bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supplementary Figure 1 from High <i>BCR–ABL/GUS<sup>IS</sup></i> Levels at Diagnosis of Chronic Phase CML Are Associated with Unfavorable Responses to Standard-Dose Imatinib
Authors: Vigneri Paolo , Stagno Fabio , Stella Stefania , Cupri Alessandra , Forte Stefano , Massimino Michele , Antolino Agostino , Siragusa Sergio , Mannina Donato , Impera Stefana Stella , Musolino Caterina , Malato Alessandra , Mineo Giuseppe , Tomaselli Carmela , Murgano Pamela , Musso Maurizio , Morabito Fortunato , Molica Stefano , Martino Bruno , Manzella Livia , Müller Martin C. , Hochhaus Andreas , Raimondo Francesco Di 
Published: April 2023

<p>Figure 1.	Eight-year estimates, in an intention-to-treat analysis, for OS (solid line) and TFS (dashed line) in 272 CML patients receiving IM 400 mg/daily as first line therapy. At 60 months, OS was 93%, while TFS was 97.5%. Vertical lines indicate censored patients.</p>
Data from Phase I Clinical Study of Seneca Valley Virus (SVV-001),a Replication-Competent Picornavirus, in Advanced Solid Tumors with Neuroendocrine Features
Authors: Rudin Charles M. , Poirier John T. , Senzer Neil N. , Stephenson Joseph , Loesch David , Burroughs Kevin D. , Reddy P. Seshidhar , Hann Christine L. , Hallenbeck Paul L. 
Published: April 2023

<div>Abstract<p><b>Purpose:</b> Seneca Valley Virus (SVV-001) is a novel naturally occurring replication-competent picornavirus with potent and selective tropism for neuroendocrine cancer cell types, including small cell lung cancer. We conducted a first-in-human, first-in-class phase I clinical trial of this agent in patients with cancers with neuroendocrine features, including small cell lung cancer.</p><p><b>Experimental Design:</b> Clinical evaluation of single intravenous doses in patients with cancers with neuroendocrine features was performed across five log-increments from 10<sup>7</sup> to 10<sup>11</sup> vp/kg. Toxicity, viral titers and clearance, neutralizing antibody development, and tumor response were assessed.</p><p><b>Results:</b> A total of 30 patients were treated with SVV-001, including six with small cell carcinoma at the lowest dose of 10<sup>7</sup> vp/kg. SVV-001 was well tolerated, with no dose-limiting toxicities observed in any dose cohort. Viral clearance was documented in all subjects and correlated temporally with development of antiviral antibodies. Evidence of <i>in vivo</i> intratumoral viral replication was observed among patients with small cell carcinoma, with peak viral titers estimated to be >10<sup>3</sup>-fold higher than the administered dose. One patient with previously progressive chemorefractory small cell lung cancer remained progression-free for 10 months after SVV-001 administration, and is alive over 3 years after treatment.</p><p><b>Conclusions:</b> Intravenous SVV-001 administration in patients is well tolerated at doses up to 10<sup>11</sup> vp/kg, with predictable viral clearance kinetics, intratumoral viral replication, and evidence of antitumor activity in patients with small cell lung cancer. Phase II clinical evaluation in small cell lung cancer is warranted, and has been initiated. <i>Clin Cancer Res; 17(4); 888–95. ©2011 AACR</i>.</p></div>
Functional outcome of intertrochanteric fractures treated with trochanteric stabilizing plates
Authors: Shetty Sunil H. , Nagori Abdul Malik , Paneliya Manan B. , Sharma Vidur , Patil Digvijay S. , Shetty Aaishree 
Published: April 2023

