bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on transient photocurrent induced by energy level defect of schottky diode irradiated by high power pulsed laser
Authors: Wang Y. H. , Ma Y. Q. , Wang T. W. , Lei Z. Y. , Chen Z. J. , Shangguan S. P. , Han J. W. 
Published: February 2023

Abstract
The transient photocurrent is one of the key parameters of the spatial radiation effect of photoelectric devices, and the energy level defect affects the transient photocurrent. In this paper, by studying the deep level transient spectrum of a self-designed Schottky diode, the defect properties of the interface region of the anode metal AlCu and Si caused by high-temperature annealing at 150 ℃, 200 ℃ and 300 ℃ for 1200 h have been quantitatively analyzed. The study shows that the defect is located at the position of + 0.41 eV on the valence band, the concentration is 2.8×1013/cm2, and the capture cross section is σ = 8.5×1017. The impurity energy level mainly comes from the diffusion of Al atom in anode metal. We found that the defect did not cause the electrical performance degradation and obvious morphology change of the device, but the transient photocurrent increased significantly. The reason is that the high temperature treatment results in a growth in the density of states at the interface between AlCu-Si. The more mismatched dislocations and recombination center increased the reverse current of the heterojunction. The above view is proved by the TCAD simulation test.
Alluvial coastal aquifers in the Gulf Extensional Province under the influence of extreme weather events: the case of San Felipe-Punta Estrella aquifer, BC Mexico
Authors: Ramírez-Hernández Jorge , Martín-Loeches Miguel , Carreón-Diazconti Concepción , Reyes-López Jaime , Rodríguez-Burgueño Jesús Eliana , Salas-Contreras Pedro 
Published: February 2023

Abstract
Groundwater in semiarid regions is frequently the only water source. In addition, coastal cities worldwide, such as the city of San Felipe, have significant hydric pressure growth due to tourism and migration. In this work, a gravity survey allowed to delineate the geometry of the San Felipe-Punta Estrella aquifer basement identifying an uplift of the metamorphic and granitic basement according to the regional extensional tectonic model at approximately 400 m below the surface. Furthermore, groundwater geochemistry and isotopic composition interpreted in conjunction with the aquifer geometry allowed for pointing out at least three hydrological implications. First, the granitic uplift reduces the overall volume of the groundwater reservoir, with no apparent reduction in water availability. However, the uplift acts as a deep flow barrier that induces vertical upflows, modifying regional flows. Second, the high fluoride concentration in groundwater can be related to the dissolution of fluoride-bearing minerals, fluoride mobilization at high Na/Ca ratios and high pH, and active regional thermal systems. The third finding was determining the source of groundwater recharge from groundwater stable isotope signature, which is the moisture surges from hurricanes in the eastern Pacific Ocean. These structural and hydrogeological issues have crucial implications for water quality and availability in semiarid regions with high hydric pressure to promote a sustainable water extraction policy.
Efficacy and safety of primary tailored phacoemulsification combined with goniosynechialysis for refractory acute primary angle closure
Authors: Wu Xinna , Liu Xiaobao , Xiao Suzhen , Cai Yajing , Yu Mengting , Xu Bingqiang , Wang Yanling , Wu Wenjie 
Published: February 2023

