bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Immediate Effect of Orthopaedic Manual Therapy on Cervical Paravertebral Soft Tissue: A Study Using Soft Tissue Tension Cloud Chart Technology
Authors: Wang Xu , Jin Zikai , Feng Tianxiao , Fang Shengjie , Sun Chuanrui , Qin Xiaokuan , Sun Kai , Liang Long , Liu Guangwei , Zhu Liguo , Wei Xu 
Published: July 2023

Abstract
Background:
To evaluate the reliability the Soft Tissue Tension Cloud Chart(STTCC) technology, an original method combining multi-point Cervical Paravertebral Soft Tissue Test(CPSTT) with MATLAB software, and preliminary analyze immediate effect of Orthopaedic Manual Therapy(OMT) on Cervical Paravertebral Soft Tissue.
Methods:
30 patients with Cervical Spondylotic Radiculopathy(CSR) are included in this study to analyze the difference between before and after the treatment of Cervical Rotation-Traction Manipulation(CRTM), the representative of OMT in Traditional Chinese Medicine by STTCC technology.
Results:
The STTCC results show that the CPSTT after CRTM in CSR patients is significantly lower than before CRTM, with a statistically significant difference(P<0.001). Meanwhile, the CPSTT of the ill side(with radicular pain or numbness) is higher than that of the healthy side(without symptoms) from the fifth to seventh cervical segment before CRTM(P<0.001), while this difference disappears after CRTM(P=0.231).
Conclusions:
STTCC technology is a reliable method to analyze the immediate effect of OMT. CSR patients have the characteristics of an uneven distribution of CPSTT; CRTM not only has the effect of reducing the cervical soft tissue tension of CSR patients but also can balance their uneven distribution between the ill side and the healthy side.
Trial registration:
This study was approved by the Chinese Clinical Trials Registry(Website: .https://www.chictr.org.cn.)on 20/04/2021 and the Registration Number is ChiCTR2100045648.
Temporal coherence in particulate matters in East Asian outflow regions: fingerprints of ENSO, Asian dust and COVID-19
Authors: Lin Chuan-Yao , Kueh Mien-Tze , Chien Yi-Yun 
Published: July 2023

Abstract
Understanding temporal coherence in particulate matter (PM) pollution across East Asian outflow regions is crucial for collaborative efforts in addressing air pollution challenges. In this study, we analyze daily PM exceedance patterns using ground-based measurements over the past two decades, focusing on the influence of El Niño-Southern Oscillation (ENSO) and Asian dust activity. ENSO-related coherent PM exceedance shows lower occurrence during El Niño compared to La Niña in spring, due to weakened continental outflows and increased precipitation. Temporal distribution of dust-related coherent PM exceedance closely mirrors springtime dust activity in source regions, indicating significant dust emission impact on outflow regions. Furthermore, COVID-19 restrictions likely contributed to decreased PM levels in the spring of 2020. Our findings have implications for climate variability and the assessment of multi-decade model simulations.
Different concentrations of carbon quantum dots on cadmium tolerance and accumulation in ryegrass
Authors: duan shengnan , dong yuanjie 
Published: July 2023

Abstract
Purpose Heavy metal pollution in the environment may affect plant growth. Exploring remediation agents that alleviate cadmium toxicity in plants is the research hot spots in the field of cadmium pollution remediation agent around the world.
Methods The ryegrass culture variety "Dongmu 70" was used as the test material, based on Hoagland nutrient solution, the experiment set normal nutrient solution（CK）, normal nutrient solution+100 mg·L-1CDs（CDs）, 100 mol·L-1 Cd stress nutrient solution（Cd）, Cd+50 mg·L-1CDs（T1）, Cd +100 mg·L-1 CDs（T2）, Cd +150 mg·L-1 CDs（T3）. There were 6 treatments. To study the effects of CDs on the physiological characteristics of ryegrass treated for 18 days under cadmium stress.
Results The results showed that cadmium stress severely inhibited the growth of ryegrass. The application of CDs could effectively alleviate the cadmium stress of ryegrass. Compared with the Cd treatment, the plant height, fresh weight, dry weight and root activity of T2 were increased by 54.89%, 117.3%, 116.67% and 58% respectively, the total chlorophyll content of T2 was increased by 68.1%, the activities of SOD, POD and CAT increased significantly, Cd accumulation in leaves and roots of T2 was decreased by 22.92% and 34.74% respectively, CDs could effectively adsorb Cd2+ and reduce its entry into ryegrass. Under the experimental conditions, the mitigation effect of CDs on Cd stress increased with the increase of CDs concentration. The repair effect of 100 mg·L-1 CDs on cadmium toxicity caused by 100 mol·L-1 Cd2+ is the best. The repair effect did not increase significantly with the increase of concentration, and even there will be inhibitory effect.
Conclusion Application of CDS could promote the growth of ryegrass under cadmium stress, improve the content of photosynthetic pigment and the activity of antioxidant enzymes in ryegrass, remove excess reactive oxygen species, and inhibit the absorption of cadmium by ryegrass，effectively alleviate the cadmium stress of ryegrass. This study can provide a basis for the application of CDs as a new cadmium pollution remediation agent in soil remediation.
Hospital-Induced Immobility – A Backstage Story of Lack of Chairs, Time, and Assistance
Authors: Piper Katrine Storm , Oxfeldt Martin , Pedersen Mette Merete , Christensen Jan 
Published: July 2023

