bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Impact of Distance Traveled and Birth Volumes of Hospital Maternity Units on Newborn Outcomes: Population-Based Cohort Study
Authors: Cantarutti Anna , Boracchini Riccardo , Bellù Roberto , Ronco Raffaella , Rea Federico , Locatelli Anna , Zanini Rinaldo , Corrao Giovanni 
Published: January 2025

Abstract

Background
The centralization of childbirth and newborn care in large maternity units has become increasingly prevalent in Europe. While this trend offers potential benefits such as specialized care and improved outcomes, it can also lead to longer travel and waiting times, especially for women in rural areas.

Objective
This study aimed to evaluate the association between hospital maternity unit (HMU) volumes, road travel distance (RTD) to the hospital, and other neonatal outcomes.

Methods
We conducted a population-based cohort study including all live births in hospitals without intensive care units between 2016 and 2019 in the Lombardy region, Italy. Given the hierarchical structure of our data (births nested within hospitals), we employed log-binomial regression models with random intercepts to estimate relative risks and 95% CIs for evaluating the association between HMU volumes (≥1500 births/year) and RTD (<5 km) with the risk of being transferred and/or death after birth (primary outcome). Secondary outcomes included a low Apgar score at 5 minutes and low adherence to antenatal care (ANC). We controlled for several potential confounders including adherence to the ANC pathway for the primary and low Apgar outcomes. To explore the influence of HMU volumes on the primary outcome, we identified the fractional polynomial model that best described this relationship.

Results
Of 65,083 live births, 71% (n=45,955) occurred in low-volume hospitals (<1000 births/year), 21% (n=13,560) involved long-distance travel (>15 km), 1% (n=735) were transferred and/or died after birth, 0.5% (n=305) had a low Apgar score at 5 minutes, and 64% (n=41,317) completely adhered to ANC. The risk of transfer and/or death increased as HMU volume decreased, ranging from 1% for hospitals with 1000‐1500 births/year to a 3.6-fold high risk for hospitals with <500 births/year (compared to high-volume hospitals). Travel distance did not affect the primary outcome. Neither HMU volume nor RTD were associated with low Apgar scores. Conversely, the risk of complete adherence to ANC decreased with lower HMU volumes but increased with shorter RTD. Additionally, high-volume hospitals demonstrated a decreasing trend in the frequency of the primary outcome, with transfer and/or death rates ranging from 2% to 0.5% and flattening to 0.5% in hospitals, with activity volume ≥1000 mean births/year.

Conclusions
Our findings showed an excess risk of neonatal transfer and/or death for live births in HMUs with low activity volumes without an intensive care unit. In contrast, RTD primarily affected adherence to ANC. Moreover, data suggest that 1000 births/year could be an optimal cutoff for maternity hospitals to ensure an appropriate standard of care at delivery.
Impact of Attached File Formats on the Performance of ChatGPT-4 on the Japanese National Nursing Examination: Evaluation Study
Authors: Taira Kazuya , Itaya Takahiro , Yada Shuntaro , Hiyama Kirara , Hanada Ayame 
Published: January 2025

Abstract
This research letter discusses the impact of different file formats on ChatGPT-4’s performance on the Japanese National Nursing Examination, highlighting the need for standardized reporting protocols to enhance the integration of artificial intelligence in nursing education and practice.
Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference for Patients With Obesity or Overweight: A Systematic Review, Meta-analysis, and Meta-regression of 47 Randomized Controlled Trials
Authors: Wong Hon Jen , Sim Bryan , Teo Yao Hao , Teo Yao Neng , Chan Mark Y. , Yeo Leonard L.L. , Eng Pei Chia , Tan Benjamin Y.Q. , Sattar Naveed , Dalakoti Mayank , Sia Ching-Hui 
Published: January 2025

OBJECTIVE
To provide an updated synthesis on effects of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on weight, BMI, and waist circumference incorporating newer randomized controlled trials (RCTs), particularly in individuals with overweight or obesity.

RESEARCH DESIGN AND METHODS
We systematically searched PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs published from inception to 4 October 2024. The search was limited to RCTs evaluating the use of GLP-1 RAs for mean differences from baseline in weight, BMI, and waist circumference in adults with obesity or overweight with or without diabetes. Two independent reviewers performed the literature search and data extraction, resolving disagreements via consensus or third-reviewer consultation.

