bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining the Mediator of Emotional Exhaustion and the Moderator of Work Support in the Association Between Person–Job Fit and Mental Health: Evidence from a Nationally Representative Sample of Social Workers in China
Authors: Jiang Shan , Liu Zewei , Nayilan Haimiti , Du Ruoyu , Wang Lin 
Published: June 2023

Abstract
Social workers’ mental health issues in China have contextually important meanings, which result from its situation of extensive development and limited resources, and result in more developmental problems in the next stage. To fill research gaps in perspectives, participants and empirical evidence, this study used the Conservation of Resources theory framework and a nationally representative sample to examine a moderated mediation model. A sample of 5,965 Chinese social workers was obtained from the China Social Work Longitudinal Study in 2019. The results indicated that the relation between person–job fit and social workers’ depression was partially mediated by their emotional exhaustion. In addition, the indirect effect was moderated by supervisor support, coworker support and manager support in the workplace. This study provides a resource-based mechanism to understand social workers’ mental health issues in the context of the developing world. Practical implications on improving social workers’ person–job fit, emotional exhaustion and work support were also discussed.
Skeletal muscle in amyotrophic lateral sclerosis
Authors: Shefner Jeremy M , Musaro Antonio , Ngo Shyuan T , Lunetta Christian , Steyn Frederik J , Robitaille Richard , De Carvalho Mamede , Rutkove Seward , Ludolph Albert C , Dupuis Luc 
Published: June 2023

Abstract
Amyotrophic lateral sclerosis (ALS), the major adult-onset motor neuron disease, has been viewed almost exclusively as a disease of upper and lower motor neurons, with muscle changes interpreted as a consequence of the progressive loss of motor neurons and neuromuscular junctions. This has led to the prevailing view that the involvement of muscle in ALS is only secondary to motor neuron loss. Skeletal muscle and motor neurons reciprocally influence their respective development and constitute a single functional unit. In ALS, multiple studies indicate that skeletal muscle dysfunction might contribute to progressive muscle weakness, as well as to the final demise of neuromuscular junctions and motor neurons. Furthermore, skeletal muscle has been shown to participate in disease pathogenesis of several monogenic diseases closely related to ALS.
Here, we move the narrative towards a better appreciation of muscle as a contributor of disease in ALS. We review the various potential roles of skeletal muscle cells in ALS, from passive bystanders to active players in ALS pathophysiology. We also compare ALS to other motor neuron diseases and draw perspectives for future research and treatment.
ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop
Authors: Han Sijia , Jin Xueying , Hu Tianyu , Chi Feng 
Published: June 2023

Abstract
Downregulation of ARHGAP25 was found in the tumor samples from breast cancer patients and five breast cancer cell lines. However, its precise role and molecular mechanisms in breast cancer remain completely unknown. Herein, we found that knockdown of ARHGAP25 in breast cancer cells promoted proliferation, migration and invasion of breast cancer cells. Mechanistically, ARHGAP25 silence facilitated the activation of the Wnt/β-catenin pathway and the upregulation of its downstream molecules (including c-Myc, Cyclin D1, PCNA, MMP2, MMP9, Snail and ASCL2) by directly regulating Rac1/PAK1 in breast cancer cells. In vivo xenograft experiments indicated ARHGAP25 silence promoted tumor growth and activated the Wnt/β-catenin pathway. In contrast, overexpression of ARHGAP25 in vitro and in vivo impeded all of the above cancer properties. Intriguingly, ASCL2, a downstream target of the Wnt/β-catenin pathway, transcriptionally repressed the expression of ARHGAP25 and therefore constituted a negative feedback loop. Moreover, bioinformatics analysis indicated that ARHGAP25 was significantly correlated with tumor immune cell infiltration and the survival of patients with different immune cell subgroups in breast cancer. Collectively, our work revealed that ARHGAP25 suppressed tumor progression of breast cancer. It provides a novel insight for the treatment of breast cancer.
Increasing social disparities in obesity among 15 000 pre-schoolers in a German district from 2009 to 2019
Authors: Michel Zora , Krayl Nele , Götz Katja , Wienke Andreas , Mikolajczyk Rafael , Führer Amand 
Published: June 2023

Abstract

Background
Although childhood obesity prevalence has stagnated in many high-income regions after decades of increase, it continues to be a major public health problem with adverse effects. The objective was to examine obesity trends as a function of parental social status to identify obesity disparities among children.

