bluuebunny/crossref_metadata_2025_split huggingface dataset:
North Atlantic chlorophyll blooming enhances terrestrial primary productivity over Europe
Authors: Yang Young-Min , Park Jae-Heung , Park Jong-Yeon , An Soon-Il , Yeh Sang-Wook , Kwon Eun Young , Lee June-Yi , Li Tim 
Published: March 2023

Abstract
The global carbon cycle is strongly influenced by terrestrial productivity and ocean plankton concentration in the upper ocean1-4, with some carbon being transported from land to the ocean by chemical processes 5-9 and possibly returned to the atmosphere. High-latitude Ocean plankton may contribute to rapid surface warming, which could remotely affect terrestrial ecosystems by modifying adjacent continental climate conditions. However, this possible impact of ocean chlorophyll concentration on terrestrial activities and carbon sinks remains unclear.
Here, we found that high-latitude North Atlantic chlorophyll blooming could have a positive impact on terrestrial productivity and agriculture over Europe, potentially contributing to increased carbon sinks. A stable supply of nutrients in high latitudes allows for chlorophyll blooming, which traps more incoming shortwave radiation and contributes to surface warming. This, in turn, leads to increased precipitation over Europe through atmospheric teleconnection, accelerating terrestrial productivity (15-20% of the gross primary productivity), crop yields, and carbon sink during the growing season. Model results suggest that chlorophyll concentrations over the North Atlantic ocean significantly impact terrestrial activities in Europe, and an increase in future chlorophyll blooming events could enhance the terrestrial ecosystem as a carbon sink, contributing to negative carbon-climate feedback. Our results highlight the positive interaction between the marine and terrestrial ecosystems and the importance of considering these interactions in future assessments.
Precision spectroscopy and laser cooling scheme of a radium-containing molecule
Authors: Udrescu Silviu-Marian , Wilkins Shane , Breier Alexander , Ruiz Ronald Fernando Garcia , Athanasakis-Kaklamanakis Michail , Au Mia , Belošević Ivana , Berger Robert , Bissell Mark , Chrysalidis Katerina , Cocolios Thomas , Groote Ruben , Dorne Anais , Flanagan Kieran , Franchoo Serge , Gaul Konstantin , Geldhof Sarina , Giesen Thomas , Hanstorp Dag , Heinke Reinhard , Koszorús Agota , Kujanpää Sonja , Lalanne Louis , Neyens Gerda , Nichols Miranda , Perrett Holly , Reilly Jordan , Rothe Sebastian , Borne Bram van den , Wang Quanjun , Wessolek Julius , Yang Xiaofei , Zülch Carsten 
Published: March 2023

Abstract
Molecules containing heavy, radioactive nuclei are predicted to be extremely sensitive to violations of the fundamental symmetries of nature. Radium monofluoride molecules are of particular interest, as the nuclear octupole deformation of certain radium isotopes massively boosts their sensitivity to symmetry-violating nuclear properties. Moreover, they are predicted to be laser coolable, opening up a wide range of opportunities for precision studies. Here, we present measurements of the rovibronic structure of these molecules, which allow an unambiguous determination of their laser cooling scheme. We demonstrate an improvement in resolution of more than two orders of magnitude compared to previous studies. Our developments allowed measurements of minuscule amounts of hot molecules, with only a few hundred per second produced in a particular rotational state. The combined precision and sensitivity achieved in this work offer new opportunities for studies of radioactive molecules of interest in fundamental physics, chemistry and astrophysics.
Clinical characteristics of postoperative cognitive dysfunction after local balloon compression for trigeminal neuralgia: a retrospective study
Authors: lin LI , yonggang Luo , min Liu , xue He 
Published: March 2023

