bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mechanism of Leonuri Herba in improving polycystic ovary syndrome was analyzed based on network pharmacology and molecular docking
Authors: Wu Mali , Liu Hua , Zhang Jie , Dai Fangfang , Gong Yiping , Cheng Yanxiang 
Published: February 2023

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting women. Chinese herbs have been considered as an alternative treatment for PCOS, and Yi-mu-cao (Leonuri Herba) is one of the most commonly used herbs to treat PCOS, which can relieve symptoms of PCOS patients. But the mechanism of its treatment remains unclear.Method: The main active ingredients and potential targets of Leonuri Herba were obtained by TCMSP and Swiss Target Forecast, and the related targets of PCOS were obtained by searching DrugBank, GeneCard and DisGeNet databases. The Protein-Protein Interaction (PPI) network was constructed using STRING database. GO and KEGG were used to detect the enrichment pathways of key targets. Cytoscape software was used to construct the component-target-pathway network, analyze the PPI network core, and verify the reliability of target binding by molecular docking technology.Result: 8 components and 116 targets of Leonuri Herba on PCOS were screened. Common targets mainly involve the Lipid and atherosclerosis, Endocrine resistance, AGE-RAGE signaling in diabetic complications and other signaling pathways. It is suggested that it can form multi-target and multi-pathway regulatory network through quercetin, kaempferol and other active substances to regulate endocrine disorders and reduce inflammatory response, so as to systematically improve PCOS. Molecular docking experiments showed that the active constituents of Leonurus had good binding activity with potential targets of PCOS.Conclusion: In summary, this study elucidates the potential effect of Leonuri Herba on PCOS, which is helpful to provide reference for clinical practice. This is also conducive to the secondary development of motherwort and its monomer components, and precision medicine for PCOS.
Gastrointestinal perforation associated with novel antineoplastic agents: A real-world study based on the FDA Adverse Event Reporting System
Authors: Yu Zicheng , Zhu Haibin , Chen Hongjun , Zhu Lifei , Liao Xiaolan 
Published: February 2023

Purpose: Gastrointestinal perforation (GIP) is a fatal adverse event (AE). The AE of GIP induced by novel antineoplastic agents has attracted attention recently. We aimed to explore the AE signals of GIP related to novel antineoplastic agents comprehensively based on the FDA Adverse Event Reporting System (FAERS).Methods: The FAERS database containing 71 quarters of records was used for analysis. Reporting odds ratio (ROR), information component (IC), and empirical Bayesian geometric mean (EBGM) were utilized to evaluate the signals of GIP associated with novel antineoplastic drugs. Standardization of drug names was by employing MedEx-UIMA software and Python. Data analysis and visualization were performed using MySQL Workbench and R software.Results: After cleaning and handling the data, 5226 GIP cases were identified that were associated with new antineoplastic medications, where these agents were the main suspected contributors. A total of 37 novel antineoplastic drugs were detected with signals of GIP for ROR and IC. Only 22 drugs showed statistically significant signals for EBGM. We found the GIP signals of 22 novel antineoplastic drugs overlapped for the 3 indicators, including anti-vascular endothelial growth factor/vascular endothelial growth factor receptor, anti-endothelial growth factor receptor, immune checkpoint inhibitors, and so on.Conclusion: The potential risk of GIP associated with several novel antineoplastic agents was identified through data mining, which provided valuable information on the safety risks associated with GIP among these drugs. The potential threat of GIP should be recognized and managed properly when using these novel antineoplastic agents.
Seroprevalence of Brucella Infection in Wild Boars (Sus scrofa) of Bavaria, Germany, 2019 to 2021 and Associated Genome Analysis of Five B. suis Biovar 2 Isolates
Authors: Macías Luaces Laura , Boll Kerstin , Klose Corinna , Domogalla-Urbansky Janina , Müller Matthias , Eisenberger David , Riehm Julia M. 
Published: February 2023

