bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Physiological Response of Ornamental Summer Season Annuals to Salinity Stress
Authors: Arzoo  , Dubey R. K. , Dubey Manisha , Deepika Ravi , Pant Kritika 
Published: July 2023

Over the past several decades, the southwest zone of Punjab is encountering various problems such as waterlogging, high use of surface canal water for irrigation and swift rise in water demand lead to stagnation in saline zone due to salinity ingression. Due to salinization, most of crops failed to grow, therefore, identification of salt tolerant plants and to check the level of tolerance to salinity in order to prevent mortality plants in salt affected areas is highly required for environment sustainability. To understand these salinity issues, the present study was conducted at Punjab Agricultural University to screen four ornamental summer season annual species suitable for salt affected areas of Punjab. Selection of plant species was done on the basis of physiological changes in plant leaves. The one month old seedlings of four different annual species were grown in 8 inch earthen pots were exposed to five different concentrations of sodium chloride salinity stress (control, 30, 60, 90, and 120 mM). The factorial completely randomized block design was followed in the experiment with three replicates in each treatment. The physiological parameters viz., chlorophyll, carotenoid, relative leaf water content, electrolyte leakage and proline content were calculated to depict the salt tolerant ornamental summer season annual species. It has been concluded on the basis of physiological response, the maximum salt tolerance was observed in P. grandiflora followed by B. scoparia, T. erecta and Z. elegans.
Efficacy of Jatropha curcas Leaf Extract on Some Isolates Associated with Surgical Wounds
Authors: Ikoyi Tobias Agada , Ashien Uju Uchenna , Bobzom Banyonga Saidu , Wilson Ime Aniema-Abasi , Aniefiok Akpabio Ukemeobong , Obi-Anyaorah Chidimma Rosemary 
Published: July 2023

Aim: The aim of this study is to determine the antibacterial efficacy of Jatropha curcas leaf extract against some isolates associated with surgical wounds.
Study Design: This was a hospital-based study conducted in 2017 in the Department of medical microbiology unit of Bingham university teaching hospital and the national veterinary research institute (NVRI) both institutions are located in Jos Plateau State Nigeria.
Methodology: A total of twenty (20) isolates from clinical specimens of surgical wounds were used. The following bacteria were identified using biochemical analysis: Staphylococcus aureus (15), Pseudomonas aeruginosa (2), and Klebsiella pneumoniae (3). Using standard methods of ethanol and aqueous extraction techniques, the leaves of the Jatropha curcas were examined for phytochemical content. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the isolate were determined using the broth dilution method, while the antibacterial activity of the isolate was observed using the agar well diffusion techniques.
Results: The result of the phytochemical extraction shows the presence of the following Alkaloids (secondary metabolite) Saponins, Tannins, glycosides, Flavonoids, Oxalate, Terpenoids, Resins and steroids. The ethanol extract of Jatropha curcas exhibited antimicrobial activity against all the test bacteria with higher activity recorded with Staphylococcus aureus (15 mm) followed by Klebsiella pneumonia (12 mm) and Pseudomonas aeruginosa (10 mm). Aqueous extract of Jatropha curcas leaves did not exhibit significant antimicrobial activity against all the test isolates when compared to Ethanol Extraction However Aqueous extract of Jatropha curcas had a slight antimicrobial activity against only Staphylococcus aureus in the range of (5 mm to 7 mm). The MIC value for the ethanol extract of Jatropha curcas ranged from 100mg/ml to 200mg/ml while the MIC value for the aqueous extract was 200mg/ml.
Conclusion: The result of the present study shows that the ethanol and aqueous extracts of Jatropha Curcas leaves possess some antibacterial activities. The ethanol extract had higher antimicrobial activity than the aqueous extract on surgical wounds. It could therefore be inferred that these leaves contain bioactive constituents which can effectively inhibit the growth of some microorganisms. The plant could be used as an alternative therapy in the treatment of surgical wounds.
State Public Insurance Coverage Policies and Postpartum Care Among Immigrants
Authors: Steenland Maria W. , Fabi Rachel E. , Bellerose Meghan , Desir Arielle , White Maggie S. , Wherry Laura R. 
Published: July 2023

