bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conversion to mTOR Inhibitor to Reduce the Incidence of Cytomegalovirus Recurrence in Kidney Transplant Recipients Receiving Preemptive Treatment: A Prospective, Randomized Trial
Authors: Viana Laila Almeida , Cristelli Marina Pontello , Basso Geovana , Santos Daniel Wagner , Dantas Marcus Taver Costa , Dreige Yasmim Cardoso , Requião Moura Lucio R. , Nakamura Monica Rika , Medina-Pestana Jose , Tedesco-Silva Helio 
Published: April 2023

Background.
Although mammalian target of rapamycin inhibitors (mTORi) are associated with a lower incidence of the first episode of cytomegalovirus (CMV) infection/disease in kidney transplant recipients receiving calcineurin inhibitors (CNIs), the efficacy and safety of the conversion from the antimetabolite to an mTORi for the prevention of CMV recurrence are unknown.

Methods.
In this single-center prospective randomized trial, low-immunological-risk, CMV-positive kidney transplant recipients receiving preemptive therapy were randomized to be converted (sirolimus [SRL]) or not (control [CTR]) immediately after the treatment of the first episode of CMV infection/disease and were followed for 12 mo. A sample size of 72 patients was calculated to demonstrate a 75% reduction in the incidence of CMV recurrence (80% power, 95% confidence level).

Results.
Of 3247 adult kidney transplants performed between September 13, 2015, and May 7, 2019, 1309 (40%) were treated for the first CMV infection/disease, and 72 were randomized (35 SRL and 37 CTR). In the SRL group, there were no episodes of CMV recurrence, compared with 16 patients in the CTR group (0% versus 43%; P < 0.0001). Four patients had a second and 1 a third recurrent CMV event. Three of them were converted to SRL and did not develop any further CMV events. There were no differences in the incidence of acute rejection, drug discontinuation, kidney function, and patient and graft survival at 12 mo.

Conclusions.
These data suggest that, in CMV-positive kidney transplant recipients, the conversion from an antiproliferative drug to SRL after the first CMV episode is an effective and safe strategy for recurrent episodes.
Efficacy of Autologous Skeletal Myoblast Cell Sheet Transplantation for Liver Regeneration in Liver Failure
Authors: Toya Keisuke , Tomimaru Yoshito , Kobayashi Shogo , Harada Akima , Sasaki Kazuki , Iwagami Yoshifumi , Yamada Daisaku , Noda Takehiro , Takahashi Hidenori , Kado Takeshi , Imamura Hiroki , Takaichi Shohei , Chijimatsu Ryota , Asaoka Tadafumi , Tanemura Masahiro , Miyagawa Shigeru , Doki Yuichiro , Eguchi Hidetoshi 
Published: April 2023

Background.
No effective therapies have yet been established for liver regeneration in liver failure. Autologous skeletal myoblast cell sheet transplantation has been proven to improve cardiac function in patients with heart failure, and one of the mechanisms has been reported to be a paracrine effect by various growth factors associated with liver regeneration. Therefore, the present study focused on the effect of myoblast cells on liver regeneration in vitro and in vivo.

Methods.
We assessed the effect of myoblast cells on the cells comprising the liver in vitro in association with liver regeneration. In addition, we examined in vivo effect of skeletal myoblast cell sheet transplantation in C57/BL/6 mouse models of liver failure, such as liver fibrosis induced by thioacetamide and hepatectomy.

Results.
In vitro, the myoblast cells exhibited a capacity to promote the proliferation of hepatic epithelial cells and the angiogenesis of liver sinusoidal endothelial cells, and suppress the activation of hepatic stellate cells. In vivo, sheet transplantation significantly suppressed liver fibrosis in the induced liver fibrosis model and accelerated liver regeneration in the hepatectomy model.

