bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mathematical representation of the reactive scope model
Authors: Wright Justin , Buch Kelly , Beattie Ursula K. , Gormally Brenna M. G. , Romero L. Michael , Fefferman Nina 
Published: August 2023

AbstractResearchers have long sought to understand and predict an animal’s response to stressful stimuli. Since the introduction of the concept of homeostasis, a variety of model frameworks have been proposed to describe what is necessary for an animal to remain within this stable physiological state and the ramifications of leaving it. Romero et al. (Horm Behav 55(3):375–389, 2009) introduced the reactive scope model to provide a novel conceptual framework for the stress response that assumes an animal’s ability to tolerate a stressful stimulus may degrade over time in response to the stimulus. We provide a mathematical formulation for the reactive scope model using a system of ordinary differential equations and show that this model is capable of recreating existing experimental data. We also provide an experimental method that may be used to verify the model as well as several potential additions to the model. If future experimentation provides the necessary data to estimate the model’s parameters, the model presented here may be used to make quantitative predictions about physiological mediator levels during a stress response and predict the onset of homeostatic overload.
The collateral map: prediction of lesion growth and penumbra after acute anterior circulation ischemic stroke
Authors: Yi Jin Seok , Ki Hee Jong , Jeon Yoo Sung , Park Jeong Jin , Lee Taek-Jun , Kwak Jin Tae , Lee Sang Bong , Lee Hyung Jin , Kim In Seong , Kim Joo Hyun , Lee Ji Sung , Roh Hong Gee , Kim Hyun Jeong 
Published: August 2023

Abstract
Objectives
This study evaluated the collateral map’s ability to predict lesion growth and penumbra after acute anterior circulation ischemic strokes.

Methods
This was a retrospective analysis of selected data from a prospectively collected database. The lesion growth ratio was the ratio of the follow-up lesion volume to the baseline lesion volume on diffusion-weighted imaging (DWI). The time-to-maximum (Tmax)/DWI ratio was the ratio of the baseline Tmax  > 6 s volume to the baseline lesion volume. The collateral ratio was the ratio of the hypoperfused lesion volume of the phase_FU (phase with the hypoperfused lesions most approximate to the follow-up DWI lesion) to the hypoperfused lesion volume of the phase_baseline of the collateral map. Multiple logistic regression analyses were conducted to identify independent predictors of lesion growth. The concordance correlation coefficients of Tmax/DWI ratio and collateral ratio for lesion growth ratio were analyzed.

Results
Fifty-two patients, including twenty-six males (mean age, 74 years), were included. Intermediate (OR, 1234.5; p < 0.001) and poor collateral perfusion grades (OR, 664.7; p = 0.006) were independently associated with lesion growth. Phase_FUs were immediately preceded phases of the phase_baselines in intermediate or poor collateral perfusion grades. The concordance correlation coefficients of the Tmax/DWI ratio and collateral ratio for the lesion growth ratio were 0.28 (95% CI, 0.17–0.38) and 0.88 (95% CI, 0.82–0.92), respectively.

Conclusion
Precise prediction of lesion growth and penumbra can be possible using collateral maps, allowing for personalized application of recanalization treatments. Further studies are needed to generalize the findings of this study.

Clinical relevance statement
Precise prediction of lesion growth and penumbra can be possible using collateral maps, allowing for personalized application of recanalization treatments.

Key Points
• Cell viability in cerebral ischemia due to proximal arterial steno-occlusion mainly depends on the collateral circulation.
• The collateral map shows salvageable brain extent, which can survive by recanalization treatments after acute anterior circulation ischemic stroke.
• Precise estimation of salvageable brain makes it possible to make patient-specific treatment decision.
Global Change in Agricultural Flash Drought over the 21st Century
Authors: Black Emily 
Published: August 2023

