bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protean career orientation and job search: investigating the mediating role of career optimism in mentoring relationships
Authors: Gong Zhenxing , Gilal Faheem Gul , Gilal Rukhsana Gul , Jahanzeb Agha 
Published: March 2023

Purpose
Protean career orientation is a key element that helps explain why workers plan and manage their careers. In the field of nursing, a protean career orientation assists nurses in job search, career mobility and adapting to changing demands. Few studies have explored how nurses’ protean career orientation will lead to job search and how to make better use of the protean career orientation. This study aims to explore how a protean career orientation influences job search via career optimism and the moderating role of mentoring relationships.

Design/methodology/approach
This study conducted a cross-sectional survey of 309 frontline nurses from China. The questionnaire was distributed to nurses through the snowball sampling method. Jamovi 1.2.2 was used for descriptive analysis and Pearson’s correlation analysis. The relationships between the variables and their significance were tested using Process Macro 3.3.

Findings
Results show that protean career orientation was significantly related to career optimism and positively related to job search. Career optimism was significantly related to job search. The indirect effect of protean career orientation on job search through career optimism was significant. The interaction between protean career orientation and mentoring relationships was also significantly related to career optimism.

Originality/value
To the best of the authors’ knowledge, this study is the first to demonstrate how nurses’ flexible career orientation significantly impacted job search through nurses’ career optimism. If nurses work in supportive mentoring relationships, the positive effect of the nurse’s protean career orientation on the job search is decreased.
Assessing the impact of wealth inequality on state capture in Latin America
Authors: Korman James Guy 
Published: March 2023

Purpose
This study aims to analyze the effects of economic inequalities on state capture in Latin America. Economic inequalities are the defining issues of our time. While the effect of economic inequality has been explored before on its impact on state capture in Latin America, it has often been done in a qualitative manner. Moreover, most quantitative research to date uses poor proxy variables to assess the impact of inequalities on corruption and or state capture, such as the Gini coefficient, which suffers from a lot of missing data.

Design/methodology/approach
A random effects regression model is used to enable the exploitation of between level variation to greater generalize the results across the Latin American region while minimizing bias to the coefficient estimates.

Findings
The results demonstrate that the top 1% wealth inequality is highly statistically significant and positive in explaining the variation in state capture. The greater the share of wealth the 1% hold, the more state capture we should expect.

Originality/value
To the best of the authors’ knowledge, this paper presents the first empirical study using a novel variable, the top 1% share wealth inequality derived from the World Inequality Database that directly measures the top 1%’s share of wealth overall. The study examines the empirical effect of the top 1%’s share of wealth inequality in contributing to state capture. Nineteen Latin American countries are analyzed across the temporal period 1996–2021.
Innovation capabilities and export performance of SMEs: does managers' risk-taking propensity matter?
Authors: Ringo Denis Samwel , Tegambwage Amani Gration , Kazungu Isaac 
Published: March 2023

PurposeThis paper aims to examine the relationship between innovation capabilities (INVC) and export performance (EXPERF) of manufacturing small and medium enterprises (SMEs). Moreover, the paper aims to investigate the moderating effect of risk-taking propensity (RSTP) in the relationship between INVC and the SMEs’ EXPERF.Design/methodology/approachA cross-sectional survey design was used and data were collected through structured questionnaires from 250 manufacturing exporting SMEs in Tanzania. Confirmatory factor analysis was used to test the measurement model. The hypotheses were empirically tested using PROCESS macro test.FindingsThe findings affirm that INVC is a significant predictor of EXPERF. Additionally, RSTP was found to be a significant moderator of the relationship between INVC and EXPERF.Research limitations/implicationsAlthough the study was able to accomplish its overall objective, it is limited in terms of the context under which the study was conducted. This study covered only manufacturing SMEs in a single country, Tanzania. Hence, the findings should be interpreted with caution since each country has specific institutional environments that support innovation.Originality/valueThe findings of this study expand the application of the resource-based view (RBV) theory in exporting context. The study revealed how INVC as an intangible resource can lead to successful performance. Hence, the findings of this study broaden the applicability of RBV theory. Also, this study contributes to the debate about the innovation-export performance relationship by revealing a moderating role of RSTP in the relationship between INVC and EXPERF.
Influence and behaviour of the new standard setters in the sustainability reporting arena: implications for the Global Reporting Initiative’s current position
Authors: Afolabi Hammed , Ram Ronita , Rimmel Gunnar 
Published: March 2023

