bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling
Authors: Sun Jialing , Yang Xuemei , Sun Haitao , Huang Shaohui , An Haiyan , Xu Wei , Chen Weicong , Zhao Wenting , He Chunyu , Zhong Xiaodan , Li Tong , Liu Yang , Wen Bin , Du Qingfeng , He Songqi 
Published: May 2023

AbstractHepatocellular carcinoma (HCC) is a common malignancy affecting many people worldwide. Baicalin is a flavonoid extracted from the dried root of Scutellaria baicalensis Georgi. It can effectively inhibit the occurrence and development of HCC. Nonetheless, the mechanism through which Baicalin inhibits HCC growth and metastasis remain unknown. This work discovered that Baicalin inhibited HCC cell proliferation, invasion, metastasis while inducing cell cycle arrest at the G0/G1 phase and apoptosis. In vivo HCC xenograft results indicated that Baicalin inhibited HCC growth. Western blotting analysis indicated that Baicalin suppressed the expressions of ROCK1, p‐GSK‐3β, and β‐catenin, whereas it up‐regulated the expressions of GSK‐3β and p‐β‐catenin. Baicalin also reduced the expressions of Bcl‐2, C‐myc, Cyclin D1, MMP‐9, and VEGFA, while increasing the expression of Bax. Molecular docking revealed that Baicalin docked in the binding site of the ROCK1 agonist, with a binding energy of −9 kcal/mol between the two. In addition, lentivirus‐mediated suppression of ROCK1 expression improved the inhibitory effect of Baicalin on the proliferation, invasion, and metastasis of HCC and the expression of proteins associated with ROCK1/GSK‐3β/β‐catenin signaling pathway. Moreover, restoring ROCK1 expression decreased the anti‐HCC efficacy of Baicalin. These findings suggest that Baicalin may decrease HCC proliferation and metastasis by suppressing ROCK1/GSK‐3β/β‐catenin signaling.
Fabrication of antimicrobial colorimetric pad for meat packaging based on polyvinyl alcohol aerogel with the incorporation of anthocyanins and silver nanoparticles
Authors: He Yue , Chen Shiguang , Xu Dan , Ren Dan , Wu Xiyu 
Published: May 2023

AbstractA novel colorimetric pad with porous structure, good antimicrobial activity, and pH‐sensitivity has been developed based on polyvinyl alcohol (PVA), paper fibre, silver nanoparticles (AgNPs) and purple sweet potato anthocyanins (PSPA), aiming for the preservation and freshness indication of fresh meat. The effects of AgNPs content on the structure, physical properties and colour‐changing behaviour in response to pH of the pad were investigated. The results showed that AgNPs physically interacted with polymer matrix and improved the uniformity of the internal pore structure of the pad. The antibacterial capability, DPPH radical scavenging activity and surface hydrophobicity of the pad increased significantly with increasing AgNPs content. However, the pH sensitivity of the pad was maintained with the addition of AgNPs, and the colour change of pad A‐9 with pH was the most distinguishable when AgNPs content was the highest. When pad A‐6 was used in the packaging of minced pork, compared to pad A‐0 without the addition of AgNPs, it showed more significant effects in inhibiting microbial growth, reducing the production of volatile nitrogen compounds, improving the sensory quality of meat (p < 0.05), thereby extending the shelf life from 72 h to 120 h at 4°C. Moreover, A‐6 displayed a visible colour change in response to the spoilage of minced pork in real time. Therefore, the developed pad with dual functions had great potential to be applied as a novel active and intelligent packaging for fresh meat, which would contribute towards reducing food waste and ensuring food safety.
The influence of clean food labels on consumers' perception
Authors: Sá Amanda Gomes Almeida , Carmo Lucas Moreira , Valencia Germán Ayala 
Published: May 2023

