bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCL8 and JAK2, modulated by apigenin, are two regulators in the pathogenesis of diabetic foot ulcer
Authors: Feng Xuan , Xu Zhihai 
Published: January 2025

Abstract

Background: Diabetic foot ulcer (DFU) is one of the major chronic complications of diabetes mellitus and a leading cause of disability and death. The aim of this study was to identify immune-related therapeutic targets and drugs for DFU.
Methods: Two Gene Expression Omnibus datasets (GSE68183 and GSE80178) were merged, and differentially expressed genes (DEGs) were identified. Immune-related genes (IRGs) were extracted from the Immport database. Then the differentially expressed IRGs (DE-IRGs) were screened. Based on the DE-IRGs, protein-protein interaction network was constructed and hub genes were identified via Cytoscape software. An external dataset GSE134431 was used to verify the expression and diagnostic value of the hub genes. Potential compounds targeting key hub proteins, including C-X-C motif chemokine ligand 8 (CXCL8) and Janus kinase 2 (JAK2), were explored using the HIT2.0 platform and HERB database, and the binding activity between them was verified using molecular docking. Human immortalized keratinocytes (HaCaT cells) induced by high glucose (HG) were used to construct the DFU model in vitro, and cell proliferation, apoptosis and migration were detected by CCK-8, flow cytometry and Transwell assay after apigenin (API) treatment. Reverse transcriptional quantitative polymerase chain reaction and Western blot were used to detect the expression of key hub genes.
Results: CXCL8, and JAK2 were identified as hub genes in the pathogenesis of DFU. API, curcumin, quercetin, resveratrol and simvastatin had good binding activity with CXCL8 and JAK2 proteins. Treatment with Apigenin could reverse HG-induced inhibition of HaCaT cell viability and migration, and reduce cell apoptosis. After HaCaT cells were induced by HG, CXCL8 mRNA was significantly up-regulated in DFU, while JAK2 mRNA was significantly down-regulated. API treatment inhibited the expression of CXCL8 and increased the expression of JAK2, p-PI3K, p-AKT and p-mTOR in HG-induced HaCaT cells.
Conclusion: CXCL8 and JAK2 may be potential therapeutic targets for DFU. API can reduce HG-induced HaCaT cell injury and is expected to be a potential compound for DFU treatment.
Marine Fish Production in Odisha: A Comparative Analysis of ARIMA and Holt's Linear Trend Models for Forecasting and Production Instability
Authors: Mukherjee Samiran , Qureshi Neha Wajahat 
Published: January 2025

Abstract

The marine fish production sector of Odisha plays a significant role in the India's fisheries sector, accounting for 4.80% of the nation's marine fish output in 2022–2023. This study aims to investigate the trends, growth patterns, and instability of marine fish production in Odisha from 1990-91 to 2022-23 and forecast production for upcoming years. The annual time series data of marine fish production of Odisha was obtained. Marine fish production exhibited a gradual increase, but the overall CGR remained modest (1.56%). Exponential Trend method was used to fit the historical production data (R2 = 0.56). While ARIMA (0,1,0) and HLT models both were suitable for forecasting, HLT model achieved higher accuracy (93%). The study investigates district-wise growth patterns and instabilities, identifying Kendrapara as exhibiting significant instability in recent years. The analysis highlights the disparities in production, with Balasore, Jagatsinghpur, and Puri emerging as major contributors. Instability analysis using Coefficient of Variation (C.V.), Coppock’s Instability Index (CII), Cuddy-Delle Valle Index (CDVI) revealed Kendrapara’s instability in marine fish production. Kendrapara stands out for its notable instability, attributed to a combination of environmental, socio-economic, and government regulation-related factors such as cyclones, limited infrastructures, and fishing restrictions. Challenges such as underreporting and market constraints pose significant barriers to harnessing the potential of marine fisheries in Odisha. The study highlights need for improved production strategies in Odisha’s marine fisheries sector and places emphasis on determining the factors affecting state's marine fish landings ensuring sustainable growth and helping shape state and district-wise policy decisions on infrastructure development.
Short-Term Solar Irradiance and Power Forecasting in Uncertain Photovoltaic Systems
Authors: Marweni Manel , Hajji Mansour , Mansouri Majdi , Mimouni Mohamed Faouzi 
Published: January 2025

