofasciatusandT. tacuaremboensiswas positive. BothD. missionumandP. lindneriwere positive forA. marginalein tick-free areas, and the implications are discussed in this report.
Analysis of clinical presentations, lip transepidermal water loss and associated dermatological conditions in patients with chronic cheilitis
Authors: Wang Yuanyuan , Lin Liqi , Wang Yuhong , Wei Minghui , Wei Jiao , Cui Yuan , Ren Yanfang , Wang Xinwen 
Published: December 2022

AbstractChronic cheilitis (CC) is a spectrum of inflammatory changes of unknown etiology that affect the vermilion of the lips. This study aimed to describe the epidemiology, clinical presentations and risk factors of CC. Patients with CC were recruited from the National Clinical Research Center for Oral Disease of China. A convenience sample of inhabitants who live in the same geographical region were recruited as the control group. The lip skin transepidermal water loss (TEWL) and capacitance of CC patients were compared with that of age- and gender-matched controls. Our results demonstrated that of the 109 patients with CC, 72 (66.1%; 95% CI: 57.0–75.1%) were female. The common clinical presentations of CC consisted of desquamation (n = 99; 90.8%), and/or chapping (n = 81; 74.3%), and/or pruritus (n = 64; 58.7%). Multivariable analysis showed that allergic dermatologic diseases (P < 0.001; OR: 4.5; 95% CI: 2.4–8.4), anemia (P = 0.001; OR: 3.3; 95% CI: 1.5–7.5), and indoor/outdoor alternate working environment (P < 0.001; OR: 2.1; 95% CI: 1.5–2.8) were the significant risk factors for CC. The mean lip skin TEWL was found to be significantly higher, while the capacitance was lower in CC patients compared to that of control individuals. This study provides insights into the etiopathogenesis of CC and may help clinicians to identify the most effective management strategies.
Observing short-range orientational order in small-molecule liquids
Authors: Gradišek Anton , Apih Tomaž , Beira Maria J. , Cruz Carlos , Fernandes Susete N. , Godinho Helena M. , Sebastião Pedro J. 
Published: December 2022

AbstractLocal molecular ordering in liquids has attracted a lot of interest from researchers investigating crystallization, but is still poorly understood on the molecular scale. Classical nucleation theory (CNT), a macroscopic thermodynamic description of condensation, has shortcomings when dealing with clusters consisting of tens of molecules. Cluster formation and local order fluctuations in liquid media are difficult to study due to the limited spatial resolution of electron- and photon-imaging methods. We used NMR relaxometry to demonstrate the existence of dynamic clusters with short-range orientational order in nominally isotropic liquids consisting of elongated molecules. We observed clusters in liquids where the local ordering is driven by polar, steric, and hydrogen-bond interactions between the molecules. In the case of a liquid crystal, measuring the local orientational order fluctuations allowed us to observe the size of these clusters diverging when approaching the phase transition from the isotropic to the nematic phase. These fluctuations are described in terms of rotational elasticity as a consequence of the correlated reorientations of the neighbouring molecules. Our quantitative observations of the dynamic clusters in liquids, numbering about ten or fewer molecules, indicate that this is a general phenomenon in various types of liquids.
¿Cómo ha afectado el COVID-19 a traumatólogos y residentes de traumatología en Chile?
Authors: Ramírez Constanza , Stefano Pía , Ocampo Juan C. , Yáñez Rodrigo , Gündel Alejandro 
Published: December 2022

