bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum information geometry of driven CFTs
Authors: de Boer Jan , Godet Victor , Kastikainen Jani , Keski-Vakkuri Esko 
Published: September 2023

Abstract
Driven quantum systems exhibit a large variety of interesting and sometimes exotic phenomena. Of particular interest are driven conformal field theories (CFTs) which describe quantum many-body systems at criticality. In this paper, we develop both a spacetime and a quantum information geometry perspective on driven 2d CFTs. We show that for a large class of driving protocols the theories admit an alternative but equivalent formulation in terms of a CFT defined on a spacetime with a time-dependent metric. We prove this equivalence both in the operator formulation as well as in the path integral description of the theory. A complementary quantum information geometric perspective for driven 2d CFTs employs the so-called Bogoliubov-Kubo-Mori (BKM) metric, which is the counterpart of the Fisher metric of classical information theory, and which is obtained from a perturbative expansion of relative entropy. We compute the BKM metric for the universal sector of Virasoro excitations of a thermal state, which captures a large class of driving protocols, and find it to be a useful tool to classify and characterize different types of driving. For Möbius driving by the SL(2, ℝ) subgroup, the BKM metric becomes the hyperbolic metric on the disk. We show how the non-trivial dynamics of Floquet driven CFTs is encoded in the BKM geometry via Möbius transformations. This allows us to identify ergodic and non-ergodic regimes in the driving. We also explain how holographic driven CFTs are dual to driven BTZ black holes with evolving horizons. The deformation of the black hole horizon towards and away from the asymptotic boundary provides a holographic understanding of heating and cooling in Floquet CFTs.
Neutrino oscillation bounds on quantum decoherence
Authors: De Romeri Valentina , Giunti Carlo , Stuttard Thomas , Ternes Christoph A. 
Published: September 2023

Abstract
We consider quantum-decoherence effects in neutrino oscillation data. Working in the open quantum system framework we adopt a phenomenological approach that allows to parameterize the energy dependence of the decoherence effects. We consider several phenomenological models. We analyze data from the reactor experiments RENO, Daya Bay and KamLAND and from the accelerator experiments NOvA, MINOS/MINOS+ and T2K. We obtain updated constraints on the decoherence parameters quantifying the strength of damping effects, which can be as low as Γij ≲ 8 × 10−27 GeV at 90% confidence level in some cases. We also present sensitivities for the future facilities DUNE and JUNO.
Making un/equal: reassessing inequality and mental health through a praxeographic approach on welfare categorization processes
Authors: Bister Milena D. 
Published: September 2023

Abstract
Purpose
In recent decades, Europe has seen a steady increase in psychiatric diagnoses, which, besides affecting the population in many ways, also challenges the organization of welfare. This paper explores how welfare classification processes impact the contemporary production of mental (ill) health and social inequality in the German welfare state.

Methods
Based on comprehensive ethnographic research in the public mental healthcare landscape in Berlin between 2011 and 2017, this paper discusses in detail the case of a mandatory prescription of a psychosocial rehabilitation measure for Ms Reisch, a psychiatric service user and ethnographic research partner. The analysis draws on the methodological approach of praxeography to examine how this case challenges the social determinants of mental health framework and the conceptual work of the sociology of inequality on which the categories of welfare are largely built.

Results
The paper highlights the essentializing properties of social categories, whether in the sociology of inequality or in social and mental health policy. It also demonstrates the strength of praxeography to expose how multiple welfare categorization processes shape experiences and events of dis/ability in practice, potentially contradicting the stated intentions of social policy.

