bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Uncanny Valley Phenomenon: Where Is the Categorical Boundary Between Categorization Difficulty and Categorization Failure?
Authors: Yamada Yuki , Sasaki Kyoshiro 
Published: January 2025

The uncanny valley phenomenon has been widely discussed in relation to human-like entities, but some studies suggest it also applies to inanimate stimuli. Recently, Sasaki et al.[1] used abstract figures as stimuli and argued that categorization failure, rather than difficulty, underlies the uncanny valley phenomenon. While we appreciate their interesting proposal, we clarify that categorization difficulty and failure are not mutually exclusive accounts. We critically examine the findings of Sasaki et al.[1], questioning the lack of direct evidence for categorization failure and their reliance on non-significant results. Furthermore, we propose that the (difficulty-originated) "stranger-avoidance" hypothesis remains a viable alternative, suggesting that categorization difficulty leads to negative responses. Future research should integrate these perspectives to achieve a more comprehensive understanding. Our commentary highlights the need for collaboration and theoretical refinement in uncanny valley research.
Pengembangan Alat Ukur Hidrometri Berbasis 5 Jenis Sensor Untuk Deteksi Konsentrasi Sedimen Dalam Upaya Mitigasi Bencana Banjir Sungai Bomo
Authors: Erwanto Zulis , Iranata Data , Maulana Mahendra Andiek , Sasmita Ginanjar Eka , Handoko Siswo , Habibi Hida Jaya , Hasyim Nur Cholik 
Published: January 2025

Peristiwa banjir pada DAS bertipe bulu burung di Banyuwangi dapat membawa dampak tingginya angkutan sedimen dan menurunnya kualitas air. Peluapan sungai Bomo dipacu karena intensitas hujan dan kecepatan aliran tinggi sehingga berdampak erosi, degradasi, dan kekeruhan yang tinggi. Tujuan penelitian untuk pengembangan alat ukur hidrometri berbasis sensor untuk deteksi konsentrasi sedimen dalam upaya mitigasi bencana banjir di Sungai Bomo. Tahapan penelitian melalui proses rancang bangun alat ukur hidrometri berbasis sensor berupa sensor ultrasonic (water level), water flow, turbidity, TDS, dan suhu, lalu simulasi pengukuran, dan pengambilan sampel sedimen untuk diuji karakteristik fisik di laboratorium berupa uji konsentrasi sedimen, berat jenis, berat volume, analisa saringan dan hidrometer. Parameter hidrometri diuji statistik melalui sediment-discharge rating curve. Hasil pengujian karakteristik fisik sedimen sungai Bomo selama 7 hari masing-masing di bulan basah dan kering diperoleh nilai rata-rata Cu 3,88 – 6,58 dan nilai rata-rata Cc 0,62 – 1,19, berat jenis rata-rata 2,5 – 2,55 dan berat volume 1,49 – 1,57 gr/cm3. Kalibrasi pembacaan sensor TDS terhadap konsentrasi sedimen dengan nilai MAE rata-rata sebesar 0,23 reliable terhadap kondisi lapangan. Hasil sediment-discharge rating curve pada musim kering diperoleh persamaan Qs_dry=35.653.(Qw)^0.9315 (R2 = 0.8269). Pada musim basah diperoleh persamaan Qs_wet=16.501.(Qw )^1.3719 (R2= 0.9336). Pada saat musim kering perlu waspada karena lahan lebih erosif karena nilai a > 26 yaitu 35.653 yang mengindikasikan laju erosi tinggi dan dapat menyebabkan banjir dan longsor. Alat ukur hidrometri berbasis sensor layak dikembangkan sebagai alat deteksi konsentrasi sedimen sebagai indikator muatan sedimen dalam upaya mitigasi bencana banjir dan tindakan konservasi lahan.
Sifat Fisik dan Mekanik Bata Merah Kabupaten Majene untuk Konstruksi Dinding Rumah Sederhana Tahan Gempa
Authors: Sainuddin Sainuddin , Suryani Herni 
Published: January 2025

