bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survei Jentik Aedes Sp, Pengetahuan dan Perilaku 3M Plus Masyarakat di Provinsi Jawa Barat
Authors: Veronika Erna , Simatupang Meithyra Melviana , Irfandi Ahmad , Nitami Mayumi 
Published: July 2023

Background of Study: Dengue hemorrhagic fever is caused by the dengue virus which is carried by the Aedes sp mosquito as a vector. Environmental conditions and community behaviour are the factors that influence the spread of this infection. Therefore, the efforts to control DHF in the community are carried out with the movement to eradicate mosquito nests through the 3M Plus program. In 2020, West Java Province recorded the highest cases of DHF in Indonesia, so it was catagorized as red zone and became the dengue endemic area. This study aimed to describe the presence larvae of Aedes sp, the community's knowledge dan behaviour about 3M Plus in West Java ProvinceMethods: This descriptive study used a cross sectional design, conducted in West Java Province in 2020. The sample of this study as many as 136 households and was selected using purposive sampling technique.Results: The results showed that 77.2% of the community's knowledge level of 3M plus was catagorized as good, 51.5% of the people implemented 3M Plus, and no mosquito larvae were found in 72.8% of the respondents' housesConclusion: The majority of the community had good knowledge and had implemented the 3M Plus program with results showing that in most of the community's homes no larvae were found. It is suggested to the community to regularly monitor larvae around their homes.Keywords: Dengue fever; Larva survey; 3M plus; Water container
Method of recurrent truncated-positional coding video segments in uneven diagonal space
Authors: Barannik Vladimir , Shulgin Sergii , Kozlovskyi Valerii , Onyshchenko Roman , Belikova Tatyana , Ihnatiev Oleksandr , Khlopiachyi Viacheslav 
Published: July 2023

The subject of research in this article is methods of encoding transformed video segments to reduce their bit volume without loss of information integrity. The goal is to develop a technology for coding uneven diagonal sequences under the conditions of their arbitrary positioning in the transformant. Task: to justify the approach of creating new methods of encoding video segments, considering the features of the combinatorial configuration of transformants; to create a method of formatting the coordinate system of spectral components in an uneven diagonal direction; to develop a method of encoding non-uniform diagonal sequences in a two-dimensional spectral space; to build a technology for recurrent realization of the process of sliding truncated-positional coding of uneven-diagonal sequences. The methods used are: mathematical models for estimating the number of structural-combinatorial and psychovisual-combinatorial redundancies in an uneven-diagonal spectral space; methods of positional coding. The following results were obtained. Potential advantages of considering the combinatorial configuration of the transformant based on its reformatting according to the non-uniform diagonal structure are substantiated. The technology of recurrent truncated positional coding of video segments in non-uniform diagonal space has been developed. It is based on two technological components. These include: the first component - a pyramidal system of positioning diagonals and their component in the transformant is created. The second component - a method of recurrent implementation of truncated-positional coding of uneven-diagonal sequences, is constructed. Such coding is organized regardless of the positioning of the diagonals in the two-dimensional spectral space of the transformant. Comparative evaluation revealed the advantages of the created method over standardized transformant coding methods. The advantage is achieved by the level of bit volume reduction and reaches an average of 15-30 %. Conclusions. For the first time, a method for establishing the coordinates of the components in the diagonals was developed. It is based on considering the features of the structural configuration of the transformant. This creates conditions for reducing time delays for processing video segments. For the first time, a method for recurrent coding of diagonals based on truncated-positional systems was created. This makes it possible to avoid the cases of the violation of the conditions of mutually unambiguous code conversion.
Statelessness in Canada: socio-political exclusion and the negation of 'stateless persons' human rights
Authors: Moore Lauren Hannah 
Published: July 2023

