bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detección precoz del cáncer de cuello uterino y sus determinantes: Un análisis de los resultados de los exámenes en una clínica universitaria de la ciudad de Pedro Juan Caballero, Paraguay
Authors: Chaves Pereira Henya , Soares de Souza Pedro Augusto , Klassen Grzechota Sandra , Dos Santos Guedes Gomes Stephania , Da Silva Arruda Yasmin , Fortaleza de Melo João Italo 
Published: March 2023

Este artículo presenta una investigación sobre el diagnóstico precoz del cáncer del cuello uterino (CCU) por medio del examen Papanicolau, abordando sus determinantes y factores en pacientes con características citopatológicas, que influyen para que el examen sea considerado como un instrumento sencillo y disponible a las mujeres de Pedro Juan Caballero, Paraguay. El CCU es una enfermedad causada por el papiloma humano virus (VPH) que afecta principalmente mujeres en edad reproductiva y es la segunda causa de cáncer en mujeres en Paraguay. Los VPH son un grupo de aproximadamente 200 virus, responsables por alrededor del 98% de los casos de CCU, donde cerca de 14 son considerados de alto riesgo. Histopatológicamente, el CCU se presenta por tumores de células escamosas, glandulares, mesenquimales o de células germinales, siendo que los primeros son reconocidos como lesiones precursoras o de estadio inicial. Este trabajo discute el cáncer de cuello uterino, su prevalencia y diagnóstico, a partir de un marco teórico basado en artículos científicos internacionales. La recolección de datos documentales se realizó a través de registros médicos de atención obtenidos en la Clínica Central de la Universidad Central del Paraguay. Este estudio retrospectivo es de corte transversal y analítico con un abordaje demográfico.
Palabras Clave: Cáncer, Diagnóstico Precoz, Papanicolau

Abstract
This article presents research on the early diagnosis of cervical cancer (CC) through the Pap test, addressing its determinants and factors in patients with cytopathological characteristics, which influence the examination to be considered as a simple instrument available to women in Pedro Juan Caballero, Paraguay. CC is a disease caused by the human papillomavirus (HPV) that mainly affects women of reproductive age and is the second cause of cancer in women in Paraguay. HPVs are a group of approximately 200 viruses, responsible for about 98% of CC cases, where about 14 are considered high risk. Histopathologically or logically, CC is presented by tumors of squamous, glandular, mesenchymal or germ cell tumors, the former being recognized as precursor lesions or from this to initial one. This paper discusses cervical cancer, its prevalence and diagnosis, from a theoretical framework based on international scientific articles. Documentary data were collected through medical records of care obtained at the Central Clinic of the Central University of Paraguay. This retrospective study is cross-sectional and analytical with a demographic approach.
Keywords: Cancer, Early Diagnosis, Pap Smear
Insuficiencia cardíaca en paciente chagásico: Reporte de caso
Authors: Oliveira Mota Bruno , Souza Bianca , Marciel Leidaiana , Queiroz Vitoria , Dos Santos Wesley José 
Published: March 2023

La enfermedad de Chagas es la causante de 12.000 muertes anuales como consecuencia de una miocardiopatía chagasica crónica que se presenta en un 20 a 30% de los infectados, con síntomas a partir de los 60 años del paciente, donde llega a presentar insuficiencia cardíaca. Es la tercera enfermedad parasitaria más prevalente, causada por Trypanosoma cruzi (T. cruzi), predominante en América Latina. El diagnóstico se basa en la epidemiología, imagen, hallazgos clínicos, cambios electrocardiográficos y pruebas de imagen asociadas a la serología. El objetivo del presente trabajo ha sido realizar un reporte de caso de un paciente que presentó insuficiencia cardíaca con enfermedad de Chagas. Los resultados demuestran la importancia de un diagnóstico oportuno de la enfermedad para no llegar a la etapa sintomática.
Palabras clave: Insuficiencia cardíaca, heridas, muerte.

