bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drought responsiveness in six wheat genotypes: identification of stress resistance indicators
Authors: Guizani Asma , Askri Hend , Amenta Maria Laura , Defez Roberto , Babay Elyes , Bianco Carmen , Rapaná Nicoletta , Finetti-Sialer Mariella , Gharbi Fatma 
Published: September 2023

IntroductionWheat (Triticum aestivum L.) is among the world’s most important staple food crops. In the current climate change scenario, a better understanding of wheat response mechanisms to water stress could help to enhance its productivity in arid ecosystems.MethodsIn this study, water relations, gas exchange, membrane integrity, agronomic traits and molecular analysis were evaluated in six wheat genotypes (D117, Syndiouk, Tunisian durum7 (Td7), Utique, Mahmoudi AG3 and BT) subjected to drought-stress.Results and discussionFor all the studied genotypes, drought stress altered leaf area, chlorophyll content, stomatal density, photosynthetic rate and water-use efficiency, while the relative water content at turgor loss point (RWC0) remained stable. Changes in osmotic potential at turgor loss point (Ψπ0), bulk modulus of elasticity (Ɛmax) and stomatal regulation, differed greatly among the studied genotypes. For the drought-sensitive genotypes AG3 and BT, no significant changes were observed in Ψπ0, whereas the stomatal conductance (gs) and transpiration rate (E) decreased under stress conditions. These two varieties avoided turgor loss during drought treatment through an accurate stomatal control, resulting in a significant reduction in yield components. On the contrary, for Syndiouk, D117, Td7 and Utique genotypes, a solute accumulation and an increase in cell wall rigidity were the main mechanisms developed during drought stress. These mechanisms were efficient in enhancing soil water uptake, limiting leaf water loss and protecting cells membranes against leakage induced by oxidative damages. Furthermore, leaf soluble sugars accumulation was the major component of osmotic adjustment in drought-stressed wheat plants. The transcriptional analysis of genes involved in the final step of the ABA biosynthesis (AAO) and in the synthesis of an aquaporin (PIP2:1) revealed distinct responses to drought stress among the selected genotypes. In the resistant genotypes, PIP2:1 was significantly upregulated whereas in the sensitive ones, its expression showed only a slight induction. Conversely, the sensitive genotypes exhibited higher levels of AAO gene expression compared to the resistant genotypes. Our results suggest that drought tolerance in wheat is regulated by the interaction between the dynamics of leaf water status and stomatal behavior. Based on our findings, Syndiouk, D117, Utique and Td7, could be used in breeding programs for developing high-yielding and drought-tolerant wheat varieties.
Nutrition regulates sex expression in a gender diphasy plant, Lilium concolor var. megalanthum
Authors: Chen Xin , Wang Lei , Yan Xingfu , Tang Zhanhui 
Published: September 2023

IntroductionThe evolution and maintenance of plant polymorphism have always received much attention. Gender diphasy is a rare sexual system. Plant individuals with gender diphasy can adjust the resource allocation of different functional organs according to the changes of environmental conditions to regulate the sex expression of individuals, and the sex expression can be converted between years. However, our understanding of sex expression in plants is still very insufficient. In this study, we explored whether the perennial plantLilium concolorvar.megalanthumhas a gender diphasy system and whether environmental resource availability affects its resource allocation and sex expression.MethodBy collecting the bulbs of two sexual phenotypes (male and hermaphrodite) in the field and simulating the application of different levels of nutrients under the same habitat conditions, the growth and reproduction indexes and sex expression of plants in two years (2021 and 2022) were measured to evaluate the resource allocation strategy and sex expression pattern ofLilium concolorvar.megalanthum.ResultsWe found that the sex expression ofLilium concolorvar.megalanthumwas variable in continuous years. Under limited resources,Lilium concolorvar.megalanthumincreases the biomass resources of the leaves and has a longer flowering period. Resource availability regulates the growth, reproduction and sex expression ofLilium concolorvar.megalanthum. Bulb size is the main factor affecting its growth, reproduction and sex expression after accumulating sufficient resources.DiscussionThis study confirms thatLilium concolorvar.megalanthumhas gender diphasy system. There is a strong trade-off between growth and reproduction under limited resources. Nutrient levels can regulate the reproduction and sex expression process ofLilium concolorvar.megalanthum. With the growth ofLilium concolorvar.megalanthumin consecutive years, the size dependence of bulbs may be the decisive factor in its sex expression.
Nivolumab and daratumumab combination regimens for the treatment of relapsed and refractory multiple myeloma: results of a randomized phase I/II clinical trial
Authors: Abdallah Al-Ola , Lesokhin Alexander , Wrobel Tomasz , Jamroziak Krzysztof , Dytfeld Dominik , Touzeau Cyrille , Suvannasankha Attaya , Leleu Xavier , Silbermann Rebecca , Khan Abdullah M. , Kumar Shaji , Gertz Morie , Laubach Jacob P. , Jou Ying-Ming , Bar Merav , Das Prianka , Wang Yu , Demers Korey , Stong Nicholas , Perumal Deepak , La Motte-Mohs Ross , MacLachlan Kylee , Dimopoulos Meletios-Athanasios 
Published: September 2023