Brucella species are highly pathogenic zoonotic agents and are found in vertebrates all over the world. To date, Germany is officially declared free from brucellosis and continuous surveillance is currently limited to farm ruminants. However, porcine brucellosis, mostly caused by B. suis biovar 2, is still found in wild boars and hares. In the present study, a three-year monitoring program was conducted focusing on the wild boar population in the state of Bavaria. Serologic screening of 11,956 animals and a direct pathogen detection approach, including a subset of 681 tissue samples, was carried out. The serologic incidence was 17.9%, which is in approximate accordance with previously published results from various European countries. Applying comparative whole genome analysis, five isolated B. suis biovar 2 strains from Bavaria could be assigned to three known European genetic lineages. One isolate was closely related to another strain recovered in Germany in 2006. Concluding, porcine brucellosis is endemic in Bavaria and the wild boar population represents a reservoir for genetically distinct B. suis biovar 2 strains. However, the transmission risk of swine brucellosis to humans and farm animals is still regarded as minor due to low zoonotic potential, awareness, and biosafety measures.
Um moderno amazônico: obras residenciais do arquiteto Severiano Porto em Manaus/AM
Authors: Guerreiro Ana do Nascimento , Abrahim Ana Lúcia da Silva , De Farias Taise Costa 
Published: February 2023

A presente pesquisa é resultado de um projeto de extensão vinculado ao curso de graduação em Arquitetura e Urbanismo da Universidade Nilton Lins e tem como objetivo principal a analise projetual de quatro obras residenciais do arquiteto Severiano Porto na cidade de Manaus/AM. A análise projetual caracteriza-se por uma leitura reflexiva e crítica da arquitetura, sendo essencial para o conhecimento dos processos e estratégias dos projetos residenciais do arquiteto. Severiano Porto foi um dos arquitetos brasileiros pioneiros a atuar na região amazônica, onde buscou uma identidade regional para a arquitetura moderna, tendo consciência de que os fatores regionais deveriam ser estudados para aplicação adequada no projeto. Nesta pesquisa serão anlisadas as residencias: “Casa do Cafundó”, “Casa Porto”, “Casa Robert Schuster”, e a “Casa Alexandre Alê dos Santos”; através de um roteiro metodológico que utiliza o redesenho e a modelagem 3D para a compreensão dos projetos no âmbito projetual, construtivo, funcional e plástico. A pesquisa se baseia tanto na relevancia projetual e conceitual das obras do arquiteto, quanto pelo fato dessas produções ainda serem pouco conhecidas e documentadas. Assim, a presente pesquisa visa também contribuir para a melhor compreensão das obras do arquiteto Severiano Porto e os estudos sobre a arquitetura amazonense.
Microalgas y su uso como bioindicadoras en la laguna lobos y cuatro arroyos (Buenos Aires, Argentina)
Authors: Barraza Ana , Torremorell Ana , Giorgi Adonis 
Published: February 2023

Los sistemas lóticos pampeanos constituyen una unidad única de paisaje, siendo la baja velocidad de corriente, la ausencia de plantas leñosas y el escaso sustrato rocoso principales características que regulan el desarrollo de los productores primarios, permitiendo el crecimiento del fitoplancton. Esta comunidad, cobra relevancia y llega a ser vital para sostener e integrar las tramas tróficas acuáticas. Para estudiarla estudio se establecieron 10 sitios de muestreo en verano entre la laguna de Lobos y sus afluentes, los arroyos Salgado, Las Garzas y Salvador María y el arroyo el Toro efluente de la laguna (Provincia de Buenos Aires-Argentina). En estos sitios se tomaron muestras de agua para los análisis fisicoquímicos, peso seco y clorofila y muestras de plancton para análisis cualitativo y cuantitativo. Se determinaron 110 morfoespecies de algas fitoplanctónicas en total, distribuidas en 8 clases y 21 órdenes. Los grupos taxonómicos más abundantes fueron Cyanophyceae y Bacillariophyceae siendo Cylindrospermopsis raciborskii, Phormidium sp., Cyclotella meneghiniana y Nitzschia palea, las especies dominantes. La presencia de estos organismos, el análisis de los valores de la biomasa algal y la concentración de clorofila y nutrientes, indican un cambio en el estado trófico incrementándose de eutrófico a hipeurtrófico, por lo que se recomiendan monitoreos periódicos.
STUDI PERBANDINGAN TINGKAT KEBUGARAN JASMANI SD INPRES BERTINGKAT MAMAJANG IV DENGAN SD INPRES PERUMNAS ANTANG III
Authors: Jamaluddin Jamaluddin , Mutmainah Ulfa , Bismar Ahmad Rum 
Published: February 2023

