bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trend in tropopause warming and its influence aircraft performance
Authors: Cizrelioğullari Mehmet Necati , Imanov Tapdig Veyran , Gunay Tugrul , Shaiq Amir Aliyev 
Published: February 2023

Purpose
Temperature anomalies in the upper troposphere have become a reality as a result of global warming, which has a noticeable impact on aircraft performance. The purpose of this study is to investigate the total air temperature (TAT) anomaly observed during the cruise level and its impact on engine parameter variations.

Design/methodology/approach
Empirical methodology is used in this study, and it is based on measurements and observations of anomalous phenomena on the tropopause. The primary data were taken from the Boeing 747-8F's enhanced flight data recorder, which refers to the quantitative method, while the qualitative method is based on a literature review and interviews. The GEnx Integrated Vehicle Health Management system was used for the study's evaluation of engine performance to support the complete range of operational priorities throughout the entire engine lifecycle.

Findings
The study's findings indicate that TAT and SAT anomalies, which occur between 270- and 320-feet flight level, have a substantial impact on aircraft performance at cruise altitude and, as a result, on engine parameters, specifically an increase in fuel consumption and engine exhaust gas temperature values. The TAT and Ram Rise anomalies were the focus of the atmospheric deviations, which were assessed as major departures from the International Civil Aviation Organizations–defined International Standard Atmosphere, which is obvious on a positive tendency and so goes against the norms.

Research limitations/implications
Necessary fixed flight parameters gathered from the aircraft's enhanced airborne flight recorder (EAFR) via Aeronautical Radio Incorporated (ARINC) 664 Part 7 at a certain velocity and altitude interfacing with the diagnostic program direct parameter display (DPD), allow for analysis of aircraft performance in a real-time frame. Thus, processed data transmits to the ground maintenance infrastructure for future evaluation and for proper maintenance solutions.

Originality/value
A real-time analysis of aircraft performance is possible using the diagnostic program DPD in conjunction with necessary fixed flight parameters obtained from the aircraft's EAFR via ARINC 664 Part 7 at a specific speed and altitude. Thus, processed data is transmitted to the ground infrastructure for maintenance to be evaluated in the future and to find the best maintenance fixes.
Routine failure in Macedonia: a critique of the Global Financial Crisis from the periphery
Authors: Mattioli Fabio 
Published: February 2023

AbstractIn most Western analyses, the Global Financial Crisis (GFC) constituted a systemic failure that spread across the entire capitalist system from the United States. That was not, however, the discourse that circulated in (and about) Macedonia – a peripheral country that had been mired in economic disasters since its transition from socialism. Local experts and citizens believed that Macedonia hadnotbeen severely impacted by the GFC. This essay asks how economic crises and their aftermaths are experienced and evaluated when they are effectively routine or ‘normal’. Overall, it argues that, in a landscape punctuated by continual disruption, the GFC appeared not as a failure, but as a new reconfiguration of power that strengthened the position of new elites through increasingly oppressive relations of (inter)dependence.
Endocrine modulating chemicals in food packaging: A review of phthalates and bisphenols
Authors: Tumu Khairun , Vorst Keith , Curtzwiler Greg 
Published: February 2023

AbstractPhthalates and bisphenol chemicals have been widely used globally in packaging materials and consumer products for several decades. These highly functional chemicals have become a concern due to their toxicity (i.e., endocrine/hormone modulators) and ability to migrate from food contact materials (FCMs) into food matrices and the environment resulting in human and environmental health risks. FCMs, composed of postconsumer materials, are particularly high risk for containing these compounds. The evaluation of postconsumer recycled feedstocks in FCMs is compulsory and selection of an appropriate detection method to comply with applicable regulations is necessary to evaluate human and environmental safety. Numerous regulations have been proposed and passed globally for both compound classes that are recognized as priority pollutants by the United States Environmental Protection Agency and the European Union. Several brand owners and retailers have also released their own “restricted substance lists” due to the mounting consumer and regulatory concerns. This review article has two goals: (1) discuss the utilization, toxicology, human exposure routes, and occurrence levels of phthalates and bisphenols in FCMs and associated legislation in various countries and (2) discuss critical understanding and updates for detection/quantification techniques. Current techniques discussed include extraction and sample preparation methods (solid‐phase microextraction [SPME], headspace SPME, Soxhlet procedure, ultrasound‐assisted extraction), chromatographic techniques (gas, liquid, detectors), and environmental/blank considerations for quantification. This review complements a previous review of phthalates in foods from 2009 by discussing phthalate and bisphenol characteristics, analytical methods of determining concentrations in packaging materials, and their influence on the migration potential into food.
Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin and its metabolite ciprofloxacin, and sulfachloropyridazine‐trimethoprim in Taihe black‐boned silky fowls
Authors: Yuan Lijuan , Wu Huizhen , Wang Jianmei , Zhou Min , Zhang Li , Xiang Jianjun , Liao Qiegen , Luo Linguang , Qian Mingrong , Zhang Dawen 
Published: February 2023

