bluuebunny/crossref_metadata_2025_split huggingface dataset:
One-dimensional full-waveform inversion for magnetic induction data in ground-based transient electromagnetic methods
Authors: Li Jianhui , Wang Xingchun , Hu Xiangyun , Cai Hongzhu , Zhi Qingquan , Chen Shi 
Published: April 2023

Abstract
The full-waveform effects refer to the total effects of turn-on, steady and turn-off durations for a transmitting-current waveform as well as its repetition number in transient electromagnetic (TEM) methods. In this study, the full-waveform effects are investigated using both forward-modeling and inversion methods considering typical background noise. The forward-modeling results of homogeneous half-space models show that the magnetic induction, bz, is less affected by the background noise but more affected by the full-waveform effects than the time derivative of magnetic induction ∂bz/∂t. Therefore, this study focuses on investigating the full-waveform effects on bz. The inversion results for synthetic and field examples show that the inversion algorithm without considering the full-waveform effects leads to over-estimated resistivities in deeper parts of the recovered models compared to the true model. As a result, it is crucial to consider the full-waveform effects when processing TEM data. Furthermore, a standard deviation factor (STDF) is estimated for model parameters of the inversion. The results show that the STDF increases as the layer depth increases for 1D layered models. This indicates that the inverted parameters are well resolved for shallower layers and moderately to poorly resolved for deeper layers.
The role of γδ T cells in the immunopathogenesis of inflammatory diseases: from basic biology to therapeutic targeting
Authors: Bernal-Alferes Brian , Gómez-Mosqueira Rafael , Ortega-Tapia Graciela Teresa , Burgos-Vargas Rubén , García-Latorre Ethel , Domínguez-López María Lilia , Romero-López José Pablo 
Published: April 2023

Abstract
The γδ T cells are lymphocytes with an innate-like phenotype that can distribute to different tissues to reside and participate in homeostatic functions such as pathogen defense, tissue modeling, and response to stress. These cells originate during fetal development and migrate to the tissues in a TCR chain–dependent manner. Their unique manner to respond to danger signals facilitates the initiation of cytokine-mediated diseases such as spondyloarthritis and psoriasis, which are immune-mediated diseases with a very strong link with mucosal disturbances, either in the skin or the gut. In spondyloarthritis, γδ T cells are one of the main sources of IL-17 and, therefore, the main drivers of inflammation and probably new bone formation. Remarkably, this population can be the bridge between gut and joint inflammation.
Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites
Authors: Ning Wei , Wu Tao , Wu Chenxu , Wang Shixiang , Tao Ziyu , Wang Guangshuai , Zhao Xiangyu , Diao Kaixuan , Wang Jinyu , Chen Jing , Chen Fuxiang , Liu Xue-Song 
Published: April 2023

AbstractDNA methylation analysis has been applied to determine the primary site of cancer; however, robust and accurate prediction of cancer types with a minimum number of sites is still a significant scientific challenge. To build an accurate and robust cancer type prediction tool with a minimum number of DNA methylation sites, we internally benchmarked different DNA methylation site selection and ranking procedures, as well as different classification models. We used The Cancer Genome Atlas dataset (26 cancer types with 8296 samples) to train and test models and used an independent dataset (17 cancer types with 2738 samples) for model validation. A deep neural network model using a combined feature selection procedure (named MethyDeep) can predict 26 cancer types using 30 methylation sites with superior performance compared with the known methods for both primary and metastatic cancers in independent validation datasets. In conclusion, MethyDeep is an accurate and robust cancer type predictor with the minimum number of DNA methylation sites; it could help the cost-effective clarification of cancer of unknown primary patients and the liquid biopsy-based early screening of cancers.
Estimating human papillomavirus vaccine efficacy from a single-arm trial: proof-of-principle in the Costa Rica Vaccine Trial
Authors: Befano Brian , Campos Nicole G , Egemen Didem , Herrero Rolando , Schiffman Mark , Porras Carolina , Lowy Douglas R , Rodriguez Ana Cecilia , Schiller John T , Ocampo Rebecca , Hildesheim Allan , Sampson Joshua N , Das Shrutikona , Kreimer Aimée R , Cheung Li C ,   for the Costa Rica HPV Vaccine Trial (CVT) Group, Cortés Bernal , González Paula , Herrero Rolando , Jiménez Silvia E , Porras Carolina , Rodríguez Ana Cecilia , Hildesheim Allan , Kreimer Aimée R , Lowy Douglas R , Schiffman Mark , Schiller John T , Sherman Mark , Wacholder Sholom , Pinto Ligia A , Kemp Troy J , Sidawy Mary K , Quint Wim , van Doorn Leen-Jan , Struijk Linda , Palefsky Joel M , Darragh Teresa M , Stoler Mark H 
Published: April 2023

