bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between an inflammation-based nutritional tool (Glasgow Prognostic Score) and length of hospital stay in patients with haematological cancer
Authors: Song Anqi , Ni Beiwen , Lijing Shen , Molian Tang , Zhou Yiquan , Zhang Xiaomin , Chen Zhiqi , Xu Renying 
Published: June 2023

Abstract

Background
Glasgow Prognostic Score (GPS) is a prognostic tool that combines an inflammatory marker [C-Reactive Protein (CRP)] with a nutritional marker (serum albumin). Yet, there is few published work on the reliability of GPS in patients with haematological cancer.
Methods
This is a retrospective single-centre study. All the participants (n = 1,621) were adult inpatients at Ren Ji Hospital between 2018 and 2022. The GPS (CRP < 10 mg/L and albumin ≥ 35 g/L = 0; CRP ≥ 10 mg/L and albumin < 35 g/L = 2; either CRP ≥ 10 mg/L or albumin < 35 g/L = 1) and a variety of biochemical variables were examined at admission and was obtained by reviewing the medical records. GPS = 0 were classified as low-risk while GPS = 2 as high-risk. Length of hospital stay (LOS) was defined as the interval between the admission and discharge date.
Results
8.8% of patients were high-risk. GPS was associated with LOS (β = 2.7 d; 95% CI: 0.8 d, 4.6 d; p trend < 0.001) after adjustment of sex, age, type of diseases, BMI, alanine aminotransferase, aspartate aminotransferase, total bilirubin, estimated glomerular filtration rate, haemoglobin, red blood cell count, white blood cell count and fasting blood glucose. Each point of GPS was associated with 1.9 days (95% CI: 1.4 d, 2.4 d) longer in LOS with full adjustment. The association was more prominent in younger patients (< 65 y), patients with leukaemia and myelodysplastic syndrome, and those with normal body weight status (18.5–24 kg/m2), compared with their counterparts.
Conclusion
GPS was associated with LOS in Chinese patients with haematological cancer, indicating GPS could be a useful assessment tool to predict outcome.
Identification of Diseases caused by non-Synonymous Single Nucleotide Polymorphism using Random Forest and Linear Regression Algorithms
Authors: Anjum Muhammad Junaid , Tariq Fatima , Anjum Khadeeja , Shaheen Momina , Ahmad Faizan 
Published: June 2023

Abstract
The analysis of different types of diseases is an extremal vital task which would help in producing vaccines for that particular type of disease. However, this is a very costly process as to test every disease it would mean to analyze every gene related to that specific disease. This issue of genic analysis is further elevated when different variations of each disease is considered. As such the use of different computational methods is taken into consideration to tackle the task of genic variation identification. This research makes use of Machine Learning algorithms to help in the identification and prediction of Single Nucleotide Polymorphism or more specifically Single Amino Acid Polymorphism. Taking into consideration ten different types of diseases, this research makes use of Random Forest and Linear Regression algorithms to identify and predict different genic variations of these diseases. From the extensive research, this article concludes that Random Forest algorithm performs better in comparison to Linear regression in genic variation predictions.
WY14643, a agonist of PPARα, attenuates HFD-induced AIH by regulating hepatocyte lipid metabolism, necrosis and apoptosis via inhibiting JNK signaling pathway
Authors: Zhao Cuijuan , Zhao Xingliang , Ji Guixian , Li Siyao , Zhou Lu 
Published: June 2023

