bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining technology-assisted rehabilitation for older adults’ functional mobility: a network meta-analysis on efficacy and acceptability
Authors: Cieślik Błażej , Mazurek Justyna , Wrzeciono Adam , Maistrello Lorenza , Szczepańska-Gieracha Joanna , Conte Pierfranco , Kiper Pawel 
Published: August 2023

AbstractTechnological advancements facilitate feedback adaptation in rehabilitation through virtual reality (VR) exergaming, serious gaming, wearables, and telerehabilitation for older adults fall prevention. Although studies have evaluated these technologies, no comparisons of their effectiveness have been conducted to date. Thus, this study aims to assess the differences in effectiveness of these interventions on balance and functional mobility in the older adults. A systematic review and network meta-analysis (NMA) were conducted to identify the most effective interventions for improving balance and functional mobility in adults aged 60 and over. The search was conducted in five databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science) up to June 10, 2023. The eligibility criteria were: (1) older adults, (2) functional mobility, balance, or gait as the primary outcome, (3) new technology intervention, and (4) randomized study design. New technology interventions were classified into five categories: exergaming with balance platforms or motion capture technologies, other serious gaming, interventions with wearables, and telerehabilitation. Additionally, two categories of control interventions (conventional exercises and no treatment) were extracted. The NMA was performed for the aggregated results of all outcomes, and separately for clinical functional scales, functional mobility, and gait speed results. Fifty-two RCTs with 3081 participants were included. Exergaming with motion capture was found to be statistically significant in producing a better effect than no treatment in the analysis of the functional mobility with an SMD of −0.70 (P < 0.01). The network meta-analysis revealed that exergaming with motion capture offers greater therapeutic benefits for functional mobility and balance compared to no treatment control. The effectiveness of this approach is similar to that of conventional exercises. Further RCTs are needed to provide a more definitive conclusion, particularly with respect to the effectiveness of serious games, telerehabilitation, and interventions with wearables.
Dynamic expectations: Behavioral and electrophysiological evidence of sub-second updates in reward predictions
Authors: Marciano Déborah , Bellier Ludovic , Mayer Ida , Ruvalcaba Michael , Lee Sangil , Hsu Ming , Knight Robert T. 
Published: August 2023

AbstractExpectations are often dynamic: sports fans know that expectations are rapidly updated as games unfold. Yet expectations have traditionally been studied as static. Here we present behavioral and electrophysiological evidence of sub-second changes in expectations using slot machines as a case study. In Study 1, we demonstrate that EEG signal before the slot machine stops varies based on proximity to winning. Study 2 introduces a behavioral paradigm to measure dynamic expectations via betting, and shows that expectation trajectories vary as a function of winning proximity. Notably, these expectation trajectories parallel Study 1’s EEG activity. Studies 3 (EEG) and 4 (behavioral) replicate these findings in the loss domain. These four studies provide compelling evidence that dynamic sub-second updates in expectations can be behaviorally and electrophysiologically measured. Our research opens promising avenues for understanding the dynamic nature of reward expectations and their impact on cognitive processes.
Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots
Authors: Michael Christian , Pancaldi Francesco , Britton Samuel , Kim Oleg V. , Peshkova Alina D. , Vo Khoi , Xu Zhiliang , Litvinov Rustem I. , Weisel John W. , Alber Mark 
Published: August 2023

AbstractWhile blood clot formation has been relatively well studied, little is known about the mechanisms underlying the subsequent structural and mechanical clot remodeling called contraction or retraction. Impairment of the clot contraction process is associated with both life-threatening bleeding and thrombotic conditions, such as ischemic stroke, venous thromboembolism, and others. Recently, blood clot contraction was observed to be hindered in patients with COVID-19. A three-dimensional multiscale computational model is developed and used to quantify biomechanical mechanisms of the kinetics of clot contraction driven by platelet-fibrin pulling interactions. These results provide important biological insights into contraction of platelet filopodia, the mechanically active thin protrusions of the plasma membrane, described previously as performing mostly a sensory function. The biomechanical mechanisms and modeling approach described can potentially apply to studying other systems in which cells are embedded in a filamentous network and exert forces on the extracellular matrix modulated by the substrate stiffness.
Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework
Authors: Zhao Haochen , Ni Peng , Zhao Qichang , Liang Xiao , Ai Di , Erhardt Shannon , Wang Jun , Li Yaohang , Wang Jianxin 
Published: August 2023

