bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nurses’ Job Satisfaction in Public Hospitals in Addis Ababa
Authors: Haile Elias Sebsibe 
Published: August 2023

Abstract
Job satisfaction largely determines the productivity and efficiency of human resource for health. It literally depicts the extent to which professionals like or dislike their jobs. Job satisfaction is said to be linked with different personal and organizational factors affect employee’s organizational commitment and consequently the quality of services. The objective of the study is to determine the level of and factors influencing job satisfaction among nurses’ in public hospitals in Addis Ababa city administration. Cross-sectional descriptive survey research design will be used to gather information from the targeted population without creating contradiction. To determine the size of sample the researchers will use single population proportion formula with the assumption of 95% confidence level. The sample size is 333. Self-administrated survey questionnaires will be used to collect data from respondents. The study revealed that the level of job satisfaction of nurses in public hospitals of Addis Ababa were very low. The factors that related with low job satisfaction are mainly related to salary and benefited, lack of growth and development and training. Low involvement in decision making process and lack of administrative support were other strong factors of low job satisfaction.
Manipulating Moiré Excitons in Two-Dimensional Quantum Systems via Optical Microcavities
Authors: LIU Yanping , Zheng Haihong , Wu Biao , Li Shaofei , Ding Junnan , He Jun , Liu Zongwen , Zhang Shunping , Duan Xidong , Pan Anlian , Wang Jian-Tao 
Published: August 2023

Abstract
Moiré-trapped interlayer excitons within two-dimensional (2D) moiré superlattices offer a remarkably versatile and adaptable platform, enabling an extensive exploration of dipole interactions and many-body correlations in the realm of 2D quantum systems. Conversely, optical microcavities, capable of confining photons within a confined space, profoundly amplify the interplay between light and matter, ushering in a new era of possibilities for photonics research. However, the intricate synergy between moiré potential and optical microcavities remains shrouded in uncertainty. Here, we present a precise integration of a twisted WSe2/WSe2 homobilayer with an optical microcavity, forging a cooperative alliance between moiré excitons and microcavity photons. Our investigation unveils highly localized moiré-enhanced emission in the suspended WSe2/WSe2 homobilayer, distinguished by remarkably sharp emission lines with peak widths reduced by a factor of three, alongside distinctive valleytronic attributes. Notably, our pioneering work uncovers a profound transformation in the nature of moiré exciton-dipole interactions within the suspended twist-angle WSe2/WSe2 homobilayer. This transformation triggers an unprecedented shift from repulsive to attractive interactions, culminating in the emergence of a robust moiré biexciton phase—an occurrence previously confined to theoretical predictions. Our findings provide essential insights into the cooperative interplay between moiré excitons and optical microcavities, illuminating the underlying physics and charting a course for future research and technological advancements in this captivating realm.
Fiber Reinforced White Topping as a Rehabilitation Alternative over Flexible Pavement: An Experimental Study on Awash-Mille Road
Authors: Tsahay Urji , Garoma Shiferaw 
Published: August 2023

