bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise and fatigue: integrating the role of K+, Na+ and Cl− in the regulation of sarcolemmal excitability of skeletal muscle
Authors: Renaud Jean-Marc , Ørtenblad Niels , McKenna Michael J. , Overgaard Kristian 
Published: August 2023

AbstractPerturbations in K+have long been considered a key factor in skeletal muscle fatigue. However, the exercise-induced changes in K+intra-to-extracellular gradient is by itself insufficiently large to be a major cause for the force decrease during fatigue unless combined to other ion gradient changes such as for Na+. Whilst several studies described K+-induced force depression at high extracellular [K+] ([K+]e), others reported that small increases in [K+]einduced potentiation during submaximal activation frequencies, a finding that has mostly been ignored. There is evidence for decreased Cl−ClC-1 channel activity at muscle activity onset, which may limit K+-induced force depression, and large increases in ClC-1 channel activity during metabolic stress that may enhance K+induced force depression. The ATP-sensitive K+channel (KATPchannel) is also activated during metabolic stress to lower sarcolemmal excitability. Taking into account all these findings, we propose a revised concept in which K+has two physiological roles: (1) K+-induced potentiation and (2) K+-induced force depression. During low-moderate intensity muscle contractions, the K+-induced force depression associated with increased [K+]eis prevented by concomitant decreased ClC-1 channel activity, allowing K+-induced potentiation of sub-maximal tetanic contractions to dominate, thereby optimizing muscle performance. When ATP demand exceeds supply, creating metabolic stress, both KATPand ClC-1 channels are activated. KATPchannels contribute to force reductions by lowering sarcolemmal generation of action potentials, whilst ClC-1 channel enhances the force-depressing effects of K+, thereby triggering fatigue. The ultimate function of these changes is to preserve the remaining ATP to prevent damaging ATP depletion.
Advance Care Planning (ACP) als Element eines klinisch-ethischen Unterstützungsangebotes – Darstellung und Evaluation
Authors: Nowak Andre , Linoh Kim Philip , Flöther Lilit , Schildmann Jan , Nadolny Stephan 
Published: August 2023

Zusammenfassung
Hintergrund
Advance Care Planning (ACP) wird auch in Deutschland zunehmend praktiziert. Aus klinisch-ethischer Perspektive bietet ACP eine Möglichkeit, Vorausverfügungen zu konkretisieren und auf diese Weise die Entscheidungsfindung bei fehlender Selbstbestimmungsfähigkeit von Patient:innen zu unterstützen. Während es für Gesprächsangebote im Sinne des ACP in Pflegeeinrichtungen und Einrichtungen der Eingliederungshilfe seit 2015 Finanzierungsmöglichkeiten gibt und erste Studien zu Angeboten veröffentlich wurden, fehlt es in Deutschland bisher an publizierten Evaluationsstudien zu ACP-Angeboten im Krankenhaus.

Intervention und Methoden
Im vorliegenden Beitrag erfolgt die strukturierte Darstellung von ACP als ein Element des klinisch-ethischen Unterstützungsangebotes am Universitätsklinikum Halle (Saale) (UKH). Es erfolgte eine quantitative Inhaltsanalyse der schriftlichen Dokumentation von durchgeführten ACP-Gesprächsprozessen für den Zeitraum der Pilotphase von 01/2020 bis 08/2021 (20 Monate).

Ergebnisse
Im Zeitraum wurden 93 ACP-Gespräche angefragt. Mit 79 Patient:innen konnten 110 Gespräche geführt werden. 46 % der Anfragen kamen von Palliative Care betreuten Patient:innen. Im Durchschnitt dauerten die Beratungen 45 min. Der Gesprächsprozess zur Erstellung einer Patientenverfügung benötigte durchschnittlich 122 min und 2,5 Gespräche. Bei 23 % der Patient:innen endete der ACP-Prozess nach dem Erstgespräch. Die Inhalte der ACP-Prozesse tangierten verschiedene Bereiche anderer Professionen im Krankenhaus, insbesondere die Entscheidungsfindung über aktuelle Diagnostik und Therapie zwischen Ärzt:innen und Patient:innen.

