bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding the non-technical skills vocabulary of operating room nurses: A qualitative study
Authors: Sirevåg Irene , Tjoflåt Ingrid , Hansen Britt Sætre 
Published: June 2023

Abstract
Background
Operating room nurses have specialised technical- and non-technical skills and are essential members of the surgical team. The profession’s dependency of tacit knowledge has made their non-technical skills inaccessible to researchers, thus, creating limitations in the identification of the non-technical skills of operating room nurses. Non-technical skills are categorised in the crew resource management framework, and previously, non-technical skills of operating room nurses have been identified within the scope of the framework. The purpose of this study is to explore operating room nurses’ descriptions of their practices in search for non-technical skills not included in the crew resource management framework.
Methods
This study has a qualitative design. An expert panel of experienced operating room nurses (N = 96) in Norway provided qualitative descriptions of their practice in a Delphi survey. This study was conducted and reported in line with Standards for Reporting Qualitative Research (SRQR).
Results
The inductive thematic analysis developed two themes, ‘Ethical caring’ and ‘Professional accountability’, that encompass operating room nurses’ novel descriptions of their non-technical skills. The participants take pride in having the patients’ best interest as their main objective even if this may threaten their position in the team.
Conclusions
This study has identified novel non-technical skills that are not described in the crew resource management framework. These findings will contribute to the development of a new behavioural marker system for the non-technical skills of operating room nurses. This system will facilitate verbalisation of tacit knowledge and contribute to an increased knowledge about the operating room nursing profession.
High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis
Authors: Hajiesmaeil Mogge , Ravasini Francesco , Risi Flavia , Magnarini Giorgia , Olivieri Anna , D’Atanasio Eugenia , Galehdari Hamid , Trombetta Beniamino , Cruciani Fulvio 
Published: June 2023

AbstractThe ampliconic region of the human Y chromosome consists of large duplicated sequences that can undergo non-allelic homologous recombination (NAHR), resulting in structural rearrangements that may cause infertility, especially when they occur in the azoospermia factor b/c (AZFb/c) region. Although AZF duplications have long been neglected due to the technical limitations of STS-based studies that focused mainly on deletions, recent next generation sequencing (NGS) technologies provided evidence for their importance in fertility. In this study, a NGS read depth approach was used to detect AZFb/c rearrangements in 87 Iranians from different ethnic groups. The duplication frequency in Iran proved to be twice as high as in the "1000 Genomes" dataset. Interestingly, most duplications were found in patrilineal ethnic groups, possibly as a consequence of their lower male effective population size which can counteract negative selection. Moreover, we found a large 8.0 Mb duplication, resulting in a fourfold increase in the copy number of AZFc genes, which to our knowledge is the largest duplication ever reported in this region. Overall, our results suggest that it is important to consider not only AZF deletions but also duplications to investigate the causes of male infertility, especially in patrilineal clan-based populations.
Fully decoupled, linear and energy-preserving GSAV difference schemes for the nonlocal coupled sine-Gordon equations in multiple dimensions
Authors: Hu Dongdong , Kong Linghua , Cai Wenjun , Wang Yushun 
Published: June 2023

Abstract
In this paper, we intend to utilize the generalized scalar auxiliary variable (GSAV) approach proposed in recent paper [SIAM J. Numer. Anal., 60 (2022), 1905-1931] for the nonlocal coupled sine-Gordon equation to construct a class of fully decoupled, linear and second-order accurate energy-preserving scheme. The unconditional unique solvability and discrete energy conservation law of the proposed scheme are rigorously discussed, and the unconditional convergence is then proved by the mathematical induction. Particularly, the convergence analysis covers the proposed scheme in multiple dimensions due to the corresponding nonlinear terms satisfy the global Lipschitz continuity straightforwardly. Finally, time evolution of dynamical behaviour of the governing equation with different nonlocal parameters are observed, and ample numerical comparisons demonstrate that the proposed scheme enjoys the high efficiency in long-time computations.
Draft Genome Sequence of a Primate Isolate of Kazachstania pintolopesii
Authors: James Steve , Parker Aimee , Purse Catherine , Telatin Andrea , Baker David , Evans Rhiannon , Holmes Sandy , Funnell Simon G. P. , Carding Simon R 
Published: June 2023

