bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNORD11B-mediated 2′-O-methylation of primary let-7a in colorectal carcinogenesis
Authors: Pan Qiuhui , Bian Zhixuan , Xu Chang , Wang Xiaoying , Chen Yan , Mao Siwei , Wu Qi , Zhu Jiabei , Huang Nan , Zhang Yue , Ma Ji , Sun Fenyong 
Published: March 2023

Abstract
Evidence indicates that small nucleolar RNAs (snoRNAs) participate in tumorigenesis and development and could be promising biomarkers for colorectal cancer (CRC). Here, we examine the profile of snoRNAs in CRC and find that expression of SNORD11B is increased in CRC tumor tissues and cell lines, with a significant positive correlation between SNORD11B expression and that of its host gene NOP58. SNORD11B promotes CRC cell proliferation and invasion and inhibits apoptosis. Mechanistically, SNORD11B promotes the processing and maturation of 18S ribosomal RNA (rRNA) by mediating 2'-O-methylated (Nm) modification on the G509 site of 18S rRNA. Intriguingly, SNORD11B mediates Nm modification on the G225 site of MIRLET7A1HG (pri-let-7a) with canonical motif, resulting in degradation of pri-let-7a, inhibition of DGCR8 binding, reduction in mature tumor suppressor gene let-7a-5p expression, and upregulation of downstream oncogene translation. SNORD11B performs better than CEA and CA199 in diagnosing CRC. High expression of SNORD11B is significantly correlated with more advanced TNM stage and lymph node metastasis, which indicate poor prognosis.
Doped CeO 2 /Water Nanofluids Analyzed the performance of Thermal Conductivity and Heat Transfer: An Experimental and Theoretical Investigations
Authors: Pandey Abhishek Kumar , Tiwari Arun Kumar , Paliwal H. K. 
Published: March 2023

Abstract
A combined experimental and theoretical study on thermal conductivity, heat transfer specific heat, and electronic properties has been done for doped CeO2/water nanofluid. First, the sol-gel method was implemented for the synthesis of doped CeO2 nanoparticles and then a mixture of nanoparticles with different water concentrations (i.e. 0.5%,1%, 1.5%) in the form of nanofluid. X-ray diffraction and SEM analysis confirm the structural phase purity and homogeneous mixing of nanofluids. Experimental Thermal conductivity and specific heat of pure and 4f-doped CeO2 were estimated and found very close to our theoretical calculations. Experimental investigations have been carried out for the measurement of heat transfer using pure and doped CeO2/water nanofluid as the coolant. The experiments were aimed at determining the heat transfer and other thermal properties with different concentrations (0.5, 1.0, and 1.5 vol. %) and with various fluid flow rates (1.0 and 3.0 lpm). The heat transfer coefficient of nanofluids increases not only with an increase in the volume flow rate of the hot water but also increases with increase in the atomic number of dopant elements in CeO2. Electronic states show variation in band gap with doping which may also play an important role in the improvement of solar collectors. It is clear from experimental and theoretical findings that the thermal and electronic properties depend on number of valance electrons. Hence doping of 4f-element in CeO2 plays a vital role to increase the thermal conductivity and tunning of electronic properties leads to many applications in thermal sensors and solar cell-based industries.
On the Sequences of $(q,k)$-Generalized Fibonacci Numbers
Authors: Lelis Jean , Freitas Gersica , Kreutz Alessandra , Silva Elaine 
Published: March 2023

Abstract
In this paper, we consider the new family of recurrence sequences of (q,k)-generalized Fibonacci numbers. These sequences naturally extend the well-known sequences of k-generalized Fibonacci numbers and generalized k-order Pell numbers. We shall obtain a Binet-style formula and study the asymptotic behavior of dominant root of characteristic equation. Moreover, we shall prove some auxiliary results about these sequences. In particular, we characterize the first (q,k)-generalized Fibonacci numbers in terms of binary sequences.
Knowledge mapping and current trends of global research on snoRNA in the field of cancer
Authors: Xu Runsen , Hou Junhui , Wang Xia , Wang Yuan , Wang Kefeng 
Published: March 2023

Abstract
Backgroud:

Cancer is a major hazard to human health. Recently, small nucleolar RNA (snoRNA) has been found to be involved in the occurrence and development of cancer, which has potential diagnostic, prognostic and therapeutic value. The purpose of this study is to use the bibliometrics method to sort out and study the previous published papers.