Abstract

Renewable energy (RE), while essential for the energy transition, poses significant challenges due to its variability and reliance on environmental factors , such as sunlight availability for Grid-Connected Photovoltaic (GCPV) systems. This intermittent nature complicates maintaining a stable balance between energy production and demand. To address these challenges, Energy Management (EM) plays a vital role in enabling optimal planning and resource allocation. In this context, forecasting becomes crucial for predicting production fluctuations and supporting proactive decision-making. Short-term forecasting, in particular, facilitates quick anticipation of variations and real-time adaptation of management strategies.
This study proposes a Feedforward Neural Network (FFNN) model for short-term forecasting in renewable energy systems, effectively addressing variability challenges. By incorporating prediction intervals, the model ensures accurate predictions with quantified uncertainty. The model demonstrates high performance, with irradiance Mean Absolute Error (MAE) ranging between 0.3115 and 0.3506, Root Mean Squared Error (RMSE) between 0.4061 and 0.4802, and R 2 of 1.00. For power, the MAE ranges from 7.0136 to 7.8298, RMSE from 8.2715 to 9.2084, and R 2 of 0.99, underscoring its reliability for energy management applications.
CO2 Reduction with High Bulk Turnover Numbers at Small Overpotentials by a fac-Mn(bpy)(CO)3L Complex with a Redox-Active, Electron Reservoir Ligand
Authors: Galvez-Rodriguez Andy , Martinez-Perez Octavio , Bergens Steven H. 
Published: January 2025

Abstract

The electrocatalytic CO2 reduction reaction (CRR) is required to convert CO2 into useful commodity chemicals with renewable energy thereby reducing global greenhouse gas emissions. We report significantly enhanced CRR activity by incorporating the s-donating, e- reservoir ligand Imdye (1-imidazole-2,4,6-tri(carbazol-9-yl)-3,5-dicyanobenzene) within the complex fac-[MnI(bpy)(CO)3(Imdye)]+ (bpy = 2,2'-bipyridine). The reduction potentials of Imdye, MnI/0, and CO2 to CO are close, allowing the active catalyst [Mn0(bpy)(CO)2(Imdye-)]- to provide 2e- to CO2 at small overpotentials. This system reduces CO2 to CO with bulk turnover numbers up to 830 very near the CRR reduction potential. This CRR activity arose from Imdye promoting the CRR at small overpotentials, and from utilizing the electrooxidation of CH3OH/H2O to CO2, 6H+ and 6e- at the Pt counter electrode, neutralizing pH changes from the CRR. These strategies will apply to most CRR electrocatalytic systems.
COVID-19 Transmission During the Winter 2023-24 Surge: A Comparative Analysis of Surveillance Estimates in the U.S., Canada, and the U.K.
Authors: Hoerger Michael , Gerhart James I. , Peyser Tristen , Pyke Nicole , Garg Nicole , Hall Carly J. , Swartz Maria C. , Swartz Michael D. , Willette Sara Anne , Baker Courtney N. , Eastman Joseph L. 
Published: January 2025

Abstract

Background: Better estimates of COVID-19 transmission are needed since testing has declined. The present investigation examined the correspondence among estimates of COVID-19 transmission during the winter 2023-24 surge using wastewater-derived estimates for the U.S. and Canada and testing-derived estimate in the U.K. to evaluate validity and provide vital public health data on transmission levels.
Methods: The study used data from wastewater-derived estimates of COVID-19 transmission in the U.S. (Pandemic Mitigation Collaborative dashboard) and Canada (COVID-19 Resources Canada dashboard) and testing-based surveillance in the U.K. (Health Security Agency). Data sets were linked by date and relative to the peak transmission date within each data set. Analyses focused on the UKHSA study period of November 2023 to March 2024. Analyses 1) described transmission on the peak day, 2) examined relative agreement in the patterns of transmission via correlations, 3) examined absolute agreement on the proportion of the population actively infectious across the two months of peak transmission, and 4) described estimates of the proportion of populations infected during the peak two months.
Results: On the peak day of infections, an estimated 1.95 million people were infected in the U.S., 148 thousand in Canada, and 431 thousand in the U.K., meaning an estimated 2.5%-4.5% of these populations were actively infectious. Estimates showed high relative agreement in the patterns of transmission throughout the wave, especially between the U.S. and U.K. (r=.974, p<.001). During the wave, 93.5% of U.S. estimates and 68.8% of Canada estimates had excellent or better agreement with the U.K. data. An estimated >100 million people were infected in the U.S., Canada, and the U.K. during the two peak months, or 20.9%-26.0% of each population.
Discussion: Findings support the ongoing public health significance of COVID-19 by documenting high levels of transmission during the winter 2023-24 surge. Transmission estimates had high agreement across methodologies and nations. More resources are needed to prevent transmission and diagnose and treat long-term health sequelae.
Differential growth, Cardiovascular risk, and Polymorphism in Targeted Regions of Ryanodine Receptor 2 (RYR2) gene in Three Breeds of Chickens.
Authors: Faisal Olayiwola Kolawole , K Sulaiman Mariam , A.A Professor Toye 
Published: January 2025