Abstract

Background
Inactivity and bedrest during hospitalisation have numerous adverse consequences, and it is especially important that older patients are mobile during hospitalisation. This study aimed to identify whether the introduction of formal education of clinical staff and a Mobilisation Initiative (MI) could increase mobilisation of patients in a geriatric and a medical ward. Furthermore, to explore patients’ and health care staffs’ view on facilitators and barriers for mobilisation during hospitalisation.
Methods
The study was a pragmatic clinical study. Both qualitative and quantitative methods were used. The patients’ level of mobilisation was obtained through short interview-based surveys and observations. Focus group interviews and formal education of clinical staff was initiated to increase awareness of mobilisation along with the implementation of a MI.
Results
596 patient surveys were included. Of all patients, 50% in the geriatric ward and 70% in the medical ward were able to independently mobilise. The highest percentage of patients sitting in a chair for breakfast and lunch in the geriatric ward was 57% and 65%, and in the medical ward 23% and 26%, respectively. A facilitator for mobilisation was interdisciplinary collaboration, and barriers were lack of chairs and time, and the patients’ lack of help transferring.
Conclusions
This study adds new knowledge regarding the lack of in-hospital mobilisation in geriatric and medical departments. Mealtimes are obvious mobilisation opportunities, but most patients consume their meals in bed. A potential for a MI is present, however, it must be interdisciplinarily and organisationally anchored for further investigation of effectiveness.
Trial registration
Retrospectively registered.
Energy Consumption, Environmental Quality and Health Nexus in West African Countries: Implications for Sustainable Development
Authors: Aderinto Esther 
Published: July 2023

Abstract

Energy remains indispensable in production and consumption activities and is therefore the driving force of economic growth and improved living standard. Despite the fact that Africa is rich in renewable energy, the continent’s energy mix is largely dominated by the fossil fuels. This could have deteriorating effects on the environment and subsequently on the health of people across the continent. The sustainable development goals are geared towards ensuring a sustainable future for all, with good health, well-being and sustainable environment as part of the principal targets. However, most developing countries including West African countries have been experiencing declining health patterns following the lack of attention on health-related factors like energy and environment. This study therefore intends to examine the nexus among energy consumption, environmental quality and health in West African countries while employing data from 2000 to 2019. The study disintegrates energy consumption into renewable and non-renewable energy. Pooled Mean Group Autoregressive Distributed Lag (PMG/ARDL) model was employed for the study. Short run estimates reveal a negative influence of non-renewable energy on life expectancy in West African countries. Similarly, non-renewable energy exerts a significant and negative influence on child mortality. Non-renewable energy also reduces health expenditure. Renewable energy was observed to increase life expectancy and reduce child mortality. The study concludes that a substantial amount of renewable energy be incorporated into the energy basket of West African countries to improve health conditions.
The Efficacy and Mechanism of Kaempferol in Preventing perioperative neurocognitive disorders in t he Elderly: Based on Network Pharmacology and Experimental Verification
Authors: Huang Enhao , LI Huadao , Han Hanghang , Liang Yubing , Huang Zijin , Qin Ke , Du Xueke 
Published: July 2023

