bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Using Secang (Caesalpinia secang Linn) Infusion on the Organoleptic Quality of Chicken Sausage
Authors: Ratna Ani Way , Monica Metha , Tani Sri Arnita Abu 
Published: January 2023

This study aims to determine the effect of using Secang infusion (Caesalpinia secang Linn) on the organoleptic quality of chicken sausages and determine the optimal level of adding Secang infusion on the organoleptic quality of chicken sausages. This research was carried out in 30 days at the Laboratory of the Faculty of Animal Husbandry, University of Jambi. This study used a randomized block design (RBD) which consisted of 4 treatments and 30 replications (panelists). The concentration of Secang infusion used was 0%, 5%, 10%, and 15%. The variables observed in this study were the value of organoleptic quality, which included color, aroma, taste, texture, and elasticity. The data obtained were analyzed by analysis of variance (ANOVA). If it had a significant effect, it continued with Duncan's test. The results showed that the use of Secang infusion on chicken sausage had a very significant effect (P<0.01) on color but had no effect (P>0.05) on aroma, taste, texture, and elasticity. The higher the concentration of Secang infusion, the more preferred the sausage color will be. It can be concluded that the processing of chicken sausage with the addition of Secang infusion at 10% and 15% level produced the preferred color of the panelist's preference level compared to the 0% and 5% levels. Still, the addition of Secang in the processing of chicken sausage did not make a difference to the level of preference for aroma, taste, texture, and suppleness.
Memahami Konstruksi Nalar Epistemologi Etnik: Sebuah Kajian Filosofis
Authors: Manurung Elvy Maria , Purwadi Yohanes Slamet , Sugiharto Ignatius Bambang 
Published: January 2023

In the 21st century, due to its incessant auto-criticism, the orientation of science is split into two. On the one hand, the monolythic tendency of positivism -with its physicalistic paradigm- is still prevalent. On the other, the tendency of openess toward the complexity of reality is also thriving. The latter would include the openess toward non physical variables or even toward esoteric experience. At this junction, the concept of<br />ethnoepistemology is worth considering. With regard to this, this article seeks to see the fundamental differences between the universal-scientific epistemology and ethnoepistemology. Ethnoepistemology is examined in terms of its local ontological-worldview, which mostly is spiritual in character. It was found out that the local worldview generates a particular knowledge, with specific logic, method and vocabulary of its own. Complemented with some case-studies, the article comes up with the idea that the mistery of the world can be accessed from many points of view, resulting in different kinds of knowledge. That said, while scientific epistemology is not the only possible one, ethnopistemology can upgrade itself by learning from the work-ethos of scientific epistemology. <br /><br /><strong>Key words:</strong> episteme, worldview, logic, interdependency, holistic, experiential
Business management of Homeomed Sdn. Bhd. – A case study of a local SME
Authors: Syed Syed Ezanee Zulfakhri , Nadarajah Gunalan 
Published: January 2023

Homeopathy is categorized under Traditional and Complimentary Medicine (TCM) and is an underrated business both by the government and the public. There is less support by the government from the perspective of acknowledgement, nationwide publication, and validation on homeopathy as an important complimentary medicine. To escalate the issue further, homeopathy practitioners have been practicing homeopathy in a traditional manner and disconnected with the principles and concepts of business management and administration. Homeomed Sdn. Bhd. (Homeomed) is one of the homeopathy companies; operating in Bukit Beruang, Melaka; they had almost ceased the business few times due to high operational cost and the effects of Covid-19 pandemic. They were experiencing the classical business challenges for SME of having a “bulk business issues” in all aspects of business management due to incompetency or ignorance or both. The main tasks here is to identify the gaps from a business point of view and to propose a few improvement recommendations focusing on operation, marketing, sales, human resource, finance, supply chain and customer service. During the implementations of new business techniques and approaches, main performance indicators such as revenue, number of patients, inquiries and customer satisfaction were measured to reflect Homeomed’s competitiveness. The data collected are analysed and studied for further improvement initiatives. The data collected are analysed and studied for further improvement initiatives. A total of five main problem areas were identified and solutions were implemented in 5 stages with all of it deriving positive outcomes.
ANALISIS SIKAP IBU TENTANG STIMULASI TUMBUH KEMBANG BALITA STUNTING USIA 2-3 TAHUN DI SURAKARTA
Authors: Maulida Luluk Fajria , Maulina Rufidah , Sari Atriany Nilam , Novika Revi Gama Hatta , Wahidah Nurul Jannatul , Nurhidayati Siti 
Published: January 2023

