bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making sense of (un)sustainable food: creation of sharable narratives in citizen-participating farming
Authors: Watabe Atsushi 
Published: June 2023

AbstractThere has been broad recognition that current food systems need to go through a process of transformation and transition. In the similar way that other areas have transitioned to be more sustainable, the transition process for food systems has some issues related to justice in terms of achieving more sustainable and inclusive food production, distribution and consumption. Acknowledging the importance of these issues, this article aims to understand how knowledge about desired changes is produced and shared among people engaged in activities to transform food production and consumption. To this end, it analyses the short narratives of urban citizens in Japan engaged in participatory farming, adopting the concepts focusing on the contrasts embedded in the short stories, learning from risk studies. The farmer, volunteer staff members and urban citizens collaborate to grow rice using traditional techniques. Their narratives reveal some contrasts in how they used to engage with food, farms and the local environment, and their engagement now. Furthermore, it was observed that these citizens reconfirm the importance of knowledge learned through actual work on the farm and the different roles played by the farmer, volunteers and local participants in creating and passing on knowledge. In such ways, people’s interaction leads to the creation of shared meanings of “appropriateness” in terms of existing and emerging food-related practices. This matter of meaning-making for “appropriateness” is often overlooked in the discussion of the justice in food systems’ transitions.
Prostitution und Kriminologie
Authors: Steffan Christian , Weinand Marisa , Brettel Hauke 
Published: June 2023

ZusammenfassungIm Verhältnis von Kriminologie und Prostitution besteht schon mit Blick auf die Gefahr von Stigmatisierungen Klärungsbedarf. Zentrale Bedeutung hat dabei die Frage, ob das Anbieten oder die Inanspruchnahme von sexuellen Handlungen gegen Entgelt sowie damit im Zusammenhang stehende Verhaltensweisen als „Verbrechen“ anzusehen sind. Aber auch die aktuelle Handhabung der Prostitution durch die Rechtsordnung oder der Umgang mit Reformforderungen stehen mit Tatsachen im Zusammenhang, die an eine kriminologische Zuständigkeit denken lassen. Insbesondere widmet sich die Kriminologie – wie auch andere (forensische) Wissenschaften – der Faktenbasis einer Freiverantwortlichkeit, auf die es nicht zuletzt im Zusammenhang mit dem Anbieten von sexuellen Handlungen gegen Entgelt ankommt.
Implementing profession orientation as a design principle for overcoming Klein’s second discontinuity – preservice teacher’s perspectives on interface activities in the context of a geometry course
Authors: Hoffmann Max , Biehler Rolf 
Published: June 2023

AbstractIntending to counteract Klein’s second discontinuity in teacher education, we explored and applied the innovation of “interface ePortfolio” in the context of a geometry course for preservice teachers (PSTs). The tool offers the possibility of implementing the design principle of profession orientation. In the article, we theoretically clarify what we understand by this principle and locate our innovative concept against this theoretical background. We empirically investigate the extent to which counteraction against the second discontinuity is successful by analyzing reflection texts created in the interface ePortfolio, focusing on PSTs’ perspectives. Our qualitative content analysis shows that most of them perceive the innovation as helpful in the intended sense and indicates that the course concept, in general, and the interface ePortfolio, in particular, have helped establish relevant links between the course content and their later work as teachers.
Modelling approaches to particle deposition and clearance in the human respiratory tract
Authors: Lazaridis Mihalis 
Published: June 2023

AbstractDosimetry models for the estimation of particle deposition in the human respiratory tract (RT) in conjunction with clearance transport models are vital components to relate human exposure with internal dose in a quantitative manner. The current work highlights knowledge and modelling approaches on particle deposition and translocation in the human body in an effort to determine health risks in respect to different particle physicochemical properties and human physiology parameters. These include breathing conditions, variability of the geometry of the RT, chemical composition and size of deposits. Different dosimetry modelling approaches have been studied including empirical formulations, one-dimensional flow modelling and computational fluid dynamic methods (CFD). The importance of a realistic modelling of hygroscopicity has been also investigated. A better understanding of the relationship between health effects and inhaled particle dose may be elaborated using dosimetry and clearance modelling tools. A future required approach is to combine dosimetry models with physiologically based pharmacokinetic models (PBPK) to simulate the transport and cumulative dose of particle-bound chemical species in different organs and tissues of the human body.
Pilot study in Hamburg on the prevalence of SARS-CoV-2 infections and pandemic survey in the German funeral industry
Authors: Schädler Julia , Lütgehetmann Marc , Schröder Ann Sophie , Edler Carolin , Püschel Klaus , Ondruschka Benjamin , Fitzek Antonia 
Published: June 2023

