bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nf-κβ Inhibitor – Dehydroxymethylepoxyquinomicin Reduces Iron Iso-Maltoside Toxicity Towards Peritoneal Mesothelial Cells
Authors: Breborowicz Andrzej , Umezawa Kazuo 
Published: June 2023

Background. Intravenous iron therapy is used in treatment of anemia in uremic pa-tients. In patients treated with peritoneal dialysis iv. infused iron diffuses into the peritoneal cavity and may cause injury to the mesothelial cell.
Methods. We studied effect of Iron Isomaltoside (IIS) in presence of NF-κβ inhibitor dehydroxymethyepoxyquinmicin (DHMEQ) on function of the peritoneal mesothelial cells. Experiments were performed on human peritoneal mesothelial cells in in vitro culture ex-posed to IIS 15 ug/dL ± DHMEQ 1 ug/mL. Intracellular oxidative stress, secretory activity and collagen synthesis in the cells were studied.
Results. IIS induced oxidative stress in the mesothelial cells and that effect was weaker in presence of DHMEQ (-52%,p&lt;0.001). In cells exposed to IIS increased expression of genes for IL6 (+74%,p&lt;0.001), PAI-1 (+43%, p&lt;0.01) and TGFβ (+53%,p&lt;0.001) was observed and reduced for tPA (-36%,p&lt;0.01). In presence of IIS increased secretion of IL6 (+56%, p&lt;0.001), TGFβ (+49%,p&lt;0.001) and PAI-1 (+51%, p&lt;0.001) was observed whereas secretion of tPA was reduced (-25%, p0.001). DHMEQ reduced changes in genes and secre-tory activity caused by IIS. In presence of IIS synthesis of collagen in mesothelial cells was increased (+45%,p&lt;0.001) and that effect was weaker (-25% vs. IIS, p&lt;0001) when simulta-neously DHMEQ was used.
Discussion. IIS induces proinflammatory changes in mesothelial cells, deteriorates their fibrinolytic activity and stimulates synthesis of collagen. All these effects are reduced when simultaneously NF-κβ inhibitor – DHMEQ is used.
Incidence and prevalence of Neurofibromatosis type 1 and 2: a systematic review and meta-analysis
Authors: Lee Tin-Suet Joan , Chopra Meera , Kim Raymond H , Parkin Patricia C. , Barnett Carolina 
Published: June 2023

Abstract
Objective
To obtain updated estimates of the incidence and prevalence of neurofibromatosis type 1 (NF1) and type 2 (NF2).
Study design:
We conducted a systematic search of NF1 and NF2 incidence or prevalence studies, in OVID Medline, OVID Embase, Web of Science, and Cinahl. Studies were appraised with the Joanna Briggs Institute Prevalence Critical Appraisal tool. Pooled incidence and prevalence rates were estimated through random-effects meta-analysis.
Results
From 1,939 abstracts, 20 studies were fully appraised and 12 were included in the final review. Pooled NF1 prevalence was 1 in 3,190 (95%CI: 1 in 1,140-1 in 4,755). This was higher in studies that screened for NF1, compared to identification of NF1 through medical records (1 in 2,021 and 1 in 4,403, respectively). NF1 pooled birth incidence was 1 in 2,662 (95%CI: 1 in 1,968-1 in 3,601). There were only 2 studies on NF2 prevalence, so data were not pooled. Pooled NF2 birth incidence was 1.08 per 50,000 births (95%CI: 1 in 32,829-1 in 65,019).
Conclusion
The prevalence of NF1 is higher than previously reported, with higher rates seen in screening studies which suggests that the disease may be under recognized. More studies are needed regarding the prevalence of NF2.
Single Relaxation Time and Multiple Revised Matrix Lattice Boltzmann Simulations of Forced Isotropic Turbulence
Authors: Kareem Waleed Abdel 
Published: June 2023

