bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antipsychotic drugs and their effects on cognitive function: protocol for a systematic review, pairwise, and network meta-analysis
Authors: Feber Lena , Peter Natalie , Schneider-Thoma Johannes , Siafis Spyridon , Bighelli Irene , Hansen Wulf-Peter , Prates Baldez Daniel , Salanti Georgia , Keefe Richard S. E. , Engel Rolf R. , Leucht Stefan 
Published: March 2023

Abstract
Background
There is evidence that antipsychotic drugs differ in their effect on the cognitive symptoms of schizophrenia. So far, there is no comprehensive systematic review available that would enable providers and patients to make informed choices regarding this important aspect of treatment. With a large number of substances available, conventional pairwise meta-analyses will not be sufficient to inform this choice. To fill this gap, we will conduct a network meta-analysis (NMA), integrating direct and indirect comparisons from randomized controlled trials (RCTs) to rank antipsychotics according to their effect on cognitive functioning.

Methods
In our NMA, we will include RCTs in patients with schizophrenia or schizophrenia-like psychoses comparing one antipsychotic agent with another antipsychotic agent or placebo that measures cognitive function. We will include studies on patients of every age group, in any phase of illness (e.g., acute or stable, first episode or chronic schizophrenia, in- or outpatients) with an intervention time of at least 3 weeks. The primary outcome will be the composite score of cognitive functioning, preferentially measured with the test battery developed by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. The secondary outcomes include the seven cognitive domains that the composite score is composed of, as well as functioning and quality of life. Study selection and data extraction will be conducted by at least two independent reviewers. We will use the Cochrane Risk of Bias tool 2 to determine the risk of bias in studies, and we will evaluate the confidence in the results using Confidence in Network Meta-Analysis (CINeMA). We will perform NMA using R (package netmeta). We will conduct subgroup and sensitivity analyses to explore the heterogeneity and assess the robustness of our findings.

Discussion
This systematic review and network meta-analysis aims to inform evidence-based antipsychotic treatment choice for cognitive deficits in schizophrenia patients by analyzing existing RCTs on this subject. The results have the potential to support patients’ and physicians’ decision-making processes based on the latest available evidence.

Systematic review registration
PROSPERO CRD42022312483
A half-discrete Hilbert-type inequality in the whole plane with the constant factor related to a cotangent function
Authors: You Minghui 
Published: March 2023

AbstractIn this work, by the introduction of some parameters, a new half-discrete kernel function in the whole plane is defined, which involves both the homogeneous and the nonhomogeneous cases. By employing some techniques of real analysis, especially the method of a weight function, a new half-discrete Hilbert-type inequality with the new kernel function, as well as its equivalent Hardy-type inequalities are established. Moreover, it is proved that the constant factors of the newly obtained inequalities are the best possible. Finally, assigning special values to the parameters, some new half-discrete Hilbert-type inequalities with special kernels are presented at the end of the paper.
On Toeplitz operators between different Fock–Sobolev-type spaces
Authors: Chen Jianjun , Xu Guangxia 
Published: March 2023

AbstractIn this paper, we characterize those positive Borel measurable symbols μ on $\mathbb{C}^{n}$

C
n

that induce the Toeplitz operators $T^{\alpha}_{\mu}$

T
μ
α

to be bounded or compact between different Fock–Sobolev–type spaces $F^{p}_{\alpha}$

F
α
p

and $F^{\infty}_{\alpha}$

F
α
∞

with $0< p\leq \infty $
0
<
p
≤
∞
.
Effect of complex hydraulic variables and physicochemical factors on freshwater mussel density in the largest floodplain lake, China
Authors: Jia Chenchen , Wu Chenhuizi , Huang Xiaochen , Zhou Chunhua , Ouyang Shan , Liu Xiongjun , Wu Xiaoping 
Published: March 2023

Abstract
Background
Habitat degradation and flow regime alterations are two of the most prominent and common impact factors to freshwater mussel populations. Knowledge of the correlation between freshwater mussel distribution, density and habitat characteristics is important for maintaining and restoring their biodiversity and ecological functions. Information on predicting habitat suitability of freshwater mussels is lacking in China. Here, we aimed to analyze the correlation between freshwater mussel density and complex hydraulic and physicochemical variables to predict habitat suitability.