Background: Intertrochanteric fractures account for significant percentage of health care costs and result in high rates of morbidity and mortality. Since higher rate of mortality and complications most fractures can be successfully treated with trochanteric stabilizing plates. This study was conducted to assess functional outcome in intertrochanteric fracture femur treated with trochanteric stabilizing plates and define ideal mode of fixation for such fractures. Trochanter stabilizing plate (TSP) is modular extension of dynamic hip screw (DHS) that is mounted on lateral femoral wall to stabilize greater trochanter. It provides the flexibility to achieve plate to bone apposition as well as axial compression or angular stability because of three screw fixations at the proximal fragment. TSF can provide a stress shield for the lateral trochanteric wall and prevent lateral migration of proximal fragments. Thus, TSF does not fail at the screw bone interface and provide a strong anchor in osteoporotic bone. The multiple locking screw holes of the TSF provide various options to tackle complex fracture pattern. It functions as an internalized external fixator and minimizes the pressure on the periosteum and encourages biological healing.
Methods: A total of 30 subjects of intertrochanteric fractures undergoing treatment with trochanteric stabilizing plates were taken up for the study after informed consent.
Results: Significant results were obtained using Harris hip score (HHS) at different postoperative follow up time intervals with good outcome and low complication rate.
Conclusions: Trochanteric buttress plate creates biomechanically stable construct by incorporating the comminuted trochanter it restores the proximal femoral anatomy, ensuring anatomical reduction hence subsequently reduces limb length discrepancy. We thus conclude this is an effective technique and has excellent functional and radiological outcomes with minimal complication and early rehabilitation rates. As Intertrochanteric fractures of the hip is a very common condition affecting a large number of patients of variable demographics and racial background, a more widespread study is required for a more conclusive study.
Analisis Pengendalian Persediaan Bahan Baku Pada CV. Yan Utama
Authors: Dita Alia Farah  , Gunarianto  , Khojanah Hasan  
Published: April 2023

Abstract
Control over the supply of raw materials is a must for every company that aims to avoid misuse in the form of fraud or waste, because in the business world problems often occur in carrying out production. The purpose of this study are as follows (1) to determine the raw material inventory control applied to CV. Yan Utama Corporation, (2) to determine the number of orders for CV raw material supplies. Yan Utama Corporation on economical order quantities. This research is a qualitative descriptive research, the location of this research is at CV. Main Yan Company Sidobakti street, Paregi Purwodadi Village. This research technique by way of observation, interviews, and documentation. Data analysis was carried out using a tabular approach and a formula approach. The result of this research is CV. Yan Utama controls the supply of pure chemical raw materials using the EOQ method. The number of orders for raw material inventory CV. Yan Utama on the EOQ is 2,936 kg of raw materials which can be ordered every time an order is placed. The frequency of purchasing raw materials in CV. Yan Utama when using the EOQ method which should or is more efficient is 7 times the purchase of raw materials in one period (1 year), while new orders are made by CV. Main Yan is 24 times a year. So that with this evaluation, the time to order raw materials can be more considered with an interval of every 51 days when ordering pure chemical raw materials.
Keywords: Inventory Control, Inventory Orders, Raw Materials.
La inteligencia emocional y el aprendizaje significativo
Authors: Huamanttupa Mamani Karina 
Published: April 2023

Desde hace más de 20 años se viene estudiando en múltiples investigaciones la relación entre la inteligencia emocional y el aprendizaje significativo. El objetivo del estudio fue analizar los factores que propician el desarrollo de la inteligencia emocional y su correlación con la obtención de un aprendizaje significativo. La metodología fue de diseño no experimental con un nivel descriptivo, realizándose una revisión documental sistemática comparándose las investigaciones desde 2017 hasta 2022 en las bases de datos de Scopus, Scielo, EBSCO, y Dialnet, utilizándose los booleanos AND y OR, adicionalmente para la ejecución de la revisión sistemática se siguió las sugerencias de la guía PRISMA. Como conclusión se propone estimular al estudiante a expresar con libertad sus opiniones, así como fomentar su autonomía y motivación intrínseca. Los docentes deben crear un ambiente acogedor, armonioso con dinámicas acordes, complementando sus conocimientos sobre la inteligencia emocional e incorporarlo a su labor pedagógica.
Resiliencia de docentes latinoamericanos en momentos de crisis
Authors: Nina Mallqui Rosario Carolina 
Published: April 2023

