bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced Level of Prolylhydroxyproline in the Nail Clippings of Oral Cancer
Patients and its Role as an Activator of Phospholipase C-β2
Authors: Bhatkar Devyani , Nimburkar Dipti , Raj Ajay Kumar , Lokhande Kiran B. , Khunteta Kratika , Kothari Haet , Joshi Mrudula , Sarode Sachin C. , Sharma Nilesh Kumar 
Published: August 2023

Background:
The oral cancer microenvironment plays an important role in the development
and progression of the disease which depicts the heterogeneous nature of diseases. Several
cellular and non-cellular factors, including dipeptides, have been reported to drive tumor progression
and metastasis. Among various secreted molecules in the tumor microenvironment, prolylhydroxyproline
(Pro-Hyp) is a collagen-degraded product with specific relevance to fibrosis and oral
cancer. However, the detection of Pro-Hyp in the nails of oral cancer patients is a potential biomarker,
and our understanding of the biological relevance of Pro-Hyp is highly limited.

Methods:
Here, the authors have attempted to use a novel and in-house vertical tube gel electrophoresis
(VTGE) protocol to evaluate the level of Pro-Hyp in the nails of oral cancer patients
and healthy subjects. Furthermore, we employed molecular docking and molecular dynamics (MD)
simulations to predict the biological function of Pro-Hyp. ADME profiles such as the druglikeness
and leadlikeness of Pro-Hyp and a known PLC-β2 activator, m-3M3FBS, were evaluated by the
SWISS-ADME server.

Results:
We report that among various key metabolites, Pro-Hyp, a dipeptide, is reduced in the
nails of oral cancer patients. Molecular docking and MD simulations helped to suggest the potential
role of Pro-Hyp as an activator of Phospholipase C-β2 (PLC-β2). Pro-Hyp displayed good binding
affinity (-7.6 kcal/mol) with specific interactions by a conventional hydrogen bond with key
residues, such as HIS311, HIS312, VAL641, and GLU743. MD simulations showed that the activator
binding residues and stability of complexes are similar to the well-known activator m-3M3FBS
of PLC-β2. ADME profiles such as the druglikeness and leadlikeness of Pro-Hyp were found to be
highly comparable and even better than those of m-3M3FBS.

Conclusion:
This study is one of the first reports on Pro-Hyp as a metabolite biomarker in the nails
of oral cancer patients. Furthermore, the implications of Pro-Hyp are proposed to activate PLC-β2
as a pro-tumor signaling cascade. In the future, diagnostic and therapeutic approaches may be explored
as biomarkers and mimetic of Pro-Hyp.
How to Modulate Peripheral and Central Nervous System to Treat Acute
Postoperative Pain and Prevent Pain Persistence
Authors: Cazzaniga Sara , Real Giovanni , Finazzi Simone , Lorini Luca F. , Forget Patrice , Bugada Dario 
Published: August 2023

Abstract:
Chronic postoperative pain (CPSP) is a major issue after surgery, which may impact on patient’s
quality of life. Traditionally, CPSP is believed to rely on maladaptive hyperalgesia and risk factors
have been identified that predispose to CPSP, including acute postoperative pain. Despite new
models of prediction are emerging, acute pain is still a modifiable factor that can be challenged with
perioperative analgesic strategies. In this review we present the issue of CPSP, focusing on molecular
mechanism underlying the development of acute and chronic hyperalgesia. Also, we focus on how
perioperative strategies can impact directly or indirectly (by reducing postoperative pain intensity) on
the development of CPSP.
The Evaluation of Subcutaneous and Visceral Adipose Tissue Changes by
Computed Tomography in Coronavirus Disease 2019 and Comparison with
Quantitative Analysis of Lung Involvement
Authors: Vural Murat , Akdal Dolek Betul , Ucar Ozgul , Ozkan Erdem , Eren Ozkaya Utku 
Published: August 2023

Background:
This study aims to reveal the relationship between lung involvement and visceral adipose tissue changes between chest-computed tomography (CT) scans taken in short intervals in COVID-19 patients.

Methods:
The retrospective study included 52 patients who tested positive for SARS-CoV-2. All patients had two chest CT exams. Lung involvement measurements were calculated by using an artificial intelligence tool. Visceral and subcutaneous fat tissue was measured at the level of the first lumbar vertebra on chest CT. Additionally, demographic and laboratory data were collected.