AbstractFood marketing uses packaging to attract consumers. Clean labels (CLs) have been proposed as a recent alternative to attract consumers and increase purchasing intention; however, the impact of CL on consumers' perception has not been extensively studied. In this way, the current research aimed to understand the effect of CL used in frequent food consumed by the Brazilian population (cereal bars, sandwich cookies, yogurt, loaf bread, tomato paste and ketchup) and their impact on consumers' perception. A study with 392 volunteers was carried out, and the data were obtained through an online form and analysed using an electronic spreadsheet. Each volunteer compared similar food inside packaging with conventional labels or CL, considering the same price and expiration date. Data derived from consumers' perceptions were analysed using the word association (WA) methodology. Results from volunteers showed that people verify the presence of natural ingredients in food products and prefer processed products with CL. Furthermore, several variables used to develop CL such as product quality, nutritional value and ingredients were mentioned by the volunteers as parameters influencing purchasing intention. Finally, results from WA confirmed the preference of volunteers by food packages with CL; in this way, food products with CL were correlated with sensory and nutritional aspects. This study confirms the importance of CL in processed food packaging and its importance to induce positive feelings in consumers.
A new approach to represent model uncertainty in the forecasting of tropical cyclones: The orthogonal nonlinear forcing singular vectors
Authors: Zhang Yichi , Duan Wansuo , Vannitsem Stéphane , Zhang Han 
Published: May 2023

AbstractTropical cyclone (TC) track forecasting has been considerably improved in recent decades, while TC intensity forecasting remain challenging. In this study, orthogonal nonlinear forcing singular vectors (O‐NFSVs) for emulating the impact of model uncertainties are used to conduct TC ensemble forecasting experiments with the Weather Research and Forecasting (WRF) model, with a focus on improving TC intensity forecasting skill. The O‐NFSVs approach is compared with the traditional stochastic kinetic‐energy backscatter (SKEB) and stochastically perturbed parametrization tendency (SPPT) schemes. The results demonstrate that the O‐NFSVs ensembles generally provide a better representation of the model uncertainties affecting TC intensification, with much better deterministic and probabilistic skills. These results also extend to the ability to forecast TC track, although the perturbations have not been optimized for that specific purpose. The O‐NFSVs are therefore appropriate perturbation structures for describing the uncertainties of the TC intensity and track forecasting and are also favourable for recognizing the rapid intensification process.
Demonstration of localization for construction vehicles using 3D LiDARs installed in the field
Authors: Inagawa Masahiro , Kawabe Tomohito , Takei Toshinobu 
Published: May 2023

AbstractLocalization methods for autonomous construction vehicles include real‐time kinematic positioning through a global navigation satellite system (GNSS) and a scan matching with a light detection and ranging (LiDAR) attached to mobility. However, these conventional methods have low estimation accuracy when the vehicle's surroundings have few features and the vehicle is in the no‐GNSS area. For the estimation in such areas, this paper proposes a localization method that can estimate by matching a 3D model of a construction vehicle with a point cloud obtained from 3D LiDARs installed in a work area. To realize the high‐accuracy and high‐speed processing of the localization, we propose remodeling using the predictive motion model (RM) algorithm to modify the 3D model in the registration process. In the experimental results on rough terrain, we confirmed that our method can estimate a vehicle's position and yaw angle with accuracies of 0.121 m and 0.016 rad, respectively. In addition, compared with the case without the RM algorithm, the construction vehicle's position and yaw angle accuracies improved up to 5 and 12 times, respectively.
Correlating the Dipolar Interactions Induced Magneto‐Viscoelasticity and Thermal Conductivity Enhancements in Nanomagnetic Fluids
Authors: Singh Rahul , Pathak Saurabh , Jain Komal , Noorjahan  , Kim Sang‐Koog 
Published: May 2023

AbstractThe effective thermal management of electronic system holds the key to maximize their performance. The recent miniaturization trends require a cooling system with high heat flux capacity, localized cooling, and active control. Nanomagnetic fluids (NMFs) based cooling systems have the ability to meet the current demand of the cooling system for the miniaturized electronic system. However, the thermal characteristics of NMFs have a long way to go before the internal mechanisms are well understood. This review mainly focuses on the three aspects to establish a correlation between the thermal and rheological properties of the NMFs. First, the background, stability, and factors affecting the properties of the NMFs are discussed. Second, the ferrohydrodynamic equations are introduced for the NMFs to explain the rheological behavior and relaxation mechanism. Finally, different theoretical and experimental models are summarized that explain the thermal characteristics of the NMFs. Thermal characteristics of the NMFs are significantly affected by the morphology and composition of the magnetic nanoparticles (MNPs) in NMFs as well as the type of carrier liquids and surface functionalization that also influences the rheological properties. Thus, understanding the correlation between the thermal characteristics of the NMFs and rheological properties helps develop cooling systems with improved performance.
The Interaction in Electrolyte Additives Accelerates Ion Transport to Achieve High‐Energy Non‐Aqueous Lithium Metal Batteries
Authors: Li Zhaojie , Zheng Xueying , Ye Siyang , Ou Chuan , Xie Yong , Li Zhenbang , Tian Fei , Lei Danni , Wang Chengxin 
Published: May 2023

