bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formal guidelines from an expert panel: intensive care unit medical staffing, organisation and working hours to improve quality of life at work in France
Authors: Terzi Nicolas , Thiery Guillaume , Bèle Nicolas , Bigé Naike , Brossier David , Boyer Alexandre , Couty Edouard , Flender Laëtitia , Manzon Cyril , Mira Jean-Paul , Ortuno Sofia , Peigne Vincent , Poncet Marie-Cécile , Renolleau Sylvain , Rigaud Jean-Philippe , Vivet Bérengère , Kuteifan Khaldoun ,   the French Intensive Care Society (FICS), the French National Council of Intensive Care Medicine (CNP MIR, Conseil National Professionel de Médecine Intensive Réanimation)
Published: January 2025

Abstract

Background
Intensive care units (ICU) are characterized by high medical assistance costs and great complexity. Recommendations to determine the needs of medical staff are scarce, generating appreciable variability. The French Intensive Care Society (FICS) and the French National Council of Intensive Care Medicine (CNP MIR, Conseil National Professionel de Médecine Intensive Réanimation) have established a technical committee of experts, the purposes of which were to draft recommendations regarding staffing needs in ICUs and to propose optimal organisation of work hours, a key objective being improved workplace quality of life.

Results
Literature analysis was conducted according to the GRADE methodology (Grade of Recommendation Assessment, Development and Evaluation). The synthesis work of the experts according to the GRADE method led to the development of 22 recommendations in 6 field. The experts issued a strong recommendation associated with a high level of evidence which is that work organization be given priority during periods of permanent care, with a maximum 16 h of consecutive work permitted. For 21 other recommendations, the level of evidence did not allow GRADE classification, and led to the formulation of expert opinions. All recommendations and expert opinions were validated (strong agreement).

Conclusion
The work in the intensive care unit and in the intermediate intensive care unit is multifaceted, both clinical and non-clinical, and must include at least the following continuity and quality for patient safety. This document provides a detailed framework to propose an optimal medical staff.
Impact of frailty and older age on weaning from invasive ventilation: a secondary analysis of the WEAN SAFE study
Authors: Laffey Caoimhe M. , Sheerin Rionach , Khazaei Omid , McNicholas Bairbre A. , Pham Tài , Heunks Leo , Bellani Giacomo , Brochard Laurent , Tomescu Dana , Simpkin Andrew J. , Laffey John G. ,   on behalf of the WEAN SAFE Investigators
Published: January 2025

Abstract

Objective
To understand the impact of both frailty and chronologic age on outcomes of weaning from invasive mechanical ventilation (MV).

Methods
The study population consisted of patients enrolled in the ‘WorldwidE. AssessmeNt of Separation of pAtients From ventilatory assistancE (WEAN SAFE) study. We defined 4 non-overlapping groups, namely: ‘frail’ (clinical frailty scale [CFS] score > 4; age < 80 years); ‘elderly’ (CFS ≤ 4; age ≥ 80y), ‘frail \elderly’ (CFS > 4; age ≥ 80 years), and a ‘not frail or elderly’ population. The primary outcome was the impact of frailty and older age on delayed weaning and failed weaning from invasive MV. Secondary outcomes included the impact of frailty and age on ICU and hospital survival.

Results
In the study population, 760 (17%) were frail, while 360 (8%) were elderly, 197 (4%) were frail and elderly, while 3,176 (70%) were not frail or elderly. The frail and elderly cohorts were more likely to be female, had hypoxemic/hypercapnic respiratory failure or sepsis, and had more comorbidities. The proportion of delayed weaning and of failed weaning from invasive MV was significantly higher in the frail (28 and 23%), the elderly (25 and 19%), and the frail and elderly groups (22% and 25%), compared to the not frail or elderly population (12% and 13%, P < 0.01). ICU and hospital mortality was higher in the frail (21 and 33%), the elderly (19 and 31%), and the frail and elderly groups (26 and 46%), compared to the not frail or elderly population (12% and 18%, P < 0.001). In multivariate analyses, there was an independent association between frailty and delayed weaning initiation and weaning failure. Old age was independently associated with risk of weaning failure.