Abstract
Aim of the study: The regulation molecular mechanism of the occurrence and development of AIH by PPARα and JNK signaling pathway.
Methods: Mice were fed for 16 weeks either on a normal chow diet (ND) consisting of 4.5% fat or a HFD. Mice were intravenously administered Con A (20 mg/kg) to induce the AIH. GW6471 (20 mg/kg) or WY14643 (6 mg/kg) was injected intraperitoneally for 3days. The mice and liver and spleen tissues were weighted. The histopathological analysis was performed by HE staining. The Inflammatory factors IL-1β, IL-6 and TNF-α was detected using ELISA assay. The mRNA and protein levels were detected using RT-qPCR and Western blotting.
Results: HFD could significantly exacerbate the ConA-induced AIH, including liver steatosis, fat accumulation and liver inflammation of mice. Compared with other groups, necroptosis formation and apoptosis-related proteins, which were expressed at abnormally high levels in the liver tissues of HFD + ConA group, were significantly up-regulated by HFD treatment. Therefore, HFD could promote the programmed necrosis and apoptosis in AIH mice. At the same time, HFD could inhibit the expression of PPARα and activate the JNK signaling pathway in AIH mice. Furthermore, PPARα inhibitor GW6471 could further aggravate the necrosis and apoptosis of AIH mice and PPARα agonist WY14643 could alleviate the deterioration of HFD in AIH mice. Importantly, PPARα agonist WY14643 could further alleviate the necrosis and apoptosis of AIH mice through inhibiting the JNK signaling pathway.
Conclusion: Our findings demonstrated that PPARα had the efficacy on inhibiting HFD-induced AIH progression by inhibiting the necrosis and apoptosis of hepatocyte and the lipid metabolism abnormity of liver. Further molecular mechanism study found that WY14643 could upregulate the PPARα and inhibit the function of activating JNK signaling pathway.
Plasma exosomal miR-142-3p induced by acupuncture protects against heart injury in rat with myocardial infarction by targeting Cofilin-2
Authors: Zhao Yue , Wang Ying , Guo Haidong , Guo Chunrong , Sun Qiyu , Lu Pingping , Shen Yang , Shao Shuijin , Lu Rong , Wang Qiangli 
Published: June 2023

Abstract

Purpose
The protective effects of acupuncture on myocardial injury have been identified in clinical trials, but the underlying mechanisms are still not completely understood. This study aimed to investigate the roles of exosomes induced by acupuncture in cardioprotection.
Materials and methods
Masson’s-trichrome staining was used to observe the size of infarcted myocardium region. Western blot was used to detect protein expression. Ultracentrifugation methods were used to isolate plasma exosomes of rats. Small RNA sequencing combined with real-time PCR were performed to analysis expression miRNAs. Bioinformatics-based analysis and dual luciferase reporter assay were used to identify target genes of miRNAs.
Results
Acupuncture thickened the infarct wall of the left ventricle, and inhibited apoptosis of infarcted myocardium by upregulation of Bcl-2 and down-regulation of BAX and cleaved caspase 3. These effects of acupuncture were significantly reversed by inhibiting exosome secretion. Plasma exosomes induced by acupuncture increased the viability of cardiomyocytes in H2O2-induced injury. Five miRNAs from the plasma exosomes were increased by acupuncture, and the unique miRNA (miR-142-3p) among these miRNAs was upregulated in myocardial tissue. These changes in miRNAs induced by acupuncture were similarly inversed when exosome secretion was inhibited by GW4869. Overexpressing miR-142-3p retarded oxidative damage of H9c2 by anti-apoptosis. miR-142-3p directly targeted and downregulated the expression of Cofilin-2 (CFL2). In vivo, CFL2 expression was downregulated in the infarcted myocardium by acupuncture and upregulated by GW4869 injection.
Conclusion
Acupuncture-derived circulating exosomes transfer cardio-protective signals to the injured heart and confer cardioprotective effects, and miR-142-3p is a major exosomal miRNA in the inhibition of myocardial apoptosis by targeting CFL2.
Random packing in three dimensions
Authors: Song Chaoming 
Published: June 2023

Abstract
Unraveling the complexities of random packing in three dimensions has long puzzled physicists. While both experiments and simulations consistently show a maximum density of 64 percent for tightly packed random spheres, we still lack an unambiguous and universally accepted definition of random packing. This paper introduces an innovative standpoint, depicting random packing as spheres closest to a set of quenched random points. We furnish an efficacious algorithm to probe this proposed model numerically. We unearth a unique out-of-equilibrium thermodynamic phenomenon, akin to a ‘latent heat’, that emerges at ϕJ ≈ 0.645 in three dimensions. This phenomenon is accompanied by global and local structural rearrangements, marking a jamming transition from an unjammed state to a jammed one. Notably, such a ‘jamming’ transition is absent for two-dimensional random packing. Our innovative approach paves a new avenue for defining random packing and provides novel insights into the behavior of amorphous materials.
GLP-1 RA treatment improves the secretory function and proliferation of pancreatic β-cells with ABCC8 dysfunction
Authors: Zhang Yan , Xi Yanghua , Wang Jiancheng , Zeng Sha , Chen Cuiyun , Xiao Shengqun , Liu Jianying 
Published: June 2023

