bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey by the European Society of Breast Imaging on radiologists’ preferences regarding quality assurance measures of image interpretation in screening and diagnostic mammography
Authors: Michalopoulou Eleni , Clauser Paola , Gilbert Fiona J. , Pijnappel Ruud M. , Mann Ritse M. , Baltzer Pascal A.T. , Chen Yan , Fallenberg Eva Maria 
Published: July 2023

Abstract
Objectives
Quality assurance (QA) of image interpretation plays a key role in screening and diagnostic mammography, maintaining minimum standards and supporting continuous improvement in interpreting images. However, the QA structure across Europe shows considerable variation. The European Society of Breast Imaging (EUSOBI) conducted a survey among the members to collect information on radiologists’ preferences regarding QA measures in mammography.

Materials and methods
An anonymous online survey consisting of 25 questions was distributed to all EUSOBI members and national breast radiology bodies in Europe. The questions were designed to collect demographic characteristics, information on responders’ mammography workload and data about QA measures currently used in their country. Data was analysed using descriptive statistical analysis, the χ2 test, linear regression, and Durbin-Watson statistic test.

Results
In total, 251 breast radiologists from 34 countries completed the survey. Most respondents were providing both screening and symptomatic services (137/251, 54.6%), working in an academic hospital (85/251, 33.9%) and reading 1000–4999 cases per year (109/251, 43.4%). More than half of them (133/251, 53%) had established QA measures in their workplace. Although less than one-third (71/251, 28.3%) had to participate in regular performance testing, the vast majority (190/251, 75.7%) agreed that a mandatory test would be helpful to improve their skills.

Conclusion
QA measures were in place for more than half of the respondents working in screening and diagnostic mammography to evaluate their breast imaging performance. Although there were substantial differences between countries, the importance of having QA in the workplace and implemented was widely acknowledged by radiologists.

Clinical relevance statement
Although several quality assurance (QA) measures of image interpretation are recommended by European bodies or national organisations, the QA in mammography is quite heterogenous between countries and reporting settings, and not always actively implemented across Europe.

Key Points

The first survey that presents radiologists’ preferences regarding QA measures of image interpretation in mammography.

Quality assurance measures in the workplace are better-established for breast screening compared to diagnostic mammography.

Radiologists consider that performance tests would help to improve their mammography interpretation skills.
Artificial intelligence to improve cytology performance in urothelial carcinoma diagnosis: results from validation phase of the French, multicenter, prospective VISIOCYT1 trial
Authors: Lebret Thierry , Paoletti Xavier , Pignot Geraldine , Roumiguié Mathieu , Colombel Marc , Savareux Laurent , Verhoest Grégory , Guy Laurent , Rigaud Jérome , De Vergie Stéphane , Poinas Grégoire , Droupy Stéphane , Kleinclauss François , Courtade-Saïdi Monique , Piaton Eric , Radulescu Camelia , Rioux-Leclercq Nathalie , Kandel-Aznar Christine , Renaudin Karine , Cochand-Priollet Béatrix , Allory Yves , Nivet Sébastien , Rouprêt Morgan 
Published: July 2023

Abstract
Purpose
Cytology and cystoscopy, the current gold standard for diagnosing urothelial carcinomas, have limits: cytology has high interobserver variability with moderate or not optimal sensitivity (particularly for low-grade tumors); while cystoscopy is expensive, invasive, and operator dependent. The VISIOCYT1 study assessed the benefit of VisioCyt® for diagnosing urothelial carcinoma.

Methods
VISIOCYT1 was a French prospective clinical trial conducted in 14 centers. The trial enrolled adults undergoing endoscopy for suspected bladder cancer or to explore the lower urinary tract. Participants were allocated either Group 1: with bladder cancer, i.e., with positive cystoscopy or with negative cystoscopy but positive cytology, or Group 2: without bladder cancer. Before cystoscopy and histopathology, slides were prepared for cytology and the VisioCyt® test from urine samples. The diagnostic performance of VisioCyt® was assessed using sensitivity (primary objective, 70% lower-bound threshold) and specificity (75% lower-bound threshold). Sensitivity was also assessed by tumor grade and T-staging. VisioCyt® and cytology performance were evaluated relative to the histopathological assessments.