Abstract
Objective
This research, founded on network pharmacology, molecular docking, and experimental validation, seeks to elucidate the probable therapeutic effects of Kaempferol (Kae) on perioperative neurocognitive disorders (PND), along with its operational mechanism.
Methods
Key target points for the potential preventive effects of Kae on PND were discerned through the Geo database and network pharmacology techniques. An animal model was established for PND through laparotomy. The model and therapeutic outcomes were verified using the Morris water maze (MWM) and open field tests, subsequently, mechanisms of hub target regulation were confirmed through methods such as WB, q-PCR, immunofluorescence, flow cytometry, JC-1 staining for mitochondrial membrane potential (ΔΨm) assessment, and Calcein-AM staining. In vivo and in vitro experimental models were utilized to study the impact of Kae on microglial cell activation and inflammation, as well as Kae’s rescuing effect on neuronal apoptosis, thereby exploring its neuroprotective action mechanism.
Results
Network pharmacology analysis revealed that Kae could potentially exert its therapeutic effect by regulating key targets such as p-AKT1, p-JUN, PPARG, and CASPASE − 3. These targets primarily function within inflammation and immune modulation related pathways such as the AGE-RAGE signaling pathway, TNF-α signaling pathway, and apoptosis. In vivo and in vitro model experiments demonstrated that Kae significantly influenced the activation and inflammatory response of microglial cells, indicating possible neuroprotective effects. Additionally, Kae was able to mitigate the apoptosis of primary neurons induced by LPS, a phenomenon that Kae rescues in a concentration-dependent manner.
Conclusion
By regulating key targets such as p-AKT1, p-JUN, PPARG, and CASPASE-3, Kae might play a role in the prevention and treatment of PND, demonstrating neuroprotective and cognitive function improvement effects.
Allium covered metal stent for treatment of malignant ureteral obstruction
Authors: zhang jiamo , LI Dexia , ZHANG Xuan , LUO Huaming , CHEN Jiangchuan , LI Changlong , CHEN Xin 
Published: July 2023

Abstract
Objective. To evaluate the safety and efficacy of the Allium covered metallic stent for the treatment of malignant ureteral obstruction.
Patients and Methods. Clinical data of 29 patients who underwent endoscopic insertion of an Allium ureteral stent between October 2019 and August 2021 at Yongchuan Hospital, affiliated with Chongqing Medical University, were analyzed retrospectively. At 1, 3, 6 and 12 months after insertion, serum creatinine was measured, the width of the renal pelvis was rechecked under ultrasound guidance, and the position and shape of the stent were checked by abdominal X-ray. Data on long-term stent patency, incidence of complications, changes in renal function and hydronephrosis grade were collected and analyzed. Ureteral stent symptom questionnaire (USSQ) was administered preoperatively and after 6 months in 22 patients with previous stent history.
Results. Allium covered metal stents (n=33) were implanted successfully in 29 patients who were followed for 3 to 22 months, with 32/33 stents remaining patent. Serum creatinine levels decreased in 17 patients and hydronephrosis in 24 patients. Clavien-Dindo grade I complications were observed in 6 patients, Clavien-Dindo II in 1 patient, whereas stent displacement and stent encrustation occurred in one patient each (Clavien-Dindo III-IV). USSQ scores had significantly improved 6 months after stent insertion (p<0.001).
Conclusion Allium ureteral stents are a safe and effective treatment option for malignant ureteral obstruction, with good long-term patency, helping to preserve renal function and improve quality of life.
Porous Nanocomposites with Enhanced Intrinsic Piezoresistive Sensitivity for a Highly Integrated Multimodal Tactile Sensor
Authors: Peng Zhengchun , Zhang Jianpeng , Wei Song , Liu CaiChao , Shang Chao , He Zhaoqiang , Duan Yu 
Published: July 2023