RESULTS
Forty-seven RCTs were included, with a combined cohort of 23,244 patients. GLP-1 RAs demonstrated a mean weight reduction of −4.57 kg (95% CI −5.35 to −3.78), mean BMI reduction of −2.07 kg/m2 (95% CI −2.53 to −1.62), and mean waist circumference reduction of −4.55 cm (95% CI −5.72 to −3.38) compared with placebo. This effect was consistent across diabetes status, GLP-1 RA used, and route of administration. The greatest treatment benefit appeared to favor patients who were younger, female, without diabetes, with higher baseline weight and BMI but lower baseline HbA1c, and treated over a longer duration. Limitations include substantial statistical heterogeneity, in part due to broad inclusion criteria. However, this heterogeneity may improve generalizability by reflecting a wide range of study designs and patient populations.

CONCLUSIONS
GLP-1 RAs demonstrated significant weight, BMI, and waist circumference reduction benefits in this meta-analysis.
Preserving Secrecy in the Frame of Labour Relationships: Methods of Secrets Protection, Analysis of the Problems and Proposals to Improve the Legislation
Authors: Smolenskiy M. B. 
Published: January 2025

Introduction. The large-scale transformations in the state power and governance authorities of the Russian Federation have led to the significant change of the role assigned to the legal and state institutions. The reforms have also affected the matters related to the protection of various types of secrets in the frame of labour relationships, organisation of the work of the human resources departments and their interaction with the law enforcement and regulatory authorities. The authors as well as other scientists study the various viewpoints on this issue, however, neither in the scientific nor in the law enforcement circles there exists a uniform opinion on the methodology of protecting the secrets. The aim of this study is to investigate the existing methods of protecting the secrets, to identify the problematic aspects in the system of interaction between the state, law enforcement and judicial bodies of the Russian Federation and to propose possible solutions for improving the methods of preserving secrecy at the current stage of development of the country.Materials and Methods. The general scientific and specific scientific methods were used in the frame of the study, such as, the dialectical method of cognition, the cognitive analysis method, the sociological method and others.Results. When carrying out the certain actions under the employment contract, an employer and an employee are guided by the special rules, which correspond to a specific secrecy preserving behaviour, but which, in the author’s opinion, are not enough accurate and worked out in the acting legislation of the Russian Federation. The main problems referring to this subject are: the insufficiently developed theoretical apparatus; a narrow range of powers in the frame of the state supervision; low level of administrative liability of the subjects. To solve these problems, a number of measures are proposed to optimize the legal support of the parties of the employment contract in the frame of protecting their rights and freedoms and providing them with the guarantees necessary to ensure the regime of preserving secrecy.Discussion and Conclusion. To ensure the efficient legal policy of the state, the constant improvement of the legal framework is required. The present article investigates in detail the problems of organising the interaction of both the state and private employers with the law enforcement and judicial authorities of the Russian Federation in the frame of implementing the methods of secrecy preservation, and the ways of solving these problems are proposed. The main conclusions made by the author have theoretical and practical significance for further research in this field.
Influencia del Tipo de Alcalinizante Sobre el Proceso de Estabilización Química del Agua Tratada en Plantas de Tratamiento Convencional
Authors: Pérez-Vidal Andrea , Gutiérrez-Zapata Héctor Mario , Delgado-Cabrera Luis Germán , Vidal-Guerrero Alex Javier , Ramírez-Medina Lina María , Porras-Castro Christian Felipe , Escobar-Rivera Juan Carlos , Ospina-Rodríguez Juliana , Gutierrez-Marín Juan Pablo , Torres-Lozada Patricia 
Published: January 2025

