bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airborne Absolute Gravimetry With a Quantum Sensor, Comparison With Classical Technologies
Authors: Bidel Y. , Zahzam N. , Bresson A. , Blanchard C. , Bonnin A. , Bernard J. , Cadoret M. , Jensen T. E. , Forsberg R. , Salaun C. , Lucas S. , Lequentrec‐Lalancette M. F. , Rouxel D. , Gabalda G. , Seoane L. , Vu D. T. , Bruinsma S. , Bonvalot S. 
Published: March 2023

AbstractWe report an airborne gravity survey with an absolute gravimeter based on atom interferometry and two relative gravimeters: a classical LaCoste&Romberg (L&R) and a novel iMAR strapdown Inertial Measurement Unit. We estimated measurement errors for the quantum gravimeter ranging from 0.6 to 1.3 mGal depending on the flight conditions and the filtering used. Similar measurement errors are obtained with iMAR strapdown gravimeter, but the long‐term stability is five times worse. The traditional L&R platform gravimeter shows larger measurement errors (3–4 mGal). Airborne measurements have been compared to marine, land, and altimetry‐derived gravity data. We obtain a good agreement for the quantum gravimeter with standard deviations and means on differences below or equal to 2 mGal. This study confirms the potential of quantum technology for absolute airborne gravimetry, which is particularly interesting for mapping shallow water or mountainous areas and for linking ground and satellite measurements with homogeneous absolute referencing.
A Scheme for Representing Aromatic Secondary Organic Aerosols in Chemical Transport Models: Application to Source Attribution of Organic Aerosols Over South Korea During the KORUS‐AQ Campaign
Authors: Brewer J. F. , Jacob D. J. , Jathar S. H. , He Y. , Akherati A. , Zhai S. , Jo D. S. , Hodzic A. , Nault B. A. , Campuzano‐Jost P. , Jimenez J. L. , Park R. J. , Oak Y. J. , Liao H. 
Published: March 2023

AbstractWe present a new volatility basis set (VBS) representation of aromatic secondary organic aerosol (SOA) for atmospheric chemistry models by fitting a statistical oxidation model with aerosol microphysics (SOM‐TOMAS) to results from laboratory chamber experiments. The resulting SOM‐VBS scheme also including previous work on SOA formation from semi‐ and intermediate volatile organic compounds (S/IVOCs) is implemented in the GEOS‐Chem chemical transport model and applied to simulation of observations from the Korea‐United States Air Quality Study (KORUS‐AQ) field campaign over South Korea in May–June 2016. Our SOM‐VBS scheme can simulate the KORUS‐AQ organic aerosol (OA) observations from aircraft and surface sites better than the default schemes used in GEOS‐Chem including for vertical profiles, diurnal cycle, and partitioning between hydrocarbon‐like OA and oxidized OA. Our results confirm the important contributions of oxidized primary OA and aromatic SOA found in previous analyses of the KORUS‐AQ data and further show a large contribution from S/IVOCs. Model source attribution of OA in surface air over South Korea indicates one third from domestic anthropogenic emissions, with a large contribution from toluene and xylenes, one third from external anthropogenic emissions, and one third from natural emissions.
Correlative light-electron microscopy using small gold nanoparticles as single probes
Authors: Pope Iestyn , Tanner Hugh , Masia Francesco , Payne Lukas , Arkill Kenton Paul , Mantell Judith , Langbein Wolfgang , Borri Paola , Verkade Paul 
Published: March 2023

