bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated MINFLUX Nanoscopy, through Spontaneously Fast‐Blinking Fluorophores
Authors: Remmel Michael , Scheiderer Lukas , Butkevich Alexey N. , Bossi Mariano L. , Hell Stefan W. 
Published: January 2023

AbstractThe introduction of MINFLUX nanoscopy allows single molecules to be localized with one nanometer precision in as little as one millisecond. However, current applications have so far focused on increasing this precision by optimizing photon collection, rather than minimizing the localization time. Concurrently, commonly used fluorescent switches are specifically designed for stochastic methods (e.g., STORM), optimized for a high photon yield and rather long on‐times (tens of milliseconds). Here, accelerated MINFLUX nanoscopy with up to a 30‐fold gain in localization speed is presented. The improvement is attained by designing spontaneously blinking fluorescent markers with remarkably fast on‐times, down to 1–3 ms, matching the iterative localization process used in a MINFLUX microscope. This design utilizes a silicon rhodamine amide core, shifting the spirocyclization equilibrium toward an uncharged closed form at physiological conditions and imparting intact live cell permeability, modified with a fused (benzo)thiophene spirolactam fragment. The best candidate for MINFLUX microscopy (also suitable for STORM imaging) is selected through detailed characterization of the blinking behavior of single fluorophores, bound to different protein tags. Finally, optimization of the localization routines, customized to the fast blinking times, renders a significant speed improvement on a commercial MINFLUX microscope.
Superior Performances of Self‐Driven Near‐Infrared Photodetectors Based on the SnTe:Si/Si Heterostructure Boosted by Bulk Photovoltaic Effect
Authors: Zhong Aihua , Zhou Yue , Jin Hao , Yu Huimin , Wang Yunkai , Luo Jingting , Huang Longbiao , Sun Zhenhua , Zhang Dongping , Fan Ping 
Published: January 2023

AbstractThe upsurge of new materials that can be used for near‐infrared (NIR) photodetectors operated without cooling is crucial. As a novel material with a small bandgap of ≈0.28 eV, the topological crystalline insulator SnTe has attracted considerable attention. Herein, this work demonstrates self‐driven NIR photodetectors based on SnTe/Si and SnTe:Si/Si heterostructures. The SnTe/Si heterostructure has a high detectivity D* of 3.3 × 1012 Jones. By Si doping, the SnTe:Si/Si heterostructure reduces the dark current density and increases the photocurrent by ≈1 order of magnitude simultaneously, which improves the detectivity D* by ≈2 orders of magnitude up to 1.59 × 1014 Jones. Further theoretical analysis indicates that the improved device performance may be ascribed to the bulk photovoltaic effect (BPVE), in which doped Si atoms break the inversion symmetry and thus enable the generation of additional photocurrents beyond the heterostructure. In addition, the external quantum efficiency (EQE) measured at room temperature at 850 nm increases by a factor of 7.5 times, from 38.5% to 289%. A high responsivity of 1979 mA W−1 without bias and fast rising time of 8 µs are also observed. The significantly improved photodetection achieved by the Si doping is of great interest and may provide a novel strategy for superior photodetectors.
High Thermal Conductivity of Sandwich‐Structured Flexible Thermal Interface Materials
Authors: Jing Lin , Cheng Rui , Tasoglu Muzaffer , Wang Zexiao , Wang Qixian , Zhai Hannah , Shen Sheng , Cohen‐Karni Tzahi , Garg Raghav , Lee Inkyu 
Published: January 2023

AbstractThermal interfaces are vital for effective thermal management in modern electronics, especially in the emerging fields of flexible electronics and soft robotics that impose requirements for interface materials to be soft and flexible in addition to having high thermal performance. Here, a novel sandwich‐structured thermal interface material (TIM) is developed that simultaneously possesses record‐low thermal resistance and high flexibility. Frequency‐domain thermoreflectance (FDTR) is employed to investigate the overall thermal performance of the sandwich structure. As the core of this sandwich, a vertically aligned copper nanowire (CuNW) array preserves its high intrinsic thermal conductivity, which is further enhanced by 60% via a thick 3D graphene (3DG) coating. The thin copper layers on the top and bottom play the critical roles in protecting the nanowires during device assembly. Through the bottom‐up fabrication process, excellent contacts between the graphene‐coated CuNWs and the top/bottom layer are realized, leading to minimal interfacial resistance. In total, the thermal resistance of the sandwich is determined as low as ~0.23 mm2 K W−1. This work investigates a new generation of flexible thermal interface materials with an ultralow thermal resistance, which therefore renders the great promise for advanced thermal management in a wide variety of electronics.
Oriented Assembled Prussian Blue Analogue Framework for Confined Catalytic Decomposition of Ammonium Perchlorate
Authors: Zhou Peng , Tang Xiaolin , Ren Zhuoqun , Zheng Zeyu , Zhang Kuan , Zhou Rui , Wu Dan , Liao Jun , Zhang Yifu , Huang Chi 
Published: January 2023

