bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenomic Versus Genomic Prediction - A Comparison of Prediction Accuracies for Grain Yield in Hard Winter Wheat Lines
Authors: Winn Zachary J. , Amsberry Amanda L. , Haley Scott D. , DeWitt Noah D. , Mason R. Esten 
Published: July 2023

ABSTRACTCommon bread wheat (Triticum aestivumL.) is a key component of global diets, but the genetic improvement of wheat is not keeping pace with the growing demands of the world’s population. To increase efficiency and reduce costs, breeding programs are rapidly adopting the use of unoccupied aerial vehicles (UAVs) to conduct high-throughput spectral analyses. This study examined the effectiveness of multispectral indices in predicting grain yield compared to genomic prediction. Multispectral data were collected on advanced generation yield nursery trials during the 2019-2021 growing seasons in the Colorado State University Wheat Breeding Program. Genome-wide genotyping was performed on these advanced generations and all plots were harvested to measure grain yield. Two methods were used to predict grain yield: genomic estimated breeding values (GEBVs) generated by a genomic best linear unbiased prediction (gBLUP) model and phenomic phenotypic estimates (PPEs) using only spectral indices via multiple linear regression (MLR), k-nearest neighbors (KNN), and random forest (RF) models. In cross-validation, PPEs produced by MLR, KNN, and RF models had higher prediction accuracy (r̄: 0.41 ≤r̄≤ 0.48) than GEBVs produced by gBLUP (r̄= 0.35). In leave-one-year-out forward validation using only multispectral data for 2020 and 2021, PPEs from MLR and KNN models had higher prediction accuracy of grain yield than GEBVs of those same lines. These findings suggest that a limited number of spectra may produce PPEs that are more accurate than or equivalently accurate as GEBVs derived from gBLUP, and this method should be evaluated in earlier development material where sequencing is not feasible.
Spatial and long-term temporal evolution of a marine mussel hybrid zone (Mytilusspp.) in SW England
Authors: Diz Angel P. , Skibinski David O. F. 
Published: July 2023

AbstractThe study of spatial and temporal changes in hybrid zones offers important insights into speciation. Earlier studies on hybrid populations of the marine mussel speciesMytilus edulisandM. galloprovincialisin SW England provided evidence of admixture but were constrained by the limited number of molecular markers available. We use 57 highly ancestry-informative SNPs, most of which have been mapped genetically, to provide evidence of distinctive differences between highly admixed populations in SW England and asymmetrical introgression fromM. edulistoM. galloprovincialis. We combine the genetic study with analysis of phenotypic traits of potential ecological and adaptive significance. We demonstrate that hybrid individuals have brown mantle edges unlike the white or purple in the parental species, suggesting allelic or non-allelic genomic interactions. We report differences in gonad development stage between the species consistent with a prezygotic barrier between the species. By incorporating results from publications dating back to 1980 we confirm the long-term stability of the hybrid zone consistent with higher viability ofM. galloprovincialis. This stability coincides with a dramatic change in temperature of UK coastal waters and suggests that these hybrid populations might be resisting the effects of global warming. However, a single SNP locus associated with the notch 2 signalling transmembrane protein shows a markedly different pattern of variation to the others and might be associated with adaption ofM. galloprovincialisto colder northern temperatures.
Using dynamic biomaterials to study the temporal role of osteogenic growth peptide during osteogenesis
Authors: Fumasi Fallon M. , MacCulloch Tara , Bernal-Chanchavac Julio , Stephanopoulos Nicholas , Holloway Julianne L. 
Published: July 2023

AbstractThe extracellular matrix is a highly dynamic environment, and the precise temporal presentation of biochemical signals is critical for regulating cell behavior during development, healing, and disease progression. To mimic this behavior, we developed a modular DNA-based hydrogel platform to enable independent and reversible control over the immobilization of multiple biomolecules during in vitro cell culture. We combined reversible DNA handles with a norbornene-modified hyaluronic acid hydrogel to orthogonally add and remove multiple biomolecule-DNA conjugates at user-defined timepoints. We demonstrated that the persistent presentation of the cell adhesion peptide RGD was required to maintain cell spreading on hyaluronic acid hydrogels. Further, we discovered the delayed presentation of osteogenic growth peptide (OGP) increased alkaline phosphatase activity compared to other temporal variations. This finding is critically important when considering the design of OGP delivery approaches for bone repair. More broadly, this platform provides a unique approach to tease apart the temporal role of multiple biomolecules during development, regeneration, and disease progression.
Differential formation of motor cortical dynamics during movement preparation according to the predictability of go timing
Authors: Chae Soyoung , Sohn Jeong-Woo , Kim Sung-Phil 
Published: July 2023