AbstractFuneral home and crematorium workers are an important occupational group in the corona crisis. The occupational setting led to concerns about an increased risk of infection with SARS-CoV-2. The seroprevalence in this occupational group is unclear. A questionnaire-based retrospective survey of funeral home and crematorium staff was conducted in December 2020. A second survey of funeral and crematorium staff was conducted 6 months later, in June 2021, to determine changes in pandemic management. Seroprevalence or vaccination status for SARS-CoV-2 was determined at these two time points. In December 2020, a seroprevalence of 2.3% (n = 1/44) was detected in funeral home and crematorium workers. In June 2021, one additional participant tested positive for the SARS-CoV-2 nucleocapsid. Of the participants, 48.5% (n = 16) were vaccinated at this time. The risk of SARS-CoV-2 infection for funeral home and crematorium workers is more similar to that of the general population in Hamburg, Germany. We found no evidence of an increased risk of infection at these two time points in our cohort. Further education on communicable diseases or appropriate protective measures in this occupational group for other infectious diseases would be useful in the future.
Clathrin light chain A facilitates small extracellular vesicle uptake to promote hepatocellular carcinoma progression
Authors: Xu Yi , Yao Yue , Yu Liang , Fung Hiu Ling , Tang Alexander Hin Ning , Ng Irene Oi-Lin , Wong Melody Y. M. , Che Chi-Ming , Yun Jing Ping , Cui Yunfu , Yam Judy Wai Ping 
Published: June 2023

Abstract
Background
Endocytosis is a fundamental process for internalizing small extracellular vesicles (sEVs). The present study aimed to elucidate the role of clathrin light chain A (CLTA) in sEV uptake in hepatocellular carcinoma (HCC).

Materials and methods
CLTA expression was analyzed by bioinformatics, quantitative PCR and immunohistochemistry. The clinical relevance of CLTA was analyzed by Fisher’s exact test, Kaplan–Meier analysis, and multivariate cox regression model. The functions of CLTA in sEV uptake and cancerous properties were examined by PKH67-sEV uptake, MTT, colony formation, and transwell assays. Mass spectrometry was used to identify the downstream effectors of CLTA. CLTA inhibitor, Pitstop 2, was tested in a mouse model of patient-derived xenografts (PDXs).

Results
CLTA expression was higher in tumor tissues than in non-tumorous liver tissues and progressively increased from the early to late tumor stage. CLTA overexpression was associated with larger tumor size and poor prognosis in HCC. Cellular CLTA contributed to the sEV uptake, resulting in enhanced cancerous properties. Mechanistically, CLTA increases capping actin protein gelsolin-like (CAPG) expression to facilitate sEV uptake, thereby promoting the proliferation, motility, and invasiveness of HCC cells. What’s more, the CLTA inhibitor Pitstop 2 alone or in combination with sorafenib attenuated tumor growth in mice implanted with PDXs.

Conclusions
The study reveals the role of CLTA in sEV uptake to promote HCC progression. Inhibition of CLTA and its mediated pathway illuminate a new therapeutic strategy for HCC patients.
Empirical evidence of the parent company's influence on spin-off: from creation to performance
Authors: Oliveira Isabel , Figueiredo Jorge , Cardoso António , Cunha Maria Nascimento 
Published: June 2023

