bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online identity as a collective labeling process
Authors: Barron Alexander T J , ten Thij Marijn , Bollen Johan 
Published: March 2023

Abstract
Expressing identity socially involves a balance between conformity and innovation. One can adopt existing labels to express belonging to a certain community or introduce new labels to express an individual sense of identity. In such a process of co-creation, the existing identity labels of a community shape one’s sense of identity, while individual expression changes that of a community. Social media has introduced new opportunities to study the expression of collective identity. Here we study the group behavior of individuals defining their identities with hashtag self-labels in their Twitter profiles from mid-2017 through 2019. These timelines of personal self-labeling show behavior incorporating innovation, conservation, and social conformity when defining self. We show that the collective co-labeling of popular concepts in the context of identity, such as #resist and #maga, follow the dynamics of a modified Yule–Simon model balancing novelty and conformity. The dynamics of identity expression resemble the collective tagging processes of folksonomies, indicating a similarity between the collective tagging of external objects and the collective labeling of ourselves. Our work underpins a better understanding of how online environments mediate the evolution of collective identity which plays an increasingly important role in the establishment of community values and identity politics.
TCMFP: a novel herbal formula prediction method based on network target’s score integrated with semi-supervised learning genetic algorithms
Authors: Niu Qikai , Li Hongtao , Tong Lin , Liu Sihong , Zong Wenjing , Zhang Siqi , Tian SiWei , Wang Jingai , Liu Jun , Li Bing , Wang Zhong , Zhang Huamin 
Published: March 2023

Abstract
Traditional Chinese medicine (TCM) has accumulated thousands years of knowledge in herbal therapy, but the use of herbal formulas is still characterized by reliance on personal experience. Due to the complex mechanism of herbal actions, it is challenging to discover effective herbal formulas for diseases by integrating the traditional experiences and modern pharmacological mechanisms of multi-target interactions. In this study, we propose a herbal formula prediction approach (TCMFP) combined therapy experience of TCM, artificial intelligence and network science algorithms to screen optimal herbal formula for diseases efficiently, which integrates a herb score (Hscore) based on the importance of network targets, a pair score (Pscore) based on empirical learning and herbal formula predictive score (FmapScore) based on intelligent optimization and genetic algorithm. The validity of Hscore, Pscore and FmapScore was verified by functional similarity and network topological evaluation. Moreover, TCMFP was used successfully to generate herbal formulae for three diseases, i.e. the Alzheimer’s disease, asthma and atherosclerosis. Functional enrichment and network analysis indicates the efficacy of targets for the predicted optimal herbal formula. The proposed TCMFP may provides a new strategy for the optimization of herbal formula, TCM herbs therapy and drug development.
Creating across languages: the poem as process
Authors: Skoulding Zoë 
Published: March 2023

Abstract
This article describes the project Creating Across Languages, a collaboration between GwE, the North Wales regional school improvement service, and commissioned poets working in Welsh, English, and French, in response to the new Curriculum for Wales. A shift away from considering the poem as a challenging object of study, and towards engaging creatively with poetry as a plurilingual process, can provide learners with opportunities to use and experiment with languages at different levels. This is of particular relevance in Wales, where the Curriculum aims to integrate the teaching of Welsh, English, and French, but it also reflects a wider interest in translation in contemporary poetry. The article describes the materials that have been developed so far and reflects on their implementation with a group of Year 9 pupils.
How does the timing of weapon loss influence reproductive traits and trade-offs in the insect Narnia femorata?
Authors: Greenway E V(Ginny) , Angelis Emily , Miller Christine W 
Published: March 2023

