bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scope actuation system for articulated laparoscopes
Authors: Abdurahiman Nihal , Khorasani Mohammad , Padhan Jhasketan , Baez Victor M. , Al-Ansari Abdulla , Tsiamyrtzis Panagiotis , Becker Aaron T. , Navkar Nikhil V. 
Published: February 2023

Abstract
Background
An articulated laparoscope comprises a rigid shaft with an articulated distal end to change the viewing direction. The articulation provides improved navigation of the operating field in confined spaces. Furthermore, incorporation of an actuation system tends to enhance the control of an articulated laparoscope.

Methods
A preliminary prototype of a scope actuation system to maneuver an off-the-shelf articulated laparoscope (EndoCAMaleon by Karl Storz, Germany) was developed. A user study was conducted to evaluate this prototype for the surgical paradigm of video-assisted thoracic surgery. In the study, the subjects maneuvered an articulated scope under two modes of operation: (a) actuated mode where an operating surgeon maneuvers the scope using the developed prototype and (b) manual mode where a surgical assistant directly maneuvers the scope. The actuated mode was further assessed for multiple configurations based on the orientation of the articulated scope at the incision.

Results
The data show the actuated mode scored better than the manual mode on all the measured performance parameters including (a) total duration to visualize a marked region, (a) duration for which scope focus shifts outside a predefined visualization region, and (c) number of times for which scope focus shifts outside a predefined visualization region. Among the different configurations tested using the actuated mode, no significant difference was observed.

Conclusions
The proposed articulated scope actuation system facilitates better navigation of an operative field as compared to a human assistant. Secondly, irrespective of the orientation in which an articulated scope’s shaft is inserted through an incision, the proposed actuation system can navigate and visualize the operative field.
Reallocating sedentary time to physical activity: effects on fatigue and quality of life in patients with breast cancer in the Phys-Can project
Authors: Mazzoni Anne-Sophie , Strandberg Emelie , Börjeson Sussanne , Sjövall Katarina , Berntsen Sveinung , Demmelmaier Ingrid , Nordin Karin 
Published: February 2023

Abstract
Purpose
We aimed to investigate the effects of reallocating sedentary time to an equal amount of light (LPA) or moderate-to-vigorous intensity physical activity (MVPA) on cancer-related fatigue and health-related quality of life (HRQoL) in patients with breast cancer. We also aimed to determine the daily amount of sedentary time needed to be reallocated to LPA or MVPA to produce minimal clinically important changes in these outcomes.

Methods
Pooled baseline data from three studies were used, including women with breast cancer who participated in the Phys-Can project. Fatigue was assessed with the Multidimensional Fatigue Inventory questionnaire (MFI; five dimensions, 4–20 scale) and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire (EORTC QLQ-C30; 0–100 scale). Sedentary time and physical activity were measured with accelerometry. Isotemporal substitution modelling was used for the analyses.

Results
Overall, 436 participants (mean age 56 years, fatigue 11 [MFI], HRQoL 66 [EORTC QLQ-C30], LPA 254 min/day, MVPA 71 min/day) were included. Fatigue significantly decreased in two MFI dimensions when reallocating 30 min/day of sedentary time to LPA: reduced motivation and reduced activity (β =  − 0.21). Fatigue significantly decreased in three MFI dimensions when reallocating 30 min/day of sedentary time to MVPA: general fatigue (β =  − 0.34), physical fatigue (β =  − 0.47) and reduced activity (β =  − 0.48). To produce minimal clinically important changes in fatigue (− 2 points on MFI), the amount of sedentary time needed to be reallocated to LPA was ≈290 min/day and to MVPA was ≥ 125 min/day. No significant effects were observed on HRQoL when reallocating sedentary time to LPA or MVPA.

