bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coinfections of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review and individual participant data meta-analysis protocol
Authors: Sorano Sumire , Gore-Langton Georgia , Opondo Charles , Smith Chris , Matsui Mitsuaki , Chaponda Enesia Banda , Chandramohan Daniel , Chico R Matthew 
Published: June 2023

IntroductionMalaria infection and curable sexually transmitted infections and reproductive tract infections (STIs/RTIs) adversely impact pregnancy outcomes. In sub-Saharan Africa, the prevalence of malaria and curable STIs/RTIs is high and, where coinfection is common, combination interventions may be needed to improve pregnancy outcomes. The aim of this systematic review is to estimate the prevalence of malaria and curable STI/RTI coinfection during pregnancy, risk factors for coinfection and prevalence of associated adverse pregnancy outcomes.Methods and analysisWe will use three electronic databases, PubMed, EMBASE and Malaria in Pregnancy Library to identify studies involving pregnant women attending routine antenatal care facilities in sub-Saharan Africa and reporting malaria and curable STI/RTI test results, published in any language since 2000. We will search databases in the second quarter of 2023 and repeat the search before completion of our analyses. The first two authors will screen titles and abstracts, selecting studies that meet inclusion criteria and qualify for full-text screening. If agreement on inclusion/exclusion cannot be reached, the last author will serve as arbiter. We will extract data from eligible publications for a study-level meta-analysis. We will contact research groups of included studies and request individual participant data for meta-analysis. The first two authors will conduct a quality appraisal of included studies using the GRADE system. The last author will adjudicate if the first two authors do not agree on any appraisals. We will conduct sensitivity analyses to test the robustness of effect estimates over time (by decade and half-decade periods), geography (East/Southern Africa vs West/Central Africa), gravidity (primigravidae, secundigravidae, multigravidae), treatment type and dosing frequency, and malaria transmission intensity.Ethics and disseminationWe obtained ethics approval from the London School of Hygiene & Tropical Medicine (LSHTM Ethics Ref: 26167). Results of this study will be disseminated via peer-reviewed publication and presentation at scientific conferences.PROSPERO registration numberCRD42021224294.
The assignments of the $$B_s$$ mesons within the screened potential model and $$^3P_0$$ model
Authors: Hao Wei , Lu Yu , Wang En 
Published: June 2023

AbstractWe investigate the mass spectrum and the decay properties of the$$B_s$$Bsmesons within the screened nonrelativistic quark model and the$$^3P_0$$3P0model. Our results suggest that the$$B_{sJ}(6064)$$BsJ(6064)and$$B_{sJ}(6114)$$BsJ(6114)states, as the first solution of the recently LHCb measurements, could be explained as the$$B_s(1^3D_3)$$Bs(13D3)and$$B_s(1^3D_1)$$Bs(13D1), respectively. In addition, the$$B_{sJ}(6109)$$BsJ(6109)and$$B_{sJ}(6158)$$BsJ(6158)states, as the second solution of the LHCb measurements, could be explained as the$$B_{s2}^\prime (1D)$$Bs2′(1D)and$$B_{s1}(2P)$$Bs1(2P), respectively. Meanwhile, the$$B_{s1}(5830)$$Bs1(5830)could be interpreted as the candidate of the$$B_{s1}(1P)$$Bs1(1P). We also calculated the decay properties of the other excited$$B_s$$Bsmesons with the predicted masses, which should be helpful for the experimental searching in future.
Quantum avoidance of Gödel’s closed timelike curves
Authors: Zhao Zhe , Modesto Leonardo 
Published: June 2023

AbstractIn a large class of nonlocal as well as local higher derivative theories minimally coupled to the matter sector, we investigate the exactness of two different classes of homogeneous Gödel-type solutions, which may or may not allow closed time-like curves (CTC). Our analysis is limited to spacetimes solving the Einstein’s EoM, thus we can not exclude the presence of other Gödel-type solutions solving the EoM of local and nonlocal higher derivative theories but not the Einstein’s EoM. It turns out that the homogeneous Gödel spacetimes without CTC are basically exact solutions for all theories, while the metrics with CTC are not exact solutions of (super-)renormalizable local or nonlocal gravitational theories. Hence, the quantum renormalizability property excludes theories suffering of the Gödel’s causality violation. We also comment about nonlocal gravity non-minimally coupled to matter. In this class of theories, all the Gödel’s spacetimes, with or without CTC, are exact solutions at classical level. However, the quantum corrections, although perturbative, very likely spoil the exactness of such solutions. Therefore, we can state that the Gödel’s Universes with CTC and the super-renormalizability are mutually exclusive.
A polyhedral approach to the arithmetic and geometry of hyperbolic link complements
Authors: Kellerhals Ruth 
Published: June 2023

