bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life-threatening complication of retropharyngeal abscess in an infant: a case report
Authors: Rehman Ayaz Ur , Khan Salman , Abbas Awais , Pasha Hamdan Ahmad , Abbas Qalab , Siddiqui Naveed Ur Rehman 
Published: August 2023

Abstract
Background
Deep neck space infections are uncommon in infants. Retropharyngeal abscess (RPA) is a deep space neck infection that can present with subtle signs and symptoms. Delay in diagnosis can lead to life-threatening complications. Here we describe life-threatening complication of retropharyngeal abscess.

Case presentation
We report a life-threatening complication of retropharyngeal abscess in 10-month old Asian infant weighing 8.2 kg. The patient presented with fever, right-sided neck swelling, hoarseness of voice, and respiratory distress. The clinical and radiological findings were suggestive of airway obstruction complicated by retropharyngeal abscess. The patient was urgently taken to the operating room and underwent (grade 3) intubation. After stabilization, the patient underwent endoscopic trans-oral incision and drainage, during which 5 cc pus was aspirated. Antibiotics were prescribed for 2 weeks following the procedure based on the sensitivity result of the pus culture.

Conclusion
In retropharyngeal abscess, a delay in diagnosis can result in life-threatening complications. This report highlights the importance of prompt recognition of a threatened airway and the management of retropharyngeal abscess by emergency physicians. If an emergency physician suspects RPA with airway obstructions, the airway should be immediately secured in a secure environment by otolaryngologist and an anesthesiologist.
Repetitive and compulsive behavior after Early-Life-Pain associated with reduced long-chain sphingolipid species
Authors: Vogel Alexandra , Ueberbach Timo , Wilken-Schmitz Annett , Hahnefeld Lisa , Franck Luisa , Weyer Marc-Philipp , Jungenitz Tassilo , Schmid Tobias , Buchmann Giulia , Freudenberg Florian , Brandes Ralf P. , Gurke Robert , Schwarzacher Stephan W. , Geisslinger Gerd , Mittmann Thomas , Tegeder Irmgard 
Published: August 2023

Abstract
Background
Pain in early life may impact on development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of “early-life-pain” (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin (Avil) promoter, which drives expression of transgenes predominantly in isolectin B4 positive non-peptidergic nociceptors in postnatal mice. Avil-ChR2 (Cre +) and ChR2-flfl control mice were exposed to blue light in a chamber once daily from P1-P5 together with their Cre-negative mother.

Results
ELP caused cortical hyperexcitability at P8-9 as assessed via multi-electrode array recordings that coincided with reduced expression of synaptic genes (RNAseq) including Grin2b, neurexins, piccolo and voltage gated calcium and sodium channels. Young adult (8–16 wks) Avil-ChR2 mice presented with nociceptive hypersensitivity upon heat or mechanical stimulation, which did not resolve up until one year of age. The persistent hypersensitivy to nociceptive stimuli was reflected by increased calcium fluxes in primary sensory neurons of aged mice (1 year) upon capsaicin stimulation. Avil-ChR2 mice behaved like controls in maze tests of anxiety, social interaction, and spatial memory but IntelliCage behavioral studies revealed repetitive nosepokes and corner visits and compulsive lickings. Compulsiveness at the behavioral level was associated with a reduction of sphingomyelin species in brain and plasma lipidomic studies. Behavioral studies were done with female mice.

Conclusion
The results suggest that ELP may predispose to chronic “pain” and compulsive psychopathology in part mediated by alterations of sphingolipid metabolism, which have been previously described in the context of addiction and psychiatric diseases.

Graphical Abstract
Amoxicillin-induced aseptic meningitis: clinical features, diagnosis and management
Authors: Fan Zhiqiang , He Yang , Sun Wei , Li Zuojun , Ye Chao , Wang Chunjiang 
Published: August 2023

Abstract
Objectives
The clinical features of aseptic meningitis associated with amoxicillin are unknown. The main objective of this study was to investigate the clinical characteristics of amoxicillin-induced aseptic meningitis (AIAM) and provide a reference for clinical diagnosis and treatment.

Methods
AIAM-related studies were collected by searching the relevant databases from inception to October 31, 2022.

