bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-organ single-cell RNA-sequencing reveals early hyperglycaemia responses that converge on fibroblast dysregulation
Authors: Braithwaite Adam T. , Akbar Naveed , Pezzolla Daniela , Paget Daan , Krausgruber Thomas , Bock Christoph , Carnicer Ricardo , Choudhury Robin P. 
Published: August 2023

AbstractDiabetes causes a range of complications that can affect multiple organs. Hyperglycaemia is an important driver of diabetes-associated complications, mediated by biological processes such as dysfunction of endothelial cells, fibrosis and alterations in leukocyte number and function. Here, we dissected the transcriptional response of key cell types to hyperglycaemia across multiple tissues using single-cell RNA-seq (scRNA-seq) and identified conserved, as well as organ-specific, changes associated with diabetes complications. By studying an early timepoint of diabetes, we focus on biological processes involved in the initiation of the disease, before the later organ-specific manifestations had supervened. We used a mouse model of type 1 diabetes and performed scRNA-seq on cells isolated from the heart, kidney, liver and spleen of streptozotocin-treated and control mice after 8 weeks and assessed differences in cell abundance, gene expression, pathway activation and cell signalling across organs and within organs. In response to hyperglycaemia, endothelial cells, macrophages and monocytes displayed organ-specific transcriptional responses, whereas fibroblasts showed similar responses across organs, exhibiting a myofibroblast-like phenotype with altered metabolic gene expression and increased differentiation of myeloid-derived fibroblasts. Further, we found evidence of endothelial dysfunction in the kidney, and of endothelial to mesenchymal transition in streptozotocin-treated mouse organs. In summary, our study represents the first single-cell and multi-organ analysis of early dysfunction in type 1 diabetes-associated hyperglycaemia, and our large-scale dataset (comprising 67,611 cells) will serve as a starting point, reference atlas, and resource for further investigating the events leading to early diabetic disease.
New machine learning method identifies subtle fine-scale genetic stratification in diverse populations
Authors: Qin Xinghu , Jia Peilin 
Published: August 2023

AbstractFine-scale genetic structure impacts genetic risk predictions and furthers the understanding of the demography of populations. Current approaches (e.g., PCA, DAPC, t-SNE, and UMAP) either produce coarse and ambiguous cluster divisions or fail to preserve the correct genetic distance between populations. We proposed a new machine learning algorithm named ALFDA. ALFDA considers both local and global genetic affinity between individuals and also preserves the multimodal structure within populations. ALFDA outperformed the existing approaches in identifying fine-scale genetic structure and in retaining population geogenetic distance, providing a valuable tool for geographic ancestry inference as well as correction for spatial stratification in population health studies.
The spectrum of inter-organizational relationships and social capital mobilization of MNEs
Authors: Castro-Abancéns Ignacio , Casanueva Cristóbal , Gallego Ángeles 
Published: August 2023

PurposeMultinational enterprises (MNEs) establish a wide range of alliances to access the critical resources that they may need at any one time. Although inter-organizational relationships (IORs) constitute the channels through which social capital flows, MNEs should consider which mechanisms or characteristics of the relations facilitate their actual mobilization.Design/methodology/approachA definition of alliance types yielded the parameters for an ordinary least squares regression of a sample from top global-reach MNEs from the airline industry.FindingsThe results showed that certain kind of alliances favored the actual mobilization of social capital.Practical implicationsManagers of MNEs must select the type of IOR taking into account the objective they pursue and the type of activity they will include.Originality/valueAnalyzing the factors that influence the degree of mobilization of social capital and how MNEs actually use the resources of the partners require the establishment of a theoretical framework and the development of empirical evidence.
Co-creation of business and marketing models for SMEs in short food supply chains in Lithuania, Latvia and Poland
Authors: Oleksiuk Adam , Rull Quesada Katarzyna 
Published: August 2023

