bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materials for Cell Surface Engineering
Authors: Adebowale Kolade , Liao Rick , Suja Vineeth Chandran , Kapate Neha , Lu Andrew , Gao Yongsheng , Mitragotri Samir 
Published: February 2023

AbstractCell therapies are emerging as a promising new therapeutic modality in medicine, generating effective treatments for previously incurable diseases. Clinical success of cell therapies has energized the field of cellular engineering, spurring further exploration of novel approaches to improve their therapeutic performance. Engineering of cell surfaces using natural and synthetic materials has emerged as a valuable tool in this endeavor. This review summarizes recent advances in the development of technologies for decorating cell surfaces with various materials including nanoparticles, microparticles, and polymeric coatings, focusing on the ways in which surface decorations enhance carrier cells and therapeutic effects. Key benefits of surface‐modified cells include protecting the carrier cell, reducing particle clearance, enhancing cell trafficking, masking cell‐surface antigens, modulating inflammatory phenotype of carrier cells, and delivering therapeutic agents to target tissues. While most of these technologies are still in the proof‐of‐concept stage, the promising therapeutic efficacy of these constructs from in vitro and in vivo preclinical studies has laid a strong foundation for eventual clinical translation. Cell surface engineering with materials can imbue a diverse range of advantages for cell therapy, creating opportunities for innovative functionalities, for improved therapeutic efficacy, and transforming the fundamental and translational landscape of cell therapies.
Liquid Crystal Elastomer Based Dexterous Artificial Motor Unit
Authors: Wang Yang , He Qiguang , Wang Zhijian , Zhang Shengjia , Li Chenghai , Wang Zijun , Park Yong‐Lae , Cai Shengqiang 
Published: February 2023

AbstractDespite the great advancement in designing diverse soft robots, they are not yet as dexterous as animals in many aspects. One challenge is that they still lack the compact design of an artificial motor unit with a great comprehensive performance that can be conveniently fabricated, although many recently developed artificial muscles have shown excellent properties in one or two aspects. Herein, an artificial motor unit is developed based on gold‐coated ultrathin liquid crystal elastomer (LCE) film. Subject to a voltage, Joule heating generated by the gold film increases the temperature of the LCE film underneath and causes it to contract. Due to the small thermal inertial and electrically controlling method of the ultrathin LCE structure, its cyclic actuation speed is fast and controllable. It is shown that under electrical stimulation, the actuation strain of the LCE‐based motor unit reaches 45%, the strain rate reaches 750%/s, and the output power density is as high as 1360 W kg‐1. It is further demonstrated that the LCE‐based motor unit behaves like an actuator, a brake, or a nonlinear spring on demand, analogous to most animal muscles. Finally, as a proof‐of‐concept, multiple highly dexterous artificial neuromuscular systems are demonstrated using the LCE‐based motor unit.
Enhancement of Charge Separation and NIR Light Harvesting through Construction of 2D–2D Bi4O5I2/BiOBr:Yb3+, Er3+ Z‐Scheme Heterojunctions for Improved Full‐Spectrum Photocatalytic Performance
Authors: Li Yongjin , Ma Junhao , Xu Liang , Liu Tong , Xiao Taizhong , Chen Daomei , Song Zhiguo , Qiu Jianbei , Zhang Yueli 
Published: February 2023

