bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of survival in advanced oral cancers after salvage surgery with free tissue flap reconstruction
Authors: Hafström Anna , Wahlberg Peter , Klasson Stina , Greiff Lennart , Sjövall Johanna 
Published: March 2023

Abstract
Objective
To identify prognostic factors for patients with advanced persistent, recurrent, or 2nd primary oral cavity squamous cell carcinoma (OCSCC) potentially unsuitable for salvage surgery with free tissue flap (FTF) reconstruction.

Materials and methods
A population-based cohort of 83 consecutive patients with advanced OCSCC who underwent salvage surgery with FTF reconstruction at a tertiary referral centre between 1990 and 2017. Retrospective uni- and multivariable analyses were performed to identify factors affecting all-cause mortality (ACM), i.e., overall survival (OS), as well as disease-specific mortality (DSM), i.e., disease-specific survival (DSS) after salvage surgery.

Results
Median disease-free interval until recurrence was 15 months with recurrent stage I/II in 31% and III/IV in 69%. Median age at salvage surgery was 67 years (range 31–87) and the median follow-up (alive patients) 126 months. At 2, 5, and 10 years after salvage surgery, respectively, DSS rates were 61%, 44%, and 37% and OS rates 52%, 30%, and 22%. Median DSS was 26 and OS 43 months. Multivariable analysis identified recurrent clinical regional (cN-plus) disease [HR 3.57; p < .001] and elevated gamma-glutamyl transferase (GGT) [HR 3.30; p = .003] as independent pre-salvage predictors for poor OS after salvage, whereas initial cN-plus [HR 2.07; p = .039] and recurrent cN-plus disease [HR 5.14; p < .001] predicted poor DSS. Among post-salvage factors, extranodal extension according to histopathology [HR ACM 6.11; HR DSM 9.99; p < .001] as well as positive [HR ACM 4.98; DSM 7.51; p < 0.001] and narrow surgical margins [HR ACM 2.12; DSM HR 2.80; p < 0.01] emerged as independent factors for poor survival.

Conclusion
While salvage surgery with FTF reconstruction is the primary curative option for patients with advanced recurrent OCSCC, the present findings may help guide discussions with patients who have advanced recurrent regional disease and high GGT preoperatively, especially if there is a small chance of reaching surgical radicality.
Few-shot learning via graph embeddings with convolutional networks for low-data molecular property prediction
Authors: Torres Luis , Arrais Joel P. , Ribeiro Bernardete 
Published: March 2023

AbstractGraph neural networks and convolutional architectures have proven to be pivotal in improving the prediction of molecular properties in drug discovery. However, this is fundamentally a low data problem that is incompatible with regular deep learning approaches. Contemporary deep networks require large amounts of training data, which severely limits the prediction of new molecular entities from limited available data. In this paper, we address the challenge of low data in molecular property prediction by: (1) defining a set of deep learning architectures that accept compound chemical structures in the form of molecular graphs, (2) creating a few-shot learning strategy across graph neural networks and convolutional neural networks to leverage the rich information of graph embeddings, and (3) proposing a two-module meta-learning framework to learn from task-transferable knowledge and predict molecular properties on few-shot data. Furthermore, we conduct multiple experiments on two benchmark multiproperty datasets to demonstrate a superior performance over conventional graph-based baselines. ROC-AUC results for 10-shot experiments show an average improvement of $$+11.37\%$$

+
11.37
%

on Tox21 and $$+0.53\%$$

+
0.53
%

on SIDER, which are representative small-sized biological datasets for molecular property prediction.
Infection with acanthocephalans increases tolerance of Gammarus roeselii (Crustacea: Amphipoda) to pyrethroid insecticide deltamethrin
Authors: Kochmann Judith , Laier Melanie , Klimpel Sven , Wick Arne , Kunkel Uwe , Oehlmann Jörg , Jourdan Jonas 
Published: March 2023

