bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of early motor interventions for infants with congenital heart disease and open-heart surgery
Authors: Kaeslin Rahel , Latal Beatrice , Mitteregger Elena 
Published: August 2023

Abstract
Background
Motor development delay is the first neurodevelopmental impairment that becomes apparent in infants with congenital heart disease (CHD). Early interventions have addressed high-risk groups like infants born preterm, but little is known about interventions to improve motor outcome in CHD infants at risk of motor delay. The purpose of this review was to systematically review the literature on type and effect of motor intervention applied during the first year of life in infants with CHD following open-heart surgery.

Methods
Scoping searches were performed in May 2020 and April 2023 via MEDLINE, Embase, CINAHL, Cochrane, PsycINFO, PEDro, and Scopus. The review included studies published in English from 2015 to 2022. Primary outcome was infants’ motor development measured by standardized and non-standardized motor assessments, and if available, infants’ language and cognitive development, and any parental quality-of-life assessments as secondary outcomes. The studies’ quality was evaluated with a modified Newcastle-Ottawa scale.

Results
Four papers with low to high methodological quality met inclusion criteria. All studies investigated the influence of early physiotherapy. Four studies involved parents, and three studies used standardized tools to assess motor outcomes. No conclusion can be drawn about any positive effect of early motor interventions.

Conclusions
Early motor intervention in CHD infants may improve motor development; however, the few existing studies do not provide clear evidence. Thus, more prospective early intervention studies are needed.

Trial registration
PROSPERO CRD42020200981.
Optimization of HIV testing services in Germany using HIV indicator diseases: study protocol of the HeLP study
Authors: Valbert Frederik , Koppe Uwe , Schmidt Daniel , Krings Amrei , Gunsenheimer-Bartmeyer Barbara , Dröge Patrik , Ruhnke Thomas , Behrens Georg , Bickel Markus , Boesecke Christoph , Esser Stefan , Wasem Jürgen , Neumann Anja 
Published: August 2023

Abstract
Background
Despite the potentially accompanying negative clinical, epidemiologic, and health economic effects, a large proportion of persons living with the human immunodeficiency virus (HIV) are diagnosed late. Internationally, numerous diseases are known to be HIV indicator diseases. Adequate HIV testing in the presence of HIV indicator diseases could help to diagnose unknown HIV infections earlier. The objective of the HeLP study is to validate published HIV indicator diseases for the German setting and to identify guidelines in terms of these indicator diseases in order to reduce knowledge gaps and increase HIV testing when HIV indicator diseases are diagnosed.

Methods
A mixed methods approach is used. In a first step, published HIV indicator diseases will be identified in a systematic literature review and subsequently discussed with clinical experts regarding their relevance for the German setting. For the validation of selected indicator diseases different data sets (two cohort studies, namely HIV-1 seroconverter study & ClinSurv-HIV, and statutory health insurance routine data) will be analyzed. Sensitivity analyses using different time periods will be performed. Guidelines of HIV indicator diseases validated in the HeLP study will be reviewed for mentioning HIV and for HIV testing recommendations. In addition, semi-standardized interviews (followed by a free discussion) with guideline creators will identify reasons why HIV testing recommendations were (not) included. Subsequently, a random sample of physicians in medical practices will be surveyed to identify how familiar physicians are with HIV testing recommendations in guidelines and, if so, which barriers are seen to perform the recommended tests in everyday care.

Discussion
The HeLP-study adopts the challenge to validate published HIV indicator diseases for the German setting and has the potential to close a knowledge gap regarding this objective. This has the potential to improve targeted HIV testing for patients with HIV indicator diseases and consequently lead to earlier HIV diagnosis.

Trial registration
DRKS00028743
Associations between exposure to cadmium, lead, mercury and mixtures and women’s infertility and long-term amenorrhea
Authors: McClam Maria , Liu Jihong , Fan Yihan , Zhan Tingjie , Zhang Qiang , Porter Dwayne E. , Scott Geoffrey I. , Xiao Shuo 
Published: August 2023

Abstract
Background
Cadmium (Cd), lead (Pb), and mercury (Hg) have been shown to exhibit endocrine disrupting properties. Their effects on women’s reproductive health, however, remain elusive. Here, we investigated associations between blood concentrations of Pb, Cd, Hg, and their mixture and infertility and long-term amenorrhea in women aged 20–49 years using the US National Health and Nutrition Examination Survey (NHANES) 2013–2018 cross-sectional survey.

