bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting citations in Dutch case law with natural language processing
Authors: Schepers Iris , Medvedeva Masha , Bruijn Michelle , Wieling Martijn , Vols Michel 
Published: June 2023

AbstractWith the ever-growing accessibility of case law online, it has become challenging to manually identify case law relevant to one’s legal issue. In the Netherlands, the planned increase in the online publication of case law is expected to exacerbate this challenge. In this paper, we tried to predict whether court decisions are cited by other courts or not after being published, thus in a way distinguishing between more and less authoritative cases. This type of system may be used to process the large amounts of available data by filtering out large quantities of non-authoritative decisions, thus helping legal practitioners and scholars to find relevant decisions more easily, and drastically reducing the time spent on preparation and analysis. For the Dutch Supreme Court, the match between our prediction and the actual data was relatively strong (with a Matthews Correlation Coefficient of 0.60). Our results were less successful for the Council of State and the district courts (MCC scores of 0.26 and 0.17, relatively). We also attempted to identify the most informative characteristics of a decision. We found that a completely explainable model, consisting only of handcrafted metadata features, performs almost as well as a less well-explainable system based on all text of the decision.
Evaluation of a potential umbrella species using favourability models: the case of the endangered little bustard (Tetrax tetrax) and steppe birds
Authors: Morales Manuel B. , Merencio Ángela , de la Morena Eladio L. García 
Published: June 2023

AbstractFarmland biodiversity is in alarming decline worldwide due to agriculture intensification. In this context, the umbrella species concept may help in better targeting conservation efforts, focusing on species whose requirements may best cover those of other components of biological communities. We test this idea using the little bustard (Tetrax tetrax), a strongly declining steppe bird depending on extensive agricultural landscapes of south-western Europe, to explore the degree to which its habitat requirements can predict those of other sympatric endangered steppe birds. We use little bustard and other nine species distribution data at 10 × 10 km scale in Castilla-La Mancha (the most important region for the little bustard in Spain and the EU) and habitat favourability models to identify variables explaining little bustard favourability that can robustly predict habitat favourability also for the other nine species. Models fitted with variables explaining little bustard favourability and applied on co-occurring species yielded varying performance results. Models support the role of the little bustard as umbrella species only for a part of the steppe bird community, and more precisely, for species linked to cereal and grassland-dominated landscapes, but not for landscape generalist species, distributed over mosaic landscapes including shrublands and woody crops. Results also highlight the importance of favourable extensive cereal steppes for the conservation of strongly endangered species (little and great bustard, Montagu’s harrier, pin-tailed sandgrouse, calandra lark), some of which are largely understudied (pin-tailed sandgrouse and calandra lark), despite their marginal coverage by the Natura 2000 protected area network.
Characterization of plaque phenotypes exhibiting an elevated pericoronary adipose tissue attenuation: insights from the REASSURE-NIRS registry
Authors: Kitahara Satoshi , Kataoka Yu , Miura Hiroyuki , Nishii Tatsuya , Nishimura Kunihiro , Murai Kota , Iwai Takamasa , Matama Hideo , Honda Satoshi , Fujino Masashi , Yoneda Shuichi , Takagi Kensuke , Otsuka Fumiyuki , Asaumi Yasuhide , Fujino Yusuke , Tsujita Kenichi , Puri Rishi , Nicholls Stephen J. , Noguchi Teruo 
Published: June 2023

