bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Port Placement in Robotic-assisted DIEP Flap Harvest Improves Visibility and Bilateral DIEP Access: Early Controlled Cohort Study
Authors: Tsai Chun-Yi , Kim Bong-Sung , Kuo Wen-Ling , Liu Keng-Hao , Chang Tommy Nai-Jen , Cheong David Chon-Fok , Huang Jung-Ju 
Published: March 2023

Summary:
To minimize the donor site damage, robotic-assisted DIEP (RA-DIEP) flap harvest was suggested recently. Present robotic approaches favor port placement which either do not allow a bilateral DIEP flap harvest through the same ports or necessitate additional scars. Herein, we propose a modification of port configuration.
In a retrospective controlled cohort study, RA-DIEP and conventional DIEP surgeries were compared. The perforator and pedicle were conventionally visualized until the level behind the rectus abdominis muscle. Next, the robotic system was installed to dissect the retro-muscular pedicle. We assessed patient age, BMI, history of smoking, diabetes mellitus, hypertension, and additional surgical time. The ARS incision length was measured. Pain was quantified by the visual analogue scale. Donor site complications were assessed.
Thirteen RA-DIEP flaps (11 unilateral, 2 bilateral) and 87 conventional DIEP flaps were harvested without flap loss. The bilateral DIEP flaps were raised without re-adjustments of the ports. The mean time for pedicle dissection was 53.2 ± 13.4 min. The ARS incision length was significantly shorter in the RA-DIEP group (2.67 ± 1.13 cm vs 8.14 ± 1.69, 304.87 % difference, p < 0.0001). There was no statistical difference in postoperative pain (day 1: 1.9 ± 0.9 vs 2.9 ± 1.6, p = 0.094; day 2: 1.8 ± 1.2 vs 2.3 ± 1.5, p = 0.319; day 3: 1.6 ± 0.9 vs 2.0 ± 1.3, p = 0.444).
Preliminary results show that our RA-DIEP approach is safe and allows dissection of bilateral RA-DIEP flaps with short ARS incision length.
Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome
Authors: Berardi Giammauro , Ivanics Tommy , Sapisochin Gonzalo , Ratti Francesca , Sposito Carlo , Nebbia Martina , D’Souza Daniel M. , Pascual Franco , Tohme Samer , D’Amico Francesco Enrico , Alessandris Remo , Panetta Valentina , Simonelli Ilaria , Del Basso Celeste , Russolillo Nadia , Fiorentini Guido , Serenari Matteo , Rotellar Fernando , Zimitti Giuseppe , Famularo Simone , Hoffman Daniel , Onkendi Edwin , Lopez-Ben Santiago , Caula Celia , Rompianesi Gianluca , Chopra Asmita , Abu Hilal Mohammed , Torzilli Guido , Corvera Carlos , Alseidi Adnan , Helton Scott , Troisi Roberto I. , Simo Kerri , Conrad Claudius , Cescon Matteo , Cleary Sean , Kwon Choon H. D. , Ferrero Alessandro , Ettorre Giuseppe M. , Cillo Umberto , Geller David , Cherqui Daniel , Serrano Pablo E. , Ferrone Cristina , Mazzaferro Vincenzo , Aldrighetti Luca , Kingham T. Peter 
Published: March 2023

Objective:
To compare minimally invasive (MILR) and open liver resections (OLRs) for hepatocellular carcinoma (HCC) in patients with metabolic syndrome (MS).

Background:
Liver resections for HCC on MS are associated with high perioperative morbidity and mortality. No data on the minimally invasive approach in this setting exist.

Material and Methods:
A multicenter study involving 24 institutions was conducted. Propensity scores were calculated, and inverse probability weighting was used to weight comparisons. Short-term and long-term outcomes were investigated.

Results:
A total of 996 patients were included: 580 in OLR and 416 in MILR. After weighing, groups were well matched. Blood loss was similar between groups (OLR 275.9±3.1 vs MILR 226±4.0, P=0.146). There were no significant differences in 90-day morbidity (38.9% vs 31.9% OLRs and MILRs, P=0.08) and mortality (2.4% vs 2.2% OLRs and MILRs, P=0.84). MILRs were associated with lower rates of major complications (9.3% vs 15.3%, P=0.015), posthepatectomy liver failure (0.6% vs 4.3%, P=0.008), and bile leaks (2.2% vs 6.4%, P=0.003); ascites was significantly lower at postoperative day 1 (2.7% vs 8.1%, P=0.002) and day 3 (3.1% vs 11.4%, P<0.001); hospital stay was significantly shorter (5.8±1.9 vs 7.5±1.7, P<0.001). There was no significant difference in overall survival and disease-free survival.

