bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Tingkat Kepatuhan Konsumsi Obat pada Pasien Hipertensi Rawat Jalan di Rumah Sakit Dewi Sri Karawang Menggunakan Metode MMAS-8
Authors: Mura Tsani Arsy , Hilmi Indah Laily , Salman Salman 
Published: March 2023

Hipertensi merupakan salah satu problematika di bidang kesehatan di seluruh dunia dan menjadi faktor risiko utama penyakit kardiovaskular. Tingkat kepatuhan minum obat pada penderita hipertensi di Jawa Barat sebanyak 55,12% rutin minum obat. Tujuan penelitian ini adalah untuk mengevaluasi tingkat kepatuhan pasien hipertensi dalam mengkonsumsi obat antihipertensi di rumah sakit Dewi Sri Karawang. Penelitian ini menggunakan metode deskriptif dengan teknik sampling purposive sampling dengan pendekatan prospektif. Penelitian ini dilakukan di Rumah Sakit Dewi Sri Karawang dalam jangka waktu Februari – April 2022. Pada penelitian ini diperoleh hasil 137 sampel pasien hipertensi dengan tiga kategori kepatuhan konsumsi obat anti hipertensi. Hasil penelitian ditemukan sebanyak 90 pasien. Karakteristik pasien yang terlibat dalam penelitian ini cenderung wanita sebanyak 54%, usia 41-50 tahun sebanyak 46,0%, dan pekerjaannya sebagai karyawan sebanyak 35%. Tingkat kepatuhan penggunaan obatnya beragam, di mana 90 pasien (65,7%) berada pada tingkat kepatuhan sedang, 40 pasien (29,2%) pada tingkat kepatuhan rendah, dan 7 pasien (5,1%) pada tingkat kepatuhan tinggi. Berdasarkan hasil penelitian dapat disimpulkan bahwa penggunaan obat antihipertensi pada pasien rawat jalan di Rumah Sakit Dewi Sri Karawang berada di kategori kepatuhan sedang. Kata Kunci: Konsumsi Obat, Hipertensi, MMAS-8, Tingkat Kepatuhan, Kardiovaskular Hypertension is a health problem worldwide and is a major risk factor for cardiovascular disease. The prevalence of hypertension continues to increase, it is estimated that people with hypertension in 2025 will reach 29% of the number of adults worldwide. In West Java, hypertension sufferers reached 39.60%, which is the province with the second largest percentage of hypertension cases, with a compliance rate of 55.12% of patients taking the medication regularly. While in Karawang itself, based on data obtained from the West Java Health Office, the number of people with hypertension for ages over 15 years in 2019 reached 606,946 people. The purpose of this study was to evaluate the compliance level of hypertensive patients in consuming antihypertensive drugs at Dewi Sri Hospital, Karawang. This study uses a descriptive-analytic method with a prospective purposive sampling technique. This research was conducted at Dewi Sri Karawang Hospital in the period from February to April 2022. In this study, the results of 137 samples of hypertensive patients were found in three categories of adherence to antihypertensive drug consumption. A total of 90 patients (65.7%) had moderate adherence, 40 (29.2%) had low adherence, and 7 patients (5.1%) had high adherence. Based on the results of the study, it can be concluded that patients at Dewi Sri Karawang Hospital are in the category of moderate compliance.
Measurement and simulation of the propagation of impulsive acoustic emission sources in cylinders, with potential application to pipeline monitoring
Authors: Abolle-Okoyeagu Chika Judith , Torralba Javier Palacio , Chen Yuhang , Droubi Ghazi , Reuben Robert 
Published: March 2023

