bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parameters affecting the quality of friction drilled holes and formed thread in austenitic stainless steel AISI 304
Authors: Bassiouny Nada Abdelmoneim , Al-Makky Mohammad , Youssef Helmi 
Published: January 2023

AbstractThe main purpose of this research paper is to improve the quality of the friction-drilled holes and formed thread by investigating the influence of the input working parameters that have not been investigated yet on the quality of the produced bores. Due to lack of research related to the hardness macro- and microstructure of formed threads, experiments were conducted to investigate these important issues. Finally, a tension test was performed to compare the performance of the form tapped thread with the conventionally cut thread. The experiments were conducted on difficult-to-cut material AISI 304 stainless steel workpieces with (2 and 3 mm) wall thicknesses. Tungsten carbide friction drills with diameters (Ø9.2, Ø7.3, and Ø4.5 mm) were used to perform the experiments. The effects of the ratio of workpiece thickness (t) to tool diameter (dT), rotational speed (N), and feed speed (f) on the hole diametral oversize (U), cylindricity error, and collar height were studied. The analysis of variance (ANOVA) showed that the t/d ratio was the most significant factor affecting the mean cylindricity error and the collar height. By comparing the performance of the three tools, it was noticeable that the friction drill Ø7.3 realized better results in terms of mean hole diametral oversize and mean cylindricity error. The elevated temperature associated with high plastic deformation during the processes resulting in fine grains with high hardness values were observed at the heat-affected zone. The longer effective thread length of the formed thread realized higher strength values than the cut thread.
Graphical abstract
The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice
Authors: Moffat Jeffrey J. , Sakhai Samuel A. , Hoisington Zachary W. , Ehinger Yann , Ron Dorit 
Published: January 2023

Abstract
Background
The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release and has been linked to psychiatric disorders including depression and anxiety. We previously showed that male knock-in mice carrying the mouse Methionine homolog (Met68BDNF) exhibit excessive and compulsive alcohol drinking behaviors as compared to the wild-type Val68BDNF mice.

Objective
Here, we set out to determine the potential mechanism for the heightened and compulsive alcohol drinking phenotypes detected in Met68BDNF mice.

Results
We found that male, but not female Met68BDNF mice exhibit social anxiety-like behaviors. We further show that male Met68BDNF mice exhibit a preference for alcohol over social interaction. In contrast, alcohol place preference without an alternative social reward, is similar in male Met68BDNF and Val68BDNF mice. Since the Met68BDNF mice show social anxiety phenotypes, we tested whether alcohol reliefs anxiety similarly in Met68BDNF and Val68BDNF mice and found that male, but not female Met68BDNF mice are insensitive to the acute anxiolytic action of alcohol. Finally, we show that this acute tolerance to alcohol-dependent anxiolysis can be restored by overexpressing wild-type Val68BDNF in the ventral hippocampus (vHC) of Met68BDNF mice.

Conclusions
Together, our results suggest that excessive alcohol drinking in the Met68BDNF may be attributed, in part, to heighted social anxiety and a lack of alcohol-dependent anxiolysis, a phenotype that is associated with malfunction of BDNF signaling in the vHC of male Met68BDNF mice.
Positron emission tomography molecular imaging to monitor anti-tumor systemic response for immune checkpoint inhibitor therapy
Authors: Xing Xiaoqing , Zhao Qing , Zhou Jinyun , Zhou Rui , Liu Yu , Qin Xiyi , Zhang Mingrong , Zhong Yan , Wang Jing , Tian Mei , Zhang Hong 
Published: January 2023

