bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival of the fittest: do firms actively or passively learn survival?
Authors: Naz Farah , Kunwar Mehma , Alam Atia , Lutfullah Tooba 
Published: May 2023

PurposeIn the corporate world, there is no certainty of survival. This research aims to identify firm-level factors that increase or decrease a firm's probability of exit and survival.Design/methodology/approachThe study examines 153 listed textile sector firms in Pakistan over a 10-year period from 2009 to 2018, comprising 1,413 observations. The semi-parametric Cox regression model is used to process the results.FindingsThe study finds that larger and exporting firms are more likely to survive, while those with a high ratio of fixed assets to total assets, high expenditure on advertising and variable costs are less likely to survive. The relationship between age and firm survival is inconclusive.Research limitations/implicationsAdaptability to the external environment provides a competitive advantage that is crucial for textile firms to reduce their chances of exit. The research is valuable for strategic managers and policymakers to identify focus areas to prevent firm exit.Originality/valueThis study supports the active learning theory, which suggests that new entrants in the textile sector of Pakistan should focus on becoming active market players, increasing efficiency and reducing variable costs to survive.
The influence of return channel type on the relationship between return service quality and customer loyalty in omnichannel retailing
Authors: Xie Chaohong , Gong Yeming , Xu Xianhao , Chiang Chung-Yean , Chen Qian 
Published: May 2023

PurposeThis study investigates the impacts of return channel type on the relationships between return service quality (RSQ) and customer loyalty (CL) in an omnichannel retailing environment.Design/methodology/approachData comes from Chinese customers having a return experience in omnichannel retailing that uses the channel type of both buy-online-return-in-store (BORIS) and buy-in-store-return-to-online warehouses (BSROW). The authors use the structural equation modeling to test the hypotheses and the bootstrapping method to test the mediation and moderation effect.FindingsFor BORIS channel, satisfaction of customer returns (CRS) partially mediates the relationship between convenience and CL, and fully mediates that between CL and responsiveness, transparency and competence, respectively. For BSROW channel, CRS partially mediates the relationship between responsiveness and CL, and fully mediates that between CL and convenience, transparency and competence, respectively. The mediation effects indicate that omnichannel customers may feel more satisfied due to higher omnichannel fulfillment (responsiveness and convenience) and omnichannel trust (transparency and competence) provided by retailers. Return channel type moderates the relationship between RSQ-convenience and CL. The results show the different expectations between BORIS and BSROW customers in the return process.Research limitations/implicationsThis paper serves as a pioneering study to apply cognition-affect-behavior paradigm into the field of return management in omnichannel retailing.Practical implicationsThe findings suggest retailers develop their strategies on customer returns and post-sales service quality improvement in the omnichannel. Also, retailers should develop an integrated return system across channels to provide convenient service to BORIS customers and quick response to BSROW customers.Originality/valueStudying return service management in the omnichannel from customer's cognition appraisal, this study contributes to the literature of the reverse service management by bringing in the effect of omnichannel type to explore the relationship between RSQ and CL.
Andrew Voyce: a living tribute. “You can end up in a happy place.”
Authors: Carson Jerome 
Published: May 2023

Purpose
The main aim of this paper is to provide a living tribute of lived expert by experience and researcher Andrew Voyce.

Design/methodology/approach
Andrew provided the author with a list of names of people he might approach to write a tribute on his behalf.

Findings
The accounts describe the influence that Andrew has had both as an educator and as a trusted colleague for the people approached.

Research limitations/implications
In many ways, the voices of people with mental health problems have been marginalised. Few mental health journals, with only some exceptions, encourage lived experience contributions.

Practical implications
The mental health agenda continues to be dominated by professional groups. The remarkable individuals who continually battle with serious mental illness are often lost in official discourses.

Social implications
Despite the fact that the topic of mental health is now much more in the public domain, research tells us that the most effective anti-stigma strategy is contact with sufferers.

