bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspective of patients with first‐episode psychosis, their relatives, and mental health professionals on the design and usability of an app in clinical practice
Authors: Domínguez Marta , Sánchez‐Balcells Sara , Vila‐Badia Regina , Bergadà‐Sánchez Esther , Vilaplana Miriam , Ochoa Susana , Huerta‐Ramos Maria Elena , Del Cacho Nuria , Usall Judith , Peláez Trini , Coromina Marta 
Published: September 2023

AbstractAimTherapeutic non‐compliance remains the main difficulty for people with psychotic disorders, standing around 50% in people with schizophrenia. Lack of treatment adherence, either partial or total, to medication has economic and clinical consequences. E‐health technologies may be a promising therapeutic tool to improve adherence, with the subsequent reduction in clinical and economic burden. Our aims were to know the preferences on how technologies in mental health treatment should be for use in clinical practice, and to learn about the opinion and preferences on the use of technologies in mental health treatment from the perspectives of patients with FEP, their relatives, and mental health professionals.MethodsForty‐one patients with a diagnosis of first‐episode psychosis (FEP), 18 relatives and 49 mental health professionals were included in the study. They completed an online survey related to the use, availability and user‐skill of online platforms and apps created by a group of experts in psychosis and in the use of technologies. Data were summarized in frequencies, percentages, and means, and Chi‐square tests were used to calculate differences between‐groups.ResultsAn app directed to people with psychosis would be well received by users if it contains psychoeducational material, offers reminders for scheduled visits and treatment and allows online consultations.ConclusionsCo‐creating an app with users, their families and mental health professionals allows incorporating their preferences to increase its use, improve outpatient care and creating an app that is viable in clinical practice.
The putatively high‐altitude adaptation of macaque monkeys: Evidence from the fecal metabolome and gut microbiome
Authors: Li Dayong , Xia Wancai , Cui Xinyuan , Zhao Mei , Huang Kai , Wang Xueyu , Shen Jian , Chen Hua , Zhu Lifeng 
Published: September 2023

AbstractAnimals living in high‐altitude environments, such as the Tibetan Plateau, must face harsh environmental conditions (e.g., hypoxia, cold, and strong UV radiation). These animals' physiological adaptations (e.g., increased red cell production and turnover rate) might also be associated with the gut microbial response. Bilirubin is a component of red blood cell turnover or destruction and is excreted into the intestine and reduced to urobilinoids and/or urobilinogen by gut bacteria. Here, we found that the feces of macaques living in high‐altitude regions look significantly browner (with a high concentration of stercobilin, a component from urobilinoids) than those living in low‐altitude regions. We also found that gut microbes involved in urobilinogen reduction (e.g., beta‐glucuronidase) were enriched in the high‐altitude mammal population compared to the low‐altitude population. Moreover, the spatial–temporal change in gut microbial function was more profound in the low‐altitude macaques than in the high‐altitude population, which might be attributed to profound changes in food resources in the low‐altitude regions. Therefore, we conclude that a high‐altitude environment's stress influences living animals and their symbiotic microbiota.
Fatigue crack growth simulation using the moving mesh technique
Authors: Ammendolea Domenico , Greco Fabrizio , Leonetti Lorenzo , Lonetti Paolo , Pascuzzo Arturo 
Published: September 2023

AbstractThis work proposes a finite element (FE)‐based numerical model that uses the moving mesh technique for simulating fatigue crack propagation phenomena inside material components subjected to cyclic loads. Precisely, the computational mesh is adjusted during the numerical simulation according to conditions dictated by the criteria of fracture mechanics. Unlike standard FE procedures, which perform remeshing for each increment of the crack length, the proposed model updates the computational mesh only when FEs are distorted excessively because of the mesh nodes' motion, thus reducing computational burdens considerably. The validity of the proposed method is assessed through comparisons with existing experimental and numerical results.
Direct and indirect relationships of climate and land use change with food webs in lakes and streams
Authors: Barbosa Gedimar Pereira , Siqueira Tadeu 
Published: September 2023

