bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Atmospheric Cooling on the High‐Frequency Submesoscale Vertical Heat Flux
Authors: Aparco‐Lara Jonathan , Torres Hector S. , Gomez‐Valdes Jose 
Published: August 2023

AbstractRecent simulations suggest that submesoscale motions with scales smaller than 30 km and frequencies greater than 1 day−1 drive upward vertical heat transport. These simulations have prompted us to revisit the mechanisms that explain high‐frequency (HF) vertical heat fluxes (VHFs) within the surface mixed layer (ML). Here, an idealized numerical simulation of a re‐entrant channel flow with an unbalanced submesoscale thermal front is used to analyze the impact of surface cooling on HF VHFs. Two types of simulations are analyzed: forced and unforced. The VHFs cospectrum analysis shows that surface diurnal cooling increases VHFs, reaching frequencies larger than 1 day−1. However, the fastest‐growing length scale of ML instabilities limits the extension of positive VHFs toward fine scales. Symmetric and gravitational instabilities are the main conduits producing ageostrophic HF and small‐scale structures, which in turn enhance upward VHFs across the diurnal frequency. A comparison between forced‐idealized simulations with the K‐profile parameterization scheme and a realistic regional simulation in the frequency‐wavenumber space, reveals that the two simulation types reproduce similar VHFs near the diurnal frequency. However, the realistic simulation displays higher VHFs than the forced‐idealized simulation. This study emphasizes that surface diurnal cooling significantly impacts HF VHFs. However, this impact is not sufficient to reach the HF VHFs estimated in realistic submesoscale‐permitting and tidal‐resolving simulations.
Surface Energy Dynamics and Canopy Structural Properties in Intact and Disturbed Forests in the Southern Amazon
Authors: Rangel Pinagé Ekena , Bell David M. , Longo Marcos , Silva Carlos A. , Csillik Ovidiu , Huete Alfredo 
Published: August 2023

AbstractThe Brazilian Amazon has been a focus of land development with large swaths of forests converted to agriculture. Forest degradation by selective logging and fires has accompanied the agricultural frontier and has resulted in significant impacts on Amazonian ecosystems. Changes in forest structure resulting from forest disturbances have large impacts on the surface energy balance, including on land surface temperature (LST) and evapotranspiration (ET). This study's objective is to assess the effects of forest disturbances on water fluxes and forest structure in a transitional forest site in the Southern Amazon. We used ET and LST products from MODIS and Landsat 8 and GEDI‐derived forest structure data to address our research questions. We found that disturbances induced seasonal water stress, more pronounced in croplands/pastures than in forests (differences up to 20% in the dry season), and more pronounced in second‐growth and recently burned areas than in logged and intact forests (differences up to 12% in the dry season). Moreover, ET and LST were negatively related, with more consistent relationships across disturbance classes in the dry season (R2: 0.41–0.87) than in the wet season (R2: 0.18–0.49). Forest and cropland or pasture classes showed contrasting relationships in the dry season. Finally, we found that forest structure exhibited stronger relationships with ET and LST in the most disturbed forests (R2: 0.01–0.43) than in the least disturbed forests (R2 < 0.05). Our findings help to elucidate degraded forests functioning under a changing climate and to improve estimates of water and energy fluxes in Amazonian degraded forests.
Salt Tectonics Versus Shortening: Recognizing Pre‐Orogenic Evaporite Deformation in Salt‐Bearing Fold‐And‐Thrust Belts on the Example of the Silica Nappe (Inner Western Carpathians)
Authors: Oravecz Éva , Héja Gábor , Fodor László 
Published: August 2023

