bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protection against doxorubicin-induced cardiotoxicity by ergothioneine
Authors: Cheah Irwin K. , Tang Richard M.Y. , Wang Xiaoyuan , Sachaphibulkij Karishma , Chong Suet Yen , Lim Lina H.K. , Wang Jiong-Wei , Halliwell Barry 
Published: December 2022

AbstractAnthracyclines such as doxorubicin remain the first line of treatment for haematological malignancies, and breast cancers. However, the potential risk of cardiac injury by anthracyclines, which may lead to severe myopathy or heart failure, severely limits their application, and remains a challenge to ensuring curative chemotherapy. While the complex interplay between pathological pathways of anthracycline cardiotoxicity is yet to be fully understood, oxidative damage, iron overload-mediated formation of reactive oxygen species (ROS), mitochondrial dysfunction, and inflammation are all believed to be involved.The unique dietary thione, ergothioneine, while not produced in animals and humans, can be avidly absorbed and accumulated in tissues including the heart. Amongst other cytoprotective properties ergothioneine has been shown to scavenge various ROS, decrease proinflammatory mediators, chelate metal cations such as Fe2+, preventing them from partaking in redox activities, and may protect against mitochondrial damage and dysfunction. Moreover, low plasma ergothioneine levels are also strongly correlated to risk of cardiovascular events in humans, suggestive of a cardioprotective role. Taken together this highlights the potential for ergothioneine to counteract anthracycline cardiotoxicity.Here we investigate the potential of ergothioneine supplementation to protect against cardiac dysfunction in mice models of doxorubicin-induced cardiotoxicity and found that it had significant protective effects. Moreover, ergothioneine administration in a mouse breast cancer model did not exacerbate the growth of the tumour and did not interfere with the chemotherapeutic efficacy of doxorubicin. These results suggest that ergothioneine could be a viable co-therapy to alleviate the cardiotoxic effects of anthracyclines in the treatment of cancers.
Cholesterol-deficient T cell membrane-encapsulated STING agonists for tumor-targeted immunotherapy
Authors: Li Lin , Zhang Mengxing , Liu Tiantian , Zhang Zhirong , Liu Zhenmi , Zhang Ling 
Published: December 2022

AbstractIn recent years, STING agonists have shown promising results in enhancing tumor immunotherapies. Nanoparticle-based tumor targeting delivery of STING agonists is considered as an important way to improve the therapeutic efficacy and reduce the side effects of STING agonists. However, how to escape the clearance to nanoparticles by phagocytes in the blood while maintaining the tumor targeting efficiency of nanoparticles is still a big challenge. Herein, cholesterol-deficient membrane from bioengineered T cells overexpressing PD-1 encapsulated STING agonist SR-717 (a.k.a. COMs) was used to treat melanoma. Nanoparticles coated by these membranes displayed remarkably dropped clearance by monocytes in the blood in both animal and human blood comparing with nanoparticles coated by non-modified T cell membrane, while maintaining the high tumor cell targeting efficiency of COMs. In mice melanoma model, intravenous injected COMs successfully delivered SR-717 to tumor and activated STING pathways and the PD-1 on COMs blocked the up-regulated PD-L1 in tumor cells induced by SR-717. As a result, COMs stimulated strong tumor immune responses to inhibit melanoma recurrence when it combined with photothermal therapy (PTT). In summary, this study developed a highly effective bionic system that integrated STING activation and immunotherapy, and provided a simple and effective strategy to enhance performance of cell membrane-coated delivery systems in vivo.
Legionella pneumophilainhibits type I interferon signaling to avoid cell-intrinsic host cell defense
Authors: Allen C.N.S. , Banks D. A. , Shuster M. , Vogel S. N. , O’Connor T.J. , Briken V. 
Published: December 2022

AbstractThe host type I interferon (IFN) response protects againstLegionella pneumophilainfections. Other bacterial pathogens inhibit type I IFN-mediated cell signaling; however, the interaction between this signaling pathway andL. pneumophilahas not been well described. Here, we demonstrate thatL. pneumophilainhibits the IFN-β signaling pathway but does not inhibit IFN-ψ-mediated cell signaling. The addition of IFN-β toL. pneumophila-infected macrophages limited bacterial growth independently of NOS2 and reactive nitrogen species. The type IV secretion system ofL. pneumophilais required to inhibit IFN-β-mediated cell signaling. Finally, we show that the inhibition of the IFN-β signaling pathway occurs downstream of STAT1 and STAT2 phosphorylation. In conclusion, our findings describe a novel host cell signaling pathway inhibited byL. pneumophilavia its type IV secretion system.
On the changing role of individuals in different age groups in propagating the Omicron epidemic waves in France
Authors: Goldstein Edward 
Published: December 2022

