bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cosmological frame principle and cosmic acceleration
Authors: Cotsakis Spiros , Mimoso Jose P. , Miritzis John 
Published: August 2023

AbstractWe discuss implications of the cosmological frame principle which states that cosmological effects of modified gravity must be stable as solutions of each of the corresponding sets of dynamical equations holding in the two conformally-related frames. We show that there are such globally stable, ‘frame-independent’ solutions describing cosmic acceleration, suggesting that they may represent a physically relevant effect. This result highlights the importance of further investigation into the implications of the frame principle for cosmological properties that rely on the use of conformal frames.
Decomposition of quandle rings of Takasaki quandles
Authors: Kaur Dilpreet , Singh Pushpendra 
Published: August 2023

Let [Formula: see text] or [Formula: see text] and [Formula: see text] denote the Takasaki quandle of order [Formula: see text]. In this paper, we provide decomposition of quandle ring [Formula: see text] as direct sum of right simple ideals. This decomposition is equivalent to decomposition of regular representation [M. Elhamdadi and E. M. Moutuou, Finitely stable racks and rack representations, Comm. Algebra 46(11) (2018) 4787–4802] of Takasaki quandles.
DESIGNING A FRAMEWORK OF INFLUENCING VARIABLES ON OPEN INNOVATION IN STARTUP COMPANIES
Authors: SALIMI SABA , SHAHRIARI MOHSEN , SHIRANI BEHROOZ ARBAB 
Published: August 2023

Purpose — The goal of this research is to create a model of influencing factors of open innovation (OI) in startups. This research has also looked into how OI affects gaining a competitive advantage by taking into account the moderator role of environment dynamics.Design/methodology/approach — Possible factors influencing OI in startups, determined through research background studies and interviews with experts in the startup fields, then along with the factors of competitive advantage and environmental dynamics, were evaluated in a sample of 120 managers of Iranian start-up companies. Using structural equation modelling, we analysed data collected from startup managers pertaining to variables of OI, competitive advantage, and environmental dynamics. Structural equation modelling is a multivariate analysis method that enables the examination of relationships among multiple variables within a model. A two-stage partial least squares structural equation modelling method was employed in this study. In the first stage, the construct validity and reliability of the measurement models were evaluated, and in the second stage, the conceptual model and research hypotheses were put to the test.Findings — Results showed that organisational entrepreneurship, open business model, knowledge management capabilities, absorption capacity, organisational readiness, and participatory capability are important influences on OI in startups. Furthermore, the study found that applying OI techniques can help startups succeed more often in gaining a competitive edge. Additionally, the study found that environmental dynamics have a positive moderating effect on this relationship.Practical implications — Considering the vital role of startups in economic development programs, the results of this research can lead the managers of start-up companies and growth centers to use the OI approach to overcome the limitations of being new and small. Also to survive startups and increase productivity and competitive advantage, startup managers by focusing on these factors can take steps to create the necessary internal foundations in the organisation and negotiate with large companies in line with better policies.Originality/value — The study’s significant contribution is believed to be the development of a model that identifies the factors that influence OI in startups. Moreover, the study verified the influence of OI on achieving competitive advantage, as per the established model, while also considering the moderating effect of environmental dynamics on this association.
A Miniaturized Low-Loss Switchable Single- and Dual-Band Bandpass Filter
Authors: Mu Ruonan , Wu Yongle , Pan Leidan , Zhao Wei , Wang Weimin 
Published: August 2023

In this paper, a novel switchable bandpass filter is proposed. By switching p-i-n diodes on/off, the proposed filter can be switched between the single-band bandpass filter and the dual-band bandpass filter. The filter is mainly composed of eight pairs of series LC resonators, which generate passbands and transmission zeros. Considering the requirement of miniaturization and low cost, the filter is realized by interdigital capacitors and microstrip section inductors. The layout is designed by 3D simulation software HFSS, and the active part is designed by ADS software. The proposed filter has a compact structure, and its size is only

