bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between spino-pelvic alignment and primary dysmenorrhea
Authors: Wang Juehan , He Xin , Zhu Ce , Ding Hong , Feng Ganjun , Yang Xi , Liu Limin , Song Yueming 
Published: February 2023

IntroductionMost women of reproductive age suffered from the primary dysmenorrhea (PD). Up to date, most studies on the etiology of dysmenorrhea focused on endocrine factors while ignored the effect of spino-pelvic bony anatomy on uterus. In this study, we innovatively shed light on the relationship between primary dysmenorrhea and sagittal spino-pelvic alignment.Materials and Methods120 patients diagnosed with primary dysmenorrhea and a control group of 118 healthy volunteers were enrolled into this study. All subjects received the standing full-length posteroanterior plain radiography to evaluate the sagittal spino-pelvic parameters. The visual analog scale (VAS) was used to assess pain rating of primary dysmenorrhea patients. Analysis of variance (ANOVA) or Student's t test was performed to measure statistical significance between differences.ResultsThere was a significant difference in pelvic incidence (PI), sacral slope (SS), lumbar lordosis (LL) and thoracic kyphosis (TK) between PD group and Normal group (P&lt;0.05). Furthermore, in PD group, the PI and SS was significant different between mild pain group and moderate pain group (P&lt;0.05) and there was a significant negative correlation between pain rating and SS. From the perspective of sagittal spinal alignment, the majority of PD patients were classified with Roussouly type 2, meanwhile most normal people were classified with Roussouly type 3.ConclusionSagittal spino-pelvic alignment was related to primary dysmenorrhea symptoms. Lower SS and PI angles may contribute to a worsen pain in PD patients.
Telehealth‘s future in Australian primary health care: a qualitative study exploring lessons learnt from the COVID-19 pandemic
Authors: Ashley Christine , Williams Anna , Dennis Sarah , McInnes Susan , Zwar Nicholas A , Morgan Mark , Halcomb Elizabeth 
Published: February 2023

BackgroundDuring the COVID-19 pandemic, telehealth emerged as a means of safely providing primary healthcare (PHC) consultations. In Australia, changes to telehealth funding led to the reconsideration of the role of telehealth in the ongoing provision of PHC services.AimTo investigate GPs’, registered nurses‘ (RNs), nurse practitioners‘ (NPs), and allied health (AH) clinicians perceptions of the sustainability of telehealth in PHC post-pandemic.Design & settingSemi-structured interviews were undertaken with 33 purposively selected clinicians, including GPs (n= 13), RNs (n= 5), NPs (n= 9), and AH clinicians (n= 6) working in PHC settings across Australia. Participants were drawn from responders to a national survey of PHC providers (n= 217).MethodThe thematic analysis approach reported by Braun and Clarke was used to analyse the interview data.ResultsData analysis revealed that the perception of providers was represented by the following two themes: lessons learnt; and the sustainability of telehealth. Lessons learnt included the need for rapid adaptation to telehealth, use of technology, and the pandemic being a catalyst for long-term change. The sustainability of telehealth in PHC comprised four subthemes around challenges: the funding model, maintaining patient and provider safety, hybrid service models, and access to support.ConclusionProviders required resilience and flexibility to adapt to telehealth. Funding models must reward providers from an outcome focus, rather than placing limits on telehealth’s use. Hybrid approaches to service delivery will best meet the needs of the community but must be accompanied by support and education for PHC professionals.
L’arco di Ulisse. Osservazioni sul riconoscimento dell’eroe
Authors: Cucuzza Nicola , Mari Francesco 
Published: February 2023

