bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS EFEKTIVITAS PERAWATAN MESIN PEMBANGKIT PADA PLTD SANANA DENGAN MENGGUNAKAN METODE OVERALL EQUIPMENT EFFECTIVENESS (OEE) DAN OVERALL RESOURCE EFFECTIVENESS (ORE)
Authors: Umasugi Mega Cahyuni , Tukan Marcus , Pattiapon Marcy L. 
Published: March 2023

Dalam mengoperasikan tenaga listrik terdapat berbagai permasalahan antara lain pemakaian karena tenaga listrik selalu berubah dari waktu kewaktu, gangguan jaringan, kondisi alam dan lingkungan. Hal tersebut menyebabkan terjadinya downtime. Downtime merupakan waktu ketika mesin tidak dapat beroperasi dalam jangka waktu tertentu. Downtime yang terjadi mengakibatkan pemadaman listrik selama mesin dalam perbaikan dan berdampak pada produktivitas mesin. Produktivitas yang baik dapat dilihat dari kinerja mesin yang baik pula. Hal ini dapat ditandai dengan tingginya nilai efektivitas mesin. Tujuan dari penelitian ini untuk mengetahui efektivitas mesin dengan mengunakan metode Overall Equipment Effectiveness (OEE) dan Overall Resource Effectiveness (ORE). Hasil penelitian menunjukkan bahwa, rata-rata nilai OEE sebesar 52.05% dan nilai ORE sebesar 51.91%. Kedua nilai efektivitas mesin ini berada dibawah standar JIPM (Japan Institute of Plant Maintenance) yaitu 85%. Rendahnya nilai OEE dan ORE lebih dominan disebabkan oleh faktor performance effeciency.
Opposed evolution of the osseous and soft parts of progestin-associated osteomeningioma after progestin intake discontinuation
Authors: Florea Simona M. , Passeri Thibault , Abbritti Rosaria , Bernat Anne L. , Fontanel Sylvie , Yoldjian Isabelle , Funck-Brentano Thomas , Weill Alain , Mandonnet Emmanuel , Froelich Sébastien 
Published: March 2023

OBJECTIVE
Numerous studies have confirmed a strong association between progestins and meningiomas and the regression and/or stabilization of meningiomas after discontinuation of treatment. Osteomeningiomas represent a small subgroup of meningiomas that appear to be more common among progestin-related meningiomas. However, the specificity of the behavior of this subset of meningiomas after discontinuation of progestin has not yet been assessed.

METHODS
Thirty-six patients (mean age 49.5 years) who presented with at least one progestin-related osteomeningioma (48 tumors total) were identified from a prospectively collected database of patients and had been referred to our department for meningioma and had documented use of cyproterone acetate, nomegestrol acetate, and/or chlormadinone acetate. Hormonal treatment was stopped at the time of diagnosis for all the patients, and the clinical and radiological evolution of this subgroup of tumors was evaluated.

RESULTS
For half of the 36 patients, treatment was prescribed for signs of hyperandrogenism, such as hirsutism, alopecia, or acne. Most lesions were spheno-orbital (35.4%) or frontal (31.2%). Although the tissular part of the meningioma shrank in 77.1% of cases, the osseous part exhibited discordant behavior with 81.3% showing volume progression. The combination of estrogens, as well as the prolonged duration of progestin treatment, seems to increase the risk of progression of the osseous part after treatment discontinuation (p = 0.02 and p = 0.028, respectively). No patient required surgical treatment at diagnosis or during the study.

CONCLUSIONS
These results show that while the soft intracranial part of progestin-related osteomeningioma tumor is the most likely to regress after treatment discontinuation, the bony part is more likely to increase in volume. These findings suggest the need for careful follow-up of these patients, especially those with tumors near the optical apparatus.
BOLD frequency–dependent alterations in resting-state functional connectivity by pallidal deep brain stimulation in patients with Parkinson’s disease
Authors: Li Zhenghao , Lai Yijie , Li Jun , He Naying , Li Dianyou , Yan Fuhua , Zhang Yuyao , Zhang Chencheng , Sun Bomin , Wei Hongjiang 
Published: March 2023

OBJECTIVE
Functional MRI (fMRI) has been used to investigate the therapeutic mechanisms underlying deep brain stimulation (DBS) for Parkinson’s disease (PD). However, the alterations in stimulation site–seeded functional connectivity induced by DBS at the internal globus pallidus (GPi) remain unclear. Furthermore, whether DBS-modulated functional connectivity is differentially affected within particular frequency bands remains unknown. The present study aimed to reveal the alterations in stimulation site–seeded functional connectivity induced by GPi-DBS and to examine whether there exists a frequency band effect in blood oxygen level–dependent (BOLD) signals related to DBS.

