bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation
Authors: Hing Zachary A. , Walker Janek S. , Whipp Ethan C. , Brinton Lindsey , Cannon Matthew , Zhang Pu , Sher Steven , Cempre Casey B. , Brown Fiona , Smith Porsha L. , Agostinelli Claudio , Pileri Stefano A. , Skinner Jordan N. , Williams Katie , Phillips Hannah , Shaffer Jami , Beaver Larry P. , Pan Alexander , Shin Kyle , Gregory Charles T. , Ozer Gulcin H. , Yilmaz Selen A. , Harrington Bonnie K. , Lehman Amy M. , Yu Lianbo , Coppola Vincenzo , Yan Pearlly , Scherle Peggy , Wang Min , Pitis Philip , Xu Chaoyi , Vaddi Kris , Chen-Kiang Selina , Woyach Jennifer , Blachly James S. , Alinari Lapo , Yang Yiping , Byrd John C. , Baiocchi Robert A. , Blaser Bradley W. , Lapalombella Rosa 
Published: January 2023

AbstractRichter’s Transformation (RT) is a poorly understood and fatal progression of chronic lymphocytic leukemia (CLL) manifesting histologically as diffuse large B-cell lymphoma. Protein arginine methyltransferase 5 (PRMT5) is implicated in lymphomagenesis, but its role in CLL or RT progression is unknown. We demonstrate herein that tumors uniformly overexpress PRMT5 in patients with progression to RT. Furthermore, mice with B-specific overexpression of hPRMT5 develop a B-lymphoid expansion with increased risk of death, and Eµ-PRMT5/TCL1 double transgenic mice develop a highly aggressive disease with transformation that histologically resembles RT; where large-scale transcriptional profiling identifies oncogenic pathways mediating PRMT5-driven disease progression. Lastly, we report the development of a SAM-competitive PRMT5 inhibitor, PRT382, with exclusive selectivity and optimal in vitro and in vivo activity compared to available PRMT5 inhibitors. Taken together, the discovery that PRMT5 drives oncogenic pathways promoting RT provides a compelling rationale for clinical investigation of PRMT5 inhibitors such as PRT382 in aggressive CLL/RT cases.
A new extended single-switch high gain DC–DC boost converter for renewable energy applications
Authors: Mansour Arafa S. , Zaky Mohamed S. 
Published: January 2023

AbstractHigh-gain DC/DC converters are considered one of the most important components of green energy systems. Large numbers of these converters are used for increasing the voltage gain by using an extreme duty cycle. However, it increases losses and the cost, degrades the system performance, and hence obtains a low efficiency. In this article, a new design of a high-gain DC/DC boost converter is proposed. This converter has the potential to be used in low input voltage applications that need a high voltage gain such as systems powered by solar photovoltaic panels and fuel cells. The new topology is characterized by its simplicity of operation, high voltage gain, better efficiency, continuity of the input current, reduced number of inductors and capacitors, and can be extended to get higher gains. The converter structure, principle of operation, and design consideration of inductors and capacitors are presented in detail. Derivation of power losses and efficiency is presented. A laboratory prototype is implemented, and various experimental tests are given. The achievement of the suggested design is confirmed and compared with other recent high-gain converters.
Towards sweetness classification of orange cultivars using short-wave NIR spectroscopy
Authors: Zeb Ayesha , Qureshi Waqar Shahid , Ghafoor Abdul , Malik Amanullah , Imran Muhammad , Mirza Alina , Tiwana Mohsin Islam , Alanazi Eisa 
Published: January 2023

AbstractThe global orange industry constantly faces new technical challenges to meet consumer demands for quality fruits. Instead of traditional subjective fruit quality assessment methods, the interest in the horticulture industry has increased in objective, quantitative, and non-destructive assessment methods. Oranges have a thick peel which makes their non-destructive quality assessment challenging. This paper evaluates the potential of short-wave NIR spectroscopy and direct sweetness classification approach for Pakistani cultivars of orange, i.e., Red-Blood, Mosambi, and Succari. The correlation between quality indices, i.e., Brix, titratable acidity (TA), Brix: TA and BrimA (Brix minus acids), sensory assessment of the fruit, and short-wave NIR spectra, is analysed. Mix cultivar oranges are classified as sweet, mixed, and acidic based on short-wave NIR spectra. Short-wave NIR spectral data were obtained using the industry standard F-750 fruit quality meter (310–1100 nm). Reference Brix and TA measurements were taken using standard destructive testing methods. Reference taste labels i.e., sweet, mix, and acidic, were acquired through sensory evaluation of samples. For indirect fruit classification, partial least squares regression models were developed for Brix, TA, Brix: TA, and BrimA estimation with a correlation coefficient of 0.57, 0.73, 0.66, and 0.55, respectively, on independent test data. The ensemble classifier achieved 81.03% accuracy for three classes (sweet, mixed, and acidic) classification on independent test data for direct fruit classification. A good correlation between NIR spectra and sensory assessment is observed as compared to quality indices. A direct classification approach is more suitable for a machine-learning-based orange sweetness classification using NIR spectroscopy than the estimation of quality indices.
Luminescent Cd coordination polymer based on thiazole as a dual-responsive chemosensor for 4-nitroaniline and CrO42− in water
Authors: Karbalaee Hosseini Akram , Tadjarodi Azadeh 
Published: January 2023

