bluuebunny/crossref_metadata_2025_split huggingface dataset:
Team science: A syllabus for success on big projects
Authors: Peterson Delaney M. , Flynn Sarah M. , Lanfear Riley S. , Smith Chelsea , Swenson Logan J. , Belskis Alice M. , Cook Stephen C. , Wheeler Christopher T. , Wilhelm Jessica F. , Burgin Amy J. 
Published: July 2023

AbstractInterdisciplinary teams are on the rise as scientists attempt to address complex environmental issues. While the benefits of team science approaches are clear, researchers often struggle with its implementation, particularly for new team members. The challenges of large projects often weigh on the most vulnerable members of a team: trainees, including undergraduate students, graduate students, and post‐doctoral researchers. Trainees on big projects have to navigate their role on the team, with learning project policies, procedures, and goals, all while also training in key scientific tasks such as co‐authoring papers. To address these challenges, we created and participated in a project‐specific, graduate‐level team science course. The purposes of this course were to: (1) introduce students to the goals of the project, (2) build trainees' understanding of how big projects operate, and (3) allow trainees to explore how their research interests dovetailed with the overall project. Additionally, trainees received training regarding: (1) diversity, equity & inclusion, (2) giving and receiving feedback, and (3) effective communication. Onboarding through the team science course cultivated psychological safety and a collaborative student community across disciplines and institutions. Thus, we recommend a team science course for onboarding students to big projects to help students establish the skills necessary for collaborative research. Project‐based team science classes can benefit student advancement, enhance the productivity of the project, and accelerate the discovery of solutions to ecological issues by building community, establishing a shared project vocabulary, and building a workforce with collaborative skills to better answer ecological research questions.
Phylogeography and molecular diversity of two highly abundant Themisto amphipod species in a rapidly changing Arctic Ocean
Authors: Murray Ayla , Præbel Kim , Desiderato Andrea , Auel Holger , Havermans Charlotte 
Published: July 2023

AbstractRapid warming in the Arctic is drastically impacting marine ecosystems, affecting species communities and food‐web structure. Pelagic Themisto amphipods are a major component of the Arctic zooplankton community and represent a key link between secondary producers and marine vertebrates at higher trophic levels. Two co‐existing species dominate in the region: the larger Themisto libellula, considered a true polar species and the smaller Themisto abyssorum, a sub‐Arctic, boreal‐Atlantic species. Recent changes in abundance and distribution ranges have been detected in both species, likely due to the Atlantification of the Arctic. The ecology and genetic structure of these species are understudied, despite their high biomass and importance in the food web. For both species, we assessed genetic diversity, patterns of spatial genetic structure and demographic history using samples from the Greenland shelf, Fram Strait and Svalbard. This was achieved by analysing variation on the mitochondrial cytochrome c oxidase subunit 1 gene (mtCOI). The results revealed contrasting levels of mtCOI diversity: low levels in T. libellula and high levels in T. abyssorum. A lack of spatial genetic structure and a high degree of genetic connectivity were detected in both species in the study region. These patterns of diversity are potentially linked to the impacts of the Last Glacial Maximum. T. libellula populations may have been isolated in glacial refugia, undergoing gene flow restriction and vicariant effects, followed by a population expansion after deglaciation. Whereas T. abyssorum likely maintained a stable, widely distributed metapopulation further south, explaining the high diversity and connectivity. This study provides new data on the phylogeography of two ecologically important species, which can contribute to predicting how zooplankton communities and food‐web structure will manifest in the rapidly changing Arctic.
Host infection and disease‐induced mortality modify species contributions to the environmental reservoir
Authors: Laggan Nichole A. , Parise Katy L. , White J. Paul , Kaarakka Heather M. , Redell Jennifer A. , DePue John E. , Scullon William H. , Kath Joseph , Foster Jeffrey T. , Kilpatrick A. Marm , Langwig Kate E. , Hoyt Joseph R. 
Published: July 2023

