bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brane-jet stabilities from Janus and Sasaki-Einstein
Authors: Suh Minwoo 
Published: August 2023

Abstract
We show that there are certain perturbatively stable non-supersymmetric AdS vacua which are also brane-jet stable. Also we extend the analysis of brane-jets to the AdS vacua from curved domain walls like Janus solutions. First, we apply the brane-jet analysis to the non-supersymmetric Janus solutions of type IIB supergravity found by Bak, Gutperle and Hirano. Second, we study the brane-jet of AdS4 vacua from eleven-dimensional supergravity on Sasaki-Einstein manifolds: the supersymmetric and the skew-whiffed Freund-Rubin, the Pope-Warner, and the Englert solutions. Third, we examine the non-supersymmetric AdS4 vacua from Q1,1,1 and M1,1,1 manifolds discovered by Cassani, Koerber and Varela. It turns out that all the AdS vacua we consider in this work are brane-jet stable. Especially, the Janus, the skew-whipped Freund-Rubin, and the AdS4 vacua from Q1,1,1 and M1,1,1 are perturbatively stable within known subsectors of truncations and also brane-jet stable.
An Existence Result for a Fractional Critical (p, q)-Laplacian Problem with Discontinuous Nonlinearity
Authors: Ambrosio Vincenzo , Di Donato Daniela 
Published: August 2023

AbstractIn this paper, we establish the existence of a nonnegative nontrivial weak solution for a fractional critical (p, q)-Laplacian problem with discontinuous nonlinearity. The approach is based on suitable variational methods.
Quit bugging me: phorid fly parasitoids affect expression of an immune gene in foraging fire ant workers
Authors: King J. T. , Starkey J. , Holmes V. R. , Puckett R. T. , Vargo E. L. 
Published: August 2023

AbstractHost-parasitoid interactions are complex. A parasitoid can change its host’s behavior by direct infection or simply by its presence in the shared environment. In the red imported fire ant (RIFA,Solenopsis invicta), workers display defensive postures to avoid potential parasitism when fire ant decapitating flies (Pseudacteonspp.) hover above them. In addition to changes in the behavior of individual ants, RIFA colonies limit their foraging when decapitating flies are present. To further understand these interactions, we investigated the molecular basis of changes in foraging behavior at the colony level. By quantifying expression of theS. invicta foraginggene (Sifor),odorant binding protein 11, and immune genes of workers of unknown infection status in colonies exposed to decapitating flies and control colonies over a 48-h period, we aimed to provide information on the molecular processes related to change in foraging behavior of RIFA. We found upregulation of an immune gene,defensin-2, in colonies exposed to decapitating fly parasitoids. However, we did not detect significant differences in expression levels of three other genes related to immune function:abaecin, cytochrome P450 4C1-like, andhymenoptaecin.Although colonies exposed to parasitoids foraged less than control colonies (flies absent), they did not experience significant changes inSifor, a gene correlated with worker caste performance, orodorant binding protein 11, a gene upregulated in foragers. These results show that molecular processes associated with diminished foraging activity are set into place by the mere presence of the flies or by early stages of phorid fly infection.
Implicit signatures of voluntary action reduce with repeated motor practice
Authors: Dempsey-Jones Harriet , Majchrowicz Bartosz , Haggard Patrick 
Published: August 2023

AbstractThe sense of controlling one’s actions and their consequences is a critical aspect of successful motor activity. While motor performance typically improves with learning, it is unclear whether, how, and why higher order aspects of motor cognition are also affected. Here, we used an implicit measure of sense of agency—the ‘intentional binding’ effect—as participants learned to make a skilled action involving precise control of thumb adduction. These actions were predictably followed by a tone (the outcome). At pre-test, we showed the perceived time of the tone was shifted towards the thumb action, compared to a control condition in which tones occurred without actions. Next, a relevant training group learned to refine the direction of the thumb movement, while an irrelevant training group was trained on another movement. Manipulation checks demonstrated that, as expected, the relevant training group improved performance of the trained movement, while the irrelevant training group did not. Critically, while both groups still showed binding of the tone towards the thumb action at post-test, the relevant training group showed less binding than the irrelevant training group. Given the link between intentional binding and volitional control of action, we suggest our result demonstrates subjective agency over the outcome of a skilled action decreases as practice makes the skilled action more fluent. We suggest that this reduction in sense of agency over movement outcomes is consistent with the decreasing cognitive engagement, or automatization, that occurs during skill learning.
Development and validation of nomogram prognostic model for predicting OS in patients with diffuse large B-cell lymphoma: a cohort study in China
Authors: Li Xiaosheng , Xu Qianjie , Gao Cuie , Yang Zailin , Li Jieping , Sun Anlong , Wang Ying , Lei Haike 
Published: August 2023

