bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing risk prediction models aimed at predicting hospitalizations for adverse drug events in community dwelling older adults: a protocol paper
Authors: Keller Michelle S. , Qureshi Nabeel , Albertson Elaine , Pevnick Joshua , Brandt Nicole , Bui Alex , Sarkisian Catherine A. 
Published: January 2023

Abstract
Background
The objective of this paper is to describe the creation, validation, and comparison of two risk prediction modeling approaches for community-dwelling older adults to identify individuals at highest risk for adverse drug event-related hospitalizations. One approach will use traditional statistical methods, the second will use a machine learning approach.
Methods
We will construct medication, clinical, health care utilization, and other variables known to be associated with adverse drug event-related hospitalizations. To create the cohort, we will include older adults (≥ 65 years of age) empaneled to a primary care physician within the Cedars-Sinai Health System primary care clinics with polypharmacy (≥ 5 medications) or at least 1 medication commonly implicated in ADEs (certain oral hypoglycemics, anti-coagulants, anti-platelets, and insulins). We will use a Fine-Gray Cox proportional hazards model for one risk modeling approach and DataRobot, a data science and analytics platform, to run and compare several widely used supervised machine learning algorithms, including Random Forest, Support Vector Machine, Extreme Gradient Boosting (XGBoost), Decision Tree, Naïve Bayes, and K-Nearest Neighbors. We will use a variety of metrics to compare model performance and to assess the risk of algorithmic bias.
Discussion
In conclusion, we hope to develop a pragmatic model that can be implemented in the primary care setting to risk stratify older adults to further optimize medication management.
TGFBR1*6A and breast tumor fibrosis
Authors: Pasche Boris , Agyemang Kojo , Barker Grayson , Johansen Allan , Sheffield Kimberly , Li Wencheng , Grippo Paul , Kaklamani Virginia , Watabe Kounosuke , Cristofano Antonio Di 
Published: January 2023

Abstract
Dense fibrosis of the breast as assessed by mammography may be associated with early disease diagnosis. Radiation-induced fibrosis occurs in a large fraction of patients following breast conserving therapy and may be modified by genetic susceptibility. TGFBR1*6A is a high frequency, low penetrance TGFBR1 hypomorphic variant, which is associated with breast cancer risk. Here we show an association of TGFBR1*6A with breast cancer tissue fibrosis in mice and in patients with HER2-positive breast cancer.
Preoperative versus postoperative rectus sheath block for acute postoperative pain relief: a retrospective cohort study
Authors: Nakazawa Mayuko , Fukushima Toko , Shoji Kazuhiro , Momosaki Ryo , Mio Yasushi 
Published: January 2023

Abstract
Background
Although rectus sheath block (RSB) is routinely used in laparoscopic surgeries to reduce mid-abdominal pain, it is unclear whether RSB should be performed before or after surgery. In this study, we investigated the optimal timing for RSB in patients undergoing laparoscopic surgery.
Methods
This retrospective cohort study analyzed patients who underwent RSB during laparoscopic procedures at our hospital between January 2013 and December 2018. The primary outcome was the first analgesia request within 24 h after the end of anesthesia. The patients were divided into preoperative RSB (pre-RSB) and postoperative RSB (post-RSB) groups. A multivariable Cox proportional hazards regression model was used to analyze analgesia requests in the unmatched and propensity-score (PS)-matched patient populations.
Results
We analyzed the findings for 609 of 14284 patients (pre-RSB group, 227 patients; post-RSB group, 382 patients). After PS matching, 97 patients were assigned to both groups. Although the time from extubation to the first analgesic request was not significantly different between the two groups (322 versus 294 min, P = 0.57), the patients in the pre-RSB group showed a lower risk of postoperative first analgesic administration after PS matching (adjusted hazard ratio, 0.71; 95% confidence interval, 0.53–0.95; P = 0.023).
Conclusions
Among patients undergoing laparoscopic surgery, the pre-RSB group tended to show a longer time to the first analgesic request. Patients in the pre-RSB group showed a lower risk of analgesic administration within 24 h than those in the post-RSB group. Thus, it may be preferable to perform RSB preoperatively.
Trial registration:
This study was registered with the University Hospital Medical Information Network-Individual Case Data Repository (UMIN000047494).
High-density lipoprotein 2b combined with Sequential Organ Failure Assessment score as a novel prognostic indicator for patients with sepsis
Authors: Chen Yuting , Jiang Yichun , Xia Andi , Huang Zewei , Liu Zhenmi , Hong Chengying , Lin Yaowang , Liu Xueyan 
Published: January 2023

