bluuebunny/crossref_metadata_2025_split huggingface dataset:
V-049 THE IMPORTANCE OF PROCTORING- MISSING THE “TEN GOLDEN RULES” OF TAPP
Authors: Capoccia Giovannini S , Stabilini C , Muysoms F 
Published: May 2023

Abstract
Claus in 2020 published the “Ten golden Rules” for a minimally Invasive safe approach to the Myopectineal Orifice.
During the first proctoring session of a TAPP procedure for the repair of a left side inguinal hernia we revised the application of the rules by the trainee.
The proctor invited the trainee to study the paper before the session of surgery.
The first and the last 3 rules were followed by the trainee but there was a lack of the 4-5-6-7 rules.
The knowledge of the anatomy of the inguinal region allows the surgeon to create a preperitoneal box for a mesh at least 15×15cm covering all the possible origins for hernia.
In particular we focused our attention to the rule 7. The trainee was missing to check the emptiness of the deep inguinal ring that was covered, in the iliopubic tract, by fat sliding to the scrotal region. After dissection a big cord lipoma was reduced in the abdomen.
Missing this rule should be a problem because the patient could feel,after the inguinal hernia repair, a bulging and discomfort in the inguinal region.
The imaging could not be helpful and the clinical visit could report a “false Positive” for the presence of bulging without a real hernia.
In a similar case we reoperate a man after a TAPP procedures for a bulging in inguinal region, pain and discomfort miming a recurrence but we only found a large cord lipoma that we resected.
V-053 USE OF ABDOMINAL FASCIA TRANSPLANTATION FOR COMPLEX GIANT INCISIONAL HERNIA AFTER LIVER TRANSPLANT
Authors: Vega V , Jiménez C , Justo I 
Published: May 2023

Abstract
Incisional hernias are a well-known complicationafter liver transplantation, with an incidence of up to 15%. Conventional closure techniques such as synthetic or biological meshes do not have proper results, probably due to a variety of factors including tension in a definitive wall closure and the use of immunosuppressive drugs that can cause necrosis and wound infection. Alternative techniques such as a complete abdominal fascia transplantation can sometimes be needed.
We present the case of a 57-year-old man with a history of liver transplantation due to HCV Cirrhosis, Portal Thrombosis and Pulmonary Hypertension.
The patient developed a hernia of the Mercedes scar with a large fascial defect that caused him pain and obstructive symptoms.
Surgical intervention was performed for hernia repair. During surgery, a large aponeurotic defect was identified with a ring of 25×15cm associated with an adhesion syndrome within the hernial sac.
During surgery, the hernial sac was released, followed by release of the anterior aponeurosis and peritoneal closure. An abdominal wall transplant was performed from a 56-year-old donor after the graft had been preserved for 10 days in Celsior® at 4°. The fascial graft was placed to cover the abdominal wall defect and sutured to the edges of the recipient's fascia, using 4 interrupted 2-0 polypropylene non absorbable stitches.
This patient's loss of domain of the abdominal cavity, associated with the existing vascular complications, were more than sufficient reasons to choose this technique.
The patient's postoperative course was uneventful, but developed bulging during follow-up, without any additional complications.
Evaluation of functional and aesthetic outcomes of free dermal fat graft versus superficial musculoaponeurotic system flap after superficial parotidectomy: randomized clinical trial
Authors: Fawzy Ahmed , Balbaa M Ashraf , Hagag Mahmoud 
Published: May 2023

Abstract

Background
Parotidectomy is the standard procedure for treatment of many parotid lesions; however, it has several drawbacks. Facial asymmetry and Frey’s syndrome are the most annoying complications to patients. Insertion of interpositioning grafts into the parotidectomy bed can decrease these complications significantly. Free dermal fat graft (FDFG) and superficial musculoaponeurotic system (SMAS) flap have very promising results. This RCT aimed to compare these two techniques regarding functional and aesthetic outcomes.

Methods
Between February 2016 and October 2021, adult patients undergoing superficial conservative parotidectomy in a single centre for a benign indication were randomized into two equal groups using a closed envelope method. In one group, FDFG was inserted at the parotidectomy bed, whereas, in the other group, SMAS flap was performed. Preoperative, operative, and postoperative data were recorded and analysed. The primary outcome was the development of Frey's syndrome.