Abstract
Purpose: To assess the safety, efficacy, and long-term clinical outcomes of primary tailored phacoemulsification (phaco) combined with goniosynechialysis (GSL; phaco-GSL) in refractory acute primary angle closure (APAC) eyes with uncontrolled high intraocular pressure (IOP).
Methods: This retrospective case series comprised 51 eyes of 42 consecutive patients with refractory APAC and high IOP who were treated using primary tailored phaco-GSL at 3 hospitals in China, from 2014 to 2021. Preoperative and postoperative IOP, corrected distant visual acuity (CDVA), corneal endothelial cell density (CECD), intraoperative and postoperative complications were recorded. The safety, efficacy and subsequent long-term clinical outcomes were analyzed.
Results: The mean CDVA (LogMAR) was improved from 1.67±0.94 preoperatively to 0.23±0.26 postoperatively (P <0.001). Preoperative CECD was 2309.39±541.03 cells/mm2 in 33 eyes and inaccessible in 18 eyes due to severe corneal edema; at the final follow-up, the mean CECD of all patients was 1823.50±533.40 cells/mm2 (P <0.001). The mean IOP decreased from 48.51±6.25 mmHg preoperatively to 15.66±2.27 mmHg at the final follow-up (P <0.001). Among 51 eyes, additional tailored procedures performed were corneal indentation in 42 eyes, epithelial debridement in 9 eyes, giant epithelial bullae view in 4 eyes, pars-plana fluid aspiration in 3 eyes, and secondary intraocular lens implantation in 7 eyes. The IOP of all eyes was well controlled eventually and 47 eyes (92.16%) were successfully treated by phaco-GSL alone. No significant intraoperative or postoperative complications were observed.
Conclusions: Primary tailored phaco-GSL is a safe and effective surgical management strategy for patients with refractory APAC and high IOP.
Multivariate analysis of groundwater around Solous lll dumpsite, Lagos, South-West Nigeria
Authors: Aduojo Ameloko Anthony , Mosobalaje Olatunde Olu. , Uchegbulam Okezie , Johnson Allo Olawale , Ifeanyi Obihan 
Published: February 2023

Abstract
The study of changes in groundwater quality across different areas is necessary so as to track the sources of the contamination in the water sources. Assessment of the physiochemical parameters of groundwater samples obtained from both borehole and hand-dug wells were conducted around the Solous III dumpsite, Lagos, South-western, Nigeria. Multivariate statistics such as correlation coefficient analysis, Hierarchical cluster analysis (HCA) and principal component analyses (PCA) were utilised to assess the mode of association of parameters and their interrelationships to establish possible sources of groundwater contamination. Eight groundwater samples were obtained around the dumpsite during the wet and dry seasons for analysis of their physicochemical properties. The results of the analyses of water samples indicated seasonal changes for the various elemental constituents analysed. There was generally an increase in mean concentration of total dissolved solid (TDS), pH, temperature and hardness in the dry season study, and a corresponding increase in the mean concentration of Ca2+, Mg2+, Na+, SO42-, NO32-, Pb, and Cr, when compared with the wet season. On the other hand, there was reduction in the mean concentration of electrical conductivity (EC), K+, Cl-, PO43-, Fe, Zn, Mn, Cu, and Ni in the dry season when compared with the wet season. Some of the water sample parameters exhibited high concentration when compared with WHO/SON standard, which may be due to the impact of leachate migration from the dumpsite. Five varimax rotated factor loadings and communalities were responsible for 30 % and 35 % of the total variance in the data set during wet and dry seasons respectively. The PCA parameters identified to be influencing the quality of water are perhaps related to anthropogenic activities from the dumpsite, soluble mineral dissolution, rock–groundwater interaction and weathering activities while PCA performed on samples of groundwater during wet and dry seasons indicated 2 and 3 important clusters, respectively. The clusters of parameters as observed in the parameters dendrograms clearly validates the results earlier obtained in the correlation analysis component of this research. The dendrogram was also able to reflect variation in the quality of water with season as indicated in the difference in the number of clusters during both wet and dry seasons.
FAK loss reduces BRAFV600E-induced ERK phosphorylation to promote intestinal stemness and cecal tumor formation
Authors: Gao Chenxi , Ge Huaibin , Kuan Shih-Fan , Cai Chunhui , Lu Xinghua , Esni Farzad , Schoen Robert , Wang Jing , Chu Edward , Hu Jing 
Published: February 2023

Abstract

BRAFV600E mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAFV600E drives tumorigenesis through constitutive downstream extracellular signal-regulated kinase (ERK) activation, but high-intensity ERK activation can also trigger tumor suppression. Whether and how oncogenic ERK signaling can be intrinsically adjusted to a “just-right” level optimal for tumorigenesis remains undetermined. In this study, we found that FAK (Focal adhesion kinase) expression was reduced in BRAFV600E-mutant adenomas/polyps in mice and patients. In Vill-Cre;BRAFV600E/+;Fakfl/fl mice, Fak deletion maximized BRAFV600E’s oncogenic activity and increased cecal tumor incidence to 100%. Mechanistically, our results showed that Fak loss, without jeopardizing BRAFV600E-induced ERK pathway transcriptional output, reduced EGFR (epidermal growth factor receptor)-dependent ERK phosphorylation. Reduction in ERK phosphorylation resulted in increased mRNA expression and stability of Lgr4, promoting intestinal stemness and cecal tumor formation. Together, our findings show that a “just-right” ERK signaling optimal for BRAFV600E-induced cecal tumor formation can be achieved via Fak loss-mediated downregulation of ERK phosphorylation.
Classification of Breast Cancer in Mammograms Using an Optimized Hybrid Deep Learning Models and Feature Fusion Techniques
Authors: shanker mc 
Published: February 2023