AbstractDeveloping full‐spectrum photocatalysts with simultaneous broadband light absorption, excellent charge separation, and high redox capabilities is becoming increasingly significant. Herein, inspired by the similarities in crystalline structures and compositions, a unique 2D–2D Bi4O5I2/BiOBr:Yb3+,Er3+ (BI‐BYE) Z‐scheme heterojunction with upconversion (UC) functionality is successfully designed and fabricated. The co‐doped Yb3+ and Er3+ harvest near‐infrared (NIR) light and then convert it into visible light via the UC function, expanding the optical response range of the photocatalytic system. The intimate 2D–2D interface contact provides more charge migration channels and enhances the Förster resonant energy transfer of BI‐BYE, leading to significantly improved NIR light utilization efficiency. Density functional theory (DFT) calculations and experimental results confirm that the Z‐scheme heterojunction is formed and that this heterojunction endows the BI‐BYE heterostructure with high charge separation and strong redox capability. Benefit from these synergies, the optimized 75BI‐25BYE heterostructure exhibits the highest photocatalytic performance for Bisphenol A (BPA) degradation under full‐spectrum and NIR light irradiation, outperforming BYE by 6.0 and 5.3 times, respectively. This work paves an effective approach for designing highly efficient full‐spectrum responsive Z‐scheme heterojunction photocatalysts with UC function.
Ligand‐Triggered Self‐Assembly of Flexible Carbon Dot Nanoribbons for Optoelectronic Memristor Devices and Neuromorphic Computing
Authors: Ai Lin , Pei Yifei , Song Ziqi , Yong Xue , Song Haoqiang , Liu Gongjie , Nie Mingjun , Waterhouse Geoffrey I. N. , Yan Xiaobing , Lu Siyu 
Published: February 2023

AbstractCarbon dots (CDs) are widely utilized in sensing, energy storage, and catalysis due to their excellent optical, electrical and semiconducting properties. However, attempts to optimize their optoelectronic performance through high‐order manipulation have met with little success to date. In this study, through efficient packing of individual CDs in two‐dimensions, the synthesis of flexible CDs ribbons is demonstrated technically. Electron microscopies and molecular dynamics simulations, show the assembly of CDs into ribbons results from the tripartite balance of π–π attractions, hydrogen bonding, and halogen bonding forces provided by the superficial ligands. The obtained ribbons are flexible and show excellent stability against UV irradiation and heating. CDs ribbons offer outstanding performance as active layer material in transparent flexible memristors, with the developed devices providing excellent data storage, retention capabilities, and fast optoelectronic responses. A memristor device with a thickness of 8 µm shows good data retention capability even after 104 cycles of bending. Furthermore, the device functions effectively as a neuromorphic computing system with integrated storage and computation capabilities, with the response speed of the device being less than 5.5 ns. These properties create an optoelectronic memristor with rapid Chinese character learning capability. This work lays the foundation for wearable artificial intelligence.
Blue‐Emitting 2‐Fluoroaryl‐1,2,3‐Triazole Fluorophores: Synthesis, Theoretical Calculations, and Optical Properties
Authors: Lavrinchenko Igor A. , Moseev Timofey D. , Seleznev Yuri A. , Varaksin Mikhail V. , Tsmokaluk Anton N. , Charushin Valery N. , Chupakhin Oleg N. 
Published: February 2023

AbstractA convenient multistep synthetic methodology to afford prospective push‐pull fluorophores based on the N(2)‐fluoroaryl‐1,2,3‐triazole scaffold as valuable functional blocks in the design of blue‐emitting organic materials is reported. The strategy includes five synthetic steps with yields of 60–99% at each stage. The obtained photoactive molecules, 2‐fluoroaryl‐5‐aryl‐4‐methyl‐1,2,3‐triazoles, were found to possess a blue‐violet emission in the range of λ=330–440 nm and the absolute quantum yield of >99% in solvents of different polarities. The electron transfer mechanistic features in the excited states for the developed N(2)‐fluoroaryl‐1,2,3‐triazoles compared to the 1,2,3‐triazoles‐1‐oxide analogues were also studied by using DFT and CIS calculations.
Reactivities of α‐Oxo BMIDA Gold Carbenes Generated by Gold‐Catalyzed Oxidation of BMIDA‐Terminated Alkynes
Authors: Zheng Yang , Jiang Jingxing , Li Yue , Wei Yongliang , Zhang Junqi , Hu Jundie , Ke Zhuofeng , Xu Xinfang , Zhang Liming 
Published: February 2023

