bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Flurbiprofen ester in 4-dimensional hysterosalpingography : could it effectively relieve pain during infertility examination?
Authors: Tan Long , Wu Shi-ji , Ma Ai-lin , Li Shi-mei , Zhou Shang-lan , Zhang Shen , Chen Pei-xin , Luo Bao-ming , Di Na 
Published: May 2023

Abstract
Objective The purpose of this article is to investigate the analgesic effect of flurbiprofen ester injection continuous intravenous drip in transvaginal 4-dimensional hysterosalpingography (TVS 4D-HyCoSy).
Methods Two hundred thirty patients who underwent TVS 4D-HyCoSy for infertility from May 2018 to August 2021 at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, were selected. They were grouped according to tubal patency, flurbiprofen ester use, and uterine cannula diameter, i.e., bilateral tubal patency group and nonbilateral tubal patency group, atropine group and atropine + flurbiprofen ester group, and coarse tube group and fine tube group, to compare the analgesic effect during TVS 4D-HyCoSy, pain relief effect between groups, record the incidence of adverse effects, and analyze the factors related to the influence of pain.
Results 1. The atropine + flurbiprofen ester group had significantly fewer adverse effects in the former patients compared with the atropine group; 2. Flurbiprofen ester continuous intravenous infusion was effective for analgesia after ultrasound tubal contrast. Flurbiprofen ester continuous intravenous infusion was effective in relieving pain within 30 minutes after imaging regardless of the patency of the fallopian tubes; 3. The addition of flurbiprofen ester significantly relieved pain in the fine tube group in those with bilateral patency of the fallopian tubes and in the thick tube group and fine tube group in those with nonbilateral patency of the fallopian tubes; 4. Multifactorial analysis of pain relief during imaging suggested that the use of flurbiprofen for bilateral tubal patency had a significant positive effect on pain relief within 30 minutes after the examination, AUC 0.732; 95% CI: 0.665-0.798.
Conclusion Bilateral tubal patency and flurbiprofen will have a significant positive effect on pain relief. The analgesic effect of flurbiprofen ester injection with continuous drip started before TVS 4D-HyCoSy was good, and the pain relief effect was significant within 30 minutes after examination with few adverse effects, which is worthy of clinical promotion.
PSII photochemical efficiency and chlororespiration of Acropora millepora zooxanthellae in carbonated seawater
Authors: McNie Ashleigh , Breen Daniel , Vopel Kay 
Published: May 2023

Abstract
Global trends of increasing atmospheric CO2, warming and eutrophication enrich seawater with CO2—either by absorption from the atmosphere or by microbial respiration—increasing seawater [H+] and [HCO3–] but decreasing [CO32–]. We asked whether, in the absence of warming, these changes in inorganic carbon chemistry affect the PSII photochemical efficiency of zooxanthellae in the reef building coral Acropora millepora. We assessed this efficiency experimentally using pulse-amplitude-modulation fluorometry at a temperature of 25°C, a daily maximum photosynthetically active radiation of ~ 65 µmol quanta m–2 s–1, and a seawater pCO2 that we gradually increased post-acclimation over nine days from ~ 496 to ~ 1290 µatm by injection of CO2 enriched air. Statistical analyses of fluorescence variables derived from saturation pulses delivered every 30 minutes and during induction–recovery experiments did not reveal evidence for an effect of CO2 enrichment on the PSII photochemical efficiency. Two of the three experiments, however, indicate the possibility of a positive effect of CO2 counteracting the gradual decrease in the photochemical efficiency that was observed under conditions of ambient seawater pCO2. Furthermore, we present evidence for chlororespiration—a nocturnal decrease in the PSII photochemical efficiency followed by a sharp increase at the onset of low irradiance. We conclude that seawater CO2 enrichment may not decrease the capacity for photosynthesis in A. millepora zooxanthellae to supply carbon of use in meeting the coral’s energy expenditures.
Performance testing of selected hybrid Markovian models in urban growth simulation of the Kolkata Metropolitan Area, India
Authors: Santra Abhisek , Mitra Shreyashi S. , Routh Shidharth , Kumar Akhilesh , Mitra Debashis 
Published: May 2023

