bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel quantitative software for automatically excluding red bone marrow on whole‐body magnetic resonance imaging in patients with metastatic prostate cancer: A pilot study
Authors: Kohada Yuki , Satani Nozomi , Kaiho Yasuhiro , Iwamura Hiromichi , Sakamoto Tsuyoshi , Kusumoto Hiroki , Kukimoto Takashi , Oikawa Masaaki , Mikami Jotaro , Ito Jun , Matsuura Tomonori , Hinata Nobuyuki , Koyama Kaneki , Sato Makoto 
Published: December 2022

ObjectivesTo establish a novel quantitative method that automatically excludes the red bone marrow and accurately quantifies the tumor volume on whole‐body magnetic resonance imaging using updated imaging software. To also evaluate the association between the quantified tumor volume and the prognosis of patients with metastatic prostate cancer.MethodsThis prospective analysis included patients diagnosed with metastatic hormone‐sensitive or metastatic castration‐resistant prostate cancer between 2017 and 2022. We developed an imaging software (Attractive BD_Score) that analyzed whole‐body diffusion‐weighted and in‐phase and opposed‐phase T1‐weighted images to automatically exclude the red bone marrow. The quantified tumor volume was compared with that quantified by traditional whole‐body diffusion‐weighted imaging without red bone marrow exclusion. Prostate‐specific antigen progression‐free survival, time‐to‐pain progression, and overall survival were evaluated to assess the prognostic value of the quantified tumor volume.ResultsThe quantified tumor volume was significantly smaller than that quantified by the traditional method in metastatic hormone‐sensitive (median: 81.0 ml vs. 149.4 ml) and metastatic castration‐resistant (median: 29.4 ml vs. 63.5 ml) prostate cancer. A highly quantified tumor volume was associated with prostate‐specific antigen progression‐free survival (p = 0.030), time‐to‐pain progression (p = 0.003), and overall survival (p = 0.005) in patients with metastatic hormone‐sensitive prostate cancer and with poor prostate‐specific antigen progression‐free survival (p = 0.001) and time‐to‐pain progression (p = 0.005) in patients with metastatic castration‐resistant prostate cancer.ConclusionsOur imaging method could accurately quantify the tumor volume in patients with metastatic prostate cancer. The quantified tumor volume can be clinically applied as a new prognostic biomarker for metastatic prostate cancer.
Changes in Erythrocyte Mg, Na and K Concentrations in Late Pregnancy and Early Lactation and their Relationship With Subsequent Fertility and Milk Production in Dairy Cows
Authors: Mulei C. M. , Daniel R. C. W. , Green D. 
Published: December 2022

SummaryWeekly blood samples were collected from 62 Friesian and Jersey cows between 8 weeks before and 8 weeks after calving and analysed for erythrocyte Mg (EMg), Na (ENa) and K (EK). No particular trend was observed for EMg concentration in both the pre‐partum and post‐partum periods. The concentrations of ENa decreased (P < 0.05) and that of EK increased (P<0.05) after calving. Significant (P<0.01) weekly and between cow variations were observed for both ENa and EK concentrations. The mean EMg concentration was correlated with milk production rank (r = 0.533, P <0.01) and services/conception (r = ‐0.458, P < 0.05) in the pre‐partum and post‐partum periods, respectively. The mean EK concentrations was correlated with milk production rank in both the pre‐partum (P<0.05) and post‐partum (P<0.01) periods. The relationship observed between EMg and EK concentrations and fertility/milk production rank implies that these parameters could be included in the metabolic profile testing parameters.
Naturally‐Occurring Neoplasms of the Preputial and Clitoral Gland in Han : SPRD Rats
Authors: Kaspareit‐Rittinghausen J. , Deerberg F. , Nitsche B. 
Published: December 2022

SummaryHistopathülogical findings of preputial and clitoral gland neoplasms found with high frequency (46 of 394 rats/11.7%) in the Han : SPRD outbred stock are reported. With one exception all the tumours were of squamous cell origin — papillomas (4), squamous cell carcinomas (41) and adenoacanthoma (1).
Effect of Long Distance Exercise on Free Fatty Acids in Blood Plasma of Arab Horses
Authors: Hambitzer R. , Bent Evelin 
Published: December 2022

