bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of pyroptosis‐related clusters for prediction of overall survival and characterization of tumor microenvironment infiltration in laryngeal squamous cell carcinoma
Authors: Du Wei , Xia Xueming , Yu Jiayun , Shao Bin 
Published: March 2023

AbstractLaryngeal squamous cell carcinoma (LSCC) accounts for one‐third of head and neck squamous carcinoma (HNSCC). Although improvements have been made in treatments, the prognosis of patients with LSCC is unsatisfactory. Pyroptosis creates an environment that inhibits tumor growth in various cancers, but pyroptosis regulation in the tumor immune microenvironment in LSCC remains little known. The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to collect clinical traits and gene expression data of LSCC patients. We present a systematic overview of the immune microenvironment of LSCC based on genetics and transcriptional profiles of pyroptosis‐related genes (PRGs) and divide 220 LSCC into three distinct PRGclusters. Based on the three survival‐related PRGs identified in Lasso‐penalized Cox regression, samples from the training and validation cohorts were divided into two discrete geneClusters. We construct a prognostic model based on Risk score, quantify pyroptosis level and link it with patient outcome. Furthermore, we verified the expression level of one prognostic gene Basic Leucine Zipper ATF‐Like Transcription Factor at the tissue level in the validation experiment. These findings reveal the crucial role of pyroptosis and can assist in predicting patient prognosis, guiding optimal treatment choices, and developing new immunotherapies for LSCC.
An ultra‐wideband high gain antenna with embedded sleeves and hexagonal cavity
Authors: Zhang Honglin , Ye Jianhao , Liao Shaowei , Hu Bin‐Jie 
Published: March 2023

AbstractRadar detection and imaging systems need ultra‐wideband, high‐gain antennas to improve depth resolution and detection range. This paper proposes an ultra‐wideband high gain differential patch antenna having a peak gain of 12.9 dBi and an average gain of 11.3 dBi in the bandwidth from 7.2 and 26 GHz. Two sleeves are added around the feeding probes to attain ultra‐wideband impedance matching that is explained with an equivalent circuit. A hexagonal cavity with two M‐shaped cutouts improves the gain in the broadside direction by redistributing the current and reshaping the antenna's radiation patterns at different frequencies. The antenna's measured S‐parameter validates the design and confirms it has an ultra‐wide bandwidth. The ultra‐wide bandwidth along with the high gain values make the antenna a promising candidate for high‐resolution radar systems.
Lipid‐Laden Macrophage Index as a Diagnostic Tool for Pediatric Aspiration: A Systematic Review
Authors: Lawlor Claire M. , Choi Sukgi S. 
Published: March 2023

AbstractObjectiveLipid‐laden macrophage index (LLMI) has been proposed as a marker for aspiration on bronchoalveolar lavage. It has also been studied as a marker for gastroesophageal reflux and other pulmonary diseases. This review aims to determine the clinical correlation between LLMI and pediatric aspiration.Data SourcesPubMed (MeSH search), Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL) portals through December 17th, 2020.Review MethodsPreferred Reporting Items for Systematic Review and Meta‐Analysis criteria were followed, and a quality assessment of included studies was performed using the Methodological Index for Non‐Randomized Studies. Search criteria included all occurrences in the title or abstract of the terms “pulmonary aspiration” and “alveolar macrophages.”ResultsFive studies describing 720 patients met inclusion, 3 retrospective case‐control studies, and 2 prospective observational studies. Four studies suggested a link between elevated LLMI and aspiration, and 1 found no association. Control groups varied and included healthy nonaspirators to nonaspirators with other pulmonary diseases. Diagnosis of aspiration was not standardized across the studies. Three papers proposed cutoff values for LLMI, all different.ConclusionThe existing literature indicates that LLMI is not a sensitive or specific marker for aspiration. Further study is needed to define the utility of LLMI in pediatric aspiration.
Pathogenesis, clinical features, and phenotypes of pulmonary hypertension associated with interstitial lung disease: A consensus statement from the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative ‐ Group 3 Pulmonary Hypertension
Authors: Piccari Lucilla , Allwood Brian , Antoniou Katerina , Chung Jonathan H. , Hassoun Paul M. , Nikkho Sylvia M. , Saggar Rajan , Shlobin Oksana A. , Vitulo Patrizio , Nathan Steven D. , Wort Stephen John 
Published: March 2023