Purpose
This study aims to examine the influence and behaviour of the European Financial Reporting Advisory Group (EFRAG)/European Commission, and the International Financial Reporting Standards (IFRS) Foundation/International Sustainability Standards Board in the standardisation of sustainability reporting arena and their implications for the Global Reporting Initiative’s (GRI) current position.

Design/methodology/approach
This paper draws on the arena concept, particularly the work of Renn (1992) and Georgakopoulous and Thomson (2008), to explore the EFRAG and the IFRS Foundation’s behaviour towards the standardisation of the sustainability reporting arena and their implications for the GRI’s current position. Further, the documents and public releases pertinent to the activities and output of the GRI, the EFRAG/European Commission and the IFRS Foundation are used. The documents are screened and analysed based on the key elements of arena concept that emerged, which includes “agenda, claims, network of bodies and group engaged, interaction and behaviour with arena issues (audience, materiality, scope and core priorities, purpose of reporting and relevance to sustainable development)”.

Findings
This study reveals the source of motivation and influence of the new standard setters in the sustainability reporting arena and documents the relevance of their behaviour as an actionable strategy to change the arena rule. Particularly, this paper demonstrates the perceived fall away from driving business behaviour towards the pursuit of sustainable development if the GRI and its standards cease to exist.

Practical implications
The pathway to achieve sustainable development and improve sustainability impact disclosure remains a debatable issue among policymakers and users of sustainability reporting standards. This study reconstructs the awareness of different dynamics at play inhibiting the harmonisation of sustainability reporting standardisation and the importance of the GRI in pursuing global sustainable development.

Social implications
The pattern of behaviour and agenda of sustainability institutions and influential standard setters harnessed in this paper are aimed at enabling the existence of the rules that can uphold the primary focus of the sustainability reporting arena, particularly in achieving global sustainable development.

Originality/value
This paper furthers the understanding of the importance of the GRI in upholding the key tenets and traditional agenda of sustainability reporting and sustainable development.
Outcomes after inter‐hospital transfer of intensive care patients with haemorrhagic stroke: a 5‐year retrospective review
Authors: Kam Jeffrey K. P. , Dodds Jarron M. , Kam Jeremy K. T. , Dawes Bryden H. , Ghani Manisa 
Published: March 2023

AbstractBackgroundInter‐hospital transfer (IHT) of intensive care patients is a limited resource. We assessed the outcomes of patients with haemorrhagic stroke requiring IHT and intensive care and aimed to identify early prognostic factors of poor neurological outcome.MethodsWe conducted a retrospective observational cohort study of patients admitted to a single tertiary intensive care unit (ICU) with haemorrhagic stroke after IHT between January 2014 and December 2018. Primary outcome was poor neurological outcome (modified Rankin Scale ≥4 at time of discharge from hospital or rehabilitation unit). Secondary outcomes were mortality rate, rate of intervention, rate of organ donation surgery (ODS) and potentially avoidable transfer (PAT). PAT was defined as transfer where the patient did not receive an intervention and had a poor neurological outcome.ResultsNinety patients were included in this study, 48 with intracerebral haemorrhage (ICH) and 42 with subarachnoid haemorrhage (SAH). Fifty‐one (56.7%) patients had a poor neurological outcome, including 30 (33%) who died. Factors significantly associated with poor neurological outcome included age > 80 years, lower presenting Glasgow Coma Score (GCS) and bilaterally fixed and dilated pupils. Stepwise logistic regression demonstrated history of hypertension as significantly associated with poor neurological outcome in patients with ICH (P = 0.021). Seven (7.8%) patients had ODS. Sixty‐four (71.1%) patients received intervention and 20 (22.2%) transfers were potentially avoidable.ConclusionsPatients in this cohort are at high risk of poor neurological outcome. Prognostic factors identified in this study may help referring, retrieval and receiving clinicians to discuss futility prior to pursuing IHT.
Altered GABAA receptor function in women with endometriosis: a possible pain‐related mechanism
Authors: Sandström Anton , Bixo Marie , Bäckström Torbjörn , Möller Anna , Turkmen Sahruh 
Published: March 2023

