bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photoperiod response corresponds to different circadian entrainment properties in northern and southern Nasonia vitripennis lines
Authors: Floessner Theresa S.E. , Benetta Elena Dalla , Beersma Domien G.M. , Hut Roelof A. 
Published: May 2023

Abstract
The circadian clock times physiological and behavioural processes and resets on a daily basis to synchronize with the environment. The involvement of the circadian clock in photoperiodic time measurement synchronising annual rhythms is still under debate and different models have been proposed explaining their integration. Insects overcome unfavourable conditions in diapause, a form of dormancy. A latitudinal cline in diapause induction in the parasitoid wasp Nasonia vitripennis as well as a difference in circadian light sensitivity between north and south provide us with additional evidence that the circadian system of Nasonia is involved in photoperiodic time measurement and that circadian adaptation is a potential mechanism driving latitudinal adaptation in photoperiodism. We tested diapause induction in a range of T-cycles and photoperiods and found diapause induction in short photoperiods in all T-cycles in the northern line but in the southern line diapause only occurred in T-cycles close to 24 h. Due to a lower light sensitivity in the southern line, a wider distribution of phase angles of entrainment can be expected at a specific T-cycle duration, while the range of entrainment will decrease. Taking these oscillator properties into account, our data can be explained by an external coincidence model involving a single oscillator with a light-sensitive phase that drives annual timing of diapause in Nasonia vitripennis.
Effect of dihydromyricetin combined with cisplatin on treatment of lung cancer cell A549
Authors: Miao Hao , Pang Chong , Zhu Wenjing , Zhao HanZheng , Zhang Wenhui , Yang Fang , Song Zhichao , Sun Dayong , Zuo Yanzhen 
Published: May 2023

Abstract
Objective Chemotherapy resistance and side effects are important reasons for the failure of lung cancer treatment. Therefore, finding new sensitizers for chemotherapeutic drugs is an urgent problem to be solved.Method In this study, A549 cells were given different pharmacological interventions, including control, cisplatin, DMY and the combination of cisplatin and DMY. The level of cell proliferation and apoptosis were detected by MTT assay and Flow cytometry AV/PI double staining. Transwell assay was adopted to detect the ability of migration and invasion of A549 cells. Western blot analyzed the expression of protein about proliferation, apoptosis, migration, and invasion.Results The present study denoted that DMY strengthened the effect of cisplatin on the inhibition of proliferation in lung cancer A549 cells. Meanwhile, DMY promoted cisplatin induced apoptosis of A549 cells. Further, DMY combined with cisplatin can synergistically inhibit the migration and invasion of A549 cells. Western blotting results showed that the expression of E-cadherin was significantly increased in the combination group compared to cisplatin group, while, the expression of N-cadherin, matrix metalloproteinase MMP 2, MMP 9 and Smads proteins (p-SMAD 3, t-SMAD 3, t-SMAD 4), were significantly decreased in the combination group.Conclusion Low dosage of DMY can significantly enhance the effect of cisplatin treatment in lung cancer cells, and its mechanism may be related to the induction of apoptosis, inhibition of proliferation, migration and invasion, which is expected to be a low-toxic and efficient chemosensitizer for lung cancer treatment.
Federated Learning with GANs-based Synthetic Minority Over-sampling Technique for Improving Weather Prediction from Imbalanced Data
Authors: Jafarigol Elaheh , Trafalis Theodore B. 
Published: May 2023