PurposeThe phase I/II trial CheckMate 039 (NCT01592370) evaluated the safety, tolerability, and efficacy of nivolumab-daratumumab (ND) in patients with relapsed/refractory multiple myeloma (RRMM).MethodsPatients with RRMM were randomized to receive ND with or without pomalidomide-dexamethasone (Pd) in cohort A and ND or D monotherapy in cohort B. The primary endpoint was safety. Secondary endpoints included minimal residual disease (MRD) negativity status, overall response rate (ORR), duration of response, and progression-free survival (PFS).ResultsCohort A (n = 11) was terminated early due to safety concerns observed with immunomodulatory agents and checkpoint inhibitor combinations in other clinical trials. In the small number of patients treated in cohort A, no new safety concerns were observed but patients who received NDPd had numerically more grade 3/4 adverse events (AEs) and serious AEs compared with ND. Grade 3/4 AEs occurring in ≥ 1 patient in the ND group was anemia (3/6 patients); in the NDPd group, these were neutropenia (3/5 patients), upper respiratory tract infection (2/6 patients), and pneumonia (2/6 patients). In cohort B (n = 63), AE rates were similar between ND and D (any-grade: 87.8% vs 95.5%; grade 3/4: 53.7% vs 45.5%). Grade 3/4 AEs occurring in ≥ 1 patient in the ND group were neutropenia (19.5%), anemia (9.8%), thrombocytopenia (9.8%), and bronchitis (7.3%); in the D group these were anemia and pneumonia (both 9.1%). Immune-mediated AEs for ND were consistent with the known safety profile of nivolumab. In cohort A, all patients (5/5) receiving NDPd and 4/6 receiving ND achieved a response. In cohort B, the ORR with ND was numerically higher than D (22/41 [53.7%] vs 9/22 [40.9%]) and both groups had a median PFS of 6.6 months. ND also showed promising MRD negativity results (next-generation sequencing 10-5, 24.0%; next-generation flow 10-5, 22.2%).ConclusionNDPd demonstrated no new safety signals and encouraging efficacy despite its early termination. ND was well tolerated with a manageable toxicity and few AEs leading to discontinuation, and demonstrated a numerically higher ORR but equivalent PFS compared with D. Any clinical benefits to OS require a longer follow-up.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT01592370.
The high burden of erectile dysfunction among men living with HIV in northern Tanzania: a call for evidence-based interventions
Authors: Mbwambo Orgeness J. , Lyatuu Moses , Ngocho Geofrey , Abdallah Khadija , Godfrey Patricia , Ngowi Bartholomeo N. , Mremi Alex , Malindisa Evangelista , Amour Maryam , Ngocho James , Balandya Emmanuel , Kwesigabo Gideon , Manongi Rachel , Kidenya Benson R. , Mshana Stephen E. , Lyamuya Eligius F. , Sunguya Bruno F. , Bartlett John , Mmbaga Blandina Theophil , Mteta Alfred K. 
Published: September 2023