AbstractPulmonary hypertension (PH) is a frequent complication of interstitial lung disease (ILD). Although PH has mostly been described in idiopathic pulmonary fibrosis, it can manifest in association with many other forms of ILD. Associated pathogenetic mechanisms are complex and incompletely understood but there is evidence of disruption of molecular and genetic pathways, with panvascular histopathologic changes, multiple pathophysiologic sequelae, and profound clinical ramifications. While there are some recognized clinical phenotypes such as combined pulmonary fibrosis and emphysema and some possible phenotypes such as connective tissue disease associated with ILD and PH, the identification of further phenotypes of PH in ILD has thus far proven elusive. This statement reviews the current evidence on the pathogenesis, recognized patterns, and useful diagnostic tools to detect phenotypes of PH in ILD. Distinct phenotypes warrant recognition if they are characterized through either a distinct presentation, clinical course, or treatment response. Furthermore, we propose a set of recommendations for future studies that might enable the recognition of new phenotypes.
Quantum‐Based Magnetic Field Sensors for Biosensing
Authors: Bao Bo , Hua Yu , Wang Ridong , Li Dachao 
Published: March 2023

AbstractThe accurate detection of very weak biomagnetic signals with a sensitivity of fT levels and mapping nanoscale magnetic field variations are two of the most significant challenges for biosensing. Compared to the limited sensitivity and spatial resolution of traditional magnetic field sensors, quantum‐based magnetic field sensors are emerging as a promising solution. In this review, the latest developments of three representative quantum‐based magnetic field sensors, including superconducting quantum interference device (SQUID) magnetometers, spin exchange relaxation free (SERF) atomic magnetometers, and nitrogen‐vacancy centers in diamond, are summarized. Both virtues and limitations of these sensors are analyzed systematically, and typical applications in magnetocardiography, magnetoencephalography, detection of neuronal action potentials, magnetic imaging of living cells, biomedical diagnosis, etc., are presented. Furthermore, SQUIDs combined with microfluidics for magnetic immunoassay diagnostics, the chip‐scale SERF atomic magnetometers fabricated by microelectromechanical systems that offer wearable flexibility, and nanodiamonds functionalized with magnetic nanoparticles to improve the sensitivity of nanothermometers are discussed.
Cough remedy leading to chronic cough: An unusual airway foreign body‐Clove
Authors: Varunn M. D. , Jayakumar R. , Tarke Chandrakant , Juvva Kishan Srikanth , Senthil D. 
Published: March 2023

AbstractThe spectrum of presentation of airway foreign body can vary from having mild symptoms to sudden death. Smaller foreign body in distal airways, especially if the patient is unaware of aspiration can result in chronic symptoms mimicking asthma. Clove, has been used traditionally for its medicinal values and commonly used as a cough remedy. In this case series, we report four cases of this unusual airway foreign body which were essentially consumed with an intention to prevent cough, but unfortunately became the reason for their cough.
Robust H∞ control for switched stochastic nonlinear systems under sampled‐data
Authors: Zhao Hongpeng , Wang Jing , Huang Dan 
Published: March 2023

