bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic literature review identifying bacterial constituents in the core intestinal microbiome of rainbow trout (Oncorhynchus mykiss)
Authors: Hines Ian S. , Marshall Maggie A. , Smith Stephen A. , Kuhn David D. , Stevens Ann M. 
Published: August 2023

AbstractFish aquaculture has become the fastest growing sector in global food production. Thus, ensuring the sustainability of aquaculture practices is of the utmost importance. Studies in higher vertebrates (i.e. mammals) have demonstrated the role of the host microbiome in physiological processes from nutrient acquisition to pathogen protection. Therefore, analysis of fish microbiomes is an important factor to consider with regard to overall animal health and welfare. Rainbow trout (Oncorhynchus mykiss) are an economically valued fish cultured worldwide. Several studies have identified microbial constituents inhabiting the intestinal tract of rainbow trout. To better elucidate some of the core constituents of the rainbow trout intestinal microbiome, this systematic literature review analysed the relative abundance results from 25 articles published on the rainbow trout intestinal microbiome from 2017 to 2021. Bacteria classified within the phyla Firmicutes and Proteobacteria were observed in every study. At the family level, Lactobacillaceae was consistently observed. Additionally, bacteria in the Actinobacteria, Bacteroides, and Tenericutes phyla were identified in at least 50% of the studies. Interestingly, Mycoplasma spp. were occasionally the most dominant organisms present in the microbiome. Overall, the results here identify bacteria that are commonly found members of the rainbow trout intestinal microbiome.
A novel pathogenic variant c.262delA in PBX1 causing oligomeganephronia identified using whole‐exome sequencing and a literature review
Authors: Hu Jiaxin , Yang Huihui , Wang Xiaowen , Ding Juanjuan , Liao Panli , Zhu Gaohong , Qi Chang 
Published: August 2023

AbstractOligomeganephronia (OMN) is a rare congenital renal hypoplasia reported more often in children than in adults. The diagnosis of OMN relies on renal biopsy and exhibits a significant reduction in the number of glomeruli and pronounced glomerular hypertrophy. Here, we report the case of an 8‐year‐old boy with recurrent proteinuria and abnormal external ears. A renal biopsy revealed large and rare glomeruli. The histological findings confirmed the diagnosis of OMN. Whole‐exome sequencing of the patient revealed a new pathogenic variant in PBX1 (hg19, NM_002585, c.262delA, p.Thr88Glnfs*3). The PBX1 gene encodes a transcription factor whose pathogenic variants can result in congenital renal and urinary system anomalies, with or without hearing loss, abnormal ears, and developmental retardation (CAKUTED). This is the first report to detect PBX1 pathogenic variants in children with OMN, a novel phenotype of human PBX1 pathogenic variants. We performed functional prediction analyses of deletions in the corresponding structural domains. We summarized 27 cases of PBX1 single pathogenic variants reported between 2003 and 2023 in terms of truncating and missense pathogenic variants, which can deepen our understanding of the PBX1 structural domain and expand our knowledge of the PBX1 genotype and phenotype.
Erweiterung des Reaktionsspektrums: Nachweis des 5‐Deazaflavin‐Radikals durch photochemisch induzierte dynamische Kernpolarisation
Authors: Wörner Jakob , Panter Sabrina , Illarionov Boris , Bacher Adelbert , Fischer Markus , Weber Stefan 
Published: August 2023

AbstractDeazaflavine sind wichtige Analoga der natürlich vorkommenden Flavine, Riboflavin, Flavinmononukleotid (FMN) und Flavin‐Adenin‐Dinukleotid (FAD). Durch Austausch des natürlichen Kofaktors mit dem entsprechenden 5‐Deazaflavin konnten in einer Reihe von Flavoproteinen wichtige Erkenntnisse zum Reaktionsmechanismus gewonnen sowie deren Reaktivität beeinflusst werden. Es wurde häufig beobachtet, dass Ein‐Elektronentransfer‐Reaktionen in Flavoproteinen mit 5‐Deazaflavin als Kofaktor eingeschränkt sind. Hieraus wurde gefolgert, dass der im Vergleich mit dem entsprechenden Flavinsemichinon geringeren Stabilität des 5‐Deazaflavin‐Radikals rasch ablaufende Reoxidations‐ und Disproportionierungsreaktionen zugrunde liegen. Das vermeintliche Paradigma, wonach 5‐Deazaflavin lediglich als Zwei‐Elektronen‐ bzw. Hydrid‐Akzeptor/Donor fungiert, sozusagen ein “nicotinamide in flavin clothing” darstellt, muss nun durch die unter biologisch relevanten Reaktionsbedingungen erfolgte indirekte Beobachtung einer einfach reduzierten (paramagnetischen) Spezies mit Hilfe der 1H‐photo‐CIDNP‐NMR (photo‐CIDNP: photo‐chemisch induzierte dynamische Kernpolarisation) neu bewertet werden.
Expanding Reaction Horizons: Evidence of the 5‐Deazaflavin Radical Through Photochemically Induced Dynamic Nuclear Polarization
Authors: Wörner Jakob , Panter Sabrina , Illarionov Boris , Bacher Adelbert , Fischer Markus , Weber Stefan 
Published: August 2023