Purpose The aim of this article is to identify the issues of short food supply chains (SFSCs) in three countries of Central and Eastern Europe, i.e. Lithuania, Latvia and Poland, to compare the barriers to shortening food supply chains and to indicate business models for short supply chains.Design/methodology/approach Within the AgroBRIDGES project, the authors organized local co-creation workshops from August to September 2021 in 12 European regions and countries, engaging 150+ agrifood stakeholders of the project’s local communities.Findings The development potential of SFSCs in Lithuania, Latvia and Poland is high and seems to be growing every year. Currently, the development potential of SFSCs in Lithuania, Latvia and Poland is stimulated more by social trends than by public support. Traditional business models based on the distribution of food products through local and regional markets have a definitely diminishing potential.Research limitations/implications Although this article covers an existing gap in the literature, it also has several limitations that may serve as an inspiration for future research. First, the results draw on a sample of agrifood value chain stakeholders in Lithuania, Latvia and Poland; hence, the findings might be industry specific. Therefore, future studies should explore this topic on wider target groups or different industries. Moreover, the method is qualitative and could be supplemented with additional quantitative analysis of similar tools or the experience of other agrifood companies from European countries.Practical implications The article seeks to build bridges between consumers and producers by supporting SFSCs through a systemic, holistic and multi-actor approach.Originality/value The study elaborates on the under-researched topic of SFSCs in the context of barriers to shortening food supply chains and business models for short supply chains in Lithuania, Latvia and Poland.
How do resource scarcity reminders influence consumers’ CSR engagement?
Authors: Ye Tian , Mattila Anna S. 
Published: August 2023

Purpose
This study aims to understand consumers' reactions to hospitality corporate social responsibility (CSR) campaigns under different resource scarcity reminders, an important but overlooked contextual factor, and examine how such scarcity reminders interact with message framing, a widely used technique in CSR communication.

Design/methodology/approach
Three experimental studies were conducted. Studies 1 and 2 examined the main effect of resource scarcity reminders (environmental vs personal) on consumer engagement via self-other orientation. Study 3 further investigated the interactive effect between resource scarcity reminders (environmental vs personal) and message framing (gain vs loss) with hope as a key mediator.

Findings
Studies 1 and 2 show that environmental (vs personal) scarcity activates a more salient other orientation, subsequently increasing consumers' donation and word-of-mouth intentions. Study 3 reveals that environmental (vs personal) scarcity makes people more hopeful with gain-framed messages. Moreover, the elevated hope enhances perceived efficacy (attitude toward the company), leading to higher donation (word-of-mouth) intention.

Practical implications
Hospitality marketers could remind consumers of the harsh environment to elicit other orientation and encourage CSR participation. Using gain-framed messages or other hope-inducing appeals would be particularly advantageous in engaging consumers in CSR campaigns during heightened environmental scarcity.

Originality/value
Focusing on consumer responses to CSR campaigns, to the best of the authors’ knowledge, this research is the first to reveal reminders of resource scarcity as a novel antecedent factor and further uncover how such reminders interact with message framing to affect CSR engagement.
Can trust in management help? Job satisfaction, healthy lifestyle, and turnover intentions
Authors: Gopalan Neena , Beutell Nicholas J. , Alstete Jeffrey W. 
Published: August 2023

PurposeThis study assesses the role of trust in management on relationships between predictors (supervisor support, coworker support and meaningful work) and outcomes (job satisfaction, turnover intentions and healthy lifestyle).Design/methodology/approachData from 1,302 working adults from the National Survey of Changing Workforce was used in this study. Structural equation models and mediation analyses are used to analyze the data.FindingsFindings indicate that trust in management significantly mediates relationships between support (supervisor, coworker) and outcomes and meaningful work and outcomes. Trust in management does not mediate relationships involving turnover intentions. Gender does not have a significant impact on the findings.Practical implicationsThis study shows how trust in management is increasingly important during disruptions including high levels of voluntary turnover known as the Great Resignation. Trust in management is a key factor in work involvement and organizational citizenship behaviors.Originality/valueThis novel study tests how trust mediates relationships between both organizational behavior factors and work factors in relation to outcomes. The importance of developing and sustaining trust in management is paramount because it affects work-related outcomes as well as an individual's job satisfaction and healthy lifestyle.
Board of directors’ attributes and capital structure: evidence from Pakistani-listed non-financial firms
Authors: Ur Rahman Shams , Khalil Afef , Cavaliere Luigi Pio Leonardo , Ben Khelifa Soumaya 
Published: August 2023