AbstractCompanies to adapt to today's society, characterized by continuous changes, adopt strategies to search for new opportunities, sometimes emerging business models, different from the parent company's business area. If they do not want to diversify their core business, they choose to create a new company that will be independent from the parent company, the spin-off. The aim of this study is to analyze and analyze the parent company's influence on spin-off performance, in terms of motivating factors for creation, transferred resources, relationship type and spin-off performance in the post-spin-off period. To achieve this objective, 31 surveys were analyzed, answered by workers who occupy management positions in spin-off companies in the USA and Canada. The statistical analysis of the data suggests that the concentration of the business area and the maximization of shareholder value are the main reasons for the creation of the spin-off. The most mentioned spin-off challenges are aggressive competition and efficient allocation of efficient resources. One of the characteristics of the spin-off is that it is an independent company, a fact that is not verified in the sample under analysis. However, the spin-off's performance does not change when it becomes independent.
MTHFR act as a potential cancer biomarker in immune checkpoints blockades, heterogeneity, tumor microenvironment and immune infiltration
Authors: Peng Jianheng , Wu Zhongjun 
Published: June 2023

AbstractPurposeTo evaluate the role and landscape of 5-10-Methylenetetrahydrofolate reductase (MTHFR) to immune infiltration, tumor microenvironment, heterogeneity, immune checkpoints blockades, prognostic significance across cancer types.MethodsData sets of genomic, transcriptomic and clinic features of MTHFR across > 60,000 patients and up to 44 cancer types were comprehensively analyzed using R software.ResultsExpression of MTHFR gene is significantly lower in 17 tumors and correlated with overall survival (OS), disease-specific survival (DSS), progression-free interval (PFI) in specific tumors. Gene alterations of MTHFR are observed significant differences across tumor types. Expression of MTHFR is negatively correlated with the stemness index (mDNAsi, mRNAsi, DMPsi, ENHsi, EREG-mDNAsi and EREG-mRNAsi) in the most cancers. MTHFR showed significantly correlated with 67 types of immune cell infiltration scores in 44 cancer types by XCELL algorithm. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis are conducted to show the core tumor mechanism and biological process. Correlations between MTHFR and biomarkers of heterogeneity (MSI, TMB, MATH, HRD, LOH, Neoantigen, ploidy and purity) are also significant in specific tumors. MTHFR is significantly positively correlated with biomarkers of immune related genes (CD19, CD274, CD80, CD86) and mismatched repair genes (MLH1, PMS2, MSH2, MSH6, EPCAM, MLH3, PMS1, EXO1) in most cancer types. Receiver Operating Characteristics (ROC) analyses show MTHFR could act as a potential biomarker in anti-PD-1 (nivolumab to melanoma) and anti-CTLA4 (ipilimumab to melanoma) group of ontreatment, in anti-PD-1 (pembrolizumab to melanoma) group of pretreatment. Two immunohistochemistry antibodies HPA076180 and HPA077255 are verified in 20 types of tumor and could be used to detect the expression of MTHFR efficiently in clinic.ConclusionsMTHFR could predict the response of immune checkpoints blockades, heterogeneity, tumor microenvironment and immune infiltration.
LncRNA MIR4435-2HG drives cancer progression by modulating cell cycle regulators and mTOR signaling in stroma-enriched subtypes of urothelial carcinoma of the bladder
Authors: Pei Lu , Yan Dong , He Qingqing , Kong Jianqiu , Yang Meihua , Ruan Honglian , Lin Qiongqiong , Huang Lifang , Huang Jian , Lin Tianxin , Qin Haide 
Published: June 2023

Abstract

Background
The risk for recurrence and metastasis after treatment for urothelial carcinoma of the bladder (UCB) is high. Therefore, identifying efficient prognostic markers and novel therapeutic targets is urgently needed. Several long noncoding RNAs (lncRNAs) have been reported to be correlated with UCB progression. In this study, we found that the subtype-specific lncRNA MIR4435-2 host gene (MIR4435-2HG) plays a novel oncogenic role in UCB.

Methods
RNA-Seq data of TCGA/BLCA were analyzed. The expression of MIR4435-2HG was measured by qRT-PCR in 16 pairs of bladder cancer tissues and adjacent normal tissues. The clinical relecance of MIR4435-2HG was validated via in situ hybridization performed on an in-house cohort of 116 UCB patient samples. RNA pull-down followed by mass spectrometry was performed to identify MIR4435-2HG-binding proteins. To identify signaling pathways involved in MIR4435-2HG activity, comprehensive in vitro and in vivo studies and RNA-Seq assays were performed using UCB cells in which MIR4435-2HG expression was knocked down or exogenously overexpressed. In addition, we performed RNA immunoprecipitation and Western blot analyses to validate the identified MIR4435-2HG-binding proteins and to determine the molecular mechanisms by which MIR4435-2HG promotes UCB progression.