AbstractObjectivesIn late December 2022, rates of mortality in France (over 2,500 daily deaths) have reached levels not seen since April 2020, with the most pronounced increase in mortality recorded in nursing homes. Epidemics of Omicron and influenza have both contributed to those high mortality levels in late 2022. The roles of different age groups in propagating Omicron epidemics in the whole community require a better characterization, particularly given that in France, vaccination coverage for the 2nd booster for COVID-19 is limited and largely restricted to persons aged over 60y.Patients and MethodsWe examined the role of individuals in different age groups in propagating different waves of Omicron epidemics in France between March 1--Dec. 30, 2022 using previously developed methodology based on the relative risk (RR) statistic that measures the change in the group’s proportion among all cases before vs. after the peak of an epidemic wave. Higher value of the RR statistic for a given age group suggests a disproportionate depletion of susceptible individuals in that age group during the epidemic’s ascent (due to increased contact rates and/or susceptibility to infection).ResultsFor the Spring wave (March 14 - May 15), the highest RR estimate belonged to children aged 10-19y (RR=1.92 (95% CI (1.18,3.12)), followed by adults aged 40-49y (RR=1.45 (1.09,1.93)) and children aged 0-9y (RR=1.31 (0.98,1.74)). For the Summer wave (June 27 – Aug. 21), the highest RR estimate belong to children aged 0-9y (RR=1.61 (1.13,2.30)) followed by children aged 10-19y (RR=1.59 (0.77,3.26)) and adults aged 20-29y (RR=1.42 (0.91,2.23)). For the Autumn wave (Sep. 18 – Nov. 12), the highest RR estimate belonged to children aged 10-19y (RR=1.65 (0.72,3.75)), followed by adults aged 30-39y (RR=1.39 (0.83,2.33)) and 20-29y (RR=1.21 (0.66,2.23)). For the Autumn-Winter Wave (Nov. 23 – Dec. 30), the highest RR estimate belonged to persons aged 30-39y (RR=1.43 (0.79,2.57)), followed by persons aged 80-89y (RR= 1.17 (0.99,1.4)) and persons aged 40-49y (RR= 1.15 (0.73,1.82))).Discussion/ConclusionsIncreasing booster vaccination coverage for all adults, as possibly for children should help mitigate future Omicron epidemics. The estimate for the RR statistic in persons aged 80-89y for the Autumn-Winter Omicron wave suggests that additional efforts should be considered for preventing the spread of Omicron infection in elderly persons, including in Long-Term Care facilities.
A clickable photosystem I, ferredoxin, and ferredoxin NADP+reductase fusion system for light-driven NADPH regeneration
Authors: Medipally Hitesh , Mann Marvin , Kötting Carsten , van Berkel Willem J. H. , Nowaczyk Marc M. 
Published: December 2022

AbstractPhotosynthetic organisms like plants, algae, and cyanobacteria use light for the regeneration of dihydronicotinamide dinucleotide phosphate (NADPH). The process starts with the light-driven oxidation of water by photosystem II (PSII) and the released electrons are transferred via the cytochromeb6fcomplex towards photosystem I (PSI). This membrane protein complex is responsible for the light-driven reduction of the soluble electron mediator ferredoxin (Fd), which passes the electrons to ferredoxin NADP+reductase (FNR). Finally, NADPH is regenerated by FNR at the end of the electron transfer chain. In this study, we established a clickable fusion system for in vitro NADPH regeneration with PSI-Fd and PSI-Fd-FNR, respectively. For this, we fused immunity protein 7 (Im7) to the C-terminus of the PSI-PsaE subunit in the cyanobacteriumSynechocystissp. PCC 6803. Furthermore, colicin DNase E7 (E7) fusion chimeras of Fd and FNR with varying linker domains were expressed inE. coli. Isolated Im7-PSI was coupled with the E7-Fd or E7-Fd-FNR fusion proteins through high-affinity binding of the E7/Im7 protein pair. The corresponding complexes were tested for NADPH regeneration capacity in comparison to the free protein systems demonstrating the general applicability of the strategy.
P-element invasions inDrosophila erectashed light on the establishment of host control over a transposable element
Authors: Selvaraju Divya , Wierzbicki Filip , Kofler Robert 
Published: December 2022

