bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wheelchair rugby players maintain sprint performance but alter propulsion biomechanics after simulated match play
Authors: Briley Simon J. , O’Brien Thomas J. , Oh Yim‐Taek , Vegter Riemer J. K. , Chan Mui , Mason Barry S. , Goosey‐Tolfrey Victoria L. 
Published: June 2023

AbstractThe study aimed to explore the influence of a sports‐specific intermittent sprint protocol (ISP) on wheelchair sprint performance and the kinetics and kinematics of sprinting in elite wheelchair rugby (WR) players with and without spinal cord injury (SCI). Fifteen international WR players (age 30.3 ± 5.5 years) performed two 10‐s sprints on a dual roller wheelchair ergometer before and immediately after an ISP consisting of four 16‐min quarters. Physiological measurements (heart rate, blood lactate concentration, and rating of perceived exertion) were collected. Three‐dimensional thorax and bilateral glenohumeral kinematics were quantified. Following the ISP, all physiological parameters significantly increased (p ≤ 0.027), but neither sprinting peak velocity nor distance traveled changed. Players propelled with significantly reduced thorax flexion and peak glenohumeral abduction during both the acceleration (both −5°) and maximal velocity phases (−6° and 8°, respectively) of sprinting post‐ISP. Moreover, players exhibited significantly larger mean contact angles (+24°), contact angle asymmetries (+4%), and glenohumeral flexion asymmetries (+10%) during the acceleration phase of sprinting post‐ISP. Players displayed greater glenohumeral abduction range of motion (+17°) and asymmetries (+20%) during the maximal velocity phase of sprinting post‐ISP. Players with SCI (SCI, n = 7) significantly increased asymmetries in peak power (+6%) and glenohumeral abduction (+15%) during the acceleration phase post‐ISP. Our data indicates that despite inducing physiological fatigue resulting from WR match play, players can maintain sprint performance by modifying how they propel their wheelchair. Increased asymmetry post‐ISP was notable, which may be specific to impairment type and warrants further investigation.
Expanding Frontiers of Commercial Gentrification: Rent Gap and Sequential Gentrification in Taikoo Li of Chengdu, China
Authors: Huang Xing , Gu Hao 
Published: June 2023

AbstractGentrification has become one of the planetary processes in reorganising urban spaces. China is not immune to the process. Generations of scholarship on gentrification in China have generated considerable insights into its varying logics, morphologies and mechanism in the Chinese context. Yet, most research tends to focus on a geographically well‐demarcated area, driven either by the state or capital, while overlooking the externalities of these projects over time. Through the notion of the rent gap and the empirical case of Taikoo Li in Chengdu, we develop the new dynamic formation of the rent gap theoretical framework to explain how a commercial gentrification project changed the urban centre space and trigger new rounds of the effects of gentrification in surrounding neighbourhoods. In so doing, we underscore the hitherto overlooked roles of time and scale in theorising rent gap and gentrification in China.
The Impossible Portrait
Authors: DATTATREYAN ETHIRAJ GABRIEL 
Published: June 2023

ABSTRACTThis article focuses on a portrait of a young Somali man living in Delhi, India. The portrait depicts him in a park in South Delhi wearing a cap distributed by the Aam Aadmi Party (AAP) during their insurgent 2012‐2013 campaign to establish themselves as an alternative political force. I argue this parodic portrait and the text it accrues in its circulations on Facebook functions as anetworked image‐eventthat evinces the impossible contradictions that Somalis face in India. Tracing this networked image event reveals how a surging antiblackness linked to the rise of the AAP Party in Delhi punctuates the in‐betweenness that Somalis experience while they wait for life elsewhere.
Cyclical 10‐day dosing of melphalan for canine multiple myeloma
Authors: Teddy Lucy , Sylvester Skylar R. , O'Connor Kelly S. , Hume Kelly R. 
Published: June 2023

