bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repair method for multiple adjacent small skin defects
Authors: Xiong Tingfeng , Ou Yangze , Guo Lei , Zhan Taiguo 
Published: December 2022

Abstract
Local skin flaps can be used to repair isolated defects in the skin. Numerous flap repair methods have been described, A single defect is very easy to repair, but it is not easy to repair when there are dense local defects. Guidance directing the repair of multiple adjacent skin defects is undescribed. Therefore, we propose the repair method. The adjacent skin flap is transferred and sutured on the basis of retaining all of the skin, and finally several J and W-shaped incisions can be formed. Concurrently, the complex multiple defects are stratified into simple single defect, double defect and triple defect categories. Hence this approach is termed the "JW" repair program. In this study, There were 13 patients in this group across 15 geographical locations. 4 patients were male and 9 female. Patient age ranged between 17 and 44 years old. The defect area after excision ranged from 0.3cm×0.3cm to 2.3cm×2.3cm. Defects were repaired using the "JW" repair program. 13 patients healed well, while one case suffered a small degree of skin necrosis at the tip of the flap, which was repaired. All patients achieved satisfactory appearance upon healing with no dog ear formation and no appearance deformation. The repair method therefore simplifies the complex repair of multiple adjacent skin defects and is a useful and easy-to-master technique. It can maximize the preservation of normal skin, reduce local tension, and thus reduce scarring.
Weighted asynchronous subdomain adaptation network for unsupervised fault diagnosis of bearing
Authors: Bo Lin , Sun Kong , Tang Zhi , Wei Daiping 
Published: December 2022

Abstract
The research of unsupervised cross-domain fault diagnosis for bearing is of great significance. However, there are still some problems to be solved. For example, a single predictor may not enough to acquire accurate pseudo-labels in target domain. In addition, global feature alignment may cause different subdomains of source and target domains to be too close. Finally, due to the inaccuracy of pseudo-labels, the effect of local subdomain feature alignment is also very limited. To this end, this paper proposes a weighted asynchronous subdomain adaptation network. First, according to the domain adaptation loss, a weighted integrated adaptation mechanism is constructed to get more accurate target pseudo-labels. Secondly, an asynchronous joint distribution alignment strategy is utilized to address the above mentioned problem caused by considering global alignment and local alignment separately. The proposed network is applied to perform various unsupervised cross-domain fault diagnosis tasks, and the experiment results indicate its superior diagnostic performance.
Migration and public finances in the EU*
Authors: Fiorio Carlo , Frattini Tommaso , Riganti Andrea , Christl Michael 
Published: December 2022

Abstract
We provide novel and comprehensive evidence on the net fiscal contributions of natives and migrants to the governmental budgets of EU countries. We account for income taxes and cash benefits, along with indirect taxes and in-kind benefits, which are often missing in standard datasets. We find that on average, migrants were net contributors to public finances over the period of 2014--2018 in the EU and, moreover, that they contribute approximately 1.5 thousand Euro more per capita each year than natives. We also show that this difference is partly due to the selection on characteristics that make migrants net fiscal contributors, such as demographic factors and employment probability.
Lower Rifampicin Plasma Levels are Associated with Poor Clinical Response in Abdominal Tuberculosis Patients
Authors: Ray Yogiraj , Kanswal Sunita , K Adarsh Aayilliath , Wig Naveet , Biswas Ashutosh , Ahuja Vineet , Velpandian Thirumurthy , Singh Urvashi B. 
Published: December 2022