AbstractMotor cortex not only executes but also prepares movement, as motor cortical neurons exhibit preparatory activity that predicts upcoming movements. In movement preparation, animals adopt different strategies in response to uncertainties existing in nature such as the unknown timing of when a predator will attack—an environmental cue informing ‘go’. However, how motor cortical neurons cope with such uncertainties is less understood. In this study, we aim to investigate whether and how preparatory activity is altered depending on the predictability of ‘go’ timing. We analyze firing activities of anterior lateral motor cortex (ALM) in mice during two auditory delayed-response tasks each with predictable or unpredictable go timing. When go timing is unpredictable, preparatory activities immediately reach and stay in a neural state capable of producing movement anytime to a sudden go cue. When go timing is predictable, preparation activity reaches the movement-producible state more gradually, to secure more accurate decisions. Surprisingly, this preparation process entails a longer reaction time (RT). We find that as preparatory activity increase in accuracy, it takes longer for a neural state to transition from the end of preparation to the start of movement. Our results suggest that motor cortex fine-tunes preparatory activity for more accurate movement using the predictability of go timing.Significant statementsAnticipating when to move is important in movement preparation. However, it is unclear how motor cortex prepares movement depending on how easy that anticipation is. To answer this, we examine motor cortical activity of mice during a delayed-response task. While motor cortical activity rapidly reaches a “movement-ready” state with unpredictable timing of a go signal (go timing), it does so more gradually when go timing is predictable. Moreover, when go timing is more predictable, motor cortex produces more accurate movement with, unexpectedly, a longer response time. This suggests that rodent motor cortical neurons can resource time information.
Unveiling ways to examine the purchase intension of green products in emerging markets
Authors: Lavuri Rambabu , Parida Ratri , Singh Sonia 
Published: July 2023

PurposeThis research study uses the theory of planned behavior to investigate the factors such as environmental concern, perceived control behavior and subjective norms that foster green purchasing intention in the developing market, with the moderating influence of environmental knowledge.Design/methodology/approachConvenience and purposive sampling were used to obtain data from 418 respondents, which were analyzed using structural equation modeling.FindingsThe findings revealed that environmental concern had a significant impact on the subjective norms, green attitude and perceived behavioral control; subjective norms had a positive impact on the green attitude, did not on perceived behavioral control and green purchase intention directly; perceived behavioral control had a significant impact on green attitude directly but did not green purchase intention; green attitude had a significantly impacted the green purchase intention. Environmental knowledge had a strong moderation association between green attitude and green purchase intention.Originality/valueThe study explores the complex relationships between various factors, including environmental concern, subjective norms, perceived behavioral control, green attitude and environmental knowledge, and their impact on green purchase intention which can provide a more nuanced understanding of the drivers for sustainable consumption. Additionally, the study's finding on the moderating effect of environmental knowledge on the relationship between green attitude and green purchase intention may be a novel contribution to the existing literature.
The effect of cold glow discharge nitrogen plasma treatment of sisal fiber (Agave Sisalana) on sisal fiber reinforced epoxy composite
Authors: Gupta Upendra S. , Tiwari Sudhir , Sharma Uttam 
Published: July 2023

Purpose
The incompatibility of natural fibers with polymer matrices is one of the key obstacles restricting their use in polymer composites. The interfacial connection between the fibers and the matrix was weak resulting in a lack of mechanical properties in the composites. Chemical treatments are often used to change the surface features of plant fibers, yet these treatments have significant drawbacks such as using substantial amounts of liquid and chemicals. Plasma modification has recently become very popular as a viable option as it is easy, dry, ecologically friendly, time-saving and reduces energy consumption. This paper aims to explore plasma treatment for improving the surface adhesion characteristics of sisal fibers (SFs) without compromising the mechanical attributes of the fiber.

Design/methodology/approach
A cold glow discharge plasma (CGDP) modification using N2 gas at varied power densities of 80 W and 120 W for 0.5 h was conducted to improve the surface morphology and interfacial compatibility of SF. The mechanical characteristics of unmodified and CGDP-modified SF-reinforced epoxy composite (SFREC) were examined as per the American Society for Testing and Materials standards.

Findings
The cold glow discharge nitrogen plasma treatment of SF at 120 W (30 min) enhanced the SFREC by nearly 122.75% superior interlaminar shear strength, 71.09% greater flexural strength, 84.22% higher tensile strength and 109.74% higher elongation. The combination of improved surface roughness and more effective lignocellulosic exposure has been responsible for the increase in the mechanical characteristics of treated composites. The development of hydrophobicity in the SF had been induced by CGDP N2 modification and enhanced the size of crystals and crystalline structure by removing some unwanted constituents of the SF and etching the smooth lignin-rich surface layer of the SF particularly revealed via FTIR and XRD.

