bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of CannEpil® on simulated driving performance and co-monitoring of ocular activity: A randomised controlled trial
Authors: Manning Brooke , Hayley Amie C , Catchlove Sarah , Shiferaw Brook , Stough Con , Downey Luke A 
Published: May 2023

Background: Medicinal cannabis products containing Δ9-tetrahydrocannabinol (THC) are increasingly accessible. Yet, policy guidelines regarding fitness to drive are lacking, and cannabinoid-specific indexations of impairment are underdeveloped. Aims: To determine the impact of a standardised 1 mL sublingual dose of CannEpil®, a medicinal cannabis oil containing 100 mg cannabidiol (CBD) and 5 mg THC on simulated driving performance, relative to placebo and whether variations in vehicle control can be indexed by ocular activity. Methods: A double-blind, within-subjects, randomised, placebo-controlled, crossover trial assessed 31 healthy fully licensed drivers (15 male, 16 female) aged between 21 and 58 years ( M = 38.0, SD = 10.78). Standard deviation of lateral position (SDLP), standard deviation of speed (SDS) and steering variability were assessed over time and as a function of treatment during a 40 min simulated drive, with oculomotor parameters assessed simultaneously. Oral fluid and plasma were collected at 30 min and 2.5 h. Results: CannEpil did not significantly alter SDLP across the full drive, although increased SDLP was observed between 20 and 30 min ( p < 0.05). CannEpil increased SDS across the full drive ( p < 0.05), with variance greatest at 20–30 min ( p < 0.001). CannEpil increased fixation duration ( p < 0.05), blink rate (trend p = 0.051) and decreased blink duration ( p < 0.001) during driving. No significant correlations were observed between biological matrices and performance outcomes. Conclusions: CannEpil impairs select aspects of vehicle control (speed and weaving) over time. Alterations to ocular behaviour suggest that eye tracking may assist in determining cannabis-related driver impairment or intoxication. Australian and New Zealand Clinician Trials Registry, https://anzctr.org.au(ACTRN12619000932167) .
Effect of Repetitive Corticosteroid Injection on Tennis Elbow Surgery
Authors: Ha Cheungsoo , Cho Weonmin , Hong In-Tae , Park Junhyoung , Ahn Wooyeol , Han Soo-Hong 
Published: May 2023

Background: Lateral epicondylitis is a chronic tendinopathy of humeral origin of the common extensor tendon. Most patients show improvement after nonoperative treatment. However, 4% to 11% of patients require surgical treatment. Although corticosteroid injection is one of the most commonly applied nonoperative treatment methods, to the authors’ knowledge, no study has reported the effect of the number of preoperative corticosteroid injections on the final postoperative outcome. Thus, the objective of this study was to determine the effect of the number of preoperative corticosteroid injections on postoperative clinical outcomes. Hypothesis: The number of corticosteroid injections before surgical treatment does not affect postoperative clinical outcomes. Study Design: Case series; Level of evidence, 4. Methods: As a retrospective review, from January 2007 to December 2019, a total of 99 patients who had undergone surgical treatment of lateral epicondylitis with a modified Nirschl technique were enrolled. The number of preoperative corticosteroid injections was investigated by medical record review. Outcome measurements included visual analog pain scale; Disabilities of the Arm, Shoulder and Hand (DASH) score; Mayo Elbow Performance Score; and the Nirschl and Pettrone grade. Grip power and wrist extension power were measured using a digital dynamometer. Results: A total of 99 patients were included in this study. The mean total number of injections of patients was 4.37 ± 2.46 times (range, 1-15 times). Total duration of nonoperative treatment before surgery was 25.4 ± 20.5 months (range, 4-124.8 months). The mean postoperative follow-up period was 42.8 ± 28.0 months (range, 12-110 months). For all injection numbers, clinical scores showed significant improvement in visual analog pain scale, DASH score, Mayo elbow score, grip power, and wrist extension power after surgery. Regression analysis showed that the degree of improvement according to the injection number was not statistically significant. The Nirschl and Pettrone grade was excellent in 82 (82.8%) patients, good in 14 (14.1%) patients, fair in 2 (2%) patient, and failure in 1 (1%) patient. Conclusion: The number of preoperative corticosteroid injections does not appear to affect postoperative clinical outcomes of patients with lateral epicondylitis who undergo surgery with a modified Nirschl technique.
Irreversible Electroporation Improves Tendon Healing in a Rat Model of Collagenase-Induced Achilles Tendinopathy
Authors: Wang Xin , Xu Kui , Zhang Eryang , Bai Qian , Ma Baoan , Zhao ChenGuang , Zhang Kailiang , Liu Tao , Ma Zhouyong , Zeng Hui , Zhou Yong , Li Zhao 
Published: May 2023

