bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChipFilter: Microfluidic Based Comprehensive Sample Preparation Methodology for Metaproteomics
Authors: Ravi Kumar Ranjith Kumar , Ndiaye Massamba Mbacke , Haddad Iman , Vinh Joelle , Verdier Yann 
Published: January 2023

ABSTRACTMetaproteomic approach is an attractive way to describe a microbiome at the functional level, allowing the identification and quantification of proteins across a broad dynamic range as well as detection of post-translational modifications. However, it remains relatively underutilized, mainly due to technical challenges that should be addressed, including the complexity in extracting proteins from heterogenous microbial communities.Here, we show that a ChipFilter microfluidic device coupled to LC-MS/MS can successfully be used for identification of microbial proteins. Using cultures ofE. coli, B. subtilisandS. cerevisiae, we have shown that it is possible to directly lyse the cells and digest the proteins in the ChipFilter to allow higher number of proteins and peptides identification than standard protocols, even at low cell density. The peptides produced are overall longer after ChipFilter digestion but show no change in their degree of hydrophobicity. Analysis of a more complex mixture of 17 species from the gut microbiome showed that the ChipFilter preparation was able to identify and estimate the amount of 16 of these species.These results show that ChipFilter can be used for the proteomic study of microbiomes, in particular in the case of low volume or low cell density.
Mind your own business and communicate the same! – signaling content that makes investors interested
Authors: Singhal Nidhi , Kapur Deepak 
Published: January 2023

Purpose
This study aims to understand the impact of underlying theme in the communication on social media on funding received by early-stage start-ups.

Design/methodology/approach
The study is based on empirical testing of data of 849 start-ups and more than 130K tweets. Machine learning (ML) model has been used for text classification of 130K+ tweets. Causal mediation analysis with bootstrapping is carried out for hypothesis testing.

Findings
Tweets addressing quality-related uncertainty are a predictor of amount of funds raised. Audience response acts as a mediator between tweets focusing on relational orientation and amount of funds raised.

Research limitations/implications
The authors advance signaling theory by theorizing and investigating the importance of signal content. Endogenous signal of quality directly influences the start-ups outcomes, while exogenous signal helps disseminate information and influence the success.

Practical implications
Entrepreneurs should put in concerted effort to reduce uncertainty about the start-ups. Value creation is a central concept for start-ups; however, communicating value should be the dominant part of social media strategy.

Originality/value
Computer-based language processing techniques have amplified the research focused on content. To the best of the authors’ knowledge, this is the first comprehensive study that explores underlying themes of communication of start-ups and their impact on acquiring funds.
Successional patterns of terrestrial wildlife following deglaciation
Authors: Sytsma Mira L. T. , Lewis Tania , Bakker Jonathan D. , Prugh Laura R. 
Published: January 2023

Abstract

Disturbance is a key driver of community assembly and patterns of diversity. Whereas successional changes in vegetation have been well‐studied, postdisturbance successional patterns of wildlife communities remain poorly understood.

Here, we investigated the roles of site age and habitat in shaping community assembly and the diversity of terrestrial mammals in Glacier Bay National Park, Alaska (GBNP), which has undergone the most rapid and extensive deglaciation in the world since the Little Ice Age. Deglaciation has extensively altered the landscape, opening up new habitat for recolonization by plants and animals.

We used camera traps, small mammal trapping and vegetation surveys to investigate the patterns of mammalian succession and beta diversity following deglaciation, using a space‐for‐time substitution across 10 sites during summers 2017 and 2018. Site age and habitat characteristics were not strongly correlated (r < 0.46), allowing the influences of time since disturbance and habitat changes to be distinguished.

PERMANOVA analyses indicated that mammal community assembly was more strongly influenced by site age than habitat, whereas habitat and age had similar effects on beta (between site) diversity. Beta diversity was higher for smaller, less mobile mammals than larger, more mobile mammals and was primarily driven by species turnover among sites, whereas relative turnover was much lower for larger mammals. A comprehensive review of historical distributions of mammals in GBNP supported our findings that species turnover is a driving influence of community assembly for smaller mammals.