La resiliencia docente se refiere a la capacidad del profesional de la educación de hacer frente dentro del proceso de enseñanza y aprendizaje a las situaciones complejas. El estudio tuvo como objetivo el analizar la resiliencia en docentes latinoamericanos en momentos de crisis. Para ello, se usó el diseño de revisión sistémica, usando el protocolo PRISMA a través de un enfoque cualitativo, de análisis documental de estudios académico de carácter científico en relación a la resiliencia docente latinoamericana en tiempos de crisis. En conclusión, a través de los estudios seleccionados se válida el aporte clave del término resiliencia en los países latinos hacia los problemas de estrés generados por la virtualización en el proceso de enseñanza.
Utilization of chest imaging in COVID 19 pandemic
Authors: Nadeem Ahmed Rasha 
Published: April 2023

Introduction and Aim: Coronavirus disease (COVID-19) is a viral infection that can lead to severe respiratory disease. Radiological examinations mainly computed tomography (CT) and Chest x-ray (CXR) play a role in diagnosis, follow-up, and management of COVID-19 infection. The purpose of this study was to look into the extent of using chest imaging in COVID-19 infection, as well to see if chest imaging in COVID-19 infections is justified and guided by clinical recommendation in Mosul, Iraq.

Materials and Methods: This cross-sectional study involved 245 people (93 males and 152 females), infected previously with COVID-19 infection in Mosul, Iraq. The participants were asked to self-complete an anonymous questionnaire. Data obtained was subjected to statistical analysis.

Results: The 245 participants had an average age of 25.7 ±8.44 years. The study sample included 57 (23.2%) with low education and 188 (76.7%) with moderate to high education. Among the radiological examinations undergone by these participants, chest X-ray (CXR) was the most common followed by chest computed tomography scan (CT scan). The CXR and the CT scan were done during the patient's illness either for diagnosis or follow-up of the disease. Non-clinically recommended examinations were reported by 64% and 20% of patients who undertook CXR and CT scan respectively, during COVID-19 illness. Higher education status was associated with a tendency to do non-recommended CXR examination during COVID-19 infection.

Conclusion: CXR and CT imaging are the most commonly used radiological examinations in the diagnosis and follow-up in COVID-19 infection. However, a non-clinically recommended utilization of these examinations was noted in Mosul, Iraq during the pandemic. Therefore, educating people of this region about the limitation of non-justified uses of imaging is essential for healthy maintenance of individuals, environment, and resources.
Inventory policy for dense retail outlets
Authors: Ketzenberg Michael , Metters Richard , Vargas Vicente 
Published: July 2002

AbstractA potential retail operations strategy is to have a “dense” store. That is, a store that combines high product variety with a small footprint. Retail management desires smaller stores to provide the strategic benefits of convenience and speed to customers, but desires larger stores to provide high product variety. Noting the benefits of smaller, more numerous stores, several retailers well known for their extremely large store size recently have begun experimenting with a small store format. Traditional retail inventory management policies, however, have difficulty combining high variety and small store size. Here, the potential advantages of the dense store type are explored. To facilitate this exploration, inventory policies are developed to help manage small stores by increasing their product density. Results based on grocery industry data indicate that the heuristics compare favorably to optimality and permit the dense store concept to potentially achieve substantial gains compared to current practice.
Modeling Pore Size Distribution in Cellulose Rolled Stationary Phases
Authors: Keim Craig , Li Chenghong , Ladisch Christine M. , Ladisch Michael 
Published: July 2002

