bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensus and Dissensus Communis
Authors: Früchtl Josef 
Published: December 2022

The thesis of the article is that within the framework of Western culture the cinematic comedy again and again can be seen as an aesthetic form where passions for democracy take their way. Following Cavell, philosophy, first, is as a matter of the "human voice" which is, in reference to Kant's third Critique, a "universal voice". The aesthetic judgement insofar is a model of philosophical and, secondly, of democratic judgement. For in Kant, arguing about aesthetic matters means facilitating the communitarisation of confrontation. "Common sense" (sensus communis) is the political term Kant offers for this. Since this term, thirdly, has recently again been appropriated by populist semantics, it is important to stress a radically democratic, with Cavell: a romantic conception of democracy, and to this conception, fourth, the art form of comedy corresponds. Comedy and democracy both centre around "the common, the familiar, the low", and in laughter give this human-social sphere both an anarchic-democratic level of meaning and a certain, humorous self-reflection. The movie Adam's Rib finally works as an example for this.
Merleau-Ponty reader of Goldstein: what is organismic intentionality?
Authors: Müller Marcos José 
Published: December 2022

Abstract: The present study proposes an investigation into the reasons why Merleau-Ponty recognizes, in Goldstein’s incorporation of the figure-ground notion from the Gestalt Psychology, the convergence between contemporary science and phenomenological philosophy. It is about understanding how, insofar as it reveals the power of centering that operates in the concreteness of the existence of organisms in the surroundings, the notion of figure-background corresponds to the phenomenological notion of operative intentionality. In the same way, it is a matter of showing in what sense, as a form of operative intentionality, the power of centering of organisms does not need to be based on the presupposition of an “I think”.
Keywords: Merleau-Ponty; Goldstein; Gestalt; organismic intentionality
Neither Theory nor Science Metaphilosophical Remarks on Philosophical Elucidations
Authors: Reinoso Guadalupe 
Published: December 2022

This article examines Wittgenstein’s philosophical reflection on philosophy: its method, its scope, and its relationship with other knowledge as central elements of the philosophical proposal the author developed in Tractatus Logico-Philosophicus. Therefore, my proposal is to rehearse a metaphilosophical reading of Wittgenstein’s remarks about philosophy in TLP focusing, on the one hand, on his reflections on philosophy as an activity and not as a theory; on the other hand, on his categorical differentiation established between philosophical elucidations and scientific explanations.
This proposal differs from the readings that interpret it is through the construction of a theory of meaning -or logical doctrine- that one can distinguish philosophical nonsense and see the world correctly. It also differs from Tractatus’s non-theoretical or quietist readings which understand philosophical elucidations as exclusively negative or critical nonsense. My aim is to highlight a positive aspect of philosophical elucidations that I will call performative. From my metaphilosophical reading, not only does the activity of clarification work as a critical sieve that separates what makes sense from what does not –with no theory; but it also makes a modification -a transformation- in the one who establishes it. These performative aspects imply emphasizing that there is a change in the way we see the world but also in the way we ‘see’ language, meaning, logic, science, philosophy, life, etc. Thus, the refusal to elaborate a theory or to offer scientific explanations does not turn the philosophical elucidations in TLP into a mode of self-destructive attack on all kinds of philosophy. On the contrary, these elucidations are part of the defense of a particular way of practicing it.
OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma
Authors: Wang Ying , Li Yadong , Jiang Xuanwei , Gu Yayun , Zheng Hui , Wang Xiaoxuan , Zhang Haotian , Wu Jixiang , Cheng Yang 
Published: December 2022

Background
Mitochondrial fusion and fission were identified to play key roles during multiple biology process. Thus, we aim to investigate the roles of OPA1 in mitochondria fusion and immune evasion of non-small cell lung cancer cells.

Methods
The transcriptional activation of genes related to mitochondrial dynamics was determined by using multi-omics data in lung adenocarcinoma (LUAD). We elucidated the molecular mechanism and roles of OPA1 promoting lung cancer through single-cell sequencing and molecular biological experiments.

Results
Here, we found that copy number amplification of OPA1 and MFN1 were co-occurring and synergistically activated in tumor epithelial cells in lung cancer tissues. Both of OPA1 and MFN1 were highly expressed in LUAD tumor tissues and OPA1 high expression was associated with poor prognosis. In terms of mechanism, the damaged mitochondria activated the apoptotic signaling pathways, inducing cell cycle arrest and cell apoptosis. More interestingly, OPA1 deficiency damaged mitochondrial dynamics and further blocked the respiratory function to increase the sensitivity of tumor epithelial to CD8+ T cells in non-small cell lung cancer.

