bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis
Authors: Tukacs Vanda , Mittli Dániel , Hunyadi-Gulyás Éva , Hlatky Dávid , Medzihradszky Katalin F. , Darula Zsuzsanna , Nyitrai Gabriella , Czurkó András , Juhász Gábor , Kardos József , Kékesi Katalin A. 
Published: February 2023

Abstract

Declining cerebral blood flow leads to chronic cerebral hypoperfusion which can induce neurodegenerative disorders, such as vascular dementia. The reduced energy supply of the brain impairs mitochondrial functions that could trigger further damaging cellular processes. We carried out stepwise bilateral common carotid occlusions on rats and investigated long-term mitochondrial, mitochondria-associated membrane (MAM), and cerebrospinal fluid (CSF) proteome changes. Samples were studied by gel-based and mass spectrometry-based proteomic analyses. We found 19, 35, and 12 significantly altered proteins in the mitochondria, MAM, and CSF, respectively. Most of the changed proteins were involved in protein turnover and import in all three sample types. We confirmed decreased levels of proteins involved in protein folding and amino acid catabolism, such as P4hb and Hibadh in the mitochondria by western blot. We detected reduced levels of several components of protein synthesis and degradation in the CSF as well as in the subcellular fractions, implying that hypoperfusion-induced altered protein turnover of brain tissue can be detected in the CSF by proteomic analysis.
Challenge and threat appraisal of entrepreneurial errors: a latent profile analysis and examination of coping responses
Authors: Kleine Anne-Kathrin , Schmitt Antje , Wisse Barbara M. 
Published: February 2023

AbstractAccording to transactional stress theory (TST), the extent to which entrepreneurs cope with errors by engaging in error damage control or ruminating about disengaging from their business goals depends on whether they interpret action errors as predominantly challenging or threatening. Using latent profile analysis (LPA), the current study investigates the existence of latent profiles of challenge and threat appraisal of entrepreneurial errors and their relationship with error damage control and rumination about business goal disengagement in a sample of 649 entrepreneurs. The results identify five appraisal profiles characterized by different challenge and threat appraisal intensities. The levels of error damage control and rumination about business goal disengagement differed between the profiles. Specifically, entrepreneurs high in challenge and threat appraisal showed higher levels of both forms of coping than those low in appraisal. Entrepreneurs falling into a high challenge and low threat appraisal profile exhibited the lowest level of business goal disengagement. Still, they showed similar levels of error damage control to those high on challenge and threat appraisal. Implications for the further development of TST and the development of effective error management interventions are discussed.
Genom-Editierung ohne die DNA-Sequenz zu verändern — geht das?
Authors: Schönberg Pascal Y. , Ding Li , Buchholz Frank 
Published: February 2023

AbstractEpigenetic genome engineering expands our capabilities from modifying the DNA sequence to controlling its regulation. It provides the ability to change epigenetic marks at defined genomic loci to control gene expression without the need for an intervention in the genetic code. This short review touches on current approaches of epigenetic editing with a focus on long-term gene silencing.
Nicht-codierende RNA als Regulator der Neurogenese
Authors: Schneider Marius , Becker Peter B. 
Published: February 2023

AbstractLong, non-coding (Inc) RNAs emerge as crucial regulators of gene expression. Their ability to interact with DNA and protein mediates the recruitment of regulators to defined chromosomal loci. LncRNAs are particularly abundant in brain tissues where they are involved in cell specification. We described a novel lncRNA, RUS (RNA upstream to Slitrk3), which interacts with epigenetic regulators and contributes to shaping the gene expression program of neural precursor cells towards neurogenesis.
Vitamin A ist unerlässlich für die Funktion unserer Blutstammzellen
Authors: Rettkowski Jasmin , Mess Julian , Cabezas-Wallscheid Nina 
Published: February 2023

AbstractHematopoietic stem cells (HSCs) hold the unique capacity to restore the entire blood system throughout life. To preserve life-long stem cell functionality, metabolic, epigenetic and transcriptional drivers form complex regulatory networks to tightly regulate HSCs. This interplay can be controlled by single metabolites, especially vitamins, instructing those epigenetic and transcriptional attributes. A non-classical retinoic acid (RA) signaling axis has been shown to be indispensable for protection of stem cell features in HSCs.
Exploring children’s negotiation of meanings about “D” in 2D and 3D shapes in a year 5/6 New Zealand primary classroom
Authors: Sharma Shweta 
Published: February 2023

