bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in the area of suitable breeding habitat for the Endangered Lake Titicaca Grebe Rollandia microptera, 2001–2020
Authors: Villar D. A. , Long P. R. , Gutierrez Tito E. R. , Moreno Terrazas E. G. , Gosler A. G. 
Published: March 2023

Summary
The Lake Titicaca Grebe Rollandia microptera is a poorly studied endemic species found in the Lake Titicaca watershed of Peru and Bolivia. Multiple surveys from the early 2000s indicated that the species was suffering a rapid population decline with an unknown cause. At the same time as these surveys, reports emerged that there was an increase in burning of the totora wetlands which are thought to be the primary habitat for the Lake Titicaca Grebe. However, since 2003, no work has been published either on the current population of the Lake Titicaca Grebe, or the extent of the totora wetlands in the Lake Titicaca region. This paper used satellite data to monitor the change in extent of habitat potentially suitable for the Lake Titicaca Grebe to determine whether habitat loss is likely to be a major driver of population declines in this species. We found that the extent of potentially suitable wetland remained stable between 2001 and 2020, though there are more local regional trends of change in extent of totora. We also found that multiple areas exist that might support Lake Titicaca Grebe populations, but where ornithological knowledge is lacking. We suggest no change to the IUCN status of the Lake Titicaca Grebe, but recommend that further fieldwork is required to monitor the species’ current population, especially in previously unstudied but potentially habitable areas.
Attitudes and perceived knowledge of health professionals on the food labelling reform in Israel
Authors: Furman-Assaf Sharon , Accos-Carmel Moran , Kolobov Tatyana , Blaychfeld-Magnazi Moran , Endevelt Ronit , Tamir Orly 
Published: March 2023

AbstractObjectives:To assess the attitudes and perceived knowledge of health professionals regarding the food product judgemental-labelling reform that began in January 2020 in Israel.Design:Cross-sectional survey.Settings:An online survey among health professionals working in the Israeli health system.Participants:456 participants (118 physicians, 207 nurses, 131 nutritionists).Results:Most respondents (89·9 %) were women, 36 % had over 20 years of professional experience. All nutritionists, 96·6 % of physicians and 94·7 % of nurses reported hearing about the reform, and most (88·9 % of nurses, 76·3 % of physicians and 75·6 % of nutritionists) claimed supporting the reform to a great or very great extent. Most respondents believe they should discuss issues related to healthy eating with their patients (91·8 % of nurses, 94·9 % of physicians and all nutritionists), but only about half (47·5 % of physicians and 57·0 % of nurses) reported that they have sufficient knowledge in this field, particularly about food labelling. Almost two-thirds of nutritionists (60·3 %) reported instructing patients to change their food intake according to labelling v. 40·1 % and 34·7 % of nurses and physicians, respectively. Only some respondents felt that they could influence their patients’ nutrition habits. Most participants believe that additional regulatory measures should also be used to promote healthy nutrition.Conclusions:There is a gap between the desire of physicians and nurses to provide nutritional guidance to the public and their actual knowledge about the labels’ meaning as well as their competencies in providing nutrition counselling. When formulating a reform, policymakers should provide clear guidelines about the expectations of implementing it in therapeutic practice.
Confronting Solid‐State Shear Bias: Magmatic Fabric Contribution to Crustal Seismic Anisotropy
Authors: Frothingham Michael G. , Mahan Kevin H. , Schulte‐Pelkum Vera , Goncalves Philippe , Zucali Michele 
Published: March 2023

