bluuebunny/crossref_metadata_2025_split huggingface dataset:
The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in atrophic AMD
Authors: Ghosh Sayan , Sharma Ruchi , Bammidi Sridhar , Koontz Victoria , Nemani Mihir , Yazdankhah Meysam , Kedziora Katarzyna M. , Wallace Callen T. , Yu-Wei Cheng , Franks Jonathan , Bose Devika , Rajasundaram Dhivyaa , Hose Stacey , Sahel José-Alain , Puertollano Rosa , Finkel Toren , Zigler J. Samuel , Sergeev Yuri , Watkins Simon C. , Goetzman Eric S. , Flores-Bellver Miguel , Kaarniranta Kai , Sodhi Akrit , Bharti Kapil , Handa James T. , Sinha Debasish 
Published: August 2023

Introductory paragraphAge-related macular degeneration (AMD), the leading cause of geriatric blindness, is a multi-factorial disease with retinal-pigmented epithelial (RPE) cell dysfunction as a central pathogenic driver. With RPE degeneration, lysosomal function is a core process that is disrupted. Transcription factors EB/E3 (TFEB/E3) tightly control lysosomal function; their disruption can cause aging disorders, such as AMD. Here, we show that induced pluripotent stem cells (iPSC)-derived RPE cells with the complement factor H variant [CFH(Y402H)] have increased AKT2, which impairs TFEB/TFE3 nuclear translocation and lysosomal function. Increased AKT2 can inhibit PGC1α, which downregulates SIRT5, an AKT2 binding partner. SIRT5 and AKT2 co-regulate each other, thereby modulating TFEB-dependent lysosomal function in the RPE. Failure of the AKT2/SIRT5/TFEB pathway in the RPE induced abnormalities in the autophagy-lysosome cellular axis by upregulating secretory autophagy, thereby releasing a plethora of factors that likely contribute to drusen formation, a hallmark of AMD. Finally, overexpressing AKT2 in RPE cells in mice led to an AMD-like phenotype. Thus, targeting the AKT2/SIRT5/TFEB pathway could be a potential therapy for atrophic AMD.
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
Authors: Laguna Ariadna , Peñuelas Núria , Gonzalez-Sepulveda Marta , Nicolau Alba , Arthaud Sébastien , Guillard-Sirieix Camille , Lorente-Picón Marina , Compte Joan , Miquel-Rio Lluís , Xicoy Helena , Liu Jiong , Parent Annabelle , Cuadros Thais , Romero-Giménez Jordi , Pujol Gemma , Giménez-Llort Lydia , Fort Patrice , Bortolozzi Analia , Carballo-Carbajal Iria , Vila Miquel 
Published: August 2023

ABSTRACTOne key limitation in developing effective treatments for neurodegenerative diseases is the lack of models accurately mimicking the complex physiopathology of the human disease. Humans accumulate with age the pigment neuromelanin inside neurons that synthesize catecholamines. Neurons reaching the highest neuromelanin levels preferentially degenerate in Parkinson’s, Alzheimer’s and apparently healthy aging individuals. However, this brain pigment is not taken into consideration in current animal models because common laboratory species, such as rodents, do not produce neuromelanin. Here we generate a tissue-specific transgenic mouse, termed tgNM, that mimics the human age-dependent brain-wide distribution of neuromelanin within catecholaminergic regions, based on the constitutive catecholamine-specific expression of human melanin-producing enzyme tyrosinase. We show that, in parallel to progressive human-like neuromelanin pigmentation, these animals display age-related neuronal dysfunction and degeneration affecting numerous brain circuits and body tissues, linked to motor and non-motor deficits, reminiscent of early neurodegenerative stages. This model may open new research avenues in brain aging and neurodegeneration.
Asymmetric tethering by exocystin vitrorequires a Rab GTPase, a v-SNARE and a Sac1-sensitive phosphoinositide lipid
Authors: Rossi Guendalina , Puller Gabrielle C. , Brennwald Patrick 
Published: August 2023

AbstractTethering factors play a critical role in deciphering the correct combination of vesicle and target membrane for subsequent fusion. The exocyst plays a central role in tethering post-Golgi vesicles to the plasma membrane, although the mechanism by which this occurs is poorly understood. We recently established an assay for measuring exocyst-mediated vesicle tetheringin vitroand we have adapted this assay to examine the ability of exocyst to tether vesicles in an asymmetric fashion. We demonstrate that exocyst differs from another post-Golgi vesicle tethering protein, Sro7, in that it is fully capable of tethering vesicles with functional Rab GTPase, Sec4, to vesicles lacking a functional Rab GTPase. Using this assay, we show that exocyst requires both the Rab and R-SNARE, Snc1, to be present on the same membrane surface. In contrast, using Sac1 phosphatase treatment, we demonstrate a likely role for phosphoinositides on the opposing Rab-deficient membrane. This suggests a specific model for exocyst orientation and its points of contact between membranes during heterotypic tethering of post-Golgi vesicles with the plasma membrane.
Prescription opioids, consumption cultures and “informal governing images” among “young street guys” in Nigeria
Authors: Onyima Blessing Nonye 
Published: August 2023

Purpose
This paper aims to explore the misuse of prescription opioids, associated consumption cultures and the emergence of “informal governing images” among young men in Nigeria.