Methods

We collected articles from the Web of Science Core Collection database in the field of snoRNA and cancer. Then, we used VOSviewer, Citespace, WPS and other software to visualize authors, Finally, we interpreted the data and analyzed the hotspots and frontiers of the research.

Results

The number of articles in this field was low in the early period, but exploded since 2008. According to the calculation of Prince's law, we believed that a stable cooperative group had been formed in this field. Chu, Liang and Montanaro, Lorenzo published the most papers, while Jiang, Feng were cited the most times. Three institutions published the most articles, namely Wuhan Univ, China Med Univ and Guangxi Med Univ. The journal with the most articles was Oncotarget. Through the analysis of countries/regions, it was found that the country with the most published articles was China. The analysis of keywords and burst words indicated that early studies mainly focused on the molecular mechanisms, but in recent years, it has gradually shifted to the direction of diagnosis, prognosis and therapy.

Conclusion

The research of snoRNA and cancer was a hot topic in recent years. Through analysis, we found that snoRNA was involved in the molecular mechanism of cancer development and can be used as a biomarker for clinical diagnosis and prognosis.
Three-Dimensional Femur Morphology Analysis for the Optimal Location of Subtrochanteric Osteotomy with an Implanted Wagner Cone Stem in Total Hip Arthroplasty for Crowe Type IV Developmental Dysplasia of the Hip
Authors: Tao Kun , Wang Shi-Cheng , Ma Xiao-Ying , Shao Long , Di Zheng-Lin , Huang Zhe-Yu 
Published: March 2023

Abstract
Background
This study aimed to accurately evaluate the matching of proximal and distal femoral segments and fitting of the femur–femoral stem in patients with Crowe type IV developmental dysplasia of the hip (DDH) who have undergone subtrochanteric osteotomy at different locations with an implanted Wagner cone stem to improve the rate of the bone union at the osteotomy site.
Methods
Three-dimensional femur morphology of 40 patients with Crowe type IV DDH was evaluated at each cross-section to determine the femoral cortical bone area. This study focused on five osteotomy lengths (2.5, 3, 3.5, 4, and 4.5 cm). The overlapped area between the proximal and distal cortical bone segments was defined as the contact area (S, mm2), and the contact area to distal cortical bone area ratio was defined as the coincidence rate (R). Three indicators were used to evaluate the matching and fitting of the osteotomy sites with the implanted Wagner cone stems: (i) higher S and R between the proximal and distal segments; (ii) the effective fixation length of the femoral stem at the distal segments being at least 1.5 cm; and (iii) osteotomy did not involve the isthmus.
Results
In all groups, S significantly decreased in the two proximal levels above the 0.5 cm level below the lesser trochanter (LT) compared with those below this level. In comparison, at osteotomy lengths from 2.5 to 4 cm, R significantly decreased in the three proximal levels. The optimal osteotomy levels ranged from 1.5 and 2.5 cm below the LT for an appropriately sized stem.
Conclusions
Subtrochanteric osteotomy at the optimal level not only ensures fitting of the femur–femoral stem but also meets the requirements of a higher S and R to ensure adequate reduction and immobilization at the osteotomy site, which may contribute to the bone union. Although the optimal osteotomy level varies with the size of the femoral stem and the length of the subtrochanteric osteotomy, the optimal osteotomy levels for an appropriately sized Wagner cone femoral stem implantation range from 1.5 to 2.5 cm below the LT.
Mixed neuroendocrine carcinoma consisting of small cell neuroendocrine carcinoma, metaplastic carcinoma, and invasive ductal carcinoma in the breast: A case report and review of the literature
Authors: Pan Zixin , Xiao Qinpei , Sun Kaixuan , Cui Jiayu , Zhang Baogang 
Published: March 2023

