bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biobehavioral Interactions between Endocannabinoid and Hypothalamicpituitary-
adrenal Systems in Psychosis: A Systematic Review
Authors: Colizzi Marco , Bortoletto Riccardo , Antolini Giulia , Bhattacharyya Sagnik , Balestrieri Matteo , Solmi Marco 
Published: August 2023

Background:
The diathesis-stress paradigm and the cannabinoid-hypothesis have been proposed
as possible pathophysiological models of schizophrenia. However, they have historically been
studied independently of each other.

Objective:
This PRISMA 2020-compliant systematic review aimed at reappraising the interplay between
the hypothalamic-pituitary-adrenal (HPA) axis and the endocannabinoid (eCB) system in psychosis-
spectrum disorder risk and outcome.

Methods:
All pathophysiological and outcome clinical studies, concomitantly evaluating the two systems
in psychosis-spectrum disorder risk and different stages of illness, were gathered from electronic
databases (Pubmed, Web of Science, and Scopus), and discussed.

Results:
41 eligible outputs were extracted, focusing on at least a biological measure (9 HPA-related
studies: 4 eCB-interventional, 1 HPA-interventional, 1 both HPA-interventional and non-interventional, 3
non-interventional; 2 eCB-related studies: non-interventional), environmental measures only (29 studies:
1 eCB- interventional, 28 non-interventional), and genetic measures (1 study: non-interventional). Independent
contributions of aberrancies in the two systems to the physiopathology and outcome of psychosis
were confirmed. Also, concomitant alterations in the two systems, either genetically defined
(e.g., CNR1 genetic variation), biologically determined (e.g., dysfunctional HPA axis or endocannabinoid
signaling), or behaviorally imputed (e.g., cannabis use, stress exposure, and response), were
consistently reported in psychosis. Further, a complex biobehavioral perturbation was revealed not only
within each system (e.g., cannabis use affecting the eCB tone, stress exposure affecting the HPA axis),
but also across the two systems (e.g., THC affecting the HPA axis, childhood trauma affecting the
endocannabinoid signaling).

Conclusion:
There is a need to concomitantly study the two systems’ mechanistic contribution to psychosis
in order to establish more refined biological relevance.
Natural STAT3 Inhibitors for Cancer Treatment: A Comprehensive
Literature Review
Authors: Zarezadeh Seyed Mahdi , Sharafi Amir Mohammad , Erabi Gisou , Tabashiri Arefeh , Teymouri Navid , Mehrabi Hoda , Golzan Seyyed Amirhossein , Faridzadeh Arezoo , Abdollahifar Zahra , Sami Nafiseh , Arabpour Javad , Rahimi Zahra , Ansari Arina , Abbasi Mohammad Reza , Azizi Nima , Tamimi Amirhossein , Poudineh Mohadeseh , Deravi Niloofar 
Published: August 2023

Abstract:
Cancer is one of the leading causes of mortality and morbidity worldwide, affecting
millions of people physically and financially every year. Over time, many anticancer treatments
have been proposed and studied, including synthetic compound consumption, surgical procedures,
or grueling chemotherapy. Although these treatments have improved the daily life quality of patients
and increased their survival rate and life expectancy, they have also shown significant drawbacks,
including staggering costs, multiple side effects, and difficulty in compliance and adherence
to treatment. Therefore, natural compounds have been considered a possible key to overcoming
these problems in recent years, and thorough research has been done to assess their effectiveness.
In these studies, scientists have discovered a meaningful interaction between several
natural materials and signal transducer and activator of transcription 3 molecules. STAT3 is a
transcriptional protein that is vital for cell growth and survival. Mechanistic studies have established
that activated STAT3 can increase cancer cell proliferation and invasion while reducing
anticancer immunity. Thus, inhibiting STAT3 signaling by natural compounds has become one
of the favorite research topics and an attractive target for developing novel cancer treatments. In
the present article, we intend to comprehensively review the latest knowledge about the effects
of various organic compounds on inhibiting the STAT3 signaling pathway to cure different
cancer diseases.
Chronic Stress as a Risk Factor for Type 2 Diabetes: Endocrine, Metabolic,
and Immune Implications
Authors: Lisco Giuseppe , Giagulli Vito Angelo , De Pergola Giovanni , Guastamacchia Edoardo , Jirillo Emilio , Vitale Elsa , Triggiani Vincenzo 
Published: August 2023

Background:
Background: Chronic stress is a condition of pressure on the brain and whole body, which
in the long term may lead to a frank disease status, even including type 2 diabetes (T2D). Stress
activates the hypothalamus-pituitary-adrenal axis with release of glucocorticoids (GCs) and catecholamines,
as well as activation of the inflammatory pathway of the immune system, which alters glucose
and lipid metabolism, ultimately leading to beta-cell destruction, insulin resistance and T2D
onset. Alteration of the glucose and lipid metabolism accounts for insulin resistance and T2D outcome.
Furthermore, stress-related subversion of the intestinal microbiota leads to an imbalance of the
gut-brain-immune axis, as evidenced by the stress-related depression often associated with T2D.

