bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication-induced osteonecrosis of the jaw: a review of cases from the Food and Drug Administration Adverse Event Reporting System (FAERS)
Authors: Ahdi Hardeep S. , Wichelmann Thomas Adam , Pandravada Sasirekha , Ehrenpreis Eli D. 
Published: March 2023

Abstract
Background
Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug reaction (ADR) commonly associated with bisphosphonate and denosumab therapy. Prior research utilized an online, public FDA Adverse Event Reporting System (FAERS) Database to explore this ADR. This data identified and described several novel medications associated with ONJ. Our study aims to build upon the prior findings, reporting trends of medication induced ONJ over time and identifying newly described medications.

Methods
We searched the FAERS database for all reported cases of medication related osteonecrosis of the jaw (MRONJ) from 2010 to 2021. Cases lacking patient age or gender were excluded. Only adults (18 +) and reports from Healthcare Professions were included. Duplicate cases were removed. The top 20 medications were identified and described for April 2010-December 2014 and April 2015-January 2021.

Results
Nineteen thousand six hundred sixty-eight cases of ONJ were reported to the FAERS database from 2010–2021. 8,908 cases met inclusion criteria. 3,132 cases were from 2010–2014 and 5,776 cases from 2015–2021. Within the cases from 2010–2014, 64.7% were female and 35.3% were male, and the average age was 66.1 ± 11.1 years. Between 2015–2021, 64.3% were female and 35.7% were male, and the average age was 69.2 ± 11.5 years. Review of the 2010–2014 data identified several medications and drug classes associated with ONJ not previously described. They include lenalidomide, corticosteroids (prednisolone and dexamethasone), docetaxel and paclitaxel, letrozole, methotrexate, imatinib, and teriparatide. Novel drugs and classes described between 2015–2021 include palbociclib, pomalidomide, radium 223, nivolumab, and cabozantinib.

Discussion
While stricter inclusion criteria and removal of duplicate cases led to fewer overall identified cases of MRONJ when compared to prior research, our data represents a more reliable analysis of MRONJ reports to the FAERS database. Denosumab was the most frequently reported medication associated with ONJ. While unable to imply incidence rates from our data due to the nature of the FAERS database, our findings provide further description of the various medications associated with ONJ and elucidate patient demographics associated with the ADR. Additionally, our study identifies cases of several newly described drugs and drug classes that have not been previously described in literature.
Construction and recognition of acoustic ID of ancient coins based on deep learning of artificial intelligence for audio signals
Authors: Jin Xiaoxue , Wang Xiufeng , Cao Xinqiang , Xue Chaohua 
Published: March 2023

Abstract
In the field of cultural heritage protection, it is significant to establish a reliable ID (identifier) for valuable cultural and artistic items. At present, the identification of ancient cultural relics is mainly based on image information, such as pictures, 3D (three-dimensional) scanning, X-ray and CT (computed tomography) data. However, in many cases, it is impossible to identify whether slight damage, partial restorations, or ancient cultural relics have been replaced by fakes by using image information. In the era of digital duplication, more reliable identity information is urgently needed. The main technical challenge of an acoustic analysis system for ancient coins based on artificial intelligence technology is to find a non-destructive, fast and accurate identification method for ancient cultural relics. The recognition method includes two main modules: the artificial audio data sampling device and deep learning. In addition, this paper has completed the analysis of the vibration spectrum features of 19 ancient coins and realized the whole process of acoustic ID construction. The open-source platform Easy DL was used to analyze the multidimensional vibration spectrum curve feature extraction and identification. This method enables audio signal signature recognition technology to be applied in the display, preservation, transaction and safety management of ancient coins and other cultural relics.
Benefits of high-dielectric pad for neuroimaging study in 7-Tesla MRI
Authors: Park Shin-Eui , Jeon Yeong-Jae , Baek Hyeon-Man 
Published: March 2023

