bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac dose in the treatment of synchronous bilateral breast cancer patients between three different radiotherapy techniques (VMAT, IMRT, and 3D CRT)
Authors: Salim Nidal , Popodko Alexey , Tumanova Kristina , Stolbovoy Alexandr , Lagkueva Irina , Ragimov Vadim 
Published: March 2023

Abstract
Purpose
Synchronous bilateral irradiation of both mammary glands and chest wall is a challenging task due to technical difficulties and limited evidence supporting an optimal technique to improve treatment outcomes. We studied and compared the dosimetry data of three radiotherapy techniques to select the most optimal one.

Methods
We compared three-dimensional conformal radiation treatment (3D CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT) during irradiation of synchronous bilateral breast cancer in nine patients followed by examination of dose distribution to the cardiac conduction system (SA node, AV node and Bundle of His), myocardium, lungs, left anterior descending artery (LADA) and right coronary artery (RCA) .

Results
VMAT is the most sparing technique for SBBC treatment. Even though doses to the SA node, AV node and Bundle of His were higher with VMAT (Dmean were 3.75 ± 0.62, 2.58 ± 0.83 and 3.03 ± 1.18 Gy respectively) compared with 3D CRT (Dmean were 2.61 ± 0.66, 1.52 ± 0.38 and 1.88 ± 0.70 Gy respectively), this difference is statistically insignificant. Doses to the right and left lung (average Dmean = 12.65 ± 3.20 Gy, V20Gy = 24.12 ± 6.25%), myocardium (Dmean = 5.33 ± 1.51 Gy, V10Gy = 9.80 ± 3.83%, V20Gy = 7.19 ± 3.15%, V25Gy = 6.20 ± 2.93%), and LADA (Dmean = 10.04 ± 4.92 Gy, V20Gy = 18.17 ± 13.24% and V25Gy = 15.41 ± 12.19%) were highest with 3D CRT. The highest Dmean in the cardiac conduction system (5.30 ± 2.23, 3.15 ± 1.61 and 3.89 ± 1.85 Gy respectively) was observed with IMRT, and a similar effect was noted in RCA (Dmean = 7.48 ± 2.11 Gy).

Conclusion
VMAT is the optimal and satisfactory radiation therapy technique for sparing organs at risk (OARs). With VMAT, a lower Dmean value was noted in the myocardium, LADA, and lungs. The use of 3D CRT significantly increases the dose of radiation reaching the lungs, myocardium, and LADA, which can subsequently cause cardiovascular and lung complications, but not in the cardiac conduction system.
Modeling variability of infiltration tests in ephemeral stream beds as a random function for uncertainty quantification
Authors: Niyazi Burhan , Masoud Milad , Elfeki Amro , Rajmohan Natarajan , Alqarawy Abdulaziz , Rashed Mohamed 
Published: March 2023

AbstractInfiltration processes are highly variable in space and time, and therefore, building reliable hydrological models without considering the variability is questionable. In this research, we propose a methodology that can systematically handle the variability in the infiltration process. The methodology is based on the theory of random functions in a dimensionless formalism that allows the derivation of a generalized model from the observed infiltration test data. The Monte Carlo technique is utilized to generate hypothetical infiltration tests that carputer the characteristics of the real tests. The methodology is applied to a case study in ephemeral stream beds located in Al Madinah Al Munawarah Province in Saudi Arabia. The measurements are made by the double-ring infiltrometer. Beta distribution fits the dimensionless cumulative infiltration relatively well at a 1% significant level at all times, and therefore, it can be used to model the uncertainty in hydrological modeling. High variability is observed in infiltration tests at the early time (a platykurtic distribution with high dispersion); however, it decreases at the late time (Leptokurtic distribution with low dispersion) since the infiltration reaches a steady infiltration. Some extreme tests show different behavior from the fourteen tests that cannot be captured by the model and therefore need special treatment.
Sensitive analysis of meteorological data and selecting appropriate machine learning model for estimation of reference evapotranspiration
Authors: Adib Arash , Kalantarzadeh Seyed Shahab Oddin , Shoushtari Mohammad Mahmoudian , Lotfirad Morteza , Liaghat Ali , Oulapour Masoud 
Published: March 2023

