bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of industry 4.0‐enabled data‐driven shared platform as an enabler of product‐service system in the context of circular economy: A systematic literature review and future research directions
Authors: Atif Sehrish 
Published: March 2023

AbstractThe integration of innovative technologies creates a circular economy (CE) system that enhances the value and legitimacy of their trade. Recently, many global industries have shifted their focus towards product‐service system (PSS) to perpetuate in today's competitive market without negatively influencing the environmental detrition and retaining the extended producer responsibility (EPR). Thus, this study will advance an understanding of how I4.0 technologies derivate renewables from waste to create sustainable energy sources rather than consuming virgin resources (normally considered a linear model) from a data management and product lifecycle perspective. This research used the Systematic Literature Review (SLR) methodology to analyse and categorise a literature survey of 126 research articles published over the years (2013–2022). The analysis indicates that the early research is mostly focused on defining the key variables (CE, I4.0 and PSS) and developing various frameworks to promote eco‐efficient services and sustainable development using I4.0 technologies and is engineering focused. It is established that two propositions leverage CE; the first one is value co‐creation, which enhances perceived value. In contrast, the other one is related to the application of data‐driven platforms using I4.0 technologies for sculpting the strategy and other decision support. More studies need to be analysing CE, I4.0 and PSS. To support researchers, managers and policymakers, this study has analysed the applicability of theoretical propositions regarding the application of I4.0 technologies with CE and PSS and presented a theoretical framework for the I4.0‐enabled share platform that may be tested using empirical data.
Economic evaluations of mental health interventions in criminal justice
Authors: Knapp Martin , Wong Gloria 
Published: March 2023

AbstractBackgroundMental health interventions targeting crime perpetrators are available. An overview of the current scenario of their economic benefits will help policy decisions.AimTo provide an update on economic evidence for mental health interventions in criminal justice, and to identify challenges and responses in using economic evidence to inform policy.MethodNarrative review with an analysis frame that organises evidence around four points on the criminal justice system pathway: (a) point of contact; (b) post‐arrest; (c) incarceration/punishment and (d) post‐incarceration.ResultsThere is a paucity of high‐quality economic evidence, especially from cost‐benefit analyses. However, there is some evidence of cost‐effectiveness in support of interventions at the point of incarceration, such as cognitive behavioural therapy, multisystemic therapy for juvenile delinquents, therapeutic communities, electronic monitoring and telepsychiatry in forensic psychiatry settings. There is also evidence that post‐incarceration interventions such as assertive community treatment can be cost‐effective.ConclusionThere remain large evidence gaps. There are also challenges in turning economic evidence on mental health interventions in criminal justice into policy changes and improved practice, such as hidden costs, silo budgeting and delayed pay‐off. Research incorporating multi‐sectoral costs and benefits recommended by health economics and health technology assessment groups should be prioritised to support difficult resource allocation decisions faced by policy makers.
Balancing sub‐reaction activity to boost electrocatalytic urea synthesis using a metal‐free electrocatalyst
Authors: Chen Chen , Li Shuang , Zhu Xiaorong , Bo Shuowen , Cheng Kai , He Nihan , Qiu Mengyi , Xie Chao , Song Dezhong , Liu Youzhen , Chen Wei , Li Yafei , Liu Qinghua , Li Conggang , Wang Shuangyin 
Published: March 2023

