bluuebunny/crossref_metadata_2025_split huggingface dataset:
In search of lost fleas: reconsidering Paul-Louis Simond’s contribution to the study of the propagation of plague
Authors: Lynteris Christos 
Published: January 2023

AbstractPaul-Louis Simond’s 1898 experiment demonstrating fleas as the vector of plague is today recognised as one of the breakthrough moments in modern epidemiology, as it established the insect-borne transmission of plague. Providing the first exhaustive examination of primary sources from the Institut Pasteur’s 1897–98 ‘India Mission’, including Simond’s notebooks, experiment carnets and correspondence, and cross-examining this material with colonial medical sources from the first years of the third plague pandemic in British India, the article demonstrates that Simond’s engagement with the question of the propagation of plague was much more complex and ambiguous than the teleological story reproduced in established historical works suggests. On the one hand, the article reveals that the famous 1898 experiment was botched, and that Simond’s misreported its ambiguous findings for the Annales de l’Institut Pasteur. On the other hand, the article shows that, in the course of his ‘India Mission’, Simond framed rats as involved in the propagation of plague irreducibly in their relation to other potential sources of infection and not simply in terms of a parasitological mechanism. The article illuminates Simond’s complex epidemiological reasoning about plague transmission, situating it within its proper colonial and epistemological context, and argues for a new historical gaze on the rat as an ‘epidemiological dividual’, which highlights the relational and contingent nature of epidemiological framings of the animal during the third plague pandemic.
Physicians imprisoned in Franco Spain’s Miranda de Ebro “Campo de Concentración”
Authors: Cuerda-Galindo Esther 
Published: January 2023

AbstractMiranda de Ebro was created in 1937 to imprison Republicans and foreigners who fought with the International Brigades in Spanish Civil War. From 1940, the camp was used only to concentrate detained foreign refugees with no proper documents. More than 15 000 people, most of them from France and Poland, were kept there until the camp was closed in January 1947. Playing both sides of the international divide, fascist Spain at various points in time allowed passage and was a country of refuge both for those escaping Nazism and for Nazis and collaborators who, at the end of World War II (WWII), sought to escape justice. Treatment of each of these groups passing through Miranda was very different: real repression was meted out to the members of the International Brigades (IB), tolerance shown towards those escaping Nazism, and protection and active cooperation given to former Nazis and their collaborators. For the first time, data about foreign physicians imprisoned in Miranda de Ebro were consulted in the Guadalajara Military Archive (Spain). From 1937 to 1947, 151 doctors were imprisoned, most of them in 1942 and 1943, which represents around 1% of the prisoners. Fifty-two of the doctors were released thanks to diplomatic efforts, thirty-two by the Red Cross, and ten were sent to other prisons, directly released or managed to escape. All of them survived. After consulting private and public archives, it was possible to reconstruct some biographies and fill the previous existing gap in the history of migration and exile of doctors during the Second World War.
Transfer learning as a method to reproduce high-fidelity non-local thermodynamic equilibrium opacities in simulations
Authors: Vander Wal Michael D. , McClarren Ryan G. , Humbird Kelli D. 
Published: January 2023

Simulations of high-energy density physics often need non-local thermodynamic equilibrium opacity data. These data, however, are expensive to produce at relatively low fidelity. It is even more so at high fidelity such that the opacity calculations can contribute 95 % of the total computation time. This proportion can even reach large proportions. Neural networks can be used to replace the standard calculations of low-fidelity data, and the neural networks can be trained to reproduce artificial, high-fidelity opacity spectra. In this work, it is demonstrated that a novel neural network architecture trained to reproduce high-fidelity krypton spectra through transfer learning can be used in simulations. Further, it is demonstrated that this can be done while achieving a relative per cent error of the peak radiative temperature of the hohlraum of approximately 1 % to 4 % while achieving a 19.4

$\times$

speed up.
Scale quality in second-language anxiety and WTC: A methodological synthesis
Authors: Sudina Ekaterina 
Published: January 2023

