bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developments in the Liturgical Life of the Savior Transfiguration Valaam Monastery in 1830s
Authors: Сергеев Г.Б. 
Published: March 2023

В настоящей статье рассматриваются изменения в литургической жизни Валаамской обители, происходившие в 1833-1839 гг. - при игумене Вениамине (Мануйлове), а также отношение к этим изменениям со стороны монастырской братии и священноначалия, в частности тогдашнего благочинного монастырей Санкт-Петербургской епархии свт. Игнатия (Брянчанинова). Дабы показать реальные изменения в богослужебной жизни обители, возражения братии, ревновавшей о сохранении устава, и заключение высшей церковной власти, автор опирается на документы архивных фондов Святейшего Синода и Санкт-Петербургской Духовной консистории. Для рассмотрения литургической жизни монастыря привлекается исторический контекст, иллюстрирующий то, как различные факторы могут влиять на восприятие братией изменений в богослужении. По итогам исследования делается вывод: поскольку богослужение является сердцевиной жизни монашеской общины, постольку незначительные, с точки зрения общего устава, перемены в порядке совершения служб не должны сопровождаться ощутимым смущением и разделением среди братии, какими бы законными эти перемены ни были. Более того, из истории Валаамского монастыря можно видеть, что не все кажущиеся необходимыми изменения действительно оказываются таковыми по прошествии некоторого времени, а также после принятия иных, более уместных в конкретной ситуации решений.
Abstract In the present article the changes in the liturgical life of the Valaam monastery, happened in the reign of heg. Benjamin (Manuilov; 1833-1839), also the relation to them of the monastery brotherhood and the hierarchy - particularly of then rural dean of the St.-Petersburg eparchy monasteries st. Ignatius (Brianchaninov) - are reviewed. To show the real changes in the worship life of the monastery, the objections of the brotherhood being zealous of the monastic rules conservation and the hierarchy conclusion the author leans on the documents of the Holy Synod and St.-Petersburg Consistory archival collections. When considering the monastery liturgical life issue the historical context is involved, illustrating how the various factors can affect the perception of the changes in the worship by the brotherhood. As a research result the conclusion is drawn: as the worship is the heart of the monastic community life, so the insigni cant, from the point of view the church discipline, changes in the services performance order shouldn’t be accompanied by the appreciable confusion and division among the brotherhood, however legal these changes are. Moreover, from the history of the Valaam monastery man can see that not all changes seeming necessary prove to be such after some time has elapsed, as well as after the different, more appropriate in the concrete case solutions.
Metropolitan Districts and Metropolises in the Recent History of the Russian Orthodox Church
Authors: Звонарёв С. 
Published: March 2023

Церковные области, созданные в Русской Православной Церкви в 1928 и 1934 годах, долго не просуществовали, а потому не оказали заметного влияния на церковную жизнь. Однако идея окружного объединения нескольких епархий не была позабыта. С появлением благоприятных условий она получила новое развитие уже в наши дни в проекте создания митрополичьих округов и митрополий. Целью предлагаемого читателю текста небольшого исследования, завершающего трилогию статей автора на тему церковных округов, является сопоставление статуса, полномочий органов управления митрополичьих округов и митрополий, в том числе применительно к опыту конструирования региональных церковных центров столетней давности. Для достижения цели используется метод сравнительного исторического и церковно-правового анализа. Созданные экспертами и церковным законодателем территориальные канонические структуры в виде митрополичьих округов и митрополии как формы объединения нескольких епархий стали уникальным в своём роде опытом проектирования региональных церковных центров. Выйдя за пределы пастырско-миссионерских задач, что являлось константой всего предшествующего опыта построения окружного митрополичьего управления, современные митрополичьи округа наделены административно-судебными полномочиями, а митрополии - административными. Как это проявилось в деталях конструкции региональных церковных центров, мы рассмотрим ниже.
The Church areas created in the Russian Orthodox Church in 1928 and 1934 did not exist long, and therefore did not have a noticeable impact on Church life. However, the idea of creating Church areas which united several dioceses was not forgotten. With the appearance of favorable conditions, nowadays this idea received a new development in the project of creating metropolitan areas and metropolias. The purpose of this article is to compare the status and powers of the governing bodies of metropolitan areas and metropolias, including the experience of creating regional Church centers a century ago. To achieve this goal, the method of comparative historical and сhurch-legal analysis was used. The territorial canonical structures created by experts and the Church legislator in the form of metropolitan areas and metropolias by uni cation of several dioceses have become a unique experience in designing regional Church centers. Having gone beyond the limits of pastoral and missionary tasks, which was a constant of all previous experience in building metropolitan areas administrations, modern metropolitan areas are endowed with administrative and judicial powers, and metropolias with administrative powers. In this work we are going to consider how this manifested itself in the details of the construction of regional Church centers.
Buddhist art of Gandhāra: a catalogue of newly documented sites in Malakand District
Authors: Naz Fozia 
Published: March 2023

