bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired Kidney Function Portended a Bleak Prognosis for Surgically Treated Hypertensive Intracerebral Hemorrhage Patients
Authors: Wang Jian , Wang Rui , Qin Hu , Zuo Lei 
Published: September 2023

Abstract

Purpose:
Spontaneous intracerebral hemorrhage (ICH) cases caused by hypertension often have poor prognoses. The use of dehydrant agents, such as mannitol, is common to reduce intracranial pressure and alleviate cerebral edema, but they may also pose a risk of worsening kidney function. This study aimed to investigate the impact of impaired kidney function on the outcomes of surgically treated hypertensive ICH patients.

Methods:
We conducted a retrospective analysis of a consecutive cohort of patients who underwent surgical intervention due to hypertension-related ICH at our institute between December 1, 2017, and January 31, 2022. Demographic, clinical, radiological, and prognostic data were collected. Patients were categorized into two groups based on 90-day mortality: group A [overall survival (OS) ≤3 months] and group B (OS >3 months). Survival analysis was performed to identify factors associated with poor outcomes.

Results:
Among the 232 eligible patients, group A exhibited significantly impaired kidney function, as indicated by mean estimated glomerular filtration rate (eGFR) at admission, postoperative, 3-day postoperative, and 7-day postoperative time points (91.9, 82.5, 73.5, 75.2 ml/min/1.73 m²). In contrast, group B did not show significant changes in kidney function (mean eGFR for the corresponding time points: 108.1, 106.5, 111.5, 109.6 ml/min/1.73 m²). The 3-day postoperative eGFR showed the strongest predictive ability for assessing prognosis [areas under the curve (AUC): 0.617, 0.675, 0.737, 0.730]. Univariate and multivariate analyses identified low Glasgow Coma Scale (GCS) score (3–8), ventricle intrusion of hematomas, cardiac failure, larger hematoma volume, infection, and lower 3-day postoperative eGFR as adverse factors for survival.

Conclusions:
Preserving kidney function is crucial for achieving favorable outcomes in hypertensive ICH cases. Impaired 3-day postoperative eGFR emerged as an independent risk factor for overall survival. Patients with cardiac failure, infection, and larger hematoma volume should receive careful management to improve outcomes.
Translation and Validation of ID-Migraine Questionnaire to North-Indian Vernacular Languages
Authors: Sahu Prachi , Chaturvedi Pragya , Khan Rahul , Singla Monika , Munshi Anjana , Singh Gagandeep 
Published: September 2023

AbstractBackground:ID-Migraine is an established screening tool for migraine. Translation and validation in more languages can increase its reach and scope.Aim:To translate and validate ID-Migraine for screening migraine patients in two North-Indian vernacular languages, that is, Hindi and Punjabi.Methods:ID Migraine was translated into Hindi and Punjabi. Subjects with headaches in outpatient clinics were administered the questionnaire according to their preferred language of choice and referenced clinical evaluations, performed by an experienced neurologist, based on current the ICHD-3 diagnostic criteria.Results:One hundred subjects with complaints of headaches and 60 healthy controls were recruited after informed consent. Of the 100 subjects with headaches, 73 (73%) screened positive with a translated version of ID-Migraine, and 60 (60%) were eventually diagnosed with migraine without aura. The sensitivity of the Hindi version of ID-Migraine was 94% (95% confidence intervals, 79% to 99%); specificity, 56% (95% CI, 31% to 78%); positive predictive value, 79% (95% CI, 69% to 86%) and negative predictive value, 83% (95% CI, 55% to 95%). The Punjabi version demonstrated a sensitivity of 86% (95% CI, 68% to 96%); specificity, 43% (95% CI, 23% to 66%); PPV, 68% (95% CI, 58% to 76%); and NPV, 69% (95% CI, 44% to 86%).Conclusion:The translated versions of ID-Migraine demonstrated high sensitivity and fair specificity for screening migraine in Indian subjects who speak and understand Hindi and Punjabi.
The Interface between Depression and Alzheimer’s Disease. A Comprehensive Approach
Authors: Modrego Pedro J. , Cerio Leyre D. de , Lobo Antonio 
Published: September 2023