L’articolo esamina i modi in cui, nell’Odissea, avviene il riconoscimento di Ulisse. L’analisi dei dati testuali ed il loro confronto con la documentazione archeologica dell’Egeo fra Tardo Età del Bronzo e Antica Età del Ferro, in particolare, permettono di cogliere alcuni interessanti aspetti dell’episodio della gara del canto XXI, al termine della quale l’eroe uccide i Proci. L’arco, infatti, presenta una simbologia complessa su piani diversificati : arma da caccia,
avatar di Penelope, “ doppio” della cetra e, in quanto tale, attributo della regalità.
INFLUENCE OF ROSUVASTATIN ON VASCULAR ENDOTHELIUM FUNCTIONAL STATE AND SYSTEMIC INFLAMMATION IN PATIENTS WITH ISCHEMIC HEART DISEASE AND DIABETES MELLITUS
Authors: Fushtey I. M. , Podsevahina S. L. , Palamarchuk O. I. , Tkachenko O. V. , Kulinich I. A. 
Published: February 2023

Purpose of the study. The goal of the present study was to evaluate the effect of low dosed statins (rosuvastatin 10 mg/day) on the state of lipid and carbohydrate metabolism, insulin levels, vascular endothelial function, and markers of systemic inflammation in patients with ischemic heart disease in combination with diabetes mellitus.
Materials and research methods. We examined 83 patients with ischemic heart disease and type 2 diabetes mellitus aged 44 to 78 years (mean age was (56,8 ± 3,4) years). For all patients, the fasting glucose level was determined, the HOMA index, the levels of total cholesterol, low density lipoproteins, very low density lipoproteins, high density lipoproteins and triglycerides in the blood, the concentration of C-reactive protein, and the content of pro-inflammatory cytokines in the blood serum were calculated. To study the function of the endothelium, dopplerography of the brachial artery was used according to the D.S. Celermajer. All patients received IHD therapy according to generally accepted standards. The drugs were used against the background of stable oral hypoglycemic therapy. As cholesterol-lowering therapy, rosuvastatin was prescribed at a dose of 10 mg/day for 3 months.
Results. During the study, it was noted that in patients with coronary artery disease in combination with type 2 diabetes mellitus on the background of hyperand dyslipidemia, elevated levels of insulin and glucose, dysfunction of the vascular endothelium was revealed. Vascular endothelial dysfunction had a close correlation with markers of systemic inflammation, which was exacerbated by the presence of insulin resistance. While taking rosuvastatin at a dose of 10 mg/day, in addition to a sufficient lipid-correcting effect, there was a decrease in the level of IR, activity of systemic inflammation and improvement in the function of the vascular endothelium, which ensures the correction of additional risk factors in patients with coronary artery disease in combination with type 2 diabetes.
Conclusions. In patients with ischemic heart disease in combination with type 2 diabetes mellitus on the background of hyperand dyslipidemia, elevated levels of insulin and glucose, dysfunction of the vascular endothelium was revealed. Dysfunction of the vascular endothelium is closely correlated with markers of systemic inflammation, which is exacerbated by the presence of insulin resistance. Against the background of taking rosuvastatin at a dose of 10 mg/day, in addition to a sufficient lipid-correcting effect, a decrease in the level of IR, activity of systemic inflammation and an improvement in the function of the vascular endothelium were noted, which ensures the correction of additional risk factors in patients with coronary artery disease in combination with type 2 diabetes.
LEVEL SELECTION OF NON-TRAUMATIC LOWER EXTREMITY AMPUTATIONS IN PATIENTS WITH CRITICAL ISCHEMIA
Authors: Vasyliuk S. M. , Osadets V. S. , Prudnikov O. V. , Makarchuk O. M. , Krysa B. V. , Ivanyna V. V. 
Published: February 2023