Conclusion
The results suggest that the attachment of categories to people in public welfare needs to be changed to make public administration more flexible to responding to the situated processes that bring about differentiations of equal and unequal in practice. The paper, therefore, encourages social inquiry into the potentialities of a post-categorical social policy framework.
Revealed statistical consumer theory
Authors: Allen Roy , Dziewulski Paweł , Rehbeck John 
Published: September 2023

AbstractWe provide a microfoundation to use aggregates (e.g. mean purchases) to evaluate consumer choice data. We study statistical consumer theory where an individual maximizes a preference over distributions of bundles when constrained by a statistic of the distribution (e.g. mean expenditure). We show statistical consumer theory is observationally equivalent to an individual whose preferences depend only on the statistic of the distribution. This means that despite working with distributions, the empirical content of the model only depends on a finite-dimensional statistic. This approach generalizes random quasilinear utility with random income and mean-variance preferences.
Strichartz estimates for the half wave/Klein–Gordon and Dirac equations on compact manifolds without boundary
Authors: Cacciafesta Federico , Danesi Elena , Meng Long 
Published: September 2023

AbstractIn this paper we study Strichartz estimates for the half wave, the half Klein–Gordon and the Dirac Equations on compact manifolds without boundary, proving in particular for each of these flows local in time estimates both for the wave and Schrödinger admissible couples (in this latter case with an additional loss of regularity). The strategy for the proof is based on a refined version of the WKB approximation.
Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay
Authors: Kopra Kari , Mahran Randa , Yli-Hollo Titta , Tabata Sho , Vuorinen Emmiliisa , Fujii Yuki , Vuorinen Iida , Ogawa-Iio Aki , Hirayama Akiyoshi , Soga Tomoyoshi , Sasaki Atsuo T. , Härmä Harri 
Published: September 2023

AbstractGuanosine triphosphate (GTP) and adenosine triphosphate (ATP) are essential nucleic acid building blocks and serve as energy molecules for a wide range of cellular reactions. Cellular GTP concentration fluctuates independently of ATP and is significantly elevated in numerous cancers, contributing to malignancy. Quantitative measurement of ATP and GTP has become increasingly important to elucidate how concentration changes regulate cell function. Liquid chromatography–coupled mass spectrometry (LC–MS) and capillary electrophoresis-coupled MS (CE–MS) are powerful methods widely used for the identification and quantification of biological metabolites. However, these methods have limitations related to specialized instrumentation and expertise, low throughput, and high costs. Here, we introduce a novel quantitative method for GTP concentration monitoring (GTP-quenching resonance energy transfer (QRET)) in homogenous cellular extracts. CE–MS analysis along with pharmacological control of cellular GTP levels shows that GTP-QRET possesses high dynamic range and accuracy. Furthermore, we combined GTP-QRET with luciferase-based ATP detection, leading to a new technology, termed QT-LucGTP&ATP, enabling high-throughput compatible dual monitoring of cellular GTP and ATP in a homogenous fashion. Collectively, GTP-QRET and QT-LucGTP&ATP offer a unique, high-throughput opportunity to explore cellular energy metabolism, serving as a powerful platform for the development of novel therapeutics and extending its usability across a range of disciplines.
Graphical Abstract
An update and overview of the literature on late inflammatory reactions (LIRs) in soft tissue fillers after SARS-CoV-2 infection and vaccination
Authors: Bachour Yara 
Published: September 2023

Abstract
Introduction
Soft tissue fillers are widely used and are commonly considered to be safe. Nonetheless, adverse events such as late inflammatory reactions (LIRs) are reported for every type of filler. As of the start of the COVID-19 pandemic, LIRs have been reported after SARS-CoV infection or vaccination. In the past, we reviewed these adverse events; however, since then, we faced a wave with the Omicron, and the vaccination programs continued with booster vaccines. We therefore aimed to perform an up-to-date review of the literature on LIRs after COVID-19 infection and vaccination with additional learned lessons from this pandemic.

Material and methods
We performed a systematic review on soft tissue filler-related LIRs after SARS-CoV-2 infection or vaccination in line with the PRISMA guidelines. Eligible studies were searched in the database PubMed from 1 August 2021 until 1 June 2023. Data on patient characteristics, filler characteristics, clinical findings, and treatment options were retrieved.

Results
A total of 14 papers with in total 52 patients were reported, of which 16 had adverse events after a SARS-CoV-2 infection and 36 after SARS-CoV-2 vaccination. In most cases, it concerned females who had their (mostly temporary) fillers for cosmetic purposes. Symptoms were reported in a matter of hours up to weeks after SARS-CoV-2 vaccination (22 Pfizer, 7 Moderna, 3 AstraZeneca, 3 Sputnik V, and one after Siophram), mostly after the first or second dose but sporadically after a third dose. Most patients were treated in a conservative manner.

