bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications of total knee arthroplasty and the development of late deep infection in patients with rheumatoid arthritis
Authors: YAZICI Alikemal 
Published: April 2023

Aim: This study aimed to assess complications and the presence of late deep infection in patients with rheumatoid arthritis (RA) who underwent primary and revision total knee arthroplasty (TKA).
Materıial and Method: Between June 1997 and October 2022, cemented TKA that cut the posterior cruciate ligament (PCL) was applied to 50 knees of 34 patients with RA, and posterior-stabilized (PS) revision TKA was applied to 7 knees of 5 patients. All the patients enclosed in this study were adults diagnosed with RA by a rheumatology or physical therapy physician according to the RA diagnostic criteria recommended by the American College of Rheumatology in 1987. The diagnosis of infection was based on the Periprosthetic Infection Diagnostic Criteria of the 2018 International Periprosthetic Joint Infections Consensus Meeting.
Results: Complications were found in 9 (18%) of the 50 knees who underwent primary TKA. Postoperative serous discharge was observed in 3 (6%) knees, serous discharge and late partial rupture of the quadriceps tendon in 1 (2%), early deep infection in 1 (2%), late deep infection in 3 (6%), and hematoma in 1 (2%). Revision surgery was performed on 3 (6%) knees due to infection and on 4 (8%) knees due to aseptic loosening. Complications developed in 2 of these knees who underwent revision TKA, 1 (14.3%) knee with periprosthetic fracture in the femur in the first postoperative year, and 1 (14.3%) knee with early deep infection. Deep vein thrombosis (DVT), pulmonary emboli (PE) and heterotopic ossification (HO) were not observed in any patient.
Conclusion: In patients with rheumatoid arthritis, total knee arthroplasty increased chronic late deep infection and the associated need for revision surgery, and decreased the rates of DVT, PE, HO.
Does recipient weight and surgical approach really matter in pediatric renal transplantation?
Authors: EREN Eryigit , DİNÇKAN Ayhan 
Published: April 2023

Aim: To compare the outcomes between low-weight (15 kg) children who underwent renal transplantation (RT) and investigate the impact of the surgical approach (intraperitoneal or extraperitoneal RT).
Material and Method: This study was designed as an observational single-centre study and was conducted in Istinye University Hospital, Istanbul, Turkey, between January 2018 and June 2021. Data including age, gender, weight, surgical approach (intraperitoneal/extraperitoneal), complications, length of hospital stay, graft and patient survival were collected. Low-weight (LW) and normal-weight (NW) patients were compared. A p value less than 0.05 was considered statistically significant.
Results: Overall, 107 (33 LW and 74 NW) patients aged between 1 and 17 were included. The LW group had a significantly lower age and a significantly longer duration of intensive care unit (ICU), and inpatient floor stays than the NW group (p
The late-term results in our patients operated for lumbar spine fractures
Authors: İZCİ Emir , PEKİNCE Oguzhan , KESKİN Fatih 
Published: April 2023

Aim: The current study aimed to evaluate the late-term results of patients operated for lumbar spine fractures in our clinic.
Material and Method: 134 patients from January 2012 to January 2020 were treated with “short-segment pedicle instrumentation” for lumbar fractures in our neurosurgery department. Patients with a burst fracture of a single lumbar vertebra were included. The final sample consisted of 67 patients who were followed up over the years with radiographs before and after surgery and CT scans at the final follow-up.
Results: The results showed that 60% of the patients were rated as Denis P1, 35% as P2, and 5% as P3. Screw breakage was observed in seven patients, and 67 patients underwent revision surgery. Furthermore, the fractured vertebral body’s height was improved at the final follow-up stage, and an increase was witnessed from the preoperative figure of 16.4 mm to 25.8 at the final follow-up. At the final follow-up, the average Cobb angle was -11.6° preoperatively, and 6.3° after the operation and the correction loss was 12.1° which was severe in the middle part of the vertebra. By the final follow-up, disc spaces were narrowed below and above the fractured vertebra, and no correlation was found between clinical outcomes and adjacent disc degeneration.
Conclusion: We concluded that short-segment pedicle instrumentation produced satisfactory long-term results for lumbar fractures. To achieve adequate outcomes, correct management of complications and evaluation of various factors must be focused on.
The relationship between levels of apolipoprotein A1 and B in aqueous and serum with stage of diabetic retinopathy
Authors: ERBAHÇECİ TİMUR İnci Elif , ÖRNEK Kemal , ÇAĞLAYAN Osman 
Published: April 2023

