bluuebunny/crossref_metadata_2025_split huggingface dataset:
First successful head‐start program of leatherback sea turtles (Dermochelys coriacea) in Thailand and proposed dietary strategy
Authors: Kanghae Hirun , Thongprajukaew Karun , Suraswadi Pinsak , Namwang Areeya , Reungkhajorn Aisawan , Wongwilai Guntaphon , Intaring Boontika , Chamnivikaipong Chankit 
Published: August 2023

AbstractLeatherback sea turtle (Dermochelys coriacea) hatchlings have previously been kept alive for over a year in captive conditions but these were the few survivors of initially larger groups. In this report, newly hatched leatherback sea turtles were randomly harvested from two nests in Thailand and successfully reared before release back to the wild. In captivity, the survival of the turtles decreased sharply during the first 4 or 5 months, and then steadied until the end of the 12‐month trial. The survival of yearlings from one nest was 13.3% and from the other nest 46.7%. Their growth was exponential, reaching 1.36−3.35 kg (n = 9) at the end of program. The causes of death of the reared turtles were accidents (25.0−38.5%) and infections from water and live food (61.5−75.0%). The dietary requirements of the turtles were investigated by determining the digestibility of protein and carbohydrate in vitro, using enzymes from the digestive tracts of hatchlings that had died in an accident (70.1−92.9 g body weight). The results indicated that the most suitable source of protein was wheat gluten, followed by soybean meal, nonruminant meat and bone meal, fish meal, nonruminant meat meal, pork meal, and skimmed milk, while suitable carbohydrate sources were mashed cassava, corn, wheat flour, and alpha starch, followed by cereal meal and rice flour. Findings from the current report provide a practical protocol for head‐starting leatherback sea turtles, and indicate the possible basis of an effective artificial diet for this species.
Bootstrapping the relativistic two-body problem
Authors: Dlapa Christoph , Kälin Gregor , Liu Zhengwen , Porto Rafael A. 
Published: August 2023

Abstract
We describe the formalism to compute gravitational-wave observables for compact binaries via the effective field theory framework in combination with modern tools from collider physics. We put particular emphasis on solving the ‘multi-loop’ integration problem via the methodology of differential equations and expansion by regions. This allows us to bootstrap the two-body relativistic dynamics in the Post-Minkowskian (PM) expansion from boundary data evaluated in the near-static (soft) limit. We illustrate the procedure with the derivation of the total spacetime impulse in the scattering of non-spinning bodies to 4PM (three-loop) order, i.e. $$ \mathcal{O} $$
O
(G4), including conservative and dissipative effects.
Present and future constraints on flavor-dependent long-range interactions of high-energy astrophysical neutrinos
Authors: Agarwalla Sanjib Kumar , Bustamante Mauricio , Das Sudipta , Narang Ashish 
Published: August 2023

AbstractThe discovery of new, flavor-dependent neutrino interactions would provide compelling evidence of physics beyond the Standard Model. We focus on interactions generated by the anomaly-free, gauged, abelian lepton-number symmetries, specificallyLe–Lμ,Le–Lτ, andLμ–Lτ, that introduce a new matter potential sourced by electrons and neutrons, potentially impacting neutrino flavor oscillations. We revisit, revamp, and improve the constraints on these interactions that can be placed via the flavor composition of the diffuse flux of high-energy astrophysical neutrinos, with TeV–PeV energies, i.e., the proportion ofνe,νμ, andντin the flux. Because we consider mediators of these new interactions to be ultra-light, lighter than 10−10eV, the interaction range is ultra-long, from km to Gpc, allowing vast numbers of electrons and neutrons in celestial bodies and the cosmological matter distribution to contribute to this new potential. We leverage the present-day and future sensitivity of high-energy neutrino telescopes and of oscillation experiments to estimate the constraints that could be placed on the coupling strength of these interactions. We find that, already today, the IceCube neutrino telescope demonstrates potential to constrain flavor-dependent long-range interactions significantly better than existing constraints, motivating further analysis. We also estimate the improvement in the sensitivity due to the next-generation neutrino telescopes such as IceCube-Gen2, Baikal-GVD, KM3NeT, P-ONE, and TAMBO.
The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
Authors: Tian Yuan , Milic Jelena , Monasor Laura Sebastián , Chakraborty Rahul , Wang Sijia , Yuan Yue , Asare Yaw , Behrends Christian , Tahirovic Sabina , Bernhagen Jürgen 
Published: August 2023

