bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sacubitril/valsartan improves all-cause mortality in heart failure patients with reduced ejection fraction and chronic kidney disease
Authors: Lee Wei-Chieh , Liao Ting-Wei , Chen Tien-Yu , Fang Hsiu-Yu , Fang Yen-Nan , Chen Huang-Chung , Lin Yu-Sheng , Chang Shang-Hung , Chen Mien-Cheng 
Published: January 2023

Abstract
Background
Impaired renal function is frequently observed in patients with heart failure and reduced ejection fraction (HFrEF). The differential effect of sacubitril/valsartan and angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers (ACEIs/ARBs) on the clinical and renal outcomes in patients with HFrEF and chronic kidney disease (CKD) remains unknown.

Aims
This study aimed to explore the differential effect of sacubitril/valsartan and ACEI/ARB on the clinical and renal outcomes as well as renal function over a 12-month follow-up period in HFrEF patients with and without CKD.

Methods
Patients with HfrEF (LVEF ≤35%) and NYHA class ≥II were enrolled from the Chang Gung Research Database between 2017 and 2020. Baseline characteristics were compared between patients prescribed sacubitril/valsartan and ACEI/ARB. After propensity score matching, the following clinical and renal outcomes were compared between the two groups in patients with and without CKD over a 12-month follow-up period: acute kidney injury (AKI), emergent dialysis/renal death, HF hospitalization, cardiovascular mortality, and all-cause mortality.

Results
This study enrolled 3735 HFrEF patients with a mean left ventricular EF of 27.56 ± 5.86%, who had been prescribed sacubitril/valsartan (N = 1708) or ACEI/ARB (N = 2027). After propensity score matching, the clinical and renal outcomes did not differ between the sacubitril/valsartan and ACEI/ARB groups in patients without CKD. In patients with CKD, the ACEI/ARB group had a significantly higher incidence of all-cause mortality than the sacubitril/valsartan group (14.89% vs. 10.50%; hazard ratio 1.46; 95% confidence interval 1.06–2.00; p = 0.02), and the incidence of AKI, HF hospitalization, and CV mortality did not differ between the two groups.

Conclusions
Sacubitril/valsartan had a lower all-cause mortality compared to ACEI/ARB in symptomatic HFrEF patients with CKD. Further prospective randomized studies are warranted to confirm our findings.
Research-ready data: the C-Surv data model
Authors: Bauermeister Sarah , Bauermeister Joshua R , Bridgman Ruth , Felici Caterina , Newbury Mark , North Laura , Orton Christopher , Squires Emma , Thompson Simon , Young Simon , Gallacher John E 
Published: January 2023

AbstractResearch-ready data (data curated to a defined standard) increase scientific opportunity and rigour by integrating the data environment. The development of research platforms has highlighted the value of research-ready data, particularly for multi-cohort analyses. Following stakeholder consultation, a standard data model (C-Surv) optimised for data discovery, was developed using data from 5 population and clinical cohort studies. The model uses a four-tier nested structure based on 18 data themes selected according to user behaviour or technology. Standard variable naming conventions are applied to uniquely identify variables within the context of longitudinal studies. The data model was used to develop a harmonised dataset for 11 cohorts. This dataset populated the Cohort Explorer data discovery tool for assessing the feasibility of an analysis prior to making a data access request. Data preparation times were compared between cohort specific data models and C-Surv.It was concluded that adopting a common data model as a data standard for the discovery and analysis of research cohort data offers multiple benefits.
Suicide and other causes of death among Chernobyl cleanup workers from Estonia, 1986 − 2020: an update
Authors: Rahu Kaja , Rahu Mati , Zeeb Hajo , Auvinen Anssi , Bromet Evelyn , Boice John D. 
Published: January 2023

