bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation biomarkers are associated with the incidence of cardiovascular disease: a meta-analysis
Authors: Liu Yifei , Guan Suzhen , Xu Haiming , Zhang Na , Huang Min , Liu Zhihong 
Published: July 2023

BackgroundInflammation is a risk factor for cardiovascular disease (CVD), and particular inflammatory parameters can be used to predict the incidence of CVD. The aim of this study was to assess the association between fibrinogen (FIB), interleukin-6 (IL-6), C-reactive protein (CRP) and galectin-3 (Gal-3) and the risk of cardiovascular disease using meta-analysis.MethodsPubMed, Embase, Scopus, and Web of Science databases were searched with the appropriate strategies to identify observational studies relevant to this meta-analysis. A random-effects model was used to combine inflammation factor-associated outcomes and cardiovascular disease outcomes, except in the case of galectin-3, where a fixed-effects model was used because of less heterogeneity. Location, age, type of cardiovascular disease, and sample size factors were used to explore heterogeneity in stratification and metaregression for subgroup analysis. A case-by-case literature exclusion approach was used for sensitivity analysis. The funnel plot and Begg's test were combined to assess publication bias.ResultsThirty-three papers out of 11,456 were screened for inclusion in the analysis. Four inflammation biomarkers were significantly associated with the development of CVD: FIB (OR: 1.21, 95% CI: 1.15–1.27, P &lt; 0.001; HR: 1.04, 95% CI: 1.00–1.07, P &lt; 0.05), IL-6 (HR: 1.16, 95% CI: 1.10–1.22, P &lt; 0.001), CRP (OR: 1.25, 95% CI: 1.15–1.35, P &lt; 0.001; HR: 1.20, 95% CI: 1.14–1.25, P &lt; 0.001) and Gal-3 (HR: 1.09, 95% CI: 1.05–1.14, P &lt; 0.001). Location factors help explain the source of heterogeneity, and there is publication bias in the Gal-3 related literature.ConclusionTaken together, the current research evidence suggests that high levels of fibrinogen, interleukin-6, C-reactive protein and galectin-3 are risk factors for cardiovascular disease and can be used as biomarkers to predict the development of cardiovascular disease to some extent.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier: CRD42023391844.
Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome
Authors: Pierotti Laura , Pardi Elena , Dinoi Elisa , Piaggi Paolo , Borsari Simona , Della Valentina Simone , Sardella Chiara , Michelucci Angela , Caligo Maria Adelaide , Bogazzi Fausto , Marcocci Claudio , Cetani Filomena 
Published: July 2023

BackgroundMultiple Endocrine Neoplasia type 1 is a rare genetic syndrome mainly caused by mutations of MEN1 gene and characterized by a combination of several endocrine and non-endocrine manifestations. The objective of this study was to describe cutaneous lesions and other non-endocrine manifestations of MEN1 in a cohort of patients with familial (F) and sporadic (S) MEN1, compare the prevalence of these manifestations between the two cohorts, and investigate the correlation with MEN1 mutation status.MethodsWe collected phenotypic and genotypic data of 185 patients with F-MEN1 and S-MEN1 followed from 1997 to 2022. The associations between F-MEN1 and S-MEN1 or MEN1 mutation-positive and mutation-negative patients and non-endocrine manifestations were determined using chi-square or Fisher’s exact tests or multivariate exact logistic regression analyses.ResultsThe prevalence of angiofibromas was significantly higher in F-MEN1 than in S-MEN1 in both the whole (p &lt; 0.001) and index case (p = 0.003) cohorts. The prevalence of lipomas was also significantly higher in F-MEN1 than in S-MEN1 (p = 0.009) and in MEN1 mutation-positive than in MEN1 mutation-negative (p = 0.01) index cases. In the whole cohort, the prevalence of lipomas was significantly higher in MEN1 mutation-positive compared to MEN1 mutation-negative patients (OR = 2.7, p = 0.02) and in F-MEN1 than in S-MEN1 (p = 0.03), only after adjustment for age. No significant differences were observed for the other non-endocrine manifestations between the two cohorts. Hibernoma and collagenoma were each present in one patient (0.5%) and meningioma and neuroblastoma in 2.7% and 0.5%, respectively. Gastric leiomyoma was present in 1.1% of the patients and uterine leiomyoma in 14% of women. Thyroid cancer, breast cancer, lung cancer, basal cell carcinoma, melanoma, and colorectal cancer were present in 4.9%, 2.7%, 1.6%, 1.6%, 2.2%, and 0.5% of the whole series, respectively.ConclusionsWe found a significantly higher prevalence of angiofibromas and lipomas in F-MEN1 compared with S-MEN1 and in MEN1 mutation-positive compared to MEN1 mutation-negative patients. In patients with one major endocrine manifestation of MEN1, the presence of cutaneous lesions might suggest the diagnosis of MEN1 and a possible indication for genetic screening.
A network approach to define the predictive role of immune profile on tumor response and toxicity of anti PD-1 single agent immunotherapy in patients with solid tumors
Authors: Mezi Silvia , Pomati Giulia , Fiscon Giulia , Amirhassankhani Sasan , Zizzari Ilaria Grazia , Napoletano Chiara , Rughetti Aurelia , Rossi Ernesto , Schinzari Giovanni , Tortora Giampaolo , Lanzetta Gaetano , D’Amati Giulia , Nuti Marianna , Santini Daniele , Botticelli Andrea 
Published: July 2023

