bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of thyroid hormone treatment on maternal pregnancy outcomes in women with subclinical hypothyroidism without TPOAb
Authors: Sitoris Georgiana , Veltri Flora , Jelloul Emna , Kleynen Pierre , Rozenberg Serge , Poppe Kris G 
Published: December 2022

Abstract
Purpose: To investigate the impact of thyroid hormone treatment (LT4) on maternal pregnancy outcomes in women with subclinical hypothyroidism (SCH) without thyroid peroxidase antibodies (TPOAb) positivity.
Design/Methods: Single centre, cross-sectional study in 1460 women screened for TSH, free T4 and TPOAb at median 13 (11-17) weeks of gestation during the period 2013-2014. Exclusion criteria were twin- and assisted reproduction pregnancies, TPO positivity, overt hyperthyroidism, and treatment with LT4 before screening. The impact of LT4 on maternal pregnancy outcomes was investigated in a group of 53 women with SCH (TSH >3.74 mIU/L) in which LT4 was initiated at median 13 (10-22) weeks (treated group). The control group included 18 women with SCH (TSH >3.74 mIU/L; untreated group). The prevalence of pregnancy complications in these two groups was compared with that in a reference group of 1389 women (TSH £3.74 mIU/L and no TPOAb; REF group).
Results: The prevalence of pre-eclampsia and gestational diabetes (GDM) was higher in the control group vs that in the REF group (16.7% vs 5.0% and 27.8% vs 18.9%; p=0.017 and p=0.016, respectively), but comparable in the LT4 treated SCH group vs the REF group (7.6% vs 5.0% and 22.6% vs 18.9%; p=0.918 and 0.676, respectively). The prevalence of iron-deficiency anaemia was lower in the LT4 treated vs the REF group (17.0% vs 32.5%; p=0.017).
Conclusions: Pregnant women with SCH and without TPOAb positivity who were LT4 untreated had a higher prevalence of pre-eclampsia and GDM compared with euthyroid women, while this was not the case when SCH women were treated with LT4, even when it was initiated after the first trimester.
Simulation of a plausible great earthquake (Mw 8.0) sourced on down-going Indian slab beneath Indo-Burmese wedge and its implications for North East (NE) Indian region
Authors: Chingtham Prasanta , Sharma Babita , Mohan Kapil , Mittal Himanshu 
Published: December 2022

Abstract
The 4th January 2016 Manipur earthquake (Mw 6.7) occurred along the Indo-Burmese wedge and ruptured towards NW direction causing severe damage to buildings/structures in North-East (NE) Indian region. A plausible earthquake (Mw 8.0) is simulated to estimate the ground motions and associated seismic hazard by means of the waveforms of 2016 Manipur earthquake (Mw 6.7) as an element earthquake considering the source in the subduction boundary of the Indo-Burmese wedge at an intermediate depth. The empirical greens function mechanism (EGFM) is adopted to accomplish the better utilization of the observed ground motions of the recorded earthquake as an element earthquake and to achieve the probable ground motions in order to acquire the appropriate path/site effects in the simulated ground motions. The obtained results demonstrate the impact of the comparable rupture directivity pattern in both element as well as the simulated earthquakes. The Peak Ground Acceleration (PGA) in NE India from element and simulated earthquakes vary from 3 cm/sec2 and 11 cm/sec2 to 103 cm/sec2 and 342 cm/sec2 at epicentral distances of 624 km and 53 km respectively. The high amplitude surface waves due to the interference of seismic waves along with the combined effects of rupture directivity and site amplification showcased the highest PGA value at Shillong (SHL). This site is located on Pre-Cambrian rock and situated at an epicentral distance of 214 km from the source zone, which is lying at an intermediate depth that might have propelled the direct seismic waves of higher intensity at a longer distance compared to other sites. The outcome of the present study highlights the significance of varied ground motion parameters among the observed sites to the extent of bearing the damage potential of strong ground motions. The related analysis also advocates for the simulated PGA variations and associated duration of the earthquake waveforms exposed on different geological formations that have strong bearings on the seismic risk involved with future probable great earthquake in the study region. Moreover, simulated ground motions of expected plausible disastrous earthquakes on numerous geological formations beneath the various sites have significant impacts on designing critical structures/buildings such as schools, hospitals, bridges, dams and nuclear power plants for NE India. Thus, the detailed investigations on ground motion parameters, simulation of ground motion and the influence of different geological/geomorphological conditions on duration, shape and maximum amplitude of ground motion may be supportive for implementing earthquake risk and mitigation plans in order to assess the seismic hazard of the study region.
Clinical Prediction Model for Severe Pain After Percutaneous Nephrolithotomy and Analysis of Associated Factors ：A Retrospective Study
Authors: Wei Yuzhi , Wu Haotian , Qi Ziheng , Feng Chunyu , Yang Bo , Yin Haolin , Wang Lu , Zhang Huan 
Published: December 2022