AbstractMortality was studied in a cohort of 4831 men from Estonia who participated in the environmental cleanup of the radioactively contaminated areas around Chernobyl in 1986–1991. Their mortality in 1986–2020 was compared with the mortality in the Estonian male population. A total of 1503 deaths were registered among the 4812 traced men. The all-cause standardized mortality ratio (SMR) was 1.04 (95% CI 0.99–1.09). All-cancer mortality was elevated (SMR 1.16, 95% CI 1.03–1.28). Radiation-related cancers were in excess (SMR 1.20, 95% CI 1.03–1.36); however, the excesses could be attributed to tobacco and alcohol consumption. For smoking-related cancers, the SMR was 1.20 (95% CI 1.06–1.35) and for alcohol-related cancers the SMR was 1.56 (95% CI 1.26–1.86). Adjusted relative risks (ARR) of all-cause mortality were increased among workers who stayed in the Chernobyl area ≥ 92 days (ARR 1.20, 95% CI 1.08–1.34), were of non-Estonian ethnicity (ARR 1.33, 95% CI 1.19–1.47) or had lower (basic or less) education (ARR 1.63, 95% CI 1.45–1.83). Suicide mortality was increased (SMR 1.31, 95% CI 1.05–1.56), most notably among men with lower education (ARR 2.24, 95% CI 1.42–3.53). Our findings provide additional evidence that unhealthy behaviors such as alcohol and smoking play an important role in shaping cancer mortality patterns among Estonian Chernobyl cleanup workers. The excess number of suicides suggests long-term psychiatric and substance use problems tied to Chernobyl-related stressors, i.e., the psychosocial impact was greater than any direct carcinogenic effect of low-dose radiation.
Utilization of standardized preimplantation genetic testing for aneuploidy (PGT-A) via artificial intelligence (AI) technology is correlated with improved pregnancy outcomes in single thawed euploid embryo transfer (STEET) cycles
Authors: Buldo-Licciardi Julia , Large Michael J. , McCulloh David H. , McCaffrey Caroline , Grifo James A. 
Published: January 2023

Abstract
Purpose
To investigate the role of standardized preimplantation genetic testing for aneuploidy (PGT-A) using artificial intelligence (AI) in patients undergoing single thawed euploid embryo transfer (STEET) cycles.

Methods
Retrospective cohort study at a single, large university-based fertility center with patients undergoing in vitro fertilization (IVF) utilizing PGT-A from February 2015 to April 2020. Controls included embryos tested using subjective NGS. The first experimental group included embryos analyzed by NGS utilizing AI and machine learning (PGTaiSM Technology Platform, AI 1.0). The second group included embryos analyzed by AI 1.0 and SNP analysis (PGTai2.0, AI 2.0). Primary outcomes included rates of euploidy, aneuploidy and simple mosaicism. Secondary outcomes included rates of implantation (IR), clinical pregnancy (CPR), biochemical pregnancy (BPR), spontaneous abortion (SABR) and ongoing pregnancy and/or live birth (OP/LBR).

Results
A total of 24,908 embryos were analyzed, and classification rates using AI platforms were compared to subjective NGS. Overall, those tested via AI 1.0 showed a significantly increased euploidy rate (36.6% vs. 28.9%), decreased simple mosaicism rate (11.3% vs. 14.0%) and decreased aneuploidy rate (52.1% vs. 57.0%). Overall, those tested via AI 2.0 showed a significantly increased euploidy rate (35.0% vs. 28.9%) and decreased simple mosaicism rate (10.1% vs. 14.0%). Aneuploidy rate was insignificantly decreased when comparing AI 2.0 to NGS (54.8% vs. 57.0%). A total of 1,174 euploid embryos were transferred. The OP/LBR was significantly higher in the AI 2.0 group (70.3% vs. 61.7%). The BPR was significantly lower in the AI 2.0 group (4.6% vs. 11.8%).

