bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of apolipoproteins and lipoprotein(a) with metabolic syndrome: a systematic review and meta-analysis
Authors: Ulloque-Badaracco Juan R. , Al-kassab-Córdova Ali , Hernandez-Bustamante Enrique A. , Alarcon-Braga Esteban A. , Huayta-Cortez Miguel , Carballo-Tello Ximena L. , Seminario-Amez Rosa A. , Herrera-Añazco Percy , Benites-Zapata Vicente A. 
Published: July 2023

Abstract
Background & aims
Apolipoproteins and lipoprotein(a) are associated with various cardiometabolic diseases, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, among others. This systematic review and meta-analysis was conducted to evaluate the association of these markers with metabolic syndrome (MetS).

Methods
We ran a systematic search through PubMed, Scopus, Embase, Ovid/Medline, and Web of Science on March 15, 2023. No language or date restrictions were applied. The only synthesised effect measure reported was the odds ratio (OR) with its corresponding 95% confidence interval (95% CI). We utilised the random-effects model for the quantitative synthesis.

Results
We analysed 50 studies (n = 150 519) with different definitions for MetS. Increased ApoB values were associated with MetS (OR = 2.8; 95% CI: 2.44–3.22; p < 0.01, I2 = 99%). Decreased ApoA1 values were associated with MetS (OR = 0.42; 95% CI: 0.38–0.47; p < 0.01, I2 = 99%). Increased values of the ApoB/ApoA1 ratio were associated with MetS (OR = 4.97; 95% CI: 3.83–6.44; p < 0.01, I2 = 97%). Decreased values of Lp(a) were associated with MetS (OR = 0.89; 95% CI: 0.82–0.96; p < 0.01; I2 = 92%).

Conclusions
Increased values of ApoB and ApoB/ApoA1 ratio are associated with MetS, while decreased values of ApoA1 and Lp(a) are associated with MetS. These findings suggest that these lipid markers may serve as potential indicators for identifying subjects at risk of developing MetS. However, further research is required to elucidate the underlying mechanisms of these associations.
RETRACTED ARTICLE: A pH/enzyme dual responsive PMB spatiotemporal release hydrogel promoting chronic wound repair
Authors: Dong Lanlan , Huang Can , Zhao Baohua , Hu Guangyun , Huang Yong , Zhang Xiaorong , Hu Xiaohong , Wang Ying , XiaoyanSun  , Qian Wei , Luo Gaoxing 
Published: July 2023

AbstractSuppressing persistent multidrug-resistant (MDR) bacterial infections and excessive inflammation is the key for treating chronic wounds. Therefore, developing a microenvironment-responsive material with good biodegradability, drug-loading, anti-infection, and anti-inflammatory properties is desired to boost the chronic wounds healing process; however, using ordinary assembly remains a defect. Herein, we propose a pH/enzyme dual-responsive polymyxin B (PMB) spatiotemporal-release hydrogel (GelMA/OSSA/PMB), namely, the amount of OSSA and PMB released from GelMA/OSSA/PMB was closely related the wound pH and the enzyme concentration changing. The GelMA/OSSA/PMB showed better biosafety than equivalent free PMB, owing to the controlled release of PMB, which helped kill planktonic bacteria and inhibit biofilm activity in vitro. In addition, the GelMA/OSSA/PMB exhibited excellent antibacterial and anti-inflammatory properties. A MDR Pseudomonas aeruginosa caused infection was effectively resolved by the GelMA/OSSA/PMB hydrogel in vivo, thereby significantly boosting wound closure during the inflammatory phase. Furthermore, GelMA/OSSA/PMB accelerated the sequential phases of wound repair.
Targeting lymph node delivery with nanovaccines for cancer immunotherapy: recent advances and future directions
Authors: Li Yueyi , Li Shen , Jiang Zedong , Tan Keqin , Meng Yuanling , Zhang Dingyi , Ma Xuelei 
Published: July 2023

