bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost‐effectiveness of the ADVISE trial: An intraoperative OCT protocol in DMEK surgery
Authors: van der Zee Casper , Muijzer Marc B. , van den Biggelaar Frank J. H. M. , Nuijts Rudy M. M. A. , Delbeke Heleen , Dickman Mor. M. , Imhof Saskia M. , Wisse Robert P. L. 
Published: June 2023

AbstractThe intraoperative optical coherence tomography (iOCT) is recently introduced in Descemet membrane endothelial keratoplasty (DMEK) surgery, which aims to increase clinical performance and surgery safety. However, the acquisition of this modality is a substantial investment. The objective of this paper is to report on the cost‐effectiveness of an iOCT‐protocol in DMEK surgery with the Advanced Visualization in Corneal Surgery Evaluation (ADVISE) trial. This cost‐effectiveness analysis uses data 6 months postoperatively from the multicentre prospective randomized clinical ADVISE trial. Sixty‐five patients were randomized to usual care (n = 33) or the iOCT‐protocol (n = 32). Quality‐Adjusted Life Years (EQ‐5D‐5L), Vision‐related Quality of Life (NEI‐VFQ‐25) and self‐administered resources questionnaires were administered. Main outcome is the incremental cost‐effectiveness ratio (ICER) and sensitivity analyses. The iOCT protocol reports no statistical difference in ICER. For the usual care group compared with the iOCT protocol, respectively, the mean societal costs are €5027 compared with €4920 (Δ€107). The sensitivity analyses report the highest variability on time variables. This economic evaluation learned that there is no added value in quality of life or cost‐effectiveness in using the iOCT protocol in DMEK surgery. The variability of cost variables depends on the characteristics of an eye clinic. The added value of iOCT could gain incrementally by increasing surgical efficiency, and aiding in surgical decision‐making.
Very low birthweight infants receive less enteral feeding than what is prescribed
Authors: Immeli Lotta , Mäkelä Pauliina M. , Leskinen Markus , Sund Reijo , Andersson Sture , Luukkainen Päivi 
Published: June 2023

AbstractAimFeeding a very low birthweight (VLBW, <1500 g) infant is challenging. Our aims were to study how prescribed enteral feeding is implemented in VLBW infants and to identify factors associating with slow enteral feeding progression.MethodsOur retrospective cohort included 516 VLBW infants born before 32 weeks of gestation during 2005–2013 and admitted to Children's Hospital, Helsinki, Finland, for at least the two first weeks of life. Nutritional data were collected from birth until the age of 14–28 days, depending on the length of stay.ResultsWe found that enteral feeding progressed slower than recommended and implementation differed from the prescriptions, especially during the parenteral nutrition phase (milk intake 10–20 mL/kg/day): 71% [40–100], median [IQR], of the prescribed enteral milk was administered. The full prescribed amount was less likely administered if a higher volume of gastric residual was aspirated or if the infant did not pass stool during the same day. Longer opiate use, patent ductus arteriosus, respiratory distress syndrome and slower passage of the first meconium associated with slower enteral feeding progression.ConclusionEnteral feeding of a VLBW infant is often not administered as prescribed, which possibly plays a significant role in the slow progression of enteral feeding.
Robot‐assisted laparoscopic abdominoperineal resection for anal canal cancer associated with Crohn's disease: A case report
Authors: Yamashita Shinji , Okita Yoshiki , Kawamura Mikio , Uratani Ryo , Imaoka Hiroki , Shimura Tadanobu , Kitajima Takahito , Morimoto Yuhki , Yasuda Hiromi , Yoshiyama Shigeyuki , Okugawa Yoshinaga , Ohi Masaki , Toiyama Yuji 
Published: June 2023

AbstractA 37‐year‐old man with Crohn's disease (CD) and a history of abdominal surgery was diagnosed with anal canal cancer. Robot‐assisted laparoscopic abdominoperineal resection was performed and the patient was discharged without any postoperative complications. Recently, minimally invasive surgery for CD patients has grown in popularity. However, there have been few studies of robotic surgery for CD patients with anal canal cancer. To the best of our knowledge, we present the first report of a patient with CD‐associated anal canal cancer who underwent robot‐assisted laparoscopic abdominoperineal resection.
KIOS: A smartphone app for self‐monitoring for patients with bipolar disorder
Authors: Pahwa Mehak , McElroy Susan L. , Priesmeyer Richard , Siegel Gregg , Siegel Phyllis , Nuss Sharon , Bowden Charles L. , El‐Mallakh Rif S. 
Published: June 2023

