bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Emergency Warning Nursing on CRP, PCT, TNF-α and Clinical Indicators in Patients with Acute Stress Disorder under Hierarchical Analysis
Authors: Shao Yanxia , Zhou Xiaoping , Liu Han , Li Tianjiao , Wang Yushu , Chen Ya , Huang Xiangcheng , Sun Wei 
Published: January 2025

Background: In emergency warning nursing, the pre-alert system significantly influences the biochemical markers and clinical outcomes of patients with Acute Stress Disorder. Therefore, this study applies hierarchical analysis to explore the impact of early warning nursing on crucial indicators such as C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and assess their clinical efficacy.
Methods: The study selected patients with acute stress disorder who were hospitalized in Southwest Hospital of Chongqing from December 2021 to December 2022, and collected data from 250 patients. Through PSM score matching, 170 patients were finally scored and grouped, 85 patients in each group, which were divided into routine group and stratified analysis group. The changes in serum inflammatory markers, psychological resilience, and post-traumatic growth were compared between the two experimental groups on day 1 of admission and after 14 days of intervention.
Result: After one day of admission, there was no significant difference in the serum factor levels, psychological resilience, and post-traumatic growth among the participants (p > 0.05). However, after 14 days of intervention, patients in the hierarchical analysis group showed better outcomes in serum inflammatory markers such as C-reactive protein, procalcitonin, tumor necrosis factor-alpha, and interleukin-6 compared to the conventional group (p < 0.05). The hierarchical analysis group had higher psychological resilience scores regarding strength, optimism, and resilience compared to the conventional group (p < 0.05). Furthermore, the hierarchical analysis group showed higher post-traumatic growth scores regarding mental changes, personal strength, appreciation of life, interpersonal relationship, and new possibilities relative to the conventional group (p < 0.05).
Conclusion: Analytic Hierarchy Process (AHP)-based emergency warning nursing can help improve the serum inflammatory factor levels, strengthen psychological resilience, and enhance post-traumatic growth levels in patients with Acute Stress Disorder.
Mobile Health for Obsessive-Compulsive Disorder: Patients' Preferences and Perception of Patient-Centeredness
Authors: Araújo Ana Isabel , Pereira Ana Telma , Duarte Isabel Catarina , Cardoso Remy , Castelo-Branco Miguel , Macedo António 
Published: January 2025

Background: The increasingly fast development of mobile health technologies holds significant value for individuals dealing with mental health conditions. However, inadequate consideration of patients' preferences and expectations undermines real-world outcomes, including sustained adherence. Driven by the belief that specific characteristics, such as youth and higher education, of individuals with obsessive-compulsive disorder make them suitable for digital adoption, we investigated mHealth-related desirability factors within this patient group.
Methods: Fifty-one conveniently selected adults with obsessive-compulsive disorder filled in a self-report questionnaire about symptom self-management preferences, with an emphasis on assessing mobile health options and perceptions of patient-centeredness.
Results: The smartphone phone app emerged as the top choice of most of the sample for receiving information about symptom status (82.4%), obtaining general information about obsessive-compulsive disorder (74.5%), and symptom self-registration (66.7%), with no significant effect of sex or living location. Although only 23.5% of participants were using a health-related app, most expressed interest in using it for receiving symptom management tips (98.1%), medical advice (94.2%), symptom evolution updates (90.2%), lifestyle information (92.2%), medication tracking (88.2%) and short symptom self-reports (90.2%). Median expectations regarding mobile health's impact on patient-centeredness, satisfaction, and adherence were positive or very positive.
Conclusions: Our data confirm that individuals with obsessive-compulsive disorder exhibit strong inclinations and optimistic expectations toward technology-based solutions. We highlight some of the preferences within this patient group, which can inform the design of practical, real-world applications.
Ginsenoside Rg1 Promotes the Survival, Proliferation, and Differentiation of Senescent Neural Stem Cells Induced by D-galactose
Authors: Sun Peiyu , Wang Shunhe , Hu Ling , Huang Yinhu , Wang Yaping 
Published: January 2025