AbstractThis study applies three methods, Gene Expression Programming (GEP), M5 tree (M5T) model and optimized Artificial Neural Network by Genetic Algorithm (ANN-GA) for estimation of reference evapotranspiration in Ahvaz and Dezful in the southwest of Iran. Comparison between results of the FAO Penman-Monteith (FPM) method and the mentioned three methods shows that ANN-GA with the Levenberg-Marquardt training method is the best method and the M5T model is the second appropriate method for estimation of reference evapotranspiration. In Ahvaz, R2 and RMSE of ANN-GA method are 0.996, 0.184 mm/day. For M5T method, these values are 0.997 and 0259 mm/day, and for GEP method, they are 0.979 and 0.521 mm/day. In Dezful, R2 and RMSE of ANN-GA method are 0.994, 0.235 mm/day. For M5T method, these values are 0.992 and 0265 mm/day, and for GEP method, they are 0.963 and 0.544 mm/day. In addition, sensitivity analysis shows that the maximum temperature is the most effective parameter, and the wind speed is second effective parameter. In Dezful, the effect of the maximum temperature is more than those of Ahvaz but the effect of wind speed is less than those of Ahvaz. Because Ahvaz is more flatter than Dezful (the movement of wind in Ahvaz is freer than those of Dezful). The third effective meteorological parameter is the average relative humidity in Ahvaz and the sunny hours in Dezful. The reason for this subject is the less distant of Ahvaz from the Persian Gulf (it is source of moisture).
Oncoplastic level II volume displacement surgery for breast cancer: oncological and aesthetic outcomes
Authors: Sparavigna Marco , Gipponi Marco , Carmisciano Luca , Franchelli Simonetta , Atzori Giulia , Cornacchia Chiara , Diaz Raquel , Murelli Federica , Depaoli Francesca , Friedman Daniele , Fregatti Piero 
Published: March 2023

AbstractOncoplastic breast-conserving surgery (OBCS) is increasingly used to treat breast cancer with the dual purpose of performing a radical oncological resection while minimizing the risk of post-operative deformities. The aim of the study was to evaluate the patient outcomes after Level II OBCS as regards oncological safety and patient satisfaction. Between 2015 and 2020, a cohort of 109 women consecutively underwent treatment for breast cancer with bilateral oncoplastic breast-conserving volume displacement surgery; patient satisfaction was measured with BREAST-Q questionnaire. The 5-year overall survival and disease-free survival were 97% (95%CI 92, 100) and 94% (95%CI 90, 99), respectively. In two patients (1.8%), mastectomy was finally performed due to margin involvement. The median patient-reported score for “satisfaction with breast” (BREAST-Q) was 74/100. Factors associated with a lower aesthetic satisfaction index included: location of tumour in central quadrant (p = 0.007); triple negative breast cancer (p = 0.045), and re-intervention (p = 0.044). OBCS represents a valid option in terms of oncological outcomes for patients otherwise candidate to more extensive breast conserving surgery; the high satisfaction index also suggests a superiority in terms of aesthetic outcomes.
The Metaverse: Surveillant Physics, Virtual Realist Governance, and the Missing Commons
Authors: McStay Andrew 
Published: March 2023

AbstractThis paper argues that there are value and design-based problems in current ambitions for the Metaverse. With the Metaverse deepening longstanding commercial surveillance practices, the paper focuses on data protection harms from biometric and emotion data, the gauging of first-person perspectives, and sensitivities around profiling of avatars. The paper advances two notions to address harms and data protection:surveillant physicsandvirtual realist governance.Surveillant physicsrefers to surveillance informing the laws of how that reality operates: this is a useful concept given the granular control that platforms have over virtual worlds and the laws by which they function.Virtual realist governancebuilds on the longstanding principle of virtual realism and David Chalmer’s recent theorising of Reality+ that demands that the virtual is taken to be real, meaning that experiences of virtual objects and what occurs in-world are treated as meaningful. The paper progresses to further consider governance questions, both around technical and ethical standards, but also data protection ideas such as personal data stores, and data trusts, that were not conceived as Metaverse-based ideas, but have greater chance of being realised as basic premises of the Metaverse are being designed. Although this paper is regretfully pessimistic, finding that a root problem of current ambitions for the Metaverse is that the public good and the commons are missing, it sees virtual realist scope for modes of resistance unseen in other digital realms.
Disparate continental scale patterns in floral host breadth of Australian colletid bees (Colletidae: Hymenoptera)
Authors: Slattery Patricia S. , Parslow Ben A. , Lee Michael S. Y. , Batley Michael , Walker Ken L. , Schwarz Michael P. 
Published: March 2023

