bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico Assessment of Dipeptidyl Peptidase 4 (DPP-4) Inhibiting Potential of a few Bioactive Compounds Present in Black Rice Bran for Effective Management of Postprandial Hyperglycemia
Authors: Bhuyan Pranjal , Ganguly Mausumi 
Published: January 2023

Abstract
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of prescription medicines that are used to control hyperglycemia in adults with type 2 diabetes. DPP-4 inhibitors lower blood sugar by helping the body increase the level of the hormone insulin after meals. In recent years many phenolic compounds, isolated from folk medicinal plants with anti- diabetic activity, are proved to show potent inhibitory effects against DPP- 4 enzyme. Black rice bran extract, which is rich in phenols, produces hyperglycemic effect on experimental animals. The present study was designed to evaluate molecular interactions existing between the major bioactive compounds present in black rice bran and DPP-4 enzyme. Molecular docking, binding energy calculation, evaluation of ADMET properties and Molecular Dynamics simulation for 50 nanoseconds were carried out to reveal the nature and stability of the enzyme-ligand complex formed due to such interactions. The results obtained indicate that out of the six bioactive compounds chosen, C3G (cyanidin 3-O-glucoside) and FLS (6´-O-feruloylsucrose) have the highest docking scores and they can produce stable complexes with DPP-4 which might lead to its inactivation. Therefore, it can be concluded that black rice bran extract may produce antidiabetic activity by inhibiting the DPP-4 enzyme. Moreover, the pharmacokinetic studies reveal that the compounds chosen are safe and produce no hepatotoxicity. This preliminary theoretical study can provide a strong base for further studies towards the development of lead molecules for new antidiabetic drugs with lower side effects.
An Artificial Neural Network Model for Short Term Traffic Flow Prediction in Two Lane Highway in Khulna Metropolitan City, Bangladesh
Authors: Shaik Md. Ebrahim , Islam Monirul , Kobir Md. Ripon , Furkan Kazi 
Published: January 2023

Abstract
Short Term traffic flow prediction is one of the most major topics of research in traffic engineering field. It's incredibly useful in the design of a more modern transport network that can manage traffic signals and reduce congestion. Short Term traffic flow is a challenge that a third-world country like Bangladesh is all too familiar with. Khulna Metropolitan City, like the other cities of Bangladesh, is gradually becoming more aware of this situation. The Khulna-Jashore National Highway (N-7), which runs through the city and provides it a linear shape, serves as the backbone of the Khulna Metropolitan City traffic flow. This study developed an Artificial Neural Network (ANN) model for the Short Term Traffic Flow Prediction in Two Lane Highway in Khulna Metropolitan City, Bangladesh. From March 1, 2021, through June 30, 2021, data was collected during 600–900 and 1200–1500 h. Extremely good quality electronic cameras were utilized to record the vehicles on the full designated length. In the regression graphs, the network outputs were displayed with targets for the training, validation, and test sets. The various speed level parameters for which the fit is reasonable for all data sets, with R values of 0.98426 in each case. The various traffic volume parameters for which the fit is reasonable for all data sets, with R values of 0.96758 in each case. The model's superiority is indicated by its low mean squared error values. This study provides an opportunity to provide a suitable alternative for Short Term traffic flow forecasting in Khulna Metropolitan City with traffic flow conditions for two-lane undivided highways.
Characterization of size segregated fungal bioaerosols in and around a Sugar Mill of Western Uttar Pradesh, India
Authors: Tyagi Swati , Srivast Arun 
Published: January 2023