Tingkat kebugaran jasmani penting dalam aktivitas sehari-hari murid. Letak geografis mempunyai pengaruh terhadap keadaan tingkat kebugaran jasmani anak. Penelitian ini bertujuan untuk mengetahui perbedaan tingkat kebugaran jasmani murid SD Inpres Mamajang IV dengan SD Inpres Perumnas Antang III Makassar. Penelitian ini merupakan penelitian komparatif. Subyek dalam penelitian ini adalah seluruh murid SD Inpres Mamajang IV dengan SD Inpres Perumnas Antang III Makassar yang berumur 10-12 tahun. Pengumpulan data menggunakan tes dengan isntrumen Tes Kebugaran Jasmani Indonesia (TKJI) usia 10-12 tahun dari Depdiknas. Populasi dalam penilitian ini berjumlah 740 murid, jumlah sampel yang dipilih 60 murid dengan menggunakan teknik cluster sampling. Teknik analisis data menggunakan analisis uji t melalui uji prasyarat uji normalitas dan uji homogenitas. Hasil penelitian menunjukkan bahwa terdapat perbedaan Tingkat Kebugaran Jasmani murid SD Inpres Bertingkat Mamajang IV dengan SD Inpres Perumnas Antang III Makassar. Tingkat kebugaran jasmani murid SD Inpres Perumnas Antang III Makassar lebih baik daripada SD Inpres Bertingkat Mamajang IV. Tingkat kebugaran jasmani murid SD Inpres Perumnas Antang III Makassar sebagian besar siswa mempunyai tingkat kebugaran jasmani dalam kategori sedang, dan kurang dengan nilai 13,87 sedangkan pada siswa SD Inpres Bertingkat Mamajang IV sebagian besar murid dalam kategori kurang dan sedang dengan nilai 12,10. Dengan demikian tingkat kebugaran jasmani murid SD Inpres Perumnas Antang III Makassar dapat dikatakan lebih baik daripada murid SD Inpres Mamajang IV.
PENERAPAN LATIHAN BEBAN PERGELANGAN TANGAN UNTUK MENINGKATKAN KEMAMPUAN FOREHAND BULU TANGKIS PADA SISWA KELAS VIII SMP NEGERI 24 PALEMBANG
Authors: Hardianti Putri , Lian Bukman , Kristina Putri Cicilia , Gemael Qorry Armen 
Published: February 2023

Tujuan penelitian ini adalah guna untuk mengetahui apakah ada pengaruh antara latihan menggunakan beban atau latihan tidak menggunakan beban. Penerapan Latihan Beban Pergelangan Tangan Untuk Meningkatkan Kemampuan Forehand Pada Siswa Kelas Viii Smp Negeri 24 Palembang. Penelitian ini menggunakan metode eksperimen dengan pendekatan kuantitatif. Populasi dalam penilitian ini Populasi pada penelitian ini melibatkan kelas VIII yang berjumlah 10 kelas. Sampel penelitian ini adalah 16 orang peserta didik putra dan putri dengan cara teknik purposive sampling teknik pengambilan sampel yang memberikan peluang yang baik. Instrumen dalam penelitian ini menggunakan tes forehand. mean = 9,375 yang berarti selisih antara hasil belajar sebelum dan sesudah diberikan pembelajaran menggunakan latihan beban pergelangan tangan. Diperoleh std. error mean yang menunjukan angka kesalahan 2,135 yang berarti terdapat kesalahan perbedaan rata-rata. Kemudian hal terpenting dari tabel statistik t = 4,392 dengan df = 15 dan angka sig. atau p-value sebesar 0,001 < 0,05 yang berarti ditolak. Sehingga dapat disimpulkan bahwa ada pengaruh yang signifikan antara kemampuan forehand sebelum dan sesudah diberikan latihan beban pergelangan tangan.
Desigualdad y Exclusión Educativa en el Contexto de Pandemia. Experiencias de Jóvenes de una Telesecundaria Rural
Authors: Benítez Jaramillo José Federico 
Published: February 2023

