bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of extracellular matrix and its remodeling in the development of cancer and metastasis with a glance at therapeutic approaches
Authors: Afshar Kimiya , Sanaei Mohammad‐Javad , Ravari Mehrnaz Sadat , Pourbagheri‐Sigaroodi Atieh , Bashash Davood 
Published: September 2023

AbstractThe extracellular matrix (ECM) is an inevitable part of tissues able to provide structural support for cells depending on the purpose of tissues and organs. The dynamic characteristics of ECM let this system fluently interact with the extrinsic triggers and get stiffed, remodeled, and/or degraded ending in maintaining tissue homeostasis. ECM could serve as the platform for cancer progression. The dysregulation of biochemical and biomechanical ECM features might take participate in some pathological conditions such as aging, tissue destruction, fibrosis, and particularly cancer. Tumors can reprogram how ECM remodels by producing factors able to induce protein synthesis, matrix proteinase expression, degradation of the basement membrane, growth signals and proliferation, angiogenesis, and metastasis. Therefore, targeting the ECM components, their secretion, and their interactions with other cells or tumors could be a promising strategy in cancer therapies. The present study initially introduces the physiological functions of ECM and then discusses how tumor‐dependent dysregulation of ECM could facilitate cancer progression and ends with reviewing the novel therapeutic strategies regarding ECM.
Electrically stimulated in vitro heart cell mimic of acute exercise reveals novel immediate cellular responses to exercise: Reduced contractility and metabolism, but maintained calcium cycling and increased myofilament calcium sensitivity
Authors: Costa Ana Da Silva , Ghouri Iffath , Johnston Alexander , McGlynn Karen , McNair Andrew , Bowman Peter , Malik Natasha , Hurren Johanne , Bingelis Tomas , Dunne Michael , Smith Godfrey L. , Kemi Ole J. 
Published: September 2023

AbstractCardiac cellular responses to acute exercise remain undescribed. We present a model for mimicking acute aerobic endurance exercise to freshly isolated cardiomyocytes by evoking exercise‐like contractions over prolonged periods of time with trains of electrical twitch stimulations. We then investigated immediate contractile, Ca2+, and metabolic responses to acute exercise in perfused freshly isolated left ventricular rat cardiomyocytes, after a matrix‐design optimized protocol and induced a mimic for acute aerobic endurance exercise by trains of prolonged field twitch stimulations. Acute exercise decreased cardiomyocyte fractional shortening 50%–80% (p < .01). This was not explained by changes to intracellular Ca2+ handling (p > .05); rather, we observed a weak insignificant Ca2+ transient increase (p = .11), while myofilament Ca2+ sensitivity increased 20%–70% (p < .05). Acidic pH 6.8 decreased fractional shortening 20%–70% (p < .05) because of 20%–30% decreased Ca2+ transients (p < .05), but no difference occurred between control and acute exercise (p > .05). Addition of 1 or 10 mM La− increased fractional shortening in control (1 mM La−: no difference, p > .05; 10 mM La−: 20%–30%, p < .05) and acute exercise (1 mM La−: 40%–90%, p < .01; 10 mM La−: 50%–100%, p < .01) and rendered acute exercise indifferent from control (p > .05). Intrinsic autofluorescence showed a resting NADstate of 0.59 ± 0.04 and FADstate of 0.17 ± 0.03, while acute exercise decreased NADH/FAD ratio 8% (p < .01), indicating intracellular oxidation. In conclusion, we show a novel approach for studying immediate acute cardiomyocyte responses to aerobic endurance exercise. We find that acute exercise in cardiomyocytes decreases contraction, but Ca2+ handling and myofilament Ca2+ sensitivity compensate for this, while acidosis and reduced energy substrate and mitochondrial ATP generation explain this.
Pituitary apoplexy associated with bacterial meningitis: Diagnostic dilemma
Authors: Kharel Manish , Hossain Md Fahad 
Published: September 2023

