bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved Mechanical Properties of EBM Biomedical Co–28Cr–6Mo–0.11N Alloy by the Dispersed Precipitation Control of ε-HCP Phase Based on ε ↔ γ Phase Transformation
Authors: Wang Hao , Miyagi Toshimi , Chiba Akihiko 
Published: August 2023

AbstractMechanical properties of electron-beam-melted biomedical Co–Cr–Mo–N alloys can be improved by the grain refinement from reverse transform treatment, which transforms a low-temperature strong ε-phase into a high-temperature ductile γ-phase. Although mechanical properties of alloys consisting of a single ε- or γ-phase have been previously reported on, those comprising mixed ε- and γ-phases have not yet been investigated. Herein, the heat treatment conditions of the Co–28Cr–6Mo–0.11N alloy were determined to control the phase fraction while obtaining fine grains in the mixed phases with superior mechanical properties. The phase transformation behavior was analyzed. Superior mechanical properties were observed in the mixed phases containing 70 pct γ-phase and 30 pct ε-phase. The tensile and yield strengths were higher, and the elongation was approximately the same, compared to that of the single γ-phase. Moreover, the 30 pct ε-phase mixed-phase material obtained during the γ → ε heat treatment had a smaller overall average grain size and showed superior mechanical properties than that obtained during the ε → γ heat treatment. This study is expected to facilitate the application of biomedical Co–Cr–Mo–N alloys with fine grains and superior mechanical properties obtained via heat treatment.
In silico design, docking simulation, and ANN-QSAR model for predicting the anticoagulant activity of thiourea isosteviol compounds as FXa inhibitors
Authors: Gackowski Marcin , Madriwala Burhanuddin , Koba Marcin 
Published: August 2023

AbstractNovel oral anticoagulants are frequently used for the pharmacotherapy of thromboembolic disorders but still have drawbacks and side effects. While numerous synthetic and semisynthetic derivatives of nontoxic isosteviol possess potential therapeutic properties, including anticoagulant activity. Besides, thiourea is recognized in medicinal chemistry research as a component of a common framework of many drugs or bioactive compounds. The present work combines molecular modeling and docking approach for searching and designing novel thiourea isosteviol-based compounds as potential FXa inhibitors. Elaborated regression model well reflects the relationships between experimentally determined anticoagulant activity and molecular descriptors and may be used for the prediction of FXa inhibitory activity of novel thiourea isosteviol compounds. Among 20 descriptors incorporated into the ANN model, 60% are 2D topological descriptors, 25% describe three-dimensional molecular structure, and remaining 15% belong to constitutional descriptors. Additionally, docking simulation confirms the prominent binding of the newly in silico designed molecules with the active sites of the protein, which may be the lead molecules and can be further optimized for the efficient pharmacodynamic and pharmacokinetic profiles. Based on the results obtained, thiourea derivatives of isosteviol with 3-chloro-4-fluorophenyl, 3-fluoro-4-chlorophenyl or 4-(oxazol-5-yl)phenyl substituent may be promising FXa inhibitors. Findings reported in the present work can be used as valuable information for the development of anticoagulants.
Adrenal and periadrenal schwannoma: histological, molecular and clinical characterization of an institutional case series
Authors: Stenman Adam , Falhammar Henrik , Zedenius Jan , Juhlin C. Christofer 
Published: August 2023

Abstract
Purpose
Adrenal schwannoma (AS) and periadrenal schwannoma (PAS) are exceedingly rare Schwann cell tumors that develop from the adrenal medulla and periadrenal peripheral nerves respectively. The underlying genetic events are elusive.

Methods
We searched our institutional database for AS/PAS cases and reviewed the histology and clinical outcome. Comprehensive molecular work-up was performed.

