bluuebunny/crossref_metadata_2025_split huggingface dataset:
Substance Abuse
Authors: Berman Carol W. 
Published: March 2023

Abstract
In Eugene O’Neill’s Long Day’s Journey Into Night, Mary, who is addicted to morphine, is the center of a dysfunctional family where drinking is also a problem. In The Iceman Cometh by O’Neill, a group of alcoholics try to deal with life and their longing for oblivion. Many other plays show us the outcome of alcoholism or drug addiction. Halfway Bitches Go Straight to Heaven, Stephen Adly Guirgis’s play is set in a women’s shelter that is filled with people who are addicted and mentally ill people. The playwright takes us into their psyches and steers us toward new pathways of thinking.
Paediatric, teenage, and young adult cancers
Authors: Ajithkumar Thankamma 
Published: March 2023

Abstract
Paediatric tumours are a varied spectrum of malignancies in children with different biology and clinical behaviour. The commonest paediatric malignancies are the leukaemias, followed by CNS tumours, lymphomas, and soft-tissue sarcomas. Approximately 70–80% of children with cancers are cured. However, &gt;70% of survivors are affected by long-term sequelae of treatment. Radiotherapy is only used when it cannot be replaced effectively by surgery and chemotherapy. Currently up to 50% of children receive radiotherapy. This chapter discusses the clinical and imaging features of paediatric tumours where radiotherapy is used and practical details on radiotherapy planning. It also summarizes the evidence underpinning current clinical practice.
End-of-life care
Authors: Harwood Rowan H. , Huwez Farhad Umer , Guyler Paul , Alam Sajid , Gaynor Catherine 
Published: March 2023

Abstract
This chapter discusses end-of-life care. Many stroke patients die, some soon after their stroke, particularly when the stroke is severe. But for the most part, care focuses on survival and recovery, which can cause problems. According to the WHO, palliative care is an approach that improves the quality of life of patients and their families facing problems associated with a life-threatening illness. The key principles of palliative care are meticulous management of symptoms, open communication, minimizing treatment burden, planning for the future, and supporting patients and their families. The chapter describes how these can be applied in stroke care, including what to do when prognosis is uncertain.
Outcomes and prognosis
Authors: Harwood Rowan H. , Huwez Farhad Umer , Guyler Paul , Alam Sajid , Gaynor Catherine 
Published: March 2023

Abstract
This chapter covers outcomes and prognosis after a stroke. Prediction of outcome can help manage expectations and make informed decisions on rehabilitation potential. We can track neurological and functional recovery but defining prognosis is complicated by inexorable attrition due to death, recurrence, complications, and intercurrent illness. The chapter describes survival rates and recurrences of stroke patients. About 40% of stroke survivors discharged from the hospital need help with basic activities of daily living, but the disabilities from stroke decline-over time.
Cognitive impairment after stroke
Authors: Harwood Rowan H. , Huwez Farhad Umer , Guyler Paul , Alam Sajid , Gaynor Catherine 
Published: March 2023

Abstract
This chapter explores cognitive impairment after stroke. Cognition comprises memory, orientation, reasoning, communication, and other thinking functions. Cognitive impairment is seen in many neurological disorders, so healthcare professionals managing stroke patients should be confident in assessing, diagnosing, and managing cognitive impairment. The chapter describes different causes including delirium, and vascular dementia, and also describes specific neurological deficits like aphasia, apraxia, and executive dysfunction. Management is predominantly supportive and functional. Close family involvement and individualization are needed to treat people with delirium and dementia.
Structure transformation from Sierpiński triangles to chains assisted by gas molecules
Authors: Li Chao , Xu Zhen , Zhang Yajie , Li Jie , Xue Na , Li Ruoning , Zhong Mingjun , Wu Tianhao , Wang Yifan , Li Na , Shen Ziyong , Hou Shimin , Berndt Richard , Wang Yongfeng , Gao Song 
Published: March 2023