Results
Seventy-eight patients were randomized into two equal groups of 39 patients. There was no significant difference between the two groups regarding development of Frey's syndrome. There was no significant statistical difference between study groups regarding demographic data, co-morbidities, parotid pathologies, specimen volumes, total operating time, and postoperative complications. A tendency for over correction was observed in FDFG and under correction in SMAS flap. There was no statistically significant difference between the study groups regarding the patients’ aesthetic satisfaction with the majority displaying excellent satisfaction with no poor results.

Conclusion
FDFG and SMAS flap are simple, rapid, and reliable procedures and are effective in improving both functional and aesthetic outcomes post-parotidectomy. They have comparable results; however, selection of either procedure can be determined according to patient and tumour characteristics.
Registration number: NCT05452837 (http://www.clinicaltrials.gov)
Initial systolic blood pressure associates with systemic inflammation, myocardial injury, and outcomes in patients with acute coronary syndromes
Authors: Winzap Patric A , Kraler Simon , Obeid Slayman , Wenzl Florian A , Templin Christian , Klingenberg Roland , von Eckardstein Arnold , Roffi Marco , Muller Olivier , Räber Lorenz , Lüscher Thomas F ,   SPUM-ACS investigators, Mach F , Matter C , Rodondi N , Nanchen D , Carballo D , Gencer B , Pfisterer Matthias , Kappenberger Lukas , Moccetti Tiziano , Meyer Philippe , Meier Pascal , Iglesias Juan , Rigamonti Fabio , Kälin-Weeke Carola , Peereboom Isabelle , Seiler Monika 
Published: May 2023

Abstract

Aims
Outcomes after acute coronary syndromes (ACS) are determined by baseline risk profiles, including initial systolic blood pressure (sBP) levels. Herein, we aimed to characterize ACS patients stratified by initial sBP levels and study their relation to inflammation, myocardial injury and post-ACS outcomes.

Methods and results
We analysed 4724 prospectively recruited ACS patients according to invasively assessed sBP (&lt;100, 100–139, and ≥140 mmHg) at admission. Biomarkers of systemic inflammation [high-sensitivity C-reactive protein (hs-CRP)] and myocardial injury [high-sensitivity cardiac troponin T (hs-cTnT)] were measured centrally. Major adverse cardiovascular events (MACE; composite measure of non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death) were externally adjudicated. Leukocyte counts, hs-CRP, hs-cTnT, and creatine kinase (CK) levels decreased from low to high sBP strata (ptrend &lt; 0.001). Patients with sBP &lt; 100 mmHg developed more often cardiogenic shock (CS; P &lt; 0.001), and had a 1.7-fold increased multivariable-adjusted MACE risk at 30 days (HR 1.68, 95% CI 1.05–2.69, P = 0.031) which did not persist at one year (HR 1.38, 95% CI 0.92–2.05, P = 0.117). Those with sBP &lt; 100 mmHg and CS showed a higher leukocyte count (P &lt; 0.001), an increased neutrophil-to-lymphocyte-ratio (P = 0.031), and higher hs-cTnT and CK levels relative to those without CS (P &lt; 0.001 and P = 0.002, respectively), whereas hs-CRP levels did not differ. Patients who developed CS had a 3.6- and 2.9-fold increased MACE risk at 30 days (HR 3.58, 95% CI 1.77–7.24, P &lt; 0.001) and at one year (HR 2.94 95% CI, 1.57–5.53, P &lt; 0.001), which was intriguingely attenuated after controlling for distinct inflammatory profiles.

Conclusion
In patients with ACS, proxies of systemic inflammation and myocardial injury are inversely associated with initial sBP levels, with highest biomarker levels observed in those &lt;100 mmHg. If linked to high levels of cellular inflammation, these patients are prone to develop CS and are at high MACE and mortality risk.
Beta 2-microglobulin: case report of a rare cause of cardiac amyloidosis
Authors: Haslett Jack J , Patel Jignesh K , Kittleson Michelle M 
Published: May 2023

Abstract

Background
Cardiac amyloidosis is caused by the deposition of misfolded proteins in the myocardium. The majority of cases of cardiac amyloidosis is caused by misfolded transthyretin or light chain proteins. In this case report, we discuss a case of a rare form of cardiac amyloidosis related to beta 2-microglobulin (B2M) in a patient not on dialysis.

