bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing a novel Catfish flow restoration device and the Solitaire stent retriever for thrombectomy revascularisation in emergent largevessel occlusion stroke: a prospective randomised controlled study
Authors: Luo Gang , Yan Xiaoyan , Xiao Guodong , Wei Liping , Nai bi jiang Ya li kun , Ma Rongyao , Chen Wenhuo , Fang Chun , Zhou Zhiming , Wan Jieqing , Peng Ya , Zhang Guilian , Zhao Junfeng , Li Li , Yuan Haicheng , Wu Jin , Li Bing , Zhang Fan , Cheng Yuhong , Gao Feng , Miao Zhongrong 
Published: April 2023

BackgroundThe Catfish stent retriever is a newly developed mechanical thrombectomy device for rapid recanalisation in emergent large vessel occlusion (ELVO) stroke. The current trial aimed to assess whether the Catfish stent retriever is non-inferior to the Solitaire stent retriever in terms of outcomes in ELVO stroke.MethodsThis was a randomised, prospective, parallel-group, multicentre, open-label, non-inferiority study conducted at 18 sites in China. The primary outcome was the proportion of cases with successful recanalisation (modified thrombolysis in cerebral infarction score of 2b or 3) following the procedure. Secondary efficacy outcomes included the National Institutes of Health Stroke Scale scores at 24 hours and 7 days or discharge if earlier, time from artery puncture to successful recanalisation and good clinical outcome (modified Rankin scale score ≤2) at 90 days. Safety outcomes included symptomatic intracranial haemorrhage, all cause-death and severe adverse events at 90 days.ResultsBetween 3 March 2019 and 5 June 2021, 118 and 120 patients were randomly allocated to the Catfish and Solitaire groups, respectively. The primary endpoint after all endovascular procedures was non-inferior in the Catfish group (88.5%, 100/113) than in the Solitaire group (87.7%, 100/114), with a rate difference (RD) of 0.78% (95% CI –7.64 to –9.20; p=0.001). Sensitivity analysis only considering the per-protocol set also yielded similar results, with an RD of 0.83% (95% CI –7.03 to –8.70; p<0.001). Additionally, the proportions of cases with good clinical outcomes (47.8% vs 50.0%, p=0.739) and all-cause death rates (17.7% vs 18.8%, p=0.700) were similar in both groups at 90 days.ConclusionsThe Catfish stent retriever is an effective and safe device for endovascular recanalisation in ELVO stroke.Trial registration numberNCT03820882.
Lower extremity muscle strength equation of older adults assessed by Five Time Sit to Stand Test (FTSST)
Authors: Tapanya Weerasak , Sangkarit Noppharath , Amput Patchareeya , Konsanit Saisunee 
Published: April 2023

Background: The decline in lower limb muscle strength, one of the risk factors for falling in the older adults, puts older persons at an increased risk of falling. The assessment of the lower limb muscle strength is very important. Objective: The purpose of this study was to construct the equation for predicting knee extensor muscle strength based on demographic data and the results of the Five-Time Sit-to-Stand Test (FTSST). Methods: A total of 121 healthy elders (mean age [Formula: see text]) were asked to complete the FTSST and submit the demographic information. By using a stationary push–pull dynamometer, the knee extensor strength of each participant was assessed. The multiple regression analysis was used to explore knee extensor strength prediction equation. Results: The findings demonstrated that the knee extensor strength equation was developed using variables obtained from gender, weight, and time to complete the FTSST. The equation was found to have a high correlation ([Formula: see text]) and 70.1% estimation power. Its formula was as follows: Knee extensor [Formula: see text] (gender; [Formula: see text] or [Formula: see text])[Formula: see text][Formula: see text][Formula: see text]0.189 (weight)[Formula: see text]−[Formula: see text]2.617 (time to complete the FTSST). However, there was an estimating error in this equation of 4.72[Formula: see text]kg. Conclusion: The determining factors influencing knee extensor strength, which can be utilized to estimate the strength in elderly individuals, are demographic variables including gender, weight, and the time taken to complete the FTSST.
Microwave Drying Modelling of Stevia rebaudiana Leaves Using Artificial Neural Network and Its Effect on Color and Biochemical Attributes
Authors: Kalsi Baldev Singh , Singh Sandhya , Alam Mohammed Shafiq , Bhatia Surekha 
Published: April 2023

