bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved T staging diagnosis and outcome prediction of prostate cancer using genomic LASSO model
Authors: Lei Mingde , zhang Mingpeng , Chen Xueqiao , Yang Yanjie , Li Qi , Shang Zhiqun 
Published: March 2023

Abstract
As one of the most diagnosed malignancies in men, prostate cancer has exhibited a high incidence rate in recent years. According to the NCCN guidelines, TNM staging of prostate cancer is an important basis for the best treatment modality. Here in this study, we established two model systems for PCa's T staging diagnosis and disease-free prediction for the first time, based on the combined analysis of WGCNA, univariate COX, and LASSO regression. Models for T staging and disease-free exhibited a high accuracy of 81.3% and 77.5% in the validation cohort, respectively. In addition, a significant negative correlation between gene expression and DNA methylation was observed in these models, which may provide new insight for further studies. Overall, our research can assist clinical diagnosis, predict the disease-free survival of patients, guide the choice of treatment options, and provide new ideas for the studies of prostate cancer.
Stability of arthroscopic modified suture bridge fixation for displaced large greater tuberosity fractures
Authors: Kim Min Woo , Lee Dong Ha , Noh Young Min , Yoo Jae Heung 
Published: March 2023

Abstract
Purpose
Arthroscopic fixation of GT avulsion fractures via suture bridge repair has been described in several articles. We describe a technique for large, displaced GT fracture fixation using arthroscopy only, without any metal fixation. This study evaluated clinical outcomes and demonstrated mechanical stability of arthroscopic suture bridge fixation for displaced large greater tuberosity (GT) fractures.
Study Design
Case Series (retrospective), Level 4
Methods
This study retrospectively reviewed 9 cases of isolated large, displaced GT fractures that were treated via arthroscopic suture bridge fixation and could be followed up for more than 2 years in our hospital between March 2017 and January 2019.
Demographic characteristics, clinical characteristics, including range of motion (ROM), visual analog scale (VAS) score, American Shoulder and Elbow Surgeons (ASES) shoulder score, and UCLA score, were analyzed retrospectively. Two radiological parameters were set to verify the stability of suture bride fixation on large fragments. Parameter A was the distance between the lateral border of the GT fragment and the humeral shaft. Parameter B was the distance between two parallel lines starting from the center of the humeral head and the GT tip perpendicular to the humerus axis. By comparing these parameters between the immediate postoperative X-ray and the last follow-up X-ray, we evaluated the stability of reduction.
Results
The mean follow-up time was 30.9 months (range, 25–47 months), and the average age was 60.7 years (range, 26–79 years). By the final follow-up, the VAS score improved from 8.7 to 1.8 (range, 1–3 points). The American Shoulder and Elbow Surgeons score improved to 93 (range, 86.5–98.5) and the mean UCLA score improved to 31.67 (range, 27–34) postoperatively. The mean forward flexion was 160.0°(range, 120°–170°), mean abduction was 150.0°(range, 110°–170°), and mean external rotation was 77.8°(range, 60°–90°). Mean internal rotation improved to nearly T12(range, T9-L5).
Radiologically, follow-up radiologic evaluation showed that bony union was achieved within 8 to 12 weeks in all cases. Comparing immediate postoperative anteroposterior X-ray with last follow-up radiograph, the difference in parameter A was 0.84 mm on average, and the difference in parameter B was 1.01 mm on average, which showed significant stability of reduction (p > 0.05).
Conclusion
Arthroscopic suture bridge fixation for isolated, even large fragmentary GT fractures can be a good option, as it allows for solid fixation and identifying of concomitant pathologies such as Bankart lesions and rotator cuff tears.
Explanation of Impact Resistance of Materials with the Help of Specific Energy Absorption Capability (SEAC)
Authors: BARUK Muhammed Bahri , AYTAÇ Ayhan 
Published: March 2023

