bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with adolescents' perception of four types of domestic violence in Honduras/Central America during the COVID-19 pandemic.
Authors: Espinoza-Turcios Eleonora , Sosa-Mendoza Carlos Antonio , Zambrano Lysien Ivania , Chinchilla-Castañeda Kathya , Castro-Ramos Henry Noel , Armada-Pacheco José , Mejia Christian R. 
Published: May 2023

Abstract
Introduction: The confinement measures applied during the pandemic brought as a consequence an increase in domestic violence, this problem has not been investigated from the perspective of adolescents in Central America.
Objective: To determine the factors associated with adolescents' perception of four types of domestic violence in Honduras during the COVID-19 pandemic.
Methodology: Cross-sectional analytical study, secondary database, inquired about the perception of four types of domestic violence during the highest peak of the first wave of the pandemic. A multivariate analysis including socio-familial variables was performed, and descriptive and analytical results were obtained.
Results: Of the 3272 young people surveyed, verbal violence was associated with a basic educational level (p<0.001), alcohol consumption (p<0.001) and that the father (p=0.040), mother (p<0.001) or siblings (p<0.001) had suffered violence at home. For psychological violence, the father (p=0.031), the mother (p<0.001) or the siblings (p<0.001) had suffered domestic violence. For physical violence, basic education level (p=0.002), the father (p=0.005), the mother (p<0.001) or the siblings (p<0.001) had suffered violence at home. Sexual violence was associated with drug use in the last six months (p<0.001).
Discussion: Multiple associations were found with four types of violence perceived by adolescents, which should serve to generate psychological support programs for this group, which has problems due to the stage of life they are in.
Conclusion: Honduran adolescents were exposed to four types of violence in the first wave of the COVID-19 pandemic. Among the associated factors were educational level, alcohol and other drug consumption, and a history of violence in the first degree of consanguinity.
Coexistence of native and invasive species: The case of the critically endangered pygmy raccoon from Cozumel Island
Authors: Lara-Godínez Sofía Ana Lucrecia , Valenzuela-Galván David , González-Romero Alberto , Cuaron Alfredo D. , Sosa Vinicio J. , Vázquez Luis Bernardo 
Published: May 2023

Abstract
Given the growing anthropogenic disturbances of habitats, species are facing several threats and this makes it very important to know the impact of these disturbances on the presence of species. Our objective was to understand the patterns and drivers of the spatial use of the pygmy raccoon Procyon pygmaeus, a carnivore endemic to Cozumel Island and considered critically endangered with extinction. Considering that the loss and fragmentation of natural habitats in Cozumel has increased in recent decades and with this, a greater presence of feral dogs on inland areas of the island has also been evident, we used multi-seasonal single-species occupancy models to assess the effect of two variables on pygmy raccoon activity: a) the type and degree of habitat disturbance and b) the interactions between potentially competing and also endemic species (dwarf coati Nasua nelsoni and common opossum Didelphis virginiana cozumelae) and an invasive predator (feral dog, Canis lupus familiaris). Additionally, we compare the temporal patterns of the activity of the studied species. We found a difference in the probability of detection of the pygmy raccoon throughout the years, and the type of habitat was driving the probability of occupancy of the pygmy raccoon. The overlap between the temporal activity patterns of the pygmy raccoon and the competing species was high, while it was low with that of the invasive predator, the dog, which showed a pattern almost entirely diurnal. We found that habitat disturbance or the presence of dogs on the island has not yet reached a sufficient threshold to negatively impact the spatial use patterns of the pygmy raccoon. but we consider that these scenarios might change dramatically if disturbance or the presence of dogs increases in habitats with a higher presence of pygmy raccoon. Our results have relevant implications for understanding its ecological requirements and limitations and for planning actions for its conservation.
Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer
Authors: Trinidad Camille , Pathak Harsh , Cheng Shibo , Tzeng Shin-Cheng , Madan Rashna , Sardiu Mihaela , Bantis Leonidas , Deighan Clayton , Jewell Andrea , Zeng Yong , Godwin Andrew 
Published: May 2023