<p>Given their lack of recognised citizenship and their inability to obtain travel and identification Â documentation, stateless persons are at high risk for both social and political exclusion. Â Consequentially, stateless people experience human rights violations in the forms of; the inability Â to move freely, the use of arbitrary detention, and the denial of access to services that grant Â fundamental rights outlined in the Universal Declaration of Human Rights (1948). Canada does Â not currently have a stateless determination process for identifying statelessness within its law, an Â issue that likely reinforces why statelessness is a highly under-researched issue within Canadian Â academia. This body of work provides an overview of the current state of affairs in Canadian literature, in the form of a literature review. By outlining gaps within Canadian academia, this Â paper provides recommendations for areas of additional research. Doing so ultimately highlights the importance of ensuring all persons are afforded citizenship rights.</p>
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<p>Keywords: Statelessness, Canada, Citizenship, Human Rights, International Obligation, State Sovereignty, Â Securitization, Immigration Detention, International Human Rights Law.Â </p>
Pengaruh Dosis Pupuk Organik Kompos dan Phonska Terhadap Pertumbuhan dan Produksi Tanaman Mentimun (Cucumis sativus L.)
Authors: Extrada Lody Bintang , Supriyono Supriyono , Samudi Samudi 
Published: July 2023

Cucumber (Cucumis sativus L.) is a type of vegetable from the cucurbit family (Cucurbitaceae) that is already popular all over the world. According to history, cucumber plants originated on the Asian continent. Some sources mention the area of origin of cucumber crops is North Asia. This research has been carried out from January to March 2022 at the Green ccHouse located in Slumbung Hamlet RT. 02 / RW. 22 Village. Slumbung Kec. Ngadiluwih Kab. Kediri. The type of soil in this place is sandy loam.This study used a complete randomized design (RAL) with 2 factors. Factor 1 is the influence of the dose of compost from 3 levels and factor 2 is the influence of the dose of phonska fertilizer from 3 levels so that 9 treatments are repeated 3 times, Factor I. Dose of compost organic fertilizer consists of 3 levels, namely: K1 = 5 tons / Ha, K2 = 10 tons / Ha, K3 = 15 tons / Ha, Factor II. The dose of NPK phonska fertilizer consists of 3 levels, namely: P1 = 100 gr / Ha, P2 = 200 gr Ha, P3 = 300 gr / Ha . The observational data were analyzed using a variance analysis (F test) at a level of 5%. If there is an interaction, it is continued with the 5% BNT test, to find out the difference between treatments. The results showed that the combination of treatment of compost doses and doses of NPK phonka fertilizer showed a noticeable difference in plant height, number of fruits and fruit weight in cucumber plants. In a single treatment, the dose of compost did not show any effect on all observation variables. However, the K1 treatment at a dose of 180 gr / plant became the optimal treatment on the variables of the number of leaves stem diameter, fruit weight, and fruit length. However, in the variable plant height and the number of fruits the best treatment in K2 at a dose of 360 gr / plant. The second factor in the treatment of doses of NPK phonska fertilizer has no influence on the growth and yield of cucumber plants. However, in mite treatment such as npk dose phoska P2 with a dose of 7.2gr / plant became the optimal treatment in this study on plant growth variables that followed the length of the plant, the number of leaves and the diameter of the stem. Meanwhile, the yield variables which include the number of fruits, fruit weight and fruit length of the NPK phonska treatment at a dose of 10.8gr / plant is the best treatment.
A Magyar Pedagógiai Társaság Szakképzési Kollégiuma által szervezett ”Beszélgetések a szakképzésről”
Authors: Schindler Rózsa 
Published: July 2023

2023-as évindító a duális szakképzés megvalósításában jelentős szerepet vállaló, a szakképzés együttműködési rendszerének egyik meghatározó szereplője, az Ágazati Készségtanácsoknak, mint a szakképzés tartalmi szerkezetének folyamatos fejlesztését és korszerűsítését, a munkaerő-piaci igények és a képzési kínálat összehangolásáért felelős irányító szervezet megismerésének lehetősége adta.
Neurotrophin-4 promotes the specification of trophectoderm lineage after parthenogenetic activation and enhances porcine early embryonic development
Authors: Kim Mirae , Lee Joohyeong , Cai Lian , Choi Hyerin , Oh Dongjin , Jawad Ali , Hyun Sang-Hwan 
Published: July 2023

