bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consulting a neurosurgeon upon initial medical assessment reduces the time to the first surgery and potentially contributes to improved prognosis for glioblastoma patients
Authors: Kawauchi Daisuke , Ohno Makoto , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Omura Takaki , Yoshida Akihiko , Kubo Yuko , Igaki Hiroshi , Ichimura Koichi , Narita Yoshitaka 
Published: August 2023

Abstract

Background
The neurological status of glioblastoma patients rapidly deteriorates. We recently demonstrated that early diagnosis and surgery within 3 weeks from the initial symptoms are associated with improved survival. While glioblastoma is a semi-urgent disease, the prehospital behaviors and clinical outcomes of glioblastoma patients are poorly understood. We aimed to disclose how prehospital patient behavior influences the clinical outcomes of glioblastoma patients.

Methods
Isocitrate dehydrogenase-wildtype glioblastoma patients treated at our institution between January 2010 and December 2019 were reviewed. Patients were divided into two groups, neurosurgeon and non-neurosurgeon groups, based on the primary doctor whom patients sought for an initial evaluation. Patient demographics and prognoses were examined.

Results
Of 170 patients, 109 and 61 were classified into the neurosurgeon and non-neurosurgeon groups, respectively. The median age of neurosurgeon group was significantly younger than the non-neurosurgeon group (61 vs. 69 years old, P = 0.019) and in better performance status (preoperative Karnofsky performance status scores $\ge$80: 72.5 vs. 55.7%, P = 0.027). The neurosurgeon group exhibited a significantly shorter duration from the first hospital visit to the first surgery than the non-neurosurgeon group (18 vs. 29 days, P &lt; 0.0001). Furthermore, the overall survival of the neurosurgeon group was significantly more prolonged than that of the non-neurosurgeon group (22.9 vs. 14.0 months, P = 0.038).

Conclusion
Seeking an initial evaluation by a neurosurgeon was potentially associated with prolonged survival in glioblastoma patients. A short duration from the first hospital visit to the first surgery is essential in enhancing glioblastoma patient prognosis.
Time to deterioration of patient-reported outcomes as a surrogate of overall survival: a meta-analysis
Authors: Shahnam Adel , Nindra Udit , Desai Jayesh , Hui Rina , Buyse Marc , Hopkins Ashley M , Sorich Michael J 
Published: August 2023

AbstractBackgroundOverall survival is the optimal marker of treatment efficacy in randomized clinical trials (RCTs) but can take considerable time to mature. Progression-free survival (PFS) has served as an early surrogate of overall survival but is imperfect. Time to deterioration in quality of life (QOL) measures could be a surrogate for overall survival.MethodsPhase 3 RCTs in solid malignancies that reported overall survival, PFS, and time to deterioration in QOL or physical function published between January 1, 2010, and June 30, 2022, were evaluated. Weighted regression analysis was used to assess the relationship between PFS, time to deterioration in QOL, and time to deterioration in physical function with overall survival. The coefficient of determination (R2) was used to quantify surrogacy.ResultsIn total, 138 phase 3 RCTs were included. Of these, 47 trials evaluated immune checkpoint inhibitors and 91 investigated non–immune checkpoint inhibitor agents. Time to deterioration in QOL (137 RCTs) and time to deterioration in physical function (75 RCTs) performed similarly to PFS as surrogates for overall survival (R2 = 0.18 vs R2 = 0.19 and R2 = 0.10 vs R2 = 0.09, respectively). For immune checkpoint inhibitor studies, time to deterioration in physical function had a higher association with overall survival than with PFS (R2 = 0.38 vs R2 = 0.19), and PFS and time to deterioration in physical function did not correlate with each other (R2 = 0). When time to deterioration in physical function and PFS are used together, the coefficient of determination increased (R2 = 0.57).ConclusionsTime to deterioration in physical function appears to be an overall survival surrogate measure of particular importance for immune checkpoint inhibitor treatment efficacy. The combination of time to deterioration in physical function with PFS may enable better prediction of overall survival treatment benefit in RCTs of immune checkpoint inhibitors than either PFS or time to deterioration in physical function alone.
Extreme mass ratios and fast rotation in three massive binaries
Authors: Nazé Yaël , Britavskiy Nikolay , Rauw Gregor , Labadie-Bartz Jonathan , Simón-Díaz Sergio 
Published: August 2023