Abstract
Background
Sepsis is a serious disease and patients have high risk of short-term mortality. Despite extensive research, there are no simple and reliable tools for predicting outcomes.
Purpose
To assess the value of the combined use of high-density lipoprotein 2b (HDL2b) level and Sequential Organ Failure Assessment (SOFA) score in predicting short-term mortality from sepsis.
Materials and Methods
Forty-seven sepsis patients and 11 non-septic controls who were admitted to an intensive care unit (ICU) from January 2020 to December 2021 were examined. HDL2b as a percentage of total HDL-C and SOFA score were recorded on the first day after admission. The primary endpoint was 28-day mortality and the secondary outcome was total in-hospital mortality.
Results
Compared to non-septic controls, septic patients had a lower HDL2b level (10.95% [8.95, 12.96] vs. 23.78% [14.53, 29.16], p < 0.001). Among sepsis patients, the HDL2b level was lower in non-survivors than survivors (6.74% [4.63, 8.08] vs. 11.78 [7.20, 13.40], p = 0.002]. The areas under the receiver operating characteristic curves for predicting 28-day mortality were 0.755 for HDL2b, 0.782 for SOFA, and 0.806 for HDL2b + SOFA. Multivariate analyses indicated that HDL2b (adjusted odds ratio [aOR]: 0.780 [0.621, 0.978]), SOFA (aOR: 1.299 [0.927, 1.820]), and HDL2b + SOFA (aOR: 8.958 (1.037, 85.199]) were significant predictors of 28-day mortality. Patients with higher HDL2b + SOFA scores had higher rates of 28-day and overall in-hospital mortality.
Conclusions
Sepsis patients have reduced levels of HDL2b. HDL2b + SOFA score was a reliable predictor of 28-day and overall in-hospital mortality in sepsis patients.
Apatinib in recurrent or metastatic head and neck cancer patients
Authors: WU Qiuji , LIU Jia , LI Shaojie , WANG Juan , Zhong Yahua 
Published: January 2023

Abstract

BackgroundApatinib is a small tyrosine kinase inhibitor targeting the vascular endogenous growth receptor 2 (VEGFR-2) that shows potent anti-tumor activities in various advanced cancers via the inhibition of neo-angiogenesis. The effect of apatinib in recurrent or metastatic head and neck cancers is not fully demonstrated.MethodsPatients with recurrent or metastatic head and neck cancers consecutively treated in our institute by apatinib from January 2015 to June 2022 were enrolled. Daily 250 mg or 500 mg apatinib was given with or without chemotherapy according to patients' tolerance. Disease response, treatment-related side effects and patient survival were analyzed. Kaplan-Meier analysis was used to estimate patients' overall survival. The R software (version 4.1.3) were used for statistical analysis.ResultsA total of 85 patients (median [range] age, 53 [23-79] years; 68 male [80.0%]) were included for analysis. The median follow-up time was 30.4 (95% CI: 23.95- 40.70) months. By the end of the last follow-up, 43 (50.6%) patients died of disease progression. The median OS was 29.6 (95% CI: 12.39- 46.75) months, and the median PFS was 10.4 (95% CI: 6.11- 14.63) months. The ORR was 21.2%, and the DCR was 70.6%. The side effects were manageable and no treatment-associated death occurred. Multivariate analysis showed that OS was significantly associated with cancer pathology (squamous cell carcinoma vs. adenoid cystic carcinoma, HR=6.42, 95%CI:1.50-27.39, p = 0.0121; other types (adenocarcinoma, sarcoma, melanoma) vs. adenoid cystic carcinoma, HR=3.58, 95%CI:1.02-12.52, p = 0.0459).ConclusionApatinib showed promising anti-tumor activities in recurrent or metastatic head and neck cancers. The side effects were manageable. The effect of apatinib in recurrent or metastatic head and neck cancers warrants further verifications in larger-scale randomized studies.
Efficacy and Safety of Early Versus Delayed Reconstruction for Anterior Cruciate Ligament Injuries: A Systematic Review and Meta-analysis
Authors: Guo Tian-Ci , Feng Hui-Chuan , Yu Wei-Jie , Chen Ji-Xin , Zhai Jing-Bo , Liu Ai-Feng 
Published: January 2023

