bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding Dangerous Waves—Review of Methods to Obtain Wave Impact Design Loads for Marine Structures
Authors: van Essen Sanne , Seyffert Harleigh 
Published: February 2023

AbstractGreen water and slamming wave impacts can lead to severe damage or operability issues for marine structures. It is therefore essential to consider their probability and loads in design. This is difficult, as impacts are both hydrodynamically complex and relatively rare. The complexity requires high-fidelity modeling (experiments or CFD), whereas a statistically sound analysis of rare events requires long durations. High-fidelity tools are too demanding to run a Monte–Carlo simulation; low-fidelity tools do not include sufficient physical details. The use of extreme value theory and/or multi-fidelity modeling is therefore required. The present paper reviews the state-of-the-art methods to find wave impact design loads, which include response-conditioning methods, screening methods, and adaptive sampling methods. Their benefits and shortcomings are discussed, as well as challenges for the wave impact problem. One challenge is the role of wave non-linearity. Another is the validation of the different methods; it is hard to obtain long-duration high-fidelity wave impact data.
Correlations Describing Laminar Hydrodynamic Development in a Circular Pipe
Authors: Kaya Kenan , Özcan Oktay 
Published: February 2023

AbstractComputational fluid dynamics (CFD) is employed to study incompressible and steady laminar flow in the hydrodynamic entrance region of circular pipes for a wide range of Reynolds numbers. Dimensionless analytic expressions for streamwise variations of the centerline velocity, skin friction coefficient, and pressure drop are derived by applying a two-stage nonlinear regression analysis to computational solutions of the Navier–Stokes equations for various Reynolds numbers between 1 and 2000. Similar expressions are also presented for the correction factors for the momentum and kinetic energy fluxes. First, the correlation parameters for a flow variable are obtained for each Reynolds number considered. Subsequently, a second nonlinear regression analysis is conducted to obtain another set of equations for the variation of fitting parameters with the Reynolds number. Constant parameter correlations are also given for the Reynolds number range between 200 and 2000, which are less accurate than the expressions containing Reynolds number-dependent terms. The correlations presented here are also valid for flows with heat transfer, under the assumptions of constant property and zero buoyancy.
Martian soil as revealed by ground-penetrating radar at the Tianwen-1 landing site
Authors: Chen Ruonan , Zhang Ling , Xu Yi , Liu Renrui , Bugiolacchi Roberto , Zhang Xiaoping , Chen Lu , Zeng Zhaofa , Liu Cai 
Published: February 2023

AbstractMuch of the Martian surface is covered by a weathering layer (regolith or soil) produced by long-term surface processes such as impact gardening, eolian erosion, water weathering, and glacial modifications. China’s first Martian mission, Tianwen-1, employed the Mars Rover Penetrating Radar (RoPeR) to unveil the detailed structure of the regolith layer and assess its loss tangent. The RoPeR radargram revealed the local regolith layer to be highly heterogeneous and geologically complex and characterized by structures that resemble partial or complete crater walls and near-surface impact lenses at a very shallow depth. However, comparable radar data from the Lunar far side are rather uniform, despite the two surfaces being geologically contemporary. The close-to-surface crater presented in this study shows no detectable surface expression, which suggests an accelerated occultation rate for small craters on the surface of Mars as compared to the rate on the Moon. This is probably due to the relentless eolian processes on the Martian surface that led to the burial of the crater and thus shielded it from further erosion. The high loss tangent indicates that the regolith at the Tianwen-1 landing site is not dominated by water ice.
Levels of immunoglobulin isotypes in serum and respiratory samples of patients with chronic obstructive pulmonary disease: protocol for a systematic review and meta-analysis
Authors: Unninayar Dana , Shea Beverley , Cameron D William , Cowan Juthaporn 
Published: February 2023