Our results indicate that body size of mammals may play an important role in shaping colonization patterns postdisturbance, likely via size‐related differences in mobility. Patterns of wildlife community assembly may therefore not track vegetation succession following disturbances if there are barriers to movement or if dispersal ability is limited, highlighting the importance of incorporating landscape connectivity and species traits into wildlife conservation efforts following disturbances. This knowledge may improve predictions of mammalian community assembly following major disturbance events.
Waiting during disasters: Negotiating the spatio‐temporalities of resilience and recovery
Authors: Sou Gemma , Howarth Kirsten 
Published: January 2023

AbstractAlways spatial, waiting time is the observation of past‐present‐future, and temporality is the condition of being bounded by time. Both are mechanisms of state governance that control how and when families recover from rapid‐onset humanitarian disasters. Analysing these spatio‐temporalities reveals how families leverage resources to engage in acts of resilience that challenge the state’s spatio‐temporal control of recovery. A case study focuses on the aftermath of Hurricane Maria, which devastated Puerto Rico in 2017. We draw on qualitative longitudinal research to explore politicised spatio‐temporal experiences of waiting for the state to fix public infrastructures; approve financial support; and provide access to affordable consumables—which all shape families’ recovery rates and pathways. Disaster‐affected families do not passively wait for the state and often leverage their incomes and social networks to engage in resilience‐based strategies that ease their everyday lives and enable recovery while waiting for the state. Waiting feels more arduous for families with fewer resources and when there is uncertainty about access to the state and how and when to begin certain recovery activities. Waiting in disasters can also provide space for collective socio‐political practices such as community gardening to emerge in neighbourhoods. For researchers of disasters, this article highlights the spatio‐temporal dimensions of grassroots resilience and the ways in which state power and citizen agency interact in ways that subvert state control of families’ recovery rates in heterogeneous ways. Research on waiting during disasters has great potential to inform and reform governance for resilience and recovery.
What is a static head measurement? Evaluating structural error and implications for regional groundwater modeling
Authors: Abrams Daniel B. , Cullen Cecilia , Ghiami Shomami Fereshteh 
Published: January 2023

AbstractMost groundwater modelers avoid using static heads measured from active production wells because they can introduce a bias into model calibration. However, in the deep confined Cambrian‐Ordovician Sandstone Aquifer System in the Central Midcontinent of North America, dedicated observation wells are sparse and remote from areas of most concentrated pumping. As a result, in areas where drawdown is the greatest and modeling is most needed, only static heads from production wells are available for calibration. This paper evaluates two leading sources of discrepancies in using production well data, spatial and temporal structural error (S.E.). A simple Theis solution is used to evaluate the potential magnitude of spatial S.E. when calibrating a regional MODFLOW model with coarse cell resolution. Despite theoretical analyses indicating that spatial S.E. could be significant, statistical analysis of the model results suggests that temporal S.E. is dominant. Long (ranging over decades) or frequent (monthly) head datasets are key in understanding temporal S.E., to better capture water‐level variability. In this study, the range in static head observations impacted estimates of the remaining time a well could extract water from the aquifer by 0.1 to 16.0 years. This uncertainty in future water supply is highly relevant to stakeholders and must be assessed in hydrographs depicting risk.
Competition-Based Control of the False Discovery Proportion
Authors: Luo Dong , Ebadi Arya , Emery Kristen , He Yilun , Noble William Stafford , Keich Uri 
Published: January 2023

AbstractRecently, Barber and Candès laid the theoretical foundation for a general framework for false discovery rate (FDR) control based on the notion of “knockoffs.” A closely related FDR control methodology has long been employed in the analysis of mass spectrometry data, referred to there as “target–decoy competition” (TDC). However, any approach that aims to control the FDR, which is defined as the expected value of the false discovery proportion (FDP), suffers from a problem. Specifically, even when successfully controlling the FDR at level α, the FDP in the list of discoveries can significantly exceed α. We offer FDP-SD, a new procedure that rigorously controls the FDP in the knockoff/TDC competition setup by guaranteeing that the FDP is bounded by α at a desired confidence level. Compared with the recently published framework of Katsevich and Ramdas, FDP-SD generally delivers more power and often substantially so in simulated and real data.
Effects of phonological awareness and morphological awareness on blind students' reading comprehension
Authors: Chen Hongjun , Zhao Ying , Wu Xinchun , Sun Peng , Feng Jie , Xie Ruibo , Wang Haolan 
Published: January 2023

