bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Role of the Sr3−xCaxAl2O6 Sacrificial Layer Composition in Epitaxial La0.7Sr0.3MnO3 Membranes
Authors: Salles Pol , Guzman Roger , Barrera Aleix , Ramis Martí , Caicedo Jose Manuel , Palau Anna , Zhou Wu , Coll Mariona 
Published: June 2023

AbstractThe possibility to fabricate freestanding single crystal complex oxide films has raised enormous interest to be integrated in next‐generation electronic devices envisaging distinct and novel properties that can deliver unprecedented performance improvement compared to traditional semiconductors. The use of the water‐soluble Sr3Al2O6 (SAO) sacrificial layer to detach the complex oxide film from the growth substrate has significantly expanded the complex oxide perovskite membranes library. Nonetheless, the extreme water sensitivity of SAO hinders its manipulation in ambient conditions and restricts the deposition approaches to those using high vacuum. This study presents a pioneering study on the role of Ca‐substitution in solution processed SAO (Sr3−xCaxAl2O6 with x ⩽ 3) identifying a noticeable improvement on surface film crystallinity preserving a smooth surface morphology while favoring the manipulation in a less‐restricted ambient conditions. Then, the study focuses on the effect of the sacrificial composition on the subsequent ex situ deposition of La0.7Sr0.3MnO3 (LSMO) by pulsed laser deposition, to obtain epitaxial films with a variable degree of strain. Finally, epitaxial and strain‐free LSMO membranes with metal‐insulator transition at 290 K are delivered. This study offers a hybrid and versatile approach to prepare and easily manipulate crystalline perovskite oxide membranes by facilitating ex situ growth on SAO‐based sacrificial layer.
Multisite Synergism‐Induced Electron Regulation of High‐Entropy Alloy Metallene for Boosting Alkaline Hydrogen Evolution Reaction
Authors: Mao Qiqi , Mu Xu , Deng Kai , Yu Hongjie , Wang Ziqiang , Xu You , Li Xiaonian , Wang Liang , Wang Hongjing 
Published: June 2023

AbstractDesigning the high‐entropy alloys (HEAs) electrocatalysts with controllable nanostructures is of great significance for the development of efficient alkaline hydrogen evolution reaction (HER) electrocatalysts. In this study, an ultrathin HEA‐PdPtRhIrCu metallene with abundant lattice distortions and defects is prepared via a facile one‐step hydrothermal method. The synthesized HEA‐PdPtRhIrCu metallene exhibits superior HER performance in a 1 m KOH solution, where the required overpotential of HEA‐PdPtRhIrCu metallene is only 15 mV to reach a current density of −10 mA cm−2 while possessing a low Tafel slope for 37 mV dec−1. Density functional theory calculations further prove that the synergistic effect of the five elements can optimize the electronic structure to enhance the HER activity of the catalysts. In particular, the strong coupling effect and the strong bonding arising from the interaction between the multi‐metal components can facilitate the electron transfer of the surface and high electroactivity. Moreover, the optimized Pt electronic structure in HEA‐PdPtRhIrCu metallene promotes the optimal PtH binding at the Pt site, thus promoting HER performance.
Rational Design and Efficacy of Glucose‐Responsive Insulin Therapeutics and Insulin Delivery Systems by Computation Using Connected Human and Rodent Models
Authors: Yang Sungyun , Yang Jing Fan , Gong Xun , Weiss Michael A. , Strano Michael S. 
Published: June 2023

AbstractGlucose‐responsive insulins (GRIs) use plasma glucose levels in a diabetic patient to activate a specifically designed insulin analogue to a more potent state in real time. Alternatively, some GRI concepts use glucose‐mediated release or injection of insulin into the bloodstream. GRIs hold promise to exhibit much improved pharmacological control of the plasma glucose concentration, particularly for the problem of therapeutically induced hypoglycemia. Several innovative GRI schemes are introduced into the literature, but there remains a dearth of quantitative analysis to aid the development and optimization of these constructs into effective therapeutics. This work evaluates several classes of GRIs that are proposed using a pharmacokinetic model as previously described, PAMERAH, simulating the glucoregulatory system of humans and rodents. GRI concepts are grouped into three mechanistic classes: 1) intrinsic GRIs, 2) glucose‐responsive particles, and 3) glucose‐responsive devices. Each class is analyzed for optimal designs that maintain glucose levels within the euglycemic range. These derived GRI parameter spaces are then compared between rodents and humans, providing the differences in clinical translation success for each candidate. This work demonstrates a computational framework to evaluate the potential clinical translatability of existing glucose‐responsive systems, providing a useful approach for future GRI development.
A Rapid Self‐Pumping Organohydrogel Dressing with Hydrophilic Fractal Microchannels to Promote Burn Wound Healing
Authors: Lan Jinze , Shi Lianxin , Xiao Wuyi , Zhang Xiaobin , Wang Shutao 
Published: June 2023