Abstract

Sudden death syndrome (SDS) is a stress-related genetic disease in broilers with no diagnostic clinical or necropsy finding. SDS is often preceded by elevated markers of cardiovascular risks (Obesity, Blood glucose, Lipidemia and Inflammation) in broilers. Mutation of Ryanodine Receptor 2 (RYR2) gene, which controls rapid release of ca2+ from the sarcoplasmic reticulum (SR) into the Cystol during muscle contraction has been associated with sudden death syndrome in broilers, but there are no reports on the genetic association between RYR2 mutation and cardiovascular risk markers in broiler. This study aims to investigate the role of RYR2 mutation in the development of SDS using the linkage association approach. The study compares exotic broiler chicken (Ross 308, Arbor Acres) with the less susceptible indigenous Noiler chicken breed as a contrast to identifying genetic markers linked to SDS susceptibility. Key findings revealed a Single Nucleotide Polymorphism (SNP) near a functional RYR2 region at chicken genome location 3:36968262. The Noiler and Arbor Acres breeds carried an A (Adenosine) allele, while Ross 308 carried a G (Guanine) allele, with the G allele associated with increased cardiovascular risk and stress. Moreover, Arbor Acres and Ross 308 breeds exhibited higher stress levels and cardiovascular risk than the Noiler breed using certain metrics of measurement. These results underscore the critical role of RYR2 genetic differences in growth and cardiovascular traits in poultry, these findings suggest that genetic differences in the RYR2 gene play a crucial role in growth and cardiovascular traits in poultry, offering valuable insights for breeding programs.
Gravity Model applied in External Trade Betwen Portugal and Comonwealth
Authors: Sandambi Nerhum 
Published: January 2025

Abstract

The study analyses foreign trade between Portugal and Commonwealth countries in the period 1990-2017. The main objective is to analyse foreign trade between Portugal and the Commonwealth countries and to understand the main factors that influence the volume of foreign trade. The study was estimated using a gravity model, but the model was static, using Ordinary Least Squares (OLS), Fixed Effects (FE) and Random Effects (RE) models. The main results show that economic distance measured by real GDP between the countries of origin and destination has a positive impact of 2.145% on the volume of foreign trade, income levels in the countries of destination have a positive impact on the volume of foreign trade of 1.238%, although it is significant at the 1% level, the exchange rate has a negative impact on trade and is not relevant in explaining trade levels. Physical distance has a positive impact, but is not significant in explaining the volume of foreign trade between Portugal and the Commonwealth countries.
Jel Classification: F00; F1; F14.
АДМИНИСТРАТИВНАЯ СИСТЕМА ЦЕНТРАЛЬНЫХ РАЙОНОВ НОВГОРОДСКОЙ ЗЕМЛИ В X – НАЧАЛЕ XVII ВЕКА В КОНТЕКСТЕ ИСТОРИИ ТЕРРИТОРИАЛЬНЫХ ЮРИСДИКЦИЙ
Authors: ФРОЛОВ А.А. 
Published: January 2025

Статья посвящена общей характеристике административной системы, существовавшей в эпоху Рюриковичей на Новгородской земле, в двух аспектах: территориальный рост Новгородской земли и формы управления на подконтрольных территориях в X начале XVII в. Развивая достигнутое в историографии понимание проблемы, автор рассматривает историю административной системы новгородских земель в контексте истории территориальных юрисдикций различных типов. Важнейшим элементом этой системы было сместное управление на землях, расположенных на границе Новгорода с Великим княжеством Владимирским и смоленскими землями, где новгородцам принадлежала лишь часть прерогатив. Помимо систематизации знаний, полученных в ходе полуторавекового изучения проблемы, работа предлагает во многом новые интерпретации сведений важнейших исторических источников: Устава князя Святослава 1137г., Устава князя Ярослава о мостех , писцовых книг рубежа XVXVIвв.
The article is devoted to the general characteristic of the administrative system of Novgorod land in the 10th beginning of the 17th century in two aspects: 1)the territorial growth of Novgorod land and 2)forms of governance in the territories under Novgorod control. The history of the Novgorod administrative system is examined in the context of the history of the territorial jurisdictions of various types. The most important element of this system was the so called joint management. This mode was practiced in lands along the border between Novgorod and the Grand Duchy of Vladimir and between Novgorod and Smolensk. Only part of the prerogative belonged to Novgorod, as the administrative power was shared with the neighboring lands listed above. In addition to systematizing the historiographical data made available since the middle of the 19th century, the article offers some new interpretations of such important historical documents as the Charter of Prince Svyatoslav of 1137, the Charter of Prince Yaroslav o mostekh, and cadastres from the turn of the 15th 16th centuries.
МЕТАГЕОГРАФИЧЕСКИЕ ОСИ ЕВРАЗИИ
Authors: ЗАМЯТИН Д.Н. 
Published: January 2025

