bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulatory Effects of Noradrenergic and Serotonergic Signaling Pathway on Neurovascular Coupling
Authors: Tran Cam Ha , Renden Robert , Institoris Adam , Sharma Kushal 
Published: July 2023

Abstract
Dynamic changes in astrocyte Ca2+ are recognized as contributors to functional hyperemia, a critical response to increased neuronal activity mediated by a process known as neurovascular coupling (NVC). Although the critical role of glutamatergic signaling in this process has been extensively investigated, the impact of behavioral state, and the release of behavior-associated neurotransmitters, such as norepinephrine and serotonin, on astrocyte Ca2+ dynamics and functional hyperemia have received less attention. We used two-photon imaging of the barrel cortex in awake mice to examine the role of noradrenergic and serotonergic projections in NVC. We found that both neurotransmitters facilitated sensory-induced increases in astrocyte Ca2+. Interestingly, while ablation of serotonergic neurons reduced sensory-induced functional hyperemia, ablation of noradrenergic neurons caused both attenuation and potentiation of functional hyperemia. Our study demonstrates that norepinephrine and serotonin are involved in modulating sensory-induced astrocyte Ca2+ elevations and identifies their differential effects in regulating functional hyperemia.
Expert System Based Diabetes Diagnoses Using Ensemble Model
Authors: ROY PAPPU CHANDRA , MISHRA SUDHIR KUMAR 
Published: July 2023

Abstract
The title “Expert Systems” was given by John McCarthy, in which he entitled his study as “Applied Science and Technology” of making quick witted devices”. The development of ‘thinking’ computer systems popularly known as “Expert Systems” furthermore; also known as “Synthetic Intelligence” which explains the idea of learning these algorithms so that they can act intelligently. The mindset of software programs is basically to execute their activities intelligently like humans. The designs that allow software programs to work in such a way which frames its society as the ability to act intelligently known as Expert systems. The ability of these systems in order to use relevant connection between database which can be used in primary level screening for various disease, proper medication as well as estimating various results. In today’s growth following approach is being used in all useful domains which are beneficial for the society so that complex issues could be solved on time. This domain was being setup on the increasing demand the central attribute of human – mind can be imitated via these Expert systems.The work executed in this domain depicts how these expert systems could work intelligently provided if the data fed to this system is precisely accurate and tested by cross validation. To carry out this research total fourteen classifiers are being studied out of which we find four algorithms more suitable for this research namely Artificial Neural Network, K-Nearest Neighbor, Support vector machine, Naïve bayes. On top of it, to make our results more accurate and efficient, ensemble technique is used which predicts the output by taking the majority number of votes from the results predicted by these algorithms; in order to make this tool more efficient and accurate. The software tools which are being used are to execute this research are matrix laboratory and weka 3.6.13. After detailing of medical history, we prepared a rich dataset of around 400 people which is taken in the form of questionnaire from different sections of the society on the basis of ten physiological parameters. This enriched data has been tested and validated in terms of accuracy and prediction of correct data. This trained dataset is fed to graphical user interface and is tested so that it can predict correct output on the given input data provided to it.The values which are provided to the interface are five numeric values and rest are nominal values. The fig which illustrates the working of this tool is shown in Fig. 3. The foremost aim of this proposed work is to build an intelligent tool which is capable of predicting accurate results and provide correct data so that it could prove helpful in medical domain and can be used for initial screening of patients at an earlier stage so that proper treatment can be followed by them.Talking about the privacy of these algorithms out of all algorithms ANN outperformed with accuracy of 97.5% and our proposed ensembling technique assured the accuracy of 98%.
Performance Analysis of Rare-earth Doped Oxide Thin-Film Transistors Using Neural Network Method
Authors: Peng Zengyi , Huang Xianglan , Shen Yuanyi , Wu Weijing , Li Min , Xu Miao , Wang Lei , Gu Zhenghui , Yu Zhuliang , Peng Junbiao 
Published: July 2023

Abstract

The work analyzes the key impact factors on the performances of rare-earth element doped oxide thin film transistors (TFTs), which are potentially used for high performance displays, by comparatively using a Bayesian Neural Network (BNN) method and Artificial Neural Network (ANN) method based on published and self-experimental data which was exhaustively collected. Both BNN and ANN methods can effectively identify the primary impact factors among rare-earth element type, doping concentration, thin film thickness, channel length and width, which are key factors to determine the TFTs performances. Comparisons between the ANN and BNN methods, the BNN approach offers more reliable and robust predictions on the dataset. Accordingly, the efficient neural network models tailored to the data features were accurately established. A key outcome from the BNN models is the relative importance ranking of the influence factors and relationship between the carrier mobility and element type, concentration as well. To the TFT mobility, rare-earth element concentration is the most critical factor, suggesting lower concentration exhibited higher mobility, followed by the rare-earth element type. To the sub-threshold swing performance of TFTs, the rare-earth element type is the most significant influence factor, suggesting higher valence rare-earth is superior to lower valence one, followed by the element concentration. The results are basically consistent with experimental tendency. These insights could effectively guide the design of oxide semiconductor materials and TFT device structure, to achieve high-performance (high mobility and high stability) oxide TFT devices for displays.
“Uptake of breast cancer screening services among undergraduate female students in the oldest University of Tanzania: a cross-sectional study”
Authors: Mally Mary , Tesha Novatus , Anaeli Amani 
Published: July 2023