Conclusions:
MILR for HCC on MS is associated with equivalent perioperative and oncological outcomes to OLRs. Fewer major complications, posthepatectomy liver failures, ascites, and bile leaks can be obtained, with a shorter hospital stay. The combination of lower short-term severe morbidity and equivalent oncologic outcomes favor MILR for MS when feasible.
Distal Pancreatectomy With En Bloc Celiac Axis Resection (DP-CAR) for Locally Advanced Pancreatic Cancer
Authors: Loos Martin , Khajeh Elias , Mehrabi Arianeb , Kinny-Köster Benedict , Al-Saeedi Mohammed , Berchtold Christoph , Hoffmann Katrin , Schneider Martin , Eslami Pegah , Feisst Manuel , Hinz Ulf , Hackert Thilo , Büchler Markus W. 
Published: March 2023

Objective:
To determine perioperative and oncologic outcomes after distal pancreatectomy with en bloc resection of the celiac axis (DP-CAR).

Background:
DP-CAR can be used in a selective group of patients to resect locally advanced pancreatic cancer involving the celiac axis or common hepatic artery without arterial reconstruction by preserving retrograde blood flow via the gastroduodenal artery to the liver and stomach.

Methods:
We analyzed all consecutive patients who had undergone DP-CAR between May 2003 and April 2022 at a tertiary hospital specialized in pancreatic surgery and present one of the largest single-center studies.

Results:
A total of 71 patients underwent DP-CAR. Additional venous resection (VR) of the mesenterico-portal axis was performed in 31 patients (44%) and multivisceral resection (MVR) in 42 patients (59%). Margin-free (R0) resection was achieved in 40 patients (56%). The overall 90-day mortality rate was 8.4% for the entire patient cohort. After a cumulated experience of 16 cases, the 90-day mortality dropped to 3.6% in the following 55 patients. Extended procedures with (+) additional MVR with or without (+/−) VR resulted in higher major morbidity (Clavien–Dindo ≥IIIB; standard DP-CAR: 19%; DP-CAR + MVR +/− VR: 36%) and higher 90-day mortality (standard DP-CAR: 0%; DP-CAR + MVR +/− VR: 11%). Median overall survival after DP-CAR was 28 months.

Conclusions:
DP-CAR is a safe and effective procedure but requires experience. Frequently, surgical resection has to be extended with MVR and VR to accomplish tumor resection, which results in promising oncologic outcomes. However, extended resections were associated with increased morbidity and mortality.
The effect of estradiol during the early stages of osteoclast differentiation is associated with the accumulation of phosphorylated p53 in mitochondria and the inhibition of mitochondrial metabolism
Authors: Marques-Carvalho Adriana , Silva Beatriz , Pereira Francisco B. , Kim Ha-Neui , Almeida Maria , Sardão Vilma A. 
Published: March 2023

ABSTRACTEstrogen deficiency increases bone resorption and is a major contributor to osteoporosis. However, the molecular mechanisms mediating the effects of estrogen on osteoclasts remain unclear. This study aimed at elucidating the early metabolic effects of RANKL – the essential cytokine for osteoclastogenesis – and 17-beta-estradiol (E2) on osteoclast progenitor cells, using RAW 264.7 macrophage cell line and bone marrow-derived macrophages as biological models. RANKL stimulated complex I activity, oxidative phosphorylation (OXPHOS), and mitochondria-derived ATP production, as early as 3 to 6 h. This up-regulation of mitochondrial bioenergetics was associated with an increased capacity to oxidize TCA cycle substrates, fatty acids, and amino-acids. E2inhibited all effects of RANKL on mitochondria metabolism. In the presence of RANKL, E2also decreased cell number and stimulated the mitochondrial-mediated apoptotic pathway, detected as early as 3h. Surprisingly, the pro-apoptotic effects of E2were associated with an accumulation of p392S-p53 in mitochondria. These findings elucidate early effects of RANKL on osteoclast progenitor metabolism and suggest novel p53-mediated mechanisms that contribute to postmenopausal osteoporosis.
Elite women's clubs in the 1930s across three Australian states: a prosopographical study
Authors: May Josephine 
Published: March 2023