AbstractCanine multiple myeloma (MM) is typically treated with melphalan chemotherapy. A protocol with repeated 10‐day cyclical dosing of melphalan has been used at our institution but has not been described in the literature. Our objectives were to describe the outcome and adverse events of this protocol in a retrospective case series. We hypothesised the cyclical 10‐day protocol would have similar outcomes compared to other reported chemotherapy protocols. Dogs diagnosed with MM that received melphalan treatment at Cornell University Hospital for Animals were identified through a database search. Records were retrospectively reviewed. Seventeen dogs met inclusion criteria. Lethargy was the most common presenting complaint. The median duration of clinical signs was 53 days (range, 2–150 days). Seventeen dogs had hyperglobulinemia with 16/17 having monoclonal gammopathies. Sixteen dogs had bone marrow aspiration and cytology performed at initial diagnosis and plasmacytosis was diagnosed in all. Based on serum globulin concentrations, 10 of 17 dogs (59%) achieved complete response (CR), and 3 dogs (18%) achieved partial response (PR), for an overall response rate of 76%. The median overall survival time was 512 days (range, 39–1065). Retinal detachment (n = 3) and maximum response of CR/PR (n = 13) were associated with overall survival on multivariate analysis (p = .045 and .046, respectively). Adverse events were minimal with diarrhoea being the most reported (n = 6). This cyclical 10‐day protocol was better‐tolerated with fewer adverse events than with other reported chemotherapy protocols, but response rate was also lower, likely due to a lower dosing intensity.
Perbualan berimplisit dalam Filem-Filem Klasik Malaysia (P. Ramlee): Analisis Semantik Inkuisitif
Authors: Hedel Nur Ezatull Fadtehah , Subet Mary Fatimah 
Published: June 2023

Filem-filem klasik P. Ramlee turut menggunakan perbualan tersirat dalam menyampaikan sesuatu mesej namun tidak dapat diterjemah secara harfiah. Bagi merungkai perkara tersebut, maka, dua objektif diketengahkan iaitu mengenal pasti ujaran berimplisit dalam karya filem P. Ramlee dan menganalisis pemikiran dan keintelektualan masyarakat Melayu dalam filem tersebut. kajian kualitatif dengan menggunakan reka bentuk deskriptif dan analisis kandungan. Kajian kali ini hanya mengetengahkan lima buah data filem P. Ramlee yang mendapat jumlah tontonan yang tinggi di aplikasi YouTube daripada 10 filem yang terpilih. Namun, kajian ini hanya membincangkan filem Seniman Bujang Lapok yang melimitkan dua data untuk dianalisis. Data dianalisis menggunakan pendekatan semantik inkuisitif (SI) oleh Jalaluddin (2014), dibantu dengan aplikasi teori relevans (TR) daripada Sperber dan Wilson (1986, 1995) dan Rangka Rujuk Silang (RRS) daripada Kempson (1986). Hasil kajian mendapati bahawa filem-filem P. Ramlee mengandungi unsur pemikiran dan keintelektualan masyarakat Melayu yang terserlah daripada ujaran berimplisit tersebut. Oleh itu, berpandukan pendekatan SI, TR dan RRS, pengkaji dapat mengetahui asbab penggunaan ujaran berimplisit diujarkan dalam filem P. Ramlee dengan hubung kait data, teori, kognitif dan falsafah demi mencungkil akal budi penuturnya.

Ramlee’s classic films use implicit conversation to convey a message that cannot be translated literally. To unravel this, two objectives are highlighted, which is to identify implicit conversation and to analyze the thoughts and intellect of Malay society in that films. This qualitative study uses a descriptive design and content analysis. The study focuses on five P. Ramlee films with the high views on YouTube out of ten selected films. However, this study only focuses on “Seniman Bujang Lapok” film which only limits two data for analysis. The data is analyzed using the inquisitive semantics (SI) approach by Jalaluddin (2014), assisted by the Relevance Theory (RT) by Sperber and Wilson (1986, 1995) and Bridging Cross Reference (BCR) approach by Kempson (1986). The study found that P. Ramlee’s films contain elements of Malay society’s thoughts and intellect are highlighted through implicit conversation. Therefore, by using the IS, RT and BCR, the researcher can understand the reasons using implicit conversation in P. Ramlee’s films by connecting data, theory and philosophy in order to explore the wisdom of the people in the past that are high in intellect
Fracture Resistance of Chemo-Mechanically Coupled Solid Solutions
Authors: Wang Xueju , Lu Mu , Zhou Min , Xia Shuman 
Published: June 2023

