bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral hygiene behaviours and their associated factors in Chinese adolescents: Evidence from the National Oral Health Survey
Authors: Cui Zhiying , Wang Wenhui , Wang Xing , Feng Xiping , Tai Baojun , Hu Deyu , Lin Huancai , Wang Bo , Wang Chunxiao , Zheng Shuguo , Liu Xuenan , Rong Wensheng , Wang Weijian , Si Yan 
Published: February 2023

AbstractTo investigate oral hygiene behaviours and their correlates among Chinese adolescents. This cross-sectional study recruited 118,601 subjects aged 12-15 years from the National Oral Health Survey using multistage cluster sampling. A total of 32.6% of subjects brushed their teeth twice daily, 7.4% used fluoridated toothpaste, and 3.9% cleaned their teeth twice daily with fluoridated toothpaste. Multivariable logistic regression showed the probability of good oral hygiene practices (twice-a-day tooth brushing with fluoridated toothpaste) was higher among these groups: females (AOR: 1.141; 95%CI: 1.072-1.214), 15-year-olds (AOR: 1.786; 95%CI: 1.634-1.952), from urban areas (AOR: 1.389; 95%CI: 1.288-1.497), without siblings (AOR: 1.351; 95%CI: 1.259-1.450), with an educated father (AOR: 1. 605; 95%CI: 1.442-1.788) and mother (AOR: 1.706; 95%CI: 1.530-1.903), having dental visit experiences (AOR: 1.702; 95%CI: 1.589-1.823), rating one’s oral health as good (AOR: 2.341; 95%CI: 2.083-2.631), having fluoride knowledge (AOR: 4.345; 95%CI: 4.034-4.678) and having a positive attitude towards regular dental care (AOR: 1.589; 95%CI: 1.460-1.729). The oral hygiene behaviours of Chinese adolescents were undesirable. Good oral hygiene practices are significantly associated with sociodemographic factors, fluoride knowledge, and attitudes towards regular dental care. Twice-a-day tooth brushing with fluoridated toothpaste is essential when designing the content of oral health education and when counselling adolescents.
Effects of treatment with corticosteroids on human rhinovirus-induced asthma exacerbations in pediatric inpatients: a prospective observational study
Authors: Kan-o Keiko , Washio Yasuyoshi , Oki Takeshi , Fujimoto Tsuguto , Ninomiya Takahito , Yoshida Makoto , Fujita Masaki , Nakanishi Yoichi , Matsumoto Koichiro 
Published: February 2023

Abstract
Human rhinoviruses (HRVs) infection is a common cause of exacerbations in pediatric patients with asthma. However, the effects of corticosteroids on HRV-induced exacerbations in pediatric asthma are unknown. We conducted a prospective observational study in inpatients aged 6–16 years with asthma exacerbations to investigate the effects of inhaled corticosteroids (ICS) on the detection rates of HRV species from nasopharyngeal samples and treatment periods of systemic corticosteroids on pulmonary lung function 3 months after exacerbations. Viral pathogens were identified in 45 out of 54 patients (83.3%) using multiplex PCR assay. HRV-A, -B, and -C were detected in 16 (29.6%), one (1.9%), and 16 (29.6%) patients, respectively. The detection rates of HRV-C were lower in the ICS-treated group compared with those in the ICS-untreated group (p = 0.01), whereas maintenance ICS did not affect the detection rate for viral pathogens in total and HRV-A. Changes in forced expiratory volume in one second predicted from baseline in patients treated with systemic corticosteroids for 6–8 days were higher than those in patients treated within 5 days (p = 0.0085). The protective effects of corticosteroids on virus-induced asthma exacerbations may be dependent upon the types of viral pathogen.
Interference Recommendation for the Pump Sizing Process in Progressive Cavity Pumps using Graph Neural Networks
Authors: Starke Leandro , Hoppe Aurélio Faustino , Sartori Andreza , Stefenon Stefano Frizzo , Leithardt Valderi Reis Quietinho 
Published: February 2023