Tahapan perkembangan anak memang sangat menakjubkan, karena pada setiap tahapan perkembangan anak tidak hanya tumbuh secara fisik, tetapi juga secara mental hingga kecerdasannya. Salah satu syarat menuju perkembangan yang optimal adalah sikap orang tua atau pengasuh yang positif. Tujuan penelitian ini adalah mengetahui sikap ibu tentang stimulasi tumbuh kembang balita stunting usia 2-3 tahun di Surakarta. Metode penelitian menggunakan deskriptif analitik dengan pendekatan cross sectional. Penelitian ini dilaksanakan bulan April 2022 di Kelurahan Pasar Kliwon dengan teknik total sampling. Jumlah responden sebanyak 30 orang. Analisis data menggunakan analisis univariat. Hasil penelitian ini diperoleh ibu yang bersikap positif sebanyak 46,7% dan bersikap negatif sebanyak 53,5%. Kesimpulan penelitian ini adalah sebagian besar ibu bersikap negatif terhadap stimulasi tumbuh kembang balita stunting usia 2-3 tahun. Diperlukan pelatihan maupun pendampingan pada keluarga untuk mengoptimalkan stimulasi tumbuh kembang balita.
Bronchoalveolar lavage in pediatric oncohematology
Authors: Krylovetskaya M. A. , Gusarova O. A. , Savosin R. S. , Valiev T. T. , Kuvshinov Y. P. , Grigorievskaya Z. V. , Malikhova O. A. , Tumanyan A. O. 
Published: January 2023

Relevance. Pulmonary lesions of infectious etiology in oncohematological children are common and, in some cases, may be accompanied by a lethal outcome. When pulmonary tissue lesions on the background of hematopoiesis aplasia in the post-chemotherapy period is shown bronchoscopy to determine the genesis of the identified changes.Aim. To determine the diagnostic value of bronchoscopy with BAL in children with oncohematological diseases.Materials and methods. 25 bronchoscopies with BAL were performed on the basis of the endoscopic department of the Research Institute of Pediatric Oncology and Hematology.Results. According to the results of the study in 72% of cases a microbiologic agent was detected. The most frequent pathogens obtained by the results of cultures were Haemophilus parainfluenzae, Streptococcus oralis, Neisseria macacae, Streptococcus peroris and Pseudomonas aeruginosa.Conclusions. Bronchoscopy with BAL in children with blood system tumors is a highly informative method of pathogen detection and determination of the etiological cause of infiltrative-inflammatory changes in the lungs.
Organic Carbon Burial in Constructed Ponds in Southern Sweden
Authors: Ljung Karl , Lin Simon 
Published: January 2023

Small ponds constructed for nutrient retention, biodiversity conservation or recreation also store large amounts of carbon. The potential role of small ponds for carbon storage and greenhouse gas emissions have been highlighted both in the scientific literature and in management plans. The role of small ponds in the global carbon budget is likely significant, but the potential has not been fully explored. Here we present measurements of yearly sedimentary carbon accumulation and carbon stocks in six small, constructed and restored ponds in southern Sweden. The ponds were constructed or restored during the last 20 years primarily for nutrient retention. The sediment cores span the time from the construction of the ponds until today. The ponds had high carbon accumulation, with mean total carbon stocks in the top 6 cm of sediment of 836 g C m
−2
and a yearly mean C accumulation rate of 152 g C m
−2
yr
−1
. The total amount of restored wetlands within the restoration program studied here has a total area of 480 ha, and upscaling the carbon stocks to the whole area of restored ponds and wetlands gave a total carbon stock of 4.013 × 10
6
kg C in the top 6 cm of the sediments. If considering the potential increase of CO
2
and CH
4
from the ponds it is likely that the constructed ponds studied here are net carbon sources. We compared our results with published measurements of CO
2
and CH
4
emissions from small ponds in Sweden. This shows that the CO
2
equivalent emissions could be between 1.8 and 37.5 times higher than the sedimentary carbon accumulation. Our data indicate that small constructed ponds are potential net carbon sources. Therefore, we suggest that using small, constructed, or restored ponds as carbon mitigation strategy must be done with caution, and the potential for increased methane emissions must be considered.
Mesenchymal stem cells express epidermal markers in an in vitro reconstructed human skin model
Authors: Dos Santos Jeniffer Farias , Freitas-Marchi Bruna Letícia , Reigado Gustavo Roncoli , de Assis Silvia Romano , Maria Engler Silvya Stuchi , Chambergo Alcalde Felipe Santiago , Nunes Viviane Abreu 
Published: January 2023

