bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of nurse‐led randomised controlled trials
Authors: Eckert Marion , Kennedy Kate , Neylon Kim , Rickard Claire M. , Keogh Samantha , Gray Richard , Middleton Sandy , Homer Caroline , Whitehead Lisa , Sharplin Greg 
Published: February 2023

AbstractBackgroundNurses comprise the largest portion of the healthcare workforce worldwide. However, nurse representation in the leadership of clinical research and research funding is largely unknown. The Australasian Nursing and Midwifery Clinical Trials Network was established to provide a coordinated network, focussed on building research capacity in nursing and midwifery. To support this work, this scoping review of nurse‐led randomised controlled trials was conducted to summarise research activity, as well as highlight future research directions, gaps and resources. Midwife‐led trials will be reported elsewhere.AimTo quantify number, type and quality of nurse‐led randomised controlled trials registered between 2000–2021.DesignA scoping review of RCTs.Data SourcesMedline, Emcare and Scopus were searched from 2000 to August 2021. ANZCTR, NHMRC, MRFF and HRC (NZ) registries were searched from inception to July 2021.Review MethodsThis review was informed by the JBI scoping review framework using the PRISMA‐ScR.ResultsOur search yielded 188 nurse‐led publications and 279 registered randomised controlled trials. Multiple trials had the same nurse leaders. There were more registrations than publications. Publications were predominantly of high methodological quality; however, there was a reliance on active controls and blinding was low. Trial registrations indicate that universities and hospital/healthcare organisations were the major sources of funding, while publications indicate that Governments and the National Health and Medical Research Council were the main funding bodies.ConclusionA small number of high‐quality, large‐scale, nationally funded randomised controlled trials were identified, with a larger number of locally funded small trials. There was a disparity between the number of registered trials and those published. Additional infrastructure, funding and career frameworks are needed to enable nurses to design, conduct and publish clinical trials that inform the health system and improve health outcomes.Relevance to Clinical PracticeResearch initiated and led by nurses has the potential to improve the health and well‐being of individuals and communities, and current nurse‐led research is of high methodological quality; however, there were very few nurse‐led RCTs, conducted by a small pool of nurse researchers. This gap highlights the need for support in the design, conduct and publishing of nurse‐led RCTs.Patient or Public ContributionThis is a scoping review; therefore, patient or public contribution is not applicable.
Therapeutic effects of L‐arginine, L‐carnitine, and mesenchymal stem cell‐conditioned medium on endometriosis‐induced oocyte poor quality in an experimental mouse model
Authors: Kalehoei Eshrat , Moradi Mojtaba , Azadbakht Mehri , Zhaleh Hossein , Abadi Samaneh Azizi Lal , Mahdiuni Hamid , Gharzi Ahmad 
Published: February 2023

AbstractAimThe present study aimed to explore the potential ameliorative effects of L‐arginine (LA), L‐carnitine (LC), and bone marrow mesenchymal stem cell‐conditioned medium (BMSC‐CM) on endometriosis (EMS) model in vivo and in vitro.MethodsThe animals were divided into two main groups, normal and EMS‐induced mice. Normal and EMS‐induced groups were injected with or without LA (250 mg/kg), LC (250 mg/kg), and BMSC‐CM (a final volume of 100 μL of CM/mouse). At the end of the study, the level of total antioxidant capacity (TAC), nitric oxide (NO), and total oxidative status (TOS) were measured in plasma. Furthermore, immature oocytes were collected from two groups and cultured in a maturation medium. Subsequently, the rates of in vitro maturation, in vitro fertilization (IVF), and in vitro embryonic development were evaluated.ResultsThe results revealed that administration of LA, LC, and BMSC‐CM ameliorated the oxidative status through maintaining TAC and alleviating TOS and NO levels. More importantly, the maturation and fertilization rates, blastocyst development, and total blastocyst cell numbers significantly increased in LA, LC, and BMSC‐CM‐administrated groups compared to the control group. In both the normal and EMS groups, the highest IVF, cleavage, and blastocyst percentages were associated with BMSC‐CM treatment (p < 0.05).ConclusionAltogether, LA, LC, and BMSC‐CM have therapeutic effects on impaired oocyte quality and promote subsequent development in vitro, probably through normalization of nitro‐oxidative stress, thus offering potential alternatives to conventional therapies during assisted reproductive technologies for patients with EMS‐associated sub/infertility.
The effect of different denture cleansing solutions on the retention of polyetheretherketone locator attachments
Authors: Bal Burcu , Erkul Selen , Erzincanlı Ayşe , Ozkurt‐Kayahan Zeynep , Kazazoglu Ender 
Published: February 2023

