bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of comorbid depression and diagnostic workup on diagnosis of physical illness: a randomized experiment
Authors: Isbell Linda M. , Graber Mark L. , Rovenpor Daniel R. , Liu Guanyu 
Published: April 2023

Abstract

Objectives
Patients with mental illness are less likely to receive the same physical healthcare as those without mental illness and are less likely to be treated in accordance with established guidelines. This study employed a randomized experiment to investigate the influence of comorbid depression on diagnostic accuracy.

Methods
Physicians were presented with an interactive vignette describing a patient with a complex presentation of pernicious anemia. They were randomized to diagnose either a patient with or without (control) comorbid depression and related behaviors. All other clinical information was identical. Physicians recorded a differential diagnosis, ordered tests, and rated patient likeability.

Results
Fifty-nine physicians completed the study. The patient with comorbid depression was less likeable than the control patient (p=0.03, 95 % CI [0.09, 1.53]). Diagnostic accuracy was lower in the depression compared to control condition (59.4 % vs. 40.7 %), however this difference was not statistically significant χ2(1)=2.035, p=0.15. Exploratory analyses revealed that patient condition (depression vs. control) interacted with the number of diagnostic tests ordered to predict diagnostic accuracy (OR=2.401, p=0.038). Accuracy was lower in the depression condition (vs. control) when physicians ordered fewer tests (1 SD below mean; OR=0.103, p=0.028), but there was no difference for physicians who ordered more tests (1 SD above mean; OR=2.042, p=0.396).

Conclusions
Comorbid depression and related behaviors lowered diagnostic accuracy when physicians ordered fewer tests – a time when more possibilities should have been considered. These findings underscore the critical need to develop interventions to reduce diagnostic error when treating vulnerable populations such as those with depression.
Left invariant Ricci flat metrics on Lie groups
Authors: Yan Zaili , Deng Shaoqiang 
Published: April 2023

Abstract
In this paper, we apply the double extension process to study left invariant Ricci flat metrics on solvable and non-solvable Lie groups. An inductive method to produce new Ricci flat metrics from the old ones is established. As applications, we prove the following two results:
(i) Every nilpotent Lie group with

dim
⁡

C
⁢

(
G
)

≥

1
2

⁢

(

dim
⁡
G

-
1

)

{\dim\mathrm{C}(G)\geq\frac{1}{2}(\dim G-1)}

admits a left invariant Ricci flat metric.
(ii) Given a Lie group G, there exists a nilpotent Lie group N with nilpotent index at most 2 such that

G
×
N

{G\times N}

admits a left invariant Ricci flat metric. We also construct infinitely many new explicit examples of left invariant Ricci flat metrics on nilpotent Lie groups.
Reconstruction of modified transmission eigenvalues using Cauchy data
Authors: Liu Juan , Liu Yanfang , Sun Jiguang 
Published: April 2023

Abstract
The modified transmission eigenvalue (MTE) problem was introduced in [S. Cogar, D. Colton, S. Meng and P. Monk,
Modified transmission eigenvalues in inverse scattering theory,
Inverse Problems 33 2017, 12, Article ID 125002] and used as a target signature for nondestructive testing. In this paper, we study the inverse spectral problem to reconstruct the modified transmission eigenvalues using Cauchy data. We propose a reciprocity gap functional method and show that the MTEs can be determined by solving some linear ill-posed integral equations. Numerical examples for both absorbing and non-absorbing media are presented to validate the effectiveness and robustness of the proposed method.
Effect of buttering on the wear behavior of the SMA welded hardfacing layer in a low-carbon steel
Authors: Ozdemir Ugur , Sozeri Mustafa , Findik Tayfun , Kilicli Volkan 
Published: April 2023

Abstract
In this study, the effect of the buttering layer (18.5% Cr + 9% Ni) and the chemical composition of the hardfacing filler materials on the microstructure and wear behavior of the structural steel (S355JR) was investigated. The chromium-based hardfacing alloys deposited by shielded metal arc welding (SMAW) have also been investigated to establish the relationship between microstructures and wear properties. The microstructure of hardfacing deposits has been examined by using scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. A linear reciprocating abrasive wear test experiment was conducted on the hardfacing deposits using an Al2O3 ball under constant wear test conditions. The experimental results show that the microstructure of hardfacing deposits consists of martensitic matrix and complex (M7C3) carbides. In addition, the increased chromium concentration of filler materials leads to an increase in the volume fraction of the primary carbides in the matrix of hardfacing deposits. The buttering layer caused the formation of diluted hardfacing deposits. Also, it significantly reduced the hardness and wear rate of hardfacing deposits. Fe14-Fe14 hardfacing deposit has exhibited the best wear properties with a low coefficient of friction.
Study on the Effect of Ultrasonic Wave on the Segregation of Large Size 2A14 Aluminum Alloy Ingot
Authors: Su Sichao , Li Ruiqing , Yang Hongbo , Shu Jian 
Published: April 2023