Abstract
Depression and Alzheimer’s disease (AD) are frequent interacting diseases in the elderly with a negative impact on the quality of life of patients and caregivers. Late-life depression may be regarded either as an early symptom of AD or a risk factor for AD, depending on the context. This review was focused on the latest developments in the fields of the neurobiological basis and treatment of depression in AD. We found that some plausible hypotheses are emerging to correlate with depression in AD, such as neuroinflammation and dysimmune regulation. It seems that depression is not related to amyloid deposition, but this issue is not completely resolved. The response to antidepressants is controversial according to the evidence from 10 small double-blind randomized placebo-controlled clinical trials with antidepressants in AD patients with depression: four with sertraline, one with three arms (sertraline, mirtazapine, placebo), one with fluoxetine, one with imipramine, one with clomipramine, one with escitalopram, and one with vortioxetine. The total number of treated patients completing the trials was 638. The main criterion of a positive response was a reduction in the scores of clinical scales for depression of at least 50%. The weighted OR (odds ratio) was calculated with the method of Mantel-Haenszel: 1.29; 95% CI: 0.77–2.16. No significant differences were found compared with placebo. Antidepressants did not have a meaningful negative influence on cognition, which was measured with the mini-mental state examination (MMSE) in 18 clinical trials. Alternatives other than drugs are also discussed. Although there have been important advances in this field, pathophysiology and treatment deserve further research.
Day Case Knee Osteotomy
Authors: Kocialkowski Cezary , Hart Sam ,   Bristol Knee Group*, Murray James R. D. 
Published: September 2023

Introduction:
Knee osteotomy, both high tibial osteotomy (HTO) and distal femoral osteotomy (DFO), is a well-recognized treatment for young, active patients with unicompartmental knee osteoarthritis. Osteotomy around the knee is usually performed as an inpatient procedure. The aim of this study was to assess the effectiveness and patient satisfaction of our day-case protocol for knee osteotomy.

Methods:
All patients who underwent day-case knee osteotomy at the study unit, over a 3-year period, were reviewed to assess the success of ambulatory care for knee osteotomy. Patients were sent questionnaires to assess functional outcome and patient satisfaction with our day-case process.

Results:
Thirty-three knee osteotomies were performed as a day-case protocol, of which same-day discharge was achieved in 24 patients (73%) and discharge within 24 h achieved in 32 patients (97%). The mean postoperative Knee Osteoarthritis Outcome Score was 67.1% and 79% of patients rated their care as good or excellent. Return to sporting activities was achieved in 75% of patients, and 88% of the patients reported they would be happy to undergo day-case knee osteotomy again.

Conclusions:
Knee osteotomy, both HTO and DFO, can be performed as a day-case procedure with similar improvements in functional outcomes and no increased complication rate, compared to in-patient osteotomy.
Outcomes of Patients Undergoing Total Knee Arthroplasty with Spinal Anesthesia: A Comparison of Mepivacaine versus Bupivacaine
Authors: Holbert Samuel Elliott , Brennan Jane , Bahethi Shreeya , Mandich Madilyn , Cheema Minahil , Turcotte Justin J. , Macdonald James , King Paul 
Published: September 2023

Introduction:
Previous literature indicates that mepivacaine used for spinal anesthesia may lead to reduced recovery time and urinary retention compared to bupivacaine in patients undergoing total knee arthroplasty (TKA). We sought to compare outcomes between spinal anesthetics in our high-volume joint institution.

Materials and Methods:
A retrospective review of 553 unilateral primary TKA patients who received spinal anesthesia was conducted. Patients were divided by their receipt of mepivacaine or bupivacaine. Univariate comparisons before and after propensity score matching were used to compare outcomes for TKA patients receiving mepivacaine with those who did not.

Results:
Of the 553 patients, 102 received mepivacaine, and 451 received bupivacaine. After propensity score matching, patients who received bupivacaine experienced longer lengths of stay, received more oral morphine milligram equivalents (OMMEs), and were less likely to be discharged home. No differences in rates of nausea, urinary retention, or 30-day readmissions were observed between the groups.

Discussion:
In patients undergoing TKA with a spinal anesthesia, after adjusting for potentially confounding factors using propensity score matching, the use of mepivacaine was associated with shorter length of stay, less overall OMME requirements, and increased likelihood of home discharge, with no increase in complication rates. Based on these results, mepivacaine appears to be a viable alternative to bupivacaine for use in TKA rapid recovery protocols.
Estimation of Z-Scores of Cardiac Structures in Healthy Indian Pediatric Population
Authors: Trivedi Bhadra , Chokhandre Manish , Dhobe Poornima , Garekar Swati 
Published: September 2023

Introduction:
Nomograms of pediatric cardiac structures are an effective tool to differentiate between normal and abnormal changes in dimensions of the heart. There is impending need for nomograms of Z-Scores of echocardiographic data derived from Indian children.