Abstract
Detecting rare events is a challenging task among machine learning practitioners, motivating them to navigate and further improve data processing and algorithmic approaches to find accurate and computationally efficient methods for imbalanced learning. Imbalanced data is common in weather prediction, where the massive size of data poses storage and computational challenges. To learn from imbalanced data, the algorithms must strive to learn each class precisely to be able to classify both the minority and the majority class. While creating complex models is somewhat necessary for such problems, the machine learning algorithm must have adequate generalization capabilities. In recent years, federated learning has been used as an environmentally-friendly approach, which can produce accurate results in a distributed setting. Although privacy is not a concern of this study, inherent characteristics of federated learning are beneficial in weather prediction. Deep learning combined with data augmentation is explored in the framework of federated learning. We compare multiple data augmentation methods in a centralized and federated learning framework. Federated learning has great potential for weather prediction tasks. By leveraging data from multiple sources, we were able to improve the accuracy and generalization of the classifier. Addressing the issue of imbalanced data is an essential step. Incorporating the two remarkable approaches of Generative Adversarial Networks and Synthetic Minority Over-sampling Technique is a suitable solution for tabular weather data, and our experimental results confirm the effectiveness of this approach.
Flexible In-Cavity MRI Receiving Coil for Ultrahigh Resolution Imaging of the Pituitary Gland
Authors: Liu Siyuan , Patel Kunal S , Peeters Sophie , Lin Jiahao , DiRisio Aislyn C , Vinters Harry , Candler Robert , Sung Kyunghyun , Bergsneider Marvin 
Published: May 2023

Abstract
Purpose Preclinical design and construction of a flexible intra-sphenoid coil aiming for submillimeter resolution of the human pituitary gland.Methods Sphenoid sinus measurements determined coil design constraints for use in > 95% of adult patients. Temperature safety parameters were tested. The prototype 2-cm diameter coil was positioned in the sphenoid sinus of cadaveric human heads utilizing the transnasal endoscopic technique that is used clinically. Signal-to-noise ratio (SNR) was estimated comparing the prototype transnasal coil versus a standard clinical head coil. One cadaver pituitary gland was explanted and histologically examined for correlation to the imaging findings.Results With the coil positioned directly atop the sella turcica at 00 angle of the B0 static field, the craniocaudal distance (24 ± 4 mm) was the limiting constraint. Phantom experiments showed a negligible change in temperature at two sites over 15 minutes. The flexible coil was placed transnasally in cadaveric specimens using an endoscopic approach. The image quality was subjectively superior at higher spatial resolutions relative to the commercial 20-channel head coil. An average 17-fold increase in SNR was achieved within the pituitary gland. Subtle findings visualized only with the transnasal coil had potential pathological correlation with immunohistochemical analysis.Conclusions A transnasal radiofrequency coil feasibly provides a 17-fold boost in SNR at 3T, providing, in principle, equivalent imaging to a 51T scanner using a standard head coil. The ability to safely improve the quality of pituitary imaging may be helpful in the identification and subsequent surgical resection of small functional pituitary lesions.
Cyber Security Standards in Popular Russian Websites through HTTP Observatory measurements
Authors: Xue Xingsi , Aghbolagh Mohsen Abdollahzadeh , Noeiaghdam Samad 
Published: May 2023

Abstract
Online user security is strongly reliant on a number of factors. One of the most important steps in enhancing data and communication security on well-known websites and a variety of internet services is adhering to security standards and using reliable and cutting-edge technology. These standards and technologies were developed and tested recently. Our investigation at the CERTFA Lab on 50 well-known websites shows that their security is comparable to that of the rest of the world, and very few websites are completely utilizing new security standards and technology. In fact, Russia has strong and comprehensive cyber capabilities. Websites run by the Russian government are subject to unprecedented cyberattacks, and technical measures have been taken to block international online traffic. Although domestic websites have operated successfully within the nation, some security measures need to be taken more seriously. According to our investigation, 47 of the websites we looked into have been configured with CSP2, with Yandex.ru, Ozon.ru, and wileberries.ru's implementations having more specifics and being more secure than those of the other websites, which used the upgrade-insecure-requests option as the default setting for CSP. Additionally, the results of the analysis of contemporary standards used in this study (DNSSEC, CAA, DMARC, SPF, and Expect-CT), which are mandated for the majority of Internet businesses, show that well-known Russian websites have correctly implemented these standard configurations.
Increased starting doses of exogenous gonadotropins do not improve IVF-ET outcomes in expected poor ovarian responders
Authors: Xiao-Yan Xu , Wu Zhi-Juan , Qi Ying-Hua , Pang Cong-Hui , Sun Zhen-Gao , Song Jing-Yan 
Published: May 2023

