bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual communities of practice as responses to the turbulence of 2020: developing equity and justice leadership
Authors: Bornstein Joshua , Gil Elizabeth 
Published: August 2023

PurposeVirtual communities of practice (VCoPs) supported educators during the COVID-19 pandemic and the resurgent movement for racial justice that arose in 2020. Four VCoPs offered a venue for practitioners and researchers to develop social capital in the face of pandemic and persistent institutional racism.Design/methodology/approachResearchers conducted semi-structured interviews with organizers of four VCoPs and collected supporting documentation from those organizers.FindingsVCoP organizers created opportunities to develop bridging and bonding capital of equity- and justice-focused educators.Research limitations/implicationsThe analysis points toward the affordances of VCoPs in crisis response and equity leadership.Originality/valueThis original analysis extends work on communities of practice, generally, virtual communities of practice, and equity leadership development.
The persuasive effect of humorous prompts on tourists’ heritage responsible behaviors
Authors: Ji Jia-Cheng , Li Yong-Quan , Ruan Wen-Qi , Zhang Shu-Ning , Deng Fang 
Published: August 2023

Purpose
This paper aims to elucidate how humorous prompts affect tourists’ heritage responsible behaviors (THRBs).

Design/methodology/approach
Three scenario-based experiments were conducted through Credamo (an online survey platform). Studies 1 and 2 used a single-factor (language style: humorous vs serious) between-subject design to test the direct and indirect effects of humorous prompts. Study 3 used a 2 (environmental quality: high vs low) × 2 (language style: humorous vs serious) between-subject design to further reveal the boundary condition (environmental quality) of the humor effect.

Findings
The results revealed that humorous (vs serious) prompts better persuade tourists to engage in heritage responsible behaviors (HRBs). Content liking mediates the relationship between humorous prompts and THRBs. Moreover, environmental quality significantly moderates the effect of humorous prompts on THRBs, whereby the persuasive effect of humorous prompts is greater in high environmental quality conditions than in low environmental quality conditions.

Practical implications
Destination management organizations can use humor to reduce tourists’ reactance against prompts for behavioral persuasion. Moreover, it is also important to adapt humorous prompts to changes in environmental quality in a timely manner.

Originality/value
Based on psychological reactance theory, the research confirmed the dominant effect of humorous prompts by using content liking as a mediating variable, providing a new research perspective for research on the regulation of THRBs. Moreover, the authors clarified a boundary condition for the persuasiveness of humorous prompts, which helps reinforce the comprehension of humor persuasion.
Resource‐efficiency actions and financial performance: Exploring the moderating role of production cost
Authors: Ahmad Muhammad Ishfaq , Naseem Muhammad Akram , Battisti Enrico , Rehman Ramiz Ur , Giovando Guido 
Published: August 2023

AbstractThis study employs the Porter hypothesis framework to test the moderating role of production cost in the relationship between resource‐efficiency actions and financial performance for German small and medium‐sized enterprises (SMEs). For this purpose, we employ the 2012, 2018, and 2021 Flash Eurobarometer surveys to analyze how consistently SMEs adopt resource‐efficiency actions, and the impact of these actions on their performance and costs. We also conduct a generalized method of moments regression analysis (GMM). Among the seven resource‐efficiency actions proposed, saving water had a significant positive (negative) influence on financial performance in 2012, 2021, and (2018). Saving energy and using renewable energy had a positive and significant (insignificant) effect on financial performance in 2018, 2021, and (2012). Finally, selling scrap material to other companies had a positive and significant impact in all years. Furthermore, increased production costs negatively moderate the relationship between eco‐efficiency action scores and financial performance. The results indicate that the “strong” version of the Porter hypothesis is not supported: It only holds when the implementation of eco‐efficiency actions reduces production costs and increases financial performance.
Predicting obstruction risk using common ultrasonography parameters in paediatric hydronephrosis with machine learning
Authors: Khondker Adree , Kwong Jethro C. C. , Chancy Margarita , D'Souza Neeta , Kim Kellie , Kim Jin K. , Tse Lai Nam , Chua Michael , Yadav Priyank , Erdman Lauren , Weaver John , Lorenzo Armando J. , Rickard Mandy 
Published: August 2023

