bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pneumonia risk prediction in patients with acute alcohol withdrawal syndrome through evaluation of sarcopenia index as a prognostic factor
Authors: Zhao Lingdan , Huang Sha , Jing Fu , Yu Ting-ting , Wei Zeng , Chen Xiaoyan 
Published: February 2023

Abstract
Objective
This study aimed to explore the relationship between the sarcopenia index (SI) and the risk of pneumonia in hospitalized patients with acute alcohol withdrawal syndrome (AWS).

Study design
We have performed a retrospective study of individuals with AWS from a teaching hospital in western China. Patients' data were retrieved from the medicinal record databases. Patients' primary (upon admission) blood serum creatinine (Cr) and cystatin C (CysC) levels were incorporated into the records. Participants were separated into low and high SI cohorts based on the three-quarter digit of SI (SI = serum Cr/serum CysC ratio × 100). The association between SI and the risk of pneumonia in hospitalized patients with AWS was assessed by logistic regression analysis.

Result
Three hundred and twelve patients with acute AWS were included in this retrospective analysis. Among hospitalized patients with acute AWS, the incidence of pneumonia was 13.78%. The average median age of acute AWS patients with pneumonia was 55.28 (10.65) years, and the mean age of acute AWS individuals without pneumonia was 51.23 (10.08) years. In the univariate analysis, the high SI group (SI > 87.91) had a lower incidence of pneumonia than the low SI group (SI ≤ 87.91) (high SI vs. low SI, 6.41% vs. 16.24%, p = 0.029). Further logistic regression analysis showed that the high SI group demonstrated a poorer risk of pneumonia (OR = 0.353, 95%CI: 0.134–0.932, p = 0.036). After adjusting for possible confounders, the risk of pneumonia remained low in the high SI group (OR = 0.358, 95%CI: 0.132–0.968, p = 0.043).

Conclusion
Our results showed that SI was linked with the risk of pneumonia in hospitalized individuals with acute AWS. We further suggest that it could be a pneumonia risk factor, especially in medical centers where sarcopenia diagnosis is unavailable.
Detection rates of abnormalities in over 10,000 amniotic fluid samples at a single laboratory
Authors: Lu Sha , Kakongoma Nisile , Hu Wen-sheng , Zhang Yan-zhen , Yang Nan-nan , Zhang Wen , Mao Ai-fen , Liang Yi , Zhang Zhi-fen 
Published: February 2023

Abstract
Background
A growing number of cytogenetic techniques have been used for prenatal diagnosis. This study aimed to demonstrate the usefulness of karyotyping, BACs-on-Beads (BoBs) assay and single nucleotide polymorphism (SNP) array in prenatal diagnosis during the second trimester based on our laboratory experience.

Methods
A total of 10,580 pregnant women with a variety of indications for amniocentesis were enrolled in this retrospective study between January 2015 and December 2020, of whom amniotic fluid samples were analysed in 10,320 women. The main technical indicators of participants in the three different technologies were summarized, and cases of chromosome abnormalities were further evaluated.

Results
The overall abnormality detection rate of karyotyping among all the amniotic fluid samples was 15.4%, and trisomy 21 was the most common abnormality (20.9%). The total abnormality detection rate of the BoBs assay was 5.6%, and the diagnosis rate of microdeletion/microduplication syndromes that were not identified by karyotyping was 0.2%. The detection results of the BoBs assay were 100.0% concordant with karyotyping analysis in common aneuploidies. Seventy (87.5%) cases of structural abnormalities were missed by BoBs assay. The total abnormality detection rate of the SNP array was 21.6%. The detection results of common aneuploidies were exactly the same between SNP array and karyotyping. Overall, 60.1% of structural abnormalities were missed by SNP array. The further detection rate of pathogenic significant copy number variations (CNVs) by SNP was 1.4%.