El presente artículo teje a la juventud como categoría que se articula con las clases virtuales y televisadas en donde se hacen presente las literacidades en contextos de desigualdad y exclusión educativa los cuales se vinculan para dar cuenta de una realidad que se habita hoy y que particularizo desde sus propios contextos. Así, se abordan las categorías de desigualdad y exclusión educativa, en la idea de construir reflexiones y mirar los desafíos que existen en los espacios rurales en México y de forma particular las problemáticas que hacen visibles los y las jóvenes en el contexto de pandemia. Su propósito es develar algunas experiencias desde las voces de Briseida y Mario estudiantes de Telesecundaria en donde retratan las desigualdades que históricamente han vivido y que se han acrecentado a partir del confinamiento causado por la pandemia. Los sujetos que se aluden en este artículo son parte de una investigación más amplia que se desarrolló en el Sur del Estado de México en los límites del Estado de Guerrero y Michoacán. Se construyó a partir del enfoque teórico en la que usamos la ecología de saberes (Santos, 2009) y otras perspectivas decoloniales (Mignolo, 2007; Castro-Gómez, 2005) que son transversales con las ideas de la investigación y metodologías indisciplinadas (Wallerstein, 1996; Haber, 2001; Gorbach & Rufer, 2016), además de recurrir a los estudios socioculturales de juventud (Valenzuela, 2013; Nateras, 2016; Reguillo, 2010; Pérez Islas, 2012), asimismo asumimos que la investigación es de corte cualitativo, interpretativo comprensivo, utilizando como posibilidad metodológica al método biográfico-narrativo (Bolívar, Domingo y Fernández, 2001), las técnicas que se usaron fueron la entrevista biográfica para construir las narrativas a partir de diferentes encuentros dialógicos con 16 jóvenes de una Telesecundaria rural. Donde sus voces nos posibilitaron la construcción de nuevas miradas para re-pensar la escuela en un contexto de pandemia.
Thin, flexible, and biocompatible medical ultrasound array transducer using a sol–gel composite spray technique
Authors: Tanabe Masayuki , Sato Kosuke , Uda Toru , Kobayashi Makiko 
Published: February 2023

Abstract
A thin, flexible, and biocompatible medical ultrasonic transducer was developed using a sol–gel composite spray technique to fabricate a single sheet of piezoelectric material. The careful selection of materials prioritized flexibility, with silicone rubber being chosen for its biocompatibility as the material to be in direct contact with the living body. A porous lead zirconate titanate film with a dielectric constant of 134 was generated, and comb-shaped electrodes were printed on the piezoelectric film to form a 64-channel linear array, which successfully suppressed crosstalk values between adjacent elements and at a distance of two elements to −41.5 and −45.8 dB, respectively. Experiments using string targets achieved a spatial resolution of 2 mm in the lateral direction and 0.68 mm in the axial direction. In an imaging experiment of the carotid artery, the transducer was successful in visualizing the vessel wall before and after the carotid artery vessel.
Determinants of Interest Using QRIS as a Payment Technology For E-Wallet by Z Generation in Indonesia
Authors: Mareta Yossi , Meiryani Meiryani 
Published: February 2023