AbstractObjectivesThis study examined the use of a self‐monitoring/self‐management smartphone application (app) for patients with bipolar disorder. The app was specifically designed with patient‐centered computational software system based on concepts from nonlinear systems (chaos) theory.MethodsThis was a randomized, active comparator study of use of the KIOS app compared to an existing free app that has high utilization rates known as eMoods, over 52 weeks, and performed in three academic centers. Patients were evaluated monthly utilizing the Bipolar Inventory of Symptoms Schedule (BISS). The primary outcome measure was the persistence of using the app over the year of the study.ResultsPatients assigned to KIOS persisted in the study longer than those assigned to eMoods; 57 patients (87.70%) in the KIOS group versus 42 (73.69%) in the eMoods group completed the study (p = 0.03). By 52 weeks, significantly more of KIOS group (84.4%) versus eMoods group (54%) entered data into their programs (χ2 = 14.2, df = 1, p = 0.0002). Patient satisfaction for KIOS was greater (F = 5.21, df = 1, 108, p = 0.025) with a standardized effect size (Cohen's d) of 0.41. There was no difference in clinical outcome at the end of the study between the two groups.ConclusionsThis is the first randomized comparison study comparing two apps for the self‐monitoring/self‐management of bipolar disorder. The study revealed greater patient satisfaction and greater adherence to a patient‐centered software program (KIOS) than a monitoring program that does not provide feedback (eMoods).
Coral recruitment: patterns and processes determining the dynamics of coral populations
Authors: Edmunds Peter J. 
Published: June 2023

ABSTRACTCoral recruitment describes the addition of new individuals to populations, and it is one of the most fundamental demographic processes contributing to population size. As many coral reefs around the world have experienced large declines in coral cover and abundance, there has been great interest in understanding the factors causing coral recruitment to vary and the conditions under which it can support community resilience. While progress in these areas is being facilitated by technological and scientific advances, one of the best tools to quantify recruitment remains the humble settlement tile, variants of which have been in use for over a century. Here I review the biology and ecology of coral recruits and the recruitment process, largely as resolved through the use of settlement tiles, by: (i) defining how the terms ‘recruit’ and ‘recruitment’ have been used, and explaining why loose terminology has impeded scientific advancement; (ii) describing how coral recruitment is measured and why settlement tiles have value for this purpose; (iii) summarizing previous efforts to review quantitative analyses of coral recruitment; (iv) describing advances from hypothesis‐driven studies in determining how refuges, seawater flow, and grazers can modulate coral recruitment; (v) reviewing the biology of small corals (i.e. recruits) to understand better how they respond to environmental conditions; and (vi) updating a quantitative compilation of coral recruitment studies extending from 1974 to present, thus revealing long‐term global declines in density of recruits, juxtaposed with apparent resilience to coral bleaching. Finally, I review future directions in the study of coral recruitment, and highlight the need to expand studies to deliver taxonomic resolution, and explain why time series of settlement tile deployments are likely to remain pivotal in quantifying coral recruitment.
Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response
Authors: Zubčić Klara , Franić Dina , Pravica Mihaela , Hof Patrick R. , Šimić Goran , Boban Mirta 
Published: June 2023

