bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in the skin microbiome of burn scars
Authors: Jung Yeongyun , Cui Hui Song , Joo So Young , Lee Eun Kyung , Seo Cheong Hoon , Cho Yoon Soo 
Published: May 2023

AbstractSex differences are observed in various spectrums of skin diseases, and there are differences in wound healing rate. Herein, sex differences were identified for the newly healed skin microbiome of burn patients. Fifty‐two skin samples (26 normal skin, 26 burn scars) were collected from 26 burn patients (12 male, 14 female) and microbiota analysis was performed. The correlation between skin microbiota and biomechanical properties of burn scars was also investigated. There were no significant differences in clinical characteristics between male and female patients. Considering the biomechanical properties of burn scars and normal skin around it performed before sample collection, the mean erythema level of men's normal skin was significantly higher than that of women, whereas the mean levels of melanin, transepidermal water loss and skin hydration showed no significant sex differences. The erythrocyte sedimentation rate was significantly higher in females than that in males. Alpha diversity showed no significant differences between normal skin and burn scars in the male group. However, the scar was significantly higher than that of normal skin in the female group. Microbial network analysis revealed that the male group had more complex microbial network than the female group. Additionally, in the male group, the edge density and clustering coefficient were higher in burn scars when compared to normal skin, than the female group. There were sex differences in the results of microbiome of normal skin and burn scars. Some of the altered microbiota have been correlated with the biomechanical properties of burn scars. In conclusion, sex difference in the burn scar microbiome was confirmed. These results suggest that burn treatment strategies should vary with sex.
Molecular phylogeny of Cercopidae (Hemiptera, Cercopoidea)
Authors: Crispolon Elorde S. , Soulier‐Perkins Adeline , Guilbert Eric 
Published: May 2023

AbstractWith 175 described genera and 1556 described species, Family Cercopidae is currently divided into two subfamilies: the paraphyletic Cercopinae and the monophyletic Ischnorhininae. This study, with emphasis on the family Cercopidae, is in line with the extensive work of Cryan and Svenson which is the first phylogenetic study testing the monophyly of this family and higher‐level relationships within Cercopoidea. This study includes more representative taxa from Old World regions. The results of the phylogenetic analysis based on DNA nucleotide sequence data (18S rDNA, 28S rDNA, histone 3, and cytochrome oxidase I) show that Cercopidae is not monophyletic. Three major lineages are recovered: (1) the lineage Microsargane Fowler, 1897 + Hemitriecphora Lallemand, 1949 which is the sister group to Aphrophoridae + Epipygidae, (2) most of the Old World Cercopidae appear as a monophyletic lineage that can be subdivided into two clades, and (3) the monophyletic New World Ischnorhininae, which is separated from the rest of Cercopidae and basal to the two other lineages. It is proposed that Microsargane and Hemitriecphora should be removed from Cercopidae and placed within Aphrophoridae, and only the monophyletic Old World lineage should be kept as Cercopidae sensu stricto. The two subfamilies Cercopinae and Cosmoscartinae, corresponding respectively to the monophyletic lineage groups 2 and 3, should be kept with minimal changes on the tribal level, and the subfamily Ischnorhininae should be raised to family level Ischnorhinidae stat. nov.
Mizohata–Takeuchi estimates in the plane
Authors: Shayya Bassam 
Published: May 2023

AbstractSuppose that is a smooth compact hypersurface in and is an appropriate measure on . If is the extension operator associated with , then the Mizohata–Takeuchi conjecture asserts that for all functions and weights , where the is taken over all tubes in of cross‐section 1, and . This paper investigates how far we can go in proving the Mizohata–Takeuchi conjecture in if we only take the decay properties of into consideration. As a consequence of our results, we obtain new estimates for a class of convex curves that include exponentially flat ones such as , , .
Educational needs and preferences of adult patients with acute or chronic pain: a mixed methods systematic review protocol
Authors: Bérubé Mélanie , Verret Michael , Martorella Géraldine , Gagnon Marc-Aurèle , Bourque Laurence , Déry Marie-Philippe , Hudon Anne , Singer Lesley Norris , Richard-Denis Andréane , Ouellet Simon , Côté Caroline , Gauthier Lynn , Guénette Line , Gagnon Marie-Pierre 
Published: May 2023

Objectives:
This review will aim to synthesize the available quantitative and qualitative evidence on the educational needs and preferences of adult patients with acute or chronic pain.

