bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ampelopsin alleviates cognitive impairment of SAMP8 mice by inhibiting microglial polarization and NLRP3 degradation via autophagy
Authors: Zhang meng , Liu xingran , Chang jingru , Chen dandan , qian shuaiwei , kou xianjuan 
Published: January 2023

Abstract
Microglial polarization and NRLP3 inflammasome mediated inflammation response are known to be involved in the pathological procession of AD. Ampelopsin, a natural flavonoid compound from Chinese herb Ampelopsis grossedentata, has been reported to have neuroprotective functions. However, there have been no reports on whether DHM suppresses microglial polarization and NLRP3-Caspase-1 inflammasome via autophagy pathway in an Alzheimer’s disease model. We aimed to study the effects of ampelopsin on M1/M2 polarization and the mechanism to regulate anti-inflammation both in vivo and vitro models. BV2 cells were treated with LPS in the presence or absence of DHM, and SAMP8 mice were orally administered 100 or 200 mg/kg/day of DHM for 8 weeks. Our results showed that ampelopsin significantly mitigated cognitive impairment and AD-like pathological proteins（BACE1 and APP）levels in AD mice. Treatment with different dose of ampelopsin efficiently suppressed NLRP3-Caspase-1 inflammasome activation, IL-1β and IL-18 production as well as microglia activation in the hippocampus of SAMP8 mice. Mechanistically, DHM promoted the transition from M1 to M2 microglia by up-regulating SIRT1 signaling. Transmission electron microscopy results further confirmed that DHM reversed impaired autophagy in AD mice. However, CQ, as an autophagy inhibitor, not only blocked the above protective effects of DHM in vivo, but also exacerbated those pathological changes. Our findings reveals activation of autophagic induced by DHM promote M2 polarization, NLRP3 inflammasome degradation, inhibiting inflammatory response, in turn, improving cognitive function in SAMP8 mice.
Bioinformatics analysis and verification of m6A related genes based on the construction of keloid diagnostic model
Authors: Yang Ronghua , Wang Xiaoxiang , Zheng Wenlian , Chen Wentao , Gan Wenjun , Qin Xinchi , Huang Jie , Chen Xiaodong , Zhou Sitong 
Published: January 2023

Abstract
Background: Keloid is the result of abnormal hyperplasia of skin connective tissue. This study explored the relationship between m6A related genes and keloid, and provides some reference for discovering the pathogenesis and therapeutic targets of keloid.
Methods: Transcriptomic datasets (GSE44270, GSE185309) of keloid and normal skin tissues were obtained from the Gene Expression Omnibus database (GEO). The landscape of m6A gene was constructed, then the corresponding genes were verified by immunohistochemistry. Using protein-protein interaction (PPI) network analysis, hub genes were extracted for unsupervised clustering analysis, and Gene ontology (GO) enrichment analysis was carried out to check the biological process or function affected by these differentially expressed genes. Finally, immune infiltration analysis was carried out to discuss the relationship between the therapeutic potential of keloid and immune microenvironment.
Results: There were genes with different expression trends in the three types of m6A genes, especially IGF2BP3 in the reader category, which is significantly up-regulated in keloid patients. We identified 6 genes showed significant differences through PPI analysis between the two groups of keloid samples. Enrichment analysis was performed to identify the functions of these differentially expressed genes, and we found that they were related to cell division, proliferation and metabolism, and there were significant differences in immunity-related pathways. Finally, we analyzed the immune infiltration level of immune cells in keloid with single sample Gene Set Enrichment Analysis（ssGSEA）and CIBERSORT respectively.
Conclusions: We analyzed the relationship between m6A related genes and keloid through bioinformatics methods, so as to provide corresponding references for clarifying the molecular mechanism of keloid.
Comparison of modified U-shaped and inverted L-shaped medial capsulorrhaphy in hallux vulgus surgery
Authors: Wei Xiaohua , Liu Xiong , Zhang Peng , Liu Shifeng 
Published: January 2023