AbstractTo prevent the spread of transposable elements (TEs) hosts have developed sophisticated defence mechanisms. In mammals and invertebrates this defence mechanism operates through piRNAs. It is unclear how piRNA-based defences are established against invading TEs. According to the trap model, a TE insertion into a piRNA cluster, i.e. a distinct genomic locus, activates the host defence. Alternatively, siRNAs, generated by cleavage of dsRNA, may be the trigger for host control. To investigate this we introduced the P-element, one of the most widely studied eukaryotic transposons, into naïve lines ofDrosophila erecta. We monitored the invasion in 3 replicates for more than 50 generations by sequencing the genomic DNA (using short and long-reads), the small RNAs and the transcriptome at regular intervals. A piRNA based host defence was rapidly established in 2 replicates but not in the third, where P-element copy numbers kept increasing for over 50 generations. We found that siRNAs emerged prior to piRNAs, supporting the view that siRNAs initiate host defence. However, neither insertions in piRNA clusters nor the formation of siRNAs were sufficient to stop the P-element. Instead the activation of the ping-pong cycle was shown to be crucial. We introduce a novel model, the crank-up model, which emphasizes activation of the ping-pong cycle as a critical event in establishing host control over a TE.
4931414P19Rik: A Chemoattractant Secreted by Neural Progenitors Modulates Microglia Activation and Neuronal Migration During Mammalian Brain Development
Authors: Mestres Ivan , Calegari Federico 
Published: December 2022

ABSTRACTCommunication between the nervous and immune system is critical for development, homeostasis and response to injury. Prior to the onset of neurogenesis, microglia populate the central nervous system serving as resident immune cells over the course of life. Here, we describe new roles of an uncharacterized transcript upregulated by neurogenic progenitors during mouse corticogenesis: 4931414P19Rik (hereafter named P19). Overexpression of P19 cell-extrinsically inhibited neuronal migration and acted as chemoattractant of microglial cells. Interestingly, effects on neuronal migration were found to result as a direct consequence of P19 secretion by neural progenitors triggering microglia activation and their accumulation within the P19 targeted area. Our findings highlight the critical role of microglia activation during brain development and identify P19 as a novel player in the neuro-immune crosstalk.
Assessing the shoreline dynamics on Kuakata, coastal area of Bangladesh: a GIS- and RS-based approach
Authors: Uddin Md. Jahir , Niloy Md. Nymur Rahman , Haque Md. Nazmul , Fayshal Md. Atik 
Published: December 2022

PurposeThis study aims to determine shoreline change statistics and net erosion and accretion, along the Kuakata Coast, a magnificent sea beach on Bangladesh’s southernmost point.Design/methodology/approachThe research follows a three stages way to achieve the target. First, this study has used the geographic information system (GIS) and remote sensing (RS) to detect the temporal observation of shoreline change from the year 1991 to 2021 through satellite data. Then, the digital shoreline analysis system (DSAS) has also been explored. What is more, a prediction has been done for 2041 on shoreline shifting scenario. The shoreline displacement measurement was primarily separated into three analytical zones. Several statistical parameters, including Net Shoreline Movement (NSM), Shoreline Change Envelope (SCE), End Point Rate (EPR) and Linear Regression Rate (LRR) were calculated in the DSAS to quantify the rates of coastline movement with regard to erosion and deposition.FindingsEPR and LRR techniques revealed that the coastline is undergoing a shift of landward (erosion) by a median rate of 3.15 m/yr and 3.17 m/yr, respectively, from 1991 to 2021, 2.85 km2 of land was lost. Naval and climatic influences are the key reasons for this variation. This study identifies the locations of a significantly eroded zone in Kuakata from 1991 to 2021. It highlights the places that require special consideration while creating a zoning plan or other structural design.Originality/valueThis research demonstrates the spatio-temporal pattern of the shoreline location of the Kuakata beach, which would be advantageous for the region’s shore management and planning due to the impacts on the fishing industry, recreation and resource extraction. Moreover, the present research will be supportive of shoreline vulnerability. Hence, this study will suggest to the local coastal managers and decision-makers for particularizing the coastal management plans in Kuakata coast zone.
Accounting and accountability in Muslim secondary schools in Tanzania: a Bourdieusian perspective
Authors: Mzenzi Siasa Issa 
Published: December 2022