Abstract
White topping is a rehabilitation treatment on asphalt concrete. This is one of the rehabilitation method believed by many researchers to lower maintenance cost of the pavement with very good performance result. It is increasing both in developed and developing countries; but the concept is new and have not been applicable in Ethiopia. In Ethiopia, asphalt overlay is the dominant type of rehabilitation measure to restore bituminous pavement distresses. Ethiopian Roads Authority (ERA) is currently maintaining the road from Awash to Mille which had experienced rutting, fatigue and thermal cracking. The road was designed for critical period of 5 years for rehabilitation with overlay thickness ranging from 50 mm to 120 mm. Some of the section experienced rutting and fatigue cracking within 1 to 2 years after it had been constructed. The research study utilized experimental evaluation to achieve the objectives on 1 km length of the selected segment. Field testing was carried out using Benkelman Beam Deflection equipment to assess the structural situation of existing asphalt. The deflection & modulus of sub grade reaction result indicates that the severity of the rutting would not be associated to the overall strength of the roadway as indicated by its very low deflection. Laboratory testing was accomplished to determine the optimum plastic percentage mixed in the concrete as fiber reinforcement. The result indicates that adding of shredded plastic with plastic fiber of 0.25% weight of cement improves both compressive and tensile strength of concrete. The 28th day for compressive strength and split tensile strength was increased by 1.08% and 5.53% respectively. Therefore, adding amount of 1.063 kg per m3 in white topping improved shrinkage and cracking which is the drawback of normal concrete. Using input from field and laboratory test result white topping thickness had been designed using Bonded Concrete Overlay of asphalt Mechanistic-Empirical design tool as rehabilitation alternative for the deteriorated flexible pavements. Finally, an attempt was made to compare initial construction cost of Fiber reinforced white topping with that of conventional flexible overlay designed by ERA. From the assessment of the study, early construction cost of white topping with 127 mm thickness was greater in 872368.8 ETB than 55 mm thickness of asphalt overlay designed by ERA. Therefore, it is necessary to construct a few trial section using local materials, traffic and climatic conditions to check its performances.
Similar but different: characterization of dddD gene mediated dimethylsulfoniopropionatemetabolism among Coral-Associated Endozoicomonas
Authors: Chiou Yu Jing , Chan Ya-Fan , Yu Sheng-Ping , Lu Chih-Ying , Sung-Yun Silver , Chiang Pei-Wen , Hsu Ting-Chang , Liu Po-Yu , Wada Naohisa , Lee Yu , Jane Wann-Nng , Lee Der-Chuen , Huang Yu-Wen , Tang Sen-Lin 
Published: August 2023

Abstract
Endozoicomonas, the predominant bacterium associated with corals, is believed to play crucial roles in maintaining coral health. Its role in dimethylsulfoniopropionate (DMSP) degradation has been a subject of discussion for over a decade. A previous study found Endozoicomonas degraded DMSP through dddD pathway. This process releases dimethyl sulfide (DMS), which is vital for corals coping with thermal stress. However, little is known about the related gene regulation and metabolic abilities of DMSP metabolism in Endozoicomonadaceae. In this study, we observed a distinct DMSP metabolic trend in two phylogenetically close dddD -harboring Endozoicomonas species confirming genetically by the comparative transcriptomic profiling and visualizing the change of DMSP stable isotopes in bacterial cell using NanoSIMS. Furthermore, we found that DMSP cleavage enzymes are ubiquitous in coral Endozoicomonas with a preference for possessing DddD lyase. We speculate harboring DMSP degrading genes enables Endozoicomonas to successfully colonize various coral species across the globe.
Teaser: Coral-associated Endozoicomonas are widespread DMSP degraders monopolized by the dddD gene, employing various degradation mechanisms.
Analysis of Genetic Variability, Heritability and Genetic Advance for Yield and Yield Associated Traits in Rice (Oryza Sativa L.)
Authors: Kumar Rajneesh , Ram Mukh , Heera Prashanth Kumar , Murali S. , kumar Arun Sai 
Published: August 2023

Abstract
The present investigation was conducted using 27-rice germplasm for the thirteen traits studied at the agriculture research farm, Department of Genetics and Plant Breeding, School of Agriculture, Lovely Professional University, Punjab during the kharif season 2022. A Randomized Block Design (RBD) with three replications were used to study genotypic and phenotypic variances, heritability, GCV, PCV, genetic advance, and genetic advance as a percentage of the mean (GAM %) for all the yield contributing traits. Harvest index recorded highest GCV (23.56) and PCV (25.06) respectively while Single plant yield had highest heritability h2 (92.11 %). However, Number of spikelets per panicle (45.60), number of filled grains per panicle (32.65), plant height (20.81) had high genetic advance. Moreover, Harvest index (45.64) had highest genetic advance as percent mean (GAM).
LINC1521 and miR-3679-5p modulate cellular response to chemical stress in breast cancer patients through regulation of XBP1 expression as a potential diagnostic biomarker
Authors: Shirdeli Sayedeh Zahra , Hashemi Seyedeh Aramdokht , hashemi Ghazaleh sadat , khalilian Leyli , Ferdowsian Shaghayegh , Mostaghimi Yasaman , Rezaei Mohammad , Azadeh Mansoureh 
Published: August 2023