Stevia rebaudiana has grown in popularity and consumption across the world as an excellent natural sweetener due to its 300 times sweetness than sugar. Since Stevia leaves are often used in their dried state, the drying process has an inevitable effect on the attributes of finished product. In this study, Stevia leaves were microwave dried at five different levels of powers ranging from 180 to 900 W to evaluate the influence of power levels on moisture ratio (MR), drying rate and time, effective moisture diffusivity, specific energy consumption (SEC), color, and biochemical characteristics. Among the five selected thin layer models for evaluating the drying behavior, the semiempirical page model described the drying kinetics very well with R2 > 0.997. The effective diffusivity increased from

3.834
×

10

−
11

to

1.997
×

10

−
10

m2/s with increasing microwave power, while SEC first increased till 320 W to a value of 9.77 MJ/kg and then followed a decreasing trend. Furthermore, multilayer feed forward (MLF) artificial neural network (ANN) using backpropagation algorithm was used to predict the moisture ratio of Stevia leaves during microwave drying. The result showed that the ANN model with 15 neurons in 1 hidden layer could predict the MR with a high R2 value (0.999). Thus, ANN modelling can successfully be used as an effective tool for predicting drying kinetics of samples. Furthermore, the color properties showed significant differences between fresh and dried samples except for the hue angle, and the variation in their values was not affected by the microwave dryer’s power output. At 720 W power level, the highest content of stevioside (11.84 mg/g) and rebaudioside A (7.11 mg/g) along with maximum retention of ascorbic acid (∼86%) was observed, while the highest total phenol content (56.98 mg GAE/g) and antioxidant capacity (74.22%) was reported in microwave dried samples at 900 W.
Targeting Wnt-ß-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling
Authors: Nayakanti Sreenath Reddy , Friedrich Aleksandra , Sarode Poonam , Jafari Leili , Maroli Giovanni , Boehm Mario , Bourgeois Alice , Grobs Yann , Khassafi Fatemeh , Kuenne Carsten , Guenther Stefan , Dabral Swati , Wilhelm Jochen , Weiss Astrid , Wietelmann Astrid , Kojonazarov Baktybek , Janssen Wiebke , Looso Mario , de Man Frances , Provencher Steeve , Tello Khodr , Seeger Werner , Bonnet Sebastien , Savai Rajkumar , Schermuly Ralph T. , Pullamsetti Soni Savai 
Published: April 2023

Background:
The ability of the right ventricle (RV) to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. At present, there are no specific treatments available to prevent RV failure, except for heart/lung transplantation. The wingless/int-1 (Wnt) signaling pathway plays an important role in the development of the RV and may also be implicated in adult cardiac remodeling.

Methods:
Molecular, biochemical, and pharmacological approaches were used both in vitro and in vivo to investigate the role of Wnt signaling in RV remodeling.

Results:
Wnt/β-catenin signaling molecules are upregulated in RV of patients with pulmonary arterial hypertension and animal models of RV overload (pulmonary artery banding-induced and monocrotaline rat models). Activation of Wnt/β-catenin signaling leads to RV remodeling via transcriptional activation of FOSL1 and FOSL2 (FOS proto-oncogene [FOS] like 1/2, AP-1 [activator protein 1] transcription factor subunit). Immunohistochemical analysis of pulmonary artery banding -exposed BAT-Gal (β-catenin-activated transgene driving expression of nuclear β-galactosidase) reporter mice RVs exhibited an increase in β-catenin expression compared with their respective controls. Genetic inhibition of β-catenin, FOSL1/2, or WNT3A stimulation of RV fibroblasts significantly reduced collagen synthesis and other remodeling genes. Importantly, pharmacological inhibition of Wnt signaling using inhibitor of PORCN (porcupine O-acyltransferase), LGKK-974 attenuated fibrosis and cardiac hypertrophy leading to improvement in RV function in both, pulmonary artery banding - and monocrotaline-induced RV overload.