Abstract
High grade serous ovarian carcinoma (HGSOC) accounts for ~ 70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since most HGSOCs typically arise from the fallopian tubes (FT), our biomarker search focused on proteins found on the surface of extracellular vesicles (EVs) released by both FT and HGSOC tissue explants and representative cell lines. Using mass spectrometry, 985 EV proteins (exo-proteins) were identified that comprised the FT/HGSOC EV core proteome. Transmembrane exo-proteins were prioritized because these could serve as antigens for capture and/or detection. With a nano-engineered microfluidic platform, six newly discovered exo-proteins (ACSL4, IGSF8, ITGA2, ITGA5, ITGB3, MYOF) plus a known HGSOC associated protein, FOLR1 exhibited classification performance ranging from 85–98% in a case-control study using plasma samples representative of early (including stage IA/B) and late stage (stage III) HGSOCs. Furthermore, by linear combination of IGSF8 and ITGA5 based on logistic regression analysis, we achieved a sensitivity of 80% (99.8% specificity). These lineage-associated exo-biomarkers have potential to detect cancer while localized to the FT when patient outcomes are more favorable.
Diversity, prevalence and virulence of Colletotrichum species causing anthracnose on cassava leaves in the northern region of Brazil
Authors: Machado Stella de C. S. , Veloso Josiene S. , Câmara Marcos P. S. , Vieira Willie A. S. , Castlebury Lisa A , Amaral Ana Gabriele Gurgel , Jumbo Luis O Viteri , Oliveira Eugenio E , Santos Gil 
Published: May 2023

Abstract
Cassava (Manihot esculenta Crantz), is a staple crop widely cultivated by small farmers in developing countries. However, despite the low required level of technology required for its management, it can be affected by several diseases, with anthracnose as the main threat. There is little information about the main species of Colletotrichum that infect cassava in Brazil. Thus, the objective of this work was to study the diversity, prevalence and virulence of Colletotrichum species that cause anthracnose in cassava leaves in northern Brazil. Twenty municipalities of Pará and Tocantins states were selected and leaves with symptoms were collected in those locations. Pure cultures were isolated in the laboratory. Species were identified using phylogenetic analyses of multiple loci and their pathogenicity, aggressivity and virulence levels were assessed. Our results found a greatest diversity of Colletotrichum associated with anthracnose in cassava plants of the “Formosa” cultivar on Tocantins and Pará states. We determined the presence of Colletotrichum chrysophilum, C. truncatum, C. siamense, C. fructicola, C. plurivorum, C. musicola and C. karsti; with C. chrysophilum as the most aggressive and virulent. Our findings provide accurate identifications of species of Colletotrichum causing anthracnose in cassava crops and provide important information for a more effective control of this disease and the adoption of anthracnose management strategies. These include the development of cultivars with resistance genes to the different pathotypes prevalent in the areas of cultivation, which will potentially reduce production costs.
Assessment and prediction of the nutritional index in septic patients: a propensity score-matched analysis
Authors: Liu Qiang , Zhang Jie 
Published: May 2023

Abstract
Background and Objectives: Traditional nutrition assessments to septic patients were effective but complex, TCBI was as a new score for assessing nutritional status and as the predictor for outcomes in patients with cardiovascular disease, its application was still relatively narrow. At present, there was no report on the application of this score in septic patients. We conducted this research to measure the effect of this score on short-term including 28-days mortality and 90-days mortality and long-term for 1-year outcomes in patients with sepsisMethods The median of TCBI was set as cut-off value to divide patients into two groups. Propensity score matching (PSM) was used to eliminate the bias caused by baseline characteristics between low-value group (TCBI < 1198) and high-value group (TCBI ≥ 1198). We estimated the trend of TCBI value and mortality by the restricted cubic spline, and examined the changes in survival time between different groups of TCBI via the Kaplan–Meier method. We use log-rank test to evaluate statistics significance. Hazard ratio was explored by cox regression model after PSM.Results In non-matched cohort, compared with patients in the low TCBI group, in high TCBI group, the patients were more younger, more heavier, higher incidence of chronic diseases, such as coronary artery disease, diabetes, hypertension, some parameters have statistical significance among age, body weight, suffering from diabetes, sapsii score. There was no significance in the length of stays between two different groups. Short-term and long-term mortality all were statistically significant. Between two groups, the 28-days mortality in high TCBI group was 13.67% vs 24.43%, at the 90-days endpoint time, the percentage was 19.82% vs 33.56%, and to the 1-year durations, the proportion of deaths was 29.61% vs 46.12%. Kaplan-Meier survival curve tested the trend of the survival probability as up to endpoint time. In non-matched cohort, the low TCBI s group (TCBI < 1198) was a greater risk of mortality, we examined two groups survival probability with time, the related log-rank test result was statistical with p < 0.001.Excluding baseline characteristics bias via propensity score matching, The low TCBI group still went with lower survival probability, and the same trend was consisted with the matched cohort (log-rank test p = 0.014).all potential risk factors after propensity score matching were included in multiple cox proportional hazards regression model, 28-days hazard ratio was more obvious among three outcomes with mortality risk, the hazard ratio was 1.668, and confidence interval was (1.132–2.457). In this model, the high TCBI group was always considered as the control group, all p-value showed statistical difference.Conclusions We tested TCBI in predicting the mortality for sepsis, the lower TCBI group was went with the higher mortality hazard in short-term and long-term. There was no statistical significance in different TCBI groups about length of stays in ICU.
Whole exome sequencing of adult Indians with apparently acquired Aplastic Anemia: initial experience at tertiary care hospital
Authors: Mehta Sudhir , Medicherla Krishna Mohan , Gulati Sandhya , Sharma Nidhi , Parveen Rabia , Mishra Ashwani Kumar , Gupta Sonal , Suravajhala Prashanth 
Published: May 2023