PurposeThis study aims to explore the effect of the board of directors on the capital structure of listed non-financial firms on the Pakistan Stock Exchange (PSX).Design/methodology/approachUsing a panel data set of 208 financial Pakistani enterprises from 2015 to 2020, regression analysis is employed to examine the data utilizing independent variables such as board size, outside directors, directors' remuneration and managerial ownership to evaluate board characteristics and the total debt ratio for capital structure.FindingsThe results show that the board size positively impacts the debt ratio. However, outside directors, directors' remuneration and managerial ownership are negatively connected with the capital structure. The empirical findings indicate that corporate governance mechanisms play an important role in the capital structure decision of Pakistani non-financial companies.Practical implicationsThis research contributes to the literature by addressing the function of the board of directors in the governance of Pakistani enterprises.Originality/valueFew studies in Pakistan focus on board characteristics and those that do utilize different variables. This research aims to fill a critical gap by investigating the effect of the board of directors' attributes and the capital structure of the listed non-financial sector of Pakistan.
Perceived innovation-oriented human resource system and innovative work behavior: the chain mediating role of innovative culture and intrinsic motivation
Authors: Xu Zhihua , Yang Fu , Yuan Yingjie , Jia Dan 
Published: August 2023

PurposeThis study investigated the effect of individual perceptions of innovation-oriented human resource system (IHRS) on individual innovative work behavior (IWB) and how this effect is realized.Design/methodology/approachThe authors conducted an online questionnaire survey at three time points with 481 employees in three Chinese organizations. Structural equation modeling was used to test the hypothesized relationships among the variables.FindingsPerceived IHRS was found to positively influence IWB, and this effect was sequentially mediated by individual perceptions of innovative culture and intrinsic motivation.Practical implicationsIn order to elicit IWB, HR systems should be constructed around the strategic objective of innovation. Moreover, there should be a match between IHRS and innovative culture to trigger intrinsic motivation and ultimately IWB.Originality/valueThis study examines the effect of perceptions of IHRS on individuals' IWBs; Moreover, it integrates organizational culture and individual motivation and finds a chain mediating role of individual perceptions of innovative culture and intrinsic motivation in the relationship between IHRS and IWB.
Richness and dynamics: how to improve virtual reality tourism adoption with virtual social clues
Authors: Zhu Jiaji , Jiang Yushi , Wang Yedi , Yang Qiang , Li Wei 
Published: August 2023

PurposeTourism via virtual reality (VR) technology has become an interesting option for consumers to “travel.” The best approaches to optimizing the VR tourism environment, improving the interactive experience of tourists and encouraging tourists to adopt VR are not yet fully understood. This study explores the willingness of tourists to adopt VR tourism from the dual aspects, richness and dynamics, of virtual social cues.Design/methodology/approachTo examine the effects of richness (multiple vs. few cues) and dynamic (changeable vs. static cues) on consumers' willingness to adopt VR tourism, three virtual tourism scenes were designed and presented by head-mounted displays. The data were collected for participants in the VR laboratory and tested by ANOVA and partial least squares–structural equation modeling.FindingsVirtual social cues can generate mental imagery through interactivity, vividness and parasocial interactions, thus increasing the consumer's likelihood of adopting VR tourism. It was also found that imagination moderates mental imagery and adoption intention. When the consumer's imagination is stronger, their mental imagery stimulates a stronger willingness to adopt VR tourism.Originality/valueThe authors innovatively utilize concepts of parasocial interaction and mental imagery and discuss the various influences and mediation mechanisms of social cue characteristics on consumers' adoption of VR tourism. The conclusions may provide new insights for VR tourism managers and tourism scholars.
Adoption of professional indemnity insurance among estate surveying and valuation firms in Oyo State, Nigeria
Authors: Ekpo Immaculata Anthony , Oladokun Timothy Tunde 
Published: August 2023

