bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of immune‐related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma
Authors: Tsukamoto Yoshiyuki , Kurogi Shusaku , Fujishima Hajime , Shibata Tomotaka , Fumoto Shoichi , Nishiki Kohei , Suzuki Kosuke , Etoh Tsuyoshi , Shiraishi Norio , Fuchino Takafumi , Hirashita Yuka , Nakada Chisato , Uchida Tomohisa , Inomata Masafumi , Moriyama Masatsugu , Hijiya Naoki 
Published: September 2023

AbstractNeoadjuvant chemotherapy (NAC) followed by surgery is one of the standard therapeutic approaches in Japan for patients with locally advanced esophageal carcinoma. Recently, the JCOG1109 study revealed that NAC with docetaxel, cisplatin and 5‐fluorouracil (5‐FU) (DCF‐NAC) is superior to NAC with cisplatin and 5‐FU, and has now become the standard preoperative chemotherapy. Using a microarray system, we have previously investigated the expression profiles of endoscopic biopsy samples from patients with esophageal squamous cell carcinoma (ESCC) before DCF‐NAC (preNAC) and identified 17 molecules as biomarkers predictive of a pathologically complete response to DCF‐NAC. Here, we re‐grouped our previous dataset based on the histopathological response grade with the addition of several microarray profiles and conducted a re‐analysis using bioinformatic web tools including DAVID, GSEA, UALCAN, and CIBERSORTx. We identified 204 genes that were differentially expressed between the highly resistant and sensitive groups. Some of these differentially expressed genes (DEGs) were related to the immune response and showed higher expression in the sensitive group. UALCAN showed that high expression of 28 of the top 50 DEGs was associated with a favorable prognosis (p < 0.25), and that this reached a significant (p < 0.05) level for 18 of them, suggesting that patients with high expression of these genes might have benefited from chemotherapy and thus had a better outcome. In preNAC biopsy tissues from a DCF‐sensitive case, we demonstrated the presence of cells expressing mRNA for CXCL9, one of the prognosis‐related DEGs. Our results highlight the association of immune‐related expression profile in preNAC ESCC with the DCF‐NAC efficacy.
Potentiated GABAergic neuronal activities in the basolateral amygdala alleviate stress‐induced depressive behaviors
Authors: Asim Muhammad , Wang Huajie , Chen Xi , He Jufang 
Published: September 2023

AbstractAimsMajor depressive disorder is a severe psychiatric disorder that afflicts ~17% of the world population. Neuroimaging investigations of depressed patients have consistently reported the dysfunction of the basolateral amygdala in the pathophysiology of depression. However, how the BLA and related circuits are implicated in the pathogenesis of depression is poorly understood.MethodsHere, we combined fiber photometry, immediate early gene expression (c‐fos), optogenetics, chemogenetics, behavioral analysis, and viral tracing techniques to provide multiple lines of evidence of how the BLA neurons mediate depressive‐like behavior.ResultsWe demonstrated that the aversive stimuli elevated the neuronal activity of the excitatory BLA neurons (BLACAMKII neurons). Optogenetic activation of CAMKII neurons facilitates the induction of depressive‐like behavior while inhibition of these neurons alleviates the depressive‐like behavior. Next, we found that the chemogenetic inhibition of GABAergic neurons in the BLA (BLAGABA) increased the firing frequency of CAMKII neurons and mediates the depressive‐like phenotypes. Finally, through fiber photometry recording and chemogenetic manipulation, we proved that the activation of BLAGABA neurons inhibits BLACAMKII neuronal activity and alleviates depressive‐like behavior in the mice.ConclusionThus, through evaluating BLAGABA and BLACAMKII neurons by distinct interaction, the BLA regulates depressive‐like behavior.
Luteolin alleviates depression‐like behavior by modulating glycerophospholipid metabolism in the hippocampus and prefrontal cortex of LOD rats
Authors: Wu Xiaofeng , Xu Hanfang , Zeng Ningxi , Li Huizhen , Yao Gaolei , Liu Kaige , Yan Can , Wu Lili 
Published: September 2023