AbstractRecognizing salt‐related structures and differentiating them from tectonic shortening‐related anticlines and synclines can be a very challenging task in salt‐bearing fold‐and‐thrust belts, especially in poor outcrop conditions. In this study, we explain several diagnostic structural and sedimentary features that may be used to distinguish pre‐orogenic halokinetic structures from shortening‐related structures on the example of the Silica Nappe (Inner Western Carpathians, Central Europe). Detailed structural mapping in this area resulted in the recognition of several pre‐orogenic salt‐related structures, including linear salt walls and minibasins. Initial evaporite movement started as early as the late Early Triassic, and widespread diapirism occurred during the Middle to Late Triassic, ultimately leading to facies differentiation, with carbonate platform growth in the subsiding minibasins and reduced basinal deposition on top of the diapirs. Later, the inherited salt structures localized the deformation during the Cretaceous Alpine orogeny, and exerted a strong control on the geometry and kinematics of the subsequent deformations. Our new interpretation explains previously unsolved structural problems in the Silica Nappe, like pre‐orogenic thickness variations during the post‐rift phase, frequent young‐on‐older type thrust contacts and multiple folding directions with variable vergencies. The results point out that the Silica Nappe is a fold‐and‐thrust belt, where pre‐orogenic salt tectonics and its effects on the fold‐and‐thrust belt evolution can be studied in detail.
The Joining of North and South China During the Permian: Coherent Metamorphic Evidence From East Asia Orogenesis
Authors: Zhao L. , Tang H. , Mitchell R. N. , Li Q. L. , Zhou X. W. , Zhai M. G. 
Published: August 2023

AbstractThe joining of the North and South China blocks marks the formation of the united East Asian continent, which is an integral part of Pangea. The amalgamation of these two continental blocks also resulted in the formation of the world‐class ultrahigh pressure orogenic belt, namely the Dabie–Sulu orogenic belt. Figuring out the time of the initial collision between the two continents is critical for resolving questions such as the duration and the geodynamic processes of the orogeny. A Triassic joining time has been suggested by the geochronology of the eclogite facies rocks in this orogenic belt. However, paleomagnetic and paleontological studies suggested a Permian docking time for these continental blocks. In this paper, we present new metamorphic ages of rocks from northern Dabie and the Permo–Triassic intracontinental orogen of South China, which are all closely associated with this continental collisional event. New age dating results, as well as a synthesis of recent studies on metamorphic rocks occurring in southeastern North China and the Cathaysia Block of South China, show that the onset of the collisional orogenesis along the eastern part of the orogenic belt dates back to the Middle Permian (270–252 Ma). Considering these data and other geological records, we provide a new tectonic model for the major continents of East Asia, in which we show that the initial collision between North and South China occurred in the east during the Middle Permian, and then propagated westward. Continental collisions forming mountains and closing seaways in East Asia thus apparently occurred before the end‐Permian mass extinction, suggesting these paleogeographic changes might have also preconditioned and facilitated the end‐Permian biospheric crisis in the region.
Redefining precision radiotherapy through liquid biopsy
Authors: McLaren D. B. , Aitman T. J. 
Published: August 2023

AbstractPrecision radiotherapy refers to the ability to deliver radiation doses with sub-millimetre accuracy. It does not however consider individual variation in tumour or normal tissue response, failing to maximise tumour control and minimise toxicity. Combining precise delivery with personalised dosing, through analysis of cell-free DNA, would redefine precision in radiotherapy.
Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1
Authors: Bu Huitong , Lan Xianling , Cheng Haojie , Pei Chaozhu , Ouyang Min , Chen Yan , Huang Xiaoqin , Yu Li , Tan Yongjun 
Published: August 2023

AbstractDisrupting protein–protein interactions (PPIs) has emerged as a promising strategy for cancer drug development. Interfering peptides disrupting PPIs can be rationally designed based on the structures of natural sequences mediating these interactions. Transcription factor FOXM1 overexpresses in multiple cancers and is considered an effective target for cancer therapeutic drug development. Using a rational design approach, we have generated a peptide library from the FOXM1 C-terminal sequence and screened FOXM1-binding peptides. Combining FOXM1 binding and cell inhibitory results, we have obtained a FOXM1-targeting interfering peptide M1-20 that is optimized from the natural parent peptide to the D-retro-inverso peptide. With improved stability characteristics, M1-20 inhibits proliferation and migration, and induces apoptosis of cancer cells. Mechanistically, M1-20 inhibits FOXM1 transcriptional activities by disrupting its interaction between the MuvB complex and the transcriptional co-activator CBP. These are consistent with the results that M1-20 suppresses cancer progression and metastasis without noticeable toxic and side effects in wild-type mice. These findings reveal that M1-20 has the potential to be developed as an anti-cancer drug candidate targeting FOXM1.
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Authors: Verboom Lien , Anderson Christopher J. , Jans Maude , Petta Ioanna , Blancke Gillian , Martens Arne , Sze Mozes , Hochepied Tino , Ravichandran Kodi S. , Vereecke Lars , van Loo Geert 
Published: August 2023

