bluuebunny/crossref_metadata_2025_split huggingface dataset:
Covariant light-front approach for $$B_c$$ decays into charmonium: implications on form factors and branching ratios
Authors: Zhang Zhi-Qing , Sun Zhi-Jie , Zhao Yan-Chao , Yang You-Ya , Zhang Zi-Yu 
Published: June 2023

AbstractIn this work, we investigate the form factors of $$B_c$$

B
c

decays into $$J/\Psi , \psi (2S,3S),\eta _c,$$

J
/
Ψ
,
ψ

(
2
S
,
3
S
)

,

η
c

,

$$ \eta _c(2\,S,3\,S), \chi _{c0}, \chi _{c1}, h_c$$

η
c

(
2

S
,
3

S
)

,

χ

c
0

,

χ

c
1

,

h
c

, and X(3872) mesons in the covariant light-front quark model (CLFQM). For the purpose of the branching ratio calculation, the form factors of $$B_c\rightarrow D^{(*)}, D^{(*)}_s$$

B
c

→

D

(

∗
)

,

D
s

(

∗
)

transitions are also included. In order to obtain the form factors for the physical transition processes, we need to extend these form factors from the space-like region to the time-like region. The $$q^2$$

q
2

dependence for each transition form factor is also plotted. Then, using the factorization method, we calculate the branching ratios of 80 $$B_c$$

B
c

decay channels with a charmonium involved in each mode. Most of our predictions are comparable to the results given by other approaches. As to the decays with the radially excited-state S-wave charmonia involved, such as $$\psi (2S,3S)$$

ψ
(
2
S
,
3
S
)

and $$\eta _c(2S,3S)$$

η
c

(
2
S
,
3
S
)

, two sets of parameters for their light-front wave functions, corresponding to scenario I (SI) and scenario II (SII), are adopted to calculate the branching ratios. By comparing with the future experimental data, one can discriminate which parameters are more favored.
Using shallow hydroacoustic data to image seafloor mass transport deposits on the North West Shelf of Australia: links to neotectonics
Authors: Keep M. , Lindhorst K. , Kuhnt W. , Holbourn A. 
Published: June 2023

Abstract
Mass transport deposits have long been known on the Exmouth Plateau, offshore NW Australia, identified in 2D and 3D industry seismic lines. The expedition SO257 in 2017 collected 30 high-resolution, shallow seismic lines along targeted transects on the northern Australian margin. Many of these imaged mass transport deposits, with the top 700–800 m of the section captured in detail not available with industry seismic data. We present nine new high-resolution seismic lines from three separate areas of the North West Shelf. Slides in the Roebuck Basin show complex anastomosing ductile extensional mechanisms, with multiple slip surfaces and no headscarps or adjacent faults. Slides on the Exmouth Plateau have fault control, with surface fault offsets of up to 300 m, indicating seismicity as a likely triggering mechanism. Slumps along the western margin of Western Australia are more limited in extent, associated with surface notches, with indications of previous activity at depth. All areas show a repeated history of mass transport deposits. The area of the active landslide province offshore of NW Australia is far larger than the individual slides recognized on the Exmouth Plateau.
The Mondot-1 Core, Aínsa Basin, Spanish Pyrenees: a deltaic reservoir teaching set with augmented reality
Authors: Marshall John D. , Grötsch Jürgen , Pöppelreiter Michael C. 
Published: June 2023

Abstract
Well Mondot-1 was drilled, cored and logged behind an outcrop of the Eocene Sobrarbe deltaic complex in the Aínsa Basin, Spanish Pyrenees. The data acquired represent a fluvial-dominated delta system prograding over a carbonate slope in the presence of active tectonism, and form part of a basin-to-grain teaching set for subsurface professionals.
This paper highlights the workflow step(s) to move from a 1D core description to 2D and 3D correlations, including some of the pitfalls caused by rapid lateral facies variability, which is a common challenge in subsurface reservoir description. The core allows direct log-to-lithology comparison across a full deltaic succession. In the proximal and distal delta fronts, there are clear differences from the closely adjacent outcrop that are ascribed to lateral facies changes and delta front slumping.
Two approaches to core display are described, as means towards making such data available to a wider audience: an augmented reality display run over a slabbed core, and a virtual whiteboard display carrying easily scalable viewing possibilities. These approaches can be deployed for other cores, allowing visualization and analysis where people are otherwise unable to travel to the physical location, or in circumstances where the core is now inaccessible.
Impact of BMI on Prevalence of Dense Breasts by Race and Ethnicity
Authors: Kerlikowske Karla , Bissell Michael C. S. , Sprague Brian L. , Tice Jeffrey A. , Tossas Katherine Y. , Bowles Erin J. A. , Ho Thao-Quyen H. , Keegan Theresa H. M. , Miglioretti Diana L. 
Published: June 2023

