bluuebunny/crossref_metadata_2025_split huggingface dataset:
KHAZANAH EKOLEKSIKON FLORA DAN FAUNA DALAM BOEKOE PANTOEN KARYA THE TIM LAM
Authors: Nurzuha Nurzuha , Fauzi Mohd , Iskandar Denni 
Published: August 2023

This research began with the phenomenon of the endangered language found in the pantun script which contains a lot of richness in the elements of the flora and fauna lexicon. The purpose of this study is to determine the richness of the flora and fauna lexicon and its meaning in Boekoe Pantoen by The Tim Lam. This kind of research is qualitative research in which this research uses the ecolinguistic concept of Aron Meko Mbete. The data of this research is in the form of flora and fauna eco-collection that sourced from Boekoe Pantoen by The Tim Lam. The results showed that there were 73 flora lexicon and 69 fauna lexicon. In the meaning of flora and fauna there is a social meaning, the meaning of love for the environment and culture. Basically people in ancient times were sympathetic to the environment, this nature became their inspiration material to express feelings using flora and fauna features, being grateful for God's favors, as medicine, entertainment, and these flora and fauna features do exist and are not just an illusion but are nowadays the phenomenon has changed. The flora and fauna lexicon is rarely used.
Analisis Kecelakaan Kapal Gili Cat II
Authors: Fauzika Maurisa Rohmah Amanda , Zudhan Aprisya Haafizhu , Setiaji Bayu 
Published: August 2023

Abstrak
Tujuan dari penelitian ini adalah untuk mengetahui berapakah kecepatan yang dianjurkan untuk mengendarai Kapal Gili Cat II dan apa yang terjadi ketika Kapal Gili Cat II dikendarai dengan kecepatan atau laju di atas batas yang dianjurkan serta mengetahui massa maximum yang dapat dibawa oleh Kapal Gili Cat II dan mengetahui hubungan dari massa terhadap kecepatan kapal. Metode yang digunakan dalam penelitian adalah metode kualitatif dokumen. Hasil dari studi kasus yang telah dilakukan bahwa kecepatan yang dianjurkan untuk mengendarai Kapal Gili CAT II sekitar 20-25 knot. Jika kapal dikendarai dengan kecepatan melebihi batas maksimum maka risiko kecelakan dan kerusakan pada mesin akan besar terjadi. Kapal Gili Cat II ini hanya dapat membawa 35 orang penumpang dan 4 awak kapal dengan massa maximum yang dapat dibawa sekitar 2 ton. Dapat dijelaskan hubungan massa dan kecepatan dalam hukum Newton 2 dimana massa mempengaruhi besar nilai kecepatan sehingga semakin besar massa maka kecepatan akan semakin besar.

Kata kunci: Hukum Newton 2, Kecepatan, Massa

Analysis of the Gili Cat II Ship Accident

Abstract

The purpose of this study is to find out what the recommended speed is for driving the Gili Cat II Ship and what happens when the Gili Cat II Ship is driven at a speed above the recommended limit and to find out the maximum mass that can be carried by the Gili Cat II Ship and find out relationship between mass and speed of the ship. The method used in this research is document qualitative method.The results of the case studies that have been conducted show that the recommended speed for driving the Gili CAT II Ship is around 20-25 knots. If the ship is driven at a speed exceeding the maximum limit, the risk of accidents and damage to the engine will be great. This Gili Cat II ship can only carry 35 passengers and 4 crew members with a maximum mass that can be carried around 2 tons. The relationship between mass and velocity can be explained in Newton's 2nd law where mass affects the value of velocity so that the greater the mass, the greater the speed.