AbstractInflammation has been considered to promote atheroma instability. Coronary computed tomography angiography (CCTA) visualizes pericoronary adipose tissue (PCAT) attenuation, which reflects coronary artery inflammation. While PCAT attenuation has been reported to predict future coronary events, plaque phenotypes exhibiting high PCAT attenuation remains to be fully elucidated. The current study aims to characterize coronary atheroma with a greater vascular inflammation. We retrospectively analyzed culprit lesions in 69 CAD patients receiving PCI from the REASSURE-NIRS registry (NCT04864171). Culprit lesions were evaluated by both CCTA and near-infrared spectroscopy/intravascular ultrasound (NIRS/IVUS) imaging prior to PCI. PCAT attenuation at proximal RCA (PCATRCA) and NIRS/IVUS-derived plaque measures were compared in patients with PCATRCA attenuation ≥ and < -78.3 HU (median). Lesions with PCATRCA attenuation ≥ -78.3 HU exhibited a greater frequency of maxLCBI4mm ≥ 400 (66% vs. 26%, p < 0.01), plaque burden ≥ 70% (94% vs. 74%, p = 0.02) and spotty calcification (49% vs. 6%, p < 0.01). Whereas positive remodeling (63% vs. 41%, p = 0.07) did not differ between two groups. On multivariable analysis, maxLCBI4mm ≥ 400 (OR = 4.07; 95%CI 1.12–14.74, p = 0.03), plaque burden ≥ 70% (OR = 7.87; 95%CI 1.01–61.26, p = 0.04), and spotty calcification (OR = 14.33; 95%CI 2.37–86.73, p < 0.01) independently predicted high PCATRCA attenuation. Of note, while the presence of only one plaque feature did not necessarily elevate PCATRCA attenuation (p = 0.22), lesions harboring two or more features were significantly associated with higher PCATRCA attenuation. More vulnerable plaque phenotypes were observed in patients with high PCATRCA attenuation. Our findings suggest PCATRCA attenuation as the presence of profound disease substrate, which potentially benefits from anti-inflammatory agents.
Does Caring for Parents Take Its Toll? Gender Differences in Caregiving Intensity, Coresidence, and Psychological Well-Being Across Europe
Authors: Labbas Elisa , Stanfors Maria 
Published: June 2023

AbstractGiven population ageing and the emphasis on in-home care, more working-age adults are facing the demands of providing unpaid care to the elderly with potential implications for their own well-being. Such effects likely vary across Europe because care is differently organized with a differing emphasis on public support, dependence on family, and orientation toward gender equality. We studied the relationship between unpaid caregiving for elderly parents and the psychological well-being of older working-age (50–64) men and women by analysing data from the Survey of Health, Retirement, and Ageing in Europe (SHARE), covering 18 countries between 2004 and 2020 (N = 24,338), using ordinary least squares (OLS). We examined risk of depression by caregiving intensity and tested whether coresidence mediated outcomes. Men and women providing care to parents experience important psychological well-being losses across Europe, especially when caregiving is intensive. A heavier caregiving burden associated with coresidence explains a regime gradient in depression, not least for women in Southern Europe. Results highlight the spillover costs of unpaid caregiving across Europe and the need to address caregiver psychological well-being, especially in contexts where state support for elder care is low and coresidence is common.
Self-guided digital acceptance and commitment therapy for fibromyalgia management: results of a randomized, active-controlled, phase II pilot clinical trial
Authors: Catella Stephanie , Gendreau R. Michael , Kraus Allison C. , Vega Nicolette , Rosenbluth Michael J. , Soefje Sherry , Malhotra Shishuka , Luciano Juan V. , McCracken Lance M. , Williams David A. , Arnold Lesley M. 
Published: June 2023

AbstractAlthough empirically validated for fibromyalgia (FM), cognitive and behavioral therapies, including Acceptance and Commitment Therapy (ACT), are inaccessible to many patients. A self-guided, smartphone-based ACT program would significantly improve accessibility. The SMART-FM study assessed the feasibility of conducting a predominantly virtual clinical trial in an FM population in addition to evaluating preliminary evidence for the safety and efficacy of a digital ACT program for FM (FM-ACT). Sixty-seven patients with FM were randomized to 12 weeks of FM-ACT (n = 39) or digital symptom tracking (FM-ST; n = 28). The study population was 98.5% female, with an average age of 53 years and an average baseline FM symptom severity score of 8 out of 11. Endpoints included the Fibromyalgia Impact Questionnaire-Revised (FIQ-R) and the Patient Global Impression of Change (PGIC). The between-arm effect size for the change from baseline to Week 12 in FIQ-R total scores was d = 0.44 (least-squares mean difference, − 5.7; SE, 3.16; 95% CI, − 11.9 to 0.6; P = .074). At Week 12, 73.0% of FM-ACT participants reported improvement on the PGIC versus 22.2% of FM-ST participants (P < .001). FM-ACT demonstrated improved outcomes compared to FM-ST, with high engagement and low attrition in both arms. Retrospectively registered at ClinicalTrials.gov (NCT05005351) on August 13, 2021.
The Accessibility Problem for Geometric Rough Differential Equations
Authors: Boutaib Youness 
Published: June 2023

AbstractWe show how to use geometric arguments to prove that the terminal solution to a rough differential equation driven by a geometric rough path can be obtained by driving the same equation by a piecewise linear path. For this purpose, we combine some results of the seminal work of Sussmann on orbits of vector fields [1] with the rough calculus on manifolds developed by Cass, Litterer and Lyons in [2].
The Frege–Hilbert controversy in context
Authors: Rohr Tabea 
Published: June 2023