AbstractRolled stationary phases are fabrics (i.e., nonparticulate phases) that rapidly separate proteins from salts on the basis of size exclusion. Pore size and pore size distributions in the stationary phase determine how different size molecules distribute between the stationary and mobile phases in liquid chromatography columns. The potential for size exclusion chromatography by fabrics is not initially obvious because their interlaced structures are atypical for size exclusion supports. A simple logistic model fits the pore size distribution of a rolled stationary phase when pore sizes were measured using PEG, Dextran, D2O, glucose, and NaCl probes. When the fabric is treated with cellulase enzymes, the water‐accessible pores uniformly decrease and peak retention is lower. The logistic function model captures this result and enables comparison of pore size distribution curves between enzyme‐treated and untreated fabrics in rolled stationary phase columns.
Rates of combination antiretroviral treatment change in Australia, 1997–2000
Authors:   The Australian HIV Observational Database
Published: July 2002

Objective To estimate the rate of combination antiretroviral treatment change and factors associated with combination antiretroviral treatment change among patients recruited in the Australian HIV Observational Database (AHOD).Methods Analyses were based on patients in the AHOD who had commenced combination antiretroviral treatment after 1 January 1997. Combination antiretroviral treatment change was defined as the addition or change of at least one antiretroviral drug. A random‐effect Poisson regression model was used to assess factors associated with increased rates of combination antiretroviral treatment change.Results A total of 596 patients in the AHOD were included in the analysis, with a median follow‐up of 2.3 years. The overall rate of antiretroviral treatment change in this group was 0.45 combinations per year. In a multivariate analysis, a low CD4 count (< 200 cells/μL) at baseline was associated with an increased rate of treatment change [rate ratio (RR)=1.43; 95% confidence interval (CI), 1.13, 1.80; P=0.003)]. Combinations including a nonnucleoside reverse transcriptase inhibitor were also associated with slower rates of change than treatment combinations including a protease inhibitor (RR=0.64, 95% CI, 0.51, 0.80, P < 0.001).Conclusion Initiating combination antiretroviral at a CD4 cell count < 200 cells/μL may be associated with poorer patient outcomes. However, the possibility that clinician or patient concerns about low immunological status led to faster rates of treatment change in this group cannot be discounted.
Urinary Incontinence and Psychological Distress in Community‐Dwelling Older Adults
Authors: Bogner Hillary R. , Gallo Joseph J. , Sammel Mary D. , Ford Daniel E. , Armenian Haroutune K. , Eaton William W. 
Published: July 2002

OBJECTIVES: To examine the relationship between urinary incontinence (UI) and psychological distress in older adults. We hypothesized that persons with UI associated with condition‐specific functional loss would be most likely to report psychological distress.DESIGN: A population‐based longitudinal survey.SETTING: Continuing participants in a study of community‐dwelling adults who were initially living in East Baltimore in 1981.PARTICIPANTS: Persons aged 50 and older (n = 781) at follow‐up interviews conducted between 1993 and 1996 for whom complete data were available.MEASUREMENTS: Participants were classified as incontinent if they reported any uncontrolled urine loss within the 12 months preceding the 13‐year follow‐up interview. Condition‐specific functional loss secondary to UI was further assessed based on a series of questions relating directly to participants' inability to engage in certain activities due to their UI. Psychological distress was assessed using the General Health Questionnaire (GHQ) at interviews in 1981 and at the 13‐year follow‐up.RESULTS: Persons with UI were more likely to experience psychological distress as measured by the GHQ than were persons without UI (unadjusted odds ratio (OR) = 1.74, 95% confidence interval (CI) = 1.13–2.68). Persons with condition‐specific functional loss secondary to UI were substantially more likely to have psychological distress as measured by the GHQ than were persons without UI (unadjusted OR = 4.02, 95% CI = 1.86–8.70). In multivariate models that controlled for potentially influential characteristics such as age, gender, ethnicity, and chronic medical conditions the association between condition‐specific functional loss secondary to UI and psychological distress remained statistically significant. Among people with UI, persons with persistently elevated GHQ scores were much more likely to report condition‐specific functional impairment from UI (adjusted OR = 6.55, 95% CI = 1.94–22.12).CONCLUSION: Individuals with UI, especially when incontinence was associated with condition‐specific functional loss, were more likely to have psychological distress than were other older adults. Our findings support a general conceptual model that condition‐specific functional impairment mediates the relationship between a chronic medical condition and psychological distress.
Characteristics Associated with Fear of Falling and Activity Restriction in Community‐Living Older Persons
Authors: Murphy Susan L. , Williams Christianna S. , Gill Thomas M. 
Published: July 2002

