bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS BENDING PADA KOMPOSIT SERAT ALAM DAUN AGEL DENGAN RESIN EPOXY
Authors: Sahuburua Stevward , Hartini Dwi , Adiputra Bangga Dirgantara 
Published: July 2023

The use of composite materials, especially those developed by natural fibers in various equipment, has begun to develop a lot, the use of natural agel leaf fibers as composite materials can reduce the use of synthetic materials and increase the utilization of agel leaf natural fibers which are still a lot of wasted. This study aims to determine the stages or processes of agel leaf natural fiber composite using 2 methods of hand lay up, vacuum bag and to determine the value of the bending strength of agel leaf natural fiber material between variations of the epoxy matrix in the direction of the fibers 0^° and 〖90〗^°.Based on the data from the test results, it can be concluded that the average value of maximum bending strength in agel leaf natural fiber composites using the vacuum bag manufacturing method with a volume fraction of 60% and fiber direction 0^° and 〖90〗^° has an average maximum bending strength value that is the highest, namely 11.006 MPa and 11.057 MPa and the composite of agel leaf natural fiber using the hand lay up method (non vacuum bag) with a volume fraction of 50%, 60%, 70% and fiber direction 0^° has the lowest average maximum bending strength values of 3.413 MPa, 5.404 MPa, 4.625 MPa.
Refugios artificiales para murciélagos en Nuevo León como una acción de conservación
Authors: Rivera-Villanueva Nalleli , Dalaí-López Samantha 
Published: July 2023

Los murciélagos son el segundo orden de mamíferos más diverso en el mundo, sólo después de los roedores. Existen más de 1,400 especies y representan cerca de 20% de toda la diversidad en el planeta. Esta gran variedad se ve reflejada en los distintos hábitos alimenticios que poseen y en los servicios ambientales que brindan, como el control de poblaciones de insectos, la polinización de plantas, la dispersión de semillas para la regeneración de bosques tropicales, entre otros (Kunz et al., 2011; Frick et al., 2020; Cirranello y Simmons, 2022).
Un vistazo al sistema de cannabinoides
Authors: Robles-Sierra Elda Josefina , González-Hernández Brenda 
Published: July 2023

Existen tres tipos de cannabinoides, su estudio ha estado íntimamente relacionado entre sí, por lo que en ocasiones es difícil hablar de unos sin mencionar a los otros.
Los primeros en ser descubiertos fueron los fitocannabinoides, que vienen de la planta Cannabis spp. (Linneo, 1753).

Después de este descubrimiento se identificaron receptores que modulan la respuesta al uso del cannabis, lo cual fue apoyado con el diseño de lo que ahora conocemos como cannabinoides sintéticos.
Understanding what really helps to ensure access to diagnostic services in the Indian Public Health System: a realist synthesis of the Common Review Mission reports (2007-2021)
Authors: Hannah Erin , Basheer Nisha , Dumka Neha , Kotwal Atul 
Published: July 2023

Background In India, the National Health Mission (NHM) has been supporting the states in building an integrated public healthcare network across the levels of care. This effort has improved access to, and utilization of, diagnostic services at public healthcare facilities. To continually enhance citizens’ ability to seek and avail quality and affordable services, it is imperative to take stock of various components of the diagnostic ecosystem that may be common or unique to states and understand their influence on equipping the health system. The objective of the study was to understand key health system factors augmenting or limiting access to diagnostic services and outcomes. Methods Common Review Mission (CRM) reports between 2007 and 2021 were selected for the study. Data relevant to diagnostic services were retrieved using defined search terms. The data were segregated for each Indian state and categorized under the pre-determined themes: state-specific practices, key findings, and challenges. Analysis of the data was done iteratively to identify the themes emerging from the reports over the years. Each theme was analysed further to deduce context-specific enablers and barriers influencing access to diagnostic service delivery. Results The major themes that emerged include (i) the approach to health systems strengthening, (ii) efficiency of procurement and distribution systems, (iii) infrastructure, (iv) modes of service delivery, (v) implementation of Free Diagnostic Service Initiative, Comprehensive Primary Health Care and Biomedical Equipment Management and Maintenance Program, and (vi) quality of care , and (vii) diagnostic service outcomes. Conclusions In a complex adaptive system, access to diagnostic services depends on the concurrent strengthening of various health system components across the levels of care. The nation has strategized accessible, affordable and acceptable diagnostic services to achieve universal health coverage and care-continuum pathways. States need to leverage the existing mechanisms, assess their implementation, and arrive at feasible and sustainable solutions to strengthen access to diagnostic services.
A study conducted in a tertiary care hospital to assess the cardiac function in paediatric beta thalassemia major patients and correlation with serum ferritin levels which are indicative of chelation status of the patients
Authors: Rao Jayashree Satish , K Nagendra 
Published: July 2023