AbstractAs survey research in second language acquisition grows in popularity, the adherence to best practices associated with questionnaire quality is critical for a better understanding of factors that influence second language (L2) development. To ensure that a self-report scale targets the construct of interest and does it consistently and accurately, authors of primary research should demonstrate that their instrument possesses acceptable evidence of validity and reliability. To this end, this methodological synthesis focused on the state of scale quality in L2 anxiety and willingness to communicate (WTC) research by examining key methodological issues of quantitative survey research and offering empirically grounded suggestions for future studies. A close examination of 232 peer-reviewed articles that used 385 L2 anxiety and WTC scales demonstrated, among other findings, the lack of evidence for scale content and construct validity. The implications of this study contribute to concurrent attempts at methodological reform in applied linguistics.
Intra-abdominal haemorrhaging after cardiac catheterisation: the importance of recognising vascular anomalies in heterotaxy syndrome
Authors: Yamada Yuya , Ishikawa Yuichi , Sagawa Koichi 
Published: January 2023

AbstractA 2-month-old boy with a single ventricle underwent cardiac catheterisation. Inferior vena cava angiography at the end of the examination revealed local stenosis, flexion, and connection to the right hepatic vein. Six hours after catheterisation, he went into haemorrhagic shock. CT revealed contrast extravasation into the liver with ascites. A precise diagnosis of vascular anomalies is mandatory, especially in patients with heterotaxy syndrome.
50 Years of Terrorism against the Nuclear Industry: A Review of 91 Incidents in the Global Terrorism Database
Authors: De Cauwer Harald , Barten Dennis G. , Tin Derrick , Mortelmans Luc J. , Ciottone Gregory R. , Somville Francis 
Published: January 2023

AbstractBackground:The on-going Russo-Ukrainian war has resulted in a renewed global interest in the safety and security of nuclear installations and the possibility of nuclear disasters caused by warfare and terrorism.The objective of this study was to identify and characterize all documented terrorist attacks against nuclear transport, nuclear facilities, and nuclear scientists as reported to the Global Terrorism Database (GTD) over a 50-year period.Methods:The GTD was searched for all terrorist attacks against nuclear facilities, nuclear scientists, nuclear transport, and other nuclear industry-related targets in the period from 1970-2020. Analyses were performed on temporal factors, location, target type, attack and weapon type, perpetrator type, number of casualties, and property value loss.Results:Ninety-one incidents that occurred from 1970 through 2020 were included. Incidents took place in 25 countries and nine world regions, with most (42; 46.1%) occurring in Western Europe.During these 50 years, 91 incidents resulted in 19 fatalities and 117 injuries. One perpetrator was killed during an incident and one other assailant was injured.Bombings and explosions were the most frequently identified attack type (n = 40; 44.0%), followed by facility/infrastructure damage (n = 24; 26.4%) and armed assaults and assassinations (both n = 7; 7.7%).Nuclear power plants and reactors under construction were targeted in 13 (14.3%) and eight (8.8%) incidents, respectively. Most of the attacks took place on other nuclear industry-related sites.Conclusion:Terrorist attacks carried out by non-state perpetrators against nuclear facilities, nuclear scientists, nuclear transport, and other nuclear industry-related targets are rare, with only 91 incidents in a 50-year period. None of the attacks resulted in radioactive fallout or environmental contamination. Most of the attacks took place outside a nuclear power plant.
Strong Nonlinearity of Land Climate‐Carbon Cycle Feedback Under a High CO2 Growth Scenario
Authors: Zhang Xuanze , Wang Ying‐Ping , Zhang Yongqiang 
Published: January 2023