Abstract
Purpose
The purpose of this study was to assess the Anti-tubercular treatment (ATT) levels and to determine the effect of pharmacokinetics/pharmacodynamics (Pk/Pd) of ATT on the treatment outcomes in patients with abdominal tuberculosis (ATB).
Methods
Serial measurements of ATT plasma levels were done in 45 patients with ATB at second week and at the end of first and second months of therapy. Liquid chromatography-tandem mass spectrometry was used to determine Isoniazid, Rifampicin, Pyrazinamide and Ethambutol levels in all blood samples.
Results
Low drug levels of Rifampicin was detected in 52 (38.5%) of 135 observations. Peak plasma Rifampicin level was found to be significantly lower at the end of the second month of treatment among poorly responding patients {p < 0.014 (C1hr) and 0.027(C4hr)}.
Conclusion
Low plasma levels of rifampicin were associated with a poor response to treatment in patients with ATB. Therapeutic drug monitoring can guide dose modification of ATT to achieve target concentrations in patients with ATB and facilitate optimal treatment outcomes.
Exploring the opportunities and limitations of large language models in biomedical sector
Authors: Albarqawi Ahmad 
Published: December 2022

Abstract
The development of large language models (LLMs) in recent years has shown several opportunities for improving the biomedical sector and processing unstructured electronic medical records. Despite the potential of these models, their application in the biomedical and clinical fields needs to comply with regulations and mitigate existing biases, unfactual information generation, and any potential privacy concerns. Successful implementations of LLMs need an understanding of their use cases and limitations for strategies to revolutionize the healthcare industry and operations. This research does an exhaustive assessment of the published biomedical and clinical language models to comprehend the current problems, explore the best methods for overcoming the constraints and get the models suitable for use in regulated conditions.
Tumor boundary instability induced by nutrient consumption and supply
Authors: Feng Yu , Tang Min , Xu Xiaoqian , Zhou Zhennan 
Published: December 2022

Abstract
We investigate the tumor boundary instability induced by nutrient consumption and supply based on a Hele-Shaw model. The model describes the geometric evolution of the tumor region and is derived from taking the incompressible limit of a cell density model, which leads to the pressure vanishing on the free boundary. We investigate the boundary behaviors under two different nutrient supply regimes, in vitro and in vivo, where in the former case the supply is adequate, and in the latter case the supply is deficient. Our main conclusion is that by investigating typical solutions of the tumor-nutrient model with the asymptotic analysis with respect to the domain perturbation, the tumor boundary in the in vitro regime is shown to be stable regardless of the nutrient consumption rate. However, boundary instability occurs when the nutrient consumption rate exceeds a certain threshold in the in vivo regime, and the bifurcation threshold has a monotonic dependence on the frequency of the domain perturbation.
Mathematics Subject Classification (2010). 35R35, 92C10, 70K50, 74G10
Transcriptome and Metabolome based candidate mechanism of BCR-ABL independent resistance to Olverembatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia
Authors: Yin Zhao , Liao Meiyan , Yan Rongrong , Li Guangchao , Ou Ruiming , Liu Zhi , Zhong Qi , Shen Huijuan , Zhu Yangmin , Xie Shuangfeng , Zhang Qing , Liu Shuang , Huang Jing 
Published: December 2022

Abstract
Olverembatinib represents the third-generation breakpoint cluster region protein-Abelson-murine leukemia 1 (BCR-ABL1) tyrosine kinase inhibitor (TKI) with oral bioavailability, which can be used to overcome the T315I mutation in Philadelphia chromosome-positive (Ph+) leukemia. BCR-ABL independent resistance to Olverembatinib has been reported among patients in various clinical cases. However, the mechanism of Olverembatinib resistance has rarely been reported. This study has illustrated bone marrow cell transcriptome and Metabolome profiles among Ph + acute lymphoblastic leukemias (ALL) cases pre- and post-Olverembatinib resistance. The transcriptome studies demonstrated that PI3K/AKT, purine metabolism, and other signaling pathways could play a vital role in Olverembatinib resistance. As suggested by metabolomics, Olverembatinib resistance in Ph + ALL was associated with purine metabolism alterations. Subsequently, High-Performance Liquid Chromatography (HPLC) along with Real-time Quantitative PCR (RT-qPCR) was utilized to measure purine metabolism-related mRNA levels and metabolism expression levels between Olverembatinib resistance and sensitive cell lines. Our results elucidate the mechanism of Olverembatinib resistance in Ph + ALL at transcriptome and metabolome levels, which facilitate a better understanding of Olverembatinib resistance and hence may prove crucial in identifying novel drugs to tackle this conundrum.
Mechanism of Galectin 8 protein in Aedes aegypti to survive Bt Cry11Aa
Authors: Hu Xiaohua , Huang Xianhui , Liu Jiannan , Zhao Guohui , Wu Songqing , Yu Xiaoqiang , Guan Xiong , Zhang Lingling 
Published: December 2022