AbstractAlthough cancer immunotherapy is a compelling approach against cancer, its effectiveness is hindered by the challenge of generating a robust and durable immune response against metastatic cancer cells. Nanovaccines, specifically engineered to transport cancer antigens and immune-stimulating agents to the lymph nodes, hold promise in overcoming these limitations and eliciting a potent and sustained immune response against metastatic cancer cells. This manuscript provides an in-depth exploration of the lymphatic system’s background, emphasizing its role in immune surveillance and tumor metastasis. Furthermore, it delves into the design principles of nanovaccines and their unique capability to target lymph node metastasis. The primary objective of this review is to provide a comprehensive overview of the current advancements in nanovaccine design for targeting lymph node metastasis, while also discussing their potential to enhance cancer immunotherapy. By summarizing the state-of-the-art in nanovaccine development, this review aims to shed light on the promising prospects of harnessing nanotechnology to potentiate cancer immunotherapy and ultimately improve patient outcomes.
The relationship between changes in neighborhood physical environment and changes in physical activity among children: a prospective cohort study
Authors: Acciai Francesco , DeWeese Robin S , Lloyd Kristen , Yedidia Michael J , Kennedy Michelle , DiSantis Katherine Isselmann , Tulloch David , Ohri-Vachaspati Punam 
Published: July 2023

Abstract
Background
Physical activity (PA) is associated with positive health outcomes over the entire life course. Many community-based interventions that promote PA focus on implementing incremental changes to existing facilities and infrastructure. The objective of this study was to determine if such upgrades were associated with increases in children’s PA.

Methods
Two cohorts of 3- to 15-year-old children (n = 599) living in 4 low-income New Jersey cities were followed during 2- to 5-year periods from 2009 to 2017. Data on children’s PA were collected at 2 time points (T1 and T2) from each cohort using telephone survey of parents; data on changes to existing PA facilities were collected yearly from 2009 to 2017 using Open Public Records Act requests, publicly available data sources, and interviews with key stakeholders. PA changes were categorized into six domains (PA facility, park, trail, complete street, sidewalk, or bike lane) and coded as new opportunity, renovated opportunity, or amenity. A scale variable capturing all street-related upgrades (complete street, sidewalk, and bike lane) was constructed. PA was measured as the number of days per week the child engaged in at least 60 min of PA. The association between change in PA between T1 and T2, ranging from − 7 to + 7, and changes to the PA environment was modeled using weighted linear regression controlling for PA at T1, child age, sex, race, as well as household and neighborhood demographic and socioeconomic characteristics.

Results
While most measures of the changes to the PA environment were not associated with change in PA between T1 and T2, the street-related upgrades were positively associated with the change in PA; specifically, for each additional standard deviation in street upgrades within a 1-mile radius of their homes, the change in PA was 0.42 (95% CI: 0.02, 0.82; p = 0.039) additional days. This corresponds to an 11% increase over the mean baseline value (3.8 days).

Conclusions
The current study supports funding of projects aimed at improving streets and sidewalks in cities, as it was shown that incremental improvements to the PA environment near children’s homes will likely result in increased PA among children.
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Authors: Dagar Gunjan , Gupta Ashna , Masoodi Tariq , Nisar Sabah , Merhi Maysaloun , Hashem Sheema , Chauhan Ravi , Dagar Manisha , Mirza Sameer , Bagga Puneet , Kumar Rakesh , Akil Ammira S. Al-Shabeeb , Macha Muzafar A. , Haris Mohammad , Uddin Shahab , Singh Mayank , Bhat Ajaz A. 
Published: July 2023

AbstractTraditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumor-associated antigens. CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. This review covers the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles, such as utilizing single-cell RNA sequencing and artificial intelligence to optimize clinical-grade CAR-T cells.
Change in activity patterns in the prefrontal cortex in different phases during the dual-task walking in older adults
Authors: Baek Chang Yoon , Kim Hyeong Dong , Yoo Dong Yup , Kang Kyoung Yee , Lee Jang Woo 
Published: July 2023

Abstract
Background
Studies using functional near-infrared spectroscopy (fNIRS) have shown that dual-task walking leads to greater prefrontal cortex (PFC) activation compared to the single-task walking task. However, evidence on age-related changes in PFC activity patterns is inconsistent. Therefore, this study aimed to explore the changes in the activation patterns of PFC subregions in different activation phases (early and late phases) during both single-task and dual-task walking in both older and younger adults.

Methods
Overall, 20 older and 15 younger adults performed a walking task with and without a cognitive task. The activity of the PFC subregions in different phases (early and late phases) and task performance (gait and cognitive task) were evaluated using fNIRS and a gait analyzer.

