bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prioritization of pig farm biosecurity for control of Salmonella and hepatitis E virus infections: results of a European expert opinion elicitation
Authors: Galipó Erika , Zoche-Golob Veit , Sassu Elena Lucia , Prigge Christopher , Sjölund Marie , Tobias Tijs , Rzeżutka Artur , Smith Richard Piers , Burow Elke 
Published: March 2023

AbstractBackgroundIn the literature, there is absent or weak evidence on the effectiveness of biosecurity measures to the control ofSalmonellaspp. and hepatitis E virus (HEV) on pig farms. Therefore, the present study aimed to collect, weigh, and compare opinions from experts on the relevance of several biosecurity measures. An online questionnaire was submitted to selected experts, from multiple European countries, knowledgeable on either HEV orSalmonellaspp.,in either indoor or outdoor pig farming systems (settings). The experts ranked the relevance of eight biosecurity categories with regards to effectiveness in reducing the two pathogens separately, by assigning a score from a total of 80, and within each biosecurity category they scored the relevance of specific biosecurity measures (scale 1–5). Agreement among experts was analysed across pathogens and acrosssettings.ResultsAfter filtering for completeness and expertise, 46 responses were analysed, with 52% of the experts identified as researchers/scientists, whereas the remaining 48% consisted of non-researchers, veterinary practitioners and advisors, governmental staff, and consultant/industrial experts. The experts self-declared their level of knowledge but neither Multidimensional Scaling nor k-means cluster analyses produced evidence of an association between expertise and the biosecurity answers, and so all experts’ responses were analysed together without weighting or adaptation. Overall, the top-ranked biosecurity categories werepig mixing;cleaning and disinfection;feed, water and bedding; andpurchase of pigs or semen, while the lowest ranked categories weretransport,equipment,animals(other than pigs and including wildlife) andhumans.Cleaning and disinfectionwas ranked highest for both pathogens in the indoor setting, whereaspig mixingwas highest for outdoorsettings. Several (94/222, 42.3%) measures across all foursettingswere considered highly relevant. Measures with high disagreement between the respondents were uncommon (21/222, 9.6%), but more frequent for HEV compared toSalmonellaspp.ConclusionsThe implementation of measures from multiple biosecurity categories was considered important to controlSalmonellaspp. and HEV on farms, and pig mixing activities, as well as cleaning and disinfection practices, were perceived as consistently more important than others. Similarities and differences in the prioritised biosecurity measures were identified between indoor and outdoor systems and pathogens. The study identified the need for further research especially for control of HEV and for biosecurity in outdoor farming.
Spatial distribution and determinants of high-risk fertility behavior among reproductive-age women in Ethiopia
Authors: Aragaw Fantu Mamo , Chilot Dagmawi , Belay Daniel Gashaneh , Merid Mehari Woldemariam , Kibret Anteneh Ayelign , Alem Adugnaw Zeleke , Asratie Melaku Hunie 
Published: March 2023

Abstract
Background
In low-and-middle-income, including Ethiopia, high-risk fertility behavior is a major public health concern. High-risk fertility behavior has an adverse influence on maternal and child health, which hampered efforts to reduce maternal and child morbidity and mortality in Ethiopia. Therefore, this study aimed to assess the spatial distribution and associated factors of high-risk fertility behavior among reproductive-age women in Ethiopia using recent nationally representative data.

Methods
Secondary data analysis was done with a total weighted sample of 5865 reproductive-aged women using the latest mini EDHS 2019. The spatial distribution of high-risk fertility behavior in Ethiopia was determined using spatial analysis. Multilevel multivariable regression analysis was used to identify predictors of high-risk fertility behavior in Ethiopia.

Results
The prevalence of high-risk fertility behavior among reproductive-age women in Ethiopia was 73.50% (95% CI 72.36%, 74.62%). Women with primary education [AOR = 0.44; 95%CI; 0.37, 0.52], women with secondary and above education [AOR = 0.26; 95%CI; 0.20, 0.34], being Protestant religion followers [AOR = 1.47; 95%CI; 1.15, 1.89], being Muslim religion follower [AOR = 1.56; 95%CI; 1.20, 2.01], having television [AOR = 2.06; 95%CI; 1.54, 2.76], having ANC visit [AOR = 0.78; 95%CI; 0.61, 0.99], using contraception [AOR = 0.77; 95%CI; 0.65, 0.90], living in rural areas [AOR = 1.75; 95%CI; 1.22, 2.50] were significantly associated with high-risk fertility behavior. Significant hotspots of high-risk fertility behavior were detected in Somalia, SNNPR, Tigray region, and Afar regions of Ethiopia.