Background: Thalassemia is one of the common inherited blood disorders and Beta Thalassemia Major is a homozygous form of deficiency of beta globin chain synthesis causing severe transfusion-dependent anemia, manifesting between 6 and 24 months of life. Objectives: The objective of the study is to study the pattern of cardiac function in children and adolescents with beta-thalassemia major by 2D Echocardiography and its correlation with serum ferritin levels. Methods: Fifty subjects diagnosed with Beta Thalassemia Major, after applying the inclusion and exclusion criteria were included in Group 1, and 50 age and gender-matched subjects without Beta Thalassemia Major were included in Group 2. Serum ferritin level was measured using Cobas 6000 analyzer. Echocardiography was done with the following parameters: Posterior wall thickness-diastolic (PWT-D), posterior wall thickness- systolic (PWT-S), left ventricular internal diameter-diastole (LVID-D), left ventricular internal diameter-systole (LVID-S), septal thickness and tricuspid regurgitation (TR) velocity. Results: Among the 50 study population, 28 children belonged to the age group 5–10 years (56%) and 22 children belonged to the age group 10–15 years (44%). Among the cardiac parameters, The PWT-D, PWT-S, LVID-D, LVID-S, TR velocity, and septal thickness values were higher in the cases group compared to the control group with p values suggesting strong significance. The ejection fraction in the cases was lower than the control group with a strongly significant p-value. Conclusion: Children with thalassemia have impaired cardiac function and the degree of dysfunction is correlated to the serum ferritin levels. Regular transfusion and adequate chelation are essential to decrease morbidity and mortality.
The February 2018 seismic swarm in São Miguel, Azores
Authors: Soares A. , Custódio S. , Cesca S. , Silva R. , Vuan A. , Mendes V. B. 
Published: July 2023

The island of São Miguel is among the most seismically active areas of the Azores archipelago. This work focuses on the most significant recent swarm, which occurred on February 2018. We set up an automated procedure to process continuous full seismic waveform data from local stations to generate high-quality earthquake information on the volcano unrest episode. First, we applied an automated detector software, next we located the detected events and then classified the earthquakes based on their waveform similarity, identifying three families of seismic events. We then extended the catalog by template matching. Finally, we computed moment tensors to investigate the source mechanisms of the largest earthquakes. Our results image the ∼2-week swarm evolution. The activity started with a precursory phase with low rate and low magnitude (ML &lt; 2.0) seismicity and the activation of a deeper structure (∼10-15 km). After ∼1 week, a new earthquake family emerged at shallower depths (∼8–12 km) reaching magnitudes up to ML 3.4. Finally, a third slightly shallower family was activated. Moment tensors show mostly normal faulting mechanisms, striking ∼NW-SE, compatible with the orientation of the regional stress field. A surface deformation transient was recorded by geodetic stations, starting with the swarm, and continuing over the following ∼17 months, corresponding to either inflation or extension around the swarm region. The prolonged surface deformation implies a process that was initiated during the swarm and subsequently accommodated mostly aseismically. We interpret the seismicity observed at the early stage of deformation as indicating episodic fluid injection through the crust, related to the local hydrothermal or magmatic systems. We conclude that the Fogo-Congro region continues to be seismo-volcanically active, with both seismic and aseismic deformation observed and requiring close multidisciplinary monitoring. The proposed methology based on the automated analysis of continuous waveform data provides high-quality imaging of the spatio-temporal evolution of seismicity, which can be used elsewhere in the operational monitoring of seismo-volcanic crises to gain insight into the ongoing deformation processes, improve hazard assessment and help in the development of effective mitigation strategies.
Effect of digital transformation on innovation performance in China: corporate social responsibility as a moderator
Authors: Wang Lei , Yan Jinzhe 
Published: July 2023