AbstractA novel highly fluorescent cadmium metal–organic framework, [Cd (DPTTZ) (OBA)] (IUST-3), synthesized by using two linkers 2, 5-di (pyridine-4-yl) thiazolo [5, 4-d] thiazole (DPTTZ) and 4, 4′-oxybis (benzoic acid) (OBA) simultaneously, which exhibits a two-dimensional framework. The characteristics of this Cd-MOF were investigated by single-crystal X-ray diffraction, Fourier transform infrared spectroscopy, elemental analysis, powder X-ray diffraction, and thermogravimetry analysis. The IUST-3 exhibits excellent luminescence property and good stability in water. Luminescent experiments indicate that the IUST-3 has remarkable sensitivity and selectivity for the detection of 4-nitroaniline (4-NA), and CrO42− anion with KSV = 1.03 × 105 M-1 (4-NA) and KSV = 2.93 × 104 M-1 (CrO42−) and low limit of detection 0.52 µM (4-NA) and 1.37 µM (CrO42−). In addition, the possible fluorescence quenching mechanism was explored in this paper.
Expression of LIM domain-binding 3 (LDB3), a striated muscle Z-band alternatively spliced PDZ-motif protein in the nervous system
Authors: Blech-Hermoni Yotam , Subedi Kalpana , Silver Maya , Jensen Leah , Coscia Stephen , Kates Malcolm M. , Zhao Yongmei , Raley Castle , Edwards Nancy , Tran Bao , Ray-Chaudhary Abhik , Pathak Pankaj , Mankodi Ami 
Published: January 2023

AbstractLIM domain-binding 3 (LDB3) is a member of the Enigma family of PDZ–LIM proteins. LDB3 has been reported as a striated muscle-specific Z-band alternatively spliced protein that plays an important role in mechanosensory actin cytoskeleton remodeling. This study shows that LDB3 is broadly expressed in the central and peripheral nervous system of human and mouse. LDB3 is predominantly expressed in the adult stages compared to early development and at a significantly higher level in the spinal cord than in the brain. As in skeletal muscle and heart, LDB3 is extensively alternatively spliced in the neurons. Three novel splice isoforms were identified suggesting splicing-dependent regulation of LDB3 expression in the nervous system. Expression of LDB3 in the motor cortex, cerebellum, spinal motor neuron, peripheral nerve, and neuromuscular junction in addition to skeletal muscle indicates important roles for this PDZ–LIM family protein in motor planning and execution. Moreover, expression in the hippocampal neurons suggests roles for LDB3 in learning and memory. LDB3 interactors filamin C and myotilin are also expressed in the spinal motor neuron, nerve, and neuromuscular junction, thereby providing the basis for neurogenic manifestations in myopathies associated with mutations in these so-called muscle proteins.
Future world cancer death rate prediction
Authors: Gaidai Oleg , Yan Ping , Xing Yihan 
Published: January 2023

AbstractCancer is a worldwide illness that causes significant morbidity and death and imposes an immense cost on global public health. Modelling such a phenomenon is complex because of the non-stationarity and complexity of cancer waves. Apply modern novel statistical methods directly to raw clinical data. To estimate extreme cancer death rate likelihood at any period in any location of interest. Traditional statistical methodologies that deal with temporal observations of multi-regional processes cannot adequately deal with substantial regional dimensionality and cross-correlation of various regional variables. Setting: multicenter, population-based, medical survey data-based biostatistical approach. Due to the non-stationarity and complicated nature of cancer, it is challenging to model such a phenomenon. This paper offers a unique bio-system dependability technique suited for multi-regional environmental and health systems. When monitored over a significant period, it yields a reliable long-term projection of the chance of an exceptional cancer mortality rate. Traditional statistical approaches dealing with temporal observations of multi-regional processes cannot effectively deal with large regional dimensionality and cross-correlation between multiple regional data. The provided approach may be employed in numerous public health applications, depending on their clinical survey data.
Sleep quality among undergraduate medical students in Rwanda: a comparative study
Authors: Nsengimana Amon , Mugabo Eric , Niyonsenga Japhet , Hategekimana Jean Claude , Biracyaza Emmanuel , Mutarambirwa Renauvat , Ngabo Emile , Nduwayezu Richard 
Published: January 2023