Conclusions
A significant proportion of women in Ethiopia engaged in high-risk fertility behavior. High-risk fertility behavior was distributed non-randomly across Ethiopian regions. Policymakers and stakeholders should design interventions that take into account the factors that predispose women to have high-risk fertility behaviors and women who reside in areas with a high proportion of high-risk fertility behaviors to reduce the consequences of high-risk fertility behaviors.
Prognostic analysis of curatively resected pancreatic cancer using harmonized positron emission tomography radiomic features
Authors: Watanabe Masao , Ashida Ryo , Miyakoshi Chisato , Arizono Shigeki , Suga Tsuyoshi , Kanao Shotaro , Kitamura Koji , Ogawa Takahisa , Ishikura Reiichi 
Published: March 2023

Abstract
Background
Texture features reflecting tumour heterogeneity enable us to investigate prognostic factors. The R package ComBat can harmonize the quantitative texture features among several positron emission tomography (PET) scanners. We aimed to identify prognostic factors among harmonized PET radiomic features and clinical information from pancreatic cancer patients who underwent curative surgery.

Methods
Fifty-eight patients underwent preoperative enhanced dynamic computed tomography (CT) scanning and fluorodeoxyglucose PET/CT using four PET scanners. Using LIFEx software, we measured PET radiomic parameters including texture features with higher order and harmonized these PET parameters. For progression-free survival (PFS) and overall survival (OS), we evaluated clinical information, including age, TNM stage, and neural invasion, and the harmonized PET radiomic features based on univariate Cox proportional hazard regression. Next, we analysed the prognostic indices by multivariate Cox proportional hazard regression (1) by using either significant (p < 0.05) or borderline significant (p = 0.05–0.10) indices in the univariate analysis (first multivariate analysis) or (2) by using the selected features with random forest algorithms (second multivariate analysis). Finally, we checked these multivariate results by log-rank test.

Results
Regarding the first multivariate analysis for PFS after univariate analysis, age was the significant prognostic factor (p = 0.020), and MTV and GLCM contrast were borderline significant (p = 0.051 and 0.075, respectively). Regarding the first multivariate analysis of OS, neural invasion, Shape sphericity and GLZLM LZLGE were significant (p = 0.019, 0.042 and 0.0076). In the second multivariate analysis, only MTV was significant (p = 0.046) for PFS, whereas GLZLM LZLGE was significant (p = 0.047), and Shape sphericity was borderline significant (p = 0.088) for OS. In the log-rank test, age, MTV and GLCM contrast were borderline significant for PFS (p = 0.08, 0.06 and 0.07, respectively), whereas neural invasion and Shape sphericity were significant (p = 0.03 and 0.04, respectively), and GLZLM LZLGE was borderline significant for OS (p = 0.08).

Conclusions
Other than the clinical factors, MTV and GLCM contrast for PFS and Shape sphericity and GLZLM LZLGE for OS may be prognostic PET parameters. A prospective multicentre study with a larger sample size may be warranted.
Repair of spina bifida cystica: an institutional experience
Authors: Khalil Amr Farid , Badr Hatem Ibraheem , Zaher Ahmed , Elshirbiny Mohammad Fekry , Elnaggar Ahmed Mahmoud , Badran Mohamed , Zayed Ahmed Elsaaid , Abdelhalim Mostafa Mohammed , Amen Mohamed Mohsen 
Published: March 2023

Abstract
Objective
Although most cases with spina bifida cystica could be closed by primary skin closure with or without undermining its edges, about 25% of patients have large defects not amenable for closure by these simple methods. We conducted this study to review our techniques in closing spina bifida cystica defects.

Methods
We retrospectively reviewed the data of consecutive 21 patients diagnosed with spina bifida cystica in our setting. According to the surface area of the defect, the approach was decided; primary closure for small defects (11 cases) and flap-based approach for large defects (10 patients).