In respect to Gandhāra civilization, antiquarians and archaeologists have made many discoveries in ancient Uḍḍiyāna (Swat) and the present-day Khyber Pakhtunkhwa region of Pakistan. Historically and geographically, ancient Uḍḍiyāna (Swat) occupies an important position in South and Central Asia. From the nineteenth century, archaeological explorations have entailed surveys and excavations of many sites within the confines of Uḍḍiyāna (Faccenna 1980; Stacul 1989; Callieri 2005). These sites included structural remains and cultural artefacts, consisting of pottery, coins, Buddhist sculptures, decorated stone fragments, and jewelry. The region remains rich in archaeological evidence for the explanation of the Buddhist period. The district of Malakand is one of the most important valleys among the archaeological sites of the Gandhāra region. Many examples of Buddhist-period rock art have also been reported there and their relevance to Gandhāran art has been discussed in previously published survey results (Naz 2020; Naz and Sardar 2021). The present paper will summarize Buddhist art recorded from different sites in Malakand District (Map 1). A newly documented Muslim-period graveyard with abundant, reused Buddhist sculptural fragments is also included in this article. The Gandhāran art collections in Swat, Peshawar and Chakdara Museums are not included in this paper.
Keikutsertaan Masyarakat Muslim dalam Upacara Tiwah Agama Hindu Kaharingan di Kota Palangka Raya
Authors: Helim Abdul , Tiara Syahriana Unggun 
Published: March 2023

This study tries to answer on kinds of things followed by Dayak Ngaju Tribe Muslim Community Palangka Raya city in Tiwah Ceremony of Hindu Kaharingan and the reasons why they participate on the ceremony. This problem is studied by qualitative description by using cultural and religious approaches. The study results find out that most of Muslim community only participate some series of tiwah ceremony considered to be still tolerated by Islam, meanwhile for some other small parts, they still participated on them but they just do it not by full-hearted. Their participation on the tiwah ceremony is as a honor for their parents and family having their own history in their life. The participation model of Dayak Ngaju Tribe Muslim Community which is only in still tolerated things in Islam activities can be considered as the local Islamic tradition.
THAWAF IFADHAH BAGI PEREMPUAN HAID
Authors: Wisnarni Wisnarni 
Published: March 2023

Pelaksanaan tawaf ifadhah harus dilakukan dalam keadaan suci. Sehingga Nabi saw. melarang wanita haid melaksanakan tawaf. Terjadi perbedaan pendapat dikalangan ulama dalam menanggapi hal ini, pertama menurut jumhur wanita yang mengalami haid ketika musim haji harus menunggu hingga suci untuk dapat melaksanakan tawaf ifadhah. Kedua ulama mazhab hanafi berpendapat bahwa suci akan merupakan syarat sah tawaf ifadhah, sehingga diperbolehkan bagi wanita haid untuk melaksanakan tawaf dengan catatan harus menimpalinya dengan membayar dam.
Debiasing and Educational Interventions in Medical Diagnosis: A Systematic Review
Authors: Tung Arthur , Melchiorre Michael 
Published: March 2023