AbstractEnvironmental pathogen reservoirs exist for many globally important diseases and can fuel epidemics, influence pathogen evolution, and increase the threat of host extinction. Species composition can be an important factor that shapes reservoir dynamics and ultimately determines the outcome of a disease outbreak. However, disease‐induced mortality can change species communities, indicating that species responsible for environmental reservoir maintenance may change over time. Here we examine the reservoir dynamics of Pseudogymnoascus destructans, the fungal pathogen that causes white‐nose syndrome in bats. We quantified changes in pathogen shedding, infection prevalence and intensity, host abundance, and the subsequent propagule pressure imposed by each species over time. We find that highly shedding species are important during pathogen invasion, but contribute less over time to environmental contamination as they also suffer the greatest declines. Less infected species remain more abundant, resulting in equivalent or higher propagule pressure. More broadly, we demonstrate that high infection intensity and subsequent mortality during disease progression can reduce the contributions of high‐shedding species to long‐term pathogen maintenance.
A nationwide study of temporal trends of cause‐specific hospital readmissions in patients with heart failure
Authors: Kontogeorgos Silvana , Sandström Tatiana Zverkova , Rosengren Annika , Fu Michael 
Published: July 2023

AbstractAimsThe impact of hospital readmissions on the outcomes of heart failure (HF) patients is well known. However, data on temporal trends of cause‐specific hospital readmissions in these patients are limited.Methods and resultsFrom 1987 to 2014, we identified and followed up for 1 year 608 135 patients ≥18 years hospitalized with HF according to the International Classification of Diseases (ICD) 9 and 10 from the National Inpatient Register. Readmissions for cardiovascular (CVD) and non‐CVD causes and co‐morbidities were defined according to ICD‐9 and ICD‐10 codes. We analysed trends in the incidence rate of readmissions, the median time to the first rehospitalization, and the time to readmission, stratified by sex, age groups and cause of rehospitalization using linear regression. During our study, 1 year all‐cause mortality decreased (β = −4.93, P < 0.0001), but the incidence rate of readmissions per 1000 person‐years remained unchanged. The readmission rate for CVD causes decreased; in contrast, the readmission rate increased across all age and sex groups for non‐CVD causes. Analysing the patients by study periods (1987–1997, 1998–2007 and 2008–2014), CVD and non‐CVD co‐morbidities had a statistically significant increasing trend (P < 0.001). The median time in hospital decreased and the median time to the first readmission were almost unchanged.ConclusionsContrary to a declining mortality rate, the incidence rate of readmissions saw no change, possibly because of divergent trends in cause‐specific readmissions. An increasing rate of readmissions for non‐CVD causes underscores the importance of optimising multimorbidity management to reduce the risk of readmissions in patients with HF.
The association between erector spinae muscle content and chronic heart failure and its severity
Authors: Zhang Hao , Hu Weiwei , Yuan Mengxuan , Lu Dasheng , Gao Yang , Dai Qiming 
Published: July 2023

AbstractAimsPrevious studies have shown a significant reduction in skeletal muscle content in patients with chronic heart failure (CHF). The present study focused on the erector spinae muscle (ESM) to determine whether ESM content is associated with the development and severity of CHF.Methods and resultsA total of 652 patients were included in this trial for the study. According to the diagnostic criteria of CHF, 652 patients were divided into two groups, namely, the control group (268 patients) and the CHF group (384 patients). Meanwhile, to assess whether the ESM is associated with the severity of CHF, patients in the CHF group were divided into two groups according to left ventricular ejection fraction (LVEF) values: heart failure with preserved ejection fraction (HFpEF, LVEF ≥50%, 256 patients) and heart failure with reduced ejection fraction (HFrEF, LVEF ≤40%, 68 patients). Receiver operating curve analysis was performed to assess whether ESM content could predict CHF and determine its severity. Compared with the control group, the patients in the CHF group were older, the prevalence of coronary heart disease (CHD) and atrial fibrillation was higher, the colour ultrasound results showed that LVEF decreased significantly, and the left ventricular end‐diastolic internal diameter and left ventricular end‐systolic internal diameter increased significantly. Besides, patients in the CHF group had significantly lower ESM content, and ESM is an independent predictor of heart failure, with an odds ratio of 0.713 (CHF group vs. control group, 95% confidence interval 0.626–0.811, P < 0.001). Compared with the HFpEF group, the HFrEF group has a lower prevalence of CHD, LVEF decreased significantly, the left ventricular end‐diastolic internal diameter and left ventricular end‐systolic internal diameter increased significantly, also patients in the HFrEF group had significantly lower ESM content compared with patients in the HFpEF group, and ESM is an independent predictor of the severity of heart failure, with an odds ratio of 0.514 (HFrEF group vs. HFpEF group, 95% confidence interval (0.418–0.633, P < 0.05). The results of receiver operating curve analysis showed that the sensitivity and specificity of ESM content for the diagnosis of CHF were 65.6% and 71.6%, respectively, while the sensitivity and specificity of ESM content for predicting the severity of CHF were 47.1% and 89.1%, respectively.ConclusionsThe ESM is of great value in predicting the onset and severity of CHF.
Synthesis, Characterization, and Catalytic Activity of a Cubic [Mo3S4Pd] Cluster Bearing Bulky Cyclopentadienyl Ligands
Authors: Izu Hitoshi , Bhave Devashish Girish , Matsuoka Yuto , Sameera W. M. C. , Tanifuji Kazuki , Ohki Yasuhiro 
Published: July 2023