Abstract
In the casting process of 2A14 aluminum alloy with a diameter of 830 mm, the ingots obtained under the condition of ultrasonic treatment and without ultrasonic treatment were compared and evaluated. For the ingot without ultrasonic treatment, the maximum local concentrations of copper and silicon on the cross section were 5.41 % and 1.22 %, respectively. For the ingot with ultrasonic treatment, the maximum concentrations of copper and silicon were 5.1 % and 1.12 %, respectively, and the reduction of copper and silicon in the center of the ingot was 5.7 % and 8.2 %, respectively. The macro-segregation was improved as a whole. Scanning electron microscopy observation showed that the eutectic structure areas without ultrasonic treatment were 42.3 %, 37.8 %, and 32.4 %, respectively, at 25 mm, 175 mm, and 325 mm from the center of the ingot. For the ingot with ultrasonic treatment, the eutectic structure areas at the corresponding positions were 34.8 %, 32.6 %, and 28.8 %, respectively, which were reduced by 17.7 %, 13.7 %, and 11.1 %, respectively. On the cross section, the average tensile strength, average yield strength, and average elongation of the ingot with ultrasonic treatment were increased by 5.6 %, 6.7 %, and 1.5 %, respectively, compared with the ingot without ultrasonic treatment, which improved the performance of the ingot on the cross section as a whole.
ISOLAMENTO SOCIAL E O ESPAÇO PÚBLICO
Authors: Nascimento Kikuchi Fernando Henrique , Silva Júnior Luiz Gilberto , Ávila Chiarelli Lígia Maria 
Published: April 2023

Nesse estudo o problema de pesquisa centra-se na forma como a pandemia do Coronavírus impactou a apropriação e usos dos espaços públicos por usuários LGBTQIA+. Desse modo, o estudo tem como objetivo avaliar como a pandemia afetou o convívio social da comunidade LGBTQIA+. O Estado Brasileiro é escolhido como estudo de caso e o método escolhido foi o grupo focal, realizado de maneira on-line com participantes de diferentes regiões do país. Os resultados demostram que o espaço urbano é um ambiente heteronormativo e violento, fazendo com que pessoas LGBTQIA+ sejam mais reclusas. O que se observa com esse estudo é que o isolamento social causado pela pandemia do Coronavírus, só aumentou uma tendência natural da pessoa LGBTQIA+ ao enclausuramento. Por fim, conclui-se que o rompimento dessa população com a vida comunitária, que sucede na exclusão e apagamento de suas identidades sociais e de gênero. Por consequência, negando aos indivíduos o direito a cidade.
Novel likely pathogenic variant in NR5A1 gene in a Tanzanian child with 46,XY differences of sex development, inherited from the mosaic father
Authors: Damji Rahim Karim , Alimohamed Mohamed Zahir , Claahsen-van der Grinten Hedi L , Westra Dineke , Hamel Ben 
Published: April 2023

Summary
Pathogenic variants in the nuclear receptor subfamily 5 group A member 1 gene (NR5A1), which encodes steroidogenic factor 1 (SF1), result in 46,XY and 46,XX differences of sex development (DSD). In 46,XY individuals with a pathogenic variant in the NR5A1 gene a variable phenotype ranging from mild to severe is seen, including adrenal failure, testis dysgenesis, androgen synthesis defects, hypospadias and anorchia with microphallus and infertility. We report the clinical, endocrinological and genetic characteristics of a patient with 46,XY DSD with a novel likely pathogenic missense variant in the NR5A1 gene. A retrospective evaluation of the medical history, physical examination, limited endocrinological laboratory analysis and genetic analysis with DSD gene panel testing was performed. A 1.5-month-old individual was referred with ambiguous genitalia. The karyotype was 46,XY. The endocrinological analyses were within normal male reference including a normal response of cortisol within an adrenocorticotropic hormone test. A novel heterozygous missense variant c.206G>C p.(Arg69Pro) in the NR5A1 gene was detected. This variant was present in mosaic form (~20%) in his unaffected father. Because another missense variant at the same position and other missense variants involving the same highly conserved codon have been reported, we consider this NR5A1 variant in this 46,XY DSD patient as likely pathogenic in accordance with the ACMG/AMP 2015 guidelines causing ambiguous genitalia but no adrenal insufficiency. This variant was inherited from the apparently unaffected mosaic father, which might have implications for the recurrence risk in this family.