Results
AIAM usually occurred 3 h to 7 days after amoxicillin administration in 13 males and 9 females. Twenty-one patients (95.5%) had recurrent AIAM with a total of 62 episodes. Fever (19 cases, 86.4%) and headache (18 cases, 81.8%) were the most common symptoms. Typical cerebrospinal fluid (CSF) findings were leukocytosis (100%) with lymphocytic predominance (14 cases, 63.6%), elevated protein (20 cases, 90.1%), normal glucose (21 cases, 95.5%) and negative culture (21 cases, 100%). Brain magnetic resonance imaging showed mild meningeal enhancement in one patient. The symptoms resolved mainly within 1–4 days after drug discontinuation in all patients.

Conclusion
Clinical attention should be given to the adverse effects of AIAM. The medication history of patients with suspected meningitis should be investigated to avoid unnecessary examination and antibiotic treatment.
Bispecific antibodies and dual-targeting CAR-T cells for multiple myeloma: latest updates from the 2023 ASCO annual meeting
Authors: Hou Jiangxue , Li Yufu , Lin Quande 
Published: August 2023

AbstractBispecific antibodies (BsAbs) and dual-targeted chimeric antigen receptor T (CAR T) cells have been employed in relapsed/refractory multiple myeloma (RRMM) patients over the past few years, as an increasing number of patients were ineffectively treated by ≥ 3 prior lines of therapy. BCMA/CD3 and GPRC5D/CD3 are the most popular combinations. Clinical findings indicated that patients exhibit a greater susceptibility to stronger and more enduring responses. Here, we summarize the latest data from the 2023 ASCO annual meeting on BsAbs targeting BCMA/CD3, GPRC5D/CD3 and BCMA/CD19 CAR T cells.
Stratified microbial communities in Australia’s only anchialine cave are taxonomically novel and drive chemotrophic energy production via coupled nitrogen-sulphur cycling
Authors: Ghaly Timothy M. , Focardi Amaranta , Elbourne Liam D. H. , Sutcliffe Brodie , Humphreys William , Paulsen Ian T. , Tetu Sasha G. 
Published: August 2023

AbstractBackgroundAnchialine environments, in which oceanic water mixes with freshwater in coastal aquifers, are characterised by stratified water columns with complex physicochemical profiles. These environments, also known as subterranean estuaries, support an abundance of endemic macro and microorganisms. There is now growing interest in characterising the metabolisms of anchialine microbial communities, which is essential for understanding how complex ecosystems are supported in extreme environments, and assessing their vulnerability to environmental change. However, the diversity of metabolic strategies that are utilised in anchialine ecosystems remains poorly understood.ResultsHere, we employ shotgun metagenomics to elucidate the key microorganisms and their dominant metabolisms along a physicochemical profile in Bundera Sinkhole, the only known continental subterranean estuary in the Southern Hemisphere. Genome-resolved metagenomics suggests that the communities are largely represented by novel taxonomic lineages, with 75% of metagenome-assembled genomes assigned to entirely new or uncharacterised families. These diverse and novel taxa displayed depth-dependent metabolisms, reflecting distinct phases along dissolved oxygen and salinity gradients. In particular, the communities appear to drive nutrient feedback loops involving nitrification, nitrate ammonification, and sulphate cycling. Genomic analysis of the most highly abundant members in this system suggests that an important source of chemotrophic energy is generated via the metabolic coupling of nitrogen and sulphur cycling.ConclusionThese findings substantially contribute to our understanding of the novel and specialised microbial communities in anchialine ecosystems, and highlight key chemosynthetic pathways that appear to be important in these energy-limited environments. Such knowledge is essential for the conservation of anchialine ecosystems, and sheds light on adaptive processes in extreme environments.
A systematic review on big data applications and scope for industrial processing and healthcare sectors
Authors: Rahul Kumar , Banyal Rohitash Kumar , Arora Neeraj 
Published: August 2023