AbstractElectrolyte engineering is a feasible strategy to realize high energy density lithium metal batteries. However, stabilizing both lithium metal anodes and nickel‐rich layered cathodes is extremely challenging. To break through this bottleneck, a dual‐additives electrolyte containing fluoroethylene carbonate (10 vol.%) and 1‐methoxy‐2‐propylamine (1 vol.%) in conventional LiPF6‐containing carbonate‐based electrolyte is reported. The two additives can polymerize and thus generate dense and uniform LiF and Li3N‐containing interphases on both electrodes’ surfaces. Such robust ionic conductive interphases not only prevent lithium dendrite formation in lithium metal anode but also suppress stress‐corrosion cracking and phase transformation in nickel‐rich layered cathode. The advanced electrolyte enables Li||LiNi0.8Co0.1Mn0.1O2 stably cycle for 80 cycles at 60 mA g−1 with a specific discharge capacity retention of 91.2% under harsh conditions.
Uniform Gold Nanostructure Formation via Weakly Adsorbed Gold Films and Thermal Annealing for Reliable Localized Surface Plasmon Resonance‐Based Detection of DNase‐I
Authors: Park Joon‐Ha , Wang Chi‐Pin James , Lee Hye‐Jin , Hong Kyung Soo , Ahn Jung Hong , Cho Yeon‐Woo , Lee Jeong‐Hyeon , Seo Hee Seung , Park Wooram , Kim Se‐Na , Park Chun Gwon , Lee Wonhwa , Kim Tae‐Hyung 
Published: May 2023

AbstractDeoxyribonuclease‐I (DNase‐I), a representative endonuclease, is an important biomarker for the diagnosis of infectious diseases and cancer progression. However, enzymatic activity decreases rapidly ex vivo, which highlights the need for precise on‐site detection of DNase‐I. Here, a localized surface plasmon resonance (LSPR) biosensor that enables the simple and rapid detection of DNase‐I is reported. Moreover, a novel technique named electrochemical deposition and mild thermal annealing (EDMIT) is applied to overcome signal variations. By taking advantage of the low adhesion of gold clusters on indium tin oxide substrates, both the uniformity and sphericity of gold nanoparticles are increased under mild thermal annealing conditions via coalescence and Ostwald ripening. This ultimately results in an approximately 15‐fold decrease in LSPR signal variations. The linear range of the fabricated sensor is 20–1000 ng mL−1 with a limit of detection (LOD) of 127.25 pg mL−1, as demonstrated by spectral absorbance analyses. The fabricated LSPR sensor stably measured DNase‐I concentrations from samples collected from both an inflammatory bowel disease (IBD) mouse model, as well as human patients with severe COVID‐19 symptoms. Therefore, the proposed LSPR sensor fabricated via the EDMIT method can be used for early diagnosis of other infectious diseases.
Aurozyme: A Revolutionary Nanozyme in Colitis, Switching Peroxidase‐Like to Catalase‐Like Activity
Authors: Kim Hyung Shik , Lee Sieun , Lee Dong Yun 
Published: May 2023