Methods
A total of 1,990 women were included for the analysis of infertility and 1,919 women for long-term amenorrhea. The methods of log-transformation and use of quartiles were used to analyze blood heavy metal concentrations. Statistical differences in the covariates between the outcome groups were evaluated using a chi-squared test for categorical variables and a t-test for continuous variables. Multiple logistic regression models were used to examine the associations.

Results
The blood concentrations of Pb and heavy metal mixtures were significantly higher in ever-infertile women than pregnant women, but the concentrations of Cd and Hg were comparable. After full adjustment, multiple logistic regression analyses revealed a significant and dose-dependent positive association between blood Pb concentrations and women’s historical infertility, a negative association between Cd and women’s long-term amenorrhea, and no associations between Hg and heavy metal mixture and women’s infertility or long-term amenorrhea.

Conclusions
Our study suggests that exposure to heavy metals exhibit differential associations with history of infertility and amenorrhea, and Pb may adversely impact women’s reproduction and heighten the risks of infertility and long-term amenorrhea.
Influence of night-time light pollution on the photosynthesis and physiological characteristics of the urban plants Euonymus japonicus and Rosa hybrida
Authors: Wei Yaxi , Li Zhen , Zhang Jiaolong , Hu Dan 
Published: August 2023

Abstract
Background
Night-time light pollution (NLP), which breaks the natural cycle of day and night, has become a new threat to urban ecosystems. Plants are the main component of urban ecosystems and play an irreplaceable role in maintaining urban ecological balance. The effects of NLP with various radiation sources, including green, white, blue and red light provided by light-emitting diodes, on urban plants, Euonymus japonicus and Rosa hybrida, were examined in a block field experiment.

Results
NLP caused photoinhibition and oxidative stress in plants, and the extent of the deleterious effects varied with the spectral distribution of artificial light sources and species. Both E. japonicus and R. hybrida were more sensitive to blue and red light, which reduced the pigment concentration, net photosynthetic rate, stomatal limit value, effective quantum yield, apparent electron transfer rate and photochemical quenching coefficient, and markedly increased the malondialdehyde content and total antioxidant capacity. However, those negative effects under white light were only present in E. japonicus and not in R. hybrida. Furthermore, blue and red light significantly decreased the stomatal conductance of E. japonicus. In contrast, green light had no significant effect on the above indices for both species. All spectra did not significantly change the sugars and starch contents for either species.

Conclusions
Considering that the spectral distribution of artificial light at night in cities has great heterogeneity and that its effect varies with plant species, it is important to arrange tree species with NLP tolerance and install appropriate light sources in urban areas based on the corresponding physiological responses and adaptation of urban trees.
Are greenhouse gas fluxes lower from ley or perennial fallow than from arable organic soils? A systematic review protocol
Authors: Holzknecht Alena , Berglund Örjan , Land Magnus , Dessureault-Rompré Jacynthe , Elsgaard Lars , Lång Kristiina 
Published: August 2023

Abstract
Background
Cultivated peatlands are widespread in temperate and boreal climate zones. For example, in Europe about 15% of the pristine peatland area have been lost through drainage for agricultural use. When drained, these organic soils are a significant source of greenhouse gas (GHG) emissions. To reach climate goals, the agricultural sector must reduce its GHG emissions, and one measure that has been discussed is changing land use from cropland to ley production or perennial green fallow. This management change leads to lower reported emissions, at least when using the IPCC default emission factors (EF) for croplands and grasslands on organic soils (IPCC 2014). However, there was a limited background dataset available for developing the EFs, and other variables than management affect the comparison of the land use options when the data originates from varying sites and years. Thus, the implications for future policies remain uncertain. This protocol describes the methodology to conduct a systematic review to answer the question of whether ley production or perennial green fallow can be suggested as a valid alternative to annual cropping to decrease GHG emissions on organic soils in temperate and boreal climate.

