bluuebunny/crossref_metadata_2025_split huggingface dataset:
Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response
Authors: Zhang Le , Wirth Matthias , Patra Upayan , Stroh Jacob , Isaakidis Konstandina , Rieger Leonie , Kossatz Susanne , Milanovic Maja , Zang Chuanbing , Demel Uta , Keiten‐Schmitz Jan , Wagner Kristina , Steiger Katja , Rad Roland , Bassermann Florian , Müller Stefan , Keller Ulrich , Schick Markus 
Published: July 2023

AbstractThe DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Starting from an unbiased screening approach, we identified the SMC5‐SMC6 Complex Localization Factor 2 (SLF2) as a regulator of the DDR and biomarker for a B‐cell lymphoma (BCL) patient subgroup with an adverse prognosis. SLF2‐deficiency leads to loss of DDR factors including Claspin (CLSPN) and consequently impairs CHK1 activation. In line with this mechanism, genetic deletion of Slf2 drives lymphomagenesis in vivo. Tumor cells lacking SLF2 are characterized by a high level of DNA damage, which leads to alterations of the post‐translational SUMOylation pathway as a safeguard. The resulting co‐dependency confers synthetic lethality to a clinically applicable SUMOylation inhibitor (SUMOi), and inhibitors of the DDR pathway act highly synergistic with SUMOi. Together, our results identify SLF2 as a DDR regulator and reveal co‐targeting of the DDR and SUMOylation as a promising strategy for treating aggressive lymphoma.
Genetic effects on molecular network states explain complex traits
Authors: Weith Matthias , Großbach Jan , Clement‐Ziza Mathieu , Gillet Ludovic , Rodríguez‐López María , Marguerat Samuel , Workman Christopher T , Picotti Paola , Bähler Jürg , Aebersold Ruedi , Beyer Andreas 
Published: July 2023

AbstractThe complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but so far, no concept has been established to include the global network state. Here, we show when and how genetic perturbations lead to molecular changes that are confined to small parts of a network versus when they lead to modulation of network states. Integrating multi‐omics profiling of genetically heterogeneous budding and fission yeast strains with an array of cellular traits identified a central state transition of the yeast molecular network that is related to PKA and TOR (PT) signaling. Genetic variants affecting this PT state globally shifted the molecular network along a single‐dimensional axis, thereby modulating processes including energy and amino acid metabolism, transcription, translation, cell cycle control, and cellular stress response. We propose that genetic effects can propagate through large parts of molecular networks because of the functional requirement to centrally coordinate the activity of fundamental cellular processes.
Entrepreneurial Intentions: Between Entrepreneurial Knowledge, Entrepreneurial Skills and Perceived Control Behavior
Authors: Kurjono Kurjono 
Published: July 2023

This study aims to analyze the effect of entrepreneurial knowledge, entrepreneurial skills, and planned control behavior on entrepreneurial intentions. The grand theory used is Teri Planned Behavior from Ajzen (1991). The explanatory survey method was employed as the research method of the study. The research population comprised 506 students with a sample size of 218 respondents. The research sample was taken from a population of all Indonesian accounting education students consisting of students who had attended entrepreneurship courses from the Universitas Pendidikan Indonesian (UPI), Universitas Negeri Yogyakarta Negeri (UNY), Universitas Sebelas Maret (UNS), Universitas Negeri Surabaya (UNESA), Universitas Negeri Malang (UM), Universitas Negeri Makasar (UNM) and Universitas Negeri Medan (UNIMED). As the strategy to collect data, all questionnaires in this study have been tested for validity and reliability. Data were analyzed through descriptive analysis and path analysis. The results indicate that entrepreneurial knowledge did not affect perceived control behavior. Thus, variable trimming is conducted. Entrepreneurial skills have a positive effect on perceived control behavior. Similarly, entrepreneurial skills impact entrepreneurial intentions. Perceived behavior control has a positive effect on entrepreneurial intentions. Perceived behavior control is the most dominant variable in influencing entrepreneurial intentions. Future research is recommended to increase entrepreneurship from indicators of experience such as knowing client's problems and entrepreneurial skills, for example, indicators of recognizing opportunities, perceived behavior control through indicators of having opportunities for success, and entrepreneurial intentions through the business ability to start a business.
Total thyroidectomy: reduction in postoperative hypoparathyroidism
Authors: Reinke Rasmus , Londero Stefano Christian , Almquist Martin , Rejnmark Lars , Rolighed Lars 
Published: July 2023

