bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Foreign Direct Investment (FDI), Institutional Performance and Scientific Innovations on Environmental Degradation: Evidence from OIC Countries
Authors: Khan Shafqat Mehmood , Rehman Saif-ur- , Fayyaz Sana 
Published: April 2023

The aim of this study is to examine the effect of foreign direct investment (FDI), institutional performance and scientific innovations on environmental degradation (ecological footprints) in selected OIC member countries. In this study, panel data analysis of selected OIC lower-middle income member countries over the period of 2000-2022 has been carried out. Cross-section dependance test has been done to check if there is cross-section dependence present among the variables and then second generation unit rot test has been employed to test the level of stationarity. Upon the recommendation of these tests, Pool Mean Group (PMG) has been applied to investigate the long run associations among the dependent and independent variables. The findings of this study show that FDI has significant negative impact on ecological footprint and has been acting as environmentally friendly in lower-middle countries. Scientific innovations has significant positive impact on ecological footprint whereas Institutional performance has positive impact on ecological footprint has significant negative impact in high lower-middle income countries. Furthermore, the study has trade openness has positive and significant impact on ecological footprint and GDP per capita has insignificant impact on ecological footprint.
Pembangunan dan Perlindungan Kebudayaan
Authors: Bahar DR. Saafroedin 
Published: April 2023

The term "development" is not neutral. It is full of value, either ideology, political or cultural values. It means that cultural consideration has the same importance as ideology and political considerations. A balance and consolidated human rights concepts between civil and political rights and economic, social and cultural rights have become the mainstream of development discourse. Hence, when all human rights instruments should be comprehended and justified based on a non-discrimination principle, without differentiation based on race, ethnic, religion or group, simultaneously it should also give opportunity to the fact that culturally human beings are consisted of different anthropological community with different cultures. Each has the right to develop and look after its particular cultural values and institution. This cultural right should be protected by the State in general and by the Government in particular.
Instrumen Internasional Terkait Hak Asasi Orang dengan Masalah Kejiwaan
Authors: Maramis Albert 
Published: April 2023

Tulisan ini membahas tentang aturan-aturan yang ada di tingkat internasional terkait masalah ODMK. Peran instrumen internasional HAM diperlukan dalam mendukung perlindungan HAM bagi ODMK karena kelompok ini termasuk yang paling rentan. Mereka sering dihadapkan pada keadaan yang tidak memungkinkan untuk mempertahankan hak-haknya sehingga dengan mudah mengalami eksploitasi, penghinaan, dan pelanggaran hak-hak dasar. Tulisan ini juga menyampaikan saran agar para pembuat kebijakan di Indonesia benar-benar memperhatikan keberadaan aturan-aturan internasional tersebut.
Pembangunan Sistem Kesehatan Jiwa di Indoneisa
Authors: Viora Eka 
Published: April 2023

Tulisan ini mengupas sejarah perlindungan terhadap ODMK. Dalam catatan sejarah, ternyata kolonial Belanda telah meletakkan dasar- dasar hukum bagi penanganan ODMK di Hindia Belanda. Pada 30 Desember 1865 dikeluarkan Koninlijk Besluit (Keputusan Kerajaan) dan pada 14 Mei 1867 dikeluarkan Keputusan Gubernur Jenderal untuk dibangunnya rumah sakit jiwa di Hindia Belanda. Atas dasar itulah berdiri beberapa rumah sakit jiwa yang hingga kini masih menjadi pilar bagi penanganan ODMK di Indonesia. Antara lain RSJ Bogor pada 1876, RSJ Lawang pada 1902, RSJ Solo pada 1919, RSJ Magelang pada 1923, RSJ Jakarta pada 1924, serta RSJ Surabaya dan RSJ Semarang pada 1929. Hingga 1940 terdapat 16 RSJ di 16 provinsi. Namun, pelayanan kesehatan jiwa pada saat itu masih san- gat tertutup, bahkan mirip seperti penjara (custodial care). Dasar hukumnya adalah “het Reglemen op het Krankzinnigenwezen” (STBL 1897 No. 54). Yang menarik adalah bahwa salah satu pertimbangan kuat dalam suatu keputusan kerajaan adalah banyaknya pasien gangguan jiwa yang didapat dalam satu survei sehingga harus disatukan dalam satu fasilitas pTulisan ini membahas tentang pembangunan sistem kesehatan jiwa di Indonesia. Sistem pelayanan kesehatan jiwa yang tersedia di Indonesia saat ini masih didominasi oleh pelayanan kesehatan jiwa di institusi rumah sakit jiwa (RSJ). Kondisi ini menyebabkan RSJ di Indonesia bukan lagi berfungsi sebagai pelayanan tersier atau pusat rujukan, melainkan sebagai puskesmas “besar” karena semua penderita gangguan jiwa yang sebetulnya bisa dilayani di puskesmas dan RSU kabupaten/kota tetap ditangani di RSJ. Tulisan ini menekankan perlunya komitmen kuat dari segenap pihak, yakni para perencana, manajer, klinikus, dan lain-lain, untuk mereformasi pelayanan kesehatan jiwa di Indonesia. Agar benar-benar efektif, Indonesia perlu mengembangkan sebuah sistem layanan kesehatan jiwa berbasis masyarakat yang diberikan oleh keluarga, kelompok masyarakat, serta kader atau pekerja sukarela.rawatan dan tidak “berkeliaran” di masyarakat.
Apresiasi Hak Penyandang Disabilitas dalam Penyelenggaraan Layanan Publik di Indonesia
Authors: Daming Saharuddin 
Published: April 2023