Conclusion
Standardized PGT-A via AI significantly increases euploidy classification rates and OP/LBR, and decreases BPR when compared to standard NGS.
Anomalous grain growth in sintered Bi2Ca2Co2−xCuxOy + Ag ceramic composites by Cu doping
Authors: Amaveda H. , Madre M. A. , Mora M. , Torres M. A. , Sotelo A. 
Published: January 2023

AbstractBi2Ca2Co2 − xCuxOy + 4 wt%Ag (with x between 0 and 0.20) thermoelectric materials were prepared through a sol-gel method via nitrates. Powder XRD patterns showed the presence of thermoelectric phase as the major one, accompanied by metallic silver. SEM observations identified three different secondary phases in the samples, together with an exaggerated grain growth with Cu doping. The microstructural modifications are reflected in an important decrease of electrical resistivity, ∼ 3% when compared to undoped samples, due to the reduction on the number of grain boundaries, and the increase of Co4+ in the conducting layer. The minimum values at 650 ºC were obtained in 0.10 Cu-doped samples, 69 mΩ cm, which are lower than the reported in sintered samples. On the other hand, Seebeck coefficient was only slightly affected and reached the highest values at 650 ºC in 0.15 Cu-doped samples, 215 µV/K, which is practically the same measured in undoped ones, 211 µV/K, and lower than those reported for sintered samples. Consequently, the highest PF at 650 ºC has been determined in 0.10 Cu-doped samples, which is around 50% higher than the obtained in samples prepared through the classical solid-state method, or the undoped ones prepared in this work.
New York State’s Paid Family Leave Program is Associated with More Equitable and Increased Use of Paid Leave Following Childbirth
Authors: Nguyen Trang , Dennison Barbara A. , Radigan Anne , FitzPatrick Eileen , Zhang Wei , Ncube Butho 
Published: January 2023

Abstract
Objectives
This study aimed to assess changes in paid maternity leave before and after New York’s (NY) Paid Family Leave (PFL) law went into effect (1/1/2018) and changes in disparities by maternal characteristics.

Methods
We used specific data collected on maternity leaves by women who gave birth in 2016–2018 in NY State (outside NY City) participating in the Pregnancy Risk Assessment Monitoring System survey. Multiple logistic regressions were conducted to evaluate the effect of the PFL law on prevalence of paid leave taken by women after childbirth.

Results
After NY’s PFL law went into effect, there was a 26% relative increase in women taking paid leave after childbirth. Use of paid leave after childbirth increased among all racial and ethnic groups. The increases were greater among Black non-Hispanic or other race non-Hispanic women, compared to white non-Hispanic women, suggesting that NY’s law was associated with more equitable use of paid leave following childbirth.

Conclusions for Practice
Wider implementation and greater utilization of paid maternity leave policies would promote health equity and help reduce racial/ethnic disparities in maternal and child health outcomes.
Management accounting and new product development: a systematic literature review and future research directions
Authors: Magnacca Fabio , Giannetti Riccardo 
Published: January 2023

AbstractThis paper systematically reviews the existing literature at the crossroads of management accounting and new product development. At present, the accumulated knowledge on this topic is fragmented. Different research settings, diverse research focuses, and the use of different research methods are amongst the main reasons for the existing fragmentation and lack of an overall, conceptually coherent view of the knowledge gained on the management accounting phenomenon in new product development environments. As a response to the current knowledge fragmentation, the purpose of this paper is to consolidate existing evidence, provide an overview of the literature’s state-of-the-art, and propose paths for its future development. As a result of the systematisation attempt, this paper recognises the threefold identity of management accounting research in new product development and proposes a conceptual framework that collocates existing contributions along a research spectrum that gradually shifts the focus from the more technical-oriented aspects of management accounting to the more sociological-oriented aspects. Accordingly, this paper identifies the following research paths and systematise their relative contributions: (1) management accounting techniques and calculations; (2) management accounting information types and roles; (3) management accountants’ involvement and roles in new product development environments. Besides allowing the systematisation of previous investigations, this paper’s three research avenues provide a ‘lighthouse’ to those who, in future, aim to contribute to the current debate and knowledge creation at the intersection of management accounting and new product development. In this regard, the final part of the paper advances nine research propositions that emanate from the literature review and outlines a research agenda with directions for future research.
Un poema europeo en el romanticismo español: El bulto vestido del negro capuz (1835) de Patricio de la Escosura
Authors: Gutiérrez Sebastián Raquel 
Published: January 2023