Abstract
A longstanding goal of evolutionary biology is to understand among-individual variation in resource allocation decisions and the timing of these decisions. Recent studies have shown that investment in elaborate and costly weapons can result in trade-offs with investment in testes. In this study, we ask the following questions: At what point plasticity in resource allocation to these different structures ceases during development, if at all? Furthermore, can individuals tailor their reproductive behavior to accompany structural changes? We experimentally addressed these questions in the insect Narnia femorata, quantifying resource reallocation across development for the first time, using a phenotypic engineering approach. To investigate whether allocation plasticity diminishes throughout ontogeny, we induced weapon loss at a range of different developmental stages and examined subsequent testes mass and reproductive behavior. We found that relative testes mass increased as weapon investment decreased, implying a direct trade-off between testes and weapon investment. However, autotomy postadulthood ceased to induce larger testes mass. Intriguingly, losing a weapon while young was associated with extended adult mating duration, potentially enabling compensation for reduced fighting ability. Our results highlight the importance of examining the ontogeny of trade-offs between reproductive traits and the flexibility of the relationship between reproductive morphology and behavior.
Integrating behavioural health and primary care: qualitative findings on contextual factors that influence integration
Authors: Jewiss Jennifer , Natkin Lisa W , Clark/Keefe Kelly , Crocker Abigail , Welkowitz Julie A 
Published: March 2023

Abstract

Background
Integrating behavioural health care into primary care practices may increase patients’ access to behavioural health services and improve health outcomes. However, few studies have explored factors that influence integration processes.

Objective
We sought to better understand contextual factors that support or impede behavioural health integration in primary care practices.

Methods
We conducted 71 semi-structured interviews with providers, staff, and leaders from eight primary care practices in the United States with integrated behavioural health services, which were participating in a randomized control, pragmatic trial: Integrating Behavioural Health and Primary Care. Practices were selected for diversity on geographic location, size, ownership, and experience with integration. We conducted a thematic analysis of the qualitative data derived from the interviews.

Results
We identified four categories of contextual factors influencing behavioural health integration: leadership commitment to integration, financial considerations, workflow and communication systems, and providers’ perspectives on integration and team-based healthcare. Supportive factors included leaders’ commitment to integration, adequate staffing, customized communication and workflow systems, collaborative practice culture, and healthy working relationships amongst providers. Impediments included staffing issues and payment models that do not reimburse for activities required to support integrated care.

Conclusion
Interviewees described various benefits of integration, including providers feeling better equipped to address patients’ needs due to collaboration between medical and behavioural providers and resulting interdisciplinary learning. Given concerns about provider burnout, this finding warrants further study.
An update on the management of non-variceal upper gastrointestinal bleeding
Authors: Alali Ali A , Barkun Alan N 
Published: March 2023

AbstractUpper gastrointestinal bleeding (UGIB) continues to be a common gastrointestinal emergency that carries significant morbidity and mortality. The epidemiology of UGIB has been changing over the last few decades with an overall decrease in peptic ulcer disease and increase in the prevalence of other etiologies including vascular lesions and malignancy. Appropriate risk assessment and patient stratification are crucial to ensuring that optimal care is delivered to patients and some risk assessment tools have shown excellent ability to define a low-risk group who can be managed as outpatients safely. Regardless of the etiology of UGIB, resuscitative interventions by primary care providers remain the most important initial measures to improve the outcome for patients including hemodynamic stabilization, an appropriate blood transfusion strategy, with or without acid-lowering agents, while also providing subsequent urgent endoscopic assessment and intervention. In addition, with increasing use of antithrombotic agents in clinical practice and its associated risk of bleeding, the management of such agents in the acute setting has become a real challenge to all physicians. In this article, we provide an up-to-date, evidence-based, practical review of recent changes and advances in UGIB with a focus on non-variceal etiologies.
Impact of a dissemination strategy on family day care educators’ intentions to adopt outdoor free play guidelines introduced in response to COVID-19: a randomized controlled trial
Authors: Lum M , Yoong S L , Wolfenden L , Turon H , Reilly K , Grady A 
Published: March 2023

