bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilizing a nomogram to predict the one-year postoperative mortality risk for geriatric patients with a hip fracture
Authors: Wu Cheng-Yi , Tsai Ching-Fang , Yang Hsin-Yi 
Published: July 2023

AbstractDespite the abundance of research on the risk factors for mortality following hip fracture surgery, there has been a dearth of studies on prediction models in this population. The objective of this research was to explore the influencing factors and construct a clinical nomogram to predict one-year postoperative mortality in patients with hip fracture surgeries. Using the Ditmanson Research Database (DRD), we included 2333 subjects, aged ≥ 50 years who underwent hip fracture surgery between October, 2008 and August, 2021. The endpoint was all-cause mortality. A least absolute shrinkage and selection operator (LASSO) derived Cox regression was performed to select the independent predictors of one-year postoperative mortality. A nomogram was built for predicting one-year postoperative mortality. The prognostic performance of nomogram was evaluated. On the basis of tertiary points in a nomogram, the patients were divided into low, middle and high risk groups, and compared by the Kaplan–Meier analysis. Within 1 year after hip fracture surgery, 274 patients (11.74%) died. Variables retained in the final model comprised age, sex, length of stay, RBC transfusions, hemoglobin, platelet, and eGFR. The AUC for one-year mortality predictions were 0.717 (95% CI = 0.685–0.749). The Kaplan–Meier curves were significantly different among the three risk groups (p < 0.001). The nomogram showed good calibration. In summary, we explored the one-year postoperative mortality risk in geriatric patients with a hip fracture and developed a prediction model that could help clinicians identify patients at high risk of postoperative mortality.
Reverse effect of home-use binaural beats brain stimulation
Authors: Klichowski Michal , Wicher Andrzej , Kruszwicka Agnieszka , Golebiewski Roman 
Published: July 2023

AbstractBinaural beats brain stimulation is a popular strategy for supporting home-use cognitive tasks. However, such home-use brain stimulation may be neutral to cognitive processes, and any intellectual improvement may be only a placebo effect. Thus, without belief in it, it may bring no benefits. Here we test 1000 individuals at their homes as they perform a two-part fluid intelligence test. Some took the second part listening to binaural beats, while others took it in silence or listening to other sounds. The binaural beats group was divided into three subgroups. The first one was informed that they would listen to sounds that improve the brain's work, the second that neutral sounds, and the third that some sounds the nature of which was not defined. We found that listening to binaural beats was not neutral, as it dramatically deteriorated the score irrespective of the condition. Silence or other sounds had no effect. Thus, home-use binaural beats brain stimulation brings reverse effects to those assumed: instead of supporting the effectiveness of cognitive activities, it may weaken them.
MicroRNA-146a negatively regulates inflammation via the IRAK1/TRAF6/NF-κB signaling pathway in dry eye
Authors: Han Ruifang , Gao Juan , Wang Liming , Hao Peng , Chen Xi , Wang Yuchuan , Jiang Zhixin , Jiang Li , Wang Ting , Zhu Lin , Li Xuan 
Published: July 2023

AbstractInflammation is a key factor in the pathogenesis of dry eye disease (DED). We aimed to investigate the role of microRNA-146a (miR-146a) in regulating corneal inflammation in a mouse model of benzalkonium chloride (BAC)-induced dry eye and the TNF-α-induced NF-κB signaling pathway in human corneal epithelial cells (HCECs). A mouse model of dry eye was established by administering with BAC to BALB/c mice, and the expression of TNF-α, IL-1β, IL-6, IL-8, cyclooxygenase 2 (COX2), interleukin-1 receptor-associated kinase 1 (IRAK1) and TNF receptor-associated factor 6 (TRAF6) in the corneas of dry eye model mice was significantly increased; this was accompanied by the upregulation of miR-146a and activation of the NF-κB pathway. In vitro, TNF-α induced miR-146a expression in HCECs, while the NF-κB inhibitor SC-514 reduced the expression of miR-146a. Overexpression of miR-146a decreased the expression of IRAK1 and TRAF6, which have been identified as targets of miR-146a. Furthermore, overexpression of miR-146a suppressed NF-κB p65 translocation from the cytoplasm to the nucleus. Moreover, overexpression of miR-146a attenuated the TNF-α-induced expression of IL-6, IL-8, COX2 and intercellular adhesion molecule 1 (ICAM1), while inhibition of miR-146a exerted the opposite effect. Our results suggest that miR-146a mediates the inflammatory response in DED. MiR-146a negatively regulates inflammation in HCECs through the IRAK1/TRAF6/NF-κB pathway, and this may serve as a potential therapeutic approach for the treatment of DED.
Avoidable heat-related mortality in China during the 21st century
Authors: Zhang Guwei , Sun Zhaobin , Han Ling , Iyakaremye Vedaste , Xu Zhiqi , Miao Shiguang , Tong Shilu 
Published: July 2023