Objective. To evaluate the informativeness of ultrasound scanning of the lower limb arteries and angiography in patients with critical ischemia for choosing the optimal level of extremity amputation.
Methods. Treatment of 289 patients with obliterative diseases of the arteries of the lower extremities of various genesis with the indications for amputation of the damaged lower extremity was analyzed.
Results. Ultrasound scanning of arteries could not always characterize the severity of collateral circulation, but indicated only the level of occlusion. However, the severity of chronic ischemia of the lower limb is determined not only by the level of occlusion, but also by the severity of collateral blood flow at the same level of damage. That is why, in our opinion, the results of an ultrasound examination of the lower limb arteries cannot be decisive when choosing the level of amputation. Angiography made it possible to characterize not only the level of occlusion or stenosis, but also the state of collateral circulation, which had a decisive influence on the choice of the method of limb amputation.
Conclusion. Ultrasound examination of the lower extremity vessels allows to establish the level of occlusion, but is uninformative for the assessment of collateral anastomoses, which is an important factor in choosing the level of non-traumatic amputation of the lower extremity. In patients with critical ischemia, transtibial amputations should be avoided, as they show worse results. The operation of choice should be a transfemoral amputation or non-traumatic through-knee amputation.
The state of the immune system in patients with functional ovarian cysts
Authors: Shapoval O. S. , Vorontsova L. L. 
Published: February 2023

Conducting a qualitative and comprehensive examination of patients with functional ovarian cysts is fundamentally necessary to understand the treatment strategy of this pathological state.
The objective of the work was to study the features of immune disorders in patients of reproductive age with functional ovarian cysts.
Methods. 50 patients of reproductive age with functional ovarian cysts were examined. General clinical, gynecological, ultrasound examination of the pelvic organs, a study of the state of the immune system were carried out.
Results. In 70% of patients chronic inflammatory processes of the pelvic organs were detected. The findings revealed varying degrees of immune system disorders in women with ovarian cysts with different parity.
In nulliparous and women who gave birth violations of cell immunity of the I degree were revealed, in the group with infertility - II degree.
In the group of patients who gave birth and with infertility, the III degree of disorders of humoral immunity was diagnosed, and in nulliparous women - II degree.
Conclusion. Determining the degree of disorders of the immune system already at the prehospital stage will allow individualizing the choice and dosing regimen of immunomodulatory drugs as part of the complex therapy of functional ovarian cysts.
EFFECTIVENESS OF HORMONAL TREATMENT IN PATIENTS WITH COMBINED ENDOMETRIAL PATHOLOGY AND BENIGN FORMATIONS OF MAMMARY GLANDS
Authors: Shapoval Yu. S. 
Published: February 2023

Issues related to the treatment of HPE are still very relevant, which is due to the high frequency of relapses of this disease. Today, in the arsenal of modern medicine, there are various approaches to the treatment of HPE. However, the development of benign neoplasms of the mammary glands against the background of HPE limits the possibilities of conservative treatment. Hormonal therapy remains one of the most common methods of treating HPE.
The purpose of the study: to optimize the treatment of patients with various types of hyperplastic processes of the endometrium in combination with benign diseases of the mammary glands.
Materials and methods. A prospective study of 90 women aged 18 to 47 was conducted. The main group consisted of patients who were diagnosed with HPE and benign diseases of the mammary glands. The comparison group included patients who were diagnosed with HPE without accompanying pathology of the mammary glands. For the treatment of endometrial hyperplasia without atypia, medroxyprogesterone was used, for the treatment of atypical endometrial hyperplasia, medroxyprogesterone was used in combination with a gonadotropin-releasing hormone analog. For the treatment of patients with combined pathology, the commercial drug Danazol or medroxyprogesterone in combination with Koberlin was used.
The results. The implementation of various treatment regimens for patients with HPE and benign breast neoplasms showed that the more effective treatment regimen was the one involving the use of Danazol. In this group of patients, the levels of estradiol and progesterone in the blood plasma normalized already after six months of using the drug.
Conclusion. The study of the levels of estrogens, progestins and gonadotropic hormones showed that in the patients of the comparison group, the best treatment scheme is the combined use of medroxyprogesterone and gonadotropin-releasing hormone analogues compared to the monouse of only medroxyprogesterone. In patients with the combined pathology of HPE and mastopathy, the best treatment scheme is the use of Danazol.
COMPLEX TREATMENT OF COMPLICATED FORMS OF ERYSIPELAS
Authors: Syplyviy V. O. , Dotsenko V. V. , Ievtushenko D. V. , Ievtushenko O. V. , Kolotilov O. V. 
Published: February 2023

