bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crypto Asset as a Transaction Tool in the Perspective of Economic Analysis of Law: Legal Consequences and Ius Constituendum
Authors: Ningsih Dita Damayanti Sasmito , Achmad Dimas Hikari , Dewi Elreddian Kusuma , Purnami Yessy Arinta Puji 
Published: December 2022

This normative legal research examines the economic and legal aspects of using crypto assets as a means of business transactions in Indonesia. The study uses a concept and legislation approach to analyze the legal consequences of crypto assets as transaction tools in digital business transactions. The research finds that crypto assets can be traded as goods in accordance with existing regulations, but cannot be used as legal tender in digital business transactions. Any digital transaction that uses only crypto assets as currency is null and void, and subject to criminal sanctions. To regulate the use of crypto assets as transaction tools, the study suggests breaking down the substance of Bappebti Regulation into two characters, regeling and beshikking. The implication of this research is that further studies and proposals are needed from Bappebti to determine whether crypto assets can be used as currency in the future, and to ensure that future regulation aligns with the principles of Economic Analysis of Law.
Highlights:

Crypto assets can be traded as goods in accordance with regulations.
Crypto assets cannot be used as legal tender in digital business transactions.
Regulation of crypto assets as a transaction tool needs to be further developed and clarified.
Modal Sosial Kelompok Tani Lengkuas Dalam Meningkatkan Perekonomian Masyarakat Rubaru Sumenep Madura
Authors: Fadilatur Rahmah , Satriyati Ekna 
Published: December 2022

Abstrack Farmer cluster formation is to be effort for reaching the aim and also as way to share their opinion each other and their experience each other. Indirectly farmer cluster formation is a tool of social financial capital.it is because farmer cluster formation obtains society solidarity. The important quintessence in social financial capital is not only focus on the success which fixed by the farmer cluster it self but also from each person in that cluster. As well as society at Kaleleng village which majority society’s profession is as a farmer specifically in ginger plant that from farmer cluster. But, day by day society participation is lowering and it influence to their agriculture. The aim of this writing is to give information to the readers that social financial capital which formed by farmer cluster at Kaleleng village has important role in increasing society economy. It means society participant for optimizing farmer cluster in increasing economy collectively. This research is qualitative research in descriptive analytic by using society unit analysis which has a role in farmer cluster activity.
Inquiry Learning Model to Improve Student's Critical Thinking in the Themes Learning Technology Development in Class III SD IT Bina Insan Batang kuis
Authors: Mawarni Dina , Hidayat Hidayat 
Published: December 2022

This study aims to determine the success of the application of the inquiry learning learning model in increasing students' critical thinking in thematic learning of Theme 7 Technology Development in class III SD IT Bina Insan Batang Kuis. The design of this research is the Classroom Action Research (CAR) model of Kemmis and Mc. Taggart is a collaborative research conducted in 3 cycles. The data collection instruments were in the form of tests, observations, and interviews. Data analysis techniques in this study using qualitative and quantitative data. Based on the results of the study, it is known that before being given action in class, the percentage of critical thinking students is 35%, meaning that 9 out of 26 students who achieve a completeness score above the KKM 70. So the researchers took action by applying the inquiry learning model. The results of the application of the inquiry learning model run optimally as evidenced by the teacher's observations in the first cycle of 73.33 (enough), the second cycle increased by 83.33 (good) and experienced an increase in the third cycle of 93.33 (very good). The results of the first cycle of student observations from 66.66 (enough) to 87 (good) in the second cycle and obtained an increase of 90 (very good) in the third cycle. Students' critical thinking by applying the inquiry learning model to the first cycle, which obtained a completeness percentage of 53.84% (not critical), the second cycle increased to 84.61% (critical), and increased in the third cycle by 92.30% (very critical). The results of the research that researchers have done, can be seen in the acquisition of data from the cycle has increased. Thus it can be concluded that applying the inquiry learning model in thematic learning of Theme 7 Technology Development in class III SD IT Bina Insan Batang Kuis can improve students' critical thinking. Therefore, it is suggested that teachers can apply the inquiry learning model with the aim of improving students' critical thinking.
Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system
Authors: Wang Xiaoxue , Guo Yunxue , Tang Kaihao , Sit Brandon , Gu Jiayu , Chen Ran , Lin Jianzhong , Lin Shituan , Liu Xiaoxiao , Wang Weiquan , Gao Xinyu , Nie Zhaolong , Liu Tianlang , Waldor Matthew 
Published: December 2022

