bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMANFAATAN DIGITALISASI PENDIDIKAN DALAM PENGEMBANGAN KARAKTER PESERTA DIDIK
Authors: Sufyan Qurrotul A’yun , Ghofur Abdul 
Published: February 2023

Abstrak
Kehadiran dari peserta didik tentunya menjadi sebuah hal yang esensial didalam proses kegiatan belajar mengajar. Hal ini yang kemudian menjadikan peserta didik menjadi faktor yang sangat penting dalam pendidikan. Setiap peserta didik mempunyai sifat serta karakteristik yang tidak sama dengan yang lainnya. Oleh karena itu pendidik harus benar-benar mengetahui karakterisrtik dari masing- peserta didik tersebut. Perkembangan dalam dunia pendidikan saat ini, mengharuskan pendidik untuk beradaptasi terhadap penggunaan teknologi informasi dan komonikasi. Pemanfaatan dari TIK didalam proses belajar mengajar merupakan suatu bentuk transformasi sistem pembelajaran yang lebih mengarah kepada literasi baik guru dan peserta didik dalam penguasaan teknologi. Penggunaan dari teknologi memiliki dampak positif dan negatif, oleh karena itu diperlukan cara pandang yang netral sehingga menggunakan teknologi dengan bijak. Dalam artikel ini akan membahas mengenai pentingnya mengetahi karakter peserta didik, pendekatan belajar di era digital, memanfaatkan digitalisasi pendidikan dalam pengembangan karakter peserta didik.
Kata Kunci: digitalisasi pendidikan, karakter, peserta didik
Earthquake Risk Sensitivity Mapping at the Local Level for Sustainable RSLUP
Authors: Barua Uttama , Ansary Mehedi Ahmed , Islam Ishrat , Munawar Hafiz Suliman , Mojtahedi Mohammad 
Published: February 2023

Abstract
Risk-Sensitive Land Use Planning (RSLUP) is the process of mainstreaming disaster risk reduction and management parameters in land use planning. To ensure the effectiveness and sustainability of RSLUP, it is necessary to identify and understand the existing risk sensitivity of the land use plan. This research aims to develop a GIS-based multi-criteria zoning approach for mapping earthquake risk sensitivity of land use at local level. The methodology applied in this research is comprised of two steps. Firstly, assessment of the spatial earthquake risk sensitivity of the land use of an area based on the risk themes and corresponding risk attributes including both natural characteristics as well as built environment factors. Secondly, mapping of earthquake risk sensitivity by overlaying the spatial risk attribute maps based on weights determined through the Analytical Hierarchical Process (AHP). The research findings show that risk sensitivity map provides a guideline for policymakers to understand “where” and “why” RSLUP interventions are necessary. This research contributes to the theory and practices of disaster risk reduction and management by proposing a risk sensitivity assessment and mapping methodology. This will facilitate RSLUP at local level as a decision support system ensuring sustainability by reflecting the risk sensitivity accordingly and effectively.
Identifying Decision Support Needs for Emergency Response to Multiple Natural Hazards – an Activity Theory Approach
Authors: Gustafsson Viktor Sköld , Granberg Tobias Andersson , Pilemalm Sofie , Waldemarsson Martin 
Published: February 2023

Abstract
Planning and decision making in emergency responses systems face new challenges due to climate changes and the increased risk of multiple or compound natural hazards. This is especially the case in areas with inexperience of such events. The aim of this paper is to identify important activities concerning planning and decision-making during responses to natural hazards, and their potential need of decision support. The knowledge base of the study consists of interviews with 12 representatives from the Swedish emergency response system, supplemented by documents covering policies, operations, and responsibility. Thematic coding was applied to the interview data for identification of important planning and decision activities. Needs of decision support were identified by applying activity theory to the identified activities. We found needs of decision support connected to eight identified key activities concerning consequence analysis, national reinforcements, and resource management. The results illuminate a lack of technology to support response activities during both single and multiple natural hazards. The findings can inform policy makers in emergency response of where to concentrate the development of tools for collaborative preparedness and response work to cope with future challenges from natural hazards.
Resting state neurophysiology of agonist-antagonist myoneural interface in persons with transtibial amputation
Authors: Chicos Laura , Rangaprakash D. , Barry Robert , Herr Hugh 
Published: February 2023

