bluuebunny/crossref_metadata_2025_split huggingface dataset:
Play and Freedom: Patterns of Life in the Spirit
Authors: Zahl Simeon 
Published: June 2023

AbstractThis article explores the pneumatological theme of the freedom of the Spirit from the perspective of experience. It deploys a recently developed methodology of attending to affective and experiential dynamics in pneumatology to identify two significant patterns or modalities of Christian life in the Spirit that are indexed to the Spirit's freedom: a pattern of divine resistance to human attempts to control God, characterized on the human side by experiences of disruption as well as dynamic creativity; and a pattern of life free from the tyranny of the law, characterized by a modality of play or playfulness, as explored in the work of Nimi Wariboko. In identifying and illuminating these patterns, this article extends a project of seeking to make explicit the connections between Christian doctrinal concepts and Christian experience into a new domain, and responds to a long‐standing concern that theologies of sanctification emphasizing freedom have little to say about the positive shape of Christian life in the Spirit.
Learning from the past and present to change the future: Endoscopic management of upper urinary tract urothelial carcinoma
Authors: Yoshida Takashi , Ohe Chisato , Nakamoto Takahiro , Kinoshita Hidefumi 
Published: June 2023

AbstractCurrent guidelines recommend endoscopic management (EM) for patients with low‐risk upper urinary tract urothelial carcinoma, as well as those with an imperative indication. However, regardless of the tumor risk, radical nephroureterectomy is still mainly performed worldwide despite the benefits of EM, such as renal function maintenance, no hemodialysis requirement, and treatment cost reduction. This might be explained by the association of EM with a high risk of local recurrence and progression. Furthermore, the need for rigorous patient selection and close surveillance following EM may be relevant. Nevertheless, recent developments in diagnostic modalities, pathological evaluation, surgical devices and techniques, and intracavitary regimens have been reported, which may contribute to improved risk stratification and treatments with superior oncological outcomes. In this review, considering recent advances in endourology and oncology, we propose novel treatment strategies for optimal EM.
Nanoscale toughening of low carbon Al2O3‐C refractories by means of SiCnw/Al2O3 composite reinforcement
Authors: Chong Xiaochuan , Luo Jiyuan , Ding Donghai , Jin Shengli , Xiao Guoqing 
Published: June 2023

AbstractTo improve the thermal shock resistance of low carbon Al2O3‐C refractories, SiC nanowires (SiCnw) containing SiCnw/Al2O3 composite reinforcement were introduced. The specific fracture energy of the Al2O3‐C refractory matrix was obtained by statistical grid nano‐indentation. The reinforcement mechanism of SiCnw/Al2O3 on thermal shock resistance of refractories was investigated. The results revealed that the matrix‐specific fracture energy of A6 (6 wt% SiCnw/Al2O3 added) was 217 N/m, which was 58.4% higher than reference sample A0 (137 N/m) and 18.6% higher than MA6 (183 N/m, 6 wt% SiC/Al2O3 added). A6 showed the highest residual strength ratio of 49.8%, which was 114.7 % higher than A0 (23.2%) and 82.4 % higher than MA6 (27.3%). The components with different morphology in SiCnw/Al2O3 cluster, especially SiC nanowires, promote the generation of microcracks, crack multi‐deflection, and branching, which toughen the matrix and improve the thermal shock resistance of refractories. In comparison to the literature, A6 showed a higher rising in residual strength ratio than those with higher graphite content (4 wt% and 20 wt%), which will greatly reduce the consumption of carbon‐containing refractories and contribute to the reduction of CO2 emission.
Healthcare workers' experiences of patient safety in the intensive care unit during the COVID‐19 pandemic: A multicentre qualitative study
Authors: Berggren Karin , Ekstedt Mirjam , Joelsson‐Alm Eva , Swedberg Lena , Sackey Peter , Schandl Anna 
Published: June 2023