Background: Neural stem cells (NSCs) disrupt with aging, contributing to neurodegeneration. Ginsenoside Rg1 (Rg1), a compound found in Ginseng, is known for its anti-aging effects; however, its role in the progression of aging NSCs remains unclear. Therefore, this investigation explored the impact of Rg1 on the growth and maturation of aging NSC and elucidated its underlying molecular mechanisms.
Methods: Initially, mouse models of brain aging were successfully established using D-galactose (D-gal) injection. Mice received Rg1 treatment along with D-gal administration. Brain tissues and NSCs were isolated and analyzed for pathological changes, gene expression, and cellular function. In vitro, experiments used aging NSCs treated with Rg1 to assess cell viability, proliferation, differentiation, and senescence markers.
Results: D-gal triggered aging-related pathological alterations in mouse brains, elevated acetylcholinesterase levels, upregulated senescence genes, and inhibited NSC proliferation (p < 0.05). However, Rg1 treatment mitigated D-gal-induced effects, delayed brain aging, and improved NSC function. In vitro, Rg1 significantly increased cell viability, promoted NSC proliferation and differentiation, reduced senescent neurons, and downregulated p53 and p21 genes (p < 0.05).
Conclusions: Rg1 demonstrates anti-aging properties in D-gal-induced mouse brain aging, promoting the proliferation and differentiation of NSCs, and downregulating the p53-p21 signaling pathway.
Current Status of Depression in Patients with Endometriosis and Rheumatoid Arthritis
Authors: Wen Shuting , Zhang Aiping , Shi Xin , Hu Junping , Ma Xiaoling , Peng Cheng , Liu Lin , He Rongxia 
Published: January 2025

Background: Endometriosis often causes chronic pain and fertility issues, exacerbating the risk of depression and complicating conditions like rheumatoid arthritis, which further impacts quality of life. This study aimed to explore the detection rate of depression in patients with endometriosis and rheumatoid arthritis by using different diagnostic criteria, and to analyze the occurrence and influencing factors.
Method: A total of 108 patients with endometriosis combined with rheumatoid arthritis in the First Hospital of Lanzhou University from July 2021 to July 2023 were selected as samples. The internationally accepted Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), the new depression assessment tool Hamilton Depression Scale (HAMD), and the Self-rating Depression Scale (SDS) were used to detect the incidence of depression in patients with endometriosis and rheumatoid arthritis. On the basis of the DSM-5 results, patients with concurrent depression were categorized into the observation group, and those without depression were categorized into the control group. The patients' clinical data were collected, and the impact factors were analyzed through binary logistic regression.
Results: DSM-5 detected 20 patients with depression, with a detection rate of 18.52%. HAMD detected 21 patients with depression, with a detection rate of 19.44%. SDS detected 18 patients with depression, with a detection rate of 16.67%. The difference in the detection rate of depression in patients with endometriosis combined with rheumatoid arthritis among the three methods was not statistically significant (p = 0.865). Binary logistic regression analysis showed that dysmenorrhea (odds ratio (OR) = 3.589, p = 0.005), dyspareunia (OR = 2.964, p = 0.012), Visual Analog Scale score (OR = 2.545, p = 0.001), Disease Activity Score-28 score (OR = 3.828, p = 0.004), Pittsburgh Sleep Quality Index score (OR = 3.942, p = 0.004), and Health Assessment Questionnaire-Disability Index score (OR = 3.527, p = 0.008) were significant influencing factors for depression.
Conclusion: DSM-5, HAMD, and SDS can be used to detect depression in patients with endometriosis and rheumatoid arthritis as effective tools for depression screening. Dysmenorrhea, dyspareunia, Visual Analog Scale (VAS), Rheumatoid arthritis disease activity (DAS28), Pittsburgh Sleep Quality Index (PSQI), and Health Assessment Questionnaire-Disability Index (HAQ-DI) are influencing factors of depression in these patients.
مقایسه‌ی حرکت اهتزازی غیرهارمونیکی رقاصه‌ی ساده در بررسی تیوریکی و تجربوی
Authors: خاوری رجب علی 
Published: January 2025