Abstract

Background:
Density notification laws require notifying women of dense breasts with dense breast prevalence varying by race/ethnicity. We evaluated whether differences in body mass index (BMI) account for differences in dense breasts prevalence by race/ethnicity.

Methods:
Prevalence of dense breasts (heterogeneously or extremely dense) according to Breast Imaging Reporting and Data System and obesity (BMI &gt; 30 kg/m2) were estimated from 2,667,207 mammography examinations among 866,033 women in the Breast Cancer Surveillance Consortium (BCSC) from January 2005 through April 2021. Prevalence ratios (PR) for dense breasts relative to overall prevalence by race/ethnicity were estimated by standardizing race/ethnicity prevalence in the BCSC to the 2020 U.S. population, and adjusting for age, menopausal status, and BMI using logistic regression.

Results:
Dense breasts were most prevalent among Asian women (66.0%) followed by non-Hispanic/Latina (NH) White (45.5%), Hispanic/Latina (45.3%), and NH Black (37.0%) women. Obesity was most prevalent in Black women (58.4%) followed by Hispanic/Latina (39.3%), NH White (30.6%), and Asian (8.5%) women. The adjusted prevalence of dense breasts was 19% higher [PR = 1.19; 95% confidence interval (CI), 1.19–1.20] in Asian women, 8% higher (PR = 1.08; 95% CI, 1.07–1.08) in Black women, the same in Hispanic/Latina women (PR = 1.00; 95% CI, 0.99–1.01), and 4% lower (PR = 0.96; 95% CI, 0.96–0.97) in NH White women relative to the overall prevalence.

Conclusions:
Clinically important differences in breast density prevalence are present across racial/ethnic groups after accounting for age, menopausal status, and BMI.

Impact:
If breast density is the sole criterion used to notify women of dense breasts and discuss supplemental screening it may result in implementing inequitable screening strategies across racial/ethnic groups.
See related In the Spotlight, p. 1479
Outcomes in Patients with High-Risk Features after Fixed-Duration Ibrutinib plus Venetoclax: Phase II CAPTIVATE Study in First-Line Chronic Lymphocytic Leukemia
Authors: Allan John N. , Flinn Ian W. , Siddiqi Tanya , Ghia Paolo , Tam Constantine S. , Kipps Thomas J. , Barr Paul M. , Elinder Camburn Anna , Tedeschi Alessandra , Badoux Xavier C. , Jacobs Ryan , Kuss Bryone J. , Trentin Livio , Zhou Cathy , Szoke Anita , Abbazio Christopher , Wierda William G. 
Published: June 2023

Abstract

Purpose:
The CAPTIVATE study investigated first-line ibrutinib plus venetoclax for chronic lymphocytic leukemia in 2 cohorts: minimal residual disease (MRD)-guided randomized discontinuation (MRD cohort) and Fixed Duration (FD cohort). We report outcomes of fixed-duration ibrutinib plus venetoclax in patients with high-risk genomic features [del(17p), TP53 mutation, and/or unmutated immunoglobulin heavy chain (IGHV)] in CAPTIVATE.

Patients and Methods:
Patients received three cycles of ibrutinib 420 mg/day then 12 cycles of ibrutinib plus venetoclax (5-week ramp-up to 400 mg/day). FD cohort patients (n = 159) received no further treatment. Forty-three MRD cohort patients with confirmed undetectable MRD (uMRD) after 12 cycles of ibrutinib plus venetoclax received randomized placebo treatment.