AbstractIn this article, we consider an output feedback control problem of switched stochastic nonlinear systems under sampled‐data, where the switching converts to asynchronous switching if the switching occurs within the sampling interval. We first construct the output feedback sampled‐data controller by the back‐stepping method. And the limiting conditions of the sampling period are obtained based on the average dwell time method. We show that the closed‐loop system is globally mean‐square asymptotically stable and has a weighted ‐gain. Moreover, our theoretical results are applied to two numerical examples to demonstrate the validity of the proposed method.
Expressing Enhanced Inhibitory Effects toward Arachidonic Acid Induced Platelet Activation: Design, Synthesis, DFT Calculations and in vitro Evaluation of Imatinib Analogues
Authors: Kosma Anna , Pantazi Despoina , Voulgari Pinelopi , Ntemou Nikoleta , Brentas Alexios , Alivertis Dimitrios , Siskos Michael G. , Tselepis Alexandros D. , Skobridis Konstantinos 
Published: March 2023

AbstractEncouraged by the excellent antiplatelet properties of novel imatinib and nilotinib analogues in our previous study and based on a fact that slight structural changes, such as the incorporation of different substituents at the final phenyl ring of imatinib and nilotinib, have a strong impact on their antiplatelet potency, two pairs of constitutional isomers of the imatinib analogues 1, 2 and 3, 4, have been designed, synthesized and evaluated for their antiplatelet characteristics. The structure geometry of the imatinib analogues 1–4 and NBO (Natural Bond Orbital) charges of the lower energy conformation each of the analogues were explored by DFT. Molecular docking studies were also performed. All compounds were less efficient in inhibiting platelet aggregation induced by ADP or TRAP‐6 in comparison with arachidonic acid (AA). Similar results were obtained for the membrane expression of P‐selectin. The most active compound was also tested to inhibit c‐Src kinase. The present study demonstrates that appropriate modifications of the imatinib structure, may confer on this molecule potent antiplatelet characteristics.
Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies
Authors: Azeem Shakil Muhammad , Ullah Saeed , Raza Shah Syed , Al‐Harrasi Rashid , Khan Ajmal , Al‐Harrasi Ahmed , Anwar Muhammad U. , Powell Annie K. 
Published: March 2023

AbstractThree one‐pot reactions leading to six new transition metal complexes are presented. The one‐pot reactions involved transformations of 2‐(N’‐dicyanomethylene‐hydrazino)‐benzoic acid (DHB) into three new ligands (Lig‐I)2−, (Lig‐II)2−, and (Lig‐III)2−. The complex [Ni2(Lig‐I)2] ⋅ 3H2O (1) was prepared in a one‐pot synthesis in which ligand, (Lig‐I)2− was formed by the amination of DHB resulting from the nucleophilic attack of an amino group of ethylenediamine (en). The complex [Cu(Lig‐II)(en)(H2O)] (2) was prepared in a one‐pot synthesis in which ligand, (Lig‐II)2− was formed by the nucleophilic attack of an amino group of en resulting in an imidazole ring formation. The dinunclear complexes [Zn2(Lig‐III)2(CH3OH)2] (3) and [Cu2(Lig‐III)2(CH3OH)2] (4), a linear trinuclear complex [Ni3(Lig‐III)(en)2(CH3OH)] (5), and a mononuclear complex [Mn(Lig‐III)(CH3OH)4] (6) were synthesized using a preparation involving conversion of one of the nitriles on DHB into an imino‐ester. The resulting complexes were characterized using a variety of analytical techniques including infra‐red and UV‐vis spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction analysis. The complexes displayed α‐glucosidase enzyme inhibition with IC50 values in the range of 1.57–207 μM.
Magnetic Polyeugenol Nanoparticles as a New Sorbent for Solid‐Phase Extraction of Polycyclic Aromatic Hydrocarbons in Environmental Water and Food Samples
Authors: Rezaei Mahdie , Mehdinia Ali , Shemirani Farzaneh 
Published: March 2023