Abstract
Chagas disease is the cause of 12,000 deaths annually because of chronic chagasic cardiomyopathy (CCC) that occurs in 20 to 30% of those infected, with symptoms after the age of 60, where it presents heart failure. It is the third most prevalent parasitic disease, caused by Trypanosoma cruzi (T. cruzi), which is predominant in Latin America. Diagnosis is based on epidemiology, clinical imaging findings, electrocardiographic changes, and imaging tests associated with serology. The objective of this paper was to present a case report of a patients who presented heart failure with Chagas disease. The results demonstrate the importance of a timely diagnosis of the disease in order not to reach the symptomatic stage.
Keywords: Heart failure, injuries, death.
Tabaquismo y el estudiante de Medicina: investigación sobre perfil y percepción de riesgo
Authors: Pereira da Silva Schiave Ana Lucia , Sande Rolon Valeria Yasmin 
Published: March 2023

El tabaquismo es considerado la principal causa de muerte evitable en el mundo. Entre los varios grupos de personas que hacen uso del tabaco se encuentran los jóvenes, pero ¿Cómo se puede determinar el tipo de tabaco consumido por los mismos? Este estudio transversal descriptivo tiene por objeto analizar el perfil del tabaquismo en los alumnos de la Universidad Central del Paraguay, Filial Pedro Juan Caballero. Se constata que la prevalencia en el consumo del tabaco se da en hombres jóvenes por medio del cigarrillo industrializado y electrónico, asociado a la búsqueda de disminuir la ansiedad. Se recomienda otros estudios acerca de la temática y el desarrollo de medidas educativas acerca de los daños causados por el uso del tabaco.
Palabras clave: Tabaquismo, ansiedad, estudiantes de medicina.​

AbstractTradução para Inglês.
Smoking is considered the leading cause of preventable death in the world. Among the various groups of people who use tobacco are young people, but how can you determine the type of tobacco consumed by them? This descriptive cross-sectional study aims to analyze the profile of smoking in students of the Central University of Paraguay, Pedro Juan Caballero Branch. It is found that the prevalence of tobacco consumption occurs in young men through industrialized and electronic cigarettes, associated with the search to reduce anxiety. Further studies on the subject and the development of educational measures on the harms caused by tobacco use are recommended.
Keywords: Smoking, anxiety, medical student
Consultoria colaborativa na Educação Infantil
Authors: Lima Adriana Sanches Sisto , Pereira Veronica Aparecida 
Published: March 2023

Nesse estudo descreve-se uma intervenção realizada junto à educação infantil na fase inicial da pandemia por COVID-19. Norteiam essa prática os princípios da Consultoria Colaborativa. Participaram do estudo 11 famílias, com filhos de até três anos, frequentadoras de um Centro de Convivência Infantil, em Dourados-MS. A Consultoria Colaborativa foi realizada à distância, por videochamada, em três etapas: 1) entrevistas com as mães; 2) orientação e planejamento; e 3) devolutiva e avaliação. As atividades foram norteadas a partir do protocolo do Inventário Portage Operacionalizado (IPO), contextualizadas no cotidiano das famílias, discutidas e planejadas individualmente. A comparação dos resultados antes e depois da intervenção indicou aumento das médias em todas as subáreas do protocolo de autocuidados, com diferenças significativas para vestuário (p=0,017), higiene (p=0,008) e índices totais (p=0,005). A Consultoria Colaborativa possibilitou a realização de atividades integradas à rotina familiar, podendo ser viável após a pandemia.
Droit des pauvres, pauvres droits : la Chambre de la jeunesse, au carrefour des inégalités et de la nouvelle gestion publique
Authors: Bernheim Emmanuelle 
Published: March 2023

Sous l’impulsion de la nouvelle gestion publique, la judiciarisation est en pleine augmentation à la Chambre de la jeunesse de la Cour du Québec. Cette judiciarisation est marquée par d’importantes inégalités, à l’intersection du genre, de la classe et de la race. L’accès aux droits et à la justice des parents et les conditions de la pratique en droit de la jeunesse sont pourtant peu documentés à ce jour.
À partir d’un terrain de recherche qualitatif, composé d’entrevues et d’observations, l’article qui suit présente, dans un premier temps, la concordance des expériences des avocates de la défense et des parents à la Chambre de la jeunesse ; dans un second temps, l’auteure discute de la judiciarisation comme amplificateur des inégalités sociales. La conclusion traite de la consistance de ces constats avec ceux qui viennent de recherches menées dans d’autres champs du droit social.
Synthesis, Characterization and Electrochemical Studies on the Corrosion Inhibition Properties of Schiff Bases for Mild Steel in 1 M HCl Solution
Authors: Ozoemena Chimezie P. , Boekom Ekerete Jackson , Akpan Inemesit, I. 
Published: March 2023