Abstract
Introduction: Neuroendocrine carcinoma accounts for less than 0.1% of all breast cancers and is a rare clinical cancer with neuroendocrine morphology, immunophenotype, and high-grade cytologic features. Case report: We report a case of a 54-year-old female patient with small cell neuroendocrine carcinoma of the right breast mixed with metaplastic carcinoma and invasive ductal carcinoma (non-specific type). Discussion: No cases of mixed occurrence of the three types of carcinoma in the breast have been reported in the literature. In this case, we made the diagnosis based on morphological features and immunohistochemistry, discussing the histogenetic mechanism and therapy prognosis. Conclusion: Due to the mixed occurrence of the three types of carcinoma, different morphological subtypes have different prognoses. Reporting the different components and their proportions becomes extremely important for clinical treatment and prognostic analysis in clinical work.
The influence of the lower order term and Hardy potential on existence and regularity results for nonlinear elliptic equations with degenerate coercivity
Authors: ACHHOUD F. , BOUAJAJA A. , MARAH A. , REDWANE H. 
Published: March 2023

Abstract
In this research we drive the existence and regularity results for solutions of some nonlinear degenerate Dirichlet problems containing two lower order terms, the first is a nonlinear convection term satisfying an optimal growth conditions and without any hypothesis of coercivity and the second is a zero order perturbation term, which called the hardy potential, that creates an obstruction to the existence of a solution. Not also that for right hand side, it is assumed that to be an Lm function with m ≥ 1.
MSC Classification: 35J60 , 35K05 , 35K67 , 35R09.
Dynamical Analysis of Two Cell Cycles with Delay Feedback Control
Authors: Ma Suqi 
Published: March 2023

Abstract
Double Hopf bifurcation of codimension 2 singularity in a type of two cells oscillator with interaction feedback connection is investigated. With the introduction of time delay which represents the communication time between cells, the stability switching phenomena is observed and double Hopf bifurcation occurs at the intersection point of Hopf lines. The geometrical scheme is applied in analyzing system stability underlying multiple time delays. The numerical simulation discovers that either the vicinity of bifurcating periodical solution on the margin of Hopf lines or the coexistence phenomena of five periodical solutions induced by stability switching phenomena. By applying the Schmidt dimensional reduction technique combined with the center manifold theory, the normal form of double Hopf point is calculated by parameter perturbation method and the near dynamics of double Hopf point is classified. The bifurcating periodical solutions and quasi-periodical solutions are observed which are in consistence with the numerical simulation results.
Fescue Toxicosis Update/Bovine Hysteria from Ammoniated Forages Update
Authors: Miksch Duane 
Published: March 2023

Fescue toxicity in cattle includes three distinct entities: fescue foot, fat necrosis and summer syndrome. Summer syndrome has a considerably greater economic impact than either of the other disorders. Summer syndrome denotes poor performance by cattle grazing tall fescue, especially notable during hot, humid weather. Signs include reduced feed consumption, decreased rate of gain and / or milk production, rough hair coat, increased respiratory rate, increased body temperature and general unthriftiness. Only summer syndrome has been positively associated with infection of tall fescue by the fungal endophyte, Acremonium coenophialum.Rare episodes of "crazy cattle" or "bovine bonkers" were reported from all over. Sometimes the syndrome appeared in cattle eating ammoniated feeds and in other instances it appeared in the calves nursing cows which were being fed ammoniated feeds. After several cases were investigated and compared, it was determined that the syndrome was related to what had occurred thirty years before when ammoniated molasses was fed to cattle. Ammoniated feedstuffs reported to have caused cattle bonkers include: forage sorghums, sudan hay, wheat hay, wheat straw, barley hay, oat hay, fescue hay , bromegrass hay , bermudagrass hay, orchardgrass hay, alfalfa hay and rice straw.
Adjusted Corrected Milk
Authors: Nordlund Ken 
Published: March 2023

