bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
Authors: Mitchell Constance A. , Burden Natalie , Bonnell Mark , Hecker Markus , Hutchinson Thomas H. , Jagla Magdalena , LaLone Carlie A. , Lagadic Laurent , Lynn Scott G. , Shore Bryon , Song You , Vliet Sara M. , Wheeler James R. , Embry Michelle R. 
Published: February 2023

Abstract
Multiple in vivo test guidelines focusing on the estrogen, androgen, thyroid, and steroidogenesis pathways have been developed and validated for mammals, amphibians, or fish. However, these tests are resource-intensive and often use a large number of laboratory animals. Developing alternatives for in vivo tests is consistent with the replacement, reduction, and refinement principles for animal welfare considerations, which are supported by increasing mandates to move toward an “animal-free” testing paradigm worldwide. New approach methodologies (NAMs) hold great promise to identify molecular, cellular, and tissue changes that can be used to predict effects reliably and more efficiently at the individual level (and potentially on populations) while reducing the number of animals used in (eco)toxicological testing for endocrine disruption. In a collaborative effort, experts from government, academia, and industry met in 2020 to discuss the current challenges of testing for endocrine activity assessment for fish and amphibians. Continuing this cross-sector initiative, our review focuses on the current state of the science regarding the use of NAMs to identify chemical-induced endocrine effects. The present study highlights the challenges of using NAMs for safety assessment and what work is needed to reduce their uncertainties and increase their acceptance in regulatory processes. We have reviewed the current NAMs available for endocrine activity assessment including in silico, in vitro, and eleutheroembryo models. New approach methodologies can be integrated as part of a weight-of-evidence approach for hazard or risk assessment using the adverse outcome pathway framework. The development and utilization of NAMs not only allows for replacement, reduction, and refinement of animal testing but can also provide robust and fit-for-purpose methods to identify chemicals acting via endocrine mechanisms. Environ Toxicol Chem 2023;42:757–777. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Changes in urban green spaces in coastal cities and human well‐being: The case of Cape Coast Metropolis, Ghana
Authors: Duku Eric , Mensah Collins Adjei , Amadu Iddrisu , Adzigbli Wonder Kofi 
Published: February 2023

AbstractGreen spaces are fast depleting in many urban areas across the world. This contributes to carbon dioxide emissions and affects the local climate and well‐being of city residents. Yet, there is limited empirical research on the spatio‐temporal patterns of change in urban green spaces and linkages to human well‐being, especially in coastal cities where urban green spaces additionally act as critical flood controls. This paper assesses the changing pattern of green space cover in Cape Coast Metropolis and the factors associated with the perceived well‐being of residents. Using a mixed‐methods design, we obtained open‐source geospatial data and gathered primary data through field observations, and in‐depth and semi‐structured interviews. These data were analysed using geospatial, statistical, and textual techniques. The results show that, from 1991 to 2018, the metropolis lost 26.57 km2 (21.66%) of its green space cover. The major land use change observed is the conversion of green spaces and wetlands into built‐up areas. The well‐being of residents related to green space use in the metropolis is associated with individuals' age and gender; the presence of good quality green space, its accessibility, and perceived importance; frequency of visits; and the time spent in the green space. The findings suggest the need for the integration of nature into urban development planning and policy, and enforcement of development controls to protect green spaces and enhance the well‐being of residents.
Soft sedimentary rocks and their boreability characteristics in mechanised tunnelling projects
Authors: Hassanpour Jafar , Goodarzi Saeed , Yagiz Saffet , Rostami Jamal , Davari Sarem Milad 
Published: February 2023

