bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of novel and low-cost readout electronics for large FOV gamma camera detector
Authors: Radnia Aram , Alikhani Amirhossein , Teimourian Behnoosh , Nejad Mahyar Youser , Farahani Mohammad Hossein , Pashaei Fakhereh , Rahmim Arman , Ay Mohammad Reza 
Published: March 2023

Abstract
Objective: Gamma cameras based on scintillation crystals play a crucial role in nuclear medicine. We designed a readout method for a large field-of-view (FOV) gamma detector, reducing N × M analog signals of photomultiplier tubes (PMTs) to N + M analog sums of each row and column, thus improving complexity and cost considerations while preserving image quality.
Methods: In this study, we developed a gamma detector consisting of 48 square PMTs using novel readout electronics, reducing 6 × 8 to 6 + 8 analog signals. All 14 analog signals were converted to digital signals using AD9257 high-speed analog to digital converters (ADC) driven by the SPARTAN-6 family of field-programmable gate arrays (FPGA) in order to calculate the signal integrals. The positioning algorithm was based on the digital correlated signal enhancement (CSE) algorithm, which was implemented in the acquisition software. The performance characteristics of the developed gamma camera were measured using the NEMA NU1 standard.
Results: The measured energy resolution in the developed detector was 8.7%, intrinsic spatial resolution was 3.9 mm, uniformity was within 0.6%, and linearity was within 0.1%.
Conclusions: The performance evaluation demonstrated that the developed detector has proper specifications for imaging purposes.
Some Fourier transforms involving confluent hypergeometric functions
Authors: Berisha Nimete , Berisha Faton , Fejzullahu Bujar 
Published: March 2023

Abstract
In this paper, we derive some Fourier transforms of confluent hypergeometric functions. We give generalizations of several well-known results involving Fourier transforms of gamma functions. In particular, the generalizations include some Ramanujan's remarkable formulas.
2010 Mathematics Subject Classification. 33C15, 42A38, 44A20.
Cost-effectiveness of MOdified DIagnostic strateGy to safely ruLe-out pulmonary embolism in the emergency depArtment: A Non-Inferiority cluster crossover randomized trial (MODIGLIA- NI)
Authors: OSSIMA Arnaud NZE , SIAHA Bibi Fabiola NGALEU , MIMOUNI Maroua , MEZAOUR Nadia , DARLINGTON meryl , BERARD Laurence , Cachanado Marine , Simon Tabassome , Freund Yonathan , DURAND-ZALESKI Isabelle 
Published: March 2023

Abstract
Background: The aim of this trial-based economic evaluation was to assess the incremental costs and cost-effectiveness of the modified diagnostic strategy combining the YEARS rule and age-adjusted D-dimer threshold compared with the control (which used the age-adjusted D-dimer threshold only) for the diagnosis of pulmonary embolism (PE) in the Emergency Department (ED).
Methods: Economic evaluation from a healthcare system perspective alongside a non-inferiority, crossover, and cluster-randomized trial conducted in 16 EDs in France and two in Spain with three months of follow-up. The primary endpoint was the additional cost of a patient without failure of the diagnostic strategy, defined as venous thromboembolism (VTE) diagnosis at 3months after exclusion of PE during the initial ED visit. Mean differences in 3-month failure and costs were estimated using mixed linear regression models, adjusted for strategy type, period, and the interaction between strategy and period as fixed effects and the hospital as a random effect. The incremental cost-effectiveness ratio (ICER) was obtained by dividing the incremental costs by the incremental frequency of VTE.
Results: Of the 1414 included patients, 1217 (86%) were analyzed in the per-protocol analysis (648 in the intervention group and 623 in the control group). At three month, there were no statistically significant differences in total costs (€-47; 95% CI: €-103 to €4), and the failure rate was non inferior in the intervention group (-0.64%, one-sided 97.5% CI: -∞ to 0.21%, non-inferiority margin 1.5%) between groups. The point estimate of the incremental cost-effectiveness ratio (ICER) calculated that each patient without diagnostic failure was associated with cost savings of €7,343 in the intervention strategy compared with the controls. There was a 90% probability that the intervention was dominant. Similar results were found in the as randomized population.
Conclusions: This trial suggests that there is an economic advantage to using the YEARS rule combined with the PERC rule and the age-adjusted D-dimer threshold in PERC-positive patients, as this strategy is non-inferior and less costly than the standard diagnostic strategy.
Trial registration number ClinicalTrials.gov Identifier: NCT04032769; July 25, 2019
ATPase H+ Transporting V0 Subunit C regulates Twinfilin Actin Binding Protein 1 and promotes metastatic ability of esophageal cancer
Authors: Qiao Bingzhang , Yu Weijie , Ainiwaer Julaiti , Niyaz Madinyat , Zhang Liwei , Sheyhidin Ilyar 
Published: March 2023

