bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and characterization of an intra‐articular fracture mediated model of post‐traumatic osteoarthritis
Authors: Valerio Michael S. , Pace William A. , Dolan Connor P. , Edwards Jorge B. , Janakiram Naveena B. , Potter Benjamin K. , Dearth Christopher L. , Goldman Stephen M. 
Published: July 2023

AbstractPurposeThis study aimed to develop and characterize a closed intra‐articular fracture (IAF) mediated post‐traumatic osteoarthritis (PTOA) model in rats to serve as a testbed for putative disease modifying interventions.MethodsMale rats were subject to a 0 Joule (J), 1 J, 3 J, or 5 J blunt‐force impact to the lateral aspect of the knee and allowed to heal for 14 and 56 days. Micro‐CT was performed at time of injury and at the specified endpoints to assess bone morphometry and bone mineral density measurements. Cytokines and osteochondral degradation markers were assayed from serum and synovial fluid via immunoassays. Histopathological analyses were performed on decalcified tissues and assessed for evidence of osteochondral degradation.ResultsHigh‐energy (5 J) blunt impacts consistently induced IAF to the proximal tibia, distal femur, or both while lower energy (1 J and 3 J) impacts did not. CCL2 was found to be elevated in the synovial fluid of rats with IAF at both 14‐ and 56‐days post‐injury while COMP and NTX‐1 were upregulated chronically relative to sham controls. Histological analysis showed increased immune cell infiltration, increased osteoclasts and osteochondral degradation with IAF relative to sham.ConclusionBased on results from the current study, our data indicates that a 5 J blunt‐forced impact adequately and consistently induces hallmark osteoarthritic changes to the articular surface and subchondral bone at 56 days after IAF. Marked development of PTOA pathobiology suggest this model will provide a robust testbed for screening putative disease modifying interventions that might be translated to the clinic for militarily relevant, high‐energy joint injuries.
The coloniality of migration and integration: continuing the discussion
Authors: Astolfo Giovanna , Allsopp Harriet 
Published: July 2023

AbstractThe journal Comparative Migration Studies has published a series of articles engaging with critiques of migrant integration. This piece wishes to contribute to such discussion, reflecting back on early critiques of integration as a concept and as a process, and reviewing more recent publications. The aim is to widen the reflection on decolonising the field by including urban postcolonial and southern instances, as well as insights from two funded projects.
Lessons learned from a virtual Community-Based Participatory Research project: prioritizing needs of people who have diabetes and experiences of homelessness to co-design a participatory action project
Authors: Tariq Saania , Grewal Eshleen K. , Booth Roland , Nat B. , Ka-Caleni Thami , Larsen Matt , Lawson Justin , Whaley Anna , Walsh Christine A. , Campbell David J. T. 
Published: July 2023

AbstractIn Community-Based Participatory Research (CBPR), people with shared lived experiences (co-researchers) identify priority needs and work collaboratively to co-design an action-oriented research advocacy project. For this to occur, academic researchers must build mutually respectful partnerships with co-researchers by establishing trust. In the context of the COVID-19 pandemic, our objective was to virtually assemble a group of co-researchers (people with diverse but relevant experiences of homelessness and diabetes) and academic researchers who engaged in the CBPR process to identify a project that would address the difficulties of diabetes management while experiencing homelessness. Co-researchers were recruited to the committee from community homeless-serving organizations. Six co-researchers, one peer researcher and three academic researchers from Calgary, Alberta met virtually for bi-weekly committee meetings, from June 2021 to May 2022 to explore barriers to diabetes management and to complete a priority-setting exercise to determine the focus of our collective project. After reflecting on our virtual CBPR experience we present lessons learned related to: i) technical challenges and logistical considerations, ii) meeting virtually and building rapport, iii) driving engagement, and iv) challenges of transitioning from virtual to in-person meeting format. Overall, the process of conducting a CBPR project virtually to engage a group of co-researchers during a pandemic presents its challenges. However, a virtual CBPR project is feasible and can lead to meaningful experiences that benefit all group members, both from the community and academia.
Humans versus AI: whether and why we prefer human-created compared to AI-created artwork
Authors: Bellaiche Lucas , Shahi Rohin , Turpin Martin Harry , Ragnhildstveit Anya , Sprockett Shawn , Barr Nathaniel , Christensen Alexander , Seli Paul 
Published: July 2023