AbstractCorrelative light-electron microscopy (CLEM) requires the availability of robust probes which are visible both in light and electron microscopy. Here we demonstrate a CLEM approach using small gold nanoparticles as a single probe. Individual gold nanoparticles bound to the epidermal growth factor protein were located with nanometric precision background-free in human cancer cells by light microscopy using resonant four-wave mixing (FWM), and were correlatively mapped with high accuracy to the corresponding transmission electron microscopy images. We used nanoparticles of 10 nm and 5 nm radius, and show a correlation accuracy below 60 nm over an area larger than 10 µm size, without the need for additional fiducial markers. Correlation accuracy was improved to below 40 nm by reducing systematic errors, while the localisation precision is below 10 nm. Polarisation-resolved FWM correlates with nanoparticle shapes, promising for multiplexing by shape recognition in future applications. Owing to the photostability of gold nanoparticles and the applicability of FWM microscopy to living cells, FWM-CLEM opens up a powerful alternative to fluorescence-based methods.
Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis
Authors: Niemsiri Vipavee , Rosenthal Sara Brin , Nievergelt Caroline M. , Maihofer Adam X. , Marchetto Maria C. , Santos Renata , Shekhtman Tatyana , Alliey-Rodriguez Ney , Anand Amit , Balaraman Yokesh , Berrettini Wade H. , Bertram Holli , Burdick Katherine E. , Calabrese Joseph R. , Calkin Cynthia V. , Conroy Carla , Coryell William H. , DeModena Anna , Eyler Lisa T. , Feeder Scott , Fisher Carrie , Frazier Nicole , Frye Mark A. , Gao Keming , Garnham Julie , Gershon Elliot S. , Goes Fernando S. , Goto Toyomi , Harrington Gloria J. , Jakobsen Petter , Kamali Masoud , Kelly Marisa , Leckband Susan G. , Lohoff Falk W. , McCarthy Michael J. , McInnis Melvin G. , Craig David , Millett Caitlin E. , Mondimore Francis , Morken Gunnar , Nurnberger John I. , Donovan Claire O’ , Øedegaard Ketil J. , Ryan Kelly , Schinagle Martha , Shilling Paul D. , Slaney Claire , Stapp Emma K. , Stautland Andrea , Tarwater Bruce , Zandi Peter P. , Alda Martin , Fisch Kathleen M. , Gage Fred H. , Kelsoe John R. 
Published: March 2023

AbstractLithium (Li) is one of the most effective drugs for treating bipolar disorder (BD), however, there is presently no way to predict response to guide treatment. The aim of this study is to identify functional genes and pathways that distinguish BD Li responders (LR) from BD Li non-responders (NR). An initial Pharmacogenomics of Bipolar Disorder study (PGBD) GWAS of lithium response did not provide any significant results. As a result, we then employed network-based integrative analysis of transcriptomic and genomic data. In transcriptomic study of iPSC-derived neurons, 41 significantly differentially expressed (DE) genes were identified in LR vs NR regardless of lithium exposure. In the PGBD, post-GWAS gene prioritization using the GWA-boosting (GWAB) approach identified 1119 candidate genes. Following DE-derived network propagation, there was a highly significant overlap of genes between the top 500- and top 2000-proximal gene networks and the GWAB gene list (Phypergeometric = 1.28E–09 and 4.10E–18, respectively). Functional enrichment analyses of the top 500 proximal network genes identified focal adhesion and the extracellular matrix (ECM) as the most significant functions. Our findings suggest that the difference between LR and NR was a much greater effect than that of lithium. The direct impact of dysregulation of focal adhesion on axon guidance and neuronal circuits could underpin mechanisms of response to lithium, as well as underlying BD. It also highlights the power of integrative multi-omics analysis of transcriptomic and genomic profiling to gain molecular insights into lithium response in BD.
Empirically driven transdiagnostic stages in the development of mood, anxiety and psychotic symptoms in a cohort of youth followed from birth
Authors: Ratheesh Aswin , Hammond Dylan , Gao Caroline , Marwaha Steven , Thompson Andrew , Hartmann Jessica , Davey Christopher , Zammit Stanley , Berk Michael , McGorry Patrick , Nelson Barnaby 
Published: March 2023

AbstractStaging models with transdiagnostic validity across mood, psychotic, and anxiety disorders could advance early intervention efforts as well as our understanding of the common underpinnings of such psychopathology. However, there are few well-supported operationalisations for such transdiagnostic models, particularly in community-based samples. We aimed to explore the inter-relationships among mood, psychotic, and anxiety symptom stages, and their common risk factors to develop data-informed transdiagnostic stages. We included participants from the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective ongoing birth cohort study. We developed operational thresholds for stages of depressive, hypomanic, anxiety, and psychotic symptoms based on the existing literature, refined further by expert consensus. We selected 1b level as the primary stage or outcome of interest. This represents moderate symptoms that are likely to be associated with the onset of the need for clinical mental health care. We used questionnaire and clinic data completed by young people ages 18 and 21 years. We used descriptive methods and network analyses to examine the overlap among Stage 1b psychopathology. We then examined the patterns of relationships between several risk factors and 1b stages using logistic regressions. Among 3269 young people with data available to determine all symptom stages, 64.3% were female and 96% Caucasian. Descriptive and network analyses indicated that 1b level depressive, anxiety, and psychotic symptom stages were inter-related while hypomania was not. Similarly, anxiety, depressive, and psychotic 1b stages were associated with the female sex, more emotional and behavioral difficulties in early adolescence, and life events in late adolescence. Hypomania was not related to any of these risk factors. Given their inter-relationships and similar risk factors, anxiety, psychotic and depressive, symptoms could be combined to form a transdiagnostic stage in this cohort. Such empirical transdiagnostic stages could help with prognostication and indicated prevention in youth mental health.
Multiple myeloma with acute light chain cast nephropathy
Authors: Leung Nelson , Rajkumar S. Vincent 
Published: March 2023

