bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank
Authors: Brooks Thomas , Lahens Nicholas , Grant Gregory , Sheline Yvette , FitzGerald Garret , Skarke Carsten 
Published: February 2023

Abstract
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which are well-established biomarkers for circadian clock function. Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6,728) compared to controls (range n = 62,107 − 91,134), a total of 73 (36.5%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q < 0.05) and 26 (13%) PheCODEs passed a more stringent significance level (Bonferroni-correction α < 0.05). Here, for example, a two-standard deviation (1.8° Celsius) lower wrist temperature amplitude corresponded to hazard ratios of 1.91 (1.58–2.31 95% CI) for NAFLD, 1.69 (1.53–1.88) for type 2 diabetes, 1.25 (1.14–1.37) for renal failure, 1.23 (1.17–1.3) for hypertension, and 1.22 (1.11–1.33) for pneumonia. A comprehensive phenome-wide atlas of the identified mappings has been made available at http://bioinf.itmat.upenn.edu/biorhythm_atlas/. These findings strongly suggest peripheral thermoregulation as a digital biomarker.
Regeneration Potential of Mesenchymal Stem Cells in Cold Induced Burn Wounds
Authors: Jameel Fatima , Khan Irfan , Malick Tuba Shakil , Qazi Rida-e-Maria , Zaidi Midhat Batool , Khalid Shumaila , Salim Asmat , Aslam Shazmeen , Khalil Enam A. 
Published: February 2023

Abstract
Background: Time-dependent initiation of wound healing phases and their associated healing mediators are crucial for injured skin regeneration. Mesenchymal stem cells (MSCs) secrete various paracrine factors which aid in wound healing via acceleration of cell migration, angiogenesis, tissue granulation, and modulation of inflammation at the wound site.
Objective: This study was aimed to investigate thetherapeutic effect of human umbilical cord MSCs (hUCMSCs) in the regeneration of cold-induced burn wound model.
Methods: hUCMSCs were characterized by immunocytochemistry and flow cytometry. Scratch assay was performed using rat skin fibroblasts treated with conditioned medium of hUCMSCs. An in vivo cold burn wound model was developed and hUCMSCs were locally transplanted. Macroscopic analysis of wound closure was done at days 1, 3, 7 and 14 corresponding to wound healing phases. Gene expression, histology and immunohistochemical analysis were performed to confirm complete wound repair.
Results: We observed a significant reduction in the scratch area in the treated group as compared to the control. Wound area was remarkably reduced in the burn wound model transplanted with hUCMSCs well before the end of the experimental period (day 14). Histology showed intact collagen with regenerated epidermis, dermis and hair follicles, while immunohistochemistry showed enhanced angiogenesis in the last phase of healing in the treated group. Temporal gene expression showed significant reduction in inflammatory cytokines and upregulation of pro/angiogenic and remodeling cytokines at particular time points.
Conclusion: It is concluded from this study that hUCMSCs accelerate wound closure with enhanced neovascularization and reduced inflammation in rat dermal wounds.
Racial Disparities in Quantitative MRI for African American and White Men with Prostate Cancer
Authors: Zabihollahy Fatemeh , Miao Qi , Sonni Ida , Vangala Sitaram , Kim Harrison , Hsu William , Sisk Anthony , Reiter Robert , Raman Steven , Sung Kyunghyun 
Published: February 2023

Abstract
The risk of prostate cancer (PCa) is strongly influenced by race and ethnicity. The purpose of this study is to investigate differences in the diagnostic performance of multiparametric MRI (mpMRI) in African American (AA) and white (W) men. 111 patients (37 AA and 74 W men) were selected from the study's initial cohort of 885 patients after matching age, prostate-specific antigen, and prostate volume. The diagnostic performance of mpMRI was assessed using detection rates (DRs) and positive predictive values (PPVs) with/without combining Ktrans (volume transfer constant) stratified by prostate zones for AA and W sub-cohorts. The DRs of mpMRI for clinically significant PCa (csPCa) lesions in AA and W sub-cohort with PI-RADS scores ≥ 3 were 67.3% vs. 80.3% in the transition zone (TZ; p=0.026) and 81.2% vs. 76.1% in the peripheral zone (PZ; p>0.9). The Ktrans of csPCa in AA men was significantly higher than in W men (0.23±0.08 min-1 vs. 0.19±0.07 min-1 ; p=0.022). This emphasizes that there are race-related differences in the performance of mpMRI and quantitative MRI measures that are not reflected in age, PSA, and prostate volume.
Comparison of continuous flow analysis and ion chromatography for determinations of nitrate, nitrite and phosphate ions in seawater and development of related seawater certified reference materials
Authors: Cheong Chikako , Suzuki Toshihiro , Miura Tsutomu , Hioki Akiharu 
Published: February 2023

