bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIW1 encoding a clade I PP2C phosphatase negatively regulates drought tolerance by de‐phosphorylating TaSnRK1.1 in wheat
Authors: Wang Jingyi , Li Chaonan , Li Long , Gao Lifeng , Hu Ge , Zhang Yanfei , Reynolds Matthew P. , Zhang Xueyong , Jia Jizeng , Mao Xinguo , Jing Ruilian 
Published: May 2023

AbstractDrought seriously impacts wheat production (Triticum aestivum L.), while the exploitation and utilization of genes for drought tolerance are insufficient. Leaf wilting is a direct reflection of drought tolerance in plants. Clade A PP2Cs are abscisic acid (ABA) co‐receptors playing vital roles in the ABA signaling pathway, regulating drought response. However, the roles of other clade PP2Cs in drought tolerance, especially in wheat, remain largely unknown. Here, we identified a gain‐of‐function drought‐induced wilting 1 (DIW1) gene from the wheat Aikang 58 mutant library by map‐based cloning, which encodes a clade I protein phosphatase 2C (TaPP2C158) with enhanced protein phosphatase activity. Phenotypic analysis of overexpression and CRISPR/Cas9 mutant lines demonstrated that DIW1/TaPP2C158 is a negative regulator responsible for drought resistance. We found that TaPP2C158 directly interacts with TaSnRK1.1 and de‐phosphorylates it, thus inactivating the TaSnRK1.1–TaAREB3 pathway. TaPP2C158 protein phosphatase activity is negatively correlated with ABA signaling. Association analysis suggested that C‐terminal variation of TaPP2C158 changing protein phosphatase activity is highly correlated with the canopy temperature, and seedling survival rate under drought stress. Our data suggest that the favorable allele with lower phosphatase activity of TaPP2C158 has been positively selected in Chinese breeding history. This work benefits us in understanding the molecular mechanism of wheat drought tolerance, and provides elite genetic resources and molecular markers for improving wheat drought tolerance.
Sufficient mesh polyhedral intralesional injection for treatment of keloids
Authors: Jiang Liya , Zhuang Jun , Su Xueshang , Zheng Qiaoyuan , Hu Jintian 
Published: May 2023

AbstractBackgroundThe recurrence of keloids after intralesional injections is significant, and a review of the literature shows an inconsistent range of success rates. In this study, the modified medical proportion and intralesional injection method were intended to enhance the treatment effect.MethodsTwenty patients completed the study. Regional block anesthesia (lidocaine, ropivacaine) was performed. Triamcinolone acetonide (40 mg/mL), 5‐fluorouracil (25 mg/mL), and ropivacaine (7.5 mg/mL) were configured in a ratio of 2:1:4 and applied on the lesion by reticular injection (horizontal fan‐shaped stratified and vertical shaking pressurized injection). The minimum volume of injection per square centimeter was approximately 3.5 mL. The outcome indicators were the Vancouver Scar Scale (VSS), Visual Analogue Scale (VAS), treatment frequency.ResultsThe patients had an 82% ± 7% average reduction in VSS scores and 89% ± 13% and 93% ± 10% reductions in VAS scores of pain and pruritus, respectively, after an average of 2.5 ± 0.7 injections administered within 1 year.ConclusionThe sufficient mesh polyhedral intralesional injection can achieve excellent results for the treatment of keloid scars.
The pennate diatom Pseudo‐nitzschia multistriata as a model for diatom life cycles, from the laboratory to the sea
Authors: Ferrante Maria Immacolata , Broccoli Andrea , Montresor Marina 
Published: May 2023