Abstract
Background: The selection of early and delayed anterior cruciate ligament reconstruction (ACLR) remains a controversial issue in the management of anterior cruciate ligament (ACL) injuries. The purpose of this study was to critically evaluate the efficacy and safety of early versus delayed ACLR for ACL injuries based on the different cut-off values of the timing of operation.
Methods:PubMed, Medline, Embase, Cochrane library, China National Knowledge Infrastructure, Chinese Biomedical Literature, and Wanfang Digital Periodical database were searched from inception to October 2022 without language restrictions. Randomized controlled trials (RCTs) and cohort studies (CSs) comparing early ACLR and delayed ACLR for ACL injuries were included.
Results:Twenty-four studies (10 RCTs and 14 CSs) were included. According to the information from included studies, 3 weeks, 4 weeks, 6 weeks, 6 months, and 12 months after ACL injuries were considered as the cut-off values of early and delayed ACLR respectively. The results of CSs showed that early ACLR performed within 4 weeks or 12 months after ACL injuries could significantly improve the Lysholm score and VAS score at 6 and 12 months postoperatively and decrease the incidence of adverse events compared with delayed ACLR (P < 0.05). Our meta-analysis involving RCTs or CSs showed that early ACLR performed within 3 weeks, 4 weeks, 6 weeks, 6 months or 12 months after ACL injuries could significantly increase the IKDC score at 6 and 12 months postoperatively compared with delayed ACLR (P < 0.05). However, no statistically significant difference in the positive rate of Lachman test and incidence of meniscus injuries and chondral lesions between two groups when 3 weeks, 6 weeks, 6 months or 12 months after ACL injuries were considered as the cut-off values of early and delayed ACLR (P > 0.05).
Conclusion: The present study suggests that early ACLR performed within 4 weeks after ACL injuries may be more effective for improving the knee function and relieving the pain compared to delayed ACLR. More high-quality studies are still warranted.
Parasitic efficiency of Encarsia guadeloupae (Hymenoptera: Aphelinidae) on symbiotic and antibiotic treated invasive whitefly, Aleurodicus rugioperculatus (Hemiptera: Aleyrodidae)
Authors: Mooranayakkar Saranya , Samuel Kennedy John , Subramanian Jeyarani 
Published: January 2023

Abstract
Rugose spiraling whitefly, Aleurodicus rugioperculatus Martin (Hemiptera: Aleyrodidae) is an invasive pest on coconut and other horticultural crops found in India during July 2016. A nymphal parasitoid, Encarsia guadeloupae Viggiani (Hymenoptera: Aphelinidae) is a potential natural enemy of A. rugioperculatus. Insect-associated bacteria with whiteflies are reported to influence the efficacy of parasitoids. Hence, the present study investigated the parasitization efficiency and biological parameters of E. guadeloupae on symbiotic (untreated) and antibiotic-treated A. rugioperculatus nymphal stages reared on four host plants viz., coconut, banana, sapota, and guava. The molecular identification of E. guadeloupae and A. rugioperculatus were confirmed using the mtCOI gene. Combination of Carbenicillin 100 µg ml− 1 + Ciprofloxacin 5 µg ml− 1 antibiotics was provided to the A. rugioperculatus by direct feeding in a parafilm feeding chamber method and the resultant populations (cultivable bacteria eliminated) were subjected to parasitoid efficiency experiments for F4, F5, and F6 generations of A. rugioperculatus. Higher parasitism (74.70%), lower emergence rate (59.70%), and longer developmental time (21.00 days) of E. guadeloupae were observed in the antibiotic-treated population than in untreated A. rugioperculatus population of the F6 generation. Elimination of insect associated bacteria through antibiotics might have reduced the nutritional status of the whiteflies and led to more susceptibility towards parasitoid attack and poor parasitoid emergence and longer developmental time in the initial generations (F4) and the parasitoid coevolve to counteract the effect with the generational exposure.
The Working Alliance Inventory - Short Revised: Psychometric properties of the youth and therapist form in youth mental health and addiction care
Authors: Benthem Patty van , Lans Rikkert M. van der , Lamers Audri , Blanken Peter , Spijkerman Renske , Vermeiren Robert R.J.M. , Hendriks Vincent M. 
Published: January 2023

AbstractThe therapeutic alliance is considered to play an important role in youth treatment. The commonly used versions of the Working Alliance Inventory (WAI) are based on Bordin’s three-dimensional alliance model. However, previous psychometric studies of the WAI did not find this three-dimensional structure in youth psychotherapy. These earlier findings may indicate different perceptions of the alliance by adolescent versus adult patients, but may also be due to methodological shortcomings. The current study aims to address previous study limitations by evaluating the factor structure of the most recent and refined version of the WAI in youth treatment and using multilevel analysis to address the hierarchical structure of the alliance data. We examined the psychometric properties of the youth (n = 203) and therapist (n = 62) versions of the short revised WAI in youth mental health and addiction care and tested the three multilevel models of alliance at start of treatment and 2-month follow-up. Our results suggests a two-factor model for youth and a three-dimensional model for their therapist at both time points. Since this is the first study that finds a best fit for a two-dimensional construct of alliance in youth, more research is needed to rule out whether the differences in alliance dimensions are due to measurement differences between the WAI-SR for youth and therapists or whether youth and their therapists truly differ in their perceptions of the concept of alliance.
Anodal Cerebellar t-DCS Impacts Skill Learning and Transfer on a Robotic Surgery Training Task
Authors: Caccianiga Guido , Mooney Ronan A. , Celnik Pablo A. , Cantarero Gabriela L. , Brown Jeremy D. 
Published: January 2023

