bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of extent of resection on the survival of glioblastoma multiforme
Authors: Chaulagain Dipak , Smolanka Volodymyr , Smolanka Andriy , Havryliv Taras 
Published: September 2023

Background. Glioblastoma Multiforme (GBM) is the most prevalent form of brain cancer. The effect of Extent of Resection (EOR) on GBM survival is controversial. EOR degree, pre- and postoperative tumour volume estimation, and significance to residual tumour volume are still challenged. GBM has a 14-month Overall Survival (OS) rate. There is no evidence of a link between EOR and OS survival. We wish to determine whether GBM tumour removal increases survival.
Methods. At the Regional Center for Neurosurgery and Neurology in Uzhhorod, Ukraine, we conducted a retrospective evaluation of 86 consecutive patients diagnosed with glioblastoma who underwent surgery between January 1, 2010, and December 31, 2020, and who are being followed until January 1, 2022. Patients were selected if they met the following criteria: they were at least 18 years old, they had a diagnosis of glioblastoma (primary, secondary, or recurrent), they were either IDH mutants or wild types, they had an MRI within 2 weeks before surgery, and they had another MRI within 72 hours after surgery. Before and after surgery, we did a volumetric analysis of gadolinium-enhanced T1 MRI scans of the tumour to figure out EOR. Partial resection (PR) is <70%, sub-total resection (STR) is 70-90%, near-total resection (NTR) is 91-99%, and gross total resection (GTR) is >99%. By comparing pre- and post-operative volumes with the EOR, the Kaplan-Meier survival curve and Cox's regression analysis determined the impact of the EOR on survival rates. Many researchers considered a p value of 0.05 or below to be significant.
Results. A total of 86 patients were included in the analysis after being subjected to the criteria used to narrow the pool of potential participants. The average length of time people lived was 15 months. For PR patients, the median survival time was 3 months, for STR patients it was 10 months, and for NTR patients it was 16 months. Patients receiving GTR, on the other hand, had a considerably better outcome, with a median survival time of 36 months. This data demonstrate a direct correlation between EOR and survival rates. It was discovered that EOR improvement affected post-op survival. High EOR patients have a better prognosis for survival. Adjuvant therapy, pre- and post-operative KPS score, pre- and post-operative tumour volume, and gender also contributed significantly to enhanced survival.
Conclusion. Patients with glioblastoma appear to benefit from a more aggressive treatment strategy that combines maximal safe resection with the use of salvage adjuvant therapy. There was a correlation between complete resection (gross total resection) of intracranial GBM and improved survival. Whenever feasible, complete surgical removal of the tumour is recommended.
Factors affecting the experience of joined-up, continuous primary care in the absence of relational continuity: an observational study
Authors: Burch Patrick , Whittaker William , Bower Peter , Checkland Katherine 
Published: September 2023

BackgroundThere is an international trend towards the at-scale provision of primary care services, with such services often provided in different settings by a clinician unfamiliar to the patient. It is often assumed that, in the absence of relational continuity, any competent clinician can deliver joined-up, continuous care if they have access to clinical notes.AimTo explore the factors that affect the potential for providing joined-up, continuous care in a system where care is delivered away from a patient’s regular practice, by a different organisation and set of staff.Design and settingCase studies of two extended-access providers in the north of England.MethodCase studies were carried out between September 2021 and January 2022 in two sites. Data collected included observations of patient–healthcare professional interactions, interviews with staff and patients, and documentation. Analysis took place using a constant comparison approach. Data were coded. A model of the factors affecting continuity was constructed.ResultsThe potential for joined-up, continuous care appears dependent on staff, patient, and system factors. This includes diverse elements such as the attitude of clinicians to care coordination and the ability of an organisation to retain staff.ConclusionHealthcare systems increasingly rely on the assumption that any competent clinician can deliver joined-up, continuous care if they have access to clinical notes. This appears not to be the case. This study presents a model of factors affecting the patient’s experience of continuity. The model needs validating in in-hours general practice and other settings.
METHOD OF ALGEBRAIC SYNTHESIS OF ORTHOGONAL BINARY SEQUENCES FOR DATA TRANSMISSION SYSTEMS WITH CODE DIVISION MULTIPLEXING
Authors: Зеленевский В.В. , Зеленевский Ю.В. , Попов А.В. , Наконечный А.Б. 
Published: September 2023