:
A condition of generalized inflammation and subversion of the intestinal microbiota represents another
facet of stress-induced disease. In fact, chronic stress acts on the gut-brain axis with multiorgan
consequences, as evidenced by the association between depression and T2D.

:
Oxidative stress with the production of reactive oxygen species and cytokine-mediated inflammation
represents the main hallmarks of chronic stress. ROS production and pro-inflammatory cytokines
represent the main hallmarks of stress-related disorders, and therefore, the use of natural antioxidant
and anti-inflammatory substances (nutraceuticals) may offer an alternative therapeutic approach to
combat stress-related T2D. Single or combined administration of nutraceuticals would be very beneficial
in targeting the neuro-endocrine-immune axis, thus, regulating major pathways involved in
T2D onset. However, more clinical trials are needed to establish the effectiveness of nutraceutical
treatment, dosage, time of administration and the most favorable combinations of compounds. Therefore,
in view of their antioxidant and anti-inflammatory properties, the use of natural products or
nutraceuticals for the treatment of stress-related diseases, even including T2D, will be discussed.
Several evidences suggest that chronic stress represents one of the main factors responsible for the
outcome of T2D.
Premarital Cohabitation as a Model of Matrimonial Behavior of Young People
Authors: Kobleva Z. Kh. 
Published: August 2023

The relevance of the research topic is caused by the emergence of serious scientific interest in the study of value orientations in the system of traditional premarital behavior, characterized by the presence of destructive phenomena and the formation of a new model of premarital strategy of young people, which have a serious impact on value preferences and attitudes in the system of choosing forms of family and marriage relations.It was found that the traditional system of premarital behavior has undergone a significant transformation associated with increased interest on the part of young people in cohabitation during the premarital period, reflecting the obvious processes of individualization of values and significant changes in the system of behavioral models in the youth environment.The purpose of this article is due to the identification of the main social mechanisms that have a significant impact on the formation of premarital cohabitation among young people.Objectives: to consider the main values in the modern youth environment; to analyze the motives and identify the reasons for the formation of premarital cohabitation in the youth environment in the context of modern transformational processes.Methodology. In the course of work on the study, methods of systemic, structural and functional analysis were used, methods of comparison, observation, questioning and interviewing were used in the process of studying value orientations in the system of premarital behavior of young people.Results. The sociological research conducted within the framework of the problem posed allowed analyzing the features of the value preferences of young people in choosing the main marriage strategies in modern conditions; to determine the degree of influence of social factors on the functioning of the system of premarital behavior, which has undergone significant changes in modern conditions.Conclusions. The transformational processes affecting the institution of the family caused by the difficult socioeconomic conditions of life in Russian society, which had a significant impact on the formation of new value orientations and attitudes among young people, had a significant impact on the state of the system of traditional premarital behavior.
Employment of Graduates of Secondary Vocational and Higher Education Institutions of the Kursk Region in Conditions of Disproportion between the Educational Segment and the Labor Market
Authors: Abramov A. P. , Tatarenkova D. Yu. , Chuichenko V. D. 
Published: August 2023

Relevance. In modern conditions, when significant social and social changes are taking place, the problem of employment of graduates of institutions of secondary vocational and higher education is becoming important and needs fundamental changes in the field of employment. Due to the imbalance in the process of training specialists at all levels of education with the real needs of the labor market, there is periodically an oversaturation or shortage of certain professions. Consequently, there is a disproportion between supply and demand in the field of educational services, on the one hand, and the employment market, on the other. The purpose is to identify the causes and consequences of the imbalance of the educational sphere and the labor market and employment.Objectives: to characterize theoretical approaches to the analysis of the socio-economic nature of the labor market; to determine the value attitudes of young people in the professional and labor sphere; to identify the problems of employment of young professionals in the labor market of the Kursk region.Methodology. The study is based on concepts and theories that reveal the socio-cultural and socio-economic nature of the Russian labor market and employment. Methods of synthesis, comparison and analogy were applied, which made it possible, on the basis of specific empirical material, to determine the main problems of employment of graduates of institutions of secondary vocational and higher education in the Kursk region.Results. Educational institutions have a low orientation towards the training of qualified specialists. Communication employer (economic entity) - graduate (university) is in a state of imbalance and ultimately does not solve the problem of youth entering the labor market.Conclusions. The main difficulties in finding a decent job are the rather high requirements of the employer to the applicant and the lack of work experience in the chosen profession. The most significant factors in employment are wages, proximity of work to home and flexible employment schedule. It is not always good (excellent) academic performance at a university (SSU) that becomes the determining factor on the part of the employer for choosing a potential candidate for a particular vacancy.
Value-Based Management for Russian Industrial Enterprises in the Conditions of High Economic Volatility
Authors: Suslova M. A. 
Published: August 2023

