bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blackfoot Words: a database of Blackfoot lexical forms
Authors: Weber Natalie , Brown Tyler , Celli Joshua , Denham McKenzie , Dykstra Hailey , Hernandez-Merlin Rodrigo , Hochstein Evan , Hwang Pinyu , Kidd Nico , Kulmizev Diana , Morrison Hannah , Norris Matty , Venkatraman Lena 
Published: April 2023

AbstractThis paper describes the structure and creation of Blackfoot Words, a new relational database of lexical forms (inflected words, stems, and morphemes) in Blackfoot (Algonquian; ISO 639-3: bla). To date, we have digitized 63,493 individual lexical forms from 30 sources, representing all four major dialects, and spanning the years 1743–2017. Version 1.1 of the database includes lexical forms from nine of these sources. This project has two aims. The first is to digitize and provide access to the lexical data in these sources, many of which are difficult to access and discover. The second is to organize the data so that connections can be made between instances of the “same” lexical form across all sources, despite variation across sources in the dialect recorded, orthographic conventions, and the depth of morpheme analysis. The database structure was developed in response to these aims. The database comprises five tables: Sources, Words, Stems, Morphemes, and Lemmas. The Sources table contains bibliographic information and commentary on the sources. The Words table contains inflected words in the source orthography. Each word is broken down into stems and morphemes which are entered into the Stems and Morphemes tables in the source orthography. The Lemmas table contains abstract versions of each stem or morpheme in a standardized orthography. Instances of the same stem or morpheme are linked to a common lemma. We expect that the database will support projects by the language community and other researchers.
From local knowledge to decision making in climate change adaptation at basin scale. Application to the Jucar River Basin, Spain
Authors: Marcos-Garcia P. , Pulido-Velazquez M. , Sanchis-Ibor C. , García-Mollá M. , Ortega-Reig M. , Garcia-Prats A. , Girard C. 
Published: April 2023

Abstract
Climate change is challenging the conventional approaches for water systems planning. Two main approaches are commonly implemented in the design of climate change adaptation plans: impact-oriented top-down approaches and vulnerability-oriented bottom-up approaches. In order to overcome the shortcomings of both approaches and take advantage of their strengths, we propose an integrative methodology to define adaptation strategies at basin scale, identifying and combining potential changes in water demand and water supply infrastructure along with climate variability and change. The impact of climate change on future local water availability is assessed applying a top-down approach. Local knowledge is used through a participatory bottom-up approach to foresee future scenarios of evolution of the agricultural sector and agricultural water demand, and to identify locally relevant adaptation strategies. A hydroeconomic model integrates the information from both approaches to identify a socially acceptable and cost-effective program of measures for each climate scenario. This method was applied to the Jucar basin, a highly regulated basin with a tight equilibrium between water resources and demands. The results show an important variability of climate change impacts across the basin, with main inflow reductions in the headwaters. The stakeholders prioritized the adaptation options of change to drip irrigation, use of non-conventional resources, and changes in water governance. The results obtained from the hydroeconomic model show that the portfolio of selected adaptation measures could significantly reduce the system’s average annual deficit and cost.
GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation
Authors: Hassan Ghmkin , Afify Said M. , Zahra Maram H. , Nawara Hend M. , Kumon Kazuki , Iwasaki Yoshiaki , Salomon David S. , Seno Akimasa , Seno Masaharu 
Published: April 2023

AbstractInduced pluripotent stem cells (iPSCs) are useful tools for modeling diseases and developing personalized medicine. We have been developing cancer stem cells (CSCs) from iPSCs with conditioned medium (CM) of cancer-derived cells as the mimicry of the microenvironment of tumor initiation. However, the conversion of human iPSCs has not always been efficient with only CM. In this study, human iPSCs reprogrammed from monocytes of healthy volunteers were cultured in a media containing 50% of the CM from human pancreatic cancer derived BxPC3 cells supplemented with a MEK inhibitor (AZD6244) and a GSK-3α/β inhibitor (CHIR99021). The survived cells were assessed for the characteristics of CSCs in vitro and in vivo. As a result, they exhibited CSC phenotypes of self-renewal, differentiation, and malignant tumorigenicity. Primary culture of the malignant tumors of the converted cells exhibited the elevated expression of CSC related genes CD44, CD24 and EPCAM maintaining the expression of stemness genes. In conclusion, the inhibition of GSK-3α/β and MEK and the microenvironment of tumor initiation mimicked by the CM can convert human normal stem cells into CSCs. This study could provide insights into establishing potentially novel personalized cancer models which could help investigate the tumor initiation and screening of personalized therapies on CSCs.
Using attention-based neural networks for predicting student learning outcomes in service-learning
Authors: Fu Eugene Yujun , Ngai Grace , Leong Hong Va , Chan Stephen C.F. , Shek Daniel T.L. 
Published: April 2023

