bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences from a procedure in high technology environments from a perspective of parents to children with autism spectrum disorder: a systematic review
Authors: Pettersson Emelie , Christensen Berit Møller , Berglund Ingalill Gimbler , Nylander Elisabeth , Huus Karina 
Published: March 2023

Abstract
Background
Children with autism spectrum disorders are frequent visitors in high technology environments, and their needs might differ from typically developed peers. A procedure in high technology environment can constitute a challenge for those children and their parents, as the environments presents many challenges in relation to the child’s impairment. The aim of this systematic review was to explore the experiences that children with autism spectrum disorders, and their parents have of procedures in a high technology environment.
Method
For this systematic review, the following sources were searched: Cochrane CENTRAL trials, CINAHL, Dentistry & Oral Sciences Source, MEDLINE, PsycInfo, Scopus, and the Web of Science Core Collection. Search terms included variants of the following concepts: 1) children with autism spectrum disorder and/or their parents; and 2) anesthesia or radiographic departments. Publications were not limited by date or study design.
Result
Out of 13389 bibliographic records, nine studies were eligible for synthesis. None of the studies reported the children’s experiences, all nine reported the parents’ experiences. Only one study was from the radiographic context. After a renewed search during October 2022 one more study was eligible for synthesis. The parents’ experiences were both positive and negative and categorized into two main categories 1) challenges in a new environment; and 2) health care professionals’ approaches.
Conclusion
There is a lack of studies describing children’s experiences of procedures in high technology environments. The parents experienced a need for the health care professionals to work in structured ways with their child and to be able to make adaptations before the encounter in conjunction with the procedure.
Systematic review registration:
This systematic review was registered in advance on the Open Science Framework, https://doi.org/10.17605/OSF.IO/5TXWJ.
Sentinel lymph node biopsy versus observation in clinically and ultrasound node negative early stage breast cancer
Authors: Fayed Mohannad , Daoud Mohammed A. , Kassem Loay , Wessam Rasha , Mokhtar Sherif , khlaff Emad 
Published: March 2023

Abstract
Background: The gold standard for axillary staging in node-negative early-stage breast cancer is sentinel lymph node biopsy (SLNB). Axillary lymph node dissection (ALND), SLNB, and axillary radiotherapy have all been associated with axillary problems, but at a smaller incidence with SLNB alone than with ALND. The Z0011 trial demonstrated that there is no benefit from axillary dissection in the context of positive SLN.
Aim: Compare locoregional recurrence, disease free survival (DFS), and overall survival (OS) between SLNB and observation in patients with early stage clinically node negative breast cancer by palpation and preoperative ultrasonography.
Methodology: Candidates for Breast Conservative Surgery include 60 patients with clinically and radiologically node-negative early breast cancer, randomized to one of two groups: Study group (group A): 30 patients underwent BCS with no further axillary surgery. Control group (group B): 30 patients underwent BCS and SLNB. Follow up was done to detect the two years locoregional recurrence, DFS and OS.
Results: After a two-year follow-up, there was no discernible difference between the two arms in terms of axillary, local, or metastatic recurrence. Regarding post-operative arm edema, both arms significantly differ from one another.
Conclusion: Omission of axillary surgery in T1 and some cases of T2 N0 breast cancer patients appears safe and applicable without affecting locoregional recurrence and axillary/nodal recurrence. Longer term follow-up is needed
A fast interpolation-based multi-objective evolutionary algorithm for large-scale multi-objective optimization problems
Authors: Liu Zhe , Han Fei , Ling Qinghua , Han Henry , Jiang Jing 
Published: March 2023