ABSTRACT
The origin of rapid rotation in massive stars remains debated, although binary interactions are now often advocated as a cause. However, the broad and shallow lines in the spectra of fast rotators make direct detection of binarity difficult. In this paper, we report on the discovery and analysis of multiplicity for three fast-rotating massive stars: HD 25631 (B3V), HD 191495 (B0V), and HD 46485 (O7V). They display strikingly similar TESS light curves, with two narrow eclipses superimposed on a sinusoidal variation due to reflection effects. We complement these photometric data by spectroscopy from various instruments (X-Shooter, Espadons, FUSE...), to further constrain the nature of these systems. The detailed analyses of these data demonstrates that the companions of the massive OB stars have low masses (∼1 M⊙) with rather large radii (2–4 R⊙) and low temperatures (&lt;15 kK). These companions display no UV signature, which would exclude a hot subdwarf nature, but disentangling of the large set of X-Shooter spectra of HD 25631 revealed the typical signature of chromospheric activity in the companion’s spectrum. In addition, despite the short orbital periods (P = 3−7 d), the fast-rotating OB-stars still display non-synchronized rotation and all systems appear young (&lt;20 Myr). This suggests that, as in a few other cases, these massive stars are paired in those systems with non-degenerate, low-mass PMS companions, implying that fast rotation would not be a consequence of a past binary interactions in their case.
The 2175 Å interstellar extinction bump: is the wavelength variable?
Authors: Wang Qian , Yang X J , Li Aigen 
Published: August 2023

ABSTRACT
The most striking characteristics of the mysterious 2175$\mathring{\rm A}$ extinction bump, the strongest spectroscopic absorption feature seen on the interstellar extinction curve, are the invariant central wavelength and variable bandwidth: its peak position at 2175$\mathring{\rm A}$ is remarkably constant, while its bandwidth varies from one line of sight to another. However, recent studies of the lines of sight towards a number of Herbig Ae/Be stars have revealed that the extinction bump exhibits substantial shifts from the canonical wavelength of 2175$\mathring{\rm A}$. In this work, we revisit these lines of sight and take a physical approach to determine the ultraviolet (UV) extinction curve for each line of sight. It is found that the wavelengths of the derived UV extinction bumps are around 2200$\mathring{\rm A}$ and the scatters are considerably smaller than those of the previous study based on the same set of Herbig Ae/Be stars, consistent with the conventional wisdom of a stable bump position. Nevertheless, the scatters are still appreciably larger than those associated with the nominal bump position of 2175$\mathring{\rm A}$. This is discussed in the context that Herbig Ae/Be stars are not well suited for interstellar extinction studies.
NuSTAR and AstroSat observations of GX 9+1: spectral and temporal studies
Authors: Thomas Neal Titus , Gudennavar S B , Bubbly S G 
Published: August 2023

ABSTRACT
We have studied the spectro-temporal properties of the neutron star low-mass X-ray binary GX 9+1 using data from NuSTAR/Focal Plane Module and AstroSat/Soft X-ray Telescope and Large Area X-ray Proportional Counter (LAXPC). The hardness–intensity diagram of the source showed it to be in the soft spectral state (banana branch) during both observations. NuSTAR spectral analysis yielded an inclination angle (θ) = 29${^{+3}_{-4}}^{\circ }$ and inner disc radius (Rin) ≤ 19 km. Assuming that the accretion disc was truncated at the Alfvén radius during the observation, the upper limits of the magnetic dipole moment (μ) and the magnetic field strength (B) at the poles of the neutron star in GX 9+1 were calculated to be 1.5 × 10 26 G cm3 and 2.1 × 10 8 G, respectively (for kA = 1). Furthermore, the thickness of the boundary layer was found to be ≃7.5 km, which yielded the radius of the neutron star to be ≤11.5 km. Flux-resolved spectral analysis with AstroSat data showed the source to be disc dominated (Fdisc/Ftotal ∼ 0.9) with a monotonic increase in mass accretion rate ($\dot{m}$) along the banana branch. The analysis also showed the presence of absorption edges at ∼1.9 and ∼2.4 keV, likely due to Si xiii and S xv, respectively. Temporal analysis with LAXPC-20 data in the 0.02–100 Hz range revealed the presence of noise components, which could be characterized by broad Lorentzian components.
Contextual Characterisation Study of Chandrayaan-3 Primary Landing Site
Authors: Karanam Durga Prasad , Bhatt Megha , A Amitabh , G Ambily , Sathyan Sachana , Misra Dibyendu , Srivastava Neeraj , Bhardwaj Anil 
Published: August 2023