AbstractProjections of future climate change for given CO2 and other greenhouse gas emission scenarios depend on the response of global climate‐carbon cycle feedback, which consists of carbon‐concentration feedback (e.g., CO2 physiology effect on land carbon sink) and carbon‐climate feedback (e.g., CO2 radiative effect on land carbon sink). Previous studies have assumed no significant interaction between these two feedbacks within the Earth system. This study quantifies the interaction of these two feedbacks, or the nonlinear feedback on land using the fully, biogeochemically, and radiatively coupled simulations under a 1% yr−1 CO2 increase path from nine Earth system models of the Coupled Model Intercomparison Project Phase 6 (CMIP6). The results show that the nonlinear feedback is 1.64 ± 2.92 × 10−2 GtC ppm−1 K−1 at the end of 140‐year simulation with a quadrupling CO2 (4 × CO2), where its strength is 11% ± 18% of the carbon‐concentration feedback or −27% ± 49% of the carbon‐climate feedback on land. Compared to previous assumptions that did not consider this interaction, the nonlinear feedback contributes about 8% ± 12% of the land carbon increase accumulated at the 4 × CO2. The nonlinear feedback largely results from the combined effect of increased CO2‐induced additional fertilization effect on warming‐induced additional leaf area index and vegetation productivity over the Northern Hemisphere. The magnitude of the nonlinear feedback on land decreases with an increase in atmospheric CO2 or warming under the high emission scenario. This study highlights the significance of land nonlinear climate‐carbon cycle feedback in increasing land carbon sink and slowing down future climate change.
Fine‐Scale Electric Fields and Joule Heating From Observations of the Aurora
Authors: Krcelic P. , Fear R. C. , Whiter D. , Lanchester B. , Aruliah A. L. , Lester M. , Paxton L. 
Published: January 2023

AbstractOptical measurements from three selected wavelengths have been combined with modeling of emissions from an auroral event to estimate the magnitude and direction of small‐scale electric fields on either side of an auroral arc. The temporal resolution of the estimates is 0.1 s, which is much higher resolution than measurements from Super Dual Auroral Radar Network (SuperDARN) in the same region, with which we compare our estimates. Additionally, we have used the Scanning Doppler Imager instrument to measure the neutral wind during the event in order to calculate the height integrated Joule heating. Joule heating obtained from the small scale electric fields gives larger values (17 ± 11 and 6 ± 9 mWm−2 on average on each side of the arc) than the Joule heating obtained from more conventionally used SuperDARN data (5 mWm−2). This result is significant, because Joule heating will cause changes in the thermosphere from thermal expansion and thermal conductivity, and may also affect the acceleration of the neutral wind. Our result indicates that high spatial and temporal resolution electric fields may play an important role in the dynamics of the magnetosphere‐ionosphere‐thermosphere system.
Spatiotemporal Variations of Surface Deformation, Shallow Creep Rate, and Slip Partitioning Between the San Andreas and Southern Calaveras Fault
Authors: Li Yuexin , Bürgmann Roland , Taira Taka'aki 
Published: January 2023

AbstractThe Calaveras Fault (CF) branches from the San Andreas Fault (SAF) near San Benito, extending sub‐parallel to the SAF for about 50 km with only 2–6 km separation and diverging northeastward. Both the SAF and CF are partially coupled, exhibit spatially variable aseismic creep and have hosted moderate to large earthquakes in recent decades. Understanding how slip partitions among the main fault strands of the SAF system and establishing their degree of coupling is crucial for seismic hazard evaluation. We perform a timeseries analysis using more than 5 years of Sentinel‐1 data covering the Bay Area (May 2015–October 2020), specifically targeting the spatiotemporal variations of creep rates around the SAF‐CF junction. We derive the surface creep rates from cross‐fault InSAR timeseries differences along the SAF and CF including adjacent Sargent and Quien Sabe Faults. We show that the variable creep rates (0–20 mm/yr) at the SAF‐CF junction are to first order controlled by the angle between the fault strike and the background stress orientation. We further examine the spatiotemporal variation of creep rates along the SAF and CF and find a multi‐annual coupling increase during 2016–2018 the subparallel sections of both faults, with the CF coupling change lagging behind the SAF by 3–6 months. Similar temporal variations are also observed in both b‐values inferred from declustered seismicity and aseismic slip rates inferred from characteristic repeating earthquakes.
Bark Beetle Effects on Fire Regimes Depend on Underlying Fuel Modifications in Semiarid Systems
Authors: Ren Jianning , Hanan Erin J. , Hicke Jeffrey A. , Kolden Crystal A. , Abatzoglou John T. , Tague Christina (Naomi) L. , Bart Ryan R. , Kennedy Maureen C. , Liu Mingliang , Adam Jennifer C. 
Published: January 2023