We provide an elementary polyhedral approach to study and deduce results about the arithmeticity and commensurability of an infinite family of hyperbolic link complements [Formula: see text] for [Formula: see text]. The manifold [Formula: see text] is the complement of [Formula: see text] by the ([Formula: see text])-link chain [Formula: see text] and has [Formula: see text] cusps. We show that [Formula: see text] is closely related to a hyperbolic Coxeter orbifold that is commensurable to an orbifold with a single cusp. Vinberg’s arithmeticity criterion and certain cusp density and volume computations allow us to reproduce some of the main results in [20] and [18] about [Formula: see text] in a comparatively elementary and direct way. As a by-product, we give a rigorous proof of Thurston’s volume formula for [Formula: see text] and deduce that, for [Formula: see text], the volume of [Formula: see text] is strictly bigger than the volume of the ([Formula: see text])-cyclic cover over one component of the Whitehead link.
The Prognostic Effect of Immune Cell Infiltration Depends on Molecular Subtype in Endometrioid Ovarian Carcinomas
Authors: Heinze Karolin , Cairns Evan S. , Thornton Shelby , Harris Bronwyn , Milne Katy , Grube Marcel , Meyer Charlotte , Karnezis Anthony N. , Fereday Sian , Garsed Dale W. , Leung Samuel C.Y. , Chiu Derek S. , Moubarak Malak , Harter Philipp , Heitz Florian , McAlpine Jessica N. , DeFazio Anna , Bowtell David D.L. , Goode Ellen L. , Pike Malcolm , Ramus Susan J. , Pearce C. Leigh , Staebler Annette , Köbel Martin , Kommoss Stefan , Talhouk Aline , Nelson Brad H. , Anglesio Michael S. 
Published: June 2023

Abstract

Purpose:
Endometrioid ovarian carcinoma (ENOC) is the second most-common type of ovarian carcinoma, comprising 10%–20% of cases. Recently, the study of ENOC has benefitted from comparisons to endometrial carcinomas including defining ENOC with four prognostic molecular subtypes. Each subtype suggests differential mechanisms of progression, although tumor-initiating events remain elusive. There is evidence that the ovarian microenvironment may be critical to early lesion establishment and progression. However, while immune infiltrates have been well studied in high-grade serous ovarian carcinoma, studies in ENOC are limited.

Experimental Design:
We report on 210 ENOC, with clinical follow-up and molecular subtype annotation. Using multiplex IHC and immunofluorescence, we examine the prevalence of T-cell lineage, B-cell lineage, macrophages, and populations with programmed cell death protein 1 or programmed death-ligand 1 across subtypes of ENOC.

Results:
Immune cell infiltrates in tumor epithelium and stroma showed higher densities in ENOC subtypes with known high mutation burden (POLEmut and MMRd). While molecular subtypes were prognostically significant, immune infiltrates were not (overall survival P &gt; 0.2). Analysis by molecular subtype revealed that immune cell density was prognostically significant in only the no specific molecular profile (NSMP) subtype, where immune infiltrates lacking B cells (TILB minus) had inferior outcome (disease-specific survival: HR, 4.0; 95% confidence interval, 1.1–14.7; P &lt; 0.05). Similar to endometrial carcinomas, molecular subtype stratification was generally superior to immune response in predicting outcomes.