Abstract
Acoustic Emission (AE) monitoring of processes, machines and structures consists of using one or more surface-mounted sensor to listen for sources, which could come from structural degradation, process conditions or machine operation. Since real AE sources have a temporal structure, often over the millisecond range or longer, it is of general interest to examine what can be recovered of this temporal structure using an array of sensors of known positions relative to each other. Experiments and simulations were carried out with impulsive sources (pencil-lead breaks) and the propagating AE resulting from these sources was recorded over a period of around 2 seconds for both experiments and simulations. Two test objects were used; a solid steel cylinder to provide a relatively simple and well-studied platform to examine a number of essential principles, and a 2m length of pipe to provide some conclusions relevant to impact monitoring of pipelines. Comparison of the simulated and experimental results indicates that the frequency content of the resulting wave is not very sensitive to unloading rate at the source, although the amplitude of the simulated signal is. Comparison of the first few tens of microseconds of the simulated and experimental waveforms suggests that the first arrival is consistent with a wave speed of around 5000ms− 1. In addition, both simulations and experiments indicate that, in the sizes of the objects examined, reflections at interfaces quickly introduce interference, so the nature of the impulsive part of the source can only reasonably be preserved in the fastest-moving components of the propagating wave and before arrival of any reflections from interfaces.
The efficacy of sodium bicarbonated Ringer’s solution versus lactated Ringer's solution for goal-directed fluid therapy in elderly patients undergoing gastrointestinal surgery: a prospective randomized controlled trial
Authors: Liu Jia , Gao Yang , He Ziqing , Zhang Hao , Wu Hao , Ning Meng , Chen Lijian 
Published: March 2023

Abstract
Background

Sodium bicarbonated Ringer’s solution (BRS) has been gradually applied to clinic in recent years, while few clinical studies focused on the efficacy of BRS among elderly patients undergoing major surgery until now. This randomized controlled trial investigated the lactate metabolism and clinical outcomes of sodium bicarbonate Ringer's solution vs. sodium lactated Ringer’s solution (LRS) in elderly patients undergoing gastrointestinal surgery.

Methods

Sixty-two elderly patients undergoing gastrointestinal surgery were enrolled in this prospective, randomized controlled study. The enrolled participants were assigned into the sodium bicarbonated Ringer’s solution group (BRS group) or lactated Ringer's solution group (LRS group) randomly, which received goal-directed fluid therapy with sodium bicarbonated Ringer’s solution or sodium lactated Ringer’s solution, respectively. The primary outcome was the lactate level at the end of the surgery. Secondary outcomes included pH, bicarbonate, BE, hemodynamics, plasma biochemistry, recovery of gastrointestinal function and postoperative complications within 30 days after surgery.

Results

Sixty patients completed the trial and were analyzed finally. At the end of surgery, the level of lactate was significantly lower in BRS group than that in the LRS group (1.00 vs. 1.89, p < 0.001), and the probability of hyperlactacemia was lower (3.3% vs. 40.0%, p = 0.002). PH, bicarbonate, BE, hemodynamics, plasma biochemical alterations and postoperative gastrointestinal function recovery were not significant different between the two groups (p > 0.05). However, compared to the LRS group, the BRS group had a lower risk of wound bleeding (10.0% vs. 36.7%, p = 0.033) and newly impaired liver function (16.7% vs. 50.0%, p = 0.006), lower red blood cells infusion (0 vs. 0, p = 0.021), lower albumin infusion (10 vs. 35, p = 0.040), and shorter length of postoperative hospital stay (9 vs. 11.5, p = 0.012).

Conclusions

Sodium bicarbonated Ringer’s solution is more effective for elderly patients undergoing gastrointestinal surgery compared with sodium lactated Ringer’s solution through reducing the lactate levels, reducing the risk of wound bleeding and impaired liver function, red blood cells and albumin infusion, and decreasing the length of hospital stay.
Trial registration: This randomized trial was approved by the Clinical Medical Research Ethics Committee of the First Affiliated Hospital of Anhui Medical University, China (PJ2020-15-21) and registered at the Chinese Clinical Trial Center (http://www.chictr.org.cn/index.aspx, identifier: ChiCTR2000039406,date: 26/10/2020).
Prediction of Co2 Brazilian Emissions with Scenario Analysis Based on Energy and Environmental Indicators
Authors: Brito Marcos Lapa , Pires Carlos Augusto de Moraes , Santos Luis Carlos Lobato , Simonelli George 
Published: March 2023