AbstractAgricultural flash droughts are high-impact phenomena, characterized by rapid soil moisture dry down. The ensuing dry conditions can persist for weeks to months, with detrimental effects on natural ecosystems and crop cultivation. Increases in the frequency of these rare events in a future warmer climate would have significant societal impact. This study uses an ensemble of 10 Coupled Model Intercomparison Project (CMIP) models to investigate the projected change in agricultural flash drought during the 21st century. Comparison across geographical regions and climatic zones indicates that individual events are preceded by anomalously low relative humidity and precipitation, with long-term trends governed by changes in temperature, relative humidity, and soil moisture. As a result of these processes, the frequency of both upper-level and root-zone flash drought is projected to more than double in the mid- and high latitudes over the 21st century, with hot spots developing in the temperate regions of Europe, and humid regions of South America, Europe, and southern Africa.
Delegation ärztlicher Leistungen an rheumatologische Fachassistenten
Authors: Hoeper Juliana Rachel , Schuch Florian , Steffens-Korbanka Patricia , Gauler Georg , Welcker Martin , Wendler Jörg , von Hinüber Ulrich , Meyer Sara Eileen , Schwarting Andreas , Zeidler Jan , Witte Torsten , Meyer-Olson Dirk , Hoeper Kirsten 
Published: August 2023

Zusammenfassung
Hintergrund
Bei 80 % der Patienten mit einer rheumatoiden Arthritis (RA) tritt mindestens eine Komorbidität auf. Neben kardiovaskulären Komorbiditäten sind psychische Erkrankungen häufig. Die Prävalenz von Depression und Angst ist bei Betroffenen höher als in der Allgemeinbevölkerung. Ein Screening auf Komorbidität ist hoch relevant. Die Unterversorgung im fachärztlichen Bereich lässt dies kaum zu. Die Implementierung einer Visite durch die rheumatologische Fachassistenz (RFA) bietet Potenzial, die Versorgung zu verbessern und der Unterversorgung zu begegnen.

Fragestellung
Ziel ist, Auswirkungen einer teambasierten Versorgung auf den Verlauf von Depression und Angst bei Patienten mit einer seropositiven RA im Krankheitsschub zu untersuchen.

Material und Methoden
Es handelt sich um eine multizentrische, pragmatische, randomisierte, kontrollierte Studie über 1 Jahr mit 224 Patienten. Nach Baseline folgen 5 Visiten. In der Interventionsgruppe (IG) fanden 3 zunächst bei der RFA statt. Depression, Angst und Behandlungszufriedenheit werden genauer betrachtet.

Ergebnisse
In der IG hat sich die ängstliche Symptomatik über 12 Monate signifikant verbessert (p = 0,036). Auch die Anteile der Patienten mit Ängstlichkeit verändern sich signifikant in der Interventionsgruppe (p < 0,001), während es in der Kontrollgruppe im Vergleich zwischen Baseline und Monat 12 zu keiner Veränderung kam. Die Werte der Depressionsskala unterschieden sich nicht signifikant (p = 0,866). Bei der Dimension „Information“ des Zufriedenheitsfragebogens haben sich die Patienten in der IG nach 6 (p = 0,013) und 12 Monaten (p = 0,003) signifikant besser informiert gefühlt.

Diskussion
Ein positiver Effekt der teambasierten Versorgung auf den Verlauf von Depression und Angst bei Patienten mit einer seropositiven RA im Krankheitsschub konnte gezeigt werden.
Digital live imaging of intraoperative electrocochleography during cochlear implantation: the first 50 patients
Authors: Höing Benedikt , Eichler Theda , Juelly Viktoria , Meyer Moritz , Jung Lea , Waschkies Laura , Lang Stephan , Arweiler-Harbeck Diana 
Published: August 2023

Abstract
Introduction
Real-time visualization of intraoperative electrocochleography (ECochG) potentials via a digital microscope during cochlear implantation can provide direct feedback during electrode insertion. The aim of this prospective, randomized study of 50 patients was to obtain long-term data with a focus on residual hearing preservation and speech understanding.

Material and methods
Cochlear implantations were performed in 50 patients (26 female, 24 male) with residual hearing using a digital microscope. Patients were randomized into two groups. Intraoperative ECochG potentials were either displayed directly in the surgeon’s field of view (picture-in-picture display, PiP) or not directly in the field of view (without picture-in-picture display, without PiP). Residual hearing preservation and speech comprehension were recorded within a 1-year follow-up period, compared between groups (PiP versus without PiP) and to a control group of 26 patients implanted without ECochG.