Conclusions
Our results suggest that reallocating sedentary time to LPA or MVPA has beneficial effects on cancer-related fatigue in patients with breast cancer, with MVPA having the greatest impact. In relatively healthy and physically active breast cancer populations, a large amount of time reallocation is needed to produce clinically important changes. Future studies are warranted to evaluate such effects in broader cancer populations.
Trial registration: NCT02473003 (10/10/2014) and NCT04586517 (14/10/2020).
Prediction of successful revision surgery for mesh-related complaints after inguinal hernia and pelvic organ prolapse repair
Authors: Van Rest K. L. C. , Gielen M. J. C. A. M. , Warmerdam L. M. , Kowalik C. R. , Roovers J. P. W. R. , Zwaans W. A. R. 
Published: February 2023

Abstract
Purpose

With this retrospective case series, we aim to identify predictors for reduction of pain after mesh revision surgery in patients operated for inguinal hernia or pelvic organ prolapse with a polypropylene implant. Identifying these predictors may aid surgeons to counsel patients and select appropriate candidates for mesh revision surgery.

Methods

Clinical records before and after mesh revision surgery from 221 patients with chronic postoperative inguinal pain (CPIP) and 59 patients with pain after pelvic organ prolapse (POP) surgery were collected at two experienced tertiary referral centers. Primary outcome was patient reported improvement of pain after revision surgery. A multivariable logistic regression model was used to specify predictors for pain reduction.

Results

The multivariable logistic regression was performed for each patient group separately. Patients with CPIP had higher chances of improvement of pain when time between mesh placement and mesh revision surgery was longer, with an OR of 1.19 per year. A turning point in chances of risks and benefits was demonstrated at 70 months, with improved outcomes for patients with revision surgery ≥ 70 months (OR 2.86). For POP patients, no statistically significant predictors for reduction of pain after (partial) removal surgery could be identified.

Conclusion
A longer duration of at least 70 months between implantation of inguinal mesh and revision surgery seems to give a higher chance on improvement of pain. Caregivers should not avoid surgery based on a longer duration of symptoms when an association between symptoms and the location of the mesh is found.
Constrained composite optimization and augmented Lagrangian methods
Authors: De Marchi Alberto , Jia Xiaoxi , Kanzow Christian , Mehlitz Patrick 
Published: February 2023

AbstractWe investigate finite-dimensional constrained structured optimization problems, featuring composite objective functions and set-membership constraints. Offering an expressive yet simple language, this problem class provides a modeling framework for a variety of applications. We study stationarity and regularity concepts, and propose a flexible augmented Lagrangian scheme. We provide a theoretical characterization of the algorithm and its asymptotic properties, deriving convergence results for fully nonconvex problems. It is demonstrated how the inner subproblems can be solved by off-the-shelf proximal methods, notwithstanding the possibility to adopt any solvers, insofar as they return approximate stationary points. Finally, we describe our matrix-free implementation of the proposed algorithm and test it numerically. Illustrative examples show the versatility of constrained composite programs as a modeling tool and expose difficulties arising in this vast problem class.
Supply chain integration in mass customization
Authors: Shen Bin , Zhang Jianing , Cheng Ming , Guo Shu , He Renlong 
Published: February 2023

Abstract
New technology such as 3D printing, robotic manufacturing, and the Internet of things can shorten the production time of mass customization (MC) products, enhance the self-design fun of consumers, and improve channel integration connectivity. In this study, we examine the impact of MC waiting time and self-design fun from the purchase of MC products on supply chain integration. We consider a supply chain consisting of one manufacturer, one retailer, and one customizer. The manufacturer produces and sells standardized products through the retailer, whereas the customizer sells customized products to consumers directly. The customizer can decide whether to integrate with the manufacturer (i.e., manufacturer–customizer integration) or with the retailer (i.e., retailer–customizer integration). We find that manufacturer–customizer integration can achieve a win–win–win outcome for all three supply chain members when the MC waiting time is within a moderate range and the probability of consumers being satisfied with the product quality is high, but retailer–customizer integration cannot achieve such an outcome, as the manufacturer will not be benefited if it does not participate in the integration. Furthermore, integration reduces the customizer’s investment in the level of self-design fun, which implies that the negative effect owing to the low level of self-design fun in the supply chain integration can be compensated by the competition mitigation effect owing to supply chain integration. With endogenized self-design fun, the achievability of a win–win–win outcome for all three supply chain members in the manufacturer–customizer integration will remain unchanged.
Sleep-Directed Hypnosis Improves Subjective Sleep Quality but not Extinction Memory After Exposure to Analog Trauma
Authors: Friesen Edith , Sopp M. Roxanne , Cordi Maren J. , Rasch Björn , Michael Tanja 
Published: February 2023