AbstractThis study comprehensively incorporates pathological parameters and novel clinical prognostic factors from the international prognostic index (IPI) to develop a nomogram prognostic model for overall survival in patients with diffuse large B-cell lymphoma (DLBCL). The aim is to facilitate personalized treatment and management strategies. This study enrolled a total of 783 cases for analysis. LASSO regression and stepwise multivariate COX regression were employed to identify significant variables and build a nomogram model. The calibration curve, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA) curve were utilized to assess the model’s performance and effectiveness. Additionally, the time-dependent concordance index (C-index) and time-dependent area under the ROC curve (AUC) were computed to validate the model’s stability across different time points. The study utilized 8 selected clinical features as predictors to develop a nomogram model for predicting the overall survival of DLBCL patients. The model exhibited robust generalization ability with an AUC exceeding 0.7 at 1, 3, and 5 years. The calibration curve displayed evenly distributed points on both sides of the diagonal, and the slopes of the three calibration curves were close to 1 and statistically significant, indicating high prediction accuracy of the model. Furthermore, the model demonstrated valuable clinical significance and holds the potential for widespread adoption in clinical practice. The novel prognostic model developed for DLBCL patients incorporates readily accessible clinical parameters, resulting in significantly enhanced prediction accuracy and performance. Moreover, the study’s use of a continuous general cohort, as opposed to clinical trials, makes it more representative of the broader lymphoma patient population, thus increasing its applicability in routine clinical care.
The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases
Authors: Donners Ricardo , Tunariu Nina , Tovey Holly , Hall Emma , Chua Sue , Cook Gary , Du Yong , Blackledge Matthew D. , Parker Christopher C. , Koh Dow-Mu 
Published: August 2023

Abstract
Objectives
To investigate whether baseline 18F-sodium fluoride (NaF) and 18F-choline PET activity is associated with metastatic castration-resistant prostate cancer (mCRPC) global and individual bone metastases’ DWI MR imaging response to radium-223 treatment.

Methods
Thirty-six bone-only mCRPC patients were prospectively recruited from three centers. Whole-body (WB)-MRI with DWI and 18F-NaF and 18F-choline PET/CT were performed at therapy baseline and 8-week intervals. In each patient, bone disease median global (g)ADC change between baseline and follow-up was calculated. Additionally, up to five bone target lesions per patient were delineated and individual median ADC change recorded. An ADC increase > 30% defined response per-patient and per-lesion. For the same targets, baseline 18F-NaF and 18F-choline PET SUVmax were recorded. Mean SUVmax across patient targets was correlated with gADC change and lesion SUVmax with per-lesion ADC change.

Results
A total of 133 lesions in 36 patients (14 responders) were analyzed. 18F-NaF PET per-patient mean SUVmax was significantly higher in responders (median = 56.0 versus 38.7 in non-responders; p = 0.008), with positive correlation between SUVmax and gADC increase (rho = 0.42; p = 0.015). A 48.7 SUVmax threshold identified responders with 77% sensitivity and 75% specificity. Baseline 18F-NaF PET per-lesion SUVmax was higher in responding metastases (median = 51.6 versus 31.8 in non-responding metastases; p = 0.001), with positive correlation between baseline lesion SUVmax and ADC increase (rho = 0.39; p < 0.001). A 36.8 SUVmax threshold yielded 72% sensitivity and 63% specificity. No significant association was found between baseline 18F-choline PET SUVmax and ADC response on a per-patient (p = 0.164) or per-lesion basis (p = 0.921).

Conclusion
18F-NaF PET baseline SUVmax of target mCRPC bone disease showed significant association with response to radium-223 defined by ADC change.

Clinical relevance statement
18F-sodium fluoride PET/CT baseline maximum SUV of castration-resistant prostate cancer bone metastases could be used as a predictive biomarker for response to radium-223 therapy.

