bluuebunny/crossref_metadata_2025_split huggingface dataset:
Line profile of nuclear de-excitation gamma-ray emission from very hot plasma
Authors: Yoneda Hiroki , Aharonian Felix , Coppi Paolo , Siegert Thomas , Takahashi Tadayuki 
Published: September 2023

ABSTRACT
De-excitation gamma-ray lines, produced by nuclei colliding with protons, provide information about astrophysical environments where particles have kinetic energies of 10–100 MeV per nucleon. In general, such environments can be categorized into two types: the interaction between non-thermal MeV cosmic rays and ambient gas, and the other is thermal plasma with a temperature above a few MeV. In this paper, we focus on the latter type and investigate the production of de-excitation gamma-ray lines in very hot thermal plasma, especially the dependence of the line profile on the plasma temperature. We have calculated the line profile of prompt gamma rays from 12C and 16O and found that when nuclei have a higher temperature than protons, gamma-ray line profiles can have a complex shape unique to each nucleus species. This is caused by anisotropic gamma-ray emission in the nucleus rest frame. We propose that the spectroscopy of nuclear de-excitation gamma-ray lines may enable to probe energy distribution in very hot astrophysical plasmas. This diagnostics can be a new and powerful technique to investigate the physical state of a two-temperature accretion flows onto a black hole, especially the energy distributions of the protons and nuclei, which are difficult to access for any other diagnostics.
Exploring the Bidirectional Causal Pathways Between Smoking Behaviors and Headache: A Mendelian Randomization Study
Authors: Lloyd Katherine , Harrison Sean , Sallis Hannah M , Davey Smith George , Munafò Marcus R , Wootton Robyn E 
Published: September 2023

Abstract

Introduction
Although observational data suggest a relationship between headache and smoking, there remain questions about causality. Smoking may increase headache risk, individuals may smoke to alleviate headaches, or smoking and headache may share common risk factors. Mendelian randomization (MR) is a method that uses genetic variants as instruments for making causal inferences about an exposure and an outcome.

Aims and Methods
First, we conducted logistic regression of observational data in UK Biobank assessing the association between smoking behaviors (smoking status, cigarettes per day amongst daily smokers, and lifetime smoking score) on the risk of self-reported headache (in the last month and for more than 3 months). Second, we used genetic instruments for smoking behaviors and headache (identified in independent genome-wide association studies [GWAS]) to perform bidirectional MR analysis.

Results
Observationally, there is a weak association between smoking behavior and experiencing headache, with increased cigarettes per day associated with increased headache risk. In the MR analysis, genetic liability to smoking initiation and lifetime smoking increased odds of headache in the last month but not odds of headaches lasting more than 3 months. In the opposite direction, there was weak evidence for higher genetic liability to headaches decreasing the chance of quitting.

Conclusions
There was weak evidence for a partially bidirectional causal relationship between smoking behaviors and headache in the last month. Given this relationship is distinct from smoking heaviness, it suggests headache and smoking may share common risk factors such as personality traits.

Implications
Using MR, this study addresses the uncertainty regarding the observed relationship between headache and smoking. There was evidence for weak causal effects of smoking initiation and lifetime smoking (but not smoking heaviness) on likelihood of experiencing headache in the last month, but not over a prolonged period of more than 3 months. Those with higher genetic liability to headaches were also less likely to successfully stop smoking. This partially bidirectional causal relationship distinct from smoking heaviness suggests that observed associations are unlikely due to biological effects of tobacco smoke exposure and may be explained by shared personality traits.
An easy-to-use high-throughput selection system for the discovery of recombinant protein binders from alternative scaffold libraries
Authors: Möller Marit , Jönsson Malin , Lundqvist Magnus , Hedin Blenda , Larsson Louise , Larsson Emma , Rockberg Johan , Uhlén Mathias , Lindbo Sarah , Tegel Hanna , Hober Sophia 
Published: September 2023