Abstract

Background
Worldwide breast cancer is the leading cause of cancer-related death among women. Breast cancer mortality can be reduced by early detection and prevention. Despite the existence of breast cancer screening methods, uptake of breast cancer screening is still very low partly due to a lack of awareness of the risk factors for breast cancer and poor knowledge of the screening services. This study was set to assess uptake of breast cancer screening service among undergraduate female students in Dar es Salaam.
Methods
This was an analytical cross-sectional study which conducted among 434 undergraduate female students using self-administered questionnaires in July 2022. Data were analyzed using Stata Version 15 and presented using descriptive and inferential statistics.
Results
The results of this study show that those who have ever been screened for breast cancer were 37 (9.23%), and 40% of the participants have heard about breast cancer screening methods. The most common screening method practiced by study participants was breast self-examination (48.65%). The knowledge of the participants regarding risk factors for breast cancer was generally low; only 40% of the participants had good knowledge of the breast cancer risk factors.
Conclusion
The uptake of breast cancer screening service in the studied area was generally low, as majority of the participants were not aware of screening methods for early detection of breast cancer.
PIT tagging does not measurably reduce reproductive success in sensitive burrow-nesting seabirds
Authors: Marcouillier Léo , Miranda Eliane , Whelan Shannon , Fifield Dave , Hatch Scott , Shoji Akiko , Nakajima Chinatsu , Elliott Kyle 
Published: July 2023

Abstract
Investigator disturbance while monitoring seabirds often results in lower survival rates and breeding success, leaving lasting negative impacts on the population and biased observations. Puffins, in particular, are more sensitive to investigator disturbance than many other seabirds, and researchers must seek to decrease their disturbance and time spent at puffin colonies. Radio-Frequency Identification (RFID) via Passive Integrated Transponder (PIT) tags is an inexpensive and reliable way to identify individuals when coupled with automated RFID detectors, potentially avoiding the need for recapture for nocturnal seabirds. PIT tags either can be implanted subcutaneously or attached externally to leg bands, but it is unclear which method causes lower disturbance. To examine the impact of PIT tagging on rhinoceros auklets (Cerorhinca monocerata; a member of the puffin clade) nesting in artificial burrows on Middleton Island, Alaska, during the 2022 breeding season, we monitored burrow entrances with automated recording RFID readers to collect presence and nest attendance data. PIT tagged and control birds had similar breeding success and chick growth rates. Birds tagged externally were detected less often than birds marked with a subcutaneous implant. We conclude that PIT tagging on the rhinoceros auklet is a relatively non-invasive method for seabird monitoring, and that subcutaneous implants doesn't cause more disturbance than external attachment.
Relationship between serum soluble suppression of tumorigenicity (ST) 2 and global longitudinal strain in early onset preeclampsia
Authors: Prameswari Hawani , Effendi Cut Azlina , Khalid Achmad , Irianti Setyorini , Fatati Ita , Akbar Mohammad 
Published: July 2023

Abstract

Background: Early onset preeclampsia, defined as preeclampsia that occurs before 34th weeks, has a higher cardiovascular events due to higher cytokine concentrations. Hemodynamic changes in preeclampsia can trigger cardiac remodeling as indicated by increase of soluble-ST2 (sST2). Global longitudinal strain were able to detect systolic dysfunction better than the ejection fraction. This study aims to evaluate the correlation between serum levels of sST2 towards GLS in patients with early-onset preeclampsia.
Methods: This is a cross-sectional observational study with correlation analysis. Subjects were patients with severe preeclampsia with gestational age before 34 weeks at Dr. Hasan Sadikin Bandung and Bandung Kiwari Regional General Hospital from June to August 2022. Examination of sST2 was carried out through blood samples using the ELISA method. sST2 was measured using Presage ST2 Assay reagent. GLS examination was carried out using speckle tracking technique with EchoPAC. Correlation analysis was conducted using the Pearson test if normally distributed, otherwise Spearman's correlation was conducted. Correlation analysis was followed by linear regression.
Results: A total of 30 patients met the inclusion criteria. The mean age was 30.83 ± 7.09, with 17 (56.7%) multiparous patients. The median sST2 was 145.75 ng/mL, and the median GLS was -17.4%. Spearman correlation analysis showed that there was a significant negative correlation with moderate strength between sST2 and GLS (r=0.583; p<0.002). Linear regression showed that every 1 ng/ml increase in sST2 would give a decrease in GLS of 0.014%.
Conclusion: There is a significant correlation between sST2 and GLS in patients with early onset severe preeclampsia.
Presence of Coronary Artery Disease in Adults with Newly Detected Diabetes Mellitus
Authors: Lai Cheng-Chien , Chang Betty Chia-Chen , Hwang Lee-Ching 
Published: July 2023