AbstractCrustacean amphipods serve as intermediate hosts for parasites and are at the same time sensitive indicators of environmental pollution in aquatic ecosystems. The extent to which interaction with the parasite influences their persistence in polluted ecosystems is poorly understood. Here, we compared infections of Gammarus roeselii with two species of Acanthocephala, Pomphorhynchus laevis, and Polymorphus minutus, along a pollution gradient in the Rhine-Main metropolitan region of Frankfurt am Main, Germany. Prevalence of P. laevis was very low at the unpolluted upstream reaches (P ≤ 3%), while higher prevalence (P ≤ 73%) and intensities of up to 9 individuals were found further downstream—close to an effluent of a large wastewater treatment plant (WWTP). Co-infections of P. minutus and P. laevis occurred in 11 individuals. Highest prevalence of P. minutus was P ≤ 9% and one parasite per amphipod host was the maximum intensity recorded. In order to assess whether the infection affects survival in the polluted habitats, we tested the sensitivity of infected and uninfected amphipods towards the pyrethroide insecticide deltamethrin. We found an infection-dependent difference in sensitivity within the first 72 h, with an effect concentration (24 h EC50) of 49.8 ng/l and 26.6 ng/l for infected and uninfected G. roeselii, respectively. Whereas final host abundance might partially explain the high prevalence of P. laevis in G. roeselii, the results of the acute toxicity test suggest a beneficial effect of acanthocephalan infection for G. roeselii at polluted sites. A strong accumulation of pollutants in the parasite could serve as a sink for pesticide exposure of the host. Due to the lack of a co-evolutionary history between parasite and host and a lack of behavioral manipulation (unlike in co-evolved gammarids), the predation risk by fish remains the same, explaining high local prevalence. Thus, our study exemplifies how organismic interaction can favor the persistence of a species under chemical pollution.
Social Isolation, Healthy Habits, Inequality and Mental Health in the United States
Authors: Amate-Fortes Ignacio , Guarnido-Rueda Almudena , Martínez-Navarro Diego , Oliver-Márquez Francisco J. 
Published: March 2023

AbstractThe objective of this work is to deepen the analysis of the socioeconomic determinants of mental health, paying special attention to the impact of inequality, not only in income distribution but also in gender, racial, health and education inequality, social isolation, including new variables to measure loneliness, and healthy habits, on the mental health status. For this purpose, a cross-sectional model for a sample of 2735 counties in the United States is estimated using Ordinary Least Squares in its robust version to solve the detected heteroscedasticity problems. The results obtained show that inequality, social isolation and certain lifestyles, such as smoking or insomnia, are detrimental to mental health, while sexual activity prevents mental distress. On the other hand, poor counties suffer more cases of suicide, with food insecurity being the main problem for mental health. Finally, we found detrimental effects of pollution on mental health.
Modeling desirable futures at local scale by combining the nature futures framework and multi-objective optimization
Authors: Haga Chihiro , Maeda Marimi , Hotta Wataru , Matsui Takanori , Nakaoka Masahiro , Morimoto Junko , Shibata Hideaki , Hashimoto Shizuka , Saito Osamu , Okayasu Sana , Kim HyeJin , Peterson Garry 
Published: March 2023

AbstractEnvisioning positive scenarios that recognize the multiple values of nature is fundamental for designing transformative changes in local socio-ecological systems. This study developed a protocol with three specifications for operationalizing the Nature Futures Framework (NFF) in a landscape scenario analysis using a multi-objective optimization framework composed of: (1) exploring nature-positive futures, (2) seeking alternative pathways for targets satisfying visions of plural values, and (3) screening key direct drivers to achieve the targets. This research conducted a case study of a rural landscape in northeastern Japan. First, 110 strategies of landscape management options were simulated from 2015 to 2100 using a forest landscape model, LANDIS-II. The simulation developed a data frame of four integrated indicators of the NFF values for each year and strategy. Second, nature-positive strategies were screened using the common values. Pareto optimal strategies were then identified to obtain equally good solutions. Finally, the key response options to achieve good nature-positive futures were identified using decision tree analysis. Our protocol identified (1) multiple, but few nature-positive and Pareto optimal strategies that satisfied NFF visions, (2) nature-positive, but not Pareto optimal strategies, and (3) non-nature-positive strategies. In most Pareto optimal strategies, the maximized value perspectives changed over time. Our protocol also identified key response options to achieve three different NFF value perspectives in the case study area: (1) clear or selective cutting in forestry and (2) solar PV installation on abandoned pastureland in agriculture and energy sectors. We discussed the implication for local landscape management, localizing NFF narratives to develop future scenarios and modeling practice of NFF. The protocol does not depend on a specific model and indicator. Thus, our scalable protocol can be applied to scenarios and model practices in any region to support envisioning plausible, feasible, and positive futures, and designing future stakeholder collaboration.
Influence of Grain Size and Volume Fraction of η/δ Precipitates on the Dwell Fatigue Crack Propagation Rate and Creep Resistance of the Nickel-Base Superalloy ATI 718Plus
Authors: Kirchmayer A. , Pröbstle M. , Huenert D. , Neumeier S. , Göken M. 
Published: March 2023

