bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
Authors: Báez-Suárez Aníbal , Padrón-Rodríguez Iraya , Castellano-Moreno Elizabeth , González-González Erica , Quintana-Montesdeoca María P. , Medina-Ramirez Raquel Irina 
Published: September 2023

Abstract
Background
Children with neurodevelopmental disorders have a very wide clinical variability. A common prevalent factor is problems with stool and sleep quality. Currently, there are multiple studies related to their evaluation, but not so much related to a specific intervention. The aim was to evaluate the effectiveness and safety of the application of non-invasive neuromodulation as a treatment in children with neurodevelopmental disorders to improve constipation and quality of sleep.

Methods
A total of 23 minors aged between 2 and 16 were included in this cross-sectional study. All participants were applied the microcurrent device for 60 min, 3 times per week for a total of 4 weeks. The technique was based on non-invasive neuromodulation using a surface-applied microcurrent electrostimulation device that administers an external, imperceptible, pulsed electrical stimulation. It is applied to the extremities, in a coordinated manner, using gloves and anklets connected with electrodes to a control console. Sleep latency and microarousals were evaluated through a sleep diary. To assess the evolution and type of defecation, the adapted and validated version in Spanish of the Bristol Stool Form Scale was used.

Results
No adverse events occurred during the study and no incidences were registered. Clinically relevant improvements were registered in defecation frequency and type as well as in sleep related parameters. An increase in the hours of sleep was registered, from 7,35 (0,83) to 9,09 (1,35), and sleep interruptions decreased from 3,83 (1,95) to 1,17 (1,11), (p < .001).

Conclusion
Microcurrents can be used as an effective and safe treatment to improve quality of sleep and constipation in children with neurodevelopmental disorders. More studies are needed in order to obtain statistically significant results.

Trial Registration
ClinicalTrials.gov ID: NCT05265702.

First registration
03/03/2022

Protocol
https://clinicaltrials.gov/ct2/show/NCT05265702?term=baez+suarez&draw=2&rank=4
Association of liver function with health-related physical fitness: a cross-sectional study
Authors: Ye Bo , Zhang Jing , Tan Zeyu , Chen Jiangang , Pan Xinliang , Zhou Yuan , Wang Wanwan , Liu Longlong , Zhu Wenfei , Sun Yuliang , Ning Ke , Xie Qian , Liu Ronghua 
Published: September 2023

Abstract
Background
In this study, by analyzing the correlation between various components of health-related physical fitness (HPF) and liver function indicators, the indicators of physical fitness that were highly correlated with liver function and could be monitored at home were screened to prevent more serious liver disease in the future, and to provide experimental basis for prescribing personalized exercise.

Methods
A total of 330 faculties (female = 198) of a university were recruited. The indicators of HPF and liver function were measured. Spearman correlation analysis, multivariate linear regression, and cross-lagged panel model was used to data statistics.

Results
In males, body fat (BF) was positively correlated with alanine aminotransferase (ALT); vital capacity and the vital capacity index were positively correlated with albumin; and vertical jump was positively correlated with globulin and negatively correlated with the albumin-globulin ratio (P < 0.05). However, there was no significant correlation among all indicators controlled confounding factors. In females, BF was negatively correlated with direct bilirubin; VO2max was positively correlated with indirect bilirubin; and vertical jump was positively correlated with the albumin-globulin ratio and significantly negatively correlated with globulin (P < 0.05). Controlled confounding factors, body fat percentage was positively correlated with globulin (β = 0.174) and negatively correlated with direct bilirubin (β = –0.431), and VO2max was positively correlated with indirect bilirubin (β = 0.238, P < 0.05). Cross-lagged panel analysis showed that BF percentage can negatively predict direct bilirubin levels with great significance (β = -0.055, P < 0.05).

Conclusions
HPF may play a crucial role in liver function screening, particularly for female faculty members. For males, BF, vertical jump, vital capacity and vital capacity index could be associated with liver function but are susceptible to complex factors such as age, smoking, diabetes, and hypertension. In females, BF percentage is an important predictor of abnormal liver function in addition to VO2max and vertical jump, which are not affected by complex factors.
Reading man flap in four dogs: a case series
Authors: Siegelmayer Desiree , Gradner Gabriele 
Published: September 2023

Abstract
Background
The reading man flap is a novel technique in human medicine for the closure of cutaneous circular defects. To the best of our knowledge, no recent clinical studies have described this procedure in small animals.

