bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and Intensive Care (ICU) Service, Surge Capacity and Pandemic Training in Government Designated COVID-19 Clinics and Hospitals of Nepal
Authors: Bhattarai S. , Neopane A. K. , Shrestha B. , Dangol S. R. , Shrestha S. K. D. , Dutta A. , Adhikari G. , Dahal S. 
Published: January 2023

Background The coronavirus pandemic preparedness and response activities began in Nepal after the detection of the first case on 24 January 2020. Highest daily case record in June 2020 was 671, but it reached above 5,000 in October 2020.
Objective This study assessed preparedness and response status of government designated COVID-19 clinics and various level hospitals.
Method A web-based survey was conducted among government designated COVID-19 clinics and Level hospitals in June 2020. The Medical Operations Division of the COVID-19 Crisis Management Center (CCMC) retained contact list of focal person in each facility for regular updates. Forty-nine out of 125 clinics and all level hospitals (five Level-1, 12 Level-2, three Level-3) provided responses.
Result There were 25 or less isolation beds in the majority of COVID-19 clinics (83.7%) and Level-1 hospitals (60%), whereas the majority of Level-2 (92%) and Level-3 hospitals (67%) had arranged >25 beds. Only five clinics, one Level-1 hospital, six Level-2 and two Level-3 hospitals had a surge capacity of additional 20 or more isolation beds. Only one-fourth of the designated health facilities had arranged separate isolation facility for vulnerable population. Majority of the designated clinics and Level-1 hospitals had five or less functional ICU beds and functional ventilators. Very few Level-2 hospitals had > 10 ICU beds and > 10 ventilators. Healthcare workers in the majority of facilities were trained on donning/doffing, hand washing, swab collection, and healthcare waste management, but, a very few received formal training on patient transport, dead body management, epidemic drill, and critical care.
Conclusion This study revealed insufficient preparation in COVID-19 facilities during the initial phase of pandemic. The findings were utilized by the government stakeholders at central, provincial and local levels for scaling up surge capacity and improving health services at the time of case surge. As the pandemic itself is a dynamic process, periodic assessments are needed to gauze preparedness and response during different phases of disease outbreak.
Microbiology Learning : Based life Skills Education of Student In TADRIS Biology PRODI FATIK IAIN Kendari Through the Contextual Teaching and Learning Approach
Authors: Rosmini Rosmini , Badrianti Badrianti 
Published: January 2023

This study aims to (1) examine the life skills of students of Tadris Biology PRODI, FATIK IAIN Kendari through Microbiology learning based on Life Skills Education using the CTL Approach, (2) examining the attitudes of Tadris Biology PRODI, FATIK IAIN Kendari after learning Microbiology Based on Life Skills Education with the CTL approach. The research sample was all students of the Tadris Biology PRODI FATIK IAIN Kendari in the fifth semester of the 2018/2019 academic year totaling 32 students. The results showed that the life skills of students of the Tadris Biology PRODI at FATIK IAIN Kendari in the fifth semester of the 2018/2019 academic year through learning Microbiology with the CTL approach, all students achieved life skills competence with an average score of 8.93. Based on the results of the questionnaire, students' attitudes showed a positive attitude, meaning that students in general (85.91%) agreed to microbiology learning based on life skills education with the Cotextual Teaching and Learning Approach.
Role-Playing as a Method of Developing Social Creativity in Adolescence in an English Lesson
Authors: Sorokoumova Galina Veniaminovna , Molochnikova Yuliya Andreevna 
Published: January 2023

Introduction. The article discusses role play as one of the methods for developing social creativity in adolescence in English lesson. The article also analyses the results of the study aimed at determination of the possibility of increasing the level of students’ social creativity by implementing role plays in the educational process. Literature review. The article provides a theoretical analysis of approaches to the definition of the term «social creativity», special attention is paid to the indispensable condition for successful development of this skill – creating a special creative environment at the lesson. There is also considered the structure of a role play as a method of developing social creativity. Research methods. At the ascertaining and control stages of the study, we used the Sievert Horst test to determine creative abilities. At the formative stage, a series of lessons using role-playing games has been developed and introduced into the educational process. The results of the study. Analysis of the results of the ascertaining stage of the study allowed us to conclude that students have a low level of social creativity, are inert to proposals of new ideas, creative problem solving. The use of role plays in foreign language lessons improved the indicators on all the scales (resourcefulness, ability to combine, divergent thinking, freedom of association). Moreover the use of role plays in English lessons contributed to the development of the students’ communicative skills, improved the attitude of students to the school discipline «English», increased their motivation to study the subject. Conclusions. The results of the study allowed us to conclude that the use of role plays on the lessons of foreign language is an effective method to develop adolecents’ social creativity.
Current development status of iBNCT001, demonstrator of a LINAC-based neutron source for BNCT
Authors: Kumada Hiroaki , Li Yinuo , Yasuoka Kiyoshi , Naito Fujio , Kurihara Toshikazu , Sugimura Takashi , Sato Masaharu , Matsumoto Yoshitaka , Matsumura Akira , Sakurai Hideki , Sakae Takeji 
Published: January 2023