Abstract
The single relaxation time (SRT) and the revised matrix (RM) lattice Boltzmann models are investigated for simulations of three dimensional forced isotropic turbulence with resolutions of 1283, 2563, and 5123, respectively. It is found that the density ρ is almost unity at all lattice timesteps for the MRT case, while disturbance about unity is observed for the SRT case. Also, thinner vortex structures are observed for the MRT results in comparison with the SRT cases specially for higher resolutions. The velocity distributions for the MRT results are found similar to the results of the Navier-Stoks standard solutions. One of the disadvantages of the MRT case is the simulation time which is found more than twice the SRT simulation time, where about 24 seconds are needed for each lattice timestep in the 2563 case in comparison to 12:6 seconds for the SRT model using the same hardware resources. In the case of 5123 grid points about 648 seconds are consumed for one lattice timestep which is found as more than three times the SRT case which needs 198 seconds. The initial velocity field is chosen as u(x; 0) = 0 and the force is injected at low wave-numbers with a fixed forcing amplitude of 10-4 for all cases. The single relaxation time is set to τ = 0.503 in all SRT simulations. Results show that the obtained turbulent velocity fields yield universal characteristics as found in previous Navier-Stoks numerical studies of the same problem.
Effect of Once vs. Twice Intracoronary Injection of Allogeneic-Derived Mesenchymal Stromal Cells after Acute Myocardial Infarction: BOOSTER-TAHA7 Randomized Clinical Trial
Authors: Attar Armin , Kouhanjani Mohsen Farjoud , Hessami Kamran , Vosough Massoud , Kojuri Javad , Ramzi Mani , Hosseini Seyed Ali , Faghih Marjan , Monabati Ahmad 
Published: June 2023

Abstract
Background: Mesenchymal stromal cell (MSC) transplantation can improve the left ventricular ejection fraction (LVEF) after an acute myocardial infarction (AMI). Transplanted MSCs apparently exert a paracrine effect, which might be augmented if repeated doses are administered. This study aimed to compare the effects of single vs.double transplantation of Wharton’s jelly MSCs (WJ-MSCs) on LVEF post-AMI.
Methods: We conducted a single-blind, randomized, multicenter trial. After 3-7 days of an AMI treated successfully by primary PCI, 70 patients younger than 65 with LVEF <40% on baseline echocardiography were randomized to receive conventional care, a single intracoronary infusion of WJ-MSCs, or a repeated infusion ten days later. The primary endpoint was the six-month LVEF improvement as per cardiac magnetic resonance (CMR) imaging.
Results: The mean baseline EF measured by CMR was similar (~40%) in all three groups. By the end of the trial, while all patients experienced a rise in EF, the most significant change was seen in the repeated intervention group. Compared to the control group (n=25), single MSC transplantation (n=20) improved the EF by 4.54 ± 2%, and repeated intervention (n=20) did so by 7.45 ± 2% when measured by CMR imaging (P<0.001); when evaluated by echocardiography, these values were 6.71 ± 2.4 and 10.71 ± 2.5%, respectively (P<0.001).
Conclusions: Intracoronary transplantation of WJ-MSCs 3-7 days after AMI in selected patients significantly improves LVEF, with the infusion of a booster dose ten days later augmenting this effect.
Trial registration: Trial registration: Iranian Registry of Clinical Trials, IRCT20201116049408N1. Registered 20 Nov. 2020 - Retrospectively registered, https://en.irct.ir/trial/52357
Plantar Pressure Analysis in Children with Cerebral Palsy While Wearing Orthoses - a Descriptive Study
Authors: Raposo Maria Raquel , Ricardo Diogo , Veloso Antonio Prieto , João Filipa 
Published: June 2023

Abstract
Background Cerebral Palsy (CP) is the most common cause of motor disability in children, often leading to different musculoskeletal abnormalities, including foot deformities. Ankle-foot orthoses are commonly prescribed to minimize abnormal foot posture and to minimize the impact of spasticity on daily function. Dynamic pedobarography may provide new data to better assess the changes in plantar pressure distribution throughout the stance phase of gait in children with Cerebral Palsy.Methods Nine children with CP walked wearing plantar pressure insoles inside their orthoses and regular footwear. Mean values and standard deviation were calculated for each variable in a total and a segmented foot analysis. Clusters based on clinical distribution of spasticity, gait pattern and type of orthoses were created to allow for further analysis.Results Overall data was consistent across all participants and clusters. The use of AFO did not significantly impact any of the mean values for the variables in study, when referencing to the means of the same variables in children with CP walking in regular footwear. The cluster analysis revealed increased pedobarography values in Unilateral CP, Apparent Equinus gait pattern and Dynamic AFO sub-groups. In the segmented foot analysis, all variables increased from heel to the fore foot.Conclusions The use of AFO in children with CP produce positive changes in plantar pressure measurements, approximating them to the reference percentiles of typically developing children.
A novel prognostic model to predict mortality in patients with acute-chronic liver failure in intensive care unit
Authors: Lin Shih-Hua , Chen Wei-Ting , Tsai Ming-Hung , Liu Li-Tong , Kuo Wei-Liang , Lin Yan-Ting , Wang Sheng-Fu , Chen Bo-Huan , Lee Cheng-Han , Huang Chien-Hao , Chien Rong-Nan 
Published: June 2023

