bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent life events and adverse childhood experiences in predicting antenatal depression and anxiety: cross-sectional study
Authors: Zilmer Benedicte M , Overbeck Gritt , Siersma Volkert , Wilson Philip 
Published: January 2025

Abstract

Background
Antenatal depression and anxiety are associated with preterm labour, low birth weight, and postpartum depression, and can impact the emotional and mental development of the child. Both adverse childhood experiences and recent stressful events are linked to negative health outcomes. However, certain events may be more impactful than others.

Objective
This study aims to investigate the most important types of adverse childhood events and recent stressors that may help in identifying pregnant women in most need of psychological support.

Methods
This observational study examines data from the FamilieTrivsel trial, in which women between 6 and 10 weeks gestation were recruited by general practitioners. All participants were asked to complete questionnaires. Mental health was assessed with the Hospital Anxiety and Depression Score (HADS). Potential contributory risk factors were identified using the Recent Life Events Questionnaire and the Adverse Childhood Experiences questionnaire. The relative importance of the various types of events was analysed in a dominance analysis, and the direction of their association was determined by a multivariable linear regression analysis.

Results
Of specific recent life events, serious problems with a friend, divorce, racial harassment, unemployment, financial difficulties, and moving house had the strongest associations with poor mental health, along with childhood experience of mental illness in the household. Growing up with an experience of physical neglect and parental divorce were, paradoxically, associated with lower HADS scores.

Conclusions
Recent stressful life events have a stronger association with postnatal mental health than adverse childhood events, implying that it might be useful for clinicians providing routine antenatal care to gather information on recent stressors.
Association of Dementia Severity at Diagnosis with Health Care Utilization and Costs around the Time of Incident Diagnosis
Authors: Xu Shengjia , Fouladi-Nashta Niloofar , Chen Yi , Zissimopoulos Julie 
Published: January 2025

Abstract

Background and Objectives
This study provides the first analysis of heterogeneity in health care use and costs by level of dementia symptom severity around the time of incident dementia diagnosis for a population representative sample of older Americans.

Research Design and Methods
We used the Aging, Demographics, and Memory Study (ADAMS), the Health Retirement Study (HRS), and traditional Medicare (TM) claims. We modeled dementia severity measured by the Clinical Dementia Rating Scale for ADAMS respondents and applied parameter estimates to HRS respondents older than 70 years who had a claims-based incident dementia diagnosis in 2000-2016. We used claims-based measures of health care costs and use and quantified levels in the quarters before, at, and after a dementia diagnosis. We reported separate results for groups of persons diagnosed at mild, moderate, and severe stages of dementia.

Results
Health care use and costs increased a quarter before dementia diagnosis and increased most significantly in the quarter of diagnosis. Both use and costs declined thereafter but remained elevated relative to pre-diagnosis. This general pattern was consistent for persons diagnosed at different stages of dementia. Acute care costs were similar across dementia severity categories throughout the period while outpatient use and costs were consistently higher among persons diagnosed at mild stage disease.

Discussion and Implications
Findings from this study provide new insights on how heterogeneity of dementia severity at diagnosis is associated with health care use and costs. Under the current system of care in TM, early dementia diagnosis may not substantially reduce health care use and spending around the time of dementia diagnosis.
How has the concept of health system software been used in health policy and systems research? A scoping review
Authors: Burger Nicola , Gilson Lucy 
Published: January 2025

Abstract
Understanding health systems as comprising interacting elements of hardware and software acknowledges health systems as complex adaptive systems (CASs). Hardware represents the concrete components of systems, whereas software represents the elements that influence actions and underpin relationships, such as processes, values, and norms. As a specific call for research on health system software was made in 2011, we conducted a qualitative scoping review considering how and for what purpose the concept has been used since then. Our overall purpose was to synthesize current knowledge and generate lessons about how to deepen research on, and understanding of, health system software. The review consisted of two phases: first, for the period 2011–23, all papers that explicitly used the concept of health system software were identified and mapped; second, drawing on a subset of papers from Phase 1, we explored how the concept was purposively used within research. The databases PubMed, Scopus, EBSCOhost, Web of Science, and Google Scholar were systematically searched using a strategy developed by a skilled librarian. In Phase 1, data were extracted from 98 papers. Our analysis revealed that a third of the papers used the software concept rather superficially; a third used it to conceptualize the importance of selected software elements; and a third used it in examining a specific health system experience, such as preparedness or resilience. In Phase 2, our analysis confirmed that researchers have found value in proactively using the software concept within studies, demonstrating two patterns of use. However, a limited understanding of how to investigate interactions among hardware and software elements was also revealed. Future health policy and systems research should purposively investigate hardware–software interactions in order to gain a greater understanding of the complex, adaptive nature of health systems, understand their operations, and institutionalize thinking that considers health systems as CASs.
Evaluating the type 2 fuzzy logic controller with multilayer perceptrons for optimal tracking of solar photovoltaic systems
Authors: Rinesh S , Arun M , Kumar S N , Prajitha C , Kumar A P Senthil 
Published: January 2025