AbstractThe exploration of blind students' reading skills is needed not only for further understanding their reading development but also for providing targeted suggestions for practical education. This study aims to examine the relations among phonological awareness (PA), homograph awareness (HA), compounding awareness (CA) and reading comprehension (RC), and explore the mediating effect of listening comprehension (LC) in Chinese blind students from elementary school. A total of 148 blind and 302 sighted elementary school students completed assessments of PA, HA, CA, LC and RC. The results found that PA, HA and CA were important variables that predicted Chinese blind and sighted students' RC not only directly but also indirectly through LC, which varied across different grades. The findings suggest that there were many similarities that exist in the influencing mechanism of RC between Chinese blind and sighted students.
Once‐daily oral atogepant for the long‐term preventive treatment of migraine: Findings from a multicenter, randomized, open‐label, phase 3 trial
Authors: Ashina Messoud , Tepper Stewart J. , Reuter Uwe , Blumenfeld Andrew M. , Hutchinson Susan , Xia Jing , Miceli Rosa , Severt Lawrence , Finnegan Michelle , Trugman Joel M. 
Published: January 2023

AbstractObjectiveTo assess long‐term safety, tolerability, and efficacy of once‐daily oral atogepant 60 mg in adults with migraine.BackgroundAtogepant is an oral, small‐molecule, calcitonin gene–related peptide receptor antagonist approved for the preventive treatment of episodic migraine.MethodsA 52‐week, multicenter, randomized, open‐label trial of adults (18–80 years) with migraine. Lead‐in trial completers or newly enrolled participants with 4–14 migraine days/month were enrolled and randomized (5:2) to atogepant 60 mg once daily or oral standard care (SC) migraine preventive medication. The primary objective was to evaluate the safety and tolerability of atogepant; safety assessments included treatment‐emergent adverse events (TEAEs), clinical laboratory evaluations, vital signs, and Columbia‐Suicide Severity Rating Scale scores. Efficacy assessments (atogepant only) included change from baseline in mean monthly migraine days (MMDs) and the proportion of participants with reductions from baseline of ≥50%, ≥75%, and 100% in MMDs.ResultsThe trial included 744 participants randomized to atogepant 60 mg (n = 546) or SC (n = 198). The atogepant safety population was 88.2% female (n = 479/543) with a mean (standard deviation) age of 42.5 (12.0) years. TEAEs occurred in 67.0% (n = 364/543) of participants treated with atogepant 60 mg. The most commonly reported TEAEs (≥5%) were upper respiratory tract infection (10.3%; 56/543), constipation (7.2%; 39/543), nausea (6.3%; 34/543), and urinary tract infection (5.2%; 28/543). Serious TEAEs were reported in 4.4% (24/543) for atogepant. Mean (standard error) change in MMDs for atogepant was −3.8 (0.1) for weeks 1–4 and −5.2 (0.2) at weeks 49–52. Similarly, the proportion of participants with ≥50%, ≥75%, and 100% reductions in MMDs increased from 60.4% (310/513), 37.2% (191/513), and 20.7% (106/513) at weeks 1–4 to 84.2% (282/335), 69.9% (234/335), and 48.4% (162/335), at weeks 49–52.ConclusionDaily use of oral atogepant 60 mg for preventive treatment of migraine during this 1‐year, open‐label trial was safe, well tolerated, and efficacious.
Post‐vaccination headache reporting: Trends according to the Vaccine Adverse Events Reporting System
Authors: Cocores Alexandra N. , Goadsby Peter J. , Monteith Teshamae S. 
Published: January 2023

