bluuebunny/crossref_metadata_2025_split huggingface dataset:
Becoming a Virtuosa: Advice from Vienna, 1769
Authors: Beesley Clare 
Published: August 2023

AbstractFirst-hand accounts explaining how a young British virtuosa went about establishing an international career in the later eighteenth century are scant. However, a previously unstudied handwritten page contained within the Rackett Family of Spettisbury Archive at the Dorset History Centre provides new insights into this underexplored area. In this article, I examine an anonymous 1769 document entitled ‘a Vienne’ from which the guiding voices of eminent musicians at the Vienna court, including Johann Adolf Hasse, Faustina Bordoni, Marianna Martines and their circle, emerge. I argue that this item is in fact an aide-mémoire memorializing intimate glimpses of private conversations, career-shaping advice and impressions that helped mould its author into a virtuosa. Further, by means of palaeographical and biographical evidence I identify the author as the young British glass-armonica player Marianne Davies and assert that her recollections, preserved in this hitherto overlooked piece of ephemera, reconstruct how the educational process of becoming a virtuosa took place.
The Making of Jamaica's ‘First Composer’: Rethinking Samuel Felsted
Authors: Weaver Wayne 
Published: August 2023

AbstractThis article examines the links between the music of Anglo-Jamaican organist and composer Samuel Felsted (1743–1802) and his environment of late eighteenth-century Kingston, building on research published since the 1980s. Although Felsted, a person of English-American heritage who was born in Jamaica, was part of the island's European-origin community, most of his local contemporaries were people of African descent. Like many of his friends, family members and acquaintances, Felsted was a slave owner, and, as I argue here, his various literary and artistic outputs demonstrate how he was influenced by the kinds of issues – such as slavery, servitude, sovereignty and nationhood – that surfaced in the public and private discourses of his time. Considering what Felsted's cultural legacy might mean today, I turn to his undated and virtually unknown oratorio The Dedication, for which he wrote both the text and the music. The Dedication contains literary themes that allow its connections to Felsted's world and its setting of ancient Babylon to be explored. I also suggest the early 1790s as a possible time of composition for this work.
Energetic Neutral Atom (ENA) Emission Characteristics at the Moon and Mercury From 3D Regolith Simulations of Solar Wind Reflection
Authors: Szabo P. S. , Poppe A. R. , Mutzke A. , Fatemi S. , Vorburger A. , Wurz P. 
Published: August 2023

AbstractThe reflection of solar wind protons as energetic neutral atoms (ENAs) from the lunar surface has regularly been used to study the plasma‐surface interaction at the Moon. However, there still exists a fundamental lack of knowledge of the scattering process. ENA emission from the surface is expected to similarly occur at Mercury and will be studied by BepiColombo. Understanding this solar wind backscattering will allow studies of both Mercury's plasma environment as well as properties of the hermean surface itself. Here, we expand on previous simulation studies of the solar‐wind‐regolith interaction with 3D grains in SDTrimSP‐3D to compare the predicted scattering energies and angles to ENA measurements from the Moon by the Chandrayaan‐1 and IBEX missions. The simulations reproduce a backward emission toward the Sun, which can be connected to the geometry of the regolith grain stacking. In contrast, the ENA energy distribution and its Maxwellian shape is mostly connected to the solar wind velocity. Our simulations also correctly describe a lunar ENA albedo between 10% and 20% and support its decrease with solar wind velocity. We further expand our studies to illustrate how BepiColombo will be able to observe ENAs at Mercury using hybrid simulations of Mercury's magnetosphere as an input for the complex surface precipitation patterns. We demonstrate that the variable ion precipitation will directly influence ENA emission from the surface. The orbits of BepiColombo's Mercury Planetary Orbiter and Mercury Magnetospheric Orbiter/Mio spacecraft are shown to be suitable to observe ENA emission patterns both on a local and a global scale.
Deciduous Tundra Shrubs Shift Toward More Acquisitive Light Absorption Strategy Under Climate Change Treatments
Authors: Heim R. J. , Iturrate‐Garcia M. , Reji Chacko M. , Karsanaev S. , Maximov T. C. , Heijmans M. M. P. D. , Schaepman‐Strub G. 
Published: August 2023