AbstractThe design of highly dispersed active sites of hollow materials and unique contact behavior with the components to be catalyzed provide infinite possibilities for exploring the limits of catalyst capacity. In this study, the synthesis strategy of highly open 3‐dimensional frame structure Prussian blue analogues (CoFe‐PBA) was explored through structure self‐transformation, which was jointly guided by template mediated epitaxial growth, restricted assembly and directional assembly. Additionally, good application prospect of CoFe‐PBA as combustion catalyst was discussed. The results show that unexpected thermal decomposition behavior can be achieved by limiting AP(ammonium perchlorate) to the framework of CoFe‐PBA. The high temperature decomposition stage of AP can be advanced to 283.6 °C and the weight loss rate can reach 390.03% min−1. In‐situ monitoring shows that CoFe‐PBA can accelerate the formation of NO and NO2. The calculation of reaction kinetics proved that catalytic process was realized by increasing the nucleation factor. On this basis, the catalytic mechanism of CoFe‐PBA on the thermal decomposition of AP was discussed, and the possible interaction process between AP and CoFe‐PBA during heating was proposed. At the same time, another interesting functional behavior to prevent AP from caking was discussed.
Monodispersed Pt Sites Supported on NiFe‐LDH from Synchronous Anchoring and Reduction for High Efficiency Overall Water Splitting
Authors: Huo Jia‐Min , Ma Ze‐Lin , Wang Ying , Cao Yi‐Jia , Jiang Yu‐Cheng , Li Shu‐Ni , Chen Yu , Hu Man‐Cheng , Zhai Quan‐Guo 
Published: January 2023

AbstractPrecise design of low‐cost, efficient and definite electrocatalysts is the key to sustainable renewable energy. Herein, this work develops a targeted‐anchored and subsequent spontaneous‐redox strategy to synthesize nickel‐iron layered double hydroxide (LDH) nanosheets anchored with monodispersed platinum (Pt) sites (Pt@LDH). Intermediate metal‐organic frameworks (MOF)/LDH heterostructure not only provides numerous confine points to guarantee the stability of Pt sites, but also excites the spontaneous reduction for PtII. Electronic structure, charge transfer ability and reaction kinetics of Pt@LDH can be effectively facilitated by the monodispersed Pt moieties. As a result, the optimized Pt@LDH that with the 5% ultra‐low content Pt exhibits the significant increment in electrochemical water splitting performance in alkaline media, which only afford low overpotentials of 58 mV at 10 mA cm−2 for hydrogen evolution reaction (HER) and 239 mV at 10 mA cm−2 for oxygen evolution reaction (OER), respectively. In a real device, Pt@LDH can drive an overall water‐splitting at low cell voltage of 1.49 V at 10 mA cm−2, which can be superior to most reported similar LDH‐based catalysts. Moreover, the versatility of the method is extended to other MOF precursors and noble metals for the design of ultrathin LDH supported monodispersed noble metal electrocatalysts promoting research interest in material design.
Stimuli‐Triggered Multishape, Multimode, and Multistep Deformations Designed by Microfluidic 3D Droplet Printing
Authors: Yang Chenjing , Xiao Yao , Hu Lingjie , Chen Jingyi , Zhao Chun‐Xia , Zhao Peng , Ruan Jian , Wu Ziliang , Yu Haifeng , Weitz David A , Chen Dong 
Published: January 2023

