bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic Sleeve Gastrectomy Versus One Anastomosis Gastric Bypass in Adolescents With Obesity
Authors: Sorek Adi , Eldar Sukhotnik Meron , Cohen Shlomi , Mazkeret Mayer Inbar , Sukhtnik Igor , Lubetzky Ronit , Moran-Lev Hadar 
Published: March 2023

Objective:
Large studies comparing outcomes between laparoscopic sleeve gastrectomy (LSG) and one anastomosis gastric bypass (OAGB) are scarce and involve adult populations. The aim of the study was to compare perioperative, early postoperative, and 1-year postoperative outcomes of adolescents with obesity who underwent LSG or OAGB surgery.

Methods:
The medical records of adolescents with obesity who underwent LSG or OAGB at the Tel Aviv Sourasky Medical Center from January 2017 to January 2021 were retrospectively reviewed. Data on their gastrointestinal (GI) symptoms and postoperative quality of life were obtained by a telephone interview.

Results:
Included were 75 adolescents (median [interquartile range, IQR] age 17.3 [16–18] years) of whom 22 underwent OAGB and 53 underwent LSG. There were no significant preoperative group differences in age, sex, and body mass index score. A low rate of perioperative (5.7% vs 0) and postoperative complication (15.1% vs 10%) with no statistical differences between LSG and OAGB group, respectively, was noted. At 12 months, the percent excessive weight loss + IQR was 42.40% [30.00, 45.00] and 38.00% [33.550, 44.20] in the LSG and OAGB group, respectively (P = NS). The results of the Pediatric Quality of Life Inventory Gastrointestinal Symptoms scale revealed significantly less food limitation and heartburn after OAGB compared to LSG (food limitation 71.63 vs 53.85 and heartburn 83.654 vs 61.6, P = 0.03 and P = 0.029, respectively).

Conclusions:
Both surgeries are effective and safe for weight loss in the adolescent population. OAGB was associated with significantly fewer GI symptoms compared to LSG.
Taylor–Couette flow for astrophysical purposes
Authors: Ji H. , Goodman J. 
Published: March 2023

A concise review is given of astrophysically motivated experimental and theoretical research on Taylor–Couette flow. The flows of interest rotate differentially with the inner cylinder faster than the outer, but are linearly stable against Rayleigh’s inviscid centrifugal instability. At shear Reynolds numbers as large as106, hydrodynamic flows of this type (quasi-Keplerian) appear to be nonlinearly stable: no turbulence is seen that cannot be attributed to interaction with the axial boundaries, rather than the radial shear itself. Direct numerical simulations agree, although they cannot yet reach such high Reynolds numbers. This result indicates that accretion-disc turbulence is not purely hydrodynamic in origin, at least insofar as it is driven by radial shear. Theory, however, predicts linear magnetohydrodynamic (MHD) instabilities in astrophysical discs: in particular, the standard magnetorotational instability (SMRI). MHD Taylor–Couette experiments aimed at SMRI are challenged by the low magnetic Prandtl numbers of liquid metals. High fluid Reynolds numbers and careful control of the axial boundaries are required. The quest for laboratory SMRI has been rewarded with the discovery of some interesting inductionless cousins of SMRI, and with the recently reported success in demonstrating SMRI itself using conducting axial boundaries. Some outstanding questions and near-future prospects are discussed, especially in connection with astrophysics.This article is part of the theme issue ‘Taylor–Couette and related flows on the centennial of Taylor’s seminalPhilosophical Transactionspaper (part 2)’.
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Authors: Watanuki Shintaro , Kobayashi Hiroshi , Sugiura Yuki , Yamamoto Masamichi , Karigane Daiki , Shiroshita Kohei , Sorimachi Yuriko , Fujita Shinya , Morikawa Takayuki , Koide Shuhei , Oshima Motohiko , Nishiyama Akira , Murakami Koichi , Haraguchi Miho , Tamaki Shinpei , Yamamoto Takehiro , Yabushita Tomohiro , Tanaka Yosuke , Nagamatsu Go , Honda Hiroaki , Okamoto Shinichiro , Goda Nobuhito , Tamura Tomohiko , Nakamura-Ishizu Ayako , Suematsu Makoto , Iwama Atsushi , Suda Toshio , Takubo Keiyo 
Published: March 2023

AbstractMetabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cells such as hematopoietic stem cells (HSCs). Here, we aimed to identify the key metabolic enzymes that define differences in glycolytic metabolism between steady-state and stress conditions in HSCs and elucidate their regulatory mechanisms. Through quantitative13C metabolic flux analysis of glucose metabolism using high-sensitivity glucose tracing and mathematical modeling, we found that HSCs activate the glycolytic rate-limiting enzyme phosphofructokinase (PFK) during proliferation and oxidative phosphorylation (OXPHOS) inhibition. Real-time measurement of adenosine triphosphate (ATP) levels in single HSCs demonstrated that proliferative stress or OXPHOS inhibition led to accelerated glycolysis via increased activity of PFKFB3, the enzyme regulating an allosteric PFK activator, within seconds to meet ATP requirements. Furthermore, varying stresses differentially activated PFKFB3 via PRMT1-dependent methylation during proliferative stress and via AMPK-dependent phosphorylation during OXPHOS inhibition. Overexpression ofPfkfb3induced HSC proliferation and promoted differentiated cell production, whereas inhibition or loss ofPfkfb3suppressed them. This study reveals the flexible and multilayered regulation of HSC glycolytic metabolism to sustain hematopoiesis under stress and provides techniques to better understand the physiological metabolism of rare hematopoietic cells.Key PointsCombined isotope tracing, mathematical modeling, and single cell ATP analysis enable high-resolution evaluation of blood cell metabolism.Under stress, HSCs quickly accelerate glycolysis to meet ATP demands and maintain hematopoiesis via context-dependent PFKFB3 activation.
A pragmatist neoclassical accounting research agenda for identifiable intangibles
Authors: Rutherford Brian A. 
Published: March 2023

PurposeThis paper offers a way of revivifying classical accounting research in the form of a pragmatist neoclassical programme with a sound epistemological underpinning.Design/methodology/approachThe paper draws on a pragmatist perspective on financial accounting and accounting research springing from John Dewey's theory of inquiry.FindingsAlthough a pragmatist underpinning does not entail specific methodological prescriptions, it can provide fruitful insights in research design. The paper discusses the structure and content of a research programme drawing on a pragmatist underpinning and sets out proposals for a practical research agenda. Although the agenda is shaped around the topic of identifiable intangibles, much of the paper has substantially wider relevance.Research limitations/implicationsThe approach justifies a revival in scholarly research employing classical methods and directed at improving accounting methods and standards.Practical implicationsThe approach would promote closer engagement between scholarly accounting and practitioners such as standard-setters, making some contribution to closing the widely acknowledged gap between research and practice.Originality/valueThe paper offers a neoclassical programme of research drawing considerably more extensively on pragmatist philosophy than did theorisation in the classical period.
A pricing and transshipment hybrid strategy for perishable product in two external scenarios for supply disruption
Authors: Sun Qi , Gao Yaya , Lu Qihui , Yan Yingyi 
Published: March 2023