Originality/value
The archivist Dr Anna Sexton co-produced one of the few mental health archives that only featured people with lived experience. Andrew was one of the four people featured in it. This account “showcases” the work of this remarkable man.
Measuring food‐energy‐water nexus footprint using a systematic input–output approach: A case study of Pune district
Authors: Mukhopadhyay Kakali , Prabhu Vishnu S. , Shrivastava Shraddha , Ajatasatru Ananya , Klauer Bernd 
Published: May 2023

AbstractThe advent of climate change with the recognition of interlinkages between Food‐Energy‐Water (FEW) resource security has brought forth a renewed emphasis on ascertaining the FEW footprints of varied policy interventions. The nexus approach through an IO framework explores the interplays and synergies between sectoral flows and their FEW footprints. India is currently undergoing great transformations under policy interventions on both the economic and environmental front. The country has been attracting investments to expand its manufacturing base, while also aiming to transition into a greener economy. The district of Pune has a balanced and diversified economic profile, spread across manufacturing, as well as knowledge‐based tertiary sectors. However, rapid urbanization has put an undue burden on its FEW resources, challenging urban sustainability. Hence cohesive strategies are of priority to ensure sustainable and equitable development. Toward this end, the current study presents the first‐ever district‐level economy‐wide FEW nexus study in India. Results indicate that the most resource‐intensive sectors in Pune district include the food processing sector, motor vehicles, and electrical engineering and instruments. Based on this comprehensive footprint analysis, priority sectors are identified to pursue sector‐wise efficiency analysis.
Preauricular sulcus: Radiological incidence in the female gender in a multicultural population
Authors: Lim Lincoln J , Shannon Roland , Kyi Sonya , Tomlinson Heath 
Published: May 2023

AbstractIntroductionThe preauricular sulcus is a bony groove seen on the inferior aspect of the iliac bone. It is thought and accepted to be an indicator of female gender. To our knowledge, this study would be the first to examine the sulcal incidence in a multicultural population. To date, there are limited studies to also test the existing hypothesis that the sulcus is only seen in the female gender. The results of this study would be applicable to the field of forensic medicine and gender identification in the post‐mortem setting.MethodsRetrospective review of 500 adult pelvic X‐ray radiographs (250 female and 250 male) obtained as part of routine medical care in a metropolitan public health service (encompassing three hospitals) was performed. The radiographs were examined by two post‐FRANZCR examination senior registrars who recorded their results independently.ResultsThe mean age of the female population was 70.1 years, and the mean age of the male population was 75.5 years. This study found that the preauricular sulcus is only present in the female pelvis. The incidence was 41.2% (103 of 250) in the examined female patient population. The sulcal incidence in this study was also found to be significantly higher than previously reported in prior studies.ConclusionThis study supports the previous notion that the presence of preauricular sulcus in a pelvic specimen would indicate the female gender. The absence of the sulcus does not necessarily confer the male gender.
Limited evidence for species‐specific sensitivity of temperature‐dependent fractionation of oxygen stable isotope in biominerals: A meta‐analysis
Authors: Morissette Olivier , Trueman Clive N. , Sturrock Anna M. , Geffen Audrey J. , Shirai Kotaro 
Published: May 2023

Abstract

Water temperature is key to the study of aquatic ectotherm ecology, but precise measurements of individual‐based thermal experience remain difficult to validate. The stable isotope composition of oxygen in biominerals acts as a natural thermometer due to the temperature dependence of isotopic fractionation between water and mineral phases. Coefficients of published temperature‐dependent fractionation equations, however, vary among taxa (the so‐called ‘vital effect’) without apparent consistent predictors, implying that species‐specific experimental validation may be needed before inferring temperature from biomineral oxygen isotope thermometry.

Here, we describe a meta‐analysis conducted to assess the influence of biological and experimental sources of variation on the coefficients of published isotope thermometry equations.

We observed that the thermal sensitivity (equation slope) was resistant to any biological or experimental factors, while the isotopic spacing between water and biomineral (equation intercept) showed consistent variation. Experimental conditions and phylogeny were the two main sources of variation in equation coefficients, where experiment approaches influenced both equation intercepts and the fit of the linear regression.