AbstractImmune checkpoint inhibitors (ICIs) achieve a milestone in cancer treatment. Despite the great success of ICI, ICI therapy still faces a big challenge due to heterogeneity of tumor, and therapeutic response is complicated by possible immune-related adverse events (irAEs). Therefore, it is critical to assess the systemic immune response elicited by ICI therapy to guide subsequent treatment regimens. Positron emission tomography (PET) molecular imaging is an optimal approach in cancer diagnosis, treatment effect evaluation, follow-up, and prognosis prediction. PET imaging can monitor metabolic changes of immunocytes and specifically identify immuno-biomarkers to reflect systemic immune responses. Here, we briefly review the application of PET molecular imaging to date of systemic immune responses following ICI therapy and the associated rationale.
Traumatic divergent dislocation of the elbow in the adults
Authors: Gong Maoqi , Wang Hanzhou , Jiang Xieyuan , Liu Yang , Zhou Junlin 
Published: January 2023

Abstract
Purpose
This retrospective study aimed to investigate the clinical outcomes of DDE in adults.

Methods
From September 2010 to March 2020, adult patients with traumatic DDEs admitted to Beijing Chaoyang Hospital and Beijing Jishuitan Hospital were included in this study. Each patient underwent operative or conservative treatment during hospitalization. The clinical and radiological examinations were followed up. The primary outcomes included the Mayo Modified Wrist Score (MMWS), the Mayo Elbow Performance Score (MEPS), the Broberg and Morrey functional index, the Disabilities of the Arm, Shoulder and Hand (DASH) score, and the Visual Analogue Scale (VAS) score that were performed. Post-operative complications and secondary surgery details were also collected.

Results
Of the fourteen patients, clinical and radiographic results were reviewed at a mean of 53.2 months (18 to 110 months) postoperatively. There were 11 men and three women with an average age of 31.5 years (17 to 51 years). At the final follow-up, the average MMWS, MEPS, Broberg and Morrey functional index, and DASH scores were 91.4 points, 93.4 points, 92.6 points, and 10.7 points. The mean VAS at rest and during activities was 0.4 and 1.7 points. Two patients required a secondary procedure due to radial malalignment and elbow contracture, respectively. In addition, two patients were found degeneration.

Conclusions
Within the context of high-energy DDE combined with simultaneous upper limb injuries, our study recommended obtaining the mechanical benefit of the forearm ring with concentric elbow stability. Despite the various and complicated traumatic patterns of DDE, great clinical results could be acquired based on adequate surgical treatments and early rehabilitation training.
Sex‐Based Differences in Survival Among Patients with Acute Abdomen Undergoing Surgery in Malawi: A Propensity Weighted Analysis
Authors: Yohann Avital , Mulima Gift , Kayange Linda , Purcell Laura , Gallaher Jared , Charles Anthony 
Published: January 2023

AbstractIntroductionSex disparities in access to health care in low‐resource settings have been demonstrated. Still, there has been little research on the effect of sex on postoperative outcomes. We evaluated the relationship between sex and mortality after emergency abdominal surgery.MethodsWe performed a retrospective cohort study using the acute care surgery database at Kamuzu Central Hospital (KCH) in Malawi. We included patients who underwent emergency abdominal surgery between 2013 and 2021. We created a propensity score weighted Cox proportional hazards model to assess the relationship between sex and inpatient survival.ResultsWe included 2052 patients in the study, and 76% were males. The most common admission diagnosis in both groups was bowel obstruction. Females had a higher admission shock index than males (0.91 vs. 0.81, p < 0.001) and a longer delay from admission until surgery (1.47 vs. 0.79 days, p < 0.001). Females and males had similar crude postoperative mortality (16.3% vs. 15.3%, p = 0.621). The final Cox proportional hazards regression model was based on the propensity‐weighted cohort. The mortality hazard ratio was 0.65 among females compared to males (95% CI 0.46–0.92, p = 0.014).ConclusionsOur results show a survival advantage among female patients undergoing emergency abdominal surgery despite sex‐based disparities in access to surgical care that favors males. Further research is needed to understand the mechanisms underlying these findings.
The parcel hub scheduling problem with limited conveyor capacity and controllable unloading speeds
Authors: Bugow Stefan , Kellenbrink Carolin 
Published: January 2023