Abstract
Determinations of three nutrients (nitrate, nitrite and phosphate ions) in seawater were investigated by continuous flow analysis (CFA) based on colorimetry and ion chromatography (IC). The accuracies of those methods were examined by discussing their uncertainties. While CFA is popular in this field, its comparison with IC was reported for the first time and contributed to an increase in the reliability of the analytical results. Finally, the investigation led to the development of three kinds of seawater certified reference materials (CRMs) of the National Metrology Institute of Japan (NMIJ) (NMIJ CRM 7601-a, 7602-a and 7603-a) for which the property values of nutrients including dissolved silica were given. The details of the development are described in the present paper.
The relationship between family function and school belonging of junior high school students: the chain mediating roles between self-support and self-esteem
Authors: Xin Bin , Pang Lu , Shi Seqin , Peng Biao , Ouyang Min , yao zhendong 
Published: February 2023

Abstract
Background: This study examined the role of self-support and self-esteem in the chain mediating between family functioning and school belonging among Chinese junior high school students.
Methods:The questionnaire survey was used on 741 students from first to the third grade of junior high school students to collect data on the Family Function Scale, the Self-support Scale, the Self-Esteem Scale, and the School Belonging Scale. Mediating efect analysis was used to test the hypothesis.
Results: (1) there were statistically significant differences in family function, self-support, and school belonging by grade level; (2) there were significant positive correlations between family function, school belonging, self-esteem, and self-support in junior high school students; (3) self-support mediated the effect of family function on school belonging, and self-esteem mediated the effect of self-support on school belonging; (4) Self-support and self-esteem play a significant chain mediating role between family functioning and school belonging, with the mediating effect accounting for 8.53% of the total effect.
Conclusion: the family function could affect school belonging directly and indirectly through self-support and self-esteem.
Diarrhea Accompanies Intestinal Inflammation and Intestinal Mucosal Microbiota Dysbiosis during Fatigue Combined with a High-Fat Diet
Authors: Liu Jing , Qiao Bo , Cai Ying , Tan Zhoujin , Deng Na 
Published: February 2023

Abstract
Objective: It was reported fatigue or a high-fat diet triggers gastrointestinal (GI) disorders, and intestinal microbiota may play central roles in GI disorders. Therefore, we investigated the association between the intestinal mucosal microbiota and the intestinal mucosal barrier from fatigue combined with a high-fat diet.
Method: This study divided the Specific pathogen-free (SPF) male into the normal group (MCN) and the standing united lard group (MSLD). After establishing the model for 14 days, interleukin-6 (IL-6), interleukin-17 (IL-17), immunoglobulin A (sIgA), mucin 2 (Muc2), and intestinal mucosal microbiota were analyzed. Furthermore, the correlations between bacterial genera, inflammation, and immune function were measured.
Result: The pathological analysis proved obvious damage to the small intestinal structure after fatigue combined with a high-fat diet. MSLD mice presented an increased trend of IL-6 and IL-17 and a decreased tendency of sIgA and Muc2, aggravating the injury of the intestinal mucus barrier and GI symptoms. Fatigue combined with a high-fat diet considerably decreased Limosilactobacillus reuteri, positively associated with Muc2 and negatively with IL-6. Conclusion: The interactions between Limosilactobacillus reuteriand intestinal inflammation might be involved in the process of intestinal mucosal barrier impairment in fatigue combined with high-fat diet-induced diarrhea.
Omentopexy/Gastropexy (OP/GP) in Sleeve Gastrectomy Appears to Decrease the Incidence of Gastric Twist, Motility Related Complications, Leaks, and Bleeding. A Meta-Analysis of 17 Comparative Studies and a Plea for Routine OP/GP
Authors: Diab Abdul-Rahman Fadi , Alfieri Sarah , Deblieux Paige , Williams Ashley , Docimo Salvatore , Sujka Joseph Adam , DuCoin Christopher Garnet 
Published: February 2023