AbstractWith the recent proliferation of advanced artificial intelligence (AI) models capable of mimicking human artworks, AI creations might soon replace products of human creativity, although skeptics argue that this outcome is unlikely. One possible reason this may be unlikely is that, independent of the physical properties of art, we place great value on the imbuement of the human experience in art. An interesting question, then, is whether and why people might prefer human-compared to AI-created artworks. To explore these questions, we manipulated the purported creator of pieces of art by randomly assigning a “Human-created” or “AI-created” label to paintings actually created by AI, and then assessed participants’ judgements of the artworks across four rating criteria (Liking, Beauty, Profundity, and Worth). Study 1 found increased positive judgements for human- compared to AI-labelled art across all criteria. Study 2 aimed to replicate and extend Study 1 with additional ratings (Emotion, Story, Meaningful, Effort, and Time to create) intended to elucidatewhypeople more-positively appraise Human-labelled artworks. The main findings from Study 1 were replicated, with narrativity (Story) and perceived effort behind artworks (Effort) moderating the label effects (“Human-created” vs. “AI-created”), but only for the sensory-level judgements (Liking, Beauty). Positive personal attitudes toward AI moderated label effects for more-communicative judgements (Profundity, Worth). These studies demonstrate that people tend to be negatively biased against AI-created artworks relative to purportedly human-created artwork, and suggest that knowledge of human engagement in the artistic process contributes positively to appraisals of art.
Clinicopathological study and management of masses in the sinonasal cavity and nasopharynx: a case series of 42 cases
Authors: Patel Ushma , Chauhan Hetal , Patel Nirmal 
Published: July 2023

Abstract
Background
Different types of space-occupying lesions can arise from the nasal cavity and nasopharynx. They can be neoplastic (benign and malignant) or nonneoplastic lesions producing wide range of clinical symptoms. The correlations of clinical, radiological and histopathological findings are necessary in these types of cases.
The aim of the study is to evaluate clinical behaviours of sinonasal cavity and nasopharyngeal masses, to correlate the radiological and pathological findings of masses, to evaluate the methods for early diagnosis of masses and to determine and evaluate the outcome of sinonasal cavity and nasopharyngeal masses following various modalities of treatment.

Materials and methods
This was a prospective study conducted in a tertiary care hospital of Vadodara, Gujarat. A total 42 cases were included in the study. Clinical, demographic, radiological and histopathological details were noted in each case. Follow-up period was about 3 months to 18 months in the study.

Observation
A total 42 cases were included in the study with 20 benign neoplastic lesions, 19 malignant lesions, and 3 nonneoplastic lesions. The incidence was noted between 8 and 75 years of age with a male to female ratio of 2:23. Angiofibroma was the most common benign neoplastic lesion. Squamous cell carcinoma was the most common malignant lesion noted. Thirty-three patients were successfully operated for the excision of tumour. The most common symptom was nasal obstruction present in 66.67% of cases followed by swelling over local site in 62% of cases followed by nasal discharge in our study.

Discussion
The nasal cavity contains different types of epithelial (squamous, neural, olfactory) and mesenchymal (bone, cartilage, muscle and vascular) tissues. Tumours can arise from any of these tissues. Symptomatology is indistinguishable from nasal polypi, chronic rhinosinusitis and granulomatous diseases of the nose. Utmost care is needed in the examination and diagnosis of these cases before starting the treatment.