AbstractAimTo describe healthcare workers' experiences of preconditions and patient safety risks in intensive care units during the COVID‐19 pandemic.BackgroundHealthcare workers' ability to adapt to changing conditions is crucial to promote patient safety. During the COVID‐19 pandemic, healthcare workers' capacity to maintain safe care was challenged and a more in‐depth understanding on frontline experiences of patient safety is needed.DesignA qualitative descriptive design.MethodsIndividual interviews were conducted with 29 healthcare workers (nurses, physicians, nurse assistants and physiotherapists) from three Swedish hospitals directly involved in intensive care of COVID‐19 patients. Data were analysed with inductive content analysis. Reporting followed the COREQ checklist.ResultsThree categories were identified. Hazardous changes in working conditions describes patient safety challenges associated with the extreme workload with high stress level. Imperative adaptations induced by changed preconditions for patient safety which include descriptions of safety risks following adaptations related to temporary intensive care facilities, handling shortage of medical equipment and deviations from routines. Safety risks triggered by reorganisation of care describe how the diluted skill‐mix and team disruptions exposed patients to safety risks, and that safety performance mostly relied on individual healthcare worker's responsibility.ConclusionsThe study suggests that healthcare workers experienced an increase in patient safety risks during the COVID‐19 pandemic mainly because the extremely high workload, imperative adaptations, and reorganisation of care regarding skill‐mix and teamwork. Patient safety performance relied on the individuals' adaptability and responsibility rather than on system‐based safety.Relevance to Clinical PracticeThis study provides insights on how healthcare workers' experiences can be used as a source of information for recognition of patient safety risks. To improve detection of safety risks during future crises, guidelines on how to approach safety from a system perspective must include healthcare workers' perceptions on safety risks.Patient and Public ContributionNone in the conceptualisation or design of the study.
“Because I feel like I want to be heard, you know?:” Carceral citizenship and collateral consequences
Authors: Ewald Alec C. 
Published: June 2023

AbstractJoining a critical literature on carceral citizenship in the United States, this article represents one of the first academic efforts to ascertain the ideas of people with criminal records about “collateral consequences,” which are the civil restrictions often facing people with records. In 32 extended interviews with people visiting a reentry organization in New York City, a majority argued that people with conviction backgrounds should be eligible to vote and serve on juries, and most said they would like to be able to participate themselves. Interviewees did express intensely skeptical ideas, particularly about the police and employers, but this was a limited or bounded cynicism. Distrust and antagonism toward specific institutions existed alongside a strongly‐stated desire to engage in civic activity.
Microplastics in the menu of Mediterranean zooplankton: Insights from the feeding response of the calanoid copepod Centropages typicus
Authors: Traboni Claudia , Sarno Diana , Ribera d'Alcalà Maurizio , Mazzocchi Maria Grazia 
Published: June 2023

AbstractMicroplastic input into the ocean represents an increasing threat to marine biota and may endanger the functioning of marine ecosystems, especially in semi‐enclosed basins, such as the Mediterranean Sea. The size spectrum of microplastics overlaps with that of nano‐microplankton (2–200 μm), thus potentially misleading suspension‐feeding zooplankton, which represent a key trophic link in pelagic food webs. We investigated the effects of microplastics on the feeding performance of the copepod Centropages typicus in laboratory experiments. Adult females were incubated in natural prey assemblages under different conditions: without and with nutrient enrichment, and in the presence and absence of microplastics (20–1000 μm). Non‐significant changes were recorded in either copepod ingestion rates or daily rations upon microplastic addition. However, the copepod diet shifted significantly in the presence of microplastics, as the copepods fulfilled their individual carbon requirements by ingesting different protistan prey. The number of microplastic particles found in copepod guts (0.9 particles ind.−1) and fecal pellets (2.1 particles pellet−1) was low and particles occurred mostly in the lower size range (∽20 μm). Overall, the exposure of C. typicus to microplastics did not affect the copepod daily intake of food, likely due to the avoidance of microplastics and flexible feeding habits.
Maternal effect senescence via reduced DNA repair ability in the three‐spined stickleback
Authors: Kim Sin‐Yeon , Chiara Violette , Álvarez‐Quintero Náyade , da Silva Alberto , Velando Alberto 
Published: June 2023

