bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Interpretable Deep Learning Optimized Wearable Daily Monitoring System for Parkinson's Disease Patients
Authors: Su Fei , Chen Min , Sun Zhanfang , Xin Tao , Bu Degang , Chen Yan 
Published: January 2023

Abstract
Walking monitoring in the daily life of patients with Parkinson's disease (PD) is of great significance for tracking the progress of the disease. This study aims to implement an accurate, objective, and long-term walking monitoring algorithm optimized by the interpretable deep learning architecture, and explore the most representative spatiotemporal motor features. Five inertial measurement units attached to the wrist, ankle, and waist are used to collect motion data from 100 subjects during a 10-meter walking test. The raw data of each sensor are subjected to the continuous wavelet transform before training in the constructed deep learning architecture based on a 6-channel convolutional neural network (CNN). The results show that the sensor located at the waist has the best classification performance with an accuracy of 98.01% ± 0.85% and the area under the receiver operating characteristic curve (AUC) of 0.9981 ± 0.0017 under ten-fold cross-validation. The gradient-weighted class activation mapping shows that the feature points with greater contribution to PD were concentrated in the lower frequency band (0.5~3Hz) compared with healthy controls. The visual maps of 3D CNN show that only three out of six time series have a greater contribution, which is used as a basis to further optimize the model input, and the raw data processing cost is reduced by 50% while the classification performance (AUC = 0.9929 ± 0.0019) is still maintained. As far as we know, this is the first study that considers visual interpretation-based optimization of an intelligent classification model in the objective diagnosis of PD.
Neural Epidermal Growth Factor–Like 1 Protein is a novel target antigen in membranous lupus nephritis of Chinese patients
Authors: Rao Qingqing , Cheng Yuan , Yue Shuling , Song Haiying , Qi Dongli , Chen Jia , Guan Mijie , Cao Tao , Zhe Wei , Wan Qijun , Li Wangyang 
Published: January 2023

Abstract
Neural Epidermal Growth Factor–Like 1（NELL-1）Protein may be the second most common target antigen of membranous nephropathy after PLA2R and more likely expressed in patients with secondary membranous nephropathy（sMN) . However, there are no relevant studies on the clinical characteristics of NELL-1 positive sMN in Chinese individuals,which is the focus of this study.A total of 100 patients with sMN were enrolled in our study.Immunofluorescence staining for PLA2R, THSD7A and NELL-1 were performed in their renal tissue samples. There are 13 cases of PLA2R-MN, 5 cases of NELL-1 association MN, and 82 cases of triple antigen-negative MN.The median age of NELL-1 associated sMN was 41 years, 80% are women,median urine protein 5.73 g/24 h ,median eGFR 42 mL/min/1.73 m2.It is noteworthy that all NELL-1 positive sMN patients in our cohort had a history of systemic lupus erythematosus(SLE), which accounted for 8.9% of SLE patient.there are four of five NELL-1 associated sMN patients pathologically manifested as IV/V lupus nephritis,and two patients entered ESRD within 1 year. So we supposed that NELL-1 related MN may be a special subgroup of membranous lupus nephritis(LMN) which may have a poor renal prognosis.
Study on pulp metabolism in patients with pulpitis via ultra-performance liquid chromatography coupled with Orbitrap mass spectrometry
Authors: Guo Ke , Xu Xiaodong , Gao Jianfang , Zhang Ying , Wang Yu , Zhu Yonggan , Zhou Zhenfeng , Chen Xuzhuo , Zhang Zhongxiao , Wei Wenjia 
Published: January 2023