AbstractPlant-bee networks are rarely, if ever, studied quantitatively at continental scales, yet these have the potential to inform how biota and ecosystems are assembled beyond narrower regional biomes. The short-tongued bee family Colletidae comprises the major component of bee diversity in Australia, with three key subfamilies: the Neopasiphaeinae, Hylaeinae, and Euryglossinae. We use museum data (> 27,000 records) to record binary interactions between these bees (from each of these subfamilies, resolved to subgenera) and plants (resolved to genera). The resulting networks were analysed using bipartite graphs and associated indices of network structure. The three bee subfamilies showed markedly different network structures with their floral hosts. Euryglossinae had strong interactions with Myrtaceae and an otherwise relatively narrow host breadth, Neopasiphaeinae had little signal of host specialisation above genera and a very broad host breadth, and Hylaeinae appeared intermediate in network structure. Furthermore, Euryglossinae is more speciose within Australia (404 species, or ~ 25% of described Australian bee fauna) than Hylaeinae and Neopasiphaeinae, but these differences do not correspond to the stem ages of the three subfamilies, suggesting that time-since-origin does not explain bee species diversity or floral host breadth. Patterns of host breadth persist after rarefaction analyses that correct for differing numbers of observation records. We suggest that visitation networks could be influenced by evolutionary constraints to expansion of floral host breadth, but it is also possible that many bee-plant interactions are shaped by bees exploiting floral traits that are driven by non-bee fauna operating at large biogeographical scales.
Increasing influenza vaccination coverage in healthcare workers: analysis of an intensified on-site vaccination campaign during the COVID-19 pandemic
Authors: Schumacher Sofie , Salmanton-García Jon , Liekweg Andrea , Rolfes Muriel , Seidel Danila , Mellinghoff Sibylle C. , Cornely Oliver A. 
Published: March 2023

Abstract
Purpose
Influenza infections have substantial impact on healthcare institutions. While vaccination is the most effective preventive measure against influenza infection, vaccination coverage in healthcare workers is low. The study investigates the impact of an intensified influenza vaccination campaign in a maximum-care hospital on influenza vaccination coverage in healthcare workers during the COVID-19 pandemic in 2020/21.

Methods
Building on findings from our previously published review Schumacher et al. (Infection 49(3): 387, 2021), an intensified influenza vaccination campaign comprising a mobile vaccination team providing on-site vaccination and vaccination at a recurring central vaccination site in addition to promotional measures was performed and analysed regarding vaccination coverage. A survey querying vaccination motivation was performed. Campaign strategies and vaccination coverage of influenza seasons between 2017/18 and 2019/20 were analysed.

Results
The influenza vaccination campaign 2020/21 led to a significant 2.4-fold increase yielding an overall vaccination coverage of 40% among healthcare workers. A significant increase in vaccination coverage was observed across all professional fields; especially among nurses, a 2.7-fold increase, reaching a vaccination coverage of 48%, was observed. The COVID-19 pandemic positively influenced vaccination decision in 72% of first time ever or first time in over ten years influenza vaccinees. Vaccination coverage during prior vaccination campaigns focusing on educational measures did not exceed 17%.

Conclusion
A mobile vaccination team providing on-site vaccination and vaccinations at a central vaccination site in addition to promotional measures can be implemented to increase influenza vaccination coverage in healthcare workers. Our concept can inform influenza and other vaccination campaigns for healthcare workers.
Variability in Running Economy of Kenyan World-Class and European Amateur Male Runners with Advanced Footwear Running Technology: Experimental and Meta-analysis Results
Authors: Knopp Melanie , Muñiz-Pardos Borja , Wackerhage Henning , Schönfelder Martin , Guppy Fergus , Pitsiladis Yannis , Ruiz Daniel 
Published: March 2023

Abstract
Background
Advanced footwear technology improves average running economy compared with racing flats in sub-elite athletes. However, not all athletes benefit as performance changes vary from a 10% drawback to a 14% improvement. The main beneficiaries from such technologies, world-class athletes, have only been analyzed using race times.

Objective
The aim of this study was to measure running economy on a laboratory treadmill in advanced footwear technology compared to a traditional racing flat in world-class Kenyan (mean half-marathon time: 59:30 min:s) versus European amateur runners.