Abstract
Purpose: The distal soft tissue procedure is an integral component of bunion surgery to aid in hallux valgus angular (HVA) correction. There are some reports about the lateral soft tissue release, but rarely about medial capsular placation. The purpose of this study was to report a modified U-shaped medial capsulorrhaphy and compare its clinical and radiological differences with an inverted L-shaped capsulorrhaphy.
Methods: A prospective analysis and review of 78 consecutive patients was performed between January 2018 and October 2021. All patients underwent chevron osteotomy and soft tissue procedure for hallux valgus (HV), and the patients were separated into 2 groups according to the implemented medial capsule closing technique. The modified U-shaped capsulorrhaphy was implemented for patients in group A, and the L-shaped capsulorrhaphy was done for patients in group B. All patients were followed for at least a year. The preoperative and follow-up data were collected for each patient, which include patient demographics, weightbearing radiographs of the foot, the active range of motion (ROM) of first metatarsophalangeal (MTP) joint and clinical results.
Results: In total, 75 patients with 80 feet met the inclusion criteria, there were 38 cases (41 feet) in group A and 37 cases (39 feet) in group B.Comparing the degrees of HVA and intramedullary angle (IMA) at 1 year after surgery, the statistical value of IMA was insignificant (P =0.216), but a statistically significant difference in HVA was observed between the 2 groups (P= 0.017). The degrees of ROM of the first MTP joint after 1 year in group A were better than group B (P = 0.03). American Orthopaedic Foot and Ankle forefoot score (AOFAS, forefoot) was 53.37±7.66 preoperatively and 85.51±3.94 at one-year follow-up in Group A and 52.3±8 and 86.56±3.87 respectively in Group B. Significant improvement was achieved for both groups, but neither group showed any statistically significant differences (P = 0.232).
Conclusion: Compared to the inverted L-shaped capsulorrhaphy, the modified U-shaped capsulorrhaphy can provide a better ROM of the first MTP joint, and the modified U-shaped capsulorrhaphy can help maintain the normal HVA better 1 year following surgery; it could be a better choice for medial soft tissue reconstruction in HV surgery.
Interactive effects of metal and metalloids on diatom motility and protoplasmic conditions
Authors: Sangeeta Sangeeta , Pandey Lalit Kumar , Negi Sudeeksha , Gupta Mahima , Gupta Divyanshi , Kumar Abhishek , Singh Shivangi 
Published: January 2023

Abstract

Metal and metalloid contamination in the waterbodies and its undesirable effect on the residing diatom communities is a problem of global concern. In the present study, the effect of metals (Fe and Zn) and metalloids (As and Hg) was examined (for 15 days) in the motility and protoplasmic content of different live diatom genera under laboratory conditions. Under Hg treatment, the % motile frustules in the six diatom genera lies between 2–5% after one day of exposure, while under As treatment value lies between 30–80%. In contrast, under Zn treatment % motile frustules in the six diatom genera lie between 60–80% after one day of exposure, while under Fe treatment value lies between 40–80%. However, after 15 days of exposure to Hg, the % motile frustules in the six diatom genera lies between 0–3%, while under As treatment value lies between 5–20%. In contrast, under Zn treatment % of motile frustules in the six diatom genera lies between 10–40% after one day of exposure, while under Fe treatment value lies between 10–20%. Based on the above results, the toxicity trends of metals and metalloids showed the following: Hg > As > Fe > Zn. Based on correlation ship analysis, it is found that % motile frustules in different diatom genera showed an inverse relationship with the % reduction in the protoplasmic content of the live cells i.e., the higher the value of the reduction in protoplasmic content lower will be the % motile frustules in the community. Based on obtained results, we can conclude that motility in live diatoms is the highly sensitive endpoint to assess the impact of metal and metalloid contamination in the water bodies. However, in comparison to metals, diatoms are more sensitive to the metalloid’s exposure, especially for Hg. Finally, we conclude that % motile diatom frustules in the community is a highly sensitive, quick, and easy-to-assess biomonitoring tool for assessing the metal and metalloid contamination in the water bodies.
The avian diversity of Deccan/ Western Bastar Plateau, Bastar Division, Chhattisgarh
Authors: Bharos A. M. K. , Naidu Ravi , Mandavia Ameet , Bharos Akhilesh , Vishwakarma Anurag 
Published: January 2023

