bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application Analysis of Immersive Technology Based on Embedded Image System in Animated Character Images
Authors: Liu Fangfei 
Published: July 2023

Abstract
In recent years, with the rapid development of embedded technology and the application of network systems, the training and teaching of embedded image system technology have been promoted to solve the problem of slow update and development of materials and laboratory equipment. Immersive 3D animation technology has begun to flourish in the field of visual performances such as film and television, education, and entertainment. Compared with other new technologies, immersive technology can make movies more realistic and bring audiences a more realistic immersive experience. Although the traditional 3D technology is very mature and rich in content, the development of the comprehensive 3D content industry at home and abroad is mainly focused on hardware development, so there are relatively few content libraries related to this, and there is still a lot of room for development. The original animation character creation was mainly based on the mastery of hand-painted technology and key frame skills, but due to the limitations of this technology, the animation production wasted a lot of manpower, resources and time, and the intelligence of the characters and group action behaviors could not be guaranteed. Therefore, the research of image design based on intelligent algorithms has attracted more and more attention from most scientists. Characters, scenes, and character actions and behaviors are the three major elements in animation production, and they are also the key elements that reflect the effects of animation. The fast and effective way to shape the characters, the vivid and realistic performance of the group behavior, represents the quality of animation production. Through the research of immersive technology based on embedded image system, this paper applies it to the research of animated character image, aiming to promote its better development.
Failure behavior of a notched plate repaired by a hybrid repair technique (Stop hole bonded composite
Authors: BELHAMIANI Mohamed , Djebbar Noureddine , Oudad Wahid , Bouzitouna Wahiba Nesrine 
Published: July 2023

Abstract
Generally, bonded repairs are only approved if the primary aircraft structure is cracked and the residual strength significantly exceeds the design limit charge before the bonded repair can be applied.. In order to improve the maintenance effect of the stop hole approach for cracks, a solution of using both techniques (stop hole / bonded composite repairs) are proposed and investigated by finite element analysis. This work presents a study on the effectiveness of the hybrid repair technique in notched panels using both stop drilling hole and bonded composite repair techniques. Several parameters are taken into account: the diameter of the size of hole drilling, the width and the thickness of the composite patch and other parameters are modeled with a elastoplastic behavior of the plate using Abaqus software. A limit-load analysis determines a lower bound to the limit charge of a component and provides an alternative way to estimate plastic collapse for the limit loads. In addition, the limit load analysis had helped to provide an evaluation of the behaviors of structures or components for other failures. The plastic limit load (PLL) was evaluated by a convergent load increment in a wellconfigured finite element analysis with a load of a sufficiently small increment for an elastic-perfectly plastic behavior of the structure. The allowable limit stress on the aircraft is calculated by applying design factors to the plastic limit load (PLL) so that the onset of plastic collapse does not occur. The results proved that the hybrid repair provided the largest percentage in terms of maintenance and the smallest values for the notch stress intensity factor (NSIF) and von Mises stress for most of the hybrid configuration compared to the single repair technique.
Phytochemicals, antioxidant activity and essential oil components of Mentha longifolia genotypes
Authors: Tabar Fezzeh Mohammadi , Fathi Shahnaz , Shameh Shahla , Alirezalu Abolfazl 
Published: July 2023