Abstract
This study proposes the type 2 fuzzy logic controller with genetic algorithm (T2FLC-GA) for optimal tracking of solar photovoltaic (PV) systems. The suggested technique improves the high-power transmission to loads under long-term weather conditions. Genetic algorithms (GAs) are search algorithms that use natural selection and genetic mechanisms to simultaneously find the near-optimal design for control rules and membership functions. The research proposes a control system that uses GA to increase a PV system’s output energy. This system adjusts the spatial angles of the solar panels along the vertical and horizontal axes. The numerical findings illustrate that the suggested T2FLC-GA model increases the accuracy rate of 98.5%, solar tracking rate of 96.5%, overall performance rate of 97.6%, computation cost rate of 10.5%, and power generation rate of 94.5% compared to other existing models.
Self-orbit Equivalences on a Class of Anosov Flows
Authors: Yu Bin 
Published: January 2025

Abstract
Let $M_{k}$ ($k\in{{\mathbb{Z}}}$ and $|k|&gt;4$) be the $3$-manifold obtained by doing $k$ Dehn surgery on the figure-eight knot, and $X_{t}$ be the canonical Anosov flow on $M_{k}$ that is constructed by Goodman. The main result of this article is that if $|k|\gg 0$, then $\mbox{Mod} (M_{k}) \cong{{\mathbb{Z}}}_{2}\oplus{{\mathbb{Z}}}_{2}$ and every element of the mapping class group of $M_{k}$ can be represented by a self orbit equivalence of $X_{t}$.
Mpox: What Have We Learned and How Do We Better Prepare for the Future?
Authors: Judson Seth D , Orkin Chloe M , Gebo Kelly 
Published: January 2025

Abstract
The global outbreak of clade IIb mpox in 2022–2023 changed our understanding of the epidemiology and prevention of mpox, simultaneously highlighting inequities in access to vaccines, diagnostics, and therapeutics. With the recent multinational spread of clade Ib mpox, it is important to revisit these lessons to improve future response. In September 2024, an international mpox symposium was held at Johns Hopkins University to discuss what we have learned and how to better prepare for the future. Here we highlight perspectives from that meeting and priorities for future mpox research.
Global trends and projections of high BMI burden and its independent impact on atrial fibrillation and flutter
Authors: He YuBin , Ren YaPing , Zhang YaYun , Zhu Zixiong , Li Xuewen 
Published: January 2025

Abstract

Background
This study evaluates changes in the burden of high body mass index (BMI) and its impact on atrial fibrillation and flutter (AF/AFL) using the 2021 Global Burden of Disease database.

Methods
Mortality and disability-adjusted life years rates were analysed globally, considering age, sex, geography and the Socio-demographic Index (SDI). Decomposition and frontier analyses assessed the impact of epidemiological drivers and SDI on the burden. The nordpred model validated the predictions.

Results
The burden of high BMI is now 2.5 times greater than 30 y ago and will continue to increase over the next 20 y, heavily impacting cardiovascular and metabolic diseases. High BMI–related AF/AFL also poses a significant burden, especially in developed regions. Men's burden grows faster than women's. Decomposition analysis shows epidemiological changes mainly drive burden increases, while in women, population growth is more significant. Frontier analysis indicates that the gap between actual burden and theoretical optimal value has widened with increasing SDI, except in countries such as Bulgaria and the Czech Republic.

