bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective magnetic hyperthermia induced by mitochondria‐targeted nanoparticles modified with triphenylphosphonium‐containing phospholipid polymers
Authors: Kaneko Masahiro , Yamazaki Hiroto , Ono Takahiro , Horie Masanobu , Ito Akira 
Published: July 2023

AbstractMagnetic hyperthermia (MHT) is a promising cancer treatment because tumor tissue can be specifically damaged by utilizing the heat generated by nano‐heaters such as magnetite nanoparticles (MNPs) under an alternating magnetic field. MNPs are taken up by cancer cells, enabling intracellular MHT. Subcellular localization of MNPs can affect the efficiency of intracellular MHT. In this study, we attempted to improve the therapeutic efficacy of MHT by using mitochondria‐targeting MNPs. Mitochondria‐targeting MNPs were prepared by the modification of carboxyl phospholipid polymers containing triphenylphosphonium (TPP) moieties that accumulate in mitochondria. The mitochondrial localization of polymer‐modified MNPs was supported by transmission electron microscopy observations of murine colon cancer CT26 cells treated with polymer‐modified MNPs. In vitro and in vivo MHT using polymer‐modified MNPs revealed that the therapeutic effects were enhanced by introducing TPP. Our results indicate the validity of mitochondria targeting in enhancing the therapeutic outcome of MHT. These findings will pave the way for developing a new strategy for the surface design of MNPs and therapeutic strategies for MHT.
Unveiling the diagnostic enigma of D‐dimer testing in cancer patients: Current evidence and areas of application
Authors: Gotta Jennifer , Gruenewald Leon D. , Eichler Katrin , Martin Simon S. , Mahmoudi Scherwin , Booz Christian , Biciusca Teodora , Reschke Philipp , Bernatz Simon , Pinto Dos Santos Daniel , Scholtz Jan‐Erik , Alizadeh Leona S. , Nour‐Eldin Nour‐Eldin A. , Hammerstingl Renate M. , Gruber‐Rouh Tatjana , Mader Christoph , Hardt Stefan E. , Sommer Christof M. , Bucolo Giuseppe , D'Angelo Tommaso , Onay Melis , Finkelmeier Fabian , Leistner David M. , Vogl Thomas J. , Giannitsis Evangelos , Koch Vitali 
Published: July 2023

AbstractBackgroundCancer is a well‐known risk factor for venous thromboembolism (VTE). A combined strategy of D‐dimer testing and clinical pre‐test probability is usually used to exclude VTE. However, its effectiveness is diminished in cancer patients due to reduced specificity, ultimately leading to a decreased clinical utility. This review article seeks to provide a comprehensive summary of how to interpret D‐dimer testing in cancer patients.MethodsIn accordance with PRISMA standards, literature pertaining to the diagnostic and prognostic significance of D‐dimer testing in cancer patients was carefully chosen from reputable sources such as PubMed and the Cochrane databases.ResultsD‐dimers have not only a diagnostic value in ruling out VTE but can also serve as an aid for rule‐in if their values exceed 10‐times the upper limit of normal. This threshold allows a diagnosis of VTE in cancer patients with a positive predictive value of more than 80%. Moreover, elevated D‐dimers carry important prognostic information and are associated with VTE reoccurrence. A gradual increase in risk for all‐cause death suggests that VTE is also an indicator of biologically more aggressive cancer types and advanced cancer stages. Considering the lack of standardization for D‐dimer assays, it is essential for clinicians to carefully consider the variations in assay performance and the specific test characteristics of their institution.ConclusionsStandardizing D‐dimer assays and developing modified pretest probability models specifically for cancer patients, along with adjusted cut‐off values for D‐dimer testing, could significantly enhance the accuracy and effectiveness of VTE diagnosis in this population.
Predictors of functional outcome after symptomatic intracranial hemorrhage complicating intravenous thrombolysis: results from the SITS‐ISTR
Authors: Tsivgoulis Georgios , Palaiodimou Lina , Stefanou Maria‐Ioanna , Theodorou Aikaterini , Kõrv Janika , Nunes Ana Paiva , Candelaresi Paolo , Dall'Ora Elisa , Sariaslani Payam , Provinciali Leandro , Conforto Adriana B. , Cidrao Alan Alves de Lima , Karapanayiotides Theodore , Ahmed Niaz 
Published: July 2023