Abstract
In 2021, guidelines for early childhood education and care were released recommending children are provided access to outdoor areas during all free play sessions to reduce the risk of coronavirus disease of 2019 transmission, aligning with the existing recommendations to increase children’s physical activity. There is a need to understand how to disseminate guidelines in this setting as dissemination is a prerequisite of adoption and implementation. This randomized controlled trial explored the impact of a video-based strategy to disseminate guidelines on family day care educators’ intentions to adopt outdoor free play guidelines. Educators (N = 255) were randomized to receive a video (intervention) or text-based (usual care) resource via email describing recommendations. Educators were invited to participate in a post-intervention survey at 5-week follow-up assessing intentions to adopt guidelines. The secondary outcomes included knowledge, beliefs about capabilities, beliefs about consequences, social/professional role and identity, goals, implementation of guidelines, acceptability of resource and intervention reach. There was no statistically significant difference between groups in intentions to adopt guidelines [ß = 0.01 (95% confidence interval −0.50 to 0.52), P = 0.97], nor for any secondary outcomes. Further investigation is needed to identify effective dissemination strategies in the family day care setting to increase the adoption of public health guidelines.
Network canvas: an open-source tool for capturing social and contact network data
Authors: Janulis Patrick , Phillips Gregory , Melville Joshua , Hogan Bernie , Banner Kate , Mustanski Brian , Oser Carrie B , Tillson Martha , Schneider John , Birkett Michelle 
Published: March 2023

Abstract

Motivation
Social influence and contact networks are extremely important for understanding health behaviour and the spread of disease. Yet, most traditional software tools are not optimized to capture these data, making measurement of personal networks challenging. Our team developed Network Canvas to provide an end-to-end workflow with intuitive interfaces to enable researchers to design and conduct network interviews.

Implementation
Network Canvas consists of three applications (Architect, Interviewer and Server). All applications are written in JavaScript and run on Windows, macOS and Linux; Interviewer also runs on Android and iOS.

General features
Network Canvas substantially reduces the complexity and technical knowledge required to collect network data via three point-and-click applications. The tool has wide applicability for measuring contact and social influence networks in epidemiology.

Availability
Network Canvas is open source and freely available [networkcanvas.com] under the GNU General Public License 3.
From ‘ILCs’ to ‘IPLCs’: A Victory for Indigenous Peoples’ Rights Advocacy Under the Convention on Biological Diversity?
Authors: Zheng Xiaoou 
Published: March 2023

Abstract
Indigenous and local communities (ILCs) are special right-holders under the Convention on Biological Diversity (CBD). Since 2010, the CBD parties have been called upon to adopt the terminology ‘Indigenous Peoples and local communities’ (IPLCs) to better reflect the international human rights development, especially with respect to Indigenous Peoples. The CBD parties agreed to this terminological change in 2014. The very recent CBD decisions and voluntary guidelines have reflected this commitment. This analysis suggests that the inclusion of the term ‘Indigenous Peoples’ in the CBD framework may seem like a victory for Indigenous Peoples’ rights advocacy, but it really is not because important human rights implications have been blocked via complicated restrictions on treaty interpretation. Instead, it indicates a growing divergence in the understanding of the rights of IPLCs in international law.
Modeling Price and Variance Jump Clustering Using the Marked Hawkes Process
Authors: Chen Jian , Clements Michael P , Urquhart Andrew 
Published: March 2023

Abstract
We examine the clustering behavior of price and variance jumps using high-frequency data, modeled as a marked Hawkes process (MHP) embedded in a bivariate jump-diffusion model with intraday periodic effects. We find that the jumps of both individual stocks and a broad index exhibit self-exciting behavior. The three dimensions of the model, namely positive price jumps, negative price jumps, and variance jumps, impact one another in an asymmetric fashion. We estimate model parameters using Bayesian inference by Markov Chain Monte Carlo, and find that the inclusion of the jump parameters improves the fit of the model. When we quantify the jump intensity and study the characteristics of jump clusters, we find that in high-frequency settings, jump clustering can last between 2.5 and 6 hours on average. We also find that the MHP generally outperforms other models in terms of reproducing two cluster-related characteristics found in the actual data.
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
Authors: Imamura Rikiya , Saito Mizuki , Shimada Mikio , Kobayashi Junya , Ishiai Masamichi , Matsumoto Yoshihisa 
Published: March 2023

