bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Significance of Preoperative Systemic Immune Inflammation Index in Newly Diagnosed Glioblastoma Patients and the Establishment of a Nomogram
Authors: Xu Hao , Jiang Lihao , Yu Shengnan , Ren Qinglan 
Published: August 2023

Abstract
Purpose
The systemic immune inflammation index (SII) has acquired prominence as a cancer patient prognostic factor and has been utilized as an essential biomarker. Many malignant tumors' prognoses are correlated with SII, and its function in glioblastoma (GBM) is unclear. In this investigation, we sought to determine the prognostic value of SII in newly diagnosed GBM and to develop a nomogram in accordance with these findings.
Methods
The information of patients with newly operable GBM was analyzed. We identified the statistically ideal threshold values for cancer-specific death with the highest sensitivity and specificity based on Receiver Operating Characteristic Curve. To account for any potential imbalance in confounding factors, Propensity Score Matching (PSM) was utilized. Based on the findings, a nomogram was developed. The performance of the nomograms in terms of calibration, discrimination, and clinical utility was evaluated.
Results
We performed a retrospective analysis on 109 patients newly diagnosed with GBM. A lower preoperative SII (SII≤610.13) was associated with considerably longer overall survival (OS) in GBM patients, as shown by the Kaplan-Meier analysis of survival (p = 0.045). In GBM patients, using a multivariate Cox proportional hazard model, SII was found to be an independent risk factor for OS (HR=0.030, 95% CI=1.060-3.000, P=0.05). The prognosis of GBM patients could be accurately predicted using a nomogram that included SII.
Conclusion
Preoperative SII level was an independent prognostic factor for GBM patients. The nomogram including SII underscored its significance. However, further evaluation and future research are needed to validate these findings.
Synthesis and characterization of PCC from marble waste for its application in papermaking
Authors: Dhakad Vinod Kumar , Shrivastava Prashant , Agarwal Saakshy , Jana Susanta Kumar 
Published: August 2023

Abstract
CaCl2 solution and Ca(OH)2 slurry, both prepared from marble waste (MARWAS), were carbonated with CO2 gas in the presence of CTAB, SDS, Teepol-610s, Triton-X, and Tween-80 as the surface modifiers in a semi-batch foam-bed reactor (FBR) to synthesize ultrafine or submicron PCC particles with enhanced hydrophobicity. Nano/ultrafine PPC particles with and without surfactant were also synthesized in a semi-batch stirrer reactor (SR) using CaCl2 solutions made from MARWAS and NH4HCO3 as the carbonating agent by single or simultaneous application of ultrasonication (US) and surfactant, respectively. The products were characterized by SEM, TEM, XRD, FTIR, and drop shape analyzer. In the presence of SDS in the FBR, distinct and smaller hydrophobic (water contact angle of 103.3o) vaterite particles (426 nm) could be produced using CaCl2 solution than those with the Ca(OH)2 slurry. However, in the SR, methanol was found to be more effective than the aqueous solvent in synthesizing needle-like aragonite nanoparticles (215.6 nm with L/D = 8.55) from CaCl2 solution without any use of US or surfactant. Handmade papers were manufactured using ground MARWAS powder, modified and unmodified PCC. The physical, mechanical, and optical properties of these filler-loaded papers were determined. The use of surface-modified and unmodified PCC was superior to the commercial PCC in increasing filler retention, burst strength, tear strength, brightness, and opacity of the paper hand sheets. Even the direct use of MARWAS powder was found to be more effective than GCC in enhancing the optical properties, although a slight decrease in the mechanical strength was observed.
The Effectiveness of a Poly-herbal Formulation from Traditional Persian Medicine (TPM) in Gastroesophageal Reflux Disease (GERD), a Double-Blinded Randomized Clinical Trial
Authors: Ebrahimi Nazila , Fallahzadeh Abarghooee Ebrahim , Vazin Afsaneh , Ansari Ramin , Zarshenas Mohammad Mehdi 
Published: August 2023

Introduction::
Gastroesophageal reflux disease (GERD) leads to increased contact of the acidic refluxate with the esophageal mucosa. Nearly 10- 20 % of the world's population is affected by GERD. Due to the complications associated with GERD, as well as complications of long-term treatment with current medications, and global demand toward Complementary and Alternative Medicine (CAM), this study evaluated the efficacy of a poly-herbal formulation known as Mastic pill (Habb-e-Mastaki) from traditional Persian medicine (TPM), previously reformulated and standardized, in a double-blinded randomized clinical trial.