OBJECTIVES:To identify the characteristics associated with restricting activity because of fear of falling (activity restriction) and to determine which characteristics distinguish older persons who restrict activity from those who have fear of falling but do not restrict their activities (fear of falling alone).DESIGN:Population‐based cross‐sectional study.SETTING:General community.PARTICIPANTS:One thousand sixty‐four community‐living persons aged 72 and older.MEASUREMENTS:Candidate predictors were identified from the following domains: demographic, health status, physical, psychosocial, and fall‐related. The outcome measure was the report of no fear of falling, fear of falling alone, or activity restriction.RESULTS:Fifty‐seven percent of the cohort reported no fear of falling, 24% reported fear of falling alone, and 19% reported restricting activity. The proportion of participants with poor health status, slow timed physical performance, activities of daily living disability, and poor psychosocial function was highest in those with activity restriction, intermediate in those with fear of falling alone, and lowest in those with no fear of falling. Of participants with fear of falling, characteristics independently associated with activity restriction were history of an injurious fall, slow timed physical performance, two or more chronic conditions, and depressive symptoms.CONCLUSION:Older persons who restrict activity are more physically frail and have a greater burden of chronic conditions and depressive symptoms than those who have fear of falling alone. These differences between persons with fear of falling may guide the refinement of clinical interventions and preventative programs. J Am Geriatr Soc 50:516–520, 2002.
Shear-thinning duct flow characteristics of relevance to stirred reactors
Authors: Pinho F. T. , Whitelaw J. H. 
Published: July 2002

Improvements in the performance of stirred reactors operating with non-Newtonian fluids under turbulent flow conditions require detailed knowledge of their fluid-mechanic properties. The complexity of stirred vessel flows, the large variety of flow configurations, and possible non-Newtonian fluids indicate that such an undertaking should be preceded by an investigation aimed at selecting the fluids and to assess transitional Reynolds number and non-Newtonian effects in the flows with characteristics of relevance to the process of stirring tanks. Mean and turbulent velocity characteristics of the flow of aqueous solutions of CMC (carboxymethyl cellulose) in a 25.4 mm diam duct, with and without a 50% area blockage disk located on its axis, were measured with a laser velocimeter. The polymer solutions at concentrations of 0.1% to 0.4% by weight were weakly elastic and shear-thinning. Water and a viscous Newtonian fluid were also investigated for comparison. The pipe flow measurements encompassing a range of Reynolds numbers from 240 to 111 000 quantify the delay in transition from laminar to turbulent flow caused by shear-thinning, the suppression of turbulence fluctuations particularly in the radial and tangential directions, and the reduction in the drag coefficient.
The baffle flow of Newtonian and non-Newtonian fluids was increasingly dependent on Reynolds numbers below 50 000 with the dampening of the normal Reynolds stresses also dependent on polymer concentration. At a Reynolds number 8000, the maximum values of turbulent kinetic energy with the 0.2% CMS and 0.4% CMC solutions were 35% and 45% lower than for water, respectively. Non-Newtonian effects are important in regions of low strain rates at low Reynolds numbers, and are represented by a decrease of turbulent diffusion and an increase of viscous diffusion, which would be enlarged by the effect of the elongational viscosity if higher than three times the viscometric viscosity. The performance of stirred vessel flows is likely to be impaired by the suppression of small-scale turbulence over the boundary layer of the blades and its possible early separation. A deterioration in the quality of micromixing is also likely to arise because of lower turbulence production in the shear layer of the jet emanating from the impeller. With strong shear-thinning fluids, the high viscosity in the large regions of low mean shear rate far from the impeller further contribute to turbulence suppression so that laminarizations of the flow may occur. However, the strong three-dimensionality of the mixer flow means that turbulence damping will occur for all Reynolds stresses rather than in preferential directions.