AbstractThis study aimed to evaluate whether the use of a high-dielectric pad is effective in increasing transmit and receive sensitivity in areas of low signal intensity in the human brain at high magnetic fields and assess its usefulness in neuroimaging studies. The novelty of this study lies in the first reported use of diffusion tensor imaging (DTI) results to evaluate the effect of the pad on neuroimaging. Six volunteers underwent MR scanning using a 7 T MR system. T1-weighted images (T1w) and diffusion-weighted images (DWI) were acquired to demonstrate the benefits of a high-dielectric pad made of barium titanate (BaTiO3). For all imaging experiments, two datasets were acquired per person, one with and one without a high-dielectric pad. Enhancement of signal sensitivity in neuroimaging has been analyzed by DTI study. Higher signal intensities and spatial contrast were demonstrated in the in T1w images acquired using high-dielectric pad than in those acquired without high-dielectric pad. Especially in DTI studies, increased quantitative anisotropy (QA) signals were observed in the corticospinal tract (CST), frontopontine tract (FPT), splenium of corpus callosum (SCC), fornix (FX), inferior fronto-occipital fasciculus (IFOF), cerebellum (CB), middle cerebellar peduncle (MCP), and body of corpus callosum (BCC) (FDR < 0.05). The signal differences accounted for an overall 20% increase. A high-dielectric pad is effective in enhancing signal intensity in human brain images acquired using 7 T MRI. Our results show that the use of such pad can increase the spatial resolution, tissue contrast, and signal intensity in neuroimaging studies. These findings suggest that high-dielectric pads may provide a relatively simple and low-cost method for spatiotemporal brain imaging studies.
Changes in nutrient stoichiometry in responding to diatom growth in cyclonic eddies
Authors: Zhou Kuanbo , Xu Yanping , Kao Shuh-Ji , Xiu Peng , Wan Xianhui , Huang Bangqin , Liu Xin , Du Chuanjun , Sun Jun , Sun Zhenyu , Dai Minhan 
Published: March 2023

AbstractNutrient stoichiometry (e.g., nitrate + nitrite to soluble reactive phosphorus, refer to N + N/SRP, N/P hereafter) governs growth, competition and niche partitioning of phytoplankton in the illuminated oceans. The N/P, however, varies widely across the ocean and the underlying mechanisms remain unclear. Here, we report direct observations of significant variations in N/P in response to different life stages of two cyclonic eddies observed in the western South China Sea. High N/P (19.1 ± 6.9) values were observed around the nitracline in a mature-stage eddy, whereas a decay-stage eddy was characterized with low N/P (14.4 ± 4.1). The elevated N/P ratios accompanied by enriched fucoxanthin (pigment for diatom) and biogenic silica around the nitracline suggest that eddy pumping enhanced the growth of diatom which preferentially uptakes P relative to N in the mature stage of the eddy. Such high N/P ratios in the upper ocean could be reproduced if diatom uptake ratio was set between 10 and 16 in a data constrained numerical model. The preferential P uptake by enhanced diatom growth might reduce the P supply to the surface ocean, which is critical for N2-fixers. The transient changes in nutrient stoichiometry associated within the life cycle of cyclonic eddies also challenges the parameterization of physical–biogeochemical models with fixed phytoplankton uptake stoichiometry ratios, which could lead to bias of the model output for phytoplankton dynamics in oligotrophic ocean, where eddies frequently occur.
Enhancing biological control: conservation of alternative hosts of natural enemies
Authors: Cortez-Madrigal Hipolito , Gutiérrez-Cárdenas Oscar Giovanni 
Published: March 2023

Abstract
Background
There is a consensus that the conservation of natural enemies is the most important biological control strategy, but it has also been the least attended. The reason is simple: there is a strong contradiction between modern agriculture and biological control. Various strategies have been proposed for the conservation of natural enemies, among others, protection against pesticides and establishment of nectar plants as alternative food. Less attention has been paid to the conservation of alternative hosts for natural enemies.

Main body
Natural enemies are not exclusive to pests, on the contrary, numerous species require alternative prey and hosts for their prevalence. Their conservation is a strategy widely referenced in scientific literature; however, this idea is not consistent with the studies developed. From 1973 to 2021, only 21 studies that emphasized the use of alternative hosts were recorded. Most focused on single phytophagous–natural enemy species, and little attention was given to the plant–phytophagous relationship. For example, Asclepias curassavica (Apocynaceae) hosts more than nine species of specialist phytophagous; and they, in turn, attracted 24 species of natural enemies. Although different studies demonstrate the potential of alternative hosts, some presume an adverse or doubtful effect on pest control; for example, additional vegetation in agroecosystems could act as a source, but also as a sink for natural enemies. This analysis tries to fit biological control to the modern agricultural paradigm, and not the other way around, as suggested by ecological theory. We support the idea that conservation biological control should be directed toward the conservation of multiple species, with the aim of controlling not only pest, but also the self-regulation of the agroecosystem. The path that should be followed by the study and application of alternative hosts as a strategy of biological control by conservation is discussed.

