bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary bamboo leaf flavonoids improve quality and microstructure of broiler meat by changing untargeted metabolome
Authors: Cao Guangtian , Wang Huixian , Yu Yang , Tao Fei , Yang Huijuan , Yang Shenglan , Qian Ye , Li Hui , Yang Caimei 
Published: April 2023

Abstract
Background
Dietary bamboo leaf flavonoids (BLFs) are rarely used in poultry production, and it is unknown whether they influence meat texture profile, perceived color, or microstructure.

Results
A total of 720 one-day-old Arbor Acres broilers were supplemented with a basal diet with 20 mg bacitracin/kg, 50 mg BLFs/kg, or 250 mg BLFs/kg or without additions. Data showed that the dietary BLFs significantly (P < 0.05) changed growth performance and the texture profile. In particular, BLFs increased birds’ average daily gain and average daily feed intake, decreased the feed:gain ratio and mortality rate, improved elasticity of breast meat, enhanced the gumminess of breast and leg meat, and decreased the hardness of breast meat. Moreover, a significant (P < 0.05) increase in redness (a*) and chroma (c*) of breast meat and c* and water-holding capacity of leg meat was found in BLF-supplemented broilers compared with control broilers. In addition, BLFs supplementation significantly decreased (P < 0.05) the β-sheet ratio and serum malondialdehyde and increased the β-turn ratio of protein secondary structure, superoxide dismutase, and glutathione peroxidase of breast meat and total antioxidant capacity and catalase of serum. Based on the analysis of untargeted metabolome, BLFs treatment considerably altered 14 metabolites of the breast meat, including flavonoids, amino acids, and organic acids, as well as phenolic and aromatic compounds.

Conclusions
Dietary BLFs supplementation could play a beneficial role in improving meat quality and sensory color in the poultry industry by changing protein secondary structures and modulating metabolites.
The efficacy and safety of high-dose nonsedating antihistamines in chronic spontaneous urticaria: a systematic review and meta-analysis of randomized clinical trials
Authors: Xiao Xianjun , Xue Peiwen , Shi Yunzhou , Yao Junpeng , Cao Wei , Zhang Leixiao , Zou Zihao , Zhou Siyuan , Wang Chuan , Chen Mingling , Jin Rongjiang , Li Ying , Zheng Qianhua 
Published: April 2023

Abstract
Background
Standard doses of second-generation H1-antihistamines (sgAHs) as first-line treatment are not always effective in treating chronic spontaneous urticaria (CSU), and hence an increase in the dose of sgAHs is recommended. However, literature evaluating the efficacy and safety of this treatment remains inconclusive, highlighting the need for a systematic review and meta-analysis. The aim of this systematic review and meta-analysis was to evaluate the efficacy and safety of high-dose sgAHs compared with standard-dose sgAHs in treating CSU.

Methods
A systematic literature search of double-blind, randomized controlled trials (RCT) utilizing multiple doses of sgAHs was performed by searching the electronic databases Medline, Embase, PsycInfo, Cochrane databases, and Web of Science. Bibliographies were also manually searched. The Cochrane Risk of Bias Tool for assessing risk of bias was used to assess the quality of randomized controlled trials (RCTs). Two reviewers screened studies, extracted data, and evaluated the risk of bias independently. The response rate, the number of adverse events, somnolence, and withdrawal due to adverse events were extracted from each article. The data were combined and analyzed to quantify the safety and efficacy of the treatment. RevMan (V5.3) software was used for data synthesis.

Results
A total of 13 studies were identified, seven of which met the eligibility criteria for the meta-analysis. Our pooled meta-analyses showed that high-dose sgAHs was associated with a significantly higher response rate than standard-dose (RR 1.13, 95% CI 1.02 to 1.26; P = 0.02). Conversely, high doses of sgAHs were associated with significantly higher somnolence rates than standard dose (RD 0.05, 95% CI 0.01 to 0.09; P = 0.02). There was no significant difference in adverse events or withdrawal due to adverse events between standard- and high-dose treatments.

