bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resection margin involvement after endoscopic excision of malignant colorectal polyps: definition of margin involvement and its impact upon tumour recurrence
Authors: Scott Nigel , Cairns Alison , Prasad Padmini , Rotimi Olorunda , West Nicholas P , Sanni Latifu , Rizig Muaaz , Sood Ruchit , Rembacken Bjorn J 
Published: March 2023

AimsMalignant polyps are examined to assess histological features which predict residual tumour in the unresected bowel and guide surgical decision‐making. One of the most important of these features is resection margin involvement, although the best definition of margin involvement is unknown. In this study we aimed to investigate three different definitions and determine their impact on clinical outcomes.Methods and resultsOne hundred and sixty‐five malignant polyps removed endoscopically were identified and histological features correlated with either residual tumour in subsequent surgical resections or tumour recurrence following a period of clinical follow‐up. Involvement of the polyp margin by cancer was defined in three different ways and outcomes compared. Tumour recurrence was associated with tumour grade, mucinous histology and resection margin involvement. All three definitions of margin involvement separated polyps into clinically significant categories; however, a margin ≤ 1 mm identified 73% of polyps as ‘high‐risk’ compared with 59.1% when involvement was defined as tumour within the zone of coagulation artefact at the polyp base or 50% when tumour was present at the margin. All three ‘low‐risk’ groups had a locoregional recurrence rate < 6.5%.ConclusionsDefinitions of margin involvement for endoscopically removed malignant polyps in the colon and rectum vary between health‐care systems, but a 1‐mm clearance is widely used in Europe and North America. Our results suggest that a 1‐mm margin is unnecessary and should be replaced by a definition based on tumour at the margin or within coagulation artefact at the polyp base.
Acute respiratory infection emergency access in a tertiary care children hospital in Italy, prior and after the SARS‐CoV‐2 emergence
Authors: Ciofi degli Atti Marta , Rizzo Caterina , D'Amore Carmen , Ravà Lucilla , Reale Antonino , Barbieri Maria Antonietta , Bernaschi Paola , Russo Cristina , Villani Alberto , Perno Carlo Federico , Raponi Massimiliano 
Published: March 2023

AbstractBackgroundThe COVID‐19 pandemic has changed the epidemiology of acute respiratory infections (ARIs) in children. The aims of the present study were to describe the epidemiological trend of ARI emergency visits and virology results prior and after the SARS‐CoV‐2 emergence and to estimate the association of ARI emergency department (ED) visits with respiratory viruses.MethodsThis study was conducted at the Bambino Gesù Children's Hospital, a tertiary care children's hospital in the Lazio Region, Italy. The demographic and clinical information of children who accessed the ED and were diagnosed with ARI from January 1, 2018 to June 30, 2022 was retrospectively extracted from the electronic health records. The observed temporal trends in viruses diagnosed from respiratory samples were compared with the number of ARI ED visits over the same period through a multivariable linear regression model.ResultsDuring the study period, there were 72,959 ED admissions for ARIs and 33,355 respiratory samples resulted positive for viruses. Prior to the pandemic, respiratory syncytial virus (RSV) and influenza had a clear seasonal pattern, which was interrupted in 2020. In 2021–2022, RSV reached the highest peak observed during the study period, whereas influenza activity was minimal. The peaks of ARI ED visits corresponded to peaks of influenza, RSV, and rhinovirus in the 2018–2019 and 2019–2020 seasons, to SARS‐CoV‐2 and rhinovirus in 2020, and to RSV and parainfluenza in 2021–2022.ConclusionsARI resulting in ED visits should be included in the ARI disease burden measurement for a more accurate measure of the impact of preventive measures.
Longitudinal association between periodontal condition and glycaemic status in middle‐aged adults: A cross‐lagged panel analysis
Authors: Nasution Dewi L. I. , Furuta Michiko , Li Huihua , Zakaria Myrna Nurlatifah , Takeshita Toru , Peres Marco A. , Yamashita Yoshihisa 
Published: March 2023