Objective:
The main objective of this study is to gather echocardiographic data from the healthy Indian pediatric population visiting the pediatric cardiology outpatient clinic and to derive the Z-Scores for various cardiac structures.

Materials and Methods:
All the echocardiographic studies from an eligible normal Indian population at a single centre were assessed. All the studies were performed on a single vendor echocardiography machine using weight appropriate neonatal, pediatric, and adult probes.

Statistical Analysis:
Body surface area (BSA) was used as an independent variable in a nonlinear regression analysis for the predicted mean value of each of the 19 echocardiographically measured structures.

Results:
The total number of children evaluated during the study period was 596, with age ranging from newborn to 16 years. The total parameters collected in the study were 8102. The correlation with Haycock's BSA and an individual parameter was found to be the most sensitive predictor of normal progression with age. Relationship of individual parameters with BSA was represented in the form of graphs.

Conclusion:
This study of normal Indian pediatric population is the largest Indian study to date. The regression formulae along with the graphs can be used to acquire the Z score of 19 individual echocardiographic parameters.
Case Report: Outbreak of Nosocomial Myiasis by Cochliomyia macellaria (Diptera, Calliphoridae) in a Hospital in Colima, Mexico
Authors: Espinoza-Gómez Francisco , Rojas-Larios Fabian , Cruz-Sanchez Saulo , Rodriguez-Hernandez Alejandrina , Delgado-Enciso Iván 
Published: September 2023

ABSTRACT.
Myiasis in humans is a disease caused by larvae of various fly families. It mainly occurs in communities with poor sanitation and low socioeconomic status. Meanwhile intrahospital or nosocomial myiasis represents a rare phenomenon but is of relevance to public health. Here, we report an outbreak of myiasis caused by Cochliomyia macellaria in five patients hospitalized for several diseases at the Service of Internal Medicine of the Hospital Regional Universitario de Colima, Mexico during June and July 2021. Three patients were males and two were females, aged 37 to 83 years. All were affected by myiasis caused by larvae of the fly C. macellaria. Three patients underwent invasive mechanical ventilation; one had cutaneous basal cell cancer and one had advanced diabetic foot. This event occurred after 4 days of hospitalization and in the same hospital pavilion. Two patients died, and the others were discharged after treatment with antibiotics and ivermectin. We believe that this nosocomial cluster represents a more frequent phenomenon than reported in tropical countries, where authorities should pay attention to its timely detection, especially in vulnerable populations.
Scorpion Sting Envenomation, a Neglected Tropical Disease: A Nationwide Survey Exploring Perspectives and Attitudes of Resident Doctors from India
Authors: Kumar Akhilesh , Goyal Shilpi , Garg Mahendra K. , Gopalakrishnan Maya 
Published: September 2023

ABSTRACT.
Scorpion sting envenomation (SSE) is a commonly encountered and a significant problem in the tropics, affecting rural and marginalized communities. However, it is not formally listed as a neglected tropical disease (NTD) by the WHO. We designed this cross-sectional study to explore medical graduates’ and resident doctors’ perspectives on SSE as an NTD and to assess their experiences, knowledge, and confidence in managing these patients. An online questionnaire was developed, validated, and administered to interns and resident doctors across India. Adjusted odds ratios were calculated for factors predicting high self-reported confidence scores for managing scorpion stings using multivariable logistic regression. The final questionnaire contained 26 items including participant background, perspectives about SSE being an NTD, experiences, knowledge, and skills needed to manage, and prevent stings effectively. Of 454 participants, 69% opined that SSE was an NTD, and > 60% felt that SSE was inadequately addressed within undergraduate training. Predictors of high self-reported confidence scores in management competencies were residency in a clinical branch that commonly encountered SSE (internal/emergency medicine or pediatrics, P < 0.0001), having ever managed an SSE patient alone or as a part of a team (P < 0.0001), and attending a class or teaching session on SSE during undergraduate training (P = 0.048). Our results suggest that residents across India believe that there is an urgent need to declare SSE an NTD to increase its visibility, further paving the way for innovative multilevel cross-cutting solutions for mitigation. Designing authentic learning experiences can help produce competent and empathetic physicians in managing and preventing SSE.
Clinical, Gender, Socioeconomic Characteristics and Outcomes of Individuals Receiving Hepatitis B Treatment in Ethiopia: 18-Month Follow-Up
Authors: Tappata Manaswita , Farah Marina , Anugwom Chimaobi , Bisrat Eden , Seid Amir S. , Debes Jose D. 
Published: September 2023

