bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perbandingan Terapi Peeling Kimiawi Dengan Glycolic Acid 35% dan Mandelic Acid 30% dalam Menurunkan Derajat Keparahan Akne Vulgaris
Authors: Mellaratna Wizar Putri , Millizia Anna , Nurfitri Erida Bela , Nurul Tasha Ghina 
Published: June 2023

Introduction: Acne vulgaris is a pilosebaceous unit disorder which is mostly seen in adolescents and adults with approximately 85% occurs at the age of 12-25 years. Methods: The purpose of this study is to know the comparison between chemical peeling therapy with 35% glycolic acids (GA) and 30% mandelic acids (MA) to reduce the severity of acne vulgaris. A total of 30 medical students suffering from mild to severe acne vulgaris were involved in this study. The patients were randomly divided into two groups, with one group receiving 35% GA and the other group receiving 30% MA peels at an interval of 4 weeks for two sessions. The Mann Whitney test is used to analysis the difference between chemical peeling therapy with 35% GA and 30% MA to reduce the severity of acne vulgaris. The p value < 0,05 is considered statistically significant. Results and discussion: majority of the patients are females (70,0%), age 14 years olds (50,0%), duration of acne vulgaris 7,8 and 10 years (16,7%). There is no significant difference between 35% GA and 30% MA in reducing the severity of acne vulgaris (p > 0,05). Chemical peels with MA has an antibacterial effect and is used to treat others skin disorders such as acne, photoaging, and pigmentation disorders. GA peels is proven to be effective in the treatment of inflammation and non-inflammation acne.
Conclusions: there is no difference between chemical peels with 35% GA and 30% MA in reducing the severity of acne vulgaris.
Keywords: acne vulgaris; chemicals peels, treatment, severity of acne
Biochemical characteristics and functional performance of cold-stored platelets: an in-vitro comparative study
Authors: Byomy Marwa , El Ekapy Magdy , Elmanzalawy Gamal , El Hakeem Amr , ElKharasawy Amr , Ibrahim Nehad R. , Ghani Amani , Abdellatif Raghda 
Published: June 2023

Background: Platelet refrigeration could eliminate bacterial contamination and improve the hemostatic function even better than already-used room-temperature storage. This study aimed to assess the effect of cold storage, with and without agitation, on the apheresis platelets' hemostatic, metabolic, and functional activity. Materials and methods: The study included 10 healthy volunteer donors to collect Apheresis PLT. They were submitted to careful clinical examination and standard laboratory workup. Collected samples were processed in accordance with American Association of Blood Banks (AABB) guidelines. Every aliquot collected from each volunteer was stored for up to 5 days at one of the following storage conditions: 1. In an FDA-approved-PLT incubator with agitation at room temperature (RT + AG as a group; GI), 2. In an FDA-approved-refrigerator at 4 oC with agitation (4 oC + AG as a group; GII), 3. In an FDA-approved- refrigerator at 4 oC without agitation (4 oC – AG as a group; GIII). The following PLT workup was done; PLT count and mean platelet volume (MPV), metabolic variables, PLT aggregation studies, PLT receptors expression, and PLT pro-inflammatory mediator’s release.Results:All samples had a significant PLT count decline compared to baseline data. No changes in MPV were observed in all groups on day 3 and day 5, meaning that single PLT size remained unchanged. In addition, GI showed a mark of significant increase in metabolic activity when compared to baseline PLTs in contrast to GII, and GIII, which were more metabolically stable and less active.Comparison between the studied groups regarding PLT aggregation revealed significantly higher PLT aggregation response to ADP and collagen in GII and GIII compared to GI on the 3rd and 5th days. Moreover, it was shown that GII and GIII samples had significantly higher CD62p expression when compared with GI on the 3rd and 5th days despite being less active and more stable. While it was found that TXB2 levels were significantly higher, nearly 3-fold, in GI as compared to GII and GIII.Conclusions: Apheresis platelets (AP) cold storage provides a clear advantage over standard conditions regarding biochemical balance and hemostatic performance, which could markedly improve AP's clinical and economic value in different scenarios. Keywords: Platelet aggregation, P-selectin, Thromboxane B2.
Evaluation of abdominal vascular structures by multidetector computed tomography in Crimean–Congo hemorrhagic fever patients
Authors: ÖZMEN Zafer 
Published: June 2023