Abstract

The agonist-antagonist myoneural interface (AMI) is a novel amputation surgery that preserves sensorimotor signaling mechanisms of the central-peripheral nervous systems. Our first neuroimaging study investigating AMI subjects (Srinivasan et al., Sci. Transl. Med. 2020) focused on task-based neural signatures, and showed evidence of proprioceptive feedback to the central nervous system. The study of resting state neural activity helps non-invasively characterize the neural patterns that prime task response. In this first study on resting state fMRI in AMI subjects, we compared resting state functional connectivity in patients with transtibial AMI (n=12) and traditional (n=7) amputations, as well as biologically intact control subjects (n=10). We hypothesized that the AMI surgery will induce functional network reorganization that significantly differs from the traditional amputation surgery and also more closely resembles the neural configuration of controls. We found AMI subjects to have lower connectivity with salience and motor seed regions compared to traditional amputees. Additionally, with connections affected in traditional amputees, AMI subjects exhibited a connectivity pattern more closely resembling controls. Lastly, sensorimotor connectivity in amputee cohorts was significantly associated with phantom sensation (R2=0.7, p=0.0008). These findings provide researchers and clinicians with a critical mechanistic understanding of the effects of the AMI surgery on the brain at rest, spearheading future research towards improved prosthetic control and embodiment.
Spatial pattern of Land use types and their driving mechanism of watershed lagged effect in Karst drainage basin, Central Guizhou of China*
Authors: he Zhonghua , Zhao Cuiwei , Liang Hong , Yang Zhaohui 
Published: February 2023

Abstract

The occurrence of drought indicates that there is no rainfall or little rainfall within a certain period. Nevertheless, no or little rainfall within a certain time implies that drought may not happen. The drought occurrence in different regions or seasons shows a certain lag to some extent. The lag time and intensity (i.e. the contribution rate of rainfall in previous period to runoff in current period) are deeply affected by watershed water storage capacity. Subsequently, rainfall deficit is a necessary and insufficient for the droughts. To reveal the mechanism of watershed lagged effects and the impact of human activities on droughts, the characteristics of lagged effects and human activities in Central Guizhou of China are analyzed by the Lagged index and Landscape index based on land use data, rainfall and runoff data during the period 1971–2016. The results demonstrate that the impact of the same land use type at different ages 1970s-2010s on watershed lagged intensity has a significant difference (P < 0.001). Among them, the impact of woodland, grassland and cultivated land gradually increases with the passage of time, and the cultivated land reaches the maximum in the 2000s. Nevertheless, the water body and construction land do not change significantly with the increase of years. The influence of land use type transfer on watershed lagged effect is particularly significant (P < 0.001). With the extension of lagged variables (periods), the impact of forest land type transfer on lag intensity gradually increases and reaches the maximum value at the lag-1 variable (Xt−1), and it is not of great significance for the rest of types. The impact of principal components (Zs) for morphological characteristics of land use types at different time scales (1–12 months), different lagged variables (Xt-Xt−3) and different ages (1970s-2010s) on watershed lagged effect is particularly significant (P < 0.001). Among them, this impact of grassland and water body on lagged intensity gradually increases with the time scales increasing and reaches the maximum value at the scale of 9 months, followed by the woodland and cultivated land, with reaching the maximum at the scales of 9 and 6 months respectively. Meanwhile, construction land is the smallest and reaches the maximum at the 9-month scale. As a subsequence, this study enriches the research content of landscape ecology, and it provides a theoretical basis for revealing the mechanism of agricultural and hydrological droughts in Karst drainage basins.
Effect of direct ultrasonic exposure on histopathology of ovaries, inflammatory and oxidative responses in dogs
Authors: Rajabi Arian , Mogheiseh Asghar , Nazifi Saeed , Ahrari-Khafi MohammadSaeed , Dehghanian AmirReza , Vesal Naser , Bigham-Sadegh Amin 
Published: February 2023

