bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novelemm4 lineage associated with an upsurge in invasive group A streptococcal disease in the Netherlands, 2022
Authors: van der Putten Boas C.L. , Bril-Keijzers Wendy C.M. , Rümke Lidewij W. , Vestjens Stefan M.T. , Koster Linda A.M. , Willemsen Marloes , van Houten Marlies A. , Rots Nynke Y. , Vlaminckx Bart J.M. , de Gier Brechje , van Sorge Nina M. 
Published: January 2023

AbstractInvasive group A streptococcal (iGAS) disease cases increased in the first half year of 2022 in the Netherlands with a remarkably high proportion ofemm4 isolates. Whole-genome sequence analysis of 66emm4 isolates, 40 isolates from the pre-COVID-19-pandemic period 2009-2019 and 26 contemporary isolates from 2022, identified a novelStreptococcus pyogeneslineage (M4NL22), which accounted for 85%emm4 iGAS cases in 2022. Surprisingly, we detected few isolates of theemm4 hypervirulent clone, which has replaced nearly all otheremm4 in the USA and the UK. M4NL22displayed genetic differences compared to otheremm4 strains, although these were of unclear biological significance. In publicly available data, we identified a single Norwegian isolate belonging to M4NL22, which was sampled after the isolates from this study, possibly suggesting export of M4NL22to Norway. In conclusion, our study identified a novelS. pyogenes emm4 lineage underlying an increase of iGAS disease in early 2022 in the Netherlands and results have been promptly communicated with public health officials.Impact statementGroup AStreptococcus(predominantly comprisingStreptococcus pyogenes) has a long history of causing disease in humans. Over the past decades, researchers have described various changes in theS. pyogenespopulation circulating in humans. In this study, we describe a shift in theS. pyogenespopulation within typeemm4 in the Netherlands in early 2022. A novel lineage, which we termed M4NL22, became the predominantemm4 lineage during this period. This was surprising, as in other countries such as the USA and the UK, another recently emerged lineage became dominant. Our work informed public health officials on the possible causes of increasedS. pyogenescases in the Netherlands and underlines the added value of continued active bacteriological surveillance.Data summaryCode is freely available fromhttps://github.com/boasvdp/GAS_M4. All sequencing data is freely available from BioProject PRJEB58654.
Influence of Electronic Polarization on the Binding of Anions to a Chloride-Pumping Rhodopsin
Authors: Phan Linda X. , Chamorro Victor Cruces , Martinez-Seara Hector , Crain Jason , Sansom Mark S.P. , Tucker Stephen J. 
Published: January 2023

AbstractThe functional properties of some biological ion channels and membrane transport proteins are proposed to exploit anion-hydrophobic interactions. Here, we investigate a chloride-pumping rhodopsin (ClR) as an example of a membrane protein known to contain a defined anion binding site composed predominantly of hydrophobic residues. Using molecular dynamics simulations, we explore Cl−binding to this hydrophobic site and compare the dynamics arising when electronic polarization is neglected (CHARMM36 (c36) fixed-charge force field), included implicitly (via the prosECCo force field), or included explicitly (through the polarizable force field, AMOEBA). Free energy landscapes of Cl−moving out of the binding site and into bulk solution demonstrate that the inclusion of polarization results in stronger ion binding and a second metastable binding site in ClR. Simulations focused on this hydrophobic binding site also indicate longer binding durations and closer ion proximity when polarization is included. Furthermore, simulations reveal that Cl−within this binding site interacts with an adjacent loop to facilitate rebinding events that are not observed when polarization is neglected. These results demonstrate how the inclusion of polarization can influence the behavior of anions within protein binding sites and thereby reveal novel mechanisms.Statement of SignificanceMolecular simulations based on classical (Newtonian) mechanics represent the most common method of visualizing the behavior of water and ions within channels and nanopores. Although computationally efficient, many of the approximations required mean that these simulations often do not fully capture the complex and dynamic interactions involved. Here, we use the prosECCo force field that offers an improved electronic description whilst maintaining computational efficiency. We show that using this method to include the effects of polarization greatly influences the binding dynamics of anions to a protein binding site and yields results similar to more accurate but computationally demanding methods.
Label-free and non-destructive pathology of human lung adenocarcinomas with ultraviolet single-plane illumination microscopy
Authors: Zhang Yan , Huang Bingxin , Kang Lei , Tsang Victor T. C. , Wu Jiajie , Lo Claudia T. K. , Wong Terence T. W. 
Published: January 2023

