bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Grade Gliomas and Cancer Predisposition Syndromes in children and adolescents: Unpacking the Impact through a Single-Center Analysis
Authors: Mastronuzzi Angela , Baldo Giada Del , Montante Claudio , Cipri Selene , Boccuto Luigi , Agolini Emanuele , Novelli Antonio , Cacchione Antonella , Lodi Mariachiara , Ioris Maria Antonietta , Cortellessa Fabiana , Macchiaiolo Marina , Barresi Sabina , Giovannoni Isabella , Rossi Sabrina , Miele Evelina , Vinci Maria , Carai Andrea , Locatelli Franco 
Published: August 2023

Abstract
The correlation of pediatric high-grade gliomas with cancer predisposition syndromes (CPS) is poorly defined in the literature and next generation sequencing (NGS) is increasingly being used in support of diagnosis. We retrospectively analyzed NGS data from 77 consecutive children diagnosed with different types of pediatric high-grade glial tumors to identify the presence of germline variants predisposing to cancer. Sixty-four germline variants were detected in 44 cases (57.1%). Among all 64 variants, there were 6 (9.4%) pathogenic (P) variants, 8 (12.5%) likely pathogenic (LP), 40 (62.5%) variants of uncertain significance (VUS) and 10 (15.6%) likely benign and benign (LB/B). Finally, P/LP variants in CPS genes related were found in 13 children (16.9%). The distribution of variants was not significantly different in subgroups; however, the highest rate of P (80%) was observed in diffuse midline gliomas (DMG). Globally, P/LP were associated with lower overall-survival (59.2%) compared to VUS (74.1%) and no germline mutation/LB/B (80.9%). Our data represent the largest available NGS investigation in children with high-grade gliomas and suggest a potential prognostic disadvantage of P/LP compared to VUS and no mutation/LB.
A Quantum Beta Distributed Multi-Objective Particle Swarm Optimization Algorithm for Twitter Fake Accounts Detection
Authors: Aboud Ahlem , Rokbani Nizar , Mirjalili Seyedali , Hussain Amir , Chabchoub Habib , Alimi Adel M. 
Published: August 2023

Abstract
Fake account detection is a topical issue when many Online Social Networks encounter several issues caused by the growing number of unethical online activities. This study presents a new Quantum Beta-behaved Multi-Objective Particle Swarm Optimization (QB-MOPSO) algorithm for machine learning based Twitter fake accounts detection. The proposed approach aims to improve the learning process of deep neural networks, random forest, through minimizing simultaneously the feature dimensionality and the classification error rate. The main contribution consists in proposing a quantum beta MOPSO to handle the training phase of neural and deep architectures. The QB-MOPSO is used to perform a multi-objective training of the random forest algorithm. The QB-MOPSO has two optimization profiles: the first one uses a quantum-behaved equation for improving the exploratory behaviour of PSO, while the second one uses a beta function to enhance PSO’s exploitation. An extensive experimental study is carried out using two open Twitter datasets with 1982 and 928 accounts. The new proposal is a random forest QB-MOPSO. Results showed that random forest QB-MOPSO accuracy is about 99.19% and 97.52% accounts on datasets 1 and 2. Comparative analysis of the prosed architecture toward the original architecture showed that the use of QB-MOPSO for learning enhances the random forest algorithm which perform then the original ones.
Temporal dynamics of plant-soil feedback and related mechanisms depend on environmental context during invasion processes of a subtropical invader
Authors: Li Yangping , Li Wei-Tao , Li Ju , Feng Yu-Long 
Published: August 2023

Abstract
Aims Plant-soil feedback (PSF), which may vary across spaces and time, is considered as an important mechanism in biological invasions. However, it is still unclear how PSF changes during biological invasions in different environments.
Methods To address this problems, we measured aboveground biomass and cover of the invasive plant Ageratina adenophora, richness and diversity of its co-occurring natives, PSFs for the invader, soil nutrients and fungal communities at uninvaded, recently and long invaded sites in lightly and severely disturbed habitats.
Results Invasion time and habitats influenced PSFs for the invader interactively. With increasing invasion time, the PSFs (trend) decreased significantly, while dominance of the invader and its ecological impacts remained similar in the lightly disturbed habitats; in the severely disturbed habitats, however, the PSFs, the invader’s dominance and impacts all increased. The PSFs were higher, especially at long invaded sites, in the severely (positive) relative to the lightly (neutral or negative) disturbed habitats, contributing to the observed patterns of the invader’s dominance and impacts. The dynamics of the PSFs were associated with soil nutrients and microbes, and the former may function indirectly via affecting the lattes. Soil pathogens and AMF contributed to the dynamics of the PSFs in some cases, but not in others.
Conclusions These findings indicate that the complex spatiotemporal dynamics of PSFs may contribute to the dynamics of dominance and impact of invasive species in forests, and highlight the need to consider the effects of invasion time and environments when studying PSFs.
An Improved Algorithm for Multi-Clusters TSP Based on ACO
Authors: Lin Jianbing , She Yuping 
Published: August 2023

