bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Methods for Cutting Pressure Retained Cores from Deep Unconventional Reservoirs in West Kuwait - First Ever Successful Pressure Coring Operation in the Najmah Kerogen
Authors: Ekpe J. , Al-Shehab A. Y. , Al-Othman A. , Baijal S. , Nguyen K. L. , Al-Morakhi R. , Dasma M. , Al-Mutairi N. , Verma N. , Quttainah R. B. , Janem M. , Deutrich T. , Wunsch D. , Rothenwänder T. , Anders E. , Mukherjee P. 
Published: May 2023

Abstract
The successful recovery of pressurized core samples from an unconventional HPHT reservoir is presented. Optimized methods and technologies such as implementation of Managed Pressure Drilling (MPD) technique as well as coring technology customization and adaptation are discussed. Results from offset wells are compared and a best practice method is described how to recover pressurized cores from the organic rich Najmah Kerogen in West Kuwait.
A coring BHA was configured using a modified version of the LPC Core Barrel hence allowing for the first time to consider recovering pressurized core samples from a well with a very challenging operating envelope. Furthermore, the provided methodology ensures that well conditions are maintained to allow for a pressurized core recovery in most stable wellbore environment avoiding any unwanted subsurface problems.
With three consecutive runs planned on for the pressurized coring using MPD each 10 ft., the results obtained showed a successful coring operation of which typical wellbore downhole issues were avoided with no loss time due to well ballooning, mud losses and well kicks. The successful coring operations as well as all subsequent on-site analysis procedures showed possibility to recover pressurized core samples from unconventional formations with high formation pressure in a safe and effective manner. Avoiding core damage due to petal-centerline fractures and disking is fundamental in quantifying natural fractures in this unconventional reservoir.
This novelty approach of core barrel system modification and using MPD technique in acquiring the pressurized cores has made it possible to obtain representative near in-situ data to better reservoir interpretation and quantification of natural fractures. The method has a great potential to ensure high core recovery in high angle wells while delivering superior reservoir fluid and rock information which is not obtainable by other means.
Operational Experience from the Implementation of 21 Wells with Non-Metallic Based Downhole Tubing: From Pilot to Large Scale Implementation
Authors: Ahmad M.H. 
Published: May 2023

Abstract
Tubular GRE lining technology has been globally applied used since 1960's in eliminating downhole tubular corrosion, replacing the elevated CAPEX of CRA OCTG and assuring steady oil, gas and water flow through the downhole string with its flow assurance benefits.
Compared to conventional carbon steel whose failures are frequent, the GRE lined carbon steel provides long lasting protection which results in huge savings in life cycle cost. Likewise, compared to CRA material capable of withstanding corrosion issues, the GRE lined CS provides direct capital cost savings. Apart from the economic benefits, operators deploying GRE lined CS have enjoyed superior well integrity over the life cycle of the well.
Abu Dhabi National Oil Company (ADNOC ONSHORE) implemented this technology in 2013 for the water disposal wells (5 wells as trial, all of them were successful). We will share the results of the caliper logs that have been run into these wells and the inspection of tubing pulled out of the disposal wells after 4 years in service. Following the assessment, which was satisfactory, the first Water Injection well with GRE lined tubing has been RIH in 2021, and plans for Oil producers with GRE lined tubing in Q2-2023.
Till the time of writing this paper, 19 GRE lined strings have been RIH in Aon's water disposal wells, and 2 strings have been run in water injection wells (under study and field test and assessment).
This paper shares the evolution of this technology within the Aon from the first installation to the development of a contract and how Aon geared to absorb this technology in their system. Some of the challenges that faced the company were: The modifications that were required to the wells’ designs.How the service provider was aware of Aon's operational well intervention jobs.How this is compatible with the lining system.
Longest Slim Hole ERD Wells Campaign with Limited Entry Liner Using Water-Based Mud in Onshore Abu Dhabi
Authors: Varma Esha Narendra , Ditzler Theodore Jay , Mwansa Peter Levison , Husien Mohammad , Bahrom Abdul Raman Bin , Saragi Raymond , Samahi Musabbeh Khamis Al , Shamsi Juma Sulaiman Al , Alshaigy Ahmad Othman , Gaurav Anchit , Abdelhalim Khaled 
Published: May 2023