Keywords: Newton's 2nd law, Velocity, Mass
Aplikasi Gaya Magnet Pada Fenomena Osilasi Teredam Dalam Sistem Gerak Harmonik Sederhana
Authors: Ghifari Muhammad Rajeev , Agung Pramono Rahmat , Nur Aziz Khafidh 
Published: August 2023

Telah dilaksanakan percobaan APLIKASI GAYA MAGNET PADA FENOMENA OSILASI TEREDAM DALAM SISTEM GERAK HARMONIK SEDERHANA bertempat di Laboratorium FMIPA, Lab. Fisika dasar, Universitas Negeri Yogyakarta yang bertujuan menginvestigasi pengaruh gaya magnet pada sistem gerak harmonik teredam. Metode yang penyusun gunakan ialah metode percobaan pendulum sederhana pada beban batu silinder dan beban bola besi yang kemudian direkam menggunakan smarphone dan ditrack dengan aplikasi tracker pada laptop. Pada analisis data, nilai faktor redaman osilasi pada beban batu silinder meningkat hingga bernilai , sementara nilai faktor redaman osilasi pada beban bola besi stabil di rentang nilai 0,08. Hal ini berarti osilasi pada beban batu silinder akan lebih cepat teredam menurut faktor waktu dibandingkan osilasi pada beban bola besi. Nilai kuadrat lebih dari nilai kuadrat yang berarti pada masing-masing sistem bekerja gerak osilasi redaman ringan (Light Damping). Analisis data juga menunjukkan bahwa gaya magnet berperan dalam mengurangi redaman pada sistem osilasi, mempertahankan gerak osilasi sehingga bandul memerlukan waktu lebih lama untuk mencapai posisi setimbang.
Two-Year Changes in Physical Activity and Concurrent Changes in Cognitive Function in a Cohort of Adults with Metabolic Syndrome
Authors: Rognoni Teresa , Fernández-Matarrubia Marta , Martinez-González Miguel Ángel , Salas-Salvadó Jordi , Corella Dolores , Castañer Olga , Martínez J. Alfredo , Alonso-Gómez Ángel M. , Gómez-Gracia Enrique , Vioque Jesús , Romaguera Dora , López-Miranda José , Estruch Ramón , Tinahones Francisco J. , Santos-Lozano José Manuel , Serra-Majem Lluis , Cano Ibañez Naomi , Tur Josep A. , Micó Pérez Rafael , Pintó Xavier , Delgado-Rodríguez Miguel , Ortiz Ramos María , Vidal Josep , Vázquez Clotilde , Daimiel Lidia , Ros Emilio , Goñi-Ruiz Nuria , Babio Nancy , Sorlí José V. , Schröder Helmut , García-Rios Antonio , Compañ-Gabucio Laura , Warnberg Julia , Zulet M. Ángeles , Chaplin Alice , Sacanella Emilio , Bouzalmate-Hajjaj Amira , Tojal-Sierra Lucas , Damas-Fuentes Miguel , Vázquez Zenaida , Gómez-Martínez Carlos , Saiz Carmen , Malcampo Mireia , Ortiz-Morales Ana M. , Martínez-Avilés Vanessa , García-Gavilan Jesús , Abete Itziar , Fitó Montserrat , Toledo Estefanía 
Published: August 2023

Background: It has been proposed that physical activity (PA) could prevent cognitive decline. Objective: To evaluate the association between changes in PA and changes in cognitive function in a cohort of adults with metabolic syndrome. Methods: Longitudinal observational study including 5,500 adults (mean age 65 years, SD = 5; women = 49.3% ) with metabolic syndrome. Participants underwent physical activity measurements and cognitive evaluation at baseline and at two-years of follow-up. PA was quantified using the Minnesota questionnaire-shortened version. Cognitive function was evaluated using a battery of tests: Mini-Mental Test Examination, Clock Drawing Test, Trail Making Test A and B, Verbal Fluency Test, and Digit Span. The primary outcome was two-year change in cognition, measured through the Global Composite Score (GCS) of all neuropsychological tests. Multivariable-adjusted linear regression models were fitted with baseline PA and their changes as the main exposures and changes in cognitive function as the outcome. Results: No significant association was found between PA levels (or their changes) in the GCS of cognitive function. A greater increase in PA levels was associated with a more favorable two-year change in the Trail Making Test A (Q4 versus Q1: b = – 2.24s, 95% CI –4.36 to –0.12s; p-trend = 0.020). No significant association was found for other neuropsychological test. Conclusion: Our results do not support an association between increases in PA and the evolution of the global cognitive function at two-year in an intervention trial which included PA promotion in one of its two randomized arms, but they suggested a possible beneficial effect of PA on attentional function in older adults.
Gut Microbiota and Cognitive Function Among Women Living with HIV
Authors: Hua Simin , Peters Brandilyn A. , Lee Susie , Fitzgerald Kathryn , Wang Zheng , Sollecito Christopher C. , Grassi Evan , Wiek Fanua , St Peter Lauren , D’Souza Gypsyamber , Weber Kathleen M. , Kaplan Robert C. , Gustafson Deborah , Sharma Anjali , Burk Robert D. , Rubin Leah H. , Qi Qibin 
Published: August 2023