Conclusions.
Autologous skeletal myoblast cell sheet transplantation significantly improved the liver failure in the in vitro and in vivo models. Sheet transplantation is expected to have the potential to be a clinically therapeutic option for liver regeneration in liver failure.
Effect of Serious Mental Illness on Surgical Consultation and Operative Management of Older Adults with Acute Biliary Disease: A Nationwide Study
Authors: Brown Danielle E , Finn Caitlin B , Roberts Sanford E , Rosen Claire B , Kaufman Elinore J , Wirtalla Chris , Kelz Rachel 
Published: April 2023

Introduction:
Mental illness is associated with worse outcomes after emergency general surgery. To understand how pre-operative processes of care may influence disparate outcomes, we examined rates of surgical consultation, treatment, and operative approach between older adults with and without serious mental illness (SMI).

Methods:
We performed a nationwide, retrospective cohort study of Medicare beneficiaries aged ≥65.5 years hospitalized via the emergency department for acute cholecystitis or biliary colic. SMI was defined as schizophrenia-spectrum, mood, and/or anxiety disorders. The primary outcome was surgical consultation. Secondary outcomes included operative treatment and surgical approach (laparoscopic versus open). Multivariable logistic regression was used to examine outcomes with adjustment for potential confounders related to patient demographics, co-morbidities, and rates of imaging.

Results:
Of 85,943 included older adults, 19,549 (22.7%) had SMI. Prior to adjustment, patients with SMI had lower rates of surgical consultation (78.6% vs. 80.2%, p<0.001) and operative treatment (68.2% vs. 71.7%, p<0.001), but no significant difference regarding laparoscopic approach (92.0% vs. 92.1%, p=0.805). In multivariable regression models with adjustment for confounders, there was no difference in odds of receiving a surgical consultation [OR 0.98 (95% CI 0.93-1.03)] or undergoing operative treatment [OR 0.98 (95% CI 0.93-1.03)] for patients with SMI compared to those without SMI.

Conclusions:
Older adults with SMI had similar odds of receiving surgical consultation and operative treatment as those without SMI. As such, differences in processes of care that result in SMI-related disparities likely occur before or after the point of surgical consultation in this universally insured patient population.
DNA-targeting and cell-penetrating antibody-drug conjugate
Authors: Shirali Anupama , Dubljevic Valentina , Cao Fei , Nishimura Robert N. , Ebens Allen , Campbell James A. , Hansen James E. 
Published: April 2023

AbstractDNA released by dying cancer cells offers a tumor targeting strategy that is independent of specific cell surface antigens. Anti-DNA antibodies preferentially localize to tumor microenvironments enriched in extracellular DNA and can penetrate live tumor cells through nucleoside salvage pathways. Nuclear-localizing variants of anti-DNA antibodies cause DNA damage and selectively kill cancer cells with defects in DNA repair. Here we show that an optimized full-length IgG1 anti-DNA antibody penetrates live cells and is synthetically lethal to BRCA2-deficient tumors but has minimal effect of DNA repair-proficient tumors. Linkage of the antibody to the anti-mitotic drug monomethyl auristatin E yields a DNA-targeting and cell-penetrating anti-DNA antibody-drug conjugate (ADC) that is well tolerated in mice and highly toxic to tumors with intact DNA repair. This work provides proof-of-concept for the novel use of an anti-DNA antibody as the backbone of a DNA-targeting, cell-penetrating ADC that can impact tumors that otherwise lack specifically targetable surface antigens.Statement of significanceA strategy for targeting tumors that lack specific surface antigens is revealed by an anti-DNA antibody-drug conjugate that localizes to tumor microenvironments enriched in DNA and penetrates cells through nucleoside salvage pathways.
Whole-brain mapping reveals the divergent impact of ketamine on the dopamine system
Authors: Datta Malika S. , Chen Yannan , Chauhan Shradha , Zhang Jing , De La Cruz Estanislao Daniel , Gong Cheng , Tomer Raju 
Published: April 2023