AbstractThe article studies the narrative poem by Patricio de la Escosura El bulto vestido del negro capuz (1835), relating it to the European romantic literature of his time, which the author knew well from his stays as an emigrant in France. The work analyzes the themes and the form of a composition that is always cited but scarcely studied by contemporary and current critics. The analysis shows the connection of themes, motives and resources between this work and various productions by authors such as Byron, Schiller, Hugo and Vigni.
Improved indoor visible light positioning system using machine learning
Authors: Abdalmajeed Ahmed M. M. , Mahmoud Mohamed , El-Fikky Abd El-Rahman A. , Fayed Heba A. , Aly Moustafa H. 
Published: January 2023

AbstractIn this study, we present a novel Visible Light Positioning (VLP) method to reduce the localization error in an indoor environment. Machine Learning (ML) methods including Decision Tree (DT), Support Vector Machine (SVM), and Neural Networks (NNs) are used in combination with the LED Received Signal Strength (RSS) and the angle of a steerable laser. Zemax optics studio simulator is used to build a real indoor scene. Orange data mining software is utilized to apply ML techniques. Our numerical findings show that the suggested system outperforms the other RSS Visible Light Communication (VLC)-based models by reducing the localization error by more than 90% in some areas.
RETRACTED ARTICLE: Enhanced optical and thermal conductivity properties of barium titanate ceramic via strontium doping for thermo-optical applications
Authors: Tihtih Mohammed , Ibrahim Jamal Eldin F. M. , Basyooni Mohamed A. , En-nadir Redouane , Belaid Walid , Abdelfattah Mohamed M. , Hussainova Irina , Pszota Gábor , Kocserha István 
Published: January 2023

AbstractIn this study, we prepared a homogeneous fine powder of barium titanate (BaTiO3, BT) doped with different concentrations of strontium (x = 0, 0.05, 0.125, 0.15, 0.20, and 0.3) and having the composition Ba1-xSrxTiO3 (barium strontium titanate, BSrxT). XRD patterns and Rietveld refinement revealed the existence of a single tetragonal phase structure for BSrxT, x = 0–20%, and a single cubic structure for BSr30%T. The physical properties of the pure and doped mixtures were studied. The results showed that the addition of strontium to the physical properties of BaTiO3, including the apparent porosity, bulk density, linear shrinkage, and water absorption have been changed when increasing the Sr content. Moreover, the inclusion of 15% Sr in BaTiO3 increases the apparent porosity and water absorption of the sample to 6.2 and 28.5%, respectively. The optical properties were investigated by Ultraviolet–visible spectroscopy and it was found that the optical band gap decreases significantly with increasing Sr concentration, from 3.10 for pure BaTiO3 to 2.46 eV for the BSr30%T compound. The thermal conductivity measurements showed that the doping mechanism and the increased temperature have a significant effect on the thermal conductivity results of the fabricated ceramic materials. Therefore, it was found that the value of thermal conductivity increases with increasing Sr doping and at higher temperatures. A correlated behavior of optimum values is observed in band gap energy, absorption, and thermal conductivity which can be exploited for thermo-optical applications.
What is important to adults after lower limb reconstruction surgery: a conceptual framework
Authors: Leggett Heather , Scantlebury Arabella , Hewitt Catherine , Sharma Hemant , McDaid Catriona ,   The PROLLIT Study Collaborators, Adamson Joy , Cocks Kim , Harwood Paul , Ferguson David , Hamdy Reggie , Ferreira Nando 
Published: January 2023

Abstract
Purpose
Patient-reported outcome measures (PROMs) are used to understand the impact of lower limb reconstruction on patient’s Health-Related Quality of Life (HRQL). Existing measures have not involved this group of patients and their experiences during development. This study aimed to develop a conceptual framework to reflect what is important to patients requiring, undergoing or after undergoing reconstructive surgery.

Methods
Our population of interest was people requiring, undergoing or after undergoing reconstructive surgery due to trauma, malunion, nonunion, infection or congenital issues treated by internal or external fixation. We undertook semi-structured interviews with patients and orthopaedic healthcare professionals (surgeons, methodologists and patient contributors) in England.

