bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceptability and operational feasibility of community health worker-led home phototherapy treatment for neonatal hyperbilirubinemia in rural Bangladesh
Authors: Jahan Farjana , Parvez Sarker Masud , Rahman Mahbubur , Billah Sk Masum , Yeasmin Farzana , Jahir Tania , Hasan Rezaul , Darmstadt Gary L. , Arifeen Shams El , Hoque Md. Mahbubul , Shahidullah Mohammod , Islam Muhammad Shariful , Ashrafee Sabina , Foote Eric M. 
Published: September 2023

Abstract
There is an unmet need for phototherapy treatment in low- and middle-income countries (LMICs) to prevent disability and death of newborns with neonatal hyperbilirubinemia. Home phototherapy deployed by community health workers (CHWs) in LMICs may help increase access to essential newborn postnatal care in a more acceptable way for families and lead to an increase in indicated treatment rates for newborns with hyperbilirubinemia. We aimed to investigate the operational feasibility and acceptability of a CHW-led home phototherapy intervention in a rural sub-district of Bangladesh for families and CHWs where home delivery was common and treatment facility for neonatal hyperbilirubinemia was often more than two hours from households. We enrolled 23 newborns who were > = 2 kilograms and > = 35 weeks’ gestational age, without clinical danger signs, and met the American Academy of Pediatric treatment criteria for phototherapy for hyperbilirubinemia. We employed a mixed-method investigation to evaluate the feasibility and acceptability of home phototherapy through surveys, in-depth interviews and focus group discussions with CHWs, mothers, and grandparents. Mothers and family members found home phototherapy worked well, saved them money, and was convenient and easy to operate. CHWs found it feasible to deploy home phototherapy and identified hands-on training, mHealth job aids, a manageable workload, and prenatal education as facilitating factors for implementation. Feasibility and acceptability concerns were limited amongst parents and included: a lack of confidence in CHWs’ skills, fear of putting newborn infants in a phototherapy device, and unreliable home power supply. CHW-led home phototherapy was acceptable to families and CHWs in rural Bangladesh. Further investigation should be done to determine the impact of home phototherapy on treatment rates and on preventing morbidity associated with neonatal hyperbilirubinemia. Clinical Trial (CT) registration ID: NCT03933423, full protocol can be accessed at https://gatesopenresearch.org/articles/7-58 Name of the trial registry: clinicaltrials.gov Clinical Trial (CT) registration Date: 01/05/2019
Impella RP Flex as a Rescue for the Failing Right Ventricle after Heart Transplantation
Authors: Agrawal Akanksha , Bommareddi Swaroop , Lozonschi Lucian , Dumitru Ioana , Shoemaker Joel 
Published: September 2023

Abstract
Right ventricular dysfunction (RVD) after orthotopic heart transplantation (OHT) is a common cause of morbidity and mortality in the early post-transplant phase. As its pathophysiology is multifactorial, management is challenging. Recently, Impella RP Flex was approved for RV support as a mechanical circulatory device. We hereby present the first case of its use in managing RV failure in a patient after OHT.
A Successful Live Birth Through In Vitro Fertilization and Embryo Transfer in Stage IVb Endometrial Carcinoma after Conservative Treatment: a Case Report
Authors: Xiao Zerui , Song Ziyi , Zhao Yuexin , Wang Yiqin , Li Xiaoping , Liang Rong , Wang Jianliu , lu Qun 
Published: September 2023

