bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow injection chemiluminescence determination of acetochlor and cartap‐HCl in freshwater samples using an acidic KMnO4–rhodamine‐B reaction system
Authors: Nisa Khair Un , Kakar Attiq Ur Rehman , Asghar Muhammad , Samiullah  , Naqeebullah  , Niamatullah  , Shah Arif 
Published: March 2023

AbstractA flow injection (FI) methodology using the acidic potassium permanganate (KMnO4)–rhodamine‐B (Rh‐B) reaction with chemiluminescence (CL) detection was established to determine acetochlor and cartap‐HCl pesticides in freshwater samples. Experimental parameters were optimized, and Chelex‐100 cationic exchanger mini column and solid‐phase extraction (SPE) were used as phase separation techniques. Linear calibration curves were observed for the standard solutions of acetochlor and cartap‐HCl over the ranges 0.005–2.0 mg L−1 [y = 1155.8x + 57.551, R2 = 0.9999 (n = 8)] and 0.005–1.0 mg L−1 [y = 979.76x + 14.491, R2 = 0.9998 (n = 8)] with LODs and LOQs of 7.5 × 10−4 and 8.0 × 10−4 mg L−1 (3σ blank) and 2.5 × 10−3 and 2.7 × 10−3 mg L−1 (10σ blank), respectively, with an injection throughput of 140 h−1. These methods were used to estimate acetochlor and cartap‐HCl with or without the SPE procedure, respectively, in spiked freshwater samples. Results obtained were not significantly different at a 95% confidence level to those of other reported methods. Recoveries for acetochlor and cartap‐HCl were obtained over the ranges 93–112% (RSD = 1.9–3.6%) and 98–109% (RSD = 1.7–3.8%), respectively. The most probable CL reaction mechanism was explored.
Cow's milk and hen's egg anaphylaxis: A comprehensive data analysis from the European Anaphylaxis Registry
Authors: Cichocka‐Jarosz Ewa , Dölle‐Bierke Sabine , Jedynak‐Wąsowicz Urszula , Sabouraud‐Leclerc Dominique , Köhli Alice , Lange Lars , Papadopoulos Nikolaos G. , Hourihane Jonathan , Nemat Katja , Scherer Hofmeier Kathrin , Hompes Stephanie , Ott Hagen , Lopes de Oliveira Lucila , Spindler Thomas , Vogelberg Christian , Worm Margitta 
Published: March 2023

AbstractBackgroundCow's milk (CM) and hen's egg (HE) are leading triggers of anaphylaxis in early childhood. The aim of this study was to identify clinical phenotypes and therapeutic measures for CM anaphylaxis (CMA) compared to HE anaphylaxis (HEA) in children up to 12 years of age, based on a large pan‐European dataset from the European Anaphylaxis Registry.MethodsData from 2007 to 2020 on clinical phenotypes and treatment from 10 European countries, as well as Brazil, were analysed. The two‐step cluster analysis was used to identify the most frequent phenotypes. For each trigger, three clusters were extracted based on sex, age, and existence of symptoms in four vitally important systems.ResultsAltogether 284 children with CMA and 200 children with HEA were identified. They were characterised as male (69% vs. 64%), infants (65% vs. 61%), with a most frequent grade III of Ring&Messmer classification (62% vs. 64%), in CMA versus HEA, respectively. Respiratory symptoms occurred more often in CMA (91% vs. 83%, p = 0.010), especially in infants (89% vs. 79%, p = 0.008). Cardiovascular symptoms were less frequent in CMA (30% vs. 44%, p = 0.002), in both infants (33% vs. 46%, p = 0.027), and older children (25% vs. 42%, p = 0.021). The clusters extracted in the CMA group were characterised as: (1) mild dermal infants with severe GI (40%), 2. severe dermal (35%), 3. respiratory (25%). While in HEA group: 1. infants with severe GI and/or reduction of alertness (40%), (2) conjunctival (16%), (3) mild GI without conjunctivitis (44%). The severity of the reaction was independent from the amount of ingested allergen protein, regardless of trigger. The first‐line adrenaline application differed between the countries (0%–92%, as well as the reasons for not administering adrenaline, p < 0.001).ConclusionsDespite the similarity of their age, sex, and severity grade, the clinical profiles differed between the CMA and HEA children. Adrenaline was underused, and its administration was country dependent. Further studies are needed to assess to what extent the differences in the clinical profiles are related to matrix and/or absorption effects, and/or the allergen itself.
Fluid‐structure interaction analysis of transcatheter aortic valve implantation
Authors: Fumagalli Ivan , Polidori Rebecca , Renzi Francesca , Fusini Laura , Quarteroni Alfio , Pontone Gianluca , Vergara Christian 
Published: March 2023

