bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth response of kale (Brassica oleracea) and Nile tilapia (Oreochromis niloticus) under saline aqua-sandponics-vegeculture system
Authors: Kimera Fahad , Mugwanya Muziri , Dawood Mahmoud , Sewilam Hani 
Published: February 2023

AbstractSalinity and freshwater scarcity are significant challenges affecting agriculture production worldwide. Sustaining food production in arid and semi-arid regions requires innovative, efficient, and low-cost technologies. Integrated aqua-vegeculture systems (IAVS) are promising technologies for cultivating vegetable crops and rearing fish and in a closed-loop system. The system utilizes fish effluents as crop fertilizers and recycles water for increased productivity. Hence, the current study aimed to investigate the response and productivity of kale (Brassica oleracea L.) grown at different brackish water salinities in an IAVS. The greenhouse experiment followed a completely randomized design with three salinity variants (i.e., 3000, 6000, and 9000 ppm) and control (freshwater, 400 ppm) with four replicates per treatment. The study results indicated that kale grown in a greenhouse could tolerate salinity levels of up to 6000 ppm without significantly compromising the plants’ growth, yield, and nutritional composition of leaves. Likewise, rearing Oreochromis niloticus at high water salinities did not negatively impact the water quality and the growth performance, survival, and feed utilization of fish. Overall, cultivating kale and rearing O. niloticus in IAVS in water salinities reaching up to 6000 ppm could be a sustainable agricultural strategy to increase food production in regions affected by freshwater scarcity.
Railway infrastructure maintenance efficiency improvement using deep reinforcement learning integrated with digital twin based on track geometry and component defects
Authors: Sresakoolchai Jessada , Kaewunruen Sakdirat 
Published: February 2023

AbstractRailway maintenance is a complex and complicated task in the railway industry due to the number of its components and relationships. Ineffective railway maintenance results in excess cost, defective railway structure and components, longer possession time, poorer safety, and lower passenger comfort. Of the three main maintenance approaches, predictive maintenance is the trendy one, and is proven that it provides the highest efficiency. However, the implementation of predictive maintenance for the railway industry cannot be done without an efficient tool. Normally, railway maintenance is corrective when some things fail or preventive when maintenance is routine. A novel approach using an integration between deep reinforcement learning and digital twin is proposed in this study to improve the efficiency of railway maintenance which other techniques such as supervised and unsupervised learning cannot provide. In the study, Advantage Actor Critic (A2C) is used to develop a reinforcement learning model and agent to fulfill the need of the study. Real-world field data over four years and 30 km. is obtained and applied for developing the reinforcement learning model. Track geometry parameters, railway component defects, and maintenance activities are used as parameters to develop the reinforcement learning model. Rewards (or penalties) are calculated based on maintenance costs and occurring defects. The new breakthrough exhibits that using reinforcement learning integrated with digital twin can reduce maintenance activities by 21% and reduce the occurring defects by 68%. Novelties of the study are the use of A2C which is faster and provides better results than other traditional techniques such as Deep Q-learning (DQN), each track geometry parameter is considered without combining into a track quality index, filed data are used to develop the reinforcement learning model, and seven independent actions are included in the reinforcement learning model. This study is the world’s first to contribute a new guideline for applying reinforcement learning and digital twins to improve the efficiency of railway maintenance, reduce the number of defects, reduce the maintenance cost, reduce the possession time for railway maintenance, improve the overall safety of the railway operation, and improve the passenger comfort which can be seen from its results.
Atmospheric–ocean coupling drives prevailing and synchronic dispersal patterns of marine species with long pelagic durations
Authors: Ramirez-Romero Eduardo , Amores Angel , Diaz David , Muñoz Anabel , Catalan Ignacio A. , Molinero Juan Carlos , Ospina-Alvarez Andres 
Published: February 2023

AbstractDispersal shapes population connectivity and plays a critical role in marine metacommunities. Prominent species for coastal socioecological systems, such as jellyfish and spiny lobsters, feature long pelagic dispersal phases (LPDPs), which have long been overlooked. Here, we use a cross-scale approach combining field surveys of these species with a high-resolution hydrodynamic model to decipher the underlying mechanisms of LPDP patterns in northwestern Mediterranean shores. We identified basin-scale prevailing dispersal routes and synchronic year-to-year patterns tightly linked to prominent circulation features typical of marginal seas and semienclosed basins, with an outstanding role of a retentive source area replenishing shores and potentially acting as a pelagic nursery area. We show how the atmospheric forcing of the ocean, a marked hydrological driver of the Mediterranean Sea, modulates dispersal routes and sources of LPDP at interannual scales. These findings represent a crucial advance in our understanding of the functioning of metapopulations of species with LPDP in marginal seas and may contribute to the effective management of coastal ecosystem services in the face of climate change.
Integrative competing endogenous RNA network analyses identify novel lncRNA and genes implicated in metastatic breast cancer
Authors: Jayarathna Dulari K. , Rentería Miguel E. , Batra Jyotsna , Gandhi Neha S. 
Published: February 2023