Resumen
Introducción Desde marzo del 2020, Chile se ha visto afectado por la pandemia por coronavirus 2019 (coronavirus disease 2019, COVID-19, en inglés), que ha provocado alteraciones en todo el mundo, causando un gran impacto en los servicios de salud y el personal sanitario.
Objetivo Describir características demográficas y laborales relacionadas al contagio de COVID-19 en traumatólogos y residentes de traumatología en Chile.
Métodos Realizamos una encuesta on-line, solicitando información demográfica, datos laborales, exposición y contagio de COVID-19, sintomatología y medidas de protección.
Resultados En total, 567 médicos contestaron. De ellos, 37 (6,4%) tuvieron COVID-19, sin diferencia significativa respecto a género. Se observó mayor contagio entre residentes, 9 de 73 (12,3%), que entre traumatólogos, 28 de 494 (5,7%), así como mayor contagio entre quienes trabajaron más de 60 horas (p <0,05). De los contagiados, 31 (83,8%) eran de la Región Metropolitana (RM), cuyo contagio es significativamente mayor que en el resto de las regiones (p < 0,05). Sólo 8 (21,6%) de los contagiados presentaban antecedentes médicos. Requirieron hospitalización 3 (5,4%), 1 de los cuales en Unidad de Cuidados Intensivos (UCI), y el resto fue manejado en forma domiciliaria. El sitio de contagio más frecuente fue el trabajo, siendo las áreas comunes las más sospechadas, seguidas de la atención ambulatoria y las áreas de hospitalización traumatológica. Un 40.5% (15) reportó haber contagiado a alguien más. Hubo además un impacto en los ingresos de los traumatólogos: un 14,8% (84) refirió una disminución menor al 20%, y un 45%, disminución mayor al 50%. Esta fue mayor en los traumatólogos que en los residentes, y en aquellos de la RM que en otras regiones (p < 0,05).
Conclusión Aunque la actividad traumatológica se ha visto disminuida por la pandemia, los traumatólogos se han visto expuestos al riesgo de contagio por COVID-19. El trabajo parece ser el lugar de mayor riesgo, sobre todo las áreas comunes.
Nivel de Evidencia V.
Locking Compression Plate Fixation of Feline Acetabular Fractures: Application, Complications and Perioperative Outcome
Authors: Murugarren Maider , Piana Francesco , Kalff Stephen , Solano Miguel 
Published: December 2022

AbstractObjectives The aim of this study was to report the use, complications and perioperative outcome of locking compression plates (LCP) for acetabular fracture fixation in feline patients.Study Design Medical records were reviewed for cats presented with acetabular fractures between 2011 and 2019. Only cases that involved open reduction and internal fixation with at least one LCP and had a minimum of 5-week postoperative follow-up were included. Long-term follow-up was based on the Feline Musculoskeletal Pain Index.Results Fifteen cats with 15 acetabular fractures met the inclusion criteria. Locking compression plates were used as a sole method of fixation in 11/15 cases, while with other ancillary implants in 4/15 cases. There were two minor complications related to the LCP consisting of a single screw backing out. Two major perioperative complications not related to the locking implants were described and required further surgical treatment. At the last clinical follow-up (median 46 days: 38–88 days), function was described as full for 7/15 cats, and acceptable for 8/15 cats. The Feline Musculoskeletal Pain Index questionnaire was completed by 9/15 owners at a median of 2,332 days; all owners reported their cats had minimal impairment.Clinical Significance Based on our results, LCP is a suitable implant for acetabular fracture fixation in cats, associated with a satisfactory outcome. Complications were similar to previously reported with other methods.
Chronic insomnia disorder as risk factor for stroke: a systematic review
Authors: Silva Luiz Augusto Soares , Amaral Mateus Molin do , Grassi Vanise , Palmeira André Luiz Rodrigues 
Published: December 2022

