bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer effect of combinational therapy (sorafenib and anti-miR-222) on renal cell carcinoma cell lines: an invitro study
Authors: Komijani Erfan , Delashoub Masoud 
Published: March 2023

Abstract
Background: Sorafenib chemotherapy drug can fight renal cell carcinoma (RCC) cells, the most common kidney cancer, by preventing cell migration and viability and stimulating apoptosis. In recent years, studies on combination therapies in cancer have increased due to greater effectiveness and prevention of drug resistance. In this study, we aimed to investigate the apoptotic and anti-metastatic effect of sorafenib and anti-miR-222 on RCC cell lines
Methods: 786-O and Caki-1 were used as RCC cell lines. Gene expression of PD-L1, Bim, miR-34a, miR-122, miR-513, and miR-570 were evaluated using quantitative real-time polymerase chain reaction(qRT-PCR) before and after sorafenib treatment. Changes in cell viability, apoptosis, and cell migration respectively were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, flow cytometry, and scratch assay after treatment of 786-O and Caki-1 cell lines with sorafenib and anti-miR-222.
Results: Sorafenib led to increased expression of PD-L1, Bim, miR-34a, miR-122, miR-513, and miR-570genes in 786-O and Caki-1 cell lines. MTT assay results showed that cotreatment of 786-O and Caki-1 cell lines with sorafenib and anti-miR-222 solely and together decrease cell viability but combination therapies results were more significant. Also, the data of the apoptosis test showed an increased apoptosis rate in both 786-O and Caki-1 cell lines after treatment with sorafenib and anti-miR-222 solely and together but combination therapies results were more remarkable. The scratch test results also showed a decrease in cell migration in both cell lines in the treatment with sorafenib and anti-miR-222 solely and together after 24 and 48 hours but combination therapies results were more considerable.
Conclusion: Therefore, the present study shows a significant enhancement of the increase in apoptosis, as well as a significant decrease in cell migration and viability, after the use of sorafenib and anti-miR-222 at the same time. It seems that these results can contribute to the development of therapeutic strategies against RCC.
Impact of the approach on conversion to open surgery during minimally invasive restorative total mesorectal excision for rectal cancer
Authors: Larach José Tomás , Kong Joseph CH , Flynn Julie , Wright Timothy , Mohan Helen , Waters Peadar , McCormick Jacob , Warrier Satish , Heriot Alexander 
Published: March 2023

Abstract
Background: The aim of this study is to explore the impact of the approach on conversion in patients undergoing minimally invasive restorative total mesorectal excisionwithin a single unit.
Methods:A retrospective cohort study was conducted at a public quaternary and a private tertiary centre. Patients with rectal cancer undergoing minimally invasive restorative total mesorectal excision between January 2006 and June 2020 were included. Subjects were grouped according to the presence of conversion. Baseline variables and short-term outcomes were compared. Regression analyses were performed to examine the impact of the approach on conversion.
Results: During the study period, some 318 patients had a restorative proctectomy. Of these, 240 met the inclusion criteria. Robotic and laparoscopic approaches were undertaken in 147 (61.3%) and 93 (38.8%) cases, respectively. A transanal approach was utilised in 62 (25.8%) cases (58.1% in combination with a robotic transabdominal approach). Conversion to open surgery occurred in 30 cases (12.5%). Conversion was associated with an increased overall complication rate (P=0.003), surgical complications (P=0.009), superficial surgical site infections (P=0.02) and an increased length of hospital stay (P=0.006). Robotic and transanal approaches were both associated with decreased conversion rates. The multiple logistic regression analysis, however, showed that only a transanal approach was associated with a lower risk of conversion (OR 0.147,0.023–0.532,P=0.01), whilst obesity was an independent risk factor for conversion (OR 4.388,1.852–10.56,P<0.00).
Conclusions: A transanal component is associated with a reduced conversion rate in minimally invasive restorative total mesorectal excision, regardless of the transabdominal approach utilised. Larger studies will be required to confirm these findings and define which subgroup of patients could benefit from transanal component when a robotic approach is undertaken.
Dermatofibrosarcoma protuberans：clinical and pathological analysis of Asian samples from one center experience.
Authors: Peng Qili , Lu Yi , Huang Renhua , Tong Pengpeng , Hu Xiaohong , Fu Mingang , Pi Qingmeng , Huang Yixiong , Chen Rui 
Published: March 2023