AbstractBackgroundThe primary histological characteristic of Alzheimer's disease is the presence of neurofibrillary tangles, which are large aggregates of tau protein. Aging is the primary risk factor for the development of Alzheimer's disease, however, the underlying causes of tau protein aggregation and toxicity are unclear.AimsHere we investigated tau aggregation and toxicity under the conditions of compromised protein homeostasis.MethodsWe used heterologous expression of human tau protein in the unicellular eukaryote yeast Saccharomyces cerevisiae with evolutionarily conserved protein quality control pathways and examined tau‐dependent toxicity and aggregation using growth assays, fluorescence microscopy, and a split luciferase‐based reporter NanoBiT.ResultsTau protein expressed in yeast under mild proteotoxic stress, or in mutants with impaired pathways for proteotoxic stress response, did not lead to synthetic toxicity or the formation of obvious aggregates. Chronologically old cells also did not develop observable tau aggregates. Our examination of tau oligomerization in living cells using NanoBiT reporter suggests that tau does not form significant levels of oligomers under basal conditions or under mild proteotoxic stress.ConclusionTogether our data suggest that human tau protein does not represent a major burden to the protein quality control system in yeast cells.
Expression analysis of MMP14: Key enzyme action in modulating visceral adipose tissue plasticity in patients with obesity
Authors: Sachan Astha , Aggarwal Sandeep , Pol Manjunath Maruti , Singh Archna , Yadav Rakhee 
Published: June 2023

SummaryCompromised adipose tissue plasticity is a hallmark finding of obesity orchestrated by the intricate interplay between various extracellular matrix components. Collagen6 (COL6) is well characterized in obese visceral adipose tissue (VAT), not much is known about MMP14 which is hypothesized to be the key player in matrix reorganization. Subjects with obesity (BMI ≥40; n = 50) aged 18–60 years undergoing bariatric surgery and their age‐matched controls (BMI < 25; n = 30) were included. MMP14, Col6A3 and Tissue inhibitor of metalloproteinase 2 (TIMP2) mRNA expression was assessed in VAT and their serum levels along with endotrophin were estimated in both groups preoperatively and post‐operatively in the obese group. The results were analysed statistically and correlated with anthropometric and glycaemic parameters, namely fasting glucose and insulin, HbA1c, HOMA‐IR, HOMA‐β and QUICKI. Circulating levels as well as mRNA expression profiling revealed significant differences between the individuals with and without obesity (p < .05), more so in individuals with diabetes and obesity (p < .05). Follow‐up serum analysis revealed significantly raised MMP14 (p < .001), with decreased Col6A3, endotrophin and TIMP2 levels (p < .01, p < .001 and p < .01, respectively). A rise in serum MMP14 protein, simultaneous with post‐surgical weight loss and decreased serum levels of associated extracellular matrix (ECM) remodellers, suggests its crucial role in modulating obesity‐associated ECM fibrosis and pliability of VAT.
Liquid biopsy: A promising tool for driving strategies and predicting failures in patients with classic Hodgkin lymphoma
Authors: Pepe Francesco , Giordano Claudia , Russo Gianluca , Palumbo Lucia , Vincenzi Annamaria , Acanfora Gennaro , Lisi Dario , Picardi Marco , Pane Fabrizio , Troncone Giancarlo , Vigliar Elena 
Published: June 2023

AbstractClassic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological disorders that covers undifferentiated B cell neoplasms originating from germinal centre B cells. The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed–Sternberg cells mixed with a plethora of non‐tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow‐up, and response prediction.
Developmental shift in testosterone influence on prefrontal emotion control
Authors: Tyborowska Anna , Volman Inge , Niermann Hannah C. M. , Dapprich Anna L. , Smeekens Sanny , Cillessen Antonius H. N. , Toni Ivan , Roelofs Karin 
Published: June 2023

AbstractA paradox of testosterone effects is seen in adolescents versus adults in social emotional approach‐avoidance behavior. During adolescence, high testosterone levels are associated with increased anterior prefrontal (aPFC) involvement in emotion control, whereas during adulthood this neuro‐endocrine relation is reversed. Rodent work shows that, during puberty, testosterone transitions from a neuro‐developmental to a social‐sexual activating hormone. In this study, we explored whether this functional transition is also present in human adolescents and young adults. Using a prospective longitudinal design, we investigated the role of testosterone on neural control of social emotional behavior during the transitions from middle to late adolescence and into young adulthood. Seventy‐one individuals (tested at ages 14, 17, and 20 years) performed an fMRI‐adapted approach‐avoidance (AA) task involving automatic and controlled actions in response to social emotional stimuli. In line with predictions from animal models, the effect of testosterone on aPFC engagement decreased between middle and late adolescence, and shifted into an activational role by young adulthood—impeding neural control of emotions. This change in testosterone function was accompanied by increased testosterone‐modulated amygdala reactivity. These findings qualify the testosterone‐dependent maturation of the prefrontal‐amygdala circuit supporting emotion control during the transition from middle adolescence into young adulthood.
Copenhagen Diabetes Consensus (CODIAC) 2021: User involvement in diabetes care, prevention and research
Authors: Bloch Paul , Dadaczynski Kevin , Grabowski Dan , Lomborg Kirsten , Olesen Kasper , Rasmussen Lauge Neimann , Rossing Peter , Varming Annemarie , Willaing Ingrid , Harris Janet , Holt Richard I. G. , Jensen Bjarne Bruun 
Published: June 2023