Abstract
Aedes aegypti is a crucial vector of many diseases that cause millions of deaths worldwide. Cry11Aa display high toxicity to the larvae of Ae.aegypti. And the Galectins are a family of β-galactoside binding proteins that play a role in immune responses and may also affect Cry11Aa toxin activity. In our previous work, Galectin 6 and Galectin 14 were found to affect toxicity of Bt toxins. However, there are also some other galectin genes expressed in the gut of Ae.aegypti, such as Galectin 8, whose function is still not confirmed yet. In order to further understand its function and molecular mechanism, Ae.aegypti galectin 8 gene was cloned, expressed the recombinant protein and purified in this study. The bioassays results indicated that Galectin 8 is similar to Galectin 6 to reduce the toxicity of Cry11Aa. In order to determine interactions among Galectin8, Cry11Aa and toxin receptors, Octet Red System, Western blot, far-western blot assay were also performed. Octet Red System result showed that Galectin 8 could also bind to BBMVs of Ae.aegypti, but the kDa value is smaller than that of Galectin 6, indicating that Galectin 8 had a stronger binding ability to BBMVs than Galectin 6. Western blot and far-western blot analyses also demonstrated that Galectin 8 could bind to Ae.aegypti receptor ALP1 and APN2, similar to result of protein docking simulation. All of these results support the conclusion that Galectin 8 may increase block Cry11Aa from binding to ALP1 and APN2 than Galectin 6, which might decrease the toxicity of Cry11Aa for Ae.aegypti.
A Predator-Prey Model from Collective Dynamics and Self-Propelled Particles Approach
Authors: Yaya Yaya Youssouf 
Published: December 2022

Abstract
The definition and description of the dynamics of predator-prey system consists in one of the fundamental problems of the population biology. Since 1925, several models have been introduced. Although they are highly effective, most of them neglect certain relevant criteria such as the spatial and temporal distribution of the studied species. We introduced these criteria by coupling two models designed initially for collective dynamics. The first is for predators mobility, a Vicsek type model and the second is a Brownian Particle (BP) model for prey. We observed, as naturally in the classical models, periodic cycles of the density of predators and prey. In this case, the period of oscillations depends relatively on the collective dynamics parameters.
Simulation of the buffering process and carbon sink effect of karst soil on sulfuric acid rain in Guilin City, southwest China
Authors: Zhao Guangshuai , Huang Qibo , Zhu Yinian , Xu Yiling , Pu Zhenggong 
Published: December 2022

Abstract
After acid rain has settled onto the surface and has been buffered by karst soil, the capacity of acid rain to participate in carbonate rock erosion and its impact on the karst carbon sink are still unclear. To clarify the buffering process and karst carbon sink effect of karst soil with acid rain, experiments on leaching of sulfuric acid rain were conducted with pH 3.5, 4.5, and 6.5 with different karst soil thicknesses. Results have shown that the karst soil buffer to acid rain predominantly occurs in the surface soil layer. The loss of Ca2+ and Mg2+ due to acid rain H+ accounted for a small proportion of the Ca2+ and Mg2+ in the leached liquid. Soil water-soluble Ca2+, Mg2+, and soil exchangeable calcium and magnesium are the main Ca2+ and Mg2+ components in the leached liquid. They were exchanged by the H+ generated by the dissociation of soil CO2 dissolved in the soil water. A total of 74% of dissolved inorganic carbon (DIC) in the leached liquid came from soil CO2. Differences in the rainfall pH value had little effect on the sources of DIC in the leached liquid. In the karst soil area, the carbon migration process caused by rainfall is mainly dominated and driven by the soil carbon pool. Under strong acid (pH 3.5) precipitation conditions, the surface soil carbon sink was significantly higher than the deep soil carbon sink. Meanwhile, under weak acid (pH 4.5) precipitation conditions, the difference in soil carbon sink capacity of different soil thicknesses was relatively low. The capacity of the soil carbon sink had no pronounced relationship with soil depth.
Structure of plant Photosystem I in a native assembly state
Authors: Naschberger Andreas , Fadeeva Maria , Klaiman Daniel , Borovikova-Sheinker Anna , Caspy Ido , Nelson Nathan , Amunts Alexey 
Published: December 2022

