bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uluslararası ve Ulusal Çalışmaların Hemşirelik Eğitimine Yansımaları
Authors: KÜÇÜK YÜCEYURT Nil , AKÇİN ŞENYUVA Emine , KAYA Prof.dr.hülya 
Published: May 2023

Hızla değişen küresel dinamikler gibi toplumsal yapıda, sağlık bakım hizmetlerinde, eğitimde ve hemşirelik eğitiminde değişme ve
gelişmeler yaşanmaktadır. Yaşanan bu değişme ve gelişmelere uyum sağlamak ve gelişmiş, nitelikli hemşirelik bakımı sunmak için hemşirelik
eğitiminin de dinamik ve nitelikli olması gerekmektedir. Bu bağlamda hemşirelik eğitimini iyileştirmek, güncellemek ve güçlendirmek
amacıyla hemşirelik ve hemşirelik eğitimini konu alan kurum ve kuruluşların çalışmaları ile küresel ve bölgesel olarak yürütülen ortak
çalışmalar mevcuttur. Bu kurum, kuruluş ve ortak çalışmaların hemşirelik eğitimine olan etkilerinin farkında olmak ve hemşireler olarak
bu süreçlerde yer almak hemşireliğin gelişimi ve iyileştirilmesinde hemşirenin rolü ve sorumluluğudur.
Hemşirelik ve hemşirelik eğitimi alanında yürütülen çalışmaların hemşirelik eğitimine yansımalarının farkında olmak amacıyla hazırlanan
derlemede, hemşirelik ve hemşirelik eğitiminin geçmişini ve bugününü anlayarak geleceğine yön veren/etkileyen kurum ve kuruluşlar,
bu kurum ve kuruluşların yayınladıkları deklarasyonlar, bildirgeler, toplantı raporları, yasa ve yönetmelikler vb incelenerek hemşirelik
eğitimine etkileri ele alınmıştır. Bu bağlamda hemşireler, hemşire eğitimciler, politikacılar ve hemşirelik eğitimine etki eden tüm paydaşlar
açısından var olan etkilerin derlenmesi ve gelecek çalışmalarına fikir vermesi yönünde özet niteliğinde bilgiler sunulmaktadır.
Determination of Antibiotic Prescription Pattern in Private Healthcare Facilities in Port Harcourt Metropolis, Rivers State, Nigeria
Authors: Awopeju A. T. O. , Chijioke-Nwauche I. 
Published: May 2023

Background: The consequences of antimicrobial resistance are severe, as mortality and morbidity rates continue to increase. The extensive use of antibiotics contributes significantly to the development and spread of antimicrobial resistance. It is crucial to have knowledge supported by data to improve antimicrobial stewardship and address the growing problem of antimicrobial resistance globally and locally. Thus, an evaluation was conducted to assess the prescription practices of doctors working in private medical facilities in Port Harcourt, Rivers state, Nigeria.
Methods: A cross-sectional survey was carried out using a structured questionnaire to collect information on medical training and antibiotic prescription practices among 102 medical doctors. Data was analyzed at a 95% confidence interval using the SPSS v25 software and a p-value less than 0.05 was considered significant.
Results: The respondents' demographics indicated that 67.6% were male, while 32.4% were female practitioners. The majority, about 60.8%, had MBBS only, while 21.6% had a postgraduate medical fellowship and 17.6% had postgraduate degrees (PGD/MSc/PhD). The data revealed that 35.3% of the respondents had practiced for at least 15 years, while 33.3% had practiced for 1-5 years and 23.5% for 6-10 years. Cephalosporins were commonly prescribed by 43.1% of the respondents, with cefuroxime being the most frequently prescribed. Amoxicillin was prescribed by 20.6% of the respondents, while only 2.9% of them indicated prescribing Penicillins V or G. Laboratory investigations were the basis for prescribing antibiotics in 30.4%, while 69.6% prescribed on an empirical basis. The cross-tabulation of basis of prescriptions with qualifications showed that persons with postgraduate medical fellowship (86.4%) mostly prescribed based on clinical judgment, while individuals with MBBS only least commonly prescribed by clinical judgment. The prescription by empirical assessment was also mostly common among individuals with 6-10 years of practice experience (75%). However, no statistically significant association was found between the basis of prescriptions and academic qualifications or years of practice.
Conclusion: The study's results revealed that doctors in private medical facilities in Port Harcourt have a strong inclination towards prescribing cephalosporins, particularly on empirical grounds rather than laboratory investigations. It is highly recommended to take immediate measures to promote the implementation of antimicrobial stewardship principles to address the local rise in antimicrobial resistance.
A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells
Authors: Hinton Antentor , Katti Prasanna , Christensen Trace A. , Mungai Margaret , Shao Jianqiang , Zhang Liang , Trushin Sergey , Alghanem Ahmad , Jaspersen Adam , Geroux Rachel E. , Neikirk Kit , Biete Michelle , Lopez Edgar Garza , Shao Bryanna , Vue Zer , Vang Larry , Beasley Heather K. , Marshall Andrea G. , Stephens Dominique , Damo Steven , Ponce Jessica , Bleck Christopher K. E. , Hicsasmaz Innes , Murray Sandra A. , Edmonds Ranthony A. C. , Dajles Andres , Koo Young Do , Bacevac Serif , Salisbury Jeffrey L. , Pereira Renata O. , Glancy Brian , Trushina Eugenia , Abel E. Dale 
Published: May 2023