AbstractThe effects of climate change on plants are particularly pronounced in the Arctic region. Warming relaxes the temperature and nutrients boundaries that limit tundra plant growth. Increased resource availability under future climate conditions may induce a shift from a conservative economic strategy to an acquisitive one. Following the leaf economics spectrum that hypothesizes a strategy gradient between survival, plant size and costs for the photosynthetic leaf area, light absorption of tundra plants may increase. We investigated climate change effects on light absorptance and the relationship between light absorptance (fraction of absorbed photosynthetically active radiation, FAPAR) and structural and nutritional leaf traits, performing a soil warming and surface soil fertilization experiment on two deciduous tundra shrub species. Our results show that fertilization and warming combined increase light absorptance in Arctic shrubs and that FAPAR is correlated with leaf nutrients but not with structural leaf traits. This indicates an economic strategy shift of shrubs from conservative to acquisitive induced by warming and fertilization combined. We found species‐specific differences: FAPAR was influenced by warming alone in Betula nana but not in Salix pulchra, and FAPAR was correlated with leaf phosphorus in B. nana but not in S. pulchra. We attribute this to water limitation of B. nana that generally grows in drier areas within the study site compared to S. pulchra. We conclude that FAPAR is a measure that opens up more possibilities to estimate nutritional leaf traits and nutrient cycles, plant economic strategies, and ecological feedbacks of the tundra ecosystem on broader scales.
Phonon engineering in Yb:La2CaB10O19 crystal for extended lasing beyond the fluorescence spectrum
Authors: Cheng Yanling , Liang Fei , Lu Dazhi , Feng Jingcheng , Zhang Guochun , Yu Haohai , Zhang Huaijin , Wu Yicheng 
Published: August 2023

AbstractSince the first invention of the laser in 1960, direct lasing outside the fluorescence spectrum is deemed impossible owing to the “zero-gain” cross-section. However, when electron-phonon coupling meets laser oscillation, an energy modulation by the quantized phonon can tailor the electronic transitions, thus directly creating some unprecedented lasers with extended wavelengths by phonon engineering. Here, we demonstrate a broadband lasing (1000–1280 nm) in a Yb-doped La2CaB10O19 (Yb:LCB) crystal, far beyond its spontaneous fluorescence spectrum. Numerical calculations and in situ Raman verify that such a substantial laser emission is devoted to the multiphonon coupling to lattice vibrations of a dangling “quasi-free-oxygen” site, with the increasing phonon numbers step-by-step (n = 1–6). This new structural motif provides more alternative candidates with strong-coupling laser materials. Moreover, the quantitative relations between phonon density distribution and laser wavelength extension are discussed. These results give rise to the search for on-demand lasers in the darkness and pave a reliable guideline to study those intriguing electron-phonon-photon coupled systems for integrated photonic applications.
Negative symptoms and cognitive impairment are associated with distinct motivational deficits in treatment resistant schizophrenia
Authors: Saleh Y. , Jarratt-Barnham I. , Petitet P. , Fernandez-Egea E. , Manohar S. G. , Husain M. 
Published: August 2023

Abstract
Background
Motivational deficits are a central feature of the negative syndrome in schizophrenia. They have consistently been associated with reduced willingness to expend physical effort in return for monetary rewards on effort based decision making (EBDM) paradigms. Nevertheless, the mechanisms underlying such altered performance are not well characterised, and it remains unclear if they are driven purely by negative symptoms, or also in part by cognitive impairment, antipsychotic treatment or even positive symptoms. Here we investigated the impact of all these factors using a paradigm that has not previously been used to measure EBDM in schizophrenia.

Methods
Forty treatment resistant schizophrenia (TRS) patients on clozapine and matched controls (N = 80) completed a well validated EBDM task which offers monetary rewards in return for physical effort. Choice and reaction time data was analysed using logistic regressions, as well as Bayesian hierarchical drift diffusion modelling (HDDM). Behavioural parameters were compared between groups and their association with negative symptoms, cognitive function and serum clozapine levels were assessed.

Results
Overall, TRS patients accepted significantly less offers than controls during effort-based decision making, suggesting they were less motivated. They demonstrated reduced sensitivity to increasing rewards, but surprisingly were also less averse to increasing effort. Despite a positive correlation between negative symptoms and cognitive function in TRS, reward sensitivity was associated only with cognitive performance. In contrast, reduced effort aversion correlated with negative symptom severity. Clozapine levels and positive symptoms were not associated with either behavioural parameter.