Abstract
Mentha longifolia is one of the most important aromatic and native plants of Iran and has a wide range of applications in the pharmaceutical, food and cosmetic industries. In the present study, the phytochemicals and essential oil components, and antioxidant activity of 30 genotypes of M. longifolia were studied. The maximum amount of chlorophyll a (0.40 mg g− 1 DW), chlorophyll b (0.23 mg g− 1 DW) and total carotenoid content (18.59 µg g− 1 DW) were obtained in G26, while beta carotene (0.026 µg g− 1 DW) was obtained in G27. Total phenol content, flavonoid content and antioxidant activity by DPPH method ranged between 5.97–16.06 mg GAE g− 1 DW, 0.59–3.60 mg quercetin g− 1 DW and 3.34–15.72 mg AAE g− 1 DW, respectively. The highest levels of total anthocyanin content (9.30 µmol g− 1 DW) and soluble carbohydrate content (2.01 mg g− 1 DW) were recorded in G10 and G29, respectively. GC-MS analysis revealed that piperitenone oxide (from1.17 to 69.12%), pulegone (from 2.97 to 67.82%), cis-piperitenone oxide (from 0.78 to 24.89%), thymol (from 0.14 to 22.90%) 1, 8-Cineole (from 0.97to 22.54%), p-menthone (from 0.17 to 15.42%) were as the main ingredients in 30 studied genotypes. Genotypes were divided into four classes based on Hierarchical cluster heat map analysis. Correlation analysis also showed a good relationship between essential oil constituents and evaluated phytochemical compounds. According to the results of this study, the essential oil of M. Longifolia genotypes can be a suitable candidate for use in various pharmaceutical, food and cosmetic industries.
Environmental enrichment improves the recognition memory in adult mice following social isolation via downregulation of Kv4.2 potassium channels
Authors: Shang Qing , Dong Yi-Bei , Xu Le , Yang Jian-Hong , Li Jia-Wen , Yu Wei-Yi , Sun Jie , Gao Xiang , Huang Yi , Zhang Xiao-Qin 
Published: July 2023

Abstract
The recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Social isolation (SI) has been implicated as a detrimental factor for recognition memory. The medial prefrontal cortex (mPFC) has been shown to carry information concerning the relative familiarity of individual stimuli, and modulating neuronal function in this region may contribute to recognition memory. The present study aimed to investigate the neuronal mechanisms in the mPFC of environmental enrichment (EE) on recognition memory in adult mice following SI. Mice were assigned into three groups: Control, SI, and SI + EE group. Novel location recognition (NLR) and Novel object recognition (NOR) tests were performed to evaluate the recognition memory. The levels of Kv4 channels were assessed by qRT-PCR and Western blotting. The effects of SI and SI + EE on the intrinsic excitability of pyramidal neurons in the mPFC were measured using whole-cell recording. We found that SI led to a reduction in the intrinsic excitability of pyramidal neurons. Specifically, we have identified that the reduction in the firing activity of pyramidal neurons resulted from alterations in the function and expression of Kv4.2 channels. Furthermore, EE regulated Kv4.2 channels, normalized the activity of pyramidal neurons and restored the behavioral deficits following SI. Thus, the roles of Kv4.2 channels in intrinsic excitability of pyramidal neurons suggest that the Kv4.2 channels present a promising therapeutic target for recognition memory impairment.
Salvianolic acid B attenuates renal fibrosis in rat model of unilateral ureteral obstruction
Authors: yu wenjuan , zhao bei , yao gang , zhong haizhen 
Published: July 2023

Abstract
Background: Renal fibrosis is the most common pathological type in the development of chronic kidney disease, in which oxidative stress plays an important role. Nuclear factor E2 related factor 2(Nrf2) is an important transcription factor to regulate oxidative stress response. In this article we investigated antioxidant salvianolic acid B(SAB) on oxidative stress induced renal fibrosis targeting Nrf2.
Methods: 45 rats aged 7-8 weeks were divided into control group, unilateral ureteral obstruction(UUO) group and SAB group. Salvianolic acid B was used to treat rats with unilateral ureteral obstruction until the seventh day after operation. The degree of renal tubular injury and fibrosis were observed by histopathological examination. Nrf2, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1(NQO1) were detected to evaluate the degree of renal fibrosis and oxidative stress.
Results: Salvianolic acid B could reduce renal tubular injury and interstitial fibrosis in UUO rats. Salvianolic acid B increased HO-1, NQO-1 and the nuclear expression of Nrf2, however the expression of total Nrf2 protein and Kelch-like ECH associated protein 1(Keap1) were not affected.
Conclusion: Salvianolic acid B may reduce oxidative stress and renal interstitial fibrosis through Nrf2 nuclear translocation.
Multi-center study on mortality in children, and adults with sickle cell anemia-risk factors and causes of death
Authors: Alkindi Salam , Al-Jadidi Salma , Al-Adawi Safa , Elsadek Rifaat Abdullah , Madhani Ali Al , Al-Nabhani Maryam , Pathare Anil V 
Published: July 2023