Results
The gait (slower speed and lower cadence) and cognitive performance (lower total response, correct response and accuracy rate, and higher error rate) of older adults was poorer during the dual task than that of younger adults. Right dorsolateral PFC activity in the early period in older adults was higher than that in younger adults, which declined precipitously during the late period. Conversely, the activity level of the right orbitofrontal cortex in the dual-task for older adults was lower than for younger adults.

Conclusions
These altered PFC subregion-specific activation patterns in older adults would indicate a decline in dual-task performance with aging.
Real-time contrast-enhanced ultrasound-guided percutaneous biopsy in the diagnosis of ovarian metastasis of gallbladder carcinoma: a case report
Authors: Wang Jing , Liu Yanjun , Sang Liang , Wan Weina 
Published: July 2023

Abstract
Background
Multiple-organ primary tumors can invade the ovary through lymphatic and hematogenous routes, presenting as ovarian Krukenberg tumors, but these rarely originate from the gallbladder. Krukenberg tumors can present similar to primary ovarian tumors; however, their treatments are completely different.

Patient concerns
A 62-year-old Chinese woman presented with abdominal distension for six months and weight loss of five kilograms for two months.

Diagnoses
Based on multiple imaging examinations, the patient was preliminarily diagnosed with a malignant tumor of unknown origin with multiple metastases (omentum). To identify the origin of the malignancy, the patient underwent real-time contrast-enhanced ultrasound-guided percutaneous biopsy. The results revealed a perihepatic hypoechoic lesion and right adnexal mass that were both metastatic adenocarcinomas from the gallbladder.

Interventions
The patient initially received chemotherapy with gemcitabine and cisplatin instead of surgery. However, the tumor increased in size on re-examination after two cycles, so the treatment was shifted to a combination regimen with durvalumab for six cycles.

Outcomes
The treatment proceeded smoothly, with no recurrence or obvious progression of the cancer during follow-up.

Conclusions
Differentiating between primary and metastatic ovarian tumors is important. Early diagnosis and effective treatment options are essential for patient survival. CEUS-guided percutaneous biopsy is a valuable procedure for patients with multiple metastases who cannot tolerate surgery.
Cangfu Daotan Wan alleviates polycystic ovary syndrome with phlegm-dampness syndrome via disruption of the PKP3/ERCC1/MAPK axis
Authors: Li Yuan , Wu Haicui , Guo Ying , Wei Chaofeng , Guan Lu , Ju Wenhan , Lian Fang 
Published: July 2023

AbstractBackground/AimCangfu Daotan Wan (CFDTW) has been widely used for polycystic ovary syndrome (PCOS) patients in the type of stagnation of phlegm and dampness. In this study, we aimed to evaluate the mechanism underlying the therapeutic effect of CFDTW on PCOS with phlegm-dampness syndrome (PDS).MethodsIn silicoanalysis was adopted to identify CFDTW potential targets and the downstream pathways in the treatment of PCOS. Expression of PKP3 was examined in the ovarian granulosa cells from PCOS patients with PDS and rat PCOS models induced by dehydroepiandrosterone (DHEA). PKP3/ERCC1 was overexpressed or underexpressed or combined with CFDTW treatment in ovarian granulosa cells to assay the effect of CFDTW on ovarian granulosa cell functionsviathe PKP3/MAPK/ERCC1 axis.ResultsClinical samples and ovarian granulosa cells of rat models were characterized by hypomethylated PKP3 promoter and upregulated PKP3 expression. CFDTW reduced PKP3 expression by enhancing the methylation of PKP3 promoter, leading to proliferation of ovarian granulosa cells, increasing S and G2/M phase-arrested cells, and arresting their apoptosis. PKP3 augmented ERCC1 expression by activating the MAPK pathway. In addition, CFDTW facilitated the proliferation of ovarian granulosa cells and repressed their apoptosis by regulating PKP3/MAPK/ERCC1 axis.ConclusionTaken together, this study illuminates how CFDTW confers therapeutic effects on PCOS patients with PDS, which may offer a novel theranostic marker in PCOS.
A novel method for assessment of airway opening pressure without the need for low-flow insufflation
Authors: Haudebourg Anne-Fleur , Moncomble Elsa , Lesimple Arnaud , Delamaire Flora , Louis Bruno , Mekontso Dessap Armand , Mercat Alain , Richard Jean-Christophe , Beloncle François , Carteaux Guillaume 
Published: July 2023

Abstract
Background
Airway opening pressure (AOP) detection and measurement are essential for assessing respiratory mechanics and adapting ventilation. We propose a novel approach for AOP assessment during volume assist control ventilation at a usual constant-flow rate of 60 L/min.

