bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthogonally Crosslinked Gelatin‐Norbornene Hydrogels for Biomedical Applications
Authors: Lin Chien‐Chi , Frahm Ellen , Afolabi Favour O. 
Published: September 2023

AbstractThe thiol‐norbornene photo‐click reaction has exceptionally fast crosslinking efficiency compared with chain‐growth polymerization at equivalent macromer contents. The orthogonal reactivity between norbornene and thiol/tetrazine permits crosslinking of synthetic and naturally derived macromolecules with modularity, including poly(ethylene glycol) (PEG)‐norbornene (PEGNB), gelatin‐norbornene (GelNB), among others. For example, collagen‐derived gelatin contains both cell adhesive motifs (e.g., Arg‐Gly‐Asp or RGD) and protease‐labile sequences, making it an ideal macromer for forming cell‐laden hydrogels. First reported in 2014, GelNB is increasingly used in orthogonal crosslinking of biomimetic matrices in various applications. GelNB can be crosslinked into hydrogels using multi‐functional thiol linkers (e.g., dithiothreitol (DTT) or PEG‐tetra‐thiol (PEG4SH) via visible light or longwave ultraviolet (UV) light step‐growth thiol‐norbornene reaction or through an enzyme‐mediated crosslinking (i.e., horseradish peroxidase, HRP). GelNB‐based hydrogels can also be modularly crosslinked with tetrazine‐bearing macromers via inverse electron‐demand Diels‐Alder (iEDDA) click reaction. This review surveys the various methods for preparing GelNB macromers, the crosslinking mechanisms of GelNB‐based hydrogels, and their applications in cell and tissue engineering, including crosslinking of dynamic matrices, disease modeling, and tissue regeneration, delivery of therapeutics, as well as bioprinting and biofabrication.
Hybrid Poly(β‐amino ester) Triblock Copolymers Utilizing a RAFT Polymerization Grafting‐From Methodology
Authors: Kasza Karolina , Elsherbeny Amr , Moloney Cara , Hardie Kim R. , Cámara Miguel , Alexander Cameron , Gurnani Pratik 
Published: September 2023

AbstractThe biocompatibility, biodegradability, and responsiveness of poly(β‐amino esters) (PBAEs) has led to their widespread use as biomaterials for drug and gene delivery. Nonetheless, the step‐growth polymerization mechanism that yields PBAEs limits the scope for their structural optimization toward specific applications because of limited monomer choice and end‐group modifications. Moreover, to date the post‐synthetic functionalization of PBAEs has relied on grafting‐to approaches, challenged by the need for efficient polymer–polymer coupling and potentially difficult post‐conjugation purification. Here a novel grafting‐from approach to grow reversible addition–fragmentation chain transfer (RAFT) polymers from a PBAE scaffold is described. This is achieved through PBAE conversion into a macromolecular chain transfer agent through a multistep capping procedure, followed by RAFT polymerization with a range of monomers to produce PBAE–RAFT hybrid triblock copolymers. Following successful synthesis, the potential biological applications of these ABA triblock copolymers are illustrated through assembly into polymeric micelles and encapsulation of a model hydrophobic drug, followed by successful nanoparticle (NP) uptake in breast cancer cells. The findings demonstrate this novel synthetic methodology can expand the scope of PBAEs as biomaterials.
Market orientation, organizational performance, and the mediating role of crowdsourcing in knowledge‐based firms
Authors: Devece Carlos , Llopis‐Albert Carlos , Palacios‐Marqués Daniel 
Published: September 2023

AbstractThis paper establishes the relationships between market orientation and crowdsourcing in knowledge‐based firms for improving their organizational performance. By understanding the relationships among these variables, firms are in a better position to tackle complex business and innovation problems faster and at a lower cost. Results from the Spanish biotechnology and telecommunications sectors show the relevance of social networks for a better adaptation to rapidly changing markets and increasing competitiveness.
A venue‐based approach to understanding advocacy by environmental nonprofits
Authors: Kagan Jennifer A. 
Published: September 2023