Results:
Of 195 patients with known status of genomic risk features at baseline, 129 (66%) had ≥1 high-risk feature. Overall response rates were &gt;95% regardless of high-risk features. In patients with and without high-risk features, respectively, complete response (CR) rates were 61% and 53%; best uMRD rates: 88% and 70% (peripheral blood) and 72% and 61% (bone marrow); 36-month progression-free survival (PFS) rates: 88% and 92%. In subsets with del(17p)/TP53 mutation (n = 29) and unmutated IGHV without del(17p)/TP53 mutation (n = 100), respectively, CR rates were 52% and 64%; uMRD rates: 83% and 90% (peripheral blood) and 45% and 80% (bone marrow); 36-month PFS rates: 81% and 90%. Thirty-six–month overall survival (OS) rates were &gt;95% regardless of high-risk features.

Conclusions:
Deep, durable responses and sustained PFS seen with fixed-duration ibrutinib plus venetoclax are maintained in patients with high-risk genomic features, with similar PFS and OS to those without high-risk features.
See related commentary by Rogers, p. 2561
Autocrine 17-β-Estradiol/Estrogen Receptor-α Loop Determines the Response to Immune Checkpoint Inhibitors in Non–Small Cell Lung Cancer
Authors: Anobile Dario P. , Salaroglio Iris C. , Tabbò Fabrizio , La Vecchia Sofia , Akman Muhlis , Napoli Francesca , Bungaro Maristella , Benso Federica , Aldieri Elisabetta , Bironzo Paolo , Kopecka Joanna , Passiglia Francesco , Righi Luisella , Novello Silvia , Scagliotti Giorgio V. , Riganti Chiara 
Published: June 2023

Abstract

Purpose:
The response to immune checkpoint inhibitors (ICI) often differs between genders in non–small cell lung cancer (NSCLC), but metanalyses results are controversial, and no clear mechanisms are defined. We aim at clarifying the molecular circuitries explaining the differential gender-related response to anti–PD-1/anti–PD-L1 agents in NSCLC.

Experimental Design:
We prospectively analyzed a cohort of patients with NSCLC treated with ICI as a first-line approach, and we identified the molecular mechanisms determining the differential efficacy of ICI in 29 NSCLC cell lines of both genders, recapitulating patients’ phenotype. We validated new immunotherapy strategies in mice bearing NSCLC patient-derived xenografts and human reconstituted immune system (“immune-PDXs”).

Results:
In patients, we found that estrogen receptor α (ERα) was a predictive factor of response to pembrolizumab, stronger than gender and PD-L1 levels, and was directly correlated with PD-L1 expression, particularly in female patients. ERα transcriptionally upregulated CD274/PD-L1 gene, more in females than in males. This axis was activated by 17-β-estradiol, autocrinely produced by intratumor aromatase, and by the EGFR-downstream effectors Akt and ERK1/2 that activated ERα. The efficacy of pembrolizumab in immune-PDXs was significantly improved by the aromatase inhibitor letrozole, which reduced PD-L1 and increased the percentage of antitumor CD8+T-lymphocytes, NK cells, and Vγ9Vδ2 T-lymphocytes, producing durable control and even tumor regression after continuous administration, with maximal benefit in 17-β-estradiol/ERα highfemale immune-xenografts.

Conclusions:
Our work unveils that 17-β-estradiol/ERα status predicts the response to pembrolizumab in patients with NSCLC. Second, we propose aromatase inhibitors as new gender-tailored immune-adjuvants in NSCLC.
See related commentary by Valencia et al., p. 3832
NCI 7977: A Phase I Dose-Escalation Study of Intermittent Oral ABT-888 (Veliparib) plus Intravenous Irinotecan Administered in Patients with Advanced Solid Tumors
Authors: Cecchini Michael , Walther Zenta , Wei Wei , Hafez Navid , Pilat Mary Jo , Boerner Scott A. , Durecki Diane E. , Eder Joseph P. , Schalper Kurt A. , Chen Alice P. , LoRusso Patricia 
Published: June 2023

Purpose:
Veliparib is a PARP inhibitor (PARPi) with activity in BRCA 1/2/PALB2-deficient tumors. Preclinical observations reveal topoisomerase inhibitors like irinotecan are synergistic with PARPi irrespective of homologous recombination deficiency (HRD), potentially expanding the role for PARPi.

