bluuebunny/crossref_metadata_2025_split huggingface dataset:
Same Day Discharge After Mastectomy and Immediate Implant-Based Breast Reconstruction
Authors: Brantley Rebecca A. , Thuman Jenna , Hudson Todd , Gregoski Mathew J. , Scomacao Isis , Herrera Fernando A. 
Published: June 2023

Introduction
Currently, overnight admission after immediate implant-based breast reconstruction (IBR) is the standard of care. Our study aims to analyze the safety, feasibility, and outcomes of immediate IBR with same-day discharge as compared with the standard overnight stay.

Methods
The 2015–2020 National Surgical Quality Improvement Program database was reviewed to identify all patients undergoing mastectomy with immediate IBR for malignant breast disease. Patients were stratified into study (patients discharged day of surgery) and control (patients admitted after surgery) groups. Patient demographics, comorbidities, surgical characteristics, implant type, wound complications, readmission, and reoperation rates were collected and analyzed. Univariate and multivariate logistic regression was used to determine independent predictors of same-day discharge versus admission. In addition, Pearson χ2 test was used for comparison of proportions and t test was used for continuous variables unless distributions required subsequent nonparametric analyses. Statistical significance was defined as a P value less than 0.05.

Results
A total of 21,923 cases were identified. The study group included 1361 patients discharged same day and the control group included 20,562 patient s admitted for average of 1.4 days (range, 1–86). Average age was 51 years for both groups. Average body mass index for the study group 27 and 28 kg/m2 for the control group, respectively. Total wound complication rates were similar (4.5% study, 4.3% control, P = 0.72). Reoperation rates were lower with same-day discharge (5.7% study, 6.8% control, P = 0.105), though not statistically significant. However, same-day discharge patients had a significantly lower readmission rate compared with the control (2.3% study, 4.2% control, P = 0.001).

Conclusion
National Surgical Quality Improvement Program data analysis over a 6-year period reveals that immediate IBR with same-day discharge is associated with a significantly lower readmission rate when compared with the standard overnight stay. The comparable complication profiles show that immediate IBR with same-day discharge is safe, potentially benefiting both patients and hospitals.
Creatinine Clearance Predicts the Goal Enoxaparin Dose in Traumatic Brain Injury
Authors: Park Greigory , Dhillon Navpreet K. , Fierro Nicole M. , Drevets Peter , Stupinski John , Ley Eric J. 
Published: June 2023

Abstract

Background
Patients with traumatic brain injury (TBI) are at high risk of venous thromboembolism (VTE). Recent guidelines recommend starting TBI patients on enoxaparin 30 mg twice daily and then considering weight-based dosing. Creatinine clearance may be better than weight for patients when considering high and low enoxaparin dose requirements. We hypothesize that creatinine clearance (CrCl) predicts goal enoxaparin dose better than weight-based dosing.

Methods
A retrospective review was conducted on patients admitted to an urban, academic Level 1 trauma center from August 2017 to February 2020. Patients were included if greater than 18 years, admitted longer than 48 hours, and head and neck AIS ≥ 3. Patients were excluded if they did not have TBI, if they received DVT prophylaxis other than enoxaparin q12 hour dosing, if no anti-Xa levels were drawn, or if the goal anti-Xa level was not reached. Patients were grouped into dosing cohorts based on dose of enoxaparin required to reach goal. Pearsons correlation was used to compare mean CrCl and mean weight across dosing cohorts.

Results
A total of 120 patients met inclusion and exclusion criteria, mean age was 47 years and 68% of patients were male. The mean hospital length of stay was 24 days. There were 5 (4.2%) DVT, no pulmonary embolism, and 5 (4.2%) patients died. Mean CrCl increased significantly with increased dosing of enoxaparin, Pearsons correlation coefficient of 0.484 (p < 0.001). Weight on admission also increased with increasing enoxaparin dose requirements, with Pearsons correlation coefficient of 0.411 (p < 0.001).

Conclusion
CrCl predicts goal enoxaparin dose in TBI better than a weight-based dosing strategy. Further research with a larger patient population is required to further validate CrCl values to guide enoxaparin dosing.