Abstract
In order to improve the efficiency of ACO algorithm in solving TSP problems with multi-cluster features, concepts of domain and density are defined. Then an improved ACO algorithm named MC-ACO is proposed for TSP with multi-cluster feature. The basic principles and Strategies of MC-ACO algorithm are introduced. The releasing mechanism of pheromone is analyzed, and probability of the next node selection in the final domain is processed to distinguish the different behaviors of ants inside and outside the clusters. The progress of the MC-ACO algorithm involving the jump process between clusters is illustrated in detail. Finally, this work makes some simulation experiments for TSP with MC-ACO and ACS, the test results show that MC-ACO has obvious advantages over ACS algorithm in solving TSP problems which have multiple clusters and large scale of nodes.
A cohort study on the effects of Baitouweng decoction combined with drugs and endoscopy on clinical symptoms, immune level, and long- term prognosis in patients with ulcerative colitis
Authors: Yuan Wenjun , Mao Yingming , Wang Lina , Xie Huiping 
Published: August 2023

Abstract
Objective
A case-control study was carried out to research the effects of Baitouweng decoction combined with drugs and endoscopy on clinical symptoms, immune level, and long-term prognosis of patients with ulcerative colitis (UC).
Methods
From March 2019 to March 2022, 100 patients with UC cured were arbitrarily divided into control and study groups in our hospital. The former group was cured with general treatment according to diagnosis and treatment and Mesalamine Rectal Enema at the same time. The effective rate was calculated. The syndrome scores, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM) levels, enteroscopy score, and colon pathology score were compared before and after treatment.
Results
There was a 96.00% resultful rate in the study group, while the resultful rate in the control group was 76.00%. The study group achieved a higher resultful rate (P < 0.05). After 3 months of treatment, the total score of abdominal pain, diarrhea, abdominal distension, acute weight, purulent and bloody stool, fatigue, addiction, and TCM syndrome decreased noticeably. The research group's TCM syndrome scores were considerably lower (P < 0.05). The score of colonoscopy and colon pathology in the study group was lower (P < 0.05). And the levels of IgA, IgM, and IgG in the study group were lower (P < 0.05). In the control group, intestinal obstruction occurred in 4 cases, rectal canceration in 6 cases, and colonic polyp in 2 cases. The total incidence of complications was 24.00%. There was 1 case of intestinal obstruction, 2 cases of rectal canceration, and 1 case of colonic polyp with a total of 8.00% complications. Complication rates in the study group were noticeably lower (P < 0.05).
Conclusion
Baitouweng decoction combined with medicine and endoscopy has a noticeable clinical effect on patients with UC, which can not only effectively enhance the clinical symptoms and intestinal mucosa and histopathology of patients with UC, but also noticeably strengthen the recovery of immune function of patients with UC.
Relationship between food group-specific intake and depression among local government employees in Japan
Authors: Kitabayashi Makiko , Umetsu Shoko , Suzuki Miho , Konta Tsuneo 
Published: August 2023