Conclusion
Motivational deficits in TRS are characterised by both diminished reward sensitivity and reduced effort aversion during EBDM. Cognitive dysfunction and negative symptom severity account for distinct aspects of these behavioural changes, despite positive associations between themselves. Overall, these findings demonstrate that negative symptoms and cognitive impairment have significant independent contributions to EBDM in TRS, thereby opening the possibility of individualised treatment targeting these mechanisms to improve motivation.
N6-methyladenosine modification of REG1α facilitates colorectal cancer progression via β-catenin/MYC/LDHA axis mediated glycolytic reprogramming
Authors: Zhou Mingxia , He Jing , Li Yingxia , Jiang Libin , Ran Jiaxuan , Wang Chang , Ju Chenxi , Du Dan , Xu Xinyu , Wang Xuexin , Li Hongle , He Fucheng , Wen Hongtao 
Published: August 2023

AbstractAerobic glycolysis has been considered as a hallmark of colorectal cancer (CRC). However, the potential functional regulators of glycolysis in CRC remains to be elucidated. In the current study, we found that Regenerating islet-derived protein 1-alpha (REG1α) was significantly increased in both CRC tissues and serum, and positively associated with CRC patients’ lymph node metastasis, advanced tumor stage, and unfavorable prognosis. Ectopic expression of REG1α contributed to various tumorigenic properties, including cell proliferation, cell cycle, migration, invasion, and glycolysis. In contrast, REG1α deficiency in CRC cells attenuated malignant properties and glucose metabolism. Mechanically, REG1α promoted CRC proliferation and metastasis via β-catenin/MYC axis-mediated glycolysis upregulation. Moreover, the malignant behaviors governed by REG1α could be effectively abolished by silencing of Wnt/β-catenin/MYC axis or glycolysis process using specific inhibitors. Besides, REG1α expression was mediated by METTL3 in an m6A-dependent manner. Overall, our work defines a novel regulatory model of the METTL3/REG1α/β-catenin/MYC axis in CRC, which indicates that REG1α could function as a novel biomarker and a potential therapeutic target for patients with CRC.
The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling
Authors: Shi Jian , Miao Daojia , Lv Qingyang , Wang Keshan , Wang Qi , Liang Huageng , Yang Hongmei , Xiong Zhiyong , Zhang Xiaoping 
Published: August 2023

AbstractMetabolic reprogramming is a hallmark of cancer, and the impact of lipid metabolism as a crucial aspect of metabolic reprogramming on clear cell renal cell carcinoma (ccRCC) progression has been established. However, the regulatory mechanisms underlying the relationship between metabolic abnormalities and ccRCC progression remain unclear. Therefore, this study aimed to identify key regulatory factors of metabolic reprogramming in ccRCC and provide potential therapeutic targets for ccRCC patients. Potential metabolic regulatory factors in ccRCC were screened using bioinformatics analysis. Public databases and patient samples were used to investigate the aberrant expression of Oxoglutarate dehydrogenase-like (OGDHL) in ccRCC. The function of OGDHL in ccRCC growth and metastasis was evaluated through in vitro and in vivo functional experiments. Mechanistic insights were obtained through luciferase reporter assays, chromatin immunoprecipitation, RNA methylation immunoprecipitation, and mutagenesis studies. OGDHL mRNA and protein levels were significantly downregulated in ccRCC tissues. Upregulation of OGDHL expression effectively inhibited ccRCC growth and metastasis both in vitro and in vivo. Furthermore, FTO-mediated OGDHL m6A demethylation suppressed its expression in ccRCC. Mechanistically, low levels of OGDHL promoted TFAP2A expression by inhibiting ubiquitination levels, which then bound to the FASN promoter region and transcriptionally activated FASN expression, thereby promoting lipid accumulation and ERK pathway activation. Our findings demonstrate the impact of OGDHL on ccRCC progression and highlight the role of the FTO/OGDHL/TFAP2A/FASN axis in regulating ccRCC lipid metabolism and progression, providing new targets for ccRCC therapy.
Prominent Josephson tunneling between twisted single copper oxide planes of Bi2Sr2-xLaxCuO6+y
Authors: Wang Heng , Zhu Yuying , Bai Zhonghua , Wang Zechao , Hu Shuxu , Xie Hong-Yi , Hu Xiaopeng , Cui Jian , Huang Miaoling , Chen Jianhao , Ding Ying , Zhao Lin , Li Xinyan , Zhang Qinghua , Gu Lin , Zhou X. J. , Zhu Jing , Zhang Ding , Xue Qi-Kun 
Published: August 2023

