bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validierung der deutschen Version des Fear-Avoidance Beliefs Questionnaire (FABQ-D) für Patient*innen mit Schulterbeschwerden
Authors: Pagels Larissa , Lüdtke Kerstin , Schäfer Axel 
Published: January 2023

Zusammenfassung
Hintergrund
Mit einer Prävalenz von bis zu 30 % sind Schulterbeschwerden das dritthäufigste muskuloskeletale Symptom weltweit. Sowohl die Entstehung als auch der Verlauf wird durch psychosoziale Faktoren, z. B. bewegungsbezogene Angst, beeinflusst. Eines der international gängigsten Messinstrumente zur Erhebung der bewegungsbezogenen Angst ist der Fear-Avoidance Beliefs Questionnaire (FABQ).

Ziel der Arbeit
Untersuchung der Reliabilität (interne Konsistenz) und Validität (Struktur‑, Konstrukt- und prädiktive Validität) des FABQ‑D in einer Population mit Schulterbeschwerden.

Material und Methoden
Im Rahmen einer multizentrischen Querschnittsstudie wurden Proband*innen mit Schulterschmerzen eingeschlossen. Es wurden neben den Angst-Vermeidungs-Überzeugungen die Schmerzintensität, die subjektive Beeinträchtigung im täglichen Leben sowie die Kinesiophobie erfasst. Hierzu dienten der FABQ‑D, die numerische Rating-Skala (NRS), der Shoulder Pain and Disability Index (SPADI) und die Tampa Scale for Kinesiophobia (TSK-GV).

Ergebnisse
Insgesamt konnten 49 Proband*innen (24 Frauen und 25 Männer) mit einem mittleren Alter von 41,8 (SD = 12,8) eingeschlossen werden. Die deskriptive Auswertung auf Itemebene zeigte eine gute interne Konsistenz des FABQ‑D (Cronbachs α = 0,88). Die Homogenität der Subskalen variierte dabei stark (Loevingers H = 0,66–0,9). Die Korrelationsberechnungen ergaben keine deutliche Konvergenz des FABQ‑D mit der TSK-GV (r = 0,3501; p = 0,0137). Es konnte eine Divergenz zu den Konstrukten der Messinstrumente NRS (r = 0,1818; p = 0,2112) und SPADI (r = 0,4415; p = 0,0015) bestätigt werden. Die Hypothesentestung ergab 42,87 % angenommene Hypothesen und somit keine gute Konstruktvalidität. Es konnte ein signifikanter gemeinsamer Einfluss des FABQ‑D und der TSK-GV auf die Beschwerdedauer festgestellt werden (R2 = 0,3652; p ≤ 0,0001). Zudem konnte aufgezeigt werden, dass die größten Einflussfaktoren für einen hohen FABQ-D-Wert die funktionellen Beeinträchtigungen (SPADI) und die Beschwerdedauer bilden (R2 = 0,3066; p = 0,0002). Die Subgruppenanalyse zeigte einen signifikant höheren Wert des FABQ‑D bei den älteren Proband*innen (40- bis 65-jährig; t = 3,8084/df = 47, p = 0,0002).

Diskussion
Der FABQ‑D ist ein reliables Messinstrument. Die Konstruktvalidität konnte nur eingeschränkt bestätigt und sollte in zukünftigen Studien weiter untersucht werden. Die Ergebnisse dieser Studie sind vergleichbar mit vorangegangenen Validierungsstudien in anderen Populationen. Der FABQ‑D kann somit als Messinstrument zur Erhebung der bewegungsbezogenen Angst bei Schulterpatient*innen verwendet werden.
Quantitative extensions of reaction systems based on SOS semantics
Authors: Brodo Linda , Bruni Roberto , Falaschi Moreno , Gori Roberta , Levi Francesca , Milazzo Paolo 
Published: January 2023