Abstract
Suspended particles of biological origin that comprising of virus, animal debris, fungal spores known as bioaerosols have become a major concern in the past decades. The present study reports the concentration and size distribution of fungal bioaerosol in around a sugar mill situated in the Muzaffarnagar region of Uttar Pradesh, India. The sampling was performed in the winter months when the mill used to be operational mode. The highest mean fungal concentration was observed at the cutter site (4022 ± 321 cfu/m3) and lowest at storage site (832 ± 85 cfu/m3). The maximum and minimum concentration of fungal bioaerosol was observed during January (3090 ± 174 cfu/m3) and March (629 ± 69 cfu/m3) respectively. During the entire sampling period the fine fraction of fungal bioaerosol was observed to be significantly high at all the sites, whereas coarse fraction was lower. The association between fine and coarse fractions of bioaerosols showed a very strong positive relationship. The levels of fungal bioaerosol and their association with the meteorological parameters in sugar mill were also conducted. A positive association with the relative humidity and wind speed were observed at significant level p<0.05 whereas a negative relation was observed with temperature at p < 0.05. The lifetime average daily dose was calculated for both inhalation and dermal, among them LADDinhalation is ~5 times over LADDdermal. The health risk index was observed as <1 for both inhalation and dermal route whereas HIinhalation value was 105 times higher than the HIdermal value. The dominant fungus found in the air of examined dwellings was Penicillium spp., Aspergillus spp., Cladosporium spp., and Alternaria spp., which occurred predominantly at all the sites during the months of the sampling period.
Quality of life and its associated factors among women diagnosed with pelvic organ prolapse in Gynecology outpatient department Southern Nations, Nationalities, and Peoples region public referral hospitals, Ethiopia 2022
Authors: Tefera Zewdu 
Published: January 2023

AbstractBackground Pelvic organ prolapse is an important public health issue influences millions of adult women’s lives; through limitations on physical, social, and sexual activities as well as psychological distress. However, there were no reports on the quality of life for women with pelvic organ prolapse in Ethiopia. Therefore this study amid to assess the magnitude of quality of life and its associated factors among women diagnosed with pelvic organ prolapse in Gynecology outpatient department Southern Nations, Nationalities, and Peoples region public referral hospitals; Ethiopia. Method An institutional-based cross-sectional study was conducted in Southern Nations, Nationalities, and Peoples region of public referral hospitals from May1-July 4, 2022 among 419 diagnosed women with pelvic organ prolapse. A validated tool was used to collect the data. The collected data were entered into EPI data version 3.1 and analyzed using the Statistical Package for Social Sciences. Bivariable and multivariable logistic regression was computed. The p-value of < 0.05 was used to declare the final statistical significance. Result A total of 409 women with pelvic organ prolapse were included in the study, giving a response rate of 97.6%. The overall poor quality of life was 57.5%. Regarding the quality of life domains; personal relationships (73.6%), were highly affected, and sleep/energy (24.2%) was the least affected domain. Stage III/IV prolapse (AOR = 4.61, 95% CI: 2.51, 8.48), menopause (AOR = 3.59, 95% CI: 1.85, 6.97), unmarried women(widowed, divorced) (AOR = 3.81, 95% CI: 2.02, 7.19), low-income level (AOR = 7.48, 95% CI: 3.67, 15.24), and longer duration of prolapse (AOR = 8.8, 95% CI: 4.81, 16.11), were significantly associated with poor quality of life. Conclusion More than half of women with pelvic organ prolapse had a poor quality of life. Stage III/IV prolapse, longer duration of prolapse, low-income level, menopause women, and unmarried women are statistically significant factors for the quality of life of women with POP. Therefore, Ethiopian Ministry of health with their stakeholders should develop an early detection and treatment strategy, and financial support for women with pelvic organ prolapse.
Evaluation of the Reasons for Health and Safety Risks in Agriculture by Integration of ANP and PROMETHEE Methods
Authors: AKSÜT Güler , Eren Tamer 
Published: January 2023

Abstract
Background: Agriculture serves humanity as one of the most important professions. In Turkish agriculture, a structure in which small family businesses are more concentrated in agricultural production in rural areas is dominant. Health and safety is the most critical concern as those working in the sector often perform their activities in a dangerous, stressful and disturbing environment. All employees have the indisputable right to return to their families safely. For this employee's right, safety and health measures should be taken in the work areas. For this reason, this study it is aimed to list the factors that cause exposure to risks in the sector.
Methods: Multi-Criteria Decision Making Methods were used in the study. The weights of the criteria were calculated by the ANP method. The ranking of the alternatives was carried out with the PROMETHEE method.
Results: Alternatives that cause exposure to risks in the agricultural sector are lack of awareness and knowledge, insufficient professional information, education/literacy level; age, gender, and child employee; inadequacy of appropriate personal protective equipment, transportation, accommodation, and working conditions.
Conclusions: Occupational health and safety experts, ergonomists, doctors, engineers, manufacturers, IoT developers, and international organizations should cooperate to prevent employee health and safety risks.
Demographic examination of Brown hare (Lepus europaeus) stocks with special reference during birth and survival in Eastern Hungary
Authors: Majzinger István , Farkas Péter , Kusza Szilvia 
Published: January 2023