AbstractCompeting endogenous RNAs (ceRNAs) have gained attention in cancer research owing to their involvement in microRNA-mediated gene regulation. Previous studies have identified ceRNA networks of individual cancers. Nevertheless, none of these studies has investigated different cancer stages. We identify stage-specific ceRNAs in breast cancer using the cancer genome atlas data. Moreover, we investigate the molecular functions and prognostic ability of ceRNAs involved in stage I–IV networks. We identified differentially expressed candidate ceRNAs using edgeR and limma R packages. A three-step analysis was used to identify statistically significant ceRNAs of each stage. Survival analysis and functional enrichment analysis were conducted to identify molecular functions and prognostic ability. We found five genes and one long non-coding RNA unique to the stage IV ceRNA network. These genes have been described in previous breast cancer studies. Genes acted as ceRNAs are enriched in cancer-associated pathways. Two, three, and three microRNAs from stages I, II, and III were prognostic from the Kaplan–Meier survival analysis. Our results reveal a set of unique ceRNAs in metastatic breast cancer. Further experimental work is required to evaluate their role in metastasis. Moreover, identifying stage-specific ceRNAs will improve the understanding of personalised therapeutics in breast cancer.
Reliability of coracohumeral distance and subcoracoid tendons in subacromial pain syndrome
Authors: Cavaggion Claudia , Navarro-Ledesma Santiago , Juul-Kristensen Birgit , Luque-Suarez Alejandro , Voogt Lennard , Struyf Filip 
Published: February 2023

AbstractThis study investigated the intra-rater reliability of a novice ultrasound (US) examiner and the inter-rater reliability of two examiners (novice, expert) in the measures of coracohumeral distance at rest (CHD) and at 60° of elevation without (CHD60) or with weights (CHD60w), tendon thickness of the long head of the biceps (LHB) and subscapularis (SCP). Twenty-one patients with subacromial pain syndrome (SAPS) and 20 asymptomatic participants were included. Intra and inter-rater reliability were tested with intraclass-correlation-coefficient (ICC), differences between raters were analyzed with Bland–Altman plots. Intra-rater reliability for CHD, CHD60 and CHD60w was excellent (ICC = 0.97–0.98) in asymptomatic participants, and good-to-excellent (0.88–0.93) in SAPS, while intra-rater reliability for LHB and SCP was good-to-excellent in asymptomatic participants (0.88–0.97) and in SAPS (0.90–0.92). Inter-rater reliability for CHD, CHD60 and CHD60w was moderate-to-good (0.70–0.90) in asymptomatic participants and good (0.85–0.87) in SAPS, in contrast inter-rater reliability for LHB and SCP was poor in asymptomatic participants (0.10–0.46) and poor-to-moderate (0.49–0.61) in SAPS. Bland–Altman plots revealed systematic and/or proportional bias for tendons’ thickness. A novice showed good-to-excellent intra-rater reliability in all US measures, whereas in comparison to an expert a novice can measure reliably CHD, CHD60 and CHD60w, but not LHB and SCP, where more training is recommended.
Detection of a reduced susceptibility to chlorfenapyr in the malaria vector Anopheles gambiae contrasts with full susceptibility in Anopheles funestus across Africa
Authors: Tchouakui Magellan , Assatse Tatiane , Tazokong Hervé R. , Oruni Ambrose , Menze Benjamin D. , Nguiffo-Nguete Daniel , Mugenzi Leon M. J. , Kayondo Jonathan , Watsenga Francis , Mzilahowa Themba , Osae Michael , Wondji Charles S. 
Published: February 2023