Results
Between October 2017 and December 2019, 391 participants (170 in Group 1 and 149 in Group 2) were enrolled. VisioCyt®’s sensitivity was 80.9% (95% CI 73.9–86.4%) and specificity was 61.8% (95% CI 53.4–69.5%). In high-grade tumors, the sensitivity was 93.7% (95% CI 86.0–97.3%) and in low-grade tumors 66.7% (95% CI 55.2–76.5%). Sensitivity by T-staging, compared to the overall sensitivity, was higher in high-grade tumors and lower in low-grade tumors.

Conclusion
VisioCyt® is a promising diagnostic tool for urothelial cancers with improved sensitivities for high-grade tumors and notably for low-grade tumors.
Noradrenergic tone is not required for neuronal activity-induced rebound sleep in zebrafish
Authors: Benoit Eleanor , Lyons Declan G. , Rihel Jason 
Published: July 2023

AbstractSleep pressure builds during wakefulness, but the mechanisms underlying this homeostatic process are poorly understood. One zebrafish model suggests that sleep pressure increases as a function of global neuronal activity, such as during sleep deprivation or acute exposure to drugs that induce widespread brain activation. Given that the arousal-promoting noradrenergic system is important for maintaining heightened neuronal activity during wakefulness, we hypothesised that genetic and pharmacological reduction of noradrenergic tone during drug-induced neuronal activation would dampen subsequent rebound sleep in zebrafish larvae. During stimulant drug treatment, dampening noradrenergic tone with the α2-adrenoceptor agonist clonidine unexpectedly enhanced subsequent rebound sleep, whereas enhancing noradrenergic signalling with a cocktail of α1- and β-adrenoceptor agonists did not enhance rebound sleep. Similarly, CRISPR/Cas9-mediated elimination of the dopamine β-hydroxylase (dbh) gene, which encodes an enzyme required for noradrenalin synthesis, enhanced baseline sleep in larvae but did not prevent additional rebound sleep following acute induction of neuronal activity. Across all drug conditions, c-fos expression immediately after drug exposure correlated strongly with the amount of induced rebound sleep, but was inversely related to the strength of noradrenergic modulatory tone. These results are consistent with a model in which increases in neuronal activity, as reflected by brain-wide levels of c-fos induction, drive a sleep pressure signal that promotes rebound sleep independently of noradrenergic tone.
Meludia platform as a tool to evaluate music perception in pediatric and adult cochlear implant users
Authors: Calvino Miryam , Zuazua Alejandro , Sanchez-Cuadrado Isabel , Gavilán Javier , Mancheño Marta , Arroyo Helena , Lassaletta Luis 
Published: July 2023

Abstract
Purpose
Music perception is one of the greatest challenges for cochlear implant (CI) users. The aims of this study were: (i) to evaluate the music perception of CI users using the online Meludia music training program as music testing platform, (ii) to compare performance among three age groups, and (iii) to compare CI users with their normal hearing (NH) peers.

Methods
138 individuals participated, divided between children (6–10 y), adolescents (11–16 y), and adults (≥ 17 y). Five music perception tasks were evaluated: Rhythm, Spatialization, Stable/unstable, Melody, and Density. We also administered the music related quality of life (MuRQoL) questionnaire for adults, and a music questionnaire for pediatric population (6–16 y) (MuQPP).

Results
A significantly higher percentage of the adolescent CI users completed the five tasks compared to the other age groups. Both pediatric and adolescent CI users had similar performance to their NH peers in most categories. On the MuRQoL, adult NH listeners reported more music exposure than CI users (3.8 ± 0.6 vs 3.0 ± 0.6, p < 0.01), but both groups reported similar levels of perceived music importance (3.4 ± 0.7 vs 3.2 ± 1.1, p = 0.340). On the MuQPP, pediatric CI users who scored highly on music perception also had higher reported questionnaire scores (54.2 ± 12.9 vs 40.9 ± 12.1, p = 0.009).