AbstractBurn wounds pose great challenges for conventional dressings because massive exudates oversecreted from swollen tissues and blisters seriously delay wound healing. Herein, a self‐pumping organohydrogel dressing with hydrophilic fractal microchannels is reported that can rapidly drain excessive exudates with ≈30 times enhancement in efficiency compared with the pure hydrogel, and effectively promote burn wound healing. A creaming‐assistant emulsion interfacial polymerization approach is proposed to create the hydrophilic fractal hydrogel microchannels in the self‐pumping organohydrogel through a dynamic floating‐colliding‐coalescing process of organogel precursor droplets. In a murine burn wound model, the rapid self‐pumping organohydrogel dressings can markedly reduce dermal cavity by ≈42.5%, accelerate blood vessel regeneration by ≈6.6 times, and hair follicle regeneration by ≈13.5 times, compared with the commercial dressing (Tegaderm). This study paves an avenue for designing high‐performance functional burn wound dressings.
Manipulation of Charge Dynamics for Efficient and Bright Blue Perovskite Light‐Emitting Diodes with Chiral Ligands
Authors: Zhang Lingjiao , Hu Sujuan , Guo Min , Ren Yunfei , Wei Linfeng , Li Wenxuan , Lin Faxu , Yang Zhiyong , Yang Zhenyu , Liu Chuan , Liu Baiquan 
Published: June 2023

AbstractPerovskite light‐emitting diodes (PeLEDs) emerge as a promising class of optoelectronic devices for next‐generation displays and lighting technology. However, the performance of blue PeLEDs lags far behind that of their green and red counterparts, including the unachieved trade‐off between high efficiency and high luminance, severe efficiency roll‐off, and unsatisfactory power efficiency. Here, a multi‐functional chiral ligand of L‐phenylalanine methyl ester hydrochloride is strategically introduced into quasi‐2D perovskites, which can effectively passivate defects, modulate the phase distribution, improve photoluminescence quantum yield, guarantee high‐quality film morphology, and enhance charge transport. Furthermore, ladder‐like hole transport layers are established, boosting charge injection and balance. The resultant sky‐blue PeLEDs (the photoluminescence peak is 493 nm and the electroluminescence peak is 497 nm) exhibit an external quantum efficiency of 12.43% at 1000 cd m−2 and a record power efficiency of 18.42 lm W−1, rendering that the performance is among the best blue PeLEDs.
Structural Color Mixing in Microcapsules through Exclusive Crystallization of Binary and Ternary Colloids
Authors: Yang Sehee , Kim Young Geon , Park Sanghyuk , Kim Shin‐Hyun 
Published: June 2023

AbstractColloidal crystals are designed as photonic microparticles for various applications. However, conventional microparticles generally have only one stopband from a single lattice constant, which restricts the range of colors and optical codes available. Here, photonic microcapsules are created that contain two or three distinct crystalline grains, resulting in dual or triple stopbands that offer a wider range of colors through structural color mixing. To produce distinct colloidal crystallites from binary or ternary colloidal mixtures, the interparticle interaction is manipulated using depletion forces in double‐emulsion droplets. Aqueous dispersions of binary or ternary colloidal mixtures in the innermost droplet are gently concentrated in the presence of a depletant and salt by imposing hypertonic conditions. Different‐sized particles crystallize into their own crystals rather than forming random glassy alloys to minimize free energy. The average size of the crystalline grains can be adjusted with osmotic pressure, and the relative ratio of distinct grains can be controlled with the mixing ratio of particles. The resulting microcapsules with small grains and high surface coverage are almost optically isotropic and exhibit highly‐saturated mixed structural colors and multiple reflectance peaks. The mixed color and reflectance spectrum are controllable with the selection of particle sizes and mixing ratios.
Nitrogen‐Doped Carbon Quantum Dots on Graphene for Field‐Effect Transistor Optoelectronic Memories
Authors: Chaudhary Mahima , Xin Chenghao , Hu Zhelu , Zhang Dongjiu , Radtke Guillaume , Xu Xiangzhen , Billot Laurent , Tripon‐Canseliet Charlotte , Chen Zhuoying 
Published: June 2023