Level of Evidence
Level 3, retrospective study.
Botulinum Toxins and Zinc: From Theory to Practice—A Systematic Review
Authors: Mallat Farid , Kaikati Jerome , Kechichian Elio 
Published: June 2023

Objective
The aims of this study were to determine whether zinc supplementation affects botulinum toxin's effect and longevity and to establish a transition from the molecular to the clinical aspect.

Methods
We conducted a systematic review in which we included all published studies on PubMed and Embase using the combination of the following terms: “zinc” AND (botox OR botulinum OR onabotulinumtoxinA OR abobotulinumtoxinA OR incobotulinumtoxinA).

Results
From the 260 yielded articles, 3 randomized control trials and 1 case report were retained. Three of them found a significant improvement with zinc supplementation in the toxin's effect and longevity. This was observed in neurological conditions and cosmetic uses.

Conclusions
Zinc supplementation could be an interesting asset in the potentialization of botulinum neurotoxin effect and longevity. Larger clinical trials and objective measurement tools should be used to further defining the role of zinc in maximizing botulinum neurotoxin effect.
Aripiprazole-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Case Study
Authors: Coulson Christian J. , Yrastorza-Daghman Marie 
Published: June 2023

Objectives
The use of medications in management of disease is an integral part of treatment to patients in both the inpatient and outpatient setting; however, these medications often have risk of adverse effects associated with their benefits of use. Adverse cutaneous reactions are one of the most frequent types of adverse drug reactions. Two major phenotypes of cutaneous adverse drug reactions are toxic epidermal necrolysis (TEN), and Stevens-Johnson syndrome (SJS). Aripiprazole is an antipsychotic drug with a well-documented profile of adverse effects for physicians to be aware of; however, SJS/TEN is not known to be included in that profile.

Methods
The authors encountered a case of aripiprazole-induced SJS/TEN and used the electronic medical records from this encounter to summarize this novel case in detail. Existing literature was reviewed using public databases for evaluation of similar cases.

Results
We present a case of SJS/TEN induced by aripiprazole use for bipolar disorder, type 1, which is not an adverse effect of the drug that has been documented in the literature. We include patient history, hospital course, images, and treatment of disease throughout admission as well as a thorough discussion of the topic.

Conclusions
We present a case of an adverse drug reaction that has not previously been documented in the literature with the goal of informing readers of the potential for this life-threatening atypical effect and the severity of disease it may cause.
Molecular Epidemiology of Antimicrobial Resistance in Central Africa: A Systematic Review
Authors: DIKOUMBA Annicet-Clotaire , ONANGA Richard , MANGOUKA Laurette G. , BOUNDENGA Larson , NGOUNGOU Edgard-Brice , GODREUIL Sylvain 
Published: June 2023

Background: In Central Africa, it is difficult to fight against antibiotic resistance, because of a lack of data and information on bacterial resistance, due to the low number of studies carried out in the field. To fill this gap, we carried out a systematic review of the various studies, and devise a molecular epidemiology of antimicrobial resistance from humans, animals and the environmental samples.Method: A systematic search of all publications from 2005 to 2020 on bacterial resistance in Central Africa was performed on Pubmed, Google scholar and African journals online. All circulating resistance genes, prevalence and genetic carriers of these resistances were collected. The study area was limited to the 9 countries of Central Africa. Results: Five hundred seventeen studies were identified through a literature search, and sixty studies carried out in 8 countries were included. Among all articles included, 43 articles were from human. Our study revealed not only the circulation of beta-lactamase and carbapenemase genes, but also several other types of resistance genes. To finish, we noticed that some studies reported mobile genetic elements such as integrons, transposons, plasmids, or chromosomes.Conclusion: The scarcity of data poses difficulties in the implementation of effective strategies in the fight against antibiotic resistance, which requires a health policy in a "One Health" approach.
Using visual attention estimation on videos for automated prediction of autism spectrum disorder and symptom severity in preschool children
Authors: de Belen Ryan Anthony J. , Eapen Valsamma , Bednarz Tomasz , Sowmya Arcot 
Published: June 2023