AbstractA cubic metal‐sulfur cluster containing three Mo ions and a Pd ion, [CpSiEt33Mo3S4Pd]Cl (Mo3Pd, CpSiEt3=C5Me4SiEt3), was synthesized by the incorporation of the Pd ion into a Mo3S4 cluster [CpSiEt33Mo3S4] (Mo3). Mo3Pd was characterized by 1H NMR, UV‐vis, X‐ray crystallography, and cyclic voltammetry measurements. The electrochemical measurements demonstrated reversible one‐ and two‐electron reduction processes for Mo3Pd, which suggested potential catalytic activity for two‐electron substrate reductions such as hydrogen evolution reaction. Controlled potential electrolysis in the presence of Mo3Pd and trifluoroethanol in THF solvent displayed H2 formation with a constant current over 60 min. The amount of generated H2 by Mo3Pd was two times higher than Mo3, indicating the catalytic activity facilitated by the Pd center. The mechanism of the catalytic cycle was determined by density functional theory.
Single‐Source Precursors for the Chemical Vapor Deposition of Iron Germanides
Authors: Büttner Thomas , Janka Oliver , Huch Volker , Dhara Debabrata , Jana Anukul , Scheschkewitz David 
Published: July 2023

AbstractBinary iron‐germanium phases are promising materials in magnetoelectric, spintronic or data storage applications due to their unique magnetic properties. Previous protocols for preparation of FexGey thin films and nanostructures typically involve harsh conditions and are challenging in terms of phase composition and homogeneity. Herein, we report the first example of single source chemical vapor deposition (CVD) of FexGey films. The appreciable volatility of [Ge[Fe2(CO)8]2], [Cl2GeFe(CO)4]2 and Me₂iPr₂NHC ⋅ GeCl2 ⋅ Fe(CO)4 allowed for their application as precursors under standard CVD conditions (Me₂iPr₂NHC=1,3‐diisopropoyl‐4,5‐dimethylimidazol‐2‐ylidene). The thermal decomposition products of the precursors were characterized by TGA and powder XRD. Deposition experiments in a cold‐wall CVD reactor resulted in dense films of FexGey. During the optimization of synthetic conditions for precursor preparation the new iron‐germanium cluster Cl2Ge[Fe2(CO)8]Ge[Fe2(CO)8] was obtained in experiments with a higher stoichiometric ratio of GeCl2 ⋅ 1,4‐dioxane vs. Fe2(CO)9.
Julia‐Kocienski Olefination in the Synthesis of Trisubstituted Alkenes: Recent Progress
Authors: Ouzounthanasis Konstantinos A. , Rizos Stergios R. , Koumbis Alexandros E. 
Published: July 2023