Results
Mean insertion time was significantly longer in the picture-in-picture group (p = 0.025). Residual hearing preservation after 6 weeks at 250 Hz was significantly better in the picture-in-picture group (p = 0.017). After one year, 76% of patients showed residual hearing in the picture-in-picture group (62% without picture-in-picture technique, p = n.s.). Use of the picture-in-picture technique resulted in better long-term pure tone residual hearing preservation at 250, 500, and 1000 Hz. Speech intelligibility improved by 46% in the picture-in-picture group (38% without picture-in-picture).

Discussion
This study is the first to describe long-term results in a large cohort of cochlear implant patients in whom digital visualization of intraoperative ECochG was used. Our results show that visualization of intraoperative ECochG has a positive effect on residual hearing preservation.
Quantification of arbuscular mycorrhizal fungi root colonization in wheat, tomato, and leek using absolute qPCR
Authors: Corona Ramírez Andrea , Symanczik Sarah , Gallusser Tabea , Bodenhausen Natacha 
Published: August 2023

AbstractArbuscular mycorrhizal fungi (AMF) form symbioses with most terrestrial plants and are known to have a positive effect on plant growth and health. Different methodologies have been developed to assess the AMF-plant symbiosis. The most applied method, which involves staining of roots and microscopic observation of the AMF structures, is tedious and time-consuming and the results are highly dependent on the observer. Using quantitative polymerase chain reaction (qPCR) to quantify AMF root colonization represents a reliable, high-throughput technique that allows the assessment of numerous samples. Quantification with qPCR can be performed through two methods: relative quantification and absolute quantification. In relative quantification, the target gene is normalized with a reference gene. On the other hand, absolute quantification involves the use of a standard curve, for which template DNA is serially diluted. In a previous paper, we validated the primer pair AMG1F and AM1 for a relative quantification approach to assess AMF root colonization in Petunia. Here, we tested the same primers with an absolute quantification approach and compared the results with the traditional microscopy method. We evaluated the qPCR method with three different crops, namely, wheat (cv. Colmetta and Wiwa), tomato, and leek. We observed a strong correlation between microscopy and qPCR for Colmetta (r = 0.90, p < 0.001), Wiwa (r = 0.94, p < 0.001), and tomato (r = 0.93, p < 0.001), but no correlation for leek (r = 0.27, p = 0.268). This highlights the importance of testing the primer pair for each specific crop.
Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence
Authors: Baach Florence , Meyer Boglarka , Oh Jun , Lezius Susanne , Böger Rainer , Schwedhelm Edzard , Choe Chi-un , Neu Axel 
Published: August 2023

AbstractGuanidino compounds such as dimethylarginines (SDMA, ADMA) and L-homoarginine ((L-)hArg) can interfere with bioavailability and function of the main NO-donor L-arginine (L-Arg). High ADMA and SDMA but low L-hArg concentrations have been associated with cardio- and cerebrovascular events and mortality in adults. The role of guanidino compounds in paediatric patients remains less clear. We, therefore, compared guanidino compound levels in plasma samples of 57 individuals with chronic kidney disease (CKD) and 141 individuals without CKD from the age of 0 to 17 years, including patients with different comorbidities by correlation and regression analyses. We found highest hArg, SDMA and ADMA concentrations in neonates (Kruskal–Wallis, p < 0.001 for all). From the age of 1 year on, hArg levels increased, whereas SDMA und ADMA levels further decreased in children. SDMA and ADMA are higher in children with CKD independent of GFR (mean factor 1.92 and 1.38, respectively, p < 0.001 for both), and SDMA is strongly correlated with creatinine concentration in children with CKD (Spearman’s rho 0.74, p < 0.001). We provide guanidino compound levels in a large sample covering all paediatric age groups for the first time. Our data can be used to assess the role of guanidino compounds such as hArg in disease states, i.e. cerebro- and cardiovascular disorders in childhood and adolescence.
Critical State Characterization of New Zealand East Coast Sand for Numerical Modeling
Authors: Bolarinwa Ademola , Kalatehjari Roohollah , Rashid Ahmad Safuan A. 
Published: August 2023

