bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiential peers cultivate a participation culture in youth justice
Authors: Brierley Andi 
Published: January 2023

PurposeThe purpose of this viewpoint paper is to explore the concept of experiential peer support, which involves individuals who have lived experiences of using care and justice services. This paper discusses whether experiential peer support can contribute to developing a participatory culture in youth justice practice.Design/methodology/approachThis viewpoint paper will critically evaluate the relational power of experiential peers. Particular attention will be paid to the key components of relational practices by reflecting on ways to enhance the voice of the child within participatory and child first approaches. The paper draws on a range of evidence and research to explore whether inclusion of a lived experience perspective can foster participatory cultures.FindingsExperiential peers can create a participatory youth justice culture, which can positively impact on desistance for justice involved children.Research limitations/implicationsFurther research needs to be undertaken to extrapolate the key characteristics of effective experiential peer support. This includes discussion on whether recruitment of wounded healers into professional youth justice roles can enhance participation in youth justice settings and construct conditions for social growth to develop in youth justice practice.Originality/valueThe author of this viewpoint paper has personal experience of care, youth incarceration and professional experience of youth justice participation practice, providing a unique vantage point and contribution to the desistance and rehabilitation literature.
Intangible cultural heritage souvenirs: image congruity and brand influence on tourists’ purchase intention
Authors: Guo Yanbing , Zhu Zhuanfa 
Published: January 2023

Purpose
Based on object–object congruity, this study aims to clarify the driving factors and antecedent mechanism of tourists’ willingness to purchase intangible cultural heritage (ICH)-souvenirs.

Design/methodology/approach
This study used a five-point Likert scale to collect data and proposed a structural equation model to explore this issue.

Findings
ICH-inheritor/souvenir-congruity is positively related to tourists’ purchase intention for ICH-souvenirs and perceived authenticity; perceived authenticity and brand identity play a chain mediating effect between ICH-inheritor/souvenir-congruity and the purchase intention for ICH-souvenirs.

Research limitations/implications
This paper excludes individual, situational and cultural factors, ignoring the possible moderating roles of these factors. This treatment simplifies the feasibility of the present study but might lead to the deviation between the results of the current research and the actual outcomes.

Practical implications
The retailers of ICH-souvenirs should encourage the ICH-inheritors to endorse and promote their products while creating. They could tell a good story about their experience or create entertainment experiences for tourists through hand-in-hand teaching.

Originality/value
This study explores the driving factors and antecedent mechanism of tourists’ purchase intention for ICH-souvenirs from the third perspective of image congruity theory, namely, object–object congruity.

Visual Abstract
Evaluation of the Amazonian fruit Ambelania acida: Chemical and nutritional studies
Authors: Corrêa Pollyane Gomes , Moura Leonardo Gomes Sanders , Amaral Ana Claudia Fernandes , Almeida Maíra Martins H. de , Souza Francisca das Chagas do Amaral , Aguiar Jaime Paiva Lopes , Aleluia Renê Lemos , Silva Jefferson Rocha de Andrade 
Published: January 2023

AbstractAmbelania acida is native to the Amazon region, with few published studies of its fruits. We examined the proximate composition of its fruits, including minerals, fatty acids, volatile organic compounds (VOCs), as well as its antioxidant capacity. The protein contents (2.61%) of the pulp and seeds (13.6%) were higher than observed in other taxa of the family or in other tropical fruits. Peel and pulp showed high contents of potassium, calcium, and magnesium, and the potassium content in the pulp was 1125 mg/100 g. The peel had higher contents of total phenolics, tannins, and ortho‐diphenols than the pulp, as well as better antioxidant activity as evidenced by 2,2′‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Power (FRAP), and Fe2+ chelating activity assays. GC‐MS analyses identified 42 VOCs in the peel and pulp, with more than 90% being classified as terpenes. Eleven types of fatty acids were identified in the lipid fractions of the peel, pulp, and seeds. Linoleic acid, an essential fatty acid for humans, was the principal fatty acid in the edible portion of the fruit, therefore, evidencing its nutritionally significant profile for the fruits when considering the relationship among polyunsaturated, saturated, and monounsaturated fatty acids. The information gathered here indicates that this native fruit is a healthy food source and its cultivation and consumption should be stimulated.
Ideological Competition
Authors: Izzo Federica , Martin Gregory J. , Callander Steven 
Published: January 2023

AbstractWe propose a model of political competition not over policy programs, but over ideologies: models of the world that organize voters' experiences and guide the inferences they draw from observed outcomes. Policy‐motivated political parties develop ideologies, and voters choose the ideology that best explains their observations. Preferences over policies are then induced by the adopted ideology. Parties thus care about winning the ideological battle as it confers an advantage in the electoral arena. We show that in equilibrium political parties always propose different models of the world. This divergence extends to all features of the environment, not just policy dimensions. A lower degree of policy extremism in the past increases the divergence on the policy dimension, thus leading to higher ideological polarization.
Viral infections in critical care: a narrative review
Authors: Conway Morris A. , Smielewska A. 
Published: January 2023