AbstractReaction systems (RSs) are a successful natural computing framework inspired by chemical reaction networks. A RS consists of a set of entities and a set of reactions. Entities can enable or inhibit each reaction and are produced by reactions or provided by the environment. In this paper, we define two quantitative variants of RSs: the first one is along the time dimension, to specify delays for making available reactions products and durations to protract their permanency, while the second deals with the possibility to specify different concentration levels of a substance in order to enable or inhibit a reaction. Technically, both extensions are obtained by modifying in a modular way the Structural Operational Semantics (SOS) for RSs that was already defined in the literature. Our approach maintains several advantages of the original semantics definition that were: (1) providing a formal specification of the RS dynamics that enables the reuse of many formal analysis techniques and favours the implementation of tools, and (2) making the RS framework extensible, by adding or changing some of the SOS rules in a compositional way. We provide a prototype logic programming implementation and apply our tool to three different case studies: the tumour growth, the Th cell differentiation in the immune system and neural communication.
Competition of deltaic feeder systems reflected by slope progradation: a high-resolution example from the Late Miocene-Pliocene, Drava Basin, Croatia
Authors: Špelić Marko , Kovács Ádám , Saftić Bruno , Sztanó Orsolya 
Published: January 2023

AbstractThe thick Lake Pannon sedimentary record provides insights into the downdip and lateral development of stratigraphic surfaces through the analysis of the basin-scale clinoform progradation. The clinoform architecture from the eastern part of the Drava Basin (Pannonian Basin System) was interpreted to reflect the base-level changes. A major downlap surface interpreted as a flooding event followed by rejuvenation of slope progradation was recognized on 2D seismic sections. Detailed 3D seismic interpretation combined with well data revealed that the large sigmoidal and the overlying small oblique clinoform sets that downlap the large one only apparently produce the geometry of a maximum flooding surface. Instead, the 3D mapping revealed the influence of two competing slope systems arriving from the north and northwest. Lateral switching of sediment input, similar to many recent deltaic systems. e.g., Danube and Po rivers led to the variability of stratigraphic surfaces, lithology, and thickness, which resulted in non-uniform shelf-edge migration. These observations were supported by forward stratigraphic modeling simulating different scenarios, which led to the generation of the depositional architecture with an apparent maximum flooding surface. This study also implies the potential pitfalls in basin analysis based only on scarce 2D seismic and emphasizes the role of lateral variations in sediment input controlling the depositional architecture.
A pilot randomized controlled trial evaluating outdoor community walking for knee osteoarthritis: walk
Authors: Drummen S. J. J. , Balogun S. , Lahham A. , Bennell K. , Hinman R. S. , Callisaya M. , Cai G. , Otahal P. , Winzenberg T. , Wang Z. , Antony B. , Munugoda I. P. , Martel-Pelletier J. , Pelletier J. P. , Abram F. , Jones G. , Aitken D. 
Published: January 2023

Abstract

Objectives

To determine the feasibility of a randomized controlled trial (RCT) examining outdoor walking on knee osteoarthritis (KOA) clinical outcomes and magnetic resonance imaging (MRI) structural changes.

Method
This was a 24-week parallel two-arm pilot RCT in Tasmania, Australia. KOA participants were randomized to either a walking plus usual care group or a usual care control group. The walking group trained 3 days/week. The primary outcome was feasibility assessed by changes being required to the study design, recruitment, randomization, program adherence, safety, and retention. Exploratory outcomes were changes in symptoms, physical performance/activity, and MRI measures.

Results
Forty participants (mean age 66 years (SD 1.4) and 60% female) were randomized to walking (n = 24) or usual care (n = 16). Simple randomization resulted in a difference in numbers randomized to the two groups. During the study, class sizes were reduced from 10 to 8 participants to improve supervision, and exclusion criteria were added to facilitate program adherence. In the walking group, total program adherence was 70.0% and retention 70.8% at 24 weeks. The walking group had a higher number of mild adverse events and experienced clinically important improvements in symptoms (e.g., visual analogue scale (VAS) knee pain change in the walking group: − 38.7 mm [95% CI − 47.1 to − 30.3] versus usual care group: 4.3 mm [− 4.9 to 13.4]).