AbstractThis article explores the advocacy tactics that nonprofit organizations use to influence environmental policy across five venues: legislatures, regulatory agencies, courts, ballot boxes, and governors' offices. The literature on nonprofit advocacy has grown in recent years, with studies highlighting nonprofits' use of inside and outside tactics, but studies do not consistently link tactics to venues. This article addresses this gap by exploring advocacy tactics within specific venues. Bringing venues to the forefront leads to new insights about nonprofit advocacy, along with why advocates choose certain venues and tactics. Data are based on semi‐structured interviews with 24 environmental nonprofits across three states: Colorado, New Mexico, and Oklahoma. Results illuminate dynamics of nonprofit advocacy including the prevalence of nonprofit reliance on inside and hybrid tactics, insights regarding layers of outside tactics, the roles and implications of advocacy in courts and ballot measures, and nonprofits' infrequent use of venue shifting strategies.
Impact of hospitalization for vaso‐occlusive crisis on health‐related quality of life in children with sickle cell disease
Authors: Vuong Caroline , Moussa Ibtissame , van Muilekom Maud M. , Heijboer Harriët , Rettenbacher Eva , Haverman Lotte , Twisk Jos , Fijnvandraat Karin , Eckhardt Corien L. 
Published: September 2023

AbstractBackgroundSickle cell disease (SCD) is characterized by vaso‐occlusive crises (VOCs) that impair the health‐related quality of life (HRQoL). The aim of this study is to evaluate the impact of hospitalization for VOCs on HRQoL in children with SCD over time.MethodsIn this longitudinal cohort study, children aged 8–18 years diagnosed with SCD at the Amsterdam UMC were included between 2012 and 2021. HRQoL was annually measured as part of standard care using the Pediatric Quality of Life Inventory. The impact of hospitalization for VOC on HRQoL was evaluated using linear mixed models 3, 6, 9, and 12 months after hospitalization. The effect of frequency of hospitalization for VOC on HRQoL was evaluated over the last 12 months.ResultsIn total, 94 children with SCD were included with a median age of 11.8 years (interquartile range [IQR]: 9–14). Thirty‐seven patients (39%) had been hospitalized for a VOC. Hospitalization for VOC led to a decrease of 3.2–4.8 points in total HRQoL compared to patients without hospitalization, most pronounced 3 months after hospitalization. Recurrent admission for VOC in the last 12 months was associated with a decrease of 2.3 points in total HRQoL (p = .04). The most affected subscale was physical functioning.ConclusionThe adverse effects of hospitalization for VOC in children with SCD persist up to 12 months after hospitalization. After hospitalization for VOC, extra attention and support for its negative impact on HRQoL are recommended. This study also underlines the importance of systematically measuring HRQoL, allowing clinicians to intervene accordingly.
Application of sample displacement batch chromatography for fractionation of proteoforms
Authors: Hidayah Siti Nurul , Biabani Ali , Gaikwad Manasi , Nissen Paula , Voß Hannah , Riedner Maria , Schlüter Hartmut , Siebels Bente 
Published: September 2023

AbstractFractionation of proteoforms is currently the most challenging topic in the field of proteoform analysis. The need for considering the existence of proteoforms in experimental approaches is not only important in Life Science research in general but especially in the manufacturing of therapeutic proteins (TPs) like recombinant therapeutic antibodies (mAbs). Some of the proteoforms of TPs have significantly decreased actions or even cause side effects. The identification and removal of proteoforms differing from the main species, having the desired action, is challenging because the difference in the composition of atoms is often very small and their concentration in comparison to the main proteoform can be low. In this study, we demonstrate that sample displacement batch chromatography (SDBC) is an easy‐to‐handle, economical, and efficient method for fractionating proteoforms. As a model sample a commercial ovalbumin fraction was used, containing many ovalbumin proteoforms. The most promising parameters for the SDBC were determined by a screening approach and applied for a 10‐segment fractionation of ovalbumin with cation exchange chromatography resins. Mass spectrometry of intact proteoforms was used for characterizing the SDBC fractionation process. By SDBC, a significant separation of different proteoforms was obtained.
Aspects of Kink‐Like Structures in 2D Dilaton Gravity
Authors: Lima Francisco Cleiton E. , Almeida Carlos Alberto S. 
Published: September 2023