Abstract
Aplastic anaemia (AA) is a rare hypocellular bone marrow disease which can be acquired or constitutional. Nearly 10-30% patients with apparently acquired AA have mutations in telomerase reverse transcriptase gene (TERT) leading to bone marrow failure. The TERT plays a crucial role in regulating the telomerase ribonucleoprotein complex which otherwise causes short telomeres leading to AA. We used our benchmarked whole exome sequencing (WES) pipeline and systems bioinformatics approaches to identify sequence variants underlying AA in adult Indian subjects with apparently acquired AA. For 36 affected individuals, we sequenced coding regions to a mean coverage of 100× and a sufficient depth was achieved. The downstream validation and filtering was done to call the variants wherein we identified a host of candidate genes associated with AA who were treated with Cyclosporine A (CsA). Across all samples, six genes were shown to be associated with the AA phenotype with one non-coding SNP underlying intronic region as an exceptional case from interferon gamma (IFNG). While these variants (across the genes, viz. TERT (G/X), IFNG ( T/C), PIGA (T/X) or (T/A), NBS1/NBN(T/X), MPL (G/C) and CYP3A5) spanned across the subjects, a majority of control samples do not have these variants. We demonstrate the application of WES to discover the variants associated with CsA responders and non-responders in the Indian cohort.
The Role of Neutrophil Percentage-to-Albumin Ratio in Cardiovascular Disease Comorbidity and Psychological Distress
Authors: Lu Nan , Chi Yun Peng , Zhang Li Jun , Liu Mei Yan 
Published: May 2023

AbstractBackgroundInflammation is a comorbidity of cardiovascular disease (CVD) and psychological distress. The neutrophil percentage-to-albumin ratio (NPAR) has recently been reported as an inflammatory factor. We aimed to assess the role of NPAR in psychological distress associated with CVD comorbidity.MethodsData for the current study were obtained from a cross-sectional research project based in Beijing. All participants were aged ≥ 18 years and completed the questionnaire and hematological examination. Data on CVD, psychological distress, and NPAR were collected. Psychological distress was defined as symptoms of depression combined with anxiety. Univariate and multiple logistic regression analyses were used to assess the relationship between the NPAR and psychological distress.ResultsA total of 3695 participants (median age, 39 years; 55.67% male) were enrolled in the study. The incidence rates of CVD, psychological distress, and comorbidities of CVD and psychological distress were 16.86%, 6.90%, and 1.35%, respectively. NPAR was a significant risk factor for psychological distress after adjusting for other risk factors in all participants (odds ratio [OR] 4.043, 95% confidence interval [CI] 2.083–7.851;P < 0.001), patients with CVD (OR 7.284, 95% CI 1.428–37.161;P = 0.017), and non-CVD participants (OR 4.896, 95% CI 2.403–9.973;P < 0.001).ConclusionNPAR was associated with psychological distress in all participants, including patients with CVD and participants without CVD. The risk of psychological distress associated with NPAR was higher in participants with CVD than in those without CVD.
Exploring Impact of socio economic and Cultural factors for quality education (Case Study: Gedeo Zone)
Authors: Dukale Shimelis F. , Genalle Tesfaye G. , Meti Nigatu L. , Bali Firezer A. , Dukale Mesfin D. , Wote Tekalign T. , Hesso Elisabet G. 
Published: May 2023