Conclusions
Karyotyping analysis combined with BoBs assay or SNP array for prenatal diagnosis could provide quick and accurate results. Combined use of the technologies, especially with SNP array, improved the diagnostic yield and interpretation of the results, which contributes to genetic counselling. BoBs assay or SNP array could be a useful supplement to karyotyping.
Association between outpatient follow-up and incidence of revision after knee and hip replacements: a population-based cohort study
Authors: Pinedo-Villanueva Rafael , Kolovos Spyros , Burn Edward , Delmestri Antonella , Smith Lindsay K. , Judge Andrew , Kingsbury Sarah R. , Stone Martin H. , Conaghan Philip G. 
Published: February 2023

Abstract
Background
Follow-up visits 5 or 7 years after surgery were recommended for people having primary hip or knee replacement. The benefits of this practice to patients and the healthcare system, however, have not yet been specifically examined. The aim of this study was to investigate the association between long-term follow-up outpatient hospital visits and revision rates for patients who undergo primary knee or hip replacement surgery.

Methods
Cohorts were identified for patients undergoing knee or hip replacement surgery using medical records from primary care practices within the UK Clinical Practice Research Datalink (CPRD) GOLD dataset linked to hospital records from the English Hospital Episodes Statistics (HES) data. Two groups of patients were compared in terms of revision and mortality rates: those with at least one long-term (between five and 10 years since primary surgery) follow-up visit at the orthopaedic department (‘Follow-up’ group), and those without (‘No follow-up’ group).

Results
A total of 9856 (4349 in the Follow-up group) patients with knee replacement and 10,837 (4870 in the Follow-up group) with hip replacement were included in the analysis. For knee replacement, the incidence of revision was 3.6% for those followed-up and 0.6% for those not followed-up. An adjusted regression model confirmed the difference in the hazard ratio (HR) for revision was statistically significant (HR: 5.65 [95% CI 3.62 to 8.81]). Mortality at 4 years was lower for the Follow-up (17%) compared to the No follow-up group (21%), but this difference was not statistically significant (HR: 0.95 [0.84 to 1.07]). For hip replacement, the incidence of revision rates were 3.2 and 1.4% for the follow-up and not follow-up groups, respectively, the difference being statistically significant (HR: 2.34 [1.71 to 3.20]). Mortality was lower for the Follow-up (15%) compared to the No follow-up group (21%), but the difference was not statistically significant (HR: 0.91 [0.81 to 1.02]).

Conclusion
Patients attending follow-up orthopaedic consultations show a higher risk of revision surgery compared to those who are not followed-up. A cause for this difference could not be identified in this study but a likely explanation is that surgeons play an effective role as ultimate arbitrators when identifying patients to be included in long-term follow-up lists.
Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies
Authors: Stinson Rebecca J. , Morice Alyn H. , Sadofsky Laura R. 
Published: February 2023

Abstract
Background
Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, including Rhinovirus (hRV), Adenovirus, Respiratory Syncytial Virus (RSV), Coronavirus and Influenza, there is no single and effective treatment. Over-the-counter (OTC) remedies, including traditional medicines and those containing plant derived substances, help to alleviate symptoms including inflammation, pain, fever and cough.

Purpose
This systematic review focuses on the role of the major plant derived substances in several OTC remedies used to treat cold symptoms, with a particular focus on the transient receptor potential (TRP) channels involved in pain and cough.

Methods
Literature searches were done using Pubmed and Web of Science, with no date limitations, using the principles of the PRISMA statement. The search terms used were ‘TRP channel AND plant compound’, ‘cough AND plant compound’, ‘cough AND TRP channels AND plant compound’, ‘cough AND P2X3 AND plant compound’ and ‘P2X3 AND plant compound’ where plant compound represents menthol or camphor or eucalyptus or turpentine or thymol.

Results
The literature reviewed showed that menthol activates TRPM8 and may inhibit respiratory reflexes reducing irritation and cough. Menthol has a bimodal action on TRPA1, but inhibition may have an analgesic effect. Eucalyptus also activates TRPM8 and inhibits TRPA1 whilst down regulating P2X3, aiding in the reduction of cough, pain and airway irritation. Camphor inhibits TRPA1 and the activation of TRPM8 may add to the effects of menthol. Activation of TRPV1 by camphor, may also have an analgesic effect.