AbstractThe mathematical construct of dimension is one of the fundamental ideas for developing a sound understanding of two-dimensional (2D) and three-dimensional (3D) shapes. Yet, research in mathematics education has rarely explored children’s understanding of dimension in primary education. This paper explores how year 5/6 (9 to 11 years old) children construct and negotiate their meanings about dimension while engaging in classroom interactions about 2D and 3D shapes during geometry lessons in a New Zealand (NZ) English-medium multilingual primary classroom. Transcribed data of two key moments selected from six audiovisually recorded geometry lessons are presented. The findings suggest that children may use different discursive constructions—“another world”, “different ways to go”, and “flat vs fat”—to display their meanings about dimension. The findings also suggest that children and teacher participants may use prosodic features of their languages to interactionally construct the meanings of these discursive constructions. The paper discusses these findings in light of current research literature and offers a few implications for curriculum development and future research.
Diffusion of Geographical Indication Law in Vietnam: “Journey To The West”
Authors: Nguyen Sy Luong , Le Van Anh 
Published: February 2023

AbstractFor a long time, Vietnamese legislators and scholars did not discuss geographical indication (GI) law in depth despite its having been long established in the country. However, when Vietnam signed the EU-Vietnam Free Trade Agreement (EVFTA) in 2020, the tide turned: GIs now have a “VIP seat” in the treaty text. Without debating whether GIs have boosted local agriculture, this article discovers how and why the law has been transposed into Vietnamese law. To this end, we first accept Watson and Twining’s theories to presuppose legal transplant. Then, we employ five models surveyed by Morin and Gold to appraise how lawmakers adopt rules that might not always benefit the adopting country. We conclude that the EVFTA is a key influencer in disseminating the relevant policy, but that enforcement is far from successful.
Cooperative multi-agent target searching: a deep reinforcement learning approach based on parallel hindsight experience replay
Authors: Zhou Yi , Liu Zhixiang , Shi Huaguang , Li Si , Ning Nianwen , Liu Fuqiang , Gao Xiaozhi 
Published: February 2023

AbstractMulti-agent multi-target search strategies can be utilized in complex scenarios such as post-disaster search and rescue by unmanned aerial vehicles. To solve the problem of fixed target and trajectory, the current multi-agent multi-target search strategies are mainly based on deep reinforcement learning (DRL). However, the training of agents by the DRL tend to be brittle due to their sensitivity to the training environment, which makes the strategies learned by the agents fall into local optima frequently, resulting in poor system robustness. Additionally, sparse rewards in DRL will lead to the problems such as difficulty in system convergence and low utilization efficiency of the sampled data. To address the problem that the robustness of the agents is weakened and the sparse rewards exist in the multi-objective search environment, we propose a MiniMax Multi-agent Deep Deterministic Policy Gradient based on the Parallel Hindsight Experience Replay (PHER-M3DDPG) algorithm, which adopts the framework of centralized training and decentralized execution in continuous action space. To enhance the system robustness, the PHER-M3DDPG algorithm employs a minimax learning architecture, which adaptively adjusts the learning strategy of agents by involving adversarial disturbances. In addition, to solve the sparse rewards problem, the PHER-M3DDPG algorithm adopts a parallel hindsight experience replay mechanism to increase the efficiency of data utilization by involving virtual learning targets and batch processing of the sampled data. Simulation results show that the PHER-M3DDPG algorithm outperforms the existing algorithms in terms of convergence speed and the task completion time in a multi-target search environment.
Ist eine analytische Geistesgeschichte möglich? Vier Thesen
Authors: Perler Dominik 
Published: February 2023