AbstractAn oxidative strategy is reported to access α‐oxo BMIDA gold carbenes directly from BMIDA‐terminated alkynes. Besides offering expedient access to seldom studied boryl metal carbenes, these BMIDA gold carbene species undergo facile insertions into methyl, methylene, methine, and benzylic C−H bonds in the absence of the Thorpe–Ingold effect. They also undergo efficient OH insertion, cyclopropanation, and F−C alkylations. This chemistry provides rapid access to structurally diverse α‐BMIDA ketones, which are scarcely documented. In combination with DFT studies, the role of BMIDA is established to be an electron‐donating group that attenuates the high electrophilicity of the gold carbene center.
Direct N−H Activation to Generate Nitrogen Radical for Arylamine Synthesis via Quantum Dots Photocatalysis
Authors: Gan Qi‐Chao , Qiao Jia , Zhou Chao , Ci Rui‐Nan , Guo Jia‐Dong , Chen Bin , Tung Chen‐Ho , Wu Li‐Zhu 
Published: February 2023

AbstractRepresented herein is the first example of N‐radical generation direct from N−H bond activation under mild and redox‐neutral conditions. The in situ generated N‐radical intercepts a reduced heteroarylnitrile/aryl halide for C−N bond formation under visible‐light irradiation of quantum dots (QDs). A series of aryl and alkylamines with heteroarylnitriles/aryl halides exhibit high efficiency, site‐selectivity and good functional‐group tolerance. Moreover, consecutive C−C and C−N bond formation using benzylamines as substrates is also achieved, producing N‐aryl‐1,2‐diamines with H2 evolution. The redox‐neutral conditions, broad substrate scope, and efficiency of N‐radical formation are advantageous for organic synthesis.
When It's Heavier: Interfacial and Solvation Chemistry of Isotopes in Aqueous Electrolytes for Zn‐ion Batteries
Authors: Gao Xuan , Dai Yuhang , Zhang Chengyi , Zhang Yixuan , Zong Wei , Zhang Wei , Chen Ruwei , Zhu Jiexin , Hu Xueying , Wang Mingyue , Chen Ruizhe , Du Zijuan , Guo Fei , Dong Haobo , Liu Yiyang , He Hongzhen , Zhao Siyu , Zhao Fangjia , Li Jianwei , Parkin Ivan P. , Carmalt Claire J. , He Guanjie 
Published: February 2023

AbstractThe electrochemical effect of isotope (EEI) of water is introduced in the Zn‐ion batteries (ZIBs) electrolyte to deal with the challenge of severe side reactions and massive gas production. Due to the low diffusion and strong coordination of ions in D2O, the possibility of side reactions is decreased, resulting in a broader electrochemically stable potential window, less pH change, and less zinc hydroxide sulfate (ZHS) generation during cycling. Moreover, we demonstrate that D2O eliminates the different ZHS phases generated by the change of bound water during cycling because of the consistently low local ion and molecule concentration, resulting in a stable interface between the electrode and electrolyte. The full cells with D2O‐based electrolyte demonstrated more stable cycling performance which displayed ∼100 % reversible efficiencies after 1,000 cycles with a wide voltage window of 0.8–2.0 V and 3,000 cycles with a normal voltage window of 0.8–1.9 V at a current density of 2 A g−1.
Asymmetric Synthesis of Chiral Sulfimides through the O‐Alkylation of Enantioenriched Sulfinamides and Addition of Carbon Nucleophiles
Authors: Tsuzuki Saori , Kano Taichi 
Published: February 2023