IntroductionChronic obstructive pulmonary disease (COPD) is an inflammatory respiratory disorder characterised by the progressive worsening of lung function. Acute exacerbation of COPD (AECOPD) is a leading contributor to patient morbidity, mortality and hospitalisations. The clinical significance of immunoglobulin (Ig) levels in COPD patients is not well established and is in need of further investigation.Methods and analysisWe will conduct a systematic review to describe levels of different Ig isotypes (IgG, IgA and IgM) in various samples (serum, sputum and bronchoalveolar lavage) of patients with COPD. IgE levels in COPD patients have been researched and reviewed extensively and hence will be excluded from this review. IgD levels will also be excluded from the review as there is a paucity of data on IgD levels in COPD patients. The primary outcome of interest in this systematic review is assessing Ig isotype levels in patients with COPD. Secondary outcomes that will be assessed include the differences between Ig isotype levels in COPD patients compared with healthy controls, as well as the relationships between Ig isotype levels and key clinical variables, including COPD severity, incidence of AECOPD and AECOPD severity. Embase and Ovid MEDLINE will be used to search for non-randomised studies published from 1946 to October 2022 that report our prespecified primary and secondary outcomes. As per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol, retrieved studies will undergo a two-phase screening process conducted by two independent reviewers. Prespecified primary and secondary outcomes will be extracted from eligible studies, and descriptive statistics will be used to analyse extracted outcomes. The risk of bias will be assessed using the Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) tool.Ethics and disseminationEthics approval is not required as this is a protocol for a systematic review and meta-analysis. Findings will be disseminated through peer-reviewed publications and other formats including conference presentations.PROSPERO registration numberCRD42020192220.
Association between obesity and 1-year mortality in septic patients: a retrospective cohort study
Authors: Zhang Li , Fang Lingna , Lihua Hang , Li Chong 
Published: February 2023

ObjectiveSepsis is a major contributor of intensive care units (ICUs) patient mortality. Prior investigations claimed that obesity enhances overall survival (OS) of septic patients. However, the reported results were inconsistent. This study examined the association between obesity and the 1-year mortality of septic patients.DesignA retrospective cohort study.SettingThe Medical Information Mart for Intensive Care III database.Participants3145 septic patients were separated into three distinct cohorts, based on their WHO body mass index (BMI) status.OutcomesOur primary endpoint was the 1-year mortality from the date of ICU hospitalization.Result1334 (42.4%) died within 1 year. The 1-year mortality rate was low in obese patients (38.8%), compared with normal (46.9%) and overweight (42.1%) patients. Crude assessment revealed that obese patients experienced reduced 1-year mortality, relative to normal weight patients (HR 0.79, 95% CI 0.69 to 0.9, p<0.001). However, once adjusted for baseline variables and comorbidities, no correlation was found between obesity and the 1-year mortality (HR 0.93, 95% CI 0.81 to 1.06, p=0.28) of septic patients. There was an association among diabetic (HR 0.72, 95% CI 0.56 to 0.93, p=0.012) and hypertensive (HR 0.73, 95% CI 0.58 to 0.92, p=0.008) patients, and among males (HR 0.71, 95% CI 0.59 to 0.86, p<0.001), with obese individuals experiencing the lowest mortality rate. Given these evidences, the interactions between BMI and mortality in diabetic (p=0.031) and hypertensive (p=0.035) patients were significant.ConclusionIn our study, obese diabetic and hypertensive patients associated to less sepsis-related mortality risk, compared with normal weight patients. Further researches were need to validated.
Protocol for the derivation and external validation of a 30-day postoperative pulmonary complications (PPCs) risk prediction model for elderly patients undergoing thoracic surgery: a cohort study in southern China
Authors: Wei Wei , Zheng Xi , Zhou Chao Wei , Zhang Anyu , Zhou Ming , Yao HuaYong , Jiang Tao 
Published: February 2023