Conclusions
Our study demonstrated the high co-occurrence of copy number amplification and co-expression of OPA1 and MFN1 in LUAD tissue, and further revealed the contribution of OPA1 in maintaining the mitochondria respiratory function and the ability of immune evasion to CD8+ T cells of LUAD.
Market Integration and Price Transmission Analysis of Onion in Wholesale Markets of India
Authors: Kumar Mohit , Shaikh A. S. , Sharma Rohit Kumar 
Published: December 2022

The present study was done in seven major onion wholesale markets in India, namely Pimpalgaon, Lasalgaon, Solapur, Pune, Bangalore, Hyderabad and Indore to explore the interdependence of wholesale prices amongst Indian onion markets. The study was conducted in all India perspective and the study period involves the seventeen years data of onion wholesale prices (January 2004 to December 2020). The study was majorly based on the prices of onion obtained through secondary source. These data were collected from various portals such as FAO, NHRDF, Agmarknet and NHB. The current study employs co-integration analysis of wholesale monthly onion prices in selected marketplaces to determine the degree of market integration. The Trace and Maximum Eigen-value tests results showed that the onion prices in India moves together in the long run equilibrium. As a result, it may be stated that India's onion markets are well-functioning. The direction of information flow was determined by using Granger Causality test. It was found that in few markets pairs, price transmissions were bi-directional whereas between Bangalore and Pune market, no transmission was found. The study reveals that Lasalgaon market is dominating in terms of price determination. The empirical study also recommends keeping a careful eye on diverse market behavioural patterns, since "news" in one market might have an influence on other markets due to the numerous interdependencies.
Exposição a dieta hiperlipídica no período perinatal e pós desmame aumenta risco cardiometabólico e altera histomorfometria aórtica em ratos jovens
Authors: Da Anunciação do Espírito Santo Djane , Pereira Conceição Machado Maria Ester , Alves Pereira Vivian Alves , Alves Chagas Mauricio , Teles Boaventura Gilson , Barreto Medeiros Jairza Maria 
Published: December 2022

Introdução: Estudos sugerem forte associação da exposição intrauterina e pós-natal a dietas hiperlipídicas e complicações cardiovasculares. Objetivo: avaliar efeitos da exposição a dieta hiperlipídica no período perinatal e pós desmame sobre indicadores de risco cardiometabólico e alterações histomorfometrica aórtica em ratos. Metodologia: Ratas Wistar gestantes foram separadas em grupos: controle (n=3) e hiperlipídica (n=3). No 21º dia descendentes foram divididos em subgrupos (n=6) de acordo com a manipulação nutricional: grupo (CC) formado por animais que consumiram dieta controle, grupo (CH) formado por animais que a mãe consumiu dieta controle e após o desmame os descendentes consumiram dieta hiperlipídica, grupo (HH) formado por descendentes que consumiram apenas dieta hiperlipídica e grupo (HC) formado por animais que a mãe consumiu dieta hiperlipídica e após o desmame os descendentes consumiram dieta controle. No 60º dia índices aterogênicos, proteína C reativa e histomorfometria da aorta dos descendentes foram avaliados. Resultados: Grupo CH apresentou maior razão colesterol total / HDL-colesterol e colesterol não-HDL / HDL-colesterol (coeficiente aterogênico) em comparação ao grupo CC (p < 0,01). Espessura da aorta dos grupos CH e HH foram maiores que CC e HC (p < 0,01). As lamelas elásticas do grupo HH apresentaram maior espessura em comparação a HC e CC (p < 0,001). A quantidade de lamelas elásticas foi maior nos grupos CH e HH em comparação a CC e HC (p < 0, 01). Conclusão: exposição a dieta hiperlipídica nos períodos perinatal e pós desmame aumentou o risco cardiometabólico e alterou a histomorfometria aórtica em ratos.
Risco pré-operatório de coledocolitíase em colecistectomias em um hospital terciário de João Pessoa-PB
Authors: Leite Veloso Olga Lanusa , Gomes da Silva Diego Arley , Gonçalves Sousa Marcelo 
Published: December 2022