Dalam era globalisasi yang ditan- dai dengan iklim kompetisi yang semakin ketat, tantangan utama peradaban manusia, bukan lagi isu perang dingin antar blok pertahanan, melainkan isu kemiskinan, konflik etnis, penguatan demokrasi dengan segala resikonya, serta globalisasi ekonomi termasuk perubahan peran dan interaksi antara negara, pasar, dan masyarakat madani. Selain itu, aspi- rasi dan tuntutan masyarakat juga semakin meningkat akibat semakin terbukanya informasi dan meningkatnya kesadaran hak- hak warga negara.
Pemenuhan HAM dan Penghapusan Diskriminasi terhadap Orang Dengan Kusta dan Keluarganya
Authors: Prasetyo Stanley Adi 
Published: April 2023

Di Indonesia penyakit kusta sejak pertengahan 2000 sebetulnya dinyatakan telah tereliminasi. Tapi menurut laporan WHO pada 2008 Indonesia masih menempati peringkat ke-3 sebagai negara penyumbang penderita baru. Pada 2008 jumlah penderita baru yang ditemukan berjumlah 17.441 orang. Posisi ini menyusul India sebagai peringkat pertama dan Brazil sebagai peringkat kedua negara dengan jumlah penderita kusta terbanyak di dunia.
Eksplanasi Teoritik untuk Kebijakan Pro-Kesejahteraan di Indonesia
Authors: Mulyana Asep 
Published: April 2023

Artikel ini berangkat dari fenomena baru yang ditandai dengan munculnya kebijakan pemerintah yang fokus pada peningkatan kesejahteraan warga miskin (welfare policy). Kelompok warga miskin yang selama ini mengalami eksklusi, baik secara ekonomi, sosial maupun politik, telah menjadi subjek penting dalam kebijakan sosial di Indonesia. Pemerintah pusat diikuti beberapa pemerintah daerah di Indonesia membangun kebijakan-kebijakan sosial yang berpihak pada peningkatan kesejahteraan warga miskin. Namun demikian, hingga kini belum ada eksplanasi teoritik yang dapat menjelaskan secara memadai fenomena tersebut. Oleh karena itu, artikel ini bertendensi untuk menemukan kerangka teoritik yang mampu memberi eksplanasi yang memuaskan atas fenomena tersebut.Artikel ini menggambarkan kerangka kerja yang disusun oleh Jayasuriya (2006) untuk menjelaskan fenomena di atas. Menurut Jayasuriya, kebijakan prokesejahteraan di negara berkembang lahir atas kebutuhan rezim neoliberalisme global untuk mengintegrasikan kewargaan (citizenship) ke dalam pasar. Kebijakan pro-kesejahteraan difokuskan untuk meningkatkan kapabilitas masyarakat miskin agar selaras dengan kebutuhan pasar. Karena dibangun di atas fondasi kewargaan pasar (market citizenship) semacam itu, dan bukan melalui pembentukan pakta sosial yang berlangsung dalam negosiasi yang alot antara negara, warga, dan pasar, maka kebijakan prokesejahteraan di Indonesia menunjukkan watak yang antipolitik dan menonjolkan peran agen yang aktif (elit populis). Jauh sebelum wacana ini berkembang, muncul dilema-dilema di mana demokrasi dan kesejahteraan dinilai tidak selalu berdampingan. Kesejahteraan yang pernah dicapai oleh rejim-rejim developmentalisme di Asia Timur menunjukkan bahwa kesejahteraan dapat dicapai melalui tangan besi. Artikel ini diharapkan memberikan kontribusi teoritik baru tentang dilema yang sama pasca-rezim developmentalisme.
Effects of Hydrogel on Physical and Chemical Properties of Soil
Authors: Patel Kamal Kishor , Shah Ajay Kumar , Latare A. M. 
Published: April 2023