Methods
Seven world-class Kenyan and seven amateur European male runners completed a maximal oxygen uptake assessment and submaximal steady-state running economy trials in three different models of advanced footwear technology and a racing flat. To confirm our results and better understand the overall effect of new technology in running shoes, we conducted a systematic search and meta-analysis.

Results
Laboratory results revealed large variability in both world-class Kenyan road runners, which ranged from a 11.3% drawback to a 11.4% benefit, and amateur Europeans, which ranged from a 9.7% benefit to a 1.1% drawback in running economy of advanced footwear technology compared to a flat. The post-hoc meta-analysis revealed an overall significant medium benefit of advanced footwear technology on running economy compared with traditional flats.

Conclusions
Variability of advanced footwear technology performance appears in both world-class and amateur runners, suggesting further testing should examine such variability to ensure validity of results and explain the cause as a more personalized approach to shoe selection might be necessary for optimal benefit.
Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials
Authors: Wood Gina , Taylor Emily , Ng Vanessa , Murrell Anna , Patil Aditya , van der Touw Tom , Wolden Mitch , Andronicos Nick , Smart Neil A. 
Published: March 2023

Abstract
Background
Aerobic exercise training (AET) prescribed as lipid management treatment positively affects the standard lipid profile and reduces cardiovascular disease (CVD) risk. Apolipoproteins, lipid and apolipoprotein ratios, and lipoprotein sub-fractions may more effectively predict CVD risk than the standard lipid profile but an AET response in these biomarkers has not been established.

Objectives
We conducted a quantitative systematic review of randomised controlled trials (RCTs) to (1) determine the effects of AET on lipoprotein sub-fractions, apolipoproteins and relevant ratios; and (2) identify study or intervention covariates associated with change in these biomarkers.

Methods
We searched PubMed, EMBASE, all Web of Science and EBSCO health and medical online databases from inception to 31 December 2021. We included published RCTs of adult humans with ≥ 10 per group of participants; an AET intervention duration ≥ 12 weeks of at least moderate intensity (> 40% maximum oxygen consumption); and reporting pre/post measurements. Non-sedentary subjects, or those with chronic disease other than Metabolic Syndrome factors, or pregnant/lactating, as well as trials testing diet/medications, or resistance/isometric/unconventional training interventions, were excluded.

Results
Fifty-seven RCTs totalling 3194 participants were analysed. Multivariate meta-analysis showed AET significantly raised antiatherogenic apolipoproteins and lipoprotein sub-fractions (mmol/L mean difference (MD) 0.047 (95% confidence interval (CI) 0.011, 0.082), P = .01); lowered atherogenic apoliproteins and lipoprotein sub-fractions (mmol/L MD − 0.08 (95% CI − 0.161, 0.0003), P = .05); and improved atherogenic lipid ratios (MD − 0.201 (95% CI − 0.291, − 0.111), P < .0001). Multivariate meta-regression showed intervention variables contributed to change in lipid, sub-fraction, and apoliprotein ratios.

Conclusion
Aerobic exercise training positively impacts atherogenic lipid and apolipoprotein ratios, alipoproteins, and lipoprotein sub-fractions; and antiatherogenic apolipoproteins and lipoprotein sub-fractions. Cardiovascular disease risk predicted by these biomarkers may be lowered when AET is prescribed as treatment or prevention.

PROSPERO ID
CRD42020151925.
Marcatori prognostici nelle neoplasie neuroendocrine (NEN)
Authors: Zatelli Maria Chiara , Gagliardi Irene , Bondanelli Marta , Ambrosio Maria Rosaria 
Published: March 2023