AbstractTranscatheter aortic valve implantation (TAVI) is a minimally invasive intervention for the treatment of severe aortic valve stenosis. The main cause of failure is the structural deterioration of the implanted prosthetic leaflets, possibly inducing a valvular re‐stenosis 5–10 years after the implantation. Based solely on pre‐implantation data, the aim of this work is to identify fluid‐dynamics and structural indices that may predict the possible valvular deterioration, in order to assist the clinicians in the decision‐making phase and in the intervention design. Patient‐specific, pre‐implantation geometries of the aortic root, the ascending aorta, and the native valvular calcifications were reconstructed from computed tomography images. The stent of the prosthesis was modeled as a hollow cylinder and virtually implanted in the reconstructed domain. The fluid‐structure interaction between the blood flow, the stent, and the residual native tissue surrounding the prosthesis was simulated by a computational solver with suitable boundary conditions. Hemodynamical and structural indicators were analyzed for five different patients that underwent TAVI – three with prosthetic valve degeneration and two without degeneration – and the comparison of the results showed a correlation between the leaflets' structural degeneration and the wall shear stress distribution on the proximal aortic wall. This investigation represents a first step towards computational predictive analysis of TAVI degeneration, based on pre‐implantation data and without requiring additional peri‐operative or follow‐up information. Indeed, being able to identify patients more likely to experience degeneration after TAVI may help to schedule a patient‐specific timing of follow‐up.
Triarylamines as Catholytes in Aqueous Organic Redox Flow Batteries
Authors: Farag Nadia L. , Jethwa Rajesh B. , Beardmore Alice E. , Insinna Teresa , O'Keefe Christopher A. , Klusener Peter A. A. , Grey Clare P. , Wright Dominic S. 
Published: March 2023

AbstractA series of triarylamines was synthesised and screened for their suitability as catholytes in redox flow batteries using cyclic voltammetry (CV). Tris(4‐aminophenyl)amine was found to be the strongest candidate. Solubility and initial electrochemical performance were promising; however, polymerisation was observed during electrochemical cycling leading to rapid capacity fade prescribed to a loss of accessible active material and the limitation of ion transport processes within the cell. A mixed electrolyte system of H3PO4 and HCl was found to inhibit polymerisation producing oligomers that consumed less active material reducing rates of degradation in the redox flow battery. Under these conditions Coulombic efficiency improved by over 4 %, the maximum number of cycles more than quadrupled and an additional theoretical capacity of 20 % was accessed. This paper is, to our knowledge, the first example of triarylamines as catholytes in all‐aqueous redox flow batteries and emphasises the impact supporting electrolytes can have on electrochemical performance.
Long‐term relationships between seed bank communities and wildfire across four North American desert sites
Authors: Hosna Rachel K. , Reed Sasha C. , Faist Akasha M. 
Published: March 2023