Case summary
A 63-year-old man was referred for workup of possible cardiac amyloidosis. Serum and urine immunofixation electrophoresis demonstrated no monoclonal bands, and the serum kappa/lambda light chain ratio was normal, excluding light chain amyloidosis. Bone scintigraphy imaging showed diffuse radiotracer uptake in the myocardium, and genetic testing of the Transthyretin gene was negative for variants. This workup was consistent with wild-type transthyretin cardiac amyloidosis. The patient, however, later underwent endomyocardial biopsy due to factors inconsistent with this diagnosis, including a young age of presentation and a strong family history of cardiac amyloidosis despite no variants in the Transthyretin gene. This showed B2M-type amyloidosis, and genetic testing of the B2M gene showed a heterozygous Pro32Leu (p. P52L) mutation. The patient underwent heart transplantation with normal graft function 2 years post transplant.

Discussion
While contemporary advancements allow for the non-invasive diagnosis of transthyretin cardiac amyloidosis with positive bone scintigraphy and negative monoclonal protein screen, clinicians should be aware of rarer forms of amyloidosis where endomyocardial biopsy is required to make the diagnosis.
eHealth for maintenance cardiovascular rehabilitation: a systematic review and meta-analysis
Authors: Heimer Melina , Schmitz Sandra , Teschler Marc , Schäfer Hendrik , Douma Emma R , Habibovic Mirela , Kop Willem J , Meyer Thorsten , Mooren Frank C , Schmitz Boris 
Published: May 2023

Abstract

Aims
To provide a quantitative analysis of eHealth-supported interventions on health outcomes in cardiovascular rehabilitation (CR) maintenance (phase III) in patients with coronary artery disease (CAD) and to identify effective behavioural change techniques (BCTs).

Methods and results
A systematic review was conducted (PubMed, CINAHL, MEDLINE, and Web of Science) to summarize and synthesize the effects of eHealth in phase III maintenance on health outcomes including physical activity (PA) and exercise capacity, quality of life (QoL), mental health, self-efficacy, clinical variables, and events/rehospitalization. A meta-analysis following the Cochrane Collaboration guidelines using Review Manager (RevMan5.4) was performed. Analyses were conducted differentiating between short-term (≤6 months) and medium/long-term effects (&gt;6 months). Effective behavioural change techniques were defined based on the described intervention and coded according to the BCT handbook. Fourteen eligible studies (1497 patients) were included. eHealth significantly promoted PA (SMD = 0.35; 95%CI 0.02–0.70; P = 0.04) and exercise capacity after 6 months (SMD = 0.29; 95%CI 0.05–0.52; P = 0.02) compared with usual care. Quality of life was higher with eHealth compared with care as usual (SMD = 0.17; 95%CI 0.02–0.32; P = 0.02). Systolic blood pressure decreased after 6 months with eHealth compared with care as usual (SMD = −0.20; 95%CI −0.40–0.00; P = 0.046). There was substantial heterogeneity in the adapted BCTs and type of intervention. Mapping of BCTs revealed that self-monitoring of behaviour and/or goal setting as well as feedback on behaviour were most frequently included.

Conclusion
eHealth in phase III CR is effective in stimulating PA and improving exercise capacity in patients with CAD while increasing QoL and decreasing systolic blood pressure. Currently, data of eHealth effects on morbidity, mortality, and clinical outcomes are scarce and should be investigated in future studies.

Registration
PROSPERO: CRD42020203578.
Using quotients as a mentor to facilitate the success of underrepresented students
Authors: Neikirk Kit , Barongan Taylor , Rolle Tiffany , Garza Lopez Edgar , Marshall Andrea , Beasley Heather K , Crabtree Amber , Spencer Elsie C , Shuler Haysetta , Martinez Denise , Murray Sandra , Vang Chia , Jenkins Felysha , Damo Steven , Vue Zer 
Published: May 2023

Abstract
Choosing a mentor requires a certain level of introspection for both the mentor and the mentee. The dynamics of mentorship may change depending on the academic status of the mentee. Regardless, mentors should help their trainees grow both academically and professionally. The success of an individual in the fields of science, technology, engineering, mathematics, and medicine (STEMM) depends on more than intellectual capacity; a holistic view encompassing all factors that contribute to scientific achievement is all-important. Specifically, one new method scientists can adopt is quotients, which are scales and techniques that can be used to measure aptitude in a specific area. In this paper, we focus on these factors and how to grow one’s adversity quotient (AQ), social quotient (SQ), and personal growth initiative scale (PGIS). We also look at how mentors can better understand the biases of their trainees. In addressing this, mentors can help trainees become more visible and encourage other trainees to become allies through reducing biases.
Effectiveness of Sawdust and Rice Straw Mulch Strips to Control Runoff and Sediment Yield in Skid Trails
Authors: Solgi Ahmad , Cerdà Artemi , Masumian Ali , Rabiee Mohammad Reza Sheykh , Behjou Farshad Keivan , Vojoodi Razieh Ghasemi 
Published: May 2023