AbstractRecently, it was found that the orientation of theη/δplates in the Ni-base superalloys ATI 718Plus has a huge impact on the fatigue crack propagation behavior (Huenertet al.in Superalloys pp.781–792, 2016). However, the targeted alignment ofη/δprecipitates in components with complex geometry can be challenging in certain applications. Therefore, the effect of other microstructural features of ATI 718Plus, which are easier to manipulate, is tested with respect to their fatigue crack propagation behavior and creep strength. The grain size, theγ′ precipitate size, as well as theγ′ andη/δvolume fraction are varied by applying different heat treatments. An increase in theη/δvolume fraction as well as theγ′ volume fraction and precipitate size enhanced the crack growth resistance, but worsened the creep properties. On the contrary, increasing the grain size leads to better creep properties and better fatigue crack growth resistance. The impact of the different microstructures investigated in this study on the mechanical properties is smaller compared to microstructures with strongly alignedη/δplates. These results enable to design the desired microstructures that meet the particular demands of the given application regarding crack propagation and creep resistance.
Influence of the Cooling Rate on Mechanical and Corrosion Properties of Ferritic Si–Mo Ductile Cast Iron
Authors: Palumbo Gaetano , Górny Marcin , Bitka Adam 
Published: March 2023

Abstract
In this study, the effect of the cooling rate controlled by different castings thickness ranging from 3 to 25 mm on the mechanical and corrosion behavior of Si–Mo ductile iron (DI) castings was investigated. SEM-EBSD investigations demonstrated that the nodule counts, nodularity, and ferrite phase increased while the ferritic grain size decreased with decreasing in the casting wall thickness; this in turn led to improvements in the tensile properties of the DI. The corrosion behavior of Si–Mo DI castings was investigated after different immersion times in a 3.5 wt pct NaCl solution via electrochemical experiments. The electrochemical results showed that the corrosion resistance of Si–Mo DI decreased in the following order: 3 > 5 > 13 > 25 mm. The results indicated that all of the tested DI samples exhibited galvanic corrosion between the nobler carbide and ferritic matrix phases. SEM analysis showed that the dissolution of the ferrite phase with the pearlite phase exposed and accumulated on the DI’s surface, which led to intense corrosion acceleration. The higher corrosion rates that were observed for those samples with higher casting wall thicknesses could be associated with the higher contents of pearlite/carbide.
Synthesis and characterization of a smart polymer-coated core–shell MnFe2O4@ organometallic framework for targeted drug delivery
Authors: Abdollahy Maryam , Peyman Hossein , Roshanfekr Hamideh , Idris Azeez Olayiwola , Azizi Shohreh , Sibali Linda Lunga 
Published: March 2023

AbstractScientists are currently working to develop more effective and less harmful methods of delivering drugs to tissue. One method is to use a special type of carrier to help the drug get to the right place in the body. In this study, an organometallic framework nanocarrier with the formula IRMOF-3 [Zn4O(NH2-BDC)3] was successfully prepared, containing magnetic nanoparticles of manganese ferrite (MnFe2O4) and the drug doxorubicin encapsulated in a pH- and temperature-sensitive smart polymer of poly-N-isopropylacrylamide. Doxorubicin, an anticancer drug, was loaded into the pores of a magnetic organometallic framework and modified with the smart polymer poly(N-isopropylacrylamide-co-AA), which has a lower critical solution temperature (LCST) of less than 38 °C. The synthesis of magnetic nanoparticles and magnetic organometallic frameworks encapsulated in smart polymer was investigated using various analytical techniques such as Fourier transform infrared spectrometer, thermal stability analysis, BET, and VSM. The particles in the synthesized nanocarrier are uniform in size, have high magnetic properties, and are thermally stable. The effective surface area is 7.26 m2/g, and the pore volume is 166.394 m. The drug carrier has the ability to load up to 78% of the drug into the solution. The highest drug release was observed when the pH was 5 and the temperature was higher than the LCST. 71% of cancer cells were destroyed by the drug carrier in the culture medium. This nanosystem, designed with more drug retention, reduced side effects and controlled release in different conditions, is suitable as a drug delivery system.
People with higher relationship satisfaction use more humor, valuing, and receptive listening to regulate their partners’ emotions
Authors: Walker Sarah A. , Pinkus Rebecca T. , Olderbak Sally , MacCann Carolyn 
Published: March 2023