AbstractIt is well documented that the recovery of dryland plant communities following wildfire can be variable, and that legacies of fire can have long‐lasting effects on aboveground plant communities. However, our understanding of the degree to which dryland soil seed banks, or the viable seeds in situ, are impacted by fire and their subsequent postfire succession remains extremely poor. To address this important knowledge gap, we used a time‐since‐fire approach to investigate soil seed bank community changes approximately 15 and 30 years after wildfire and to determine the influence of microsites (e.g., shrub vs. interspace) on seed bank composition. We assessed soil seed bank metrics across four North American deserts, including two cold desert sites (Colorado Plateau and Great Basin) and two warm desert sites (Chihuahuan and Sonoran). In greenhouse emergence trials, we found that seed bank characteristics diverged between warm and cold desert sites, such that warm desert sites had seed banks dominated by annual plants while our cold desert sites had seed banks with greater proportions of perennial species, regardless of fire history. In cold desert sites, fire significantly altered seed bank species composition even 30 years after fire. Shrub versus interspace microsites had no observed influence on seed bank composition in any desert. However, seed bank species richness was greater under shrubs in both warm deserts. Non‐native species were present in the seed banks of all deserts and some were particularly abundant in the burned sites. Despite the presence of native species in both burned and unburned seed banks, the presence of non‐native species suggests some degree of vulnerability to future disturbances because fire can create amplifying feedback with many non‐native plants. Our results highlight strong differences in fires' relationship with seed banks for warm and cold desert sites and lend insight into how fire relates to the composition and diversity of the seeds that play a fundamental role in future plant communities.
Amphibian abundance is associated with reduced mosquito presence in human‐modified landscapes
Authors: Perrin Antoine , Pellet Jérôme , Bergonzoli Ludovic , Christe Philippe , Glaizot Olivier 
Published: March 2023

AbstractThe impacts of landscape anthropization on mosquito abundance and diversity are already well studied, but the underlying ecological factors behind these effects are still poorly understood. One such underlying ecological factor may be related to the loss of amphibians in human‐modified landscapes, providing ideal habitats for several mosquito species. In this study, we conducted a mosquito and amphibian larvae survey in 77 ponds along a gradient of landscape anthropization in western Switzerland. We used structural equation models to investigate the direct and indirect effects of building footprints and several local pond parameters on mosquito abundance and composition through amphibian abundance. We highlighted that landscape anthropization increases the presence probability of mosquito larvae and the proportion of Culex pipiens in mosquito communities. Our results also suggested that one of the ecological mechanisms underlying these effects is a reduction in amphibian abundance, limiting competition and predation experienced by mosquitoes in human‐modified landscapes. In addition, we showed that several local pond characteristics prevent the presence and abundance of mosquito larvae. Indeed, deep ponds, which promote amphibian abundance, limit the probability of larval mosquito presence, and large and old ponds have a lower larval mosquito abundance. Amphibians appear to be effective control agents of natural mosquito populations. Therefore, the development of measures to protect amphibians in human‐modified landscapes could help to reduce both mosquito‐related nuisances and the risk of emergence of vector‐borne diseases in humans and wildlife.
Global change risks a threatened species due to alteration of predator–prey dynamics
Authors: Labadie Guillemette , Hardy Clément , Boulanger Yan , Vanlandeghem Virginie , Hebblewhite Mark , Fortin Daniel 
Published: March 2023

AbstractAlthough global change can reshape ecosystems by triggering cascading effects on food webs, indirect interactions remain largely overlooked. Climate‐ and land‐use‐induced changes in landscape cause shifts in vegetation composition, which affect entire food webs. We used simulations of forest dynamics and movements of interacting species, parameterized by empirical observations, to predict the outcomes of global change on a large‐mammal food web in the boreal forest. We demonstrate that climate‐ and land‐use‐induced changes in forest landscapes exacerbate asymmetrical apparent competition between moose and threatened caribou populations through wolf predation. Although increased prey mortalities came from both behavioral and numerical responses, indirect effects from numerical responses had an overwhelming effect. The increase in caribou mortalities was exacerbated by the cumulating effects of land use over the short term and climate change impacts over the long term, with higher impact of land use. Indirect trophic interactions will be key to understanding community dynamics under global change.
Systematic review of sodium‐glucose cotransporter 2 inhibitors: a hopeful prospect in tackling heart failure‐related events
Authors: Aziri Buena , Begic Edin , Jankovic Slobodan , Mladenovic Zorica , Stanetic Bojan , Kovacevic‐Preradovic Tamara , Iglica Amer , Mujakovic Aida 
Published: March 2023