Abstract
Pump sizing is the process of dimensional matching an impeller and stator to provide a satisfactory performance test result and good service life during the operation of progressive cavity pumps. In this process, historical data analysis and dimensional monitoring are done manually, consuming a large number of man-hours and requiring a deep knowledge of progressive cavity pump behavior. This paper proposes the use of graph neural networks in the construction of a prototype to recommend interference during the pump sizing process in a progressive cavity pump. For this, data from different expert applications were used in addition to individual control excel spreadsheets to build the database used in the prototype. From the pre-processed data, complex network techniques and the betweenness centrality metric were used to calculate the degree of importance of each order confirmation, as well as to calculate the dimensionality of the rotors. Using the proposed model a mean squared error of 0.28 was obtained for the cases where there were recommendations for order confirmations. Based on the results obtained, it was realized that there is a similarity with the dimensional defined by design engineers during the pump sizing process and this approach can be used to validate the project definitions.
Ethool, a tool to enable ethical and legal decision-making in research involving humans using new technologies in Europe: design and usability validation
Authors: Garzo Ainara , Garay-Vitoria Nestor 
Published: February 2023

Abstract
Human participation in technological research projects has become more frequent in recent years. However, most of the technological researchers who organize such experimentation are unaware about the various ethical and legal implications involved. Further, when it is a medical device prototype that is being evaluated, the ethical and legal implications may be even more complex. A review of the laws, standards and recommendations in Europe has been drawn up regarding human participation in new technology co-design, development and evaluation, focusing on technological research for assistive and medical devices. An easy-to-use tool, called Ethool, which acts as a guideline for European technological researchers has been designed and developed. In this manuscript, the iterative usability evaluation of Ethool is explained as well as the improvements made, following participants’ feedback. Ethool was rated as acceptable and usable by participants obtaining a SUS score of 93.0 in its last evaluation. The tool is currently available to be used by any interested parties with the aim of gathering additional feedback.
A route of polyethylene glycol-based phase change heat storage wood with AlN as the thermal conductive filler
Authors: Li Yanchen , Sun Jingmeng , Zhang Weiye , Fang Xiaoyang , Wang Beibei , Li Fangzhou , Zhang Daihui , Guo Hongwu , Liu Yi 
Published: February 2023

Abstract
Wood is a great potential natural material with good energy storage and temperature adjustment for the energy crisis. In this study, wood was delignified, and the PEG based eutectic polymer (PGMA) was impregnated into the delignified wood, and styrene (SM) grafted AlN was selected as thermal conductive filler to synthesize a stable phase change heat storage wood. The result shows that the styrene (SM) polymerized on the surface of AlN to form polystyrene (PS), the dispersion of AlN was enhanced. The thermal stability and loss resistance of PCES-Wood are improved for the penetration of PS-AlN into the cavities, which is attributed to the PS-AlN playing a "limiting" role in the crystallization of PGMA. When the content of PS-AlN is 6%, the thermal conductivity of PCES-Wood reaches 0.5148 W/(m·K). 4% PS-AlN-PCES@Balsa has the lowest undercooling and heat loss rate, and the melting enthalpy and solidification enthalpy reach 125.60 J/g and 120.30 J/g, respectively. The phase change temperature range is between 19.59 ℃ and 33.87 ℃, which is in the comfortable temperature range for the human. Under the illumination of the simulated solar light source, the surface temperature of PS-AlN-PCES@Balsa rises rapidly and shows a lasting heat storage capacity at low temperatures. After 200 cold and hot cycle tests, the phase change enthalpy of PS-AlN-PCES@Balsa is still high, and there is a slight leakage phenomenon. The phase-change wood prepared in this study shows that it is a potential material to store and release solar energy in practical applications.
Machine learning-based digital health application integrating wearable data and behavioral patterns improves metabolic health
Authors: Snyder Michael , McLaughlin Tracey , Zahedani Ashkan , Palmisano Salvator , Saberi Maziyar , Woodward Mark , Joselevitz Ronit , Ruan Jingyi , Romasko Heather , Agarwal Saransh , Tripathi Shital 
Published: February 2023