Abstract
Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA 5′-end, which arises from abortive ligation by DNA ligases. It is also reported that APTX physically binds to XRCC1 and XRCC4, suggesting its involvement in DNA single-strand break repair (SSBR) and DNA double-strand break repair (DSBR) via non-homologous end joining pathway. Although the involvement of APTX in SSBR in association with XRCC1 has been established, the significance of APTX in DSBR and its interaction with XRCC4 have remained unclear. Here, we generated APTX knock-out (APTX−/−) cell from human osteosarcoma U2OS through CRISPR/Cas9-mediated genome editing system. APTX−/− cells exhibited increased sensitivity toward ionizing radiation (IR) and Camptothecin in association with retarded DSBR, as shown by increased number of retained γH2AX foci. However, the number of retained 53BP1 foci in APTX−/− cell was not discernibly different from wild-type cells, in stark contrast to XRCC4-depleted cells. The recruitment of GFP-tagged APTX (GFP-APTX) to the DNA damage sites was examined by laser micro-irradiation and live-cell imaging analysis using confocal microscope. The accumulation of GFP-APTX on the laser track was attenuated by siRNA-mediated depletion of XRCC1, but not XRCC4. Moreover, the deprivation of APTX and XRCC4 displayed additive inhibitory effects on DSBR after IR exposure and end joining of GFP reporter. These findings collectively suggest that APTX acts in DSBR in a manner distinct from XRCC4.
Evaluation of methods to eliminate analytical interference in multiple myeloma patients with spurious hyperphosphatemia
Authors: Tian Xin , Zhao Li , Ma Jin , Lu Jie , Zhu Tian-yi , Liu Yan , Sun Hong-xun 
Published: March 2023

Abstract

Objective
The acid/molybdate assay performed on the Beckman Coulter AU5821 could be subject to paraprotein interference, which potentially results in spurious hyperphosphatemia. We attempted to find a reliable solution to eliminate paraprotein interference in laboratory test results and discuss the causes of paraprotein interference.

Methods
We observed 50 multiple myeloma patients with serum paraproteins. We used the trichloroacetic acid (TCA) deproteinizing method to confirm that paraproteins indeed interfered with phosphate detection in the serum acid/molybdate assay. Furthermore, we used the dry chemical method (Vitros 5.1 FS, Johnson) and deionized water (H2O), normal saline (NS), and healthy human serum as alternative diluents. We assessed the clinical acceptability of the 4 methods by evaluating a bias percentage (bias%) lower than 10% under the premise of TCA treatment as a serum phosphate reference method.

Results
In total, comparing the results of the TCA treatment on the Beckman Coulter AU5821, 3/50 (6%) multiple myeloma patients exhibited phosphate pseudo-elevation (bias% &gt;10%). Additionally, we found pseudo-hypophosphate only in immunoglobulin (Ig)G-kappa paraprotein samples, and all were above 50 g/L. The bias% between TCA and dry chemical method for the 3 patients was below 10%. The maximum acceptable dilutions for patient 22 were 8-fold H2O, 4-fold H2O , and 2-fold serum; those for patient 45 were 16-fold H2O, 16-fold H2O, and 2-fold serum. However, the bias% of patient 40 was beyond the acceptable range in all 3 dilution groups.