AbstractThe emotional experiences you have with a romantic partner shape how satisfied you are in your relationship. Engaging in attempts to make a romantic partner feel better is linked with better relationship outcomes. However, it is not yet clear which specific processes people use to regulate their partners’ emotions, nor which processes are most strongly linked with relationship satisfaction. In the current study of 277 individuals (55% female), we tested the extent to which eight extrinsic emotion regulation processes (expressive suppression, downward social comparison, humor, distraction, direct action, reappraisal, receptive listening, and valuing) predict relationship satisfaction. Six of the eight processes showed significant positive correlations with relationship satisfaction, with the strongest associations for valuing (r = .43), humor (r = .33), and receptive listening (r = .27). Relative weights were significant only for valuing, humor, and receptive listening, suggesting that these are the most important predictors of relationship satisfaction. Results are discussed in terms of the distinction between intrinsic and extrinsic regulation processes and the potential importance of motives for regulation.
Are my parents psychopaths? How Mental health and self-esteem is impacted by perceived dark traits in parents
Authors: Coelho Gabriel Lins de Holanda , Monteiro Renan P. , Lannes Amanda , Blanche Jane , Antunes Natalia , Avelino Nayara , Rhaykemi Victória 
Published: March 2023

AbstractRelationships between parents and their descendants are necessary for healthy socio-emotional development. For a better understanding of these relationships, past studies found that personality traits significantly impact parenting constructs, such as attachment patterns, parental care, and relationship satisfaction, suggesting that the psychological aspects of parents can affect their descendants. In our research (N = 250), we asked participants to rate how they perceive their parents regarding their aversive personality traits (i.e., Dark Triad), parenting style characteristics, relationship satisfaction, and their own well-being and self-esteem. We then developed two mediational models (SEM), one for mothers and one for fathers. In these models, we assessed how the Dark Triad impacted mental health and self-esteem, mediated by authoritarian parenting style and relationship satisfaction. The models presented a good fit (e.g., CFI > 0.90). Psychopathic traits positively influenced an authoritarian parenting style for both parents, leading to worse relationship satisfaction and affecting their descendants’ mental health and self-esteem. Furthermore, we also observed the indirect effects of parental psychopathy on our outcomes, which were higher for mothers than fathers. Overall, our study provides the first assessment of how parents’ higher levels of dark traits can influence their descendants’ mental health and self-esteem.
Geographic range extension of hop cyst nematode, Heterodera humuli, from Tasmania to the Australian mainland
Authors: Jain Akshita , Huston Daniel C. , Wainer John , Hodda Mike , Hayes Oliver , Whittock Simon , Darling Elisabeth , Mann Ross , Edwards Jacqueline , Rodoni Brendan , Sawbridge Timothy 
Published: March 2023

AbstractHop cyst nematode, Heterodera humuli Filipjev, 1934 was found in soil samples collected from hop farms in Bushy Park, Tasmania and in Merriang, Victoria, Australia. Morphological and molecular characteristics were consistent with those described for this species in other parts of the world. Novel gene sequences of ITS rRNA, 28S rRNA and CO1 mtDNA generated from cysts were compared against sequences of H. humuli available on the NCBI GenBank database, demonstrating little to no genetic variation between Australian hop cyst nematode populations and those from other regions. This report provides the first molecular sequence data for H. humuli from Australia and reports a significant range extension of this cyst nematode from Tasmania to the Australian mainland.
Annealing effect on structural and optical properties of glad synthesized Gd2O3 nanorod
Authors: Meitei Ph. Nonglen , Singh Naorem Khelchand 
Published: March 2023