Conclusions
Frailty status had a more consistent impact than older age on weaning outcomes. However, overall outcomes in these cohorts are encouraging once separation attempts have been initiated.
The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views
Authors: Happy Kenneth , Yang Sungyu , Kang Chang Ho , Kang Youngmin 
Published: January 2025

Abstract

Aconitum kusnezoffii Reichb. is a medicinal plant widely used in traditional Asian medicine, especially in Korea, for its potent pharmacological effects. However, its toxic alkaloids pose significant risk, making careful processing essential to reduce its toxicity. This study reviewed the plant’s processing methods, pharmacological activities, phytochemistry, toxicology, and detoxification techniques. Data from several databases, including Google scholar, PubMed, Scopus, Web science, peer-reviewed journal articles, classic herbal medicine books, and Allied and Complementary Medicine Database (AMED) were critically retrieved, organized and analyzed. The article’s findings indicate that, various ethnic groups in Asia have utilized different techniques, involving fire, water, or a combination of both to maximize the plant’s therapeutic potential and ensure safety. To date, more than 70 alkaloids, categorized into diterpenoids, norditerpenoids, and benzylisoquinolines, have been isolated from different plant’s parts (roots, leaves, stems, and flowers). These compounds exhibit various pharmacological activities including anti-inflammatory, analgesics, anti-cancer, anti-tumor, anti-arhythmic and pain-relieving properties. Despite its therapeutic potential, A. kusenzoffii. has narrow therapeutic window, meaning even small doses can be toxic. The study explored methods for reducing toxicity and detoxifying the herb emphasizing the importance of modern technologies such as propagation techniques, Systematic Evolution of Ligands by Exponential Enrichment (SELEX)-aptamer technology, and Chinmedomics in herbal medicine development. While research on this herb is extensive, gaps remain in clinical trials and efficacy studies. Further research is recommended to evaluate the quality of medicinal materials, understanding the herb’s pharmacodynamic substances, and assess long-term toxicity and clinical efficacy.

Graphical Abstract
Gravity gradient model of the Antarctic region derived from airborne gravity and DEM
Authors: Shi Zhimin , Liang Xinghui , Liu Jinzhao , Ye Zhourun , Lang Junjian , Zhou Zhibo , Liu Lintao 
Published: January 2025

Abstract
In this paper, we augment airborne gravity anomaly data from Antarctica, expanding the coverage area by 10.4% based on the existing data set. These data are combined with a gravity field model to establish a more comprehensive gravity anomaly database for Antarctica. Utilizing the Integral of Stokes Kernels' Derivatives (ISKD) method, we create the first 10 km resolution gravity gradient map in the Antarctic region. According to measured data in the McFaulds Lake (located in the James Bay lowlands of northern Ontario, Canada), the proposed method achieves a calculation accuracy with a standard deviation (Std.) of 3–7 E (

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Graphical Abstract
The gendering of programmers’ work: taking China’s IT industry as an example
Authors: Li Xiaotian 
Published: January 2025

Abstract
This paper discusses the gendering of programmers’ work in China at both the occupational and work organization levels: the dichotomy between social and technical aspects in programming work leads to a gendered hierarchical division of labor that undermines the legitimacy of women programmers’ professional identities. Additionally, the combination of the overtime culture in technology companies and traditional gender role expectations makes women more likely to face work‒family conflicts. This paper uses the concept of embodiment to analyze women’s experiences of exclusion and women’s motivation to reconcile their gender and occupational identities and plan their career development. Thus, it simultaneously reveals how gender rules operate and how they may be changed in programming work.
Impact of Lower-Volume Training on Physical Fitness Adaptations in Team Sports Players: A Systematic Review and Meta-analysis
Authors: Clemente Filipe Manuel , Ramirez-Campillo Rodrigo , Moran Jason , Zmijewski Piotr , Silva Rui Miguel , Randers Morten Bredsgaard 
Published: January 2025

Abstract

Background
A small number of reviews have explored lower- versus higher-volume training in non-athletes, but the growing challenge of congested schedules in team sports highlights the need to synthesize evidence specific to team sport athletes. Thus, the objectives of this systematic review with meta-analysis are twofold: (i) to summarize the primary physiological and physical fitness outcomes of lower-volume versus higher-volume training interventions in team sports players; and (ii) to compare the effects of lower-volume training with higher, considering the training modalities used.