AbstractBackgroundLate‐onset depression (LOD) is defined as primary depression that first manifests after the age of 65. Luteolin (LUT) is a natural flavonoid that has shown promising antidepressant effects and improvement in neurological function in previous studies.AimsIn this study, we utilized UPLC–MS/MS non‐targeted metabolomics techniques, along with molecular docking technology and experimental validation, to explore the mechanism of LUT in treating LOD from a metabolomics perspective.ResultsThe behavioral results of our study demonstrate that LUT significantly ameliorated anxiety and depression‐like behaviors while enhancing cognitive function in LOD rats. Metabolomic analysis revealed that the effects of LUT on LOD rats were primarily mediated through the glycerophospholipid metabolic pathway in the hippocampus and prefrontal cortex. The levels of key lipid metabolites, phosphatidylserine (PS), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), in the glycerophospholipid metabolic pathway were significantly altered by LUT treatment, with PC and PE showing significant correlations with behavioral indices. Molecular docking analysis indicated that LUT had strong binding activity with phosphatidylserine synthase 1 (PTDSS1), phosphatidylserine synthase 2 (PTDSS2), and phosphatidylserine decarboxylase (PISD), which are involved in the transformation and synthesis of PC, PE, and PS. Lastly, our study explored the reasons for the opposing trends of PC, PE, and PS in the hippocampus and prefrontal cortex from the perspective of autophagy, which may be attributable to the bidirectional regulation of autophagy in distinct brain regions.ConclusionsOur results revealed significant alterations in the glycerophospholipid metabolism pathways in both the hippocampus and prefrontal cortex of LOD rats. Moreover, LUT appears to regulate autophagy disorders by specifically modulating glycerophospholipid metabolism in different brain regions of LOD rats, consequently alleviating depression‐like behavior in these animals.
Postoperative use of steroids for peri‐electrode edema after deep brain stimulation surgery: A retrospective cohort study
Authors: Wu Bin , Ling Yuting , Zhang Changming , Xu Jiakun , Yang Chao , Jiang Nan , Chen Ling , Liu Jinlong 
Published: September 2023

AbstractBackgroundTo review the incidence and extent of peri‐electrode edema after DBS and to clarify the effect of postoperative use of steroids on the peri‐electrode edema.MethodsThis retrospective cohort study included 250 patients who underwent bilateral subthalamic nucleus (STN) DBS surgery with intact MRI within 1 month after DBS surgery. Patients were divided into steroid and non‐steroid groups, based on postoperative steroids use. The occurrence and extent of peri‐electrode edema were compared between the two groups, and other associated factors were analyzed using univariate and multivariate methods.ResultsPeri‐electrode edema >1 cm3 in at least one hemisphere was reported in 215 (86.00%) patients. The mean volume of peri‐electrode edema observed in the steroid group was significantly smaller than in the non‐steroid group (8.09 ± 8.47 cm3 vs 17.10 ± 16.90 cm3, p < 0.001). In the steroid group, 104 (32.91%) of the 316 implanted electrodes present with edema less than 1 cm3, whereas in the non‐steroid group, only 27 (14.67%) of the 184 implanted electrodes present with edema less than 1 cm3 (p < 0.001). Multivariate analysis indicated that lesser peri‐electrode edema was significantly associated with postoperative steroids use and general anesthesia.ConclusionsPeri‐electrode edema is common after DBS surgery, and postoperative steroids use reduces the occurrence and extent of peri‐electrode edema.
An Agent‐First Preference in a Patient‐First Language During Sentence Comprehension
Authors: Sauppe Sebastian , Næss Åshild , Roversi Giovanni , Meyer Martin , Bornkessel‐Schlesewsky Ina , Bickel Balthasar 
Published: September 2023

AbstractThe language comprehension system preferentially assumes that agents come first during incremental processing. While this might reflect a biologically fixed bias, shared with other domains and other species, the evidence is limited to languages that place agents first, and so the bias could also be learned from usage frequency. Here, we probe the bias with electroencephalography (EEG) in Äiwoo, a language that by default places patients first, but where sentence‐initial nouns are still locally ambiguous between patient or agent roles. Comprehenders transiently interpreted nonhuman nouns as patients, eliciting a negativity when disambiguation was toward the less common agent‐initial order. By contrast and against frequencies, human nouns were transiently interpreted as agents, eliciting an N400‐like negativity when the disambiguation was toward patient‐initial order. Consistent with the notion of a fixed property, the agent bias is robust against usage frequency for human referents. However, this bias can be reversed by frequency experience for nonhuman referents.
Disparities in telemedicine utilization among kidney transplant patients during the COVID‐19 pandemic: Barriers and opportunities
Authors: Forbes Rachel C. , Johnson Wali R. , D'Souza Nigel , Dreher Anthony , Rega Scott A. , Feurer Irene D. , Concepcion Beatrice P. 
Published: September 2023