AbstractDeazaflavins are important analogues of the naturally occurring flavins: riboflavin, flavin mononucleotide (FMN), and flavin adenine dinucleotide (FAD). The use of 5‐deazaflavin as a replacement coenzyme in a number of flavoproteins has proven particularly valuable in unraveling and manipulating their reaction mechanisms. It was frequently reported that one‐electron‐transfer reactions in flavoproteins are impeded with 5‐deazaflavin as the cofactor. Based on these findings, it was concluded that the 5‐deazaflavin radical is significantly less stable compared to the respective flavin semiquinone and quickly re‐oxidizes or undergoes disproportionation. The long‐standing paradigm of 5‐deazaflavin being solely a two‐electron/hydride acceptor/donor—“a nicotinamide in flavin clothing”—needs to be re‐evaluated now with the indirect observation of a one‐electron‐reduced (paramagnetic) species using photochemically induced dynamic nuclear polarization (photo‐CIDNP) 1H nuclear magnetic resonance (NMR) under biologically relevant conditions.
Micromechanical analysis of age‐induced strength reduction in a multiaxially loaded short‐fiber reinforced thermoplastic
Authors: Wismans Martijn , van den Broek Sten J. J. , van Breemen Lambèrt C. A. , Govaert Leon E. , Engels Tom A. P. 
Published: August 2023

AbstractIn this study, we demonstrate that the strength of a short‐fiber reinforced polymer as measured in uniaxial tension is not a good indicator for its strength under multiaxial loading conditions. To illustrate this fact, the influence of physical aging on the strength of a 20 wt% short‐fiber reinforced polycarbonate is studied for a uniaxial and biaxial loading condition. Results demonstrate that aging strongly reduces the strength in multiaxial loading, whereas, it increases in uniaxial loading. To rationalize these observations, a micromechanical analysis of the local stress state is performed using three‐dimensional (3D) representative volume elements (RVE) in combination with a constitutive model that adequately describes the intrinsic deformation response of the matrix. RVE simulations demonstrate that biaxial loading results in higher local hydrostatic stresses and triaxiality than the uniaxial loadcase for the composite system considered, and aging results in a shift towards higher values. The high triaxiality, the magnitude of the hydrostatic stress, and the shift in hydrostatic stress upon aging, presents a clear rationalization why physical aging induces a strength reduction in biaxial loading and not in uniaxial loading. These results highlight that care should be taken when predicting strength under complex loading conditions with only uniaxial data available.
Study on damping and self‐healing properties of polyurethane materials based on dynamic synergetic control of disulfide bond and imine bond
Authors: Dong Guangchao , Chang Yuanzhi , Li Cangang , Zhao Lifen , Tian Xiujuan , Liu Xueping 
Published: August 2023

AbstractPolyurethane is a widely used viscoelastic polymer known for its exceptional damping properties. This paper focuses on the introduction of disulfide and imine bonds into the polyurethane matrix to enhance its damping capabilities, mechanical properties, and self‐healing ability. Dynamic mechanical analysis shows that the synergistic effect of disulfide bond and imine bonds extends the effective damping temperature range of the polyurethane to 118°C (−18 to 100°C), while the effective damping frequency extrapolates to a range of 10−2–105 Hz. Furthermore, the addition of imide bonds compensates for the relatively low mechanical properties associated with disulfide bonds, allowing the polyurethane to achieve a tensile strength of 14.7 MPa at room temperature. Self‐repair tests reveal that the combined action of these two dynamic bonds enables a remarkable 97% repair efficiency of polyurethane, exhibiting excellent self‐healing performance. This study presents a novel approach to enhance the comprehensive properties of polyurethane.
Poly(vinyl alcohol) antibacterial films containing cross‐linked chitosan‐citric and photosensitive curcumin
Authors: Kong Dexin , Wei Wenguang , Zhi Xiujuan , Du Bin , Chen Xiangning 
Published: August 2023

