bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher bone cement volume in total knee arthroplasty lowers the risk of postoperative radiolucent lines
Authors: Keintzel Maximilian , Smolle Maria A. , Staats Kevin , Böhler Christoph , Windhager Reinhard , Koutp Amir , Leithner Andreas , Donner Stefanie , Perka Carsten , Reiner Tobias , Renkawitz Tobias , Leica Alexandra , Sava Manuel , Hirschmann Michael , Sadoghi Patrick 
Published: January 2025

AbstractPurpose>The aim of this multicenter study was to analyze the potential impact of patient demographics and cementation technique towards the development of radiolucent lines (RLLs) in primary total knee arthroplasty (TKA). It was hypothesized that cementation techniques, including higher cement volume, double‐layer cementation technique and hardening in full extension, reduce RLL incidence by improving stability, whereas demographic factors such as age, BMI and smoking may increase RLL risk by affecting bone quality and mechanical loading.MethodsAltogether, 776 patients (median age: 70.7 years; 39.2% males) underwent TKA at five tertiary orthopaedic centres between 11/2013 and 04/2023. X‐rays were analyzed retrospectively for the evaluation of RLLs taken between 6 and 36 months from surgery. RLLs on anterior–posterior and lateral X‐rays taken at a median of 14 months (range: 6–36) from primary surgery were evaluated using the Knee Society roentgenographic evaluation and scoring system. Potential associations of demographics and cementation technique on the occurrence of RLLs during follow‐up were analyzed with uni‐ and multivariate logistic regression models.ResultsThe overall incidence of RLLs around the TKA amounted to 37.4% (n = 290), with the tibial component (29.4%) being more commonly affected than the femoral component (15.0%). Patient age, gender, BMI and smoking habits were not significantly associated with higher incidence of RLLs (p > 0.05). The amount of cement used (odds ratio: 0.99; 95% confidence interval: 0.98–0.99; p = 0.028) was independently associated with a lower incidence of RLLs, irrespective of the double‐ versus single‐layer cementation technique, cement hardening in full extension and time required for the X‐ray.ConclusionsNo influence of demographic data on the incidence of RLL was found, yet specific cementation techniques appeared beneficial. Future studies with longer follow‐up periods are required to provide further insight into the herein‐made preliminary findings and to assess potential associations with long‐term aseptic loosening rates.Level of EvidenceLevel III, retrospective observational study.
Comparing Otolaryngology Subspecialties' Changes in Medicare Reimbursement From 2013 to 2024
Authors: Dorius Alexander , Allen Wesley , Bateman Carson , Demke Joshua , Idicula Winslo 
Published: January 2025

ObjectiveIdentify differences in Medicare reimbursement changes for general otolaryngology, pediatric otolaryngology, head and neck oncology, laryngology, rhinology, otology, facial plastic and reconstructive surgery, and sleep surgery subspecialties from 2013 to 2024.MethodsSubspecialty‐based procedures' facility prices and relative value units (RVUs) were sourced from the Centers for Medicare & Medicaid Services' Physician Fee Schedule. Prices were adjusted for inflation, and the average percent change in facility price and RVUs for each subspecialty was calculated. Each subspecialty's average inflation‐adjusted, facility price change was compared to general otolaryngology using t‐tests, and differences between subspecialties were assessed using Dunn's test.ResultsFrom 2013 to 2024, general otolaryngology's average percent change was −29.9% and significantly differed from facial plastic and reconstructive surgery (−26.4% [−5.5 to −0.7%]; p = 0.011) and sleep surgery (−23.7% [−19.2 to −2.2%]; p = 0.016). Rhinology (−32.5% [−1.3 to 6.1%]), otology (−30.2% [−6.5 to 7.6%]), laryngology (−29.3 [−4.2 to 2.1%]), head and neck (−27.4% [−5.7 to 0.2%]), and pediatric otolaryngology (−25.8% [−14.6 to 3.8%]) also decreased drastically but were not significantly different from general otolaryngology. For the multiple comparisons test, rhinology was statistically different from sleep surgery and facial plastic and reconstructive surgery.ConclusionGeneral otolaryngology and rhinology were more negatively affected due to changes in work and practice expense RVUs. Universal decreases were due to inflation and legislative reductions to the conversion factor. Medicare's budget constraints, potential effects on access to otolaryngology services, and continuing inflation warrant lobbying efforts to address these changes to maintain financial viability.Level of EvidenceNA Laryngoscope, 2025
The impact of surgical margins in managing regional metastases in cutaneous squamous cell carcinoma of the head and neck
Authors: Braude Rachel , Manzie Timothy G.H. , Clark Jonathan R. , Shannon Kerwin , Palme Carsten E. , Elliott Michael , Wykes James , Ch'ng Sydney , Gupta Ruta , Cheung Veronica , Low Tsu‐Hui 
Published: January 2025