Abstract
Extended reach drilling (ERD) can facilitate the development of untapped resources, reduce greenhouse gas emissions, surface congestion, and drilling costs. This ERD project with lower completion was started with an aim to lower well cost indicators including $/ft and $/bbl. Therefore, the challenge was to drill Slimhole ERD (6-1/8″ lateral) wells with water-based mud (WBM). WBM is more cost-effective, environmentally friendly, and less damaging to the reservoir than OBM (oil-based mud). The use of WBM instead of OBM can save $2MM per well. The major challenges in drilling Slimhole (6-1/8″ size) ERD well with lateral le include higher torque and failure to deploy lower completion due to high friction factors.
The first pilot well was planned with a liner-less design considering the low friction factors required to drill 15,000′ of 6-1/8″ lateral hole and run the lower completion. The second pilot well was targeting a deeper and tighter reservoir zone with higher downhole temperatures. This involved drilling 12-1/4″ intermediate hole to the landing point with larger 5-1/2″ drill pipe. It enabled a push-pipe technique for drilling the lateral hole with improved weight transfer through the curved profile. The 6-1/8″ lateral hole was drilled with 4″ high-torque drill pipe, tandem high-flow circulating subs, and specially formulated drilling fluid lubricant. A conventional OBM system provides sufficient lubricity to reduce friction factors as low as 0.10. In this application, a low cost WBM system was made feasible by introducing stable high-temperature lubricant and unique hole cleaning practices.
Following this successful achievement, the 5-year business plan has been revised to include 63 similar wells with a projected total savings of ~ $250MM.
The Slimhole ERD project has demonstrated substantial value with a 35% reduction in CAPEX. The delivery of these two Slimhole ERD wells overturned conventional drilling and completion practices.
The implemented project resulted in saving up to 35% of the well cost and saved 20 days per well compared to a conventional ERD well with 8-1/2″ hole and OBM. These two Slimhole ERD (15,000′ lateral) wells were drilled with a challenging Directional Difficulty Index (DDI) of 7.2. The wells were both completed successfully by running the 4-1/2″ lower completion to reach the total depth.
Protocol for Pre and Post-Operative Voice therapy (PaPOV) for benign vocal fold lesions: Non-randomised, multicentre feasibility trial with nested process evaluation
Authors: White Anna , Carding Paul , Booth Vicky , McGlashan Julian , Stan Jarrad Van , Logan Pip , Awad Rehab 
Published: May 2023

Abstract
Background:
Management of benign vocal fold lesions (BVFLs) is variable with some receiving surgery, voice therapy or a combination of these approaches. Some evidence suggests that the best outcomes may be achieved when patients are offered pre and post-operative voice therapy in addition to phonosurgery, but what constitutes pre and post-operative voice therapy is poorly described. The pre and post-operative voice therapy (PaPOV) intervention has been developed and described according to the TiDIER checklist and Rehabilitation Treatment Specification System for voice. The PaPOV intervention is delivered by specialist speech and language therapists trained in the intervention and comprises 7 essential and 4 additional components, delivered in voice therapy sessions with patients who are having surgery on their vocal folds for removal of BVFLs.
Study Design:
Non-randomised, multicentre feasibility trial with embedded process evaluation
Method:
40 patients from two sites who are due to undergo phonosurgery will be recruited to receive the PaPOV intervention. Measures of feasibility, including recruitment, retention, and adherence will be assessed. The feasibility of gathering clinical and cost effectiveness data will be measured pre treatment, then at 3 and 6 months post-operatively. An embedded process evaluation will be undertaken to explain feasibility findings.
Discussion:
This study will assess the feasibility of delivering a described voice therapy intervention protocol to patients who are undergoing surgery for removal of benign vocal fold lesions (BVFLs). Findings will be used to inform the development and implementation of a subsequent effectiveness trial, should this be feasible.
TRIAL REGISTRATION
This trial has been prospectively registered on ISRCTN, (date 4th January 2023), registration number 17438192 and can be viewed here: https://www.isrctn.com/ISRCTN17438192
Landslide Susceptibility Mapping of Phewa Watershed, Kaski, Nepal
Authors: Kunwar Bimal Bahadur , Muensit Nantakan , Techato Kuaanan , Gyawali Saroj 
Published: May 2023