SummaryFree fatty acids were determined in the blood plasma of Arab horses before and after long distance ride in order to evaluate lipid mobilization for energy supply. Palmitic acid, oleic acid and linoleic acid were the predominant fatty acid types (about 70 %) determined before and after the ride and accounted for most of the 7‐foid increase of free fatty acids after the ride. Free fatty acids did not increase linearly with the concentration of free glycerol in the plasma, probably due to different turnover rates. It was concluded from these results that the turnover rates of free fatty acids in blood plasma reflect an adaptation of Arab horses of long distance stress.
Women's power in hospital‐based nursing: A critical qualitative study
Authors: George Kaitlyn C. , Lyman Bret , Pilarte Alcantara Andy , Stephenson Maya 
Published: December 2022

AbstractAimTo understand the factors that affect power in hospital‐based nursing and reveal how the female gender affects an individual's ability to feel empowered.DesignCritical qualitative research design.MethodSemi‐structured interviews were conducted with nurses working in inpatient hospital settings in Utah and New Mexico. Data were collected from February to March 2022. Interviews were analysed using thematic analysis.ResultsSixteen participants were interviewed. Six themes were identified from the data, four of which related to nurses' power at work, and two of which specifically related to how gender affects a nurse's ability to use power and feel empowered. These themes include supportive leaders, positive unit culture, successful advocacy, personal factors, societal gender roles and sexism.ConclusionEmpowered nurses can revolutionize health care. The themes developed in this study will help nurse leaders and nurses alike increase nurses' ability to use their power and feel empowered in the workplace.ImpactNurse leaders should strive to be supportive of their nurses and build a positive work environment while also providing consistent consequences for sexist actions of staff. Nurses should take opportunities to advocate for their patients, be autonomous and build their knowledge base to improve empowerment. As nurse leaders and nurses alike work together to improve health care, nurse experience, patient and clinical outcomes will be improved.Patient or Public ContributionThe nurses interviewed for this study contributed their experiences and insights during data collection. Some also contributed rigour to the data analysis process by participating in member checking.
Accounting conservatism and common ownership by dedicated institutional blockholders
Authors: Cheng C. S. Agnes , Li Xiaohui (Fiona) , Xie Jing , Zhong Yuxiang 
Published: December 2022

AbstractWe examine the peer effects of accounting conservatism in a common dedicated institutional blockholder (CDIB) setting. We find a positive correlation in accounting conservatism between focal firms and their CDIB peers. To corroborate our main findings, we document that the peer effect is stronger for firms connected through CDIBs that are activists or that have more active shares, for firms with larger CDIB ownership and for firms with weaker corporate governance mechanisms and higher information asymmetry. The results suggest that managers view following peer firms’ conservatism as a way of pleasing CDIBs. We also find that in proxy voting, firms receive less support from their investors when their conservatism deviates more from their CDIB peers. Finally, we find that the CDIB peer effect remains significant after controlling for the effect of industry and local peers. Overall, our paper presents evidence consistent with firms adapting their accounting conservatism in response to their incumbent dedicated institutional investors’ preference.
Examining the role of micronutrients on improving long COVID sleep‐related symptoms
Authors: Pak Victoria M. , Lee Jiyun 
Published: December 2022

