bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescription drug dependence with and without concurrent illicit drug use: a multicenter cross-sectional survey among an addiction treatment seeking population
Authors: Nawaz Asma , Nielsen Suzanne , Mehmood Tahir , Abdullah Abdullah , Ahmed Ali , Ullah Waseem , Khan Ahmad 
Published: June 2023

BackgroundDependence on prescription drugs and illicit drugs imposes a global health and social burden. Despite accumulating evidence of prescription drugs and illicit drugs dependence, none of the systematized studies has explored the magnitude of this problem in Pakistan. The aim is to investigate the extent and associated factors of prescription drug dependence (PDD), as opposed to concomitant prescription drug dependence and illicit drug use (PIDU), within a sample of individuals seeking addiction treatment.MethodsThe cross sectional study was conducted on the sample recruited from three drug treatment centers in Pakistan. Face-to-face interviews were conducted with participants who met ICD-10 criteria for prescription drug dependence. Several aspects like substance use histories, negative health outcomes, patient attitude, pharmacy and physician practices also collected to predict the determinants of (PDD). Binomial logistic regression models examined the factors associated with PDD and PIDU.ResultsOf the 537 treatment seeking individuals interviewed at baseline, close to one third (178, 33.3%) met criteria for dependence on prescription drugs. The majority of the participants were male (93.3%), average age of 31 years, having urban residence (67.4%). Among participants who met criteria for dependence on prescription drugs (71.9%), reported benzodiazepines as the most frequently used drug, followed by narcotic analgesics (56.8%), cannabis/marijuana (45.5%), and heroin (41.5%). The patients reported alprazolam, buprenorphine, nalbuphine, and pentazocin use as alternatives to illicit drugs. PDD was significantly negatively associated with injectable route (OR = 0.281, 95% CI, 0.079–0.993) and psychotic symptoms (OR = 0.315, 95% CI, 0.100, 0.986). This implies that PDD is less likely to be associated with an injectable route and psychotic symptoms in contrast to PIDU. Pain, depression and sleep disorder were primary reasons for PDD. PDD was associated with the attitude that prescription drugs are safer than illicit drugs (OR = 4.057, 95%CI, 1.254–13.122) and PDD was associated with being on professional terms (i.e., having an established relationship) with pharmaceutical drugs retailers for acquisition of prescription drugs.Discussion and conclusionThe study found benzodiazepine and opioid dependence in sub sample of addiction treatment seekers. The results have implications for drug policy and intervention strategies for preventing and treating drug use disorders.
Behind the scenes of the healthcare COVID-19 pandemic crisis: potential affecting factors of healthcare work sustainability in Romania during 2020–2022
Authors: Savu Cristina , Armaș Iuliana , Burcea Marin , Dobre Daniela 
Published: June 2023

AimThe COVID-19 pandemic represented a great disturbance for medical systems around the world, putting medical personnel on the front lines of the fight against the SARS-Cov2 virus. This fight was particularly impactful in countries with medical systems already facing various challenges, including Romania; where the pandemic unfolded in five waves that severely affected the psychological and physical well-being of medical professionals in terms of overload and continuous exposure to health threats. Against this background, our research aims to identify the mediating role of potential affecting factors of healthcare work sustainability during the change-related uncertainty conditions generated by the COVID 19 crisis. Dynamics and relations of nine carefully selected constructs were tracked along all five pandemic waves in Romania, which span from March 2020 to April 2022. The tested variables and constructs are perception of healthcare workers of their own state of health, their workplace safety, the work–family conflict, the satisfaction of basic needs, the work meaningfulness and work engagement, patient care, pandemic stress and burnout.MethodsThis cross-sectional study is based on an online snowball sampling of 738 health workers from 27 hospitals. Panel research is limited to a maximum of 61 respondents for two successive waves. The analytical part is built on means comparison of analysed variables between all five pandemic waves and an in-depth model to explain the relationships between the variables.ResultsThe results indicate statistically significant correlations between the perception of health risks and all selected factors excluding patient care, which seems to be above the own health perception. The factors’ dynamics was followed along all five pandemic waves. The developed model identified that one’s health status satisfaction is a mediator of the family–work conflict and, together, of work engagement. In turn, work engagement plays a significant role in satisfying basic psychological needs and supporting work meaningfulness. Also, work meaningfulness influences the satisfaction of basic psychological needs.DiscussionHealth workers with higher levels of positive perceived health are better at managing pandemic stress, burnout effects and work-family imbalances. Adaptive behaviors and attitudes towards COVID-19 pandemic threats could be identified in later pandemic waves due to the progress in terms of medical protocols and procedures.
Uptake and effectiveness of a mobile application for real-time reporting and quality assurance of decentralized SARS-CoV-2 testing in Uganda
Authors: Nansumba Hellen , Nambuya Proscovia , Wafula Jackson , Laiton Namutebi , Kadam Rigveda , Akinwusi Olukunle , Suleiman Khairunisa , Akugizibwe Paula , Ssewanyana Isaac 
Published: June 2023