Abstract
Lifestyle interventions aimed at reducing caloric intake and increasing physical activity have the potential to prevent Type 2 Diabetes (T2D). The use of new technologies may enhance the success of lifestyle interventions, improve metabolic health, and prevent T2D. 2,217 participants, ranging from normoglycemic to T2D, were enrolled in the Season-of-Me Program in which glucose patterns were captured over 28 consecutive days via continuous glucose monitoring (CGM). Food intake, activity, and body weight were logged by participants and integrated with wearables data using a smartphone-based app which continuously provided insights to participants, including overlaying daily glucose patterns with activity and food intake, as well as summarizing macronutrient breakdown, glycemic index (GI), glycemic load, and activity measures. The mobile app also used machine learning to provide personalized recommendations based on users’ preferences, including their adherence to recommendations, their personal goals, and their glycemic patterns. Users had the option to continue interacting with the mobile app without CGM for an additional two months. Results demonstrated significant improvements in hyperglycemia, glucose variability, and hypoglycemia (particularly in those who were not diabetic at baseline). Body weight decreased in all groups, particularly in the most overweight/obese. Healthy eating habits improved significantly, with reduced daily caloric intake and proportion of carbohydrates-to-calories; and increased intake of protein, fiber, and healthy fats (relative to calories). These results suggest that integration of behavior logging and CGM data with AI-based personalized lifestyle recommendations can improve the metabolic health of both nondiabetic and T2D individuals via healthier lifestyle choices. This technology thus serves as an important tool to enhance current approaches to T2D prevention and treatment.
Meningitis-Retention Syndrome: a review and update of an unrecognized clinical condition
Authors: Pellegrino Francesco , Funiciello Elisa , Pruccoli Giulia , Silvestro Erika , Scolfaro Carlo , Mignone Federica , Tocchet Aba , Roasio Luca , Garazzino Silvia 
Published: February 2023

Abstract
Objectives: We summarized the clinical and radiological characteristics of Meningitis-Retention Syndrome (MRS), its therapeutic options and urological outcome, to better understand the pathogenesis of this syndrome and to evaluate the effectiveness of corticosteroids in reducing the period of urinary retention.
Methods: We reported a new case of MRS in a male adolescent. We also reviewed the previously 28 reported cases of MRS, collected from inception up to September 2022.
Results: MRS is characterized by aseptic meningitis and urinary retention. The mean length of the interval between the onset of the neurological signs and the urinary retention was 6.4 days. In most cases no pathogens were isolated in cerebrospinal fluid, except for 6 cases in which Herpesviruses were detected. The urodynamic study resulted in a detrusor underactivity, with a mean period for urination recovery of 4.5 weeks, regardless of therapies.
Discussion: Neurophysiological studies and electromyographic examination are not pathological, distinguishing MRS from polyneuropathies. Although there are no encephalitic symptoms or signs, and the magnetic resonance is often normal, MRS may represent a mild form of acute disseminated encephalomyelitis, without radiological detectable medullary involvement, due to the prompt use of steroids. It is believed that MRS is a self-limited disease, and no evidence suggests the effectiveness of steroids, antibiotics, and antiviral treatment in its clinical course.
What drives phylogenetic and trait clustering on islands?
Authors: Zhang Aiying , Cadotte Marc W. , Wu Donghao , Yu Mingjian 
Published: February 2023

Abstract
Context
As one primary catchment-scale impacts of dam constructions on ecosystems, fragmentation, resulting in reduced species richness, altered ecological processes and degraded ecosystem functioning, has been increasing intensely.
Objectives
Explore the drivers that hinder species co-existence and community assembly would facilitate understanding the fragmentation effect caused by dams.
Methods:
We hypothesized that habitat filtering and competitive exclusion can simultaneously drive community assembly processes, such that communities on small islands, where competition for limited space and resources is more intense, would be functionally and phylogenetically less clustered than those on large islands. We used ten functional traits and a phylogeny of 76 woody plant species to assess species diversity and similarity within communities across an island area gradient.
Results
As expected, species were more phylo-functionally similar to one another than expected by chance within islands and this underdispersion grew stronger with island area, indicating that while islands contained clustered communities, habitat filtering and competitive exclusion were both likely occurring. By integrating species abundance distributions with community similarity, we found that the most abundant species were phylo-functionally similar to the least abundant species. Species richness increased with island area, as expected, but the additional species found only on large islands tended to have low abundances, providing opportunities for rare species to persist.
Conclusions
With habitat filtering narrowing the number of species that can persist, the loss of phylo-functionally closely related rare species on small islands was likely caused by competition or stochastic removals, leading to greater species dissimilarity than on large islands. On large islands, the clustered patterns are likely to be the result of a combination of competitive exclusion caused by resource limitation and from habitat filtering.
Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment
Authors: Liu Shuying , Xie Shelly M. , Liu Wenbin , Gagea Mihai , Hanker Ariella B. , Nguyen Nguyen , Raghavendra Akshara Singareeka , Yang-Kolodji Gloria , Chu Fuliang , Neelapu Sattva S. , Hanash Samir , Zimmermann Johann , Arteaga Carlos L. , Tripathy Debasish 
Published: February 2023