AbstractJulia‐Kocienski olefination, a coupling reaction between a carbonyl component and a sulfone partner, has emerged as a powerful synthetic tool in the preparation of several organic compounds. A number of interesting examples involving particularly the preparation of trisubstituted alkenes along with important observations regarding the stereoselectivity of those reactions have been recently reported. This reviewing work covers the literature for the period 2016–2022 and describes in a comprehensive way the progress and developments of Julia‐Kocienski olefination application in the synthesis of trisubstituted alkenes which serve as precursors of natural products and their analogs as well of pharmaceutically interesting/biologically important compounds. Moreover, key methodology results dealing with the investigation of the optimum conditions and stereoselectivities and new modifications and approaches are discussed.
Seismic control of multidegree‐of‐freedom structures using a concentratedly arranged tuned viscous mass damper
Authors: Kang Jianfei , Ikago Kohju 
Published: July 2023

AbstractConnecting a flexible supporting element to an inerter arranged in parallel with a viscous element yields a tuned‐mass damper‐like system, designated as a tuned viscous mass damper (TVMD). The advantage of a TVMD is that it exploits the flexibility of the supporting member, which is usually considered to compromise the energy‐dissipating performance, and the inerter and soft spring form a supplemental oscillator to enhance the damping performance with resonance to the primary structure. The fixed‐point method for the optimal design of a single‐degree‐of‐freedom structure containing a TVMD is further expanded to a multidegree‐of‐freedom structure, in which a TVMD is arranged concentratedly. Furthermore, approximated closed‐form formulae for a concentratedly arranged TVMD are derived under the assumption that the primary structure is undamped, remains in an elastic range, and the target mode dominates the response of the structure. An analytical example illustrates that installing a TVMD spanning three stories in a concentrated manner based on the proposed design methods ensures the efficiency of the damping system, which demonstrates a damping effect similar to that of stiffness‐proportionally distributed TVMDs with less demand for inertance and total control force, thus resulting in a lower cost.
Evaluation of baking qualities, functional and physicochemical properties of wheat supplemented with cassava and mung bean flour blends for bread making
Authors: Anosike Francis C. , Chinwendu Okwuowulu R. , Nnaemeka Nwigboji A. , Nneka Mofunanya G. , Inyang Paul , Ikechukwu Chinaka , Blessing Onye‐Chinedu C. , Onyeji Gertrude N. , Prince‐Osuji Emeka C. 
Published: July 2023

AbstractThe present study evaluated the baking qualities and physicochemical properties of bread produced from wheat flour supplemented with cassava and mung bean flour blends at different levels of inclusion to assess its suitability to be used in bread production. Standard methods were used to carry out the baking qualities and physicochemical properties of the flour blends while 20 semitrained panelists were recruited for the sensory evaluation. The result showed that the gluten content of the flour blends ranged from 3.61% to 24.19%. Sample A (90% wheat:5% cassava:5% mung bean) flour blend had the highest gluten content while sample D (60% wheat:20% cassava:20% mung bean) flour blend recorded the lowest value of gluten content. The viscosity of the flour blends was found to decrease significantly (p ≥ 0.05) with an increase in temperature while the functional properties of the flour blends and physical properties of the bread varied among samples. Sample B (80% wheat:5% cassava:5% mung bean) was found to be highest in bulk density, loaf volume, and specific volume with values 0.73 g/mL, 7.86 cm3, and 0.05 cm3/g, respectively, with enhanced baking quality. Results of the chemical composition showed that fiber and protein content increased with an increase in substitution levels. Sample D had the highest value 0.43% and 27.65% while sample E (100% wheat) had the lowest value 0.38% and 12.60% for fiber and protein content respectively. Carbohydrate content decreased with an increase in substitution levels. Sample E had the highest value 48.88% while sample D had the lowest value 25.32%. Values for moisture, ash, fat, crude fiber, and energy content varied among samples and substitution levels. Sensory evaluation of the various attributes rated on 9 points hedonic scale showed a decrease in the mean score as the level of substitution increased. Sample E was rated high in all sensory attributes and was also found to be significantly different (p ≥ 0.05) among samples although in general acceptability sample E was found to be the same as sample A. The result showed that bread made from 90% wheat:5% cassava:5% mung bean flour blend (sample A) compare favorably with bread made from 100% wheat flour (control) but in baking quality sample B was found to be the best.
High‐order curvilinear Lagrangian finite element methods for shallow water hydrodynamics
Authors: Zhang Jiexing , Han Ruoyu , Ni Guoxi 
Published: July 2023