Summary. Objectives: to analyze the immediate results of the complex treatment of complicated forms of erysipelas.
Methods: A retrospective analysis of the immediate results of complex treatment of 67 patients with complicated forms of erysipelas was conducted. There were 29 (43.3%) men, 38 (56.7%) women. The average age was 65.1 years.
Results: The duration of symptoms of the disease before hospitalization varied from 3 to 14 days. The erythematous form of erysipelas was found in 7 (10.5%), erythematous-hemorrhagic – in 14 (20.9%), erythematous-bullous – in 21 (31.3%), bullous-hemorrhagic – in 25 (37.3 %). According to the localization, erysipelas of the head was found in 5 (7.5%), upper limbs - in 3 (4.5%), lower limbs - in 59 (88%). Primary erysipelas was present in 39 (58.2%), recurrent – in 28 (41.8%). In the picture of peripheral blood, leukocytosis is determined with a shift of the leukocyte blood formula to the left. The level of C-reactive protein is 18 - 100 times higher than the upper limit of normal. According to the results of cultures of scrapings of affected tissues, the dominance of Staphyloccus haemolyticus in associations with other gram-positive and gram-negative microorganisms was revealed. High polyresistance of Staphyloccus haemolyticus strains to antibacterial drugs with preservation sensitivity to Clindamycin, Vancomycin, Linezolid, and Teicoplatin was inserted.
Conclusions: Complicated forms of erysipelas are found in 89.5% of patients who are being treated in the surgical department for erysipelas. The most frequent localization is erysipelas of the lower limbs, which is found in 88%. Staphylococcus haemolyticus is dominant among the causative agents of erysipelas in various associations with other gram-positive and gram-negative microorganisms. A high polyresistance of Staphylococcus haemolyticus strains to antibacterial drugs is determined, while sensitivity to clindamycin, vancomycin, linezolid, and teicoplanin is preserved. Treatment of erysipelas is complex, including antibacterial therapy, surgical treatment of complications, local treatment of wounds, drug corrective therapy of concomitant chronic pathology.
Examining the Fourth Grade Turkish Textbook and Classroom Teachers’ In-class Practices in Vocabulary Teaching
Authors: BOYACI ALTINAY Yasemin , AKYOL Hayati 
Published: February 2023

This study was conducted to identify the activities aimed at improving vocabulary included
in the fourth grade Turkish course and textbook, the opinions of classroom teachers in this
regard, the strategies, practices and activities they used for this purpose, and the time they
spent on this in the teaching-learning process. The research was carried out as a case study,
one of the qualitative research designs. In the data collection process of this study, an
activity identification table was used for examining the Turkish textbook, a structured
observation form was used for classroom observations, and a semi-structured interview
form was used for interviews with the participants. Descriptive analysis and content
analysis techniques were used for data analysis. As a result of the study, it was determined
that the distribution of activities in the textbook, which is acknowledged as one of the
important tools for supporting the development of vocabulary, varied depending on basic
language skills. It was concluded that in the Turkish course teaching process, teachers
included 14 different activities related to vocabulary instruction, using 19 different
methods, techniques and strategies, in line with the textbook. The results obtained from the
observations and interviews revealed that teachers did not have adequate knowledge about
the methods, techniques and strategies that they used to improve vocabulary, and that
therefore, they were unable to appropriately use the implementation steps required for the
strategies.
TANGGUNGJAWAB SOSIAL DAN LINGKUNGAN KORPORASI MENGATASI KONFLIK DENGAN MASYARAKAT LOKAL DALAM PEMANFAATAN SUMBER DAYA AIR DI INDONESIA
Authors: Maria Magdalena Blegur  , R. Ismala Dewi  
Published: February 2023

