bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of acute normovolemic hemodilution during liver surgery: a Meta-analysis
Authors: Yang Ming , Liu Jinlong 
Published: June 2023

Abstract

Objective
The aim of this study was to evaluate the safety and efficacy of acute normovolemic hemodilution (ANH) during liver surgery.

Methods
Structured searches of the PubMed, Chinese Biological Medicine Database, and Cochrane Library electronic databases were performed, followed by a meta-analysis of outcomes, including intraoperative blood transfusion(s), intraoperative bleeding, postoperative hematocrit (Hct) levels, postoperative prothrombin time (PT), and number of patients who underwent transfusions during liver surgery.

Results
In total, 14 eligible studies were included in the meta-analysis, which revealed that ANH for liver resection was associated with a reduction in intraoperative blood transfusions [weighted mean difference (WMD) -1.99; 95% confidence interval (CI) -2.82 to -1.16; P < 0.00001]. The ANH group experienced less intraoperative bleeding (WMD -72.81; 95% CI -136.12 to -9.50; P < 0.00001) and exhibited a lower postoperative Hct level (WMD -3.38; 95% CI -7.14 to -0.67; P < 0.00001) than the control group. Moreover, meta-analysis revealed that postoperative prothrombin time was not affected by ANH (WMD -0.02; 95% CI -0.18 to -0.32; P = 0.65). Finally, the number of patients requiring allogeneic transfusion was significantly smaller in the ANH group than in the control group (odds ratio 0.13; 95% CI 0.09 to 0.18; P = 0.24).

Conclusion
Results of the present meta-analysis indicated that ANH can reduce intraoperative bleeding and the need for blood transfusions. In addition, ANH did not negatively affect the coagulation system after surgery; therefore, ANH appears to be safe and effective during liver surgery.
The expression of miR-155 and miR-181 in gastric cancer and their effects on clinical parameters and prognostic value*
Authors: Shi Zhenfeng , Lin Shuchun , Tang Xiaorong , Zheng Hongli , Wang Fei , Tao Wudong 
Published: June 2023

Abstract

Objective
The aim of this study was to investigate the expression and clinical significance of miR-155 and miR-181 in gastric cancer.

Methods
Sixty-eight patients with gastric cancer and 80 healthy volunteers were selected as subjects. Serum samples of patients and volunteers were collected to detect miR-155 and miR-181 expression levels in serum and tumor tissues.

Results
miR-155 and miR-181 serum levels were significantly higher in patients with gastric cancer than those in the control group (P < 0.05). miR-155 and miR-181 expression levels in gastric cancer tissues were 16.74 ± 4.29 and 12.17 ± 3.26, respectively and 3.42 ± 0.39) and 3.06 ± 0.69 in paracancerous tissues, respectively, and they were 1.22 ± 0.21 and 1.08 ± 0.35 in normal tissues, respectively. miR-155 and miR-181 expression levels in cancer tissues were significantly higher than adjacent tissues, and they were lowest in normal tissues (P < 0.05). High miR-155 and miR-181 expression had significant effects on differentiation, T stage, lymph node metastasis, and clinical stage (P < 0.05). Cox multivariate analysis showed that onset, T stage, clinical stage, differentiation degree, lymph node metastasis, miR-155, and miR-181 were independent risk factors for prognosis of patients with gastric cancer.

Conclusion
Serum miR-155 and miR-181 have a diagnostic value in gastric cancer, and they are strong signals of poor prognosis.
Experimental study on the relationship between traumatic stress and tumor growth, proliferation, and metastasis*
Authors: Cao Weigang , Qiu Baoan 
Published: June 2023