AbstractWe investigate a specific truck scheduling problem at cross-docks in the postal service industry on an operational level aiming to maximise the number of duly parcels assuming fixed departure times of the outbound trucks. The inbound gates and the conveyors as means of transportation inside the hub constitute the bottleneck resources. As a novel extension, we propose flexible unloading speeds to efficiently utilise the scarce resources. We formalise the problem with a mixed integer program and explicitly incorporate controllable unloading speeds of the inbound trucks. We determine the computational complexity and develop a genetic algorithm to efficiently solve the problem. Our investigation focuses on both the performance of the genetic algorithm and the applicability of the results in a real-world environment by implementing scheduling policies in a simulation model that considers individual parcel interactions. Based on our experimental results, we can state that especially in problem settings with scarce conveyor capacities, our approach to incorporate controllable unloading speeds has the potential of significantly increasing the number of duly parcels.
Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney
Authors: Nuñez Paula , Arguelles Juan , Perillan Carmen 
Published: January 2023

AbstractBisphenol A (BPA) is one of the primary chemicals produced by volume worldwide. Extensive literature has raised many concerns about its possible involvement in the pathogenesis of kidney diseases, but its contribution has not been extensively studied. During cellular senescence, the interference of lipofuscin with cellular functions promotes further senescence, causing cellular malfunction. Insulin-like growth factor-1 (IGF-1) plays an important protective role in the setting of kidney injury. The goal of the present work was to evaluate the effects of short-term treatment with low doses of BPA on cellular senescence in adult rat kidneys. Male Wistar rats were injected with vehicle (CONTROL group) or 50 or 500 μg/kg/day of BPA for 1 week (BPA50 and BPA500 groups, respectively). The kidneys were fixed in 4% buffered formaldehyde and embedded in paraffin. Immunohistochemical analyses were performed, and an immunoreactive score (IRS) was calculated. Lipofuscin autofluorescence was used for the study of cellular senescence. The renal cortex showed diffuse autofluorescent lipofuscin signal in the proximal convoluted tubules (PCTs) of males in the BPA50-treated (weak intensity) and BPA500-treated (strong intensity) groups, but not in CONTROL males. Labeling of cortical PCTs with anti-IGF-1 antibodies showed an IRS of 0 in the CONTROL group, but IRSs of 4 and 6 in the BPA50- and BPA500-treated groups, respectively. The present results suggest that low, “safe” doses of BPA induce renal injury, as measured by histological signs of renal changes, increased cellular senescence, and activation of cellular repair systems in PCTs.
Essentially Tight Kernels for (Weakly) Closed Graphs
Authors: Koana Tomohiro , Komusiewicz Christian , Sommer Frank 
Published: January 2023

AbstractWe study kernelization of classic hard graph problems when the input graphs fulfill triadic closure properties. More precisely, we consider the recently introduced parameters closure number c and weak closure number $$\gamma $$
γ
(Fox et al. SIAM J Comput 49(2):448–464, 2020) in addition to the standard parameter solution size k. The weak closure number $$\gamma $$
γ
of a graph is upper-bounded by the minimum of its closure number c and its degeneracy d. For Capacitated Vertex Cover, Connected Vertex Cover, and Induced Matching we obtain the first kernels of size $$k^{\mathcal {O}(\gamma )}$$

k

O
(
γ
)

, $$k^{\mathcal {O}(\gamma )}$$

k

O
(
γ
)

, and $$(\gamma k)^{\mathcal {O}(\gamma )}$$

(
γ
k
)

O
(
γ
)