Diskussion
Die Einführung eines ACP-Angebotes im Krankenhaus zeigt neben einer Vielzahl an Chancen auch Herausforderungen auf, welche es im gemeinsamen Diskurs zu bewältigen gilt. Bei der Einbettung eines ACP-Angebots im Krankenhaus müssen die Besonderheiten der Klinik und insbesondere die Abgrenzung von ACP zu anderen Arbeitsfeldern der Ethikberatung, wie beispielsweise die Ethikfallberatung, bedacht werden.
Severity of spinal degeneration does not affect the pain reduction under continuous epidural analgesia
Authors: Heck Vincent J. , Himpe Bastian , Vinas-Rios Juan M. , Prasse Tobias , Pflüger Michael J. , Lenz Maximilian , Schmidt Sven , Kessler Paul , Rauschmann Michael 
Published: August 2023

Abstract
Purpose
To outline clinical effectiveness of continuous epidural analgesia (CEA) in patients with failed back surgery syndrome (FBSS) or lumbar spinal stenosis (LSS) depending on severity of spinal degeneration.

Methods
In this retrospective cohort study, all patients with FBSS or LSS who underwent CEA within an inpatient rehabilitation program were evaluated. The pain reduction was measured by VAS on an hourly basis. Substantial pain reduction was defined as a minimal clinically important difference (MCID) > 50%. Severity of spinal degeneration, side effects and patient-specific characteristics were documented.

Result
We included a total of 148 patients with 105 patients suffering from FBSS and 48 with LSS. The average pain reduction was − 37.6 ± 19.2 in FBSS and − 38.1 ± 17.8 in LSS group (p < .001 and p < .001, respectively). In the FBSS group, sensory deficits (p = .047) and numbness (p = .002), and in the LSS group, a severe disability measured by ODI (38.2 ± 15.4 vs. 57.3 ± 11.3, p < .001) significantly contributed to a worse outcome. The severity of the spinal degeneration and psychological disorders did not affect the pain reduction in terms of MCID.

Conclusions
This study provides new evidence about CEA in the treatment of FBSS and LSS. CEA provides a significant pain reduction even under intensified physiotherapeutic exercising in patients with severe spinal degeneration and a broad variety of secondary diagnoses. Neurologic deficits in case of FBSS and severe disability in case of LSS may be risk factors for less favorable outcome.
Long-term results of arthroscopic repair of type II SLAP lesions in sports: assessment of return to pre-injury playing level and critical risk factors for complication
Authors: Della Rotonda G. , Guastafierro A. , Viglione S. , Cozzolino A. , Russo F. , Polito R. , Daniele A. , Nigro E. , Ciccarelli M. , Russo R. 
Published: August 2023

Abstract
Purpose
The management of isolated SLAP lesions is still debated especially in athletes. Aims of the study were: 1. to analyse our algorithm to treat SLAP lesions starting from the selection of patients for surgery and 2. to correlate the familiarity for diabetes and hypothyroid disorders with post-operative results.

Methods
Seventy-eight patients with isolated SLAP lesion were arthroscopically treated using knotless anchors and microfractures. All patients had a pre-operative and post-operative clinical examination according to Walch–Duplay, Constant, Rowe and Dash scores and interviewed for familiarity to diabetes and hypothyroid disorders.

Results
About 68.8% of patients solved pain with rehabilitation. About 29% of patients returned to the sports activities. About 32% of patients were no responder to physiotherapy and were arthroscopically treated. About 53.9% of patients responded excellent, 34.7% good, 3.8% medium and 7.6% poor results according to Walch–Duplay score. The Constant score increased from 64 to 95, the Rowe score from 48 to 96. The outcomes were significantly worse in patients with familiarity for diabetes.

Conclusions
Microfractures and knotless anchor give long-term good results for the treatment of SLAP lesions in athletes. The familiarity for diabetes is an important risk factor that can lead to decreased outcomes.
Offering Method and Pricing of IPOs: An Analysis of Stock IPOs in the Netherlands, 1918–1939
Authors: Legierse Wilco 
Published: August 2023