AbstractAdverse Drug Reactions (ADRs) have a direct impact on human health. As continuous pharmacovigilance and drug monitoring prove to be costly and time-consuming, computational methods have emerged as promising alternatives. However, most existing computational methods primarily focus on predicting whether or not the drug is associated with an adverse reaction and do not consider the core issue of drug benefit-risk assessment—whether the treatment outcome is serious when adverse drug reactions occur. To this end, we categorize serious clinical outcomes caused by adverse reactions to drugs into seven distinct classes and present a deep learning framework, so-called GCAP, for predicting the seriousness of clinical outcomes of adverse reactions to drugs. GCAP has two tasks: one is to predict whether adverse reactions to drugs cause serious clinical outcomes, and the other is to infer the corresponding classes of serious clinical outcomes. Experimental results demonstrate that our method is a powerful and robust framework with high extendibility. GCAP can serve as a useful tool to successfully address the challenge of predicting the seriousness of clinical outcomes stemming from adverse reactions to drugs.
Simulations of dynamo action in slowly rotating M dwarfs: Dependence on dimensionless parameters
Authors: Ortiz-Rodríguez C. A. , Käpylä P. J. , Navarrete F. H. , Schleicher D. R. G. , Mennickent R. E. , Hidalgo J. P. , Toro-Velásquez B. 
Published: August 2023

Aims. The aim of this study is to explore the magnetic and flow properties of fully convective M dwarfs as a function of rotation period Prot and magnetic Reynolds ReM and Prandlt numbers PrM.
Methods. We performed three-dimensional simulations of fully convective stars using a star-in-a-box set-up. This set-up allows global dynamo simulations in a sphere embedded in a Cartesian cube. The equations of non-ideal magnetohydrodynamics were solved with the PENCIL CODE. We used the stellar parameters of an M5 dwarf with 0.21 M⊙ at three rotation rates corresponding to rotation periods (Prot) of 43, 61, and 90 days, and varied the magnetic Prandtl number in the range from 0.1 to 10.
Results. We found systematic differences in the behaviour of the large-scale magnetic field as functions of rotation and PrM. For the simulations with Prot = 43 days and PrM ≤ 2, we found cyclic large-scale magnetic fields. For PrM > 2, the cycles vanish and the field shows irregular reversals. In the simulations with Prot = 61 days for PrM ≤ 2, the cycles are less clear and the reversal are less periodic. In the higher PrM cases, the axisymmetric mean field shows irregular variations. For the slowest rotation case with Prot = 90 days, the field has an important dipolar component for PrM ≤ 5. For the highest PrM the large-scale magnetic field is predominantly irregular at mid-latitudes, with quasi-stationary fields near the poles. For the simulations with cycles, the cycle period length slightly increases with increasing ReM.
Investigating the outskirts of Abell 133 with Suzaku and Chandra observations
Authors: Zhu Zhenlin , Kovács Orsolya E. , Simionescu Aurora , Werner Norbert 
Published: August 2023

Context. Past observations and simulations have predicted an increasingly inhomogeneous gas distribution towards the outskirts of galaxy clusters. However, the exact properties of such gas clumping are not yet well known. The outskirts of Abell 133 can benefit from deep X-ray observations, with a 2.4 Ms ultra-deep Chandra exposure, as well as eight archival Suzaku pointings, making it a unique laboratory for studying the clumping of the intracluster medium (ICM).
Aims. We searched for significant clump candidates with the specific aim of identifying ones that could represent genuine ICM inhomogeneity. To further understand how clumping biases the thermodynamic profiles, we compared the measurements including and excluding the clump candidates.
Methods. We jointly analyzed Chandra and Suzaku observations of Abell 133. We selected clump candidates with at least 2σ significance based on the Chandra image and we discussed their origins further, using information from the DESI Legacy Imaging Surveys cluster catalog as well as the CFHT r-band image. We performed multiple rounds of Suzaku spectral analysis with different corrections for the underlying point sources and clump distribution and we compared the resulting thermodynamic profiles.
Results. We detected 16 clump candidates using Chandra, most of which are identified as background clusters or galaxies – as opposed to intrinsic inhomogeneity. Even after the correction of the resolved clumps, the entropy profile approaching the outskirts still flattens, deviating from the power law model expected from self-similar evolution, which implies that unresolved clumping and other complex physics contribute to the entropy flattening in the outskirts.
Arterial-Venous Perfusion Without Anticoagulation to Reverse Accidental Hypothermia
Authors: Vertrees Roger , Fuller Sidney , Hundley D.Scott , Costabile Joseph , Yu Yan , Cilley Jonathan H. , Baldino William A. , DelRossi Anthony J. 
Published: August 2023