AbstractAimTo investigate the existence of a bidirectional temporal relationship between periodontal condition and glycaemic status.Materials and MethodsThis longitudinal study included 2198 participants with mean age 43.4 ± 7.7 years, who underwent dental examinations in Yokohama, Japan, at two time points, 2003–2004 and 2008–2009, at an interval of 5 years. Periodontal condition was assessed by the mean value of probing pocket depth (PPD) and clinical attachment level (CAL). Glycaemic status was assessed by fasting glucose and glycated haemoglobin (HbA1c).ResultsThe cross‐lagged panel models showed the effect of HbA1c at baseline on mean PPD at follow‐up (β = 0.044, p = .039). There was a marginal effect of fasting glucose on the mean PPD (β = 0.037, p = .059). It was similar to the effect of fasting glucose or HbAlc on mean CAL. However, in the opposite direction, no effect of mean PPD or CAL at baseline on fasting glucose or HbAlc at follow‐up was identified.ConclusionsThis study demonstrated a unidirectional relationship between glycaemic status and periodontal condition. The study population, however, had mostly mild periodontitis. Future studies are needed to investigate the effect of periodontal condition on glycaemic status in patients with severe periodontitis.
Effects of monochromatic lights on the melanophores arrangement in the spotted snakehead fish Channa punctata (Bloch, 1793)
Authors: Ali Bulbul , Mishra Abha 
Published: March 2023

AbstractSome freshwater teleost fish have pigment cells whose arrangement and shape are affected by the environment. Natural light has a wide range of light intensity. Fish are sensitive to the background and exposed light colour. Fish body colour is a significant criterion in fixing its market value, whether it is ornamental or edible. By favourable light exposure, a culturist may get a good market value of fish on most ethical grounds. In this study, we recorded the changes in melanophore response with the changes in light colour on Channa punctata. Adult fish were treated with monochromatic lights (darkness, white, blue and red light) for 5 and 28 days. After treatment, their body colour and melanophore size, number, length and the number of dendrites were studied. The results showed a significant influence of monochromatic light on melanophore arrangement in fish skin. The data showed that blue light is appropriate for the overall species colour of photic C. punctata. Continuous black or white light caused severe damage to the fish's appearance.
Scaffold protein RACK1A positively regulates leaf senescence by coordinating the EIN3‐miR164‐ORE1 transcriptional cascade in Arabidopsis
Authors: Masood Jan , Zhu Wei , Fu Yajuan , Li Zhiyong , Zhou Yeling , Zhang Dong , Han Huihui , Yan Yan , Wen Xing , Guo Hongwei , Liang Jiansheng 
Published: March 2023

ABSTRACTPlants have adopted versatile scaffold proteins to facilitate the crosstalk between multiple signaling pathways. Leaf senescence is a well‐programmed developmental stage that is coordinated by various external and internal signals. However, the functions of plant scaffold proteins in response to senescence signals are not well understood. Here, we report that the scaffold protein RACK1A (RECEPTOR FOR ACTIVATED C KINASE 1A) participates in leaf senescence mediated by ethylene signaling via the coordination of the EIN3‐miR164‐ORE1 transcriptional regulatory cascade. RACK1A is a novel positive regulator of ethylene‐mediated leaf senescence. The rack1a mutant exhibits delayed leaf senescence, while transgenic lines overexpressing RACK1A display early leaf senescence. Moreover, RACK1A promotes EIN3 (ETHYLENE INSENSITIVE 3) protein accumulation, and directly interacts with EIN3 to enhance its DNA‐binding activity. Together, they then associate with the miR164 promoter to inhibit its transcription, leading to the release of the inhibition on downstream ORE1 (ORESARA 1) transcription and the promotion of leaf senescence. This study reveals a mechanistic framework by which RACK1A promotes leaf senescence via the EIN3‐miR164‐ORE1 transcriptional cascade, and provides a paradigm for how scaffold proteins finely tune phytohormone signaling to control plant development.
Explaining consumers' progress through life insurance decision states: The role of personal values and consumer characteristics
Authors: Bateman Hazel , Gerrans Paul , Thorp Susan , Zeng Yunbo 
Published: March 2023

AbstractMany people have unsuitable life insurance cover or no cover at all. In this study, we survey consumers about their readiness to purchase life insurance. Consumers rate their own “decision state” from “pre‐aware” of life insurance to “aware,” “interested” or “capable” of deciding to purchase. We also collect data on factors associated with progress along the path to purchase. We find that personal values partly determine life insurance decision states. Values matter in addition to the needs of dependents, bequest intentions, and financial literacy. Consumers who place more value on benevolence and self‐direction are more likely to be aware of life insurance. Our results suggest strategies to promote suitable life insurance cover by targeting factors that help progress through each decision state. Insurance providers could thus prime benevolence and self‐direction in advertising and product information.
Open‐hearted: Preferences for openness in the agreeableness domain
Authors: Robinson Michael D. , Lindquist Jade A. , Irvin Roberta L. 
Published: March 2023