Abstract

Background Acute on chronic liver failure (ACLF) implies high short-term mortality rates and usually requires intensive care unit (ICU) admission. Proper prognosing these patients is crucial for early referral for liver transplantation. The superiority of CLIF-C ACLF score in Asian patients with ACLF admitted to an ICU remains inconclusive when compared to other scoring systems. The purpose of the study is (i) to compare the predictive performance of original MELD, MELD-Lactate, CLIF-C ACLF, CLIF-C ACLF-Lactate, and APACHE-II scores for short-term mortality assessment. (ii) to build and validate a novel scoring system and to compare its predictive performance to that of the original five scores. Methods 265 consecutive cirrhotic patients with ACLF who were admitted to our ICU were enrolled. The prognostic values for mortality were assessed by ROC analysis. A novel model was developed and internally validated using 5-fold cross-validation. Results Alcohol abuse was identified as the primary etiology of cirrhosis. The AUROC of the five prognostic scores in predicting one-month mortality prediction were not significantly superior to each other in predicting one-month and three-month mortality. The newly developed prognostic model, incorporating age, A-a gradient, BUN, total bilirubin level, INR, and HE grades, exhibited significantly improved performance in predicting one-month and three-month mortality with AUROC of 0.863 and 0.829, respectively, as compared to the original five prognostic scores. Conclusions The novel ACLF model is superior to the original five scores in predicting short-term mortality for ACLF patients admitted to an ICU. Further rigorous validation is required.
Concept analysis of a distributed thrust system, a novel induction propulsion method using high energy pulse solenoids in satellite swarms for reusable interorbital freight transport.
Authors: Wegener Morgan J. 
Published: June 2023

Abstract
To date only single vehicle thrust designs have been considered for propulsion in space, however there is no limitation preventing multivehicle distributed thrust application designs. By considering the regularity of planetary orbits and distance between orbital paths, a location in space can be targeted for next orbit arrival of a shipping container propelled on an intercepting vector that is a result of induction propulsion vector combination. This concept is achieved with Nb3Sn high energy pulse solenoids that enable a square pyramidal swarm of satellites to decompose the intercepting orbital transfer vector and propel a 20 tonne steel shipping container towards a destination swarm. This paper is a thought experiment with first pass mechanical analysis that establishes a validity algorithm then concludes that the proposed yoked solenoid design is fit for purpose and the concept is theoretically functional. The launch vector is perpendicular to the swarm’s orbital path thus force application, reaction and orbital maintenance strategies are investigated. A yoke rod’s enhancement of a superconductive solenoid’s force output and the reaction force distribution model are noted as key variances that must be investigated in further research with numerical modelling tools before the proposed design can be considered fully functional and viable for experimental testing. This design is a dedicated freight transport solution to high mass, high volume cargo required by future astronauts, such as construction machinery and materials.
A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes.
Authors: Harris Erica , Roy Vincent , Montagne Martin , Rose Ailsa , Livesey Helen , Hobson Emma , Warren Daniel , Long Vernon , Sheridan Eamonn , Reijnders Margot , Sansbury Francis , Willemsen Marjolein , Pfundt Rolph , Brunner Han , Carr Ian , Firth Helen , Lavigne Pierre , Poulter James 
Published: June 2023