Introduction:
Acute and chronic pain are prevalent problems and are associated with significant individual and societal consequences. Education is a critical component of pain management. However, the impact of educational interventions on pain outcomes remains limited. The lack of patient input––what patients want to know and how they want to be informed––is one of the main issues underlying intervention design.

Inclusion criteria:
We will include qualitative, quantitative, and mixed methods studies describing the educational needs and preferences of adult patients with acute or chronic pain.

Methods:
This review will follow the JBI guidelines for mixed methods systematic reviews. We will search MEDLINE (PubMed), Embase (Ovid), PsycINFO (Ovid), CINAHL (EBSCO), the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and ProQuest Dissertations and Theses. The search strategy will commence from the year 1990 onward and there will be no language restrictions. The retrieved titles, abstracts, and full-text reports will be screened by pairs of independent reviewers. These pairs of reviewers will also independently extract data using the JBI tools for mixed methods systematic reviews. Methodological quality will be assessed using the mixed methods appraisal tool. A convergent integrated approach to synthesis and integration of the quantitative and qualitative data will be used.

Review registration:
PROSPERO CRD42022303834
Exercise stress cardiac magnetic resonance imaging in the assessment of induced cardiovascular responses in cardiac patients: a scoping review protocol
Authors: Uwase Egidie , Caru Maxime , Levesque Ariane , Dodin Philippe , Curnier Daniel , Périé Delphine 
Published: May 2023

Objective:
This scoping review will describe cardiac magnetic resonance imaging testing protocols used in combination with exercise (Ex-CMR) to assess cardiovascular responses. The review will document the advantages and limitations of these protocols in cardiac patients.

Introduction:
Ex-CMR characterizes the heart, differentiating between normal and pathological cardiac remodeling with considerable accuracy. However, there is no review detailing existing Ex-CMR protocols. This is particularly important since not all Ex-CMR protocols seem to induce enough stress to effectively characterize cardiac remodeling, hence the need for a review to report on the current evidence.

Inclusion criteria:
This review will consider studies that use Ex-CMR testing protocols to assess cardiovascular responses, revealing cardiac remodeling in patients whose age at the time of the study was ≥ 18 years.

Methods:
The review will be conducted in accordance with the JBI methodology for scoping reviews and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The following databases will be searched: PubMed, Embase, ISI Web of Science, OpenGrey, Grey Matters, and OAlster. Articles in English and French will be included and there will be no limitation set for the date of publication. Data will be extracted from papers included in the scoping review by 2 independent reviewers and will be classified in summary tables.

Key details of this review project are available in Open Science Framework:

https://osf.io/hvn75/?view_only=f6cf8fc2112e498d89c39639dbce70d1.
Blood-Flow Restriction Is Associated With More Even Pacing During High-Intensity Cycling
Authors: Smith Nathan D.W. , Abbiss Chris R. , Girard Olivier , Scott Brendan R. , Peiffer Jeremiah J. 
Published: May 2023