AbstractObjectiveOpen objects encourage interactivity and closed objects discourage it. Repeated experiences with open and closed objects are thought to give rise to spatial concepts that can be used to represent a variety of entities such as societies, others, and the self. The present investigation pursues the idea that preferring that which is open to that which is closed is more compatible with an agreeable mode of interacting with others.MethodThree studies (total N = 901) asked participants whether they preferred “open” or “closed” as spatial concepts. Such preferences were linked to variations in agreeableness, peer perceptions, and daily measures of pro‐social functioning.ResultsOpen‐preferring, relative to closed‐preferring, individuals scored higher in agreeableness (Study 1) and were rated by peers as interpersonally warmer (Study 2). Open preferences varied within and across persons in a daily diary protocol and, in both cases, higher levels of open preference were linked to higher levels of pro‐social feeling (Study 3).ConclusionThe findings point to a fundamental component of spatial orientation that plays a significant role in encouraging (open) or discouraging (closed) warm, interactive relations with others.
Testing the equivalence of the aversive core of personality and a blend of agreeableness(‐related) items
Authors: Horsten Luisa K. , Thielmann Isabel , Moshagen Morten , Zettler Ingo , Scholz David , Hilbig Benjamin E. 
Published: March 2023

AbstractObjectiveThere is an ongoing debate in personality research whether the common core of aversive (“dark”) traits can be approximated by or even considered equivalent to one of the constructs that have been labeled “Agreeableness”. In particular, it has been suggested that the low pole of (what we term) AG+, a broad blend of Big Five Agreeableness and the HEXACO factors Honesty‐Humility, Agreeableness, and Altruism, is essentially equivalent to the Dark Factor of Personality (D). Based on theoretical differences, we herein test empirically whether D and AG+ are isomorphic.MethodsSelf‐report data on D, AG+, and eight criterion measures reflecting justifying beliefs, inflicting disutility on others, and affiliative tendencies were collected in a pre‐registered study (N = 1156) and analyzed via confirmatory factor modeling.ResultsResults speak against unity of D and AG+ (35% shared variance) and support the notion that D subsumes a broader range of aversive content (i.e., justifying beliefs and inflicting disutility on others) than AG+, which, in turn, subsumes a slightly broader range of non‐aversive, affiliative tendencies.ConclusionWe conclude that AG+ is non‐equivalent to the common core of aversive traits, D.
Using machine learning to identify early predictors of adolescent emotion regulation development
Authors: Van Lissa Caspar J. , Beinhauer Lukas , Branje Susan , Meeus Wim H. J. 
Published: March 2023

AbstractAs 20% of adolescents develop emotion regulation difficulties, it is important to identify important early predictors thereof. Using the machine learning algorithm SEM‐forests, we ranked the importance of (87) candidate variables assessed at age 13 in predicting quadratic latent trajectory models of emotion regulation development from age 14 to 18. Participants were 497 Dutch families. Results indicated that the most important predictors were individual differences (e.g., in personality), aspects of relationship quality and conflict behaviors with parents and peers, and internalizing and externalizing problems. Relatively less important were demographics, bullying, delinquency, substance use, and specific parenting practices—although negative parenting practices ranked higher than positive ones. We discuss implications for theory and interventions, and present an open source risk assessment tool, ERRATA.
Biallelic known and novel DCDC2 variants in cholestatic liver disease: Phenotype–genotype observations in four children
Authors: Azabdaftari Aline , Sczakiel Henrike L. , Danyel Magdalena , Kohlmaier Benno , Mache Christoph J. , Stalke Amelie , Pfister Eva‐Doreen , Thumfart Julia , Henning Stephan , Knisely A. S. , Bufler Philip 
Published: March 2023