Results
The age of the included pediatric patients ranged between 3 and 75 days. For the primary closure cases, a vertical incision was done in seven cases. For the flap-based group, bilateral rotation transposition flap was done for circular defects (7 cases) while elliptical ones were repaired via bilateral V–Y flap. Complete skin healing was achieved after two weeks (range 12–18 days) in most cases. Complications were as follows; for the primary closure group, cerebrospinal fluid leakage (18.18%%), partial wound dehiscence (18.18%) and superficial surgical site infection (9.09%). In the flap-based group, CSF leakage (20%), superficial surgical site infection (10%), and distal flap necrosis (30%) were detected. Reoperation for wound complication was needed only in one case in the flap-based group.

Conclusions
Flap-based procedures are recommended for patients with large spina bifida cystica defects because of less tissue dissection and low complication rates. Primary closure should be kept for small defects.
A new receiver clock model to enhance BDS-3 real-time PPP time transfer with the PPP-B2b service
Authors: Ge Yulong , Wang Qing , Wang Yong , Lyu Daqian , Cao Xinyun , Shen Fei , Meng Xiaolin 
Published: March 2023

AbstractA new Precise Point Positioning (PPP) service, called the PPP-B2b service, has been implemented in the BeiDou-3 Navigation Satellite System (BDS-3), which brings new opportunities for time transfer. However, the solution using the traditional PPP method with the PPP-B2b correction still absorbs some unknown errors and needs reconverging when there exist abnormal data. We developed a new receiver clock model to improve PPP time transfer using the PPP-B2b correction. The traditional PPP time transfers using PPP-B2b with BDS-3, Global Positioning System (GPS), and BDS-3/GPS (Scheme1) are compared with the corresponding time transfer with the proposed clock model (Scheme2). The results show that GPS-only PPP is not recommended because of low accuracy of 2 ns. BDS-3 or BDS-3/GPS PPP time transfers in Scheme1 can realize about 0.2 ns accuracy. When the new clock model is applied, the accuracy can be improved by up to 45% and 39.8% for BDS-3 and BDS-3/GPS PPP, respectively. The proposed clock model can significantly improve the short-term frequency stability by 57.4%, but less for the long-term stability.
Quality of life among Iranian major depressive disorder patients: a qualitative study
Authors: Rezaiye Milad , Radfar Moloud , MaslakPak Masumeh Hemmati 
Published: March 2023

Abstract
Background
Research indicates that the prevalence of Major Depressive Disorder (MDD) is high and it reduces patient’s Quality of Life (QoL). Nowadays, in addition to reducing the symptoms of MDD, emphasis is on the concept of QoL as the purpose of treating these patients. However, we still do not know what these patient’s attitudes and perceptions are about QoL. This study aims to clarify the Iranian patient’s attitudes and perceptions of QoL’s meaning through a qualitative paradigm.

Results
During the data analysis, “Agitation factors”, “Destructive effects”, and “Gratifications” were developed as three main themes with 13 main categories, 39 sub-categories, and 879 codes. According to the findings the main priority of patients with MDD was Agitation factors, which plays a remarkable role in the concept of QoL.

Conclusions
MDD leads to deterioration in the QoL of these individuals in different parts. The novelty of this study leads to the creation of a deep and realistic attitude in national and global nurses towards the QoL of majorly depressed patients in order to remove the aggravating factors of the disorder and create a pleasant life based on the adequate and specialized understanding of the consequences of this disorder according to the preferences of patients and provide a suitable quality of life for these patients.
MRI of the pelvic floor in female patients with stress urinary incontinence, pre- and postoperative and/or physiotherapy: analysis of the defect-specific approach
Authors: Abdelrahman Sherif Fathy , Abdelatty Mohamed A. , Amer Basma , Kamel Sara Mahmoud , Hussein Ahmed Fathy , El Sayed Rania Farouk 
Published: March 2023

Abstract
Background
Stress urinary incontinence (SUI) is a common disabling pelvic floor dysfunction, particularly among aging women. Magnetic resonance imaging (MRI) with dynamic sequences has been proven reliable for detecting pelvic floor weaknesses, especially with multiple compartments defects. Since surgical and non-surgical management options exist, detailed imaging analysis and comprehension of the various surgical and non-surgical interventions are crucial for surgical planning and postoperative evaluation. However, patients often present with recurrent or new symptoms after surgery, where MR imaging is necessary to detect complications in this setting. We aimed to analyze MR images pre- and postoperative/intervention using the defect-specific approach aiming at better understanding of the underlying complication and/or the cause of recurrence.