AbstractSoft sedimentary rocks are frequently found in many mountainous regions of the world like Zagros Mountains located in the south and west of Iran, where most of Iran's water conveyance projects have been constructed or are under construction. These rocks usually contain considerable amounts of different types of clay minerals. The clay mineral‐rich rocks cause many problems in the deep and long mechanised tunnelling projects. In particular, the boreability of these rocks is very different from other rocks, and due to their plastic behaviour and the lack of complete formation of chips during the cutting process by disc cutters, the prediction of cutterhead penetration in these rocks, with existing models, is often inaccurate. In this paper, a new model for estimating the disc cutter penetration in these rocks is introduced, which is based on data obtained from the main tunnelling projects completed in sedimentary rocks of Zagros Mountains. Then, the validity of the developed model is checked using actual data obtained from a tunnel recently constructed in the area. The new model can offer a more accurate estimate of machine performance in similar rocks.
Environmental sustainability in healthcare: Time to make outpatient care in orthopaedics and rheumatology greener
Authors: Tsagkaris Christos , Nikolakea Melina , Laskaratou Emmanouela Dionysia , Samaras Christos , Huang Helen , Laubscher Lily , Bobirca Anca 
Published: February 2023

AbstractIntroductionChronic musculoskeletal conditions affect billions of individuals and constitute the greatest contributor to disability worldwide. Climate change has a negative impact on these conditions, causing a rising number of patients seeking medical attention in outpatient orthopaedic and rheumatology clinics. Due to the COVID‐19 pandemic, the delivery of care by these facilities tends to become more energy‐intensive due to the increased usage of protective equipment and testing for the purpose of maintaining hygienic conditions. Therefore, practitioners and health bodies in the field need to take action to make their practice more environmentally sustainable and protect both the environment and their patients.MethodsThe authors searched peer reviewed and grey literature for relevant sources.ResultsThe present review of the literature provides an overview of the environmental pollution associated with outpatient musculoskeletal care and discusses evidence‐based recommendations from previous studies.ConclusionTelemedicine, rationalised use of consumables and equipment, physician‐led climate advocacy and patient education have a major potential to turn the tide.
Polarization effects on intermolecular vibrational energy transfer analyzed by 2DIR spectroscopy
Authors: Villaeys Albert A. , Liang Kuo Kan 
Published: February 2023

AbstractIn the present work, we analyze the influence of the polarization effects taking place during the course of a 2DIR spectroscopy experiment performed on a molecular system undergoing an intermolecular vibrational energy transfer process. When both donor and acceptor molecules participating in the vibrational energy transfer are embedded in a host solvent, they face rotational diffusion that strongly distorts the resulting 2DIR spectra. It could be expected that the difference between rotational diffusion constants will be of particular interest. For this purpose, the polarization effects are discussed according to the different orderings of the laser‐molecule interactions. Next, we study the distortions of the spectra as a function of the rotational diffusion constants of the individual molecules. The knowledge of these polarization effects is relevant to the interpretation of the spectra. Finally, the conclusions reached in this work for a vibrational energy transfer are valid for any other type of third‐order optical process performed on the same molecular system.
Investigating the curvilinear relationship between temporal leadership and team creativity: The moderation of knowledge complexity and the mediation of team creative process engagement
Authors: Duan Chenggang , Zhang Melody Jun , Liu Xinmei , Ling Chu‐Ding , Xie Xiao‐Yun 
Published: February 2023

SummaryModern organizations increasingly rely on teams to provide creative solutions in a timely manner. Temporal leadership has thus gained substantial interest, based on the assumption that it is conducive to team effectiveness. However, we advance a different view of temporal leadership's influence on team creativity. Building on temporal leadership literature and the paradox model of creativity, we propose that temporal leadership has a curvilinear (i.e., inverted U‐shaped) relationship with team creativity. Moreover, team knowledge complexity moderates this relationship, while team creative process engagement conditionally mediates it. We conducted two field studies to test our hypotheses. In Study 1, our analyses of multisource data from 68 research and development teams found that temporal leadership has an inverted U‐shaped relationship with team creativity, especially for teams with high knowledge complexity. In Study 2, analyses of multiwave, multisource data from 100 work teams further revealed that team creative process engagement conditionally mediates the curvilinear relationship. Specifically, temporal leadership has a stronger indirect curvilinear relationship with team creativity through team creative process engagement in teams with high (vs. low) levels of knowledge complexity. We discuss the theoretical and practical implications of these findings.
Multilayered Electrospun/Electrosprayed Polyvinylidene Fluoride+Zinc Oxide Nanofiber Mats with Enhanced Piezoelectricity
Authors: Mirjalali Sheyda , Bagherzadeh Roohollah , Abrishami Shayan , Asadnia Mohsen , Huang Shujuan , Michael Aron , Peng Shuhua , Wang Chun‐Hui , Wu Shuying 
Published: February 2023