AbstractAimsUser involvement is pivotal for health development, but there are significant gaps in our understanding of the concept. The Copenhagen Diabetes Consensus on User Involvement in Diabetes Care, Prevention and Research (CODIAC) was established to address these gaps, share knowledge and develop best practices.MethodsA literature review of user involvement was undertaken in diabetes care, prevention and research. Moreover, a Group Concept Mapping (GCM) survey synthesized the knowledge and opinions of researchers, healthcare professionals and people with diabetes and their carers to identify gaps between what is important for user involvement and what is being done in practice. Finally, a consensus conference discussed the main gaps in knowledge and practice while developing plans to address the shortcomings.ResultsThe literature review demonstrated that user involvement is an effective strategy for diabetes care, prevention and research, given the right support and conditions, but gaps and key challenges regarding the value and impact of user involvement approaches were found. The GCM process identified 11 major gaps, where important issues were not being sufficiently practised. The conference considered these gaps and opportunities to develop new collaborative initiatives under eight overall themes.ConclusionsUser involvement is effective and adds value to diabetes care, prevention and research when used under the right circumstances. CODIAC developed new learning about the way in which academic and research knowledge can be transferred to more practice‐oriented knowledge and concrete collaborative initiatives. This approach may be a potential new framework for initiatives in which coherence of process can lead to coherent outputs.
Association between spirometry pattern, left ventricular diastolic function, and mortality
Authors: Huang Wei‐Ming , Chang Hao‐Chih , Lee Ching‐Wei , Huang Chi‐Jung , Yu Wen‐Chung , Cheng Hao‐Min , Guo Chao‐Yu , Chiang Chern‐En , Chen Chen‐Huan , Sung Shih‐Hsien 
Published: June 2023

AbstractBackgroundSpirometric abnormalities have been related to incident heart failure in general population, who generally have preserved left ventricular ejection fraction (LVEF). We aimed to investigate the association between spirometric indices, cardiac functions and clinical outcomes.MethodsSubjects presenting with exertional dyspnoea and received spirometry and echocardiography were eligible for this study. Forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1)/FVC ratio were measured to define the spirometry patterns: normal (FEV1/FVC ≥ 70%, FVC ≥ 80%), obstructive (FEV1/FVC < 70%, FVC ≥ 80%), restrictive pattern (FEV1/FVC ≥ 70%, FVC < 80%) and mixed (FEV1/FVC < 70%, FVC < 80%). The diastolic dysfunction index (DDi) was the counts of the indicators, including septal e′ velocity <7 cm/s, septal E/e′ > 15, pulmonary artery systolic pressure > 35 mmHg and left atrial dimension >40 mm.ResultsAmong a total of 8669 participants (65.8 ± 16.3 years, 56% men), 3739 (43.1%), 829 (9.6%), 3050 (35.2%) and 1051 (12.1%) had normal, obstructive, restrictive and mixed spirometry pattern, respectively. Subjects with restrictive or mixed spirometry pattern had higher DDi and worse long‐term survival than those with obstructive or normal ventilation. FVC but not FEV1/FVC was predictive of 5‐year mortality, independent of age, sex, renal function, LVEF, DDi, body mass index, and comorbidities (hazard ratio, 95% confidence intervals: .981, .977–.985). Furthermore, there was an inverse nonlinear relationship between FVC and DDi, suggesting the declined FVC may mediate 43% of the prognostic hazard of left ventricular diastolic dysfunction.ConclusionsThe restrictive spirometry pattern or the declined FVC was associated with left ventricular diastolic dysfunction, which aggravated the long‐term mortality in the ambulatory dyspnoeic subjects.
Systematic review of cuckoo bumblebee research reveals data gaps and understudied species
Authors: Dozier Amy Elizabeth , Straw Edward Alexander , Stanley Dara Anne 
Published: June 2023