Abstract

Evaluating large-scale multi-objective problems is usually time-consuming due to a large number of decision variables. However, most of the existing algorithms for large-scale multi-objective optimization require a large number of problem evaluations to obtain acceptable results, which makes the optimization very inefficient. In this paper, a fast interpolation-based multi-objective evolutionary algorithm is proposed for solving large-scale multi-objective optimization problems with high convergence speed and accuracy. In the proposed algorithm, the decision variables are generated based on the information of a small number of variables by the interpolation function. With this approach, only a small number of variables need to be optimized in the proposed algorithm, and the search space can be reduced greatly to improve the convergence speed, and to make it possible to obtain satisfactory results with a relatively small computation cost. The experimental results verified that our proposed algorithm outperforms other compared algorithms in terms of convergence speed and convergence accuracy on 108 test instances with up to 1000 decision variables. Additionally, a parametric study is provided to investigate the best parameter setting for the proposed algorithm.
Advances in the application of gene knockout technology in bacterial drug resistance research
Authors: Tong Chunyu , Liang Yimin , Zhang Zhelin , Wang Sen , Zheng Xiaohui , Liu Qi , Song Bocui 
Published: March 2023

Abstract
Gene knockdown has been confirmed as a common problem-solving method in biology. It is effective in investigating bacterial drug resistance. The technologies of gene knockdown comprise zinc-finger nuclease technology (ZFN technology), suicide plasmid vector systems, transcription activator-like effector protein nuclease technology (TALEN technology), Red homologous recombination technology, CRISPR/Cas, and so forth. To be specific, Red homologous recombination technology, CRISPR/Cas9 technology, and suicide plasmid vector systems have been the most extensively used technologies for the knockdown of bacterial drug resistance genes. The three above-described technologies have been employed in a considerable number of studies to obtain significant results in the research on bacterial gene functions. This study aims to provide an overview of effective gene knockout methods that are currently used for genetic drug resistance testing in bacteria and to provide a reference for the selection of gene knockout techniques.
Efficacy and Safety of Cysteamine-Isobionicamide Complex in Postinflammatory Hyperpigmentation: A Randomized, Double Blinded, Vehicle-Controlled Trial
Authors: Liu Tzu-Li , Tsai Tsung-Fu , Lai Yi-Jing , Ng Chau Yee 
Published: March 2023

Abstract
Postinflammatory hyperpigmentation (PIH) is a common acquired hyperpigmentation disorder that can cause significant psychosocial impacts. Cysteamine has been shown to be an effective depigmenting agent for hyperpigmentation disorders, and a clinical trial was conducted to assess the efficacy and safety of cysteamine-isobionicamide complex for treating PIH. Forty patients were randomized into treatment and control groups, with assessments collected at baseline, week 4, 8, and 16. The treatment group showed significant improvement in dermatological assessments, MASI score, TPHI score, and life quality score compared to the control group. Mexameter® and VISIA skin analysis also showed significant improvement in the melanin index and erythema index score at week 16, with cellular resolution OCT imaging revealing decreased melanosome capping and fewer hyper-reflective melanophages. This study suggests that the cysteamine-isobionicamide complex has the potential to be a viable treatment option for PIH.
Performance of AMF, Rhizobium and its Exopolysaccharides in Drought and Disease Resistance of Zea mays L. (Maize)
Authors: Akpeji Stephanie Clara , Bukola Christianah Adebayo-Tayo , Odunayo Joseph Olawuyi , Ossai Chukwunalu Okolie 
Published: March 2023

Abstract
The roles of biologically synthesized Exopolysaccharides (EPS) from Rhizobium and Arbuscular Mycorrhizal Fungus (AMF) in tolerating biotic and abiotic stresses were investigated in this study. The treatments effect of Rhizobia, Rhizobial-exopolysaccharides (Bradyrhizobium japonicum USDA 110) and AMF (Glomus clarum), singly and in combination were evaluated on two varieties (TZmI1466 and TZmI1297) infected by Bipolaris maydis (BM) and subjected to water stress. Screen house experiments were conducted using a complete randomized design with three replicates. The growth characteristics, root and shoot biomass and disease incidence data were collected and analyzed by descriptive statistics and one-way ANOVA at α0.05.Seed treatments with EPS had the highest significant (P < 0.05) effect on Bipolaris maydis (1.67) and drought in maize. The effect of Rhizobium, exopolysaccharide and AMF treatments against B. maydis showed that Rhizobium alone significantly increase the growth characteristics but suppressed the B. maydis effect. The exopolysaccharide improved all the growth parameters during water stress, while AMF-treated plants significantly improved plant height (43.41 cm ± 2.30), leaf area (114.08 cm2 ± 7.89) and stem diameter (2.58 ± 0.10 cm). Maize variety TZm11297 performed best for the number of leaves (8.48 ± 0.12 cm2) and leaf area (116.97 ± 2.94 cm2) but not significantly different from other growth characteristics in TZm14466.Inoculation with AMF and Rhizobium demonstrated enhanced growth and development of maize plants. Microbial inoculants tolerated drought stress in maize thus, ensuring enhanced crop productivity.
Radiologic and surgical evidence of pre-tracheal anatomies and implications for safe procedures in elderly oncologic patients: implications for elective or emergent tracheotomies
Authors: Zhu Dan , Sun Bingbing , Dong Yabing , Shen Yi , Ma Chunyue , Sun Lulu , Lv Xiang , Bai Guo , Gao Weijin 
Published: March 2023