ImportanceProfessional medical organizations recommend that adults receive routine postpartum care. Yet, some states restrict public insurance coverage for undocumented immigrants and recently documented immigrants (those who received legal documentation status within the past 5 years).ObjectiveTo examine the association between public insurance coverage and postpartum care among low-income immigrants and the difference in receipt of postpartum care among immigrants relative to nonimmigrants.Design, Setting, and ParticipantsA pooled, cross-sectional analysis was conducted using data from the Pregnancy Risk Assessment Monitoring System for 19 states and New York City including low-income adults with a live birth between 2012 and 2019.ExposureGiving birth in a state that offered public insurance coverage for postpartum care to recently documented or undocumented immigrants.Main Outcomes and MeasuresSelf-reported receipt of postpartum care by the category of coverage offered (full coverage: states that offered publicly funded postpartum care regardless of immigration status; moderate coverage: states that offered publicly funded postpartum care to lawfully residing immigrants without a 5-year waiting period, but did not offer postpartum care to undocumented immigrants; no coverage: states that did not offer publicly funded postpartum care to lawfully present immigrants before 5 years of legal residence or to undocumented immigrants).ResultsThe study included 72 981 low-income adults (20 971 immigrants [29%] and 52 010 nonimmigrants [71%]). Of the 19 included states and New York City, 6 offered full coverage, 9 offered moderate coverage, and 4 offered no coverage; 1 state (Oregon) switched from offering moderate coverage to offering full coverage. Compared with the states that offered full coverage, receipt of postpartum care among immigrants was 7.0–percentage-points lower (95% CI, −10.6 to −3.4 percentage points) in the states that offered moderate coverage and 11.3–percentage-points lower (95% CI, −13.9 to −8.8 percentage points) in the states that offered no coverage. The differences in the receipt of postpartum care among immigrants relative to nonimmigrants were also associated with the coverage categories. Compared with the states that offered full coverage, there was a 3.3–percentage-point larger difference (95% CI, −5.3 to −1.4 percentage points) in the states that offered moderate coverage and a 7.7–percentage-point larger difference (95% CI, −10.3 to −5.0 percentage points) in the states that offered no coverage.Conclusions and RelevanceCompared with states without insurance restrictions, immigrants living in states with public insurance restrictions were less likely to receive postpartum care. Restricting public insurance coverage may be an important policy-driven barrier to receipt of recommended pregnancy care and improved maternal health among immigrants.
Cu(III) Trifluoromethyl Complexes with 1,3‐Diketonate Ligands and Their Versatile Reactivity in C−H Trifluoromethylation
Authors: Motornov Vladimir , Klepetářová Blanka , Beier Petr 
Published: July 2023

AbstractHigh‐valent Cu(III) trifluoromethyl complexes with 1,3‐diketonates as bidentate oxygen donor ligands LCu(III)(CF3)2 were prepared for the first time and fully characterized, including by X‐ray crystallography. These complexes are bench stable and soluble in most organic solvents. Promising reactivity of Cu(III) trifluoromethyl diketonates in radical and radical‐polar crossover trifluoromethylation reactions was demonstrated. Direct C−H trifluoromethylation of electron‐rich arenes and indoles using Cu(III) trifluoromethyl diketonates under blue light irradiation is described. Azolo‐ and oxy‐trifluoromethylation of terminal alkynes and S‐trifluoromethylation of aromatic thiol can be achieved using LCu(III)(CF3)2 in mild conditions.
Hypoiodite‐Catalyzed Oxidative α‐C−N Coupling of Ketones with Imides and Azoles
Authors: Tsukahara Mayuko , Uyanik Muhammet , Ishihara Kazuaki 
Published: July 2023

AbstractHerein, we report a direct method for the synthesis of α‐imidoketones and α‐azolylketones via hypoiodite‐catalyzed oxidative α‐C−N coupling of ketones with the corresponding imides and azoles, respectively. The use of inorganic base additives such as cesium carbonate in the presence of 18‐crown‐6 as a phase transfer catalyst was crucial to induce high reactivity. Control experiments revealed that the basic additives might not only facilitate high‐turnover hypoiodite catalysis, but also be involved in the activation of coupling partners.
Prodromal dementia with Lewy bodies in REM sleep behavior disorder: A multicenter study
Authors: Joza Stephen , Hu Michele T. , Jung Ki‐Young , Kunz Dieter , Arnaldi Dario , Lee Jee‐Young , Ferini‐Strambi Luigi , Antelmi Elena , Sixel‐Döring Friederike , De Cock Valérie Cochen , Montplaisir Jacques Y. , Welch Jessica , Kim Han‐Joon , Bes Frederik , Mattioli Pietro , Woo Kyung Ah , Marelli Sara , Plazzi Giuseppe , Mollenhauer Brit , Pelletier Amelie , Razzaque Jamil , Sunwoo Jun‐Sang , Girtler Nicola , Trenkwalder Claudia , Gagnon Jean‐François , Postuma Ronald B. ,   for the International REM Sleep Behavior Disorder Study Group
Published: July 2023