Abstract
Fracture in solid solutions, such as electrodes for lithium-ion batteries and fuel cells, is mediated by intricate interactions between solid-state diffusion and crack propagation. In this work, we developed a composition-dependent cohesive zone model and integrated it with a chemo-mechanical coupling constitutive model to study the fracture mechanisms of solid solutions. The computational framework was used to investigate the effective fracture properties of chemo-mechanically coupled solid solutions over a wide range of crack growth velocities and compositional dependence of intrinsic fracture energy. The results revealed an important characteristic crack velocity, which is set by the ratio of the diffusivity to the intrinsic fracture energy and dictates the effective fracture resistance of the material. We also applied the model to study the fracture behavior of two-phase lithiated silicon (Si) and germanium (Ge) nanostructures as candidate high-capacity anodes for next-generation lithium-ion batteries, and showed that Ge nanostructures are more fracture resistant than their Si counterparts. The computational study presented here provides important insights for the rational design, operation, and mechanical testing of chemo-mechanically active material systems for their use in energy storage and conversion.
Bounds on the Poisson’s Ratios of Diamond-Like Structures
Authors: Liu Yi , Zhang Chunbo , Yang Hang , Gao Enlai 
Published: June 2023

Abstract
Poisson’s ratios of diamond-like structures, such as cubic C, Si, and Ge, have been widely explored because of their potential applications in solid-state devices. However, the theoretical bounds on the Poisson’s ratios of diamond-like structures remain unknown. By correlating macroscopic elastic constants with microscopic force constants of diamond-like structures, we here derived analytical expressions for the minimum Poisson’s ratio, the maximum Poisson’s ratio, and the Poisson’s ratios averaged by three schemes (i.e., Voigt averaging scheme, Reuss averaging scheme, and Hill averaging scheme) as solely a function of a dimensionless quantity (λ) that characterizes the ratio of mechanical resistances to the angle bending and bond stretching. Based on these expressions, we further determined the bounds on the Poisson’s ratios, the minimum Poisson’s ratio, the maximum Poisson’s ratio, and the Poisson’s ratios averaged by three schemes (i.e., Voigt averaging scheme, Reuss averaging scheme, and Hill averaging scheme), which are (−1, 4/5), (−1, 1/5), (0, 4/5), (−1, 1/2), (−1/3, 1/2), and (−2/3, 1/2), respectively. These results were well supported by atomistic simulations. Mechanism analyses demonstrated that the diverse Poisson’s behaviors of diamond-like structures result from the interplay between two deformation modes (i.e., bond stretching and angle bending). This work provides the roadmap for finding interesting Poisson’s behaviors of diamond-like structures.
Fifteen-minute consultation: Approach to the infant with stridor and suspected laryngomalacia
Authors: Whittaker Rachel , Nieto Hannah , Stephenson Kate 
Published: June 2023

Stridor in an infant is a significant clinical sign; the primary objectives are to ensure that the airway is safe and to arrange timely, appropriate management. A structured history, examination and targeted investigations will determine the cause and guide care.Laryngomalacia is the most common cause of stridor in an infant. The stridor tends to start shortly after birth, classically presenting as a positional stridor in the first month, which gradually resolves before 12–18 months of age in mild cases. There is a wide spectrum of severity; few require surgical intervention. This article will outline how the infant is appropriately assessed and managed.
Incidence of infant Gram-negative invasive bacterial infections in England, 2011–2019: an observational study using population-wide surveillance data
Authors: Hallmaier-Wacker Luisa K , Andrews Amelia , Hope Russell , Demirjian Alicia , Lamagni Theresa L , Collin Simon M 
Published: June 2023