Abstract

The impact resistance of materials is a significant criterion for material designs. The impact resistance can be tested in the areas of use of the materials as well as measured by impact tests in the laboratory environment.
In this study, a test material was designed by placing 10 different materials, mainly alumina and steel ball, between two plates based on Al 5083.
10 J of energy was applied to one side of the designed test material with a drop-weight tester, and from the other side, the output forces were measured with a dynamometer. In the experiments, the input forces were measured using a drop-weight tester and the output forces were measured using a dynamometer placed on the back surface.
To make the forces applied to the front of the material more stable, the impact tests were repeated under the same conditions by placing a polymer material on the front surface, and the tests were modeled using the abaqus program.
The test results of the polymer and non-polymer design were compared with the numerical modeling results, and as a result of the study, the Specific Energy Absorption Capability (SEAC) model was created to explain the energy absorbtion ability of the materials.
Efficacy of Computer-assisted Robotic–based clinical training program for spinal oncology education on pedicle screw placement
Authors: Wang pengru , Xin Yingye , Zhou Shangbin , Zhao Jian , Duan Shujie , Zhu Zhipeng , Yuan Hao , Bai Danyang , Li Bo , Xu Wei 
Published: March 2023

Abstract
Background: Accurate pedicle screw placement is one of the fundamental surgical techniques for novice orthopedists in spinal oncology education. So, we set forth to establish a computer-assisted robotic navigation training program for spinal oncology education. Novice orthopedists and patients are involved in this study to evaluate the feasibility and safety of the computer-assisted robotic navigation (CARN) training program.
Methods: In this research, 2 trainees were randomly taught by the CARN training program and the traditional training program. We prospectively collected clinical data from 1st May 2021 to 1st March 2022 in 45 patients with spinal tumors, including the time of PSP, serving as primary outcomes, the accuracy of the pedicle screw, and other clinical data. Then the ability of PSP was evaluated by cumulative sum (CUSUM) analysis, learning curve, and accuracy of pedicle screws.
Results: The patients included in both groups had similar baseline characteristics. 169 pedicle screws in the CARN group and 179 pedicle screws in the traditional group were evaluated in our research. In the CUSUM analysis of the learning curve for the time of PSP, the turning point in the CARN group (70th pedicle screw) was less than the one in the traditional group (92nd pedicle screw). The LC-CUSUM test signaled competency for PSP at the 121st pedicle screw in the CARN group, while 138th in the traditional group. Then the accuracy of pedicle screws showed that the rate of grade A in the Gertzbein-Robbins classification was significantly higher in the CARN group than in the traditional group (88.17% and 79.55%, P=0.03 <0.05). Furthermore, no major complications occurred in both groups.
Conclusion: We firstly described computer-assisted robotic navigation in spinal oncology education. We also indicated the CARN training program as a novel education method, and an efficient and safe surgical training program in spine surgery.
Compliance with antibiotic therapy guidelines in French pediatric intensive care units (COMITY study)
Authors: Amadieu Romain , Brehin Camille , Chahine Adéla , Grouteau Erick , Dubois Damien , Munzer Caroline , Brissaud Olivier , Ros Barbara , Jean Gael , Brotelande Camille , Travert Brendan , Savy Nadia , Boeuf Benoit , Ghostine Ghida , Popov Isabelle , Duport Pauline , Wolff Richard , Maurice Laure , Dauger Stephane , Breinig Sophie 
Published: March 2023