Results
We found that MIR4435-2HG was significantly upregulated in the stromal-enriched subtype of UCB. Increased MIR4435-2HG expression was positively correlated with a high histological grade, advanced T stages, larger tumors, lymph node metastasis and a poor prognosis. In vitro experiments revealed that MIR4435-2HG expression silencing suppressed cell proliferation and induced apoptosis. Inhibition of MIR4434-2HG delayed xenograft tumor growth, while MIR4435-2HG overexpression reversed the MIR4435-2HG silencing-induced inhibition of UCB tumor phenotype acquisition. Mechanistically, we found that MIR4435-2HG positively regulated the expression of a variety of cell cycle regulators, including BRCA2 and CCND1. Knocking down MIR4435-2HG increased the sensitivity of tumor cells to the VEGFR inhibitor cediranib. Furthermore, we found that MIR4435-2HG regulated mTOR signaling and epithelial-mesenchymal transition (EMT) signaling pathways by modulating the phosphorylation of mTOR, 70S6K and 4EBP1. Finally, we confirmed that MIR4435-2HG enhances tumor metastasis through regulation of the EMT pathway.

Conclusions
Our data indicate that upregulated MIR4435-2HG expression levels are significantly correlated with a poor prognosis of UCB patients. MIR4435-2HG promotes bladder cancer progression, mediates cell cycle (de)regulation and modulates mTOR signaling. MIR4435-2HG is an oncogenic lncRNA in UCB that may serve as a diagnostic and therapeutic target.
Ukraine–Russia Conflict and Stock Markets Reactions in Europe
Authors: Das Bijoy Chandra , Hasan Fakhrul , Sutradhar Soma Rani , Shafique Sujana 
Published: June 2023

AbstractThis paper analyses the impact of Ukraine–Russia conflict on stock markets in Europe. We consider the stock markets of nine EU countries and Russia. The analysis consists of day-firm which includes the time between 24 November 2021 and 23 May 2022. We consider ordinary least squared (OLS) and fixed effects as baseline models. Additionally, we consider the impact of this conflict on stock return for several months, the elasticity test, the instrumental variable—two-stage least squared (2SLS) approach for the robustness test and endogeneity concerns. We find evidence of the negative impact of the Ukraine–Russia conflict on stock return of that stock markets. In addition, our finding indicates that the impact of this war on the mining construction and manufacturing sectors is greater than on other sectors because Russia and Ukraine are the key suppliers or exporters of mining and manufacturing sector. Our finding also indicates that Ukraine–Russia conflict largely affects stock return of Russian stocks because Russia is directly involved in the conflict.
Chronic kidney disease, female infertility, and medically assisted reproduction: a best practice position statement by the Kidney and Pregnancy Group of the Italian Society of Nephrology
Authors: Attini Rossella , Cabiddu Gianfranca , Ciabatti Francesca , Montersino Benedetta , Carosso Andrea Roberto , Gernone Giuseppe , Gammaro Linda , Moroni Gabriella , Torreggiani Massimo , Masturzo Bianca , Santoro Domenico , Revelli Alberto , Piccoli Giorgina Barbara ,   On behalf of the Italian Society of Nephrology’s Project Group on Kidney and Pregnancy
Published: June 2023