AbstractPhytoplankton dynamics are regulated by external cues, such as light and nutrients, as well as by biotic interactions and endogenous controls linked to life cycle characteristics. The planktonic pennate diatom Pseudo‐nitzschia multistriata, with a heterothallic mating system with two opposite mating types (MTs), represents a model for the study of diatom life cycles. P. multistriata is a toxic species, able to produce the neurotoxin domoic acid. First described in Japan in 1993, it was detected at the long‐term monitoring station MareChiara (Gulf of Naples, Italy) in 1995. Since then, P. multistriata has been reported from several worldwide coastal sites. A large body of knowledge has been produced on its ecology, genetic diversity, and life cycle characteristics. The availability of these data, the ecological relevance of the Pseudo‐nitzschia genus, and its controllable life cycle with a short generation time made it an ideal species to develop a genetic model system for diatoms. To enable functional studies, a 59 Mb genome sequence and several transcriptomic data were produced, and genetic transformation was optimized. These tools allowed the discovery of the first mating‐type determining gene for diatoms. Gene expression studies and metabolomics analyses defined genes and molecules underpinning different phases of the process of sexual reproduction. This model system, developed to explore the genetics of diatom life cycles, offers the opportunity to parallel experimental observations in the laboratory using in situ meta‐omics analyses along space and time, empowering knowledge on the biology and ecology of the genus.
Daytime affect and sleep EEG activity: A data‐driven exploration
Authors: Zhang Jin‐Xiao , ten Brink Maia , Yan Yan , Goldstein‐Piekarski Andrea , Krause Adam J. , Manber Rachel , Kreibig Sylvia , Gross James J. 
Published: May 2023

SummaryIt has long been thought that links between affect and sleep are bidirectional. However, few studies have directly assessed the relationships between: (1) pre‐sleep affect and sleep electroencephalogram (EEG) activity; and (2) sleep EEG activity and post‐sleep affect. This study aims to systematically explore the correlations between pre‐/post‐sleep affect and EEG activity during sleep. In a community sample of adults (n = 51), we measured participants' positive and negative affect in the evening before sleep and in the next morning after sleep. Participants slept at their residence for 1 night of EEG recording. Using Fourier transforms, the EEG power at each channel was estimated during rapid eye movement sleep and non‐rapid eye movement sleep for the full range of sleep EEG frequencies. We first present heatmaps of the raw correlations between pre‐/post‐sleep affect and EEG power during rapid eye movement and non‐rapid eye movement sleep. We then thresholded the raw correlations with a medium effect size |r| ≥ 0.3. Using a cluster‐based permutation test, we identified a significant cluster indicating a negative correlation between pre‐sleep positive affect and EEG power in the alpha frequency range during rapid eye movement sleep. This result suggests that more positive affect during the daytime may be associated with less fragmented rapid eye movement sleep that night. Overall, our exploratory results lay the foundation for confirmatory research on the relationship between daytime affect and sleep EEG activity.
The rate of adaptive molecular evolution in wild and domesticated Saccharomyces cerevisiae populations
Authors: Raas Maximilian W. D. , Dutheil Julien Y. 
Published: May 2023

AbstractThrough its fermentative capacities, Saccharomyces cerevisiae was central in the development of civilisation during the Neolithic period, and the yeast remains of importance in industry and biotechnology, giving rise to bona fide domesticated populations. Here, we conduct a population genomic study of domesticated and wild populations of S. cerevisiae. Using coalescent analyses, we report that the effective population size of yeast populations decreased since the divergence with S. paradoxus. We fitted models of distributions of fitness effects to infer the rate of adaptive () and non‐adaptive () non‐synonymous substitutions in protein‐coding genes. We report an overall limited contribution of positive selection to S. cerevisiae protein evolution, albeit with higher rates of adaptive evolution in wild compared to domesticated populations. Our analyses revealed the signature of background selection and possibly Hill–Robertson interference, as recombination was found to be negatively correlated with and positively correlated with . However, the effect of recombination on was found to be labile, as it is only apparent after removing the impact of codon usage bias on the synonymous site frequency spectrum and disappears if we control for the correlation with , suggesting that it could be an artefact of the decreasing population size. Furthermore, the rate of adaptive non‐synonymous substitutions is significantly correlated with the residue solvent exposure, a relation that cannot be explained by the population's demography. Together, our results provide a detailed characterisation of adaptive mutations in protein‐coding genes across S. cerevisiae populations.
The philosophical way of life as sub‐creation
Authors: Kramer Eli 
Published: May 2023