Abstract
We aimed at investigating the implication of ATP6V0C in esophageal cancer (ECa) and exploring how ATP6V0C participates in this process. ATP6V0C expression in 46 pairs of ECa tissues was determined by RT-PCR analysis, and the relationship between ATP6V0C and clinicopathological indicators as wells as prognosis of ECa patients was analyzed. Results demonstrated that ATP6V0C was significantly increased in ECa.Participants with high- ATP6V0C exhibited markedly higher incidence of metastasis and shorter survival rates. Inhibition of ATP6V0C attenuated cell invasive and metastasis abilities. Meanwhile, Luciferase assay confirmed the binding between ATP6V0C and TWF1. TWF1 expression showed an increase in ECa cell lines and tissues, which was positively correlated with ATP6V0C level. In addition, we found that overexpression of TWF1 counteracted the effects of knockdown of ATP6V0C on the proliferation and migration of ECa, and thus affect the malignant progression of ECa. ATP6V0C and TWF1 are both highly expressed and positively correlated in tumor tissues of ECa patients. In addition, ATP6V0C accelerated the malignant progression of ECa cells through interacting with TWF1.
Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: A retrospective cohort study
Authors: Zhan Cuixia , Peng Yuan , Ye Hongjian , Diao Xiangwen , Yi Chunyan , Guo Qunying , Chen Wei , Yang Xiao 
Published: March 2023

Abstract
Background: Recent studies have shown that triglyceride glucose-body mass index (TyG-BMI) is associated with the risk of ischemic stroke and coronary artery disease.
However, little attention has been paid to the association between TyG-BMI and cardiovascular disease (CVD) mortality in patients undergoing peritoneal dialysis (PD). Therefore, this study aimed to explore the relationship between TyG-BMI and CVD mortality in Southern Chinese patients undergoing PD.
Methods: Incident patients receiving PD during January 1, 2006, to December 31, 2018, with baseline serum triglycerides, glucose, and body mass index (BMI) information, were recruited for this single-center retrospective cohort study. TyG-BMI was calculated based on fasting plasma glucose, triglyceride, and BMI values. The association between TyG-BMI, CVD and all-cause mortality was evaluated using a multivariate-adjusted Cox proportional hazard regression model.
Results: Of 2,335 patients, the mean age was 46.1±14.8 years; 1,382 (59.2%) were male, and 564 (24.2%) had diabetes. The median TyG-BMI was 183.7 (165.5–209.2). Multivariate linear regression showed that advanced age, male sex, history of CVD, higher levels of albumin and low-density lipoprotein cholesterol, and higher urine output were correlated with a higher TyG-BMI (P<0.05). During a median follow-up period of 46.6 (22.4–78.0) months, 615 patients died, of which 297 (48.2%) died as a result of CVD. After adjusting for demographics and comorbidities, TyG-BMI was significantly associated with an increased risk of CVD mortality (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.05–2.17) and all-cause mortality (HR 1.36, 95%CI 1.05–1.75). After full adjustment, 28% risk of CVD mortality (HR 1.28, 95%CI 1.13‒1.45) and 19% risk of all-cause mortality elevated (HR 1.19, 95%CI 1.09‒1.31) when TyG-BMI increased by 1-Stand Deviation (SD) (34.2).
Conclusions: A higher baseline TyG-BMI was independently associated with an increased risk of CVD and all-cause mortality in patients receiving PD.
Aggregation pheromones released by nymphs of the stick tea thrips (Dendrothrips minowai): identification and analysis of their potential utility for controlling thrips in tea plantations
Authors: Xiu Chunli , Zhang Fengge , Pan Hongsheng , Luo Zongxiu , Bian Lei , Li Zhaoqun , Fu Nanxia , Zhou Li , Magsi Fida Hussain , Cai Xiaoming Cai , Chen Zongmao 
Published: March 2023