AbstractAims and ObjectivesLong COVID is defined as the continuation of symptoms for four or more weeks after initial contraction of the virus. This review article examines the role of four select micronutrients (zinc, vitamins C, D and polyphenols) for their anti‐inflammatory and therapeutic potential to improve sleep‐related symptoms in persons with long COVID.BackgroundEvidence suggests a link between long COVID and increased inflammation. There are currently no therapeutic interventions for common sleep‐related symptoms associated with long COVID. Micronutrients, due to their antioxidant and anti‐inflammatory properties, may have a role in the treatment of sleep‐related symptoms in the context of long COVID.DesignA narrative literature review was conducted and guided by the PRISMA checklist.MethodsAll articles were screened from PubMed, ScienceDirect, NCBI or Google Scholar and were limited to human studies. The following keywords were used: ‘COVID‐19’, ‘sleep symptoms’, ‘zinc’, ‘vitamin C’, ‘vitamin D’, ‘polyphenols’ and ‘micronutrients’.ResultsThere are currently no studies that examine the usage of micronutrients and its impacts on long‐term, sleep‐related symptoms post‐COVID‐19 infection. We focussed our review on prior studies that examined micronutrients in the context of sleep symptoms and inflammation, while exploring the potential for micronutrients to help improve sleep‐related symptoms associated with long COVID.ConclusionsThere is evidence to suggest that sleep‐related symptoms associated with long COVID, such as fatigue and poor sleep quality, are associated with inflammation. Zinc, vitamins C, D and polyphenols all have the potential to improve both inflammation and sleep quality to alleviate symptoms. Future research should further examine these micronutrients in the context of long COVID to improve sleep and quality of life.Relevance to Clinical PracticeThis article provides implications for clinicians to be at the forefront of research on the usage of micronutrients to improve sleep‐related symptoms in persons with long COVID.
Exploring the phycosphere of Emiliania huxleyi: From bloom dynamics to microbiome assembly experiments
Authors: Câmara dos Reis Mariana , Romac Sarah , Le Gall Florence , Marie Dominique , Frada Miguel J. , Koplovitz Gil , Cariou Thierry , Henry Nicolas , de Vargas Colomban , Jeanthon Christian 
Published: December 2022

AbstractCoccolithophores have global ecological and biogeochemical significance as the most important calcifying marine phytoplankton group. The structure and selection of prokaryotic communities associated with the most abundant coccolithophore and bloom‐forming species, Emiliania huxleyi, are still poorly known. In this study, we assessed the diversity of bacterial communities associated with an E. huxleyi bloom in the Celtic Sea (Eastern North Atlantic), exposed axenic E. huxleyi cultures to prokaryotic communities derived from bloom and non‐bloom conditions, and followed the dynamics of their microbiome composition over one year. Bloom‐associated prokaryotic communities were dominated by SAR11, Marine group II Euryarchaeota and Rhodobacterales and contained substantial proportions of known indicators of phytoplankton bloom demises such as Flavobacteriaceae and Pseudoalteromonadaceae. The taxonomic richness of bacteria derived from natural communities associated with axenic E. huxleyi rapidly shifted and then stabilized over time. The succession of microorganisms recruited from the environment was consistently dependent on the composition of the initial bacterioplankton community. Phycosphere‐associated communities derived from the E. huxleyi bloom were highly similar to one another, suggesting deterministic processes, whereas cultures from non‐bloom conditions show an effect of stochasticity. Overall, this work sheds new light on the importance of the initial inoculum composition in microbiome recruitment and elucidates the temporal dynamics of its composition and long‐term stability.
Epigenetic age acceleration is associated with oligodendrocyte proportions in MSA and control brain tissue
Authors: Murthy Megha , Shireby Gemma , Miki Yasuo , Viré Emmanuelle , Lashley Tammaryn , Warner Thomas T. , Mill Jonathan , Bettencourt Conceição 
Published: December 2022

AbstractAimsEpigenetic clocks are widely applied as surrogates for biological age in different tissues and/or diseases, including several neurodegenerative diseases. Despite white matter (WM) changes often being observed in neurodegenerative diseases, no study has investigated epigenetic ageing in white matter.MethodsWe analysed the performances of two DNA methylation‐based clocks, DNAmClockMulti and DNAmClockCortical, in post‐mortem WM tissue from multiple subcortical regions and the cerebellum, and in oligodendrocyte‐enriched nuclei. We also examined epigenetic ageing in control and multiple system atrophy (MSA) (WM and mixed WM and grey matter), as MSA is a neurodegenerative disease comprising pronounced WM changes and α‐synuclein aggregates in oligodendrocytes.ResultsEstimated DNA methylation (DNAm) ages showed strong correlations with chronological ages, even in WM (e.g., DNAmClockCortical, r = [0.80–0.97], p < 0.05). However, performances and DNAm age estimates differed between clocks and brain regions. DNAmClockMulti significantly underestimated ages in all cohorts except in the MSA prefrontal cortex mixed tissue, whereas DNAmClockCortical tended towards age overestimations. Pronounced age overestimations in the oligodendrocyte‐enriched cohorts (e.g., oligodendrocyte‐enriched nuclei, p = 6.1 × 10−5) suggested that this cell type ages faster. Indeed, significant positive correlations were observed between estimated oligodendrocyte proportions and DNAm age acceleration estimated by DNAmClockCortical (r > 0.31, p < 0.05), and similar trends were obtained with DNAmClockMulti. Although increased age acceleration was observed in MSA compared with controls, no significant differences were detected upon adjustment for possible confounders (e.g., cell‐type proportions).ConclusionsOur findings show that oligodendrocyte proportions positively influence epigenetic age acceleration across brain regions and highlight the need to further investigate this in ageing and neurodegeneration.
Neuronal and astrocytic tetraploidy is increased in drug‐resistant epilepsy
Authors: Sanz‐García Ancor , Sánchez‐Jiménez Patricia , Granero‐Cremades Inmaculada , de Toledo María , Pulido Paloma , Navas Marta , Frade José María , Pereboom‐Maicas Matilde Desirée , Torres‐Díaz Cristina Virginia , Ovejero‐Benito María C. 
Published: December 2022