Abstract
In this study an attempt was made to compare the performance of three widely accepted Markovian models of urban growth based on Cellular Automata (CA_MC), Multi-Layer Perceptron (MLP_MC), and Logistic Regression (LR_MC) in the Kolkata Metropolitan Area. The long-term Landsat images (from 1975 to 2020) were used to study the urban growth. A set of performance metrics, i.e., Kappa, Probability of Detection, False Alarm Ratio, Critical Success Index, and Accuracy Score, were employed to assess the accuracy of the model outputs. Different factors and constraints, were considered to observe their impacts on urban growth. The results indicate that while AHP-based CA_MC performs better overall, relying on any one performance metric alone may provide a misleading conclusion. It was observed that the CA_MC with the AHP performed the best and used for future simulation of the urban land-use/cover maps was generated from 2025 to 2070 at regular intervals. Much of that happens at the expense of the agricultural lands and vegetation cover, which are predicted to decrease by 18% and 5.3%, respectively. The distance-directional growth analysis showed that the areas closer to the central locations are expected to reach saturation, and the fringe areas are expected to register higher urban growth.
Canine ex vivo tarsal arthrodesis: fixation by using a new bone tissue glue
Authors: Lundin Tobias , Pujari-Palmer Michael , Svensson Gustaf , Höglund Odd Viking 
Published: May 2023

AbstractBackgroundArthrodesis, performed as a salvage surgical procedure to treat intractable joint conditions in dogs and cats, is associated with a high incidence of complications intra and postoperative. Proving the need for improved and new techniques in arthrodesis surgery. Adding a new resorbable bone glue to the arthrodesis could potentially ad fixation strength and lower complications. The objectives of this experimental ex vivo biomechanical study were therefore to develop a biomechanical test model of partial tarsal arthrodesis and to determine whether the new resorbable bone glue (phosphoserine modified cement) produced measurable fixation strength in canine calcaneoquartal arthrodesis, without orthopedic implants. Four biomechanical test models with a total of 35 canine tarsal joints were used. Soft tissues were dissected to 4 different test models with variable contributions from soft tissues. The calcaneoquartal joint was prepared as in vivo arthrodesis and the glue was applied to joint surfaces as a liquid/putty (0.4 cc). After curing for 24 hours, a shear force was applied to the joint (1 mm per minute) and the failure strength was recorded.ResultsCalcaneoquartal joints, where all soft tissues had been completely resected and fixated with glue (1-1.5 cm2joint surface), withstood 2-5 mm of displacement and an average of 100 ± 58 N/cm2of shear force (Model 1). Similar adhesive fixation strengths were obtained in Model 2 and 3 with increasing contributions from soft tissues (80 ±44 and 63 ±23 N/cm2, p = 0.39, ANOVA).ConclusionThe developed biomechanical model was sensitive enough to measure differences in fixation strengths between different glue formulations. The average fixation strength (60-100 N/cm2) should be strong enough to support short-term load bearing in medium sized canines (20 kg). The developed cadaver biomechanical test model is of potential use for other arthrodesis studies. The new resorbable glue can potentially contribute to stability at arthrodesis surgery, acting as a complement to today’s standard fixation, metal implants.
Linking functional and structural brain organisation with behaviour in autism: A multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study
Authors: Oblong Lennart M , Llera Alberto , Mei Ting , Haak Koen , Isakoglou Christina , Floris Dorothea L , Durston Sarah , Moessnang Carolin , Banaschewski Tobias , Baron-Cohen Simon , Loth Eva , Dell’Acqua Flavio , Charman Tony , Murphy Declan G M , Ecker Christine , Buitelaar Jan K , Beckmann Christian F , group the EU-AIMS LEAP group the EU-AIMS LEAP , Forde Natalie J 
Published: May 2023