Objective
Total thyroidectomy is associated with a high risk of postoperative hypoparathyroidism, mainly due to the unintended surgical damage to the parathyroid glands or their blood supply. It is possible that surgeons who also perform parathyroid surgery see lower rates of postoperative hypoparathyroidism. In a single institution, we investigated the effects of restricting total thyroidectomy operations for Graves’ disease to two surgeons who performed both thyroid and parathyroid surgeries. We aimed to evaluate the rates of postoperative hypoparathyroidism in a 10-year period with primary attention toward patients with Graves’ disease.

Design
Retrospective cohort study from a single institution.

Methods
We defined the rate of permanent hypoparathyroidism after total thyroidectomy as the need for active vitamin D 6 months postoperatively. Between 2012 and 2016, seven surgeons performed all thyroidectomies. From January 2017, only surgeons also performing parathyroid surgery carried out thyroidectomies for Graves’ disease.

Results
We performed total thyroidectomy in 543 patients. The rate of permanent hypoparathyroidism decreased from 28% in 2012–2014 to 6% in 2020–2021. For patients with Graves’ disease, the rate of permanent hypoparathyroidism decreased from 36% (13 out of 36) in 2015–2016 to 2% (1 out of 56) in 2020–2021. In cancer patients, the rate of permanent hypoparathyroidism decreased from 30% (14 out of 46) in 2012–2014 to 10% (10 out of 51) in 2020–2021.

Conclusion
Restricting thyroidectomy to surgeons who also performed parathyroid operations reduced postoperative hypoparathyroidism markedly. Accordingly, we recommend centralisation of the most difficult thyroid operations to centres and surgeons with extensive experience in parathyroid surgery.

Significance statement
Thyroid surgery is performed by many different surgeons with marked differences in outcome. Indeed, the risk of postoperative permanent hypoparathyroidism may be very high in low-volume centres. This serious condition affects the quality of life and increases long-term morbidity and the patients develop a life-long dependency of medical treatments. We encountered a high risk of hypoparathyroidism after the operation for Graves’ disease and restricted the number of surgeons to two for these operations. Further, these surgeons were experienced in both thyroid and parathyroid surgeries. We show a dramatic reduction in postoperative hypoparathyroidism after this change. Accordingly, we recommend centralisation of total thyroidectomy to surgeons with experience in both thyroid and parathyroid procedures.
Joachim Lelewel’s Collections Journey from Kórnik to Vilnius
Authors: Leonavičiūtė Inga 
Published: July 2023

Vilnius University Library possesses in its collections the personal library of distinguished historian, Joachim Lelewel (1786–1861), an alumnus and a professor of the Imperial University of Vilna. It consists of books, atlases, maps and other stocks gathered by Lelewel during his exile in Paris and Brussels. In his will, Lelewel bequeathed his library to Vilnius University, should that remembrance institution be restored. The library was temporarily stored at several locations, such as the Polish School at Batignolles (Paris), and Kórnik Library after 1874. In the fall of 1919 Vilnius University was reestablished by the Polish government under the name Stefan Batory University. The institution inherited former university’s meager library which had experienced heavy losses and deprivation during the decades of the Russian rule. Bringing to Vilnius extensive assets of printed and archival records gathered by the Polish emigrants in Western Europe through the 19th century was a great opportunity for the university library as it might significantly enrich its modest possessions. Lelewel’s personal library as well as Library and Archives of the Polish Museum at Rapperswil (Switzerland) were considered as first to be transferred. This article uses archival data to reconstruct almost a four-year long (February 1922 – end of 1925) journey of the Lelewel’s library from Kórnik to Vilnius.
The Crosstalk between Nephropathy and Coagulation Disorder: Pathogenesis, Treatment, and Dilemmas
Authors: Qiu Zhiwei , Pang Xiaocong , Xiang Qian , Cui Yimin 
Published: July 2023