Abstract
Sickle cell disease (SCD) is a major public health burden worldwide with increasing morbidity and mortality. We studied the risk factors associated with mortality in SCD patients, between the years 2006 and 2020 at three hospitals in Oman. We analyzed clinical manifestations, haematological, biochemical, and radiological parameters, use of antibiotics, and blood and exchange transfusions. Our cohort included 123 patients (82 males, 41 females), with a median age of 27 (IQ 21–35 years). SCD related complications included acute chest syndrome (ACS) in 52.8%, splenic sequestration in 21.1%, right upper quadrant syndrome in 19.5%, more than > 6 VOC /year in 17.9%, and stroke in 13.8%. At the terminal event, patients had cough, reduced O2 saturation, crepitation and fever in 24.4%, 49.6%, 53.6% and 68.3% respectively. Abnormal chest x-ray and chest CT scan were seen in 57.7%, and 76.4% respectively. Laboratory parameters showed a significant drop in hemoglobin (Hb) and platelet counts from baseline, with a significant rise in WBC, LDH and CRP from baseline (p < 0.05, Wilcoxon Signed Ranks test).. All patients received antibiotics, whereas, 95.9% & 93.5% received simple blood transfusions, and exchange transfusions respectively, and 66.6% required non-invasive ventilation. Among the causes of death, ACS is seen in 32 (26%), sepsis in 49 (40%), and miscellaneous in 42 (34%). Sudden death was seen in 32 (26%) of patients. Male gender, with low HbF, rapid drop in Hb and platelet, and increased in WBC, LDH, ferritin, and CRP, correlated significantly with mortality in this cohort.
Is the use of diagnostic imaging and the self-reported clinical management of low back pain patients influenced by the attitudes and beliefs of chiropractors? A survey of chiropractors in the Netherlands and Belgium
Authors: Vossen Brenda L. van der , de Zoete Annemarie , Rubinstein Sidney M. , Ostelo Raymond W.J.G. , de Boer Michiel R. 
Published: July 2023

Abstract
Background
No previous studies have examined the association between attitudes and beliefs of chiropractors and their adherence to low back pain (LBP) guidelines. The aim of this study is: 1) to assess the attitudes and beliefs towards the management of LBP of Dutch and Belgian chiropractors; and 2) to investigate the association of these attitudes and beliefs on the use of diagnostic imaging and on the adherence to diagnostic guidelines and guidelines in the management of patients with LBP.
Methods
Study design: cross-sectional study using a web-based questionnaire in chiropractic private practice in the Netherlands and Belgium. The survey included sociodemographic characteristics, use of diagnostic imaging, the Pain Attitude and Beliefs Scale-Physiotherapists (PABS.PT) and 6 vignettes (3 acute and 3 chronic LBP patients). We used Latent Profile Analysis (LPA) to categorize the chiropractors into clusters depending on their PABS.PT outcome, whereby the classes differed primarily on the biomedical score. We used linear, logistic, and mixed models to examine the associations between these clusters, and adherence to the recommendations of guidelines on: 1) diagnostic imaging use, and 2) management of LBP (i.e. advice on activity, treatment, return-to-work, and bedrest).
Results
The response rate of the Dutch and Belgian chiropractors was 61% (n=149/245) and 57% (n= 54/95), respectively. The majority of chiropractors scored midrange of the biomedical scale of the PABS.PT. Three clusters were identified using LPA: 1) high biomedical class (n=18), 2) mid biomedical class (n=117) and 3) low biomedical class (n=23).
Results from the vignettes suggest that chiropractors in the high biomedical class better adhere to diagnostic imaging guidelines and to LBP guidelines when it concerns advice on return-to-work and activity compared to the other two classes. However, no differences were identified between the classes for treatment of LBP. All chiropractors adhered to the guidelines’ recommendation on bedrest.
Conclusion
The high biomedical class demonstrated better overall adherence to the practice guidelines for the management of LBP and diagnostic imaging than the other classes. Due to the small numbers for the high and low biomedical classes, these results should be interpreted with caution.
Deep Learning Prediction of Renal Anomalies for Prenatal Ultrasound Diagnosis
Authors: Miguel Olivier X. , Kaczmarek Emily , Lee Inok , Ducharme Robin , Dingwall-Harvey Alysha L.J. , White Ruth Rennicks , Bonin Brigitte , Aviv Richard I. , Hawken Steven , Armour Christine M. , Dick Kevin , Walker Mark C. 
Published: July 2023