Results:
52 patients were included (36.5 % female, mean age 50). Visceral fat area and visceral fat thickness changes were significantly positive predictors of total lung involvement changes (p=0.033, p=0.00024). Subcutaneous fat area and subcutaneous fat thickness changes were not associated with lung involvement change (p>0.05). CRP, IL-6, d-dimer, and ferritin levels were higher in patients who need intensive care units.

Conclusion:
Visceral adipose tissue changes may indicate that it can have a role as a reservoir of virus involvement.
Evaluation of the Implementation of the Family Hope Program (PKH) in the Education Sector in Nagari Guguak Tabek Sarajo, IV Koto District, Agam Regency
Authors: Fitri Aditiya , Natsir MHD , Jalius Jalius 
Published: August 2023

Lack of collaboration is what inspired this study between groups of recipients of PHK assistance, lack of supervision from government agencies towards the community, lack of realization of layoff funds for educational purposes. So that the general purpose of this study focuses on the implementation of the family of hope program in the field of education in the country of Guguak Tabek Sarojo . the specific objective is to see the evaluation of the family of hope program in the countryof Guguak Tabek Sarojo. This research is a qualitative descriptive type with the research location in Nagari Guguak Tabek Sarajo IV Koto district, Agam Regency. Collection techniques used observation interviews and recording. Analysis techniques used reduction, presentation and inference extraction or confirmation. The findings obtained are that (1) this layoff assistance can increase human resources so as to improve the quality of education for the lower middle class community, (2) program planning in the evaluation of implementation, (3) formative evaluation of program implementation in the education sector has been carried out although there are still few the obstacles experienced (4) the achievement of the summative program in education can be seen from the positive response of the people who receive layoff assistance. It is recommended that the persons in charge work together and coordinate with each other and charge to make a clear structure explaining their respective responsibilities. Keywords: Evaluation, Program, Education, PKH
The Relationship between Pedagogical Competencies Educators and the Discipline of Students in Surau Tahfidz Al Jihad Jorong Salimpek Solok Regency
Authors: Warzukni Warzukni , Setiawati Setiawati 
Published: August 2023

This research is motivated by using the low subject of college students at Surau Tahfidz Al Jihad Jorong Salimpek. Allegedly because of the low pedagogic competence of educators. The aims of this study were to: (1) see the outline of the pedagogical competence of educators at Surau Tahfidz Al Jihad (2), see the outline of pupil subject at Surau Tahfidz Al Jihad and (3) discover the connection between the pedagogical competence of educators and the subject of students at Surau Tahfidz Al Jihad. This form of studies is descriptive correlational with a quantitative technique. The populace of this take a look at was fifty six humans and a sample of 28 humans with stratified random sampling technique. The data series method is a questionnaire and the tool used is a questionnaire. The information analysis approach used the proportion formulation and the spearman rho formula. The outcomes of this have a look at suggest that: 1) the pedagogical competence of educators at Surau Tahfidz Al Jihad is low, 2) the subject of students at Surau Tahfidz Al Jihad is low, and three) there's a great courting between the pedagogical competence of educators and the gaining knowledge of area of college students in Surau. Tahfidz Al Jihad. The thought of this research is that the Surau Tahfidz Al Jihad educators must be capable of improve their pedagogical competence. it's miles hoped that the manager will provide steering and development of the pedagogic competence of educators at Surau Tahfidz Al Jihad.
The Relationship Between Parental Support and Entrepreneurial Interest Graduates of Fashion Design Training at the Women's Skills Institute Modeste Dolly
Authors: Syafitri Febby , Natsir MHD. 
Published: August 2023

This research isimotivated by the low interest in entrepreneurship graduates from fashion training at LKW Modeste Dolly. This is thought to be influenced by parental support in terms of entrepreneurship. This study aims to: (1) describe parental support for LKW Modeste Dolly fashion training graduates; (2) describe entrepreneurial interest for LKW Modeste Dolly fashion training graduates; and (3) examine the relationship between support and interest in entrepreneurship for LKW Modeste Dolly fashion training graduates. This study is a quantitative correlational type with a sample size of 75% of the population and a population of 40 persons is taken so that 30 respondents are obtained. This study shows the results, namely: (1) parental support for fashion design training graduates at LKW Modeste Dolly is categorized as low; (2) the entrepreneurial interest of graduates from fashion training at LKW Modeste Dolly is categorized as low; (3) Parental support and interest in entrepreneurship are positively and significantly correlated for graduates of fashion training at LKW Modeste Dolly.
Strapping Rope Skills Training for Housewives to Utilize Free Time In Tualang Village, Siak District
Authors: Aldestu Agnesiyah Sumbari , Jamaris Jamaris 
Published: August 2023