AbstractLung cancer is one of the leading causes of cancer death worldwide. The diagnosis of lung cancer based on the analysis of formalin-fixed and paraffin-embedded (FFPE) tissues is laborious and time-consuming, failing to guide surgeons intraoperatively. Here we proposed a rapid histological imaging method, termed microscopy with ultraviolet single-plane illumination (MUSI), to enable rapidex-orin-vivoimaging of fresh and unprocessed tissues in a label-free and non-destructive manner. The MUSI system allows surgical specimens with large irregular surfaces to be screened at a speed of 0.5 mm2/s with a subcellular resolution, which is sufficient to provide immediate feedback to surgeons and pathologists for intraoperative decision-making. We demonstrate that MUSI can differentiate between different subtypes of human lung adenocarcinomas, revealing diagnostically important features that are comparable to the gold standard FFPE histology. As an assistive imaging platform, MUSI could facilitate the development of precise image-guided surgery and revolutionize the current practice in surgical pathology.
Individualistic attitudes in iterative Prisoner’s Dilemma undermine evolutionary fitness and may drive cooperative human players to extinction
Authors: Pulcu Erdem 
Published: January 2023

AbstractHumans perform inarguably the richest plethora of prosocial behaviors in the animal kingdom. Prosocial behaviors such as interpersonal cooperation and altruistic punishment are important for understanding how humans navigate their social environment. The success and failure of strategies human players device have implications for determining their long-term socio-economic/evolutionary fitness. Following the footsteps of Press and Dyson’s (2012), I implemented their evolutionary game theoretic models developed for the Iterated Prisoner’s Dilemma (a behavioral economic probe of interpersonal cooperation) and analysed human choice behavior in the Ultimatum Game (a behavioral economic probe of altruistic punishment) involving 50 human participants versus computerized opponents with prosocial or individualistic social value orientation. Although the results indicate that it is more likely to break cycles of mutual defection in ecosystems in which humans interact with individualistic opponents, analysis of social-economic fitness at the Markov stationary states suggested that this comes at an evolutionary cost. Overall, human players acted in a significantly more cooperative manner than their opponents, but they failed to overcome extortion from individualistic agents, risking “extinction” in 70% of the cases. These findings demonstrate human players might be short-sighted and social interactive decision strategies they device while adjusting to different types of opponents may not be optimal in the long run.
Career implications of career shocks through the lens of gender: the role of the academic career script
Authors: Van Helden Daphne Lisanne , Den Dulk Laura , Steijn Bram , Vernooij Meike Willemijn 
Published: January 2023

PurposeThe purpose of this explorative study is to investigate through the lens of gender the role of career shocks in career advancement experiences in academia. By taking a contextual approach, this study increases understanding of the role of the academic career script as a potential boundary for career shock implications.Design/methodology/approachThe authors studied career advancement experiences of a cohort of 75 men and women associate professors in the Netherlands via biographical interviews and conducted theoretically informed inductive analysis.FindingsThe analysis revealed the ambiguities and contradictions in the role of most career shocks in career advancement experiences. Failure to fit the majority of career shocks into the “rigid” academic career script generates discretionary latitude in handling shocks. These shocks pose unique barriers – and to a lesser extent unique benefits – to women's perceived opportunities for career advancement.Practical implicationsAcademic organizations should focus on cultivating more inclusive work environments with respect to career shocks. The 75 diverse biographies offer leverage to challenge traditional notions of academic career advancement.Originality/valueThis paper extends “structure and agency” literature on career building by showing how career shock implications are inherently contextual in the academic setting. Gendered support provisions for handling career shocks offer a novel explanation for the numerical minority of women in academic leadership.
The effect of entrepreneurial culture on innovation in a negative business environment: the case of Greece
Authors: Falaras Athanasios , Moschidis Odysseas 
Published: January 2023