Abstract

Plant Photosystem I (PSI) consists of at least 13 nuclear-encoded and four chloroplast-encoded protein subunits, acting as a sunlight-driven oxidoreductase. Here, we report the first structure of PSI assembly intermediate isolated from greening oat seedlings. The assembly state displays absence of at least eight subunits and lacks the photoreduction activity, which is attributed to an elimination of the plastocyanin (Pc) binding site, due to a missing subunit PsaF. The data shows that PsaF is a regulatory checkpoint that promotes the assembly, effectively coupling biogenesis to function.
Typhoid fever in a rare form caused by eating overripe pineapple: A Case Report and Literature Review
Authors: Bereda Gudisa 
Published: December 2022

Abstract
Typhoid fever is an acute infection caused by Salmonella typhi, especially when it is waterborne or foodborne. Overripe pineapple causes typhoid fever because overripe pineapple is a desirable host for the survival of Salmonella typhi. The importance of typhoid fever as a public health burden is reduced by early detection and appropriate antibiotic treatment. A 26-year-old black African male health care worker was admitted to the clinic on July 21, 2022, with a significant chief complaint of headache, loss of appetite, and watery diarrhea. The admitted patient presented with a two-day history of hyperthermia, headache, loss of appetite, and watery diarrhea, as well as back pain, joint weakness, and insomnia. The H antigen titer was positive, which was 1: 189 greater than the normal range and showed the past history of Salmonella typhi infection. The O antigen titer value detected was a false negative result because it was done before the 7-day onset of fever. On admission, ciprofloxacillin 500 mg was given orally twice a day for seven days to treat typhoid by inhibiting the deoxyribonucleic acid replication of Salmonella typhi by preventing Salmonella typhi deoxyribonucleic acid topoisomerase and deoxyribonucleic acid gyrase. Typhoid fever pathogenesis is based on pathogenic factors, infecting species, and host immunity. By using the agglutination biochemical test, the Widal test was able to identify the patient's bloodstream as carrying the salmonella typhi bacteria that causes typhoid fever. Due to contaminated food or unsafe drinking water sources, typhoid fever is associated with travel to developing nations.
Secrecy Performance, RF/FSO Communication,Variable Gain Relaying, α − η − μ Fading Channel,M ́alaga Fading Distribution
Authors: Mandira N. S. , Kundu M. K. , Islam S. H. , Badrudduza A. S. M. , Ansari I. S. 
Published: December 2022

Abstract
With the completion of the standardization of fifth-generation (5G) networks, the researchers have begun visioning sixth-generation (6G) networks that are predicted to be human-centric. Hence, similar to 5G networks, besides high data rates, providing secrecy and privacy will be the center of attention by the wireless research community. To support the visions beyond 5G (B5G) and 6G, in this paper we propose a secure radio frequency (RF)-free space optical (FSO) mixed framework under the attempt of wiretapping by an eavesdropper at the RF hop. We assume the RF links undergo α − η − µ fading whereas the FSO link exhibits a unified Málaga turbulence model with pointing error. The secrecy performance is evaluated by deducing expressions for three secrecy metrics i.e. average secrecy capacity, secure outage probability, and probability of non-zero secrecy capacity in terms of univariate and bivariate Meijer’s G and Fox’s H functions. We further capitalize on these expressions to demonstrate the impacts of fading, atmospheric turbulence, and pointing errors and show a comparison between two detection techniques (i.e. heterodyne detection (HD) and intensity modulation with direct detection (IM/DD)) that N. S. Mandira et al. clearly reveals better secrecy can be achieved with HD technique relative to the IM/DD method. The inclusion of generalized fading models at the RF and FSO hops offers the unification of several classical scenarios as special cases thereby exhibiting a more generic nature relative to the existing literature. Finally , all the analytical results are corroborated via Monte-Carlo simulations.
EMPIRICAL STUDY: THE ASSESSMENT OF FINANCIAL STATEMENTS IN INDONESIA ISLAMIC BANK BASED ON IFRS AND AAOIFI STANDARD
Authors: Nisa Fauzatul Laily , Rahmawati Lilik 
Published: December 2022