Batu bata merah digunakan sebagai bahan non-struktural untuk dinding pembatas gedung. Dibutuhkan peningkatan kualitas produk yang dihasilkan karena penggunaan batu bata di Kabupaten Majene sampai saat ini tidak seimbang dengan kontrol kualitas yang ada di lapangan. Penelitian ini bertujuan untuk menentukan sifat fisik dan mekanik batu bata merah di Kabupaten Majene yang disesuaikan dengan SNI 15-2094-2000. Sebanyak tujuh penjual batu bata di Kabupaten Majene dipilih untuk menganalisis sifat fisik dan mekanik dari bahan uji. Pemeriksaan awal di lapangan meliputi pemeriksaan campuran tanah yang digunakan, lama pengeringan, jenis pembakaran, dan teknik pembakaran. Sifat tampak, ukuran bata merah, dan kandungan garam juga diperiksa secara fisik. Selain itu, dilakukan pemeriksaan sifat mekanik seperti pengujian kerapatan semu, penyerapan air, dan kuat tekan. Hasil menunjukkan sifat fisik semua lokasi tidak memenuhi standar SNI 15-2094-2000 tetapi hasil pemeriksaan sifat mekanik sebanyak 9 lokasi memenuhi kriteria mutu kuat tekan kelas 150 sesuai SNI 15-2094-2000
First report of some praying mantids (Insecta, Mantodea) from Mizoram state, India
Authors: Kamila A. P. , Sureshan P. M. , Kumar Sumit , Das Debasis 
Published: January 2025

Seven species of mantids viz. Humbertiella affinis Giglio-Tos, 1917, Acromantis montana Giglio-Tos, 1915, Anaxarcha acuta Beier, 1963, Creobroter laevicollis (Saussure, 1870), Statilia maculata (Thunberg, 1784), Statilia nobilis (Brunner de Wattenwyl, 1893) and Tenodera aridifolia (Stoll, 1813) are newly reported from Mizoram state, India.
BEDIPOLI : Implementing an Educational Game Monopoly to Enhance Digital Ethics Among Elementary School Students in Purwakarta, Indonesia
Authors: Novianti Putri Ade , Hikmawan Rizki , Fajrussalam Hisny 
Published: January 2025

This research aims to enhance elementary school students’ comprehension of digital ethics by employing Monopoly as the medium for Educational Game Tools (APE). This study used a quantitative approach with a pre-experimental design featuring a one-group pre-test and post-test, with the sample selected through purposive sampling. The instrument design involved creating assessment tools validated by six experts. The learning media included 30 questions on digital ethics comprehension, with validity assessed using the content validity ratio (CVR). To test the hypothesis, a Wilcoxon Signed-Ranks Test was applied to compare the pre-test and post-test scores. Pre-test and post-test instruments were adapted from the Ministry of Communication and Information Technology’s “Status of Digital Literacy in Indonesia 2020,” focusing on communication skills and technology ethics. The results revealed that initial assessments indicated a low understanding of digital ethics among students, with 18 out of 39 needing to demonstrate mastery before the APE implementation. However, post-implementation evaluations showed that only one student did not achieve mastery, with significant overall improvement and heightened enthusiasm for learning, highlighting the APE’s effectiveness. The study suggests that incorporating educational game tools (APE) into learning methods can significantly enhance students’ understanding of digital ethics.
Pengembangan Game Edukasi Pengenalan Kosakata Bagi Siswa Penyandang Tunarungu di Sekolah Luar Biasa (SLB) Negeri Kanatang
Authors: Kornelis Vanesa Widia Ayusi , Pekuwali Arini Aha , Sitaniapessy Desy Asnath 
Published: January 2025