Conclusions:
Subtype stratification is critical for better understanding of ENOC, in particular the distribution and prognostic significance of immune cell infiltrates. The role of B cells in the immune response within NSMP tumors warrants further study.
Deferred Versus Performed Revascularization for Left Main Coronary Disease With Hemodynamic Significance
Authors: Warisawa Takayuki , Cook Christopher M. , Ahmad Yousif , Howard James P. , Seligman Henry , Rajkumar Christopher , Toya Takumi , Doi Shunichi , Nakajima Akihiro , Nakayama Masafumi , Vera-Urquiza Rafael , Yuasa Sonoka , Sato Takao , Kikuta Yuetsu , Kawase Yoshiaki , Nishina Hidetaka , Al-Lamee Rasha , Sen Sayan , Lerman Amir , Matsuo Hitoshi , Akashi Yoshihiro J. , Escaned Javier , Davies Justin E. 
Published: June 2023

Background:
The majority of randomized controlled trials of revascularization decision-making excludes left main coronary artery disease (LMD). Therefore, contemporary clinical outcomes of patients with stable coronary artery disease and LMD with proven ischemia remain poorly understood. The aim of this study was to assess the long-term clinical outcomes of physiologically significant LMD according to the treatment strategies of revascularization versus revascularization deferral.

Methods:
In this international multicenter registry of stable LMD interrogated with the instantaneous wave-free ratio, patients with physiologically significant ischemia (instantaneous wave-free ratio ≤0.89) were analyzed according to the coronary revascularization (n=151) versus revascularization deferral (n=74). Propensity score matching was performed to adjust for baseline clinical characteristics. The primary end point was a composite of death, nonfatal myocardial infarction, and ischemia-driven target lesion revascularization of left main stem. The secondary end points were as follows: cardiac death or spontaneous LMD-related myocardial infarction; and ischemia-driven target lesion revascularization of left main stem.

Results:

At a median follow-up period of 2.8 years, the primary end point occurred in 11 patients (14.9%) in the revascularized group and 21 patients (28.4%) in the deferred group (hazard ratio, 0.42 [95% CI, 0.20–0.89];
P
=0.023). For the secondary end points, cardiac death or LMD-related myocardial infarction occurred significantly less frequently in the revascularized group (0.0% versus 8.1%;
P
=0.004). The rate of ischemia-driven target lesion revascularization of left main stem was also significantly lower in the revascularized group (5.4% versus 17.6%; hazard ratio, 0.20 [95% CI, 0.056–0.70];
P
=0.012).

Conclusions:
In patients who underwent revascularization for stable coronary artery disease and physiologically significant LMD determined by instantaneous wave-free ratio, the long-term clinical outcomes were significantly improved as compared with those in whom revascularization was deferred.
Reperfusion Delays and Outcomes Among Patients With ST-Segment–Elevation Myocardial Infarction With and Without Cardiogenic Shock
Authors: Kochan Andrew , Lee Terry , Moghaddam Nima , Milley Grace , Singer Joel , Cairns John A. , Wong Graham C. , Jentzer Jacob C. , van Diepen Sean , Alviar Carlos , Fordyce Christopher B. 
Published: June 2023

Background:
Mortality remains high in patients with ST-segment–elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS), and early reperfusion has been shown to improve outcomes. We analyzed the association between first medical contact (FMC)-to-percutaneous coronary angiography time with mortality and major adverse cardiovascular events among patients with STEMI with and without CS.

Methods:
We performed a retrospective analysis of the Vancouver Coastal Health Authority STEMI registry, including all patients with STEMI who received primary percutaneous coronary angiography between January 1, 2010, and December 31, 2020, and stratified them by presence or absence of CS at hospital arrival. The primary outcome was in-hospital mortality, the secondary outcome was in-hospital major adverse cardiovascular events, defined as a composite of the first occurrence of mortality, cardiac arrest, heart failure, intracerebral hemorrhage, cerebrovascular accident, or reinfarction. Mixed effects logistic regression with restricted cubic splines was used to estimate the relationships between FMC-to-device time and the outcomes in the CS and non-CS groups.

Results:

2929 patients were included, 9.4% (n=275) had CS. Median FMC-to-device time was 113.5 (interquartile range, 93.0–145.0) and 103.0 (interquartile range, 85.0–130.0) minutes for patients with CS and without CS, respectively. More patients with CS had FMC-to-device times above guideline recommendations (76.6% versus 54.1%,
P
<0.001). Between 60 and 90 minutes, for each 10-minute increase in FMC-to-device time, absolute mortality for patients with CS increased by 4% to 7%, whereas for patients without CS, it increased by <0.5%.