PurposeThe aim of the paper is to study and propose a model of the effect of entrepreneurial culture on innovation, with the country's relevant institutional framework as a mediator. The model applies to the field of wine industry within the Greek institutional framework.Design/methodology/approachThe research population consists of wineries in Greece. A questionnaire was used to collect the data. Due to the fact that the model includes latent variables and indirect effects, the partial least squares (PLS) algorithm and the SMART-PLS software were chosen to analyze the data. The effect of entrepreneurial culture and institutional framework on innovation was examined as well as the role of institutional framework as a mediator.FindingsIt was found that entrepreneurial culture affects innovation positively and statistically significantly. What is more, it was found that the Greek institutional framework affects innovation negatively and statistically significantly. Finally, institutional framework negatively mediates between entrepreneurial culture and innovation, highlighted as a partial mediator.Practical implicationsIt is highlighted that it is up to entrepreneurs themselves to succeed. Furthermore, policymakers have to take the necessary measures to improve the external business environment of Greece. Indeed, entrepreneurship can succeed even further if the external environment is favorable.Originality/valueIt is interesting that despite the negative effect of institutional framework on innovation, the indirect positive effect of entrepreneurial culture on innovation is still statistically significant. This means that entrepreneurs who have the right mindset can overcome external barriers.
Promoting traditional ikat textiles: ethnographic perspectives on indigenous knowledge, cultural heritage preservation and ethnic identity
Authors: Chantamool Atcharee , Suttisa Choopug , Gatewongsa Thom , Jansaeng Apiradee , Rawarin Narongsak , Daovisan Hanvedes 
Published: January 2023

Purpose
This study aims to explore how indigenous knowledge, cultural heritage preservation and ethnic identity influence the production of traditional ikat textiles in northeast Thailand.

Design/methodology/approach
A qualitative research method used an ethnographic perspective with a realistic design. Purposive sampling was used to conduct 30 in-depth ethnographic interviews with members of Phu Thai ikat textile groups in Kalasin province. Interview transcripts were studied using thick descriptive analysis (themes, categorisation, coding and keywords).

Findings
The ethnographic study shows that natural dyeing, traditional crafts, materials, designs and patterns are used in Phu Thai ikat textile weaving. The results reveal that indigenous knowledge, cultural heritage preservation and ethnic identity are relevant to traditional ikat textiles.

Originality/value
To the best of the authors’ knowledge, this study uniquely focuses on a deeper theoretical understanding of indigenous knowledge and cultural heritage preservation, to sustain traditional ikat textiles.
Share pledging and earnings informativeness
Authors: Shi Xiangyan , Wang Juan , Ren Xiaoyi 
Published: January 2023

Purpose
The purpose of this paper is to investigate the effect of share pledging by controlling shareholders on earnings informativeness.

Design/methodology/approach
Using a sample of 23,120 firm-year observations from 2003 to 2019 in China, this paper examines how share pledging by controlling shareholders affects earnings informativeness, measured by earnings persistence and earnings response coefficients.

Findings
This paper finds that share pledging by controlling shareholders makes earnings less informative. The adverse impacts are more pronounced when share pledging distorts incentives of controlling shareholders to a greater extent and when the signaling of share pledging about a firm’s weak future performance is stronger. Finally, this paper further shows that the 2018 new regulation on share pledging effectively alleviates the negative impacts of share pledging on earnings informativeness.