AbstractAimsEpilepsy is one of the most prevalent neurological diseases. A third of patients with epilepsy remain drug‐resistant. The exact aetiology of drug‐resistant epilepsy (DRE) is still unknown. Neuronal tetraploidy has been associated with neuropathology. The aim of this study was to assess the presence of tetraploid neurons and astrocytes in DRE.MethodsFor that purpose, cortex, hippocampus and amygdala samples were obtained from patients subjected to surgical resection of the epileptogenic zone. Post‐mortem brain tissue of subjects without previous records of neurological, neurodegenerative or psychiatric diseases was used as control.ResultsThe percentage of tetraploid cells was measured by immunostaining of neurons (NeuN) or astrocytes (S100β) followed by flow cytometry analysis. The results were confirmed by image cytometry (ImageStream X Amnis System Cytometer) and with an alternative astrocyte biomarker (NDRG2). Statistical comparison was performed using univariate tests. A total of 22 patients and 10 controls were included. Tetraploid neurons and astrocytes were found both in healthy individuals and DRE patients in the three brain areas analysed: cortex, hippocampus and amygdala. DRE patients presented a higher number of tetraploid neurons (p = 0.020) and astrocytes (p = 0.002) in the hippocampus than controls. These results were validated by image cytometry.ConclusionsWe demonstrated the presence of both tetraploid neurons and astrocytes in healthy subjects as well as increased levels of both cell populations in DRE patients. Herein, we describe for the first time the presence of tetraploid astrocytes in healthy subjects. Furthermore, these results provide new insights into epilepsy, opening new avenues for future treatment.
The causal link between electricity transmission, distributional losses and economic growth in Ghana
Authors: Adabor Opoku , Ayesu Enock Kojo , Nana‐Amankwaah Elizabeth 
Published: December 2022

AbstractDespite the growing literature on the causal association between electricity supply and economic growth, little is known about the causal linkage between electricity transmission and distributional losses and economic growth, particularly in Ghana. The paper studies the causal association between electricity transmission, distributional losses and economic growth in Ghana. Further, we interacted ETDL with electricity price to examine their combined impact on Ghana's gross domestic product. We utilised time series data from the period 1971 to 2014. Given that our data span is relatively shorter, we utilised the Toda and Yamamoto and Autoregressive distributed lag model (ARDL) methods. This is so because these time series approaches can produce efficient, reliable and eliminate spurious regression estimates even if the sample size is relatively short. Our ARDL estimates suggest that ETDL exert an adverse impact on economic growth while the Toda and Yamamoto estimates suggest that economic growth has a strong influence on ETDL and not the other way round, supporting the growth‐led energy hypothesis. Also, the interactive effect of ETDL and electricity prices on economic growth was negative and statistically significant.
Asymmetric relationship between oil prices and remittances in oil‐importing and ‐exporting countries: Evidence from sub‐Saharan Africa
Authors: Dada James Temitope , Akinlo Taiwo 
Published: December 2022