AbstractElectrospun polyvinylidene fluoride (PVDF) nanofibers have been widely used in the fabrication of flexible piezoelectric sensors and nanogenerators, due to their excellent mechanical properties. However, their relatively low piezoelectricity is still a critical issue. Herein, a new and effective route to enhance the piezoelectricity of PVDF nanofiber mats by electrospraying zinc oxide (ZnO) nanoparticles between layers of PVDF nanofibers is demonstrated. As compared to the conventional way of dispersing ZnO nanoparticles into PVDF solution for electrospinning nanofiber mats, this approach results in multilayered PVDF+ZnO nanofiber mats with significantly increased piezoelectricity. For example, 6.2 times higher output is achieved when 100% of ZnO (relative to PVDF quantity) is electrosprayed between PVDF nanofibers. Moreover, this new method enables higher loading of ZnO without having processing challenges and the maximum peak voltage of ≈3 V is achieved, when ZnO content increases up to 150%. Additionally, it is shown that the samples with equal amount of material but consisting of different number of layers have no significant difference. This work demonstrates that the proposed multilayer design provides an alternative strategy to enhance the piezoelectricity of PVDF nanofibers, which can be readily scaled up for mass production.
Detection of ATXN2 Expansions in an Exome Dataset: An Underdiagnosed Cause of Parkinsonism
Authors: Casse Fanny , Courtin Thomas , Tesson Christelle , Ferrien Mélanie , Noël Sandrine , Fauret‐Amsellem Anne‐Laure , Gareau Thomas , Guegan Justine , Anheim Mathieu , Mariani Louise‐Laure , Le Forestier Nadine , Tranchant Christine , Corvol Jean‐Christophe , Lesage Suzanne , Brice Alexis ,   for the French Parkinson's disease genetics study group (PDG)
Published: February 2023

AbstractBackgroundCAG‐repeat expansions in Ataxin 2 (ATXN2) are known to cause spinocerebellar ataxia type 2 (SCA2), but CAA interrupted expansions may also result in autosomal dominant Parkinson's disease (AD PD). However, because of technical limitations, such expansions are not explored in whole exome sequencing (WES) data.ObjectivesTo identify ATXN2 expansions using WES data from PD cases.MethodsWe explored WES data from a cohort of 477 index cases with PD using ExpansionHunter (Illumina DRAGEN Bio‐IT Platform, San Diego, CA). Putative expansions were confirmed by combining polymerase chain reaction and fragment length analysis followed by sub‐cloning and sequencing methods.ResultsUsing ExpansionHunter, we identified three patients from two families with AD PD carrying either ATXN2 22/39 or 22/37 repeats, both interrupted by four CAA repeats.ConclusionThese findings demonstrate the usefulness of WES to detect pathogenic CAG repeat expansions, which were found in 1.7% of AD PD in the ATXN2 gene in our exome dataset.
Enteral nutrition product formulations: A review of available products and indications for use
Authors: Church April , Zoeller Steph 
Published: February 2023

AbstractWhen oral nutrition is not feasible, enteral nutrition (EN) therapy is often considered the preferred route of nutrition support to meet the nutrient needs of individuals with a functional gastrointestinal tract across multiple levels of care (critical care, acute care, and home care). Enteral formulations have progressively evolved over the last 50 years from the simple blending of hospital food thin enough to run through a feeding tube, to the development of commercial standard formulas, followed by specialized formulas with immune‐modulating and disease‐specific qualities, to the most recent shift to food‐based or blenderized EN composed of natural, whole foods with perceived health benefits. With the vast number of enteral formulations on the market, clinicians may be overwhelmed trying to determine proven vs theoretical benefits. This review is intended to explore differences in enteral formulations, identify implications for clinical practice, and review evidenced‐based clinical guidelines to assist clinicians in enteral formula selection.
Closed‐loop control of air supply to whole‐room indirect calorimeters to improve accuracy and standardize measurements during 24‐hour dynamic metabolic studies
Authors: Piaggi Paolo , Rodzevik Theresa L. , Wohlers Erica , Ruud Katherine , Moon Jon , Krakoff Jonathan , Chang Douglas C. 
Published: February 2023