AbstractChiral sulfimides, the aza‐analogues of sulfoxides, are valuable compounds in organic synthesis and medicinal chemistry. Herein, we report an efficient method for preparing chiral sulfimides from easily available enantioenriched sulfinamides. The key step of this method is a stereospecific oxygen‐selective alkylation of enantioenriched sulfinamides, which is accomplished by using isopropyl iodide, K2CO3, and DMPU. The resulting chiral sulfinimidate esters are transformed to chiral sulfimides by the nucleophilic addition of the Grignard reagents under simple conditions. This transformation enables access to the enantioenriched diaryl or dialkyl sulfimides bearing two similar carbon substituents, which are difficult to synthesize by previous methods.
Immunogenen Zelltod induzierende Metallkomplexe für die Krebstherapie
Authors: Zhang Lingpu , Montesdeoca Nicolás , Karges Johannes , Xiao Haihua 
Published: February 2023

AbstractKrebs ist eine der tödlichsten Krankheiten weltweit. Jüngste Statistiken haben gezeigt, dass Metastasen und Tumorrückfälle die Hauptursachen für krebsbedingte Todesfälle sind. Während herkömmliche Behandlungen in der Lage sind den Primärtumor effizient zu entfernen, sind sekundäre Tumore nach wie vor nur schwer zugänglich. Aus diesem Grund besteht ein dringender Bedarf an neuen Behandlungsmethoden. Zu den vielversprechendsten Ansätzen gehören immunogenen Zelltod auslösende Wirkstoffe, die in der Lage sind, sowohl den lokalen Zelltod der Krebszellen zu bewirken als auch eine Immunreaktion im gesamten Organismus hervorzurufen. Vorläufige Studien haben gezeigt, dass immunogenen Zelltod auslösende Verbindungen in der Lage sein könnten, metastasierende und rückfällige Tumore zu bekämpfen. In diesem Artikel wird die Anwendung von Metallkomplexen als immunogenen Zelltod auslösende Verbindungen systematisch untersucht.
Alkyne Insertion Enabled Vinyl to Acyl 1,5‐Palladium Migration: Rapid Access to Substituted 5‐Membered‐Dihydrobenzofurans and Indolines
Authors: Ding Mingruo , Ou Pengcheng , Li Xuening , Yu Yinghua , Niu Mengmeng , Yang Yongjian , Huang Yewei , Wang Zhi‐Xiang , Huang Xueliang 
Published: February 2023

Abstract“Through space” palladium/hydrogen shift is an efficient strategy to achieve selective functionalization of a specific remote C−H bond. Compared with relatively extensive exploited 1,4‐palladium migration process, the relevant 1,5‐Pd/H shift was far less investigated. We herein report a novel 1,5‐Pd/H shift pattern between a vinyl and an acyl group. Through the pattern, rapid access to 5‐membered‐dihydrobenzofuran and indoline derivatives has been achieved. Further studies have unveiled an unprecedented trifunctionalization (vinylation, alkynylation and amination) of a phenyl ring through 1,5‐palladium migration relayed decarbonylative Catellani type reaction. A series of mechanistic investigations and DFT calculations have provided insights into the reaction pathway. Notably, it was unveiled that the 1,5‐palladium migration in our case prefers a stepwise mechanism involving a PdIVintermediate.
Electrically Switchable Persistent Spin Texture in a Two‐Dimensional Hybrid Perovskite Ferroelectric
Authors: Guo Wuqian , Xu Haojie , Ma Yu , Liu Yi , Gao Heng , Hu Tao , Ren Wei , Luo Junhua , Sun Zhihua 
Published: February 2023