AbstractBackground and purposeSeveral risk factors of symptomatic intracerebral hemorrhage (SICH) following intravenous thrombolysis for acute ischaemic stroke have been established. However, potential predictors of good functional outcome post‐SICH have been less studied.MethodsPatient data registered in the Safe Implementation of Treatment in Stroke—International Stroke Thrombolysis Register (SITS‐ISTR) from 2005 to 2021 were used. Acute ischaemic stroke patients who developed post intravenous thrombolysis SICH according to the SITS Monitoring Study definition were analyzed to identify predictors of functional outcomes.ResultsA total of 1679 patients with reported SICH were included, out of which only 2.8% achieved good functional outcome (modified Rankin Scale scores of 0–2), whilst 80.9% died at 3 months. Higher baseline National Institutes of Health Stroke Scale (NIHSS) score and 24‐h ΔNIHSS score were independently associated with a lower likelihood of achieving both good and excellent functional outcomes at 3 months. Baseline NIHSS and hematoma location (presence of both SICHs, defined as remote and local SICH concurrently; n = 478) were predictors of early mortality within 24 h. Independent predictors of 3‐month mortality were age, baseline NIHSS, 24‐h ΔNIHSS, admission serum glucose values and hematoma location (both SICHs). Age, baseline NIHSS score, 24‐h ΔNIHSS, hyperlipidemia, prior stroke/transient ischaemic attack, antiplatelet treatment, diastolic blood pressure at admission, glucose values on admission and SICH location (both SICHs) were associated with reduced disability at 3 months (≥1‐point reduction across all modified Rankin Scale scores). Patients with remote SICH (n = 219) and local SICH (n = 964) had comparable clinical outcomes, both before and after propensity score matching.ConclusionsSymptomatic intracerebral hemorrhage presents an alarmingly high prevalence of adverse clinical outcomes, with no difference in clinical outcomes between remote and local SICH.
Resolving relationship dissolution—What predicts emotional adjustment after breakup?
Authors: Tran Kien , Castiglioni Laura , Walper Sabine , Lux Ulrike 
Published: July 2023

AbstractRelationship dissolution is a critical life event individuals have to cope with. Factors like relationship duration and relationship quality or having a new partner are likely to affect how people recover emotionally from a separation, which is linked to long‐term adjustment. However, prospective evidence on the role of these factors is scarce. Hence, this study aims to investigate predictors of emotional recovery following relationship dissolution. Pooled data of the German Family Panel pairfam on 3734 separation events of 2709 individuals aged 18 to 48 were used, applying a statistical model called seemingly unrelated regressions to predict emotional outcomes (relief, anger, guilt, and sadness) and the general emotional state regarding separation. Sociodemographic and relationship characteristics, indicators of relationship quality, conditions of the separation, and features of the current situation were considered as potential predictors. Regression analyses evidence strong links of initiator status, having a new partner, time since separation, and satisfaction with the social network to less negative emotional outcomes following separation. Relationship quality or serious problems before the separation only affected some of the investigated emotional outcomes. Interestingly, the predictors investigated were less powerful in explaining respondents' feelings of guilt compared to the other emotions. Overall, these findings provide deeper insight into short‐term adjustment to separation. Understanding these processes may help to assess risk factors for negative coping mechanisms and improve tailored counseling strategies.
Methane in West Siberia terrestrial seeps: Origin, transport, and metabolic pathways of production
Authors: Sabrekov Aleksandr F. , Terentieva Irina E. , McDermid Gregory J. , Litti Yuriy V. , Prokushkin Anatoly S. , Glagolev Mikhail V. , Petrozhitskiy Alexey V. , Kalinkin Peter N. , Kuleshov Dmitry V. , Parkhomchuk Ekaterina V. 
Published: July 2023