AbstractMulches can be effective for reducing sediment loss and erosion from forest harvesting activities. This study evaluates the use of rice straw and sawdust as mulch covers for skid trails on clay loam soil. The treatments with three replications each included combinations of two levels of slope gradient (≤ 20% and &gt; 20%), three types of mulch cover (bare soil, sawdust, and rice straw cover), three levels of mulching application schemes (1/3, 2/3, and 3/3 of the plot length), and two levels of surface cover rates (50% and 70%). Increasing levels of mulch cover had significantly lower runoff and sediment yields throughout the trails. The average runoff rates and sediment yield from the machine operating trails treated with sawdust cover (SC) (30.2 l and 2.7 g m-2) were lower than on trails covered with rice straw mulch (RSC) (36.8 l and 3.5 g m-2), which were, in turn, lower than on untreated bare soil (BS) trail sectors (48.80 l and 5.34 g m-2). Overall, mulching was more effective when applied over the entire plot length than over the 1/3 and 2/3 plots length strips, both in terms of runoff and sediment yield.
A workflow reproducibility scale for automatic validation of biological interpretation results
Authors: Suetake Hirotaka , Fukusato Tsukasa , Igarashi Takeo , Ohta Tazro 
Published: May 2023

Abstract

Background
Reproducibility of data analysis workflow is a key issue in the field of bioinformatics. Recent computing technologies, such as virtualization, have made it possible to reproduce workflow execution with ease. However, the reproducibility of results is not well discussed; that is, there is no standard way to verify whether the biological interpretation of reproduced results is the same. Therefore, it still remains a challenge to automatically evaluate the reproducibility of results.

Results
We propose a new metric, a reproducibility scale of workflow execution results, to evaluate the reproducibility of results. This metric is based on the idea of evaluating the reproducibility of results using biological feature values (e.g., number of reads, mapping rate, and variant frequency) representing their biological interpretation. We also implemented a prototype system that automatically evaluates the reproducibility of results using the proposed metric. To demonstrate our approach, we conducted an experiment using workflows used by researchers in real research projects and the use cases that are frequently encountered in the field of bioinformatics.

Conclusions
Our approach enables automatic evaluation of the reproducibility of results using a fine-grained scale. By introducing our approach, it is possible to evolve from a binary view of whether the results are superficially identical or not to a more graduated view. We believe that our approach will contribute to more informed discussion on reproducibility in bioinformatics.
Simulating Timber Harvest to Assess Potential Impacts to Forest Wildlife Habitat on State Lands in Minnesota, USA
Authors: Gifford Tyler S , Zobel John M , Shartell Lindsey M , Hillard Scott C 
Published: May 2023

Abstract
Forest management and planning efforts often account for many resource objectives and benefits, including wildlife habitat. In particular, newly approved management goals and harvest targets on state lands in Minnesota were examined for their potential impact on wildlife habitat. Using a list of stands planned for potential harvest and a regional wildlife habitat model, habitat effects were assessed for 173 native, forest-dependent wildlife species on state lands. Leveraging forest type– and region-specific harvest probabilities and post-examination lag times to harvest, three simulation efforts covering the spectrum of possible outcomes were used to estimate habitat change from 2020 to 2030. In the most realistic simulation, 31.8% of species exhibited statistically significant positive habitat change, 11.6% significant negative change, and 56.6% nonsignificant or no change. Compared with simulations reflecting more extreme levels of harvest, the realistic simulation showed the greatest compromise between negative and positive shifts in habitat. Results reflect tradeoffs in wildlife habitat preferences such that changes in management that positively affect certain species often negatively affect others. Tradeoffs may be addressed by providing flexibility to individual managers where a targeted prescription is justified for a specific species, all while continuing broad statewide forest management goals.
The role of ultrasound quantitative parameters in the assessment of acute radiodermatitis after breast-conserving surgery
Authors: Chen Wenqin , Lu Wenjuan , Yuan Ya , Li Lu , Deng Hongyan , Ye Xinhua 
Published: May 2023