Abstract
Background: The harmful effect of ultrasonic waves on sex gonads may be a non-surgical spays method in dogs. This research was designed to evaluate the effects of ultrasound waves on ovarian germinal tissue and inflammatory cytokines (interleukin-6 (IL-6), IL1β, tumor necrosis factor-α (TNF-α)), acute phase proteins (serum amyloid A (SAA), C reactive protein (CRP)) and oxidative stress (total antioxidant capacity (TAC), and malondialdehyde (MDA)) in dogs. Twenty six clinically healthy adult mix-breed female dogs were aligned into three groups. Laparotomy was performed in control (n=6) and treatment (T5, n=10; T10, n=10) groups. The therapeutic ultrasonic transducer was used by round motions on the ovaries (1 MHz frequency, 1.5 W⁄cm2) for 5 min in T5 group and for 10 min in T10 group. Blood samples were collected from the jugular vein into plain glass tube on days 0 (before laparotomy), 3, 6 and 9 after surgery. Ovariectomy was conducted for histological evaluation on day 60.
Results: Direct exposure of ovaries with ultrasound waves induced inflammation and oxidative stress in compared with control group. Histopathological evaluation of treated ovaries with ultrasound waves indicated decrease number of primordial follicles (ovarian reserve) and oocyte preservation score in compared with controls.
Conclusions: These changes may be able to cause infertility and sterility in long term and it seems that inflammatory response and oxidative stress is a factor in the permanent damage of ovarian tissue.
Prognostic factors in undifferentiated uterine sarcoma – a subanalysis of the SARCUT study.
Authors: Mačuks Ronalds , Yildirim Yusuf , Mancari Rosanna , Achimas-Cadariu Patriciu , Madhuri Thumuluru K. , Ortega Eugenia , Mallmann Michael R. , Zapardiel Ignacio 
Published: February 2023

Abstract
Purpose
The aim of this study was to analyze the prognostic factors related to the recurrence rate and overall survival of patients with undifferentiated uterine sarcoma.
Methods
An international multicenter study involving 43 international centers, the SARCUT study, collected 966 uterine sarcoma cases; among them 39 cases corresponded to undifferentiated uterine sarcoma and where included in the present subanalysis. The risk factors related to the oncological outcomes where analyzed.
Results
The median age of the patients was 63 (range 14–85) years. Seventeen (43.5%) patients presented FIGO stage I. The 5-year overall survival (OS) was 15.3% and 12-months disease-free survival (DFS) 41%. FIGO stage I was significantly associated with a better prognosis. In addition, patients who received adjuvant radiotherapy showed significant longer disease-free survival compared to those without adjuvant radiotherapy (20.5 vs. 4.0 months, respectively; p = 0.04) and longer overall survival (34.7 vs. 18.2 months, respectively; p = 0.05). Chemotherapy administration was associated with shorter DFS (HR 4.41, 95% CI 1.35–14.43, p = 0.014). Persistent disease after primary treatment (HR = 6.86, 95%CI 1.51–31.09, p = 0.012) and FIGO stage IV (HR 4.12, 95%CI 1.37–12.44, p = 0.011) showed significant worse prognosis for OS.
Conclusion
FIGO stage seems to be the most important prognostic factor in patients with undifferentiated uterine sarcoma. Adjuvant radiotherapy seems to be significantly associated also to a better disease-free and overall survival. On the contrary, the role of chemotherapy administration remains unclear since was associated to a shorted DFS.
Climate change as a driver of insect invasions: Dispersal patterns of a dragonfly species colonizing a new region
Authors: Gil-Tapetado Diego , López-Collar Diego , Gómez Jose Francisco , Mañani-Pérez José , Cabrero-Sañudo Francisco José , Muñoz Jesús 
Published: February 2023

