bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential implications of cosmetic BoNT-A use on future treatment options for neuromuscular disorders and pain
Authors: Dingley Mary 
Published: July 2023

Potential implications of cosmetic BoNT-A use on future treatment options for neuromuscular disorders and pain
Given the rise in cosmetic procedures involving BoNT-A, cosmetic physician Dr Mary Dingley discusses the therapeutic implications of antibody-induced resistance on future treatment of various conditions, including post-stroke spacticity and pain disorders. Botulinum neurotoxin type A (BoNT-A) is produced by the Clostridium botulinum bacterium and is the most powerful neurotoxin known. But it is also a very useful medication. It is used to treat the symptoms of neuromuscular disorders such as cervical dystonia, cerebral palsy, post-stroke spasticity, and migraine and pain disorders. It is also a key part of the frequently used, minimally invasive cosmetic procedure called ‘BOTOX’. However, the increasing aesthetic use of BoNT-A raises concerns that this may render the substance therapeutically useless or ineffective.
Quantum network technology
Authors: Wehner Stephanie 
Published: July 2023

Quantum network technology
Prof Dr Stephanie Wehner, Director of the European Quantum Internet Alliance, explains how quantum network technology and a quantum internet could revolutionise communication and connectivity. The internet, an intricate network connecting devices across the globe with classical communication, has profoundly shaped our world. We now stand on the brink of a new type of internet. Imagine an evolution of the internet, one that intertwines the principles of quantum mechanics with our existing digital technology. This is the vision of a quantum internet - an innovation that promises to redefine our understanding of communication and connectivity. Working in tandem with our traditional ‘classical’ internet, a quantum internet would connect quantum devices globally. Such a network would unlock capabilities that are fundamentally unattainable through classical communication alone. Take, for instance, Quantum Key Distribution (QKD), a striking application of quantum communication. QKD allows two distant nodes to create an encryption key guarded by the immutable principles of quantum mechanics.
Innovative dynamic molding to reduce development costs of personalized medicine
Authors: Barthès Julien 
Published: July 2023

Innovative dynamic molding to reduce development costs of personalized medicine
Dr Julien Barthès, Dr Edwin-Joffrey Courtial, and Dr Christophe Marquette of 3Deus Dynamics SAS have raised €2.5 million for the industrialization of its 3D process, to expand internationally and revolutionize personalized medicine with Dynamic Molding. This grant will allow the start-up to deploy its process by setting up a first production line dedicated to the manufacture of customized silicone medical devices. This funding will help the healthcare sector with its mass customization needs thanks to the manufacturing of patient-specific medical devices in silicone with total freedom of design without chemical reformulation or support structure, excellent mechanical fidelity and durability. These Dynamic Molds are exceptionally flexible, allowing them to mimic the mechanics and morphology of native tissue, they arealso waterproof, suturable and perfusable and compatible with the use of medical imaging. They are a responsible alternative to the use of cadavers or animals and allow a return of touch to a specific pathology.
The emergence of precision medicine for oncology
Authors: Hays Priya 
Published: July 2023

The emergence of precision medicine for oncology
Dr Priya Hays, PhD, considers how the rapid development of precision medicine for oncology has impacted diagnosis, treatment, and clinical outcomes in cancer care. Personalised medicine, also referred to as precision medicine, had its early conceptual foundations in the Human Genome Project, the multi-institutional effort to sequence the entire base pair sequences of the human genome, or DNA sequences in the cell. The sequencing revealed variations between individuals in their DNA sequences. This variation, or what came to be known as genomic variation, could be mobilised to differentiate diagnosis and treatment between individual genomes. Targeted therapies - small molecule inhibitors designed to attack cancer cells exclusively by affecting signalling pathways - were developed as viable treatment options defined by the personalised medicine pathway.
E-Learning platform for dementia caregivers
Authors: Kwok Timothy , Ho Florence , Wong Bel , Cheng Tobi 
Published: July 2023

E-Learning platform for dementia caregivers
Jockey Club Centre for Positive Ageing is developing a multimedia e-learning platform for dementia caregivers; here, they share the vast benefits. Taking care of a loved one who has dementia is a challenging task for family members. According to an opinion survey conducted by Jockey Club Centre for Positive Ageing (JCCPA), almost 90% of caregivers reported experiencing stress while caring for a family member with dementia, with about half of them experiencing frequent episodes of stress.(1) Data indicates that family members who assume the primary role of caring for individuals with dementia experience a significant burden of caregiving. On average, caregivers devote between five and 20 hours per day to caring for these individuals.(2) Extended caregiving hours can reduce the time available for rest and social engagement, leading to feelings of loneliness and social isolation.(3) It is common for caregivers to experience high levels of depression.(4)
A long-term retrospective observational study at a medium-sized medical oncology service in Switzerland: comparison of overall survival with a national cohort and adherence to treatment guidelines
Authors: Gross-Erne Mirjam , Zimmerli Lukas , Bassetti Stefano , Li Qiyu , Feller Anita , Mingrone Walter 
Published: July 2023