In the midst of the rapid growth of financial technology companies that act as payment system service providers (PJSP) in Indonesia continue to innovate,the Quick Response Code Indonesian Standard(QRIS)is present as a solution to implement innovations in payment systems offered by these fintech companies.
This study aims to identify the factors that influence the interest of Gen Z in using the QRIS payment system in the e-wallet. This study used systematic literature review. The result of the study shows that perceived ease of use, perceived usefulness, trust, social influence, dan promotion have a positive, while risk has a negative influence on the interest of Gen Z in Indonesia in using the QRIS payment system in E-wallet.
Optimization of dyeing processes by compounds isolated from bark of Myrica esculenta and their spectroscopy identification
Authors: Janwgan J.S. , Dobhal Maneesha , Sati S. C. 
Published: February 2023

Myrica esculenta (Myricaceae) commonly known as Kaphal is a small aromatic evergreen tree, abundantly grows in the sub-tropi cal Hi malaya from K ash mi r to Bh u tan . Common l y assoc i ate d wi th Oak an d Rhododenderon forests. The bark of the tree is utilized for its astringent, stimulant and resolvent properties. The decoction of the bark along with cinnamone is given in chronic cough and piles. The bark of the plant is used as a dye in ancient Indian traditions and also as a natural mordant. The berries of the plant is one of th e ri ch est source of wax, u se d as a raw mate ri al for c an dl e an d soap maki ng i ndustrie s. A n umbe r of flavonoids, tannins, Xanthones, terpines and many other anthocyanins have been isolated from the different part of th e plant. The pre se nt pape r de als with isolati on and ch arac te rization of se condary metabol ites namely 2-methyl pyrane 3-O--D-glucoside and Flavone 3,’4,’ dihydroxy 6-methyl 7-O--L-rhamnopyranoside from the plant and optimization of dyeing procedure with isolated compounds on different fibres like silk, wool, cotton etc with and without natural and synthetic mordants. Efforts will be made to check the washing and ligh t fastness properties of dyed samples.
A study of biotic and abiotic factors of Song River at Dehradun, Uttarakhand
Authors: Khanna D.R. , Singh Vikas , Bhutiani R. , Chandra Kumar Satish , Matta Gagan , Kumar Dheeraj 
Published: February 2023

The present study deals with the analysis of physico-chemical parameters of the Song river at Dehradun, Uttarakhand during the pre-autumn, autumn and post-autumn months of 2007. In the present study of the Song river its physico- chemical characteristics viz temperature, velocity, total solids, total suspended solids, total dissolved solids, turbidity, pH, dissolved oxygen, free CO , BOD, COD, alkalinity, chlorides, sulphate and identification of fishes were done. The data revealed that 36 species of fishes are present in the Song river of Dehradun, Uttarakhand.
KRITIK SOSIAL DAN NILAI MORAL INDIVIDU TOKOH UTAMA DALAM NOVEL LAUT BERCERITA KARYA LEILA S. CHUDORI
Authors: Navira Surya Andani  , Resdianto Permata Raharjo  , Titik Indarti  
Published: February 2023

Kritik sosial dan nilai-nilai moral selalu tertuang dalam suatu karya sastra karena merupakan cerminan dari realitas sosial di masyarakat. Adapun tujuan dari penelitian ini adalah mengetahui bentuk-bentuk kritik sosial dan nilai moral individu yang dapat diteladani dalam novel Laut Bercerita karya Leila S. Chudori. Penelitian ini menggunakan pendekatan kualitatif dengan teknik pengumpulan data simak dan catat. Dari penelitian ini dapat ditemukan perwujudan kritik sosial yang berupa 1) Pihak berwajib dan penguasa tidak mampu melindungi rakyat kecil, 2) masyarakat yang malas berbenah diri, 3) penindasan untuk mendapatkan informasi, 4) penyelewengan hegemoni dan ideologi pemerintahan, 5) pergerakan radikalisme mahasiswa, 6) tindakan sewenang-wenang kepada petani dan empat nilai moral individu yang diantaranya 1) pantang menyerah, 2) suka membantu, 3) kesetiaan, dan 4) rela berkorban. Kesimpulan yang didapatkan yaitu masih banyak ketimpangan sosial yang terjadi di dalam masyarakat oleh karena itu, pengarang mewadahi kritik sosial dan nilai-nilai moral melalui karya sastra agar pembaca senantiasa peka terhadap konflik-konflik yang terjadi di lingkungan sosial.
The Emphatic Marker in Turkish: Two Readings
Authors: Kayabasi Demet 
Published: February 2023

