bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capsular Contracture Rate in Augmentation Mammoplasty With Motiva Breast Implant Insertion: A Single-Center Experience in Korea
Authors: Lee Sangdal , Kim Minkuk , Kim Mi , Ryu Woosang , Back Seunghee 
Published: May 2023

Abstract

Background
Capsular contracture is the most common complication following breast implant surgery, and the implant shell characteristics are important in preventing this complication.

Objectives
The aim of this study was to evaluate the capsular contracture rate for SmoothSilk Motiva implants (Establishment Labs Holdings Inc., New York, NY) in females who underwent primary and revisional breast augmentation over a 3-year period.

Methods
A total of 1324 cases that took place from 2017 to 2020 were retrospectively analyzed, with 1027 being primary surgeries and 297 being revisional surgeries.

Results
In the 1324 cases of augmentation mammoplasty with SmoothSilk Motiva implants, the overall capsular contracture rate was 1.8% (n = 24). The capsular contracture rate in the 1027 primary surgery cases was 1.07% (n = 11), and the capsular contracture rate in the 297 revisional surgery cases was significantly different at 4.39% (n = 13, P = .0001). More specifically, the capsular contracture rate in 182 revisional surgery for cases without capsular contracture was 1.12% (n = 2), and it showed no statistically significant difference from the rate in primary surgery cases (P = .965). However, the rate in 115 revisional surgery for cases with capsular contracture was 9.57% (n = 11), and it showed a statistically significant difference from the rate in primary surgery cases (P = .000) and the rate in revisional surgery for cases without capsular contracture (P = .001).

Conclusions
Augmentation mammoplasty with SmoothSilk Motiva implants demonstrated a lower rate of capsular contracture than traditional smooth or textured implants. Revisional surgery for cases without capsular contracture showed a similar rate of capsular contracture to primary surgery cases, but the rates were higher in revisional surgery for cases with capsular contracture.

Level of Evidence: 4
Precision oncology: a review to assess interpretability in several explainable methods
Authors: Gimeno Marian , Sada del Real Katyna , Rubio Angel 
Published: May 2023

Abstract
Great efforts have been made to develop precision medicine-based treatments using machine learning. In this field, where the goal is to provide the optimal treatment for each patient based on his/her medical history and genomic characteristics, it is not sufficient to make excellent predictions. The challenge is to understand and trust the model’s decisions while also being able to easily implement it. However, one of the issues with machine learning algorithms—particularly deep learning—is their lack of interpretability. This review compares six different machine learning methods to provide guidance for defining interpretability by focusing on accuracy, multi-omics capability, explainability and implementability. Our selection of algorithms includes tree-, regression- and kernel-based methods, which we selected for their ease of interpretation for the clinician. We also included two novel explainable methods in the comparison. No significant differences in accuracy were observed when comparing the methods, but an improvement was observed when using gene expression instead of mutational status as input for these methods. We concentrated on the current intriguing challenge: model comprehension and ease of use. Our comparison suggests that the tree-based methods are the most interpretable of those tested.
Nonlinear data fusion over Entity–Relation graphs for Drug–Target Interaction prediction
Authors: Mazzone Eugenio , Moreau Yves , Fariselli Piero , Raimondi Daniele 
Published: May 2023

Abstract

Motivation
The prediction of reliable Drug–Target Interactions (DTIs) is a key task in computer-aided drug design and repurposing. Here, we present a new approach based on data fusion for DTI prediction built on top of the NXTfusion library, which generalizes the Matrix Factorization paradigm by extending it to the nonlinear inference over Entity–Relation graphs.

Results
We benchmarked our approach on five datasets and we compared our models against state-of-the-art methods. Our models outperform most of the existing methods and, simultaneously, retain the flexibility to predict both DTIs as binary classification and regression of the real-valued drug–target affinity, competing with models built explicitly for each task. Moreover, our findings suggest that the validation of DTI methods should be stricter than what has been proposed in some previous studies, focusing more on mimicking real-life DTI settings where predictions for previously unseen drugs, proteins, and drug–protein pairs are needed. These settings are exactly the context in which the benefit of integrating heterogeneous information with our Entity–Relation data fusion approach is the most evident.