Abstract
The aim of the research was to demographically examine a brown hare population, in particular to analyze the age structure, the time of birth and the survival pattern by hunting bag. The data collection was carried out between 2014-2016 in Eastern Hungary. A total of 169 organ samples were examined. In the studied area, the majority of the samples were under 1 year old and 1-2 year olds. The older age group occured 4.1-18.6% in the hunting bag. Nearly half of the hares under one year of age were individuals 4 to 7 months of age at the time of the hunts, which coincided with the time of dispersion of the individuals. Survival rates of hares under one year of age were found to be lower than those of older individuals in all cases. Overall, the age-specific survival probability of males is considered to be more balanced than that of females between years. Studies have shown that the age composition and survival patterns of stocks vary from year to year.
Comparison of the performance of SARS-CoV-2 RNA qRT-PCR testing based on expectorated and drooled saliva samples
Authors: Kay Olivia , Futschik Matthias Erwin , Turek Elena , Chapman David , Carr Simon , Sudhanva Malur , Klapper Paul , Cox Tony , Hill Michael , Cole-Hamilton Joanna , Marks Peter , Tunkel Sarah , Peto Tim , Davies Lindsey , Fowler Tom 
Published: January 2023

Abstract
Purpose
Saliva has been considered a suitable sample material for SARS-CoV-2 testing but uncertainty remained regarding the sensitivity and reliability of different saliva collection methods for community mass testing. This study aimed to investigate the potential utility of expectorated saliva (ES) and drooled saliva (DS) through a large cohort study.
Methods
ES and DS samples were collected in a two-stage non-randomized prospective cohort study. Their utility for SARS-CoV-2 RNA qRT-PCR testing was assessed by comparison with results for combined throat and nose (CTN) swabs. A total of 2,878 subjects were recruited, from which 2,747 were evaluable for statistical analyses.
Results
Using CTN swab-based results as reference,DS- and ES-based tests showed the same high level of concordance (98% vs 98%) or specificity (99% vs 99%). Sensitivity seemed to be higher for DS than for ES (93% vs 80%) but not significantly once viral concentration was taken into account. Multivariable analysis indicated however an inferior sensitivity of saliva-based testing for female compared to male subjects with low viral burden. Assuming no false positive qRT-PCR results, an unbiased comparison showed no significant difference in sensitivity between saliva- and swab-based testing.
Conclusion
SARS-CoV-2 RNA testing based on saliva showed high diagnostic accuracy and can be considered an alternative where swabbing may not be tolerated or operationally feasible. Drooled saliva yielded the same diagnostic performance compared to expectorated saliva and may present a preferred option with reduced aerosol risk and increased compliance. Observed sex-specific difference in detection performance however warrant further investigations.
Biomedical Text Readability and Cognitive Burden after Hypernym Substitution with Fine-Tuned Large Language Models
Authors: Swanson Karl , He Shuhan , Calvano Josh , Chen David , Telvizian Talar , Schwell Jacob , Jiang Lawrence , Chong Paul 
Published: January 2023