Abstract
Brazil is a developing country that emits high amounts of CO2 per year. Therefore, controlling these emissions is essential to achieving sustainable development. In this paper, we modeled an Artificial Neural Network capable of quantitatively relating CO2 emissions, energy matrix, and burning in Brazilian biomes, such as the Amazon Forest. The literature still does not have studies that quanti- tatively demonstrate the impact that changes in the Brazilian energy matrix have on CO2 emissions in the country. In addition, there are also no studies that use fires in Brazilian biomes as input in predictive models for emissions. Our results showed that Brazilian CO2 emissions will increase in the coming years. However, partially replacing fossil energy resources with renewables associated with reducing fires in Brazilian biomes could significantly reduce these emissions. In our first scenario, with a partial replacement of 30% of fossil resources by renewable resources and a 70% reduction in the burning of Brazilian biomes, CO2 emissions decreased by 13.58% for the year 2030. In the second scenario analyzed, we replaced fossil fuels by 90% with renewable ones, while the burning in Brazilian biomes was reduced by 90%. We observed a 28.45% reduction in Brazilian CO2 emissions in this situation. Thus, the model developed here can help Brazil to predict and control its CO2 emissions from changes in its energy and environmental indicators to find a balance between development and sustainability. Other developing countries can also use our model. For this, the indicators must be adapted to the reality of the country studied.
Efficacy and Safety of Pentoxifylline on Patients with Non-Alcoholic Steatohepatitis; Randomized Controlled Trial
Authors: Abomandour Ahmed , Bakr Adel G. , ElGhandour Ahmed Mohamed , Elewa Hosny Ahmed , Rhman Maha Abdel , Zalat Zeinab Al Kasaby 
Published: March 2023

Abstract
Background: Actually, no specific treatment has been endorsed by FDA for non-alcoholic steatohepatitis (NASH). The present research aimed to evaluate the efficacy of PTX on NASH patients for 6 months compared to NASH patients who received regular treatment.
Methods: We assigned a 6-month, open-labeled, randomized study to 50 NASH participants who were allocated into 2 groups; firstly, the control group, patients administered regular therapy. Secondly, in the treated group, patients received regular treatment plus pentoxifylline (PTX) at 400 mg thrice daily. To achieve this goal, liver aminotransferases tests, hematological biomarkers, lipid profile, fatty liver index (FLI), fibrosis-4 (FIB-4) index, aspartate aminotransferase to platelet ratio index (APRI) and NAFLD fibrosis score (NFS) were measured before and after 6-month of PTX-treatment.
Results: The present study showed that PTX-treated patients significantly decreased hepatic levels of aminotransferase enzymes and non-invasive scores. Besides, after 6 months of treatment, PTX revealed improvement in hepatic fibrosis through a marked reduction in aspartate aminotransferase to platelet ratio (APRI) index, fibrosis-4 (FIB‐4) index, and NAFLD fibrosis score (NFS). Conversely, other biochemical markers showed a slightly significant change after PTX therapy. Moreover, PTX administration showed non-significant safety problems in these participants.
Conclusions: Patients treated with PTX revealed safety and efficacy in improving liver enzymes, lipid panel, and non-invasive fibrosis scores in NASH patients. In addition, our results indicated that PTX showed improvement in hepatic fibrosis scores, which reflected its anti-fibrotic activity.
Phase I Clinical Trial. Safety of Baricitinib to prevent respiratory insufficiency in oncohematological patients affected by Coronavirus Disease-19: BARCOVID19 study
Authors: Sanz-Linares Gabriela , Mussetti Alberto , Albasanz-Puig Adaia , Salvador Iñaki , Sureda Anna , Gudiol Carlota , Salazar Ramon , Marin Mar , García Margarita , Navarro Valentin , Haba Irma De la , Coma Eva , Dura Xavier , Fontanals Sandra , Serrano Gala , Cruz Claudia , Mañez Rafael , Moreno-González Gabriel 
Published: March 2023

Abstract
Background

Oncohematological patients, due to their secondary immunodeficiency, are at a higher risk of mortality related to COVID-19 infection. Baricitinib, a JAK2 inhibitor, has a dual effect in this context, reducing the inflammatory response to the virus and diminishing virus endocytosis.

Methods

This phase I safety run-in cohort study aimed to determine the dose-limiting toxicity of baricitinib in terms of the rate of serious events in oncohematological patients with COVID-19. The drug was administered on an inpatient basis at an oral dose of 4 mg daily for 5 to 7 days, associated with the institutional standard of care (SOC).

Results

Six patients with solid tumors or hematological malignancies were enrolled in the study. Sixty percent of the patients received active anticancer treatment at the time of inclusion. Lymphopenia and elevation of acute-phase reactants were the most frequent laboratory findings that improved during the treatment course. All patients received corticosteroids, but only 3 of them received remdesivir as the SOC. The most common adverse events were bacterial infections, including pneumonia, urinary tract infections, and bacteremia. The mortality rate due to disease progression and respiratory insufficiency is 33%. The severe adverse event rate was less than 33%, with no adverse events or mortality caused by baricitinib.

