bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preferred atmospheric circulations associated with favorable prescribed burns in the Gulf of Mexico coast, USA
Authors: Kross Chelsea S. , Rohli Robert V. , Moon Jena A. , Fournier Auriel M. V. , Woodrey Mark S. , Nyman J. Andrew 
Published: February 2023

Abstract
Background
Application of prescribed fire in natural plant communities is an important wildlife habitat management tool. Prescribed fire managers have suggested anecdotally that changing weather patterns may be influencing the frequency of days that have optimal conditions to conduct coastal marsh burns along the US Gulf of Mexico coast. Our study objectives were to (1) determine whether the frequency of atmospheric circulation patterns associated with prescribed fire prescriptions has changed from 1979 to 2018 for the Gulf Coast and (2) identify circulation patterns preferred by land managers for implementing prescribed fire.

Results
While coastal marsh habitat is threatened by climate change and human-associated degradation, weather type frequency was not identified as an important factor related to the application of prescribed fire, as the frequency of weather circulation types has not changed significantly over time (p > 0.05). However, some weather circulation patterns seem more advantageous (e.g., offshore winds) or disadvantageous (e.g., wet cold fronts and high winds) for consideration by prescribed fire applicators across the Gulf.

Conclusions
Further insight into the weather conditions preferred and avoided by land managers along the Gulf of Mexico will improve prediction-based methods for identifying burn windows from weather forecasts. Land managers face many challenges in protecting coastal systems, while also reducing management conflicts (i.e., smoke transport) with local communities. Understanding how constraints such as urbanization, climate change, and sea-level rise interact to affect prescribed fire application will be an increasingly important aspect for developing successful adaptive management plans.
Fibrinogen level among children with liver cirrhosis
Authors: Hosseinabadi Samaneh Hamzelou , Honar Naser , Dehghani Seyed Mohsen , Javaherizadeh Hazhir 
Published: February 2023

Abstract
Introduction
The liver has a major role in the production of coagulation factors, and cirrhotic patients have a series of coagulopathy disorders. The present study aimed to measure plasma fibrinogen levels in children with hepatic cirrhosis.

Method
Patients younger than 18 years old after diagnosis of liver cirrhosis by biopsy were enrolled in the study. Laboratory data including hemoglobin, PT, PTT, INR, and liver function tests were recorded. Fibrinogen levels were measured using the Clauss method. PELD score for children less than 12 years and MELD Na for children over 12 years were used to measure the severity of the liver disease.

Results
Fifty children with cirrhosis were studied. The mean fibrinogen level in the “PELD < 15” group was significantly higher than the other group (P < 0.001). There was no significant relationship between bleeding and fibrinogen levels. There was no significant relationship between PELD and bleeding in subjects (P = 0.87). The results of the study showed neither of these two factors (fibrinogen level and PELD) can play a predictive role in causing hemorrhage in patients.

Conclusion
Our study has shown that fibrinogen level is significantly associated with severity of liver cirrhosis and decreases with more severe disease (PELD levels), but platelet and fibrinogen cannot predict the severity of bleeding in these patients.
Pediatric Neurosurgical Capacity for the Care of Children With CNS Tumors Worldwide: A Cross-Sectional Assessment
Authors: Roach Jordan T. , Qaddoumi Ibrahim , Baticulon Ronnie E. , Figaji Anthony , Campos Danny A. , Arredondo Luis , Boop Frederick A. , Moreira Daniel C. 
Published: February 2023