BackgroundEffective management of the COVID-19 pandemic required rapid expansion of diagnosis. The introduction of antigen tests presented an opportunity to decentralize testing, but raised challenges with ensuring accurate and timely reporting of testing data, which is essential to guide the response. Digital solutions can help address this challenge and provide more efficient means of monitoring and quality assurance.MethodsUganda’s existing laboratory investigation form was digitized in the form of an Android-based application, eLIF, which was developed by the Central Public Health Laboratory and implemented in 11 high-volume facilities between December 2021 and May 2022. The app enabled healthcare workers to report testing data via mobile phone or tablet. Uptake of the tool was monitored through a dashboard that enabled real-time visibility into data being transmitted from sites, as well as qualitative insights from site visits and online questionnaires.Results and discussionA total of 15,351 tests were conducted at the 11 health facilities during the study period. Of these, 65% were reported through eLIF, while 12% were reported through preexisting Excel-based tools. However, 23% of tests were only captured in paper registers and not transmitted to the national database, illustrating the need for increased uptake of digital tools to ensure real-time data reporting. While data captured through eLIF were transmitted to the national database within 0–3 days (min, max), data transmitted through Excel were transmitted in within 0–37 days (min, max), and data for paper-based reporting took up to 3 months. The majority of healthcare workers interviewed in an endpoint questionnaire responded that eLIF improved timeliness of patient management, and reduced reporting time. However, some functions of the app were not successfully implemented, such as providing random selections of samples for external quality assurance and enabling seamless linkage of these data. Challenges arose from broader operational complexities, such as staff workload, frequent task-shifting and unexpected changes to facility workflows, which limited adherence to the envisioned study procedures. Ongoing improvements are needed to adjust to these realities, to strengthen the technology and support to healthcare workers using it, to optimize the impact of this digital intervention.
“Something very taboo”: a qualitative exploration of beliefs, barriers, and recommendations for improving mental health care and access for Hispanic adults in the Paso del Norte U.S.-Mexico border region
Authors: Mallonee Jason , Escalante Rosa , Robles Eden Hernandez , Tucker Christal 
Published: June 2023

BackgroundHispanic adults with mental health conditions in the United States experience disproportionate access to and utilization of professional mental health treatment. This is believed to be in part due to systemic barriers and challenges, difficulty accessing care, cultural factors, and stigma. Studies to date have failed to examine these specific factors within the unique context of the Paso del Norte U.S.-Mexico border region.MethodsFor this study, 25 Hispanic adults identifying primarily of Mexican descent participated in four focus groups exploring these topics. Three groups were facilitated in Spanish and one group in both English and Spanish. Focus groups followed a semi-structured format eliciting perspectives on mental health and mental illness, help-seeking, barriers and facilitators of help-seeking and treatment access, and recommendations for mental health agencies and providers.ResultsQualitative data analysis yielded the following themes: understanding of mental health and help-seeking; barriers to accessing care; mental health treatment facilitators; and recommendations for agencies, providers, and researchers.ConclusionFindings from this study support the need for innovative mental health engagement strategies to reduce stigma, increase understanding of mental health, foster support systems, reduce individual and systemic barriers to seeking and accessing care, and to continue to engage communities in mental health outreach and research.
Analysis of 13-valent pneumococcal polysaccharide conjugate vaccine among children born in Hangzhou from 2017 to 2021
Authors: Che Xinren , Chen Qinghua , Liu Yan , Gu Lintao , Lu Zhaojun , Gu Wenwen , Wang Jun , Jiang Wei , Du Jian , Zhang Xiaoping , Xu Yuyang , Zhang Xuechao , Wang Jing , Xie Qixin , Yang Yingying 
Published: June 2023