Background: Altered gut microbiota has been associated with cognitive dysfunction and Alzheimer’s disease, but little is known among people living with HIV. Objective: To examine associations between gut microbiota and cognitive impairment among women with or without HIV. Methods: This is a cross-sectional study of 446 women (302 HIV+) who had completed a neuropsychological test battery and stool sample collected within 1 year. Gut microbiota composition was quantified using 16SV4 rRNA gene sequencing and microbial functional pathways were predicted using PICRUSt. Cognitive domains included attention, executive function, learning, memory, fluency, processing speed, and motor function. Cognitive impairment was defined as two or more domains with T scores < 1 SD below mean. ANCOM-II was used to identify taxa and functional pathways associated with cognitive impairment, and the associations were further examined by multivariable logistic regression. Results: In overall sample, adjusting for multiple covariates including HIV status, we found that higher abundance of Methanobrevibacter, Odoribacter, Pyramidobacter, Eubacterium, Ruminococcus, and Gemmiger, and lower abundance of Veillonella were associated with cognitive impairment. The associations between these taxa and cognitive impairment were more profound in HIV+ women compared to HIV- women. Most associations with bacterial taxa were observed for learning and memory. We found accompanying microbial functional differences associated with cognitive impairment, including twelve enriched pathways and three depleted pathways. Conclusions: In women with or without HIV infection, this study identified multiple altered gut bacterial taxa and functional pathways associated with cognitive impairment, supporting the potential role of gut microbiota in cognitive dysfunction and Alzheimer’s disease.
Preclinical Brain Network Abnormalities in Patients with Subjective Cognitive Decline
Authors: Serra Laura , Bonarota Sabrina , Di Domenico Carlotta , Caruso Giulia , Giulietti Giovanni , Caltagirone Carlo , Cercignani Mara , Bozzali Marco 
Published: August 2023

Background: Alzheimer’s disease (AD) is the most common form of dementia worldwide. Currently there are no disease modifying treatments available. Detecting subjects with increased risk to develop dementia is essential for future clinical trials. Subjective cognitive decline (SCD) is a condition defining individuals who perceive a decrease in their own cognitive functioning in the absence of any detectable deficit on neuropsychological testing. SCD individuals show AD-related biomarkers abnormalities in cerebrospinal fluid. Objective: The aim of the present study was to assess brain functional connectivity (FC) changes in SCD individuals. Methods: 23 SCD and 33 healthy subjects (HS) underwent an extensive neuropsychological assessment and 3T-MRI scanning including a T1-w volume and resting-state fMRI (RS-fMRI) to assess brain atrophy and brain FC. Results: No between-group differences in grey matter volumes were detected. SCD subjects compared to HS showed both increased and decreased FC in the executive and parietal networks. Associations between cognitive measures, mainly assessing working memory, and FC within brain networks were found both in SCD and HS separately. Conclusions: SCD individuals showed FC abnormalities in networks involving fronto-parietal areas that may account for their lower visuo-spatial working memory performances. Dysfunctions in executive-frontal networks may be responsible for the cognitive decline subjectively experienced by SCD individuals despite the normal scores observed by formal neuropsychological assessment. The present study contributes to consider SCD individuals in an early AD stage with an increased risk of developing the disease in the long term.
Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer’s Disease-Related Biomarkers
Authors: Schork Nicholas J. , Elman Jeremy A. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: August 2023