Background: Treatment of painful chronic tendinopathy is challenging, and there is an urgent need to develop new regenerative methods. Irreversible electroporation (IRE) can lead to localized cell ablation by electrical pulses and induce new cell and tissue growth. Previously, the authors’ group reported that electroporation-ablated tendons fully regenerated. Purpose: To assess the efficiency of IRE in improving tendon healing using a collagenase-induced Achilles tendinopathy rat model. Study Design: Controlled laboratory study. Methods: After screening for the IRE ablation parameters, a collagenase-induced Achilles tendinopathy rat model was used to assess the efficacy of IRE in improving tendon healing via biomechanical, behavioral, histological, and immunofluorescence assessments. Results: The experiments showed that the parameter of 875 V/cm 180 pulses could ablate most tenocytes, and apoptosis was the main type of death in vitro. In vivo, IRE promoted the healing process of chronic tendinopathy in the Achilles tendon of rats, based on biomechanical, behavioral, and histological assessments. Finally, immunofluorescence results revealed that IRE improved blood supply in the early stages of tendon repair and could potentially reduce neuropathic pain. Conclusion: IRE enhanced tendon tissue healing in a rat model of collagenase-induced Achilles tendinopathy. Clinical Relevance: IRE may as a potential alternative treatment for tendinopathy in clinical usage.
“Smile for the camera”: Online warehouse tours as a form of dark tourism within the era of late capitalism
Authors: Lynes Adam , Wragg Esme 
Published: May 2023

Over the past 50 years dark tourism has also seen exponential growth in terms of both physical and digital contexts. Dark tourism is primarily a concentration around documented accounts of physical violence, and theorisations centred on dark tourism studies have generally fallen within either behavioural or interpretivist perspectives. Such perspectives are indicative of the continually evolving nature of dark tourism and its receptiveness to new definitions, conceptual frameworks, and theorisations. Taking this into consideration, this concept paper seeks to develop and broaden the notion of “dark tourism” within the era of late capitalism by presenting a content analysis of Amazon’s virtual warehouse tour. In drawing upon critical notions of violence and the emerging deviant leisure framework, this paper will aim to instigate fresh academic enquiry into the nature of dark tourism, expand its theoretical underpinnings, and subsequently provide a means in which to examine how banal forms of tourism play an integral part in the proliferation of some of the most serious harms that populate the contemporary neoliberal landscape. Within this fresh interpretation of dark tourism, this paper also examines the relationship between the Internet, technology and late-stage capitalism, and the implications that this has in studying how corporations use such forms of media in tourism production in order to downplay and obfuscate the realities behind their activities.
Decreased Complication Rate Using Partially Threaded Compared With Fully Threaded Compression Screws in 4 Corner Arthrodesis: A Retrospective Study
Authors: Hanna Tammam , Smith Nathan , Akalonu Chibuzo , Simmons Jack , Nehete Priyanka V. , Dodson Mark 
Published: May 2023