Purpose: This study examined the influence of blood-flow restriction (BFR) on the distribution of pace, physiological demands, and perceptual responses during self-paced cycling. Methods: On separate days, 12 endurance cyclists/triathletes were instructed to produce the greatest average power output during 8-minute self-paced cycling trials with BFR (60% arterial occlusion pressure) or without restriction (CON). Power output and cardiorespiratory variables were measured continuously. Perceived exertion, muscular discomfort, and cuff pain were recorded every 2 minutes. Results: Linear regression analysis of the power output slope was statistically significant (ie, deviated from the intercept) for CON (2.7 [3.2] W·30 s−1; P = .009) but not for BFR (−0.1 [3.1] W·30 s−1; P = .952). Absolute power output was ∼24% (12%) lower at all time points (P < .001) during BFR compared with CON. Oxygen consumption (18% [12%]; P < .001), heart rate (7% [9%]; P < .001), and perceived exertion (8% [21%]; P = .008) were reduced during BFR compared with CON, whereas muscular discomfort (25% [35%]; P = .003) was greater. Cuff pain was rated as “strong” (5.3 [1.8] au; 0–10 scale) for BFR. Conclusion: Trained cyclists adopted a more even distribution of pace when BFR was applied compared with a negative distribution during CON. By presenting a unique combination of physiological and perceptual responses, BFR is a useful tool to understand how the distribution of pace is self-regulated.
First Find of a Frozen Mummy of the Fossil Don Hare Lepus tanaiticus (Leporidae, Lagomorpha) from the Pleistocene of Yakutia
Authors: Boeskorov G. G. , Chernova O. F. , Shchelchkova M. V. 
Published: May 2023

Abstract
Until recently, only bone remains of Don hares, which went extinct in the Holocene, were known. For the first time, the mummy of an adult hare, identified as a Don hare, has made it possible to expand our understanding of this species and its morphological adaptations to living conditions in the Arctic steppes of the Pleistocene of Yakutia: large body length, short ears and feet, powerful locomotor apparatus of the hind limbs, hard hair brushes on the feet, and excellent heat-shielding properties of the fur, including the specific microstructure of the hairs.
Alkali Waters of the Ultrabasic Massif of Mount Soldatskaya, Kamchatka: Chemical and Isotopic Compositions, Mineralogy, and 14C Age of Travertines
Authors: Taran Yu. A. , Savelyev D. P. , Palyanova G. A. , Pokrovskii B. G. 
Published: May 2023

Abstract
A detailed description of alkali water springs (pH > 10) found within the ultrabasic massif of Mount Soldatskaya in the Kamchatsky Mys Peninsula in Kamchatka is presented for the first time. The chemical composition of the springs and the dependence of the ratios and concentrations of some components on pH are indicative of the fact that these waters were involved in the present-day serpentinization of ultrabasic rocks. The springs with the highest alkali levels (pH 12.3) contain dissolved hydrogen at a concentration of about 0.6 mmol/l. The isotopic composition behavior of carbonate travertines deposited from these springs (δ13C and δ18O) differs from the known trend of “meteogenic” travertines related to serpentinization of ultrabasic rocks in Oman and California. The age of travertines determined by the radiocarbon method is close to modern.
Variations in all-cause mortality, premature mortality and cause-specific mortality among persons with diabetes in Ontario, Canada
Authors: Rosella Laura C , Kornas Kathy , Negatu Ednah , Zhou Limei 
Published: May 2023

IntroductionPatients with diabetes have a higher risk of mortality compared with the general population. Large population-based studies that quantify variations in mortality risk for patients with diabetes among subgroups in the population are lacking. This study aimed to examine the sociodemographic differences in the risk of all-cause mortality, premature mortality, and cause-specific mortality in persons diagnosed with diabetes.Research design and methodsWe conducted a population-based cohort study of 1 741 098 adults diagnosed with diabetes between 1994 and 2017 in Ontario, Canada using linked population files, Canadian census, health administrative and death registry databases. We analyzed the association between sociodemographics and other covariates on all-cause mortality and premature mortality using Cox proportional hazards models. A competing risk analysis using Fine-Gray subdistribution hazards models was used to analyze cardiovascular and circular mortality, cancer mortality, respiratory mortality, and mortality from external causes of injury and poisoning.ResultsAfter full adjustment, individuals with diabetes who lived in the lowest income neighborhoods had a 26% (HR 1.26, 95% CI 1.25 to 1.27) increased hazard of all-cause mortality and 44% (HR 1.44, 95% CI 1.42 to 1.46) increased risk of premature mortality, compared with individuals with diabetes living in the highest income neighborhoods. In fully adjusted models, immigrants with diabetes had reduced risk of all-cause mortality (HR 0.46, 95% CI 0.46 to 0.47) and premature mortality (HR 0.40, 95% CI 0.40 to 0.41), compared with long-term residents with diabetes. Similar HRs associated with income and immigrant status were observed for cause-specific mortality, except for cancer mortality, where we observed attenuation in the income gradient among persons with diabetes.ConclusionsThe observed mortality variations suggest a need to address inequality gaps in diabetes care for persons with diabetes living in the lowest income areas.
Understanding birthing preferences of women in Benin City, Nigeria: a qualitative study
Authors: Eluobaju Debra , Okonofua F , Weine Stevan , Goba Gelila 
Published: May 2023

