bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ABIC score for Assessing Long-term Outcomes in Elderly Hospitalized Patients with Acute Exacerbations of Chronic Heart Failure
Authors: Lin Zebin , Deng Manxiang , Xiao Li , Qi Chenlu , Song Siqi , Zhao Yiping 
Published: March 2023

Abstract
Objectives: Age-bilirubin-international normalized ratio -creatinine (ABIC) score was originally proposed as a tool to assess alcoholic hepatitis survival and to identify patients who respond to corticosteroid treatment. Since the components of this score are associated with prognosis in patients with heart failure, the purpose of this study was to determine the relationship between ABIC score and long-term prognosis of elderly patients with acute exacerbation of chronic heart failure.
Methods: This is a retrospective cohort study of elderly patients with acute exacerbation of chronic heart failure who were hospitalized for the first time in the Second Affiliated Hospital of Chongqing Medical University from February 2017 to December 2017. The main clinical outcome was all-cause mortality within three years. Cox regression and Lasso regression were used to screen variables and build a prognostic model. Combined with the ABIC score, the final model was adjusted, and the predictive ability of the model was evaluated. The screened variables with ABIC score were incorporated into the multivariate Cox regression analysis and a nomogram prediction model was built. The receiver operating characteristic curve and calibration curve were used to evaluate the predictive ability and accuracy of the model, respectively.
Results: A total of 365 patients with acute exacerbation of chronic heart failure were included (median age 78 years, 50.7% female). During the 3-year follow-up period, 87 patients experienced all-cause death, including 53 cardiac deaths. A total of 4 variables (NT-proBNP, BUN, RDW-CV and prealbumin) were screened by univariate Cox regression analysis and Lasso regression analysis. The multivariate COX regression results showed that the risk of death increased by 33% with the increase of ABIC score by 1 point (after correcting NT-proBNP, BUN, RDW-CV and prealbumin). The results of ROC curve analysis show that the area under the curve (AUC) of the ABIC score is 0.685, while the AUC of the Nomograph including the ABIC score is 0.840.
Conclusions: The ABIC score is associated with long-term adverse outcomes in elderly hospitalized patients with chronic heart failure exacerbations. But its predictive ability for adverse events needs further exploration.
A VV-ECMO supported severe pneumonia caused by Chlamydia abortus: a case report
Authors: Yip wahkwong , wu bin , ye baohua , ji chengyi , wu ziyao , chen minli , lin chunmiao , Ye Jialiang , ke wenzhi , chen qiuyan , xu shumin , chen huimin 
Published: March 2023

Abstract

Background:
Human infection with Chlamydia abortus is very rare, mainly described as septicemia and abortion in pregnant women with previous Chlamydia abortus exposure. Though there is a case of atypical pneumonia caused by Chlamydia abortus in 2016, none of the reported infections manifested primarily as severe hypoxemia.
Case Presentation:
A 69-year-old male farmer admitted to our ICU for pneumonia caused severe hypoxemia, with PaO2 /FiO2 ratio dropped to 53.1 mmHg when under mechanical ventilation. Bronchoalveolar lavage fluid(BALF) for untargeted metagenomic NGS was taken soon after VV- ECMO support. Sequencing results indicate Chlamydia abortus is the pathogen. The patient operated a farm raising more than a hundred pigs and some poultry before the disease, with no ruminant in the farm, and the possibility of contact was denied. Two weeks later, the patient was weaned from ECMO, recovered, and was discharged a month later.
Conclusion:
Chlamydia abortus infection in humans may as well cause severe pneumonia with hypoxemia and need ECMO support. clinician veterinarians and public health officials should be aware of possible severe pulmonary infection due to Chlamydia abortus.
Astrocytes mediate cerebral blood flow and neuronal response to cocaine in prefrontal cortex
Authors: Pan Yingtian , Du Congwu , Park Kicheon , Hua Yueming , Volkow Nora 
Published: March 2023