AbstractThe topological structures that arise from two‐dimensional (2D) models are relevant physically and the first step toward understanding more complex systems. In this work, one studies the kink‐like solutions of the matter field that emerge in a 2D dilaton gravity scenario. Considering this scenario, the linear stability of the matter field and the translational mode is examined. Due to the specific profile of the solutions found, a differential configurational complexity (DCC) analysis of the system is necessary to confirm the nature of the structures. Furthermore, the interforce and scattering process is studied, considering a pair of kink‐antikink‐like solutions in a fixed time ().
PDB‐BRE: A ligand–protein interaction binding residue extractor based on Protein Data Bank
Authors: Chen Shutao , Yan Ke , Liu Bin 
Published: September 2023

AbstractProteins typically exert their biological functions by interacting with other biomolecules or ligands. The study of ligand–protein interactions is crucial in elucidating the biological mechanisms of proteins. Most existing studies have focused on analyzing ligand–protein interactions, and they ignore the additional situational of inserted and modified residues. Besides, the resources often support only a single ligand type and cannot obtain satisfied results in analyzing novel complexes. Therefore, it is important to develop a general analytical tool to extract the binding residues of ligand–protein interactions in complexes fully. In this study, we propose a ligand–protein interaction binding residue extractor (PDB‐BRE), which can be used to automatically extract interacting ligand or protein‐binding residues from complex three‐dimensional (3D) structures based on the RCSB Protein Data Bank (RCSB PDB). PDB‐BRE offers a notable advantage in its comprehensive support for analyzing six distinct types of ligands, including proteins, peptides, DNA, RNA, mixed DNA and RNA entities, and non‐polymeric entities. Moreover, it takes into account the consideration of inserted and modified residues within complexes. Compared to other state‐of‐the‐art methods, PDB‐BRE is more suitable for massively parallel batch analysis, and can be directly applied for downstream tasks, such as predicting binding residues of novel complexes. PDB‐BRE is freely available at http://bliulab.net/PDB-BRE.
Galangin: A food‐derived flavonoid with therapeutic potential against a wide spectrum of diseases
Authors: Wang Daibo , Chen Junren , Pu Lin , Yu Lei , Xiong Fang , Sun Luyao , Yu Qian , Cao Xiaoyu , Chen Yan , Peng Fu , Peng Cheng 
Published: September 2023

AbstractGalangin is an important flavonoid with natural activity, that is abundant in galangal and propolis. Currently, various biological activities of galangin have been disclosed, including anti‐inflammation, antibacterial effect, anti‐oxidative stress and aging, anti‐fibrosis, and antihypertensive effect. Based on the above bioactivities, more and more attention has been paid to the role of galangin in neurodegenerative diseases, rheumatoid arthritis, osteoarthritis, osteoporosis, skin diseases, and cancer. In this paper, the natural sources, pharmacokinetics, bioactivities, and therapeutic potential of galangin against various diseases were systematically reviewed by collecting and summarizing relevant literature. In addition, the molecular mechanism and new preparation of galangin in the treatment of related diseases are also discussed, to broaden the application prospect and provide reference for its clinical application. Furthermore, it should be noted that current toxicity and clinical studies of galangin are insufficient, and more evidence is needed to support its possibility as a functional food.
Enhancing the Emission Rate of the Inherent Silicon‐Vacancy Center Using Optimized Multipolar Moments in a Silicon Carbide Metasurface
Authors: Vashist Vivek , Khokhar Megha , Inam Faraz A. , Nair Rajesh V. 
Published: September 2023

AbstractSilicon carbide (SiC) hosts various color centers with emission lines from visible to near‐infrared, with promising applications in quantum communication. Metasurfaces made using SiC can enhance the emission rate of inherent color centers to achieve on‐demand single photon emission with a high emission rate. This is possible by engineering the amplitude and phase of the excited multipolar scattering moments in metasurfaces. The numerical simulations and analytical calculations are used to study the emission rate enhancement from an embedded single silicon vacancy () center in SiC metasurface. The optimized metasurface balances multipolar moments at the zero‐phonon line wavelength of 862 nm with 40 times field intensity confinement. The confinement provides substantial emission rate enhancement for the center, making it a bright single photon emitter at 862 nm. The significant emission enhancement offers new insights into the metasurface to achieve on‐demand single‐photon sources and efficient spin–photon interfaces.
A high‐efficiency frequency synchronization scheme for low Earth orbit satellite communications based on dynamic game theory
Authors: Liu Wen , Cai Wei , Liu Lizhe , Wang Dongdong , Lin Wenliang , Wang Ke , Deng Zhongliang , Deng Yaohua , Wan Da , Dong Zewen , Hu Junhe 
Published: September 2023