Conclusions

The results of the present study demonstrate that baricitinib is a safe treatment for patients with oncohematological diseases and COVID-19. However, its efficacy and superiority to standard treatment will require further testing in phases 2 and 3 trials.

Trial registration:

AEMPs: 20–0356 EudraCT: 2020-001789-12
Age and Sex-Related Comparison of Telemedicine Service Utilization During the COVID-19 Pandemic: A Retrospective Analysis
Authors: Wong Hubert , Razvi Yasmeen , Hamid Muhammad Akhter , Mistry Niraj , Filler Guido 
Published: March 2023

Abstract
Background
The COVID-19 pandemic has led to increased utilization of telemedicine services.
Methods
A retrospective analysis of all non-hospital-based medical healthcare services in Ontario from November 2019 to June 2021 was collected from the Ontario Health Insurance Plan (OHIP) billing database. Only fee-for-service billings were included in the present analysis. Coincident COVID-19 cases were obtained from Public Health Ontario. Comparisons were made based on age bracket, sex, telemedicine and in-person care.
Results
Billings for telemedicine services in Ontario increased from $1.7 million in November 2019 to $64 million in April 2020 and the proportions reached a mean peak of 72% in April 2020 and declined to 46% in June 2021. A positive correlation was found between the use of telemedicine and COVID-19 cases (p = 0.05). The age group with the highest proportion of telemedicine use was the 10–20-year-olds, followed by the 20–50-year-olds (61 ± 9.0%, 55 ± 7.3%, p = 0.01). Both age groups remained above 50% telemedicine services at the end of the study period. There is a persistent sex preference for females to adopt telemedicine (females 54.2 ± 8.0%, males 47.9 ± 7.7%, ANCOVA p = 0.05)
Conclusions
The use of telemedicine services remains at a high level across groups, particularly the 10–50-year-olds. There are clear age and sex preferences for using telemedicine. Studying these differences may provide insights into how the delivery of non-hospital-based medicine has changed during the COVID-19 pandemic.
A BERT-Based model: Improving Crime News Documents Classification through Adopting Pre-trained Language Models
Authors: Ali Ashour , Noah Shahrul Azman Mohd , Zakaria Lailatul Qadri 
Published: March 2023

Abstract
Text classification has played a key role in various fields, such as news classification, spam detection, and sentiment analysis. However, the classification of crime news continues to pose challenges, including low efficiency, low precision, and the scarcity of high-quality annotated data on a large scale. Using pre-trained language models, such as Bidirectional Encoder Representation from Transformers (BERT), has reduced the need for extensive amounts of labelled data in the categorization process. BERT boasts strong abilities in contextual representation and excels in text classification tasks, particularly when limited labelled data is present. A BERT-based pre-trained language model was applied to categorize crimes using information gathered from Malaysian online newspapers to overcome the shortage of high-quality, large-scale crime-related labelled data. The crime-related labelled dataset used for training this model was compiled from BERNAMA (Malaysian National News Agency) and manually labelled by crime investigation experts into 12 categories, including a non-crime class. The experiment results showed that the BERT-based model outperformed previous models and achieved the highest performance with an accuracy of 99.45%. This highlights the efficacy of BERT in classifying crime news, even with a small dataset.
Development of Inclined Applicators for Flattened Beam Intraoperative Radiotherapy
Authors: Kim Jeong Heon , Ahn Sohyun , Park Kwangwoo , Lee Rena , Kim Jin Sung 
Published: March 2023

Abstract
Purpose: We introduce a 3D-printed applicator for Intraoperative Radiation Therapy (IORT) using the INTRABEAM system. The applicator is designed to spare normal tissue, increase indications, and evaluate its clinical use in various intraoperative cases.
Methods: We designed and fabricated inclined applicators at 0° and 45° to generate flattened and unflattened beams and shield leakage dose to non-target regions. We evaluated the characteristics of the applicator, including dose uniformity, percentage depth dose, leakage, and dose rate of the beam.
Results: The uniformity of developed applicators at depths of 0, 2, 5, and 15 mm were as follows: 1.23, 1.28, 1.30, and 1.22 for a flattened beam, and 1.29, 1.32, 1.27, and 1.25 for an unflattened beam, respectively. No leakage dose was measured at a distance of 1 mm from the surface, and the measured dose rates after 3 min of irradiation for the flattened and unflattened beams of the 0° and 45° applicators were 51.0 and 52.9 cGy and 48.5 and 54.8 cGy, respectively.
Conclusions: The developed applicator demonstrated a uniform beam and leakage shielding to minimize radiation exposure to normal tissue. Customized applicators facilitated IORT treatment of chest and abdominal lesions near or on critical organs. The proposed method has been dose calibrated, and we proceeded with clinical application.
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in adrenal cortex cells
Authors: Nasri Atefeh , Sands Jade , Unniappan Suraj 
Published: March 2023