AbstractRichard Shusterman's Philosophy and the Art of Writing suggests something vital about the tension between philosophical discourses that cannot capture or be the full meaning of living a life in relation to wisdom, and lived philosophies that cannot do away with discourses to deepen a lived experience beyond them: that philosophy as “an embodied way of life” is a sub‐creation that emerges from the tension between them. This paper uses several different moments and ideas from Philosophy and the Art of Writing as points of departure for further inquiry. Some “memories,” repurposed, reorganized, and manipulated, take up these starting points to further the investigation. The present work was a spiritual exercise for the author and, one hopes, will be for the reader in what it means to practice philosophy as a way of life. By doing so, we may find more forgiveness and appreciation for our philosophical vocation that creates something more than what we say or are now.
Simulated microgravity altered the proliferation, apoptosis, and extracellular matrix formation of L929 fibroblasts and the transforming growth factor‐β1/Smad3 signaling pathway
Authors: Yue Yuan , Yang Jia‐Qi , Lu Sheng‐Yu , Ge Jun , Nie Hong‐Yun , Liu Kai‐Ge , Liu Fei , Li Hao , Yan Hong‐Feng , Zhang Tao , Sun Pei‐Ming , Sun Hong‐Wei , Yang Jian‐Wu , Zhou Jin‐Lian , Cui Yan 
Published: May 2023

AbstractExposure to microgravity can adversely affect the fitness of astronauts. The integrity of the skin plays a crucial role in protecting against mechanical forces and infections, fluid imbalance, and thermal dysregulation. In brief, the skin wound may cause unknown challenges to the implementation of space missions. Wound healing is a physiological process that relies on the synergistic action of inflammatory cells, extracellular matrix (ECM), and various growth factors to maintain the integrity of skin after trauma. Fibroblasts are present almost throughout the entire process of wound repair, especially in the scar formation at the endpoint of wound healing. However, there is limited knowledge about the extent to which fibroblasts are affected by the lack of gravity during wound healing. In this study, we utilized the rotary cell culture system, a ground‐based facility that mimics the weightless condition, to study the alterations of L929 fibroblast cells under simulated microgravity (SMG). Our results demonstrated that the SM condition exerted negative influences on the proliferation and ECM formation of the L929 fibroblast. Whereas, the apoptosis of fibroblast was significantly upregulated upon exposure to SMG conditions. Moreover, the transforming growth factor‐β1/Smad3 (TGF‐β1/smad3) signaling pathway of L929 fibroblast related to wound repair was also altered significantly under a weightless environment. Overall, our study provided evidence that fibroblasts are strongly sensitive to SMG and elucidated the potential value of the TGF‐β1/Smad3 signaling pathway modulating wound healing in the future practice of space medicine.
Semantic similarity measure of natural language text through machine learning and a keyword‐aware cross‐encoder‐ranking summarizer—A case study using UCGIS GIS&T body of knowledge
Authors: Tian Yuanyuan , Li Wenwen , Wang Sizhe , Gu Zhining 
Published: May 2023

AbstractInitiated by the University Consortium of Geographic Information Science (UCGIS), the GIS&T Body of Knowledge (BoK) is a community‐driven endeavor to define, develop, and document geospatial topics related to geographic information science and technologies (GIS&T). In recent years, GIS&T BoK has undergone rigorous development in terms of its topic re‐organization and content updating, resulting in a new digital version of the project. While the BoK topics provide useful materials for researchers and students to learn about GIS, the semantic relationships among the topics, such as semantic similarity, should also be identified so that a better and automated topic navigation can be achieved. Currently, the related topics are either defined manually by editors or authors, which may result in an incomplete assessment of topic relationships. To address this challenge, our research evaluates the effectiveness of multiple natural language processing (NLP) techniques in extracting semantics from text, including both deep neural networks and traditional machine learning approaches. Besides, a novel text summarization—KACERS (Keyword‐Aware Cross‐Encoder‐Ranking Summarizer)—is proposed to generate a semantic summary of scientific publications. By identifying the semantic linkages among key topics, this work guides the future development and content organization of the GIS&T BoK project. It also offers a new perspective on the use of machine learning techniques for analyzing scientific publications and demonstrates the potential of the KACERS summarizer in semantic understanding of long text documents.
Design and rationale for the Japanese Registry of Rivaroxaban Effectiveness & Safety for the Prevention of Recurrence in Patients with Deep Vein Thrombosis and Pulmonary Embolism (J’xactly) study
Authors: Okumura Yasuo , Fukuda Ikuo , Nakamura Mashio , Yamada Norikazu , Takayama Morimasa , Maeda Hideaki , Yamashita Takeshi , Ikeda Takanori , Mo Makoto , Yamazaki Tsutomu , Hirayama Atsushi 
Published: May 2023

Introduction
Rivaroxaban, a factor Xa inhibitor used as a direct oral anticoagulant, is beneficial over warfarin in terms of food–drug interactions and the need for therapeutic monitoring in patients with acute venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Because there is little data regarding VTE treatment in Japan, a real-world survey of Japanese patients being treated with rivaroxaban for VTE is needed.