AbstractAtypical visual attention in individuals with autism spectrum disorders (ASD) has been utilised as a unique diagnosis criterion in previous research. This paper presents a novel approach to the automatic and quantitative screening of ASD as well as symptom severity prediction in preschool children. We develop a novel computational pipeline that extracts learned features from a dynamic visual stimulus to classify ASD children and predict the level of ASD-related symptoms. Experimental results demonstrate promising performance that is superior to using handcrafted features and machine learning algorithms, in terms of evaluation metrics used in diagnostic tests. Using a leave-one-out cross-validation approach, we obtained an accuracy of 94.59%, a sensitivity of 100%, a specificity of 76.47% and an area under the receiver operating characteristic curve (AUC) of 96% for ASD classification. In addition, we obtained an accuracy of 94.74%, a sensitivity of 87.50%, a specificity of 100% and an AUC of 99% for ASD symptom severity prediction.
Protocol for piloting a phone-based web survey to elicit barriers to accessing triage camps within community-based, Peek-powered eye screening programmes
Authors: Allen Luke , Mishra Sailesh , Tlhajoane Malebogo , Ratshaa Bakgaki , Macleod Dave , Chroston Hannah , Nkomazana Oathokwa , Bastawrous Andrew 
Published: June 2023

Pilot study summaryTitlePiloting a phone-based web survey to elicit barriers to accessing triage camps within community-based, Peek-powered eye screening programmesDesignPilot test of an online survey sent via SMS to 1,600 parents/guardians of children who did not attend eye clinics having been found to have an eye need at school screening. We will perform the same pilot twice; once in Botswana and once in NepalAimsTo quantify the response rate among 16 different subgroups of recipients according to gender, location, wealth and assets.Note that we are not concerned with the responses at this pilot phase – only the suitability of the medium.PopulationParents/guardians of children who did not attend screening within Botswana’s Peek-powered national school-based ‘Pono Yame’ programme, and participants in Nepal’s Peek-powered community screening programmeInterventionA four-question online survey exploring barriers to attendance. The hyperlink will be sent via SMS. Non-responders will receive a single follow-up reminder 7 days later.Outcome measureCumulative survey completion rates over the 31 days that follow the original SMS invitation.DurationAll survey invitations will be sent on the same day. As such, the pilot will last 31 days.
Effects of participatory organizational interventions on mental health and work performance: A protocol for systematic review and meta-analysis
Authors: Iida Mako , Sakuraya Asuka , Imamura Kotaro , Asaoka Hiroki , Arima Hideaki , Ando Emiko , Inoue Akiomi , Inoue Reiko , Iwanaga Mai , Eguchi Hisashi , Otsuka Yasumasa , Kobayashi Yuka , Komase Yu , Kuribayashi Kazuto , Sasaki Natsu , Tsuno Kanami , Hino Ayako , Watanabe Kazuhiro , Ebara Takeshi , Shimazu Akihito , Kawakami Norito , Tsutsumi Akizumi 
Published: June 2023

AbstractIntroductionParticipatory organizational interventions to improve psychosocial working conditions are important for a safe and healthy work environment. However, there are few systematic reviews or meta-analyses investigating the effects of these interventions on workers’ mental health and work-related outcomes. We apply the protocol for systematic review and meta-analysis to examine the effect of participatory organizational intervention on mental health and work performance.Methods and analysisThe participants, interventions, comparisons, and outcomes (PICO) of the studies in this systematic review and meta-analysis were defined as follows: (P) inclusion of all workers, (I) participatory organizational intervention, (C) treatment as usual or no intervention (including waitlist control), and (O) mental health and work performance. Published studies will be searched using the following electronic databases: PubMed, EMBASE, PsycINFO, PsycARTICLES, and Japan Medical Abstracts Society. Study selection and the risk of bias assessment will be performed independently by two reviewers. A meta-analysis will be performed to statistically synthesize the included studies.Ethics and disseminationThis study does not require ethical approval. The findings and results will be submitted to and published in a scientific peer-reviewed journal.Registration detailsThe study protocol was registered at the UMIN registry (registration number: UMIN000049453).
Timing and Predictors of Loss of Infectivity among Healthcare Workers with Primary and Recurrent COVID-19: a Prospective Observational Cohort Study
Authors: Dzieciolowska Stefka , Charest Hugues , Roy Tonya , Fafard Judith , Carazo Sara , Levade Ines , Longtin Jean , Parkes Leighanne , Beaulac Sylvie Nancy , Villeneuve Jasmin , Savard Patrice , Corbeil Jacques , Serres Gaston De , Longtin Yves 
Published: June 2023