Results
The results showed that four complex hydraulic variables (boundary Reynolds number, critical shear stress, bed roughness and mean sediment particle size) and four physicochemical variables (water temperature, chlorophyll-a, transparency and pH) were key factors for predicting habitat suitability of freshwater mussels. Freshwater mussel density was significantly correlated with Froude number, water temperature and chlorophyll-a.

Conclusions
Our results confirmed that higher freshwater mussel density would be associated with areas that are stable in complex hydraulic and physicochemical variables. These results provide an important insight into the conservation of freshwater mussel diversity and their habitat restoration in China and globally.
Development of analytical method for veterinary antibiotics and monitoring of residuals in agricultural environment
Authors: Kim Jin-Wook , Hong Young-Kyu , Ryu Song-Hee , Kwon Oh-Kyung , Lee Yong-Bok , Kim Sung Chul 
Published: March 2023

AbstractVeterinary antibiotics (VAs) administered to livestock are introduced into the soil through livestock manure and compost. These antibiotics can run off to surface water or leach into groundwater during rainfall, causing problems such as antibiotic contamination or the occurrence of antibiotic-resistant bacteria. In this study, an analytical method for detecting four classes of VAs (penicillin, tetracyclines, macrolides, and sulfonamides) in river water and soil was developed, and the occurrence of residual antibiotics in the agricultural environment was monitored. Soil samples were extracted with the McIlvain buffer solution and pretreatment was conducted using solid-phase extraction, followed by liquid chromatography-tandem mass spectrometry to quantify target VAs. The results of this study showed that the recovery ranged from 62 to 121% in river water and 40.2–149.3% in soil. Among the other VAs, amoxicillin and spiramycin were observed to have low recoveries in all the samples. The method detection limit (MDL) was calculated in the range of 2.1–12.3 ng L−1 in river water and 1.2–13.2 ng kg−1 in soil, and the limit of quantification was 6.6–39.2 ng L−1 and 4.0–42.0 ng kg−1, respectively. This optimal method was then applied to measure the residual concentrations of VAs in river water, sediment, and soil samples around the Muhan watershed in Korea. A total of seven antibiotics were detected, and their concentrations ranged from 0.014 to 0.309 μg L−1in river water, and 1.45–9.04 μg kg−1 in sediment and arable soil. This method can be used to screen VAs in river water and soil and is expected to be used as primary data for examining the occurrence and fate of antibiotics in agricultural environments.
Mechanisms of Lactation-induced Infertility in Female Mice
Authors: Hackwell Eleni C R , Ladyman Sharon R , Brown Rosemary S E , Grattan David R 
Published: March 2023

Abstract
Lactation in mammals is associated with a period of infertility, which serves to direct maternal metabolic resources toward caring for the newborn offspring rather than supporting another pregnancy. This lactational infertility is characterized by reduced pulsatile luteinizing hormone (LH) secretion and lack of ovulation. The mechanisms mediating suppression of LH secretion during lactation are unclear. There are potential roles for both hormonal cues such as prolactin and progesterone, and pup-derived cues such as suckling, on the inhibition of reproduction. To enable future studies using transgenic animals to investigate these mechanisms, in the present study our aim was to characterize lactational infertility in mice, and to investigate the effect of removing pup-derived cues on LH secretion, time to ovulation, and kisspeptin immunoreactivity. We first confirmed that C57BL/6J mice experience prolonged anestrus during lactation, which is dependent on establishment of lactation, as removal of pups the day of parturition led to immediate resumption of pulsatile LH secretion and normal estrous cycles. Once lactation is established, however, the lactational anestrus persisted for several days even after premature removal of pups. Pharmacological suppression of prolactin following premature weaning significantly reduced this period of lactational infertility. Progesterone does not appear to play a significant role in the suppression of fertility during lactation in mice, as levels measured during lactation were not different from nonpregnant mice. These data suggest that prolactin plays a key role in mediating anestrus during early lactation in mice, even in the absence of the suckling stimulus.
The alpha7 integrin subunit in astrocytes promotes endothelial blood–brain barrier integrity
Authors: Chen Zhihua , Kelly Jack R. , Morales John E. , Sun Raymond C. , De Arpan , Burkin Dean J. , McCarty Joseph H. 
Published: March 2023