Abstract
Background: Although trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or amplified (HER2+) breast cancer, a significant proportion of patients do not respond or eventually develop clinical resistance. Strategies to reverse trastuzumab resistance remain a high clinical priority. We were the first to report the role of CXCR4 in trastuzumab resistance. The present study aims to explore the therapeutic potential of targeting CXCR4 and better understand the associated mechanisms.
Methods: Immunofluorescent staining, confocal microscopy analysis, and immunoblotting were used to analyze CXCR4 expression. BrdU incorporation assays and flow cytometry were used to analyze dynamic CXCR4expression. Three-dimensional co-culture (tumor cells/ breast cancer-associated fibroblasts / human peripheral blood mononuclear cells) or antibody-dependent cellular cytotoxicity assay was used to mimic human tumor microenvironment, which is necessary for testing therapeutic effect of CXCR4 inhibitor or trastuzumab. The FDA-approved CXCR4 antagonist AMD3100, trastuzumab, and docetaxel chemotherapy were used to evaluate therapeutic efficacy in vitro and in vivo. Reverse phase protein array and immunoblotting were used to discern the associated molecular mechanisms.
Results: Using multiple cell lines and patient breast cancer samples we confirmed CXCR4 drives trastuzumab resistance in HER2+ breast cancer and further demonstrated that the increased CXCR4 expression in trastuzumab-resistant cells is associated with cell cycle progression with a peak in the G2/M phases. Blocking CXCR4 with AMD3100 inhibits cell proliferation by downregulating mediators of G2-M transition, leading to G2/M arrest and abnormal mitosis. Using multiple trastuzumab-resistant cell lines and an in vivo established trastuzumab-resistant xenograft mouse model, we demonstrated that targeting CXCR4 with AMD3100 suppresses tumor growth in vitro and in vivo, and synergizes with docetaxel.
Conclusions: Our findings support CXCR4 as a novel therapeutic target and a predictive biomarker for trastuzumab resistance in HER2+ breast cancer.
Comparison of short-term surgical outcomes and long-term survival between emergency and elective surgery for colorectal cancer: A systematic review and meta-analysis
Authors: Zhou Haiyan , Jin Yongyan , Wang Jun , Chen Guofeng , Chen Jian , Yu Shaojun 
Published: February 2023

Abstract
Objective: The objective of this study was to summarize relevant data from previous reports and perform a meta-analysis to compare short-term surgical outcomes and long-term oncological outcomes between emergency and elective surgery for colorectal cancer(CRC).
Methods: A systematic literature search was performed using PubMed and Embase databases and relevant data were extracted. Postoperative morbidity, hospital mortality within 30 days, postoperative recovery, overall survival(OS) and relapse-free survival(RFS) were compared using a fixed or random-effect model.
Results: 28 studies involving 353,686 participants were enrolled for this systematic review and meta-analysis, and 23.5%(83,054/353,686) of CRC patients underwent emergency surgery. The incidence of emergency presentations in CRC patients ranged from 2.7% to 38.8%. Lymph node yield of emergency surgery was comparable to that of elective surgery(WMD:0.70, 95%CI:-0.74,2.14, P=0.340; I2=80.6%). Emergency surgery had a higher risk of postoperative complications(OR:1.83, 95%CI:1.62-2.07, P<0.001; I2=10.6%) and hospital mortality within 30 days(OR:4.62, 95%CI:4.18-5.10, P<0.001; I2=42.9%) than elective surgery for CRC. In terms of long-term oncological outcomes, emergency surgery was significantly associated with poorer RFS (HR: 1.51, 95%CI:1.24-1.83, P<0.001; I2=58.9%) and OS(HR:1.60, 95%CI: 1.47-1.73, P<0.001; I2=63.4%) of CRC patients. In addition, the subgroup analysis for colon cancer patients revealed a pooled HR of 1.73 for OS(95% CI:1.52-1.96, P<0.001), without the evidence of significant heterogeneity(I2=21.2%).
Conclusion: Emergency surgery for CRC had an adverse impact on short-term surgical outcomes and long-term survival. A focus on early screening programs and health education were warranted to reduce emergency presentations of CRC patients.
Legume intake and cancer risk in a network of case-control studies
Authors: Patel Linia , Patel Linia , Vecchia Carlo La , Negri Eva , Mignozzi Silvia , Augustin Livia , Levi Fabio , Serraino Diego , Giacosa Attilio , Alicandro Gianfranco 
Published: February 2023