BackgroundThe immune profile of each patient could be considered as a portrait of the fitness of his/her own immune system. The predictive role of the immune profile in immune-related toxicities (irAEs) development and tumour response to treatment was investigated.MethodsA prospective, multicenter study evaluating, through a multiplex assay, the soluble immune profile at the baseline of 53 patients with advanced cancer, treated with immunotherapy as single agent was performed. Four connectivity heat maps and networks were obtained by calculating the Spearman correlation coefficients for each group: responder patients who developed cumulative toxicity (R-T), responders who did not develop cumulative toxicity (R-NT), non-responders who developed cumulative toxicity (NR-T), non-responders who did not develop cumulative toxicity (NR-NT).ResultsA statistically significant up-regulation of IL-17A, sCTLA4, sCD80, I-CAM-1, sP-Selectin and sEselectin in NR-T was detected. A clear loss of connectivity of most of the soluble immune checkpoints and cytokines characterized the immune profile of patients with toxicity, while an inversion of the correlation for ICAM-1 and sP-selectin was observed in NR-T. Four connectivity networks were built for each group. The highest number of connections characterized the NR-T.ConclusionsA connectivity network of immune dysregulation was defined for each subgroup of patients, regardless of tumor type. In patients with the worst prognosis (NR-T) the peculiar connectivity model could facilitate their early and timely identification, as well as the design of a personalized treatment approach to improve outcomes or prevent irAEs.
Brief report: can COVID-19 infection trigger rheumatoid arthritis-associated autoimmunity in individuals at risk for the disease? A nested cohort study
Authors: Lamacchia Celine , Gilbert Benoit , Studer Olivia , Lauper Kim , Finckh Axel 
Published: July 2023

ObjectivesTo investigate the association between severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) infection and subsequent development of autoimmunity or pre-clinical manifestations associated with rheumatoid arthritis (RA) in at risk population.MethodsThis is a nested study within a prospective cohort of first-degree relatives of RA patients (RA-FDR). Participants are tested for RA-associated autoantibodies (anti-citrullinated peptide antibodies (ACPA)/rheumatoid factor (RF)) and clinical signs and symptoms suggestive of early disease. SARS-CoV-2 infections were self-reported between March 2020 and January 2023. All individuals with a pre-pandemic (sample 1) and a post-pandemic sample (sample 2) were included in the analysis. The exposure of interest was self-reported SARS-CoV-2 infection. The primary outcome was a clinically significant change in RA-associated autoantibody serum titers. Secondary outcomes included: becoming seropositive, becoming symptomatic, developing classifiable RA.ResultsAmong 168 RA-FDRs, 109 reported a SARS-CoV-2 infection between sample 1 and sample 2. During this period, 2 RA-FDRs (1.2%) became anti-CCP2 seropositive, none became anti-CCP3 IgG positive, 6 (3.6%) became RF IgM seropositive, 1 became (0.6%) RF IgA seropositive, 19 (11.3%) became symptomatic and none developed classifiable RA. SARS-CoV-2 infection was not significantly associated with increases in RA autoantibody titers or with secondary outcomes.ConclusionWe could not detect an association between SARS-CoV-2 infection and subsequent development of RA-associated autoimmunity, nor signs or symptoms of RA in an at risk population. These findings do not support the hypothesis that SARS-CoV-2 infections triggers the immune onset of RA.
Repetitive transcranial magnetic stimulation for cerebellar ataxia: a systematic review and meta-analysis
Authors: Yin Lianjun , Wang Xiaoyu , Chen Lianghua , Liu Dandan , Li Haihong , Liu Zhaoxing , Huang Yong , Chen Junqi 
Published: July 2023

