bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetics, pharmacodynamics and safety of the novel C‐X‐C chemokine receptor 3 antagonist ACT‐777991: Results from the first‐in‐human study in healthy adults
Authors: Boof Marie‐Laure , Géhin Martine , Voors‐Pette Christine , Hsin Chih‐Hsuan , Sippel Virginie , Strasser Daniel S. , Dingemanse Jasper 
Published: September 2023

AimsThe C‐X‐C chemokine receptor 3 (CXCR3) axis is highly upregulated in the tissue of patients with type 1 diabetes. Antagonizing CXCR3 may reduce the migration of CXCR3‐expressing cells to the pancreas. The pharmacokinetics (PKs), target engagement (TE) (inhibition of CXCR3 internalization) and safety of single‐ and multiple‐ascending doses (SADs and MADs) of ACT‐777991, a novel orally available potent CXCR3 antagonist, were assessed in a double‐blind, randomized, placebo‐controlled phase 1 study.MethodsDoses up to 100 mg (SAD part) and 40 mg twice daily (MAD part) were investigated in a total of 70 male and female healthy participants. Food effect was integrated as an SAD subpart. PK, TE, safety and tolerability data were collected up to 4 days after (last) dosing.ResultsIn both SAD and MAD parts, ACT‐777991 was rapidly absorbed with a time to reach maximum concentration between 0.5 and 1.5 h post dose, followed by a biphasic disposition with a terminal half‐life between 9.7 and 10.3 h. Increase in exposure and maximum concentration of ACT‐777991 were dose‐proportional. Steady state was reached after 48 h with minimal accumulation. The rate but not the extent of absorption was modified by food intake. A dose‐dependent TE was demonstrated in both SAD and MAD parts. ACT‐777991 was well tolerated. Neither a treatment‐related pattern nor a dose‐response relationship was determined for adverse events or any safety variable. No QT prolongation liability of regulatory concern was detected.ConclusionsIn this first‐in‐human study, ACT‐777991 showed good tolerability for all doses tested and a PK and TE profile suitable for further clinical development.
How did corporate responses to the Covid‐19 pandemic correspond with CSR?
Authors: Martinez Fabien , Figge Frank , Castellano Sylvaine , Chakraborty Atreya , Silva‐Gao Lucia 
Published: September 2023

AbstractThis editorial of the special issue addresses the question of whether/how responses to the Covid‐19 pandemic corresponded with authentic CSR. The literature on CSR has tended to endorse a business‐centric perspective and its inherent focus on the search for alignments between CSR activities and the economic/financial interests of the firm. The Covid‐19 pandemic has put this perspective to the test, pushing many companies to engage in distinctively more genuine and authentic CSR and/or demonstrating the importance of prior CSR engagement in facilitating crisis management. The papers included in the special issue appear to converge on the idea that firms combining evidence of both pre‐crisis engagement in CSR and strong CSR performance during the crisis (demonstrated through the deployment of various CSR assets and resources, including certified reporting, social marketing, individual engagement, resilience, legitimacy, trust) have coped better. This provides interested researchers with an opportunity to appreciate the value of CSR during a crisis.
Design Innovation in Nonprofits: A Need for New Design Strategies
Authors: Borra Luisella , Boult John 
Published: September 2023

Nonprofits have been slow to welcome design into their organizations. However, nonprofits operate in the same fast‐paced environment as do for‐profit companies, and design can be just as helpful for them in plotting a new and improved course toward more aid for the recipients of their generosity.Nonprofits are slowly discovering the innovation benefits of design.
Prognostic value of early electrographic biomarkers of epileptogenesis in high‐risk ischaemic stroke patients
Authors: Tatillo Chiara , Legros Benjamin , Depondt Chantal , Rikir Estelle , Naeije Gilles , Jodaïtis Lise , Ligot Noémie , Gaspard Nicolas 
Published: September 2023