Key Points
• 18F-sodium fluoride PET baseline SUVmax of castration-resistant prostate cancer bone metastases showed significant association with response to radium-223.
• Baseline 18F-sodium fluoride PET can improve patient selection for radium-223 therapy.
• Change in whole-body DWI parameters can be used for response correlation with baseline 18F-sodium fluoride PET SUVmax in castration-resistant prostate cancer bone metastases.
MERCURY-3: a randomized comparison of netarsudil/latanoprost and bimatoprost/timolol in open-angle glaucoma and ocular hypertension
Authors: Stalmans Ingeborg , Lim Kin Sheng , Oddone Francesco , Fichtl Marek , Belda Jose I. , Hommer Anton , Laganovska Guna , Schweitzer Cédric , Voykov Bogomil , Zarnowski Tomasz , Holló Gábor 
Published: August 2023

Abstract
Purpose
To compare the efficacy and safety of the fixed-dose combination (FDC) of netarsudil 0.02%/latanoprost 0.005% ophthalmic solution (NET/LAT; Roclanda®) with bimatoprost 0.03%/timolol maleate 0.5% (BIM/TIM; Ganfort®) ophthalmic solution in the treatment of open-angle glaucoma (OAG) and ocular hypertension (OHT).

Methods
MERCURY-3 was a 6-month prospective, double–masked, randomized, multicenter, active-controlled, parallel-group, non-inferiority study. Patients (≥ 18 years) with a diagnosis of OAG or OHT in both eyes that was insufficiently controlled with topical medication (IOP ≥ 17 mmHg in ≥ 1 eye and < 28 mmHg in both eyes) were included. Following washout, patients were randomized to once-daily NET/LAT or BIM/TIM for up to 6 months; efficacy was assessed at Week 2, Week 4, and Month 3; safety was evaluated for 6 months. Comparison of NET/LAT relative to BIM/TIM for mean IOP at 08:00, 10:00, and 16:00 h was assessed at Week 2, Week 6, and Month 3. Non-inferiority of NET/LAT to BIM/TIM was defined as a difference of ≤ 1.5 mmHg at all nine time points through Month 3 and ≤ 1.0 mmHg at five or more of nine time points through Month 3.

Results
Overall, 430 patients were randomized (NET/LAT, n = 218; BIM/TIM, n = 212), and all received at least one dose of study medication. Efficacy analyses were performed at Month 3 on 388 patients (NET/LAT, n = 184; BIM/TIM, n = 204). NET/LAT demonstrated non-inferiority to BIM/TIM, with a between-treatment difference in IOP of ≤ 1.5 mmHg achieved at all time points and ≤ 1.0 mmHg at the majority of time points (six of nine) through Month 3. Mean diurnal IOP during the study ranged from 15.4 to 15.6 mmHg and 15.2 to 15.6 mmHg in the NET/LAT and BIM/TIM groups respectively, with no between-group statistically significant difference. No significant differences were observed in key secondary endpoints. No serious, treatment-related adverse events (AEs) were observed, and AEs were typically mild/moderate in severity. The most common treatment-related AEs were conjunctival hyperemia (NET/LAT, 30.7%; BIM/TIM, 9.0%) and cornea verticillata (NET/LAT, 11.0%; BIM/TIM, 0%).

Conclusions
Once-daily NET/LAT was non-inferior to BIM/TIM in IOP reduction in OAG and OHT, with AEs consistent with previous findings. NET/LAT offers a compelling alternative FDC treatment option for OAG and OHT.
Is happier music groovier? The influence of emotional characteristics of musical chord progressions on groove
Authors: Kawase Satoshi 
Published: August 2023

AbstractSpecific rhythmic patterns in music have been reported to induce an urge to move with feelings of pleasure or enjoyment, called “groove.” However, it is unclear how the emotional characteristics of music (e.g., happiness or sadness) affect groove. To address this issue I investigated the effects of the emotional characteristics of music on groove by altering the chord progressions accompanying drum breaks composed by a professional composer while manipulating independent tempo and rhythmic patterns. An online listening experiment was conducted using pieces composed by a professional composer but comprising different types of chord progressions that lead to happiness or sadness. Participants evaluated the nine items on a 7-point scale, including urge to move (i.e., groove), felt emotions, nori, and liking. The experiment found that: (1) chord progressions that evoke happiness were more likely to induce groove, (2) emotional characteristics did not interact with tempi and syncopation in terms of groove ratings, and (3) the accompaniment of drum breaks enhanced groove in both happy and sad chord progressions. Musical pieces with chord progressions that induce happiness were more likely to evoke groove, namely the urge to move. This implies that considering the emotional characteristics of musical pieces and rhythms is crucial when creating music for movement during rehabilitation, therapy, or dance.
The effect of cyclic loading on the fracture resistance of 3D-printed and CAD/CAM milled zirconia crowns—an in vitro study
Authors: Refaie Ashraf , Bourauel Christoph , Fouda Ahmed Mahmoud , Keilig Ludger , Singer Lamia 
Published: August 2023