Статья представляет собой введение в проблематику метагеографии особой междисциплинарной области знания, находящейся на стыке науки, философии и искусства (в широком смысле) и изучающей различные возможности, условия, способы и дискурсы географического мышления и воображения. Автор дает обширный экскурс в разработку рационалистических и сциентистских подходов к этому понятию, начиная с первой половины XIX в. Особое внимание автора привлекают проблемы формирования географического образа Евразии как мирового острова , или острова-материка , фрактальность пространства Евразии. Предлагаемая автором дискурсивная схема осевой метагеографической сборки Евразии несомненно предполагает содержательные историко-географические, геополитические, геокультурные и геоэкономические импликации.
The article represents an introduction to meta-geographical problems. Meta-geography is a specific knowledge field at the junction of science, philosophy and art it studies different aspects and discourses of geographical thinking and imagination. The author provides a broad overview of rationalistic and scientistic approaches to this concept starting from the first half of the 19th century. The problems of the geographical image of Eurasia as a world island and of the fractality of Eurasias space are considered. The author suggests a discursive schema for the meta-geographical axial composition of Eurasia which assumes substantial historico-geographical, geopolitical, geo-cultural, and geo-economic implications.
ИСТОРИКО-ГЕОГРАФИЧЕСКИЙ ОБРАЗ СТАВРОПОЛЯ: ОТ ГОРОДА-КРЕПОСТИ ДО СТОЛИЦЫ ЖИТНИЦЫ И ЗДРАВНИЦЫ
Authors: ЧИХИЧИН В.В. 
Published: January 2025

Историко-географические образы территорий содержат не только современные представления, связанные с историей этих территорий, а отражают динамику представлений населения о городах и регионах с момента вхождения в сознание населения до настоящего времени. Трансформация образа Ставрополя проходила в четыре этапа под влиянием как внешних, так и внутренних факторов. Критериями для выделения этапов послужили административные преобразования, важные исторические события, изменение особенностей самого города. Первый этап вхождение образа Ставрополя в общественное сознание населения России (17771847), второй этап закрепление образа Ставрополя в общественном сознании населения России (18471917), третий этап Изменение образа Ставрополя в советское время (19171991), четвертый этап трансформация образа Ставрополя в постсоветское время (с 1991 г.).
Historical and geographical images of the territories contain not only modern representations, connected with the history of these territories, but also reflect past dynamics of constantly evolving representations by the population about the cities and regions. The image of Stavropol transformed in four stages due to both external and internal influences. These stages were determined by administrative changes, the evolution of features of the city, and important historical events. During the first stage the image of Stavropol entered Russian public consciousness (17771847) in the second stage this image became fixed in public consciousness (18471917) the third stage marked the evolution of the citys image during Soviet times (19171991), and the fourth stage its transformation in the post-Soviet period (from 1991).
ПРОБЛЕМА ГЕОПРОСТРАНСТВЕННЫХ КОНСТРУКТОВ В СОВРЕМЕННОМ ПУБЛИЧНОМ И АКАДЕМИЧЕСКОМ ДИСКУРСЕ ЭСТОНИИ
Authors: УЛУНЯН А.А. 
Published: January 2025