Abstract
This much-needed study was undertaken from January 2017 to March 2020, in which 260 species were recorded in the geographical area of Dantewada and Bijapur districts, including Indravati Tiger Reserve. The study revealed the presence of 260 avians, both resident and migratory categories. Ten threatened category species were found, Critically Endangered two species, Vulnerable two species, and Near Threatened six Species,, including Malabar Pied Hornbill reported recently after 1991. One species was found extending its distribution range. The avian species encountered were categorized by feeding habits, the number of birds were found highest as Omnivorous and most petite as Nectarivores. In Indravati Tiger Reserve, this study revealed the presence of 165 additional species, which were not mentioned previously. Interestingly, species such as Pink-headed Duck and Lesser Florican have past records but have not been recorded in recent years. Finding a juvenile of Black Baza suggests its breeding in this area. Himalayan. Vulture was found in March 2020, the first record from Chhattisgarh. The entire area is subjected to multiple threats like large-scale poaching by locals, law and order problems, Iron ore mining, new Railway tracks and Power transmission line projects and two multipurpose hydel projects envisaged on river Indravati. These need to be mitigated. Despite our attempts, there is always scope for additions to our bird list.
Healthcare Professionals’ Perception of Physical Activity Promotion for Children with Type 1 Diabetes
Authors: Giblin Susan , Dalton Niall , Scully Paul , McCaffrey Alison , Connolly Muiriosa , Neylon Orla , O'Gorman Clodagh 
Published: January 2023

Abstract
Aims
Type 1 Diabetes (T1D) is a chronic, lifelong condition. T1D incidence and prevalence rising globally. T1D management includes daily insulin regimens, blood glucose monitoring, nutrition management and physical activity (PA). PA plays a pertinent role in mitigating some of the adverse complications associated with T1D (e.g. cardiometabolic disease). Unfortunately, children with T1D often do not meet the minimum recommended requirements for sustaining a physically active lifestyle. Children with T1D face disease-specific barriers and facilitators to PA engagement. Healthcare professionals (HCP) working with children with T1D have an important role in supporting PA as a component of diabetes management. Within an Irish context, little is known about how HCPs’ perceive their role in the promotion of PA for children with T1D. Thus, the purpose of this study was to explore the knowledge, beliefs and experiences of HCPs’ provision PA education and support to parents and children with T1D.
Methods
Members (n = 16) of the multidisciplinary team working in the paediatric outpatient diabetes clinic were recruited. Participants included 6 nurses, non-consultant hospital doctors (6 SHOs, 3 registrars) and 1 dietician. Participants completed a semi-structured questionnaire to gather information about their knowledge, beliefs and experiences in providing PA education to children, adolescents and parents.
Results
The results show that HCPs do recognise the importance of PA for maintaining health and inform patients of the importance of regular PA, however, HCPs report limited confidence in providing PA education to certain sub-populations of individuals with T1D (e.g. ethnic groups, females, overweight or obese individuals and high-level athletes). Furthermore, HCPs report limited provision of information about important facets of PA that impact blood glucose regulation (e.g. intensity, duration and aerobic versus anaerobic activity).
Conclusions
Healthcare professionals recognised their role in helping children with T1D and their parents to incorporate physical activity into diabetes management and everyday life, but perceived barriers to the successful fulfilment of their role.
Corneal Biomechanics in Normal and Subclinical Keratoconus Eyes
Authors: Peyman Alireza , Sepahvand Fatemeh , Pourazizi Mohsen , Noorshargh Pegah , Forouhari Ali 
Published: January 2023

Abstract
Background
The diagnosis of keratoconus, as the most prevalent corneal ectatic disorder, at the subclinical stage gained great attention due to the increased acceptance of refractive surgeries. This study aimed to assess the pattern of the corneal biomechanical properties derived from Corneal Visualization Scheimpflug Technology (Corvis ST) and evaluate the diagnostic value of these parameters in distinguishing subclinical keratoconus (SKC) from normal eyes.
Methods
This prospective study was conducted on 73 SKC and 69 normal eyes. Subclinical keratoconus eyes were defined as corneas with no clinical evidence of keratoconus and suspicious tomographic and tomographic features. Following a complete ophthalmic examination, topographic and tomographic corneal assessment via Pentacam HR, and corneal biomechanical evaluation utilizing Corvis ST were done.
Results
Subclinical keratoconus eyes presented significantly higher Deformation Amplitude (DA) ratio, Tomographic Biomechanical Index (TBI), and Corvis Biomechanical Index (CBI) rates than the control group. Conversely, Ambrósio Relational Thickness to the Horizontal profile (ARTh), and Stiffness Parameter at the first Applanation (SPA1) showed significantly lower rates in SKC eyes. In diagnosing SKC from normal eyes, TBI (AUC: 0.858, Cut-off value: > 0.33, Youden index: 0.55), ARTh (AUC: 0.813, Cut-off value: ≤ 488.1, Youden index: 0.58), and CBI (AUC: 0.804, Cut-off value: > 0.47, Youden index: 0.49) appeared as good indicators.
Conclusions
Integrated Corvis ST parameters could be valuable in distinguishing SKC eyes from normal ones.
Conservative surgery versus colorectal resection for endometrial deposits: a systematic review and meta-analysis of surgical and long-term outcomes
Authors: O'Brien Luke , Morarasu Stefan , Morarasu Bianca , Neary Paul C , Musina Ana Maria , Velenciuc Natalia , Roata Cristian , Dimofte Mihail-Gabriel , Lunca Sorinel , Raimondo Diego , Seracchioli Renato , Casadio Paolo , Clancy Cillian 
Published: January 2023