Background: The prevalence of cognitive bias and its contribution to diagnostic errors has been documented in recent research. Debiasing interventions or educational initiatives are key in reducing the effects and prevalence of cognitive biases, contributing to the prevention of diagnostic errors. The objectives of this review were to 1) characterize common debiasing strategies implemented to reduce diagnosis-related cognitive biases, 2) report the cognitive biases targeted, and 3) determine the effectiveness of these interventions on diagnostic accuracy.
Methods: Searches were conducted on April 25, 2022, in MEDLINE, EMBASE, Healthstar, and PsycInfo. Studies were included if they presented a debiasing intervention which aimed to improve diagnostic accuracy. The Rayyan review software was used for screening. Quality assessments were conducted using the JBI Critical Appraisal Tools. Extraction, quality assessment and analysis were recorded in Excel.
Results: Searches resulted in 2232 studies. 17 studies were included in the final analysis. Three major debiasing interventions were identified: tool use, education of biases, and education of debiasing strategies. All intervention types reported mixed results. Common biases targeted include confirmation, availability, and search satisfying bias.
Conclusion: While all three major debiasing interventions identified demonstrate some effectiveness in improving diagnostic accuracy, included studies reported mixed results when implemented. Furthermore, no studies examined decision-making in a clinical setting, and no studies reported long-term follow-up. Future research should look to identify why some interventions demonstrate low effectiveness, the conditions which enable high effectiveness, and effectiveness in environments beyond vignettes and among attending physicians.
PROSPERO registration number: CRD42022331128
Development of three-dimensional primary human myospheres as culture model of skeletal muscle cells for metabolic studies
Authors: Dalmao-Fernandez Andrea , Aizenshtadt Aleksandra , Bakke Hege G. , Krauss Stefan , Rustan Arild C. , Thoresen G. Hege , Kase Eili Tranheim 
Published: March 2023

Introduction: Skeletal muscle is a major contributor to whole-body energy homeostasis and the utilization of fatty acids and glucose. At present, 2D cell models have been the most used cellular models to study skeletal muscle energy metabolism. However, the transferability of the results to in vivo might be limited. This project aimed to develop and characterize a skeletal muscle 3D cell model (myospheres) as an easy and low-cost tool to study molecular mechanisms of energy metabolism.Methods and results: We demonstrated that human primary myoblasts form myospheres without external matrix support and carry structural and molecular characteristics of mature skeletal muscle after 10 days of differentiation. We found significant metabolic differences between the 2D myotubes model and myospheres. In particular, myospheres showed increased lipid oxidative metabolism than the 2D myotubes model, which oxidized relatively more glucose and accumulated more oleic acid.Discussion and conclusion: These analyses demonstrate model differences that can have an impact and should be taken into consideration for studying energy metabolism and metabolic disorders in skeletal muscle.
Causes of permanent vertical deformation at subduction margins: Evidence from late Pleistocene marine terraces of the southern Hikurangi margin, Aotearoa New Zealand
Authors: Ninis Dee , Howell Andy , Little Timothy , Litchfield Nicola 
Published: March 2023