Method::
34 patients in the drug group received 4 capsules of Mastic pill plus Omeprazole capsule 20 mg daily. 34 patients in the placebo group received the same dosing of Omeprazole and placebo. The medication was given to patients for a total duration of 4 weeks. All patients were requested to fill out the modified GERD-HRQL questionnaire at the beginning and every two weeks for a total duration of six weeks.

Result::
Reflux, and heartburn severity score as well as disruption of personal life score significantly reduced in both groups, but it was more remarkable in the drug group (P-value = 0.0001). Dysphagia, early satiation, and nausea significantly reduced in the drug group while the placebo group showed no improvement. Our results suggest that constipation, bloating, belching, and odynophagia did not significantly improve in none of the groups.

Conclusion::
This study showed that Habb-e-Mastaki is effective against GERD. Further detailed in vitro and in vivo studies aimed at discovering the mechanism of action of this formulation and clinical studies involving a larger population will be necessary to explain and confirm the results obtained in the present study.
A Promising Approach of Dermal Targeting of Antipsoriatic Drugs via Engineered Nanocarriers Drug Delivery Systems for Tackling Psoriasis
Authors: Tripathi Devika , Srivastava Mansi , Rathour Krislay , Rai Awani Kumar , Wal Pranay , Sahoo Jagannath , Tiwari Ritesh Kumar , Pandey Prashant 
Published: August 2023

Abstract:Psoriasis is a complex autoimmune skin condition with a significant genetic compo-nent. It causes skin inflammation and is characterized by flaky, silvery reddish spots that can worsen with age. This condition results from an impaired immunological response of T-cells and affects 2-5% of the global population. The severity of the illness determines the choice of treat-ment. Topical treatments are commonly used to treat psoriasis, but they can have several adverse effects. Biological therapy is another option for treating specific types of psoriasis. Recently, new nanoformulations have revolutionized psoriasis treatment. Various nanocarriers, such as liposomes, nanostructured lipid nanoparticles, niosomes, and nanoemulsions, have been devel-oped and improved for drug delivery. The use of nanocarriers enhances patient compliance, pre-cise drug delivery, and drug safety. This review aims to suggest new nanocarrier-based drug de-livery systems for treating psoriasis. It discusses the importance of nanocarriers and compares them to traditional treatments. Anti-psoriatic drugs have also been investigated for cutaneous de-livery using nanocarriers. The review also covers various factors that influence dermal targeting. By highlighting several relevant aspects of psoriasis treatment, the review emphasizes the cur-rent potential of nanotechnology. Using nanocarriers as a drug delivery technique may be a promising alternative treatment for psoriasis.
A Method for Determining the Type of Human Breathing Based on Machine Learning
Authors: Zubkov A. V. , Donsckaia A. R. , Marenkov Ya. A. , Gomazkova Yu. S. , Bolgov D. A. 
Published: August 2023

The purpose of research is to increase the effectiveness of respiratory rehabilitation through the development of automated methods for determining the type of breathing based on machine learning. Methods. After the COVID-19 pandemic, respiratory rehabilitation became particularly important, as well as methods of home (remote) rehabilitation using the means provided by modern technologies, for which new methods and means began to be developed, including using wireless sensors or motion capture systems. Special attention during respiratory rehabilitation is paid to the type of human breathing, as well as automated methods for analyzing breathing. At the moment, the problem arises that most of the developed methods for analyzing breathing do not work with types of breathing: they either determine only one type, for example, diaphragmatic, or simply analyze the condition of the lungs. In this regard, there is a need to develop a method for analyzing and determining directly the types of human respiration. This article discusses three methods for solving the problem of determining the type of human breathing using a motion capture system and machine learning. The first method is based on static characteristics, for which the Random Forest model was used. The second method, which is based on time characteristics, used the Catch22 model. The third method, which determines the type of respiration using the characteristics of the sinusoid, used a composite model based on two models of Hist Gradient Boosting. Results. Three methods have been developed to determine the type of human breathing. Machine learning models were trained for each of the methods to find the best accuracy result. After conducting a comparative analysis of the developed approaches, the approach with the best accuracy is determined. Conclusion. A method for determining the type of human breathing based on machine learning has been developed, the accuracy of which is 0.81.
The Process of Managing Virtual Organizations in the Regional Economy: Problems and Directions of Development
Authors: Balaeva L. I. , Golikova G. V. 
Published: August 2023