Abstract
Purpose
To identify the high-risk population of trigeminal neuralgia (TN) with postoperative cognitive dysfunction, reduce the consequent long-term postoperative complications, and improve the postoperative quality of life.
Methods
A retrospective study was conducted among 94 TN patients that underwent percutaneous balloon compression in the Affiliated Huai 'an First People's Hospital of Nanjing Medical University from 2017 to 2022. Patients were divided according to the post- Mini-Mental State Examimation (MMSE) scores (postoperative cognitive dysfunction and postoperative cognitive function normal groups). General information, past medical history, laboratory examination, treatment methods, self rating anxiety scale (SAS) score, visual analog scale (VAS) score and MMSE score were collected.
Results
Total 21 patients developed postoperative cognitive impairment, of which 16 were transient, and 3 were prolonged. Postoperative cognitive impairment prolonged the hospital stay (p&lt; 0.001). Advanced age (p = 0.028), high preoperative SAS score (p < 0.001), and prolonged anesthesia duration (p < 0.032) were independent risk factors for surgical patients of TN. Three patients in the postoperative cognitive dysfunction group showed brain swelling and extensive white matter degeneration in the frontal and parietal lobes. Eight patients were treated with hyperbaric oxygen (HBO), following which, the MMSE score was significantly higher (p < 0.05) than that in the group without HBO, with no long-term complications. Preoperative SAS score was negatively correlated with the postoperative MMSE score (R = 0.3541, p < 0.001).
Conclusion
Postoperative cognitive dysfunction prolongs hospital stay in patients with TN. Functional magnetic resonance imaging can reflect brain tissue damage, and HBO therapy helps in postoperative cognitive function recovery.
Assessing spatio temporal changes in landcover using geospatial and remote sensing techniques in the fringes of Southern Chennai
Authors: R Narayani A , R Nagalakshmi 
Published: March 2023

Abstract

Peri-urban areas are transitional zones on a city's outer boundaries or edges. These regions have immense growth potential and are developing at a rapid speed. Hence it is necessary to observe the land use land cover and constant changes to understand the dynamics of these transformations. The study area selected for this study is towards the Southern fringe of Chennai, Tamil Nādu, India. Multi-spectral satellite imagery from Landsat 5 and 8 is analysed for this study. The primary intent of the study is to assess the change in the three landcover classes, namely water, land, and vegetation, over a 30-year study period between 1991-2021. The peri-urban regions majorly are arable land. Hence NDVI is considered a suitable index to monitor the land cover changes in the area of interest. The spatiotemporal analysis indicates an increase of 19.43% in land /barren areas towards the Northern parts near the study area and along the transit and industrial corridors. No significant changes are observed in the areas of vegetation that could be attributed to efforts taken to conserve reserve forests and increase green zones in newer developments. A steep depletion of 46.86% of water bodies observed in the region also corresponds to water scarcity problems. Accuracy was assessed using ground-truthing methods, computing the confusion matrix and Kappa coefficient. NDVI is used efficiently in the land cover classification but does not indicate the difference between built-up areas and barren land. Change detection map prepared using ARCGIS, indicates the areas that have been converted to other landcover over a period of 30years. The study reveals an urgent need bring in policy decisions to conserve waterbodies in the initial stages of urban planning for sustainable developments in the fringe areas.
Sodium-Glucose Cotransporter-2 Inhibitors for Hyperglycemia in Phosphoinositide 3-kinase Pathway Inhibition
Authors: Weintraub Michael A , Liu Dazhi , DeMatteo Raymond , Goncalves Marcus DaSilva , Flory James 
Published: March 2023

Abstract
Purpose
Phosphoinositide 3-kinase (PI3K) inhibition is used for the treatment of certain cancers, but can cause profound hyperglycemia and insulin resistance, for which sodium-glucose cotransporter-2 (SGLT2) inhibitors have been proposed as a preferred therapy. The objective of this research is to assess the effectiveness and safety of SGLT2 inhibitors for hyperglycemia in PI3K inhibition.
Methods
We conducted a single-center retrospective review of adults initiating the PI3k inhibitor alpelisib. Exposure to different antidiabetic drugs and adverse events including diabetic ketoacidosis (DKA) were assessed through chart review. Plasma and point-of-care blood glucoses were extracted from the electronic medical record. Change in serum glucose and the rate of DKA on SGLT2 inhibitor versus other antidiabetic drugs were examined as co-primary outcomes.
Results
We identified 103 patients meeting eligibility criteria with median follow-up of 85 days after starting alpelisib. When SGLT2 inhibitors were used to treat hyperglycemia, they were associated with a decrease in mean random glucose by -54 mg/dL (95% CI -99 to -8) in adjusted linear modeling. Five cases of DKA were identified, two occurring in patients on alpelisib plus SGLT2 inhibitor. Estimated incidence of DKA was: alpelisib plus SGLT2 inhibitor, 24 DKA cases per 100 patient-years (95% CI 6, 80); alpelisib with non-SGLT2 inhibitor antidiabetic drugs, 7 (95% CI 0.1, 34); alpelisib only, 4 (95% CI 0.1, 21).
Conclusions
SGLT2 inhibitors are effective treatments for hyperglycemia in the setting of PI3K inhibition, but given possible adverse events, SGLT2 inhibitors should be used with caution.
Remote assessment of sustained attention: the reliability of the CCPT-V self-administered at home using local installation Vs. lab setting.
Authors: Dankner Yarden , Yuval-Greenberg Shlomit , Shalev Lilach 
Published: March 2023

