bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploration of suitable external quality assessment materials for serum C-peptide measurement
Authors: Deng Yuhang , Zhang Chao , Li Bingqiong , Wang Jing , Zeng Jie , Zhang Jiangtao , Zhang Tianjiao , Zhao Haijian , Zhou Weiyan , Zhang Chuanbao 
Published: May 2023

Abstract

Objectives
To find suitable external quality assessment (EQA) materials for serum C-peptide, we evaluated the commutability of five types of processed materials.

Methods
Seventy-four individual serum samples and 12 processed samples including three EQA samples currently in use, frozen human serum pools (FHSP), and three other kinds of processed samples were prepared by dissolving WHO International Standard Reagent for C-peptide (WHO ISR 13/146) in three different matrixes: 0.05 % bovine serum albumin, fetal bovine serum and human serum pools. Samples were analyzed using the isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) method and six widely used immunoassays. The commutabilities of processed materials were assessed according to the difference in bias approach recommended by the IFCC. And the short- and long-term stability of FHSP samples at different temperatures were also evaluated.

Results
Out of the five kinds of processed materials, FHSP samples were commutable on most assays. In contrast, the EQA materials currently in use were only commutable on a few immunoassays. Additionally, processed materials derived from WHO ISR 13/146 were found to be un-commutable on over half of immunoassays. The FHSP samples could be stably stored at 4 and −20 °C for at least 16 days, and at −80 °C for at least 1 year, but at room temperature only for 12 h.

Conclusions
With clarified commutability and stability information, the human serum pool samples along with the developed ID-LC-MS/MS method could be used in the EQA program to promote the comparability among laboratories for C-peptide measurement in China.
Prenatal diagnosis of non-mosaic sex chromosome abnormalities: a 10-year experience from a tertiary referral center
Authors: Wu Xiaoqing , Guo Danhua , Li Ying , Xie Xiaorui , Su Linjuan , Cai Meiying , Zheng Lin , Lin Na , Liang Bin , Huang Hailong , Xu Liangpu 
Published: May 2023

Abstract

Objectives
The aim of this study was to explore the frequency and profile of non-mosaic sex chromosome abnormalities detected in prenatal diagnosis over the past 10 years.

Methods
We retrospectively reviewed pregnancies diagnosed with non-mosaic sex chromosome abnormalities between January 2012 and December 2021, using karyotyping and/or single nucleotide polymorphism (SNP) array. Maternal age, indications for testing, and outcomes were recorded.

Results
Traditional karyotyping identified 269 (0.90 %) cases of non-mosaic sex chromosome abnormalities among 29,832 fetuses, including 249 cases of numerical abnormalities, 15 unbalanced structural abnormalities, and 5 balanced structural abnormalities. The overall detection rate of common sex chromosome aneuploidies (SCAs) was 0.81 %, with 47,XXY, 47,XXX, 47,XYY, and 45,X accounting for 0.32 , 0.19, 0.17, and 0.13 % respectively. All showed a fluctuating upward trend over the study period, except for 45,X. During the first five years (2012–2016), the major indication for testing was advanced maternal age (AMA), followed by abnormal ultrasound, abnormal noninvasive prenatal testing (NIPT), and abnormal maternal serum screening (MSS). In the second five years (2017–2021), the most frequent indication was abnormal NIPT, followed by AMA, abnormal ultrasound, and abnormal MSS. Among the 7,780 cases that underwent SNP array in parallel, an additional 29 clinically significant aberrations were detected. The most frequent aberration was a microdeletion in the Xp22.31 region, which was associated with X-linked ichthyosis.