Aim: To determine the association between serum and aqueous apolipoprotein (Apo) A1 and Apo B levels and Apo B/A1 ratio in diabetic retinopathy.
Material and Method: This cross-sectional prospective study included 63 diabetic patients with or without retinopathy and 38 control subjects who underwent cataract surgery. The study groups were as follows; healthy subjects (Group 1), diabetic patients without retinopathy (Group 2), with non-proliferative diabetic retinopathy (Group 3), and with proliferative diabetic retinopathy (Group 4). Serum and aqueous Apo A1 and Apo B levels were determined by using an enzyme-linked immunosorbent assay.
Results: The amount of Apo B was determined in aqueous samples of all (100%) patients in Group 4 and 77.7% of patients in Group 3.The mean serum Apo B/A1 ratio was significantly higher in Group 2, Group 3 and Group 4 compared with Group 1 (p=0.002, p=0.037 and p
Paired Reading and Paired Summarizing Strategy: Exploring Motivation and Effects Of EFL Students’ Reading Comprehension
Authors: Triana Neni 
Published: April 2023

Paired Reading and Paired summarizing is one teaching strategy that can use in teaching reading. The main purpose of this study is to find out the effects of Paired Reading and Paired Summarizing Strategy on students’ reading comprehension and motivation at SMK Abdurrab Pekanbaru. The design of this research is a quasi-experiment design with pre-test and post-test procedures. The total population is 97 students of the tenth grade. This research uses a cluster sampling technique to get samples. The total sample is 64 students. The sample is divided into two classes; the experimental class and the control class. The data are analyzed using the t-test method to find out whether there is a significant difference between the experimental class taught by using Paired Reading and Paired Summarizing as a treatment, and the control class is taught conventionally. it found that significant probabilities are higher than 0.05meaning that there is a significant difference in students' reading comprehension and learning motivation in the pre-test of both classes and post-test of both classes, and there is a significant difference in students' reading comprehension and learning motivation pre-test and post-test of experimental class. There is an effect of using Paired Reading and Paired Summarizing on students’ reading comprehension and learning motivation. At last, it suggested that the English teachers Paired Reading and Paired Summarizing in teaching are reading.
Use of Audiovisual Media to Improve Learning Outcomes in Writing Fable Stories for Class X Students of SMKN 1 Sengkang
Authors: Basir Sutrisman , Anies Siti Hasriyati , Kadir Abdul , Herniyastuti Herniyastuti 
Published: April 2023

This research is a class action research that aims to find out how the application of Audiovisual Media in Improving Learning Outcomes of Class X Students of SMK Negeri 1 Sengkang. This type of research is class action research (PTK). The research consists of three stages, namely precyclical, cycle I, and cycle II. Data collection techniques are carried out by tests and nontests. Test techniques are in the form of written tests of writing fables, while non-test techniques include observation techniques, questionnaires, interviews, field notes, and documentation. The instruments used in this study were test and non-test instruments. In data analysis, qualitative and quantitative techniques are used. The aspects observed are changes in student attitudes during the learning process using audiovisual media carried out quite well and changes in student attitudes and student learning outcomes have improved. This can be seen from the percentage of learning outcomes in the precyclical stage of only 58.00%. After applying audiovisual media, student learning outcomes increased to 70.56% in cycle I and increased again to 86.75% in cycle II. Thus, it can be concluded that there is an increase in learning outcomes in writing fable stories by applying the concept of audiovisual media to class X students of SMK Negeri 1 Sengkang.
Enhancing Students’ Speaking Ability Using the Plan-Ahead Brainstorming Technique
Authors: Affandi Akhmad , Muhalim Muhalim 
Published: April 2023