Abstract
Background：Dermatofibrosarcoma protuberans（DFSP）is one of rare and low-grade fibrohistiocytic tumor with malignant potential biological behavior. With the pathological character of the finger-like lesion invading soft tissues, DFSP is considered to be high rate of local recurrence.
Method: In this study, we reported a retrospective study of 17 DFSP patients with surgery medical history and long-time follow-up period. All the cases were reviewed by research group with the clinical features, operation outcomes and pathological parameters.
Results: 17 Asian patients were included in this study (the mean age is 41.82 years old with 9 females and 8 males). Location of DFSP are the belly (7/17 41.2%), the chest（2/17 11.8%）,the shoulder(5/17 29.4%), the face(1/17 5.9%), the perineum（1/17 5.9%） and the right leg（1/17 5.9%）. 6 cases were closed by plastic surgical suture（35.29%），3 cases by full thickness skin graft（17.65%）and 8 cases by pedicled flap（47.06%）. CD34 and Vimentin positively is 100%, 90% respectively. Desmin and S-100 negatively were 100%. The median value of Ki-67 is 12%.
Conclusion: The challenge of DFSP is clinical local control after operation. The first choice of DFSP treatment is surgery with the aim of clear margin and properly reconstruction. For the clinical practice, Enhancing the clinical recognition of DFSP in the initial medical visit is important for proper management and operation opportunity.
Spatial distribution for assessing exposure of particulate matter (PM 10 ) in a densely populated coalfield using land use regression model
Authors: Srivast Amartanshu , Elumalai Suresh Pandian 
Published: March 2023

Abstract
It is prudent to explore the spatial distribution of air pollution especially in mining affected land use as the coal mining area are expanding with increasing energy demand. In this study, the LUR model is developed to predict the spatial distribution of respirable particulates (PM10) concentration in a cluster of coal mines situated in a thickly populated region. Taking the agglomeration of Kusunda-Bastacolla administrative areas in JCF of India as a case study, the modified LUR model was tested. Results revealed that the eastern zone of the study area had higher concentration levels due to high population density and opencast coal mines as the major cause of elevated PM10 concentration levels. The PM10 concentration levels also followed a seasonal trend with being more elevated in winter followed by post-monsoon and summer. This study's potential predictor variables were area proportions of land use, traffic road length, population density, elevation, and land surface temperature (LST). The model validation showed that the modified LUR model with LST as predictor variable performed moderately with obvious average cross-validation based R2 (0.47) and lower RMSE (30.6 µg/m3). It can be concluded that the modified LUR model can provide a feasible tool for mapping PM10 concentration and exposure on population while planning future coal mining expansion.
Click-Through Rate Prediction Based on User Behaviors and Feature Importance
Authors: Wang Yingqi , Ji Huiqin , Yu Junyang , He Xin , Li Zheng , Liu TianXu 
Published: March 2023

Abstract
Click-through rate prediction is one of the hot topics in the field ofrecommendation and advertising systems. The existing CTR predictionmodels mainly include feature interaction and behavior sequence. Forexample, PNN, DCN and other models use deep learning methods toextract feature interaction information, while DIN and DIEN captureuser interest through user’s historical behavior, and then use attentionmechanism to model the relationship between target items and behavior sequences. However, the existing CTR prediction techniques eitherignore both aspects or only consider one of them, which limit the prediction performance. In order to solve the above problems, we proposea click-through prediction model CUBFI that combines user behaviorand feature importance in this paper. Firstly, In order to extract interests, Global-local Gate and Post-LN Informer module are proposed atthe interest extraction layer. In addition, we introduce auxiliary losses tosupervise the extraction of user interest features. Secondly, In the interestupdate layer, we introduce A-GRU to enhance the relationship betweeninterest expression and target items. Finally, for non-temporal features,this paper proposes a multi-cross layer to increase the nonlinear abilityof the model. Experiments show that our model can effectively improve the click-through rate prediction accuracy of advertisements. The codes will be available at https://github.com/jihuiqin2/sequence ctr.
Beyond Image Defined Risk Factors (Idrfs): A Delphi Survey Highlighting Definition of the Surgical Complexity Index (Sci) in Neuroblastoma
Authors: Avanzini Stefano , Dall’Igna Patrizia , Bjornland Kristin , Braungart Sarah , Cross Kate , Flores Paula , Gabra Hany , Gomez-Chacon Javier , Irtan Sabine , Lobos Pablo , Loh Amos , Matthyssens Lucas , Metzelder Martin , Parodi Stefano , Pio Luca , de Ven Cornelius Van , Fuchs Joerg , Losty Paul , Sarnacki Sabine 
Published: March 2023