Abstract
The brainstorming factor driving for education quality reduction is socio-economic and cultural related factors. In the course of the study, inferential and descriptive statistics was applied. Therefore, software package SPSS version22 are utilized.
Quantitative data obtained for survey the respondents rated "high" (x̄=3.50 to 4.20) with the statement “Coffee harvesting time & labour influencing students learning, youth recruitment on motor bicycle driving affecting their academic achievement, early marriage practices affecting students attendance & academic achievement, and Female home burden affecting their education and active participation” having x̄ = 3.53, 3.67, 3.75 and 3.67; SD=1.431, 1.442, 1.477 & 1.417.
However, the respondents rated “moderate" (x̄=2.7 to 3.4) on five statements “Parents education level influences on students’ academic achievement, Parents income level influences on their children’ academic achievement, Long distance of school from home affecting academic achievement, students have role model educated individuals for their further learning nearby community, and the home environment affecting students’ academic performances”. Its grand mean scores are X̄ =3.09, 3.30, 3.28, 3.12, & 2.93, SD= 1.411, 1.399, 1.428, 1.292 & 1.386 respectively.
In generally female student’s home burden and early marriage practices are among leading socio-cultural aspects that have been affecting student’s attendance & academic achievement in Gede’o Zone. Alongside to this, students labour participation during coffee harvesting time, and youth recruitment on motor bicycle driving greatly contributing for education wastage in which most students have been missing their class regularly and affecting their academic achievement latter on.
Mechanical properties and curing kinetics of biobased benzoxazine-epoxy copolymer for dental fiber post
Authors: Mora Phattarin , Rimdusit Sarawut , Karagiannidis Panagiotis , Srisorrach Ukrit , Jubsilp Chanchira 
Published: May 2023

Abstract
Biocopolymers based on vanillin/fufurylamine-biobenzoxazine (V-fa) and bioepoxy, epoxide castor oil (ECO), were prepared for fiber post application. The mechanical and thermal properties of the V-fa/ECO biocopolymers were assessed in regard to the influence of ECO contents. The addition of the ECO at amount of 20% by weight into the poly(V-fa) preserved the stiffness, the glass transition temperature and thermal stability nearly to the poly(V-fa). Dynamic differential scanning calorimetry (DSC) was used to examine the curing kinetics of the V-fa/ECO system with different heating rates. In order to determine the activation energy (Ea), the experimental data were subjected to the isoconversional approaches, namely Flynn-Wall-Ozawa and Friedman. The V-fa/ECO monomer mixture showed averaged Ea values of 105 kJ/mol and 94 kJ/mol, corresponding to typical Ea of petroleum-based benzoxazine/epoxy. The results derived using the curing reaction model and the experimental data were in good agreement, demonstrating the efficacy of the Flynn-Wall-Ozawa approach for determining the curing kinetics. The simulated mechanical response to external applied loads by finite element analysis of the tooth model restored with glass fiber-reinforced V-fa/ECO biocopolymer post showed a similar stress field with that restored with the commercial glass fiber post. Therefore, the biobased benzoxazine/epoxy copolymer overcomes many of the traditional shortcomings associated with petroleum-based epoxy resins used for dental fiber post, while demonstrating excellent mechanical and thermal properties.
Serum ApoB/ApoA1 ratio in patients with chronic hepatitis B and the occurrence of HBV related cirrhosis and HBV related hepatocellular carcinoma
Authors: Peng Shi , Cai Xin , Wang Li , Zhang Pingan 
Published: May 2023