ABSTRACT
Reversible transformations between fractals and periodic structures are of fundamental importance for understanding the formation mechanism of fractals. Currently, it is still a challenge to controllably achieve such a transformation. We investigate the effect of CO and CO2 molecules on Sierpiński triangles (STs) assembled from Fe atoms and 4,4″-dicyano-1,1′:3′,1″-terphenyl (C3PC) molecules on Au surfaces. Using scanning tunneling microscopy, we discover that the gas molecules induce a transition from STs into 1D chains. Based on density functional theory modeling, we propose that the atomistic mechanism involves the transformation of a stable 3-fold coordination Fe(C3PC)3 motif to Fe(C3PC)4 with an axially bonded CO molecule. CO2 causes the structural transformation through a molecular catassembly process.
Wastewater surveillance and an automated robot: effectively tracking SARS-CoV-2 transmission in the post-epidemic era
Authors: Ou Guanyong , Tang Yuxuan , Niu Shiyu , Wu Liwen , Li Shaxi , Yang Yang , Wang Jun , Peng Yun , Huang Chuanfu , Hu Wei , Hu Qinghua , Li Yinghui , Ping Yang , Lin Chao , Yu Boping , Han Qi , Hao Yabin , Luo Zhiguang , Tian Wende , Zhang Han , Liu Yingxia 
Published: March 2023

Abstract
Wastewater-based epidemiology (WBE) has exhibited great utility in the early and rapid identification of SARS-CoV-2. However, the efficacy of wastewater surveillance under China's previous strict epidemic prevention policy remains to be described. We collected the WBE data of wastewater treatment plants (WWTPs) in the Third People's Hospital of Shenzhen and several communities to determine the significant effectiveness of routine wastewater surveillance in monitoring the local spread of SARS-CoV-2 under tight containment of the epidemic. The results of 1 month of continuous wastewater surveillance showed that positive signals for SARS-CoV-2 RNA were detected in the wastewater samples, and a significant positive correlation was observed between the virus concentration and the number of daily cases. In addition, the community's domestic wastewater surveillance results were confirmed even 3 days before, or simultaneously with, the infected patient being confirmed as having the virus. Meanwhile, an automated sewage virus detection robot, ShenNong No.1 robot, was developed, showing a high degree of agreement with experimental data, offering the possibility of large-scale multi-point surveillance. Overall, our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.
Feasibility of using an app-based coaching intervention to improve provider communication about HPV vaccination
Authors: Grabert Brigid K , McRee Annie-Laurie , Henrikson Nora B , Heisler-MacKinnon Jennifer , Blasi Paula R , Norris Consuelo M , Nguyen Matthew B , Dunn John , McKeithen Mary Catharine , Gilkey Melissa B 
Published: March 2023

Abstract
Provider communication training is effective for increasing HPV vaccination rates among U.S. adolescents. However, such trainings often rely on in-person meetings, which can be burdensome for providers and costly to implement. To evaluate the feasibility of Checkup Coach, an app-based coaching intervention, to improve provider communication about HPV vaccination. In 2021, we offered Checkup Coach to providers in 7 primary care clinics in a large integrated delivery system. Participating providers (n = 19) attended a 1-h interactive virtual workshop that taught 5 high-quality practices for recommending HPV vaccination. Providers then had 3 months of access to our mobile app, which offered ongoing communication assessments, tailored tips for addressing parents’ concerns, and a dashboard of their clinic’s HPV vaccination coverage. Online surveys assessed pre-/post-intervention changes in providers’ perceptions and communication behaviors. Compared to baseline, more providers reported high-quality HPV vaccine recommendation practices at 3-month follow-up (47% vs. 74%, p &lt; .05). Providers’ knowledge, self-efficacy, and shared commitment to improving HPV vaccination also improved (all p &lt; .05). Although we found improvements in several other cognitions after the workshop, these changes did not retain statistical significance at 3 months. About three-quarters (78%) of providers used the mobile app, logging 2.3 sessions on average. Most providers agreed the app was easy to use (mean = 4.7/5.0), a convenient way to get vaccination data (mean = 4.6/5.0), and a tool they would recommend (mean = 4.3/5.0). Our app-based coaching intervention demonstrated feasibility and warrants additional evaluation as a novel mode for training providers to improve their HPV vaccine communication.
Integrating Text Messaging in a Low Threshold Telebuprenorphine Program for New York City Residents with Opioid Use Disorder during COVID-19: A Pilot Randomized Controlled Trial
Authors: Tofighi Babak , Badiei Beita , Badolato Ryan , Lewis Crystal Fuller , Nunes Edward , Thomas Anil , Lee Joshua D. 
Published: March 2023

Background
Pragmatic innovations are needed to optimize clinical outcomes among people who use opioids initiating buprenorphine. This pilot randomized controlled trial assessed the feasibility of integrating text messaging in a low threshold telebuprenorphine bridge program for people who use opioids during the COVID-19 pandemic.