Introdução: a colelitíase é uma das doenças mais comuns do trato digestivo, acometendo 6-10% da população adulta. Destes, aproximadamente 8- 20% apresentam coledocolitíase associada. A estratificação de risco de coledocolitíase pré-operatória nos portadores de colelitíase busca subsidiar a definição de uma terapêutica mais adequada, em tempo hábil, para cada caso. Objetivo: estratificar o risco pré-operatório de coledocolitíase em pacientes submetidos a colecistectomia em um hospital terciário. Metodologia: estudo observacional descritivo, retrospectivo, a partir da análise de prontuários de pacientes submetidos a colecistectomia por cálculos biliares em um hospital público em João Pessoa, Paraíba, entre agosto de 2021 e janeiro de 2022. A estratificação de risco foi realizada a partir do estabelecido pela Sociedade Americana de Endoscopia Digestiva (ASGE) em 2010. Resultados: foram selecionados 41 pacientes, a maior parte do sexo feminino, com média de idade de 49,6 anos, em sua maioria submetidos a colecistectomia videolaparoscópica, sem colangiografia intraoperatória. O exame de imagem mais realizado no pré-operatório foi a ultrassonografia de abdome. De acordo com os critérios da ASGE, 18 (43,9%) pacientes foram classificados como baixo risco, 19 (46,4%) foram estratificados no risco intermediário, e 4 foram de alto risco (9,7%). Conclusão: Apesar de uma amostra de tamanho limitado, evidencia-se frequência relevante do risco alto ou intermediário de coledocolitíase em portadores de colelitíase. A estratificação de risco para coledocolitíase é uma ferramenta importante a ser utilizada de rotina no pré-operatório da colecistectomia nos pacientes com diagnóstico de colelitíase.
Palavras-chave: cálculos biliares, colelitíase, coledocolitíase.
Association of Baseline Adherence to Antihypertensive Medications With Adherence After Shelter-in-Place Guidance for COVID-19 Among US Adults
Authors: Egan Brent M. , Sutherland Susan E. , Macri Cynthia I. , Deng Yi , Gerelchuluun Ariungeral , Rakotz Michael K. , Campbell Stanley V. 
Published: December 2022

ImportanceAdherence to selected antihypertensive medications (proportion of days covered [PDC]) declined after guidance to shelter in place for COVID-19.ObjectivesTo determine whether PDC for all antihypertensive medications collectively fell from the 6 months before sheltering guidance (September 15, 2019, to March 14, 2020 [baseline]) compared with the first (March 15 to June 14, 2020) and second (June 15 to September 14, 2020) 3 months of sheltering and to assess the usefulness of baseline PDC for identifying individuals at risk for declining PDC during sheltering.Design, Setting, and ParticipantsThis retrospective cohort study included a random sample of US adults obtained from EagleForce Health, a division of EagleForce Associates Inc. Approximately one-half of the adults were aged 40 to 64 years and one-half were aged 65 to 90 years, with prescription drug coverage, hypertension, and at least 1 antihypertensive medication prescription filled at a retail pharmacy during baseline.Main Outcomes and MeasuresPrescription claims were used to assess (1) PDC at baseline and changes in PDC during the first and second 3 months of sheltering and (2) the association of good (PDC ≥ 80), fair (PDC 50-79), and poor (PDC &amp;lt; 50) baseline adherence with adherence during sheltering.ResultsA total of 27 318 adults met inclusion criteria (mean [SD] age, 65.0 [11.7] years; 50.7% women). Mean PDC declined from baseline (65.6 [95% CI, 65.2-65.9]) during the first (63.4 [95% CI, 63.0-63.8]) and second (58.9 [95% CI, 58.5-59.3]) 3 months after sheltering in all adults combined (P &amp;lt; .001 for both comparisons) and both age groups separately. Good, fair, and poor baseline adherence was observed in 40.0%, 27.8%, and 32.2% of adults, respectively. During the last 3 months of sheltering, PDC declined more from baseline in those with good compared with fair baseline adherence (−13.1 [95% CI, −13.6 to −12.6] vs −8.3 [95% CI, −13.6 to −12.6]; P &amp;lt; .001), whereas mean (SD) PDC increased in those with poor baseline adherence (mean PDC, 31.6 [95% CI, 31.3-31.9] vs 34.4 [95% CI, 33.8-35.0]; P &amp;lt; .001). However, poor adherence during sheltering occurred in 1034 adults (9.5%) with good baseline adherence, 2395 (31.6%) with fair baseline adherence, and 6409 (72.9%) with poor baseline adherence.Conclusions and RelevanceThese findings suggest that individuals with poor baseline adherence are candidates for adherence-promoting interventions irrespective of sheltering guidance. Interventions to prevent poor adherence during sheltering may be more useful for individuals with fair vs good baseline adherence.
Laser scanning reveals potential underestimation of biomass carbon in temperate forest
Authors: Calders Kim , Verbeeck Hans , Burt Andrew , Origo Niall , Nightingale Joanne , Malhi Yadvinder , Wilkes Phil , Raumonen Pasi , Bunce Robert G. H. , Disney Mathias 
Published: December 2022