AbstractDespite the abundance of literature highlighting poor sleep quality among medical students and its detrimental impact on their mental well-being and academic performance, no study has been conducted to investigate the sleep quality of undergraduate medical students in Rwanda to date. Therefore, this study sought to determine the magnitude of sleep quality of undergraduate medical students in Rwanda and to compare the scores of seven components of sleep quality across classes. This cross-sectional study was conducted among 290 undergraduate medical students aged 18–35 years (mean = 24, SD = 2.9) randomly recruited countrywide from 1st November 2021 to 1st March 2022. The questionnaire was self-administered with 2 sections: characteristics of medical students, and Pittsburgh Sleep Quality Index (PSQI). The Pearson Chi-square test was used to test whether the categories of seven components of sleep quality differ between classes, then ANOVA followed by the post hoc test was used to test if the seven components and global score of Pittsburgh Sleep Quality Index differ between classes. The results revealed that the global PSQI mean score was 7.73 (SD = 2.83), with fifth-year medical students reporting the highest PSQI mean score (M = 8.44, SD = 2.77), followed by first-year (M = 8.15, SD = 3.31). One-way ANOVA showed that the global PSQI score (F = 2.76, p = 0.028), subjective sleep quality (F = 3.35, p = 0.011), habitual sleep efficiency (F = 10.20, p < 0.001), and daytime dysfunction (F = 3.60, p = 0.007) were significantly different across classes. Notably, the post hoc test revealed significant scores differences in the global PSQI score between class II and V (p = 0.026), in subjective sleep quality between class I and II (p = 0.043), and between class I and IV (p = 0.016); habitual sleep efficiency between class V and all other classes (p < 0.001); and daytime dysfunction between class III and IV (p = 0.023). This paper concludes by arguing that poor sleep quality is highly prevalent among medical students in Rwanda, with final and first-year students reporting the poorest sleep quality. There were significant differences across classes in the global PSQI, subjective sleep quality, habitual sleep efficiency, and daytime dysfunction. Intervention approaches such as sleep education, behavioral changes, and relaxing techniques are recommended to address contributing factors and ultimately maximize the academic goals of Rwandan medical students.
Analysing spectral lines in Gaia low-resolution spectra
Authors: Weiler M. , Carrasco J. M. , Fabricius C. , Jordi C. 
Published: January 2023

Context. With its third data release, European Space Agency’s Gaia mission has published the first set of low-resolution spectra for a large number of celestial objects. However, these spectra differ in their nature from typical spectroscopic data, as they do not consist of wavelength samples with associated flux values. Instead, they are represented by a linear combination of Hermite functions.
Aims. We derive an approach to studying spectral lines that is robust and efficient for spectra that are represented as a linear combination of Hermite functions.
Methods. For this purpose, we combined established computational methods for orthogonal polynomials with the peculiar mathematical properties of Hermite functions and basic properties of the Gaia spectrophotometers. In particular, we made use of simple computatios for the derivatives of linear combinations of Hermite functions and their roots.
Results. A simple and efficient computational method for deriving the position in wavelength, statistical significance, and line strengths is presented for spectra represented by a linear combination of Hermite functions. The derived method is fast and robust enough to be applied to large numbers of Gaia spectra without the need for high-performance computing resources or human interference. We present example applications to hydrogen Balmer lines, He I lines, and a broad interstellar band in Gaia DR3 low-resolution spectra.
Sterberisiko für Mundhöhlen- und Oropharynxkarzinome in Thüringen: eine bevölkerungsbasierte Analyse
Authors: Kouka Mussab , Landgraf Josefin , Büntzel Jens , Kaftan Holger , Böger Daniel , Mueller Andreas , Schultze-Mosgau Stefan , Ernst Thomas , Guntinas-Lichius Orlando 
Published: January 2023