Abstract
Background
Pulpitis, a pulp disease caused by several factors, including caries and trauma, has a high clinical incidence. In this study, our aim was to identify possible metabolic biomarkers in individuals with pulpitis and analyze the associated metabolic pathways to the end of providing a theoretical basis for pulpitis diagnosis and prevention.
Methods
Pulp samples from 12 individuals (six patients with pulpitis and six individuals with normal teeth) were analyzed via serum metabolomics based on ultra-high-performance liquid chromatography (UPLC)/Orbitrap mass spectrometry. Thereafter, to identify important biomarkers, we performed multivariate analysis and also established an orthogonal partial least squares discrimination analysis model. Further, we performed correlation analysis as well as biomarker pathway enrichment analysis to determine the associations between the differentially expressed biomarkers as well as their association with different biological pathways.
Results
22 biomarkers (13 upregulated and nine downregulated) we found to be significantly associated with 18 metabolic pathways in pulpitis. Specifically, the major biomarkers included ascorbic acid, inosine, allopurinol riboside, and L-asparagine, and among these, ascorbic acid and inosine were most significantly downregulated and showed the strongest correlation with pulpitis. Additionally, aminoacyl-tRNA biosynthesis and retrograde endocannabinoid signaling showed positive correlation with pulpitis.
Conclusions
These identified pulpitis-associated biomarkers and metabolic pathways may serve as a theoretical basis for further clarifying the pathogenesis of pulpitis and can be applied in the development of preventive drugs.
Women and authorship in an international journal dedicated to cardiovascular diseases: analysis of the last decade
Authors: Dominguez-Rodriguez Alberto , Gonzalez Julia , Baez-Ferrer Nestor , Diaz Rocio , Avanzas Pablo , Dominguez-Gonzalez Virginia , Hernandez-Baldomero Idaira F , Davo-Jimenez Maria , Garcia-Baute Maria del Carmen , Hernandez-Vaquero Daniel 
Published: January 2023

Abstract
The Revista Española de Cardiología (REC) is an international journal dedicated to cardiovascular diseases. The present study analyzes the authorship gender differences of the studies published in the REC over the last decade. A cross-sectional study was made of the REC issues published between January 2011 and December 2020, with a gender-based analysis of the number of authors, the type and year of publication and preferential authorship (first author, corresponding author or last author). Female participation was calculated from the female/male ratio, with an analysis of the trend observed over the years. A total of 2859 articles were documented, and the total signing authors corresponded to 4275 women and 12,061 men. In 1035 articles a woman held at least one preferential authorship. In 699 articles a woman was the first author, while in 548 articles a woman was the corresponding author, and in 481 articles a woman was the last author. The number of articles in which a woman was the first author or the corresponding author was seen to increase (p = 0.008 and p = 0.002, respectively), while no significant changes were observed in relation to last authorship (p = 0.09). The percentage of articles in which at least one woman held at least one of the three preferential authorship positions tended to increase over time (p = 0.056). In conclusion, although the participation of female authors in the scientific production of the REC has increased during the last decade, authorship gender inequalities persist.
Sipping as a nutritional supplement in ambulatory palliative oncology care – A pilot study with non-invasive methods.
Authors: Ticha Alena , Hyspler Radomir , Molnarova Veronika , Priester Peter , Tomasova Adela , Filip Stanislav 
Published: January 2023

Abstract
Objective. The implementation of nutritional support is a basic need of patients in palliative oncological care. This pilot study optimized the use of sipping to improve the nutritional status of cancer patients in palliative care.
Method. The pilot study included 63 patients, aged 61.3 years on average (range: 32 – 82 years of age). The patients were assigned to either group A (no nutritional support n=39 patients) or group B (sipping as nutritional support n=24 patients). The latter consisted of one nutridrink (12g protein, 36.8g saccharide, 11.6g fat, and 300kcal) per day, for at least three weeks. The patients were evaluated through by non-invasive methods, i.e. body weight, waist and arm circumference, and triceps skinfold, all of which were measured during the patients’ visit to the clinic. The body fat and fat-free mass ratio were evaluated with a bioimpedance analysis. Voluntary muscle strength was determined using dynamometry. Quality of life was assessed through modified questionnaires.
Results. In contrast with group A, group B did not have a significant weight loss, i.e. A: 81.9±15.8 kg - 80.5±15.8 kg (p=0.028); B: 73.9±14.9 kg - 73±16 kg. BMI A: 29±5 kg/m2 - 28.5±5 kg/m2 (p=0.007); B: 25.3±4.7 kg/m2 - 25±4.9 kg/m2 (p=0.614). Waist circumference A: 93.5±15.1 cm – 92.5±14.8 cm (p=0.008); B: 80.1 ± 13.2 cm – 80.6 ± 12.3 cm (p=0.234). Triceps skinfold A: 12.3±7.2 mm - 11±6.7 mm (p=0.001); B: 8.2±6.1 mm - 7.9±5.7 mm (p=0.207). Fat free mass A: 54.8 ±11.5 kg -52.8 ±11.6 kg (p=0.018); B: 54.7±10.9 - 52.8±11.5 kg (p=0.207). Significantly lower dynamometer values were recorded in both groups A: 25.6±10.4 kg – 23.1±10.3 kg (p=0.010); B: 27.4±9.9 kg – 24.3±9.1 kg (p=0.009). In contrast to group B, the patients in group A showed slight variations in their health status, thus decreasing their scores into the significance limit (p= 0.072).
Conclusion. Our results suggest that providing nutritional support in the form of sipping (~12g proteins, 300 kcal) on a daily basis prevents the loss of active tissue mass in palliative oncology patients. Based on these results, we recommend the inclusion of this simple nutritional support to prevent malnutrition in cancer patients in palliative care.
WITHDRAWN: PLK1 is a prognostic marker that inhibits immune infiltration in lung adenocarcinoma through necroptosis
Authors: Zhang Pengcheng , Zhang Xinglong , Zhu Yongfu , Cui Yiyi , Xu Jing , Zhang Weiping 
Published: January 2023