Conclusions
Fetal sex chromosome abnormalities are important findings in prenatal diagnosis. The application of NIPT and SNP array technology has greatly improved the detection of SCAs and submicroscopic aberrations associated with sex chromosomes.
Crystal structure of trans-N
1,N
8-bis(2-cyanoethyl)-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, C22H42N6
Authors: Rabi Saswata , Dey Lucky , Rahman Ismail M. M. , Tiekink Edward R. T. , Roy Tapashi Ghosh 
Published: May 2023

Abstract
C22H42N6, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 8.3115(2) Å, b = 8.8263(2) Å, c = 9.7688(2) Å, α =

111.490

(
2
)

°

$111.490(2){}^{\circ}$

, β =

115.056

(
2
)

°

$115.056(2){}^{\circ}$

, γ =

93.681

(
2
)

°

$93.681(2){}^{\circ}$

, V = 583.25(3) Å3, Z = 1, R

gt
(F) = 0.0465, wR

ref
(F
2) = 0.1351, T = 294 K.
DEPREMDEN HASAR GÖREN BİNALARIN SEBEP OLDUĞU ZARARLARDAN KAYNAKLANAN HUKUKÎ SORUMLULUĞA GENEL BAKIŞ – II – HAKSIZ FİİL SORUMLULUĞU
Authors: AKKURT Sinan Sami 
Published: May 2023

Bu çalışma, 6 Şubat 2023'te meydana gelen ve Mart 2023 sonu itibariyle açıkla-nan resmî rakamlara göre Türkiye'de yaklaşık “kırksekiz bin” kişinin hayatını kaybetmesine yol açan Gaziantep ve Kahramanmaraş depremlerinden kaynak-lanan zararlardan muzdarip kişilerin ve bu kişilere hukukî çare aramakta olan çok sayıda hukukçunun hukuksal arayışlarına genel hatlarıyla ve fakat ivedilikle bir rehber oluşturmak amacıyla yapılan araştırmanın, haksız fiil sorumluluğuna ilişkin ikinci kısmıdır.
Sorumlular ve sorumluluk, genel olarak zarar görenlerle sorumluluk süjeleri arasındaki hukukî ilişkilere göre belirlendiği ve şekillendiği için, iki kısımdan oluşan çalışmanın bu ikinci kısmında deprem zararlarından kaynaklanan hak-sız fiil sorumluluğu üzerinde durulmuştur. Çalışmanın sözleşme sorumluluğu-na ilişkin ilk kısmı ise “Depremden Hasar Gören Binaların Sebep Olduğu Zararlardan Kaynaklanan Hukukî Sorumluluğa Genel Bakış – I – Sözleşme Sorumluluğu” adı altın-da ayrı bir makale olarak hazırlanmıştır
Dios como fundamento: la tópica trascendental
Authors: Jiménez Rodriguez A. 
Published: May 2023

El presente artículo trata de pensar el concepto de Dios en su respecto lógico (entendida aquí la lógica como ciencia de la verdad) estudiando el sentido de las subrepciones en el marco de la anfibología de los conceptos de reflexión de la primera Crítica kantiana. La operación de sustitución del lugar de Dios como fundamento de lo real por un Dios postulado permite poner en conexión esta cuestión con el problema más general de los límites del conocimiento.
El efecto de la poda de Acropora palmata como estrategia para la obtención de tejido vivo en acciones de restauración arrecifal
Authors: Padilla Souza Claudia , Navarro Espinoza Eduardo , García Medrano Diego , González Vázquez David , Gutiérrez Plata Sara , Ramírez Mata Eloy , Estrada Saldívar Nuria 
Published: May 2023