AbstractThis paper aims to show that Frege’s and Hilbert’s mutual disagreement results from different notions ofAnschauungand their relation to axioms. In the first section of the paper, evidence is provided to support that Frege and Hilbert were influenced by the same developments of 19th-century geometry, in particular the work of Gauss, Plücker, and von Staudt. The second section of the paper shows that Frege and Hilbert take different approaches to deal with the problems that the developments in 19th-century geometry posed for the traditional Kantian philosophy of mathematics. Frege maintains thatAnschauungis a source of knowledge by which we acknowledge geometrical axioms as true. For Hilbert, in contrast, axioms provide one of several correct “pictures” of reality. Hilbert’s position is thereby deeply influenced by epistemological ideas from Hertz and Helmholtz, and, in turn, influenced the neo-Kantian Cassirer.
The “Mystery Cell Population” Residing in Murine Bone Marrow – A Missing Link Between Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells?
Authors: Bujko Kamila , Suszynska Malwina , Franczak Stephanie , Kucia Magdalena , Ratajczak Mariusz Z. , Ratajczak Janina 
Published: June 2023

AbstractBone marrow (BM) contains not only hematopoietic stem cells (HSCs) but also some very rare, early development, small quiescent stem cells that, upon activation, may differentiate across germlines. These small cells, named very small embryonic like stem cells (VSELs), can undergo specification into several types of cells including HSCs. Interestingly, murine BM is also home to a “mystery” population of small CD45+ stem cells with many of the phenotypic characteristics attributed to resting HSCs. Since the size of the “mystery” population cells are between that of VSELs and HSCs, and because CD45− VSELs can be specified into CD45+ HSCs, we hypothesized that the quiescent CD45+ “mystery” population could be a missing developmental link between VSELs and HSCs. To support this hypothesis, we showed that VSELs first became enriched for HSCs after acquiring expression of the CD45 antigen already expressed on “mystery” stem cells. Moreover, VSELs freshly isolated from BM similar to the “mystery” population cells, are quiescent and do not reveal hematopoietic potential in in vitro and in vivo assays. However, we noticed that CD45+ “mystery” population cells, similar to CD45− VSELs, became specified into HSCs after co-culture over OP9 stroma. We also found that mRNA for Oct-4, a pluripotency marker that is highly expressed in VSELs, is also detectable in the “mystery” population cells, albeit at a much lower level. Finally, we determined that the “mystery” population cells specified over OP9 stroma support were able to engraft and establish hematopoietic chimerism in lethally irradiated recipients. Based on these results, we propose that the murine BM “mystery” population could be an intermediate population between BM-residing VSELs and HSCs already specified for lympho-hematopoietic lineages.
Graphical Abstract
Das Aufwachsen junger Menschen mit und ohne Behinderungen verantworten
Authors: Molnar Daniela 
Published: June 2023

ZusammenfassungDem Jugendamt kommt bei der Bearbeitung von Problemen im Kontext des Aufwachsens junger Menschen eine besondere Verantwortung zu, die sich aus seinem Verhältnis zu den Kindern und Jugendlichen als ‚Werdenden‘ speist. Vor dem Hintergrund der zukünftigen Gesamtzuständigkeit steht das Jugendamt nun vor der Herausforderung, auch alle Eingliederungshilfen für junge Menschen seiner Verantwortung entsprechend zu bearbeiten. In der derzeitigen aktenförmigen Fallbearbeitung in der Eingliederungshilfe außerhalb des Jugendamtes zeigt sich allerdings mit individualisierenden Problemzuschreibungen und einer Fokussierung auf Bedarfe von Betreuungspersonen und -institutionen eine Verantwortungsumkehr; aus diesem Befund lassen sich Implikationen für die Gestaltung der Fallbearbeitung im Modus von Inklusion ableiten.
A unique pericyclid from the Viséan of the eastern Anti-Atlas (Morocco) and other Helicocyclinae n. subfam. (Goniatitida)
Authors: Becker Ralph Thomas 
Published: June 2023

