bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF THE ROLE OF HEMOCOAGULATION DISBALANCE AS A KEY PATHOGENETIC PREDICTORS IN THE FORMATION OF SYSTEMIC DISORDERS IN EXPERIMENTAL PERITONITIS
Authors: Gutsulyuk V. G. , Savуtskyi I. V. 
Published: May 2023

Background. Peritonitis today continues to be one of the most difficult problems of both abdominal surgery and theoretical pathophysiology. One of the leading pathogenetic mechanisms of peritonitis is disorders in the hemostasis system and the development of dissemination vascular syndrome. Blockade of microcirculation caused by the development of dissemination vascular syndrome leads to tissue hypoxia and, as a result, to dysfunction of organs and body systems.
Aim: is to study changes in vascular-platelet and coagulation hemostasis under conditions of experimental fecal peritonitis in rats.
Materials and methods. Experimental studies were conducted on 24 non-linear laboratory rats, which were divided into 2 groups: 1 group – intact control (animals received distilled water), 2 group – animals of the control pathology group. According to the "Methodological recommendations for preclinical study of medicinal products", experimental peritonitis was studied on the model of V. A. Lazarenko. Indicators of vascular-platelet and coagulation hemostasis were determined according to generally accepted methods.
Results. On the first day of experimental peritonitis, a sharp increase in the rate of blood clotting and changes in the quality properties of platelets were noted, affecting their aggregation ability and retraction of an already formed blood clot. On the 4th day of the experiment, changes in the vascular-platelet link were established, indicating the exhaustion of the platelet potential, due to a decrease in blood clotting time, platelet aggregation ability, and blood clot retraction against the background of a probable increase in the number of blood platelets, which probably by now had time "get" to the bloodstream from the depot. Changes in the coagulation hemostasis system against the background of experimental fecal peritonitis indicate the development of hypercoagulation already on the first day, which is replaced by a hypocoagulation state, which indicates the exhaustion of the enzymatic systems of blood coagulation potential (as early as on the 4th day), which lasted until the end of the experiment.
Conclusion. In the development of disorders of the hemostasis system in fecal peritonitis, the key role belongs to both the internal and external mechanisms of activation of the blood coagulation system.
THE ROLE OF POST-MORTEM BIOCHEMISTRY IN THE FORENSIC MEDICAL DIAGNOSIS OF MECHANICAL INJURY (literature review)
Authors: Erhard N. , Biliakov A. 
Published: May 2023

Background. Mechanical trauma occupies one of the leading places in forensic medical examination. The main task of the expert, when conducting this kind of examination, is to provide a scientifically based answer to the questions of the pre-trial investigation bodies or the court, which relate not only to the determination of the mechanism of the injury, but also to the time period of its occurrence. Traditional methods of morphological research and methods of laboratory analyzes cannot always provide comprehensive information, especially in cases of determining the age of mechanical trauma in the early Post-mortem period. Therefore, new methods of biochemical research are being actively introduced into forensic medical practice.
Aim: Analysis of the literature devoted to the application of various biochemical diagnostic methods in forensic medical practice to establish the antiquity of mechanical trauma.
Results. In pathological conditions, such as, for example, trauma, certain molecular changes occur in the human body, which are associated with a systemic reaction to a stress factor and are manifested before the appearance of morphological changes in tissues and organs. Therefore, the use of biochemical research methods will significantly expand the possibilities of forensic diagnostics. The publication shows promising directions for the application of the biochemical method for forensic trauma diagnosis. Issues of establishing the statute of limitations for mechanical injuries are considered. Today, scientific studies of the body's stress state in cases of fatal injuries are becoming more and more common. Which is of great importance for forensic medical expert practice. Therefore, the role of manifestations of the body's systemic response to trauma is described. The role of natriuretic peptides, creatine kinase and procalcitonin in diagnosing the duration of the traumatic process is also shown.
Conclusion. The relevance and practical significance of biochemical research for the forensic diagnosis of the time of occurrence of a mechanical injury, as well as the development of new diagnostic criteria for determining the body's systemic response to trauma, necessitated a deep and comprehensive study of the above problems.
Branded Bodies: Judicial Torture, Punishment, and Infamy in Nineteenth-Century Iran
Authors: Vejdani Farzin 
Published: May 2023