Abstract
Kazachstania pintolopesii is an opportunistic mammalian pathobiont from the K. telluris species complex. No draft genomes of this species are currently available. Here, we report the first draft genome sequence of a primate isolate of K. pintolopesii (NCYC 4417).
Land degradation vulnerability (LDV) assessment using GIS–AHP in a semi-arid, watershed in South-Central India
Authors: Chatterjee Nirmalya , Rasheed Shamla , Naikodi Praveenkumar , Vijayan Divya V. , S. Sindhu , J. Poorna Bindu 
Published: June 2023

Abstract

Land degradation vulnerability (LDV) assessment was conducted using multiple landscape, soil and vegetation parameters in an agriculturally important watershed in hot, semi-arid central peninsular region of southern India. LDV assessment in such water-stressed agricultural areas are key to understanding seasonal productivity variations, and achieving sustainable land management while intensifying agriculture to impart local food security in the current climate change regime. Multiple legacy and remotely-sensed digital datasets were used to create a land degradation vulnerability index for the Kaulasa Nala catchment using the Analytic Heirarchical Process (AHP) framework. AHP was used to balance parameter-dependance of key landscape factors during assessment of land degradation vulnerability and productivity variations. The use of expert knowledge gathered from the field during agricultural extension work improved the overall efficacy of using the AHP framework.
The analysis indicates the importance of focusing on restoration and regenerative practices in land management to improve both general land productivity at catchment scales, as well as safeguard the current productive areas from further degradation due to coupled topography-climate driven degradative processes. In this study, upland erosion vulnerability contributes to seasonal productivity changes in fertile, down slope lowland. There is a clear indication of lowland foot slopes experiencing depositional processes suffering from productivity degradation, a case of topographic and proximity-induced land quality change. Thus, our study reiterates the importance of multi-scalar and multi-parametric land degradation analysis based on field knowledge for building agricultural resilience in the semi-arid tropics.
Unlocking the Potential of Electronic Health Records Systems in Tanzania: An Assessment of their Decision-Making Capabilities in Primary Healthcare Settings
Authors: Mwogosi Augustino , Mambile Cesilia , Shao Deo , Kibusi Stephen , Kapologwe Ntuli 
Published: June 2023

Abstract
This study investigated the current state of Electronic Health Records Systems (EHRS) in primary healthcare facilities in Tanzania. The study used a cross-sectional survey to collect data from healthcare professionals working in primary healthcare facilities in Tanzania's urban and rural areas. The survey found that EHRS could be more effective in providing reminders, warnings, and alerts. The majority of respondents reported that there are no consistent reminders for medical appointments or dosage warnings. EHRS vendors are urged to prioritize developing advanced clinical decision support features in their systems to improve patient outcomes. There is also a need to address the gaps in EHRS capabilities to enable better use of order sets in primary healthcare settings. This study provides valuable insights into the capabilities of EHRS in the Tanzanian context and can inform decision-making regarding the implementation and utilization of EHRS in other developing countries facing similar challenges. Ultimately, this study can enhance healthcare delivery and improve patient outcomes in Tanzania and other developing countries. The study had limitations, including a small sample size, limited stakeholder involvement, a cross-sectional survey design, and a focus solely on EHRS decision-making capabilities. However, the findings of this study are still valuable and can be used to improve the implementation of EHRS in Tanzania and other developing countries. The study's findings suggest that there is a need for EHRS vendors to prioritize the development of advanced clinical decision support features in their systems. There is also a need to address the gaps in EHRS capabilities to enable better use of order sets in primary healthcare settings. By addressing these challenges, EHRS can be used to improve the quality of care and patient outcomes in Tanzania and other developing countries.
ATR-FT-MIR Based Inline Analysis for Determination of Phytate in Plant Residuals During Wet-Treatment
Authors: Widderich Niklas , Bubenheim Paul , Liese Andreas 
Published: June 2023