Design/methodology/approach
Using a qualitative research approach involving purposive sampling: six in-depth interviews, one focus group discussion and key informant interviews with two health-care professionals using the transgressive theory approach, this paper explores consumption cultures, motivations and the resultant “informal governing images” associated with the misuse of prescription opioids among young local street high-risk users in Nigeria.

Findings
Findings show complex expressions of diverse consumption practices, such as grinding, sniffing and concoction of tramadol (TM)with other opioids. The “puff-puff pass” practice serves as induction for new users of opioids commonly accessed through street drug dealers and pharmacists sold via backdoors. Codeine mixtures with different brands of soft drinks for dilution are used to achieve a “lower high” while a concoction of different opioids, with alcohol, and spirits obtains a “higher high”. Manufacturers’ indelible colouring and bottling discourage the non-medical use of opioids. Desiring to be awake for nocturnal activities, mostly “yahoo-yahoo” (internet fraud), sexual enhancement and dosage competitions, are motivations for the non-medical use of prescription opioids. These consumption cultures create “misuse circuits”, leading to the emergence of “informal governing images” triggered by threats from formal controls.

Practical implications
This paper, therefore, concludes that pharmaceutical industries should also add colourings to TM and codeine just like they did in rophinol to discourage the non-medical use of prescription opioids among young people in Nigeria.

Social implications
This paper concludes that rather than branding and packaging in such a way that concealability is difficult for high-risk users as the best way to discourage the non-medical consumption of prescription opioids in Nigeria, the focus should be on addressing youth poverty and unemployment and improving access to treatment for drug use disorders, instead of calling for more enforcement-based measures.

Originality/value
This is an original research.
Do financial constraints affect the CEO stock options remuneration? Evidence from a panel threshold model
Authors: Zaiane Sedki , Dabbou Halim , Gallali Mohamed Imen 
Published: August 2023

PurposeThe purpose of this study is to examine the nonlinear relationship between financial constraints and the chief executive officer (CEO) stock options compensation and to analyze whether the impact of financial constraints on the CEO stock options compensation changes at certain level of financial constraints or not.Design/methodology/approachThis study is based on a sample of 90 French firms for the period extending from 2008 to 2019. To deal with the non-linearity, the authors use a panel threshold method.FindingsUsing different measures of financial constraints [KZ index (Baker et al., 2003), SA index (Hadlock and Pierce, 2010) and FCP index (Schauer et al., 2019)], the results reveal that the impact of the financial constraints (SA index and FCP index) is positive below the threshold value and it becomes negative above.Research limitations/implicationsThe non-linearity between financial constraints and CEO stock options shows that the level of financial constraints can be a major determinant of the CEO compensation structure. More specifically, this study sheds light on the key role played by the level of financial constraints and how this latter influence management decisions.Originality/valueThis paper is the first to the best of the authors' knowledge to examine the nonlinear relationship between financial constraints and the CEO stock options compensation using a panel threshold model.
Validation of a scale for the perception of competences and attitudes in the context of public administration
Authors: Moreira Ana , Nishimura Adriana , Sousa Maria José , Au-Yong-Oliveira Manuel 
Published: August 2023

Purpose
This study aims at validating a scale for the perception of competences and attitudes of the Portuguese public administration employees. The sample of this study consists of 1,119 participants working in public administration and other labour sectors in Portugal. The psychometric qualities of this instrument were studied to assess its use in future studies.

Design/methodology/approach
An initial exploratory factor analysis showed that the scale is composed of one factor, with a Kaiser–Meyer–Oklin value of 0.83. The subsequent confirmatory factor analysis performed in AMOS 27 confirmed the existence of a single factor.

Findings
The analysis of the psychometric qualities of the scale allows concluding that it can be applied in the context of the Portuguese public administration.

Originality/value
Given the universality of the competences and attitudes adopted, it can be extended to other work and cultural contexts.
The more the merrier the wealthier? Multi-dimensional taxonomy of demography and development in Indonesia
Authors: Wardhana Dharendra 
Published: August 2023

Purpose
This paper aims to unpack the nexus of development and demography controlling for three important variables to represent the meaning of development, that is, poverty rate, unemployment rate and human development index (HDI). Demographic variables are proxied with total fertility rate (TFR) and net migration rate (NMR).

Design/methodology/approach
This research applies cluster analysis at the provincial level using INDO-DAPOER and 2015 Intercensal Population Survey data sets.