AbstractBackgroundThere is a need to understand the duration of infectivity of primary and recurrent COVID-19 and identify predictors of loss of infectivity.MethodsProspective observational cohort study with serial viral culture, rapid antigen detection test (RADT) and RT-PCR on nasopharyngeal specimens of healthcare workers with COVID-19. The primary outcome was viral culture positivity as indicative of infectivity. Predictors of loss of infectivity were determined using multivariate regression model. The performance of the US CDC criteria (fever resolution, symptom improvement and negative RADT) to predict loss of infectivity was also investigated.Results121 participants (91 female [79.3%]; average age, 40 years) were enrolled. Most (n=107, 88.4%) had received ≥3 SARS-CoV-2 vaccine doses, and 20 (16.5%) had COVID-19 previously. Viral culture positivity decreased from 71.9% (87/121) on day 5 of infection to 18.2% (22/121) on day 10. Participants with recurrent COVID-19 had a lower likelihood of infectivity than those with primary COVID-19 at each follow-up (day 5 OR, 0.14; p<0.001]; day 7 OR, 0.04; p=0.003]) and were all non-infective by day 10 (p=0.02). Independent predictors of infectivity included prior COVID-19 (adjusted OR [aOR] on day 5, 0.005; p=0.003), a RT-PCR Ct value <23 (aOR on day 5, 22.75; p<0.001), but not symptom improvement or RADT result.The CDC criteria would identify 36% (24/67) of all non-infectious individuals on Day 7. However, 17% (5/29) of those meeting all the criteria had a positive viral culture.ConclusionsInfectivity of recurrent COVID-19 is shorter than primary infections. Loss of infectivity algorithms could be optimized.
The Transcriptomics Pain Signature Database
Authors: Jahangiri Esfahani Sahel , Parisien Marc , Surbey Calvin , Diatchenko Luda 
Published: June 2023

ABSTRACTThe availability of convenient tools is critical for the efficient analyses of fast-generated omics-wide-level studies. Here, we describe the creation, characterization, and applications of the Pain Signatures Database (TPSDB), a comprehensive database containing the results of differential gene expression analyses from 338 full transcriptomic datasets for pain-related phenotypes. The database allows searching for a specific gene(s), pathway(s), or SNP(s), or downloading the raw data for hypothesis-free analysis. We took advantage of this unique dataset of multiple pain transcriptomics in several ways. The pathway analyses found the cytokine production regulation and innate immune response the most frequently shared pathways across tissues and conditions. A machine learning-based approach across datasets identified RNA biomarkers for inflammatory and neuropathic pain in rodent dorsal root ganglion (DRG) with high certainty. Finally, functional annotation of pain-related GWAS results demonstrated that differentially expressed genes can be more informative than the general tissue-specific genes from DRG or spinal cord in partitioning heritability analyses.
Modified Technique for Dissection of Working Space in Retroperitoneal Laparoscopic Surgery
Authors: Xu Xiaofeng , Cheng Wen , Liu Zhe , Shi Changjie , Da Jianping , Zhou Xiumin , Ge Jingping 
Published: June 2023

AbstractIntroductionThe existing techniques to creat working space for retroperitoneal laparoscopic surgery are often accompanied by air leakage or poor visibility due to blood and fat tissues smudging during dissection.This single-center experience describes a modified dissection technique to create a retroperitoneal working space during laparoscopic surgery.Materials and MethodsFrom May 2021 to December 2022, we performed a modified dissection technique to create a retroperitoneal working space prior retroperitoneal laparoscopic surgery in 47 patients. During the procedure, laparoscopic dissection is successively performed. The retroperitoneum is initially accessed by puncturing the trocar through a 10-mm transverse skin incision in the midaxillary line. Under endoscopic monitoring, the tip of the trocar is adjusted to a relative avascular layer between the transversus abdominis muscle and the pararenal fat. Laparoscopic dissection is performed to develop until the working space is fully established. All data referring to patient demographics, surgery, dilation-related complication, and perioperative outcomes were collected retrospectively.ResultsIn all cases, a satisfactory retroperitoneal space was created for surgery. The median time of creating retroperitoneal working space was 6 (IQR:5,7) minutes. No dissection-related complications were noted within a median follow-up period of 9 (IQR:7,15) months.ConclusionModified retroperitoneal dissection with laparoscopy is a safe, simple, effective, and minimally invasive technique. It provides an adequate working space and an excellent view without obvious bleeding.
Is there an association between clinician behavioural factors, and the experience of pain in a dental setting? A Scoping Review
Authors: Tang Belinda , Ting Jasmine , Brown Rachel , Nathan Sandhya , Ashton-James Claire , Sadr Atieh , Gholamrezaei Ali 
Published: June 2023