Abstract

Deep learning algorithms have demonstrated remarkable potential in clinical diagnostics, particularly in the field of medical imaging. In this study, we investigated the application of deep learning models in early detection of fetal kidney anomalies. To provide an enhanced interpretation of those models’ predictions, we proposed an adapted two-class representation and developed a multi-class model interpretation approach for problems with more than two labels and variable hierarchical grouping of labels. Additionally, we employed the explainable AI (XAI) visualization tools Grad-CAM and HiResCAM, to gain insights into model predictions and identify reasons for misclassifications. The study dataset consisted of 969 unique ultrasound images; 646 control images and 323 cases of kidney anomalies, including 259 cases of unilateral urinary tract dilation and 64 cases of unilateral multicystic dysplastic kidney. The best performing model achieved a cross-validated area under the ROC curve of 90.71% ± 0.54%, with an overall accuracy of 81.70% ± 0.88%, sensitivity of 81.20% ± 2.40% and specificity of 82.06% ± 1.74% on a test dataset. Our findings emphasize the potential of deep learning models in predicting kidney anomalies from limited prenatal ultrasound imagery. The proposed adaptations in model representation and interpretation represent a novel solution to multi-class prediction problems.
Adaptation and application of the Fuzzy Synthetic Evaluation (FSE) method for characterizing the trophic state of tropical semiarid reservoirs
Authors: Raulino João B. S. , Neto Iran E. Lima 
Published: July 2023

Abstract
Eutrophication is a recurrent problem in water bodies, especially in tropical semiarid reservoirs. The Trophic State Index (TSI) is an important tool for the environmental management of aquatic systems. However, determining the TSI involves uncertainties that can affect decision making. This study aimed to adapt and apply the Fuzzy Synthetic Evaluation (FSE) to characterize the TSI considering the uncertainties of the reference eutrophication classification system. The Castanhão reservoir, the largest in the State of Ceará, Brazil, was taken as a case study. The results showed that: i) the uncertainty of the trophic classification system can be characterized by the triangular and trapezoidal membership functions; ii) the result matrix associates the global trophic level with a degree of certainty, providing greater confidence to the decision maker; iii) the eutrophication index (EI) is not an adequate tool for hierarchizing the trophic degree; and iv) the membership level of the global trophic state generated by the FSE method is a suitable alternative to the EI. It is concluded that the proposed FSE model can be a useful tool for improving water resources management, especially in drylands.
Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study
Authors: Park Seon Mee , Kim Ki Bae , Han Joung-Ho , Kim Nayoung , Kang Tae Uk , Swan Heather , Kim Hyun Jung 
Published: July 2023

Abstract
We aimed to evaluate the incidence and risk of PC in pancreatitis. We identified patients with acute pancreatitis (AP) (n = 225,811, 50.0%) and chronic pancreatitis (CP) (n = 225,685, 50.0%) from Korean population-based data and matched them with age- and sex-matched controls (n = 4,514,960). We analyzed the incidence and adjusted hazard ratios (aHRs) of PC among patients followed for more than 2 years or 5 years, and assessed risk changes over time in single episode of AP (SAP), recurrent AP (RAP), CP with AP, and CP without AP groups. We also performed subgroup analysis for both sexes. The incidences (per 104 person-years) and risks (aHR) of PC were higher in the RAP (12.69, 5.00) or CP with AP (12.12, 5.74) groups compared to the SAP (2.31, 1.32) or CP without AP (2.28, 1.57) groups. The risks of PC decreased over time, however, the risk of PC remained elevated in the RAP and CP with AP groups for more than 8 years. Females with RAP, SAP, and CP with AP had higher risks of PC than males. The risk of PC is higher and persists for longer duration in patients with RAP and CP with AP compared to those with SAP or CP without AP.
Study on flow field and convective heat transfer characteristics in grinding zone of large spiral angle flow disturbance grooved wheel
Authors: Mao Mingzhe , Liu Shibo , Jiang Jing Liang , Sun Shufeng , Wang Dexiang 
Published: July 2023