Our results suggest that the use of common equation slopes and generalized taxa‐specific equation intercepts may be appropriate under some circumstances. We additionally suggest that processes related to oxygen balance and osmoregulation may influence equation intercepts, and suggest further experimental work in this area. Finally, our observations provide ground for improvement for future design and reporting of biomineral thermometry experiments.
Cooling streams with riparian trees: Thermal regime depends on total solar radiation penetrating the canopy
Authors: Davies‐Colley Robert J. , Payne George W. 
Published: May 2023

AbstractRiparian planting is often recommended for stream restoration, notably to mitigate solar heating of stream waters. However, plant leaves shade photosynthetically active radiation (PAR, 400–700 nm) more efficiently than the near‐infrared (NIR, 700–3000 nm) wavelengths that comprise about half of incident solar radiation and so contribute equally to water heating. Total solar radiation (NIR + PAR) exposure at the reach scale is needed to avoid bias when predicting the thermal response of streams. In this article, we alert stream ecologists and riparian restorers to the water heating contribution of NIR and provide a means to account for both NIR and PAR in total solar radiation penetrating riparian canopies. We used spectral pyranometers to simultaneously measure total solar radiation and its NIR component under different tree canopies over a wide range of shade conditions as indexed by PAR exposure. Measurements were made during full overcast (diffuse lighting) conditions so as to ‘sample’ transmission of radiation through the complete canopy. The NIR proportion of sub‐canopy solar radiation increased steadily with increasing shade and was appreciably greater under willow than pine canopies, while NZ native broadleaf rainforest had intermediate (rather variable) NIR content. Our trend lines for different tree canopies permit total sub‐canopy solar radiation to be estimated from PAR exposure for unbiased modelling of stream thermal regimes.
The effects of chelation on the intratubular penetration depth of mineral trioxide aggregate
Authors: Teoh Yu‐Yao , Liew Khai Yi , Siao Jethro , Wong Shaun , Chandler Nicholas , Bogen George 
Published: May 2023

AbstractThe penetration depth and extent of mineral trioxide aggregate (MTA) crystallisation into dentinal tubules at 2, 4 and 6 weeks after chelation and MTA obturation were investigated. Standardised 12 mm human root specimens (45) were prepared with NiTi rotary files using 4% NaOCl irrigation. They were randomly allocated to three irrigants (n = 15: 4% NaOCl, 15% ethylenediaminetetraacetic acid or Edgemix) and obturated with sodium fluorescein tagged ProRoot MTA. One millimetre thick apical, middle and coronal sections were examined using confocal laser scanning microscopy to determine MTA penetration depth and area. Depths varied from 352 to 1821 μm at 6 weeks depending on section level and were unaffected by chelation. No differences (p > 0.05) were found in mean maximum penetration depth or dentine area (%) between the 3 irrigants at all time intervals. MTA mineralisation penetrated up to 90% of dentinal tubules and can extend to the cementum in roots with patent, non‐infected tubules.
Analgesic stewardship in Australian residential aged care facilities: Retrospective audit of a collaborative approach to optimising opioid use
Authors: McDerby Nicole , Dawda Paresh 
Published: May 2023