BackgroundThe extent of the burden of erectile dysfunction and its associated factors remains unclear. The aim of this study was to investigate the factors associated with ED and its prevalence among MLHIV in northern Tanzania.MethodsA hospital-based, multi-center, cross-sectional study was conducted on MLHIV aged 18 years and above in northern Tanzania.OutcomeThe risk factors for ED and the prevalence of such risk factors among MLHIV was assessed and evaluated through a multivariate logistic regression analysis adjusted for depression symptoms using the Patient Health Questionnaire-9 (PHQ9) scale; anxiety disorders using the Generalized Anxiety Disorder Assessment (GAD-7); ART adherence; viral load; initial regimen date; ART regimen; and sexual risk behaviors.ResultsData for 366 participants with a median age of 50 years (IQR 38–57 years) were available for analysis. Approximately three in four (74.6%) MLHIV had ED (of any severity), whereas 37.7% had mild ED. The majority (96.5%) of the participants had low testosterone, two in three (66.7%) had depressive symptoms, and close to half of the participants (48.4%) had anxiety. Age, lack of engagement in vigorous physical activity, depression, and self-reported good adherence to antiretroviral therapy (ART) were associated with ED in a multivariate logistic regression analysis (p=0.004, p =0.006, p=0.07, p=0.006, and p=0.004, respectively).ConclusionThere is a high prevalence of ED among MLHIV in northern Tanzania. Erectile dysfunction should be regarded as one of the comorbidities associated with HIV and should be routinely screened for among MLHIV in CTC clinics.
Risk factors associated with the prevalence of Listeria monocytogenes in manured soils on certified organic farms in four regions of the United States
Authors: Chandler-Khayd Carolyn , Di Francesco Juliette , Baron Jerome N. , Ramos Thais De Melo , Aminabadi Peiman , Jay-Russell Michele T. , Haghani Viktoria , Millner Patricia D. , Pagliari Paulo H. , Hutchinson Mark , Kenney Annette , Hashem Fawzy , Martínez-López Beatriz , Bihn Elizabeth A. , Clements Donna P. , Shade Jessica B. , Sciligo Amber R. , Pires Alda F. A. 
Published: September 2023

IntroductionBiological soil amendments, including raw or untreated manure, are currently used to improve soil fertility, especially in organic operations that prohibit use of synthetic fertilizers. However, addition of untreated manure may pose a risk of contamination of fresh produce by pathogens of public health significance, including Listeria monocytogenes. Organic growers follow United States Department of Agriculture (USDA) National Organic Program regulations for raw manure use, which stipulate that harvest should commence no earlier than 90- or 120-days post-application, depending on direct contact between the edible portion of the produce and the soil. To inform the protection that such time-intervals provide, this study explored the farm-level risk factors associated with L. monocytogenes prevalence in USDA-certified organic farm soils amended with untreated manures.MethodsA longitudinal, multi-regional study was conducted on 19 farms in four states (California, Minnesota, Maine, and Maryland) over two growing seasons (2017 and 2018). Untreated manure, soil, irrigation water, and produce samples were collected and cultured for L. monocytogenes. Mixed effect logistic regression was used to investigate risk factors associated with L. monocytogenes prevalence in soil.Results and DiscussionResults showed that multiple factors influenced the odds of a soil-positive sample, including temporal [year (OR = 0.19), sampling day (OR = 0.09–0.48)] and weather-related [temperature range (OR = 0.48)] variables, manure characteristics [season of application (OR = 0.04, summer), presence of L. monocytogenes (OR = 2.89) and other pathogens in manure (OR = 5.24)], farm management factors [water source (OR = 2.73, mixed), number of year-round staff (OR = 0.02)], and soil characteristics [concentration of generic Escherichia coli (OR = 1.45), moisture (OR = 0.46), organic matter (OR = 7.30), nitrate (OR = 3.07), potassium (OR = 0.09) and calcium (OR = 2.48)]. This study highlights the complexity of L. monocytogenes prevalence in soil and contributes science-based metrics that may be used when determining risk-mitigation strategies for pathogen contamination.
The Mediation Effect of Attitude on the Association Between Knowledge and Self-Management Behaviors in Chinese Patients With Diabetes
Authors: Zhang Yu , Zhang Beibei , Chen Cunchuan , Feng Xia , Song Suhang , Wang Haipeng 
Published: September 2023

Objective: This study aims to investigate the level of knowledge, attitude and self-management behaviors of diabetic patients, to explore the mediating role of attitude in the relationship between knowledge and self-management behaviors.Methods: 900 diabetes patients were randomly selected from the eastern, central and western regions of Shandong Province, China, and recovered 863 valid questionnaires. Path analysis was used to examine the mediating role of attitude in the relationship between knowledge and self-management behaviors in patients with diabetes.Results: The mean score (SD) of the diabetes self-management questionnaire (DSMQ) in this study was 35.01 (6.87). The direct effect value of knowledge level on self-management behaviors was 0.357, accounting for 62.09% of the total effect. The indirect effect value of knowledge on self-management behaviors through attitude was 0.218, accounting for 37.91%.Conclusion: Level of knowledge has a significant direct impact on self-management behaviors and an indirect impact on self-management behaviors through attitude. Therefore, it is necessary to strengthen health education on diabetes to improve awareness, ameliorate attitudes toward diabetes, and change self-management behaviors.
Timing of Early Salvage Therapy for Patients With Biochemical Relapse of Prostate Carcinoma
Authors: Argalácsová Soňa , Vočka Michal , Čapoun Otakar , Lambert Lukáš 
Published: September 2023