Conclusions
Our analyses showed that a high dose of sgAHs (up to two times the standard dose) might be more effective than a standard dose in CSU treatment. High-dose and standard-dose sgAHs showed similar adverse events, except for somnolence, where incidence was found to be dose-dependent in some studies. However, given the limited number of studies, our meta-analysis results should be interpreted with caution.
Reconstruction of historical hygrometric time series for the application of the European standard EN 15757:2010 and its comparison with current time series
Authors: Díaz-Arellano Ignacio , Zarzo Manuel , Aransay Cristina , González de Aspuru Hidalgo Sara , Laborda Jaime , Perles Angel 
Published: April 2023

Abstract
The quality and quantity of thermo-hygrometric data are essential to carry out an appropriate assessment of the microclimate from a preventive conservation standpoint in those spaces where the artefacts to be preserved are located. These analyses are fundamental for long-term preventive conservation plan to assess chemical, biological or fracture risks. However, many small and medium-sized museums as well as heritage buildings have only a limited amount of historical data, with various problems that hinder the evaluation of microclimatic conditions. Two of the most common problems are short monitoring time periods, usually less than one year, and low sampling rates of measurements. In many of these situations, guidelines such as the European standard EN 15757:2010 cannot be applied because they require a monitoring period of at least 13 months and a minimum sampling frequency of one measurement per hour. In addition to these issues, there are other drawbacks such as missing values or lack of regularity in data collection. This paper proposes a procedure for the reconstruction of historical thermo-hygrometric data using multivariate statistical methods. The methodology allows the arrangement of long historical series of sufficient quality, enabling museums to restore their datasets for further analysis regarding the application of guidelines for preventive conservation. The methodology has been validated on the basis of real data. The application of the European standard EN 15757:2010 is presented as a practical example of the procedure using historical data collected at a partner museum of the H2020 CollectionCare project, together with data currently being collected for some months by a set of wireless sensor nodes.
Weathering assessment approach for building sandstone using hyperspectral imaging technique
Authors: Yang Haiqing , Ni Jianghua , Chen Chiwei , Chen Ying 
Published: April 2023

Abstract
Weathering is one of the most common causes of building sandstone damage. The evolution of building sandstone in various weathering behaviors is critical for research. An intelligent assessment approach for classifying weathering degree of building sandstone in a humid environment is presented in this study. This synthesis method relates to three parts: microscopic observation of weathering characteristics, hyperspectral acquisition of weathered samples, and machine learning technology for a classification model. At first, weathering process is divided into initial weathered stage, accelerated weathered stage, and stable weathered stage according to the causes and mechanisms of weathering. Secondly, a novel classification method of weathering degree is proposed based on the weathering stage. Then, the mapping relationship between microscopic characteristics and hyperspectral image of shedding samples can be established in the visible and near-infrared spectral ranges (400–1000 nm) according to the change law of spectral absorption feature. Next, the spectral data of building sandstone with different weathering degrees are classified using Random Forest model. Furthermore, the hyperparameters of Random Forest model are optimized by Gray Wolf Optimizer algorithm for better performance. The trained model is finally applied to evaluate the weathering degree of large-scale sandstone walls quantitatively. The whole weathering assessment process is worth recommending for diagnosing and monitoring the building sandstone.
Short-term effects of a classroom-based STEAM program using robotic kits on children in South Korea
Authors: Sung Jihyun , Lee Ji Young , Chun Hui Young 
Published: April 2023

Abstract
Background
Despite the recent emphasis on technology and engineering in early childhood education, the importance of teaching relevant concepts in early education has been underappreciated in South Korea. This study examined the feasibility and efficacy of a science, technology, engineering, art, and mathematics (STEAM) program integrated into the national curriculum in a Korean early childhood education setting. Children aged 5–6 years (231 girls and 219 boys; treatment group: 334 children; control group: 116 children) were tested on computational thinking, vocabulary, numeracy, self-regulation, and social behavior before and after receiving STEAM curriculum that included robotics activities or an equivalent curriculum.