AbstractComposite films PVA‐CS‐Curx (x = 0, 0.01, 0.06 and 0.12%) were successfully obtained by using vacuum‐drying at 80°C. The occurrence of nonenzymatic browning and cross‐linking of chitosan‐citric improved the thermal stability, water‐resistance, and mechanical property of films. Under the same humidity, the oxygen permeability of PVA‐CS‐Curx showed the dependence of test temperature and curcumin concentration (P < 0.05). Relative to other films, the oxygen permeability (10−14 cc μm cm−2 s−1 Pa−1) of PVA‐CS‐Cur0.12 was 3.47 ± 0.55, 4.72 ± 0.94, and 7.29 ± 0.45 at 23, 30, and 40°C, respectively, showing gentle upward trend as temperature increased. Under white light irradiation, excellent antibacterial capability of PVA‐CS‐Curx demonstrated that polycationic chitosan‐citric complex and curcumin immobilized in films played the roles as synergistic antibacterial agents. Upon white irradiation of 20 min at 60 mW cm−2, the bactericidal rate of PVA‐CS‐Cur0.12 reached to 94.0 ± 3.09%. The excellent decontamination in meat preservation endowed films with the possibility in application of food decontamination.
Equity market performance: The role of environmental protection and corporate social responsibility efforts
Authors: Panda Anupriya , Ray Koustubh Kanti 
Published: August 2023

AbstractBusinesses that contribute to social welfare and development are regarded as reliable and generate more wealth for their stakeholders. This study attempts to determine how corporate social responsibility (CSR) and environmental protection measures influence the financial performance of Indian businesses. A panel dataset containing 330 Nifty 500 companies is included to determine their relationship. The quarterly and semi‐annual share prices are employed as proxies for the financial performance of companies. In the regression model, the lagged share prices (log) of two periods serve as the response variable, while the CSR and the CSR plus the environment and pollution control expenses (CSREP) serve as explanatory variables. The results suggest that the fixed‐effect regression model is suitable where the explanatory variables are time‐invariant and the relationship between the dependent and explanatory variables across firms is constant over time. Our analysis indicates that CSR spending alone has little effect on the share prices of companies over two prospective time periods. However, as companies invest more in environmental and pollution control activities in addition to their CSR expenditure, the market recognises this as a significant factor, and their share prices rise. Consequently, we discovered that CSREP (CSR plus environmental and pollution control expenditure) is a significant factor that influences quarterly and semi‐annual share prices.
Common institutional ownership and green innovation in family businesses: Evidence from China
Authors: Ding Hao 
Published: August 2023

AbstractGiven the ubiquity of family businesses and the growing importance of ecological sustainability, it is crucial to promote family businesses to carry out green innovation activities and enhance their green innovation capability. In recent years, the prevalence of common institutional ownership in capital markets has attracted the attention of the academic community. Drawing on socioemotional wealth theory and strategic reference point theory, this paper tries to explore the impact of common institutional ownership on green innovation in family businesses. Using data from Chinese‐listed family businesses from 2009 to 2021, this paper finds that common institutional ownership can facilitate green innovation in family businesses. The higher the degree of their linkage and the greater the shareholding, the more pronounced the synergistic effect. The findings remained valid after considering the endogeneity issue and conducting robustness tests. The mechanism test suggests that common institutional ownership enhances green innovation in family businesses by improving the internal control quality and reducing financing constraints. This paper contributes to the study of how to effectively facilitate green innovation in family businesses by identifying the common institutional ownership from the perspective of external governance mechanisms. In addition, this paper enriches the research on the economic consequences of common institutional ownership. Finally, various practical implications for family businesses and policymakers may be realized, which may help family businesses to enhance their green innovation capabilities and contribute to the green transformation of society.
Sustainable development barriers and pressures in SMEs: The mediating effect of management commitment to environmental practices
Authors: Madrid‐Guijarro Antonia , Duréndez Antonio 
Published: August 2023