Background: Scapho-lunate advanced collapse (SLAC) and scaphoid nonunion advanced collapse (SNAC) of the wrist are the most common types of wrist arthritis. We compared the union rate and complication profile of patients with SLAC and SNAC wrist undergoing 4 corner arthrodesis with partially threaded or fully threaded headless compression screws. Methods: A single-center retrospective review was conducted to identify all patients treated for SLAC and SNAC with 4 corner fusion using headless compression screws from 2016 to 2021. A total of 33 patients undergoing surgery on 35 wrists were identified and included in the study. Demographics, comorbidities, complication profile, and radiographs were collected and compared between groups. Results: One hundred percent (16/16) of partially threaded and 84.2% (16/19) of fully threaded screws demonstrated union by minimum 10-week follow-up. The total complication rate (avascular necrosis of lunate, screw loosening, etc.) was 31.4%; 52.6% of wrists implanted with fully threaded screws experienced complications compared with a 6.3% complication rate with partially threaded screws. The difference was statistically significant between the 2 groups ( P = .004). Conclusions: Four corner arthrodesis using antegrade compression screws is an effective, reproducible method to achieve fusion in the wrist. The use of fully threaded screws was associated with more complications than with partially threaded screws, although union rate was not significantly different. Future studies with larger sample sizes would be useful to fully elucidate differences between these 2 constructs.
Medial Ulnar Collateral Ligament Repair With Augmentation: A Systematic Review and Meta-analysis of Preclinical Studies
Authors: Boksh Khalis , Mishra Pranav , Akram Nimra , Abdolrazaghi Sina , Singh Harvinder 
Published: May 2023

Background: Reconstruction is the gold standard treatment for medial ulnar collateral ligament (MUCL) injuries. However, recent studies show a successful and renewed interest in direct suture repair, particularly in young athletes. Repair augmentation with a suture tape may provide greater stability, enabling healing of the MUCL while protecting the repair at higher valgus loads. Purpose: To perform a systematic review and meta-analysis on whether MUCL repair with augmentation provides a similar biomechanical profile to the traditional MUCL reconstruction. Study Design: Systematic review. Methods: The Cochrane Controlled Register of Trials, PubMed, Medline, and Embase were used to perform a systematic review and meta-analysis using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria with the following search terms: (“ulnar collateral ligament” OR “medial ulnar collateral ligament”) AND (“internal brace” OR “augmentation” OR “suture tape”). Data pertaining to certain biomechanical properties (gap formation, failure to torque [ultimate load to failure], stiffness, degree of valgus opening, and modes of failure) were extracted. The pooled outcome data were analyzed by random- and fixed-effects models. A total of 203 abstracts were identified through the aforementioned databases. Results: After abstract and full-text screening, 6 biomechanical studies were included. All were on cadaveric elbows, with 53 repairs with augmentation and 53 reconstructions compared. There were no differences between the 2 in regard to ultimate load to failure (standard mean difference [SMD], –0.34 N·m; 95% CI, –1.36 to 0.68; P = .51) and rotational stiffness (SMD, 0.26; 95% CI, –1.14 to 1.66; P = .72). Despite a trend in resistance to gapping with augmented repair, this was not significant (SMD, –0.53; 95% CI, –1.08 to 0.01; P = .06). Augmented repairs were more likely to fail by pullout or at the suture-tendon/anchor-suture interface (odds ratio [OR], 12.19; 95% CI, 4.17 to 35.62; P < .00001), while failure by fracture was more common with reconstruction (OR, 5.75; 95% CI, 2.07 to 15.99; P = .0008). Conclusion: MUCL augmented repair establishes the required time-zero structural properties without the need for a tendon graft. However, future clinical studies are necessary to determine its true effectiveness as well as its success at higher levels of professional sport.
Comparison of Psychological Readiness to Return to Sport After Primary Versus Revision Anterior Cruciate Ligament Reconstruction
Authors: Duncan Brian R. , Reid Matthew , Kleihege Jacquelyn , Higbie Steven , Gardner Emily P. , Lowe Walter , Bailey Lane 
Published: May 2023