AbstractQuantifying climate mitigation benefits of biosphere protection or restoration requires accurate assessment of forest above‐ground biomass (AGB). This is usually estimated using tree size‐to‐mass allometric models calibrated with harvested biomass data.Using three‐dimensional laser measurements across the full range of tree size and shape in a typical UK temperate forest, we show that its AGB is 409.9 t ha−1, 1.77 times more than current allometric model estimates. This discrepancy arises partly from the bias towards small trees in allometric model calibration: 50% of AGB in this forest was in less than 7% of the largest trees (stem diameter > 53.1 cm), all larger than the trees used to calibrate the widely used allometric model.We present new empirical evidence that the fundamental assumption of tree size‐to‐mass scale‐invariance is not well‐justified for this kind of forest. This leads to substantial biases in current biomass estimates of broadleaf forests, not just in the UK, but elsewhere where the same or similar allometric models are applied, due to overdependence on non‐representative calibration data, and the departure of observed tree size‐to‐mass from simple size‐invariant relationships.We suggest that testing the underlying assumptions of allometric models more generally is an urgent priority as this has wider implications for climate mitigation through carbon sequestration. Forests currently act as a carbon sink in the UK. However, the anticipated increase in forest disturbances makes the trajectory and magnitude of this terrestrial carbon sink uncertain. We make recommendations for prioritizing measurements with better characterized uncertainty to address this issue.
A patient‐ and acquisition‐tailored injection approach for improving consistency of CT enhancement towards a target CT value in coronary CT angiography
Authors: Van Gompel Gert , Delombaerde Laurence , Zanca Federica , Tanaka Kaoru , Belsack Dries , de Mey Johan , Buls Nico 
Published: December 2022

AbstractBackgroundUnoptimized coronary CT angiography (CTA) exams typically result in a highly variable arterial enhancement (HUa) across patients. This study aimed at harmonizing arterial enhancement by implementing a patient‐, contrast‐ and kV‐tailored injection protocol.MethodsFirst, the optimal body size metric to predict HUa was identified by retrospectively analysing images of 76 patients, acquired with 70 ml contrast media (G1). Second, using phantom experiments, correction factors for the effect of kV and contrast concentration on HUa were determined. Third, a model was developed, prescribing the optimal contrast dose to be injected to obtain a diagnostically appropriate arterial target enhancement HUtarget. The model was then validated on 278 prospectively collected patients, in two groups with two different HUtarget: 525 HU (207 patients, G2A) and 425 HU (71 patients, G2B). The HUa histograms were compared among groups and to the target enhancement through their mean and standard deviation (SD) at 100 kVp reference level. Also, signal‐to‐noise ratio was obtained and compared among the groups.ResultsFat free mass (FFM) showed the highest correlation with HUa (r = 0.69). KVp correction factors ranged from 0.65 at 70 kVp to 1.22 at 140 kVp. The obtained model reduced the group heterogeneity (SD) from 101HU for reference G1 to 75HU (p < 0.001) for G2A and 68HU (p < 0.001) for G2B. The mean HUa of 506HU in G2A was slightly below HUtarget = 525HU (p = 0.01) whereas in G2B, the mean HUa of 414HU was not significantly different from HUtarget = 425HU (p = 0.54). The total iodine dose was lowered from 19.5 g‐I to 17.6 g‐I and 14.2 g‐I from G1 to G2A and G2B, on average.ConclusionA contrast injection model, based on patient's fat free mass and accounting for the contrast agent concentration and the planned CT‐scan tube voltage, harmonized arterial enhancement among patients towards a predefined target enhancement in coronary CTA scanning, without affecting the bolus timing.
Optically Excited Lasing in a Cavity‐Based, High‐Current‐Density Quantum Dot Electroluminescent Device
Authors: Ahn Namyoung , Park Young‐Shin , Livache Clément , Du Jun , Gungor Kivanc , Kim Jaehoon , Klimov Victor I. 
Published: December 2022

AbstractLaser diodes based on solution‐processable materials can benefit numerous technologies including integrated electronics and photonics, telecommunications, and medical diagnostics. An attractive system for implementing these devices is colloidal semiconductor quantum dots (QDs). The progress towards a QD laser diode has been hampered by rapid nonradiative Auger decay of optical‐gain‐active multicarrier states, fast device degradation at high current densities required for laser action, and unfavorable competition between optical gain and optical losses in a multicomponent device stack. Here we resolve some of these challenges and demonstrate optically excited lasing from fully functional high‐current density electroluminescent (EL) devices with an integrated optical resonator. This advance has become possible due to excellent optical gain properties of continuously graded QDs and a refined device architecture, which allows for highly efficient light amplification in a thin, EL‐active QD layer.
Chiral MoSe2 Nanoparticles for Ultrasensitive Monitoring of Reactive Oxygen Species In Vivo
Authors: Cao Beijia , Zhang Hongyu , Sun Maozhong , Xu Chuanlai , Kuang Hua , Xu Liguang 
Published: December 2022