AbstractThere is a broad consensus about Small and Medium‐sized Enterprises' (SMEs) responsibility for global pollution, resource consumption, and waste generation. However, numerous researchers have identified a research gap in the context of SMEs' managerial and operational environmental insights. Concretely, this gap involves management commitment, the drivers and barriers to sustainability, and their impact on SMEs' environmental performance. This study, grounded on the institutional, stakeholder, and upper echelon theories, fills this gap. We test our hypotheses using a quantitative empirical approach with structural equation modeling on a dataset of 351 SMEs. Our findings show the key role of management commitment to environmental performance in SMEs since it exerts a positive mediating effect on the relationship between the drivers of sustainability and environmental performance. Based on the Upper Echelon Theory, results demonstrate the relevance of the mediating effect of management commitment (values, skills, and attitudes) to encourage sustainable business models of SMEs in order to reduce pollution, emissions, energy consumption, and noise, as well as promote the development of sustainable products and facilities.
Airway management and quadratus lumborum block for inguinal hernia repair in context of chromosome 4q deletion: A case report
Authors: Lovell Katie , Larkins Michael C. , Pasli Melisa , Hutton Adrienne L. 
Published: August 2023

Key Clinical MessageChromosome 4q Deletion Syndrome (4QDS) is a rare chromosomal deletion that presents with various congenital defects that could affect anesthetic management. We present a patient with known 4QDS who underwent successful general anesthetic induction, tracheal intubation, and subsequently, bilateral quadratus lumborum nerve blocks, during laparoscopic inguinal hernia repair surgery.AbstractChromosome 4q deletion syndrome (4QDS) is a rare chromosomal deletion with the potential for congenital defects that could affect the anesthetic management of affected patients, specifically with inconsistent reports of possible laryngeal narrowing which could precipitate intubation difficulties. We present a report of a patient with known 4QDS who underwent successful general anesthetic induction and tracheal intubation, followed by subsequent bilateral quadratus lumborum nerve blocks, in the context of laparoscopic inguinal hernia repair surgery. Given the inconsistent presentation of patients with 4QDS reported in the literature, steps were taken to exercise sufficient caution concerning the overall management of this patient per the most recent guidelines for pediatric patients.
Visible‐Light‐Irradiated Multicomponent Reactions of Aliphatic Amines, Propiolate Acid Esters, and CF3SO2Na for Accessing β‐CF3 Enamines
Authors: Tang Yisong , Huang Mingyang , Jiang Liang , Zhang Xiaotong , Zheng Shaojun , Yang Yong , Chen Xiao Yun 
Published: August 2023

AbstractA novel one‐pot two‐step multicomponent reaction has been achieved for the preparation of β‐CF3 enamines by using different aliphatic amines, propiolates, and CF3SO2Na as starting material. In this protocol, various aliphatic amines including primary amines, cyclic or acyclic secondary amines were demonstrated to be good coupling partners, and different β‐CF3 enamines were obtained in moderate to good yields. Among them, the primary aliphatic amines only gave pure (E)‐β‐CF3 enamines as products. The synthetic utility of the MCRs strategy was further demonstrated by mild conditions, gram‐scale synthesis and natural sunlight‐induced protocol. Preliminary mechanistic studies suggest that this trifluoromethylation of C(sp2)−H involves radical process.
Tau, ADNP, and sex
Authors: Gozes Illana 
Published: August 2023

AbstractWith 50 years to the original discovery of Tau, I gave here my perspective, looking through the prism of activity‐dependent neuroprotective protein (ADNP), and the influence of sex. My starting point was vasoactive intestinal peptide (VIP), a regulator of ADNP. I then moved to the original discovery of ADNP and its active neuroprotective site, NAP, drug candidate, davunetide. Tau–ADNP–NAP interactions were then explained with emphasis on sex and future translational medicine.
A generalization of Geroch's conjecture
Authors: Brendle Simon , Hirsch Sven , Johne Florian 
Published: August 2023

AbstractThe Theorem of Bonnet–Myers implies that manifolds with topology do not admit a metric of positive Ricci curvature, while the resolution of Geroch's conjecture implies that the torus does not admit a metric of positive scalar curvature. In this work we introduce a new notion of curvature interpolating between Ricci and scalar curvature (so‐calledm‐intermediate curvature), and use stable weighted slicings to show that for and the manifolds do not admit a metric of positivem‐intermediate curvature.
Molecular Ruthenium Cyclopentadienone Bifunctional Catalysts for the Conversion of Sugar Platforms to Hydrogen
Authors: Messori Alessandro , Martelli Giulia , Piazzi Andrea , Basile Francesco , De Maron Jacopo , Fasolini Andrea , Mazzoni Rita 
Published: August 2023