AbstractIn this study, the magnetized polyeugenol was applied as an efficient adsorbent for pre‐concentration of five target polycyclic aromatic hydrocarbons (PAHs), acenaphthene, fullerene, phenanthrene, fluoranthene and pyrene, in the aqueous samples. Fourier transform infrared spectroscopy, field emission scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, transmission electron microscopy, thermo‐gravimetric and zeta‐potential analyses, and vibration sample magnetometry were utilized for characterization of the prepared nanocomposite. Key parameters in the extraction efficiency of PAHs including pH, salt content, adsorbent amount, extraction time and volume of desorption solvent were optimized. Under the optimal conditions, a linear response was observed in the concentration range of 1–75 μg L−1 (R2=0.9980–0.9994). The reasonable relative standard deviations (RSDs) from 3.46 to 5.74 (n=3) were also obtained. The enrichment coefficients were calculated to be 17 as the minimum and 20 as the maximum. The obtained limits of detection and limit of quantitation were respectively in range of 0.09–0.19 μg L−1 and 0.32–0.56 μg L−1. Finally, the adsorbent was used to measure the PAHs content of real samples including tap water, river water and brewed tea. The recoveries were between 80.0 %–100.4 % (for tap water) and 91.1 %–100.5 % (for river water) and 83.4 %–102.1 % (for tea sample).
Construction of A Novel 2D/1D/‐2D RP/BP‐Bi2WO6 Composite with In Situ Junction and Z‐scheme System for Enhanced Photocatalytic H2 and H2O2 Production
Authors: Zeng Yating , Fu Hanping , Liu Liran , Feng Li , Zhang Tianxiang , Liang Qingshuang , Xiao Xiufeng 
Published: March 2023

AbstractExploring multifunctional photocatalysts with rational design and construction of unique transport channels is of great significance for the value‐added chemicals production and environmental remediation. In this work, a novel 2D/1D/‐2D RP/BP‐MBWO dual heterostructure photocatalyst has been successfully synthesized by loading the in‐situ grown 2D/1D RP/BP heterostructure on the 2D Bi2WO6 nanosheets. through simple ultrasonic agitation.Benefiting from this favourable interfacial and structural characteristics, the fabricated BP/RP‐MBWO photocatalyst shows a sharply improved photocatalytic H2 and H2O2 evolution performance. Excitingly, the optimal of H2O2 production rate of the BP/RP‐Bi2WO6 composites is as high as 622.5 μmol g−1 h−1 under visible light irradiation, which is approximately 15 times as that of pure MBWO. The hydrogen production performance of the complexes was significantly improved compared to the pure MBWO samples. When the BP/RP loading was 20 %, the prepared nanocomposites showed the highest photocatalytic hydrogen evolution efficiency with the hydrogen production rate of about 0.77 μmol ⋅ g−1 ⋅ h−1. This work is expected to offer a new inspiration for the rational design and construction of effcient photocatalyst systems toward solar energy capture and conversion.
Palladium‐Catalysed C−C Bond Forming 4‐Cyanophenyl‐nicotinamide Conjugates; Anti‐Pancreatic Cancer Screening on Capan‐1 Cell Line
Authors: Rahman Abdul , Belur Ningegowda Nippu , Kammathalli Siddappa Manjunatha , Kumar Jain Sandeep , Malleshappa Kumaraswamy Honnenahally , Achur Rajeshwara , Devappa Satyanarayan Nayak , Malavalli Mahadevan Kittappa 
Published: March 2023