Introducción: Los arrecifes de coral son ecosistemas altamente degradados, por lo que ha sido necesario implementar acciones de restauración activa para recuperar su estructura y funcionamiento. Se ha implementado la propagación clonal para obtener fragmentos pequeños (~ 10 cm) de las ramas distales de colonias donadoras de corales de la especie Acropora palmata, para posteriormente fijarlos en el sustrato arrecifal, simulando el efecto de dispersión que ocurre de manera natural en esta especie, a lo que en este trabajo se denomina “dispersión asistida”. Sin embargo, es necesario evaluar los efectos de esta técnica como son: la cantidad de fragmentos que se puede obtener de cada colonia, el periodo de recuperación de tejido de las colonias donadoras y los fragmentos sembrados.
Objetivo: Evaluar el efecto de poda en las colonias donadoras estimando el porcentaje de tejido podado de colonias donadoras de A. palmata y su tasa de recuperación 30 meses después.
Métodos: Se realizaron cuatro monitoreos: antes, inmediatamente después de la poda, un mes después de la siembra, y 30 meses después, en cuatro colonias de A. palmata localizadas en el Parque Nacional Costa Occidental de Isla Mujeres, Punta Cancún y Punta Nizuc en el Caribe mexicano. La modelación 3D basada en fotogrametría se realizó con el software Agisoft Metashape Pro, mientras que las métricas de área de superficie de tejido, extensión radial y apical se obtuvieron mediante el software CloudCompare.
Resultados: Posterior a la colecta de fragmentos de las colonias, se observó que el material utilizado en la dispersión asistida representa menos del 12% del tejido vivo. Después de un mes, las colonias donadoras presentaban una recuperación del 5% con tejido nuevo recubriendo las áreas de corte. Las colonias donadoras perdieron, en promedio, 65% de tejido vivo tras el impacto de cuatro huracanes, y en un caso la colonia fue totalmente eliminada, pero con los fragmentos sembrados se pudo conservar el genotipo.
Conclusiones: La dispersión asistida podría incrementar el tejido vivo de corales ramificados en intervalos de tiempo relativamente cortos, sin comprometer la integridad de la colonia donadora, si se poda menos del 12%.
KI-Techniken für die Funktionale Sicherheit
Authors: Neumann-Mahlkau Jan , Bitner Arnold , Grigoleit Florian 
Published: May 2023

Die vorliegende Veröffentlichung beschreibt, wie KI hinsichtlich ihrer Zertifizierungsfähigkeit als qualifizierte Software für den Einsatz in sicherheitskritischen Anwendungen bewertet werden kann. Derzeit existiert dafür kein standardisierter Prozess. Als Beispiel wird der Concept Report für IEC 61508 und ISO 26262 des Softwaretools paitron von modelwise herangezogen. Die vom TÜV SÜD geforderten Analysen und Dokumente werden erläutert, aber auch was bei der Werkzeugentwicklung und -nutzung zu beachten ist, um erfolgreich ein sicherheitskritisches Werkzeug einzuführen. Die Ergebnisse dieser Arbeit beschäftigen sich darüber hinaus mit der aktuellen Diskussion über die Qualifizierung von KI, und inwieweit KI in der Funktionalen Sicherheit eingesetzt werden kann.
EFEKTIFITAS E-BOOK ENSIKLOPEDIA SERANGGA DENGAN STRATEGI MIND MAPPING UNTUK MELATIHKAN KETERAMPILAN BERPIKIR KREATIF SISWA
Authors: Cahyanti Amin Dwi , Sudibyo Elok , Rahayu Yuni Sri 
Published: May 2023