SummaryThe rapid development of satellite internet networks has given rise to a new vision for the sixth generation of networking technology. However, the Doppler effect is relatively serious in satellite internet networks because a satellite moves quickly relative to a ground terminal. Therefore, there is an urgent need to study intelligent and dynamic synchronization methods to solve the problem of the rapidly changing Doppler frequency offset. Traditional methods do not consider the impact of spatial changes and typically focus on enhancing the estimation range or accuracy. We analyze various scenarios under phased array beam hopping and establish constraints between the terminal location, satellite ephemeris, subsatellite point track, elevation angle, and carrier frequency offset. We introduce dynamic game theory into frequency synchronization to optimize multiple Doppler estimation performance under rapidly changing channel conditions. We take the combination of carrier frequency offset estimation algorithm strategies at the current moment as the game entity. Simulation results demonstrate that the proposed method can achieve an estimation accuracy of 100 Hz and an estimation range of ±800 kHz. During the onboard test, the probability of achieving complete synchronization (when the synchronization success rate is 1) is 0.65, which is much higher than the 0.15 of the single method.
Self‐powered broadband kesterite photodetector with ultrahigh specific detectivity for weak light applications
Authors: Liang Guang‐Xing , Li Chuan‐Hao , Zhao Jun , Fu Yi , Yu Zi‐Xuan , Zheng Zhuang‐Hao , Su Zheng‐Hua , Fan Ping , Zhang Xiang‐Hua , Luo Jing‐Ting , Ding Liming , Chen Shuo 
Published: September 2023

AbstractKesterite Cu2ZnSn(S,Se)4 (CZTSSe) is a promising candidate for photodetector (PD) applications thanks to its excellent optoelectronic properties. In this work, a green solution‐ processed spin coating and selenization‐processed thermodynamic or kinetic growth of high‐quality narrow bandgap kesterite CZTSSe thin film is developed. A self‐powered CZTSSe/CdS thin‐film PD is then successfully fabricated. Under optimization of light absorber and heterojunction interface, especially tailoring the defect and carrier kinetics, it can achieve broadband response from 300 to 1300 nm, accompanied with a high responsivity of 1.37 A/W, specific detectivity (D*) up to 4.0 × 1014 Jones under 5 nW/cm2, a linear dynamic range (LDR) of 126 dB, and a maximum Ilight/Idark ratio of 1.3 × 108 within the LDR, and ultrafast response speed (rise/decay time of 16 ns/85 ns), representing the leading‐level performance to date, which is superior to those of commercial and well‐researched photodiodes. Additionally, an imaging system with a 905 nm laser is built for weak light response evaluation, and can respond to 718 pW weak light and infrared imaging at a wavelength as low as 5 nW/cm2. It has also been employed for photoplethysmography detection of pulsating signals at both the finger and wrist, presenting obvious arterial blood volume changes, demonstrating great application potential in broadband and weak light photodetection scenarios.
PDE5 inhibitor drugs for use in dementia
Authors: Hainsworth Atticus H. , Arancio Ottavio , Elahi Fanny M. , Isaacs Jeremy D. , Cheng Feixiong 
Published: September 2023