AbstractJosephson tunneling in twisted cuprate junctions provides a litmus test for the pairing symmetry, which is fundamental for understanding the microscopic mechanism of high temperature superconductivity. This issue is rekindled by experimental advances in van der Waals stacking and the proposal of an emergent d+id-wave. So far, all experiments have been carried out on Bi2Sr2CaCu2O8+x (Bi-2212) with double CuO2 planes but show controversial results. Here, we investigate junctions made of Bi2Sr2-xLaxCuO6+y (Bi-2201) with single CuO2 planes. Our on-site cold stacking technique ensures uncompromised crystalline quality and stoichiometry at the interface. Junctions with carefully calibrated twist angles around 45° show strong Josephson tunneling and conventional temperature dependence. Furthermore, we observe standard Fraunhofer diffraction patterns and integer Fiske steps in a junction with a twist angle of 45.0±0.2°. Together, these results pose strong constraints on the d or d+id-wave pairing and suggest an indispensable isotropic pairing component.
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression
Authors: Bailey Peter , Ridgway Rachel A. , Cammareri Patrizia , Treanor-Taylor Mairi , Bailey Ulla-Maja , Schoenherr Christina , Bone Max , Schreyer Daniel , Purdie Karin , Thomson Jason , Rickaby William , Jackstadt Rene , Campbell Andrew D. , Dimonitsas Emmanouil , Stratigos Alexander J. , Arron Sarah T. , Wang Jun , Blyth Karen , Proby Charlotte M. , Harwood Catherine A. , Sansom Owen J. , Leigh Irene M. , Inman Gareth J. 
Published: August 2023

AbstractThe molecular basis of disease progression from UV-induced precancerous actinic keratosis (AK) to malignant invasive cutaneous squamous cell carcinoma (cSCC) and potentially lethal metastatic disease remains unclear. DNA sequencing studies have revealed a massive mutational burden but have yet to illuminate mechanisms of disease progression. Here we perform RNAseq transcriptomic profiling of 110 patient samples representing normal sun-exposed skin, AK, primary and metastatic cSCC and reveal a disease continuum from a differentiated to a progenitor-like state. This is accompanied by the orchestrated suppression of master regulators of epidermal differentiation, dynamic modulation of the epidermal differentiation complex, remodelling of the immune landscape and an increase in the preponderance of tumour specific keratinocytes. Comparative systems analysis of human cSCC coupled with the generation of genetically engineered murine models reveal that combinatorial sequential inactivation of the tumour suppressor genesTgfbr2,Trp53, andNotch1coupled with activation of Ras signalling progressively drives cSCC progression along a differentiated to progenitor axis. Taken together we provide a comprehensive map of the cSCC disease continuum and reveal potentially actionable events that promote and accompany disease progression.
Architecture of the Heme-translocating CcmABCD/E complex required for Cytochrome c maturation
Authors: Ilcu Lorena , Denkhaus Lukas , Brausemann Anton , Zhang Lin , Einsle Oliver 
Published: August 2023

AbstractMono- and multiheme cytochromes c are post-translationally matured by the covalent attachment of heme. For this, Escherichia coli employs the most complex type of maturation machineries, the Ccm-system (for cytochrome cmaturation). It consists of two membrane protein complexes, one of which shuttles heme across the membrane to a mobile chaperone that then delivers the cofactor to the second complex, an apoprotein:heme lyase, for covalent attachment. Here we report cryo-electron microscopic structures of the heme translocation complex CcmABCD from E. coli, alone and bound to the heme chaperone CcmE. CcmABCD forms a heterooctameric complex centered around the ABC transporter CcmAB that does not by itself transport heme. Our data suggest that the complex flops a heme group from the inner to the outer leaflet at its CcmBC interfaces, driven by ATP hydrolysis at CcmA. A conserved heme-handling motif (WxWD) at the periplasmic side of CcmC rotates the heme by 90° for covalent attachment to the heme chaperone CcmE that we find interacting exclusively with the CcmB subunit.
PINK1 and Parkin regulate IP3R-mediated ER calcium release
Authors: Ham Su Jin , Yoo Heesuk , Woo Daihn , Lee Da Hyun , Park Kyu-Sang , Chung Jongkyeong 
Published: August 2023