AbstractResearch into the benefits of underwritten issues has been conducted primarily in settings that exhibit information asymmetries between issuing firms, financial intermediaries, and investors. This paper examines, during the interwar period, an era characterized by longstanding relationships between issuers, banks, and investors, the pricing and choice of method for offering shares of Dutch IPOs. Offering method in this setting is related mainly to the volume of the issue open for subscription prior to listing. The larger the volume, the more firms tended towards an underwritten offering. The pricing is found to be unrelated to offering method as well as to variables that theoretically proxy information asymmetries. The relatively low level of underpricing largely fluctuates with past investor sentiment.
Plant and soil N of different winter cover crops as green manure for subsequent organic white cabbage
Authors: Stein Sophie , Hartung Jens , Perkons Ute , Möller Kurt , Zikeli Sabine 
Published: August 2023

AbstractLeguminous cover crops used as green manures can reduce fertilizer inputs by supplying nitrogen (N) via mineralization of incorporated N-rich biomass derived from biological N2 fixation. In a multi-year trial at three locations in Germany, the effects of leguminous, non-leguminous and mixed green manure crops on the yield of the subsequent cash crop white cabbage (Brassica oleracea convar. capitata var. alba) were investigated. The winter cover crop treatments were forage rye (Secale cereale L.), a mixture of forage rye with winter Hungarian vetch (Vicia pannonica Crantz), sole-cropped winter Hungarian vetch, winter pea (Pisum sativum L.), and winter faba bean (Vicia faba L.) with bare soil as a control. Sole-cropped legumes showed higher marketable cabbage head yields (head weight > 1.0 kg) compared to the other cover crop treatments, with 25.5, 25.9 and 28.1 Mg ha− 1 for vetch, pea and faba bean, respectively. The aboveground biomass of the legume winter cover crop treatments had higher N offtakes with 185, 177 and 159 kg N ha− 1 for vetch, pea and faba bean, respectively, with significantly lower carbon (C)/N ratios compared to rye and rye with vetch. The constant C/N ratio of the aboveground biomass of leguminous cover crops throughout the growing period indicates that the optimum incorporation date to achieve high N mineralization rates is less time dependent in leguminous compared to non-leguminous cover crops. The results of the present study show that leguminous winter cover crops do not reduce the soil N availability for a succeeding high N demanding cabbage crop resulting in yields comparable to agricultural practice without winter cover crops.
The Spiritual Aspect of Pain: An Integrative Review
Authors: De-Diego-Cordero Rocío , Velasco-Domínguez Cristina , Aranda-Jerez Alicia , Vega-Escaño Juan 
Published: August 2023

AbstractPain is an unpleasant sensory and emotional experience that affects individuals in various ways involving biological, psychological, social, and spiritual aspects. There is currently no comprehensive treatment that effectively addresses all aspects of pain. This integrative review aimed to analyze the spiritual aspect of pain relief. Following the specified methodological criteria, a total of 20 articles were selected. There evidenced a lack of spiritual care provided by healthcare professionals, even though its correlation with pain and its potential benefits have been widely demonstrated in the literature. Fortunately, some patients put into practice existential and religious tools to self-control and cope with their pain, although not always with a successful response.
Religious reforms and large-scale rebellions (via the case of the Honganji sect of the True Pure Land Buddhism)
Authors: Maltsev Vladimir 
Published: August 2023

AbstractThe paper explores the economics behind two large-scale rebellions in Japan throughout 1532–1536 and 1570–1580, launched by a religious organization called Honganji. The paper argues that Honganji’s large-scale rebellions took off primarily due to religious reforms, particularly, the creation of an after-life pardon doctrine, which enabled the functioning of more potent incentives that fostered participation. First, the doctrine raised the costs of not joining a rebellion by excluding the non-participants and consigning them to hell. This resulted in immediate spiritual, social and economic penalties, as condemned individuals were considered religiously corrupt and were expelled from the sect’s temple towns and sect-dominated village communities. Second, the after-life pardon doctrine reduced the costs of rebellious participation by guaranteeing an instant rebirth in paradise after dying for the sect’s cause. As many individuals at the time saw the world through the lens of religion and spirituality, the guarantee of paradise was an especially potent incentive to join a rebellion.
Toxic effects of AB-CHMINACA on liver and kidney and detection of its blood level in adult male mice
Authors: Mohammad Soheir Ali , Mousa Rasha Elhaddad Ali , Gebril Sahar Mohamed , Masoud Khaled Masoud Mohamed , Radwan Rania Ahmad 
Published: August 2023

Abstract
Background
AB-CHMINACA is a cannabimimetic indazole derivative. In 2013, it was reported in different countries as a substance of abuse.