22.20

mm
×
25.66

m

m. For a demonstration, a switchable bandpass filter has been designed, fabricated, and measured. The simulated and measured results have a good agreement.
Anlotinib in Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Randomized, Double-Blind, Multicenter Phase II Trial
Authors: Chi Yihebali , Zheng Xiangqian , Zhang Yuan , Shi Feng , Cheng Ying , Guo Zhuming , Ge Minghua , Qin Jianwu , Zhang Jiewu , Li Zhendong , Zhou Xiaohong , Huang Rui , Chen Xiaohong , Liu Hui , Cheng Ruochuan , Xu Zhengang , Li Dapeng , Tang Pingzhang , Gao Ming 
Published: August 2023

Abstract

Purpose:
Alhough antiangiogenic agents are the bedrock of treatment for radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), novel antiangiogenic agents with optimized features like greater target-binding affinities and more favorable pharmacokinetics profile are needed. This phase II randomized, double-blind, placebo-controlled trial investigated the efficacy and safety of anlotinib, a multikinase inhibitor, for RAIR-DTC.

Patients and Methods:
Patients (ages between 18 and 70 years) with pathologically confirmed locally advanced or metastatic RAIR-DTC were enrolled and randomly received 12 mg anlotinib once daily or placebo on day 1 to 14 every 3 weeks. Patients on placebo were allowed to receive open-label anlotinib after disease progression. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival (OS) and safety.

Results:
Between September 2015 and August 2018, 76 and 37 patients randomly received anlotinib and placebo, respectively. Patients receiving anlotinib had a significantly longer median PFS [40.5 months, 95% confidence interval (CI), 28.3–not estimable (NE) versus placebo 8.4 months, 95% CI, 5.6–13.8; HR = 0.21, 95% CI, 0.12–0.37, P &lt; 0.001], meeting the primary endpoint. OS was still immature, with a trend of benefit with anlotinib (HR = 0.57, 95% CI, 0.29–1.12). All patients in the anlotinib group experienced adverse events (AE); 8 (10.5%) discontinued treatment due to AEs.

Conclusions:
Anlotinib demonstrated promising efficacy and favorable tolerance in the treatment of locally advanced or metastatic RAIR-DTC, supporting further research to establish its role in the treatment of this serious disease.
FDA Approval Summary: Ribociclib Indicated for Male Patients with Hormone Receptor–Positive, HER2-Negative Advanced or Metastatic Breast Cancer
Authors: Gao Jennifer J. , Osgood Christy L. , Feng Zhou , Bloomquist Erik W. , Tang Shenghui , Chang C.J. George , Ricks Tiffany K. , Hou Sherry C. , Pierce William F. , Rivera Donna R. , Pazdur Richard , Kluetz Paul G. , Amiri-Kordestani Laleh 
Published: August 2023

Abstract
On December 10, 2021, the FDA expanded the indications for ribociclib to include male patients for the treatment of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer. Ribociclib is now indicated in combination with an aromatase inhibitor (AI) as initial endocrine-based therapy in adult patients, or with fulvestrant as initial endocrine-based therapy or following disease progression on endocrine therapy (ET), in postmenopausal women or in men. The efficacy of ribociclib + AI for male patients was primarily based on previous favorable benefit-risk assessments of ribociclib from MONALEESA-2 and MONALEESA-7 trials, and supported by COMPLEEMENT-1, an open-label, single-arm, multicenter clinical trial, in which 39 male patients (n = 3,246 total patients) received ribociclib + letrozole + goserelin/leuprolide. The overall response rate (ORR) based on confirmed responses in male patients with measurable disease at baseline was 46.9% [95% confidence interval (CI), 29.1–65.3], consistent with an ORR of 43.6% (95% CI, 41.5–45.8) in the overall population. Overall, adverse reactions occurring in male patients were similar to those occurring in female patients treated with ribociclib + ET. The efficacy of ribociclib + fulvestrant for male patients was primarily based on the previous findings of a favorable benefit-risk assessment from the MONALEESA-3 trial, supported by FDA review of clinical data of a limited number of male patients treated in clinical practice receiving ribociclib + fulvestrant. The known mechanism of action, biologic rationale, and clinical information available adequately demonstrate that the efficacy and safety of ribociclib + AI/fulvestrant are similar in male and female patients. This article summarizes the FDA's decision-making and data supporting the approval of ribociclib in male patients with breast cancer, and discusses regulatory insights.
Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer
Authors: Randon Giovanni , Pietrantonio Filippo 
Published: August 2023