PURPOSE Efforts to address inequities in the treatment of pediatric CNS tumors and the burden of childhood cancer globally have prompted the designation of low-grade glioma as one of six index cancers for the World Health Organization Global Initiative for Childhood Cancer. Understanding the importance of neurosurgical interventions and evaluating pediatric neurosurgical capacity may identify critical interventions to improve outcomes for children with low-grade glioma and other CNS tumors. METHODS An online, cross-sectional survey assessing pediatric neurosurgical practice and capacity was distributed to members of the International Society of Pediatric Neurosurgery. The survey included 36 items covering domains including patient volume, available infrastructure, scope of practice, case distribution, and multidisciplinary care. RESULTS Responses from 196 individuals from 61 countries, spanning all WHO regions, were included. Ninety-six (49.0%) were from high-income countries, 57 (29.1%) were from upper-middle–income countries, 42 (21.4%) were from lower-middle–income countries (LMICs), and 1 was (0.5%) from a low-income country. Most respondents had a catchment population of ≥ 1 million and indicated the availability of basic neurosurgical resources such as a dedicated neurosurgical operating theater and surgical microscope. The presence of a neurosurgical intensive care unit, inpatient rehabilitation services, and infection monitoring showed similar availability across country groups. Quantitative scoring of 13 infrastructure and service items established that fewer resources were available in low-income countries/LMICs and upper-middle–income countries compared with high-income countries. The volume of pediatric CNS tumor cases and case distribution did not vary according to World Bank country groups. CONCLUSION This study provides a comprehensive evaluation of pediatric neurosurgical capacity across the globe, establishing variability of resources on the basis of the country income level. Our findings suggest that pediatric neurosurgeons in LMICs may benefit from key neurosurgical instrumentation and increased support for multidisciplinary brain tumor programs and childhood cancer research efforts.
Bortezomib-Dexamethasone, Rituximab, and Cyclophosphamide as First-Line Treatment for Waldenström's Macroglobulinemia: A Prospectively Randomized Trial of the European Consortium for Waldenström's Macroglobulinemia
Authors: Buske Christian , Dimopoulos Meletios A. , Grunenberg Alexander , Kastritis Efstathios , Tomowiak Cecile , Mahé Béatrice , Troussard Xavier , Hajek Roman , Viardot Andreas , Tournilhac Olivier , Aurran Therese , Lepretre Stephane , Zerazhi Hacene , Hivert Benedicte , Leblond Veronique , de Guibert Sophie , Brandefors Lena , Garcia-Sanz Ramon , Gomes da Silva Maria , Kimby Eva , Schmelzle Birgit , Kaszynski Dajana , Dreyhaupt Jens , Muche Rainer , Morel Pierre 
Published: February 2023

PURPOSE Rituximab/chemotherapy is a cornerstone of treatment for Waldenström's macroglobulinemia (WM). In addition, bortezomib has shown significant activity in WM. This study evaluated the efficacy and safety of dexamethasone, rituximab, and cyclophosphamide (DRC) as first-line treatment in WM. METHODS In this European study, treatment-naïve patients were randomly assigned to DRC or bortezomib-DRC B-DRC for six cycles. The primary end point was progression-free survival. Secondary end points included response rates, overall survival, and safety. RESULTS Two hundred four patients were registered. After a median follow-up of 27.5 months, the estimated 24-month progression-free survival was 80.6% (95% CI, 69.5 to 88.0) for B-DRC and 72.8% (95% CI, 61.3 to 81.3) for DRC ( P = .32). At the end of treatment, B-DRC and DRC induced major responses in 80.6% versus 69.9% and a complete response/very good partial response in 17.2% versus 9.6% of patients, respectively. The median time to first response was shorter for B-DRC with 3.0 (95% CI, 2.8 to 3.2) versus 5.5 (95% CI, 2.9 to 5.8) months for DRC. This resulted in higher major response rates (57.0% v 32.5%; P < .01) after three cycles of B-DRC compared with DRC. At best response, the complete response/very good partial response increased to 32.6% for B-DRC. Both treatments were well tolerated: grade ≥ 3 adverse events occurred in 49.2% of all patients (B-DRC, 49.5%; DRC, 49.0%). Peripheral sensory neuropathy grade 3 occurred in two patients treated with B-DRC and in none with DRC. CONCLUSION This large randomized study illustrates that B-DRC is highly effective and well tolerated in WM. The data demonstrate that fixed duration immunochemotherapy remains an important pillar in the clinical management of WM.
Impact of Frailty on Health Care Resource Utilization and Costs of Care in Myelodysplastic Syndromes
Authors: Mozessohn Lee , Li Qing , Liu Ning , Leber Brian , Khalaf Dina , Sabloff Mitchell , Christou Grace , Yee Karen , Chodirker Lisa , Parmentier Anne , Siddiqui Mohammed , Mamedov Alexandre , Zhang Liying , Liu Ying , Earle Craig C. , Cheung Matthew C. , Mittmann Nicole , Buckstein Rena 
Published: February 2023