Abstract
Laparoscopic sleeve gastrectomy (LSG) can cause gastric twist/torsion, gastroesophageal reflux disease (GERD), and prolonged postoperative nausea and vomiting (PONV). In addition, bleeding and leaks are the most feared complications in the early postoperative period. Various staple line reinforcement (SLR) techniques have been innovated to reduce the incidence of bleeding and leaks; as oversewing (OS), omentopexy/gastropexy (OP/GP), buttressing, and gluing. OP/GP isn’t only an SLR method that is used for prevention of bleeding and leaks, but also a staple line fixation method that few surgeons use to prevent gastric twist/torsion, and motility related complications as GERD and prolonged PONV. The goal of this study is to compare postoperative outcomes between LSG with OP/GP and LSG without OP/GP or any other SLR method.
Key points
• OP/GP decreases, leaks, bleeding, readmissions, prolonged PONV, gastric twist/torsion, and GERD. This was consistent in all studies (no heterogeneity).
• OP/GP appears to decrease length of stay and prolonged antacids use at 12 months postoperatively, but this isn’t on solid ground due to significant heterogeneity observed among studies.
• The only disadvantage of OP/GP is the increase in operative time.
CONUT score to evaluate the prognosis of patients with cirrhosis complicated with esophageal and gastric variceal bleeding after initial endoscopic treatment
Authors: cai shanshan , Liu Jianguo , Cheng Bowen , Zhang Yulian , xie bushan 
Published: February 2023

Abstract
Objective:
The nutritional status of patients with liver cirrhosis complicated with EGVB controlled with initial endoscopic treatment in our hospital was evaluated according to the CONUT score. We compared the clinical data and prognosis of patients with different levels of nutritional status, and then investigated the role of CONUT score before endoscopic treatment on its prognosis.
Methods:
This is a retrospective study and obtain informed consent from all the study participants by telephone and wetchat.The patients diagnosed with liver cirrhosis complicated with Esophageal and gastric variceal bleeding (EGVB) in our hospital from April 2018 to November 2018 were retrospectively selected, and then controlled successfully by endoscopic operation. A total of 166 patients were included in this study. Patients were divided into two groups: the low CONUT score group and the high CONUT score group, based on the optimal cut-off points determined using receiver operating characteristic (ROC) analysis. The differences in baseline data, endoscopic data, treatment effects, and survival analysis were compared between the two groups of patients.
Conclusion
COUNT score affects prognosis of patients with EGVB.
IoT Platform Assessment methodology for COVID-19 Vaccine Logistics and Transportation: A Multi Methods Decision-Making Model
Authors: Ali Yasir Ali , Khan Habib Ullah Khan 
Published: February 2023

Abstract
The supply chain management (SCM) of COVID-19 vaccine is the most daunting task for logistics and supply managers due to temperature sensitivity and complex logistics process. Therefore, several technologies have been applied but, the complexity of COVID-19 vaccine makes the Internet of Things (IoT) a strong use case due to its multiple features support like excursion notification, data sharing, connectivity management, secure shipping, real-time tracking and monitoring etc. All these features can only feasible through choosing the right IoT platform. However, selection of right IoT platform is also a major concern due to lack of experience and technical knowledge of supply chain managers and diversified landscape of IoT platforms. Therefore, we introduce a decision making model for evaluation and decision making of IoT platforms that fits for logistics and transportation process of COVD-19 vaccine. This study identifies the major challenges addressed during the supply chain management of COVID-19 vaccine and then provides reasonable solution by presenting the assessment model for selection of rational IoT platform. The proposed model applies hybrid multi criteria decision making (MCDM) approach for evaluation. It also uses Estimation-talk-Estimation (ETE) approach for response collection and taxonomy of features. As, this is first kind of model so the proposed model is validated and tested by conducting a survey with experts. The results of the proposed decision making model are also verified by Simple Additive Weighting (SAW) technique.
Biosynthesis and evaluation of metallic nanoparticles (ZnO-NPs) using polyphenol- containing Ajuga macrosperma (Ghonke ghas) leafextract, along with anticancer activity and antimicrobial activity
Authors: Parveen Shama , Gupta Vikas , Wazzan Mohammad A. , Wazzan Huda , Abduljabbar Ahmed H. , Khan Waseem , Khan Anish , Yudhanto Ferriawan 
Published: February 2023