Abstrak. Perkembangan teknologi yang semakin maju, mempengaruhi proses pembelajaran yang mengaplikasikan perkembangan teknologi dan melatihkan keterampilan yang dibutuhkan di abad 21 yaitu keterampilan berpikir berpikir kreatif. E-book yang dikembangkan dengan strategi mind mapping, dilengkapi berbagai fitur yang dapat mendukung kreativitas siswa. Penelitian ini bertujuan untuk menghasilkan e-book ensiklopedia serangga dengan strategi mind mapping untuk melatihkan keterampilan berpikir kreatif kelas X SMA Negeri yang dinyatakan efektif. Keefektifan e-book ensiklopedia serangga ditinjau dari hasil belajar , keterampilan membuat mind mapping dan respon siswa. Metode yang digunakan adalah metode penelitian dan pengembangan (R&D) yang dimodifikasi dan dilakukan di Pascasarjana Sains Unesa pada bulan Juni 2020 – Februari 2021. Teknik pengambilan data melalui validasi, observasi, angket dan tes. Teknik analisis data dilakukan secara kuantitatif. Berdasarkan hasil penelitian diperoleh rata-rata skor hasil belajar siswa sebesar 82,60% dan nilai N gain sebesar 0,50 kategori sedang. Skor rata-rata keterampilan siswa membuat mind mapping sebesar 79 dengan kategori tinggi. Dan ditinjau berdasarkan keterampilan membuat mind mapping dengan rata-rata 79 kategori baik dan berdasarkan respon siswa (dengan hasil 99,46% merespon positif).Abstract. The development of increasingly advanced technology affects the learning process that applies technological developments and trains the skills needed in the 21st century, namely creative thinking skills. The e-book, which was developed with a mind mapping strategy, is equipped with various features that can support student creativity. This study aims to produce an insect encyclopedia e-book with a mind mapping strategy to practice creative thinking skills for class X SMA Negeri, which was declared effective. The effectiveness of the insect encyclopedia e-book in terms of learning outcomes, mind mapping skills and student responses. The method used is a modified research and development (R & D) method and was carried out at the Unesa Science Postgraduate in June 2020 - February 2021. The data collection technique was through validation, observation, questionnaires and tests. The data analysis technique was carried out quantitatively. Based on the results of the study, the average score of student learning outcomes was 82.60% and the N gain value was 0.50 in the medium category. The average score of students' mind mapping skills was 79 in the high category. And reviewed based on the skills of doing mind mapping with an average of 79 good categories and based on student responses (with the result of 99.46% responding positively).
PENYAJIAN KEANEKARAGAMAN MAKROZOOBENTOS DI SUNGAI BEREMBANG DALAM MEDIA PEMBELAJARAN ENSIKLOPEDIA PADA SUBMATERI INVERTEBRATA KELAS X SMA
Authors: Pristalika Yunike , Tenriawaru Andi Besse , Candramila Wolly 
Published: May 2023

Abstrak. The development of printed media in the form of an encyclopedia was carried out in this study to become a learning solution in schools that still have less IT facilities. Sub material of Invertebrate is one of the materials that is considered difficult because it contains a lot of material and unfamiliar terms, while the lesson hours are few. The inclusion of macro-zoo-benthos diversity in the encyclopedia media for use in schools located close to the aquatic ecosystem is believed to be able to provide more rich concepts for teachers to teach to their students. The success of developing the encyclopedia media as obtained in this study is expected to be able to answer the above problems while at the same time providing a variety of media for the school.Abstract. The development of printed media in the form of an encyclopedia was carried out in this study to become a learning solution in schools that still have less IT facilities. Sub material of Invertebrate is one of the materials that is considered difficult because it contains a lot of material and unfamiliar terms, while the lesson hours are few. The inclusion of macro-zoo-benthos diversity in the encyclopedia media for use in schools located close to the aquatic ecosystem is believed to be able to provide more rich concepts for teachers to teach to their students. The success of developing the encyclopedia media as obtained in this study is expected to be able to answer the above problems while at the same time providing a variety of media for the school.
KARAKTERISTIK MATERI PEMBELAJARAN SISTEM REPRODUKSI MANUSIA
Authors: Laksmi Monika Lintang , Prayitno Baskoro Adi , Indrowati Meti 
Published: May 2023