Schiff bases (SBL1 and SBL2), non-toxic compounds were synthesized, characterized and investigated as alternative anticorrosive additives for inhibition of mild steel corrosion in I M HCl acid medium. Corrosion of the steel was monitored by Potentiodynamic Polarization (PDP), Linear Polarization Resistance (LPR), Electrochemical Impedance Spectroscopy (EIS) and Weight Loss (WL) techniques. The novel Schiff base ligands obtained were characterized by Ultraviolet-visible and Fourier-Transform Infrared Spectroscopy. The elemental analysis data for the Schiff base ligands were used to confirm the formula of SBL1 as C17H20N2O2 and SBL2 as C24H21N5O2. Fourier-Transform Infrared spectroscopy suggest that the formation of a complex film on the mild steel surface was due to the adsorption of SBL1 and SBL2. The adsorption process was spontaneous and consistent with the mechanism of physical adsorption as best approximated by the Langmuir adsorption isotherm. Maximum inhibition efficiency was obtained at maximum concentration of 100 ppm for both SBL1 and SBL2 with SBL2 possessing the higher inhibition efficiency (86.21%) more than SBL1 (76.92%). Effectiveness of SBL1 and SBL2 reduced with increase in time and progressed with increase in concentration of SBL1 and SBL2. PDP measurements showed that SBL1 and SBL2 acted as a mixed type inhibitor. EIS measurement reveals that the corrosion process was controlled by charge transfer process. Values of the inhibition efficacy obtained from the different techniques were comparable. SEM micrographs of mild steel surface indicated good surface protection of SBL1 and SBL2.
Effect of Irrigation Scheduling and Foliar Organic Nutrition on Growth and Yield of Summer Groundnut (Arachis hypogaea L.)
Authors: Karthik Elukur , Singh Rajesh , Thakur Indu , Pradhan Akankhya 
Published: March 2023

A field experiment was conducted during summer season of 2022 at Crop Research Farm (CRF). Department of Agronomy, SHUATS, Prayagraj (UP) on soil with sandy loam in texture with Organic carbon 0.48%, Available Nitrogen 278.93 Kg/ha, Available Phosphorus 19.03 Kg/ha, Available Potassium 238.1 Kg/ha, Soil Ph 7.4, EC 0.47 ds/m to investigate the effect ofrrigation scheduling and foliar organic nutrition on growth and yield of Zaid Groundnut. The treatments consist of three irrigation schedulings viz., I1: 3 irrigations (25,45,70 DAS), I2: 2 irrigations (25,45 DAS), I3: 2 irrigations (25,70 DAS) and three foliar organic nutrition F1 – Panchagavya at 3%, F2 – Jeevamrutha at 3%, F3 – Panchamrutha at 3% whose effect is observed on Groundnut (var. Kadiri-6). The experiment was laid out in randomized block design with ten treatments replicated thrice. The treatment with application of 3 irrigations (25,45,70 DAS) + panchagavya-3% recorded significantly higher plant height (60.07cm) and plant dry weight (39.62 g), number of pods per plant (20.33), number of kernels per pod (2.47), seed index (39.84 g), pod yield (2.85 t/ha) and haulm yield (4.4 t/ha) compared to other treatment combinations. It is concluded that 3 irrigations (25,45,70 DAS) and panchagavya-3% accomplished better growth parameters, yield attributes and higher pod yield in groundnut crop.
Cross‐Cultural Pragmatics
Authors: House Juliane , Kádár Dániel Z. 
Published: March 2023

AbstractIn this entry, we provide an overview of the field of cross‐cultural pragmatics. We first summarize the historical development of the field. We then provide six Principles through which themodus operandiof cross‐cultural pragmatics can be best described. Finally, we provide examples of current research in the field.
Study Abroad as a Pedagogical Framework
Authors: Vidal Carmen Pérez 
Published: March 2023

Abstract
International mobility or study abroad (SA) consists of a formative stay in a country other than one's own in between periods of instruction at home. Pedagogical approaches to foster the potential benefits of SA periods are based on the assumption that the unique experience of living, studying, and integrating into a new community will result in linguistic, cultural, and personal development. When linguistic benefits are obtained, learners improve their listening abilities, become more fluent, and have greater and more diverse syntactic and lexical resources; particularly, if they also attend language courses abroad, are at an intermediate level, and have signed a language pledge. Culturally, it is also assumed that sojourners may develop as more autonomous learners and adopt a new outlook toward the target language culture and the world at large, with potentially positive effects on their future careers. However, research measuring the SA effects shows wide variability in results. Not all SA programs and settings offer the same opportunities, and not all individuals have the functional linguistic level and communication strategies to take advantage of the opportunities, features closely related to personality. For this reason, educational initiatives have been undertaken that seek to embed SA more firmly in the curriculum through pedagogic predeparture preparation, support during the stay, and debriefing upon return. SA these days takes place in multilingual settings where the new trend is toward the internationalization of education, with English as a Lingua Franca (ELF) being used as the medium of instruction on many courses (EMI).
Clinicoserological insights into patients with immune checkpoint inhibitor‐induced myasthenia gravis
Authors: Masi Gianvito , Pham Minh C. , Karatz Tabitha , Oh Sangwook , Payne Aimee S. , Nowak Richard J. , Howard James F. , Guptill Jeffrey T. , Juel Vern C. , O'Connor Kevin C. 
Published: March 2023