Abstract
The availability of organically bound phosphorus (P) as phytate in plant-based feeding material is a challenge for livestock farming due to limited utilization during the digestion by the animal. Another issue is the following output into the environment as manure, due to increasing restrictions for nitrogen and phosphorus. As a solution, enzymes such as phytases are added in livestock farming to increase digestibility. However, the activation of intrinsic enzymes by wet-treatment of feeding material can also effectively reduce phytate content and can be applied prior to feeding. In this study, we report on a non-invasive method based on Attenuated Total Reflection Fourier Mid-Infrared Spectroscopy (ATR-FT-MIR) and chemometrics for rapid quantification of residual phytate content during rye bran treatment; rye bran is used as an example for a plant-based feeding material. For model calibration, KH2PO4 was used as the internal standard, as phytate and its hydrolytic product ortho-phosphate experienced similar mid-infrared absorbance pattern. The residual phytate content after different treatment times was determined by applying a mass balance for P. The developed inline analysis is compared to standard offline analytical methods resulting in a RMSE of 6.2 mgphytate·100gbran-1. Thus, the developed method shows high accuracy and holds the potential for further applications for the screening and investigation of feed material conditioning prior to feeding.
An investigation into the influence of leaf species on the growth performance and oviposition preference of Aedes albopictus (Asian tiger mosquitoes) in Sri Lanka.
Authors: Nayakarathna Gayathri , Gunathilaka Kasun , Ganehiarachchi Mangala 
Published: June 2023

Abstract

Aedes albopictus is a container breeder which utilizes a wide range of water-holding containers for oviposition. The attraction of the gravid females to the oviposition site is based on several physical, chemical, and biological cues. Hence the primary objective of the study was to determine the individual and combined effects of Swietenia macrophylla, Pterospermum suberifolium, Carallia brachiata, and Azadirachta indica on the oviposition preference, larval mortality, larval duration, pupal duration and fecundity of Ae. albopictus. Microcosms were prepared with senescent leaves of the selected plant species and they were used for the tests. Accordingly, the number of eggs laid in A. indica leaf infusion was the lowest, while C. brachiata and P. suberifolium were the highest. Furthermore, the highest larval mortality, larval and pupal duration and lowest fecundity of the emerged adults were observed in A. indica. The leaf combination A. indica - C. brachiata (ND) showed the highest larval mortality and the lowest fecundity of the emerged adults, while the leaf combination S. macrophylla - A. indica - P. suberifolium (MNW) showed the highest larval and pupal durations. However, it can be postulated that A. indica leaf species hinders the growth performance and oviposition preference of Ae. albopictus.
Erich Arch Bars vs Intermaxillary Fixation Screws for Mandibular Fracture Reduction during ORIF: A Randomized Clinical Trial
Authors: Fernandes Ighor Andrade , Al-Moraissi Essam , Galvão Endi Lanza , Falci Saulo 
Published: June 2023