Background13-valent pneumococcal polysaccharide conjugate vaccine (PCV13) has been introduced in Hangzhou since 2017, whereas its current immunization state in children is not clear. Therefore, this study aims to describe the PCV13 vaccination distribution among children born in Hangzhou from 2017 to 2021 to provide data for reducing vaccination differences among different populations.MethodsDescriptive epidemiology was used for data analysis and PCV13 vaccination related information of children was collected from children vaccination management system of Zhejiang Province (ZJCVMS).ResultsAmong the 649,949 children born in Hangzhou from 2017 to 2021, 169,230 were vaccinated with an average full course vaccination rate of 26.0%. The full course vaccination rates in 5 years were different (P = 0.000) with an increasing trend (Pfortrend &lt; 0.01). The first dose vaccination rates were different in 5 years (P = 0.000) with an increasing trend (Pfortrend &lt; 0.01). The distribution of age when first dose PCV13 was administered varied, most people at 2 months and least people at 5 months. The full course vaccination rate varied by areas, highest in central urban areas and lowest in remote areas respectively (all P-value &lt; 0.05). Overall, the full course vaccination rate of PCV13 was higher in the registered residence population than the non-registered residence population, which was 136,693 (31.4%) and 32,537 (15.1%) respectively (P = 0.000). The full course vaccination rates were the same between men and women (P = 0.502), which was 87,844 for men (26.0%) and 81,386 for women (26.1%).ConclusionAlthough the number of people who received PCV13 full course vaccination and received the first dose vaccination showed yearly increasing trends in Hangzhou, the full course vaccination rate for the whole population was relatively low. In addition, the PCV13 vaccination rates also differed by geography and household registration status. Measures such as expanding vaccination publicity or including national immunization should be taken to increase vaccination rates and reduce the differences in vaccination among groups with different characteristics.
Short Report: Barriers and facilitators to parents' implementation of a transdiagnostic eHealth sleep intervention for children with neurodevelopmental disorders
Authors: Jemcov Anastasija , Rosenberg Lindsay , Tan-MacNeill Kim , Smith Isabel M. , Weiss Shelly K. , Corkum Penny 
Published: June 2023

BackgroundInsomnia is highly prevalent in children diagnosed with neurodevelopmental disorders (NDDs) and has negative effects on physical and mental health and wellbeing. Lack of evidence-based intervention programs and barriers to treatment (e.g., time/cost) reduce treatment access. To address these problems, the possibility was explored of modifying the Better Nights, Better Days intervention for typically developing (TD) children (BNBD-TD) to make it appropriate for children with NDD.AimsThe current study's aim was to examine qualitative data from exit interviews conducted during a usability study. Parents of children with NDD used BNBD-TD and reported on barriers and facilitators experienced while implementing the intervention.Methods/proceduresParticipants were 15 Canadian parents of children aged 4 to 10 years who were formally diagnosed with an NDD. Parents implemented the BNBD-TD intervention with their children and participated in a semi-structured exit interview to provide perspectives on their user experience.ResultsBased on an inductive thematic analysis, key facilitators included increased self-efficacy, positive outcomes for the family (e.g., improved sleep problems, parent validation), improved sleep related beliefs/attitudes, and increased motivation. Key barriers included time challenges, struggles when trying to improve sleep problems, and psychosocial factors with negative effects on implementation (e.g., burnout, stress, and/or exhaustion).Conclusions/implicationsBarriers and facilitators identified resulted in recommendations to include more program supports, including helping parents to plan for implementation success.
Integrative Taxonomy of the Gall Mite Nothopoda todeica n. sp. (Eriophyidae) from the Disjunct Afro-Australasian Fern Todea barbara: Morphology, Phylogeny, and Mitogenomics
Authors: Chetverikov Philipp E. , Craemer Charnie , Gankevich Vladimir D. , Zhuk Anna S. 
Published: June 2023