PurposeErrors or negligence are inherent parts of professional services, thus necessitating the adoption of professional indemnity insurance (PII) as a risk management tool to protect professional interest. This paper sought to examine the adoption of PII among Estate Surveying and Valuation firms in Oyo State, Nigeria.Design/methodology/approachThe quantitative research methodology was adopted, and primary data were collected via questionnaires distributed to 84 purposively selected Estate Surveyors and Valuers (ESVs) who are mostly principal partners or branch managers in the study area. Sixty-three questionnaires representing 75.0% were returned and found useable. Data collected were analysed with the aid of descriptive statistics of percentages and relative importance index (RII).FindingsThe study found that the influence of foreign investors as well as the requirements of PII by the professional body as a basis for annual license renewal were responsible for higher level of awareness among the practitioners. However, about average of the firms had adopted PII with few taking professional insurance policy of as low as ₦500,000 per annum. The study recommends that NIESV/ESVARBON should sensitize, monitor and enforce the adoption of PII by ESVs as a means to increase public confidence and credibility of valuers while rendering professional services to clients.Research limitations/implicationsThe current study was limited in coverage to Ibadan thus necessitating a study with wider area of coverage of national status.Practical implicationsThe study has major implications on real estate education and practice in Nigeria. There is an urgent need for the professional body to devise means of enforcing compliance with the adoption of PII so as to be able to get the confidence of their teeming clients for subsequent patronage.Originality/valueThe paper is one among the scanty studies that provides a useful guide to real estate practitioners in developing countries towards adopting PII to shield the company from unnecessary negative exposure and financial loss.
Sovereignty at what price? Existential displacement at the Lebanese/Syrian border
Authors: Obeid Michelle 
Published: August 2023

AbstractIn 2014, Islamist jihadist groups overran a Lebanese border town and besieged it for four days, spreading terror across the town and the country as a whole. In response, the Lebanese army launched a violent counterattack on these groups with the aid of Hizbullah in what became known as the Battle of Arsal. Declaring the area a security zone, the army restricted mobility and placed Lebanese citizens and Syrian refugees under military confinement. While the battle ended with a government‐declared victory that celebrated the ‘reclamation of state sovereignty’, these events disrupted social life in unprecedented ways. This article focuses on the phenomenological experience of sovereignty and the price paid for the desire for this state. I explore the ruptures people experienced in theirexistence(their right to life, subsistence, and movement under indiscriminate shelling) andexistentiality(their reflections on their human existence in time, place, and relationship to others in a social world that is no longer recognizable). I argue for a concept ofexistential displacementthat focuses on the experience of citizens as well as refugees for a broader understanding of the ruptures and dispossessions taking place in conflict.
Where Does I Stand? Reflections on Home and Identity Ensnared in a Cultural Narrative
Authors: de Waal Joanna 
Published: August 2023

AbstractIn this paper the author explores a cultural narrative that she suggests rests on the concepts of the Feminine and Masculine as such, employing both as though they contain an agreed set of universal givens. These givens are extrapolated from an androcentric perspective on female and male bodies, in particular their biological functions regarding reproduction. The metaphors of the baby‐in‐womb, mother’s preoccupation with child and heteronormative sexual relations are the primary cyphers for the narrative. She suggests that remaining unconscious of this narrative, such that it is taken as a universal given, can hamper a person’s relation to themselves, the world and others. The author names two concepts, Home and Identity: Home being an hospitable and accommodating space with Identity denoting the one who inhabits the space. In the narrative these two are unhelpfully categorized as belonging to the Feminine and the Masculine respectively. For ease of understanding the author uses a capital letter to designate an abstract idea, and lower case when referring to the concrete or particular. Clinical examples are given throughout the paper to illustrate how acknowledgement and awareness of this narrative might free the analyst or therapist to think more broadly around issues pertaining to space and identity.
New microbial tools to boost restoration and soil organic matter
Authors: Sáez‐Sandino Tadeo , Delgado‐Baquerizo Manuel , Egidi Eleonora , Singh Brajesh K. 
Published: August 2023