Abstract
Objectives
The aim of this study was to evaluate the effect of cyclic mechanical loading on the fracture resistance of 3D-printed zirconia crowns in comparison to milled zirconia crowns.

Materials and methods
Monolithic zirconia crowns (n = 30) were manufactured using subtractive milling (group M) and 3D additive printing (group P). Nine samples of each group were fractured under one-time loading while the other 6 samples were subjected to cyclic loading for 1.2 million cycles before being subjected to one-time loading until fracture. Scanning electron microscope (SEM) fractographic analysis was carried out on fractured fragments of representative samples.

Results
The mean for fracture resistance of group M was 1890 N without cyclic loading and 1642 N after being subjected to cyclic loading, and they were significantly higher than that of group P (1658 N and 1224 N respectively).

Conclusions
The fabrication technique and cyclic loading affect the fracture resistance of zirconia crowns. Although the fracture resistance values for the 3D-printed crowns were lower than those of the milled, still they are higher than the masticatory forces and thus could be considered being clinically acceptable.

Clinical relevance
Concerning fracture resistance, 3D-printed crowns can withstand the masticatory forces for the long term without any cracks or failure.
Structural characterization of carboxyatractyloside and acaricidal activity of natural ent-kaurene diterpenoids isolated from Chamaeleon gummifer against Tetranychus urticae
Authors: Badalamenti Natale , Bruno Maurizio , Pavela Roman , Maggi Filippo , Benelli Giovanni 
Published: August 2023

AbstractPlant-borne secondary metabolites are attracting high interest for their potential use in agricultural applications, with special reference to the control of arthropod pests. In the present work, the structural elucidation of glycosylated diterpenoid carboxyatractyloside (2) isolated from the roots of Chamaeleon gummifer Cass. (Asteraceae) is reported by means of spectroscopic and spectrometric techniques. Complete identification occurred thanks to one- and two-dimensional NMR experiments, assigning the single protons and carbons, and the stereochemistry by the NOESY correlations. Carboxyatractyloside (2), together with two ent-kaurenes atractyloside (1) and atractyligenin (3), extracted from the roots of C. gummifer, have been tested for their acaricidal and oviposition inhibition activity against the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae) Notably, compounds 1–3 were toxic to T. urticae, leading to significant mortality, oviposition inhibition, reduced hatchability of eggs, and natality inhibition. However, at the lowest dose (12.5 µg cm−2) compound 2 was the most effective, leading to mortality > 60% after 5 days exposure, inhibiting oviposition by > 70% and egg hatching by 33%; it also reduced natality by 80%. Overall, these compounds represent valuable candidates to develop novel acaricides for crop protection. Further research on how to develop stable formulations for field use, as well as on non-target effects of these compounds on pollinators and mite biocontrol agents, is ongoing.
Die Abwägung von Kunstfreiheit und Tierschutz
Authors: Korn Lukas Paul 
Published: August 2023

ZusammenfassungWerden lebendige Tiere im Rahmen künstlerischer Darbietungen verwendet und ihnen dabei Schmerzen,
Leiden oder Schäden zugefügt, kann dies einen Verstoß gegen das Tierschutzgesetz (TierSchG)
begründen und Untersagungsverfügungen, Bußgelder oder Strafverfahren nach sich ziehen. In
derartigen Fällen kommt es entscheidend darauf an, ob die Ausübung der grundrechtlich gewährleisteten
Kunstfreiheit einen ,,vernünftigen Grund‘‘ i.S.d. TierSchG darstellt. Die Ausfüllung dieses
unbestimmten Rechtsbegriffs erfordert eine Abwägung zwischen den Verfassungsgütern der Kunstfreiheit
aus Art. 5 Abs. 3 S. 1 Var. 1 GG und dem Staatsziel Tierschutz aus Art. 20a GG. Der vorliegende Beitrag
zeigt auf, in welchen Fällen eine solche Abwägungsentscheidung notwendig ist und entwickelt Kriterien
für den Abwägungsvorgang.
Die tatsächlichen und rechtlichen Hintergründe der Kormoranverordnungen der Länder
Authors: Gerhold Sönke Florian , Mittag Vincent 
Published: August 2023