Abstract
Selection by phage display is a popular and widely used technique for the discovery of recombinant protein binders from large protein libraries for therapeutic use. The protein library is displayed on the surface of bacteriophages which are amplified using bacteria, preferably Escherichia coli, to enrich binders in several selection rounds. Traditionally, the so-called panning procedure during which the phages are incubated with the target protein, washed and eluted is done manually, limiting the throughput. High-throughput systems with automated panning already in use often require high-priced equipment. Moreover, the bottleneck of the selection process is usually the screening and characterization. Therefore, having a high-throughput panning procedure without a scaled screening platform does not necessarily increase the discovery rate. Here, we present an easy-to-use high-throughput selection system with automated panning using cost-efficient equipment integrated into a workflow with high-throughput sequencing and a tailored screening step using biolayer-interferometry. The workflow has been developed for selections using two recombinant libraries, ADAPT (Albumin-binding domain-derived affinity proteins) and CaRA (Calcium-regulated affinity) and has been evaluated for three new targets. The newly established semi-automated system drastically reduced the hands-on time and increased robustness while the selection outcome, when compared to manual handling, was very similar in deep sequencing analysis and generated binders in the nanomolar affinity range. The developed selection system has shown to be highly versatile and has the potential to be applied to other binding domains for the discovery of new protein binders.
Similarity in functional connectome architecture predicts teenage grit
Authors: Park Sujin , Park Daeun , Kim M Justin 
Published: September 2023

Abstract
Grit is a personality trait that encapsulates the tendency to persevere and maintain consistent interest for long-term goals. While prior studies found that grit predicts positive behavioral outcomes, there is a paucity of work providing explanatory evidence from a neurodevelopmental perspective. Based on previous research suggesting the utility of the functional connectome (FC) as a developmental measure, we tested the idea that individual differences in grit might be, in part, rooted in brain development in adolescence and emerging adulthood (N = 64, 11–19 years of age). Our analysis showed that grit was associated with connectome stability across conditions and connectome similarity across individuals. Notably, inter-subject representational similarity analysis revealed that teenagers who were grittier shared similar FC architecture with each other, more so than those with lower grit. Our findings suggest that individuals with high levels of grit are more likely to exhibit a converging pattern of whole-brain functional connectivity, which may underpin subsequent beneficial behavioral outcomes.
Mothers exhibit higher neural activity in gaining rewards for their children than for themselves
Authors: Zhang Yan , Rong Yachao , Wei Ping 
Published: September 2023

Abstract
Are people willing to exert greater effort to obtain rewards for their children than they are for themselves? Although previous studies have demonstrated that social distance influences neural responses to altruistic reward processing, the distinction between winning rewards for oneself and winning them for one’s child is unclear. In the present study, a group of 31 mothers performed a monetary incentive delay task in which cue-induced reward anticipations of winning a reward for themselves, their children and donation to a charity program were manipulated trial-wise, followed by performance-contingent feedback. Behaviorally, the anticipation of winning a reward for their children accelerated participants’ responses. Importantly, the electroencephalogram results revealed that across the reward anticipation and consumption phases, the child condition elicited comparable or higher brain responses of participants than the self condition did. The source localization results showed that participants’ reward anticipations for their children were associated with more activation in the social brain regions, compared to winning a reward for themselves or a charity donation. Overall, these findings advance our understanding of the neural mechanisms of altruistic reward processing and suggest that the priority of winning a reward for one’s child may transcend the limits of the self-advantage effect in reward processing.
A Culture of White Violence: The Enduring Impact of Slavery on Contemporary Interracial Killings
Authors: Reid Jonathan C 
Published: September 2023

AbstractWhile the literature has documented various factors influencing the geographic distribution of interracial homicide, little is known about the role of historical antecedents. This article deepens our understanding of interracial homicide by investigating the relationship between slavery and contemporary interracial killings in the American South. The study draws on historical accounts of race-making and Black dehumanization to argue that slavery provided a fertile backdrop for the emergence of a culture of White interracial violence. Slavery’s legacy in this regard is expected to influence contemporary rates of White interracial homicide but not impact other racial homicide outcomes. Findings from county-level negative binomial regression models support these predictions, revealing a significant association between the historical legacy of slavery and higher rates of White-on-Black Southern killings. Conversely, slavery does not influence other race-specific homicide patterns, including Black-on-White, White-on-White, and Black-on-Black homicide.
NANN Membership Recommendations
Authors: Vance Ashlee J. , Farmer Meredith L. , D'Agata Amy , Moore Tiffany , Esser Media , Fortney Christine A. 
Published: September 2023

Background:
Neonatal care has advanced significantly in recent years, yet racial health inequities persist in the neonatal intensive care unit (NICU), with infants from racial and ethnic minority groups less likely to receive recommended treatment. Healthcare providers acknowledge that there are steps that can be taken to increase knowledge and awareness regarding health inequities.