AbstractEnrofloxacin (ENR) and sulfachloropyridazine combined with trimethoprim (TMP) were commonly used in poultries to treat bacterial infections. In this study, the pharmacokinetics of these antibiotics in four tissues of Taihe black‐boned silky fowls was studied. The results showed that these drugs were absorbed and distributed rapidly, with the highest concentration showing in skin. Meanwhile, ENR and its metabolite ciprofloxacin (CIP) and TMP were depleted slowly, particularly in skin with the elimination half‐lives being 37.1, 36.9, and 72.7 days, respectively. It may be attributed to the abundance of melanin in skin. The dietary risk assessment suggested that the long‐term dietary intakes of ENR, CIP, and TMP showed a considerable threat to human health. Based on the experiment, the withdrawal times of 284 days for ENR + CIP and 159 days for TMP were acquired, which showed that these drugs are not appropriate for the application in Taihe black‐boned silky fowls.
The migration and loss of water in emulsified surimi gels prepared with different phase states of lipids: Effect of freeze‐thawing treatments
Authors: Liu Cikun , Feng Ruonan , Li Jun , Hu Zhongliang , Xu Yanshun , Xia Wenshui , Jiang Qixing 
Published: February 2023

AbstractThe freeze‐thawing (FT) stability generally correlates well with the economic value and acceptability of frozen surimi‐based products. However, quality changes of emulsified surimi gels under FT conditions are still unclear. Therefore, the gel properties of samples with different phase states of lipids (lard, lard + soybean oil, and soybean oil) were investigated at FT conditions. Results showed that the soybean oil evidently improved the rheological behaviors of sols/gels compared to the lard group. The moisture content of samples with different lipids decreased by 2.40%–2.71% after 4 FT cycles. With increasing FT cycles, the water‐holding capacity decreased accompanied by the increase of cooking loss. Spin–spin relaxation spectra and hydrogen proton density images proved the occurrence of water migration of gels during these processes. Better gel integrity was observed in samples consisting of soybean oil, where the proportion of pores was lower than those with lard regardless of FT treatments. Additionally, the intermolecular forces of gels also changed under FT treatments. There results suggested that the lipids with different phase states affected the migration and loss of water in emulsified surimi gels under FT cycles.Practical ApplicationThe quality changes of heating‐induced surimi gel products under frozen storage have been ignored, especially the emulsified surimi gels. This study discloses the changes of the gel properties in emulsified gel products with different phase states of lipids after FT treatments, which provides critical insights into the quality improvement of this novel emulsified surimi product during processing, storage, and transportation.
Chromosome‐level genome assembly of a triploid poplar Populus alba ‘Berolinensis’
Authors: Chen Song , Yu Yue , Wang Xinyu , Wang Sui , Zhang Tianjiao , Zhou Yan , He Ruihan , Meng Nan , Wang Yiran , Liu Wenxuan , Liu Zhijie , Liu Jinwen , Guo Qiwen , Huang Haijiao , Sederoff Ronald R. , Wang Guohua , Qu Guanzheng , Chen Su 
Published: February 2023