AbstractLight chain cast nephropathy (LCCN) is a leading cause of acute kidney injury (AKI) in patients with multiple myeloma (MM) and is now defined as a myeloma defining event. While the long-term prognosis has improved with novel agents, short-term mortality remains significantly higher in patients with LCCN especially if the renal failure is not reversed. Recovery of renal function requires a rapid and significant reduction of the involved serum free light chain. Therefore, proper treatment of these patients is of the utmost importance. In this paper, we provide an algorithm for treatment of MM patients who present with biopsy-proven LCCN or in those where other causes of AKI have been ruled out. The algorithm is based on data from randomized trial whenever possible. When trial data is not available, our recommendations is based on non-randomized data and expert opinions on best practices. We recommend that all patients should enroll in a clinical trial if available prior to resorting to the treatment algorithm we outlined.
RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy
Authors: Huang Zijing , Liang Jiajian , Chen Shaolang , Ng Tsz Kin , Brelén Marten E. , Liu Qingping , Yang Rucui , Xie Biyao , Ke Shuping , Chen Weiqi , Huang Dingguo 
Published: March 2023

AbstractDiabetic retinopathy (DR) is a leading cause of blindness that poses significant public health concerns worldwide. Increasing evidence suggests that neuroinflammation plays a key role in the early stages of DR. Microglia, long-lived immune cells in the central nervous system, can become activated in response to pathological insults and contribute to retinal neuroinflammation. However, the molecular mechanisms of microglial activation during the early stages of DR are not fully understood. In this study, we used in vivo and in vitro assays to investigate the role of microglial activation in the early pathogenesis of DR. We found that activated microglia triggered an inflammatory cascade through a process called necroptosis, a newly discovered pathway of regulated cell death. In the diabetic retina, key components of the necroptotic machinery, including RIP1, RIP3, and MLKL, were highly expressed and mainly localized in activated microglia. Knockdown of RIP3 in DR mice reduced microglial necroptosis and decreased pro-inflammatory cytokines. Additionally, blocking necroptosis with the specific inhibitor GSK-872 improved retinal neuroinflammation and neurodegeneration, as well as visual function in diabetic mice. RIP3-mediated necroptosis was activated and contributed to inflammation in BV2 microglia under hyperglycaemic conditions. Our data demonstrate the importance of microglial necroptosis in retinal neuroinflammation related to diabetes and suggest that targeting necroptosis in microglia may be a promising therapeutic strategy for the early stages of DR.
Targeting Aurora-A inhibits tumor progression and sensitizes thyroid carcinoma to Sorafenib by decreasing PFKFB3-mediated glycolysis
Authors: Jingtai Zhi , Linfei Hu , Yuyang Qian , Ning Kang , Xinwei Yun , Xin Wang , Xianhui Ruan , Dongmei Huang , Weiwei Yang , Xiangrui Meng , Tianze Zhu , Wei Wang , Xiangqian Zheng 
Published: March 2023

AbstractThyroid cancer (TC) is the most common endocrine tumor, amongst which anaplastic thyroid carcinoma (ATC) is the most deadly. Aurora-A usually functions as oncogenes, and its inhibitor Alisertib exerts a powerful antitumor effect in various tumors. However, the mechanism of Aurora-A in regulating TC cell energy supply remains unclear. In the present study, we demonstrated the antitumor effect of Alisertib and an association between high Aurora-A expression and shorter survival. Multi-omics data and in vitro validation data suggested that Aurora-A induced PFKFB3-mediated glycolysis to increase ATP supply, which significantly upregulated the phosphorylation of ERK and AKT. Furthermore, the combination of Alisertib and Sorafenib had a synergistic effect, further confirmed in xenograft models and in vitro. Collectively, our study provides compelling evidence of the prognostic value of Aurora-A expression and suggests that Aurora-A upregulates PFKFB3-mediated glycolysis to enhance ATP supply and promote TC progression. Combining Alisertib with Sorafenib has huge prospects for application in treating advanced thyroid carcinoma.
Genetic Creutzfeldt‒Jakob disease with 5-octapeptide repeats presented as frontotemporal dementia
Authors: Hamada Shinsuke , Takahashi-Iwata Ikuko , Satoh Katsuya , Kitamoto Tetsuyuki , Mizusawa Hidehiro , Moriwaka Fumio , Yabe Ichiro 
Published: March 2023

