bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Transcatheter Mitral Valve Repair in Patients With Rheumatoid Arthritis – A Retrospective Study from the National Inpatient Sample Database
Authors: Abdelradi Amr , Pai Rima , Feher Cynthia , Sostin Oleg 
Published: May 2023

Abstract

Introduction: Transcatheter mitral valve repair (TMVR) with the MitraClip device is a widely performed procedure for both primary and secondary mitral regurgitation. Several studies have assessed outcomes of TMVR in subpopulations with different comorbidities. However, there is no data on the safety and outcomes of TMVR in patients with rheumatoid arthritis (RA), which is a known independent risk factor for cardiovascular disease.
Methods: We performed a retrospective analysis using data from the Nationwide Inpatient Sample (NIS) database from 2016-2019 to assess the outcomes of TMVR in patients with RA vs. without RA. Our primary outcome was in-hospital mortality following TMVR. Our secondary outcomes included the association of pre-specified comorbidities with in-hospital mortality and rates of post-procedural complications between RA vs. without RA groups.
Results: A total of 4,176 patients were included in analysis (85 with RA, 4091 without RA). Our results showed no significant difference in mortality between patients with versus without RA (OR 0.798, p = 0.825). Patients with underlying diabetes had significantly increased mortality following TMVR (OR 1.843, p = 0.027). Patients with underlying CABG had significantly lower mortality following TMVR (OR 0.439, p = 0.047). Multivariate regression analysis of in-hospital complications showed no significant difference in complications between the RA vs. without RA groups.
Conclusion: Our data shows no increased risk of in-hospital mortality or complications in patients with RA following TMVR.
In silico Analysis and Molecular Dynamic Modeling of Three-dimensional Structure of Glutelin type-B 5-like Proteins from Proso Millet: Effects of Temperature and Electric Field
Authors: Akharume Felix , Singh Ashutosh , Korotkov Konstantin , Adedeji Akinbode 
Published: May 2023

AbstractThis study determined the 3D structure of glutelin type-B 5-like (GTB) protein from proso millet using homology modeling and investigated the effects of simulated temperature and static electric field on its secondary structures, solvent accessibility surface area (SASA), the radius of gyration (Rg), root mean square deviation (RMSD), and total dipole moment. The result showed that the structure of GTB is majorly a protomer that comprises three monomers with one jelly-like β-barrel and two extended helix domains, and the remaining 35% as coils. Based on the molecular dynamic simulation, the secondary structure of the protein was not disrupted at temperatures between 300–400 K and static electric fields of between 0.1-3 V/nm, albeit the loss of a few amino acid residues. The RMSD increased significantly with an increase in temperature, static electric field, and simulation time. But the Rg and SASA decreased for the same conditions, suggesting that, the protein structure is compacting during thermal and electrical treatment.
Rep-Tracker: a lightweight tiny ball tracking method using structure re-parameterization
Authors: Wu Wenjia , Ren Lingfei , Yang Wenyuan 
Published: May 2023

Abstract
Vision-based object tracking techniques are used to analyze sport competition videos. The latest tennis tracking models achieve very high accuracy. However, high precision networks often imply higher computational complexity, which in turn brings higher hardware requirements. Also, part of the networks suffer from the problem of different degrees of adaptation to different courses. In this paper, a lightweight tiny ball tracking method is developed based on deep learning call Rep-Tracker, which incorporates the structure re-parameterization strategy on the basis of the pruned VGG-style model to construct a tennis tracking network. Firstly, the video frames will be sent into a pruned VGG-16 encoder follow by a decoder composed of deconvolution, and heatmap will be output after a softmax layer. Based on the encoder-decoder structure , pruning methods are used to reduce the number of non-essential convolutional layers and channels in the network. Secondly, residual connections are added at each layers to form a multi-branch block at training time. By using a structural re-parameterization strategy, each branch in a multi-branch block will be equivalently transformed into a shape consistent convolution. The trained blocks are convert into a single convolution layer for inference. Finally, based on the heatmap, the position of the target object is obtained by Gaussian distribution function 1 Springer Nature 2021 L A T E X template Article Title and Hough gradient function. In the tennis tracking task our method achieves a high accuracy with GFLOPs only 1.29 on RTX 3080 GPU.
A risk model based on the tumor infiltrating CD8+T cells correlated with the prognosis and therapy in bladder urothelial carcinoma
Authors: Xin Shiyong , Li Ruixin , Su Junjie , Cao Qiong , Wang Haojie , Wei Zhihao , Wang Chengliang , Zhang Chengdong , Zhang Jianguo 
Published: May 2023