AbstractPurposeProsthetic cleansing solutions have been reported to cause retention loss in implant locator attachments due to the chemical alterations of these attachments. This study aimed to investigate the effects of different denture cleansing solutions on attachments with different retention values.Materials and methodsIn this study, 160 polyetheretherketone locator attachments were divided into 4 groups according to their attachment retention values (yellow, pink, clear, and violet). Forty attachments from each group were soaked in four different cleansing solutions (n = 10). The attachments from the four groups were immersed in water, sodium hypochlorite, Corega, and Protefix solutions for a period equivalent to 6 months, according to the manufacturer's recommendations. The locator attachments were then subjected to testing using a universal testing machine. Maximum load to dislodgement according to different solutions was evaluated by one‐way ANOVA test. Statistical significance was set at p < 0.05.ResultsThe effect of denture cleansing solutions on the retentive values of attachments was statistically significant (p < 0.001). Among all cleansing solutions, the highest retention value was found in the violet attachments, and the lowest retention value was found in the yellow attachments. The lowest retention value (0.72 ± 0.05 MPa) was observed when the yellow attachments were immersed in Protefix solution, and the highest retention value (1.96 ± 0.15 MPa) was observed when the violet attachments were immersed in the Corega solution.ConclusionFor different colored attachments, different cleansing solutions can be suggested to patients.
Biaxial flexural strength of different provisional restorative materials under chemo‐mechanical aging: An in vitro study
Authors: Sadek Hoda M. Abdel , El‐Banna Ahmed 
Published: February 2023

AbstractPurposeDurability is a critical factor for the success of long‐term provisional restorations. This study evaluated the effect of different storage media and cyclic loading on the biaxial flexural strength of different types of provisional materials.Materials and methodsDiscs (N = 360, 10 × 2 mm) were prepared from different provisional materials; conventional (Protemp 4, Tuff‐Temp, Tempron), CAD–CAM milled (VITA CAD‐Temp, breCAM.multiCOM), and 3D‐printed (Nextdent C&B MFH) (n = 60). Each material group was subdivided into four subgroups according to the storage media (n = 15): nonaged, artificial saliva, mouthwash, and coffee. The specimens in storage media were placed in an incubator at 37°C for 4 weeks followed by 60,000 simulated chewing cycles. Biaxial flexural strength test was done. Data were analyzed using two‐way ANOVA. Weibull distribution parameters were estimated.ResultsBoth the material and aging protocol showed a significant effect on the biaxial flexural strength. Both Protemp 4 and Nextdent C&B MFH showed a significantly higher biaxial flexural strength before and after aging compared to all other materials. Protemp 4 and Tuff Temp showed a significant decrease in strength with aging. CAD–CAM materials showed higher Weibull moduli.ConclusionsThe 3D‐printed polymethylmethacrylate provisional material presents with both greater biaxial flexural strength and increased durability against chemical and mechanical aging compared to conventional and CAD–CAM milled provisional materials tested.
Cross‐cultural sensory and emotions evaluation of chicken‐spice blend by Chinese and Pakistani consumers
Authors: Andaleeb Rani , Chen Yanping , Liu Zhaokun , Zhang Yin , Hussain Muzahir , Lu Yingshuang , Liu Yuan 
Published: February 2023

AbstractThis study is aimed at providing a foundation for the acceptability of two traditional spices (Chinese 5‐spice blend “CS” and garam masala “GM”) in addition to using chicken as a carrier food by Chinese and Pakistani consumers. It can promote ethnic food trading by providing the flavor preferences information of cross‐cultural consumers. Chicken marinated with CS and GM were boiled, and evaluated by consumer hedonic test and Check‐all‐that‐apply sensory and emotion measurements. Results showed the high acceptability of chicken‐spice blend samples, though the drivers of liking between Chinese and Pakistani consumers were varied. Interestingly, chicken‐spice blend samples were recognized for positive emotions, whereas negative emotions were ticked for the least favorite plain chicken sample. Therefore, via the observation and analysis of consumers' behavior in chicken‐spices consumption, our findings may help food researchers and traders understand the perceptions from both countries and thus guide the ethnic food product development in a cross‐cultural context.Practical ApplicationsThis research provides a primary understanding of the flavor perception and acceptability of traditional spices from China and Pakistan by their consumers, which would lead a customer‐centered ethnic food innovation. The implicit needs explored between Chinese and Pakistani consumers for chicken and chicken product consumption would assist in probing the potential market opportunities for ethnic foods trading within and between each country.
Evolution of sleep‐disordered breathing and blood pressure during menopausal transition
Authors: Rimpilä Ville , Lampio Laura , Kalleinen Nea , Vahlberg Tero , Virkki Arho , Saaresranta Tarja , Polo Olli 
Published: February 2023