Abstract
Cocaine affects both cerebral blood vessels and neuronal activity in brain. Cocaine can also disrupt astrocytes, which are involved in neurovascular coupling process that modulates cerebral hemodynamics in response to neuronal activity. However, separating neuronal and astrocytic effects from cocaine’s direct vasoactive effects is challenging, partially due to limitations of neuroimaging techniques to differentiate vascular from neuronal and glial effects at high temporal and spatial resolutions. Here, we used a newly-developed multi-channel fluorescence and optical coherence Doppler microscope (fl-ODM) that allows for simultaneous measurements of neuronal and astrocytic activities alongside their vascular interactions in vivo to address this challenge. Using green and red genetically-encoded Ca2+ indicators differentially expressed in astrocytes and neurons, fl-ODM enabled concomitant imaging of large-scale astrocytic and neuronal Ca2+ fluorescence and 3D cerebral blood flow velocity (CBFv) in vascular networks in the mouse cortex. We assessed cocaine’s effects in the prefrontal cortex (PFC) and found that the CBFv changes triggered by cocaine were temporally correlated with astrocytic Ca2 +A activity. Chemogenetic inhibition of astrocytes during the baseline state resulted in blood vessel dilation and CBFv increases but did not affect neuronal activity, suggesting modulation of spontaneous blood vessel’s vascular tone by astrocytes. Chemogenetic inhibition of astrocytes during cocaine challenge prevented its vasoconstricting effects alongside the CBFv decreases but also attenuated the neuronal Ca2 +N increases triggered by cocaine. These results document a role of astrocytes both in regulating vascular tone of blood flow at baseline and for mediating the vasoconstricting responses to cocaine as well as its neuronal activation in the PFC. Strategies to inhibit astrocytic activity could offer promise for ameliorating vascular and neuronal toxicity from cocaine misuse.
Self-Locking Kirigami Surfaces via Controlled Stretching
Authors: Zhang Qian , Pan Ning , Liu Shuangbo , Feng Jian , Cai Jianguo 
Published: March 2023

Abstract
Kirigami provides a powerful strategy to transform two-dimensional elements into complex three-dimensional functional structures with lengths ranging from nanoscale to microscale and macroscale. The stability of mechanically induced forming three-dimensional structures using external or self-balancing actuation is crucial. The applicability of the actuator method to the modularity and programmability of the kirigami element is also a key issue in the forming process. Here, we offer a three-dimensional self-locking element forming pattern achieved by in-plane tension and release, manifested as a combination behavior of out-plane popping and rotation. The range of geometric parameters for kirigami elements with different stability properties is determined theoretically. And the in-plane tension conditions are also calculated to break the transition point of the forming process. The horizontal and vertical modular array analysis demonstrates the scalability and programmability from the self-locking elements to the kirigami surfaces. We expect that the kirigami pattern and design approach will serve for innovative systems, including tunable antennas, flexible electronics, and medical devices.
Spatio-spectral 4D Coherent Ranging Using a Flutter-wavelength-swept Laser
Authors: Jeong Dawoon , Jung Min Uk , Jang Hansol , Jeong Taeho , Kim Hyunsoo , Yang Sanghyeok , Lee Janghyeon , Kim Chang-Seok 
Published: March 2023

Abstract
Coherent light detection and ranging (LiDAR), particularly the frequency-modulated continuous-wave LiDAR, is a powerful optical imaging technology for long-distance three-dimensional (3D) ranging and velocity measurement. Spatio-spectral LiDAR was proposed to perform coherent ranging and solid-state beam scanning simultaneously; however, a complete four-dimensional (4D) implementation, combined with 3D distance and velocity measurements over tens of meters, has not yet been reported owing to the limitations of commercial wavelength-swept lasers. Herein, we propose a novel flutter-wavelength-swept laser that offers a simultaneous yet independent wavelength modulation of 5–6 pm for axial distance and velocity measurement, and a wavelength sweep of 160 nm for horizontal beam scanning. An acousto-optical scanner was synchronized to support the remaining vertical beam scanning for a perfect solid-state coherent LiDAR. The proposed spatio-spectral LiDAR system achieves a high-resolution coherent ranging over 20 m and 4D real-time imaging with 200 × 45 pixels in a 10 Hz frame rate.
Impact of CNT addition on Surface Roughness and Dimensional Characteristics of Polymer Nano-Composite Fabricated by FDM method
Authors: Mohanavel V. , Kannan S. , Mohan R. , Arul K. , Seikh A.H , Iqbal A. 
Published: March 2023