Abstract

Purpose
We aimed to analyze the presence and extent of coronary artery disease in patients with newly detected diabetes mellitus.
Methods
Clinical health examinations of asymptomatic community-dwelling adults between 2008 and 2018 at a medical center in Taiwan were reviewed. Coronary computed tomography angiography was performed in 444 participants, of which 338, 54, and 52 were categorized as ‘without diabetes mellitus’, ‘newly detected diabetes mellitus’, and ‘known diabetes mellitus’, respectively.
Results
Prevalence of significant coronary artery disease (≥ 50% stenosis) was higher in participants with newly detected diabetes mellitus than participants without diabetes mellitus (40.7% vs 20.1%, p < 0.0001). Among those with coronary artery stenosis, the number of coronary vessels with significant obstruction (0.72 vs 0.42, p = 0.0147) was also higher in participants with newly detected diabetes mellitus. Using multiple logistic regression analysis, new detection of diabetes mellitus was identified as an independent risk factor for significant coronary artery disease (odds ratio: 2.153, 95% confidence interval: 1.112–4.166).
Conclusion
Asymptomatic patients with newly detected diabetes mellitus had higher prevalence and greater extent of coronary artery disease than those without diabetes mellitus. More attention should thus be paid to the assessment of coronary artery disease in patients with newly detected diabetes mellitus.
Solution synthesis and enhanced photocatalytic activity of layered ZnO and MoS 2 hybrid nanostructure
Authors: Liu Lili , Chen Ping , zhang xin , Kovarik Libor , De Yoreo James , Liu Jun , Sushko Maria L. 
Published: July 2023

Abstract
Numerous inorganic materials have been identified as potential candidates for high-performance photocatalysts. However, their solar-to-energy conversion efficiencies still fail to meet commercial requirements. The main hurdle is the rapid recombination of photoexcited electrons and holes in single-phase materials. A viable predicted approach to suppress charge recombination is coupling two materials to form a two-dimensional (2D) heterostructure that physically separates photoinduced electrons and holes in different layers. In this work, the heterostructure-based paradigm was tested and a scalable solution synthesis of epitaxial ZnO-MoS2 heterostructure was developed. A 2D ZnO-MoS2 heterostructure was synthesized under hydrothermal conditions by stabilizing intermediate Zn-hydroxide states on a functionalized MoS2 surface. Detailed characterization showed the formation of multilayer heterostructure with MoS2 flakes intercalated between large size ZnO plates. The performance of this heterostructure was evaluated using photocatalytic degradation of rhodamine B. A degradation efficiency of 70% was measured within 90 minutes of visible-light irradiation, almost doubling the efficiency of the corresponding single-phase materials or their physical mixtures.
The effect of δ (delta)-catenin on small-world brain network properties in breast cancer patients before chemotherapy
Authors: Xue Mingtuan , Du Wei , Cao Jiajun , Jiang Yuhan , Song Duan , Yu Dan , Zhang Junyi , Guo Junjie , Xie Xuejun , Xie Lizhi , Miao Yanwei 
Published: July 2023

Abstract

Our study is to investigate the effect of δ-catenin on the alterations in small-world brain network before chemotherapy in breast cancer patients by rs-fMRI, based on the hypothesis that different δ-catenin expressions have independent brain imaging characteristics. A total of 105 cases of pathologically confirmed breast cancer were collected and divided into high δ-catenin expression (DH, 52 cases) and low expression (DL, 53 cases) groups. Also, 36 healthy women matched for age were enrolled as a healthy control group (HC). The results show differences in several network topology attributes among the three groups. Furthermore, in addition to differences in nodal efficiency, betweenness and degree centrality metrics between the patient group and HC in multiple brain regions, there were also alterations between the DL and DH groups in brain regions such as the supramarginal and inferior frontal gyrus, which supports our hypothesis. Neuropsychological scores also showed that the DL group had significantly shorter short and long-term memory times than the DH group. The study concluded that different states of δ-catenin had significantly different effects on the attributes of the breast cancer patients' brain network and had characteristic impacts on some brain regions. They could also be involved in executive function-related cognitive functions and changes in regulating emotions.
Solar Pre-drying Study of Sorption Isotherms of Saharan Fish
Authors: Larbi Ahmed Amine , Mediani Ahmed , Djaber Abdelkarim , Cherif Tigani , Naima Ouled Amar , Zahra Klimani 
Published: July 2023