AbstractObjectiveThis study aimed to investigate the relationship between traumatic stress and tumor growth, proliferation, and metastasis.MethodsA scalding method was used as an injurious factor to induce traumatic stress in Wistar rats. The rats were randomly divided into three groups—the control group, mild-scald group, and severe-scald group, with 14 rats in each group. Wistar rats were used to subculture the Walker-256 cell line for the generation of tumor ascites. Tumor cells from the ascites were cultured and used to establish a rat subcutaneous xenograft model. After 7 days, the mild-burn group and the severe-burn group were subjected burns to 10% and 15% of their backs, respectively. Blood was taken from the tail vein of rats at different times to detect changes in blood cortisol, IL-1β, and TNF-α levels. Pathological specimens were collected 14 days later, and immunohistochemistry was performed to examine vascular endothelial growth factor (VEGF), proliferating cell nuclear antigen (PCNA), E-cadherin, and vimentin.ResultsCortisol, IL-1β and TNF-α levels were significantly higher in the scalding groups than in the control group. Tumor examination was performed after 14 days. The changes in tumor size showed that the tumor volume in the control group (0.593 ± 0.195 cm3) and the mild-scald group (0.782 ± 0.344 cm3) were not significantly different. However, the tumor volume was significantly larger in the severe-burn group (1.806 ± 0.838 cm3) than in the control and the mild-burn groups(P< 0.05). Tumor tissue immunohistochemistry showed that the percentage of cells expressing PCNA in the control group, mild-scald group, and severe-scald group was 57.1%, 71.4% and 85.7%, respectively, and the differences among the groups were statistically significant. The number of VEGF-positive cells in the mild- and severe-scald groups was significantly higher than those of the control group (P< 0.05). The number of E-cadherin-positive cells in the tumor tissues was significantly lower in the severe-scald group than that in the control and mild-scald groups. Vimentin showed the opposite trend in the tumor tissue, and the differences were statistically significant (P< 0.05).ConclusionDifferent degrees of a traumatic response in tissues caused by scalding can cause a corresponding stress response in the body. The release of inflammatory mediators; increase in VEGF, PCNA and vimentin in the tumor tissue; and decrease in E-cadherin lead to a change in tumor tissue growth and metastasis. Traumatic stress is associated with tumor growth, proliferation, and metastasis.
Benefit of adjuvant chemoradiotherapy in patients with pathologically lymph node-positive and locally advanced gastric cancer
Authors: Zhang Shanhui , Zhou Fei , Liang Donghai , Lv Hongying , Yu Hongsheng 
Published: June 2023

AbstractObjectiveThis study aimed to compare the effectiveness of adjuvant chemoradiotherapy (CRT) and adjuvant chemotherapy (ChT) for T3-4/N+ gastric cancer (GC) following D2/R0 dissection, and identify the specific subgroups that could benefit from adjuvant CRT.MethodsAll eligible patients were divided into the CRT group and ChT group. We assessed the survival outcomes and patterns of recurrence for each group, and determined the prognostic factors for survival by performing Cox proportional risk regression analyses.ResultsA total of 192 gastric cancer patients were included in the study. The estimated 3-year and 5-year disease-free survival (DFS) probabilities in the CRT and ChT groups were 52.9%vs.36.7% (P= 0.024) and 41.2%vs.31.1% (P= 0.148), respectively, and the estimated 3-year and 5-year overall survival (OS) probabilities were 82.4%vs.70.0% (P= 0.044) and 52.0%vs.35.6% (P= 0.022). Patients in the CRT group had a lower risk of locoregional recurrence than those in the ChT group (20.6%vs.34.4%;P= 0.031). The subset analyses revealed that patients with stage N1-2 disease were more likely to benefit from adjuvant CRT than from adjuvant ChT (DFS: 53.1%vs.36.4%;P= 0.039; OS: 53.1%vs.38.6%;P= 0.036).ConclusionFor locally advanced gastric cancer patients with LN+, adjuvant CRT showed superior survival benefits compared with adjuvant ChT alone. Patients with N1-2 achieved better survival from adjuvant CRT.
Correlation between clinicopathological parameters of lung adenocarcinoma and lymph node metastasis
Authors: Wang Shixun , Lin Gaoyang , Ge Nan , Yang Ronghua , Li Mengjun , Zhao Donghua , Li Peng , Wang Yongjie 
Published: June 2023

AbstractObjectiveThe aim of the study was to study the correlation between the clinicopathological parameters of lung adenocarcinoma and lymph node metastasis and identify the risk factors of lymph node metastasis.MethodsThe data of 258 patients with postoperative lung adenocarcinoma (mainly based on their pathological data) were collected and analyzed, and their basic information was counted.ResultsMaximum tumor diameter was found to be an independent risk factor for lymph node metastasis. The larger the maximum diameter of the tumor in patients with lung adenocarcinoma, the higher the likelihood of lymph node metastasis. Solid predominant adenocarcinoma with mucin production is as an independent risk factor for superior mediastinal and subcarinal lymph node metastasis. Primary adenocarcinomas in the lower lobe of the lung may have a higher rate of lymph node metastasis than those in the upper lobe.ConclusionThe known pathological subtypes of lung adenocarcinoma can be used for the prediction of lymph node metastasis in various regions and guide the dissection of lymph nodes that would improve patients' prognosis.
Device-Free Target Following with Deep Spatial and Temporal Structures of CSI
Authors: Chen Ching-Lan , Ko Chun-Hsien , Wu Sau-Hsuan , Tseng Heng-Shih , Chang Ronald Y. 
Published: June 2023