Abstract
Background
Polo-like kinase 1 (PLK1) is essential for cell mitosis division and has been associated with necroptosis. Although PLK1 and necroptosis are implicated in a variety of cancers, their function in lung adenocarcinoma (LUAD) is still not fully understood.
METHODS
The differential expression of PLK1 in LUAD was investigated utilizing Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases, and its prognostic significance was determined using the Kaplan-Meier test. Potential signaling pathways and biological activities were investigated using functional analysis. The overall survival (OS) of LUAD patients at 1, 3, and 5 years was predicted using multivariate Cox regression and validated using independent datasets. PLK1 was studied for its connection to immunological infiltration. Finally, the PLK1 impact on proliferation and apoptosis of LUAD cells was detected by overexpression and silencing PLK1. PLK1 impact on LUAD cell proliferation was verified by Western blot and in a xenograft model.
Result
PLK1 overexpression in LUAD was associated with TNM pathological staging, and residual tumor/smoking. High PLK1 expression correlated with lower OS, DFS, and DFI. PLK1 was determined as a significant predictor of LUAD by multivariate Cox regression. Functional analyses indicated PLK1 function was related to cell mitosis, neurotransmitter transmission and drug metabolism. Immune infiltration analysis showed that PLK1 was upregulated in cold tumors and inversely correlated to T cells, B cells and CD8+ T cells. Cellular assays demonstrated that PLK1 was significantly overexpressed in A549 and NCI-H1299 cell lines. Silencing PLK1 reduced proliferation and significantly increased LUAD cell apoptosis. Western Blot showed that the expression of necroptosis-related pathway proteins RIPK3, RIPK1, and MLKL was significantly increased after silencing PLK1. Finally, silencing PLK1 decreased LUAD cell proliferation in the xenograft model.
Conclusion
PLK1 may be a prognostic biomarker and suppresses LUAD immune infiltration by inhibiting necroptosis to promote LUAD cell proliferation.
Controlling Transition Photonic Band with
Synthetic Moiré Sphere
Authors: Liu Hui , Liu Zhinan , Zhao Xueqian , Yao Jie , Zhang Chi , Xu Jinlong , Zhu Shining 
Published: January 2023

Abstract
In recent years, twisted bilayer graphene has become a hot topic and inspired the research upsurge of photonic moiré lattice. Here, we designed a photonic moiré superlattice with two synthetic twist angles and constructed a synthetic moiré sphere based on these two angles. Thus, we have more degrees of freedom to modulate the band structure flexibly. A new type of transition photonic bands (TPBs) can be produced in such a moiré superlattice. We investigate the influence of two twist angles on TPBs and find a series of magic angle pairs with optimal band compression of TPB. The interesting optical properties of TPBs are experimentally demonstrated, including pulse delay, nonlinear optical enhancement and pulse width compression. Our work introduces a new path to explore multi-twist angles moiré superlattices and reveals that the reported photonic moiré superlattice based on moiré spheres has broad application prospects including nonlinear optics processes and other light-matter interactions.
Therapeutic Efficacy of Pyronaridine-artesunate (Pyramax ® ) Against Uncomplicated Plasmodium Falciparum Infection at Hamusit Health Center, Northwest Ethiopia
Authors: Alebachew Mihreteab , Gelaye Woyneshet , Alemu Megbaru , Sime Heven , Hailegeorgies Henok , Gidey Bokretsion , Haile Mebrahtom , Assefa Gudissa , Bekele Worku , Belay Habtamu , Parr Jonathan B , Tasew Geremew , Mohammed Hussein , Assefa Ashenafi 
Published: January 2023