Abstract
This study aimed to assess the severity of acute radiodermatitis (ARD) by ultrasound quantitative parameters and to try to identify the influencing factors of skin toxicity. A total of 55 patients who underwent radiotherapy after unilateral breast-conserving surgery (BCS) were included in the study. The irradiated side of the breast was used as the research object and the quantitative ultrasound parameters (skin thickness, shear wave elasticity) were evaluated before radiotherapy, every week during radiotherapy. Two weeks after radiotherapy, the patients were divided into two groups, according to the World Health Organization scoring standard: mild (0–2 grade) and severe (3–4 grade). The differences in the parameters between the groups and the changes during radiotherapy were compared, and the relationship between these parameters and the severity of ARD was analyzed. In addition, some clinical factors that may affect ARD were also included in our study. Ninety-eight percent of patients developed different degrees of ARD, and Group 2 accounted for ~31%. At the end of 5 weeks of radiotherapy, the difference in thickness between the two groups was statistically significant (P &lt; 0.05). There was no significant change in the elastic modulus of breast skin between the two groups (P &gt; 0.05). Body mass index &gt;25 kg/m2, breast thickness ≥18 mm, skin basic elastic modulus &lt;23 kPa and skin thickness increment &gt;0.3 mm were considered to be associated with severe skin reactions (P &lt; 0.05). Ultrasound can be a useful tool for the non-invasive and objective assessment of skin changes during radiotherapy, documenting quantitative changes in the skin of breast cancer patients following BCS undergoing radiotherapy.
The incidence and prevalence of IgA nephropathy in Europe
Authors: Willey Cynthia J , Coppo Rosanna , Schaefer Franz , Mizerska-Wasiak Malgorzata , Mathur Mohit , Schultz Michaela J 
Published: May 2023

ABSTRACT

Background
This study aimed to determine the incidence and prevalence of immunoglobulin A nephropathy (IgAN) in Europe based on high-quality data from national registries.

Methods
IgAN incidences were obtained from a literature review of European studies of national kidney biopsy registry data in which IgAN diagnosis was biopsy-verified using contemporary techniques. Studies were eligible for the main analysis if published from 1990 to 2020. IgAN point prevalence was defined as the annual IgAN incidence multiplied by the estimated duration of disease. Incidence and prevalence estimates were made for three pooled populations: (i) patients of all ages; (ii) pediatric patients; and (iii) elderly patients.

Results
Across 10 European countries, the estimated annual IgAN incidence was 0.76 per 100 000 in patients of all ages. The corresponding pooled IgAN point prevalence was 2.53 per 10 000 (95% confidence interval: 2.51–2.55), ranging from 1.14 per 10 000 in Spain to 5.98 per 10 000 in Lithuania. Applied to 2021 population estimates, the number of expected prevalent IgAN cases was 47 027 across all 10 countries and ranged from 577 in Estonia to 16 645 in Italy. Among pediatric patients, IgAN incidence was 0.20 per 100 000 children and IgAN point prevalence was 0.12 per 10 000 children. Among elderly patients, IgAN incidence was 0.30 per 100 000 and IgAN point prevalence was 0.36 per 10 000.

Conclusions
Based on high-quality data from European national registries, IgAN point prevalence was estimated at 2.53 per 10 000 in patients of all ages. Prevalence was considerably lower in pediatric and elderly populations.
Comprehensive conservative care: what doctors say, what patients hear
Authors: Hamroun Aghiles , Glowacki François , Frimat Luc 
Published: May 2023

ABSTRACT
The demographic evolution of patients with advanced chronic kidney disease (CKD) has led to the advent of an alternative treatment option to kidney replacement therapy in the past couple of decades. The KDIGO controversies on Kidney Supportive Care called this approach “comprehensive conservative care” (CCC) and defined it as planned holistic patient-centered care for patients with CKD stage 5 that does not include dialysis. Although the benefit of this treatment option is now well-recognized, especially for the elderly, and comorbid and frail patients, its development remains limited in practice. While shared decision-making and advance care planning represent the cornerstones of the CCC approach, one of the main barriers in its development is the perfectible communication between nephrologists and patients, but also between all healthcare professionals involved in the care of advanced CKD patients. As a result, a significant gap has opened up between what doctors say and what patients hear. Indeed, although CCC is reported by nephrologists to be widely available in their facilities, few of their patients say that they have actually heard of it. The objectives of this review are to explore discrepancies between what doctors say and what patients hear, to identify the factors underlying this gap, and to formulate practical proposals for narrowing this gap in practice.