Abstract
In view of the high specific removal energy, high heat generation rate, low heat transfer efficiency, easy to produce local high temperature and grinding burns, new macro-structured grinding wheel forms were proposed, namely, Large Spiral-angle Grooved Grinding Wheels (LSG-GW, β > 85°) and Large Spiral-angle flow Disturbance Grooved Wheels (LSDG-GW). Considering the influence of wheel parameters, groove parameters and process parameters, an analytical model of the airflow field in the wedge area and contact area of LSG-GW was established. Analytical model of gas-liquid two-phase flow field and theoretical model of convective heat transfer coefficient distribution in heat transfer channels were established. The results showed that increasing the groove width, groove depth and the spiral angle can reduce the pressure of the flow field in the air barrier layer and make it easier for the grinding fluid to enter the grinding contact area. The LSDG-GW further reduces the grinding fluid back flow and side flow intensity, proving that the flow disturbance structure can bring in more grinding fluid into the grinding contact area. A theoretical model for the distribution of convective heat transfer coefficient in the grinding contact area was derived, and the analysis results proved that the flow disturbance structure can significantly improve the convective heat transfer coefficient in the grinding contact area. The LSDG-GW, as a new macro surface structured grinding wheel, has a very promising application in the high efficiency and high precision grinding process of difficult-to-machine alloy materials.
The Influence of Gleason score ≤6 histology on the outcome of high-risk localized prostate cancer after modern radiotherapy
Authors: Yamazaki Hideya , Suzuki Gen , Masui Koji , Aibe Norihiro , Kimoto Takuya , Yamada Kei , Okihara Koji , Hongo Fumiya , Okumi Masayoshi , Shiraishi Takumi , Fujihara Atsuko , Yoshida Ken , Nakamura Satoaki , Kato Takashi , Hashimoto Yasutoshi , Okabe Haruumi 
Published: July 2023

Abstract
Background We aimed to retrospectively review outcomes in patients with high-risk prostate cancer and a Gleason score ≤ 6 following modern radiotherapy.Materials and Methods We analyzed the outcomes of 1,374 patients who had undergone modern radiotherapy, comprising a high-risk low grade [HRLG] group (Gleason score ≤ 6; n = 99) and a high-risk high grade [HRHG] group (Gleason score ≥ 7, n = 1,275). We included 955 patients who received brachytherapy with or without external beam radio-therapy (EBRT) and 419 who received modern EBRT (intensity modulated radiotherapy [IMRT] or stereotactic body radiotherapy [SBRT]).Results At a median follow-up of 61 (2–177) months, actuarial 5-year biochemical failure-free survival rates were 95.6% and 90.9% (p = 0.0244), respectively. The HRLG group showed fewer clinical failure frequencies than the HRHG group (0% vs 4.9%, p = 0.04) and a better 5-year distant metastasis-free survival rate than the HRHG group (100% vs 96.4%, p = 0.039).Conclusions As the HRLG group exhibited no clinical failure and better outcomes than the HRHG group, the HRLG group might potentially be classified as a lower-risk group.
Alternate wetting and drying water management can reduce phosphorus availability under lowland rice cultivation irrespective of nitrogen level
Authors: Adhikary Partha Pratim , Mohanty Sheelabhadra , Rautaray Sachin Kanta , Manikandan Narayanan , Mishra Atmaram 
Published: July 2023

Abstract
The limited availability of phosphorus (P) in the soil, which is affected by soil moisture, has a significant impact on crop production. However, we still don't fully understand how water management and nitrogen addition affect the availability of phosphorus in paddy soil. An evaluation of the effects of two water management strategies that is continuous flooding (CF) and alternate wetting and drying (AWD) irrigation along with various nitrogenous fertiliser addition rates (equivalent to 0, 100%, 133%, and 166% recommended dose of N addition) on P availability in paddy soil took place over the course of a two-year field experiment. The results showed that water management had a significant influence on ferrous iron, microbial biomass P, and soil available P. However, the addition of nitrogen did not affect the availability of P in the soil. When nitrogen was added at various rates, AWD consistently reduced the amount of soil-available P compared to CF. This was primarily because AWD increased microbial biomass, which immobilized phosphorus and decreased the content of ferrous iron. As a result, the soil's ability to absorb phosphorus increased, leading to a decrease in the amount of phosphorus available. In conclusion, AWD decreases the amount of available P in paddy soil compared to CF.