Abstract
Background To evaluate whether increasing the starting dose of exogenous gonadotropins (Gn) improves in vitro fertilization and embryo transfer (IVF-ET) outcomes in patients with the expected poor ovarian response (POR), as defined by antral follicles count (AFC) ≤ 9. The outcomes of IVF-ET in patients with expected POR between January 2016 and December 2021 were compared retrospectively. A total of 2448 IVF cycles were studied, including 709 with a starting Gn dose of 150 IU (Group A), 1006 with 225 or 300 IU (Group B), and 733 with 375 or 450 IU (Group C). The cumulative live birth rate was the primary outcome, with secondary outcomes including the number of oocytes retrieved, the number of normal fertilization, the number of transferable embryos, positive pregnancy, clinical pregnancy, pregnancy loss, ectopic pregnancy of fresh embryo transfer, and cycle cancellation rate. Multivariate logistic regression analysis was used to control the confounding factors.Results The cumulative live birth rates (28.2% in group A vs. 23.6% in group B vs. 17.9% in group C, P < 0.001) were statistically significant. The relationship between cumulative live birth rate and grouping was investigated using multivariate logistic regression. The odds ratio (OR) of group B versus group A was 0.887, 95% confidence interval (CI) 0.655–1.174, P = 0.378, and the OR of group C versus group A was 0.77, 95% CI 0.545–1.089, P = 0.139. The total number of retrieved oocytes was 4.49 ± 3 in group A, 4.53 ± 2.8 in group B, and 3.91 ± 2.6 in group C. P < 0.001 indicated that the differences were statistically significant. Multivariate logistic regression was used to investigate the relationship between the number of retrieved oocytes and grouping. The OR of group B versus group A was 0.993, 95% CI 0.713–1.383, P = 0.966, and the OR of group C with group A was 0.881, 95% CI 0.614–1.264, P = 0.492.Conclusions Increasing the starting dose of Gn did not increase the number of oocytes retrieved or the cumulative live birth rate in POR patients.
The Italian Version of the Majeed Pelvic Score: Translation, Cross-Cultural Adaptation and Validation
Authors: Cattaneo Stefano , Vittone Giulio , Galante Claudio , Domenicucci Marco , Milano Giuseppe , Casiraghi Alessandro 
Published: May 2023

Abstract
Purpose The assessment of functional outcomes after pelvic ring fracture remains a controversial topic. The Majeed pelvic score (MPS) is the most commonly used pelvic-specific questionnaire in the literature. The aim of this study is translation, cross-cultural adaptation and validation of the Italian version of MPS.Methods The study was articulated in two phases. Phase 1 consisted in translation and cross-cultural adaptation of MPS, from English into Italian. The psychometric properties were tested on 52 Italian patients (Phase 2). Construct validity was assessed by correlation with Short-Form 12 (SF-12). 33 patients repeated the questionnaire after 14 days to assess its reproducibility. All data were subsequently analyzed (descriptive statistics, multitrait analysis, reliability and construct validity assessment).Results The questionnaire was clear and easily understood (no missing data). A ceiling effect was detected for all items of the scale. Multitrait analysis showed good results for each outcome measure, except for the item “walking distance” that showed poor item discriminant validity. A significant correlation between the MPS and the physical component summary (PCS) of the SF-12 was found, while there was a weak correlation with the mental component summary (MCS). The questionnaire showed high internal consistency (Cronbach’s alpha: 0.91–0.99) and very good test-retest reliability (intraclass correlation coefficients: 0.92–0.96).Conclusions The Italian version of the MPS has demonstrated to be reliable and valid in the evaluation of patients with pelvic ring fractures. There is still however a need for an instrument capable of evaluating the mental component in these types of injuries.
Prevalence and risk factors of Neospora caninum in aborted fetus of sheep, goat, cattle, and buffalo
Authors: Shahiduzzaman Md. , Biswas Pijush , Kabir Ajran , Wakid Majed H. , Ahmed Nurnabi , Hossain Md. Zawad , Amin A R M Beni 
Published: May 2023