AbstractNeonatal sclerosing cholangitis (NSC) is associated with progressing biliary fibrosis that often requires liver transplantation in childhood. Several recent studies have identified variants in DCDC2, encoding doublecortin domain‐containing protein 2 (DCDC2), expressed in primary cilia, that accompany syndromic disease and NSC. We report four patients with hepatobiliary disease associated with two novel homozygous or compound heterozygous variants in DCDC2. Three patients with protein‐truncating variants in DCDC2, expressing no DCDC2, presented with the originally described severe hepatic phenotype in infancy. One patient with a novel homozygous DCDC2 missense variant shows a markedly milder phenotype only manifest in childhood and with retained DCDC2 expression. Concomitant nephronophthisis is present in three patients and learning disability in two. This report widens the phenotypic spectrum of DCDC2‐associated hepatobiliary disease. Testing for DCDC2 expression and DCDC2 variants should be included in the evaluation of cholangiopathy of unknown aetiology in childhood as well as in infancy.
Associations of serum uric acid levels with liver disease‐related morbidity and mortality: A prospective cohort study of the UK Biobank
Authors: Liu Zhening , Huang Hangkai , Xie Jiarong , Xu Chengfu 
Published: March 2023

AbstractBackground and AimsThe association of serum uric acid (SUA) levels with liver‐related morbidity and mortality remains undetermined. Therefore, we aimed to explore the association of SUA levels with liver‐related morbidity and mortality.MethodsThe present cohort study included 459 619 adults from the UK Biobank. Multivariable Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of SUA levels with morbidity and mortality of overall liver disease. Mendelian randomization (MR) analyses were conducted to explore the underlying causality. A polygenic risk score was generated to assess whether there was a gene‐exposure interaction.ResultsDuring a median follow‐up of 12.6 years, 14 302 nonfatal and 609 fatal cases of overall liver disease were identified. Compared to individuals in the lowest quartile, the HRs (95% CI) of incident overall liver disease were 1.08 (1.02–1.14), 1.13 (1.07–1.20) and 1.44 (1.36–1.53) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. Similarly, the HRs (95% CI) of liver disease‐associated mortality were 1.09 (0.78–1.52), 1.55 (1.14–2.13) and 1.96 (1.42–2.69) for individuals with SUA levels in quartiles 2, 3 and 4 respectively. The MR results did not support the causal association of SUA levels with liver disease. In addition, there was a significant modification effect of the polygenic risk score on the association of SUA levels with incident overall liver disease (pinteraction = .003).ConclusionsHigher SUA levels were significantly associated with an increased risk of overall liver disease morbidity and mortality.
A call for total nursing role reformation: Perceptions of Ghanaian nurses
Authors: Laari Luke , Duma Sinegugu Evidence 
Published: March 2023

AbstractNurses in Ghana believe that training, practise, practitioner and policy reforms are required for total nursing profession reform to be effective. Their views for role reformation in the nursing profession, which is currently needed, are not only academic but also clinically relevant in the pursuit of health equity and quality nursing care. We explored and described nurses’ views on their roles in the profession using data collected from 24 professional nurses in three regional hospitals in Ghana. Using an inductive descriptive qualitative design, data were gathered and analysed using a qualitative content analysis to describe the views of the nurses. Four major themes, namely practise reforms, practitioner reforms, training reforms and policy reforms have emerged in relation to role reformation in the nursing profession. Three strategic areas, practitioner attitudes, new training modalities and policy realignment, must be reviewed and remodelled for better positioning of the nursing profession before its entire role reformation.
A quality improvement intervention to decrease the decline in renal function in pediatric liver transplant recipients
Authors: Batsis Irini , Elisofon Scott , Ferguson Michael , Jonas Maureen , Kimball Brendan , Lee Christine , Mitchell Paul , Fawaz Rima 
Published: March 2023