Abstract
Nowadays, companies frequently employ additive manufacturing or 3D printing technologies to check the fitting, shape, and functioning of a planned product preceding design approval and implementation. As additive manufacturing does not require process design, jigs, fixtures, specialized tool path creation, etc., it minimizes the overall manufacturing duration as compared to traditional production. Fused deposition modeling is the kind of additive manufacturing technology that is most frequently employed in the industry. In order for fused deposition modeling to function, extrusion polymer from a nozzle that is preheated between the flow and melting temperature must be deposited layer after layer.The current experimental investigation examines the effect of carbon nanotube addition into the polylactic (PLA) polymer matrix using the fused deposition modeling technique. By combining polylactic acid with carbon nanotubes in the amounts of 0 percent, 0.5 percent, 1 percent, 1.5 percent, and 2 weight percent, an innovative thermoplastic nanocomposite was created. Twin-screw extrusion was employed to create the composite filament. After the successful fabrication of nanocomposites, the effect of varying concentration nanotube addition on the microstructure, surface roughness, and dimensional accuracy of FDM parts was studied. With the incorporation of carbon nanotube, the surface roughness appeared to decrease along the building direction. To comprehend the dispersion of graphene in the PLA matrix and its effects on the study's parameters, these properties were examined.
The importance of oral health in patients with T2DM: A cross-sectional study.
Authors: Zhang Dongxue , Cheng Qian , Liu Wenyan , Zhang Tianyi , Ding Yukun , Fan Jing , Gu Yanan , Li Yufeng , Lin Mei 
Published: March 2023

Abstract
Objective To evaluate the association between systemic factors and periodontal status in patients with type 2 diabetes mellitus (T2DM).
Methods A total of 169 patients with T2DM and periodontitis were included in this study. Patients were divided into three groups: mild periodontitis, moderate periodontitis and severe periodontitis. Periodontal parameters (PD, CAL and BI) were evaluated. FPG, HbA1c and Hs-CRP levels were measured in fasting venous blood. The association between insulin use and severity of periodontitis was investigated in ordered logistic and binomial logistic regression models.
Results Ordered logistic regression analysis showed insulin use had a statistically significant influence on severity of periodontitis: OR 2.36 [95%CI: 1.23-4.55, P=0.010] after adjusting for age and gender; OR 2.10 [95%CI: 1.05-4.18, P=0.035] after adjusting for age, gender, smoking status, daily toothbrushing frequency and HbA1c level; OR 2.04 [95%CI: 1.01-4.14, P=0.048] after adjusting for age, gender, smoking status, daily toothbrushing frequency BMI, HbA1c level, FPG, statin and biguanide use. Binomial logistic regression models showed an association between insulin use and moderate to severe periodontitis: OR 2.44 [95% CI: 1.24-4.94, P=0.011] after adjusting for age and gender; OR 2.17 [95% CI: 1.07-4.53, P=0.035] after adjusting for age, gender, smoking status, daily toothbrushing frequency and HbA1c level; OR 2.13 [95% CI: 1.03-4.56, P=0.046] after adjusting for age, gender, smoking status, daily toothbrushing frequency BMI, HbA1c level, FPG, statin and biguanide use.
Conclusion Patients with T2DM who require insulin injections have a high risk for moderate to severe periodontitis and should be provided oral health education.
Analysis of the characteristics of the organisms，risk factors and preventive strategies for infection after colorectal cancer surgery
Authors: Hou Xidong , Liu Mengxing , Gu Huawei , Li Dan , Lin Mingzhu 
Published: March 2023

Abstract
Background Internal hospital infection is one of the major public health concerns worldwide. To investigate the etiological characteristics and risk factors of infections after colorectal cancer(CRC) surgery and the formulation of targeted infection control strategies.
Methods This is a retrospective analysis of 1500 patients from colorectal cancer patients from General Surgery between March 2018 and March 2022，Anyang Tumor Hospital. Based on pathogen distribution and results of drug sensitivity testing, pattern of pathogens and drug resistance in infection in hospitalized patients with with colonic malignancy were analyzed. We conducted univariate and multivariate logistic regression analyses to determine the risk factors of infections that are associated with postoperative colorectal cancer.
Results Infection cases were noted in 5.20% of all 1500 cases (78 of 1500 CRC patients). Drug resistance pattern showed that 88.89% of the implicated coagulase-negative staphylococci species and 40% of the implicated Acinetobacter species were meropenem-resistant. Considering all infection sites, age >60 years (OR=2.190, P=0.002), diabetes mellitus (OR=2.044, P=0.005), operation time >3h (OR=2.178, P=0.002) ), hospitalization time >10d (OR=1.793, P=0.017), parenteral nutrition (OR=2.797, P=0.000), indwelling catheter (OR=1.699, P=0.038), mechanical ventilation (OR=2.294, P=0.001) and the usage of drainage tube (OR=3.455, P=0.000) were risk factors at multivariate analysis.
Conclusions: Post-operative infections may negatively affect surgical outcomes. Based on the greatest available evidence,important preoperative risk factors for postoperative colorectal cancer infections have been identified. Knowledge on risk factors may influence treatment and procedure-related decisions, and possibly reduce the postoperative infection rate.
Urinary cortisol level in exclusion autonomous cortisol secretion in the patient of primary aldosteronism
Authors: Chu Wen-Kai , Wang Chih-Yuan , Wu Wan-Chen , Wu Vin-Cent 
Published: March 2023