ObjectiveTo sensitively predict the risk of renal obstruction on diuretic renography using routine reported ultrasonography (US) findings, coupled with machine learning approaches, and determine safe criteria for deferral of diuretic renography.Patients and MethodsPatients from two institutions with isolated hydronephrosis who underwent a diuretic renogram within 3 months following renal US were included. Age, sex, and routinely reported US findings (laterality, kidney length, anteroposterior diameter, Society for Fetal Urology [SFU] grade) were abstracted. The drainage half‐times were collected from renography and stratified as low risk (<20 min, primary outcome), intermediate risk (20–60 min), and high risk of obstruction (>60 min). A random Forest model was trained to classify obstruction risk, here named the ‘Artificial intelligence Evaluation of Renogram Obstruction’ (AERO). Model performance was determined by measuring area under the receiver‐operating‐characteristic curve (AUROC) and decision curve analysis.ResultsA total of 304 patients met the inclusion criteria, with a median (interquartile range) age of diuretic renogram at 4 (2–7) months. Of all patients, 48 (16%) were low risk, 102 (33%) were intermediate risk, 156 (51%) were high risk of obstruction based on diuretic renogram. The AERO achieved a binary AUROC of 0.84, multi‐class AUROC of 0.74 that was superior to the SFU grade, and external validation (n = 64) binary AUROC of 0.76. The most important features for prediction included age, anteroposterior diameter, and SFU grade. We deployed our application in an easy‐to‐use application (https://sickkidsurology.shinyapps.io/AERO/). At a threshold probability of 30%, the AERO would allow 66 more patients per 1000 to safely avoid a renogram without missing significant obstruction compared to a strategy in which a renogram is routinely performed for SFU Grade ≥3.ConclusionsCoupled with machine learning, routine US findings can improve the criteria to determine in which children with isolated hydronephrosis a diuretic renogram can be safely avoided. Further optimisation and validation are required prior to implementation into clinical practice.
“It hits me in the weirdest moments”: How future female workers experience loss in times of planetary crisis
Authors: Kishik Sharon , Pors Justine Grønbæk 
Published: August 2023

AbstractThis paper explores how looming planetary crises become present in the lived experiences of future female workers, and how such experiences condition performances of viable subjectivity. Drawing on interview data from a longitudinal study of young women's education and career aspirations, the paper zooms in on moments where concerns about planetary crises were felt in informants' everyday lives. We augment Judith Butler's writings on loss with Karen Barad's concept of “intra‐action” to theorize these moments as experiences of loss in which constitutive dependencies and entanglements—otherwise repressed and invisible—touch young women's lives. Against this theoretical backdrop, we trace how such experiences interrupt performances of neoliberal work subjectivity and thereby create a potential for alternative agencies grounded in an ethics of entanglement. The paper thus contributes new insights into young women's complex performances of viable work subjectivity, showing how more sustainable and collective ways of performing the self emerge. As such, we offer researchers and professionals working with and around young women a nuanced understanding of how young women contest and exceed notions of neoliberal individualism.
Current magnetic resonance imaging‐based diagnostic strategies for prostate cancer
Authors: Inoue Toru , Shin Toshitaka 
Published: August 2023

AbstractRecent developments in multiparametric MRI and MRI‐targeted biopsy have made it possible to detect clinically significant cancers more accurately and efficiently than ever before. Furthermore, software that enables easy MRI/US image fusion has been developed and is already available on the market, and this has provided a tailwind for the spread of MRI‐based prostate cancer diagnostic strategies. Such precise diagnosis of prostate cancer localization is essential for highly accurate focal therapy. In addition, a recent large‐scale study applying MRI to community screening for prostate cancer has reported its usefulness. By contrast, concerns about overdiagnosis and overtreatment, the existence of inter‐reader variability in MRI diagnosis, and issues with current MRI‐targeted biopsy have emerged. In this article, we review the development of multiparametric MRI and MRI‐targeted biopsy to date and the current issues and discuss future directions.
Why history matters for moral responsibility: Evaluating history‐sensitive structuralism
Authors: Cyr Taylor W. 
Published: August 2023

