bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment Performance of Flexible Pavements for Surface Deflection Measure by Benkelman Beam Method
Authors: Jain Rohit , Alheety Mustafa A. , Rahul  , Sharma Jyoti , Saxena Anil Kumar 
Published: February 2023

AbstractThe condition of roads assumes significant part since it straightforwardly influence traveler just as cargo traffic. The decayed street having undesired diversion or deficient harshness makes inconvenience rider and may even bring about road mishaps. This insufficiency in road attributes can be classifications as both useful and underlying. The evaluation of street conditions is needed to distinguish the explanations behind disintegration before any restoration work is completed. The fundamental boundaries including in the appraisal of street conditions are avoidance and unpleasantness estimation which decided utilizing different test, for example, FWD, Benkelman shaft test, profilometer, and slide obstruction test. This appraisal additionally helps in focusing on the upkeep works as indicated by the necessity. A few procedures are utilized to evaluate the road conditions and contrast and standard standards. In this concentrate on a stretch of road is break down for similar where techniques utilized are visual strategy, Benkelman beam test, and slide opposition test. Utilizing last two methods, surface diversion and skid resistance is surveyed, and restorative measure are recommended for the road stretch.
Optoelectronic Study of Polymer Electrolyte Incorporated Perovskite Sensitized Solar Cell
Authors: Johari Rahul , Sonker Rakesh K. , Victor Okai , Khan Zishan H. , Aggarwal Daksh , Gupta Sandhya , Kumar Sushant 
Published: February 2023

AbstractPerovskite solar cells have appeared as a leading next‐generation photovoltaic technology. However, notwithstanding rolling efficiencies, many questions remain unreciprocated regarding the mechanisms and performance of the operation. Solution‐processed organic‐inorganic hybrid perovskites have fascinated attention as light‐harvesting materials for perovskite solar cells and photonic applications. The present study focuses on the optical and electronic study of CH3NH3PbBr3 and CH3CH2NH3PbI3 perovskite fabricated by a one‐step solution‐based self‐assemblage method. It is seen that in this study, methyl group represents a better performance than ethyl‐based perovskite‐sensitized solar cells (PSSCs). All the studies centralize on electro‐optical properties of efficient CH3CH2NH3PbI3 and CH3CH2NH3PbI3 PSSC based on polymer electrolytes. It has also characterized lab synthesized perovskite samples by scanning electron microscopy (SEM), UV–vis spectrophotometer, and photovoltaic performance of lab fabricated PSSC is measured by Keithley 2400 resource meter. These findings establish systematic strategy rules to attain silicon‐like efficiencies in simple perovskite solar cells.
Transfer of miR‐4755‐5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B
Authors: Lei Lei , Wang Yi , Liu Rui , Feng Jingjing , Tang Juan , Gou Junjie , Guan Feng , Li Xiang 
Published: February 2023

AbstractDecitabine (5‐aza‐2‐deoxycytidine, DAC), a DNA‐hypomethylating agent, has been one of the frontline therapies for clonal hematopoietic stem cell disorders, such as myelodysplastic syndrome and acute myeloid leukemia, but DAC‐resistance often occurs and leads to treatment failure. Therefore, elucidating the mechanisms of DAC resistance is important for improving its therapeutic efficacy. The extracellular vesicles and particles (EVPs) have been reported to be involved in mediating drug resistance by transporting diverse bioactive components. In this study, we established the DAC‐resistant cell line (KG1a‐DAC) from its parental human leukemia‐derived cell line KG1a and observed that EVPs released from KG1a‐DAC can promote DAC‐resistant in KG1a cells. Moreover, treatment with KG1a‐DAC EVPs reduced the expression of cyclin‐dependent kinase inhibitor 2B (CDKN2B) in KG1a cells. miRNA‐Seq analysis revealed that miR‐4755‐5p is overexpressed in EVPs from KG1a‐DAC. Dual‐luciferase reporter assay and flow cytometry analysis confirmed that miR‐4755‐5p rendered KG1a cells resistant to the DAC by targeting CDKN2B gene. Taken together, miR‐4755‐5p in EVPs released from the DAC‐resistant cells plays an essential role in inducing DAC‐resistance, and is a potential therapeutic target for suppression of DAC resistance.
Seismic passive earth pressure resistance for caisson in layered soil using modified pseudo‐dynamic approach
Authors: Kumar Mohit , Chatterjee Kaustav 
Published: February 2023