Abstract
Evidence on the relationship between legume consumption and risk of specific cancer sites is inconclusive. We used data from a network of case-controls studies, conducted in Italy and in the Swiss Canton of Vaud between 1991 and 2009 to quantify the association between legume consumption and several cancer sites including oral cavity, esophagus, larynx, stomach, colorectum, breast, endometrium, ovary, prostate and kidney. Multiple logistic regression models controlled for sex, age, education, smoking, alcohol, body mass index and consumption of fruit, vegetables, processed meat and total calorie intake were used to estimate the odds ratios (OR) of different cancer sites and their corresponding 95% confidence intervals(CI). For female hormone-related cancers, the models included also adjustments for age at menarche, menopausal status and parity. For all cancer sites considered, except endometrium, the OR for ≥ 2 portions of legumes per week vs < 1 portion were below unity, and were significant for oral cavity (OR: 0.71, 95% CI: 0.52–0.97), esophagus (OR: 0.50, 95% CI: 0.29–0.86), larynx (OR: 0.55, 95% CI: 0.34–0.89), colorectum (OR: 0.70, 95% CI: 0.58–0.83) and kidney (OR: 0.69, 95% CI: 0.49–0.95). For esophagus, colorectal, ovarian and kidney cancers we found a significant trend (OR for 1 portion per week: 0.82,0.88, 0.89 and 0.88 respectively. The analysis stratified by sex showed that most associations were limited to men. The inverse association found for several cancers suggest a possible role of legumes in preventing cancer risk. The sex-specific pattern of association requires further research.
Graph theoretical description of phase transitions in nanoscale assemblies of surfactants
Authors: Yang Ruochen , Bernardino Kalil , Xiao Xiongye , Gomes Weverson R. , Mattoso Davi A. , Kotov Nicholas A. , Bogdan Paul , de Moura André F. 
Published: February 2023

Abstract
Phase transitions are typically quantified using order parameters, such as crystal lattice distances, Legendre polynomials, and radial distribution functions (RDF). These parameters can identify even subtle changes in packing distances and symmetries, being ideally suited for crystalline materials or high-contrast phases with large structural differences. However, the structural changes are more difficult to quantify when the organizational pattern of constituent molecules becomes less ordered and more complex. This is the case for phases with high asymmetry and multiscale organization as well as for the structural fluctuations preceding phase transitions, which areessential for understanding the system pathways between phases. Here, we show that graph theoretical (GT) descriptors can successfully characterize different phases and pathways between them for hierarchically organized nanoscale systems exemplified by binary surfactant/water systems. We found that the GT centrality parameters and node-based fractal dimension can successfully identify complex phases more accurately than traditional analyses and quantify the system behavior preceding the transitions. The trajectories for GT parameter of closeness centrality reflect (1) fluctuation-induced breakup of micelles and (2) long-range cooperative interactions in the network of surfactant molecules. GT parametrization can be generalized for a wide range of nanoscale colloidal systems, which can facilitate identification of complex phases and engineer nanostructures at multiple scales.
RETRACTED: Effects of tocilizumab and dexamethasone on proinflammatory cytokines and antioxidants in acute kidney injury caused by oleic acid-induced ARDS
Authors: Erol Huseyin Serkan , Demirci Beste , Alhilal Mohammad , Terzi Funda 
Published: February 2023

Abstract
The authors have requested that this preprint be removed from Research Square.