AbstractIs moral responsibility essentially historical, or does an agent's moral responsibility for an action depend only on their psychological structure at that time? In previous work, I have argued that the two main (non‐skeptical) views on moral responsibility and agents’ histories—historicism and standard structuralism—are vulnerable to objections that are avoided by a third option, namely history‐sensitive structuralism. In this paper, I develop this view in greater detail and evaluate the view by comparing it with its three dialectical rivals: skepticism about moral responsibility, historicism, and standard structuralism. Each comparison includes discussion of new work on moral responsibility and agents’ histories, and along the way I offer new arguments for preferring history‐sensitive structuralism, paying special attention to the view's explanatory power.
Do We Collaborate With What We Design?
Authors: Evans Katie D. , Robbins Scott A. , Bryson Joanna J. 
Published: August 2023

AbstractThe use of terms like “collaboration” and “co‐workers” to describe interactions between human beings and certain artificial intelligence (AI) systems has gained significant traction in recent years. Yet, it remains an open question whether such anthropomorphic metaphors provide either a fertile or even a purely innocuous lens through which to conceptualize designed commercial products. Rather, a respect for human dignity and the principle of transparency may require us to draw a sharp distinction between real and faux peers. At the heart of the concept of collaboration lies the assumption that the collaborating parties are (or behave as if they are) of similar status: two agents capable of comparable forms of intentional action, moral agency, or moral responsibility. In application to current AI systems, this not only seems to fail ontologically but also from a socio‐political perspective. AI in the workplace is primarily an extension of capital, not of labor, and the AI “co‐workers” of most individuals will likely be owned and operated by their employer. In this paper, we critically assess both the accuracy and desirability of using the term “collaboration” to describe interactions between humans and AI systems. We begin by proposing an alternative ontology of human–machine interaction, one which features not two equivalently autonomous agents, but rather one machine that exists in a relationship of heteronomy to one or more human agents. In this sense, while the machine may have a significant degree of independence concerning the means by which it achieves its ends, the ends themselves are always chosen by at least one human agent, whose interests may differ from those of the individuals interacting with the machine. We finally consider the motivations and risks inherent to the continued use of the term “collaboration,” exploring its strained relation to the concept of transparency, and consequences for the future of work.
Potential Use of Polyvinyl Alcohol as an Effective Inclusion Vehicle of Thermally Reduced Graphene Oxides in Nanoreinforced Aluminum Matrix Composites
Authors: Pava Andres Felipe , Garcia Mateo Duarte , Herrera Sara N. , Meza Juan M. , Herrera Ramirez Jose Martin , Isaza M. Cesar A. 
Published: August 2023

Abstract
Polyvinyl alcohol (PVA) was investigated as a vehicle for incorporating thermally reduced graphene oxides (TRGOs) into metal matrix composites (MMCs). The TRGOs were synthesized using the modified Hummers’ method and characterized using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The PVA/TRGOs nanocomposites were synthesized using the solution mixing technique. The dispersion qualification and quantification of TRGOs in PVA were evaluated through tension and nanoindentation tests, as well as elastic modulus mapping by nanoindentation. The results demonstrated a good dispersion of TRGOs in the PVA matrix, resulting in exceptional mechanical properties. The dispersion time and energy variables were carefully controlled, leading to a good dispersion degree verified by the quantification analysis. Furthermore, preliminary studies confirmed the effectiveness of the PVA as an inclusion vehicle for nanoreinforcements in metallic matrices.
Ehrlichia
Notch signaling induction promotes XIAP stability and inhibits apoptosis
Authors: Patterson LaNisha L. , Byerly Caitlan D. , Solomon Regina , Pittner Nicholas , Bui Duc Cuong , Patel Jignesh , McBride Jere W. 
Published: August 2023