AbstractThis paper outlines the findings of a laboratory-based and numerical study to investigate the undrained flow failure behavior of East Coast Sand (ECS). ECS is a commonly encountered coastal deposit from the upper North Island of New Zealand. The study focused on establishing the undrained strength characteristics of ECS under static, triaxial compressive loading conditions, and at confining pressures in the range of typical engineering interest and for a range of soil densities considered in loosely deposited sands. The research objectives of establishing the basic soil properties and the intrinsic advanced geomechanical properties specific to ECS from Auckland were achieved through laboratory experiments and matching numerical simulations with an advanced critical-state compatible soil constitutive model (Norsand). The current work examined five different aspects of the ECS undrained behavior under static loads. It was shown that loosely deposited ECS within mean effective stresses ranging between 50 and 200 kPa was highly susceptible to expensive flow failures of structures built on or with them. The obtained approximate peak undrained shear strengths before failure and critical states were 29 kPa, 84 kPa, 130 kPa, and 200 kPa for test confining stresses of 50 kPa, 100 kPa, 200 kPa, and 300 kPa, respectively. Similarly, the corresponding excess pore water pressures were 48 kPa, 98 kPa, 200 kPa, and 240 kPa, respectively. The above results proved that the soil’s effective and confining stress are key determinants of the soil’s undrained shear strength characteristics which was consistent with the existing literature.
Conservation genetics of the steno-endemic Chorthippus lacustris (Orthoptera: Acrididae)
Authors: Toli Elisavet-Aspasia , Zacharopoulou Panoraia , Bounas Anastasios , Kati Vassiliki , Sotiropoulos Konstantinos 
Published: August 2023

AbstractInvertebrate populations are amongst the most widespread species, inhabiting a variety of habitats, however there is limited conservation effort due to the scarce knowledge on their population genetics. Here, we assess levels of genetic diversity and population structure of the Epirus dancing grasshopper (Chorthippus lacustris), a steno-endemic species, located in Northwest Greece, exhibiting a fragmented distribution. By utilizing two mitochondrial genes and amplified fragment length polymorphisms (AFLPs), we detected moderate to high levels of genetic diversity of the focal populations. Haplotype network analysis revealed the existence of private haplotypes with low genetic differentiation suggesting a sudden expansion of the species in the study area with subsequent isolations on suitable habitats. Despite the low genetic differentiation between the studied populations, our data further suggest a subtle subdivision of the populations and the existence of three genetic clusters. Implications for insect conservation: Our study is the first to provide insights into the population genetics of the steno-endemic grasshopper C. lacustris, highlighting the importance of preserving focal populations. The species inhabits areas subject to high changes in land use and fragmentation. We argue that the preservation and management of suitable habitats is essential for the viability of the grasshopper populations.
Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats
Authors: Ahmed-Farid O. A. , Abdelrazek Areeg M. , Elwakel Hend , Mohamed Maha M. 
Published: August 2023

AbstractHigh salt intake increases inflammatory and oxidative stress responses and causes an imbalance of neurotransmitters involved in the pathogenesis of hypertension that is related to the onset of cerebral injury. Using natural compounds that target oxidative stress and neuroinflammation pathways remains a promising approach for treating neurological diseases. Barley (Hordeum vulgare L.) seeds are rich in protein, fiber, minerals, and phenolic compounds, that exhibit potent neuroprotective effects in various neurodegenerative diseases. Therefore, this work aimed to investigate the efficacy of barley ethanolic extract against a high salt diet (HSD)-induced cerebellum injury in hypertensive rats. Forty-eight Wistar rats were divided into six groups. Group (I) was the control. The second group, the HSD group, was fed a diet containing 8% NaCl. Groups II and III were fed an HSD and simultaneously treated with either amlodipine (1 mg /kg b.wt p.o) or barley extract (1000 mg /kg b.wt p.o) for five weeks. Groups IV and V were fed HSD for five weeks, then administered with either amlodipine or barley extract for another five weeks. The results revealed that barley treatment significantly reduced blood pressure and effectively reduced oxidative stress and inflammation in rat's cerebellum as indicated by higher GSH and nitric oxide levels and lower malondialdehyde, TNF-α, and IL-1ß levels. Additionally, barley restored the balance of neurotransmitters and improved cellular energy performance in the cerebellum of HSD-fed rats. These findings suggest that barley supplementation exerted protective effects against high salt-induced hypertension by an antioxidant, anti-inflammatory, and vasodilating effects and restoring neurochemical alterations.
Graphical abstract
A rule-based obfuscating focused crawler in the audio retrieval domain
Authors: Montanaro Marco , Rinaldi Antonio Maria , Russo Cristiano , Tommasino Cristian 
Published: August 2023