Abstract
Purpose: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are used to treat type 2 diabetes, but whether GLP-1 RAs have therapeutic effects on diabetes associated with ABCC8dysfunction remains elusive.
Methods: We created pancreatic MIN6 cells that overexpressed wild-type and mutant ABCC8. We assessed their proliferation using MTT and measured insulin and C-peptide secretion through ELISA. Additionally, we studied the proliferation and insulin/C-peptide secretion of pancreatic β-cells in mice with adeno-associated virus (AAV) carrying wild-type and mutant Abcc8. Furthermore, we investigated the impact of a GLP-1 RA (liraglutide) on the proliferation and secretory function of MIN6 cells and pancreatic β-cells in T1DM mice expressing mutant ABCC8 using ELISA and immunofluorescence.
Results: We found that MIN6 cells that overexpress wild-type ABCC8 secrete more insulin and C-peptide than control cells, while MIN6 cells expressing mutant ABCC8 secrete lower levels of insulin and C-peptide than control cells. In the fasting T1DM mice, overexpression of wild-type ABCC8 accelerated glucose consumption, repressed glucagon level, and elevated insulin and C-peptide secretion. By contrast, overexpression of mutant ABCC8 slightly impaired insulin and C-peptide secretion in MIN6 cells and reduced expression of insulin in the pancreatic β-cells of T1DM mice. In addition, we observed that treatment of MIN6 cells and T1DM mice that overexpress mutant ABCC8 with liraglutide can substantially stimulate the proliferation and secretory function of the affected pancreatic β-cells.
Conclusion: GLP-1 RA is a promising therapeutic option for the treatment of diabetes caused by ABCC8 dysfunction.
A randomized controlled trial of an mHealth intervention for gay and bisexual men’s mental, behavioral, and sexual health in a high-stigma, low-resource context: Project Comunică protocol
Authors: Lelutiu-Weinberger Corina , Filimon Mircea , Hoover Donald , Lixandru Mihai , Hanu Lucian , Dogaru Bogdan , Kovaks Tudor , Fierbinteanu Cristina , Ionescu Florentina , Manu Monica , Maris Alexandra , Pana Elena , Dorobantescu Cristian , Streinu-Cercel Adrian , Pachankis John 
Published: June 2023

Abstract

Background
The World Health Organization (WHO) reported that 80% of new HIV diagnoses in 2014 in Europe occurred in Central and Eastern Europe (CEE). Romania has particularly high HIV incidence, AIDS prevalence, and AIDS-related deaths. HIV incidence today in Romania is largely attributed to sexual contact among gay and bisexual men (GBM). However, homophobic stigma in Romania keeps GBM out of reach of the scant available prevention services and serves as a risk factor for HIV. The Comunică intervention delivers motivational interviewing and cognitive-behavioral therapy skills across eight live text-based counseling sessions. Preliminary evidence suggests that Comunică possesses promise for reducing GBM’s co-occurring mental (e.g., depression), behavioral (e.g., heavy alcohol use), and sexual (e.g., HIV-transmission-risk behavior) health risks in Romania and perhaps other similar high-stigma national contexts. This paper describes a randomized controlled trial (RCT) designed to test the efficacy of Comunică.
Methods
To test Comunică’s efficacy, 305 GBM were randomized to receive Comunică or a content-matched education attention control condition. The control condition consists of eight time-matched educational modules that present information regarding GBM identity development, information about HIV transmission and prevention, the importance of HIV/STI testing and treatment, heavy alcohol use and its associations with HIV-transmission-risk behavior, sexual health communication, finding social support, and creating sexual health goals. Outcomes are measured pre-intervention (baseline), and at 4-, 8-, and 12-month follow-ups. The primary outcome is frequency of condomless anal sex acts with HIV-positive or unknown-status partners outside of the context of one’s own adherent PrEP use or primary partner’s adherent PrEP use or undetectable viral load in the past 30 days at each follow-up. Secondary outcomes include depression, anxiety, suicidal thoughts, heavy alcohol use, and HIV/STI testing; motivational and stigma-related mechanisms of intervention efficacy will also be examined.
Discussion
If found to be efficacious, Comunică presents a scalable platform to provide mental, behavioral, and sexual health support to GBM living in Romania and similar high-stigma, low-resource areas within the CEE region and beyond.
Trial registration
Registered April 11, 2019 to ClinicalTrials.gov Identifier: NCT03912753.
Use of professional home care in persons with spinal cord injury in Switzerland: A cross-sectional study
Authors: Wagner Aylin , Brach Mirjam , Scheel-Sailer Anke , Friedli Manuela , Hund-Georgiadis Margret , Jordan Xavier , Schubert Martin , Gemperli Armin 
Published: June 2023