ABSTRACT
The blood–brain barrier (BBB) is a vascular endothelial cell boundary that partitions the circulation from the central nervous system to promote normal brain health. We have a limited understanding of how the BBB is formed during development and maintained in adulthood. We used quantitative transcriptional profiling to investigate whether specific adhesion molecules are involved in BBB functions, with an emphasis on understanding how astrocytes interact with endothelial cells. Our results reveal a striking enrichment of multiple genes encoding laminin subunits as well as the laminin receptor gene Itga7, which encodes the alpha7 integrin subunit, in astrocytes. Genetic ablation of Itga7 in mice led to aberrant BBB permeability and progressive neurological pathologies. Itga7−/− mice also showed a reduction in laminin protein expression in parenchymal basement membranes. Blood vessels in the Itga7−/− brain showed separation from surrounding astrocytes and had reduced expression of the tight junction proteins claudin 5 and ZO-1. We propose that the alpha7 integrin subunit in astrocytes via adhesion to laminins promotes endothelial cell junction integrity, all of which is required to properly form and maintain a functional BBB.
The role of mitochondrial dynamics in mtDNA maintenance
Authors: Sabouny Rasha , Shutt Timothy E. 
Published: March 2023

ABSTRACT
The dynamic nature of mitochondria, which can fuse, divide and move throughout the cell, allows these critical organelles to adapt their function in response to cellular demands, and is also important for regulating mitochondrial DNA (mtDNA). While it is established that impairments in mitochondrial fusion and fission impact the mitochondrial genome and can lead to mtDNA depletion, abnormal nucleoid organization or accumulation of deletions, it is not entirely clear how or why remodeling mitochondrial network morphology affects mtDNA. Here, we focus on recent advances in our understanding of how mitochondrial dynamics contribute to the regulation of mtDNA and discuss links to human disease.
Changes in pancreatic exocrine function, fat and fibrosis in diabetes mellitus: analysis using MR imaging
Authors: Yasokawa Kazuya , Kanki Akihiko , Nakamura Hiroki , Sotozono Hidemitsu , Ueda Yu , Maeba Kiyoka , Kido Ayumu , Higaki Atsushi , Hayashida Minoru , Yamamoto Akira , Tamada Tsutomu 
Published: March 2023

Objective
To evaluate the relationships between hemoglobin A1c (HbA1c) levels with exocrine pancreatic function using cine-dynamic magnetic resonance cholangiopancreatography (MRCP) and the pancreatic parenchyma using fat-suppressed T1 mapping and the proton density fat fraction (PDFF).

Methods
Patients who underwent 3T-MRI and HbA1c measurement were retrospectively recruited. MRI included cine-dynamic MRCP with a spatially selective inversion-recovery (SS-IR) pulse, fat-suppressed Look-Locker T1 mapping and multiecho 3D Dixon-based PDFF mapping. The pancreatic exocrine secretion grade on cine-dynamic MRCP, T1 values, and PDFF were analyzed in non-diabetic (n = 32), pre-diabetic (n = 44) and diabetic (n = 23) groups defined using HbA1c.

Results
PDFF was weakly correlation with HbA1c (ρ = 0.30, p = 0.002). No correlations were detected between HbA1c and secretion grade (ρ = - 0.16, p = 0.118) or pancreatic parenchymal T1 (ρ = 0.13, p = 0.19). The secretion grade was comparable between the three groups. The T1 value was higher in diabetic (T1 = 1006.2+/- 224.8 ms) than in non-diabetic (T1 = 896.2+/- 86.3 ms, p = 0.010) and pre-diabetic (T1 = 870.1+/- 91.7 ms, p &lt; 0.010) patients. The PDFF was higher in diabetic (FF = 11.8+/- 8.7 %) than in non-diabetic (FF = 6.8+/- 4.2 %, p = 0.014) patients.