Conclusions
Meludia can be used to evaluate music perception and to use for music training in CI users of all ages. Adolescents had the highest performance in most musical tasks. Pediatric CI users were more similar to their NH peers. The importance of music in adult CI users was comparable to their NH peers.
Apatite evidence for a fluid-saturated, crystal-rich magma reservoir forming the Quellaveco porphyry copper deposit (Southern Peru)
Authors: Nathwani Chetan L. , Large Simon J. E. , Brugge Emily R. , Wilkinson Jamie J. , Buret Yannick ,   EIMF
Published: July 2023

AbstractLarge volume, intermediate-felsic magma reservoirs are the source of melt and mineralising fluids which generate porphyry copper deposits. Cooling and crystallisation of hydrous magmas drives the exsolution and expulsion of a magmatic volatile phase—a process which remains challenging to constrain in porphyry Cu systems where the record of magma volatile compositions is rarely preserved. Here, we use the halogen compositions of apatite inclusions shielded as inclusions within zircon to constrain volatile evolution in magma reservoirs which pre-date and are synchronous with porphyry Cu mineralisation at Quellaveco, Southern Peru. Geochemical and textural data confirm that the zircon-included apatites escaped re-equilibration with hydrothermal fluids, unlike apatites found in the groundmass of the same rocks. We, therefore, recommend that future studies attempting to reconcile magmatic volatile budgets using apatite in porphyry Cu systems should focus on apatite inclusions in zircon. By combining the apatite inclusion data with numerical modelling, we find evidence that the magma reservoir sourcing porphyry Cu mineralisation remained fluid-saturated for the entire period recorded by apatite crystallisation. By contrast, the pre-mineralisation batholith shows more variable, potentially fluid-undersaturated behaviour. Our modelling suggests that in order to attain the porphyry melt volatile compositions inferred from apatite, the magma reservoir must have exsolved a large proportion of its volatile budget, consistent with having been held at high crystallinity (40–60% crystals). This crystallisation interval coincides with peak chlorine and copper extraction from intermediate-felsic magmas, and would have permitted efficient fluid migration and accumulation at the roof of the system. We suggest that the storage of large-volume, long-lived, crystal-rich magma reservoirs in magmatic arcs may be a critical step in generating world-class porphyry copper deposits.
The crust-mantle transition beneath the Azores region (central-north Atlantic Ocean)
Authors: Zanon Vittorio , Silva Rita , Goulart Catarina 
Published: July 2023

AbstractThe Azores region straddles the Mid-Atlantic Ridge and comprises volcanic islands and seamounts interspersed with non-magmatic oceanic basins arranged along subparallel slow-spreading systems. The cross-check of CO2-rich fluid inclusions barometry from lavas and tephras erupted during the last 20 ka with the sources of seismicity of the last 22 years traced the deepest magma accumulation zone at a regional scale. These zones are considered to represent the boundary between the dense rocks of magma systems and the lithospheric mantle. This boundary is at a depth range of ~ 17 to 20 km beneath the islands close to the Mid-Atlantic Ridge, which are younger than 500 ka, and up to ~ 29.4 km beneath the eastern island of S. Miguel, younger than 800 ka and the nearby Dom João de Castro Seamount and the Hirondelle Basin. The same method has been applied to the ~ 2 Ma-old volcanic products of Flores, the ~ 1.9 Ma old S. Jorge and the 5 Ma-old lavas of Santa Maria. Results revealed a depth of ~ 30.5 km beneath the Flores and ~ 26 km beneath the ~ 1.9 Ma-old S. Jorge. These two islands are west and east of the Mid-Atlantic Ridge, within 200 km. Finally, the crust-mantle transition has been found below Santa Maria, the easternmost island, ~ 500 km away from the Mid-Atlantic Ridge at a depth of ~ 33 km. Overall, repeated mafic magma injections at the base of each magma system generated vertically stacked layered ultramafic mush bodies, which thickened the crust overtime.
Disability in cerebellar ataxia syndromes is linked to cortical degeneration
Authors: Conrad Julian , Huppert Anna , Ruehl Ria Maxine , Wuehr Max , Schniepp Roman , zu Eulenburg Peter 
Published: July 2023

Abstract
Objective
We aimed to relate clinical measures of disability in chronic cerebellar degeneration to structural whole-brain changes using voxel-based and surface-based morphometry (vbm and sbm). We were particularly interested in remote effects of cerebellar degeneration in the cerebral cortex.