Learning points

The importance of performing trio (patient and parents) sequencing is crucial in pointing out the origin of inheritance.

In a 46,XY differences of sex development patient, a normal adrenal function does not rule out an NR5A1 mutation.

With the support of a dedicated overseas institute partnership, we could solve this complex clinical case by molecular diagnosis in a resource-limited setting.
La Amazonía y el la arte del ingreso en la crisis ambiental
Authors: Da Costa Jodival Mauricio , Da Silva Edilene Lira 
Published: April 2023

Two objectives are integrated in this work. The first objective is to discuss the diffusion of values regarding social-environmental responsibility in the current public sphere and how they confer comparative advantages in obtaining differentiated income by companies. The second objective is to apply this discussion to the Amazon by exemplifying the relationship that Natura company develops with traditional Pan-Amazon communities, as well as the notion of sustainability and how the Amazon can be a strategic region when it comes to environmental crises. The methodology used was based on scientific articles, magazine publications directly linked to the environmental balance of the companies and reports of the Natura company that were published in their website. We concluded that the way to produce market singularities is increasingly due to the combination of production and value diffusion in the public sphere, including the symbolic appropriation of the strategic Spaces of production.
Evaluation of Station Timing Errors from Demeaned Arrival Time Delays
Authors: Daniel Guillaume , Arroucau Pierre 
Published: April 2023

ABSTRACT
We present an analytical solution for the evaluation of timing errors at seismological stations. The method makes use of differential P- and S-wave arrival time measurements demeaned over a network that recorded a set of densely located seismic events. In this configuration, one can assume coincident P and S ray paths between sources and receivers, and cancel out dependencies associated with absolute event origin times, event locations, and P- or S-wave velocities in the problem. Relative timing errors can be obtained by linear inversion, using only a limited amount of input data: differential P- and S-wave arrival times, and a local VP/VS ratio. By setting at least one reference station in the network, supposed to be devoid of any timing error, one can retrieve reliable timing errors for other stations. We validate the approach against synthetic and real data. We also analyze the sensitivity of results on errors in the input data. Although picking uncertainties do affect the variability of estimates, we also identified a significant bias when an incorrect VP/VS ratio is used. However, this bias can be reduced if one uses the optimal VP/VS value that minimizes the root mean square of travel-time residuals. Application of the method to a collection of manually picked arrival times for the 2002–2003 Tricastin, France, earthquake, swarm allowed us to identify nonstationary timing errors from tenth to tens of seconds during the monitoring campaign.
Ewolucja norm prawnych dotyczących urzędu sędziego od Kodeksu Prawa Kanonicznego z 1917 roku
Authors: Bartczak Adam 
Published: April 2023

Sądowe stosowanie prawa opiera się na osobie sędziego. Osobę sędziego jednak charakteryzujemy zwykle przez pryzmat prawa świeckiego. Tymczasem prawo kanoniczne zawiera także normy dotyczące procesów. Kim zatem jest sędzia kościelny? Kto może sprawować ten urząd? Artykuł odpowiada na te pytania, wyznaczając ramy czasowe od 1917 r., tj. od opublikowania pierwszego w Kościele Kodeksu Prawa Kanonicznego, do współczesnego ustawodawstwa. Przeprowadzone badania pokazują dynamikę zmian w tym zakresie, od osoby sędziego, który mógł być jedynie prezbiter, po powrót do aktywnej postawy biskupa diecezjalnego, aż do sędziego w osobie wiernego świeckiego.
Efficacy and Safety of Allogeneic Umbilical Cord-derived Mesenchymal Stem Cells for the Treatment of Complex Perianal Fistula in Crohn's Disease：A Pilot Study
Authors: Wei Juan , Zhang Yufei , Chen Chunyan , Feng Xiaoyue , Yang Zhao , Feng Jing , Jiang Qiong , Fu Jinjin , Xuan Ji , Gao Hong , Liao Lianming , Wang Fangyu 
Published: April 2023