Abstract
Background: Bacterial infections (BIs) are widespread in ICU. The aims of this study were to assess the compliance with antibiotic recommendations, and factors associated with non-compliance.
Methods: We conducted an observational study in eight French Pediatric and Neonatal ICUs with an antimicrobial stewardship program mostly once a week. All children receiving antibiotics for a suspected or proven BI were evaluated. Newborns <72 hours old, neonates <37 weeks, age ≥18 years, and antibiotic for prophylaxis were excluded.
Results: 139 suspected (or proven) BI episodes in 134 children were prospectively included during six separate time-periods over one year. The final diagnosis was 26.6% no bacterial infection, 40.3% presumed bacterial infection, and 35.3% documented bacterial infection. Non-compliance for all parameters occurred in 51.1%, with errors mainly concerning the antimicrobials’ choice (27.3%), duration of each antimicrobial (26.3%), and duration of antibiotic therapy (18.0%). In multivariate analysis, main independent risk factors of non-compliance were prescribing ≥2 antibiotics (OR 4.06, 95% CI 1.69-9.74, p=0.0017), a duration of broad-spectrum antibiotic therapy ≥4 days (OR 2.59, 95% CI 1.16-5.78, p=0.0199), suspecting catheter-related bacteremia (ORs 3.70 and 5.42, 95% CIs 1.32 to 15.07, p<0.02), a BI site with no clear treatment guidelines (ORs 3.29 and 15.88, 95% CIs 1.16 to 104.76, p<0.03), and ≥1 risk factor for ESBL Enterobacteriaceae (OR 2.56, 95% CI 1.07-6.14, p=0.0353). Main independent factors of compliance were having antibiotic therapy protocols (OR 0.42, 95% CI 0.19-0.92, p=0.0313), respiratory failure (OR 0.36, 95% CI 0.14-0.90, p=0.0281), and aspiration pneumonia (OR 0.37, 95% CI 0.14-0.99, p=0.0486).
Conclusions: Half of antibiotic prescriptions remain non-compliant with guidelines. Intensivists should daily reassess the benefit of using several or broad-spectrum antimicrobials and stop antibiotics that are no longer indicated. Developing consensus about treating specific illnesses and using service protocols seem necessary to reduce errors. A daily ASP could also improve compliance in these error-prone situations.
Trial registration: This trial was approved by Toulouse University Hospital, and is registered in its register of data study, number RnIPH2019-79, and with ClinicalTrials.gov, number NCT04642560. The date of first trial registration in ClinicalTrials.gov was 24/11/2020.
Risk prediction in carotid stenosis with time dependency of high-impact variables and multiple endpoint analysis
Authors: Hervik Kjersti , Wilsgaard Tom , Myrmel Truls , Kjørstad Knut Eivind 
Published: March 2023

Abstract
Electronic patient records represent a potential data source for the future, as digital free text extraction by artificial intelligence is coming closer to safe options for handling of confidential information. Big data from patient records could in turn be applied to improve risk prediction for several disease groups. In this project, a pilot dataset based on information from patient journals was collected to explore the suitability of free text information in risk prediction for patients with carotid stenosis. 863 patients with the ICD-10 diagnosis carotid stenosis were included, and the risk of stroke was analysed in relation to treatment and variables previously shown to impact disease progression or stroke risk. Variables previously shown to have a strong impact on this risk were included with time dependency, to allow analysis of trends in risk in relation to changes in risk profile over time. Multiple endpoint analysis was performed to explore the excess risk in patients who suffered more than one event. Results from the suggested model were compared to results from traditional cox regression, and concordance analysis was performed to compare these two models. In analysis of the pilot dataset, the expanded model with time dependency and multiple endpoint analysis appears to provide a better model fit then a traditional cox regression analysis performed on the same dataset.
SP1/CTR1 mediated oxidative stress-induced cuproptosis in intervertebral disk degeneration
Authors: Peng Yizhong , Chen Xuanzuo , Li Kanglu , Xiao Yan , Wu Wei , Lin Hui , Qing Xiangcheng , Tian Shuo , Liu Sheng , Wang Baichuan , Shao Zengwu 
Published: March 2023

Abstract
Intervertebral disk degeneration (IDD) is the primary pathology responsible for lower back pain. Oxidative stress-induced cell death plays a fundamental role in IDD pathogenesis. Cuproptosis is a recently discovered form of programmed cell death dependent on copper availability. Whether cuproptosis is involved in IDD progression remains unknown. Herein, we established in vitro and in vivo models to investigate the presence of cuproptosis in IDD and the mechanisms by which oxidative stress interacts with copper sensitivity in nucleus pulposus cells (NPCs). We found that expression of the key cuproptosis regulator ferrodoxin-1 (FDX1) increased with disk degeneration in both rat and human disks. Sublethal oxidative stress on NPCs led to increased FDX1 expression and cell death in the presence of Cu2+ at physiological concentrations, whereas knockdown of FDX1 inhibited cell death. Since copper homeostasis is involved in copper-induced cytotoxicity, we investigated the role of copper transport-related proteins, including importers (transporter copper transporter 1 [CTR1] ) and efflux pumps (ATPase transporter, ATP7A, and ATP7B). We found that expression of CTR1 and ATP7A increased under oxidative stress, and blocking CTR1 significantly reduced oxidative stress/copper-induced cell death. Moreover, we found that oxidative stress promoted the expression of specific protein 1 (SP1) and SP1-mediated CTR1 transcription. SP1 inhibition improved cell viability and decreased cell death rates, which was reversed by the administration of elesclomol, a copper ionophore. Importantly, SP1 inhibition both significantly preserved disk hydration and alleviated tissue degeneration. This suggest that oxidative stress mediates cuproptosis by increasing copper flux through the promotion of SP1-mediated CTR1 transcription. This study highlights the importance of cuproptosis in IDD progression and provides a promising therapeutic target for IDD treatment.
Weight loss and mortality in people living with HIV: a systematic review and meta-analysis
Authors: Cordeiro Sarah Almeida , Lopes Tainá Costa Pereira , Boechat Antonio Luiz , Gonçalves Roberta Lins 
Published: March 2023