AbstractElectrocatalytic urea synthesis via coupling of nitrate with CO2 is considered as a promising alternative to the industrial urea synthetic process. However, the requirement of sub‐reaction (NO3RR and CO2RR) activities for efficient urea synthesis is not clear and the related reaction mechanisms remain obscure. Here, the construction, breaking, and rebuilding of the sub‐reaction activity balance would be accompanied by the corresponding regulation in urea synthesis, and the balance of sub‐reaction activities was proven to play a vital role in efficient urea synthesis. With rational design, a urea yield rate of 610.6 mg h−1 gcat.−1 was realized on the N‐doped carbon electrocatalyst, superior to that of noble‐metal electrocatalysts. Based on the operando SR‐FTIR measurements, we proposed that urea synthesis arises from the coupling of *NO and *CO to generate the key intermediate of *OCNO. This work provides new insights and guidelines into urea synthesis from the aspect of activity balance.
Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity†
Authors: Bolshakova Valeriya S. , Sinegubova Ekaterina O. , Esaulkova Yana L. , Peregudov Alexander S. , Khakina Ekaterina A. , Slesarenko Nikita A. , Shestakov Alexander F. , Zarubaev Vladimir V. , Troshin Pavel A. , Kraevaya Olga A. 
Published: March 2023

Comprehensive SummaryHerein, we present a facile synthesis of amide‐type water‐soluble fullerene derivatives decorated with five residues of amino acids. As compared to the previously developed approaches, the proposed method enables usage of a broad range of amino acids, including those unstable under Friedel‐Crafts reaction conditions. Furthermore, it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl, H, alkyl. The synthesized amide‐type water‐soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine‐resistant influenza А/Puerto Rico/8/34 (Н1N1) virus in vitro.
Chronic health conditions among long‐term survivors of adolescent and young adult cancer: A comparison of outcomes in Israel and the United States
Authors: Hayek Samah , Libresco Gilad , Barda Noam , Chao Chun , Xu Lanfang , Cannavale Kimberly L. , Izraeli Shai , Armenian Saro H. 
Published: March 2023

AbstractBackgroundThere is a paucity of information on health outcomes of adolescent and young adult (AYA) cancer survivors living outside North America and Europe. This study compared outcomes in AYA cancer survivors in Israel with individuals without cancer and similar demographics and access to health care, and to AYA cancer survivors living in the United States.MethodsThis study included 12,674 2‐year survivors of AYA (aged 15–39 years) cancer diagnosed between 2000 and 2018 at Clalit Health Services (CHS) in Israel. CHS participants without cancer (N = 50,696) were matched 4:1 to survivors on age, sex, ethnicity, and membership duration. Poisson regression was used to determine incidence rate ratios (IRRs) for chronic conditions. The US Kaiser Permanente Southern California AYA cohort (N = 6778) was used to estimate weighted (age, sex) standardized incidence ratios (SIRs) for CHS survivors.ResultsCHS AYA cancer survivors were more likely to have any chronic condition (IRR, 1.6 95% CI, 1.5–1.7), compared with participants without cancer. Survivors had an increased risk across nearly all conditions examined, with especially elevated risks for osteoporosis (IRR, 4.7; 95% CI, 4.1–5.5) and cardiomyopathy (IRR, 4.2 95% CI, 3.4–5.3). Compared with the Kaiser Permanente Southern California cohort, CHS survivors had an overall lower (SIR, 0.68; 95% CI, 0.65–0.72) incidence of developing any health condition, with noticeably lower incidence of hyperlipidemia (SIR, 0.7; 95% CI, 0.64–0.75).ConclusionAYA cancer survivors in Israel are at increased risk for developing chronic conditions compared with individuals without cancer, but the overall incidence was lower than in US survivors. These findings may allow for refinement of surveillance recommendations for AYA survivors, taking into consideration regional differences in sociodemographic characteristics and cancer care.Plain language summary

The burden of chronic conditions was consistently greater in Israeli adolescent and young adult cancer survivors compared with individuals without cancer, with clear differences in risk of specific conditions by cancer diagnosis.