Aim: This study aims to determine whether Crimean–Congo Hemorrhagic Fever (CCHF) has effects on abdominal vascular structures.
Material and Method: The study group included 35 patients diagnosed with CCHF. The control group included 35 patients with symptoms such as dyspepsia, pelvic pain, and abdominal pain who underwent multidetector computed tomography (MDCT) and whose MDCT examinations were reported as completely normal. This is a retrospective study and patients admitted to the hospital between May 2016 and April 2022 were included in the study. The patient group and control group were compared in terms of liver size, splenic size, and portal vein (PV), hepatic artery (HA), splenic vein (SV), splenic artery (SA), superior mesenteric vein (SMV) and superior mesenteric artery (SMA) diameters.
Results: The liver size, splenic size, and PV, HA, and SA diameters in the patient group were significantly higher than those in the control group (p0.05).
Conclusion: Our study shows that abdominal vascular structures are affected in CCHF patients.
The relationship between thoracic CT findings and C-reactive protein and ferritin levels in COVID-19 patients
Authors: SAĞLIK Semih , NAS Necip , ALTUNIŞIK Bilal 
Published: June 2023

Aim: In this study, we aimed to establish the relationship between thoracic computed tomography (CT) findings at initial presentation and CRP and ferritin levels in 232 patients diagnosed with COVID-19.
Material and Method: 232 patients who were diagnosed with COVID-19 and underwent a thoracic CT examination at our hospital between Apr 2020 and Aug 2021 were enrolled in this study. The study group was selected from among individuals aged 18-45 years without any chronic diseases and comorbidities. The patients' complaints, RT-PCR test results and blood biochemistry values from the medical records system, and CT imaging from the PACS system were reviewed retrospectively. Parenchymal lesions, ground-glass area, consolidation and combination of ground-glass area and consolidation observed on thoracic CT were considered typical findings. Blood samples were analyzed in the laboratory using standard methods. Routine blood tests were performed to measure serum C-reactive protein and ferritin levels.
Results: Out of the 232 patients infected with COVID-19, 118 were female and 114 were male. While the mean age of all patients was 34.9, the mean ages of men and women were 34.9 and 35.2, respectively. No significant differences were observed between the ages of patients with and without lung involvement (32.9, 37.9, p=0.903, respectively). CT scan showed typical parenchymal findings in 140 patients out of whom 65 were male and 75 were female. With regard to the morphologic features observed on CT, ground-glass density was the most common (74 patients), followed by a combination of ground-glass density and consolidation (34 patients) and finally consolidation (32 patients). In statistical analysis, no significant differences were found in CRP values between patients with and without lung involvement, whereas a significant difference was noted in ferritin values (p=0.196 and p
Evaluation of MULBSTA, SOFA, APACHE II scores and hematological parameters as predictors of mortality in COVID-19 pneumonia
Authors: GÜLSOY Kemal Yetiş , ANCIN Burcu , ORHAN Semiha 
Published: June 2023

Aim: COVID-19 (coronavirus disease 2019) pneumonia is a serious condition with high mortality and morbidity. Tools are needed for effective diagnosis and better prediction of prognosis in the course of this disease. This study aimed to compare the effectiveness of the MuLBSTA (Multilobular infiltration, hypo-Lymphocytosis, Bacterial coinfection, Smoking history, hyper-Tension and Age) score with blood parameters, SOFA (Sequential Organ Failure Assessment), and APACHE II (Acute Physiology and Chronic Health Evaluation II) scores, and to investigate its significance in predicting 28-day mortality in patients diagnosed with COVID-19 and followed up in the intensive care unit (ICU).
Material and Method: This study included 312 patients admitted to ICU for COVID-19 infection. SOFA, MuLBSTA and APACHE-II scores of patients were estimated at ICU admission. Demographic data and laboratory results of patients were retrospectively reviewed.
Results: Of the 312 patients included in the study, 58.7% (n=183) were male and 41.3% (n=129) were female. The AUC value was 0.863 for the SOFA score and 0.843 for the MuLBSTA score. The MuLBSTA score was positively correlated with the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), while it was negatively correlated with the lymphocyte-to-monocyte ratio (LMR). Patients were divided into two groups as high-risk and low-risk, considering a cut-off value of 12 for the MuLBTSA score. The survival time of patients with a high-risk MuLBTSA score was 12±0.78 days, while the survival time of patients with a low MuLBTSA score was 22.8±1.3 days.
Conclusion: The combined use of the MuLSBTA score, SOFA score, and NLR after ICU admission for COVID-19 pneumonia will be more effective in predicting mortality.
Outcomes of multiple pregnancies: results of a perinatology clinic in a tertiary health center
Authors: SEVER Barış , EKİN Atalay 
Published: June 2023