Objectives
To validate the conductive pressure (Pcond) method, which compare the Pcond—defined on the airway pressure waveform as the difference between the airway pressure level at which an abrupt change in slope occurs at the beginning of insufflation and PEEP—to resistive pressure for AOP detection and measurement, and to compare its respiratory and hemodynamic tolerance to the standard low-flow insufflation method.

Methods
The proof-of-concept of the Pcond method was assessed on mechanical (lung simulator) and physiological (cadavers) bench models. Its diagnostic performance was evaluated in 213 patients, using the standard low-flow insufflation method as a reference. In 45 patients, the respiratory and hemodynamic tolerance of the Pcond method was compared with the standard low-flow method.

Measurements and main results
Bench assessments validated the Pcond method proof-of-concept. Sensitivity and specificity of the Pcond method for AOP detection were 93% and 91%, respectively. AOP obtained by Pcond and standard low-flow methods strongly correlated (r = 0.84, p < 0.001). Changes in SpO2 were significantly lower during Pcond than during standard method (p < 0.001).

Conclusion
Determination of Pcond during constant-flow assist control ventilation may permit to easily and safely detect and measure AOP.
Giant cell arteritis-related cerebrovascular ischemic events: a French retrospective study of 271 patients, systematic review of the literature and meta-analysis
Authors: Penet Thomas , Lambert Marc , Baillet Clio , Outteryck Olivier , Hénon Hilde , Morell-Dubois Sandrine , Hachulla Eric , Launay David , Pokeerbux Mohammad Ryadh 
Published: July 2023

Abstract
Background
Cerebrovascular ischemic events (CIE) are among the most severe complications of giant cell arteritis (GCA). Heterogeneity between different studies in the definition of GCA-related CIE leads to uncertainty regarding their real prevalence. The aim of our study was to evaluate the prevalence and describe the characteristics of GCA-related CIE in a well-phenotyped cohort completed by a meta-analysis of the existing literature.

Methods
In this retrospective study performed in the Lille University Hospital, all consecutive patients with GCA according to American College of Rheumatology (ACR) diagnostic criteria were included from January 1, 2010, to December 31, 2020. A systematic review of the literature using MEDLINE and EMBASE was performed. Cohort studies of unselected GCA patients reporting CIE were included in the meta-analysis. We calculated the pooled summary estimate of GCA-related CIE prevalence.

Results
A total of 271 GCA patients (89 males, mean age 72 ± 9 years) were included in the study. Among them, 14 (5.2%) presented with GCA-related CIE including 8 in the vertebrobasilar territory, 5 in the carotid territory, and 1 patient having multifocal ischemic and hemorrhagic strokes related to intra-cranial vasculitis. Fourteen studies were included in the meta-analysis, representing a total population of 3553 patients. The pooled prevalence of GCA-related CIE was 4% (95% CI 3–6, I2 = 68%).
Lower body mass index (BMI), vertebral artery thrombosis on Doppler US (17% vs 0.8%, p = 0.012), vertebral arteries involvement (50% vs 3.4%, p < 0.001) and intracranial arteries involvement (50% vs 1.8%, p < 0.001) on computed tomography angiography (CTA) and/or magnetic resonance angiography (MRA), and axillary arteries involvement on positron emission computed tomography (PET/CT) (55% vs 20%, p = 0.016) were more frequent in GCA patients with CIE in our population.

Conclusions
The pooled prevalence of GCA-related CIE was 4%. Our cohort identified an association between GCA-related CIE, lower BMI, and vertebral, intracranial, and axillary arteries involvement on various imaging modalities.
Fixed point theorems in graphical cone metric spaces and application to a system of initial value problems
Authors: Shukla Satish , Dubey Nikita , Shukla Rahul 
Published: July 2023

AbstractIn this paper, we introduce the notion of graphical cone metric spaces over Banach algebra and prove some fixed point results for a particular type of contractive mappings defined on such spaces. These results extend and generalize several results from metric, graphical metric, and cone metric spaces. Some examples that demonstrate the results proved herein are provided. An application of our results to the existence of solution of a pair of initial value problems is provided.
Normalized solutions for the discrete Schrödinger equations
Authors: Xie Qilin , Xiao Huafeng 
Published: July 2023