AbstractBackground and purposePost‐stroke epilepsy (PSE) is frequent. Better prediction of PSE would enable individualized management and improve trial design for epilepsy prevention. The aim was to assess the complementary value of continuous electroencephalography (EEG) data during the acute phase compared with clinical risk factors currently used to predict PSE.MethodsA prospective cohort of 81 patients with ischaemic stroke who received early continuous EEG monitoring was studied to assess the association of early EEG seizures, other highly epileptogenic rhythmic and periodic patterns, and regional attenuation without delta (RAWOD, an EEG pattern of stroke severity) with PSE. Clinical risk factors were investigated using the SeLECT (stroke severity; large‐artery atherosclerosis; early clinical seizures; cortical involvement; territory of middle cerebral artery) scores.ResultsTwelve (15%) patients developed PSE. The presence of any of the investigated patterns was associated with a risk of epilepsy of 46%, with a sensitivity and specificity of 83% and 78%. The association remained significant after adjusting for the SeLECT score (odds ratio 18.8, interquartile range 3.8–72.7).ConclusionsIt was found that highly epileptogenic rhythmic and periodic patterns and RAWOD were associated with the development of PSE and complemented clinical risk factors. These findings indicate that continuous EEG provides useful information to determine patients at higher risk of developing PSE and could help individualize care.
Punished and banished: Non‐citizen women's experiences in a Danish prison
Authors: Damsa Dorina 
Published: September 2023

AbstractThe Nordics have employed discourses of gender equality and women's rights and a welfare‐oriented approach to punishment as integral parts of inclusive welfare states and their ‘goodness’. Drawing on ethnographic fieldwork with non‐citizen women at Vestre Prison in Denmark, this article suggests that the will to punish and banish prevails over the state's commitment to women's rights and protection. Rather than being an inherent feature of incarceration, the pain experienced by non‐citizen women in prison is a ‘political statement’ (Bosworth, 2023). Employing precarisation, incarceration and deportation to govern unwanted non‐citizens and (re)produce the borders of membership, the Danish state also reproduces the conditions for gendered harm. Bordered penality, this article concludes, is gendered.
Photodynamic therapy adjuvant to non‐surgical periodontal therapy: Systematic review of randomized clinical trials
Authors: Souza Daniel Adrian Silva , de Lima Dantas Juliana Borges , Souto Camila Silva , Mendonça Dina Marques , Oliveira Tiago José Silva , dos Santos Vianna Néri Júlia 
Published: September 2023

AbstractObjectivesTo systematically evaluate randomised controlled trials (RCTs) on whether adjuvant application of antimicrobial photodynamic therapy (aPDT) through the technique of irradiation in the external region of the periodontal pocket with optic‐fibre tip offers benefits to scaling and root planning (SRP).MethodsFive databases were searched by two independent reviewers according to pre‐specified eligibility criteria up to April 2023. No restrictions regarding date of publication, language and minimum follow‐up period were imposed. The Cochrane Collaboration's Risk of Bias tool (RoB 2.0) was used for quality appraisal and Grading of Recommendations, Assessment, Development and Evaluation for assessing the certainty of evidence.ResultsA total of 1388 publications were identified and reviewed for eligibility. Four of them fulfilled the inclusion criteria. The sample consisted of a total of 83 patients with periodontitis. In these, 330 periodontal sites were evaluated. The clinical findings of the majority of the included studies demonstrated that patients who received the association of aPDT + RAR with the protocol evaluated here, obtained clinical results similar to patients who received only the SRP alone. In none of the evaluated RCTs, clinical advantages were observed that would categorise this aPDT protocol as superior to conventional treatment.ConclusionApplying aPDT after SRP with external irradiation of the periodontal pocket does not seem to result in any clinical benefit compared to the use of SRP alone in patients with periodontitis.
A case–control study addressing the population of epidermal and dermal inflammatory infiltrate including neural milieu in primary prurigo nodularis using S‐100 and toluidine blue stain and its therapeutic implications
Authors: Agrawal Diksha , Sardana Kabir , Mathachan Sinu Rose , Bhardwaj Minakshi , Ahuja Arvind , Jain Swasti , Panesar Sanjeet 
Published: September 2023