Findings
Demographic and development status of Indonesian provinces can be classified into four clusters, and members of these clusters are mostly dissimilar with those of previous groupings on demographic dividends (Adioetomo, 2018). With only less than 50% matching rate, the author argues that there is no simple linear relationship between demographic and development variables.

Research limitations/implications
The most recent data set on Population Census Year 2020 has not been made available at the time of the writing. Also sometimes known as unsupervised classification, cluster analysis is about finding groups in a set of objects characterised only by certain measurements; therefore, findings of this study need to be positioned solely within the context of development and demography.

Practical implications
Taxonomy in this study offers a more nuanced and contextual understanding of the diverse challenges at the local and regional levels. Recommendations from this study lead to asymmetrical design in development policies and budget proportions at local levels.

Social implications
It is expected that the findings are relevant to the input of policymaking process within the sphere of development and demography, especially for countries with significant size of populations and grappling with development issues.

Originality/value
To the author’s understanding, this paper is the first to discuss the impact of “demographic dividend” to economic development in Indonesia using the approach of cluster analysis. The expected contribution of this work is twofold: Firstly, the author would like to ignite a discourse on the nexus of development and demography using the most recent data set and cutting-edge method. Secondly, the findings are relevant to the input of policymaking process within the sphere of development and demography, especially for countries with significant size of populations and grappling with development issues.
Prospects of augmented reality and virtual reality for online education: a scientometric view
Authors: Tiwari Chandan Kumar , Bhaskar Preeti , Pal Abhinav 
Published: August 2023

PurposeAugmented reality (AR) and virtual reality (VR) are becoming increasingly interwoven into people's daily lives, with applications in fields such as science, engineering, medical, the arts, education, finance and business. While much study has been conducted in the field of VR and AR in a variety of areas, less attention has been paid to online education. The purpose of this research is to conduct a systematic review of studies on AR and VR, as well as its applications in many disciplines of education, with a special emphasis on online education.Design/methodology/approachThe data were gathered from the SCOPUS database under the subject “Augmented and Virtual Reality Applications in Online Education.” The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) format has been used to summarize the available literature and research in academics throughout the world. First, systematic literature reviews and later bibliometric analysis were conducted for performance and science mapping analysis.FindingsThe research adds to the body of knowledge about the role of AR and VR in online education and its future prospects. AR and VR have demonstrated a substantial contribution to facilitating teaching in a variety of fields, including engineering, medicine, nursing and chemistry. Additionally, this research indicates that AR and VR can be utilized to teach various areas and specialties. Additionally, it can be used in other aspects of online education, such as admissions, industry visits, training, internationalization and specific courses for students with disabilities.Practical implicationsThis research lays the framework for educational institutions, legislators and researchers to investigate additional applications of VR and AR. Though this research suggests some possible uses for AR and VR in the online education system, more applications can be integrated into the online education system to fully leverage the potential of AR and VR worldwide. AR and VR have the potential to be a very cost-effective method of delivering online education on a wide scale in the future.Originality/valueThe article explores the applicability of VR and AR in education using bibliometric analysis. This is one of the first studies to do an assessment of VR and AR, evaluating their strengths, drawbacks and current applications. Future application areas are also identified as a result of the investigation.
Use and acceptance of crypto currencies in India: an evaluation of block chain application in financial sector using PLS SEM and ANN approach
Authors: Mishra Niraj , Srivastava Praveen , Mahato Satyajit , Shivani Shradha 
Published: August 2023

PurposeThis paper aims to create and evaluate a model for cryptocurrency adoption by investigating how age, education, and gender impact Behavioural Intention. A hybrid approach that combined partial least squares structural equation modeling (PLS-SEM) and artificial neural network (ANN) was used for the purpose.Design/methodology/approachThis study uses a multi-analytical hybrid approach, combining PLS-SEM and ANN to illustrate the impact of various identified variables on behavioral intention toward using cryptocurrency. Multi-group analysis (MGA) is applied to determine whether different data groups of age, gender and education have significant differences in the parameter estimates that are specific to each group.FindingsThe findings indicate that Social Influence (SI) has the greatest impact on Behavioral Intention (BI), which suggests that the viewpoints and recommendations of influential and well-known individuals can serve as a motivating factor to invest in cryptocurrencies. Furthermore, education was found to be a moderating factor in the relationship found between behavioral intention and design.Research limitations/implicationsPrior studies on technology adoption have utilized superficial SEM and ANN methods, whereas a more effective outcome has been suggested by implementing a dual-stage PLS-SEM and ANN approach utilizing a deep neural network architecture. This methodology can enhance the accuracy of nonlinear connections in the model and augment the deep learning capacity.Practical implicationsThe research is based on the Unified Theory of Acceptance and Use of Technology (UTAUT2) and expands upon this model by integrating elements of design and trust. This is an important addition, as design can influence individuals' willingness to try new technologies, while trust is a critical factor in determining whether individuals will adopt and use new technology.Social implicationsCryptocurrencies are a relatively new phenomenon in India, and their use and adoption have grown significantly in recent years. However, this development has not been without controversy, as the implications of cryptocurrencies for society, the economy and governance remain uncertain. The results reveal that social influence is an important predictor for the adoption of cryptocurrency in India, and this can help financial institutions and regulators in making policy decisions accordingly.Originality/valueGiven the emerging nature of cryptocurrency adoption in India, there is certainly a need for further empirical research in this area. The current study aims to address this research gap and achieve the following objectives: (a) to determine if a dual-stage PLS-SEM and ANN analysis utilizing deep learning techniques can yield more comprehensive research findings than a PLS-SEM approach and (b) to identify variables that can forecast the intention to adopt cryptocurrency.
Street-level netocracy: rules, discretion and professionalism in a network-based intervention
Authors: Da Roit Barbara , Busacca Maurizio 
Published: August 2023