Los bajos niveles de alcalinidad en las fuentes de abastecimiento superficial, aunado al uso de coagulantes y desinfectantes en el tratamiento convencional del agua para consumo humano, que en general consumen alcalinidad y reducen el pH, hacen necesario realizar ajustes en la calidad del agua tratada con el fin de garantizar su estabilización química y prevenir contaminación secundaria en el sistema de distribución de agua potable (SDA) por problemas de corrosión o incrustaciones. En este estudio se revisó la literatura sobre características de diferentes alcalinizantes y posteriormente se evaluó mediante ensayos de pruebas de jarras la estabilización química del agua, previamente desinfectada, de una planta de tratamiento de agua potable – PTAP convencional abastecida con agua cruda del río Cauca; se evaluaron dos condiciones de calidad de agua, previamente tratada y desinfectada, con pH inicial de 5,60 y 3,98 unidades respectivamente (asociadas a agua cruda con turbiedad de 30 y 200 UNT, respectivamente). Se evaluaron cinco alternativas: tres de alcalinización simple (Ca(OH)2, NaOH, Na2CO3) y dos de doble alcalinización (Ca(OH)2+NaOH y Ca(OH)2+Na2CO3). En la doble alcalinización se dosificó Ca(OH)2 hasta alcanzar un pH cercano a 6,5-7,0 y posteriormente se adicionó NaOH o Na2CO3. En todos los casos se evaluaron valores de pH entre 7,04-8,96, y finalmente se determinaron los índices de agresividad (IA) y de saturación de Langelier (ISL). Se identificaron diferentes alternativas de alcalinizantes, cada una con ventajas y limitaciones y cuya selección dependerá, además de sus características químicas y la calidad del agua, de aspectos como costos, facilidad de adquisición, preparación y dosificación, tipo de materiales del SDA, entre otros. La evaluación experimental mostró que, tanto Ca(OH)2 como la doble alcalinización Ca(OH)2+Na2CO3, resultan viables para la estabilización química del agua analizada, lográndose aumentar la alcalinidad y la capacidad amortiguadora del agua, que favorece que el pH sea más estable en el SDA. Se destaca que la eficacia del Ca(OH)2 dependerá del contenido de CaO (>90%) y de una adecuada homogenización de la solución durante su dosificación. El ajuste del pH debe ser del orden de 8,7 a 8,9 para reducir la tendencia corrosiva del agua y permitiendo alcanzar valores cercanos a 12 y 0 de los índices IA e ISL respectivamente.
Modernización del Sistema de Diagnóstico Automático de Eventos en Líneas de Transmisión y Subtransmisión de Energía Eléctrica
Authors: Álvarez-Osorio David , Arenas-Crespo Oswaldo , Arregocés-Guerra Paulina , Rodríguez Suárez Juan Carlos , Tobar-Rosero Oscar A. , Zapata-Madrigal Germán D. 
Published: January 2025

En los sistemas eléctricos es fundamental contar con un correcto esquema de protección, en aras de garantizar estabilidad, seguridad y confiabilidad para los usuarios finales. Es así como al momento de ocurrencia de un evento en el Sistema de Transmisión de Energía se genera gran cantidad de información proveniente de los sistemas de control, relés de protección y registradores de fallas, que debe ser analizada en corto tiempo para la definición de acciones correctivas y la declaración de disponibilidad de los activos comprometidos en el evento. Contar con tiempos de respuesta adecuados para dichos procesos, le permite a una empresa tomar acciones efectivas y oportunas ante múltiples contingencias. Aquí juega un papel fundamental el diagnóstico automático de las fallas como una herramienta apoyada en tecnologías de inteligencia artificial (IA) que permiten tener tiempos de respuesta considerablemente bajos en comparación con los análisis operativos convencionales. En este documento se expone el desarrollo de una herramienta como perfeccionamiento de un aplicativo inicial para diagnóstico de eventos en líneas de transmisión y subtransmisión con diferentes niveles de tensión, identificando los modelos de IA que tienen mayor eficacia en el proceso de análisis y diagnóstico, exponiendo el proceso realizado desde la preparación de los datos hasta la validación de la herramienta y comparando los resultados obtenidos con el aplicativo llamado Diagnóstico Automático de Eventos (DAE), el cual, fue desarrollado por la propia empresa hace varios años y que se utiliza actualmente en los análisis operativos de las fallas. Los resultados obtenidos permiten identificar la alta eficacia del nuevo sistema DAE desarrollado y su aplicabilidad para análisis en líneas de transmisión con voltajes desde niveles de tensión de 34,5 kV hasta 500 kV.
Treatment, prognosis, and outcome of dogs treated for rectal plasmacytoma: a multicentric retrospective study
Authors: Jimeno Sandoval Juan Carlos , Cantatore Matteo , Meakin Lee , Menghini Timothy , Owen Laura , Doran Ivan , Erskine Matthew , Rossanese Matteo 
Published: January 2025

Abstract

OBJECTIVE
The aim of this study was to report the outcome and prognosis of canine patients treated medically or surgically for rectal plasmacytomas and to identify factors associated with recurrence, mortality, or progression to multiple myeloma.