Abstract
Neuroimaging analyses of brain structure and function in autism have typically been conducted in isolation, missing the sensitivity gains of linking data across modalities. Here we focus on the integration of structural and functional organisational properties of brain regions. We aim to identify novel brain-organisation phenotypes of autism. We utilised multimodal MRI (T1-, diffusion-weighted and resting state functional), behavioural and clinical data from the EU AIMS Longitudinal European Autism Project (LEAP) from autistic (n = 206) and non-autistic (n = 196) participants. Of these, 97 had data from 2 timepoints resulting in a total scan number of 466. Grey matter density maps, probabilistic tractography connectivity matrices and connectopic maps were extracted from respective MRI modalities and were then integrated with Linked Independent Component Analysis. Linear mixed-effects models were used to evaluate the relationship between components and group while accounting for covariates and non-independence of participants with longitudinal data. Additional models were run to investigate associations with dimensional measures of behaviour. We identified one component that differed significantly between groups (coefficient = 0.33, padj = 0.02). This was driven (99%) by variance of the right fusiform gyrus connectopic map 2. While there were multiple nominal associations with behavioural measures, none were significant following multiple comparison correction. Our analysis considered the relative contributions of both structural and functional brain phenotypes simultaneously, finding that functional phenotypes drive associations with autism. These findings expanded on previous unimodal studies by revealing the topographic organisation of functional connectivity patterns specific to autism and warrant further investigation.
The genetic variability of grapevine Pinot gris virus (GPGV) in Australia
Authors: Kaur Kamalpreet , Rinaldo Amy , Lovelock David , Rodoni Brendan , Constable Fiona 
Published: May 2023

Abstract
Grapevine Pinot gris virus (GPGV; genus Trichovirus in the family Betaflexiviridae) was found in Australia in 2016, but the impact on the production of nursery material and fruit in Australia is unknown. This study investigated the prevalence and genetic diversity of GPGV in Australia. GPGV was detected by reverse transcription-polymerase chain reaction (RT-PCR) in a range of rootstock, table and wine grape varieties from New South Wales, South Australia, and Victoria and 473/2171 (21.8%) samples were infected. Genomes of 32 Australian GPGV isolates were sequenced and many of the isolates shared high nucleotide homology. Phylogenetic and haplotype analyses demonstrated that there were four distinct clades amongst the 32 Australian GPGV isolates and that there were likely to have been at least five separate introductions of the virus into Australia. Recombination and haplotype analysis indicate the emergence of new GPGV strains after introduction into Australia. When compared with 168 overseas GPGV isolates, the analyses suggest that the most likely origin of Australian GPGV isolates is from Europe. There was no correlation between specific GPGV genotypes and symptoms such as leaf mottling, leaf deformation, and shoot stunting, which were observed in some vineyards, and the virus was frequently found in symptomless grapevines.
Repositories
Accession numbers: OQ198990 - OQ199021
Impression formation and autism spectrum disorder: the role of interpersonal synchrony
Authors: Plank Irene Sophia , Traiger Leora Sephira , Nelson Afton M. , Koehler Jana Christina , Lang Stefanie Franziska , Tepest Ralf , Vogeley Kai , Georgescu Alexandra Livia , Falter-Wagner Christine M. 
Published: May 2023

Abstract
When people meet, they almost instantaneously form an impression of each other. First impressions of character traits and rapport are less favourable when people with autism spectrum disorder (ASD) are judged compared to non-autistic people. Little is known about the behavioural differences that drive these altered impressions. In the present study, we investigated the influence of interpersonal synchrony on impression formation of autistic and non-autistic people. Specifically, we used lagged cross-correlations to assess how much each interactant’s motion energy, a measure which can be determined from video recordings, influenced the other interactant’s motion energy. In short, silent clips of dyadic conversations, we asked non-autistic participants to rate their impression of one of the two interactants, which was solely based on the outlines of both interactants. We expected that the amount of leading of the target interactant, their diagnostic status as well as the interaction of these factors would influence impression formation. We found that while the amount of leading had a positive effect on the impressions of non-autistic interactants, this was not true for interactants with ASD. This suggests that interpersonal synchrony of motion energy is one driver of less favourable impressions of autistic compared to non-autistic people.
High endophytic diversity associated with roots of Cattleya milleri, an endemic orchid from rupestrian grasslands of the “Quadrilátero Ferrífero”, a Brazilian savanna hotspot area in Minas Gerais
Authors: Pereira Marlon Corrêa , Cunha Paloma Cavalcante , Teixeira Anita Fernanda dos Santos , Silva Leandro Israel da , Valadares Rafael Borges da Silva , Dória Joyce , Costa Paulo Henrique de Oliveira , Moreira Fatima Maria Souza 
Published: May 2023