Introduction: In the digital economy, digital transformation (DT) is a deliberate decision to improve organizational procedures, alter production processes, introduce precision marketing, and more, ultimately impacting how well businesses innovate. This is why the current article investigates the effect of DT and the firm’s innovation performance and the boundary condition of corporate social responsibility (CRS).Method: This study proposed a conceptual research model for the effect of DT on innovation performance and discussed the boundary condition of CRS. We collected China’s listed A-share firms’ data to examine the proposed hypotheses statistically. After Hausman test, the current study adopted fixed-effect regression, examined the heterogeneity issues resulting from different industry classifications, and robustness test for the correctness of the results.Results and Implications: The following main conclusions are drawn: 1) DT can significantly enhance product innovation performance; 2) DT can significantly improve process innovation performance; 3) There is a time lag effect on the innovation performance (both product and process innovation performance) of the previous period on the innovation performance of the current period; 4) CSR positively moderates the role of DT on innovation performance; and 5) The impact of DT is heterogeneous across industries and patent. This study not only enriched the literature on DT and innovation performance but also provided the guidelines to promote digital transformation at the firm level.
Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis
Authors: He Xu , Zhang Juqi , Gong Mingli , Gu Yanlun , Dong Bingqi , Pang Xiaocong , Zhang Chenglong , Cui Yimin 
Published: July 2023

BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and gradual joint degeneration, resulting in function disability. Recently, ferroptosis, a novel form of regulated cell death that involves iron-dependent lipid peroxidation, has been implicated in the pathogenesis of RA. However, the underlying molecular mechanisms and key genes involved in ferroptosis in RA remain largely unknown.MethodsThe GSE134420 and GSE77298 datasets were downloaded and DEGs were identified using R software. The DEGs were then mapped to the dataset of 619 ferroptosis-related genes obtained from the GeneCards database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were conducted to investigate the possible biological functions. Protein-protein interaction (PPI) networks were constructed to identify the hub genes. The relationship between hub genes and immune infiltration was estimated using the CIBERSORT algorithms. Gene Set Enrichment Analysis (GSEA) was used to explore the underlying signaling pathways of hub genes. Genome-wide association studies (GWAS) analysis was performed to confirm the pathogenic regions of the hub genes. RcisTarget and Gene-motif ranking databases were used to identify transcription factors (TFs) associated with the hub genes. The miRcode databases were utilized to construct the microRNA (miRNA)-messenger RNA (mRNA) network. Single-cell analysis was utilized to cluster cells and display the expression of hub genes in cell clusters. Finally, the expression and potential mechanism of hub genes were investigated in human and experimental samples.ResultsThree hub genes PTGS2, ENO1, and GRN highly associated with ferroptosis were identified. Four pathogenic genes HLA-B, MIF, PSTPIP, TLR1 were identified that were significantly and positively correlated with the expression levels of hub genes. The results of the GSEA showed that the hub genes were significantly enriched in pathways related to immunity, lysosome, phagocytosis and infection. ENO1 and PTGS2 were enriched in the TF-binding motif of cisbp_M5493. The hub genes were validated in experimental and patient samples and highly level of ENO1 expression was found to inhibit ACO1, which reduces ferroptosis in proliferating fibroblast-like synoviocytes (FLS).ConclusionPTGS2, ENO1 and GRN were identified and validated as potential ferroptosis-related biomarkers. Our work first revealed that ENO1 is highly expressed in RA synovium and that ferroptosis may be regulated by the ENO1-ACO1 axis, advancing the understanding of the underlying ferroptosis-related mechanisms of synovial proliferation and providing potential diagnostic and therapeutic targets for RA.
Rasch validation of a new scale to measure dependency in arm use in daily life: the Upper Limb Lucerne ICF-based Multidisciplinary Observation Scale
Authors: Van de Winckel Ann , Ottiger Beatrice , Veerbeek Janne Marieke , Nyffeler Thomas , Vanbellingen Tim 
Published: July 2023