AbstractUsing non-accidental mortality records from 195 sites and 11 model simulations from the Coupled Model Intercomparison Project phase 6, we assessed future avoidable heat-related deaths associated with emission mitigation after accounting for population changes in China. Without human-induced climate change in the 21st century, China’s heat-related mortality would drop by 48–72% (95% confidence interval (CI): 40–76%), especially at high latitudes and altitudes (up to 80%). Nationally, 15,576–87,612 (95% CI: 6605–106,736) heat-related deaths per year would potentially be avoided by reducing emissions. For most of China, temperature changes dominate the variation in heat-related deaths, while in Central and South China, population changes will have a greater influence. These not only reinforce the necessity of mitigating emissions but also suggest that adjusting population structure and spatial distribution could be applied in some areas to minimize warming impacts on public health. Notably, given that abatement will hardly bring immediate success within the next twenty years, more healthcare infrastructures are urgently needed to manage potential growing heat risks. Particularly in Northwest and South China, where future heat-related deaths would still be 110–140% of current levels (1995–2014) even without anthropogenic warming. We also found that without historical human-induced emissions, China’s low level of technology (medical and economic) might increase current heat-related mortality by 57%, even though warming could be mitigated. Consequently, we believe that mitigating climate change risks also requires consideration of the economic/medical losses from lowering emissions.
Global within-species phylogenetics of sewage microbes suggest that local adaptation shapes geographical bacterial clustering
Authors: Jespersen Marie Louise , Munk Patrick , Johansen Joachim , Kaas Rolf Sommer , Webel Henry , Vigre Håkan , Nielsen Henrik Bjørn , Rasmussen Simon , Aarestrup Frank M. 
Published: July 2023

AbstractMost investigations of geographical within-species differences are limited to focusing on a single species. Here, we investigate global differences for multiple bacterial species using a dataset of 757 metagenomics sewage samples from 101 countries worldwide. The within-species variations were determined by performing genome reconstructions, and the analyses were expanded by gene focused approaches. Applying these methods, we recovered 3353 near complete (NC) metagenome assembled genomes (MAGs) encompassing 1439 different MAG species and found that within-species genomic variation was in 36% of the investigated species (12/33) coherent with regional separation. Additionally, we found that variation of organelle genes correlated less with geography compared to metabolic and membrane genes, suggesting that the global differences of these species are caused by regional environmental selection rather than dissemination limitations. From the combination of the large and globally distributed dataset and in-depth analysis, we present a wide investigation of global within-species phylogeny of sewage bacteria. The global differences found here emphasize the need for worldwide data sets when making global conclusions.
Squaraine-linked zwitterionic COF modified LLZTO nanoparticles for high performance polymer composite electrolytes in Li–S batteries
Authors: Wang Shuo , Li Mengke , Yan Gaojie , Yang Zhipeng , Guo Yuchao , Sun Xi , Wang Yue , Feng Yi , Ding Huili , Zhang Xiaojie 
Published: July 2023

LLZTO@HUT4/PEO are employed as considerable PCEs in Li-S batteries, owing to modified lithiophobic interface by zwitterionic COF, which promote Li+ transport, suppress shuttle effect and improve the compatibility of inorganic/organic interface.
Bi3+/Sm3+ co-doped LiTaO3 photochromic perovskites: an ultrafast erasable optical information storage medium
Authors: Zhang Ruiting , Jin Yahong , Li Yanmei , Wu Haoyi , Hu Yihua 
Published: July 2023