AbstractAs a momentum‐independent spin configuration, persistent spin texture (PST) could avoid spin relaxation and play an advantageous role in spin lifetime. Nevertheless, manipulation of PST is a challenge due to the limited materials and ambiguous structure–property relationships. Herein, we present electrically switchable PST in a new 2D perovskite ferroelectric, (PA)2CsPb2Br7 (where PA is n‐pentylammonium), which has a high Curie temperature of 349 K, evident spontaneous polarization (3.2 μC cm−2) and a low coercive electric field of 5.3 kV cm−1. The combination of symmetry‐breaking in ferroelectrics and effective spin‐orbit field facilitates intrinsic PST in the bulk and monolayer structure models. Strikingly, the directions of spin texture are reversible by switching the spontaneous electric polarization. This electric switching behavior relates to the tilting of PbBr6 octahedra and the reorientation of organic PA+ cations. Our studies on ferroelectric PST of 2D hybrid perovskites afford a platform for electrical spin texture manipulation.
Immunogenic Cell Death Inducing Metal Complexes for Cancer Therapy
Authors: Zhang Lingpu , Montesdeoca Nicolás , Karges Johannes , Xiao Haihua 
Published: February 2023

AbstractCancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are the leading causes of cancer‐associated deaths. While traditional treatments are able to efficiently remove the primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there is an urgent need for novel treatment modalities. Among the most promising approaches, increasing research interest has been devoted to immunogenic cell death inducing agents that are able to trigger localized cell death of the cancer cells as well as induce an immune response inside the whole organism. Preliminary studies have shown that immunogenic cell death inducing compounds could be able to overcome metastatic and relapsing tumors. Herein, the application of metal complexes as immunogenic cell death inducing compounds is systematically reviewed.
How to make a vampire
Authors: Smith Timothy D. , Prufrock Kristen A. , DeLeon Valerie B. 
Published: February 2023

AbstractHerein, we compared the developmental maturity of the cranium, limbs, and feeding apparatus in a perinatal common vampire bat relative to its mother. In addition, we introduce a method for combining two computed tomographic imaging techniques to three‐dimensionally reconstruct endocasts in poorly ossified crania. The Desmodus specimens were scanned using microcomputed tomography (microCT) and diffusible iodine‐based contrast‐enhanced CT to image bone and soft tissues. Muscles of the jaw and limbs, and the endocranial cavity were segmented using imaging software. Endocranial volume (ECV) of the perinatal Desmodus is 74% of adult ECV. The facial skeletal is less developed (e.g., palatal length 60% of adult length), but volumes for alveolar crypts/sockets of permanent teeth are nearly identical. The forelimb skeleton is uniformly less ossified than the distal hind limb, with no secondary centers ossified and an entirely cartilaginous carpus. All epiphyseal growth zones are active in the brachium and antebrachium, with the distal radius exhibiting the greatest number of proliferating chondrocytes arranged in columns. The hind limb skeleton is precociously ossified from the knee distally. The musculature of the fore limb, temporalis, and masseter muscles appear weakly developed (6–11% of the adult volume). In contrast, the leg and foot musculature is better developed (23–25% of adult volume), possibly enhancing the newborn's capability to grip the mother's fur. Desmodus is born relatively large, and our results suggest they are born neurally and dentally precocious, with generally underdeveloped limbs, especially the fore limb.
Long‐life high‐capacity lithium battery with liquid organic cathode and sulfide solid electrolyte
Authors: Peng Jian , Wu Dengxu , Li Hong , Chen Liquan , Wu Fan 
Published: February 2023

AbstractElectrochemical batteries with organic electrode materials have attracted worldwide attention due to their high safety, low cost, renewability, low contamination, and easiness of recycling. However, the practical application of such system is limited by low density, low electronic/ionic conductivity, and the dissolution of organic electrode materials in conventional liquid electrolytes. Herein, a novel battery configuration is proposed to replace liquid electrolyte/solid organic cathode with solid electrolyte/liquid organic cathode to ultimately solve the shuttle effect and dissolution problem of organic cathodes. More importantly, this configuration combines room‐temperature high‐safety liquid lithium metal anode Li‐BP‐DME that can essentially inhibit lithium dendrite nucleation/growth and sulfide SE with ultrahigh room‐temperature ionic conductivity for facilitated ion‐conduction.
Standard versus low‐dose nab‐paclitaxel in previously treated patients with advanced non‐small cell lung cancer: A randomized phase II trial (JMTO LC14‐01)
Authors: Takeuchi Susumu , Kubota Kaoru , Sugawara Shunichi , Teramukai Satoshi , Noro Rintaro , Fujikawa Kei , Hirose Takashi , Atagi Shinji , Minami Seigo , Iida Shinichiro , Kuraishi Hiroshi , Aiba Tomoiki , Minegishi Yuji , Matsumoto Masaru , Seike Masahiro , Gemma Akihiko , Kawahara Masaaki ,   Japan‐Multinational Trial Organization (JMTO)
Published: February 2023