Abstract
Nucleobindin-derived peptides, nesfatin-1 [NESF-1] and nesfatin-1-like-peptide [NLP] have diverse roles in endocrine and metabolic regulation. While both peptides showed a stimulatory effect on the synthesis of POMC, the ACTH precursor in mouse corticotrophs, whether NESF-1 and NLP have any direct effect on glucocorticoid [GC] synthesis in the adrenal cortex remains unknown. The main aim of this study was to determine if NESF-1 and/or NLP act directly on adrenal cortex cells to regulate cortisol synthesis in vitro. Whether NLP injection affects stress-hormone gene expression in the adrenal gland and pituitary in vivo in mice was also assessed. In addition, cortisol synthetic pathway in Nucb1 knockout [KO] mice was studied. Human adrenal cortical [H295R] cells showed immunoreactivity for both NUCB1/NLP and NUCB2/NESF-1 using immunohistochemistry. NLP and NESF-1 decreased the expression of steroidogenic enzymes, cortisol synthesis and release through the AC/PKA/CREB pathway in H295R cells. Similarly, intraperitoneal injection of NLP in mice decreased the expression of enzymes involved in GC synthesis in the adrenal gland while increasing the expression of Pomc, Pcsk1 and Crhr1 in the pituitary. Moreover, the Mc2r mRNA level was enhanced in the adrenal gland samples of NLP injected mice. However, the global genetic disruption in Nucb1 did not affect most steroidogenic enzyme mRNAs, and Pomc, Pcsk2 and Crhr1 mRNAs in mice adrenal gland and pituitary gland, respectively. Collectively, these data provide the first evidence that NLP and NESF-1 directly decreased cortisol synthesis and secretion in vitro. NUCB peptides still might play its stimulatory effect on GC synthesis and secretion through their positive effects on ACTH-MC2R pathway in the pituitary.
Breast cancer and breast cancer screening use - beliefs and behaviours in a nationwide study in Malaysia
Authors: Tan Min Min , Jamil Aminatul Saadiah Abdul , Ismail Roshidi , Donnelly Michael , Su Tin Tin 
Published: March 2023

Abstract
Background
Many upper-middle-income countries (UMICs), including Malaysia, continue to face low breast cancer (BC) screening rates and patients with delayed presentation of BC. This study investigated the role of beliefs about BC and use of screening (e.g. beliefs about whether or not screening reduced the possibility of dying from BC).
Methods
A nationwide cross-sectional study was conducted in which a total of 813 women (aged ≥ 40 years old) were randomly selected and surveyed using the validated Awareness and Beliefs about Cancer (ABC) measure. The association between BC screening use, sociodemographic characteristics, and negative beliefs about BC screening were analysed using stepwise Poisson regressions.
Results
Seven out of ten Malaysian women believed that BC screening was necessary only if and when they started experiencing cancer symptoms. Women > 50 years and from households with more than one car or motorcycle were 1.6 times more likely to attend a mammogram or a clinical breast examination (mammogram: PR = 1.60, 95% CI = 1.19–2.14, CBE: PR = 1.61, 95%CI 1.29–1.99). Approximately one quarter of women (23%) reported anticipated anxiety about attending BC screening to the extent that they would avoid undergoing the procedure. Women who held negative beliefs about BC screening were 37% less likely to attend a mammogram (PR = 0.63, 95% CI = 0.42–0.94) and 24% less likely to seek a CBE (PR = 0.75, 95% CI = 0.60–0.95).
Conclusions
There is a need for public health strategies designed to change beliefs about BC screening among Malaysian women as a way of increasing uptake and impacting on late presentation and advanced cancer. The results provide insights about targeting of public health strategies – women with BC screening uptake-inhibiting beliefs tend to be under 50 years, in the lower income group (that do not own a car or a motorcycle) and more likely to be ethnic Malay or Indian (compared to Chinese-Malay).