Aim: To evaluate maternal-fetal risks and pregnancy outcomes in multiple pregnancies.
Material and Method: The study included 226 patients with multiple pregnancies who applied to the Perinatology clinic of Izmir Tepecik Training and Research Hospital between January/2020 and December/2022. The data of the patients were recorded and evaluated retrospectively using the hospital database.
Results: Of 226 patients, 211 were twins, 14 were triplets and one was quadruplet. Pregnancy occurred after in vitro fertilization (IVF) in 116 patients and after donation in 1 patient. 55.7% of the patients were older than 35 years. While 137 pregnants (60.6%) were primiparous, 89 patients (39.3%) had a previous pregnancy. While 20 of the twin pregnancies delivered before the 25th gestational week, this number was found to be 7 for triplets. 202 (89.3%) of all multiple pregnant women were delivered by cesarean section. Hypertensive disorder was found in 28 of the twin pregnancies and in 4 of the triplet pregnancies. Gestational diabetes was observed in 41 twin and 3 triplet pregnancies. Small for gestational age (SGA) was observed in 121 twins, 13 triplets and 1 quadruplet pregnancy. Intrauterine growth retardation (IUGR) was observed in 76 twins and 6 triplets. The number of multiple pregnancies with a birth weight less than 2500 g was found to 187 (82.7%) in total. Major congenital anomalies of various organs (cardiac, central nervous system, etc.) were observed in 8 (3.5%) pregnant women.
Conclusion: Preterm birth, increased maternal morbidity and increased cesarean section frequency are some of the risks of multiple pregnancies. These risks can be reduced by knowing the potential risks of multiple pregnancies and by more careful follow-up starting from the early stages of pregnancy.
Comparison of risk scoring systems for the prediction of clinical outcomes in nonvariceal upper gastrointestinal bleeding: a prospective randomized study
Authors: DURAK Muhammed Bahaddin , BAŞPINAR Batuhan , GÜVEN İbrahim Ethem , YÜKSEL İlhami 
Published: June 2023

Aim: Non-variceal upper gastrointestinal bleeding (UGIB) is a typical gastrointestinal emergency. Detection of high-risk patients is crucial to organize medical care accordingly. This study aims to compare risk assessment scores for their ability to predict prognosis in nonvariceal-UGIB.
Material and Method: Adult patients with nonvariceal-UGIB applied to the emergency department were recruited prospectively. Clinical and Complete Rockall score (RS), Glascow-Blatchford score (GBS), AIMS65, and T-Score were compared for endpoints: (1) need for endoscopic treatment, (2) hospitalization, (3) rebleeding, and (4) 30-day mortality.
Results: A total of 469 patients were included. While 133 (28.0%) patients were discharged within 24 hours, 336 (72.0%) were hospitalized. The median length of hospital stay was 6.6 (0.0-8.0) days. Endoscopic treatment and transfusion were required in 109 (23.0%) and 255 (54.0%) patients, respectively. Rebleeding was observed in 36 (8.0%) patients. The 30-day mortality rate was 11.0 %. Complete Rockall score was superior among all risk scores regarding the prediction of the need for endoscopic treatment (AUC: 0.707, p
Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Ratis Renan C. , Dacoregio Maria I. , Simão-Silva Daiane P. , Mateus Rogério P. , Machado Luciana P.B. , Bonini Juliana S. , Silva Weber Claudio Francisco Nunes da 
Published: June 2023

Background: Alzheimer’s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor. Objective: To investigate the association between APOE4 and BCHE-K as a risk factor for AD. Methods: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele. Results: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558. Conclusion: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.
Levodopa Carbidopa Intestinal Gel in Advanced Parkinson’s Disease: DUOGLOBE Final 3-Year Results
Authors: Chaudhuri K. Ray , Kovács Norbert , Pontieri Francesco E. , Aldred Jason , Bourgeois Paul , Davis Thomas L. , Cubo Esther , Anca-Herschkovitsch Marieta , Iansek Robert , Siddiqui Mustafa S. , Simu Mihaela , Bergmann Lars , Ballina Mayra , Kukreja Pavnit , Ladhani Omar , Jia Jia , Standaert David G. 
Published: June 2023