ZusammenfassungWie ist es möglich, philosophische Texte analytisch zu erschließen, gleichzeitig aber auch historisch zu kontextualisieren und dadurch analytische Geistesgeschichte zu betreiben? Der Text beantwortet diese Frage, indem er vier Thesen vorstellt. (1) Gemäß der Nominalismus-These müssen einzelne Texte, nicht etwa allgemeine Strömungen oder Ideen, in den Blick genommen werden. (2) Die Relationismus-These besagt, dass diese Texte stets zu anderen Texten in ihrem historischen Kontext in Beziehung zu setzen sind. (3) Die Multiperspektivismus-These betont, dass Texte in verschiedenen Kontexten zu berücksichtigen sind, sodass unterschiedliche Arten von Relationen deutlich werden. (4) Schließlich fordert die Historiographie-These, dass neben den Texten auch die Interpretationsschemata kritisch geprüft werden. Alle vier Thesen werden mit Bezug auf Texte der mittelalterlichen Philosophie erläutert.
A Review of Big Data in Road Freight Transport Modeling: Gaps and Potentials
Authors: Shoman Wasim , Yeh Sonia , Sprei Frances , Köhler Jonathan , Plötz Patrick , Todorov Yancho , Rantala Seppo , Speth Daniel 
Published: February 2023

AbstractRoad transport accounted for 20% of global total greenhouse gas emissions in 2020, of which 30% come from road freight transport (RFT). Modeling the modern challenges in RFT requires the integration of different freight modeling improvements in, e.g., traffic, demand, and energy modeling. Recent developments in 'Big Data' (i.e., vast quantities of structured and unstructured data) can provide useful information such as individual behaviors and activities in addition to aggregated patterns using conventional datasets. This paper summarizes the state of the art in analyzing Big Data sources concerning RFT by identifying key challenges and the current knowledge gaps. Various challenges, including organizational, privacy, technical expertise, and legal challenges, hinder the access and utilization of Big Data for RFT applications. We note that the environment for sharing data is still in its infancy. Improving access and use of Big Data will require political support to ensure all involved parties that their data will be safe and contribute positively toward a common goal, such as a more sustainable economy. We identify promising areas for future opportunities and research, including data collection and preparation, data analytics and utilization, and applications to support decision-making.
Anterior vertebral body tethering for adolescent idiopathic scoliosis associated with less early post-operative pain and shorter recovery compared with fusion
Authors: O’Donnell Jennifer M. , Gornitzky Alex L. , Wu Hao-Hua , Furie Kira S. , Diab Mohammad 
Published: February 2023

Abstract
Purpose
While posterior spinal instrumentation and fusion (PSIF) for severe adolescent idiopathic scoliosis (AIS) is the gold standard, anterior vertebral body tethering (AVBT) is becoming an alternative for select cases. Several studies have compared technical outcomes for these two procedures, but no studies have compared post-operative pain and recovery.

Methods
In this prospective cohort, we evaluated patients who underwent AVBT or PSIF for AIS for a period of 6 weeks after operation. Pre-operative curve data were obtained from the medical record. Post-operative pain and recovery were evaluated with pain scores, pain confidence scores, PROMIS scores for pain behavior, interference, and mobility, and functional milestones of opiate use, independence in activities of daily living (ADLs), and sleeping.

Results
The cohort included 9 patients who underwent AVBT and 22 who underwent PSIF, with a mean age of 13.7 years, 90% girls, and 77.4% white. The AVBT patients were younger (p = 0.03) and had fewer instrumented levels (p = 0.03). Results were significant for decreased pain scores at 2 and 6 weeks after operation (p = 0.004, and 0.030), decreased PROMIS pain behavior at all time points (p = 0.024, 0.049, and 0.001), decreased pain interference at 2 and 6 weeks post-operative (p = 0.012 and 0.009), increased PROMIS mobility scores at all time points (p = 0.036, 0.038, and 0.018), and faster time to functional milestones of weaning opiates, independence in ADLs, and sleep (p = 0.024, 0.049, and 0.001).

Conclusion
In this prospective cohort study, the early recovery period following AVBT for AIS is characterized by less pain, increased mobility, and faster recovery of functional milestones, compared with PSIF.