Background: Rates of return to preinjury level of play after anterior cruciate ligament (ACL) reconstruction (ACLR) remain unsatisfactory, particularly for patients who undergo revision surgery. Psychological readiness is associated with successful return to sport (RTS) and self-perceived preinjury sport performance. Purpose: To compare psychological readiness at RTS between patients who underwent revision ACL autograft reconstruction and matched controls who underwent primary ACL autograft reconstruction. Study Design: Cohort study; Level of evidence, 3. Methods: Data were gathered using a single orthopaedic surgeon database of patients who underwent ACLR between 2015 and 2018. Patients who underwent revision ACLR and met the study criteria (N = 92) were matched by age, sex, graft type, and rehabilitation protocol to a control group of patients who underwent primary ACLR (n = 92). Functional assessment at release to play was examined using passive knee range of motion, single-leg squat, and single-leg hop testing. Self-reported outcomes included the International Knee Documentation Committee subjective function survey and the ACL–Return to Sport after Injury (ACL-RSI) psychological readiness scale. Time to release to play was recorded as the number of months needed to reach a ≥90% limb symmetry index from the date of the index ACLR. Data were assessed for normality using the Shapiro-Wilk test, and univariate general linear models were utilized with an alpha level of .05. Results: The overall mean patient age was 29.9 ± 10 years, and 40% of patients were women. No significant differences between groups were noted in any of the baseline patient characteristics or surgical findings. At RTS, the mean ACL-RSI score was significantly lower in the revision surgery group (77.4 ± 19.4 vs 85.3 ± 17.4; P = .011). In addition, the revision surgery group returned to play significantly later than the primary surgery group (9.4 ± 2 vs 8.1 ± 1.3 months, respectively; P < .001). Conclusion: When compared with primary ACL autograft reconstruction, revision reconstruction patients exhibited lower psychological readiness scores and a longer time to meet the objective criteria for RTS. Registration: NCT03704376 ( ClinicalTrials.gov identifier).
E-Learning Medical Education in Gaza During COVID-19: Students’ Experiences and Policy Recommendations
Authors: Ismail Alaa , Ismail Anas , Alazar Ameera , Saman Mosab , Abu-Elqomboz Ayham , Sharaf Fawzi Khalil 
Published: May 2023

Objectives We explored medical students’ perspectives on and experiences of e-learning in Gaza and proposed relevant policy recommendations. Methods We administered an online questionnaire to medical students in Gaza exploring (1) demographics, computer skills, and time spent on e-learning; (2) students’ perception and challenges of e-learning; and (3) students’ preferences of continuing medical e-learning in the future. Analysis was done using SPSS version 23. Results Out of 1830 students invited, 470 responded, and 227 of them were basic-level students. More female students responded (58.3%, n = 256). Most participants ( n = 413, 87.9%) reported moderate to high computer skills allowing them to access e-learning. Before coronavirus disease-19 (COVID-19), over two-thirds ( n = 321, 68.3%) spent 0-3 hours on e-learning. After COVID-19, the majority shifted, and 306 students (65.1%) reported spending at least 7 hours on various e-learning sources. The challenges for clinical-level students were mainly related to lack of practical training in the hospital ( n = 196, 80%), followed by lack of interactions with real patients ( n = 167, 68.7%). As for basic-level students, a majority ( n = 120, 52.8%) reported lack of practical skills (eg, lab skills) as a challenge followed by unreliable internet access ( n = 119, 52.4%). Pre-recoded lectures, readily available educational videos were used more than live lectures. Less than a third of all students ( n = 147, 31.3%) wanted e-learning in the next term. Conclusions Medical students in Gaza don’t have a favourable experience with online medical education. There need to be actions to help overcome the challenges faced by students. This requires orchestrated actions by the government, universities, and local and international organizations.
Aneurysm treatment within 6 h versus 6–24 h after rupture in patients with subarachnoid hemorrhage
Authors: Vergouwen Mervyn DI , Germans Menno R , Post René , Tjerkstra Maud A , Coert Bert A , Rinkel Gabriel JE , Peter Vandertop William , Verbaan Dagmar 
Published: May 2023

