bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odor modality is transmitted to cortical brain regions from the olfactory bulb
Authors: Craft Michelle F. , Barreiro Andrea K. , Hari Gautam Shree , Shew Woodrow L. , Ly Cheng 
Published: February 2023

AbstractOdor perception is the impetus for important animal behaviors with two predominate modes of processing: odors pass through the front of the nose (orthonasal) while inhaling and sniffing, or through the rear (retronasal) during exhalation and while eating. Despite the importance of olfaction for an animal’s well-being and that ortho and retro naturally occur, it is unknown how the modality (ortho versus retro) is even transmitted to cortical brain regions, which could significantly affect how odors are processed and perceived. Using multi-electrode array recordings in tracheotomized anesthetized rats, which decouples ortho-retro modality from breathing, we show that mitral cells in rat olfactory bulb can reliably and directly transmit ortho versus retronasal modality with ethyl butyrate, a common food odor. Drug manipulations affecting synaptic inhibition via GABAAlead to worse decoding of ortho versus retro, independent of whether overall inhibition increases or decreases, suggesting that the olfactory bulb circuit may naturally favor encoding this important aspect of odors. Detailed data analysis paired with a firing rate model that captures population trends in spiking statistics shows how this circuit can encode odor modality. We have not only demonstrated that ortho/retro information is encoded to downstream brain regions, but also use modeling to demonstrate a plausible mechanism for this encoding: due to synaptic adaptation, it is the slower time course of the retronasal stimulation that causes retronasal responses to be stronger and less sensitive to inhibitory drug manipulations than orthonasal responses.New and NoteworthyWhether ortho (sniffing odors) versus retro (exhalation and eating) is encoded from the olfactory bulb to other brain areas is not completely known. Using multi-electrode array recordings in anesthetized rats, we show that the olfactory bulb transmits this information downstream via spikes. Altering inhibition degrades ortho/retro information on average. We use theory and computation to explain our results, which should have implications on cortical processing considering that only food odors occur retronasally.
Protein embeddings improve phage-host interaction prediction
Authors: Gonzales Mark Edward M. , Ureta Jennifer C. , Shrestha Anish M.S. 
Published: February 2023

AbstractWith the growing interest in using phages to combat antimicrobial resistance, computational methods for predicting phage-host interactions have been explored to help shortlist candidate phages. Most existing models consider entire proteomes and rely on manual feature engineering, which poses difficulty in selecting the most informative sequence properties to serve as input to the model. In this paper, we framed phage-host interaction prediction as a multiclass classification problem, which takes as input the embeddings of a phage’s receptor-binding proteins, which are known to be the key machinery for host recognition, and predicts the host genus. We explored different protein language models to automatically encode these protein sequences into dense embeddings without the need for additional alignment or structural information. We show that the use of embeddings of receptor-binding proteins presents improvements over handcrafted genomic and protein sequence features. The highest performance was obtained using the transformer-based protein language model ProtT5, resulting in a 3% to 4% increase of weighted F1 scores across different prediction confidence threshold,compared to using selected handcrafted sequence features.Author summaryAntimicrobial resistance is among the major global health issues at present. As alternatives to the usual antibiotics, drug formulations based on phages (bacteria-infecting viruses) have received increased interest, as phages are known to attack only a narrow range of bacterial hosts and antagonize the target pathogen with minimal side effects. The screening of candidate phages has recently been facilitated through the use of machine learning models for inferring phage-host pairs. The performance of these models relies heavily on the transformation of raw biological sequences into a collection of numerical features. However, since a wide array of potentially informative features can be extracted from sequences, selecting the most relevant ones is challenging. Our approach eliminates the need for this manual feature engineering by employing protein language models to automatically generate numerical representations for specific subsets of tail proteins known as receptor-binding proteins. These proteins are responsible for a phage’s initial contact with the host bacterium and are thus regarded as important determinants of host specificity. Our results show that this approach presents improvements over using handcrafted genomic and protein sequence features in predicting phage-host interaction.
Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features
Authors: Rao Srinivasa , Verrill Clare , Cerundolo Lucia , Alham Nasullah Khalid , Kaya Zeynep , O’Hanlon Miriam , Hayes Alicia , Lambert Adam , James Martha , Tullis Iain D. C. , Niederer Jane , Lovell Shelagh , Omer Altan , Lopez Francisco , Leslie Tom , Buffa Francesca , Bryant Richard J. , Lamb Alastair D. , Vojnovic Boris , Wedge David C. , Mills Ian G. , Woodcock Dan J. , Tomlinson Ian , Hamdy Freddie C. 
Published: February 2023