Results
Thirty female patients with SUI were included in the study; 20 underwent surgery, 6 were treated by physiotherapy only, while 3 patients underwent both surgery and physiotherapy and 1 patient was treated conservatively. According to their clinical symptoms, patients with successful surgical/physiotherapy outcome were 18 cases (60%), while unsuccessful group comprised of 12 cases (40%) is classified as follows: persistent complaints subgroup 7 patients (23.3%), de novo complaint subgroup 2 patients (6.7%), while the complicated subgroup is comprised of 2 patients (6.7%) and the persistent/de novo complaints subgroup of the unsuccessful group is composed of 1 case (3.3%). They all underwent MRI of the pelvic floor with a standardized technique, pre- and postoperative/physiotherapy. Changes in level III endopelvic fascia defects between the pre- and postoperative/physiotherapy studies were statistically significant (p = 0.045). Urinary bladder and uterine descent were also found statistically significant between the pre- and postoperative/physiotherapy studies (p = 0.001 and p = 0.029, respectively). Comparing successful and unsuccessful groups pre- and postoperative/therapy, levator plate angle (LPA) was found statistically significant as well (p = 0.039 preoperative and p = 0.001 postoperative).

Conclusions
Analysis of the pre- and postoperative static and dynamic MRI sequences along with proper understanding of the preformed intervention can pinpoint the underlying pathology leading to the recurrent or de novo symptom and/or complications. The defect-specific approach can help determine the underlying pelvic floor defect by altering the MRI techniques tailored for each patient according to their complaint.
Role of GSDMD and VEGF in differentiating between malignant and non-malignant pleural effusions
Authors: El-Kalashy Mai Mahmoud , Eid Hanaa Abdelmohsen , Awad Samah Mohammed , Allam Esraa Tawfik , Hassan Reham Ahmed Abdelaziz , El-Koa Amal Ali 
Published: March 2023

Abstract
Background
It is crucial to differentiate between benign and malignant pleural effusions while making a diagnosis. The purpose of this research was to investigate the diagnostic significance of GSDMD and VEGF in discriminating between different kinds of pleural effusion and their correlation with both progression-free and overall survivals in the malignant type.

Methods
Ninety-one pleural fluid samples, which were classified as transudates or exudates (tuberculous, para-infectious, or malignant) by pleural fluid classifications, were tested for GSDMD using sandwich ELIZA kits, and 41 of the exudative samples were randomly selected for VEGF testing. Both markers' diagnostic accuracy was assessed.

Results
The lowest level of GSDMD was associated with the transudate group (mean and SD of 2.35 ± 0.44 ng/mL) and the highest in the malignant effusion group (mean and SD of 4.38 ± 1.67 ng/mL). The specificity and sensitivity of GSDMD in the diagnosis of exudative PE were 97% and 98%, respectively (p = 0.001) with the cutoff point = 2.89). Regarding VEGF, its level was 222.3 ± 53.4 pg/ml for all studied samples where MPE (n = 21) was 261.2 ± 48.2 pg/ ml (mean ± SD), TBPE (n = 7) was 185.4 ± 6.96 pg/ml (mean ± SD), and PIPE (n = 13) was 179.3 ± 13.9 pg/ml (mean ± SD). The diagnostic accuracy of VEGF for the detection of MPE was 90% with a sensitivity of 100% and specificity of 80% and the cutoff point was 191.5 pg/ml. There were highly significant inverse correlations between progression-free survival and both GSDMD (r =− 0.531, p = 0.009) and VEGF (r = − 0.582, p = 0.006) in MPE.

Conclusion
Pleural effusion GSDMD can be an effective marker for differentiating the different kinds of PE, and VEGF levels can be a useful adjuvant marker in screening out MPE as a possible diagnosis, leading to the proper selection of patients who may benefit from more invasive procedures.
Lung cancer in the emergency department
Authors: Walder Jeremy R. , Faiz Saadia A. , Sandoval Marcelo 
Published: March 2023

Abstract
Background
Though decreasing in incidence and mortality in the USA, lung cancer remains the deadliest of all cancers. For a significant number of patients, the emergency department (ED) provides the first pivotal step in lung cancer prevention, diagnosis, and management. As screening recommendations and treatments advance, ED providers must stay up-to-date with the latest lung cancer recommendations. The purpose of this review is to identify the many ways that emergency providers may intersect with the disease spectrum of lung cancer and provide an updated array of knowledge regarding detection, management, complications, and interdisciplinary care.