Abstract
Background: We aimed to examine the relationship between food group-specific intake and depression among workers in Japan.
Methods: A questionnaire survey was administered to 568 workers in 2020, 503 workers responded, and 423 workers were included in the analysis. Information on sex, age, body mass index, overtime hours, sleep duration, marital status, employment position, exercise habits, smoking status, incidence of depression, and intake of energy, proteins, lipids, carbohydrates, alcohol, and specific food groups were collected. The Center for Epidemiologic Studies Depression Scale was used to assess the presence and severity of depression. Food group-specific intake was adjusted for energy intake using the residual method and classified into low, moderate, and high by sex. Logistic regression was used to examine the odds ratios (ORs) and trends according to sex, with the presence/absence of depression as the dependent variable and food group-specific intake as the independent variable.
Results: Men in the eggs low-intake and dairy moderate-intake groups, and women in the other vegetables low- and moderate-intake, total vegetables low-intake, eggs moderate-intake, and sweets moderate-intake groups had significantly higher adjusted ORs (aORs) for depression. The aOR for depression was significantly higher in men and women with low intake of eggs, and in women alone with low intake of other vegetables and total vegetables. Another dose-response relationship was observed, with a significantly lower aOR for depression in men with low intake of sweets.
Conclusion: The intake of eggs and sweets in men and eggs and vegetables in women may be related to depression.
Fluctuation mediated spin-orbit torque enhancement in the noncollinear antiferromagnet Mn3Ni0.35Cu0.65N
Authors: Kläui Mathias , Bose Arnab , Shahee Aga , Saunderson Tom , Hajiri Tetsuya , Rajan Adithya , Go Dongwook , Schwingenschlögl Udo , Manchon Aurelien , Mokrousov Yuriy , Asano Hidefumi 
Published: August 2023

Abstract
The role of spin fluctuations near magnetic phase transitions is crucial for generating various exotic phenomena, including anomalies in the extraordinary Hall effect, excess spin-current generation through the spin-Hall effect (SHE), and enhanced spin-pumping, amongst others. In this study, we experimentally
investigate the temperature dependence of spin-orbit torques (SOTs) generated by Mn3Ni0.35Cu0.65N (MNCN), a member of the noncollinear antiferromagnetic family that exhibits unconventional magnetotransport properties. Our work uncovers a strong and nontrivial temperature dependence of SOTs, peaking near the Néel temperature of MNCN, which cannot be explained by conventional intrinsic and extrinsic scattering mechanisms of the SHE. Notably, we measure a maximum SOT efficiency of 30%, which is substantially larger than that of commonly studied nonmagnetic materials such as Pt. Theoretical calculations confirm a negligible SHE and a strong orbital Hall effect which can explain the observed SOTs. We propose a previously unidentified mechanism wherein fluctuating antiferromagneticmoments trigger the generation of substantial
orbital currents near the Néel temperature. Our findings present an approach for enhancing SOTs, which holds promise for magnetic memory applications by leveraging antiferromagnetic spin fluctuations to amplify both orbital and spin currents.
Development of Mg/CaSiO3-MgO Composites Using Metallurgic Slag by Powder Metallurgy
Authors: Villarreal-Fuentes Brandon Osvaldo , Reyes Mario Rodríguez , Vázquez-Obregón Dagoberto , Matamoros-Veloza Zully , Pérez-Terrazas Jaime Enrique , Romero Gerardo Daniel Olvera , Mancha-Molinar Héctor 
Published: August 2023

Abstract
The mechanical properties of ceramic reinforced metal matrix composites make them highly attractive for various industrial applications. In this study, magnesium/metallurgic slag (Mg/MS) composites were fabricated using the powder metallurgy (PM) technique with varying MS content up to 15%, followed by sintering at 723K (450°C) for one hour. XRD analysis revealed the presence of magnesium, periclase and pseudowollastonite phases in the composites. Results of Vickers hardness and compressive strength tests showed that the maximum values were achieved in the composites containing 15% MS, with values of 93 HV and 382 MPa, respectively. Generally, as the MS content increased, the density of the composites also increased. The fracture surfaces of the experimental composites displayed cleavage, indicating brittle fracture.
Aneuploidy in facultative parthenogenetic Drosophila
Authors: Sperling Alexis , Glover David M. 
Published: August 2023