Purpose:
To better understand current health equity–related initiatives in the neonatal community and solicit feedback from National Association of Neonatal Nurses (NANN) membership about advancing racial equity within the organization.

Methods:
A cross-sectional survey was conducted in January 2021. The anonymous, onetime survey was distributed to active NANN members via SurveyMonkey and included questions related to racial equity initiatives, recommendations, and demographics. Data analysis was conducted using an exploratory approach using descriptive statistics, and thematic analysis was used to summarize responses to open-ended questions.

Results:
There were 325 members who completed the full survey, of whom were White (83%), female (96%), staff nurses (42%), and those with more than 16 years of experience (69%), and most (69%) were familiar with NANN's racial equity position statement. Recommendations were summarized into the following themes: (1) research, (2) education, (3) workforce diversity, (4) communication, (5) scholarships, (6) resources, and (7) community outreach.

Implications for Practice and Research:
NANN members offered clear and actionable recommendations to advance health equity within the neonatal community and organization, which included offering more diversity, inclusion, and equity education at the annual conferences, in ANC articles, and newsletters, and the creation of scholarships or reduced membership fees to encourage diverse enrollment in the organization.
Abduction Bracing Following Anterior Open Reduction for Developmental Dysplasia of the Hip Does Not Improve Residual Dysplasia or Reduce Secondary Surgery
Authors: Kak Arnav , Morris William Z. , Mayfield Laura M. , Jo Chan-Hee , Kim Harry K.W. 
Published: September 2023

Background:
Abduction bracing is commonly used following open reduction and spica casting of developmental dysplasia of the hip. However, there is little evidence to support or refute this practice that carries associated cost and burden for families. The purpose of this study was to determine the efficacy of abduction bracing after open reduction in improving the acetabular dysplasia and reducing the rate of secondary surgery for residual dysplasia.

Methods:
This is a retrospective study of patients treated with open reduction at a single tertiary referral center. Demographic data, severity of dislocation [International Hip Dysplasia Institute (IHDI) class], age at reduction, and casting duration were obtained. Patients were prescribed no bracing, part-time (≤18 h/d), or full-time (≥20 h/d) brace wear based on surgeon preference. Acetabular index (AI) measurements were obtained at cast removal and at 2- and 4-year follow-up.

Results:
A total of 146 hips underwent open reduction with 61% (89/146) of hips treated with abduction bracing. There was no difference between braced and nonbraced cohorts with regards to sex, age at time of reduction, dislocation severity, cast duration, immediate postcasting AI, or incidence of medial open reduction. There was no difference in hips treated with or without brace following open reduction with regards to AI at 2 years postreduction (31.8±6.7 vs. 30.4±6.1 degrees, P=0.27) or at 4 years postreduction (24.9±6.5 vs. 24.7±6.5 degrees, P=0.97). However, further analysis showed lower mean AI at 2-year follow-up for braced versus nonbraced patients following medial open reduction (30.0±5.7 vs. 34.5±7.0 degrees, P=0.02). This difference was no longer present at 4-year follow-up (26.6±6.8 vs. 24.2±6.6 degrees, P=0.44). However, 4/19 (21%) nonbraced hips underwent secondary surgery for residual dysplasia and were consequently excluded from the AI measurement at 4 years postreduction (compared with 4/39 [10%] braced hips within the same time period). There was no difference in the rate of secondary surgery between braced and nonbraced hips (30% vs. 33%, respectively, P=0.70). Multivariate analysis demonstrated that neither IHDI classification, bracing, nor age at reduction predicted residual dysplasia.