AbstractThe N-terminus of the PRNP gene normally contains a 5-octapeptide repeat (R1-R2-R2-R3-R4), and insertions at this locus can cause hereditary prion diseases. In the present study, we found a 5-octapeptide repeat insertion (5-OPRI) in a sibling case of frontotemporal dementia. Consistent with previous literature, 5-OPRI rarely met the diagnostic criteria for Creutzfeldt‒Jakob disease (CJD). We propose 5-OPRI as a suspected causative mutation for early-onset dementia, especially the frontotemporal type.
Muscle cell-type diversification is driven by bHLH transcription factor expansion and extensive effector gene duplications
Authors: Cole Alison G. , Jahnel Stefan M. , Kaul Sabrina , Steger Julia , Hagauer Julia , Denner Andreas , Murguia Patricio Ferrer , Taudes Elisabeth , Zimmermann Bob , Reischl Robert , Steinmetz Patrick R. H. , Technau Ulrich 
Published: March 2023

AbstractAnimals are typically composed of hundreds of different cell types, yet mechanisms underlying the emergence of new cell types remain unclear. Here we address the origin and diversification of muscle cells in the non-bilaterian, diploblastic sea anemone Nematostella vectensis. We discern two fast and two slow-contracting muscle cell populations, which differ by extensive sets of paralogous structural protein genes. We find that the regulatory gene set of the slow cnidarian muscles is remarkably similar to the bilaterian cardiac muscle, while the two fast muscles differ substantially from each other in terms of transcription factor profiles, though driving the same set of structural protein genes and having similar physiological characteristics. We show that anthozoan-specific paralogs of Paraxis/Twist/Hand-related bHLH transcription factors are involved in the formation of fast and slow muscles. Our data suggest that the subsequent recruitment of an entire effector gene set from the inner cell layer into the neural ectoderm contributes to the evolution of a novel muscle cell type. Thus, we conclude that extensive transcription factor gene duplications and co-option of effector modules act as an evolutionary mechanism underlying cell type diversification during metazoan evolution.
High-entropy alloy nanopatterns by prescribed metallization of DNA origami templates
Authors: Xie Mo , Fang Weina , Qu Zhibei , Hu Yang , Zhang Yichi , Chao Jie , Shi Jiye , Wang Lihua , Wang Lianhui , Tian Yang , Fan Chunhai , Liu Huajie 
Published: March 2023

AbstractHigh-entropy multimetallic nanopatterns with controlled morphology, composition and uniformity hold great potential for developing nanoelectronics, nanophotonics and catalysis. Nevertheless, the lack of general methods for patterning multiple metals poses a limit. Here, we develop a DNA origami-based metallization reaction system to prescribe multimetallic nanopatterns with peroxidase-like activities. We find that strong coordination between metal elements and DNA bases enables the accumulation of metal ions on protruding clustered DNA (pcDNA) that are prescribed on DNA origami. As a result of the condensation of pcDNA, these sites can serve as nucleation site for metal plating. We have synthesized multimetallic nanopatterns composed of up to five metal elements (Co, Pd, Pt, Ag and Ni), and obtained insights on elemental uniformity control at the nanoscale. This method provides an alternative pathway to construct a library of multimetallic nanopatterns.
An electron-hole rich dual-site nickel catalyst for efficient photocatalytic overall water splitting
Authors: Yan Xiaoqing , Xia Mengyang , Liu Hanxuan , Zhang Bin , Chang Chunran , Wang Lianzhou , Yang Guidong 
Published: March 2023