AbstractObjectiveTo assess the characteristics and associated disability of headache as an adverse event following vaccination.BackgroundAccording to clinical trials and post‐licensure surveillance, headache is a common symptom of vaccines, yet systematic investigations of post‐licensure reports of this adverse event are lacking.MethodsThis was a retrospective database analysis study. We searched the Vaccine Adverse Events Reporting System (VAERS) database completed from July 1990 to June 2020 (a 30‐year period prior to the start of COVID‐19 pandemic) to identify reports of headache. We evaluated epidemiological features, including event characteristics, patient demographics, and vaccine type.ResultsIn those aged 3 years or older, headache was the fifth most reported adverse symptom, present in 8.1% (43,218/536,120) of all reports. Of headache reports, 96.3% (41,635/43,218) included the code “headache” not further specified. Migraine was coded in 1973 cases, although almost one‐third (12,467/41,808; 29.8%) of headache reports without a migraine code mention nausea or vomiting. The onset of symptoms was within 1 day of vaccination in over two‐thirds of cases. The majority of reports were classified as not serious; about one‐third involved emergency room or office visits. Of the 43,218 total headache reports, only a minority involved hospitalizations (2624; 6.1%) or permanent disability (1091; 2.5%), females accounted for 68.9% (29,771) and males for 29.5% (12,725), patients aged 6 to 59 years represented 67.3% (29,112), and over one‐third of cases were reported after herpes zoster (8665; 20.1%) and influenza (6748; 15.6%) vaccinations.ConclusionIn a national surveillance system, headache was a commonly reported post‐vaccination adverse event; a small subset of reports was considered serious. The development of standardized vaccine‐related case definitions could be useful for better evaluating headache as an adverse event during vaccine development, and may reduce vaccine hesitancy especially in headache‐prone individuals.
Socioeconomic and geographic inequalities in headache disability in Brazil: The 2019 National Health Survey
Authors: Oliveira Arão , Bensenor Isabela , Goulart Alessandra , Mercante Juliane , Peres Mario 
Published: January 2023

AbstractObjectiveTo map the socioeconomic and geographic inequalities in headache disability in Brazil.BackgroundHeadache disability and its social determinants are poorly investigated in Brazil.MethodsThis is a secondary, cross‐sectional analysis of the 2019 National Health Survey database, a representative sample of the Brazilian population. Working‐aged Brazilians (aged ≥14 years) were included in the analyses (n = 225,563). Headache disability was inquired through questions on the number of days the respondent was unable to perform customary daily activities in the past 2 weeks. Proportion estimates and the mean days lost were compared between socioeconomic categories. Sample weights were used.ResultsAmong 14 disease‐related disability groups, headache disability (n = 1228) was the second most prevalent disability in adolescents and fifth among adults aged <50 years. In the headache disability sample, there was a higher proportion of females at 72.4% (95% confidence interval [CI] 68.5%–75.9%), with a mean (95% CI) age of 41.1 (40.1–42.0) years and days lost due to disability of 3.4 (3.2–3.6) days. The sociodemographic distribution across income strata (quartiles) of the headache disability sample showed the highest proportions at the lowest income quartile in the Northeast region (15.4%, 95% CI 12.8%–18.4%), for people of Brown color (17.5%, 95% CI 14.7%–20.7%), and with the lowest education level (l3.6%, 95% CI 11.3%–16.2%). Black people, those from the North region, and those with the lowest education level had more days lost than White people (mean [95% CI] 4.1 [3.5–4.6] vs. 3.1 [2.8–3.4] days, p = 0.008), those from the Southeast region (mean [95% CI] 3.8 [3.4–4.2] vs. 2.8 [2.4–3.3] days, p = 0.022), and people with the highest education level (mean [95% CI] 3.9 [3.6–4.2] vs. 2.8 [2.3–3.3] days, p = 0.005), respectively.ConclusionIn Brazil, headache disability is one of the leading causes of disability and it is characterized by socioeconomic inequalities.
Cutaneous lichenoid drug eruptions: A narrative review evaluating demographics, clinical features and culprit medications
Authors: Maul Julia‐Tatjana , Guillet Carole , Oschmann Anna , Maul Lara Valeska , Meier‐Schiesser Barbara , Stadler Pia‐Charlotte , French Lars E. , Kerl Katrin 
Published: January 2023