Results
We found reports of 4 AS/PAS cases diagnosed between 1992 and 2022 among the 1248 adrenal lesions submitted for histopathology during the same time period (0.32%). Two patients were male, two were female, and the age span was 59–80 years. Median size was 70 mm (range 50–100 mm), and from a radiology perspective, the lesions were initially suspected of malignant lesions originating from either adrenals or kidneys. Hormonal analyses were normal in all cases. Histologically, three cases were annotated as cellular AS or PAS, and one case was annotated as microcystic AS. Molecular characterization using focused next-generation sequencing did not identify SMARCB1 or NF2 mutations, alterations previously associated to schwannoma at other anatomical sites. The postoperative period was without complications for all patients, and follow-up did not show any signs of relapse or metastatic disease.

Conclusion
AS/PAS are rare neoplasms that are most often benign, and the molecular etiology is most likely not related to mutations in established schwannoma-related genes. Since these tumors may be misinterpreted as malignant, knowledge of this entity is essential for radiologists, endocrinologists, surgeons and pathologists.
COVID-19 omicron variant outbreak in a hematopoietic stem cell transplant unit
Authors: Gilioli Andrea , Bresciani Paola , Franceschini Erica , Messerotti Andrea , Pioli Valeria , Colasante Corrado , Bettelli Francesca , Giusti Davide , Forghieri Fabio , Morselli Monica , Colaci Elisabetta , Potenza Leonardo , Gennari William , Pecorari Monica , Marasca Roberto , Candoni Anna , Mussini Cristina , Trenti Tommaso , Comoli Patrizia , Luppi Mario , Cuoghi Angela 
Published: August 2023

AbstractRecommendations and guidelines for management of SARS-COV-2 infection in hematologic patients were developed in the very difficult context of dealing with novel viral variants from one pandemic wave to another, with different susceptibility to available drugs and vaccines. Moreover, the largest SARS-COV-2 case series in patients treated for hematologic malignancies, including stem cell transplant recipients, was published before the Omicron surge, and refers mainly to Alpha and Delta viral variants. These infections had very high mortality, in a period when antivirals and monoclonal antibodies were mostly unavailable. Here, we report for the first time a SARS-COV-2 Omicron variant outbreak inside a Bone Marrow Transplant (BMT) Unit, describing the characteristics, clinical course, and infection outcomes shortly before and shortly after myeloablative transplantation. We detail how infections were treated off-label and managed inside the BMT ward, to guarantee the best possible outcomes while avoiding risks for non-infected inpatients. The positive outcomes observed suggest that it may not be absolutely necessary to obtain SARS-CoV-2 PCR negativity before BMT in hematologic patients after treated infection, in cases with long-term PCR positivity and high-risk hematologic disease.
Bifurcation Analysis of Fluid Flows
Authors: Dijkstra Henk A. , Wubs Fred W. 
Published: August 2023

A better understanding of the mechanisms leading a fluid system to exhibit turbulent behavior is one of the grand challenges of the physical and mathematical sciences. Over the last few decades, numerical bifurcation methods have been extended and applied to a number of flow problems to identify critical conditions for fluid instabilities to occur. This book provides a state-of-the-art account of these numerical methods, with much attention to modern linear systems solvers and generalized eigenvalue solvers. These methods also have a broad applicability in industrial, environmental and astrophysical flows. The book is a must-have reference for anyone working in scientific fields where fluid flow instabilities play a role. Exercises at the end of each chapter and Python code for the bifurcation analysis of canonical fluid flow problems provide practice material to get to grips with the methods and concepts presented in the book.
A review of extended coronavirus disease 2019 (COVID-19) isolation duration among inpatients in a tertiary-care hospital—Iowa, 2020–2022
Authors: Abosi Oluchi J. , Trannel Alexandra , Schwartzhoff Patrick , Ackman Mark , Zilles Barbara , Marra Alexandre R. , Dains Angelique , Naito Toshio , Salinas Jorge L. , Diekema Daniel J. , Hanna Beth , Murphy Jaime P. , Wellington Melanie , Brust Karen , Kobayashi Takaaki 
Published: August 2023