AbstractPhotocatalysis offers an attractive strategy to upgrade H2O to renewable fuel H2. However, current photocatalytic hydrogen production technology often relies on additional sacrificial agents and noble metal cocatalysts, and there are limited photocatalysts possessing overall water splitting performance on their own. Here, we successfully construct an efficient catalytic system to realize overall water splitting, where hole-rich nickel phosphides (Ni2P) with polymeric carbon-oxygen semiconductor (PCOS) is the site for oxygen generation and electron-rich Ni2P with nickel sulfide (NiS) serves as the other site for producing H2. The electron-hole rich Ni2P based photocatalyst exhibits fast kinetics and a low thermodynamic energy barrier for overall water splitting with stoichiometric 2:1 hydrogen to oxygen ratio (150.7 μmol h−1H2and 70.2 μmol h−1O2produced per 100 mg photocatalyst) in a neutral solution. Density functional theory calculations show that the co-loading in Ni2P and its hybridization with PCOS or NiS can effectively regulate the electronic structures of the surface active sites, alter the reaction pathway, reduce the reaction energy barrier, boost the overall water splitting activity. In comparison with reported literatures, such photocatalyst represents the excellent performance among all reported transition-metal oxides and/or transition-metal sulfides and is even superior to noble metal catalyst.
Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology
Authors: Tian Fangyun , Lewis Laura D. , Zhou David W. , Balanza Gustavo A. , Paulk Angelique C. , Zelmann Rina , Peled Noam , Soper Daniel , Santa Cruz Mercado Laura A. , Peterfreund Robert A. , Aglio Linda S. , Eskandar Emad N. , Cosgrove G. Rees , Williams Ziv M. , Richardson R. Mark , Brown Emery N. , Akeju Oluwaseun , Cash Sydney S. , Purdon Patrick L. 
Published: March 2023

AbstractKetamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by its psychotropic side effects. Ketamine is thought to act via NMDA receptors and HCN1 channels to produce brain oscillations that are related to these effects. Using human intracranial recordings, we found that ketamine produces gamma oscillations in prefrontal cortex and hippocampus, structures previously implicated in ketamine’s antidepressant effects, and a 3 Hz oscillation in posteromedial cortex, previously proposed as a mechanism for its dissociative effects. We analyzed oscillatory changes after subsequent propofol administration, whose GABAergic activity antagonizes ketamine’s NMDA-mediated disinhibition, alongside a shared HCN1 inhibitory effect, to identify dynamics attributable to NMDA-mediated disinhibition versus HCN1 inhibition. Our results suggest that ketamine engages different neural circuits in distinct frequency-dependent patterns of activity to produce its antidepressant and dissociative sensory effects. These insights may help guide the development of brain dynamic biomarkers and novel therapeutics for depression.
Factors for optimizing intervention programs for cognition in older adults: the value of exergames
Authors: Perrot Alexandra , Maillot Pauline 
Published: March 2023

AbstractThis review presents factors that could optimize the effectiveness of an intervention program on cognitive health in older adults. Combined, multi-dimensional and interactive programs appear to be relevant. On one hand, for the characteristics to be implemented in the physical dimension of a program, multimodal interventions stimulating the aerobic pathway and muscle strengthening during the solicitation of gross motor activities, seem to be interesting. On the other hand, regarding the cognitive dimension of a program, complex and variable cognitive stimuli appear to hold the greatest promise for generating cognitive benefits and the broadest transfers to untrained tasks. The field of video games also brings interesting enrichment through the gamification of situations and the feeling of immersion. However, some gray areas remain to be clarified, notably the ideal response dose, the balance between physical and cognitive solicitation and the programs’ customization.
Impact of a Mn-oxidizing bacterial strain on the dissolution and browning of a Mn-bearing potash-lime silicate glass
Authors: Valbi Valentina , Perez Anne , Verney-Carron Aurélie , Rossano Stéphanie 
Published: March 2023

AbstractThis work aims to investigate the role played by a model Mn-oxidizing bacterial strain and its exudates on the alteration of Mn-bearing potash-lime silicate glasses representative of medieval stained glass windows. Two model glasses, with or without manganese, were prepared and used for abiotic and Pseudomonas putida inoculated dissolution experiments. Results show that the presence of P. putida slows down the dissolution kinetics while changing the dissolution stoichiometry. In biotic experiments, the acidification of the solution at the beginning of the experiment favors the release of K. After a few days, a drop in Mn and P in solution is observed, retained by bacterial cells. Reciprocally, the amount of glass influences bacterial behavior. The more glass, the faster the bacterial population increases in size and produces siderophore. In the presence of the Mn-bearing glass, siderophore production is followed by the formation of brown phases, identified as Mn oxides.