Abstract
Cyclin D2 (CCND2) stabilisation underpins a range of macrocephaly-associated disorders through mutation of CCND2, or activating mutations in upstream genes encoding PI3K-AKT pathway components. Here we describe three individuals with overlapping macrocephaly-associated phenotypes who carry the same recurrent de novo p.Arg60Gln variant in Myc-associated factor X (MAX). The mutation, located in the b-HLH-LZ domain, causes increased levels of CCND2 through increased transcription, and not stabilisation of CCND2. We show the purified b-HLH-LZ domain of MAXR60Q (Max*R60Q) binds its target E-Box sequence with a lower apparent affinity. This leads to a more efficient heterodimerization with c-Myc resulting in an increase in transcriptional activity of c-Myc in patients carrying this mutation. The recent development of Omomyc-CPP, a cell penetrating b-HLH-LZ domain c-Myc inhibitor, provides a possible therapeutic option for MAXR60Q patients, and others carrying similar germline mutations resulting in dysregulated transcriptional c-Myc activity.
Emergence of flat bands via orbital-selective electron correlations in Mn-based kagome metal
Authors: Samanta Subhasis , Park Hwiwoo , Jeon Sungmin , Lee C. H. , Cui Hengbo , Hwang Jungseek , Choi Kwang-Yong , Kim Heung-Sik 
Published: June 2023

Abstract

Kagome lattice has been actively studied for the possible realization of frustration-induced two-dimensional flat bands and a number of correlation-induced phases. Currently, the search for kagome systems with a nearly dispersionless flat band close to the Fermi level is ongoing. Here, by combining theoretical and experimental tools, we present Sc3Mn3Al7Si5 as a novel realization of correlation-induced almost-flat bands in the kagome lattice in the vicinity of the Fermi level. Our magnetic susceptibility, 27Al nuclear magnetic resonance, transport, and optical conductivity measurements provide signatures of a correlated metallic phase with tantalizing ferromagnetic instability. Our dynamical mean-field calculations suggest that such ferromagnetic instability observed originates from the formation of nearly flat dispersions close to the Fermi level, where electron correlations induce strong orbital-selective renormalization and manifestation of the kagome-frustrated bands. In addition, a significant negative magnetoresistance signal is observed, which can be attributed to the suppression of flat-band-induced ferromagnetic fluctuation, which further supports the formation of flat bands in this compound. These findings broaden a new prospect to harness correlated topological phases via multiorbital correlations in 3d-based kagome systems.
Nursing Process related to nursing focus "Airway Clearance": A Scoping Review “Nursing Process related to nursing focus "Airway Clearance": A Scoping Review”
Authors: Gaspar Luis Jorge Rodrigues , Reis Neuza Cristina Moura , Sousa Paula Cristina Moreira Mesquita , Silva Abel Avelino Paiva e , Cardoso Alexandrina Maria Ramos , Brito Maria Alice Correia , Morais Ernesto Jorge de Almeida , Bastos Fernanda Santos , Oliveira Manuel Fernando dos Santos , Sousa Inês Maria da Cruz Sousa , Campos Maria Joana Alves , Gonçalves Paulo José Parente , Pereira Filipe Miguel Soares , Machado Natália de Jesus Barbosa 
Published: June 2023

Abstract

Background
Each year, more than a billion people suffer from respiratory diseases leading to about 4 million deaths worldwide. Airway Clearance impairment is deeply related to these diseases causing a significant impact on self-care and quality of life. Therefore, it is essential to identify clinical data, nursing diagnoses and nursing interventions, providing a solid basis for clinical reasoning and integrating the best scientific evidence to enhance nursing care. This scoping review aims to map the existing evidence on clinical data, nursing diagnoses and nursing interventions addressing nursing focus “Airway Clearance”.
Methods
A scoping review was performed according to Joanna Briggs Institute framework. We searched MEDLINE, CINAHL Complete, Scopus, Web of Science, and PEDro databases for published English, Portuguese, and Spanish literature between 1975 and 2021. It included all studies on airway clearance in adult patients in all contexts of nursing care. Quantitative, qualitative, and mixed-methods studies, as well as systematic reviews, were included. The PRISMA-ScR checklist was used.
Results
In total 1355 studies were identified. After removing duplicates, 104 matched the inclusion criteria and were included in the review. The findings of this review showed two areas of nursing attention: one related to signs and symptoms management and the other related to health/illness transition. The data that lead to nursing diagnoses can be divided into cognitive and clinical data. The nursing diagnoses were mostly related to secretions retention, excessive mucus production and airway obstruction. The most commonly identified nursing interventions were the educational interventions assembled into pre-design education programs rather than patient-tailored programs.
Conclusions
The findings of this review can add substantial value for systematising the nursing process related to nursing focus “Airway Clearance”. Reaching a consensus seems highly relevant, as it could improve nursing decision-making, nursing care quality and produce more reliable nursing outcomes.
Effective Implementation of Water Supply Using EPANET Software
Authors: Srivas Rajat , Kumar Hareesh , Kumar Nishank , Dubey Ravi , Gupta Utkarsh 
Published: June 2023