Availability and implementation
All software and data are available at https://github.com/eugeniomazzone/CPI-NXTFusion and https://pypi.org/project/NXTfusion/.
The COVID-19 Pandemic’s Impact on UK Older People’s Social Workers: A Mixed-Methods Study
Authors: MacLochlainn Justin , Manthorpe Jill , Mallett John , McGrory Susan , Ravalier Jermaine , Nicholl Patricia , Schroder Heike , Currie Denise , McFadden Paula 
Published: May 2023

Abstract
The social work profession was heavily impacted by the COVID-19 pandemic. In this study, we examined the well-being, working conditions and intentions to leave the social work profession among a sample of UK older people’s social workers. This was a cross-sectional mixed methods study analysing data from 426 social workers who worked in older people’s services in the UK at five time points of the pandemic spanning 2020–2022. Data were collected using anonymous online surveys which included both quantitative and qualitative questions. The mental well-being of participants decreased as the pandemic progressed and this decline was associated with intentions to leave the profession. Thematic analysis of qualitative data revealed two major themes: Practice challenges and Staff well-being. The findings highlight the nature of stressors related to internal related practice demands, and external health and social care service stressors encountered during the COVID-19 pandemic and have implications for policy, practice and research in older people’s social work.
The functional role of the precuneus
Authors: Dadario Nicholas B , Sughrue Michael E 
Published: May 2023

Abstract
Recent advancements in computational approaches and neuroimaging techniques have refined our understanding of the precuneus. While previously believed to be largely a visual processing region, the importance of the precuneus in complex cognitive functions has been previously less familiar due to a lack of focal lesions in this deeply seated region, but also a poor understanding of its true underlying anatomy. Fortunately, recent studies have revealed significant information on the structural and functional connectivity of this region, and this data has provided a more detailed mechanistic understanding of the importance of the precuneus in healthy and pathologic states. Through improved resting-state functional MRI analyses, it has become clear that the function of the precuneus can be better understood based on its functional association with large scale brain networks. Dual default mode network systems have been well explained in recent years in supporting episodic memory and theory of mind; however, a novel ‘para-cingulate’ network, which is a subnetwork of the larger central executive network, with likely significant roles in self-referential processes and related psychiatric symptoms is introduced here and requires further clarification. Importantly, detailed anatomic studies on the precuneus structural connectivity inside and beyond the cingulate cortex has demonstrated the presence of large structural white matter connections, which provide an additional layer of meaning to the structural-functional significance of this region and its association with large scale brain networks. Together, the structural-functional connectivity of the precuneus has provided central elements which can model various neurodegenerative diseases and psychiatric disorders, such as Alzheimer’s disease and depression.
Microglial extracellular vesicles induce Alzheimer’s disease-related cortico-hippocampal network dysfunction
Authors: Falcicchia Chiara , Tozzi Francesca , Gabrielli Martina , Amoretti Stefano , Masini Greta , Nardi Gabriele , Guglielmo Stefano , Ratto Gian Michele , Arancio Ottavio , Verderio Claudia , Origlia Nicola 
Published: May 2023

Abstract
β-Amyloid is one of the main pathological hallmarks of Alzheimer’s disease and plays a major role in synaptic dysfunction. It has been demonstrated that β-amyloid can elicit aberrant excitatory activity in cortical-hippocampal networks, which is associated with behavioural abnormalities. However, the mechanism of the spreading of β-amyloid action within a specific circuitry has not been elucidated yet. We have previously demonstrated that the motion of microglia-derived large extracellular vesicles carrying β-amyloid, at the neuronal surface, is crucial for the initiation and propagation of synaptic dysfunction along the entorhinal–hippocampal circuit. Here, using chronic EEG recordings, we show that a single injection of extracellular vesicles carrying β-amyloid into the mouse entorhinal cortex could trigger alterations in the cortical and hippocampal activity that are reminiscent of those found in Alzheimer’s disease mouse models and human patients. The development of EEG abnormalities was associated with progressive memory impairment as assessed by an associative (object-place context recognition) and non-associative (object recognition) task. Importantly, when the motility of extracellular vesicles, carrying β-amyloid, was inhibited, the effect on network stability and memory function was significantly reduced. Our model proposes a new biological mechanism based on the extracellular vesicles–mediated progression of β-amyloid pathology and offers the opportunity to test pharmacological treatments targeting the early stages of Alzheimer’s disease.
Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla
Authors: Pizzuti Alessandra , Huber Laurentius (Renzo) , Gulban Omer Faruk , Benitez-Andonegui Amaia , Peters Judith , Goebel Rainer 
Published: May 2023