Background: APOE is the largest genetic risk factor for Alzheimer’s disease (AD), but there is a substantial polygenic component. Polygenic risk scores (PRS) can summarize small effects across the genome but may obscure differential risk across molecular processes and pathways that contribute to heterogeneity of disease presentation. Objective: We examined polygenic risk impacting specific AD-associated pathways and its relationship with clinical status and biomarkers of amyloid, tau, and neurodegeneration (A/T/N). Methods: We analyzed data from 1,411 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). We applied pathway analysis and clustering to identify AD-associated “pathway clusters” and construct pathway-specific PRSs (excluding the APOE region). We tested associations with diagnostic status, abnormal levels of amyloid and ptau, and hippocampal volume. Results: Thirteen pathway clusters were identified, and eight pathway-specific PRSs were significantly associated with AD diagnosis. Amyloid-positivity was associated with endocytosis and fibril formation, response misfolded protein, and regulation protein tyrosine PRSs. Ptau positivity and hippocampal volume were both related to protein localization and mitophagy PRS, and ptau-positivity was also associated with an immune signaling PRS. A global AD PRS showed stronger associations with diagnosis and all biomarkers compared to pathway PRSs. Conclusions: Pathway PRS may contribute to understanding separable disease processes, but do not add significant power for predictive purposes. These findings demonstrate that AD-phenotypes may be preferentially associated with risk in specific pathways, and defining genetic risk along multiple dimensions may clarify etiological heterogeneity in AD. This approach to delineate pathway-specific PRS can be used to study other complex diseases.
SAFETY OF REGIONAL ANESTHESIA IN UKRAINE SURVEY: ARE HOSPITALS READY FOR THE LOCAL ANESTHETIC SYSTEMIC TOXICITY (LAST)?
Authors: Semenko Nataliia , Frank Michael , Kuchyn Iurii , Bielka Kateryna , Spitsyn Vitalii , Parii Vasyl , Lykhodii Viktor 
Published: August 2023

Background. A survey was conducted among anesthesiologists in 38 Ukrainian hospitals to evaluate the current incidence and treatment quality of the local anesthetic systemic toxicity (LAST). With the growing preference for regional anesthetic techniques, implementation of measures for timely detection and treatment of LAST is becoming a priority for many surgical hospitals. This study aims to provide primary country-wide epidemiological data to guide further safety improvement in Ukraine.
It should be noted, that the survey was performed before the beginning of the full-scale Russian invasion of Ukraine. The resulting surge in the incidence of limb injury has resulted in an unprecedented scale of application of regional anesthesia, including out-of-hospital cases with very limited monitoring, which will no doubt generate great amount of new data on the subject. We hope that our current analysis may be used as a reference point for the future research on this subject.
Material and methods. A link to the survey was distributed via e-mail to the members of the Association of Anesthesiologists of Ukraine. Data submission was anonymous. Statistical analysis was performed using Microsoft Excel. Descriptive statistics are provided.
Results. Responses were submitted by 186 anesthesiologists from 38 Ukrainian cities. Among them, 65.9% practice in public hospitals, 25.4% - in private hospitals, 8.7% - in university hospitals. Majority of respondents (60.3%) reported performing over 100 regional anesthetic procedures per year. Peripheral nerve blocks were routinely performed in the hospitals of 76.9% of respondents. 42.4% are using peripheral nerve blocks or more times per week, 24.4% perform this amount monthly, 21.7% - yearly, with 11.5% not utilizing peripheral nerve blocks at all.
Ultrasound guidance was commonly used by 64.1% of anesthesiologists, 60.3% reported relying on landmark techniques often and 38.5% are routinely using a neuromuscular electrical stimulator.
LAST cases were previously encountered by 37.2% of respondents. However, only 37% have reported having a LAST protocol in their hospital and 42.3% did not have a lipid emulsion available. Regarding patient education, in 62.8% of cases the patients were specifically warned about the possible complications of regional anesthesia prior to procedures, where it was performed. When the local anesthetic related adverse events did occur, they were recorded in the patient’s card in 27.2% of cases; the chief of anesthesiology department was informed in 36.9%, while in 35.9% the event was not reported in any way.
Conclusions. The practice of regional anesthesia is becoming more widespread in Ukraine, but the minimal measures required to provide patient safety during such procedures are still not being employed in many hospitals.
MATHEMATICAL MODEL FOR PREDICTING THE SEVERITY OF THE COURSE OF ACUTE PANCREATITIS
Authors: Kolosovych I.V. , Bystrytska M.A. , Hanol I.V. 
Published: August 2023