BackgroundRepetitive transcranial magnetic stimulation, a non-invasive brain stimulation technique, can manage cerebellar ataxia (CA) by suppressing cerebral cortical excitability. Hence, this study aimed to summarize the efficacy and safety of rTMS for CA patients by meta-analysis.MethodsThe PubMed, Embase, Web of Science, and Cochrane Library databases were searched for eligible studies published till 20 May 2023. Weighted mean difference (MD) and 95% confidence intervals (CIs) were used to assess the effect of rTMS treatment. Additionally, the quality of the included studies and the risk of bias were evaluated using the Physiotherapy Evidence Database (PEDro) scale.ResultsOverall, eight studies involving 278 CA patients were included in this meta-analysis. rTMS could significantly improve the Scale for the Assessment and Rating of Ataxia (SARA) (MD: −2.00; 95% CI: −3.97 to −0.02, p = 0.05), International Cooperative Ataxia Rating Scale (ICARS) (MD: −3.96; 95% CI: −5.51 to −2.40, p &lt; 0.00001), Timed Up-and-Go test (TUG) (MD: −1.54; 95% CI: −2.24 to −0.84, p &lt; 0.0001), 10-m walk test (10 MWT) (MD10−m steps: −2.44; 95% CI: −4.14 to −0.73, p = 0.005), and Berg Balance Scale (BBS) (MD: 2.59; 95% CI: 1.15–4.03, p = 0.0004) as compared to sham stimulation. Active rTMS was not significantly different from sham rTMS in changing the duration (MD10−m time: −1.29; 95% CI: −7.98 to 5.41, p = 0.71). No severe adverse events were observed in both sham stimulation and active rTMS groups.ConclusionThis meta-analysis provides limited evidence that rTMS may be beneficial in treating CA patients. However, these findings should be treated with caution due to the limitations of the smaller sample size and the inconsistent approach and target of rTMS treatment. Therefore, more large-scale RCTs are required to further validate our analytical findings.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=295726, identifier: CRD42022295726.
The German version of the brief affective neuroscience personality scales including a LUST scale (BANPS–GL)
Authors: Fuchshuber Jürgen , Prandstätter Theresa , Andres Deborah , Roithmeier Lisa , Schmautz Beate , Freund Anton , Schwerdtfeger Andreas , Unterrainer Human-Friedrich 
Published: July 2023

ObjectivesThis study presents the German version of the Brief Affective Neuroscience Personality Scales (BANPS), which includes an additional subscale for the dimension LUST. The BANPS represents a shortened version of the Affective Neuroscience Personality Scales (ANPS), a self–report instrument to assess individual dispositions toward primary emotional systems as proposed by Jaak Panksepp.MethodsIn a large sample (N= 926), the reliability and various facets of validity of the German translation of the BANPS were examined together with the newly included LUST scale. The BANPS–GL was related to the Big Five Inventory (BFI) and Sexual Sensation Seeking Scale (SSSS) and analyzed via confirmatory factor analysis (CFA).ResultsOverall, the BANPS–GL exhibited reliabilities ranging from McDonald’s ω = 0.70 (CARE) to α = 0.86 (SADNESS) and plausible correlations with external criteria. For CFA a correlated 7–factor model demonstrated good fit [TLI = 0.95; RMSEA = 0.04 (90% CI: 0.04, 0.05); SRMR = 0.06]. A similar fit was demonstrated for a 2–higher–factor model [TLI = 0.93; RMSEA = 0.05 (90% CI: 0.05, 0.06); SRMR = 0.07].ConclusionIn broad agreement with the results of the original English version, the BANPS–GL showed good reliability and acceptable factorial validity, and overall improved the psychometric properties of the original long form. Finally, the inclusion of the dimension LUST allows for a complete coverage of the primary emotion dispositions as originally conceptualized by Panksepp.
Computerized working memory training for hypertensive individuals with executive function impairment: a randomized clinical trial
Authors: Paradela Regina Silva , Cabella Brenno , Nucci Mariana Penteado , Ferreira Naomi Vidal , Torres Laura Aló , Martino Luiza Menoni , Consolim-Colombo Fernanda Marciano , Bortolotto Luiz Aparecido , da Costa Danielle Irigoyen , Irigoyen Maria Claudia 
Published: July 2023