Relevance. Virtual organizations and virtual teams are considered a response to the tightening requirements of modern business – deadlines, quality, efficiency, especially in a global environment. The pandemic has accelerated the tendency to expand the use of these structures in the country's economy as a whole, as well as at the regional level. Cooperation within the framework of the VO contributes to flexibility, efficiency, customer orientation and risk reduction. In order for virtual organizations to fully use their advantages, it is necessary to take into account that due to the specifics of such organizations in the field of PPP in the regional economy, certain additional problems may arise when managing them that are not typical for traditional organizations.The purpose of the study is to generalize, systematize and verify the problems of managing virtual organizations in the regional economy.Objectives: to substantiate the relevance of identifying and taking into account the problems of managing virtual organizations in the field of public-private partnership; to systematize the problems of managing virtual organizations noted in scientific publications; to verify the information obtained using interviews with Russian managers directly related to virtual organizations and implementing projects in the field of PPP.Methodology. During the research, the method of desk research, semi-structured interviews, as well as the method of systematization, descriptive method were used.Results: the main problems of managing virtual organizations in general and at the regional level in particular are systematized.Conclusions. Many of the problems noted for virtual organizations and teams have a common nature with "traditional" management problems, but they become more relevant due to the specific features of the organization of work. In general, the problems identified by the respondents correlate with the problems of managing virtual organizations noted in scientific publications. Taking into account the possibilities of such problems in practice and proactive management will enable virtual organizations to fully use the advantages in the field of PPP in the regional economy.
Concepts of Karl Popper, Thomas Kuhn, Imre Lakatos in the Context of the Economic Paradigm
Authors: Okorokov V. M. , Shleenko A. V. , Klikunov N. D. , Oleinikova D. G. 
Published: August 2023

Relevance. In connection with the decline of neoconservative ideology, methodological disputes have escalated regarding both the methods used by economists and the scientific paradigm underlying economic science itself. If in the XIX century economic analysis corresponded to a critical scientific approach, then in the second half of the XX century economists had to revise the requirements for the quality of research from the standpoint of falsificationism. The article deals with the problems of applying the concepts of K. Popper, I. Lakatosh, etc. Kuhn's approach to the theoretical postulates of the modern economic mainstream, Marxism and institutionalism.The purpose is to consider the problem of critical application of the concepts of K. Popper, I. Lakatosh and T. Kuhn to modern scientific knowledge and the tasks of current economic research.Objectives. The following tasks are considered: concretization of the principle of verificationism in relation to economic analysis; concretization of the principle of falsificationism in relation to economic research; determination of the directions of progressive research economic programs.Methodology. The article is prepared within the framework of the positivist paradigm and an adductive approach combining deductive-inductive logicResults. Economics is a science from the point of view of the paradigm of Imre Lakatos and Thomas Kuhn, but it is not a sphere of pure scientific knowledge from the standpoint of Karl Popper's falsificationism.Conclusions. The principle of verificationism dominates modern scientific economic research. Most economic paradigms are degrading. In economic research, it is necessary not only to strive to statistically confirm the hypothesis put forward, but also to compare it with competing scientific explanations.
Specificity of Motivation of the Main Forms of Social Participation of the Population
Authors: Vorobеva I. N. 
Published: August 2023