AbstractIntroductionThe COVID‐19 pandemic allowed for the rapid implementation of telemedicine for kidney transplant patients; however, widespread adoption may worsen existing health care inequities among vulnerable populations. This study aimed to characterize telemedicine utilization by kidney transplant patients during the early pandemic with particular attention to healthcare equity.MethodsA retrospective analysis of kidney transplant patients interacting with telemedicine was performed. Patient demographic data and distance to the transplant center were obtained. The National Center for Health Statistics (NCHS) Urban‐Rural Classification Scheme for Counties and Brokamp Neighborhood Deprivation Index (NDI) score were used to characterize patients’ counties of residence. Multivariable logistic regression evaluated associations between patient and community characteristics and the likelihood of an encounter being telemedicine.ResultsThis study included 1033 patients who participated in 3727 encounters from March 11 through October 2020. Characteristics associated with decreased likelihood of telemedicine use were increased age (OR = .993; 95% CI = .986‐.999, P = .022), non‐White vs. White race (OR = .826, 95% CI = .697‐.979; P = .028), male vs. female sex (OR = .746, 95% CI = .632‐.880; P < .001), and a higher Brokamp Neighborhood Deprivation Index score (OR = .159; 95% CI = .029‐.873; P = .034). The effect of distance to the transplant center on the likelihood of a telemedicine encounter differed by NCHS Urban‐Rural designation (interaction P = .018), with its likelihood increasing by 2%–3% with each 10‐mile increment among persons residing in medium‐, small‐, and non‐metropolitan counties compared to those residing in the most rural counties.ConclusionsTelemedicine visits were less often completed by patients of older age, non‐white race, male sex, and those residing in counties having higher NDI scores. While telemedicine has the potential to improve healthcare access and decrease costs, proactive efforts need to be taken to mitigate disparities in vulnerable populations.
Spinal and bulbar muscular atrophy combined with hypertrophic cardiomyopathy and Brugada‐pattern electrocardiographic changes: A case report
Authors: Liu Tian , Weng Haoyu , Ding Wenhui , Chu Xujun , Li Jianping 
Published: September 2023

AbstractSpinal and bulbar muscular atrophy (SBMA) is a rare X‐linked recessive neurodegenerative disorder caused by the excessive expansion of cytosine‐adenine‐guanine repeat sequences in the androgen receptor gene encoded on the Xq11‐12 chromosome. SBMA primarily affects adult males and is characterized by weakness and atrophy of the proximal limb muscles, often involving the bulbar muscles. In addition to neuromuscular deficits, nonneuronal symptoms such as hypertension, hyperlipidemia, and liver dysfunction are often observed in patients with SBMA. Previous studies have suggested that SBMA patients have been diagnosed with hypertrophic cardiomyopathy (HCM), while gene detection is lacked. Moreover, according to current reports, SBMA patients can carry Brugada syndrome or HCM respectively, while three kinds of diseases have not been reported to exist in the same patient. Here, we report the first case of a male diagnosed with SBMA combined with HCM and two types of Brugada‐pattern electrocardiographic changes, with a heterozygous missense mutation in the TTN gene.
Mechanisms and implications of mitral regurgitation in patients with severe aortic stenosis who received transcatheter aortic valve replacement
Authors: Horinouchi Hitomi , Nagai Tomoo , Ohno Yohei , Miyamoto Junichi , Kamioka Norihiko , Murakami Tsutomu , Yoshioka Koichiro , Ikari Yuji 
Published: September 2023