To investigate a means of rewarming individuals suffering from accidental hypothermia, five Yucatan swine were topically cooled to a core body temperature of 30#x00B0;C. No heparin or any other means of anticoagulation was administered. An extracorporeal circuit consisting of polyvinylchloride tubing, a Bio-Pump and an external stainless steel heat exchanger was utilized and primed with an albuminized Ringers solution. An arterial-venous circuit was employed with oxygenation being provided by the animals' lungs. A series of aliquots of blood were taken and analyzed for coagulation prior to cannulation, after stabilization of blood flows, at a rectal rewarming temperature of 32°C and post-decannulation.
All subjects were effectively rewarmed to 34°C, with a mean perfusion time of 64.8 ± 8.5 minutes. Coagulation parameters showed very little alteration from the control values taken: PT (11.9 ± .5), PTT (16.0 ± .9), platelet count (456.0 ± 105.6) and normal fibrinogen levels. Necropsy examination revealed only minimal clot formation within either the extracorporeal circuit or the animals' vascular system.
Our results support the hypothesis that circulatory assistance and ultimately, extracorporeal circulation may be possible without anticoagulation.
Venovenous Long Term Extracorporeal CO2 Removal With Biopump and Hollow Fiber Membrane Oxygenator For the Failing Lung
Authors: Everts Peter , Franssen Theo , Schipper Rob , Meinsma Kees , Boon Willem , Berreklouw Eric , Steenbrink John , Bavinck Hans 
Published: August 2023

A 14-year-old male patient developed a severe respiratory insufficiency after a cart racing accident complicated by a bilateral pneumothorax, lung contusion and a rupture of a segmental lobe bronchus, for which two subsequential surgical interventions were needed.
Due to a decreased lung compliance, alveolar ventilation was decreased to a minimum, resulting in the development of hypercapnia.
The patient was placed on partial venovenous bypass utilizing the Biomedicus centrifugal pump and two Sarns hollow fiber membrane oxygenators, in combination with low frequency positive pressure ventilation, for extracorporeal CO2 removal with limited anticoagulation.
This case report illustrates the safe use and continuous effective performance of the hollow fiber membrane oxygenator and centrifugal pump for more than 60 hours.
Despite all efforts to create an environment for the lungs to heal, the patient succumbed due to irreversible traumatic cerebral damage and the bypass procedure was terminated after 60 hours.
Cardiopulmonary Bypass Without Systemic Heparinization for 24 Hours
Authors: von Segesser Ludwig , Turina Marko 
Published: August 2023

Cardiopulmonary bypass without systemic heparinization was realised by means of heparin surface COATED oxygenators and tubing sets and analysed in comparison to UNCOATED oxygenators and tubing sets with systemic heparinization (ACT>400s). Seven dogs were perfused for up to 24 hours (when perfusion was electively terminated) with a pumpflow of 50 ml/min/kg bodyweight and either heparin surface COATED equipment (34±5 kg) or UNCOATED equipment (40±7 kg) by cavo-aortic cannulation after median sternotomy. Besides continuous monitoring of hemodynamics, blood samples for blood gas, biochemical and hematological analyses were taken before, FIVE minutes after beginning of cardiopulmonary bypass and at regular intervals thereafter (see chart on page 82).
Mean duration of perfusion was 23±2 hours for COATED versus 20±5 hours for UNCOATED. Adequate gas exchange was obtained with COATED and UNCOATED equipment throughout the perfusion. Plasma hemoglobin production was significantly lower with COATED equipment which allowed open-chest cardiopulmonary bypass without return of shed blood for 13±1 hours.
Fellowship award in cardiovascular perfusion: Perfusion Techniques of Profound Hypothermia and Circulatory Arrest for Pulmonary Thromboendarterectomy
Authors: Winkler Mary H. , Rohrer Charlene H. , Ratty Susan C. , Jamieson Stuart , Dembitsky Walter , Moser Kenneth , Auger William 
Published: August 2023