Abstract
BACKGROUND
The stick tea thrips, Dendrothrips minowai Priesner, is one of the most important sucking pests that seriously infest tea plants (Camellia sinensis) in China. Obvious D. minowai nymph aggregation behaviors are typically detected in tea plantations. The objectives in our study were to identify D. minowai aggregation pheromones and evaluate their potential utility for controlling thrips infestations in tea plantations.
RESULTS
Dendrothrips minowai nymphs, females, and males were significantly attracted to nymph volatiles rather than the volatiles secreted by females and males in H-tube olfactometer assays under laboratory conditions. Our gas chromatography-mass spectrometry analysis of volatiles collected from D. minowai revealed that nymphs can produce dodecyl acetate and tetradecyl acetate. Additionally, the D. minowai females and males responded positively to dodecyl acetate, tetradecyl acetate, and the mixture (dodecyl acetate : tetradecyl acetate = 1 : 1.5) according to in behavioral experiments under laboratory conditions. Moreover, both aggregation pheromones and the mixture increased the number of D. minowai adults on sticky traps by 0.9- to 2.5-times (compared with the traps containing the solvent control) in tea plantations. Most importantly, at 10 days after adding sticky traps with D. minowai aggregation pheromones to tea plantations, the number of adult thrips per 100 leaves decreased by 57–75%, which was significantly higher than those of 39% decrease induced by the solvent control.
CONCLUSION
Dodecyl acetate and tetradecyl acetate were identified as D. minowai nymph-produced aggregation pheromones that can significantly attract conspecifics under laboratory conditions. More importantly, combining the aggregation pheromones with sticky traps can significantly decrease the thrips population in tea plantations. The findings of this study on thrips pheromones may be useful for developing new methods for managing thrips that do not require potentially harmful insecticides.
Clinicopathological features of incidentally detected metastatic thyroid papillary carcinoma in cervical lymph nodes of non-thyroid cancer patients: a retrospective analysis of 31cases
Authors: Hu Chunfang , Zhang Haifeng , Chu Lixia , Qiu Tian , Lu Haizhen 
Published: March 2023

Abstract
Background
The incidental finding of thyroid inclusions in lymph nodes of neck dissections of non-thyroid cancer patients is an unusual event. It is still controversial for pathologists for whether this represents benign inclusions or metastatic papillary thyroid carcinoma (PTC). This study is to analyze clinicopathological features of such cases in attempt to explore their clinical implications.
Methods
Pathological data were searched for incidentally detected PTC of cervical lymph nodes in non-thyroid cancer cases. Clinicopathological characteristics were reevaluated and recorded. BRAF V600E protein expression and sequencing analysis was then performed in cases with sufficient tissues.
Results
31 patients had an incidental finding of PTC in lymph nodes of patients with non-thyroid cancer. BRAF immunohistochemical staining were performed in 17 metastatic lymph nodes with sufficient tumor tissues, and 6 were positive. BRAF V600E point mutation was detected in 5 of 6 BRAF V600E positive cases. Subsequent imaging examination of the thyroid showed undetected nodules or calcifications/benign nodules in twenty patients, and suspected malignant nodules in 5 patients. 12 patients underwent total thyroidectomy or ipsilateral lobectomy, and 6 showed PTC in postoperative pathological examinations. The remaining 19 patients without surgery were kept under active surveillance, and no one had recurrence of PTC.
Conclusion
Incidentally discovered PTC in lymph nodes have usually interpreted as metastasis from a clinical occult thyroid primary cancer, but primary PTC was not always detected. This suggests it would be double occult lesions. With regards to concurrence with highly malignant tumor, most patients could keep regular surveillance.
Determination of Magnetic Susceptibility and Metal Enrichment Sediments Traps of High Altitude Himalayan Lake, The Chandratal Spiti, Himachal Pradesh, India
Authors: Rout Sonam Priyadharshini , S Vasudevan , S Baranidharan , J Vigneshwar , G Sathiyamoorthy 
Published: March 2023

