bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a mindfulness-based interventions on stress, burnout in nurses: a systematic review and meta-analysis
Authors: Wang Qi , Wang Fang , Zhang Shurong , Liu Chaofan , Feng Yue , Chen Junzhu 
Published: August 2023

BackgroundStress in the healthcare environment causes negative effects in nurses such as burnout, anxiety, and depression. The COVID-19 pandemic has resulted in increased pressure on medical staff globally, highlighting the potential benefits of mindfulness-based interventions in reducing nurses’ stress levels. Despite numerous studies exploring the effect of mindfulness-based training on nurses, the results remain inconclusive.ObjectiveTo systematically evaluate the impact of mindfulness training on nurse’s performance and increase the certainty of existing evidence.MethodsThis study searched various databases, including EBSCO, Embase, Web of Science, PubMed, ProQuest, Scopus, Cochrane Online Library, Wanfang, SinoMed, CNKI, and VIP, for randomized controlled trials on the impact of mindfulness-based interventions for nurses up until 02 December 2022. Two investigators independently screened and extracted data from the articles, while also assessing the risk of bias. The data was analyzed using RevMan 5.4 software.ResultsThis review identified 15 studies out of the 2,171 records retrieved, consisting of a total of 1,165 participants who were randomized. Post-intervention analysis provided very-low certainty evidence of moderate effectiveness of mindfulness-based training in reducing stress [standardized mean difference (SMD) = −0.81; 95% confidence interval (CI) = −1.11 to −0.52], with no significant effect on anxiety (SMD = −0.30; 95% CI = −0.72 to 0.13) or depression (SMD = −0.24; 95% CI = −0.55 to 0.07). However, the training was effective in reducing burnout, as demonstrated by the lower scores for emotional exhaustion (SMD = −4.27; 95% CI = −5.94 to −2.59) and depersonalization (SMD = −2.89; 95% CI = −4.24 to −1.54) and higher scores for personal accomplishment (SMD = 2.81; 95% CI = 0.12 to 5.50). There was a sustained improvement in stress levels in the short-term (≤3 months), with delayed benefits for burnout. However, only two studies were available for later follow-ups, and there was no significant evidence of long-term effects.ConclusionMindfulness-based training may be a viable intervention for improving the psychological wellbeing of nurses, including reducing stress, burnout.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023387081.
Development and validation of an assessment tool for public perceptions toward drive-thru community pharmacy services in Malaysia during COVID-19
Authors: Ababneh Bayan Faisal , Ong Siew Chin , Alsaloumi Louai , Hussain Rabia 
Published: August 2023

IntroductionCommunity pharmacists' roles have expanded and undergone a significant transition over the last few years. Consequently, new and different pharmacy services, such as drive-thru pharmacy services, have emerged. Drive-thru pharmacy services began three decades ago and continued even during outbreaks such as the COVID-19 pandemic. Patients' perceptions are essential to the successful implementation and satisfaction with any new service. This study examines the reliability and validity of the assessment tool of public perceptions toward drive-thru community pharmacy services in Malaysia during COVID-19.MethodsA cross-sectional study was conducted. The developed tool consists of 28 items to evaluate believed advantages toward drive-thru community pharmacy services, believed disadvantages toward drive-thru community pharmacy services, differences between drive-thru community pharmacy services and instore drug refill services, perceptions toward drive-thru community pharmacy services and feelings regarding how the introduction of drive-thru pharmacy services may affect the image of community pharmacists. Exploratory factor analysis (EFA) was performed to identify the factors of the developed tool, and confirmatory factor analysis (CFA) evaluated the model fitness.ResultsThe EFA identified five elements and 25 items for the tool, and through CFA results, the observed model of the 25 items structure of the tool was verified as an excellent fit for the data [χ2 (265, N = 565) = 819.586, p &lt; 0.001, IFI = 0.931, CFI = 0.93, RMSEA = 0.064]. The results of the CFA indicated a good model fit between the observed model and the proposed model. The internal reliability of the entire tool and each factor was very satisfactory as Cronbach's Alpha for the whole structured tool was 0.843 and for each factor was as follows, first factor (believed advantages) = 0.909, second factor (believed disadvantages) = 0.921, third factor (differences between drive-thru and instore refill) = 0.647, fourth factor (perceptions) = 0.926, and fifth factor (feelings) = 0.681.ConclusionThe developed and validated tool would be valuable for assessing the public's perceptions of the drive-thru community pharmacy service during COVID-19 and future pandemics.
Qualitative inquiry with persons with obesity about weight management in primary care and referrals
Authors: Bailey-Davis Lisa , Pinto Angela Marinilli , Hanna David J. , Cardel Michelle I. , Rethorst Chad D. , Matta Kelsey , Still Christopher D. , Foster Gary D. 
Published: August 2023