Introduction: In skin traumas, such as burns, epidermal homeostasis is affected, often requiring clinical approaches. Different therapeutic strategies can be used including transplantation, besides the use of synthetic or natural materials with allogeneic cells. In this context, tissue engineering is an essential tool for skin regeneration, and using mesenchymal stem cells (MSC) from the umbilical cord appears to be a promising strategy in regenerative medicine due to its renewal and differentiation potential and hypo immunogenicity. We evaluated the transdifferentiation of MSC from umbilical cord into keratinocytes in three-dimensional (3D) in vitro skin models, using dermal equivalents composed by type I collagen with dermal fibroblasts and a commercial porcine skin decellularized matrix, both cultured at air-liquid interface (ALI).Methods: The expression of epidermal proteins cytokeratins (CK) 5, 14 and 10, involucrin and filaggrin was investigated by real-time PCR and immunofluorescence, in addition to the activity of epidermal kallikreins (KLK) on the hydrolysis of fluorogenic substrates.Results and discussion: The cultivation of MSCs with differentiation medium on these dermal supports resulted in organotypic cultures characterized by the expression of the epidermal markers CK5, CK14, CK10 and involucrin, mainly on the 7th day of culture, and filaggrin at 10th day in ALI. Also, there was a 3-fold increase in the KLK activity in the epidermal equivalents composed by MSC induced to differentiate into keratinocytes compared to the control (MSC cultivated in the proliferation medium). Specifically, the use of collagen and fibroblasts resulted in a more organized MSC-based organotypic culture in comparison to the decellularized matrix. Despite the non-typical epithelium structure formed by MSC onto dermal equivalents, the expression of important epidermal markers in addition to the paracrine effects of these cells in skin may indicate its potential use to produce skin-based substitutes.
Use of fluorescence imaging to optimize location of tissue sampling in hard-to-heal wounds
Authors: Serena Thomas E. , Snyder Robert J. , Bowler Philip G. 
Published: January 2023

IntroductionWound microflora in hard-to-heal wounds is invariably complex and diverse. Determining the interfering organisms(s) is therefore challenging. Tissue sampling, particularly in large wounds, is subjective and, when performed, might involve swabbing or biopsy of several locations. Fluorescence (FL) imaging of bacterial loads is a rapid, non-invasive method to objectively locate microbial hotspots (loads &gt;104 CFU/gr). When sampling is deemed clinically necessary, imaging may indicate an optimal site for tissue biopsy. This study aimed to investigate the microbiology of wound tissue incisional biopsies taken from sites identified by FL imaging compared with sites selected by clinical judgment.MethodsA post hoc analysis of the 350-patient FLAAG wound trial was conducted; 78 wounds were included in the present study. All 78 wounds were biopsied at two sites: one at the center of the wound per standard of care (SoC) and one site guided by FL-imaging findings, allowing for comparison of total bacterial load (TBL) and species present.ResultsThe comparison between the two biopsy sites revealed that clinical uncertainty was higher as wound surface area increased. The sensitivity of a FL-informed biopsy was 98.7% for accurately finding any bacterial loads &gt;104 CFU/g, compared to 87.2% for SoC (p=0.0059; McNemar test). Regarding species detected, FL-informed biopsies detected an average of 3 bacterial species per biopsy versus 2.2 species with SoC (p &lt; 0.001; t-test). Microbial hotspots with a higher number of pathogens also included the CDC’s pathogens of interest.Conclusions &amp; perspectiveFL imaging provides a more accurate and relevant microbiological profile that guides optimal wound sampling compared to clinical judgment. This is particularly interesting in large, complex wounds, as evidenced in the wounds studied in this post hoc analysis. In addition, fluorescence imaging enables earlier bacterial detection and intervention, guiding early and appropriate wound hygiene and potentially reducing the need for antibiotic use. When indicated, this diagnostic partnership with antibiotic stewardship initiatives is key to ameliorating the continuing threat of antibiotic resistance.
Case report: A rare manifestation of vasospasm induced myocardial infarction with ST-segment elevation in a young male patient
Authors: Diečkus Laurynas , Rodevič Greta , Baranauskas Arvydas , Davidavičius Giedrius , Budrys Povilas 
Published: January 2023