Research limitations/implications
Chemical and physical treatments have been identified as the most efficient ways of treating the fiber surface. However, the huge amounts of liquids and chemicals needed in chemical methods and their exorbitant performance in terms of energy expenditure have limited their applicability in the past decades. The use of appropriate cohesion in addition to stimulating the biopolymer texture without changing its bulk polymer properties leads to the formation and establishment of plasma surface treatments that offer a unified, repeatable, cost-effective and environmentally benign replacement.

Originality/value
The authors are sure that this technology will be adopted by the polymer industry, aerospace, automotive and related sectors in the future.
Studying the properties of polypyrrole-montmorillonite polyacrylic-urethane nanocomposite coatings: the role of an eco-friendly ionic liquid
Authors: Amini Reza , Kardar Pooneh 
Published: July 2023

Purpose
This paper aims to achieve an anti-corrosive coating via uniform dispersion of nanoclay particles (montmorillonite) and polypyrrole (PPy) as a conductive polymer as well as their effects on the anti-corrosion features in the presence of the eco-friendly ionic liquids (ILs).

Design/methodology/approach
In this research, PPy with different forms of nanoclay were used. Moreover, ILs additive is used to enhance the better dispersion process of clay and PPy nanoparticles in the resin.

Findings
As a result, the IL additive in the formulation of nano-composite coatings greatly improves the dispersion process of clay and PPy nanoparticles in the resin. Due to its high compatibility with polyurethane resin and clay and PPy nanoparticles, this additive contains a high dispersing power to disperse the investigated nanoparticles in the resin matrix.

Research limitations/implications
High polarity of ILs as well as abilities to dissolve both mineral and organic materials, they can provide the better chemical processes compared to common solvents.

Practical implications
IL abilities have not been discovered to a large extent such as catalysts and detectors.

Social implications
ILs have been emerging as promising green solvents to replace conventional solvents in recent years. They possess unique properties such as nonvolatility, low toxicity, ease of handling, nonflammability and high ionic conductivity. Thus, they have received much attention as green media for various chemistry processes.

Originality/value
The simultaneous existence of clay, PPy and IL additive in the nano-composite coating formulation is responsible for the high corrosion resistance of the coating.
Conforming to Gender Stereotypes and Entrepreneurs’ Financing Outcomes
Authors: Liu Weixi , Cowling Marc 
Published: July 2023

AbstractRecent research into the gender aspects of small business financing has shown that in crisis periods, banks actively reward female entrepreneurs with privileged access to loans because they put forward more realistic and cautious funding proposals compared to hubristic male entrepreneurs. We build on this research by considering in greater detail how broader gender differences in entrepreneurial confidence play out in the context of bank lending. Further, we also question whether banks treat overconfident female entrepreneurs differently from their overconfident male counterparts. Our findings show that on average there is no discrimination, but if a female entrepreneur dares to exhibit overconfidence then this changes.
Radiation oncologists' scope of practice and role in cancer management in Australia, New Zealand, and Singapore: Are we clinicians or technicians?
Authors: Leung John , James Melissa , Adams Gerry , Gupta Nishant 
Published: July 2023

AbstractIntroductionTo evaluate the scope of practice and role in cancer management for radiation oncologists in Australia, New Zealand, and Singapore (ANZ).MethodsA 27‐question survey was emailed to all practicing radiation oncologists listed on the RANZCR database in mid‐2021.ResultsThere was a 54% response rate. Respondents reported managing symptoms associated with radiation therapy (96%), cancer‐related symptoms (86%), writing narcotic and analgesic prescriptions (76%), being involved in palliative care (57%), prescribing non‐cytotoxic systemic therapy (45%), and admitting patients (41%). Just over 20% wanted to expand their scope of practice, but for those who were unable to, insufficient time (35%), inter‐specialty political difficulties (14%), and lack of support from the organisation (12%) were the major reasons. Over half of respondents (56.4%) thought they provided an opinion on the overall role of cancer management. Just under 20% provided a radiation therapy opinion only and <1% provided radiation therapy at the request of the referring clinician. The remainder reported a combination of these. Over 80% of respondents thought their ideal role was to be involved in overall cancer management and 20% believed they should be providing an opinion on radiation therapy only. The ideal role matched the actual role in over 87% of respondents and most respondents thought radiation oncology training enabled an opinion on overall cancer management. Over 90% of respondents were satisfied with their current role in cancer management. Radiation oncologists felt they were perceived as independent clinicians and the large majority (87%) thought radiation oncologists should be part of a multidisciplinary team rather than leaders in cancer management.ConclusionThis study has revealed a broad but expected scope of practice for ANZ radiation oncologists with the large majority providing an opinion on overall cancer management or radiation therapy and their ideal role matching their actual role.
The rs72613567:TA polymorphism in HSD17B13 is associated with survival benefit after development of hepatocellular carcinoma
Authors: Innes Hamish , Morgan Marsha Y. , Hampe Jochen , Stickel Felix , Buch Stephan 
Published: July 2023