PURPOSE: The role of frailty in affecting survival in myelodysplastic syndromes (MDS) is increasingly recognized. Despite this, a paucity of data exists on the association between frailty and other clinically meaningful outcomes including health care resource utilization and costs of care. METHODS: We linked the Ontario subset of the prospective Canadian MDS registry (including baseline patient/disease characteristics) to population-based health system administrative databases. Baseline frailty was calculated from the 15-item MDS-specific frailty scale (FS-15). Primary outcomes were public health care utilization and 30-day standardized costs of care (2019 Canadian dollars) determined for each phase of disease (initial, continuation, and terminal phases). Negative binomial regression was used to assess the association between frailty and health care costs with Poisson regression to explore predictors of hospitalization. RESULTS: Among 461 patients with complete FS-15 scores, 374 (81.1%) had a hospitalization with a mean length of stay of 10.6 days. Controlling for age, comorbidities, Revised International Prognostic Scoring System, and transfusion dependence, the FS-15 was independently associated with hospitalization during the initial ( P = .02) and continuation ( P = .01) phases but not the terminal disease phase ( P = .09). The mean 30-day standardized cost per patient was $8,499 (median, $6,295; interquartile range, $2,798-$11,996), largely driven by cancer clinic visits and hospitalization. On multivariable analysis, the FS-15 was independently associated with costs of care during the initial disease phase ( P = .02). CONCLUSION: We demonstrate an association between frailty and clinically meaningful outcomes including hospitalization and costs of care in patients with MDS. Our results suggest that baseline frailty may help to inform patients and physicians of expected outcomes.
Fetal Endoscopic Third Ventriculostomy Is Technically Feasible in Prenatally Induced Hydrocephalus Ovine Model
Authors: Peiro Jose L. , Duru Soner , Fernandez-Tome Blanca , Peiro Lucas , Encinas Jose L. , Sanchez-Margallo Francisco M. , Oria Marc 
Published: February 2023

BACKGROUND:
Congenital obstructive hydrocephalus generates progressive irreversible fetal brain damage by ventricular enlargement and incremental brain tissue compression that leads to maldevelopment and poor clinical outcomes. Intrauterine treatments such as ventriculo-amniotic shunting have been unsuccessfully tried in the eighties.

OBJECTIVE:
To assess if prenatal endoscopic third ventriculostomy (ETV) is feasible in a large animal model and optimize this technique for ventricular decompression and potential arrest of fetal brain damage in fetal lambs.

METHODS:
We generated hydrocephalus in 50 fetal lambs by injecting a polymeric agent into the cisterna magna at midgestation (E85). Subsequently, 3 weeks later (E105), fetal ETV was performed using a small rigid fetoscope. The endoscopy entry point was located anterior to the coronal suture, 7 mm from the midline.

RESULTS:
We obtained clear visualization of the enlarged lateral ventricles by endoscopy in the hydrocephalic fetal lambs. The floor of the third ventricle was bluntly perforated and passed with the scope for a successful ETV. Total success was achieved in 32/50 cases (64%). Causes of failure were blurred vision or third ventricle obliteration by BioGlue in 10/50 (20%) cases, anatomic misdirection of the endoscope in 5 (10%) cases, 2 cases of very narrow foramen of Monro, and 1 case of choroid plexus bleeding. If we exclude the cases artificially blocked by the polymer, we had a successful performance of prenatal-ETV in 80% (32/40) of hydrocephalic fetuses.

CONCLUSION:
Despite the inherent difficulties arising from ovine brain anatomy, this study shows that innovative fetal ETV is technically feasible in hydrocephalic fetal lambs.
Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development
Authors: McCoy Alyssa M. , Lakhdari Omar , Shome Sayane , Caoili Kaitlin , Hernandez Gilberto E. , Aghaeepour Nima , Butcher Lindsay D. , Fisch Kathleen , Prince Lawrence S. 
Published: February 2023