BackgroundMinority of acute myocardial infarctions (MI) are caused by a non-atherosclerotic occlusion of the coronary artery. We present a case report, where MI with ST-segment elevation was provoked by a vasospasm, which is a rare aetiological finding.Case presentation27-year-old male patient presented to the emergency department because of a sudden onset chest pain radiating to the left arm. The patient underwent percutaneous coronary intervention (PCI) to the right coronary artery (RCA) 3 months ago due to inferior wall MI, however, chest pain episodes kept on recurring at night throughout the whole period after the intervention. During current admission, initial electrocardiogram (ECG) demonstrated ST-segment elevation in leads II, III and aVF. Coronary angiogram revealed diffuse severe narrowing of the right coronary artery, which was relieved with intracoronary administration of nitrates and verapamil. After coronary angiogram patient was given oral long-acting nitrates and verapamil, however, during the following days nocturnal chest pain episodes reoccurred. It was decided to swap verapamil to diltiazem, which led to complete cessation of angina episodes. The patient was discharged in stable condition and symptom free. It was suspected that the first MI was of vasospastic origin, which likely led to unnecessary stenting.ConclusionsThis clinical case has demonstrated the challenges clinician could face in order to correctly diagnose vasospasm-induced MI because of its rare occurrence and highly variable presentation. We strongly suggest using intracoronary nitroglycerine during coronary angiography as a standard practice to avoid a potential diagnostic error and unnecessary stenting. Although, in some cases the reason behind coronary artery spasm (CAS) remains unclear, medical treatment can be very effective for CAS prevention.
Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy
Authors: Dolmaci Onur B. , Ayyildiz Tugay , Poelmann Robert E. , Driessen Antoine H. G. , Koolbergen Dave R. , Klautz Robert J. M. , Lindeman Jan H. N. , Grewal Nimrat 
Published: January 2023

ObjectivePatients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic complications. Bicuspidy is known to have a low risk for acquired coronary artery sclerosis. The aim of this study is to determine the risk of coronary sclerosis in MFS patients.MethodsMarfan syndrome patients with an aortic root dilatation, which were surgically treated between 1999 and 2017, were included and matched with BAV and tricuspid aortic valves (TAV) patients based on sex and age. Cardiovascular risk profiles were determined in all three groups. Coronary sclerosis was graded in all patients on coronary imaging (coronary angiography or computed tomography) using a coronary artery scoring method, which divides the coronaries in 28 segments and scores non-obstructive (20–49% sclerosis) and obstructive coronary sclerosis (&gt;49% sclerosis) in each segment.ResultsA total of 90 matched patients (30 within each group) were included. MFS patients showed less cardiovascular risk factors compared to BAV and TAV patients. TAV patients had higher amounts of obstructive coronary sclerosis as compared to BAV patients (p = 0.039) and MFS patients (p = 0.032). No difference in non- and obstructive coronary artery disease (CAD) was found between the MFS and BAV population.ConclusionMarfan syndrome and bicuspid aortic valve patients have a significantly lower risk for, and prevalence of CAD as compared to TAV individuals.
Case report: Left ventricular perforation caused by right ventricular pacemaker lead
Authors: Huang Xiang , Zhou Heng , Li Xiao-Mei , Li Xiao-Lan 
Published: January 2023