BackgroundRegional metastasis occurs in 5% of cutaneous squamous cell carcinoma (cSCC). The aim of this study is to assess the impact of margin status of regional metastases on survival.MethodsA retrospective review of 401 patients with nodal metastases from cSCC. Margin status of nodal metastases was classified as clear (>1 mm), close (<1 mm), or involved. Cox regression and Kaplan–Meier methods were used to assess associations with overall and disease‐specific survival (OS and DSS).ResultsOf the 401 patients with nodal metastases (median age 75, 85.3% male), 43.6% had involved margins, 27.4% had close margins, and 28.9% had clear margins. Involved margins were significantly associated with reduced OS and DSS on univariable analysis. Multivariable analysis confirmed that involved margins independently predicted worse DSS (HR 1.92, 95% CI 1.15–3.19, p = 0.01). Other independent prognostic factors included size of deposit (HR 1.02, 95% CI 1.01–1.04, p < 0.001), number of deposits (HR 1.05, 95% CI 1.02–1.08, p < 0.001), and the presence of perineural invasion (HR 1.84, 95% CI 1.14–2.98, p = 0.01).ConclusionsClear surgical margins during the removal of regional metastases of cSCC improves survival outcomes. This study highlights the importance of careful preoperative evaluation to achieve a complete (R0) surgical resection.Level of EvidenceLevel 3 Laryngoscope, 2025
Prognostic value of inflammation and nutritional indicators for sinonasal squamous cell carcinoma: A single‐center retrospective study
Authors: Wu Ce , Qi Zhiyu , Chen Jiahong , Yan Xudong , Li Shunke , Wang Lin , Yu Longgang , Jiang Yan 
Published: January 2025

AbstractIntroductionSystemic inflammatory and nutritional markers are associated with the prognosis of various cancers. However, their association with sinonasal squamous cell carcinoma (SNSCC) prognosis remains unclear. This study aimed to identify systemic inflammatory and nutritional markers associated with the postoperative prognosis of patients with SNSCC and to clarify the clinical value of these markers.Materials and methodsData from 129 patients with SNSCC were included. The optimal prognostic systemic inflammatory and nutritional markers were identified using the area under the curve. The prognostic value was evaluated using COX regression and subgroup analyses; a nomogram was built based on these data.ResultsThe advanced lung cancer inflammation index (ALI) and systemic immune‐inflammatory index (SII) had higher prognostic values than the other indices; their cut‐off values were 27.80 and 791.35, respectively. The nomogram included tumor stage, ALI, and tumor primary site; the calibration and decision curves indicated that the model had good clinical value.ConclusionThe ALI and SII have potential prognostic value for postoperative patients with SNSCC. The nomogram constructed in this study could be used as a tool to assist physicians in making clinical decisions.Level of evidence4.
4D Bioprinting: Keeping the Technology Alive
Authors: Imrie Patrick , Jin Jianyong 
Published: January 2025

Abstract4D bioprinting is a groundbreaking technology with potential to revolutionize healthcare. It is based on additive manufacturing technologies, which are used to fabricate dynamic prosthetics and devices from biologically compatible smart materials that respond to stimuli. The ultimate end of 4D bioprinting is the creation of an artificial organ that perfectly mimics the functional movements of a native organ and is fully integrated within the human body. In this perspective, two phases are identified toward this end. The first is minimally invasive surgery (MIS) using shape memory composites stimulated by near‐infrared (NIR) light and/or magnetic fields. The second is dynamic tissue engineering (DTE) with activation by biological stimuli.
Disseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy
Authors: Gong Fangchen , Zheng Xiangtao , Zhao Shanzhi , Liu Huan , Chen Erzhen , Xie Rongli , Li Ranran , Chen Ying 
Published: January 2025