Eriophyoidea is a group of phytoparasitic mites with poorly resolved phylogeny. Previous studies inferred Eriophyidae s.l. as the largest molecular clade of Eriophyoidea, and Nothopodinae as the basal divergence of Eriophyidae s.l. We investigate the morphology and molecular phylogeny of Nothopoda todeica n. sp. (Nothopodinae, Nothopodini), associated with a disjunct Afro-Australasian fern Todea barbara (Osmundaceae) from South Africa. Our analyses (1) determine new erroneous sequences (KF782375, KF782475, KF782586) wrongly assigned to Nothopodinae instead of Phyllocoptinae, (2) confirm the basal position of Nothopodinae in Eriophyoidea s.l., (3) question the monophyly of the Colopodacini and Nothopodini tribes, and (4) show the nested position of African fern-associated Nothopoda within a clade dominated by Asian nothopodines from angiosperms, which implies (a) a secondary association of nothopodines with ferns and (b) no relation between geography (continents) and the phylogenetic relationships of Nothopodinae species. Finally, we obtained a first complete mitochondrial genome for Nothopodinae and revealed a new gene order in the mitogenome of N. todeica n. sp., notably deviating from those in other investigated eriophyoids. Our results contribute to resolving the phylogeny of Eriophyoidea and provide an example of an integrative study of a new taxon belonging to an economically important group of acariform mites.
Differentiation of the Organoleptic Volatile Organic Compound Profile of Three Edible Seaweeds
Authors: Moura Pedro Catalão , Fernandes Jorge Manuel , Diniz Mário Sousa , Fetter Viktor , Vassilenko Valentina 
Published: June 2023

The inclusion of seaweeds in daily-consumption food is a worthy-of-attention challenge due to their high nutritional value and potential health benefits. In this way, their composition, organoleptic profile, and toxicity must be assessed. This work focuses on studying the volatile organic compounds (VOCs) emitted by three edible seaweeds, Grateloupia turuturu, Codium tomentosum, and Bifurcaria bifurcata, with the aim of deepening the knowledge regarding their organoleptic profiles. Nine samples of each seaweed were prepared in glass vials, and the emitted headspace was analyzed, for the first time, with a gas chromatography—ion mobility spectrometry device, a highly sensitive technology. By statistically processing the collected data through PCA, it was possible to accurately differentiate the characteristic patterns of the three seaweeds with a total explained variance of 98%. If the data were pre-processed through PLS Regression, the total explained variance increased to 99.36%. The identification of 13 VOCs was accomplished through a developed database of compounds. These outstanding values in addition to the identification of the main emissions of VOCs and the utilization of a never-before-used technology prove the capacity of GC-IMS to differentiate edible seaweeds based solely on their volatile emissions, increase the knowledge regarding their organoleptic profiles, and provide an important step forward in the inclusion of these highly nutritional ingredients in the human diet.
Molecular and Serological Identification of Anaplasma marginale and Borrelia burgdorferi in Cattle and Ticks from Nuevo Leon, Northern Mexico
Authors: Ortiz-Ramírez José Ángel , Rodríguez-Rojas Jorge Jesús , Hernández-Escareño Jesús Jaime , Galan-Huerta Kame-A , Rebollar-Téllez Eduardo Alfonso , Moreno-Degollado Gustavo , Medina-De la Garza Carlos E. , Sánchez-Casas Rosa María , Fernández-Salas Ildefonso 
Published: June 2023

Ticks and tick-borne diseases affect livestock productivity and cause significant economic losses. Therefore, surveillance of these pathogens and vectors is paramount to reducing these effects in livestock. This study aimed to identify Anaplasma marginale and Borrelia burgdorferi sensu lato in ticks collected from cattle. Molecular biology techniques were utilized to identify A. marginale for both types of samples, i.e., ticks and bovine blood. Serology of cattle using indirect immunofluorescence assay (IFA) was conducted to determine antibodies to B. burgdorferi s.l. from seven locations in Nuevo Leon, Mexico, between 2015 and 2017. From 404 bovines, 2880 ticks were collected: Rhipicephalus microplus (2391 females and 395 males), Amblyomma spp. (51 females and 42 males) and Dermacentor variabilis (1 female). Rhipicephalus microplus represented the largest specimens captured, with 96.7% within the seven study sites. PCR processed only 15% (442) of tick samples to identify A. marginale. Field genera proportions were followed to select testing tick numbers. Results showed that 9.9% (44/442) of A. maginale infected the pooled tick species, whereas the highest percent corresponded to 9.4% (38/404) in R. microplus. Regarding the molecular analysis of blood samples, 214 of 337 (63.5%) were positive for A. maginale. In each of the seven locations, at least one bovine sample tested positive for A. maginale. Borrelia burgdorferi s.l. was not found either in the ticks or serum samples. Two A.marginale DNA nucleotide sequences obtained in this study were deposited in the GenBank with the following accession numbers OR050501 cattle, and OR050500 R.microplus tick. Results of this work point to current distribution of bovine anaplasmosis in northern Mexico.
Teoría de la modificabilidad cognitiva de Feuerstein, R. (1983) y su aplicación en el contexto escolar
Authors: Escudero Ela Cecilia López , Hoyos Levis Leonardo Lozano 
Published: June 2023