AbstractAimClimate and land use change can independently affect food web structure. However, their direct and indirect relationships with food webs are not well‐understood. This is particularly relevant for freshwater ecosystems, which are strongly affected by global threats and differ substantially in attributes and functioning. Here, we investigated direct and indirect relationships between climate and land use changes and freshwater food web structure, while considering the differences between lakes and streams.LocationMulticontinental.Time periodCurrent.Major taxa studiedFreshwater taxa.MethodsWe compiled 51 food webs, spanning 12 countries and six continents to investigate the direct and indirect relationships between land use intensity, changes in air temperature and precipitation and food web structure, using structural equation modelling (SEM). We further tested how lake and stream food webs differ in their responses to environmental change by applying a multigroup analysis to our SEM.ResultsWe found that connectance was positively related to both land use intensity and increases in air temperature and precipitation in stream food webs, whereas in lakes, it was only related to temperature. These findings suggest a dominance of generalists where conversion to agriculture and urbanization has been intensified, and temperature has increased. Food web vertical structure was negatively related to land use and increases in air temperature and precipitation, but climatic predictors were only linked to network structure through a negative relationship with the fraction of top consumers.Main conclusionsWhile land use intensity was directly related to food web structure, complex relationships between changes in climate and network topology were mediated by the fraction of top consumers. Also, as food webs in lakes and streams responded differently to land use and climate change, we suggest that their intrinsic characteristics must be explicitly considered to fully understand the effects of global changes on freshwater biodiversity.
How does social density influence consumer subjective well‐being under high environmental uncertainty?
Authors: Wu Linwan , Zhang Chi 
Published: September 2023

AbstractSubjective well‐being is an important research topic in consumer psychology. We conducted two experimental studies to examine the joint effects of environmental uncertainty and social density on consumer subjective well‐being. The first study (N = 200) adopted a 2 (environmental uncertainty: high vs. baseline) × 2 (social density: high vs. low) design. Analysis of covariance (ANCOVA) analysis indicated that low social density improved consumers' life happiness after they experienced high environmental uncertainty. Moderated mediation analysis using the PROCESS macro found that the psychological process of control compensation was the underlying mechanism. The second study (N = 193) aimed to further demonstrate the control compensation effect and adopted a 2 (control boost: boost vs. no boost) × 2 (social density: high vs. low) design. ANCOVA analysis indicated that low social density improved life happiness reported by consumers who received no control boost after they experienced high environmental uncertainty. These findings provide significant implications for consumer advocacy from theoretical and practical standpoints.
Real‐world data show high efficacy of IL23 inhibitors guselkumab and risankizumab in psoriatic arthritis and difficult‐to‐treat areas
Authors: Vaiopoulos Aristeidis G. , Dalamaga Maria , Katsimbri Pelagia , Koumourtzis Marios , Lampadaki Kyriaki , Theodoropoulos Konstantinos , Theotokoglou Sofia , Kanelleas Antonios , Syrmali Anna , Filippopoulou Alexandra , Zoupidou Konstantina , Katoulis Alexander , Papadavid Evangelia 
Published: September 2023