Methods
Eligible adult patients with opioid use disorder inducted on buprenorphine (N = 128) in the NYC Health+Hospitals Virtual Buprenorphine Clinic between May and November 2020 were randomized to an automated texting intervention based on the medical management model versus treatment as usual. A participant feedback survey was administered at 8 weeks (n = 18). Primary outcomes consisted of acceptability (eg, study enrollment, engagement with the intervention) and feasibility (eg, lack of phone number and/or mobile phone ownership) of integrating texting in clinical care. A secondary outcome included retention in treatment at week 8 (ie, active buprenorphine prescription within the prior 7 days).

Results
Nearly all eligible patients consented to enroll in the study (90.8%) and few were excluded because of lack of mobile phone ownership (n = 27, 14.6%). Requests to discontinue receipt of texts (n = 6, 9.4%) was attributed to excessive message frequency, perceived lack of relevancy, and reduced interest in the intervention. Respondents completing the follow-up feedback survey were generally satisfied with the frequency of software-generated messages (14/18, 77.8%) and half shared text content with peers (9/18, 50%). There were no perceived issues with privacy, intrusiveness, or ease of use. Retention did not differ between participants randomized to the texting (M = 5.23 weeks, SD = 3.41) and treatment as usual groups (M = 4.98 weeks, SD = 3.34) at week 8 (P = 0.676).

Conclusions
This pilot randomized controlled trial confirms high acceptability and feasibility of integrating an automated texting tool in a telebuprenorphine bridge program. Future studies should assess whether text messaging may be efficacious when combined with staff contact and content addressing social determinants of health.
A Peer Recovery Coach Intervention for Hospitalized Patients with Opioid Use Disorder: A Pilot Randomized Controlled Trial
Authors: Suzuki Joji , Martin Bianca , Loguidice Frank , Smelson David , Liebschutz Jane M. , Schnipper Jeffrey L. , Weiss Roger D. 
Published: March 2023

Objectives
Patients with opioid use disorder (OUD) are increasingly being hospitalized for acute medical illnesses. Despite initiation of medications for OUD (MOUDs), many discontinue treatment after discharge. To evaluate whether a psychosocial intervention can improve MOUD retention after hospitalization, we conducted a pilot randomized controlled trial of a peer recovery coach intervention.

Methods
An existing peer recovery coach intervention was adapted for this trial. Hospitalized adults with OUD receiving MOUD treatment were randomized to receive either a recovery coach intervention or treatment-as-usual. For those in the intervention arm, the coach guided the participant to complete a relapse prevention plan, maintained contact throughout the 6-month follow-up period, encouraged MOUD continuation, and helped to identify community resources. Those receiving treatment-as-usual were discharged with a referral to outpatient treatment. Primary outcome was retention in MOUD treatment at 6 months. Secondary outcomes were the proportion of participants readmitted to the hospital and the number of days until treatment discontinuation and to hospital readmission.

Results
Twenty-five individuals who provided consent and randomized to the recovery coach intervention (n = 13) or treatment-as-usual (n = 12) were included in the analysis. No significant differences were found in the proportion of participants retained in MOUD treatment at 6 months (38.5% vs 41.7%, P = 0.87), proportion of participants readmitted at 6 months (46.2% vs 41.2%, P = 0.82), or the time to treatment discontinuation (log-rank P = 0.92) or readmission (log-rank P = 0.85).

Conclusions
This pilot trial failed to demonstrate that a recovery coach intervention improved MOUD treatment retention compared with treatment-as-usual among hospitalized individuals with OUD.
Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis
Authors: Tian Ye , Jellinek Matthew J. , Mehta Kritika , Seok Sun Mi , Kuo Shanny H. , Lu Wei , Shi Ruicheng , Lee Richard , Lau Gee W. , Kemper Jongsook Kim , Zhang Kai , Ford David A. , Wang Bo 
Published: March 2023

Background and Aims:
NASH, characterized by inflammation and fibrosis, is emerging as a leading etiology of HCC. Lipidomics analyses in the liver have shown that the levels of polyunsaturated phosphatidylcholine (PC) are decreased in patients with NASH, but the roles of membrane PC composition in the pathogenesis of NASH have not been investigated. Lysophosphatidylcholine acyltransferase 3 (LPCAT3), a phospholipid (PL) remodeling enzyme that produces polyunsaturated PLs, is a major determinant of membrane PC content in the liver.