Abstract
Introduction
An increasing number of young patients with early-stage endometrial cancer are opting for fertility-sparing treatment, and they have achieved reassuring rates of complete remission, with some women achieving pregnancy. However, surgical treatment is still recommended for patients with advanced endometrial cancer. We reported a woman with IVb endometrial cancer (EC) who reached complete remission (CR) and gained a live birth successfully with the help of in vitro fertilization and embryo transfer (IVF-ET).
Case report
A 30-year-old woman found to have stage IVb EC after hysteroscopy, laparoscopy, and pathological examination. After a combination of chemotherapy and progesterone therapy, the woman achieved complete remission. The woman became pregnant with IVF-ET and got a full-term live birth. In addition, there was no recurrence after 19 months of observation. The molecular classification of POLE and the combination of chemotherapy and progesterone therapy may be associated with a good prognosis of this patient. The use of progestin-primed ovarian stimulation (PPOS) and the combination of letrozole and levonorgestrel-releasing intrauterine device (LNG-IUD) during ovulation induction seemed to be safe for the woman
Conclusion
This is the first report on fertility-sparing treatment and live birth for advanced EC. IVF-ET is feasible for women with EC who preserve reproductive function. The progestin-primed ovarian stimulation combined with levonorgestrel-releasing intrauterine device and letrozole seems to be safe for these women. Patients still need to be closely watched for tumor recurrence.
Immune-nutritional indexes for predicting the response to nivolumab immunotherapy in gastric cancer
Authors: Wada Yuma , Nishi Masaaki , Yoshikawa Kozo , Takasu Chie , Tokunaga Takuya , Nakao Toshihiro , Kashihara Hideya , Yoshimoto Toshiaki , Shimada Mitsuo 
Published: September 2023

Abstract
Background: Immune checkpoint inhibitors reportedly improve survival outcomes in patients with gastric cancer (GC). However, most patients develop disease progression, for which treatment options are limited. Although research has shown some benefits from nivolumab, accurate prediction of the response to nivolumab has not been achieved. We examined biomarkers for identification of patients with good response for promising treatment like immune checkpoint inhibitors.
Methods: We analyzed 40 patients with clinical unresectable or recurrent GC who received nivolumab immunotherapy and divided them into a responder group (n=7) and non-responder group (n=33) based on the RECIST criteria. We prioritized the following biomarkers: nutritional markers (prognostic nutritional index [PNI], lymphocyte-to-plasma C-reactive protein ratio [LCR], and neutrophil–lymphocyte ratio [NLR]), sarcopenia, and osteopenia.
Results: Our model predicted the response to nivolumab with excellent accuracy in immune-nutritional markers (LCR: area under the curve [AUC]=0.74, NLR: AUC=0.75, PNI: AUC=0.60), osteopenia (AUC=0.83), and sarcopenia (AUC=0.73). Moreover, the predictive accuracy of the risk-assessment model was superior to that of each parameter (AUC=0.93). The high-risk group based on the risk-assessment model was associated with poor overall survival (P<0.01) and progression-free survival (P=0.08). Moreover, univariate Cox proportional hazard regression analysis revealed that our model was an independent predictor of survival outcomes (hazard ratio=3.22, 95% confidence interval=1.62–6.42, P<0.01).
Conclusions: Measurement of nutritional markers, osteopenia, and sarcopenia allowed prediction of a response to nivolumab immunotherapy in patients with GC. Our novel risk-assessment model for predicting the response to nivolumab has potential for clinical translation.
Study on the difference of physical activities and static activities between urban and rural elderly and its influencing factors - Empirical Analysis Based on 2018 CLHLS Data
Authors: Song Keying , zhao Zijian 
Published: September 2023

Abstract
Using the data of CLHLS in 2018, the differences of physical activities, static activities and influencing factors between urban and rural elderly in China were studied.The results showed that there were still significant differences in physical activities and static activities between urban and rural elderly in China (p<0.001) and the proportion of urban and rural elderly people participating in static activities is significantly higher than the proportion of physical exercise (61.62% vs 34.91%, 51.52% vs 23.63%).After controlling factors such as population, socioeconomic, lifestyle, self-evaluation health and external support, the differences in physical exercise and static activities between urban and rural elderly are actually smaller than observed.Factors of
population, socioeconomic, lifestyle, self-assessment health and external support explain the differences.Not only that, some variables have different effects on physical activities and static activities.
Effects of different patterns of movement for correcting a deep curve of Spee with invisible orthodontic appliances on the anterior teeth: A finite element analysis
Authors: zhu lin , Liu Lin , Wang Wei , Deng WenWen 
Published: September 2023

