bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long noncoding RNA 02027 inhibits proliferation, migration and invasion of hepatocellular carcinoma via miR‐625‐3p/PDLIM5 pathway
Authors: Wang Jinyi , Zhu Yong , Ai Xiaoming , Wan Hong , Jia Wenbo , Chu Jian , Xu Bin , Kong Xiangxu , Kong Lianbao 
Published: February 2023

AbstractBackgroundLong non‐coding RNAs have been established to promote or inhibit the oncogenic and tumorigenic potential of various cancers, acting as competing endogenous RNAs (ceRNAs) for specific microRNAs. The primary objective of the study was to investigate the underlying mechanism by which the LINC02027/miR‐625‐3p/PDLIM5 axis affects proliferation, migration and invasion in hepatocellular carcinoma (HCC).MethodsThe differentially expressed gene was selected based on gene sequencing and bioinformation database analysis of HCC and adjacent non‐tumor tissues. The expression of LINC02027 in HCC tissues and cells and its regulatory effect on the development of HCC were detected by colony formation, cell counting kit‐8 assays, wound healing assays, Transwell assays and subcutaneous tumorigenesis assays in nude mice. According to the results of database prediction, quantitative real‐time polymerase chain reaction and dual‐luciferase reporter assay, the downstream microRNA and target gene were searched. Finally, HCC cells were transfected with lentivirus and used for cell function assays in vitro and in vivo.ResultsDownregulation of LINC02027 was detected in HCC tissues and cell lines and was associated with poor prognosis. The overexpression of LINC02027 suppressed the proliferation, migration and invasion of HCC cells. Mechanistically, LINC02027 inhibited epithelial‐to‐mesenchymal transition. As a ceRNA, LINC02027 inhibited the malignant ability of HCC by competitively binding to miR‐625‐3p to regulate the expression of PDLIM5.ConclusionsThe LINC02027/miR‐625‐3p/PDLIM5 axis inhibits the development of HCC.
Association of 48‐h net fluid status with change in renal function and dyspnea among patients with decompensated heart failure: A pooled cohort analysis of three acute heart failure trials
Authors: Chen Alyssa Y. , Kannan Subhasri , Chu Eugene S. , Sumarsono Andrew 
Published: February 2023

AbstractBackgroundAcute heart failure (AHF) exacerbations are a leading cause of hospitalization in the United States. Despite the frequency of AHF hospitalizations, there are inadequate data or practice guidelines on how quickly diuresis should be achieved.ObjectiveTo study the association of 48‐h net fluid change and (A) 72‐h change in creatinine and (B) 72‐h change in dyspnea among patients with acute heart failure.Designs, Settings, and ParticipantsThis is a retrospective, pooled cohort analysis of patients from the DOSE, ROSE, and ATHENA‐HF trials.InterventionsThe primary exposure was 48‐h net fluid status.Main Outcomes and MeasuresThe co‐primary outcomes were 72‐h change in creatinine and 72‐h change in dyspnea. The secondary outcome was risk of 60‐day mortality or rehospitalization.ResultsEight hundred and seven patients were included. The mean 48‐h net fluid status was −2.9 L. A nonlinear association was observed with net fluid status and creatinine change, such that creatinine improved with each liter net negative up to 3.5 L (−0.03 mg/dL per liter negative [95% confidence interval [CI]: −0.06 to −0.01) and remained stable beyond 3.5 L (−0.01 [95% CI: −0.02 to 0.001], p = .17). Net fluid loss was associated with a monotonic improvement of dyspnea (1.4‐point improvement per liter negative [95% CI: 0.7–2.2], p = .0002). Each liter net negative by 48 h was also associated with 12% decreased odds of 60‐day rehospitalization or death (odds ratio: 0.88; 95% CI: 0.82–0.95; p = .002).ConclusionAggressive net fluid targets within the first 48 h are associated with effective relief of patient self‐reported dyspnea and improved long‐term outcomes without adversely affecting renal function.
Establishing the linkage between eba's instrumental and sensory descriptive profiles and their correlation with consumer preferences: implications for cassava breeding
Authors: Emmanuel Alamu Oladeji , Teeken Béla , Ayetigbo Oluwatoyin , Adesokan Michael , Kayondo Ismail , Chijioke Ugo , Madu Tessy , Okoye Benjamin , Abolore Bello , Njoku Damian , Rabbi Ismail , Egesi Chiedozie , Ndjouenkeu Robert , Bouniol Alexandre , De Sousa Kauê , Dufour Dominique , Maziya‐Dixon Busie 
Published: February 2023