AbstractThe determination of seismic passive earth pressure resistance is of utmost importance during the analysis of geotechnical structures. In the present study, seismic passive earth pressure coefficient for caisson embedded in n‐layered soil is computed using modified pseudo‐dynamic method. Limit equilibrium method of analysis considering poly‐planar failure wedge has been adopted in the study and parametric variation of geometry of failure wedge has also been studied. The current study proposes formulation for variation of horizontal and vertical seismic acceleration profile with depth through various layers and studies the effect of number of layers, relative depths of various layers and relative soil friction angle in those layers, soil‐wall friction angle, horizontal and vertical seismic acceleration coefficients and normalized width of caisson. The study has been extended for submerged soil and the effect of excess pore pressure has been investigated. The results of the present study have been compared with previous theoretical studies and found to be in good agreement. It is observed that the extent of failure wedge formed in front of caisson increases with increasing soil friction angle, soil‐wall friction angle, horizontal seismic acceleration coefficient and width of caisson.
The role of the bladder diary in phenotyping men with LUTS
Authors: Khosla Lakshay , Lee Philip , Farooq Muhammad , Rychik Kevin , Daniel Roby , Vizgan Gabriel , Prishtina Learta , Bushman Wade , Weiss Jeffrey P. , Blaivas Jerry G. 
Published: February 2023

AbstractAimsThe aim of this study was to compare the clinical characteristics of men with lower urinary tract symptoms (LUTS) grouped by 24‐h urine output determined from a bladder voiding diary.MethodsAn online database was queried to identify men who completed a 24‐hour bladder diary (24HBD), and the Lower Urinary Tract Symptom Score (LUTSS) questionnaire from 2015 to 2019 using a mobile app. Data from the bladder diary and questionnaire were contemporaneously matched within a 2‐week period. Additional data, including maximum uroflow (Qmax) and postvoid residual urine (PVR), were obtained from the electronic medical record (EMR). The cohort was divided into three groups: normal, oliguria, and polyuria based on their 24‐hour voided volume (24HVV). The LUTSS, 24HVV, maximum voided volume (MVV), maximum flow rate (Qmax), and PVR were compared between those with oliguria and polyuria.ResultsA total of 327 men (mean age 62, SD: 19) completed the LUTSS questionnaire and contemporaneous 24HBD. Of these, 61% had a normal 24HVV, 13% had oliguria, and 26% had polyuria. A total of 147 patients from the study cohort had contemporaneous Qmax and PVR abstracted from the EMR. There was no difference in symptom severity, bother, or PVR among the three patient groups. However, several objective metrics were significantly correlated with urine output. Men with oliguria, as compared to men with polyuria were older (65 vs. 55 years) and had lower MVV (260 vs. 470 mL), fewer voids/24 h (8 vs. 13), and lower Qmax (8.5 vs. 18.3 mL/s).ConclusionsThese observations suggest that men with oliguria or polyuria and LUTS constitute easily distinguished phenotypes that might require different diagnostic and therapeutic algorithms. Those with oliguria were older, and had lower MVVs and much lower uroflows, suggesting that they are more likely to have underlying disorders such as bladder outlet obstruction and detrusor underactivity or may be patients with overactive bladder who reduced fluid intake to improve symptoms.
Checklist to assess food safety when handling home enteral nutrition
Authors: da Costa Rayane Luizi , Medeiros Caroline Opolski , da Cunha Diogo Thimoteo , Stangarlin‐Fiori Lize 
Published: February 2023