This research is inspired with the aid of housewives who take benefit in their free time by means of processing strong waste into multipurpose items. The aim is to improve the abilities of housewives through training sports so we can boom know-how, increase circle of relatives earnings and enhance the welfare of the Tualang Village network. The purpose of this have a look at is to explain the education of woven strapping talents in phrases of the process, blessings, as well as supporting and inhibiting elements in accomplishing education. This research is a research the use of a qualitative method, with the studies method is a case study. The records assets in this examine had been housewives in Tualang Village who were members of the Tunas Harapan IKM as research subjects and the top of the Tunas Harapan IKM as studies informants. information series strategies used on this observe are observation, interviews and documentation. The information analysis approach used is data reduction, facts presentation and drawing conclusions. The information validity method is by using the usage of source triangulation. The effects showed that the capabilities schooling manner began from planning, implementation, mentoring, evaluation, and follow-up, the benefits of education in terms of information, independence and cooperation, helping factors, namely fine responses from contributors, lively participation chairperson, availability of substances and support from family and friends who assist every other. while the inhibiting thing is the cloth received is less. Keywords: Training, Strapping Webbing Skills for Housewives
Generative AI and education ecologies
Authors: Coleman Kathryn 
Published: August 2023

What role can generative AI have an art and design education? Given that we are in a year of change as open-source Open AI systems shift how we teach, learn, and assess in times of question-answering chatbot and personal assistance tools. Applying a post-human approach (Blaikie, et al, 2020) to education might help us rethink pedagogy (Wessels, et al, 2022), knowledge creation and scholarly publication for knowledge sharing. In this SoTEL Symposium presentation/discussion with the ASCILITE MLSIG I propose a move away from a humanist world view that continues to shape our thoughts around the binary of teacher-learner within our walled disciplinary and consider how we might Incorporate generative AI tools in the curriculum to foster interdisciplinary collaborations with the more-than human. What if we shifted teaching and learning to facilitate new ways of being on the planet, so that we prioritised ourselves, one another as well as non-human and more-than-humans in our educational ecologies. Building the digital literacies and computational thinking capabilities (George-Reyes, et al, 2021) to learn with GAI will create opportunities to thinking about the world and all its space and places, as interconnected and entangled.
In this trendsetter webinar I pose a series of questions and prompts that I had in conversation with Chatty G (ChatGPT) to consider how we might imagine and understand the world in different ways so that we might integrate generative AI and into our education ecologies in higher education.
Presentation: https://doi.org/10.26188/22281685
Ethik des Anthropozäns - Überlegungen zur dritten Natur
Authors: Noller Jörg 
Published: August 2023

Im Anthropozän tritt der Mensch als Naturmacht in Erscheinung, die sich in letzter Konsequenz auch gegen sich selbst wendet: Erste und zweite Natur verschmelzen zur dritten Natur. Doch welche Ethik ist dieser dritten Natur angemessen? Ausgehend von Immanuel Kant argumentiert dieser Essay dafür, ein kritisches Naturverhältnis zu entwickeln, welches sich immer auch als ein Selbstverhältnis manifestiert. Die Natur wird dabei weder personalisiert noch objektiviert. Vielmehr wird die Wechselwirkung zwischen Mensch und Natur in ihrer unauflöslichen Einheit als dritte Natur ernst genommen und auch ästhetisch weiter verständlich gemacht.
The use of pediatric behavior management techniques among Syrian dentists - A cross-sectional study
Authors: Alsibai Ekram , Karkoutly Mawia , Samra Elian Gattas Abu , Almonakel MHD Bashier , Bshara Nada 
Published: August 2023

Objectives:
The aim of this study was to evaluate and compare the attitude toward several behavior management techniques among Syrian pediatric dentists (PDs), general dental practitioners (GDPs), and other dental specialists (ODSs). Dental fear and anxiety are highly prevalent among schoolchildren and pre-school children. Behavior management techniques can be either pharmacological or non-pharmacological. Distraction is a non-pharmacological behavior management technique, which is safe, economical, and effective.