Methods
Publications will be searched in different databases and bibliographies of relevant review articles. The comprehensiveness of the search will be tested through a list of benchmark articles identified by the protocol development team. The screening will be performed at title and abstract level and at full text level, including repeatability tests. Eligible populations are organic agricultural soils in temperate and boreal climate regions. Interventions are grasslands without tillage for at least 3 years, and comparators are annual cropping systems within the same study as the intervention. The outcome must be gas fluxes of either carbon dioxide (CO2), nitrous oxide (N2O), or methane (CH4), or any combination of these gases. Studies will go through critical appraisal, checking for internal and external validity, and finally data extraction. If possible, a meta-analysis about the climate impact of perennial green fallow compared to annual cropping on organic soils will be performed.
Moral disengagement, self-control and callous-unemotional traits as predictors of cyberbullying: a moderated mediation model
Authors: Li Haojian , Guo Qi , Hu Ping 
Published: August 2023

Abstract
Background
Cyberbullying has become more prevalent, more difficult to detect, and more harmful to the victims. Whereas considerable prior work has investigated predictors and consequences of cyberbullying, additional research is needed to better understand the mechanisms by which these factors relate to cyberbullying perpetration and victimization. The goal of the present study was to examine the extent to which the link between individual differences in moral disengagement and cyberbullying perpetration is mediated by low self-control and, if so, whether this mediation effect varies by individuals’ degree of callous-unemotional traits.

Method
To explore these questions, we used cyberbullying, moral disengagement, self-control, and callous-unemotional traits scales and collected online survey data from a sample of 860 Chinese internet users aged 18 years old or older.

Result
As hypothesized, a significant positive relation between moral disengagement and cyberbullying emerged that was mediated by individual differences in self-control. Additionally, evidence of moderated mediation was found. That is, the indirect effect varied by degree of callous-unemotional traits, with a significantly stronger mediation effect (and association between self-control and cyberbullying) for individuals who were relatively higher in callous-unemotional traits.

Conclusion
We conclude that moral disengagement partially predicts cyberbullying through self-control, while callous-unemotional traits moderate the pathway between self-control and cyberbullying.
The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance
Authors: Sicking Mark , Falke Isabel , Löblein Maria T. , Eich Hans Th. , Götte Martin , Greve Burkhard , Troschel Fabian M. 
Published: August 2023

AbstractRNA-binding proteins have increasingly been identified as important regulators of gene expression given their ability to bind distinct RNA sequences and regulate their fate. Mounting evidence suggests that RNA-binding proteins are involved in the onset and progression of multiple malignancies, prompting increasing interest in their potential for therapeutic intervention.The Musashi RNA binding proteins Musashi-1 and Musashi-2 were initially identified as developmental factors of the nervous system but have more recently been found to be ubiquitously expressed in physiological tissues and may be involved in pathological cell behavior. Both proteins are increasingly investigated in cancers given dysregulation in multiple tumor entities, including in female malignancies. Recent data suggest that the Musashi proteins serve as cancer stem cell markers as they contribute to cancer cell proliferation and therapy resistance, prompting efforts to identify mechanisms to target them. However, as the picture remains incomplete, continuous efforts to elucidate their role in different signaling pathways remain ongoing.In this review, we focus on the roles of Musashi proteins in tumors of the female – breast, endometrial, ovarian and cervical cancer – as we aim to summarize current knowledge and discuss future perspectives.
Sensitivity of slip distribution on tsunami trace heights and geological evidences: a case study of the 2011 Tohoku-Oki earthquake
Authors: Kusumoto Satoshi , Imai Kentaro , Hori Takane , Sugawara Daisuke , Satake Kenji 
Published: August 2023

AbstractWe examined whether it is possible to estimate the tsunami source model of the 2011 Tohoku-Oki earthquake from a comparison of numerical simulations of tsunami propagation and sediment transport, the measured trace heights, and the sediment thickness of tsunami deposits. Twelve models with different subfault numbers were prepared based on a reference model inferred from tsunami waveform inversion. The reference model with 55 subfaults considering rupture propagation and the model with instantaneous slip successfully reproduced both the tsunami trace heights and sediment thickness distribution of tsunami deposits in the Idagawa Lowland and Sendai Plain. Other models with the same moment magnitude but fewer subfaults could not reproduce the observed trace heights, and the reproducibility of sediment thickness distribution strongly depended on the slip distribution. Models with increased slip amounts and moment magnitude could reproduce the trace heights; however, the simulated sediment thickness was underestimated for the Idagawa Lowland while overestimated for the Sendai Plain. Our results indicate that the combination of trace heights, sediment thickness of tsunami deposits, and numerical simulations of tsunami propagation and sediment transport can be used to estimate historical earthquakes and tsunamis. Efforts should be made to increase the number of subfaults for the study of historical events, although the obtained solutions may not be unique because of fewer trace heights or tsunami deposit data.
Implementation resources to support teachers’ use of behavioral classroom interventions: protocol of a randomized pilot trial
Authors: Lawson Gwendolyn M. , Owens Julie Sarno , Mandell David S. , Tavlin Samantha , Rufe Steven , Lyon Aaron R. , Eiraldi Ricardo , Power Thomas J. 
Published: August 2023