AbstractBackgroundEffective management of pain is critical in a dental setting, and insufficient pain management can lead to anxiety in patients and hesitancy to seek further dental help. Currently, there are no existing scoping or systematic reviews discussing the impact of clinician behavioural factors on pain perception, thus highlighting the need for it.AimsThe aim of this scoping review is two-fold: to analyse the scope of current evidence surrounding the association between clinician behaviour and pain experienced in the dental setting, and to identify areas where further research is needed.MethodologyA list of search terms and subject headings was developed for Pubmed, PsycINFO and Embase to conduct pilot searches. Duplicate articles were removed, and each article screened in accordance with pre-established inclusion and exclusion criteria. Relevant articles were assessed using a data extraction form. Information was analysed to determine the scope of current evidence and areas where further study is needed.ResultsDentist behaviour has a significant impact on the patient’s pain experience, and techniques to minimise pain include empathy, being calm and non-judgemental, and providing clear information to patients about treatment. Following up the patient after treatment, via a phone call or text message, reduces pain experience. Increased levels of dental anxiety have been shown to increase dental pain, and therefore it is important that clinicians implement behaviours to reduce dental anxiety in order to reduce pain.ConclusionNumerous studies have shown the association between clinician behavioural factors and the perception of pain in the dental setting. There are various techniques dentists can utilise to improve the pain experience for their patients, including displaying a warm empathetic demeanour, appropriately managing dentally anxious patients, and utilising non-judgemental communication skills. However, there are some areas where further research is needed.HighlightsClinician behaviour can be modified to alter the perception of pain in a dental settingVarious studies outline techniques that a dentist can use to improve a patient’s pain experienceFurther research is required for chronic orofacial pain, phobic patients and patients with special needs
The TOR signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity inAspergillus flavus
Authors: Li Guoqi , Cao Xiaohong , Tumukunde Elisabeth , Zeng Qianhua , Wang Shihua 
Published: June 2023

AbstractThe target of rapamycin (TOR) signaling pathway is highly conserved and plays a crucial role in diverse biological processes in eukaryotes. Despite its significance, the underlying mechanism of the TOR pathway inA. flavusremains elusive. In this study, we comprehensively analyzed the TOR signaling pathway inA. flavusby identifying and characterizing nine genes that encode distinct components of this pathway. The FK506-binding protein Fkbp3 and its lysine succinylation are important for aflatoxin production and rapamycin resistance. The TorA kinase plays a pivotal role in the regulation of growth, spore production, aflatoxin biosynthesis, and responses to rapamycin and cell membrane stress. As a significant downstream effector molecule of the TorA kinase, the Sch9 kinase regulates aflatoxin B1(AFB1) synthesis, osmotic and calcium stress response inA. flavus,and this regulation is mediated through its S_TKc, S_TK_X domains, and the ATP binding site at K340. We also showed that the Sch9 kinase may have a regulatory impact on the high-osmolarity glycerol (HOG) signaling pathway. TapA and TipA, the other downstream components of the TorA kinase, play a significant role in regulating cell wall stress response inA. flavus. Moreover, the members of the TapA-phosphatase complexes, SitA and Ppg1, are important for various biological processes inA. flavus, including vegetative growth, sclerotia formation, AFB1biosynthesis, and pathogenicity. We also demonstrated that SitA and Ppg1 are involved in regulating lipid droplets (LDs) biogenesis and cell wall integrity (CWI) signaling pathways. In addition, another phosphatase complex, Nem1/Spo7, plays critical roles in hyphal development, conidiation, aflatoxin production, and lipid droplets biogenesis. Collectively, our study has provided important insight into the regulatory network of the TOR signaling pathway and has elucidated the underlying molecular mechanisms of aflatoxin biosynthesis inA. flavus.