Case presentation
In this case series, we present four dogs in which neoplasms were reconstructed using the reading man procedure, which is a double-advancement transposition subdermal flap. The reading man flap was applied in wound revision after surgical removal of a neoplasm in two dogs and in the closure following the excision of a neoplasm in another two dogs. Successful tension-free closure of the lesion site was achieved in all four patients. The postoperative period was uneventful in all patients, and there was no flap necrosis or surgical site infection, although surgical site infection preceded in two cases. Minor complications included partial suture dehiscence in one dog and seroma formation in two dogs. Only one dog required a second anesthesia to insert an active drainage system. The follow-up examination of all four dogs revealed no further complications with the reading man flap at time of the latest wound reevaluation conducted by the surgeon.

Conclusion
The reading man flap is a well-vascularized fasciocutaneous flap that provides tension-free closure owing to its asymmetrical Z-plasty. It is a simple-to-use option for the closure of circular skin lesions in dogs.
Divergent functions of NLRP3 inflammasomes in cancer: a review
Authors: Shadab Alireza , Mahjoor Mohamad , Abbasi-Kolli Mohammad , Afkhami Hamed , Moeinian Parisa , Safdarian Amir-Reza 
Published: September 2023

AbstractThe cancer is a serious health problem, which is The cancer death rate (cancer mortality) is 158.3 per 100,000 men and women per year (based on 2013–2017 deaths). Both clinical and translational studies have demonstrated that chronic inflammation is associated with Cancer progression. However, the precise mechanisms of inflammasome, and the pathways that mediate this phenomenon are not fully characterized. One of the most recently identified signaling pathways, whose activation seems to affect many metabolic disorders, is the “inflammasome” a multiprotein complex composed of NLRP3 (nucleotide-binding domain and leucine-rich repeat protein 3), ASC (apoptosis associated speck-like protein containing a CARD), and procaspase-1. NLRP3 inflammasome activation leads to the processing and secretion of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18. The goal of this paper is to review new insights on the effects of the NLRP3 inflammasome activation in the complex mechanisms of crosstalk between different organs, for a better understanding of the role of chronic inflammation in cancer pathogenesis. We will provide here a perspective on the current research on NLRP3 inflammasome, which may represent an innovative therapeutic target to reverse the malignancy condition consequences of the inflammation.
Recombinase-independent AAV for anterograde transsynaptic tracing
Authors: Faress Islam , Khalil Valentina , Yamamoto Haruka , Sajgo Szilard , Yonehara Keisuke , Nabavi Sadegh 
Published: September 2023

AbstractViral transsynaptic labeling has become indispensable for investigating the functional connectivity of neural circuits in the mammalian brain. Adeno-associated virus serotype 1 (AAV1) allows for anterograde transneuronal labeling and manipulation of postsynaptic neurons. However, it is limited to delivering an AAV1 expressing a recombinase which relies on using transgenic animals or genetic access to postsynaptic neurons. We reasoned that a strong expression level could overcome this limitation. To this end, we used a self-complementary AAV of serotype 1 (scAAV1) under a strong promoter (CAG). We demonstrated the anterograde transneuronal efficiency of scAAV1 by delivering a fluorescent marker in mouse retina-superior colliculus and thalamic-amygdala pathways in a recombinase-independent manner in the mouse brain. In addition to investigating neuronal connectivity, anterograde transsynaptic AAVs with a strong promoter may be suitable for functional mapping and imaging.
The effect of abdominal bracing on respiration during a lifting task: a cross-sectional study
Authors: Sembera Martin , Busch Andrew , Kobesova Alena , Hanychova Barbora , Sulc Jan , Kolar Pavel 
Published: September 2023

Abstract
Background
Abdominal bracing is a maneuver widely used by rehabilitation specialists and sports trainers to improve spinal stability. This study aimed to investigate how lifting tasks with and without abdominal bracing affect the respiratory function of the diaphragm.