PurposeDifferent external supply scenarios faced by the retailers will affect their choice of strategy when supply is disrupted and becomes far less than demand, urgently. This study focuses on analyzing both demand and supply side response strategies to meet customer demand and reduce the impact of the shortage during supply disruptions.Design/methodology/approachAccording to the quantity of products that the external market can provide, the external supply scenarios were divided into sufficient-type external supply and learning-type external supply. A two-echelon perishable goods supply chain was analyzed, and three kinds of contingency strategy models for downstream retailers were investigated. First, in the sufficient external supply scenario, the optimal price and transshipment quantity to maximize retailer's profits is discussed. Second, in the scenario of learning-type external supply, this study analyzes the optimal decision in three mechanisms of the hybrid strategy and their application: price priority mechanism, quantity priority mechanism and price–quantity balance mechanism. Furthermore, the influence of penalty cost and supply on the priority orders of different mechanisms was studied.FindingsResults show that comparing the two pure strategies (pricing strategy and transshipment strategy)it was noted that the hybrid strategy produces the best results in sufficient-type external supply scenario. In the learning-type external supply scenario, a numerical study has shown the existence of three areas in case of penalty cost and supplier's capacity, and each areas has different priority orders of the three mechanisms. Under the situation of learning external supply, the retailer's optimal strategy is affected by parameters such as penalty cost and supply volume.Originality/valueThe main innovation of the work lies in the following: First; the external supply situation was divided into sufficiency type and learning type, which improves the external situation faced by retailers after the outbreak of emergencies, helps retailers understand the external situation, conforms to the actual situation and has certain practical application value. Second; in the context of learning external supply, there are three coping strategies for retailers, including: Price priority mechanism, Quantity priority mechanism and Pricing and transshipment balance mechanism. This will help retailers make strategic choices, make more scientific management decisions and improve the supply chain emergency management theory. Third; the demand side response was managed through the change of external supply during supply side recovery period and supply disruption. The proposed model enables managing and analyzing supply disruption efficiently and effectively via handling uncertainty by considering all aspects of decision-making process. The proposed model can be applied in various fields such as vegetable and fruit, fresh food, etc.
Exploring perceived impact of caregiving and coping strategies adopted by family caregivers of people with schizophrenia: a qualitative study in Enugu, South East Nigeria
Authors: Mbadugha Chisom Joy , Ogbonnaya Ngozi Phoebe , Iheanacho Peace Njideka , Omotola Ngozi Joy , Ogbonna Pleasure Nwakaego , Anetekhai Chinenye Juliet 
Published: March 2023

PurposeSchizophrenia, a chronic mental disorder, poses enormous threat to the individual, family and society. The advent of deinstitutionalization of the mentally ill transferred the burden of care to families especially close relatives. Few studies have described the families' subjective views in this context. Hence, this study aimed to explore impacts of caregiving and coping strategies for family caregivers of patients with schizophrenia in Enugu, South East Nigeria.Design/methodology/approachA descriptive qualitative design was employed, and 14 family caregivers of individuals with schizophrenia attending federal neuropsychiatric hospital Enugu were purposively selected. A semi-structured interview guide was used to generate information, and the transcribed data were content analyzed using a thematic approach.FindingsThree major themes and 16 subthemes were derived to reflect the perceived impact of caregiving and coping strategies of family caregivers, which include burden of care (physical-self neglect, ill health, sleep deprivation; psychological-gross irritability, ruminations; social-stigmatization, social restrictions, diminished connections, reduced productivity); positive aspects (heightened understanding; empathetic attitude, strengthened ties) and adaptive resources (acceptance, optimism, social support, spiritual devotion).Originality/valueFamily caregivers of individuals with schizophrenia experience bio-psychosocial burden as a result of caregiving. Coping with challenges of caregiving can prevent distress and burnout. Hence, there is need for mental health professionals to recognize caregivers as person in need of emotional and practical support and care for the mentally ill in the context of a family-centered approach.
Native vegetation embedded in landscapes dominated by corn and soybean improves honey bee health and productivity
Authors: Zhang Ge , Murray Caroline J. , St. Clair Ashley L. , Cass Randall P. , Dolezal Adam G. , Schulte Lisa A. , Toth Amy L. , O'Neal Matthew E. 
Published: March 2023

Abstract

Balancing demand for food while supporting biodiversity and ecosystem services in landscapes committed to crop production may require integrating conservation with agriculture. Adding strips of diverse, native, perennial vegetation, through the recently created prairie strips practice of the U.S. Conservation Reserve Program, into annual cropland reduces soil and nutrient loss, and supports more diverse and abundant communities of birds and insects, including native pollinators. It remains unclear if prairie strips can reverse declines in the health and productivity of the exotic honey bee in the U.S.

This study determined if prairie strips provide floral resources to honey bees and support colony vigour, in a highly farmed landscape with limited perennial habitat. We hypothesized that honey bee health and productivity would be improved if given access to prairie strips, and this hypothesis was tested in a multi‐year, replicated, longitudinal study on commercial, conventional farms committed to corn and soybean production with and without prairie strips. We predicted that prairie strips would have more diverse flowering plants, and colonies located in these strips would be healthier and more productive than colonies kept at farms without purposefully established native vegetation (i.e. control fields).