IntroductionAbout 77% of adults with stroke have upper limb impairments. Many scales are available to measure the impairment and activity level of the affected limb. However, an observational scale to assess dependency on others in upper limb performance during daily life activities instead of laboratory settings is lacking. Therefore, we developed a new 5-item Upper Limb Lucerne ICF-based Multidisciplinary Observation Scale (UL-LIMOS). As next step in the psychometric analysis, we evaluated the unidimensionality and structural validity of the UL-LIMOS with Rasch Measurement Theory and we calculated a cut-off score for independent arm use in daily life activities at discharge.MethodsThis is a single-center cross-sectional study in adults with (sub) acute stroke. We applied Rasch Measurement Theory (RMT) to analyze the structural validation and unidimensionality of the UL-LIMOS. The outputs provide evidence of unidimensionality, item and person fit, overall fit, differential item functioning (DIF), principal component analysis of residuals (PCAR), person separation reliability (PSR), and residual item correlations (to identify local item dependence). Person mean location, floor and ceiling effects identify proper targeting.ResultsWe recruited 407 adults with (sub) acute stroke (median age 63 years, 157 women). All items and persons fit the Rasch model. The PSR of 0.90 indicates that clinicians and researchers can reliably use the scale for individual decision-making. There were small floor (2.70%) and ceiling (13.00%) effects. The average person mean location was 1.32 ± 2.99 logits. There was no DIF. PCAR eigenvalue was 2.46 with 49.23% explained variance. Paired t-tests revealed that 0.89% of person locations were significantly different, confirming unidimensionality. One pair of items (arm and hand use and fine hand use) showed residual item correlations. The ROC’s AUC was 0.90, CI95% = [0.85–0.96] with cut-off score of ≥14/20, and high sensitivity (87%, CI95% = [81%–91%]), specificity (83%, CI95% = [77%–87%]) for independent arm use in daily living at discharge.DiscussionThe new Rasch-based UL-LIMOS is a valid ICF-based observation performance scale at the ICF-activity level, to evaluate dependency during upper limb use in daily life in adults with stroke. Additional psychometric analyses are warranted. The UL-LIMOS would be a valuable addition to the core assessments of adults with (sub) acute stroke.
Multiple micronutrient deficiencies alter energy metabolism in host and gut microbiome in an early-life murine model
Authors: Littlejohn Paula T. , Bar-Yoseph Haggai , Edwards Karlie , Li Hong , Ramirez-Contreras Cynthia Y. , Holani Ravi , Metcalfe-Roach Avril , Fan Yiyun M. , Yang Tom Min-Shih , Radisavljevic Nina , Hu Xiaoke , Johnson James D. , Finlay B. Brett 
Published: July 2023

IntroductionMicronutrients perform a wide range of physiological functions essential for growth and development. However, most people still need to meet the estimated average requirement worldwide. Globally, 2 billion people suffer from micronutrient deficiency, most of which are co-occurring deficiencies in children under age five. Despite decades of research, animal models studying multiple micronutrient deficiencies within the early-life period are lacking, which hinders our complete understanding of the long-term health implications and may contribute to the inefficacy of some nutritional interventions. Evidence supporting the Developmental Origins of Health and Disease (DOHaD) theory demonstrates that early-life nutritional deficiencies carry life-long consequences mediated through various mechanisms such as abnormal metabolic programming, stunting, altered body composition, and the gut microbiome. However, this is largely unexplored in the multiple micronutrient deficient host.Methodswe developed a preclinical model to examine undernutrition’s metabolic and functional impact on the host and gut microbiome early in life. Three-week-old weanling C57BL/6N male mice were fed a low-micronutrient diet deficient in zinc, folate, iron, vitamin A, and vitamin B12 or a control diet for 4-weeks.ResultsOur results showed that early-life multiple micronutrient deficiencies induced stunting, altered body composition, impaired glucose and insulin tolerance, and altered the levels of other micronutrients not depleted in the diet within the host. In addition, functional metagenomics profiling and a carbohydrate fermentation assay showed an increased microbial preference for simple sugars rather than complex ones, suggestive of a less developed microbiome in the low-micronutrient-fed mice. Moreover, we found that a zinc-only deficient diet was not sufficient to induce these phenotypes, further supporting the importance of studying co-occurring deficiencies.DiscussionTogether, these findings highlight a previously unappreciated role of early-life multiple micronutrient deficiencies in shaping the metabolic phenome of the host and gut microbiome through altered glucose energy metabolism, which may have implications for metabolic disease later in life in micronutrient-deficient survivors.
The impact of high-glucose or high-fat diets on the metabolomic profiling of mice
Authors: Xie Dadi , Zhang Yanbo , Guo Yujin , Xue Xianzhong , Zhao Shiyuan , Geng Chunmei , Li Yuanyuan , Yang Rui , Gan Yizhang , Li Hanbing , Ren Zhongfa , Jiang Pei 
Published: July 2023