Abstract

High Altitude Lake have a complex mechanism because they are influenced by glacial climatic conditions, weathering of bedrocks and river transportation and deposition, which causes enrichment of metal concentration and magnetic components in the zone. The present study investigated the magnetic properties and their relation between geochemistry of 11 surface sediment samples and 01 core sediment sample in the High Altitude Himalayan Lake, The Chandratal Spiti. The Geoaccumulation Index of the all metals concentration shows extremely high values than standard ranges > 5 (extremely polluted). The Magnetic susceptibility of χLF substantial higher at surface sampling point 8 and core sediment at depth of 42 to 44 cm and 80 to 82 cm. Simultaneously the χFD% (< 2% - No super paramagnetic grains/multi domain grain size) shows drastically decrease at χLF maximum points. With the XRD mineralogy analysis shows mostly Zircon, Illite and Quartz minerals proves the lake sedimentology. The χLF / χFD ratio were found to be an obvious parameter for identifying areas of sediment traps and metal enrichment in the surface sediment and temporal sediments of High Altitude Lake. The high χLF / χFD at surface sampling point 8 and at depth as 42 to 44 cm and 84 to 86 cm probably arose because the point is in large magnetic sediment traps zone. The Pb210 and Cs137 has linearly correlated with the χLF / χFD sediment trapped peak of the core sediment at the depth 42 to 44 cm infers the age as 1991 and 1993 years.
Robotic versus laparoscopic proctectomy: A comparative study of short-term economic and clinical outcomes
Authors: Larach José Tomás , Flynn Julie , Tew Michelle , Fernando Diharah , Apte Sameer , Mohan Helen , Kong Joseph , McCormick Jacob J. , Warrier Satish K. , Heriot Alexander G. 
Published: March 2023

Abstract
Aim: This study aims to compare the financial and clinical outcomes of robotic and laparoscopic proctectomy within a public healthcare system.
Methods:Consecutive patients undergoing laparoscopic and robotic proctectomy between January 2017 and June 2020 in a public quaternary centre were included. Demographic characteristics, baseline clinical, tumour and operative variables, perioperative, histopathological outcomes and costs were compared between the laparoscopic and robotic groups. Simple linear regression and generalised linear model analyses with gamma distribution and log-link function were used to determine the impact of the surgical approach on overall costs.
Results: During the study period, 113 patients underwent minimally invasive proctectomy. Of these, 81 (71.7%) underwent a robotic proctectomy. A taTME component was more often utilised in the laparoscopic group (34.4% versus 13.6%;P=0.003). Demographic and baseline clinical variables were otherwise similar between groups. A robotic approach was associated with a lower conversion rate (2.5% versus 21.8%;P=0.002) at the expense of longer operating times (284±83.4 versus 243±89.8 minutes;P=0.025). Regarding financial outcomes, robotic surgery was associated with increased theatre costs (A$23019±8235 versus A$15525±6382; P<0.001) and overall costs (A$34350±14770 versus A$26083±12647; P=0.003). Hospitalisation costs were similar between both approaches. An ASA ≥ 3, non-metastatic disease, low rectal cancer, neoadjuvant therapy, non-restorative resection, extended resection, and a robotic approach were identified as drivers of overall costs in the univariate analysis. However, after performing a multivariate analysis, a robotic approach was not identified as an independent driver of overall costs during the inpatient episode (P=0.1).
Conclusion: Robotic proctectomy was associated with increased theatre costs but not with increased overall inpatient costs within a public healthcare setting. Conversion was less common for robotic proctectomy at the expense of increased operating time. Larger studies will be needed to confirm these findings and examine the cost-effectiveness of robotic proctectomy to further justify its penetration in the public healthcare system.
Management of marandu grass pasture increases soil carbon and nitrogen stocks in forest grazing systems in the Brazilian Cerrado
Authors: Anésio Arnon Henrique Campos , Santos Márcia Vitória , Frazão Leidivan Almeida , Teixeira Rafael Bastos , Tuffi-Santos Leonardo David , Pegoraro Rodinei Facco , Barboza Josiane Aparecida de Souza , Dumont Mariana Almeida , Paschoaloto Josimari Regina 
Published: March 2023