AbstractA novel device-free target tracking and following method is proposed based on both the received signal strength (RSS) and channel state information (CSI) of WiFi signals. Different from the typical device-free target tracking method, we consider a scenario where the device-free target under tracking is followed by a device that transmits the reference signals for location tracking of the target and the device itself. To meet the goal, a deep spatial-temporal neural network model is designed to learn and exploit the multi-resolution spatial and temporal features of RSSI and CSI for location tracking. By experimental results on our testbed, we show that the average positioning accuracy of the proposed method for the device-free target can reach 0.773 meters, which has a $$64\%$$

64
%

improvement over the accuracy of 2.164 meters of a typical device-free tracking method under the same experimental condition.
Neuroprotective and nephroprotective effects of Ircinia sponge in polycyclic aromatic hydrocarbons (PAHs) induced toxicity in animal model: a pharmacological and computational approach
Authors: Nabil-Adam Asmaa , Youssef Fadia S. , Ashour Mohamed L. , Shreadah Mohamed A. 
Published: June 2023

AbstractThe present study investigated the neuroprotective and nephroprotective effects of the sponge Ircinia sp. ethyl acetate extract (ISPE) against persistent aromatic pollutants in vitro and in vivo. Different exponential experimental assays were applied to this study. An in vitro study to investigate the potential therapeutic effect of ISPE using antioxidants (for example, ABTS and DPPH) and anti-Alzheimer assays (inhibition of acetylcholinesterase); the in-vivo study was designed to evaluate the protective effect of ISPE as neuroprotective and nephroprotective against the destructive effect of PAH. Several assays included oxidative assays (LPO), antioxidant biomarkers (GSH, GST), and inflammatory and neurodegenerative biomarkers (PTK,SAA). Additionally, the results were confirmed using histopathological examination. The in silico screening study improved the in vitro and in vivo findings through interaction between the aryl hydrocarbon receptor (AHR) and the polyphenolic content of ISPE extract, which was determined using LCMSM. The results and discussion showed that ISPE exhibited a promising antioxidant and anti-acetylcholinesterase activity as evidenced by IC50 values of 49.74, 28.25, and 0.18 µg/mL in DPPH, ABTS, and acetylcholinesterase inhibition assays, respectively. In vivo, the study showed that animals receiving ISPE before poly aromatic hydrocarbons administration PAHs (Prot, ISPE) showed significant amelioration in kidney functions manifested by the reduction of serum urea, uric acid, and creatinine by 40.6%, 66.4%, and 134.8%, respectively, concerning PAH-injected mice (HAA). Prot, ISPE revealed a decline in malondialdehyde (MDA) and total proteins (TP) in kidney and brain tissues by 73.63% and 50.21%, respectively, for MDA and 59.82% and 80.41%, respectively, for TP with respect to HAA. Prot, ISPE showed significant elevation in reduced glutathione (GSH) and glutathione transferase (GST) in kidney and brain tissues and reduction in the inflammatory and pre-cancerous biomarkers, namely, serum protein tyrosine kinases (PTKs) and serum amyloid A (SAA). These findings were further supported by histopathological examination of kidney and brain tissues, which revealed normal structure approaching normal control. Metabolic profiling of ISPE using LC–MS-MS showed the presence of fourteen polyphenolic compounds belonging mainly to phenolic acids and flavonoids. In silico study revealed that all the tested compounds exerted certain binding with the aryl hydrocarbon receptor, where rutin showed the best fitting (ΔG =  − 7.6 kcal/mol−1) with considerable pharmacokinetic and pharmacodynamic properties revealed from in silico ADME (Absorption, Distribution, Metabolism, and Excretion) study. Hence, it can be concluded that the Ircinia sponge showed a promising protective effect versus kidney and brain toxicity triggered by PAHs.
Graphical Abstract
Performance of regional water purification plants during extreme weather events: three case studies from New South Wales, Australia
Authors: Hickey Adrian , Senevirathna Lalantha 
Published: June 2023