AbstractPancreatic cancer is the most severe, as a consequence of asymptomatic nature and ineffective therapies among all malignancies. Nicotinamides are effective ring systems in the treatment of pancreatic cancer with their wide range of applications. In the present investigation, nicotinamide and 4‐cyanophenyl ring systems are brought together to obtain greater potency. For the process of investigation, PARP1 protein is targeted and evaluated by docking at the active site to determine the protein‐ligand interaction, revealed the potential with the binding affinity of −9.0 to −11.0 Kcal/mol to inhibit the poly ADP‐ribose polymerase 1 (PARP1) pathway. The MTT‐assay assessment of a synthesized series has been performed against Capan‐1 pancreatic cancer cell line. The nicotinamide compounds demonstrated a significant inhibitory effect over Capan‐1 cell line, and 6‐(4‐cyanophenyl)‐N‐(3‐phenylpropyl)nicotinamide exhibited as a potential lead for the development of novel chemotherapeutics against pancreatic cancer.
Synthesis of Quinoline‐Thiazolidine‐2,4‐dione Coupled Pyrazoles as in vitro EGFR Targeting Anti‐Breast Cancer Agents and Their in silico Studies
Authors: Bangaru Mallikarjuna , Kumar Nukala Satheesh , Kannekanti Praveen Kumar , Sirassu Narsimha , Manchal Ravinder , Swamy Thirukovela Narasimha 
Published: March 2023

AbstractThe synthesis of some new quinoline‐thiazolidine‐2,4‐dione coupled pyrazoles (7 a–7 n) via Knoevengal condensation, N‐alkynylation and tandem one‐pot Sonogashira coupling‐cyclocondensation paths was described. All the compounds were further evaluated for their in vitro anti‐breast cancer activity against MDA‐MB‐231 and MCF‐7 and results were compared with standard drug erlotinib. Most of analogues were potent against MCF‐7 than the MDA‐MB‐231. In specific, compounds (Z)‐3‐((3‐(4‐methoxyphenyl)‐1H‐pyrazol‐5‐yl)methyl)‐5‐(quinolin‐4‐ylmethylene) thiazolidine‐2,4‐dione (7 d) and (Z)‐5‐(5‐((2,4‐dioxo‐5‐(quinolin‐4‐ylmethylene)thiazolidin‐3‐yl)methyl)‐1H‐pyrazol‐3‐yl)isophthalonitrile (7 m) had superior potency against MCF‐7 and MDA‐MB‐231 with IC50 (μg/mL) values ranging from 2.13 to 6.07. Besides, compounds (Z)‐3‐((3‐(3,5‐dimethoxyphenyl)‐1H‐pyrazol‐5‐yl)methyl)‐5‐(quinolin‐4ylmethylene)thiazolidine‐2,4‐dione (7 e), (Z)‐3‐((3‐(4‐chlorophenyl)‐1H‐pyrazol‐5‐yl)methyl)‐5‐(quinolin‐4‐ylmethylene)thiazolidine‐2,4‐dione (7 h), (Z)‐4‐(5‐((2,4‐dioxo‐5‐(quinolin‐4‐ylmethylene)thiazolidin‐3‐yl)methyl)‐1H‐pyrazol‐3‐yl)benzonitrile (7 i) and (Z)‐3‐((3‐(4‐nitrophenyl)‐1H‐pyrazol‐5‐yl)methyl)‐5‐(quinolin‐4‐ylmethylene)thiazolidine‐2,4‐dione (7 j) showed most promising potency against MCF‐7 with IC50 values 5.97‐6.43 μg/mL. The ability of compounds 7 d, 7 e, 7 h, 7 i, 7 j and 7 m to inhibit EGFR tyrosine kinase was also studied and found that compounds 7 d and 7 m showed remarkable potency as compared to erlotinib with inhibition 87.6 % and 91.4 % respectively. Molecular docking studies were then carried out for most potent compounds 7 d, 7 i, and 7 m and erlotinib on EGFR, and these compounds had encouraging binding energies and inhibition constants in comparison to erlotinib. Finally, compounds 7 d, 7 i and 7 m have high intestinal absorption with Caco‐2 permeability and followed Lipinski rules without any deviation.
Evaluation of DFT+U and HSE Frameworks for Strongly Correlated Iron Oxide
Authors: Rong Huawei , Jia Yubo , Liu Wei Wei , Kumari Cheepurupalli Kusma , English Niall J. , Zhang Xuefeng , Bandaru Sateesh , Zhao Lizhong 
Published: March 2023