AbstractIntroductionThe mechanism underlying endometriosis‐related pain remains poorly understood. Previous studies have indicated that γ‐aminobutyric acid (GABA) type A (GABAA) receptors and GABAergic substances (eg endogenous neurosteroids) play important mechanistic roles in various pain conditions. Our primary objective was to compare GABAA receptor function between women with endometriosis and healthy controls by performing a challenge test with diazepam, a GABAA receptor agonist, using the saccadic eye velocity as the main outcome. The secondary objective was to investigate the relation between GABAA receptor function and serum levels of allopregnanolone, an endogenous positive modulator of the GABAA receptor, in the participating women.Material and methods15 women with pelvic pain and laparoscopically confirmed endometriosis and 10 healthy, symptom‐free, control women, aged 18–40 years, underwent the diazepam challenge test during the follicular phase of the menstrual cycle. Basal serum allopregnanolone levels were measured prior to diazepam injection.ResultsCompared with healthy controls, women with pelvic pain and confirmed endometriosis had a significantly smaller change in saccadic eye velocity after GABAA receptor stimulation with diazepam, indicating lower sensitivity to diazepam. The saccadic eye velocity response was not correlated with the serum allopregnanolone levels.ConclusionsWomen with painful endometriosis show altered GABAA receptor function, depicted as a muted response to an exogenous GABAA receptor agonist.
Lymphomatoid papulosis with DUSP22–IRF4 rearrangement: A case report and literature review
Authors: Niu Na , Heberton Meghan M. , Tang Zhenya , Aung Phyu P. , Nagarajan Priyadharsini , Curry Jonathan L. , Prieto Victor G. , Torres‐Cabala Carlos A. , Cho Woo Cheal 
Published: March 2023

AbstractLymphomatoid papulosis (LyP) with DUSP22–IRF4 rearrangement is a rare, recently described variant of LyP histopathologically characterized by a biphasic growth pattern, with epidermotropic small‐to‐medium‐sized atypical T‐cells and dermal large and transformed T‐cells diffusely expressing CD30. LyP with DUSP22–IRF4 rearrangement can mimic other cutaneous lymphoproliferative disorders, particularly primary cutaneous anaplastic large cell lymphoma (PCALCL) or transformed mycosis fungoides (MF). Unlike PCALCL or transformed MF, LyP with DUSP22–IRF4 rearrangement shows an indolent clinical behavior, with frequent spontaneous regression of untreated lesions. Thus, it is important to recognize this rare variant of LyP to avoid misclassification, which may potentially lead to unnecessarily aggressive patient management. To our knowledge, only 13 cases of LyP with DUSP22–IRF4 rearrangement have been reported to date in the English literature. Herein, we describe an additional case of LyP with DUSP22–IRF4 rearrangement in a 63‐year‐old man and provide a comprehensive literature review with regards to the clinical, histopathologic, and molecular features of this novel entity.
Incidence, prognostic factors, and survival outcomes in patients with blastic plasmacytoid dendritic cell neoplasm: A retrospective study in the Surveillance, Epidemiology, and End Results database
Authors: Lin Xiaojing , Wang Li , Hu Qian , Zhu Jinbing , Tao Yali , Huang Li , Niu Ting 
Published: March 2023