AbstractObjectives:This study aimed to develop severe pain prediction models for patients after percutaneous nephrolithotomy (PCNL), to identify and intervene the risk factors causing pain in a timely manner so as to improve patient satisfaction after surgery.Methods:The clinical data of 331 PCNL patients were retrospectively analyzed. Data of 265 patients (80%) were randomly selected as the training cohort and those of 66 (20%) patients were selected as the validation cohort. We choosed clinical data through the stepwise Akaike information criterion and best subset selection to build severe pain prediction models by the training data set. The validity of the model was verified and analyzed using the test data set.Results:The first clinical model was developed using the American Society of Anesthesiologists (ASA) classification, number of kidney stones, history of hydronephrosis, duration of surgery, and presence of stone remnants after surgery. This model had an area under the curve (AUC) of 0.8682 (95% confidence interval [CI], 0.8205–0.9160), threshold of 0.4771, sensitivity of 97.25%, specificity of 63.86%, and negative predictive value (NPV) of 91.38%. The second model was developed using the mentioned above six clinical features and size of kidney stones. This model showed a stronger discriminatory power (P=0.208), with an AUC of 0.8710 (95% CI, 0.8242–0.9187), threshold of 0.4813, sensitivity of 97.25%, specificity of 83.86%, and NPV of 91.38%. In the subsequent validation cohort (N = 66), the AUC (95% CI) was 0.9093 (0.8378–0.9808) for the first clinical model and 0.9098 (0.8373–0.9823) for the second clinical models.Conclusion:We developed two prediction models for postoperative pain severity in PCNL patients, which were validated internally.Trial registration:This is a retrospective study that does not include sensitive patient data, but only data provided by professionals from selected centres about their daily clinical practice. Therefore, our ethics Committee did not consider it necessary to register the study.
Hierarchical V4C3TX@NiO-reduced graphene oxide heterostructure hydrogel and defective reduced graphene oxide hydrogel as free-standing anode and cathode for high-performance asymmetric supercapacitor
Authors: Tian Yuqin , Chen Weiwen , Qiu Zenghui , Jing Jian , Xu Haijun , Pan Dingjie , Chen Shaowei 
Published: December 2022

AbstractAsymmetric supercapacitors (ASCs) based on a battery-type anode and a capacitive-type cathode have been attracting extensive interest because of their high energy density. Herein, NiO nanosheets are hydrothermally deposited onto a V4C3TXsubstrate, which are then assembled into a 3D porous heterostructure hydrogel through a graphene oxide-assisted self-convergence hydrothermal process at low temperatures. The resultant hierarchical V4C3TX@NiO-reduced graphene oxide (RGO) hydrogel exhibits an ultrahigh specific capacitance up to 1014.5 F g− 1at 1 A g− 1. Separately, a defective reduced graphene oxide (DRGO) hydrogel is prepared by a cost-effective hydrothermal procedure followed by cobalt-catalyzed gasification, which shows a higher specific capacitance (258 F g− 1at 1 A g− 1) than untreated RGO hydrogel (176 F g− 1). These two electrodes are then assembled into an ASC, the device features a stable operating voltage of 1.8 V, a maximum energy density of 86.22 Wh kg− 1at 900 W kg− 1, along with good cycling stability at 96.4% capacitance retention after 10,000 cycles at 10 A g− 1. This work highlights the unique potential of MXenes-based materials for the construction of high-performance ASCs.
A Computed tomography (CT) based morphometric study of superior pubic ramus anatomy among Arabs to determine safe intramedullary pubic rami screw insertion
Authors: Jarragh Ali , Lari Ali , Sheikh Mehraj 
Published: December 2022