IntroductionReferrals to evidence-based weight management in the community-commercial sector are aligned with clinical recommendations but underutilized.MethodsThis qualitative study explored patients’ perceptions and expectations about obesity treatment in primary care and referral to community-commercial sector programs. Individual semi-structured interviews were conducted with a sample of US persons with obesity via telephone. Audiotape transcripts, interviewer notes, and independent review of data by two investigators allowed for data and investigator triangulation. Transcripts were analyzed using thematic analysis.ResultsData saturation was reached with 30 participants who had a mean age of 41.6 years (SD 9.4), 37% male, 20% Black/African American and 17% Hispanic, 57% college educated, and 50% were employed full-time. Three primary themes emerged: (1) frustration with weight management in primary care; (2) patients expect providers to be better informed of and offer treatment options; and (3) opportunities and challenges with referrals to community-commercial programs.DiscussionPatients expect that providers offer personalized treatment options and referrals to effective community-commercial programs are an acceptable option. If patient-level data are shared between clinical and community entities to facilitate referrals, then privacy and security issues need attention. Future research is needed to determine feasibility of implementing clinical to community-commercial referrals for obesity treatment in the United States.
Abatacept and T-cell costimulation blockade—shifting the paradigm in the prevention of graft-versus-host disease
Authors: Chakrabarti Suparno , Jaiswal Sarita Rani 
Published: August 2023

Despite advances in transplantation techniques and immunosuppressive therapies, graft-versus-host disease (GVHD) remains a significant cause of morbidity and mortality, necessitating the use of innovative strategies for its prevention. T-cell activation plays a crucial role in the pathogenesis of GVHD, and T-cell costimulation blockade (COSBL) has emerged as a promising approach to prevent this devastating condition. This review aims to explore the concept of COSBL and its potential as a paradigm-shifting strategy in the prevention of GVHD, in the context of the existing modalities for the prevention of GVHD and the preclinical and clinical studies on COSBL. The unique property of abatacept (CTLA4Ig) is not just limited to dampening T-cell activation. The salutary effect of abatacept on natural killer (NK) cells and Tregs alike provides a unique opportunity to dissociate T-cell-mediated GVHD from NK cell-mediated graft-versus-leukemia. Further research is warranted to explore other modalities of COSBL, determine the optimal dosing and combinations for COSBL, and identify predictive biomarkers for patient stratification, ultimately paving the way for improved outcomes in hematopoietic cell transplantation recipients.
Examining the contribution of an underutilized food source, Bambara Groundnut, in improving protein intake in Sub-Saharan Africa
Authors: Veldsman Zani , Pretorius Beulah , Schönfeldt Hettie Carina 
Published: August 2023

IntroductionBambara groundnut (BGN) is an underutilised, indigenous crop in sub-Saharan Africa. As an underutilised crop the nutritional contribution it can make is not well researched and documented. This study aims to better understand the nutritional profile and protein quality of BGN and the potential of this legume to combat food and nutritional security in rural and malnourished communities.MethodsNutritional analysis, including proximate analysis, minerals, total fat and amino acid profile of BGN from three different regions in the Mpumalanga (MP) province of South Africa (SA), were determined. The protein quality was evaluated with various methods including CSEAA, IEAA, PDCAAS and DIAAS and compared with other pulses and legumes in the diet.ResultsBGN consists of - 18,9% carbohydrates, 9,4% protein and 3% fat as consumed. The protein quality is lower than some other commonly consumed pulses but can still be valuable as a complementary protein in the current traditional diet of the region.DiscussionThere is the potential that BGN, together with other commonly consumed plant-based foods (e.g. maize) form a complete protein, that can contribute to protein intake and alleviate the burden of protein-energy malnutrition, specifically in developing countries.
Correlation between [68Ga]Ga-FAPI-46 PET Imaging and HIF-1α Immunohistochemical Analysis in Cervical Cancer: Proof-of-Concept
Authors: Mokoala Kgomotso M. G. , Lawal Ismaheel O. , Maserumule Letjie C. , Bida Meshack , Maes Alex , Ndlovu Honest , Reed Janet , Mahapane Johncy , Davis Cindy , Van de Wiele Christophe , Popoola Gbenga , Giesel Frederik L. , Vorster Mariza , Sathekge Mike M. 
Published: August 2023

Hypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor in the physiological response to hypoxia is hypoxia-inducible factor-1alpha (HIF-1α). [68Ga]Ga-FAPI PET imaging has been demonstrated in various cancer types. We hypothesized that [68Ga]Ga-FAPI PET may be used as an indirect tracer for mapping hypoxia by correlating the image findings to pathological analysis of HIF-1α expression. The [68Ga]Ga-FAPI PET/CT scans of women with cancer of the cervix were reviewed and the maximum and mean standardized uptake value (SUVmax and SUVmean) and FAPI tumor volume (FAPI-TV) were documented. Correlation analysis was performed between PET-derived parameters and immunohistochemical staining as well as between PET-derived parameters and the presence of metastasis. Ten women were included. All patients demonstrated tracer uptake in the primary site or region of the primary. All patients had lymph node metastases while only six patients had distant visceral or skeletal metastases. The mean SUVmax, SUVmean, and FAPI-TV was 18.89, 6.88, and 195.66 cm3, respectively. The average FAPI-TV for patients with additional sites of metastases was higher than those without. Immunohistochemistry revealed varying intensities of HIF-1α expression in all tested samples. There was a positive correlation between the presence of skeletal metastases and staining for HIF-1α (r=0.80;p=0.017). The presence of skeletal metastasis was correlated to the HIF-1⍺ staining (percentage distribution). Furthermore, the FAPI-TV was a better predictor of metastatic disease than the SUVmax.
Qualitative Analysis for Solving a Fractional Integro-Differential Equation of Hyperbolic Type with Numerical Treatment Using the Lerch Matrix Collocation Method
Authors: Alsulaiman Raniyah E. , Abdou Mohamed A. , ElBorai Mahmoud M. , El-Sayed Wagdy G. , Youssef Eslam M. , Taha Mai 
Published: August 2023

In this research, we present a qualitative analysis for studying a new modification of a nonlinear hyperbolic fractional integro-differential equation (NHFIDEq) in dual Banach space CEE, J. Under some suitable conditions, the existence and uniqueness of a solution are demonstrated with the use of fixed-point theorems. The verification of the offered method has been conducted by applying the Lerch matrix collocation (LMC) method as a numerical treatment. The major motivation for selecting the LMC approach is that it reduces the solution of the given NHFIDEq to a matrix representation form corresponding to a linear system of algebraic equations; additionally, to demonstrate that the proposed strategy has better precision than alternative numerical methods, we study the error and the convergence analysis. Finally, we introduce numerical examples illustrating comparisons between the exact solutions and numerical solutions for different values of the Lerch parameters λ and time t as well as how the absolute error in each example is calculated.
Helichrysum stoechas (L.) Moench Inflorescence Extract for Tomato Disease Management
Authors: Sánchez-Hernández Eva , Álvarez-Martínez Javier , González-García Vicente , Casanova-Gascón José , Martín-Gil Jesús , Martín-Ramos Pablo 
Published: August 2023

Helichrysum stoechas is a singular halophyte that has been shown to have anti-inflammatory, antioxidant, and allelopathic properties. In the work presented herein, we have characterized its inflorescences hydromethanolic extract and assessed its antifungal activity for the pre- and postharvest management of tomato crop diseases. Gas chromatography–mass spectrometry characterization of the extract showed that 4-ethenyl-1,3-benzenediol, 2,3-dihydro-benzofuran, quinic acid, 3,5-dihydroxy-6,7,8-trimethoxy-2-phenyl-4H-1-benzopyran-4-one, 1,6-anhydro-β-D-glucopyranose, catechol, scopoletin, and maltol were the main constituents. The co-occurrence of pyranones, benzenediols, and quinic acids as phytoconstituents of H. stoechas extract resulted in promising in vitro minimum inhibitory concentrations of 500, 375, 500, 187.5, 187.5, and 375 μg·mL−1 against mycelia of Alternaria alternata, Colletotrichum coccodes, Fusarium oxysporum f. sp. lycopersici, Rhizoctonia solani, Sclerotinia sclerotiorum, and Verticillium dahliae, respectively. Further, to assess the potential of H. stoechas inflorescence extract for postharvest tomato crop protection, ex situ tests were conducted against C. coccodes, obtaining high protection at a dose of 750 μg·mL−1. Taking into consideration that the demonstrated activity is among the highest reported to date for plant extracts and comparable to that of the synthetic fungicides tested as positive controls, H. stoechas inflorescence extract may be put forward as a promising biorational and may deserve further testing in field-scale studies.
TT Genotype of TLR4 rs1928295 Is a Risk Factor of Overweight/Obesity in Han Chinese Children Aged 7–12 Years and Can Interact with Dietary Patterns to Affect the Incidence of Central Obesity and Lipid Profile, Systolic Blood Pressure Levels
Authors: Zhu Qi , Qian Ben , Xue Kun , Guo Hongwei , Liang Rui , Wu Jinlong , Wu Qisu , Zhou Geyi 
Published: August 2023