Reflecting on these regimes, they often experience competition to trigger conflicts over water use. Regarding the existence of a water company in Sukamantri Village, West Java, exposing relation between corporate social and environmental responsibilities related to the exploitation of water resources by the Company in one hand, and the declining quality of water resources on the other. The method used in this context is to analyze the content of legal texts regarding the initial purpose in relation to the content of legal texts and their impact by paying attention to the supporting literature. The analysis is carried out using a qualitative approach through normative juridical approach. The analysis of water resources exploitation by the Company related to corporate social and environmental responsibility are needed as well as regulating substances related to corporate social and environmental responsibility, especially regarding the provisions on legal sanctions, namely the elimination or reduction of incentives of Company. So that the State-Owned Enterprise Company and a Private-Owned Enterprise engaged in the utilization of water resources is obliged to maintain and preserve the environment.
Implementasi PLC Outseal Untuk Mengendalikan Tegangan Keluaran AC-AC Konverter
Authors: Lucky Fernando Soleman Beferlly , Heru Pratomo Leonardus , Wibisono Arifin 
Published: February 2023

Programmable Logic Controller (PLC) merupakan unit pengendali pusat pada industri. terdiri dari dari Central Processing Unit (CPU), memori serta modul Input I Output untuk mengatur data input I output. Selain itu, PLC dalam dunia otomasi i1ndustri juga dikenal istilah mikrokontroler yang beroperasi pada tegangan kecil berkisar 7-24 Volt dimana arus input dan output 7-24 mA. PLC Outseal merupakan inovasi baru dengan memanfaatkan Arduino sebagai CPU dan dikembangkan dengan menambahkan pin input. output, input ADC dan berbagai fungsi yang dapat digunakan sebagaimana mestinya PLC berfungsi. PLC Outseal dikendalikan dengan program melalui Outseal Studio berupa ladder diagram dengan berbagai fungsi di dalamnya seperti fungsi pembangkit Pulse Width Modulation (PWM). fungsi logika. fungsi pengatur waktu dan masih banyak lagi. Kelebihan dari PLC Outseal ini dalam mengendalikan sinyal PWM yaitu dapat di program dengan mudah. Cukup menambahkan fungsi skala sinyal PWM yang diinginkan. kemudian menentukan frekuensi yang diinginkan dan mengatur duty cycle memanggil pin input ADC. Pada makalah ini membahas tentang pemanfaatan PLC Outseal untuk mengatur cahaya pada lampu penerangan jalan umum (PJU) dengan beberapa tingkat penerangan berbasis PWM. Jenis lampu yang digunakan yaitu PJU Street Light 50W dengan tegangan AC 85-265¥ untuk penelitian ini. Sehingga dibutuhkan suatu konvener AC ke AC untuk menghidupkan lampu tersebut. Converter ini diimplementasikan dengan sebuah driver.
Model Digital Marketing Terintegrasi UMKM melalui Aplikasi untuk Optimalisasi Pemasaran Produk Tanaman Biofarmaka
Authors: Hiswati Marselina Endah , Wanda Putra , Ordiyasa I Wayan , Utami Lila Retnani 
Published: February 2023