AbstractAlthough natural disturbances such as wildfire, extreme weather events, and insect outbreaks play a key role in structuring ecosystems and watersheds worldwide, climate change has intensified many disturbance regimes, which can have compounding negative effects on ecosystem processes and services. Recent studies have highlighted the need to understand whether wildfire increases or decreases after large‐scale beetle outbreaks. However, observational studies have produced mixed results. To address this, we applied a coupled ecohydrologic‐fire regime‐beetle effects model (RHESSys‐WMFire‐Beetle) in a semiarid watershed in the western US. We found that in the red phase (0–5 years post‐outbreak), surface fire extent, burn probability, and surface and crown fire severity all decreased. In the gray phase (6–15 years post‐outbreak), both surface fire extent and surface and crown fire severity increased with increasing mortality. However, fire probability reached a plateau during high mortality levels (>50% in terms of carbon removed). In the old phase (one to several decades post‐outbreak), fire extent and severity still increased in all mortality levels. However, fire probability increased during low to medium mortality (≤50%) but decreased during high mortality levels (>50%). Wildfire responses also depended on the fire regime. In fuel‐limited locations, fire probability increased with increasing fuel loads, whereas in fuel‐abundant (flammability‐limited) systems, fire probability decreased due to decreases in fuel aridity from reduced plant water demand. This modeling framework can improve our understanding of the mechanisms driving wildfire responses and aid managers in predicting when and where fire hazards will increase.
Glycemic control in gestational diabetes and impact on biomarkers in women and infants
Authors: Hofer Olivia J. , Alsweiler Jane , Tran Thach , Crowther Caroline A. 
Published: January 2023

Abstract
Background
Gestational diabetes mellitus (GDM) is linked to the dysregulation of inflammatory markers in women with GDM compared to women without. It is unclear whether the intensity of glycemic control influences these biomarkers. We aimed to assess whether different glycemic targets for women with GDM and compliance influence maternal and infant biomarkers.

Methods
Maternity hospitals caring for women with GDM were randomized in the TARGET Trial to tight or less tight glycemic targets. Maternal blood was collected at study entry, 36 weeks’ gestation, and 6 months postpartum, and cord plasma after birth. We assessed compliance to targets and concentrations of maternal serum and infant biomarkers.

Results
Eighty-two women and infants were included in the study. Concentrations of maternal and infant biomarkers did not differ between women assigned to tighter and less tight glycemic targets; however, concentrations were altered in maternal serum leptin and CRP and infant cord C-peptide, leptin, and IGF in women who complied with tighter targets.

Conclusions
Use of tighter glycemic targets in women with GDM does not change the concentrations of maternal and infant biomarkers compared to less tight targets. However, when compliance is achieved to tighter targets, maternal and infant biomarkers are altered.

Impact

The use of tighter glycemic targets in gestational diabetes does not result in changes to maternal or cord plasma biomarkers. However, for women who complied with tighter targets, maternal serum leptin and CRP and infant cord C-peptide, leptin and IGF were altered compared with women who complied with the use of the less tight targets.

This article adds to the current evidence base regarding the impact of gestational diabetes on maternal and infant biomarkers.

This article highlights the need for further research to assess enablers to meet the tighter target recommendations and to assess the impact on relevant biomarkers.
WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis
Authors: You Yunhao , Liu Jincheng , Zhang Lu , Li Xiang , Sun Zhenqian , Dai Zihan , Ma Jinlong , Jiao Guangjun , Chen Yunzhen 
Published: January 2023

AbstractAn imbalance in the differentiation potential of bone marrow mesenchymal stem cells (BMSCs) is an important pathogenic mechanism underlying osteoporosis (OP). N6-methyladenosine (m6A) is the most common post-transcriptional modification in eukaryotic cells. The role of the Wilms’ tumor 1-associated protein (WTAP), a member of the m6A functional protein family, in regulating BMSCs differentiation remains unknown. We used patient-derived and mouse model-derived samples, qRT-PCR, western blot assays, ALP activity assay, ALP, and Alizarin Red staining to determine the changes in mRNA and protein levels of genes and proteins associated with BMSCs differentiation. Histological analysis and micro-CT were used to evaluate developmental changes in the bone. The results determined that WTAP promoted osteogenic differentiation and inhibited adipogenic differentiation of BMSCs. We used co-immunoprecipitation (co-IP), RNA immunoprecipitation (RIP), methylated RNA immunoprecipitation (MeRIP), RNA pulldown, and dual-luciferase assay to explore the direct mechanism. Mechanistically, the expression of WTAP increased during osteogenic differentiation and significantly promoted pri-miR-181a and pri-miR-181c methylation, which was recognized by YTHDC1, and increased the maturation to miR-181a and miR-181c. MiR-181a and miR-181c inhibited the mRNA expression of SFRP1, promoting the osteogenic differentiation of BMSCs. Our results demonstrated that the WTAP/YTHDC1/miR-181a and miR-181c/SFRP1 axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis.
Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics
Authors: Liu Xuanyu , Yin Kunlun , Chen Liang , Chen Wen , Li Wenke , Zhang Taojun , Sun Yang , Yuan Meng , Wang Hongyue , Song Yunhu , Wang Shuiyun , Hu Shengshou , Zhou Zhou 
Published: January 2023

AbstractHypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder characterized by cardiomyocyte hypertrophy and cardiac fibrosis. Pathological cardiac remodeling in the myocardium of HCM patients may progress to heart failure. An in-depth elucidation of the lineage-specific changes in pathological cardiac remodeling of HCM is pivotal for the development of therapies to mitigate the progression. Here, we performed single-nucleus RNA-seq of the cardiac tissues from HCM patients or healthy donors and conducted spatial transcriptomic assays on tissue sections from patients. Unbiased clustering of 55,122 nuclei from HCM and healthy conditions revealed 9 cell lineages and 28 clusters. Lineage-specific changes in gene expression, subpopulation composition, and intercellular communication in HCM were discovered through comparative analyses. According to the results of pseudotime ordering, differential expression analysis, and differential regulatory network analysis, potential key genes during the transition towards a failing state of cardiomyocytes such as FGF12, IL31RA, and CREB5 were identified. Transcriptomic dynamics underlying cardiac fibroblast activation were also uncovered, and potential key genes involved in cardiac fibrosis were obtained such as AEBP1, RUNX1, MEOX1, LEF1, and NRXN3. Using the spatial transcriptomic data, spatial activity patterns of the candidate genes, pathways, and subpopulations were confirmed on patient tissue sections. Moreover, we showed experimental evidence that in vitro knockdown of AEBP1 could promote the activation of human cardiac fibroblasts, and overexpression of AEBP1 could attenuate the TGFβ-induced activation. Our study provided a comprehensive analysis of the lineage-specific regulatory changes in HCM, which laid the foundation for targeted drug development in HCM.
Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a randomised, placebo-controlled, double-blind study
Authors: Takahashi Masaki , Mineshita Yui , Yamagami Jumpei , Wang Chunyi , Fujihira Kyoko , Tahara Yu , Kim Hyeon-Ki , Nakaoka Takashi , Shibata Shigenobu 
Published: January 2023

Abstract
Background/Objectives
Glucose tolerance is controlled by the internal clock and is worse in the evening. From a chrononutrition perspective, diabetes prevention requires evaluating the antidiabetic effects of the timing of functional ingredients and nutrient intake. The purpose of this study was to investigate the timing effects of acute mulberry leaf extract (MLE) intake on postprandial glucose levels in young adults.

Subjects/Methods
Twelve young adults underwent four trials. Blood samples were collected in a fasting state and at 30, 60, 120, and 180 min after eating a mixed meal. The study had a randomised, placebo-controlled, double-blind trial design involving: (1) morning placebo trial (08:00 h; MP trial), (2) evening placebo trial (18:00 h; EP trial), (3) morning MLE trial (08:00 h; MM trial), and (4) evening MLE trial (18:00 h; EM trial).

Results
The incremental area under the blood glucose curve (iAUC) in the EM trials was significantly lower than that in the EP trials (P = 0.010). The postprandial glucose concentrations 120 min after the meal were significantly lower in the EM trials than those in the EP trials (P = 0.006). The postprandial insulin concentrations at 120 min were significantly lower in the MM trials than those in the MP trials (P = 0.034). Moreover, the postprandial insulin concentrations 180 min after the meal were significantly lower in the EM trials than those in the EP trials (P = 0.034).

Conclusions
MLE intake in the evening, but not in the morning, was effective in improving glucose tolerance.

Trial registration
Clinical trial reference: UMIN 000045301; website of trial registry: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051340.