Abstract
PURPOSE: The optimal surgical approach for removal of colorectal endometrial deposits is unclear. Shaving and discoid excision of colorectal deposits allow organ preservation but risk recurrence with associated functional issues and re-operation. Formal resection risks potential higher complications but may be associated with lower recurrence rates. This meta-analysis compares peri-operative and long-term outcomes between conservative surgery (shaving and disc excision) versus formal colorectal resection.
METHODS: The study was registered with PROSPERO. A systematic search was performed on PubMed and EMBASE databases. All comparative studies examining surgical outcomes in patients that underwent conservative surgery versus colorectal resection for rectal endometrial deposits were included. The two main groups (conservative versus resection) were compared in three main blocks of variables including group comparability, operative outcomes and long-term outcomes.
RESULTS: Seventeen studies including 2861 patients were analysed with patients subdivided by procedure: colorectal resection (n=1389), shaving (n=703) and discoid excision (n=742). When formal colorectal resection was compared to conservative surgery there was lower risk of recurrence (p=0.002), comparable functional outcomes (minor LARS, p=0.30, major LARS, p=0.54), similar rates of postoperative leaks (p=0.22), pelvic abscesses (p=0.18) and rectovaginal fistula (p=0.92). On subgroup analysis, shaving had the highest recurrence rate (p=0.0007), however a lower rate of stoma formation (p<0.00001) and rectal stenosis (p=0.01). Discoid excision and formal resection were comparable.
CONCLUSION: Colorectal resection has a significantly lower recurrence rate compared to shaving. There is no difference in complications or functional outcomes between discoid excision and formal resection and both have similar recurrence rates.
Exploring the characteristics of Pre-service EFL teachers’ practicum experiences: A complexity theory-based case study in China
Authors: Li Ming , Kuang Fangtao , Dan Wei 
Published: January 2023

Abstract
With increasing attention being paid to teacher education, various theoretical perspectives have been adopted to study on how pre-service teachers learn to teach. This study employed complexity theory as conceptual framework and examined two pre-service EFL teachers’ practicum experiences by qualitative case study and identified three core characteristics of their learning-to-teach: complexity, dynamism and self-organization. It is found that pre-service EFL teacher learning, as a complex system, interacted between and among a network of socio-contextual factors and thus influenced and being influenced during the learning process in a non-linear and complex way. This study made empirical and theoretical contributions to the research field of teacher education and provided implications for university-school collaboration-based teacher education practice.
Power in the Pipeline: Gas Centrality Reduces Leader Turnover
Authors: Gallea Quentin , Morelli Massimo , Rohner Dominic 
Published: January 2023

Abstract
This paper provides the first comprehensive empirical analysis of the role of natural gas for the domestic and international distribution of power. The crucial role of pipelines for the trade of natural gas determines a set of network effects that are absent for other natural resources. Gas rents are not limited to producers but also accrue to key players occupying central nodes in the gas network. Drawing on our new gas pipeline data, this paper shows that gas centrality of a country increases substantially the ruler's grip on power as measured by lower leader turnover. A main mechanism at work is the reluctance of connected gas trade partners to impose sanctions, meaning that bad behavior of gas-central leaders is tolerated for longer before being sanctioned. Overall, this reinforces the notion that fossil fuels are not just poison for the environment but also for political pluralism and healthy regime turnover.
The Temporal Trend of Placebo Response in Migraine Prevention from 1990 to 2021: A Systematic Literature Review and Meta-Analysis with Regression
Authors: Tepper Stewart J. , Cirillo Jessica , Kim Edward , L'Italien Gil , Tweedie Julie , Lodaya Kunal , Riley Dushon , Pathan Farah , Antaki Nicholas , Nathanson Brian H. , McAllister Peter 
Published: January 2023