Abstract
Background
Malaria remains a major public health problem in the world. Early detection of cases and prompt treatment are the major malaria control strategies implemented in many endemic countries, including Ethiopia. Artemisinin-based combination therapy is currently recommended by the World Health Organization (WHO) for the management of uncomplicated P. falciparum and P. vivax malaria cases. However, resistance to antimalarial drugs is a major challenge to the emergence and rapid spread of drug-resistant Plasmodium strains. Pyronaridine-artesunate (Pyramax) is an artemisinin combination therapy that has shown good efficacy for uncomplicated malaria in large-scale clinical trials conducted in Asia and Africa. This study reports the first therapeutic efficacy profile of Pyronaridine-artesunate against uncomplicated P. falciparum in Ethiopia.
Methods
A single-arm, prospective study with a 42-day follow-up period was conducted from March to May 2021 at Hamusit health center, according to the WHO protocol. A total of 90 adult P. falciparum mono-infection malaria cases (age ≥ 18 years) consented and were enrolled in the study. A standard single-dose regimen of Pyronaridine-artesunate was administered daily for 3 days, and clinical and parasitological outcomes were assessed at 42 days follow-up. Thick and thin blood films were prepared from capillary blood and examined by microscopy. Hemoglobin was measured using HemoCue® and dried blood spots were collected on day 0 and on the day of failure.
Results
Out of 90 patients, 86 (95.6%) had completed the 42-day follow-up study period. The overall PCR-corrected cure rate (adequate clinical and parasitological response) was very high at 98.9% (95% CI: 92.2–99.8%) with no serious adverse events. The parasite clearance rate was high with fast resolution of clinical symptoms; 95.6% and 100% of the study participants cleared parasitemia and fever on day 3, respectively. The mean hemoglobin concentration was significantly increased (p < 0.001) on day 14 compared to that on day 0.
Conclusion
Pyronaridine-artesunate was highly efficacious and safe against uncomplicated P. falciparum in the study population.
Semantic Segmentation of Nasal Septum Based on Parameter-Free Attention U-Net
Authors: Shulin Cui , xing Wang , yifan Wang , weibo Song 
Published: January 2023

Abstract
Accurate segmentation of nasal septum plays a key role in assisting doctors in nasal surgery. However, this practice is still a great challenge due to the variety in the shapes of nasal septum of different people. This paper brought forward an effective parameter-free attention U-Net for accurate segmentation of nasal septum. This attention module is an energy function, which is used to identify the importance of each pixel and provide three-dimensional attention weight for feature map inference in the layer without any additional parameters. On this basis, a new loss function of poly-diceloss was introduced, which regarded the diceloss as a linear combination of polynomial functions and significantly improved the segmentation performance by introducing a super parameter. In this paper, a data set named “nasal septum” was constructed. Based on this data set, a comparison was made with the most advanced network and the experimental results showed that the indexes of SAMU-Net proposed in this paper were: \(TPR\) 98.47%, \(PPV\) 83.57%, \(JAC\) 82.37%, \(Dice\) 90.23%, respectively, using the least network parameters.
Analysis on the salt tolerance of Nitraria sibirica Pall. based on Pacbio full-length transcriptome sequencing
Authors: Zhang Panpan , Wu Zhiheng , Su Naer , Zhang Fengxiang , Yan Yongqing , Liu Wei 
Published: January 2023