We found that prairie strips had more diverse flowering plants and abundant floral resources than control fields. Colonies kept at fields with prairie strips collected 50% more pollen during the growing season (June–September), had a 24% larger end‐of‐season worker bee populations, and 20% higher overwinter survival than colonies kept at control fields. Furthermore, colonies kept at prairie strips were 24% heavier when they reached their peak‐weight in August, an indicator of honey production.

Honey bees collected pollen from flowering plants found in prairie strips, revealing the potential for interactions with wild pollinators. However, this was limited to 50% of the taxa in prairie strips, suggesting honey bees may not deplete all of the food resources simultaneously used by wild pollinators.

Synthesis and applications. Our results suggest that efforts to enhance habitat diversity within croplands with native plants increase honey bee health and productivity while providing multiple additional ecosystem services important to agriculture.
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice
Authors: DeBaker Margot C. , Mitten Eric H. , Rose Timothy R. , Marron Fernandez de Velasco Ezequiel , Gao Runbo , Lee Anna M. , Wickman Kevin 
Published: March 2023

Background and PurposeDrugs of abuse, including alcohol, increase dopamine in the mesocorticolimbic system via actions on dopamine neurons in the ventral tegmental area (VTA). Increased dopamine transmission can activate inhibitory G protein signalling pathways in VTA dopamine neurons, including those controlled by GABAB and D2 receptors. Members of the R7 subfamily of regulator of G protein signalling (RGS) proteins can regulate inhibitory G protein signalling, but their influence on VTA dopamine neurons is unclear. Here, we investigated the influence of RGS6, an R7 RGS family memberthat has been implicated in the regulation of alcohol consumption in mice, on inhibitory G protein signalling in VTA dopamine neurons.Experimental ApproachWe used molecular, electrophysiological and genetic approaches to probe the impact of RGS6 on inhibitory G protein signalling in VTA dopamine neurons and on binge‐like alcohol consumption in mice.Key ResultsRGS6 is expressed in adult mouse VTA dopamine neurons and it modulates inhibitory G protein signalling in a receptor‐dependent manner, tempering D2 receptor‐induced somatodendritic currents and accelerating deactivation of synaptically evoked GABAB receptor‐dependent responses. RGS6−/− mice exhibit diminished binge‐like alcohol consumption, a phenotype replicated in female (but not male) mice lacking RGS6 selectively in VTA dopamine neurons.Conclusions and ImplicationsRGS6 negatively regulates GABAB‐ and D2 receptor‐dependent inhibitory G protein signalling pathways in mouse VTA dopamine neurons and exerts a sex‐dependent positive influence on binge‐like alcohol consumption in adult mice. As such, RGS6 may represent a new diagnostic and/or therapeutic target for alcohol use disorder.
Media use and the development of racial attitudes among U.S. youth
Authors: Ward L. Monique , Bridgewater Enrica 
Published: March 2023

AbstractBecause media provide a steady stream of models, they are especially poised to offer formative information about race. Yet although U.S. youth consume approximately 7 h of media daily, we know little about how media use contributes to their developing racial attitudes. Instead, research has focused mainly on adults, and studies of youth have developed along separate tracks for youth who are White and BIPOC (Black, Indigenous, and people of color). In this article, we first analyze the lack of attention to media effects on the development of racial attitudes, despite their assumed prominence as socializers. Then we summarize research on youth of color and White youth. We conclude with suggestions for building a comprehensive research agenda, including addressing gaps in the associations tested, considering more nuanced assessments of race and media, and integrating approaches across fields.
Vascularized organ bioprinting: From strategy to paradigm
Authors: Wang Heran , Liu Xin , Gu Qi , Zheng Xiongfei 
Published: March 2023