AbstractBACKGROUNDGari and eba, forms of cassava semolina, are mainly consumed in Nigeria and other West African countries. This study aimed to define the critical quality traits of gari and eba, to measure their heritability, to define medium and high throughput instrumental methods for use by breeders, and to link the traits with consumer preferences. The definition of a food product's profiles, including its biophysical, sensory, and textural qualities, and the identification of the characteristics that determine its acceptability, are important if new genotypes are to be adopted successfully.RESULTSEighty cassava genotypes and varieties (three different sets) from the International Institute of Tropical Agriculture (IITA) research farm were used for the study. Participatory processing and consumer testing data on different types of gari and eba products were integrated to prioritize the traits preferred by processors and consumers. The color, sensory, and instrumental textural properties of these products were determined using standard analytical methods, and standard operating protocols (SOPs) developed by the RTBfoods project (Breeding Roots, Tubers, and Banana Products for End‐user Preferences, https://rtbfoods.cirad.fr). There were significant (P < 0.05) correlations between instrumental hardness and sensory hardness and between adhesiveness and sensory moldability. Principal component analysis showed broad discrimination amongst the cassava genotypes and the association of the genotypes concerning the color and textural properties.CONCLUSIONSThe color properties of gari and eba, together with instrumental measures of hardness and cohesiveness, are important quantitative discriminants of cassava genotypes. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The Interaction Effect of 27‐Hydroxycholesterol Metabolism Disorder and CYP27A1 Single Nucleotide Polymorphisms in Mild Cognitive Impairment: Evidence from a Case–Control Study
Authors: Wang Lijing , Yu Huiyan , Hao Ling , Ju Mengwei , Feng Wenjing , Xiao Rong 
Published: February 2023

ScopeThe aim of the study is to investigate the relationship between 27‐hydroxycholesterol (27‐OHC), 27‐hydroxylase (CYP27A1) polymorphisms, and Alzheimer's disease (AD).Methods and resultsA case–control study based on EMCOA study includes 220 healthy cognition and mild cognitive impairment (MCI) subjects respectively, matched by sex, age, and education. The level of 27‐OHC and its related metabolites are examined by high performance liquid chromatography–mass spectrometry (HPLC−MS). The results show that 27‐OHC level is positively associated with risk of MCI (p < 0.001), negatively associated with specific domain of cognitive function. Serum 27‐OHC is positively associated with 7a‐hydroxy‐3‐oxo‐4‐cholestenoic acid (7‐HOCA) in cognitive healthy subjects, while positively associated with 3β‐hydroxy‐5‐cholestenoic acid (27‐CA) in MCI subjects (p < 0.001). CYP27A1 and Apolipoprotein E (ApoE) single nucleotide polymorphisms (SNPs) genotyping are determined. The global cognitive function is significant higher in Del‐carrier of rs10713583, compared with AA genotype (p = 0.007). Stroop Color‐Word Test Interference Trial (SCWT‐IT) is significant higher in G‐carrier genotype (p = 0.042), compared with TT genotype in rs12614206.ConclusionsThe results show that 27‐OHC metabolic disorder is associated with MCI and multi‐domain cognitive function. CYP27A1 SNPs is correlated to cognitive function, while the interaction between 27‐OHC and CYP27A1 SNPs need further study.
Bunkering and information decisions in the sea cargo service industry based on uncertain spot price
Authors: Song Zhuzhu , Xu Man , Chen Pingping 
Published: February 2023

AbstractThe pursuit of lower costs and the volatility of spot prices force shipping companies to sign fuel supply contracts with suppliers in advance. Meanwhile, suppliers that take on price risks typically seek further information on spot market prices. Furthermore, they need to consider whether to share the information with shipping companies as such information can affect shipping companies' decision on speed and, hence, their fuel consumption and shipper business. To study the refueling and information issues of the shipping supply chain, we describe a game between a shipping company and a supplier on the basis of a fuel supply contract. Results show that compared with the case without information sharing, the case with information sharing with a possibly lower spot price can bring higher profits for the shipping company and supplier. At this point, the shipping company will increase its navigation speed and benefit from the resulting increase in shipper business. Meanwhile, the supplier can benefit from the shipping company's increased fuel consumption. The supplier decides to share information with the shipping company before receiving signals only when the prediction accuracy is high, indicating that the supplier's prediction motivation is to sway the shipping company's risk assessment. Restricted by prediction costs, the supplier will not improve the prediction accuracy indefinitely, but such improvement can always benefit the shipping company. Hence, information prediction can be a win‐win strategy for the shipping company and supplier.
Asymptotics for the eigenvalues of Toeplitz matrices with a symbol having a power singularity
Authors: Bogoya Manuel , Grudsky Sergei M. 
Published: February 2023