Methods
Data from school entry examinations from 2009 to 2019 of 14 952 pre-schoolers in one German district were used. Logistic regression models (obesity/overweight as dependent variable) and a linear regression [BMI z-score (BMIz) as dependent variable] were performed adjusted for social status and sex to investigate time trends in overweight and obesity.

Results
Overall, we found an increase of obesity over time [odds ratio (ORs): 1.03 per year, 95% CI: 1.01–1.06]. Children with low social status had an OR of 1.08 per year (95% CI: 1.03–1.13), while the trend was less expressed in children with high social status (OR: 1.03 per year, 95% CI: 0.98–1.08). The mean BMIz decreased per year (regression coefficient −0.005 per year, 95% CI: −0.01 to 0.0) when considering all children. This decrease was more pronounced in children with high social status (regression coefficient: −0.011 per year, 95% CI: −0.019 to −0.004), compared with a slight increase of 0.014 (95% CI: −0.003 to 0.03) per year among children with low social status. Also, children with low parental social status were heavier and smaller than their peers with high social status.

Conclusions
Although the mean BMIz decreased among pre-schoolers, obesity prevalence and status-related inequity in obesity prevalence increased from 2009 to 2019 in the region studied.
The cichlid pharyngeal jaw novelty enhances evolutionary integration in the feeding apparatus
Authors: Roberts-Hugghis Alexus S , Burress Edward D , Lam Brian , Wainwright Peter C 
Published: June 2023

Abstract
The modified pharyngeal jaw system of cichlid fishes is widely viewed as a key innovation that substantially facilitated the evolutionary exuberance of this iconic evolutionary radiation. We conduct comparative phylogenetic analyses of integration, disparity, and rate of evolution among feeding-related, skeletal structures in Neotropical cichlids and North American centrarchids, which lack the specialized pharyngeal jaw. Contrasting evolutionary patterns in these two continental radiations, we test a classic decoupling hypothesis. Specifically, we ask whether the modified pharyngeal jaw in cichlids resulted in enhanced evolutionary independence of the oral and pharyngeal jaws, leading to increased diversity of trophic structures. Contrary to this prediction, we find significantly stronger evolutionary integration between the oral and pharyngeal jaws in cichlids compared to centrarchids, although the two groups do not differ in patterns of integration within each jaw system. Further, though we find no significant differences in disparity, centrarchids show faster rates of morphological evolution. Our results suggest that the modified pharyngeal jaw resulted in less evolutionary independence and slower rates of evolution within the feeding system. Thus, we raise the possibility that the cichlid novelty enhances feeding performance, but does not prompt increased morphological diversification within the feeding apparatus, as has long been thought.
Newcomer perceptions of COVID-19 countermeasures in Canada
Authors: Koshy Liza , Burns Katie , Godinho Nascimento Maria H , Ike Nnenna Arianzu Uma , Herati Hoda , Filice Eric , Rotolo Bobbi , Betini Gustavo S , Ward Paul R , Dubé Ève , Meyer Samantha B 
Published: June 2023

Abstract
Newcomers to Canada have been disproportionally affected by COVID-19, with higher rates of infection and severity of illness. Determinants of higher rates may relate to social and structural inequities that impact newcomers’ capacity to follow countermeasures. Our aim was to describe and document factors shaping newcomers’ acceptance of COVID-19 countermeasures. Semi-structured qualitative interviews were conducted with individuals living in Canada for &lt;5 years. Participants were asked to discuss their pandemic experiences, and perceptions and acceptance of measures. Five themes were identified: (i) belief in the necessity and efficacy of countermeasures; (ii) negative impact of measures on health/wellbeing; (iii) existing barriers to newcomer settlement exacerbated by pandemic measures; (iv) countermeasure adherence related to immigration status and (v) past experiences shaping countermeasure acceptance. Government should continue to provide messaging regarding the importance of measures for individual and population heath and continue to demonstrate a commitment to the interests of citizens. Importantly, newcomer trust in government should not be taken for granted, as this trust is critical for the acceptance of government interventions now and moving forward. It will be important to ensure that newcomers are given support to overcome challenges to settlement that were intensified during the pandemic.
Development and validation of a new questionnaire to assess perceptions regarding DWELL: Design for WELLness
Authors: Aperman-Itzhak Tal , Prilleltensky Isaac , Rosen Laura 
Published: June 2023