Purpose
This study evaluated the subacute toxic effects of AB-CHMINACA on the liver and kidneys and measured its blood level in adult male mice.

Methods
The histological and biochemical subacute toxic effects on the liver and kidneys were assessed after four weeks of daily intraperitoneal injections of one of the following doses: 0.3 mg/kg, 3 mg/kg, or 10 mg/kg as the highest dose in adult male albino mice. In addition, the blood concentration level of AB-CHMINACA was determined by GC–MS-MS.

Results
The histological effects showed congestion, hemorrhage, degeneration, and cellular infiltration of the liver and kidney tissues. Considering the control groups as a reference, biochemical results indicated a significant increase in the serum AST only in the highest dose group, while the ALT and creatinine levels did not significantly change. The mean values of AB-CHMINACA blood levels were 3.05 ± 1.16, 15.08 ± 4.30, and 54.43 ± 8.70 ng/mL for the three treated groups, respectively, one hour after the last dose of intraperitoneal injection. The calibration curves were linear in the 2.5–500 ng/mL concentration range. The intra-assay precision and accuracy of the method were less than 7.0% (RSD) and ± 9.2% (Bias).

Conclusion
This research supports the available case reports on AB-CHMINACA toxicity that it has low lethality; still, the chronic administration causes evident liver and kidney histotoxic effects even at low doses with unnoticeable clinical effects in mice.
Distributions of Visual Receptive Fields from Retinotopic to Craniotopic Coordinates in the Lateral Intraparietal Area and Frontal Eye Fields of the Macaque
Authors: Yang Lin , Jin Min , Zhang Cong , Qian Ning , Zhang Mingsha 
Published: August 2023

AbstractEven though retinal images of objects change their locations following each eye movement, we perceive a stable and continuous world. One possible mechanism by which the brain achieves such visual stability is to construct a craniotopic coordinate by integrating retinal and extraretinal information. There have been several proposals on how this may be done, including eye-position modulation (gain fields) of retinotopic receptive fields (RFs) and craniotopic RFs. In the present study, we investigated coordinate systems used by RFs in the lateral intraparietal (LIP) cortex and frontal eye fields (FEF) and compared the two areas. We mapped the two-dimensional RFs of neurons in detail under two eye fixations and analyzed how the RF of a given neuron changes with eye position to determine its coordinate representation. The same recording and analysis procedures were applied to the two brain areas. We found that, in both areas, RFs were distributed from retinotopic to craniotopic representations. There was no significant difference between the distributions in the LIP and FEF. Only a small fraction of neurons was fully craniotopic, whereas most neurons were between the retinotopic and craniotopic representations. The distributions were strongly biased toward the retinotopic side but with significant craniotopic shifts. These results suggest that there is only weak evidence for craniotopic RFs in the LIP and FEF, and that transformation from retinotopic to craniotopic coordinates in these areas must rely on other factors such as gain fields.
Be a Mom Coping with Depression: a Feasibility Study of a Blended Cognitive-Behavioral Intervention for Postpartum Depression
Authors: Branquinho Mariana , Canavarro Maria Cristina , Fonseca Ana 
Published: August 2023

AbstractA blended cognitive-behavioral intervention for postpartum depression (Be a Mom Coping with Depression) was developed, consisting of the combination of seven face-to-face sessions (delivered through videocall) with six online sessions in a web-based program. This study aimed to assess the intervention’s feasibility, acceptability, and preliminary effects on depressive symptoms. A single-arm pre- and post-test study was conducted, and adult Portuguese women in the postpartum period (up to 12 months) with a clinical diagnosis of a major depressive episode were eligible to participate (n = 9). Participants completed self-report measures and were interviewed after completing the intervention. Eight participants completed the blended intervention. The recruitment rate was low, but the adherence to treatment was high. Participants reported several advantages of this intervention and high levels of satisfaction. The blended intervention was found to be feasible and acceptable, and a reduction on depressive symptoms was observed in our sample. These results support the conduction of a randomized controlled trial to assess the efficacy of this blended intervention and provided important information to proceed with the necessary modifications.
RETRACTED ARTICLE: Network Attribute Analysis and Competitiveness Evaluation of Auto Parts Industry Cluster for e-Commerce Platform
Authors: Meng Xiangling 
Published: August 2023