Methods
We conducted searches across key databases, including PubMed, Scopus, SPORTDiscus, and Web of Science. We included team sports players with at least a trained or developmental level, focusing on studies comparing different training volumes (lower vs higher) within the same research. Lower volume training was defined in comparison to another load, emphasizing smaller training volume in terms of repetitions, duration, or frequency. The studies had to examine key physical performance adaptations and use two-arm or multi-arm designs. Methodological assessments of the included studies were performed using the Rob2 and ROBINS-I instruments, with evidence certainty evaluated through GRADE.

Results
The initial search yielded 5,188 records, with 17 articles deemed eligible for the review. There was a non-significant trend favoring the higher-volume training group over the lower-volume group in resistance-based training when considering all pooled physical fitness outcomes (effect size − 0.05, 95% CI − 0.19 to 0.09, p = 0.506, I
2 = 0.0%). A meta-analysis was not conducted for aerobic-based training due to only two studies being available, with one showing that lower volume training improved maximal oxygen uptake by 3.8% compared to 1.3% for higher volume, while the other indicated that lower training volumes enhanced performance by 1.6% versus 0.8%. The evidence certainty for physical performance outcomes was very low.

Conclusions
In newly introduced resistance training, lower volumes—regardless of repetitions or frequency—can achieve similar fitness gains to higher volumes. More pronounced tapering also appears more effective for supercompensation. However, the variability in study designs and training methods makes it difficult to establish a clear minimal dose. The main contribution of this review is mapping current research, providing a foundation for future studies and training optimization.
Bispecific antibodies and CLEM: an analytical approach to advanced cell imaging for therapeutic strategies
Authors: Kim Han-ul , Kim Young Kwan 
Published: January 2025

Abstract
The development of bispecific antibodies (BsAbs) represents a significant advancement in therapeutic antibody design, enabling the simultaneous targeting of two different antigens. This dual-targeting capability enhances therapeutic efficacy, particularly in complex diseases like cancer, where tumor heterogeneity presents a significant challenge for traditional treatments. By bridging two distinct pathways, BsAbs can improve specificity and minimize off-target effects, making them invaluable in therapeutic contexts. Integrating advanced imaging techniques, particularly Correlative Light and Electron Microscopy (CLEM), offers a unique opportunity to visualize the dynamic interactions of BsAbs within cellular environments. CLEM combines the strengths of optical and electron microscopy, allowing researchers to observe real-time antibody-antigen interactions at nanoscale resolution. This synergy not only deepens our understanding of BsAbs’ mechanisms of action but also provides critical insights into their spatial distribution, binding kinetics, and functional dynamics in live cells. In this review, the integration of BsAbs and CLEM paves the way for targeted therapeutic strategies, fostering the development of more effective treatments that can adapt to the complexities of disease pathology.
Association of VEGF promoter polymorphisms with gastrointestinal tract cancer risk and therapy response: a systematic review
Authors: Mahajan Deepanshi , Sambyal Vasudha , Guleria Kamlesh 
Published: January 2025

Abstract

Background
Gastrointestinal tract (GIT) cancers are the most lethal cancers with a high incidence and poor prognosis. Vascular endothelial growth factor (VEGF) glycoprotein plays an essential role in tumour neovascularization, especially in cancers of the gastrointestinal tract. There are numerous functional polymorphisms reported in the VEGF which lead to either upregulation or downregulation of VEGF expression.

Objective
The present review focuses on the role of VEGF functional polymorphisms in influencing the risk and prognosis of various GIT cancers.

Method of study
This systematic review was done by Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, and Participant, Intervention, Comparison, Outcomes and Studies (PICOS) criteria were followed for designing the study. A total of 183 articles were retrieved from Google Scholar, PubMed and ScienceDirect using various keywords. After full-text evaluation and applying the literature selection criteria, 108 articles were selected in the review. The role of VEGF promoter polymorphisms in influencing various transcription factor binding sites (TFBS) in the VEGF promoter was studied by performing an in silico analysis.