AbstractBackgroundPsoriasis and psoriatic arthritis are chronic inflammatory skin and joint diseases requiring effective therapies. Although clinical studies have shown the efficacy of IL‐23 inhibitors, real‐world data are limited.MethodsWe conducted a single‐center retrospective Greek study enrolling patients with psoriatic arthritis and moderate‐to‐severe plaque psoriasis being treated at our multidisciplinary psoriasis outpatient clinic. Our aim was to investigate the efficacy and safety of IL‐23 inhibitors guselkumab and risankizumab. Additionally, we sought to determine the clinical characteristics affecting treatment response. Primary endpoints were the evaluation of absolute Psoriasis Area and Severity Index (aPASI) and Disease Activity Index for Psoriatic Arthritis (DAPSA) at week 24.ResultsFifty‐nine patients (55.9% male, 69.5% early onset) with a mean age of 51.7 years were included. Twenty‐four patients (40.7%) had a concomitant psoriatic arthritis. Obesity was the main comorbidity (49.2%) with a mean body mass index (BMI) of 31.3 kg/m2. Additional comorbidities were hypertension (44.1%), dyslipidemia (32.2%), and diabetes (18.6%). Only eight patients (13.6%) were naïve to previous systemic treatments, whereas 40 patients (67.8%) were bio‐experienced. A statistically significant improvement of aPASI and DAPSA was demonstrated after 4, 16, and 24 weeks of treatment (P < 0.05). IL23 blockers were also efficacious in difficult‐to‐treat areas. Clinical outcome was affected from previous treatment with biologics. Treatment response was the same between guselkumab and risankizumab (P > 0.05).ConclusionThis real‐world study confirms the efficacy and safety of guselkumab and risankizumab in psoriatic arthritis and psoriasis reported from clinical trials.
Quality evaluation of tomatoes coated by an advanced electrostatic spray coating system
Authors: Mehta Deepak , Sahu Goutam , Patel Manoj Kumar , Chauhan Aarti , Agrahari Vishal , Kumar Anup , Nayak Manoj Kumar , Matche Rajeshwar 
Published: September 2023

SummaryA critical assessment was carried out to investigate the impact of electrostatic spray coatings as compared to dip coatings on tomatoes which were conducted at 30 ± 2 °C and 60% RH for a period of 30 days. In this paper, the impact of developed polysaccharide‐based coatings (alginate and cellulose coatings with clove oil) and commercially available wax‐based coatings (VMW50+) was compared to that of uncoated tomatoes. The application of alginate‐ and cellulose‐based electrostatically charged sprays was found to significantly (P < 0.05) reduce the weight loss, firmness, colour and bioactive compound degradation and overall flavour loss as compared to uncoated and dip‐based coating during the storage period of 30 days. Moreover, alginate‐ and cellulose‐based electrostatically charged spray coating were more efficient in delaying the spoilage of tomatoes by 20 days as compared to the uncoated one. A significant level of charge‐to‐mass ratio has been achieved, which confirmed the chargeability of coating materials. These findings confirmed the capability of electrostatically charged sprays to extend the shelf life and preserve the overall quality of tomatoes during storage.
The functionality and extraction of protein from sorghum, finger millet, and Kodo millet: a review
Authors: Singh Poornima , Singh Rahul , Bhadauria Vivek , Singh Harinder 
Published: September 2023

SummaryThe world's growing and sustainable supply of proteins and other healthy foods is needed to meet the ever‐increasing demands for human and cattle feed. Research and development in recent decades are directing us towards millets, which are climate‐resistant as well as protein, and micronutrient rich. Proteins constitute around 7%–11% w/w of millet seeds. Proteins serve critical functions in grain nutritional quality and have an impact on the nutrition accrued to the user and the end‐user. Sorghum, kodo and finger millets are cultivated in India, the United States, Niger, China, Nigeria and other countries. Sorghum has received more research attention than kodo and finger millet for protein content and structure, probably due to its higher production volume. This review is a critical analysis of the functionality of proteins from sorghum, kodo, and finger millet and their behaviour when influenced by their content, structure, extraction method and presence of starch, as well as changes that occur in these proteins when various modifications are done for possible use in a variety of food products.
The development of Jack Jumper ant venom immunotherapy: our 25 years' experience
Authors: Wanandy Troy , Le Thanh‐Thao A. , Lau Wun Y. , Wiese Michael D. , Heddle Robert J. , Brown Simon G. A. 
Published: September 2023

AbstractJack Jumper ant venom allergy is a uniquely Australian medical issue. The stinging ant is a leading cause of insect venom allergy in south‐eastern Australia. An effective venom immunotherapy‐based treatment was successfully developed by the Tasmanian Jack Jumper Allergy Research group. This paper provides a synopsis of our 25 years' research journey in developing this evidence‐based treatment modality.
Comparison of the effects of laparoscopic and open hysterectomy on surgical site wound infections in patients with endometrial cancer: A meta‐analysis
Authors: Yang Nian , Zhou Fei 
Published: September 2023