AbstractSeismic anisotropy is controlled by aligned rock‐forming minerals, which most studies attribute to solid‐state shear with less consideration for magmatic fabric in plutonic rocks (rigid‐body rotation of crystals in the presence of melt). Our study counters this traditional solid‐state bias by evaluating contributions from fossil magmatic fabric. We collected samples from various tectonic settings, identified mineral orientations with electron backscatter diffraction and neutron diffraction, and calculated their bulk rock elastic properties. Results indicate that magmatic fabric may lead to moderate to strong anisotropy (3%–9%), comparable to solid‐state deformation. Also, magmatically aligned feldspar may cause foliation‐perpendicular fast velocity, a unique orientation that contrasts with a fast foliation typical of solid‐state deformation. Therefore, magmatic fabric may be more relevant to seismic anisotropy than previously recognized. Accordingly, increased considerations of magmatic fabric in arcs, batholiths, and other tectonic settings can change and potentially improve the prediction, observation, and interpretation of crustal seismic anisotropy.
GOLD Mission's Observation About the Geomagnetic Storm Effects on the Nighttime Equatorial Ionization Anomaly (EIA) and Equatorial Plasma Bubbles (EPB) During a Solar Minimum Equinox
Authors: Karan Deepak Kumar , Eastes Richard W. , Daniell Robert E. , Martinis Carlos R. , McClintock William E. 
Published: March 2023

AbstractThe nighttime ionospheric response to a geomagnetic storm that occurred on 23–29 September 2020 is investigated over the South American, Atlantic, and West African longitude sectors using NASA's Global‐scale Observations of the Limb and Disk measurements. On 27 September the solar wind conditions were favorable for prompt penetration electric fields to influence the equatorial ionosphere over extended longitudes. The equatorial ionization anomaly (EIA) crests were shifted 8°–10° poleward compared to the quiet time monthly mean across ∼65°–35°W during the main phase. Ionosonde hmF2 (peak electron density height) measurements from Fortaleza (GG: 3.9°S and 38.4°W) indicated a stronger prereversal enhancement this evening than other nights. As a result, equatorial plasma bubbles (EPB) occurred at these longitudes on this evening. This is the first simultaneous investigation of EIA morphology and EPB occurrence rate over an extended longitude range from geostationary orbit during a geomagnetic storm.
High Resolution Forecasting of Summer Drought in the Western United States
Authors: Abolafia‐Rosenzweig Ronnie , He Cenlin , Chen Fei , Ikeda Kyoko , Schneider Timothy , Rasmussen Roy 
Published: March 2023

AbstractDrought monitoring and forecasting systems are used in the United States (U.S.) to inform drought management decisions. Drought forecasting efforts have often been conducted and evaluated at coarse spatial resolutions (i.e., >10‐km), which miss key local drought information at higher resolutions. Addressing the importance of forecasting drought at high resolutions, this study develops statistical models to evaluate 1‐ to 3‐month lead time predictability of meteorological and agricultural summer drought across the western U.S. at a 4‐km resolution. Our high‐resolution drought predictions have statistically significant skill (p ≤ 0.05) across 70%–100% of the western U.S., varying by evaluation metric and lead time. 1‐ to 3‐month lead time drought forecasts accurately represent monitored summer drought spatial patterns during major drought events, the interannual variability of drought area from 1982 to 2020 (r = 0.84–0.93), and drought trends (r = 0.94–0.97). 71% of western U.S summer drought area interannual variability can be explained by cold‐season (November–February) climate conditions alone allowing skillful 3‐month lead time predictions. Pre‐summer drought conditions (represented by drought indices) are the most important predictors for summer drought. Thus, the statistical models developed in this study heavily rely on the autocorrelation of chosen agricultural and meteorological drought indices which estimate land surface moisture memory. Indeed, prediction skill strongly correlates with persistence of drought conditions (r ≥ 0.73). This study is intended to support future development of operational drought early warning systems that inform drought management.
SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation
Authors: Yi Xiuli , Wang Huina , Yang Yuqi , Wang Hao , Zhang Hengxiang , Guo Sen , Chen Jianru , Du Juan , Tian Yangzi , Ma Jingjing , Zhang Baolu , Wu Lili , Shi Qiong , Gao Tianwen , Guo Weinan , Li Chunying 
Published: March 2023

AbstractMelanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect, the prognosis of patients with melanoma is still suboptimal. During tumor progression, melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment. SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide (NAD+), with versatile biological functions in maintaining cell homeostasis. Nevertheless, whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains elusive. Herein, we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response. We first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon stress. Then, we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in vivo. Mechanistically, SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumor-promoting cytokines. SIRT7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal, which relieved the transcriptional repression on IRE1α and induced the activation of the IRE1α-XBP1 axis. Moreover, SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 axis. Additionally, the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also investigated. Taken together, SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy.
A new method assessing predicted and achieved mandibular tooth movement in adults treated with clear aligners using CBCT and individual crown superimposition
Authors: Alwafi Abdulraheem A. , Hannam Alan G. , Yen Edwin H. , Zou Bingshuang 
Published: March 2023

AbstractThe purpose of this study was to demonstrate a new method for quantifying the difference between predicted and achieved tooth movement with Invisalign using stable three-dimensional (3D) mandibular landmarks and dental superimposition. Cone-beam computed tomography (CBCT) scans before (T1) and after (T2) the first series of aligners, their corresponding digital models (ClinCheck initial of the first series as T1 and ClinCheck initial of the refinement series as T2), and the ClinCheck final model of the first series as the predicted were obtained from 5 patients treated with non-extraction Invisalign therapy. After segmentation of the mandible and its dentition, T1 and T2 CBCTs were superimposed on stable anatomic structures (Pogonion and bilateral mental foramen) along with the pre-registered ClinCheck models. The 3D prediction differences between the predicted and achieved tooth position for 70 teeth with four types (incisor, canine, premolar and molar) were measured using a combination of software. The method employed in this study was tested to be reliable and repeatable with a very high intraclass correlation coefficient (ICC) for both intra- and inter-examiner reliability. Premolar Phi (rotation), Incisor Psi (mesiodistal angulation), and Molar Y (mesiodistal translation) showed a significant prediction difference (P < 0.05), which is also clinically relevant. The method involving CBCT and individual crown superimposition to measure the 3D positional changes in the mandibular dentition is a robust and novel one. While, our finding in terms of the predictability of Invisalign treatment in the mandibular dentition mainly served as a crude, cursory examination, which warrants further and more rigorous investigations. With this novel methodology, it is possible to measure any amount of 3D tooth position difference in the mandibular dentition either between the simulated and the actual or with treatment and/or growth. Deliberate use of overcorrection of which specific type of tooth movement with clear aligner treatment and to what extent, might be possible with future studies.
An m7G-related lncRNA signature predicts prognosis and reveals the immune microenvironment in bladder cancer
Authors: Li Zhenchi , Zhao Jie , Huang Xing , Wang Jiangping 
Published: March 2023

AbstractBladder cancer (BC) is a representative malignant tumor type, and the significance of N7-methyguanosine (m7G)-related lncRNAs in BC is still unclear. Utilizing m7G-related lncRNAs, we developed a prognostic model to evaluate BC's prognosis and tumor immunity. First, we selected prognostic lncRNAs related to m7G by co-expression analysis and univariate Cox regression and identified two clusters by consensus clustering. The two clusters differed significantly in terms of overall survival, clinicopathological factors, and immune microenvironment. Then, we further constructed a linear stepwise regression signature by multivariate Cox and least absolute shrinkage and selection operator (LASSO) regression analysis. Patients fell into high-risk (HR) and low-risk (LR) groups considering the train group risk score. HR group had worse prognoses when stratified by clinicopathological factors. The receiver operating curve (ROC) suggested that the signature had a better prognostic value. Tumor mutation burden (TMB) showed a negative relevance to the risk score, and patients with low TMB presented a better prognosis. Validation of the signature was carried out with multivariate and univariate Cox regression analysis, nomogram, principal component analysis (PCA), C-Index, and quantitative reverse transcriptase PCR (qRT-PCR). Finally, the gene set enrichment analysis (GSEA) demonstrated the enrichment of tumor-related pathways in HR groups, and single-sample gene set enrichment analysis (ssGSEA) indicated a close association of risk score with tumor immunity. According to the drug sensitivity test, the signature could predict the effects of conventional chemotherapy drugs. In conclusion, our study indicates the close relevance of m7G-related lncRNAs to BC, and the established risk signature can effectively evaluate patient prognosis and tumor immunity and is expected to become a novel prognostic marker for BC patients.
Revisiting the inhibitory potential of protein kinase inhibitors against NEK7 protein via comprehensive computational investigations
Authors: Ejaz Syeda Abida , Aziz Mubashir , Zafar Zeenat , Akhtar Naveed , Ogaly Hanan A. 
Published: March 2023