AbstractMolecular ruthenium cyclopentadienone complexes were employed for the first time as pre‐catalysts in the homogeneously catalysed Aqueous Phase Reforming (APR) of glucose. Shvo's complex resulted the best pre‐catalyst (loading 2 mol %) with H2 yields up to 28.9 % at 150 °C. Studies of the final mixture allowed to identify the catalyst's resting state as a mononuclear dicarbonyl complex in the extracted organic fraction. In situ NMR experiments and HPLC analyses on the aqueous fraction gave awareness of the presence of sorbitol, fructose, 5‐hydroxymethylfurfural and furfural as final fate or intermediates in the transformations under APR conditions. These results were summarized in a proposed mechanism, with particular emphasis on the steps where hydrogen was obtained as the product. Benzoquinone positively affected the catalyst activation when employed as an equimolar additive.
Microwave‐assisted synthesis of novel steroidal heterocyclic analogs as potent inhibitors of RANKL‐induced osteoclastogenesis
Authors: Elmasry Ghada F. , Ali Roaa A. , El‐kady Dina S. , El‐Moghazy Samir M. , Elmegeed Gamal A. , Tantawy Mohamed A. 
Published: August 2023

AbstractOsteoporosis is a significant public health issue in our aging population. It is an excessive bone resorption condition brought on by osteoclastogenesis, which makes bones more brittle. In the present work, a series of novel heterosteroidal derivatives have been synthesized using the microwave technique and were evaluated as antiosteoclastogenic agents. The structures of the newly synthesized compounds have been confirmed using analytical and spectral data. The antiosteoclastogenic activity of the newly synthesized compounds was estimated in vitro against osteoclast‐differentiated cells from the RAW 264.7 cell line. The pregnenolone dimer 10, the pyridinotestosterone derivative 2, and the phenylnicotinonitrile pregnenolone derivative 8a attained the most promising antiosteoclastogenic activity displaying IC50 (the half maximal inhibitory concentration) values of 5.45 ± 5.30, 11.88 ± 2.09, and 13.40 ± 3.00 µM, respectively, in comparison with dimethyl itaconate (IC50 = 17.76 ± 3.20 µM) and alendronate (IC50 = 4.48 ± 1.89 µM) as reference compounds. Finally, an in silico ADME (Absorption, Distribution, Metabolism, and Excretion) study was conducted to evaluate the synthesized compounds' pharmacokinetic and drug‐likeness properties. The results manifested that almost all the investigated compounds' properties were compatible with the specified optimal range, which indicates their reassuring pharmacokinetic properties.
Skeletal age during hurricane impacts fluctuating asymmetry in Cayo Santiago rhesus macaques
Authors: Romero Ashly N. , Dickinson Edwin , Turcotte Cassandra M. , Terhune Claire E. 
Published: August 2023

AbstractAs natural disasters become more frequent due to climate change, understanding the biological impact of these ecological catastrophes on wild populations becomes increasingly pertinent. Fluctuating asymmetry (FA), or random deviations from bilateral symmetry, is reflective of developmental instability and has long been positively associated with increases in environmental stress. This study investigates craniofacial FA in a population of free‐ranging rhesus macaques (Macaca mulatta) that has experienced multiple Category 3 hurricanes since the colony's inception on Cayo Santiago, including 275 individuals from ages 9 months to 31 years (F = 154; M = 121). Using geometric morphometrics to quantify FA and a linear mixed‐effect model for analysis, we found that sex, age, and decade of birth did not influence the amount of FA in the individuals included in the study, but the developmental stage at which individuals experienced these catastrophic events greatly impacted the amount of FA exhibited (p = .001). Individuals that experienced these hurricanes during fetal life exhibited greater FA than any other post‐natal developmental period. These results indicate that natural disasters can be associated with developmental disruption that results in long‐term effects if occurring during the prenatal period, possibly due to increases in maternal stress‐related hormones.
Trichloromethylative Olefin Lactonization by Photoredox Catalysis
Authors: Harada Shinji , Koyama Ryotaro , Masuda Ryuya , Arai Shigeru 
Published: August 2023

AbstractA trichloromethylative olefin lactonization reaction using an iridium photoredox catalyst was developed. The reactions proceeded at room temperature for olefins with various substituents and substitution patterns, and a variety of lactones with a tetrasubstituted carbon and trichloromethyl group were obtained regio‐ and stereoselectively. The reaction mechanism was elucidated through isotope labeling experiments. The chemical properties of the lactones containing the trichloromethyl groups were investigated, and synthetic transformations of the product were realized.