ABSTRACTExtension of prostate cancer beyond the primary site into the surrounding organs by local invasion or nodal metastasis is associated with poor prognosis. The emergence and evolution of cancer clones at this early stage of expansion and spread has not been studied in detail. We performed whole genome sequencing on 42 prostate cancer samples from the prostate, seminal vesicles and regional lymph nodes of five treatment-naive patients with locally advanced disease who underwent radical prostatectomy. Using cancer cell fractions computed from single nucleotide variants and copy number alterations, we reconstructed the tumour phylogenies, which in turn allowed us to infer key molecular steps in the progression of prostate cancer in these individuals. We mapped the clonal composition of cancer sampled across the prostate in each individual and inferred the routes of spread of cancer cells within the prostate and to seminal vesicles and lymph nodes. Based on these data, we delineated the route of tumour progression and metastasis following the transformation of adenocarcinoma to amphicrine morphology, the molecular events leading to whole genome duplication associated with a single clonal expansion and identified putative driver events associated with local invasion and lymph node metastasis. We also correlated genomic changes associated with differences in morphology and identified putative driver events associated with spread to seminal vesicle invasion and lymph node metastasis. Taken together, these findings have implications for diagnosis and risk stratification, in addition to providing a rationale for further studies to characterise the genetic changes associated with morphological transformation. Our results demonstrate the value of integrating multi-region sequencing with histopathological data to study tumour evolution and identify mechanisms of prostate cancer spread.
Does corporate governance affect the performance and stability of Islamic banks?
Authors: Mamatzakis Emmanuel , Alexakis Christos , Yahyaee Khamis Al , Pappas Vasileios , Mobarek Asma , Mollah Sabur 
Published: February 2023

Purpose
This paper aims to investigate the impact of corporate governance practices on cost efficiency and financial stability for a sample of Islamic and conventional banks. In the analysis, the author uses a set of corporate governance variables that include, the board size, board independence, director gender, board meetings, board attendance, board committees, chair independence and CEO characteristics.

Design/methodology/approach
The author uses corporate governance data of Islamic banks that is unique in this field. In the analysis, the author also uses stochastic frontier analysis and panel vector autoregression models to quantify long-run and short-run statistical relationships between the operational efficiency of Islamic Banks and corporate governance practices.

Findings
According to the results, Islamic and conventional banks exhibit important differences in the effects of corporate governance practices on cost efficiency and financial stability. Results show that with a blind general adoption of corporate governance practices, Islamic banks may suffer a loss in their value since the adoption of the third layer of binding practices, over and above the already existing ones, imposed by the Sharia Board and the Board of Directors, may lead to cumbersome business operations. This conclusion is of importance to Islamic Banks since they struggle to survive in a very competitive international environment.

Practical implications
The author believes that the results may be of a certain value to regulators, policymakers and managers of Islamic banks. Based on the results, the author postulate that Islamic banks should select carefully international corporate governance practices.

Social implications
Islamic banks should not adopt additional third layer of binding practices as that would result lower performance and instability that would be damaging for the economy

Originality/value
This study employs a unique sample of Islamic banks that includes corporate governance data hand collected. Our findings of the corporate governance impact on Islamic banks performance and stability are therefore unique in the literature.
Co-creating values for the transformation of scientific and technological achievements: research on the structural hole filling behavior of stakeholders
Authors: Liu Jiayuan 
Published: February 2023

PurposeThis study aims to explore how stakeholders leverage theirguanxiand structural holes to promote knowledge mobilization to increase the performance of sci-tech achievement transformation.Design/methodology/approachThis study conducted questionnaires, a social network analysis and semistructured interviews to examine its hypotheses by gathering data from a university and an enterprise in China.FindingsStructural holes impede knowledge mobilization among stakeholders in their network, butguanximoderates this impeding effect. In addition, knowledge mobilization promotes transformation performance.Originality/valueBy developing a mechanism to illustrate how stakeholders strategically leverage theirguanxiand structural holes to affect the efficacy of knowledge mobilization to increase transformation performance, we reveal how stakeholders interact to co-create values for innovation, thereby contributing to the innovation and knowledge management literature.
Dual solutions on three-dimensional nanofluid flow and heat transfer over a permeable non-linearly shrinking surface with second-order velocity slips
Authors: Roşca Natalia C. , Roşca Alin V. , Pop Ioan 
Published: February 2023

Purpose
This paper aims to present the steady dual solutions on three-dimensional flow and heat transfer of nanofluid over a permeable non-linearly shrinking surface with two-order velocity slips conditions. Boundary layer assumption is considered in the mathematical modelling. Authors comprehend from previous studies and papers that the shrinking surfaces are extremely important in current engineering and environmental systems.