AbstractThere are few large‐scale epidemiological and prognostic studies on blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its rarity. We used the Surveillance, Epidemiology, and End Results database to investigate the incidence, clinical characteristics, prognostic factors, and survival trends of BPDCN. The age‐adjusted incidence of BPDCN had a bimodal pattern with peaks in those under 20 and 60 years and older. Of 697 patients, the median age at diagnosis was 31 years. The most common primary sites were lymph nodes (59.4%), followed by bone marrow (17.1%) and skin (11.6%). Extranodal involvement (59.7%) was more common in patients aged 60 years and older, while lymph node involvement was predominant in other age groups. The 1‐year, 3‐year, and 5‐year overall survival (OS) rates were 90.7%, 83.7%, and 82.3% in patients aged under 20, but dropped to 53.1%, 27.7%, and 20.0% in patients aged 60 and older. Multivariate Cox regression analysis revealed that age, sex, and first malignancy were independent prognostic factors for OS. Based on this regression model, a nomogram was built with high discrimination and calibration. The incidence, clinical characteristics, and prognosis of BPDCN patients vary by age group. Moreover, using the nomogram to predict OS can help guide individualized evaluations and clinical decisions.
A novel Reelin construct, R36, recovered behavioural deficits in the heterozygous reeler mouse
Authors: Morrill Nicole K. , Li Qingyou , Joly‐Amado Aurelie , Weeber Edwin J. , Nash Kevin R. 
Published: March 2023

AbstractReelin, a large extracellular glycoprotein, plays a critical role in prenatal brain development and postnatally in synaptic plasticity, learning and memory. Dysregulation of Reelin signalling has been implicated in several neuropsychiatric disorders including schizophrenia, autism, depression and Alzheimer's disease. Previous studies have demonstrated that Reelin's central fragment, R3456, binds to ApoER2, inducing ApoER2 clustering and subsequent intracellular signalling. We previously reported the development of a novel luciferase complementation assay, which we used to demonstrate that R3456 can lead to ApoER2 receptor dimerization. Using this same assay, we explored various smaller fragments and combinations from R3456, and we identified a construct of repeats 3 and 6 (R36), which could still elicit equivalent receptor dimerization. The purpose of this study was to test R36 for biological effects in vitro and in vivo. We show that R36 was capable of initiating intracellular signalling in primary neuronal cultures. In addition, we demonstrate that a single intracerebroventricular injection of R36 protein into a model of Reelin deficiency, the heterozygous reeler mice, can significantly improve cognition. These data support a role for the new construct R36 to enhance the Reelin pathway, and the future possibility of exploring gene therapy approaches with R36 in diseases characterized by reduced levels of Reelin.
Effect of high‐content ultrasonically emulsified lard on the physicochemical properties of surimi gels from silver carp enhanced by microbial transglutaminase
Authors: Tong Yuqian , Wang Yudong , Chen Min , Zhong Qian , Zhuang Yang , Su Hongchen , Yang Hong 
Published: March 2023

SummaryThe objective of this study was to investigate the effect of ultrasonically emulsified lard combined with microbial transglutaminase (MTGase) on the physicochemical characteristics of surimi gel from silver carp. Surimi gel with ultrasonically emulsified lard had higher whiteness, gel strength and water‐holding capacity. Storage modulus and loss modulus decreased with the addition of lard or ultrasonically emulsified lard to the surimi. However, the gel strength and WHC presented a decreasing tendency in surimi gels with more addition of ultrasonically emulsified lard, because the gel network could not overcome the damaging effect of higher ultrasonically emulsified lard (>6 g 100 g−1). MTGase increased the cross‐linking degree of gels (P < 0.05) regardless of the presence or absence of lard or ultrasonically emulsified lard. MTGase provided a denser and stronger gel network to ensure the stability of oil droplets. In general, the combination of ultrasonically emulsified lard and MTGase could effectively improve the color, textural and rheological characteristics of surimi‐based products.
Digital image analysis of erythroblastic islands in myelodysplastic syndromes
Authors: Zhang Ranran , Drumheller Bradley , Wang Li‐Ping , Obstfeld Amrom E. , Lake Jonathan I. , Bagg Adam 
Published: March 2023