SommarioL’incidenza delle neoplasie neuroendocrine (NEN) sta incrementando significativamente, mentre la sopravvivenza dei pazienti non migliora con la stessa velocità, a causa di diagnosi tardive e della mancanza di criteri prognostici consolidati in base ai quali pianificare la gestione del paziente. Se in molti casi i pazienti affetti da NEN hanno una prognosi molto buona e necessitano di un follow-up post-chirurgico di tipo conservativo, in alcuni casi è necessario mettere in campo terapie aggressive e strategie terapeutiche innovative per cercare di garantire al paziente la migliore sopravvivenza. Molte caratteristiche tumorali (sede, dimensioni, indici proliferativi, attività ormonale, captazione di radiotraccianti) sono attualmente utilizzate per valutare la sopravvivenza dei pazienti con NEN, ma la loro accuratezza è ancora limitata. In questa rassegna vengono illustrati nuovi possibili marcatori prognostici, sia di tipo clinico che di laboratorio, che potrebbero nel prossimo futuro migliorare la valutazione dei pazienti con NEN, risparmiando i pazienti affetti da forme indolenti da strategie terapeutiche molto aggressive che andranno, al contrario, offerte da subito a pazienti con forme più aggressive. Questo approccio può consentire di risparmiare risorse sanitarie e, soprattutto, dare migliori risposte ai bisogni del paziente.
Recent Advances of Transition Metal Basic Salts for Electrocatalytic Oxygen Evolution Reaction and Overall Water Electrolysis
Authors: Guo Bingrong , Ding Yani , Huo Haohao , Wen Xinxin , Ren Xiaoqian , Xu Ping , Li Siwei 
Published: March 2023

AbstractElectrocatalytic oxygen evolution reaction (OER) has been recognized as the bottleneck of overall water splitting, which is a promising approach for sustainable production of H2. Transition metal (TM) hydroxides are the most conventional and classical non-noble metal-based electrocatalysts for OER, while TM basic salts [M2+(OH)2-x(Am−)x/m, A = CO32−, NO3−, F−, Cl−] consisting of OH− and another anion have drawn extensive research interest due to its higher catalytic activity in the past decade. In this review, we summarize the recent advances of TM basic salts and their application in OER and further overall water splitting. We categorize TM basic salt-based OER pre-catalysts into four types (CO32−, NO3−, F−, Cl−) according to the anion, which is a key factor for their outstanding performance towards OER. We highlight experimental and theoretical methods for understanding the structure evolution during OER and the effect of anion on catalytic performance. To develop bifunctional TM basic salts as catalyst for the practical electrolysis application, we also review the present strategies for enhancing its hydrogen evolution reaction activity and thereby improving its overall water splitting performance. Finally, we conclude this review with a summary and perspective about the remaining challenges and future opportunities of TM basic salts as catalysts for water electrolysis.
Leben und Sterben des »Geistes«
Authors: Neuffer Moritz 
Published: March 2023

ZusammenfassungDer Aufsatz fragt nach dem Beitrag einer kulturgeschichtlich orientierten Zeitschriftenforschung zu Historiografien des Wissens, der Künste und der Theorie. Zu den spezifischen Dynamiken des Mediums, so die These, gehören nicht zuletzt Konzeptionen und (Selbst‑)Imaginationen von Zeitschriften als Verkörperungen des »Geistes« in der Zeit.
Benefit for non-operative treatment of pediatric appendicitis with intra-abdominal abscess. A single-center report
Authors: Ghidini Filippo , Donà Daniele , Giacomini Edoardo , De Corti Federica , Tognon Costanza , Zuliani Monica , Gamba Piergiorgio , Virgone Calogero 
Published: March 2023

Abstract
Purpose
Non-operative treatment (NOT) for pediatric acute appendicitis complicated with intra-abdominal abscess (IAA) has been introduced in the last decade. The study aimed to report our experience with this approach and investigate potential predictors of success.

Methods
Medical records of patients affected by appendicitis complicated with IAA between January 2013 and December 2020 were reviewed. The interval before delayed appendectomy, rate of re-admission before delayed appendectomy and the rate of delayed appendectomy were the endpoints of NOT. The outcomes were compared between patients treated by NOT and patients who underwent urgent surgery for complicated appendicitis.

Results
In the study period, twenty-six patients (37%) underwent NOT, and 45 (63%) underwent urgent surgery for complicated appendicitis with IAA. A delayed appendectomy was performed in 24 children (92%). The median time before surgery was 32 days (IQR 20–58 days). Eight children (31%) were re-admitted before delayed appendectomy, and three cases presented a disease relapse. An appendicolith was detected in two of them.
Even though the overall hospital stay was longer for NOT (p = 0.0009), all these patients underwent laparoscopic appendectomy, and no conversions were reported (p = 0.0001; p = 0.0006). In addition, no difference in the rate of post-operative complications was found between the two groups (p = 0.62).

Conclusions
NOT presented a high rate of success. The presence of appendicolith at diagnosis might be considered a negative predictor of success. NOT might increase the success of mini-invasive surgery when compared to urgent surgery.