ObjectiveInvasive bacterial infections account for an estimated 15% of infant deaths worldwide. We aimed to estimate the incidence and trends in invasive bacterial infections in infants caused by Gram-negative pathogens in England during 2011–2019.MethodsLaboratory-confirmed invasive bacterial infections in infants (<1 year old) were identified in the UK Health Security Agency national laboratory surveillance data from April 2011 to March 2019. Polymicrobial infections were defined as two or more bacterial species from the same normally sterile sample site. Early-onset infections were defined as <7 days from birth and late-onset as ≥7 days (neonates 7–28 days; infants ≥29 days). Trend analyses were carried out using Poisson (for episodes/incidence) and beta (for proportions) regression.ResultsThe annual incidence of invasive bacterial infections increased by 35.9%, from 189.8 to 258.0 cases per 100 000 live births (p<0.001). Late-onset infections in both neonates and infants increased substantially over the study period (p<0.001), whereas early-onset infections increased slightly (p=0.002).Escherichia coliwas the most common Gram-negative pathogen isolated and accounted for 27.2% of the overall rise in Gram-negative infant disease incidence. Polymicrobial infections almost doubled, increasing from 29.2 to 57.7 per 100 000 live births (p<0.001), and mostly involved two species (81.3%, 1604/1974 episodes).ConclusionsThe incidence of Gram-negative invasive bacterial infections in infants increased between 2011/2012 and 2018/2019 in England, driven mainly by an increase in late-onset infections. Further work is required to elucidate the risk factors and drivers of this increased incidence so that opportunities for prevention can be identified.
How much does it cost to implement a community-based walking football programme for patients with type 2 diabetes?
Authors: Barbosa Ana , Brito João , Figueiredo Pedro , Seabra André , Ding Ding , Mendes Romeu 
Published: June 2023

ObjectivesThe current study analysed the implementation costs of a community-based walking football exercise programme for patients with type 2 diabetes.MethodsThe direct costs of a community-based walking football programme for middle-aged and older male patients with type 2 diabetes, designed and tested in Porto (Portugal), were calculated from the payer’s perspective. One season of this programme consists of three sessions per week (60 min per session) for nine months (October to June). Cost calculations were based on two groups of 20 patients and included the sports infrastructure and equipment, human resources, pre-exercise clinical evaluation, medical equipment, technical training and other consumable costs. An economic depreciation of 1 year using the linear method for sports and electronic materials was considered. Cost analysis dated December 2021 and is expressed in international dollars ($).ResultsThis programme was estimated to have a total implementation cost of $22 923.07; $2547.01/month; $573.08/patient; $106.13/session; $63.68/patient/month and $5.31/patient/session.ConclusionA community-based walking football programme for patients with type 2 diabetes is affordable and can be scaled up by local communities to promote physical activity and manage type 2 diabetes with the involvement of multiple stakeholders such as the football clubs, municipalities and primary healthcare units.
Why is pain management so difficult in the Emergency Department? A systematic mixed studies review and thematic synthesis of staff perceptions of enablers and barriers to pain management within the Emergency Department
Authors: Sampson Fiona C , Johnson Maxine 
Published: June 2023

IntroductionPain is the most common presenting feature within the ED, yet undertreatment of pain in the ED is a well-documented problem worldwide. Despite the development of interventions to address this problem, there is still limited understanding of how pain management can be improved within the ED. This systematic mixed studies review aims to identify and critically synthesise research exploring staff views of barriers and enablers to pain management to understand why pain continues to be undertreated in the ED.MethodsWe systematically searched five databases for qualitative, quantitative and mixed methods studies reporting ED staff views of barriers and enablers to pain management in the ED. Studies were quality assessed using the Mixed Methods Appraisal Tool. Data were extracted and qualitative themes were generated by deconstructing data then developing interpretative themes. Data were analysed using convergent qualitative synthesis design.ResultsWe identified 15 297 articles for title/abstract review, reviewed 138 and included 24 in the results. Studies were not excluded due to low quality, although lower scoring studies contributed less data to the analysis. Quantitative surveys focused more on environmental factors (eg, high workload and bureaucratic restrictions), while qualitative studies revealed more insight about attitudes. We developed five interpretative themes from the thematic synthesis: (1) pain management is seen as important but not a clinical priority; (2) staff do not recognise the need to improve pain management; (3) the ED environment makes it difficult to improve pain management; (4) pain management is based on experience, not knowledge; and (5) staff lack trust in the patient’s ability to judge pain or manage it appropriately.ConclusionsOverly focusing on environmental barriers as principal barriers to pain management may mask underlying beliefs that hinder improvements. Improving feedback on performance and addressing these beliefs may enable staff to understand how to prioritise pain management.
What can death records tell us about multimorbidity?
Authors: Baneshi Mohammad Reza , Eynstone-Hinkins James , McElwee Paul , Mishra Gita D , Moran Lauren , Waller Michael , Dobson Annette 
Published: June 2023