Abstract
Chandrayaan-3 is an upcoming lunar mission of India aimed at soft-landing and carrying out first-ever in situ investigations at a high-latitude location on the Moon. Chandrayaan-3 consists of a propulsion module, a lander and a rover, that carry a set of payloads for conducting in-situ science experiments. In this work, contextual characterization of the primary landing site(PLS) located at 69.367621˚S, 32.348126 ̊E is carried out in terms of identification, geomorphology, composition and thermophysical context using the best-ever high-resolution datasets. Our geomorphological study indicates that the PLS is safe for landing with slope less than 4˚ in about 78% of landing area and an average elevation variation of about 169m. The spectral analysis suggests that the region must have experienced extensive space weathering. Compositional analysis indicate that the landing region has a typical highland type of soil characteristics with Mg(4.3 to 5.2 wt.%), Fe(4.2 to 4.9 wt.%), Ca(10-11 wt.%), and Ti(0.25-0.35wt.%). Thermophysical analyses show ∼30K and ∼175K variability in spatial and diurnal temperatures at the PLS- an indicative of a local terrain of distinctive thermophysical characteristics. With important science instruments onboard, Chandrayaan-3 will provide a unique opportunity towards looking at localised variations leading to an improved understanding of the lunar surface.
LMAP-06 VOLUMETRIC MODULATED ARC THERAPY CRANIOSPINAL IRRADIATION UTILIZING A VERTEBRAL BODY SPARING APPROACH: AN ALTERNATIVE APPROACH TO IMPROVE ACCESS AND MINIMIZE TOXICITY
Authors: Perlow Haley K , Matsui Jennifer K , Ewing Ashlee , Cadieux Catherine , Blakaj Dukagjin M , Beyer Sasha J , Thomas Evan M , Grecula John C , Raval Raju R , Palmer Joshua D 
Published: August 2023

Abstract
Craniospinal irradiation (CSI) is indicated for adult patients diagnosed with leptomeningeal disease (LMD). Proton-based vertebral-body-sparing (VBS) CSI has been explored with pediatric patients to minimize hematologic toxicity; however, utilization of VBS in an adult population is limited. A recent phase II trial has shown efficacy of proton-based CSI to treat non-small cell lung and breast cancer with LMD. We hypothesize that VBS-CSI utilizing volumetric modulated arc therapy (VMAT) could also effectively reduce dose to vertebral bodies and surrounding organs-at-risk (OARs), minimizing toxicity for adult patients with LMD and comparing favorably to proton-based CSI. Consecutive patients with leptomeningeal disease received VMAT VBS-CSI, 30 Gy in 10 fractions, as a part of a prospective registry. Full VMAT arcs for the brain fields matched to two spine isocenters for the upper and lower spine were created utilizing limited posterior arcs. To further decrease the vertebral body dose, an avoid entry and exit contour was created. Acute toxicity data were collected using Common Terminology Criteria for Adverse Events (CTCAE) v5. Ten adult patients were treated in this cohort. One patient experienced Grade 2 neutropenia with the remaining nine experiencing Grade 1 hematologic toxicity. Three patients experienced Grade 2 gastrointestinal toxicity. with the remaining seven experiencing Grade 1 nausea. No patient experienced Grade 3+ toxicities in this cohort. One patient experienced a 5-day delay in systemic therapy initiation due to neutropenia; otherwise, all patients planned for systemic therapy started without delay. VMAT VBS-CSI is an effective technique to reduce dose to surrounding OARs and vertebral bodies. In this study, VMAT VBS-CSI led to acceptable toxicity compared to patients treated with proton CSI on a phase 2 clinical trial. Given its promising early results, future prospective evaluation of the technique is warranted.
SDPS-11 IMPACT OF MOLECULAR MARKERS USING FISH TECHNIQUE ON GOS/SURVIVAL IN HIGH GRADE GLIOMAS IN INDIAN SCENARIO
Authors: Pathak Ashis , Brar Harman , Puri Abhishek 
Published: August 2023

Abstract

Aims
Molecular markers (MGMT, IDH and 1p/19q, MIB-1 index, TP53) are used for present day diagnosis of high-grade glial tumours. This study evaluates outcome parameters [e.g., GOS, progression free (PFS) and overall survival(OS)] in treated high grade gliomas in Indian context using FISH technique for molecular characterisation.