Abstract
The objective of this study was to assess the quantities of association between landslide events and causal factors in order to generate an accurate, updated landslide susceptibility map (LSM) of the Phewa watershed in Kaski, Gandaki District, Nepal. Landslides are the second-largest natural disasters of the world, and the costs of their damage could be more than those of all other multi-hazard disasters together. Nepal receives a lot of rain, especially during the monsoon season, which creates a number of water-induced risks each year, such as landslides. The LSM, which allows for effective landslide risk prediction. The most dependable and popular statistical approach for determining LSMs is the frequency ratio (FR) model. In ArcGIS 10.8, the LSM was created using eight causal factors. Five classes were represented in the LSM, with the low class having a large percentage (43.226%) and the high class having a low percentage (0.63%). In FR techniques, slope, proximity to a stream or road, land use/cover, precipitation, and proximity to a road are given greater weight than aspect, profile curvature, and plan curvature, which are given comparably less weight in this study area. Using the area under the curve (AUC), the model's performance was validated, and the performance was good, 0.71. The information given by this LSM, which provided the spatial distribution of the landslide and help to reduce landslide risk issues in the Phewa watershed, can be useful to researchers, communities, planners, and the government.
Physical, chemical and microbiological attributes as discriminators of coffee and forest areas under different soils in the Brazilian Atlantic Forest biome
Authors: Aragão Osnar Obede da Silva , Jesus Ederson da Conceição , de Oliveira-Longatti Silvia Maria , Souza André Alves , Moreira Fatima Maria de Souza 
Published: May 2023

Abstract
Ensuring soil quality of coffee fields is fundamental for sustainable production of coffee itself. Microbiological attributes are especially effective predictors of changes in the soil. But their value as indicators can vary depending on the soil class and the type the management. This study aimed to determine the effect of different soil classes and management (natural systems and agricultural systems) on microbiological attributes and the potential of these attributes to serve as discriminators of different soils used for conventional coffee growing in the Atlantic Forest domain. The microbial biomass carbon (MBC), microbial basal respiration (MBR), the metabolic quotient (qCO2), microbial quotient, and the activity of several enzymes were assessed in coffee plantations and adjacent forests on two soil classes. The lowest values of most attributes were observed in the Planosol under a coffee plantation. The activities of most of the enzymes were higher in the forest’s Oxisol and lower in the Planosol under coffee. Among the physical and chemical attributes, organic matter content, potential acidity, potential cation exchange capacity, pH, phosphorus, and zinc were most important in the discrimination of the areas. For the microbiological attributes, the forest vegetation maintained higher MBC, BMR, qCO2, and urease activity independent of soil class. Nevertheless, the soil class had a marked negative effect on microbial biomass and activity in the Planosol coffee plantation. We can conclude that MBC, FDA, urease, β-glucosidase, and acid phosphatase were the most important attributes in the discrimination of coffee and forest areas under different soil classes.
Class II HLA-DRB4 is a predictive biomarker for survival following immunotherapy in metastatic non-small cell lung cancer
Authors: Jiang Cindy Y. , Zhao Lili , Green Michael D. , Ravishankar Shashidhar , Towlerton Andrea M. H. , Scott Anthony J. , Raghavan Malini , Cusick Matthew F. , Warren Edus H. , Ramnath Nithya 
Published: May 2023