AbstractIn modern cardiology, sodium‐glucose cotransporter 2 (SGLT2) inhibitors are critical components of heart failure (HF) treatment algorithms and exert their effects primarily by preventing glucose reabsorption and facilitating its urinary excretion. The objective was to systematically review randomized controlled trials (RCTs) assessing the effects of SGLT2 inhibitors, particularly canagliflozin, empagliflozin, dapagliflozin, ertugliflozin, sotagliflozin (dual SGLT inhibitor), and their use in HF. Systematic searches of PubMed/Medline, The Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases were performed. There were no restrictions imposed on the date and status of publication; however, there were restrictions on language for the searched studies. A total of 1139 records were identified in the bibliographic searches from both databases and the register of choice for this systematic review. Following duplicate removal, screening for titles and abstracts, and thorough assessment of full‐text articles, 12 RCTs met the inclusion criteria. Altogether, 83 878 patients were included in this review. Among the included studies, two RCTs, with six respective reports, investigated canagliflozin, four RCTs with 13 derived reports investigated dapagliflozin, three RCTs with 12 separate reports studied the effects of empagliflozin, one RCT and its three respective reports assessed ertugliflozin's effects, and two RCTs with one added report investigated the dual inhibitor sotagliflozin. Pooled meta‐analytic effects of SGLT2 inhibitors were as follows: on atrial fibrillation odds ratio (OR) = 0.83, 95% confidence interval (CI): 0.68–1.01, prediction interval (PI): 0.57–1.19; on HF hospitalization OR = 0.69, 95% CI: 0.60–0.78, PI: 0.60–0.78; on cardiovascular death OR = 0.82, 95% CI: 0.58–1.15, PI: 0.42–1.60; and on major adverse cardiovascular events OR = 0.90, 95% CI: 0.77–1.06, PI: 0.71–1.15. SGLT2 inhibitors significantly improve the quality of life in HF patients. Their beneficial effects on HF, especially in left ventricular dysfunction, have made their use possible irrespective of diabetes mellitus or atrial fibrillation status.
Proteomics analysis of human breast milk by two‐dimensional polyacrylamide gel electrophoresis (2D‐PAGE) coupled with mass spectrometry to assess breast cancer risk
Authors: Aslebagh Roshanak , Whitham Danielle , Channaveerappa Devika , Lowe James , Pentecost Brian T. , Arcaro Kathleen F. , Darie Costel C. 
Published: March 2023

AbstractBreast cancer (BC) is one of the most common cancers and one of the most common causes for cancer‐related mortality. Discovery of protein biomarkers associated with cancer is considered important for early diagnosis and prediction of the cancer risk. Protein biomarkers could be investigated by large‐scale protein investigation or proteomics, using mass spectrometry (MS)‐based techniques. Our group applies MS‐based proteomics to study the protein pattern in human breast milk from women with BC and controls and investigates the alterations and dysregulations of breast milk proteins in comparison pairs of BC versus control. These dysregulated proteins might be considered potential future biomarkers of BC. Identification of potential biomarkers in breast milk may benefit young women without BC, but who could collect the milk for future assessment of BC risk. Previously we identified several dysregulated proteins in different sets of human breast milk samples from BC patients and controls using gel‐based protein separation coupled with MS. Here, we performed 2D‐PAGE coupled with nano‐liquid chromatography–tandem MS (nanoLC‐MS/MS) in a small‐scale study on a set of six human breast milk pairs (three BC samples vs. three controls) and we identified several dysregulated proteins that have potential roles in cancer progression and might be considered potential BC biomarkers in the future.
Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals
Authors: Gao Yuan , Zong Zihao , Xia Wei , Fang Xiangjun , Liu Ruiling , Wu Weijie , Mu Honglei , Han Yanchao , Xiao Shangyue , Gao Haiyan , Chen Hangjun 
Published: March 2023

AbstractIn this study, the hepatoprotective effect of alkali extract (NE) of water bamboo shoot (WBS) against acute alcoholic liver injury (ALI) in mice was evaluated, and its underlying mechanisms were explored. Animal experiment demonstrated that NE exhibited hepatoprotective effect on alcoholic intake‐induced ALI via significantly enhancing the hepatic activities of alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and catalase (CAT), whereas significantly attenuated hepatic levels of malondialdehyde (MDA), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α). The potential molecular mechanism and bioactive compounds of NE against ALI were explored by bioinformatics analysis and isosinensetin was found to be the major bioactive compounds in NE against ALI. The western blot analysis showed that NE inhibited phosphorylation of p65 and IκBα to suppress the NF‐κB pathway. Overall our result indicated that WBS possesses potential hepatoprotective effects against ALI.
Uncharted risk measures for the management of sustainable mining
Authors: Watts Beatriz A. , Palmeira Zago Valéria C. , Gopakumar Lakshmi , Ghazaryan Karen , Movsesyan Hasmik 
Published: March 2023