ABSTRACT

Ehrlichia chaffeensis
has evolved multiple strategies to evade innate defenses of the mononuclear phagocyte. Recently, we reported the
E. chaffeensis
tandem repeat protein (TRP)120 effector functions as a Notch ligand mimetic and a ubiquitin ligase that degrades the nuclear tumor suppressor, F-box and WD repeat domain-containing 7, a negative regulator of Notch. The Notch intracellular domain (NICD) is known to inhibit apoptosis primarily by interacting with X-linked inhibitor of apoptosis
p
rotein (XIAP) to prevent degradation. In this study, we determined that
E. chaffeensis
activation of Notch signaling increases XIAP levels, thereby inhibiting apoptosis through both the intrinsic and executioner pathways. Increased NICD and XIAP levels were detected during
E. chaffeensis
infection and after TRP120 Notch ligand mimetic peptide treatment. Conversely, XIAP levels were reduced in the presence of Notch inhibitor DAPT. Cytoplasmic and nuclear colocalization of NICD and XIAP was observed during infection and a direct interaction was confirmed by co-immunoprecipitation. Procaspase levels increased temporally during infection, consistent with increased XIAP levels; however, knockdown (KD) of XIAP during infection significantly increased apoptosis and Caspase-3, -7, and -9 levels. Furthermore, treatment with SM-164, a second mitochondrial activator of caspases (Smac/DIABLO) antagonist, resulted in decreased procaspase levels and increased caspase activation, induced apoptosis, and significantly decreased infection. In addition, RNAi KD of XIAP also decreased infection and significantly increased apoptosis. Moreover, ectopic expression of TRP120 HECT Ub ligase catalytically defective mutant in HeLa cells decreased NICD and XIAP levels and increased caspase activation compared to HeLa cells with functional HECT Ub ligase catalytic activity (TRP120-WT). This investigation reveals a mechanism whereby
E. chaffeensis
modulates Notch signaling to stabilize XIAP and inhibit apoptosis.
Species- and strain-specific differences in the phagocytosis of
Prototheca
: insights from live-cell imaging
Authors: Haider Mohammed J. A. , Shave Christopher D. , Onyishi Chinaemerem U. , Jagielski Tomasz , Lara-Reyna Samuel , Frickel Eva-Maria , May Robin C. 
Published: August 2023

ABSTRACT

The genus
Prototheca
is an extremely unusual group of achlorophyllic, obligately heterotrophic algae. Six species have been identified as pathogens of vertebrates, including cattle and humans. In cattle,
P. bovis
is the main infectious pathogen and is associated with bovine mastitis. In contrast, human infections typically involve
P. wickerhamii
and are associated with a spectrum of varying clinical presentations.
Prototheca
spp. enter the host from the environment and are therefore likely to be initially recognized by cells of the innate immune system. However, little is known about the nature of the interaction between
Prototheca
spp. and host phagocytes. In the present study, we adopt a live-cell imaging approach to investigate these interactions over time. Using environmental and clinical strains, we show that
P. bovis
cells are readily internalized and processed by macrophages, whereas these immune cells struggle to internalize
P. wickerhamii
. Serum opsonization of
P. wickerhamii
only marginally improves phagocytosis, suggesting that this species (but not
P. bovis
) may have evolved mechanisms to evade phagocytosis. Furthermore, we show that inhibition of the kinases Syk or PI3K, which are both critical for innate immune signaling, drastically reduces the uptake of
P. bovis
. Finally, we show that genetic ablation of MyD88, a signaling adaptor critical for Toll-like receptor signaling, has little impact on uptake but significantly prolongs phagosome maturation once
P. bovis
is internalized. Together, our data suggest that these two pathogenic
Prototheca
spp. have very different host-pathogen interactions which have potential therapeutic implications for the treatment of human and animal disease.
Whole-genome sequencing of
Salmonella pullorum
and Sanguinarine-induced mutant
Authors: Chen Huahai , Li Zongyan , Hou Aijie , Yin Yeshi 
Published: August 2023

ABSTRACT

This work was performed on commercially purchased
Salmonella pullorum
CVCC519 originally isolated from chicken intestinal content. The Sanguinarine-resistant strain XM3104 was isolated from Sanguinarine-induced CVCC519. To identify possible mechanisms underlying resistance, the complete genomes of CVCC519 and XM3104 were sequenced using PromethION and next-generation sequencing.
Draft genome sequence of
Streptomyces
sp. strain ICN988, isolated from
Gorgonia
sp.
Authors: Nallathambi Sangeetha , Sam Albert Joshua , Vincent Samuel Gnana Prakash 
Published: August 2023