Abstract
Objectives: The aim of the study was to evaluate the efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) for complex perianal fistula in patients with Crohn’s disease (CD).
Methods: This was an open-label, single-arm clinical trial conducted at Jinling Hospital. Adult patients with complex treatment-refractory CD perianal fistulas (pfCD) were enrolled and received a single intralesional injection of 120 million TH-SC01 cells. Combined remission was defined as an absence of suppuration through an external orifice, complete re-epithelization, and absence of collections measured by magnetic resonance image scan (MRI) at 24 weeks after cell administration.
Results: A total of 10 patients were enrolled. Six patients (60.0%) achieved combined remission at 24 weeks. The number of draining fistulas decreased in 9 (90.0%) and 7 (70.0%) patients at weeks 12 and 24 respectively. Significant improvement in Perianal Crohn Disease Activity Index, Pelvic MRI-Based Score, Crohn Disease Activity Index, and quality of life score were observed at 24 weeks. No serious adverse events occurred. The probability of recurrence-free was 70% at week 52.
Conclusion: The study demonstrated that local injection of TH-SC01 cells might be an effective and safe treatment for complex treatment-refractory pfCD after conventional and/or biological treatments fail (ClinicalTrials.gov ID, NCT04939337).
Trial Registration: The study was registered in the Protocol Registration System ClinicalTrials.gov (NCT04939337).
Protection role of Astragalus polysaccharide against Cardiac injury in tnnt2a mutant Zebrafish model of Dilated Cardiomyopathy
Authors: Chang Zhou 
Published: April 2023

Abstract
Background Dilated cardiomyopathy(DCM) is a severe and irreversible heart disease characterized by dilated ventricles and decreased myocardial function. DCM has a poor prognosis and a very low survival rate, with a 5-year mortality rate of 15–50%, and is an important cause of sudden cardiac death and heart failure.Genetic factors play an important role in the pathogenesis of DCM. Mutations in the cardiac troponin T (tnnt2) gene represent an important subset of known pathogenic variants that bind to DCM. However, there are currently few specific drugs available to treat DCM caused by these gene mutations. Astragalus polysaccharide (APS), the main active ingredient of Astragalus mongholicus Bunge(Huangqi), is widely used in China to treat cardiovascular diseases, including DCM. This study explored drugs for the treatment of DCM caused by tnnt2a mutation and found the protective effect of Astragalus polysaccharide on tnnt2a-mutant dilated cardiomyopathy.Methods The tnnt2a-/- mutant zebrafish was used as a DCM model to compare with the APS-administered group. Counting the survival rate and measuring the sinus venosus-bulbus arteriosus (SV-BA) distance to observe changes in cardiac output.Histopathological changes were observed with hematoxylin and eosin (HE) staining and Tunel staining.Transcriptomes of zebrafish DCM group and APS-treated group were investigated by RNA-seq method. qRT-PCR detection of apoptosis-related genes expression.Results We found that APS markedly increased the heart rate and ATP content,significantly inhibited the level of cardiac tissue edema,which are essential for improving survival rate in tnnt2a-/- zebrafish.Moreover,APS interfere some key genes related to muscle fibers,such as titin b (ttnb)and myomesin 3 (myom3),APS intervention significantly participated in Rap1 signaling pathway,PI3K-Akt signaling pathway,Jak-STAT signaling pathway,Wnt signaling pathway.The qRT-PCR results revealed that APS decreased the expression of Bax,Caspase-3,Caspase-9 but incresaed the expression of Bcl-2 in DCM zebrafish.Conclusions Our findings suggest that APS could improve survival rate in Dilated Cardiomyopathy, and has a positive protective effect on the myocardium in the tnnt2a mutant zebrafish model of DCM.
Mercury Dynamics in Organims, Litter, and Soils of the Middle Araguaia Floodplain in Brazil
Authors: Fernandes Iara Oliveira , Monteiro Lucas Cabrera , De Miranda Vinícius Lima , Rodrigues Ygor Oliveira Sarmento , Muniz Daphne Heloisa De Freitas , Paes Ésio De Castro , Bernardi José Vicente Elias 
Published: April 2023