AbstractNew insecticides have recently been produced to help control pyrethroid-resistant malaria vectors including the pyrrole, chlorfenapyr. Monitoring the susceptibility of mosquito populations against this new product and potential cross-resistance with current insecticides is vital for better resistance management. In this study, we assessed the resistance status of the major malaria vectors Anopheles gambiae and Anopheles funestus to chlorfenapyr across Africa and explored potential cross-resistance with known pyrethroid resistance markers. Efficacy of chlorfenapyr 100 µg/ml against An. gambiae and An. funestus from five Cameroonian locations, the Democratic Republic of Congo, Ghana, Uganda, and Malawi was assessed using CDC bottle assays. Synergist assays were performed with PBO (4%), DEM (8%) and DEF (0.25%) and several pyrethroid-resistant markers were genotyped in both species to assess potential cross-resistance between pyrethroids and chlorfenapyr. Resistance to chlorfenapyr was detected in An. gambiae populations from DRC (Kinshasa) (mortality rate: 64.3 ± 7.1%) Ghana (Obuasi) (65.9 ± 7.4%), Cameroon (Mangoum; 75.2 ± 7.7% and Nkolondom; 86.1 ± 7.4). In contrast, all An. funestus populations were fully susceptible. A negative association was observed between the L1014F-kdr mutation and chlorfenapyr resistance with a greater frequency of homozygote resistant mosquitoes among the dead mosquitoes after exposure compared to alive (OR 0.5; P = 0.02) whereas no association was found between GSTe2 (I114T in An. gambiae; L119F in An. funestus) and resistance to chlorfenapyr. A significant increase of mortality to chlorfenapyr 10 µg/ml was observed in An. funestus after to PBO, DEM and DEF whereas a trend for a decreased mortality was observed in An. gambiae after PBO pre-exposure. This study reveals a greater risk of chlorfenapyr resistance in An. gambiae populations than in An. funestus. However, the higher susceptibility in kdr-resistant mosquitoes points to higher efficacy of chlorfenapyr against the widespread kdr-based pyrethroid resistance.
Herpes zoster and long-term vascular risk: a retrospective cohort study
Authors: Horev Amir , Horev Anat , Gordon-Irshai Adi , Gordon Michal , Andre Nicolas , Ifergane Gal 
Published: February 2023

AbstractHerpes zoster (HZ) represents a serious health problem in the general population due to its abundance and complications. Stroke and acute myocardial infarction are well-documented short-term complications of HZ, primarily due to vasculopathy in the cerebral and coronary arteries. However, no major study to date has specifically demonstrated that HZ is a long-term risk factor for all Major Adverse Cardiac and Cerebrovascular Events (MACCE). A retrospective cohort study was conducted analyzing the association between HZ and MACCE. We compared HZ patients diagnosed between 2001 and 2018 and a matched control group. The model was stratified according to matched pairs and adjusted for age, socioeconomic status, history of dyslipidemia, and prior myocardial infarction (MI). Association between HZ exposure and stroke was assessed through a multivariable Cox regression analysis. The study included 41,930 patients, with 20,965 patients in each group. The risk of MACCE was 19% higher among HZ patients in the first year of follow up (P < 0.001). Antiviral treatment did not positively affect long-term survival among HZ patients (P < 0.001). These results suggest that HZ is a marker of long-term vascular risk. Additional studies will be needed to further evaluate this risk, the impact of HZ vaccination on such risk, and potential mitigation strategies.
Hyperspectral image reconstruction from colored natural flame luminosity imaging in a tri-fuel optical engine
Authors: Cheng Qiang , Karimkashi Shervin , Ahmad Zeeshan , Kaario Ossi , Vuorinen Ville , Larmi Martti 
Published: February 2023

AbstractThe detection of chemiluminescence from various radicals and molecules in a hydrocarbon flame can provide valuable information on the rate of local heat release, combustion stability, and combustion completeness. In this study, chemiluminescence from the combustion process is detected using a high-speed color camera within the broadband spectrum of visible light. Whereon, a novel hyperspectral reconstruction approach based on the physically plausible spectral reconstruction (PPSR) is employed to reconstruct the spectral chemiluminescence signals from 400 to 700 nm with a resolution of 10 nm to provide 31 different spectral channels. The reconstructed key chemiluminescence signals (e.g., CH*, CH2O*, C2*, and CO2*) from the color images are further analyzed to characterize the chemical kinetics and combustion processes under engine conditions. The spectral chemiluminescence evolution with engine crank angle is identified to comprehend the effect of H2 fraction on flame characteristics and combustion kinetics. Additionally, in this study, a detailed kinetic mechanism is adopted to deepen the theoretical understanding and describe the spectral chemiluminescence from H2/CH4 and H2/CH4/n-dodecane flames at relevant conditions for various species including OH*, CH*, C2*, and CO2*. The results indicate that the PPSR is an adequately reliable approach to reconstructing spectral wavelengths based on chemiluminescence signals from the color images, which can potentially provide qualitative information about the evolution of various species during combustion. Here, the reconstructed chemiluminescence images show less than 1% errors compared to the raw images in red, green, and blue channels. Furthermore, the reconstructed chemiluminescence trends of CH*, CH2O*, C2*, and CO2* show a good agreement with the detailed kinetics 0D simulation.
Colorimetry characteristics and color contribution of fluorescence in natural Cr-containing spinel
Authors: Tang Jun , Guo Ying , Zhang Jun 
Published: February 2023