Abstract
Cattleya milleri is a microendemic orchid of iron-rich rupestrian grasslands in the Brazilian savanna hotspot. It is under critical threat due to illegal collections and habitat destruction. As endophytic and mycorrhizal fungi have potential application during C. milleri propagation and conservation, we investigated its root fungal community. C. milleri roots were sampled in five natural sites and at a greenhouse. Fungal root endophytes were isolated for cultural characterization and molecular ITS (Internal Transcribed Spacer) identification. Total DNA was extracted from root endorhiza and rhizosphere to ITS amplification and sequencing. Sixteen fungal isolates were clustered in 6 Operational Taxonomic Units (OTUs), while endorhizal and rhizospheric sequences were clustered in 327 OTUs. Endorhiza richness (OTUs number) ranged from 25 to 89 OTUs, and rhizosphere presented 56 OTUs. Cluster analysis showed high divergence between natural and greenhouse environments, but a small distance among natural samples. Four phyla, 48 orders, 81 families, and 94 genera were annotated. The putative role of 134 OTUs was annotated, and 24 genera were endophytes, 2 mycorrhizas, 33 pathotrophs, 40 saprotrophs and 17 symbiotrophs. Three orders containing endophytes (Capnodiales, Hypocreales, and Pleosporales) and one containing mycorrhizae (Sebacinales) occurred in all sites. The mycorrhizae Tulasnella occurred in all natural samples. The presence of only two mycorrhizal taxa suggested the mycorrhizae may limit C. milleri distribution. However, many fungi can be recruited from the environment as non-mycorrhizal endophytes. Considering their abundance and role in orchid development, Pleosporales, Tulasnella, and Sebacinalles may be considered for C. milleri propagation and conservation.
Clinical pregnancy rate for frozen embryo transfer with HRT: a randomized controlled pilot study comparing 1 week versus 2 weeks of oestradiol priming
Authors: Racca Annalisa , Santos-Ribeiro Samuel , Drakopoulos Panagiotis , De Coppel Yoran , Landuyt Lisbet Van , Tournaye Herman , Blockeel Christophe 
Published: May 2023

AbstractResearch Question:Does a frozen-embryo transfer in an artificially-prepared endometrium (FET-HRT) cycle yield similar clinical pregnancy rate with 7 days of oestrogen priming compared to 14 days?Design:this is a single-centre, randomized, controlled, open-label pilot study. All FET-HRT cycles were performed in a tertiary centre between October 2018 and January 2021. Overall, 160 patients were randomized, with a 1:1 allocation, into two groups of 80 patients each: group A (7 days of E2 prior to P4 supplementation) and group B (14 days of E2 prior to P4 supplementation). Both groups received single blastocyst stage embryos on the 6th day of vaginal P4 administration. The primary outcome was the feasibility of such strategy assessed as clinical pregnancy rate, secondary outcomes were biochemical pregnancy rate, miscarriage rate, live birth rate and serum hormone levels on the day of FET.Chemical pregnancy was assessed by an hCG blood test 12 days after FET and clinical pregnancy was confirmed by transvaginal ultrasound at 7 weeks.Results:The analysis included 160 patients who were randomly assigned to either group A or group B on the seventh day of their FET-HRT cycle if the measured endometrial thickness was above 6.5 mm. Following screening failures and of drop-outs, 144 patients were finally included both in group A (75 patients) or group B (69 patients). Demographic characteristics for both groups were comparable. The biochemical pregnancy rate was 42.5% and 48.8% for group A and group B, respectively (p 0.526). Regarding the clinical pregnancy rate at 7 weeks, no statistical difference was observed (36.3% vs 46.3% for group A and group B, respectively, p=0.261). The secondary outcomes of the study (biochemical pregnancy, miscarriage, and live birth rate) were comparable between the two groups for IIT analysis, as well as the P4 values on the day of FET.Conclusions:In a frozen embryo transfer cycle, performed with artificial preparation of the endometrium, 7 versus 14 days of oestrogen priming are comparable, in terms of clinical pregnancy rate; the advantages of a seven-day protocol include the shorter time to pregnancy, reduced exposure to oestrogens, and more flexibility of scheduling and programming, and less probability to recruit a follicle and have a spontaneous LH surge.It is important to keep in mind that this study was designed as a pilot trial with a limited study population as such it was underpowered to determine the superiority of an intervention over another; larger-scale RCTs are warranted to confirm our preliminary results.Clinical trial number:NCT03930706
A Fast Multilevel Dimension Iteration Algorithm for High Dimensional Numerical Integration
Authors: FENG XIAOBING , ZHONG HUICONG 
Published: May 2023