Results
Thirty-two patients and 22 orthopaedic healthcare professionals (surgeons, methodologists and patient contributors) were interviewed between November 2020 and June 2021. Eight domains from a previously developed preliminary conceptual framework were used as a framework around which to code the interviews using thematic analysis. Six domains important to patients (from the perspective of patients and orthopaedic healthcare professionals) were included in the final conceptual framework: pain, perception-of-self, work and finances, daily lifestyle and functioning, emotional well-being, and support. These findings, plus meetings with our advisory panel led to the refinement of the conceptual framework.

Conclusion
The first five domains relate to important outcomes for patients; they are all inter-related and their importance to patients changed throughout recovery. The final domain—support (from work, the hospital, physiotherapists and family/friends)—was vital to patients and lessened the negative impact of the other domains on their HRQL. These new data strengthen our original findings and our understanding of the domains we identified in the QES. The next step in this research is to ascertain whether current PROMs used with this group of patients adequately capture these areas of importance.
Ghosts and Punks: The Aesthetics of Copyright Law in Graphic Novels and Comics
Authors: Stockton-Brown Melanie 
Published: January 2023

AbstractGraphic justice and the law of aesthetics have in very recent years successfully brought law, aesthetics and comics scholarship into the same space. The culture of copyright infringement within comics (including in the Marvel, DC, and Disney universes) has been extensively in the literature by scholars including Saval. How copyright law is portrayed within the graphic novels and comics themselves is the focus (and contribution of) this article. This article will explore several comics and graphic novels, as well as included this author’s reflections of portraying copyright visually within zines for public dissemination. Throughout this article, the discourses of ghosts and spectres that are interwoven with copyright law and haunt the texts will be seen, as will the discourses of oppression and warfare that are involved for anyone seeking to make use of copyright works. As Gómez Romero and Dahlman note, comics offer “an alternative legal discourse” and we can see these alternative legal discourses through their aesthetic graphic form. This article will consider: the aesthetic portrayal of copyright law in A Gift for a Ghost and Josie and the Pussycats No. 6; as well as Bound by Law, Theft! A History of Music, and Pictures within Pictures. These comics and graphic novels have been chosen as they aesthetically portray copyright law and copyright infringement (referred to in some of the comics as “plagiarism”), and others aesthetically portray the public domain and fair use. In viewing these aesthetic manifestation of copyright law, the reader understands the limiting nature of copyright on creative freedoms, and that copyright law’s power is absolute. This article will explore the following: (i) copyright’s aesthetic portrayals and the impact of this; (ii) comics haunted by copyright law, considering A Gift for A Ghost and Josie and the Pussycats; (iii) comics about the necessity of the public domain and fair use, considering Bound by Law, Theft! A History of Music, and Pictures within Pictures; and (iv) self-reflections on portraying copyright aesthetically in publicly disseminated research zines. This article has not set out to determine that certain visual aesthetic portrayals are “correct” or “better”, but rather to explore how legal discourses and narratives about copyright law are circulated through the comics medium. These visual depictions hold considerable weight, and it is striking to see similar narratives used across a range of comics works, with different intended audiences. What is clear is that the visual depiction of copyright law enables a greater ability to convey the multiple copyright law discourses that can be felt at once, and also to highlight that some of these discourses are contradictory to one another.
Particles, fields, and the ontology of the standard model
Authors: Benitez Federico 
Published: January 2023

AbstractIn this work we discuss issues of ontological commitment towards one of the most important examples of contemporary fundamental science: the standard model of particle physics. We present a new form of selective structural realism, which uses as its basis the distinction between what have been called framework and interaction theories. This allows us to advance the ongoing debate about the ontological status of (quasi-)particles and quantum fields, by emphasising the distinction between quantum field theory serving as a framework, and the standard model itself, which we argue is an interaction theory embedded within this framework. Following a discussion of what ontological commitments corresponds to each of these two classes, we argue that some of the previous proposals in the literature might have been misguided by the blending of quantum field theory and the standard model into an undifferentiated unity, and defend a moderate form of object realism with respect to particle-like entities.