AbstractINTRODUCTIONIsolated/idiopathic rapid eye movement sleep behavior disorder (iRBD) is a powerful early predictor of dementia with Lewy bodies (DLB) and Parkinson's disease (PD). This provides an opportunity to directly observe the evolution of prodromal DLB and to identify which cognitive variables are the strongest predictors of evolving dementia.METHODSIRBD participants (n = 754) from 10 centers of the International RBD Study Group underwent annual neuropsychological assessment. Competing risk regression analysis determined optimal predictors of dementia. Linear mixed‐effect models determined the annual progression of neuropsychological testing.RESULTSReduced attention and executive function, particularly performance on the Trail Making Test Part B, were the strongest identifiers of early DLB. In phenoconverters, the onset of cognitive decline began up to 10 years prior to phenoconversion. Changes in verbal memory best differentiated between DLB and PD subtypes.DISCUSSIONIn iRBD, attention and executive dysfunction strongly predict dementia and begin declining several years prior to phenoconversion.Highlights
Cognitive decline in iRBD begins up to 10 years prior to phenoconversion.
Attention and executive dysfunction are the strongest predictors of dementia in iRBD.
Decline in episodic memory best distinguished dementia‐first from parkinsonism‐first phenoconversion.
Palladium‐Catalyzed Arylation of Endocyclic 1‐Azaallyl Anions: Concise Synthesis of Unprotected Enantioenriched cis‐2,3‐Diarylpiperidines
Authors: Zhang Biao , Ruan Junhao , Seidel Daniel , Chen Weijie 
Published: July 2023

AbstractUnprotected cis‐2,3‐diarylpiperidines are synthesized through an unprecedented palladium‐catalyzed cross‐coupling reaction between aryl halides and elusive endocyclic 1‐azaallyl anions. These intermediates are generated in situ by the deprotonation of 2‐aryl‐1‐piperideines, precursors that are readily prepared in two operations from simple piperidines. An asymmetric version of this reaction with (2R, 3R)‐iPr‐BI‐DIME as the ligand provides products in moderate to good yields and enantioselectivities. This study significantly expands the synthetic utility of endocyclic 1‐azaallyl anions.
Asymmetric Intramolecular Hydroalkylation of Internal Olefin with Cycloalkanone to Directly Access Polycyclic Systems
Authors: Wang Ai‐Fang , Tian Jin‐Miao , Zhao Xiao‐Jing , Li Zi‐Hao , Zhang Ye , Lu Ka , Wang Hong , Zhang Shu‐Yu , Tu Yong‐Qiang , Ding Tong‐Mei , Xie Yu‐Yang 
Published: July 2023

AbstractAn asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine (SPD‐NH2) and PdII complex, providing straightforward access to either bridged or fused bicyclic systems containing three stereogenic centers with excellent enantioselectivity (up to 99 % ee) and diastereoselectivity (up to >20 : 1 dr). Notably, the bicyclic products could be conveniently transformed into a diverse range of key structures frequently found in bioactive terpenes, such as Δ6‐protoilludene, cracroson D, and vulgarisins. The steric hindrance between the Ar group of the SPD‐NH2 catalyst and the branched chain of the substrate, hydrogen‐bonding interactions between the N−H of the enamine motif and the C=O of the directing group MQ, and the counterion of the PdII complex were identified as key factors for excellent stereoinduction in this dual catalytic process by density functional theory calculations.
A high thermal stable pre‐oxidized polyacrylonitrile nanofiber separator for lithium‐ion battery
Authors: Huang Haitao , Yu Bin , Wang Xiaokuan 
Published: July 2023