Level of evidence
IV.
Regulating lethal autonomous weapon systems: exploring the challenges of explainability and traceability
Authors: Christie Edward Hunter , Ertan Amy , Adomaitis Laurynas , Klaus Matthias 
Published: February 2023

AbstractWe explore existing political commitments by states regarding the development and use of lethal autonomous weapon systems. We carry out two background reviewing efforts, the first addressing ethical and legal framings and proposals from recent academic literature, the second addressing recent formal policy principles as endorsed by states, with a focus on the principles adopted by the United States Department of Defense and the North Atlantic Treaty Organization. We then develop two conceptual case studies. The first addresses the interrelated principles of explainability and traceability, leading to proposals for acceptable scope limitations to these principles. The second considers the topic of deception in warfare and how it may be viewed in the context of ethical principles for lethal autonomous weapon systems.
Contact Heat in Magnetoencephalography: A Systematic Review
Authors: Graeme-Drury Thomas J. , Worthen Siân F. , Maden Michelle , Raphael Jon H. , Khan Salim , Vreugdenhil Martin , Duarte Rui V. 
Published: February 2023

ABSTRACT:Background:Contact heat is commonly used in experimental research to evoke brain activity, most frequently acquired with electroencephalography (EEG). Although magnetoencephalography (MEG) improves spatial resolution, using some contact heat stimulators with MEG can present methodological challenges. This systematic review assesses studies that utilise contact heat in MEG, their findings and possible directions for further research.Methods:Eight electronic databases were searched for relevant studies, in addition to the selected papers' reference lists, citations and ConnectedPapers maps. Best practice recommendations for systematic reviews were followed. Papers met inclusion criteria if they used MEG to record brain activity in conjunction with contact heat, regardless of stimulator equipment or paradigm.Results:Of 646 search results, seven studies met the inclusion criteria. Studies demonstrated effective electromagnetic artefact removal from MEG data, the ability to elicit affective anticipation and differences in deep brain stimulation responders. We identify contact heat stimulus parameters that should be reported in publications to ensure comparisons between data outcomes are consistent.Conclusions:Contact heat is a viable alternative to laser or electrical stimulation in experimental research, and methods exist to successfully mitigate any electromagnetic noise generated by PATHWAY CHEPS equipment – though there is a dearth of literature exploring the post-stimulus time window.
AtmoDist: Self-supervised representation learning for atmospheric dynamics
Authors: Hoffmann Sebastian , Lessig Christian 
Published: February 2023

Abstract
Representation learning has proven to be a powerful methodology in a wide variety of machine-learning applications. For atmospheric dynamics, however, it has so far not been considered, arguably due to the lack of large-scale, labeled datasets that could be used for training. In this work, we show how to sidestep the difficulty and introduce a self-supervised learning task that is applicable to a wide variety of unlabeled atmospheric datasets. Specifically, we train a neural network on the simple yet intricate task of predicting the temporal distance between atmospheric fields from distinct but nearby times. We demonstrate that training with this task on the ERA5 reanalysis dataset leads to internal representations that capture intrinsic aspects of atmospheric dynamics. For example, when employed as a loss function in other machine-learning applications, the derived AtmoDist distance leads to improved results compared to the

$ {\mathrm{\ell}}_2 $

-loss. For downscaling one obtains higher resolution fields that match the true statistics more closely than previous approaches and for the interpolation of missing or occluded data the AtmoDist distance leads to results that contain more realistic fine-scale features. Since it is obtained from observational data, AtmoDist also provides a novel perspective on atmospheric predictability.
Tango Controls and data pipeline for petawatt laser experiments
Authors: Weiße Nils , Doyle Leonard , Gebhard Johannes , Balling Felix , Schweiger Florian , Haberstroh Florian , Geulig Laura D. , Lin Jinpu , Irshad Faran , Esslinger Jannik , Gerlach Sonja , Gilljohann Max , Vaidyanathan Vignesh , Siebert Dennis , Münzer Andreas , Schilling Gregor , Schreiber Jörg , Thirolf Peter G. , Karsch Stefan , Döpp Andreas 
Published: February 2023