Abstract
Objective
This randomized clinical trial aimed to compare the efficacy of Erich Arch Bars (EAB) and Intermaxillary Fixation (IMF) Screws in reducing mandibular fractures during Open Reduction and Internal Fixation (ORIF).
Material and Methods
A total of 28 patients with mandibular fractures were randomly allocated to either the EAB group or the IMF screws group. The study evaluated various parameters including occlusal stability, complications duration of application, oral hygiene status, quality of life, and patient characteristics.
Results
The study found no significant differences in occlusal stability between the EAB and IMF screws groups. However, the application and removal times were longer for EAB compared to IMF screws. The EAB group showed a higher presence of biofilm on teeth, indicating poorer oral hygiene status compared to the IMF screws group. In terms of quality of life, patients in the EAB group reported worse results in the "handicap" domain at the 15th postoperative day. No significant differences were observed in other quality of life parameters. Patient characteristics were well-distributed between the two groups, enhancing the reliability of the results.
Conclusion
Both EAB and IMF screws demonstrated comparable occlusal stability for minimally displaced mandibular fractures. However, IMF screws offered advantages such as shorter application and removal times, better oral hygiene maintenance, and potentially improved quality of life in the "handicap" domain. Further studies with larger sample sizes are necessary to validate these findings and explore the stability of IMF methods in cases requiring postoperative malocclusion correction or prolonged IMF.
Clinical relevance:
When treating patients with minimally displaced mandibular fractures, both Erich Arch Bars (EAB) and Intermaxillary Fixation (IMF) screws can be considered as viable treatment options due to comparable occlusal stability outcomes. Clinicians can choose either method based on factors such as surgical preference and patient-specific considerations.
A Modified Deep Semantic Segmentation Model for Analysis of Whole Slide Skin Images
Authors: Asaf Muhammad Zeeshan , Rasul Hamid , Akram Muhammad Usman , Hina Tazeen , Rashid Tayyab , Shaukat Arslan 
Published: June 2023

Abstract
Automated segmentation of biomedical image has been recognized as an important step in computer-aided diagnosis systems for early detection of abnormalities. Despite its importance, the segmentation process remains an open challenge due to the indistinguishably of color, texture, shape diversity and boundaries. Semantic segmentation often requires deeper neural networks to achieve higher accuracy, making the segmentation model more complex and slower. Due to the need to process a large number of biomedical images, more efficient and cheaper image processing techniques for accurate segmentation are needed. In this article, we present a modified deep semantic segmentation model that utilizes the backbone of EfficientNetB3 along with UNet for reliable segmentation. To lighten the network, we use a balanced approach for the depth and width, and 10x magnification images are used from the Queensland dataset. We train our model to divide the image in 12 different classes for segmentation. Our method outperforms the existing literature with an increase in average class accuracy from 79\% to 83\%. Our approach also shows an increase in overall accuracy from 85\% to 94\%.
Self-removal of Catheter after Robot-Assisted Radical Prostatectomy – A Feasibility Study
Authors: Chedid Wissam Abou , Carbin Danny Darlington , Innes Maria , Casson Helen , Broe Mark , Hossain Mohammad , Fragkoulis Gerasimos , Whiting Danielle , Adamou Constantinos , Kusuma Murthy , Moschonas Dimitrios , Hicks James , Patil Krishna , Eden Christopher , Perry Matthew James Alexander 
Published: June 2023

Abstract
Objectives
Self-removal of urinary catheter as an option after Robot-Assisted Radical Prostatectomy (RARP) has never been explored in literature. We report the feasibility and outcome of the first study of this novel concept in our hospital.
Patients and Methods
We conducted a prospective audit of self-TWOC (trial without catheter) in men who underwent consecutive RARP in our centre between April 2022 and September 2022. Men who had self-TWOC filled a questionnaire about the outcomes of self-TWOC. Carbon footprint and carbon offset for each hospital TWOC avoided were calculated.
Results
Of the 129 who underwent self-TWOC, 112 filled the questionnaire and were hence included in the final analysis. Self-TWOC was successful in all the 112 (100%) men in the study. 99.1% of men were satisfied with self-TWOC at home. We managed to avoid 79.6+/-36.72 km of travel and 77 minutes of travel time for every self-TWOC. This also saved 85£/patient on clinic expenses and fuel cost savings of 9.87 to 15.99£ per patient depending on car engine size/type. The carbon footprint calculated was 20 Kilograms CO2 assuming average engine sized diesel/petrol cars and 10 Kilograms CO2 for average UK petrol hybrid car. The calculated carbon offset per patient for diesel/petrol cars: 0.32£, petrol hybrid: 0.16£. Self-TWOC for 80–160 patients will save the carbon emissions equivalent to that of a passenger on a London-New York Trans-Atlantic flight.
Conclusion
Self-TWOC is safe, affordable and is sustainable to the environment. Widespread acceptance of this practice change will be a small but steady step towards greener health systems across the world.
IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
Authors: Yuan Shyng-Shiou F. , Wang Yun-Ming , Chan Leong-Perng , Hung Amos C. , Nguyen Hieu D.H. , Chen Yuk-Kwan , Hu Stephen Chu‐Sung , Lo Steven , Wang Yen Yun 
Published: June 2023