Abstract
Objective
To evaluate the effects of five different patterns of mandibular molar movement and to define the most effective configuration to be implemented with clear aligners through finite element analysis.
Methods
A three-dimensional evaluation mandibular model with a deep overbite in the mandible was constructed based on cone beam computerized tomography (CBCT) data. The modelled components included mandibular dentition, mandibular periodontal ligaments, attachments, and aligners.
Results
Configuration A showed the highest distal displacement value, and configuration E showed the lowest value. For the central and lateral incisors, configuration E showed the highest PDL pressure. For canines, the difference between configurations C and D was not significant and the stress distribution differed among the five groups.
Conclusion
First, simultaneously, extruding the premolars during molar distalization could enhance the effectiveness of invisible aligners. Second, when expansion and extrusion are simultaneously performed during the distalization of teeth, attention must be given to the alveolar bone on the labial side of anterior teeth to prevent the occurrence of gingival recession, dehiscence, and fenestration.
Streptococcus suis serotype 2 collagenase-like protease promotes meningitis by increasing blood-brain barrier permeability
Authors: Mei Jikun , Jiang Xuan , Li Fengyang , Wu Zengshuai , Wu Tong , Zhu Junhui , Jiang Hexiang , Li Ziheng , Li Na , Lei Liancheng 
Published: September 2023

Abstract
Streptococcus suis serotype 2 (SS2) is an emerging zoonotic pathogen that causes meningitis in humans and pigs. It not only brings huge economic losses to the pig industry but also seriously threatens public health security. However, the mechanisms by which SS2 enters the brain and induces meningitis is not fully understood. Here, we investigated the role and mechanism of the SS2 collagenase-like protease (Clp) in promoting the passage of the bacterium across the blood-brain barrier (BBB). We found that SS2 Clp enhanced virulence and tissue colonization, and promoted the destruction of the BBB in mice. Compared with wild-type SS2, the ability of a Δclp mutant to cross human brain microvascular endothelial (hCMEC/D3) cell monolayers decreased, whereas the addition of recombinant protein rClp increased permeability. rClp also significantly promoted the adhesion of SS2 to hCMEC/D3, inhibited the expression of intercellular tight junction proteins ZO-1 and Occludin independent of its enzyme activity, and induced hCMEC/D3 apoptosis through the cell receptor ligand apoptosis and mitochondrial apoptosis pathways partly dependent on its enzyme activity, resulting in BBB destruction and increased permeability. Moreover, Clp increased macrophage (F4/80+), monocytes (F4/80-Ly6C+), and neutrophils (Ly6G+) infiltration into the brain after SS2 infection. Thus, SS2 Clp is required for the passage of the bacterium across the BBB, and the results, provide a theoretical basis for better prevention and treatment of SS2-induced meningitis.
The consequences of trade on global plastic pollution
Authors: Navarre Nicolas , Barbarossa Valerio , Tukker Arnold , Mogollón José 
Published: September 2023

Abstract
Plastic has become an omnipresent material that negatively affects ecosystems. Many high-income nations export plastic waste to alleviate local burdens, however importing countries have less advanced plastic treatment and management infrastructures. Here, we evaluate the influence of trade on global plastic leakage to the aquatic environment by combining spatial plastic waste generation with global plastic waste trade commodity data. Plastic waste traded from high-income and mismanaged in low- and middle-income countries results in 1.2 Mt of additional plastic debris accumulating in aquatic environments, increasing previous estimates of plastic pollution from high-income countries to freshwater environments by 51% and marine environments by 100%. Improving international cooperation is essential to stop this until now underestimated but crucial source of plastic waste polluting ecosystems worldwide.
Preliminary experiment into the effects of red ochre on decomposition rate and bone microstructure in stillborn/perinate Sus scrofa domesticus
Authors: Carlson Kellie Sara Duffett , Mandl Kirsten , Metscher Brian 
Published: September 2023

Abstract
The use of red ochre in funerary rituals holds continued interest for archaeologists and anthropologists given its ubiquity and debates surrounding its function. Despite this, and efforts into distinguishing corpse treatments on a histological level, there has been no experimental attempt to identify the potential effects of ochre treatments on soft tissue decomposition or skeletal remains. Moreover, there remain questions concerning the susceptibility of stillborn, perinate, and neonate remains to bacterial bioerosion. To help fill these knowledge gaps an exploratory study was conducted to assess the effects of red ochre on decomposition rate and bone histology using minimally destructive microCT-based protocols. Five stillborn or perinate domestic piglets, a reliable proxy for human corpse decomposition due to their similar gut bacteria and thoracic size, were either left untreated or subjected to one of two ochre treatments (paste or powder), and then buried or left to decompose in an open-air environment. The preliminary results of this experiment suggest that red ochre does not inhibit, nor significantly increase bacterial bioerosion in stillborn/perinate bone. However, ochre paste, which delayed skeletonisation and inhibited fly activity, did contribute to skeletal disarray in the exposed piglet, which we hypothesise is due to mechanical effects. Moreover, the very limited and localised evidence of potential bioerosion manifested on the periosteal surface, providing evidence for an exogenous origin for osteolytic microbiota.
DENND6A couples Arl8b to a Rab34/RILP/dynein complex regulating
retrograde lysosomal trafficking and autophagy
Authors: McPherson Peter , Kumar Rahul , Francis Vincent , Khan Maleeha , Aguila Adriana , Kulasekaran Gopinath 
Published: September 2023