ZusammenfassungDer Kormoran ist derzeit in den meisten Flächenstaaten Deutschlands nach den Vorgaben sogenannter
Kormoranverordnungen jagdbar in einem weiten Sinne, obwohl er dem Tötungsverbot der Vogelschutzrichtlinie
(RL 2009/147/EG) unterfällt. Die Verordnungen sehen insofern Ausnahmen vom generellen Tötungsverbot
des BNatSchG insbesondere aus Gründen des Schutzes von Fischfauna und Fischereiwirtschaft vor. Der
vorliegende Beitrag nimmt die tatsächlichen und rechtlichen Hintergründe der Kormoranverordnungen
in den Blick und setzt sich dabei auch mit der praktisch sehr bedeutsamen Frage nach dem Verhältnis
des TierSchG zum BNatSchG auseinander.
Rethinking how children individuate objects: spatial indexicals in early development
Authors: Hildebrandt Frauke , Glauer Ramiro , Moore Richard 
Published: August 2023

AbstractThe current understanding of cognitive development rests on the premise that infants can individuate objects early on. However, the so-called object-first account faces severe difficulties explaining extant empirical findings in object individuation tasks while alternative, more parsimonious explanations are available. In this paper, we assume that children start as feature-thinkers without being able to individuate objects and show how this ability can be learned by thinkers who do not already implicitly possess the notion of an object. Based on Tugendhat's ideas on the relation between singular terms and object reference, we argue that spatial indexicals comprise the fundamental means of object individuation and describe how feature thinkers might acquire the complex substitutional system of spatial indexicals. In closing, two accounts of object cognition that do not rely on symbolic capacities, namely Pylyshyn's FINST indexes and Burge's perceptual objectivity, are critically discussed.
Language-Concordant Care: a Qualitative Study Examining Implementation of Physician Non-English Language Proficiency Assessment
Authors: Garcia Maria Esteli , Williams Mia , Mutha Sunita , Diamond Lisa C. , Jih Jane , Handley Margaret A. , Pathak Sarita , Karliner Leah S. 
Published: August 2023

Abstract
Background
Language concordance can increase access to care for patients with language barriers and improve patient health outcomes. However, systematically assessing and tracking physician non-English language skills remains uncommon in most health systems. This is a missed opportunity for health systems to maximize language-concordant care.

Objective
To determine barriers and facilitators to participation in non-English language proficiency assessment among primary care physicians.

Design
Qualitative, semi-structured interviews.

Participants
Eleven fully and partially bilingual primary care physicians from a large academic health system with a language certification program (using a clinician oral proficiency interview).

Approach
Interviews aimed to identify barriers and facilitators to participation in non-English language assessment. Two researchers independently and iteratively coded transcripts using a thematic analysis approach with constant comparison to identify themes.

Key Results
Most participants were women (N= 9; 82%). Participants reported proficiency in Cantonese, Mandarin, Russian, and Spanish. All fully bilingual participants (n=5) had passed the language assessment; of the partially bilingual participants (n=6), four did not test, one passed with marginal proficiency, and one did not pass. Three themes emerged as barriers to assessment participation: (1) beliefs about the negative consequences (emotional and material) of not passing the test, (2) time constraints and competing demands, and (3) challenging test format and structure. Four themes emerged as facilitators to increase assessment adoption: (1) messaging consistent with professional ethos, (2) organizational culture that incentivizes certification, (3) personal empowerment about language proficiency, and (4) individuals championing certification.

Conclusions
To increase language assessment participation and thus ensure quality language-concordant care, health systems must address the identified barriers physicians experience and leverage potential facilitators. Findings can inform health system interventions to standardize the requirements and process, increase transparency, provide resources for preparation and remediation, utilize messaging focused on patient care quality and safety, and incentivize participation.