Conclusions
The literature suggests that these plant derived substances have multifaceted actions and can interact with the TRP ‘cough’ receptors. The plant derived substances used in cough and cold medicines have the potential to target multiple symptoms experienced during a cold.
N-terminal pro–B-type natriuretic peptide levels in normotensive and hypertensive dogs with myxomatous mitral valve disease stage B
Authors: Jang In Sung , Yoon Won Kyoung , Choi Eun Wha 
Published: February 2023

Abstract
Background
Systemic hypertension affects the heart, and to the best of our knowledge, no study has investigated the effects of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in dogs with myxomatous mitral valve disease (MMVD) stage B and systemic hypertension. This study aimed to investigate the blood level of NT-proBNP and assess the selected echocardiographic variables in dogs with MMVD stage B according to the presence of systemic hypertension or normal blood pressure and in dogs without MMVD.

Results
The study group comprised 37 dogs with stage B MMVD (normotensive group, n = 30; systemic hypertension group, n = 7) and 13 dogs without MMVD. We evaluated NT-proBNP, blood pressure, complete blood count (CBC), and serum chemistry in all 50 dogs. We performed electrocardiography, radiography, and echocardiography on 44 dogs (37 dogs with MMVD and 7 dogs without MMVD). The NT-proBNP concentrations showed significant intergroup differences (p < 0.001). Normotensive dogs with MMVD stage B (median [interquartile range]: 1083.5 [574.8–1912.8] pmol/L) and hypertensive dogs with MMVD stage B (2345.0 [1812.5–2533.0] pmol/L) showed significantly higher NT-proBNP concentrations than dogs without MMVD (504 [430–774] pmol/L, p = 0.009 and p < 0.001, respectively), and dogs in the systemic hypertension group showed significantly higher NT-proBNP concentrations than those in the normotensive group (p = 0.046). Mitral valve regurgitation velocity was significantly higher in dogs in the systemic hypertension group (6.11 [6.07–6.24] m/s) than in those in the normotensive group (5.53 [5.17–5.95] m/s, p = 0.006). The left atrial to aortic root ratio (LA/Ao), E-peak velocity, and left ventricular end‐diastolic internal diameter corrected for body weight (LVIDDN) were significantly lower in dogs without MMVD than in dogs with MMVD stage B.

Conclusions
These findings suggest that NT-proBNP concentrations are higher in dogs with MMVD stage B with systemic hypertension than in normotensive dogs with MMVD stage B. Therefore, clinicians should be aware that NT-proBNP could be elevated in the presence of systemic hypertension.
Nonorthogonal waveform assisted DOA estimation for joint MIMO sensing and communication
Authors: Lin Luning , Zheng Hang , Zhou Chengwei , He Shibo , Shi Zhiguo 
Published: February 2023

AbstractConventional direction-of-arrival (DOA) estimation methods for multiple-input multiple-output (MIMO) joint sensing and communication system normally pursue high estimation accuracy and resolution by imposing orthogonal waveforms. However, such operation results in a deterioration of communication performance. In this paper, we propose a nonorthogonal waveform assisted DOA estimation algorithm, where an augmented virtual array is derived by exploiting the nonorthogonal MIMO communication waveforms, while a high communication rate can still be maintained. To estimate the round-trip sensing channels of each subcarrier, we utilize the transmitted symbols as pilot symbols, and obtain all the channel coefficients with a minimum mean square error solver. A virtual channel matrix can be formulated with these channel coefficients, which can be regarded as the samples of an augmented virtual array. Based on that, the subspace processing can be conducted for DOA estimation with fully nonorthogonal waveforms. Furthermore, the rank deficiency property of the equivalent signal matrix of the virtual array is analyzed when the distance of targets are identical. To address the problem, a Toeplitz reconstruction method is proposed to restore the rank of the rank-deficient equivalent signal matrix for DOA estimation. Simulations show that the proposed nonorthogonal waveform assisted DOA estimation algorithm outperforms the conventional methods in terms of resolution and accuracy, while maintaining a satisfactory computational efficiency.
Application of IMMF–IHHT algorithm to suppressing random interference of geomagnetic sensors
Authors: Zhang Ping-an , Gao Min , Wang Wei , Wang Yi , Su Xu-jun 
Published: February 2023