Abstract
Lysosomes help maintain cellular proteostasis, and defects in lysosomal positioning and function lead to diseases including neurodegenerative disorders. The spatiotemporal distribution of lysosomes is regulated by small GTPases, including Rabs, which are activated by guanine nucleotide exchange factors (GEFs). DENN domain–bearing proteins are the largest family of Rab GEFs. Using a cell-based assay, we screened the DENN domain protein
family member DENND6A for potential GEF activity toward all 60 Rabs and identified 20 potential DENND6A substrates, including Rab34. Here, we demonstrate that DENND6A activates Rab34, which recruits a RILP/dynein complex to the lysosomes, promoting
lysosomal retrograde trafficking from the cell periphery to the minus ends of microtubules. Further, we identify DENND6A as an effector of Arl8b, a major regulatory GTPase on lysosomes. Initially known for promoting anterograde transport of lysosomes, Arl8b also facilitates lysosomal retrograde transport. We demonstrate that Arl8b recruits DENND6A to
peripheral lysosomes to activate Rab34 and initiate retrograde transport, regulating nutrient-dependent lysosomal juxtanuclear repositioning and loss of DENND6A impairs autophagic flux. Our findings support a model whereby Arl8b/DENND6A/Rab34-dependent lysosomal retrograde trafficking controls autophagy.
Observation of Non-Hermitian Skin Effect in Thermal Diffusion
Authors: Li Ying , Liu Yun-Kai , Cao Pei-Chao , Qi Minghong , Huang Qiang-Kai-Lai , Peng Yu-Gui , Zhu Xue-Feng 
Published: September 2023

Abstract
The paradigm shift of the Hermitian systems into the non-Hermitian regime profoundly modifies inherent property of the topological systems, leading to various unprecedented effects such as the non-Hermitian skin effect (NHSE). In the past decade, the NHSE effect has been demonstrated in quantum, optical and acoustic systems. Beside those wave systems, the NHSE in diffusive systems has not yet been observed, despite recent abundant advances in the study of topological thermal diffusion. Here, we design a thermal diffusion lattice based on a modified Su-Schrieffer-Heeger model and demonstrate the diffusive NHSE. In the proposed model, the asymmetric temperature field coupling inside each unit cell can be judiciously realized by appropriate configurations of structural parameters. The dynamic concentration feature of temperature field on the boundary regardless of initial excitation conditions can be clearly observed. We thus experimentally demonstrated the NHSE in thermal diffusion and verified its robustness against various defects. Our work provides a platform for exploration of non-Hermitian physics in the diffusive systems, which has important applications in efficient heat collection, highly sensitive thermal sensing and others.
Assessment of Maxillary Arch Form in Individuals With Unilateral and Bilateral Cleft Lip and Palate
Authors: Dogan Ege , Selver Ozdil , Doğan Servet , Boyacıoğlu Hayal 
Published: September 2023