Conclusion
The wide diversity of non-pest insect species suggests an enormous potential for their exploitation as alternative hosts. The evaluation of host plants of specialized phytophagous species could improve biological control and reduce the risk of pests for crops. This strategy would partly fill the huge gap that exists in modern agroecosystems in terms of biological diversity.
Acute herpetic encephalitis with atypical radiological presentation
Authors: Singh Mridula , Khandelwal Dinesh , Mathur Vaibhav , Shah Chandani 
Published: March 2023

AbstractA 39-year-old male without any preceding medical ailment presented with 12 day history of fever followed by behavioral changes with left sided weakness. He was found to have Herpes Simplex Virus-1 encephalitis (polymerase chain reaction positive) and with Magnetic Resonance Imaging finding of asymmetrical frontotemporoparietal (right side affected more than left side) involvement with patchy enhancement with atypical nodular enhancement and subtle diffusion restriction. Nodular enhancement is rare in acute inflammations and is reported mainly with chronic granulomatous infections.
Robotic versus open partial nephrectomy in the context of mild severity complications: a meta-analysis of comparative studies supplemented by meta-regression
Authors: Artsitas Sotirios , Artsitas Dimitrios , Segkou Ioanna , Koronaki Irene , Toutouzas Konstantinos G. , Zografos George C. 
Published: March 2023

Abstract
Background
The incidence of mild postoperative complications has been shown to be strongly associated with the beneficial effects provided through minimally invasive surgery. The main objective of the present study was to compare robotic and conventional open partial nephrectomy in terms of the incidence of mild postoperative complications.

Main body
The literature search process included all the comparative studies identified up to April 2022. Inclusion criteria concerned studies published in English, involving exclusively adult patients with solitary or multiple renal masses, who underwent robotic/robot-assisted or open partial nephrectomy. As mild postoperative complications, were defined those of Clavien–Dindo grade ≤ II. The meta-analysis included a total of 16 studies (3238 patients) and was also supplemented by appropriate subgroup analysis and meta-regression analysis to investigate for any additional sources of heterogeneity. Pooled data analysis revealed a statistically significant advantage with the adoption of the robotic approach (petoOR = 0.52, CI95% [0.43; 0.64]), while similar results were obtained from the analysis of the subgroups of studies with or without patient matching, those conducted in a single or multiple centers, as well as those published after 2015. From meta-regression, a time-independent superiority of robotic over open partial nephrectomy emerged, characterized by a tendency to broaden over the years. This finding was attributed to inherent features of robotic technology, the utilization of which is optimized in the context of its wider adoption in current kidney surgery practice.

Short conclusion
The main conclusion that can be drawn implies the clear superiority on the part of robotic partial nephrectomy over open surgery, in reducing the incidence of mild postoperative complications.
Trophic level and proteobacteria abundance drive antibiotic resistance levels in fish from coastal New England
Authors: Korry Benjamin J. , Belenky Peter 
Published: March 2023

Abstract
Background
The natural marine environment represents a vast reservoir of antimicrobial resistant bacteria. The wildlife that inhabits this environment plays an important role as the host to these bacteria and in the dissemination of resistance. The relationship between host diet, phylogeny, and trophic level and the microbiome/resistome in marine fish is not fully understood. To further explore this relationship, we utilize shotgun metagenomic sequencing to define the gastrointestinal tract microbiomes of seven different marine vertebrates collected in coastal New England waters.

Results
We identify inter and intraspecies differences in the gut microbiota of these wild marine fish populations. Furthermore, we find an association between antibiotic resistance genes and host dietary guild, which suggests that higher trophic level organisms have a greater abundance of resistance genes. Additionally, we demonstrate that antibiotic resistance gene burden is positively correlated with Proteobacteria abundance in the microbiome. Lastly, we identify dietary signatures within the gut of these fish and find evidence of possible dietary selection for bacteria with specific carbohydrate utilization potential.