AbstractThe objective of this study is to determine the desorption isotherms of Saharan fish in order to predict the ideal conditions for solar drying and storage. The experiments were conducted at different temperatures using the gravimetric-static method, with a defined range of water activity. The results reveal that the desorption isotherms of Saharan fish behave in accordance with type II, as per the BET classification. Specifically, the equilibrium moisture content decreases with increasing temperature for each level of water activity, and a clear hysteresis effect is observed. Four mathematical models were applied to fit the experimental data, and it was found that the GAB model accurately represents the desorption isotherms of Saharan fish. Important parameters such as the isosteric heat of sorption and the shelf life of the product were deduced from these isotherms. The physicochemical analysis of our Saharan fish provides detailed information on their composition and properties, while the microbiological analysis of fresh and dried fish reveals the presence of various microorganisms, with varying microbial load. These results offer vital information for the industry, thereby contributing to the improvement of quality management, shelf life, and production of Saharan fish products.
Manual-assisted pressure reduction versus pressure reduction alone for intussusception in pediatric patients: a case-control study
Authors: Gou Zehui , Xie Xiaolong , Zheng Qianwen , Liu Juxian 
Published: July 2023

Abstract
Purpose: The aim of this present study was to compare the effectiveness of combined manual-assisted reduction and pneumatic/hydrostatic reduction versus pneumatic/hydrostatic reduction alone in treating pediatric patients with intussusception.
Methods: Children suffered from intussusception who were treated by pneumatic/hydrostatic reduction with or without manual assistance between January 2019 and January 2021 were retrospectively analyzed. According to the method of reduction, the patients were grouped as MPH group (combination of pneumatic/hydrostatic reduction and manual assistance) and PH group (the pneumatic/hydrostatic reduction alone). The data collected included the demographic information, clinical symptoms, abdominal signs, investigations, success rate of reduction and details of failure cases.
Results: A total of 751 children were finally included in the analysis, including 380 patients in the PH group and 371 patients in the MPH group. There were no significant differences in baseline characteristics between the PH group and the MPH group. The time of radiation exposure time and reduction in PH group (155.53±30.34 s, 267.71±40.17 s, respectively) were significantly higher than those in MPH group (112.67±30.29 s, 222.69±53.18 s, respectively) (p <0.001). While the success rate of reduction in MPH group (363 cases, 97.84%) was significantly higher than that in PH group (361 cases, 95.00%) (p =0.036). There were no statistical differences in perforation rate and recurrence rate between the two groups.
Conclusion: Pneumatic/hydrostatic reduction combined manual assistance can increase the success rate of reduction, decrease the time of radiation exposure and and will not increase the incidence of complications, which is worth promoting in clinical practice.
Percutaneous Nephrolithotomy in Patients with Incidental Encountered Purulent Urine at Initial Puncture
Authors: Sipal Timucin ,   2.	Ibrahim Senocak,   3.	Mirac Ataman, Yuvanc Ercan , Yilmaz Erdal 
Published: July 2023

Abstract

Objective:
We are reporting the 39 patients’ outcomes who underwent percutaneous nephrolithotomy and purulent urine is encountered at the initial steps of surgery.
Method:
Of 873 patients who underwent PCNL, 48 had purulent fluid during the initial puncture. After excluding those at risk for infection, we studied 39 patients' preoperative and postoperative variables - including postoperative day (POD) 1,3,5 fevers. In group 1, 21 patients had a nephrostomy tube placed, and PCNL was postponed. In group 2, 18 patients had successful stone removal in the first session.
Results:
All surgeries were successful, with no septic events during follow-up. No significant differences in preoperative variables were found. 14% and 22% of patients in groups 1 and 2 had infected fluid (p= 0.470). Four patients in group 1 (19 %) and seven patients in group 2 (38.9 %) had a high fever (≥ 38 C) on POD1 (p =0.171), and 1 (5%) in group 1 and 3 (17%) in group 2 had high fever on POD 3 (p= 0.22). No patients remained with high fever on POD5. Mild sepsis was diagnosed in 9.5 % of group 1 and 16 % of group 2 (p= 0,820), and hospitalization time differed significantly (p< 0.001). Stone size and operation time were correlated with postoperative fever, and prolonged hospital stays were correlated with positive blood cultures and postponed procedures.
Conclusion:
PCNL with proper technique and antibiotics can lead to quicker recovery and reduced hospitalization in selected patients with pus in their urine during surgery