Abstract
The dragonfly Trithemis kirbyi Sélys, 1891 recently colonized Western Europe from North Africa. Since its first record in the Iberian Peninsula in 2007, the species has been spreading northward and has become naturally established in the central and eastern Iberian Peninsula, the Balearic Islands and southern France. Despite its worldwide distribution, its rapid colonization of the western Mediterranean area occurred only very recently. We found that the dispersal and recent establishment of T. kirbyi in southwestern Europe strongly depends on increasing temperatures, particularly summer temperature peaks, which has allowed this species to disperse farther and more effectively than during years with average summer temperatures. The most important variable in the suitability models is the minimum temperature of the coldest month, which, in recent decades, has become less of a limiting factor for ectotherms. According to the models, suitable areas for the species are currently found throughout the eastern Mediterranean parts of Europe, and it is likely that it can naturally colonize these areas as it did in the Iberian Peninsula. Trithemis kirbyi is a model of how climate change and observed rising temperatures have turned previously inhospitable regions into suitable areas for exotic species, which may successfully colonize them naturally if they can reach these promising lands on their own. However, this study serves as a warning that such species can also colonize these new regions with a little help from unsuspecting ‘friends’, which are often responsible for the increasingly common presence of invasive, noxious taxa in Europe.
A novel Genetically Engineered Microbial (GEM) biosensor for specific detection of Cd 2+ , Zn 2+ and Pb 2+ heavy metals; calibration and validation aspects
Authors: Herath H. M. L. P. B. , De Silva W. Rohini M. , Dassanayake R. S. , Gunawardene Y. I.N.S. , Jayasingha J. R. P. , Gayashan M. K. , Afonso L. O.B. , De Silva K. M. Nalin 
Published: February 2023

Abstract
Background
In this study, we designed a novel genetic circuit sensitive to Cd2+, Zn2+ and Pb2+ by mimicking the CadA/CadR operon system mediated heavy metal homeostasis mechanism of Pseudomonas aeruginosa. The regular DNA motifs on natural operon were reconfigured and coupled with the enhanced Green Fluorescent Protein (eGFP) reporter to develop a novel basic NOT type logic gate CadA/CadR-eGFP to respond metal ions mentioned above. A Genetically Engineered Microbial (GEM)-based biosensor (E.coli-BL21:pJET1.2-CadA/CadR-eGFP) was developed by cloning the chemically synthesised CadA/CadR-eGFP gene circuit into pJET1.2-plasmid and transforming into Escherichia coli (E. coli)-BL21 bacterial cells.
Results
The GEM-based biosensor cells indicated the reporter gene expression in the presence of Cd2+, Zn2+ and Pb2+ either singly or in combination. Further, the same biosensor cells calibrated for fluorescent intensity against heavy metal concentration generated linear graphs for Cd2+, Zn2+ and Pb2+ with the R2 values of 0.9809, 0.9761 and 0.9758, respectively as compared to non-specific metals, Fe3+ (0.0373), AsO43− (0.3825) and Ni2+ (0.8498) making our biosensor suitable for the detection of low concentration of the former metal ions in the range of 1–6 ppb. Furthermore, the GEM based biosensor cells were growing naturally within the concentration range of heavy metals, at 37 oC and optimum pH = 7.0 in the medium, resembling the characteristics of wildtype E.coli.
Conclusion
Finally, the novel GEM based biosensor cells developed in this study can be applied for detection of targeted heavy metals in low concentration ranges (1–6 ppb) at normal bacterial physiological conditions.
Air pollutant dispersion around high-rise building cluster forms: the case of Port City, Colombo, Sri Lanka
Authors: Vidanapathirana Malithie , Perera Narein , Emmanuel Rohinton , Coorey Shaleeni 
Published: February 2023