This research aimed at finding out whether or not the use of Plan-ahead Brainstorming in helping the second-year students of SMAN 1 Bantaeng to enhance their speaking skill. The steps of Plan-ahead Brainstorming in implementing consist of (1) giving the topic, (2) plan-ahead session, (3) brainstorming in small group, (4) individual oral report. This research employed pre-experimental method. The researcher used random sampling technique and the selected sample was the students in XI IPA1 with the total 28 number of students. The instrument of this research was speaking test in the form of oral test. The data acquired were then analyzed through descriptive and inferential statistics. The result of the data analysis showed that the probability value (0.00) was smaller than the level of significance (0.05). This indicated that the implementation of Plan-ahead Brainstorming enhanced the students` speaking skill. This indicates that the alternative hypothesis (H1) accepted. This research contributed extensively the theory about plan-ahead brainstorming in enhancing students speaking ability. The plan-ahead brainstorming is the technique that can influence the students speaking fluency effectively. The outcome of the use of plan-ahead brainstorming is useful in learning English, especially students in learning speaking. The student can decrease their skepticism and stammer in plan-ahead session to prepare what they want to utter. The researcher found that this technique is useful for teachers in order that they can use this technique more effectively as long as the teacher prepare specific time to implement this technique in several time.
The cyclic recurrence of scientific-technological and economic development in different types of economy as an example of petroleum-based weaponry (antiquity – the Middle Ages – contemporaneity) (Part 1)
Authors: Selishchev Nikolay 
Published: April 2023

It is considered the cyclic recurrence in development of mathematics and shipbuilding in different types of economy in connection with creation and application of petroleum-based weaponry (antiquity – the Middle Ages – contemporaneity). It is analyzed so called «fire-throwers» («iron braziers») of fleet of the ancient Rhodes merchant republic in context of discoveries by Russian archaeologists in Crimea, on Taman peninsula and in Azov seashore region the numerous ancient and medieval amphoras with petroleum, including the most early proto-Thasos amphora of 6th – 5th centuries B. C., which was studied in 2015–2016 years by method of mass-spectrometry. «Fire-throwers» of slave-owning Rhodes of 2nd century BC are compared with much more late «liquid» or «Greek fire» of feudal Byzantium of 7th – 12th centuries AD, it is proved, that this is the same weaponry. However in the EU reconstructions of the «Greek fire» such analysis doesn’t carry out. It is underlined the importance of application of agent-based simulations in reconstructions of battles of the past and role of the fundamental scientific studies in creation of new technologies
Recombinant production, purification, and biochemical characterization of a novel L-lactate dehydrogenase from Bacillus cereus NRC1 and inhibition study of mangiferin
Authors: Esa Sayed S. , El-Sayed Ahmed F. , El-Khonezy Mohamed I. , Zhang Shubing 
Published: April 2023

Lactate dehydrogenase (LDH, EC 1.1.1.27) is one of the vital glycolytic conditions, especially during anaerobic conditions. It is a significant diagnostic, prognostic, and monitoring biomarker parameter. A 950-bp DNA fragment containing the gene (LDH) encoding LDH was amplified from Bacillus cereus NRC1. The deduced amino acid sequence reveals that B. cereus LDH (Bc-LDH) is highly homologous to the LDHs of Bacillus organisms. All LDH enzymes have a significant degree of conservation in their active site and several additional domains with unidentified functions. The gene for LDH, which catalyzes lactate synthesis, was cloned, sequenced (accession number: LC706200.1), and expressed in Escherichia coli BL21 (DE3). In this investigation, Bc-LDH was purified to homogeneity with a specific activity of 22.7 units/mg protein and a molecular weight of 35 kDa. It works optimally at pH 8.0. The purified enzyme was inhibited by FeCl2, CuCl2, ZnCl2, and NiCl, whereas CoCl2 was found to boost the activity of Bc-LDH. The molecular docking of the 3D model of the Bc-LDH structure with a natural inhibitor, mangiferin, demonstrated excellent LDH inhibition, with a free binding energy of −10.2 kcal/mol. Moreover, mangiferin is a potent Bc-LDH inhibitor that inhibits Bc-LDH competitively and has one binding site with a Ki value of 0.075 mM. The LDH-mangiferin interaction exhibits a low RMSF value (&gt;1.5 Å), indicating a stable contact at the residues. This study will pave the way for more studies to improve the understanding of mangiferin, which could be considered an intriguing candidate for creating novel and improved LDH inhibitors.
Atomic scale insight into the decomposition of nanocrystalline zinc hydroxynitrate toward ZnO using Mn2+ paramagnetic probes
Authors: Vlaicu Ioana D. , Stefan Mariana , Radu Cristian , Culita Daniela C. , Radu Dana , Ghica Daniela 
Published: April 2023