<p>Forced branding, tattooing, and bodily inscriptions were linked to a complex intersection of meanings and uses in nineteenth-century Iran. Drawing on insights from studies of bodily inscriptions in other world historical contexts, this paper discusses branding as a marker of ownership, both of human slaves and of animals; Islamic attitudes toward bodily inscription and its symbolic significance in the afterlife; and associations between branding and human or divine love in Persian poetry. From this semiotic foundation, it turns to judicial uses of branding in nineteenth-century Iran: as torture for the extraction of incriminating admissions, and as punishment intended to shame (symbolically casting the criminal from society, stigmatizing their crime) and identify (tracking convicted criminals). Throughout the paper, branding’s legal place is understood in relation to silence and speaking, writing and reading, pain, humiliation, and the inversion of branding’s meaning by its victims, in Iran and a number of other societies. </p>
Waubkunii Kwe: Jack Layton Chair presents Musicians during COVID 19
Authors: Moffatt Ken 
Published: May 2023

<p>As part of the day long event Jack Layton Chair presents Musicians during COVID 19: Collaboration, Connection and Cacophony, Waubkunii Kwe shares Anishinaabe drumming and singing as well as her photos. Peformance is followed by an interview with Ken Moffatt, Jack Layton Chair, Ryerson University. First streamed on October 8, 2020. </p>
Relationships of Resistance: Stepping out of institutional constraints in education and social service
Authors: Moffatt Ken 
Published: May 2023

<p>This session focuses on the powerful forces of institutional structures as they constrain the experience of service users and the role of service providers. With this in mind, the speakers discuss the importance of resistance through relationships to make possible creative forms of caring that resist these institutional constraints. Relationships are vital to work against exclusion and to bridge access to care and education. </p>
<p>Hagit Sinai - Glazer and Sara Singh are in discussion with Esther Ignagni </p>
Forms and Acts of Resistance in Amin Maalouf’s Leo the African
Authors: NABIH ZAKARIYAE 
Published: May 2023

This article, which is entitled ‘Forms and Acts of Resistance in Amin Maalouf’s Leo the African’, is about the problematic power and resistance in a novel which is set in Islamic Spain. The idea behind this paper is that power relations, albeit lopsided, are not absolute in this novel but fluid. Not to mention that it is not unilateral as commonly thought of but--multilateral. Indeed, the setting of this Moorish novel is informed by religious and cultural tensions and the Spanish Inquisition in the Crescent and Christendom relation of power. It talks about an era prior to the epistemic and physical aggression on Moorish culture in 1492 and the failure of the Moor-Spaniard capitulación and convivencia. But since power and resistance figure immensely in this text, the analysis problematizes that relationship following the approach of the Foucauldian post-modern, positive conception of power. The object of analysis is treated as fiction, and the underlying methods are content analysis. The thesis concludes that power is fractured from within by other discourses. Besides, the problem of power and resistance is part of what is called centripetal and centrifugal dynamics: Power oscillates between two contending blocs and is, therefore, never static; these are a potion, a cocktail mix.
Mastocitoma cutáneo de alto grado diseminado en un canino: Reporte de caso
Authors: Picón Saavedra Marco Antonio , Machado Brito María Paz 
Published: May 2023

Introducción: las neoplasias cutáneas en caninos son los tumores más frecuentes en la clínica veterinaria, siendo el mastocitoma el cáncer cutáneo más común de esta especie, representando el 14 – 21 % de todos los tumores cutáneos diagnosticados en perros, y se trata de una neoplasia originada por los mastocitos. Objetivo: detalle de un caso clínico de mastocitoma cutáneo de alto grado diseminado en la ciudad de Cuenca en la Provincia del Azuay, en un paciente de especie canina, raza Yorkshire Terrier, de 6 años de edad, no castrado de 2.3kg de peso, el cual llega a consulta a la clínica Veterinaria “Patas" de la ciudad de Cuenca por presentar prurito intenso, úlceras, zonas eritematosas y nódulos firmes de aproximadamente 2 cm por 2 cm con tiempo de evolución aproximada de 2 semanas, nódulos que se encuentran en el morro, nariz, párpados, flancos, prepucio, miembros anteriores y posteriores. Metodología: esta investigación es de tipo documental y descriptiva, para lo cual se estableció una metodología de recolección de datos cronológicos del estudio de caso de mastocitoma cutáneo de alto grado diseminado en un canino, con exámenes de laboratorio e informes médicos. Resultados: se realizó una biopsia, obteniendo como resultado en el estudio histopatológico un diagnóstico presuntivo a mastocitoma de alto grado, de forma posterior se realizó la tinción especial Azul de Toluidina para el diagnóstico diferencial de linfoma cutáneo e histiocitosis reactiva cutánea, prueba que permitió confirmar el diagnóstico de caso de mastocitoma cutáneo de alto grado. Conclusiones: es importante llegar al diagnóstico definitivo mediante pruebas especiales como inmunohistoquímica o tinciones especiales como azul de toluidina, parte importante de los tratamientos es la cirugía oncológica la cual se veía muy limitada por la diseminación a nivel tegumentario del paciente.
Challenges Of a Hard of Hearing Learner in Online Language Education
Authors: KAYA Kevser , Atay Derin 
Published: May 2023