Abstract
Breast cancer is the most common deadly disease occurred in women. The major cause of the breast cancer agent is still not known. The early detection and treatment of breast cancer prevent the spreading of cancers to other parts and increase the lifetime of patients. Micro-calcification is one of the main signs of breast cancer. Mammography is a widely used digital screening approach to detect a microcalcification cluster in images. Compared to other image modalities, mammography is inexpensive and requires a low radiation dose. Image processing techniques with the aid of machine learning (ML) and deep learning (DL) techniques support radiologists to diagnose breast cancers earlier. In this work, the modified hybrid models with optimized feature selection models are proposed for accurate microcalcification classifications. The hybrid models of ResNet101V2 with Long short-term memory (LSTM) layers and ResNet101V2 with Support Vector Machine (SVM) classifiers are proposed for feature extraction. Then, the features are combined using serial-based feature fusion techniques. The performance of classifier models and feature selection process is improved using the metaheuristic algorithm of the Cheetahs optimizer. Experimental results on the MIAS breast cancer database show the superior performance of proposed models in terms of area under the curve (AUC), accuracy, and specificity and recall rates.
Predictive heuristic control: Inferring risks from heterogeneous nowcast accuracy
Authors: van der Werf Job Augustijn , Kapelan Zoran , Langeveld Jeroen Gerardus 
Published: February 2023

AbstractUrban Drainage Systems can cause ecological and public health issues by releasing untreated contaminated water into the environment. Real-time control (RTC), augmented with rainfall nowcast, can effectively reduce these pollution loads. This research aims to identify key dynamics in the nowcast accuracies and relate those to the performance of nowcast-informed rule-based (RB)-RTC procedures. The developed procedures are tested in the case study of Rotterdam, the Netherlands. Using perfect nowcast data, all developed procedures showed a reduction in combined sewer overflow volumes of up to 14.6%. Considering real nowcast data, it showed a strong ability to predict if no more rain was expected, whilst performing poorly in quantifying rainfall depths. No relation was found in the nowcast accuracy and the consistency of the predicted rainfall using a moving horizon. Using the real nowcast data, all procedures, with the exception of the one predicting the end of the rainfall event, showed a significant risk of operative deterioration (performing worse than the baseline RB-RTC), linked to the relative performance of the nowcast algorithm. Understanding the strengths of a nowcast algorithm can ensure the reliability of the RB-RTC procedure and can negate the need for detailed modelling studies by inferring risks from nowcast data.
Постковидное цветовосприятие: влияние COVID-19 на выбор цветонаименования
Authors: Грибер Юлия А. , Парамей Галина В. 
Published: February 2023