Abstract

Background
Serum cortisol level after 1-mg overnight dexamethasone suppression test (1-mg DST) below 1.8 ug/dL was a diagnostic criterion for having autonomous cortisol secretion (ACS), whether the cut-off point in 24-hour urine-free cortisol (24-h UFC) for the patient suspecting with primary aldosteronism (PA) concomitant ACS is unclear.
Methods
This prospective observational study enrolled 274 patients diagnosed with PA from January 2017 to January 2020 (male, 42.3%; mean age, 55.9 ± 11.7 years). Serum cortisol level after 1 mg DST over 1.8 ug/dL was a diagnostic criterion for ACS, confirmed with a second repeated test.
Results
Of the 274 PA patients, 74 patients (27%) with PA had concomitant ACS while the other 200 patients were not. Logistic regression analysis showed patients with PA concomitant ACS were associated with higher 24-h UFC (OR, 1.91 [95% CI, 1.06–3.41], P=0.03), older age (OR, 1.04 [95% CI, 1.01–1.07], P=0.008), and diabetes mellitus (OR, 2.4 [95% CI, 1.12–5.12], P=0.025). The generalized additive model (GAM) for urinary cortisol and ACS showed the 24-h UFC above 36 μg, concurrent with the positive predictive value of 32.6% and negative predictive value of 77.9% could be a factor predicting a higher possibility of ACS.
Conclusions
More than a quarter of PA patients concomitant ACS. Our study suggested the 24-h UFC less than 36 μg as a cut-off point in exclusion of the patient with PA concomitant ACS. Additionally, older age and diabetes mellitus were also risk factors for predicting patients with PA concomitant ACS.
Development of a Figure of Merit for the Optimisation of Antennas for the X-Band All Sky Survey
Authors: Kriel Scott Graham Hilton , de Villiers Dirk Izak Leon 
Published: March 2023

Abstract
The X-Band All-Sky Survey (X-BASS) is a planned radio astronomy experiment aimed at mapping the sky in both temperature and polarisation. The main purpose of X-BASS is to aid observations of the cosmic microwave background (CMB) by removing various contaminating foreground emissions present in the galaxy, such as synchrotron and thermal dust emissions. When designing the antenna for such an instrument, one must rely on traditional figures of merit (FoMs) used to describe the performance of antenna radiation pattern characteristics. However, these FoMs often have a conflicting nature, the optimal trade-off of which may not be immediately apparent. What is more, traditional FoMs are usually developed from a telecommunications standpoint or determined heuristically from other radio astronomy projects with differing goals. Thus, the exact effect of antenna pattern characteristics on the end science goals of the experiment may be unclear. As such, this paper seeks to determine the limitations posed by antenna noise temperature, beamwidth and cross-polarisation on the end science goal of the experiment, which is the determination of various cosmological parameters through observation of the CMB. From this, a new FoM was developed which provides a single metric to be used in the optimisation of the antenna structure. This FoM was then used in the preliminary design of a corrugated horn antenna to feed the X-BASS reflector system.
New STEP-NC compliant system to Automatic Process Planning for Turning Process
Authors: Elmesbahi Abdelilah , Buj-Corral Irene , Mesbahi Jihad EL , Bensaid Oussama 
Published: March 2023