AbstractAnthropogenic activities are causing unprecedented rates of soil and ecosystem degradation, and the current restoration practices take decades and are prone to high rates of failure. Here we propose, the development and application of emerging microbiome tools that can potentially improve the contents and diversity of soil organic matters, enhancing the efficacy and consistency of restoration outcomes.
Recognising symptoms of congenital myasthenic syndromes in children: A guide for paediatricians
Authors: Orriëns Lynn B. , Eker Dilan , Braakman Hilde M. H. , Merkus Peter J. F. M. , Erasmus Corrie E. 
Published: August 2023

AbstractAimCongenital myasthenic syndromes (CMS) are a rare and diverse group of treatable neuromuscular transmission disorders. Diagnosis is often substantially delayed. This study aimed to identify common symptoms of CMS in children and their manifestation to aid diagnosis and early intervention.MethodsWe performed a retrospective cohort study, including 18 children (median age 13 years, range 9 years 5 months–18 years 0 month) with CMS. Data on CMS symptoms and their manifestation were extracted from patients' charts and supplemented with parental telephone interviews. Descriptive analyses were used to identify common symptoms.ResultsA median diagnostic delay of 4 years and 7 months (interquartile range: 51 months) was observed. Proximal muscle weakness (100%), ptosis (89%), clumsy gait (82%), difficulty eating solid foods (78%) and recurrent respiratory tract infections (72%) were most common in these patients. Symptoms mostly co‐occurred and frequently had a fluctuating character, aggravated by infections or fatigue.ConclusionEarly referral to diagnose CMS is crucial to enable timely initiation of treatment. Heightened attention to a combination of symptoms related to muscle weakness, rather than individual symptoms, should support paediatricians in flagging these neuromuscular disorders. Medical history taking should be tailored to parents' perceptions, asking questions about recognisable symptoms of muscle weakness.
What is known about midwives' well‐being and resilience? An integrative review of the international literature
Authors: Moran Lynnelle , Foster Kim , Bayes Sara 
Published: August 2023

AbstractBackgroundInternationally, the midwifery workforce is facing a professional crisis due to numerous organizational and individual factors that have led to midwives leaving the profession. These factors include high levels of workplace stress, systemic barriers to providing woman and person‐centered care, trauma, and burnout. The COVID‐19 pandemic magnified these pre‐existing stressors and adversities and has further disrupted midwives' ability to practice within their professional norms. In order to understand how midwives can be better supported, there is a need to understand what contributes to and detracts from their well‐being and resilience.AimTo investigate and synthesize the extant international knowledge on midwives' well‐being and resilience in the context of workplace stress and adversity.MethodIntegrative review of the literature published in peer‐reviewed journals.ResultsThematic analysis of the literature resulted in three core themes: (1) risk factors and adversity; (2) protective factors and resilience; and (3) sustaining factors and well‐being in midwifery. Findings from this integrated review highlight that several factors associated with workplace adversity can also be sources of protection depending on their presence or absence. Within the included studies, there exists a broad use of concepts and definitions that are applied to well‐being and resilience, resulting in a lack of uniformity and cohesion.ConclusionsIn this review, we identified a high level of workplace adversity and the subsequent impacts on midwives' well‐being and resilience. A series of protective factors and strategies that can be used to improve the well‐being of midwives and support resilience within the profession were also identified; however, further research of the population is required. In addition, the development of cohesive well‐being and resilience concepts specific to midwifery is recommended, as is the development and application of uniform terminologies and definitions.