Methods and analysis
The Japanese Registry of Rivaroxaban Effectiveness & Safety for the Prevention of Recurrence in Patients with Deep Vein Thrombosis and Pulmonary Embolism has been established to investigate the clinical outcomes of rivaroxaban for the initial treatment and prevention of symptomatic recurrent VTE in Japanese patients with acute symptomatic/asymptomatic VTE. 150 institutions in Japan will enrol patients in the study; the target enrolment is 1000. All patients will be followed up two times a year for at least 18 months and up to 3 years after their enrolment. The primary outcome is symptomatic recurrent VTE occurring during the study period. The principal safety outcome is clinically relevant bleeding (ie, major bleeding or clinically relevant non-major bleeding) occurring during treatment. A clinical events committee will adjudicate all outcomes.

Ethics and dissemination
The study protocol has been approved by the Nihon University Itabashi Hospital, Clinical Research Ethics Committee and all local institutional ethics committees of the participating hospitals. Findings of the study will be presented in scientific sessions and will be published in peer-reviewed journals.

Trial registration number

NCT03091621
Origen social, competencias lingüísticas y patrones de publicación científica en Argentina, Brasil y Chile
Authors: Almeida Ana Maria , Baranger Denis , Piovani Juan Ignacio 
Published: May 2023

En este artículo se analizan las condiciones de adquisición de competencia lingüística en lenguainglesa y el uso de idiomas extranjeros en las publicaciones de investigadores de Argentina, Brasil y Chile. El análisis se basa en los resultados de una encuesta cross-national realizada a muestras de investigadores integrados al núcleo central del sistema científico de cada país. En relación con el foco principal del artículo, se abordan las modalidades de adquisición de la competencia lingüística y su relación con factores sociodemográficos, como el origen social, y con la trayectoriaformativa. Por otra parte, se analiza la relación entre las competencias lingüísticas y la publicación científica, y se explora el lugar de las disciplinas en el uso de idiomas extranjeros. Los resultados ponen en evidencia que existe una asociación entre el origen social, la trayectoria formativa, lasmodalidades de adquisición de competencias en inglés y el nivel de dichas competencias. Sin embargo, e independientemente de su dominio de la lengua, la mayoría de los investigadores de los tres países publica en inglés y, en todo caso, su nivel de competencia tiene incidencia en las estrategias de escritura (autónomas, colaborativas o por traducción profesional). En términoscomparativos, los científicos brasileños son los que más publican en inglés, aunque en el caso chileno la menor proporción de publicaciones en esta lengua podría deberse al mayor peso que tienen en su muestra los investigadores de ciencias sociales y humanas, toda vez que, en estasdisciplinas, al menos en América Latina, el inglés no ha adquirido un estatus de lingua franca equivalente al de las ciencias naturales.
Duelos e intelectuais no Brasil (1886-1892)
Authors: Severo Marconi 
Published: May 2023

Durante os anos finais do Império e o início da República, o duelo foi vivenciado como uma moda por um pequeno grupo de homens cultos e socialmente bem-colocados. A sua análise permite apreender as relações estabelecidas entre as classes sociais e o modo como recursos alternativos à esfera estatal, sobretudo no que se refere ao uso da violência privada, podiam ser mobilizados para resolver pendências pessoais. Embora potencialmente letal, o duelo serviu menos para reparar a honra supostamente ferida do que como um meio empregado para aumentar e assegurar a coesão do grupo mediante sua distinção social.
Circulación situada e idiomas de publicación de las élites académicas del Cono Sur
Authors: Beigel Fernanda , Bringel Breno 
Published: May 2023