LiTaO3:Bi3+/Sm3+ materials exhibit reversible color changes under different wavelength light irradiation, and have an ultra fast photobleaching rate of ~1 s.
Endocannabinoid signaling and epigenetics modifications in the neurobiology of stress-related disorders
Authors: Coelho Arthur A. , Lima-Bastos Sávio , Gobira Pedro H. , Lisboa Sabrina F. 
Published: July 2023

Abstract
Stress exposure is associated with psychiatric conditions, such as depression, anxiety, and post-traumatic stress disorder (PTSD). It is also a vulnerability factor to developing or reinstating substance use disorder. Stress causes several changes in the neuro-immune-endocrine axis, potentially resulting in prolonged dysfunction and diseases. Changes in several transmitters, including serotonin, dopamine, glutamate, gamma-aminobutyric acid (GABA), glucocorticoids, and cytokines, are associated with psychiatric disorders or behavioral alterations in preclinical studies. Complex and interacting mechanisms make it very difficult to understand the physiopathology of psychiatry conditions; therefore, studying regulatory mechanisms that impact these alterations is a good approach. In the last decades, the impact of stress on biology through epigenetic markers, which directly impact gene expression, is under intense investigation; these mechanisms are associated with behavioral alterations in animal models after stress or drug exposure, for example. The endocannabinoid (eCB) system modulates stress response, reward circuits, and other physiological functions, including hypothalamus–pituitary–adrenal axis activation and immune response. eCBs, for example, act retrogradely at presynaptic neurons, limiting the release of neurotransmitters, a mechanism implicated in the antidepressant and anxiolytic effects after stress. Epigenetic mechanisms can impact the expression of eCB system molecules, which in turn can regulate epigenetic mechanisms. This review will present evidence of how the eCB system and epigenetic mechanisms interact and the consequences of this interaction in modulating behavioral changes after stress exposure in preclinical studies or psychiatric conditions. Moreover, evidence that correlates the involvement of the eCB system and epigenetic mechanisms in drug abuse contexts will be discussed.
A BER formula of OTFS modulation with message‐passing receiver
Authors: Du Peng , Zhang Yuan 
Published: July 2023

AbstractThe orthogonal time frequency space (OTFS) modulation is a promising multicarrier waveform which can have good performance in high‐mobility scenarios. Among various receivers designed for the OTFS modulation, the message‐passing (MP) receiver has received much attention which can achieve a good bit error rate (BER) performance. However, the BER performance of MP receiver is usually obtained through simulations due to the lack of corresponding BER formula in the literature. This work studies the BER formula of OTFS modulation with MP receiver over doubly selective fading channel. Specifically, equivalent signal models of the MP receiver are first defined and the expression of the corresponding signal‐noise‐ratio (SNR) is derived, then the probability distribution function of the SNR is estimated by assuming the distribution of SNR as a lognormal distribution, then the methods to estimate the parameters of the distribution function are proposed, and finally the formula for calculating the BER of the OTFS modulation with MP receiver is obtained. Simulation results verify that the proposed BER formula is accurate.
Model predictive torque control for permanent magnet synchronous motor with hybrid mode duty cycle optimization
Authors: Chen Jundong , He Shaojia , Huang Qian 
Published: July 2023

AbstractDue to the application of only one voltage vector in a control period, conventional model predictive torque control (MPTC) suffers from relatively large steady‐state ripples. The‐state‐of‐the‐art double‐vector‐based MPTC (DVMPTC) was proposed to improve steady‐state performance. However, its duty cycle optimization method significantly affects the control performances. Thus, MPTC with hybrid mode duty cycle optimization is proposed, which realizes better performance than the universal DVMPTC, and obtains the appropriate average switching frequency, especially at high‐speed domain. The proposed method utilises the universal DVMPTC method, while it equips duty cycle optimization with discrete space vector modulation (DSVM) scheme as the additional constraint for further reducing the reference voltage tracking error that exists in DVMPTC. What's more, rotation module and pre‐selection strategies are involved in simplifying the design of vector selection methods. Comparative simulations and experiments verify the effectiveness of the proposed method.
Cascaded face super‐resolution with shape and identity priors
Authors: Zeng Dan , Li Zelin , Yan Xiao , Jiang Wen , Wang Xinshao , Liu Jiang , Tang Bo 
Published: July 2023