SummaryViral infections form a substantial part of the intensive care workload, even before the recent and ongoing COVID‐19 pandemic. The growing availability of molecular diagnostics for viral infections has led to increased recognition of these pathogens. This additional information, however, provides new challenges for interpretation and management. As the SARS‐CoV‐2 pandemic has amply demonstrated, the emergence and global spread of novel viruses are likely to provide continued challenges for critical care physicians into the future. This article will provide an overview of viral infections relevant to the critical care physician, discussing the diagnosis and management of respiratory viral infections, blood borne and enteric viruses. We will also discuss herpesviridae complications, commonly seen due to reactivation of latent infections. Further, we explore some rarer and emerging viruses, including recognition of viral haemorrhagic fevers, and briefly discuss post‐viral syndromes which may present to the intensive care unit. Finally, we will discuss infection control and its importance in preventing nosocomial viral transmission.
Current perspectives on maternity critical care
Authors: Cranfield K. , Horner D. , Vasco M. , Victory G. , Lucas D. N. 
Published: January 2023

SummaryMaternal critical care is a developing area of clinical practice. Looking after a critically ill woman requires a multidisciplinary team that must endeavour to maintain the relative normality of pregnancy. Whilst consideration of the fetus should be taken when making clinical decisions regarding maternal care, unfounded concerns for the fetus can contribute to therapeutic inertia such that potentially life‐saving therapies are denied to pregnant women. The management of a critically ill obstetric patient must reflect, as closely as possible, the management of critical illness outside pregnancy. We will discuss some of the current evidence and concepts around this emerging area in obstetrics, including enhanced maternity care, maternal medicine networks and clinical care.
Predictors and impact of postoperative atrial fibrillation following thoracic surgery: a state‐of‐the‐art review
Authors: Diallo E.‐H. , Brouillard P. , Raymond J.‐M. , Liberman M. , Duceppe E. , Potter B. J. 
Published: January 2023

SummaryThis review of 19 studies (39,783 patients) of atrial fibrillation after thoracic surgery addresses the pathophysiology, incidence, and consequences of atrial fibrillation in this population, as well as its prevention and management. Interestingly, atrial fibrillation was most often identified in patients not previously known to have the disease. Rhythm control with amiodarone was the most commonly used treatment and nearly all patients were discharged in sinus rhythm. Major predictors were age; male sex; history of atrial fibrillation; congestive heart failure; left atrial enlargement; elevated brain natriuretic peptide level; and the invasiveness of procedures. Overall, patients with atrial fibrillation stayed 3 days longer in hospital. We also discuss the importance of standardising research on this subject and provide recommendations that might mitigate the impact postoperative atrial fibrillation on hospital resources.
Brain development after intrauterine exposure to lithium: A magnetic resonance imaging study in school‐age children
Authors: Poels Eline M. P. , Kamperman Astrid M. , Bijma Hilmar H. , Honig Adriaan , van Kamp Inge L. , Kushner Steven A. , Hoogendijk Witte J. G. , Bergink Veerle , White Tonya 
Published: January 2023

AbstractObjectiveLithium is often continued during pregnancy to reduce the risk of perinatal mood episodes for women with bipolar disorder. However, little is known about the effect of intrauterine lithium exposure on brain development. The aim of this study was to investigate brain structure in children after intrauterine exposure to lithium.MethodsParticipants were offspring, aged 8–14 years, of women with a diagnosis of bipolar spectrum disorder. In total, 63 children participated in the study: 30 with and 33 without intrauterine exposure to lithium. Global brain volume outcomes and white matter integrity were assessed using structural MRI and diffusion tensor imaging, respectively. Primary outcomes were total brain, cortical and subcortical gray matter, cortical white matter, lateral ventricles, cerebellum, hippocampus and amygdala volumes, cortical thickness, cortical surface area and global fractional anisotropy, and mean diffusivity. To assess how our data compared to the general population, global brain volumes were compared to data from the Generation R study (N = 3243).ResultsIn our primary analyses, we found no statistically significant associations between intrauterine exposure to lithium and structural brain measures. There was a non‐significant trend toward reduced subcortical gray matter volume. Compared to the general population, lithium‐exposed children showed reduced subcortical gray and cortical white matter volumes.ConclusionWe found no differences in brain structure between lithium‐exposed and non‐lithium‐exposed children aged 8–14 years following correction for multiple testing. While a rare population to study, future and likely multi‐site studies with larger datasets are required to validate and extend these initial findings.
Optimal Sampling for Positive Only Electronic Health Record Data
Authors: Lee Seong-H. , Ma Yanyuan , Wei Ying , Chen Jinbo 
Published: January 2023

Abstract
Identifying a patient's disease/health status from electronic medical records is a frequently encountered task in electronic health records (EHR) related research, and estimation of a classification model often requires a benchmark training data with patients' known phenotype statuses. However, assessing a patient's phenotype is costly and labor intensive, hence a proper selection of EHR records as a training set is desired. We propose a procedure to tailor the best training subsample with limited sample size for a classification model, minimizing its mean-squared phenotyping/classification error (MSE). Our approach incorporates “positive only” information, an approximation of the true disease status without false alarm, when it is available. In addition, our sampling procedure is applicable for training a chosen classification model which can be misspecified. We provide theoretical justification on its optimality in terms of MSE. The performance gain from our method is illustrated through simulation and a real-data example, and is found often satisfactory under criteria beyond MSE.
The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells
Authors: Pandamooz Sareh , Jurek Benjamin , Dianatpour Mehdi , Haerteis Silke , Limm Katharina , Oefner Peter J. , Dargahi Leila , Borhani‐Haghighi Afshin , Miyan Jaleel A. , Salehi Mohammad Saied 
Published: January 2023

AbstractThe beneficial effects of hair follicle stem cells in different animal models of nervous system conditions have been extensively studied. While chick embryo extract (CEE) has been used as a growth medium supplement for these stem cells, this is the first study to show the effect of CEE on them. The rat hair follicle stem cells were isolated and supplemented with 10% fetal bovine serum plus 10% CEE. The migration rate, proliferative capacity and multipotency were evaluated along with morphometric alteration and differentiation direction. The proteome analysis of CEE content identified effective factors of CEE that probably regulate fate and function of stem cells. The CEE enhances the migration rate of stem cells from explanted bulges as well as their proliferation, likely due to activation of AP‐1 and translationally controlled tumour protein (TCTP) by thioredoxin found in CEE. The increased length of outgrowth may be the result of cyclic AMP response element binding protein (CREB) phosphorylation triggered by active CamKII contained in CEE. Further, CEE supplementation upregulates the expression of vascular endothelial growth factor (VEGF), brain‐derived neurotrophic factor and glial cell line‐derived neurotrophic factor. The elevated expression of target genes and proteins may be due to CREB, AP‐1 and c‐Myc activation in these stem cells. Given the increased transcript levels of neurotrophins, VEGF, and the expression of PDGFR‐α, S100B, MBP and SOX‐10 protein, it is possible that CEE promotes the fate of these stem cells towards Schwann cells.
Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events
Authors: Partridge Wesley , Burel Sebastien A. , Ferng Annie , Xia Shuting , Kwoh T. Jesse , Henry Scott P. , Baker Brenda F. 
Published: January 2023

AbstractThis analysis sought to assess the clinical predictivity of an in vitro assay which utilized the human B‐lymphoma BJAB cell line, for identification of antisense oligonucleotides (ASOs) with the potential to elicit innate immune activation in humans. Adverse events (AEs) from clinical trial data were analyzed based on prior clinical knowledge and network analysis of the clinical data to identify correlations with the BJAB assay. Clinically evaluated ASOs were ranked by the BJAB assay's mean log‐fold increase in TNF expression levels. Flu‐like reactions (FLRs) and injection site reactions (ISRs), were chosen as AEs of interest, along with those Medical Dictionary for Regulatory Activities preferred terms identified using AE network analysis. Fifteen different 2'‐O‐methoxyethyl (2'MOE) modified ASOs were ranked by the incidence of each AE group in the integrated safety data from 35 clinical trials. ISRs are considered to be local to the injection site, whereas FLRs are reflected by systemic constitutional symptoms. The correlations identified in this analysis of integrated clinical data provide evidence that the ASO sequences selected by the BJAB assay have a lower likelihood of causing systemic inflammatory AEs associated with FLRs, but not ISRs.
More Rights but Less Gains: Relaxed Birth Control Policy and the Loss for Women
Authors: Zhao Ying , Zhang Lin , Lu Yuanping , Wen Bo 
Published: January 2023

AbstractIn view of its aging population, China initiated in 2012 a relaxed birth control policy after a three‐decades‐long implementation of the restrictive one‐child policy. This paper examines how China's relaxed birth control policy leads to gender inequality. It specifically focuses on migrant workers because they account for a significant portion of the working group. Using the National Migrant Population Dynamic Monitoring Survey from 2014 to 2016, we found that China's two‐child pilot policy reduced female labor force participation by 1.4 percentage points. This negative effect was more pronounced for women with higher educational levels or working in the private sector because employers foresee greater risks of productivity decline. We demonstrated that the gender pay gap increased from RMB956 to RMB1,053 during this same period. Pinpointing these unintended consequences brought about by the relaxation of the one‐child policy helps provide a more complete picture of inequality and make sense of persistent relative poverty in Chinese society. To counteract gender discrimination, females are advised to work outside their home jurisdictions and take advantage of positive peer effects.
Sexual and reproductive health education for patients with myelomeningocele
Authors: Lutz Carley M. , Onwuka Amanda , Fuchs Molly E. , Carey Margaret , Griffey Judy , Hobensack Victoria L. , Sharpe Scandinaro Joanne , McCracken Kate 
Published: January 2023

AbstractAimTo evaluate the sexual and reproductive health education received by patients with myelomeningocele, the most severe form of spina bifida.MethodA survey designed to assess the sexual and reproductive health education given by a healthcare provider to patients with myelomeningocele was offered to all English‐speaking patients aged 12 years or older with a myelomeningocele clinic visit.ResultsIn total, 67 surveys were completed. Menstruation and menstrual management were discussed at a rate of 85% in females. Few patients had discussions with a provider about fertility (42%), sexuality (37%), risk of sexually transmitted infections (45%), or had a relationship with a reproductive healthcare provider (54%). Differences by sex were observed for contraceptive education. The rate of discussions increased with age. A total of 67% of female patients and 33% of male patients requested a referral to a reproductive healthcare provider.InterpretationSexual and reproductive health education is part of comprehensive care for all patients and those with disabilities should not be excluded. The lack of consistent education received by patients supports the need for increased attention to this topic. We encourage multidisciplinary myelomeningocele clinics to establish a process for delivering complete and patient‐specific sexual and reproductive health education.
Effects of sodium‐glucose cotransporter 2 inhibitors, mineralocorticoid receptor antagonists, and their combination on albuminuria in diabetic patients
Authors: Morita Ryutaro , Tsukamoto Shunichiro , Obata Shota , Yamada Takayuki , Uneda Kazushi , Uehara Tatsuki , Rehman Muhammad Ebad , Azushima Kengo , Wakui Hiromichi , Tamura Kouichi 
Published: January 2023

AbstractAimsDiabetes mellitus (DM) is the leading cause of chronic kidney disease. Albuminuria is associated with an increased risk of cardiovascular mortality. Sodium‐glucose cotransporter 2 inhibitors (SGLT2‐Is) and mineralocorticoid receptor antagonists (MRAs) protect against albuminuria; however, their combined effects on albuminuria are unclear. We performed a network meta‐analysis to investigate the effects of SGLT2‐Is, MRAs and their combination on albuminuria in type 2 DM.MethodsWe systematically searched PubMed, Medline, EMBASE and the Cochrane Library from inception up to 20 November 2022. We selected randomized control and crossover trials that compared MRAs, SGLT2‐Is, MRAs + SGLT2‐Is, or a placebo in patients with type 2 DM with a urinary albumin‐creatinine ratio (UACR) ≥30 mg/g creatinine. The primary outcome was the change in the UACR.ResultsThis meta‐analysis analysed 17 studies with 34 412 patients. The use of combination treatment with SGLT2‐Is and MRAs was associated with lower albuminuria compared with the use of SGLT2‐Is, MRAs, or the placebo alone [mean difference (95% CI): −34.19 (−27.30; −41.08), −32.25 (−24.53; −39.97) and −65.22 (−57.97; −72.47), respectively]. Treatment with SGLT2‐Is or MRAs alone caused a significant reduction in UACR compared with the placebo [mean difference (95% CI): −31.03 (−28.35; −33.72) and −32.97 (−29.68; −36.27), respectively]. The effects of MRAs on the UACR are comparable with those of SGLT2‐Is. Sensitivity analyses showed similar results.ConclusionCombination therapy with SGLT2‐Is and MRAs was associated with lower albuminuria in patients with type 2 DM compared with monotherapy with SGLT2‐Is or MRAs alone.
Hyperechoic mass of the right ventricle in adults: A rare presentation of an intracardiac teratoma
Authors: Ye Na , Wang Xiaofeng , Li Jing , Yang Shaoqing , Han Xuefang 
Published: January 2023

AbstractCardiac teratomas are very rare primary tumors; most are intrapericardial, while a few are intracardiac. Furthermore, most reported intracardiac teratomas are in the pediatric population, with few cases of secondary metastases from testicular teratomas reportedly manifesting in adults. Here, we report a rare case of a mature cystic teratoma in the right ventricle complicated by a bicuspid aortic valve (BAV) in an adult. Echocardiography and enhanced computed tomography (CT) were performed, and the mass was surgically excised. A pathological examination confirmed the diagnosis of a mature cystic teratoma. Meanwhile, mechanical valve replacement of the aortic valve was performed. No tumor recurrence or symptoms occurred in the 2‐year follow‐up. This is the first report of an adult primary intracardiac teratoma with solid hyperechoic findings on echocardiography and a BAV.