METHODS
The databases of 7 referral hospitals were reviewed. The Kaplan-Meier method and Cox proportional hazards analysis were used to determine the association of a range of variables with recurrence and progression-free interval for the surgically treated patients.

RESULTS
20 dogs were included. Nineteen cases were treated surgically, and 1 case was treated conservatively (analgesia and monitoring). Metastatic lesions were detected in 2 of 20 dogs (10%). Four of 19 dogs (21%) treated surgically developed postoperative complications, 1 major (1 of 19 [5.2%]) and 3 minor (3 of 19 [15.8%]). Tumor recurrence was identified in 6 of 19 dogs (31.5%). The 1-, 2-, and 3-year survival rates were 95%, 72%, and 66%, respectively. None of the variables tested were associated with occurrence of complications. Increased distance from the anus, incomplete surgical margins, and decreasing surgeon experience were associated with an increased risk of recurrence. No progression to multiple myeloma was seen in any of the cases.

CONCLUSIONS
Surgical treatment of rectal plasmacytomas is associated with a low major complication rate and long survival. Metastasis and recurrence rates are significantly higher than previously reported.

CLINICAL RELEVANCE
Conservative surgery leads to long-term survival, but recurrence is common. Future studies should focus on the benefits of adjuvant treatments.
The age and genetics of individual larches in four rural parks and at the Järvselja Educational and Experimental Forest Centre in Estonia
Authors: Sander Heldur , Pâques Luc E. 
Published: January 2025

Abstract
The article investigates the historical presence and current status of larch trees within the parks of five former manors in South Estonia: Kastre and its Peravalla forest district (now Järvselja Educational and Experimental Forest Centre), Mäksa, Kabina and Mõniste. Before 1918, South Estonia was part of the province of Livonia in the Russian Empire. The analysis encompasses taxonomy, habitats and the introduction of various larch species. Selected larch trees within these parks were dated using dendrochronological methods. The research revealed a consistent pattern of larch tree planting over a century, occurring in seven distinct rounds between the 1820s (Kastre Park) and the 1940s (Järvselja) as follows: 1) 1820 and 1895 (Kastre), 2) 1907 and 1920–1940 (Järvselja), 3) 1825–1840 (Mõniste), 4) 1855–1865 (Kabina), and 5) 1870–1880 (Mäksa). Genetic characterization was applied to determine individual tree species based on morphometric determinations. The majority of larch trees within the parks were genetically confirmed as European larches, which was consistent to the morphological assessments conducted at Kastre, Järvselja and Mäksa. The analysis revealed that a younger, naturally propagated larch located at Kastre with morphological characteristics of European larch showed subtle genetic indicators of Japanese larch. The cause of this unexpected finding remains vague. It is hypothesized that this specific tree might represent a hybrid of European and Siberian larches, given its inclusion within a stand hosting both species in proximity. At Järvselja, the genetic method confirmed the morphological identification of four larches as Japanese and two as Dunkeld larches. Six Siberian larches (sensu lato) located at Kastre and Järvselja were genetically identified as hybrids of Japanese and European larches while the cause of this hybridization remains unclear. Utilization of genetic markers not validated for Russian (L. archangelica), Siberian (L. sibirica s. str.), and hybrid (L. decidua × L. sibirica and L. sibirica × L. decidua) larches makes the obtained results inconclusive. In the case of Mäksa, both morphological and genetic analyses confirmed the presence of Japanese and Euro-Japanese larches, which was previously confirmed. It is important to note that the classification of L. leptolepis × L. decidua proposed by Bobrov is considered incorrect. Trees displaying similar characteristics, especially older specimens, should be classified according to Bobrov’s description as L. decidua f. kaempferi or f. marschlinsii.
Pre-sowing treatment of acorns with gibberellic acid and N-hexanoyl-L-homoserine lactone induced changes in growth and hormonal balance of Quercus robur L. seedlings
Authors: Voytenko Lesya , Vasyuk Valentyna , Babenko Lidia , Shcherbatiuk Mykola , Romanenko Kateryna , Kosakivska Iryna V. 
Published: January 2025