AbstractThe development of field‐effect transistor‐based (FET‐based) non‐volatile optoelectronic memories is vital toward innovations necessary to improve computer systems. In this work, for the first time, the unique charge‐trapping and charge‐retention properties of solution‐processed colloidal nitrogen‐doped carbon quantum dots (CQDs) are harnessed to achieve functional optoelectronic memories programmable by UV illumination with a multilevel writing possibility. Of particular note, long‐lasting memory function can be achieved thanks to the vast charge trapping sites provided by the N‐doped CQDs and the resultant photo‐gating effect is exercised on the graphene FET. The achieved memory can be erased by a positive gate bias which provides sufficient carriers to remove trapped charges through recombination. This study highlights the possibility to engineer high‐performance all‐carbon non‐volatile FET‐based optoelectronic memories through manipulating and coupling the charge‐trapping properties of colloidal CQDs and graphene.
Dynamics of the Lithium Metal Electrodeposition: Effects of a Gas Bubble
Authors: Jin Shoutong , Zhou Linming , Wu Yongjun , Zhu Shang , Zhang Qilong , Yang Hui , Huang Yuhui , Hong Zijian 
Published: June 2023

AbstractUnderstanding the dynamics of lithium metal electrodeposition is crucial to designing safe and reliable lithium metal anodes. In this study, a grand potential‐based phase‐field model is developed to investigate the effect of a gas bubble (which forms due to the internal side reactions) on the dynamics of the dendrite growth during electrodeposition. It is observed that with the presence of a static gas bubble, the dendrite growth is largely accelerated, owing to the accumulation of lithium ions on the far side of the bubble away from the anode surface, which can serve as an ion “reservoir” for the dendrite growth, leading to the tilting of the lithium dendrites toward the bubble. The effects of the bubble size and distance to the anode are further studied, demonstrating that the larger the bubble size and the closer to the anode, the longer the lithium dendrites will grow. Notably, with a mobile bubble, the dendrite growth can be delayed due to the “stirring effect,” where the motion of the bubble can facilitate the ion migration. This effect is maximized when the bubble moving speed is close to the electrodeposition speed. It is hoped that this study can serve as an example to exploit the effect of extrinsic factors on the dendrite growth dynamics.
A qualitative exploration of patient perspectives on psychosocial burdens and positive factors in adults with osteogenesis imperfecta
Authors: Rork W. Conor , Hertz Alyssa G. , Wiese Andrew D. , Kostick Kristin M. , Nguyen Dianne , Schneider Sophie C. , Shepherd Whitney S. , Cho Hannah ,   Members of the BBDC, Murali Chaya N. , Lee Brendan , Sutton V. Reid , Storch Eric A. 
Published: June 2023

AbstractOsteogenesis imperfecta (OI) is a pleiotropic, heritable connective tissue disorder associated with a wide range of health implications, including frequent bone fracture. While progress has been made to understand the spectrum of these physical health implications, the impact of OI on psychosocial well‐being, as well as protective factors that buffer against adverse psychosocial outcomes, remain understudied. This present study relies on a qualitative approach to assess patient perspectives on both protective and adverse psychosocial factors specific to OI in 15 adults with varying disease status. Semi‐structured interviews were conducted, subsequently coded, and themes extracted. Themes concerning psychosocial burdens (i.e., negative affective and behavioral impacts of disease status) and protective factors were identified from cooperatively‐coded transcripts (two coders per transcript). Participants reported experiencing an increase in negative affect and disease‐related distress after fracturing a bone and during recovery. Fear and concern specific to the uncertainty of future bone fractures and negative self‐image was common. In contrast to these negative impacts, participants additionally described positive orientations toward their disease and attributed positive traits to their lived experience with a chronic disease. While limited due to small sample size and lack of ethno‐racial diversity, findings highlight a need for continued research on the relationship between OI disease status and psychosocial outcomes, as well as the development of psychological interventions designed for OI populations. Findings have relevant clinical applications for healthcare providers working with those diagnosed with OI.
Identification and molecular characterization of two recurrent missense mutations in the RS1 gene in two families with X‐linked retinoschisis from North India
Authors: Chatterjee Souradip , Gupta Shashank , Kirola Laxmi , Chandra Abhishek , Mukherjee Ashim , Mutsuddi Mousumi 
Published: June 2023