BackgroundHypertension is associated with working memory (WM) impairment. However, the benefits of Cogmed WM training for the hypertensive population are unknown. Therefore, we aimed to evaluate Cogmed’s effects on the WM performance of hypertensive individuals with executive function (EF) impairment.MethodsWe included 40 hypertensive patients (aged 40–70 years, 68% female) with EF impairment. They were randomized in a 1:1 ratio to receive 10 weeks of adaptive Cogmed training or a non-adaptive control training based on online games. The primary outcome was the WM performance. The secondary outcomes were verbal memory, visuospatial ability, executive function, global cognition, and the neuronal activity measured using functional magnetic resonance imaging (fMRI) under two WM task conditions: low (memorization of 4 spatial locations) and high (memorization of 6 spatial locations). An intention-to-treat (ITT) and per-protocol (PP) analysis were performed.ResultsCogmed did not show a significant effect on WM or any other cognitive outcome post-training. However, under the WM-low load and WM-high load conditions of the fMRI, respectively, the Cogmed group had an activation decrease in the right superior parietal lobe (ITT and PP analyses) and left inferior frontal lobe (PP analysis) in comparison to the control group.ConclusionThe Cogmed showed no effects on the WM performance of hypertensive individuals with EF impairment. However, activation decreases were observed in frontoparietal areas related to the WM network, suggesting a more efficient neuronal activity after training.
Parenting styles and obsessive-compulsive symptoms in college students: the mediating role of perfectionism
Authors: Hu Po , Liang Pengwei , Liu Xiaoyan , Ouyang Yuting , Wang Jianping 
Published: July 2023

IntroductionObsessive-compulsive symptoms is a common psychological phenomenon among early adulthood college students, which are closely related to their parents’ parenting styles. Theoretical and some empirical studies have suggested the mediating role of perfectionism in this process, but this has not been confirmed, and the binary perspective of positive-negative perfectionism has not been addressed in this issue.MethodsThis study aimed to investigate the mediating role of perfectionism in the relationship between parenting styles and obsessive-compulsive symptoms among college students. A total of 661 college students participated in this study.ResultsNegative perfectionism mediated the relationship between negative parenting style and obsessive-compulsive symptoms among college students. Negative parenting style predicted obsessive-compulsive symptoms through its positive predictive effect on negative perfectionism. However, the mediating effect of positive perfectionism was not significant in this process.DiscussionThis study provides further evidence of the mechanisms underlying the occurrence of obsessive-compulsive symptoms, and offers new ideas for interventions for OCD.
Common mental disorders and associated factors among Ethiopian prisoners: a systematic review and meta-analysis
Authors: Fentahun Setegn , Takelle Girmaw Medfu , Rtbey Gidey , Andualem Fantahun , Tinsae Techilo , Tadesse Gebresilassie , Melkam Mamaru 
Published: July 2023