Results
Findings revealed that among the outcome measures, young children in the treatment group exhibited significant increases in computational thinking and expressive vocabulary. Moreover, gender demonstrated a significant interaction effect with the increase in computational thinking as measured by an assessment developed for a specific robotic material as well as in self-regulation and social behavior.

Conclusions
This study provides empirical and comprehensive evidence regarding the effectiveness of an integrated STEAM program with developmentally appropriate robotic kits for young children.
“Trustworthiness,” confidence in estimated effects, and confidently translating research into clinical practice
Authors: Riley Sean P. , Swanson Brian T. , Cook Chad E. 
Published: April 2023

AbstractTrustworthy, preprocessed sources of evidence, such as systematic reviews and clinical practice guidelines, are crucial for practicing clinicians. Confidence in estimated effects is related to how different the outcome data were between the two groups. Factors including the effect size, variability of the effect, research integrity, research methods, and selected outcome measures impact confidence in the estimated effect. The current evidence suggests that post-randomization biases cannot be ruled out with a high degree of certainty in published research, limiting the utility of preprocessed sources for clinicians. Research should be prospectively registered to improve this situation, and fidelity with prospective intent should be verified to minimize biases and strengthen confidence in estimated effects. Otherwise, discussions related to preprocessed literature, including P-values, point estimates of effect, confidence intervals, post-randomization biases, external and internal validity measures, and the confidence in estimated effects required to translate research into practice confidently, are all moot points.
Effective participation of wind turbines in frequency control of a two-area power system using coot optimization
Authors: El-Bahay Mahmoud Hussain , Lotfy Mohammed Elsayed , El-Hameed Mohamed A. 
Published: April 2023

AbstractIn this paper, load frequency control is performed for a two-area power system incorporating a high penetration of renewable energy sources. A droop controller for a type 3 wind turbine is used to extract the stored kinetic energy from the rotating masses during sudden load disturbances. An auxiliary storage controller is applied to achieve effective frequency response. The coot optimization algorithm (COA) is applied to allocate the optimum parameters of the fractional-order proportional integral derivative (FOPID), droop and auxiliary storage controllers. The fitness function is represented by the summation of integral square deviations in tie line power, and Areas 1 and 2 frequency errors. The robustness of the COA is proven by comparing the results with benchmarked optimizers including: atomic orbital search, honey badger algorithm, water cycle algorithm and particle swarm optimization. Performance assessment is confirmed in the following four scenarios: (i) optimization while including PID controllers; (ii) optimization while including FOPID controllers; (iii) validation of COA results under various load disturbances; and (iv) validation of the proposed controllers under varying weather conditions.
A review on the immunomodulatory properties of functional nutraceuticals as dietary interventions for children to combat COVID-19 related infections
Authors: Soni Swati , Paari Kuppusamy Alagesan 
Published: April 2023

AbstractCOVID-19 is a significant threat to humanity in the present day due to the rapid increase in the number of infections worldwide. While most children may be spared of the direct mortality effects of the disease, those with weak immune systems are prone to adverse effects. Child mortality increases due to the stress caused to the health care system that disrupts essential health care needs such as immunisation and antenatal care. The use of functional foods (FF) aids in disease-prevention as they are known to have protective effects against COVID-19 by boosting children’s cellular and humoral immunity. Plant components such as glycyrrhizin, epigallocatechin gallate, allicin, and fucoidan exhibit antiviral properties against various viruses, including SARS-CoV 2. Microbial foods that are made of probiotics, can enhance immunity against various respiratory viruses. Food enriched with additives such as lactoferrin, piperine, and zinc can boost immunity against COVID-19. With proper definitive drug therapy not available for treating COVID-19 and most of the disease management tools rely on symptoms and non-specific supportive care, developing a functional paediatric formulation will prevent further deterioration in infant health. It is wise to investigate the toxicological aspects of Functional Foods components especially when formulating for children. The safe limits of ingredients should be strictly followed during FFs formulation. Stronger regulations with advanced analytical techniques can help to formulate functional foods into the mainstream in child nutraceuticals. The purpose of this review is to compile collective information on the functional nutraceuticals specifically for infants and children up to the age of 10 years that could confer immunity against COVID-19 and other related viruses.
Graphical Abstract
Denoising distributed acoustic sensing data using unsupervised deep learning
Authors: Yang Liuqing , Fomel Sergey , Wang Shoudong , Chen Xiaohong , Chen Yangkang 
Published: April 2023