ObjectiveDiets high in glucose or fat contribute to an increased prevalence of the diseases. Therefore, the objective of the current research was to observe and evaluate the impact of dietary components on different metabolomic profiles in primary tissues of mice.MethodsFor 8 weeks, diet with high-glucose or-fat was given to C57BL/6 J mice. The levels of metabolites in the primary tissues of mice were studied using gas chromatography-mass spectrometry (GC-MS) and analyzed using multivariate statistics.ResultsBy comparing the metabolic profiles between the two diet groups and control group in mice main tissues, our study revealed 32 metabolites in the high-glucose diet (HGD) group and 28 metabolites in the high-fat diet (HFD) group. The most significantly altered metabolites were amino acids (AAs; L-alanine, L-valine, glycine, L-aspartic acid, L-isoleucine, L-leucine, L-threonine, L-glutamic acid, phenylalanine, tyrosine, serine, proline, and lysine), fatty acids (FAs; propanoic acid, 9,12-octadecadienoic acid, pentadecanoic acid, hexanoic acid, and myristic acid), and organic compounds (succinic acid, malic acid, citric acid, L-(+)-lactic acid, myo-inositol, and urea). These metabolites are implicated in many metabolic pathways related to energy, AAs, and lipids metabolism.ConclusionWe systematically analyzed the metabolic changes underlying high-glucose or high-fat diet. The two divergent diets induced patent changes in AA and lipid metabolism in the main tissues, and helped identify metabolic pathways in a mouse model.
Comparison of primary hepatic neuroendocrine tumors and non-hepatitis B non-hepatitis C hepatocellular carcinoma on contrast-enhanced ultrasound
Authors: Tan Zhizhi , Li Jiawu , Wu Zhenru , Zhou Zhengling , Yang Lulu , Luo Yan 
Published: July 2023

ObjectiveThe purpose of this study was to compare the sonographic features of primary hepatic neuroendocrine tumors (PHNETs) to those of non-hepatitis B and non-hepatitis C hepatocellular carcinoma (NBNC-HCC) on contrast-enhanced ultrasound (CEUS).Materials and methodsFourteen patients with a mean age of 56.9 ± 12.2 (SD) years with histopathologically confirmed PHNET were included in the study. Twenty-eight patients with a mean age of 58.5 ± 10.4 years with histopathologically confirmed NBNC-HCC were randomly selected as the control group. The clinical data, conventional ultrasound and CEUS features were retrospectively analyzed between PHNET and NBNC-HCC.ResultsPHNET was more common in women (57.1%, 8/14 cases), and NBNC-HCC was more common in men (75.0%, 21/28) (P=0.040). No significant differences were observed in etiology, tumor marker, and liver function between the two group (P&gt;0.05). Conventional ultrasound revealed that the tumor size of PHNET (10.1 ± 4.7 cm) was larger than that of NBNC-HCC (5.9 ± 3.8 cm) (P=0.006). NBNC-HCC was predominantly hypoechoic, while the echogenicity of PHNET varied (P=0.001). On CEUS, 57.1% (8/14) of PHNETs showed heterogeneous hyperenhancement, whereas 77.0% (21/28) of NBNC-HCC presented homogeneous hyperenhancement (P=0.015). Furthermore, 35.7% (5/14) of PHNETs showed early washout (onset of washout &lt;60 s), which was significantly different from that of NBNC-HCC (3.7%, 1/28) (P=0.005).ConclusionCEUS is helpful in discriminating between PHNET and NBNC-HCC. PHNETs mainly present as a single mass with a large size (&gt;10 cm) in the liver. The CEUS showed that most PHNETs exhibited heterogeneous enhancement in the arterial phase, washout in the portal venous and late phases and early washout being more likely than NBNC-HCC. However, more imaging features need to be evaluated in a larger sample.