AbstractThe intestinal epithelium is a single cell layer that is constantly renewed and acts as a physical barrier that separates intestinal microbiota from underlying tissues. In inflammatory bowel disease (IBD) in humans, as well as in experimental mouse models of IBD, this barrier is impaired, causing microbial infiltration and inflammation. Deficiency in OTU deubiquitinase with linear linkage specificity (OTULIN) causes OTULIN-related autoinflammatory syndrome (ORAS), a severe inflammatory pathology affecting multiple organs including the intestine. We show that mice with intestinal epithelial cell (IEC)-specific OTULIN deficiency exhibit increased susceptibility to experimental colitis and are highly sensitive to TNF toxicity, due to excessive apoptosis of OTULIN deficient IECs. OTULIN deficiency also increases intestinal pathology in mice genetically engineered to secrete excess TNF, confirming that chronic exposure to TNF promotes epithelial cell death and inflammation in OTULIN deficient mice. Mechanistically we demonstrate that upon TNF stimulation, OTULIN deficiency impairs TNF receptor complex I formation and LUBAC recruitment, and promotes the formation of the cytosolic complex II inducing epithelial cell death. Finally, we show that OTULIN deficiency in IECs increases susceptibility to Salmonella infection, further confirming the importance of OTULIN for intestinal barrier integrity. Together, these results identify OTULIN as a major anti-apoptotic protein in the intestinal epithelium and provide mechanistic insights into how OTULIN deficiency drives gastrointestinal inflammation in ORAS patients.
HSF-1/miR-145-5p transcriptional axis enhances hyperthermic intraperitoneal chemotherapy efficacy on peritoneal ovarian carcinosis
Authors: Di Agostino Silvia , Canu Valeria , Donzelli Sara , Pulito Claudio , Sacconi Andrea , Ganci Federica , Valenti Fabio , Goeman Frauke , Scalera Stefano , Rollo Francesca , Bagnato Anna , Diodoro Maria Grazia , Vizza Enrico , Carosi Mariantonia , Rufini Beatrice , Federici Orietta , Giofrè Manuel , Carboni Fabio , Muti Paola , Ciliberto Gennaro , Strano Sabrina , Valle Mario , Blandino Giovanni 
Published: August 2023

AbstractHyperthermic intraperitoneal administration of chemotherapy (HIPEC) increases local drug concentrations and reduces systemic side effects associated with prolonged adjuvant intraperitoneal exposure in patients affected by either peritoneal malignancies or metastatic diseases originating from gastric, colon, kidney, and ovarian primary tumors. Mechanistically, the anticancer effects of HIPEC have been poorly explored. Herein we documented that HIPEC treatment promoted miR-145-5p expression paired with a significant downregulation of its oncogenic target genes c-MYC, EGFR, OCT4, and MUC1 in a pilot cohort of patients with ovarian peritoneal metastatic lesions. RNA sequencing analyses of ovarian peritoneal metastatic nodules from HIPEC treated patients unveils HSF-1 as a transcriptional regulator factor of miR-145-5p expression. Notably, either depletion of HSF-1 expression or chemical inhibition of its transcriptional activity impaired miR-145-5p tumor suppressor activity and the response to cisplatin in ovarian cancer cell lines incubated at 42 °C. In aggregate, our findings highlight a novel transcriptional network involving HSF-1, miR145-5p, MYC, EGFR, MUC1, and OCT4 whose proper activity contributes to HIPEC anticancer efficacy in the treatment of ovarian metastatic peritoneal lesions.
An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer
Authors: Zhang Xiaozhe , Shan Gao , Li Na , Chen Jingyi , Ji Changyang , Li Xiaoxiao , Jiang Liwen , Lee Terence Kin Wah , Keng Vincent W. , Zhao Yanxiang 
Published: August 2023