AbstractAiming at the problem that the geomagnetic sensor is vulnerable to external interference in the navigation process, this paper analyzes the frequency distribution range of geomagnetic signal and the noise characteristics in geomagnetic signal and proposes an improved morphological filtering and Hilbert–Huang transform (IMMF–IHHT) algorithm to extract and recognize the features of geomagnetic measurement signal. To avoid frequency aliasing and distortion caused by empirical mode decomposition, an improved morphological filtering algorithm based on mean constraint is used to preprocess the measured signal. The Hilbert spectrum of the decomposed signal is solved, the signal components are discriminated by the similarity criterion, and the signal components in line with the frequency range of the geomagnetic signal are extracted and processed to reconstruct the geomagnetic measurement signal. Simulation and experiments show that the signal-to-noise ratio and root-mean-square error of IMMF–IHHT combination algorithm are better than MF-HHT combination algorithm and IHHT algorithm. This algorithm has good signal feature extraction and recognition ability.
Electrochemical study of agarose hydrogels for natural convection on macroelectrodes and ultramicroelectrodes
Authors: Han Jihun , Jang Sukman , Kim Byung-Kwon , Park Kyungsoon 
Published: February 2023

AbstractElectrochemical measurements using an agarose hydrogel as a solid electrolyte and ferrocyanide as a redox probe were conducted to analyze transport properties and natural convection effects. The mass transport properties and diffusion coefficients of ferrocyanide were studied using various macroelectrodes and ultramicroelectrodes via cyclic voltammetry. The experimental results confirmed that the mass transfer behavior in agarose was similar to that in solution. The good linearity of the square root of the scan-rate-dependent peak current demonstrated that diffusion is dominant during mass transfer in agarose hydrogel owing to a reduction in other mass transport effects (i.e., migration and convection). Furthermore, chronoamperometry (CA) was performed to estimate the effects of natural convection in the solution and agarose hydrogel. CA curves and plots of current as a function of the inverse square root of time yielded irregular and irreproducible responses in the solution for relatively long-term electrochemistry. However, in the agarose hydrogel, the CA response was more regular and reproducible for > 300 s because of reduced natural convection, based on the Cottrell’s theory.
Effects of Platelet-Rich Plasma in Tear Size Reduction in Partial-Thickness Tear of the Supraspinatus Tendon Compared to Corticosteroids Injection
Authors: Tanpowpong Thanathep , Thepsoparn Marvin , Numkarunarunrote Numphung , Itthipanichpong Thun , Limskul Danaithep , Thanphraisan Phark 
Published: February 2023

Abstract
Objectives
Corticosteroid (CS) injection is commonly used in partial-thickness rotator cuff tears to decrease pain. However, this could result in unwanted side effects, such as tendon rupture. Alternatively, platelet-rich plasma (PRP) injection is frequently used to treat tendinopathies because it enhances healing. This study aimed to compare the differences in tear size and functional scores between intralesional PRP and subacromial CS injections.

Methods
Patients with symptomatic partial-thickness tears of the supraspinatus tendon who underwent conservative treatment for ≥ 3 months were enrolled. All patients underwent magnetic resonance imaging (MRI) to confirm the diagnosis. Fourteen and 15 patients were randomized to receive intralesional PRP and subacromial CS injections, respectively. Tears were measured in the coronal and sagittal planes. The patients underwent another MRI 6 months after the injection. Tear size was compared between the two MRI results. The American Shoulder and Elbow Surgeons Shoulder score (ASES) and Constant–Murley score (CMS) were also obtained.

Results
The baseline data were similar between the groups. In the coronal plane, PRP and CS showed tear size reductions of 3.39 mm (P = 0.003) and 1.10 mm (P = 0.18), respectively. In the sagittal plane, PRP and CS showed tear size reductions of 2.97 mm (P = 0.001) and 0.76 mm (P = 0.29), respectively. Functional scores improved 6 months after injection in both groups, but PRP showed better functional scores than CS (P = 0.002 for ASES, P = 0.02 for CS).

Conclusion
Intralesional PRP injection can reduce the tear size in partial-thickness tears of the supraspinatus tendon. Subacromial steroid injection did not significantly affect the tear size. While CS improved functional scores compared with baseline, PRP resulted in better improvement 6 months post-injection.
Trial registration Thai Clinical Trials Registry, TCTR20210428004. Registered 28 April 2021-retrospectively registered, TCTR20210428004.
In vitro evaluation of the herbal cream formulation from methanolic leaf extracts of Tephrosia vogelii Hook.f for topical application
Authors: Mlozi Stephano Hanolo , Mmongoyo Juma A. , Chacha Musa N. 
Published: February 2023

Abstract
Background
Topical infectious are among of global challenges which propelled up with antimicrobial resistances. This scenario compels for drug discovery and development. Herbal formulation is one of important struggle in the drug development with the purpose of overcoming various diseases distressing health care settings. Thus, this study aimed to formulate and evaluate herbal cream from leaf methanolic extracts of Tephrosia vogelii Hook.f for topical therapies.