AbstractThe separator as a main part of lithium‐ion batteries (LIBs) acts as a primary factor that affects the safety property of the battery. The pre‐oxidized PAN (OPAN) separator as an alternative separator with high temperature resistance was developed through the electrospinning of PAN by thermal stabilization. The prepared OPAN separator showed an exceptional dimensional thermal stabilization, without obvious dimensional shrinkage after treated in the oven at 300°C for 30 min, which improves the safety of LIBs at high temperatures. The OPAN separator had a high porosity and excellent affinity to the electrolyte, along with 351.3% of electrolyte uptake. Furthermore, the ionic conductivity and the interfacial resistance of OPAN separator were 1.63 mS/cm and 881 Ω, better than 0.65 mS/cm and 1463 Ω of commercial Celgard 2400 separator. In addition, the LiFePO4/Li battery assembled with OPAN separator given an outstanding initial discharge specific capacity and coulomb efficiency of 152.1 mAh/g and 97.9% and shown an excellent capacity retention ability of 92.3% after 100 cycles. The battery assembled with OPAN separator exhibits more excellent rate performance than PAN and Celgard 2400 separators at a charge current density of 0.2–3.0 C. It is believed that this excellent separator with such remarkable performances and low cost can be a promising separator candidate for safe LIBs.
hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation
Authors: Milani Gualtiero , Budriesi Roberta , Tavazzani Elisa , Cavalluzzi Maria Maddalena , Mattioli Laura Beatrice , Miniero Daniela Valeria , Delre Pietro , Belviso Benny Danilo , Denegri Marco , Cuocci Corrado , Rotondo Natalie Paola , De Palma Annalisa , Gualdani Roberta , Caliandro Rocco , Mangiatordi Giuseppe Felice , Kumawat Amit , Camilloni Carlo , Priori Silvia , Lentini Giovanni 
Published: July 2023

AbstractLong QT syndrome (LQTS) is a disorder of cardiac electrophysiology resulting in life‐threatening arrhythmias; nowadays, only a few drugs are available for the management of LQTS. Focusing our attention on LQT2, one of the most common subtypes of LQTS caused by mutations in the human ether‐à‐go‐go‐related gene (hERG), in the present work, the stereoselectivity of the recently discovered mexiletine‐derived urea 8 was investigated on the hERG potassium channel. According to preliminary in silico predictions, in vitro studies revealed a stereoselective behavior, with the meso form showing the greatest hERG opening activity. In addition, functional studies on guinea pig isolated left atria, aorta, and ileum demonstrated that 8 does not present any cardiac or intestinal liability in our ex vivo studies. Due to its overall profile, (R,S)‐8 paves the way for the design and development of a new series of compounds potentially useful in the treatment of both congenital and drug‐induced forms of LQTS.
Herausforderungen in der Membranentwicklung für die Fruchtsaftklarfiltration – vom Labor in die Produktion
Authors: Haupt Alexander 
Published: July 2023

AbstractFür die Schönung/Klarfiltration von Apfelsäften wird seit vielen Jahren eine Ultrafiltrations‐Polyethersulfon‐Rohrmembran erfolgreich verwendet. Diese findet bei der Filtration dunkler Fruchtsäfte keine Anwendung, da teilweise auch charakteristische Farbstoffe zurückgehalten werden. Um diesen Markt erschließen zu können, soll eine Rohrhülsenmembran auf PVDF‐Basis entwickelt werden, die dunkle Säfte nicht entfärbt, aber Trübstoffe zurückhält. Dabei werden die Schritte vom allgemeinen Verständnis der Fruchtsaftklarfiltration über Labortests, bis zu ersten Feldtests fertiger Membranmodule kurz beschrieben.
The Steady‐State ALTADENA RASER Generates Continuous NMR Signals
Authors: Yang Jing , Wang Peng , Korvink Jan G. , J. Brandner Jürgen , Lehmkuhl Sören 
Published: July 2023

AbstractThe front cover artwork is provided by Dr. Lehmkuhl's group at the Karlsruhe Institute of Technology. The image shows continuous NMR signals complemented by a simulated bifurcation diagram of a nonlinear RASER system. Read the full text of the Research Article at 10.1002/cphc.202300204.
Introducing Systems Thinking Techniques into an Undergraduate Engineering Education
Authors: Dano Eric B. 
Published: July 2023