ABSTRACT

This study elucidates the draft genomic sequence of
Streptomyces
sp. strain ICN988, an actinomycete isolated from
Gorgonia
. The assembled genome consists of 6,122,654 bp with a GC content of 73%. A comprehensive analysis revealed 19 biosynthetic gene clusters.
First Results of Stratigraphic Drilling in the East Siberian Sea Focused on Geological Studies of the Suture Zone of the Continental Shelf’s Marginal Structures and Deep-Water Areas of the Arctic Ocean
Authors: Petrov O. V. , Nikishin A. M. , Petrov E. I. , Tatarinov V. Yu. , Kashubin S. N. , Prishchepenko D. V. , Malyshev N. A. , Danilkin S. M. , Verzhbitsky V. E. , Kolyubakin A. A. , Komissarov D. K. , Stavitskaya V. N. , Shurekova O. V. , Razumkova E. S. , Tolmacheva T. Yu. , Leontiev D. I. , Tokarev M. Yu. , Ponimaskin A. I. , Zamotina Z. S. 
Published: August 2023

Abstract
A shallow well was drilled in the East Siberian Sea for the first time with the purpose of geological study of the suture zone of deep waters of the Arctic Ocean and marginal structures of the continental shelf. The works have been carried out at the initiative of the Federal Agency on Mineral Resources (Rosnedra) in August 2022. The well was drilled by the Russian Geological Research Institute (VSEGEI) and Rosgeologia with the assistance of Rosneft and was linked to the Rosneft’s long-term stratigraphic drilling program. Drilling was accompanied by continuous seismic-acoustic profiling and well thermometry. The maximum depth of the well was 472 m from the bottom of the sea floor; 147.5 m of core was taken to a depth of 268 m. Two sedimentary sequences were identified in the section: the Lower Jurassic–Lower Cretaceous gently deformed sequence and the Upper Neogene–Quaternary horizontally lying sequence. The sequences are separated by a thick unsampled interval with horizons of confined waters. The Jurassic–Lower Cretaceous sequence composes a northwestern-dipping monocline broken by faults and probably belongs to the complex filling the Zhokhov marginal trough of the Verkhoyansk–Chukotka orogen on the Eastern Arctic shelf.
Dietary wheat amylase trypsin inhibitors exacerbate CNS inflammation in experimental multiple sclerosis
Authors: Zevallos Victor F , Yogev Nir , Hauptmann Judith , Nikolaev Alexei , Pickert Geethanjali , Heib Valeska , Fittler Nicola , Steven Sebastian , Luessi Felix , Neerukonda Manjusha , Janoschka Claudia , Tobinski Ann-Marie , Klotz Luisa , Waisman Ari , Schuppan Detlef 
Published: August 2023

ObjectiveWheat has become a main staple globally. We studied the effect of defined pro-inflammatory dietary proteins, wheat amylase trypsin inhibitors (ATI), activating intestinal myeloid cells via toll-like receptor 4, in experimental autoimmune encephalitis (EAE), a model of multiple sclerosis (MS).DesignEAE was induced in C57BL/6J mice on standardised dietary regimes with defined content of gluten/ATI. Mice received a gluten and ATI-free diet with defined carbohydrate and protein (casein/zein) content, supplemented with: (a) 25% of gluten and 0.75% ATI; (b) 25% gluten and 0.19% ATI or (c) 1.5% purified ATI. The effect of dietary ATI on clinical EAE severity, on intestinal, mesenteric lymph node, splenic and central nervous system (CNS) subsets of myeloid cells and lymphocytes was analysed. Activation of peripheral blood mononuclear cells from patients with MS and healthy controls was compared.ResultsDietary ATI dose-dependently caused significantly higher EAE clinical scores compared with mice on other dietary regimes, including on gluten alone. This was mediated by increased numbers and activation of pro-inflammatory intestinal, lymph node, splenic and CNS myeloid cells and of CNS-infiltrating encephalitogenic T-lymphocytes. Expectedly, ATI activated peripheral blood monocytes from both patients with MS and healthy controls.ConclusionsDietary wheat ATI activate murine and human myeloid cells. The amount of ATI present in an average human wheat-based diet caused mild intestinal inflammation, which was propagated to extraintestinal sites, leading to exacerbation of CNS inflammation and worsening of clinical symptoms in EAE. These results support the importance of the gut-brain axis in inflammatory CNS disease.