However, the overall incidence of chronic conditions in Israeli survivors was generally lower than in US survivors.
Application of Ion Chromatography for the Reliable Quantification of Ammonium in Electrochemical Ammonia Synthesis Experiments: A Practical Guide
Authors: Bragulla Sebastian C. H. , Lorenz Julian , Harms Corinna , Wark Michael , Friedrich K. Andreas 
Published: March 2023

AbstractAssessing novel electrocatalysts for the electrochemical ammonia synthesis (EAS) requires reliable quantitative trace analysis of electrochemically produced ammonia to infer activity and selectivity. This study concerns the development of an ion chromatography (IC) method for quantitative trace analysis of ammonium in 0.1 M sulfuric acid electrolyte, which is applied to EAS gas‐diffusion electrode (GDE) experiments with commercial chromium nitride as electrocatalyst. The developed IC method is highly sensitive, versatile, and reliable, achieving a limit of quantification (LOQ) of 6 μg l−1 (6 ppbmol) ammonium. The impacts of the sample matrix, dilution, and neutralization, as well as contamination, on the quantitative analysis by IC are analyzed. Experimental constraints result in an effective LOQ including dilution of 60 μg l−1 for the determination of ammonium in 0.1 M sulfuric acid electrolyte, owing to necessary sample dilution. The practical guide presented herein is intended to be very relevant for the field of EAS as a guideline and applicable to a broad range of catalyst systems and ion chromatography devices.
The medulla controls effector primed γδT‐cell development in the adult mouse thymus
Authors: James Kieran D. , White Andrea J. , Jenkinson William E. , Anderson Graham 
Published: March 2023

AbstractγδT cells are produced in the thymus throughout life and provide immunity at epithelial‐rich sites. Unlike conventional αβT cells, γδT‐cell development involves intrathymic acquisition of effector function, with priming for either IL17 or IFN‐γ production occurring during embryonic or adult life, respectively. How the thymus controls effector‐primed γδT‐cell generation in adulthood is poorly understood. Here, we distinguished de novo γδT cells from those undergoing thymus recirculation and/or retention using Rag2GFP mice alongside markers of maturation/effector priming including CD24, CD25, CD73, and IFN‐γ, the latter by crossing with IFN‐γYFP GREAT mice. We categorize newly developing γδT‐cells into an ordered sequence where CD25+CD73−IFN‐γYFP− precursors are followed sequentially by CD25−CD73+IFN‐γYFP− intermediates and CD25−CD73+IFN‐γYFP+ effectors. To determine intrathymic requirements controlling this sequence, we examined γδT‐cell development in Relb−/− thymus grafts that lack medullary microenvironments. Interestingly, medulla deficiency did not alter CD25+ γδT‐cell precursor generation, but significantly impaired development of effector primed stages. This impact on γδT‐cell priming was mirrored in plt/plt mice lacking the medullary chemoattractants CCL19 and CCL21, and also Ccl21a−/− but not Ccl19−/− mice. Collectively, we identify the medulla as an important site for effector priming during adult γδT‐cell development and demonstrate a specific role for the medullary epithelial product CCL21 in this process.
Hybrid dingo and whale optimization algorithm‐based optimal load balancing for cloud computing environment
Authors: Ramya K. , Ayothi Senthilselvi 
Published: March 2023

AbstractCloud computing is the most rapidly growing technology that facilitates virtualized computer resources to the users through its service providers. Load balancing and task scheduling is the important concern in the cloud computing scenario from the service provider point of view. The process of load balancing is responsible for allocating the dynamic workload among the cloud systems, such that equal sharing of the resources without the virtual machines (VMs) being overloaded or underloaded. This load balancing process not only needs to allocate the tasks to suitable VMs but also need to maintain trade‐off among VMs. Thus, a potential dynamic and optimized load balancing strategy is essential for improving resource utilization, services, reliability, and throughput by maintaining equilibrium between VMs with minimized makespan. In this article, hybrid dingo and whale optimization algorithm‐based load balancing mechanism (HDWOA‐LBM) is proposed for effective load balancing those aids in maximized throughput, reliability, and resource utilization in the clouds. This HDWOA‐LBM is proposed by mimicking the hunting characteristics of dingo (equivalent to tasks) and VMs as their prey to be hunted. It inherited the process of exploration and exploitation through the chasing and approaching, encircling, and harassing inherent with dingo optimization algorithm (DOA) to determine the optimal allocation of incoming tasks to the suitable VM. In specific, it utilized the merits of whale optimization for improving the exploitation phase of DOA to balance the trade‐off between local and global search. The simulation experiments of the proposed HDWOA‐LBM conducted using CloudSim confirmed better throughput of 21.28%, maximized reliability of 25.42%, minimized makespan of 22.98%, and improved resource allocation of 20.86%, on par with the competitive intelligent load balancing schemes used for investigation.
Psychometric approaches to defining cognitive phenotypes in the Old Order Amish
Authors: Zaman Andrew , Caywood Laura , Prough Michael , Clouse Jason , Harrington Sharlene , Adams Larry , Fuzzell Denise , Fuzzell Sarada , Laux Renee , Hochstetler Sherri D. , Ogrocki Paula , Lerner Alan , Vance Jeffery M. , Haines Jonathan L. , Scott William K. , Pericak‐Vance Margaret A. , Cuccaro Michael L. 
Published: March 2023