Relevance. In accordance with the postmodern approach, the main driving force of social change and development are the most active segments of the population, social actors. The level of activity of the population can be measured by the number of practices of its social participation, which can be divided into the following forms: formal participation in organizations, informal assistance and helping behavior. To stimulate social activity, it is necessary to study the motivation for social participation of the most active segments of the population.The purpose is reveal the essence of the motivation of social participation of the population.Objectives: measure and analyze the severity of the main practices of social participation based on the results of an empirical study; determine the determining motives for different forms of social participation.Methodology. The empirical basis of the study was a survey of residents of the city of Cherepovets, Vologda Oblast, conducted in April 2022. Results. Practices of social participation are unevenly represented in its various forms. Practices of formal participation are underdeveloped. Involved in these practices, as a rule, they are motivated for themselves, selfdevelopment, gaining new experience, knowledge, personal success, career. The practices of informal participation are more widely developed, which are most concentrated in the improvement of the urban environment, charity, and volunteer activities. The motives for changing the environment, altruistic help to people and motives for personal development are combined. The most developed practices of helping behavior, where the main motive is altruism, the desire to help others.Conclusions. The motivation for social participation has a complex multicomponent structure. The dominant motive of participation, as a rule, goes in conjunction with two or three motives from different types of motivation. The motivation of different forms of social participation differs significantly.
Optimización del pago del IVA a través de un modelo de riesgo probabilístico para la planeación financiera
Authors: Montoya José Arturo , García Cortez David Ernesto , Serrano Francisco Vargas 
Published: August 2023

<p>Las pequeñas y medianas empresas (PYMES) tienen una responsabilidad fiscal muy importante, por lo que resulta de especial interés administrar el flujo de efectivo para optimizar el pago del Impuesto al Valor Agregado. En este trabajo se propone un modelo de análisis de costo-riesgo para determinar el impacto de una estrategia de planeación fiscal que considera la intervención de una línea de crédito. Se busca tomar una decisión que logre una combinación óptima entre costos y beneficios esperados, considerando el riesgo asociado a la ocurrencia de falta de liquidez. La propuesta considera minimizar la función de impacto total, la cual se define como la suma de la función de costo y la función de riesgo. La propuesta metodológica se ilustra con datos reales de una empresa mayorista ferretera en Hermosillo, Sonora, México. Además, se llevó a cabo un estudio de simulación para mostrar la pertinencia de la propuesta.</p>
Tingkat Potensi Diri Siswa Sekolah Menengah Atas untuk Melanjutkan Studi Ke Perguruan Tinggi
Authors: Salsabila Amalia , Achmad Said Suhil , Jais Muhammad , Helmi Netti 
Published: August 2023

Rendahnya minta siswa untuk melanjutkan ke jenjang Perguruan tinggi dipengaruhi oleh potensi yang dimilikinya. Penelitian ini bertujuan untuk menganalisis tingkat potensi diri siswa sekolah menengah atas untuk melanjutkan studi ke Perguruan Tinggi. Penelitian menggunakan pendekatan kuantitatif deskriptif, dengan mengambil sampel sebesar 41 orang siswa. Data dikumpulkan dengan menggunakan angket secara daring. Angket sudah dinyatakan valid dan reliabel melalui uji coba terhadap 29 orang. Pengolahan data menggunakan statistik deskriptif. Hasil penelitian menunjukkan bahwa bahwa potensi diri untuk melanjutkan studi ke perguruan tinggi tergolong tinggi. Indikator yang paling tinggi adalah potensi spiritual, dan paling rendah potensi fisik, artinya siswa secara fisik kurang mendukung mereka untuk melanjutkan studi ke perguruan tinggi, namun potensi intelektual, potensi emosional, potensi spiritual, potensi ketahanmalangan dan potensi sosial sangat sangat mendukung. Dengan demikian, potensi siswa cukup kuat untuk melanjutkan karena kemampuan dan kekuatan yang dimiliki oleh seseorang baik fisik maupun mental akan memberikan kemungkinan seseorang berhasil karena potensi diri adalah kekuatan diri yang harus diwujudkan secara maksimal.
Multimedia Interaktif Berbasis Pendekatan Saintifik Efektif Meningkatkan Kompetensi Pengetahuan IPA
Authors: Dharmayani Ni Putu Ayu Gayatri , Agung Anak Agung Gede , Wiyasa I Komang Ngurah 
Published: August 2023