ABSTRACT.
There is a lack of real-world data on hepatitis B (HBV) treatment in Africa. We conducted a single-center 18-month prospective cohort study in Ethiopia to understand clinical, laboratory, and demographic variables associated with HBV treatment. One hundred fifty HBV-positive patients were included: 51 on treatment, 99 with no treatment. Median age was similar between groups. Those on treatment were more likely to be male (86%), report higher coffee intake (90% versus 70%, P < 0.05), lower khat intake (0% versus 9%, P = 0.08), lower alcohol consumption (0% versus 5%, P = 0.1), and had attained higher levels of education (56% versus 42%, P = 0.19). Individuals on treatment had higher median aspartate aminotransferase (AST), alanine aminotransferase (ALT), HBV DNA, and median Aminotransferase-to-Platelet Ratio Index and Fibrosis-4 scores. At 6 and 12 months, those on treatment showed a decrease in median AST, ALT, and fibrosis scores and had less hepatocellular carcinoma development at 6 months (2% versus 4%). Our study highlights potential demographic disparities in HBV treatment as well as benefits in a real-life setting in Africa.
Kebijakan Penerbitan Perizinan Berusaha Dalam Sektor Pariwisata Beresiko Setelah Berlakunya UU Cipta Kerja Di Kabupaten Jember
Authors: Suhadi Manan , Erzal Wahyudi Ahmad Rihnu , Garpy Pyvico Fadera 
Published: September 2023

Pariwisata merupakan salah satu bidang yang ditingkatkan pemerintah sebagai tujuan pembangunan nasional karena kemampuannya dalam meningkatkan perekonomian nasional. Pengelolaan pariwisata yang dilakukan pemerintah sebagai instrumen peningkatan lapangan kerja, peningkatkan devisa negara, dan peningkatan terhadap pembangunan ekonomi nasional. Tujuan penelitian untuk mengetahui kebijakan penerbitan perizinan berusaha dalam sektor pariwisata beresiko (wisata alam parahlayang Jember) setelah berlakunya UU Cipta Kerja. Penelitian ini menggunakan metode yuridis normatif yaitu dengan mengimplementasikan dan mengkaji berbagai peraturan perundang-undangan yang berhubungan dan berlaku sebagai dasar penelitian. Metode pendekatan penelitian dengan pendekatan perundang-undangan (statue approach) dan konsep/pendapat pakar (conceptual approach). Teknik pengolahan data dilakukan dengan mengolah, memeriksa, dan meneliti sumber data dan pengumpulan data dilakukan dengan study online dan study keperpustakaan dengan mempelajari, membaca, dan memahami peraturan, teori, literatur, dan karya ilmiah yang berkaitan dengan pokok permasalahan penelitian. Hasil dari penelitian menjelaskan dalam UU No. 10/2009 Tentang Kepariwisataan terkait perizinan berusaha beresiko belum diatur secara rigid dalam Peraturan Menteri, namun dalam UU No. 6/2023 Cipta Kerja terdapat inovasi terkait mengenai perizinan berbasis resiko diatur dalam Peraturan Pemerintah, secara teori hukum maka yang lebih menguntungkan kedudukan peraturan perundang-undangan. Penelitian ini merekomendasikan kebijakan penerbitan perizinan berusaha beresiko pada sektor pariwisata di Kabupaten Jember segera dibentuknya Perda.
Prediction model of financial distress reporting of multifinance companies in 2017-2021 in Indonesia
Authors: Ismail Ilham , Ispriyadi Heri , Simanullang Saiful , Rukmana Heru Satria 
Published: September 2023