Conclusions:
Among patients with STEMI undergoing primary percutaneous coronary angiography, reperfusion delays among patients with CS are associated with significantly worse outcomes. Strategies to reduce FMC-to-device times for patients with STEMI presenting with CS are required.
‘Abstract Labour and Socialism’: An Introduction
Authors: Salour Sam 
Published: June 2023

Abstract
The article aims to introduce the works of eminent Iranian Marxist theoretician, Kamal Khosravi, to Western readers. Over the past few decades, Khosravi has written extensively on Marx, Marxism, and Marxist methodology. Through translations and his own writings, he has worked tirelessly to introduce Iranian readers to the rich debates on Marxist methodology and value theory that have developed in the West since the 1960s. More recently, as the lead editor of the Iranian journal Critique, his writings are having an influence on the ongoing social movements as they are being disseminated and discussed amongst activists and labour leaders. In this article, we situate his writings within the developments of Iranian and Western Marxism.
Impact of aortoceliac angle in implantation of subcutaneous hepatic artery port-catheter system for hepatic arterial infusion chemotherapy via femoral approach
Authors: Kim Su Ho , Chun Ho Jong , Kim Youdong , Oh Jung Suk , Choi Byung Gil , Lee Hae Giu 
Published: June 2023

Background In patients with an acute aortoceliac angle, the diagnostic catheter often fails to enter the common hepatic artery. Purpose To retrospectively evaluate the impact of aortoceliac angle on the implantation of a port-catheter system via a femoral approach for hepatic arterial infusion chemotherapy (HAIC) in patients with advanced hepatocellular carcinoma (HCC). Material and Methods A total of 399 patients with advanced HCC underwent percutaneous implantation of a port-catheter system for HAIC. Among these patients, 383 underwent successful implantation via a femoral artery approach (success group). In 16 patients, port-catheter systems were implanted via a subclavian artery approach (failure group) after failure of the initial attempt via the femoral artery due to failed catheter tip fixation to the gastroduodenal artery. We statistically analyzed aortoceliac angle, ostial celiac stenosis, sex, age, weight, height, and body mass index (BMI) between groups. Results The average aortoceliac angle, weight, and BMI were significantly different between the two groups ( P < 0.001, P = 0.02, P < 0.001, respectively). Among them, only the aortoceliac angle was a significant risk factor in logistic regression analysis. The smaller the aortoceliac angle, the more often the femoral approach failed ( P < 0.001, odds ratio = 0.817, 95% confidence interval = 0.752–0.887). There were no significant differences in ostial celiac stenosis, sex, or age between the two groups ( P = 0.549, 0.056, 0.173, and 0.773, respectively). Conclusion For patients with an acute aortoceliac angle, the femoral approach is likely to fail. A subclavian artery approach should be preferentially considered for percutaneous implantation of a port-catheter system in such patients.
Exploring the Relationship Between Extent of Person-Centered Care Implementation and Staffing Levels in Ohio Nursing Homes
Authors: Kunkel Miranda C. , Bowblis John R. , Straker Jane K. , Van Haitsma Kimberly , Abbott Katherine M. 
Published: June 2023

Background: The Preferences for Everyday Living Inventory (PELI) is a person-centered care (PCC) tool that uncovers/honors older adults’ important preferences. PCC implementation in nursing homes (NHs) often requires additional resources, such as staff time. We explored if PELI implementation is associated with NH staffing levels. Methods: Using NH-year as the unit of observation ( n = 1307), 2015 and 2017 data from Ohio NHs was used to examine the relationship between complete versus partial PELI implementation and staffing levels, measured in hours per resident day, for various positions and total nursing staff. Results: Complete PELI implementation was associated with higher nursing staff levels in both for-profits and not-for-profits; however, total nursing staff levels in not-for-profits were higher than for-profits (0.16 vs. 0.09 hours per resident day). The specific nursing staff associated with PELI implementation varied by ownership. Discussion: For NHs to fully implement PCC, a multifaceted approach to improve staffing is needed.
Comparison of COVID-19 Preprint and Peer-Reviewed Versions of Studies on Therapies for Critically Ill Patients
Authors: Morin Conor , Padki Anirudh , Wong Adrian , Miano Todd , Kane-Gill Sandra L. , Cozzi Gabrielle , Deveau Robert 
Published: June 2023