PurposeThis paper investigates the relationship between accounting and accountability practices in Muslim secondary schools in Tanzania using Bourdieusian perspective. The purpose of this paper is to address this issue.Design/methodology/approachIn-depth interviews were conducted with school owners, teachers, accountants, an imam and leaders of Muslim organizations. Corroborative evidence was gathered through review of documentary sources. The data were analyzed using a mapping approach.FindingsThe findings show that powerful actors in the schools studied proactively selected accounting practices that supported their particular doxa of survival, access or legitimacy. Also, Fiisabilillah is identified as an existential doxa, and this was found to be more influential than individual accountability doxa and responsible for adherence to work among weak agents despite an inappropriate environment. As a result, accounting practices become “rhetoric” and play a minimal role in discharging both “sacred” and “secular” accountability to both human beings and God.Practical implicationsThe findings suggest that accounting practices must be understood in the context of the socioeconomic and political settings in which the organization operates.Originality/valueMost studies of accounting and accountability have focused on developed countries. This is one of the few studies to explore the phenomenon in the context of Muslim schools in a developing country.
Impact of multiple commitments on the performance of open innovation projects: the mediating role of trusted and vigilant knowledge interaction
Authors: Qin Yanjun , Wang Jun 
Published: December 2022

Purpose
Based on commitment system theory and commitment-trust theory, this study aims to reveal the effects of participating teams’ multiple commitments (i.e. synergistic commitments and conflicting commitments) on the performance of open innovation projects through the mediating role of trusted knowledge interaction and vigilant knowledge interaction.

Design/methodology/approach
Primary survey data collected from 242 respondents of 47 open innovation projects in the manufacturing industry was used to test eight hypotheses. Correlations between multiple commitments, knowledge interaction and the performance of open innovation projects were investigated.

Findings
The findings reveal that synergistic commitments improve the performance of open innovation projects through enhancing trusted knowledge interaction. Synergistic commitments reduce the level of vigilant knowledge interaction, and the performance of open innovation projects follows an inverted U-shaped relationship with vigilant knowledge interaction. Conflicting commitments negatively moderate the effect of synergistic commitments on trusted knowledge interaction and vigilant knowledge interaction.

Originality/value
The authors extend commitment system theory and commitment-trust theory to open innovation project field. The findings bridge the gaps in isolated and static focus in previous commitment literatures and innovation management literatures, and provide practical guidance for how to better manage the dynamic combination of multiple commitments and knowledge interaction among participating teams in open innovation projects.
Help over harm: practical and ethical considerations for the evaluation and deployment of therapeutic games
Authors: Barnes Steven , Chandler Tara , Granda-Salazar Mishell 
Published: December 2022

Purpose
The aim of this paper is to collate and discuss a number of key issues regarding the development, deployment and monitoring of games designed for therapeutic purposes.

Design/methodology/approach
The authors collate a number of core areas for consideration and offer suggestions regarding the challenges facing the field of therapeutic gaming.

Findings
In this paper, four major areas of interest are presented: ensuring and communicating therapeutic game effectiveness; data-security and management; effective game design; and barriers to therapeutic game uptake and engagement. Present implications of these issues are discussed and suggestions are provided for further research and to help move the field toward establishing consensus regarding standards of practice.