METHODS
Patients with PD receiving GPi-DBS (n = 28) were recruited for resting-state fMRI with DBS on and DBS off under a 1.5-T MR scanner. Age- and sex-matched healthy controls (n = 16) and DBS-naïve PD patients (n = 24) also received fMRI scanning. The alterations in stimulation site–seeded functional connectivity in the stimulation-on state versus stimulation-off state, as well as the relationship between alterations in connectivity and improvement in motor function induced by GPi-DBS, were examined. Furthermore, the modulatory effect of GPi-DBS on the BOLD signals within the 4 frequency subbands (slow-2 to slow-5) was investigated. Finally, the functional connectivity of the motor-related network, consisting of multiple cortical and subcortical regions, was also examined among the groups. In this study, p < 0.05 with Gaussian random field correction indicates statistical significance.

RESULTS
Functional connectivity seeding from the stimulation site (i.e., the volume of tissue activated [VTA]) increased in the cortical sensorimotor areas and decreased in the prefrontal regions with GPi-DBS. Alterations in connectivity between the VTA and the cortical motor areas were correlated with motor improvement by pallidal stimulation. The alterations in connectivity were dissociable between the frequency subbands in the occipital and cerebellar areas. The motor network analysis indicated decreased connectivity among most cortical and subcortical regions but increased connectivity between the motor thalamus and the cortical motor area in patients with GPi-DBS compared with those in DBS-naïve patients. The DBS-induced decrease in several cortical-subcortical connectivities within the slow-5 band correlated with motor improvement with GPi-DBS.

CONCLUSIONS
These findings indicate that the alterations in functional connectivity from the stimulation site to the cortical motor areas, as well as multiple connectivities among the motor-related network, were associated with the efficacy of GPi-DBS for PD. Furthermore, the changing pattern of functional connectivity within the 4 BOLD frequency subbands is partially dissociable.
Reappraisal of the anatomy of the frontotemporal branches of the facial nerve
Authors: Nunez Maximiliano Alberto , Mohyeldin Ahmed , Marotta Dario A. , Vigo Vera , Asmaro Karam , Xu Yuanzhi , Cohen-Gadol Aaron A. , Fernandez-Miranda Juan C. 
Published: March 2023

OBJECTIVE
The anatomy of the temporal branches of the facial nerve (FN) has been widely described in the neurosurgical literature because of its relevance in anterolateral approaches to the skull base and implication in frontalis palsies from these approaches. In this study, the authors attempted to describe the anatomy of the temporal branches of the FN and identify whether there are any FN branches that cross the interfascial space of the superficial and deep leaflets of the temporalis fascia.

METHODS
The surgical anatomy of the temporal branches of the FN was studied bilaterally in 5 embalmed heads (n = 10 extracranial FNs). Exquisite dissections were performed to preserve the relationships of the branches of the FN and their relationship to the surrounding fascia of the temporalis muscle, the interfascial fat pad, the surrounding nerve branches, and their final terminal endpoints near the frontalis and temporalis muscles. The authors correlated their findings intraoperatively with 6 consecutive patients with interfascial dissection in which neuromonitoring was performed to stimulate the FN and associated twigs that were observed to be interfascial in 2 of them.

RESULTS
The temporal branches of the FN stay predominantly superficial to the superficial leaflet of the temporal fascia in the loose areolar tissue near the superficial fat pad. As they course over the frontotemporal region, they give off a twig that anastomoses with the zygomaticotemporal branch of the trigeminal nerve, which crosses the superficial layer of the temporalis muscle, spanning the interfascial fat pad, and then pierces the deep temporalis fascial layer. This anatomy was observed in 10 of the 10 FNs dissected. Intraoperatively, stimulation of this interfascial segment yielded no facial muscle response up to 1 mA in any of the patients.