AbstractDespite impressive progress in face super‐resolution (SR), it is an open challenge to reconstruct a reliable SR face that preserves authentic facial characteristics. Here, the problem of super‐resolving low‐resolution (LR) faces to high‐resolution (HR) ones is addressed. To tackle the ill‐posed nature of face SR, the cascaded super‐resolution network (CSRNet) is proposed to utilize shape and identity priors jointly and progressively, the first to explore multiple priors. Specifically, CSRNet adopts a cascaded structure to transform an LR face to HR face progressively via multiple stages. At each stage, CSRNet forces its output face image to match both the shape priors and identity priors extracted from the ground‐truth HR face. The shape priors estimated in one stage are merged into the inputs of its subsequent stage to provide rich information for the face SR. To generate realistic yet discriminative faces, the cascaded super‐resolution generative adversarial network (CSRGAN) is also proposed to incorporate the adversarial loss and identification loss into CSRNet. Extensive experiments on popular benchmarks show that the CSRNet and CSRGAN outperform existing face SR state‐of‐the‐art methods, both quantitatively and qualitatively, and detailed ablation studies show the advantage of this method.
Surface‐coated polymer nanocomposites containing z‐aligned high‐k nanowires as high‐performance dielectrics at elevated temperatures
Authors: Cheng Sang , Yang Mingcong , Fu Jing , Wang Rui , He Jinliang , Li Qi 
Published: July 2023

AbstractRecently, demands for high‐performance polymer film capacitors at elevated temperatures have become more urgent. High dielectric constant is essential for dielectric materials to achieve substantial energy density at relatively low electric fields, which is of great significance to practical applications, while improving the permittivity of high‐temperature polymer dielectrics without a remarkable deterioration in other electrical properties still remains a challenge. Here, a polymer nanocomposite containing z‐aligned high‐k nanowires sandwiched by e‐beam evaporation deposited Al2O3 films was developed based on the optimal structure proposed by the phase‐field simulation. It is found that z‐aligned nanowires are more effective in promoting the dielectric constant than random‐aligned ones, and a large increase in dielectric constant is observed at relatively low content of nanofillers. Outer insulating layers effectively suppress the electric conduction and improve the breakdown strength. Consequently, the nanocomposite with only 1 volume fraction of z‐aligned nanowires exhibits a breakdown strength, electrical resistance, and charge–discharge efficiency as high as neat PEI, but more than twice the discharged energy density than it at 150 °C. This study realises the optimal structure predicted by simulation in experiment, obtaining high‐permittivity, high‐temperature nanocomposites at no expense of other electrical properties, and making it possible to achieve high discharged energy density at relatively low electric fields.
Deploying cloud‐native experimental platforms for zero‐touch management 5G and beyond networks
Authors: Barrachina‐Muñoz Sergio , Nikbakht Rasoul , Baranda Jorge , Payaró Miquel , Mangues‐Bafalluy Josep , Kokkinos Panagiotis , Soumplis Polyzois , Kretsis Aristotelis , Varvarigos Emmanouel 
Published: July 2023

AbstractAn experimental framework for managing 5G and beyond networks through cloud‐native deployments and end‐to‐end monitoring is presented. The framework uses containerised network functions in a Kubernetes cluster across a multi‐domain network spanning cloud and edge hosts. End‐to‐end monitoring is demonstrated through Grafana dashboards that showcase both infrastructure resources and radio metrics in two scenarios involving UPF re‐selection and user mobility. As a third scenario, the authors demonstrate how a decision engine interacts with the experimental platform to perform zero‐touch containerised application relocation, highlighting the potential for enabling dynamic and intelligent management of 5G networks and beyond.
An optical digital‐to‐analog converter with a built‐in intensity converter consisting of silicon waveguide
Authors: Aikawa Yohei , Uenohara Hiroyuki 
Published: July 2023