AbstractThe automotive parts industry cluster is a complex operating system, and it is no longer possible to use a simple theory to make a scientific and reasonable explanation for the parts industry cluster. In view of this, the study takes the automotive parts industry cluster as the research object, innovatively invokes the theory of organizational ecology and constructs a competitiveness analysis mechanism based on population co-evolution. The study conducts performance analysis and simulation tests on the constructed model, integrating the CS–AHP evaluation method to evaluate the competitiveness of the parts industry cluster. The performance comparison results show that the research method has a minimum training error of 0.0108, when the number of iterations of the system is 69th. This method has a stable loss function value at the fifth iteration, which is a stable convergence state earlier than the GA algorithm, differential evolution and distribution estimation algorithm. The A-level index score of the off-line platform auto parts industry cluster is 0.5174, which is significantly greater than 0.5. The competitive cooperation effect, technological innovation effect and cluster culture scores of the e-commerce platform are 0.5885, 0.6899 and 0.5329, respectively, which are significantly higher than those of the off-line. The above results show that the accuracy of the research algorithm is higher than that of the off-line industry. The above results show that the accuracy of the research algorithm is better, which can make a reasonable scientific basis for the auto parts industry and carry out competitiveness evaluation. To a certain extent, it can provide technical reference for the future development of the auto field industry.
Pore‐Scale Modeling of PFAS Transport in Water‐Unsaturated Porous Media: Air–Water Interfacial Adsorption and Mass‐Transfer Processes in Thin Water Films
Authors: Chen Sidian , Guo Bo 
Published: August 2023

AbstractAir–water interfacial adsorption complicates per‐ and polyfluoroalkyl substance (PFAS) transport in vadose zones. Air–water interfaces can arise from pendular rings between soil grains and thin water films on grain surfaces, the latter of which account for over 90% of the total air–water interfaces for most field‐relevant conditions. However, whether all thin‐water‐film air–water interfaces are accessible by PFAS and how mass‐transfer limitations in thin water films control PFAS transport in soils remain unknown. We develop a pore‐scale model that represents both PFAS adsorption at bulk capillary and thin‐water‐film air–water interfaces and the mass‐transfer processes between bulk capillary water and thin water films (including advection, aqueous diffusion, and surface diffusion along air–water interfaces). We apply the pore‐scale model to a series of numerical experiments—constrained by experimentally determined hydraulic parameters and air–water interfacial area data sets—to examine the impact of thin‐water‐film mass‐transfer limitations in a sand medium. Our analyses suggest: (a) The mass‐transfer limitations between bulk capillary water and thin water films inside a pore are negligible due to surface diffusion. (b) However, strong mass‐transfer limitations arise in thin water films of pore clusters where pendular rings disconnect. The mass‐transfer limitations lead to early arrival and long tailing behaviors even if surface diffusion is present. (c) Despite the mass‐transfer limitations, all air–water interfaces in the thin water films were accessed by PFAS under the simulated conditions. These findings highlight the importance of incorporating the thin‐water‐film mass‐transfer limitations and surface diffusion for modeling PFAS transport in vadose zones.
Similarities and differences in the functional architecture of mother- infant communication in rhesus macaque and British mother-infant dyads
Authors: Sclafani V. , De Pascalis L. , Bozicevic L. , Sepe A. , Ferrari P. F. , Murray L. 
Published: August 2023

AbstractSimilarly to humans, rhesus macaques engage in mother-infant face-to-face interactions. However, no previous studies have described the naturally occurring structure and development of mother-infant interactions in this population and used a comparative-developmental perspective to directly compare them to the ones reported in humans. Here, we investigate the development of infant communication, and maternal responsiveness in the two groups. We video-recorded mother-infant interactions in both groups in naturalistic settings and analysed them with the same micro-analytic coding scheme. Results show that infant social expressiveness and maternal responsiveness are similarly structured in humans and macaques. Both human and macaque mothers use specific mirroring responses to specific infant social behaviours (modified mirroring to communicative signals, enriched mirroring to affiliative gestures). However, important differences were identified in the development of infant social expressiveness, and in forms of maternal responsiveness, with vocal responses and marking behaviours being predominantly human. Results indicate a commonfunctional architectureof mother-infant communication in humans and monkeys, and contribute to theories concerning the evolution of specific traits of human behaviour.