Conclusions
Over the past 30 y, the overall burden of high BMI and its impact on AF/AFL have increased significantly, highlighting the need for targeted public health strategies.
Walnut PR10/Bet v1-like proteins interact with chitinase in response to anthracnose stress
Authors: Wang Tianyu , Xie Muhong , Hou Siyu , Ma Jiyan , Lin Yeli , Chen Sisi , Li Dapei , Yang Guiyan 
Published: January 2025

Abstract
Walnut is a significant woody oil tree species that has been increasingly affected by anthracnose in recent years. Effective anthracnose control is crucial for walnut yield and quality, which requires a comprehensive understanding of the response mechanisms to Colletotrichum gloeosporioides. The PR10/Bet v1-like proteins are involved in defense against various diseases, therefore, in this study, seven JrBet v1s were identified from the walnut transcriptome (named JrBet v1-1~1-7), whose open reading frame was 414~483 bp in length with isoelectric point ranging from 4.96 to 6.11. These JrBet v1s were classified into three groups, with the MLP/RRP and Dicot PR-10 subfamilies each comprising three members (the largest ones), indicating that the proteins within these two subfamilies may have evolved from a shared ancestral gene within the broader PR10/Bet v1 protein family. The cis-elements in the promoters of JrBet v1s were involved in response to hormones, coercive, and plant growth metabolism. Most JrBet v1s could be significantly upregulated by walnut anthracnose, JrBet v1-1, JrBet v1-2, JrBet v1-4, and JrBet v1-6 peaked at 12 days of anthracnose stress, showing a 2.85- to 63.12-fold increase compared to the control, while JrBet v1-3, JrBet v1-5 and JrBet v1-7 peaked at 9 days, with a 3.23- to 27.67-fold increase. Furthermore, the significant correlation of the upregulation under anthracnose stress of JrBet v1s and JrChit02-1 as well as JrChit02-2, the genes encoding chitinase, suggesting that during the long process of microevolution in walnut-C. gloeosporioides interactions, walnut has developed a Bet v1-chitinase defense mechanism to counteract pathogen invasion.
Parental loss at age 0-21 and daughters' breast cancer and tumor characteristics
Authors: Keeler Corinna , Krigbaum Nickilou Y , Cohn Barbara , Cirillo Piera 
Published: January 2025

Abstract

Background
Adverse events in childhood are linked to cancer risk across the life course, but evidence is lacking regarding parental death during childhood and breast cancer (BrCa) characteristics. We investigated whether parental loss in childhood defines women at higher risk of BrCa incidence and aggressive disease.

Methods
The Child Health and Development Studies (CHDS) comprises over 15,000 families who enrolled during mothers’ pregnancies between 1959-1967; family members were followed for cancer incidence and cause-specific mortality. We constructed an analytical cohort of all live-born CHDS daughters (N = 9,169), linked to their parents’ cause and date of death. We estimated adjusted hazard ratios of incident BrCa, stage at diagnosis, and tumor hormone receptor expression for parental loss in Cox models adjusted for race, maternal BrCa, and paternal age. Generalized linear models estimated associations between breast density and parental loss among a subsample CHDS daughters (N = 610) with available mammography.

Results
137 CHDS daughters were diagnosed with BrCa by age 52, and 654 daughters lost one or both parents at age ≤21. Loss of both parents was associated with BrCa incidence [aHR(95%CI)=4.69(1.68,13.04)], late-stage at diagnosis [aHR(95%CI)=9.47(1.38,64.84)], and HER2-positive, PR-negative, and ER-negative tumors. Loss of mother or father was associated with HER2-positive tumors. Breast density in the premenopause window was associated with loss of mother or both parents.

Conclusion
Death of one or both parents during childhood was strongly associated with BrCa and aggressive disease. Parental death during childhood could be added to medical histories to indicate counseling regarding prevention and early detection of BrCa.
A design-based view of species richness estimation in environmental surveys
Authors: Di Biase Rosa M , Fattorini Lorenzo , Marcelli Agnese 
Published: January 2025

Abstract
In this work, the estimation of species richness is approached from a design-based perspective, considering the probabilistic sampling of species and checking the performance of the estimators automated in the SPADE software. As shown theoretically and by a simulation study, these estimators are affected by a massive negative bias. To reduce the underestimation of species richness, data integration is attempted, by exploiting the list of rare species compiled by purposive surveys. Richness estimation is then performed on the residual community of species not in the list, and a bootstrap mean squared error estimator is applied. A simulation study and the application to four case studies produce encouraging results.
Rare Case of Immediate Postoperative Acute Gout Flare Associated With Surgical Management of Facial Abscess of Odontogenic Origin—Case Report
Authors: Vargas Nikoletta , Saraghi Mana 
Published: January 2025