AbstractDesigning home environments for health and wellness is a crucial strategy for disease prevention and health promotion. Yet, there is not a tool to evaluate perceptions regarding home design for health and wellness. This study aimed to develop and validate a new instrument to measure people’s perceptions regarding the concept of DWELL: Design for WELLness in the home environment. We developed a short 5-item online questionnaire to detect changes in knowledge, awareness, engagement and self-efficacy regarding DWELL. The instrument was validated in an online study. Of the 613 mothers who answered the questionnaire initially, 397 answered the questionnaire a second time. Factor analysis and Cronbach’s alpha indicated that all five DWELL questions load into one single factor (the model explained 61.84% of total variance), and measure a reliable scale of the same construct, with high levels of internal consistency (Cronbach’s α = 0.85) at both first and second administrations. Spearman correlations between DWELL first and second administrations of the questionnaire indicated moderate-to-high test–retest reliability (0.55–0.70, p &lt; 0.001). DWELL was found to be a valid tool which fills a gap in the public health literature. This measure serves as a free and convenient online instrument to gain insights regarding the effect of modifying environments for disease prevention and health promotion. The tool may be used to assess perceptions in the conditions leading wellness promotion in the home.
Australian young people’s perceptions of the commercial determinants of the climate crisis
Authors: Arnot Grace , Thomas Samantha , Pitt Hannah , Warner Elyse 
Published: June 2023

AbstractThere is increasing public health focus on how corporate practices impact population health and well-being. While the commercial determinants of the climate crisis pose serious threats to human and planetary health, governments largely seek to balance climate action with economic imperatives. Global stakeholders recognize that young people have important voices in influencing climate responses. However, few studies have investigated young people’s perceptions of the commercial determinants of the climate crisis. A qualitatively led online survey of n = 500 young Australians (15–24 years) investigated their understanding of corporate responses to the climate crisis, factors that influenced these responses and strategies to respond. A reflexive approach to thematic analysis was used. Three themes were constructed from the data. First, young people perceived that corporate responses to the climate crisis focussed on soft options and lacked meaningful action. Second, they stated that these responses were largely influenced by economic imperatives rather than planetary health, with policy levers needed to implement environmentally responsible corporate practices. Third, young people perceived that systems needed change to create demand for a cleaner environment, leading to improved practices. Young people have a clear understanding of the commercial determinants of the climate crisis and associated threats to population health. They recognize that corporate practices (and consumer demand) will not change without significant policy and structural change. Public health and health promotion stakeholders should work alongside young people to influence decision-makers to address harmful corporate behaviours.
(Un)belonging at work: an overlooked ingredient of workplace health
Authors: Thissen Lotte , Biermann-Teuscher Dorit , Horstman Klasien , Meershoek Agnes 
Published: June 2023

Abstract
Organizations offer activities and programmes to improve their employees’ health. These workplace health promotion (WHP) activities usually have an individualized and top-down focus, a low uptake among employees, and are perceived to be out of line with employees’ experiences and definitions of health. This paper follows up on studies that have broadened the focus of WHP by including social relations and delves deeper into how daily practices and experiences of (un)belonging at work relate to workplace health. Based on ethnographic research in two companies in the Netherlands, this paper analyses how (un)belonging is expressed and experienced by employees. The paper shows that employees define health at work as a social practice. It also demonstrates how dynamics at work shape different dimensions of (un)belonging that, in turn, affect employees’ perceived health at work. These findings indicate the importance of including (un)belonging in the workplace as an ingredient of WHP.
Attenuated Expression of SLCO2A1 Caused by DNA Methylation in Pediatric Inflammatory Bowel Disease
Authors: Ito Natsuki , Kudo Takahiro , Eguchi Hidetaka , Jimbo Keisuke , Furuhata Atsushi , Okuno Toshiaki , Takeuchi Ichiro , Arai Katsuhiro , Ishige Takashi , Okazaki Yasushi , Shimizu Toshiaki 
Published: June 2023

Abstract

Background
SLCO2A1 encodes a prostaglandin (PG) transporter, and autosomal recessive pathogenic variants of this gene cause chronic enteropathy associated with SLCO2A1. It is unclear whether a heterozygous pathogenic variant of SLCO2A1 has a role in the pathogenesis of other types of inflammatory bowel disease (IBD). In this study, we investigated the possible involvement of a local epigenetic alteration in SLCO2A1 in patients with a heterozygous pathogenic variant.