Abstract
Cortical columns of direction-selective neurons in the motion sensitive area (MT) have been successfully established as a microscopic feature of the neocortex in animals. The same property has been investigated at mesoscale (&lt;1 mm) in the homologous brain area (hMT+, V5) in living humans by using ultra-high field functional magnetic resonance imaging (fMRI). Despite the reproducibility of the selective response to axis-of-motion stimuli, clear quantitative evidence for the columnar organization of hMT+ is still lacking. Using cerebral blood volume (CBV)-sensitive fMRI at 7 Tesla with submillimeter resolution and high spatial specificity to microvasculature, we investigate the columnar functional organization of hMT+ in 5 participants perceiving axis-of-motion stimuli for both blood oxygenation level dependent (BOLD) and vascular space occupancy (VASO) contrast mechanisms provided by the used slice-selective slab-inversion (SS-SI)-VASO sequence. With the development of a new searchlight algorithm for column detection, we provide the first quantitative columnarity map that characterizes the entire 3D hMT+ volume. Using voxel-wise measures of sensitivity and specificity, we demonstrate the advantage of using CBV-sensitive fMRI to detect mesoscopic cortical features by revealing higher specificity of axis-of-motion cortical columns for VASO as compared to BOLD contrast. These voxel-wise metrics also provide further insights on how to mitigate the highly debated draining veins effect. We conclude that using CBV–VASO fMRI together with voxel-wise measurements of sensitivity, specificity and columnarity offers a promising avenue to quantify the mesoscopic organization of hMT+ with respect to axis-of-motion stimuli. Furthermore, our approach and methodological developments are generalizable and applicable to other human brain areas where similar mesoscopic research questions are addressed.
Early Flexible Sigmoidoscopy Improves Clinical Outcomes in Acute Severe Ulcerative Colitis
Authors: Sharma Shreyak , Li Darrick K , Levine Louis J , Chaar Abdelkader , McMillan Chandler , Gaidos Jill K J , Proctor Deborah D , Al-Bawardy Badr 
Published: May 2023

AbstractObjectivesGuidelines recommend performing a flexible sigmoidoscopy in patients hospitalized with acute severe ulcerative colitis (ASUC). However, it is unclear if time to sigmoidoscopy affects relevant clinical outcomes. We aimed to assess the impact of early sigmoidoscopy on clinical outcomes using a well-characterized cohort of patients with ASUC.MethodsThis is a single-center, retrospective study of all patients hospitalized with ASUC from January 1, 2012 to November 1, 2021. Early sigmoidoscopy was defined as occurring within 72 hours of admission while delayed sigmoidoscopy was defined as occurring &gt;72 hours after admission. Primary outcomes were cumulative days of intravenous (IV) corticosteroid (CS) use, length of hospital stay, and colectomy rates. Secondary outcomes were time to infliximab (IFX) rescue and inpatient opioid medication use.ResultsA total of 112 patients hospitalized with ASUC who underwent sigmoidoscopy were included in the analysis. Eighty-seven patients (78%) had early sigmoidoscopy and 25 (22%) had delayed sigmoidoscopy. Patients in the early sigmoidoscopy group were exposed to significantly fewer days of IV CS (4.5 vs 9.2 days; P &lt; .001), had shorter hospital stays (6.4 vs 19.3 days; P &lt; .001), and shorter time to IFX rescue (3.5 vs 6.4 days; P = .004). Rates of colectomy in the early and delayed sigmoidoscopy groups were 17% versus 28%, respectively (P = .23). Longer time to sigmoidoscopy was associated with a 16% increased risk of colectomy (HR = 1.16, P = .002).ConclusionsIn this well-characterized cohort, early sigmoidoscopy in ASUC was associated with favorable clinical outcomes. These findings highlight the benefits of early sigmoidoscopy in patients with ASUC. Larger prospective studies are needed to corroborate these findings.
Coronary microvascular health in symptomatic patients with prior COVID-19 infection: an updated analysis
Authors: Ahmed Ahmed Ibrahim , Al Rifai Mahmoud , Alahdab Fares , Saad Jean Michel , Han Yushui , Alfawara Moath Said , Nayfeh Malek , Malahfji Maan , Nabi Faisal , Mahmarian John J , Cooke John P , Zoghbi William A , Al-Mallah Mouaz H 
Published: May 2023

Abstract

Aims
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with endothelial dysfunction. We aimed to determine the effects of prior coronavirus disease 2019 (COVID-19) on the coronary microvasculature accounting for time from COVID-19, disease severity, SARS-CoV-2 variants, and in subgroups of patients with diabetes and those with no known coronary artery disease.