AbstractObjectiveTo evaluate retrospectively an analgesic stewardship role of a non‐dispensing pharmacist as part of a general practice team providing primary care services to residential aged care facilities (RACF).MethodsOur general practice implemented an analgesic stewardship program to optimise and monitor opioid usage for our patients located across 12 RACF in Canberra from March 2019 to September 2020. The primary objective was the development of a multidisciplinary chronic pain care plan to document treatment and monitoring strategies for optimising pain control. The pharmacist reviewed and documented existing pain management strategies in a care plan for each patient and discussed recommendations for optimisation with the general practitioner. The general practitioner implemented accepted recommendations and distributed finalised care plans to the RACF. A retrospective audit of care plans was undertaken to assess the outcomes: mean daily oral morphine equivalence to monitor opioid usage, and pain scores to monitor for any potential harm associated with analgesic stewardship.ResultsOne hundred and sixty‐seven residents received an initial care plan. Residents were scheduled for a follow‐up care plan after 6 months, which was achieved for 100 residents (60%). Scope for optimising opioid therapy was identified for 47 residents (28%) at baseline and 23 residents (23%) at follow‐up. Mean opioid usage and pain scores were reduced at follow‐up; 19.4 mg (SD 40.8) versus 13.4 mg (SD 22.8), and 4.2 (SD 2.3) versus 3.9 (SD 2.0), respectively.ConclusionsA systematic, multidisciplinary analgesic stewardship approach may optimise pain management plans and reduce opioid usage in RACF residents.
Retinal vascular structure independently predicts the initial treatment response in neovascular age‐related macular degeneration
Authors: Leth‐Møller Christensen Kathrine , Kristjansen Ditte Borup , Vergmann Anna Stage , Torp Thomas Lee , Peto Tunde , Grauslund Jakob 
Published: May 2023

AbstractPurposePrediction of the early treatment response is important in neovascular age‐related macular degeneration (nAMD). Hence, we aimed to test if non‐invasive measurements of the retinal vascular structure were able to predict a successful outcome of initial intravitreal treatment.MethodsIn 58 eyes of 58 patients with treatment‐naïve nAMD, advanced markers of retinal vascular structure were measured by Singapore I Vessel Assessment prior to initial intravitreal treatment with three monthly injections of aflibercept with subsequently categorization of patients as full treatment responders (FTR) or non/partial treatment responders (N/PR), with the former defined as loosing fewer than five Early Treatment Diabetic Retinopathy Study letters and having no residual intra‐ or subretinal fluid or macular haemorrhage.ResultsOf 54 eyes attending follow‐up, 44.4% were categorized as FTR. Patients with FTR were older (81.5 vs. 77 years, p = 0.04), and prior to treatment those eyes had a lower retinal arteriolar fractal dimension (Fd) (1.21 vs. 1.24 units, p = 0.02) and venular length‐diameter ratio (LDR) (7.3 vs. 15.9 units, p = 0.006), but did not differ with respect to other retinal vascular parameters. In multiple logistic regression models, a lower chance of FTR was independently predicted by a higher retinal venular LDR (odds ratio [OR] 0.91, 95% CI 0.82–0.99, p = 0.03, for each 1 unit increment) and marginally by a higher retinal arteriolar Fd (OR 0.83, 95% CI 0.68–1.00, p = 0.05, for each 0.01 unit increment).ConclusionRetinal venular LDR independently predicted the initial treatment response in nAMD. If confirmed by long‐term, prospective studies, this might help to guide treatment.
CHMP4A stimulates CD8+ T‐lymphocyte infiltration and inhibits breast tumor growth via the LSD1/IFNβ axis
Authors: Song Songze , Zhang Deyu , Chen Jingyi , Qi Lin , Zhang Mengting , Yang Xiao , Ye Tianxing , Ye Qinong , Lin Jing 
Published: May 2023

AbstractCD8+ T lymphocyte‐mediated immunity strategies have represented attractive weapons against breast cancer (BC) recently. However, the mechanisms underlying CD8+ T‐lymphocyte infiltration still remain obscure. Here, using bioinformatics analysis, we identified four hub prognostic genes related to CD8+ T‐lymphocyte infiltration (CHMP4A, CXCL9, GRHL2, and RPS29), among which CHMP4A was the most significant gene. High CHMP4A mRNA expression was significantly associated with longer overall survival (OS) in BC patients. Functional experiments showed that CHMP4A had the ability to promote CD8+ T‐lymphocyte recruitment and infiltration and suppressed BC growth in vitro and in vivo. Mechanistically, CHMP4A stimulates CD8+ T‐lymphocyte infiltration by downregulating LSD1 expression, leading to HERV dsRNA accumulation, and promoting IFNβ and its downstream chemokine production. Collectively, CHMP4A is not only a novel positive predictor for prognosis in BC but also a stimulator of CD8+ T‐lymphocyte infiltration regulated by the LSD1/IFNβ pathway. This study suggests that CHMP4A may be a novel target for improving the effectiveness of immunotherapy in patients with BC.
Scalable preparation of osteogenic micro‐tissues derived fromhESC‐derived immunity‐and‐matrix‐regulatory cells within porous microcarriers in suspension culture
Authors: Ma Huike , Gao Tingting , Wang Liu , Mohsin Ali , Hao Jie , Guo Meijin , Wu Jun 
Published: May 2023