Distributed acoustic sensing (DAS) technology has been widely used in seismic exploration to acquire high-quality data due to its noteworthy advantages, such as high coverage, high resolution, low cost, and strong environmental friendliness. However, the seismic signals acquired in DAS are often masked by various types of noise (e.g., high-frequency random, high-amplitude erratic, horizontal, and coupled noise), which seriously decreases the signal-to-noise ratio. We develop a fully connected neural network with dense and residual connections to attenuate various complex noises in real DAS data. The network is designed to learn the features of useful reflection signals and remove various noises in an unsupervised way, therefore enjoying the convenience of label-free processing. Our network uses several encoders and decoders to compress and reconstruct the abstract waveform features, respectively. Each encoder/decoder consists of one dense block with stacked fully connected blocks (FCBs). To transfer the shallow-level features to the deep level for reuse, we add the skip connections with one FCB between the corresponding encoders and decoders. Our method provides encouraging results when applied to synthetic and real DAS data sets. Compared with several traditional and advanced deep-learning methods, our method can more effectively attenuate strong noise and better extract hidden signals.
Effect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer
Authors: Badwe Rajendra A. , Parmar Vani , Nair Nita , Joshi Shalaka , Hawaldar Rohini , Pawar Suraj , Kadayaprath Geeta , Borthakur Bibhuti B. , Rao Thammineedi Subramanyeshwar , Pandya Shashank , Balasubramanian Satheesan , Chitale Priyadarshan V. , Neve Rakesh , Harris Caleb , Srivastava Anurag , Siddique Shabina , Vanmali Vaibhav J. , Dewade Ashwini , Gaikwad Varsha , Gupta Sudeep 
Published: April 2023

PURPOSE Preventing metastases by using perioperative interventions has not been adequately explored. Local anesthesia blocks voltage-gated sodium channels and thereby prevents activation of prometastatic pathways. We conducted an open-label, multicenter randomized trial to test the impact of presurgical, peritumoral infiltration of local anesthesia on disease-free survival (DFS). METHODS Women with early breast cancer planned for upfront surgery without prior neoadjuvant treatment were randomly assigned to receive peritumoral injection of 0.5% lidocaine, 7-10 minutes before surgery (local anesthetics [LA] arm) or surgery without lidocaine (no LA arm). Random assignment was stratified by menopausal status, tumor size, and center. Participants received standard postoperative adjuvant treatment. Primary and secondary end points were DFS and overall survival (OS), respectively. RESULTS Excluding eligibility violations, 1,583 of 1,600 randomly assigned patients were included in this analysis (LA, 796; no LA, 804). At a median follow-up of 68 months, there were 255 DFS events (LA, 109; no LA, 146) and 189 deaths (LA, 79; no LA, 110). In LA and no LA arms, 5-year DFS rates were 86.6% and 82.6% (hazard ratio [HR], 0.74; 95% CI, 0.58 to 0.95; P = .017) and 5-year OS rates were 90.1% and 86.4%, respectively (HR, 0.71; 95% CI, 0.53 to 0.94; P = .019). The impact of LA was similar in subgroups defined by menopausal status, tumor size, nodal metastases, and hormone receptor and human epidermal growth factor receptor 2 status. Using competing risk analyses, in LA and no LA arms, 5-year cumulative incidence rates of locoregional recurrence were 3.4% and 4.5% (HR, 0.68; 95% CI, 0.41 to 1.11), and distant recurrence rates were 8.5% and 11.6%, respectively (HR, 0.73; 95% CI, 0.53 to 0.99). There were no adverse events because of lidocaine injection. CONCLUSION Peritumoral injection of lidocaine before breast cancer surgery significantly increases DFS and OS. Altering events at the time of surgery can prevent metastases in early breast cancer (CTRI/2014/11/005228). [Media: see text]
Contextuality and correlation loopholes are equivalent
Authors: López Álvaro G. 
Published: April 2023