Abstract

Regulatory systems that maintain prophage quiescence integrate phage and host gene expression with environmental conditions1,2. In the opportunistic bacterial pathogen Pseudomonas aeruginosa, Pf filamentous bacteriophages play critical roles in biofilm formation and virulence3-5, but mechanisms governing Pf prophage activation in biofilms are largely unknown. Here, we report a new type of prophage regulatory module in a widely-distributed P. aeruginosa lineage that not only controls virion production of co-resident Pf prophages, but also mediates defense against diverse lytic phages. By comparing two lineages of the prototype P. aeruginosa strain PAO1 that harbor different Pf prophages, we identified a prophage-encoded kinase-kinase-phosphatase (KKP) system that controls Pf production in biofilms. KKP components exhibit dynamic stoichiometry, where high kinase levels in planktonic conditions maintain phosphorylation of the host H-NS protein MvaU, repressing prophage activation. During biofilm formation, phosphatase expression is heightened, leading to MvaU dephosphorylation and alleviating repression of prophage gene expression. KKP clusters are present in hundreds of diverse temperate prophages and other mobile elements across Gram-negative bacteria. Characterization of KKP modules from different species revealed that, in addition to regulating Pf phage lysogeny, KKP functions as a tripartite toxin-antitoxin system that mediates host defense from predatory lytic phages. KKP represents a new phosphorylation-based mechanism for prophage regulation and for phage defense. The dual function of this module raises the question of whether other newly described phage defense systems6-9 also regulate intrinsic prophage biology in diverse hosts.
A process evaluation of a pilot community health management information system in Mpongwe district of Zambia: lessons to inform strengthening of health information systems
Authors: Akinola Olatubosun , Zulu Joseph , Shakwelele Hilda , Mufana Carol , Banda Nelia , Katyoka Emmanuel , Chila Sylvia , Lubala Naomi 
Published: December 2022

Abstract
Background: Increased attention has been put towards developing and implementing Community Health Management Information System (c-HMIS). It is for this reason that in 2012, Ministry of Health (MoH) with the support from Clinton Health Access Initiative (CHAI) developed a Community Health Management Information System (c-HMIS) in Zambia. There is limited data on the implementation, acceptability and use of c-HMIS in community health systems. Guided by the by Atun’s framework on integration of interventions in health systems. We explored the implementation and acceptability of c-HMIS in Mpongwe district.
Methodology:Qualitative data collected with 66 respondents namely members of health committees, community health assistants and their supervisors were analysed using thematic analysis.
Results: The nature of the problem which included poor quality of data /information due to lack of standardized data collection tools and delayed submission of reports motivated MoH and stakeholders to adopt the c-HMIS. Theattributes of the c-HMIS Intervention such as the provision of improved data collection tools, training stakeholders in using the tools, the perceived simplicity of the system and factors within the adoption system such as some health workers being familiar with c-HMIS, compatibility of the c-HMIS with existing tools, as well as improved collaboration and communication among actors facilitated the adoption process. Further, health system characteristics such as timely availability of data and improved health information feedback processes, improved mapping of key health issues in communities; as well as the broader context such as community engagement promoted community ownership of the c-HMIS. The c-HMIS implementation barriers included challenges with completing some sections in the tools due to missing data, limited gender inclusiveness in the tools, inadequate availability of digital platforms to enter and store data, limited incentives for community health workers, poor phone network/ internet connection as well as the COVID-19 pandemic.
Conclusion: Strengthening the implementation and acceptability of c-HMIS may require introducing electronic data capture and transmission using simple digital tools such as android phones. Electronic systems would help address logical challenges related to inadequate data collection tools, data entry challenges, and delayed transmission of data.
Investigation of Group Dynamics in Video-conferencing Activity Facilitated by a Virtual Agent
Authors: Gordon Goren , Mizrahi Elinor , Danzig Noa 
Published: December 2022