AbstractThe expansive plains of West Siberia contain globally significant carbon stocks, with Earth's most extensive peatland complex overlying the world's largest‐known hydrocarbon basin. Numerous terrestrial methane seeps have recently been discovered on this landscape, located along the floodplains of the Ob and Irtysh Rivers in hotspots covering more than 2500 km2. We articulated three hypotheses to explain the origin and migration pathways of methane within these seeps: (H1) uplift of Cretaceous‐aged methane from deep petroleum reservoirs along faults and fractures, (H2) release of Oligocene‐aged methane capped or trapped by degrading permafrost, and (H3) horizontal migration of Holocene‐aged methane from surrounding peatlands. We tested these hypotheses using a range of geochemical tools on gas and water samples extracted from seeps, peatlands, and aquifers across the 120,000 km2 study area. Seep‐gas composition, radiocarbon age, and stable isotope fingerprints favor the peatland hypothesis of seep‐methane origin (H3). Organic matter in raised bogs is the primary source of seep methane, but observed variability in stable isotope composition and concentration suggest production in two divergent biogeochemical settings that support distinct metabolic pathways of methanogenesis. Comparison of these parameters in raised bogs and seeps indicates that the first is bogs, via CO2 reduction methanogenesis. The second setting is likely groundwater, where dissolved organic carbon from bogs is degraded via chemolithotrophic acetogenesis followed by acetate fermentation methanogenesis. Our findings highlight the importance of methane lateral migration in West Siberia's bog‐dominated landscapes via intimate groundwater connections. The same phenomenon could occur in similar landscapes across the boreal‐taiga biome, thereby making groundwater‐fed rivers and springs potent methane sources.
Whether polycentric spatial structure is conducive to regional coordinated development: A study on urban agglomerations in China
Authors: Ji Peng , Yuan Lilin 
Published: July 2023

AbstractWith the aggravation of congestion, pollution, and other negative externalities generated by continued urbanization, polycentric strategies have gradually become one of the main urban and regional spatial strategies. It remains unclear, however, whether the polycentric structure is conducive to regional coordinated development. This study examines these issues using China's urban agglomerations (UAs) as a sample. The Prolonged Artificial Nighttime‐light Dataset of China (PANDA) was used to measure the polycentric structure. The results of the nonparametric identification of sub‐centers show that almost all of China's UAs exhibit multiple (sub)centers, and the number of (sub)centers in most UAs has increased from 1992 to 2020. Empirical analysis shows that a polycentric structure is beneficial for narrowing regional disparities within the UA, and the narrowing effect of the polycentric structure on regional disparities increases as the distance between centers increases. Furthermore, a polycentric spatial structure is more conducive to the economic growth of small cities in UA, thereby promoting the coordinated development of regions within UA.
Whole F8 gene sequencing combined with splicing functional analyses led to a substantial increase of the molecular diagnosis yield for non‐severe haemophilia A
Authors: Dericquebourg Amy , Fretigny Mathilde , Leuci Alexandre , Zawadzki Christophe , Huguenin Yoann , Castet Sabine‐Marie , Dargaud Yesim , Vinciguerra Christine , Jourdy Yohann 
Published: July 2023

AbstractIntroductionConventional genetic investigation fails to identify the F8 causal variant in 2.5%‐10% of haemophilia A (HA) patients with non‐severe phenotypes. In these cases, F8 deep intronic variants could be causal.AimTo identify pathogenic F8 deep intronic variants in genetically unresolved families with non‐severe HA analysed in the haematology laboratory of the Hospices Civils de Lyon.MethodsThe whole F8 was analysed by next generation sequencing. The pathogenic impact of candidate variants identified was assessed using both in silico analysis (MaxEntScan and spliceAI) and functional analysis (RNA or minigene assay).ResultsSequencing was performed in 49/55 families included for which a DNA sample from a male propositus was available. In total, 33 candidate variants from 43 propositi were identified. These variants corresponded to 31 single nucleotide substitutions, one 173‐bp deletion, and an 869‐bp tandem triplication. No candidate variant was found in six propositi. The most frequent variants found were the association of [c.2113+1154G>C and c.5374‐304C>T], identified in five propositi, and the c.2114‐6529C>G identified in nine propositi. Four variants had been previously described as HA‐causing. Splicing functional assay found a deleterious impact for 11 substitutions (c.671‐94G>A, c.788‐312A>G, c.2113+1154G>C, c.2114‐6529C>G, c.5999‐820A>T, c.5999‐786C>A, c.5999‐669G>T, c.5999‐669G>A, c.5999‐669G>C, c.6900+4104A>C, and c.6901‐2992A>G). The HA‐causing variant was identified in 33/49 (67%) cases. In total, F8 deep intronic variants caused 8.8% of the non‐severe HA among the 1643 families analysed in our laboratory.ConclusionThe results emphasise the value of whole F8 gene sequencing combined with splicing functional analyses to improve the diagnosis yield for non‐severe HA.
Failure behavior of SiC/SiC composites with Si/Yb2SiO5 and Si/mullite/Yb2SiO5 EBCs in wet oxygen at 1350°C
Authors: Wang Yulei , Wang Wenli , Cao Xinxin , Zhang Ziqi , Li Jianzhang , Han Guifang , Cheng Laifei 
Published: July 2023