Conclusions
This work establishes a link between host lifestyle/dietary guild, and microbiome composition and the abundance of antibiotic resistance genes within the gastrointestinal tract of marine organisms. We expand the current understanding of marine organism-associated microbial communities and their role as reservoirs of antimicrobial resistance genes.
Impact of changing PI-RADS cutoff on prostate cancer detection by MRI cognitive fusion biopsy in biopsy-naïve patients
Authors: El-Helaly Hesham Abdel-Azim , Mahmoud Asem Abdel-Aziz , Magdy Ahmed Mohamed , Hasehem Abdelwahab , Ibrahim Hamdy Mohamed , Mohamed Khaled Moheyelden , Ismail Mohamed Hamdy 
Published: March 2023

Abstract
Background
Multi-parametric magnetic resonance imaging may improve the detection of prostate cancer. The aim of this work is to compare between PI-RADS 3–5 and PI-RADS 4–5 as a threshold for targeted prostatic biopsy.

Methods
This is a prospective clinical study that included 40 biopsy-naïve patients referred for prostate biopsy. Patients underwent prebiopsy multi-parametric (mp-MRI), followed by 12-core transrectal ultrasound-guided systematic biopsy and cognitive MRI/TRUS fusion targeted biopsy from each detected lesion. The primary endpoint was to assess the diagnostic accuracy of the PI-RAD 3–4 versus PI-RADS 4–5 lesion by mpMRI for prostate cancer detection in biopsy-naive men.

Results
The overall prostate cancer detection rate and the clinically significant cancer detection rate were 42.5% and 35%, respectively. Targeted biopsies from PI-RADS 3–5 lesions showed a sensitivity of 100%, specificity of 44%, positive predictive value of 51.7%, and negative predictive value of 100%. Restricting targeted biopsies to PI-RADS 4–5 lesions resulted in a decrease in sensitivity and negative predictive value to 73.3% and 86.2%, respectively, while specificity and positive predictive value were increased to 100% for both parameters which was statistically significant (P value < 0.0001 and P value = 0.004, respectively).

Conclusions
Limiting the TBs to PI-RADS 4–5 lesions improves the performance of mp-MRI in the detection of prostate cancer especially aggressive tumors.
The value of adding DWI and FLAIR signal changes in the resection cavity on the diagnostic performance of BT-RADS category 3 for tumor progression prediction in post-treated glioma patients: a prospective pilot study
Authors: Metwally Maha Ibrahim , Hafez Faten Fawzy Mohammad , Ibrahim Sara Abdulrhman , Morsy Ahmed Ali , Zeed Nesma Adel 
Published: March 2023

Abstract
Background
BT-RADS is a structured reporting system of post-treatment glioma. BT-RADS category 3 carries a probability of recurrent malignancy versus treatment-related changes. The aim of this study is to evaluate the additive value of DWI and resection cavity FLAIR signal changes to BT-RADS category 3 in the prediction of tumor progression. We prospectively evaluated follow-up contrast-enhanced MR imaging where 27 post-treated glioma patients were assigned BT-RADS category 3. In all images, FLAIR signal, enhancement component, mass effect, and ADCmean were assessed. We used imaging follow-up from the second stage of the study as the gold standard for comparing the diagnostic performance of BT-RADS category 3 for predicting tumor recurrence before and after the addition of DWI and resection cavity FLAIR signal changes. ROC curves analyses were assessed and compared using the Delong test.

Results
48.1% of patients had tumor recurrence and 51.9% of patients had treatment-related changes. There was significant difference between ADCmean in recurrent and non-recurrent groups measuring 0.9 and 1.15 × 10−3mm2/s, respectively (p value < 0.001). BT-RADS, BT-RADS added DWI, and BT-RADS added DWI and resection cavity FLAIR signal had a specificity of 64.3, 71.4, and 71.4%, sensitivity of 76.9, 84.6, and 92.3%, and accuracy of 70.5, 77.8, and 81.5%, with improved AUC from 0.706 (95% CI of 0.50–0.86) to 0.78 (95% CI of 0.58–0.92) to 0.819 (95% CI of 0.64–0.94), respectively.