Conclusions:
Wnt- β-Catenin-FOSL signaling is centrally involved in the hypertrophic RV response to increased afterload, offering novel targets for therapeutic interference with RV failure in pulmonary hypertension.
Associations of Renal Function Trajectories and Long‐Term Cardiovascular Risks Among a Population Without Chronic Kidney Disease
Authors: Zhai Yuan‐Sheng , Cheng Yun‐Jiu , Deng Hai‐Wei , Li Jie , Peng Longyun , Gao Xiuren 
Published: April 2023

Background
The longitudinal trajectories of renal function have been associated with cardiovascular events in patients with chronic kidney disease (CKD). However, the change pattern of renal function in those without CKD has not yet been reported. We aim to explore patterns of renal function change in a non‐CKD population and its associated risks with cardiovascular outcomes.

Methods and Results
The present study analyzed data from 4 prospective cohorts and was restricted to participants without baseline CKD. The primary outcome was major adverse cardiovascular events, defined as a composite of myocardial infarction, chronic heart failure, stroke, and cardiovascular deaths. We used a group‐based trajectory model to identify latent groups and analyzed the associated risk with Cox regression models. The complete dates of this study were June 1, 2020, through January 1, 2021. The final sample comprised 23 760 participants (mean age, 58.63 [9.12] years, 10 618 men, and 17 799 White participants). During 20.56 years follow‐up, 8328 (35.05%) first major adverse cardiovascular events happened. Four trajectories in estimated glomerular renal function and 3 patterns of CKD progression were identified. Compared with subjects assigned to class I trajectory (high to mildly decreased group), the adjusted hazard ratios of major adverse cardiovascular events for class II (normal to mildly decreased group), class III (normal to moderately decreased group), and class IV (mildly to severely decreased group) were 1.11 (95% CI, 1.01–1.23), 1.27 (95% CI, 1.14–1.40), and 1.56 (95% CI, 1.38–1.77), respectively. Likewise, participants assigned to the slow and rapid progression groups had elevated HRs for major adverse cardiovascular events (1.75 [95% CI, 1.39–2.21] and 2.19 [95% CI, 1.68–2.86], respectively) when compared with the stable group. Findings were generally consistent in stratification analysis, but significant interaction effects by age and smoking status were detected.

Conclusions
In this study, we identified unique trajectory groups for renal function. These findings may signal an underlying high‐risk population and inspire future studies on individualized risk management.
Gabor and Non-Gabor Neural Representations Are Shared between Visual Perception and Mental Imagery
Authors: Huang Yingying , Pollick Frank , Liu Ming , Zhang Delong 
Published: April 2023

Abstract
Visual perception and mental imagery have been shown to share a hierarchical topological visual structure of neural representation, despite the existence of dissociation of neural substrate between them in function and structure. However, we have limited knowledge about how the visual hierarchical cortex is involved in visual perception and visual imagery in a unique and shared fashion. In this study, a data set including a visual perception and an imagery experiment with human participants was used to train 2 types of voxel-wise encoding models. These models were based on Gabor features and voxel activity patterns of high-level visual cortex (i.e., fusiform face area, parahippocampal place area, and lateral occipital complex) to predict activity in the early visual cortex (EVC, i.e., V1, V2, V3) during perception, and then tested with respect to the generalization of these models to mental imagery. Our results showed that during perception and imagery, activities in the EVC could be independently predicted by the Gabor features and activity of high-level visual cortex via voxel-wise encoding models, which suggested that perception and imagery might share neural representation in the EVC. We further found Gabor-specific and non-Gabor-specific patterns of neural response to stimuli in the EVC, which were shared by perception and imagery. These findings provide insight into the mechanisms of how visual perception and imagery share representation in the EVC.
Correlations between Visual Temporal Resolution and Individual Alpha Peak Frequency: Evidence that Internal and Measurement Noise Drive Null Findings
Authors: Deodato Michele , Melcher David 
Published: April 2023