AbstractBackgroundIdentifying food safety risks when handling enteral formulations at home is important to restore and maintain the health of patients. Therefore, this study developed and validated a food safety assessment checklist for handling home enteral nutrition (HEN).MethodsThis methodological study developed a checklist based on a literature review and interviews with food safety professionals. The content validation, which was conducted by food safety and enteral feeding experts, assessed the relevance, clarity, and simplicity of the checklist using the content validity index of items (CVI‐I), categories (CVI‐C), and the entire instrument (CVI‐EI). Each item was rated as either essential, necessary, or recommended according to the risk in relation to foodborne diseases.ResultsThe Food Safety for Handling Home Enteral Nutrition checklist (FSHEN checklist) that was developed includes 40 items and the following eight categories: physical structure; cleaning of facilities, equipment, furniture, and utensils; pests and waste; water supply; food handlers; ingredients and packaging; handling of enteral formulations; and the bottling and storage of enteral formulations. The CVI‐EI was above the recommendation (≥0.93) for the three assessed criteria, as was the CVI‐C in terms of clarity (≥0.95), relevance (≥0.98), and simplicity (≥0.84). A total of 52.5% of the items were rated as essential, 32.5% as necessary, and 15% as recommended.ConclusionThe FSHEN checklist is relevant, clear, and easy to use. It can help health professionals and individuals working in the field to assess and prioritize items to improve food safety in the management of HEN.
Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate
Authors: Popovics Petra , Skalitzky Kegan O , Schroeder Elise , Jain Asha , Silver Samara V , Van Fritz Francesca , Uchtmann Kristen S , Vezina Chad M , Ricke William A 
Published: February 2023

AbstractBenign prostatic hyperplasia (BPH) occurs progressively with aging in men and drives deteriorating symptoms collectively known as lower urinary tract symptoms (LUTS). Age‐associated changes in circulating steroid hormones, and prostate inflammation have been postulated in the etiology of BPH/LUTS. The link between hormones and inflammation in the development of BPH/LUTS is conflicting because they may occur independently or as sequential steps in disease pathogenesis. This study aimed to decipher the prostatic immune landscape in a mouse model of lower urinary tract dysfunction (LUTD). Steroid hormone imbalance was generated by the surgical implantation of testosterone (T) and estradiol (E2) pellets into male C57BL/6J mice and gene expression analysis was performed on ventral prostates (VPs). These experiments identified an increase in the expression of macrophage markers and Spp1/osteopontin (OPN). Localization studies of OPN pinpointed that OPN+ macrophages travel to the prostate lumen and transition into lipid‐accumulating foam cells. We also observed a significant increase in the number of tissue macrophages in the VP which was prevented in OPN‐knockout (OPN‐KO) mice. In contrast, mast cells, but not macrophages, were significantly elevated in the dorsal prostate of T + E2‐treated mice which was diminished in OPN‐KO mice. Steroid hormone implantation progressively increased urinary frequency, which was ameliorated in OPN‐KO mice. Our study underscores the role of age‐associated steroid hormone imbalances as a mechanism of expanding the prostatic macrophage population, their luminal translocation, and foam cell differentiation. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Online micro solid phase extraction coupled with ultra‐performance liquid chromatography–tandem mass spectrometry for trace analysis of endogenous plant hormones in Ulva linza
Authors: Li Yuxuan , Duan Chunfeng , Ning Haijing , Ni Lanxiu , Li Jiamin , Gao Yan , Ding Kun , Guan Yafeng 
Published: February 2023

AbstractObjectiveUlva linza (L.) is a species of green algae widely distributed in China. We aimed to establish a sensitive online analytical method for quantification of endogenous phytohormones in fresh minute seaweed samples.MethodThe method for quantification of endogenous plant hormones in fresh minute samples was developed based on a homemade online micro solid phase extraction (m‐SPE) system coupled with an ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) platform. The online m‐SPE instrument injected the eluent of m‐SPE directly onto the LC separation column, improving the utilization of samples and saving time. The m‐SPE column, of which the effective size was 9.6 × 2 mm i.d., was filled with 19 mg of C18 (10 μm).ResultsUnder optimized conditions, the limits of detection were 0.002–0.060 ng ml−1 for five plant hormones. The actual sample recoveries of phytohormones were 76.4–103.4% and the coefficients of variance were below 14.1%. The temporal distribution of these endogenous plant hormones of U. linza during different growth periods is described.ConclusionThe proposed online m‐SPE method was successfully applied to quantification of endogenous acidic and alkaline plant hormones in U. linza. It provides important information for the further study of the physiological and ecological effects of plant hormones in lower algal species.
New ways of using old antibiotics in pediatrics: Focus on fosfomycin
Authors: Tran Martin Tuan 
Published: February 2023