Neurotrophin-4 (NT-4), a neurotrophic factor, appears to affect early embryonic development because it is secreted not only by neurons but also by oviductal and uterine epithelial cells. However, no studies have characterized the effects of NT-4 on early embryonic development in pigs. In this study, we applied the experimental model of parthenogenetic-activation (PA)-derived embryos. Herein, we investigated the effect of NT-4 supplementation during the in vitro culture (IVC) of embryos, analyzed the transcription levels of specific genes, and outlined the first cell lineage specification for porcine PA-derived blastocysts. We confirmed that NT-4 and its receptor proteins were localized in both the inner cell mass (ICM) and trophectoderm (TE) in porcine blastocysts. Across different concentrations (0, 1, 10, and 100 ng/mL) of NT-4 supplementation, the optimal concentration of NT-4 to improve the developmental competence of porcine parthenotes was 10 ng/mL. NT-4 supplementation during porcine IVC significantly (p &lt; 0.05) increased the proportion of TE cells by inducing the transcription of TE lineage markers (CDX2, PPAG3, and GATA3 transcripts). NT-4 also reduced blastocyst apoptosis by regulating the transcription of apoptosis-related genes (BAX and BCL2L1 transcripts) and improved blastocyst quality via the interaction of neurotrophin-, Hippo-yes-associated protein (Hippo-YAP) and mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway. Additionally, NT-4 supplementation during IVC significantly (p &lt; 0.05) increased YAP1 transcript levels and significantly (p &lt; 0.01) decreased LATS2 transcript levels, respectively, in the porcine PA-derived blastocysts. We also confirmed through fluorescence intensity that the YAP1 protein was significantly (p &lt; 0.001) increased in the NT-4-treated blastocysts compared with that in the control. NT-4 also promoted differentiation into the TE lineage rather than into the ICM lineage during porcine early embryonic development. In conclusion, 10 ng/mL NT-4 supplementation enhanced blastocyst quality by regulating the apoptosis- and TE lineage specification-related genes and interacting with neurotrophin-, Hippo-YAP-, and MAPK/ERK signaling pathway during porcine in vitro embryo development.
Unravelling potential biomarkers for acute and chronic brucellosis through proteomic and bioinformatic approaches
Authors: Yang Yuejie , Qiao Kunyan , Yu Youren , Zong Yanmei , Liu Chang , Li Ying 
Published: July 2023

IntroductionThis study aimed to identify biomarkers for acute and chronic brucellosis using advanced proteomic and bioinformatic methods.MethodsBlood samples from individuals with acute brucellosis, chronic brucellosis, and healthy controls were analyzed. Proteomic techniques and differential expression analysis were used to identify differentially expressed proteins. Co-expression modules associated with brucellosis traits were identified using weighted gene co-expression network analysis (WGCNA).Results763 differentially expressed proteins were identified, and two co-expression modules were found to be significantly associated with brucellosis traits. 25 proteins were differentially expressed in all three comparisons, and 20 hub proteins were identified. Nine proteins were found to be both differentially expressed and hub proteins, indicating their potential significance. A random forest model based on these nine proteins showed good classification performance.DiscussionThe identified proteins are involved in processes such as inflammation, coagulation, extracellular matrix regulation, and immune response. They provide insights into potential therapeutic targets and diagnostic biomarkers for brucellosis. This study improves our understanding of brucellosis at the molecular level and paves the way for further research in targeted therapies and diagnostics.
Renal perfusion improvement in the perioperative period after unilateral endovascular revascularization in patients with atherosclerotic renal artery stenosis
Authors: Xu Leyin , Shao Jiang , Li Kang , Wang Chaonan , Lai Zhichao , Ma Jiangyu , Yu Xiaoxi , Du Fenghe , Chen Junye , Liu Xiaolong , Yuan Jinghui , Liu Bao , Wang Chunyang 
Published: July 2023