Abstract
Background: With growing evidence that immune cells contribute greatly in tumor progression, identifying their role in tumor prognosis and therapy is crucial. Our aim is to comprehensively characterize tumor infiltration immune cells in BLCA and identify valuable immune cells and gene model related to prognosis and therapy in BLCA.
Methods: Firstly, after comparing the relationship between the abundance of infiltrating immune cells and prognosis, CD8+T cell was selected to establish the risk model, which was constructed based on five key genes(GNLY, LHFPL6, APOL6, LRP1, and UBA7). Then ROC curve was drawn to demonstrate the risk model own high prognosis predictive value in BLCA.
Results: Our results of correlation analysis showed that riskscore were negatively correlated with several steps of the tumor immune cycle, such as infiltration of tumor tissue T cells, and positively correlated with the fourth step of the cancer immune cycle. Furthermore, riskscore was negatively correlated with the expression of CD8,CD274,IFNG, Merck18, and several common immune checkpoint (TIGIT, CTLA4, HAVCR2 LAG3, PDCD). Moreover, tumor exclusion score and Tumor Immune Dysfunction and Exclusion (TIDE) score were higher in high-score group than that in low-score group. Importantly, riskscore was negatively correlated with the enrichment score of immunotherapy-related pathways, and the therapeutic benefit of low-score group was greater than that in high-score group. A total of 171 chemotherapy and targeted drugs were identified, of which the high-score group were more sensitive to 82 drugs and the low-score group were more sensitive to the other 89 drugs. Among the commonly used chemotherapy drugs for BLCA, such as cisplatin and doxorubicin, the IC50 in low-score group was smaller and more sensitive. Subsequently, immunohistochemistry was used to make a verification on the risk model. Finally, we explored the relationship between APOL6 expression and clinicopathological characteristics and found that the expression of APOL6 was positively correlated with tumor grade.
Conclusions: Our results confirmed that the tumor infiltration CD8+T cells played a crucial role in the prognosis and therapy of BLCA,which may provide us a new inspiration and direction in prognosic prediction and therapy of bladder cancer in future.
Anti-Ro52 antibody is a risk factor for depression and anxiety in patients with connective tissue diseases
Authors: Yang Leilei , Wang Xiaoqin , Kang Haiyan , Gu Bingjie , Ren Qijie , Su Dinglei , Shen Minning 
Published: May 2023

Abstract
The risk of mental disorders such as depression and anxiety is increased in connective tissue diseases (CTDs). However, little is known about whether this risk is related to autoantibodies. We conducted an observational, single-center, cross-sectional study to investigate the correlation of depression and anxiety with the presence of autoantibodies in patients with CTDs. Three hundred and fifty-two inpatients with CTDs were recruited and their demographic, serological and imaging data were collected through the medical record system. Depression and anxiety were assessed by the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 Scale (GAD-7) respectively. Analysis of variance (ANOVA), rank sum test, chi-square test and logistic regression were performed to investigate risk factors for depression and anxiety. The prevalence of depression (PHQ-9 ≥ 5) and anxiety (GAD-7 ≥ 5) in CTD patients was significantly higher than that in the Chinese general population (depression: 44.3% vs 32.2%, anxiety: 39.5% vs 22.2%). Sleep time was a protective factor for both depression and anxiety (OR = 0.719, 95% CI: 0.605 ~ 0.856, P = 0.0002 and OR = 0.639, 95% CI: 0.528 ~ 0.773, P < 0.0001, respectively) while anti-Ro52 antibody was a risk factor for them (OR = 5.545, 95% CI: 3.053 ~ 10.074, P < 0.001 and OR = 5.642, 95% CI: 3.071 ~ 10.363, P < 0.0001, respectively). Further analysis showed that anti-Ro52 antibody was a risk factor for depression and anxiety in all four subgroups, namely SLE, SS, RA, and other CTDs. CTD patients with the presence of anti-Ro52 antibody are more prone to depression and anxiety than those without it.
NFFNet : An Encoder-Decoder Net for Crack Detection based on Noise Filtering Fusion
Authors: Xie Yonghua , Zhuo Annan , Chen Ya , Bai Yong 
Published: May 2023