Between 25% and 33% of patients after radical prostatectomy experience a relapse of the disease. The risk of relapse increases in patients with risk factors up to 50%–80%. For a long time, adjuvant radiotherapy has been considered the standard of care. Four large prospective trials, that compared adjuvant and salvage radiotherapy in patients with biochemical relapse, showed the superiority of the adjuvant approach in biochemical and local relapse-free survival, but no consistent benefit in long-term endpoints (i.e., metastasis-free survival, overall survival, or carcinoma-specific survival) at the expense of increased urinary and bowel toxicity. Three large international studies comparing adjuvant and salvage radiotherapy paved the way toward early salvage radiotherapy. However, the optimal threshold of the PSA level (range of 0.2–0.5 ng/mL) for initiating early salvage radiotherapy remains unresolved and still poses a challenge in everyday clinical practice when balancing the need for early radiotherapy and the associated toxicity. Imprecise stratification of biochemical relaps patients according to the risk of clinical relapse drives efforts to find additional molecular biomarkers that would improve the timing of the salvage therapy.
Tingkat Konsumsi Lemak Hewani Dan Kejadian Hipertensi Di Desa Banjarangkan Kecamatan Banjarangkan Kabupaten Klungkung
Authors: Yanti Ni Luh Pt. Armini , Kusumajaya Anak Agung Ngurah , Padmiari Ida Ayu Eka 
Published: September 2023

Hipertensi atau penyakit tekanan darah tinggi adalah suatu gangguan pada pembuluh darah yang mengakibatkan suplai oksigen dan nutrisi, yang dibawa oleh darah, terhambat sampai ke jaringan tubuh yang membutuhkan.. Hipertensi erat kaitannya dengan pola makan yang salah. Hipertensi sering ditemukan di masyarakat dengan konsumsi lemak berlebih terutama lemak jenuh yang berasal dari hewani seperti daging-dagingan kususnya daging merah. Tujuan dari penelitian untuk mengetahui hubungan, tingkat konsumsi lemak hewani dengan kejadian hipertensi di Desa Banjarangkan, Kecamatan Banjarangkan, Kabupaten Klungkung. Jenis penelitian yang digunakan adalah observasional dengan rancangan cross sectional. Sampelpenelitian berusia 38 - 55 tahun sebanyak 63 orang yang diambil secara proporsional random sampling. Data yang dikumpulkan meliputi data, identitas sampel, tingkat konsumsi lemak hewani, dan tekanan darah. Data diolah dan dianalisis secara univariat dan bivariat. Hasil penelitian menemukan sebanyak42,9 % mengalami hipertensi. Yang didapatkan dari kejadian hipertensi yaitu dari 63 sampel yang telah diteliti, dari 36 sampel dengan status tekanan darah normal, sebagian besar tingkat konsumsi lemak hewani sampel kurang yaitu sebanyak 23 sampel (63,9%). Pada 27 sampel dengan status hipertensi seluruhnya (100,0%) tingkat konsumsi lemak hewani sampel tersebut tinggi. Dari uji koralasi product moment pearson yang dilakukan diperoleh nilai p=0,001 yang artinya pada taraf signifikan 5% ada hubungan tingkat konsumsi lemak hewani dengan kejadian hipertensi
What is the role of contact with animals in covid 19 pneumonia?
Authors: SARIHAN Aydın , ERAYBAR Suna , KORAN Serhat , CAN Çağdaş , ERDEMİR İsmail , RAHMAN Fatih , BULUT Mehtap 
Published: September 2023

Introduction: The novel corona virus (COVID-19) is considered to spread from person to person. There is no clear evidence that animals play a role in the spread of COVID-19.
Objectives: The subject of this study was the correlation between pet contact and COVID-19 pneumonia.
Patients and Methods: The participants were questioned by creating contact categories of indoor, garden, street and workplace as contact environments with pets.
Results: No statistically significant correlation was found when the COVID-19 patients who came into contact with pets in the home were compared whether they had COVID-19 pneumonia or not.
Discussion: Despite the fact that the probability of spread to humans from cats and dogs is low, COVID-19 can be spread to cats and dogs. In this study, it was detected that while those who came into contact with dogs were not different from those who were in contact with dogs, they had more lung involvement than those who had outdoor contact, which suggests that various mechanisms may play a role in virus spread.
Psöriatik Artrit Hastalarında C-Reaktif Protein/Albümin Oranının Klinik Önemi
Authors: USLU Sadettin , KOR İrem 
Published: September 2023