AIMS: There is a lack of national and international publicly available long-term survival outcome data from individual healthcare providers in medical oncology. In this study, the overall survival at a medium-sized medical oncology service at Olten Cantonal Hospital was evaluated and compared as a local benchmark report with national data from the Swiss Cancer Registries. Furthermore, adherence to treatment guidelines was investigated as an additional quality indicator.
METHODS: The 1- and 5-year overall survival of all patients with breast cancer, testicular cancer, colon cancer, non-small-cell lung cancer, Hodgkin lymphoma, and diffuse large B-cell lymphoma in Switzerland from 2008 to 2017 with at least one outpatient visit at the in-house medical oncology service at Olten Cantonal Hospital was analysed and compared with the specific overall population-based outcome data provided by the National Agency for Cancer Registration (NACR), which were set as a national benchmark. Until 2020, no data from the Canton of Solothurn, to which Olten belongs, were reported to the NACR. Further, adherence to internationally recognized clinical guidelines for stage-specific treatment was assessed.
RESULTS: Until September 8, 2020, data on 842 patients with a median follow-up period of 70 months were collected and analysed. The 1- and 5-year overall survival for colon and non-small cell cancer, Hodgkin lymphoma, and diffuse large B-cell lymphoma and the 5-year overall survival for testicular cancer in the Olten cohort did not significantly differ from the NACR data. The 1-year overall survival for testicular cancer was not comparable statistically. The 5-year overall survival for breast cancer (unadjusted for stage) was significantly higher in the NACR collective (84.5%) than in the Olten collective (79.7%) but not for the individual breast cancer stages. The Olten collective included approximately 2.5 times as many patients with stage 4 breast cancer (17.5%) as the NACR collective (6.9%). Approximately 92.4% of the patients in the curative setting and 85.8% of the patients in the palliative setting received first-line treatment according to guidelines.
CONCLUSIONS: The statistically comparable local 1- and 5-year overall survival of the analysed malignancies, with adjustment for stage for the 5-year overall survival for breast cancer, is in line with the national benchmark. Adherence to treatment guidelines is high.
Hydraulic Sizing for Watering Green Space Application in Bechar-Algeria
Authors: Daoudi Mebarka , Guedaouria Hadja , Benmoussa Youcef , Maazouzi Abdelhak , Seddiki Karima , Mehdi Fouzia , Maammeri Hanane , Belaid Asma 
Published: July 2023

Cities with many parks and other green areas are better places to live because they attract more people, improve health and well-being, foster community, and attract tourists and investors. This paper details the detailed process of designing a drip and sprinkler irrigation network to irrigate a 300 m2 garden in a semiarid region of Algeria. Sprinkler irrigation was then performed using two models of sprinklers: the IPN-5-F, with a radius of 1.5 m, flow of 0.09 m3/h, and arc of 360°, and the IPN-12H, with a radius of 3 m. The first phase involved hydraulic sizing of the drip irrigation system for varying dripper flows, while the second addressed the use of a drip irrigation system. Drip and sprinkler irrigation have somewhat comparable watering schedules (from one for drip to 2 days for sprinkler), but drip’s flow rate is woefully inadequate when compared to sprinklers. Because of the pressure reduction provided by the manifold pipes in a drip irrigation system, it is efficient to install a single pump with a sufficient debt to service both systems.
Short-legged daddy-long-leg spiders in North America: the genera Pholcophora and Tolteca (Araneae, Pholcidae)
Authors: Huber Bernhard A. , Meng Guanliang , Valdez-Mondragón Alejandro , Král Jiří , Ávila Herrera Ivalú M. , Carvalho Leonardo S. 
Published: July 2023