AbstractMaternal effect senescence, a decline in offspring viability with maternal age, has been documented across diverse animals, but its mechanisms remain largely unknown. Here, we test maternal effect senescence and explore its possible molecular mechanisms in a fish. We compared the levels of maternal mRNA transcripts of DNA repair genes and mtDNA copies in eggs and the levels of DNA damage in somatic and germline tissues between young and old female sticklebacks. We also tested, in an in vitro fertilization experiment, whether maternal age and sperm DNA damage level interactively influence the expression of DNA repair genes in early embryos. Old females transferred less mRNA transcripts of DNA repair genes into their eggs than did young females, but maternal age did not influence egg mtDNA density. Despite a higher level of oxidative DNA damage in the skeletal muscle, old females had a similar level of damage in the gonad to young females, suggesting the prioritization for germline maintenance during ageing. The embryos of both old and young mothers increased the expression of DNA repair genes in response to an increased level of oxidative DNA damage in sperm used for their fertilization. The offspring of old mothers showed higher rates of hatching, morphological deformity and post‐hatching mortality and had smaller body size at maturity. These results suggest that maternal effect senescence may be mediated by reduced capacity of eggs to detect and repair DNA damages, especially prior to the embryonic genomic activation.
Unique dentition of rhynchosaurs and their two‐phase success as herbivores in the Triassic
Authors: Sethapanichsakul Thitiwoot , Coram Robert A. , Benton Michael J. 
Published: June 2023

AbstractRhynchosaurs were key herbivores over much of the world in the Middle and Late Triassic, often dominating their faunas ecologically, and much of their success may relate to their dentition. They show the unique ankylothecodont mode of tooth implantation, with deep roots embedded in the bone of the jaw and low crowns that were rapidly worn down in use. During growth, the main area of oral food processing, located in the middle and posterior portions of the occlusal surfaces of the jaws, moved posteriorly relative to the anterior tips of the jaws, which curved up. As the maxilla and dentary grew by addition of new bone posteriorly, the dental lamina fed in new teeth at the back of the tooth rows. CT scanning of the holotype skull of Bentonyx sidensis from the Middle Triassic of England reveals previously concealed details of the dentition. Together with new dentary material from the same location, this has enabled us to examine the tooth replacement process and elucidate ontogenetic changes in dentition and jaw morphology as the animals aged. There were major changes in rhynchosaur anatomy and function through their evolutionary history, with the early forms of the Middle Triassic dying out before or during the Carnian Pluvial Episode (233–232 Ma), and the subclade Hyperodapedontinae, with broad skulls and adaptations to chop tough vegetation, subsequently diversifying worldwide in a successful ecological expansion until their global extinction 227–225 Ma.
Genetic variation in ZmWAX2 confers maize resistance to Fusarium verticillioides
Authors: Ma Peipei , Liu Enpeng , Zhang Zhirui , Li Tao , Zhou Zijian , Yao Wen , Chen Jiafa , Wu Jianyu , Xu Yufang , Zhang Huiyong 
Published: June 2023

SummaryFusarium verticillioides (F. verticillioides) is a widely distributed phytopathogen that incites multiple destructive diseases in maize, posing a grave threat to corn yields and quality worldwide. However, there are few reports of resistance genes to F. verticillioides. Here, we reveal that a combination of two single nucleotide polymorphisms (SNPs) corresponding to ZmWAX2 gene associates with quantitative resistance variations to F. verticillioides in maize through a genome‐wide association study. A lack of ZmWAX2 compromises maize resistance to F. verticillioides‐caused seed rot, seedling blight and stalk rot by reducing cuticular wax deposition, while the transgenic plants overexpressing ZmWAX2 show significantly increased immunity to F. verticillioides. A natural occurrence of two 7‐bp deletions within the promoter increases ZmWAX2 transcription, thus enhancing maize resistance to F. verticillioides. Upon Fusarium stalk rot, ZmWAX2 greatly promotes the yield and grain quality of maize. Our studies demonstrate that ZmWAX2 confers multiple disease resistances caused by F. verticillioides and can serve as an important gene target for the development of F. verticillioides‐resistant maize varieties.
Clinal variation in PHY (PAS domain) and CRY (CCT domain)—Signs of local adaptation to light quality in Norway spruce
Authors: Ranade Sonali Sachin , García‐Gil María Rosario 
Published: June 2023