Abstract
In College United Institute Of Technology, Naini, Prayagraj which is the area of case study, the system of water supply assumed in this project is tree or dead end system network for distribution of water in College. The study of our project is related to the effective implementation of water supply using EPANET software in College United Institute Of Technology which provide water distribution network for institutional water demand. The main problem which is try to solve by this project is to know the pressure intensity of water, diameter of pipe, length of pipe , before the installation of pipe on site or land. This project solves all this problems because EPANET software tells the pressure intensity of water, diameter of pipe, length of pipe etc. of any pipe network. The procedure which we followed during this project is to find elevation of ground through which pipes are passed then make a suitable pipe network on EPANET software add nodes, diameter, length of pipes and then do analysis by run it. This result or analysis gives the effective distribution system in United Institute Of Technology College with effective pressure, velocity, and discharge.
Estimating the contribution of mobile sources to ambient particulate matter: an indirect methodology
Authors: Sole Micaela Belén Del , Ferraro Santiago Aguilar , Giuliani Daniela Silvana , Balbi Karina Beatriz , Lerner Jorge Esteban Colman , Porta Atilio Andrés , Sanchez Erica Yanina 
Published: June 2023

Abstract
Several countries have mixed industrial-residential zones, favoured by social dynamics and the absence of land-use planning policies. Identifying the contributions of different emission sources to ambient pollution levels helps to guide air quality management efforts. Although more importance is given to stationary sources, recent studies have shown the strong contribution of mobile sources, the control of which is more complex. In this context, it is proposed to develop a simple and indirect methodology to identify the emission contributions of mobile sources to ambient particulate matter in industrial-residential areas, based on existing monitoring networks designed for stationary sources and inventories of these sources and the AERMOD View® modelling system. Mobile sources are usually neglected in industrial areas, but here they are presented as a relevant source to the contributions of ambient levels of particulate matter below 10 micrometres (PM10) due to the expansion of residential areas over industrial areas. The contribution from stationary sources at each of the six receptor sites studied varies between 9.6% and 32.2%, with the exception of one of the receptors, which reaches 99.3% due to its proximity to the main stationary source of emissions. When comparing the maximum controlled values at the receptors with the guideline levels suggested by the World Health Organization (WHO), the latter are exceeded for both exposure periods. However, none of the values estimated with AERMOD View at the receptors exceed the WHO guideline levels. This shows that stationary sources are not the most relevant.
Iso-severity flood hazard patterns in diverse relief and climatic regions to support flood management
Authors: Mostafazadeh Raoof , Khiavi Ali Nasiri , Khiavi Hossein Talebi 
Published: June 2023

Abstract
Floods are one of the most devastating natural events that threaten social and economic conditions more than any other natural disaster. Therefore, the aim of this study was to map the Iso-severity flood patterns and determining the seasonality of flood events over different return periods in in Ardabil province, Iran with diverse relief and climatic regions. Thus, the data of 32 River Gauge Stations (RGS) were used in the spatiotemporal analysis in a 40-year recorded period. EasyFit software was used to determine the most appropriate statistical distribution for the discharge data at 2-, 5-, 10-, 25-, 50- and 100-year return periods. Then, the frequency of monthly and seasonal flood events was quantified in each RGS. Then, the significant trend of flood frequency in each RGS was tested, and the seasonality of flood events was explored. According to the results, it can be said that in the studied RGS, about 63.63% of the floods are occurred in April. On the other hand, the seasonality of flood events showed that the maximum number and percentage of flood events are assigned to spring season over different return periods. As in some stations such as Yamchi, Nouran, Naneh-Karan, Mashiran, Amouqin, Doroud and Pole- Almas, almost 100% of the floods are related to spring and this shows that the floods in Ardabil province are spring floods. Iso-severity flood mapping in different return periods showed that the frequency of floods was higher than the central and northern regions in the southern and highlands of the study area. It is necessary for the southern and Iso-severity flood areas of the province, while conducting the necessary studies, proper planning should be considered with the focus on Integrated Watershed Management (IWM) in order to reduce the flood occurrence in the future and minimize its human and economic losses.