Abstract

Sustained attention is commonly assessed using different versions of a continuous performance task (CPT), by calculating accuracy rates and reaction time (RT) based measures. Therefore, a valid assessment of sustained attention requires precise recording of RTs. Online tasks are especially prone to RT measuring errors, due to numerous differences in participants’ computers and task compliance. This paper presents a comparison between performance measures, reliability, and time-on-task effect of the Conjunctive-CPT preformed in a controlled lab setting vs. a home setting with the local installation of the task. Two groups of 51 neurotypical adults performed the task either in a lab or in their homes. We observed similar accuracy rates and RT measures in both groups. The split half reliability of measures was slightly attenuated in the home group, yet sufficient for studying individual differences. Results suggest remote administration with local installation is a reliable method when = assessing sustained attention and exploring individual differences through RT measurements. The findings have important implications for both research and clinical uses in circumstances in which in-person assessment is complicated or impossible.
Thermoresponsive, dually cross-linked elastin-like-polypeptide (ELP) micelle hydrogel with recovery properties
Authors: Choi Jongsoo , Ryu Moon-Chul , Kim Jae Jung , Choi Soo-Hyung , Won Jong-In 
Published: March 2023

Abstract
Recently, thermoresponsive protein-based hydrogels were widely used due to their high potential in biomedical fields. Elastin-like polypeptides (ELPs) are one of the proteins that show lower critical solution temperature (LCST) behavior, resulting in self-assembly above critical micellular temperature (CMT). Here, we utilized ABC-type blocky ELPs to form hydrogels by intoducing cross-linking sites, resulting in good mechanical properties. The hydrogels showed temperature-dependent viscoelasticity due to their structure change. Also, the recovery process of ELP-based hydrogels after large deformation is significantly dependent on the types of cross-linking (i.e., ionic, covalent, or ionic-covalent hybrid).
Identification of Risk Factors for Disabilities in Children Following Clinically Important Traumatic Brain Injury: a prospective cohort study
Authors: KADRI Hassan , Daood Huda , Hussain Barah , Makkieh Rustom , Marwa Ghassan 
Published: March 2023

Abstract
Background: Head injury is a common occurrence in children and is one of the leading causes of death and disability in this age group. Accurately predicting the outcome of children with head injuries is critical for appropriate treatment and management of these patients.
Purpose: The aim of this study was to determine the risk factors that can help predict the outcome of children who were admitted after a clinically important head injury.
Methods: We prospectively analysed the data of 65 patients under the age of 13 years who were admitted to our hospital after a clinically important head traumatic brain injury (TBI). We statistically analysed various parameters such as age, gender, mechanism of trauma, consciousness level, convulsion, vomiting, radiological investigation, duration of hospitalization, and the need for mechanical ventilation.
Results: Our study showed that some parameters gave significant predictive value for the final outcome, such as the mechanism of trauma, consciousness level, convulsion, radiological investigation, duration of hospitalization, and the need for mechanical ventilation. However, age, gender, and vomiting had no significant predictive value.
Conclusion: Our findings suggest that accurate prediction of the outcome of children with head injuries is possible by considering certain risk factors. This can aid in appropriate treatment and management of these patients, which is critical for their recovery and rehabilitation. Further studies with larger sample sizes are needed to confirm our findings.
A Comprehensive Integrated Analysis of DDX3X Expression, Prognostic Value and Potential Implications for Pan-Cancer Immunity
Authors: Pang Xi , Ji Jingmin , Cai Xinyu , Ruan Shanming , Jin Huimin 
Published: March 2023