AbstractDetection of the genomic basis of local adaptation to environmental conditions is challenging in forest trees. Phytochromes (PHY) and cryptochromes (CRY) perceive the red (R)/far‐red (FR) and blue light respectively, thus playing a fundamental role in regulating plant growth and development. PHYO and PHYP from conifers are the equivalents of PHYA/PHYC and PHYB in angiosperms, respectively. Norway spruce shows an adaptive latitudinal cline for shade (low R:FR or FR‐enriched light) tolerance and requirement of FR light for its growth. We analyzed the exome capture data that included a uniquely large data set of 1654 Norway spruce trees sampled across many latitudes in Sweden to capture the natural clines for photoperiod and FR light exposure during the growth season. Statistically significant clinal variation was detected in allele and genotype frequencies of missense mutations in coding regions belonging to well‐defined functional domains of PHYO (PAS‐B), PHYP2 (PAS fold‐2), CRY1 (CCT1) and CRY2 (CCT2) that strongly correlates with the latitudinal gradient in response to variable light quality in Norway spruce. The missense SNP in PHYO resulting in Asn835Ser, displayed the steepest cline among all other polymorphisms. We propose that these variations in the photoreceptors represent signs of local adaptation to light quality.
Clinical and epidemiological profile of lichen striatus in children—Experience from a tertiary care hospital
Authors: Mendiratta Vibhu , Meena Amit Kumar 
Published: June 2023

AbstractWe analyzed records of 30 patients with lichen striatus (age < 18 years) in this retrospective study. Seventy percent were females and 30% were males with a mean age of diagnosis of 5.38 ± 4.22 years. The most common age group affected was 0–4 years. The mean duration of lichen striatus was 6.66 ± 4.22 months. Atopy was present in 9 (30%) patients. Although LS is a benign self‐limited dermatosis, long‐term prospective studies with a greater number of patients will help in better understanding of the disease including its etiopathogenesis and association with atopy.
Hidden treasures or red flags? A recruiter's view of (not) hiring former entrepreneurs into corporate jobs
Authors: Feng Jie , Wang Danni , Huang Lei , Zhang Ruoyong 
Published: June 2023

AbstractEntrepreneurs may enter the labor market to seek alternative employment opportunities, and their job applications are gaining increasing attention. With a focus on the recruiting side, we leverage the role congruity theory to examine how recruiters with various characteristics and backgrounds assess former entrepreneurs who apply for corporate jobs. We propose that job applicants with entrepreneurial experience will systematically receive fewer offers than otherwise equally qualified non‐entrepreneur applicants. However, we also suggest that this “entrepreneurship‐penalty effect” will be weakened when the recruiters are female, have shorter organizational tenure, or have entrepreneurial experience. We tested our hypotheses in a policy‐capturing experiment with follow‐up surveys using a sample collected in 2019 and 2022, that is, before and after the outbreak of COVID‐19. We found general support for our hypotheses and identified recruiters’ preferences for entrepreneur‐applicants at two‐time points. Results revealed that recruiters of different characteristics and backgrounds had varying assessments of former entrepreneur applicants, which provides implications for both sides of recruitment.
Outcomes of pediatric deceased donor kidney transplant in northeast Thailand
Authors: Ratviset Preeyapat , Panombualert Sunee , Chathum Kannika , Wisanuyotin Suwannee 
Published: June 2023

AbstractBackgroundKidney transplantation (KT) is the best therapy in children with end‐stage renal disease (ESRD), however, improving long‐term graft survival remains challenging. The aim of this study was to determine graft survival and potential risk factors in pediatric patients who undergo deceased donor KT with a steroid‐based regimen.MethodsThe medical records of children who underwent their first deceased donor KT in Srinagarind Hospital (Khon Kaen, Thailand) between 2001 and 2020 were reviewed.ResultsSeventy‐two patients were studied. Male adolescents were the predominant recipients and the majority of donors were young adult males. Non‐glomerular disease, particularly hypoplastic/dysplastic kidney disease, was the major cause of ESRD (48.61%). The mean cold ischemic time (CIT) was 18.29 ± 5.29 h. Most of the recipients had more than 4 human leukocyte antigen (HLA) mismatched loci with positive HLA‐DR mismatch (52.78%). Induction therapy was administered in 76.74% of recipients. Tacrolimus plus mycophenolate sodium and prednisolone was the most common immunosuppressive maintenance regimen (69.44%). Graft failure occurred in 18 patients, mostly due to graft rejection (50%). Graft survival at 1, 3, and 5 years after KT were 94.40%, 86.25%, and 74.92%, respectively. The only significant risk factor of graft failure in this study was delayed graft function (DGF) (adjusted HR = 3.55; 95%CI: 1.14, 11.12; p = .029). Patient survival at 1, 3, and 5 years was 100%, 98.48%, and 96.19%, respectively.ConclusionThe short‐term outcomes of pediatric KT from deceased donors were satisfactory; however, prevention of DGF would result in better outcomes.
Life‐threatening variceal bleeding after liver transplantation and extensive portal vein thrombosis: Desperate times call for desperate measures
Authors: de Assis AndréMoreira , de Carvalho Melo José Andrade , Kawakami Willian Yoshinori , Moreira Airton Mota , Carnevale Francisco Cesar , Massami Hayashi , Hirschfeld Adriana Porta Miche , Pugliese Renata Pereira Sustovich , Foronda Flavia Krepel , Paulino Ricardo Gorgulho , de Araújo André Augusto , Fonseca Eduardo Antunes , Seda Neto João 
Published: June 2023