AbstractObjectiveThe aim of this study was to test proportional‐integral‐derivative (PID) control of air inflow rate in a whole‐room indirect calorimeter to improve accuracy in measuring oxygen (O2) consumption () and carbon dioxide (CO2) production ().MethodsA precision gas blender infused nitrogen (N2) and CO2 into the calorimeter over 24 hours based on static and dynamic infusion profiles mimicking and patterns during resting and non‐resting conditions. Constant (60 L/min) versus time‐variant flow set by a PID controller based on the CO2 concentration was compared based on errors between measured versus expected values for respiratory exchange ratio, and metabolic rate.ResultsCompared with constant inflow, the PID controller allowed both a faster rise time and long‐term maintenance of a stable CO2 concentration inside the calorimeter, resulting in more accurate estimates (mean hourly error, PID: −0.9%, 60 L/min = −2.3%, p < 0.05) during static infusions. During dynamic infusions mimicking exercise sessions, the PID controller achieved smaller errors for (mean: −0.6% vs. −2.7%, p = 0.02) and respiratory exchange ratio (mean: 0.5% vs. −3.1%, p = 0.02) compared with constant inflow conditions, with similar (p = 0.97) and metabolic rate (p = 0.76) errors.ConclusionsPID control in a whole‐room indirect calorimeter system leads to more accurate measurements of substrate oxidation during dynamic metabolic studies.
Effect of constrained annealing on the structural and dielectric properties of melt cast PVDF/PMMA films
Authors: Jain Mayank , Mutlu Zeynep , Mao Jiahao , Zhou Jierui , Wu Chao , Cao Yang , Cakmak Mukerrem 
Published: February 2023

AbstractIn this study, the relationship between structural hierarchy in PVDF/PMMA blends as altered by melt casting and annealing and electrical properties was investigated. PVDF was blended with PMMA in three crystallizable compositions: 50/50, 60/40 and 70/30 of PVDF/PMMA using twin screw extrusion followed by film casting. The films were characterized structurally through offline birefringence measurements as well as WAXS, SAXS, IR Dichroism and DSC to understand the processing induced structural changes and their effect on electrical properties. The addition of PMMA to PVDF suppressed crystalization during casting of films. This opened a low temperature film deformation window between Tg and cold crystallization temperatures allowing for development of high preferential chain orientation in the films. Crystallinity in cast films was shown to correlate directly with breakdown strength. Systemic annealing experiments were carried out to enhance crystallinity and the effect of annealing induced structural changes on the dielectric properties were studied. It was found that upon annealing, the amorphous PMMA tends to undergo relaxation that is detrimental to the breakdown properties. As annealing progresses, the mismatch in the kinetics between crystallization/recrystallization and the amorphous relaxation causes density gradients within the bulk of the films and dictate the overall orientation levels in the films, as well as have implications on the dielectric properties.
PPE needs in the United States during the COVID‐19 pandemic: An analysis using the GetUsPPE online platform
Authors: Rubashkin Matthew , Purzycki Taylor , Coolahan Kelsey , Lee Charlotte , Lurie Daniel J , Batorsky Benjamin , Chen Alexander , Calderón Joanna , He Shuhan 
Published: February 2023

AbstractThe United States is heavily impacted by the COVID‐19 pandemic starting in 2020. Demand for personal protective equipment (PPE) domestically, along with global surge in demand for PPE during the pandemic, overwhelmed supply chains, leading to acute PPE shortages. This article analyzes the PPE supply and demand in the United States by employing data collected by GetUsPPE, a data hub used throughout the pandemic to coordinate support efforts, including connecting facilities in need of PPE with donated supplies. In this article, PPE requests were examined by facility type (acute vs. non‐acute care), geographic location, and PPE type. The research team observed that PPE demand was dispersed across the United States. In the beginning of the pandemic when demand was highest, most requesting facilities self‐reported as acute care facilities, whereas non‐acute care facilities predominated after June 2020. Additionally, the demand for respirators, disinfecting wipes, gowns, face shields, and surgical masks peaked in response to the first, second, and third waves of COVID‐19. This analysis can be utilized in the future to optimize the tracking of PPE shortages and relief efforts.
Human brain organoids to explore SARS‐CoV‐2‐induced effects on the central nervous system
Authors: Ostermann Philipp Niklas , Schaal Heiner 
Published: February 2023