Abstract
Background
Persons with spinal cord injury (SCI) living in the community often require care. The boundaries between professional home care and informal care are blurred, and it is unclear who the typical user of home care is. The objective of this study was to describe the characteristics of persons with SCI using professional home care in Switzerland, determine the frequency of home care visits, and investigate the association of sociodemographic factors, SCI-specific characteristics, secondary health conditions, and functional independence with the use of home care.
Methods
We used cross-sectional data from the 2017 community survey of the Swiss Spinal Cord Injury Cohort Study (SwiSCI). Out of 3,959 eligible individuals 1294 completed the questionnaire and were included in the analysis (response rate 33%). Using descriptive statistics, differences between home care users and non-users as well as the frequency of home care visits were investigated. The association between sociodemographic factors, SCI-specific characteristics, secondary health conditions, functional independence and the use of home care was analyzed using multivariable logistic regression. Multiple imputation was used to account for missing data.
Results
Of 1,294 participants, 280 (22%) used professional home care. The median hours of professional home care received per week was 6 hours (Q1 = 2, Q3 = 12). More home care was used in persons with lower functional independence (Odds ratio (OR) 0.30 per 10 unit decrease in the Spinal Cord Independence Measure (SCIM-SR), 95%-Confidence interval (CI) 0.24–0.37), fewer secondary health conditions (OR 0.96 per unit SCI-SCS, 95%-CI 0.94–0.99), tetraplegia (OR 2.77, 95%-CI 1.92-4.00), women (OR 2.42, 95%-CI 1.70–3.43), higher age (OR 1.22 per 10 years increase, 95%-CI 1.06–1.39), living alone (OR 2.48, 95%-CI 1.53–4.03), and those receiving support from an informal caregiver (OR 1.88, 95%-CI 1.27–2.77).
Conclusions
This is the first study to examine the use of professional home care from the perspective of persons with SCI in Switzerland. Functional independence was found to be a strong predictor of home care use. The findings showed that professional home care complements informal care and is more likely to be used by individuals with SCI who live alone, have tetraplegia, and are female.
Implementation of Stream Cipher RC4 in the Regime of Quantum Communication with QKD
Authors: Sharma Navneet , Kumar Pravindra , Gautam Kumar 
Published: June 2023

Abstract
This article discusses the process of implementation of RC4 encryption algorithm in the field of Quantum information i.e., Quantum version of classical RC4 approach. Quantum cryptography is the prime member of Quantum information theory. One of the Quantum key distribution (QKD) protocol say BB84 is used to implement classical RC4 in to Quantum regime for secure communication. The Qubit uploader circuit based on classical (binary) bits for initialization of Quantum states is presented. The Qubit uploader circuit is implemented using Toffoli gates to upload four classical bits into three Qubits state. The working of RC4 for
Qubit (Quantum data) is presented with one letter of Devanagari script say :. The process of successful en-
cryption and decryption of message data : with Quantum version of RC4 logic for secure communication is
presented.
Analysis of friction ridge evidence for trace amounts of paracetamol in various pharmaceutical industries by Raman spectroscopy
Authors: Czarnomska Martyna , Lewkowicz Aneta , Pierpaoli Mattia , Gruszczyńska Emilia , Kasprzak Magdalena , Gryczyński Zygmunt , Bojarski Piotr , Steinborn Sławomir , Woźniewski Krzysztof 
Published: June 2023