Abstract
Purpose
To measure the morphometric variables of the superior pubic ramus in a sub-set of an Arab population to establish a safe pubic screw fixation technique.
Methods
Cross sectional retrospective analysis of computed tomography (CT) pelvis images for 231 participants. The morphometric analysis included; pubic ramus axis length, insertion angles orientation, distance from the exit point to the pubic symphysis, distance from the entry point to acetabular joint surface and assessment of the narrowest pubic ramus diameter at three anatomical zones: para-symphyseal, mid-pubic and supra-acetabular areas. Pubic rami diameter correlation with age and sex was also analyzed.
Results
A total of 231 participants were included (55% male, 45% female). The mean screw length was between (104–127 mm) and it is significantly higher in males than females. The narrowest canal diameter was found at the para symphyseal area in both sexes were; 7.35mm in males and 4.75 mm in females. In females, all canal diameters at the three measured regions were significantly smaller than male’s diameters. The mediolateral insertion angle was significantly higher in females than males (49.4° vs. 41.8°, respectively), whereas the cephalic-caudal angle was significantly higher in males than females (49.9° vs. 42.1° respectively). The mean distance from the lateral ilium entry point to joint articular surface was higher in males (23.5 mm) than females (19.9 mm).The symphysis pubis to tubercle exit point was significantly higher in females than males (24.2 mm vs 16.6 mm respectively). Pearson’s correlation analysis revealed a statistically significant positive correlation between age and the pubic ramus diameter at the three measured regions in all age groups.
Conclusion
The results from this study suggest that percutaneous pubic rami screw fixation using the standard 6.5 or 7.3mm cannulated screw system may potentially be unsafe in female Arab patients. Thus, a closer evaluation in this subset of patients may require the alternative solid non-cannulated screws (3.5- 4.5mm) or plate fixation options. Further, female patients may have a higher risk of acetabular joint penetration, while males have a potentially higher risk of pudendal nerve injury
Metagenomic and culture-dependent approaches unveil active microbial community and novel functional genes involved in arsenic mobilization and detoxification in groundwater
Authors: Diba Farzana , Hoque M. Nazmul , Rahman M. Shaminur , Rahman Md. Khandakar Jaminur , Moniruzzaman Md. , Khan Mala , Hossain M. Anwar , Sultana Munawa 
Published: December 2022

Abstract
Background: Arsenic (As) and its species are major pollutants in ecological bodied including groundwater in Bangladesh rendering serious public health concern. Bacteria with arsenotrophic genes have been found in the aquifer, converting toxic arsenite [As (III)] to less toxic arsenate [As (V)] that is easily removed using chemical and biological trappers. In this study, genomic and metagenomic approaches parallel to culture-based assay (Graphical abstract) have made it possible to decipher phylogenetic diversity of groundwater arsenotrophic microbiomes along with elucidation of their genetic determinants.
Results: Seventy-two isolates were retrieved from six As-contaminated (average As concentration of 0.23 mg/L) groundwater samples from Munshiganj and Chandpur districts of Bangladesh. Twenty-three isolates harbored arsenite efflux pump (arsB) gene with high abundance, and ten isolates possessing arsenite oxidase (aioA) gene, with a wide range of minimum inhibitory concentration, MICAs (2 to 32 mM), confirming their role in arsenite metabolism. Shotgun metagenomic analysis revealed considerable parallels with the culture-dependent method proving their complementarity in detecting native population bacteria in As containing aquifers. There was considerable heterogeneity in species richness and microbial community structure. Microbial taxa from Proteobacteria, Firmicutes and Acidobacteria dominated these diversities. Through these combinatorial approaches, we have identified potential candidates such as, Pseudomonas, Acinetobacter, Stenotrophomonas, Achromobacter, Paraburkholderia, Comamonas and Klebsiella and associated functional genes (arsB, acr3, arsD, arsH, arsR) that could significantly contribute to arsenite detoxification, accumulation, and immobilization.
Conclusions: Culture-dependent and -independent shotgun metagenomic investigation elucidated arsenotrophic microbiomes and their functions in As biogeochemical transformation. These findings provide scientific basis for mitigating arsenic pollution in the groundwater of Bangladesh and beyond.
Correlation between Serum Heat Shock Protein 27 and Interleukin- 17 Levels and Prognosis in Patients with Acute Myocardial Infarction
Authors: Hu Ende , Ke Jiaxing , Lu Nan , Lin Xinmiao , Chen Sen , Chen Haifeng 
Published: December 2022