Abstract
Background
The majority of breast cancer (BC) patients die of metastasis rather than primary tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly understood. Long noncoding RNAs (lncRNA) have been shown to regulate cancer occurrence and progression. However, the lncRNAs that drive metastasis in cancer patients and their underlying mechanisms are still largely unknown. In this study, expression, interaction, and related pathways of XBP1 and a novel regulatory non-coding RNA, LINC01521 is evaluated in BC patients.
Methods
Microarray data analysis was performed using R Studio (4.1.2). GSE71052 was used in this study. miRNA interaction analysis carried out using miRWalk. lncRNA-mRNA interaction analysis was conducted using lncRRIsearch. Expression and survival analysis was performed by GEPIA2. Illustration of interaction analyses was performed by cytoscape. The qRT-PCR experiment was performed for the validation of expression results.
Results
XBP1 (logFC:, p-value: ) and LINC01521 (logFC:, p-value: ) have significant up-regulation in BC and could be the two potential diagnostic biomarker of BC. Up-regulation of XBP1 observed in bioinformatics analyses and supported by experimental results in this study. XBP1 regulates the function of HMOX1 in cellular response to chemical stress signaling pathway. miR-3679-5p suppresses the expression level of XBP1 (energy: -30.5, score: 1, position: 3’UTR). XBP1 also involved in Response To Interleukin-4 (GO:0070670) and Positive Regulation Of B Cell Differentiation (GO:0045579) biological processes.
Conclusion
miR-3679-5p as a novel miRNA and LINC01521 as a potential oncogene and diagnostic biomarker might modulate cellular response to chemical stress signaling pathway in BC patients through regulation of XBP1, a BC oncogene.
Mapping regional and nested flow systems in the karst aquifers of Jinan spring using hydrochemical and isotope data
Authors: Deng Xing , Xing Liting , Zhang Fengjuan , Xing Xuerui , Zhang Yunfeng , Yu Miao , Liu Suozhu , Pan Weiyan 
Published: August 2023

Abstract
This study enhances the understanding of the evolution of water transport in karst water flow systems. This paper explores the karst water flow system from a hydrogeochemical perspective. It has been discovered that in the recharge area, the hydrochemical effect of karst water is primarily influenced by dissolution and filtration. In the fault zone and concentrated discharge area, it is primarily influenced by mixing. In the geothermal area, the dominant factors are dissolution, precipitation, and dolomitization. From the southern to the northern area, the hydrochemical type of karst water gradually changes from HCO3-Ca type to SO4·Cl-Ca·Na type. Atmospheric precipitation is the primary recharge source of karst water, with a recharge elevation range of 181–1,495 m. According to geological drilling statistics, the groundwater transport depth transits from the shallow transport in the south to the deep transport in the north, with a depth range of 3,000–3,500 m, and using isotope data to obtain the groundwater retention time range is 6–27,000 years. The groundwater transport mode is divided into three levels: open-shallow transport karst cold water phreatic flow, semi-open-medium-deep transport karst cold water confined flow, and weak open-deep transport geothermal water confined water flow.
Retracted: The application of nanoparticles on the yield and nutritional quality of rice under different irrigation regimes
Authors: Zarei Mehrnaz , Fallah Hormoz , Niknejad Yosoof , Tari Davood Barari 
Published: August 2023

Abstract
The amino acid profile in rice serves as an indicator of its nutritional worth, playing a significant role in evaluating its overall nutritional quality. However, there has been limited research on how nanoparticles (NPs) and various irrigation regimes affect the nutritional value and overall quality of rice. In the present study, the effects of different irrigation regimes and foliar spray of NPs on the yield, nutrient concentration, and amino acid profile of milled rice in two rice cultivars were evaluated. The results showed that the Shirodi cultivar had a higher yield and nutrients compared to the Hashemi cultivar. Reducing irrigation significantly lowered the grain yield, nutrient elements, and some amino acids (asparagine, glutamic acid, serine, alanine, histidine, and arginine) in milled rice while increasing other amino acids. However, NPs treatments, especially ZnONPs + SiO2NPs treatment, increased grain yield and amino acids in milled rice. Regarding mineral nutrients, SiO2NPs and ZnONPs + SiO2NPs treatments decreased mineral nutrients in milled rice, while ZnONPs treatment increased Ca, Fe, Mg, and N and decreased the content of other elements in milled rice. Therefore, our findings showed that SiO2NPs and ZnONPs are promising NPs that can improve the yield and nutritional quality of milled rice, especially in water-deficient conditions.
Expression and Regulatory Roles of Small Nucleolar RNA Host Gene 4 in
Gastric Cancer
Authors: Pourghasem Navid , Ghorbanzadeh Shadi , Nejatizadeh Azim 
Published: August 2023

Aims:
The role of SNHG4 in the initiation and development of gastric cancer.