While inclusive education (IE) is embraced at the conceptual level and desired at the classroom level, successful IE implementation remains highly complex. COVID-19 (Coronavirus Disease 2019) outbreak which necessitated a quick switch to remote instruction made IE even harder to put into practice. Despite several studies regarding inclusion during face-to-face education, there has been quite limited research on online education and inclusive practices. This exploratory case study of qualitative nature took place at a state university in the southeast of Turkey with three participants: a hard of hearing (HH) English as a foreign language learner who is a freshman enrolled at the English Language Education Department and his two instructors. Data were collected by means of semi-structured interviews, journals, and narrative reports. Interviews were conducted with the student about the challenges he had and instructors’ practices during distance education, and with instructors about their general opinions towards IE and their online education practices regarding the inclusion of that student. Data were analyzed through thematic analysis. The analyses of student data revealed one major theme as “rechallenge” of an already challenging life and subthemes as nature of online education, instructors’ practices, delayed/ limited feedback, and lack of interaction. Instructors’ data revealed themes as beliefs and attitudes towards IE and need for training. Findings presented the challenges of online education for a HH pupil with significant implications, suggesting many solutions to the problems HH learners face, and raising public awareness on IE.
Багатофакторна модель підводного підриву вибухонебезпечного предмету водолазами-саперами ДСНС України
Authors: Strelets Viktor , Hrytsaienko Maksym , Soloviov Ihor , Kamyshentsev Gennady 
Published: May 2023

Мета роботи: побудова багатофакторної моделі підводного підриву вибухонебезпечного предмету (ВНП), яка повинна стати основою обґрунтування оперативно-технічних рекомендацій.
Дизайн/Метод/Підхід дослідження: застосовувались змішані методи дослідження для досягнення поставленої мети: якісний для вибору плану проведення багатофакторного експерименту; метод безпосередніх експертних оцінок для отримання та оцінки вихідних даних; кількісні для визначення параметрів моделі, перевірки достовірності та її аналізу. Перевірка достовірності під час реальних підводних підривів ВНП..
Результати дослідження: вперше отримано модель підриву ВНП у вигляді трифакторного квадратичного поліному, коефіцієнти якого встановлюють кількісний зв'язок між рівнем підготовленості особового складу, зовнішніми умовами та спорядженням рятувальників.
Теоретична цінність дослідження: набув подальшого розвитку метод обґрунтування оперативно-технічних рекомендацій рятувальникам шляхом урахування особливостей, які є властивими процесу підводного підриву ВНП.
Практична цінність дослідження: під час організації робіт з підводного підриву ВНП основну увагу треба звертати на рівень-підготовленості водолазів-саперів та умови проведення гуманітарного підводного розмінування. Також необхідно враховувати тип спорядження і ефекти взаємодії між рівнем підготовленості особового складу та умовами роботи.
Оригінальність/Цінність дослідження: вперше визначено показники, які характеризують процес підводного підриву ВНП як функціонування ерготехнічної системи «водолаз-сапер – надзвичайна ситуація, пов’язана з підводним розташуванням ВНП, який вимагає підриву на місці знаходження – спорядження особового складу». У відповідності до цих показників відбувається обґрунтування оперативно-технічних рекомендацій.
Обмеження дослідження/Майбутні дослідження: необхідність отримання нових вихідних даних для побудови нової моделі підводного підриву ВНП, у тому разі, коли водолази-сапери будуть працювати на глибині більше ніж 10 м або використовувати ребрізери. Під час подальших досліджень підвищену увагу потрібно звернути на розробку пропозицій щодо планування оперативної діяльності.
Тип статті: розрахунково-аналітичний.
Processo em saúde voltado para assistência em neonatos e crianças com doença Mieolomeningocele: uma revisão integrativa
Authors: Silva Eliandra Santos da , Melo Patricia Bezerra , Santos Tâmyssa Simões dos 
Published: May 2023

A Mielomeningocele (MMC) é uma malformação embrionária do sistema nervoso central, que ocorre nas primeiras quatro semanas de gestação. É decorrente de uma falha no fechamento do tubo neural. A Mielomeningocele é a segunda causa de deficiência do aparelho locomotor em crianças. Estudos recentes revelam a influência de grandes fatores genéticos, ambientais e nutricionais, como a deficiência de ácido fólico no início da gestação. Tem como objetivo observar as grávidas, neonatos e crianças através da literatura com o olhar atencioso com a doença Mielomenigocele. O método é uma revisão integrativa da literatura, as bases de dados utilizadas foram SciELO, LILACS e PUBMED. Após aplicação dos critérios de inclusão e exclusão, a amostra do estudo foi composta por 11 artigos, 77% deles foram publicados no ano de 2020 e 2021, onde estes estudos diferenciaram-se com o objetivo de cada artigo sendo observado com frequência entre alguns artigos a cirurgia fetal aberta para correção de Mielomeningocele (MMC). Através da realização desta revisão foi possível evidenciar na literatura a assistência de enfermagem as grávidas, neonatos e crianças através da literatura com o olhar atencioso com a doença Mielomenigocele.
El pensamiento crítico y los buenos resultados en la vida: estudio de una promoción de estudiantes del grado de educación social
Authors: García Moro Francisco José , Gomez Baya Diego , Augusto Nicoletti Javier 
Published: May 2023

La competencia crítica es necesaria para todos en nuestras sociedades multicomplejas y cambiantes como las nuestras; sin embargo, en determinados perfiles profesionales no resultaría saludable desarrollar programas de aprendizaje de dicha competencia sin el desarrollo de programa complementarios que refuercen el bienestar de dicho profesional. En el presente artículo se hace una reflexión e investigación acerca del importante papel que desempeña el pensamiento crítico en la profesión de educación social. Para ello, se hace un estudio de las creencias que una promoción de 35 educadores sociales en formación de la Universidad de Huelva tiene acerca del pensamiento crítico, de sus características, componentes y consecuencias para el propio bienestar subjetivo. Se utiliza un diseño de investigación mixto de carácter descriptivo-correlacional y cualitativo mediante análisis de contenidos de grupos focales. Ser competente críticamente para un educador social es sobrevivir a ese proceso de crítica que sin duda alguna es necesario para mejorar nuestras sociedades, sin conllevar un desgaste que termine por inhabilitar un recurso importante y fundamental para el cambio.
High-fat diet and palmitic acid amplify airway type 2 inflammation
Authors: Dimasuay Kris Genelyn , Berg Bruce , Schaunaman Niccolette , Holguin Fernando , Winnica Daniel , Chu Hong Wei 
Published: May 2023

IntroductionMetabolic dysfunction such as elevated levels of saturated fatty acids (SFA) may play a role in obese asthma, but its contribution to airway inflammation remains unclear. We sought to determine the role of high-fat diet (HFD) and palmitic acid (PA), a major form of SFA, in regulating type 2 inflammation.MethodsAirway samples from asthma patients with or without obesity, mouse models and human airway epithelial cell culture were utilized to test if SFA amplify type 2 inflammation.ResultsAsthma patients with obesity had higher levels of airway PA than asthma patients without obesity. HFD increased the levels of PA in mice, and subsequently enhanced IL-13-induced airway eosinophilic inflammation. PA treatment amplified airway eosinophilic inflammation in mice that were previously exposed to IL-13 or house dust mite. IL-13 alone or in combination with PA increased dipeptidyl peptidase 4 (DPP4) release (soluble DPP4) and/or activity in mouse airways and human airway epithelial cells. Inhibition of DPP4 activity by linagliptin in mice pre-exposed to IL-13 or both IL-13 and PA increased airway eosinophilic and neutrophilic inflammation.DiscussionOur results demonstrated the exaggerating effect of obesity or PA on airway type 2 inflammation. Up-regulation of soluble DPP4 by IL-13 and/or PA may serve as a mechanism to prevent excessive type 2 inflammation. Soluble DPP4 may have the therapeutic potential in asthma patients with obesity who have an endotype with mixed airway eosinophilic and neutrophilic inflammation.
Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis
Authors: Chen Qi , Wu Chengyuan , Wang Siwei , Wang Qiang , Wu Peiyun , Wang Lei , Yan Peiyu , Xie Ying 
Published: May 2023