Conclusions:
Abduction bracing following anterior open reduction for developmental dysplasia of the hip is not associated with decreased residual dysplasia at 2/4 years postreduction or with decreased secondary surgery. These results suggest that abduction bracing following anterior open reduction may not provide clinical benefit. However, abduction bracing may be beneficial following medial open reduction. A prospective study is necessary to provide more definitive recommendations.

Level of Evidence:
Level III—therapeutic study.
Quantifying Typical Progression of Adolescent Idiopathic Scoliosis
Authors: Labrom Fraser R. , Izatt Maree T. , Askin Geoffrey N. , Labrom Robert D. , Claus Andrew P. , Little J. Paige 
Published: September 2023

Study Design.
A prospective cohort study.

Objective.
Detail typical three-dimensional segmental deformities and their rates of change that occur within developing adolescent idiopathic scoliosis (AIS) spines over multiple timepoints.

Summary of Background Data.
AIS is a potentially progressive deforming condition that occurs in three dimensions of the scoliotic spine during periods of growth. However, there remains a gap for multiple timepoint segmental deformity analysis in AIS cohorts during development.

Materials and Methods.
Thirty-six female patients with Lenke 1 AIS curves underwent two to six sequential magnetic resonance images. Scans were reformatted to produce images in orthogonal dimensions. Wedging angles and rotatory values were measured for segmental elements within the major curve. Two-tailed, paired t tests compared morphologic differences between sequential scans. Rates of change were calculated for variables given the actual time between successive scans. Pearson correlation coefficients were determined for multidimensional deformity measurements.

Results.
Vertebral bodies were typically coronally convexly wedged, locally lordotic, convexly axially rotated, and demonstrated evidence of local mechanical torsion. Between the first and final scans, apical measures of coronal wedging and axial rotation were all greater in both vertebral and intervertebral disk morphology than nonapical regions (all reaching differences where P<0.05). No measures of sagittal deformity demonstrated a statistically significant change between scans. Cross-planar correlations were predominantly apparent between coronal and axial planes, with sagittal plane parameters rarely correlating across dimensions. Rates of segmental deformity changes between earlier scans were characterized by coronal plane convex wedging and convexly directed axial rotation. The major locally lordotic deformity changes that did occur in the sagittal plane were static between scans.

Conclusions.
This novel investigation documented a three-dimensional characterization of segmental elements of the growing AIS spine and reported these changes across multiple timepoints. Segmental elements are typically deformed from initial presentation, and subsequent changes occur in separate orthogonal planes at unique times.
Resilience and its related factors among women with breast cancer
Authors: Ostadi-sefidan Hossein , Faroughi Farnaz , Fathnezhad-Kazemi Azita 
Published: September 2023

Objectives
Breast cancer is the most challenging disease, and the level of resilience in patients determines their ability to cope with the arising stress. There is relatively limited information on the resilience of patients in clinical settings. Our study aims were to evaluate the extent of resilience and identify factors that predict resilience in women with breast cancer.

Patients and methods
A cross-sectional study was conducted with the participation of 218 women with breast cancer who were referred to the Oncology clinic in 2022. The participants completed three scales, namely the Conner-Davidson Resilience, Schneider’s Life Expectancy, and the Multidimensional Scale of Perceived Social Support, along with sociodemographic information. Descriptive statistics, bivariate, and multiple linear regression were used to explore the predictors of resilience.

Result
The mean (SD) scores for resilience, social support, and hope were 59.22 (17.25), 38.53 (6.19), and 59.37 (16.68), respectively. Based on analysis 50.8% of the variations in resilience could be explained by 6 variables including social support, hope, women’s age, employment, and income status as well as the stage of illness (R2
adj = 0.508, P < 0.001). Employment status and disease stage did not show a significant relationship with resilience and social support was the factor with the highest impact on resilience (β = 0.516, P < 0.001).