Results
This review article summarized the findings of the studies on the associations of VEGF promoter polymorphisms with various GIT cancers. The effect of the VEGF promoter polymorphisms on cancer risk and prognosis varied between different ethnicities and different GIT cancers. The in silico analysis revealed that the VEGF polymorphisms alter the TFBS, leading to attenuation of the functional activity of the transcription factors which might have importance in the GIT cancer development.

Conclusion
VEGF is as an important biomarker for studying the disease susceptibility, progression and prognosis in GIT cancers.
Apoptosis induction and tumor growth suppression by hydroxyapatite nanoparticles–cisplatin combined treatment in Ehrlich solid carcinoma-bearing mice
Authors: Eissa Shaymaa M. , Mahfouz Asmaa M. , El-Gendy Saad M. , Zakaria Al-shimaa , Effat Heba , Mohamed Hanan R. H. 
Published: January 2025

Abstract

Background
Hydroxyapatite (HAP) resembles the components of biological hard tissue. Recent research has been interested in the biomedical application of HAP nanoparticles (HAP-NPs) in cancer treatment, HAP-NPs have high cytotoxic activity against cancerous cells, in addition, they are nontoxic to healthy normal cells, biocompatible, biodegradable, and have a high absorption rate within the tissue. Therefore, this study evaluated HAP-NPs' antitumoral activity in Ehrlich solid carcinoma (ESC)-bearing mice, in addition, we examined the anticancer efficacy of combined treatment of a common chemotherapeutic drug such as Cisplatin (CDDP) and HAP-NPs in ESC-bearing mice.

Methods
Forty female mice were inoculated with 200 µl of diluted ascites fluid containing approximately two million viable cancer cells in the mice's left thigh, after 14 days of inoculation, the mice were distributed into four groups: 10 mice in each. ESC group was administrated distilled water, the HAP-NPs group was treated orally with 100 mg/kg of hydroxyapatite nanoparticles, the CDDP group was administrated intraperitoneally with 5 mg/kg of Cisplatin, the HAP-NPs + CDDP group was treated with both doses of hydroxyapatite and cisplatin, the animal treatment was conducted for 20 days. Antitumor activity was assessed for two durations after 10 and 20 days. DNA damage assessment was performed using comet assay in ESC, in addition, we measured the expression of the following genes (P53, Bcl2, and Bax,) using quantitative real-time PCR, and the apoptotic-related proteins (P53 and Ki-67) using immunohistochemical analysis. A histopathological examination of ESC was performed.

Results
The obtained data illustrated a promising anticancer activity of HAP-NPs, and the combined treatment of HAP-NPs and CDDP illustrated a higher anticancer efficacy. HAP-NPs, CDDP, and HAP-NPs + CDDP resulted in significant (P < 0.05) nucleic acid destruction, and significant (P < 0.05) overexpression of apoptotic-related genes (P53, Bax, and Bcl2) and proteins (Ki-67 and P53), causing the tumor bulk to be greatly reduced in HAP-NPs, CDDP, and HAP-NPs + CDDP (1100, 570, and 450 mm3), respectively, compared to ESC group was 2240 mm3.

Conclusion
Hydroxyapatite nanoparticles can provoke DNA damage and regulate apoptosis, selectively eliminating tumor cells. The co-administration of HAP-NPs and CDDP resulted in a synergistic enhancement of cisplatin activity within the tumor tissue.
Assessing prevalence and predictors of impaired awareness of hypoglycemia in type 2 diabetes patients with chronic kidney disease
Authors: Soliman Amin , Atef El Kordy Noran , Mostafa Faris Farouk , Mahmoud Ahmed Rabab 
Published: January 2025

Abstract

Background
This study aims to determine the prevalence of impaired awareness of hypoglycemia (IAH) across all chronic kidney disease stages in patients with type 2 diabetes mellitus and to identify predictors of impaired awareness of hypoglycemia within these patients.