AbstractDisseminated intravascular coagulation (DIC) is a complex and serious condition characterized by widespread activation of the coagulation cascade, resulting in both thrombosis and bleeding. This review aims to provide a comprehensive overview of DIC, emphasizing its clinical significance and the need for improved management strategies. We explore the primary causes of DIC, including sepsis, trauma, malignancies, and obstetric complications, which trigger an overactive coagulation response. At the molecular level, DIC is marked by excessive thrombin generation, leading to platelet and fibrinogen activation while simultaneously depleting clotting factors, creating a paradoxical bleeding tendency. Diagnosing DIC is challenging and relies on a combination of existing diagnostic criteria and laboratory tests. Treatment strategies focus on addressing the underlying causes and may involve supportive care, anticoagulation therapy, and other supportive measures. Recent advances in understanding the pathophysiology of DIC are paving the way for more targeted therapeutic approaches. This review highlights the critical need for ongoing research to enhance diagnostic accuracy and treatment efficacy, ultimately improving patient outcomes in those affected by DIC.
Regularization of the Time‐Fractional Order SchröDinger Problem by Using the Mollification Regularization Method
Authors: Yang Lan , Zhu Lin , He Shangqin , Zhao Bingxin 
Published: January 2025

ABSTRACTThis study investigates the solution of an ill‐posed time‐fractional order Schrödinger equation using a mollification regularization technique of the Dirichlet kernel. The Dirichlet regularized solution is obtained through convolution of the Dirichlet kernel with real measured data. Estimations of convergence are derived based on parameter selection criteria of a priori and a posteriori. The efficiency of the methodology was successfully verified by simulation tests.
Modeling of Data Transmission in Polymer Optical Fibers Using DMT and Machine Learning Techniques
Authors: Gois Jonathan N. , Sampaio Flavio A. N. , Haddad Diego B. , Neto Luiz Anet , Silva Vinicius N. H. , Ferreira Tadeu N. 
Published: January 2025

ABSTRACTIn local networks and other short links, polymeric optical fiber may be used due to its mechanical properties; however, some undesired and strong effects appear in these environments. This work proposes three different models to fine‐tune the electrical parameters of discrete multi‐tone (DMT) modulation to predict the signal‐to‐noise rate (SNR) over each subcarrier used with a 560 nm central wavelength. Considering the present setup, the devised models achieve some bold results, demonstrating the possibility of explaining more than 99% of the experimental data, in the best scenario. Several models are mathematically fit to obtain distinct adjustments for the nonlinearity present in the link considering the electrical parameters.
Rhabdomyosarcoma Surgical Update
Authors: Rogers Timothy , Schmidt Andreas , Buchanan Amanda F. , Scharschmidt Thomas , Dasgupta Roshni , Onwuka Ekene A. , Rodeberg David A. 
Published: January 2025

ABSTRACTRhabdomyosarcoma (RMS) tumors arise from mesenchymal tissue and represent half of pediatric sarcomas, which in turn make up 7% of pediatric tumors. Advances in local control therapy of RMS have improved outcomes after surgical resection of the primary tumor, either before or after induction chemotherapy, even in the setting of metastatic disease. The utilization of diagnostic core needle and sentinel node biopsy techniques for lymph node staging are becoming more widely used. Over the past several years, refinement of prognostic factors with adoption of fusion status instead of histology, and optimized risk stratification schemas have been developed to assure appropriate therapy. There have been efforts between North American and European surgical oncology cooperative groups to standardize the care we provide, and yet there are still some philosophical differences to overcome.
Visualizing the Spatial Distribution of Metabolites in Angelica sinensis Roots by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
Authors: Yue Xiaofei , Feng Li , Sun Chenglong , Wang Lu 
Published: January 2025