AbstractFosfomycin, originally named phosphonomycin when it was first isolated from fermentation broth of Streptomyces species and synthesized at Merck in 1969. The phosphonic acid containing a structurally strained and reactive epoxide ring confers broad spectrum, bactericidal activity against gram‐positive and gram‐negative bacteria. Fosfomycin's small size and hydrophilicity permits broad tissues penetration. Although only fosfomycin tromethamine oral is approved for urinary tract infections (UTI) in the United States since 1996, the intravenous form has been utilized worldwide for over four decades. The increasing rates of multidrug‐resistant (MDR) infections with few novel treatment options available has spurred the recent interest in fosfomycin. Fosfomycin's high urinary concentration, broad spectrum of activity against MDR pathogens, and favorable safety profile offers a valuable oral option for treating UTI, one of the most common bacterial infections in childhood. The ability of fosfomycin to penetrate biofilm and reported activity against intracellular pathogens may further its importance in childhood diseases such as Chronic Granulomatous Disease, Salmonellosis, and Listeriosis. More data are needed to further define optimal Pharmacodynamic target, as well as Pharmacokinetic, safety and outcomes for repeated oral and intravenous dosing of fosfomycin in infants and children in systemic infections.
Review of novel β‐lactams and β‐lactam/β‐lactamase inhibitor combinations with implications for pediatric use
Authors: Olney Katie B. , Thomas Jenni K. , Johnson Wes M. 
Published: February 2023

AbstractAntimicrobial resistance continues to surmount increasing concern globally, and treatment of difficult‐to‐treat (DTR) Pseudomonas aeruginosa, carbapenem‐resistant (CR) Acinetobacter baumannii (CRAB), and CR Enterobacterales (CRE) remains a challenge for clinicians. Although previously rare, the incidence of multidrug‐resistant (MDR) and CR infections in pediatric patients has increased drastically in the last decade and is associated with increased morbidity and mortality. To combat this issue, 14 novel antibiotics, including three β‐lactam/novel β‐lactamase inhibitor combinations (βL‐βLIs) and two novel β‐lactams (βLs), have received approval from the United States Food and Drug Administration since 2010. Improving clinician understanding of the utility of these novel therapies is imperative to improve judicious decision‐making and prevent societal regression to a pre‐penicillin era. In this review, we summarize the pharmacokinetic/pharmacodynamic (PK/PD) properties, clinical efficacy and safety data, dosing considerations, and subsequent role in therapy for ceftazidime‐avibactam (CAZ‐AVI), meropenem‐vaborbactam (MER‐VAB), imipenem‐cilastatin‐relebactam (IMI‐REL), ceftolozane‐tazobactam (TOL‐TAZ), and cefiderocol in pediatric patients.
The long‐term outcomes of symptomatic congenital lobar emphysema patients
Authors: Gatt Dvir , Lapidus‐Krol Eveline , Chiu Priscilla P. L. 
Published: February 2023

AbstractIntroductionSurgical (OP) management for symptomatic congenital lobar emphysema (CLE) is the standard of care with nonoperative (NOP) approach applied for asymptomatic cases. The aim of this study is to report the outcomes for NOP approach to the care of symptomatic CLE infants.MethodsA retrospective study of CLE patients treated 2000−2021 at a single institution. Patients with CLE and respiratory symptoms were included.ResultsOverall, 23 children had symptomatic CLE, and 12 had NOP management. The median age at diagnosis was 38.5 days (50) in the NOP group versus 25 days (20) in the OP group (p = 0.31). There was no significant difference in the location of the involved lobe, term birth, postnatal diagnosis and gender, and both groups required noninvasive support in 33% of the cases. There was a trend towards higher frequency of oxygen support in the OP group preoperatively (89% vs. 42%, p = 0.07). The median length of stay was 14 days in the NOP group compared to a median postsurgery stay of 7.5 days in the OP group. In follow‐up, there was no significant difference in respiratory readmission in first year of life, growth delay, treatment with asthma medication or body mass index in the NOP versus OP group. None of the children in the NOP group required surgery during follow‐up.ConclusionsA NOP approach for symptomatic CLE infants can have favorable long‐term outcomes. Further studies will be required to identify markers to aid in clinical decision‐making.
Detonation performance of urea‐hydrogen peroxide (UHP)**
Authors: Halleux Francis , Pons Jean‐François , Wilson Ian , Simoens Bart , Van Riet Romuald , Lefebvre Michel 
Published: February 2023