Originality/value
First, this paper adds to the growing literature on the economic consequence of share pledging by documenting the adverse impacts of share pledging on earnings informativeness. The literature on the economic consequence of share pledging is often mixed, which justifies further research on the impacts of share pledging on earnings informativeness. Second, this paper documents a new signaling channel through which share pledging affects earnings informativeness. Third, the finding of this paper on the 2018 new regulation on share pledging may be interesting to research agencies, such as the Chartered Financial analyst institute and Institutional Shareholder Services institute that recommend tightening regulations on share pledging.
Trade liberalization and women empowerment in the Arab countries
Authors: Saqfalhait Nahil , AbdAlla Spetan Khawlah , Awad-Warrad Taleb , Alomari Mohammad W. 
Published: January 2023

PurposeThis paper investigates the impact of trade liberalization measured by trade openness (OPN) and tariffs on women empowerment measured by the gender gap index and gender development index, for two groups of Arab countries divided based on their income levels using annual data for the period 1995–2020. The study also considers other factors that may influence the gender gap, such as GDP growth and the female unemployment rate. The purpose of this paper is to address these issues and explorers whether the effects of trade liberalization differ based on the countries' income levels.Design/methodology/approachThis study employs the fully modified ordinary least squares (FM-OLS) regression model for heterogeneous cointegrated panels to examine the impact of trade liberalization on women empowerment. The study constructs an empirical two regression model of women empowerment measured by the gender gap model and gender development model for the two groups of higher-income countries and lower and middle-income countries.FindingsThe authors’ findings reveal that the impact of OPN on the gender gap varies between the two groups of Arab countries where more OPN within the higher-income group may increase the gender disparity, while it may reduce disparity within the lower and middle-income countries. In addition, GDP growth may reduce the gender disparity, while female unemployment raises the gender disparity between the two groups of countries in the long run. Findings also reveal that more OPN, tariffs and female unemployment may reduce gender development within the two groups, but more GDP growth may support the gender development in the long run.Originality/valueThis paper not only assesses the impact of trade liberalization on women empowerment generally, but also assess the women empowerment via two indices that are the gender gap and gender development in Arab countries which is – to the knowledge of the researchers – not yet investigated; further it explores if the effects of trade liberalization differs based on the countries' income levels.
Sustaining circular economy practices in supply chains during a global disruption
Authors: Dwivedi Ashish , Chowdhury Priyabrata , Paul Sanjoy Kumar , Agrawal Dindayal 
Published: January 2023

PurposeCircular economy (CE) practices are critical to achieving sustainable development goals. However, the recent global disruption caused by the COVID-19 pandemic has significantly impacted sustainable practices. The literature shows a significant research gap in analyzing factors that sustain CE practices in supply chains during a global disruption. This study fills the research gap by developing a mix-method approach to analyze factors for sustaining CE practices during a global disruption.Design/methodology/approachTo fulfill the objectives of this study, the list of factors that sustain CE practices was first identified by conducting a literature review and finalized through an expert opinion survey. The survey finalized 18 different factors for sustaining CE practices. The finalized factors were further analyzed using the grey decision-making trial and evaluation laboratory (DEMATEL) method. The quantitative analysis confirmed the priority of the factors and their cause-and-effect relationships.FindingsThe results revealed that continued stakeholder pressure, retention of CE and sustainability culture, continued implementation of cleaner technology, feedback system and ongoing CE training for resilience issues are the top five factors that sustain CE practices during a global disruption. The study also revealed ten factors as belonging to the cause group and eight to the effect group.Originality/valueThis study contributes to the literature by exploring factors for sustaining CE practices during a global disruption. Moreover, the study’s findings are important in real-life situations, as decision-makers can use the findings to formulate strategies for sustaining CE practices during future global disruptions.
Influence of hybrid nanoparticles on the wear behavior of aluminum alloy composites for aerospace applications
Authors: A. Santhosh Prakash , T. Parameshwaran Pillai 
Published: January 2023

Purpose
Engineers and scientists are searching for novel materials with high performance on all aspect points of view for the applications including marine, aero and automobile fields. AA8090 aluminum alloy is one of the materials used in aero industries for aircraft construction because of its weight reduction ability. However, the AA8090 alloy has a drawback such as low wear resistance that affects the life time of material; hence, it should be addressed. The purpose of this investigation is to improve the wear resistance of AA8090 alloy.