Abstract
Background
Heat shock protein 27 (HSP27) and interleukin-17 (IL-17) are important indicators of inflammation. Whether serum HSP27 and IL-17 levels hold predictive value on the prognosis of patients with acute myocardial infarction (AMI) remains unclear.
Methods
This was a prospective cohort study enrolled 140 patients in the Department of Cardiology of Fujian Provincial Hospital from December 2020 to June 2021, including 40 patients of non-AMI and 100 patients of AMI. The levels of serum HSP27, Phosphorylated HPS27 (pHSP27) and IL-17 were measured by enzyme linked immunosorbent assay. Patients with AMI were followed up. The follow-up endpoint was major adverse cardiovascular events (MACEs), including recurrent angina pectoris, re-admission heart failure, re-admission myocardial infarction, stroke, and death. And follow-up ended on December 31, 2021.
Results
HSP27, pHSP27 and IL-17 were higher in AMI patients than in non-AMI patients (All P < 0.05). HSP27 level was negatively correlated with troponin I level (r = -0.243, P < 0.05). And there were negative correlations between HSP27, IL-17 and Gensini scores, respectively (r(HSP27)=-0.374, P = 0.002;r(IL−17) = -0.289, P = 0.016). All 100 patients with AMI were followed up. The median follow-up was 8 months. There were 30 cases of MACEs. The area under the receiver operating characteristic curve for the predict of MACEs was higher for joint model (combining HSP27, pHSP27 and IL-17) than for HSP27, pHSP27 and IL-17 alone. Univariate COX regression analysis showed that HSP27 (HR = 0.968, P = 0.01), pHSP27 (HR = 0.972, P = 0.039) and IL-17 (HR = 0.979, P = 0.004) were protective factors for endpoint free survival. HSP27 and IL-17 were associated with MACEs after correction for confounding factors (HR(HSP27) = 0.972, P = 0.39; HR(IL−17) = 0.979, P = 0.004).
Conclusion
HSP27, pHSP27 and IL-17 were higher in AMI patients than in non-AMI patients. But HSP27, pHSP27 and IL-17 could reduce the occurrence of MACEs in AMI patients.
Increased expression of inactive rhomboid protein 2 in circulating monocytes after acute myocardial infarction
Authors: Dijck Phillip , Hannemann Carmen , Dreger Henryk , Stangl Verena , Stangl Karl , Ludwig Antje , Hewing Bernd 
Published: December 2022

Abstract
Purpose
Tumor necrosis factor-alpha (TNF-α) blood levels increase following acute myocardial infarction (AMI); TNF-α is involved in impaired recovery of myocardial function following AMI. The interaction of inactive rhomboid protein 2 (iRhom2) with TNF-α converting enzyme (TACE) is required for shedding of TNF-α from the cell surface of immune cells. In this pilot study, we hypothesized that iRhom2 expression increases in circulating monocytes following AMI.
Methods
Circulating monocytes were MACS-sorted from peripheral blood of 50 AMI patients at admission (day 1) and 3 days after admission. mRNA was isolated from sorted monocytes and expression levels of iRhom2, TACE and TNF-α were evaluated by real-time RT-PCR. Serum TNF-α levels were determined. Circulating monocyte subsets were quantified by flow cytometry. Left ventricular (LV) function was measured by echocardiography.
Results
We observed a significant increase of iRhom2 mRNA expression in monocytes (p = 0.012), of intermediate monocytes levels (p < 0.001), and of serum TNF-α levels (p < 0.001) at day 3 following AMI compared to day 1. In contrast, TNF-α and TACE mRNA expression in monocytes remained unchanged. At day 3, iRhom2 mRNA expression in monocytes positively correlated with levels of intermediate monocytes (r = 0.37, p = 0.009) and serum TNF-α levels (r = 0.33, p = 0.019). iRhom2 mRNA expression in monocytes at day 3 negatively correlated with LV systolic function (r=-0.34, p = 0.025).
Conclusions
This study suggests that iRhom2 contributes to the regulation of inflammation and is thereby associated with LV dysfunction following AMI. Thus, iRhom2 modulation should be further evaluated as a potential therapeutic strategy to attenuate adverse cardiac remodeling in AMI patients.
Faecalibacterium prausnitzii Reduces Plasma Lipopolysaccharide and Inhibits Atherosclerosis
Authors: Yang Hai-Tao , Liu Jing-Kun , Wu Ting-Ting , Yang Yi , Wu Cheng-Xin , Hou Xian-Geng , Zheng Ying-Ying , Ma Yi-Tong , Xie Xiang 
Published: December 2022