AbstractAlzheimer's disease and related dementias (ADRD) remain a major health‐care challenge with few licensed medications. Repurposing existing drugs may afford prevention and treatment. Phosphodiesterase‐5 (PDE5) is widely expressed in vascular myocytes, neurons, and glia. Potent, selective, Food and Drug Administration–approved PDE5 inhibitors are already in clinical use (sildenafil, vardenafil, tadalafil) as vasodilators in erectile dysfunction and pulmonary arterial hypertension. Animal data indicate cognitive benefits of PDE5 inhibitors. In humans, real‐world patient data suggest that sildenafil and vardenafil are associated with reduced dementia risk. While a recent clinical trial of acute tadalafil on cerebral blood flow was neutral, there may be chronic actions of PDE5 inhibition on cerebrovascular or synaptic function. We provide a perspective on the potential utility of PDE5 inhibitors for ADRD. We conclude that further prospective clinical trials with PDE5 inhibitors are warranted. The choice of drug will depend on brain penetration, tolerability in older people, half‐life, and off‐target effects.HIGHLIGHTS
Potent phosphodiesterase‐5 (PDE5) inhibitors are in clinical use as vasodilators.
In animals PDE5 inhibitors enhance synaptic function and cognitive ability.
In humans the PDE5 inhibitor sildenafil is associated with reduced risk of Alzheimer's disease.
Licensed PDE5 inhibitors have potential for repurposing in dementia.
Prospective clinical trials of PDE5 inhibitors are warranted.
Teaching with Cuentos Combativos: Reading for Decolonial Futures
Authors: Torres Francisco Luis , Medina Carmen Liliana 
Published: September 2023

AbstractTransnational children's texts can bring communities together, forcing us to reflect critically on our past, present, and future, and pushing us to action. In this column, we propose that texts that do this form of activist work are cuentos combativos and that all teachers and researchers can leverage cuentos combativos for critical reflection, ReconoceR, and action for justice.
A Comparison of Self-reported Condomless Sex and Yc-DNA Biomarker Data from Young Women Engaged in High Risk Sexual Activity in Kampala, Uganda
Authors: Boering Pippa , Seeley Janet , Buule Joshua , Kamacooko Onesmus , King Rachel 
Published: September 2023

AbstractReporting of condom-use can limit researchers’ understanding of high-risk sexual behaviours. We compared self-reported condom-use with the Yc-DNA biomarker data and investigated potential factors influencing participation in, and reporting of, sexual behaviours. Self-reported data were collected using Audio Computer Assisted Self Interviews (ACASI) and samples for Yc-DNA biomarker were collected using self-administered and health worker-collected vaginal swabs from 644 women (aged 15–24 years) who were not living with HIV. Yc-DNA results and interview data were compared using McNemar-Bowker Analysis and Cohen’s Kappa. Test statistics for Yc-DNA biomarker were calculated. Log Binomial models for Yc-DNA and self-reported results were conducted to assess for association. We found strong evidence (p < 0.001) for a difference between Yc-DNA and self-reported results. 13.7% of participants reported consistent condom-use with all partners, regardless of HIV status. Self-reported condom-use was discordant in 50.0% (n = 206) of cases, when compared to Yc-DNA results. Positive Yc-DNA results were found to be associated with older age (RR 1.36; 95%CI 1.04, 1.76 p = 0.023). Self-reported condom-use with partners with unknown HIV status was associated with higher education (RR 0.76; 95%CI 0.58,0.99 p = 0.043). Sensitivity analysis did not determine difference between methods for controlling for missing data. We found significant under-reporting of condomless sex in the self-reported data when compared to Yc-DNA results.
Penalized enhanced portfolio replication with asymmetric deviation measures
Authors: Torri Gabriele , Giacometti Rosella , Paterlini Sandra 
Published: September 2023

AbstractPassive investment strategies, such as those implemented by Exchange Traded Funds (ETFs), have gained increasing popularity among investors. In this context, smart beta products promise to deliver improved performance or lower risk through the implementation of systematic investing strategies, and they are also typically more cost-effective than traditional active management. The majority of research on index replication focuses on minimizing tracking error relative to a benchmark index, implementing constraints to improve performance, or restricting the number of assets included in portfolios. Our focus is on enhancing the benchmark through a limited number of deviations from the benchmark. We propose a range of innovative investment strategies aimed at minimizing asymmetric deviation measures related to expectiles and quantiles, while also controlling for the deviation of portfolio weights from the benchmark composition through penalization. This approach, as compared to traditional minimum tracking error volatility strategies, places a greater emphasis on the overall risk of the portfolio, rather than just the risk relative to the benchmark. The use of penalization also helps to mitigate estimation risk and minimize turnover, as compared to strategies without penalization. Through empirical analysis using simulated and real-world data, we critically examine the benefits and drawbacks of the proposed strategies in comparison to state-of-the-art tracking models.