AbstractGadolinium oxide nanorod (Gd2O3 NR) was fabricated on an n-type silicon substrate by catalyst-free glancing angle deposition (GLAD) technique. The as-grown sample was annealed at 500 °C to investigate the impact of annealing on structure and optical properties. XRD analysis reveals an improvement in the crystal structure after annealing. Field emission scanning electron microscope (FE-SEM) and energy dispersive X-ray (EDX) confirm the successful growth of vertically aligned Gd2O3 NR with the presence of Gd, O, and Si. Transmission electron microscope (TEM) showed the crystalline nature of the grown Gd2O3 NR. Finally, UV–vis spectroscopy was performed to study the optical properties. A significant enhancement in the photon absorption (200–300 nm) was observed, which can be attributed to increased grain size, improved crystallinity, and large generation of electron–hole pairs. In addition, the Tauc plot showed a decrease in the bandgap from 5.05 eV to 4.98 eV after annealing at 500 °C.
Indifference to Anti-Humean Chances
Authors: Gallow J. Dmitri 
Published: March 2023

AbstractAn indifference principle says that your credences should be distributed uniformly over each of the possibilities you recognise. A chance deference principle says that your credences should be aligned with the chances. My thesis is that if we are anti-Humeans about chance, then these two principles are incompatible. Anti-Humeans think that it is possible for the actual frequencies to depart from the chances. As long as you recognise possibilities like this, you cannot both spread your credences evenly and defer to the chances. I discuss some weaker forms of indifference which will allow anti-Humeans to defer to the chances.
Guided antipsychotic reduction to reach minimum effective dose (GARMED) in patients with remitted psychosis: a 2-year randomized controlled trial with a naturalistic cohort
Authors: Liu Chen-Chung , Hsieh Ming H. , Chien Yi-Ling , Liu Chih-Min , Lin Yi-Ting , Hwang Tzung-Jeng , Hwu Hai-Gwo 
Published: March 2023

AbstractBackgroundPatients with remitted psychosis face a dilemma between the wish to discontinue antipsychotics and the risk of relapse. We test if an operationalized guided-dose-reduction algorithm can help reach a lower effective dose without increased risks of relapse.MethodsA 2-year open-label randomized prospective comparative cohort trial from Aug 2017 to Sep 2022. Patients with a history of schizophrenia-related psychotic disorders under stable medications and symptoms were eligible, randomized 2:1 into guided dose reduction group (GDR) v. maintenance treatment group (MT1), together with a group of naturalistic maintenance controls (MT2). We observed if the relapse rates would be different between 3 groups, to what extent the dose could be reduced, and if GDR patients could have improved functioning and quality of life.ResultsA total of 96 patients, comprised 51, 24, and 21 patients in GDR, MT1, and MT2 groups, respectively. During follow-up, 14 patients (14.6%) relapsed, including 6, 4, and 4 from GDR, MT1, and MT2, statistically no difference between groups. In total, 74.5% of GDR patients could stay well under a lower dose, including 18 patients (35.3%) conducting 4 consecutive dose-tapering and staying well after reducing 58.5% of their baseline dose. The GDR group exhibited improved clinical outcomes and endorsed better quality of life.ConclusionsGDR is a feasible approach as the majority of patients had a chance to taper antipsychotics to certain extents. Still, 25.5% of GDR patients could not successfully decrease any dose, including 11.8% experienced relapse, a risk comparable to their maintenance counterparts.
Under suspicion: library music and the Musicians’ Union in Britain, 1960–1978
Authors: Roy Elodie A. 
Published: March 2023

AbstractDrawing primarily from unpublished archival data, this article reconstructs the Musicians’ Union long embargo on library recording in Britain (1965–1978), retracing the immediate as well as long-lasting implications of the ban for the shaping of library music practices and discourses. The article demonstrates how crucial relations with the Union were in shaping the nascent library music industry as well as the working lives of the many individuals and groups involved in it, including London-based session musicians and music publishers. More theoretically, the article argues for a horizontal, ecological approach to library music culture, acknowledging its many intermediaries and prompting us to consider (musical) history in its unfinishedness, heterogeneity and ambiguity. The methodological challenges of researching ephemeral or ‘secondary’ music are also highlighted.