Zusammenfassung
Hintergrund Diese populationsbezogene Studie untersuchte den
Einfluss der HPV-Assoziation auf das Gesamtüberleben (OS) von Mundhöhlen- (OSCC) und
Oropharynxkarzinomen (OPSCC) in Thüringen und die Inzidenz der HPV-positiven (HPV+) und
HPV-negativen (HPV-) Tumoren.
Methoden Insgesamt wurden alle 308 Thüringer Patienten (83,4 %
Männer; medianes Alter 58 Jahre) mit der Erstdiagnose eines OSCC (38%) oder OPSCC (62%) aus
dem Jahr 2008 in die Studie aufgenommen. Nach der Risikoklassifikation nach Ang wurden
Patienten in ein geringes Sterberisiko (HPV+, Nichtraucher), intermediäres Risiko (HPV+,
Raucher) und hohem Sterberisiko (HPV-, Raucher) eingeteilt. Kaplan-Meier-Analysen und eine
multivariable Regressionsanalyse nach Cox wurden durchgeführt, um das OS zu
untersuchen.
Ergebnisse 22,5% der OPSCC war HPV+ (davon 80,1% Raucher;
Inzidenz: 1,89/100.000 Einwohner). Bei OSCC lag der Anteil der HPV+ bei 8,5% (davon 78,6%
Raucher; Inzidenz: 0,44/100.000). Der mediane Follow-up betrug 31 Monate. HPV+ Patienten
hatten eine signifikant bessere 5-Jahres-OS als HPV-Patienten (81 % vs. 49 %; p < 0,001).
In der multivariablen Analyse ergab sich ein höheres Sterberisiko für: HPV-Patienten (Hazard
Ratio [HR] = 3,2; 95%-Konfidenzintervall [KI]: 1,6–6,4; p = 0,001), eine hohe Risikoklasse
nach Ang (HR = 2,3; 95%-KI: 1,0–5,4; p = 0,049), höheres Alter (HR = 1,7; 95%-KI = 1,1–2,4; p = 0,01), T3/T4 Tumoren (HR = 2,1; 95%-KI = 1,3–3,2; p = 0,001) und das Vorhandensein
von Fernmetastasen (HR = 2,7; 95%-KI = 1,6–4,4; p < 0,001).
Schlussfolgerung HPV+ Nichtraucher waren in Thüringen eine
Minderheit. Die Mehrheit der HPV+ Patienten in Thüringen wiesen durch den Nikotinkonsum als
Risikofaktor ein intermediäres Sterberisiko auf.
Evidence-Based Medicine for Mandible Fracture Repair: Current Controversies and Future Opportunities
Authors: Barrett Thomas , Chi John 
Published: January 2023

AbstractMandibular fractures are among the most common facial fractures resulting from trauma. The nature of the injury, involved facial structures, presence of associated injuries, the dental status of the patient, comorbid conditions, and psychosocial context all must be considered by the surgeon when planning the optimal treatment for these patients. While consensus exists for many aspects of the management of mandibular trauma, some elements remain controversial. Three such topics—antibiotic therapy, treatment of subcondylar fractures, and management of the third molar—remain particularly controversial, with significant heterogeneity in practice patterns and without widely accepted evidence-based guidelines to standardize care. The goals of this work are to (1) review the historical perspective underlying these controversies, (2) summarize recent evidence shaping the current debate, and (3) highlight opportunities for continued efforts to identify best practices.
State of the Evidence for Facial Skin Cancer Reconstruction
Authors: Desisto Nicole G. , Ortiz Alexandra S. , Yang Shiayin F. , Stephan Scott J. , Patel Priyesh N. 
Published: January 2023

AbstractThis review provides a comprehensive presentation of the evidence available in facial reconstruction post-Mohs micrographic surgery. Given the large diversity in post-Mohs reconstruction, there are limited guidelines in the management of defects. The aim of the present work is to provide a review of the best evidence as it pertains to several considerations in facial reconstruction. Data suggests that Mohs micrographic surgery and many reconstructive procedures can be performed as outpatient procedures under local anesthesia, with narcotic pain medication only given in certain patient populations following a minority of reconstructive procedures. Perioperative and topical antibiotics are generally not indicated. Aspirin and warfarin can generally be continued for most reconstructive procedures, but clopidogrel and novel anticoagulants may predispose to increased bleeding complications. Delayed reconstruction appears to be safe, although data are discordant on this topic. No specific wound closure technique or suture choice appears to be consistently superior. Given the lack of robust comparative studies, consistent methodology, and variable defect sizes/locations, no robust evidence-based guidelines can be generated for reconstruction techniques of facial subsites.
A RE-AIM Evaluation of a Visualization-Based Electronic Patient-Reported Outcome System
Authors: Turchioe Meghan Reading , Mangal Sabrina , Goyal Parag , Axsom Kelly , Myers Annie , Liu Lisa G. , Lee Jessie , Campion Thomas R. , Creber Ruth Masterson 
Published: January 2023