Approach and Results:
The expression of LPCAT3 and the correlation between its expression and NASH severity were analyzed in human patient samples. We examined the effect of Lpcat3 deficiency on NASH progression using Lpcat3 liver-specific knockout (LKO) mice. RNA sequencing, lipidomics, and metabolomics were performed in liver samples. Primary hepatocytes and hepatic cell lines were used for in vitro analyses. We showed that LPCAT3 was dramatically suppressed in human NASH livers, and its expression was inversely correlated with NAFLD activity score and fibrosis stage. Loss of Lpcat3 in mouse liver promotes both spontaneous and diet-induced NASH/HCC. Mechanistically, Lpcat3 deficiency enhances reactive oxygen species production due to impaired mitochondrial homeostasis. Loss of Lpcat3 increases inner mitochondrial membrane PL saturation and elevates stress-induced autophagy, resulting in reduced mitochondrial content and increased fragmentation. Furthermore, overexpression of Lpcat3 in the liver ameliorates inflammation and fibrosis of NASH.

Conclusions:
These results demonstrate that membrane PL composition modulates the progression of NASH and that manipulating LPCAT3 expression could be an effective therapeutic for NASH.
Acupuncture for swallowing disorder after recovery from COVID-19: A protocol for systematic review and meta analysis
Authors: Xiao Yao , Lin Yueqi , Chen Qiqi , Wang Runyi , Li Zuming , Chen Daman , Huang Yuxin , Peng Guiyuan 
Published: March 2023

Background:
Swallowing disorder is a common sequela after recovery from COVID-19. Acupuncture is an important traditional therapy for treating swallowing disorder. However, the efficacy of acupuncture for swallowing disorder after recovery from COVID-19 lacks evidence-based medicine.

Methods:
All randomized controlled trials of acupuncture for swallowing disorder after recovery from COVID-19 will be retrieved and collected from December 2019 to November 2022 with no language restrictions. PubMed, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database, Chinese Biomedical Database, Chinese Science and Technology Journal Database (VIP), and the Wanfang Database will be searched. Two researchers will independently select studies, extract data, and evaluate study quality. The Cochrane risk of bias tool for randomized trials will be used to assess the risk of bias in the included studies. Statistical analyses will be performed using Review Manager version 5.3.

Results:
This study will provide a high-quality and convincing assessment of the efficacy and safety of acupuncture for swallowing disorder after recovery from COVID-19 and will be published in peer-reviewed journals.

Conclusion:
Our findings will provide a reference for future clinical decisions and guidance development.
Auricular therapy for primary dysmenorrhea: A protocol for systematic review and meta-analysis of randomized controlled trials
Authors: Yu Qianhui , Cao Jiazhen , Chen Hongxiu , He Jing , Wang Xinyue , Liu Renming , Li Tie 
Published: March 2023

Background:
Primary dysmenorrhea (PD) is a common problem among women. It is defined as any degree of perceived cramping pain during menstruation without any evident pathology. Auricular therapy (AT), a widely used alternative medical treatment method as part of traditional Chinese acupuncture, lacks reliable evidence to support its safety and effectiveness for PD. We aimed to conduct a meta-analysis to investigate the efficacy and safety of AT in PD and to investigate possible factors impacting the particular efficacy of AT in PD by meta-regression.

Methods:
This protocol followed the PRISMA guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. The following 9 sources will be searched for randomized control trials of AT for PD: the Cochrane Central Register of Controlled Trials, PubMed, Medline, Embase, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure, Chinese Science and Technology Periodicals (VIP) database and WanFang Database from inception to January 1, 2023. Primary outcomes include visual rating scales and clinical efficacy rates, while secondary outcomes include endocrine hormone indicators related to PD and adverse events. Two reviewers will work independently on study selection, data extraction, and coding, including the risk of bias assessment in the included studies. While conducting a meta-analysis, Review Manager version 5.3 will be employed. Otherwise, a descriptive analysis will be performed. The results will be displayed as a risk ratio with 95% confidence intervals for dichotomous data as well as weight mean difference or standardized mean difference with 95% confidence intervals for continuous data.