Abstract

Crack detection is a challenging and critical task for building collapse prevention. Cracks show weakcharacteristic and is easily interfered by noises such as spalling defects and grinding defects. Many seg-mentation methods improve the detection accuracy through fusing the encoder and decoder features.However, the encoder features contain spatial noises in low-level convolution layers and channel noisesin high-level convolution layers. Fusing these noisy encoder features and decoder features directly hasadverse impact on detection. To solve this problem, we design a noise filtering fusion module whichfilters the noises in encoder features and fuses the optimized encoder features with decoder features.The noise filtering fusion module consists of the channel and spatial noise filtering fusion module. Thenoise filtering fusion module is embedded in the improved encoder-decoder structure to constitute anend-to-end convolutional neural network, NFFNet. Experimental results on three crack datasets showthat the proposed method can effectively reduce the impact of the image noises, and the detectionperformance is superior to the othe
Early-onset familial essential tremor is associated with nucleotide expansions of spinocerebellar ataxia in China
Authors: Zheng Zhilin , Zhu Zeyu , Pu Jiali , Zhou Chen , Cao Lanxiao , Lv Dayao , Lu Jinyu , Zhao Gaohua , Chen Yanxing , Tian Jun , Yin Xinzhen , Zhang Baorong , Yan Yaping , Zhao Guohua 
Published: May 2023

AbstractBackgroundEssential tremor (ET) is a neurological disease characterized by action tremor in upper arms. Although its high heritability and prevalence worldwide, its etiology and association with other diseases are still unknown.MethodWe investigated 10 common spinocerebellar ataxias (SCAs), including SCA1, SCA2, SCA3, SCA6, SCA7, SCA8, SCA12, SCA17, SCA36, dentatorubral-pallidoluysian atrophy (DRPLA) in 92 early-onset familial ET pedigrees in China collected from 2016 to 2022.ResultWe found one SCA12 proband carried 51 CAG repeats withinPPP2R2Bgene and one SCA3 proband with intermediate CAG repeats (55) withATXN3gene. The other 90 ET probands all had normal repeat expansions.ConclusionTremor can be the initial phenotype of certain SCA and it is necessary to screen SCAs in ET patients, especially in early-onset and familial patients.
Protective effect of phage pSal-4 on chicken intestinal epithelial cells injured by Salmonella Enteritidis
Authors: Xie Ziqiang , Lv Xingbang , Zhong Cuihong , Wang Fangfang , Zhang Yongying , Li Yue , Huang Yangling , Liu Guanhui , Shi Yuxiang 
Published: May 2023

Abstract

Salmonella Enteritidis (SE) is one of the most important pathogens posing a huge threat to the poultry industry, bacteriophages are used as an alternative antibiotic product for the treatment of SE due to their specific bactericidal effect and safety. This study aimd to investigate the protective effect of bacteriophage against SE infection of chicken intestinal epithelial cells. Chicken intestinal epithelial cells were treated with different concentrations of bacterial suspension, and cell damage was assessed by measuring the changes of cell viability and observation by transmission electron microscopy. In the phage protection experiment, the phages were co-incubated with SE for 2, 4, and 6 h, the adhesion rate and invasion rate of bacteria and gene transcription levels of Occludin, Claudin-1, ZO-1, NF-κB p65, TNF-α and IL-6 in cells were determined. The results showed that the transcription level of immune factor gene in chicken small intestinal epithelial cells was significantly decreased, and the transcription level of tight junction protein gene was significantly increased. Phages could decrease the infection of bacteria to chicken intestinal epithelial cells. Furthermore, phages were able to alleviate inflammation and barrier integrity disruption inflicted by bacteria in the co-culture. Based on these observations, phages seemed to be promising candidates for the prevention and treatment of gastrointestinal bacterial infections.
GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease
Authors: Sachs Stephan , Götz Anna , Finan Brian , Feuchtinger Annette , DiMarchi Richard D. , Döring Yvonne , Weber Christian , Tschöp Matthias H. , Müller Timo D. , Hofmann Susanna M. 
Published: May 2023