AbstractCarbamide Peroxide, an adduct of Urea and Hydrogen Peroxide, is commonly used in the cosmetic and pharmaceutical industries as a solid source of hydrogen peroxide. However, it exhibits explosive properties and can be easily manufactured from readily available household chemicals, making it a potential emerging threat. We carried out a detailed performance assessment, combining experiments, thermochemical calculations and numerical simulations and highlighted a good level of agreement between experimental data from lab, field and underwater firings. A maximum detonation velocity of 3.65 km/s was recorded for unconfined 25 kg UHP charges at 0.85 g/cm3(200 mm charge diameter). We determined in these conditions an infinite diameter detonation velocity of 3.94 km/s. These results are also consistent with previous results obtained at small scale under heavy confinement. Airblast measurements highlighted an average 40 % TNT equivalence for impulse and 55 % for peak overpressure at short distance, which are in good agreement with the 57 % (Power Index) calculated from Explo5, while 50 % for bubble energy (explosive power) and 20 % for shock pressure (brisance) were obtained from underwater experiments. The use of different experimental approaches has proven useful to characterise the performances parameters of a non‐ideal explosive for risk assessment purposes.
Early physiotherapy management of patients with Covid‐19 admitted to a university hospital in Norway (March 2020 to July 2021)
Authors: Nilsson Birgitta Blakstad , Bø Elisabeth 
Published: February 2023

AbstractAimThe aim of this retrospective observational study was to describe the scope of physiotherapy, the population and the physiotherapy management of Covid‐19 patients referred to physiotherapy at a university hospital in the period from March 2020 to July 2021.MethodA descriptive observational study with access to data from a quality register, which contains clinical data of all patients admitted with Covid‐19 to a university hospital in Norway. Data was obtained from electronic data sheets, where daily parameters for physiotherapy treatment were registered.ResultsIn total, 729 Covid‐19 patients were admitted during this period. Of these, 507 (69.6%) received treatment by a physiotherapist (3510 sessions). The physiotherapy treatments were performed on intensive care units (ICU) (50%), intermediate care units (11%) and general medical units (39%), respectively. Patients were mainly treated during the day (98.5%) and 21% of the sessions were given on weekends or holidays. Within the 3510 sessions, 9459 interventions were performed in total (one to seven interventions per session). The most common intervention provided was positioning (35.4%). The most common interventions in medical units and intermediate care units were training with a positive expiratory pressure device (17.3% and 15.9% respectively), and techniques for reducing work of breathing (13% and 15% respectively). The most common intervention in the ICUs was passive mobilization (21.3%), mostly in combination with positioning, manual techniques and/or airway clearance.ConclusionThis study provides characteristics of, and experiences with early physiotherapy, in sequentially hospitalized patients at a university hospital in Norway.
Probing HNL‐ALP Couplings at Colliders
Authors: de Giorgi Arturo , Merlo Luca , Tastet Jean‐Loup 
Published: February 2023

AbstractAxion‐like particles (ALPs) and heavy neutral leptons (HNLs) are both well‐motivated extensions of the Standard Model. As ALPs couple to on‐shell fermions proportionally to their masses, processes involving both types of particles may give rise, for TeV HNLs, to relevant phenomenology at colliders. In this work, we point out a particularly clean process, whose final state consists of four jets and two charged leptons, and we estimate its current and future sensitivity at the LHC. For on‐shell HNLs, i) there is no dependence on the overall scale of the mixing between HNLs and the active neutrinos, making this process sensitive down to the type‐I Seesaw line; ii) the signal strength of the process is sizable only as far as the HNL masses are below a few TeVs, contrary to what the proportionality to masses of the ALP couplings may suggest. Although ALPs and HNLs have been mainly studied independently in the literature, considering their interplay may lead to joint limits that are much stronger than those on the individual particles taken separately. This concise study paves the way for similar searches at colliders and other experiments.