PurposeThe purpose of this paper is to explore the clubs and club memberships of 491 elite women in three eastern Australian states in the 1930s. It is the second part of a descriptive analysis of these women's biographical sketches in Who's Who-type collections, now out of copyright, published in Australia in the 1930s: Victoria (1934), New South Wales (1936) and Queensland (1939).Design/methodology/approachUsing mixed methods within a prosopographical approach, described fully in the first paper on these data, this is mainly a quantitative analysis. After the numbers of club memberships of the women are given and compared on a state-by-state basis, a taxonomy of five main types of clubs was created and the clubs and club memberships listed for each of them. The five types are: (1) social and cultural clubs; (2) sporting clubs; (3) imperial, national and patriotic clubs; (4) professional clubs; and (5) service and educational clubs. The paper then explores the similarities and variations at the state level in the women's club memberships across the five types. It should be noted that the article does not include charities to which the women contributed because they required a separate typology and analysis to be taken up elsewhere.FindingsThe paper frames women's clubs as informal educative networks where women were able to acquire the knowledge and skills in modernity for effective participation in the public sphere. The analysis shows that three-quarters of the 491 women were members of one club or more. Overall, the women listed 340 separate clubs with 1,029 memberships across the five types. The state-by-state analysis giving lists of clubs, and numbers of memberships per club in each type, enumerated variations of women's clubs at the state level. Overall, the analysis suggests that the “club habit” for such women was a substantial historical phenomenon at this time.Originality/valueThis is the first study to encompass women's club memberships across three Australian states. Quantification of women's involvement in clubs has proved difficult, however, by using a prosopographical approach, this study creates a unique quantitative picture of the club data contained in 491 elite women's biographical sketches from the 1930s.
THE HOUSING/FINANCIAL COMPLEX IN SPAIN: After the 2008 Global Financial Crisis
Authors: Bonshoms‐Guzmán Jordi 
Published: March 2023

AbstractThe 2008 global financial crisis prompted a tectonic shift in the Spanish model, which was based on a debt‐driven homeownership society. In the aftermath of the financial crash, the restructuring of the real estate and financial market through intervention of the Spanish government has been a privileged object of urban analysis, with scholars researching the role of the Management Company for Assets Arising from Bank Reorganization (SAREB) and Spanish real estate investment trusts (REITs) in deleveraging the overhang of nonperforming mortgages from banks. This focus has nonetheless led to neglect of the central role of privately funded asset management companies (AMCs) in Spain, which have not figured highly in urban discussions about post‐2008‐financial‐crisis housing restructuring. In this article, which emanates from a larger study examining the re‐setting of relations between real estate and financial actors in Spain, I argue that research should pay more attention to the role of privately funded AMCs. I contend that AMCs function as the operational infrastructures of financialization on behalf of investment funds, as they transform nonperforming mortgages into income‐producing assets in the housing sector. Analyses of the role of AMCs also help us better understand the role of Spanish REITs owned by investment funds. Through a detailed examination of the Spanish institutional structure that links housing with financial channels, and by introducing the key role of AMCs at the nexus of such a link, in this article I outline the operations of the emerging housing/financial complex in Spain in the aftermath of the 2008 financial crisis.
The effects of patient out‐of‐pocket costs on insulin use among people with type 1 and type 2 diabetes with Medicare Advantage insurance—2014–2018
Authors: McAdam‐Marx Carrie , Ruiz‐Negron Natalia , Sullivan Jane M. , Tucker Jamie M. 
Published: March 2023

AbstractObjectiveTo identify the association between insulin out‐of‐pocket costs (OOPC) and adherence to insulin in Medicare Advantage (MA) patients.Data Sources and Study SettingThe study is based on Optum Labs Data Warehouse, a longitudinal, real‐world data asset with de‐identified administrative claims and electronic health record data.Study DesignUsing descriptive and multivariable logistic regression analyses, we identified the likelihood of patients with diabetes having ≥60 consecutive days between an expected insulin fill date and the actual fill date (refill lapse) by OOPC, categorized by $0, >$0–$20 (reference), >$20–$35, >$35–$50, and > $50 per 30‐day supply.Data Collection/Extraction MethodsThe study included MA enrollees with type 1 or type 2 diabetes and prescription claims for insulin between 2014 and 2018.Principal FindingsThose with average insulin OOPC per 30‐day supply >$35 or $0 were more likely to have an insulin refill lapse versus OOPC of >$0 to $20, with odds ratios ranging 1.18 (95% CI 1.13–1.22) to 1.74 (95% CI 1.66–1.83) depending on OOPC group and diabetes type.ConclusionsCapping average insulin OOPC at $35 per 30‐day supply may help avoid cost‐related insulin non‐adherence in MA patients; efforts to address non‐cost barriers to medication adherence remain important.
The association of race and ethnicity on obstetric patients’ COVID‐19 outcomes: A summary of current literature
Authors: Mathew Dave M. , Ampatey Nicole A. , Aaronson Jaime A. , Samuels Jon D. , McCullough Danielle , White Robert S. 
Published: March 2023