AbstractBackgroundThe World Health Organization recommends a 1- or 2-dose human papillomavirus (HPV) vaccination schedule for females aged 9 to 20 years. Studies confirming the efficacy of a single dose and vaccine modifications are needed, but randomized controlled trials are costly and face logistical and ethical challenges. We propose a resource-efficient single-arm trial design that uses untargeted and unaffected HPV types as controls.MethodsWe estimated HPV vaccine efficacy (VE) from a single arm by comparing 2 ratios: the ratio of the rate of persistent incident infection with vaccine-targeted HPV 16 and 18 (HPV 16/18) and cross-protected types HPV 31, 33, and 45 (HPV 31/33/45) to vaccine-unaffected types HPV 35, 39, 51, 52, 56, 58, 59, and 66 (HPV 35/39/51/52/56/58/59/66) vs the ratio of prevalence of these types at the time of trial enrollment. We compare VE estimates using only data from the bivalent HPV 16/18 vaccine arm of the Costa Rica Vaccine Trial with published VE estimates that used both the vaccine and control arms.ResultsOur single-arm approach among 3727 women yielded VE estimates against persistent HPV 16/18 infections similar to published 2-arm estimates from the trial (according-to-protocol cohort: 91.0% , 95% CI = 82.9% to 95.3% [single-arm] vs 90.9% , 95% CI = 82.0% to 95.9% [2-arm]; intention-to-treat cohort: 41.7%, 95% CI = 32.4% to 49.8% [single-arm] vs 49.0% , 95% CI = 38.1% to 58.1% [2-arm]). VE estimates were also similar in analytic subgroups (number of doses received; baseline HPV serology status).ConclusionsWe demonstrate that a single-arm design yields valid VE estimates with similar precision to a randomized controlled trial. Single-arm studies can reduce the sample size and costs of future HPV vaccine trials while avoiding concerns related to unvaccinated control groups.Trial registrationClinicalTrials.gov Identifier: NCT00128661.
Low clinical sensitivity and unexpectedly high incidence for neuropathologically diagnosed progressive supranuclear palsy
Authors: Driver-Dunckley Erika D , Zhang Nan , Serrano Geidy E , Dunckley Nathaniel A , Sue Lucia I , Shill Holly A , Mehta Shyamal H , Belden Christine , Tremblay Cecilia , Atri Alireza , Adler Charles H , Beach Thomas G 
Published: April 2023

Abstract
The objective of this study was to determine the prevalence, incidence, and clinical diagnostic accuracy for neuropathologically diagnosed progressive supranuclear palsy (PSP) with data from a longitudinal clinicopathological study using Rainwater criteria to define neuropathological PSP. Of 954 autopsy cases, 101 met Rainwater criteria for the neuropathologic diagnosis of PSP. Of these, 87 were termed clinicopathological PSP as they also had either dementia or parkinsonism or both. The prevalence of clinicopathologically defined PSP subjects in the entire autopsy dataset was 9.1%, while the incidence rate was estimated at 780 per 100 000 persons per year, roughly 50-fold greater than most previous clinically determined PSP incidence estimates. A clinical diagnosis of PSP was 99.6% specific but only 9.2% sensitive based on first examination, and 99.3% specific and 20.7% sensitive based on the final clinical exam. Of the clinicopathologically defined PSP cases, 35/87 (∼40%) had no form of parkinsonism at first assessment, while this decreased to 18/83 (21.7%) at final assessment. Our study confirms a high specificity but low sensitivity for the clinical diagnosis of PSP. The low clinical sensitivity for PSP is likely primarily responsible for previous underestimates of the PSP population incidence rate.
Double perinatal stress reduces the sexual response of adult female Wistar rats
Authors: Ferraz Marcos Rochedo , Cavalheira Mariana Alencar , Macena de Santana Amanda O , Barboza Vanessa Nascimento , da Silva Nântua Mariana , Santos Larissa Nascimento , Pereira Sabrina 
Published: April 2023