Abstract
In this work, we propose a new and low cost elastomeric nanocomposite, i.e., porous fluororubber-thermoplastic urethanes nanocomposites (PFTNs), and demonstrate the highest intrinsic piezoresistive sensitivity to pressure among the known porous nanocomposites. Our experiments indicate that the PFTN's intrinsic sensitivity to pressure (within 10kPa) increases up to 900% compared to the porous thermoplastic urethanes nanocomposite (PTN) and up to 275% compared to the porous fluororubber nanocomposite (PFN), respectively. For pressures exceeding 10 kPa, the pressure-resistance relationship follows a logarithmic function, and the sensitivity of PFTN to the logarithm of pressure is observed to be 221% and 125% higher than that of PTN and PFN, respectively. Along with the change of contact resistance at the micro-porous interface between PFTN and electrode, the excellent intrinsic sensitivity of thick PFTN films makes it ideal to imitate multiple skin functions, such as touch detection, pressure perception and traction sensation, in a single sensing unit. The sensitivity to touch of the e-skin reaches approximately 150 Pa, and it exhibits a linear fit degree of over 97% for monitoring the applied pressure and shear force. We also demonstrate an array-based e-skin capable of accurately recognizing pinch, spread, and tweak motions.
Finite Element Analysis and Structure Optimization of a Gantry-Type High-Precision Machine Tool
Authors: Chan Tzu-Chi , Ullah Aman , Roy Bedanta , Chang Shinn-Liang 
Published: July 2023

Abstract
The high-precision machine tool's dynamic, static, and rigid nature directly affects the machining efficiency and surface quality. Static and dynamic analyses are essential for the design and improvement of precision machine tools to ensure good tool performance under difficult and demanding machining conditions. In this study, the performance of a high-precision machine tool was analyzed using its virtual model created using SOLIDWORKS. Static and model analysis using ANSYS Workbench software was conducted to establish the tool's static deformation and static stiffness. Furthermore, the static and dynamic characteristics of the tool were explored using a ﬁnite element modeling approach to study their performance. In particular, the structure, static force, modal, frequency spectrum, and topology optimization of machine tools were primarily analyzed. Using model analysis, we found the first four different frequencies (22.5, 28.9, 40.6, and 47.4 Hz) and vibration type, which suggested of a weak link. Further static structural analysis revealed that the deformation of the spindle was 67.26 μm. An experimental static rigidity analysis was performed, and the experimental deformation values of the tool and spindle were obtained. The static and dynamic characteristics, as well as the accuracy and efficiency of the finite element model, were verified by comparing the data with the Finite Element Analysis (FEA) results. Subsequently, we modified the settings and analysis model to ensure that the analysis results were consistent with the experimental findings. The error between the two results was within 1.56%. For an applied load of 5000 N on the spindle nose, the tool nose transient response was 0.5 s based on transient analysis. Under the condition that the structural deformation is as constant as possible, the lightweight structure may achieve the minimum weight and enhance the natural frequency; thus, the ideal structure will be obtained, and finite element analysis will then be performed. The optimal conditions for topology optimization include a lightweight structure, reduced structural deformation, and increased natural frequency of the structure. The developed method improves structural optimization, increases the ability of the product to be manufactured, and offers designers a variety of price-effective options.
Multidomain Interventions for Non-pharmacological Enhancement (MINE) Program in Chinese Older Adults with Mild Cognitive Impairment: A Multicenter Randomized Controlled Trial Protocol
Authors: Wu xiaochu , Zhang Tianyao , Tu Yanhao , Deng Xueling , A Sigen , Li Yuxiao , Jing Xiaofan , Wei Lixuan , Huang Ning , Cheng Ying , Deng Linghui , Jia Shuli , li Jun , Jiang Ning , Dong Birong 
Published: July 2023

Abstract
Background: Dementia is characterized by progressive neurodegeneration and therefore early intervention could have the best chance of preserving brain health. There are significant differences in health awareness, living customs, and daily behaviors among Chinese older adults compared to Europeans and Americans. Because the synergistic benefits of multidomain non-pharmacological interventions are consistent with the multifactorial pathogenicity of MCI, such interventions are more appealing, easier to adhere to, and more relevant to daily life than single-mode interventions. This study aims to validate multidomain intervention strategies for MCI patients based on Chinese population characteristics, establish a biological sample and image database to investigate the pathogenesis and pathways of cognitive impairment.
Methods: Our study was designed as a national multicenter, community-based randomized controlled trial (RCT). Twelve medical institutions in ten Chinese cities will participate in our study from 2020 to 2024, and 1080 community residents aged 50 and above will be enrolled as participants. Each sub-center will be responsible for 90 participants (30 people per community) across three communities (non-contact control group, health education group, and multidomain intervention group). The community will be the basic unit of the present study, and all participants in each community will receive the same intervention/control measure. Three working groups are set up in each sub-center to manage the three communities independently to minimize interference at the implementation level between the groups. This study will use exercise, nutrition, sleep, mindfulness meditation and other methods to conduct comprehensive multi-domain intervention in participants. All data generated by the research will be analyzed and processed by statistical software (such as SPSS, R, etc.), and part of the research data will be displayed in the form of graphs and tables.
Discussion: In order to achieve a high-quality community intervention study, it is crucial to have a well-designed experimental protocol that follows rigorous scientific methodology. In addition, effective management of quality control measures and monitoring compliance throughout the study process are essential components. This study provides a detailed discussion of stakeholder compliance, research quality control, potential harm and mitigation, auditing, and future plans in order to better address research issues.
Trial registration: ChiCTR2000035012
Immune thrombocytopenia secondary to primary cytomegalovirus infection after renal transplantation treated with a thrombopoietin receptor agonist: a case report
Authors: Takehara Tomohiro , Nishida Hayato , Ichikawa Kazunobu , Hosokawa Yuka , Nawano Takaaki , Takai Satoshi , Fukuhara Hiroki , Himuro Masahito , Tsuchiya Norihiko , Watanabe Masafumi 
Published: July 2023