Abstract

BackgroundNeospora caninum, a protozoa that is a leading cause of neurological illness in dogs (definitive host), abortion in cattle (intermediate host) and sporadic disease in other livestock species (sheep, goats, horses and other carnivores). The study was aimed to reveal the molecular epidemiology ofN. caninumin aborted fetuses of cattle, goats, sheep and buffaloes in Bangladesh.MethodsIn total, 157 aborted fetuses (50 Cattle, 46 Buffaloes, 34 Goats and 27 Sheep) were randomly collected from various regions of Bangladesh. DNA was extracted from brain tissue to perform nested PCR and sequencing of ITS1 rDNA gene ofN. caninum.ResultsA total of 20 aborted fetuses out of 157 were positive forN. caninuminfection. Higher prevalence was observed in cattle (16.0%) followed by sheep (14.8%), goats (11.8%) and buffaloes (8.7%). Highest prevalence was found in animals during second trimester (21.51%) with aged 2 to 4 years (15.8%). Sequences from representative positive samples showed similarity between 99–100% forN. caninumITS1 rDNA gene with other best hit scoring GenBank sequences. Multivariate logistic regression demonstrated that abortion in pregnancy, abortion history of the animals, contact with dog feces or presence of dog in animals farm or premises and management practices were significantly (p ≤ 0.001) correlated withN. caninuminfection.ConclusionThe study findings indicated thatN. caninuminfection is one of the major causes of abortion and economic loss in livestock farming. Broader molecular epidemiology is imperative for strategic planning to control and prevent neosporosis in livestock.
LINC00606 regulates glioblastoma progression by sponging miR-486-3p and interacting with ATP11B
Authors: Dong Naijun , Qi Wenxin , Wu Lingling , Li Jie , Zhang Xueqi , Wu Hao , Zhang Wen , Jiang Jiawen , Zhang Shibo , Fu Wenjun , Liu Qian , Wang Jiao , Zhao Robert Chunhua 
Published: May 2023

Abstract
Background
LncRNAs regulate tumorigenesis and development in a variety of cancers; nevertheless, the biological functions and molecular mechanisms of LINC00606 in glioblastoma (GBM) remain largely unknown.
Methods
The expression of LINC00606 and ATP11B in glioma and normal brain tissues was evaluated by qPCR, and the biological functions of the LINC00606/miR-486-3p/TCF12/ATP11B axis in GBM were verified through a series of in vitro and in vivoexperiments. The molecular mechanism of LINC00606 was revealed by immunoblotting, FISH, RNA pulldown, CHIP-qPCR, and a dual-luciferase reporter assay.
Results
LINC00606 is highly expressed in GBM patient samples and is related to the poor prognosis. Here, LINC00606 promoted the proliferation, clonal expansion, and migration of glioma cells and reduced the levels of apoptosis. LINC00606 targets TCF12 by sponging miR-486-3p, which has been proven to affect the transcriptional initiation of LINC00606, PTEN, and KLLN. In addition, by working in concert with ATP11B, LINC00606 regulates the PI3K/AKT signaling pathway to mediate the proliferation, migration, and apoptosis of glioma cells.
Conclusion
The LINC00606/miR-486-3p/TCF12/ATP11B axis is involved in the regulation of glioma progression and plays a specific regulatory role at both the transcriptional and post-transcriptional levels via the sponging of miR-486-3p by LINC00606 to target TCF12 and the interaction of LINC00606 with ATP11B, interference with which may prove to be a new strategy for the treatment of glioblastoma.
Cost analysis of Telemedicine use in Pediatric Nephrology -The LMIC perspective
Authors: Dev Vishnu , Mittal Aliza , Joshi Vibha , Meena Jitendra Kumar , Goel Akhil Dhanesh , Didel Siyaram , Pareek Puneet , Misra Sanjeev , Singh Kuldeep 
Published: May 2023