Abstract
Background: DEAD-box RNA Helicases (DDX3X) is a category of protein that imitate tumourigenesis, invasion, and immune escape by competing in RNA absorption and binding proteins, but allure system debris is expected purified.
Methods: In our research, Cancer Genome Atlas and the Genotype-Tissue Expression Database were discovered to decide the changed verbalization of DDX3X in pan-carcinoma growth, and TIMER (Tumor Immune Estimation Resource) was used to discover the verbalization of DDX3X and the level of invulnerable combination. It’s rooted that DDX3X verbalization was well compared accompanying an assortment of diseased invulnerable genes, invulnerable container combination and cut, carcinoma mutational load, and DNA microsatellite inconstancy. DDX3X keep thus be secondhand as a prognostically appropriate immunotherapeutic goal for malignancy forecast.
Effects of Open Skies Policy in the Dominican Republic: A Quasi-Experimental Analysis
Authors: Café Eduardo , Gomes Victor , Fioravanti Reinaldo 
Published: March 2023

Abstract
Unilateral open skies policy in the Dominican Republic produces large gains in welfare through the channel of competition between airlines. We document the effect of this policy on GDP and the flow of passengers. Using a synthetic difference-in-differences model, we find evidence that the reforms increased the GDP per capita in figures between 3.2% and 6.2% on average in five years (2007–2012). From difference-in-differences models, we find that the flow of American passengers increased by 30 percent in the years following the 2006 reforms. We also show that the market shares of airliners fell 30 percent on average for the same period. (JEL D12, L11, L51, L83, L98)
A study on the performance evaluation system for Supercomputer Joint Utilization System
Authors: Shim Hyungwook , Hahm Jaegyoon 
Published: March 2023

Abstract
A joint utilization system was established to efficiently use domestic supercomputer resources at the national level in Republic of Korea. Institutions participating in the joint utilization system are selected through a designation evaluation, and are subject to performance evaluation every five years on whether or not they are re-designated. Re-designation is determined by a total score of 70 points or higher based on the operation guidelines of the specialized center. Therefore, it is very important to establish an appropriate performance evaluation system, and the appropriateness of the performance evaluation model was verified prior to re-designation evaluation.As a result of the analysis, an improvement plan was derived by considering the network structure and connection strength between evaluation items, and the degree of improvement of the evaluation model could be confirmed.
A Digital Twin-driven Multi-resource Constrained Location System for Resource Allocation
Authors: Tang Qi , Wu Baotong 
Published: March 2023

Abstract
Smart manufacturing systems combine sensor systems and manufacturing processes, and they have been widely adopted in the industry to solve real production problems, help manufacturing enterprises achieve rapid decision making, and improve manufacturing value. However, manufacturing enterprises still face huge challenges with the coexistence of continuously changing dynamic demands, collaborative scheduling of dynamic resources, precise matching of manufacturing resources, and multiple resource constraints. To address this challenge, this research combines digital twin (DT) technology to propose a smart site-selection system with dynamic resource-accurate matching characteristics based on the attributes and associations of both resource sides, supply and demand sides, and site-selection sides, which can integrate and optimize resources according to the requirements of manufacturing tasks. In addition, by establishing the discovery mechanism of bottleneck processes and resource allocation methods, generating configuration priorities and thus reducing the solution space for resource allocation, the precise allocation of limited resources is achieved more quickly and easily, and the scheduling chaos in the parallel scheduling of multiple resources is solved and the multi-objective robust optimization model is solved by combining smart optimization algorithms. Combined with the example analysis, the results show that the smart site-selection system and multi-resource cyclic allocation mechanism proposed in this paper can collaboratively match a large amount of dynamic resources, and the utilization rate of idle manufacturing resources can be increased by 60%. This research effectively realizes the optimal allocation of multiple manufacturing resources in a resource-constrained environment and helps manufacturing enterprises create more manufacturing value.
WITHDRAWN: Prone-position versus usual care in hypoxemic COVID-19 patients in medical wards: a randomized controlled trial
Authors: NAY Mai-Anh , HINDRE Raphaël , PERRIN Christophe , CLÉMENT Jérémy , PLANTIER Laurent , SÈVE Aymeric , DRUELLE Sylvie , MORRIER Marine , LAINÉ Jean-Baptiste , COLOMBAIN Léa , CORVAISIER Grégory , BIZIEN Nicolas , POUGET-ABADIE Xavier , BIGOT Adrien , JAMARD Simon , NYAMANKOLLY Elsa , PLANQUETTE Benjamin , FOSSAT Guillaume , BOULAIN Thierry 
Published: March 2023