AbstractFluorescence plays an important role in determining the color appearance of fluorescing minerals. This paper discusses the color mechanism in the red spinel and the color effects from the light source as well as the background on the spinel color. Excitation-Emission Matrices (EEMs) fluorescence spectroscopy was utilized to characterize the fluorescence of natural Cr-doped magnesia-alumina spinel from Myanmar. EMP, LA-ICP-MS, and optical spectroscopy were applied to study the spinel's chemical compositions and color mechanism. X-Rite Ci-7800 spectrophotometer, which is useful to measure colors for fluorescing minerals, was employed to acquire color data of spinel in daylight and incandescent light. The results indicated the higher value of Cr/Fe makes pinkish-red spinel has a much stronger red fluorescence effect than dark-red spinel. The two narrow absorption bands at ~ 25,500 cm−1 (with a broad absorption band at ~ 24,100 cm−1) and ~ 18,570 cm−1 in the optical absorption spectrum are assigned to spin-allowed electronic d-d transitions 4A2g → 4T1g(F) and 4A2g → 4T2g(F) in Cr3+ at the M site. The EEMs spectra of the pinkish-red spinels show twin emissions at 706 nm excited both by ~ 380 nm and ~ 535 nm radiations, which is the key to the bright neon red color in pinkish-red spinel. The colorimetry study suggests the strong red fluorescence produced by < 460 nm radiation contributes more than 10% lightness and chroma in pinkish-red spinel under daylight. The lightness and the chroma of the spinels grow with the decrease of the background grayscale. The differentiation of spinel colors in dark conditions is lower than that in a bright environment.
Location and size selection using hybrid Jaya‐Luus‐Jaakola algorithm for decentralized generations in distribution system considering demand‐side management
Authors: Meena V. P. , Yadav U. K. , Mathur Akhilesh , Singh V. P. , Guerrero Josep M. , Khan Baseem 
Published: February 2023

AbstractIn the distribution system, decentralized generation is incorporated to maximize the system reliability and economic stability, and to avoid redundancy in system. The efficient implementation of distributed‐generations (DGs) in a distribution‐system (DS) can be done by employing demand‐side management (DSM). In this research proposal, location and size selection of DGs in a DS considering DSM is accomplished using a hybrid Jaya‐Luus‐Jaakola (JLJ) algorithm. The hybridization of Jaya algorithm (JA) with Luus‐Jaakola algorithm (LJA) is done with a view to improving the rate of convergence of the algorithm. Three design objectives of minimization of active power loss and voltage deviation along with maximization of voltage stability index are considered in this research proposal. These design objectives under consideration are integrated together to form a problem of a single objective by assignments of weights. The formulated problem is minimized using proposed hybrid algorithm subjected to system constraints such as balance of power, limits on bus voltage and line capacity, and generation level of DGs. A static penalty is added to the formulated problem in case of any constraint violations. A photo‐voltaic‐based DG is used in the 33‐bus standard radial‐distribution‐system (RDS). A DSM scenario is created by shifting some loads of peak hours to off‐peak hours in view of minimizing the total cost of generation. The potency and superiority of the proposed algorithm is validated with the help of comparison of the results obtained by exploiting proposed method with results acquired from available state‐of‐art algorithms in literature. The comparison proves the comparative superior performance of the proposed algorithm.
Prähabilitation bei elektiver Lungen-Teilresektion (PRELS) – Eine Machbarkeitsstudie
Authors: Rechberger Sandra , Unger Ines , Greco Nico , Leuenberger Joachim M. Schmidt , Suter Peter , Wirz Markus 
Published: February 2023