ABSTRACT
The interaction between the kidney and the coagulation system greatly affects each other because of the abundant vessel distribution and blood perfusion in the kidney. Clinically, the risks of complicated thrombosis and bleeding have become important concerns in the treatment of nephropathies, especially nephrotic syndrome, CKD, ESKD, and patients with nephropathy undergoing RRTs. Adverse effects of anticoagulant or procoagulant therapies in patients with nephropathy, especially anticoagulation-related nephropathy, heparin-induced thrombocytopenia, and bleeding, seriously worsen the prognosis of patients, which have become challenges for clinicians. Over the decades, the interaction between the kidney and the coagulation system has been widely studied. However, the effects of the kidney on the coagulation system have not been systematically investigated. Although some coagulation-related proteins and signaling pathways have been shown to improve coagulation abnormalities while avoiding additional kidney damage in certain kidney diseases, their potential as anticoagulation targets in nephropathy requires further investigation. Here, we review the progression of research on the crosstalk between the coagulation system and kidney diseases and systematically analyze the significance and shortcomings of previous studies to provide new sight into future research. In addition, we highlight the status of clinical treatment for coagulation disorder and nephropathy caused by each other, indicating guidance for the formulation of therapeutic strategies or drug development.
The 2017 North Carolina STOP Act is Associated With an Accelerated Decrease in Opioid Dispensing: A Statewide Analysis, 2013–2019
Authors: Gillette Chris , Brooks Amber K. , Bodner Gayle B. , Perry Courtney J. 
Published: July 2023

Background This study aimed to: 1) quantify the dispensing and days’ supply of opioid prescriptions prior to and after the NC STOP Act went into effect among Medicare Part D beneficiaries; 2) evaluate how the STOP Act impacted physician assistant and nurse practitioner opioid prescribing; and 3) evaluate whether the NC STOP Act is associated with reductions in opioid prescriptions’ days’ supply among Medicare Part D beneficiaries. Methods This was a secondary analysis of Medicare Part D Public Use Files for 2013–2019. Only North Carolina providers and select Schedule II (CII) and III (CIII) drugs and tramadol (CV) were included in the analysis. Multivariable Poisson regression models were used to analyze the data. Results In 2013, there were population-adjusted 180,565.2/100,000 claims for the included CII and CIII opioids, which decreased to 79,329.12/100,000 claims in 2019. Each of the multivariable Poisson regression models indicates a reduction in per-provider populationadjusted claims and days’ supply after the NC STOP Act went into effect for both selected CII and CIII medications and for tramadol. The results also indicate that the number of prescriptions for CII, CIII, and tramadol decreased over time. Limitations Due to the nature of the observational study design, we cannot conclude that the 2017 legislation had an effect on populationadjusted claims for certain CII and CIII opioids. Conclusions Since 2013 there has been a decreasing trend in certain CII and CIII opioids dispensations in Medicare beneficiaries, and the trend accelerated after the STOP Act went into effect.
Viscoelastic effects under water-polymer flooding conditions of the fractured-porous reservoir
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Pogrebnyak Volodymyr G. , Shimanskii Volodymyr Y. ,   Ivano-Frankivsk National Technical University of Oil and Gas, Pogrebnyak Andriy V. ,   Ivano-Frankivsk National Technical University of Oil and Gas, Perkun Iryna V. ,   Ivano-Frankivsk National Technical University of Oil and Gas
Published: July 2023