SummaryOverexpression of the EGFR ligands amphiregulin (AREG)/epiregulin (EREG) may be a surrogate of EGFR dependency regardless of sidedness in metastatic colorectal cancer. High AREG/EREG may be coupled with negative hyper-selection (i.e., lack of genomic drivers of primary resistance beyond RAS and BRAF) to identify patients with right-sided tumors and potential sensitivity to EGFR blockade.See related article by Williams et al., p. 4153
Initial experiences with Direct Imaging of Neuronal Activity (DIANA) in humans
Authors: Hodono Shota , Rideaux Reuben , van Kerkoerle Timo , Cloos Martijn A. 
Published: August 2023

Abstract
Functional MRI (fMRI) has been widely used to study activity patterns in the human brain. It infers neuronal activity from the associated hemodynamic response, which fundamentally limits its spatiotemporal specificity. In mice, the Direct Imaging of Neuronal Activity (DIANA) method revealed MRI signals that correlated with extracellular electric activity, showing high spatiotemporal specificity. In this work, we attempted DIANA in humans. Five experimental paradigms were tested, exploring different stimulus types (flickering noise patterns, and naturalistic images), stimulus durations (50–200 ms), and imaging resolution (2 × 2 × 5 mm3 and 1 × 1 × 5 mm3). Regions of interest (ROI) were derived from Blood Oxygen Level Dependent (BOLD) fMRI acquisitions (both EPI and FLASH based) and T1-weighted anatomical scans. In Paradigm I (n = 1), using flickering noise patterns, signals were detected that resembled possible functional activity from a small ROI. However, changes in stimulus duration did not lead to corresponding signal changes (Paradigm II; n = 1). Therefore, care should be taken not to mistake artifacts for neuronal activity. In Paradigm III (n = 3), when averaged across multiple subjects, a ~200 ms long 0.02% signal increase was observed ~100 ms after the stimulus onset (10x smaller than the expected signal). However, white matter control ROIs showed similarly large signal fluctuations. In Paradigm IV (n = 3), naturalistic image stimuli were used, but did not reveal signs of a potential functional signal. To reduce partial voluming effects and improve ROI definition, in Paradigm V (n = 3), we acquired data with higher resolution (1 × 1 × 5 mm3) using naturalistic images. However, no sign of activation was found. It is important to note that repetitive experiments with short interstimulus intervals were found to be strenuous for the subjects, which likely impacted data quality. To obtain better data, improvements in sequence and stimulus designs are needed to maximize the DIANA signal and minimize confounds. However, without a clear understanding of DIANA’s biophysical underpinnings it is difficult to do so. Therefore, it may be more effective to first investigate DIANA signals with simultaneously recorded electrophysiological signals in more controlled settings, e.g., in anesthetized mice.
Successful modulation of temporoparietal junction activity and stimulus-driven attention by fNIRS-based neurofeedback—A randomized controlled proof-of-concept study
Authors: Kohl Simon H. , Melies Pia , Uttecht Johannes , Lührs Michael , Bell Laura , Mehler David M. A. , Soekadar Surjo R. , Viswanathan Shivakumar , Konrad Kerstin 
Published: August 2023