AbstractWe propose a high‐order curvilinear Lagrangian finite element method for shallow water hydrodynamics. This method falls into the high‐order Lagrangian framework using curvilinear finite elements. We discretize the position and velocity in continuous finite element spaces. The high‐order finite element basis functions are defined on curvilinear meshes and can be obtained through a high‐order parametric mapping from a reference element. Considering the variational formulation of momentum conservation, the global mass matrix is independent of time due to the use of moving finite element basis functions. The mass conservation is discretized in a pointwise manner which is referred to as strong mass conservation. A tensor artificial viscosity is introduced to deal with shocks, meanwhile preserving the symmetry property of solutions for symmetric flows. The generic explicit Runge–Kutta method could be adopted to achieve high‐order time integration. Several numerical experiments verify the high‐order accuracy and demonstrate good performances of using high‐order curvilinear elements.
Prophylactic effect of chronic immunosuppression in a mouse model of CSF‐1 receptor‐related leukoencephalopathy
Authors: Chitu Violeta , Biundo Fabrizio , Oppong‐Asare Jude , Gökhan Şölen , Aguilan Jennifer T. , Dulski Jaroslaw , Wszolek Zbignew K. , Sidoli Simone , Stanley E. Richard 
Published: July 2023

AbstractMutations leading to colony‐stimulating factor‐1 receptor (CSF‐1R) loss‐of‐function or haploinsufficiency cause CSF1R‐related leukoencephalopathy (CRL), an adult‐onset disease characterized by loss of myelin and neurodegeneration, for which there is no effective therapy. Symptom onset usually occurs in the fourth decade of life and the penetrance of disease in carriers is high. However, familial studies have identified a few carriers of pathogenic CSF1R mutations that remain asymptomatic even in their seventh decade of life, raising the possibility that the development and severity of disease might be influenced by environmental factors. Here we report new cases in which long‐term glucocorticoid treatment is associated with asymptomatic status in elder carriers of pathogenic CSF‐1R mutations. The main objective of the present study was to investigate the link between chronic immunosuppression initiated pre‐symptomatically and resistance to the development of symptomatic CRL, in the Csf1r+/− mouse model. We show that chronic prednisone administration prevents the development of memory, motor coordination and social interaction deficits, as well as the demyelination, neurodegeneration and microgliosis associated with these deficits. These findings are in agreement with the preliminary clinical observations and support the concept that pre‐symptomatic immunosuppression is protective in patients carrying pathogenic CSF1R variants associated with CRL. Proteomic analysis of microglia and oligodendrocytes indicates that prednisone suppresses processes involved in microglial activation and alleviates senescence and improves fitness of oligodendrocytes. This analysis also identifies new potential targets for therapeutic intervention.
An evaluation of negative reinforcement to increase self‐feeding and self‐drinking for children with feeding disorders
Authors: Haney Sarah D. , Ibañez Vivian F. , Kirkwood Caitlin A. , Piazza Cathleen C. 
Published: July 2023

AbstractSelf‐feeding with utensils represents an important step in a child's progression toward age‐typical eating and emerges in the absence of intervention for most children. In contrast, children with feeding disorders may lack the skill or motivation to self‐feed, which impedes progress toward age‐typical eating. In the current study, experimenters used a multielement design to evaluate negative reinforcement in the form of meal termination to transition six participants with a feeding disorder from caregiver‐fed to self‐fed bites and drinks. Caregivers conducted meals in which they fed the participant or prompted them to self‐feed. During self‐fed meal‐termination sessions, participants had the opportunity to end the meal contingent on self‐feeding the presented bite(s) or drink(s). Self‐feeding increased during meal‐termination sessions for all participants. The experimenters discuss these results relative to their potential to inform interventions for children with feeding disorders that progress the child toward age‐typical eating.