Methods
We conducted whole-exome sequencing of samples from 2 sisters with suspected monogenic IBD. In addition, we performed bisulfite sequencing using DNA extracted from their small and large intestine samples to explore epigenetic alterations.

Results
A heterozygous splicing site variant, SLCO2A1:c.940 + 1G &gt; A, was detected in both patients. To explore the possible involvement of epigenetic alterations, we analyzed protein and messenger RNA expression of SLCO2A1, and observed attenuated SLCO2A1 expression in the inflamed lesions of these patients compared with that in the control individuals. Furthermore, bisulfite sequencing indicated dense methylation in the promoter region of SLCO2A1 only in the inflamed lesions of both patients. The urinary PG metabolite levels in these patients were comparable to those in patients with chronic enteropathy associated with SLCO2A1 and higher than those in the control individuals. We found considerably higher levels of the metabolites in patient 1, who showed more severe symptoms than patient 2.

Conclusions
Local DNA methylation attenuated SLCO2A1 expression, which may evoke local inflammation of the mucosa by the unincorporated PG. These findings may improve our understanding of the epigenetic mechanisms underlying IBD development.
The Blow-Up Analysis on B2(1) Affine Toda System: Local Mass and Affine Weyl Group
Authors: Cui Leilei , Wei Jun-cheng , Yang Wen , Zhang Lei 
Published: June 2023

AbstractIt has been established that the local mass of blow-up solutions to Toda systems associated with the simple Lie algebras $\textbf{A}_{n}$, $\textbf{B}_{n}$, $\textbf{C}_{n}$, and $\textbf{G}_{2}$ can be represented by a finite Weyl group. In particular, at each blow-up point, after a sequence of bubbling steps (via scaling) is performed, the transformation of the local mass at each step corresponds to the action of an element in the Weyl group. In this article, we present the results in the same spirit for the affine $\textbf{B}_{2}^{(1)}$ Toda system with singularities. Compared with the Toda system with simple Lie algebras, the computation of local masses is more challenging due to the infinite number of elements of the affine Weyl group of type $\textbf{B}_{2}^{(1)}$. In order to give an explicit expression for the local mass formula, we introduce two free integers and write down all the possibilities into $8$ types. This shows a striking difference to previous results on Toda systems with simple Lie algebras. The main result of this article seems to provide the first major advance in understanding the relation between the blow-up analysis of affine Toda system and the affine Weyl group of the associated Lie algebras.
Improvement of the stability and catalytic efficiency of heparan sulfate N-sulfotransferase for preparing N-sulfated heparosan
Authors: Xi Xintong , Hu Litao , Huang Hao , Wang Yang , Xu Ruirui , Du Guocheng , Chen Jian , Kang Zhen 
Published: June 2023

Abstract
The chemo-enzymatic and enzymatic synthesis of heparan sulfate and heparin are considered as an attractive alternative to the extraction of heparin from animal tissues. Sulfation of the hydroxyl group at position 2 of the deacetylated glucosamine is a prerequisite for subsequent enzymatic modifications. In this study, multiple strategies, including truncation mutagenesis based on B-factor values, site-directed mutagenesis guided by multiple sequence alignment, and structural analysis were performed to improve the stability and activity of human N-sulfotransferase. Eventually, a combined variant Mut02 (MBP–hNST-NΔ599-602/S637P/S741P/E839P/L842P/K779N/R782V) was successfully constructed, whose half-life at 37°C and catalytic activity were increased by 105-fold and 1.35-fold, respectively. After efficient overexpression using the Escherichia coli expression system, the variant Mut02 was applied to N-sulfation of the chemically deacetylated heparosan. The N-sulfation content reached around 82.87% which was nearly 1.88-fold higher than that of the wild-type. The variant Mut02 with high stability and catalytic efficiency has great potential for heparin biomanufacturing.
A case of attenuated familial adenomatous polyposis in which genetic testing revealed that the children were asymptomatic gene carriers
Authors: Sonoda Hiromichi , Yamada Takeshi , Yamaguchi Tatsuro , Eguchi Hidetaka , Okazaki Yasushi , Yoshida Hiroshi , Ishida Hideyuki 
Published: June 2023