MATERIALS AND METHODS
This study used FISH techniques for IDH, MGMT and other IHC markers prospectively on 10 patients with high-grade gliomas, after safe maximal resection. Outcomes were noted for PFS and OS. A GOS of 1-3 (considered unfavourable); 4-5 (favourable), was documented at every 3-monthly follow-up for 2 years. The standardised detection of IDH (by FISH) and methylation profiles of tumours is the strength of the study.

RESULTS
Most (80%) patients had a GOS &gt; 13 post operatively, and none were less than 9. There was no statistically significant effect of gender, extent of resection or tumour location. IDH-1 positivity was recorded in 10%, MGMT methylation in 40%, intermediate to low MIB-1 index in 83.3%. TP53 mutations were noted in 30% cohort who had adverse outcome. The median PFS was 8.60 months. Mean survival was 12.70 months, with no molecular marker having statistically significant effects on PFS or OS. GOS of 13-15 conferred the best OS in contrast to GOS of 9-12 (16.2 months versus 7.5 months); (p = 0.001).

CONCLUSION
GOS is an easy-to-use, validated scoring system with broad applicability and high reproducibility as a quantitative benchmark for clinical assessment. Since IHC lacks standardisation, FISH, despite being costlier, was used as a diagnostic benchmark. Further research on the impact of genomic profiling, extent of resection, especially in geriatric age groups is needed, to formulate an algorithm for optimal management.
Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia
Authors: Gou Mengzhuang , Chen Wenjin , Li Yanli , Chen Song , Feng Wei , Pan Shujuan , Luo Xingguang , Tan Shuping , Tian Baopeng , Li Wei , Tong Jinghui , Zhou Yanfang , Li Hongna , Yu Ting , Wang Zhiren , Zhang Ping , Huang Junchao , Kochunov Peter , Tian Li , Li Chiang-Shan R , Hong L Elliot , Tan Yunlong 
Published: August 2023

Abstract

Background and Hypothesis
Low-grade neural and peripheral inflammation are among the proposed pathophysiological mechanisms of schizophrenia. White matter impairment is one of the more consistent findings in schizophrenia but the underlying mechanism remains obscure. Many cerebral white matter components are sensitive to neuroinflammatory conditions that can result in demyelination, altered oligodendrocyte differentiation, and other changes. We tested the hypothesis that altered immune-inflammatory response system (IRS) and compensatory immune-regulatory reflex system (IRS/CIRS) dynamics are associated with reduced white matter integrity in patients with schizophrenia.

Study Design
Patients with schizophrenia (SCZ, 70M/50F, age = 40.76 ± 13.10) and healthy controls (HCs, 38M/27F, age = 37.48 ± 12.31) underwent neuroimaging and plasma collection. A panel of cytokines were assessed using enzyme-linked immunosorbent assay. White matter integrity was measured by fractional anisotropy (FA) from diffusion tensor imaging using a 3-T Prisma MRI scanner. The cytokines were used to generate 3 composite scores: IRS, CIRS, and IRS/CIRS ratio.

Study Results
The IRS/CIRS ratio in SCZ was significantly higher than that in HCs (P = .009). SCZ had a significantly lower whole-brain white matter average FA (P &lt; .001), and genu of corpus callosum (GCC) was the most affected white matter tract and its FA was significantly associated with IRS/CIRS (r = 0.29, P = .002). FA of GCC was negatively associated with negative symptom scores in SCZ (r = −0.23, P = .016). There was no mediation effect taking FA of GCC as mediator, for that IRS/CIRS was not associated with negative symptom score significantly (P = .217) in SCZ.