Pendidikan merupakan hak fundamental bagi setiap individu, termasuk anak-anak dengan kebutuhan khusus seperti siswa Tunarungu di Sekolah Luar Biasa (SLB) Negeri Kanatang, Sumba Timur. Tantangan utama di sekolah ini adalah keterbatasan kosakata siswa tunarungu yang menghambat kemampuan mereka dalam berbahasa dan berkomunikasi. Penelitian ini difokuskan pada pengembangan game edukasi berbasis android dengan menggunakan metode Game Development Life Cycle (GDLC) dan Algoritma Fisher Yates Shuffle untuk mengacak latihan soal. Melalui pendekatan multimedia interaktif, game ini diharapkan dapat memperkaya pengalaman belajar siswa, memfasilitasi pemahaman kosakata serta meningkatkan inklusi pendidikan. Kontribusi penelitian ini terletak pada pengembangan teknologi pembelajaran inklusif di Indonesia untuk mengatasi kesenjangan akses dan mendukung kebutuhan pendidikan khusus. Dengan demikian, penelitian ini tidak hanya meningkatkan kualitas pembelajaran di SLB Negeri Kanatang, tetapi juga memperluas cakupan pendidikan yang setara bagi semua anak termasuk mereka yang menghadapi tantangan pendengaran. Pengujian aplikasi menggunakan metode Black Box Testing dan mendapatkan hasil bahwa fitur-fitur yang ada pada game edukasi yang dibangun telah sesuai dengan hasil yang diharapkan. Begitu juga dengan pengujian dengan menggunakan System Usability Scale (SUS), perhitungan yang dilakukan mendapatkan hasil skor rata-rata sebesar 84,25 sehingga aplikasi yang sudah dibangun ini sudah sangat baik dan layak digunakan. Berdasarkan penelitian kepada siswa berjumlah 10 siswa didapatkan game edukasi pengenalan kosakata ini mampu menaikkan nilai siswa Penyandang Tunarungu di Sekolah Luar Biasa (SLB) Negeri Kanatang sebesar 17% dengan nilai rata-rata post-test adalah 88.
Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia
Authors: Huang Lin , Guo Rui , Lin Jingxian , Li Xiaowei , Li Zhicong , Zhang Limei , Li Wenting , Xue Rui , Zhang Cheng , Feng Xiaosan , Li Xiaobin 
Published: January 2025

IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST) 45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. In Hainan and Guangzhou of China, the ST45-MRSA was mainly associated with t116.MethodsThe MRSA strain SA2107 was isolated from the sputum of a 5-year-old child with pneumonia. The whole genome of SA2107 was sequence using Illumina (Novaseq 6000) and PacBio (Sequel IIe) sequencers, and the sequences were assembled using hybrid assembly. The carriage of antibiotic resistance genes, virulence genes, and mobile genetic elements were identified using bioinformatics tools. The comparative genomic analyses of MRSA strain SA2107 with other MRSA strains worldwide were performed.FindingsThe genome size of ST45-SCCmec IVa (2B)-t116 MRSA strain SA2107 was ~2.9 Mb. Mobile genetic elements analysis of SA2107 revealed two plasmids (30,064-bp pSA2107-1 and 8,033-bp pSA2107-2), three prophages, two integrative and conjugative elements (ICEs), and two insertion sequences (ISs, IS431 and IS1272). The SCCmec IVa (2B) carried by SA2107 contained the class B mec gene complex (IS431-mecA-ΔmecR1-IS1272) and type 2 ccr gene complex (ccrA2 and ccrB2). Besides mecA, another beta-lactam resistance gene blaZ was found to located on six copies of bla complex (blaZ, blaR1, and blaI) on the chromosome of SA2107. Three kinds of virulence factors were detected on the chromosome of SA2107, including genes encoding toxins, exoenzyme, and immune-modulating protein. Notably, the three prophages harbored by the chromosome of SA2107 all carried virulence genes.ConclusionThus far, only three complete genomes available for ST45-SCCmec IVa (2B)-t116 strain from United States, Germany, and Australia, respectively. The strain SA2107 was the first complete genome data (CP104559) from China for ST45-SCCmec IVa (2B)-t116 MRSA.
Identifying etiologies of heart failure using non-contrast cardiac magnetic resonance imaging: cine imaging, T1 and T2 mapping, and texture analysis for T1 mapping
Authors: Amano Yasuo , Suzuki Yasuyuki , Tang Xiaoyan , Ando Chisato 
Published: January 2025