Abstract
This project was designed to evaluate whether people living with HIV (PLHIV) on HAART, hospitalized, with weight loss, have higher mortality than those hospitalized using HAART and without weight loss. It was a meta-analysis of prospective cohort studies published in English, Spanish or Portuguese. We searched MedLine, Embase, and LILACS and conducted the report according to MOOSE. We analyzed methodological quality and risk of bias by the Joanna Briggs Institute's Critical Assessment Tool for Cohort Studies, used the risk ratio (RR) to calculate the probability of hospitalized PLHIV who lost weight evolve to death, applied the random effect model, and created the funnel chart. Ten of the 670 studies identified were included for analysis, with a total of 1,637 PLHIV. We used the inverse test of variances estimated by the Mantel-Haenszel method, considering a 95% confidence interval, heterogeneity (I2), total effect size (Z), and a significance value of p < 0.05. The risk of hospitalized PLHIV who lost weight dying was 1.5 times greater than that of hospitalized PLHIV who did not lose weight (RR: 1.50, 95% CI: 1.03, 2.19, p = 0.04). We conclude that weight is still a determinant of mortality in PLHIV, even those on HAART. Prospero registration number: CRD42020191246
Novel multiredox π-conjugated perimidine polymers with
ultra-low band gap
Authors: Lapkowski Mieczyslaw , Janasik Patryk , Chulkin Pavel , Czichy Malgorzata 
Published: March 2023

Abstract
The electropolymerization of prepared monomers 1 (mixture of perimidino[1',2':1,5]pyrrolo[3,4-m]phthaloperine-9,19-dione and 17H,19H-perimidino[1',2':1,2]pyrrolo[3,4-m]phthaloperine-17,19-dione) and 2 (benzo[lmn]diperimidino[2,1-b:2',1'-i][3,8]phenanthroline-10,21-dione and benzo[lmn]diperimidino[2,1-b:1',2'-j][3,8]phenanthroline-18,21-dione) resulted in the synthesis of electroactive conductive materials with structures similar to fused perinone dyes. Polymer p1 was obtained via the electropolymerization of monomer 1 with low yield and low stability, which was insufficient for further analysis. However, fundamental perinone polymer p2, containing a perimidinobenzophenanthroline skeleton, which was obtained by electropolymerization of 2, where its thickness and structure could be controlled in a one-step electrochemical process. This novel poly(perimidinobenzophenanthroline) polymer was electrically conductive and displayed a complex redox activity, mixed conductivity, and an ultra-low band gap of 0.14 eV. The regular D-A structure and specific intermolecular interactions also played a role in its characteristics. The mechanism of the electrooxidation process, which led to the formation of protonated, semi-ladder, and ladder bis-perimidine segments in polymers, was proposed using electrochemical analysis and quantum-chemical calculations.
How to Compare Muscle Strength More Appropriately: A Methodological Systematic Review of Cognitive Studies in Older Adults
Authors: Lin Ting-Yu , Tsai Yu-Jung , Hung Tsung-Min 
Published: March 2023