This paper aims to show that the anaphor kendi in Turkish has two distinct readings depending on when it’s functioning as an emphatic marker, which hasn’t been noted in the previous literature. I propose that it has two distinct readings based on their surface sentential positions and diagnostics from Ahn (2010). Moreover, I show that the event modifying a variety of the emphatic marker in Turkish differs from the same type of emphatic marker in English by showing that (i) it allows theme/patient referents, and the DP modifying variety (ii) may be able to survive without obligatory stress. In addition, I document further observations and nuances regarding the morphological marking of the two varieties of the emphatic marker in Turkish as preliminary discussion points.
Astrophysical Properties of 600 Bona Fide Single Stars in the Hyades Open Cluster
Authors: Brandner Wolfgang , Calissendorff Per , Kopytova Taisiya 
Published: February 2023

Abstract
The determination of the astrophysical properties of stars remains challenging and frequently relies on the application of stellar models. Stellar sequences in nearby open clusters provide some of the best means to test and calibrate stellar evolutionary models and isochrones and to use these models to assign astrophysical properties consistently to a large sample of stars. We aim at updating the single-star sequence of the members of the Hyades cluster, identifying the best-fitting isochrones, and determining the astrophysical properties of the stars. The Gaia Catalog of Nearby Stars provides a comprehensive sample of high-probability members of the Hyades cluster. We apply a multistep method to flag photometric outliers and to identify bona fide single stars and likely binary and multiple systems. The single stars define a tight sequence, which in the mass range 0.12–2.2 M
⊙ is well fitted by PARSEC isochrones for a supersolar metallicity of [M/H] = +0.18 ± 0.03 and an age of 775 ± 25 Myr. The isochrones enable us to assign mass, effective temperature, luminosity, and surface gravity to each of the 600 bona fide single main-sequence stars. The observed sequence validates the PARSEC isochrones. The derived stellar properties can serve as benchmarks for atmospheric and evolutionary models and for all-sky catalogs of stellar astrophysical properties. The stellar properties are also relevant for studies of exoplanet properties among Hyades exoplanet hosts.
Cosmicflows-4
Authors: Tully R. Brent , Kourkchi Ehsan , Courtois Hélène M. , Anand Gagandeep S. , Blakeslee John P. , Brout Dillon , Jaeger Thomas de , Dupuy Alexandra , Guinet Daniel , Howlett Cullan , Jensen Joseph B. , Pomarède Daniel , Rizzi Luca , Rubin David , Said Khaled , Scolnic Daniel , Stahl Benjamin E. 
Published: February 2023

Abstract
With Cosmicflows-4, distances are compiled for 55,877 galaxies gathered into 38,065 groups. Eight methodologies are employed, with the largest numbers coming from the correlations between the photometric and kinematic properties of spiral galaxies (TF) and elliptical galaxies (FP). Supernovae that arise from degenerate progenitors (type Ia SNe) are an important overlapping component. Smaller contributions come from distance estimates from the surface brightness fluctuations of elliptical galaxies and the luminosities and expansion rates of core-collapse supernovae (SNe II). Cepheid period–luminosity relation and tip of the red giant branch observations founded on local stellar parallax measurements along with the geometric maser distance to NGC 4258 provide the absolute scaling of distances. The assembly of galaxies into groups is an important feature of the study in facilitating overlaps between methodologies. Merging between multiple contributions within a methodology and between methodologies is carried out with Bayesian Markov chain Monte Carlo procedures. The final assembly of distances is compatible with a value of the Hubble constant of H
0 = 74.6 km s−1 Mpc−1 with the small statistical error of ±0.8 km s−1 Mpc−1 but a large potential systematic error of ∼3 km s−1 Mpc−1. Peculiar velocities can be inferred from the measured distances. The interpretation of the field of peculiar velocities is complex because of large errors on individual components and invites analyses beyond the scope of this study.