Abstract
Immune checkpoint inhibitors (ICI) are important treatment options for metastatic non-small cell lung cancer (NSCLC). However, not all patients benefit from ICIs and can experience immune related adverse events (irAEs). Limited understanding exists for germline determinants of ICI efficacy and toxicity, but human leukocyte antigen (HLA) has emerged as a potential predictive biomarker. We obtained HLA genotypes from 85 metastatic NSCLC patients on ICI therapy and analyzed the impact of HLA Class II genotype on progression free survival (PFS), overall survival (OS), and irAEs. Most patients received pembrolizumab (83.5%). HLA-DRB4 correlated with improved survival in both univariable (PFS 9.9 months, p = 0.040; OS 26.3 months, p = 0.0085) and multivariable analysis (PFS p = 0.0310, HR 0.55, 95% CI [0.31, 0.95]); OS p = 0.003, HR 0.40, 95% CI [0.21, 0.73]). 11 patients developed endocrine irAEs. HLA-DRB4 was expressed in 39/85 (45.9%) patients and was the predominant genotype for endocrine irAEs (9/11, 81.8%). Cumulative incidence of endocrine irAEs was higher in patients with HLA-DRB4 (p = 0.0139). Our study is the first to suggest metastatic NSCLC patients on ICI therapy with HLA-DRB4 genotype experienced improved survival outcomes. Additionally, we found a correlation between HLA-DRB4 and endocrine irAEs.
How does urban-rural integrated medical insurance affect labour supply of migrant workers
Authors: Zhou Deshui , Jin Wenhui , Wu Hainan 
Published: May 2023

Abstract
Based on the dynamic monitoring survey data of the floating population in 2018, this study analyses the impact of urban and rural integrated medical insurance on the labour supply of migrant workers. The study found that this medical insurance significantly promoted the labour participation rate of migrant workers and improved the quality of labour supply. Using instrumental variables to solve endogenous and propensity score matching method to solve selective bias, this study’s results are robust. Regarding the stability of labour supply, urban and rural integrated medical insurance has significantly increased the probability of migrant workers obtaining fixed income jobs and reduced the probability of them engaging in non-fixed income jobs. Further analysis shows that it has significantly reduced the working time of migrant workers, and improved the accessibility of their health rights and interests through health records, health education, and family contracted doctor services, which are important factors to improve the labour supply of migrant workers.
DUSP6 regulates NOTCH1 signaling in colorectal cancer
Authors: Png Chin Wen , Weerasooriya Madhushanee , Hou Xiaowen , Teo Yaxuan Fiona , Zheng Ser , Sobota Radoslaw , Chong Choon Seng , Tan Ker-Kan , Zhang Yongliang 
Published: May 2023

Abstract

Notch1 plays various roles in cancer development and Notch1-induced transactivation is controlled by phosphorylation of its cleaved intracellular domain. However, if there are phosphatases that are able to dephosphorylate cleaved Notch1 intracellular domain (NICD) to regulate its function is unclear. Here we showed that DUSP6 is a Notch1 phosphatase which regulates NICD stability hence transcriptional activity, thereby regulating colorectal cancer (CRC) development. It was found that high tumoral DUSP6 protein expression is associated with poorer overall CRC patient survival. In human CRC cells, increased DUSP6 expression is associated with increased NICD level resulting in more CRC cell proliferation in both in vitro and in vivo. Development of CRC upon induction was reduced in mice deficient in DUSP6. Mechanistically, DUSP6 dephosphorylates phospho-Y2116 to reduce NICD ubiquitination that in turn increases NICD stability and transcriptional activity. Consequently, Notch1-targeted proliferation gene expression is increased to promote tumour cell growth.
Evaluation of Aluminum Effects to Freshwater Planarian Dugesia tigrina (Girard, 1850)
Authors: Braguini WELLIGTON LUCIANO 
Published: May 2023

Abstract
The toxicity and reproductive effects of aluminum to freshwater worm Dugesia tigrina were investigated by LC50 (96h) evaluation, locomotor activity (pLmV), glycogen content, reproductive effects (fertility and fecundity). The results revealed an LC50 (96 h) of 348.08 µM Al. Planarian mobility reduced by 74.6% with 100 µM Al, and glycogen content were reduced by 34.3% at 150 µM Al. Fecundity and fertility were reduced by 47.8 and 67.8%, respectively, in planarians treated with 50 µM Al (pH 7.0). The number of cocoons was reduced by 100% with 50 µM Al (pH 5.9). The time until hatching was extended by 24.8% for planarian cocoons incubated in 50 µM Al at pH 7.0. The data showed that the acidic environment generated by the AlCl3 solubilization, and Al itself, cause toxicity in planarians. The presence of Al in effluents or water from rivers and lakes is a silent contaminant for aquatic animals because it changes the pH of the water. Notwithstanding the impact of Al on other species and environments, it is necessary to establish methods for meaningful and responsible environmental management of Al waste rolled out into the environment. The results provide a comprehensive evaluation of the toxicological effects that aluminum has on flatworms and aquatic environment.
Evaluating the economic disparities in the world: Sentiment Analysis on Central Bank Speeches from Third World and First World Countries
Authors: Vazirani Krish 
Published: May 2023