Conclusions
Elevated IRS/CIRS might partly account for the severity of negative symptoms through targeting the integrity of GCC.
College Choices, Choice Dilemmas: Black Advantaged Parents’ Views of Their Children’s College Options
Authors: Faulk Deborwah 
Published: August 2023

AbstractStudies investigating college views largely neglect the Black advantaged and specifically the role of parents in the college search process. Drawing on interviews with upper, upper-middle-, and middle-class parents, this paper investigates how Black advantaged parents view their children’s college options. In an anti-black and credentialed society, parents contend with the consequences of where their children enroll in college and the names their degrees bear. Black advantaged parents’ views of their children’s college options reflect a set of dilemmas relative to college choices. As college graduates, parents recognize that degrees from HBCUs are weighed down by racial stigma and institutional anti-blackness. Fears about anti-black perceptions of HBCUs fuel parental concerns about racial discrimination post-graduation. Yet, parents also recognize that as students on historically white campuses their children are at risk of experiences with anti-black racism while enrolled in college. This article describes the challenge of antiblackness as multi-dimensional, impacting parents’ attention both to their children’s experiences as graduates and as students. This paper offers implications for black parenting, decision-making, and higher education.
Maternal Employment and Childcare Use from an Intersectional Perspective: Stratification along Class, Contractual and Gender Lines in Denmark, France, Germany, Italy, Sweden and the UK
Authors: Ferragina Emanuele , Magalini Edoardo 
Published: August 2023

Abstract
Connecting streams of feminist and comparative social policy literature, this article investigates stratification in maternal employment and childcare use along class, contractual, and gender lines across six countries (Denmark, France, Germany, Italy, Sweden, and the United Kingdom) and five family policy models. Detailing the different stratifying factors that intervene in the relation between maternal employment and childcare use offers a concrete analysis of the complex link between social reproduction and work. Employing multivariate regressions and EU-SILC (2007–2018) data, it provides an intersectional perspective to the literature. First, we observe a process of formalization in childcare use with a parallel reduction of nonformal care for couples; this process is slower for single mothers. Second, we document a paradox in relation to the social investment approach: the relation between childcare use and maternal employment is stronger in countries that recently expanded childcare to modify their male-breadwinner orientation, but in these countries childcare use is more stratified along class/contract types, a concern for the outcomes of social investment strategies outside of Scandinavia. Being out of work, being in a lower social class, fulfilling domestic tasks and/or care activities, and having an atypical contract negatively correlates with childcare use in most countries. Third, households where partners have more similar earning levels use childcare to a greater extent. The article also provides models employing different dependent and independent variables, alternative family structures, full and part-time work, formal and nonformal childcare, and rich country details.
A Hydroponic-Based Bioassay to Facilitate Plasmodiophora brassicae Phenotyping
Authors: Salih Rasha , Brochu Anne-Sophie , Labbé Caroline , Strelkov Stephen E. , Franke Coreen , Bélanger Richard , Pérez-López Edel 
Published: August 2023

Clubroot, caused by the obligate parasite Plasmodiophora brassicae, is one of the most devastating diseases affecting the canola/oilseed rape (Brassica napus) industry worldwide. Currently, the planting of clubroot-resistant (CR) cultivars is the most effective strategy used to restrict the spread and the economic losses linked to the disease. However, virulent P. brassicae isolates have been able to infect many of the currently available CR cultivars, and the options to manage the disease are becoming limited. Another challenge has been achieving consistency in evaluating host reactions to P. brassicae infection, with most bioassays conducted in soil and/or potting medium, which requires significant space and can be labor intensive. Visual scoring of clubroot symptom development can also be influenced by user bias. Here, we have developed a hydroponic bioassay using well-characterized P. brassicae single-spore isolates representative of clubroot virulence in Canada, as well as field isolates from three Canadian provinces in combination with canola inbred homozygous lines carrying resistance genetics representative of CR cultivars available to growers in Canada. To improve the efficiency and consistency of disease assessment, symptom severity scores were compared with clubroot evaluations based on the scanned root area. According to the results, this bioassay offers a reliable, less expensive, and reproducible option to evaluate P. brassicae virulence, as well as to identify which canola resistance profile(s) may be effective against particular isolates. This bioassay will contribute to the breeding of new CR canola cultivars and the identification of virulence genes in P. brassicae that could trigger resistance and that have been very elusive to this day. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .