bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and genotypic drug susceptibility patterns of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Central and Southern Ethiopia
Authors: Tilahun Melaku , Wegayehu Teklu , Wondale Biniam , Gebresilase Tewdros Tariku , Gebreyohannes Tesfaye , Tekola Abraham , Alemu Mekdes , Neway Sebsib , Adnew Bethlehem , Nassir Maeruf Fetu , Kassahun Yonas , Aseffa Abraham , Bobosha Kidist 
Published: September 2023

Introduction
The persistence of tuberculosis (TB) infection in some patients after treatment has highlighted the importance of drug susceptibility testing (DST). This study aimed to determine the drug susceptibility patterns of Mycobacterium tuberculosis (M. tuberculosis) isolates from pulmonary TB (PTB) patients in Central and Southern Ethiopia.

Methods
A health institution-based cross-sectional study was conducted between July 2021 and April 2022. Sputum samples were collected from newly diagnosed smear microscopy and/or Xpert MTB/RIF-positive PTB patients. The samples were processed and cultivated in Lowenstein-Jensen (LJ) pyruvate and glycerol medium. M. tuberculosis isolates were identified using polymerase chain reaction (PCR) based region of difference 9 (RD9) deletion typing. Phenotypic DST patterns of the isolates were characterized using the BACTEC MGIT™ 960 instrument with SIRE kit. Isoniazid (INH) and Rifampicin (RIF) resistant M. tuberculosis isolates were identified using the GenoType® MTBDRplus assay.

Results
Sputum samples were collected from 350 PTB patients, 315 (90%) of which were culture-positive, and phenotypic and genotypic DST were determined for 266 and 261 isolates, respectively. Due to invalid results and missing data, 6% (16/266) of the isolates were excluded, while 94% (250/266) were included in the paired analysis. According to the findings, 14.4% (36/250) of the isolates tested positive for resistance to at least one anti-TB drug. Gene mutations were observed only in the rpoB and katG gene loci, indicating RIF and high-level INH resistance. The GenoType® MTBDRplus assay has a sensitivity of 42% and a specificity of 100% in detecting INH-resistant M. tuberculosis isolates, with a kappa value of 0.56 (95%CI: 0.36–0.76) compared to the BACTEC MGIT™ DST. The overall discordance between the two methods was 5.6% (14/250) for INH alone and 0% for RIF resistance and MDR-TB (resistance to both INH and RIF) detection.

Conclusion
This study reveals a higher prevalence of phenotypic and genotypic discordant INH-resistant M. tuberculosis isolates in the study area. The use of whole-genome sequencing (WGS) is essential for gaining a comprehensive understanding of these discrepancies within INH-resistant M. tuberculosis strains.
Parental knowledge, attitudes, and practices towards childhood fever among South-East and East Asian parents: A literature review
Authors: Ng Hoi Lam , Li Huiyuan , Jin Xiaohuan , Wong Cho Lee 
Published: September 2023

AimThe aim of this literature review was to identify, summarize, and critically appraise available empirical articles on the knowledge, attitudes, and practices towards childhood fever management among South-East and East Asian parents.DesignA literature review following PRISMA.MethodsArticles were limited to those available in the English language. Articles had to be empirical studies that used a qualitative or quantitative research design with full-text available; focus on parental knowledge, attitudes, and practices towards fever; and be published in South-East and East Asia. Searches were conducted with CINAHL, PubMed and Scopus from inception to June 2022, and eleven articles were included after removing duplicates and excluding irrelevant articles.ResultsNarrative synthesis was conducted according to four themes: source of fever information, knowledge level, attitudes, and practices towards childhood fever. Parents showed different fever knowledge needs and various information-seeking behaviors. A low level of fever knowledge was revealed in terms of temperature, fever causes, potential harms and influencing factors. South-East and East Asian parents mainly reported anxiety, concerns and fever phobia. Fever assessment methods and fever management strategies varied based on parents’ cultural background and beliefs.ConclusionsThe findings of this review highlight that inadequacy of fever knowledge and negative attitudes towards childhood fever exist in South-East and East Asian parents. Parents have diverse cultural practices during their children’s febrile episodes. However, some of them conflict with current medical guidelines, as they prioritize fever and body temperature reduction. This raises questions about their effectiveness and safety. Although some of them are medically discouraged, there are others that have been proven beneficial for the symptomatic relief of childhood fever. The results indicate an urgent need to develop a cultural-sensitive educational intervention for childhood fever management among South-East and East Asian parents. Unified educational interventions are needed to address parental concerns and fever-related knowledge needs.
Caregivers’ use of herbal and conventional medicine to treat children with sickle cell disease at Jinja Regional Referral Hospital, Eastern Uganda: A cross-sectional study
Authors: Apolot Consiliate , Obakiro Samuel Baker , Mukunya David , Olupot-Olupot Peter , Matovu Joseph K. B. 
Published: September 2023

BackgroundEvidence suggests use of herbal and conventional medicines in the treatment of Sickle Cell Disease (SCD). We examined factors associated with caregivers’ use of combined herbal and conventional medicine to treat children with SCD.MethodsA cross-sectional study was conducted at Jinja Regional Referral Hospital between January and March 2022. Caregivers of children with SCD aged 1 to 18 years attending the Sickle Cell Clinic were interviewed using structured questionnaires. We collected data on caregivers’ socio-demographic characteristics, perceptions of and intentions to use either or both therapies, self-reported use of either or both therapies and community and health-related factors. A multivariable logistic regression model was computed to assess the factors independently associated with caregivers’ use of combined therapy, using Stata version 15.0.Results372 caregivers were interviewed. On average, respondents were aged 34.3 years (Standard Deviation [SD]: ±9.8 years). 37% (n = 138) of the caregivers reported the use of both herbal and conventional medicine, 58.3% (n = 217) reported use of only conventional medicine, while 4.6% (n = 17) reported use of herbal medicine only. Higher odds of using combination therapy were found in caregivers aged 60+ years (adjusted odds ratio [AOR] = 11.8; 95% CI: 1.2, 115.2), those with lower secondary education (AOR = 6.2; 95% CI: 1.5, 26.0), those who believed in the safety of herbal medicine (AOR = 3.3; 95% CI: 1.5, 7.6) and those who thought that use of both therapies were safe (AOR = 7.7; 95% CI: 3.5, 17.0).ConclusionMore than one-third of the caregivers reported use of combined herbal and conventional medicine, most of whom were older (>60%) and had lower secondary education. There is need for targeted health promotion to educate caregivers about the dangers of using both herbal and conventional medicines in treating children with SCD.
Women empowerment domains and unmet need for contraception among married and cohabiting fecund women in Sub-Saharan Africa: A multilevel analysis based on gender role framework
Authors: Habte Aklilu , Tamene Aiggan , Bogale Biruk 
Published: September 2023

Background
Low women empowerment, is a known contributing factor to unmet needs for contraception by limiting access to health services through negative cultural beliefs and practices. However, little is known about the association between unmet needs and domains of women empowerment in Sub-Saharan African (SSA) countries. Hence, this study aimed at assessing the influence of women empowerment domains on the unmet need for contraception in the region using the most recent Demographic and Health Survey (DHS) data (2016–2021).

Methods
The data for the study was derived from the appended women’s (IR) file of eighteen SSA countries. A weighted sample of 128,939 married women was analyzed by STATA version 16. The Harvard Institute’s Gender Roles Framework, which comprised of influencer, resource, and decision-making domains was employed to identify and categorize the covariates across three levels. The effects of each predictor on the unmet need for spacing and limiting were examined using a multivariable multilevel mixed-effect multinomial logistic regression analysis. Adjusted relative risk ratio (aRRR) with its corresponding 95% confidence interval was used to declare the statistical significance of the independent variables.

Results
The pooled prevalence of unmet needs for contraception was 26.36% (95% CI: 24.83–30.40) in the region, with unmet needs for spacing and limiting being 16.74% (95% CI: 16.55, 17.02) and 9.62% (95% CI: 9.45, 12.78), respectively. Among variables in the influencer domain, educational level, family size of more than five, parity, number of children, attitude towards wife beating, and media exposure were substantially linked with an unmet need for spacing and limiting. Being in the poorest wealth quintile and enrollment in health insurance schemes, on the other hand, were the two variables in the resource domain that had a significant influence on unmet needs. The overall decision-making capacity of women was found to be the sole significant predictor of unmet needs among the covariates in the decision-making domain.

Conclusion
Unmet needs for contraception in SSA countries were found to be high. Reproductive health program planners and contraceptive service providers should place due emphasis on women who lack formal education, are from low-income families, and have large family sizes. Governments should collaborate with insurance providers to increase health insurance coverage alongside incorporating family planning within the service package to minimize out-of-pocket costs. NGOs, government bodies, and program planners should collaborate across sectors to pool resources, advocate for policies, share best practices, and coordinate initiatives to maximize the capacity of women’s decision-making autonomy.
Enhanced Recovery After Surgery (ERAS) protocols following emergency intra-abdominal surgery: A systematic review and meta-analysis protocol
Authors: McKechnie Tyler , Parpia Sameer , Bhandari Mohit , Dionne Joanna C. , Eskicioglu Cagla 
Published: September 2023

Objective
The aim of this systematic review and meta-analysis is to evaluate whether the implementation of Enhanced Recovery After Surgery (ERAS) protocols for adult patients undergoing emergency intra-abdominal surgery decreases postoperative length of stay, postoperative morbidity, and mortality compared to conventional perioperative care.

Methods
A systematic review and meta-analysis will be performed and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). It has been registered on the International Prospective Register for Systematic Reviews (PROSPERO; CRD42023391709). A comprehensive, electronic search strategy will be used to identify studies published and indexed in MEDLINE, EMBASE, Web of Science, CENTRAL, and Pubmed databases since their inception. Trial registries and references of included studies and pertinent previous systematic reviews will also be searched. Studies will be included if they are randomized controlled trials or cohort studies evaluating adult patients undergoing emergency intra-abdominal surgery and comparing ERAS or modified ERAS protocols to conventional perioperative care and report one of the following outcomes: postoperative length of stay, overall 30-day morbidity, 30-day mortality, 30-day infectious morbidity, prolonged postoperative ileus, return of bowel function, and 30-day readmissions. A meta-analysis will be performed using a random effects model for all comparative data using Cochrane Review Manager 5.3 (London, United Kingdom).

Discussion
ERAS protocols have become standard of care for patients undergoing elective surgery. Their use in the setting of emergency surgery is far less common. The aim of this systematic review and meta-analysis is to assess whether there are benefits in patient important outcomes with the implementation of ERAS protocols for patients undergoing emergency intra-abdominal surgery. Ultimately, we hope to promote their use and further large randomized controlled trials evaluating emergency surgery ERAS programs.

Prospero registration number
CRD42023391709.
Wearables for running gait analysis: A study protocol
Authors: Mason Rachel , Godfrey Alan , Barry Gillian , Stuart Samuel 
Published: September 2023

Quantitative running gait analysis is an important tool that provides beneficial outcomes to injury risk/recovery or performance assessment. Wearable devices have allowed running gait to be evaluated in any environment (i.e., laboratory or real-world settings), yet there are a plethora of different grades of devices (i.e., research-grade, commercial, or novel multi-modal) available with little information to make informed decisions on selection. This paper outlines a protocol that will examine different grades of wearables for running gait analysis in healthy individuals. Specifically, this pilot study will: 1) examine analytical validity and reliability of wearables (research-grade, commercial, high-end multimodal) within a controlled laboratory setting; 2) examine analytical validation of different grades of wearables in a real-world setting, and 3) explore clinical validation and usability of wearables for running gait analysis (e.g., injury history (previously injured, never injured), performance level (novice, elite) and relationship to meaningful outcomes). The different grades of wearable include: (1) A research-grade device, the Ax6 consists of a configurable tri-axial accelerometer and tri-axial gyroscope with variable sampling capabilities; (2) attainable (low-grade) commercial with proprietary software, the DorsaVi ViMove2 consisting of two, non-configurable IMUs modules, with a fixed sampling rate and (3) novel multimodal high-end system, the DANU Sports System that is a pair of textile socks, that contain silicone based capacitive pressure sensors, and configurable IMU modules with variable sampling rates.
Clinical trial registration: Trial registration: NCT05277181.
Risk factors for the progression to multimorbidity among UK urban working-age adults. A community cohort study
Authors: Stagg Anne L. , Harber-Aschan Lisa , Hatch Stephani L. , Fear Nicola T. , Dorrington Sarah , Madan Ira , Stevelink Sharon A. M. 
Published: September 2023

Objectives
The progression of long-term conditions (LTCs) from zero-to-one (initiation), and from one-to-many (progression)are common trajectories that impact a person’s quality of life including their ability to work. This study aimed to explore the demographic, socioeconomic, psychosocial, and health-related determinants of LTC initiation and progression, with a focus on work participation.

Methods
Data from 622 working-age adults who had completed two waves (baseline and follow-up) of the South-East London Community Health survey were analysed. Chi square tests and multinomial logistic regression were used to describe the associations between self-reported demographic, socioeconomic, psychosocial, and health-related variables, and the progression of LTCs.

Results
Small social networks, an increased number of stressful life events, low self-rated health, functional impairment, and increased somatic symptom severity were all associated with both the progression from zero-to-one LTC and from one LTC to multimorbidity (two or more LTCs). Renting accommodation (RRR 1.73 [95% CI 1.03–2.90]), smoking (RRR 1.91 [95% CI 1.16–3.14]) and being overweight (RRR 1.88 [95% CL 1.12–3.16]) were unique risk factors of developing initial LTCs, whereas low income (RRR 2.53 [95% CI 1.11–5.80]), working part-time (RRR 2.82 ([95% CL 1.12–7.10]), being unemployed (RRR 4.83 [95% CI 1.69–13.84]), and making an early work exit (RRR 16.86 [95% CI 3.99–71.30]) all increased the risk of progressing from one LTC to multimorbidity compared to being employed full-time. At follow-up, depression was the most prevalent LTC in the unemployed group whereas musculoskeletal conditions were the most prevalent in those working.

Conclusions
The journey to multimorbidity is complex, with both common and unique risk factors. Non-full-time employment was associated with an increased risk of progression to multimorbidity. Future research should explore the risk and benefit pathways between employment and progression of LTCs. Interventions to prevent progression of LTCs should include mitigation of modifiable risk factors such as social isolation.
Ramón F. Llorens García, Mónica Ruiz Bañuls y José Rovira Collado (eds.). Educación literaria y América Latina: retos en la formación lectora. Madrid: Visor Libros, 2022
Authors: Pérez-García Carmen 
Published: September 2023

Reseña de Carmen Pérez-García sobre Educación literaria y América Latina: retos en la formación lectora (Visor Libros, 2022) de Ramón F. Llorens García, Mónica Ruiz Bañuls y José Rovira Collado (eds.). 420 p. ISBN: 978-84-9895-621-4
Jangka Waktu HGB Di Atas HPL Pasca PP No 18 Tahun 2021
Authors: Alviola Bella Krisita , Silviana Ana 
Published: September 2023

AbstractThe period and arrangements regarding the procedure for extending HGB above HPL are currently regulated in PP No. 18 of 2021. Any changes in the procedure for extending the term of HGB above HPL are considered to be out of sync and harmony. The purpose of the study was to determine the arrangement of the period of HGB over HPL after the enactment of PP No. 18 of 2021 and the suitability of setting the term of HGB above HPL in PP No. 18 of 2021 with the UUPA. The results obtained from this study are firstly the regulation regarding the period of HGB over HPL which is now regulated in PP No. 18 of 2021. Second, there is no synchronization between UUPA, UUCK, and PP No. 18 of 2021.Keywords: HGB; HPL; synchronization; harmonizationAbstrakJangka waktu dan pengaturan mengenai tata cara perpanjangan HGB diatas HPL saat ini diatur dalam PP No 18 Tahun 2021. Adanya perubahan mengenai tata cara perpanjangan jangka waktu HGB diatas HPL dianggap tidak sinkron dan harmonis. Tujuan penelitian untuk mengetahui pengaturan jangka waktu HGB di atas HPL pasca berlakunya PP No 18 Tahun 2021 dan kesesuaian pengaturan jangka waktu HGB di atas HPL dalam PP No 18 Tahun 2021 dengan UUPA. Hasil yang diperoleh dari penelitian ini adalah pertama pengaturan mengenai jangka waktu HGB di atas HPL yang sekarang diatur dalam PP No 18 Tahun 2021. Kedua tidak ada sinkronisasi antara UUPA, UUCK, dan PP No 18 Tahun 2021Kata kunci: HGB; HPL; sinkronisasi; harmonisasi
“I’m not angry!”: language ideologies, misunderstanding, and marginalization among North Korean refugees in rural South Korea
Authors: Park Mi Yung 
Published: September 2023

Abstract
This qualitative study examines the language attitudes and language use of two North Korean refugees living in the Gyeongsang provincial region of South Korea and actively trying to assimilate into mainstream Korean society. In interviews, the participants expressed a hierarchical view of three varieties of Korean (their North Korean Hamgyong dialect, the South Korean Gyeongsang dialect, and standard South Korean). They discussed how their North Korean accents exacerbated their marginalization, described the Gyeongsang dialect as “ignorant” and “rude,” and explained how and why they were trying to acquire standard South Korean. They also described how their North Korean accent continued to affect their communication with local South Korean speakers, who often perceived them as sounding angry and commanding. The participants had developed diverse communicative strategies in response to these language-related challenges, including smiling so as to not appear aggressive, remaining silent to avoid being outed by their speech, speaking carefully to appear more South Korean and avoid potential misunderstandings, and proactively revealing their North Korean background and seeking their interlocutors’ understanding in advance. Based on the findings, the study offers practical implications for language-support programs designed for North Korean refugees.
Secure bootstrapping for next-gen industrial automation systems
Authors: Finster Sören , Dawoud Abdallah , Kohnhäuser Florian , Karaagac Abdulkadir 
Published: September 2023

Abstract
The digitalization of industry and the convergence of IT and OT bring about the next generation of industrial automation systems which are expected to work with an orchestration of physical and virtualized components using a single converged network. The increase of complexity in such systems must be managed by an increase in automation for orchestration and management. However, bootstrapping such a complex system from out-of-the-box components is still a manual and error-prone process. We present a bootstrapping concept that brings up a system from out-of-the-box components to an operational solution with physical and virtualized components. The concept combines incremental network discovery with secure incremental bootstrapping of discovered physical components. The gained trust in the physical components of the network is then used to translate this trust into virtualized components. By attesting the trustworthiness of hosting infrastructure, the concept allows for virtualized components to be securely assigned a cryptographically secure identity that can be used in further application onboarding. Such securely bootstrapped systems are then capable to deliver the required adaptable, modular, and secure automation solutions of the future.
Towards privacy-preserving cooperative control via encrypted distributed optimization
Authors: Binfet Philipp , Adamek Janis , Schlüter Nils , Schulze Darup Moritz 
Published: September 2023

Abstract
Cooperative control is crucial for the effective operation of dynamical multi-agent systems. Especially for distributed control schemes, it is essential to exchange data between the agents. This becomes a privacy threat if the data are sensitive. Encrypted control has shown the potential to address this risk and ensure confidentiality. However, existing approaches mainly focus on cloud-based control and distributed schemes are restrictive. In this paper, we present a novel privacy-preserving cooperative control scheme based on encrypted distributed optimization. More precisely, we focus on a secure distributed solution of a general consensus problem, which has manifold applications in cooperative control, by means of the alternating direction method of multipliers (ADMM). As a unique feature of our approach, we explicitly take into account the common situation that local decision variables contain copies of quantities associated with neighboring agents and ensure the neighbor’s privacy. We show the effectiveness of our method based on a numerical case study dealing with the formation of mobile robots.