Abstract
Background
The gut microbiota is related to the occurrence and development of coronary artery disease (CAD). However, the specific target of gut microbiota in preventing CAD is rarely reported. The aim of this study was to identify important specific targets through metagenomics and untargeted metabolomics and to verify their relationships with atherosclerosis.
Methods
A total of 371 participants with CAD of varying severity and controls without CAD were recruited. Then, metagenomic sequencing and untargeted metabolite sequencing were used to search for important markers in faecal samples. Mice predisposed to atherosclerosis were then used to investigate the underlying mechanisms of the relationship between these species and atherosclerosis.
Results
The results of faecal metagenomics sequencing and untargeted metabolite sequencing in the CAD group and control group showed that the population with a high abundance of Faecalibacterium prausnitzii(F. prausnitzii) had the lowest incidence of CAD, and random forest importance analysis also revealed the relationship between F. prausnitzii and CAD. Moreover, we also found that F. prausnitzii was equally effective in predicting CAD alone. F. prausnitzii reduced the formation of atherosclerotic lesions in ApoE−/− mice by gavage. The mechanism involves reduction of the synthesis level of intestinal LPS and improvement of intestinal permeability by strengthening the mechanical barrier and mucosal barrier to reduce the level of plasma LPS, leading to systemic inflammation and local inflammatory reactions in the aorta, thus achieving an anti-atherosclerotic effect.
Conclusions
Sequencing of the samples identified a previously unknown link between specific gut microbiota and atherosclerosis. Treatment with F. prausnitzii may help prevent CAD.
The Impact of Negative and Positive Affectivity on the Relationship Between Work-Related Psychological Factors and Work Engagement in Japanese Workers: A Comparison of Psychological Distress
Authors: Fukuzaki Toshiki , Iwata Noboru 
Published: December 2022

Abstract
Background: A previous study has shown that Japanese individuals generally exhibit behavior that suppresses the expression of positive emotions, which are strongly affected by personality traits. The current study aimed: (a) to determine the extent to which negative or positive affectivity is related to work engagement (WE) and psychological distress among Japanese workers. (b) To determine the extent to which negative and positive affectivity influence the relationship between work-related psychosocial factors and WE and psychological distress.
Methods: A total of 1,000 full-time Japanese regular workers responded to an online survey that measured demographic variables, negative and positive affectivity, job demands and resources, WE, and psychological distress. A hierarchical multiple regression analysis was conducted separately, which used WE and psychological distress as dependent variables.
Results: The proportion of variance explained by negative and positive affectivity was lower for WE than for psychological distress. However, the proportion of variance defined by job demands and resources was higher for WE than for psychological distress. The interaction was only significant for the relationship between negative affectivity and job resources on psychological distress.
Conclusion: The results of this study emphasize the need to focus preferentially work environmental factors to improve WE among Japanese workers. However, workers’ WE would enhance by focusing on individual factors such as affective traits.
Double-tract vs gastric tube reconstruction after proximal gastrectomy in upper third gastric cancer: a Propensity Score Matching Analysis
Authors: Lai Chuilin , Gu Qiou , Zhan Tian , Guan Xiao , Lu Na , Jia Heng , Zhang Jianping 
Published: December 2022

Abstract
Background
With the popularity of function-preserving gastrectomy(FPG) and minimally invasive surgery, proximal gastrectomy(PG) has been widely used in the upper third gastric cancer. There are many reconstruction methods after PG, but the optimal one is still uncertain. The aim of this study is to compare the short-term and long-term outcomes of double-tract reconstruction(DT) and gastric tube reconstruction(Tube) after proximal gastrectomy.
Methods
This study retrospectively reviewed patients who underwent gastrectomy from January 2010 to January 2022 in our hospital. According to the reconstruction method after PG, patients were divided into DT group and Tube group. After adjusting for propensity score matching analysis, we compared the surgical outcomes, complications, and postoperative long-term reflux esophagitis and nutritional status between the two groups.
Result
After propensity score matching had been done, a total of 44 patients were included in this analysis (22 patients in the Tube and DT groups respectively). There were no significance between the two groups in postoperative complications, days of postoperative hospital stay, hemoglobin and albumin decreasing rate at 6 months, and weight loss at 6 and 12 months. The operation time of Tube group was shorter (230 vs 290 min, p = 0.005). The visick score (p = 0.012) and the rate of endoscopic reflux esophagitis (p = 0.001) of DT group were significantly lower .
Conclusion
There is no significance in postoperative complications and nutritional status between double-tract and gastric tube reconstruction after PG. Tube reconstruction can greatly reduce the operation time, while double-tract is more effective in preventing postoperative esophageal reflux.