Methods
We recruited 30 patients with cerebellar degeneration of different aetiologies (downbeat nystagmus syndrome, DBN n = 14, spinocerebellar ataxia, SCA n = 9, sporadic adult late-onset ataxia, SAOA n = 7). All patients were thoroughly characterised in the motor, cognitive, vestibular and ocular–motor domains. Vbm and sbm were used to evaluate structural differences between cerebellar degeneration patients and a group of healthy age- and gender-matched volunteers. Linear regression models were used to correlate functional measures of disease progression and postural stability with whole brain volumetry.

Results
Patients with SCA and SAOA showed widespread volume loss in the cerebellar hemispheres and less prominently in the vermis. Patients with DBN showed a distinct pattern of grey matter volume (GMV) loss that was restricted to the vestibular and ocular–motor representations in lobules IX, X and V–VII. Falls were associated with brainstem white matter volume. VBM and SBM linear regression models revealed associations between severity of ataxic symptoms, cognitive performance and preferred gait velocity. This included extra-cerebellar (sub-)cortical hubs of the motor and locomotion network (putamen, caudate, thalamus, primary motor cortex, prefrontal cortex) and multisensory areas involved in spatial navigation and cognition.

Conclusion
Functional disability in multiple domains was associated with structural changes in the cerebral cortex.
Two sources of uncertainty in estimating tephra volumes from isopachs: perspectives and quantification
Authors: Yang Qingyuan , Jenkins Susanna F. 
Published: July 2023

AbstractCalculating the tephra volume is important for estimating eruption intensity and magnitude. Traditionally, tephra volumes are estimated by integrating the area under curves fit to the square root of isopach areas. In this work, we study two sources of uncertainty in estimating tephra volumes based on isopachs. The first is model uncertainty. It occurs because no fitted curves perfectly describe the tephra thinning pattern, and the fitting is done based on log-transformed square root of isopach area. The second source of uncertainty occurs because thickness must be extrapolated beyond the available data, which makes it impossible to validate the extrapolated thickness. We demonstrate the importance of the two sources of uncertainty on a theoretical level. We use six isopach datasets with different characteristics to demonstrate their presence and the effect they could have on volume estimation. Measures to better represent the uncertainty are proposed and tested. For the model uncertainty, we propose (i) a better-informed and stricter way to report and evaluate goodness-of-fit, and (ii) that uncertainty estimations be based on the envelope defined by different well-fitted curves, rather than volumes estimated from individual curves. For the second source of uncertainty, we support reporting separately the volume portions that are interpolated and extrapolated, and we propose to test how sensitive the total volume is to variability in the extrapolated volume. The two sources of uncertainty should not be ignored as they could introduce additional bias and uncertainty in the volume estimate.
Forecasting air pollutants using classification models: a case study in the Bay of Algeciras (Spain)
Authors: Rodríguez-García M. I. , Ribeiro Rodrigues M. C. , González-Enrique J. , Ruiz-Aguilar J. J. , Turias I. J. 
Published: July 2023