Abstract
Background
Teacher-delivered behavioral classroom management interventions are effective for students with or at-risk for attention-deficit/hyperactivity disorder (ADHD) or other disruptive behavior challenges, but they can be difficult for teachers to use in the classroom. In this study, we will pilot test a package of implementation strategies to support teachers in using behavioral classroom interventions for students with ADHD symptoms.

Methods
We will use a 2-group, randomized controlled trial to compare outcomes for teachers who receive Positive Behavior Management Implementation Resources (PBMIR), a theory and data-driven implementation resource package designed to increase teacher implementation of behavioral classroom management interventions, with those who do not receive this additional implementation support. We will measure teacher implementation outcomes (e.g., observed fidelity to behavioral classroom interventions) and student clinical outcomes (e.g., ADHD-related impairment, ADHD symptoms, student–teacher relationship, academic performance) before and after an 8-week intervention period for both groups; we will also measure teacher-reported acceptability, appropriateness, and feasibility for the PBMIR group following the intervention period.

Discussion
If there is preliminary evidence of feasibility and effectiveness, this pilot study will provide the foundation for evaluation the PBMIR at a larger scale and the potential to improve outcomes for students with or at risk for ADHD.

Trial registration
This clinical trial was registered at ClinicalTrials.gov. (https://clinicaltrials.gov/) on 8/5/2022 which was prior to the time of first participant enrollment. The registration number is: NCT05489081.
The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains
Authors: Luo Quan-Feng 
Published: August 2023

Abstract
Background
Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains.

Results
Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases.

Conclusion
Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment.
Sex-specific prevalence, awareness, treatment and control of hypertension in adults in India: a study for developing sex-specific public policy from the longitudinal ageing study in India (LASI) data 2017–2018
Authors: Singh Ayushi , Dixit Priyanka 
Published: August 2023

Abstract
Background and objective
Hypertension is a key risk factor for cardiovascular disease and the leading cause of mortality among Indian adults. The difference in health status between men and women is becoming a great burden in itself worldwide. This study aimed to examine the differences between men and women in the prevalence, awareness, treatment, and control of hypertension and related risk factors among people aged 45 and older in India using data from the Longitudinal Ageing Study in India in 2017–2018.

Methods
Descriptive statistics were presented separately for males and females. Multivariable logistic regression was used to analyze the socio-demographic, lifestyle behaviours, and biological factors associated with the prevalence of hypertension. All statistical analyses were conducted using Stata Version 16.0 statistical software. The study of the data was conducted using survey weights available in the LASI datasets.

Key findings
Overall, the study found that 45.1% of the study population had hypertension, with 26.9% self-reporting their condition and 30% having hypertension at the time of measurement. Approximately 41% of males and 59% of females had hypertension. The self-reported hypertension of men was found to differ significantly from measured hypertension by 8.7%, while in women the difference was only 1.2%. Diabetes was found to increase the odds of having hypertension in both males (OR = 3.65, 95% CI (3.37–3.97)) and females (OR = 3.46, 95% CI (3.21–3.74)).

Conclusion
The difference between self-reported and measured hypertension in men and women is contributing to sex-gender and health inequalities that must be addressed. For adult females with hypertension, it is important to prioritize obesity, education level, physical activity, and regular clinic visits to manage chronic conditions. Based on our findings, policy recommendations can be made to focus on increasing women's literacy, promoting men's screening for hypertension, banning tobacco and alcohol sales, and organizing hypertension awareness campaigns specifically for men and in rural areas.