AbstractTwo structured ytterbium monosilicate environmental barrier coatings (Si/Yb2SiO5 and Si/mullite/Yb2SiO5) were prepared on SiC/SiC composites and their performance in wet oxygen at 1350°C was investigated. After 300 h of corrosion, coating peeling occurred for Si/Yb2SiO5–SiC/SiC, while it was intact for Si/mullite/Yb2SiO5–SiC/SiC system due to the mullite intermediate coating well alleviating the thermal expansion mismatched stress. During the assessment, Yb2SiO5 and mullite gradually densified, and a thin layer of ytterbium disilicates (Yb2Si2O7) was formed at their junction as a new protective layer, which pinned into the mullite layer and significantly improved their interface bonding strength and resistance against wet oxygen. The strength retention of SiC/SiC, Si/Yb2SiO5–SiC/SiC, and Si/mullite/Yb2SiO5–SiC/SiC was 64%, 72%, and 97%, respectively, after corrosion in wet oxygen at 1350°C/300 h. Their corrosion mechanism was proposed.
Medication adherence trajectory of patients with chronic diseases and its influencing factors: A systematic review
Authors: Chen Yu , Gao Jing , Lu Minmin 
Published: July 2023

AbstractAimsTo synthesize the published studies on medication adherence trajectories among patients with chronic diseases and identify the influencing factors.DesignSystematic review.Data SourcesMedline (Ovid), Embase (Ovid) and Web of Science core collection were searched from database inception to 1 July 2022.Review MethodsPotentially eligible articles were independently screened by three reviewers using set inclusion and exclusion criteria. The Joanna Briggs Institute critical appraisal checklist for cohort studies was used to appraise the quality of the included articles. Three reviewers independently evaluated the quality, extracted data and resolved differences by consensus. Results were presented using descriptive synthesis, and the prevalence of recategorised medication adherence trajectories was calculated from the published data.ResultsFifty studies were included. Medication adherence trajectories among patients with chronic diseases were synthesized into six categories: adherence, non‐adherence, decreasing adherence, increasing adherence, fluctuating adherence and moderate adherence. Low and moderate evidence showed that (1) patient‐related factors, including age, sex, race, marital status and mental status; (2) healthcare team and system‐related factors, including healthcare utilization, insurance and primary prescriber specialty; (3) socioeconomic factors including education, income and employment status; (4) condition‐related factors including complications and comorbidities and (5) therapy‐related factors including the number of medications, use of other medications, and prior medication adherence behaviours were factors influencing the medication adherence trajectory. Marital status and prior medication adherence behaviour were the only influencing factors with moderate evidence of an effect.ConclusionThe medication adherence trajectory among patients with chronic diseases varied widely. Further studies are warranted to determine contributory factors.Implications for the ProfessionHealthcare providers should be aware that patients' medication adherence has different trajectories and should take appropriate measures to improve patients' medication adherence patterns.Patient or Public ContributionNone. As a systematic review, patients and the public were not involved.
Editorial: Developmental considerations in addressing the earlier age of severe eating disorder onset
Authors: Kamody Rebecca C. , Bloch Michael H. 
Published: July 2023

The deleterious impact of the COVID‐19 pandemic on youth mental health has garnered much attention (Newlove‐Delgado et al., 2023). It has been a topic of interest in both research and academic writing, as well as in the public press (e.g., Tanner, 2023). Disorders and mental health concerns of focus have been wide‐ranging, with some of the most severe presentations, such as suicidality, highlighted (Asarnow and Chung, 2021). Eating disorders are among the most life‐threatening and prominent mental health concerns that have been exacerbated by the pandemic, and our current models of youth mental health care cannot keep up. Given this context, our team read and reviewed the manuscript, ‘Shifting age of child eating disorder hospitalizations during the Covid‐19 pandemic’ (Auger et al., 2023), eagerly. While the increasing severity of eating disorder presentations and increase in pediatric hospitalization has been an area of research (Asch et al., 2021), including at our own institution (Shum et al., 2022), the impact of age of onset, and the consequential impact on current systems of care, requires much greater attention.
Validity of the short‐form five‐item Problem Area in Diabetes questionnaire as a depression screening tool in type 2 diabetes mellitus patients
Authors: Tay Donovan , Chua Marvin , Khoo Joan 
Published: July 2023