Conclusion
Pancreatic exocrine function, T1, and FF showed no correlation with HbA1c. Pancreatic T1 and fat fraction is increased in patients with Type 2 diabetes mellitus.

Advances in knowledge
This study demonstrates unaffected exocrine function in pre-diabetes and diabetes and confirms that pancreatic parenchymal T1 and FF are increased in patients with diabetes.
Efektifitas Penyuluhan tentang Adaptasi Kebiasaan Baru sebagai Upaya Pencegahan Covid-19
Authors: Pratiwi Mayditania Intan Bunga , Zahrotun Nisak , Syntia Veronica Rozana 
Published: March 2023

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. Efforts to increase public knowledge regarding the importance of a clean and healthy lifestyle to change people's attitudes and behavior. Community service was carried out at TPQ Al-Masyhud for two weeks in August 2020. This study aims to determine changes in knowledge, behavior, and attitudes of students at TPQ Al-Masyhud before and after being given the socialization and education of the New Normal. The educational media used were posters, videos, and booklets. The method used is a quasi-experimental method, with a pre-test post-test one-group design without a control group which was carried out twice, pre-test and after education (post-test). Education was given to 25 children through blended learning, using the WhatsApp application, and limited face-to-face meetings with 5 children. Based on the evaluation results of educational activities, the new habit adaptation protocol significantly impacted aspects of knowledge, attitudes, and behavior of TPQ Al-Masyhud students. This is evidenced by the statistical results on the post-test knowledge p = 0.001, behavior p = 0.001, and attitude p = 0.001. Participants are able to understand the causes, symptoms and be able to apply COVID-19 prevention methods in daily life, how to use a good and proper mask, how to wash hands, and ethical ways when coughing.
A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus
Authors: Inthawong Manutsanun , Pinthong Nattapon , Thaiprakhong Areerat , Wangrangsimakul Tri , Sunyakumthorn Piyanate , Hill Jennifer , Sonthayanon Piengchan , Paris Daniel H. , Dunachie Susanna J. , Kronsteiner Barbara 
Published: March 2023

Background
Assessment of cellular immune responses by combining intracellular cytokine staining and immunophenotyping using flow cytometry enables the simultaneous measurement of T cell phenotype and effector function in response to pathogens and vaccines. The use of whole blood samples rather than peripheral blood mononuclear cells avoids both the need for immediate processing and loss of functional antigen presenting cells due to processing and cryopreservation. Using whole blood provides the possibility to stimulate peripheral T cells in situ, and is more suitable for studies where sample volume is limited, such as those involving children, the elderly and critically ill patients. The aim of this study was to provide a robust tool for the assessment of antigen-specific T cell responses in a field site setting with limited resources.

Methodology/principle findings
We optimised a flow cytometry-based whole blood intracellular cytokine assay (WBA) with respect to duration of antigen stimulation and intracellular protein retention time. We demonstrate the ability of the WBA to capture polyfunctional T cell responses in the context of acute scrub typhus infection, by measuring IFN-γ, TNF and IL-2 in CD4+ and CD8+ T cells in response to the causative agent O. tsutsugamushi (OT). Using an optimised OT antigen preparation, we demonstrate the presence of polyfunctional antigen-specific memory CD4+ T cells in the blood of scrub typhus patients.

Conclusions/significance
In conclusion, this flow cytometry-based WBA is well-suited for use at field study sites, and enables the assessment of polyfunctional T cell responses to infectious agents and vaccines through delineation of antigen-specific cytokine secretion at the single cell level.
Analysis of disease burden due to high body mass index in childhood asthma in China and the USA based on the Global Burden of Disease Study 2019
Authors: Zhang Chengyue , Qu Qing , Pan Kaiyu 
Published: March 2023

Background
Currently, there is a growing concern about the disease burden of child asthma particularly due to high body mass index (BMI). The prevalence and disease burden of asthma differ between developing and developed countries, with implications on disease intervention. Therefore, we provide a comparative analysis of childhood asthma between China and the United States of America (USA).