Разработан метод алгебраического синтеза ортогональных двоичных последовательностей на основе двоичных помехоустойчивых кодов с улучшенными автокорреляционными свойствами и представлена его реализация с параллельным запуском генератора (формирователя) для повышения быстродействия.
A method of algebraic synthesis of orthogonal binary sequences based on binary noise-resistant codes with improved autocorrelation properties and its implementation with the parallel start-up of a generator (shaper) to increase performance has been developed.
GENERATION OF PSEUDO-RANDOM BIT SEQUENCES USING EQUATIONS OF DYNAMIC CHAOS THEORY USING THE LORENTZ ATTRACTOR AS AN EXAMPLE
Authors: Лемешко Н.В. , Захарова С.С. 
Published: September 2023

Предложен подход к формированию псевдослучайных битовых последовательностей на основе уравнения, в котором был обнаружен аттрактор Лоренца. Рассмотрены основные свойства соответствующей системы дифференциальных уравнений, решение которой даёт три функции шумового характера. На основе этого могут быть сформированы псевдошумовые сигналы, которые можно использовать для генерации ПСП. Для этого предложен специальный алгоритм.
The article proposes an approach to the formation of pseudo-random bit sequences (RBS) based on the equation in which the Lorentz attractor was discovered. The main properties of the corresponding system of differential equations are considered, the solution of which gives three noise functions. Based on this, pseudo noise signals can be generated, which can be used to generate the RBS. A special algorithm is proposed for this.
IMPLEMENTATION OF A COMPLETE SYSTEMATIC LAND REGISTRATION POLICY BASED ON COMMUNITY PARTICIPATION IN BALANGAN REGENCY
Authors: Didik Prasetyo Widiyanto  , Muslih Amberi  
Published: September 2023

This study aims to examine the implementation of a complete systematic land registration policy based on community participation (PTSL-PM) in Balangan District, South Kalimantan Province. The research method used is a qualitative research method with a descriptive approach, while data collection techniques are through interviews, observation and documentation. The analysis technique used is the model from Mazmanian and Sabatier. Meanwhile, the extent to which the Balangan district community is involved in supporting PTSL-PM activities is analyzed using Arnstein's concept of the eight steps of community participation. The results of the study show that the influential variables according to this theory have indirectly been identified, analyzed and searched for a solution strategy in its implementation so that PTSL-PM activities in Balangan district can meet the number of predetermined physical and financial completion targets. In addition, the involvement and participation of the Balangan Regency community members which is one of the advantages of PTSL-PM activities in Balangan Regency is in degrees of tokenism and is included in the fifth Placation ladder. In this position the expected form of community participation still requires intensive assistance from the Balangan District Land Office Team.
Keywords: Policy Implementation, Community Participation, Land Registration, PTSL-PM
PENGARUH KIRIGAMI TERHADAP KEMAMPUAN MOTORIK HALUS ANAK KELOMPOK B3 TK ISLAM NU KOTA PALANGKA RAYA TAHUN AJARAN 2019/2020
Authors: Adminpintarharati  
Published: September 2023

ABSTRAK
Motorik halus adalah pengorganisasian penggunakaan otot-otot kecil seperti jari jemari dan tangan, keterampilan yang mencangkup pemanfaatan menggunakan alat-alat untuk mengerjakan suatu objek. Manfaat kegiatan kirigami untuk mengembangkan keterampilan motorik halus seperti menggerakan jari-jemari anak, koordinasi mata dan tangan, dan konsentrasi melalui beberapa teknik dalam membuat kirigami yaitu melipat kertas origami, membuat pola garis dan menggunting. Penelitian ini melibatkan 22 anak pada kelompok B3 TK Islam NU Kota Palangka Raya.Pengumpulan data menggunakan observasi dalam bentuk penilaian, dan dokumentasi serta dianalisis dengan teknik statistik uji-t.Tujuan dari penelitian ini untuk mengetahui pengaruh kirigami terhadap kemampuan motorik halus anak. Hasil penelitian diperoleh dari perhitungan uji-t dengan nilai sebesar 13,28 dibandingkan dengan taraf signifikasi 5% dengan dk = N-1 = 21 maka nilai adalah 2,080, yang berarti (13,28) > (2,080). Berdasarkan hasil tersebut maka ditolak dan diterima.Artinya terdapat pengaruh kirigami terhadap kemampuan motorik halus anak kelompok B3 di TK Islam NU Kota Palangka Raya Tahun Ajaran 2019/2020.