AbstractThe NEK7 protein is required for spindle formation, cell division, and the activation of the NLRP3 inflammasome receptor. The aberrant expression of NEK7 has been implicated to the growth of metastasis and severe inflammatory conditions like rheumatoid arthritis, liver cirrhosis, and gout. An emergent target for the development of anti-cancer drugs is NEK7. In this context, the PubChem database was used to retrieve the 675 compound library and FDA-approved protein kinase inhibitors, which were then thoroughly examined via in-silico experiments. Computational studies investigated the binding orientation, electronic, and thermodynamic characteristics of drug candidates related to target protein. Drugs were investigated using density functional theory and molecular docking to find binding interactions with NEK7. Molecular dynamic simulations assessed interactions and stability of protein–ligand complex. DFT analyses showed that selected compounds maintained a significant amount of chemical reactivity in both liquid and gaseous states. Alectinib, Crizotinib, and compound 146476703 all displayed promising molecular interactions, according to molecular docking studies, with docking scores of − 32.76, − 30.54, and − 34.34 kJ/mol, respectively. Additionally, MD simulations determined the stability and dynamic characteristics of the complex over a 200 ns production run. The current study’s findings indicate that the drugs Alectinib, Crizotinib, and compound 146476703 can successfully inhibit the overexpression of the NEK7 protein. To discover more potent drugs against NEK7, it is recommended to synthesize the derivatives of Alectinib and Crizotinib and carry out additional in-vitro and in-vivo studies at the molecular level.
A hybrid prediction method for short‐term load based on temporal convolutional networks and attentional mechanisms
Authors: Li Min , Tian Hangwei , Chen Qinghui , Zhou Mingle , Li Gang 
Published: March 2023

AbstractAccurate power load prediction is an important guide for power system planning and operation. High‐ or low‐load prediction results will affect the operation of the power system. In recent years, deep learning technology represented by convolution neural network (CNN) and transformer has been proved to be suitable for power load prediction. This paper proposes a new short‐term power load hybrid forecasting model, called channel enhanced attention (CEA) and temporal convolutional network (TCN)‐based transformer comprehensive forecasting model. This method combines the short‐term feature extraction ability of TCN with the long‐term dependent capture ability of transformer for short‐term load forecasting. And the CEA designed in this study is added to improve the prediction accuracy. On the same dataset, the designed model predicts power load mean square errors of 0.056 and 0.146 for the next 24 h and the next week, respectively, which is 0.002 to 0.073 and 0.012 to 0.024 lower than the baseline model. The experimental results show that the hybrid short‐term power load prediction model proposed in this paper is significantly better than the existing methods. The predicted curve is in agreement with the actual charge change, which provides a good guidance for short‐term power load prediction.
Gorilla tropical optimization algorithm solution for performance enhancement of offshore wind farm
Authors: Mohamed Nour A. , Hasanien Hany M. , Al‐Ammar Essam A. , Tostado‐Véliz Marcos , Turky Rania A. , Jurado Francisco , Badr Ahmed O. 
Published: March 2023