Background. A feature of acute pancreatitis is the high risk of developing complications (occurring in 50% of patients), the mortality rate of which reaches 15%, and with a severe course varies within 40-70%. It has been proven that timely determination of the severity of the disease, selection of appropriate treatment tactics, early diagnosis of complications and their prevention significantly improve treatment results.
Aim: to develop a modern mathematical model for predicting the severity of the course of acute pancreatitis, taking into account indicators of calcium-phosphorus metabolism, hemocoagulation factors and serological examination data for Helicobacter pylori.
Materials and methods. The study was based on the results of an examination of 280 patients with acute pancreatitis, who were divided into two groups: the main group (n=187) – patients with a severe course and a comparison group (n=93) – patients with a mild and moderate course of the disease. To develop a mathematical model, the following indicators were analyzed and compared: duration of the disease before hospitalization, body mass index, number of leukocytes, C-reactive protein, blood glucose, procalcitonin, interleukin-6, immunoglobulin M to Helicobacter pylori, thrombin-antithrombin III complex, activity of tissue plasminogen activator, serum calcium, albumin corrected calcium, vitamin D.
Results. Based on the obtained results, we developed a mathematical model for predicting the severity of the course of acute pancreatitis and revealed a correlation between the calculated scores (according to the mathematical model) and the APACHE II scale (severe course of 8 points and more). The step-by-step creation of a model by the method of multiple regression analysis with a gradual decrease in the number of indicators from 12 to 8 and to 6 allowed us to propose a mathematical model that has high accuracy for predicting the severe course of acute pancreatitis (R=0.82; R2=0.66; p< 0.0001). The obtained data demonstrate the dependence of the "severe course" factor on the content of vitamin D, immunoglobulin M to Helicobacter pylori and the activity of tissue plasminogen activator and substantiate the need for their early determination in patients with acute pancreatitis. Therefore, the developed mathematical model is highly informative and can be used in medical practice for early prediction of the severe course of acute pancreatitis.
Conclusions. The dependence of the «severe course» factor in patients with acute pancreatitis on the content of vitamin D, immunoglobulin M to Helicobacter pylori and the activity of tissue plasminogen activator has been proven, and the need for their determination in the early period of the disease is substantiated. Using the method of multiple regression analysis, a mathematical model was developed that has high accuracy for predicting the severe course of acute pancreatitis (R=0.82; R2=0.66; p<0.0001).
METHODOLOGY FOR ASSESSMENT OF THE QUALITY OF LIFE OF CHILDREN WITH CORONA VIRUS INFECTION AND THE POST-VIDAL SYNDROME
Authors: Marushko Yu.V. , Shipelik T.V. , Hyschak T.V. , Kramarev S.O. , Kryuchko T.O. , Pisarev A.O. , Kryvopustov S.P. 
Published: August 2023

Background. The urgency of the problem is due to the rapid spread of the coronavirus infection in the world, as well as the frequent occurrence of a wide range of post-coronavirus complications in children, which significantly affect the quality of life. These changes also remain in the post-Covid period. Assessment of the quality of life in children with post-covid syndrome in Ukraine is at the stage of formation, therefore, methodologically, the creation and validation of children's questionnaires with subsequent assessment of the quality of life remains an urgent problem.
Aim: to summarize data from the literature regarding the study of health-related quality of life in children with SARS-CoV-2 infection and post-covid syndrome.
Materials and methods. An assessment of literature data on the frequency and course of coronavirus infection, its manifestations, damage to the respiratory system and other organs and systems in children, and asthenic manifestations was carried out.
Results. Based on the analysis of the scientific literature, the possibilities of using the quality of life assessment method in pediatric practice, in particular in children with COVID-19 and the consequences of the infection, were considered. One of the most frequently used questionnaires for assessing the quality of life in children is the PedsQL 4.0 questionnaire, which, due to good psychometric qualities, the availability of parallel forms for children and parents, a wide age range, simplicity and ease of filling out, can be recommended for determining the health-related quality of life in children. It is shown how the study of the quality of life related to health allows to study the impact of the disease and treatment on the components of the child's health.
Conclusions. Research on quality of life allows monitoring the condition of a child with post-covid syndrome during treatment and rehabilitation, as well as evaluating the effectiveness of these measures.