SummaryBackgroundThe influence of genetic factors on survival following a diagnosis of hepatocellular carcinoma (HCC) remains unclear.AimTo assess whether genetic polymorphisms influencing the susceptibility to develop HCC are also associated with HCC prognosis.MethodsWe included United Kingdom Biobank (UKB) participants diagnosed with HCC after study enrolment. The primary outcome was all‐cause mortality. Patients were followed from the date of HCC diagnosis to death or the registry completion date. Five HCC susceptibility loci were investigated: rs738409 (PNPLA3), rs58542926 (TM6SF2); rs72613567 (HSD17B13); rs2242652 (TERT) and rs708113 (WNT3A). The associations between these genetic variants and HCC mortality risk were assessed using Cox regression, adjusted for age, sex, ethnicity, aetiology, severity of the underlying liver disease and receipt of curative HCC treatment.ResultsThe final sample included 439 patients; 74% had either non‐alcoholic fatty liver disease or alcohol‐related liver disease. There were 321 deaths during a mean follow‐up of 1.9 years per participant. Kaplan–Meier survival estimates at 1, 3 and 5 years were 53.2%, 31.2% and 22.6% respectively.In multivariate analysis, rs72613567:TA (HSD17B13) was the only genetic susceptibility variant significantly associated with all‐cause mortality risk (aHR: 0.74; 95% CI: 0.61–0.90; p = 0.003). Other associated factors were Baveno stage 3–4 (aHR: 1.65; 95% CI: 1.05–2.59; p = 0.03) and HCC treatment with curative intent (aHR: 0.25; 95% CI: 0.17–0.37; p < 0.001).ConclusionsThe rs72613567:TA polymorphism in HSD17B13 is not only associated with a reduction in the risk of developing HCC but with a survival benefit in HCC once established. Therapeutic inhibition of HSD17B13 may augment survival in individuals with HCC.
Bachmann–Bupp syndrome and treatment
Authors: Bachmann André S. , VanSickle Elizabeth A. , Michael Julianne , Vipond Marlie , Bupp Caleb P. 
Published: July 2023

AbstractBachmann–Bupp syndrome (BABS) is a neurodevelopmental disorder characterized by developmental delay, hypotonia, and varying forms of non‐congenital alopecia. The condition is caused by 3′‐end mutations of the ornithine decarboxylase 1 (ODC1) gene, which produce carboxy (C)‐terminally truncated variants of ODC, a pyridoxal 5′‐phosphate‐dependent enzyme. C‐terminal truncation of ODC prevents its ubiquitin‐independent proteasomal degradation and leads to cellular accumulation of ODC enzyme that remains catalytically active. ODC is the first rate‐limiting enzyme that converts ornithine to putrescine in the polyamine pathway. Polyamines (putrescine, spermidine, spermine) are aliphatic molecules found in all forms of life and are important during embryogenesis, organogenesis, and tumorigenesis. BABS is an ultra‐rare condition with few reported cases, but it serves as a convincing example for drug repurposing therapy. α‐Difluoromethylornithine (DFMO, also known as eflornithine) is an ODC inhibitor with a strong safety profile in pediatric use for neuroblastoma and other cancers as well as West African sleeping sickness (trypanosomiasis). Patients with BABS have been treated with DFMO and have shown improvement in hair growth, muscle tone, and development.
Stocks and flows: Material culture and consumption behaviour in early modern Venice (c. 1650–1800)
Authors: Viale Mattia 
Published: July 2023

AbstractThis paper examines the evolution of consumption practices in Venice in the long eighteenth century through the combined use of post‐mortem inventories and household budgets. Although Italy experienced a period of relative decline between the seventeenth and eighteenth centuries, our findings suggest that Venetian households enjoyed a rich and vibrant material culture that was fully comparable with those of the most advanced European urban economies. However, although new products, practices, and fashions were adopted by Venetian society, the architecture of consumption did not undergo sudden and extreme changes; rather, consumption was gradually refined, following the path that it had begun during the Renaissance. We therefore argue that the Venetian economy did not experience a consumer revolution but, instead, consumer evolution. Moreover, this study shows that sophisticated consumption practices were not exclusive to the more dynamic economies of the continent but were widespread even in those regions that were victims of the Little Divergence. We thus suggest that the relationship between consumption development and economic development was not necessarily causal and that the diffusion of new consumption practices throughout society was a necessary, but insufficient, prerequisite for economic take‐off.
Rethinking the history of British popular culture, 1850–1914
Authors: McWilliam Rohan 
Published: July 2023

AbstractThis article explores the way in which the history of Victorian popular culture has been rethought by historians since 2000. In the mid to late 20th century, the social history of leisure was often shaped by Marxist assumptions and devoted to emphasising the role of social class in determining forms of pleasure. In the 21st century historiography, class still matters but so do issues around race, gender and space.