Materials and Methods:
A self-designed questionnaire was distributed through social networks. Syrian GDPs, PDs, and ODSs participated in the online questionnaire. The questionnaire consisted of four sections and required responses regarding participants’ demographic characteristics, work setting, the use of several behavior management techniques, and attitude toward tablet distraction use. Pearson’s Chi-square test was performed at 5% for statistical analysis using SPSS version 23.0.

Result:
A total of 642 participants responded. Most of the participants reported using tell-show-do (63.08%) and positive reinforcement (65.58%) techniques. Less than half of the participants (45.79%) used virtual reality (VR) eyeglasses for distraction. PDs used cartoons and storytelling techniques significantly more than GDPs and ODSs, with P = 0.023 and P < 0.001, respectively. However, most of the participants never used touch screen video games (74.45%) or joystick video games (92.21%) for distraction. Half of the questionnaire participants (52.34%) were unsure about using a tablet device for distraction.

Conclusion:
This study concluded that tell-show-do, positive reinforcement techniques, and VR eyeglasses were used the most. However, the vast majority of the participants never used video games for distraction. A good proportion of the study participants were hesitant about using a tablet device as a means of distraction.
LEGISLATION IN THE FIELD OF MEDICAL ACTIVITY: STATE AND APPROACHES TO ITS FORMATION AS A SYSTEM
Authors: Рузанова В.Д. , Крюкова Е.С. 
Published: August 2023

Объектом исследования являются общественные отношения, возникающие при осуществлении медицинской деятельности. Целью работы выступает комплексный анализ состояния законодательства в медицинской сфере. Основной задачей исследования является разработка рекомендаций по построению законодательства в сфере медицинской деятельности как системного объекта. Методологическую базу исследования составили как общенаучные, так и частнонаучные методы познания: описательный, лингвистический, сравнительно-правовой и др. В результатах исследования отмечается, что количественный рост нормативной составляющей в этом сегменте не сопровождается одновременным повышением уровня ее системности, что выражается, например, в слабой координации между Законом об охране здоровья и специальными законами, несогласованности положений специальных законов между собой и с подзаконной нормативной базой. В качестве вывода, в противовес предложенной в литературе идеи создания медицинского кодекса, обосновывается мысль о построении указанного законодательства на основе модели головного (базового, центрального) закона и предлагается структура последнего.
The object of the research is the social relations that arise in the course of medical activity. The aim of the work is a comprehensive analysis of the state of legislation in the field of the medical field. The main objective of the study is to develop recommendations for the construction of legislation in the field of medical activity as a system object. The methodological base of the study was made up of both general scientific and specific scientific methods of cognition: descriptive, linguistic, comparative legal, etc. The results of the study indicate that the quantitative growth of the normative component in this segment is not accompanied by a simultaneous increase in the level of its systematic character, which is expressed, for example, in weak coordination between the Law on Health Protection and special laws, inconsistency between the provisions of special laws among themselves, and with the subordinate regulatory framework. As a conclusion, in contrast to the idea of creating a medical code proposed in the literature, the idea of building the specified legislation on the basis of the model of the main (basic, central) law is substantiated and the structure of the latter is proposed.
Impact of Technological Innovations on Bank Performance in Selected West African Countries (1997-2020)
Authors: Enoruwa Ogbeide Kenneth , Onwumere J U J , Ibunor Agama Evwienure , Ehigie Humphrey Aimienrovbiye , Ezuem Daniel Moyotole 
Published: August 2023

Purpose: Technological innovations are understood as new or improved processes, products or services, the technical characteristics of which are significantly different from the previous ones. Technological innovations in the banking sector have undoubtedly improved the functionality and performance of banks across the globe including West African countries such as Nigeria, Ghana and Coted’Ivoire. It has redefined the way and regime in banking operation in West Africa. It enables banks to improve the quality of service delivery to their numerous customers and makes it easy for customers to access banking services at the lowest cost possible. This study, therefore, focused on examining the impact of technological innovations on bank performance in West Africa.