Abstract
Small group activities have many educational advantages. In this contribution, we present a novel system for monitoring and analysing real-time group dynamics in a video-conferecing environment, with and without an autonomous virtual robot facilitator, which was programmed with group facilitation best practices. Groups of tenth-grade students interacted with the system, where we examined subjective perceptions of the activity, group dynamics and the facilitator, as well as analysed real-time speaker and facial expression recognition data. Our results show that students reported the activity with the virtual robot facilitator to be significantly more efficient, more understandable and more motivating of participation compared with activities without facilitation. Furthermore, students also spoke more, were happier and were significantly more engaged with virtual robot facilitation. Analyzing subjective and object measures showed significant correlations between the students' perceptions of the group activity and their own participation in it. Finally, it was found that group dynamics, as measured by time-series speaker and facial expression data, can be clustered into groups with similar behavioural characteristics and that facilitation with a virtual robot facilitator changed these dynamics. This study suggests that online group activities, facilitated by an autonomous virtual agent, are a promising tool to investigate group dynamics in educational scenarios.
Assessment of bacteriological quality of raw bulk milk of camel, cow and goat from local markets in Yabello District, Borana Zone, Oromia Regional State
Authors: Mohammed Temesgen , Zewude Aboma 
Published: December 2022

Abstract
Background: The study was conducted from September 2020 to June 2021to assess the bacteriological quality of raw bulkmilkfrom urban and rural local market sites in Borana pastoral area of Oromia Regional State, Southern Ethiopia. A total of 78 milk samples were collected and analyzed for bacterial load using standard plate count and coliform count techniques and isolation of pathogenic bacteria was conducted.
Results: The total mean aerobic bacterial counts of raw bulk milk samples of camel, cow and goat were 8.51 log cfu/ml, 8.73 log cfu/ml and 8.54log cfu/ml respectively. Regarding the location of milk market sites the mean total aerobic bacterial count was 8.72 log cfu/ml and 8.49 log cfu/mlin urban and rural milk market sites respectively. The total mean coliform counts of raw bulk milk samples of camel, cow and goat were6.51log cfu/ml, 6.55 log cfu/ml and 6.47 log cfu/ml respectively. Regarding the location of milk market sites the total mean coliform counts was 6.63 log cfu/ml and 6.40log cfu/ml from urban and rural milk market sites respectively.Comparing the mean differences of the total mean aerobic and coliform bacterial counts, there was no significant mean differences (p>0.05) among the animal milk samples. However, there was significant mean differences (p<0.05) among the milk market sites.
Conclusions: Different bacterial species were isolated from camel, cow and goat raw milk sample from the urban and rural milkmarket sites. The major bacterial isolates were Staphylococcus (both pathogenic and non-pathogenic), Escherichia coli and Bacillus species. Generally the unhygienic milk handling resulted in poor milk quality in the pastoral area. Therefore there is a need of training for persons at the various milk market siteson strict hygienic measures to improve the bacteriological safety of cow milk.
WITHDRAWN: SHOX variations in Idiopathic Short Stature in North India and its overall prevalence in Asia
Authors: Srivast Priyanka , Tyagi Ankita , Bamba Chitra , Kumari Anu , Kaur Harvinder , Seth Saurabh , Kaur Anupriya , Panigrahi Inusha , Dayal Devi , Pramanik Subhodip , Mandal Kausik 
Published: December 2022