Abstract
The Centre for Advanced Laser Applications in Garching, Germany, is home to the ATLAS-3000 multi-petawatt laser, dedicated to research on laser particle acceleration and its applications. A control system based on Tango Controls is implemented for both the laser and four experimental areas. The device server approach features high modularity, which, in addition to the hardware control, enables a quick extension of the system and allows for automated data acquisition of the laser parameters and experimental data for each laser shot. In this paper we present an overview of our implementation of the control system, as well as our advances in terms of experimental operation, online supervision and data processing. We also give an outlook on advanced experimental supervision and online data evaluation – where the data can be processed in a pipeline – which is being developed on the basis of this infrastructure.
Evaluation of novel triclopyr formulations for control of Old World climbing fern (Lygodium microphyllum)
Authors: Glueckert Jonathan S. , Leary James J. K. , Enloe Stephen F. 
Published: February 2023

AbstractOld World climbing fern [Lygodium microphyllum (Cav.) R. Br] is a smothering vine that has invaded thousands of hectares of wetlands in southern and central Florida, including the Everglades. For more than two decades, the standard management approach in natural areas has been to cut the vines at waist height, leaving climbing rachis to desiccate in the tree canopy (poodle cutting) and subsequently treat all rooted ground cover with a foliar application of a 3% v/v solution of glyphosate. While this is generally effective, there is increasing interest in providing additional control options and more selective treatments. Along with glyphosate, triclopyr is widely used in invasive plant management and may also provide increased selectivity when treating the ground cover. However, it has not been well tested on L. microphyllum, especially the more recently developed acid and choline formulations. In a series of field trials, we compared the acid, amine, and choline formulations of triclopyr against glyphosate as a positive reference and nontreated plots as a negative reference based on control of L. microphyllum at three wetland sites in southern Florida over the period of 2016 to 2020. Significant reductions in L. microphyllum cover were measured at 1 mo after treatment (MAT) and continued to the termination of the studies at 12 and 28 MAT. We found all three triclopyr formulations applied with a single-nozzle backpack sprayer at 5.4 g ae L−1 provided comparable activity to glyphosate applied at 14.4 g ae L−1. There were few differences in L. microphyllum efficacy among the three triclopyr formulations at each site. These results indicate that triclopyr is a suitable alternative to glyphosate for L. microphyllum control in wetland ecosystems. Future research should evaluate triclopyr efficacy on L. microphyllum in varied hydrologic conditions to better refine treatment prescriptions for wetlands.
From adaptive capability to entrepreneurial orientation: the mediating role of network capabilities in the context of SMEs. Findings from SEM and fsQCA
Authors: Bouhalleb Arafet 
Published: February 2023

AbstractTo develop entrepreneurial orientation (EO), small and medium-sized enterprises (SMEs) need to possess managerial and organizational capabilities. In this paper, we posit that adaptive capabilities (AC) and network capabilities (NCs) are assets that allow an SME to distinguish itself and establish an entrepreneurial culture. We investigate the direct effect of AC on EO. Furthermore, we consider the mediating effect of NCs on the AC–EO relationship. The results show that a high level of AC fosters EO. In addition, NCs are shown to be influenced mainly by the SME's ability to cope with change and build relationships with external partners to detect entrepreneurial opportunities.
Moving Towards Inclusive Education: Secondary School Teacher Attitudes Towards Universal Design for Learning in Australia
Authors: Chen Hongyu , Evans David , Luu Betty 
Published: February 2023

AbstractAchieving Sustainable Development Goal 4 is underpinned by the provision of quality inclusive education for all young persons, including persons with disabilities. The universal design for learning (UDL) framework provides the basis for establishing an inclusive pedagogical learning environment in classrooms. However, implementing such an inclusive pedagogical framework continues to be profoundly challenging across all countries, including Australia. Teacher attitude is the most important construct in efforts to create inclusive educational contexts. The aim of this study was to examine secondary school teachers’ attitudes towards the UDL framework in Australia. One hundred and twenty mainstream secondary classroom teachers in Sydney completed an online survey. The mean values and standard deviations of a self-designed UDL framework were calculated to examine teacher attitudes. Correlations and multiple regressions were conducted to verify the relationship between teachers’ attitudes and their background variables. The main results indicated that Australian secondary school teacher attitudes towards the UDL framework were generally positive, although they still had some practical concerns, such as having inflexible ideas about how to provide instructions. The findings provide useful insights for developing professional teacher training to promote inclusive education, where the UDL framework is a lens for interpreting inclusive education.