Abstract
Background
The overall cost of managing chronic diseases is a significant barrier to accessing complete and timely healthcare, especially in rural and geographically isolated areas. This cost disparity becomes more pronounced in the case of children and more so in under-resourced regions of the world. In the era of COVID-19, as the need for physical distancing increased, there was a transition in approach to healthcare provision to Telemedicine consultations. The cost saving using teleconsultations is evaluated in this study in a pediatric nephrology clinic.
Methodology
This prospective cohort study was conducted at a tertiary care center in western Rajasthan from March 2021 to October 2022. All consecutive pediatric (29 days -18 years) patients attending telemedicine services for renal-related illness were enrolled. Basic demographic details were collected. The cost analysis was done after six months, in terms of perceived cost savings by a telemedicine consultation compared to an in-person visit during six months starting from enrolment.
Results
One hundred twelve patients were enrolled. Two hundred sixty-six teleconsultations attended. The 109 patients who could be followed up saved INR 4,57,900 during six months of follow-up. ( 3 lost to follow-up). The average cost saving was INR -1577/patient/visit. The patients saved 4.99 % of the family income [Median of 2.16 %( IQR: 0.66-5.5 %)]. The Highest expenditure per visit was incurred for food and transport. The median distance from the residence to the clinic was 122.5 km (IQR: 30-250). Over the six-month study period, our patients have saved a travel distance of 83274 km. (743 km per patient).
Conclusion
The use of telemedicine as a follow-up method helps save significant costs and distances travelled by patients.
Between Reality and Delusion: Challenges of Applying Large Language Models to Companion Robots for Open-Domain Dialogues with Older Adults
Authors: Irfan Bahar , Kuoppamäki Sanna-Mari , Skantze Gabriel 
Published: May 2023

Abstract

This work aims to provide initial guidelines towards developing companion robots with large language models (LLMs) to be part of everyday lives of older adults. Using iterative participatory design (co-design) approaches, we analyze the challenges of applying LLMs for multi-modal open-domain dialogue, deriving from older adults' (one-to-one) interactions with a personalized companion robot, built on Furhat robot with GPT-3.5. An initial study with 6 Swedish-speaking older adults (65 and older) showed that the robot frequently interrupted the users, responded slowly and repetitively, engaged in superficial conversations, and caused a barrier in the interaction due to foreign language (English). Upon incremental technical developments to address these issues, participatory design workshops were conducted with 28 Swedish-speaking older adults. While the interactions (in Swedish) were smoother, less disrupted, and more varied in topics and responses, further challenges were observed due to hallucinations and obsolete information, and disengagement cues, causing frustration, confusion, and worry.
Investigations on the effects of forming conditions on the deformation behaviors of copper-steel bimetallic rods during cold drawing processes
Authors: Hwang Yeong-Maw , Tsui Hiu Shan Rachel , Lu Cheng-Yu 
Published: May 2023

Abstract
Metal composites are widely used in different industries owing to their significant improvement in material properties such as mechanical strength, electrical conductivity, and corrosion resistivity compared to traditional metals. Such composites can be manufactured and processed in different ways to achieve the desired geometry and quality, among different metal forming techniques, drawing is the one that can be used to produce metal composites from raw materials or as a secondary processing method for metal composites. The drawing processes of the two cases are basically the same except for the initial bonding conditions of the billets. In this paper, bimetallic rods with AISI-1006 Low Carbon Steel core and C10100 Oxygen-Free Electronic Copper sleeve are modeled using finite element software DEFORM. The simulation models are verified by drawing experiments. The effects of initial bonding conditions, initial core ratio, reduction ratio, semi-die angle, drawing speed, and friction on the plastic deformation behaviors of the bimetallic rods are investigated. The results indicate that the initial bonding conditions have a great impact on the deformation behaviors of the billets in terms of strain distribution, material flow, residual stress, and final core ratio. With the aid of these analyses, the drawing process and the quality of the products can then be controlled more easily.
Deep Learning Based Analysis of Student Aptitude for Programming at College Freshman Level
Authors: Narasimhan Lakshmi , Basupi G. 
Published: May 2023

Abstract

Predicting Freshman student’s aptitude for computing is critical for researchers to understand the underlying aptitude for programming. Dataset out of a questionnaire taken from various Senior students in a high school in the city of Kanchipuram, Tamil Nadu, India was used, where the questions related to their social and cultural backgrounds and their experience with computers. Several hypotheses were also generated. The datasets were analyzed using three machine learning algorithms namely, Back-propagation Neural Network (BPN) and Recurrent Neural Network (RNN) (and its variant, Gated Recurrent Network (GNN)) with K-Nearest Neighbor (KNN) used as the clas-sifier. Various models were obtained to validate the underpinning set of hypotheses clusters. The results show that the BPN model achieved a high degree of accuracies on various metrics in predicting Freshman student’s aptitude for computer programming.