ABSTRACTMembers of the Sp family of transcription factors regulate gene expression via binding GC boxes within promoter regions. Unlike Sp1, which stimulates transcription, the closely related Sp3 can either repress or activate gene expression and is required for perinatal survival in mice. Here, we use RNA-seq and cellular phenotyping to show how Sp3 regulates murine fetal cell differentiation and proliferation. Homozygous Sp3−/− mice were smaller than wild-type and Sp+/− littermates, died soon after birth and had abnormal lung morphogenesis. RNA-seq of Sp3−/− fetal lung mesenchymal cells identified alterations in extracellular matrix production, developmental signaling pathways and myofibroblast/lipofibroblast differentiation. The lungs of Sp3−/− mice contained multiple structural defects, with abnormal endothelial cell morphology, lack of elastic fiber formation, and accumulation of lipid droplets within mesenchymal lipofibroblasts. Sp3−/− cells and mice also displayed cell cycle arrest, with accumulation in G0/G1 and reduced expression of numerous cell cycle regulators including Ccne1. These data detail the global impact of Sp3 on in vivo mouse gene expression and development.
Investigation of the Substitution Site Effect ono-Carborane-Based Chromophores by Anthracene Introduction at the B(3) Position
Authors: Ochi Junki , Tanaka Kazuo , Chujo Yoshiki 
Published: February 2023

Abstracto-Carborane-based emitters have been greatly developed over the last ten years. From the viewpoint of molecular symmetry, o-carborane has one type of equivalent carbon and four types of equivalent boron atoms. However, in contrast to the vast research of aryl-modified o-carboranes on the carbon atom of o-carborane, substitution on the boron atom is less investigated. Herein, we introduced an anthracene unit on the B(3) position of o-carborane and explored the substitution position effect by comparison with the previously reported C(1)-substituted regioisomer. Single-crystal structures, optical measurements, and quantum chemical calculation revealed the significant impact of the substitution position, especially in the intramolecular charge transfer (ICT) process.
Association of physical activity and heart rate variability in people with overweight and obesity: A systematic review
Authors: Kumar Sinha Mukesh , K. Vaishali , Maiya Arun G. , K.N. Shivashankar , U. Shashikiran , N. Ravi Shankar 
Published: February 2023

Background: Obesity is a major public health issue globally which is intrinsically linked to reduced heart rate variability (HRV). Physical inactivity and reduced resting HRV are linked to an increased risk of coronary heart disease, while athletes have a greater HRV. However, the exact correlation between physical activity and HRV remains uncertain. This systematic review aims to collect, report, and critically assess the current scientific literature about the association between physical activity and HRV in individuals with higher weight and obesity. Methods: A systematic search was carried out in electronic databases (Medline/PubMed, SCOPUS and CINAHL Plus) to retrieve studies that evaluated the relationship between physical activity and HRV in individuals with higher weight and obesity. Case-control, longitudinal/cohort, cross-sectional and observational studies were included. Using a critical narrative approach, information about the HRV, and physical activity was extracted and synthesized. The study was registered in PROSPERO: CRD42020208018 on October 9 2020. Results: After removing duplicates, 980 title/abstract records were checked for eligibility, and 12 papers were finally included in the narrative synthesis. The included studies contained physical activity as well as HRV in adults with higher weight or obesity with or without comorbidities. A negative relationship between moderate to vigorous physical activity and HRV indices had been found in two studies. There was also a negative relationship between sedentary time and HF (p = 0.049) and LF/HF (p = 0.036), as well as a positive relationship between sedentary time and LF (p = 0.014). Also dose-response association was found between vigorous exercise and higher SDNN, LF power, and HF power in one of the studies. Conclusions: This systematic review revealed a wide range of responses to physical activity and HRV; however, the current evidence uses a variety of approaches to objectively assess physical activity and measure HRV with different equipment.
Non-emergency medical transportation practice in Shanghai
Authors: Lu Weidong , Xu Wei , Shen Long 
Published: February 2023