One hundred ninety-five patients with the diagnosis of chronic pulmonary thromboembolic pulmonary hypertension have been operated on utilizing a standardized protocol involving profound hypothermia and circulatory arrest. A small subgroup, nine, were identified preoperatively as having heparin-associated thrombocytopenia (HAT). This challenging subgroup of patients was treated during heparin exposure with an investigational, “platelet disaggregating” agent, Iloprost.
The surgical procedure of pulmonary thromboendarterectomy requires multiple periods of circulatory arrest under profound hypothermia. Perfusion management of this procedure involves cerebral and myocardial protection, cooling, reperfusion at hypothermia and rewarming, treatment with Iloprost when appropriate, and methods of hemodilution.
Lumbale Spinalkanalstenose – Update zur minimalinvasiven Chirurgie
Authors: Lange Nicole , Ryang Yu-Mi , Scheer Maximilian , Meyer Bernhard 
Published: August 2023

ZusammenfassungIn der modernen Neurochirurgie stehen vermehrt minimalinvasive Operationstechniken zur
Verfügung. Hier sollen am Beispiel der lumbalen Spinalkanalstenose einige dieser Techniken
erklärt und bewertet werden. Diese sind die indirekte Dekompression via XLIF und ALIF-Zugang,
der minimalinvasive TLIF, roboterassistierte Schraubenanlage, sowie
Single-Position-Surgery.
Basis for fulfilling responsibilities, behavior, and professionalism of government agencies and effectiveness in public–public collaboration for food safety risk management
Authors: Wu Linhai , Zhang Liwei , Li Yufeng 
Published: August 2023

AbstractFood safety risk management is an important cross-boundary issue around the world from both theoretical and practical perspectives. Public–public collaboration is the most basic form of cross-boundary governance. This study investigates the main factors affecting the governance effectiveness in public–public collaboration for food safety risk management through a questionnaire survey in Jiangsu Province and Guangxi Zhuang Autonomous Region, China, using a multivariable linear regression model based on principal component analysis. The results show that although the governance effectiveness in public–public collaboration is affected by many factors, the most important of which are the behavior and capabilities of legislative, administrative regulation and enforcement, and environmental improvement government (public) agencies, professionalism of government agencies, and laws and regulations as the basis for government agencies to perform their responsibilities. This research provides a case study for the academic community to better understand the main problems facing public–public collaboration for food safety risk management in China. It also provides insights into promoting public–public collaboration in developing countries.
Aspects de l’évolution des relations cataphoriques
Authors: Combettes Bernard 
Published: August 2023

Résumé
En prenant comme champ d’observation la période de transition qui mène du français classique au français moderne, cette étude essaye de montrer comment l’évolution des relations cataphoriques est en relation avec les changements qui ont conduit à la « phrase complexe » du français moderne et contemporain. Adoptant une définition large de la cataphore, on prend en considération non seulement les constructions qui présentent des formes anaphoriques, mais également les constructions qui contiennent des anaphores sous-jacentes, avec, en particulier, le cas des prédications secondes. Sont examinées les modifications qui concernent les degrés de la connaissance partagée, en montrant comment la relation cataphorique s’exerce de plus en plus fréquemment sur des référents à faible degré de saillance, qui doivent être réactivés.
Influence of tube and patient positioning in thoracoabdominal CT examinations on radiation exposure–towards a better patient positioning
Authors: Valentin Birte , Kamp Benedikt , Henke Jan , Ljimani Alexandra , Appel Elisabeth , Antoch Gerald , Steuwe Andrea 
Published: August 2023