Abstract
Governments commit to ensuring the welfare of their citizens by drafting and enforcing regulations that ultimately ensure the sustainability of mining. This study contributes to improving the sustainability of mining throughout the mine's lifecycle until the final destination of the mining products. We propose recommendations that address the sustainability of mining from a global perspective, framed around the United Nations Sustainable Development Goals (SDGs), following waste hierarchy with Common Agricultural Policies, and policies from the Green Deal on climate, energy, transport, and taxation. Tailings are the most significant source of environmental impact in mining operations and, therefore, must comply with controlling regulations through Tailings Management Facilities (TMFs). However, there have been several mining accidents involving TMFs worldwide. The recommendations begin during planning, preconstruction, and construction with practices such as fair consultations, tax revenue fairness, and mandatory insurance. The operation and management support parallel industries to mining and supporting health and education. Emergency planning involves the surrounding communities in mock drills and environmental monitoring. In the closure and rehabilitation, remediation technologies such as phytoremediation, carbon sequestration incentives, and biomass valorization are recommended. Finally, supporting a circular economy by prioritizing ethical consumption, resource reduction, material recovery, and replacing toxic minerals and materials from the start with “benign by design” is recommended. The strategies involve stakeholders directly or indirectly related to the mining companies' contamination and demonstrate a commitment to the SDGs, offering a holistic perspective on scientific, social, and regulatory issues. Integr Environ Assess Manag 2023;19:949–960. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Effect of a Three-Day Course of Dexamethasone on Acute Phase Response Following Treatment With Zoledronate: A Randomized Controlled Trial
Authors: Murdoch Rachel , Mellar Anna , Horne Anne M. , Billington Emma , Chan Pui Ling , Gamble Gregory D. , Reid Ian R. 
Published: March 2023

ABSTRACT
Zoledronate is a potent intravenous bisphosphonate effective in the management of osteoporosis, Paget's disease and skeletal-related events in malignancy. Its most frequent adverse effect is the acute phase response (APR), an inflammatory reaction characterized by fever, musculoskeletal pain, headache, and nausea. This randomized, placebo-controlled, double-blind study investigated the efficacy of a three-day course of dexamethasone 4 mg daily in reducing incidence of APR. Participants (n = 60) were randomized to receive either 4 mg of oral dexamethasone 1.5 hours before zoledronate and once a day for the following 2 days, or placebo. Oral temperature was measured at baseline and three times a day for the following 3 days, and questionnaires assessing symptoms of the APR were completed at baseline and for 3 days following zoledronate. Use of anti-inflammatory medication in the 3 days following zoledronate was recorded. The primary outcome was the temperature change from baseline. There was a significant difference in the primary outcome between the dexamethasone and placebo groups (p &lt; 0.0001), with a mean decrease in temperature of 0.10°C (95% confidence interval [CI], −0.34 to 0.14) in the dexamethasone group compared with a mean increase in temperature of 0.84°C (95% CI, 0.53–1.16) in the placebo group on the evening following zoledronate. There was also a difference in APR-related symptom score over time between the two groups (p = 0.0005), with a median change in symptom score in the dexamethasone group 1 day after zoledronate of 0 (95% CI, 0–1) compared with 3 (95% CI, 0–5) in the placebo group. An increase in temperature of ≥1°C to a temperature of &gt;37.5°C occurred in two of 30 (6.7%) participants in the dexamethasone group compared with 14 of 30 participants (46.7%) in the placebo group (p = 0.0005). This study demonstrates that a 3-day course of dexamethasone substantially reduces the APR following zoledronate infusion. © 2023 American Society for Bone and Mineral Research (ASBMR).