The iBNCT project aims to develop “iBNCT001,” a demonstration device of the linac-based neutron irradiation facility for boron neutron capture therapy (BNCT) application. iBNCT001 generates an epithermal neutron beam by irradiating 8 MeV protons accelerated by a linac onto a beryllium target. Currently, the linac can drive an average proton current of 2.1 mA. Several experiments were performed using a water phantom to confirm the main physical characteristics of the neutron beam produced at the irradiation position. The measurement results demonstrated that the maximum thermal neutron flux achievable in the phantom volume was approximately 1.36 × 10 9 cm − 2 s − 1 when a normal beam collimator with a 120 mm diameter was used. This neutron beam intensity was sufficient to complete the irradiation within 30 min using the BNCT approach. In addition to normal beam collimators, extended collimators that protrude 100 mm from the wall were developed. By using an extended collimator, it is possible to prevent interference of the patient’s body with the wall when irradiating head and neck cancers. The measurement results for the extended collimator demonstrated that irradiation with the collimator could be completed within 1 h when the neutron beam is generated with an average proton current of 2.1 mA.
The algebra of thin measurable operators is directly finite
Authors: Bikchentaev Airat 
Published: January 2023

Let $\mathcal{M}$ be a semifinite von Neumann algebra on a Hilbert space $\mathcal{H}$ equipped with a faithful normal semifinite trace $\tau$, $S(\mathcal{M},\tau)$ be the ${}^*$-algebra of all $\tau$-measurable operators. Let $S_0(\mathcal{M},\tau)$ be the ${}^*$-algebra of all $\tau$-compact operators and	$T(\mathcal{M},\tau)=S_0(\mathcal{M},\tau)+\mathbb{C}I$ be the ${}^*$-algebra of all operators $X=A+\lambda I$
with $A\in S_0(\mathcal{M},\tau)$ and $\lambda \in \mathbb{C}$. It is proved that every operator of $T(\mathcal{M},\tau)$ that is left-invertible in $T(\mathcal{M},\tau)$ is in fact invertible in $T(\mathcal{M},\tau)$.
It is a generalization of Sterling Berberian theorem (1982) on the subalgebra of thin operators in $\mathcal{B} (\mathcal{H})$.
For the singular value function $\mu(t; Q)$ of $Q=Q^2\in S(\mathcal{M},\tau)$, the inclusion $\mu(t; Q)\in \{0\}\bigcup
[1, +\infty)$ holds for all $t&gt;0$. It gives the positive answer to the question posed by Daniyar Mushtari in 2010.
Estudo de revisão sistematizada sobre biomarcadores bioquímicos de overtraining
Authors: Carneiro Tulio Oliveira , Orso Robson Silva Araujo , Gargioni Ligia Fogolin , Crisóstomo Isabella Galvão , Miguel Natanne Dias Meira , Zaccarone Júnior Augusto Carlos , Almeida Danilo de Lima , Ravagnani Priscila A. L. , Sakamoto Sabrina Ramires , Duarte Ana Cláudia Garcia de Oliveira , Fabrizzi Fernando 
Published: January 2023