AbstractFor strongly correlated metal oxides, several density functional theories have been used to describe the electronic structure of bulk iron oxide (α‐Fe2O3) and corresponding surfaces, including GGA+U and hybrid functionals (HSE), but the accuracy of these methods is unclear for these metal oxides. In the present study, first‐principles simulations were carried out to examine the effects of a hybrid density functional on α‐Fe2O3 bulk and surface slabs. Further, by using GGA+U, van der Waals corrections and O2 over binding corrections were also examined. It has been found that HSE functionals with 17.5 % Fock exchange predict better properties than those with 12 % or 25 % exchange. Methodological studies indicate that GGA+U predicted zero‐bandgap surface slabs become semiconducting slabs at HSE, and that calculated bandgaps are dependent on the actual exchange addition percentage. Our studies also show that the surface energy and relative stability of different Fe2O3 terminations are less sensitive to the inclusion of dispersion terms. However, when accounting for the GGA‐error in O2 over‐binding, significant changes occur in the computed surface energies. Additionally, HSE06 functional was tested on MnO2(0001) and MnO2(110) surfaces. Both surfaces were identified as metallic by a PBE+U calculation, and an HSE06 analysis revealed a nonzero band gap.
A New Strategy in the Synthesis of Amide‐bearing Pyrrolizine from 2‐Pyroglutamic acid
Authors: Siddaraj Ranjith , Ningegowda Raghu , Swamy Shivananju Nanjunda , Chandrashekharappa Sandeep , Priya Babu S 
Published: March 2023

AbstractThe present synthetic methodology is related to the synthesis of novel azabicycloalkanes and their synthetic analogues. New and convenient synthetic routes were developed for access to the novel Pyrrolizine, and its analogue was synthesized using a multi‐step synthesis methodology. A novel efficient synthesis of the azabicyclic ring system via Michael addition followed by the intramolecular ring closing method of pyrrolizine has been developed utilizing deprotection of the CBz group by hydrogenation followed by in‐situ Michael addition and intramolecular cyclization reaction as the key step. This methodology can be further taken forward to the pharmaceutically active natural products containing azabicyclic ring systems. All the synthesized compounds were characterized by spectroscopic methods like IH‐NMR, 13C‐NMR, LC‐MS, IR, and elemental analysis.
Physical and Chemical Interactions of the Polar and Nonpolar Solvents on the Mesoporous Silica Material to Developing Solvent Sensors.
Authors: Panecatl‐Bernal Yesmin , Alvarado Joaquín , Ortiz‐Medina Josué , Fuentecilla‐Carcamo Iván , Lima‐Juárez Rodolfo , Granada‐Ramírez Daladier‐Alonso , Chávez‐Portillo Melissa , Esquina‐Arenas Lucero , Hernández‐Corona Sergio , Alpes de Vasconcelos Elder , Mendes de Azevedo Walter , Méndez‐Rojas Miguel‐Ángel , Palomino‐Ovando Martha‐Alicia , Navarro‐Morales Esperanza 
Published: March 2023

AbstractThis work examines the physical and chemical interactions between the polar and nonpolar solvents and the surface of the MCM‐41 material, which serves as the isolating layer, employing sensing capacitance‐voltage measurements with a Metal‐Insulator‐Semiconductor (MIS) capacitor. It was observed that the MCM‐41 surface is more sensitive to methanol, which is a protic solvent, than to other nonpolar solvents like chloroform, according to the data. Furthermore, by analyzing the interaction of the methanol with the surface of MCM‐41 as a function of the applied field, the electron transfer, and the orientation of the solvent molecule, DFT Calculations using the Siesta simulation software enable us to assess this sensitivity. Based on the performance of MCM‐41 as the insulator in the MIS capacitor, MCM‐41 has a strong potential for the creation of high‐sensitivity sensors for solvent detection avoiding the functionalization process.