Methods and results
Cases consisted of patients with previous COVID-19 who had clinically indicated positron emission tomography (PET) imaging and were matched 1:3 on clinical and cardiovascular risk factors to controls having no prior infection. Myocardial flow reserve (MFR) was calculated as the ratio of stress to rest myocardial blood flow (MBF) in mL/min/g of the left ventricle. Comparisons between cases and controls were made for the odds and prevalence of impaired MFR (MFR &lt; 2). We included 271 cases matched to 815 controls (mean ± SD age 65 ± 12 years, 52% men). The median (inter-quartile range) number of days between COVID-19 infection and PET imaging was 174 (58–338) days. Patients with prior COVID-19 had a statistically significant higher odds of MFR &lt;2 (adjusted odds ratio 3.1, 95% confidence interval 2.8–4.25 P &lt; 0.001). Results were similar in clinically meaningful subgroups. The proportion of cases with MFR &lt;2 peaked 6–9 months from imaging with a statistically non-significant downtrend afterwards and was comparable across SARS-CoV-2 variants but increased with increasing severity of infection.

Conclusion
The prevalence of impaired MFR is similar by duration of time from infection up to 1 year and SARS-CoV-2 variants, but significantly differs by severity of infection.
A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance
Authors: Bigossi Margherita , Maroteau Cyrielle , Dawed Adem Y , Taylor Alasdair , Srinivasan Sundararajan , Melhem Alaa’ Lufti , Pearson Ewan R , Pola Roberto , Palmer Colin N A , Siddiqui Moneeza K 
Published: May 2023

ABSTRACT

Background and aims
The efficacy of statin therapy is hindered by intolerance to the therapy, leading to discontinuation. Variants in SLCO1B1, which encodes the hepatic transporter OATB1B1, influence statin pharmacokinetics, resulting in altered plasma concentrations of the drug and its metabolites. Current pharmacogenetic guidelines require sequencing of the SLCO1B1 gene, which is more expensive and less accessible than genotyping. In this study, we aimed to develop an easy, clinically implementable functional gene risk score (GRS) of common variants in SLCO1B1 to identify patients at risk of statin intolerance.

Methods and results
A GRS was developed from four common variants in SLCO1B1. In statin users from Tayside, Scotland, UK, those with a high-risk GRS had increased odds across three phenotypes of statin intolerance [general statin intolerance (GSI): ORGSI 2.42; 95% confidence interval (CI): 1.29–4.31, P = 0.003; statin-related myopathy: ORSRM 2.51; 95% CI: 1.28–4.53, P = 0.004; statin-related suspected rhabdomyolysis: ORSRSR 2.85; 95% CI: 1.03–6.65, P = 0.02]. In contrast, using the Val174Ala genotype alone or the recommended OATP1B1 functional phenotypes produced weaker and less reliable results. A meta-analysis with results from adjudicated cases of statin-induced myopathy in the PREDICTION-ADR Consortium confirmed these findings (ORVal174Ala 1.99; 95% CI: 1.01–3.95, P = 0.048; ORGRS 1.76; 95% CI: 1.16–2.69, P = 0.008). For those requiring high-dose statin therapy, the high-risk GRS was more consistently associated with the time to onset of statin intolerance amongst the three phenotypes compared with Val174Ala (GSI: HRVal174Ala 2.49; 95% CI: 1.09–5.68, P = 0.03; HRGRS 2.44; 95% CI: 1.46–4.08, P &lt; 0.001). Finally, sequence kernel association testing confirmed that rare variants in SLCO1B1 are associated with the risk of intolerance (P = 0.02).