AbstractMany recent studies have provided significant insights into polyploid breeding, but limited research has been carried out on trees. The genomic information needed to understand growth and response to abiotic stress in polyploidy trees is largely unknown, but has become critical due to the threats to forests imposed by climate change. Populus alba ‘Berolinensis,’ also known “Yinzhong poplar,” is a triploid poplar from northeast China. This hybrid triploid poplar is widely used as a landscape ornamental and in urban forestry owing to its adaptation to adverse environments and faster growth than its parental diploid. It is an artificially synthesized male allotriploid hybrid, with three haploid genomes of P. alba ‘Berolinensis’ originating from different poplar species, so it is attractive for studying polyploidy genomic mechanisms in heterosis. In this study, we focused on the allelic genomic interactions in P. alba ‘Berolinensis,’ and generated a high‐quality chromosome‐level genome assembly consisting of 19 allelic chromosomes. Its three haploid chromosome sets are polymorphic with an average of 25.73 nucleotide polymorphism sites per kilobase. We found that some stress‐related genes such as RD22 and LEA7 exhibited sequence differences between different haploid genomes. The genome assembly has been deposited in our polyploid genome online analysis website TreeGenomes (https://www.treegenomes.com). These polyploid genome‐related resources will provide a critical foundation for the molecular breeding of P. alba ‘Berolinensis’ and help us uncover the allopolyploidization effects of heterosis and abiotic stress resistance and traits of polyploidy species in the future.
Birthweight and gestational age in the Faroe Islands: A comparison between birthweight and gestational age in the Faroe Islands and other Nordic countries
Authors: Olsen Sunnvá Hanusardóttir , Reynstind Diana , Hallgrímsson Hlynur , Kesmodel Ulrik Schiøler 
Published: February 2023

AbstractIntroductionThis study aimed to examine Faroese infants' birthweight and gestational age in 2010–2019 and compare these findings with other Nordic countries. Risk factors for high birthweight among Faroese infants were also investigated in this study.Material and methodsAll singleton liveborn infants registered in the Faroese Birth Registry in 2010–2019 were included in the study (n = 6121). A comparison was made with data on birthweight and gestational age from Denmark, Iceland, Norway, and Sweden.ResultsThe mean birthweight increased significantly from 3652 g (95% confidence interval [CI]: 3505–3699 g) in 2010 to 3745 g (95% CI: 3700–3790 g) in 2019, a mean increase in birthweight of 93 g (95% CI: 28–158 g) (p < 0.05). The birthweight increased 186 g (95% CI: 179–193 g) for each gestational week and 11 g (95% CI: 7–15 g) for each year. Changes in gestational age explained 31% of the change in birthweight. The proportion of infants weighing 4500 g or more increased significantly from 6.1% in 2010 to 9.6% in 2019 (p < 0.05). The risk of giving birth to an infant weighing 4000 g or more was consistently associated with previously giving birth (OR 1.98 (95% CI: 1.71–2.30)) and gestational age (OR 1.28 (95% CI: 1.23–1.33) per week increase in gestational age). Infants born in gestational weeks 40 and 42 in 2019 had a higher birthweight z‐score than infants born in gestational weeks 40 and 42 in 2010. Compared to other Nordic countries, Faroese infants' mean birthweight was high, the Faroe Islands had a higher number of infants born with a weight of 4000 g or more and a higher proportion of infants born in gestational week 41 or later (31.5%).ConclusionsOur results showed that the mean birthweight and the proportion of infants with high birthweight significantly increased during 2010–2019 in the Faroe Islands. The mean birthweight, the proportion of infants with high birthweight and the gestational age at birth for Faroese infants was higher than all other Nordic countries. The reasons for this require further investigation.
Conspiracy theories and clinical decision‐making
Authors: Stout Nathan 
Published: February 2023

AbstractWhen a patient's treatment decisions are the product of delusion, this is often taken as a paradigmatic case of undermined decisional capacity. That is to say, when a patient refuses treatment on the basis of beliefs that in no way reflect reality, clinicians and ethicists tend to agree that their refusal is not valid. During the COVID‐19 pandemic, however, we have witnessed many patients refuse potentially life‐saving interventions not based on delusion but on conspiracy beliefs. Importantly, many of the beliefs espoused by conspiracy theorists resemble delusions in a number of relevant ways. For instance, conspiracy beliefs often posit states of affairs that could not possibly exist in the world, they are recalcitrant in the face of disconfirming evidence, and they tend to put the believer in a state of paranoia. Given these similarities, how should we think about conspiracy theorists' capacity for making clinical decisions? In this paper, I attempt to answer this question by first offering an account of just what makes some set of beliefs count as a conspiracy theory. Second, I attempt to disambiguate conspiracy beliefs from delusions by exploring important conceptual and psychological features of both. Finally, I apply standard criteria for assessing a patient's decision‐making capacity to instances of conspiracy beliefs and argue that, although the picture is muddy, there may be cases in which conspiracy beliefs undermine capacity. I end by exploring the implications that this might have for surrogate decision‐making and addressing potential objections.
Workplace gender segregation in standard and non‐standard employment regimes in the US labour market
Authors: Makarevich Alex 
Published: February 2023