AbstractSevere acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) is the causative agent of coronavirus disease 2019 (COVID‐19). In less than three years, an estimated 600 million infections with SARS‐CoV‐2 occurred worldwide, resulting in a pandemic with tremendous impact especially on economic and health sectors. Initially considered a respiratory disease, COVID‐19, along with its long‐term sequelae (long‐COVID) rather is a systemic disease. Neurological symptoms like dementia or encephalopathy were reported early during the pandemic as concomitants of the acute phase and as characteristics of long‐COVID. An excessive inflammatory immune response is hypothesized to play a major role in this context. However, direct infection of neural cells may also contribute to the neurological aspects of (long)‐COVID‐19. To mainly explore such direct effects of SARS‐CoV‐2 on the central nervous system, human brain organoids provide a useful platform. Infecting these three‐dimensional tissue cultures allows the study of viral neurotropism as well as of virus‐induced effects on single cells or even the complex cellular network within the organoid. In this review, we summarize the experimental studies that used SARS‐CoV‐2‐infected human brain organoids to unravel the complex nature of (long)‐COVID‐19‐related neurological manifestations.
SARS‐CoV‐2 nucleocapsid: Biological functions and implication for disease diagnosis and vaccine design
Authors: Maghsood Faezeh , Ghorbani Ahmad , Yadegari Hamidreza , Golsaz‐Shirazi Forough , Amiri Mohammad Mehdi , Shokri Fazel 
Published: February 2023

AbstractThe coronavirus disease 2019 (COVID‐19) pandemic is transmitted by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has affected millions of people all around the world, leading to more than 6.5 million deaths. The nucleocapsid (N) phosphoprotein plays important roles in modulating viral replication and transcription, virus‐infected cell cycle progression, apoptosis, and regulation of host innate immunity. As an immunodominant protein, N protein induces strong humoral and cellular immune responses in COVID‐19 patients, making it a key marker for studying N‐specific B cell and T cell responses and the development of diagnostic serological assays and efficient vaccines. In this review, we focus on the structural and functional features and the kinetic and epitope mapping of B cell and T cell responses against SARS‐CoV‐2 N protein to extend our understanding on the development of sensitive and specific diagnostic immunological tests and effective vaccines.
Insight on the dynamics of hydromagnetic stagnation‐point flow of magnetite‐water nanofluid due to a rotating stretchable disk: A two‐phase modified Buongiorno modeling and simulation
Authors: Sabu Alappat Sunny , Ali Farhan , Reddy Cherlacola Srinivas , Areekara Sujesh , Mathew Alphonsa 
Published: February 2023

AbstractThe hydromagnetic stagnation‐point flow of magnetite‐water nanofluid due to a rotating stretchable disk has been numerically accessed. The nanofluid flow has been modeled by employing the two‐phase modified Buongiorno model that incorporates the volume fraction dependent effective nanofluid properties, Brownian motion, and thermophoresis effects. Von Kármán's similarity transformations are utilized in transmuting the mathematically modeled equations into a system of first‐order ODEs which are then resolved numerically using the bvp4c numerical scheme. The consequence of influential parameters on the flow profiles and the physical quantities has been presented through graphs and tables. Engineering quantities like moment coefficient and pumping efficiency of the disk are also elucidated in this research work. Results show that an augmentation in the Hartmann number descends the velocity profiles and ascends the nanofluid temperature profile. Further, a drop in the drag coefficient and a rise in the heat transfer rate are noted with an increment in the velocity ratio parameter. The tidings of this numerical simulation have applications in spin coating, rotating heat exchangers, and rotating disk reactors.