AbstractIntroductionThis study aimed to investigate the mechanisms and clinical implications of mitral regurgitation (MR) in patients with severe aortic stenosis (AS) who received transcatheter aortic valve replacement (TAVR).MethodsWe conducted retrospective echocardiographic analyses at baseline and 6 months after TAVR in 140 patients with symptomatic AS (85 ± 5 years) who underwent TAVR. We defined significant MR as ≥ moderate based on evaluation of transthoracic echocardiography (TTE).ResultsThere were 48 patients (34%) with preexisting MR at the baseline. Among measured TTE parameters, end‐systolic wall stress (ESWS), mitral annulus area, and mitral valve thickening index were independent factors associated with preexisting MR (odds ratio [OR]: 1.013, 95% confidence interval [CI]: 1.005–1.021; OR: 1.740, 95% CI: 1.314–2.376; OR: 2.306, 95% CI: 1.426–3.848; respectively). Six months after TAVR, there were 34 patients with post‐existing MR, A history of atrial fibrillation and ESWS after TAVR were independent factors (OR: 3.013, 95% CI: 1.208–7.556; OR: 1.013, 95% CI: 1.000–1.023; respectively). The Kaplan–Meier plot indicated that preexisting MR was a risk factor for heart failure–related events within 1 year of discharge after TAVR (p = .012).ConclusionsIn patients who underwent TAVR for severe AS, preexisting MR was associated with having a thickened mitral valve and large mitral annulus size induced by high ESWS. These patients may have worse prognosis after TAVR and should be closely monitored in the long term.
Flight and flight energy accumulation related to the daily rhythm of juvenile hormone titer in the wing‐dimorphic cricket Velarifictorus aspersus
Authors: Pang Yin , Zeng Yang , Zhu Dao‐Hong 
Published: September 2023

AbstractThe cricket Velarifictorus aspersus (Walker) (Orthoptera: Gryllidae) exhibits a wing dimorphism mediating two distinct life‐history strategies during early adulthood; long‐winged (LW) females mainly invest resources in flight, whereas short‐winged (SW) females invest more heavily in reproduction than LW females. To understand the relationships among juvenile hormone (JH), flight capacity, and energy accumulation, the daily rhythm of JH titer and flight activity, the concentrations of flight energy substances, and the influence of exogenous JH on flight activity and flight energy substances were investigated in V. aspersus. The results showed that the hemolymph JH titer exhibited a high‐amplitude daily rhythm in 5‐day‐old LW V. aspersus females, and the JH titer rose about 10× at 18:00 hours (6 h before lights off) and dropped to baseline levels after lights off. The females flew inactively (i.e., they floated in the air) from 14:00 to 19:00 hours during the light period, whereas they had a stronger flight capacity in the initial photophase and before lights out. The flight ability of LW females with 20 μg μL−1 JH treatments was significantly improved during periods of flight inactivity. After the peak JH titer, the concentrations of glycogen and trehalose in the flight muscles increased significantly. The LW females treated with JH during the inactive flight period had a significant increase in glycogen after 1 h and trehalose after 3 h. These results suggested that the high‐amplitude daily rhythm of the JH titer was correlated with accumulation of flight energy substance and flight capacity; that is, an elevated JH titer promoted the biosynthesis of flight energy substances, resulting in improvement of flight capacity.
Artificial intelligence‐enhanced epileptic seizure detection by wearables
Authors: Yu Shuang , El Atrache Rima , Tang Jianbin , Jackson Michele , Makarucha Adam , Cantley Sarah , Sheehan Theodore , Vieluf Solveig , Zhang Bo , Rogers Jeffrey L. , Mareels Iven , Harrer Stefan , Loddenkemper Tobias 
Published: September 2023

AbstractObjectiveWrist‐ or ankle‐worn devices are less intrusive than the widely used electroencephalographic (EEG) systems for monitoring epileptic seizures. Using custom‐developed deep‐learning seizure detection models, we demonstrate the detection of a broad range of seizure types by wearable signals.MethodsPatients admitted to the epilepsy monitoring unit were enrolled and asked to wear wearable sensors on either wrists or ankles. We collected patients' electrodermal activity, accelerometry (ACC), and photoplethysmography, from which blood volume pulse (BVP) is derived. Board‐certified epileptologists determined seizure onset, offset, and types using video and EEG recordings per the International League Against Epilepsy 2017 classification. We applied three neural network models—a convolutional neural network (CNN) and a CNN–long short‐term memory (LSTM)‐based generalized detection model and an autoencoder‐based personalized detection model—to the raw time‐series sensor data to detect seizures and utilized performance measures, including sensitivity, false positive rate (the number of false alarms divided by the total number of nonseizure segments), number of false alarms per day, and detection delay. We applied a 10‐fold patientwise cross‐validation scheme to the multisignal biosensor data and evaluated model performance on 28 seizure types.ResultsWe analyzed 166 patients (47.6% female, median age = 10.0 years) and 900 seizures (13 254 h of sensor data) for 28 seizure types. With a CNN‐LSTM‐based seizure detection model, ACC, BVP, and their fusion performed better than chance; ACC and BVP data fusion reached the best detection performance of 83.9% sensitivity and 35.3% false positive rate. Nineteen of 28 seizure types could be detected by at least one data modality with area under receiver operating characteristic curve > .8 performance.SignificanceResults from this in‐hospital study contribute to a paradigm shift in epilepsy care that entails noninvasive seizure detection, provides time‐sensitive and accurate data on additional clinical seizure types, and proposes a novel combination of an out‐of‐the‐box monitoring algorithm with an individualized person‐oriented seizure detection approach.
Integrating perennial biomass crops into crop rotations: How to remove miscanthus and switchgrass without glyphosate
Authors: Lewin Eva , Kiesel Andreas , Magenau Elena , Lewandowski Iris 
Published: September 2023