Abstrak. Artikel merupakan kajian literatur yang membahas mengenai karakterisktik sistem reproduksi manusia sebagai materi pembelajaran. Materi sistem reproduksi manusia seringkali dianggap tabu untuk diajarkan, terutama di Indonesia. Tujuan dari kajian literatur pada artikel ini adalah menganalisis karakteristik materi sistem reproduksi manusia, media pembelajaran pada sistem reproduksi manusia, keterkaitan antara guru dengan pembelajaran sistem reproduksi manusia, asesmen untuk menilai pemahaman siswa terhadap materi sistem reproduksi manusia, dan cara pemberdayaan pembelajaran sistem reproduksi manusia. Metode yang digunakan adalah pengkajian tentang literatur yang berkaitan dengan karakteristik materi sistem reproduksi manusia, literatur yang dikaji berasal dari tahun 2010 hingga 2022 yang berasal dari jurnal bertaraf nasional dan internasional. Hasil pengkajian literatur adalah diperlukan pemberdayaan dengan inovasi pada bahan ajar dan bentuk penilaian yang digunakan dalam materi sistem reproduksi manusia.Abstract. The article is a literature review that discusses the characteristics of the human reproductive system as a learning material. The material of the human reproductive system is often considered taboo to teach, especially in Indonesia. The purpose of the literature review in this article is to analyze the material characteristics of the human reproductive system, learning media in the human reproductive system, the relationship between teachers and human reproductive system learning, assessments to assess students' understanding of human reproductive system material, and how to empower human reproductive system learning. The method used is an assessment of literature related to the material characteristics of the human reproductive system, the literature studied is from 2010 to 2022 from national and international journals. The result of the literature review is that empowerment is needed with innovations in teaching materials and forms of assessment used in the material of the human reproductive system.
Antibiotic resistance pattern: a descriptive analysis at the general hospitals of Basra, Iraq during 2021
Authors: Mahmoud Rajaa Ahmed , Khalid Fadhil Abbas Al Rubaie  , Fadhila Imad Attwan Al Mahfoodh  
Published: May 2023

Antimicrobial resistance is a major problem in the new history of medicine all over the world. However, there are no previously available data on the exact situation or the extent of the problem in Basra to estimate the overall prevalence of antibiotic resistance by specifying it according to the causative organisms in Basra general hospitals during 2021. The study is a descriptive analysis that was conducted in 5 main hospitals in Basra, Iraq in 2021. Data related to the causative microorganisms and the antibiotic selection from 1384 patients were included. Overall, resistance against Penicillin G, Amoxicillin, Cefuroxime, and Cefixime was found to be the highest. Pneumonia, Enterococcus faecalis, and Proteus mirabilis were included in the study and found to be resistant to a wide range of antimicrobial agents. Overall, there is a high prevalence of antimicrobial resistance in Basra. And to address the problem, specific actions need to be taken at the individual, institutional, and national levels.
Keywords: Antibiotic; antimicrobial resistance; prevalence; hospitals.
Aprendizaje Facilitado por Docentes (AFPD): una metodología didáctica para el aprendizaje basado en el trabajo cooperativo
Authors: Ramirez Oswaldo Enrique , Arana Ruiz María Margarita , Kiyamu Tsuchiya Melisa , Mendoza Aquije Manuel , Dioses Flores Bertha 
Published: May 2023

Objetivo: se describe el AFPD y los niveles de satisfacción de los estudiantes acerca de esta metodología en dos cursos universitarios de biología. Se discute la importancia de los factores que condicionan el aprendizaje cuando se emplea el AFPD y las competencias que requieren tener los docentes que utilizan esta metodología. Caso: esta metodología promueve el aprendizaje a partir del trabajo en equipo donde los estudiantes transitan desde el estudio individual hacia uno cooperativo que les permite afianzar el aprendizaje a partir de reuniones de estudio con sus compañeros. El AFPD crea oportunidades para que los estudiantes contrasten sus aprendizajes, corrijan sus errores, discutan sus interpretaciones, enseñen y aprendan entre ellos, mejorando sus estrategias de aprendizaje y desarrollando habilidades sociales y personales. Los resultados sugieren que esta metodología ha sido positivamente valorada por los estudiantes. Las encuestas mostraron que alrededor de 85% de los estudiantes consideró que la metodología es excelente o buena y alrededor del 95% consideró que el desempeño del equipo docente fue excelente o bueno. El 93% de los estudiantes consideró que el nivel del curso fue adecuado para los estudiantes del primer año, y más del 90% de los estudiantes manifestaron haber quedado satisfechos o muy satisfechos con el desarrollo de las asignaturas. Conclusión : la aplicación del AFPD ha sido satisfactoria para los estudiantes de los cursos de biología y contribuye a la formación integral de los estudiantes.
A Hybrid Deep CNN-SVM Approach for Brain Tumor Classification
Authors: Biswas Angona , Islam Md. Saiful 
Published: May 2023