The North American-Caribbean genera Pholcophora Banks, 1896 and Tolteca Huber, 2000 are representatives of Ninetinae, a group of small, cryptic, and thus poorly known pholcid spiders. We present the first comprehensive revisions of the two genera, including extensive SEM data and descriptions of seven new species from Mexico (Pholcophora mazatlan Huber sp. nov., P. papanoa Huber sp. nov., P. tehuacan Huber sp. nov., Tolteca huahua Huber sp. nov., T. manzanillo Huber sp. nov., T. oaxaca Huber sp. nov., and T. sinnombre Huber sp. nov.). We add new CO1 sequences of nine species to previously published molecular data and use these for a preliminary analysis of relationships. We recover a North American-Caribbean clade including ‘true’ (mainland) Pholcophora, Tolteca (Mexico), and a Caribbean clade consisting of the genus Papiamenta Huber, 2000 (Curaçao) and Caribbean ‘Pholcophora’. First karyotype data for Tolteca (2n♂ = 13, X1X2Y and 15, X1X2Y, respectively) reveal a strong reduction of the number of chromosome pairs within the North American-Caribbean clade, and considerable karyotype differentiation among congeners. This agrees with considerable CO1 divergence among species of Tolteca but contrasts with very inconspicuous morphological divergence. Environmental niche analyses show that the widespread P. americana Banks, 1896 (western USA, SW Canada) occupies a very different niche than its Mexican congeners and other close relatives. Caribbean taxa also have a low niche overlap with ‘true’ Pholcophora and Tolteca, supporting the idea that Caribbean ‘Pholcophora’ are taxonomically misplaced.
Prophtic Method Of Self Purification, In The Light Of Sira Tyyaba Peace And Blessings Of Allah Be Upon Him
Authors: Shabab Fatima  , Dr. Shabbir Hussain  
Published: July 2023

The Holy Prophet teaches us mental purity, spiritual maturity, improvement of intentions and maturity of character and elevation. Which has always been needed and will always be there. The Holy Prophet was an excellent psychologist, so the teachings of the Prophet(SAW) are of paramount importance in human psychology, with their help, we can solve common human disorders.The reason for the choice of this topic was to highlight the importance that the teachings of the Holy Prophet are not limited to worship alone, but a careful study of the character of the Holy Prophet reveals this fact that the Holy Prophet has given full knowledge of all the mental irritations and the principles of their remedies. Now steps should be taken to improve children's spiritual well-being and moral training, which will strengthen the positive role of the younger generation and strengthen them psychologically and mentally.Your real partner and your true identity is the person inside you. He is the one to be worshiped and He is the one who rebels. He is the one of this world and the one of the Hereafter. That inner man deserves to be rewarded and punished. decision is in your hands. Your inner self is your best friend and your worst enemy. It is a difficult journey for you and a happy destination. If the inner self is safe, then the outer self will also be safe
Pengaruh Ukuran Perusahaan, Kualitas Audit, dan Penerapan IFRS Terhadap Ketepatan Waktu Pelaporan Keuangan
Authors: Ayem Sri , Wulandari Agustina Ayu 
Published: July 2023

Latar Belakang: Laporan keuangan memiliki peran yang penting dalam pertanggungjawaban perusahaan dalam menjalankan bisnisnya. Saat menyampaikan laporan keuangan, ukuran perusahaan juga menjadi faktor yang mempengaruhi ketepatan waktu penyampaian. Semakin besar ukuran perusahaan, semakin lama waktu yang dibutuhkan untuk menghasilkan laporan keuangan, yang dapat memengaruhi ketepatan waktu penyampaian laporan keuangan
Tujuan: Penelitian ini bertujuan untuk mengevaluasi pengaruh Ukuran Perusahaan, Kualitas Audit, dan penerapan IFRS terhadap keterlambatan penyampaian laporan keuangan pada perusahaan manufaktur yang terdaftar di BEI selama periode tahun 2018-2021.
Metode: Sampel penelitian terdiri dari perusahaan manufaktur sektor makanan dan minuman yang terdaftar di Bursa Efek Indonesia selama periode 2018-2021. Teknik pengambilan sampel yang digunakan adalah teknik dokumentasi, di mana data dikumpulkan melalui studi dan penggunaan laporan keuangan yang diterbitkan oleh pihak emiten.
Hasil: Penelitian ini menunjukkan bahwa ukuran perusahaan tidak memiliki pengaruh positif terhadap ketepatan waktu penyampaian laporan keuangan. Namun, kualitas audit memiliki pengaruh positif dan signifikan terhadap ketepatan waktu penyampaian laporan keuangan. Sementara itu, penerapan IFRS tidak memiliki pengaruh yang signifikan terhadap ketepatan waktu penyampaian laporan keuangan, karena nilai data penerapan IFRS konstan atau sama.
Kesimpulan: Ukuran perusahaan dan kualitas audit memiliki dampak yang positif dan signifikan terhadap ketepatan waktu penyampaian laporan keuangan. Namun, penerapan IFRS tidak memiliki dampak yang signifikan terhadap ketepatan waktu penyampaian laporan keuangan.
Analisis Pengaruh Variasi Menu Terhadap Keputusan Pembelian di Verandah Restaurant Eastparc Hotel Yogyakarta
Authors: Sembiring Patricia Ayudia Agriffina Br , Puspadewi Roels Ni Made Sri 
Published: July 2023