This experiment was performed at the Rajiv Gandhi South Campus, Barkachha (BHU) Mirzapur, as a pot culture study, from November 2018 to March 2019–20. This experiment is a completely randomised design, taking three replications with six treatments, i.e., T1: Control, T2: 5 g kg-1 Hydrogel, T3: 10 g kg-1 Hydrogel, T4: 15 g kg-1 Hydrogel, T5: 20 g kg-1 Hydrogel, and T6: 25 g kg-1 Hydrogel. The soil was incubated with different doses of hydrogel for 120 days. The samples were collected after incubation, processed in a laboratory, and analysed for physical and chemical properties of soil. The results demonstrated that the use of hydrogel had a significant impact on the various soil properties, particularly the water holding capacity and bulk density of the soil. Other soil properties that were significantly influenced were particle density, porosity, electrical conductivity, soil available nitrogen, phosphorus, potassium, calcium, magnesium, and sulfur. However, the application of hydrogel did not influence the pH of soil or the organic carbon content of soil. The application of hydrogel at a rate of 25 g kg1 showed the highest values of available N, P, K, and S content in soil as well as the water holding capacity. In some soil properties, the treatment containing 25 g kg-1 hydrogel was found to be statistically equivalent to that containing 20 g kg-1 hydrogel.
Integration of Extracellular Matrices into Organ‐on‐Chip Systems
Authors: Kutluk Hazal , Bastounis Effie E. , Constantinou Iordania 
Published: April 2023

AbstractThe extracellular matrix (ECM) is a complex, dynamic network present within all tissues and organs that not only acts as a mechanical support and anchorage point but can also direct fundamental cell behavior, function, and characteristics. Although the importance of the ECM is well established, the integration of well‐controlled ECMs into Organ‐on‐Chip (OoC) platforms remains challenging and the methods to modulate and assess ECM properties on OoCs remain underdeveloped. In this review, current state‐of‐the‐art design and assessment of in vitro ECM environments is discussed with a focus on their integration into OoCs. Among other things, synthetic and natural hydrogels, as well as polydimethylsiloxane (PDMS) used as substrates, coatings, or cell culture membranes are reviewed in terms of their ability to mimic the native ECM and their accessibility for characterization. The intricate interplay among materials, OoC architecture, and ECM characterization is critically discussed as it significantly complicates the design of ECM‐related studies, comparability between works, and reproducibility that can be achieved across research laboratories. Improving the biomimetic nature of OoCs by integrating properly considered ECMs would contribute to their further adoption as replacements for animal models, and precisely tailored ECM properties would promote the use of OoCs in mechanobiology.
Designing formative assessments to improve anatomy exam performance
Authors: Kingston Amanda K. , Garofalo Evan M. , Cardoza Kristinmae , Fisher Rebecca E. 
Published: April 2023

AbstractFormative assessments are primarily used as a tool to gauge learning throughout an anatomy course. They have also been demonstrated to improve student mastery and exam performance, although the precise nature of this relationship is poorly understood. In this study, it is hypothesized that formative assessment questions targeting higher cognitive levels, integrating topics from multiple lessons, and including visuospatial elements will increase student exam performance. Formative and summative questions provided to students during the Clinical Anatomy block at the University of Arizona College of Medicine—Phoenix between 2015 and 2018 were assessed for cognitive level, integration of targeted learning objectives, and presence or absence of visuospatial elements. These variables were entered into a hierarchical linear model along with demographic variables for each cohort to assess the relationships between these variables and cohort performance on exam questions. The best predictor of exam performance was the inclusion of constituent learning objectives within the formative assessment. Additionally, students performed better on exam questions with visuospatial elements when the targeted learning objectives were also associated with visuospatial elements on the formative assessment. Surprisingly, the cognitive level of formative questions and the integration of learning objectives within them were not correlated with student exam performance. This study demonstrates the importance of including a broad range of topics in formative assessments and highlights a potential benefit of adopting consistent question formats for formative assessments and exams.
The Future Workforce of the Environmental Laboratory
Authors: Adams Hunter , Morin Erin , Holloway Nicole , Cottrell Ashley , Thames Becky , Gillis Leah , Wangsness Kathryn , Loudon Jennifer , Wright Sarah 
Published: April 2023