AbstractAs a high-impact educational practice, service-learning has demonstrated success in positively influencing students’ overall development, and much work has been done on investigating student learning outcomes from service-learning. A particular direction is to model students’ learning outcomes in the context of their learning experience, i.e., the various student, course, and pedagogical elements. It contributes to a better understanding of the learning process, a more accurate prediction of students’ attainments on the learning outcomes, and improvements in the design of learning activities to maximize student learning. However, most of the existing work in this area relies on statistical analysis that makes assumptions about attribute independence or simple linear dependence, which may not accurately reflect real-life scenarios. In contrast, the study described in this paper adopted a neural network-based approach to investigate the impact of students’ learning experience on different service-learning outcomes. A neural network with attention mechanisms was constructed to predict students’ service-learning outcomes by modeling the contextual information from their various learning experiences. In-depth evaluation experiments on a large-scale dataset collected from more than 10,000 students showed that this proposed model achieved better accuracy on predicting service-learning outcomes. More importantly, it could capture the interdependence between different aspects of student learning experience and the learning outcomes. We believe that this framework can be extended to student modeling for other types of learning activities.
Intercultural communicative competence in higher education through telecollaboration: typology and development
Authors: Gutiérrez-Santiuste Elba , Ritacco-Real Maximiliano 
Published: April 2023

AbstractThis study aims to analyse intercultural communicative competence, understood as the individual’s ability to effectively and appropriately develop communication and behaviour, when interacting in an intercultural context. In this study, the Behavioural, Affective and Cognitive Dimensions, and their sub–dimensions, are considered by using videoconferencing as a tool for telecollaboration in Higher Education. These sub–dimensions are observed according to their positive and negative orientation (facilitating or inhibiting). The objectives of the current study are to analyse the dimensions and sub–dimensions distribution, to assess the incidence of the typology of generic and specific topics, and to assess the over time communication evolution. Content analysis of communications between university peers was carried out and we undertook a percentage frequency index. The results show behavioural communications to be in the majority, followed by affective and, finally, cognitive communications. Communications with a negative aspect are almost absent from this study. MANOVA was performed to investigate differences between typologies of topics (generic/specific) in dimensions. This research founds statistically significant differences in Affective Dimension. ANOVAs were conducted to observe if there are differences in the development over time of Behavioural, Affective and Cognitive Dimensions of intercultural online communications. There was a significant effect over time in Affective and Behavioural Dimension. The present study finds expressions that show a positive attitude towards communication, as well as interest in and an effort to maintain it. We can conclude that, in Affective Dimension, where generic topics enhance communication, while educational topics inhibit it. However, a sustained evolution over time has not been found, rather a significant incidence depending on topic themes.
All-cause mortality among Danish nursing home residents before and during the COVID-19 pandemic: a nationwide cohort study
Authors: Andersen Mikkel Porsborg , Mills Elisabeth Helen Anna , Meddis Alessandra , Sørensen Kathrine Kold , Butt Jawad Haider , Køber Lars , Poulsen Henrik Enghusen , Phelps Matthew , Gislason Gunnar , Christensen Helle Collatz , Schou Morten , Fosbøl Emil L. , Gerds Thomas Alexander , Kragholm Kristian , Torp-Pedersen Christian 
Published: April 2023

AbstractA substantial part of mortality during the COVID-19-pandemic occurred among nursing home residents which caused alarm in many countries. We investigate nursing home mortality in relation to the expected mortality prior to the pandemic. This nationwide register-based study included all 135,501 Danish nursing home residents between 2015 until October 6, 2021. All-cause mortality rates were calculated using a standardization method on sex and age distribution of 2020. Survival probability and lifetime lost for 180 days was calculated using Kaplan Meier estimates. Of 3,587 COVID-19 related deaths, 1137 (32%) occurred among nursing home residents. The yearly all-cause mortality rates per 100,000 person-years in 2015, 2016, and 2017 were 35,301 (95% CI: 34,671–35,943), 34,801 (95% CI: 34,180–35,432), and 35,708 (95% CI: 35,085–36,343), respectively. Slightly elevated mortality rates per 100,000 person-years were seen in 2018, 2019, 2020, and 2021 of 38,268 (95% CI: 37,620–38,929), 36,956 (95% CI: 36,323–37,600), 37,475 (95% CI: 36,838–38,122), and 38,536 (95% CI: 37,798–39,287), respectively. For SARS-CoV-2-infected nursing home residents, lifetime lost difference was 42 days (95% CI: 38–46) in 2020 versus non-infected in 2018. Among vaccinated in 2021, lifetime lost difference was 25 days (95% CI: 18–32) for SARS-CoV-2-infected versus non-infected. Even though a high proportion of COVID-19 fatalities took place in nursing homes and SARS-CoV-2-infection increased the risk of individual death, the annual mortality was only slightly elevated. For future epidemics or pandemics reporting numbers of fatal cases in relation to expected mortality is critical.
A Novel Method to Improve Robustness of End Plate Connections at Elevated Temperatures Using Bolt Sleeves
Authors: Shaheen Mohamed A. , Cunningham Lee S. , Foster Andrew S. J. 
Published: April 2023