Conclusions
Adding DWI and resection cavity FLAIR signal alteration improves the diagnostic performance of BT-RADS category 3.
Prescribing patterns of thromboprophylaxis post-bariatric surgeries: no additional benefits of extended prophylaxis
Authors: Almalki Abdullah S. , Al Recheq Heba Adel , Bajnaid Eshtyage , Boraii Sherif , Abdelaziz Doaa H. , El Hadidi Seif 
Published: March 2023

Abstract
Background
Venous thromboembolism is one of the critical complications of bariatric surgeries resulting in life-threatening outcomes. The benefits and duration of appropriate thromboprophylaxis in the morbidly obese patients stay unclear. The study aims to compare the benefits of in-hospital thromboprophylaxis versus extended thromboprophylaxis post-bariatric surgery among a cohort with a high prevalence of morbid obesity.

Results
A retrospective observational cohort study was conducted on 229 morbidly obese patients who had undergone bariatric surgery in a tertiary care teaching hospital in Saudi Arabia. Upon discharge, the patients were split either to receive no thromboprophylaxis or enoxaparin 40 mg once or twice daily for 14–21 days post-discharge. Primary outcomes were the clinical difference between the study groups in the percentage of patients who developed a symptomatic venous thromboembolic event during postoperative hospitalization or after discharge. Among patients who received no thromboprophylaxis (n = 119), no one developed a venous thromboembolic event, while, in the extended prophylaxis group (n = 110), 1.82% developed a non-fatal one (P = 0.23). Additionally, no significant difference in percentages of bleeding events occurred in both groups (p = 0.054).

Conclusions
The incidence of venous thromboembolism and bleeding events that occurred with extended thromboprophylaxis were deemed comparable and non-significant to the conventional in-hospital thromboprophylaxis. However, portal thrombosis stays an enigmatic complication despite its documented sparsity in literature.
Destruction of Anderson localization by subquadratic nonlinearity
Authors: Milovanov A. V. , Iomin A. 
Published: March 2023

Abstract
It is shown based on a mapping procedure onto a Cayley tree that a subquadratic nonlinearity destroys Anderson localization of waves in nonlinear Schrödinger lattices with randomness, if the exponent of the nonlinearity satisfies

, giving rise to unlimited subdiffusive spreading of an initially localized wave packet along the lattice. The focus on subquadratic nonlinearity is intended to amend and generalize the special case s = 1, considered previously, by offering a more comprehensive picture of dynamics. A transport model characterizing the spreading process is obtained in terms of a bifractional diffusion equation involving both long-time trappings of unstable modes on finite clusters and their long-haul jumps in wave number space consistent with Lévy flights. The origin of the flights is associated with self-intersections of the higher-order Cayley trees with odd coordination numbers z > 3 leading to degenerate states.
Impact of economic growth on scientific production in Latin America and the Caribbean based on panel data analysis
Authors: Rivera-Lozada Oriana , Yangali-Vicente Judith Soledad , Millones-Gòmez Pablo Alejandro , Minchón -Medina Carlos Alberto , Rosales-Cifuentes Tania Valentina 
Published: March 2023

Background: The great difference in scientific production among countries, especially in Latin America and the Caribbean, may be related to the economic growth of each nation, but countries with larger economies do not necessarily have higher scientific production. Political changes and unstable economies result in little sustainability of scientific production in the countries in these regions. The purpose of this study was to determine the impact of economic growth on scientific production, measured as the variation in the gross domestic product and the number of scientific publications, in Latin American and Caribbean countries. Methods: The analyzed information was collected from the open data source of the World Bank for the years from 2000 to 2018. The analysis was performed using unbalanced data panel models that cross-sectionally considered the countries of Latin America and the Caribbean and longitudinally considered the period 2000-2018 using grouped regression models, fixed effects models or random effects models. The Hausman test was used to choose between fixed and random effects models. Results: The results of both the random effects models and the fixed effects models demonstrated the negative impact of economic growth on scientific production. This proves that it is necessary to state alternatives to mend and improve the state of scientific production. Conclusion: The present study is relevant because it is one of the first to study the impact of gross domestic product on scientific production in Latin American and Caribbean countries from a longitudinal perspective that also allows evaluating the dynamics of both variables.