AbstractA therapeutic strategy that could address colitis of multiple etiologies while restoring the dysbiosis of gut microbiota is attractive. Here, Aurozyme, a novel nanomedicine comprised of gold nanoparticles (AuNPs) and glycyrrhizin (GL) with a glycol chitosan coating layer, as a promising approach for colitis, is demonstrated. The unique feature of Aurozyme is the conversion of harmful peroxidase‐like activity of AuNPs to beneficial catalase‐like activity due to the amine‐rich environment provided by the glycol chitosan. This conversion process enables Aurozyme to oxidize the hydroxyl radicals derived from AuNP, producing water and oxygen molecules. In fact, Aurozyme effectively scavenges reactive oxygen/reactive nitrogen species (ROS/RNS) and damage‐associated molecular patterns (DAMPs), which can attenuate the M1 polarization of macrophage. It exhibits prolonged adhesion to the lesion site, promoting sustained anti‐inflammatory effects and restoring intestinal function in colitis‐challenged mice. Additionally, it increases the abundance and diversity of beneficial probiotics, which are essential for maintaining microbial homeostasis in the gut. The work highlights the transformative potential of nanozymes for the comprehensive treatment of inflammatory disease and represents an innovative switching technology of enzyme‐like activity by Aurozyme.
Droplet Manipulation on Bioinspired Slippery Surfaces: From Design Principle to Biomedical Applications
Authors: Wang Xuejiao , Zhuang Zhicheng , Li Xin , Yao Xi 
Published: May 2023

AbstractDroplet manipulation with high efficiency, high flexibility, and programmability, is essential for various applications in biomedical sciences and engineering. Bioinspired liquid‐infused slippery surfaces (LIS), with exceptional interfacial properties, have led to expanding research for droplet manipulation. In this review, an overview of actuation principles is presented to illustrate how materials or systems can be designed for droplet manipulation on LIS. Recent progress on new manipulation methods on LIS is also summarized and their prospective applications in anti‐biofouling and pathogen control, biosensing, and the development of digital microfluidics are presented. Finally, an outlook is made on the key challenges and opportunities for droplet manipulation on LIS.
Scalable Production of 2D Minerals by Polymer Intercalation and Adhesion for Multifunctional Applications
Authors: Wang Zhongyue , Yang Liusi , Dai Lixin , Huang Ziyang , Wu Keyou , Liu Bilu 
Published: May 2023

AbstractNatural and sustainable 2D minerals have many unique properties and may reduce reliance on petroleum‐based products. However, the large‐scale production of 2D minerals remains challenging. Herein, a green, scalable, and universal polymer intercalation and adhesion exfoliation (PIAE) method to produce 2D minerals such as vermiculite, mica, nontronite, and montmorillonite with large lateral sizes and high efficiency, is developed. The exfoliation relies on the dual functions of polymers involving intercalation and adhesion to expand interlayer space and weaken interlayer interactions of minerals, facilitating their exfoliation. Taking vermiculite as an example, the PIAE produces 2D vermiculite with an average lateral size of 1.83 ± 0.48 µm and thickness of 2.40 ± 0.77 nm at a yield of ≈30.8%, surpassing state‐of‐the‐art methods in preparing 2D minerals. Flexible films are directly fabricated by the 2D vermiculite/polymer dispersion, exhibiting outstanding performances including mechanical strength, thermal resistance, ultraviolet shielding, and recyclability. The representative application of colorful multifunctional window coatings in sustainable buildings is demonstrated, indicating the potential of massively produced 2D minerals.
Optimization of carbon dioxide absorption in a continuous bubble column reactor using response surface methodology
Authors: Gul Ayşe , Derakhshandeh Masoud , Un Umran Tezcan 
Published: May 2023

AbstractCarbon dioxide absorption using amine based solvents is a well‐known approach for carbon dioxide removal. Especially with the increasing concerns about greenhouse gas emissions, there is a need for an optimization approach capable of multifactor calibration and prediction of interactions. Since conventional methods based on empirical relations are not efficiently applicable, this study investigates use of Response Surface Methodology as a strong optimization tool. A bubble column reactor was used and the effect of solvent concentration (10.0, 20.0 and 30.0 vol%), flow rate (4.0, 5.0 and 6.0 L min−1), diffuser pore size (0.5, 1.0 and 1.5 mm) and temperature (20.0, 25.0 and 30.0°C) on the absorption capacity and also overall mass transfer coefficient was evaluated. The optimization results for maintaining maximum capacity and overall mass transfer coefficient revealed that different optimization targets led to different tuned operational factors. Overall mass transfer coefficient decreased to 34.7 min−1 when the maximum capacity was the desired target. High reaction rate along with the highest absorption capacity was set as desirable two factor target in this application. As a result, a third scenario was designed to maximize both mass transfer coefficient and absorption capacity simultaneously. The optimized condition was achieved when a gas flow rate of 5.9 L min−1, MEA solution of 29.6 vol%, diffuser pore size of 0.5 mm and temperature of 20.6°C was adjusted. At this condition, mass transfer coefficient reached a maximum of 38.4 min−1, with a forecasted achievable absorption capacity of 120.5 g CO2 per kg MEA.
Accelerating diversity in Alzheimer's disease research by partnering with a community advisory board
Authors: Pena‐Garcia Alex , Richards Ralph , Richards Mollie , Campbell Christopher , Mosley Hank , Asper Joseph , Eliacin Johanne , Polsinelli Angelina , Apostolova Liana , Hendrie Hugh , Tackett Andrew , Elliott Caprice , Van Heiden Sarah , Gao Sujuan , Saykin Andrew , Wang Sophia ,   IADRC CAB
Published: May 2023