AbstractX‐linked retinoschisis (XLR) is a rare medical condition that involves in the splitting of neurosensory layers and the impairment of vision in the retina. In majority of the XLR cases, pathogenic variants in Retinoschisin 1 (RS1) gene have been implicated in males with an early age of onset during early childhood. In the present study, we have recruited two North Indian families having multiple affected male members, who were diagnosed with XLR. The entire protein‐coding region of RS1 was screened by PCR‐Sanger sequencing and two recurrent pathogenic variants (p.I81N and p.R102Q) were unraveled. The in vitro study of these variants demonstrated the aggregation of mutant RS1 within the endoplasmic reticulum. Furthermore, mutant forms of this protein showed significant intracellular retention, which was evident by the absence of retinoschisin protein fractions in the extracellular media. These inferences were also supported by extensive bioinformatics analysis of the mutants, which showed dramatic conformational changes in the local structure of retinoschisin. Thus, our study suggests that the identified pathogenic variants interfere with proper protein folding, leading to anomalous structural changes ultimately resulting in intracellular retention of retinoschisin within the retina.
Survivorship and the second epidemiological transition in industrial‐era London
Authors: Yaussy Samantha L. , DeWitte Sharon N. , Hughes‐Morey Gail 
Published: June 2023

AbstractObjectivesThe second epidemiological transition describes a shift in predominant causes of death from infectious to degenerative (non‐communicable) diseases associated with the demographic transition from high to low levels of mortality and fertility. In England, the epidemiological transition followed the Industrial Revolution, but there is little reliable historical data on cause of death beforehand. Because of the association between the demographic and epidemiological transitions, skeletal data can potentially be used to examine demographic trends as a proxy for the latter. This study uses skeletal data to examine differences in survivorship in London, England in the decades preceding and following initial industrialization and the second epidemiological transition.Materials and MethodsWe use data (from n = 924 adults) from London cemeteries (New Churchyard, New Bunhill Fields, St. Bride's Lower Churchyard, and St. Bride's Church Fleet Street) in use prior to and during industrialization (c. 1569–1853 CE). We assess associations between estimated adult age at death and time period (pre‐industrial vs. industrial) using Kaplan–Meier survival analysis.ResultsWe find evidence of significantly lower adult survivorship prior to industrialization (c. 1569–1669 and 1670–1739 CE) compared to the industrial period (c. 1740–1853 CE) (p < 0.001).DiscussionOur results are consistent with historical evidence that, in London, survivorship was improving in the later 18th century, prior to the recognized beginning of the second epidemiological transition. These findings support the use of skeletal demographic data to examine the context of the second epidemiological transition in past populations.
A Divergent Polyene Cyclization for the Total Synthesis of Greenwayodendrines, Greenwaylactams, Polysin and Polyveoline
Authors: Plangger Immanuel , Pinkert Tobias , Wurst Klaus , Magauer Thomas 
Published: June 2023

AbstractWe present a concise asymmetric total synthesis (5–8 steps) of nine sesquiterpenoid alkaloids featuring four different tetra‐/pentacyclic scaffolds. To this end, a novel, bioinspired indole N‐terminated cationic tricyclization has been developed, enabling the divergent synthesis of greenwayodendrines and polysin. Subtle variation of the C2‐substituted indole cyclization precursor allowed switching between indole N‐ and C‐termination. For the latter, a subsequent Witkop oxidation enabled conversion of the cyclopentene‐fused indole into the eight‐membered benzolactam to directly furnish the family of greenwaylactams. In addition, a diastereomeric C‐termination product has been elaborated to provide access to polyveoline.
Comparative study of the gular gland of three species of Molossidae bats (Mammalia: Chiroptera) from South America
Authors: Rodriguez Florencia Evelyn , Olea Gabriela Beatriz , Aguirre María Victoria , Argoitia María Antonella , Claver Juan , Lombardo Daniel Marcelo 
Published: June 2023