Background:
Gastric cancer is one of the leading causes of cancer death worldwide. Studies have
shown that lncRNAs have a regulatory function in human diseases, particularly cancers. Small nuclear
RNA host gene 4 (SNHG4) has been known as an oncogenic long noncoding RNA (lncRNA)
in various cancers, and its dysregulation can lead to tumorigenesis and cancer progression.

Objective:
Alteration of SNHG4 expression in gastric cancer and its correlation with clinical features
of patients with stomach cancer; also, the accomplishment of bioinformatic analysis to find
the potential pathways which could be impressed by changes in SNHG4 RNA expression.

Methods:
The present study aims to determine the molecular mechanism of SNHG4 and the effects
of its expression on the development of GC. Based on the bioinformatics investigations, we studied
gene expression analysis, Kaplan-Meier survival, Gene ontology (GO), KEGG pathway enrichment,
microRNA targets, transcription factor targets, and proteins interacting with SNHG4. During
the experimental phase, SNHG4 expression was examined by quantitative real-time PCR (qRTPCR)
in 40 paired gastric adenocarcinoma tissues and normal neighboring tissues. Also, we investigated
the correlation between SNHG4 expression and patients' clinicopathological characteristics.

Results:
Increased SNHG4 expression was detected in GC tissues, which is significantly associated
with the TNM stage, grade group, tumor size, and metastatic status. Evaluation survival analysis
demonstrated that overexpression of SNHG4 in GC tissues is remarkably related to poor overall
survival (OS). SNHG4 is closely related to miR-490 and E2F family transcription factors. GO analysis
suggested the possible role of SNHG4 in cell-cell adhesion, and KEGG enrichment analysis revealed
that SNHG4 could be associated with the gastric cancer signaling pathway. ELAVL1 and
IGF2BP2 have the highest number of SNHG4 target sites, and these proteins are involved in the
PI3K-Akt-mTOR and ERK-MAPK signaling pathways.

Conclusion:
Based on our results, we conclude that SNHG4 may have a function in GC development
by regulating tumor-related signaling pathways.
A Novel Etanercept-loaded Nano-emulsion for Targeted Treatment of
Inflammatory Arthritis via Draining Lymph Node
Authors: Li Chenglong , lu Guanting , Jiang Yue , Su Huaiyu , Li Chen 
Published: August 2023

Background:
Rheumatoid arthritis (RA) is a systemic autoimmune disease (AD), and the
global incidence rate is 0.5 ~ 1%. Existing medications might reduce symptoms, however, there is no
known cure for this illness. Etanercept (EN) can competitively inhibit TNF-α binding to the TNF receptor
on the cell surface to treat RA. However, subcutaneous injection of free EN predisposes to systemic
distribution and induces immune system hypofunction. Draining lymph nodes (LNs) play a significant
role in the onset, maintenance, and progression of RA as they are the primary sites of aberrant immune
response and inflammatory cytokine production.

Aim:
The purpose of this study was to successfully treat RA with etanercept by encapsulating it in nanoemulsions
(NEs/EN) and then delivering it specifically to draining LNs. The EN-loaded NEs were prepared
by high-pressure homogenization method and modified with DSPE-mPEG2000 and Ca(OH)2.

Methods:
A novel nano-emulsion (NE) was constructed to deliver EN (NE/EN) to RA-draining LNs. To
decrease aggregation and load EN, DSPE-mPEG2000 and Ca(OH)2 were successively decorated on the
surface of the lipid injectable emulsions. The hydrodynamic diameter and morphology of NEs/EN were
investigated by using a laser particle size analyzer and transmission electron microscopy, respectively.
The in vivo fluorescence imaging system was used to study the in vivo LN targeting ability of the formulation.
In the therapeutic experiment, NEs/EN was subcutaneously administrated to inhibit the development
of the mouse arthritis model.