ObjectiveThe aim of this retrospective study was to evaluate the usefulness of non-contrast cardiac magnetic resonance imaging, including cine imaging, T1 and T2 mapping, and texture analysis for T1 mapping, for identifying etiologies of heart failure (HF).MethodsForty-seven patients with HF were examined using a 1.5 T scanner. Cine imaging parameters and native T1 and T2 values at the mid-septal segment were measured. Vertical run length nonuniformity, vertical gray level nonuniformity (vGLNU), wavelet energy LL(3) and HH (4) on T1 mapping were estimated at the mid-septal segment using open-access software. Late gadolinium enhancement was investigated to help diagnose the etiologies of HF. We used Kruscal-Wallis’ with a post-hoc Steel-Dwass' test, Wilcoxon signed-ranked test, Pearson's chai square test and receiver operator curve analysis (ROC) to assess the usefulness of non-contrast CMR for identifying etiologies of HF.ResultsThere were significant differences in left ventricular end-diastolic volume (LVEDV) indexed to body surface area (LVEDVi), left ventricular myocardial mass/LVEDV, native T1, and vGLNU between dilated cardiomyopathy (DCM), hypertensive cardiomyopathy (HC) and tachycardia-induced cardiomyopathies (TIC). DCM had higher T1 and lower vGLNU than HC. When compared with TIC, DCM showed significantly higher LVEDV and LVEDVi. ROC analysis revealed that LVEDV and vGLNU provided high specificity for differentiating DCM from the other etiologies.ConclusionNative T1 mapping and its texture analysis may be valuable for differentiating between DCM and HC. Cine imaging can be useful for differentiating between DCM and TIC.
Association between cardiopulmonary bypass duration and early major adverse cardiovascular events after surgical repair of supravalvular aortic stenosis
Authors: Zhang Simeng , Wei Caiyi , Peng Bo , Lv Lizhi , Pei Fengbo , Xia Jianming , Yan Jun , Liu Jie , Wang Qiang , Shi Yi 
Published: January 2025

BackgroundPatients who underwent surgical repair of supravalvular aortic stenosis (SVAS) are at high risk for postoperative major adverse cardiovascular events (MACE). This study aimed to investigate the association between cardiopulmonary bypass (CPB) duration and MACE occurring during postoperative hospitalization or within 30 days post-surgery.MethodsPatients who underwent surgical repair of SVAS from 2002 to 2019 at Beijing Fuwai Hospital and Yunnan Fuwai Hospital were included in this study. Patients were stratified into “CPB duration &gt;2 h” and “CPB duration ≤2 h” groups based on intraoperative CPB duration. Various statistical methodologies were employed to investigate the association between CPB duration and early postoperative MACE, including multivariate adjustment, propensity score adjustment, propensity score matching, and logistic regression based on propensity score weighting.Results297 participants were included and 164 were finally matched. In the propensity score-matched cohort, CPB duration was positively associated with early postoperative MACE (odds ratio = 18.13; 95% confidence interval 2.33–140.86; P = 0.006). Consistent results were obtained in the Inverse probability of treatment-weighted, standardized mortality ratio-weighted, pairwise algorithmic-weighted, and overlap-weighted models.ConclusionPatients with CPB duration &gt;2 h were at a higher risk of early postoperative MACE compared to those with CPB duration ≤2 h. This emphasized the significance of minimizing CPB exposure for the prognosis of patients with SVAS.
Assessment of root resorption on lateral incisors after primary canine extraction treating mesioangular displaced permanent canines: a randomised controlled trial
Authors: Helal Narmin , Naaman Reem , Alamoudi Najlaa , El-Housseiny Azza , Jadu Fatima 
Published: January 2025