AbstractAmidst the ongoing coronavirus disease 2019 (COVID‐19) pandemic, evidence suggests racial and ethnic disparities in COVID‐19‐related outcomes. Given these disparities, it is important to understand how such patterns may translate to high‐risk cohorts, including obstetric patients. A PubMed search was performed to identify studies assessing pregnancy, neonatal, and other health‐related complications by race or ethnicity in obstetric patients with COVID‐19 infection. Forty articles were included in our analysis based on novelty, relevance, and redundancy. These articles revealed that Black and Hispanic obstetric patients present an increased risk for SARS‐CoV‐2 infection and maternal mortality; racial and ethnic minority patients, particularly those of Black and Asian backgrounds, are at increased risk for hospitalization and ICU admission; racial and ethnic minority groups, in particular Black patients, have an increased risk for mechanical ventilation; Black and Hispanic patients are more likely to experience dyspnea; Hispanic patients showed higher rates of pneumonia; and Black patients present an increased risk of acute respiratory distress syndrome (ARDS). There is conflicting literature on the relationship between race and ethnicity and various pregnancy and neonatal outcomes. Several factors may underly the racial and ethnic disparities observed in the obstetric population, including biological mechanisms and social determinants of health.
Paediatric negative appendicectomy rates at a regional Western Australian Centre: a five‐year cohort study
Authors: Behrendorff Natasha , Palan Ranesh , McKitterick Tommy , Cover Jacinta 
Published: March 2023

AbstractBackgroundIn acute appendicitis, decision‐making around operative intervention for paediatric patients differs from adults due to a higher weight placed on clinical assessment and reduced rates of cross‐sectional imaging. In regional settings, non‐paediatric emergency doctors, general surgeons, and radiologists usually assess and manage this patient group. Differences have been observed in paediatric negative appendicectomy rates between general and paediatric centres.MethodsA retrospective cohort study was performed, identifying paediatric patients undergoing emergency appendicectomy at the Southwest Health Campus (Bunbury, Western Australia) from 2017 to 2021. The primary outcome measure was histopathology confirming the absence of transmural inflammation of the appendix. In addition, clinical, biochemical and radiological data were collected to identify predictors of negative appendicectomy (NA). Secondary outcome measures were hospital length‐of‐stay and post‐operative complication rates.ResultsFour hundred and twenty‐one patients were identified, of which 44.9% had a negative appendicectomy. Statistically significant associations between female gender, white cell count less than 10 × 109, neutrophil ratio less than 75%, low CRP and NA were observed. NA was not associated with a lower risk of re‐admission or complications compared with appendicectomy for appendicitis.ConclusionsOur centre's NA rate is higher than that observed in the literature at both non‐paediatric and paediatric surgical centres. NA has similar morbidity risk to appendicectomy for uncomplicated appendicitis and offers a timely reminder that diagnostic laparoscopy in children is not benign.
Decomposing the changes in poverty: Poverty line and distributional effects
Authors: Aristondo Oihana , D'Ambrosio Conchita , Lasso de la Vega Casilda 
Published: March 2023

AbstractWhen measuring poverty in developed countries, the poverty line used to identify the poor is usually relative and set as a percentage of the median (or of the mean) of the total income. In consequence, when poverty is analyzed over a period of time, changes in the poverty level depend on the impact of evolving standards. To eliminate this effect, sometimes, an anchored poverty line is used. Furthermore, changes in the mean of the distribution and in the inequality among the poor may also affect the poverty levels. This note proposes a decomposition of the changes in poverty as the sum of four terms. The first two reflect the impact in poverty of changes in living standards and the other two measure the effect of the distributional growth and redistribution. This decomposition will help policymakers in the implementation of a more specific antipoverty agenda. An application with data from the European Union Survey on Income and Living Conditions shows the potential of the decomposition proposed.
Identification and characterization of odorant‐binding protein genes in the brown‐winged green bug, Plautia stali
Authors: Taniai Kiyoko , Suetsugu Yoshitaka , Miyazawa Mitsuhiro 
Published: March 2023