Discussion
LIRs continue to be reported after SARS-CoV-2 infection and vaccination and are currently also reported for non-mRNA vaccines, for non-temporary fillers, and also after a third dose of the vaccine. Although there are more and more papers on this matter, they remain minor and self-limiting. We therefore still advise patients with soft tissue fillers to remain participated in vaccination programs when needed.
Level of evidence: Not gradable.
Learning Curve for Thoracoscopic Individual Basilar Segmentectomy: 18‐Year Experience
Authors: Takamori Satoshi , Oizumi Hiroyuki , Suzuki Jun , Watanabe Hikaru , Sato Kaito , Shiono Satoshi , Sho Ri 
Published: September 2023

AbstractBackgroundThoracoscopic anatomical individual basilar segmentectomy remains challenging owing to the deep intraparenchymal location of the hilar structures and anatomical variations. We analyzed and reported the experience and progress of thoracoscopic anatomical individual basilar segmentectomy at our university hospital.MethodsWe retrospectively examined the patients who underwent anatomical basilar segmentectomy at our institution from January 2004 to December 2021. We divided our analysis period into two parts: the first period (2004–2012) was the introductory period of video‐assisted thoracoscopic surgery (VATS) segmentectomy, and the second period (2013–2021) was the maturity period of VATS segmentectomy. The learning curve of the leading surgeon in the second period was also evaluated based on the operative time and cumulative sum value of the operative time.ResultsOverall, 127 cases were evaluated, among whom 33 and 94 cases were assessed during the introductory and maturity periods of thoracoscopic segmentectomy, respectively. Age (P = 0.003) and Charlson comorbidity index (P = 0.002) were higher in the second period than in the first period. Use of a uniport (P = 0.006) was higher, and postoperative hospitalization duration (P =  < 0.001) and operative time (P = 0.024) were shorter in the second period than in the first period. A learning curve obtained during the maturity period showed: The inflection point for the learning curve of thoracoscopic basilar segmentectomy was reached after 42 cases.ConclusionsWe have demonstrated a single institution’s progress and learning curve for difficult segmentectomies. This may be helpful to institutions considering performing this surgery.
Intravenous or subcutaneous natalizumab in patients with relapsing–remitting multiple sclerosis: investigation on efficiency and savings—the EASIER study
Authors: Filippi Massimo , Grimaldi Luigi , Conte Antonella , Totaro Rocco , Valente Maria Rosaria , Malucchi Simona , Granella Franco , Cordioli Cinzia , Brescia Morra Vincenzo , Zanetta Chiara , Perini Daria , Santoni Laura ,   the EASIER Study Working Group, Ziccone V. , Garba R. , Motta A. , Albanesi S. , Oddo O. , Impagliato A. , Ferrazzano G. , Di Rosa V. , Tartaglia M. , Di Vito A. , Galassi A. , Prota R. , Garbo R. , Del Negro I. , Nesi L. , Capobianco M. , Tsantes E. , Agosta R. , Valleri A. M. , Galuppini L. , Mascara S. , Bertocchi F. , Chiarini E. , Moccia M. , Puorro G. 
Published: September 2023

Abstract
Introduction
EASIER is a multicenter, observational, cross-sectional study investigating the consumption of healthcare resources, including healthcare professional (HCP) active working time, the costs associated with the current natalizumab intravenous (IV) administration, and the potential impact of the adoption of subcutaneous (SC) route.

Methods
The EASIER study has three parts: (1) time and motion study to measure healthcare resources and working time needed for natalizumab IV administration using a digital data collection tool operated directly by HCPs; (2) HCP structured questionnaire-based estimation of the potential impact of natalizumab SC vs. IV administration; and (3) patient survey on the burden of natalizumab administration.