Background: The risk of rebleeding after aneurysmal subarachnoid hemorrhage (aSAH) is the highest during the initial hours after rupture. Emergency aneurysm treatment may decrease this risk, but is a logistic challenge and economic burden. We aimed to investigate whether aneurysm treatment <6 h after rupture is associated with a decreased risk of poor functional outcome compared to aneurysm treatment 6–24 h after rupture. Methods: We used data of patients included in the ULTRA trial (NCT02684812). All patients in ULTRA were admitted within 24 h after aneurysm rupture. For the current study, we excluded patients in whom the aneurysm was not treated <24 h after rupture. We calculated crude and adjusted risk ratios (aRR) with 95% confidence intervals using Poisson regression analyses for poor functional outcome (death or dependency, assessed by the modified Rankin Scale) after aneurysm treatment <6 h versus 6–24 h after rupture. Adjustments were made for age, sex, clinical condition on admission (WFNS scale), amount of extravasated blood (Fisher score), aneurysm location, tranexamic acid treatment, and aneurysm treatment modality. Results: We included 497 patients. Poor outcome occurred in 63/110 (57%) patients treated within 6 h compared to 145/387 (37%) patients treated 6–24 h after rupture (crude RR: 1.53, 95% CI: 1.24–1.88; adjusted RR: 1.36, 95% CI: 1.11–1.66). Conclusion: Aneurysm treatment <6 h is not associated with better functional outcome than aneurysm treatment 6–24 h after rupture. Our results do not support a strategy aiming to treat every patient with a ruptured aneurysm <6 h after rupture.
First occurrence of the M2a2b2c polytype of argentopolybasite, [Ag6Sb2S7][Ag10S4]: Structural adjustments in the Cu-free member of the pearceite–polybasite group
Authors: Bindi Luca , Keutsch Frank N. , Topa Dan , Kolitsch Uwe , Morana Marta , Tait Kimberly T. 
Published: May 2023

AbstractThe chemistry and the crystal structure of the recently described mineral argentopolybasite are critically discussed based on the study of two new occurrences of the mineral: Gowganda, Timiskaming District, Ontario, Canada and IXL Mine, Silver Mountain mining district, Alpine County, California.The crystal structure of argentopolybasite can be described as the sequence, along the c axis, of two alternating layers: a [Ag6Sb2S7]2–A layer and a [Ag10S4]2+B layer. In the B layer there are linearly-coordinated metal positions (B sites), which are usually occupied by copper in all members of the pearceite–polybasite group, resulting in a B-layer composition [Ag9CuS4]2+. In argentopolybasite, however, Ag fills all the metal sites in both A and B layers. By means of a multi-regression analysis on 67 samples of the pearceite–polybasite group, which were studied by electron microprobe and single-crystal X-ray diffraction, the effect of Ag, Sb and Se on the B sites of the B layer was modelled. Although the nomenclature rules for these minerals are based on chemical data only, we think this approach is useful to evaluate the goodness of the refinement of the structure (Ag/Cu disorder) and thus fundamental to discriminate different members of the pearceite–polybasite group.
Crystallisation of Ca-bearing nepheline in basanites from Kajishiyama, Tsuyama Basin, Southwest Japan
Authors: Yoneoka Keiya , Hamada Maki , Arai Shoji 
Published: May 2023

AbstractCa-bearing nepheline found in the Kajishiyama basanite, Tsuyama Basin, southwest Japan, was investigated to clarify its genesis in silica-undersaturated magmas. The basanite contains olivine and augite as phenocrysts and microphenocrysts, with Ca-bearing nepheline, olivine, augite, ulvöspinel, plagioclase, alkali feldspar, apatite and zeolites in the groundmass. Zeolites are more abundant in coarser-grained samples. The whole-rock composition of the basanite is characterised by low SiO2 and P2O5 contents and high total Fe, MgO, Na2O, K2O, Ba and Sr contents.The Ca-bearing nepheline, ~20 μm in size, occurs in the mesostasis of the Kajishiyama basanite and contains up to 2.31 wt.% CaO and 16.75 wt.% Na2O, in contrast to nepheline from the Hamada nephelinite, southwest Japan. The approximate compositional formula of the Kajishiyama nepheline with the highest Ca content is (Ca0.467Ba0.013Na5.286K0.919□Total1.385)Σ8.070(Si0.912Al6.980Cr3+0.003Fe3+0.067 Mg0.017)Σ7.979Si8.000O32; i.e. Ne65.50Ks11.39Qxs11.22CaNe11.89.Basanites are defined as being nepheline-normative, however they are high in normative plagioclase, the amount of which increases with fractionation of the magma. Nepheline crystallised after plagioclase, at the last stage of magmatic solidification is enriched in Ca. Such Ca-rich nepheline only forms from a magma which is high in normative plagioclase, as is the case in the Kajishiyama basanite. In contrast, Ca-poor nepheline is precipitated from nephelinitic magmas that crystallise melilite instead of plagioclase, even when Ca contents are high.