Abstract
The brain organizes the continuous flow of sensory input by parsing it into discrete events. In the case of two flashes separated by a brief ISI, for example, perception may be of a single flash or two distinct flashes, depending on the ISI but also on the speed of processing. A number of studies have reported evidence that participants with a higher EEG peak alpha frequency are able to detect the presence of two flashes separated by short intervals, whereas those with slower alpha report only one flash. Other studies have not found this correlation. We investigated potential factors that might mask the relationship between individual alpha frequency and visual perception. We recorded resting-state EEG from a large sample of participants (n = 50) and measured the temporal resolution of visual perception with the two-flash fusion task. We found that individual alpha frequency over posterior channels predicted the two-flash fusion threshold, in line with previous studies, but this correlation was significant only when taking into account the steepness of the psychophysical curve of the two-flash task. Participants with a relatively shallow psychophysical curve, likely reflecting high sensory and/or decision noise, failed to show this relationship. These findings replicate previous reports of a correlation between alpha frequency and visual temporal resolution, while also suggesting that an explanation of two-flash fusion performance that neglects the role of internal noise might be insufficient to account for all individual differences.
Stimulus Onset Asynchrony Affects Weighting-related Event-related Spectral Power in Self-motion Perception
Authors: Townsend Ben , Legere Joey K. , v. Mohrenschildt Martin , Shedden Judith M. 
Published: April 2023

Abstract
Self-motion perception relies primarily on the integration of the visual, vestibular, proprioceptive, and somatosensory systems. There is a gap in understanding how a temporal lag between visual and vestibular motion cues affects visual–vestibular weighting during self-motion perception. The beta band is an index of visual–vestibular weighting, in that robust beta event-related synchronization (ERS) is associated with visual weighting bias, and robust beta event-related desynchronization is associated with vestibular weighting bias. The present study examined modulation of event-related spectral power during a heading judgment task in which participants attended to either visual (optic flow) or physical (inertial cues stimulating the vestibular, proprioceptive and somatosensory systems) motion cues from a motion simulator mounted on a MOOG Stewart Platform. The temporal lag between the onset of visual and physical motion cues was manipulated to produce three lag conditions: simultaneous onset, visual before physical motion onset, and physical before visual motion onset. There were two main findings. First, we demonstrated that when the attended motion cue was presented before an ignored cue, the power of beta associated with the attended modality was greater than when visual–vestibular cues were presented simultaneously or when the ignored cue was presented first. This was the case for beta ERS when the visual-motion cue was attended to, and beta event-related desynchronization when the physical-motion cue was attended to. Second, we tested whether the power of feature-binding gamma ERS (demonstrated in audiovisual and visual–tactile integration studies) increased when the visual–vestibular cues were presented simultaneously versus with temporal asynchrony. We did not observe an increase in gamma ERS when cues were presented simultaneously, suggesting that electrophysiological markers of visual–vestibular binding differ from markers of audiovisual and visual–tactile integration. All event-related spectral power reported in this study were generated from dipoles projecting from the left and right motor areas, based on the results of Measure Projection Analysis.
Towards a Genealogy of Thomas Kuhn’s Semantics
Authors: Melogno Pablo , Giri Leandro 
Published: April 2023

Abstract
This paper explores Thomas Kuhn’s intellectual history by examining sources that have been understudied so far: the Lowell Lectures of 1951 (The Quest for Physical Theory) and the hitherto unpublished Notre Dame Lectures of 1980. The analysis of these texts aims to reconstruct Kuhn’s development of a semantics that can account for scientific progress. This analysis will show that the alleged “linguistic turn” attributed to the author is actually a renewed interest in problems that existed well before publishing The Structure of Scientific Revolutions.
Dealing with Molecular Complexity. Atomistic Computer Simulations and Scientific Explanation
Authors: Schweer Julie , Elstner Marcus 
Published: April 2023

Abstract
Explanation is commonly considered one of the central goals of science. Although computer simulations have become an important tool in many scientific areas, various philosophical concerns indicate that their explanatory power requires further scrutiny. We examine a case study in which atomistic simulations have been used to examine the factors responsible for the transport selectivity of certain channel proteins located at cell membranes. By elucidating how precisely atomistic simulations helped scientists draw inferences about the molecular system under investigation, we respond to some concerns regarding their explanatory power. We argue that atomistic simulations can be tools for managing molecular complexity and for systematically assessing how the occurrence of the explanandum is sensitive to a range of factors.
Oecumene in het Midden-Oosten
Authors: Teule Herman G.B. 
Published: April 2023