Abstract
Background
Short stature homeobox (SHOX) haploinsufficiency underlies idiopathic short stature (ISS) and Leri-Weill dyschondrosteosis (LWD). The worldwide prevalence of SHOX variations in ISS varies from 2.5–15%. This study aims to assess the implication of SHOX variation in ISS in North India and its overall prevalence in Asian population.
Methods
SHOX gene analysis carried out by Multiplex ligation dependent probe amplification (MLPA) followed by Sanger sequencing in 54 patients with variable phenotypes. Meta-analysis was done to evaluate its prevalence which comprises 11 previous studies including present, carried out on a total of 979 participants.
Results
SHOX gene analysis resulted in 12.9% of positivity (7.4% deletions and 5.5% duplications). SHOX association was seen significantly related to gender, with predominance in female sex (P-value: 0.047). Short arms and forearms were the only significantly associated trait seen in 51.85% of children. We have found a rare association of multiple exostosis with LWD in a child with deletion. The prevalence of SHOX variation came as 15.2% in Asians. No significant difference was found in geographical region-specific analysis.
Conclusion
This meta-analysis compiles findings from the last decade and provides an updated picture of the prevalence of SHOX variations in Asians, emphasizing their potential as therapeutic targets in ISS patients.
Comparative effect of natural and chemical farming systems of apple production on soil physio-chemical properties, leaf mineral content and fruit quality
Authors: Pathania Sweta , Kumari Neelam 
Published: December 2022

AbstractThe present study was conducted to compare the effects of natural and chemical farming system of apple production on soil, leaf nutrient status and fruit quality. Experiment was conducted in ten commercial apple orchards; five under natural farming system of apple production and adjacent to them, five were under chemical farming system of apple production for comparison. Leaf nutrient status, soil physio-chemical properties and fruit quality under both the farming systems were evaluated. The results indicated significant difference in the primary (N, P, K) and secondary (Ca, Mg) macronutrient status of leaf and soil samples collected from the study orchards (p < 0.05). Among micronutrients, status of Cu and Zn were recorded to be significantly different in both the farming systems whereas, Fe and Mn were recorded to be non-significant. Soil pH and EC were recorded to be higher (6.12, 0.48 dS m− 1) in CFS than NFS (5.77, 0.38 dS m− 1), while OC was reported to be higher (2.03%) in NFS than CFS (1.78%). However, only OC was found to be significant. Fruit length, breath, weight and TSS showed significant difference in both the farming systems. Mean fruit length, breadth, weight, and acidity was recorded to be higher (65.80 mm, 71.62 mm, 159.65 g, 0.64%) in CFS than NFS (58.87 mm, 62.72 mm, 122.41 g, 0.48%). While firmness and TSS were recorded to be higher (6.95 kg inch− 2, 12.27 ᵒBrix) in NFS than CFS (5.64 kg inch− 2, 10.91 ᵒBrix). It can be concluded that nutrient status of soils and leaves was higher in CFS. This may be due to small sample size studied and the orchardists selected were practicing natural farming from only 4 years.
Clinical features and prognostic factors of adult patients with hemophagocytic lymphohistiocytosis: a retrospective study of 130 adult patients
Authors: Xu Tingting , Tang Liang V. , Xiong Lijuan 
Published: December 2022

Abstract
Background Hemophagocytic lymphohistiocytosis (HLH) is a syndrome with high mortality rate that is becoming increasingly common in adults in recent years. The mechanism of HLH in adults is poorly understood. This single-center study focused on the clinical features and prognostic factors of adult HLH patients.
Methods We reviewed the medical records of adult HLH patients (age≥15 years) diagnosed and treated at our institution from 2013 to 2022. Patients were followed from index date of prescription until death, or until August 31, 2022. Cox regression analysis was used to estimate hazard ratios (HR) and 95% confidence intervals (CI).
Results 130 (78 men, median age, 46 years) satisfied the HLH-2004 diagnostic criteria and were included in the study. 57 (43.8%) patients were malignancy-associated HLH. The median OS of the cohort was 61 days (95% CI 14–108). According to a multivariate Cox retrospective analysis, malignancy-associated HLH (HR=2.421, 95% CI 1.107–2.631, P=0.016) predicted a poorer outcome. Lower platelet count was related with both 30-day mortality (HR=0.987, 95% CI 0.976–0.998, P=0.018) and overall mortality (HR=0.993, 95% CI 0.987–0.999, P=0.019). The adoption of etoposide-related regimens reduced 30-day mortality (HR=0.453, 95% CI 0.252–0.815, P=0.008) and was strongly correlated with a better outcome (HR=0.629, 95% CI 0.407–0.972, P=0.037).
Conclusion Our study demonstrated that early diagnosis of HLH and identification of the underlying causes are crucial, low platelet count predicts poor outcome, and that therapy with etoposide dramatically improved prognosis.
Deep Learning Model on 2-Dimensional Image Data using Convolutional Autoencoder and Fully Connected Neural Networks: Application to Computational Fluid Dynamics
Authors: Yoon Jaehyun , Doh Jaehyeok 
Published: December 2022