Abstract

Background
To assess the anatomical relationship and age-related variability of the anatomies in the pre-tracheal space in elderly patients with head and neck cancers and to guide tracheotomy with clinical evidence for either planned or improvised procedures.
Methods
From January 2019 to February 2022, hospitalized head and neck cancer patients aged over 65 years (127 cases) and under 65 years (74 cases) were enrolled in this study as the observation and the control groups, respectively. All these patients received contrast-enhanced CT scans, ablative operations and tracheotomies for primary head and neck cancers. The radiographic reconstructions of vascular morphologies were compared, focusing on three target vessels: anterior jugular veins (AJVs), innominate arteries (IAs) and inferior thyroid plexuses (ITVPs). The upper locations of the isthmus, and the largest diameters of thyroid glands were compared as well. In addition, surgical exposure of those vessels was recorded during tracheostomies to verify these radiologic findings. The tracheotomy procedure-related complications were also compared.
Results
A total number of 201 patients (115 males and 86 females) were identified in this study. The mean age of the elderly group reached 72.0 years (range: 65–87 years), most of whom (41.7%) were with oral or oropharyngeal cancer. The proportion for single-branch type AJVs in the elderly group (11.9%) was higher than that in the young counterpart (8.2%), though no statistical difference was found (P = 0.701). Radiologically speaking, the IAs were categorized as the low-bifurcation (104 cases, 51.7%), high-bifurcation (n = 37, 18.4%), high-platform (27, 13.4%), low-platform (30, 14.9%) and variant types (3, 1.5%). Age-related changes of IA types were found between the elderly and the young groups (P < 0.01), especially for the platform IAs which might interfere with tracheal exposure. This phenomenon was also closely related to the intraoperative tracheotomy findings (rn=0.59, P < 0.01). Besides, for the ITVPs, the common-trunk types were mostly found in the elderly group (40%).
Conclusions
Considering the age-related changes, the evaluation of the pre-tracheal anatomies based on radiographic evidence can facilitate safer tracheotomies in elderly patients. Besides, implications for impromptu tracheotomies may also be drawn with knowledge of these variable anatomies.
Evaluation Model of Cultural Heritage Tourist Attractions Based on Network Virtual Resource Sharing and Real-time Information Processing
Authors: Rong Ai , Jianwei Song 
Published: March 2023

Abstract
With the continuous development of modern society, people's demand for the network is also rising. Because of its powerful function, wide coverage and other advantages, people in modern society have higher and higher utilization rate of the network, and many things are realized with the help of the network. At the same time, some new business based on the network is emerging. The rapid development of network technology makes many people rush for it. This paper mainly studies how to improve the cache technology, reasonable and effective allocation of resources, so that people can get a better experience. This paper studies the suitability evaluation of tourism development of regional cultural heritage resources by using Delphi method and AHP analytic hierarchy process, and infiltrates the evaluation items into various levels, such as natural environment conditions, social and economic conditions, resource combination levels and so on. Through the analysis and comparison of different geographic information, we can clearly understand whether the region is suitable for tourism and the spatial differences of some regions. To a certain extent, it lays the foundation for the future development of cultural heritage tourist attractions and the spatial analysis based on GIS, which is consistent with the tourism suitability evaluation index in the field of regional cultural heritage. When comparing the data with different measurement levels, we can directly determine the characteristics of the spatial differences of different cultural heritage resources, which depends on the value of resources and location conditions of a specific region.
Immunological and Prognostic Role of Cell Differentiation Trajectory Defined Gene Signature in Glioma
Authors: Hua Shi , Cheng Yanhao , Dai Chao , Wang Wenlai , Li Hongyan , Lu Yucheng 
Published: March 2023