ABSTRACTIntroductionAngelica sinensis is one of the most popular traditional Chinese medicines (TCM) and has been extensively used to treat various diseases. Hundreds of endogenous ingredients have been isolated and identified from this herb, but their spatial distribution within the plant root is largely unknown.ObjectivesIn this study, we tried to investigate and map within‐tissue spatial distribution of metabolites in Angelica sinensis roots.Material and MethodsAfter optimization of experiment conditions, the 1,5‐diaminonaphthalene (1,5‐DAN) was chosen as the matrix and was sprayed on the surface of root sections. Then matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) was employed to perform in situ detection and obtain detail spatial distribution information of metabolites in Angelica sinensis roots.ResultsThe spatial distributions of a wide range of metabolites including organic acids, amino acids, oligosaccharides, and phospholipids were characterized and visualized in Angelica sinensis roots. Majority of these metabolites were located in the phloem and xylem, while ferulic acid was mainly present in the cork layer. The results revealed a dramatic metabolic heterogeneity among different regions of the roots and distinct spatial distribution patterns of different metabolites. Additionally, the metabolic pathways involved in the biosynthesis of choline were also successfully localized and visualized.ConclusionThis study comprehensively characterized the spatial distribution of metabolites in Angelica sinensis roots, which would prompt the understanding of its chemical separation, biosynthesis, and pharmacological activities.
Evaluating the impact of Keep Your Move in the Tube (KYMITT) on patient AM‐PAC scores and discharge disposition
Authors: Mattox Miriah , Ennis Julie , McClain Matthew , Trinidad Jennifer , Bajorek Alexander , Fonseca Tamela , West Katie , King Tonya , Lazensky Rebecca 
Published: January 2025

AbstractBackgroundThe Sarasota Memorial Health Care System (SMHCS) Acute Care Rehabilitation Team began implementing the Keep Your Move in the Tube (KYMITT) protocol in February 2023 to improve patient mobility and offer an alternative to traditional sternal precautions. The goal of KYMITT is for patients to remain within a safe zone (referred to as “the tube”) rather than complying with time and weight restrictions, which are the cornerstone of traditional sternal precautions. In previous studies, KYMITT was associated with greater independence after surgery without placing patients at an increased risk of experiencing a surgical site infection.ObjectiveTo test the hypothesis that KYMITT is associated with greater patient mobility and independence, without increasing the risk of surgical complications.MethodsResearchers at SMHCS analyzed records of 614 open‐heart surgery patients (n = 293 in the traditional sternal precautions group and n = 321 in the KYMITT protocol group) to determine the differences in their Activity Measure for Post‐Acute Care (AM‐PAC) mobility scores.ResultsThe average last‐recorded AM‐PAC score for the traditional sternal precautions group was significantly lower than for those receiving the KYMITT protocol (19.2 [95% CI: 18.86–19.62] vs. 20.0 [95% CI: 19.62–20.35], p = .006). For patients with at least two AM‐PAC scores recorded, the difference was calculated for each patient's first to last AM‐PAC score (AM‐PAC delta). There was not a statistically significant difference between groups with an average improvement of 2.7 (95% CI: 2.30–3.09) for the traditional sternal precautions group compared to 3.1 (95% CI: 2.71–3.45) for the KYMITT protocol, p = .16 when comparing average AM‐PAC delta.ConclusionOverall, during the 7 months that KYMITT was conducted hospital‐wide, a significant increase in average last‐recorded AM‐PAC scores was observed month to month (slope = 0.45, 95% CI: 0.27–0.62, p < .001).
Associations of aged neutrophils with disease activity in primary Sjögren's syndrome
Authors: Han Lei , Xiao Chunyuan , Lu Tianlin , Huang Xinfang 
Published: January 2025

AbstractBackgroundPrimary Sjögren's syndrome (pSS) is a chronic autoimmune disease that primarily affects exocrine glands. This study aimed to investigate the correlation between aged neutrophils and disease activity in patients with pSS.MethodsThis study included 21 patients diagnosed with pSS and 32 healthy controls (HCs) at Shanghai East Hospital between September 2021 and May 2023. Peripheral blood samples were collected from them. Neutrophil subsets were identified using cell surface markers (CD62L, CXCR4, CD11b, and CXCR1) and analyzed using flow cytometry. Clinical data, including the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) and serum ferritin levels, were also collected at admission.ResultsSerum ferritin levels were associated with the ESSDAI and neutrophil‐to‐lymphocyte ratio in patients with pSS. Our study revealed a significant increase in the frequency of aged neutrophils in patients with pSS compared to HCs (p < 0.05). The frequency of aged neutrophils significantly correlated with ESSDAI and ferritin levels in patients with pSS (p < 0.05). We generated a receiver operating characteristic (ROC) curve to evaluate the diagnostic utility of aged neutrophils in pSS. ROC analysis showed an area under the curve of 0.8036, with a p‐value of 0.0002.ConclusionsThis study confirmed that patients with pSS exhibit a higher percentage of aged neutrophils. Furthermore, aged neutrophils may serve as diagnostic markers of pSS.
Current Knowledge of Fetal Growth Restriction in Relation to Thrombosis at the Maternal‐Fetal Interface–Placenta and Umbilical Cord: A Literature Review
Authors: Zhang Yaxi , Shao Yong 
Published: January 2025