Conclusion
Our study showed social support, hope, age, and income level predict significant resilience in women with breast cancer. The findings emphasize the importance of fostering strong support networks, cultivating a hopeful mindset, embracing life’s transitions, and addressing financial considerations in the pursuit of enhanced resilience.
Individualised positive end-expiratory pressure titrated intra-operatively by electrical impedance tomography optimises pulmonary mechanics and reduces postoperative atelectasis
Authors: Ma Xiaojing , Fu Yunke , Piao Xiangmei , De Santis Santiago Roberta Ribeiro , Ma Libin , Guo Ying , Fu Qiang , Mi Weidong , Berra Lorenzo , Zhang Changsheng 
Published: September 2023

BACKGROUND
A protective intra-operative lung ventilation strategy has been widely recommended for laparoscopic surgery. However, there is no consensus regarding the optimal level of positive end-expiratory pressure (PEEP) and its effects during pneumoperitoneum. Electrical impedance tomography (EIT) has recently been introduced as a bedside tool to monitor lung ventilation in real-time.

OBJECTIVE
We hypothesised that individually titrated EIT-PEEP adjusted to the surgical intervention would improve respiratory mechanics during and after surgery.

DESIGN
Randomised controlled trial.

SETTING
First Medical Centre of Chinese PLA General Hospital, Beijing.

PATIENTS
Seventy-five patients undergoing robotic-assisted laparoscopic hepatobiliary and pancreatic surgery under general anaesthesia.

INTERVENTIONS
Patients were randomly assigned 2 : 1 to individualised EIT-titrated PEEP (PEEPEIT; n = 50) or traditional PEEP 5 cmH2O (PEEP5 cmH2O; n = 25). The PEEPEIT group received individually titrated EIT-PEEP during pneumoperitoneum. The PEEP5 cmH2O group received PEEP of 5 cmH2O during pneumoperitoneum.

MAIN OUTCOME MEASURES
The primary outcome was respiratory system compliance during laparoscopic surgery. Secondary outcomes were individualised PEEP levels, oxygenation, respiratory and haemodynamic status, and occurrence of postoperative pulmonary complications (PPCs) within 7 days.

RESULTS
Compared with PEEP5 cmH2O, patients who received PEEPEIT had higher respiratory system compliance (mean values during surgery of 44.3 ± 11.3 vs. 31.9 ± 6.6, ml cmH2O−1; P < 0.001), lower driving pressure (11.5 ± 2.1 vs. 14.0 ± 2.4 cmH2O; P < 0.001), better oxygenation (mean P
aO2/FiO2 427.5 ± 28.6 vs. 366.8 ± 36.4; P = 0.003), and less postoperative atelectasis (19.4 ± 1.6 vs. 46.3 ± 14.8 g of lung tissue mass; P = 0.003). Haemodynamic values did not differ significantly between the groups. No adverse effects were observed during surgery.

CONCLUSION
Individualised PEEP by EIT may improve intra-operative pulmonary mechanics and oxygenation without impairing haemodynamic stability, and decrease postoperative atelectasis.

TRIAL REGISTRATION
Chinese Clinical Trial Registry (www.chictr.org.cn) identifier: ChiCTR2100045166.
An Experimental Model Exhibiting Anterograde and Retrograde Vascular Occlusion of Facial Fillers to Avoid Vision Loss
Authors: Scott Gabriel , Khonda Meghana , Hsu Tammy , Rivkin Alexander , Frank Konstantin , Fezza John , Woodward Julie 
Published: September 2023

Background:
Facial filler injection techniques that help decrease the risk of vascular occlusion are an important growing area of study. This study demonstrates a model of injecting fillers into a simulated bifurcated arterial system, using different sized needle gauges at a constant injection pressure.

Methods:
Three facial fillers were injected into a bifurcated intravenous tubing with continuous irrigation at a constant pressure to simulate a vascular system. Videography was used to observe for retrograde flow through the simulated supratrochlear artery to the bifurcation point, where the filler was redirected by anterograde flow into the branch representing the ophthalmic artery.

Results:
Filler injection with retrograde flow to the bifurcation occurred with all the 27G needle trials. In comparison, the 30G needle trials were only able to reach the bifurcation point in three of the nine trials. The average time to the bifurcation point with subsequent ophthalmic artery anterograde flow with the 27G and 30G needles were 8.44 (95% confidence interval ±2.06) and 33.33 (95% confidence interval ±16.56) seconds, respectively.

Conclusions:
Larger 27G needles consistently reached retrograde flow and the bifurcation point faster than 30G needles. This study suggests thinner needles may be less likely to cause retrograde occlusion.