AbstractBackgroundThe management of complex, intra‐ and extrahepatic portal vein thrombosis (PVT) after liver transplantation (LT) is challenging. Although most of the patients remain asymptomatic or oligosymptomatic in the chronic setting, some of them may develop severe portal hypertension and related complications, notably gastrointestinal (GI) bleeding. In the emergency scenario, clinical and endoscopic treatments as well as intensive support constitute the bases of conservative management, while more definitive treatment options such as surgical shunting and retransplantation are related to high morbidity rates. Transjugular intrahepatic portosystemic shunt (TIPS) was largely considered of limited role due to technical difficulties arising from extensive PVT. Recently, however, new minimally invasive image‐guided techniques emerged, allowing portal vein recanalization and TIPS creation simultaneously (TIPS‐PVR), even in complex PVT pretransplant patients.MethodsHerein, we describe a novel indication for TIPS‐PVR in a post‐LT adolescent presenting with life‐threatening, refractory GI bleeding.ResultsThe patient presented with complete resolution of the hemorrhagic condition after the procedure, with no deterioration of hepatic function or hepatic encephalopathy. Follow‐up Doppler ultrasound after TIPS‐PVR showed normal hepatopetal venous flow within the stents, and no evidence of complications, including intraperitoneal or peri splenic bleeding.ConclusionsThis report describes the feasibility of TIPS‐PVR in the post‐LT scenario complicated by extensive PVT. In this case, a complete resolution of the life‐threatening GI bleeding was achieved, with no major complications. Other patients with complex chronic PVT might benefit from the use of the described technique, but further studies are required to determine the correct timing and indications of the procedure, eventually before the occurrence of life‐threatening complications.
MCP‐1/CCR2 axis is involved in the regulation of γδT cells in lupus nephritis
Authors: Deng Ting , Lei Feifei , Wang Zhongyu , Wang Yangbin , Li Gang , Zhu Yunhe , Du Boyu , Xi Xueyan 
Published: June 2023

AbstractγδT cells are important innate immune cells that are involved in the occurrence and development of autoimmune diseases such as systemic lupus erythematosus (SLE). Lupus nephritis (LN) is a serious complication of SLE, characterized by the accumulation of immune cells (including γδT cells) in the target organs to participate in the disease process. Therefore, clarifying how γδT cells chemotactically migrate to target organs may be a key to developing therapeutic methods against LN. Enzyme‐linked immunosorbent assay (ELISA) was used to detect serum levels of chemokines in LN patients and healthy controls. Real‐time polymerase chain reaction (RT‐PCR) and flow cytometry were used to measure the expression of chemokine receptors on the surface of γδT cells. The chemotactic migration ability of γδT cells was detected by Transwell assay. Signalling pathway activation of γδT cells was detected by Automated Capillary Electrophoresis Immunoassay and flow cytometry. The serum levels of chemokines, including monocyte chemoattractant protein‐1 (MCP‐1) in LN patients, were significantly increased. CCR2, the receptor of MCP‐1, was also highly expressed on the surface of peripheral γδT cells in LN patients. In addition, the exogenous addition of MCP‐1 can enhance chemotactic migration of γδT cells in LN patients. MCP‐1 could activate STAT3 signalling in LN patients' peripheral γδT cells. γδT cells might participate in the pathogenesis of LN through MCP‐1/CCR2 axis. This finding provides new opportunities for developing treatment methods against LN by targeting MCP‐1/CCR2 axis.