Results:
This study’s protocol will investigate the efficacy and safety of AT in the treatment of PD in a systematic way.

Conclusion:
This systematic evaluation will objectively and systematically assess the efficacy and safety of AT in PD based on the available evidence, as well as provides clinicians with evidence to support the treatment of the disease.
Caregiving experiences of stroke caregivers: A systematic review and meta-synthesis of qualitative studies
Authors: Wang Lingyu , Liu Jingyu , Wu Lingsha , Zhang Jing , Fang Haiyan 
Published: March 2023

Background:
Caregivers of stroke patients have demanding caregiving tasks and roles, and they face multiple challenges and a variety of needs in their caregiving process. This study aimed to systematically integrate and evaluate qualitative research data to understand the care experiences of caregivers of stroke patients and to provide them with targeted assistance.

Methods:
We critically assessed the study using the Joanna Briggs Institute Critical Assessment Checklist for Qualitative Research. Extraction, summarization and meta-synthesis of qualitative data. Qualitative studies related to this study were searched in PubMed, Web of Science, China National Knowledge Infrastructure, China Science and Technology Journal Database, China Biomedical Literature Database, and Wanfang Database by computer from the establishment of the database to February 2022. The method of tracing citations was used to find other articles that might be included to ensure the comprehensiveness of the search articles.

Results:
A total of 11 studies, including 167 participants, were included, and 40 research results were extracted, summarized into 8 new categories, and formed 2 meta-themes. Meta-theme 1: Caregivers had emotional struggles during caregiving but were still able to provide compassion and care for patients through positive coping. Meta-theme 2: caregivers faced many difficulties in the care process and were eager for support.

Conclusions:
Caregiving is a long and heavy process. Society, medical institutions, and families should pay full attention to the feelings and needs of stroke caregivers in the care process and provide appropriate support for them.
Plasma cell myeloma initially diagnosed as light-chain deposition disease on liver biopsy: A case report and literature review
Authors: Jeong Ji Yun , Yang Hyeon Tae , Cho Seung Hyun , Lee Yu Rim , Kim Jinhee , Kang Min Kyu , Hong Jihoon , Moon Joon Ho , Seo An Na 
Published: March 2023

Rationale:
Light-chain deposition disease (LCDD) is a rare condition characterized by the abnormal deposition of monoclonal light chains (LCs) in multiple organs, leading to progressive organ dysfunction. Herein, we report a case of plasma cell myeloma initially diagnosed as LCDD on liver biopsy performed for prominent cholestatic hepatitis.

Patient concerns:
A 55-year-old Korean man complained of dyspepsia as the main symptom. On abdominal computed tomography performed at another hospital, the liver showed mildly decreased and heterogeneous attenuation with mild periportal edema. Preliminary liver function tests revealed abnormal results. The patient was treated for an unspecified liver disease; however, his jaundice gradually worsened, prompting him to visit our outpatient hepatology clinic for further evaluation. Magnetic resonance cholangiography revealed liver cirrhosis with severe hepatomegaly of unknown cause. A liver biopsy was performed for the diagnosis. Hematoxylin and eosin staining revealed diffuse extracellular amorphous deposits in perisinusoidal spaces with compressed hepatocytes. The deposits, which morphologically resembled amyloids, were not stained by Congo red but stained strongly positive for kappa LCs and weakly positive for lambda LCs.

Diagnoses:
Therefore, the patient was diagnosed with LCDD. Further systemic examination revealed a plasma cell myeloma.

Interventions:
Fluorescence in situ hybridization, cytogenetics, and next-generation sequencing tested in bone marrow showed no abnormalities. The patient initially received bortezomib/lenalidomide/dexamethasone as the treatment regimen for plasma cell myeloma.

Outcomes:
However, he died shortly thereafter because of coronavirus disease 2019 complications.

Lessons:
This case demonstrates that LCDD may present with sudden cholestatic hepatitis and hepatomegaly, and may be fatal if patients do not receive appropriate and timely treatment because of delayed diagnosis. Liver biopsy is useful for the diagnosis of patients with liver disease of unknown etiology.