Kata Kunci: Motorik Halus, Kirigami, Anak Usia Dini
STUDI PELAKSANAAN PEMBELAJARAN ANAK USIA DINI DI MASA PANDEMI COVID 19 DI NANGA BULIK KABUPATEN LAMANDAU TAHUN AJARAN 2020/2021
Authors: Adminpintarharati  
Published: September 2023

ABSTRAK
Pendidikan Anak Usia Dini adalah salah satu upaya pembinaan yang ditujukan kepada anak sejak lahir sampai usia enam tahun, yang dilakukan melaui pemberian rangsangan pendidikan untuk membantu pertumbuhan dan perkembangan jasmani dan rohani agar anak memiliki kesiapan dalam memasuki pendidikan lebih lanjut. Pembelajaran bagi anak dilaksanakan di dalam kelas dengan guru sebagai pengajarnya. Namun dalam kondisi pandemi Covid-19 ini anak diharuskan belajar dari rumah saja dan pembelajaran bisa dilakukan secara daring (dalam jaringan) atau online, atau secara luring (luar jaringan) atau offline misalnya dengan kunjungan rumah.
Penelitian ini merupakan penelitian kualitatif menggunakan triangulasi sumber, yaitu guru, orang tua, dan anak. Penelitian ini dilakukan untuk mengetahui pelaksanaan pembelajaran bagi anak usia dini selama pandemi baik dukungan maupun yang dihadapi selama proses pembelajaran di masa pandemi ini. Penelitian ini dilakukan pada guru dari dua TK yang berbeda, orang tua anak, dan anak, dengan pengambilan data dilakukan dengan : angket, wawancara, observasi.
Hasil penelitian menunjukkan bahwa pembelajaran dapat terlaksana dengan baik sesuai dengan perencanaan pembelajaran yang dituangkan dalam RPPH yang sudah disesuaikan dengan kondisi masa pandemi, TKN Pembina melaksanakan pembelajaran secara kombinasi antara daring dan kunjungan ke rumah, sedangkan TK Melati melaksanakan pembelajaran secara daring, dan juga kunjungan ke rumah bagi anak yang tidak mengumpulkan tugasnya. Hambatan yang dihadapi pada pembelajaran yaitu pada jaringan internet yang kurang baik, ketersediaan paket data internet, kurangnya minat anak belajar, ada orang tua yang awalnya menggunakan handphone non android, orang tua yang sulit membagikan waktunya mendampingi anak belajar, kemampuana orang tua dalam membimbing anak belajar yang masih kurang, keterbatasan media pembelajaran, cuaca yang kurang mendukung pada saat kunjungan ke rumah, dan adanya rasa kekhawatiran terhadap penyebaran Covid-19. Sedangkan dukungan dalam pelaksanaan pembelajaran yaitu semangat guru dan orang tua yang cukup tinggi, adanya tenggang waktu yang cukup petunjuk yang jelas dalam pembelajaran dan penyelesaian tugas anak, serta adanya bantuan dari pemerintah berupa buku, alat tulis, fasilitas wifi, serta dana BOP dari Pusat.

Kata Kunci: Pembelajaran, Covid 19, Anak Usia Dini.
PENGARUH MENGGAMBAR BEBAS TERHADAP KREATIVITAS ANAK KELOMPOK B DI TK GARING TARANTANG DESA TUMBANG MANGGU KABUPATEN KATINGAN
Authors: Adminpintarharati  
Published: September 2023

Menggambar bebas merupakan kegiatan menggambar yang memberikan kebebasan seluas-luasnya kepada anak dalam menggambar sesuai dengan imajinasi anak dan merupakan perwujudan ungkapan perasaan tertentu. Kreativitas merupakan kemampuan seseorang untuk menciptakan suatu hal baru, mengubah, atau memodifikasi sesuatu yang pernah ada sebelumnya sehingga menghasilkan sesuatu yang unik. Berdasarkan pengamatan yang dilakukan di TK Garing Tarantang Desa Tumbang Manggu bahwa kreativitas anak usia 5-6 tahun di TK Garing Tarantang Desa Tumbang Manggu masih rendah. Dengan menggambar bebas diharapkan kreativitas anak akan meningkat menjadi lebih baik lagi.
Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh kegiatan menggambar bebas terhadap kreativitas anak usia 5-6 tahun di TK Garing Tarantang Desa Tumbang Manggu. Penelitian adalah penelitian kuantitatif dengan menggunakan metode eksperimen. Instrumen dalam penelitian ini menggunakan lembar observasi. Observasi dilakukan sebanyak 2 kali yaitu sebelum treatment (pre-test) dan sesudah treatment (post-test). Dari pembandingan total skor pada pre-test dan post-test, terdapat peningkatan skor pada post test, yaitu dari skor 122 pada pre-test menjdi 159 pada post test
Kemudian data hasil penelitian tersebut diuji menggunakan uji-t, diperoleh bahwa sebesar 9,880 sedangkan dengan taraf signifikan 5% (0,05) dan d.b = N-1 = 16-1 = 15 adalah sebesar 2,131. Dengan demikian (9,880) > (2,131). Sehingga dapat disimpulkan bahwa Ho ditolak dan Ha diterima berarti terdapat pengaruh kegiatan menggambar bebas terhadap kreativitas anak kelompok B TK Garing Tarantang Desa Tumbang Manggu.