Theoretical studies of the seismic cycle at convergent plate boundaries anticipate that most coseismic deformation is recovered, yet significant permanent vertical displacement of the overriding plate is observed at many subduction margins. To understand the mechanisms driving permanent vertical displacement, we investigate tectonic uplift across the southern Hikurangi subduction margin, Aotearoa New Zealand, in the last ∼200 ka. Marine terraces preserved along the Wellington south coast have recently been dated as Marine Isotope Stage (MIS) 5a (∼82 ka), 5c (∼96 ka), 5e (∼123 ka) and 7a (∼196 ka) in age. We use these ages, together with new reconstructions of shoreline angle elevations, to calculate uplift rates across the margin and to examine the processes responsible for their elevation. The highest uplift rate—1.7 ± 0.1 mm/yr–and maximum tilting—2.9° to the west–are observed near Cape Palliser, the closest site to (∼50 km from) the Hikurangi Trough. Uplift rates decrease monotonically westward along the Palliser Bay coast, to 0.2 ± 0.1 mm/yr at Wharekauhau (∼70 km from the trough), defining a gently west-tilted subaerial forearc domain. Locally, active oblique-slip upper-plate faults cause obvious vertical offsets of the marine terraces in the axial ranges (&gt;70 km from the trough). Uplift rates at Baring Head, on the upthrown side of the Wairarapa-Wharekauhau fault system, are ∼0.7–1.6 mm/yr. At Tongue Point, uplift on the upthrown side of the Ōhāriu Fault is 0.6 ± 0.1 mm/yr. Dislocation and flexural-isostatic modelling shows that slip on faults within the overriding plate—specifically the Palliser-Kaiwhata Fault and the Wairarapa-Wharekauhau fault system—may dominate uplift in their immediate hanging walls. Depending on their slip rate and geometry, slip on these two upper-plate fault systems could plausibly cause &gt;80% of late Pleistocene uplift everywhere along the south coast of North Island. Our modelling suggests that subduction of the buoyant Hikurangi Plateau contributes uplift of 0.1–0.2 mm/yr and uplift due to sediment underplating at Tongue Point and Wharekauhau is likely ≤0.6 mm/yr but could be significantly lower. Earthquakes on the subduction interface probably contribute ≤0.4 mm/yr of late Pleistocene uplift, with ≤10% of uplift due to each earthquake being stored permanently, similar to other subduction zones. These results indicate a significant contribution of slip on upper-plate faults to permanent uplift and tilting across the subduction margin and suggest that in regions where upper-plate faults are prevalent, strong constraints on fault geometry and slip rate are necessary to disentangle contributions of deeper-seated processes to uplift.
Integrated analysis of genome-wide gene expression and DNA methylation profiles reveals candidate genes in ovary endometriosis
Authors: Lei Lei , Xu Xinxin , Gong Chengchen , Lin Bowen , Li Fang 
Published: March 2023

BackgroundThe incidence of endometriosis (EMs), a common disease in gynecology, has increased over the years. Women suffer from the symptoms caused by EMs, such as chronic pelvic pain, dysmenorrhea, and infertility. However, the etiology and pathophysiology of EMs remain unclear. This study aimed to identify candidate genes of endometriosis through integrated analysis of genome-wide gene expression and DNA methylation profiles.ResultsEutopic and ectopic endometrial tissues were collected from patients who were diagnosed as ovarian EMs. Genome-wide methylation profiling identified 17551 differentially methylated loci, with 9777 hypermethylated and 7774 hypomethylated loci. Differentially methylated loci were mainly concentrated in the gene body and intergenic regions. Genome-wide gene expression profiling identified 1837 differentially expressed genes (DEGs), with 1079 genes upregulated and 758 downregulated in ectopic groups. Integrated analysis revealed that DNA methylation was negatively correlated to gene expression in most genomic regions, such as exon, 3’UTR, 5’UTR, and promoter. We also identified promoter-related (53 downregulated and 113 upregulated) and enhancer-related DMGs (212 downregulated and 232 upregulated), which were significantly correlated to the gene expression. Further validation of the top-ranked genes belonging to differentially methylated genes (DMGs) and DEGs revealed that TMEM184A, GREM2, SFN, KIR3DX1, HPGD, ESR1, BST2, PIK3CG and RNASE1 were significant candidate genes in ovarian endometriosis.ConclusionOur study revealed the significance of DNA methylation in the gene expression in ovary endometriosis, which provides new insights and a molecular foundation for understanding the underlying mechanisms of endometriosis.
Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration
Authors: Jansen Kirsten M. , Dahdah Norma , Gama-Perez Pau , Schots Pauke C. , Larsen Terje S. , Garcia-Roves Pablo M. 
Published: March 2023