AbstractThe present work is devoted to the construction of an asymptotic expansion for the eigenvalues of a Toeplitz matrix as goes to infinity, with a continuous and real‐valued symbol having a power singularity of degree with , at one point. The resulting matrix is dense and its entries decrease slowly to zero when moving away from the main diagonal, we apply the so called
simple‐loop
(SL) method for constructing and justifying a uniform asymptotic expansion for all the eigenvalues. Note however, that the considered symbol does not fully satisfy the conditions imposed in previous works, but only in a small neighborhood of the singularity point. In the present work: (i) We construct and justify the asymptotic formulas of the SL method for the eigenvalues with , where the eigenvalues are arranged in nondecreasing order and is a sufficiently small fixed number. (ii) We show, with the help of numerical calculations, that the obtained formulas give good approximations in the case . (iii) We numerically show that the main term of the asymptotics for eigenvalues with , formally obtained from the formulas of the SL method, coincides with the main term of the asymptotics constructed and justified in the classical works of Widom and Parter.
Assessment of electroencephalography modification by antipsychotic drugs in patients with schizophrenia spectrum disorders using frontier orbital theory: A preliminary study
Authors: Ozaki Takashi , Mikami Koichiro , Toyomaki Atsuhito , Hashimoto Naoki , Ito Yoichi M. , Kusumi Ichiro 
Published: February 2023

AbstractAimSchizophrenia is characterized by an abnormality in electroencephalography (EEG), which can be affected by antipsychotic drugs. Recently, the mechanism underlying these EEG alterations in schizophrenia patients was reframed from the perspective of redox abnormalities. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) can be calculated using a computational method and may be useful for evaluating the antioxidant/prooxidant effect of antipsychotic drugs. Thus, we examined the association between the effects of antipsychotic monotherapy on quantitative EEG and HOMO/LUMO energy.MethodsWe used medical report data including EEG results of psychiatric patients admitted to Hokkaido University Hospital. We extracted the EEG records of patients diagnosed with a schizophrenia spectrum disorder undergoing antipsychotic monotherapy during the natural course of treatment (n = 37). We evaluated the HOMO/LUMO energy of all antipsychotic drugs using computational methods. Multiple regression analyses were used to examine the relationship between the HOMO/LUMO energy of all antipsychotic drugs and spectral band power in all patients. Statistical significance was set at p < 6.25 × 10−4 adjusted with Bonferroni correction.ResultsWe showed that the HOMO energy of all antipsychotic drugs had weak positive correlations with delta‐ and gamma‐band power (e.g., standardized β = 0.617 for delta in the F3 channel, p = 6.6 × 10−5; standardized β = 0.563 for gamma in the O1 channel, p = 5.0 × 10−4).ConclusionAlthough there may be unexpected bias and confounding factors, our findings suggest that the effect of antipsychotic drugs on EEG may be related to their antioxidant actions.
Glucagon‐like peptide‐1 agonists combined with sodium‐glucose cotransporter‐2 inhibitors reduce weight in type 1 diabetes
Authors: Al‐Ozairi Ebaa , Irshad Mohammad , Taghadom Etab , Sojan Litty , Al Kandari Jumana , Alroudhan Dherar , le Roux Carel W. 
Published: February 2023