Results:
Circular dichroism spectrum and L929 cell experiment confirmed that NEs encapsulation had
no impact on the biological activity of EN. In vivo investigation on collagen-induced arthritis (CIA)
mouse model showed that NEs/EN have good inguinal lymph node targeting capabilities, as well as,
anti-inflammatory effect against RA. Compared with the free group, the paw thickness and arthritic
score in NEs/EN group were significantly alleviated. Moreover, the concentration of pro-inflammatory
cytokines TNF-α and IL-1β in NEs/EN-treated mice was lower than that in free EN.

Conclusion:
NEs/EN effectively improve the effectiveness of EN in the treatment of RA. Our work
provides an experimental foundation for expanding the clinical application of EN.
The Basal Ganglia Downstream Control of Action – An Evolutionarily
Conserved Strategy
Authors: Frost-Nylén Johanna , Thompson William Scott , Robertson Brita , Grillner Sten 
Published: August 2023

Abstract:
The motor areas of the cortex and the basal ganglia both contribute to determining which
motor actions will be recruited at any moment in time, and their functions are intertwined. Here, we
review the basal ganglia mechanisms underlying the selection of behavior of the downstream control
of motor centers in the midbrain and brainstem and show that the basic organization of the forebrain
motor system is evolutionarily conserved throughout vertebrate phylogeny. The output level of the basal
ganglia (e.g. substantia nigra pars reticulata) has GABAergic neurons that are spontaneously active
at rest and inhibit a number of specific motor centers, each of which can be relieved from inhibition if
the inhibitory output neurons themselves become inhibited. The motor areas of the cortex act partially
via the dorsolateral striatum (putamen), which has specific modules for the forelimb, hindlimb, trunk,
etc. Each module operates in turn through the two types of striatal projection neurons that control the
output modules of the basal ganglia and thereby the downstream motor centers. The mechanisms for
lateral inhibition in the striatum are reviewed as well as other striatal mechanisms contributing to action
selection. The motor cortex also exerts a direct excitatory action on specific motor centers. An
overview is given of the basal ganglia control exerted on the different midbrain/brainstem motor centers,
and the efference copy information fed back via the thalamus to the striatum and cortex, which is
of importance for the planning of future movements.
Mutation S249C of FGFR3b Promotes Bladder Cancer through Downstream
Signaling Proteins FRS2 and FRS3: A Computational Approach
Authors: Ali Aisha , Lateef Alwisha , Waheed Zuha , Waseem Mishal , Zaheer Tahreem , Gomez Miriam K , Blaheta Roman , Justin Saira 
Published: August 2023

Background:
Bladder cancer is the 9th most prevalent malignancy worldwide. Fibroblast
Growth Factor Receptor 3b (FGFR3b), involved in cell proliferation, differentiation, and migration,
is a mutations hotspot for bladder cancer with the most prevalent aberration being S249C.

Objective:
Impact of S249C of FGFR3b on bladder tumorigenesis via immediate downstream adapter
proteins, Fibroblast Growth Factor Receptor Substrate (FRS2 and FRS3) is analyzed computationally.

Methods:
Wildtype FGFR3b monomer was modeled using I-TASSER and Phyre2. Whereas,
S249C mutation was introduced via DynaMut. Wildtype FGFR3b homodimer and mutant heterodimer
were structured and docked with downstream proteins using HADDOCK. PDBSum was
used to study the amino acid residues involved in intermolecular and intramolecular interactions.

Results:
Parameters of molecular flexibility and interatomic interactions predicted S249C heterodimer
mutation of FGFR3b to be stable. Furthermore, docking with FRS2 protein revealed greater
stability and higher binding affinity for S249C heterodimer mutant compared to wildtype homodimer.
However, FRS3 docking showed a negligible decline in binding affinity for the S249C mutation
but based on Van der Waal’s energy and insights into the interacting residues, it was revealed
that these interactions might be stronger and for longer duration in comparison to the wildtype homodimer.

Conclusion:
S249C heterodimer mutation of FGFR3b is predicted to be stable with a tumorigenic
potential where FRS2 and FRS3 might be among the key players of altered downstream signaling.
Further investigations are required for a detailed picture.