Methods
Clinical and laboratory data were extracted from patient medical records. Participants were interviewed using validated modified Clarke’s questionnaire and Gold score to assess impaired awareness of hypoglycemia.

Results
Cross sectional study included 480 participants diagnosed with chronic kidney disease and type 2 diabetes. The overall prevalence of impaired awareness of hypoglycemia (IAH) was 34.6% (166 patients) according to the Clarke questionnaire and 34.4% by the Gold Score (165 patients). This prevalence varied significantly across different CKD stages, with higher rates in stage 3 (P value = 0.001). The mean impaired awareness of hypoglycemia scores were 3.98 ± 1.34 (Clarke) and 3.92 ± 1.52 (Gold), with advanced CKD stages showing statistically significant elevated scores (p value ≤ 0.05). In the 166 patients with impaired awareness of hypoglycemia, a statistically significant higher incidence of severe hypoglycemia was observed in hemodialysis patients (p value = 0.01). Most of patients with impaired awareness of hypoglycemia aged > 60 years, had more prevalent hypertension and had lower HbA1c levels (P value ≤ 0.05). However, Multivariate logistic regression analysis found that age > 60 years was a significant independent risk factor with an 8% higher risk for IAH (P = 0.01), (OR 1.08, 95% CI 1.01–1.16).

Conclusion
The present study is unique in investigating impaired awareness of hypoglycemia (IAH) across the full spectrum of chronic kidney disease (CKD) stages, including patients on hemodialysis. Approximately one-third of CKD patients with type 2 diabetes mellitus exhibited a general lack of awareness of hypoglycemia. Patients with stage 3 CKD showed the highest prevalence of IAH. Those already experiencing IAH and receiving hemodialysis faced more severe hypoglycemic episodes. Age over 60 years was an independent risk factor for hypoglycemia unawareness in this patient group. Larger wide scale studies are needed to further validate these results.
The effect of bilingualism on obligatory components of auditory late responses in young adults: a cross-sectional study
Authors: Hajimohammadi Ali , Heidari Fatemeh 
Published: January 2025

Abstract

Introduction
Bilingualism significantly contributes to neuroplasticity in the brain, with research indicating enhanced auditory processing in bilingual individuals. Obligatory sensory components of the auditory late responses (ALRs) reflect primary and secondary auditory cortex activity, serving as an electrophysiological measure of auditory processing. This study aims to compare ALRs' obligatory components (P1-N1-P2) in bilingual (Turkish-Persian) and monolingual (Persian) young adults.

Method
This cross-sectional study analyzed ALRs in 28 monolingual and 28 bilingual participants aged 19 to 30 years, using a 70 dB nHL speech stimulus (/da/). ALRs were recorded monaurally with insert earphones. The study then compared the mean latency and amplitude of P1- N1- P2 complex in the right and left ear between two groups.

Result
The study revealed shorter latency for all three ALRs components in bilingual participants compared to monolinguals. This difference was statistically significant (P-value < 0.05) for N1 with right ear stimulation and P2 with right and left ear stimulations. No significant differences were found in the amplitude of P1-N1 and N1-P2 between the groups.

Conclusion
The significant reduction in N1 and P2 latency observed in bilingual subjects' ALRs likely results from neural plasticity. This may enhance neural transmission and accelerate speech sound processing in the respective cortical regions. These latency changes could serve as a cortical neural biomarker distinguishing monolinguals from bilinguals, highlighting the impact of bilingualism on auditory processing efficiency.
Static Planck stars from effective loop quantum gravity
Authors: Wilson-Ewing Edward 
Published: January 2025

Abstract
Effective loop quantum gravity dynamics are derived for spherically symmetric spacetimes with a perfect fluid matter content. For homogeneous spacetimes, the effective dynamics agree with the standard results of loop quantum cosmology, while the equations for static solutions give an effective Tolman-Oppenheimer-Volkoff equation. There exist solutions to the effective Tolman-Oppenheimer-Volkoff equation that have a mass of the order of the Planck mass, a Planckian radius, and no horizon; these miniature stars could potentially contribute to dark matter, and could be an end state for an evaporating black hole.