AbstractElastomers generally possess low Young's modulus and high failure strain, which are widely used in soft robots and intelligent actuators. However, elastomers generally lack diverse functionalities, such as stimulated shape morphing, and a general strategy to implement these functionalities into elastomers is still challenging. Here, a microfluidic 3D droplet printing platform is developed to design composite elastomers architected with arrays of functional droplets. Functional droplets with controlled size, composition, position, and pattern are designed and implemented in the composite elastomers, imparting functional performances to the systems. The composited elastomers are sensitive to stimuli, such as solvent, temperature, and light, and are able to demonstrate multishape (bow‐ and S‐shaped), multimode (gradual and sudden), and multistep (one‐ and two‐step) deformations. Based on the unique properties of droplet‐embedded composite elastomers, a variety of stimuli‐responsive systems are developed, including designable numbers, biomimetic flowers, and soft robots, and a series of functional performances are achieved, presenting a facile platform to impart diverse functionalities into composite elastomers by microfluidic 3D droplet printing.
Development of a laparoscopic technique for inguinal hernioplasty in standing horses
Authors: Vitoria Arantza , Romero Antonio , Barrachina Laura , Fuente Sara , Gil Lydia , de Blas Ignacio , Vázquez Bringas Francisco José 
Published: January 2023

ABSTRACTBackgroundMost previously described techniques for laparoscopic inguinal hernioplasty (IH) in horses require advanced laparoscopic skills. Our objective was to describe a new laparoscopic IH technique using a surgical anchoring system.MethodsStanding laparoscopic IH was performed unilaterally in eight experimental stallions, using the contralateral inguinal canal (IC) as a control. A polyether ether ketone harpoon was anchored in the craniolateral aspect of the vaginal ring, and an extracorporeal knot was used to fix the device. Clinical evaluation, including testicular palpation and lameness examination, was conducted before and for 4 weeks after surgery. Repeat laparoscopy was performed 28 days later.ResultsStanding laparoscopic IH was performed in all horses with a surgical time of 38 ± 12.85 minutes. In two animals, a small peritoneal tear occurred that did not require repair. No other complications were recorded. On repeat laparoscopy, all devices were in place, and the IC remained partially closed in all horses.LimitationsThe procedure was performed on normal experimental horses and has not been employed on horses that have had an inguinal hernia.ConclusionsThis new standing laparoscopic hernioplasty technique provides another potential method for simple partial closure of the IC in stallions at risk of or with history of inguinal herniation.
Does colonization with MRSA, ESBL – producingEnterobacteriaceae, and/orAcinetobacter baumannii– increase the risk for postoperative surgical site infection?
Authors: Gehlen Heidrun , Klein Katja‐Sophia , Merle Roswitha , Lübke‐Becker Antina , Stoeckle Sabita D. 
Published: January 2023

AbstractObjectiveEvaluation of the role of indicator pathogens in equine surgical site infection (SSI) and other infection‐promoting factors.Study designCross‐sectional study.AnimalsHorses presenting with an open injury or surgical colic during 1.5 years.MethodsA nasal swab and a faecal sample were collected from every patient upon admission. Furthermore, a wound swab was collected from wounds of injured horses. Details on the wounds and procedures were documented. Laparotomy incisions and injuries were monitored for signs suggesting infection.ResultsIn total, 156 horses presented because of a surgical colic (n = 48) or open injuries (n = 108). Thirteen surgical colic patients and three injured horses did not survive beyond 24 h, and four injured horses were discharged from the clinic at the day of admission. SSIs occurred in 31 (30.7%) injured horses and 11 (31.4%) horses after laparotomy. Regarding injuries, general anaesthesia increased the risk of developing a WI compared to sedation. Indicator pathogens were cultured from 29/42 SSI. In total, 10/11 infected laparotomy incisions and 19/31 injuries with SSI tested positive for multidrug‐resistant pathogens (MDRPs) . Indicator pathogens were not detected at admission in any of the horses that developed incisional SSIs after laparotomy but were detected in two of the injured horses that developed SSIs.ConclusionMDRPs were identified in almost 70% of the SSI. Less than 5% of the affected animals were colonized with the same pathogen before admission, indicating that colonization with MDR pathogens is only one of the crucial factors for the development of SSI.Clinical significanceColonization with MDRP seems not to predispose horses to MDR SSIs.
The linear symmetries of Hill’s lunar problem
Authors: Aydin Cengiz 
Published: January 2023