AbstractFertility is known to be impaired more frequently in patients with chronic kidney disease than in the general population. A significant proportion of chronic kidney disease patients may therefore need Medically Assisted Reproduction. The paucity of information about medically assisted reproduction for chronic kidney disease patients complicates counselling for both nephrologists and gynaecologists, specifically for patients with advanced chronic kidney disease and those on dialysis or with a transplanted kidney. It is in this context that the Project Group on Kidney and Pregnancy of the Italian Society of Nephrology has drawn up these best practice guidelines, merging a literature review, nephrology expertise and the experience of obstetricians and gynaecologists involved in medically assisted reproduction. Although all medically assisted reproduction techniques can be used for chronic kidney disease patients, caution is warranted. Inducing a twin pregnancy should be avoided; the risk of bleeding, thrombosis and infection should be considered, especially in some categories of patients. In most cases, controlled ovarian stimulation is needed to obtain an adequate number of oocytes for medically assisted reproduction. Women with chronic kidney disease are at high risk of kidney damage in case of severe ovarian hyperstimulation syndrome, and great caution should be exercised so that it is avoided. The higher risks associated with the hypertensive disorders of pregnancy, and the consequent risk of chronic kidney disease progression, should likewise be considered if egg donation is chosen. Oocyte cryopreservation should be considered for patients with autoimmune diseases who need cytotoxic treatment. In summary, medically assisted reproduction is an option for chronic kidney disease patients, but the study group strongly advises extensive personalised counselling with a multidisciplinary healthcare team and close monitoring during the chosen medically assisted reproduction procedure and throughout the subsequent pregnancy.
Graphical abstract
Real-time estimating method on rock strength via MWD of roofbolter and its application to in-situ grouting quality evaluation
Authors: Ma Bailong , Zhang Kai , Xiao Fangyuan , Yu Bosong , Xue Xinran , Jiang Tao , Zhang Houquan , Zhang Zhanrong 
Published: June 2023

AbstractGrouting reinforcement is an effective method for controlling fractured rock in the deeply buried roadways of coal mines. However, quantitatively evaluating the strength of grouted rock masses remains a challenge. The design of grouting reinforcement is primarily based on empirical knowledge. Consequently, this study proposes a real-time in-situ method for evaluating grouting quality using measure while drilling (MWD) based on a roofbolter. Initially, we validated the method through a numerical study using the discrete element method. Several 3D rock samples with varying crack densities were established and drilled numerically, demonstrating that the strength of fractured rock masses can be better estimated using the rock drillability index rather than drilling specific energy. Therefore, a model, known as the Pd–Rc model, was established to estimate rock strength based on the rock drillability index. Subsequently, an in-situ validation was conducted using a self-developed MWD testing system to assess the grouting quality in fractured rock masses. The results show that the strength of the rock mass increases by 38%, 56.0%, and 49.7%, respectively, after grouting, as observed in three boreholes. This method allows for quantitative estimation of grouting quality.
Fit for solving the grand challenges? From organization design choices to ecosystem solutions
Authors: Ambos Tina C. , Tatarinov Katherine 
Published: June 2023

AbstractThis Point of View article discusses the implications of different organization designs for solving the Grand Challenges. In line with this Special Issue, we view “organization designs as problem-solving systems”. However, we are skeptical that contemporary organization designs indeed “foster collective action that is needed to solve these grand challenges”. We outline different organization design choices for solving the grand challenges and provide a categorization of how selected types of organizations are fit to respond to these based on organizational goals (social–profit), organizational scale (local–global), and organizational decision making (agile–bureaucratic). In conclusion, we offer ideas on how to harness complementarities in different organization designs to develop collaborative ecosystem solutions.
A Comparison of Football Fan Activism in Ukraine and Germany
Authors: Brandt Christian , Krugliak Maryna , Warnecke Robert 
Published: June 2023

AbstractDuring the last decade, football fans in Germany and Ukraine have become increasingly active in the struggle for their interests. This article compares their respective activism based on reasons, tactics and spaces of activism over a span of eight years. The comparison shows that national politics are a dominant motive for Ukrainian fan activism, especially after the so-called Revolution of Dignity (Euromaidan) in 2014, including the Russian invasion. Politics is so important that activism is politically framed in this context even if non-political players like club management or the football association are addressed. In Germany, football’s governance is the major reason for fan activism, as fans strive to preserve or extend their influence on clubs’ and associations’ decisions. This difference emphasises the influence of national settings on fan activism. Concerning space and tactics, the samples show similarities, as in both countries ultras are the dominant type of fan group, an intersection of global ultra culture and activism tactics exists and activism mainly takes place in football stadiums. Therefore, fan activism can be understood as a globally connected movement that is nonetheless highly determined by the respective local context.