Conclusion
Clinical, radiological and histopathological correlations are necessary in sinonasal masses as it will be helpful in deciding the treatment plan and any adjunctive treatment if necessary like chemoradiation in malignant lesions. Continuous follow-up is also necessary to look for patency of nasal cavity, any complication and recurrence.
VCP promotes tTAF-target gene expression and spermatocyte differentiation by downregulating mono-ubiquitylated H2A
Authors: Butsch Tyler J. , Dubuisson Olga , Johnson Alyssa E. , Bohnert K. Adam 
Published: July 2023

ABSTRACT
Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP translocates from the cytosol to the nucleus as germ cells transition into the meiotic spermatocyte stage. Importantly, nuclear translocation of VCP appears to be one crucial event stimulated by testis-specific TBP-associated factors (tTAFs) to drive spermatocyte differentiation. VCP promotes the expression of several tTAF-target genes, and VCP knockdown, like tTAF loss of function, causes cells to arrest in early meiotic stages. At a molecular level, VCP activity supports spermatocyte gene expression by downregulating a repressive histone modification, mono-ubiquitylated H2A (H2Aub), during meiosis. Remarkably, experimentally blocking H2Aub in VCP-RNAi testes is sufficient to overcome the meiotic-arrest phenotype and to promote development through the spermatocyte stage. Collectively, our data highlight VCP as a downstream effector of tTAFs that downregulates H2Aub to facilitate meiotic progression.
An inducible model of chronic hyperglycemia
Authors: Tucker Tori R. , Knitter Courtney A. , Khoury Deena M. , Eshghi Sheida , Tran Sophia , Sharrock Abigail V. , Wiles Travis J. , Ackerley David F. , Mumm Jeff S. , Parsons Michael J. 
Published: July 2023

ABSTRACT
Transgene driven expression of Escherichia coli nitroreductase (NTR1.0) renders animal cells susceptible to the antibiotic metronidazole (MTZ). Many NTR1.0/MTZ ablation tools have been reported in zebrafish, which have significantly impacted regeneration studies. However, NTR1.0-based tools are not appropriate for modeling chronic cell loss as prolonged application of the required MTZ dose (10 mM) is deleterious to zebrafish health. We established that this dose corresponds to the median lethal dose (LD50) of MTZ in larval and adult zebrafish and that it induced intestinal pathology. NTR2.0 is a more active nitroreductase engineered from Vibrio vulnificus NfsB that requires substantially less MTZ to induce cell ablation. Here, we report on the generation of two new NTR2.0-based zebrafish lines in which acute β-cell ablation can be achieved without MTZ-associated intestinal pathology. For the first time, we were able to sustain β-cell loss and maintain elevated glucose levels (chronic hyperglycemia) in larvae and adults. Adult fish showed significant weight loss, consistent with the induction of a diabetic state, indicating that this paradigm will allow the modeling of diabetes and associated pathologies.
A questão da segurança jurídica em securitização da tokenização dos certificados das cédulas de produto rural verde e dos créditos do carbono
Authors: Nogueira Elizete Antunes Teixeira 
Published: July 2023

O objetivo deste estudo consistiu em demonstrar a segurança jurídica no processo de financeirização por meio da securitização da tokenização dos certificados das cédulas de produto rural verde e dos títulos dos créditos do carbono. Realizou-se uma pesquisa exploratória, descritiva e documental com ênfase no marco regulatório das securitizadoras, Lei nº 14.430/22. Concluiu-se que a securitização por tokenização tem potencial para ampliar as alternativas para financiamentos e investimentos por meio de produtos inovadores, como: emissões dos certificados das cédulas de produto rural verde e dos títulos dos créditos do carbono, proporcionando liquidez dos mercados secundários e desenvolvimento sustentável de baixo carbono. Além da segurança jurídica interna, haja vista a alienação fiduciária em garantia por constituir o patrimônio de afetação, sendo necessárias definições legais interjurisdições.
Staining ability of herbal tea preparations on a nano-filled composite restorative material – an in-vitro study
Authors: Narkedamalli Raj Kumar , Muliya Vidya Saraswathi , Pentapati Kalyana Chakravarthy 
Published: July 2023