Methods
M-mode ultrasonographic assessment of diaphragmatic motion combined with spirometry was performed on 31 healthy adults. Participants were asked to breathe continuously whilst lifting a load with spontaneous abdominal muscle contraction (natural loaded breathing) and abdominal bracing (AB loaded breathing).

Results
Pearson’s correlations revealed strong correlations between ultrasonography and spirometry measures (p < 0.001) for all types of breathing: tidal breathing (r = 0.709, r2 = 0.503), natural loaded breathing (r = 0.731, r2 = 0.534) and AB loaded breathing (r = 0.795, r2 = 0.632). Using paired-samples t-tests, the natural loaded breathing ultrasonography revealed more caudal diaphragm positions during inspiration (p < 0.001) but not during expiration (p = .101). Spirometry demonstrated lower lung volumes (L) at the end of inspiration and expiration (p < 0.001), with no changes in total lung volume (p = 0.06). The AB loaded breathing ultrasonography revealed more caudal diaphragm positions during inspiration (p = 0.002) but not during expiration (p = 0.05). Spirometry demonstrated lower lung volumes at the end of inspiration (p < 0.001), expiration (p = 0.002), and total lung volumes (p = 0.019).

Conclusion
This study demonstrated that abdominal bracing performed during a lifting task reduces lung volume despite an increase in diaphragmatic motion. Diaphragm excursions strongly correlate with lung volumes even under postural loading.

Trial registration
The study was prospectively registered on 8 April 2021 at ClinicalTrials.gov with identification number NCT04841109.
Prognosis and management of acute symptomatic seizures: a prospective, multicenter, observational study
Authors: Herzig-Nichtweiß Julia , Salih Farid , Berning Sascha , Malter Michael P. , Pelz Johann O. , Lochner Piergiorgio , Wittstock Matthias , Günther Albrecht , Alonso Angelika , Fuhrer Hannah , Schönenberger Silvia , Petersen Martina , Kohle Felix , Müller Annekatrin , Gawlitza Alexander , Gubarev Waldemar , Holtkamp Martin , Vorderwülbecke Bernd J. ,   IGNITE! study group
Published: September 2023

Abstract
Background
Acute symptomatic epileptic seizures are frequently seen in neurocritical care. To prevent subsequent unprovoked seizures, long-term treatments with antiseizure medications are often initiated although supporting evidence is lacking. This study aimed at prospectively assessing the risk of unprovoked seizure relapse with respect to the use of antiseizure medications. It was hypothesized that after a first acute symptomatic seizure of structural etiology, the cumulative 12-month risk of unprovoked seizure relapse is ≤ 25%.

Methods
Inclusion criteria were age ≥ 18 and acute symptomatic first-ever epileptic seizure; patients with status epilepticus were excluded. Using telephone and mail interviews, participants were followed for 12 months after the acute symptomatic first seizure. Primary endpoint was the occurrence and timing of a first unprovoked seizure relapse. In addition, neuro-intensivists in Germany were interviewed about their antiseizure treatment strategies through an anonymous online survey.

Results
Eleven of 122 participants with structural etiology had an unprovoked seizure relapse, resulting in a cumulative 12-month risk of 10.7% (95%CI, 4.7%–16.7%). None of 19 participants with a non-structural etiology had a subsequent unprovoked seizure. Compared to structural etiology alone, combined infectious and structural etiology was independently associated with unprovoked seizure relapse (OR 11.1; 95%CI, 1.8–69.7). Median duration of antiseizure treatment was 3.4 months (IQR 0–9.3). Seven out of 11 participants had their unprovoked seizure relapse while taking antiseizure medication; longer treatment durations were not associated with decreased risk of unprovoked seizure relapse. Following the non-representative online survey, most neuro-intensivists consider 3 months or less of antiseizure medication to be adequate.