AbstractAutophagy is a lysosome-dependent bulk degradation process essential for cell viability but excessive autophagy leads to a unique form of cell death termed autosis. Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with notable defect in its autophagy process. In previous studies, we developed stapled peptides that specifically targeted the essential autophagy protein Beclin 1 to induce autophagy and promote endolysosomal trafficking. Here we show that one lead peptide Tat-SP4 induced mild increase of autophagy in TNBC cells but showed potent anti-proliferative effect that could not be rescued by inhibitors of programmed cell death pathways. The cell death induced by Tat-SP4 showed typical features of autosis including sustained adherence to the substrate surface, rupture of plasma membrane and effective rescue by digoxin, a cardioglycoside that blocks the Na+/K+ ATPase. Tat-SP4 also induced prominent mitochondria dysfunction including loss of mitochondria membrane potential, elevated mitochondria reactive oxygen species and reduced oxidative phosphorylation. The anti-proliferative effect of Tat-SP4 was confirmed in a TNBC xenograft model. Our study uncovers three notable aspects of autosis. Firstly, autosis can be triggered by moderate increase in autophagy if such increase exceeds the endogenous capacity of the host cells. Secondly, mitochondria may play an essential role in autosis with dysregulated autophagy leading to mitochondria dysfunction to trigger autosis. Lastly, intrinsic autophagy deficiency and quiescent mitochondria bioenergetic profile likely render TNBC cells particularly susceptible to autosis. Our designed peptides like Tat-SP4 may serve as potential therapeutic candidates against TNBC by targeting this vulnerability.
Regio- and enantioselective CuH-catalyzed 1,2- and 1,4-hydrosilylation of 1,3-enynes
Authors: Wang Zi-Lu , Li Qi , Yang Meng-Wei , Song Zhao-Xin , Xiao Zhen-Yu , Ma Wei-Wei , Zhao Jin-Bo , Xu Yun-He 
Published: August 2023

AbstractWe report a copper-catalyzed ligand-controlled selective 1,2- and 1,4-hydrosilylation of 1,3-enynes, which furnishes enantiomerically enriched propargyl- and 1,2-allenylsilane products in high yields with excellent enantioselectivities (up to 99% ee). This reaction proceeds under mild conditions, shows broad substrate scope for both 1,3-enynes and trihydrosilanes, and displays excellent regioselectivities. Mechanistic studies based on deuterium-labeling reactions and density functional theory (DFT) calculations suggest that allenylcopper is the dominant reactive intermediate under both 1,2- and 1,4-hydrosilylation conditions, and it undergoes metathesis with silanes via selective four-membered or six-membered transition state, depending on the nature of the ligand. The weak interactions between the ligands and the reacting partners are found to be the key controlling factor for the observed regioselectivity switch. The origin of high enantiocontrol in the 1,4-hydrosilylation is also revealed by high level DLPNO-CCSD(T) calculations.
Exciton Superposition across Moiré States in a Semiconducting Moiré Superlattice
Authors: Lian Zhen , Chen Dongxue , Meng Yuze , Chen Xiaotong , Su Ying , Banerjee Rounak , Taniguchi Takashi , Watanabe Kenji , Tongay Sefaattin , Zhang Chuanwei , Cui Yong-Tao , Shi Su-Fei 
Published: August 2023

AbstractMoiré superlattices of semiconducting transition metal dichalcogenides enable unprecedented spatial control of electron wavefunctions, leading to emerging quantum states. The breaking of translational symmetry further introduces a new degree of freedom: high symmetry moiré sites of energy minima behaving as spatially separated quantum dots. We demonstrate the superposition between two moiré sites by constructing a trilayer WSe2/monolayer WS2 moiré heterojunction. The two moiré sites in the first layer WSe2 interfacing WS2 allow the formation of two different interlayer excitons, with the hole residing in either moiré site of the first layer WSe2 and the electron in the third layer WSe2. An electric field can drive the hybridization of either of the interlayer excitons with the intralayer excitons in the third WSe2 layer, realizing the continuous tuning of interlayer exciton hopping between two moiré sites and a superposition of the two interlayer excitons, distinctively different from the natural trilayer WSe2.
Experimental impacts of grazing on grassland biodiversity and function are explained by aridity
Authors: Zhang Minna , Delgado-Baquerizo Manuel , Li Guangyin , Isbell Forest , Wang Yue , Hautier Yann , Wang Yao , Xiao Yingli , Cai Jinting , Pan Xiaobin , Wang Ling 
Published: August 2023