Method: A set of annual time series covering the period 1997 to 2020 and a multiple regression analysis including an autoregressive distributed lag (ARDL) model, a fully modified OLS (FMOLS) model and a dynamic OLS (DOLS) model were used. Bank performance was measured using bank return on assets (ROA) and bank return on equity (ROE), while technological innovation was measured using indicators such as Internet Banking (INB), Automated Teller Machines (ATM), Mobile Banking (MBN) and Point of Sale (POS) whose control variables are inflation rate (INFR) and exchange rate (EXR).

Results and conclusion: Findings from the ARDL panel results show that both positive and negative long-term relationships exist between technological innovation and bank performance in West Africa. We thoroughly verified the results from the ARDL model with FMOLS and DOLS and the findings show that technological innovation has a positive and negative long-run relationship with bank performance in West Africa and the results were the same for Nigeria, Ghana and Ivory Coast.

Originality/Value: This study, therefore, recommends that improving the quality of technologically innovative tools of banks such as internet banking, ATMs, POS and mobile banking with quality apparatus can lead to improved bank performance. Banks should also invest in cyber security to ensure funds deposited in banks are safe which will boost investor and customer confidence, acceptance and lead to increased bank performance.
Factors that Influence the Mechanism of Panic Buying: The Moderating Role of Personal Cognition
Authors: Lianjie Chen , Ahmad Albattat , Kassim Aza Azlina Md 
Published: August 2023

Purpose: The main aim of this research is to analyse the factors that contribute to panic buying behaviour and to give recommendations on government control tactics that might be used in similar situations.

Theoretical framework: Scarcity is the theoretical basis of current research in the context of COVID-19 in Quanzhou, Fujian Province, China. Collect and review previous relevant studies by theme to understand the latest literature trends of scarcity,
anxiety and panic buying.

Method: This research takes 213 clients from Quanzhou City in Fujian Province, China. Using SPSS 27 for regression analysis and PROCESS 3.4.1 for testing the moderating effect and to investigate the status of panic buying.

Findings: The problem of panic buying during public crisis circumstances, such as the COVID-19, was explored and solved in this study, it was discovered that: (1) group factors and anxiety have a significant positive impact on panic buying; (2) scarcity and government control have no significant impact on panic buying; and (3) there is no significant moderating effect of personal cognition between the two.

Research, practical & social implications: Research has found that scarcity has a significant positive correlation with panic buying and anxiety; Scarcity has a significant impact on panic buying through the mediating effect of individual anxiety. Personal cognition has a significant moderating effect on scarcity on panic buying and anxiety on panic buying.

Originality: The research problem addressed in this study is the phenomenon of panic
buying during public crisis events such as the COVID-19 pandemic. this study proposes ideas for guiding government control in public crisis events.
PEMETAAN DAERAH PENANGKAPAN IKAN BAWAL PUTIH (Pampus argenteus) DI PERAIRAN PANGANDARAN
Authors: Nurholisah Siti , Khan Alexander M.A. , Dewanti Lantun Paradhita , Syamsuddin Mega Laksmini 
Published: August 2023

Salah satu wilayah yang mempunyai potensi sumberdaya hayati laut yang cukup besar adalah Perairan Pangandaran. Ikan bawal putih (Pampus argenteus) merupakan salah satu sumberdaya hayati laut yang mempunyai nilai ekonomis yang tinggi. Pemetaan daerah penangkapan ikan bawal putih dapat dilakukan dengan pemanfaatan teknologi SIG. penelitian ini bertujuan untuk memetakan daerah penangkapan ikan bawal putih dan juga menganalisis hubungan parameter oseanografi dengan produktivitas tangkapannya. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Data yang digunakan diambil dari Aqua modis, ECMWF, DEMNAS, dan data dari Dinas Perikanan dan Ketahanan Pangan Kabupaten Pangandaran. Hasil penelitian menunjukan bahwa nilai CPUE tertinggi berada pada posisi 108˚47’49” BT dan 7˚45’59” LS dan nilai CPUE terendah berada pada posisi 108˚40’31” BT dan 7˚46’31” LS, suhu optimum berada pada kisaran 27-28˚C, klorofil-a optimum berada pada kisaran 3,1-4,0 mg/m3, nilai optimum arus berada pada kisaran 2,6-5,0 m/s dan nilai optimum kedalaman berada pada kisaran 16-36 m.
Kata kunci: bawal putih, pangandaran, pemetaan, SIG