AbstractOf the 2,668 patients admitted with coronavirus disease 2019 (COVID-19), 4% underwent prolonged isolation for >20 days. Reasons for extended isolation were inconsistent with Centers for Disease Control and Prevention (CDC) guidelines in 25% of these patients and were questionable in 54% due to an ongoing critically ill condition at day 20 without CDC-defined immunocompromised status.
Making a Trade of Preaching: Clergy, Labor, and Political Economy between the Interregnum and Restoration
Authors: Brown Simon 
Published: August 2023

AbstractMany writers of political economy in the 1660s and 1670s agreed that there were too many clergy and divinity students in England. This surplus of ministers and aspiring clerics, they argued, would better contribute to the public if they worked as productive laborers in agriculture and manufacturing. The question of whether preaching constituted labor had been a contentious theological debate in the late years of the Interregnum, and the proposals advanced by commentators like William Petty and Edward Chamberlayne to put ministers to other work assumed that clergy were comparable to profane professionals who labored for their keep. This article traces how this fraught question continued to confront schemes of political economy that otherwise sought to avoid religious controversy. In the 1670s, Christopher Wase responded to calls to limit clergy and free schools with an innovative survey and arguments drawn from empirical evidence, scriptural exegesis, and economic principles. Wase was one among other contemporaries who assigned a productive place for learning despite its irreducibility to a form of labor. His efforts thereby elevated the status of the clergy on a foundation of economic premises arrived at through engagement in theological debate.
Duality theory for exponential utility-based hedging in the Almgren–Chriss model
Authors: Dolinsky Yan 
Published: August 2023

AbstractIn this paper we obtain a duality result for the exponential utility maximization problem where trading is subject to quadratic transaction costs and the investor is required to liquidate her position at the maturity date. As an application of the duality, we treat utility-based hedging in the Bachelier model. For European contingent claims with a quadratic payoff, we compute the optimal trading strategy explicitly.
LUCRETIUS’ RAZOR ON EPICURUS’ ATOMIC THEORY
Authors: Corrado Alberto 
Published: August 2023

AbstractThis article investigates why Lucretius does not dedicate any section of his poem to atomic size or provide a technical term to describe the concept. This absence is particularly significant because Epicurus’ Letter to Herodotus both uses the term μέγεθος to indicate atomic size and contains a passage reporting specifically on this property. First, the article argues that atomic size and shape are causally redundant in Epicurus’ ontology. Second, it demonstrates that the origin of both shape and size is found in the smallest magnitudes in Epicurean physics, the minima. Drawing on these findings, it concludes that, since atomic size violates the law of parsimony, it is a superfluous entity in the Epicurean system. After analysing passages from the De rerum natura, it suggests that the absence of atomic size in Lucretius may be deliberate. Lucretius’ microphysics works perfectly without introducing a philosophical notion of atomic size, and is more economical and efficient than that of Epicurus.
Families with young children in homeless shelters: Developmental contexts of multisystem risks and resources
Authors: Cutuli J. J. , Herbers Janette E. , Vrabic Sarah C. , Baye Omari 
Published: August 2023

AbstractWe apply a multisystem perspective to three aims relevant to resilience for young children in emergency and transitional homeless shelters. We consider profiles of risks and resources before shelter, early childhood program enrollment during shelter, and the likelihood of returning to shelter or having a subsequent child welfare placement. We used longitudinal, city-wide data from multiple sources integrated at the individual level across the lifespan for 8 birth cohorts. Young children (N = 1,281) stayed in family shelters during an 18-month period during a multisystem intervention. Risk factor rates were high as were rates of early childhood program enrollment (66.1% in any program; 42.3% in a high-quality program), which may suggest positive effects of the multisystem intervention. Multilevel latent class analysis revealed four profiles, considering prior shelter stays, prior child welfare placements, prior elevated lead levels, perinatal factors (teenage mother, prenatal care, low maternal education, and poor birth outcomes), demographics, and early childhood program enrollment and quality. One profile with higher rates of child welfare placement before the shelter stay and considerable enrollment in high-quality early childhood programs corresponded to lower rates of subsequent child welfare placement. Profiles did not differ on the likelihood of returning to shelter.
Actin-mediated endocytosis in the E-YSL helps drive epiboly in zebrafish
Authors: Cheng Jackie C. , Miller Andrew L. , Webb Sarah E. 
Published: August 2023