Background: Discoloration of tooth-colored restorations due to various factors is one of the principal causes behind the failure of aesthetics. There has been an surge in the consumption of herbal beverages in recent times and the dietary factors play a potential role in the discoloration tooth-coloured restorations. This study was done to juxtapose the staining ability of green tea (GT), moringa tea (MT), and hibiscus tea (HT) on a nano-filled composite restorative material. Methods: The study was conducted in-vitro on composite samples prepared using moulds. 112 discs were prepared from FiltekTM Z350XT composite using a brass mould lined with mylar strips. Samples were divided into GT, MT, HT, and artificial saliva (AS) groups and immersed in freshly prepared beverages for 15 minutes each day for 45 days. Digital reflectance spectrophotometer was utilized to record color at baseline, 30, and 45 days. Repeated-measures ANOVA with a post-hoc Bonferroni test was used to compare groups within each group. ANOVA with a post-hoc Games Howell test was used to compare mean differences in ΔE among the groups. Results: Maximum discoloration was observed in the GT, followed by HT and MT, with the least being in the AS group at the end of 30 and 45 days (P<0.001 and P<0.001) respectively. Conclusions: The universal nano-filled composite material showed clinically detectable discoloration when exposed to Green Tea, Hibiscus Tea, and Moringa Tea which increased with time. Herbal beverages have the potential to cause discoloration of the composite resin which is often the choice of material for anterior aesthetic restorations.
The influence of bipolar disorder medication on sexual performance
Authors: Chyćko Małgorzata , Czarnota Julia , Cichoń Katarzyna , Kromer Agata , Łapaj Monika , Zapała Magdalena Alicja , Środoń Agnieszka , Cholewa Małgorzata Maria , Gawryś Agnieszka , Wilk Joanna 
Published: July 2023

Sexual performance is one of the key aspects of good quality of life, both in healthy people and patients suffering from various mental disorders. Besides many reasons causing poor sexual performance, like mental condition itself, medication can alter one's ability to achieve satisfaction in sex. Sexual dysfunction is listed among one of side effects of psychotropic medications. Aim of this work is to determine an influence of pharmacotherapy on sexual function in patients with bipolar disorder.
Results: Pharmacotherapy in patients suffering from bipolar disorder can cause a multitude of side effects, including malfunction in sexual performance. Extent of severity in poor sexual life depends on many factors among which are: type of drug taken, whether there are one or more drugs taken at the same time. Seems to be observed that quetiapine shows the least negative effect on sexual performance. Additionally, highest risk of sexual malfunction is observed in patients with polytherapy.
Conclusion: Besides topics investigated in the following research, there are additional factors like duration and severity of the disease, gender and age. There are many variables needed to be taken into consideration, but there is potential of choosing proper medication for a patient with least possible side effects and to allow them to perform more successful sex life, which directly corresponds with better quality of life.
Enhancing the Reach of Socially Missioned Nonprofits: Insights from a TOC-LP Application
Authors: McKie Erin C. , Ahire Sanjay Laxman 
Published: July 2023

Socially missioned nonprofit organizations exist to connect at-risk populations to critical healthcare, food, and financial services. However, these organizations face several internal (resource infrastructure, management capability) and external (multiple stakeholders, client demographics and capabilities) constraints within which they must work to attain their goal of helping people in need. The extant academic literature offers a variety of solutions to such allocation problems for use in for-profit organizations. Yet noted differences in the operational systems of for-profit and nonprofit operations limit practitioners’ capabilities to readily leverage these tools. Thus, in this paper, we extend the applicability of classic resource allocation principles to the context of nonprofit operations’ outreach efforts. We describe a detailed case study analysis at one nonprofit organization (SC Thrive) wherein we implemented the theory of constraints–linear programming framework to help maximize the effectiveness of outreach initiatives carried out by the organization. Based on the results from our stepwise, nonlinear yield model, SC Thrive is now capable of doubling the annual number of applications submitted by potential beneficiaries for assistance services. History: This paper was refereed.
Prehospital anaesthesia by a helicopter emergency medicine service: a review
Authors: O'Neill Ronan , Topping Andrew , Monaghan Darren , O'Rorke Glenn , Hay Philip , McLaughlin Russell , Mitchell Hannah , McFetridge Lisa , Wolfe Julia 
Published: July 2023