Abstract
We aimed to study the simplification of biomedical text via large language models (LLMs). Specifically, we finetuned three language models to perform substitutions of complex words and word phrases for their respective hypernym in biomedical definitions. This process was then evaluated by readability metrics, and two measures of sentence complexity: the measure of lexical diversity (MLTD), and mean dependency distance (MDD) scoring. A sample of 1,000 biomedical definitions in the National Library of Medicine’s Unified Medical Language System (UMLS) was processed with three approaches, each with a different language models and analysis revealed an increase in FK score and a reduction in reading grade level across all metrics. Reading scores improved from a pre-processed collegiate reading level to a post-processed US high-school level. An inter-approach comparison showed that our GPT-J-6b approach had the best improvement in MLTD and MDD. This study demonstrates the merit of hypernym substitution in improving the readability and improving measures cognitive burden of biomedical content for the general public.
Feasibility and Tolerability of Surface Guided Radiotherapy in Breath-Hold Liver Stereotactic Body Radiotherapy
Authors: Turna Menekşe , Küçükmorkoç Esra , Rzazade Rashad , Canoğlu Mehmet Doğu , Küçük Nadir , Çağlar Hale Başak 
Published: January 2023

Abstract
Background: Intra-fractional motion is one of the main challenges in SBRT. Breath-hold (BH) technique minimizes the tumor motion. However, reproducibility and consistency are critically important. Surface tracking systems integrated into treatment enable motion tracking with three-dimensional camera technology. Surface guidance was integrated with Varian EDGE and used at multiple treatment sites since 2018 in our department. After four years of experience, in this study, we aim to publish patient-reported outcomes (PROMs), feasibility, and tolerability of surface guidance (SGRT) with breath-hold SBRT in a specific subgroup: liver metastases.
Methods: Patients with liver metastasis treated with breath-hold and SGRT were evaluated prospectively. Two-step, seven-question surveys were applied after CT simulation and treatment. Treatment duration and BH number were recorded. In addition, factors that can affect the SGRT and treatment time were evaluated.
Results: Between April 2021- May 2022, 41 patients were treated in 171 fractions. According to the PROMs, previous training was beneficial, and holding breath is tolerable. Patients have a little stress about taking an active role in the treatment. Karnosky performance status (KPS), age, lung volume, or any condition affecting lung capacity, previous BH history, and being a native speaker are not correlated with treatment time and BH with SGRT tolerability. Only female patients have better BH performance with SGRT treatments than male patients (p: 0,02).
Conclusion: SGRT applications in BH are tolerable and feasible in liver SBRT treatments. There is no specific subgroup that cannot be tolerated with this method.
Groundwater Potential Modelling and Aquifer Zonation of a Typical Basement Complex Terrain: A Case Study
Authors: Ogundana Ayodeji K , Falae Philips Omowumi 
Published: January 2023

Abstract

Geophysical exploration using Vertical Electrical Resistivity (VES) techniques has been employed to study the groundwater potential and vulnerability of selected locations. The objective is to investigate nature and groundwater yielding potential of the area under investigation and to understand roles of various geophysical parameters in groundwater potential of the area and their effective characterisation of hydrogeological units. The juxtaposition of contour maps which show variations in hydrogeological parameters in a continuum manner is worthwhile. The results have really shown that the general trend of groundwater potential within the study area is low as indicated from the hydraulic conductivity, transmissivity and porosity. The generated groundwater potential map of the area can be used in designing appropriate groundwater exploration and management within the area and can serve as a roadmap for further expansion of the research work.
The mechanism of IL-1β-mediated Piezo1 regulating chondrocyte autophagy and apoptosis through PI3K/AKT/mTOR signaling pathway
Authors: Chen Wanzhuo , Lu Xinzhe , Wang Wenzhe , Zhang Haining 
Published: January 2023