Abstract
We show that contextual hidden variables including the effect of the measuring devices can be backward-propagated by means of the Green's function to initial Cauchy hidden data. If this data is uncorrelated in spacelike-disjoint sets, the CHSH-Bell inequality can be derived. However, the correlation loophole remains unclosed.
New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study
Authors: Puglisi Soraya , Calabrese Anna , Ferraù Francesco , Violi Maria Antonia , Laganà Marta , Grisanti Salvatore , Ceccato Filippo , Scaroni Carla , Di Dalmazi Guido , Stigliano Antonio , Altieri Barbara , Canu Letizia , Loli Paola , Pivonello Rosario , Arvat Emanuela , Morelli Valentina , Perotti Paola , Basile Vittoria , Berchialla Paola , Urru Sara , Fiori Cristian , Porpiglia Francesco , Berruti Alfredo , Pia Anna , Reimondo Giuseppe , Cannavò Salvatore , Terzolo Massimo 
Published: April 2023

Abstract

Context
Because of the rarity of adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in the characterization of patients and their treatment.

Objective
To describe in a nationwide cohort the presentation of patients with ACC, treatment strategies, and potential prognostic factors.

Methods
Retrospective analysis of 512 patients with ACC, diagnosed in 12 referral centers in Italy from January 1990 to June 2018.

Results
ACC diagnosed as incidentalomas accounted for overall 38.1% of cases, with a frequency that increases with age and with less aggressive pathological features than symptomatic tumors. Women (60.2%) were younger than men and had smaller tumors, which more frequently secreted hormones. Surgery was mainly done with an open approach (72%), and after surgical resection, 62.7% of patients started adjuvant mitotane therapy. Recurrence after tumor resection occurred in 56.2% of patients. In patients with localized disease, cortisol secretion, ENSAT stage III, Ki67%, and Weiss score were associated with an increased risk of recurrence, whereas margin-free resection, open surgery, and adjuvant mitotane treatment were associated with reduced risk. Death occurred in 38.1% of patients and recurrence-free survival (RFS) predicted overall survival (OS). In localized disease, age, cortisol secretion, Ki67%, ENSAT stage III, and recurrence were associated with increased risk of mortality. ACCs presenting as adrenal incidentalomas showed prolonged RFS and OS.

Conclusion
Our study shows that ACC is a sex-related disease and demonstrates that an incidental presentation is associated with a better outcome. Given the correlation between RFS and OS, RFS may be used as a surrogate endpoint in clinical studies.
Moving Closer for the Grandchild? Fertility and the Geographical Proximity of a Mother and Her Adult Daughter in a Dynamic Perspective
Authors: Rutigliano Roberta , Schnor Christine , Zilincikova Zuzana 
Published: April 2023

AbstractRecent research has analyzed how the geographical distance between mothers and adult daughters influenced the daughters' fertility transitions. The inverse relationship has received less attention: that is, whether a daughter's fertility—her pregnancies and the ages and number of her children—is affected by her geographical proximity to her mother. The current study helps to close this gap by considering moves by either adult daughters or mothers that lead them to live nearby again. We use Belgian register data on a cohort of 16,742 firstborn girls aged 15 at the beginning of 1991 and their mothers who lived apart at least once during the observed period (1991–2015). Estimating event-history models for recurrent events, we analyzed whether an adult daughter's pregnancies and the ages and number of her children affected the likelihood that she was again living close to her mother and, if so, whether the daughter's or the mother's move enabled this close living arrangement. The results show that daughters were more likely to move closer to their mothers during their first pregnancy and that mothers were more likely to move closer to their daughters when the daughters' children were older than 2.5 years. This study contributes to the growing literature investigating how family ties shape (im)mobility.