AbstractGrazing by domestic herbivores is the most widespread land use on the planet, and also a major global change driver in grasslands. Yet, experimental evidence on the long-term impacts of livestock grazing on biodiversity and function is largely lacking. Here, we report results from a network of 10 experimental sites from paired grazed and ungrazed grasslands across an aridity gradient, including some of the largest remaining native grasslands on the planet. We show that aridity partly explains the responses of biodiversity and multifunctionality to long-term livestock grazing. Grazing greatly reduced biodiversity and multifunctionality in steppes with higher aridity, while had no effects in steppes with relatively lower aridity. Moreover, we found that long-term grazing further changed the capacity of above- and below-ground biodiversity to explain multifunctionality. Thus, while plant diversity was positively correlated with multifunctionality across grasslands with excluded livestock, soil biodiversity was positively correlated with multifunctionality across grazed grasslands. Together, our cross-site experiment reveals that the impacts of long-term grazing on biodiversity and function depend on aridity levels, with the more arid sites experiencing more negative impacts on biodiversity and ecosystem multifunctionality. We also highlight the fundamental importance of conserving soil biodiversity for protecting multifunctionality in widespread grazed grasslands.
Observation of ultrafast interfacial Meitner-Auger energy transfer in a Van der Waals heterostructure
Authors: Dong Shuo , Beaulieu Samuel , Selig Malte , Rosenzweig Philipp , Christiansen Dominik , Pincelli Tommaso , Dendzik Maciej , Ziegler Jonas D. , Maklar Julian , Xian R. Patrick , Neef Alexander , Mohammed Avaise , Schulz Armin , Stadler Mona , Jetter Michael , Michler Peter , Taniguchi Takashi , Watanabe Kenji , Takagi Hidenori , Starke Ulrich , Chernikov Alexey , Wolf Martin , Nakamura Hiro , Knorr Andreas , Rettig Laurenz , Ernstorfer Ralph 
Published: August 2023

AbstractAtomically thin layered van der Waals heterostructures feature exotic and emergent optoelectronic properties. With growing interest in these novel quantum materials, the microscopic understanding of fundamental interfacial coupling mechanisms is of capital importance. Here, using multidimensional photoemission spectroscopy, we provide a layer- and momentum-resolved view on ultrafast interlayer electron and energy transfer in a monolayer-WSe2/graphene heterostructure. Depending on the nature of the optically prepared state, we find the different dominating transfer mechanisms: while electron injection from graphene to WSe2 is observed after photoexcitation of quasi-free hot carriers in the graphene layer, we establish an interfacial Meitner-Auger energy transfer process following the excitation of excitons in WSe2. By analysing the time-energy-momentum distributions of excited-state carriers with a rate-equation model, we distinguish these two types of interfacial dynamics and identify the ultrafast conversion of excitons in WSe2 to valence band transitions in graphene. Microscopic calculations find interfacial dipole-monopole coupling underlying the Meitner-Auger energy transfer to dominate over conventional Förster- and Dexter-type interactions, in agreement with the experimental observations. The energy transfer mechanism revealed here might enable new hot-carrier-based device concepts with van der Waals heterostructures.
Proton-controlled molecular ionic ferroelectrics
Authors: Huang Yulong , Gottfried Jennifer L. , Sarkar Arpita , Zhang Gengyi , Lin Haiqing , Ren Shenqiang 
Published: August 2023

AbstractMolecular ferroelectric materials consist of organic and inorganic ions held together by hydrogen bonds, electrostatic forces, and van der Waals interactions. However, ionically tailored multifunctionality in molecular ferroelectrics has been a missing component despite of their peculiar stimuli-responsive structure and building blocks. Here we report molecular ionic ferroelectrics exhibiting the coexistence of room-temperature ionic conductivity (6.1 × 10−5 S/cm) and ferroelectricity, which triggers the ionic-coupled ferroelectric properties. Such ionic ferroelectrics with the absorbed water molecules further present the controlled tunability in polarization from 0.68 to 1.39 μC/cm2, thermal conductivity by 13% and electrical resistivity by 86% due to the proton transfer in an ionic lattice under external stimuli. These findings enlighten the development of molecular ionic ferroelectrics towards multifunctionality.