Abstract
Objectives Health care systems are primarily collecting patient-reported outcomes (PROs) for research and clinical care using proprietary, institution- and disease-specific tools for remote assessment. The purpose of this study was to conduct a Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) evaluation of a scalable electronic PRO (ePRO) reporting and visualization system in a single-arm study.
Methods The “mi.symptoms” ePRO system was designed using gerontechnological design principles to ensure high usability among older adults. The system enables longitudinal reporting of disease-agnostic ePROs and includes patient-facing PRO visualizations. We conducted an evaluation of the implementation of the system guided by the RE-AIM framework. Quantitative data were analyzed using basic descriptive statistics, and qualitative data were analyzed using directed content analysis.
Results Reach—the total reach of the study was 70 participants (median age: 69, 31% female, 17% Black or African American, 27% reported not having enough financial resources). Effectiveness—half (51%) of participants completed the 2-week follow-up survey and 36% completed all follow-up surveys. Adoption—the desire for increased self-knowledge, the value of tracking symptoms, and altruism motivated participants to adopt the tool. Implementation—the predisposing factor was access to, and comfort with, computers. Three enabling factors were incorporation into routines, multimodal nudges, and ease of use. Maintenance—reinforcing factors were perceived usefulness of viewing symptom reports with the tool and understanding the value of sustained symptom tracking in general.
Conclusion Challenges in ePRO reporting, particularly sustained patient engagement, remain. Nonetheless, freely available, scalable, disease-agnostic systems may pave the road toward inclusion of a more diverse range of health systems and patients in ePRO collection and use.
Understanding Health Disparities in Preeclampsia: A Literature Review
Authors: Conklin Mary B. , Wells Brittney M. , Doe Emily M. , Strother Athena M. , Tarasiewicz Megan E. Burnett , Via Emily R. , Conrad Lesley B. , Farias-Eisner Robin 
Published: January 2023

Preeclampsia is a multifactorial pathology with negative outcomes in affected patients in both the peripartum and postpartum period. Black patients in the United States, when compared to their White and Hispanic counterparts, have higher rates of preeclampsia. This article aims to review the current literature to investigate how race, social determinants of health, and genetic profiles influence the prevalence and outcomes of patients with preeclampsia. Published studies utilized in this review were identified through PubMed using authors' topic knowledge and a focused search through a Medline search strategy. These articles were thoroughly reviewed to explore the contributing biosocial factors, genes/biomarkers, as well as negative outcomes associated with disparate rates of preeclampsia. Increased rates of contributing comorbidities, including hypertension and obesity, which are largely associated with low access to care in Black patient populations lead to disparate rates of preeclampsia in this population. Limited research shows an association between increased rate of preeclampsia in Black patients and specific APOL1, HLA-G, and PP13 gene polymorphisms as well as factor V Leiden mutations. Further research is required to understand the use of certain biomarkers in predicting preeclampsia within racial populations. Understanding contributing biosocial factors and identifying genes that may predispose high-risk populations may help to address the disparate rates of preeclampsia in Black patients as described in this review. Further research is required to understand if serum, placental, or urine biomarkers may be used to predict individuals at risk of developing preeclampsia in pregnancy.
Key Points
Invasive Epilepsy Monitoring: The Switch from Subdural Electrodes to Stereoelectroencephalography
Authors: Coorg Rohini , Seto Elaine S. 
Published: January 2023

AbstractStereoelectroencephalography (SEEG) has experienced an explosion in use due to a shifting understanding of epileptic networks and wider application of minimally invasive epilepsy surgery techniques. Both subdural electrode (SDE) monitoring and SEEG serve important roles in defining the epileptogenic zone, limiting functional deficits, and formulating the most effective surgical plan. Strengths of SEEG include the ability to sample difficult to reach, deep structures of the brain without a craniotomy and without disrupting the dura. SEEG is complementary to minimally invasive epilepsy treatment options and may reduce the treatment gap in patients who are hesitant about craniotomy and surgical resection. Understanding the strengths and limitations of SDE monitoring and SEEG allows epileptologists to choose the best modality of invasive monitoring for each patient living with drug-resistant seizures.