Relevance. Value-Based Management is a modern effective management concept, widespread in the West companies. It’s implementation attempts at Russian industrial enterprises face top maagement the problem of the lack of sufficient research in the field of Value-based management practical application in conditions of Russian economy, which has been characterized by a high level of volatility in recent years. In addition, the specialized literature does not always correctly present the translation and interpretation of economic terms that leads to further errors in their use.Some economic categories of Value-Based Management are clarified in this study, and also the system of value factors for Russian industrial enterprise is presented. The proposed system fully reflects the current market realities of the Russian economy.The purpose is development of the Value-Based Management theoretical base and addition of a methodological approach to Value-Based Management implementation in Russian industrial enterprises.Objectives: clarification of some economic categories of Value-Based Management; compilation of the most complete list of factors affecting the value of an industrial enterprise in the Russian Federation; development of the industrial enterprise mathematical model, that is based on the proposed system of value factors.Methodology. Method of expert assessments, system analysis, and mathematical modeling were used in the study.Results. The system of value factors for Russian industrial enterprise has been developed and proposed. It is relevant in conditions of high economic volatility. Modeling of the radio-electronic industry enterprise, which is part of the state corporation, was carried out. Based on the modeling results, the factors that have the greatest impact on the enterprise activities, and the factors that are subject to maximum influence (they are risk factors for this company) for this enterprise, are identified, recommendations are given.Conclusions. The proposed value factors system can be used in strategic or operational planning of any Russian industrial enterprise. That will make possible to make adjustments to the development strategy, increasing the efficiency of managerial decisions within the framework of Value-Based Management.
Stimulation of Investment Activities to Ensure the Economic Security of the Region
Authors: Starovoit R. V. , Emelyanov S. G. , Afanasyeva L. V. , Mezhonova Zh. A. 
Published: August 2023

Relevance. Recently, the activation of investment activity has become the main method of ensuring the economic security of the region. The current economic situation has opened up new development opportunities for the regions, which without a qualitative change in the regional investment climate, activation and stimulation of investment processes for the development of the economic sectors of the region will not be realized and will not provide the necessary level of economic security. A special role in the system of coordinated and targeted measures to attract investment is assigned to the development and implementation of non-financial instruments, which is confirmed by the laws on investment activity and on public-private partnership adopted in the Kursk region.The purpose of the study is evaluate the instruments for stimulating investment activity enshrined in the legislation of the Kursk region.Objectives: on the example of the Kursk region, to consider and systematize the instruments enshrined in the legislation to stimulate investment activity and attract investment; conduct a study of the dynamics of investments in fixed assets for 2016-2020; determine the need to use new tools to attract investment in the region's economy.Methodology. Methods of system analysis, theoretical and methodological research of literary sources, monographic and comparative methods were used.Results. The most promising instruments for stimulating investment activity have been identified for use in the region in order to increase investment attractiveness in the context of ensuring the economic security of the region. Conclusions. To stimulate investment activity in the region, it is necessary to search for new tools to attract investment, among which are public-private partnerships, the implementation of elements of the Regional Investment Standard, agreements on the protection and promotion of investments. The use of these tools to stimulate investment activity will increase the investment attractiveness and, as a result, the level of economic security of the region.
The Use of a Decision Support System (MyFood) to Assess Dietary Intake Among Free-Living Older Adults in Norway: Evaluation Study
Authors: Severinsen Frida , Andersen Lene Frost , Paulsen Mari Mohn 
Published: August 2023

Background
The proportion of older adults in the world is constantly increasing, and malnutrition is a common challenge among the older adults aged ≥65 years. This poses a need for better tools to prevent, assess, and treat malnutrition among older adults. MyFood is a decision support system developed with the intention to prevent and treat malnutrition.

Objective
This study aimed to evaluate the ability of the MyFood app to estimate the intake of energy, protein, fluids, and food and beverage items among free-living older adults aged ≥65 years, primarily at an individual level and secondarily at a group level. In addition, the aim was to measure the experiences of free-living older adults using the app.