Abstract

STEP-NC is a smart standard, developed by the International Standard of Organization ISO, to substitute the ISO 6983 G-code, because, the language G-Code, normally used for Computer Numerical Control (CNC), is qualified to be not able to links CAD/CAM/CNC digital chain and ensure the exigencies of modern intelligent manufacturing in terms of tractability, interoperability, flexibility, adaptability, and extensibility. Therefore, the first objective of this paper is to design and implement a Computer Automatic Aided Process for Turning process, designated by CAPP-Turn, to ensure machining of rotational parts within this modern vision. However, to achieve CAPP-Turn system, it is compulsory to build a robust Automatic Manufacturing Features Recognition AMFR module to establish a full communication between the first two links of the digital chain which are Design CAD and Manufacturing CAM. that's why, by using a hybrid graph-rules method, the second objective of this works is focused on elaboration of a new consistent-fast algorithm that allow extraction of the machining turning entities for parts with most efficiency and complex geometry. In fact, in the literature, most of the presented AMFR systems are restricted of external turning process and cannot handle parts with complex geometry and interacting features. Moreover, the frontal turning features are almost neglected in most of these systems, despite their importance for fulfilling certain functions in mechanical systems. This article, in first, details the global architecture of the CAPP-turn and describe clearly trades between the CAD part and STEP-NC output file. In second, it explains model of the Automatic Manufacturing Feature Recognition (AMFR) system. This system encompasses: (i) a parser module that translates geometric and topological data, from STEP AP203 CAD file, into Python entity class’s objects; (ii) an AMFR that analyses the created-objects and applies predefined-rules to construct all possible turning machining (iii) a Module capable to select external features from internal, frontal features from axial and handle interacting features from the simples. Afterwards, these steps, the AMFR gives all suitable sequencings for part machining. At the end, with a goal to demonstrate the potential advantages and power of proposed the proposed AMFR, a selective part is chosen for the test. The result shows that AMFR performs well on recognizing all types of features indifferently of their types: Internal or external, axial or frontal, simple or interacting.
Weighted weak estimate for commutators of fractional Marcinkiewicz integrals over non-homogeneous metric spaces
Authors: Tao Xiangxing , Feng Shuaijun 
Published: March 2023

Abstract
Let (X, d, μ) be a non-homogeneous metric measure space, which satisfies the geometrically doubling condition and the upper doubling condition. In this paper, under the assumption that the fractional Marcinkiewicz integral operator Mβ,ρ,q is bounded on L2(X, μ), the authors prove the weak type weighted Lp(ω) boundedness of the commutators Mbβ,ρ,q with the RBMO(μ) function b.
MSC: 42B20; 42B25
Suffering in Silence. Population-Level Detection and Risk-Prediction of Women’s Reproductive Disease from Claims Data
Authors: Rudinac Maja , Moirogiannis Dimitrios , Baker Katie , Makridakis Thodoris , Atsonios Ioannis 
Published: March 2023

Abstract
We present a new approach to population health where data-driven predictive models are learned for various stigmatized, underserved, and neglected chronic conditions that affect women. Our approach enables early detection within large populations at low cost from readily available medical claims datasets. The model uncovers early and late stage risk factors up to two years in advance of onset that can be used as guides for early interventions for endometriosis, polycystic ovarian syndrome, and infertility, allowing women suffering from these conditions to get on treatment plans earlier.
Regulatory Effects and Mechanism of Immune Inhibitory Receptor LAIR-1 in Non-small Cell Lung Cancer
Authors: Yu Shuo , Yu Ruoxi , Liu Dan , Song Weikang , Duan Xuming , Sun Deyu , Qu Yanli 
Published: March 2023

Abstract
Purpose To investigate the association of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) levels with clinicopathological features and prognosis of non-small cell lung cancer (NSCLC).
Methods The expression of LAIR-1 and clinicopathological data were downloaded from The Cancer Genome Atlas database and Gene Expression Omnibus for analyzing the correlation between LAIR-1 expression and prognosis. Tissue samples from 118 NSCLC patients and 47 paired adjacent cancer tissues were collected and the expression of LAIR-1 in NSCLC tissues was detected by immunohistochemistry. The statistical analysis was performed for association analysis of LAIR-1 expression and clinicopathological properties. Lentiviral transfection of NSCLC cell lines A549 and SK-MES-1 for overexpressing LAIR-1 were used to evaluate the role of LAIR-1 in regulating cell cycle and apoptosis in NSCLC cell lines by flow cytometry.
Results LAIR-1 expression was lower in NSCLC tissues than in para-cancerous tumor tissues, and overall survival time was lower in the LAIR-1 low- expression group. Univariate analysis revealed that the low expression of LAIR-1 was related to lymph node metastasis, tumor stage, etc. in NSCLC patients. The LAIR-1 low-expression group of the NSCLC patients showed higher mortality, tumor progression, and lower overall survival and disease-free survival. Multivariate analyses demonstrated that the expression of LAIR-1 in squamous carcinoma patients had a negative correlation with NSCLC progression. In vitro experiments showed that the overexpression of LAIR-1 blocked the squamous cell carcinoma at the G1 stage and promoted cell apoptosis.
Conclusion LAIR-1 was closely associated with lymph node metastasis, tumor stage, and patients’ prognosis.