IntroductionPostoperative pulmonary complications (PPCs) occur after up to 60% of non-cardiac thoracic surgery (NCTS), especially for multimorbid elderly patients. Nevertheless, current risk prediction models for PPCs have major limitations regarding derivation and validation, and do not account for the specific risks of NCTS patients. Well-founded and externally validated models specific to elderly NCTS patients are warranted to inform consent and treatment decisions.Methods and analysisWe will develop, internally and externally validate a multivariable risk model to predict 30-day PPCs in elderly NCTS patients. Our cohort will be generated in three study sites in southern China with a target population of approximately 1400 between October 2021 and December 2023. Candidate predictors have been selected based on published data, clinical expertise and epidemiological knowledge. Our model will be derived using the combination of multivariable logistic regression and bootstrapping technique to lessen predictors. The final model will be internally validated using bootstrapping validation technique and externally validated using data from different study sites. A parsimonious risk score will then be developed on the basis of beta estimates derived from the logistic model. Model performance will be evaluated using area under the receiver operating characteristic curve, max-rescaled Brier score and calibration slope. In exploratory analysis, we will also assess the net benefit of Probability of PPCs Associated with THoracic surgery in elderly patients score in the complete cohort using decision curve analysis.Ethics and disseminationEthical approval has been obtained from the Institutional Review Board of the Affiliated Cancer Hospital and Institute of Guangzhou Medical University, the Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and the University of Hongkong—Shenzhen Hospital, respectively. The final risk prediction model will be published in an appropriate journal and further disseminated as an online calculator or nomogram for clinical application. Approved and anonymised data will be shared.Trial registration numberChiCTR2100051170.
Cardiorespiratory Optimisation By Arteriovenous fistula Ligation after renal Transplantation (COBALT): study protocol for a multicentre randomised interventional feasibility trial
Authors: Surendrakumar Veena , Aitken Emma , Mark Patrick , Motallebzadeh Reza , Hunter James , Amer Aimen , Summers Dominic , Rennie Kirsten , Rooshenas Leila , Garbi Madalina , Sylvester Karl , Hudson Cara , Banks Jennifer , Sidders Anna , Norton Andrew , Slater Matthew , Bartlett Matthew , Knight Simon , Pettigrew Gavin 
Published: February 2023

IntroductionCardiovascular events are a major cause of mortality following successful kidney transplantation.Arteriovenous fistulas (AVFs) are considered the best option for haemodialysis, but may contribute to this excess mortality because they promote adverse cardiac remodelling and ventricular hypertrophy. This raises the question whether recipients with a well-functioning kidney transplant should undergo elective AVF ligation.Methods and analysisThe COBALT feasibility study is a multicentre interventional randomised controlled trial (RCT) that will randomise renal transplant patients with stable graft function and a working AVF on a 1:1 basis to standard care (continued conservative management) or to AVF ligation. All patients will perform cardiopulmonary exercise testing (CPET) on recruitment and 6 months later. Daily functioning and quality of life will be additionally assessed by questionnaire completion and objective measure of physical activity. The primary outcome—the proportion of approached patients who complete the study (incorporating rates of consent, receipt of allocated intervention and completion of both CPETs without withdrawal)—will determine progression to a full-scale RCT. Design of the proposed RCT will be informed by an embedded qualitative assessment of participant and healthcare professional involvement.Ethics and disseminationThis study has been approved by the East Midlands—Derby Research Ethics Committee (22/EM/0002) and the Health Research Authority. The results of this work will be disseminated academically through presentation at national and international renal meetings and via open access, peer-reviewed outputs. Existing networks of renal patient groups will also be used to disseminate the study findings to other key stakeholders.Trial registration numberISRCTN49033491.
Low-dose RaDiation therapy for patients with KNee osteoArthritis (LoRD-KNeA): a protocol for a sham-controlled randomised trial
Authors: Kim Byoung Hyuck , Shin Kichul , Kim Min Jung , Kim Hak Jae , Ro Du Hyun , Wang Joon Ho , Lee Dae-Hee , Kim Dong Hyun , Sun Jiyu , Lee Ji Hyun , Kim Ji Young , Hong Eun-Hee , Cho Seong-Jun , Han Hyuk-Soo , Park Won 
Published: February 2023