Findings
Lung cancer, encompassing 10–12% of cancer-related emergency department visits and a 66% admission rate, is the most fatal malignancy in both men and women. Most patients presenting to the ED have not seen a primary care provider or undergone screening. Ultimately, half of those with a new lung cancer diagnosis in the ED die within 1 year. Incidental findings on computed tomography are mostly benign, but emergency staff must be aware of the factors that make them high risk. Radiologic presentations range from asymptomatic nodules to diffuse metastatic lesions with predominately pulmonary symptoms, and some may present with extra-thoracic manifestations including neurologic. The short-term prognosis for ED lung cancer patients is worse than that of other malignancies. Screening offers new hope through earlier diagnosis but is underutilized which may be due to racial and socioeconomic disparities. New treatments provide optimism but lead to new complications, some long-term. Multidisciplinary care is essential, and emergency medicine is responsible for the disposition of patients to the appropriate specialists at inpatient and outpatient centers.

Conclusion
ED providers are intimately involved in all aspects of lung cancer care. Risk factor modification and referral for lung cancer screening are opportunities to further enhance patient care. In addition, with the advent of newer cancer therapies, ED providers must stay vigilant and up-to-date with all aspects of lung cancer including disparities, staging, symptoms of disease, prognosis, treatment, and therapy-related complications.
Adding boundary terms to Anderson localized Hamiltonians leads to unbounded growth of entanglement
Authors: Huang Yichen 
Published: March 2023

Abstract
It is well known that in Anderson localized systems, starting from a random product state the entanglement entropy remains bounded at all times. However, we show that adding a single boundary term to an Anderson localized Hamiltonian leads to unbounded growth of entanglement. Our results imply that Anderson localization is not a local property. One cannot conclude that a subsystem has Anderson localized behavior without looking at the whole system, as a term that is arbitrarily far from the subsystem can affect the dynamics of the subsystem in such a way that the features of Anderson localization are lost.
Over-expressing NadA quinolinate synthase inEscherichia colienhances the bioelectrochemistry in microbial fuel cells
Authors: Guo Zhenyu , Wang Lei , Yu Changyuan 
Published: March 2023

ABSTRACTThe microbial fuel cell (MFC), which converts biomass energy into electricity through microbial metabolism, is one of the important devices for generating new bioenergy. However, low power production efficiency limits the development of MFCs. One possible method to solve this problem is to genetically modify the microbial metabolism pathways to enhance the efficiency of MFCs. In this study, we over-expressed the nicotinamide adenine dinucleotide A quinolinate synthase gene (nadA) in order to increase the NADH/+ level in Escherichia coli and obtain a new electrochemically active bacteria strain. The following experiments showed an enhanced performance of the MFC, including increased peak voltage output (70.81 mV) and power density (0.29 μW/cm2), which increased by 361% and 20.83% compared to the control group, respectively. These data suggest that genetic modification of electricity producing microbes could be a potential way to improve MFC performance.
Membrane tethers at a glance
Authors: Szentgyörgyi Viktória , Spang Anne 
Published: March 2023

ABSTRACT
Cargo delivery from one compartment to the next relies on the fusion of vesicles with different cellular organelles in a process that requires the concerted action of tethering factors. Although all tethers act to bridge vesicle membranes to mediate fusion, they form very diverse groups as they differ in composition, and in their overall architecture and size, as well as their protein interactome. However, their conserved function relies on a common design. Recent data on class C Vps complexes indicates that tethers play a significant role in membrane fusion beyond vesicle capturing. Furthermore, these studies provide additional mechanistic insights into membrane fusion events and reveal that tethers should be considered as key players of the fusion machinery. Moreover, the discovery of the novel tether FERARI complex has changed our understanding of cargo transport in the endosomal system as it has been shown to mediate ‘kiss-and-run’ vesicle–target membrane interactions. In this Cell Science at a Glance and the accompanying poster, we compare the structure of the coiled-coil and the multisubunit CATCHR and class C Vps tether families on the basis of their functional analogy. We discuss the mechanism of membrane fusion, and summarize how tethers capture vesicles, mediate membrane fusion at different cellular compartments and regulate cargo traffic.