AbstractThis meta‐analysis aimed to compare laparoscopic hysterectomy (LH) and open hysterectomy (OH) in terms of surgical site wound infection, length of hospital stay, and postoperative complications in patients with endometrial cancer (EC). PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP, and Wanfang databases were comprehensively searched for studies on OH and LH for EC published between 2008 and July 2023, in any language. The literature was screened according to the inclusion and exclusion criteria, and the quality of the included case–control studies was assessed using the Newcastle‐Ottawa Scale. Data were collated and analysed using Stata 17.0 software. A total of 1245 articles were screened according to the search strategy, and ultimately 15 studies were included in this meta‐analysis, with a total of 1606 patients with EC, of which 751 were treated with LH and 855 with OH. The results showed that the rate of postoperative wound infection was significantly higher (OR: 0.290; 95% CI: 0.169–0.496, p < 0.001), the length of hospital stay was significantly longer (SMD: −1.976, 95% CI: −2.669 to −1.283, p < 0.001), and the incidence of postoperative complications was significantly higher (OR: 0.366; 95% CI: 0.280–0.478, p < 0.001) in the OH group than in the LH group. This study showed that LH was superior to OH for the treatment of EC and is associated with a lower rate of wound infection, shorter length of hospitalisation, and a reduced risk of complications. Thus, our findings support the choice of LH over OH for EC.
Directors’ and officers’ liability insurance and corporate cash holdings: From principal–principal perspective
Authors: Liang Quanxi , Gao Wenlian , Yan Lijuan 
Published: September 2023

AbstractThis study examines the effect of directors’ and officers’ liability insurance (D&O insurance) on corporate cash holdings in China. We propose a collusion theory in which D&O insurance can exacerbate the conflicts of interest between controlling and minority shareholders by shielding directors and officers from shareholder litigation in emerging countries. Consistent with our expectation, we find that insured firms tend to have high cash holdings that are appropriated by both controlling shareholders and directors/officers rather than being invested or paid to shareholders. Moreover, the positive relationship between D&O insurance and cash holdings is more pronounced in firms with high litigation risks, whereas the effect is attenuated in firms with political connections, strong external monitoring mechanisms and strong controlling shareholder power. Compared with uninsured firms, the market discounts the value of cash holdings for insured firms.
Disentangling stock return synchronicity from the auditor's perspective
Authors: Hasan Iftekhar , Micale Joseph A. , Wu Qiang 
Published: September 2023

AbstractThis paper investigates a firm's stock return asynchronicity through the auditor's perspective to distinguish whether this asynchronicity can proxy for the company's firm‐specific information or the quality of its information environment. We find a significant and positive association between asynchronicity and audit fees after controlling for auditor quality and other factors that affect audit fees, suggesting that stock return asynchronicity is more likely to capture a company's firm‐specific information than its information environment. We also find that asynchronous firms are more likely to receive adverse opinions on their internal controls over financial reporting, but are associated with lower costs of capital and auditor litigation, providing further evidence in support of the firm‐specific information argument. Asynchronicity's positive association with audit fees is driven by firms with higher accounting reporting complexity, suggesting stock return asynchronicity captures a firm's complexity, resulting in more significant efforts by the auditor.
Inpatient pediatric nursing staff experiences treating psychiatric patients: A mixed methods study
Authors: DeAlmeida Katelyn , Blanco Keli , Metz Katherine , Bohr Nicole L. 
Published: September 2023