Abstract
Although iso-centric patient positioning is enormously important in computed tomography (CT), it is complicated in thoracoabdominal imaging by the varying dimensions of the body. Patient positioning can affect the appearance of the patient on the localiser. Positioned too close to the x-ray tube, a patient appears considerably more voluminous. The goal of this study is to assess the difference in radiation exposure of combined chest and abdomen CT scans between scans with prior 0°- and 180°-localisers in conjunction with patient positioning. In this IRB-approved retrospective study, patients who had two routine thoracoabdominal CT scans on the same CT scanner, one with a prior 0°- and one with a prior 180°-localiser, were included. To evaluate the radiation exposure of the thoracoabdominal CT examination regarding the tube position during the localiser, volumetric computed tomography dose index (CTDIvol), size-specific dose estimate (SSDE), patient diameter and positioning within the iso-centre for three positions (heart, abdomen, femur level) were compared with regard to the tube position during the prior localiser. CT examinations of 114 patients were included. Despite similar patient weight and diameter between the two examinations, SSDE and CTDIvol was significantly larger (up to 73%) with 180°-localisers. Patient offset from the iso-centre ranged between −9 mm at the centre slice (abdomen level) to −43 mm at the most caudal slice at the pelvis (femur level), causing a significant magnification (p < 0.001) on 180°-localisers with a subsequent increase of the apparent attenuation. The results of this study emphasise the use of 0°-localisers in thoracoabdominal CTs, since 180°-localisers caused patient magnification with subsequent increase in radiation exposure. The advantage of 180°-localisers, namely reducing the dose in thyroid and breast, is eliminated if the dose of the CT scan increases significantly in the abdomen and pelvis.
Remaining useful life prediction for rolling bearings based on RVM-Hausdorff distance
Authors: Xu Peihua , Tu Zhaoyu , Li Menghui , Wang Jun , Wang Xian-Bo 
Published: August 2023

Abstract
To address the shortcomings of existing bearing remaining useful life (RUL) prediction process such as low accuracy and reliance on expert experience for parameter estimation, this paper proposes a bearing RUL prediction method combining relevance vector (RV) machine (RVM) and hybrid degradation model. The bearing degradation characteristics are extracted from the acquired vibration acceleration signals, the time-varying 3σ criterion is then used to determine the bearing first predicting time, and the sequence from initial failure time point to the inspection time is regressed by differential kernel parameter RVM to obtain the different sparse RVs. A mixed degenerate model combined single exponential, weighted double exponential, and polynomial is used to fit the sparse RVs to obtain the fitted curve clusters. The similarity based on bidirectional Hausdorff distance is used to select the best degradation curve, and to extrapolate the best degradation curve to the failure threshold. The experimental results indicate that the proposed method overcomes the widespread drawbacks of monotonicity and trend bias in model-based methods, and has better prediction efficiency than the conventional exponential models.
Sustainable approach for adsorptive removal of cationic and anionic dyes by titanium oxide nanoparticles synthesized biogenically using algal extract of Spirulina
Authors: Sharma Anuj , Mittal Rishi , Sharma Praveen , Pal Kaushik , Mona Sharma 
Published: August 2023

Abstract
Worldwide, dyes are significant pollutants present in water because of their huge consumption for industrial purposes. These dyes as pollutants cause serious health issues in human beings and cause the loss of aquatic biodiversity. So, remediation of pollutants like dyes from wastewater is the need of the hour. In the present study, we greenly synthesized Spirulina-mediated titanium oxide nanoparticles (STONPs) for the adsorptive remediation of methyl orange (MO) (anionic) and malachite green (MG) (cationic) dyes. The characterization of STONPs was performed by Field emission scanning electron microscopy (FESEM) with EDX, FT-IR, XRD, Zeta Potential and particle size analyzer, Raman spectroscopy, and UV–vis. The various parameter effects like pH, nano-adsorbent dose, the concentration of dye, contact time, and temperature were also examined. Adsorption isotherms like Langmuir, Freundlich, and Temkin, and Kinetics models like Elovich Model, Pseudo 1st, intraparticle diffusion model (IPDM), Pseudo 2nd order, and the thermodynamic model were applied for a stronger interpretation. The q
max attained utilizing the Langmuir adsorption model was 272.4795 mg g−1 and 209.6436 mg g−1 for MO and MG correspondingly. The regeneration study of synthesized nanomaterials up to five cycles was also done. We found that greenly synthesized STONPs have great potential for adsorptive remediation for both MG and MO dyes.