AbstractOptical digital‐to‐analog converters (DACs) are key to overcoming the enormous power consumption caused by the slowdown of Moore's Law. In previous work, an optical DAC consisting of a signal generator and an intensity converter was presented. The generating component was integrated into the device, but a higher level of device integration is desirable. An optical DAC device with a built‐in intensity converter for a 2‐bit binary phase‐shift keying (BPSK) signal is demonstrated. The integrated device consists of two delay line interferometers (DLIs) with silicon waveguides. The first is used to generate a quadrature PSK (QPSK) signal from two BPSK signals, and the second is used to convert the QPSK constellation into light intensities. Experimental results show that the 2‐bit digital codes 00, 01, 10, and 11 can be successfully converted into four different light intensities depending on their pattern at 10 Gbps.
Protamine dose to neutralize heparin at the completion of cardiopulmonary bypass can be reduced significantly without affecting post-operative bleeding
Authors: Lee Min-Ho , Beck Matthew , Shann Kenneth 
Published: July 2023

Background: Systemic anticoagulation with heparin during cardiopulmonary bypass (CPB) should be neutralized by protamine administration to restore normal hemostasis. Our previous study showed the protamine-to-heparin ratio (P-to-H) of 1:1 (1 mg protamine:100 IU circulating heparin; 1.0 Ratio) is likely an overestimation. Thus, we reduced the P-to-H in the HMS Plus Hemostasis Management System to 0.9:1 (0.9 Ratio) for 5 months and then to 0.8:1 (0.8 Ratio). We monitored post-operative (post-op) bleeding in the setting of reduced protamine dose (PD). Methods: We performed a retrospective study of 632 patients (209 for the 1.0 Ratio, 211 for 0.9 Ratio, 212 for 0.8 Ratio group) who underwent cardiac surgery to measure the reduction of PD and how it affects 24-hour (24 h) post-op chest tube output. We also analyzed the entire data set to explore whether further reduction of P-to-H is warranted. Results: While there was no difference in the indexed heparin dose among the three groups, we achieved a significant reduction in the indexed actual protamine dose (APDi) by 24% (0.9 Ratio) and 31% (0.8 Ratio) reductions compared to the 1.0 Ratio group. On average, APDi was 88 ± 22, 67 ± 18, and 61 ± 15 mg/m2 in the 1.0, 0.9, and 0.8 Ratio groups, respectively. We found no significant difference in 24 h post-op bleeding among the three groups. Conclusion: 1.0 Ratio at the completion of CPB is likely an excessive administration of protamine. With the stepwise reduction of PD, we observed no increase in post-op bleeding, which may indicate that no meaningful increase in heparin rebound occurred. In addition, further analysis of the entire data set demonstrates that a 0.75 Ratio is likely sufficient to neutralize the heparin completely.
Brillouin laser spectrometer based on spectral compression
Authors: Murray Joseph B. , Murray Matthew J. , Redding Brandon 
Published: July 2023

We introduce a spectrometer design that uses Brillouin lasing to perform broadband spectral compression. This approach enables the entire C-band (optical frequencies covering 4 THz, or 25 nm) to be compressed into a 230 MHz wide RF spectrum—allowing a 4 THz wide optical spectrum to be monitored continuously using a standard analog-to-digital converter. This technique is based on the linear dependence of the Brillouin frequency shift on optical wavelength. To use this dependence for spectral analysis, we couple the input optical spectrum into a fiber ring cavity where it acts as an optical pump, exciting a frequency-shifted Brillouin lasing spectrum. The Brillouin lasing spectrum is then referenced to a copy of the original optical spectrum using heterodyne detection, converting the Brillouin frequency shift associated with each lasing mode to the RF domain. The narrow linewidth of the lasing modes enables a precise measurement of individual lines with an uncertainty of 28 MHz (0.2 pm) across a 4 THz band at an update rate of 200 Hz. This simple approach, constructed using standard fiber-coupled telecom components, provides an efficient method for high-resolution, broadband spectral analysis.