Abstract: This study aims to measure how far Indonesian Islamic banking adopts AAOIFI and IFRS standards in its financial reporting. This study uses the annual report of Indonesian Islamic banks in the period 2014-2018 obtained from 5 Islamic banks in Indonesia compiled from the official website of the five banks that were sampled. This research uses a quantitative approach by using a Content Analysis method. This study's results indicate that Indonesian Islamic banking is more inclined to adopt IFRS standards in its annual financial reports (annual report). It can be proven by the large number of percentages of Islamic banking that predominantly meet the total items selected as IFRS standards in its financial statements, compared to the percentage Islamic banking that matches the total items selected as AAOIFI standards.

Keywords: financial statements; Islamic banks; IFRS; AAOIFI
Risk factors affecting the occurrence of urinary schistosomiasis and urinary tract infections in some communities of Ondo State, Nigeria
Authors: Kone Kikelomo Jennifer , Onifade Anthony Kayode , Dada Ebenezer Oluyemi 
Published: December 2022

Abstract
Schistosomiasis is one of the neglected tropical diseases, affecting about 240 million people worldwide. Urinary schistosomiasis (US) is a chronic and debilitating disease caused by blood flukes, Schistosoma haematobium, and people with US are vulnerable to secondary infections caused by bacteria. The study was designed to evaluate the risk factors involved in US and urinary tract infection (UTI) in parts of Ondo State, Nigeria. The study areas were rural communities known to be endemic for schistosomiasis, with farming as their major occupation and they depend solely on the use of the infected rivers for their day to day activities. Structured questionnaires were administered to obtain information concerning the infections. Five hundred and nine community dwellers participated in the study. The results showed that schistosomiasis was significant for gender and age (X2(1) = 23.934, p = 0.000) and (X2(7) = 85.991, p = 0.000), respectively, while UTI was not significant for age and gender. The study revealed that gender, age, contact with infected water, and duration spent in the water were risk factors associated with the development of schistosomiasis and UTI in the communities.
An inverse problem for modeling open channel flow with movable bed
Authors: Roushangar Kiyoumars , Ghasempour Roghayeh , Azamathulla Hazi Mohammad 
Published: December 2022

Abstract
In this research, an explicit finite difference two steps scheme developed by Richtmyer is presented for simulation of 1D steady/unsteady flow and bed morphology in alluvial channels. Some laboratory experiments were performed in a mobile-bed flume for both of steady an unsteady flow to validate the proposed model. For improving the simulation, first, the role of sediment transport formulas, coupled–uncoupled approaches and simplification in the mass continuity equation are investigated. Comparisons between experimental data and model performance highlight the advantage of coupled method over the uncoupled method, domain role of sediment transport model in the bed morphological simulation and inaccuracy of aggradation processes due to simplifying the mixture continuity equation. Second, the importance of changing alluvial roughness is established by testing the model with calibrated and optimized friction factors. The inverse problem of estimating alluvial flow roughness is solved using a genetic algorithm (GA) optimization model coupled with alluvial flow model. The study demonstrates that the application of GA in the search for optimal values of roughness coefficients can significantly reduce computational errors and improve the computed water stage hydrographs. Role of the choice of the objective function is also mentioned.