Key Clinical MessagePituitary apoplexy is a rare entity, which is characterized by severe neurological, ophthalmological, and endocrinological complications, with acute adrenal crisis being a major concern. The diagnosis of pituitary apoplexy is challenging, particularly in cases where it coexists with bacterial meningitis, leading to a diagnostic dilemma and delay in treatment. We report a case of a 23‐year‐old female diagnosed with pituitary apoplexy with concurrent bacterial meningitis.
Industrially Promising β‐Ni(OH)2 Nanosheets Self‐Supported Electrode for Highly Efficient Electrooxidation of 5‐Hydroxymethylfurfural
Authors: Liu Fang‐Bing , Lin Nan , Cong Lin‐Chuan , Li Xin‐Xin , Han Fu‐Yu , Xin De‐Yuan , Lin Hai‐Bo 
Published: September 2023

AbstractThe electrocatalytic selective oxidation of 5‐hydroxymethylfurfural (HMF) presents a highly efficient and eco‐friendly method for biomass utilization. Herein, we synthesized pure β‐Ni(OH)2 and amorphous Ni(OH)2 on nickel foam (NF) using a facile stepwise electrodeposition technique and evaluated their catalytic performances for the oxidation of HMF to 2,5‐furan dicarboxylic acid (FDCA). The β‐Ni(OH)2 nanosheets‐decorated electrode (β‐NiNS/NF) exhibited excellent interfacial lattice matching with the substrate nickel, resulting in enhanced electron transfer at the catalyst‐substrate interface, as confirmed by electrochemical analysis. Consequently, the β‐NiNS/NF electrode displayed improved intrinsic electrocatalytic activity and interfacial stability. Additionally, it demonstrated effective HMF adsorption capability. These advantageous properties led to enhanced HMF conversion, selectivity, and structural stability. Notably, the β‐NiNS/NF electrode achieved an unprecedented FDCA yield of 80.6 % under relatively large current density galvanostatic electrolysis commonly used in industry. Moreover, our investigation identified a novel possible oxidation pathway during HMF electrocatalysis. This study not only showcases an efficient and scalable synthetic approach but also highlights the potential of the β‐NiNS/NF electrode for industrial HMF electrocatalytic oxidation under conditions involving relatively large applied currents.
Food Waste Gasification to Produce Hydrogen for Proton Exchange Membrane Fuel Cell Applications: Comparison of Fixed‐Bed and Fluidized‐Bed Gasifiers Models
Authors: Alouani Younes , Saifaoui Dennoun , Alouani Mohamed-Amine , Alouani Abdelkader 
Published: September 2023

AbstractThe proton exchange membrane fuel cell (PEMFC) has been expected to play a pivotal role in energy corridors within the next few years. The gasification of biomass sources is used to produce hydrogen. Many researchers have simulated the biomass gasification model through Aspen Plus to generate hydrogen. However, they have not been targeting the purification of hydrogen gas which is the product of biomass gasification. Thus, the Aspen gasification models for both the fixed and fluidized‐bed gasifiers integrated with the hydrogen purification system to produce hydrogen for PEMFC applications are developed in this work. Food waste is selected as biomass feedstock. The gasifiers have been modeled on Gibbs free minimization energy. Shift reactors along with the preferential oxidation reactor have been employed to limit the amount of CO in the syngas. The validated models were then employed to estimate the performance of both the fixed‐bed food waste gasifier and fluidized‐bed food waste gasifier in terms of syngas produced and hydrogen obtained after purification.
Synthesis and Additive Manufacturing of Hydrazone‐Linked Covalent Organic Framework Aerogels
Authors: Ajnsztajn Alec , Harikrishnan Vijay Vedhan Jayanthi , Alahakoon Sampath B. , Zhu Dongyang , Barnes Morgan , Daum Jeremy , Gayle Jessica , Tomur Gulnihal , Lowenstein Jacob , Roy Soumyabrata , Ajayan Pulickel M. , Verduzco Rafael 
Published: September 2023

AbstractCovalent Organic Frameworks (COFs) are crystalline, porous organic materials. Recent studies have demonstrated novel processing strategies for COFs to form adaptable architectures, but these have focused primarily on imine‐linked COFs. This work presents a new synthesis and processing route to produce crystalline hydrazone‐linked COF gels and aerogels with hierarchical porosity. The method was implemented to produce a series of hydrazone‐linked COFs with different alkyl side‐chain substituents, achieving control of the hydrophilicity of the final aerogel. Variation in the length of the alkyl substituents yielded materials with controllable form factors that can preferentially adsorb water or nonpolar organic solvents. Additionally, a method for additive manufacturing of hydrazone‐linked COFs using hydroxymethylcellulose as a sacrificial additive is presented. This work demonstrates an effective and simple approach to the fabrication of hydrazone COF aerogels and additive manufacturing to produce hydrazone COFs of desired shape.
Mechanochemical Solvent‐Free One‐Pot Synthesis of Poly‐Functionalized 5‐(Arylselanyl)‐1H‐1,2,3‐triazoles Through a Copper(I)‐Catalyzed Click Reaction
Authors: Karmakar Pintu , Karmakar Indrajit , Mukherjee Debojyoti , Bhowmick Anindita , Brahmachari Goutam 
Published: September 2023