AbstractThis study investigated the asymmetric impact of oil price on remittances in oil‐exporting and ‐importing nations in sub‐Saharan Africa (SSA). The study adopted the nonlinear autoregressive distributed lag (NARDL) technique for 22 SSA countries. The study found that in oil‐importing countries, positive shocks in oil prices boost the influx of remittances, whereas a fall in oil prices reduces remittances. For oil‐exporting nations, the result indicates that the influence of a positive shock in oil price on remittances, in the long‐run, is sensitive to the measure of oil price (Brent and West Texas Intermediate). However, in the short‐run, adverse oil price shocks decrease the inflow of oil‐importing nations' remittances while it enhances the inflow of remittances into oil‐exporting nations. Based on these findings, the study recommends that oil‐importing nations use the increase in remittances to promote economic activities to lessen the adverse effect of an upsurge in international oil prices. By contrast, oil‐exporting nations need to use the rise in oil revenue to cushion the decrease in remittances due to oil price shock.
The Portuguese version of the musculoskeletal pain intensity and interference questionnaire for musicians (MPIIQM‐Pt): Translation, cultural adaptation, and multicenter validation study in professional orchestra musicians
Authors: Zão Ana , Coimbra Daniela , Aguiar‐Branco Catarina , Altenmüller Eckart , Azevedo Luís 
Published: December 2022

AbstractObjectivesWe aim to assess the validity and reliability of the Musculoskeletal Pain Intensity and Interference Questionnaire for Musicians (MPIIQM) and to add to its cross‐cultural adaptation process by translating, culturally adapting, and validating the MPIIQM into European Portuguese language in the population of Portuguese musicians.MethodsA Portuguese version of the MPIIQM (MPIIQM‐Pt) was created through a process of forward and back translation, pilot testing, and cultural adaptation by expert panel evaluation. The psychometric evaluation was performed in a validation sample of 134 musicians, at baseline and after 7 days.ResultsThe high degree of internal consistency and the substantial test–retest reliability coefficients were demonstrated for each subscale (α = 0.896 and ICC = 0.997 for “pain intensity,” and α = 0.879 and ICC = 0.999 for “pain interference,” respectively). Exploratory factor analysis indicated two‐factor structure (pain intensity and interference) that explained 75.5% of the variance. Both convergent and divergent validity are well demonstrated, confirming more than 90% of the previously defined hypotheses regarding correlations with other measures.DiscussionMPIIQM‐Pt is the first validated questionnaire to evaluate pain among Portuguese musicians. It showed excellent psychometric properties, both in terms of internal consistency, test–retest reliability, factor analysis, and construct validity. Therefore, it is a valid and reliable tool suitable for both research and clinical practice purposes. MPIIQM‐Pt will allow the development of more robust studies on pain among musicians and the improved assessment and monitoring of pain in this population, filling an important gap in this field of Pain Medicine.
A bibliometric analysis of self‐efficacy in low back pain from 1980 to 2021
Authors: Wang Zhe , Simon Klára , Makai Alexandra , Jaromi Melinda 
Published: December 2022

AbstractBackgroundSelf‐efficacy is one of the important factors affecting chronic diseases. In the current epidemiological context of low back pain (LBP), LBP self‐efficacy has become a topic of great practical interest for researchers. However, no bibliometric analysis related to LBP self‐efficacy has been performed to date. The purpose of this study was to conduct and explore the current state of research in LBP self‐efficacy from 1980 to 2021, by using bibliometric analysis and scientific mapping.MethodsRaw data were selected from the Web of Science (WOS) database, relevant literature on LBP self‐efficacy was retrieved, and data were de‐duplicated and cleaned. Excel was used for data processing. CiteSpace 5.8.R3 was used for bibliometric analysis and scientific mapping in publications and country, institution, journals, authors, references, and keywords. Statistical analysis was performed using IBM SPSS 25.0.ResultsThere were 822 references included. For this period, the total publication numbers were increased. A total of 103 regions had researchers in this area; the United States was the country with the largest volume of research. There were 94 disciplines, mainly in neuroscience. More research is likely to burst and develop quickly in general and internal medicine in the future. Spine was the most recognized journal. Cognitive‐behavioral manifestations and older adults with LBP might be the frontiers and trends.ConclusionThe volume of literature on LBP self‐efficacy has increased linearly over the past 41 years and will continue to increase. The field of study has become more refined. This bibliometric analysis provides valuable support for future directions and research trends in LBP self‐efficacy.