Abstract
Air quality in dense urban environments is a growing concern, especially in rapidly developing cities. In the face of growing traffic associated with urbanization, there is evidence for high levels of pollutant concentration at street level which is influenced by building forms. In this paper, we examine the potential effects of high-rise, cluster developments permitted by the local planning authorities in the newly established Port City development in Colombo, Sri Lanka. We designed possible building forms based on specific guidelines for the development in terms of plot coverage, floor area ratio, and maximum height. The three-dimensional building clusters were simulated using the RANS k-epsilon turbulence model, to determine pollutant dispersion of a complex street formation in a high dense high-rise building cluster, within the development and the surrounding context (existing Colombo).
Results show that in a complex building cluster there is no single building form which will provide uniformly better pollution dispersion across the development. Flow patterns are significantly affected by the building morphology, context, and ambient wind direction. Thus, individual building permits should be considered in their contexts and surrounding geometries need to be accounted for.
Unsupervised Outlier Detection for Time-Series Data of Indoor Air Quality Using LSTM Autoencoder with Ensemble Method
Authors: Park Junhyeok , Seo Youngsuk , Cho Jaehyuk 
Published: February 2023

Abstract
The proposed framework consists of three modules as an outlier detection method for indoor air quality data. We first use a long short-term memory autoencoder (LSTM-AE) based reconstruction error detector, which designs the LSTM layer in the shape of an autoencoder, to build a reconstruction error-based outlier detection model and extract latent features. The latent feature class-assisted vector machine detector constructs an additional outlier detection model using previously extracted latent features. Finally, the ensemble detector combines the two independent classifiers to define a new ensemble-based decision rule. Furthermore, because real-time anomaly detection proceeds with unsupervised learning, more stable and consistent external detection rules are defined than when using a single ensemble model. Laboratory tests with five random cases were performed for objective evaluation. Thus, we propose a framework that can be applied to various industrial environments by detecting and defining stable outlier decision rules.
Implementation of a Primary Care Asthma Management Quality Improvement Programme across 68 General Practice Sites
Authors: Gilchrist Francis , Carroll William , Clayton Sadie , Price David , Jarrold Ian , Small Iain , Sutton Emma , Lenney Warren 
Published: February 2023

Abstract
Introduction
Despite national and international guidelines, asthma is frequently misdiagnosed, control is poor and unnecessary deaths are far too common. Large scale asthma management programme such as that undertaken in Finland, can improve asthma outcomes.
Methods
A primary care asthma management quality improvement programme was developed with the support of the British Lung Foundation (now Asthma + Lung UK) and Optimum Patient Care (OPC) Limited. It was delivered and cascaded to all relevant staff at participating practices in three Clinical Commissioning Groups. The programme focussed on improving diagnostic accuracy, management of risk and control, patient self-management and overall asthma control. Patient data were extracted by OPC for the 12 months before (baseline) and after (outcome) the intervention.
Results
In the three CCGs, 68 GP practices participated in the programme. Uptake from practices was higher in the CCG that included asthma in its incentivised quality improvement programme. Asthma outcome data were successfully extracted from 64 practices caring for 673,593 patients. Primary outcome (Royal College of Physicians Three Questions [RCP3Q]) data were available in both the baseline and outcome periods for 10,328 patients in whom complete asthma control (RCP3Q=0) increased from 36.0% to 39.2% (p<0.001) after the intervention. The odds ratio of reporting complete asthma control following the intervention was 1.15 (95% CI 1.09-1.22), p<0.0001.
Conclusions
This asthma management programme produced modest but highly statistically significant improvements in asthma outcomes. Key lessons learnt from this small-scale implementation will enable the methodology to be improved to maximise benefit in a larger scale role out.
A Pure Mathematical Proof of the 4-Colour Theorem
Authors: Wang John 
Published: February 2023

Abstract
This work "A Pure Mathematical Proof of the 4-Colour Theorem" is related to the previous proof assited by computer. "Triangulations of Euler Convex Polygon" provides a fresh beginning point for the proof. The central concept is to discover an extended invariant property of Standard Graph’s boundary, which is described as "3-Colour All Phase States (3CP)" in this work and it is demonstrated that the standard graph’s boundary and sub-bound are 3CP and 4-colorable（4-3CP） via the expanded operation e(+, pi) and e(-, pi). It's exciting that this regularity was discovered for the first time and the 4-3CP invariant can naturally derive the 4-Colour Theorem. The majority of the definitions, theorems, and proof strategies are shown in this work.