BackgroundPerforation of the interventricular septum and left ventricular (LV) free wall by a right ventricular (RV) lead is an extremely rare and potentially life-threatening complication. In this case report, we discussed the diagnosis and management of a very unusual complication of pacemaker (PM) implantation, i.e., LV perforation brought on by an RV pacing lead.Case summaryA 92-year-old man was admitted to Xiangyang No.1 People’s Hospital due to a complete atrioventricular block. We performed a dual-chamber PM implantation; however, on the second postoperative day (POD), pacemaker failure occurred. Thoracic computed tomography (CT) scan showed that RV lead had pierced the interventricular septum and LV free wall. A transvenous lead extraction of the penetrating lead was performed uneventfully, and RV lead was refixed at the lower RV septum on the 5th POD.DiscussionIdentification of high-risk patients is mandatory to prevent this serious complication, and transvenous lead extraction with cardiac surgery backup may be an option.
Predictive effect of different blood lipid parameters combined with carotid intima-media thickness on coronary artery disease
Authors: Yu Bingyan , Wu Ying , Li Wei , Zhou Langping , Lin Yan , Wang Weimian , Li Guang , Zhou Yingling , Hu Xiangming , Li Xiaohong 
Published: January 2023

BackgroundBlood lipids disorder and atherosclerosis are closely related to coronary artery disease (CAD). This study aims to compare different blood lipid parameters combined with carotid intima-media thickness (cIMT) in predicting CAD.MethodsThis was a retrospective study including patients who underwent coronary angiography for highly suspected CAD. Blood samples were taken for lipid profile analysis and cIMT was evaluated by carotid ultrasound. Logistic analysis was used to establish different models of different lipid parameters in predicting CAD. The area under the receiver operating characteristic curve (AUC) was used to examine the predictive value. The optimal lipid parameter was also used to explore the relationship with multi-vessel CAD.ResultsPatients were classified into two groups based on whether CAD existed. Compared with non-CAD patients, the CAD group had higher lipoprotein (a) [Lp (a)], apolipoprotein B/apolipoprotein A, total cholesterol/high-density lipoprotein cholesterol (HDL-C), triglyceride/HDL-C and LDL-C/HDL-C. According to the AUCs, Lp (a) combined with cIMT (AUC: 0.713, P &lt; 0.001) had the best performance in predicting CAD compared to other lipid parameters. High level of Lp (a) was also associated with multi-vessel CAD (odds ratio: 1.41, 95% confidence interval: 1.02–1.95, P = 0.036).ConclusionFor patients with highly suspected CAD, Lp (a) better improved the predictive value of CAD rather than most of blood lipid indices, especially in the absence of high levels of LDL-C. Lp (a) also can be used to predict the multi-vessel CAD.
Hydrodynamic variations and human activities have influenced sediment fluxes in the pearl river delta since the late holocene
Authors: Yang Xiaoqiang , Wu Shuang , Shang Shentang , Chen Yan 
Published: January 2023

Climate change and human activity can both exert a role in the river discharge and sediment load in river deltas when the sea level remains relatively stable. The Pearl River Delta constitutes the metropolitan region of the Guangdong–Hong Kong–Macau Greater Bay Area, and its evolution in the past and future impacts the sustainable development of this region. In this manuscript, a core situated in the northern South China Sea, adjacent to Qiao Island of Zhuhai city in the Pearl River Delta, was selected to investigate the hydrodynamic variation influenced by tropical processes and the sediment flux imposed by human activities. Using paleosecular variations (PSVs) in geomagnetic field correlations constrained by seven radiocarbon ages, an ∼2.5 kyr chronology was provided for core sediments ∼2.8 m in length. The magnetic fabric results suggest that deposition was influenced by the two types of hydrodynamic-weak energy modulated by El Niño–Southern Oscillation (ENSO) activity and higher energy regulated by high-frequency tropical storms. The cyclic variations in the degree of anisotropy of magnetic susceptibility (P) indicate two periodic changes at approximately 300 and 100 years, which were forced by ENSO activity, while the ratio of lineation with foliation (q value) implies a higher energy flow period of 1.3–1.9 kyr, arising from strong tropical storms. Moreover, the high saturation remanence (SIRM) introduces more sediment flux, which is impacted by growing human activity during the period of 1.0–1.6 kyr.