AbstractMitochondria respond to metabolic demands of the cell and to incremental damage, in part, through dynamic structural changes that include fission (fragmentation), fusion (merging of distinct mitochondria), autophagic degradation (mitophagy), and biogenic interactions with the endoplasmic reticulum (ER). High resolution study of mitochondrial structural and functional relationships requires rapid preservation of specimens to reduce technical artifacts coupled with quantitative assessment of mitochondrial architecture. A practical approach for assessing mitochondrial fine structure using two dimensional and three dimensional high‐resolution electron microscopy is presented, and a systematic approach to measure mitochondrial architecture, including volume, length, hyperbranching, cristae morphology, and the number and extent of interaction with the ER is described. These methods are used to assess mitochondrial architecture in cells and tissue with high energy demand, including skeletal muscle cells, mouse brain tissue, and Drosophila muscles. The accuracy of assessment is validated in cells and tissue with deletion of genes involved in mitochondrial dynamics.
Silicate Nanoplatelets Promotes Neuronal Differentiation of Neural Stem Cells and Restoration of Spinal Cord Injury
Authors: Wang Yifan , Zhao Tengfei , Jiao Yiren , Huang Hanxu , Zhang Yongxiang , Fang Ao , Wang Xuhua , Zhou Yanling , Gu Haochen , Wu Qionghua , Chang Jiang , Li Fangcai , Xu Kan 
Published: May 2023

AbstractNeural stem cell (NSC) transplantation has been suggested as a promising therapeutic strategy to replace lost neurons after spinal cord injury (SCI). However, the low survival rate and neuronal differentiation efficiency of implanted NSCs within the lesion cavity limit the application. Furthermore, it is difficult for transplanted cells to form connections with host cells. Thus, effective and feasible methods to enhance the efficacy of cell transplantation are needed. In this study, the effect of Laponite nanoplatelets, a type of silicate nanoplatelets, on stem cell therapy is explored. Laponite nanoplatelets can induce the neuronal differentiation of NSCs in vitro within five days, and RNA sequencing and protein expression analysis demonstrated that the NF‐κB pathway is involved in this process. Moreover, histological results revealed that Laponite nanoplatelets can increase the survival rate of transplanted NSCs and promote NSCs to differentiate into mature neurons. Finally, the formation of connections between transplanted cells and host cells is confirmed by axon tracing. Hence, Laponite nanoplatelets, which drove neuronal differentiation and the maturation of NSCs both in vitro and in vivo, can be considered a convenient and practical biomaterial to promote repair of the injured spinal cord by enhancing the efficacy of NSC transplantation.
In Vitro 3D Spheroid Model Preserves Tumor Microenvironment of Hot and Cold Breast Cancer Subtypes
Authors: Dhandapani Hemavathi , Siddiqui Armaan , Karadkar Shivam , Tayalia Prakriti 
Published: May 2023