No esporte a cobrança pela vitória, coloca cada vez mais o atleta profissional face a face com a busca incessante pelo desempenho tanto físico quanto tático e estratégico, visto que esses fatores são fundamentais para que se obtenha uma vitória. Entretanto, o excesso de treinamento pode às desordens danosas à saúde do atleta. Objetivo: revisão sistematizada sobre biomarcadores bioquímicos de overtraining. Utilizou-se o Checklist PRISMA para o desenvolvimento e a estratégia PICO para extração dos dados. Foram utilizados como critérios de inclusão artigos com dados primários publicados nos últimos 10 anos, em idioma português, inglês e espanhol que estivessem diretamente relacionados ao objetivo central do estudo. Resultados: Após serem utilizados todos os critérios de inclusão e exclusão, foram elegidos 11 artigos para o desenvolvimento do artigo, os quais estavam diretamente relacionados com a temática do estudo. Obteve-se nesses artigos quatro grandes classes de moléculas com potencial biomarcador de overtraining: -relacionadas ao metabolismo intermediário; - relacionadas ao perfil redox do organismo; -com função hormonal, e; -com função imunológica.
Outlook for ergometer testing with beat to beat blood pressure measurement
Authors: Tihonenko V. M. , Pivovarov V. V. , Rubinskiy A. V. , Zaitsev G. K. , Kormilitsyn A. Y. 
Published: January 2023

Objective. The article discusses the advantages of performing stress tests with pressure control at each heartbeat. The question of increasing accuracy, informativeness and safety of the test is considered. Materials and methods. We performed 30 bicycle ergometric tests with ECG measurement, beat to beat blood pressure measurement and periodic blood pressure measurement by the Korotkoff method in the shoulder. Results. It was shown that arterial pressure registered by Korotkoff sounds in the shoulder corresponded with continuous pressure at the registration moment. Because of the impossibility to measure the dynamics, the underestimation of maximum systolic arterial pressure by the Korotkoff method exceeds 20 mm Hg in every 3 tests, and exceeds 30 mm Hg in every 5 tests. Therefore, the beat to beat measurement of BP significantly improves the accuracy and informativeness value of stress tests. Conclusions. Continuous BP signal in the finger increases reliability of noisy Korotkoff sounds extraction and the results of BP measurement in the shoulder by the classical method. The increased accuracy and reliability of the measurement provides greater patient safety. Continuous pressure corrected by Korotkoff sounds during reference measurements in the shoulder gives a detailed and accurate picture of BP variations, which allows to investigate in detail features of the patient’s cardiovascular system regulation, both during and after the load, which is not available with classical BP measurement.
Influence of disinfectants on growth of biofilm formed by <i>К. pneumoniae</i> strains
Authors: Shipitsyna I. V. , Osipova E. V. 
Published: January 2023

Introduction. Currently, the problem of biofilm-associated infections is of great importance, since the classical methods of antibiotic therapy for purulent-inflammatory diseases become ineffective due to the high resistance of pathogens. An urgent task is to find ways to suppress adhesion processes or destroy an already formed biofilm using various disinfectants, enzymes, a combination of antibacterial and other drugs.Materials and methods. The object of the study is the bacteria Klebsiella pneumoniae isolated from wounds and fistulas of patients with chronic osteomyelitis. Biofilms were cultured for two days in the wells of polystyrene plates and on coverslips. In the control series of the experiment, the biofilm-forming ability of K. pneumoniae strains was studied after 48 hours. In the second series, after 24 hours, the emerging biofilm was exposed to a solution of 3 % hydrogen peroxide, in the third series, with a skin antiseptic, and after 48 hours, the intensity of biofilm formation was assessed. For statistical processing of the obtained data, the Gnumeric 1.12.17 spreadsheet program was used.Results and its discussion. K. pneumoniae strains had a high biofilm-forming ability. The impact of disinfectants on the emerging biofilm led to a decrease in the optical density in the wells of the plates and the intensity of biofilm formation. On cover slips in the second and third series of the experiment, a decrease in the total proportion of microcolonies and individual adherent cells was observed. Disinfectants (hydrogen peroxide and skin antiseptic) had a bacteriostatic effect on biofilms formed by K. pneumoniae strains. In addition, a bactericidal effect of skin antiseptic on planktonic bacterial cells was found.Conclusions. The data obtained must be taken into account for the selection of effective disinfectants used in the clinic to prevent the emergence of resistant strains of microbes.
Copolymerized carbon nitride nanoparticles for near-infrared II photoacoustic-guided synergistic photothermal/radiotherapy
Authors: Wu Min , Huang Yuxin , Huang Xiaoyu , Wang Fu , Wei Xunbin 
Published: January 2023