AbstractA mechanochemistry‐driven practical and efficient synthetic protocol for accessing diverse series of biologically relevant poly‐functionalized 5‐(arylselanyl)‐1H‐1,2,3‐triazoles through copper(I)‐catalyzed click reaction between aryl/heteroaryl acetylenes, diaryl diselenides, benzyl bromides, and sodium azide has been accomplished under high‐speed ball‐milling. Advantages of this method include operational simplicity, avoidance of using solvent and external heating, one‐pot synthesis, short reaction time in minutes, good to excellent yields, broad substrate scope, and gram‐scale applications. Furthermore, synthesized organoselenium compounds were synthetically diversified to biologically promising selenones.
Recent Advances in Nickel Catalyzed Carbonylative Reactionsviathe Insertion of Carbon Monoxide†
Authors: Chen Xinzhou , Chen Gang , Lian Zhong 
Published: September 2023

Comprehensive SummaryCarbonyl compounds have attracted considerable attention due to their extensive applications in drug discovery. Furthermore, they are important synthetic intermediates for the construction of carbon‐carbon and carbon‐heteroatom bonds. Transition‐metal‐catalyzed carbonylation via the insertion of CO is one of the most efficient and straightforward strategies to access carbonyl compounds. However, most of the transition‐metal‐catalyzed carbonylative reactions require expensive and toxic noble‐metal catalysts. Therefore, there is a growing demand for the exploration of nickel‐catalyzed carbonylative reactions via the insertion of CO due to the earth abundance and low cost of nickel. Compared with the well‐established palladium‐catalyzed carbonylative reactions, nickel‐catalyzed analogous transformations have been relatively underdeveloped. This is primarily because CO strongly binds to nickel, often resulting in catalyst poisoning. In recent years, some research groups have focused on using CO surrogates or NN2pincer nickel catalyst to circumvent the formation of Ni(CO)4. Nickel‐catalyzed carbonylation has been applied in the construction of carbonyl‐containing compounds, such as ketones, carboxylic acids, thioesters, acyl chloride and carboxamides.
Recent Advances in Domino Synthesis of Fused Polycyclic N‐Heterocycles Based on Intramolecular Alkyne Hydroamination under Copper Catalysis
Authors: Jin Zefeng , Shen Guodong , Lv Xin 
Published: September 2023

Comprehensive SummaryFused polycyclic N‐heterocycles are very important scaffolds in biomedicinal chemistry and materials science. Intramolecular alkyne hydroamination is a powerful method for the construction of N‐heterocycles. In the last two decades, copper‐catalyzed domino reactions based on intramolecular alkyne hydroamination has emerged as a robust strategy for assembling various fused polycyclic N‐heterocycles. Great progress has been achieved in this area. This short review covers the advances made in copper‐catalyzed domino synthesis of fused polycyclic N‐heterocycles based on the strategy from 2008 to 2023, and will hopefully serve as an inspiration towards the exploration of new copper‐catalyzed versions of the transformation. The domino transformations are introduced and discussed from five aspects according to the different key processes involved in these reactions.
Asymmetric Hydrogenation of Tetrapyridine‐Type N‐Heteroarenes Using Phosphine‐Free Ruthenium Diamine Catalysts†
Authors: Li Chenghao , Zhang Shu‐Xin , Feng Yu , He Yan‐Mei , Fan Qing‐Hua 
Published: September 2023