Abstract
Background
Evidence-based treatments of posttraumatic stress disorder (PTSD) aim to promote fear extinction learning. Post-learning sleep, particularly slow wave sleep (SWS), promotes memory consolidation and recall. Thus, boosting SWS might strengthen extinction recall. The current study investigated whether sleep-directed hypnosis designed to increase SWS and sleep quality improves extinction recall and reduces analog PTSD symptoms.

Method
In two subsamples (remote/laboratory), 211 healthy individuals underwent fear conditioning with a traumatic film clip. On the next evening, they underwent extinction training. Thereafter, the experimental group received sleep-directed hypnosis, whereas the control group listened to a control text. Extinction recall and generalization and film-related intrusions and rumination were assessed on the following morning.

Results
Subjective sleep quality declined following exposure to an aversive film. No group differences were found in SWS though exploratory analyses indicated less rapid eye movement sleep after hypnosis. After hypnosis, the experimental group reported improved sleep quality, whereas the control group showed a further deterioration. Hypnosis had no effects on extinction retention and generalization nor on analog intrusions and rumination.

Conclusion
The current results indicate that sleep-directed hypnosis may be beneficial for improving subjective sleep quality after trauma but not for enhancing extinction memory and reducing analog PTSD symptoms.
Stress-Related Exhaustion, Polygenic Cognitive Potential, and Cognitive Test Performance – A General Population Study
Authors: Ketvel Laila , Keltikangas-Järvinen Liisa , Pahkala Katja , Juonala Markus , Ahola-Olli Ari , Lehtimäki Terho , Viikari Jorma , Raitakari Olli , Rovio Suvi , Saarinen Aino 
Published: February 2023

Abstract
Background
We investigated whether stress-related exhaustion (chronic or short-term, and co-occurring with depression or not) is related to cognitive performance and whether polygenic cognitive potential modifies these associations.

Methods
The participants were from the Young Finns Study (N = 541–1273). Stress-related exhaustion was assessed using the Maastricht Questionnaire, depressive symptoms with the Beck Depression Inventory, and cognitive performance with subtests of the Cambridge Neuropsychological Test Automated Battery, measuring visuospatial learning, reaction time, sustained attention, and executive function. Cognitive performance and depression were assessed in 2011, and exhaustion in 2001, 2007, and 2011. A polygenic score for cognitive potential was calculated based on a GWAS on intelligence.

Results
High stress-related exhaustion, especially chronic, was associated with slower reaction time. Only clinical levels of depression were related to slower reaction time. Polygenic cognitive potential did not modify these associations. There were no differences in cognitive performance between individuals with co-occurring exhaustion and depression vs. those with only either condition.

Conclusion
Stress-related exhaustion, especially if chronic, seems to relate to slower reactions. Co-occurring exhaustion and depression may not have additive effects on cognitive performance. High polygenic cognitive potential may not protect from or predispose to harmful effects of exhaustion or depression on reaction time.
Progress on Levitating a Sphere in Cryogenic Fluids
Authors: Arrayás M. , Bettsworth F. , Haley R. P. , Schanen R. , Trueba J. L. , Uriarte C. , Zavjalov V. V. , Zmeev D. E. 
Published: February 2023