Conclusions
This study supports the feasibility of a full-scale RCT given acceptable adherence, retention, randomization, and safety, and recruitment challenges have been identified. Large symptomatic benefits support the clinical usefulness of a subsequent trial.

Trial registration number
12618001097235.

Key Points• This pilot study is the first to investigate the effects of an outdoor walking program on knee osteoarthritis clinical outcomes and MRI joint structure, and it indicates that a full-scale RCT is feasible.• The outdoor walking program (plus usual care) resulted in large improvements in self-reported knee osteoarthritis symptoms compared to usual care alone.• The study identified recruitment challenges, and the manuscript explores these in more details and provides recommendations for future studies.
The effect of agroforestry farming on wood quality and timber industry and its supportation by Horizon 2020
Authors: Báder Mátyás , Németh Róbert , Vörös Ágnes , Tóth Zsolt , Novotni Adrienn 
Published: January 2023

AbstractOne of the goals of the European Union’s agroforestry plans is to alleviate the shortage of timber in Europe caused by the growing demand for hardwoods and the declining import of tropical timber. The study shows which tree species can be considered in agroforestry systems in Europe, and which of them can be used as raw material for the wood industry and what quality of wood can be produced in agroforestry systems. Since 2005, the European Union has been officially encouraging farmers to plant the crops in an agroforestry system and parallel try to produce trunks for high quality timber. By analysing the current economic developments of the European Union, especially Horizon 2020, our study provides an overview of what can be expected by the participants of the agroforestry sector and the related primary wood industry in the European Union now and in the future. In addition to the distribution analysis, indices describing projects have also been created. Rank correlation was used to examine the relationship between them. Possible decision mechanisms were also outlined using a custom-built expert software system.
Genebanking plant genetic resources in the postgenomic era
Authors: Aubry Sylvain 
Published: January 2023

AbstractGenebanking, the process of preserving genetic resources, is a central practice in the modern management of crop genetics, especially for the species used for food and agriculture. Closely interrelated networks of local, national and global actors are responsible for ex situ conservation. They all seek to make plant genetic resources accessible for all and now face new challenges arising from digitisation. Plant sciences are entering the postgenomic era, moving fast from initially providing a single reference genome for each species (genomics), to harnessing the extent of diversity within crop species (pangenomics) and among their relatives (referred to as postgenomics). This paper describes the extent to which ex situ collections have already undergone a digital shift, or are planning to do so, and the potential impact of this postgenomic-induced dematerialisation on the global governance of plant genetic resources. In turn, digitising material (seed) collection changes the relationship between genebanks and genomic databases. Comprehensive genomic characterisation of genebank accessions is ongoing, and I argue here that these efforts may provide a unique opportunity for genebanks to further embrace the moral, ethical and ultimately political principles on which they were built. Repurposing genebanks as decentralised digital biocentres could help relocate capabilities and stewardship over genetic resources. Empowering local farmers by providing access, promoting the use and unlocking benefits from state-of-the-art tools of modern plant breeding may allow bridging the breeding divide. However, to accomplish such a paradigm shift, genebanks require a strong political mandate that must primarily originate from the access and benefit-sharing framework. Only so may the global challenges associated with the loss of biodiversity and food insecurity be addressed.
Sexual Stimuli Cause Behavioral Disinhibition in Both Men and Women, but Even More So in Men
Authors: Wiemer Julian , Kurstak Steffen , Sellmann Florian , Lindner Kerstin 
Published: January 2023