AbstractProblemA gap in the literature exists attempting to understand the impact that the influx of pediatric psychiatric patients has had on inpatient general medicine pediatric nursing staff.MethodsA mixed‐method research study was conducted among full‐ and part‐time pediatric nurses and nursing assistants working on general pediatric units. Quantitative data was collected via an anonymous survey using the Professional Quality of Life Scale version 5 and Support Appraisal for Work Stressors scale. Surveys were followed by semistructured interviews.FindingsOf the 158 staff eligible, 47 (29.7%) participated in the quantitative portion. [Correction added on 29 September 2023, after the first online publication: In the preceding sentence, the participation rate was revised from 23.5% to 29.7% in this version.] Significant differences were found between roles, with nurses experiencing lower levels of compassion satisfaction and higher levels of burnout. Role differences were seen in supervisor support and nonwork support, with nurses reporting less support from both. Supervisor support showed a significant correlational relationship with compassion satisfaction and burnout. Nonwork support showed similar correlations with compassion satisfaction and burnout. Themes that emerged from the interviews were Barriers to Care, Emotional Impact, and “Help Me Help You.”ConclusionNurses may be at greater risk for compassion fatigue due to perceived inadequate support from leadership, unclear role expectations, and lack of resources.
Catheter ablation approach and outcome in HIV+ patients with recurrent atrial fibrillation
Authors: La Fazia Vincenzo Mirco , Pierucci Nicola , Mohanty Sanghamitra , Gianni Carola , Della Rocca Domenico Giovanni , Compagnucci Paolo , MacDonald Bryan , Mayedo Angel , Torlapati Prem Geeta , Bassiouny Mohamed , Gallinghouse Gerald Joseph , Burkhardt John D. , Horton Rodney , Al‐Ahmad Amin , Di Biase Luigi , Natale Andrea 
Published: September 2023

AbstractIntroductionEarlier studies have shown a clear association between severity of human immunodeficiency virus (HIV) infection and incident atrial fibrillation (AF). We present the long‐term outcome of catheter ablation (CA) and electrophysiological characteristics in HIV+ AF patients.MethodsThis study evaluated 1438 consecutive AF patients [31 (2.15%) with HIV and 1407 (97.8%) without HIV diagnosis] undergoing their first CA at our center. A total of 31 HIV patients and 31 controls were generated by propensity matching, based on calculated risk factor scores, using a logistic model. During first procedure, all received isolation of pulmonary vein (PV) + posterior wall and superior vena cava. Non‐PV triggers, defined as ectopic triggers originating from sites other than PVs, were identified at the redo ablation with high‐dose isoproterenol challenge.ResultsClinical characteristics were not different between the groups. When compared to the control, by the end of 5 years after the first procedure, recurrence was significantly greater in HIV group [100% vs. 54%, p < .001]. Among patients that underwent redo ablation non‐PV triggers were higher in HIV group [93.5% vs. 54%, p < .001], and most frequently originated from the coronary sinus [67.7% vs. 45.2%, p < .001] and left atrial appendage [41.9% vs. 25.8%, p < .001]. After focal ablation of non‐PV trigger, no difference in arrhythmia recurrence between two groups [80.6% vs. 87.1%, p = .753] at 1‐year follow up was found.ConclusionOur findings suggest that non‐PV triggers are highly prevalent in HIV+ AF patients resulting in higher rate of the mid‐ and long‐term arrhythmia recurrence.
Periodontitis and the incidence of metabolic syndrome: An 8‐year longitudinal study of an adult Japanese cohort
Authors: Saito Mizuki , Shimazaki Yoshihiro , Yoshii Saori , Takeyama Hideo 
Published: September 2023

AbstractAimTo examine the effect of periodontitis on the development of metabolic syndrome (MetS) and MetS components.Materials and MethodsThis study included 4761 participants aged 30–74 years who underwent health examinations at both baseline and 8‐year follow‐up. The Japanese MetS criteria were used for diagnosis. The Community Periodontal Index was used to assess periodontal status. The association between periodontal status and MetS incidence was examined by Poisson regression analysis.ResultsMultivariate analysis revealed that individuals with a ≥6 mm periodontal pocket had a significantly higher relative risk (RR) for MetS onset, as compared to individuals without deep periodontal pockets (adjusted RR 1.30, 95% confidence interval [CI]: 1.01–1.67). Compared to individuals without a deep periodontal pocket, individuals with a ≥6 mm periodontal pocket had significantly higher RRs for developing two components of MetS; the RRs were 1.25 (95% CI: 1.01–1.56) for abdominal obesity and 1.39 (95% CI: 1.03–1.86) for hyperglycaemia.ConclusionsIndividuals with periodontitis had a significantly higher risk of MetS onset, possibly due to the influence of periodontitis on abdominal obesity and hyperglycaemia.