Abstract
Green chemistry is a relatively new discipline that promotes the use of a set of guidelines to decrease both the use of and the production of chemical waste. Accordingly, the use of environmentally friendly technology has a more beneficial effect on ecosystems than the use of factory workers. Plant extracts are seen as a greener and cheaper alternative to traditional methods of synthesizing metallic nanoparticles, and their usage is on the rise. In this study, an aqueous leaf extract of Ajuga macrosperma was used to biosynthesize metallic Zinc oxide nanoparticles. There is a limiting and capping effect caused by plants. Ultraviolet spectrophotometric analysis was used to monitor the biosynthesized nanoparticles in real-time. The incorporation of leaf extract resulted in a noticeable hue shift, which allowed for the visual detection of the creation of metallic nanoparticles. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive X-ray spectroscopy (EDX), and zeta potential were all used to learn more about the nanoparticles. The SEM scan reveals that the nanoparticles have a spherical form and measure between 10 and 100 nm in size. The XRD analysis verified that the synthetic ZnONPs have a Wurtzite crystalline structure. Results from FTIR and EDAX analysis reveal the nanoparticles' functional groups and elemental makeup. MTT assay was used to test the anticancer activity of A. macrosperma leaves in MCF-7 (breast cancer), HeLa (human embryonic lung cancer), PC-3 (prostate cancer), and A549 (lung cancer). Additionally, research has also shown that produced ZnONPs are highly active against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Escherichia coli. as well as against yeast (Candida albicans) showing no efficacy.
Artificial Intelligence Based Chatbots to Combat COVID-19 Pandemic: A Scoping Review
Authors: Mahdavi Abdollah , Amanzadeh Masoud , Hamedan Mahnaz , Naemi Roya 
Published: February 2023

Abstract
Background: Artificial intelligence (AI) Chatbots are computer programs that simulate human conversation and use artificial intelligence including machine learning and natural language processing to interact with users via natural language. With the outbreak of the COVID-19 pandemic, the use of digital health technologies such as chatbot has accelerated. This study aimed to investigate the application of AI chatbots in combating COVID-19 pandemic and to explore their features.
Methods: We reviewed of literature on health chatbots during the COVID-19 pandemic. PubMed, Scopus, Web of Science and Google Scholar were searched by using related keywords such as "chatbot", “conversational agent” and “Artificial intelligence”. To select the relevant articles, we conducted title, abstract, and full-text screening based on inclusion/exclusion criteria. Chatbots, their applications and design features were extracted from selected articles.
Results: Out of 673 articles initially identified, 17 articles were eligible for inclusion. We categorized selected AI chatbots based on their roles, applications and design characteristics. 70% of chatbots had preventive role. Our review identified 8 key applications of the AI chatbots during the COVID-19 pandemic that includes: 1) information dissemination and education 2) self-assessment and screening 3) connect to health centers 4) combating misinformation and fake news 5) patients tracking and service delivery 6) mental health 7) monitoring exposure 8) vaccine information and scheduler. AI chatbots were deployed on various platforms including mobile apps, web and social media. Mobile-based chatbots were the most frequent. All of chatbots use NLU methods to understand natural language input and act on the user’s request. More than 50% of AI chatbots were used NLU platforms including Google Dialogflow, Rasa framework and IBM Watson.
Conclusion: The AI chatbots can play an effective role to combat COVID-19 pandemic. Increasing people's awareness, optimal use of health resources, reducing unnecessary encounters are some advantages of using AI chatbots during COVID-19 outbreak. Using NLU platforms can be a suitable solution in the development of AI chatbots in healthcare domain. With advancement of Artificial intelligence field, it seems that AI chatbots will mark a bright future in healthcare specially in public health, chronic diseases management and mental health.
Trimesic acid anchored electrocatalysts of bioinspired design: Unique static and dynamic compatibility enhanced water oxidation
Authors: Lin Xiaojing , Wang Zhaojie , Cao Shoufu , Hu Yuying , Liu Siyuan , Chen Xiaodong , Chen Hongyu , Zhang Xingheng , Wei Shuxian , Xu Hui , Cheng Zhi , Hou Qi , Sun Daofeng , Lu Xiaoqing 
Published: February 2023