در این مقاله با استفاده از دیتای تجربوی بدست آمده در لابراتوار فزیک، نتایج تیوریکی چند نویسنده در انکشاف میتودهای مختلف برای دریافت فرمول ساده برای پریود اهتزاز رقاصه‌ی ساده مورد ارزیابی قرار گرفته و تطابق دو فرمول با نتایج تجربی به‌خوبی مشاهده گردید. عملکرد دیتاگیری براساس دقت سنسور نوری و زاویه‌سنج تا 1% خطا به‌دست آمده است. نتایج تیوریک براساس یک سلسله ساده‌سازی‌ها به‌دست آمده است که در انتروال‌های معینی برقرار است و نتایج تجربی میزان دقت و انتروال کاربرد فرمول را تعیین می‌کند. انتروال اندازگیری زاویه 0-80 درجه می‌باشد که در این انتروال رقاصه یک حرکت دایروی را دارد. در بررسی نتایج عملی با تیوری ملاحظه می‌گردد که تقریب‌های و نسبت به دیگر تقریب‌ها تطابقت بیشتری دارد و می‌تواند منحیث یک فرمول پریود اهتزازات رقاصه‌ی ساده در زوایای بزرگ پذیرفته شود.
مطالعه اشتباهات دوایی در جریان پروسه‌ی استفاده‌ی ادویه
Authors: نظری قندآغا 
Published: January 2025

اشتباهات دوایی یک نگرانی عمده در جهان و به‌خصوص افغانستان بوده که می‌تواند باعث عواقب کلینیکی و اقتصادی جدی به مریضان شود. هدف از این مقاله، مروری بر اشتباهات دوایی در جریان پروسه‌ی استفاده‌ی ادویه در نزد مریضان بوده که از مقالات ژورنال‌های معتبر علمی استفاده شده است. شیوع اشتباهات دوایی در جریان تجویز، رونویسی، توزیع، تطبیق و نظارت دوایی در نزد مریضان نظر به مقالات مختلف متفاوت بوده و یک افزایش قابل ملاحظه را نشان می‌دهد. اشتباهات دوایی انواع مختلف داشته که در جریان پروسه‌ی استفاده‌ی دوا به‌شمول تجویز ادویه توسط طبیب، توزیع ادویه توسط فارمسیست و تطبیق ادویه توسط نرس واقع می‌شود. عوامل مختلف در وقوع اشتباهات دوایی دخیل بوده که عمدتاً شامل عوامل ناشی از تجویز، توزیع، تطبیق و نظارت دوایی می‌باشند. بنابرآن، نیاز است تا در هنگام استفاده‌ی دوا در نزد مریضان دقت و احتیاط بیشتر صورت گیرد تا از اشتباهات دوایی و عواقب ناشی از آن جلوگیری به عمل آید.
د ریټسکرین سافتویر په واسطه د غور ولایت پوزلیچ کوچني اوبیز برښنا کوټ پروژې د امکاناتو د تحلیل بیا ارزونه
Authors: مجیب مجیب‌الله , احمدزی مجیب الرحمن , میرزازاده عین الله 
Published: January 2025

کوچني اوبیز برښنا کوټونه د نوي کیدو وړ انرژي له سرچینو څخه دي ځکه چې د اوبو څخه په آسانه توګه انرژي تولیدیږی او د چاپیریال لپاره د انرژی بې ضرره سرچینه ده. د ریټسکرین (RET Screen) په نوم یو کمپیوټري سافټویر د کوچنیو اوبیزو برښنا کوټ پروژو ارزونې لپاره یو ډیر ښه میتود ده. د ریټسکرین سافټویر پواسطه د پروژې لومړني لګښتونه، انرژي تولید، عملیاتي او مراقبتي لګښتونه، اقتصادي او مالي تحلیل او حساسیت تحلیل په ډیر کم وخت کې ترسره کیدای شي. د مطالعې لپاره مو د غور پوزلیچ برښنا کوټ پروژه ټاکلې ده، کوم لپاره چې امکان سنجي مطالعات یي په (۲۰۰۷) م کال کې ترسره شوی ده، نو د غور پروژې امکان سنجي مطالعات مو په ریټسکرین سافټویر کې ارزولي او لاسته راغلې پایلې یې د امکان سنجي مطالعې سره پرتله شوي دي، چې باالاخره ښې پایلې په لاس راغلی دي.
بررسی مقایسه‌یی عوامل زمینه‌ساز برای تولید افلاتوکسین‌ها
Authors: علی زاده محمدنعیم 
Published: January 2025