AbstractThe world is faced with producing more complex, interdependent systems, and systems of systems. Due to the complexity and interdependencies, these systems do not lend themselves to the traditional reductionist approach, which is feasible only for complicated systems. To architect and develop complex systems requires the use of systems thinking tools and competencies which are an enabler for developing complex engineered systems, humanitarian systems, organizational structures, business strategies, production optimization, solving socio‐technical problems, etc. Because of the power of systems thinking and its global applicability, the question becomes; how can we better produce system thinkers? There are currently many effective systems thinking methods and tools which have been successfully adopted by practicing engineers. This paper will describe how we can introduce similar systems thinking elements into an existing undergraduate education through lectures/mentoring, labs/projects/experiments, case studies/background research, and multi‐discipline capstone projects/internships. Some universities have recently added systems thinking elements to their curricula, and through INCOSE's influence, the Accreditation Board for Engineering and Technology (ABET) now mandates systems thinking for all undergraduate engineering programs. This paper acts to describe a variety of implementation methods to serve as exemplars for those implementing systems thinking into existing curricula. The motivation of this work is to ultimately produce engineers who are better suited to engineering complex systems when they enter the workforce.
System Engineering Heuristics for Complex Systems
Authors: Beale Dean , McKinney Dorothy , Oosthuizen Rudolph , Smith Gary , Watson Michael D. 
Published: July 2023

AbstractComplex systems are challenging for engineers. In considering the challenges in addressing complex problems as well as designing and developing complex systems, the INCOSE Complex Systems Working Group (CSWG) Heuristics Focus Team, in conjunction with the INCOSE Heuristics Team, has considered a range of systems engineering heuristics that guide the engineering of complex systems. These heuristics provide some initial insight for understanding the engineering of complex systems. This work aims to identify, develop, analyze and curate these heuristics and their potential use in dealing with complexity and developing complex systems. This paper concludes that a range of beneficial heuristics have been identified that cover the breadth of complex problems, as assessed from multiple perspectives. This initial or preliminary set of heuristics needs to be tested through practice and use across the INCOSE community before effort is expended to make them more memorable, either individually, or as a set.
From System Architecting to System Design and Optimization: A Link Between MBSE and MDAO
Authors: Bussemaker Jasper , Boggero Luca , Ciampa Pier Davide 
Published: July 2023

AbstractOptimization of system architectures can help deal with finding better system architectures in a large design space plagued by combinatorial explosion of alternatives. To enable architecture optimization, the design space should therefore be formalized into a numerical optimization problem, and it should be possible to quantitatively evaluate architecture alternatives. This paper presents a methodology for generating and modeling architecture design spaces using the Architecture Design Space Graph (ADSG), and using collaborative Multidisciplinary Design Analysis and Optimization (MDAO) techniques to evaluate architectures. Collaborative MDAO leverages disciplinary expertise while ensuring that analysis tools exchange data consistently and correctly using a central data schema. The problem solved in this paper is the missing link between architecture optimization and collaborative MDAO: the reflection of generated architectures in the central data schema. It is solved by the authors by mapping architecture components and Quantities of Interest (QOIs) to the central data schema using Data Schema Operations (DSOs). Such a mapping also assists the user in identifying missing or unnecessary disciplinary analysis tools. Three web‐based software tools implementing the methodology are presented. Finally, the methodology and tools are demonstrated using the design of a supersonic business jet as an example.
Realizing the Promise of Digital Engineering: Planning, Implementing, and Evolving the Ecosystem
Authors: Schindel William D. 
Published: July 2023

AbstractGaining benefits of Digital Engineering is not only about implementing digital technologies. An ecosystem for innovation is a system of systems in its own right, only partly engineered, subject to risks and challenges of evolving socio‐technical systems. This paper summarizes an aid to planning, analyzing, implementing, and improving innovation ecosystems. Represented as a configurable model‐based Reference pattern used by collaborating INCOSE working groups, it was initially applied in targeted INCOSE case studies, and subsequently elaborated and applied to diverse commercial and defense ecosystems. Explicating the recurrent theme of Consistency Management underlying all historical engineering, it is revealing of Digital Engineering's special promise, and enhances understanding of historical as well as future engineering and life cycle management. It includes preparation of human and technical resources to effectively consume and exploit digital information assets, not just create them, capability enhancements over incremental release trains, and evolutionary steering using feedback and group learning.