Background: The Northern Ireland (NI) Ambulance Service launched its helicopter emergency medical service (HEMS) in 2017. Aims: This paper reviews the first 200 cases of prehospital emergency anaesthesia (PHEA). Methods: A retrospective review of the NI HEMS intubation database between 29 July 2017 and 28 February 2021 was conducted. Findings: PHEA was delivered as rapid sequence intubation (RSI). There was a 100% RSI success rate. The mean 999 call to RSI time was 65.9 minutes (median=61 minutes), with 14.6% of procedures carried out within the National Institute for Health and Care Excellence target of 45 minutes or less. The first pass oral intubation rate was 89.3%. There was a significant difference in the number of male compared to female patients (men=145; women=55; P≤0.0001). Conclusion: PHEA delivery by the HEMS since it was set up has been successful provided in a safe, robust manner. Reducing the 999 call to RSI time in line with the National Institute for Health and Care Excellence target was identified as an area for development.
Screening for Chagas disease from the electrocardiogram using a deep neural network
Authors: Jidling Carl , Gedon Daniel , Schön Thomas B. , Oliveira Claudia Di Lorenzo , Cardoso Clareci Silva , Ferreira Ariela Mota , Giatti Luana , Barreto Sandhi Maria , Sabino Ester C. , Ribeiro Antonio L. P. , Ribeiro Antônio H. 
Published: July 2023

Background
Worldwide, it is estimated that over 6 million people are infected with Chagas disease (ChD). It is a neglected disease that can lead to severe heart conditions in its chronic phase. While early treatment can avoid complications, the early-stage detection rate is low. We explore the use of deep neural networks to detect ChD from electrocardiograms (ECGs) to aid in the early detection of the disease.

Methods
We employ a convolutional neural network model that uses 12-lead ECG data to compute the probability of a ChD diagnosis. Our model is developed using two datasets which jointly comprise over two million entries from Brazilian patients: The SaMi-Trop study focusing on ChD patients, enriched with data from the CODE study from the general population. The model’s performance is evaluated on two external datasets: the REDS-II, a study focused on ChD with 631 patients, and the ELSA-Brasil study, with 13,739 civil servant patients.

Findings
Evaluating our model, we obtain an AUC-ROC of 0.80 (CI 95% 0.79-0.82) for the validation set (samples from CODE and SaMi-Trop), and in external validation datasets: 0.68 (CI 95% 0.63-0.71) for REDS-II and 0.59 (CI 95% 0.56-0.63) for ELSA-Brasil. In the latter, we report a sensitivity of 0.52 (CI 95% 0.47-0.57) and 0.36 (CI 95% 0.30-0.42) and a specificity of 0.77 (CI 95% 0.72-0.81) and 0.76 (CI 95% 0.75-0.77), respectively. Additionally, when considering only patients with Chagas cardiomyopathy as positive, the model achieved an AUC-ROC of 0.82 (CI 95% 0.77-0.86) for REDS-II and 0.77 (CI 95% 0.68-0.85) for ELSA-Brasil.

Interpretation
The neural network detects chronic Chagas cardiomyopathy (CCC) from ECG—with weaker performance for early-stage cases. Future work should focus on curating large higher-quality datasets. The CODE dataset, our largest development dataset includes self-reported and therefore less reliable labels, limiting performance for non-CCC patients. Our findings can improve ChD detection and treatment, particularly in high-prevalence areas.