Methods
Using the Global Burden of Disease (GBD) 2019 data, we estimated and compared the age-standardized prevalence, disability-adjusted life years (DALYs), years of life lost (YLLs), years of lost due to disability (YLDs), DALYs due to high BMI of asthma in children aged 1–14 years in China and the USA. Joinpoint regression analysis was applied to assess changes in temporal trends.

Results
DALYs due to high BMI and the ratio of DALYs to DALYs due to high BMI in children with asthma showed a significant upward trend in both countries and were higher in males than in females. Almost all epidemiological indicators of asthma showed a hump of curve from 2014 to 2019, and peaked in 2017. There was a decreasing trend of YLLs for asthma in children both countries, while China has a saliently greater decreasing trend.

Conclusion
The disease burden caused by high BMI of childhood asthma was on the rise in children with asthma in both China and the USA. High BMI needs to be taken more into account in the development of future policies for the prevention, control, and treatment of childhood asthma. However, the increasing trend of this disease burden in American children was significantly lower than that in Chinese children. We recommend learning from the American government to impose a high-calorie tax, increase physical exercise facilities, and provide better health care policies.
The Rhetoric of Physical Violence
Authors: Childers Jay P. 
Published: March 2023

Abstract
This essay serves as the introductory essay for this special issue on “The Rhetoric of Violence.” In conversation with the six other essays in this special issue, I suggest that scholars in our field need to focus more explicitly on the rhetorical purposes of physical violence. To support that suggestion, I offer a working definition of how we might conceptualize violence broadly and then distinguish physical violence from two others kinds that rhetorical scholars have been studying for years now—rhetorical violence and structural violence. Distinguishing that first mode of violence as worthy of more of our attention. I then argue that the primary purpose of most physical violence is to affectively and symbolically define and reinforce individual and group identities.
Plátano's Pharmacy: The Republic's Taste of its Own Medicine
Authors: Maldonado José Ángel 
Published: March 2023

Abstract
On January 6, 2021, supporters of Donald Trump stormed the US Capitol, demanding the head of Vice-President Mike Pence while challenging the results of a fair presidential election. Amid the shock, US journalists—finding few words to describe the severity of the moment—dusted off the old term: “banana republic.” Banana republics are countries whose economy depends on the export of a finite natural resource, like bananas. By design, the ruling elites of banana republics work alongside foreign, multinational corporations to benefit from the republic's human labor. Banana republics are typically governed by a military dictator appointed by a foreign power and elected through illegitimate elections. Notably, dictators ascend to power through military and/or populist violence, like coups d’état and magnicide. Among the reckonings that US Americans encountered the days following the riots was the idea that their country had been relegated beside those so-called “banana republics.” Indeed, the public display of violence brought about by a populist insurrection indicated a failure of the highest rank. In this essay, I ask: “What are the implications of treating violence seriously as a rhetorical event?” I suggest that referring to the United States as a “banana republic” due to populist violence against sacrosanct, democratic institutions requires that US Americans open themselves to the possibility of unexceptionalism, a recognition that—like a medicine—few are willing to stomach. I offer the idea that Donald Trump is the first Latin American president of the United States, and, in turn, that the United States has opened itself to a vulnerability whose damage is unknowable. To do so, I revisit two works by Jacques Derrida: Autoimmunity (2003), an interview where he describes the paradox of post-9/11 counterterrorist violence as autoimmunity, or, how organisms attack themselves in a quasi-suicidal fashion; and Plato's Pharmacy (1968), where he demonstrates an approach to unveiling the unseen ideological traces that haunt particular words. I ask: what is the unseen, terroristic force concealed by the claim that the United States is a banana republic? I explore the Capitol riots as a new “major event” (a televised moment playing on loop and accompanied by specific phrases), where a new type of terrorist uses state-sanctioned freedoms to inflict violence upon itself. I then draw from Chilean poets to provide scholars a lesson on the role of violence in the forming of national identity.