Abstract
The right temporoparietal junction (rTPJ) is a core hub in neural networks associated with reorienting of attention and social cognition. However, it remains unknown whether participants can learn to actively modulate their rTPJ activity via neurofeedback. Here, we explored the feasibility of functional near-infrared spectroscopy (fNIRS)-based neurofeedback in modulating rTPJ activity and its effect on rTPJ functions such as reorienting of attention and visual perspective taking. In a bidirectional regulation control group design, 50 healthy participants were reinforced to either up- or downregulate rTPJ activation over 4 days of training. Both groups showed an increase in rTPJ activity right from the beginning of the training but only the upregulation group maintained this effect, while the downregulation group showed a decline from the initial rTPJ activation. This suggests a learning effect in the downregulation exclusively, making it challenging to draw definitive conclusions about the effectiveness of rTPJ upregulation training. However, we observed group-specific effects on the behavioral level. We found a significant group x time interaction effect in the performance of the reorienting of attention task and group-specific changes, with decreased reaction times (RTs) in the upregulation group and increased RTs in the downregulation group across all conditions after the neurofeedback training. Those with low baseline performance showed greater improvements. In the perspective-taking task, however, only time effects were observed that were non-group-specific. These findings demonstrate that fNIRS-based neurofeedback is a feasible method to modulate rTPJ functions with preliminary evidence of neurophysiologically specific effects, thus paving the way for future applications of non-invasive rTPJ modulation in neuropsychiatric disorders.
An atlas of trait associations with resting-state and task-evoked human brain functional organizations in the UK Biobank
Authors: Zhao Bingxin , Li Tengfei , Li Yujue , Fan Zirui , Xiong Di , Wang Xifeng , Gao Mufeng , Smith Stephen M. , Zhu Hongtu 
Published: August 2023

Abstract
Functional magnetic resonance imaging (fMRI) has been widely used to identify brain regions linked to critical functions, such as language and vision, and to detect tumors, strokes, brain injuries, and diseases. It is now known that large sample sizes are necessary for fMRI studies to detect small effect sizes and produce reproducible results. Here, we report a systematic association analysis of 647 traits with imaging features extracted from resting-state and task-evoked fMRI data of more than 40,000 UK Biobank participants. We used a parcellation-based approach to generate 64,620 functional connectivity measures to reveal fine-grained details about cerebral cortex functional organizations. The difference between functional organizations at rest and during task was examined, and we have prioritized important brain regions and networks associated with a variety of human traits and clinical outcomes. For example, depression was most strongly associated with decreased connectivity in the somatomotor network. We have made our results publicly available and developed a browser framework to facilitate the exploration of brain function-trait association results (http://fmriatlas.org/).
Toward the New Testament Canon as Fourth-Century Invention
Authors: Heaton Robert D. 
Published: August 2023

Abstract
Scholarship on the New Testament canon regularly relies on criterial and reception-historical methodologies to antedate the Christian scriptural collection well before its first advocacy as a “rule” of scripture in the 39th Festal Letter of Athanasius of Alexandria (367 CE). Pushing back against these narratives and associated tendencies, this article prefers a functional or forensic approach to the institution of a twenty-seven-book New Testament and highlights evidence demonstrating how the Athanasian episcopal canon was amplified, amended, and accepted in the Christian East and West in the decades following its promulgation. Against suggestions that the canon existed as early as the second century, this handling of data on the New Testament, a scriptural instrument set forth with authoritative and exclusionary intentions, fits the guidelines of creative discourse and historical redescription so as to credit Athanasius, in the fourth century, as the inventor of the canon regnant into the present day. Among other foci, tracing the fortunes of a subcanonical category of books shows the potential for new histories of familiar canonical evidence that may ensue, especially those that plumb the possibility of dissent to the Athanasian scriptural boundaries or augment our awareness of the place and value of such an established standard within institutional, monastic, academic, imperial, and even so-called heretical contexts in and beyond the fourth century.
Pondering Tibetan Buddhist Alterity in Peter Dickinson’s Tulku
Authors: Hale Frederick 
Published: August 2023