BackgroundThe clinical benefits of endovascular treatment in renal artery stenosis (RAS) remain controversial. This study used an intraoperative renal perfusion imaging technique, called flat-panel detector parenchymal blood volume imaging (FD-PBV), to observe the change in renal perfusion after endovascular treatment in RAS.Materials and methodsIn a prospective, single-center study, we assigned 30 patients with atherosclerotic RAS who underwent endovascular treatment between March 2016 and March 2021. The preoperative and postoperative results of renal perfusion, blood pressure, and renal function, were compared.ResultsBoth median kidney volume (p &lt; 0.001) and median preoperative mean density of contrast medium (MDCM) (p = 0.028) increased significantly after endovascular treatment. The ratio of postoperative and preoperative MDCM differed greatly among the patients. For patients with preoperative MDCM &lt;304.0 HU (Subgroup A, 15 cases), MDCM significantly increased after treatment (p = 0.001) and 12 (80.0%) patients had more than 10% increase in renal perfusion. For patients who had relatively high preoperative renal perfusion (MDCM ≥304.0 HU, Subgroup B, 15 cases), preoperative and postoperative MDCM were similar (p = 0.776). On the other hand, the serum creatinine levels significantly decreased in Subgroup A (p = 0.033) and fewer antihypertensive drugs were used after endovascular revascularization (p = 0.041). The preoperative and postoperative creatinine levels and number of antihypertensive drugs were similar in Subgroup B.ConclusionsDuring the perioperative period, RAS patients with relatively low preoperative renal perfusion levels had greater improvement in renal perfusion, renal function, and blood pressure control after endovascular treatment. The improvement of renal function needs to be confirmed by long-term follow-up.
A self-controlled, cross-over study of intensive insulin treatment with needle-based injection versus needle-free injection in hospitalized patients with type 2 diabetes
Authors: Wu Quanying , Deng Mingqun , Wang Weihao , Yu Shuyi , Wang Miao , Sun Chao , Pan Qi , Guo Lixin 
Published: July 2023

Background and AimsNeedle injection and needle-free injection were proven effective in improving glycated hemoglobin (HbA1c) in type 2 diabetes mellitus (T2DM) patients. However, it is unclear if needle-free and needle injections of insulin during intensive insulin therapy in hospitalized patients provide similar efficacy and safety benefits.MethodsA self-controlled cross-over study was conducted on 62 patients with T2DM who received intensive long-acting and short-acting insulin injections with or without needles. The 7-point blood glucose test was performed on the 6th day after insulin administration and the injection method switched on the 7th day of hospitalization. The difference was compared in 7-point blood glucose levels.ResultsThe blood glucose levels at fasting (mean difference=-1.09 ± 2.38mmol/L, 95% CI, -1.69 to -0.48, p=0.0007) and post-breakfast (-1.14 ± 3.02mmol/L, 95%CI, -1.91 to -0.37, p=0.004) were better when patients were receiving needle-free injections compared to when receiving a needle injection. Indeed, daily blood glucose fluctuation, which presented as the area under the curve of glycemia, was decreased in needle-free injection periods (-0.3.48 ± 9.64, 95%CI, -5.95 to -1.01, p=0.0065). There was no significant difference in the dose of long-acting insulin between the two injection methods (-0.32 ± 2.69, 95%CI, -0.99 to 0.37, p&gt;0.05). The dose of fast-acting insulin during the needle-free period was lower than that of when patients received needle injections (-1.66 ± 6.45, 95%CI, -3.29 to -0.025, p&lt;0.05). There was no significant difference in satisfaction between the two regimens (-0.59 ± 1.55,95%CI, -0.938 to 0.509, p=0.557), but there was a significant difference in pain experience, favoring needle-free injections (p &lt; 0.001).ConclusionGlycemia was better controlled by needle-free insulin injections in hospitalized T2DM patients subjected to intensive glycemic control. These patients also experienced less pain than when insulin was injected with a needle.
Developing high-resolution PM2.5 exposure models by integrating low-cost sensors, automated machine learning, and big human mobility data
Authors: Yu Manzhu , Zhang Shiyan , Zhang Kai , Yin Junjun , Varela Matthew , Miao Jiheng 
Published: July 2023