ObjectiveThe aim of this study was to explore women’s birthing preferences and the motivational and contextual factors that influence their preferences in Benin City, Nigeria, so as to better understand the low rates of healthcare facility usage during childbirth.SettingTwo primary care centres, a community health centre and a church within Benin City, Nigeria.ParticipantsWe conducted one-on-one in-depth interviews with 23 women, and six focus groups (FGDs) with 37 husbands of women who delivered, skilled birth attendants (SBAs), and traditional birth attendants (TBAs) in a semi-rural region of Benin City, Nigeria.ResultsThree themes emerged in the data: (1) women reported frequently experiencing maltreatment from SBAs in clinic settings and hearing stories of maltreatment dissuaded women from giving birth in clinics, (2) women reported that the decision of where to deliver is impacted by how they sort through a range of social, economic, cultural and environmental factors; (3) women and SBAs offered systemic and individual level solutions for increasing usage of healthcare facilities delivery, which included decreasing costs, increasing the ratio of SBAs to patients and SBAs adopting some practices of TBAs, such as providing psychosocial support to women during the perinatal period.ConclusionWomen in Benin City, Nigeria indicated that they want a birthing experience that is emotionally supportive, results in a healthy baby and is within their cultural scope. Adopting a woman-centred care approach may encourage more women to transition from prenatal care to childbirth with SBAs. Efforts should be placed on training SBAs as well as investigating how non-harmful cultural practices can be integrated into local healthcare systems.
Effectiveness of warm-up interventions on work-related musculoskeletal disorders, physical and psychosocial functions among workers: a systematic review
Authors: Larinier Nicolas , Vuillerme Nicolas , Balaguier Romain 
Published: May 2023

ObjectivesThe aim of this systematic review was to identify from published literature the available evidence regarding the effects of warm-up intervention implemented in the workplace on work -related musculoskeletal disorders (WMSDs) and physical and psychosocial functions.DesignSystematic review.Data sourcesThe following four electronic databases were searched (from inception onwards to October 2022): Cochrane Central Register of Controlled Trials (CENTRAL), PubMed (Medline), Web of Science and Physiotherapy Evidence Database (PEDro).Eligibility criteriaRandomised and non-randomised controlled studies were included in this review. Interventions should include a warm-up physical intervention in real-workplaces.Data extraction and synthesisThe primary outcomes were pain, discomfort, fatigue and physical functions. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and used the Grading of Recommendations, Assessment, Development and Evaluation evidence synthesis. To assess the risk of bias, the Cochrane ROB2 was used for randomised controlled trial (RCT) and the Risk Of Bias In Non-randomised Studies-of Interventions was used for the non-RCT studies.ResultsThree studies met the inclusion criterion, one cluster RCT and two non-RCTs. There was an important heterogeneity in the included studies principally concerning population and warm-up intervention exercises. There were important risks of bias in the four selected studies, due to blinding and confounding factors. Overall certainty of evidence was very low.ConclusionDue to the poor methodological quality of studies and conflicting results, there was no evidence supporting the use of warm-up to prevent WMSDs in the workplace. The present findings highlighted the need of good quality studies targeting the effects of warm-up intervention to prevent WMSDs.PROSPERO registration numberCRD42019137211.
Effect of the machine learning-derived Hypotension Prediction Index (HPI) combined with diagnostic guidance versus standard care on depth and duration of intraoperative and postoperative hypotension in elective cardiac surgery patients: HYPE-2 – study protocol of a randomised clinical trial
Authors: Rellum Santino R , Schuurmans Jaap , Schenk Jimmy , van der Ster Björn J P , van der Ven Ward H , Geerts Bart F , Hollmann Markus W , Cherpanath Thomas G V , Lagrand Wim K , Wynandts Paul , Paulus Frederique , Driessen Antoine H G , Terwindt Lotte E , Eberl Susanne , Hermanns Henning , Veelo Denise P , Vlaar Alexander P J 
Published: May 2023