Methods
Herbal cream was prepared by homogeneously mixing up cream base and methanolic leaf extracts of Tephrosia vogelii. Physicochemical properties and in vitro antimicrobial activities of the cream were evaluated. The stability, colour change, washability and texture were parameters used evaluate physicochemical properties of cream. Disc diffusion method was employed to evaluate antimicrobial activities of the cream against Candida albicans (ATCC 90,028), Escherichia coli (ATCC29953) and Staphylococcus aureus (ATCC25923).

Results
Formulated herbal creams; CBTV1, CBTV2 and CBTV3 with methanolic extracts concentrations content of Tephrosia vogelii 0.05%, 0.10% and 0.25%, respectively, were prepared. All cream formulations were stable, washable by water, green in colour and soft. The CBTV3 product exhibited with high prominent antimicrobial activity compared to the rest, henceforth promisingly to be effective for topical skin therapy.

Conclusion
The herbal cream formulation of methanolic leaf extract of Tephrosia vogelii at 0.25% appeared to have more antimicrobial performance. Therefore, it is considered as minimal concentration for the herbal cream formulation in future for clinical trials as a potential antifungal and antibacterial agent product for treatment of skin infections.

Graphical Abstract
Take a load off: examining partial and complete cognitive offloading of medication information
Authors: Richmond Lauren L. , Kearley Julia , Schwartz Shawn T. , Hargis Mary B. 
Published: February 2023

AbstractAlthough cognitive offloading, or the use of physical action to reduce internal cognitive demands, is a commonly used strategy in everyday life, relatively little is known about the conditions that encourage offloading and the memorial consequences of different offloading strategies for performance. Much of the extant work in this domain has focused on laboratory-based tasks consisting of word lists, letter strings, or numerical stimuli and thus makes little contact with real-world scenarios under which engaging in cognitive offloading might be likely. Accordingly, the current work examines offloading choice behavior and potential benefits afforded by offloading health-related information. Experiment 1 tests for internal memory performance for different pieces of missing medication interaction information. Experiment 2 tests internal memory and offloading under full offloading and partial offloading instructions for interaction outcomes that are relatively low severity (e.g., sweating). Experiment 3 extends Experiment 2 by testing offloading behavior and benefit in low-severity, medium-severity (e.g., backache), and high-severity interaction outcomes (e.g., heart attack). Here, we aimed to elucidate the potential benefits afforded by partial offloading and to examine whether there appears to be a preference for choosing to offload (i) difficult-to-remember information across outcomes that vary in severity, as well as (ii) information from more severe interaction outcomes. Results suggest that partial offloading benefits performance compared to relying on internal memory alone, but full offloading is more beneficial to performance than partial offloading.
Multimodal learning analytics of collaborative patterns during pair programming in higher education
Authors: Xu Weiqi , Wu Yajuan , Ouyang Fan 
Published: February 2023

AbstractPair programming (PP), as a mode of collaborative problem solving (CPS) in computer programming education, asks two students work in a pair to co-construct knowledge and solve problems. Considering the complex multimodality of pair programming caused by students’ discourses, behaviors, and socio-emotions, it is of critical importance to examine their collaborative patterns from a holistic, multimodal, dynamic perspective. But there is a lack of research investigating the collaborative patterns generated by the multimodality. This research applied multimodal learning analytics (MMLA) to collect 19 undergraduate student pairs’ multimodal process and products data to examine different collaborative patterns based on the quantitative, structural, and transitional characteristics. The results revealed four collaborative patterns (i.e., a consensus-achieved pattern, an argumentation-driven pattern, an individual-oriented pattern, and a trial-and-error pattern), associated with different levels of process and summative performances. Theoretical, pedagogical, and analytical implications were provided to guide the future research and practice.