Abstract
Attenuated familial adenomatous polyposis, which accounts for ~10% of familial adenomatous polyposis, is difficult to diagnose because of its milder course and later onset. In both familial adenomatous polyposis and attenuated familial adenomatous polyposis, duodenal cancer is usually recognized 10–20 years after the diagnosis of colonic polyposis. We present herein a 66-year-old man who received pancreaticoduodenectomy due to ampullary carcinoma 17 years before onset of colonic polyposis. He then received extended right hemicolectoy for ascending colon cancer and ⁓100 polyps located from ceacum to splenic flexure of colon 2 years ago. The patient received Adenomatous polyposis coli (APC) genetic testing and detected a germline pathogenic frameshift variant in the APC gene (NM_000038.6:c.4875delA, ClinVar variant ID (127299)). The variant is classified as likely pathogenic according to the American College of Medical Genetics and Genomics guidelines. APC genetic testing was subsequently performed on his younger children (30 and 26 year old) and they found a same frameshift variant as his father. They were not detected any colonic polyposis by colonoscopy. This is a rare case report of attenuated familial adenomatous polyposis that diagnosed with gastric and colon polyposis &gt;10 years after the diagnosis of ampullary carcinoma and the first report of genetic diagnosis of an attenuated familial adenomatous polyposis variant in young relatives before the onset of the disease.
Clinical complete response maintained for more than 5 years after aggressive chemoradiotherapy for advanced rectal cancer with necrotizing fasciitis: a case report
Authors: Yoshikawa Yusuke , Suzuki Keiichi , Hashimoto Takeo , Omagari Kenshi , Sasaki Taketo , Tomita Yusuke , Tamura Akihiko 
Published: June 2023

Abstract
We report the case of a 65-year-old male diagnosed with advanced rectal cancer associated with necrotizing fasciitis (NF). Since radical surgery, total pelvic exenteration with sacrectomy, was rejected because of detrimental effects on quality of life, chemoradiotherapy (CRT) was chosen as anti-cancer treatment after urgent debridement. Although CRT was paused unintentionally just after delivering the total dose of radiation owing to the relapse of NF, the patient has maintained clinical complete response (cCR) without any distant metastasis for &gt;5 years. Advanced rectal cancer is recognized as an NF risk factor. No definitive treatment strategies have been reported for NF-inducing rectal cancer; however, some reports have demonstrated curative extended surgery. Thus, CRT may be a less-invasive treatment option for NF-inducing rectal cancer, whereas severe adverse effects including re-infection after debridement should be closely monitored.
OK432 sclerotherapy for refractory chylous leakage after neck dissection
Authors: Hashimoto Yuiko , Teshima Masanori , Yui Mitsuko , Tatehara Shun , Iritani Keisuke , Furukawa Tatsuya , Shinomiya Hirotaka , Nibu Ken-ichi 
Published: June 2023

Abstract
Chylous leakage is a rare but serious postoperative complication of neck dissection (ND). Most chylous leakages are successfully treated either by drainage or ligation of the thoracic duct, but the resolution is occasionally prolonged. OK432 sclerotherapy is used to treat various refractory cystic diseases of the head and neck. Three patients were treated with OK432 sclerotherapy for refractory chylous leakage following ND. Case 1 involved a 77-year-old man with chylous leakage after a total laryngectomy and bilateral ND. Case 2 involved a 71-year-old woman who underwent total thyroidectomy and left ND for thyroid cancer. Case 3 involved a 61-year-old woman who underwent right ND for oropharyngeal cancer. In all patients, chylous leakage rapidly improved after OK432 injection without any complications. Our results suggest the efficacy of OK432 sclerotherapy in patients with refractory chylous leakage after ND.