Este artículo analiza la relación entre las autopercepciones de los investigadores acerca del valor de la publicación en inglés y la diversidad de prácticas de circulación que se observan en su trayectoria completa de publicaciones. Para ello, nos basamos metodológicamente en una encuesta trinacional realizada con la élite académica de Argentina, Brasil y Chile y en la observación empírica de una muestra de currículums de investigadores de estos tres países. La contribución del texto apunta en una doble dirección: en términos conceptuales, proponemos el concepto de “circulación situada” como alternativa a perspectivas lineales y tradicionales de la internacionalización; en el terreno empírico, mostramos cómo la bibliodiversidad en las trayectorias académicas y la multi-escalaridad de la circulación de esos académicos proyecta una mirada compleja en los tres casos. Como consecuencia, los hallazgos nos permiten ir más allá de las visiones habituales sobre el inglés como idioma de publicación y avanzar en el debate sobre el dinamismo del proceso de circulación y sus anclajes socio-institucionales.
Jovens ciganos no ensino médio em Portugal: fatores-chave para a continuidade e o sucesso escolar
Authors: Mendes Maria Manuela , Magano Olga , Pinheiro Sara , Mourão Susana 
Published: May 2023

Apesar de em Portugal existirem políticas públicas de combate às desigualdades, incluindo as escolares, a origem socioeconômica, o gênero e a pertença étnica dos estudantes continuam a ter um impacto incontornável nos percursos escolares. Os ciganos são dos mais afetados por essas desigualdades, reveladas pelas ainda salientes taxas de abandono escolar precoce e por retenções e insucesso escolar. Tendo por base os resultados derivados de entrevistas semidiretivas, o objetivo do artigo consiste em compreender os fatores-chave determinantes nas trajetórias de continuidade escolar dos ciganos no ensino médio. Os resultados revelam jovens tendencialmente mais escolarizados que as gerações anteriores, evidenciando-se a importância do contexto familiar, mas também a agencialidade e a resiliência.
Mobilidade e cidade: epistemologia e pesquisa
Authors: Souza Candice Vidal e 
Published: May 2023

O artigo explora a mobilidade, tratando das características epistemológicas e das implicações metodológicas de algumas novidades que o chamado mobilities turn tem trazido para a pesquisa social, notadamente para a investigação de processos urbanos. Reflete-se sobre a dimensão inovadora dos estudos atuais em mobilidades, os quais se expandem para além da sociologia e da antropologia e se situam sobretudo na geografia. Em seguida, é considerada a definição do social e de espaço-tempo epistemologicamente compatível como a virada da mobilidade. Por fim, as consequências dessas posições para a pesquisa em cidades são exploradas para se concluir que elementos da tradição de pesquisas urbanas convergem para esta cena do presente, revelando afinidades epistemológicas e conceituais com modos contemporâneos de pensar a cidade.
Lei do desmanche, PCC e mercados
Authors: Feltran Gabriel , Rocha Rafael , Maldonado Janaina , Zambon Gregório , Gobbi Fernanda de 
Published: May 2023

No estado de São Paulo, as notificações de roubos e furtos de veículos cresceram entre 2003 e 2014. Desde então, esse tipo de crime tem diminuído. O que explicaria essa oscilação? Combinando experiências etnográficas e dados quantitativos, o artigo propõe um quadro analítico composto por três hipóteses explicativas: (i) a implementação da “Lei do Desmanche”; (ii) as transformações nas dinâmicas do Primeiro Comando da Capital e (iii) as mudanças econômicas associadas à indústria automobilística. Nossos resultados sugerem que a implementação da “Lei do Desmanche”, regulando o mercado ilegal de autopeças, teve efeitos decisivos na diminuição da subtração veicular. As demais hipóteses sugerem efeitos acessórios que também merecem atenção.
From the scrapyard to the ELV center: when the old car becomes a global resource
Authors: Jacquot Sébastien , Morelle Marie 
Published: May 2023

This article focuses on the structuring of the end-of-life vehicle processing and recycling (ELV processing) sector in France. First, it traces the emergence and the structuring of scrapyards. It then analyses the gradual introduction of regulations aimed at curbing informality in the sector, and at promoting the development of a circular economy. Scrapyards, which have now become “ELV recycling centers”, are gradually absorbed into a capitalist and highly technical apparatus, in the name of a “green economy”. The article proposes to discuss the value of end-of-life vehicles, which are often considered as a source of pollution and waste, but can also be a source of parts and materials, at the intersection of national and transnational formal and informal circulations.