Abstract
Background Agonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular GIPR:GLP-1R co-agonists, which are among the most promising drugs in clinical development for the treatment of obesity and type 2 diabetes. The therapeutic effect of chronic GIPR agonism to treat dyslipidemia and thus to reduce the cardiovascular disease risk independently of body weight loss has not been explored yet.Methods After 8 weeks on western diet, LDL receptor knockout (LDLR-/-) male mice were treated with daily subcutaneous injections of long-acting acylated GIP analog (acyl-GIP; 10nmol/kg body weight) for 28 days. Body weight, food intake, whole-body composition were monitored throughout the study. Fasting blood glucose and intraperitoneal glucose tolerance test (ipGTT) were determined on day 21 of the study. Circulating lipid levels, lipoprotein profiles and atherosclerotic lesion size was assessed at the end of the study. Acyl-GIP effects on fat depots were determined by histology and transcriptomics.Results Herein we found that treatment with acyl-GIP reduced dyslipidemia and atherogenesis in male LDLR-/- mice. Acyl-GIP administration resulted in smaller adipocytes within the inguinal fat depot and RNAseq analysis of the latter revealed that acyl-GIP may improve dyslipidemia by directly modulating lipid metabolism in this fat depot.Conclusions This study identified an unanticipated efficacy of chronic GIPR agonism to improve dyslipidemia and cardiovascular disease independently of body weight loss, indicating that treatment with acyl-GIP may be a novel approach to alleviate cardiometabolic disease.
Long-term effects of a 1940s nitrogen and phosphorus fertilization experiment on diatoms from Cache Lake (Algonquin Provincial Park, Ontario, Canada)
Authors: Christopher A.T. Wilkins , Kathleen M. Ruhland , Andrew M. Paterson , John P. Smol 
Published: May 2023

Abstract
Cache Lake, an ultra-oligotrophic Precambrian Shield lake located in Algonquin Provincial Park (Ontario, Canada), was manipulated in the summers of 1946 and 1947 when approximately 9.4 tons (cumulatively) of 12-24-12 (nitrogen-phosphorus-potassium) fertilizer was added to promote plankton growth and the possible enhancement of fish populations. Little is known about the long-term impacts of this lake manipulation, nor the effects of previous disturbances such as logging in the late-1800s, increased tourism following the extension of the Grand Trunk Railway to Cache Lake in 1896, limited cottage development starting ca. 1905, and subsequent construction of Highway 60 in the 1930s. We used a diatom-based paleolimnological approach to track limnological changes during the past ~ 200 years. Prior to the 1940s, assemblage changes were minimal, although small increases in, for example, Aulacoseira ambigua, likely tracked modest nutrient inputs from historical watershed disturbances. The most striking change was an increase in planktonic Fragilaria tenera in tandem with the near extirpation of the previously abundant Discostella stelligera from the sediment record that was concurrent with the 1946–1947 lake fertilization experiment. Although other lake sediment archives in the region record increases in D. stelligera with limnological changes linked to recent climate warming, this taxon never recovered to pre-disturbance abundances in Cache Lake following nutrient enrichment, but continued to be replaced by other planktonic taxa, also linked to recent warming (e.g. F. tenera, Asterionella formosa). The 1940s experimental fertilization has left a long-term legacy on Cache Lake diatoms, despite its return to ultra-oligotrophic conditions.
Transformation of a Vortex Cosine-hyperbolic-Gaussian Beam by an Airy Transform Optical System
Authors: Yaalou M. , Hricha Z. , Belafhal A. 
Published: May 2023