AbstractThis article describes a technique for improving the performance of an offshore wind farm (OWF), which includes a permanent magnet synchronous generator (PMSG) driven by a variable‐speed wind turbine (VSWT) and connected to the grid through a high‐voltage direct current transmission system (HVDC). Under various network disturbances, the gorilla tropical optimization (GTO) metaheuristic method is used to fine‐tune the proportional‐integral (PI) controller gains for VSC‐based PMSG‐VSWT and VSC‐based HVDC transmission systems. This study compares several strategies for extracting the maximum power from a system while maintaining stability under symmetrical and unsymmetrical fault circumstances. Compared to different algorithms, GTO provides better results and improves system recovery and stability after disturbances. As a consequence, dynamic and transient stability may be enhanced. MATLAB/Simulink is used to implement the control mechanism.
Expert Consensus on the Interventional Treatment of Choledocholithiasis with Integrative Medicine
Authors: Liu Bin , Wang Zhongmin , Guo Jinhe , Wu Honglei , Zhang Kai , Yu Tao , Du Zhengguang , Zhao Wenxia , Jin Long , Liu Chongzhong , Fu Zan , Sun Jiangguang , Gao Kun , Shao Haibo , Feng Duiping , Shen Dongfeng , Jia Hongling , Li Yuliang 
Published: March 2023

AbstractPercutaneous transhepatic papillary balloon drainage (PTPBD) is a newly emerging interventional treatment modality for choledocholithiasis in China. Compared with other treatments, it has some advantages. Traditional Chinese medicine has been proven to have certain advantages in the treatment of choledocholithiasis, with reliable efficacy, few side effects, and a low recurrence rate. To standardize the clinical practice of choledocholithiasis, facilitate the application of PTPBD, and improve the diagnosis and treatment of integrative medicine, the Chinese College of Interventionalists organized multidisciplinary experts to discuss and formulate this consensus. This consensus aims to regulate the patient selection and technical process of PTPBD and the diagnosis and treatment scheme of integrative medicine.
Spectral shaping in a multimode fiber by all-fiber modulation
Authors: Finkelstein Zohar , Sulimany Kfir , Resisi Shachar , Bromberg Yaron 
Published: March 2023

In the past few years, there is a renewed interest in using multimode fibers for a wide range of technologies such as communication, imaging, and spectroscopy. However, practical implementations of multimode fibers in such applications are held back due to the challenges in dealing with modal dispersion, mode coupling, and the fiber’s sensitivity to mechanical perturbations. Here, we utilize these features of multimode fibers to generate all-fiber reconfigurable spectral filters. By applying computer-controlled mechanical deformations to the fiber along with an optimization algorithm, we manipulate the light propagation in the fiber and control its output field. Using this approach, we demonstrate tunable bandpass filters and dual-band filters with spectral resolutions as low as 5 pm.
Working memory and listening fatigue in cochlear implantation
Authors: Hamdy Mona , El Shennawy Amira , Mostafa Nourhan , Hamdy Hussein Sherif 
Published: March 2023

Background:
Hearing involves more than just the central auditory pathway’s operation and hearing threshold. Instead, the term ‘hearing’ encompasses a range of skills such as listening, comprehending, and communicating. As a result, a thorough assessment of the patient’s listening effort and working memory is critical.

Methods:
Forty-four subjects with cochlear implantation were included in the study, 22 patients as a study group and 22 subjects as a control group. They were assessed by digit span test for working memory, speech in noise test at different SNR levels, Fatigue assessment scale and Effort assessment scale.

Results:
There was a statistically significant difference in the Spin test between the study and control group. The study group showed a significant higher Spin scores at all SNR levels. There was a significant difference in both digit span forward and digit span backward tests between both the study and control group with a significant negative correlation between digit span and listening effort and fatigue scales. There was a significant statistical difference in the mean results of both the listening fatigue assessment scale and listening effort assessment scale between the study and control group where the study group showed a significant higher result in both scales.

Conclusion:
Assessing the effort associated with recognising speech is very valuable. Scales for measuring listening effort and listening fatigue as well as working memory can be easily incorporated into the basic audiological evaluation providing valuable insights for further rehabilitation.