AbstractPerennial energy grasses have gained attention in recent years as a promising resource for the bioeconomy because of their benign environmental profile, high stress tolerance, high biomass yields and low input requirements. Currently, strong breeding efforts are being made to extend the range of commercially available miscanthus and switchgrass genotypes. In order to foster farmers' acceptance of these crops, and especially of novel hybrids, more information is required about how they can be efficiently integrated into cropping rotations, how they can be removed at the end of their productive lifespan, and what effect they have on subsequently grown crops. Farmers in Europe are meanwhile increasingly constrained in the methods available to them to remove these crops, and there is a risk that the herbicide glyphosate, which has been used in many studies to remove them, will be banned in coming years. This study looks at the removal of seven‐year‐old stands of miscanthus and switchgrass over 1 year at an experimental site in Southern‐Germany. Three novel miscanthus genotypes were studied, alongside one variety of switchgrass, and the impact of each crop's removal on the yield of maize grown as a follow‐on crop was examined. A combination of soil tillage and grass herbicides for maize cultivation was successful in controlling miscanthus regrowth, such that yields of maize grown after miscanthus did not differ significantly from yields of maize grown in monoculture rotation (18.1 t dry biomass ha−1). Yields of maize grown after switchgrass (14.4 t dry biomass ha−1) were significantly lower than maize in monoculture rotation caused by insufficient control of switchgrass regrowth by the applied maize herbicide. Although some regrowth of miscanthus and switchgrass was observed in the follow‐on crop maize, complete eradication of both crops was achieved by subsequent winter wheat cultivation.
What's Gained from Depression? A Proposal on Theodicy and Epinosic Gains
Authors: Coblentz Jessica 
Published: September 2023

AbstractAbstract: Many depression‐sufferers testify to experiences of goodness that arise from their depression, or ‘goodness because of depression’. These realities often inspire efforts to reconcile suffering and divine benevolence. Yet some sufferers who experience ‘goodness because of depression’ reject theodical thinking and therefore seek other frameworks for reflection on their suffering and its accompanying goods. This essay draws from psychology's notion of epinosic gains to propose an analogous framework that aids sufferers in discussing and interpreting instances of ‘goodness because of depression’ apart from theodical justifications. While the proposed framework is grounded in first‐person reflections on depression and is articulated in relation to another Christian framework for depression from Tasia Scrutton, this constructive proposal has the potential to serve theological reflection on a wider range of suffering beyond depression.
Shared decision making with frail people with intellectual disabilities in the palliative phase: A process evaluation of the use of the In‐Dialogue conversation aid in practice
Authors: Noorlandt H. W. , Korfage I. J. , Felet F. M. A. J. , Aarts K. , Festen D. A. M. , Vrijmoeth C. , Van Der Heide A. , Echteld M. A. 
Published: September 2023

AbstractBackgroundThis study reports the process evaluation of the In‐Dialogue conversation aid to facilitate shared decision‐making with people with intellectual disabilities in the palliative phase.MethodsTraining for In‐Dialogue was evaluated by 53 support staff members through questionnaires. The use of In‐Dialogue in four residential care facilities for frail people with mild to severe intellectual disabilities was evaluated with semi‐structured interviews with five relatives, nine support staff and three people with intellectual disabilities.ResultsMost participants considered the training helpful to apply shared decision‐making. Sixty‐three people with intellectual disabilities participated in In‐Dialogue conversations. Almost all interviewees stated that these conversations provided additional insight into people's concerns and preferences. Involvement of people with profound intellectual disabilities and their relatives appeared to be challenging.ConclusionConversations about illness and the end of life appeared to be feasible with the In‐Dialogue conversation aid and provided insight into people's experiences and preferences.