El presente trabajo analiza e indaga acerca de la pertinencia de Teoría de la modificabilidad cognitiva de Feuerstein y su aplicación en el contexto escolar. Para Feuerstein, R. (1983) el ser humano se considera como un organismo abierto al cambio, a la modificación, siempre que exista un mediador, en el caso de las instituciones educativas, el mediador es el docente investigador. El análisis de investigaciones afines a las intervenciones cognitivas, permitieron concluir, la necesidad de definir rutas metodológicas para determinar la incidencia de una intervención cognitiva para el desarrollo de las habilidades del pensamiento relacionadas con la comparación y la clasificación en los estudiantes de 3° grado de la Institución Educativa San Isidro.
A terceirização da hospedagem de sistema e armazenamento de dados da Polícia Militar do Paraná (PMPR)
Authors: De Oliveira Anderson Martins 
Published: June 2023

O desenvolvimento tecnológico e cenário pandêmico dos últimos dois anos foram catalisadores para os processos da área de gestão em Tecnologia da Informação (TI), visto que, muitas atividades, transações e serviços foram adaptados e realizados de forma remota e híbrida em diferentes segmentos da sociedade, sobretudo, valorizando a terceirização. Isso porque, a busca das empresas tem sido voltada para redução de custos, com uma visão de produção de e pensamento enxuto, ou seja, produzir mais com menos. O objetivo principal desse trabalho é mapear, avaliar e apontar como e de que forma os sistemas e dados da Polícia Militar do Paraná são hospedados e armazenados. Para entender um pouco mais sobre o assunto em questão, primeiramente foi realizado um breve levantamento bibliográfico dos últimos anos, sobre a temática, em seguida aplicado um questionário estruturado e protocolado, com perguntas abertas e fechadas a Diretoria de Desenvolvimento Tecnológico e de Qualidade (DDTQ) da PMPR. Com o objetivo de avaliar se é apropriado a realização desta atividade por meio de data centers. Os resultados encontrados a partir da literatura e das respostas do questionário, apontam que: os profissionais entendem o papel da gestão de TI, sabem a quantidade de sistemas e dados hospedados, apontam vantagens e desvantagens sobre a atividade realizada, conhecem os riscos e as dificuldades em manter um data center apontando assim uma necessidade de mão de obra; apontaram como os principais riscos à segurança, confiabilidade, conformidade regulatória com a Lei Geral de Proteção de Dados (LPGD); custos com a construção e manutenção de um data center e a dependência, limitando assim a flexibilidade e a capacidade de personalização da infraestrutura.
Comparação entre o uso de dexametasona e prednisolona para o tratamento da laringite aguda
Authors: Felizari Aline Garcia , Cavalcante Laís Acácio , Brito André Almeida , Da Costa Wallyson Ferreira , Lembrance Ana Julia Macedo , De Araújo Michelle Paz , Pinto Gabriela Costa , Neiva Ana Lara Sucupira de Matos 
Published: June 2023

A laringite é uma doença respiratória caracterizada por estridor inspiratório, tosse e rouquidão. Esses sintomas resultam de inflamação na laringe e nas vias aéreas subglóticas fazendo com que a tosse forte seja a marca registrada. Embora geralmente seja uma doença leve e autolimitada, pode ocorrer obstrução significativa das vias aéreas superiores e desconforto respiratório. Para que não haja maiores complicações, o tratamento deve ser instaurado de forma mais precoce. Dentre os medicamentos usados, o corticoide tem demonstrado uma redução significativa do tempo de internação e da necessidade de uma via área definitiva. Sendo assim nesse artigo abordaremos qual corticoide é mais eficiente nos casos propostos.