AimRoot resorption (RR) of the adjacent maxillary lateral incisors is considered the most common complication of displaced maxillary canines. The aim of this study was to assess the effect of interceptive extraction of the primary canines on the condition of the roots of permanent neighbouring teeth to mesioangular displaced canines (MDC). In addition, this study aimed to investigate the relationship between the position of the unerupted canine and the risk of RR in adjacent lateral incisors.DesignRandomised controlled clinical trial.MethodsEighty-five patients 9–12-year-old with MDC were allocated equally to either an extraction group (EG) or a control group (CG). Of the sample, 33 were males (38.8%), and 52 were females (61.2%). Among this sample, 81 canines (51.9%) were buccally displaced, 34 canines (21.8%) were palatally displaced, and 41 canines (26.3%) were mid-alveolar. All subjects underwent cone-beam computed tomography examination to determine the presence, stage, and level of lateral incisor root resorption (RR). Measurements were performed at T0 and repeated at a 12-month follow-up (T2).Results &amp; statisticsRoot resorption (RR) was present in 28.2% of lateral incisors at the baseline assessment (T0) and exhibited a significant increase at the 12-month follow-up (T12). This marked increase in resorption severity was evident between T0 and T12 (P = 0007), regardless of group allocation. There was a significant increase in the degree of resorption between T2 and T0, with a mean difference equals to 0.31 (0.73), P &lt; 0.0001. While there was no statistically significant difference in resorption levels between the extraction and control groups at T0 (P = 0.11), RR occurred more frequently with midalveolar (34.1%) and palatal (32.3%) displacements than with buccal displacements (23.5%). Severe resorption was observed more frequently in cases involving palatally displaced canines within both groups, but it did not reach statistical significance.ConclusionsLateral incisor root resorption (RR) progressed significantly within a 12-month period irrespective of treatment modality. RR occurred more frequently with midalveolar and palatal displacement with a trend towards increased RR severity in cases with palatally displaced canines. Early clinical evaluation and consistent monitoring is essential for early detection and potential intervention in patients with mesioangular canine displacement.
Diagnostic efficiency of exome-based sequencing in pediatric patients with epilepsy
Authors: Zou Huafang , Zhang Qian , Liao Jianxiang , Zou Dongfang , Hu Zhanqi , Li Bing , Chen Li , Wen Jialun , Zhao Xia , Zhang Victor Wei , Cao Dezhi 
Published: January 2025

ObjectiveEpilepsy, a prevalent neurological disorder, has multifaceted etiologies. Next-generation sequencing (NGS) has emerged as a robust diagnostic tool for this condition. This study aims to evaluate the detection efficiencies of different exome-based sequencing techniques.MethodsExome-based epilepsy panel tests, clinical exome sequencing (CES), and whole exome sequencing (WES) were conducted on 259 pediatric patients diagnosed with epilepsy. Single-nucleotide variants (SNVs) and copy number variants (CNVs) were interpreted based on each patient’s phenotypic presentation. Additionally, data concerning clinical symptoms, neuroimaging findings, treatment responses, and prognostic outcomes were collected and analyzed.ResultsThe overall diagnostic yield was 32.8% (85/259), with a diagnostic yield of 40.0% for exome-based epilepsy panels, 30.1% for CES, and 27.8% for WES. We identified 82 cases with pathogenic or likely pathogenic SNVs and 4 cases with pathogenic CNVs, of which one case with both SNV and CNV. The most frequently detected gene was PRRT2, present in 10.0% (9/82) of cases. Epileptic syndromes were diagnosed in 66 patients, predominantly West Syndrome, Dravet Syndrome and Genetic Epilepsy with Febrile Seizures plus.ConclusionNGS is an effective method for uncovering the genetic foundations of pediatric epilepsy, with diagnostic yields varying based on the sequencing approach used. The growing preference for WES underscores its utility in complex cases, pointing to a trend towards more tailored diagnostic strategies.
Recommendations for the primary prevention of atherosclerotic cardiovascular disease in primary care: a systematic guideline review
Authors: Bredehorst Maren , González-González Ana I. , Schürmann Lara , Firmansyah Dennis , Muth Christiane , Haasenritter Jörg , van der Wardt Veronika , Puzhko Svetlana 
Published: January 2025