AbstractThe robustness of steel frames during fire events is primarily controlled by the rotational capacity of beam to column connections. Higher values of rotational capacity allow the beam to develop catenary action which enhances the survivability of the steel frame. The present study proposes a novel device to increase rotational capacity of steel end plate beam-column connections at elevated temperatures. By inserting a steel sleeve with a designated length, thickness and wall curvature between the end plate and the washer, the load path between the end plate and the bolts can be interrupted, promoting a more ductile response. An analytical solution predicting the sleeve design parameters is also presented. It is concluded that the proposed device can significantly increase the rotational capacity of the end plate connection at elevated temperatures. Furthermore, a detailed numerical investigation on end plate connections with various failure modes concluded that the proposed sleeve device does not have any negative effect on the connection performance at elevated temperatures.
Individual Differences and Situational Constraint Predict Information Search in Negotiation Planning
Authors: Le Dai Quy , Jang Daisung 
Published: April 2023

AbstractPlanning is critical for negotiation success as it facilitates obtaining superior outcomes. However, little empirically is known about this topic. We argue that individual differences are important to understanding planning behavior because planning affords greater opportunities for individual differences to manifest compared to other phases of negotiation. We conducted a series of studies with the aim of understanding how the Big Five factors and gender predict information search and preference while planning. In Study 1, we examined information search behavior using the Mouselab paradigm. When the search space was large, agreeableness predicted persistence in search, and women spent significantly more time on the task, and looked for value creating and relationship related information to a greater extent than men (Study 1a). In a more constrained situation or with a smaller search space, few associations between individual differences and search behavior emerged (Studies 1b and 1c). In Study 2, we used a survey design to elicit preferences for information type. In this task, multiple personality factors predicted preferences. Conscientiousness and openness predicted preferences for value claiming information, and women preferred value creating information. Conscientiousness predicted preference for value claiming choice of information through the preference for value claiming information. How individual differences manifest in information search and preference in negotiation planning is a function of both task type and complexity.
Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance
Authors: Shahine Yasmine , El-Aal Sarah A. Abd , Reda Ahmed M. , Sheta Eman , Atia Nouran M. , Abdallah Ossama Y. , Ibrahim Sherihan Salaheldin Abdelhamid 
Published: April 2023

Abstract
Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties. However, it has difficult physicochemical characteristics since its solubility demands a pH level of 12, which has an impact on the drug’s bioavailability. The aim of this work is the development and characterization of diosmin nanocrystals using anti-solvent precipitation technique to be used for topical treatment of psoriasis. Results revealed that diosmin nanocrystals stabilized with hydroxypropyl methylcellulose (HPMC E15) in ratio (diosmin:polymer; 1:1) reached the desired particle size (276.9 ± 16.49 nm); provided promising colloidal properties and possessed high drug release profile. Additionally, in-vivo assessment was carried out to evaluate and compare the activities of diosmin nanocrystal gel using three different doses and diosmin powder gel in alleviating imiquimod-induced psoriasis in rats and investigating their possible anti-inflammatory mechanisms. Herein, 125 mg of 5% imiquimod cream (IMQ) was applied topically for 5 consecutive days on the shaved backs of rats to induce psoriasis. Diosmin nanocrystal gel especially in the highest dose used offered the best anti-inflammatory effect. This was confirmed by causing the most statistically significant reduction in the psoriasis area severity index (PASI) score and the serum inflammatory cytokines levels. Furthermore, it was capable of maintaining the balance between T helper (Th17) and T regulatory (Treg) cells. Moreover, it tackled TLR7/8/NF-κB, miRNA-31, AKT/mTOR/P70S6K and elevated the TNFAIP3/A20 (a negative regulator of NF-κB) expression in psoriatic skin tissues. This highlights the role of diosmin nanocrystal gel in tackling imiquimod-induced psoriasis in rats, and thus it could be a novel promising therapy for psoriasis.