Abstract
Glioma was characterized by its severe cellular heterogeneity during cell differentiation. Based on scRNA-seq and high throughput sequencing data, this research revealed the potential connections between cell differentiation trajectory and immune landscape in glioma. Glioma differentiation-related genes (GDRGs) were extracted from cell differentiation trajectories to establish a three-subtype molecular classification. Enrichment analysis indicated that GDRGs were involved in cell differentiation, intercellular adhesion, cytotoxicity, and cell cycle. ESTIMATE and CIBERSORT analysis showed that GDRGs and macrophages-related immune checkpoints (CD163, CD206, LILRB4, LILRB2, LILRB1, CD47, and SIRPα) promoted M2-dominated immune landscape in glioma. Finally, a novel prognostic risk score (RS) signature and nomogram based on 8 GDRGs (SOX4, MEX3A, EGFR, NES, ENC1, NEFL, NNAT, and TMSB15A) were established to predict the patient's 3-years and 5-years OS In conclusion, the molecular subtypes defined by cell differentiation trajectories predicted the M2-dominated immune landscape. GDRGs named SOX4, MEX3A, EGFR, NES, ENC1, NEFL, NNAT, and TMSB15A could be regarded as novel prognostic signatures and potential targets for immunotherapy.
Marine and Not Terrestrial Resources Support Nearshore Food Webs Across a Gradient of Glacial Watersheds in the Northern Gulf of Alaska
Authors: Schloemer James , Munk LeeAnn , Iken Katrin 
Published: March 2023

Abstract
Estuaries are among the most productive ecosystems on Earth, yet are especially at risk in high-latitude regions due to climate-driven effects on the connected terrestrial and marine realms. Warming in the Northern Hemisphere exceeds the global average and is a major cause of the rapid melting of glaciers. As a result, the timing and magnitude of freshwater discharge into estuaries is subject to increase during the peak in glacial meltwater, ultimately affecting the riverine flux of nutrients and organic matter (OM) from the land to coastal environments. Intertidal communities near the outflow of rivers often rely on supplementing autochtonous (marine) food sources with allochthonous (terrestrial) subsidies, even though terrestrial OM can be problematic for marine consumers to assimilate. We investigated if terrestrial matter subsidizes nearshore food webs in northern Gulf of Alaska watersheds, and if the relative proportion of terrestrial versus marine OM supporting these food webs differed with watershed glacial cover characteristics and with seasonal glacial discharge regimes. We employed a Bayesian stable isotope mixing model to determine the contribution of marine (phytoplankton, macroalgae) and terrestrial (vascular plant) sources to the diets of grazing/detritivore and filter/suspension-feeding coastal invertebrates at the outflows of watersheds of varying glacial influence and across various discharge periods. Additionally, we conducted a distance-based redundancy analysis to investigate the effects of watershed-characteristic sourcing and transport of terrestrial OM on nearshore consumer diets. The diets of both feeding groups were predominantly marine (> 90%) and varied little among sites or glacial discharge periods. However, consumers were depleted in 13C isotopes with increasing glacial cover; the significant watershed descriptors suggest that this change was more associated with discharge effects on marine primary production rather than consumption of terrestrial OM by the invertebrates. These results suggest that, while watershed exports may influence the stable isotope composition of OM sources, the diets of these feeding groups are mostly decoupled from terrestrial influence during the time of sampling. Our results suggest that marine OM availability in the study system is not limiting, and terrestrial OM subsidies in such productive systems are not needed to support nearshore food webs.
An efficent water quality prediction and evaluation method based on the DBN-LSTM model
Authors: Fan Bing , Zhao Zhiyao 
Published: March 2023