CONCLUSIONS
The temporal branch of the FN gives off a twig that anastomoses with the zygomaticotemporal nerve, which crosses the superficial and deep leaflets of the temporal fascia. Interfascial surgical techniques aimed at protecting the frontalis branch of the FN are safe in their efforts to protect against frontalis palsy with no clinical sequelae when executed properly.
Femoral access site complications following neurointerventional procedures: economic implications at a single center
Authors: Joshi Krishna C. , Khanna Ryan , Beer-Furlan André , McLaughlin Elizabeth , Chen Michael , Crowley R. Webster , Munich Stephan A. 
Published: March 2023

OBJECTIVE
Transfemoral access (TFA) has been the traditional route of arterial access for neurointerventional procedures. Femoral access site complications may occur in 2%–6% of patients. Management of these complications often requires additional diagnostic tests or interventions, each of which may increase the cost of care. The economic impact of a femoral access site complication has not yet been described. The objective of this study was to evaluate the economic consequences of femoral access site complications.

METHODS
The authors conducted a retrospective review of patients undergoing neuroendovascular procedures at their institute and identified those who experienced femoral access site complications. The subset of patients experiencing these complications during elective procedures was matched in a 1:2 fashion to a control group undergoing similar procedures and not experiencing an access site complication.

RESULTS
Femoral access site complications were identified in 77 patients (4.3%) over a 3-year period. Thirty-four of these complications were considered major, requiring blood transfusion or additional invasive treatment. There was a statistically significant difference in total cost ($39,234.84 vs $23,535.32, p = 0.001), total reimbursement ($35,500.24 vs $24,861.71, p = 0.020) and reimbursement minus cost (−$3734.60 vs $1326.39, p = 0.011) between the complication and control cohorts in elective procedures, respectively.

CONCLUSIONS
Although occurring relatively infrequently, femoral artery access site complications increase the cost of care for patients undergoing neurointerventional procedures; how this influences the cost effectiveness of neurointerventional procedures warrants further investigation.
Validation of an automated machine learning algorithm for the detection and analysis of cerebral aneurysms
Authors: Colasurdo Marco , Shalev Daphna , Robledo Ariadna , Vasandani Viren , Luna Zean Aaron , Rao Abhijit S. , Garcia Roberto , Edhayan Gautam , Srinivasan Visish M. , Sheth Sunil A. , Donner Yoni , Bibas Orin , Limzider Nicole , Shaltoni Hashem , Kan Peter 
Published: March 2023

OBJECTIVE
Machine learning algorithms have shown groundbreaking results in neuroimaging. The authors herein evaluated the performance of a newly developed convolutional neural network (CNN) to detect and analyze intracranial aneurysms (IAs) on CTA.

METHODS
Consecutive patients with CTA studies between January 2015 and July 2021 at a single center were identified. The ground truth determination of cerebral aneurysm presence or absence was made from the neuroradiology report. The primary outcome was the performance of the CNN in detecting IAs in an external validation set, measured using area under the receiver operating characteristic curve statistics. Secondary outcomes included accuracy for location and size measurement.

RESULTS
The independent validation imaging data set consisted of 400 patients with CTA studies, median age 40 years (IQR 34 years) and 141 (35.3%) of whom were male; 193 patients (48.3%) had a diagnosis of IA on neuroradiologist evaluation. The median maximum IA diameter was 3.7 mm (IQR 2.5 mm). In the independent validation imaging data set, the CNN performed well with 93.8% sensitivity (95% CI 0.87–0.98), 94.2% specificity (95% CI 0.90–0.97), and a positive predictive value of 88.2% (95% CI 0.80–0.94) in the subgroup with an IA diameter ≥ 4 mm.

CONCLUSIONS
The described Viz.ai Aneurysm CNN performed well in identifying the presence or absence of IAs in an independent validation imaging set. Further studies are necessary to investigate the impact of the software on detection rates in a real-world setting.
Endovascular treatment as first-line therapy in Spetzler-Martin grade III brain arteriovenous malformations: a multicenter retrospective study
Authors: Burel Julien , Papagiannaki Chrysanthi , Sourour Nader , Talbi Atika , Garnier Matthieu , Hermary Capucine , Talaat Maichael , Boch Anne-Laure , Nouet Aurélien , Lenck Stéphanie , Premat Kévin , Shotar Eimad , Clarençon Frédéric 
Published: March 2023

OBJECTIVE
The management of Spetzler-Martin grade (SMG) III brain arteriovenous malformations (bAVMs) may be challenging, whatever the exclusion treatment modality chosen. The purpose of this study was to evaluate the safety and effectiveness of endovascular treatment (EVT) as a first-line treatment of SMG III bAVMs.