Abstract
N. sibirica, as a typical halophyte, can not only effectively repair saline-alkali land, but also has high economic value. However, the analysis on its salt tolerance at combining the molecular and physiological levels was little studied. Hence, in this study, the salt tolerance of N. sibirica was analyzed based on Pacbio full-length transcriptome sequencing, and the salt tolerance in the physiological levels was verified by key genes. The results found that 89,017 full-length transcripts were obtained, of which 84,632 sequences were annotated. The 86,482 coding sequence (CDS) sequences were predicted. In total, 6561 differentially expressed genes (DEGs) were identified. DEGs were significantly enriched in “response to salt stress”, “sodium ion homeostasis”, “response to osmotic stress”, “reactive oxygen species metabolic process”, “defense response by cell wall thickening” and “signal transduction”, et al. A total of 69 key genes were screened, of which 33 were not reported on salt tolerance. The NsRabE1c gene with the highest expression was selected to verify salt tolerance. The results showed that the gene regulates plant growth to resist salt stress. Results in the present study deepen the understanding of salinity resistance in N. sibirica and provide resources for further breeding projects under such stress conditions.
Economic Efficiency of an Open-Source National Medical Lab Software in Canada
Authors: Peplinski Jack E. , Pearce Joshua M. 
Published: January 2023

AbstractAlthough the Canada federal government has invested over $2.6 billion developing health information technology (HIT), all 10 provinces still have their own separate HIT systems, which are non-interoperable, expensive, and inconsistent. After first reviewing how these systems operate, this paper analyzes the costs and savings of integrating the common billing, lab results, and diagnostic imaging (BLD) functions of these separate systems using free and open-source software and proposes a system for this, HermesAPI. Currently, 8 provincial governments representing over 95% of Canada’s population allow private companies to create their own electronic medical records (EMR) system and integrate with provincial BLD systems. This study found the cost to develop and maintain HermesAPI would be between CAD$610,000 to CAD$740,000, but would prevent CAD$120,000 per company per province in development costs for a total savings of $6.4 million. HermesAPI would lower barriers to entry for the HIT industry to increase competition, improve the quality of HIT products, and ultimately patient care. The proposed open-source approach of the HermesAPI is one option towards building a more interoperable, less expensive, and more consistent HIT system for Canada.
CircRNA-mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance via PSIP1/c-Myc Axis Nuclear Translocation and Partially through Increasing EGFR Expression
Authors: Tang Yongchang , Yuan Feng , Cao Mingbo , Li Yuxuan , Ren Yupeng , Yang Gaoyuan , Zhong Zhaozhong , He Zhiwei , Nan Lin , Deng Meihai , Yao Zhicheng 
Published: January 2023

Abstract
Background
Hepatocellular Carcinoma (HCC) is one of the major malignant tumors threatening human health. Lenvatinib resistance seriously restricts the efficacy of HCC, but the specific mechanism is not clear. Circular RNA (circRNA) plays an important role in the regulation of tumor drug resistance.
Methods
Key circRNA was screened by bioinformatics methods, and further identified by relevant validation experiments and HCC tissue samples. And, circRNA was evaluated as a diagnostic and prognostic marker for HCC progression at the clinical level. After then, through in vivo and in vitro experiments, the specific mechanism of the circRNA on the progression of HCC and lenvatinib resistance was explored at the molecular level.
Results
circRNA_0009792 (circRNA-mTOR) was highly expressed in HCC and is closely related to the prognosis of patients, which has good diagnostic value and clinical significance. In vivo and in vitro experiments showed that circRNA-mTOR could promote the progression of hepatocellular carcinoma and promote lenvatinib resistance by improving the stemness of HCC cells. Mechanismly, circRNA-mTOR could affect RNA-binding protein (PSIP1) nuclear translocation by specifically binding to it, and then which enhanced the stemness of HCC cells through PSIP1/c-Myc axis, hence promoting the progression of HCC and lenvatinib resistance. And furthermore, circRNA-mTOR at least partially induce lenvatinib resistance by increasing the expression of EGFR in HCC.
Conclusions
In conclusion, this study suggests that circRNA-mTOR can affect PSIP1/c-myc axis nuclear translocation, to make progress of HCC and the maintenance of steness of liver cancer cell to aggravate lenvatinib resistance, And partially increased EGFR over-expression to making chemo-resistance worse. CircRNA-mTOR has the potential to be a biomarker for the diagnosis and prognosis of HCC. This study provides a certain experimental basis for the targeted drug therapy of HCC, and puts forward new ideas, new insights and new methods in understanding the occurrence and development of HCC, and it is of great significance to seek new markers and targets for the diagnosis and treatment of HCC and reduce drug resistance.