Nanotheranostic agents that integrate diagnosis and treatment are promising for precision medicine, but they encounter some obstacles such as penetration depth and efficiency. In this study, novel carbon nitride-rose bengal nanoparticles (CN-RB NPs) with a graphite carbon nitride skeleton were synthesized by one-step thermal copolymerization. The enhanced absorption in the near-infrared-II region (NIR-II) endows CN-RB NPs with an excellent photothermal effect under 1064 nm laser irradiation, as well as an obvious photoacoustic signal for imaging in vivo. Interestingly, due to the introduced iodine element, CN-RB NPs exhibit enhanced radiation therapy, indicating that CN-RB NPs can achieve ideal therapeutic outcome through collaborative photothermal/radiation therapy under the guidance of NIR-II photoacoustic imaging. Moreover, CN-RB NPs demonstrate minimal side effects and long-term biological stability after 14 days. Therefore, the proposed new multifunctional nano-platform CN-RB NPs hold great potential in the application of deep therapeutics.
Metagenomics next-generation sequencing provides insights into the causative pathogens from critically ill patients with pneumonia and improves treatment strategies
Authors: Liu Ying , Zhang Rui , Yao Bo , Yang Jun , Ge Huimin , Zheng Shuyun , Guo Qi , Xing Jinyan 
Published: January 2023

BackgroundThe metagenomics next-generation sequencing (mNGS) is a promising technique for pathogens diagnosis. However, whether the application of mNGS in critically ill patients with pneumonia could cause anti-infection treatment adjustment and thereby affect the prognosis of these patients has not been explored.MethodsWe retrospectively collected the clinical data of patients diagnosed with pulmonary infection in the ICU of the Affiliated Hospital of Qingdao University from January 2018 to January 2021. These patients with pneumonia were divided into mNGS group and no-mNGS group by whether being performed NGS or not. The clinical data, including demographics, illness history, APACHE II score, length of mechanical ventilation, length of stay in the hospital, length of stay in ICU and outcome, were collected. In addition, the data of pathogens and anti-infection treatment before and after NGS were also collected. Propensity score matching was performed to evaluate the mortality and deterioration rate between NGS group and non-NGS group.ResultsA total of 641 patients diagnosed with pneumonia were screened, and 94 patients were excluded based on exclusion criteria. Finally, 547 patients were enrolled, including 160 patients being performed NGS. Among these 160 patients, 142 cases had NGS-positive results. In addition, new pathogens were detected in 132 specimens by NGS, which included 82 cases with virus, 18 cases with fungus, 17 cases with bacteria, 14 cases with mycoplasma, and 1 case with mycobacterium tuberculosis. Anti-infection treatments were adjusted in some patients who performed NGS, including 48 anti-bacterial treatments, 20 antifungal treatments and 20 antiviral treatments. There were no significant differences in the mortality and deterioration rate between NGS and non-NGS group, but it exhibited a trend that the mortality and deterioration rate of NGS group was lower than non-NGS group after the propensity score matching analysis (15.8% vs 24.3%, P=0.173; 25.6% vs 37.8%, P=0.093).ConclusionNGS could affect the anti-infection treatments and had a trend of reducing the mortality and deterioration rate of critically ill patients with pneumonia.
Associations between endogenous sex hormone levels and adipokine levels in the Multi-Ethnic Study of Atherosclerosis
Authors: Varma Bhavya , Ogunmoroti Oluseye , Ndumele Chiadi E. , Kazzi Brigitte , Rodriquez Carla P. , Osibogun Olatokunbo , Allison Matthew A. , Bertoni Alain G. , Michos Erin D. 
Published: January 2023