AbstractBackgroundEarly-life stress affects physiological development and produces changes in various aspects of emotional behavior.AimWe sought to examine the effects of double perinatal stress (DPS)—a combination of prenatal systemic hypoxic-ischemic (HI) insults and repeated early maternal separation—on the estrus cycle and sexual behavior of adult rats.MethodsHI was induced by clamping the uterine arteries of pregnant rats for 45 minutes on the 18th day of gestation (HI group). Sham control animals received laparotomy and anesthesia only. Pups were born at term. Maternal separation was performed from postnatal day 1 (P1) (P0 = day of birth) to P15. At P90, the sexual response of females in estrus was evaluated. Statistical analysis was performed using 2-way analysis of variance followed by Tukey’s test.OutcomesWe considered the estrous cycle and sexual behavior of female rats submitted to DPS, as well as the influence of female behavior on the sexual response of male rats.ResultsRats submitted to DPS showed a reduction in the lordosis quotient and in the lordosis rate, suggesting a reduction in female sexual receptivity. DPS female rats showed a reduction in the number of hops and darts and in the genital exploration time rate, suggesting a reduction in sexual proceptivity. In addition, males that interacted with DPS females showed a reduction in the number of ejaculations and in copulatory efficiency.Clinical ImplicationsDeveloping a deeper understanding of perinatal factors that affect adult female sexual response will allow for more effective interventions to prevent and treat such changes. On the other hand, the analysis of the sexual response allows assessing the quality of life and the general state of health.Strengths and LimitationsThe development of animal models to investigate the environmental factors that interfere in the female sexual response may allow researchers to propose and test new therapeutic strategies. On the other hand, care must be exercised when interpreting animal data and extrapolating these results to estimate the possible effects of perinatal stressors on the human sexual response.ConclusionOur results revealed that females subjected to DPS showed long-term effects on sexual behavior. In conclusion, managing stressors in prenatal life and early postnatal life can prevent problems in adult sexual life and improve overall health.
Simplified regional citrate anticoagulation protocol for CVVH, CVVHDF and SLED focused on the prevention of KRT-related hypophosphatemia while optimizing acid-base balance
Authors: Di Mario Francesca , Sabatino Alice , Regolisti Giuseppe , Pacchiarini Maria Chiara , Greco Paolo , Maccari Caterina , Vizzini Giuseppe , Italiano Chiara , Pistolesi Valentina , Morabito Santo , Fiaccadori Enrico 
Published: April 2023

ABSTRACT

Background
Hypophosphatemia is a common electrolyte disorder in critically ill patients undergoing prolonged kidney replacement therapy (KRT). We evaluated the efficacy and safety of a simplified regional citrate anticoagulation (RCA) protocol for continuous venovenous hemofiltration (CVVH), continuous venovenous hemodiafiltration (CVVHDF) and sustained low-efficiency dialysis filtration (SLED-f). We aimed at preventing KRT-related hypophosphatemia while optimizing acid-base equilibrium.

Methods
KRT was performed by the Prismax system (Baxter) and polyacrylonitrile AN69 filters (ST 150, 1.5 m2, Baxter), combining a 18 mmol/L pre-dilution citrate solution (Regiocit 18/0, Baxter) with a phosphate-containing solution (HPO42− 1.0 mmol/L, HCO3− 22.0 mmol/L; Biphozyl, Baxter). When needed, phosphate loss was replaced with sodium glycerophosphate pentahydrate (Glycophos™ 20 mmol/20 mL, Fresenius Kabi Norge AS, Halden, Norway). Serum citrate measurements were scheduled during each treatment. We analyzed data from three consecutive daily 8-h SLED-f sessions, as well as single 72-h CVVH or 72-h CVVHDF sessions. We used analysis of variance (ANOVA) for repeated measures to evaluate differences in variables means (i.e. serum phosphate, citrate). Because some patients received phosphate supplementation, we performed analysis of covariance (ANCOVA) for repeated measures modelling phosphate supplementation as a covariate.

Results
Forty-seven patients with acute kidney injury (AKI) or end stage kidney disease (ESKD) requiring KRT were included [11 CVVH, 11 CVVHDF and 25 SLED-f sessions; mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score 25 ± 7.0]. Interruptions for irreversible filter clotting were negligible. The overall incidence of hypophosphatemia (s-P levels &lt;2.5 mg/dL) was 6.6%, and s-P levels were kept in the normality range irrespective of baseline values and the KRT modality. The acid-base balance was preserved, with no episode of citrate accumulation.

Conclusions
Our data obtained with a new simplified RCA protocol suggest that it is effective and safe for CVVH, CVVHDF and SLED, allowing to prevent KRT-related hypophosphatemia and maintain the acid-base balance without citrate accumulation.

Trial registration
NCT03976440 (registered 6 June 2019)
Systemic immune derangements are shared across various CNS pathologies and reflect novel mechanisms of immune privilege
Authors: Lorrey Selena J , Waibl Polania Jessica , Wachsmuth Lucas P , Hoyt-Miggelbrink Alexandra , Tritz Zachariah P , Edwards Ryan , Wolf Delaney M , Johnson Aaron J , Fecci Peter E , Ayasoufi Katayoun 
Published: April 2023

AbstractBackgroundThe nervous and immune systems interact in a reciprocal manner, both under physiologic and pathologic conditions. Literature spanning various CNS pathologies including brain tumors, stroke, traumatic brain injury and de-myelinating diseases describes a number of associated systemic immunologic changes, particularly in the T-cell compartment. These immunologic changes include severe T-cell lymphopenia, lymphoid organ contraction, and T-cell sequestration within the bone marrow.MethodsWe performed an in-depth systematic review of the literature and discussed pathologies that involve brain insults and systemic immune derangements.ConclusionsIn this review, we propose that the same immunologic changes hereafter termed ‘systemic immune derangements’, are present across CNS pathologies and may represent a novel, systemic mechanism of immune privilege for the CNS. We further demonstrate that systemic immune derangements are transient when associated with isolated insults such as stroke and TBI but persist in the setting of chronic CNS insults such as brain tumors. Systemic immune derangements have vast implications for informed treatment modalities and outcomes of various neurologic pathologies.
Burden of dental caries in individuals experiencing food insecurity: a systematic review and meta-analysis
Authors: Drumond Victor Z , de Arruda José Alcides A , Bernabé Eduardo , Mesquita Ricardo A , Abreu Lucas G 
Published: April 2023

Abstract

Context
Food insecurity affects approximately 2.37 billion people worldwide. Individuals experiencing food insecurity are more likely to exhibit poor health-related endpoints. Dental caries, a highly prevalent noncommunicable disease, is modulated by an interplay between biological, behavioral, and environmental factors.

Objective
This systematic review and meta-analysis aimed to assess whether individuals experiencing food insecurity were more likely to exhibit dental caries than individuals facing food security.

Data Sources
The Web of Science, PubMed, Scopus, Embase, Ovid, CINAHL, LILACS, and APA PsycINFO databases were checked from inception to November 2021. Grey literature and Google Scholar were also examined. An updated search was conducted in August 2022. Observational studies were included if they evaluated the association between dental caries and food insecurity status.

Data Extraction
Data extraction was performed by two reviewers.

Data Analysis
Random-effects meta-analyses were conducted using R language. In total, 514 references were retrieved from databases, of which 14 articles were included in qualitative synthesis and 7 were merged into meta-analysis. The results of an inverse-variance meta-analysis (OR = 1.62; 95%CI, 1.01–2.60) and a meta-analysis of binary data (OR = 1.66; 95%CI, 1.36–2.02) demonstrated that food-insecure individuals were more likely to exhibit dental caries than food-secure individuals. Inverse-variance meta-analyses appraising multiple strata of food security also showed that individuals experiencing marginal food security (OR = 1.48; 95%CI, 1.28–1.72), individuals experiencing low food security (OR = 1.26; 95%CI, 1.01–1.57), and those experiencing very low food security (OR = 1.33; 95%CI, 1.04–1.71) were more likely to exhibit dental caries than individuals experiencing full food security.

Conclusion
Dental caries is associated with food insecurity. Individuals living with food insecurity are more likely to exhibit dental caries than those who have food security.

Systematic Review Registration
PROSPERO registration number CRD42021268582.
Containment of a Verona Integron-Encoded Metallo-Beta-Lactamase-Producing Pseudomonas aeruginosa Outbreak Associated With an Acute Care Hospital Sink—Tennessee, 2018–2020
Authors: Chan Allison , Thure Katie , Tobey Kelley , Shugart Alicia , Schmedes Sarah , Burks James Albert , Hardin Henrietta , Moore Christina , Carpenter Tina , Brooks Stephanie , Gable Paige , Moulton Meissner Heather , McAllister Gillian , Lawsin Adrian , Laufer Halpin Alison , Spalding Walters Maroya , Keaton Amelia 
Published: April 2023

Abstract

Background
Contaminated healthcare facility wastewater plumbing is recognized as a source of carbapenemase-producing organism transmission. In August 2019, the Tennessee Department of Health (TDH) identified a patient colonized with Verona integron-encoded metallo-beta-lactamase-producing carbapenem-resistant Pseudomonas aeruginosa (VIM-CRPA). A record review revealed that 33% (4 of 12) of all reported patients in Tennessee with VIM had history of prior admission to acute care hospital (ACH) A intensive care unit (ICU) Room X, prompting further investigation.