Abstract
PURPOSE
Preoperative evaluation of Image Defined Risk Factors (IDRFs) in neuroblastoma (NB) is crucial for determining suitability for upfront resection or tumor biopsy. IDRFs do not all carry the same weighting in predicting tumor complexity and surgical risk. In this study we aimed to assess and categorize a surgical complexity (Surgical Complexity Index, SCI) in NB resection.
METHODS
A panel of 15 surgeons was involved in an electronic Delphi consensus survey to identify and score a set of shared items predictive and/or indicative of surgical complexity, including the number of preoperative IDRFs. A shared agreement included the achievement of at least 75% consensus focused on a single or two close risk categories.
RESULTS
After 3 Delphi rounds, agreement was established on 25/27 items (92.6%). A severity score was established for each item ranging from 0 to 3 with an overall SCI range varying from a minimum score of zero to a maximum score of 29 points for any given patient.
CONCLUSIONS
A consensus on a SCI to stratify the risks related to neuroblastoma tumor resection was established by the panel experts. This index will now be deployed to critically assign a better severity score to IDRFs involved in NB surgery.
Dominance of epigenetic modulators shared among the inflammatory disorders with prominent thrombotic phenotypic feature
Authors: CHANCHAL SHANKAR , Sharma Swati , Mohd Syed , Mishra Aastha , Ashraf Mohammad Zahid 
Published: March 2023

Abstract
Objective
Exploration of the underlying molecular mechanisms between inflammation and coagulation pathways using publicly available transcriptome datasets of inflammatory disorders with pro-thrombotic phenotypic features.
Methods
Publicly available mRNA and miRNA expression datasets of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD) along with venous thrombosis (VT) were retrieved from GEO database. Pre-processing of the gene expression datasets was followed by functional analysis, Protein-protein interaction network, hub genes analysis, and their interactions with differentially expressed miRNAs (DEmiRs).
Results
Functional analysis of the differentially expressed genes (DEGs) showed enrichment of epigenetic pathways. PPI analysis showed epigenetic genes Histone Deacetylase 1, Histone Deacetylase 2, Fos Proto-Oncogene, Protein Kinase, DNA-Activated, Catalytic Subunit, RB Binding Protein 4, and Chromatin Remodeling Factor among the top hub genes. Meta-analysis of miRNA datasets showed 30 shared DEmiRs. 9 common miRNAs hsa-mir-198, hsa-mir-298, hsa-mir-520b, hsa-mir-422a, hsa-mir-484, hsa-mir-449, hsa-mir-429, hsa-mir-326, and hsa-mir-375 regulating DEGs involved in epigenetic modulation were identified between the DEmiRs and miRNA interacting partners of top hub genes.
Conclusion
An overrepresentation of chromatin modulators among the top enriched pathways and histone modifying enzymes among the top identified hub genes indicates a promising epigenetic aspect for exploration in the context of immunothrombosis.
Improving access to early intervention for autism – findings from a proof-of-principle cascaded task-sharing naturalistic developmental behavioural intervention in South Africa
Authors: Rieder Amber D , Viljoen Marisa , Seris Noleen , Shabalala Nokuthula , Ndlovu Minkateko , Turner Elizabeth L , Simmons Ryan , Vries Petrus J , Franz Lauren 
Published: March 2023