Design/methodology/approach
Using appropriate similarity variables, the full partial differential equations (PDF) are modified into a specific set of ordinary (similar) differential equations (ODE). The resulting non-linear ordinary differential system is then solved both analytically for some particular cases and numerically for the general case using the function bvp4c from MATLAB for characteristic values of the parameters which govern the equations. The transformed mathematical model is analysed using the bvp4c procedure. Based on the given assumptions, this study is able to produce multiple solutions of the problem.

Findings
The ordinary (similarity) differential equations have two branches solutions, upper and lower branch solutions, given some interval of shrinking and velocity slip parameters. The authors consider here a temporal stability analysis, as they want to establish which of the solutions are stable and which are not. In a distinct paragraph, the authors discuss in detail and present in a graphical manner the effects of shrinking and second-order slip flow model on the skin friction coefficient, surface wall heat flux and dimensionless velocity and temperature profiles. The analysis reveals that the second order slip has a big influence on the flow and heat transfer characteristics.

Originality/value
The present discoveries are unique and truly new for the research of the three-dimensional stretching/shrinking forced convection flow and heat transfer nanofluids. The nanofluid is a water-based nanofluid (H2O), which contains one type of nanoparticles, namely, copper (Cu). Of course, the analysis can be further extended considering other types of nanoparticles such as alumina (Al2O3). The authors assume that the thermal equilibrium is reached for the base fluid together with the suspended nanoparticles and that the nanoparticles are uniform in dimension and form.
Strategic management accounting revisited: building on insights from the business model field
Authors: Roslender Robin , Hart Susan , Nielsen Christian 
Published: February 2023

Purpose
This paper aims to identify and discuss insights from the business model field on the creation and delivery of value to customers that provide new thinking in relation to the strategic management accounting field.

Design/methodology/approach
The customer emphases exhibited in parts of the extant strategic management accounting literature are highlighted and amplified using insights from the business model literature, including those relating to value propositions, customer value creation and delivery and meeting customers’ value expectations.

Findings
The paper demonstrates that in addition to providing valuable insights for accounting to management, an extended strategic management accounting concept enables accounting and reporting to customers, now identified as major stakeholders, in the context of integrated reporting.

Practical implications
Through its customer resonances, the paper affirms strategic management accounting’s practical utility for organisations seeking a strong position in highly competitive marketplaces, via the addition of a focus on accounting to customers.

Originality/value
The paper’s use of insights from the business model literature further reinforces the view that strategic management accounting potentially constitutes a pivotal development within both managerial and financial accounting and reporting.
Citizens' perceptions of World Heritage values: the case of Cuenca, Ecuador
Authors: Molina Barbara , Eljuri Gabriela , Roigé Ventura Xavier 
Published: February 2023

PurposeThis paper aims to study possible differences between the Outstanding Universal Value (OUV) defined in the designation of Cuenca as a World Heritage (WH) site and its inhabitants' perceptions of heritage value. The study is based on research conducted in the historic centre of Cuenca in Ecuador, which was accorded WH status in 1999.Design/methodology/approachThe research employs both quantitative and qualitative methodologies, providing a complementary approach to the research subject. Quantitative research involved a probability survey of 400 informants randomly selected from the population of the canton of Cuenca, while qualitative research included 40 semi-structured interviews with residents and traders in the historic centre and 150 further written consultations with residents of the city.FindingsFollowing the introduction, methodology and description, the paper presents the data gathered from the survey and interviews. These indicate inhabitants' perceptions of the meaning, values, and uses of WH in Cuenca and reveal differences between their perceptions and those of the official OUV.Originality/valueAlthough there are several studies on WH residents' perceptions of UNESCO OUV, few highlight the mismatch between local community views of heritage and those established by UNESCO. This study reflects critically on the concept of OUV, which is based on technical and political criteria rather than social participation. The study employs methodologies that could be applied in other case studies and used to improve heritage management. This is the only study on local perceptions of Cuenca's OUV.
You can't shop with us: how US-based, value- and mid-market online clothing retailers position their plus-size female clothing sections
Authors: Shelton Summer Suzanne , Bradshaw Amanda S. , Cretul Matthew , Treise Debbie 
Published: February 2023