Layered zinc hydroxynitrate (ZHN), with the chemical formula Zn5 (OH)8 (NO3)2·2H2O, exhibits a range of special properties such as anion-exchange and intercalation capacity, as well as biocompatibility, making it attractive for a large variety of applications in fields from nanotechnology to healthcare and agriculture. In this study nanocrystalline ZHN doped with 1,000 ppm Mn2+ was prepared by two synthesis methods (coprecipitation and solid state reaction) using similar environment-friendly precursors. The complex morpho-structural [X-ray diffraction, scanning and transmission electron microscopy, textural analysis] and spectroscopic [Fourier transform infrared and electron paramagnetic resonance (EPR)] characterization of the two ZHN nanopowders showed similar crystalline structures with Mn2+ ions localized in the nanocrystals volume, but with differences in their morphological and textural characteristics, as well as in the doping efficiency. ZHN obtained by coprecipitation consists of larger nanoplatelets with more than two times larger specific surface area and pore volume, as well as a dopant concentration than in the ZHN sample obtained by solid state reaction. The thermal stability and the on-set of the structural phase transformation have been investigated at atomic scale with high accuracy by EPR, using Mn2+ as paramagnetic probes. The on-set of the ZHN structural phase transformation toward ZnO was observed by EPR to take place at 110°C and 130°C for the samples prepared by coprecipitation and solid state reaction, respectively, evidencing a manganese induced local decrease of the transformation temperature. Our results contribute to the selection of the most appropriate ZHN synthesis method for specific applications and in the development of new green, cost-effective synthesis routes for Mn2+ doped nano-ZnO.
Clinical characteristics and management of immune checkpoint inhibitor-related cardiotoxicity: A single-center experience
Authors: Xiao Junjuan , Li Xingyu , Wang Xuan , Guan Yaping , Liu Hairong , Liang Jing , Li Yan , Wang Baocheng , Wang Jun 
Published: April 2023

BackgroundImmune checkpoint inhibitors (ICIs) have revolutionized cancer therapy in the past decade and amplify T-cell-mediated immune responses by disrupting immunoinhibitory signals. The augmented T-cell immune response has led to a range of immune-related adverse effects (irAEs). Immune-related cardiotoxicity has been reported in case series but has been underappreciated due to difficulties in diagnosis. This article describes epidemiological, clinical presentation, subtype, and treatment data and a new systematic framework for the clinical management of cardiotoxicity.MethodsData were extracted for cancer patients who received ICIs in a single center between January 1, 2020, and February 28, 2022. ICI-associated cardiotoxicity was clinically diagnosed based on clinical presentations, biochemical biomarkers, and imaging features.ResultsWe identified a total of 12 (2.46%) cases of ICI-related cardiotoxicity from 487 patients who received PD-1 or PD-L1 inhibitors. All patients were diagnosed with advanced or metastatic solid tumors. The severity of ICI-related cardiotoxicity ranged from subclinical cardiac abnormalities (subclinical type) with only asymptomatic troponin-I (TnI) elevations (25.0%) to symptomatic cardiac abnormalities (clinical type) (75.0%). Patients with symptomatic cardiac abnormalities had several manifestations, including tachyarrhythmia (16.7%), bradyarrhythmia (41.7%), or cardiac failure (8.3%). The median immunotherapy exposure time was 1.5 doses (range: 1 to 5), and the median time from the initial immunotherapy to the onset of ICI-related cardiotoxicity was 33.5 days (IQR: 20.3 to 46.8). Most patients, including those with subclinical cardiac abnormalities, were administered systemic corticosteroids (58.3%). One (8.3%) patient was put on mechanical ventilation, one (8.3%) received plasma exchange therapy, one (8.3%) was implanted with a pacemaker, and one (8.3%) was admitted to the ICU. Three patients with symptomatic cardiac abnormalities (25.0%) died, and other patients presented with significant clinical improvement with good outcomes.ConclusionICI-related cardiotoxicity is uncommon but critical with a high mortality rate and poor prognosis, especially for a small group of patients with symptomatic cardiac abnormalities. More attention should be given to cardiotoxicity associated with ICIs, and these patients should be given baseline examinations and biochemical analyses before and after the initiation of immunotherapy, intensive cardiac assessments, an accurate and rapid diagnosis, and timely multidisciplinary management with immunosuppressive agents and other necessary clinical interventions.
The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year
Authors: Mojón-Álvarez Diana , Izquierdo Andrea , Cubero-Gallego Héctor , Calvo-Fernández Alicia , Marrugat Jaume , Pérez-Fernández Silvia , Cabero Paula , Solà-Richarte Claudia , Soler Cristina , Farré Núria , Vaquerizo Beatriz 
Published: April 2023