Abstract
Climate change is altering weather patterns, which affects water supply systems globally. More frequent extreme weather events like floods, droughts, and heatwaves are impacting the availability of raw water sources that supply cities. These events can lead to less water, higher demand, and potential infrastructure damage. Water agencies and utilities must develop resilient and adaptable systems to withstand shocks and stresses. Case studies demonstrating the impact of extreme weather on water quality are important for developing resilient water supply systems. This paper documents the challenges faced by regional New South Wales (NSW) in managing water quality and supply during extreme weather events. Effective treatment processes, such as ozone treatment and adsorption, are used to maintain drinking water standards during extreme weather. Water-efficient alternatives are provided, and critical water networks are inspected to identify leaks and reduce system demand. Local government areas must collaborate and share resources to ensure that towns can cope with future extreme weather events. Systematic investigation is needed to understand system capacity and identify surplus resources to be shared when demand cannot be met. Pooling resources could benefit regional towns experiencing both floods and droughts. With expected population growth in the area, regional NSW councils will require a significant increase in water filtration infrastructure to handle increased system loading. Continuous research, regular strategy reviews, and innovative approaches are essential to ensure a secure and reliable water supply during future extreme weather events.
The Usefulness of Fine Needle Aspiration Cytology in the Management of Parotid Gland Masses at a Tertiary Academic Hospital
Authors: Mdletshe Fanelesibonge B , Luvhengo Thifhelimbilu E , Masege Dipuo 
Published: June 2023

Abstract
Background
Fine needle aspiration cytology (FNAC) is an integral part of the preoperative work-up of parotid tumours.

Aim
To determine the rate of concordance between FNAC and histology following parotidectomy.

Methods
A review of records of patients who had parotidectomy which was preceded FNAC was done. Data collected included patients’ demography, presenting symptoms and clinical signs; cytology and post-operative histology results.

Results
Seventy-seven records were found and 14 were excluded. Forty-five (71%: 45/63) of the tumours were benign, 21% (13/63) malignant and 8% (5/63) inflammatory lesions. Forty-one (91.1%: 41/45) of the benign tumours had concordance between FNAC and final histology. Seven (63.6%: 7/11) of FNAC diagnosed malignancies were confirmed on histology.

Conclusion
Around 71% of parotid masses were benign. Painful masses are more likely to be malignant and FNAC is more reliable for the diagnosis of pleomorphic adenoma than rare benign and malignant tumours of the parotid gland.
Narrative Persuasion – theoretische Ansätze und empirische Ergebnisse zur Überzeugungskraft von Narrationen
Authors: Sukalla Freya 
Published: June 2023

ZusammenfassungÜber die anschauliche Darstellung von Ereignissen und Figuren können Geschichten abstrakte Sachverhalte verständlich machen oder auch neue Perspektiven eröffnen. Indem sie Rezipierenden ermöglichen, kognitiv und emotional tief in die Welt einer Geschichte einzutauchen, können Narrationen ihre persuasive Wirkung entfalten. Das Forschungsfeld der narrativen Persuasion widmet sich der systematischen Untersuchung dieser Wirkung von Geschichten. Dieser Beitrag führt zunächst in die theoretischen Ansätze zur Erklärung der Persuasivität von Narrationen ein und stellt im Anschluss den empirischen Forschungsstand dar. Insgesamt bestätigen die Forschungsergebnisse die persuasive Wirkkraft von Geschichten auf Wissen, Einstellungen und Verhalten ihrer Rezipierenden. Es wurden jedoch auch verschiedene Faktoren identifiziert, die narrative Effekte einerseits verstärken, aber auch verhindern können. Dazu gehören z. B. die Erzählperspektive, die Voreinstellungen der Rezipierenden oder auch der Rezeptionskontext. Ausblickend werden ethische Aspekte und unerwünschte Effekte von Geschichten thematisiert.
Potential Applications of Silicate Solubilizing Bacteria and Potassium Silicate on Sugarcane Crop under Drought Condition
Authors: Anitha R. , Vanitha K. , Tamilselvi C. , Jeyakumar P. , Vijayalakshmi D. , Yuvaraj M. , Nageswari R. , Dhanushkodi V. , Cyriac Jaiby 
Published: June 2023