AbstractIn our society men are considered more impulsive than women, especially in the violent and sexual domain. This correlation of sex and impulsivity might trace back to enhanced male impulsivity in general or a domain specific effect of emotions on impulsivity. The evidence for sex differences in the interaction of emotional or sexual stimuli and impulsivity has been relatively inconclusive so far. In this study, we investigated the effects of various emotional stimuli on responsivity in a Go/No-Go task. Participants had to respond quickly to a visual cue and withhold their response to another visual cue, while different emotional pictures were presented in the background, including sexual stimuli, non-sexual positive stimuli and negative stimuli. Both men (N = 37) and women (N = 38) made most commission errors in the sexual condition, indicating a disinhibiting effect in both genders. On top of this, men made even more commission errors than women, specifically in the sexual condition and not in other conditions. Men rated sexual stimuli as more positive, but did not differ from women in arousal ratings and pupil dilation. These findings may partly indicate increased impulsive behavior under sexual arousal in men, most likely driven by enhanced approach motivation due to more positive value but not higher arousal of sexual stimuli. The results are consistent with the theory of evolutionarily based concealment of sexual interest in women.
Priming effect depending on land use and soil types in a typical semi-arid landscape in Kenya
Authors: Mganga Kevin Z. , Rolando José L. , Kalu Subin , Biasi Christina , Karhu Kristiina 
Published: January 2023

AbstractAddition of labile carbon (C) inputs to soil can accelerate or slow down the decomposition of soil organic matter (SOM), a phenomenon known as priming effect (PE). However, the magnitude and direction of PE is often difficult to predict, consequently making its relationship with labile C inputs and nutrient availability elusive. To assess this relationship, we added 13C labelled glucose (corresponding to 50% of initial soil microbial biomass C) to two soil types (Vertisol and Acrisol) with different concentrations of available N and from four land use systems (agricultural, pasture, grassland and shrubland). Parallel laboratory incubations i.e. short-term (6 days) and long-term (6 months), were set up to determine the effect of land use and soil type (N availability) on PE. Addition of labelled glucose in solution led to the retardation of SOM mineralization (negative PE) in both soil types and across all land use systems. This is attributed to preferential substrate utilization characterized by the higher mineralization of added glucose. Land use systems and soil types with higher N-availability displayed weaker negative PE, which is in line with the stoichiometric decomposition theory. In conclusion, our study demonstrate that N-availability plays a major role in determining mineralization of labile C inputs, magnitude and direction of PE in the studied dryland soils and land use systems. The fact that 15–27% of the added 13C remained in the soil at the end of the 6 months incubation and PE was negative, indicates that continuous labile C inputs could contribute to C immobilization and stabilization in these semiarid soils. Moreover, 13C glucose remaining in soils after 6 months in semi-natural pastures was comparable to those under natural grassland and shrubland systems especially in Acrisols. This demonstrates that incorporation and maintaining a perennial cover of native pastures has the potential to increase C sequestration in African semi-arid agricultural soils and landscapes.
Polynomial stochastic dynamical indicators
Authors: Vasile Massimiliano , Manzi Matteo 
Published: January 2023

AbstractThis paper introduces three types of dynamical indicators that capture the effect of uncertainty on the time evolution of dynamical systems. Two indicators are derived from the definition of finite-time Lyapunov exponents, while a third indicator directly exploits the property of the polynomial expansion of the dynamics with respect to the uncertain quantities. The paper presents the derivation of the indicators and a number of numerical experiments that illustrates the use of these indicators to depict a cartography of the phase space under parametric uncertainty and to identify robust initial conditions and regions of practical stability in the restricted three-body problem.
Differential testing for machine learning: an analysis for classification algorithms beyond deep learning
Authors: Herbold Steffen , Tunkel Steffen 
Published: January 2023