Zusammenfassung
Hintergrund Lungenkrebs weist die höchste krebsbedingte Sterblichkeitsrate auf. Die chirurgische Resektion bei nicht kleinzelligem Lungenkrebs im Frühstadium bildet den Grundstein der Behandlung. Thoraxchirurgische Eingriffe sind mit einer erhöhten Rate an postoperativen Komplikationen verbunden, insbesondere bei verminderter präoperativer Leistungsfähigkeit. Das Enhanced Recovery Protocol stellt einen evidenzbasierten Ansatz für die Versorgung von Patient*innen dar, wobei ein wachsendes Interesse am Wert der Prähabilitation besteht. Prähabilitationsprotokolle, die auf eine Verbesserung der postoperativen Genesung abzielen, wurden als eine Intervention zur Verringerung der post-chirurgischen Beschwerden vorgeschlagen. Bis heute gibt es in der Schweiz keine etablierten Protokolle für ein präoperatives, körperliches Training.
Ziel Untersuchung der Machbarkeit eines präoperativen Trainingsprogramms für Patient*innen mit geplanter Lungenteilresektion.
Methoden Im Rahmen einer multizentrischen Machbarkeitsstudie wurden an 4 Schweizer Kliniken je 1 Person in ein präoperatives Training aufgenommen. Die Intervention bestand aus einem ambulanten Übungsprogramm mit Krafttraining und High-Intensity Intervall-Ausdauertraining für mindestens 1 Woche vor dem chirurgischen Eingriff. Die Endpunkte der Studie waren die Durchführbarkeit der präoperativen Rehabilitation und der Assessments sowie eine erste Abschätzung der Effekte.
Ergebnisse 4 Patient*innen wurden eingeschlossen. In allen Kliniken begannen die Patient*innen 21,5 ± 3 Tage vor der Operation mit dem Training, es gab keine Trainingsunterbrechungen. Es wurden keine unerwünschten Ereignisse beobachtet, was darauf hinweist, dass das präoperative Bewegungstraining sicher ist. Das vorgesehene Studiendesign konnte eingehalten werden. Die ausgewählten funktionellen Assessments sind durchführbar, sicher und die Ergebnisse sind für die Studie geeignet. Die Rekrutierung erwies sich jedoch als große Herausforderung.
Diskussion Die Ergebnisse zeigen, dass ein präoperatives Training durchführbar ist. Um das Rekrutierungspotenzial voll auszuschöpfen, ist es notwendig, die Risikostratifizierung, die organisatorischen Abläufe der beteiligten Kliniken zu spezifizieren und eine hohe Kooperationsbereitschaft aller beteiligten Disziplinen sicherzustellen bzw. zu definieren.
Schlussfolgerung Ein präoperatives, intensives Training vor einer geplanten Lungenteilresektion in 4 großen Spitälern der Schweiz war machbar. Es zeigten sich positive Effekte bezüglich Kraft und Ausdauer, zudem fühlten sich die Patient*innen in dieser Phase gut betreut. Ängste und Bedenken konnten frühzeitig adressiert und besprochen werden. Die Machbarkeitsstudie lieferte wertvolle Erkenntnisse für das Protokoll einer nachfolgenden Effektivitätsstudie.
Efficacy of Work-Related Support Rehabilitation for Patients with
Cancer: A Meta-Analysis of Randomized Controlled Trials
Authors: Li Gang , Wang Bin , Hu Yunzhou , Wang Xiaolong 
Published: February 2023

Abstract
Introduction The efficacy of work-related support rehabilitation for
patients with cancer remains controversial. We conduct a systematic review and
meta-analysis to explore the influence of work-related support rehabilitation on
the quality of life in patients with cancer.
Methods We have searched Pubmed, Embase, Web of science, Ebsco, and
Cochrane library databases through August 2021 for randomized controlled trials
(RCTs) assessing the effect of work-related support rehabilitation on the
quality of life in patients with cancer. This meta-analysis is performed using
the random-effect model.
Results Four RCTs are included in the meta-analysis. Overall, compared
with usual care for cancer patients, work-related support is associated with
significantly improved quality of life physical score (PCS, standard mean
difference [SMD]=0.22; 95% confidence interval [CI]=0.06
to 0.37; P=0.005) and reduced quality of life pain
(SMD=−0.16; 95% CI=−0.31 to 0;
P=0.04), but showed no obvious impact on quality of life mental score
(MCS, SMD=0; 95% CI=−0.28 to 0.28;
P=0.98), time of return to work (SMD=−0.78; 95%
CI=−2.71 to 1.14; P=0.43), or the scores of work ability
(SMD=−0.01; 95% CI=−0.16 to 9.09;
P=0.13) and work limitation (SMD=0.12; 95%
CI=−0.16 to 0.40; P=0.41).
Conclusions Work-related support rehabilitation may be effective to
improve the quality of life of cancer patients.