Comprehensive SummaryChiral ruthenium‐catalyzed enantioselective hydrogenation of tetrapyridine‐type N‐heteroarenes was firstly developed. The partial reduction of adjacent tetraheteroaromatic substrates proceeded smoothly in the presence of phosphine‐free chiral cationic ruthenium diamine complexes, affording unprecedented high reactivity, enantioselecitivity and diastereoselectivity (up to 93% yield, >99% ee and 92 : 8 dr). The potential application of chiral tetradentate pyridine‐amine products as chiral ligands has been demonstrated in the Cu‐catalyzed asymmetric Friedel–Crafts alkylation reaction between indoles and nitroalkenes.
Mental health of help‐seeking outpatients pre and post COVID‐19: A real‐world data, multicentre study
Authors: Probst Greta Helene , Miller Scott D. , Bargmann Susanne , Flückiger Christoph 
Published: September 2023

AbstractObjectiveA great deal of research addresses the mental health implications of the COVID‐19 pandemic for the general population. Little is known about the implications for mental health of help‐seeking outpatients and for the effectiveness of mental health services. The present study investigated the mental health and treatment response of help‐seeking outpatients before and during the COVID‐19 pandemic.MethodRoutine outcome monitoring data from 3706 clients in the United States and Northern Europe was analysed using multilevel modelling with global subjective well‐being as the dependent variable.ResultsAs opposed to before the pandemic, during the pandemic, well‐being scores were significantly higher at intake and improvement throughout treatment was significantly smaller in the US sample, while both were comparable in the EU sample.ConclusionAlthough there is also evidence of less effective treatments since the pandemic, no conclusive picture emerges that portrays the impact of the pandemic on mental health as uniform. More research is needed to elucidate the impact of the pandemic on the help‐seeking population.
Hirshfeld Surface Analysis of Stable and Metastable Polymorphs of Vanillin
Authors: Sundareswaran Supriya , Karuppannan Srinivasan 
Published: September 2023

AbstractThe intermolecular interactions and the properties of voids present in the stable Form‐I and metastable Form‐II polymorphs of vanillin, a significant pharmaceutical and food material, are investigated through Hirshfeld surface analysis. Form‐I and Form‐II polymorphs of vanillin are separately grown through a template‐induced heterogeneous nucleation process from aqueous solution in the absence and presence of nickel foam as template and their structural parameters are obtained through single crystal X‐ray diffraction (SCXRD) analysis. With this SCXRD data as input, the intermolecular interactions within the grown polymorphs are analyzed by Hirshfeld surface analysis with detailed finger print plot and the area, volume, and percentage of voids present inside the polymorphic structures are identified through the isosurface of the spherical promolecular electron density. The 2D finger print analysis of each of the polymorphs reveals that besides the (H─H) interaction, the (O─H) interaction contributes more to the generation of polymorphs. Furthermore the percentage of volume occupied by the voids in the Form‐I and Form‐II are found to be 11.55% and 19.92%, respectively.
Corporate social responsibility disclosure: Mediating effects of the economic dimension on firm performance
Authors: Escamilla‐Solano Sandra , Fernández‐Portillo Antonio , Sánchez‐Escobedo Mari Cruz , Orden‐Cruz Carmen 
Published: September 2023

AbstractThis research aims to determine the effect of corporate social responsibility (CSR) disclosure on the firm performance (FP) of Spanish‐listed companies considering the mediation produced by the economic dimension. Using their sustainability reports, partial least squares structural equation modeling is employed for a content analysis. This study provides evidence on the mediating role of the disclosure of economic dimension practices and the intensity shown in the relationships between social and environmental dimensions and FP, allowing for a deeper understanding of the relationships between the various CSR dimensions. Findings show that the disclosure of social and environmental actions, aligned with appropriate standards in the economic dimension, can lead to an improvement in the FP of the company.
Conjoint belief adaption functionality for statistically secure communication paradigm for CR‐IIoTs
Authors: Indra Gaurav , Dhurandher Sanjay Kumar , Raj Richa 
Published: September 2023