SummaryIn zebrafish, a punctate band of F-actin is reported to develop in the external yolk syncytial layer (E-YSL) during the latter part of epiboly in zebrafish embryos. Here, electron microscopy (EM) and fluorescence confocal microscopy were conducted to investigate dynamic changes in the E-YSL membrane during epiboly. Using scanning EM, we report that the surface of the E-YSL is highly convoluted, consisting of a complex interwoven network of branching membrane surface microvilli-like protrusions. The region of membrane surface protrusions was relatively wide at 30% epiboly but narrowed as epiboly progressed. This narrowing was coincident with the formation of the punctate actin band. We also demonstrated using immunogold transmission EM that actin clusters were localized at the membrane surface mainly within the protrusions as well as in deeper locations of the E-YSL. Furthermore, during the latter part of epiboly, the punctate actin band was coincident with a region of highly dynamic endocytosis. Treatment with cytochalasin B led to the disruption of the punctate actin band and the membrane surface protrusions, as well as the attenuation of endocytosis. Together, our data suggest that, in the E-YSL, the region encompassing the membrane surface protrusions and its associated punctate actin band are likely to be an integral part of the localized endocytosis, which is important for the progression of epiboly in zebrafish embryos.
Anti-Japanism as a strategy for reshaping national identity in post-liberation South Korean fictions (1945–1948)
Authors: Kang Jeonggu 
Published: August 2023

AbstractThis article argues that South Koreans' anti-Japanism in the post-liberation period can be regarded as an ideological construction, which was inevitably required to reshape their national identity, rather than as a reasonable and serious critical consideration of colonial Japan. Anti-Japanism functions as an identification framework in an era when Koreans needed to develop a new discourse which reflects the rapid politico-socio-cultural changes of that period. Under military control of the United States and the Soviet Union, Koreans made Japan the other in a number of ways in order to unite their nation state and national identity, relying specifically on racial difference and hierarchy. First, Korean intellectuals, who once cooperated with colonial Japan in the political sphere or in their ordinary lives, explicitly revealed their anti-Japanese sentiments in their writings right after liberation. Second, after liberation, anti-Japanism emerged from a process that Koreans would exploit, after demarcating the moral difference between themselves and the remaining Japanese migrants, to exclude the Japanese from their community. Finally, anti-Japanism in the post-liberation period can be detected in Koreans' tenacious attitude, as they tacitly restricted the articulation of filial or cultural hybridity with the Japanese people in order to reconfigure their national identity.
Experimental Evidence for a Weak Calcic‐Amphibole‐Rich Deep Crust in Orogens
Authors: Wang X. , Zhang J. F. , Tommasi A. , Lopez‐Sanchez M. A. , Jing Z. C. , Shi F. , Liu W. L. , Barou F. 
Published: August 2023

AbstractAmphibole‐rich rocks constitute significant components of the mid‐ to lower continental crust, particularly in active orogens characterized with thick and hot crusts. Nevertheless, experimental data on their viscosity remain scarce. We conducted axial compression deformation experiments on synthetic amphibolites under temperature and pressure conditions resembling deep sections of overthickened crust. A novel flow law for a calcic‐amphibole‐rich rock (80% amphibole +20% garnet) in the dislocation creep regime is derived from these experiments. Contrary to common assumptions, our results reveal that calcic‐amphibolite is 1‐2 orders of magnitude weaker than plagioclase‐rich amphibolite, granulite, or gabbro. A calcic‐amphibole‐rich, low viscosity deep crust may not only support the “channel flow” model proposed for the Tibetan Plateau but also explain the observed high crustal seismic anisotropy in the region.
Sea Ice Formation, Glacial Melt and the Solubility Pump Boundary Conditions in the Ross Sea
Authors: Loose Brice , Stammerjohn Sharon , Sedwick Peter , Ackley Stephen 
Published: August 2023