Abstract
Background Stroke is one of the main causes of mortality worldwide. Nonetheless, there are still risk factors that have not been fully elucidated, such as chronic insomnia disorder.
Objective To evaluate the association between chronic insomnia disorder and the risk of stroke in adults, through a systematic review.
Methods Multiple studies available in the Embase, Lilacs, and Medline platforms were evaluated in English, Spanish, French, and Portuguese. The selection of papers was restricted to those that had investigated the association between chronic insomnia disorder and stroke in adults, regardless of gender or nationality, without a previous history of stroke. The data was extracted with the Cochrane Effective Practice and Organization of Care (EPOC) form. The risk of bias was evaluated by the EPOC Risk of bias tool.
Results A total of 138 articles were identified. After a detailed evaluation with the eligibility criteria, four articles were included in the present systematic review. Three of them recognized the association between chronic insomnia disorder and stroke. The comparative analysis was limited, since the studies used distinct insomnia classifications. Regarding the risk of bias, the analysis displayed an important risk in the selection and allocation of participants, besides the use of own insomnia diagnosis criteria, disrespecting chronology and factors indicated by already established classifications.
Conclusions There is not enough data to determine that chronic insomnia disorder is a risk factor for stroke. The present study points out the existence of a possible relationship between insomnia disorder and stroke, suggesting that further studies adopt standardized criteria and instruments.
Stroke-related mortality analysis in Paraná, Brazil, over 10 years
Authors: Ducci Renata Dal-Prá , Tessaro Camila Lorenzini , Fontes Daniela Piera , Fraga Gabriel Schier de , Cirino Raphael Henrique Déa , Neto Francisco Diego Negrão Lopes , Zetola Viviane de Hiroki Flumignan , Lange Marcos Christiano 
Published: December 2022

Abstract
Background Stroke is the second leading cause of death and disability around the world.
Objective The purpose of this study is to evaluate the age- and sex-specific mortality rates related to stroke in the state of Paraná, Brazil, between 2007 and 2016.
Methods In this cross-sectional study, residents in the state of Paraná were selected by death certificates (from 2007–2016); the basic cause of death was stroke. A descriptive analysis was performed, and mortality rates were calculated with a 95% confidence interval (95% CI) for each year.
Results From 2007 to 2016, there were 62,607 deaths in the state of Paraná due to stroke. Most individuals had medical assistance before death (85.7% in 2007 versus 83.9% in 2016), and most of these deaths occurred in hospitals (73.6% in 2007 versus 74.8% in 2016). Death rates due to stroke increased from 138 (95% CI 135–142) to 163 (95% CI 159–166) per 100,000 inhabitants. This raise occurred mainly in those over 79 years old. For the ages groups of 34 to 44 and 44 to 54 years, mortality rate decreased.
Conclusions In the past 15 years, despite the advances in the diagnosis and treatment of stroke, there has been an increase in mortality due to stroke in the state of Paraná. This fact is possibly associated with the aging of the population because there was a more pronounced increase in the group over 79 years old. Thus, new health strategies are necessary to improve the survival and quality of life of poststroke individuals.
Knowledge and emotional attitudes of health care practitioners regarding patients with psychogenic nonepileptic seizures
Authors: Saker Thani Sheikh , Katson Mark , Herskovitz Sari Eran , Herskovitz Moshe 
Published: December 2022

Abstract
Background Psychogenic nonepileptic seizures (PNESs) are paroxysmal events that resemble epileptic seizures without concomitant changes in electroencephalograms (EEGs) or any other physiological cause. These seizures are one of the most common and dramatic conversion disorders. First responders treat many PNES patients with unnecessary emergency abortive medication and sometimes even intubate them. Several of our PNES patients have complained they have experienced harsh attitudes from health care practitioners (HCPs), especially during their stay in the emergency room (ER).
Objective To assess the emotional attitude of HCPs toward PNES patients.
Methods We handed a questionnaire containing 23 questions regarding PNES patients to HCPs from emergency medicine, internal medicine, and neurology disciplines. The questions dealt with three categories: diagnosis, management, and emotional attitudes.
Results Overall, 47 HCPs participated in this study: 11 ER, 18 internal medicine, and 18 neurology practitioners. The HCP from those disciplines showed high knowledge and good management practice of PNES patients. On the other hand, the HCPs agreed with most emotional attitude statements regarding PNES patients, reflecting a high percentage of negative emotional attitudes toward this group of patients. We did not find any correlation between negative emotional attitude and HCP department, profession, or seniority.
Conclusions Although HCPs in our center perform good management practice regarding PNES patients, most reported a negative emotional attitude. This finding implies that what PNES patients feel regarding the harsh attitudes is also reflected by HCP views. Emotional attitudes towards PNES patients may not depend solely on the level of knowledge of the HCPs.