AbstractAims/IntroductionDepression is prevalent in diabetes patients and associated with poor outcomes, but is currently underdiagnosed, with no firm consensus on screening methods. We evaluated the validity of the short‐form five‐item Problem Areas in Diabetes (PAID‐5) questionnaire as a screening tool for depression, comparing it with the Beck Depression Inventory‐II (BDI‐II) and nine‐item Patient Health Questionnaire (PHQ‐9).Materials and MethodsA total of 208 English‐speaking adults with type 2 diabetes, recruited from outpatient clinics, completed the BDI‐II, PHQ‐9 and PAID‐5 questionnaires in English. Cronbach's α was used for internal reliability. Convergent validity was examined with BDI‐II and PHQ‐9. Receiver operating characteristics analyses were used to identify optimal PAID‐5 cut‐offs for the diagnosis of depression.ResultsAll three screening tools were highly reliable, with BDI‐II, PHQ‐9 and PAID‐5 having a Cronbach's α of 0.910, 0.870 and 0.940, respectively. There was a good correlation between BDI‐II and PHQ‐9, with a correlation co‐efficient (r) of 0.73; and a moderate correlation between PAID‐5 and PHQ‐9, and PAID‐5 and BDI‐II, with r of 0.55 and 0.55 respectively (P values <0.01). An optimal PAID‐5 cut‐off ≥9 corresponded to both a BDI‐II cut‐off >14 (sensitivity 72%, specificity 784%, area under the curve 0.809) and a PHQ‐9 cut‐off >10 (sensitivity 84%, specificity 74%, area under the curve 0.806). Using a PAID‐5 cut‐off ≥9, the prevalence of depressive symptoms was 36.1%.ConclusionsDepressive symptoms are prevalent in people with type 2 diabetes, with the degree of distress significantly related to the severity of depressive symptoms. PAID‐5 is a valid and reliable screening tool, and a score ≥9 could prompt further confirmation for depression.
Biological and behavioural responses of the sugarcane borer parasitoid Tetrastichus howardi to insecticides
Authors: Bermúdez Natalia Carolina , do Nascimento Deividy Vicente , Morato Renilson Pessoa , da Silva‐Torres Christian Sherley Araújo , Torres Jorge Braz 
Published: July 2023

AbstractThe pupal parasitoid Tetrastichus howardi (Olliff) (Hymenoptera: Eulophidae) parasitizes pupae of sugarcane stalk borers inside the stalk. Parasitoids currently used for applied biological control of sugarcane stalk borers target eggs and larvae, and T. howardi will add mortality to the pest stage with high survival. Nevertheless, insecticide applications required to control sugarcane borers and other sugarcane pests can affect T. howardi parasitism. Survival, walking, evasion and parasitism of T. howardi females were evaluated in response to the dry residue of insecticides from different chemical groups: chlorantraniliprole, bifenthrin, spinetoram, ethiprole, fipronil and thiamethoxam. Females of the parasitoid were confined on sugarcane leaves containing residues of the insecticides at 2, 24, 48, 72 and 96 h intervals after application, and survival monitored during the 96‐h period with subsequent determination of parasitism in the laboratory. Furthermore, female walking behaviour was observed individually using half‐treated arenas with insecticides. Chlorantraniliprole was compatible with T. howardi irrespective of residual intervals and studied variables. Other tested insecticides did not allow parasitoid survival up to 96 h of confinement on dry residues and, consequently, parasitism. Locomotory activity indicated that parasitoid females might avoid residues of spinetoram and ethiprole. Females were released in cages containing spinetoram and ethiprole‐treated sugarcane plants with the chance to move to untreated plants, parasitized pupae placed on either treated or untreated plants within a 24 h exposure period, which resulted in offspring production. Females observed for 10 min for walking behaviour in a half‐treated arena with chlorantraniliprole, ethiprole, fipronil, spinetoram, bifenthrin or thiamethoxam exhibited 100%, 73.3%, 70%, 66.7%, 10% and 0% survival after 24 h, respectively. Chlorantraniliprole was compatible with T. howardi through the bioassays conducted, and parasitoids showed the ability to parasitize their hosts on spinetoram‐ and ethiprole‐treated plants moving away from the treated environment.