Abstract
Mercury (Hg) is a chemical element that, depending on its concentration, may become toxic to living organisms due to the ability of Hg to bioaccumulate in food chains. In this study, we collected samples of soil, litter and organisms in the Middle Araguaia floodplain, Brazil. Total mercury (THg) concentrations in litter were significantly higher (p < 0.0001) than that in soil, ranging from 10.68 ± 0.55 to 48.94 ± 0.13 and 20.80 ± 1.07 to 55 .19 ± 1.59 ppb, respectively. Total mercury concentration levels in soil showed a linear, inversely proportional relationship with soil organic matter (SOM) contents and soil pH, which is consistent with the geochemical behavior of chemical elements in flooded environments. Ten orders of organisms were identified and the average THg concentrations determined in their bodies were up to 20 times higher than those in soil and litter. We found a significant linear relationship between the levels of THg in litter and the levels found in soil organisms, thereby allowing the prediction of THg concentration levels in soil organisms through the analysis of litter at the sample units. The different dynamics and feeding habits of soil organisms, the concentration of THg in these organisms may be influenced by the course of the river. The bioaccumulation factor (BAF) calculated based on litter indicated the formation of trophic guilds, thus, BAF is a strong indicator of the trophic level of the sample units.
The mesenchymal stem cells play the recovery role of kidney function even in an adverse high sodium environment. An experimental study
Authors: Corrêa Beatriz Santos Geoffroy , Pereira Rafael Canavel , Romão Carolina Martinez , de Sena Claudia Ramos , Furukawa Luzia 
Published: April 2023

Abstract
Background: The high sodium consumption continues, and renal disease development is increasing and is a concern. It is a challenge to overcome these two factors simultaneously to control the increase of acute and chronic renal disease. The present study was designed to experimentally evaluate the mesenchymal stem cells (MSC) treatment in ischemia-reperfusion injury under a chronic high sodium environment.
Method: Eight weeks old male adult Wistar rats received a normal sodium diet (NSD, 1,3%NaCl) or high sodium diet (HSD, 8,0% NaCl), and renal arteria of both kidneys underwent ischemia and reperfusion (IR) for 45 minutes, or they were submitted to the sham procedure for the control group (SHAM). In both diet groups, we delivered 2x106 MSC (IR+MSC) or phosphate buffer solution (IR+PBS) intraperitoneal at the reperfusion moment. Tail blood pressure (tBP), renal function and histology, and stress oxidative were evaluated after 10 weeks of IR or Sham groups.
Results: the blood pressure increased with HSD; however, the MSC treatment decreased it. Although the urea serum increased in the HSD group with MSC treatment, the creatinine clearance increased, and the fraction of sodium excretion decreased. Urine protein and albumin were not different between diet groups. Malondialdehyde (MDA) which evaluates oxidative status, increased, and serum uric acid evaluates anti-oxidative status, decreased with MSC treatment in rats fed HSD. The macrophage (ED1) infiltration decreased with MSC treatment in the renal cortex in both diet groups, while no change was observed in TGF-β.
Conclusion: the mesenchymal stem cells recover kidney function even in an adverse high sodium environment, although the oxidative stress increases. This experimental evidence can contribute to following cellular therapy for acute kidney diseases.
Realizing of ZSM-5 Microspheres with Enhanced Catalytic Properties Prepared from Iron Ore Tailings via Solid-Phase Conversion Method
Authors: Zhang Peng , Chen Xingyue , Wang Yang , Peng Wei , Ren Zhifeng , Li Yihong , He Yibo , Chu Baoshuai 
Published: April 2023

Abstract
The comprehensive utilization of iron ore tailings (IOTs) not only resolved environmental problems, but also brought huge economic benefits. In this study, the synthetic route presented herein provides a novel method for the synthesis of ZSM-5 microspheres from IOTs. The effects of Si/Al molar ratios and the pH of the precursor solution on the formation of zeolite was evaluated by various analytical methods. The catalytic performance of the catalyst prepared by the solid-phase conversion method (denoted as MP-ZSM-5) was evaluated by methanol-to-propylene (MTP) reaction. Compared with the zeolite catalyst that synthesized via the conventional hydrothermal method (denoted as HM-ZSM-5), MP-ZSM-5 not only can achieve a long catalytic lifetime and good selectivity for propylene, but it can also demonstrate superior ability towards coke toleration. In addition, Kissinger-Akahira-Sunose (KAS) model is applied to the TG result to study the template removal process kinetics. The average activation energy values required for the removal of CTAB and TPABr are 201.11±13.42 and 326.88±16.91 KJ∙mol-1, respectively. Furthermore, this result is well coupled with the model-free kinetic algorithms to determine the conversion and isoconversion of the TPABr and CTAB decomposition in ZSM-5, which serves as important guidelines for the industrial production process.