Abstract
Layered double hydroxides (LDH) are successful candidates for electrocatalytic oxygen evolution reaction (OER). Unfortunately, their catalytic kinetics and long-term stability are far unsatisfactory comparing to rare metals in practice. Here we track the endurance of NiFe-LDH and uncover that the ablation of lamellar structure caused by metal dissolution is the immediate reason for the decreased stability. Inspired by amino acid residues in photosystem II, we report a strategy using trimesic acid anchor to achieve the subsize NiFe-LDH to drive with superior kinetics, activity and stability to the benchmark commercial catalysts. Fundamental investigations through operando spectroscopy and theoretical calculations reveal that the superaerophobic surface is beneficial for the immediate release of the generated O2 bubbles and maintaining its active structure as well. The coupling between metal and coordinated carboxylate by C‒O‒Fe bonds effectively prevent metal species from dissolving, which enhances the stabilization of electronic structure by the static coordination. In addition, the uncoordinated carboxylates formed by dynamic evolution on OER process act as proton ferries to accelerate the OER kinetics. This work offers a promising way to achieve breakthroughs in OER stability and dynamics performance by introducing functional ligand with static and dynamic compatibility.
Cribriform morphology area ratio and biochemical recurrence in Gleason score 4 + 4 prostate cancer patients following robot-assisted radical prostatectomy
Authors: Shimodaira Kenji , Inoue Rie , Hashimoto Takeshi , Satake Naoya , Shishido Toshihide , Namiki Kazunori , Nagao Toshitaka , Ohno Yoshio 
Published: February 2023

Abstract
Background Cribriform glands, regardless of their morphology and size, are categorized with Gleason pattern (GP) 4. However, recent studies indicate that the size and percentage of cribriform patterns in GP 4 are associated with risk of biochemical recurrence (BCR). Thus, we aimed to examine the prognostic value of the area and percentage of cribriform patterns in patients with Gleason score (GS) 4 + 4 prostate cancer who underwent robot-assisted radical prostatectomy (RARP).
Methods We investigated 108 patients with GS 4 + 4 prostate cancer who underwent RARP. After digitally scanning the slides, we measured the area of the entire cancer and cribriform patterns. Predictive factors for BCR were explored using the log-rank test and Cox proportional hazard model analyses.
Results Sixty-seven (62.0%) patients had a cribriform architecture in RARP specimens, and thirty-two (29.6%) experienced BCR. Median total cancer area (mm2), cribriform pattern area (mm2), and percentage of cribriform pattern area (% cribriform) were 427.70 (interquartile range [IQR], 171.65–688.53), 8.85 (IQR, 0–98.83), and 2.44 % (IQR, 0–33.70), respectively. In the univariate analyses, higher preoperative serum prostate-specific antigen levels, positive resection margin (RM), advanced pathological T stage, extraprostatic extension, larger total cancer area, larger cribriform morphology area, and higher % cribriform were significantly associated with BCR. Multivariate analysis demonstrated that PSA and % cribriform were independent predictors of BCR.
Conclusions Higher % cribriform was associated with BCR in GS 4 + 4 prostate cancer following RARP.