AbstractTo compare the immunopathology of immune checkpoint inhibitor‐induced myasthenia gravis (ICI‐MG) and idiopathic MG, we profiled the respective AChR autoantibody pathogenic properties. Of three ICI‐MG patients with AChR autoantibodies, only one showed complement activation and modulation/blocking potency, resembling idiopathic MG. In contrast, AChR autoantibody‐mediated effector functions were not detected in the other two patients, questioning the role of their AChR autoantibodies as key mediators of pathology. The contrasting properties of AChR autoantibodies in these cases challenge the accuracy of serological testing in establishing definite ICI‐MG diagnoses and underscore the importance of a thorough clinical assessment when evaluating ICI‐related adverse events.
Kinetics‐Controlled Synthesis of Ordered Mesoporous Carbon Single Crystals from Liquefied Wood
Authors: Wu Zhenwei , Zhang Kun , Sun Jiaming , Ma Chunhui , Luo Sha , Li Wei , Liu Shouxin 
Published: March 2023

AbstractThe architectures of carbon materials prepared via soft‐templating method greatly depend on the assembly pattern of micelles. Herein, a kinetics‐controlled strategy is developed to fabricate ordered mesoporous carbon (OMC) single crystals from liquefied wood by using melamine to regulate the polymerization rate of carbon precursors, which further affects the assembly process. Due to the slow hydroxymethylation reaction of melamine with formaldehyde in acid, the addition of melamine can decelerate the reaction kinetics to produce no seed nuclei at the initial stage, which favors the composite micelles to orderly aggregate and further grow in a layer‐by‐layer pattern to form OMC single crystals after carbonization. The OMC single crystals with high specific surface areas (733 m2 g−1), uniform mesopore size (3.2 nm), and ordered Im3m mesostructure are ideal supports to couple with Ag nanoparticles to act as efficient catalysts, which exhibits remarkable catalytic performance for the reduction of 4‐nitrophenol.
Single‐Source Vapor‐Deposition of MA1–xFAxPbI3 Perovskite Absorbers for Solar Cells
Authors: Soto‐Montero Tatiana , Kralj Suzana , Soltanpoor Wiria , Solomon Junia S. , Gómez Jennifer S. , Zanoni Kassio P. S. , Paliwal Abhyuday , Bolink Henk J. , Baeumer Christoph , Kentgens Arno P. M. , Morales‐Masis Monica 
Published: March 2023

AbstractVapor deposition of halide perovskites presents high potential for scalability and industrial processing of perovskite solar cells. It prevents the use of toxic solvents, allows thickness control, and yields conformal and uniform coating over large areas. However, the distinct volatility of the perovskite organic and inorganic components currently requires the use of multiple thermal sources or two‐step deposition to achieve the perovskite phase. In this work, single‐source, single‐step MA1–xFAxPbI3 thin film deposition with tunable stoichiometry by pulsed laser deposition is demostrated. By controlling the laser ablation of a solid target containing adjustable MAI:FAI:PbI2 ratios, the room temperature formation of cubic α‐phase MA1–xFAxPbI3 thin films is demonstrated. The target‐to‐film transfer of the ablated species, including the integrity of the organic molecules and the desired MA+:FA+ ratio, is confirmed by x‐ray photoelectron spectroscopy and solid‐state NMR. Photoluminescence analysis further confirms the shift of the bandgap with varying the MA+:FA+ ratio. Finally, proof‐of‐concept n‐i‐p solar cells with 14% efficiency are demonstrated with as‐deposited non‐passivated pulsed laser deposition (PLD)‐MA1–xFAxPbI3. This study opens the path for future developments in industry‐compatible vapor‐deposition methods for perovskite solar cells.
Enhancing Oral Performance of Paclitaxel Lipid‐Mimic Prodrug via Modulating Type of Fatty Acids
Authors: Miao Yi‐fan , Ye Qing , Zhang Ming‐yang , Gao Lin , Wang Xi‐yan , Zhong Wen‐xin , Wang Zi‐xuan , He Zhong‐gui , Tian Chu‐tong , Sun Jin 
Published: March 2023