AbstractBackgroundThe pathogenesis of prurigo nodularis (PN) is considered to be multifactorial, with numerous cells and cytokines confabulating to produce an aberrant immune response.MethodsA cross‐sectional observational study was done in cases of untreated primary prurigo nodularis cases with histopathological assessment in 49 cases from lesional and nonlesional skin with assessment of epidermal and dermal changes, dermal infiltrate, S‐100 and toluidine blue staining to assess the expression of nerve and mast cells.ResultsThe most common histological changes seen in lesional skin were hyperkeratosis (98%), irregular hyperplasia (69.4%), hypergranulosis (69.4%), subepidermal clefting (6%), vertical collagen bundles (51.0%), and dermal fibrosis (48.9%). Chronic inflammatory infiltrate was seen in all cases (100%) predominantly of lymphocytes (100%) followed by eosinophils (18.4%), plasma cells (8.2%), and neutrophils (2.0%). There was a marked increase in the expression of S‐100 (6.92 ± 3.40 vs. 3.94 ± 2.15, P < 0.001) and toluidine blue (4.99 ± 4.47 vs. 1.22 ± 1.28, P < 0.001) in the lesional skin as compared to the nonlesional skin.ConclusionWe can infer that the epidermal and dermal pathology in PN is related to the infiltrate of lymphocytes, mast cells, and neural hyperplasia which perpetuate the pathogenesis by triggering the itch‐inflammation cycle. Thus, apart from immunosuppressive agents that target lymphocytes and their cytokines, therapy targeted at mast cells and neural proliferation may be needed to treat prurigo nodularis.
Suppression of protein quality control system by TRIM30a sensitises tumour cells to NK cell‐mediated immune surveillance
Authors: Afolabi Lukman O. , Bi Jiacheng , Chen Liang , Yang Xiaolu , Wan Xiaochun 
Published: September 2023

AbstractTumorigenesis entails circumventing cell‐intrinsic regulatory mechanisms while avoiding extrinsic immune surveillance and other host defence systems. Nevertheless, how tumour cells' ability to eliminate misfolded proteins affects immune surveillance remains poorly understood. In this study, we find that overexpression of murine tripartite motif‐containing protein 30a (TRIM30a) sensitises tumour cells to natural killer (NK) cells‐mediated cytolysis. TRIM30a has no effect on tumour cell proliferation or apoptosis in vitro. However, TRIM30a‐overexpressing tumour cells grow substantially slower than control tumour cells in immune‐competent mice but not in NK cell‐depleted mice. [Correction added on 04 October 2023, after first online publication: ‘NK‐depleted’ has been changed to ‘NK cell‐depleted’ in the preceding sentence.] Mechanistically, TRIM30a overexpression impedes the clearance of misfolded proteins and increases the production of reactive oxygen species induced by proteotoxic stress, implying that TRIM30a impairs protein quality control (PQC) systems in tumour cells. Furthermore, TRIM30a reduces expression of genes encoding proteasome subunits and antioxidant proteins. Our study demonstrates that TRIM30a is a potential tumour suppressor and immune modulator that promotes tumour cytolysis by NK cells, and suggests that an enhanced PQC and antioxidant capacity is an integral part of the immune escape mechanism during tumorigenesis.
Fathers' experiences of living with a child with a progressive life‐limiting condition without curative treatment options: A qualitative systematic review
Authors: Sjuls Marianne , Ludvigsen Mette Spliid , Robstad Nastasja , Fegran Liv 
Published: September 2023

AbstractAimTo systematically review and synthesize findings across qualitative primary studies about fathers' experiences of living with a child with a progressive life‐limiting condition without curative treatment options (C3 conditions).DesignSystematic review and metasynthesis.MethodsSandelowski and Barosso's qualitative research methodology guided this review and metasynthesis. A modification of Ricoeur's interpretation theory, described by Lindseth and Norberg, guided the synthesis of qualitative data. The quality of the studies was evaluated using the Joanna Briggs Institute Checklist for Qualitative Research.Data SourcesA systematic literature search was conducted on 6 May 2022 and updated on 19 July 2023 on MEDLINE, CINAHL Plus with Full Text, APA PsycInfo and Scopus. Inclusion criteria were English‐written qualitative studies from the year 2000, from which we could extract data on fathers' experiences of living with a child from 0 to 18 years with a progressive life‐limiting condition without curative treatment options.ResultsSeven reports from Western countries contributed to the review. Through structural analysis, we developed the following themes: ‘Being shattered in the perception of fatherhood’, ‘Establishing a new normal’ and ‘Striving to be acknowledged as a part of the caring team’.ConclusionFathers had to establish a new normal, and they experienced anticipatory mourning, role conflicts and feeling sidelined in healthcare settings when living with a child with a C3 condition. An important issue for further research on paediatric palliative care (PPC) should be to include fathers in the research sample and report separately on fathers' or mothers' experiences instead of parents' experiences.ImpactThe findings will be of interest to healthcare personnel and multidisciplinary teams working within PPC, as they give insight into fathers' experiences and suggest interventions to increase healthcare personnel's involvement with fathers, such as telemedicine.Reporting MethodFollowing EQUATOR guidelines, the study was reported according to the enhancing transparency in reporting the synthesis of qualitative research (ENTREQ) framework.Patient or Public ContributionNo patient or Public Contribution.
Tangible digital collaborative storytelling in adolescents with intellectual disability and neurodevelopmental disorders
Authors: Alonso‐Campuzano Cristina , Iandolo Giuseppe , Filosofi Fabio , Tardivo Angela , Sosa‐González Noelia , Pasqualotto Angela , Venuti Paola 
Published: September 2023