Abstract
Background
Migraine affects 1.1 billion people globally and is the second leading cause of disability worldwide. In clinical trials, treatment efficacy is evaluated by comparing the differential responses in the treatment and placebo arms. Although placebo response in preventive migraine trials has been studied, there is limited research examining temporal trends. This study evaluates the trend of placebo response over thirty years in migraine prevention trials and investigates the association of potential confounders, such as patient, treatment, and study characteristics on placebo response using meta-analysis with regression.
Methods
We conducted literature searches from January 1990 to August 2021 in bibliographical databases (PubMed, Cochrane Library, and EMBASE). Studies were selected according to PICOS criteria and included randomized, double-blind, placebo-controlled trials evaluating preventive migraine treatments in adult patients diagnosed with episodic or chronic migraine, with or without aura. The protocol was registered with PROSPERO (CRD42021271732). Migraine efficacy outcomes included were either continuous (e.g., monthly migraine days) or dichotomous (e.g., ≥50% responder rate (yes/no)). We assessed the correlation of the change in outcome from baseline in the placebo arm, with the year of publication. The relationship between placebo response and year of publication was also assessed after accounting to confounders.
Results
A total of 907 studies were identified, and 83 were found eligible. For the continuous outcomes, the change from baseline in mean placebo response showed an increase over the years (rho=0.32, p=0.006). The multivariable regression analysis also showed an overall increase in placebo response over the years. The correlation analysis of dichotomous responses showed no significant linear trend between publication year and mean placebo response (rho=0.08, p=0.596). Placebo response also varied by route of administration.
Conclusion
Placebo response increased over the past 30 years in migraine preventive trials. This phenomenon should be considered when designing clinical trials and conducting meta-analyses.
The risk of persistent hypertension and chronic kidney disease in early and late-onset preeclampsia, a report from a low middle income country
Authors: Ernawati Ernawati , Sulistyono Agus , Aditiawardana Aditiawardana , Kamalia Kamalia , Rifdah Salsabila Nabilah , Akbar M. Ilham Aldika , Gumilar Erry , Aditiawarman Aditiawarman 
Published: January 2023

Abstract

Background
Early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP) are associated with different maternal and fetal outcomes, biochemical markers, and clinical characteristics. Nevertheless, only a few data were presented about its long-term effects on kidney function later in life.
Objective
This study aimed to explore the risk of persistent hypertension and kidney failure in EOP and LOP in five years after delivery. Study Design: This retrospective cohort study included women with prior history of severe preeclampsia or normotensive pregnancy admitted to one of tertiary hospitals in Indonesia. The blood pressure, body mass index, urea and creatinine serum, and protein urine were analyzed, and risk of chronic kidney disease (CKD) was performed using KDIGO classification.
Results
A total of 27 EOP, 35 LOP and 30 normotensive cases were included. Mean blood pressure after five years recorded respectively 115.6 ± 14.25 mmHg in normotensive group, 131.82 ± 19.34 mmHg in LOP group, and 154.96 ± 23.48 mmHg in EOP group. Percentage of women with positive protein urine varied from 13.3–31.4% and 66.7% in normotensive, LOP, and EOP, respectively. According to KDIGO classification, normotensive group had 90% of low-risk CKD, whereas the severe preeclampsia group had 41.9% of high-risk CKD. In the severe preeclampsia group, the risk of CKD was 20.94 times higher compared to normotensive women (OR 20.94; 95% CI [2.67-163.72], p = 0.004). Then risk of CKD in EOP group was 6.75 times higher than LOP group (OR 6.75; 95% CI [2.19–20.76], p = 0.001), whereas persistent hypertension in EOP group was 5.78 times higher than LOP group (OR 5.78; 95% CI [1.91-17.395], p = 0.002).
Conclusions
Preeclampsia women have a higher risk of CKD than normotensive women. Women with a history of EOP are more likely to develop persistent hypertension and CKD than women with prior LOP history.