AbstractThe constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus the levels of key cellular proteins. While the CSN and its catalytic subunit CSN5 have been extensively studied in cancer, its role in inflammatory and neurological diseases is less understood. Following verification that CSN5 is expressed in mouse and human brain, here we studied the role of the CSN in neuroinflammation and ischemic neuronal damage employing models of relevant brain-resident cell types, an ex vivo organotypic brain slice culture model, and the CRL NEDDylation state-modifying drugs MLN4924 and CSN5i-3, which mimic and inhibit, respectively, CSN5 deNEDDylase activity. Untargeted mass spectrometry-based proteomics revealed that MLN4924 and CSN5i-3 substantially alter the microglial proteome, including inflammation-related proteins. Applying these drugs and mimicking microglial and endothelial inflammation as well as ischemic neuronal stress by TNF and oxygen-glucose-deprivation/reoxygenation (OGD/RO) treatment, respectively, we could link CSN5/CSN-mediated cullin deNEDDylation to reduction of microglial inflammation, attenuated cerebral endothelial inflammation, improved barrier integrity, as well as protection from ischemic stress-induced neuronal cell death. Specifically, MLN4924 reduced phagocytic activity, motility, and inflammatory cytokine expression of microglial cells, and this was linked to inhibition of inflammation-induced NF-κB and Akt signaling. Inversely, Csn5 knockdown and CSN5i-3 increased NF-κB signaling. Moreover, MLN4924 abrogated TNF-induced NF-κB signaling in cerebral microvascular endothelial cells (hCMECs) and rescued hCMEC monolayers from OGD/RO-triggered barrier leakage, while CSN5i-3 exacerbated permeability. In an ex vivo organotypic brain slice model of ischemia/reperfusion stress, MLN4924 protected from neuronal death, while CSN5i-3 impaired neuronal survival. Neuronal damage was attributable to microglial activation and inflammatory cytokines, as indicated by microglial shape tracking and TNF-blocking experiments. Our results indicate a protective role of the CSN in neuroinflammation via brain-resident cell types involved in ischemic brain disease and implicate CSN activity-mimicking deNEDDylating drugs as potential therapeutics.
Topological Ordered Rings and Measures
Authors: García-Pacheco Francisco Javier , Moreno-Frías M. A. , Murillo-Arcila Marina 
Published: August 2023

AbstractGiven a ring endowed with a ring order, we provide sufficient conditions for the order topology induced by the ring order to become a ring topology (analogous results for module orders are consequently derived). Finally, the notions of Radon and regular measures are transported to the scope of module-valued measures through module orders. Classical characterizations of these measures are obtained as well as the hereditariness of regularity for conditional ring-valued measures.
On Non-linear Mappings Preserving the Semi-inner Product
Authors: Kobos Tomasz , Wójcik Paweł 
Published: August 2023

AbstractWe say that a smooth normed space X has a property (SL), if every mapping $$f:X \rightarrow X$$

f
:
X
→
X

preserving the semi-inner product on X is linear. It is well known that every Hilbert space has the property (SL) and the same is true for every finite-dimensional smooth normed space. In this paper, we establish several new results concerning the property (SL). We give a simple example of a smooth and strictly convex Banach space which is isomorphic to the space $$\ell _p$$

ℓ
p

, but without the property (SL). Moreover, we provide a characterization of the property (SL) in the class of reflexive smooth Banach spaces in terms of subspaces of quotient spaces. As a consequence, we prove that the space $$\ell _p$$