AbstractBackgroundCollaborative storytelling can be a helpful tool to promote cognitive and social skills in adolescents with neurodevelopmental disorders.AimsThe current study aimed to explore the benefits of collaborative storytelling using traditional (TST), digital (DST), and tangible digital (TDST) methodologies.Materials and MethodsFourteen Spanish students with mild to moderate intellectual disability and other neurodevelopmental comorbid disorders participated in collaborative storytelling sessions in the classroom, following an experimental, mixed, and cross‐sectional design. The study comprised three individual assessments of narrative skills and eight collaborative storytelling sessions using different storytelling methodologies. Individual and collaborative stories were videotaped, transcribed verbatim, and analysed for formal and content characteristics. Behaviours and interactions during the collaborative storytelling were analysed for each group and session.ResultsThe results show a positive effect of collaboration on students' stories, compared to individual performance, regardless of the methodology used.ConclusionCollaboration, technological device handling, and shared storytelling did not present a barrier for the participants.
Middle childhood development in personal values
Authors: Daniel Ella , Misgav Kinneret , Chomsky Anat 
Published: September 2023

AbstractObjectiveWe aimed to investigate value change and stability longitudinally in middle childhood.BackgroundValues are the aspect of personality defining one's aspirations. Research identifies meaningful values in middle childhood, yet we know little about the process of their development within individual.MethodChildren (N = 298; 53.7% girls, Mage = 7 years and 3 months, SD = 7.70 months, at the first time point) four times, annually.ResultsRank‐order stability increased with age and decreased with time‐span. We found value hierarchy consistency, with value hierarchy similar to adolescents in the priority given to openness to change versus conservation values, and to adults in the priority given to self‐transcendence values. Latent growth curve analyses indicated linear increase in openness to change, and curvilinear increase in self‐transcendence values, and linear decrease in conservation and self‐enhancement values, with some differences across ages. Value structure was better differentiated with age. Compatible values changed in similar, and conflicting values in opposite directions.ConclusionsThis paper suggests that in middle childhood, children can already report stable values. Moreover, middle childhood is characterized by coherent change patterns, of increase in the importance of growth, and decrease in the focus on conflicting protection values.
Grass pollen surface ornamentation is diverse across the phylogeny: Evidence from northern South America and the global literature
Authors: Wei Cai‐Xia , Jardine Phillip E. , Mao Li‐Mi , Mander Luke , Li Mao , Gosling William D. , Hoorn Carina 
Published: September 2023