افلاتوکسین­ها متابولیت­های ثانویه­‌یی هستند که توسط آسپرجیلوس فلاووس و آسپرجیلوس پارازیتیکوس تولید می­شوند. که تحت شرایط مساعد؛ مانند حرارت، رطوبت، pH و رطوبت نسبی می­توانند مواد غذایی انسان­ها و مواد خوراکی حیوانات را قبل و بعد از برداشت آلوده‌کنند. از 20 افلاتوکسین شناسایی شده 6 نوع آن B1)، B2،G1 ، G2،M1 و(M2 بسیار مهم می­باشد. اما افلاتوکسین B1 به‌خاطر ارتباط مستقیم با سرطان جگر انسان­ها مضرترین شکل آن­ها است. واقعات آلودگی افلاتوکسین در جواری، گندم، برنج و جوار سبز بسیار شایع است. در این مقاله نویسنده تلاش نموده تا عوامل زمینه‌ساز برای تولید افلاتوکسین را که شامل عوامل فزیکی، تغذیه­وی و بیولوژیکی می­باشد، مورد بحث و بررسی قرار دهد.
تحقیق تجربی درباره قضیه محورهای غیرعمود در تعیین مومنت عطالت اجسام سخت با استفاده از رقاصه فزیکی
Authors: خاوری رجب علی 
Published: January 2025

در محاسبه مومنت عطالت، قضیه محورهای عمود برای اجسام یک بعدی و دوبعدی برقرار است. این قضیه از ابزارهای مفید برای محاسبه مومنت عطالت اجسام میباشد. این قضیه در باره سه محور عمود برهم نیز برقرار میباشد. تحقیق تجربی برای صحت ان در حالتهای غیر عمود صورت گرفته و تجارب روی میله های باریک غیر عمود برهم انجام شده است. نتیجه بدست امده نشان میدهد این قضیه در حالتهای غیر عمود نیز برقرار میباشد. رقاصه فزیکی برای تحقیق تجربی پریود اهتزاز بکار گرفته شده و همچنین تیوریهای لازم برای محاسبه تیوریک فراهم گردیده است که نتیجه ان دریافت قیمتها و گراف با خطای تقریبی کمتر از 1%‌ در تمامی مراحل تجربه و نتیجه گیری میباشد. نتایج به دو صورت تحلیل ارقامی و تحلیل گرافیکی ارزیابی شده است، که در هردو مرحله تفاوت بدست امده از خطای نسبی تجربه کمتر میباشد.
Discriminação por rixa, acompanhada de assédio moral
Authors: Furtado Emmanuel Teófilo 
Published: January 2025

Trata do assédio moral a partir do conceito da médica do trabalho Margarida Barreto que afirma ser tratar de atos perversos praticados por superiores hierárquicos contra seus subordinados. Aponta que são condutas abusivas, que visam demarcar o espaço do poder: quem manda e quem obedece e o agressor não dá trégua àquela pessoa que deve ser eliminada da empresa. Lembra que é manifestada por meio de gestos, palavras, ironias, desqualificações, ridicularizações, palavras ofensivas e ameaçadoras que atingem a dignidade, identidade e saúde dos trabalhadores, degradando as condições de trabalho e as relações interpessoais; colocando em risco a vida e a permanência no emprego. Finaliza dizendo que em termos de legislação muito se tem ainda em sede de projetos, quer na esfera municipal, estadual e federal. Boa parte prevê a consideração da prática do assédio moral como crime.
O enunciado n° 363 do TST e a necessidade urgente do seu cancelamento: uma abordagem crítica das demandas trabalhistas envolvendo a contratação de pessoal, sem concurso, no âmbito da administração pública
Authors: Reis Sérgio Cabral dos 
Published: January 2025