The work is devoted to the numerical simulation of the flow of simple and viscoelastic (polymer solution) fluids through a fracture by using polymer solutions for enhanced oil recovery from a reservoir. Polymer solutions have viscoelastic properties. Therefore, when polymer solution flows through the slot, we use the well-known Maxwell’s fluid model with the Jaumann derivative to evaluate deformation characteristics of the flow (stream functions, distributions of the longitudinal velocity gradient and normal stress) resulting in the manifestation of abnormal (compared with the behaviour of the ordinary fluid) effects. The case of slow flow is considered. In this case, the inertial terms can be neglected, the velocities, stresses, and stream functions can be written as the decomposition by Weisenberg number, and we can assume that the Weissenberg number is less than one. The determined regularities of viscoelastic (polymer solution) liquid behaviour with longitudinal velocity gradient and the elastic deformations effects manifested in this case have a decisive meaning in understanding the mechanism of anomalously high oil recovery capacity of a reservoir by using water-polymer flooding of the fractured-porous reservoir. Understanding the nature of the effects of elastic deformations under the conditions of water-polymer flooding of the fractured-porous reservoir enables hydrodynamic calculations of the optimal flow of the polymer solution. One of the main issues that need to be solved when developing the technology for increasing oil recovery from formations using polymer solutions is to determine the optimal flow regime in the fractured-porous reservoir. The calculation results verify the ideas obtained from the experimental solution of this problem concerning the strain-stress state of polymer macromolecules (liquid elements) during polymer flow in the inlet area of the fracture in the oil reservoir and confirm the possibility of using numerical analysis of convergent polymer flow for calculating longitudinal velocity gradients in the inlet area of the fracture and can also serve as additional substantiation of the proposed earlier mechanism for increasing oil recovery from reservoirs by using polymer solutions.
Development of effective sealing units for oil and gas equipment in the oil and gas production system
Authors:   Azerbaijan State Oil and Industry University, Hasanov Ilman I. , Guliyev Agali A. ,   Azerbaijan State Oil and Industry University
Published: July 2023

The paper presents the results of many years of experience in studying the efficiency of sealing units in the conditions of their operation in the oil and gas production system, as well as the influence of technological parameters that ensure normal operation and protect them from failure due to leakage through the working surface of the seals in the friction zone. In addition, according to the results of practical studies, it has been established that, in order to improve the elastic properties, for example, of cup springs of a direct-flow valve, we calculated heat treatment of the operational values of spring compression for various material thicknesses. The work of the elastic elements of the packer was improved mainly by the design, and the optimal parameters for the development of the elastic element of the packer were determined. The study of the stress-strain state of the sealing element of packers during setting and improving its performance is of both practical and scientific interest. One of the factors that significantly affect operation of pumps is the fluid leakage in valve assemblies in order to identify the effect of the above parameters on tightness based on a preliminary theoretical analysis. Comparison of data during the study showed that the flow rate of work with low viscosities is greater than with high viscosities. The technological processes of hardening the parts of the shut-off assembly of X-mas tree valves, to increase their reliability, are considered. The dependence of the compression force of the spring and its deformation because of geometric parameters of the disk springs has been determined; it has been found that the residual deformation of the disk spring after collapse has a negative effect on tightness. Calculations show that the amount of leakage of the elastic elements in the sealing assembly should not exceed ≤0.309, since the seal at the value of elastic energy deformation provides a self-compacting mode. Thus, the degree of uneven pressing of the seat to the surface of the gate and its regulation to prevent leakage is practically determined.
Novel Fluoride Matrix for Dual‐Range Optical Sensors and Visualization
Authors: Alexandrov Alexander A. , Petrova Lada A. , Pominova Daria V. , Romanishkin Igor D. , Tsygankova Maria V. , Kuznetsov Sergey V. , Ivanov Vladimir K. , Fedorov Pavel P. 
Published: July 2023

Novel tetragonal matrix Ba0.5Gd0.5-xNaxF2.5-x, where x = 0.05, doped by Yb3+, Ho3+, Er3+, was synthesized by molten salt synthesis (MSS) from nitrate flux. XRD data show that tetragonal phase with a = 4.122(1) Å, c = 17.672(1) Å is stable in argon atmosphere up to 960 °C. Luminescence spectra recorded in 500-900 nm and 1050-1700 nm upon 974 nm pumping demonstrated the characteristic luminescence at 1550 nm (4I13/2 → 4I15/2) for Er3+ and 1150 nm (5I6 → 5I8) for Ho3+. The relative thermal sensitivity (Sr) at 296-316 K were 0.3 %*K-1 and 5.5%*К-1 in shortwave infrared (SWIR) and visible range, respectively. Synthesized luminophores can be used as dual-range optical temperature sensors, which simultaneously operating in visible and SWIR ranges.
Acetabular Sector Angles in Asymptomatic and Dysplastic Hips
Authors: Verhaegen Jeroen C.F. , DeVries Zach , Horton Isabel , Slullitel Pablo A. , Rakhra Kawan , Beaulé Paul E. , Grammatopoulos George 
Published: July 2023