AbstractBone defects (BDs), a prevalent clinically refractory orthopaedic disease, presently have no effective treatments. Mesenchymal stem cells (MSCs) can differentiate into osteoblasts and serve as potential seed cells for bone tissue engineering for BD treatment. However, the feasibility of using MSCs as seed cells for bone tissue engineering remains unclear. As a result, the critical issue of large‐scale cell‐scaffold preparation remains unresolved. In this study, we demonstrated for the first time that human embryonic stem cell‐derived MSCs, also known as immunity‐and‐matrix‐regulatory cells (IMRCs), could be inoculated into microcarriers to create osteogenic micro‐tissues appropriate for scalable production in 250 mL bioreactor. IMRCs were generally smaller than umbilical cord‐derived MSCs (UCMSCs) and could attach, migrate, proliferate and differentiate within the porous microcarriers, whereas UCMSCs could only attach to the surface of microcarriers. Osteogenic micro‐tissues generated from IMRCs‐seeded microcarriers significantly increased osteocalcin levels after 21 days of differentiation in a bioreactor. Furthermore, the expression levels of osteogenic biomarker genes/proteins such as alkaline phosphatase (ALP), osteocalcin (OCN), runt‐related transcription factor 2 (RUNX2), osteopontin (OPN) and osterix (OSX) were significantly higher than osteogenic micro‐tissues derived from UCMSCs‐seeded microcarriers. Our findings imply that IMRCs could potentially serve as seed cells for the scalable production of osteogenic micro‐tissues for BD treatment.
Ex vivo factor VIII‐modified proliferating human hepatocytes therapy for haemophilia A
Authors: Zhang Kun , Wu Ning , Cen Jing , Li Jie , Wang Zhen , Xia Qiang , Hui Lijian 
Published: May 2023

AbstractEx vivo gene manipulation in human hepatocytes is a promising therapeutic strategy in the treatment of inherited liver diseases. However, a major limitation is the lack of a highly efficient and safe genetic manipulation system for transplantable primary human hepatocytes (PHHs). Here, we reported that proliferating human hepatocytes (ProliHHs) cultured in vitro showed high susceptibility to lentivirus‐mediated genetic modification and maintained cellular phenotypes after lentiviral infection. Human factor VIII expression was introduced through F8‐Lentivirus‐mediated transduction of ProliHHs followed by xenotransplantation into immunocompromised haemophilia A mice. We demonstrated that these F8‐modified ProliHHs could effectively repopulate the mouse liver, resulting in therapeutic benefits in mouse models. Furthermore, no genotoxicity was detected in F8‐modified ProliHHs using lentiviral integration site analysis. Thus, this study demonstrated, for the first time, the feasibility and safety of lentiviral modification in ProliHHs to induce the expression of coagulation factor VIII in the treatment of haemophilia A.
Prominent para‐cardiac fat mimicking left atrial appendage thrombus on echocardiography: Utility of cardiac computed tomography
Authors: Honnekeri Bianca , Fava Agostina M. , Reyaldeen Reza , Kanj Mohamed , Alvarez Paulino , Xu Bo 
Published: May 2023

AbstractTransesophageal echocardiography is the most frequently used imaging modality for exclusion of left atrial appendage thrombus prior to cardioversion. Echocardiographers should be aware of rare conditions that may mimic left atrial appendage thrombus. Here, we describe a rare case of prominent para‐cardiac fat mimicking left atrial appendage thrombus on transesophageal echocardiographic imaging. Multimodality imaging with cardiac computed tomography was instrumental in providing further anatomical delineation and characterization of the echodensity as prominent para‐cardiac fat in this case.