Background: To describe the current landscape of non-emergency medical transportation (NEMT) services in China’s mainland, and analyze information obtained from a private NEMT company in Shanghai. Methods: With regards to the NEMT environment in China’s mainland, we collected relevant NEMT policies from the websites of local Health Commissions, and collected business operating data from a Chinese enterprise information query tool, Qichacha. With regards to NEMT service in Shanghai, we analyzed operating data from 3426 trips by a professional NEMT company. Descriptive statistics were used to explain the characteristics of NEMT trips, and log-linear analyses were performed to compare the trips inside Shanghai with trips to/from other areas. Results: Of the 3426 trips in this study, there were 2962 trips inside Shanghai (86.5%) and 464 trips to/from other areas (13.5%), and the number of trips to/from each province was related to the distance to Shanghai. When comparing transportation types between trips inside Shanghai and to/from other areas, there was a significant difference (χ2=144.87, p<0.001), with a significantly larger proportion of trips for discharge to/from other areas, and a significantly larger proportion of referrals in trips inside Shanghai. Over 50% of trips were to orthopedics-featured class A tertiary hospitals. Discussion and Conclusion: To lower the NEMT service costs and bring benefit to patients with a broader spectrum of diseases, medical insurance could completely or partially cover NEMT services, and companies could initiate rideshare services. Shanghai is an attractive place for patients, with the highest level of healthcare resources. Transportation combining high-speed trains and NEMT vehicles ensures patients who live further away can access health care in Shanghai.
Preparedness for contingencies: a systematic review of the factors that influence the crisis resilience of project managers
Authors: Kok Ching Wen , Shavarebi Kamran , Abu Talib Iffah Farhana Binti , Wider Walton , Nga Elsie 
Published: February 2023

Background: The goal of this review paper is to investigate factors that contribute to project managers' crisis resilience through a systematic review of the literature and bibliometric analysis using VOXviewer. Methods: Using the PRISMA framework for systematic literature, 55 peer-reviewed articles published between 1993 and 2022 that met our criteria were identified through a structured keyword search in the Scopus and WoS databases. Results: The systematic review and bibliometric analysis reveal eight clusters, which we further categorise into four determinants. In the context of the roles of project managers, the results of a comparative analysis reveal four prominent factors for enhancing crisis resilience: 1. leadership; 2. interpersonal skill; 3. agility; 4. risk management and vulnerability . These factors are essential for developing project managers who are less susceptible to future crises and disasters. This study has exhaustively characterised the possibilities and capacities of crisis resilience in terms of competency, integration, collaboration, and novelty; however, the search was restricted to a small number of databases and a short period of time, which could be explored in future research. Conclusions: According to the findings, most previous research on crisis resilience focused on emergency preparedness and was primarily conducted in Western and American studies. There is a lack of a holistic perspective on crisis resilience, which will be developed. We believe that international collaboration efforts to establish a platform for the exchange of knowledge between Western and American nations and ASEAN members are necessary.
Adjusting to Rain Before It Falls
Authors: Downey Mitch , Lind Nelson , Shrader Jeffrey G. 
Published: February 2023

Unchecked climate change will cause precipitation volatility to increase around the world, leading to economic damages in the face of adjustment costs. We estimate these damages for construction—an economically important, climate exposed industry. Empirically, employment falls in response to forecasted rainfall and more so as the forecast horizon increases. This pattern allows for identification of labor adjustment costs via a multisector model of local labor markets calibrated to our estimates. When rainfall is anticipatable one month ahead, construction firms pay 10% of monthly profit to adjust. They pay less than 1% for rainfall anticipatable six months ahead. Without further adaptation or forecast improvements, increased rainfall volatility due to climate change is projected to lead to more costly adjustment. This paper was accepted by Elke Weber, Special Section of Management Science on Business and Climate Change. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2023.4697 .
Inside-out and Outside-in Perspectives on Corporate Purpose
Authors: Almandoz Juan (“John”) 
Published: February 2023

Corporate purpose is receiving an extraordinary amount of attention from both scholars and practitioners. But do existing theories of management help us to understand this unexpected development? This study represents an effort to understand purpose better. I characterize inside-out and outside-in perspectives on purpose as distinct but connected phenomena related to different research traditions. Inside-out purpose is a channeling of the passion and commitment employees feel toward fulfilling stakeholder needs; outside-in purpose is society and external stakeholders urgently calling on the organization to live up to its responsibilities. I devote special attention to theories that best explain the present moment’s unique awareness of corporate purpose. Among them is the work of Philip Selznick, emphasizing values, and the literature on the new institutionalism and institutional logics. I conclude with a section on how leaders can leverage the benefits of both perspectives while mitigating their risks. I also make recommendations for future research.History: This paper has been accepted for the Strategy Science Special Issue on Corporate Purpose.Funding: This work benefited from funding from the Social Trends Institute and the Juan Antonio Perez Lopez Chair at IESE Business School.