AbstractThis study provides a comprehensive analysis of workplace gender segregation in non‐standard employment in the United States. It compares segregation in standard and three non‐standard work arrangements paying special attention to independent contracting – a segment of contingent employment representing novel and consequential developments in work organization. In line with the prediction that inequality is lower in more marketized sectors of the labour market, my analyses based on a representative sample of the contemporary US workforce reveal that workplace gender segregation is lower in non‐standard employment. I further find that the degree of segregation corresponds to the degree of attachment to the employer and that segregation is lower in segments of the economy with higher market competition. Overall, my analyses indicate that a shift towards alternative work arrangements can reduce overall workplace segregation but does not lead to uniform desegregation across occupations, and that institutions of employment and market pressures faced by employers play significant roles in the effect of alternative work arrangements on workplace segregation.
Long‐term outcomes of total colectomy for severe constipation
Authors: Johnston Ben J. , Clark David A. , Warwick Andrea M. 
Published: February 2023

AbstractAimSurgery for constipation is usually reserved for patients with severe and refractory symptoms because of concerns about perioperative morbidity and unpredictable functional outcomes. The aim of this paper is to identify the long‐term outcomes of patients who have undergone total colectomy and ileorectal anastomosis for severe constipation.MethodPatients who had undergone a total colectomy and ileorectal anastomosis for severe constipation were identified from a prospectively maintained database and sent a postal survey assessing functional symptoms, patient satisfaction and the impact of symptoms on quality of life. Information regarding the surgery, perioperative complications and hospitalizations were also collected. Functional outcomes of the surgery were evaluated with the Gastrointestinal Quality of Life Index, St Marks incontinence score, Wexner continence score, obstructed defaecation syndrome score and Cleveland Clinic constipation score.ResultsSeventy‐one questionnaires were posted and 32 (45%) patients responded. The mean time since surgery was 15.3 years (range 2.9–30.4 years) Most patients were happy with the surgery. Ongoing symptoms were common, the most frequent of these were abdominal pain, experienced by 23 patients (71.9%), and faecal incontinence, experienced by 17 patients (53%). Fourteen patients (43.8%) required subsequent hospital admission due to bowel obstruction and eight patients (25%%) had subsequent surgery for adhesions. There was an association between patient quality of life and subsequent surgeries.ConclusionMost patients were happy and viewed their life as improved following total colectomy for severe constipation. This is despite a high rate of ongoing functional symptoms.
Deliberate delays in offering abortion to pregnant women with fetal anomalies after 24 weeks' gestation at a centre in South Africa
Authors: Kleinsmidt Anita , Malope Malebo , Urban Michael 
Published: February 2023

AbstractSouth Africa has an abortion law which codifies the broad themes of reproductive rights set out in the Constitution of South Africa, other laws and national guidelines. Certain wording of the conditions in the Choice Act for abortion after 20 weeks' gestation, are open to interpretation, being ‘severe malformation of the fetus’ and ‘risk of injury to the fetus’. From 24 weeks onwards, abortion is carried out by feticide/induced fetal cardiac asystole (‘IFCA’) and subsequent induction of labour in South Africa. Some maternal‐fetal units have developed guidelines to assist clinicians and patients in decision‐making around eligibility for abortion after 20 weeks' gestation, given the broad terms in the law. We consider the guideline used by an institution in the Western Cape for abortion after 23 weeks and 6 days gestation, in terms of its alignment with the law on reproductive rights and its compliance with fair and transparent procedures. We also note its effect on respect for patients and on staff professionalism.
Once‐weekly semaglutide use in patients with type 2 diabetes: Real‐world data from the SURE Italy observational study
Authors: Napoli Raffaele , Berra Cesare , Catarig Andrei‐Mircea , Di Loreto Chiara , Donatiello Emily , Berentzen Tina Landsvig , Pitocco Dario , Giorgino Francesco 
Published: February 2023