AbstractThe gular gland is a skin gland located in the suprasternal region of adult males of some bat families. Knowledge of the morphology and functional aspects of these gland types is often limited. This study aimed to describe the structure and composition of the gular glands of three molossid species (Eumops patagonicus, Molossus fluminensis and Molossus molossus) with respect to their reproductive activity and to define the mechanism involved in secretion release. Different histological, histochemical and immunohistochemical techniques were used to achieve these goals. The results revealed that the size and composition of this gland are variable and are mostly related to the lipid content during the reproductive season. The results also documented, for the first time, the occurrence of mechanoreceptors associated with the surface of the glandular duct by detecting an S100 protein, indicating that an external stimulus activates secretion. Previous studies on other species have classified the gland using obsolete criteria; hence, we adopted a new classification of adenomeres in this study. Moreover, we investigated the gland secretion mechanism previously proposed. This study defines the implications of this gland in the reproduction of this species. Our preliminary interpretation of the function of the gular gland is that it is a cutaneous exocrine gland activated by mechanoreceptors involved in the reproductive behaviour of the Molossidae family.
Skincare potential of a sustainable postbiotic extract produced through sugarcane straw fermentation by Saccharomyces cerevisiae
Authors: Duarte Marco , Carvalho Maria João , de Carvalho Nelson Mota , Azevedo‐Silva João , Mendes Adélia , Ribeiro Inês Pinto , Fernandes João Carlos , Oliveira Ana L. S. , Oliveira Carla , Pintado Manuela , Amaro Ana , Madureira Ana Raquel 
Published: June 2023

AbstractPostbiotics are defined as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” They can be produced by fermentation, using culture media with glucose (carbon source), and lactic acid bacteria of the genus Lactobacillus, and/or yeast, mainly Saccharomyces cerevisiae as fermentative microorganisms. Postbiotics comprise different metabolites, and have important biological properties (antioxidant, anti‐inflammatory, etc.), thus their cosmetic application should be considered. During this work, the postbiotics production was carried out by fermentation with sugarcane straw, as a source of carbon and phenolic compounds, and as a sustainable process to obtain bioactive extracts. For the production of postbiotics, a saccharification process was carried out with cellulase at 55°C for 24 h. Fermentation was performed sequentially after saccharification at 30°C, for 72 h, using S. cerevisiae. The cells‐free extract was characterized regarding its composition, antioxidant activity, and skincare potential. Its use was safe at concentrations below ~20 mg mL−1 (extract's dry weight in deionized water) for keratinocytes and ~ 7.5 mg mL−1 for fibroblasts. It showed antioxidant activity, with ABTS IC50 of 1.88 mg mL−1, and inhibited elastase and tyrosinase activities by 83.4% and 42.4%, respectively, at the maximum concentration tested (20 mg mL−1). In addition, it promoted the production of cytokeratin 14, and demonstrated anti‐inflammatory activity at a concentration of 10 mg mL−1. In the skin microbiota of human volunteers, the extract inhibited Cutibacterium acnes and the Malassezia genus. Shortly, postbiotics were successfully produced using sugarcane straw, and showed bioactive properties that potentiate their use in cosmetic/skincare products.
Alginate/chitosan hydrogels as perspective transport systems for cefotaxime
Authors: Shilova Svetlana V. , Mirgaleev Grigory M. , Romanova Ksenia A. , Galyametdinov Yury G. 
Published: June 2023

AbstractThis work reports synthesis of pH‐responsive alginate/chitosan hydrogel spheres with the average diameter of 2.0 ± 0.05 mm, which contain cefotaxime that is an antibiotic of the cefalosporine group. The spheres provided the cefotaxime encapsulation efficiency of 95 ± 1%. An in vitro release of cefotaxime from the spheres in the media that simulate human biological fluids in peroral delivery conditions was found to be a pH‐dependent process. The analysis of cefotaxime release kinetics by the Korsmeyer–Peppas model revealed a non‐Fickian mechanism of its diffusion, which may be related to intermolecular interactions occurring between the antibiotic and chitosan. Conductometry, UV spectroscopy, and IR spectroscopy were used to study complexation of chitosan with cefotaxime in aqueous media with varied pH, characterize the composition of the complexes, and calculate their stability constants. The composition of the cefotaxime–chitosan complexes was found to correspond to the 1.0:4.0 and 1.0:2.0 molar ratios of the components at pH 2.0 and 5.6, respectively. Quantum chemical modeling was used to evaluate energy characteristics of chitosan–cefotaxime complexation considering the influence of a solvent.