Results
Nine Italian multiple sclerosis (MS) centers measured 404 IV natalizumab administration procedures and administered 26 HCP questionnaires and 297 patient questionnaires. Patients had a mean of 52 (range 1–176) previous IV administrations and spent a mean (median, IQR) of 152 (130, 94–184) minutes in the center per each IV procedure, with IV infusion covering 50% of the total. Including patient travel time, an average of 5 h was dedicated to each IV administration. Active working time by HCP amounted to 29 min per IV administration procedure, 70% of which by nursing staff.
With adoption of the SC route, HCPs estimated a 50% reduction in patient procedure time and 55% lower HCP active working time. This translated into a 63% cost reduction for the MS center per natalizumab administration procedure.

Conclusions
SC natalizumab administration will consistently reduce consumption of patient and HCP times per procedure and associated costs.
Stability of delaminated composite beams subjected to retarded periodic follower force
Authors: Szekrényes András 
Published: September 2023

AbstractThis work deals with the stability problem of elastic composite cantilever beams subjected to a delayed, periodically changing follower force. The equation of motion of the periodic system with time delay is deduced based on some previous works. Composite beams with and without delamination are considered, and the finite element method is applied to carry out the spatial discretization of the structures. Besides, for the delaminated case further two cases are involved. The first case is when the delamination is in the midplane of the beam, while the second case involves an asymmetrically placed delamination, respectively. The Floquet theory is applied to derive the transition matrix of the periodic system. An important aspect is that the time delay and the principal period of the dynamic force are equal to each other. The discretization over the time domain is performed by using the Chebyshev polynomials of the first kind. Basically, there are five parameters governing the dynamic problem including among others the time delay and the static and dynamic forces. The stability behavior is shown for the intact and delaminated beams on the parameter planes for large number of cases by using the unit circle criteria. The presence and absence of structural damping is also analyzed in each case. The results indicate that some planes are sensitive to the mesh resolution, others are not. Moreover, on some planes significant differences may take place between the intact and delaminated beams from the standpoint of stable zones.
The role of potassium in depth profiling of the tumor border in bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS): a pilot study
Authors: Winnand Philipp , Boernsen K. Olaf , Ooms Mark , Heitzer Marius , Lammert Matthias , Eschweiler Jörg , Hölzle Frank , Modabber Ali 
Published: September 2023

Abstract
Purpose
Microscopic tumor spread beyond the macroscopically visible tumor mass in bone represents a major risk in surgical oncology, where the spatial complexity of bony resection margins cannot be countered with rapid bone analysis techniques. Laser-induced breakdown spectroscopy (LIBS) has recently been introduced as a promising option for rapid bone analysis. The present study aimed to use LIBS-based depth profiling based on electrolyte disturbance tracking to evaluate the detection of microscopic tumor spread in bone.

Methods
After en bloc resection, the tumor-infiltrated mandible section of a patient’s segmental mandibulectomy specimen was natively investigated using LIBS. Spectral and electrolytic depth profiles were analyzed across 30 laser shots per laser spot position in healthy bone and at the tumor border. For the histological validation of the lasered positions, the mandibular section was marked with a thin separating disc.

Results
Solid calcium (Ca) from hydroxyapatite and soluble Ca from dissolved Ca can be reliably differentiated using LIBS and reflect the natural heterogeneity of healthy bone. Increased potassium (K) emission values in otherwise typically healthy bone spectra are the first spectral signs of tumorous bone invasion. LIBS-based depth profiles at the tumor border region can be used to track tumor-associated changes within the bone with shot accuracy based on the distribution of K.

Conclusion
Depth profiling using LIBS might enable the detection of microscopic tumor spread in bone. In the future, direct electrolyte tracking using LIBS should be applied to other intraoperative challenges in surgical oncology to advance rapid bone analysis by spectroscopic–optical techniques.
Assessing suffering of patients on cancer treatment and of those no longer treated using ESAS–Total Care (TC)
Authors: Miccinesi Guido , Ripamonti Carla , Leoni Silvia , Gandelli Monica , Di Pede Patricia , Visani Vania , Ambrosini Paolo , De Feo Giulia , Bellandi Laura , Toffolatti Luisa , Chelazzi Cosimo , Trinci Consuelo , Chiesi Francesca 
Published: September 2023

Abstract
Aim
The aim of the study was to assess the suffering of patients on oncologic treatment and of those no longer on treatment. Preliminarily, we aimed to confirm the psychometric properties of Edmonton Symptom Assessment System–Total Care (ESAS-TC) in different stages of the disease. The ESAS-TC screens physical and psychological symptoms, but also spiritual pain, discomfort deriving from financial problems associated with illness, and suffering related to social isolation.