Previous studies have found that TLR4 rs1928295 polymorphism is associated with Body Mass Index in European and American Indian adults. This study evaluates the relationship between this locus polymorphism, obesity-related parameters and dietary patterns in Chinese Han Children. A total of 798 children aged 7–12 years were included in this cross-sectional study. An improved Multiple Ligase Detection Reaction was used for genotyping. Dietary patterns were identified by principal component factor analysis. The overweight/obesity rate of the TT genotype was greater than those of the CC/CT genotype (p = 0.032 and 0.048 in boys and girls, respectively). Boys of the TT genotype could interact with protein and cholesterol intake to increase low density lipoprotein (LDL) levels (p = 0.02, 0.015, respectively), while girls of the TT genotype could interact with total energy intake to increase triglyceride (TG) (p = 0.018) levels. Boys predisposed to a healthy balance dietary pattern (HBDP) and girls predisposed to an egg/fruit/fish dietary pattern (EFDP) were significantly associated with lower rates of central obesity (p = 0.045, 0.028). Boys carrying the TT genotype and predisposed to animal food dietary pattern (AFDP) had a higher level of low-density lipoprotein (p = 0.017) and systolic pressure (p = 0.044). Our results indicated that the TT genotype of TLR4 rs1928295 is a potential risk factor for obesity in Chinese Han children and is associated with dietary patterns.
Analisis Rendahnya Pemahaman Matematis Siswa Ditinjau dari Self Regulated Learning Pada Masa Pandemi Covid-19
Authors: Marlina Mira , Junedi Beni , Kiawati Elga Sandi , Setianti Selda 
Published: August 2023

Pemahaman materi menentukan keberhasilan siswa dalam belajar. Keberhasilan siswa belajar tergantung kepada kesadaran dan kemandirian siswa akan pentingnya belajar. Faktanya di sekolah kesadaran siswa terhadap proses belajarnya sendiri masih tergolong rendah. Rendahnya tingkat pemahaman siswa terhadap suatu mata pelajaran disebabkan karena regulasi diri siswa dalam kemandirian belajar belum optimal. Penelitian ini bertujuan untuk mengetahui penyebab rendahnya pemahaman konsep matematis siswa ditinjau dari self-regulated learning masa pandemi covid-19 di SMK Negeri 1 Kota Serang. Metode yang digunakan pada penelitian ini adalah metode kuantitatif-deskriptif cross section. Adapun sampel yang dipilih dari kelas X dan XI berjumlah 83 partisipan. Alat ukur yang digunakan yaitu kuesioner self-regulated learning dan soal tes pemahaman konsep matematis. Data di analisis menggunakan uji regresi linier berganda dan uji bivariat. Hasil penelitian menemukan bahwa self regulation learning siswa secara simultan berpengaruh signifikan terhadap pemahaman konsep matematis siswa. Indikator motivasi dan perilaku diketahui memiliki kontribusi yang signifikan, sedangkan metakognitif tidak berkontribusi terhadap pemahaman konsep matematis siswa.
Correspondencia inédita de José Mª Lacoizqueta
Authors: Goicoechea Marcaida Ángel 
Published: August 2023

El trabajo trata de mostrar una faceta poco conocida, hasta este momento, de la obra del botánico José María de Lacoizqueta: su relación epistolar con otros botánicos, entre ellos Miguel Colmeiro y Blas Lázaro e Ibiza, así como con el vascólogo Arturo Campión, explicándonos algunos aspectos de la génesis y redacción de su Diccionario de los nombres euskaros de las plantas (Pamplona, 1888).
Por otro lado, gracias a estas cartas, sabemos más de la aportación de Lacoizqueta a la onomástica botánica en euskera que figura en la obra de Colmeiro.
PERSEPSI MASYARAKAT TERHADAP MASA DEPAN PEKERJAAN REMAJA PUTUS SEKOLAH DI KENAGARIAN SUNGAI BETUNG KABUPATEN SIJUNJUNG
Authors: Zuwirda Zuwirda , Warman Adiya , Maiseptian Fadil 
Published: August 2023