AbstractAimsSURE Italy, a multicentre, prospective, open‐label, observational, real‐world study, investigated once‐weekly semaglutide in patients with type 2 diabetes (T2D) in routine clinical practice.Materials and MethodsAdults with T2D and ≥1 documented glycated haemoglobin (HbA1c) level within 12 weeks of semaglutide initiation were enrolled. The primary endpoint was change in HbA1c from baseline to end of study (EOS; ~30 weeks). Other endpoints included changes in body weight, waist circumference and patient‐reported outcomes, and the proportion of patients achieving HbA1c <7.0% or <6.5%, weight loss ≥5% and a post‐hoc composite endpoint (HbA1c reduction of ≥1%‐point and weight loss ≥5%). These endpoints were reported for patients on semaglutide at EOS [effectiveness analysis set (EAS)]. Safety data were reported in the full analysis set.ResultsOf 579 patients who initiated semaglutide (full analysis set), 491 completed the study on treatment (EAS). Mean baseline HbA1c was 8.0%, and 20.7% (120 of 579) of patients had HbA1c <7.0%. Mean semaglutide dose at EOS was 0.66 ± 0.28 mg. In the EAS, mean HbA1c and body weight decreased by 1.1%‐point (95% confidence interval 1.20, 1.05; P < .0001) and 4.2 kg (95% confidence interval 4.63, 3.67; P < .0001), respectively. At EOS, 61.7% and 40.8% of patients achieved HbA1c <7.0% and <6.5%, respectively, 40.5% achieved weight loss ≥5% and 25.3% achieved the post‐hoc composite endpoint. Patient‐reported outcomes improved from baseline to EOS. No new safety concerns were identified.ConclusionsIn routine clinical practice in Italy, patients with T2D treated with once‐weekly semaglutide for 30 weeks achieved clinically significant improvements in HbA1c, body weight and other outcomes.
Loss of ATP2C1 function promotes trafficking and degradation of NOTCH1: Implications for Hailey‐Hailey disease
Authors: Zonfrilli Azzurra , Truglio Federica , Simeone Alessandra , Pelullo Maria , De Turris Valeria , Benelli Dario , Checquolo Saula , Bellavia Diana , Palermo Rocco , Uccelletti Daniela , Screpanti Isabella , Cialfi Samantha , Talora Claudio 
Published: February 2023

AbstractHailey‐Hailey disease (HHD) is a rare autosomal dominantly inherited disorder caused by mutations in the ATP2C1 gene that encodes an adenosine triphosphate (ATP)‐powered calcium channel pump. HHD is characterized by impaired epidermal cell‐to‐cell adhesion and defective keratinocyte growth/differentiation. The mechanism by which mutant ATP2C1 causes HHD is unknown and current treatments for affected individuals do not address the underlying defects and are ineffective. Notch signalling is a direct determinant of keratinocyte growth and differentiation. We found that loss of ATP2C1 leads to impaired Notch1 signalling, thus deregulation of the Notch signalling response is therefore likely to contribute to HHD manifestation. NOTCH1 is a transmembrane receptor and upon ligand binding, the intracellular domain (NICD) translocates to the nucleus activating its target genes. In the context of HHD, we found that loss of ATP2C1 function promotes upregulation of the active NOTCH1 protein (NICD‐Val1744). Here, deeply exploring this aspect, we observed that NOTCH1 activation is not associated with the transcriptional enhancement of its targets. Moreover, in agreement with these results, we found a cytoplasmic localization of NICD‐Val1744. We have also observed that ATP2C1‐loss is associated with the degradation of NICD‐Val1744 through the lysosomal/proteasome pathway. These results show that ATP2C1‐loss could promote a mechanism by which NOTCH1 is endocytosed and degraded by the cell membrane. The deregulation of this phenomenon, finely regulated in physiological conditions, could in HHD lead to the deregulation of NOTCH1 with alteration of skin homeostasis and disease manifestation.