Conclusion
High concentrations of IgG kappa–type paraproteins are more likely to interfere with serum phosphorous detection. Both the TCA and dry chemical method can effectively eliminate paraprotein interference.
Antenna source of radio-frequency emission in ion-proton pulsars
Authors: Jones P B 
Published: March 2023

ABSTRACT
The growth of a longitudinal or quasi-longitudinal Langmuir mode in the outward-moving beam of ions and protons that forms the open sector of an ion-proton pulsar magnetosphere radiates as an analogue of an end-fed high-impedance horizontal straight-wire antenna an integral number of half-waves in length. The radiation has, broadly, the energy flux, linear polarization, and spectral index that are widely observed: also, the notch phenomenon seen in some integrated pulse profiles occurs naturally. The new field of pulsar observations below 100 MHz may lead to productive tests of the radio emission mechanism.
Induction of the alternative lengthening of telomeres pathway by trapping of proteins on DNA
Authors: Rose Anna M , Goncalves Tomas , Cunniffe Siobhan , Geiller Helene E B , Kent Thomas , Shepherd Sam , Ratnaweera Malitha , O’Sullivan Roderick J , Gibbons Richard J , Clynes David 
Published: March 2023

Abstract
Telomere maintenance is a hallmark of malignant cells and allows cancers to divide indefinitely. In some cancers, this is achieved through the alternative lengthening of telomeres (ALT) pathway. Whilst loss of ATRX is a near universal feature of ALT-cancers, it is insufficient in isolation. As such, other cellular events must be necessary - but the exact nature of the secondary events has remained elusive. Here, we report that trapping of proteins (such as TOP1, TOP2A and PARP1) on DNA leads to ALT induction in cells lacking ATRX. We demonstrate that protein-trapping chemotherapeutic agents, such as etoposide, camptothecin and talazoparib, induce ALT markers specifically in ATRX-null cells. Further, we show that treatment with G4-stabilising drugs cause an increase in trapped TOP2A levels which leads to ALT induction in ATRX-null cells. This process is MUS81-endonuclease and break-induced replication dependent, suggesting that protein trapping leads to replication fork stalling, with these forks being aberrantly processed in the absence of ATRX. Finally, we show ALT-positive cells harbour a higher load of genome-wide trapped proteins, such as TOP1, and knockdown of TOP1 reduced ALT activity. Taken together, these findings suggest that protein trapping is a fundamental driving force behind ALT-biology in ATRX-deficient malignancies.
CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands
Authors: Rouillon Clément , Eckhardt Bruna V , Kollenstart Leonie , Gruss Fabian , Verkennis Alexander E E , Rondeel Inge , Krijger Peter H L , Ricci Giulia , Biran Alva , van Laar Theo , Delvaux de Fenffe Charlotte M , Luppens Georgiana , Albanese Pascal , Sato Koichi , Scheltema Richard A , de Laat Wouter , Knipscheer Puck , Dekker Nynke H , Groth Anja , Mattiroli Francesca 
Published: March 2023

AbstractDuring every cell cycle, both the genome and the associated chromatin must be accurately replicated. Chromatin Assembly Factor-1 (CAF-1) is a key regulator of chromatin replication, but how CAF-1 functions in relation to the DNA replication machinery is unknown. Here, we reveal that this crosstalk differs between the leading and lagging strand at replication forks. Using biochemical reconstitutions, we show that DNA and histones promote CAF-1 recruitment to its binding partner PCNA and reveal that two CAF-1 complexes are required for efficient nucleosome assembly under these conditions. Remarkably, in the context of the replisome, CAF-1 competes with the leading strand DNA polymerase epsilon (Polϵ) for PCNA binding. However, CAF-1 does not affect the activity of the lagging strand DNA polymerase Delta (Polδ). Yet, in cells, CAF-1 deposits newly synthesized histones equally on both daughter strands. Thus, on the leading strand, chromatin assembly by CAF-1 cannot occur simultaneously to DNA synthesis, while on the lagging strand these processes may be coupled. We propose that these differences may facilitate distinct parental histone recycling mechanisms and accommodate the inherent asymmetry of DNA replication.