Abstract
Background Clinical studies have found that chronic HBV infection affects the occurrence of cardiovascular disease by regulating cholesterol metabolism in liver cells. High serum apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio participates in the above regulation and is a risk factor for cardiovascular disease. However, it is unclear whether the ApoB/ApoA1 ratio is associated with chronic HBV infection and its disease progression.Method According to the inclusion and exclusion criteria, all 328 participants treated at Renmin Hospital of Wuhan University from March 2021 to March 2022, were divided into HCC group (107 cases), LC group (64 cases), CHB group (62 cases), Chronic hepatitis C (CHC) group (46 cases) and Hepatitis E Virus (HEV) group (49 cases). Serum ApoA1 and ApoB concentrations were measured at admission, and the ApoB/ApoA1 ratio was calculated. We compared the levels of laboratory parameters in each group and further analyzed ApoB/ApoA1 levels in HCC patients and LC patients with different severity. ROC curves were plotted to analyze the early diagnostic ability of ApoB/ApoA1 ratio for HBV-related HCC. Logistic regression and restricted cubic spline analysis were used to investigate the association between ApoB/ApoA1 ratio and LC and HCC risk.Result Comparison of ApoB/ApoA1 ratio between the groups: HEV group > CHB group > LC group > HCC group > CHC group, early-stage HCC > middle-stage HCC > advanced-stage HCC, Class A LC > Class B LC > Class C LC. Serum ApoB/ApoA1 ratio combined diagnosis with AFP could improve the detection efficacy and specificity of AFP for HCC.The incidence of LC and HCC in each logistic regression model was negatively correlated with the serum ApoB/ApoA1 ratio in CHB patients (P < 0.05). After adjusting for all confounding factors included in this study, restricted cubic spline analysis found that within a certain range, serum ApoB/ApoA1 ratio was inversely associated with the prevalence of LC or HCC in CHB patients.Conclusion Serum ApoB/ApoA1 ratio in CHB patients may help identify high-risk patients for HCC or LC, thereby preventing the development of HCC or LC, or early diagnosis of HCC.
Thermal Characterization of Electronic Power Component: a comparison between resistive and fiber Bragg grating sensors
Authors: Basma Bechir Mahamat , Pietroy David , Boukhari Mahamat Issa , Chahbi Zacharia , Blanchet Thomas , Chatelon Jean Pierre , Capraro Stéphane , Rousseau Jean-Jacques 
Published: May 2023

Abstract
The operating temperature can be critical in some electronic circuits to ensure the integrity and proper functioning of a circuit, especially in power electronics. A temperature mapping can then be useful to anticipate the malfunction. The objective of this paper is to set up methods to study the thermal behavior of power electronic components such as inductors and transformers. Two methods are compared: a first one based on resistive integrated sensors and a second one based on fiber Bragg grating sensors. The analysis of each method is divided into two parts: the calibration of the sensor and the validation of the procedure.
Sepsis-associated acute kidney injury in the intensive care unit: Incidence, Patient Characteristics, Timing, Trajectory, Treatment, and Associated Outcomes. A multicenter, observational study.
Authors: White Kyle , Serpa-Neto Ary , Hurford Rod , Clement Pierre , Laupland Kevin , See Emily , Mccullough James , White Hayden , Shekar Kiran , Tabah Alexis , Ramanan Mahesh , Garrett Peter , Attokaran Antony , Luke Stephen , Senthuran Siva , Mcilroy Phillipa , Bellomo Rinaldo 
Published: May 2023

Abstract
Purpose The Acute Disease Quality Initiative (ADQI) Workgroup recently released a consensus definition of sepsis-associated acute kidney injury (SA-AKI), combining Sepsis-3 and Kidney Disease Improving Global Outcomes (KDIGO) AKI criteria. This study aims to described the epidemiology of SA-AKI. Methods Retrospective cohort study in 12 intensive care units (ICU) from 2015 to 2021. We studied the incidence, patient characteristics, timing, trajectory, treatment, and associated outcomes of the ADQI SA-AKI definition. Results Of 84,831 admissions, 15,549 met the SA-AKI criteria with its incidence peaking at > 20% in 2021. SA-AKI patients were typically admitted from home via the emergency department (ED) with median time to SA-AKI diagnosis of one day (IQR 1–1) from ICU admission. At diagnosis, most SA-AKI patients had a stage 1 (55%) AKI, mostly due to the low urinary output (UO) criterion only (67%). Compared to diagnosis by creatinine alone, or both UO and creatinine criteria, patients diagnosed by UO alone had lower RRT requirement (3.3% vs 19% vs 51%; p < 0.001), which was consistent across all stages of AKI. SA-AKI hospital mortality was 19% and SA-AKI was independently associated with increased mortality. However, diagnosis by low UO only carried an odds ratio of 0.37 (95% CI, 0.34–0.39) for mortality. Conclusion SA-AKI occurs in one in five ICU patients, is diagnosed on day one, and carries significant morbidity and mortality risk with patients mostly admitted from home via the ED. However, most SA-AKI is stage 1 and mostly due to low UO, which carries much lower risk than diagnosis by other criteria.