Abstract
Background: Benefit of early awake prone positioning (PP) for COVID-19 patients hospitalised in medical wards and who need oxygen therapy remains to be demonstrated. The question was considered at the time of COVID-19 pandemic to avoid overloading the intensive care units. We aimed to determine whether PP plus usual care could reduce the rate of non-invasive ventilation (NIV) or intubation or death as compared with usual care alone.
Methods: In this multicentre randomised clinical trial, 268 patients were randomly assigned to awake PP plus usual care (N=135) or usual care alone (N=132). The primary outcome was the proportion of patients who underwent NIV or intubation or died within 28 days. Mains secondary outcomes included the rates of NIV, of intubation or death, within 28 days.
Results: The proportion of NIV or intubation or death within 28 days was 14.1% (19/135) in the PP group and 12.9% (17/132) in the usual care group (odds ratio adjusted for stratification [aOR] 0.43; 95% confidence interval [CI] 0.14 to 1.35). The probability of intubation, or intubation or death (secondary outcomes) was reduced in the PP versus usual care group (aOR 0.11; 95%CI 0.01 to 0.89 and aOR 0.09; 95%CI 0.01 to 0.76, respectively) in the whole study population and in the prespecified subgroup of patients with SpO2 ≥95% on inclusion (aOR 0.11; 95%CI 0.01 to 0.90, and aOR 0.09; 95%CI 0.03 to 0.27, respectively).
Conclusions: Awake PP plus usual care in COVID-19 patients in medical wards did not decrease the need for NIV or intubation or death.
Trial registration: ClinicalTrials.gov Identifier: NCT04363463. Registered 27 April 2020.
Simulation of 3D wave propagation in thermoelastic anisotropic media
Authors: Carcione José M. , Wang Enjiang , Qadrouh Ayman N. , Alajmi Mamdoh , Ba Jing 
Published: March 2023

Abstract
We develop a numerical algorithm for simulation of wave propagation in anisotropic thermoelastic media, established with a generalized Fourier law of heat conduction. The wavefield is computed by using a grid method based on the Fourier differential operator and a first-order explicit Crank-Nicolson algorithm to compute the spatial derivatives and discretize the time variable (time stepping), respectively. The model predicts four propagation modes, namely, a fast compressional or (elastic) P wave, a slow thermal P diffusion/wave (the T wave), having similar characteristics to the fast and slow P waves of poroelasticity, respectively, and two shear waves, one of them coupled to the P wave and therefore affected by the heat ow. The thermal mode is diffusive for low values of the thermal conductivity and wave-like for high values of this property. As in the isotropic case, three velocities define the wavefront of the fast P wave, i.e, the isothermal velocity in the uncoupled case, the adiabatic velocity at low frequencies, and a higher velocity at high frequencies. The heat (thermal) wave shows an anisotropic behavior if the thermal conductivity is anisotropic, but an elastic source does not induce anisotropy in this wave if the thermal properties are isotropic.
Comparison of shaping ability and cutting efficiency of a novel rotary file system (Trunatomy) versus Protaper Next and 2Shape in severely curved mandibular mesiobuccal canals (An in vitro study)
Authors: Ewis Rana Mohamed , Lutfy reem ahmed , Elkhodary sherif adel , Elkhodary sherif adel 
Published: March 2023

AbstractIntroduction:This study aimed to compare the shaping ability and cutting efficiency of Trunatomy, Protaper Next and 2Shape file systems in preparing severely curved canals.Methods:Forty-five mandibular mesiobuccal canals with 40-60 degrees of curvature were divided into three equal groups: Trunatomy, Protaper Next and 2Shape. Pre- and post-instrumentation images were taken using cone beam computed tomography to measure canal transportation, centering ability, dentin thickness and canal curvature radius and volume. Pre- and post-instrumentation weights were measured using ananalytical scale.Results:Trunatomy had significantly the lowest values of canal transportation, amount of removed dentin and percent change in canal curvature radius and volume. Protaper Next had significantly the highest buccolingual canal transportation. There was no significant difference among the three systems in canal centering. Trunatomy significantly recorded lesser percent change in root canal weightthan 2Shape.Conclusion:The three file systems were able to prepare severely curved root canals efficiently and safelyClinical relevance:Trunatomy system can prepare root canals with severe curvature and complex anatomy with minimal amount of removed dentin.