Abstract
In this paper we propose and study a fast multilevel dimension iteration (MDI) algorithm for computing arbitrary d-dimensional integrals based on the tensor product approximations. It reduces the computational complexity (in terms of the CPU time) of a tensor product method from the exponential order O(Nd) to the polynomial order O(d3N2) or better, where N stands for the number of quadrature points in each coordinate direction. As a result, the proposed MDI algorithm effectively circumvents the curse of the dimensionality of tensor product methods for high dimensional numerical integration. The main idea of the proposed MDI algorithm is to compute the function evaluations at all integration points in cluster and iteratively along each coordinate direction, so lots of computations for function evaluations can be reused in each iteration. This idea is also applicable to any quadrature rule whose integration points have a lattice-like structure.
AMS subject classifications. 65D30, 65D40, 65C05, 65N99
Efficacy and toxicity of stereotactic body radiotherapy for un-resectable stage III non-small cell lung cancer patients unfit for concurrent chemoradiation therapy: A retrospective study
Authors: Jia Zhen , Fang Fang , Cao Yangsen , Zhu Xiaofei , Yang Xiaoyu , Guo Xueling , Zhang Huojun 
Published: May 2023

Abstract
Background In this study, we evaluated the efficacy and toxicity of stereotactic body radiotherapy (SBRT) as replacement strategy of conventionally fractionated radiation therapy in stage III non-small cell lung cancer (NSCLC) patients unfit for concurrent chemoradiation therapy (CRT).
Methods We analyzed the clinical outcomes in patients with unresectable stage III NSCLC who received SBRT from January 1, 2013 to December 31, 2018. Both induction and consolidation chemotherapy were allowed. The survival rates and toxicities were calculated using the Kaplan-Meier method, and potential risk factors were investigated by multivariate Cox regression.
Results A total of 213 consecutive patients who had received SBRT were enrolled. The median overall survival (OS) and progression-free survival (PFS) were 36.5 months and 16.1 months respectively. The estimated 1-, 2-, 3-, and 5-year OS rates were 90.6%, 73.7%, 52.0% and 24.9%, respectively and the corresponding PFS rates were 69.5%, 25.4%, 15.0%, and 10.0%, respectively. Treatment failures were largely (n=151, 70.9%) distant metastases, with low rates of local (n=74, 34.74%) and regional (n=76, 35.68%) recurrences. In 13.1% patients (n=28), ≥ grade (G) 3 toxicities were identified, including radiation pneumonia (n=20, 9.4%) and bronchopulmonary hemorrhage (n=8, 3.8%). None of the patients suffered from ≥G 3 late toxic effects. Compared with patients with peripheral tumors, patients with central tumors had lower median OS (P﹤0.001) and the biological effective dose (BED) was not a predictor for OS.
Conclusions SBRT combined with chemotherapy for stage III NSCLC produced favorable treatment outcomes with acceptable toxicity. For patients with central tumors, an appropriate BED reduction can be considered. Further studies are warranted.
Trial registration Retrospectively registered.
An Efficient Method to Identify Regions of Initial Condition Uncertainty for Short-Range Rainfall Forecast during Indian Summer Monsoon Season
Authors: GEORGE BABITHA , Kutty Govindan 
Published: May 2023

Abstract
Forecast errors can be reduced if observations are assimilated in regions with the largest percentage of analysis error growth. Adjoint or ensemble sensitivity analysis provides a way to determine the relationship between a scalar forecast metric and analysis/forecast state variable whereby regions with the largest sensitivity can be identified. In this study, the regions where additional observations will impact the forecasts over the Indian subcontinent during the summer monsoon season have been identified using the ensemble approach. Five years of ensemble data drawn from the National Centers for Environmental Prediction (NCEP) The Observing System Research and Predictability Experiment (THORPEX) Interactive Grand Global Ensemble (TIGGE) archive has been used to perform ensemble sensitivity analysis (ESA). Regions with the largest percentage of sensitive forecast cycles may be considered as potential locations for launching new observations. Results show that the climatological sensitivity fields of the target forecast region are most often located in its upstream regions in the analysis. It is found that the region of frequent sensitivity may significantly vary with the forecast variable used in the calculation. The 24-h and 48-h precipitation forecasts averaged over the Western Ghats are most often sensitive to far south of the target forecast region. The region of sensitivity for the forecast domain located over the Gangetic Basin and North-Eastern region of the Indian subcontinent is identified to be a zonally elongated region over central India and head Bay, respectively.