AbstractCutaneous lichenoid drug eruptions (LDE) are adverse drug reactions (ADR) characterized by symmetric, erythematous, violaceous papules reminiscent but rarely fully characteristic of lichen planus (LP). We aimed to analyse the literature describing cases of LDE within the last 20 years to provide additional insight into culprit drugs, typical latency to onset of the eruption, the spectrum of clinical presentations, severity and management. A literature search was conducted in MEDLINE between January 2000 and 27 January 2021. The keywords ‘lichenoid drug rash’ and ‘lichenoid drug eruption’ were used. Cases were included if LDE diagnosis was made, and culprit drugs were identified. A total of 323 cases with LDE were identified from 163 published case reports and studies. The mean patient age was 58.5 years (1 month to 92 years), and 135 patients (41.8%) were female. Checkpoint inhibitors (CKI) were the most frequently reported culprit drugs (136 cases; 42.1%), followed by tyrosine kinase inhibitors (TKI) (39 cases; 12.0%) and anti‐TNF‐α‐monoclonal antibodies (13 cases; 4.0%). The latency between initiation of the drug and manifestation was 15.7 weeks (range: 0.1–208 weeks). After discontinuing the culprit drug, the median time to resolution was 14.2 weeks (range: 0.71–416 weeks). One hundred thirty‐six patients (42.1%) were treated with topical, and 54 patients (16.7%) with systemic glucocorticoids. Overall, we conclude that, albeit rare, LDE is challenging to diagnose ADR induced by mostly CKI, TKI, and biologics. Treatment modalities resemble that of lichen planus, and the culprit drugs had to be discontinued in only 26%, which is low compared with other types of adverse drug reactions. This is probably due to the low risk of aggravation (e.g. toxic epidermal necrolysis) if the drug is continued and the benefit/risk ratio favouring the drug, as is often the case in cancer therapy.
“Advocating for what we need”: A CBPR approach to advance care planning in the Latinx older adult community
Authors: Nouri Sarah , Tan Charissa H. , Rangel Mirella , Wertz Molly , Sanchez Adriana , Alvarado Aurora , Arreola Erika , Quinn Mara , Pantilat Steven Z. , Lyles Courtney R. , Ritchie Christine S. , Sudore Rebecca L. 
Published: January 2023

AbstractBackgroundAdvance care planning (ACP) is low among Latinx older adults. We used community‐based participatory research (CBPR) to identify ACP barriers/facilitators and design community‐based ACP events.MethodsIn partnership with community‐based organizations, clinicians, and local government, we formed a Latinx Community Committee (n = 13 community members). We then conducted 6 focus groups with Latinx‐identifying, English or Spanish‐speaking older adults (age ≥ 55), caregivers, and community leaders to assess ACP barriers/facilitators. We analyzed transcripts using thematic analysis and, based on these learnings, designed and implemented community‐based ACP events. Using a validated survey, we assessed acceptability and pre‐to‐post‐event ACP readiness (4‐point scale; 4 = most ready; 0.2 change considered meaningful) with Wilcoxon signed‐rank tests.ResultsFocus groups included 10 Spanish‐speaking older adults, 8 caregivers, and 10 community leaders. Themes highlighted the importance of ACP (e.g., means of advocacy), barriers (e.g., how to start conversations), and facilitators (e.g., trusted community spaces) in the Latinx community. Ninety‐seven people attended 5 events targeting 3 Latinx populations (LGBTQI+, intergenerational, and older adults broadly). Overall pre‐to‐post‐event ACP readiness increased (2.62 (SD 0.97) to 2.95 (SD 0.93); p = 0.05). Readiness to document wishes increased significantly (2.44 (SD 1.0) to 2.98 (SD 0.95); p = 0.003). Most reported being comfortable attending events (85%) and would recommend them to others (90%).ConclusionsThis study describes a feasible, acceptable, and effective CBPR ACP intervention. Co‐developed community events represent a promising approach to reducing disparities in ACP among the Latinx population.