ABSTRACTBackgroundFetal growth restriction (FGR), defined as estimated fetal weight or abdominal circumference below the 10th percentile for gestational age, is a common complication of pregnancy. Placental malperfusion is the most common cause of FGR. Thrombosis at the maternal‐fetal interface (placenta and umbilical cord) is closely related to FGR. Failure of spiral artery remodeling in early pregnancy can lead to obstruction of uteroplacental blood flow, contributing to the development of FGR. Umbilical cord thrombosis is rare, with umbilical artery thrombosis being associated with more severe adverse pregnancy outcomes. Virchow's triad of thrombosis–blood stasis, hypercoagulability, and endothelial damage ‐ are risk factors for thrombosis at the maternal‐fetal interface.MethodsPubMed database was searched mainly using the terms ‘fetal growth restriction’ and “thrombosis”. Relevant articles retrieved were arranged to write this article.ResultsUmbilical cord abnormalities including intrinsic anatomical abnormalities, potential obstructive anatomical abnormalities, and transient anatomical abnormalities can cause placental thrombosis and fetal vascular malperfusion. Local hypercoagulability at the maternal‐fetal interface may be caused by physiological or pathological hypercoagulation in pregnant women, and abnormality in the placenta itself leading to a tendency for thrombosis is also getting recognized. Besides, vascular endothelial defects and immune reactions can cause damage to placental vascular endothelium, triggering local coagulation reactions.ConclusionThrombosis at the maternal‐fetal interface is a complex process. Further understanding of this process can deepen our knowledge of the pathophysiological mechanisms underlying FGR and provide guiding opinions to medical practice in treating and preventing FGR.Clinical Trial RegistrationThis study does not contain clinical trials.
The Impact of Social Investment and Green Finance on Sustainable Development: Evidence From Emerging Market Economies
Authors: Solangi Yasir Ahmed , Alyamani Rakan , Asghar Muhammad , Ali Sharafat , Magazzino Cosimo 
Published: January 2025

ABSTRACTThis study examines how social investment and green finance affect sustainable development (SDE) in 16 emerging market economies from 2014 to 2022. Truncated regression, Prais‐Winsten regression, and single‐equation instrumental variables (IV) regression models were applied for the empirical analysis. The findings reveal that social investment and green finance have positive effects, whereas poverty and ecological footprint negatively affect SDE. Social investment reduces the negative impact of poverty on SDE by enhancing human development and reducing economic vulnerability, confirming the moderation impact. The Juodis‐Karavias‐Sarafidis (JKS) panel's non‐causality analysis confirms the causal relationship between variables. This study recommends that emerging markets allocate more resources for social and green initiatives and limit their consumption of natural resources to avoid the negative consequences of a high ecological footprint. This study implies that doing and going green is essential for meeting sustainability challenges in the post‐modern era in emerging market economies.
Synthesis and Anticancer Activity of Benzimidazole and Benzothiazole Derivatives Bearing Furan Moiety by CAN as a Catalyst Under Ultrasonic Irradiation and Molecular Docking Studies
Authors: Mashhadi Elahe , Safaei‐Ghomi Javad , Yahya Misagh 
Published: January 2025

AbstractA practical method for the synthesis of 2‐(5‐arylfuran‐2‐yl)‐1H‐benzo[d]imidazole and 2‐(5‐arylfuran‐2‐yl)benzothiazole using cerium(IV) ammonium nitrate (CAN) as an inexpensive and readily available catalyst, under ultrasonic conditions is described. With the help of molecular docking studies, the anticancer properties of these compounds were studied and investigated for the first time. The docking study results revealed that the synthesized compounds significantly interacted with the target protein 5WS1. The synthesized compound 2‐(5‐(4‐chlorophenyl) furan‐2‐yl)‐5‐methyl‐1H‐benzo[d]imidazole achieved the highest docking score. Finally, the MTT assay was conducted on the best compound identified through molecular docking, revealing an IC50 value of 44.5 µg/mL. The results showed that the benzimidazole derivatives bearing furan are useful as a template for the future design of potent inhibitors against breast cancer cell lines (MCF7).