Kabupaten Sleman memiliki sekitar lebih dari 50 pasar tradisional dan juga adanya keragaman sektor usaha UMKM serta terdapat lebih dari 18.293 sektor usaha akomodasi, makanan, dan minuman yang sedang berkembang. Bentuk upaya optimalisasi promosi produk-produk UMKM Kabupaten Sleman di masa pandemic dan pasca pandemic nantinya, diperlukan inovasi baru untuk meningkatkan promosi dan pemasaran produk-produk UMKM di Sleman. Optimalisasi UMKM termasuk melalui peningkatan transaksi di pasar tradisional menjadi fokus Kabupaten Sleman, sesuai Rencana Pembangunan Jangka Menengah Daerah (RPJMD) Kabupaten Sleman.
Teknologi informasi berbasis mobile sangat diperlukan sebagai media yang mendukung upaya promosi dan pemasaran produk UMKM, khususnya kuliner tradisional dalam hal ini produk hasil olahan tanaman Biofarmaka, serta menjadi peluang dalam mengatasi kemiskinan. Adanya kebijakan pembatasan sosial akibat pandemi COVID-19 menuntut masyarakat untuk mengenali teknologi sebagai media sosialisasi kearah digitalisasi.
Data hasil survei dan wawancara ke beberapa UMKM di Sleman, selama pandemi pengenalan produk kuliner telah dilakukan dengan memanfaatkan sosial media, seperti instagram, facebook, whatsapp, namun hal ini dianggap kurang terintegerasi. Sehingga, diperlukan satu aplikasi berbasis mobile sebagai wadah tempat bertemunya para penjual dan pembeli yang dikhususkan untuk produk lokal Sleman. Harapannya inovasi ini memiliki dampak pada peningkatan pendapatan dan perekonomian pelaku UMKM.
Inovasi ini sangat diperlukan sebagai media yang mendukung upaya pemasaran yang inovatif untuk produk UMKM, serta menjadi upaya pemberdayaan masyarakat dalam menciptakan ekonomi yang produktif berbasis inovasi teknologi. Inovasi digital memiliki dampak pada peningkatan pendapatan dan perekonomian pelaku UMKM di Kabupaten Sleman, Daerah Istimewa Yogyakarta.
PENGARUH SUHU PENYIMPANAN KOMBINASI AMOKSISILIN DAN ASAM KLAVULANAT DALAM SEDIAAN DRY SIRUP TERHADAP DAYA HAMBAT BAKTERI (Staphylococcus aureus)
Authors: . Muhamad Taswin , Astuti Ratnaningsih Dewi , Handayani Bherta Tiara 
Published: February 2023

Sediaan dry sirup kombinasi amoksisilin dan asam klavulanat merupakan obat pilihan pertama untuk pengobatan penyakit infeksi seperti pneumonia. Sediaan dry sirup kombinasi amoksisilin dan asam klavulanat merupakan sediaan antibiotik yang perlu disuspensikan terlebih dahulu sebelum digunakan. Suhu penyimpanan dan stabiltas zat aktif didalam sediaan sangatlah penting karena dengan adanya penambahan air didalam sediaan suspensi kombinasi amoksisilin dan asam klavulanat akan mempengaruhi degradasi kimiawi, fisik dan mikrobiologi. Penelitian ini bertujuan untuk mengukur adanya pengaruh suhu penyimpanan kombinasi amoksisilin dan asam klavulanat dalam sediaan dry sirup yang telah disuspensikan terhadap daya hambat bakteri Staphylococcus aureus. Jenis penelitian ini adalah penelitian eksperimental karena adanya perlakuan terhadap sediaan antibiotik kombinasi amoksisilin dan asam klavulanat yang dipengaruhi oleh suhu penyimpanan terhadap aktivitas antibakteri. Berdasarkan hasil pengukuran diameter daya hambat pada antibiotik suspensi kombinasi amoksisilin dan asam klavulanat pada penyimpanan hari ke-7 semua sampel suspensi dry sirup mengalami penurunan. Penurunan diameter zona hambat tertinggi terjadi pada sampel suspensi dry sirup generik yang disimpan pada suhu kamar. Dari hasil penelitian dapat disimpulkan bahwa adanya pengaruh suhu penyimpanan kombinasi amoksisilin dan asam klavulanat dalam sediaan dry sirup terhadap daya hambat bakteri Staphylococcus aureus dengan adanya penurunan daya hambat di akhir penyimpanan