IntroductionThis study systematically reviews and synthesizes recommendations from national and international clinical practice guidelines (CPGs) regarding the primary prevention of atherosclerotic cardiovascular disease (ASCVD) in adults in primary care settings.MethodsCPGs were retrieved from MEDLINE, Trip, guideline repositories, and websites of guidelines-producing societies. Two reviewers independently screened the guidelines for eligibility, assessed their quality, and extracted study characteristics and relevant recommendations for further consistency analysis. Recommendations, with their strength and evidence level, were thematically coded and clustered around clinical questions using ATLAS.ti.ResultsWe included 26 CPGs from which we extracted 581 recommendations on risk assessment, non-pharmacological, and pharmacological interventions. Twenty-one guidelines (81%) were rated as having “very good” methodological quality. We categorized the recommendations into 124 clusters. Forty-four clusters (35%) included consistent recommendations, but only four of them (3%) included highly consistent recommendations. These clusters emphasized avoiding routine prescriptions of nicotinic acid, aspirin, and fibrates for primary ASCVD prevention alone, and recommending 20 mg/day of atorvastatin for high-risk ASCVD patients. The recommendations also highlighted the importance of adhering to a Mediterranean-type diet, patient-centered counseling, and standardized risk assessment for patients over the age of 40.DiscussionThis review underscores the heterogeneity in primary ASCVD prevention recommendations and the importance of personalized strategies for at-risk individuals.Systematic review registrationPROSPERO, CRD42023394605, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023394605.
Probiotic potential and safety properties of Limosilactobacillus fermentum A51 with high exopolysaccharide production
Authors: Wei Guangqiang , Wang Daodian , Wang Teng , Wang Gao , Chai Yunmei , Li Yufang , Mei Minhui , Wang Hao , Huang Aixiang 
Published: January 2025

IntroductionExopolysaccharides (EPS) produced by Lactic acid bacteria have many health benefits and unique physicochemical properties. They are widely used in the food industry to improve viscosity, mouthfeel, and textural properties of foods. In our previous studies, Limosilactobacillus fermentum A51 (L. fermentum A51) isolated from yak yogurt exhibited high EPS production capacity and was applied to improve the texture of yogurt. In this study, whole genome sequencing analysis and corresponding in vitro assays were performed to investigate the probiotic potential and safety properties of L. fermentum A51.ResultsScanning electron microscopy (SEM) observed that L. fermentum strain A51 adhered into clusters and its colony exhibited the obvious silk drawing phenomenon. Whole genome mapping revealed that L. fermentum A51 genome is 2,188,538 bp, and with an average guanine and cytosine (GC) content of 51.28%. PGAAP annotation identified 2,152 protein-encoding genes and 58 rRNAs, 15 tRNAs, and 5 5sRNAs. Hemolysis and antibiotic resistance tests, combined with the analysis of genes involved in antibiotic resistance, virulence factor, and hemolysins, suggested that L. fermentum A51 is safe. Fifty-one carbohydrate active enzyme genes in the whole genome sequence of L. fermentum A51 were annotated by carbohydrate active enzymes (CAZymes). Furthermore, L. fermentum A51 possesses adhesion, acid tolerance, bile salt tolerance, and heat tolerance genes (srtA, tuf, Bsh, nhaC, Ntn, cfa), antioxidant (nrfA, npr, nox2, tps), antibacterial genes (Idh and Dld) EPS synthesis-related genes (glf, epsG, gtf, Wzz, Wzx, Wzy), and signal molecule A1-2 synthesis-related genes (luxS, pfs). These probiotic genes were verified by quantitative real-time PCR. In vitro assays confirmed that L. fermentum A51 showed good tolerance to simulated gastrointestinal tract (8.49 log CFU/mL), 0.3% bile salt (39.06%), and possessed adhesion (86.92%), antioxidant (70.60–89.71%), and antimicrobial activities, as well as EPS and signaling molecule AI-2 synthesis capacities.ConclusionCollectively, our findings have confirmed that L. fermentum A51 is safe and exhibits good probiotic properties, thus recommending its potential application in the production of value-added fermented dairy products.