ℓ
p

have the property (SL) for every $$1< p < \infty $$

1
<
p
<
∞

. Finally, using a variant of the Gowers–Maurey space, we construct an infinite-dimensional uniformly smooth Banach space X such that every smooth Banach space isomorphic to X has the property (SL).
Incretins and microvascular complications of diabetes: neuropathy, nephropathy, retinopathy and microangiopathy
Authors: Goldney Jonathan , Sargeant Jack A. , Davies Melanie J. 
Published: August 2023

AbstractGlucagon-like peptide-1 receptor agonists (GLP-1RAs, incretin mimetics) and dipeptidyl peptidase-4 inhibitors (DPP-4is, incretin enhancers) are glucose-lowering therapies with proven cardiovascular safety, but their effect on microvascular disease is not fully understood. Both therapies increase GLP-1 receptor agonism, which is associated with attenuation of numerous pathological processes that may lead to microvascular benefits, including decreased reactive oxygen species (ROS) production, decreased inflammation and improved vascular function. DPP-4is also increase stromal cell-derived factor-1 (SDF-1), which is associated with neovascularisation and tissue repair. Rodent studies demonstrate several benefits of these agents in the prevention or reversal of nephropathy, retinopathy and neuropathy, but evidence from human populations is less clear. For nephropathy risk in human clinical trials, meta-analyses demonstrate that GLP-1RAs reduce the risk of a composite renal outcome (doubling of serum creatinine, eGFR reduction of 30%, end-stage renal disease or renal death), whereas the benefits of DPP-4is appear to be limited to reductions in the risk of albuminuria. The relationship between GLP-1RAs and retinopathy is less clear. Many large trials and meta-analyses show no effect, but an observed increase in the risk of retinopathy complications with semaglutide therapy (a GLP-1RA) in the SUSTAIN-6 trial warrants caution, particularly in individuals with baseline retinopathy. Similarly, DPP-4is are associated with increased retinopathy risk in both trials and meta-analysis. The association between GLP-1RAs and peripheral neuropathy is unclear due to little trial evidence. For DPP-4is, one trial and several observational studies show a reduced risk of peripheral neuropathy, with others reporting no effect. Evidence in other less-established microvascular outcomes, such as microvascular angina, cerebral small vessel disease, skeletal muscle microvascular disease and autonomic neuropathies (e.g. cardiac autonomic neuropathy, gastroparesis, erectile dysfunction), is sparse. In conclusion, GLP-1RAs are protective against nephropathy, whereas DPP-4is are protective against albuminuria and potentially peripheral neuropathy. Caution is advised with DPP-4is and semaglutide, particularly for patients with background retinopathy, due to increased risk of retinopathy. Well-designed trials powered for microvascular outcomes are needed to clarify associations of incretin therapies and microvascular diseases.
Graphical Abstract
Robust tool condition monitoring in Ti6Al4V milling based on specific force coefficients and growing self-organizing maps
Authors: Bernini Luca , Albertelli Paolo , Monno Michele 
Published: August 2023

AbstractTool condition monitoring (TCM) is a mean to optimize production systems trying to use cutting tool life at its best. Nevertheless, nowadays available TCM algorithms typically lack robustness in order to be consistently applied in industrial scenarios. In this paper, an unsupervised artificial intelligence technique, based on Growing Self-Organizing Maps (GSOM), is presented in synergy with real-time specific force coefficients (SFC) estimation through the regression of instantaneous cutting forces. The conceived approach allows robustly mapping the SFC, exploiting process parameters and similarity to manage the variability of their estimation due to unmodelled phenomena, like machine dynamics and tool run-out. The devised approach allowed detecting the tool end-of-life in cutting tests with variable lubrication, machine tool and cutting speed, through the adoption of a self-starting control chart running on real-time clustered data. The solution was validated through the comparison of the GSOM framework with respect to the optimized self-starting control chart applied without GSOM clustering. The GSOM reached a root mean squared percentage error (RMSPE) of 13.2% with respect to 56.1% obtained with the analogous control chart in a full-set optimization scenario. When optimised on tests for a unique machine tool and tested on another machine tool, GSOM scored an RMSPE of 34.5%, whereas the optimized control chart scored 64.5%.
Prediction of protein denaturation and weight loss in pork loin (muscle Longissimus dorsi) using computational fluid dynamics
Authors: Szpicer Arkadiusz , Binkowska Weronika , Wojtasik-Kalinowska Iwona , Poltorak Andrzej 
Published: August 2023