BackgroundMultimorbidity has been measured from many data sources which show that prevalence increases with age and is usually greater among women than men and in more recent periods. Analyses of multiple cause of death data have shown different patterns of multimorbidity associated with demographic and other characteristics.MethodsDeaths in Australia among over 1.7 million decedents aged 55+ were stratified into three types: medically certified deaths, coroner-referred deaths with natural underlying causes and coroner-referred deaths with external underlying causes. Multimorbidity was measured by prevalence of ≥2 causes and analysed over three periods based on administrative changes: 2006–2012, 2013–2016 and 2017–2018. Poisson regression was used to examine the influence of gender, age and period.ResultsThe prevalence of deaths with multimorbidity was 81.0% for medically certified deaths, 61.1% for coroner-referred deaths with natural underlying causes and 82.4% for coroner-referred deaths with external underlying causes. For medically certified deaths, multimorbidity increased with age: incidence rate ratio (IRR 1.070, 95% CI 1.068, 1.072) was lower for women than men (0.954, 95% CI 0.952, 0.956) and changed little over time. For coroner-referred deaths with natural underlying causes, multimorbidity showed the expected pattern increasing with age (1.066, 95% CI 1.062, 1.070) and being higher for women than men (1.025, 95% CI 1.015, 1.035) and in more recent periods. For coroner-referred deaths with external underlying causes, there were marked increases over time that differed by age group due to changes in coding processes.ConclusionDeath records can be used to examine multimorbidity in national populations but, like other data sources, how the data were collected and coded impacts the conclusions.
Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy
Authors: Desai Aakash P , Kosari Farhad , Disselhorst Maria , Yin Jun , Agahi Alireza , Peikert Tobias , Udell Julia , Johnson Sarah H , Smadbeck James , Murphy Stephen , Karagouga Giannoula , McCune Alexa , Schaefer-Klein Janet , Borad Mitesh J , Cheville John , Vasmatzis George , Baas Paul , Mansfield Aaron 
Published: June 2023

BackgroundImmune checkpoint inhibitors (ICIs) are now a first-line treatment option for patients with pleural mesothelioma with the recent approval of ipilimumab and nivolumab. Mesothelioma has a low tumor mutation burden and no robust predictors of survival with ICI. Since ICIs enable adaptive antitumor immune responses, we investigated T-cell receptor (TCR) associations with survival in participants from two clinical trials treated with ICI.MethodsWe included patients with pleural mesothelioma who were treated with nivolumab (NivoMes,NCT02497508) or nivolumab and ipilimumab (INITIATE,NCT03048474) after first-line therapy. TCR sequencing was performed with the ImmunoSEQ assay in 49 and 39 pretreatment and post-treatment patient peripheral blood mononuclear cell (PBMC) samples. These data were integrated with TCR sequences found in bulk RNAseq data by TRUST4 program in 45 and 35 pretreatment and post-treatment tumor biopsy samples and TCR sequences from over 600 healthy controls. The TCR sequences were clustered into groups of shared antigen specificity using GIANA. Associations of TCR clusters with overall survival were determined by cox proportional hazard analysis.ResultsWe identified 4.2 million and 12 thousand complementarity-determining region 3 (CDR3) sequences from PBMCs and tumors, respectively, in patients treated with ICI. These CDR3 sequences were integrated with 2.1 million publically available CDR3 sequences from healthy controls and clustered. ICI-enhanced T-cell infiltration and expanded T cell diversity in tumors. Cases with TCR clones in the top tertile in the pretreatment tissue or in circulation had significantly better survival than the bottom two tertiles (p<0.04). Furthermore, a high number of shared TCR clones between pretreatment tissue and in circulation was associated with improved survival (p=0.01). To potentially select antitumor clusters, we filtered for clusters that were (1) not found in healthy controls, (2) recurrent in multiple patients with mesothelioma, and (3) more prevalent in post-treatment than pretreatment samples. The detection of two-specific TCR clusters provided significant survival benefit compared with detection of 1 cluster (HR<0.001, p=0.026) or the detection of no TCR clusters (HR=0.10, p=0.002). These two clusters were not found in bulk tissue RNA-seq data and have not been reported in public CDR3 databases.ConclusionsWe identified two unique TCR clusters that were associated with survival on treatment with ICI in patients with pleural mesothelioma. These clusters may enable approaches for antigen discovery and inform future targets for design of adoptive T cell therapies.