AbstractNowadays, big data is an emerging area of computer science. Data are generated through different sources such as social media, e-commerce, blogs, banking, healthcare, transactions, apps, websites, opinion platforms, etc. It is processed for effective utilization in different industries, including healthcare. These enormous generated data are essential for data analysis and processing for industrial needs. This paper reviews the work of various authors who have contributed to data collection, analyzing, processing, and viewing to explore the importance and possibilities of big data in industrial processing applications and healthcare sectors. It identifies different opportunities and challenges (data cleaning, missing values, and outlier analysis) along with applications and features of big data. This systematic review further proposed dirty data detection and cleaning and outlier detection models that can be used for many applications. The data cleaning and outlier detection models use the optimizations concept to solve the optimal centroid selection problem and suspected data.
Potential influencing factor on health‐related quality of life in Japanese with knee osteoarthritis: the Locomotive syndrome and Health outcome in Aizu cohort Study (LOHAS)
Authors: Otoshi Kenichi , Kikuchi Shinichi , Otani Koji , Sonobe Tatsuru , Sekiguchi Miho , Konno Shinichi 
Published: August 2023

AbstractPurposeSeveral studies have investigated the factors that influence health‐related quality of life in patients with knee osteoarthritis (KOA). This study aimed to identify and investigate the degree of involvement of potential factors influencing health‐related quality of life (HRQOL) in an aged population with or without KOA.MethodsThis multi‐centered study included 651 participants who underwent health checkups in rural areas of Japan in 2010. The association between three component summary score of short‐form 12 (physical component summary; PCS, mental component summary; MCS, and role‐social component summary; RCS) and covariates were investigated using multiple linear regression model and calculated the scaled estimated regression coefficient.ResultsDecreasing mobility, severity of knee pain, high pain‐related self‐efficacy (PSE), older age, high functional self‐efficacy (FSE), and female gender had significant effect on PCS (p < 0.05). However, radiographic KOA had no influence on PCS. Presence of depression and body mass index had a significant influence on the MCS (p < 0.05). Decreasing mobility, presence of depression, PSE and older age had significant influence on the RCS (p < 0.05).ConclusionOur study results showed that physical, mental, and role/social QOL were affected by different influencing factors. Physical QOL was strongly influenced by subjective pain, physical performance, and self‐efficacy, whereas radiographic KOA had no such effect. Depressive mood is associated with both mental and role/social QOL. The role/social QOL was predominantly affected by physical function and pain‐related self‐efficacy. Taking measure to improving functional ability and mental status might be the key factor to improve HRQOL in patient with KOA.Level of evidenceLevel 3: Epidemiologic cross‐sectional study (prognostic study)
Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis
Authors: Gomez Alwyn , Sainbhi Amanjyot Singh , Stein Kevin Y. , Vakitbilir Nuray , Froese Logan , Zeiler Frederick A. 
Published: August 2023

Abstract
Background
Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity are limited by their invasive nature and poor spatial resolution. Fortunately, interest has been building around near infrared spectroscopy (NIRS) based measures of cerebrovascular reactivity that utilize regional cerebral oxygen saturation (rSO2) as a surrogate for pulsatile cerebral blood volume (CBV). In this study, the relationship between ICP- and rSO2-based indices of cerebrovascular reactivity, in a cohort of critically ill TBI patients, is explored using classical machine learning clustering techniques and multivariate time-series analysis.

Methods
High-resolution physiologic data were collected in a cohort of adult moderate to severe TBI patients at a single quaternary care site. From this data both ICP- and rSO2-based indices of cerebrovascular reactivity were derived. Utilizing agglomerative hierarchical clustering and principal component analysis, the relationship between these indices in higher dimensional physiologic space was examined. Additionally, using vector autoregressive modeling, the response of change in ICP and rSO2 (ΔICP and ΔrSO2, respectively) to an impulse in change in arterial blood pressure (ΔABP) was also examined for similarities.

Results
A total of 83 patients with 428,775 min of unique and complete physiologic data were obtained. Through agglomerative hierarchical clustering and principal component analysis, there was higher order clustering between rSO2- and ICP-based indices, separate from other physiologic parameters. Additionally, modeled responses of ΔICP and ΔrSO2 to impulses in ΔABP were similar, indicating that ΔrSO2 may be a valid surrogate for pulsatile CBV.