AbstractThe brown‐winged green bug, Plautia stali Scott (Hemiptera: Pentatomidae), is a major pest in orchards in Japan and Korea. Large numbers of adults are attracted by aggregation pheromone [methyl (E,E,Z)‐2,4,6‐decatrienoate] and cause extensive damage to the fruit. To identify olfactory‐related genes in P. stali, we performed RNA sequencing (RNA‐seq) of adult antennae. Among the 27299 contigs, 16 putative odorant‐binding protein (OBP) genes were identified and designated as PstaOBP1–16, including 10 classic (i.e., containing six conserved cysteines) and six Plus‐C (i.e., containing more than six cysteines) OBP genes. Quantitative reverse‐transcription polymerase chain reaction (qRT‐PCR) revealed that four genes (PstaOBP1, 3, 6, and 7) were strongly expressed in the antennae. PstaOBP2 was detected throughout the insect body, with higher expression in the antennae, stylet, and tarsus. The remaining OBP genes were expressed in very small amounts. PstaOBP1, which showed the highest expression in adult antennae, was expressed in Escherichia coli (Migula) Castellani & Chalmers cells and the recombinant protein was subjected to a ligand‐binding competitive assay. PstaOBP1 bound to methyl (E,E,Z)‐2,4,6‐decatrienoate with high affinity. Of the other 26 compounds tested, hinokitiol and tropolone bound strongly to PstaOBP1. Hinokitiol is an odor component of hinoki cypress, a host tree of P. stali. Electrophysiological responses to methyl (E,E,Z)‐2,4,6‐decatrienoate and hinokitiol were detected using adult P. stali antennae. Combined, these results suggest that PstaOBP1 is involved in P. stali responses to pheromone and host plant volatiles.
Are perch (Perca fluviatilis L.) getting larger or smaller in Swedish lakes?
Authors: Kerstin Holmgren , Petersson Erik 
Published: March 2023

AbstractSpace‐for‐time approaches are often used to indicate current or future changes over time. A European gillnet standard facilitates spatial‐scale comparisons of fish communities in European lakes. Fish size was generally lower and densities higher in warmer lakes, but less is known about trends over decadal time scales. We analysed the size of European perch (Perca fluviatilis L.) in 2121 Swedish lakes sampled during 1996–2021. The aim was to test whether size changed over time, and whether trends were similar in southern and northern regions. We analysed mean length and occurrence or relative abundance of size classes from the smallest (<100 mm) to the largest individuals (≥350 mm), and length at 1 and 5 years. The large data set was used to find general trends over time within regions, and within‐lake trends were tested for 40 time‐series lakes. The mean length of perch decreased in the southern and increased in the northern region. The proportion of the smallest perch increased in the southern, but not in the northern region. The most general trend was an increasing occurrence and proportion of the largest‐sized perch in both regions in the large dataset. The average trends in the southern region of the large dataset also appeared as predominant trends within time‐series lakes, although opposite trends occurred within some lakes in each region. This study also revealed that perch size at age 1 often increased within lakes over time, while more variable trends were found for size at age 5. The duration of the growth season has generally increased during the time frame of the present study, while other changes may differ between lakes in the same region. We recommend more studies based on time series of fish monitoring, including studies on possible reasons for the increased occurrence of very large perch in Swedish lakes.
IKZF1plus alterations are not associated with outcomes in Philadelphia‐positive acute lymphoblastic leukemia patients enrolled in the FBMTG ALL/MRD2008 trial
Authors: Ito Yoshikiyo , Ozawa Hidetoshi , Eto Tetsuya , Miyamoto Toshihiro , Kamimura Tomohiko , Ogawa Ryosuke , Uchida Naoyuki , Wake Atsusi , Fujisaki Tomoaki , Ohno Yuju , Takase Ken , Okumura Hirokazu , Takamatsu Yasushi , Kawano Noriaki , Akashi Koichi , Nagafuji Koji 
Published: March 2023

AbstractObjectiveThe prognostic significance of IKZF1plus in adult Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) patients had remained to be clarified.MethodsWe conducted a prospective, multicenter study, the ALL/MRD2008 trial, and investigated the clinical significance of IKZF1plus.ResultsFrom December 2008 to November 2013, 38 untreated Ph+ ALL patients were enrolled. At the end of the induction, 97.4% of patients (37/38) achieved complete hematological remission, with MRD‐negativity of 48.6% (18/37). There were 19 patients with IKZF1plus, 13 with IKZF1 deletion alone (ΔIKZF1) and 4 with no IKZF1 deletions (no ΔIKZF1). The probability of 3‐year DFS and OS in these Ph+ ALL patients were 50% (95% confidence interval [CI], 33–65) and 55% (95% CI, 38–69), respectively. There was no significant difference between IKZF1plus, ΔIKZF1, and no ΔIKZF1 in DFS (47%, 54%, 75% [p = .63]) or OS (47%, 62%, NA [p = .39]).ConclusionsWe revealed no relationship between IKZF1plus status and survival outcomes in Ph+ ALL patients treated with imatinib/dasatinib combination chemotherapy. Further investigations are warranted to clarify the prognostic significance of IKZF1plus in adult Ph+ ALL patients.