AbstractThe grasses are one of the most diverse plant families on Earth. However, their classification and evolutionary history are obscured by their pollen stenopalynous (similar) morphology. A combination of high‐resolution imaging of pollen surface ornamentation and computational analysis has previously been proposed as a promising tool to classify grass taxonomic boundaries. In this study, we test this hypothesis by studying Poaceae pollen across the phylogeny from plants collected in northern South America and also from published literature across the globe. We assessed if morphotypes that we establish using descriptive terminology are supported by computational analysis, if they vary along six (a)biotic variables and vary across the phylogeny. Based on this analysis, we constructed a reference framework for pollen surface ornamentation morphotypes. Our results showed that there is a wide variation of grass pollen surface ornamentation. We identified nine new and confirmed six known morphotypes, establishing a data set for 223 species (243 individual plant specimens) that represent 11 subfamilies. Computational analysis showed that our morphotypes are well‐supported by two quantitative features of pollen sculptural elements (size and density). The specific data set and mapping of the phylogeny confirmed that pollen morphological sculpture is unrelated to (a)biotic variables and is diverse across the phylogeny.
Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection
Authors: Pelizzaro Filippo , Trevisani Franco , Simeon Vittorio , Vitale Alessandro , Cillo Umberto , Piscaglia Fabio , Missale Gabriele , Sangiovanni Angelo , Foschi Francesco G. , Cabibbo Giuseppe , Caturelli Eugenio , Di Marco Maria , Azzaroli Francesco , Brunetto Maurizia R. , Raimondo Giovanni , Vidili Gianpaolo , Guarino Maria , Gasbarrini Antonio , Campani Claudia , Svegliati‐Baroni Gianluca , Giannini Edoardo G. , Mega Andrea , Masotto Alberto , Rapaccini Gian Ludovico , Magalotti Donatella , Sacco Rodolfo , Nardone Gerardo , Farinati Fabio ,   for the Italian Liver Cancer (ITA.LI.CA) group
Published: September 2023

AbstractBackground and AimsHepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.MethodsFrom the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC <4 and ≥4 cm.ResultsDuring a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p < 0.001) and overall (44.4% vs. 25.2%; p < 0.001). Similar results were found considering recurrence beyond up‐to‐seven criteria. Compared to those with larger tumours, patients with HCC <4 cm had a longer recurrence‐free survival and overall survival. HCC size ≥4 cm and high alpha‐fetoprotein (AFP) level at the time of LR were independent predictors of recurrence beyond MC (and up‐to‐seven criteria). In the subgroup of patients with available histologic information (n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.ConclusionsDespite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.
Superiority of the new sex‐adjusted models to remove the female disadvantage restoring equity in liver transplant allocation
Authors: Marrone Giuseppe , Giannelli Valerio , Agnes Salvatore , Avolio Alfonso Wolfango , Baiocchi Leonardo , Berardi Giammauro , Ettorre Giuseppe Maria , Ferri Flaminia , Corradini Stefano Ginanni , Grieco Antonio , Guglielmo Nicola , Lenci Ilaria , Lionetti Raffaella , Mennini Gianluca , Milana Martina , Rossi Massimo , Spoletini Gabriele , Tisone Giuseppe , Manzia Tommaso Maria , Lai Quirino 
Published: September 2023

AbstractBackground and AimsModel for End‐stage Liver Disease (MELD) and MELDNa are used worldwide to guide graft allocation in liver transplantation (LT). Evidence exists that females are penalized in the present allocation systems. Recently, new sex‐adjusted scores have been proposed with improved performance respect to MELD and MELDNa. GEMA‐Na, MELD 3.0, and sex‐adjusted MELDNa were developed to improve the 90‐day dropout prediction from the list. The present study aimed at evaluating the accuracy and calibration of these scores in an Italian setting.MethodsThe primary outcome of the present study was the dropout from the list up to 90 days because of death or clinical deterioration. We retrospectively analysed data from 855 adults enlisted for liver transplantation in the Lazio region (Italy) (2012–2018). Ninety‐day prediction of GEMA‐Na, MELD 3.0 and sex‐adjusted MELDNa with respect to MELD and MELDNa was analysed. Brier score and Brier Skill score were used for accuracy, and the Greenwood‐Nam‐D'Agostino test was used to evaluate the calibration of the models.ResultsGEMA‐Na (concordance = .82, 95% CI = .75–.89), MELD 3.0 (concordance = .81, 95% CI = .74–.87) and sex‐adjusted MELDNa (concordance = .81, 95% CI = .74–.88) showed the best 90‐day dropout prediction. GEMA‐Na showed a higher increase in accuracy with respect to MELD (p = .03). No superiority was shown with respect to MELDNa. All the tested scores showed a good calibration of the models. Using GEMA‐Na instead of MELD would potentially save one in nine dropouts and could save one dropout per 285 patients listed.ConclusionsValidation and reclassification of the sex‐adjusted score GEMA‐Na confirm its superiority in predicting short‐term dropout also in an Italian setting when compared with MELD.