IntroductionLow-dose radiation therapy (LDRT) for osteoarthritis (OA) has been performed for several decades. However, supporting evidence from randomised studies using modern methodologies is lacking, and a recently published randomised study failed to show the significant benefit of LDRT. The presented trial aims to evaluate the efficacy and safety of LDRT for patients with knee OA.Methods and analysisThis prospective, multicentre, randomised trial will be conducted in the Republic of Korea. A total of 114 participants will be randomly assigned (1:1:1) to receive sham irradiation, 0.3 Gy/6 fractions of LDRT or 3 Gy/6 fractions of LDRT. Key inclusion criteria are primary knee OA with Kellgren-Lawrence grade 2–3 and visual analogue scale 50–90 when walking at the baseline. The primary endpoint is the rate of responders at 4 months after LDRT according to the OARSI-OMERACT criteria. Concomitant use of analgesics is prohibited until the primary efficacy evaluation is scheduled.Ethics and disseminationCurrently, approval from the Ministry of Food and Drug Safety of the Republic of Korea and the institutional review board of each participating hospital has been obtained. Patient enrolment began in October 2022 and is ongoing at three participating sites. The results will be disseminated to academic audiences and the public via publication in an international peer-reviewed journal and presentation at conferences. This trial will provide valuable information on the safety and efficacy of LDRT for patients with knee OA.Trial registration numberNCT05562271.
Prospective study of retention in opioid agonist treatment and contact with emergency healthcare following release from prisons in Victoria, Australia
Authors: Curtis Michael , Wilkinson Anna L , Dietze Paul , Stewart Ashleigh Cara , Kinner Stuart A , Cossar Reece David , Nehme Emily , Aitken Campbell , Walker Shelley , Butler Tony , Winter Rebecca J , Smith Karen , Stoove Mark 
Published: February 2023

BackgroundPeople recently released from prison engage with emergency healthcare at greater rates than the general population. While retention in opioid agonist treatment (OAT) is associated with substantial reductions in the risk of opioid-related mortality postrelease, it is unknown how OAT affects contact with emergency healthcare. In a cohort of men who injected drugs regularly prior to imprisonment, we described rates of contact with ambulance services and EDs, and their associations with use of OAT, in the 3 months after release from prison.MethodsSelf-report data from a prospective observational cohort of men who regularly injected drugs before a period of sentenced imprisonment, recruited between September 2014 and May 2016, were linked to state-wide ambulance and ED records over a 3-month postrelease period in Victoria, Australia. We used generalised linear models to estimate associations between OAT use (none/interrupted/retained) and contact with ambulance and EDs postrelease, adjusted for other covariates.ResultsAmong 265 participants, we observed 77 ambulance contacts and 123 ED contacts over a median of 98 days of observation (IQR 87–125 days). Participants who were retained in OAT between prison release and scheduled 3-month postrelease follow-up interviews had lower rates of contact with ambulance (adjusted incidence rate ratio (AIRR) 0.33, 95% CI 0.14 to 0.76) and ED (AIRR 0.43, 95% CI 0.22 to 0.83), compared with participants with no OAT use postrelease. Participants with interrupted OAT use did not differ from those with no OAT use in rates of contact with ambulance or ED.ConclusionWe found lower rates of contact with emergency healthcare after release among people retained in OAT, but not among people reporting interrupted OAT use, underscoring the benefits of postrelease OAT retention. Strategies to improve accessibility and support OAT retention after leaving prison are important for men who inject drugs.
Prediction of short-term atrial fibrillation risk using primary care electronic health records
Authors: Nadarajah Ramesh , Wu Jianhua , Hogg David , Raveendra Keerthenan , Nakao Yoko M , Nakao Kazuhiro , Arbel Ronen , Haim Moti , Zahger Doron , Parry John , Bates Chris , Cowan Campbel , Gale Chris P 
Published: February 2023