Methods
A sample of consecutive advanced cancer patients on oncologic therapies treated at the Internistic and Geriatric Supportive Care Unit (IGSCU) of Istituto Nazionale dei Tumori, Milano, and of terminal patients no longer on treatment and cared for by the Fondazione ANT palliative home care team were asked to fill the ESAS-TC. In order to strengthen the previous validation study of the ESAS-TC, 3-ULS (to assess social isolation), JSWBS (to assess spiritual well-being), COST-IT (to assess financial distress), and KPS (to assess functional status) were administered too.

Results
The questionnaires were self-reported by 108 patients on treatment (52% >60 years old, female 53%, and 61% with KPS 90–100) and by 94 home care patients (71% >60 years old, female 51%, and 68% with KPS 10–50). The sound psychometric characteristics of ESAS-TC were confirmed. Patients on treatment showed lower total ESAS-TC score (19.3 vs 52.7, p<.001) after controlling for age and functional status, and lower financial distress (p.<001). Financial distress, spiritual suffering, and social isolation, after controlling for age, showed a significantly higher score in home care patients.

Conclusions
Only through an adequate routine assessment with validated tools is it possible to detect total suffering, the “Total pain” of patients, and treat it through a multidisciplinary approach. The study confirms the reliability and validity of the Italian version of ESAS-TC and the importance of supportive and early palliative care fully integrated with oncological treatment.
Visualizations for universal deep-feature representations: survey and taxonomy
Authors: Skopal Tomáš , Peška Ladislav , Hoksza David , Sixtová Ivana , Bernhauer David 
Published: September 2023

AbstractIn data science and content-based retrieval, we find many domain-specific techniques that employ a data processing pipeline with two fundamental steps. First, data entities are represented by some visualizations, while in the second step, the visualizations are used with a machine learning model to extract deep features. Deep convolutional neural networks (DCNN) became the standard and reliable choice. The purpose of using DCNN is either a specific classification task or just a deep feature representation of visual data for additional processing (e.g., similarity search). Whereas the deep feature extraction is a domain-agnostic step in the pipeline (inference of an arbitrary visual input), the visualization design itself is domain-dependent and ad hoc for every use case. In this paper, we survey and analyze many instances of data visualizations used with deep learning models (mostly DCNN) for domain-specific tasks. Based on the analysis, we synthesize a taxonomy that provides a systematic overview of visualization techniques suitable for usage with the models. The aim of the taxonomy is to enable the future generalization of the visualization design process to become completely domain-agnostic, leading to the automation of the entire feature extraction pipeline. As the ultimate goal, such an automated pipeline could lead to universal deep feature data representations for content-based retrieval.
Stacking host resistance genes to control Globodera pallida populations with different virulence
Authors: Price James , Preedy Katharine , Young Vanessa , Todd Drummond , Blok Vivian C. 
Published: September 2023

AbstractPotato Cyst Nematodes (PCN) are a globally important and economically extremely damaging potato pest. Chemical control has limited impact and cannot clear a field of PCN, but genetic resistance in potatoes is an effective and important part of natural management of PCN. There are two closely related species of PCN; Globodera rostochiensis against which the H1 resistance gene from S. tuberosum ssp. andigena (CPC 1673) has proven effective in Europe for several decades, and G. pallida for which potato varieties with resistance are also commercially available. However, G. pallida resistant genotypes are mainly limited to processing varieties and most varieties grown are still susceptible to the species. The limited number of suitable varieties with resistance against G. pallida has led to its spread throughout the UK and now infestations in Scottish seed land are threatening the future of potato seed production. Novel potato genotypes with resistance against G. pallida sometimes combine PCN resistances from more than one parental source. Multiplication of a panel of G. pallida populations which differ in virulence against host species were compared on recently developed breeding lines with single or stacked resistance genes. Potato genotypes with multiple resistance genes show reduced multiplication in G. pallida pathotypes that were able to overcome a single resistance gene.