Abstract
Cuckoo bumblebees (Bombus subgenus Psithyrus) are social parasites that have lost the ability to establish their own nests, and instead usurp the nest of a bumblebee host to reproduce. Accordingly, they are entirely dependent upon a host species to complete their life cycle, and are therefore vulnerable to co–extinction. Despite this, the current consensus is that there remains much we do not know about the fundamental ecology of many cuckoo bumblebee species, which is crucial for conservation.
To investigate data gaps for cuckoo bumblebees, we conducted a systematic review to quantify the peer‐reviewed literature that has been produced, including which species have been most studied and which disciplines have been explored.
Over half of all Psithyrus species were represented in fewer than 10 publications each, including 2 species listed as Critically Endangered by the IUCN.
Research on cuckoo bumblebees is heavily weighted towards Europe and European species, while Asian species were under‐represented.
Key research areas such as ecology and behaviour have received little attention for the majority of cuckoo bumblebees, which may hamper conservation efforts
Our results quantitatively support observations made in other publications on the scarcity of data on cuckoo bumblebees, and highlight the need for further research on many species for whom fundamental knowledge is missing—particularly in light of the vulnerability of this subgenus to extinction.
Cued motor processing in autism and typical development: A high‐density electrical mapping study of response‐locked neural activity in children and adolescents
Authors: Wakim Kathryn‐Mary , Foxe John J. , Molholm Sophie 
Published: June 2023

AbstractMotor atypicalities are common in autism spectrum disorder (ASD) and are often evident prior to classical ASD symptoms. Despite evidence of differences in neural processing during imitation in autistic individuals, research on the integrity and spatiotemporal dynamics of basic motor processing is surprisingly sparse. To address this need, we analysed electroencephalography (EEG) data recorded from a large sample of autistic (n = 84) and neurotypical (n = 84) children and adolescents while they performed an audiovisual speeded reaction time (RT) task. Analyses focused on RTs and response‐locked motor‐related electrical brain responses over frontoparietal scalp regions: the late Bereitschaftspotential, the motor potential and the reafferent potential. Evaluation of behavioural task performance indicated greater RT variability and lower hit rates in autistic participants compared to typically developing age‐matched neurotypical participants. Overall, the data revealed clear motor‐related neural responses in ASD, but with subtle differences relative to typically developing participants evident over fronto‐central and bilateral parietal scalp sites prior to response onset. Group differences were further parsed as a function of age (6–9, 9–12 and 12–15 years), sensory cue preceding the response (auditory, visual and bi‐sensory audiovisual) and RT quartile. Group differences in motor‐related processing were most prominent in the youngest group of children (age 6–9), with attenuated cortical responses observed for young autistic participants. Future investigations assessing the integrity of such motor processes in younger children, where larger differences may be present, are warranted.
Nitrogen transfer between plant species with different temporal N‐demand
Authors: Montesinos‐Navarro A. 
Published: June 2023

AbstractPhenological segregation among species in a community is assumed to promote coexistence, as using resources at different times reduces competition. However, other unexplored nonalternative mechanisms can also result in a similar outcome. This study first tests whether plants can redistribute nitrogen (N) among them based on their nutritional temporal demand (i.e. phenology). Field 15N labelling experiments showed that 15N is transferred between neighbour plants, mainly from low N‐demand (late flowering species, not reproducing yet) to high N‐demand plants (early flowering species, currently flowering‐fruiting). This can reduce species' dependence on pulses of water availability, and avoid soil N loss through leaching, having relevant implications in the structuring of plant communities and ecosystem functioning. Considering that species phenological segregation is a pervasive pattern in plant communities, this can be a so far unnoticed, but widely spread, ecological process that can predict N fluxes among species in natural communities, and therefore impact our current understanding of community ecology and ecosystem functioning.