Methods
A case was defined as polymerase chain reaction detection of blaVIM in a patient with prior admission to ACH A from November 2017 to November 2020. The TDH performed point prevalence surveys, discharge screening, onsite observations, and environmental testing at ACH A. The VIM-CRPA isolates underwent whole-genome sequencing (WGS).

Results
In a screening of 44% (n = 11) of 25 patients admitted to Room X between January and June 2020, we identified 36% (n = 4) colonized with VIM-CRPA, resulting in 8 cases associated with Room X from March 2018 to June 2020. No additional cases were identified in 2 point-prevalence surveys of the ACH A ICU. Samples from the bathroom and handwashing sink drains in Room X grew VIM-CRPA; all available case and environmental isolates were found to be ST253 harboring blaVIM-1 and to be closely related by WGS. Transmission ended after implementation of intensive water management and infection control interventions.

Conclusions
A single ICU room's contaminated drains were associated with 8 VIM-CRPA cases over a 2-year period. This outbreak highlights the need to include wastewater plumbing in hospital water management plans to mitigate the risk of transmission of antibiotic-resistant organisms to patients.
The International Monetary Fund and capital flows
Authors: Grenville Stephen 
Published: April 2023

AbstractControls on international capital flows were a central issue for the International Monetary Fund at Bretton Woods in 1944. But by the 1970s, mainstream thinking was encouraging open capital flows. A succession of damaging crises followed: Latin America in the 1980s, Mexico again in 1994, and Asia in 1997. Fund policies were tweaked, but the causes were seen as being largely in the recipient countries. Capital controls were specifically rejected.Nevertheless, the Fund’s view began to shift, probably encouraged by the 2008 global financial crisis. There was a growing recognition that the capital-flow surges at the heart of these crises were often externally driven, reflecting global factors. The appropriate response would include capital flow management (CFM). The Fund recognized this in its 2012 Institutional View, but CFM was at the bottom of the policy toolbox, surrounded by conditions and constraints, maintaining the stigma on CFM.Meanwhile many emerging economies were enhancing their ability to cope with excessive capital flows, although at some cost (slower growth, tighter fiscal policy, large foreign-exchange reserves). At the same time the flows were increasing, with a bigger component of flighty portfolio flows. CFM measures still have an important place in this new environment, but the Fund’s reluctance to embrace them means that a deep discussion on operationalizing effective CFMs is still lacking.
Avoiding a lost decade—an interim update
Authors: Buchheit Lee C , Gulati Mitu 
Published: April 2023

AbstractAll sovereign debt restructurings are inherently messy, expensive, exasperating, time-consuming, and contentious. These are the familiar pathologies in the international system to resolve unsustainable sovereign debts. But the period since the onset of the Covid-19 crisis has revealed (to use a term we all learned during pandemic lockdowns) several new co-morbidities. These include a breakdown in the ability of the major external creditor groups (traditional Paris Club lenders, non-Paris Club bilateral creditors like China and bondholders) to coordinate their debt relief efforts, the increasingly diverse nature of the private-sector entities holding claims against a debtor state, and the total absence of any mechanisms—statutory or contractual—that can be used to ensure that the sacrifices made by the vast majority of claimants and official sector sponsors in the economic recovery process cannot be exploited by the uncooperative few.
Hyponastic Leaves 1 Interacts with RNA Pol II to Ensure Proper Transcription of MicroRNA Genes
Authors: Bielewicz Dawid , Dolata Jakub , Bajczyk Mateusz , Szewc Lukasz , Gulanicz Tomasz , Bhat Susheel S , Karlik Anna , Jozwiak Monika , Jarmolowski Artur , Szweykowska-Kulinska Zofia 
Published: April 2023

Abstract
Hyponastic Leaves 1 (HYL1) [also known as Double-stranded RNA-Binding protein 1 (DRB1)] is a double-stranded RNA-binding protein involved in microRNA (miRNA) processing in plants. It is a core component of the Microprocessor complex and enhances the efficiency and precision of miRNA processing by the Dicer-Like 1 protein. In this work, we report a novel function of the HYL1 protein in the transcription of miRNA (MIR) genes. HYL1 colocalizes with RNA polymerase II and affects its distribution along MIR genes. Moreover, proteomic experiments revealed that the HYL1 protein interacts with many transcription factors. Finally, we show that the action of HYL1 is not limited to MIR genes and impacts the expression of many other genes, a majority of which are involved in plastid organization. These discoveries indicate HYL1 as an additional player in gene regulation at the transcriptional level, independent of its role in miRNA biogenesis.