SummaryIn an infrastructure‐critical manufacturing industry, continuous monitoring of the assembly lines with internet‐integrated sensors in an unforeseeable, stochastic, and harsh environment becomes indispensable for real‐time fault detection, location, and isolation. State‐of‐the‐art literature suggest that the Cognitive Radio‐based Industrial Internet of Things (CR‐IIoTs), a spectrum aware wireless communication paradigm, is best suited for monitoring as they are proficient in overcoming spectrum scarcity in a 2.4‐GHz industrial, scientific, and medical (ISM) band and guarantee a threshold Quality of Service (QoS) in hostile environs. Nonetheless, CR‐IIoTs and the Cognitive Radio‐based network archetype are susceptible to internal and external security threats at the application layer and vulnerable to Spectrum Sensing Data Falsification (SSDF) at Data Link Layer (DLL). In CR‐IIoTs, cooperative spectrum sensing (CSS) is a competent technique to ameliorate the performance of Primary User (PU) detection and optimizes the idle licensed spectrum bands access management. In this paper, a novel belief adaption framework in conjunction with an optimized secure communication scheme (termed as CBAF) based on the Certificateless‐Public Key Cryptography (CL‐PKC) is proposed for robust CSS in CR‐IIoTs. CBAF proficiently provides full‐Perfect Forward Secrecy, Ephemeral Secret Leakage‐Resilience, Public Key Replacement‐Resilience Malicious but Passive KGC‐Resilience, and Key Escrow Resilience. Simulation analysis pertaining to network performance indices ascertains the efficacy of CBAF, as it outperforms the state‐of‐the‐art in throughput, packet delivery ratio, and communication overhead by 8.5%, 6.7%, and 19.9% respectively. Under internal attacks, CBAF outperforms the best from state‐of‐the‐art by 11.3% in On‐Off attack, 19.7% in Data Tampering attack, 21.1% in SDF attack, and 13.4% in DDoS attack.
Identifying and detecting black hole and gray hole attack in MANET using gray wolf optimization
Authors: Vatambeti Ramesh , Supriya Kola Sangeetha , Sanshi Shridhar 
Published: September 2023

SummaryMobile ad hoc networks (MANETs) become most vibrant and are widely used in various applications, including military, commercial sectors, and personal area networks. However, security is a major issue in routing; because of moving nodes, mainly it suffers from a black hole and gray hole attack. This kind of attack is difficult to predict and is harmful to the network. To address this problem, here, we introduce the gray wolf optimization (GWO) with trust setup data aggregation called gray wolf trust accumulation in wireless ad hoc network architecture. To maintain and enhance the security in routing, here, we update the trust setup data aggregation in GWO mechanism. After the detection of black hole and gray hole attack, we need to maintain the path stability for data transmission, trust schematic process monitor all the nodes, and maintain path stability. Using the behavior of GWO, we can detect the black hole and gray hole attack at a rate of 98.5% and also improve the packet delivery ratio by 98.2% with 10 m/s. Also, with the help of the trust setup data aggregation model, we can update our trust model and security maintenance. Thus, our proposed technique enhances the packet transmission in MANET and secures the routing layer.
Optimal network restructure via improved whale optimization approach
Authors: Abd Elazim Sahar M. , Ali Ehab S. 
Published: September 2023

SummaryLatterly, reduction of power loss in distribution system is the objective of many researches due to its impact on total costs and voltage profiles. It can be handled by optimal restructure of radial distribution system (RDS). This article introduces an innovative approach to restructure of RDS by electing the optimal switches combination subject to the system operating constraints, which is improved whale optimization approach (IWOA). The suggested approach combines exploitation of WOA with exploration of differential evolution (DE), and thus, it supplies a promising candidate solution. The suggested approach is tested on IEEE 33 and 69 bus RDS. The superiority of the suggested approach compared with other well‐known approaches is verified through simulation results by observation of total losses, cost, and saving. Also, the impact of alterable loading is investigated to prove the effectiveness of the suggested IWOA.
Achieving balance between economic efficiency and user fairness in traffic rate management
Authors: Pan Lian , Wang Hanwu , Li Hexin 
Published: September 2023

SummaryThis paper studies achieving the desired balance between the resource economic efficiency and user fairness in network traffic rate allocation management. Fairness is a basic requirement of different competing traffic users, while maximizing the economic efficiency of traffic rate resource is desired by the network system resource provider. Hence, how to balance these two respects to achieve the desired trade‐off is a key challenging issue in real applications. Particularly, we propose a weight mechanism to specify the rate allocation weight ratio among different competing traffic users and also a trade‐off factor mechanism to clarify the extent of fairness compromise. To optimize the system rate resource economic efficiency, we formulate an objective optimization problem with consideration of both user weight diversity and fairness trade‐off as well. We also derive the balance curve, which shows the rate resource economic efficiency improved in relation to the extent of traffic user fairness trade‐off. The demonstration models are also constructed to implemented to implement both the trade‐off acceptable and unacceptable cases in practical traffic rate resource allocation applications.