Production medicine programs need a better yardstick. Production medicine programs need a basic unit of measurement. We need something precise, something as discrete as an inch, a fetal membrane slip, or a beta-hemolytic zone.
It isn't that we don't have numbers. No, our OHi reports have plenty of numbers. We have rolling herd averages, standardized mature equivalents, and income over feed costs. We have heat detection indexes. That isn't the problem. The problem is that some of these numbers seem to lack immediacy, directness, and sometimes accuracy.
My purpose here is not to belittle. Rather, I want to comment on using average milk production per day as a monitor of response to production medicine programs.
Practical Water Evaluation for Dairy Cattle
Authors: Rodenburg Jack 
Published: March 2023

Water is an essential component of the ration of all types of livestock. While most dairy farms have an ample supply of good quality water, bacterial contamination, high levels of dissolved minerals, or physical factors which restrict intake can cause health problems and reduce milk production.
Water consumption of cattle varies with body size, level of milk production, ambient temperature and intake of dry matter, protein salt and other minerals.
Impacts of Early Postpartum Metabolism on Follicular Development and Fertility
Authors: Britt Jack H. 
Published: March 2023

High producing dairy cows often experience low rates of conception during the target breeding period of 60 to 120 d postpartum (Faust et al., 1988; Harrison et al., 1990). Low fertility is costly for dairy producers because of extra expenditures for semen and insemination and because of reduced income from excessive days open (Britt, 1985). Cows that fail to conceive to AI between 60 and 120 d postpartum often are bred to clean-up bulls of unknown genetic merit. This not only affects long-range potential income for producers, but it reduces the number of records available for AI progeny testing programs.
Review of experimental data and careful study of published papers reveal that not all high producing healthy cows experience low fertility during the breeding period (Butler and Smith, 1989; Fonseca et al.,1983; Helmer and Britt, 1986; Staples et al.,1990). On a within-herd basis, the association between level of production and fertility is often weak (Fonseca et al., 1983). This leads one to suspect that factors other than high production per se are responsible for low fertility. It is with this concept in mind that we have begun to examine various biological pathways that might account for differences in fertility in otherwise healthy high-producing cows.
This paper will focus on one potential pathway namely the latent effect of early postpartum metabolism on quality of follicles destined to ovulate during the breeding period. Such follicles influence fertility in two ways: 1) through the quality grade or viability of the ovulated oocytes, and 2) through the amount of progesterone secreted by corpora lutea (CL) formed from these follicles (Fonseca et al., 1983). This paper examines the possibility that quality of a follicle is dependent on the conditions under which it begins its initial development many weeks prior to ovulation.
Cattle and the Petroleum Industry
Authors: Waldner Cheryl 
Published: March 2023

Veterinarians are occasionally called upon to investigate concerns from cattle producers who feel they have suffered economic losses resulting from the effects of industrial activity on the health and productivity of their livestock operation. The following is an introduction to some of the problems that can occasionally result from the close proximity of cattle to petrochemical activities. Some strategies for investigating these types of problems are also suggested. Peer-reviewed experimental or observational field studies of the effects of the petroleum industry on livestock are very limited. The available literature consists of scattered case reports, reviews of these case reports, a few small experimental dosing studies in cattle, experimental results extrapolated from other species, and observational reports from the "gray literature" of conference proceedings and environmental accidents or complaint investigations.
This paper is intended as a brief introduction for the practicing veterinarian called to investigate petroleum related complaints. It is not intended to be an exhaustive review of the available material. A more detailed presentation of the potential hazards to livestock from the oil and gas industry has recently been released by the Alberta Cattle Commission.1
Prevention and Treatment of Down Cows
Authors: Cox V. S. , Farmsworth R. J. 
Published: March 2023