Kata kunci: Menggambar bebas, kreativitas, anak usia dini, TK
Desarrollo de Competencias y Compromiso Escolar: Una Mirada desde la Diversidad en el Aula
Authors: Montañez Albarracín Julie Maitreya , Castro Salazar Magret 
Published: September 2023

El presente escrito reflexivo centra sus intereses en la consideración de la diversidad en el aula como una de las características inherentes, en donde resulta fundamental que pese al abordaje de discapacidades o de otras particularidades, se priorice el desarrollo de variables favorecedoras del proceso educativo. Partiendo del análisis de concepciones de autores como Núñez, Quijano, Zompero, Monje y Shernoff, entre otros; se resalta la importancia de tener en cuenta a las competencias y al compromiso escolar, como dos de los elementos trascendentes en la educación que tiene lugar en el aula diversa y que debe atender a todas las dimensiones del ser humano. El artículo pretende movilizar al lector hacia la visión más holística de la diversidad en la educación, dejando de lado la perspectiva reduccionista de la misma y motivando hacia el despliegue de estrategias que optimicen el proceso de formación del estudiante y que consideren tanto al compromiso escolar como a las competencias que trascienden de lo cognitivo, como fundamentales en este.
Probing the Conditions for the H i-to-H2 Transition in the Interstellar Medium
Authors: Park Gyueun , Lee Min-Young , Bialy Shmuel , Burkhart Blakesley , Dawson J. R. , Heiles Carl , Li Di , Murray Claire , Nguyen Hiep , Hafner Anita , Rybarczyk Daniel R. , Stanimirović Snežana 
Published: September 2023

Abstract
We investigate the conditions for the H i-to-H2 transition in the solar neighborhood by analyzing H i emission and absorption measurements toward 58 Galactic lines of sight (LOSs) along with 12CO(1–0) (CO) and dust data. Based on the accurate column densities of the cold and warm neutral medium (CNM and WNM), we first perform a decomposition of gas into atomic and molecular phases, and show that the observed LOSs are mostly H i-dominated. In addition, we find that the CO-dark H2, not the optically thick H i, is a major ingredient of the dark gas in the solar neighborhood. To examine the conditions for the formation of CO-bright molecular gas, we analyze the kinematic association between H i and CO, and find that the CNM is kinematically more closely associated with CO than the WNM. When CNM components within CO line widths are isolated, we find the following characteristics: spin temperature < 200 K, peak optical depth > 0.1, CNM fraction of ∼0.6, and V-band dust extinction > 0.5 mag. These results suggest that CO-bright molecular gas preferentially forms in environments with high column densities where the CNM becomes colder and more abundant. Finally, we confront the observed CNM properties with the steady-state H2 formation model of Sternberg et al. and infer that the CNM must be clumpy with a small volume filling factor. Another possibility would be that missing processes in the model, such as cosmic-rays and gas dynamics, play an important role in the H i-to-H2 transition.
The Relationship between IGM Lyα Opacity and Galaxy Density near the End of Reionization
Authors: Christenson Holly M. , Becker George D. , D’Aloisio Anson , Davies Frederick B. , Zhu Yongda , Boera Elisa , Nasir Fahad , Furlanetto Steven R. , Malkan Matthew A. 
Published: September 2023