AbstractThe article proposes using Computational Fluid Dynamics to predict protein denaturation and weight loss in pork loin samples during baking. The optimal conditions of heat treatment were determined to be at 181.55℃, 20% humidity, and a fan speed of 639.18 rpm. Following this process, the denaturation of various pork loin proteins was measured, and the weight loss was determined to be 12.21 ± 0.89%. In the laboratory study at the verification stage, it was found that myosin and actin denaturation and body weight loss did not differ significantly from the values predicted on the basis of the response surface model developed using simulation data. However, the degree of sarcoplasmic protein denaturation observed in the laboratory was lower than the model's predictions, while collagen denaturation was higher. The study suggests that computational fluid dynamics can be a useful tool for predicting protein denaturation and weight loss in pork loin samples and could improve product quality and consistency in the food industry.
Early-Onset Fetal Growth Restriction Increases Left Ventricular Sphericity in Adolescents Born Very Preterm
Authors: Liefke Jonas , Sepúlveda-Martinez Alvaro , Shakya Snehlata , Ehrenborg Katarina Steding , Arheden Håkan , Morsing Eva , Ley David , Heiberg Einar , Hedström Erik 
Published: August 2023

AbstractLeft ventricular shape alterations predict cardiovascular outcomes and have been observed in children born preterm and after fetal growth restriction (FGR). The aim was to investigate whether left ventricular shape is altered in adolescents born very preterm and if FGR has an additive effect. Adolescents born very preterm due to verified early-onset FGR and two control groups with birthweight appropriate for gestational age (AGA), born at similar gestational age and at term, respectively, underwent cardiac MRI. Principal component analysis was applied to find the modes of variation best explaining shape variability for end-diastole, end-systole, and for the combination of both, the latter indicative of function. Seventy adolescents were included (13–16 years; 49% males). Sphericity was increased for preterm FGR versus term AGA for end-diastole (36[0–60] vs − 42[− 82–8]; p = 0.01) and the combined analysis (27[− 23–94] vs − 51[− 119–11]; p = 0.01), as well as for preterm AGA versus term AGA for end-diastole (30[− 56–115] vs − 42[− 82–8]; p = 0.04), for end-systole (57[− 29–89] vs − 30[− 79–34]; p = 0.03), and the combined analysis (44[− 50–145] vs − 51[− 119–11]; p = 0.02). No group differences were observed for left ventricular mass or ejection fraction (all p ≥ 0.33). Sphericity was increased after very preterm birth and exacerbated by early-onset FGR, indicating an additive effect to that of very preterm birth on left ventricular remodeling. Increased sphericity may be a prognostic biomarker of future cardiovascular disease in this cohort that as of yet shows no signs of cardiac dysfunction using standard clinical measurements.
Establishment of an indirect ELISA for Mycobacterium tuberculosis MTB39A protein antibody
Authors: Wang Pu , Cai Yurong , Zhang Gang , Jiang Lingling , Li Yong 
Published: August 2023