Abstract

This paper provides an evaluation of the financial and simple sentiment of central bank speeches from 2004–2019. The speeches are categorized into two different sub-groups with three different countries for each one, respectively: Zambia, Barbados, and Sri Lanka for the third world [developing] group and France, Canada, and Japan for the first world [developed] group. This paper attempts to answer the following questions: (i) What do the sentiments of each country or sub-group tell us about their economic condition? (ii) How does the sentiment relate to the countries' contextual economic growth or decline? (iii) How do the central or federal banks of the country portray the economy? Using natural-language processing, more specifically BERT transformer models and modern NLP methods, a synthesized evaluation is created of what economic linguistics from central banks can reveal about the world's economy.
Impact of multimodal strategy on sepsis bundle compliance and in- hospital mortality in patients with hematologic malignancies
Authors: Silva Luciane Luz e , Ferreira Diogo Boldim , Melillo Karina Prandi , Passos Roselene Mesquita Augusto , Medeiros Eduardo Alexandrino 
Published: May 2023

Abstract
Introduction: Sepsis is one of the leading causes of mortality in patients with hematologic malignancies. Our aim is evaluate the impact of multimodal strategy on sepsis bundle compliance and in-hospital mortality in patients with hematologic malignancies.
Methods:We conducted a quasi-experimental study that included patients with hematologic malignancies and sepsis or septic shock, between January 1, 2017 and August 31, 2020. The study comprised two phases: phase 1, survey of sepsis and sepsis shock cases and reformulation of the sepsis team and sepsis bundle; phase 2, staff training, monthly meetings of the sepsis team and feedback for care teams. The followup of patients was for 30 days, during hospitalization, or until death. Data were analyzed with descriptive and inferential statistics, with a 95% significance interval. And the tests considered a 5% significance level.
Results: A total of 329 (42.5%) patients were included. The proportion of sepsis was 241 (73.3%) and septic shock 88 (26.7%). We observed an increase in the 3h-bundle compliance in the phase 2 (86.8%), compared to the phase 1 (71.3%), with p=0.001. The in-hospital mortality was lower in the 2nd phase (38.2%), compared to the first phase (51.5%), with p=0.024. These results were mainly observed in cases of sepsis identified in the wards.
Conclusions:The multimodal strategy had an impact on increasing the rate of compliance to the sepsis bundle. In-hospital mortality significantly reduced in the intervention phase of the study.
Examining Micro and Small Enterprises from a Gender Perspective in Urban Cambodia
Authors: Rahut Dil , Aryal Jeetendra Prakash , Chhay Panharoth , Morgan Peter 
Published: May 2023

Abstract
Micro and small enterprises (MSEs) provide livelihood opportunities for a large population, especially for the poor. Participation in MSEs depends on the individuals’ and households’ financial, human, physical, natural, and social capitals. As the literature on developing countries has found that men and women have differential access to and ownership of productive resources, this study uses the Cambodia Socio-Economic Survey 2019–2020 to examine factors influencing participation in MSEs and the associated gender differences in urban Cambodia. The current study’s findings suggest that assets, education, and access to credit are crucial drivers of participation in MSEs. Applying Blinder–Oaxaca decomposition showed a gender gap in MSE participation, with women owning more MSEs than men. However, the differences in participation vary across sectors. While women have higher participation rates in retail and wholesale, restaurants, and smaller enterprises, men are more likely to participate in manufacturing, construction, and repairs. Another crucial finding of this study is that a large proportion of men- owned enterprises fall under the petty trading categories (i.e., the lowest stratum of the MSEs), indicating that gender policies also need to consider poorer and less skilled sections of society. Government policies to promote the development of MSEs should focus on two aspects: (i) skills training to enable women to also be equally able to participate in manufacturing, construction, and repairs sectors; and (ii) improved access to credit, so both men and women can participate in enterprises requiring bigger investments.