Abstract
From concatenated chromosomes to polyploidization, large-scale genome changes are known to occur in parthenogenetic animals. Here, we report mosaic aneuploidy in brains of facultatively parthenogenetic Drosophila. We identified a background of aneuploidy in D. mercatorum strains and found increased levels of aneuploidy in the brain tissue of animals arising parthenogenetically versus those arising from sexual reproduction. There is also variation in germline-derived aneuploidy between individuals within the strain. To determine if this is a general feature of facultative parthenogenesis in drosophilids, we compared sexually reproduced and parthenogenetic offspring from an engineered facultative parthenogenetic strain of D. melanogaster. In addition to germline-derived aneuploidy, this revealed somatic aneuploidy that increased by up to 4-fold in parthenogens compared to sexually reproduced offspring. Therefore, the genetic combination identified in D. mercatorum to cause facultative parthenogenesis in D. melanogaster results in aneuploidy, which indicates that the loss of mitotic control resulting in parthenogenesis causes subsequence genome variation within the parthenogenetic offspring. Our findings challenge the assumption that parthenogenetic offspring are near genetic replicas of their mothers.
Clinical implications of AR alterations in advanced prostate cancer: A multi-institutional collaboration
Authors: Dorff Tanya , Zengin Zeynep , Henderson Nicholas , Park Joseph , Ali Alicia , Nguyen Charles , Hwang Clara , Barata Pedro C. , Bilen Mehmet , graham laura , Mo George , Kilari Deepak , Tripathi Abhishek , Labriola Matthew , Rothstein Shoshana , Garje Rohan , Koshkin Vadim , Patel Vaibhav , Schweizer Michael , Armstrong Andrew , McKay Rana , Alva Ajjai 
Published: August 2023

Abstract
Background: AR gene alterations can develop in response to pressure of testosterone suppression and androgen receptor targeting agents (ARTA). Despite this, the relevance of these gene alterations in the context of ARTA treatment and clinical outcomes remains unclear.
Methods: Patients with castration-resistant prostate cancer (CRPC) who had undergone genomic testing and received ARTA treatment were identified in the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort (PROMISE) database. Patients were stratified according to the timing of genomic testing relative to the first ARTA treatment (pre-/post-ARTA). Clinical outcomes such as time to progression, PSA response, and overall survival were compared based on alteration types.
Results: In total, 540 CRPC patients who received ARTA and had tissue-based (n=321) and/or blood-based (n=244) genomic sequencing were identified. Median age was 62 years (range 39-90) at the time of the diagnosis. Majority were White (72.2%) and had metastatic disease (92.6%) at the time of the first ARTA treatment. Pre-ARTA genomic testing was available in 24.8% of the patients, and AR mutations and amplifications were observed in 8.2% and 13.1% of the patients, respectively. Further, time to progression was longer in patients with AR amplifications (25.7 months) compared to those without an AR alteration (9.6 months; p=0.03). In the post-ARTA group (n=406), AR mutations and AR amplifications were observed in 18.5% and 35.7% of the patients, respectively. The most common mutation in post-ARTA group was L702H (9.9%).
Conclusion: To our knowledge, this is the largest real-world clinicogenomics database-driven study exploring the development of ARalterations and their association with ARTA treatment outcomes. Our study showed that AR amplifications are associated with longer time to progression on first ARTA treatment. Further prospective studies are needed to optimize therapeutic strategies for patients with AR alterations.
Overcoming the leptomeningeal seeding of medulloblastoma by targeting HSP70
Authors: Choi Seung Ah , Ha Saehim , Kim Seung-Ki , Hwang Do Won , Youn Hyewon , Heng Sokhoeun , Phi Ji Hoon 
Published: August 2023

Abstract
Purpose The development of leptomeningeal seeding (LMS) through the cerebrospinal fluid (CSF) is common in medulloblastoma (MB) and a major cause of treatment failure. The mechanism of MB LMS remains unclear, and effective treatment options are urgently required. This study aimed to discover molecules that can specifically target seeding cells by making a cellular model of MB LMS and analyzing their specific genetic and functional characteristics.Methods Through repeated transplantation, separation, culture, and characterization, seeding and non-seeding MB cells were isolated. A comprehensive analysis of the cellular characteristics was conducted, and differentially expressed genes (DEGs) were identified through gene expression profiling. In vitro and in vivo experiments were performed to evaluate the therapeutic effects of selected inhibitors targeting a specific protein.Results We successfully isolated seeding and non-seeding cells through a three-step process. Analysis of DEGs revealed heat shock protein 70 (HSP70) as the most highly expressed gene in the seeding cells, with metabolic pathways being prominently enriched. While seeding cells (S3) exhibited slower proliferation than non-seeding cells (N3), there was no significant difference in viability. Notably, S3 showed delayed wound-healing but increased collagen adhesion ability. HSP70 suppression experiments demonstrated that VER155008, among the six inhibitors tested, efficiently targeted S3 cells and inhibited the expression of multidrug resistance-associated protein (MRP) proteins. Importantly, in vivo treatment with VER155008 resulted in reduced LMS along the spinal cord. Furthermore, a synergistic effect was observed when VER155008 was combined with 4-hydroperoxycyclophosphamide.Conclusion Our findings suggest that targeting HSP70 holds promise as a potential treatment option to suppress LMS in MB.
Optimization of Hot-wire Fraction for Enhance Quality in GMAW
Authors: Suwannatee Nattasak , Yamamoto Motomichi , Shinohara Shinichiro 
Published: August 2023