AbstractObjectiveThis study evaluated whether adding sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) and/or glucagon‐like peptide‐1 receptor agonists (GLP1‐RA) to insulin reduced weight and glycemia in people with type 1 diabetes.MethodsThis retrospective analysis of electronic health records evaluated 296 people with type 1 diabetes over 12 months after medications were first prescribed. Four groups were defined: controln = 80, SGLT2in = 94, GLP1‐RAn = 82, and combination of drugs (Combo)n = 40. We measured changes at 1 year in weight and glycated hemoglobin (HbA1c).ResultsThe control group did not have changes in weight or glycemic control. The mean (SD) percentage weight loss after 12 months was 4.4% (6.0%), 8.2%  (8.5%), and 9.0% (8.4%) in the SGLT2i, GLP1‐RA, and Combo groups, respectively (p < 0.001). The Combo group lost the most weight (p < 0.001). The HbA1c reduction was 0.4%  (0.7%), 0.3% (0.7%), and 0.6% (0.8%) in the SGLT2i, GLP1‐RA, and Combo groups, respectively (p < 0.001). The Combo group had the biggest improvements in glycemic control and total and low‐density lipoprotein cholesterol compared with baseline (allp < 0.01). Severe adverse events were similar between all the groups, with no increased risk of diabetic ketoacidosis.ConclusionsThe SGLT2i and GLP1‐RA agents on their own improved body weight and glycemia, but combining the medications resulted in more weight loss. Treatment intensification appears to result in benefits with no difference in severe adverse events.
Birthweight of children with isolated congenital heart disease—A sibling analysis study
Authors: Aliasi Moska , Mastenbroek Malou , Papakosta Styliani , van Geloven Nan , Haak Monique C. 
Published: February 2023

AbstractObjectiveCongenital heart disease (CHD) is associated with decreased birthweight (BW) compared to population‐based references. The aim of this study was to compare the BW of isolated CHD cases to their siblings, thus controlling for unknown and unmeasured confounders within the family.MethodsAll isolated CHD cases in the Leiden University Medical Center were included (2002–2019). Generalized estimated equation models were constructed to compare BW z scores of CHD neonates with their siblings. Cases were clustered to minor or severe CHD and stratified according to the aortic flow and oxygenation to the brain.ResultsThe overall BW z score of siblings was 0.032 (n = 471). The BW z score was significantly lower in CHD cases (n = 291) compared to their siblings (−0.20, p = 0.005). The results were consistent in the subgroup analysis of severe and minor CHD (BW z score difference −0.20 and −0.10), but did not differ significantly (p = 0.63). Stratified analysis regarding flow and oxygenation showed no BW difference between the groups (p = 0.1).ConclusionIsolated CHD cases display a significantly lower BW z score compared to their siblings. As the siblings of these CHD cases show a BW distribution similar to the general population, this suggests that shared environmental and maternal influences between siblings do not explain the difference in BW.
Mechanistic in vitro studies indicate that the clinical drug–drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3
Authors: Elsby Robert , Coghlan Hannah , Edgerton Jacob , Hodgson David , Outteridge Samuel , Atkinson Hayley 
Published: February 2023

AbstractPrevious use of a mechanistic static model to accurately quantify the increased rosuvastatin exposure due to drug–drug interaction (DDI) with coadministered atazanavir underpredicted the magnitude of area under the plasma concentration–time curve ratio (AUCR) based on inhibition of breast cancer resistance protein (BCRP) and organic anion transporting polypeptide (OATP) 1B1. To reconcile the disconnect between predicted and clinical AUCR, atazanavir and other protease inhibitors (darunavir, lopinavir and ritonavir) were evaluated as inhibitors of BCRP, OATP1B1, OATP1B3, sodium taurocholate cotransporting polypeptide (NTCP) and organic anion transporter (OAT) 3. None of the drugs inhibited OAT3, nor did darunavir and ritonavir inhibit OATP1B3 or NTCP. All drugs inhibited BCRP‐mediated estrone 3‐sulfate transport or OATP1B1‐mediated estradiol 17β‐D‐glucuronide transport with the same rank order of inhibitory potency (lopinavir>ritonavir>atazanavir>>darunavir) and mean IC50 values ranging from 15.5 ± 2.80 μM to 143 ± 14.7 μM or 0.220 ± 0.0655 μM to 9.53 ± 2.50 μM, respectively. Atazanavir and lopinavir also inhibited OATP1B3‐ or NTCP‐mediated transport with a mean IC50 of 1.86 ± 0.500 μM or 65.6 ± 10.7 μM and 5.04 ± 0.0950 μM or 20.3 ± 2.13 μM, respectively. Following integration of a combined hepatic transport component into the previous mechanistic static model using the in vitro inhibitory kinetic parameters determined above for atazanavir, the newly predicted rosuvastatin AUCR reconciled with the clinically observed AUCR confirming additional minor involvement of OATP1B3 and NTCP inhibition in its DDI. The predictions for the other protease inhibitors confirmed inhibition of intestinal BCRP and hepatic OATP1B1 as the principal pathways involved in their clinical DDI with rosuvastatin.
Sarcoidosis presenting as optic neuritis with vision loss
Authors: Kataoka Ryosuke , Kai Yoshiro , Ohara Hiroya , Hirai Hiromasa , Suzuki Kentaro , Takano Masato , Yamamoto Yoshifumi , Muro Shigeo 
Published: February 2023