AbstractIn the present paper, we consider the existence of solutions with a prescribed $l^{2}$

l
2

-norm for the following discrete Schrödinger equations, $$ \textstyle\begin{cases} -\Delta ^{2} u_{k-1}-f(u_{k})= \lambda u_{k} \quad k\in \mathbb{Z}, \\ \sum_{k\in \mathbb{Z}} \vert u_{k} \vert ^{2}=\alpha ^{2}, \end{cases} $$

{

−

Δ
2

u

k
−
1

−
f
(

u
k

)
=
λ

u
k

k
∈
Z
,

∑

k
∈
Z

|

u
k

|
2

=

α
2

,

where $\Delta ^{2} u_{k-1}=u_{k+1}+u_{k-1}-2u_{k}$

Δ
2

u

k
−
1

=

u

k
+
1

+

u

k
−
1

−
2

u
k

, $f\in C(\mathbb{R}) $
f
∈
C
(
R
)
, α is a fixed constant, and $\lambda \in \mathbb{R}$
λ
∈
R
arises as a Lagrange multiplier. To get the solutions, we investigate the corresponding minimizing problem with the $l^{2}$

l
2

-norm constraint: $$ E_{\alpha}=\inf \biggl\{ \frac{1}{2}\sum \vert \Delta u_{k-1} \vert ^{2}-\sum F(u_{k}): \sum \vert u_{k} \vert ^{2}=\alpha ^{2} \biggr\} . $$

E
α

=
inf

{

1

2

∑
|
Δ

u

k
−
1

|
2

−
∑
F
(

u
k

)
:
∑
|

u
k

|
2

=

α
2

}

.
An elaborative analysis on a minimizing sequence with respect to $E_{\alpha}$

E
α

is obtained. We prove that there is a constant $\alpha _{0}\geq 0$

α
0

≥
0
such that there exists a global minimizer if $\alpha >\alpha _{0}$
α
>

α
0

, and there exists no global minimizer if $\alpha <\alpha _{0}$
α
<

α
0

. It seems that it is the first time to consider the solution with a prescribed $l^{2}$

l
2

-norm of the discrete Schrödinger equations.
Scattering threshold for a focusing inhomogeneous non-linear Schrödinger equation with inverse square potential
Authors: Boulaaras Salah , Ghanmi Radhia , Saanouni Tarek 
Published: July 2023

AbstractThis work studies the three space dimensional focusing inhomogeneous Schrödinger equation with inverse square potential $$ i\partial _{t} u-\biggl(-\Delta +\frac{\lambda}{ \vert x \vert ^{2}}\biggr)u + \vert x \vert ^{-2\tau} \vert u \vert ^{2(q-1)}u=0 , \qquad u(t,x):\mathbb{R}\times \mathbb{R}^{3}\to \mathbb{C}. $$
i

∂
t

u
−

(
−
Δ
+

λ

|
x

|
2

)

u
+
|
x

|

−
2
τ

|
u

|

2
(
q
−
1
)

u
=
0
,

u
(
t
,
x
)
:
R
×

R
3

→
C
.
The purpose is to investigate the energy scattering of global inter-critical solutions below the ground state threshold. The scattering is obtained by using the new approach of Dodson-Murphy, based on Tao’s scattering criteria and Morawetz estimates. This work naturally extends the recent paper by J. An et al. (Discrete Contin. Dyn. Syst., Ser. B 28(2): 1046–1067 2023). The threshold is expressed in terms the non-conserved potential energy. As a consequence, it can be given with a classical way with the conserved mass and energy. The inhomogeneous term $|x|^{-2\tau}$

|
x
|

−
2
τ

for $\tau >0$
τ
>
0
guarantees the existence of ground states for $\lambda \geq 0$
λ
≥
0
, contrarily to the homogeneous case $\tau =0$
τ
=
0
. Moreover, the decay of the inhomogeneous term enables to avoid any radial assumption on the datum. Since there is no dispersive estimate of $L^{1}\to L^{\infty}$

L
1

→

L
∞

for the free Schrödinger equation with inverse square potential for $\lambda <0$
λ
<
0
, one restricts this work to the case $\lambda \geq 0$
λ
≥
0
.