AbstractThe decline of soil nutrient status and productivity of crops, and restoration of soil health is a key global concern. Crop yields are reduced by soil degradation, which endangers the world's food supply. Crop yields and soil health are further decreased by improper fertilizers use in conjunction with intense cropping. A wide variety of plants, particularly monocotyledonous crops can collect significant levels of silicon in their organs showing the benefits of silicon in terms of growth, biomass, and yield, whereas most dicots are unable to accumulate enough Si under their epidermal system. In the present investigation, treatment of applying silica solubilizer at a rate of 12.5 kg with 50 kg FYM/ha in soil with sett treatment of 0.5% K2SiO3,2.5% urea and potash foliar spray in a specified time showed a significant result in all the growth and yield parameters tested when plant and its ratoon were in drought condition.
Development of Pyros Alloy as a Certified Reference Material for Thermal Expansion Coefficient Measurements
Authors: Bi Jingliang , Xiu Hongyu 
Published: June 2023

AbstractThe push-rod dilatometer is the most widely used and popular commercial apparatus for measuring the thermal expansion coefficient of metals, it should be metrological verified before testing. Certified reference materials are the most applicable and effective means of verifying such equipment. Here, a reference material [termed Pyros (Ni-based) alloy] was developed for measuring the thermal expansion coefficient. The Pyros alloy reference material exhibited a high thermal expansion coefficient: a range of 12.7–16.8 (× 10–6 °C−1). The maximum temperature of the certified value was 1000 °C. This range and value almost span the entire application needs of metals, especially steel alloy or superalloys. Thus, Pyros alloy is suitable as a reference material for validating the push-rod dilatometer based on comparative measurements.
The added value of (1,3)-β-D-glucan for the diagnosis of Invasive Candidiasis in ICU patients: a prospective cohort study
Authors: Christner Martin , Abdennadher Beya , Wichmann Dominic , Kluge Stefan , Pepić Amra , Aepfelbacher Martin , Rohde Holger , Olearo Flaminia 
Published: June 2023

Abstract
Purpose
Beta-D-Glucan (BDG) testing has been suggested to support the diagnosis of candidemia and invasive candidiasis. The actual benefit in critically ill high-risk patients in intensive care units (ICU) has not been verified so far.

Methods
In ICU patients receiving empirical echinocandin treatment for suspected invasive candidiasis (IC), serial BDG testing using the Fujifilm Wako Beta-Glucan Test was performed, starting on the first day of echinocandin administration and every 24-48 h afterwards. Diagnostic accuracy was determined for single testing and serial testing strategies using a range of cut-off values. In addition, we compared the added value of these testing strategies when their results were introduced as additional predictors into a multivariable logistic regression model controlling for established risk factors of IC.

Results
A total of 174 ICU patients, forty-six of which (25.7%) classified as cases of IC, were included in our study. Initial BDG testing showed moderate sensitivity (74%, 95%CI 59–86%) and poor specificity (45%, 95% CI 36–54%) for IC which could hardly be improved by follow-up testing. While raw BDG values or test results obtained with very high thresholds improved the predictive performance of our multivariable logistic regression model for IC, neither single nor serial testing with the manufacturer-proposed low-level cut-off showed substantial benefit.

Conclusions
In our study of critically ill intensive care patients at high risk for candidemia or invasive candidiasis, diagnostic accuracy of BDG testing was insufficient to inform treatment decisions. Improved classification was only achieved for cases with very high BDG values.
Mental health and lived experience: The value of lived experience expertise in global mental health
Authors: Sartor Claudia 
Published: June 2023

Abstract
There is no disputing the current established global consensus that people with lived experience of a mental health condition (“people with lived experience”) play an integral role in influencing policy and processes in global mental health. Specifically, the role they hold as agents of change through which they can lead and co-lead projects on mental health, alongside a multidisciplinary team, as recommended in the findings of the report of Lancet Commission on ending stigma and discrimination (Thornicroft et al. [2022], “The Lancet Commission on ending stigma and discrimination in mental health”, Lancet, 400, 1438–1480). Immense value is associated with their unique expertise not learned through theoretical concept but based on real-life experience. Appreciating their involvement in processes is a human right, supported by international human rights instruments such as the United Nations Convention on the Rights of Persons with Psychosocial Disabilities (2006). However, there remains an expectation that people with lived experience are expected to be involved in processes and service delivery without receiving remuneration for their expertise. This article will provide the basis for which processes must follow the principle of equity; that lived experience expertise ought to be equally compensated for based on equal pay for equal work. In closing, it will provide a recommendation for stakeholders on how to improve upon effective engagement with people with lived experience, leading to meaningful and authentic contributions.