AbstractObjectiveMemory and cognitive problems are central to the diagnosis of Alzheimer's disease (AD). Psychometric approaches to defining phenotypes can aid in identify genetic variants associated with AD. However, these approaches have mostly been limited to affected individuals. Defining phenotypes of both affected and unaffected individuals may help identify genetic variants associated with both AD and healthy aging. This study compares psychometric methods for developing cognitive phenotypes that are more granular than clinical classifications.Methods682 older Old Order Amish individuals were included in the analysis. Adjusted Z‐scores of cognitive tests were used to create four models including (1) global threshold scores or (2) memory threshold scores, and (3) global clusters and (4) memory clusters. An ordinal regression examined the coherence of the models with clinical classifications (cognitively impaired [CI], mildly impaired [MI], cognitively unimpaired), APOE‐e4, sex, and age. An ANOVA examined the best model phenotypes for differences in clinical classification, APOE‐e4, domain Z‐scores (memory, language, executive function, and processing speed), sex, and age.ResultsThe memory cluster identified four phenotypes and had the best fit (χ2 = 491.66). Individuals in the worse performing phenotypes were more likely to be classified as CI or MI and to have APOE‐e4. Additionally, all four phenotypes performed significantly differently from one another on the domains of memory, language, and executive functioning.ConclusionsMemory cluster stratification identified the cognitive phenotypes that best aligned with clinical classifications, APOE‐e4, and cognitive performance We predict these phenotypes will prove useful in searching for protective genetic variants.
Cognitive reserve and dementia risk management in people with an intellectual disability
Authors: Allen Andrew P. , McGlinchey Eimear , Fallon Marianne , McCallion Philip , McCarron Mary 
Published: March 2023

Key Points

Dementia risk is elevated in people with intellectual disability, particularly for those with Down syndrome
Differences in lifestyle factors have been cited as factors that exacerbate dementia risk in people with intellectual disability
Lifestyle factors can be targeted to enhance cognitive reserve and reduce dementia risk for people with intellectual disability
Preventing pressure injury in open‐heart surgical patients: A systematic review
Authors: Taghiloo Hamed , Ebadi Abbas , Saeid Yaser , Jalali Farahni Alireza , Davoudian Atefeh 
Published: March 2023