AbstractNeurosarcoidosis is a rare complication of sarcoidosis and unusually presents as optic neuritis. We present the case of a 51‐year‐old man who complained of right vision loss. Brain magnetic resonance imaging showed asymmetrical enlargement of the right optic nerve. Chest computed tomography detected mediastinal and hilar lymphadenopathy. There were cutaneous nodules on the back. Biopsy of the mediastinal lymph node by endobronchial ultrasound‐guided transbronchial needle aspiration and the skin showed noncaseating granulomas consistent with sarcoidosis. Serum angiotensin‐converting enzyme level was elevated (34.2 IU/L) (normal: 8.3–21.4 IU/L). Based on these findings, he was diagnosed as neurosarcoidosis with optic neuritis. He was started on 1000‐mg/day methylprednisolone intravenously for 3 days, followed by oral 50‐mg/day prednisolone, which was gradually tapered for 8 weeks. Thereafter, the skin nodules and lymphadenopathy decreased and the right vision partially improved. Based on this rare case, sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.
Buckley–Jamesestimation of generalized additive accelerated lifetime model with ultrahigh‐dimensional data
Authors: Li Zichang , Zhao Xuejing 
Published: February 2023

AbstractHigh‐dimensional covariates in lifetime data is a challenge in survival analysis, especially in gene expression profile. The objective of this paper is to propose an efficient algorithm to extend the generalized additive model to survival data with high‐dimensional covariates. The algorithm is combined of generalized additive (GAM) model and Buckley–James estimation, which makes a nonparametric extension to the nonlinear model, where the GAM is exploited to illustrate the nonlinear effect of the covariates and the Buckley–James estimation is used to address the regression model with right‐censored response. In addition, we use maximal‐information‐coefficient (MIC)‐type variable screening and weightedp‐value to reduce dimension in high‐dimensional situations. The performance of the proposed algorithm is compared with the three benchmark models: Cox proportional hazards regression model, random survival forest, and BJ‐AFT on a simulated dataset and two real survival datasets. The results, evaluated by concordance index (C‐index) as well as modified mean squared error (mMSE), illustrated the superiority of the proposed algorithm.
Refugee caregivers: Associations between psychosocial wellbeing and parenting in Uganda
Authors: Meinhart Melissa , Mangen Patrick Onyango , Hermosilla Sabrina , Cohen Flora , Agaba Gary Samuel , Kajungu Rehema , Knox Justin , Obalim Grace , Stark Lindsay 
Published: February 2023

AbstractCaregivers in humanitarian settings experience compounding stressors that may challenge their ability to provide quality parenting to children in their care. In recognition of this precarity, our analysis examines the linkage between psychosocial wellbeing and parenting behaviours among caregivers in Kiryandongo Settlement, Uganda. Using baseline data from an evaluation of a psychosocial intervention designed to support caregiver wellbeing and engage caregivers to support children in their communities, multi‐variable ordinary least square regressions were used to estimate how various measures of psychosocial wellbeing (i.e. psychological distress, social support, and functioning) and parenting attitudes (related to violence against children) are associated with parental warmth and rejection. Profound livelihood challenges were found, as nearly half of the sample (48.20%) indicated cash from INGOs as their income source and/or reported never attending school (46.71%). Increased social support (coef. 0.11; 95% CIs: 0.08–0.15) and positive attitudes (coef. 0.21; 95% CIs: 0.14–0.29) were significantly associated with more desirable parental warmth/affection. Similarly, positive attitudes (coef. 0.16; 95% CIs 0.11–0.20), reduced distress (coef. 0.11; 95% CIs: 0.08–0.14) and increased functioning (coef. 0.03; 95% CIs: 0.01–0.04) were significantly associated with more desirable scores of parental undifferentiated rejection. While further research is needed to examine underlining mechanisms and causal pathways, our findings both link individual wellbeing characteristics with parenting behaviours and suggest further exploration into whether and how broader elements of the ecosystem may influence parenting outcomes.