IntroductionHypotension is common during cardiac surgery and often persists postoperatively in the intensive care unit (ICU). Still, treatment is mainly reactive, causing a delay in its management. The Hypotension Prediction Index (HPI) can predict hypotension with high accuracy. Using the HPI combined with a guidance protocol resulted in a significant reduction in the severity of hypotension in four non-cardiac surgery trials. This randomised trial aims to evaluate the effectiveness of the HPI in combination with a diagnostic guidance protocol on reducing the occurrence and severity of hypotension during coronary artery bypass grafting (CABG) surgery and subsequent ICU admission.Methods and analysisThis is a single-centre, randomised clinical trial in adult patients undergoing elective on-pump CABG surgery with a target mean arterial pressure of 65 mm Hg. One hundred and thirty patients will be randomly allocated in a 1:1 ratio to either the intervention or control group. In both groups, a HemoSphere patient monitor with embedded HPI software will be connected to the arterial line. In the intervention group, HPI values of 75 or above will initiate the diagnostic guidance protocol, both intraoperatively and postoperatively in the ICU during mechanical ventilation. In the control group, the HemoSphere patient monitor will be covered and silenced. The primary outcome is the time-weighted average of hypotension during the combined study phases.Ethics and disseminationThe medical research ethics committee and the institutional review board of the Amsterdam UMC, location AMC, the Netherlands, approved the trial protocol (NL76236.018.21). No publication restrictions apply, and the study results will be disseminated through a peer-reviewed journal.Trial registration numberThe Netherlands Trial Register (NL9449), ClinicalTrials.gov (NCT05821647).
Mom’s Good Mood: screening and management of perinatal depression within primary healthcare system in China–protocol for an effectiveness–implementation design study
Authors: Lu Mengjuan , Jiang Minmin , Gu Yue , Li Haiyan , Hou Yanyan , Yu Xiayan , Cao Yunxia , Zhu Beibei , Tao Fangbiao 
Published: May 2023

IntroductionThe management of perinatal depression (PND) is challenging in China. The Thinking Healthy Programme (THP), developed under the core theory of cognitive–behavioural therapy, is an evidence-based approach that is recommended as a psychosocial intervention for managing PND in low/middle-income countries. Sparse evidence has been generated, however, to assess the effectiveness of THP and guide its implementation in China.Methods and analysisA hybrid type II effectiveness–implementation study is ongoing in four cities in Anhui Province, China. A comprehensive online platform, Mom’s Good Mood (MGM), has been developed. Perinatal women are screened using the WeChat screening tool (ie, Edinburgh Postnatal Depression Scale embedded as metrics) in clinics. Different intensities of the intervention are delivered through the mobile application for different degrees of depression, according to the stratified care model. The THP WHO treatment manual has been tailored to be the core component of intervention. Guided by the Reach, Effectiveness, Adoption, Implementation and Maintenance framework, process evaluations will be conducted to identify the facilitators and barriers to implementation and to modify the implementation strategy; summative evaluations will be carried out to examine the effectiveness of MGM in the management of PND within the primary healthcare system in China.Ethics and disseminationEthics approval and consent for this programme were obtained from Institutional Review Boards in China: Anhui Medical University, Hefei, People’s Republic of China (20170358). Results will be submitted to relevant conferences and peer-reviewed journals.Trial registration numberChiCTR1800016844.