AbstractDynamic interaction of cancer, immune, and stromal cells with extracellular matrix components modulates and resists the response of standard care therapies. To mimic this, an in vitro 3D spheroid model is designed using liquid overlay method to simulate hot (MDA‐MB‐231) and cold (MCF‐7) breast tumor microenvironment (TME). This study shows increased mesenchymal phenotype, stemness, and suppressive microenvironment in MDA‐MB‐231‐spheroids upon exposure to doxorubicin. Intriguingly, the presence of human dermal fibroblasts enhances cancer‐associated fibroblast phenotype in MDA‐MB‐231‐spheroids through increased expression of CXCL12 and FSP‐1, leading to higher infiltration of immune cells (THP‐1 monocytes). However, a suppressive TME is observed in both subtypes, as seen by upregulation of M2‐macrophage‐specific CD68 and CD206 markers. Specifically, increased PDL‐1 expressing tumor‐associated macrophages along with FoxP3 expressing T regulatory cells are found in MDA‐MB‐231‐spheroids when cultured with peripheral blood mononuclear cells. Further, it is found that the addition of 1‐methyl‐tryptophan, a potent indoleamine‐2,3‐dioxygenase‐1 inhibitor, subsides the suppressive phenotype by decreasing the M2 polarization via downregulation of tryptophan metabolism and IL10 expression, particularly in MCF‐7 triculture spheroids. Thus, the in vitro 3D spheroid model of TME can be utilized in therapeutics to validate immunomodulatory drugs for various breast cancer subtypes.
A Multifunction Hydrogel‐Coating Engineered Implant for Rescuing Biofilm Infection and Boosting Osseointegration by Macrophage‐Related Immunomodulation
Authors: Ding Yao , Liu Genhua , Liu Shaopeng , Li Xuan , Xu Kun , Liu Peng , Cai Kaiyong 
Published: May 2023

AbstractInnovative methodologies combined with scavenging reactive oxygen species (ROS), alleviating oxidative stress damage and promoting macrophage polarization to M2 phenotype may be ideal for remodeling implant‐infected bone tissue. Herein, a functionalization strategy for doping Tannic acid‐d‐tyrosine nanoparticles with photothermal profile into the hydrogel coating composed of konjac gum and gelatin on the surface of titanium (Ti) substrate is accurately constructed. The prepared hydrogel coating exhibits excellent properties of eliminating biofilm and killing planktonic bacteria, which is based on increasing susceptibility to bacteria by the photothermal effect, biofilm‐dissipation effect of D‐tyrosine, as well as the bactericidal effect of tannic acid. In addition, the modified Ti substrate has effectively alleviated proinflammatory responses by scavenging intracellular excessive ROS and guiding macrophages polarization toward M2. More interesting, conditioned medium from macrophage indicates that paracrine is conducive to osteogenic proliferation and differentiation of mesenchymal stem cells. Results from rat model of femur infection in vivo demonstrate that the modified Ti implant significantly eliminates the residual bacteria, relieves inflammation, mediates macrophage polarization, and accelerates osseointegration. Altogether, this study exhibits a new perspective for the development of advanced functional implant with great application potential in bone tissue regeneration and repair.
Low‐Power and Field‐Free Perpendicular Magnetic Memory Driven by Topological Insulators
Authors: Cui Baoshan , Chen Aitian , Zhang Xu , Fang Bin , Zeng Zhaozhuo , Zhang Peng , Zhang Jing , He Wenqing , Yu Guoqiang , Yan Peng , Han Xiufeng , Wang Kang L. , Zhang Xixiang , Wu Hao 
Published: May 2023

AbstractGiant spin–orbit torque (SOT) from topological insulators (TIs) has great potential for low‐power SOT‐driven magnetic random‐access memory (SOT‐MRAM). In this work, a functional 3‐terminal SOT‐MRAM device is demonstrated by integrating the TI [(BiSb)2Te3] with perpendicular magnetic tunnel junctions (pMTJs), where the tunneling magnetoresistance is employed for the effective reading method. An ultralow switching current density of 1.5 × 105 A cm−2 is achieved in the TI‐pMTJ device at room temperature, which is 1–2 orders of magnitude lower than that in conventional heavy–metals‐based systems, due to the high SOT efficiency θSH = 1.16 of (BiSb)2Te3. Furthermore, all‐electrical field‐free writing is realized by the synergistic effect of a small spin‐transfer torque current during the SOT. The thermal stability factor (Δ = 66) shows the high retention time (>10 years) of the TI‐pMTJ device. This work sheds light to the future low‐power, high‐density, and high‐endurance/retention magnetic memory technology based on quantum materials.
Immunoaffinity‐Based Microfluidic Platform for Exosomal MicroRNA Isolation from Obese and Lean Mouse Plasma
Authors: Rodríguez‐Comas Júlia , Castaño Carlos , Ortega María Alejandra , Tejedera Ainoa , Fernandez‐González Míriam , Novials Anna , Párrizas Marcelina , Ramón‐Azcón Javier 
Published: May 2023