Abstract

The combination of hot-wire insertion technology and gas metal arc welding (GMAW) is proposed to increase deposition rate and reduce power consumption. This study systematically investigated the effect of hot-wire fraction on weld metal properties. The results show that the compensatory deposition rate from hot-wire insertion provides a similar effective height compared with the rate from conventional GMAW, with a lower weld height/width ratio, lower power consumption, and improved mechanical properties. However, an excessive hot-wire fraction can lead to lack of fusion, and this value should be limited to no more than 44% of the total deposition rate. The relative GMAW and hot-wire fractions were optimized to maximize total deposition volume while avoiding lack of fusion and providing sufficient penetration. With the optimized condition, hot-wire GMAW could be efficiently used to obtain similar deposition rates with lower power consumption and without sacrificing toughness properties. This proposed process offers a sustainable alternative development to conventional GMAW.
Sustainable Development Pathways for Energies in Yangtze River Delta Urban Agglomeration
Authors: Xie Da , Xu Chao , Gu Chenghong , Zhao Pengfei , Wang Xitian , Wang Yanjia 
Published: August 2023

Abstract
Urban agglomerations consume energy from various sectors，such as transportation sector, industry sector, and building sector. Meanwhile, the exchange and optimization of energy consumption in these sectors contributes to the sustainable development of urban agglomeration energy systems. However, the overall impact of the cross-sector energy optimization and complementarity has not been quantitatively analyzed. Here, we focused on the Yangtze River Delta (YRD) urban agglomeration in China and proposed an optimization framework for energy, environment, and economy. The framework considered four perspectives: transportation sector, power sector, industry sector, and building sector, in order to determine the most sustainable development path for the urban agglomeration. We found that this strategy resulted in a 53.1 billion tons increase in CO2 emissions reduction in the region. The results of emission reduction varied across sectors, ranging from 4.5 to 22.2 billion tons CO2 equivalent, and across cities, ranging from 7.1 to 4688.1 Mt. The results suggest that the core cities in the urban agglomeration can take on a leadership role. By promoting cross-sector collaboration and implementing energy recycling, the energy efficiency of surrounding cities can be greatly improved, leading to the sustainable development of the urban agglomeration.
Effect of an Educational Guideline on Nurses' Performance Caring for critically ill Patients with Digital Chest drainage system
Authors: Mahmoud Sara Fathy , Mourad Amira Hedaya , Senosy Ayman Muhammad Kamel 
Published: August 2023

Abstract
Background Caring for critically ill patients with chest drain is an essential part of nursing practice, especially for those nurses who care for patients with complicated respiratory problems or undergo cardiothoracic surgery.Aim This study aims to assess the effect of an educational guideline on nurses' performance caring for critically ill patients with digital chest drainage system.Methods A quasi experimental design was utilized. At cardiac intensive care unit & chest intensive care unit which affiliated to Ain Shams University Hospital at Cairo - Egypt. A purposive sample of 50 nurses caring for patients with digital chest drainage system in the previously mentioned units were be recruited in the current study. Two tools were used to collect data related to achieve the aim of the present study as following I-Nurses’ knowledge self-administered questionnaire and II-nurses' practice observational checklist.Results Most of nurses had total unsatisfactory level of performance regarding caring for critically ill patients with digital chest drainage system pre the educational guideline implementation. Meanwhile the majority of the study sample had statistically significant improvement in their performance post the educational guideline implementation. While this improvement lowered slightly post 3 months at follow up.Conclusion The educational guideline for nurses was effective in improving their performance regarding caring for critically ill patients with digital chest drainage system. Recommendations: Conducting periodic in-service training advanced care programs for nurses help in improving their performance and quality of care that provided to critically ill patients with digital chest drainage system.