AbstractIntroductionMyelodysplastic syndromes (MDS) encompass a diverse group of myeloid neoplasms for which the diagnosis of low‐grade subtypes remains challenging. Erythroblastic islands (EBIs) are highly organized units of erythroid proliferation, differentiation, and enucleation. EBI disruption is frequently observed and is believed to be one of the early changes in MDS.MethodsIn this study, we digitally analyzed bone marrow biopsies dual stained with alpha‐hemoglobin stabilizing protein (AHSP) and CD163 to quantitatively study features of EBIs in MDS, among MDS subtypes, as well as those in normal marrows and marrows with other causes of anemia.ResultsEBIs in MDS specimens were smaller in size and higher in density compared to both normal and non‐MDS anemia specimens. Increased CD163 expression within the EBIs is observed in both MDS and other causes of anemia. A combination of increased EBI density and CD163 expression is seen in association with MDS with high‐risk cytogenetics and multiple adverse mutations.ConclusionAs a proof‐of‐concept study, we show that EBI features can be relatively easily quantified with AHSP/CD163 dual immunohistochemistry and open‐source imaging analysis software, highlighting those that are unique to MDS, and which may be prognostically relevant. Further studies of the measurable EBI features may provide valuable and novel tools to aid MDS diagnosis and prognostication in the era of digital pathology.
Occlusive wound closure prevents prolonged wound discharge—A randomised controlled trial in patients undergoing tumour resection and endoprosthetic reconstruction of the proximal femur because of metastatic bone disease
Authors: Hettwer Werner H. , Wu Chunsen , Horstmann Peter F. , Jensen Claus L. , Krarup‐Hansen Anders , Petersen Michael M. 
Published: March 2023

AbstractProlonged wound discharge is a common postoperative complication of orthopaedic procedures and a risk factor for implant‐related infection. Occlusive wound closure methods have previously been suggested to reduce or even prevent this complication. We performed a randomised controlled trial on 70 patients who underwent surgical treatment for metastatic bone disease involving the proximal femur at our centre between January 2017 and August 2018. At conclusion of the tumour resection and endoprosthetic reconstruction procedure, patients were randomised to either occlusive wound closure (n = 35), using the Dermabond Prineo‐22 skin closure system, or routine wound closure with conventional skin staples (n = 35). Skin closure with occlusive wound closure resulted in a lesser degree (P < .0001) and shorter duration of postoperative wound discharge (HR 2.89 [95% CI 1.6–5.05], P < .0018). Compared with staples, surgical wounds were already dry after a mean of 3.5 days [95% CI 3.2–3.9] versus 6.1 days [95% CI 4.8–7.3] (P < .0001). Prolonged wound discharge for 7 days or more was observed in 23% of patients (n = 8) in the Staples‐group but was entirely absent in the occlusive wound closure group (P < .003). This study provides strong evidence that occlusive wound closure reduces frequency, degree, and duration of wound discharge in a patient population at particularly high risk for this complication.
Six-month effective treatment of corneal graft rejection
Authors: Meng Tuo , Zheng Jinhua , Chen Min , Zhao Yang , Sudarjat Hadi , M.R. Aji Alex , Kulkarni Vineet , Oh Yumin , Xia Shiyu , Ding Zheng , Han Hyounkoo , Anders Nicole , Rudek Michelle A. , Chow Woon , Stark Walter , Ensign Laura M. , Hanes Justin , Xu Qingguo 
Published: March 2023

Topical corticosteroid eye drop is the mainstay for preventing and treating corneal graft rejection. While the frequent topical corticosteroid use is associated with risk of intraocular pressure (IOP) elevation and poor patient compliance that leads to graft failure and the requirement for a repeated, high-risk corneal transplantation. Here, we developed dexamethasone sodium phosphate (DSP)–loaded dicarboxyl-terminated poly(lactic acid) nanoparticle (PLA DSP-NP) formulations with relatively high drug loading (8 to 10 weight %) and 6 months of sustained intraocular DSP delivery in rats with a single dosing. PLA DSP-NP successfully reversed early signs of corneal rejection, leading to rat corneal graft survival for at least 6 months. Efficacious PLA DSP-NP doses did not affect IOP and showed no signs of ocular toxicity in rats for up to 6 months. Subconjunctival injection of DSP-NP is a promising approach for safely preventing and treating corneal graft rejection with the potential for improved patient adherence.