AbstractWe present the working prototype of a levitation system designed for investigation of flows in cryogenic helium fluids. The current device allows the levitation of a superconducting sphere and has several provisions made for allowing precise control over its motion. We report on progress in the detection and control systems of the prototype and demonstrate how uniform circular motion can be implemented.
A Dutch Study of Remarkable Recoveries After Prayer: How to Deal with Uncertainties of Explanation
Authors: Bendien Elena , Kruijthoff Dirk J. , van der Kooi Cornelis , Glas Gerrit , Abma Tineke 
Published: February 2023

AbstractThis article addresses cases of remarkable recoveries related to healing after prayer. We sought to investigate how people who experienced remarkable recoveries re-construct and give meaning to these experiences, and examine the role that epistemic frameworks available to them, play in this process. Basing ourselves on horizontal epistemology and using grounded theory, we conducted this qualitative empirical research in the Netherlands in 2016–2021. It draws on 14 in-depth interviews. These 14 cases were selected from a group of 27 cases, which were evaluated by a medical assessment team at the Amsterdam University Medical Centre. Each of the participants had experienced a remarkable recovery during or after prayer. The analysis of the interviews, which is based on the grounded theory approach, resulted in three overarching themes, placing possible explanations of the recoveries within (1) the medical discourse, (2) biographical discourse, and (3) a discourse of spiritual and religious transformation. Juxtaposition of these explanatory frameworks provides a way to understand better the transformative experience that underlies remarkable recoveries. Uncertainty regarding an explanation is a component of knowing and can facilitate a dialogue between various domains of knowledge.
Rectal use of levetiracetam: best practice report for a stepwise approach for sustainable off-label decision making and treatment
Authors: Rémi Constanze , Hermann Alina , Krull Elisabeth , Ockert-Schön Franziska , Rémi Jan 
Published: February 2023

AbstractOff-label drug use is common practice in palliative care. It may pose a risk to the patient and benefit should outweigh harm. A decision and documentation aid for off-label use was developed to support practitioners in clinical practice off-label use. Using the example of the rectal administration of levetiracetam in three patient cases, the utilisation and benefits of the decision and documentation aid are presented and discussed. The rectal administration of levetiracetam clearly is an experimental treatment approach with little underlying evidence. To support and document the decision-making process for or against such an off-label use in clinical practice, it is helpful to have a structured approach in order to make this data comprehensible for a later point in time. Off-label use may be a permissible treatment alternative without underlying evidence, provided it takes place in a well-planned and well-monitored therapeutic setting and the benefits outweigh the potential risks.
A fast epigraph and hypograph-based approach for clustering functional data
Authors: Pulido Belén , Franco-Pereira Alba M. , Lillo Rosa E. 
Published: February 2023

AbstractClustering techniques for multivariate data are useful tools in Statistics that have been fully studied in the literature. However, there is limited literature on clustering methodologies for functional data. Our proposal consists of a clustering procedure for functional data using techniques for clustering multivariate data. The idea is to reduce a functional data problem into a multivariate one by applying the epigraph and hypograph indexes to the original curves and to their first and/or second derivatives. All the information given by the functional data is therefore transformed to the multivariate context, being informative enough for the usual multivariate clustering techniques to be efficient. The performance of this new methodology is evaluated through a simulation study and is also illustrated through real data sets. The results are compared to some other clustering procedures for functional data.
Agricultural and innovation policies aimed at mitigating climate change
Authors: Puertas Rosa , Marti Luisa , Calafat Consuelo 
Published: February 2023