Introduction: Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation. Methotrexate is one of the most effective drugs for rheumatoid arthritis, but the adverse reactions caused by oral methotrexate greatly limit its clinical application. Transdermal drug delivery system is an ideal alternative to oral methotrexate by absorbing drugs into the human body through the skin. However, methotrexate in the existing methotrexate microneedles is mostly used alone, and there are few reports of combined use with other anti-inflammatory drugs.Methods: In this study, glycyrrhizic acid was first modified onto carbon dots, and then methotrexate was loaded to construct a nano-drug delivery system with fluorescence and dual anti-inflammatory effects. Then hyaluronic acid was combined with nano-drug delivery system to prepare biodegradable soluble microneedles for transdermal drug delivery of rheumatoid arthritis. The prepared nano-drug delivery system was characterized by transmission electron microscopy, fluorescence spectroscopy, laser nanoparticle size analyzer, ultraviolet-visible absorption spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimeter and nuclear magnetic resonance spectrometer. The results showed that glycyrrhizic acid and methotrexate were successfully loaded on carbon dots, and the drug loading of methotrexate was 49.09%. The inflammatory cell model was constructed by lipopolysaccharide-induced RAW264.7 cells. In vitro cell experiments were used to explore the inhibitory effect of the constructed nano-drug delivery system on the secretion of inflammatory factors by macrophages and the cell imaging ability. The drug loading, skin penetration ability, in vitro transdermal delivery and in vivo dissolution characteristics of the prepared microneedles were investigated. The rat model of rheumatoid arthritis was induced by Freund's complete adjuvant.Results: The results of in vivo animal experiments showed that the soluble microneedles of the nano drug delivery system designed and prepared in this study could significantly inhibit the secretion of pro-inflammatory cytokines and had a significant therapeutic effect on arthritis.Discussion: The prepared glycyrrhizic acid-carbon dots-methotrexate soluble microneedle provides a feasible solution for the treatment of Rheumatoid arthritis.
Cu2In alloy-embedded ZrO2 catalysts for efficient CO2 hydrogenation to methanol: promotion of plasma modification
Authors: Song Fujiao , Gao Jia , Yang Bairen , Cao Yan , Liu Huanhuan , Xu Qi 
Published: May 2023

Cu1In2Zr4-O-C catalysts with Cu2In alloy structure were prepared by using the sol–gel method. Cu1In2Zr4-O-PC and Cu1In2Zr4-O-CP catalysts were obtained from plasma-modified Cu1In2Zr4-O-C before and after calcination, respectively. Under the conditions of reaction temperature 270°C, reaction pressure 2 MPa, CO2/H2 = 1/3, and GHSV = 12,000 mL/(g h), Cu1In2Zr4-O-PC catalyst has a high CO2 conversion of 13.3%, methanol selectivity of 74.3%, and CH3OH space-time yield of 3.26 mmol/gcat/h. The characterization results of X-ray diffraction (XRD), scanning electron microscopy (SEM), and temperature-programmed reduction chemisorption (H2-TPR) showed that the plasma-modified catalyst had a low crystallinity, small particle size, good dispersion, and excellent reduction performance, leading to a better activity and selectivity. Through plasma modification, the strong interaction between Cu and In in Cu1In2Zr4-O-CP catalyst, the shift of Cu 2p orbital binding energy to a lower position, and the decrease in reduction temperature all indicate that the reduction ability of Cu1In2Zr4-O-CP catalyst is enhanced, and the CO2 hydrogenation activity is improved.