ObjectiveAtrial fibrillation (AF) screening by age achieves a low yield and misses younger individuals. We aimed to develop an algorithm in nationwide routinely collected primary care data to predict the risk of incident AF within 6 months (Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF)).MethodsWe used primary care electronic health record data from individuals aged ≥30 years without known AF in the UK Clinical Practice Research Datalink-GOLD dataset between 2 January 1998 and 30 November 2018, randomly divided into training (80%) and testing (20%) datasets. We trained a random forest classifier using age, sex, ethnicity and comorbidities. Prediction performance was evaluated in the testing dataset with internal bootstrap validation with 200 samples, and compared against the CHA2DS2-VASc (Congestive heart failure, Hypertension, Age >75 (2 points), Stroke/transient ischaemic attack/thromboembolism (2 points), Vascular disease, Age 65–74, Sex category) and C2HEST (Coronary artery disease/Chronic obstructive pulmonary disease (1 point each), Hypertension, Elderly (age ≥75, 2 points), Systolic heart failure, Thyroid disease (hyperthyroidism)) scores. Cox proportional hazard models with competing risk of death were fit for incident longer-term AF between higher and lower FIND-AF-predicted risk.ResultsOf 2 081 139 individuals in the cohort, 7386 developed AF within 6 months. FIND-AF could be applied to all records. In the testing dataset (n=416 228), discrimination performance was strongest for FIND-AF (area under the receiver operating characteristic curve 0.824, 95% CI 0.814 to 0.834) compared with CHA2DS2-VASc (0.784, 0.773 to 0.794) and C2HEST (0.757, 0.744 to 0.770), and robust by sex and ethnic group. The higher predicted risk cohort, compared with lower predicted risk, had a 20-fold higher 6-month incidence rate for AF and higher long-term hazard for AF (HR 8.75, 95% CI 8.44 to 9.06).ConclusionsFIND-AF, a machine learning algorithm applicable at scale in routinely collected primary care data, identifies people at higher risk of short-term AF.
Neoadjuvant sintilimab and chemotherapy in patients with potentially resectable esophageal squamous cell carcinoma (KEEP-G 03): an open-label, single-arm, phase 2 trial
Authors: Chen Xiaofeng , Xu Xiang , Wang Danping , Liu Jinyuan , Sun Jing , Lu Mingjie , Wang Rui , Hui Bingqing , Li Xiaofei , Zhou Chenchen , Wang Min , Qiu Tianzhu , Cui Shiyun , Sun Nana , Li Yang , Wang Fufeng , Liu Cuicui , Shao Yang , Luo Jinhua , Gu Yanhong 
Published: February 2023

BackgroundThe standard neoadjuvant treatments in patients with esophageal squamous cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed in China.MethodsThis was an open-label, single-arm, phase 2 trial. Patients with potentially resectable ESCC (cT1b-3, Nany, M0 or T4a, N0-1, or M0) received preoperative intravenous sintilimab plus triplet chemotherapy (liposomal paclitaxel, cisplatin, and S-1) every 3 weeks for two cycles. The primary endpoints were safety and surgical feasibility; the secondary endpoint was major pathological response (MPR) rate. Genomic biomarkers (genetic mutations, tumor mutational burden (TMB), circulating tumor DNA status and immune microenvironment) in baseline tumor samples were investigated.ResultsAll 30 patients completed two cycles of neoadjuvant treatment and underwent surgical resection. Grade 3–4 treatment-related adverse events (TRAEs) occurred in 36.7% (11/30) of patients. The most frequent TRAEs were decreased white cell count (76.7%), anemia (76.7%), and decreased neutrophil count (73.3%). All TRAEs were hematological toxicities; none caused ≥30 days surgical delay. The MPR and pathological complete response (pCR) rates were 50.0% (15/30; 95% CI 33.2 to 66.9) and 20.0% (6/30; 95% CI 9.5 to 37.3), respectively. Patients with higher TMB and more clonal mutations were more likely to respond. ERBB2 alterations and ctDNA high-releaser status have a negative correlation with neoadjuvant ICI response. No significant difference was observed between therapeutic response and tumor immune microenvironment.ConclusionsNeoadjuvant sintilimab plus platinum-based triplet chemotherapy appeared safe and feasible, did not delay surgery and induced a pCR rate of 20.0% in patients with potentially resectable ESCC.Trial registration numberNCT03946969.