AbstractBackgroundCardiac surgical patients are highly prone to developing surgery‐related Pressure injuries (PIs). Prevention of PIs is an important patient safety priority in healthcare settings and patients care. So the aim of this study is to detect the effectiveness of prevention strategies to decrease PIs prevalence and incidence in patients undergoing open heart surgery.MethodWe identified studies through Web of Science, Scopus, PubMed, Cochrane, and ProQuest databases from inception through September 2022 with restrictions on the English language. Cochrane RoB 2, JBI, and NIH checklist were carried out as critical appraisal Tools to investigate the studies risk of bias. Finally, 10 studies with a total sample No. 1348, which fulfilled eligibility criteria were included in final systematic review.ResultMost common interventions investigated in included studies were addressing impairments skin care which included the use of multilayer silicone foam, Care bundle and multiple intervention programs, alternative head inflatable pads, pressure‐reducing foam mattresses, and electric bed frames as the effective PIs Prevention (PIP) strategies. While repositioning is one of the important causes mentioned in most PIP protocols, there was not adequate evidence to recommend any special turning regimens for PIP.ConclusionGiven current evidence, multilayer silicone foam, Care bundle and multiple intervention programs, alternative inflatable head pads, pressure‐reducing foam mattresses, and electric bed frames are effective strategies to prevent pressure ulcers. Further investigations are needed to specify the cost‐effectiveness of mentioned strategies and RCTs to determine other PIP strategies such as repositioning and mobilization, nutritional supplementation, creams, and co‐interventions effects.
Identification of SARS CoV‐2 Omicron BA.1 and a novel Delta lineage by rapid methods and partial spike protein sequences in Sulaymaniyah Province, Iraq
Authors: Rasheed Mariwan Kadir , Awrahman Harem Abdalla , Amin Al‐Jaf Sirwan M. , Niranji Sherko S. 
Published: March 2023

AbstractBackgroundFive variants of concern (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS CoV‐2) have been globally recorded including Alpha, Beta, Gamma, Delta, and Omicron. The Omicron variant has outcompeted the other variants including the Delta variant. Molecular screenings of VOCs are important for surveillance, treatment, and vaccination programs. This study aimed to identify VOCs by using rapid inexpensive methods and partial sequencing of the virus's spike gene.MethodsMutation‐specific rRT PCR probes were used for both D614G and K417N mutations to potentially discriminate between Delta and Omicron variants. These were followed by sequencing of a fragment of spike gene (748 nucleotides), which covers the most notable VOC mutations in the receptor binding domain of SARS CoV‐2.ResultsRapid methods showed that out of 24 SARS CoV‐2 positive samples, 19 carried the N417 mutation, which is present in the Omicron variant. Furthermore, 3 samples carried K417 wildtype, which is present in the Delta variant. Additionally, 2 samples containing both K417 and N417 suggested mixed infections between the two variants. The D614G mutation was present in all samples. Among the 4 samples sequenced, 3 samples carried 13 mutations, which are present in Omicron BA.1. The fourth sample contained the two common mutations (T478K and L452R) present in Delta, in addition to two more rare mutations (F456L and F490S), which are not commonly seen in Delta. Our data suggested that both Omicron variant BA.1 and a novel Delta variant might have circulated in this region that needs further investigations.
Federated learning‐based colorectal cancer classification by convolutional neural networks and general visual representation learning
Authors: Nergiz Mehmet 
Published: March 2023

AbstractColorectal cancer is the fourth fatal disease in the world, and the massive burden on the pathologists related to the classification of precancerous and cancerous colorectal lesions can be decreased by deep learning (DL) methods. However, the data privacy of the patients is a big challenge for being able to train deep learning models using big medical data. Federated Learning is a rising star in this era by providing the ability to train deep learning models on different sites without sacrificing data privacy. In this study, the Big Transfer model, which is a new General Visual Representation Learning method and six other classical DL methods are converted to the federated version. The effect of the federated learning is measured on all these models on four different data settings extracted from the MHIST and Chaoyang datasets. The proposed models are tested for single learning, centralized learning, and federated learning. The best AUC values of federated learning on Chaoyang are obtained by the Big Transfer and VGG models at 90.77% and 90.76%, respectively, whereas the best AUC value on MHIST is obtained by the Big Transfer model at 89.72%. The overall obtained results of models on all data settings show that the contribution of Federated Learning with respect to single learning is 4.71% and 11.68% for the “uniform” and “label‐biased” data settings of Chaoyang, respectively, and 6.89% for the “difficulty level‐biased” data setting of MHIST. Thus, it is experimentally shown that federated learning can be applied to the field of computational pathology for new institutional collaborations.