ABSTRACT
Gout is caused by monosodium urate crystal deposition within joints and periarticular structures. It is characterized by the typical arthritis symptoms such as pain, swelling, and redness usually involving the first metatarsophalangeal joint. Recurrent attacks of gout are common, especially after major surgical procedures during which intense cell turnover takes place and can lead to hyperuricemia and accumulation of monosodium urate crystals. However, there is insufficient evidence about the re-occurrence of gout in patients after surgical interventions in the head and neck area. This case report is the first to describe an immediate acute gout episode after surgical management of a facial abscess involving multiple spaces, associated with severely decayed, nonrestorable lower left molars, in a 58-year-old male patient with a history of gout. It furthermore describes prophylactic measures to prevent the occurrence of gout flares in similar cases.
Thermal stresses as a possible mechanism for initiating the destruction of comet Shoemaker–Levy 9
Authors: Shestakova Lyubov I , Spassyuk Ruslan , Omarov Chingis 
Published: January 2025

ABSTRACT
It is now widely accepted that the breakup of comet Shoemaker–Levy 9 (SL9) was caused by tidal forces. This explanation applies to bodies that enter a planet’s Roche zone and have a loose ‘rubble pile’ structure with no internal strength. Observations from the Rosetta mission to comet 67P/Churyumov–Gerasimenko initially supported this hypothesis, as the comet’s surface strength was exceptionally low. However, beneath this loosely bound surface layer, a dense mixture of ice and rock was detected, as evidenced by deep cracks. Similar fractures on Mars yielded strength estimates of around 2 MPa. In this paper, we hypothesize the observed fragmentation pattern of comet SL9 caused by preliminary fracturing due to internal stresses. We calculate the internal thermal stresses using the analytical solution of the heat diffusion equation for bodies approaching the Sun along parabolic trajectories. The results indicate that upon reaching Jupiter’s orbit, thermal stresses develop within bodies composed of crystalline ice with radii ranging from 60 m to 5 km, exceeding the material’s tensile strength. When the tidal forces subsequently separated the fragments, they formed a chain of large bodies, with the central body corresponding to the inner core of the comet. The fragments closest to the surface were observed before and behind the central core. Therefore, the preliminary fracturing of the comet by thermal stresses, followed by the separation of resulting fragments due to tidal forces, appears quite plausible.
Characteristics of patients with polymyalgia rheumatica based on glucocorticoid dose in Japan: A cohort study using routinely collected health data
Authors: Tanaka Yoshiya , Takahashi Toshiya , Inokuchi Shoichiro , Uenaka Hidetoshi , Fujita Akiko , Sakamoto Kazuhito 
Published: January 2025

Abstract

Objectives
This study aimed to describe the characteristics, inflammatory markers as surrogates for disease activity, and treatment of patients with polymyalgia rheumatica (PMR) in Japan.

Methods
This cohort study analysed the data of 373 patients with PMR retrieved from an electronic medical records database in Japan. Patients were classified into quartiles, based on the daily glucocorticoid dose over the initial 90 days of treatment (Q1–Q4).

Results
The low glucocorticoid dose group (Q1) had more patients aged ≥90 years (11.7%), and a higher prevalence of comorbidities. At 52 weeks, glucocorticoid-free remission was achieved in 10% of patients, and higher C-reactive protein levels were observed during the follow-up period. In contrast, the high glucocorticoid dose group (Q4) exhibited a slower decline in C-reactive protein levels and more events of increased glucocorticoid dose compared to Q1–Q3. The introduction of methotrexate was low, with 4.3% to 7.3% of patients. The incidence of osteoporosis and diabetes was higher in patients &lt;75 years, whereas the incidence of hypertension was higher in patients ≥75 years.