Abstract

The detection of potentially harmful substances as well as those dangerous to life is a multifaceted challenge. On the one hand, it can directly save lives, on the other hand, it can help and improve the work of the police, increasing effectiveness of the investigation. The research carried out within the framework of this study is primarily aimed at identifying paracetamol in fingerprints, taking into account situations of direct contact of a person with paracetamol chronically or in a single high dose. The identification procedure presented, using Raman spectroscopy, aims to rapidly identify the xenobiotic after ingestion by the person - requires touching the tablet with the fingers, which we can name as touch evidence in forensic science investigation. In addition, the authors focus on the effect of additives present in drugs containing paracetamol as the main active ingredient. The results of the screening obtained will allow us to analyze the composition of drugs in terms of potentially toxic substances and their impact on the physicochemical activity of the active substance itself. The research methodology developed also allows for the quick detection of other substances dangerous to life and health, such as amphetamine, heroin, fentanyl, or morphine. In addition to the preventive function, it is also a new solution in the field of forensic methods.
U-shaped Association Between Mean Platelet Volume And Short-term Survival In Chinese Patients With Heart Failure
Authors: Huang Yuan-lei , Zhou Qi , Zheng Tao 
Published: June 2023

Abstract
Background:
Mean Platelet Volume (MPV) has been proposed as a potential predictor of increased mortality risk at 6 months among Chinese patients with heart failure (HF). However, the current evidence supporting this association is limited.
Methods:
This study aimed to investigate the relationship between MPV and HF short-term survival status. The data was obtained from a publicly accessible HF database in Zigong, Sichuan, and included information on 2008 Chinese patients. Baseline MPV was considered as the exposure while HF short-term survival status was the outcome. Two models, a binary logistic regression model and a two-piecewise linear model, were used to analyze the data.
Results:
The study revealed a U-shaped relationship between MPV and all-cause mortality in HF patients. When MPV levels were less than 9.8, every unit increase in MPV was associated with a 91% reduction (RR: 0.09; 95% CI: 0.03-0.24; P=0.0001) in the risk of death over the next six months. In contrast, at MPV levels above 9.8, each unit increase in MPV was linked to a 27% increase (RR: 1.27; 95% CI: 1.01-1.61; P=0.0434) in the probability of dying within the same period. Stratification by obesity status revealed no significant association between MPV and death in the obese population, while the same U-shaped association was observed among non-obese participants.
Conclusion:
The present study provides evidence of a U-shaped association between MPV and short-term survival in Chinese patients with heart failure. These findings suggest that MPV may serve as a potential prognostic marker for HF. However, further studies are needed to validate these results and to explore the underlying mechanisms of this association. The observed U-shaped association did not apply to obese patients, suggesting that the effect of MPV on mortality risk in HF patients may be influenced by body weight.
Long-term mindfulness meditators exhibit increased spontaneous occurrence of brain states involving sensory and attention networks
Authors: Panitz Daniel Yochai , Mendelsohn Avi , Cabral Joana , Berkovitch-Ohana Aviva 
Published: June 2023

Abstract
Interest has been growing in the use of mindfulness meditation (MM) as a therapeutic practice, as accumulating evidence highlights its potential to improve various mental functions and effectively address a range of mental conditions. Among the various hypotheses, a shift in the sense-of-self has been proposed as a possible core mechanism of MM, towards enhanced embodied cognition (related with self-specific processing), and away from narrative reflection (related with self-related processing). While fMRI studies focusing on neural activation and functional connectivity generally support this notion, the impact of MM practice on dynamic functional connectivity remains unclear. To fill this gap, in this study, the dynamics of intrinsic functional networks were compared between experienced MM practitioners and age-matched meditation-naïve control participants, to investigate the impact of long-term MM practice on the dynamic expression of resting state networks over time. Our analysis revealed that, when compared to meditation-naïve participants, experienced meditators at rest tend to spend more time in two brain states that involve cortical regions associated with sensory perception, with a heavy emphasis on visual processing. The opposite was found to occur in a brain state involving areas associated with higher cognitive functions and executive control. These findings suggest that MM might lead to a shift from an emphasis on executive control towards enhanced sensory and embodied processing. These results support the notion that long-term MM favors network states associated with self-specific processes and decrease the occurrence of states associated with self-related executive control. Overall, this study reinforces the utility of dynamical systems theory to extend current knowledge regarding the effects of MM on brain function.