PurposeThe paper aims to analyse the meaning and extension of discretionary power of social service professionals within network-based interventions.Design/methodology/approachEmpirically, the paper is based on a case study of a network-based policy involving private and public organisations in the Northeast of Italy (Province of Trento).FindingsThe paper identifies netocracy as a social policy logic distinct from bureaucracy and professionalism. What legitimises netocracy is neither authority nor expertise but cooperation, the activation of connections and involvement, considered “good” per se. In this framework, professionalism and discretion acquire new and problematic meanings compared to street-level bureaucracy processes.Research limitations/implicationsBased on a case study, the research results cannot be generalised but pave the way to further comparative investigations.Practical implicationsThe paper reveals that the position of professionals in netocracy is to some extent trickier than that in a bureaucracy because netocracy seems to have the power to encapsulate them and make it less likely for them to deviate from expected courses of action.Originality/valueCombining different literature streams – street level bureaucracy, professionalism, network organisations and welfare governance – and building on an original case study, the paper contribute to understanding professionalism in welfare contexts increasingly characterised by the combination of bureaucratic, professional and network logics.
The impact of enterprise social media usage on employee creativity: a self-regulation perspective
Authors: Deng Manting , Zhu Jiantao 
Published: August 2023

PurposeOrganizations have widely adopted enterprise social media (ESM) to improve employees' creativity. This study applies self-regulation theory to explore the role of feedback seeking in mediating the effects of work-oriented and social-oriented ESM usage on employee creativity.Design/methodology/approachA questionnaire was conducted on 219 working professionals in China – professionals that use ESM in respective organizations.FindingsResults show that both work-oriented and social-oriented ESM usage are positively associated with employee feedback inquiry and, subsequently, increased employee creativity. The findings also suggest that social-oriented ESM usage is positively related to employee monitoring, whereas employee feedback monitoring is not related to employee creativity.Research limitations/implicationsPractitioners and/or managers need to pay greater attention to the impact of work-oriented and social-oriented ESM usage on employee feedback seeking strategies and creativity. The low response rate is one of the limitations in this study, although the results of the test suggest that non-response bias is not a critical issue in this study.Originality/valueThis study contributes to the knowledge of feedback inquiry in explaining the effect of work-oriented and social-oriented ESM usage on employee creativity. The current study helps to extend the intervening mechanism in the relationship between ESM usage and employee creativity.
Financial disclosure manipulation: a virtue ethics perspective
Authors: Demaline Christopher J. 
Published: August 2023

Purpose
Financial disclosure manipulation is unethical and unlawful because it leads to less transparent reporting and harmful economic decisions based on misleading information. The purpose of this paper is to provide a summary and synthesis of research covering financial disclosure misrepresentation via impression management (IM). Ultimately, this report proposes that virtuous managers may be well-suited to provide transparent, objective disclosure. By extension, virtuous managers may oversee profitable firms and improve capital market efficiency. Suggestions for future research are presented.

Design/methodology/approach
This is an academic literature review covering financial disclosure manipulation. The findings are viewed through the lens of Christian virtue ethics (CVE).

Findings
IM studies commonly focus on specific methods used to mislead disclosure readers. Antecedent and mitigation strategies are less commonly noted in the research. This paper presents and analyzes IM tools and antecedents. Mitigation approaches are considered through the lens of CVE. This report proposes that virtuous managers may be well-suited to provide transparent, objective disclosure. By extension, virtuous managers may oversee profitable firms and improve capital market efficiency.

Originality/value
This present study focuses on the antecedents of IM in financial disclosures and introduces a novel perspective to financial disclosure mitigation – CVE. Financial disclosure authors and readers, researchers, financial regulators and accounting standards setters may be interested in the findings presented in this study.