Conclusions
Even in case of structural etiology, acute symptomatic seizures bear a low risk of subsequent unprovoked seizures. There is still no evidence favoring long-term treatments with antiseizure medications. Hence, individual constellations with an increased risk of unprovoked seizure relapse should be identified, such as central nervous system infections causing structural brain damage. However, in the absence of high-risk features, antiseizure medications should be discontinued early to avoid overtreatment.
Existence and Hyers–Ulam stability of stochastic integrodifferential equations with a random impulse
Authors: Kasinathan Ramkumar , Kasinathan Ravikumar , Sandrasekaran Varshini , Baleanu Dumitru 
Published: September 2023

AbstractThe theoretical approach of random impulsive stochastic integrodifferential equations (RISIDEs) with finite delay, noncompact semigroups, and resolvent operators in Hilbert space is investigated in this article. Initially, a random impulsive stochastic integrodifferential system is proposed and the existence of a mild solution for the system is established using the Mönch fixed-point theorem and contemplating Hausdorff measures of noncompactness. Then, the stability results including a continuous dependence of solutions on initial conditions, exponential stability, and Hyers–Ulam stability for the aforementioned system are investigated. Finally, an example is proposed to validate the obtained results.
Association of gender-related factors and household food security in southwest Oromia, Ethiopia: evidence from a cross-sectional study
Authors: Hiruy Honelgn Nahusenay , Barden-O’Fallon Janine , Mitiku Fikadu , Millar Elizabeth 
Published: September 2023

Abstract
Background
Food insecurity is a major concern across Ethiopia and a long-standing public health problem. Vulnerability to food insecurity varies by several individual and household factors; however, understanding the role of gender-related factors can serve as additional input for designing policy and interventions. A cross-sectional survey was conducted in the Yayu Coffee Forest Biosphere Reserve in southwest Oromia, Ethiopia as part of a baseline assessment for the My Forest, My Livelihood, My Family program. A total of 1.113 households were selected from six woredas (districts) using a two-stage sampling procedure. The outcome variable was measured using the Household Food Insecurity Access Scale, version 3. The association between gender-related factors and household food security was assessed by fitting a logistic regression.

Results
The prevalence of food insecurity was 62.4%, with 28.1% of households assessed as severely food insecure. Households with both the wife and husband making decisions about major purchases were associated with an increased odds of household food security (adjusted odds ratio [AOR] 1.44, confidence interval [CI] 1.06, 1.96). The odds increased when the woman alone made these decisions (AOR 2.15, CI 1.20, 3.85). Women’s formal education was also associated with increased odds of household food security.

Conclusions
This study adds evidence that policy and programmatic interventions that improve the agency of women to participate in asset ownership and household economic decision making, expand female literacy and education, and diversify income sources to include off-farm wage employment in the Yayu Coffee Forest Biosphere Reserve are important steps for improving household food security.
Correlation of skeletal age by Greulich-Pyle atlas, physiological age by body development index, and dental age by London Atlas and modified Demirjian’s technique in children and adolescents of an Eastern Indian population
Authors: Behera Champak Kumar , Rath Rachna , Das Surya Narayan , Sahu Geeta , Sharma Gaurav , Bhatta Archana 
Published: September 2023

Abstract
Background
Forensic age estimation using multiple maturity indicators necessitates investigation of correlation between various techniques. This study intended to compare and evaluate the correlation between skeletal age using Greulich-Pyle atlas, dental age by Acharya’s modification of Demirjian’s technique and London Atlas method of Tooth Development, and age estimated by body developmental index with chronological age. Orthopantomograms and left hand-wrist radiographs of one hundred seventy-four subjects (64 males and 70 females) in the age group of 8–20 years were evaluated by age estimation methods. Physical parameters including height, weight, biacromial breadth, and biliospinale breadth were measured. The data were entered in the SPSS software (Version 27.0). Comparison between age estimation methods was done using Student’s t-test for paired samples. Unpaired t-test was utilized for gender-wise comparison of age. Pearson’s correlation coefficient was calculated to assess correlation between the various methods.