AbstractIntroductionCommunity advisory boards (CABs) and researcher partnerships present a promising opportunity to accelerate enrollment of underrepresented groups (URGs). We outline the framework for how the CAB and researchers at the Indiana Alzheimer's Disease Research Center (IADRC) partnered to accelerate URG participation in AD neuroimaging research.MethodsCAB and the IADRC researchers partnered to increase the CAB's impact on URG study enrollment through community and research interactions. Community interactions included the CAB collaboratively building a network of URG focused community organizations and collaborating with those URG‐focused organizations to host IADRC outreach and recruitment events. Research interactions included direct impact (CAB members referring themselves or close contacts as participants) and strategic impact, mainly by the CAB working with researchers to develop and refine URG focused outreach and recruitment strategies for IADRC and affiliated studies to increase URG representation. We created a database infrastructure to measure how these interactions impacted URG study enrollment.ResultsOut of the 354 URG research referrals made to the IADRC between October 2019 and December 2022, 267 referrals were directly referred by the CAB (N= 36) or from community events in which CAB members organized and/or volunteered at (N= 231). Out of these 267 referrals, 34 were enrolled in IADRC and 2 were enrolled in Indiana University Longitudinal Early Onset AD Study (IU LEADS). Of note, both studies require the prospective participants to be willing to do MRI and PET scans. As of December 2022, 30 out of the 34 enrolled participants have received a consensus diagnosis; the majority were cognitively normal (64.7%), with the remainder having mild cognitive impairment (17.6%) or early‐stage AD (2.9%).DiscussionThe IADRC CAB‐researcher partnership had a measurable impact on the enrollment of African American/Black adults in AD neuroimaging studies. Future studies will need to test whether this conceptual model works for other sites and for other URGs.
Elevating Poetry Writing with Southeast Asian Refugee Children's Picture Books
Authors: Gill Victoria , Enriquez Grace 
Published: May 2023

AbstractIn this column, we demonstrate ways to connect four commonly taught poetic genres to better explore the intersectionalities (The University of Chicago Legal Forum;140:139–167, 1989; Black feminist thought: Knowledge, consciousness, and the politics of empowerment, 1990) in the texts and students’ own lives through two cultural insider‐created (A map into the world, 2019; Wishes, 2021) Southeast Asian (SEA) children's picturebooks about the refugee experience. In doing so, we show how students can write poetry as maps and wishes with picturebooks about the maps and wishes in the lives of SEA refugees.
Introduction: EU Support for Peace in Colombia. Territorial Approach, Strengthening Civil Society and Human Rights
Authors: Pérez de Armiño Karlos 
Published: May 2023

AbstractThis first chapter provides an introduction to the book as a whole. In the first place, it offers a general view of the historical context and the contents of the Havana Peace Agreement signed in 2016 between the Colombian government and the guerrilla organization FARC-EP. It also outlines the areas and instruments in which the EU’s support for this Agreement is materialized, as well as the motivations behind this support. These include the EU’s wish to project itself as a normative power, as well as interests of an economic and political type, and the search for regional stability. Additionally, the chapter defines the starting points and the transversal axes around which the book as a whole is articulated, referring to the three fields in which we consider that the EU’s activities in Colombia have been making several innovative contributions enabling it to move beyond conventional liberal peace: the strengthening of civil society, the promotion and defense of human rights, and the adoption of a territorial approach. Equally, the text provides a brief theoretical framework for the book, pointing to some theoretical debates in Peace Studies that could be enriched by the European experience in Colombia.