AbstractKetamine is a multifunctional drug with clinical applications as an anesthetic, as a pain management medication and as a transformative fast-acting antidepressant. It is also abused as a recreational drug due to its dissociative property. Recent studies in rodents are revealing the neuronal mechanisms that mediate the complex actions of ketamine, however, its long-term impact due to prolonged exposure remains much less understood with profound scientific and clinical implications. Here, we develop and utilize a high-resolution whole-brain phenotyping approach to show that repeated ketamine administration leads to a dosage-dependent decrease of dopamine (DA) neurons in the behavior state-related midbrain regions and, conversely, an increase within the hypothalamus. Congruently, we show divergently altered innervations of prefrontal cortex, striatum, and sensory areas. Further, we present supporting data for the post-transcriptional regulation of ketamine-induced structural plasticity. Overall, through an unbiased whole-brain analysis, we reveal the divergent brain-wide impact of chronic ketamine exposure on the association and sensory pathways.
Organizational culture and innovation: exploring the “black box”
Authors: Vargas-Halabi Tomás , Yagüe-Perales Rosa Maria 
Published: April 2023

PurposeThis research aimed to conceptualize organizations as open and purposeful systems to study how organizational culture (OC) influences firms' Innovative Performance (IP). The authors proposed goal setting and internal integration/external adaptation paradox as central to explaining OC's mediating and suppressing effects on IP.Design/methodology/approachThe authors collected data from 372 Costa Rican organizations and analyzed them with structural equations. This research used the Denison Model instead of the usual typology-based approaches.FindingsThe mission had a direct and high impact on IP. The mediated effect via adaptability was also elevated, as well as the suppressor effect through consistency. There was no effect on IP of involvement. According to these results, the Open and Rational Systems Framework emerge as the main theoretical explanatory concepts.Originality/valueDisaggregating the OC through a performance-oriented dimensional model makes it possible to study the dynamics between the elements that compound it and facilitate integrating these findings with other research streams.
Extra-role behaviour of non-family employees in private family firms through job crafting: mediating role of workplace flourishing
Authors: Razzak Mohammad Rezaur 
Published: April 2023

PurposeThe family business literature indicates that non-family employees (NFEs) working in private family firms often feel marginalized effecting their ability to flourish at work and contribute to the organization beyond their defined job roles. Therefore, this study examines whether enabling NFEs to craft their own jobs, leads them to reappraise their position in the organization, thus influencing workplace flourishing (WF) and supervisor-assessed extra-role behaviour (ERB).Design/methodology/approachBuilding on the Conservation of Resources theory, a set of hypotheses is posited relating the three dimensions of job crafting (resource seeking, challenge seeking and job demand reduction) to ERB, through WF as a mediator. The hypotheses are tested through matched employee–supervisor data collected from 256 individuals working in private family firms, where 232 were NFEs while 24 individuals were supervisors.FindingsThe result generated through PLS-SEM indicates that all three dimensions of job crafting have a positive influence on WF. In the case of direct effect on ERB, only the direct relationship between challenge seeking and ERB was significant. However, the relationships between all three dimensions of job crafting and ERB became positive and significant through WF as mediator.Research limitations/implicationsThe implications of this study is that merely empowering NFEs to craft their own jobs may not lead them to contribute to the organization beyond their routine tasks. However, if they appraise such empowerment as a resource gain sufficient enough for them to feel that there are flourishing at the workplace, and then it is likely to influence their commitment to the organization to exhibit significant ERB. The study however is limited, as other potential exogenous variables that influence ERB were not considered.Practical implicationsThis study presents evidence for family business owners and managers to provide the pertinent resource support to their NFEs, so that they can flourish and contribute to the employer.Originality/valueThe current study contributes to the under-researched and fragmented literature on NFEs working in family firms. Furthermore, this appears to be among the first study that looks into workplace flourishing and ERB among NFEs in the realm of family business.
Corporate social responsibility and dividend policy in India
Authors: Dahiya Monika , Singh Shveta , Chaudhry Neeru 
Published: April 2023