Abstract
Peter Dickinson’s acclaimed English novel of 1979, Tulku, is primarily an exploration of the Tibetan Buddhist custom of discerning in children reincarnations of deceased spiritual leaders who are subsequently trained to assume positions of responsibility. This fascinating work also examines other dimensions of contemplative monastic Buddhism in a remote Himalayan setting, chiefly in a lamasery. On a broader scale, Dickinson addresses such themes as the supposedly peaceful nature of the national religion in question, relations between that faith and Christianity, the possibility of finding merit in religions other than one’s own, and the role of illusion in religious belief and practice. In the present article these matters are considered against the backdrop of evolving Western images of and attitudes towards Tibet generally, its form of Buddhism in particular, and the problematic practice of discovering reincarnated tulkus.
International Cooperation during a Transboundary Crisis: A Review of Theoretical Perspectives on States’ Responses to the Coronavirus Pandemic
Authors: Minja Rasul A. 
Published: August 2023

Abstract
The coronavirus crisis has negated the widely held post-Cold War narrative that the rise of non-state actors like non-governmental organizations, social movements and firms would end up supplanting states as the main actors on the international stage. States were the first responders to emerging health-related transboundary crises before the great strides of the 19th and 20th centuries to institutionalize health cooperation. Two decades into the 21st century, the world and state-level pandemics preparedness were exposed. The pandemic wreaked havoc on all states, notwithstanding their military and economic capabilities. It surpassed power asymmetries prevailing in the community of states. Among the many purposes of International Relations (IR) theories, include an attempt to explain and predict patterns of national behaviours or understand the world “inside the heads” of actors. What, then, can we learn from IR theories about the need for states to cooperate, and why was such cooperation not forthcoming, especially during the initial phases of the outbreak? Why was the initial global response so shambolic and largely inward-looking and uncoordinated? To answer these questions, the article draws insights from various IR theoretical strands and the ensuing structural, state and individual-level explanations of various actors’ responses to the COVID-19 pandemic.
Multiannual Variability of the North Atlantic Pressure and Temperature Imposed by the Lower-Stratospheric Ozone
Authors: Kilifarska Natalya , Velichkova Tsvetelina , Mokreva Antonia 
Published: August 2023

Abstract
Analyses of the Northern Hemisphere’s sea level pressure, air surface temperature, and lower-stratospheric ozone during the period 1900–2019 reveal an existing coherence in their temporal variability. The coherence is heterogeneously distributed over the globe, and the patterns of ozone impact on the pressure and temperature are different. More specifically, the strongest ozone influence on the sea level pressure is found in the main “centers of action”—that is, the Aleutian low and the region of NAO formation. The ozone influence is localized mainly in the latitudinal belt 40°–75°N, where the ozone mixing ratio at 70 hPa is reduced during most of the twentieth century (relative to the first decade of the twenty-first century). This peculiarity of ozone spatial distribution we attribute to the energetic particles trapped in Earth’s radiation belts, activating ion-molecular reactions of ozone production in the region of Regener–Pfotzer ionization maximum. Consequently, the spatial–temporal variations of the lower-atmospheric ionization could be a good explanation for irregularly distributed ozone and its regionally specified impact on the climatic variables.

Significance Statement
We tried to understand the regional character of the Northern Hemisphere’s winter weather conditions. The latter is usually attributed to the North Atlantic Oscillation (NAO), but we actually do not know the factors impacting the NAO variability itself. We found that, at multiannual time scales, the surface pressure is only weakly related to the temperature variations, whereas its correlation with the ozone at 70 hPa is unexpectedly strong—especially in the active regions of the weather phenomena formation. We attribute the ozone variability itself to the variable intensity of energetic particles precipitating in the lower atmosphere—where they activate ion-molecular reactions producing ozone. This finding opens new horizons for understanding the regionality of atmospheric variation at different time scales.