SummaryThe purpose of this study was to investigate how the blood pressure increase observed during menopausal transition is affected by sleep‐disordered breathing and the menopause itself. Further, we aimed to find new sleep‐disordered breathing related markers that would predict the development of hypertension. Sixty‐four community‐dwelling premenopausal women aged 45–47 years were studied. Polysomnography, serum follicle stimulating hormone, forced expiratory volume in 1 s, and a physical examination were performed at baseline and again after 10 years of follow‐up. Indices for sleep apnea/hypopnea and inspiratory flow‐limitation were determined. Regression models were used to study the relationships between variables. Changes in the apnea‐hypopnea index or serum follicle stimulating hormone were not significant for blood pressure change. An increase in morning blood pressure during the follow‐up period was associated with a body mass‐index increase. An increase in evening blood pressure was associated with an increase in inspiratory flow‐limitation during non‐rapid eye movement sleep. Incident hypertension during the follow‐up was associated with hypopnea (median hypopnea index 7.6/h, p = 0.048) during rapid eye movement sleep at baseline. Users of menopausal hormone therapy had a lower rapid eye movement sleep apnea‐hypopnea index (1.6/h vs. 6.9/h, p = 0.026) at baseline whereas at follow‐up users and non‐users did not differ in any way. The progression of menopause or the use of menopausal hormone therapy had a minimal effect on blood pressure in our population. The effects of inspiratory flow‐limitation on blood pressure profile should be studied further.
Insomnia Severity Index: A reliability generalisation meta‐analysis
Authors: Cerri Luíza Quinália , Justo Mariana Carvalho , Clemente Vanda , Gomes Ana Allen , Pereira Anabela Sousa , Marques Daniel Ruivo 
Published: February 2023

SummaryThe aim of the current study was to conduct a reliability generalisation (RG) meta‐analysis of Cronbachʼs alpha for the Insomnia Severity Index (ISI). A systematic search of three databases (PubMed, Scopus, and Web of Science) from inception to 12 March 2021 was performed. Publications that reported Cronbachʼs alpha for the total ISI score were included. Only psychometric‐focussed studies were considered. Meta‐analysis was carried out using a random‐effects model to derive a pooled estimate of Cronbachʼs alphas. The number of participants in the included publications ranged from 25 to 12,056, with 33 studies (42 estimates) comprising internal consistency coefficients, and a combined sample size of N = 29,688. The age range of the included publications was from 13.4 to 74.3 years. Data extraction implied 33 publications out of 706 found through the database search. Cronbachʼs alphas ranged from 0.65 to 0.92. The majority of the reported coefficients were ≥0.7 and presented a low risk of bias (n = 32). The pooled alpha coefficient was 0.83 (IC [0.81–0.85]; SE = 0.009) with high heterogeneity among the included publications (I2 = 97%). Subgroup analyses including moderators such as continent, setting, risk of bias, and age did not affect significantly the overall result. In general, the cumulative estimate of Cronbachʼs alpha for the ISI is good. However, this finding should be interpreted with caution since there is a high heterogeneity level and some of the studies might not have checked the assumptions underlying Cronbach's alphas.
Brain‐derived neurotrophic factor (BDNF) variants and promoter I methylation are associated with prolonged nocturnal awakenings in older adults
Authors: Ancelin Marie‐Laure , Jaussent Isabelle , Ritchie Karen , Besset Alain , Ryan Joanne , Dauvilliers Yves 
Published: February 2023