BackgroundCommon mental disorders are a major public health concern in the world and negatively influence people’s psychological, physical, economic, and overall well-being. Since prisoners live with restricted freedom and lack regular social interaction like communication with family and friends, the prevalence of common mental disorders is frequently found to be higher among prisoners compared to the general population. Therefore, this systematic review and meta-analysis aimed to estimate the pooled prevalence of common mental disorders and their associated factors among prisoners in Ethiopia.MethodsThe primary published studies were searched by using different databases like PubMed, Google Scholar, CINHAL, and African Journal Online. A total of eight primary articles that assessed the prevalence and associated factors of common mental disorders among Ethiopian prisoners were included in this systematic review and meta-analysis. The data were extracted using the data extraction format in a Microsoft Excel spreadsheet and exported to Stata version 14 for further analysis. The statistical heterogeneity was assessed by the I2 test. Due to the presence of heterogeneity among included studies, a random effect meta-analysis model was employed. Egger’s weighted regression test and funnel plots were used to check the presence of publication bias.ResultsA total of 8 primary studies with 3,585 study participants were included in this systematic review and meta-analysis. The pooled prevalence of common mental disorders among Ethiopian prisoners was 62.29% with a 95% CI (50.94, 73.65). The subgroup analysis based on regional state revealed that the pooled prevalence of common mental disorders in Amhara, Oromia, and the other two regions (Addis Ababa and SNNPR) was 72.4, 50.23, and 54.25%, respectively. History of mental illness (AOR = 6.21, 95% CI: 3.27, 11.80), poor social support (AOR = 3.90, 95% CI: 1.45, 10.51), and traumatic life events (AOR = 3.63, 95% CI: 1.04, 12.73) were significantly associated with a common mental disorder in this review.ConclusionIn this systematic review and meta-analysis, the pooled prevalence of common mental disorders among prisoners was high. Therefore, improving the delivery of mental health services in correctional institutions has a major contribution to the reduction of the disorder, and incarcerated people require more attention and early intervention for common mental disorders.
Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Authors: Isma Gabriella E. , Rämgård Margareta , Enskär Karin 
Published: July 2023

IntroductionAccording to the Convention on the Rights of the Child, all children have the right to health. Since good health is a decisive factor for children’s future, investing in children’s health is important, especially children from vulnerable areas. The purpose of this study was to investigate the perceptions of health among school-aged children from socially vulnerable areas.MethodsThe study has an explorative mixed-method design with a participatory and inductive approach based on focus group interviews with children and youth leaders, respectively, at Multi-activity Centers in three of the vulnerable areas in Malmö Municipality, as well as results from the Multi-activity Centers’ own questionnaire. The data has been analyzed with inductive and deductive content analysis.ResultsThe children and the youth leaders described health in terms of well-being, participation, and activity. Well-being included feeling good and safe, having a healthy body, and having fun by doing things together with friends and leaders. Participating in activities was described as having a feeling of involvement, being able to have an influence on the organization of the activities and participating on one’s own terms.DiscussionThe result of this study shows that participating in activities increases the child’s sense of well-being.
Volatility of the COVID-19 vaccine hesitancy: sentiment analysis conducted in Brazil
Authors: Machado Júnior Celso , Mantovani Daielly Melina Nassif , de Sandes-Guimarães Luísa Veras , Romeiro Maria do Carmo , Furlaneto Cristiane Jaciara , Bazanini Roberto 
Published: July 2023

BackgroundVaccine hesitancy is a phenomenon that can interfere with the expansion of vaccination coverage and is positioned as one of the top 10 global health threats. Previous studies have explored factors that affect vaccine hesitancy, how it behaves in different locations, and the profile of individuals in which it is most present. However, few studies have analyzed the volatility of vaccine hesitancy.ObjectiveIdentify the volatility of vaccine hesitancy manifested in social media.MethodsTwitter’s academic application programming interface was used to retrieve all tweets in Brazilian Portuguese mentioning the COVID-19 vaccine in 3 months (October 2020, June 2021, and October 2021), retrieving 1,048,576 tweets. A sentiment analysis was performed using the Orange software with the lexicon Multilingual sentiment in Portuguese.ResultsThe feelings associated with vaccine hesitancy were volatile within 1 month, as well as throughout the vaccination process, being positioned as a resilient phenomenon. The themes that nurture vaccine hesitancy change dynamically and swiftly and are often associated with other topics that are also affecting society.ConclusionPeople that manifest the vaccine hesitancy present arguments that vary in a short period of time, what demand that government strategies to mitigate vaccine hesitancy effects be agile and counteract the expressed fear, by presenting scientific arguments.