Originality/value
This paper represents, to best of the authors’ knowledge, the first of its kind in the field of therapeutic games to collate and address the core issues facing the development, deployment and growth of this potentially valuable medium.
Fashioning female feet at the turn of the twentieth century: US Cinderellas, Chinese alterity or global beauty?
Authors: He Fang 
Published: December 2022

AbstractScholars have only paid limited attention to petite feet as a US fashion and as a cross‐cultural beauty ideal. Framed as a visual metaphor of Chinese alterity, traditionalism and patriarchal oppression, footbinding served as a crucial terrain in which the USA asserted its supremacy through a racialised discourse of difference at the turn of the twentieth century. Through a comparative lens, this article spotlights powerful details about shared ideologies of women's bodies in the USA and China. By tracing how women's feet were discussed in newspaper and magazine coverage of US small foot fashion and foot contests, and locating these narratives in a global context, it uncovers the ways in which the discourse of modernity, ideology of white superiority and imperialism naturalised Western women's foot beauty norm as an aesthetic ideal, which obscured the convergences of feminine beauty standards in different parts of the world. Ironically, this racialised global hierarchy of beauty under the guise of modernity tapped into a traditional form of femininity and upset efforts to reflect on the limits of white women's agency both in a traditional patriarchal culture and in a modernising US society, which ultimately constrained possibilities of local and global transformations.
The interactive effect of job skill level and citizenship status on job depression, work engagement and turnover intentions: A moderated mediation model in the context of macro‐level turbulence (of ‘Brexit’)
Authors: Martinescu Elena , Edwards Martin R. , Leite Ana.C. , Randsley de Moura Georgina , Marques André G. , Abrams Dominic 
Published: December 2022

AbstractThis study examines the role that citizenship plays in moderating the relationship between job‐skill level, work‐related depression, engagement, and turnover‐intentions for UK based employees across 6 months in the year following the Brexit referendum. In two waves of data collection, citizenship moderated the relationship between job‐skill level and depressive states; among EU citizens, those in low skilled jobs experienced greater depressive states than employees in high skilled jobs, this difference was not found among UK citizens. Furthermore, depressive states were subsequently related with low work engagement and high turnover intentions and citizenship moderated the indirect‐effect of job skill on engagement and turnover intentions via depressive states. This study shows that during the turbulent times following the Brexit referendum, EU citizens in the UK with low‐skilled jobs were most affected by depressive states, were subsequently less engaged and showed higher levels of intent to quit.
Metabolism studies of 4′Cl‐CUMYL‐PINACA, 4′F‐CUMYL‐5F‐PINACA and 4′F‐CUMYL‐5F‐PICA using human hepatocytes and LC‐QTOF‐MS analysis
Authors: Stalberga Darta , Ingvarsson Sarah , Bessa Ghidaa , Maas Lisa , Vikingsson Svante , Persson Mattias , Norman Caitlyn , Gréen Henrik 
Published: December 2022

Abstract4′Cl‐cumyl‐PINACA (SGT‐157), 4′F‐cumyl‐5F‐PINACA (4F‐cumyl‐5F‐PINACA, SGT‐65) and 4′F‐cumyl‐5F‐PICA (4F‐cumyl‐5F‐PICA, SGT‐64) are a series of new halogenated cumyl synthetic cannabinoid receptor agonists (SCRAs). Due to rapid metabolism, monitoring and screening for SCRAs in biological matrices requires identification of their metabolites. It is an essential tool for estimating their spread and fluctuations in the global illicit market. The purpose of this study was to identify human biotransformations of 4′Cl‐cumyl‐PINACA, 4′F‐cumyl‐5F‐PINACA and 4′F‐cumyl‐5F‐PICA in vitro and characterize for the first time the metabolic pathways of halogenated cumyl SCRAs. 4′Cl‐cumyl‐PINACA, 4′F‐cumyl‐5F‐PINACA and 4′F‐cumyl‐5F‐PICA were incubated with human hepatocytes in duplicates for 0, 1, 3 and 5 h. The supernatants were analysed in data‐dependent acquisition on a UHPLC‐QToF‐MS, and the potential metabolites were tentatively identified. A total of 11 metabolites were detected for 4′Cl‐cumyl‐PINACA, 21 for 4′F‐cumyl‐5F‐PINACA and 10 for 4′F‐cumyl‐5F‐PICA. The main biotransformations were oxidative defluorination, followed by hydroxylation with dehydrogenation, N‐dealkylation, dihydrodiol formation and glucuronidation. Hydroxylations were most common at the tail moieties with higher abundancy for indole than indazole compounds. N‐dealkylations were more common for fluorinated tail chain compounds than the non‐fluorinated 4′Cl‐cumyl‐PINACA. In conclusion, many metabolites retained halogen groups at the cumyl moieties which, in various combinations, may be suitable as analytical biomarkers.