AbstractOwing to the serious clinical side effects of intravenous Taxol, an oral chemotherapeutic strategy is expected to be promising for paclitaxel (PTX) delivery. However, its poor solubility and permeability, high first‐pass metabolism, and gastrointestinal toxicity need to be overcome. A triglyceride (TG)‐like prodrug strategy facilitates oral drug delivery by bypassing liver metabolism. However, the effect of fatty acids (FAs) in sn‐1,3 on the oral absorption of prodrugs remains unclear. Herein, a series of TG‐mimetic prodrugs of PTX is explored with different carbon chain lengths and degrees of unsaturation of FAs at the sn‐1,3 position in an attempt to enhance oral antitumor effect and to guide the design of TG‐like prodrugs. Interestingly, the different FA lengths exhibit great influence on in vitro intestinal digestion behavior, lymph transport efficiency, and up to fourfold differences in plasma pharmacokinetics. The prodrug with long‐chain FAs shows a more effective antitumor effect, whereas the degree of unsaturation has a negligible impact. The findings illustrate how FAs structures affect the oral delivery efficiency of TG‐like PTX prodrugs and thus provide a theoretical basis for their rational design.
Amorphous Copper‐Based Nanoparticles with Clusterization‐Triggered Phosphorescence for Ultrasensing 2,4,6‐Trinitrotoluene
Authors: Dai Zhuohua , Wang Guangfa , Xiao Fangfang , Lei Da , Dou Xincun 
Published: March 2023

AbstractAmorphous metal‐based nanostructures have attracted great attention recently due to their facilitative electron transfer and abundant reactive sites, whereas it remains enigmatic as to whether amorphous copper‐based nanoparticles (CuNPs) can be achieved. Here, for synthesizing amorphous CuNPs, glutathione is adopted as a ligand to inhibit the nucleation and crystallization process via its electrostatic repulsion. By subtly tailoring the solvent polarity, not only can amorphous glutathione‐functionalized CuNPs (GSH‐CuNPs) with phosphorescent performance be achieved after transferring the non‐conjugation of GSH ligand to through‐space conjugation, namely clusterization‐triggered emission, but also the phosphorescence‐off of GSH‐CuNPs toward 2,4,6‐trinitrotoluene (TNT) can be realized by the photoinduced electron‐transfer process through the hydrogen bond channel, which is established between carboxyl and amino groups of GSH‐CuNPs with the nitryl group of TNT. Benefitting from the intrinsic superiorities of the amorphous CuNPs, desired phosphorescence and detection performances of GSH‐CuNPs toward airborne TNT microparticulates are undoubtedly realized, including high quantum yield (13.22%), excellent specificity in 33 potential interferents, instantaneous response, and ultralow detection limit (1.56 pg). The present GSH‐CuNPs are expected to stretch amorphous metal‐based nanostructures and deepen the insights into amorphous materials for optical detection.
Photocatalytic Regio‐ and Site‐Selective Alkylamination of Coumarins: Access to 3‐Amino‐ and 4‐Amino Dihydrocoumarins
Authors: Jiang Yu‐Shi , Liang Feng , Chen Ai‐Min , Li Shan‐Shan , Luo Xue‐Ling , Xia Peng‐Ju 
Published: March 2023

AbstractFunctionalized dihydrocoumarins, including 3‐amino‐ and 4‐amino dihydrocoumarins serving as α‐ and β‐amino acid derivatives, have been synthesized using one‐step site‐ and regioselective alkylamination from coumarins. This conversion offers 35 examples in 24% to 81% yields.magnified image
Three‐Component Synthesis of 3‐(Arylsulfonyl)benzothiophenes Using Acetic Acid as a Quencher for Methyl Radical‐Mediated Side Reactions
Authors: Shridhar Bhat Vighneshwar , Lee Anna 
Published: March 2023

AbstractA one‐pot, three‐component synthesis of 3‐(arylsulfonyl)benzothiophenes was developed. The reaction did not require any catalysts or additives. The desired products were obtained via an intramolecular radical cyclization. Acetic acid was employed as the solvent and a quencher for side reactions involving methyl radicals. Moreover, inexpensive potassium metabisulfite was used as a sulfur dioxide surrogate. This process provides more opportunities for synthesizing benzothiophene derivatives, which are found in many bioactive compounds.magnified image