Key TakeawaysThe environmental laboratory workforce is aging out and needs creative solutions to recruit and retain skilled staff to perform physical, microbial, chemical, and radiological tests.There are immediate needs for chemists to work in radiochemistry and to conduct analyses for per‐ and polyfluoroalkyl substances and other contaminants of emerging concern.Promoting the water and wastewater industry and developing the industry workforce require education through public outreach, internships, fellowships, and citizen science.
Science communication from a course‐based undergraduate research experience
Authors: Teter Ken 
Published: April 2023

AbstractCourse‐based undergraduate research experiences (CUREs) provide an efficient mechanism to provide many students with an original research project. CUREs often culminate in a capstone poster presentation, but reports on these classes usually focus on the preparation and execution of the project rather than communication of the results. This article summarizes a CURE‐associated research seminar that focuses on developing the communication and interpersonal skills required for the production and presentation of a conference poster. The class is designed to provide students with the tools and confidence for effective communication of their research. From the two class offerings to date, the 18 participating students have received five awards from 19 conference presentations.
Long‐term outcomes in patients with chronic lymphocytic leukemia treated with ibrutinib: Focus on hypertension and cardiovascular toxicity
Authors: Gordon Max J. , Jones Jade E. , George Binsah , Peterson Christine , Burger Jan A. , Jain Nitin , Keating Michael , Wierda William G. , Durand Jean‐Bernard , Ferrajoli Alessandra 
Published: April 2023

AbstractBackgroundContinuous ibrutinib administration is needed to maintain efficacy in patients with chronic lymphocytic leukemia (CLL) and, as such, long‐term toxicity is a concern. The authors report the 5‐year follow‐up of patients with CLL who received treatment with ibrutinib with a focus on hypertension and cardiovascular toxicities.MethodsPatient characteristics were assessed, including blood pressure, cardiovascular disease, disease progression, and death. Univariate logistic regression analysis assessed the relation of patient characteristics and the development of new or worsened hypertension. The incidence of hypertensive outcomes was evaluated using competing risk. Survival was estimated using the Kaplan–Meier method.ResultsThree hundred patients with CLL who were treated with ibrutinib on clinical trials were included. The median patient age at study enrollment was 65 years (range, 29–83 years). Seventy percent of patients were men, and 88% were Caucasian. Sixty‐nine percent of patients had hypertension at baseline, and 47% were on antihypertensive medication. Eighty‐eight percent had relapsed or refractory CLL. New‐onset and worsening hypertension were common, occurring in 68.5% and 38% of patients, respectively. Systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥100 mm Hg was observed in 16.9% of patients. Hypertension was reversible after ibrutinib discontinuation. Older age, male sex, tobacco use, and chronic kidney disease were associated with ibrutinib‐related hypertension. Baseline hypertension was not associated with major adverse cardiovascular events in ibrutinib‐treated patients nor with event‐free or overall survival.ConclusionsHypertension is a common toxicity in patients with CLL who receive ibrutinib but is manageable in most patients. Other than chronic kidney disease, baseline cardiovascular disease did not affect ibrutinib‐related hypertension nor was hypertension associated with major adverse cardiovascular events or survival.Plain Language Summary

Ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia.

Ibrutinib is a well tolerated therapy, however hypertension can develop or worsen in patients receiving ibrutinib and other cardiovascular events are significant challenges to the use of this drug.

This may be particularly true in patients with heart disease.

Short‐term side effects may worsen heart disease, but the long‐term impact is unknown.