Latar Belakang: Sekarang ini pariwisata termasuk dalam salah satu bisnis yang dilirik oleh orang-orang karena memiliki peluang besar. Industri pariwisata memiliki peranan cukup penting dalam membuka lapangan pekerjaan dalam suatu wilayah, dan dapat mendorong pertumbuhan ekonomi di wilayah tersebut sehingga dapat berkembang. Salah satunya yaitu adalah Eastparc Hotel Yogyakarta.
Tujuan: untuk mengetahui apakah variasi menu memiliki pengaruh terhadap keputusan pembelian pelanggan di Verandah Restaurant, Eastparc Hotel Yogyakarta.
Metode: Metode di dalam penelitian deskriptif kuantitatif dengan korelasi. Data dalam penelitian ini diperoleh dari hasil penyebaran kuesioner yang dilakukan secara online dengan menggunakan google form kepada 100 responden. Hasil kuesioner kemudian diolah dengan alat bantu berupa SPSS versi 25.
Hasil: Hasil penelitian menunjukkan berdasarkan uji Koefisien Determinasi Variasi Menu dapat menjelaskan 82,3% variabel Keputusan Pembelian, sedangkan 17,7% lainnya dipengaruhi oleh faktor lain yang tidak dijelaskan dalam penelitian ini. Berdasarkan uji regresi linear sederhana, koefisien regresi X menunjukkan angka 0,727 oleh karena itu setiap penambahan 1% pada variasi menu maka keputusan pembelian akan bertambah 0,727.
Kesimpulan: Melalui hasil uji T dapat dilihat bahwa variabel variasi menu berpengaruh signifikan terhadap keputusan pembelian.
Upaya Meningkatkan Keaktifan dan Ketuntasan Belajar Biologi Melalui Penerapan Model Note-Taking Pairs Berbantuan Log Book di SMAN 1 Juntinyuat
Authors: Astuti Weni Ermining 
Published: July 2023

Latar Belakang: Keragaman gaya belajar, tingkat kecerdasan dan daya serap peserta didik kelas XI-1 MIPA mata pelajaran biologi SMAN 1 Juntinyuat, membawa konsekuensi ketuntasan belajar cenderung timpang. Peserta didik berkemampuan akademik rendah cenderung kurang aktif, mencontek pekerjaan teman, malas bertanya, kurang bersemangat.
Tujuan: untuk mengetahui bagaimana penerapan model Note-Taking Pairs berbantuan Log Book dalam meningkatkan keaktifan dan ketuntasan belajar biologi peserta didik kelas XI-1 MIPA di SMAN 1 Juntinyuat.
Metode: Penelitian Tindakan Kelas (PTK) mengikuti sintaks Kemmis dan Taggart, meliputi tahap: 1) perencanaan (planning), 2) pelaksanaan (acting), 3) pengamatan (observing), dan 4) refleksi (reflecting). Inovasi model pembelajaran Note-Taking Pairs dengan bantuan Log Book menjadi: mengidentifikasi kemampuan akademik, membuat pasangan tim, memberikan permasalahan yang berkaitan, dan menugaskan tim untuk memecahkan masalah dan menuangkannya dalam Log Book.
Hasil: terjadi peningkatan skor keaktifan dari siklus 1 ke siklus 2, yaitu pada indikator terlibat aktif dalam menyusun catatan pembelajaran sebesar 9,1, dari 84,8% menjadi 93,9%; indikator terlibat aktif dalam menyelesaikan masalah sebesar 8,1 poin, dari 81,8% menjadi 89,9%; dan menyelesaikan tugas kelompok tepat waktu sebesar 6,1 poin dari 91,9% menjadi 85,8%. Nilai rata-rata hasil belajar sebelum tindakan 69,09, setelah tindakan naik menjadi 79,55, dan naik kembali saat UTS menjadi 85,98. Persentase ketuntasan hasil pembelajaran naik dari sebelum tindakan 45,45%, menjadi 69,70%, semakin meningkat pada tes UTS menjadi 100%. Persentase ketidaktuntasan mengalami penurunan dari 54,55%, sebelum tindakan sebesar turun menjadi 30,30% setelah tindakan siklus 1 dan 2, semakin menurun pada tes UTS menjadi 0%.
Kesimpulan: Penerapan model Note-Taking Pairs berbantuan Log Book dalam pembelajaran biologi mampu meningkatkan keaktifan dan ketuntasan belajar biologi peserta didik.
Land Rights Disputes In Cianjur Area (Decision No. 3119 K/PDT/2022)
Authors: Jesica Jesica , Djaja Benny 
Published: July 2023