Abstract
Background
Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlying mechanisms, remains to be elucidated.
Methods
Tumor tissues from OSCC patients were assessed for protein expression by immunohistochemistry. Patient survival was evaluated by Kaplan-Meier curve analysis. Impact of differential IL-1RA expression on cultured OSCC cell lines was assessed in vitro by clonogenic survival, tumorsphere formation, soft agar colony formation, and transwell cell migration and invasion assays. Oxygen consumption rate was measured by Seahorse analyzer or multi-mode plate reader. PCR array was applied to screen human cancer stem cell-related genes, proteome array for phosphorylation status of kinases, and Western blot for protein expression in cultured cells. In vivo tumor growth was investigated by orthotopic xenograft in mice, and protein expression in xenograft tumors assessed by immunohistochemistry.
Results
Clinical analysis revealed that elevated IL-1RA expression in OSCC tumor tissues was associated with increased tumor size and cancer stage, and reduced survival in the patient group receiving adjuvant radiotherapy compared to the patient group without adjuvant radiotherapy. In vitro data supported these observations, showing that overexpression of IL-1RA increased OSCC cell growth, migration/invasion abilities, and resistance to ionizing radiation, whereas knockdown of IL-1RA had largely the opposite effects. Additionally, we identified that EGFR/JNK activation and SOX2 expression were modulated by differential IL-1RA expression downstream of mitochondrial metabolism, with application of mitochondrial complex inhibitors suppressing these pathways. Furthermore, in vivo data revealed that treatment with cisplatin or metformin - a mitochondrial complex inhibitor and conventional therapy for type 2 diabetes - reduced IL-1RA-associated xenograft tumor growth as well as EGFR/JNK activation and SOX2 expression. This inhibitory effect was further augmented by combination treatment with cisplatin and metformin.
Conclusions
The current study suggests that IL-1RA promoted OSCC malignancy through mitochondrial metabolism-mediated EGFR/JNK activation and SOX2 expression. Inhibition of this mitochondrial metabolic pathway may present a potential therapeutic strategy in OSCC.
Optimization of extraction process and estimation of flavonoids from fenugreek using green extracting deep eutectic solvents coupled with ultrasonication
Authors: Ashraf Waqas , Rehman Abdur , Hussain Arif , Karim Aiman , Sharif Hafiz Rizwan , Siddiqui Mahbuba , Zhang Lianfu 
Published: June 2023

Abstract
The extraction of flavonoids from fenugreek seeds was investigated using ultrasound-assisted deep eutectic solvents (DES). On the basis of bioactive profile, antioxidant potential and antimicrobial properties of fenugreek extracts, the most effective DES were selected after carefully analyzing the physicochemical properties of DES. The results suggested that all the six DES performed better than conventional solvent (methanol) and among DES, choline chloride-mallic acid (CCMA), choline chloride-citric acid (CCCA) and choline chloride-1,4-butanediol (CCBU) performed better under set conditions and further selected for optimization of processing conditions, including molar ratios, water required for dilution of DES, sonication power, sonication time and sonication temperature. Identification and quantification of the flavonoids present in optimized-DES extracts was carried out using HPLC-DAD. The results revealed that prominent individual flavonoid compounds were kaempferol (10.65 ± 0.49), rutin (18.33 ± 0.84) and quercetin (10.82 ± 0.59) mg/gm d.w. with recovery percentages of as 78.83%, 92.69% and 87.18% respectively. After analyzing the results of HPLC we can conclude that CCMA (DES) is a safer, greener and highly efficient extraction system for maximum and sustainable extraction of flavonoids compounds from fenugreek seeds.