Results
Significant mean differences were noted between the chronological age and all the age estimation methods when Greulich-Pyle atlas method (− 0.43), modified Demirjian’s method (− 0.31), London Atlas Method (− 0.62), and body developmental index (− 0.51) were employed respectively. Inter-group comparison between all methods yielded no significant differences except for modified Demirjian’s method and London Atlas method (mean difference = 0.31). All the age estimation techniques showed strong correlation with chronological age; the best was provided by the Greulich-Pyle method (r = 0.92).

Conclusion
All the assessed age estimation techniques show strong correlation with chronological age. Acharya’s modified Demirjian’s method (dental age) and Greulich-Pyle atlas method (skeletal age) showed good accuracy and strong correlation with chronological age, suggesting that these methods can be used simultaneously and/or interchangeably for age assessment in children and adolescents of Eastern Indian population.
Capital structure and financial sustainability: stakes of microfinance institutions in Bamenda, Cameroon
Authors: Fonchamnyo Dobdinga Cletus , Anyangwe Tony , Chantal Ndichia Nana , Dinga Gildas Dohba 
Published: September 2023

AbstractThis research assesses the effect of capital structure on the sustainability of Microfinance Institutions (MFIs) in Bamenda, Cameroon. We use panel data obtained from audited annual financial statements of fifteen (15) MFIs, comprising both member- and shareholder-owned MFIs in Bamenda, Cameroon from 2014 to 2020, and an ex-post facto causal research design. Debt, equity, grants, and retained earnings are used to capture capital structure, while Operational Self-Sufficiency is used as a proxy for sustainability. The Generalised Least Squares and the quantile-on-quantile techniques are used for data analysis. Our findings indicate a statistically significant negative relationship between debt, grants and financial sustainability of MFIs, while a statistically significant positive relationship is found between retained earnings and financial sustainability of MFIs. A positive, though statistically insignificant relationship is found between equity or share capital and MFI financial sustainability. The results are robust upon consideration of different quantiles. Based on the findings, MFIs in Cameroon should rely more on retained earnings and equity to be more financially sustainable. The findings additionally provide evidence relating to the shortcoming of grants in the financing of development initiatives.
Deep sedation for nasal septal surgery: an observational retrospective study with an inverse probability weighting model
Authors: Campiglia Laura , Consales Guglielmo , Zamidei Lucia , Garotta Matteo , Sarno Antonio , Cappellini Iacopo 
Published: September 2023

Abstract
Background
Septoplasty, a common surgical procedure to correct a deviated septum, can be performed under either general anesthesia or deep sedation anesthesia. The choice of anesthesia can influence the duration of anesthesia and surgical outcomes, impacting the feasibility of outpatient procedures.

Methods
The institutional review board approved the protocol, and we obtained written informed consent from all participants. This retrospective, single-center observational study analyzed data from 586 patients who underwent rhino septoplasty at Santo Stefano Hospital in Prato, Italy, from 2017 to 2021. Patients received either general anesthesia or deep sedation anesthesia. Propensity score matching and inverse probability weighting were used to balance patient characteristics. The main outcome variable was discharge time, with anesthesia time and surgical time as covariates. Statistical analysis was conducted using R software.

Results
Patients who received deep sedation anesthesia had a significantly shorter duration of anesthesia compared to those who received general anesthesia. A multivariate linear regression model showed that the type of anesthesia had a strong positive association with discharge time, while anesthesia time had a weaker negative association, although not statistically significant.

Conclusions
Deep sedation anesthesia is associated with a shorter duration of anesthesia compared to general anesthesia during nasal septal surgery, suggesting it could be a more feasible option for outpatient procedures. However, the choice of anesthesia should be tailored to individual patient factors and surgical requirements. Further research is needed to confirm these findings and explore the potential benefits of sedation anesthesia in outpatient nasal septal surgery.

Question
How do general anesthesia and deep sedation anesthesia compare in terms of duration of anesthesia and surgical outcomes during nasal septal surgery?

Findings
Our study found that deep sedation anesthesia was associated with a shorter duration of anesthesia compared to general anesthesia in patients undergoing nasal septal surgery. However, there were no significant differences in the duration of the surgical procedure.

Meaning
The findings suggest that deep sedation anesthesia could potentially make nasal septal surgery more feasible as an outpatient procedure.