Abstract
The cerebellum has demonstrated a critical role during adaptation in motor learning. However, the extent to which it can contribute to the skill acquisition of complex real-world tasks remains unclear. One particularly challenging application in terms of motor activities is robotic surgery, which requires surgeons to complete complex multidimensional visuomotor tasks through a remotely operated robot. Given the need for high skill proficiency and the lack of haptic feedback, there is a pressing need for understanding and improving skill development. We investigated the effect of cerebellar transcranial direct current stimulation applied during the execution of a robotic surgery training task. Study participants received either real or sham stimulation while performing a needle driving task in a virtual (simulated) and a real-world (actual surgical robot) setting. We found that cerebellar stimulation significantly improved performance compared to sham stimulation at fast (more demanding) execution speeds in both virtual and real-world training settings. Furthermore, participants that received cerebellar stimulation more effectively transferred the skills they acquired during virtual training to the real world. Our findings underline the potential of non-invasive brain stimulation to enhance skill learning and transfer in real-world relevant tasks and, more broadly, its potential for improving complex motor learning.
Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation model without segment filamentous bacteria
Authors: Iwamoto Kazuya , Bundo Miki , Murata Yui , Imamura Yuko , Nakachi Yutaka , Fujii Shinya , Kato Tadafumi , Kubota-Sakashita Mie 
Published: January 2023

Abstract
Maternal immune activation is one of the major environmental risk factors for offspring to develop psychiatric disorders. A synthetic viral mimetic immunogen, polyinosinic-polycytidylic acid (poly(I:C)), has often been used to induce maternal immune activation in animal models of psychiatric disorders. In the mouse poly(I:C) model, the existence of segment filamentous bacteria (SFB) in the maternal intestine has been reported to be important for the induction of ASD-related behavioral alterations as well as atypical cortical development called cortical patches. This study aimed to elucidate the effect of poly(I:C) in the absence of intestinal SFB, which was maintained by vancomycin drinking. The poly(I:C) was administered at various time points between embryonic Day 9 to 16. In this condition, cortical patches were not observed at postnatal Day 0 or 1. The conspicuous PPI deficit of male adult offspring was observed in a poly(I:C) time-dependent manner, whereas the effect on females appeared less clear. On the other hand, a notable deficit in social interaction was observed in female mice, whereas males were less affected. This study revealed sex-dependent behavioral alterations in the mouse poly(I:C) model in the SFB-negative condition.
Explicit multi-slit Loewner flows and their geometry
Authors: Theodosiadis Eleftherios 
Published: January 2023

Abstract
In this paper we present explicit solutions to the radial and chordal Loewner PDE and we make an extensive study of their geometry. Specifically, we study multi-slit Loewner flows, driven by the time-dependent point masses $\mu_{t}:=\sum_{j=1}^{n}b_j \delta_{\{\zeta_j e^{iat}\}}$ in the radial case and $\nu_t:=\sum_{j=1}^{n}b_j\delta_{\{k_j\sqrt{1-t}\}}$ in the chordal case, where all the above parameters are chosen arbitrarily.
Furthermore, we investigate their close connection to the semigroup theory of holomorphic functions, which also allows us to map the chordal case to the radial one.
Prediction of water-level variations using a combined time series-geostatistical model in an aquifer surrounded by karstic formation: A case study from the semi-arid Hamadan province, Iran
Authors: Tizro A. Taheri , Fryar Alan E. , Voudouris K. S. , Talebi M. , fasihi rojin 
Published: January 2023

Abstract
Understanding groundwater responses to recharge is particularly important in alluvial aquifers which are surrounded by karstic formations in semi-arid and arid regions, such as the high Zagros region of western Iran. Evaluation of input and output time series provides comprehensive information on the hydrodynamic behavior of these aquifers. Time-series models were used to predict water levels using 20 years of monthly data (1997–2017) from 29 observation wells in the Nahavand Plain aquifer. Water levels were interpolated using conventional kriging and inverse-distance weighting and show consistent trends. Water-level change maps were prepared for annual intervals from 2012 to 2019 and for the period 2018–2022. Most of the area shows a trend of rising water levels, which appears to reflect recharge through karstic formations in the area.
Theoretical studies on Copper(II) complexes based on different carboxylate ligands: Hirshfeld surface analysis and molecular docking studies
Authors: Akhtar Muhammad Nadeem , Bilal Muhammad Safdar , Ali Arfan , Waseem Shazia , shahzad Muhammad Nadeem , Ibragimov Aziz B. , Rehman Aziz ur , Ahmad Muhammad Shahwaz , Shahid M. 
Published: January 2023