Belum tersedianya media pembelajaran yang efektif dan inovatif dalam pembelajaran IPA di sekolah. Pembelajaran hanya mengandalkan buku membuat siswa kurang antusias dalam belajar. Penelitian ini bertujuan menciptakan multimedia interaktif berbasis pendekatan saintifik materi Perkembangbiakan Tumbuhan dan Hewan kelas VI SD. Penelitian pengembangan ini menggunakan model pengembangan ADDIE. Subjek penelitian, yaitu: ahli rancang bangun, ahli isi pembelajaran, ahli desain instruksional, ahli media pembelajaran, dan 17 siswa kelas VI SD. Metode pengumpulan data menggunakan angket dan tes. Teknik analisis data menggunakan deskriptif kuantitatif, kualitatif dan statistik inferensial teknik uji-t. Hasil penelitian yaitu validasi dari para ahli mendapatkan skor rata-rata 88,10% kualifikasi baik, uji coba perorangan sebesar 92,36% kualifikasi sangat baik, dan uji coba kelompok kecil sebesar 97,92% kualifikasi sangat baik. Hasil uji efektivitas dengan uji-t ada perbedaan yang signifikan kompetensi pengetahuan muatan IPA materi perkembangbiakan tumbuhan dan hewan setelah menggunakan multimedia interaktif berbasis pendekatan saintifik. Disimpulkan multimedia interaktif berbasis pendekatan saintifik dinyatakan layak untuk digunakan dalam pembelajaran dan efektif meningkatkan kompetensi pengetahuan IPA siswa kelas VI SD. Implikasi penelitian ini adalah memotivasi guru untuk menggunakan media pembelajaran sebagai variasi untuk menciptakan suasana belajar yang menyenangkan.
Multimedia Interaktif Berbasis Aplikasi Adobe Flash CS6 pada Pembelajaran Tematik
Authors: Budi Sentot Setia , Miaz Yalvema 
Published: August 2023

Pembelajaran yang dilaksanakan masih konvensional dan tidak menggunakan media pembelajaran yang bervariasi. Siswa tidak terlibat aktif dalam pembelajaran menyebabkan suasana belajar yang kurang. Ditemukan siswa masih sering mengobrol yang tidak berkaitan dengan pembelajaran, sering mengganggu temannya, serta sering izin keluar kelas. Penelitian ini bertujuan untuk menciptakan multimedia interaktif berbasis aplikasi adobe flash cs6 pada pembelajaran tematik di kelas V SD. Jenis penelitian ini yaitu research and development (R&D) dengan model pengembangan 4D. Metode yang dipakai untuk mengumpulkan data penelitian adalah observasi, wawancara, dan kuesioner atau angket. Instrument pengumpulan data menggunakan kuesioner. Subjek validasi dilakukan oleh beberapa ahli, yakni 2 ahli materi, dan satu orang praktisi atau guru, 1 ahli bahasa 1, ahli media. Subjek uji coba adalah siswa kelas V SD yang berjumlah 22 orang. Teknik analisis data menggunakan analisis deskriptif kualitatif dan kuantitatif. Hasil analisis yaitu hasil penilaian dari ahli materi 92% dan ahli bahasa 94% dengan kriteria keduanya sangat baik. Hasil penilaian dari ahli media 81% dengan kriteria baik. Hasil uji coba terhadap siswa di kedua sekolah adalah 92% dan 94% dengan kriteria keduanya adalah sangat baik. Disimpulkan, produk yang dihasilkan layak digunakan pada pembelajaran tematik di kelas V SD.
QUICK RESPONSE CODE (QR CODE) ASSISTANCE IN REALIZING THE DIGITALIZATION OF PUBLIC SERVICES AT THE RELIGIOUS AFFAIRS OFFICE OF THE PELAYANGAN SUB-DISTRICT OF JAMBI CITY
Authors: Sayuti  , Qibtiyah Mariatul , Hasan Hadri , Sibawaihi Muhammad , Nasbah  
Published: August 2023

This article is the result of Community Service (PkM) at the Office of Religious Affairs (KUA) Pelayangan District, Jambi City. KUA Pelayangan as one of the public service agencies must be able to provide public servants, especially digital public services, which at this time have become a necessity for people in the digital era. One alternative form of service digitization is by applying the Quick Responses Code (QR Code). The PkM team provided assistance to Pelayangan KUA employees to utilize the QR Code in serving the community. By using the Asset Based Community Development (ABCD) method which has the principle that everything leads to the context of understanding and internalizing assets, potential, strength and utilization independently and maximally. The process of implementing this service activity is carried out by observation, socialization, discussion, mentoring, monitoring and evaluation. The results of this PkM program assistance show that KUA employees, as potential human resources, are able to adapt well to understand and even apply the QR Code in services. Not only the KUA, the community also gave a positive response to the use of QR Code in the current digital era.