The long‐term results of ibrutinib on heart disease and hypertension are described.
Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults
Authors: Adams Jenna N. , Márquez Freddie , Larson Myra S. , Janecek John T. , Miranda Blake A. , Noche Jessica A. , Taylor Lisa , Hollearn Martina K. , McMillan Liv , Keator David B. , Head Elizabeth , Rissman Robert A. , Yassa Michael A. 
Published: April 2023

AbstractIntroductionWe tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume.MethodsThirty‐two, non‐demented older adults with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ]42/Aβ40, phosphorylated tau [p‐tau]181, total tau [t‐tau]), positron emission tomography (PET; 18F‐florbetapir), high‐resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed. We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI).ResultsBiomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely associated with RI, whereas CA1 and BA35 volume were related to both RI and overall memory recall. AD pathology was associated with reduced BA35, CA1, and subiculum volume. DG volume and Aβ were independently associated with RI, whereas CA1 volume mediated the relationship between AD pathology and RI.DiscussionIntegrity of distinct hippocampal subfields demonstrate differential relationships with pathology and memory function, indicating specificity in vulnerability and contribution to different memory processes.
Lower lip reconstruction using McGregor fan technique with or without depressor anguli oris chimeric flap. Is there a difference in function and aesthetic outcomes?
Authors: Al‐Aroomi Maged Ali , Al‐Worafi Naseem Ali , Zhou Wanhang , Telha Wael , Elayah Sadam Ahmed , Al‐Sharani Hesham Mohamed , Sun Changfu , Qi Zhongzheng 
Published: April 2023

AbstractBackgroundLower lip reconstruction aims to maintain facial subunit function and aesthetics. We present a minor modification of the McGregor flap technique, in which depressor anguli oris (DAO) muscle is separately elevated as a chimeric flap together to investigate the outcomes for reconstructing lower lip defects using various functional parameters.MethodsThe study included patients who underwent surgical repair of lower lip defects using a McGregor fan flap with or without DAO muscle chimeric flap between January 2018 and May 2021. The patients were divided into our modified technique with DAO chimeric flap (study group) and conventional McGregor (control group). The primary outcomes were functional evaluation of oral competency, speech intelligibility, and tactile sensation of reconstructed lip outcomes. The functional satisfaction and Patient and Observer Scar Assessment Scale (POSAS) were analyzed.ResultsA total of 20 patients were enrolled (10 patients for each group). Excellent oral competence was present in 12 patients, favorably significant in patients with DAO chimeric flap (n = 8/10, p = 0.018). All patients had intelligible speech with insignificant differences between the two groups. No patients demonstrated differences to light touch from baseline sensation at 1 year. Patients in the study group reported more lip function satisfaction (p = 0.049). The POSAS score indicates satisfaction with the appearance of all patients.ConclusionMcGregor fan technique combined with DAO muscle chimeric flap offers a good choice by maintaining sensory and motor functions. Our minor modification can ensure the integrity of the oral sphincter, leading to improved lower lip function.
Acetylcholine‐sensitive control of long‐term synaptic potentiation in hippocampal CA3 neurons
Authors: Kassab Randa 
Published: April 2023

AbstractA Hebbian form of long‐term potentiation (LTP) is believed to be the basis of memory storage at CA3 recurrent synapses. Abnormalities in CA3 intrinsic connectivity have been related to memory deficits in a variety of neurological disorders. Despite the promise of computational modeling for illuminating the pathogenic implication of connectivity changes, common Hebbian‐based models with preset structural topologies fall short in this regard. Here, I introduce a structure‐independent approach to modeling CA3 network focusing on how LTP shapes CA3 functional connectivity. Network simulations demonstrate that only a small fraction of the active synapses should be potentiated onto engram‐bearing cells for reaching CA3 optimal performance, and that this fraction should be actively regulated at the single‐cell level to maintain precise control over excitatory inputs to and from overlapping engram cells. In light of these findings, I develop a theory suggesting that synaptic potentiation is regulated through extrinsic and intrinsic cellular mechanisms involving the cholinergic modulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors. The theory posits that the progressive increase of acetylcholine release during learning is commensurate with the rate of AMPA receptor trafficking during LTP development and that this dynamics is intended to conceal AMPA receptor potentiation and thereby to propel LTP progression until a target level of potentiation is attained at a restricted number of the active synapses. Functionally, this form of regulation allows encoding and retrieval dynamics to be dictated at the single‐cell level and thereby acts at the cell‐population level as a secondary mechanism complementing dentate gyrus‐mediated pattern separation or compensating for possible deficiencies. Conversely, when this regulation fails, the strength of AMPA receptors and their variability across synapses change over time and lead to pathological states.