PurposeThe study investigates the relationship between corporate social responsibility (CSR) and dividend policy in the context of Indian firms, as well as how regulatory interventions in the form of mandated CSR can moderate this relationship.Design/methodology/approachA sample of the largest 500 companies listed on the National Stock Exchange from 2008 to 2019 is used in the study. The authors employ the system generalized method of moments since this estimation technique yields accurate and consistent findings in a dynamic panel data setting.FindingsThe authors find that CSR is positively associated with dividend payments. Increased incomes and lower financial constraints are the likely factors causing this relationship. Additional analysis suggests that the positive relationship is stronger for mature firms and for firms with higher information asymmetry. Financial reporting quality works in tandem with CSR to boost dividends. Regulatory interventions in the form of mandated CSR weaken the relationship. Finally, the speed of adjustment of dividends is relatively faster for socially responsible firms.Practical implicationsThe positive association between CSR and dividends suggests that the interest of shareholders and other non-financial stakeholders can be reconciled. Additionally, businesses should attempt to strategically implement their CSR plans in accordance with the requirements of Section 135 of the Companies Act, 2013 to avoid any unfavourable moderating effects of the legislation. The results also show that CSR disclosures complement rather than serve as a substitute for financial disclosures.Originality/valueThe study is the first to evaluate the relationship between CSR and dividends in the context of India, which is a pioneer in passing legislation that mandates CSR for firms surpassing a threshold. The authors also identify financial constraints as a channel through which CSR affects dividends.
Mesopredator release among invasive predators: Controlling red foxes can increase feral cat density and alter their behaviour
Authors: Rees Matthew W. , Pascoe Jack H. , Le Pla Mark , Robley Alan , Birnbaum Emma K. , Wintle Brendan A. , Hradsky Bronwyn A. 
Published: April 2023

Abstract1. The mesopredator release theory predicts that the density of subordinate predators will increase as dominant predators decline. Persistent debate around mesopredator release in part reflects the lack of robust, replicated experiments that test this theory, and the use of population indices that confound changes in mesopredator density and detectability. This uncertainty has immediate impacts for conservationists who are faced with managing sympatric invasive predators.2. We used replicated experimental designs and spatially explicit models to examine whether mesopredator release of the feral cat Felis catus occurs in response to targeted control of the introduced red fox Vulpes vulpes. We surveyed three Control‐Impact paired landscapes in a region with long‐term fox control (1080 poison baiting) and conducted a Before‐After Control‐Impact Paired‐Series experiment in another region. We used fox occurrence as a simple metric of fox populations and estimated feral cat density with spatial mark–resight models.3. Lethal fox control had varying effects on fox occurrence, consistent with variation in the duration and intensity of poison baiting. Correspondingly, responses in feral cat density ranged from negligible to a 3.7‐fold higher density in fox‐baited landscapes. At a fine spatial scale (200 m2), feral cat density was negatively associated with fox occurrence probability across both regions. These results were consistent with mesopredator release, although uncertainty was high in the region where fox control had only recently commenced.4. Feral cat detectability also varied across the (artificially manipulated) gradients of fox occurrence probability. In one region, nonlinear models indicated that feral cats had lower detection and increased movement rates when foxes were uncommon, giving way to density suppression at high fox occurrence probabilities.5. Synthesis and applications. Our study provides replicated, experimental evidence that dominant predator suppression can be associated with a higher mesopredator density. Mesopredator release can manifest as changes in both behaviour and density, distorting inference if these processes are not distinguished. Our results may help explain why fox control does not consistently improve native prey persistence, suggesting integrated pest management may be necessary to improve conservation outcomes.
The different facets of ‘experiential knowledge’ in Swedish women’s claims about systemic side effects of the copper intrauterine device
Authors: Gunnarsson Lena , Wemrell Maria 
Published: April 2023