METHODS
The authors performed a retrospective, two-center, observational cohort study. Cases recorded in institutional databases between January 1998 and June 2021 were reviewed. Patients who were ≥ 18 years of age, had ruptured or unruptured SMG III bAVMs, and received EVT as first-line therapy were included. Baseline characteristics of patients and bAVMs, procedure-related complications, clinical outcome according to the modified Rankin Scale, and angiographic follow-up were assessed. The independent risk factors of procedure-related complications and poor clinical outcome were assessed using binary logistic regression.

RESULTS
One hundred sixteen patients with 116 SMG III bAVMs were included. The mean age of the patients was 41.9 ± 14.0 years. The most common presentation was hemorrhage (66.4%). Forty-nine (42.2%) bAVMs were found to be completely obliterated by EVT alone at follow-up. Complications occurred in 39 patients (33.6%), including 5 (4.3%) major procedure-related complications. There was no independent predictor of procedure-related complication. Age > 40 years and poor preoperative modified Rankin Scale score were the independent predictors of poor clinical outcome.

CONCLUSIONS
EVT of SMG III bAVMs provides encouraging results but needs further improvement. When the embolization procedure performed with intent to cure appears difficult and/or risky, a combined technique (with microsurgery or radiosurgery) may be a safer and more effective strategy. In terms of safety and effectiveness, the benefit of EVT (alone or included in a multimodal management strategy) for SMG III bAVMs needs to be confirmed by randomized controlled trials.
Oscillation analysis as a supporting element toward safe and reliable lumbar catheter intracranial pressure monitoring
Authors: Früh Anton , Wolf Stefan , Wessels Lars , Vajkoczy Peter , Hecht Nils 
Published: March 2023

OBJECTIVE
Lumbar drainage of cerebrospinal fluid for treatment of refractory increased intracranial pressure (ICP) is associated with the risk of infratentorial herniation, but real-time biomarkers for signaling herniation at bedside are lacking. Here, the authors tested whether an alteration of pulsatile waveform conduction across the level of the foramen magnum could serve as an indicator of insufficient hydrostatic communication and impending herniation.

METHODS
This prospective observational cohort study included patients with severe acute brain injury who underwent continuous external ventricular drain monitoring of ICP and lumbar drain pressure monitoring. Continuous recordings of ICP, lumbar pressure (LP), and arterial blood pressure (ABP) were screened throughout a recording period of 4–10 days. Pressure differences between ICP and LP > 5 mm Hg for 5 minutes were defined as a Δ-event, implicating nonsufficient hydrostatic communication. During this period, oscillation analysis of the ICP, LP, and ABP waveforms was performed by determining the eigenfrequencies (EFs) and their amplitudes (AEF) via Fourier transformation scripted in Python.

RESULTS
Of 142 patients, 14 exhibited a Δ-event, with a median (range) ICP of 12.2 (10.7–18.8) mm Hg and LP of 5.6 (3.3–9.8) mm Hg during 2993 hours of recording time. The AEF ratio between ICP and LP (p < 0.01) and between ABP and LP (p = 0.032) increased significantly during Δ-events compared with the baseline values determined 3 hours prior to the event. The ratio between ICP and ABP remained unaffected.

CONCLUSIONS
Oscillation behavior analysis of LP and ABP waveforms during controlled lumbar drainage may serve as a personalized, simple, and effective biomarker to signal impending infratentorial herniation in real time without the need for simultaneous ICP monitoring.
Evaluation of lymphopenia as a predictor of postoperative mortality and major complications in patients undergoing surgery for metastatic spine tumors
Authors: Ryvlin Jessica , Hamad Mousa K. , Langro Justin , Wang Benjamin , Patel Pavan , De la Garza Ramos Rafael , Murthy Saikiran G. , Gelfand Yaroslav , Yassari Reza 
Published: March 2023

OBJECTIVE
Lymphopenia is often seen in advanced metastatic disease and has been associated with poor postoperative outcomes. Limited research has been done to validate this metric in patients with spinal metastases. The objective of this study was to evaluate the capability of preoperative lymphopenia to predict 30-day mortality, overall survival (OS), and major complications in patients undergoing surgery for metastatic spine tumors.

METHODS
A total of 153 patients who underwent surgery for metastatic spine tumor between 2012 and 2022 and met the inclusion criteria were examined. Electronic medical record chart review was conducted to obtain patient demographics, comorbidities, preoperative laboratory values, survival time, and postoperative complications. Preoperative lymphopenia was defined as < 1.0 K/μL based on the institution’s laboratory cutoff value and within 30 days prior to surgery. The primary outcome was 30-day mortality. Secondary outcomes were OS up to 2 years and 30-day postoperative major complications. Outcomes were assessed with logistic regression. Survival analyses were done using the Kaplan-Meier method with log-rank test and Cox regression. Receiver operating characteristic curves were plotted to classify the predictive ability of lymphocyte count as a continuous variable on outcome measures.