Conclusions
Patients refractory to high glucocorticoid doses were identified. Patients receiving inadequately low doses of glucocorticoids were older with more comorbidities. This study highlights the unmet medical needs for PMR.
“What is this brain’s story?” Healthcare professionals’ perspectives on managing brain tumor-related personality and behavior changes
Authors: McDougall Emma , Nowak Anna K , Dhillon Haryana M , Breen Lauren J , Piil Karin , Halkett Georgia K B 
Published: January 2025

Abstract

Background
Managing brain tumor-related personality and behavior changes (BTrPBc) is complex with contributors including tumor location, type, and grade; treatment side effects; and psychological adjustment to a primary brain tumor diagnosis. Although carers of people with high-grade glioma consistently report BTrPBc as an area where they require support, there is a lack of guidelines for healthcare professionals to address BTrPBc. We aimed to explore how neuro-oncology healthcare professionals manage personality and behavior changes in adults with a primary brain tumor.

Methods
This study used an interpretive description approach. Semi-structured interviews were conducted with healthcare professionals practicing in neuro-oncology across Australia via face-to-face, telephone, and video conference. Codebook thematic analysis methods were used.

Results
Healthcare professionals (N = 22) from a range of medical and allied health disciplines participated in interviews with an average duration of 34 minutes. Four themes described how healthcare professionals seek to manage patients’ personality and behavior changes: (i) Building trusting relationships, (ii) What is this brain’s story?, (iii) Brief intervention; and (iv) Targeted intervention. Sub-themes were developed within each theme.

Conclusions
Our results highlight the diverse support healthcare professionals provide for the management of BTrPBc. There is a need for interventions to be formulation-driven, involve individualized care, provide education, and focus on the patient-carer dyad. A stepped-care approach to managing BTrPBc is recommended; however, further evaluation in clinical practice is necessary.
PROCERA interacts with JACKDAW in gibberellin-enhanced source–sink sucrose partitioning in tomato
Authors: Liang Yufei , Zhao Jingyi , Yang Rui , Bai Jiayu , Hu Wanxing , Gu Lixia , Lian Zhaoyuan , Huo Heqiang , Guo Jia , Gong Haijun 
Published: January 2025

Abstract
Proper regulation of the source–sink relationship is an effective way to increase crop yield. Gibberellin (GA) is an important regulator of plant growth and development, and physiological evidence has demonstrated that GA can promote source–sink sucrose partitioning. However, the underlying molecular mechanism remains unclear. Here, we used a combination of physiological and molecular approaches to identify the components involved in GA-enhanced source–sink sucrose partitioning in tomato (Solanum lycopersicum). GA treatment increased the sucrose export rate from source leaves and the sucrose level in young leaves (sink organ). GA-mediated enhancement of source–sink sucrose partitioning depended on SlPROCERA (SlPRO), the DELLA protein in tomato. Sucrose transporter 1 (SlSUT1) was involved in phloem sucrose loading. SlJACKDAW (SlJKD) was identified as an interaction partner of SlPRO. SlJKD negatively regulated the sucrose export rate from source leaves and could directly bind to the promoter of SlSUT1 and repress its expression, while SlPRO enhanced the transcription repression function of SlJKD. This study reveals the molecular mechanism by which GA promotes source–sink sucrose partitioning in tomato and provides potential targets for source–sink relationship optimization.
Doctor Donne’s Magical Sermon
Authors: Schrock Chad 
Published: January 2025

Abstract
John Donne fantasized about a single affective experience, infinitely dense and rich, that opened directly onto transcendence. In his 1622/3 Lenten sermon on John 11:35, ‘Jesus wept’, he finally described one that worked perfectly. Jesus’s sorrow over Lazarus’s death opened a stream of tears that ran into a river that ran into an infinite sea of sorrow at how sin has ravaged all created existence. Unlike Jesus, the rest of us either burn hot and dry with immoderate passions or, more disastrously, are dead to passion entirely. To get us to feel properly, Donne must use ‘contrary musique to charme … contrary physick to cure’ (327) the hot, cold, salamandrine, serpentine dead. He offers the affective power of his sermon as the sacramental means appropriate to this necessarily enchanted grace. Through exposition of the holy text, through the incantatory power of his homiletic performance, and through the mysterious application of the Holy Spirit, Donne invites his audience to cry Christ’s tears through their eyes so that they may experience how Christ feels perfectly: a contrary music, a dissonant melody in which holy sorrow and holy joy are not only indistinguishable but the same.