Experimental Design:
NCI 7977 was a multicohort phase I clinical trial evaluating the safety and efficacy of multiple dose schedules of veliparib with irinotecan for solid tumors. In the intermittent veliparib cohort, escalating doses of veliparib were given twice daily at dose level (DL) 1 (50 mg) and DL 2 (100 mg) days 1–4 and 8–11 with irinotecan 100 mg/m2 days 3 and 10 in 21-day cycles.

Results:
Fifteen patients enrolled, 8 of 15 (53%) received ≥4 prior systemic treatments. At DL1, 1 of 6 patients experienced a dose-limiting toxicity (DLT) of diarrhea. At DL2, 9 patients were treated, with 3 unevaluable for DLT, and 2 of 6 evaluable patients experienced a DLT of grade 3 neutropenia. Irinotecan 100 mg/m2 and veliparib 50 mg twice daily was the MTD. No objective responses were observed, although 4 patients had progression-free survival &gt;6 months.

Conclusions:
The MTD of intermittent veliparib is 50 mg twice daily days 1–4 and 8–11 with weekly irinotecan 100 mg/m2 days 3 and 10 every 21 days. Multiple patients experienced prolonged stable disease irrespective of HRD and prior irinotecan. However, due to the toxicities with higher dose intermittent veliparib and irinotecan, this schedule was determined too toxic for further development and the arm was closed prematurely.

Significance:
The combination of intermittent veliparib with weekly irinotecan was deemed too toxic for further development. Future PARPi combinations should focus on agents with nonoverlapping toxicities to improve tolerability. The treatment combination showed limited efficacy with prolonged stable disease observed in multiple heavily pretreated patients, but no objective responses were seen.
Research Hesitancy in the Academe: A Multi-University Study in the Philippines
Authors: Durante Cherry Ann G. , Reynoso Lino C. , Lorenzo Lorenzo C. , Nunez Norma G. , Calixtro Jr. Rufo , Juan Estrella San , Frani Jeeno Jay 
Published: June 2023

ABSTRACT

Cultivating a culture of research in the academe is one of the goals of every institution of higher education in the Philippines. Despite of this, there exists a hesitation among faculty and non-teaching staff in engaging in research and publication. This study explored the reasons behind the decrease of research productivity in the academe in different higher education institutions in the Philippines. Sixteen faculty members from different disciplines were included in the study and were interviewed from November to December 2022. Employing a descriptive phenomenological research design, results showed that the causes of research hesitancy were summarized into four domains, namely: individual, institutional, scientific and professional domains. Under the individual domain, the themes of lack of confidence, lack of motivation, lack of time and lack of interest were identified. The institutional domain enumerated lack of research training, equipment, lack of research programs and funding deficiency. The scientific domain contained themes like lack of knowledge, skill and expertise in conduct of research and writing publishable papers. The professional domain identified themes that revolve around lack of access, lack mentors and lack of collaboration between faculty members. Based on the results of the study, all of the participants expressed the lack of funding support, which included tedious methods of acquiring such funding from the institution and other stakeholders as the primary cause of their hesitancy. Furthermore, participants expressed that individual factors that cause research hesitancy are most difficult to overcome as it pertains to past negative experiences, which led to the reluctance to be trained or to engage in research. The lack of a research culture within the institution was also linked to the absence of a clear research agenda and program, and capacity-building programs geared towards faculty researcher development.
The Bidding Process of The Cebu Provincial Government: A Case Study
Authors: Gabiana Kyll Deither E. , Polinar Mark Anthony N. , Baquero Grace Caroline H. 
Published: June 2023