AbstractAlthough defects in intracellular calcium homeostasis are known to play a role in the pathogenesis of Parkinson’s disease (PD), the underlying molecular mechanisms remain unclear. Here, we show that loss of PTEN-induced kinase 1 (PINK1) and Parkin leads to dysregulation of inositol 1,4,5-trisphosphate receptor (IP3R) activity, robustly increasing ER calcium release. In addition, we identify that CDGSH iron sulfur domain 1 (CISD1, also known as mitoNEET) functions downstream of Parkin to directly control IP3R. Both genetic and pharmacologic suppression of CISD1 and its Drosophila homolog CISD (also known as Dosmit) restore the increased ER calcium release in PINK1 and Parkin null mammalian cells and flies, respectively, demonstrating the evolutionarily conserved regulatory mechanism of intracellular calcium homeostasis by the PINK1-Parkin pathway. More importantly, suppression of CISD in PINK1 and Parkin null flies rescues PD-related phenotypes including defective locomotor activity and dopaminergic neuronal degeneration. Based on these data, we propose that the regulation of ER calcium release by PINK1 and Parkin through CISD1 and IP3R is a feasible target for treating PD pathogenesis.
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
Authors: Hendrix Sebastian , Kingma Jenina , Ottenhoff Roelof , Valiloo Masoud , Svecla Monika , Zijlstra Lobke F. , Sachdev Vinay , Kovac Kristina , Levels Johannes H. M. , Jongejan Aldo , de Boer Jan F. , Kuipers Folkert , Rimbert Antoine , Norata Giuseppe D. , Loregger Anke , Zelcer Noam 
Published: August 2023

AbstractThe sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post-transcriptional regulator of SREBP activation. Constitutive or inducible global ablation of Spring in mice is not tolerated, and we therefore develop liver-specific Spring knockout mice (LKO). Transcriptomics and proteomics analysis reveal attenuated SREBP signaling in livers and hepatocytes of LKO mice. Total plasma cholesterol is reduced in male and female LKO mice in both the low-density lipoprotein and high-density lipoprotein fractions, while triglycerides are unaffected. Loss of Spring decreases hepatic cholesterol and triglyceride content due to diminished biosynthesis, which coincides with reduced very-low-density lipoprotein secretion. Accordingly, LKO mice are protected from fructose diet-induced hepatosteatosis. In humans, we find common genetic SPRING variants that associate with circulating high-density lipoprotein cholesterol and ApoA1 levels. This study positions SPRING as a core component of hepatic SREBP signaling and systemic lipid metabolism in mice and humans.
A frontal transcallosal inhibition loop mediates interhemispheric balance in visuospatial processing
Authors: Wang Yanjie , Chen Zhaonan , Ma Guofen , Wang Lizhao , Liu Yanmei , Qin Meiling , Fei Xiang , Wu Yifan , Xu Min , Zhang Siyu 
Published: August 2023

AbstractInterhemispheric communication through the corpus callosum is required for both sensory and cognitive processes. Impaired transcallosal inhibition causing interhemispheric imbalance is believed to underlie visuospatial bias after frontoparietal cortical damage, but the synaptic circuits involved remain largely unknown. Here, we show that lesions in the mouse anterior cingulate area (ACA) cause severe visuospatial bias mediated by a transcallosal inhibition loop. In a visual-change-detection task, ACA callosal-projection neurons (CPNs) were more active with contralateral visual field changes than with ipsilateral changes. Unilateral CPN inactivation impaired contralateral change detection but improved ipsilateral detection by altering interhemispheric interaction through callosal projections. CPNs strongly activated contralateral parvalbumin-positive (PV+) neurons, and callosal-input-driven PV+ neurons preferentially inhibited ipsilateral CPNs, thus mediating transcallosal inhibition. Unilateral PV+ neuron activation caused a similar behavioral bias to contralateral CPN activation and ipsilateral CPN inactivation, and bilateral PV+ neuron activation eliminated this bias. Notably, restoring interhemispheric balance by activating contralesional PV+ neurons significantly improved contralesional detection in ACA-lesioned animals. Thus, a frontal transcallosal inhibition loop comprising CPNs and callosal-input-driven PV+ neurons mediates interhemispheric balance in visuospatial processing, and enhancing contralesional transcallosal inhibition restores interhemispheric balance while also reversing lesion-induced bias.