Abstract
Objectives
This methodological systematic review aims to determine how previous studies have underestimated the relationship between muscle strength and cognitive performance, record the number of such studies, provide recommendations for future studies, and propose potential methods by which to reanalyze the data from previous studies.
Methods
A systematic search was performed using PubMed and Scopus. Studies were included if (1) they were cross-sectional or cohort (prospective and retrospective) studies that investigated the relationship between cognitive performance and muscle strength and (2) the mean age of the participants was ≥ 50 years.
Results
After the titles and abstracts of 1,800 articles were screened, 127 articles were successfully retrieved and their full texts were screened. Finally, 77 studies were included in the review. We classified muscle strength metrics into five categories: (1) absolute strength, (2) absolute strength adjusted for body mass index (BMI), (3) relative strength (absolute strength ÷ body weight), (4) allometric strength (absolute strength ÷ body weight0.67), and (5) muscle quality (absolute strength ÷ muscle cross-sectional area). The first three metrics are problematic because absolute strength, regardless of adjustment for BMI, is positively correlated with body weight and relative strength is negatively correlated with body weight. Only allometric strength and muscle quality were considered suitable metrics for comparing muscle strength across individuals. In 76 out of 77 studies (99%), the strength of the relationship between muscle strength and cognitive function was underestimated because of a lack of or improper adjustment for body weight.
Discussion
We conclude that 99% of previous studies failed to appropriately adjust for participants’ body weight. Therefore, we provide two recommendations. First, allometric strength, rather than absolute or relative strength, should be used to compare participants. Second, for studies that use the repetition-to-fatigue method (testing how many repetitions a participant can complete with a given weight), such as arm curl tests, the use of a prediction formula to calculate the one-repetition maximum is recommended.
Registration
This study was registered with the International Prospective Register of Systematic Reviews (PROSPERO ID: CRD42021271356).
The use of Sentinel 2 to quantify N, Ca, and K in walnut orchards
Authors: Mendes Maria Beatriz , Farinha Daniela , Barroso João Mota , Rato Luís Miguel , Sousa Adélia , Rato Ana Elisa 
Published: March 2023

Abstract
'Persian walnut' (Juglans regia L.) is one of the most consumed nut species in the world, and N, K, and Ca nutrition are critical for its growth and quality. Mineral nutrition management in fruit crops over large areas is a challenging task only possible with a remote sensing data approach and using rapid analytical methods to correlate remotely sensed data with ground data. In the present study, predictive models to quantify N, Ca, and K were developed based on remote sensing data from the Sentinel-2 satellite (9 different spectral bands and 2 vegetation indices (NDVI and NDWI)) using a multiple linear regression approach. The predictive models for N, Ca and K were satisfactory, with R2 values of 0.72, 0.61 and 0.79, respectively. Therefore, the results obtained indicate that remote sensing is a potential technology to assess the nutrient status in crops in a faster and more reliable way than traditional plant leaf analysis procedures.
The use of contracts as a form of private regulation to implement and manage healthy vending: best practice recommendations for effective and sustained interventions
Authors: Dancey Jane , Reeve Belinda , Jones Alexandra , Brimblecombe Julie 
Published: March 2023

AbstractBackground:Private regulation, such as contracts, can be an effective lever to implement and manage health-enabling food retail environments. However, guidance for the effective use of contracts in food retail settings is limited. The use of contracts to create healthy foodvendingenvironments is one area where policy attention has been focussed. We applied a public health regulatory framework to publicly available guidance documents on healthy vending to develop best practice recommendations for using contracts to create healthy food vending environments.Methods:Document analysis involved i) snowball sampling to identify eligible publicly available healthy vending guidance documents from an identified seed paper; ii) application of a public health regulatory framework to extract data across three domains of form, substance and governance of healthy vending initiatives; and iii) synthesis of data to form best practice recommendations. Eligible documents were those aimed at implementing healthier vending; published from 2000 onwards; accessible online; and included recommendations beyond nutrition standards alone, including a reference to at least one regulatory governance process (administration, implementation, monitoring, enforcement or review).Results:Twelve of 92 documents identified were eligible and all were from the United States (US). All noted that products need to comply with nutrition standards. Other aspects of regulatory substance (i.e., pricing, promotion, placement, labelling and contract length) were less well considered as were elements of regulatory governance (regulatory rules, administration, implementation, monitoring, enforcement and review). Our adapted framework covers three regulatory domains with nine components, and a further 20 recommendations for best practice application in healthy vending.Conclusions:To be effective, contracts used to manage healthy food vending should include more than the nutrition standards for healthy food and drinks. Clearly stating the regulatory objectives, operative terms and conditions, and defining responsibilities for monitoring, review and enforcement within the contract, in addition to the nutrition standards, will assist practitioners in creating effective and sustained contract-based initiatives aimed at improving the healthiness of vending, or other food retail environments.