The urgency of this study is because the phenomenon of the Covid-19 pandemic is the cause of many multifinance companies to have an impact on decreasing the quality of financial performance so that it has the potential for financial distress, while the purpose of this study is to determine and analyze the effect of liquidity, solvency and profitability on one of the 7 most accurate bankruptcy prediction models. The sample method used is a purposive sampling technique with criteria, namely (1) companies engaged in financing (multi finance), (2) Meeting data needs, from 100 samples get 34 companies, analyzing data calculations by calculating financial performance and 7 bankruptcy prediction models, 1 bankruptcy prediction model is chosen that is the most accurate with the lowest number of companies predicting risk to see the effect using data regression panel because the financial statements are reviewed in a time series of 5 years period, the research method used with the number of research samples is 34 companies from 100 populations, with a comparative analysis method of 7 bankruptcy models, influence tests with classical assumption tests and regression panel data because the financial statements are reviewed in a 5-year time series period, the results obtained are that the analysis of financial performance is based on predetermined ratios Describes an increase every year in several companies, and indicates that 34 companies have very good financial positions. bankruptcy analysis from 7 methods, there are 3 companies 3 times in a row to get distress conclusions, namely Bosowa Multifinance, Anugerah Buana Central Multi Finance and Batavia Prosperindo Finance Tbk. In addition, the relevant bankruptcy prediction in this study uses a Z Score where the results are assessed because a positive Z Score value indicates a lower level of bankruptcy risk, The results of the influence test result that the variables of liquidity, solvency and profitability affect the Bankruptcy Prediction, the managerial implications obtained even though the company is considered good but still must be controlled and evaluated financial management every period.
Extension Model of Administration and Management for Business of Community Enterprise
Authors: Paijit Pensiri , Toomhirun Chalermsak , Khlibtong Jinda , Limunggura Tippawan 
Published: September 2023

This research was aimed to 1) Study successful implementation of community enterprises, 2) Study factors relating to administration and management for business of community enterprises, 3) Analyze, synthesize, and develop the extension model of administration and management for business of community enterprises, and 4) Assess the extension model of administration and management for business of community enterprises. The research method was Mixed Method. The tools used were an In-Depth Interview with purposive sampling of 8 Key informants and a Survey of 520 cases with a Structured Interview. Descriptive Statistics, Comparative statistics (T-test), Factor Analysis, and Multiple Regression Analysis were used. The results found that the factors related to business administration and management, product distribution plans, and marketing were at a high level ( = 4.19, SD.= 0.908), raw material quality inspection or source selection was at the highest level ( = 4.25, SD.= 0.892), continuous communication with community enterprise customers was at a high level ( = 4.03, SD.= 0.966). All 3 components, which were Business Operation, Business administration, and Business Promotion and Support components, affected the success of business administration and management. They could explain 41.10% of the variation in management success and business management services.
Potensi Antioksidan Ekstrak Daun Tempuyung (Shoncus Arvensis L.) Pada Dua Metode Pengeringan
Authors: Harun Nurhidayati , Khairunnisa Mutia 
Published: September 2023

Pengeringan merupakan tahapan penting dalam menjaga kestabilan senyawa, sehingga diperlukan perlakuan yang tepat terhadap ekstrak untuk mendapatkan senyawa metabolit agar memiliki khasiat. Penelitian ini bertujuan untuk mengetahui pengaruh metode pengeringan ekstrak terhadap aktivitas antioksidan daun tempuyung (Sonchus arvensis L.). Metode pengeringan ekstrak yang digunakan dalam melakukan penelitian ini ada dua metode yaitu dengan menggunakan metode pengeringan waterbath dan kombinasi antara waterbath dan oven. Aktivitas antioksidan dilakukan dengan menggunakan metode 1,1 difenil-2-pikrilhydrazil (DPPH) pengukuran nilai IC50 dilakukan replikasi. Analisis dilakukan dengan menggunakan SPSS dengan tingkat kepercayaan 95% . Hasil skrining fitokimia menunjukan kedua sampel menggunakan metode pengeringan ekstrak waterbath dan kombinasi waterbath dan oven mengandung flavonoid. Nilai rata-rata IC50 sampel ektrak tempuyung dengan metode pengeringan waterbath didapatkan hasil (72,37±37,78), ekstrak dengan pengeringan menggunakan kombinasi waterbath dan oven (79,6±8,39) Vitamin C sebagai kontrol positif (5,46±7,874). Hasil analisis One Way ANOVA diperoleh signifikansi p < 0,05 ada perbedaan nilai IC50 yang signifikan antara kelompok dilanjutkan dengan analisis post hock Tamhane’s perbedaan terjadi antara kelompok pengeringan dengan kontrol positif. Pada metode pengeringan tidak terdapat perbedaan nilai IC50 yang signifikan. Kesimpulan tidak terdapat pengaruh metode pengeringan ekstrak terhadap aktivitas antioksidan daun tempuyung.