Graphical abstract
Teacher practices of verbal support during a design project in the chemistry classroom
Authors: Sheoratan Sathyam , Henze Ineke , de Vries Marc J. , Barendsen Erik 
Published: April 2023

AbstractDesign activities are gaining interest as rich contexts for learning science, technology, engineering, and mathematics (STEM) subjects. STEM teachers may find this challenging however, as designing requires support that they are not used to providing. In a subject like chemistry, teachers would have to balance creativity and responsibility for the students with concept learning and safety in the classroom. In a case study, we analyzed the verbal interactions of three teachers with their students during design activities in the classroom, with the aim of understanding what teachers and students talk about and how chemistry teachers support the students with their designs. During the lesson, students worked on the design of a self-heating or self-cooling cup, while also performing chemistry experiments to learn about the energy effects of reactions. Such a lesson reflects what design activities in the chemistry classroom could look like. We described the topics that teachers and students talk about, revealing that teachers support students through several types of feedback and questions. We also found that teachers support design tasks in a more open, constructive, and encouraging way than is used for experiments and chemistry concepts, which are supported in a closed, clarifying, and steering manner.
Lifecycle-dependent toxicity and removal of micropollutants in algal cultures of the green seaweed Ulva (Chlorophyta)
Authors: Hardegen Justus , Amend Gabriel , Wichard Thomas 
Published: April 2023

AbstractThe green marine seaweed Ulva (Chlorophyta) is widely suggested as a biofilter for cost-effective bioremediation in integrated multitrophic aquaculture and wastewater management. Micropollutants (MPs), including antibiotics, endocrine disruptors, and herbicides, can severely affect humans and the environment. As these compounds may be accumulated or transformed by Ulva, its simultaneous function as an efficient biofilter and as a food and feed source might be affected. Therefore, we investigated the removal of ten MPs often found in wastewater effluents by Ulva and its associated bacteria, and characterized the effects of these MPs on the alga during two crucial lifecycle phases (germination and vegetative growth) using dose dependent tests. We monitored MP detoxification at elevated concentrations in a reductionistic tripartite Ulva mutabilis-Roseovarius-Maribacter model system to reduce interference from the fluctuating algal microbiome. Our results showed that the tripartite community was resistant to the MPs tested, although the gametes were between 2 to 140 times more susceptible based on the half-effective concentrations (EC50) than the growing vegetative alga. The herbicide atrazine and the endocrine disruptor bisphenol A proved the most toxic MPs for germinating gametes. U. mutabilis and its associated bacteria could not eliminate the tested antibiotics and herbicides but efficiently reduced the concentration of endocrine disruptors, including bisphenol A, estradiol, and ethinylestradiol, by over 98% to below the detection limit. We also confirmed that Ulva is not likely to become contaminated under the studied exposure conditions because no biotic processes are used to remove the other MPs, which emphasizes yet another benefit of its use in aquaculture. Compared to green microalgae, U. mutabilis appears to be more resistant to micropollutants.
Bioactives from microalgae: A review on process intensification using hydrodynamic cavitation
Authors: Mittal Rochak , Ranade Vivek 
Published: April 2023

AbstractMicroalgae are emerging as an important renewable and sustainable source of high-value biomolecules having applications in food, cosmetics, pharmaceutical, agrochemicals and fuel industries. Deriving high-value biomolecules from micro-algae however faces numerous process and technological challenges. It is essential to develop innovative ways of intensifying processes used for valorising microalgae. Hydrodynamic cavitation (HC) offers an attractive platform for process intensification relevant to microalgae because of its scalability, ability to handle dense slurries, intense physicochemical effects, and low cost. Here we briefly review the overall processes involved in deriving high-value biomolecules from micro-algae. Opportunities for intensifying these processes and enhancing productivity of processing microalgae via HC are then identified and critically reviewed. The current state of the art and yet unresolved challenges are highlighted. An attempt is made to identify specific suggestions to help direct future research efforts. The review will be useful for researchers and practitioners aiming to harness HC for deriving high-value products from microalgae.
The Lived Experiences of Spousal Bereavement and Adjustment Among Older Chinese Immigrants in Calgary
Authors: Wang Qianyun , Walsh Christine A. , Tong Hongmei 
Published: April 2023

AbstractSpousal bereavement poses considerable challenges to adults in late life. Some populations, such as older immigrants, may experience heightened negative outcomes as a consequence of spousal bereavement, due to migratory stress and social isolation. Spousal bereavement is culturally embedded as it is related to cultural beliefs and attitudes concerning death and family relationships. However, studies on spousal bereavement or widowhood among older immigrants are extremely limited. This study aims to fill the gap by exploring, via a phenomenological approach, the lived experiences of widowed older Chinese immigrants in Calgary and responding to the question: What are the lived experiences of widowed Chinese older immigrants in coping with their spousal bereavement? With the data drawn from 12 in-depth qualitative interviews, findings were categorized into individual, family, community and societal levels. Study participants experienced long-lasting grief that was private and impacted by their culture and immigration status. Although family and ethno-cultural communities provided various types of supports during participants’ widowhood, they did not directly assist them in coping with spousal loss. Most participants did not access social services for bereavement support, more often relying on cultural rituals and faith practices. Findings suggest the need for culturally appropriate bereavement supports and family/community involvement for older immigrant adults who have experienced spousal loss.