Abstract
Background
Despite the high number of children living with neurodevelopmental disabilities in sub–Saharan Africa, access to early intervention is almost non-existent. It is therefore important to develop feasible, scalable early autism intervention that can be integrated into systems of care. While Naturalistic Developmental Behavioural Intervention (NDBI) has emerged as an evidence-based intervention approach, implementation gaps exist globally, and task-sharing approaches may address access gaps. In this South African proof-of-principle pilot study, we set out to answer two questions about a 12-session cascaded task-sharing NDBI – whether the approach could be delivered with fidelity, and whether we could identify signals of change in child and caregiver outcomes.
Methods
We utilized a single-arm pre-post design. Fidelity (non-specialists, caregivers), caregiver outcomes (stress, sense of competence), and child outcomes (developmental, adaptive) were measured at baseline (T1) and follow-up (T2). Ten caregiver-child dyads and four non-specialists participated. Pre-to-post summary statistics were presented alongside individual trajectories. Non-parametric Wilcoxon signed rank test for paired samples was used to compare group medians between T1 and T2.
Results
Caregiver implementation fidelity increased in 10/10 participants. Non-specialists demonstrated a significant increase in coaching fidelity (increases in 7/10 dyads). Significant gains were seen on two Griffiths-III subscales (Language/Communication – 9/10 improved, Foundations of Learning – 10/10 improved) and on the General Developmental Quotient (9/10 improved). Significant gains were also seen on two Vineland Adaptive Behaviour Scales (Third Edition) subscales (Communication – 9/10 improved, Socialization – 6/10 improved) and in the Adaptive Behaviour Standard Score (9/10 improved). Caregiver sense of competence improved in 7/10 caregivers and caregiver stress in 6/10 caregivers.
Conclusions
This proof-of-principle pilot study of the first cascaded task-sharing NDBI in Sub-Saharan Africa provided fidelity and intervention outcome data which supported the potential of such approaches in low-resource contexts. Larger studies are needed to expand on the evidence-base and answer questions on intervention effectiveness and implementation outcomes.
Exploring the association between network centralities and passenger flows in metro systems
Authors: Kopsidas Athanasios , Douvaras Aristeides , Kepaptsoglou Konstantinos 
Published: March 2023

AbstractNetwork science offers valuable tools for planning and managing public transportation systems, with measures such as network centralities proposed as complementary predictors of ridership. This paper explores the relationship between different cases of passenger flows at metro stations and network centralities of both metro and alternative public transport (substitute) networks; such an association can be useful for managing metro system operations when disruptions occur. For that purpose, linear regression and non-parametric machine learning models are developed and compared. The Athens metro system is used as testbed for developing the proposed methodology. The findings of this study can be used for deriving medium-term ridership estimates in cases of metro disruptions, as the proposed methodology can support contingency plans for both platform and rail track disruptions.
Prevalence of Palliative Radiotherapy Abstracts Presented at Annual Scientific Meetings of the Canadian Association of Radiation Oncology: 2003-2021
Authors: Sidhoo Saveen , Ghosh Sunita , Barnes Elizabeth A , Cuartero Julie , Fairchild Alysa 
Published: March 2023

Abstract
Purpose.Approximately half of all radiotherapy (RT) is delivered with palliative intent. Clinical research in palliative RT aims to manage symptoms, improve quality of life (QoL), evaluate supportive care, and determine optimal dose-fractionation schedules. Our aim was to describe the prevalence of palliative research at the Canadian Association of Radiation Oncology (CARO) Annual Scientific Meeting (ASM) over time.
Methods. Published abstracts (2003-2021) were independently reviewed by two authors who categorized each as: curative-intent; palliative-intent; pertaining to both populations; or neither. Abstracts were considered palliative if they described incurable malignancy and interventions primarily for symptom control or QoL. Type of study, primary, site treated, and symptoms palliated were recorded. Descriptive and summary statistics were calculated including one-way ANOVA test for trend.
Results. 339/4566 abstracts (7.4%, range 2.4-13.9% per year) were classified as palliative. 7.7% (26/339) described phase I-III trials. The main primary site was lung (39/339) and the most common metastatic site was bone (34.2%). QoL, symptom and toxicity outcomes were reported in 31.6% (107/339), 37.8% (128/339) and 17.7% (60/339), respectively. The most common symptom investigated was pain (38/339). The proportion of abstracts classified as curative, palliative or reporting toxicity endpoints demonstrated significant change over time (all p<0.0001).
Conclusion. While proportion of palliative themed abstracts has increased with time, there remains a significant gap before equivalence with the prevalence of palliative RT in clinical practice is achieved.
Female philopatry and unsuccessful male dispersal of a top predator in a human-modified landscape revealed by relatedness analysis
Authors: de Oliveira Marina E. , Saranholi Bruno H. , Miotto Renata A. , Silos Andiara S. M. C. , Dirzo Rodolfo , Galetti Pedro M. 
Published: March 2023