Abstract
The MTB39A protein is a member of the unique Mycobacterium tuberculosis (MTB) PE/PPE protein family and is the main candidate for tuberculosis (TB) diagnosis. The aim of this study was to establish a novel indirect ELISA (iELISA) method that uses antibodies against MTB. The MTB39A gene sequence was synthesized according to the MTB39A nucleotide sequence of the MTB H37Rv strain (GenBank accession number: NC_000962.3) and cloned into the pET28a( +) vector. After correct sequencing, it was transferred to Escherichia coli BL21 (DE3) receptor cells for expression and purification, and the purified recombinant protein was identified by SDS-PAGE and western blotting. The purified MTB39A protein was used as the capture antibody, and a rabbit polyclonal antibody against the MTB MTB39A protein was used as the detection antibody to establish an indirect ELISA method. The ELISA conditions were optimized, and the optimal coating concentration of the MTB39A antigen was determined to be 0.5 μg/mL. The optimal dilution of MTB39A rabbit polyclonal antibody was 1:4096, and the optimal dilution of HRP-goat anti-rabbit IgG was 1:4000. The results showed that this indirect ELISA method has high sensitivity, specificity and efficacy for MTB39A protein detection. Moreover, this indirect ELISA method has optimal stability and can be used for the initial detection of MTB antibodies in clinical human and bovine serum samples. The establishment of this assay provides a new method for the rapid diagnosis of MTB and technical support for the prevention and control of tuberculosis.

Key points
• MTB MTB39A protein was expressed in a prokaryotic expression system.
• Rabbit polyclonal antibody against MTB39A was prepared.
• To establish an iELISA based on the MTB39A protein for the detection of MTB antibodies.
Simple method for determining quantum efficiency and background propagation loss in thulium-doped fibres
Authors: Buckthorpe Martin P. , Clarkson W. Andrew 
Published: August 2023

AbstractA method for determining the quantum efficiency and background propagation loss in rare earth-doped silica fibres is presented. These parameters can be determined using straightforward measurements of slope efficiency and emission spectra at various lengths of active fibre. This method has been applied to a thulium-doped silica fibre with a structured ‘nested-ring’ doping profile. The quantum efficiency of this fibre was 1.93 ± 0.01 and the background propagation loss was 0.15 ± 0.01 dB/m. This characterisation method also allows the relative impact of these parameters on the slope efficiency of an all-fibre high-power system to be predicted. It was found that the non-ideal background propagation loss of this fibre results in a decrease of $$\sim $$
∼
18 percentage points on the predicted slope efficiency, whereas the quantum efficiency results in a decrease of $$\sim $$
∼
3 percentage points. The predicted slope efficiency with respect to absorbed pump power of 62 ± 2% for the all-fibre high-power system is consistent with the experimental result of 61.5%. This characterisation provides feedback to the fibre design and fabrication that for efficient power scaling, efforts to decrease the background propagation loss of this fibre can provide a greater increase in efficiency than efforts to further increase the quantum efficiency.
Societal costs of personality disorders among treatment-seeking patients in Norway: the relative contribution of specific DSM-5 categories
Authors: Sveen C. A. , Pedersen G. , Ulvestad D. A. , Zahl K. E. , Wilberg T. , Kvarstein E. H. 
Published: August 2023

AbstractPersonality disorders (PDs) are associated with high levels of societal costs, regardless of whether a single PD or a broad range of PDs have been studied. However, research on the relative contribution of specific PD-types on societal costs is limited. The aim of this study was to explore the possible contributions of the individual DSM-5 categories of PDs on the level of societal costs and its components (health service costs and productivity loss), while controlling for the impact of comorbid mental health and substance use disorders on these outcomes. Participants (n = 798) were retrieved from the quality register of the Norwegian Network for Personality Disorders—a collaboration of PD-treatment units within specialist mental health services. The patients were referred to treatment in the time-period 2017–2020. Costs were assessed using a structured interview covering the 6-month period prior to assessment. Diagnoses were determined by semi-structured diagnostic interviews (SCID-5-PD and M.I.N.I.). Statistics included multiple regression analyses. The main result was that no specific PD had a unique contribution to the high level of societal costs generally found among treatment-seeking patients with PDs. Borderline PD (BPD) was the only PD with significantly higher health service costs than the other PDs, while BPD, avoidant PD, and unspecified PD were independently associated with enhanced productivity loss. The differential cost-effects of specific PDs on the cost components were small. Several comorbid mental health and substance use disorders were significant contributors to costs, irrespective of PD status. The results underscore the importance of developing and implementing effective treatments for a broader range of PDs, to reduce the high levels of societal costs associated with all PDs.