Conclusions
rSO2- and ICP-based indices of cerebrovascular reactivity relate to one another in higher dimensional physiologic space. ΔICP and ΔrSO2 behave similar in modeled responses to impulses in ΔABP. This work strengthens the body of evidence supporting the similarities between ICP-based and rSO2-based indices of cerebrovascular reactivity and opens the door to cerebrovascular reactivity monitoring in settings where invasive ICP monitoring is not feasible.
A mobile robot driven by uniaxial wave locomotion mechanism
Authors: Yoshida Kento , Nagaoka Kenji 
Published: August 2023

AbstractThis paper presents a novel mobile robot system that uses a uniaxial wave locomotion mechanism. The proposed mechanism can mechanically produce uniaxial surface waves by a single actuator to rotate a helix component that has discrete helical wings. This involves multiple pins with springs and a link mechanism. We designed and developed a mobile robot consisting of a main body and two helical wave locomotion units arranged in parallel. This paper also presents a locomotion model based on the proposed mechanics. The developed robot prototype demonstrated mobility on various surfaces and its skid-steering performance was evaluated. The experimental results validated the feasibility of the proposed wave-locomotion mechanism.
Safety and efficacy of interventional treatment of acute limb ischemia in Germany 2021
Authors: Bastian Moritz B. , Nadjiri Jonathan , Wessendorf Joel , Scheschenja Michael , König Alexander M. , Jedelska Jarmila , Mahnken Andreas H. 
Published: August 2023

Abstract
Purpose
Interventional procedures have become a mainstay in the therapy of acute limb ischemia caused by embolism or arterial thrombosis. Treatment options include pharmacological thrombolysis (PT) and mechanical thrombectomy (MT). The aim of this study was to evaluate success and major complication rates of interventional radiological treatments of arterial embolism and thrombosis in Germany in 2021 and to compare their results with accepted international quality standards.

Materials and methods
Data for PT and MT for 2021 was obtained from the quality management system of the German interventional radiological society (DeGIR). 2431 PT and 1582 MT procedures were documented for 2021, with 459 combinations of PT and MT. Data was analysed for technical and clinical success rates, as well as major complication rates such as intracranial bleeding, major bleeding, distal embolization, aneurysm formation, organ-failure and cardiac-decompensation.

Results
PT alone had technical and clinical success rate of 90.21% and 81.08%, respectively. MT alone had technical and clinical success rates of 97.41% and 95.39%, respectively. MT&PT had technical and clinical success rates of 91.07% and 84.75%, respectively. Major complications were: distal embolization (PT:2.02%; MT:1.74%; PT&MT:2.61%), major bleeding (PT:0.94%; MT:1.14%; PT&MT:0.87%), aneurysm formation (PT:0.33%;MT: 1.14%;PT&MT: 0%), intracranial bleeding (PT:0.16%;MT:0%;PT&MT:0.22%), cardiac-decompensation (PT:0.21%;MT: 0.06%;PT&MT:0%) and organ-failure (PT:0%;MT:0.06%;PT&MT:0.22%).
Technical and clinical success rates were higher, while complication rates were lower than the corresponding threshold recommended by the Society of Interventional Radiology for percutaneous management of acute lower-extremity ischemia.

Conclusion
Treatment of arterial embolism and thrombosis performed by interventional radiologists in Germany is effective and safe with outcomes exceeding internationally accepted standards.
C-reactive protein as a biomarker for unipolar versus bipolar depression: a cross-sectional study
Authors: Dessoki Hani Hamed , Khattab Rasha Abd El Razek , Moris Wagdy , Abdelhakim Ahmed Abdelaziz Ezzat , Lotfy Alshimaa Mohsen Mohamed , Salah Hisham 
Published: August 2023

Abstract
Background
Differentiating unipolar depression from bipolar depression is clinically important. The identification of biomarkers that characterize the pathophysiology of each disorder may provide biological targets for treatment. The objective of the study was to demonstrate a relationship between CRP level and the severity of depressive symptoms and see if C-reactive protein (CRP) levels can be used as a biomarker to distinguish between unipolar and bipolar depression. A convenience sample of 90 individuals was consecutively recruited from the psychiatry outpatient clinic at Beni-Suef University Hospital, Egypt. They were divided into three equal groups: patients with major depressive disorder (MDD) (group 1), bipolar depression (group 2), and a healthy volunteer group (group 3). Patient groups were assessed using semi-structured interviews, and CRP levels were measured.