Abstract
Currently, water environmental issues have been severe. Water quality not only affects the ecological balance of nature but is also closely related to human lives. Therefore, an accurate water quality prediction and assessment can prevent water eutrophication, thus protecting the environment and improving people's quality of life. Previous studies have shown that the Long Short-Term Memory (LSTM) neural network has a good performance in time series prediction. In view of that, this paper proposes a neural network model that integrates the Deep Belief Network (DBN) and LSTM network for water quality prediction. The real data are used to predict water quality, and the DBN network is used to extract data features, which are then fed to the LSTM network. The proposed combined model is verified by experiments, and experimental results show that the proposed DBN-LSTM model can significantly improve prediction accuracy compared to the LSTM. The results indicate that the addition of the DBN network can improve the feature extraction and denoising performances on various datasets. The proposed water quality prediction model is compared with both single- and multiple-factor evaluation methods. The comparison results show that the DBN-LSTM model outperforms the LSTM model in terms of prediction accuracy, where it can be used in water quality monitoring management and risk assessment.
NeighbourGroups: a machine learning classification tool that assigns microbial multi-locus genotypes to clusters
Authors: Veltcheva Dessislava , Richer Stephen , Sheppard Samuel , Varga Margaret , Colles Frances , Bonsall Michael , Maiden Martin 
Published: March 2023

Abstract
Robust microbial classification systems are essential, but their definition is complicated by the large size and high diversity of microbial populations combined with a widespread horizontal genetic exchange. Multi-locus approaches that index gene variation without explicit phylogenetic classification mitigates these problems, but reproducibly defining high-level groups remains problematic. We describe a generalisable machine learning approach, 'NeighbourGroups', that reproducibly, robustly, and rapidly classifies multi-locus sequence types with defined precision.
Burn after read: a rewritable multiplexing optical information storage and encryption method
Authors: Xia Kangwei , Hu Zhihao , Guan Junyu , Zheng Shengteng , Chai Zihua , Wu Shengzhi , Liu Dong , Su Jia , Shi Fazhan , Wang Ya 
Published: March 2023

Abstract
Information storage and security are the building blocks of the information age. Optical information storage is a low-cost, robust, and high-capacity storage technique. Discovering new optical information storage media and technique with beyond binary capacity and enhanced security is in demand. Here we demonstrate a beyond-binary, "burn after read" and rewritable multiplexing optical information and encryption method via Ce:YAG trapping states. We find that the thermo-luminescence (TL) intensity of Ce:YAG trapping states is writing light power dependent, enabling multi-gray-level information storage and encoding. We present a new strategy to encode multiplexing information in a single pixel, increasing the storage capability. Meanwhile, the "burn after read" feature protects the data from secondary leakage. This method has wide applications in data storage, anti-counterfeiting, and encryption.
The Seafood Trade and Nutritional Access
Authors: Liu Yaqin , Smith Martin , Dietz David , Leaning Dustin Colson , Abbott Joshua , Smyth Adam 
Published: March 2023

Abstract
Globalization of seafood markets raises concerns about nutritional insecurity, as low-income nations trade away nutrient-dense seafood to high-income nations. However, this narrative ignores the nutritional contributions of seafood that low-income nations import due to reciprocal trade. We utilize a novel dataset connecting country-level seafood trade flows to product-specific data on nutrient concentrations to investigate how seafood trade affects nutritional availability to residents of developing nations in terms of nutrient density per dollar. We find compelling evidence across three macronutrients and nine micronutrients that developing nations pay lower prices for nutrition in imported seafood than developed nations. We demonstrate that import prices reflect values of nutritional characteristics but also premiums for freshness, particular species, convenient product forms such as fillets, and trophic level. We show that a significant portion of the nutritional bargain for low-income nations reflects differences in the non-nutritional characteristics of seafood imports between developed and developing nations.