Introduction: Traditional methods to estimate exposure to PM2.5 (particulate matter with less than 2.5 µm in diameter) have typically relied on limited regulatory monitors and do not consider human mobility and travel. However, the limited spatial coverage of regulatory monitors and the lack of consideration of mobility limit the ability to capture actual air pollution exposure.Methods: This study aims to improve traditional exposure assessment methods for PM2.5 by incorporating the measurements from a low-cost sensor network (PurpleAir) and regulatory monitors, an automated machine learning modeling framework, and big human mobility data. We develop a monthly-aggregated hourly land use regression (LUR) model based on automated machine learning (AutoML) and assess the model performance across eight metropolitan areas within the US.Results: Our results show that integrating low-cost sensor with regulatory monitor measurements generally improves the AutoML-LUR model accuracy and produces higher spatial variation in PM2.5 concentration maps compared to using regulatory monitor measurements alone. Feature importance analysis shows factors highly correlated with PM2.5 concentrations, including satellite aerosol optical depth, meteorological variables, vegetation, and land use. In addition, we incorporate human mobility data on exposure estimates regarding where people visit to identify spatiotemporal hotspots of places with higher risks of exposure, emphasizing the need to consider both visitor numbers and PM2.5 concentrations when developing exposure reduction strategies.Discussion: This research provides important insights for further public health studies on air pollution by comprehensively assessing the performance of AutoML-LUR models and incorporating human mobility into considering human exposure to air pollution.
LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer
Authors: Kołat Damian , Kałuzińska-Kołat Żaneta , Kośla Katarzyna , Orzechowska Magdalena , Płuciennik Elżbieta , Bednarek Andrzej K. 
Published: July 2023

Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions. WWOX is a global gene expression modulator that is scarcely investigated for its role in regulating cancer-related ncRNAs. In bladder cancer (BLCA), the link between WWOX and ncRNA remains unexplored. The description of AP-2α and AP-2γ transcription factors, known as WWOX-interacting proteins, is more commonplace regarding ncRNA but still merits investigation. Therefore, this in vitro and in silico study aimed to construct an ncRNA-containing network with WWOX/AP-2 and to investigate the most relevant observation in the context of BLCA cell lines and patients.Methods: RT-112, HT-1376, and CAL-29 cell lines were subjected to two stable lentiviral transductions. High-throughput sequencing of cellular variants (deposited in the Gene Expression Omnibus database under the GSE193659 record) enabled the investigation of WWOX/AP-2-dependent differences using various bioinformatics tools (e.g., limma-voom, FactoMineR, multiple Support Vector Machine Recursive Feature Elimination (mSVM-RFE), miRDB, Arena-Idb, ncFANs, RNAhybrid, TargetScan, Protein Annotation Through Evolutionary Relationships (PANTHER), Gene Transcription Regulation Database (GTRD), or Evaluate Cutpoints) and repositories such as The Cancer Genome Atlas (TCGA) and Cancer Cell Line Encyclopedia. The most relevant observations from cap analysis gene expression sequencing (CAGE-seq) were confirmed using real-time PCR, whereas TCGA data were validated using the GSE31684 cohort.Results: The first stage of the whole study justified focusing solely on WWOX rather than on WWOX combined with AP-2α/γ. The most relevant observation of the developed ncRNA-containing network was LINC01137, i.e., long non-coding RNAs (lncRNAs) that unraveled the core network containing UPF1, ZC3H12A, LINC01137, WWOX, and miR-186-5p, the last three being a novel lncRNA/miRNA/mRNA axis. Patients’ data confirmed the LINC01137/miR-186-5p/WWOX relationship and provided a set of dependent genes (i.e., KRT18, HES1, VCP, FTH1, IFITM3, RAB34, and CLU). Together with the core network, the gene set was subjected to survival analysis for both TCGA-BLCA and GSE31684 patients, which indicated that the increased expression of WWOX or LINC01137 is favorable, similar to their combination with each other (WWOX↑ and LINC01137↑) or with MIR186 (WWOX↑/LINC01137↑ but MIR186↓).Conclusion: WWOX is implicated in the positive feedback loop with LINC01137 that sponges WWOX-targeting miR-186-5p. This novel WWOX-containing lncRNA/miRNA/mRNA axis should be further investigated to depict its relationships in a broader context, which could contribute to BLCA research and treatment.