Abstract
This study proposes a deep-learning-based image prediction meta-modeling method to develop an image-based approximate optimized design using 2D image data. An image-based meta-model is generated with an autoencoder (AE) and fully connected neural networks (FNN). To create this meta-model, we suggested three methods as FNN-based AE, convolutional autoencoder (CAE) based on convolution neural networks (CNN), and hybrid-convolutional autoencoder (H-CAE) combining the FNN and CAE. To verify the proposed methods, we applied them to predict the pressure distribution for around a 2-dimensional airfoil to replace the computational fluid dynamics simulation. As a result, the H-CAE among the proposed methods shows the high prediction accuracy, 99.9811% of the best image reconstruction rate for the pressure distribution around the airfoil. Therefore, H-CAE offers the best learning capability. There is an advantage that the latent can be predicted using shape parameters of an airfoil as inputs via the FNN based on the latent with the compressed image data.
Groundwater Risk Assessment in Imo River Basin of Southeast Nigeria using GIS-based DRASTIC and GOD
Authors: Emberga Terhemba , Opara Alexander , Onyekuru Samuel , Omenikolo Alexander , Bilar Ali , Unegbu Chika , Dominic Anuforo , Emeka Epuerie 
Published: December 2022

Abstract
Using the DRASTIC and GOD Techniques, a thorough evaluation of the aquifer vulnerability in the Imo River Basin, Southeast Nigeria, was conducted. The goal of the current study is to evaluate the two methods' capability for evaluating aquifer vulnerability in the study area by contrasting them. In contrast to the DRASTIC model, which assesses aquifer vulnerability using seven hydro-geological parameters, the GOD model estimates groundwater vulnerability across large regions based on just three parameters, including groundwater confinement, overlying strata, and depth to groundwater (depth to water, net recharge, aquifer media, soil media, topography, impact of vadose zone, and hydraulic conductivity). These index approaches used a variety of meteorological, geological, and hydro-geological observations to gather their data. The GOD and DRASTIC Indices were computed using sieve analysis to assess the hydraulic conductivity of the various strata covering the aquifers. The study's findings showed that the DRASTIC Index (DI) has a range of 76 to 192 with a mean value of 140.8. The Benin Formation has a mean DI of 162, which indicates high susceptibility, whereas the Ajali and Ameki Formations were determined to have average moderate vulnerabilities with DI values of 101 and 139, respectively. The Imo Shale, Ogwashi, and Nsukka Formations were calculated to have mean DI values of 76, 77, and 85, respectively, indicating modest aquifer vulnerability. The GOD Index across the study area ranged from 0.1 to 0.504 with a mean value of 0.328, it was also discovered. The mean GOD Index for the Benin Formation is 0.504, indicating high susceptibility, while the GOD Index values for the Ajali and Ameki Formations were assessed to be 0.105 and 0.112, respectively, indicating low vulnerability. Low vulnerability was identified for the Imo Shale, Nsukka, and Ogwasi Formations, with GOD Index values of 0.15,0125 and 0.1, respectively Due to its shallow aquifer depth and loose, uncompacted character, our data suggest that the Benin Formation has the highest vulnerability levels. Therefore, serious efforts should be made to keep an eye out for any potential anthropogenic pollution of the research area's aquifers.