BackgroundDifferences in sex hormone levels contribute to differences in cardiovascular disease (CVD) risk. Adipokines play a role in cardiometabolic pathways and have differing associations with CVD. Adipokine levels differ by sex; however, the association between sex hormone profiles and adipokines is not well established. We hypothesized that a more androgenic sex hormone profile would be associated with higher leptin and resistin and lower adiponectin levels among postmenopausal women, with the opposite associations in men.MethodsWe performed an analysis of 1,811 adults in the Multi-Ethnic Study of Atherosclerosis who had both sex hormones and adipokines measured an average of 2.6 years apart. Sex hormones [Testosterone (T), estradiol (E2), sex hormone binding globulin (SHBG), and dehydroepiandrosterone (DHEA)] were measured at exam 1; free T was estimated. Serum adipokines (leptin, resistin, adiponectin) were measured at exams 2 or 3. We used multivariable linear regression to examine the cross-sectional associations between sex hormones and adipokines.ResultsThe mean (SD) age was 63 (10) years, 48% were women; 59% non-White participants. For leptin, after adjusting for demographics only, higher free T and lower SHBG, were associated with higher leptin in women; this association was attenuated after further covariate adjustment. However in men, higher free T and lower SHBG were associated with greater leptin levels in fully adjusted models. For adiponectin, lower free T and higher SHBG were associated with greater adiponectin in both women and men after adjustment for CVD risk factors. For resistin, no significant association was found women, but an inverse association with total T and bioT was seen in men.ConclusionOverall, these results further suggest a more androgenic sex profile (higher free T and lower SHBG) is associated with a less favorable adipokine pattern. These findings may provide mechanistic insight into the interplay between sex hormones, adipokines, and CVD risk.
Early and dynamic detection of doxorubicin induced cardiotoxicity by myocardial contrast echocardiography combined with two-dimensional speckle tracking echocardiography in rats
Authors: Zhang Jun , Li Xin , Liu Juan , Shang Yongning , Tan Lin , Guo Yanli 
Published: January 2023

BackgroundAnthracycline-induced cardiotoxicity is well-known as a side effect of chemotherapy. Currently, clinical imaging techniques are not capable to detect doxorubicin (DOX)-induced cardiotoxicity before a functional decline. The purpose of this study was to evaluate whether myocardial contrast echocardiography (MCE) can dynamically monitor the cardiac changes in the early stage in the DOX-induced rat model of cardiotoxicity.MethodsA weekly injection of 2.5 mg/kg of DOX was used to generate a rat model of cardiotoxicity. All groups underwent ultrasonic examinations including standard echocardiography, 2D speckle tracking echocardiography (2D-STE), and MCE. Then all rats were sacrificed immediately for histopathological evaluation.ResultsA total of eight control rats and 32 DOX-treated rats were included in the study and grouped according to their treatment period. Decreased quantitative parameters of myocardial blood flow (MBF) (control vs. group 1: 133.31 ± 20.23 dB/s vs. 103.35 ± 21.60 dB/s, P = 0.048) and β (control vs. group 2: 11.17 ± 1.48/s vs. 7.15 ± 1.23/s, P &lt; 0.001) were observed after 2 and 4 weeks of treatment, respectively, while left ventricular global strain (control vs. group 3: −23.67 ± 3.92% vs. −16.01 ± 3.40%, P = 0.002) decreased after 6 weeks of treatment and left ventricular ejection fraction (LVEF) (control vs. group 4: 82.41 ± 3.20% vs. 70.89 ± 9.30%, P = 0.008) decreased after 8 weeks of treatment. The main histopathological features are increased myocardial vacuolization and interstitial fibrosis and decreased myocardial microvessel density.ConclusionCompared with standard echocardiography and 2D-STE, MCE can accurately and non-invasively detect changes in early myocardial perfusion, demonstrating the clinical potential of continuous and dynamic monitoring of DOX-induced cardiotoxicity.
A high-resolution soil moisture content analysis product in Jing-Jin-Ji using the successive correction method
Authors: Shao Changliang , Guo Yakai , Cao Yunchang , Wang Jiao 
Published: January 2023

Two soil moisture content analysis products, each with a spatial resolution of 0.0625° and a temporal resolution of 1 h from 1 October 2015 to 1 October 2021 in the Jing-Jin-Ji area, have been developed and evaluated. Using a quality control (QC) scheme based on the biweight method and a successive correction method (SCM) with different weighting functions introduced from the Cressman and/or Barnes methods, the soil moisture collected from China Land Data Assimilation System version 2.0 was taken as the background data. Two soil analysis products with induced hourly station soil observations were constructed and further compared with in situ observations and satellite products. Results show that with the biweight method, the outliers of soil moisture could be identified, and that the number of these was less than 10% of the actual reported samples. The analysis product is more accurate with the Cressman weighting function than with the Barnes as the root mean square error was reduced by 30% to 0.06, while the correlation coefficient increased by 73% to 0.59, compared to the control. These results indicate that the Cressman product is a useful and promising soil moisture data set. The proposed Cressman method is computationally simple and efficient, so the product can be easily updated to keep pace with significant increases in the volume of soil moisture data. The methods used here for QC, SCM, and comparison could help evaluate and improve land surface models and their soil moisture products.