AbstractThe main goal of this work is to obtain reliable predictions of pollutant concentrations related to maritime traffic (SO2, PM10, NO2, NOX, and NO) in the Bay of Algeciras, located in Andalusia, the south of Spain. Furthermore, the objective is to predict future air quality levels of the principal maritime traffic-related pollutants in the Bay of Algeciras as a function of the rest of the pollutants, the meteorological variables, and vessel data. In this sense, three scenarios were analysed for comparison, namely Alcornocales Park and the cities of La Línea and Algeciras. A database of hourly records of air pollution immissions, meteorological measurements in the Bay of Algeciras region and a database of maritime traffic in the port of Algeciras during the years 2017 to 2019 were used. A resampling procedure using a five-fold cross-validation procedure to assure the generalisation capabilities of the tested models was designed to compute the pollutant predictions with different classification models and also with artificial neural networks using different numbers of hidden layers and units. This procedure enabled appropriate and reliable multiple comparisons among the tested models and facilitated the selection of a set of top-performing prediction models. The models have been compared using several quality classification indexes such as sensitivity, specificity, accuracy, and precision. The distance (d1) to the perfect classifier (1, 1, 1, 1) was also used as a discriminant feature, which allowed for the selection of the best models. Concerning the number of variables, an analysis was conducted to identify the most relevant ones for each pollutant. This approach aimed to obtain models with fewer inputs, facilitating the design of an optimised monitoring network. These more compact models have proven to be the optimal choice in many cases. The obtained sensitivities in the best models were 0.98 for SO2, 0.97 for PM10, 0.82 for NO2 and NOX, and 0.83 for NO. These results demonstrate the potential of the models to forecast air pollution in a port city or a complex scenario and to be used by citizens and authorities to prevent exposure to pollutants and to make decisions concerning air quality.
Non-stationary large-scale statistics of precipitation extremes in central Europe
Authors: Fauer Felix S. , Rust Henning W. 
Published: July 2023

AbstractExtreme precipitation shows non-stationarity, meaning that its distribution can change with time or other large-scale variables. For a classical frequency-intensity analysis this effect is often neglected. Here, we propose a model including the influence of North Atlantic Oscillation, time, surface temperature and a blocking index. The model features flexibility to use annual maxima as well as seasonal maxima to be fitted in a generalized extreme value setting. To further increase the efficiency of data usage, maxima from different accumulation durations are aggregated so that information for extremes on different time scales can be provided. Our model is trained to individual station data with temporal resolutions ranging from one minute to one day across Germany. Models are chosen with a stepwise BIC model selection and verified with a cross-validated quantile skill index. The verification shows that the new model performs better than a reference model without large-scale information. Also, the new model enables insights into the effect of large-scale variables on extreme precipitation. Results suggest that the probability of extreme precipitation increases with time since 1950 in all seasons. High probabilities of extremes are positively correlated with blocking situations in summer and with temperature in winter. However, they are negatively correlated with blocking situations in winter and temperature in summer.
Surgical treatment of popliteomeniscal fascicles tears is associated with better patient-reported outcome measures. A systematic review and meta-analysis
Authors: Masoni Virginia , Giustra Fortunato , Bosco Francesco , Camarda Lawrence , Rovere Giuseppe , Sciannameo Veronica , Berchialla Paola , Massè Alessandro 
Published: July 2023

Abstract
Purpose
Popliteomeniscal fascicles (PMFs) are a component of the popliteal hiatus complex in the knee, and their injury primarily affects young athletes participating in sports activities involving twisting movements. The identification of PMFs tears presents a challenge, often accompanied by lateral pain and a locking sensation. The objective of this systematic review (SR) and meta-analysis is to enhance the suspicion and recognition of PMFs tears, aiming to facilitate the treatment of this condition, particularly in symptomatic young patients.

Methods
A comprehensive search, focused on studies examining PMFs injuries and their treatment, was conducted in four databases, PubMed, Scopus, Embase, and Web of Science. The ROBINS-I tool was used to evaluate the risks of bias. The PRISMA flow diagram was used to conduct the research and select the included studies. A meta-analysis was conducted for the Lysholm score, the Tegner Activity Scale, and the subjective IKDC score. The present SR and meta-analysis was registered on PROSPERO.

Results
Five clinical studies were included in the final analysis, comprising 96 patients. All the patients underwent a preoperative MRI assessment and a diagnostic arthroscopy to detect the PMFs tears, with a subsequent surgical procedure either open or arthroscopically performed. Surgery was associated with the resolution of symptoms. A statistically significant improvement in the Lysholm score (p: 0.0005) and the subjective IKDC score (p: 0.003) after the surgical procedure with respect to the preoperative evaluation was found.

Conclusion
This SR and meta-analysis showed a significant improvement in the Lysholm score and subjective IKDC score following surgery for PMFs tears. However, controversy persists regarding the optimal surgical approach, with current literature favoring arthroscopic procedures.

Level of evidence
IV.