Abstract
Hirshfeld surface analysis and molecular docking study were carried out on a series of copper complexes formulated; [CuII2(C6H5COO)4(C6H5COOH)2], C6H5COOH = benzoic acid (1), [Cu(ppa)2(H2O)2]n, ppa = 3-Pyridinepropionic acid (2) and [Cu(N3)(C6H5COO)(MeOH)]n (3).
Hirshfeld surface investigation is explored for analysing molecular attractions and indicating all of the supramolecular communications of the crystal arrangement. The 2D graphs of 1 and 2 are identical, indicating the H∙∙∙H, O∙∙∙H/H∙∙∙O and C∙∙∙H/H∙∙∙C are the major participation of the crystal pattern of arrangement of these molecules, with the H∙∙∙H and O∙∙∙H/H∙∙∙O attachments contributing with 42.4 %, 41.6 % and 9.9 %, 8.9 % for 1 and 2 respectively. In 3, the 2D plot is decayed to show H∙∙∙H (33%), N∙∙∙H (13.5%) and O∙∙∙H/H∙∙∙O (5.9%), interactions specific region while C∙∙∙H/H∙∙∙C has 13 % of intermolecular interactions. Molecular docking studies in 1-3 indicates about the minimum relative interaction energies in these complexes are -6.2, -7.8 and -7.6 kcal/mol and these negative values suggest greater binding potentials of the complexes to DNA.
Corneal Endothelial cell changes after sub scleral Trabeculectomy in glaucoma patients
Authors: Hassan Hamida A. k. , Shalaby Sawsan Abdel Sabour , Mahmoud Doaa Aly 
Published: January 2023

Abstract
Background: About 1% of the population over the age of 40 develops glaucoma, making it the most common cause of irreversible blindness. Seventy-four per cent of all glaucoma cases are primary open-angle glaucoma. Trabeculectomy is a form of modern filtration surgery used to lower intraocular pressure in a glaucoma patient.
Aim of the Work: evaluation of corneal endothelial cells changes before and after sub scleral trabeculectomy using specular microscopy.
Patients and Methods: Our study was a prospective non-randomized study of 20 glaucomatous patients managed by trabeculectomy with Mitomycin C, the study included patients above the age of 40 years with open angle glaucoma that failed to be controlled by medical treatment. We compared the preoperative and postoperative central corneal endothelial cell density (ECD), endothelial cell coefficient of variation (CV), Hexagonal cell percentage, corneal thickness, best-corrected visual acuity, and intraocular pressure (IOP).
Results: our study revealed a highly significant decrease in central corneal endothelial cell count following trabeculectomy, the suggested mechanisms may be the toxic effect of MMC, increased manipulation in the anterior chamber during surgery and fluctuation of IOP following surgery
Conclusion: According to our findings, the central corneal thickness hardly budges after trabeculectomy, and the fraction of hexagonal cells decreases.
Tachyonic AdS/QCD, Determining the Strong Running Coupling and β-function in both UV and IR Regions of AdS Space
Authors: Issifu Adamu , Abbey Elijah A. , Brito Francisco A. 
Published: January 2023

Abstract
In this paper, we investigate QCD-like running coupling αsAdS (Q2) and its associated β-function β(Q2) in the spirit of tachyonic AdS/QCD. We distort the bulk AdS5 space using color dielectric function G(ϕ(z)) associated with tachyons, with ϕ(z) the tachyon field. The function presents different properties of αsAdS (Q2) at small and large values of the fifth-dimensional holographic variable z. The function distorts the AdS space, giving αsAdS (Q2) and its β-function β(Q2) at any Q2 scale, with Q2 the space-like momentum. The result obtained for a large value of z is expected to show characteristics similar to nonperturbative QCD. On the other hand, the result obtained for a small value of z is expected to show characteristics similar to perturbative QCQ. The presence of free tachyons leads to distortion of the AdS space at a small z, that notwithstanding, condensed tachyon states also lead to large z distortion. This provides a unified background for determining αsAdS (Q2) and its β(Q2) in both the ultraviolet (UV) and infrared (IR) regions using a single function in the framework of tachyonic AdS/QCD.