AbstractA new way of intercellular communication has been recently demonstrated, consisting of the controlled release of small vesicles loaded with bioactive factors (proteins, lipids, and nucleic acids chiefly amongst them) to the extracellular compartment. Importantly, these extracellular vesicles (EVs), including microvesicles and exosomes, regulate various physiological processes and, when disturbed, may contribute to the onset and progression of many diseases. Hence, they can be exploited as informative biomarkers to diagnose and monitor pathological conditions, including type 2 diabetes and associated metabolic disease. However, currently available techniques to isolate EVs lack reproducibility, effectiveness, and rapidity and require high amounts of starting samples, limiting their introduction in clinical practice. The objective of this work is to use a simple and easy‐to‐use microfluidic platform for capturing and quantifying a specific subpopulation of EVs from a small volume of plasma. As a proof‐of‐concept, the platform is tested with murine plasma. An analysis of the microRNA (miRNA) content of the isolated EVs is performed, detecting significant differences when comparing lean and obese mice. Thus, the device offers an easy, straightforward system to detect and analyze plasma‐derived EVs in the everyday clinical setting.
Insight on the Energy Storage Mechanism and Kinetic Dynamic of Manganese Oxide‐Based Aqueous Zinc‐Ion Batteries
Authors: Cui Xiaosha , Zhang Yaxiong , Zhang Junli , Xie Erqing , Fu Jiecai 
Published: May 2023

AbstractManganese oxide‐based (MO‐based) aqueous zinc ion batteries (AZIBs) are of great interest due to their high capacity, low cost, environmental friendliness, and low toxicity. However, to achieve commercialization of MO‐based AZIB, there are some issues mainly focused on cycling stability and capacity decay until now. The complexity of the energy storage mechanism and the physical and chemical properties of the MO itself are both hindering factors. Therefore, this review classifies and summarizes the energy storage mechanisms of MO‐based cathodes and hopes to guide the synthesis of MO‐based materials with excellent energy storage performance. And the kinetic assessment methods involve in the study of the MO‐based AZIB energy storage mechanism are categorized and highlighted. Moreover, the ideas of the current mechanisms mentioned are comprehensively discussed based on the advanced kinetic dynamics analyzing methods. In the last part of the review, a perspective outlook for the subsequent development and direction of MO‐based AZIB is made. This review will provide a guiding light for obtaining a high‐performance, commercially viable MO‐based AZIB.
A Porous Wrinkled Graphitic Carbon as Corrosion‐Resistant Carbon Support for Durable Fuel‐Cell Catalysts
Authors: Fan Pengshuo , Hao Yizhou , Xu Cong , Cao Yangfei , Huang Xianwu , Huang Jiahui , Lyu Xuanyu , Zhu Run , Lei Di , Li Wei , Yang Dong , Liang Haiwei , Chen Jianhao , Li Tongtao , Dong Angang 
Published: May 2023

AbstractThe lifespan of proton‐exchange membrane fuel cells heavily relies on the durability of the carbon support of cathode catalysts. However, commercial carbon supports like ketjenblack (KB) and Vulcan carbon (VC) face the challenge of balancing porosity, surface area, and electrochemical stability. To address this issue, a 3D porous wrinkled graphitic carbon (PWGC) is designed and synthesized using a catalyst‐free, plasma‐enhanced chemical vapor deposition approach. The resulting PWGC possesses a hierarchically porous structure with a high surface area, a high degree of graphitization, and exceptional corrosion resistance. As a result, the Pt/PWGC catalysts with the use of PWGC as the carbon support demonstrate superior high potential stability compared to those made with KB and VC as the carbon support. Additionally, a sacrificial layer strategy is introduced to further reduce PWGC corrosion, resulting in Pt@C/PWGC catalysts that show significantly improved durability in membrane electrode assembly tests. After 5K voltage cycles from 1.0 to 1.5 V, the retention of electrochemically active surface area approaches 56.8%, surpassing the 23.6% retention of commercial Pt/C catalysts tested under the same conditions.
A Review of Functional Hydrogels for Flexible Chemical Sensors
Authors: Zhou Pengcheng , Zhang Zongman , Mo Fan , Wang Yan 
Published: May 2023

AbstractHydrogels have drawn considerable attention in the field of flexible chemical sensors due to their unique 3D structure, high permeability, ion‐conductivity, and tissue‐like mechanical properties. These structures and properties allow them to be functionalized into diverse sensing components and respond to chemical signals in complex environments. Herein, an overview of functional hydrogel‐based flexible chemical sensors is provided. First, the representative hydrogel materials are introduced and the operating principles for flexible chemical sensors are discussed. Then, state‐of‐the‐art functional hydrogel‐based flexible chemical sensing applications are highlighted including gas sensors, humidity sensors, pH sensors, glucose sensors, wound monitoring, and others. Finally, major challenges and opportunities in this field are provided.
Muscle Injuries Induce a Prostacyclin‐PPARγ/PGC1a‐FAO Spike That Boosts Regeneration
Authors: Luo Lanfang , Chua Yan‐Jiang Benjamin , Liu Taoyan , Liang Kun , Chua Min‐Wen Jason , Ma Wenwu , Goh Jun‐Wei , Wang Yuefan , Su Jiali , Ho Ying Swan , Li Chun‐Wei , Liu Ke Hui , Teh Bin Tean , Yu Kang , Shyh‐Chang Ng 
Published: May 2023