SummaryBrain‐derived neurotrophic factor (BDNF) is important for sleep physiology. This study investigates whether BDNF variants and promoter I methylation may be implicated in sleep disturbances in older adults. Genotyping was performed for seven BDNF single nucleotide polymorphisms (SNPs) in 355 community‐dwelling older adults (aged ≥65 years) and BDNF exon 1 promoter methylation was measured in blood samples at baseline (n = 153). Self‐reported daytime sleepiness and insomnia, ambulatory polysomnography measures of sleep continuity and architecture, and psychotropic drug intake were assayed during follow‐up. Logistic regression adjusted for age, sex, comorbidities, body mass index, and psychotropic drug intake. Associations were found specifically between wake time after sleep onset (WASO) and four SNPs in the participants not taking psychotropic drugs, whereas in those taking drugs, the associations were either not significant (rs6265 and rs7103411) or in the reverse direction (rs11030101 and rs28722151). Higher BDNF methylation levels were found at most CpG units in those with long WASO and this varied according to psychotropic drug use. The reference group with short WASO not taking drugs showed the lowest methylation levels and the group with long WASO taking treatment, the highest levels. Some SNPs also modified the associations, the participants carrying the low‐risk genotype having the lower methylation levels. This genetic and epigenetic study demonstrated blood BDNF promoter methylation to be a potential biomarker of prolonged nocturnal awakenings in older people. Our results suggest the modifying effect of psychotropic drugs and BDNF genetic variants in the associations between methylation and WASO.
PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress‐induced hepatocyte pyroptosis
Authors: Tien Shiuan , Zhou Haoxiong , Zhou Qi , Liu Huiling , Wu Bin , Guo Yunwei 
Published: February 2023

AbstractBackground & AimsHeavy drinking is a primary cause of alcoholic liver injury (ALI). Pituitary tumour transforming gene 1 (PTTG1) is involved in the occurrence and development of hepatocellular carcinoma (HCC), which is a well‐known inflammation‐related cancer with various aetiologies, including alcohol consumption. However, the role of PTTG1 in alcohol‐induced liver injury and inflammation is not clear.MethodsBlood samples were collected from patients with acute alcohol intoxication (n = 20) and healthy controls (n = 20). PTTG1 knockout (KO) mice and PTTG1 transgenic (TG) mice were given a single gavage of alcohol (5 g/kg, 50%) to construct the alcohol‐induced liver injury.ResultsWe found that serum PTTG1 levels were downregulated in acute ALI patients. In addition, acute alcohol administration significantly reduced PTTG1 levels in the serum and liver of mice. Compared to wild‐type mice, PTTG1 KO mice had more serious liver injury, which was accompanied by worsened hepatic endoplasmic reticulum (ER) stress and hepatocyte pyroptosis induced by alcohol. Similarly, PTTG1 deficiency exacerbated alcohol‐induced cell death in primary mouse hepatocytes and LO2 cells, by increasing hepatic ER stress and pyroptosis. Importantly, TUDCA, an ER stress inhibitor, could blocked alcohol‐induced hepatic pyroptosis in PTTG1 knockdown LO2 cells. Finally, overexpression of PTTG1 substantially attenuated alcohol‐induced liver injury by reducing ER stress and hepatic pyroptosis in mice.ConclusionsWe demonstrated that PTTG1 participates in ALI and has a protective effect against alcohol‐induced hepatic ER stress and pyroptosis.
Outcomes after liver transplantation using deceased after circulatory death donors: A comparison of outcomes in the UK and the US
Authors: Ivanics Tommy , Claasen Marco P. A. W. , Patel Madhukar S. , Giorgakis Emmanouil , Khorsandi Shirin E. , Srinivasan Parthi , Prachalias Andreas , Menon Krishna , Jassem Wayel , Cortes Miriam , Sayed Blayne A. , Mathur Amit K. , Walker Kate , Taylor Rhiannon , Heaton Nigel , Mehta Neil , Segev Dorry L. , Massie Allan B. , van der Meulen Jan H. P. , Sapisochin Gonzalo , Wallace David 
Published: February 2023