Background: Levodopa-carbidopa intestinal gel (LCIG) improves motor and non-motor symptoms in patients with advanced Parkinson’s disease (aPD). Objective: To present the final 36-month efficacy and safety results from DUOGLOBE (DUOdopa/Duopa in Patients with Advanced Parkinson’s Disease – a GLobal OBservational Study Evaluating Long-Term Effectiveness; NCT02611713). Methods: DUOGLOBE was an international, prospective, long-term, real-world, observational study of patients with aPD initiating LCIG in routine clinical care. The primary endpoint was change in patient-reported “Off” time to Month 36. Safety was assessed by monitoring serious adverse events (SAEs). Results: Significant improvements in “Off” time were maintained over 3 years (mean [SD]: –3.3 hours [3.7]; p < 0.001). There were significant improvements to Month 36 in total scores of the Unified Dyskinesia Rating Scale (–5.9 [23.7]; p = 0.044), Non-Motor Symptoms Scale (–14.3 [40.5]; p = 0.002), Parkinson’s Disease Sleep Scale-2 (–5.8 [12.9]; p < 0.001), and Epworth Sleepiness Scale (–1.8 [6.0]; p = 0.008). Health-related quality of life and caregiver burden significantly improved through Months 24 and 30, respectively (Month 24, 8-item Parkinson’s Disease Questionnaire Summary Index, –6.0 [22.5]; p = 0.006; Month 30, Modified Caregiver Strain Index, –2.3 [7.6]; p = 0.026). Safety was consistent with the well-established LCIG profile (SAEs: 54.9% of patients; discontinuations: 54.4%; discontinuations due to an adverse event: 27.2%). Of 106 study discontinuations, 32 patients (30.2%) continued LCIG outside the study. Conclusion: DUOGLOBE demonstrates real-world, long-term, reductions in motor and non-motor symptoms in patients with aPD treated with LCIG.
Firefly-Aquila optimized Deep Q network for handoff management in context aware video streaming-based heterogeneous wireless networks
Authors: Waghmode Uttam , Kolekar Uttam 
Published: June 2023

Handoff management is the method in which the mobile node maintains its connection active when it shifts from location to other. The devastating success of mobile devices as well as wireless communications is emphasizing the requirement for the expansion of mobility-aware facilities. Moreover, the mobility of devices requires services adapting their behavior to abrupt context variations and being conscious of handoffs, which make an intermittent discontinuities and unpredictable delays. Thus, the heterogeneity of wireless network devices confuses the situation, since a dissimilar treatment of handoffs and context-awareness is essential for every solution. Hence, this paper introduced the Deep Q network-based Firefly Aquila Optimizer (DQN-FAO) for performing the handoff management. In order to establish the handoff management, the process of selecting network is very important. Here, the network is selected based on the devised FAO algorithm, which is the consolidation of Aquila Optimizer (AO) and Firefly algorithm (FA) that considers the metrics, such as Jitter, Handoff latency, and Received Signal Strength Indicator (RSSI) as fitness function. Moreover, the handover decision is taken by the DQN, where the hyper-parameters are tuned by the devised FAO algorithm. According to the hand over decision taken, the context aware video streaming is happened by adjusting the bit rate of the videos using network bandwidth. Besides, the devised scheme attained the superior performance based on the call drop, energy consumption, handover delay, throughput, handoff latency, and PSNR of 0.5122, 7.086 J, 10.54 ms, 13.17 Mbps, 93.80 ms and 46.89 dB.
Economically justified technological map of the cultivation of giant miscanthus (on the example of the Kaluga region)
Authors: Kuznetsova L. V. , Mazuro V. N. 
Published: June 2023