The government can choose the best and most qualified suppliers or contractors through the bidding process, getting the most value for the money spent by the taxpayers. It encourages government procurement to be effective, efficient, and accountable while ensuring the public receives the most for their money. However, the bidding process, particularly in the government, has gotten negative perceptions from the public. For this reason, this case study wanted to explore the bidding process conducted by the Bids and Awards Committee and their perceived constraints as they reflect on the whole process. Also, adjusting schemes made by the officers to the perceived constraints was discussed. Six (6) key informants were selected by the researchers and interviewed individually. As the study employed Creswell’s method, three themes arose that serve the perceived constraints of the officers: (1) Uninterested Buyers, (2) Unqualified Bidders, and (3) the Availability of Signatory. On top of the themes, all key informants indicated that the Cebu Provincial Government’s bidding process followed RA 9184, known as “The Government Procurement Reform Act.” The researchers drew the conclusion that the Provincial Government should take action to ease these constraints by establishing a transformation program focused on improving the bidding process, notably in vetting the bidders' credentials and required paperwork in advance. As part of the program, the organization should embrace cutting-edge practices like digital project approval as the signatory is preoccupied with other crucial tasks.
Audio –Visual Input for Improving the Cognitive Skills of Grade 10 Students in Araling Panlipunan
Authors: Privado Norielyn R. , Hermosa Jherwin F. 
Published: June 2023

This study aimed to improve the cognitive competence of the students by utilizing audio-visual inputs. The study employed the one-group-pretest-posttest research design under a pre-experimental study participated by 34 Grade Ten (10) respondents in San Isidro National High School who were chosen using the cluster sampling technique. This study utilized a one-group-pretest-posttest research design under a pre-experimental study. Data were gathered using pre-test and post-test questionnaires validated by the experts. Standard deviation and weighted mean were used to analyze the pre-test and post-test scores. T-test was used to calculate the significant difference. The study’s findings revealed a significant difference between the pre-test and post-test scores. Specifically, perception has a .008 significant difference, attention with a .006 significant difference, memory with a .005 significant difference, and logical reasoning with a .007 considerable difference.
Captive breeding unveils hybridisation between aquatic and terrestrial reproductive modes and a reversal reproductive shift within Salamandra salamandra gallaica
Authors: Velo-Antón Guillermo , Figueiredo-Vázquez Clara , Alarcón-Ríos Lucía 
Published: June 2023

Abstract
Bimodal reproductive species offer an excellent opportunity to study the evolution of reproductive shifts, yet are extremely rare among vertebrates. Salamandra salamandra is one of two bimodal amphibian species, showing two viviparity modes: an aquatic (larviparity) and a terrestrial (pueriparity) mode. Although hybridization between larviparous and pueriparous lineages occurs in natural contact zones, their reproductive output is unknown. We conducted a captive breeding experiment to cross pueriparous insular females and larviparous continental males of S. s. gallaica. We first confirmed the reproductive output of the females and used parentage analysis to confirm the parents of the offspring, which resulted in a single group of aquatic larvae. We report, for the first time, direct evidence of F1 hybrids between parity modes in urodeles and a case of parity mode reversal at the individual level. Our study highlights S. salamandra as a bimodal reproductive species that offers exceptional opportunities to understand the evolution of viviparity.
The Influence of Cultural Exchanges along the Silk Road on the Development of Large Stone Portraits in Ancient China
Authors: Chi Guangchao 
Published: June 2023

Abstract
The stone portraits discussed in this paper mainly refer to round carvings and high-relief sculptures of human figures that emphasize realism and a sense of three-dimensionality. The development of stone portraits in the pre-Qin period is briefly reviewed, and their cultural characteristics and causes are analyzed from various perspectives. The Neolithic period was not too late for the germination and start of Chinese portrait sculpture. Due to a series of factors such as geographical conditions, material selection, and cultural philosophy, the development of stone portrait sculpture was not given much attention before the Han Dynasty in China, and the development of realistic round and high-relief portrait art with larger volumes lagged. Along with the exchange and collision between civilizations along the Silk Road, thanks to the widespread dissemination of Buddhist statue art in China since the Wei and Jin Dynasties, the art of large stone statues has taken on a new artistic appearance in terms of subject matter, techniques, types and uses, and has also gained a broader space for expression. Chinese stone portraits have continued to develop and innovate in terms of subject matter and sculpting techniques, and eventually formed an artistic style of portrait sculpture with distinctive national characteristics. This practice of transcending the secular and divine portraits also led to the maturation of secular portrait sculpting techniques such as Stone Wengzhong (翁仲), objectively opening another channel for the diversification of ancient Chinese portrait sculpture. It can be said that the cultural exchanges along the Silk Road had a very important role in promoting the development and maturation of ancient Chinese large stone portrait art.