Giriş ve Amaç: C-reaktif protein (CRP)-albümin (ALB) oranı (CAO), yeni bir inflamatuar biyobelirteç olarak ortaya çıkmıştır. Çalışmanın amacı, psoriatik artrit (PsA) hastalarında CAO'nın klinik önemini değerlendirmektir.
Gereç ve Yöntem: 76 PsA hastası ve 48 sağlıklı kontrol grubu çalışmaya dahil edildi. Hastalar ve kontrollerden onam alındıktan sonra dosya kayıtları incelenerek, demografik bilgiler, başvuru anındaki klinik ve laboratuvar bulguları, nötrofil/lenfosit oranı (NLO), monosit/lenfosit oranı (MLO), trombosit/lenfosit oranı (PLO) ve C-reaktif protein/albümin (CAO) kaydedildi. PsA spesifik bir cilt tutulum ölçütü olan PASI skoru ve şiş-hassas eklem sayıları PsA'daki hastalık aktivitesinin ölçütleri olarak kullanıldı. CAO ile hastalık aktivite belirteçleri (Şiş-hassas eklem sayısı, PASI) ve geleneksel akut faz reaktanları [Eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP)] arasındaki korelasyona bakıldı.
Bulgular: PsA hastalarında CAO, sağlıklı gruptan önemli ölçüde yüksekti (p
Uma experiência com mundos encantados: a importância da literatura infantil nos anos iniciais do ensino fundamental
Authors: Almeida Amanda Roberta , Buchinger Carolina Arceles , Bandeira Larissa de Queiroz , Marques Natalia Anzolin , Mazzuco Neiva Gallina 
Published: September 2023

Este artigo originou-se das experiências vivenciadas na disciplina de Estágio Supervisionado, sob a forma de Prática de Ensino II direcionada aos Anos Iniciais do Ensino Fundamental. O objetivo central é relatar e refletir a respeito das ações de observação e de regência em classe. Para tanto, aplicou-se um projeto didático na área da Literatura Infantil, voltado a turmas de 1º e 2º anos do Ensino Fundamental de uma Escola Municipal localizada em Cascavel - PR, explorando-se a história O Caso do Bolinho, de Tatiana Belinky, e outras atividades a partir da narrativa. Durante as aulas ministradas, pudemos aprofundar os estudos acerca da história da Literatura Infantil, área do conhecimento relevante e que contribui para compreendermos nossas emoções ou a realidade em que estamos inseridos, além de nos tornar mais críticos, criativos e sensíveis (COELHO, 2000; ÁVILA; ALMEIDA, 2015). Na etapa da alfabetização, a Literatura Infantil é fundamental, principalmente pelo constante contato que a criança tem com o mundo da escrita, e isso deve ser aproveitado pelos professores, ao oportunizarem momentos que envolvem o lúdico, o imaginário, a criatividade e outros aspectos. Adquirimos, desse modo, muitas experiências e aprendizagens nesse período que, com certeza, agregarão em nossa futura atuação profissional.
IMPLEMENTASI PROGRAM TANGGUNG JAWAB SOSIAL DAN LINGKUNGAN DALAM MENDUKUNG PENGEMBANGAN USAHA MIKRO KECIL SUPPLY CHAIN DI PT PLN (PERSERO) PUSHARLIS
Authors: Fasya Ghitha Zahirah , Hendriyani Chandra , Damayanti Fenny 
Published: September 2023

<p align="justify">Business continuity is highly dependent on a harmonious relationship between the company and its supporting ecosystem such as employees, customers and the environment. To support this, the company must implement a Social and Environmental Responsibility (TJSL) program. The purpose of implementing the TJSL program is to contribute to the development of micro and small businesses or local communities. PT PLN (Persero) Pusharlis has a TJSL priority on the economic pillar through the development of the UMK Supply Chain which is in line with the 2030 Sustainable Development Goals (SDGs) goals of reducing poverty, unemployment, and improving people's welfare. This study uses a qualitative method with a descriptive approach to data collection techniques through interviews and literature studies. The object of research is CV Karya Mandiri Manufacture which is a fostered partner of PT PLN (Persero) Pusharlis which has succeeded in increasing production requests by 75 requests from the previous 50, resulting in an increase in employment of 22.2%. Thus it can be concluded that the TJSL program at PT PLN (Persero) Pusharlis was able to increase economic growth and absorb labor in the MSE Supply Chain. </p><p><strong>Key words:</strong> Social and Environmental Responsibility, TJSL, MSE, Supply Chain</p>