AbstractIt is well‐known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigger muscle regeneration have remained unclear. Here, mass spectrometry imaging (MSI) is used to show that injured muscles induce a specific subset of prostanoids during regeneration, including PGG1, PGD2, and the prostacyclin PGI2. The spike in prostacyclin promotes skeletal muscle regeneration via myoblasts, and declines with aging. Mechanistically, the prostacyclin spike promotes a spike in PPARγ/PGC1a signaling, which induces a spike in fatty acid oxidation (FAO) to control myogenesis. LC–MS/MS and MSI further confirm that an early FAO spike is associated with normal regeneration, but muscle FAO became dysregulated during aging. Functional experiments demonstrate that the prostacyclin‐PPARγ/PGC1a‐FAO spike is necessary and sufficient to promote both young and aged muscle regeneration, and that prostacyclin can synergize with PPARγ/PGC1a‐FAO signaling to restore aged muscles’ regeneration and physical function. Given that the post‐injury prostacyclin‐PPARγ‐FAO spike can be modulated pharmacologically and via post‐exercise nutrition, this work has implications for how prostacyclin‐PPARγ‐FAO might be fine‐tuned to promote regeneration and treat muscle diseases of aging.
Facile synthesis of magnetically separable copper ferrite infused sulfonated graphene oxide nanocomposite with antimicrobial evaluation and photocatalytic performance under visible light
Authors: Sharma Shaily , Jakhar Prakash , Sharma Himanshu 
Published: May 2023

AbstractFacile approach has been employed for the synthesis of new copper ferrite impregnated sulfonated graphene oxide (SGO) nanocomposite via co‐precipitation technique. The newly created nanocomposite has exceptional qualities like a strong stability, large surface area, simple as well as effective recoverability. Structure, composition, and morphology of CuFe2O4@SGO nanocomposite were analyzed by fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscope (SEM), energy dispersive X‐Ray (EDX), X‐ray diffraction (XRD), and thermogravimetric analysis (TGA) techniques. The results presented the decoration of CuFe2O4 nanoparticles decorated uniformly upon the SGO sheets. Presently, photocatalytic efficiency of synthesized nanocomposite has been assessed for the deterioration of methyl violet 2B (MV) dye. On the effectiveness of dye degradation, the impacts of variables including initial dye concentration, catalyst loading, and visible light exposure have been studied. The photocatalytic data show that 97% of dye was degraded in merely 90 min. CuFe2O4@SGO nanocomposite was easily recyclable and hence it shows future scope as an inexpensive and alternate approach for removal of dye. The results of antimicrobial data evaluated that outstanding antibacterial data counter to Escherichia coli, Bacillus subtilis, and excellent antifungal data counter to Candida albicans was perceived.
Improvement of shrinkage reducing performance of polycarboxylate superplasticizer by butyl acrylate and its mechanism
Authors: Ge Haosheng , Sun Zhenping , Zheng Kunpeng , Lu Zichen , Yang Haijing , Zhang Ting 
Published: May 2023

AbstractA series of polycarboxylate superplasticizers (PCEs) with different molecular structures and shrinkage reducing performance were synthesized by modifying PCE with butyl acrylate (BA), and their molecular structures were characterized. The influence of BA on the dispersion and shrinkage reducing performance of PCEs and the influence of PCEs grafting different ration of BA on the hydration of cement were investigated in detail. Furthermore, the mechanisms of BA improving PCE shrinkage reducing performance were emphatically analyzed. The results showed that: (1) BA was successfully grafted into the molecular structures of PCEs and the expected molecular structures were obtained by polymerization. (2) BA has little effect on the dispersion of PCEs, but it will affect the hydration process of cement paste mixed with PCEs and significantly improve the shrinkage reducing performance of PCEs. (3) After grafting BA monomer into PCE, the surface tension of PCE solution decreased and the evaporation rate of alkaline solution mixed with PCE also significantly slowed down. Moreover, the retention capacity of pore water of cement paste mixed with PCE was improved. These three reasons were considered to be the main mechanisms of BA improving the shrinkage reducing performance of PCE.