AbstractThe detection of violations of intellectual properties on multimedia files is a critical problem for the current infrastructure of the Internet, especially within very large document collections. To contrast such a problem, either proactive or reactive methods are used. The first category prevents the upload of infringing files themselves by comparing illegal files with a reference collection, while the second one responds to reports made by third parties or artificial intelligence systems in order to delete files deemed illegal. In this article we propose an approach that is both reactive and proactive at the same time, with the aim of preventing the deletion of legal uploads of files (or modifications of such files, such as remixes, parodies and other edits) due to the presence of illegal uploads on a platform. We developed a rule-based obfuscating focused crawler able to work with audio files in the Audio Information Retrieval (AIR) domain, but its use can be easily extended to other multimedia file types, such as videos or textual documents. Our proposed model automatically scans multimedia files uploaded to the public collection only when a user query is submitted to it. We will also show experimental results obtained during tests on a known musical collection. Several combinations of specific Neural Network-Similarity Scorer solutions are shown, and we will discuss the strength and efficiency of each combination.
Pharmaceutical Care Network Europe definition of quality indicators for pharmaceutical care: a systematic literature review and international consensus development
Authors: Fujita Kenji , Halvorsen Kjell H. , Sato Noriko , Jazbar Janja , Modamio Pilar , Waltering Isabel , De Wulf Isabelle , Westerlund Tommy , Chen Timothy F. , Teichert Martina 
Published: August 2023

Abstract
Background
Over the past 40 years, the tasks of pharmacists have shifted from logistic services to pharmaceutical care (PhC). Despite the increasing importance of measuring quality of care, there is no general definition of Quality Indicators (QIs) to measure PhC. Recognising this, a working group in a European association of PhC researchers, the Pharmaceutical Care Network Europe (PCNE), was established in 2020.

Aim
This research aimed to review existing definitions of QIs and develop a definition of QIs for PhC.

Method
A two-step procedure was applied. Firstly, a systematic literature review was conducted to identify existing QI definitions that were summarised. Secondly, an expert panel, comprised of 17 international experts from 14 countries, participated in two surveys and a discussion using a modified Delphi technique to develop the definition of QIs for PhC.

Results
A total of 182 QI definitions were identified from 174 articles. Of these, 63 QI definitions (35%) cited one of five references as the source. Sixteen aspects that construct QI definitions were derived from the identified definitions. As a result of the Delphi study, the panel reached an agreement on a one-sentence definition of QIs for PhC: “quality indicators for pharmaceutical care are validated measurement tools to monitor structures, processes or outcomes in the context of care provided by pharmacists”.

Conclusion
Building upon existing definition of QIs, an international expert panel developed the PCNE definition of QIs for PhC. This definition is intended for universal use amongst researchers and healthcare providers in PhC.
Write, talk and rewrite: the effectiveness of a dialogic writing intervention in upper elementary education
Authors: Bouwer Renske , van der Veen Chiel 
Published: August 2023

AbstractIn this research, we developed and empirically tested a dialogic writing intervention, an integrated language approach in which grade 5/6 students learn how to write, talk about their writing with peers, and rewrite. The effectiveness of this intervention was experimentally tested in ten classes from eight schools, using a pretest–posttest control group design. Classes were randomly assigned to the intervention group (5 classes; 95 students) or control group (5 classes; 115 students). Both groups followed the same eight lessons in which students wrote four argumentative texts about sustainability. For each text, students wrote a draft version, which they discussed in groups of three students. Based on these peer conversations, students revised their text. The intervention group received additional support to foster dialogic peer conversations, including a conversation chart for students and a practice-based professional development program for teachers. Improvements in writing were measured by an argumentative writing task (same genre, but different topic; near transfer) and an instructional writing task (different genre and topic; far transfer). Text quality was holistically assessed using a benchmark rating procedure. Results show that our dialogic writing intervention with support for dialogic talk significantly improved students’ argumentative writing skills (ES = 1.09), but that the effects were not automatically transferable to another genre. Based on these results we conclude that a dialogic writing intervention is a promising approach to teach students how to talk about their texts and to write texts that are more persuasive to readers.