Purpose Significant increases in the volume of preprint articles due to the COVID-19 pandemic, we examined the reliability of preprint articles compared to their peer-reviewed publications. Materials and Methods Preprint articles evaluating experimental studies of select treatment options (anticoagulation, dexamethasone, hydroxychloroquine, remdesivir, and tocilizumab) for COVID-19 in the critically ill, available in a peer-reviewed publication were screened for inclusion within Altmetric (n = 2040). A total of 40 articles met inclusion criteria, with 21 being randomly selected for evaluation. The primary outcome of this evaluation was a change in a study's reported primary outcome or statistical significance between preprint and peer-reviewed articles. Secondary outcomes included changes in primary/secondary outcome effect size and change in study conclusion. Results One article (4.8%, 95% CI 0.12%-23.8%) had a change in the primary outcome. Seven articles (33.3%, 95% CI 14.6%-57.0%) had a change in the primary outcome's effect measure. Five studies (23.8%, 95% CI 8.2%-47.2%) had changes in statistical significance of at least one secondary outcome. Four studies (19.0%, 95% CI 5.4%-41.9%) had a change in study conclusion. Conclusions In preprint articles of COVID-19 treatments, the provided primary outcome is generally reliable, while interpretation of secondary outcomes should be made with caution, while awaiting completion of the peer-review process.
Influence of Weight and Body Size on the Pharmacokinetics of Heart Failure Pharmacotherapy: A Systematic Review
Authors: Hindi Jessica , Fréchette-Le Bel Myriam , Rouleau Jean Lucien , de Denus Simon 
Published: June 2023

Objective: To conduct a review of studies evaluating the influence of body size and weight (WT) on the pharmacokinetics (PK) of drugs recommended for heart failure (HF) treatment. Data Sources: A systematic search of the MEDLINE (1946 to April 2023) and EMBASE (1974 to April 2023) databases was conducted for articles that focused on the impact of WT or body size on the PK of drugs of interest used in HF patients. Study Selection and Data Extraction: Articles written in English or French related to the aim of our study were retained for analysis. Data Synthesis: Of 6493 articles, 20 were retained for analysis. Weight was associated with the clearance of digoxin, carvedilol, enalapril, and candesartan as well as the volume of distribution of eplerenone and bisoprolol. There was no documented direct impact of WT on the PK of furosemide, valsartan, and metoprolol, although these studies were limited or confounded by the small sample size, adjustment of PK factors by WT, or the use of the Cockroff-Gault equation for the evaluation of creatinine clearance, which includes WT. Relevance to Patient Care and Clinical Practice: This review highlights and summarizes the available data on the importance of WT on the PK of HF treatment. Conclusion: Considering the significant impact of WT on most HF drugs in this review, it may be important to further investigate it in the context of personalized therapy, particularly in patients presenting extreme WTs.
Understanding youth circumstances in workforce development programs: Opportunities for social work
Authors: Collins Mary Elizabeth , Spindle-Jackson Adrianna 
Published: June 2023

Summary Youth who are disconnected from both education and work are at risk for a difficult life trajectory. This population requires policy and practice attention from social work. In this article, we report results from two research studies in the United States focused on the workforce development system serving the disconnected youth population. Qualitative interviews were conducted with 61 respondents in various geographic areas. Findings The focus of the analysis was data related to youth strengths and employment-related realities. Additionally, we examined the extent to which social work was reportedly engaged in this work. Respondents identified strengths of the youth population to include resilience, creativity, and willingness to contribute their perspectives. The described realities of employment suggest many challenges (e.g., employer reluctance, limited information on opportunities, and immediate economic realities). Social work was only mentioned in a few instances but in a positive light. Applications The findings have direct application for guiding further social work engagement in this practice and policy area. These applications include providing leadership to workforce development systems in the use of strengths perspectives, meeting youth where they are at, engaging in holistic interventions to address basic needs, and strengthening collaborations. Applications to social work research and education are also identified.