Land can be granted to individuals who have been provided by the Regulation of the Minister of Agrarian Affairs and Spatial Planning/Head of the National Land Agency to be used and utilized to the best of their ability. The way to obtain land ownership rights to the land is by issuing a tangible evidence by the National Land Agency in the form of a certificate. The National Land Agency has the authority to deal with the land-related issues. One of the land disputes that frequently occurs in society is overlapping. The purpose of this research is to determine the process of resolving land pwnership disputes in the Cianjur region. The research findings indicate that the causes of overlapping are negligence of surveying officers from the Land Office or the National Land Office and the lack of public awareness among the community, especially landowners, to utilize and use their land according to the purpose of granted rights, as well as the failure to mark the boundaries of the land. This study uses normative legal research methods with a statute approach, uses secondary data types with data collection techniques, namely literature review, as well as using legal descriptive analysis
Comparison of Ultrasound-Guided Popliteal Sciatic Block Properties in Diabetic and Nondiabetic Patients
Authors: Kocayigit Havva , Şahin Fatih , Erkin Alper , Erdem Ali Fuat 
Published: July 2023

Background: We aim to share our popliteal sciatic nerve block (PSB) experience, which we applied to diabetic and nondiabetic patients in the operating room of our hospital.
Methods: The patients who underwent PSB for foot and ankle surgery between October 1, 2021, and December 31, 2021, in Sakarya University Training and Research Hospital were evaluated retrospectively. All nerve blocks were administered by a single anesthesiologist. Demographic data of the patients and the duration of the operation, the type of operation, the time of application of the nerve block, whether it was single or bifurcation block, and the onset times of motor and sensory block were also recorded in the perioperative period.
Results: It was determined that PSB was applied to 49 patients over a 3-month period. The mean age of the patients was 61.33 ± 14.03 years, and 12 patients (24.5%) were women. The reason why the patients were operated on was amputation in 21 (42.9%) and wound debridement in 27 (55.1%). There were 37 patients in the diabetic group and 12 patients in the nondiabetic group. There was no significant difference between the two groups in terms of demographic data and operation characteristics, but it was observed that there was a significant difference in both sensory and motor block formation times between the two groups (P < .001).
Conclusions: In conclusion, we think that popliteal sciatic nerve block is easy to apply, the complication rate is low, and it is a suitable anesthesia method for patients who will undergo day surgery for foot ulcer.
YouTube Videos About Plantar Fasciitis and Calcaneal Spurs Are Insufficient and Poor Quality
Authors: Yüce Ali , Ocak Olcayto , Gur Volkan , Misir Abdulhamit 
Published: July 2023

Background: Patients frequently use YouTube to learn about their illness. For this reason, the educational and quality of YouTube videos about various diseases has been investigated. In this study, we aimed to evaluate the accuracy and quality of YouTube videos.
Methods: A standard query was performed on the YouTube database using the following search terms: Plantar fasciitis, heel spur, and calcaneal spur. For each search term, the top 50 videos determined by YouTube’s “relevance” according to its algorithm were evaluated (150 videos in total). After exclusion, 140 videos were included in the study. These videos were watched by 2 observers and the videos were evaluated and scored according to the Global Quality Score (GQS), DISCERN, Journal of the American Medical Association (JAMA), and Plantar Fasciitis and Calcaneal Spurs Specific Score (PFSS) scoring systems.
Results: According to the JAMA criteria, 76.42% of the videos and 43.57% of the videos according to the GQS scored 2 points or less. According to DISCERN criteria, 67.15% of the videos were evaluated as very poor/poor. According to the PFSS, 83.5% of the videos were rated as poor or very poor.
Conclusions: These findings can be interpreted as the general information content of the videos about plantar fasciitis is insufficient and their reliability and quality are low. As a result, it can be concluded that the quality and reliability of YouTube videos regarding plantar fasciitis are insufficient for patients. Universities/associations prepare videos that provide information about plantar fasciitis to patients, and that these videos are presented on certain platforms can be a solution.