AbstractThe Jebel Begaa region of the eastern Anti-Atlas in SE Morocco yielded a single, very well-preserved goniatite that is closely related to Helicocyclus divergens Riley, 1996 from the lower Viséan (Chadian) of northern England. Both are placed in a new genus, Tectocyclus n. gen., with the Moroccan T. herbigi n. sp. as the type species. Characteristic are its subtriangular suture elements, which distinguish it strongly from Helicocyclus gracillimus Schindewolf, 1951, which is revised based on the re-examination of its types. The type-species of Helicocyclus is characterized by wide, bell-shaped lateral lobes, unlike as in described helicocyclids from the upper Tournaisian and Viséan of North Africa, Russia, and Central Asia. These are assigned, partly with reservation, to Serpenticyclus n. gen., with the oldest species, Helicocyclus fuscus Korn, Bockwinkel, Ebbighausen, and Klug, 2003, as the type-species. All three genera form the Helicocyclinae n. subfam., which first appeared in North Africa, migrated at the end of the Tournaisian across the Variscan Sea to the southern shelf of Laurussia, to Central Asia, and to the Urals seaway, where it survived into Arundian levels of the Viséan.
Improving Health and Reducing Absence Days at Work: Effects of a Mindfulness- and Skill-Based Leadership Intervention on Supervisor and Employee Sick Days
Authors: Vonderlin Ruben , Schmidt Burkhard , Biermann Miriam , Lyssenko Lisa , Heinzel-Gutenbrunner Monika , Kleindienst Nikolaus , Bohus Martin , Müller Gerhard 
Published: June 2023

Abstract
Objectives
Mindfulness-based programs (MBPs) at the workplace have attracted increasing interest due to their positive effects on health and work-related outcomes. However, it is unclear whether these effects translate into reductions in cost-related and objectively assessed outcomes, such as sick days. The aim of this study was to evaluate the effectiveness of an MBP for supervisors on reduction of sick days of both supervisors and their employees.

Method
We conducted a quasi-experimental study comparing the effects of a 3-day MBP for supervisors to a passive control cohort based on propensity score matching. Sick days for supervisors (n = 13 in the MBP group; n = 269 in the control group) and their employees (n = 196 in the MBP group; n = 1352 in the control group) were drawn directly from their health insurance records over 4 years; 2 years before (pre) and 2 years after (post) the start of the intervention. A generalized linear model was used to analyze sick days after the intervention, adjusted for pre-intervention sick days.

Results
Supervisors in the MBP condition showed significantly lower nonspecific (general) sick days (M = 13.9 days) compared to their matched controls at post-intervention (M = 32.9 days, χ2[1] = 4.38, p = 0.036, d=0.47). Sensitivity analyses showed that this effect was driven mainly by an increase in sick days in the control group. At the employee level, both specific and nonspecific sick days did not differ significantly between the MBP and control conditions.

Conclusions
Our results indicate that MBPs for supervisors at the workplace have the potential to positively affect their nonspecific sick days. Although these effects did not occur at the employee level, the data provide a first indication that MBPs offered at the workplace might be cost-effective.

Preregistration
The study was preregistered at the German Register of Clinical Studies (DRKS-ID: DRKS00013635).
A modified melanoma-molGPA scoring model: assessment of survival after and efficacy of different radiotherapy modalities in patients with melanoma brain metastases
Authors: Wu Qian , Zhang Xueqing , Li Hui , Tang Lirui , Zeng Yibin , Lin Jing , Chen Yu , Li Jinluan 
Published: June 2023

Abstract
Purpose
Patients with malignant melanoma brain metastases (MBMs) have poor prognoses. For MBMs, the Melanoma-molGPA is the most widely used predictive score, but its predictive value remains uncertain in patients fully treated with radiotherapy. We identified MBMs prognostic factors and modified the prognostic scoring model.

Methods
We retrospectively analyzed patients diagnosed with MBMs between December 2010 and November 2021 for prognostic factors influencing overall survival (OS) by univariate and multivariate analyses. Nomogram plots were based on Cox regression modeling. We evaluated overall survival (OS) using Kaplan–Meier survival curves and log-rank tests.

Results
The median OS (mOS) was 7.9 months. On multivariate analysis, BRAF mutation status (p < 0.001), number of brain metastases (BM) (p < 0.001), presence of liver metastases (p < 0.001), brain metastases with a midline shift (p = 0.003), Karnofsky Performance Score (p = 0.02), and lymphocyte-to-monocyte ratio (p < 0.0001) were independent OS predictors. These were incorporated into a modified risk-stratification model. Overall, whole-brain radiotherapy (WBRT) did not significantly affect mOS (mOS, 6.89 vs. 8.83 months; p = 0.07). After risk stratification using our model, WBRT resulted in no significant survival benefit in the low-risk group (mOS 10.07 vs. 13.1 months; p = 0.71) but significantly worse prognosis in the high-risk group (mOS, 2.37 vs. 6.92 months; p = 0.026).