AbstractReactive oxygen species (ROS) are involved in neurodegenerative diseases, cancer, and acute hepatitis, and quantification of ROS is critical for the early diagnosis of these diseases. In this work, a novel probe is developed, based on chiral molybdenum diselenide (MoSe2) nanoparticles (NPs) modified by the fluorescent molecule, cyanine 3 (Cy3). Chiral MoSe2 NPs show intensive circular dichroism (CD) signals at 390 and 550 nm, whereas the fluorescence of Cy3 at 560 nm is quenched by MoSe2 NPs. In the presence of ROS, the probe reacts with the ROS and then oxidates rapidly, resulting in decreased CD signals and the recovery of the fluorescence. Using this strategy, the limit of detection values of CD and fluorescent signals in living cells are 0.0093 nmol/106 cells and 0.024 nmol/106 cells, respectively. The high selectivity and sensitivity to ROS in complex biological environments is attributed to the Mo4+ and Se2− oxidation reactions on the surface of the NPs. Furthermore, chiral MoSe2 NPs are able to monitor the levels of ROS in vivo by the fluorescence. Collectively, this strategy offers a new approach for ROS detection and has the potential to inspire others to explore chiral nanomaterials as biosensors to investigate biological events.
Reviving Oxygen Evolution Electrocatalysis of Bulk La–Ni Intermetallics via Gaseous Hydrogen Engineering
Authors: Chen Ziliang , Yang Hongyuan , Mebs Stefan , Dau Holger , Driess Matthias , Wang Zhaowu , Kang Zhenhui , Menezes Prashanth W. 
Published: December 2022

AbstractA hydrogen processing strategy is developed to enable bulk LaNi5 to attain high activity and long‐term stability toward the electrocatalytic oxygen evolution reaction (OER). By a combination of in situ Raman and quasi in situ X‐ray absorption (XAS) spectra, secondary‐electron‐excited scanning transmission electron microscopy (STEM) patterns as well as the Rietveld method and density functional theory (DFT) calculations, it is discovered that hydrogen‐induced lattice distortion, grain refinement, and particle cracks dictate the effective reconstruction of the LaNi5 surface into a porous hetero‐nanoarchitecture composed of uniformly confined active γ‐NiOOH nanocrystals by La(OH)3 layer in the alkaline OER process. This significantly optimizes the charge transfer, structural integrity, active‐site exposure, and adsorption energy toward the reaction intermediates. Benefiting from these merits, the overpotential (322 mV) at 100 mA cm−2 for the hydrogen‐processed OER catalyst deposited on nickel foam is reduced by 104 mV as compared to the original phase. Notably, it exhibits remarkable stability for 10 days at an industrial‐grade current density of more than 560 mA cm−2 in alkaline media.
Picoperovskites: The Smallest Conceivable Isolated Halide Perovskite Structures Formed within Carbon Nanotubes
Authors: Kashtiban Reza J. , Patrick Christopher E. , Ramasse Quentin , Walton Richard I. , Sloan Jeremy 
Published: December 2022

AbstractHalide perovskite structures are revolutionizing the design of optoelectronic materials, including solar cells, light‐emitting diodes, and photovoltaics when formed at the quantum scale. Four isolated sub‐nanometer, or picoscale, halide perovskite structures formed inside ≈1.2–1.6 nm single‐walled carbon nanotubes (SWCNTs) by melt insertion from CsPbBr3 and lead‐free CsSnI3 are reported. Three directly relate to the ABX3 perovskite archetype while a fourth is a perovskite‐like lamellar structure with alternating Cs4 and polyhedral Sn4Ix layers. In ≈1.4 nm‐diameter SWCNTs, CsPbBr3 forms Cs3PbIIBr5 nanowires, one ABX3 unit cell in cross section with the Pb2+ oxidation state maintained by ordered Cs+ vacancies. Within ≈1.2 nm‐diameter SWCNTs, CsPbBr3 and CsSnI3 form inorganic‐polymer‐like bilayer structures, one‐fourth of an ABX3 unit cell in cross section with systematically reproduced ABX3 stoichiometry. Producing these smallest halide perovskite structures at their absolute synthetic cross‐sectional limit enables quantum confinement effects with first‐principles calculations demonstrating bandgap widening compared to corresponding bulk structural forms.