PurposePlus-size women represent a large consumer segment that has grown in popularity with the fashion industry, retailers and advertisers. Despite advancements in clothing availability for plus-sized women, the shopping experience for these women (compared with that of straight-size women) often still falls short. The current experience leaves plus-sized women feel like a second-class, minority group despite the fact that the majority of women in USA are considered plus-size. The purpose of this study was to assess how US-based, value- and mid-market online clothing retailers position their plus-size female clothing sections in their site navigation.Design/methodology/approachThis study assessed the websites of N = 68 popular plus- and straight-sized US-based, value- and mid-market retailers to evaluate the placement of, and options available in, their plus-sized clothing sections.FindingsFindings revealed that the majority of retailers completely separated out the plus-sized section from the straight-sized section and that the language used to describe plus-size clothing was body-focused (versus clothing-focused for straight-size clothing sections). Theoretical and practical implications for marketers, advertisers and retailers are discussed.Originality/valueThis is the first study to assess the separation of plus- and straight-sized clothing sections in online retail spaces. As brands begin to consider combining plus- and straight-sized clothing sections (see Old Navy), it is important to assess how wide-spread the separation of sections currently is in online retail environments.
Does congruency matter for online green demarketing campaigns? Examining the effects of retargeting display ads embedded in different browsing contexts
Authors: Yoon Hye Jin , Lee Yoon-Joo , Sun Shuoya , Joo Jinho 
Published: February 2023

PurposeGreen demarketing, which promotes anti-consumption as a more extreme sustainability tactic, could help consumers and societies move toward healthier consumption patterns while building strong, long-lasting relationships with consumers. As even the most committed brands find the need to oscillate between demarketing and conventional marketing for survival, this research tests how the congruency of the campaign shown on a brand's home page (owned media) and a following retargeting ad (paid media) could impact perceived congruency and further downstream effects. In doing so, this research proposes that the media context (i.e. news or shopping browsing context) in which the retargeting ad is embedded could determine how much congruency of the demarketing campaign across owned and paid media matters.Design/methodology/approachAn experiment with a 2 (home page content: green vs. demarketing) × 2 (retargeting ad content: product vs. demarketing) × 2 (browsing context: shopping vs. news) between-subjects factorial design was employed with an online panel of 430 participants. The participants first saw the brand's home page content, then were assigned to a website browsing context where the retargeting ad of the brand was embedded.FindingsIn a news browsing context, users perceived higher congruency when product retargeting ads (vs. demarketing) were shown after a green home page exposure and when demarketing retargeting ads (vs. products) were delivered after a demarketing home page. The elevated perceived congruency successfully led to higher ad argument and ad attitude. These differences were not present in a shopping browsing context. These results showed that the congruency between the home page and the retargeting ad for demarketing campaigns mattered more in certain media contexts (i.e. news browsing context).Originality/valueThe study closes the empirical gap in demarketing brand activism campaigns by demonstrating when and how congruency between multiple owned and paid channels for demarketing campaigns impacts consumer responses. This study provides evidence of how the match of the demarketing campaign shown on a brand's home page and a following retargeting ad could impact perceived congruency and further downstream effects of ad argument and ad attitude while considering different browsing context effects.
Network capabilities and firm performance: a meta-analytical study
Authors: Wegner Douglas , Santini Fernando De Oliveira , Toigo Taisson 
Published: February 2023

PurposeThis study aims to perform a meta-analysis about network capabilities (NCs) and how they influence firm performance. Previous studies present distinct results regarding this relationship due to samples, cultural and contextual differences.Design/methodology/approachThe authors conducted a meta-analysis of 33 papers published between 2008 and 2019.FindingsThe results contribute to theory and practice by (1) synthesizing previous research, testing the relationship between NCs and firm performance; (2) confirming the influence of entrepreneurial orientation on NCs; (3) showing how contextual variables affect the relationship between NCs and firm performance; (4) suggesting that NCs moderate the relationship between entrepreneurial orientation and firm performance.Practical implicationsFurthermore, the authors also offer managerial implications. Firms should consider investing in developing NCs to foster performance. Moreover, the contextual variables we investigated show that firms in specific contexts may experience a higher relevance of their NCs for firm performance.Originality/valueThis meta-analysis contributes to the management literature by offering a set of empirical generalizations, including relationship direct, mediation and moderation effects about network capabilities.