Abstract
Objective
To analyze and compare maxillary arch forms in unilateral (UCLP), bilateral (BCLP) cleft lip and palate and control group patients
Materials and Methods
The research involved 450 patients (220 males, 230 females) aged 13 to 16, seeking orthodontic treatment at Ege University Orthodontics Department. Maxillary models of 150 UCLP, 150 BCLP, and 150 Angle Class I malocclusion (control) patients were evaluated for narrow, ovoid, and square forms using the 'OrthoForm-3M Unitek' template. Statistical analyses utilized IBM SPSS Statistics 25.0, employing a chi-square test to assess significance.
Results
Control group analysis showed ovoid arch form most common (51.7%), followed by narrow (32.2%) and square (16.1%). UCLP patients had most narrow form (37.3%), followed by ovoid (32.7%) and square (30%). BCLP patients had most square form (46.4%), followed by narrow (42.3%) and ovoid (11.3%). Significant differences in arc forms were found between UCLP/BCLP and control (p < 0.000). Cramer's V Test showed moderate correlation (Cramer's V = 0.265; p = 0.00). No gender differences were found (p = 0.879), and no arc form-gender correlation (p = 0.235).
Conclusion
Maxillary arch forms differ between UCLP and BCLP patients. UCLP patients commonly have narrow arch, while BCLP patients show square form. UCLP patients tend to have less square arch, BCLP patients less ovoid. In Angle Class I without CLP, ovoid is common, square least. The narrower maxillary arch form of CLP patients compared to those without CLP holds clinical importance, especially in treatment planning.
Clinical Relevance:
The importance of maxillary arch form in CLP treatment planning, as well as the potential impact on treatment outcomes
Hot Water Treatment – A physical strategy deployed in checking the Septoria leaf spot of tomato incited by Septoria lycopersici Speg.
Authors: Katoch Vijeta , Chandel Sunita 
Published: September 2023

Abstract
Septoria leaf spot (Septoria lycopersici Speg.) is the one of most serious foliar diseases of tomato. It mainly occurs on young leaves leading to severe defoliation which later proliferates in fruits and contributes towards detrimental yield losses. Considering the seed borne nature of pathogen, goal of present research was to eradicate the inoculum of disease from seeds by giving hot water treatment in vitro and evaluating its effect in vivo. Tomato seeds were subjected to hot water treatment (HWT) at temperature regimes 48, 50, 52 and 55°C at two different time intervals 15 and 30 minutes, amongst which HWT with 48°C at 30 minutes duration was found most effective in respect of increasing germination percentage (89.83%), seedling length (18.00cm), seedling vigour (1617.76), seedling dry weight (18.03mg) and minimum 4.19% seed infection. Under field condition also the same seeds treatment was found effective by giving reduction in the disease severity and incidence levels up to 47.01 and 33.26%, respectively. Next best temperature regime recorded was 50°C for 30 minutes which minimized the Septoria lycopersici seed infection with beneficial effect on seed growth parameters. Thus, present study come up with the new strategy to manage Septoria leaf spot by giving physical method of hot water as pre-treatment to tomato seeds that helped in reduction of disease spread and severity under field conditions, moreover improves the plant growth parameters and had a potential to substitute chemical fungicides.
Surgeon-Modified Fenestrated Endovascular Grafts and Thoracoscope-assisted Fixation for Treatment of Thoraco-abdominal Aortic Aneurysms
Authors: Wang Hong , Wang Wei , Wang Weifan , Liu Debin 
Published: September 2023

Abstract
Background Total endovascular technique with fenestrated endovascular graft might be hampered for the late dilatation of proximal landing zone, which may cause endografts migration. we describe a successful urgent hybrid procedure for extent III thoracoabdominal aortic aneurysm with aortic intramural hematoma.
Case Presentation A 55-year-old female with thoracoabdominal aortic aneurysm was considered at high surgical risk and unfit for open repair due to multiple comorbidities. Therefore, a hybrid procedure of surgeon-modified fenestrated endovascular graft combined with thoracoscope-assisted fixation was finally chosen and performed in the endovascular operating room. A 3-port technique was performed through a left video-assisted thoracoscopic approach. After the first tampering stent-graft was deployed, a double-needle suture was penetrated both the aortic wall and stent-graft to fix it on the top of thoracic aorta. Then the fenestrated endograft was introduced and oriented extracorporeally by rotating superior mesenteric artery and left renal artery fenestration radiopaque markers and deployed with perfect apposition between the fenestrations and target visceral artery. Each vessel was sequentially stented using Viabahn self-expandable stent to finish target vessel stenting. An Ankura cuff stent was deployed in the distal abdominal aortic artery.
Conclusion Surgeon-modified fenestrated endovascular graft combined with thoracoscope-assisted fixation may be an innovative and viable alternative for selected high-risk patients with extent III thoracoabdominal aortic aneurysm. A longer follow-up is needed to ascertain the success of this approach.