Abstract
The EU supports agricultural policies to help farmers meet the challenges of climate change (CC) by promoting more sustainable and environmentally friendly practices. This study focuses on the European primary sector (agriculture, forestry, and fisheries), productive activities that meet humanity’s basic needs, although this sector does not account for a dominant share of GDP. The analysis uses a panel data sample of 22 European countries for the period 2012–2019, and seeks to answer the following research questions: Is there a direct relationship between agricultural innovation efficiency and the technological advances implemented? What effect do GHG emissions and innovation efficiency have on CC? Which agricultural practices have the greatest effect on the volume of GHG emissions? The results indicate that the European primary sector has registered an average rise in productivity of 4%, mainly driven by technological improvements. This underscores the need for agricultural innovation policies that focus not only on improving aspects related to technology but also on making better use of existing resources. In addition, the econometric models estimated confirm that efficiency levels are the most influential determinants of temperature change, while GHG emissions are primarily explained by their own historical values. Ultimately, research and development is a tool that can be used to curb CC, along with the proper use of land and fertilizers. There is thus a need to foster novel agricultural practices that help reduce emissions while ensuring the efficiency of the sector.
Selective removal of ammonia from wastewater using Cu(II)-loaded Amberlite IR-120 resin and its catalytic application for removal of dyes
Authors: El-Ghobashy Marwa A. , Khamis Mohamed M. , Elsherbiny Abeer S. , Salem Ibrahim A. 
Published: February 2023

AbstractCationic ligand exchange is one of the most predominant mechanisms for the removal of ammonia from wastewater through complex formation. The complexation technique occurs between the metal ions loaded on the surface of Amberlite IR-120 and ammonia which is present in the medium. Cu(II)-loaded Amberlite IR-120 (R-Cu2+) was prepared and described using FT-IR, TGA, SEM, and EDX techniques. The prepared R-Cu2+ was applied for the elimination of ammonia from an aqueous solution. Different cations such as Co2+ and Ni2+ were loaded onto Amberlite IR-120 to study the impact of counter cation on the removal efficiency of ammonia. The ammonia removal percentage followed the order; R-Cu2+  > R-Ni2+  > R-Co2+. The effects of contact time, pH, initial concentration, temperature, and coexisting ions on the removal of ammonia from wastewater by R-Cu2+ were investigated. The equilibrium adsorbed amount of ammonia was found to be 200 mg/g at pH = 8.6 and 303 K within 60 min using 0.1 g R-Cu2+ and an initial concentration of ammonia of 1060 mg/L. The removal of ammonia using R-Cu2+ obeyed the non-linear plot of both Freundlich and Langmuir isotherms. According to the thermodynamic parameters, the adsorption of ammonia onto R-Cu2+ was an endothermic and spontaneous process. The time-adsorption data followed the pseudo-second-order and intraparticle diffusion models. Moreover, the resulting product (R-Cu(II)-amine composite) from the adsorption process exhibited high catalytic activity and could be low-cost material for the elimination of dyes such as aniline blue (AB), methyl green (MG), and methyl violet 2B (MV2B) from wastewater.
Graphical Abstract
Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study
Authors: Liu Dan , Aziz N. Ahmad , Pehlivan Gökhan , Breteler Monique M. B. 
Published: February 2023

Abstract
Individuals with a similar chronological age can exhibit marked differences in cardiovascular risk profiles, but it is unknown whether this variation is related to different rates of biological aging. Therefore, we investigated the relation between nine domains of cardiovascular function and four epigenetic age acceleration estimators (i.e., AgeAccel.Horvath, AgeAccel.Hannum, AgeAccelPheno, and AgeAccelGrim), derived from DNA methylation profiles. Among 4194 participants (mean age 54.2 years (range 30.0–95.0)) from the Rhineland Study, an ongoing population-based cohort study in Bonn, Germany, epigenetic age acceleration increased by 0.19–1.84 years per standard deviation (SD) increase in cardiovascular risk across multiple domains, including measures of kidney function, adiposity, and a composite cardiovascular risk score. Measures of inflammation and glucose homeostasis were associated with AgeAccel.Hannum, AgeAccelPheno, and AgeAccelGrim, but not with AgeAccel.Horvath. Moreover, effect sizes were larger for AgeAccelPheno and AgeAccelGrim than for AgeAccel.Horvath and AgeAccel.Hannum. Similarly, epigenetic age acceleration increased by 0.15–0.81 years per SD increase in markers of vascular function (blood pressure, arterial stiffness, and hemodynamic measures), whereas better endothelial function was only associated with lower AgeAccelGrim. Most effects on epigenetic age acceleration were independent, which suggests they independently contribute to different rates of biological aging.