Abstract
Background: Immune thrombocytopenia (ITP) is an acquired disorder characterised by low platelet counts due to immune-mediated destruction and impaired platelet production. We report a rare case of primary cytomegalovirus (CMV) infection followed by thrombocytopenia after renal transplantation (RT).
Case presentation: A 24-year-old male patient with end-stage kidney disease secondary to hereditary focal segmental glomerulosclerosis was treated with peritoneal dialysis and received ABO-compatible living-related RT from his aunt. Nine months after RT, the patient was diagnosed with primary CMV infection. After treatment initiation for primary CMV infection, the patient developed isolated thrombocytopenia. Excluding other diseases or drugs that might cause thrombocytopenia, the patient was finally diagnosed with ITP, administered prednisolone (PSL),and started on Helicobacter pylori (H. pylori) eradication therapy. Tapering the PSL dose was difficult. However, thrombopoietin receptor agonists (TPO-RAs) were effective.
Conclusions: In this case, the patient was diagnosed with ITP, and other causes of thrombocytopenia were successfully ruled out, despite the many causes of thrombocytopenia after RT. We showed that RT recipients can develop ITP after CMV infection and, in such cases, TPO-RAs may be an attractive option as a second-line therapy.
Differential diagnosis of breast mucinous carcinoma with oval shape from fibroadenoma based on ultrasonographic features
Authors: Wang Hongli , Hu Yue , Tan Cui , Gu Ran , Li Yudong , Jin Liang , Jiang Xiaofang , Mei Jingsi , Liu Qiang , Gong Chang 
Published: July 2023

Abstract
Background Approximately 50% of breast mucinous carcinomas (MCs) are oval and have the possibility of being misdiagnosed as fibroadenoma (FA). We aimed to identify the key features that can help differentiate breast MC with oval shape from fibroadenoma (FA) on ultrasonography (US).
Methods Seventy-six MCs in 71 consecutive patients and 50 FAs with oval shape in 50 consecutive patients were included in our study. All lesions had pathological diagnoses. According to the Breast Imaging Reporting and Data System (BI-RADS), first, the ultrasonographic features of the MCs and FAs were recorded and a final category was assessed. Then, the differences of ultrasonographic characteristics between category 4A (low-risk group) and category 4B-5 (medium-high risk group) of MCs were identified. Finally, other ultrasonographic features of MC and FA both with oval shape were compared to determine the key factors for differential diagnosis. The Mann-Whitney test, the χ2 test or Fisher’s exact test was used in our study.
Results MCs with oval shape (81.2%) and circumscribed margin (25%) on US were more common assessed in the low-risk group (BI-RADS 4A) than in the medium-high risk group (BI-RADS 4B-5) (20%，p<0.001 and 0% p=0.001, respectively). Compared with FA, patients with MC were older, and with masses being more likely to appear non-hypoechoic, not circumscribed margin, and posterior echo enhancement on US (p<0.001, p<0.001, p=0.003, respectively).
Conclusion: The oval shape was the main reason for the underestimation of MCs. On US, an oval mass found in the breast of an old woman with non-hypoechoic echo, not circumscribed margin, and posterior echo enhancement was associated with an increased risk of MC, and active biopsy should be recommended.