С момента восстановления независимости Эстонии в 1991г. усилились дискуссии в общественных и академических кругах по вопросу геопространственного ориентирования нового государства. Главный вопрос всех обсуждений заключался том, как и когда Эстония может добиться того, чтобы обеспечить себе наиболее выгодное и безопасное место в международном сообществе и создать свою собственную новую политическую географию . Общественный и академический дискурсы развивались с учётом геопространственных планов, которые существовали в эстонской политической и академической мысли в 20-е 30-е гг. ХХ в., исторических традиций и общемирового процесса появления новых регионов .
Since Estonia re-established its independence in 1991, public and academic discussions of the newly born states geospatial orientation has intensified. The central question of these deliberations involved the manner and time in which Estonia could achieve a useful and secure place within the international community and build up her own new political geography. Public and academic discourse developed with reference to geospatial plans which had existed in Estonian political and academic thought in the 192030s, historical traditions and the global process of the emergence of new regions.
ИСТОРИЧЕСКАЯ ГЕОГРАФИЯ У МЕДИЕВИСТОВ МГУ
Authors: ГУСАРОВА Т.П. 
Published: January 2025

В статье рассмотрен многолетний опыт преподавания исторической географии на кафедре истории Средних веков и раннего Нового времени исторического факультета МГУ им. М.В. Ломоносова. Практикуемый на кафедре комплексный подход к изучению исторической географии сочетает освоение общего курса с практическими занятиями, включает в себя элемент самостоятельной исследовательской работы студента, систематическое повторение историко-географической номенклатуры. Такой метод дает положительные результаты, помогая, наряду с другими специальными дисциплинами (историографией, источниковедением ит.д.) готовить и профессионального медиевиста, и специалиста более широкого профиля.
The paper addresses the development of training in historical geography at the Department of Medieval and Early Modern History at Moscow State Lomonosov University. The Departments comprehensive approach combines a general course, practical studies, elements of individual student research, and the systematic repetition of the historico-geographical nomenclature. This approach yields positive results. Together with other disciplines (historiography, source studies, etc.) it helps to train professional medievalists and general historians.
Utilizing Plant Phytoconstituents in Metal Oxide Nanoparticle Synthesis for Cancer Therapies
Authors: Dubey Swati , Virmani Tarun , Yadav Shiv Kumar , Kumar Girish , Sharma Ashwani , Gugulothu Dalapathi 
Published: January 2025

Background:
The metal oxide nanoparticles possess unique properties such as biological compatibility,
superior reactivity, and capacity to develop reactive oxygen species, due to this they have drawn significant
interest in cancer treatment. The various MONPs such as cerium oxide, Copper oxide, Iron oxide, Titanium
dioxide, and Zinc oxide have been investigated for several types of cancers including brain, breast, cervical,
colon, leukemia, liver, lung, melanoma, ovarian, and prostate cancers. However, traditional physiochemical
synthetic methods for MONPs commonly include toxic materials, a major concern that raises questions regarding
their biocompatibility and safety.

Objective:
This study aims to investigate the role of plant phytoconstituents in the development of MONPs via
green synthesis and explore the therapeutic effectiveness of MONPs in treating several types of cancer. Primarily,
it examines the potential of plant phytoconstituents (phenolic compounds, flavonoids, glycosides, alkaloids,
etc.) in the development of MONPs as well as their improved ability to target numerous types of cancer.

Methods:
A systemic search was conducted on recent literature, focusing on developing green MONPs by utilizing
plants' phytoconstituents (plant extracts). The study of plant phytochemicals (present in different parts of
a plant such as leaves, flowers, stems, peels, and roots) and their role in the synthesis of green metal oxide
nanoparticles as well as their anticancer activity against several types of cancers was analyzed. Also focusing
on their anticancer mechanism that involves ROS production, generates oxidative stress, and apoptosis leads
to cancer inhibition.

Results:
Phytochemicals-mediated metal oxide nanoparticle synthesis revealed many advantages such as improved
biological compatibility and enhanced sensitivity towards cancer cells. Phytochemicals present in plant
extracts act as natural capping, reducing, and stabilizing agents, enhancing nanoparticle synthesis which leads
to synergistic anticancer activity. Additionally, the natural antioxidant and anticancer activity of various phytochemicals
enhances the therapeutic potential of metal oxide nanoparticles, producing them more effective
against ROS-generated apoptosis and showing negligible toxicity towards normal cells.

Conclusion:
The utilization of plant phytochemicals in metal oxide nanoparticle production presents a safe,
eco-friendly, sustainable, and effective approach to developing effective and safer cancer nanomedicines.
Green synthesis not only increases anticancer activity but also decreases the biocompatibility problems associated
with the physiochemical synthetic approach. Further research needs to concentrate on improving this synergy
to create a targeted phytochemical-based metal oxide nanoparticle for cancer therapeutics.