Abstract‘Experiential knowledge’ has been identified as a key epistemic resource used by lay people to contest medical authorities and build new knowledge related to health. The Internet has created unprecedented opportunities for such experience‐based epistemic projects. This article contributes to understandings of the as yet under‐theorised concept of experiential knowledge by analysing accounts of a group of Swedish women who claim that their use of contraceptive copper IUDs has led to systemic side effects not recognised by health care providers. Based on digital group interviews and written essays, we distinguish between three components or stages of experiential knowledge at work in the women’s use of experience as an epistemic resource: somatic knowing, collective validation and self‐experimentation. Drawing on a critical realist framework, we defend a notion of experiential knowledge as crucially, while only partially, based on a bodily and practical access to aspects of reality organised by extra‐discursive principles. By providing theoretical complexity to the notion of experiential knowledge, we contribute resources for discriminating between and evaluating various experience‐based claims, something that is particularly needed in the current ‘post‐truth’ era where experience‐based knowledge claims pointing in divergent directions flourish.
Influence of dialysis‐related stigma on health‐related indicators in Japanese patients undergoing hemodialysis
Authors: Sugisawa Hidehiro , Shimizu Yumiko , Kumagai Tamaki , Shishido Kanji , Koda Yutaka , Shinoda Toshio 
Published: April 2023

AbstractIntroductionFocusing on impacts to health‐related indicators in older Japanese patients, this study analyzed both the direct influence of dialysis‐related stigma and influences of its intersectionality with other stigmatized characteristics.MethodsData were collected through a cross‐sectional survey of 7461 outpatients in dialysis facilities. Other stigmatized characteristics include lower income, lower education, disabled activities of daily living, and diabetic end‐stage renal disease (ESRD) as a cause for starting dialysis treatment.ResultsThe average rate of an “agree” response on dialysis‐related stigma items was 18.2%. Dialysis‐related stigma significantly influenced all three health‐related indicators, including suspected depression, informal networks, and compliance with dietary therapy. In addition, each interaction between dialysis‐related stigma and educational attainment, gender, and diabetic ESRD significantly influence one health‐related indicator.ConclusionThese results suggest that dialysis‐related stigma has both a significant direct and synergic influence with other stigmatized characteristics on health‐related indicators.
Review of the Australian butterfly genus Cyprotides Tite, 1963 (Lepidoptera: Lycaenidae), with descriptions of three new taxa
Authors: Braby Michael F. 
Published: April 2023

AbstractTaxonomic review of the monotypic Australian endemic lycaenid genus Cyprotides Tite, 1963, based on comparative evidence of adult and juvenile morphology and biology, indicates that it comprises three allopatric and ecologically distinct species: C. pallescens Tite, 1963 stat. rev., C. cyprotus (Olliff, 1886) and C. maculosus sp. nov. Cyprotides cyprotus is considered to comprise three subspecies: C. cyprotus cyprotus (Olliff, 1886) in the Sydney Sandstone region; C. cyprotus lucidus ssp. nov. in the semi‐arid zone of inland central New South Wales, north‐western Victoria, South Australia, and south‐western Western Australia; and C. cyprotus aridus ssp. nov. in the arid zone of southern Northern Territory and Western Australia. In contrast, C. maculosus sp. nov. appears to be a narrow‐range endemic, restricted to subalpine areas in south‐eastern Australia (~1100–1500 m asl). Information on the distribution, ecology and biology is reviewed and summarised for each of these five taxa, with additional data provided on the habitat and conservation status of C. maculosus sp. nov., which is considered to be Endangered under IUCN Red List Criteria. All three species appear to be characterised by predominantly univoltine life cycles but with variable pupal diapause that may last up to 2–3 years, larval polymorphism, facultative associations with ants, pupal stridulation and rapid larval development involving only four instars. It is hypothesised that speciation within this genus has occurred recently, driven by reinforcement following secondary contact, leading to pre‐mating isolation and character displacement, resulting in divergent phenotypes.
Editorial: first‐degree relatives of Mexican Americans with HCC are at increased risk of significant fibrosis
Authors: Guarnizo‐Ortiz Maria , Vilar‐Gomez Eduardo 
Published: April 2023

LINKED CONTENTThis article is linked to Sharpton et al papers. To view these articles, visit https://doi.org/10.1111/apt.17384 and https://doi.org/10.1111/apt.17475