Idealnya remaja harapan bangsa memiliki ilmu pengetahuan dan pekerjaan, tapi kenyataannya banyak dari mereka yang belum memiliki pekerjaan dan masih banyak yang hanya berhuru- hara bersama teman-temannya. Penelitian ini bertujuan untuk mengetahui pengetahuan dan pemahaman, penilaian, dan tindakan masyarakat terhadap masa depan pekerjaan remaja putus sekolah di Kenagarian Sungai Betung. Metode penelitian ini adalah metode kualitatif, dengan jenis deskriptif yaitu menggambarkan keadaan yang terjadi di lapangan apa adanya. Sumber data yaitu masyarakat yang berusia 40-50 tahun. Dengan menggunakan teknik purposive sampling, sabjek penelitian ini berjumlah 13 orang. Teknik pengumpulan data yang digunakan, yaitu: observasi dan wawancara. Hasil penelitian menunjukkan bahwa: (1) Pengetahuan dan pemahaman masyarakat tentang masa depan pekerjaan remaja putus sekolah, yaitu: (a) sebagian besar masyarakat berpendapat bahwa pendidikan dan pekerjaan itu penting; (b) sebagaian kecil berpendapat akan sulit bagi remaja untuk memperoleh pekerjaan yang baik dan memadai. (2) Penilaian masyarakat tentang masa depan pekerjaan remaja putus sekolah, yaitu: (a) pada umumnya masyarakat menilai bahwa tidak baik bagi remaja jika tidak berpendidikan dan memiliki keterampilan; (b) akan menyulitkan bagi remaja putus sekolah untuk mendapatkan pekerjaan. (3) Tindakan masyarakat tentang masa depan pekerjaan remaja putus sekolah, yaitu: (a) masyarakat membawa anak remajanya untuk ikut membantu bertani; (b) ikut mengurus dagangan orang tuanya yang memilki dagangan; (c) menyuruh remajanya untuk membuka usaha dengan modal yang telah disediakan; (d) masyarakat yang berperan sebagai Niniak Mamak, Tungku Tigo Sajarangan, Alim Ulama, dan Wali Nagari sering mengikut sertakan remaja putus sekolah untuk ikut kegiatan Kenagarian sesuai kemampuannya.
POTRET PENDIDIKAN NILAI DILEMBAGA PENDIDIKAN ISLAM
Authors: Fauzi Ahmad Nur , Nursikin Mukh. 
Published: August 2023

Tujuan dari penelitian ini adalah untuk menganalisis pentingnya nilai-nilai aqidah, akhlak, dan ibadah dalam pendidikan Islam di Indonesia serta tantangan yang dihadapi dalam mengajarkan nilai-nilai agama secara komprehensif. Selain itu, penelitian ini bertujuan untuk memahami peran lembaga pendidikan Islam, seperti madrasah, dalam membentuk karakter dan perilaku peserta didik agar menjadi individu yang utuh dan berakhlak mulia. Di Indonesia, pendidikan Islam menghadapi tantangan untuk mengajarkan siswa tentang nilai-nilai agama secara komprehensif. Pendidikan Islam diselenggarakan oleh organisasi yang dikenal dengan lembaga pendidikan Islam. Jenis-jenis lembaga pendidikan Islam antara lain pendidikan untuk keluarga, masjid, sekolah Islam, madrasah, pondok pesantren, dan perguruan tinggi. Pendidikan Islam sangat bergantung pada keluarga untuk menanamkan nilai-nilai agama pada anak. Sebagai lembaga pendidikan formal, madrasah juga berperan penting dalam memberikan pendidikan agama dan umum kepada siswa. Artikel Untuk menghasilkan individu yang berakhlak mulia, prinsip-prinsip agama harus diterapkan dalam kehidupan sehari-hari. Dengan penelitian ini, diharapkan dapat diperoleh pemahaman yang mendalam tentang pendidikan nilai-nilai aqidah, akhlak, dan ibadah dalam konteks pendidikan Islam di Lembaga Pendidikan Islam di Indonesia serta solusi yang relevan untuk meningkatkan pendidikan nilai-nilai Islam secara komprehensif. Penelitian ini menganut metode penelitian kepustakaan yaitu menyusun buku, jurnal, dan temuan penelitian terdahulu yang masih relevan dengan tema penulisan. Fokus pembahasan dilakukan secara deskriptif tentang Pendidikan nilai di lembaga pendidikan Islam yang di dalamnya terdiri dari beberapa lembaga, yakni keluarga, masjid, sekolah Islam, madrasah, pondok pesantren, dan perguruan tinggi.