Conclusion
We propose a modified model that accurately distinguishes the prognosis of patients with MBMs and guides decision-making for radiotherapy. Based on this novel model, WBRT should be cautiously selected for high-risk patients.
Serum extracellular vesicles derived hsa-miR-320d as an indicator for progression of clear cell renal cell carcinoma
Authors: Xue Yizheng , Chen Tianyi , Hou Naiqiao , Wu Xiaorong , Kong Wen , Huang Jiwei , Zhang Jin , Chen Yonghui , Zheng Junhua , Zhai Wei , Xue Wei 
Published: June 2023

Abstract
Background
Renal cell carcinoma (RCC) is a prevalent malignancy with a rising incidence in developing countries. Clear cell renal cell carcinoma (ccRCC) constitutes 70% of RCC cases and is prone to metastasis and recurrence, yet lacks a liquid biomarker for surveillance. Extracellular vesicles (EVs) have shown promise as biomarkers in various malignancies. In this study, we investigated the potential of serum EV-derived miRNAs as a biomarker for ccRCC metastasis and recurrence.

Materials and methods
Patients diagnosed with ccRCC between 2017 and 2020 were recruited in this study. In the discovery phase, high throughput small RNA sequencing was used to analyze RNA extracted from serum EVs derived from localized ccRCC (LccRCC) and advanced ccRCC (AccRCC). In the validation phase, qPCR was employed for quantitative detection of candidate biomarkers. Migration and invasion assays were performed on ccRCC cell line OSRC2.

Results
Serum EVs derived hsa-miR-320d was significantly up-regulated in patients with AccRCC than in patients with LccRCC (p < 0.01). In addition, Serum EVs derived hsa-miR-320d was also significantly up-regulated in patients who experienced recurrence or metastasis (p < 0.01). Besides, hsa-miR-320d enhances the pro-metastatic phenotype of ccRCC cells in vitro.

Conclusions
Serum EVs derived hsa-miR-320d as a liquid biomarker exhibits significant potential for identifying the recurrence or metastasis of ccRCC, as well as hsa-miR-320d promotes ccRCC cells migration and invasion.
The biological significance of cuproptosis-key gene MTF1 in pan-cancer and its inhibitory effects on ROS-mediated cell death of liver hepatocellular carcinoma
Authors: Song Liying , Zeng Rong , Yang Keda , Liu Wei , Xu Zhijie , Kang Fanhua 
Published: June 2023

AbstractMetal regulatory transcription factor 1 (MTF1) has been reported to be correlated with several human diseases, especially like cancers. Exploring the underlying mechanisms and biological functions of MTF1 could provide novel strategies for clinical diagnosis and therapy of cancers. In this study, we conducted the comprehensive analysis to evaluate the profiles of MTF1 in pan-cancer. For example, TIMER2.0, TNMplot and GEPIA2.0 were employed to analyze the expression values of MTF1 in pan-cancer. The methylation levels of MTF1 were evaluated via UALCAN and DiseaseMeth version 2.0 databases. The mutation profiles of MTF1 in pan-cancers were analyzed using cBioPortal. GEPIA2.0, Kaplan–Meier plotter and cBioPortal were also used to explore the roles of MTF1 in cancer prognosis. We found that high MTF1 expression was related to poor prognosis of liver hepatocellular carcinoma (LIHC) and brain lower grade glioma (LGG). Also, high expression level of MTF1 was associated with good prognosis of kidney renal clear cell carcinoma (KIRC), lung cancer, ovarian cancer and breast cancer. We investigated the genetic alteration and methylation levels of MTF1 between the primary tumor and normal tissues. The relationship between MTF1 expression and several immune cells was analyzed, including T cell CD8 + and dendritic cells (DC). Mechanically, MTF1-interacted molecules might participate in the regulation of metabolism-related pathways, such as peptidyl-serine phosphorylation, negative regulation of cellular amide metabolic process and peptidyl-threonine phosphorylation. Single cell sequencing indicated that MTF1 was associated with angiogenesis, DNA repair and cell invasion. In addition, in vitro experiment indicated knockdown of MTF1 resulted in the suppressed cell proliferation, increased reactive oxygen species (ROS) and promoted cell death in LIHC cells HepG2 and Huh7. Taken together, this pan-cancer analysis of MTF1 has implicated that MTF1 could play an essential role in the progression of various human cancers.