Abstract
For the pathogenesis of osteoarthritis (OA), the classical view is that chondrocyte apoptosis is associated with and may cause age-related joint degeneration. Recent observations indicate that Piezo1, a mechanical stress channel expressed in articular cartilage, plays a key role in this process. We wanted to investigate whether other conditions activate the expression of Piezo1 in chondrocytes. Therefore, we simulated OA to investigate whether Piezo1 gene expression and channel function were affected by the inflammatory factor, interleukin-1β, and the role of Piezo1 in the regulation of autophagy and apoptosis of chondrocytes. After primary culture of human chondrocytes, the primary chondrocytes were treated with different concentrations of IL-1β. It was found that IL-1β up-regulated the expression of Piezo1 in human chondrocytes. After Piezo1 activation, we analyzed the expression of autophagy and apoptosis of chondrocytes, and investigated whether the downstream PI3K/AKT/mTOR pathway mediated the autophagy and apoptosis of chondrocytes. IL-1β activates Piezo1 to inhibit chondrocyte autophagy and promote chondrocyte apoptosis, represented by up-regulation of related proteins c-caspase 3, Bax expression and down-regulation of Bcl2, LC3, p62 expression. Piezo1-siRNA inverted this step. Inhibition of PI3K/AKT/mTOR pathway reduces Piezo1 inhibition of chondrocyte autophagy and activation of chondrocyte apoptosis. Therefore, IL-1β-mediated Piezo1 inhibition of chondrocyte autophagy and promotion of chondrocyte apoptosis through the PI3K/AKT/mTOR pathway is considered a novel pathogenesis of osteoarthritis.
Research on Network Security Situation Awareness based on Netlogo
Authors: Zhou Yanling , Cao Jing , Zhang Yunxiang 
Published: January 2023

Abstract
Data security has become an increasingly important issue for Internet users due to recent data security incidents. Network threat characteristics are the most important factors in network security situation awareness. With the characteristic data of network threats, network managers can analyze, predict, and prevent network threat events. Honeypot is a kind of active defense technology against security threats. It is a decoy system which attracts attackers and has loopholes. It observes the security situation of the whole network through the perception system, and makes judgment, analysis and rescue of network security events in time according to the observed data. It can predict possible future network security events, so as to make timely plans. Because, honeypot is an active network security tool, the network attack data collected by honeypot has high research and utilization value. This paper mainly carries on the detailed research from three aspects, namely the honeypot research, the network security situation assessment and the network security situation prediction. And a network security situation assessment model based on honeypot technology is proposed. In this model, the PSO algorithm is optimized by optimizing the inertia weight, limiting the maximum particle velocity and increasing the interparticle force. The honeypot system proposed in this paper is a network security awareness system integrating probe, honeypot and management terminal. It studies the network security situation awareness problem based on the honeypot system. At the same time, in the aspect of network security situation assessment, the risk value of network attack situation is constructed according to the type and danger degree of honeypot attack. Combined with the improved PSO algorithm, the highest risk data in the historical attack data and the corresponding time are obtained. In the aspect of network security situation prediction, artificial neural network is used to predict the risk value of network attack situation in the next time period. The experimental results show that the improved PSO algorithm has fast convergence speed and can output the highest risk value faster; the predicted value of artificial neural network is close to the true value, which can realize the prediction of risk value well.
Effect of forest species on soil nutrient stocks in derived savannah ecosystem, in Abeokuta, southwest Nigeria
Authors: Azeez J. O. , Onasanya O. O. , Bankole G. O. , Salaudeen G. T. 
Published: January 2023

Abstract
The study aims to determine the impact of forest tree species of on some soil properties and soil nutrient stocks. Triplicate soil samples were collected from mono species tree clusters consisted of Gmelina arborea, Bambusa vulgaris, Treculia africana, were selected with arable crop farm, fadama and organic farm and analyzed for some soil chemical properties and nutrient stocks at 0–20 cm, 20–40 cm, 40–60 cm and 60-80cm using standard procedures. Results indicated that soil organic matter under the different tree types are concentrated between 0–20 cm and 20–40 cm. There was increase in soil pH, electrical conductivity, organic matter, hydraulic conductivity and bulk density at 20–40 and 40–60 cm depths. Soil nutrient stocks (sulphate, phosphate and nitrates) are concentrated at depths 20–40 cm and 40–60 cm. On the average soils accumulated 75.57 Mg PO43− ha− 1, 56.19 Mg SO42− ha− 1 and 37.57 Mg NO3− ha− 1. Soils under tree plantations had higher nutrient stocks compared with the non-tree landuse, with Bambusa vulgaris having the highest accumulation of nutrients. Tree species improved soil properties and nutrient stocks than the non-tree land use. Treculia africana and Bambusa vulgaris had higher soil nutrient stocks than other landuse.