Background:
Radiographic evaluation plays an important role in detecting and grading hip dysplasia. Acetabular sector angles (ASAs) measure the degree of femoral head coverage provided by the acetabulum on computed tomographic (CT) scans. In this study, we aimed to determine ASA values at different axial levels in a control cohort with asymptomatic, high-functioning hips without underlying hip pathology and a study group with symptomatic, dysplastic hips that underwent periacetabular osteotomy (PAO), thereby defining the ASA thresholds for hip dysplasia.

Methods:
This was a cross-sectional study evaluating a control group of 51 patients (102 hips) and a study group of 66 patients (72 hips). The control group was high-functioning and asymptomatic, with an Oxford Hip Score of >43, did not have osteoarthritis (Tönnis grade ≤1), underwent a pelvic CT scan, had a mean age (and standard deviation) of 52.1 ± 5.5 years, and was 52.9% female. The study group had symptomatic hip dysplasia treated with PAO, had a mean age of 29.5 ± 7.3 years, and 83.3% was female. Anterior ASA (AASA) and posterior ASA (PASA) were measured at 3 axial CT levels to determine equatorial, intermediate, and proximal ASA. The thresholds for dysplasia were determined using receiver operating characteristic (ROC) curve analysis, including the area under the curve (AUC).

Results:
Patients with dysplasia had significantly smaller ASAs compared with the control group; the differences were most pronounced for proximal AASAs and proximal and intermediate PASAs. The control group had a mean proximal PASA of 162° ± 17°, yielding a threshold for dysplasia of 137° (AUC, 0.908). The mean intermediate PASA for the control group was 117° ± 11°, yielding a threshold of 107° (AUC, 0.904). The threshold for anterior dysplasia was 133° for proximal AASA (AUC, 0.859) and 57° for equatorial AASA (AUC, 0.868). The threshold for posterior dysplasia was 102° for intermediate PASA (AUC, 0.933).

Conclusions:
Measurement of ASA is a reliable tool to identify focal acetabular deficiency with high accuracy, aiding diagnosis and management. A proximal PASA of <137° or an intermediate PASA of <107° should alert clinicians to the presence of dysplasia.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Comparative Evaluation of a Functions for the Soave-Redlich-Kwong Equation of State and the Peng-Robinson Equation of State to Predict Saturation Pressures for Gas(es)-Heavy Oil/Bitumen-Water Systems
Authors: Atonge Esther Anyi , Yang Daoyong 
Published: July 2023

Summary
To accurately predict saturation pressures for gas(es)-heavy oil/bitumen-water systems, several α functions have been selected and evaluated at a reduced temperature (Tr) of 0.70 and 0.60 for the Soave-Redlich-Kwong equation of state (EOS) and Peng-Robinson (PR) EOS, respectively. More specifically, 164 data points of measured saturation pressures of gas(es)-heavy oil/bitumen-water systems are collected from the public domain, while all α functions developed for heavy oil-associated mixtures and water have been reviewed and selected. At Tr = 0.70, the former, including three existing α functions, as well as two newly developed α functions at Tr = 0.70 together with three new α functions at Tr = 0.60, and the latter, including two alpha functions, are used to evaluate saturation pressures for various gas(es)-heavy oil/bitumen-water systems under various conditions. The absolute average relative deviation (AARD) between the measured saturation pressures and their predicted ones is found to decrease with either an increase in the pseudocomponent (PC) number or redefining the acentric factor (ω) at Tr = 0.60 other than the conventional one at Tr = 0.70. In addition to validating our coded program, the CMG WinProp module, together with its default binary interaction parameters (BIPs) is used to, respectively, quantify saturation pressures of the aforementioned systems with an overall AARD of 27.34 and 28.39% for the PR EOS and SRK EOS. The recommended α function newly developed at Tr = 0.60 by Chen and Yang (2017) predicts saturation pressures more accurately with an overall AARD of 3.88 and 1.64% by, respectively, treating the heavy oil as one PC and six PCs.