Conclusion
We provide evidence that a GRS based on four common SLCO1B1 variants provides an easily implemented genetic tool that is more reliable than the current recommended practice in estimating the risk and predicting early-onset statin intolerance.
Need for improvement of cardiovascular health: a clustering method to identify cardiovascular health profiles.
Authors: Soyer Jessica , Gabet Amélie , Grave Clémence , Piffaretti Clara , Verdot Charlotte , Salanave Benoit , Deschamps Valérie , Fosse-Edorh Sandrine , Carcaillon-Bentata Laura , Olié Valérie 
Published: May 2023

Abstract

Background
In France, the overall trend in the incidence of cardiovascular disease is unfavourable, especially in young subjects. This highlights the need to promote cardiovascular health by targeting the main risk factors. Social marketing campaigns to improve cardiovascular health should identify unhealthy behaviour and understand the target audience. The objective of this study was to identify poor cardiovascular health profiles in the French population using a clustering method.

Methods
Subjects aged 18–74 years with no history of cardiovascular disease were included from the Esteban cross-sectional survey (2014–16). To evaluate cardiovascular health, seven items were considered as defined by the American Heart Association: blood glucose, blood cholesterol, blood pressure, body mass index, cigarette smoking, diet and physical activity. Cardiovascular health profiles were identified from these seven items by combining multiple correspondence analysis with hierarchical clustering and partitioning.

Results
A total of 1673 subjects were included in the main analysis. Five cardiovascular health profiles were identified: two profiles corresponded to subjects with poor cardiovascular health (mainly older men with a low socioeconomic status), two to subjects with intermediate cardiovascular health (one mainly comprised of young women with a low socioeconomic status and the other of young subjects with a high socioeconomic status) and one to subjects with good cardiovascular health (mainly older women).

Conclusion
This description of cardiovascular health profiles, which led to the identification and characterization of target audiences for future population-based prevention campaigns, should be the starting point for improving cardiovascular health in the French population.
ERK inhibition aids IFN-β promoter activation during EV71 infection by blocking CRYAB degradation in SH-SY5Y cells
Authors: Chen Dengming , Chen Cheng , Tan Jingyu , Yang Jing , Chen Bangtao 
Published: May 2023

AbstractEnterovirus 71 (EV71) can cause severe hand-foot-and-mouth disease with neurological complications. It has evolved multiple mechanisms to compromise the host type I interferon (IFN-I) response. In neuronal cells, EV71-mediated IFN-I antagonism may be associated with neural precursor cell-expressed developmentally downregulated 4-like (Nedd4L), the E3 ubiquitin ligase that can interact with alphaB-crystallin (CRYAB) in the regulation of Nav1.5 stability. Here, we investigated the effect of CRYAB stability on IFN-β promoter activity in neuronal SH-SY5Y cells infected with EV71, and its relations to Nedd4 L and extracellular signal-regulated kinases (ERK). Results showed that EV71 infection significantly caused CRYAB degradation via the Nedd4L-proteasome pathway, which required ERK-mediated phosphorylation of Serine 45 in CRYAB. Subsequently, it was observed that siRNA- or EV71-mediated CRYAB reduction limited Poly(dAT)-activated IFN-β promoter, and CRYAB stabilisation by U0126-mediated inhibition of ERK activation remarkably enhanced the activity of IFN-β promoter upon EV71 challenge. Collectively, we elucidate a novel mechanism by which ERK activation contributes to EV71 immune escape via CRYAB/IFN-β axis in SH-SY5Y cells, indicating that perturbing ERK activation is desirable for anti-EV71 therapy.
Inequality, Social Context, and Income Bias in Voting: Evidence from South Korea
Authors: Han Seungwoo , Kwon Hyeok Yong 
Published: May 2023

Abstract
The effect of inequality on income bias in voting is a contentious topic in the literature. In this article, we explore the effect of inequality in terms of social context. We argue that perceptions of inequality and regional economic inequality provide a social context in which citizens form relative class identity and shape their political behavior. We analyze individual-level surveys and administrative district-level data consisting of 252 South Korean administrative units in 2012–2020. The findings of the individual-level analysis suggest that perceptions of high inequality boost voter turnout, and that this effect is stronger among citizens with low incomes. As lower-income earners recognize themselves as being at a greater distance from the higher-income group, it activates a grievance effect and increases their incentive to participate in voting. The results from the district-level analysis suggest that the participation of lower-income individuals is more likely to increase in response to local inequality than the participation levels of their higher-income neighbors. Our findings suggest that the mass public utilizes their perceptions of inequality and the degree of intra-regional economic inequality as a heuristic to decide whether to turnout to vote, and that this occurs among both the rich and the poor.