AbstractBackgroundNab‐paclitaxel (nab‐PTX) has better transfer to tumor tissue than cremophor‐based paclitaxel. It suggests that the optimum dose of nab‐PTX might be lower than the dose and schedule that is widely used. We designed a randomized phase II trial to examine the clinical utility and safety of nab‐PTX in patients with previously treated advanced non‐small cell lung cancer (NSCLC).MethodsPatients were randomly allocated (1:1) to receive nab‐PTX monotherapy at 100 mg/m2 (group A) or 70 mg/m2 (group B). The primary endpoint was progression‐free survival (PFS). Secondary endpoints included overall survival (OS), objective response rate (ORR), and adverse events (AEs).ResultsFinally, 81 patients were randomized. Similar results were observed in both groups for PFS (3.75 vs. 3.71 months), OS (13.50 vs. 16.13 months), or ORR (20.5% vs. 23.1%). The incidences of grade 3 or worse AEs were 57.5% in group A and 41.5% in group B. The proportion of serious side effects was 10.0% in group A and 4.9% in group B.ConclusionBoth standard dose and low dose of nab‐PTX monotherapy are active for previously treated NSCLC patients with better safety profile. Therefore, nab‐PTX 70 mg/m2 dose and schedule in the trial would be a reasonable option.
Long‐term follow‐up results of pediatric and adolescent patients with localized Ewing sarcoma treated based on stratified modalities
Authors: Zeng Chenggong , Chen Tingting , Wang Juan , Sun Feifei , Huang Junting , Lu Suying , Zhu Jia , Zhang Yizhuo , Sun Xiaofei , Zhen Zijun 
Published: February 2023

AbstractBackgroundCompared with other pediatric tumors, little advances were achieved in studies on the stratified treatment in localized Ewing sarcoma. Most pediatric oncology groups treated Ewing sarcoma according to whether there was an existing metastasis, without involving more prognostic factors. In this study, patients with localized Ewing sarcoma were divided into resectable and unresectable groups at diagnosis and received chemotherapy with different intensity, for the purpose of achieving good efficacy, avoiding overtreatment and reducing unnecessary toxicity.MethodsA total of 143 patients with a median age of 10 years old diagnosed with localized Ewing sarcoma in this retrospective study were divided into two cohorts (Cohort 1, n = 42; Cohort 2, n = 101) and patients in Cohort 2 received chemotherapy with different intensity (Regimen 1, n = 52; Regimen 2, n = 49). Outcomes were analyzed using the Kaplan–Meier method to estimate event‐free survival (EFS) and overall survival (OS), and the curves were compared using the log‐rank test.ResultsThe 5‐year EFS and 5‐year OS for all the patients were 69.0% and 77.5%. The 5‐year EFS for Cohort 1 and Cohort 2 were 76.0% and 66.1% (p = 0.31), and the 5‐year OS were 83.0% and 75.1% (p = 0.30), respectively. In Cohort 2, the 5‐year EFS rate of patients treated with Regimen 2 was significantly higher than that of patients treated with Regimen 1 (74.5% vs. 58.3%, p = 0.03).ConclusionsAccording to whether a grossly complete resection was received at the time of diagnosis, localized Ewing sarcoma patients in this study were stratified into two groups and received different intensities of chemotherapy, which achieved good efficacy and avoided overtreatment and reduced unnecessary toxicity.