AbstractSeasonal formation of Dense Shelf Water (DSW) in the Ross Sea is a direct precursor to Antarctic Bottom Water, which fills the deep ocean with atmospheric gases in what composes the southern limb of the solubility pump. Measurements of seawater noble gas concentrations during katabatic wind events in two Ross Sea polynyas reveal the physical processes that determine the boundary value properties for DSW. This decomposition reveals 5–6 g kg−1 of glacial meltwater in DSW and sea‐ice production rates of up to 14 m yr−1 within the Terra Nova Bay polynya. Despite winds upwards of 35 m s−1 during the observations, air bubble injection had a minimal contribution to gas exchange, accounting for less than 0.01 μmols kg−1 of argon in seawater. This suggests the slurry of frazil ice and seawater at the polynya surface inhibits air‐sea exchange. Most noteworthy is the revelation that sea‐ice formation and glacial melt contribute significantly to the ventilation of DSW, restoring 10% of the gas deficit for krypton, 24% for argon, and 131% for neon, while diffusive gas exchange contributes the remainder. These measurements reveal a cryogenic component to the solubility pump and demonstrate that while sea ice blocks air‐sea exchange, sea ice formation and glacial melt partially offset this effect via addition of gases. While polynyas are a small surface area, they represent an important ventilation site within the southern‐overturning cell, suggesting that ice processes both enhance and hinder the solubility pump.
Application of the Observation‐Oriented CNOP‐P Sensitivity Analysis Method in Evapotranspiration Simulation and Prediction Over the Tibetan Plateau
Authors: Sun Guodong , Mu Mu , Zhang Qiyu , Ren Qiujie , You Qinglong 
Published: August 2023

AbstractTo improve the ability to accurately simulate and predict evapotranspiration (ET) over the Tibetan Plateau (TP), an observation‐oriented sensitivity analysis (SA) method based on a conditional nonlinear optimal parameter perturbation (CNOP‐P) method is employed. With the observation‐oriented CNOP‐P SA method, a sensitive parameter subset among all parameters is first determined through comparison with observations of ET across the TP. Then, the sensitive parameter combination is optimized to evaluate the ET simulation ability and prediction skill over the TP. A traditional one‐at‐a‐time (OAT) method is also employed, and the results are compared with the numerical results obtained with the observation‐oriented CNOP‐P SA method. The results show that the identified parameter combination using the observation‐oriented CNOP‐P SA method is more sensitive than that using the OAT method for the estimation of ET at 13 sites on the TP. The above results demonstrate that it is important to determine the sensitive parameter combination using the observation‐oriented SA method to improve the ET simulation ability and prediction skill over the TP.
Passive Microwave Radiometry at Different Frequency Bands for River Discharge Retrievals
Authors: Brakenridge G. Robert , Nghiem Son V. , Kugler Zsofia 
Published: August 2023

AbstractThe present era of climate change and expanding population requires major improvements in sustained observation of global river discharge. Floods and droughts are affecting food supplies, and suspected long‐term trends require appropriate data for evaluation. Orbital remote sensing can address this observational need. Here we use satellite Ka‐ (36.5 GHz) and L‐band (1–2 GHz) passive microwave radiometry (PMR) to monitor river discharge changes and determine what size rivers can be measured and the frequencies and polarization configurations that yield the most robust results. Selected satellite gauging reaches (SGRs) can be measured at near‐daily intervals from 1998 to present (Ka‐band) and 2010 to present (L‐band). The SGRs are 10–36 km in length; the dynamic proportion of water surface area within each varies with river discharge. Due to contrasting dielectric properties, water and land emit different intensities of microwave radiation; thus emission from a mixed water/land pixel decreases as the proportion of water within the pixel increases. Depending on the river and floodplain morphology, water flow area can be a robust indicator of discharge and the microwave sensors can retrieve daily discharge to ±20%. Instead of spatial resolution, it is the sensor measurement precision, geolocation accuracy, and channel and floodplain morphology that most strongly affect accuracy. Calibration of flow area signals to discharge can be performed using nearby ground stations (even if now discontinued) or by comparison to hydrologic modeling.