Design/methodology/approach
In this investigation, AA8090 aluminum alloy metal matrix composite was fabricated using different types of carbide nanoparticles such as vanadium carbide (VC), Cr3C2 and Mo2C by stir casting method and tribological and mechanical behaviors were studied.

Findings
Mechanical studies showed that the S1 sample displayed the maximum hardness of 142 HV and maximum tensile strength of 857 MPa because of the inclusion of hard VC particles. Tribological studies revealed that S1 sample showed high performance. A least wear rate of 0.003915 × 10–3 mm3/m was noted for S1 sample, which is 71% lower than the wear rate of S0 sample. Further, a least mass loss and lower coefficient of friction of 0.00152 g and 0.2, respectively, were observed for S1 sample because of its high hardness and high wear resistance because of the stuffing of high-hardness VC particles. Hence, it is concluded from this study that S1 sample, i.e. AA8090/VC, could be a better candidate for aerospace applications as it showed good tribological and mechanical properties.

Originality/value
To the best of the authors’ knowledge, this work is original and novel in the field of metal matrix composite which deals with the effect of hybridization on the wear performance of the aluminum alloy composites.
Cyberbullying in the workplace: a novel framework of routine activities and organizational control
Authors: Oguz Abdullah , Mehta Nikhil , Palvia Prashant 
Published: January 2023

PurposeThis study aims to develop a unified theoretical framework that presents a cohesive picture of workplace cyberbullying to better understand the interplay between cyberbullying, its effects on organizations and organizational controls enacted to contain these effects.Design/methodology/approachThe study conducts a theoretical review of the workplace cyberbullying literature between 2005 and 2021 drawing upon existing literature and two important theories, the routine activities theory and control theory. The final sample of 54 empirical papers represents a comprehensive body of literature on cyberbullying published across various disciplines.FindingsA theoretical model of workplace cyberbullying is developed, which highlights major antecedents to workplace cyberbullying and its impact on individual employees as well as organizations.Originality/valueAs firms increasingly rely on information and communication technologies (ICTs), the misuse of ICTs in the form of cyberbullying is also increasing. Workplace cyberbullying severely hurts an organization’s employees and compromises the efficacy of its information systems. Fortunately, various controls can be utilized by firms to minimize workplace cyberbullying and its attendant costs. In all, eleven propositions are offered, providing a robust agenda for future research. The authors also offer insights for practitioners on how to minimize cyberbullying in the workplace and its damaging effects.
Risk propagation and resilience in the agribusiness supply chain: a systematic literature review
Authors: Imbiri Soleman , Rameezdeen Raufdeen , Chileshe Nicholas , Statsenko Larissa 
Published: January 2023

PurposeThe purpose of this paper is to investigate risk propagation and resilience in the agribusiness supply chain (ASC).Design/methodology/approachThe paper undertakes a systematic literature review (SLR). Overall, 94 articles from six databases published between 2000 and 2022 underwent descriptive and thematic analysis.FindingsThere is a lack of research on risk propagation and resilience in the ASC for more than two decades. Accordingly, this research fills the gap in the extant literature by advancing the construct of risk propagation and resilience in the ASC and developing a framework proposing directions in risk propagation and resilience in ASC research.Research limitations/implicationsFirstly, only the Web of Science and Scopus databases were mostly used as primary sources while other databases were used as secondary sources to validate search results. Secondly, SLR is based on the peer-reviewed articles, books and conference papers; other non-academic sources relevant to the topic were not included in this paper.Originality/valueThe paper offers a set of constructs for understanding risk propagation and resilience in the ASC, develops a framework proposing directions in risk propagation and resilience in the ASC research and recommends three key themes for future research directions, namely, keep updated with recent constructs of risk propagation and resilience in the ASC, conduct case studies based on empirical studies to determine the current risk dependency and propagation in the ASC and conduct case studies based on empirical studies to determine resilience and sustainability in the ASC.