Abstract
Observed scatter in the Lyα opacity of quasar sightlines at z < 6 has motivated measurements of the correlation between Lyα opacity and galaxy density, as models that predict this scatter make strong and sometimes opposite predictions for how they should be related. Our previous work associated two highly opaque Lyα troughs at z ∼ 5.7 with a deficit of Lyα emitting galaxies (LAEs). In this work, we survey two of the most highly transmissive lines of sight at this redshift toward the z = 6.02 quasar SDSS J1306+0356 and the z = 6.17 quasar PSO J359-06. We find that both fields are underdense in LAEs within 10 h
−1 Mpc of the quasar sightline, somewhat less extensive than underdensities associated with Lyα troughs. We combine our observations with three additional fields from the literature and find that while fields with extreme opacities are generally underdense, moderate opacities span a wider density range. The results at high opacities are consistent with models that invoke UV background fluctuations and/or late reionization to explain the observed scatter in intergalactic medium (IGM) Lyα opacities. There is tension at low opacities, however, as the models tend to associate lower IGM Lyα opacities with higher densities. Although the number of fields surveyed is still small, the low-opacity results may support a scenario in which the ionizing background in low-density regions increases more rapidly than some models suggest after becoming ionized. Elevated gas temperatures from recent reionization may also be making these regions more transparent.
Small Region, Big Impact: Highly Anisotropic Lyman-continuum Escape from a Compact Starburst Region with Extreme Physical Properties
Authors: Kim Keunho J. , Bayliss Matthew B. , Rigby Jane R. , Gladders Michael D. , Chisholm John , Sharon Keren , Dahle Håkon , Rivera-Thorsen T. Emil , Florian Michael K. , Khullar Gourav , Mahler Guillaume , Mainali Ramesh , Napier Kate A. , Navarre Alexander , Owens M. Riley , Roberson Joshua 
Published: September 2023

Abstract
Extreme, young stellar populations are considered to be the primary contributor to cosmic reionization. How the Lyman continuum (LyC) escapes these galaxies remains highly elusive, and it is challenging to observe this process in actual LyC emitters without resolving the relevant physical scales. We investigate the Sunburst Arc, a strongly lensed LyC emitter at z = 2.37 that reveals an exceptionally small-scale (tens of parsecs) region of high LyC escape. The small (<100 pc) LyC-leaking region has extreme properties: a very blue UV slope (β = −2.9 ± 0.1), a high ionization state ([O iii] λ5007/[O ii] λ3727 = 11 ± 3 and [O iii] λ5007/Hβ = 6.8 ± 0.4), strong oxygen emission (EW([O iii]) = 1095 ± 40 Å), and a high Lyα escape fraction (0.3 ± 0.03), none of which are found in nonleaking regions of the galaxy. The leaking region’s UV slope is consistent with approximately “pure” stellar light that is minimally contaminated by the surrounding nebular continuum emission or extinguished by dust. These results suggest a highly anisotropic LyC escape process such that LyC is produced and escapes from a small, extreme starburst region where the stellar feedback from an ionizing star cluster creates one or more “pencil-beam” channels in the surrounding gas through which LyC can directly escape. Such anisotropic escape processes imply that random sight-line effects drive the significant scatters between measurements of galaxy properties and LyC escape fraction, and that strong lensing is a critical tool for resolving the processes that regulate the ionizing budget of galaxies for reionization.
Gear Up for the Action Replay: Leveraging Lensing for Enhanced Gravitational-wave Early Warning
Authors: Magare Sourabh , Kapadia Shasvath J. , More Anupreeta , Singh Mukesh Kumar , Ajith Parameswaran , Ramprakash A. N. 
Published: September 2023

Abstract
Premerger gravitational-wave (GW) sky localization of binary neutron star (BNS) and neutron star–black hole (NSBH) coalescence events would enable telescopes to capture precursors and electromagnetic (EM) emissions around the time of the merger. We propose an astrophysical scenario that could provide early-warning times of hours to days before coalescence with subarcsecond localization, provided that these events are gravitationally lensed. The key idea is that if the BNS/NSBH is lensed, then so is the host galaxy identified via the EM counterpart. From the angular separation of the lensed host galaxy images, as well as its redshift and the (foreground) lens redshift, we demonstrate that, for galaxy-scale lenses, we can predict the time delays/arrival time differences assuming a standard lens model. We further assess the feasibility and benefits of lensing as a tool for early warning in various GW observing runs of the LIGO–Virgo–Kagra network, including Voyager and the third-generation network. To that end, we study the effect of the limited angular resolution of the telescopes on our ability to predict the time delays. We find that with an angular resolution of 0.05″ we can predict time delays of >1 day with 1σ error bar of

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(hours) at best. We also construct realistic time delay distributions of detectable lensed BNSs/NSBHs to forecast the early-warning times we might expect in the observing scenarios we consider.