Background: Feature extraction process is noteworthy in order to categorize brain tumors. Handcrafted feature extraction process consists of profound limitations. Similarly, without appropriate classifier, the promising improved results can’t be obtained.
Objective: This paper proposes a hybrid model for classifying brain tumors more accurately and rapidly is a preferable choice for aggravating tasks. The main objective of this research is to classify brain tumors through Deep Convolutional Neural Network (DCNN) and Support Vector Machine (SVM)-based hybrid model.
Methods: The MRI images are firstly preprocessed to improve the feature extraction process through the following steps: resize, effective noise reduction, and contrast enhancement. Noise reduction is done by anisotropic diffusion filter, and contrast enhancement is done by adaptive histogram equalization. Secondly, the implementation of augmentation enhances the data number and data variety. Thirdly, custom deep CNN is constructed for meaningful deep feature extraction. Finally, the superior machine learning classifier SVM is integrated for classification tasks. After that, this proposed hybrid model is compared with transfer learning models: AlexNet, GoogLeNet, and VGG16.
Results: The proposed method uses the ‘Figshare’ dataset and obtains 96.0% accuracy, 98.0% specificity, and 95.71% sensitivity, higher than other transfer learning models. Also, the proposed model takes less time than others.
Conclusion: The effectiveness of the proposed deep CNN-SVM model divulges by the performance, which manifests that it extracts features automatically without overfitting problems and improves the classification performance for hybrid structure, and is less time-consuming.

Keywords: Adaptive histogram equalization, Anisotropic diffusion filter, Deep CNN, E-health, Machine learning, SVM, Transfer learning.
Development of Photothermal Catalyst from Biomass Ash (Bagasse) for Hydrogen Production via Dry Reforming of Methane (DRM): An Experimental Study.
Authors: Srinophakun Thongchai Rohitatisha , Kanchanakul Ittichai , Kuboon Sanchai , Kraithong Wasawat , Kaneko Hiroaki , Yamaguchi Akira , Miyauchi Masahiro 
Published: May 2023

Conventional hydrogen production, as an alternative energy resource, has relied on fossil fuels to produce hydrogen, releasing CO2 into the atmosphere. Hydrogen production via the dry forming of methane (DRM) process is a lucrative solution to utilize greenhouse gases, such as carbon dioxide and methane, by using them as raw materials in the DRM process. However, there are a few DRM processing issues, with one being the need to operate at a high temperature to gain high conversion of hydrogen, which is energy intensive. In this study, bagasse ash, which contains a high percentage of silicon dioxide, was designed and modified for catalytic support. Modification of silicon dioxide from bagasse ash was utilized as a waste material and the performance was explored of bagasse ash-derived catalysts interacting with light irradiation and reducing the amount of energy used in the DRM process. The results showed that the performance of 3%Ni/SiO2 bagasse ash WI was higher than that of 3%Ni/SiO2 commercial SiO2 in terms of the hydrogen product yield, with hydrogen generation initiated in the reaction at 300 °C. Using the same synthesis method, the current results suggested that bagasse ash-derived catalysts had better performance than commercial SiO2-derived catalysts when exposed to an Hg-Xe lamp. This indicated that silicon dioxide from bagasse ash as a catalyst support could help improve the hydrogen yield while lowering the temperature in the DRM reaction, resulting in less energy consumption in hydrogen production.