ObjectiveTo compare administration of the glucagon-like peptide-1 (GLP-1) analogue, exenatide, versus dietary supplementation with the omega-3 fatty acid-rich Calanus oil on obesity-induced alterations in mitochondrial respiration.MethodsSix-week-old female C57BL/6JOlaHSD mice were given high fat diet (HFD, 45% energy from fat) for 12 weeks to induce obesity. Thereafter, they were divided in three groups where one received exenatide (10 μg/kg/day) via subcutaneously implanted mini-osmotic pumps, a second group received 2% Calanus oil as dietary supplement, while the third group received HFD without any treatment. Animals were sacrificed after 8 weeks of treatment and tissues (skeletal muscle, liver, and white adipose tissue) were collected for measurement of mitochondrial respiratory activity by high-resolution respirometry, using an Oroboros Oxygraph-2k (Oroboros instruments, Innsbruck, Austria).ResultsIt was found that high-fat feeding led to a marked reduction of mitochondrial respiration in adipose tissue during all three states investigated – LEAK, OXPHOS and ETS. This response was to some extent attenuated by exenatide treatment, but not with Calanus oil treatment. High-fat feeding had no major effect on hepatic mitochondrial respiration, but exenatide treatment resulted in a significant increase in the various respiratory states in liver. Mitochondrial respiration in skeletal muscle was not significantly influenced by high-fat diet or any of the treatments. The precise evaluation of mitochondrial respiration considering absolute oxygen flux and ratios to assess flux control efficiency avoided misinterpretation of the results.ConclusionsExenatide increased hepatic mitochondrial respiration in high-fat fed mice, but no clear beneficial effect was observed in skeletal muscle or fat tissue. Calanus oil did not negatively affect respiratory activity in these tissues, which maintains its potential as a dietary supplement, due to its previously reported benefits on cardiac function
The effect of G0S2 on insulin sensitivity: A proteomic analysis in a G0S2-overexpressed high-fat diet mouse model
Authors: Wu Dongming , Zhang Zhenyuan , Sun Wenxiu , Yan Yong , Jing Mengzhe , Ma Shizhan 
Published: March 2023

BackgroundPrevious research has shown a tight relationship between the G0/G1 switch gene 2 (G0S2) and metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and obesity and diabetes, and insulin resistance has been shown as the major risk factor for both NAFLD and T2DM. However, the mechanisms underlying the relationship between G0S2 and insulin resistance remain incompletely understood. Our study aimed to confirm the effect of G0S2 on insulin resistance, and determine whether the insulin resistance in mice fed a high-fat diet (HFD) results from G0S2 elevation.MethodsIn this study, we extracted livers from mice that consumed HFD and received tail vein injections of AD-G0S2/Ad-LacZ, and performed a proteomics analysis.ResultsProteomic analysis revealed that there was a total of 125 differentially expressed proteins (DEPs) (56 increased and 69 decreased proteins) among the identified 3583 proteins. Functional enrichment analysis revealed that four insulin signaling pathway-associated proteins were significantly upregulated and five insulin signaling pathway -associated proteins were significantly downregulated.ConclusionThese findings show that the DEPs, which were associated with insulin resistance, are generally consistent with enhanced insulin resistance in G0S2 overexpression mice. Collectively, this study demonstrates that G0S2 may be a potential target gene for the treatment of obesity, NAFLD, and diabetes.
Gelsolin: A comprehensive pan-cancer analysis of potential prognosis, diagnostic, and immune biomarkers
Authors: Wang Yiyang , Bi Xiaojuan , Luo Zhiwen , Wang Haiyan , Ismtula Dilimulati , Guo Chenming 
Published: March 2023

Introduction: Gelsolin (GSN), a calcium-regulated actin-binding protein, is out of balance in various cancers. It can mediate cytoskeletal remodeling and regulate epithelial-mesenchymal conversion (EMT), but the studies on GSN function in pan-cancer are limited.Methods: We studied the transcription level, prognostic impact, diagnostic value, genetic, epigenetic modification, methylation level and immune significance of GSN in pan-cancer to fully comprehend the function of GSN in various malignancies based on multiple databases like The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO).Results: Pan-cancer research showed that GSN was downregulated in most tumors and expressed differently in immunological and molecular subtypes of many cancers. GSN had varying impacts on the prognosis of various tumor types. However, all had moderate to high diagnostic efficiency, and serum GSN had good diagnostic value in breast cancer patients (AUC = 0.947). Moreover, GSN was a distinguishing prognosis factor for some specific cancer types. The GSN protein was hypophosphorylated, and its promoter was hypermethylated in most cancers. GSN was linked to the infiltration level of several immunity cells and was essential in anti-tumor immune cell infiltration. KEGG and GSEA analyses showed that GSN was vital in the functions and proteoglycans processes in cancer, chemokine signaling pathway and other immune-related pathways, DNA methylation and cell cycle.Discussion: In conclusion, GSN possesses the ability to be a predictive, diagnostic, and immune indicator in pan-cancer.