Results
Patients with bipolar depression and MDD showed a significantly higher score on the Beck Depression Inventory scale than the control group (32.97 ± 2.4 vs. 31.93 ± 2.3 vs. 8.00 ± 2.3 in all groups respectively) (P-value < 0.001). Patients with bipolar depression and MDD showed a significantly higher serum CRP level than the control group (134.96 ± 16.45 vs. 133.86 ± 17.59 vs.56.04 ± 26.71 vs. in all groups respectively) (P-value < 0.001). In all studied groups, elevated plasma CRP levels have a significant linear correlation with the severity of depression as measured by the Beck Depression Inventory (BDI) (r = 0.887, P-value < 0.001).

Conclusions
Serum CRP levels are significantly higher in MDD and BD patients when compared to controls. Individuals with higher CRP levels had more severe depression, and this finding was significantly higher in women than in men.
Healthcare provider’s performance monitoring for undercovered population during the Covid-19 epidemic, 2021, Tehran: a cross-sectional study
Authors: Oroomi Fatemeh Sharifi , Shahrousvand Shokouh , Hosseini Mahboobeh Mohammad , Tavakolikia Narjes , Taammoli Saeed , Hesari Elahe , Vosoogh-Moghadam Abbas 
Published: August 2023

Abstract

Background
Considering the necessity and importance of providing health care to children during the Covid-19 epidemic, this study aims to investigate primary health workers performance for infants under 6 months during the Covid-19 epidemic and parent’s satisfaction level with these services.

Methods
This was a cross-sectional study conducted among the defined population of Tehran University of Medical Sciences. The descriptive analysis focused on frequencies and percentages. A chi-square test was used to compare the categorical data between the studied groups.

Results
Three-hundred seventy-two participants from two District Health Networks of Islamshahr 90 (24%) and Shahr-e-rey 107 (29%) and South Tehran Health Center 175 (47%) were included in the study. About 45% of 2 months old, 54% of 4 months old, and 42% of 6 months old received full basic healthcare package. Coverage of services such as vaccination and height, weight, and head circumference in all three age groups and health networks was 100%. Training in handwashing, touch the face, and hygiene while breastfeeding (64.4%, p = 0.043) and not to use a pacifier (64%, p = 0.038) in Islamshahr Health Network was significantly less than other health networks. The level of parental satisfaction with the provided services was 90.1%. There is a significant association between the dissatisfaction of the participants and not receiving the services completely (p = 0.000).

Conclusion
During the Covid-19 pandemic, the quality and quantity of primary health care to children have been declined. The focus of health workers was on essential physical health services for infants, and education was almost neglected during this period.
Skeletal Muscle Function Is Altered in Male Mice on Low-Dose Androgen Receptor Antagonist or Estrogen Receptor Agonist
Authors: Momb Brent A , Szabo Gillian K , Mogus Joshua P , Chipkin Stuart R , Vandenberg Laura N , Miller Mark S 
Published: August 2023

Abstract
In males, skeletal muscle function may be altered by shifts in either circulating testosterone or estrogen. We examined the effect of acute (2-week) exposures to 17α-ethinyl estradiol (EE2), an estrogen receptor (ER) agonist, or flutamide, an androgen receptor (AR) antagonist, on the contractile function of individual skeletal muscle fibers from slow-contracting soleus and fast-contracting extensor digitorum longus muscles from adult male mice. Single fiber specific tension (force divided by cross-sectional area) was decreased with flutamide treatment in all myosin heavy chain (MHC) fiber types examined (I, IIA, and IIB); similar effects were observed with EE2 treatment but only in the fastest-contracting MHC IIB fibers. The decreases in maximally Ca2+-activated specific tension were primarily a result of fewer strongly bound myosin-actin cross-bridges, with flutamide treatment also showing lower myofilament lattice stiffness. Myosin-actin cross-bridge kinetics were slower in MHC IIA fibers in flutamide-treated mice, but faster in EE2-treated mice, indicating that contractile velocity may be affected differently in this fiber type, which is commonly expressed in human skeletal muscle. Importantly, these effects were observed in the absence of outcomes previously used to evaluate ER agonists or AR antagonists in rodents including weight of reproductive organs or mammary gland morphology. Our findings indicate that substantial shifts in skeletal muscle function occur in male mice following acute exposures to low doses of a pharmacological ER agonist and an AR antagonist. These results suggest that countermeasures to maintain physical function may be needed early in situations that induce similar ER agonist and AR antagonist conditions.