AbstractBackground and AimsIdentifying international differences in utilization and outcomes of liver transplantation (LT) after donation after circulatory death (DCD) donation provides a unique opportunity for benchmarking and population‐level insight.MethodsAdult (≥18 years) LT data between 2008 and 2018 from the UK and US were used to assess mortality and graft failure after DCD LT. We used time‐dependent Cox‐regression methods to estimate hazard ratios (HR) for risk‐adjusted short‐term (0–90 days) and longer‐term (90 days–5 years) outcomes.ResultsOne‐thousand five‐hundred‐and‐sixty LT receipts from the UK and 3426 from the US were included. Over the study period, the use of DCD livers increased from 15.7% to 23.9% in the UK compared to 5.1% to 7.6% in the US. In the UK, DCD donors were older (UK:51 vs. US:33 years) with longer cold ischaemia time (UK: 437 vs. US: 333 min). Recipients in the US had higher Model for End‐stage Liver Disease (MELD) scores, higher body mass index, higher proportions of ascites, encephalopathy, diabetes and previous abdominal surgeries. No difference in the risk‐adjusted short‐term mortality or graft failure was observed between the countries. In the longer‐term (90 days–5 years), the UK had lower mortality and graft failure (adj.mortality HR:UK: 0.63 (95% CI: 0.49–0.80); graft failure HR: UK: 0.72, 95% CI: 0.58–0.91). The cumulative incidence of retransplantation was higher in the UK (5 years: UK: 11.9% vs. 4.6%; p < .001).ConclusionsFor those receiving a DCD LT, longer‐term post‐transplant outcomes in the UK are superior to the US, however, significant differences in recipient illness, graft quality and access to retransplantation were seen between the two countries.
A repeated cross‐sectional analysis of the Icelandic baby food market surveyed in 2016, 2019 and 2021
Authors: Thorisdottir Birna , Odinsdottir Tinna , Thorsdottir Inga 
Published: February 2023

AbstractWorld Health Organisation (WHO) has stated that countries need to know their local commercial baby food (CBF) market. Data from other countries suggest rapid changes in CBF options, highlighting the need for repeated analysis. In that context, this repeated cross‐sectional study analysed the options and nutrient quality of different CBF types available in Iceland in years 2016, 2019 and 2021. Data was gathered on formulas, porridge flours, foods in jars and pouches, finger‐foods, other CBF. They were classified into 26 subgroups based on ingredients and taste (sweet/savoury). Minimum consumer age as suggested by the manufacturers and nutritional content were registered. In each data‐collection, 250–275 products were available. Over a third of products (37%–44%) were in pouches. Availability of products intended for 4–11‐month‐old infants decreased, driven largely by a 65% decrease in availability of food in jars (sweet/savoury) between 2016 and 2021. Availability of products intended from 12+ months or without age‐labels increased, driven largely by quadrupling of finger‐foods (predominantly sweet) between 2016 and 2021. The overall percentage of products classified as sweet increased from 65% (2016) to 73% (2019) and 77% (2021). Some finger‐foods had high sugar content (up to 72 g/100 g), partly from fruit concentrate or sugar/syrup. Like other countries, the Icelandic CBF market has moved towards less availability of food intended in the first year and more availability of sweet finger‐foods for an expanded consumer age. As sugar is added to some CBF, stronger regulations on promotion of foods for young consumers and updated recommendations for parents/caregivers may be needed.
Being as Communion in Aquinas’s Trinitarian Theology
Authors: Higgins Michael Joseph 
Published: February 2023

AbstractA number of thinkers in recent decades have argued that, in light of the Trinity, we can see that God's being is communion. Particularly effective was John D. Zizioulas, whose Trinitarian ontology centered on communion. Some skeptical of this claim have invoked Aquinas as a source for countering an ontology of communion. I argue that, while Thomas never explicitly affirms that the divine being is communion, he can give us deep resources for reaching this conclusion. Indeed, he can ultimately lead us towards a divine being which is more thoroughly a matter of communion—and towards an ontology which is more radically Trinitarian—than anything we find in Zizioulas.
Paschal Triduum
Authors: McCabe Herbert 
Published: February 2023

AbstractHere New Blackfriars is publishing for the first time a set of three talks given in 1979 by the distinguished Dominican theologian Herbert McCabe (1926-2001). It appears that the talks were delivered in Leeds, UK, during a Holy Week retreat (or something like that). The text below derives from a typescript put together by someone unknown on the basis of what seems to have been an audio recording. McCabe is clearly drawing on these talks in Chapters 7 to 9 of his 1987 book God Matters (chapters which are reprints of articles published in New Blackfriars in 1986). However, the original talks as they appear below have the brevity, freshness, informality, spontaneity, and blemishes characteristic of a ‘live performance’ rather than a reworking and development of them for publication coming seven years after they were delivered. That is why New Blackfriars is now publishing them in the hope that they might interest readers of the journal, which McCabe edited for many years. New Blackfriars is grateful to Marie Turner for drawing its attention to them and for sending it a copy of the typescript of the 1979 talks.