Введение. В последнее время появляется всё больше данных о том, что у перенесших COVID-19 наблюдаются различные симптомы нарушения работы зрительной системы. Мы предположили, что у них также может меняться цветовосприятие, вызывая изменения паттерна называния цветов. Чтобы проверить эту гипотезу, мы сравнили цветонаименование людей, выздоровевших после COVID-19 (N = 201, 54 мужчины и 147 женщин в возрасте от 19 до 65 лет, M = 33,4, SD = 13,2), и тех, чьи ответы были получены до пандемии (далее – здоровая контрольная группа) (N = 2457, 1052 мужчины и 1402 женщины в возрасте 16–98 лет, M = 41,36, SD = 17,7). Методы. Данные собирались в ходе онлайн-эксперимента (http://colournaming.com). Участникам в случайном порядке предъявлялись виртуальные цветовые карточки, отобранные компьютерной программой из 606 стимулов, и предлагалось назвать каждый цвет, используя наиболее подходящий цветовой дескриптор (метод свободного называния цветов). Результаты. Исследование показало, что, по сравнению со здоровой контрольной группой, участники, переболевшие COVID-19, действительно используют измененную модель называния цвета: у них заметно увеличивается частота «коричневых», «зеленых» и «серых» цветонаименований, а также отмечается более частое использование ахроматических модификаторов «грязный», «бледный», «тусклый» и «пастельный». Обсуждение результатов. Эти различия указывают на общее «потемнение» и снижение насыщенности воспринимаемых цветов. Изменение модели цветонаименования является косвенным доказательством влияния коронавируса на цветовое зрение. А именно: относительно высокая частота цветонаименований «коричневый» и «серый» может отражать ускоренное старение хрусталика, а феномен «потемнения» и снижения насыщенности может свидетельствовать о нарушении обработки пространственного контраста яркости. Эти предположения в настоящее время проверяются авторами экспериментально с применением тестовой диагностики цветового зрения у лиц, перенесших COVID-19.
Мотивация к успеху учащихся в малых группах при обучении музыке
Authors: Макарова Елена А. , Макарова Елена Л. , Денисов Борис В. 
Published: February 2023

Введение. Научная новизна исследования состоит в описании феноменологии малых групп, под которой понимается описание основных явлений, возникающих в сфере взаимоотношений и характерных для малых групп, психологических особенностей формирования мотивации успеха, а также сравнительный анализ результатов анкетирования по формированию мотивации у российских и китайских учащихся. Методы. Анкетирование проводилось с помощью методики, составленной для оценки мотивации к успеху у учащихся малых групп. Адаптированная анкета состоит из вопросов методики социально-психологического исследования малых групп А. В. Сидоренкова и из вопросов зарубежных опросников, посвященных исследованию социальной лености в малой группе. Респондентами были китайские и российские студенты, что позволило провести сравнительный анализ. Целью исследования было получение двух массивов экспериментальных данных по исследуемым показателям, на основании которых был проведен анализ различий между ними. Статистический анализ данных включал вычисление средних величин показателей, а также оценку статистической значимости выявленных различий. Результаты. Проведено комплексное экспериментально-диагностическое исследование по формированию мотивационного процесса учащихся при работе в малых группах в процессе обучения музыке. Результаты исследования выявили социально-психологические противоречия, однако было также доказано, что все три группы респондентов имеют позитивные отношения внутри группы, нуждаются в социальной поддержке. Вторая часть эмпирического исследования оценивала уровень социальной лености при групповом участии в музыкальных занятиях и показала относительно низкий уровень социальной лености в малых группах среди китайских учащихся, более высокий – у российских студентов. Обсуждение результатов. В результате проведенного исследования представлен сравнительный анализ психологической диагностики сформированности мотивации к успеху учащихся при работе в малых группах в процессе обучения музыке в Шэньчжэньском колледже международного образования (Китай), Ростовской государственной консерватории им. С. В. Рахманинова и Таганрогском музыкальном колледже (Россия).
Type 2 Diabetes and HDL Dysfunction: A Key Contributor to
Glycemic Control
Authors: Rotllan Noemi , Julve Josep , Escolà-Gil Joan Carles 
Published: February 2023

Abstract:
High-density lipoproteins (HDL) have been shown to exert multiple cardioprotective
and antidiabetic functions, such as their ability to promote cellular cholesterol efflux
and their antioxidant, anti-inflammatory, and antiapoptotic properties. Type 2 diabetes
(T2D) is usually associated with low high-density lipoprotein cholesterol (HDL-C)
levels as well as with significant alterations in the HDL composition, thereby impairing its
main functions. HDL dysfunction also negatively impacts both pancreatic β-cell function
and skeletal muscle insulin sensitivity, perpetuating this adverse self-feeding cycle. The
impairment of these pathways is partly dependent on cellular ATP-binding cassette transporter
(ABC) A1-mediated efflux to lipid-poor apolipoprotein (apo) A-I in the extracellular
space. In line with these findings, experimental interventions aimed at improving HDL
functions, such as infusions of synthetic HDL or lipid-poor apoA-I, significantly improved
glycemic control in T2D patients and experimental models of the disease. Cholesteryl
ester transfer protein (CETP) inhibitors are specific drugs designed to increase HDLC
and HDL functions. Posthoc analyses of large clinical trials with CETP inhibitors have
demonstrated their potential anti-diabetic properties. Research on HDL functionality and
HDL-based therapies could be a crucial step toward improved glycemic control in T2D
subjects.
A Review on the Synthesis and Anticancer Potentials of Imidazothiazole
Derivatives
Authors: Kamboj Payal , Mahore Anjali , Husain Asif , Shaquiquzzaman Mohammad , Alam M. Mumtaz , Amir Mohammad 
Published: February 2023