Abstract
This paper aimed to evaluate the influence of management practices of marandu grass, at eucalyptus shading levels in a forest grazing system, on organic carbon (OC) and nitrogen (N) stocks, and on soil chemical characteristics in the Brazilian Cerrado. The experimental design adopted was entirely random with five repetitions. In the plots were allocated the environments with different light availability, and a treatment with marandu grass in full sun. The management of marandu grass pasture was distributed in the subplots with pre-pasture at 30, 40, 50, and 60 cm high. Evaluations were repeated in two crop cycles in year 1 and year 2. Soil chemical characteristics, OC and N stocks were analyzed. The management of marandu grass at 50 cm height in the forest grazing system provided higher levels of OC, N, organic matter in the soil and an increase in fertility, compared to monoculture pasture, with repercussions in two years. The integration of eucalyptus and marandu grass pasture contributes with greater stocks of OC and N in the soil strips closest to the tree row, due to greater nutrient cycling. Marandu grass in forest grazing systems with shading varying from 40 to 60% present greater efficiency and maintenance of soil chemical attributes, demonstrating greater sustainability compared to monoculture pastures.
Return to work improves quality of life and reduces psychosocial distress after radical cystectomy – data from a contemporary series of 230 German Patients
Authors: Bahlburg Henning , Reike Moritz , Tully Karl , Bach Peter , Butea-Bocu Marius Cristian , Roghmann Florian , Noldus Joachim , Müller Guido 
Published: March 2023

Abstract
Purpose:
This study aims to evaluate health-related quality of life (HRQoL), psychosocial distress, and return to work (RTW) two years after radical cystectomy (RC) and inpatient rehabilitation (IR).
Material and Methods:
The study relied on prospectively collected data for 842 patients, who underwent three weeks of IR after RC and creation of an ileal conduit (IC) or ileal neobladder (INB). Validated questionnaires surveyed patients on HRQoL and psychosocial distress (EORTC QLQ-C30, QSC-R10). Furthermore, employment status was evaluated. Regression was performed to identify predictors for HRQol, psychosocial distress, and RTW.
Results:
Two-hundred and thirty patients were employed pre-surgery (77.8% INB, 22.2% IC). Patients with an IC suffered significantly more often from locally advanced disease (≥pT3: 43.1% vs 22.9%; p=0.004). Two years after surgery, 16.1% of patients had died (median days of survival 302 (IQR 204-482). Global HRQoL improved steadily, while high psychosocial distress was present in 46.5% of patients two years after surgery. Employment was reported by 68.2% of patients, of which 90.3% worked full-time. Retirement was reported by 18.5%. Multivariate logistic regression analysis identified age ≤59 years as the only positive predictor for RTW two years after surgery (OR 7.730; 95% CI 3.369-17.736; p<0.001). Gender, surgical technique, tumor stage, and socioeconomic status did not influence RTW in this model. In multivariate linear regression analysis, RTW was identified as an independent predictor of better global HRQoL (p=0.018) and lower psychosocial distress (p<0.001), whereas younger patient age was identified as an independent predictor for higher psychosocial distress (p=0.002).
Conclusion:
Global HRQoL and RTW are high among patients two years after RC. However, role, emotional, cognitive, and social functioning were significantly impaired, while high psychosocial distress persists in a material number of patients.
Implications for Cancer Survivors:
Our study highlights, how a successful RTW decreases psychosocial distress and increases QoL in patients after RC for urothelial cancer. Nonetheless, additional efforts by employers and healthcare providers are needed in aftercare after creation of an INB or IC.
Hydrogeological structure of the subterranean river system of Yutang and a karst depression reservoir in Yunnan Province, China
Authors: Zhang Wenping , Pan Xiaodong , Liang Jianhong , Zeng Jie , Song Chen 
Published: March 2023

Abstract
Karst groundwater resources are rich, and they have important water supply significance. However, the complex hydrogeological structure of karst areas and the many subterranean river conduits make the development and utilization of karst groundwater resources very challenging. Therefore, the Yibasan Karst reservoir (YKR) was selected as the focus of this study. The hydrogeological structure of the subterranean river system of Yutang (SRSY) was identified and the hydraulic connections between the subterranean river conduits were determined using tracer experiment and groundwater dynamic monitoring. Furthermore, the development location and depth of the karst seepage zone of the YKR were determined using geophysical exploration. The results showed that there were three subterranean river conduits in the SRSY, and there was no hydraulic connection. The northern and southern pressure and torsion faults on the sides constituted the impervious boundary of the SRSY, which provided good catchment conditions for the formation of the YKR. Additionally, the northern and main conduits of the SRSY provide a sufficient groundwater source for the YKR. Moreover, the development width of the karst seepage zone of the YKR ranged between 40 and 60 m, and the elevation ranged between 1275 and 1355 m. The research results not only provide an effective basis for the treatment of the karst seepage problem of the YKR but also provide an important reference for the development and utilization of groundwater resources in similar karst areas.