Relevance. Recently, the demand for paper of non-wood origin has increased. One of such sources is a perennial herbaceous plant Miscanthus giganteus from the bluegrass family.Methods. The technology of growing giant miscanthus was developed by scientists of the Kaluga Research Institute. The study was conducted in accordance with generally accepted methods and recommendations of leading technological and economic research institutes. Technological maps are calculated on the basis of the methods of M.A. Bunkov, V.M. Golovach, as well as E.V. Fastov, O.A. Kovalenko, N.G. Belova. The economic component of miscanthus production is calculated based on the methods of V.R. Boev and I.G. Ushachev.Results. During the calculations, it was found that the production of 1 ton of giant miscanthus straw according to the proposed production technology, with a planned yield of 15 tons/ha, will require 1,370 rubles. In the third year of using crop cultivation, the profitability of production, depending on the studied yield parameters (10, 15, 20 c/ha) is, respectively, 94,6%, 192,0%, 287,2%. The payback period of the project is five to eight years.
Dynamics of carbohydrate and lipid metabolism in cows with various clinical states during gestation
Authors: Vostroilova G. A. , Shaposhnikov I. T. , Brigadirov Yu. N. , Zhukov M. S. , Khokhlova N. A. , Chusova G. G. 
Published: June 2023

Relevance. It is known that among cows there is a wide spread of anemia and pathologies accompanied by chronic inflammation. Anemia, like chronic inflammation, leads to disorders that contribute to metabolic changes during pregnancy in cows and have their own characteristics.The aim of the work is to study the effect of pregnancy on carbohydrate and lipid metabolism of cows with anemia syndrome and chronic systemic inflammation.Methods. In the conditions of the livestock complex, studies were conducted on cows (n = 30) of a red-mottled breed with a pregnancy period of 150–160 days. Based on clinical and laboratory examination, the animals were divided into three groups: 1st (n = 15) — healthy, 2nd (n = 8) — with hypochromic microcytic anemia, 3rd (n = 7) — with low-intensity chronic systemic inflammation syndrome. Blood sampling was performed on the 150–160th, 210–220th and 260–265th days of pregnancy to determine the level of total lipids, cholesterol, triglycerides, glucose, lactic and pyruvic acid.Results. The levels of total lipids and glucose have a significant (р ˂ 0.05) inverse and the level of pyruvic acid has a significant direct correlation of noticeable and high strength according to the Chaddock scale with an increase in the duration of gestation in all studied groups. The presence of anemia or chronic systemic inflammation syndrome of low intensity in the transient period creates risks of metabolic failures, which are manifested by a decrease in the intensity of triglyceride deposition by 31.0–34.5% (р ˂ 0.05) and the appearance of a tendency to a negative energy balance.
Some aspects of antioxidant protection in the body of young cattle
Authors: Bogolyubova N. V. 
Published: June 2023

Relevance. Of scientific interest are studies to assess the pro- and antioxidant status of the body of productive animals with age, since they are interconnected with health, the state of the immune and reproductive systems.Methods. In order to study the indicators of antioxidant protection in the body of young cattle of different ages in the conditions of the PZ «Ladozhsky» (Krasnodar district), the following groups of animals were formed in the winter period of 2022: young animals at the age of 1 month (n = 15), 3–4 months (n = 19), young animals 6–7 months old (n = 14), heifers (n = 16). The following indicators were determined in the blood of the studied animals: the concentration of ceruloplasmin (CP), products reacting with thiobarbituric acid (TBA-AP), the total content of water-soluble antioxidants (TAWSA), the total antioxidant status (TAS), peroxidase activity, the ratio of TBA-AP/CP, metabolic processes and hematological indicators were calculated. Correlations between the determined indicators were calculated.Results. The results obtained indicate changes in the LPO and AOD indicators depending on age and physiological state. A significant increase in the concentration of TBA-AP in the blood of young animals 6–7 months old and heifers, compared with analogues of 1 and 3–4 months of age, indicates the accumulation of lipid peroxidation products with age. The decrease in the AOP level in the 6-month-old group of animals is also indicated by the minimum concentration of TAWSA and the trend towards a decrease in the total antioxidant status and peroxidase activity. Due to the high level of ceruloplasmin, the ratio of TBA to CP was at the level of other groups. The age of the animals had a significant effect (p ≤ 0.001) on the content of TBA-AP, ceruloplasmin, TAWSA, and the overall antioxidant status. SLE and TBA-AP are significant markers of the state of LPO and AOP in the body. The results obtained will allow monitoring the health status of animals and will help to provide timely preventive measures that increase the adaptive capabilities of young animals and the most complete realization of the genetic potential of productivity.