Methods
Participants were instructed to record their dietary intake in the MyFood app for 4 consecutive days. In addition, each participant completed two 24-hour recalls, which were used as a reference method to evaluate the dietary assessment function in the MyFood app. Differences in the estimations of energy, protein, fluid, and food groups were analyzed at both the individual and group levels, by comparing the recorded intake in MyFood with the 2 corresponding recalls and by comparing the mean of all 4 recording days with the mean of the 2 recalls, respectively. A short, study-specific questionnaire was used to measure the participants’ experiences with the app.

Results
This study included 35 free-living older adults residing in Norway. Approximately half of the participants had ≥80% agreement between MyFood and the 24-hour recalls for energy intake on both days. For protein and fluids, approximately 60% of the participants had ≥80% agreement on the first day of comparison. Dinner was the meal with the lowest agreement between the methods, at both the individual and group levels. MyFood tended to underestimate the intake of energy, protein, fluid, and food items at both the individual and group levels. The food groups that achieved the greatest agreement between the 2 methods were eggs, yogurt, self-composed dinner, and hot beverages. All participants found the app easy to use, and 74% (26/35) of the participants reported that the app was easy to navigate.

Conclusions
The results showed that the MyFood app tended to underestimate the participants’ dietary intake compared with the 24-hour recalls at both the individual and group levels. The app’s ability to estimate intake within food groups was greater for eggs, yogurt, and self-composed dinner than for spreads, mixed meals, vegetables, and snacks. The app was well accepted among the study participants and may be a useful tool among free-living older adults, given that the users are provided follow-up and support in how to record their dietary intake.
Depósitos de lahar en la subcuenca del Río Cutio, volcán Pico de Tancítaro, Michoacán, México
Authors: García-Tenorio Felipe , Vázquez Rosario , Mendiola Fabiola , Carlón-Allende Teodoro 
Published: August 2023

Los lahares originados en volcanes inactivos pueden causar pérdidas económicas y de vidas humanas en sus alrededores sin advertencia alguna, especialmente si no se cuenta con un registro de eventos pasados. Estos fenómenos se han estudiado en varias regiones volcánicas de México; sin embargo, en la mayoría de los casos, se carece de registros a largo plazo sobre su frecuencia y magnitud. En la presente investigación evaluamos las características de los depósitos de lahar y otros depósitos volcaniclásticos, históricos y modernos en la subcuenca del Río Cutio, ubicada al noroeste del volcán Pico de Tancítaro, cuyo drenaje natural atraviesa las localidades de Peribán de Ramos y Corona, Michoacán. En esta subcuenca se originó un lahar de tipo hiperconcentrado el día 23 de septiembre de 2018, tras 58 mm de lluvia acumulada en dos horas, que ocasionó el desbordamiento del Río Cutio. El lahar afectó la zona conurbada de Peribán y erosionó profundamente el canal del río, dejando expuestos los depósitos analizados en este trabajo. Para caracterizar dichos depósitos se llevaron a cabo análisis estratigráficos, granulométricos, datación por 14C y análisis de difracción de rayos X. Se identificaron cuatro unidades que se clasificaron, de acuerdo con su distribución granulométrica, como depósitos de flujo de escombros cohesivos. También se reconoció un horizonte interestratificado de caída de escorias y ceniza fechado por 14C en ca. 20970 años a.C. Adicionalmente, se identificaron depósitos dentro y fuera del cauce del Río Cutio, clasificados como flujos hiperconcentrados, asociados al evento de inundación súbita ocurrido en septiembre de 2018. La información obtenida aporta nuevas evidencias de registros históricos del desbordamiento recurrente del Río Cutio, con la formación de flujos hiperconcentrados y flujos de escombros, y también la ocurrencia de flujos de escombros cohesivos por el colapso gravitacional de sectores del Pico de Tancítaro, debilitados por la intensa alteración hidrotermal. En particular, los flujos de escombros cohesivos, por su capacidad de transporte, pueden tener un impacto catastrófico, ocasionando daños severos en la infraestructura civil y urbana, así como pérdida de vidas. Estas condiciones representan un peligro latente no sólo para la localidad de Peribán de Ramos, sino para otras poblaciones aledañas. Aunque el volcán Pico de Tancítaro es considerado como inactivo, los resultados del presente trabajo ponen en evidencia la necesidad de un estudio detallado para definir el peligro asociado a lahares, el cual será fundamental para la mitigación del impacto negativo en las zonas urbanas y agrícolas en áreas de posible inundación, incluyendo las localidades de Peribán de Ramos y Corona, Michoacán.