Abstract

Habitat loss and fragmentation threaten population persistence because they affect the individuals’ ability to disperse between remaining habitat patches and reduce areas of refuge for populations. In cougars (Puma concolor), males are predominantly dispersers while females tend to be philopatric. To examine cougar philopatry and dispersal ability in a human-dominated landscape in Brazil, we performed relatedness and spatial autocorrelation analyses based on genetic samples of cougars inhabiting forest fragments within a human-modified matrix, a continuous forest, and a pool of road-killed individuals. Our expectation was that females would be more related to each other and show a more positive autocorrelation than males in areas with less human disturbance because male dispersal would not be constrained. We found similarly high relatedness and a positive spatial autocorrelation at the shortest spatial scale (0-100 km) for both males and females from the forest fragments within a human-modified matrix. We also detected higher male:female ratio from roadkills, likely due to males’ higher tendency to disperse. Our results confirm female philopatry in the forest fragments. However, high relatedness and positive autocorrelation also observed for males in these fragments suggest male kin clustering, which could be a result of unsuccessful dispersal. Cougar unsuccessful dispersal has already been reported in North America in response to human-altered landscapes, but here we present the first evidence of this process in a South American cougar population. Further research is warranted to assess the specific causes of male unsuccessful dispersal and how it can affect species persistence in human-dominated landscapes.
Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey:
Authors: Alzyoud Raed , El-Kholy Nermeen , Arab Yousra , Choueiter Nadine , Harahsheh Ashraf S. , Aselan Adnan Salem , Kotby Alyaa , Bouaziz Asma , Salih Aso F. , Abushhaiwia Awatif , Alahmadi Fahad , Agha Hala M. , Elmarsafawy Hala M. , Alrabte Hanifa , Al-Saloos Hesham , Boudiaf Houda , Hijazi Issa , Bouayed Kenza , Senaidi Khalfan Salim Al , Boughammoura Lamia , Jalal Maryam , Ladj Mohamed S. , Abu-Shukair Mohammed E. , Ganzoury Mona M. El , Hammadouche Nacera , Elsamman Nora , Mouawad Pierre , Boukari Rachida , Benalikhoudja Nassiba , Jd Salima , Al-Saoud Sima Y. Abu , Touri Soued Nabila , Kammoun Thouraya , Fitouri Zohra , Dahdah Nagib 
Published: March 2023

Abstract
Kawasaki Disease (KD) is still the most common acquired heart disease in children below the age of five years; it has been well described in the developed world; however, data from the Arab world are limited to case reports or single-center case series. In an effort of optimizing KD research in the Arab world, a group of physicians and researchers established the KD Arab Initiative (Kawarabi) in 2021, and published the first survey, which showed disparities in the availability of intravenous immunoglobulin (IVIG); this had prompted Kawarabi to assess the access to care and therapy of KD patients in Arab countries. A 32 structured questions survey was conducted in thirteen Arab countries and addressed KD patients’ access to healthcare in urban and rural settings. The survey results showed that access to care was uniform across large, mid-size cities and rural areas in 7/13 (54%) countries, while in 6/13 (46%) countries, it was in favor of large and mid-size cities over rural areas. The quality of medical services received by children with KD in large cities was rated as excellent in 6/13 or good in 7/13 countries compared to fair in 4/13 or poor in 4/13 countries in rural areas. Availability of IVIG was limited (23%) in mid-size cities and almost impossible (23%) in rural areas. The KD patients in mid-size cities and rural areas have limited access to standard healthcare in the Arab world. This survey laid the foundation for future Kawarabi endeavors to improve the care of children with KD.