AbstractDifferential testing is a useful approach that uses different implementations of the same algorithms and compares the results for software testing. In recent years, this approach was successfully used for test campaigns of deep learning frameworks. There is little knowledge about the application of differential testing beyond deep learning. Within this article, we want to close this gap for classification algorithms. We conduct a case study using Scikit-learn, Weka, Spark MLlib, and Caret in which we identify the potential of differential testing by considering which algorithms are available in multiple frameworks, the feasibility by identifying pairs of algorithms that should exhibit the same behavior, and the effectiveness by executing tests for the identified pairs and analyzing the deviations. While we found a large potential for popular algorithms, the feasibility seems limited because, often, it is not possible to determine configurations that are the same in other frameworks. The execution of the feasible tests revealed that there is a large number of deviations for the scores and classes. Only a lenient approach based on statistical significance of classes does not lead to a huge amount of test failures. The potential of differential testing beyond deep learning seems limited for research into the quality of machine learning libraries. Practitioners may still use the approach if they have deep knowledge about implementations, especially if a coarse oracle that only considers significant differences of classes is sufficient.
Pharmacological heat-shock protein inducers and chemical chaperones inhibit upregulation of interleukin-8 by oxidized phospholipids
Authors: Hellauer Klara , Oskolkova Olga V. , Gesslbauer Bernd , Bochkov Valery 
Published: January 2023

AbstractOxidised phospholipids such as oxidised palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) are increasingly recognised as danger-associated molecular patterns (DAMPs) inducing cyto- and chemokines. The pathological impact of oxidised phosphatidylcholine in vivo has been demonstrated in several animal models, as well as in human association studies. In this work, we have tested a number of small molecules with known or potential anti-inflammatory properties for their ability to inhibit secretion of interleukin-8 by OxPAPC-treated endothelial cells. Six compounds capable of inhibiting the induction of IL-8 were selected. Analysis of gene expression has shown that all these substances reduced the OxPAPC-induced elevation of IL-8 mRNA but potentiated induction of heat-shock proteins (HSPs). We further found that drug-like HSP inducers also prevented the induction of IL-8 by OxPAPC. Similar inhibitory action was demonstrated by two chemical chaperones, which stabilise proteins through physicochemical mechanisms thus mimicking effects of HSPs. Our data suggest that proteostatic stress plays an important mechanistic role in the pro-inflammatory effects of OxPAPC and that stabilisation of proteome by overexpression of HSPs or by chemical chaperones can reduce the pro-inflammatory effects of OxPLs.
Meibomian gland secretion quality association with ocular parameters in university students during COVID- 19 restrictions
Authors: Garcia-Queiruga Jacobo , Pena-Verdeal Hugo , Sabucedo-Villamarin Belén , Giraldez Maria J. , Garcia-Resua Carlos , Yebra-Pimentel Eva 
Published: January 2023

Abstract
Purpose
To determine if the Meibomian Gland (MG) secretion quality is associated with symptoms of ocular discomfort, hours of Video Display Terminals (VDT) use, eyelid margin abnormalities, conjunctival hyperemia, and Meibomian Gland Loss Area (MGLA) in a sample of university students.

Methods
An online survey that included an Ocular Surface Disease Index (OSDI) questionnaire and an extra question about hours of VDT use recruited an initial sample of 183 participants. Only 120 participants that fulfilled the inclusion criteria were scheduled for a battery of ocular surface and MG specific exam. The tests include: 1) meibometry, 2) slit lamp exploration of eyelid margin abnormalities (irregularity, hyperemia and MG orifices plugging), MG secretion quality and conjunctival hyperemia, and 3) Meibography.

Results
Significant positive correlations between the MG secretion quality and eyelid margin hyperemia, MG orifices plugging, MGLA, nasal conjunctival hyperemia, and temporal conjunctival hyperemia (Spearman Rho; all r>0.186, p<0.042) were found. Multivariate regression found association between OSDI with hours of VDT use (B=0.316, p=0.007), and eyelid hyperemia (B=0.434, p≤ 0.001). A statistical association between MG secretion quality and eyelid margin hyperemia, MG orifices plugging, MGLA and conjunctival hyperemia (Fisher’s exact; all p<0.039) were found. Multivariate regression found association between MG secretion quality with MG orifices plugging (B=0.295, p=0.004) and meibometry (B=-0.001, p=0.029).

Conclusion
Participants with higher values in MG secretion quality have higher values in eyelid margin hyperemia, MG plugging, MGLA, and conjunctival hyperemia. No direct relationship between MG secretion quality and hours of VDT use or OSDI were found.