AbstractA symmetry of a Hamiltonian system is a symplectic or anti-symplectic involution which leaves the Hamiltonian invariant. For the planar and spatial Hill lunar problem, four resp. eight linear symmetries are well-known. Algebraically, the planar ones form a Klein four-group$${\mathbb {Z}}_2 \times {\mathbb {Z}}_2$$Z2×Z2and the spatial ones form the group$${\mathbb {Z}}_2 \times {\mathbb {Z}}_2 \times {\mathbb {Z}}_2$$Z2×Z2×Z2. We prove that there are no other linear symmetries. Remarkably, in Hill’s system the spatial linear symmetries determine already the planar linear symmetries.
Research methods in engineering design: a synthesis of recent studies using a systematic literature review
Authors: Escudero-Mancebo David , Fernández-Villalobos Nieves , Martín-Llorente Óscar , Martínez-Monés Alejandra 
Published: January 2023

AbstractThe relation between scientific research and engineering design is fraught with controversy. While the number of academic PhD programs on design grows, because the discipline is in its infancy, there is no consolidated method for systematically approaching the generation of knowledge in this domain. This paper reviews recently published papers from four top-ranked journals in engineering design to analyse the research methods that are frequently used. The research questions consider the aim and contributions of the papers, as well as which experimental design and which sources of data are being used. Frequency tables show the high variety of approaches and aims of the papers, combining both qualitative and quantitative empirical approaches and analytical methods. Most of the papers focus on methodological concerns or on delving into a particular aspect of the design process. Data collection methods are also diverse without a clear relation between the type of method and the objective or strategy of the research. This paper aims to act as a valuable resource for academics, providing definitions related to research methods and referencing examples, and for researchers, shedding light on some of the trends and challenges for current research in the domain of engineering design.
A novel anchoring system for pelvic organ prolapse repair: an observational study
Authors: van Raalte Heather , Bhatia Nina , Mangel Jeffrey , Ryckebusch Hugo , Roovers Jan-Paul 
Published: January 2023

Abstract
Introduction and hypothesis
Sacrospinous ligament (SSL) fixation is an effective and widely used vaginal procedure for correcting apical prolapse. The Saffron Fixation System (Coloplast Corp., Minneapolis, MN, USA) is a new anchoring device aimed at facilitating a durable, easy, and short procedure for SSL fixation with the goal of minimizing operative complications. The objective was to demonstrate the efficacy and safety of anchor deployment and suture fixation for pelvic organ prolapse repair using the Saffron Fixation System.

Methods
An observational human cadaver study was conducted to measure the distance between anchor location and anatomical landmarks in the pelvis, and the holding force of the fixated anchors. Anchors were placed in four human cadavers by different implanters. The pull-out force of these anchors was measured to assess efficacy (three cadavers by three implanters) and the distance between anchors and primal vessels and nerves was measured to assess safety (one cadaver by one implanter).

Results
Nineteen out of 20 anchors (95%) were correctly placed as judged by independent assessment performed by non-implanting surgeons. Distance between anchors and surrounding nerves and vessels exceeded 10 mm. Mean (SD) pull out-force was 17.9 (5.6) N.

Conclusion
The innovative anchoring device that was developed appeared to enable precise and solid anchor placement in the SSL. Future clinical studies are needed to explore if the theoretical advantages of this device translate to improved clinical outcomes in comparison with available suturing and anchoring devices.
Shorter duration of venetoclax administration to 14 days has same efficacy and better safety profile in treatment of acute myeloid leukemia
Authors: Aiba Masayuki , Shigematsu Akio , Suzuki Toma , Miyagishima Takuto 
Published: January 2023