O presente artigo pretende demonstrar e rebater os argumentos normalmente trazidos aos processos judiciais trabalhistas pela administração pública, quando se trata de um caso de contratação de pessoal sem o cumprimento da constitucionalmente exigível prestação prévia de concurso público. Na verdade, o artigo é uma crítica ferrenha à jurisprudência majoritária do C. TST acerca da temática, manifestada através do malsinado enunciado 363. Pretende-se demonstrar que o contrato de emprego, na sua visão estrutural, possui três planos distintos: o da existência, o da validade e o da eficácia. Nesse contexto, afirma-se que tais planos podem conviver harmonicamente no ordenamento jurídico. Dessa conclusão, outras se impõe no sentido de que, através de uma interpretação crítica e sistemática das normas constitucionais aplicáveis, o caso em epígrafe enseja uma situação de contrato existente e inválido, mas eficaz, justamente para a preservação dos princípios da promoção da dignidade da pessoa humana do trabalhador e da valorização social do trabalho, relegando-se, deste modo, a formalidade a um plano secundário.
Execução de contribuições previdenciárias pela Justiça do Trabalho
Authors: Lima Rinaldo Costa 
Published: January 2025

Trata de matéria muito discutida, atualmente, e que tem sido a outorga constitucional concedida à Justiça do Trabalho para executar as contribuições previdenciárias. Neste trabalho serão somente discutidos os problemas relacionados com a Previdência Social e mais particularmente com a execução de suas contribuições pela Justiça do Trabalho. Conclui que com a nova decisão do Pleno do Colendo TST, não cabe mais discussão sobre a matéria, salvo norma votada pelo Poder Legislativo, dispondo sobre o assunto. Como a contribuição deve ser recolhida diretamente na conta do trabalhador, é imprescindível que seja vinculada aos direitos previdenciários, inclusive aposentadoria, pois, atualmente, segundo notícias do Colendo TST, os valores correspondentes têm sido carreados para um fundo específico do INSS.

O Capítulo que trata da matéria, na Constituição vigente, recebeu a denominação de DA SEGURIDADE SOCIAL, que compreende outras ações, como já foi dito.
Responsabilidade civil do empregador nos acidentes laborais
Authors: Barbosa Amanda 
Published: January 2025

Trata do art. 7°, inciso XXVIII, da Constituição Federal que prevê como direito dos trabalhadores urbanos e rurais, além de outros que visem à melhoria de sua condição: "seguro contra acidentes de trabalho, a cargo do empregador, sem excluir a indenização a que está obrigado, quando incorrer em dolo ou culpa". Trata-se de separação entre o regime da infortunística e o da reparação civil, reservada a possibilidade de concorrência entre seguro social a cargo do INSS e reparação cível, a cargo do empregador, esta última em caso de dolo, ou culpa. Inclui a tese de que com a adesão do diploma cível à responsabilidade independentemente de culpa, fundamentada na teoria do risco criado, a discussão envolvendo o tema retornou ao cenário jurídico, desta feita em novos tons. Conclui que o alicerce do entendimento que se firma é o caráter aberto do rol de direitos fundamentais, a permitir a conexão entre a cláusula geral de responsabilidade objetiva do Código Civil e o art. 5°, § 2° da Constituição Federal, norma receptora de outros direitos que, na essência, decorram do regime e dos princípios acolhidos pela CF, bem como o caráter aberto do art. 7º, caput da CF.
Progress and opportunities in gellan gum and collagen as wound healing materials: A review
Authors: Abu Bakar Aznatul Jannah binti , Mat Amin Khairul Anuar 
Published: January 2025

Gellan gum and collagen are two biomaterials that have been extensively studied for their potential use in wound healing and tissue engineering applications. Gellan gum is a biologically inert natural polymer that is increasingly favored as a biomaterial to form hydrogels. Collagen, on the other hand, is a major component of the extracellular matrix and is widely used in tissue engineering applications due to its biocompatibility and ability to promote cell adhesion and proliferation. In this review, the recent research will be discussed related to gellan gum and collagen, their properties, and their potential applications in wound healing and tissue engineering.
SISTEMA ORGANIZADOR DE ESTUDOS: UMA FERRAMENTA ESTRUTURADA PARA POTENCIALIZAR O SUCESSO EM CONCURSOS PÚBLICOS
Authors: Santos Aline Cardoso 
Published: January 2025

Os concursos públicos são uma das principais oportunidades para estudantes que buscam estabilidade e realização profissional. No entanto, a preparação para esses concursos é desafiadora e exige uma abordagem estratégica para se destacar em meio à forte concorrência.