Abstract
This study aimed to assess and compare the impact of priming with gibberellic acid (GA3) and N-hexanoyl-L-homoserine lactone (C6-HSL) on acorn germination, seedling growth, and the balance of endogenous phytohormones in 47-day-old seedlings of pedunculated oak (Quercus robur L.). We hypothesized that exogenous GA3 and C6-HSL induce changes in hormonal homeostasis, which activate the germination of acorns and growth of seedlings. Acorns were soaked for 24 hours in water (control) and solutions of gibberellic acid (50 mg/L) and C6-HSL (300 ng/ml). The dynamics and distribution of endogenous cytokinins, abscisic (ABA), indole-3-acetic (IAA), gibberellic (GA3 and GA4) and salicylic (SA) acid in 47-day-old seedlings' organs of Q. robur were analysed using HPLC-MS. Priming with GA3 solution resulted in 85.8% of acorn germination, surpassing the control by 24.6%, whereas priming with C6-HSL solution led to 93.4% germination, surpassing the control by 32.2%. GA3-primed plants (GA3+plants) showed enhanced shoot growth, while C6-HSL-primed (C6-HSL+plants) plants had intensive root development. GA3 also caused epicotyl shoot thickening. Both regulators increased cytokinins, mainly active zeatin forms, with pronounced changes in shoots under C6-HSL and in roots under GA3. ABA content increased in both GA3+ and C6-HSL+plants, with a more significant effect in the roots of C6-HSL+plants. Both regulators negatively impacted IAA accumulation, with GA3 exhibiting a more pronounced effect, causing IAA accumulation to shift from shoots to roots post priming, whereas IAA dominance occurred in the shoots of non-primed acorns (C-plants) and C6-HSL+plants. The total gibberellin content increased in primed seedlings, with GA4 accumulating in GA3+plants and GA3 in C6-HSL+plants, surpassing GA3+plants by 40.7%. GA3+plants exhibited decreased SA in roots, contrasting with increased SA in the roots of C6-HSL+plants. In conclusion, both growth regulators optimized acorn germination, induced changes in hormonal homeostasis and enhanced seedling growth, with increased root growth in C6-HSL plants and shoot growth in GA3 plants.
Degree of Acceptance of the BIS Model in the Mechatronics Course
Authors: García Javier Rossette , Martínez Gabriela Clemente , Hernández José Genaro González , Gámez Julio César Martínez 
Published: January 2025

Objective: To identify the areas of opportunity of the Bilingual International and Sustainable (BIS) model, starting from the subjects in formation: the students.

Theoretical Framework: It is based on the process of internationalization in vogue at the beginning of the new millennium due to the imperative need of the global economy to demand bilingual professionals. This became important during the six-year term of office of President Peña Nieto, and the UTs had to make the transition from the traditional model to the BIS model, involving curricular transformation, changes in the field of teaching, lack of infrastructure and continuity in the teaching of the lingua franca.

Method: This is a quantitative approach with an exploratory, non-experimental scope. The technique used was a Likert scale survey with three points, and the measuring instrument was an Excel database for analyzing the data, whose reliability was obtained by means of Cronbach's Alpha.

Results and Discussion: They emphasize that the students decided to study under the BIS modality without considering its implications, such as the lack of clarity of the mobility process and the need for more counselling for the assimilation of the lingua franca; on the other hand, they point out that the didactic teaching aids need to be updated. On the other hand, they were not 100% satisfied with this modality. Despite this, They are trained in a way that makes them competitive and eligible for priority consideration by employers, as they can interact in various national and international contexts.

Research Implications: It helps generate strategies for improving students' adaptation to the BIS modality in a practical way; theoretically, it provides the research community with certain bases for future studies.

Originality/Value: The work derives from a phenomenon detected in the UT subsystem in Mexico, particularly in the Technological University of Altamira, Tamaulipas. Because the implementation of such an educational model is still recent and the literature developed in this respect is scarce, the document presented here is a contribution to the scientific community, subject to its assessment.