AbstractVenetoclax (VEN) is now widely used in the treatment of acute myelogenous leukemia (AML) in elderly patients who are not eligible for intensive remission induction therapy. Prolonged myelosuppression, increased incidence of infection, and long duration of hospital stay were major concerns for VEN treatment cases, and we thought that shortening the duration of VEN administration during induction therapy might solve these problems. Thirteen newly diagnosed AML patients who underwent VEN+azacitidine (AZA) induction therapy from March 2021 to June 2022 at Kushiro Rosai Hospital were analyzed retrospectively. The median age was 79 (range, 68–86) years, and 8 of the patients (61.5%) were classified as high risk according to the ELN 2017 risk stratification. Eight patients received VEN for 14 days (VEN14 group), and 5 patients received VEN for 28 days (VEN28 group). The composite complete remission (CRc) rate was 76.9% in total, and the CRc rates in the VEN14 and VEN28 groups were almost the same (75.0% and 80.0%, respectively). The median overall survival (OS) was not reached in the VEN14 group and was 254 days in the VEN28 group. The median event-free survival (EFS) was not reached in the VEN14 group and was 178 days in the VEN28 group. The VEN14 group might have a possibility to reduce febrile neutropenia (37.5% vs. 80%) and reduce the duration of hospital stay (median, 21.5 vs. 31 days) compared with the VEN28 group. VEN14 produced the same CRc rate and survival rate, safer profile, and shorter duration of hospital stay than VEN28.
Synthesis, crystal structure and dielectric properties of a hybrid dihydrogen arsenate salt: (C9H11N4)H2AsO4
Authors: Kammoun Omar , Abdelhedi Mohamed , Boujelbene Mohamed 
Published: January 2023

AbstractThe use of the organic aromatic amine molecule 5-amino-3-methyl-1-phenyl-1H-1,2,4-triazole to synthesize a dihydrogen arsenate hybrid salt leads to a supramolecular structure type. Single crystals of (C9H11N4)H2AsO4 were grown through slow evaporation in solution. The synthesized compound crystallizes in the monoclinic system with the non-centrosymmetric P21 space group according to the following parameters; a = 9.655 (3) Å, b = 4.7090 (15) Å, c = 14.022 (4) Å, β = 108.147 (5)° and Z = 4. The mineral part building from dihydrogen arsenate anions [H2AsO4]− is linked together and to the organic cations [C9H11N4]+ by hydrogen bonds only. The results of Hirshfeld’s analysis show that in all possible molecular contacts, the hydrogen–hydrogen and the oxygen–hydrogen are the most important interaction in the crystal (37.5 and 31.9%, respectively). The Fourier transform infrared (FT-IR) confirms the existence of vibrational modes corresponding to the organic amine molecule and mineral arsenate tetrahedron. The optimized molecular structure and the vibrational spectra were calculated by the density functional theory DFT methods and the semi-empirical PM3 calculations. Dielectric study of this compound has been measured in order to determine the electrical conductivity type giving rise to an activation energy of ΔEσ = 0.17 eV.
Characteristics and outcomes of patients undergoing transcatheter mitral valve replacement with the Tendyne system
Authors: Wilde Nihal , Tanaka Tetsu , Vij Vivian , Sugiura Atsushi , Sudo Mitsumasa , Eicheler Eva , Silaschi Miriam , Vogelhuber Johanna , Bakhtiary Farhad , Nickenig Georg , Weber Marcel , Zimmer Sebastian 
Published: January 2023

Abstract
Background
Transcatheter mitral valve replacement (TMVR) has emerged as alternative to transcatheter edge-to-edge repair (TEER) for treatment of mitral regurgitation (MR); however, the role of TMVR with the Tendyne system among established treatments of MR is not well defined. We assessed characteristics and outcomes of patients treated with the Tendyne system in the current clinical practice.

Methods
We reviewed patients who underwent cardiac computed tomography and were judged eligible for the Tendyne system.

Results
A total of 63 patients were eligible for TMVR with the Tendyne system. Of these, 17 patients underwent TMVR, and 46 were treated by TEER. Patients treated with the Tendyne system were more likely to have a high transmitral pressure gradient and unsuitable mitral valve morphology for TEER than those treated with TEER. TMVR with the Tendyne system reduced the severity of MR to less than 1 + in 94.1% of the patients at discharge and achieved a greater reduction in left ventricular (LV) end-diastolic volume at the 30-day follow-up compared with TEER. In contrast, patients treated with the Tendyne system had a higher 30-day mortality than those treated with TEER, while the mortality between 30 days and one year was comparable between Tendyne and TEER.

Conclusions
Among patients eligible for the Tendyne system, approximately a quarter of the patients underwent TMVR with the Tendyne system, which led substantial reduction of MR and LV reverse remodeling than TEER. In contrast, the 30-day mortality rate was higher after TMVR with the Tendyne compared to TEER.