AbstractOver the past two decades, 3D bioprinting has become a popular research topic worldwide, as it is the most promising approach for manufacturing vascularized organs in vitro. However, transitioning from bioprinting of simple tissue models to real biomedical applications is still a challenge due to incomplete interdisciplinary theoretical knowledge and imperfect multi‐technology integration. This review examines the goals of vasculature manufacturing and proposes new strategic objectives in three stages. We then outline a bidirectional manufacturing strategy consisting of top‐down reconstruction (bioprinting) and bottom‐up regeneration (cellular behaviour). We also provide an in‐depth analysis of the four aspects of design, ink, printing and culture. Furthermore, we present the ‘construction‐comprehension cycle’ research paradigm and the ‘math‐model‐based batch insights generator’ research paradigm for the future, which may have the potential to revolutionize the biomedical field.
Clinicopathological features and immunophenotype of Silva pattern system in endocervical adenocarcinoma
Authors: Zeng Chao , Wu Jin‐ke , Lu Xiaofang 
Published: March 2023

AbstractThe aim of this study was to investigate the correlation between Silva pattern system and clinicopathological features of endocervical adenocarcinoma. Moreover, it was to find molecular markers helpful for Silva classification, and thus we also explored the expression levels of invasion, adhesion and proliferation biomarkers in cases of Silva non‐invasive and invasive types. The survival based on Silva pattern system was analysed by Kaplan–Meier survival analysis, Log‐rank test and a COX risk proportionality model. Sixty samples were chosen to detect the MMP‐2, MMP‐9, u‐PA, E‐cadherin, β‐catenin, EGF, TGF‐α, HDGF, c‐Met and RGN expression by immunohistochemistry. Multivariate analysis showed that pattern A/pattern B/pattern C Silva pattern system provided independent risk factors for prognosis. Our results found the levels of MMP‐2, MMP‐9 and u‐PA were significantly higher in endocervical adenocarcinoma with destructive growth than in the nondestructive group. The levels of E‐cadherin and β‐catenin were significantly lower in endocervical adenocarcinoma with destructive growth than in the nondestructive group. The levels of EGF, TGF‐α and HDGF were significantly higher in endocervical adenocarcinoma with destructive growth than in the nondestructive group. Compared with ‘non‐invasive/invasive Silva pattern’, this study suggests ‘pattern A/pattern B/pattern C Silva pattern’ could be a better criteria for predicting the prognosis. Furthermore, the dual‐marker combination of ‘MMP‐2 and u‐PA’ and ‘E‐cadherin and β‐catenin’ is very important in the diagnosis of Silva pattern classification.
Indwelling catheter patient experiences and the potential usability and acceptance of the T‐Control® prototype urinary catheter
Authors: Toledo‐Chavarri A. , Bassas‐Parga A. , Endrenyi S. , Luque M. , Bezos‐Daleske C. , Reyero V. , Serrano‐Aguilar P. , Batista‐Miranda J. E. 
Published: March 2023

AbstractThe aim of this study was to analyse the experience of users of indwelling bladder catheters and evaluate the anticipated usability of a prototype of the T‐Control® urinary catheter (without being inserted) by patients who were able to compare the differences between the T‐Control® prototype and other urinary catheters and urinary catheter accessories. A qualitative study was conducted with people who had lived with an indwelling urinary catheter for at least 1 week. Two user‐centred design techniques were applied: patient experience trajectory map and Think Aloud, a method where the participants were able to express their previous experiences, expectations and preferences while manipulating the devices. The experiential trajectory was collected based on a semi‐structured following interviews. Participants were able to manipulate the new T‐Control® and, based on their previous experiences, compare the potential usability of T‐control® with Foley‐type catheter and its accessories All the participants stated that they had experienced negative emotions concerning bladder catheterisation during the trajectory of use, from the initial prescription and adaptation to the follow‐up, and the forced life changes that a permanent catheterisation implies. The most frequent emotions were rejection and sadness. The new T‐Control® device could potentially improve the patient experience, as all participants perceived advantages related to the closure system, ease of use, safety and discretion. Participants also noted its closure system as an advantage and highlighted its ease of use, although one‐handed operation required some learning. Catheters currently on the market are functional, but some patients do not always have a satisfactory experience. This might negatively affect their quality of life, so there is a wide market opportunity for new devices that improve clinical and psychological care. Based on patient evaluation, the new T‐Control® device with a built‐in valve could provide benefits for patients.