Abstract
The present paper investigates the Airy transformation of a vortex cosine-hyperbolic-Gaussian beam (vChGB). The analytical expression for this beam passing through an Airy Transform Optical System is derived in detail based on the Huygens-Fresnel integral. It is demonstrated that the Airy transform vChGB is a superposition of Airy and Airy prime modes. Numerical results show that the output beam is Airy-like with a central vortex, and its intensity distribution can be controlled by adjusting the initial vChGB parameters and control factors of the Airy Transform. The obtained results could be beneficial for the applications of Airy-related beams.
METHOD OF ASSESSMENT BY INTEGRITY AND SAFETY – MAIS METHOD A Comprehensive Approach to Evaluating the Integrity and Safety of Reinforced Concrete Structures
Authors: OLIVEIRA Ana Luiza , PANTOJA João , VARUM Humberto , PRADO Sara , MORAIS Rafael 
Published: May 2023

Abstract
The assessment of an existing structure is a complex activity that requires a realistic overview of the materials involved, the acting loads, environmental aggressiveness, and other factors in order to describe the correct functioning and adequately predict the level of structural safety. This paper proposes a probabilistic methodology that couples reliability analysis to a structural inspection and evaluation process: the Method of Assessment by Integrity and Safety - MAIS Method. The MAIS Method is an innovative approach used to quantify the integrity of existing buildings in reinforced concrete by identifying pathologies that may compromise their structural safety. This method is distinguished by its ease of applicability, which considers uncertainties in the data and, with parameterized inputs, facilitates the collection of variables required for the analysis. The approach streamlines the assessment process, integrating the two fundamental aspects of evaluating a structure: the identification of degradation phenomena and the assessment of the structure's resistance. The method employs probability theory to offer more accurate results, making it more reliable. The MAIS Method was applied to a building in the Asa Sul neighborhood of Brasilia, and with the aid of a risk matrix, was modeled to visualize the reliability of each element of the building. As a result, the structure presented a "medium-high" risk. Therefore, the MAIS Method presented a very satisfactory and consistent result with reality, assertive, being the kick-start of what can be a great contribution to the structural evaluation of assets and properties and it has enormous potential for application and collaboration in the field of structural assessment.
The mental health of younger adults after relief of the zero-COVID prevention policy in China: a cross-sectional study
Authors: Zhang Haihong , Xiong Min , Xie Nan , Zou Liqun 
Published: May 2023

Abstract
Background With the relief of the zero-COVID prevention policy in China, great changes in the COVID-19 pandemic took place. Against this backdrop, we aimed to investigate the impact of this policy shift on the mental health of younger adults in China.Methods A cross-sectional study was conducted using an online questionnaire survey between January 1st and February 28th, 2023. The survey aimed to estimate the prevalence of sleep quality, anxiety, and depression among participants aged 18-45years old. Pearson's correlation analysis was used to explore the relationships between these variables. Logistic regression analyses were used to identify factors associated with anxiety and depression.Results We collected the data from 992 persons in the final analysis. The estimated prevalence of poor sleep quality, anxiety, and depression was 71.4%, 11.1%, and 57.5% respectively. Poor sleep quality was positively correlated with both anxiety and depression. Between the two sleep quality groups, variables that showed significant differences included gender, marital status, education, comorbidity, occupation, COVID-19 healthcare work, and infection status (p < 0.05), but not fertility(p = 0.099).In the logistic regression analyses, divorce(or widow)(OR 4.115, 95%CI:1.361–12.441, p = 0.012),comorbidity(OR 1.879, 95%CI: 1.088–3.245,p = 0.024), and poor sleep quality(OR 13.417, 95%CI:4.189–42.97, p < 0.001) were identified as independent factors for anxiety. Bachelor's degree (OR 0.598, 95% CI: 0.373–0.959, p = 0.033), postgraduate or above degree (OR 0.555, 95%CI: 0.316–0.975, p = 0.041) and poor sleep quality (OR 2.438, 95%CI: 1.814–3.276, p < 0.001) were identified as independent factors for depression.Conclusions Under the new social environment, younger adults showed serious mental health problems, especially poor sleep quality and depression. Divorce (or widow), comorbidity, and poor sleep quality contribute to anxiety. Poor sleep quality was the risk factor for depression, while a bachelor’s or above degree served as a protective factor.