RESULTS
Lymphopenia was identified in 47% of patients (72 of 153). The overall 30-day mortality rate was 9% (13 of 153). In logistic regression analysis, lymphopenia was not associated with 30-day mortality (OR 1.35, 95% CI 0.43–4.21; p = 0.609). The mean OS in this sample was 15.6 months (95% CI 13.9–17.3 months), with no significant difference between patients with lymphopenia and those with no lymphopenia (p = 0.157). Cox regression analysis did not show an association between lymphopenia and survival (HR 1.44, 95% CI 0.87–2.39; p = 0.161). The major complication rate was 26% (39 of 153). In univariable logistic regression analysis, lymphopenia was not associated with the development of a major complication (OR 1.44, 95% CI 0.70–3.00; p = 0.326). Finally, receiver operating characteristic curves generated poor discrimination between lymphocyte count and all outcomes, including 30-day mortality (area under the curve 0.600, p = 0.232).

CONCLUSIONS
This study does not support prior research that had shown an independent association between low preoperative lymphocyte level and poor postoperative outcomes following surgery for metastatic spine tumors. Although lymphopenia may be used to predict outcomes in other tumor-related surgeries, this metric may not hold a similar predictive capability in the population undergoing surgery for metastatic spine tumors. Further research into reliable prognostic tools is needed.
Towards a formal ontology of engineering functions, behaviours, and capabilities
Authors: Compagno Francesco , Borgo Stefano 
Published: March 2023

In both applied ontology and engineering, functionality is a well-researched topic, since it is through teleological causal reasoning that domain experts build mental models of engineering systems, giving birth to functions. These mental models are important throughout the whole lifecycle of any product, being used from the design phase up to diagnosis activities. Though a vast amount of work to model functions has already been carried out, the literature has not settled on a shared and well-defined approach due to the variety of concepts involved and the modeling tasks that functional descriptions should satisfy. The work in this paper posits the basis and makes some crucial steps towards a rich ontological description of functions and related concepts, such as behaviour, capability, and capacity. A conceptual analysis of such notions is carried out using the top-level ontology DOLCE as a framework, and the ensuing logical theory is formally described in first-order logic and OWL, showing how ontological concepts can model major aspects of engineering products in applications. In particular, it is shown how functions can be distinguished from the implementation methods to realize them, how one can differentiate between capabilities and capacities of a product, and how these are related to engineering functions.
Cobalt containing glass fibres and their synergistic effect on the HIF-1 pathway for wound healing applications
Authors: Solanki Anu K. , Autefage Hélène , Rodriguez Antonio R. , Agarwal Shweta , Penide Joaquin , Mahat Muzamir , Whittaker Thomas , Nommeots-Nomm Amy , Littmann Elena , Payne David J. , Metcalfe Anthony D. , Quintero Felix , Pou Juan , Stevens Molly M. , Jones Julian R. 
Published: March 2023

Introduction and Methods: Chronic wounds are a major healthcare problem, but their healing may be improved by developing biomaterials which can stimulate angiogenesis, e.g. by activating the Hypoxia Inducible Factor (HIF) pathway. Here, novel glass fibres were produced by laser spinning. The hypothesis was that silicate glass fibres that deliver cobalt ions will activate the HIF pathway and promote the expression of angiogenic genes. The glass composition was designed to biodegrade and release ions, but not form a hydroxyapatite layer in body fluid.Results and Discussion: Dissolution studies demonstrated that hydroxyapatite did not form. When keratinocyte cells were exposed to conditioned media from the cobalt-containing glass fibres, significantly higher amounts of HIF-1α and Vascular Endothelial Growth Factor (VEGF) were measured compared to when the cells were exposed to media with equivalent amounts of cobalt chloride. This was attributed to a synergistic effect of the combination of cobalt and other therapeutic ions released from the glass. The effect was also much greater than the sum of HIF-1α and VEGF expression when the cells were cultured with cobalt ions and with dissolution products from the Co-free glass, and was proven to not be due to a rise in pH. The ability of the glass fibres to activate the HIF-1 pathway and promote VEGF expression shows the potential for their use in chronic wound dressings.