Background and objectiveProlonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown. This study examined the relationship in COVID-19 survivors of a prolonged QTc on admission with long-term adverse events, changes in QTc duration and its impact on 1-year prognosis, and factors associated with a prolonged QTc at follow-up.MethodsWe conducted a single-center prospective cohort study of 523 SARS-CoV-2-positive patients who were alive on discharge. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval and repeated in 421 patients 7 months after discharge. Mortality, hospital readmission, and new arrhythmia rates 1 year after discharge were reviewed.ResultsThirty-one (6.3%) survivors had a baseline prolonged QTc. They were older, had more cardiovascular risk factors, cardiac disease, and comorbidities, and higher levels of terminal pro-brain natriuretic peptide. There was no relationship between prolonged QTc on admission and the 1-year endpoint (9.8% vs. 5.5%, p = 0.212). In 84% of survivors with prolonged baseline QTc, it normalized at 7.9 ± 2.2 months. Of the survivors, 2.4% had prolonged QTc at follow-up, and this was independently associated with obesity, ischemic cardiomyopathy, chronic obstructive pulmonary disease, and cancer. Prolonged baseline QTc was not independently associated with the composite adverse event at 1 year.ConclusionsProlonged QTc in the acute phase normalized in most COVID-19 survivors and had no clinical long-term impact. Prolonged QTc at follow-up was related to the presence of obesity and previously acquired chronic diseases and was not related to 1-year prognosis.
Duration and clinical outcomes of dual antiplatelet therapy following percutaneous coronary intervention for acute coronary syndrome: A multicentre “real-world practice” registry-based study
Authors: Vergara-Uzcategui Carlos E. , Moreno Víctor H. , Hennessey Breda , Sánchez-del-Hoyo Rafael , Donis José H. , Gonzalez-Rojas Jorgelys , Salinas Pablo , Nombela-Franco Luis , Gonzalo Nieves , Jimenez-Quevedo Pilar , Mejia-Renteria Hernán , Escaned Javier , Fernández Ortiz Antonio , Macaya Miguel Carlos , Núñez-Gil Iván J. 
Published: April 2023

BackgroundThe optimal duration of dual antiplatelet therapy (DAPT) ought to be determined taking into account individual ischaemic or bleeding events risks. To date, studies have provided inconclusive evidence on the effects of prolonged DAPT. We sought to evaluate the long-term outcomes of this strategy following percutaneous revascularization in the context of acute coronary syndrome (ACS).MethodsRetrospectively from four centers in Madrid, we identified 750 consecutive ACS patients, divided in two groups of DAPT duration: &lt;13 months and &gt;13 months, with a mean follow-up of 48 months.ResultsPatients with DAPT &gt; 13 months had a higher non-adjusted incidence of Major Adverse Cardiovascular Events (11.6% vs. 17.3%) and new revascularization (3.7% vs. 8.7%). Differences in all-cause death, cardiac death, myocardial infarction, stent thrombosis and stroke were non-significant. There was no difference in the incidence of major bleeding (7.4% vs. 6.3%). Multivariable Cox regression analysis showed that the independent risk predictors of MACE were age (HR: 1.04, 95% CI: 1.02–1.06, p &lt; 0.001) and multivessel disease (HR: 2.29, 95% CI: 1.32–3.95, p = 0.003), whereas the independent protective predictor was normal hemoglobin (HR: 0.88, 95% CI: 0.78–0.98, p = 0.022).ConclusionsIn this real-world registry cohort of ACS patients treated with PCI and 1 year of DAPT in Spain, we report a trend of increased rate of MACE and new revascularization not associated with TVR in patients with longer DAPT. Our findings support the need for future randomized controlled trials to confirm or refute these results.