Abstract:
Cancer is one of the severe diseases in which abnormal cells divide and proliferate in an
uncontrolled manner without any regulation. Globally cancer is among the leading causes of death;
according to a recent report of by the WHO, around 10 million people died in 2018 due to cancer. It
has also been reported that by 2040, approximately 30 million new cases will be reported every year.
The increase in the incidences of cancer is taking a toll on the health care system worldwide.
Considerable scientific literature is available on anticancer agents but newer therapeutic strategies are
still required in this field to address novel approaches to drug design and discovery to counter this
problem. Imidazothiazole represents a privileged scaffold in medicinal chemistry and provides the
medicinal chemist the possibility to modulate the physiochemical properties of the lead compound. In
recent times, imidazothiazole scaffold is broadly explored for its anticancer activity, which acts
through various mechanisms such as EGFR, B-RAF, DHFR kinase inhibition and tubulin polymerization
inhibition and other molecular mechanisms of action. Due to their feasible synthetic accessibility
and promising pharmacological profile, it has attracted various medicinal chemists to explore and develop
imidazothiazole derivatives as potent and safe anticancer agents. In the present article, we have
reviewed various potent imidazothiazole scaffold-based derivatives reported as anticancer agents,
their synthetic strategies, Structure Activity Relationship (SAR), mechanism of action, and molecular
docking along with their future perspective. This review will be very useful for medicinal chemists for
drug design and development of imidazothiazole-based potent antiproliferative agents.
Micro-fragmented Fat Inhibits the Progression of Human Mesothelioma
Xenografts in Mice
Authors: La Monica Silvia , Coccé Valentina , Bonelli Mara , Alessandri Giulio , Alfieri Roberta , Lagrasta Costanza Annamaria , Frati Caterina , Flammini Lisa , Gianni Aldo , Petrella Francesco , Paino Francesca , Pessina Augusto 
Published: February 2023

Background:
Malignant pleural mesothelioma is a pathology with no effective therapy and
a poor prognosis. Our previous study demonstrated an in vitro inhibitory effect on mesothelioma cell
lines of both the lysate and secretome of adipose tissue-derived Mesenchymal Stromal Cells. The inhibitory
activity on tumor growth has been demonstrated also in vivo: five million Mesenchymal Stromal
Cells, injected “in situ”, produced a significant therapeutic efficacy against MSTO-211H xenograft
equivalent to that observed after the systemic administration of paclitaxel.

Objective:
The objective of this study is to evaluate the efficacy of low amount (half a million) Mesenchymal
Stromal Cells and micro-fragmented adipose tissues (the biological tissue from which the Mesenchymal
Stromal Cells were isolated) on mesothelioma cells growth.

Methods:
Tumor cells growth inhibition was evaluated in vitro and in a xenograft model of mesothelioma.

Results:
The inhibitory effect of micro-fragmented fat from adipose-tissue has been firstly confirmed
in vitro on MSTO-211H cell growth. Then the efficacy against the growth of mesothelioma xenografts
in mice of both micro-fragmented fat and low amount of Mesenchymal Stromal Cells has been evaluated.
Our results confirmed that both Mesenchymal Stromal Cells and micro-fragmented fat, injected
“in situ”, did not stimulate mesothelioma cell growth. By contrast, micro-fragmented fat produced a
significant inhibition of tumor growth and progression, comparable to that observed by the treatment
with paclitaxel. Low amount of Mesenchymal Stromal Cells exerted only a little anticancer activity.

Conclusion:
Micro-fragmented fat inhibited mesothelioma cell proliferation in vitro and exerted a significant
control of the mesothelioma xenograft growth in vivo.