AbstractBackgroundChronic kidney disease (CKD) impacts long‐term morbidity in pediatric liver transplant (LT) recipients. The prevalence of estimated glomerular filtration rate (eGFR) < 90 mL/min/1.73 m2 (eGFR < 90) at our institution was 25% at 1 year post‐LT; thus, quality improvement (QI) project was initiated, aiming to decrease the prevalence of eGFR < 90 by at least 20% at 1 year‐post LT.MethodsChildren post‐LT under 19 years from 2010 to 2018 were included. Three QI interventions were implemented starting 1/2016: documentation of blood pressure percentile (BP%) and eGFR, documentation of a kidney management plan if either was abnormal, and amlodipine initiation prior to hospital discharge after LT. We compared the prevalence of eGFR < 90 at 3, 12, and 24 months after LT in the pre‐ and post‐intervention period.Results68 patients in pre‐ and 42 in post‐intervention periods met inclusion criteria. Pre‐intervention BP%, eGFR, and kidney management plan were documented at 25%, 10%, and 22%, compared to 71%, 83%, and 71% post‐intervention, respectively. 22% of patients were started on amlodipine prior to discharge from LT in the pre‐ versus 74% in the post‐intervention period. Prevalence of eGFR < 90 at 3 m post‐LT was 19% in pre‐ versus 14% in the post‐intervention period (p = .31); at 12 months 24% versus 7% (p = .01) and at 24 months 16% versus 6% (p = .13), respectively. Significant non‐modifiable risk factors for eGFR < 90 were malignancy (RR = 4.5, p < .0001), metabolic disorder (RR = 2.6, p = .02), and age at transplant (7% increased risk per year of age, p = .007).ConclusionBy improving documentation of BP%, eGFR, and kidney management plan, the prevalence of eGFR < 90 was decreased by a relative 74% and 60% at 12 and 24 months post‐LT, respectively.
Survey of pediatric transplant center practices regarding COVID‐19 vaccine mandates for transplant candidates and living donors and use of COVID‐19‐positive deceased organs
Authors: Feldman Amy G. , Beaty Brenda , Everitt Melanie , Goebel Jens , Kempe Allison , Pratscher Lauren , Danziger‐Isakov Lara A. 
Published: March 2023

AbstractBackgroundCOVID‐19 vaccine is recommended for individuals ages ≥6 months; however, whether vaccination should be mandated for transplant candidates and living donors remains controversial. This study assessed COVID‐19 policies at US pediatric solid organ transplant centers.MethodsA 79‐item survey was emailed between March and April 2022 to 200 UNOS Medical Directors detailing center COVID‐19 vaccine policies for transplant candidates and living donors and use of grafts from COVID‐19‐positive deceased donors.ResultsThe response rate was 77% (154/200). For children aged 5–15 years, 23% (35/154 centers) have a COVID‐19 vaccine mandate, 27% (42/154) anticipate implementing a future mandate, and 47% (72/154) have not considered or do not anticipate implementing a mandate. For children ≥16 years, 32% (50/154 centers) have a COVID‐19 vaccine mandate, 25% (39/154) anticipate implementing a future mandate, and 40% (62/154) have not considered or do not anticipate implementing a mandate. The top two reasons for not implementing a COVID‐19 vaccine mandate were concerns about penalizing a child for their parent's decision and worsening inequities in transplant. Of 85 kidney and liver living donor centers, 32% (27/85) require vaccination of donors. Twenty percent (31/154) of centers accept organs from COVID‐19‐positive deceased donors.ConclusionsThere is great variation among pediatric SOT centers in both the implementation and details of COVID‐19 vaccine mandates for candidates and living donors. To guide more uniform policies, further data are needed on COVID‐19 disease, vaccine efficacy, and use of grafts from donors positive for COVID‐19 in the pediatric transplant population.
Rare cause of pericardial effusion: ‘Erdheim-Chester disease’
Authors: Imtiaz Haider , Hussein Mohsin , Chan Daniel , Garg Mamta 
Published: March 2023

This report details the case of a woman in her 50s who presented with symptoms of congestive heart failure and raised inflammatory biochemical markers. Her investigations included an echocardiogram, which revealed a large pericardial effusion and a subsequent CT-thorax/abdomen/pelvis showing extensive retroperitoneal, pericardial and periaortic inflammation and soft-tissue infiltration. Genetic analysis of histopathological samples detected a V600E or V600Ec missense variant within codon 600 of the BRAF genewith BRAF variants, confirming the diagnosis of Erdheim-Chester disease (ECD).The patient’s clinical management involved several treatments and interventions with input from a variety of clinical specialties. This included the cardiology team for pericardiocentesis, the cardiac surgical team for pericardiectomy due to recurrent pericardial effusions and finally the haematology team for further specialist treatment with pegylated interferon and consideration of BRAF inhibitor therapy. The patient became stable following treatment with significant improvement in her heart failure symptoms. She remains under regular joint cardiology and haematology team follow-up. The case highlighted the importance of using a multidisciplinary approach to best manage the multisystem involvement of ECD.