The point where a down cow is no longer considered to be down temporarily but has become a "real" downer is at best arbitrary. Therefore, the line between prevention and treatment is also arbitrary. This terminology matter is only an academic issue, but it is useful to point out a general principle. That is: many of the measures used to prevent downers are the same ones used to manage downers in order to prevent them from getting worse and thereby provide time for healing. The major management tools1 for both prevention and treatment are:1. Providing a good non-slip surface to make it possible for cows to stand unassisted whenever possible.2. Providing a means to minimize compression damage due to recumbency. The 2 main tools here are comfortable and clean bedding and a variety of lifting or support methods.
Prevention and treatment of the primary causes of recumbency per se are beyond the scope of this paper and will be covered in detail by other participants. Much can be done to prevent metabolic problems by good dry cow dietary management, but the more mundane matter of providing a safe environment for calving is often overlooked.
Development and optimization of the dye removal process byTrichoderma reeseiusing starch effluent as a growth supplement
Authors: Kalia Shweta , Samuchiwal Saurabh , Dhaka Vidushi , Malik Anushree 
Published: March 2023

AbstractThe textile industry generates enormous starch effluent from the desizing process that can be utilized as a nutrient source for fungal growth and simultaneous dye decolorization. In the present study, Trichoderma reesei was used as a potential fungal isolate for the decolorization of reactive dyes using a minimal salt media for growth. The dye removal of Reactive blue 13, Reactive red 198, Reactive yellow 176, and Reactive black 5 were 95.35, 88.17, 86.01, and 94.84 mg L−1, respectively, by fungal biomass at 100 mg L−1 of initial dye concentration in 48 h was achieved. T. reesei showed decolorization of dyes at initial concentrations upto 500 mg L−1 with high dye uptake capacity. The glucose (5 g L−1) and yeast extracts (2.5 g L−1) were optimal for maximum dye decolorization. The utilization of starch effluent as an alternative nutrient source supplemented with 3.5 g L−1 glucose as growth media by T. reesei showed &gt;85% of decolorization of Reactive blue 13 (100–200 mg L−1). Thus, starch effluent could be partially supplemented with glucose to support fungal growth and dye decolorization, eliminating the requirement of minimal salts for dye decolorization that follows a sustainable approach.
A data quality assessment framework for drinking water distribution system water quality time series datasets
Authors: Gleeson Killian , Husband Stewart , Gaffney John , Boxall Joby 
Published: March 2023

Abstract
The derivation of information from monitoring drinking water quality at high spatiotemporal resolution as it passes through complex, ageing distribution systems is limited by the variable data quality from the sensitive scientific instruments necessary. A framework is developed to overcome this. Application to three extensive real-world datasets, consisting of 92 multi-parameter water quality time series of data taken from different hardware configurations, shows how the algorithms can provide quality-assured data and actionable insight. Focussing on turbidity and chlorine, the framework consists of three steps to bridge the gap between data and information; firstly, an automated rule-based data quality assessment is developed and applied to each water quality sensor, then, cross-correlation is used to determine spatiotemporal relationships and finally, spatiotemporal information enables multi-sensor data quality validation. The framework provides a method to achieve automated data quality assurance, applicable to both historic and online datasets, such that insight and actionable insight can be gained to help ensure the supply of safe, clean drinking water to protect public health.
GTAR: a new ensemble evolutionary autoregressive approach to model dissolved organic carbon
Authors: Danandeh Mehr Ali , Marttila Hannu , Haghighi Ali Torabi , Croghan Danny , Fathollahzadeh Attar Nasrin 
Published: March 2023

AbstractThis article explores the forecasting capabilities of three classic linear and nonlinear autoregressive modeling techniques and proposes a new ensemble evolutionary time series approach to model and forecast daily dynamics in stream dissolved organic carbon (DOC). The model used data from the Oulankajoki River basin, a boreal catchment in Northern Finland. The models that were evolved used both accuracy and parsimony measures including autoregressive (AR), vector autoregressive (VAR), and self-exciting threshold autoregressive (SETAR). The new method, called genetic-based SETAR (GTAR), evolved through the integration of state-of-the-art genetic programming with SETAR. To develop the models, high-resolution DOC concentration and daily streamflow (as the external input for VAR) were measured at the same gauging station throughout the ice free season. The results showed that all the models characterize the DOC dynamics with an acceptable 1-day-ahead forecasting accuracy. Use of the streamflow time series as an exogenous variable did not increase the predictive accuracy of AR models. Moreover, the hybrid GTAR provided the best accuracy for the holdout testing data and proved to be a suitable approach for predicting DOC in boreal conditions.