Apesar de existirem diversos métodos de aprendizado como estudo ativo e passivo, a eficácia do estudo passivo, frequentemente subestimado, é questionada. O desafio é potencializar esse método de estudo para que ele se torne mais eficiente e contribua para o sucesso na preparação para concursos.

Este artigo tem como objetivo demonstrar os benefícios do Sistema Organizador de Estudo (SOE), uma ferramenta informatizada que utiliza Visual Basic para Excel, visando otimizar a organização e a eficácia dos estudos para concursos públicos.

A metodologia do SOE envolve a criação de planos de estudo adaptáveis, automatização de ciclos de revisão e monitoramento do desempenho do estudante. O sistema foi desenvolvido com base em princípios de design de sistemas e técnicas de organização do aprendizado. Sua eficácia foi validada por meio de estudos de caso, incluindo a análise de um servidor público federal aprovado em nove concursos públicos.

Os resultados dos estudos de caso indicaram que o SOE melhora a organização do tempo de estudo e reduz o tempo necessário para preparação, sem comprometer a qualidade do aprendizado. Além disso, o SOE se apresenta como uma alternativa acessível aos métodos tradicionais, como os cursos preparatórios. A utilização dessa ferramenta contribui para uma gestão de tempo mais eficiente e permite a personalização das estratégias de estudo, o que aumenta as chances de aprovação.

O estudo conclui que a integração de tecnologia simples e eficaz, como o SOE, pode transformar a preparação para concursos públicos, tornando-a mais estruturada, personalizada e orientada para o sucesso, contribuindo significativamente para o aumento das chances de aprovação.
A Comprehensive Literature Review of Effectiveness of Vitamin D and Physical Performance and Falls in Older Adults
Authors: Erick Persson Jeffry  , Charles Sanjaya Seikka  
Published: January 2025

Background: The effectiveness of vitamin D supplementation in enhancing physical performance and reducing falls among older adults has been a topic of considerable research and debate over the past several decades. Literature Review: Subsequent studies, such as the work by (M. Daly, 2010), further elucidated the importance of vitamin D in conjunction with exercise, highlighting that low serum 25(OH)D levels correlate with diminished muscle strength and increased fall risk. This relationship was echoed in research by (López-Torres Hidalgo, 2011), which demonstrated that combined calcium and vitamin D supplementation significantly improved musculoskeletal function and reduced falls among older adults. This points to the potential synergistic effects of these nutrients in promoting physical health. Meta-analyses, such as those conducted by (Bruyère et al., 2014) and (Rosendahl‐Riise et al., 2017), reinforced the notion that vitamin D supplementation can reduce falls and non-vertebral fractures, particularly at dosages of 700–1000 IU per day. These findings suggest a clear dose-response relationship, emphasizing the critical role of adequate vitamin D levels in maintaining muscle strength and balance, which are essential for fall prevention. However, the literature also highlights significant variability in outcomes, as noted in the systematic review by (Prokopidis et al., 2022). While some studies reported positive effects of vitamin D on muscle function, others yielded inconclusive results, pointing to the need for further research to clarify the role of vitamin D in combatting sarcopenia and its associated risks. Conclusion: In conclusion, the literature presents compelling evidence supporting the effectiveness of vitamin D supplementation in enhancing physical performance and reducing falls among older adults, particularly at higher dosages. Nonetheless, the inconsistencies in findings across various studies underscore the complexity of vitamin D's role in muscle health and fall prevention. Continued research is essential to refine supplementation strategies, address individual variability in vitamin D metabolism, and establish clear guidelines for effective interventions in older populations.