Ecumenism in the Middle-East Same historical investigations (eighth-thirteenth centuries)
The author discusses, for the period of roughly the Abbasid Caliphate, three different mentalities regarding ecumenism. Firstly, the attitude that the absolute norm for truth can be found only in one’s own ecclesiastical community; other Christians can only be regarded as heretics. No attempt is made to understand their theology. Secondly, the attitude that on the basis of rational arguments one tries to enter into a respectful dialogue with other Christians, be it that ultimately truth is still thought to be present only in the own community. Thirdly, the relativization of one’s traditional theological terminology, which opens the way to finding validity also in the theological expression of ‘other’ Christians.
The third attitude is mainly, but not exclusively, found in Christian Arabic texts. It seems a logical, further step in the process that Christians in the Middle East, from the ninth century onwards, made extensive use of a philosophical method and argumentation rather than that it would be due to a Muslim environment.
A Technical Overview of the North Carolina ECONet
Authors: Saia Sheila M. , Heuser Sean P. , Neill Myleigh D. , LaForce IV William A. , McGuire John A. , Dello Kathie D. 
Published: April 2023

Abstract
Regional weather networks—also referred to as mesonets—are imperative for filling in the spatial and temporal data gaps between nationally supported weather stations. The North Carolina Environment and Climate Observing Network (ECONet) fills this regional role; it is a mesoscale network of 44 (as of 2023) automated stations collecting 12 environmental variables every minute across North Carolina. Measured variables include air temperature, precipitation, relative humidity, barometric pressure, wind speed, wind direction, total solar radiation, photosynthetically active solar radiation, soil temperature, soil moisture, leaf wetness index, and black globe temperature. All data undergo quality control procedures and are made freely available to the public via data portals hosted by the State Climate Office of North Carolina at North Carolina State University. This paper provides a technical overview of ECONet, including a description of the siting criteria, station maintenance procedures, data quality control procedures, and data availability. We also summarize unique aspects of ECONet data collection as well as innovative research and applications that rely on ECONet data. ECONet data are used by many sectors including, but not limited to, emergency management, natural resources management, public health, agriculture, forestry, science education, outdoor recreation, and research. ECONet data and data-powered applications offer valuable insights to local, regional, and federal partners, yet opportunities to expand ECONet research and applications remain.

Significance Statement
This paper explains the ongoing and emerging impacts of a statewide weather station network called the North Carolina Environment and Climate Observing Network (ECONet). ECONet consists of 44 (as of 2023) automated stations located across the state. Each station collects 12 environmental variables every minute. ECONet data and data-powered applications offer valuable insights to local, regional, and federal partners. There are many opportunities to expand ECONet-based research and applications.
A Simple Method for Estimating Horizontal Diffusivity
Authors: Olivé Abelló Anna , Pelegrí Josep L. , Machín Francisco 
Published: April 2023

Abstract
A common dilemma for oceanographers is the choice of horizontal diffusivity. There is no single answer as we could argue that diffusion depends precisely on those processes that cannot be sampled or modeled. Here we propose the radial offset by diffusion (ROD) method as a simple model-dependent approach for estimating these coefficients, and show its application for the southwestern South Atlantic. The method compares actual displacements of field drifters with numerical trajectory predictions. The observed–predicted differences in radial positions (radial offsets), which respond to diffusive motions not captured by the numerical model, are reproduced with a one-dimensional radial-diffusive solution through a proper selection of the diffusion coefficient. The method is tested at eight depths, from the sea surface down to 2000 m, using several drifter datasets and the Parcels software applied to the GLORYS12v1 (1/12° daily) velocity outputs. In all cases the radial offsets show Gaussian distributions that are well reproduced by the radial diffusive solution. Maximum diffusivities of 4630–4980 m2 s−1 happen in the upper 200 m of the water column and minimum values of 1080–1270 m2 s−1 occur between 1400 and 2000 m. The 15-m diffusivity is fairly constant in latitude (3850–5270 m2 s−1), but the 1000-m diffusivity decreases from 1640 to 1820 m2 s−1 north of the Polar Front to 530 m2 s−1 south of the Southern Boundary. A comparison with other diffusivity studies validates the good adequacy of the ROD method for numerical and field applications.