, respectively. This extends previous results on the kernelization of these problems on degenerate graphs. These kernels are essentially tight as these problems are unlikely to admit kernels of size $$k^{o(\gamma )}$$

k

o
(
γ
)

by previous results on their kernelization complexity on degenerate graphs (Cygan et al. ACM Trans Algorithms 13(3):43:1–43:22, 2017). For Capacitated Vertex Cover, we show that even a kernel of size $$k^{o(c)}$$

k

o
(
c
)

is unlikely. In contrast, for Connected Vertex Cover, we obtain a kernel with $$\mathcal {O}(ck^2)$$

O
(
c

k
2

)

vertices. Moreover, we prove that searching for an induced subgraph of order at least k belonging to a hereditary graph class $$\mathcal {G}$$
G
admits a kernel of size $$k^{\mathcal {O}(\gamma )}$$

k

O
(
γ
)

when $$\mathcal {G}$$
G
contains all complete and all edgeless graphs. Finally, we provide lower bounds for the kernelization of Independent Set on graphs with constant closure number c and kernels for Dominating Set on weakly closed split graphs and weakly closed bipartite graphs.
Regaining enamel color quality using enamel matrix derivative
Authors: Sugaya Hiroyuki , Kurashige Yoshihito , Suzuki Kai , Sakakibara Sayaka , Fujita Yusuke , Islam Syed Taufiqul , Nezu Takashi , Ito Shuichi , Abiko Yoshihiro , Saitoh Masato 
Published: January 2023

AbstractThis study aimed to demonstrate and compare the accuracy of tooth shade selection due to the remineralized enamel crystal with enamel matrix derivative (EMD) in vitro. Etched enamel slices were immersed in four types of mineralization buffers for 16 h. Sodium fluoride (NaF) was added to final concentrations of 1–100 ppm with the mineralization buffer that demonstrated the highest mineralization efficiency. EMD was added to the mineralization buffer containing NaF to see if it has any remineralization capacities. The remineralized enamel crystal was analyzed by SEM and XRD. The tooth shade was evaluated by CIE L*a*b*. The results showed that, without NaF, plate-like nanocrystals were formed on the enamel surface, but with NaF, needle-like nanocrystals were formed. By adding EMD, a layer of well-compacted hydroxyapatite crystals was successfully precipitated onto the natural enamel surface. No significant differences were observed in the L* value of the mineralization surface pre-etching and after mineralization buffer containing NaF and EMD. A new method has been developed to recover the color quality of enamel, as well as to mineralize the tooth enamel by constructing hydroxyapatite crystals with mineralization buffers containing NaF and EMD on the etched tooth surface.
Multi-Disciplinary Management in Rectal Cancer Survivorship: A Clinical Practice Review
Authors: Chan Hilary , Savoie Marissa B. , Munir Amir , Moslehi Javid , Anwar Mekhail , Laffan Angela , Rowen Tami , Salmon Rebeca , Varma Madhulika , Van Loon Katherine 
Published: January 2023

AbstractColorectal cancer (CRC) is the third most common cancer in the USA and worldwide. In the USA, nearly one-third of CRC cases are anatomically classified as rectal cancer. Over the past few decades, continued refinement of multimodality treatment and the introduction of new therapeutic agents have enhanced curative treatment rates and quality of life outcomes. As treatments improve and the incidence of young onset rectal cancer rises, the number of rectal cancer survivors grows each year. This trend highlights the growing importance of rectal cancer survivorship. Multimodality therapy with systemic chemotherapy, chemoradiation, and surgery can result in chronic toxicities in multiple organ systems, requiring a multi-disciplinary care model with services ranging from appropriate cancer surveillance to management of long-term toxicities and optimization of modifiable risk factors. Here, we review the evidence on these long-term toxicities and provide management considerations from consensus guidelines. Specific topics include bowel dysfunction from radiation and surgery, oxaliplatin-induced neuropathy, accelerated bone degeneration, the impact of fluoropyrimidines on long-term cardiovascular health, urinary incontinence, sexual dysfunction, and psychosocial distress. Additionally, we review modifiable risk factors to inform providers and rectal cancer survivors of various lifestyle and behavioral changes that can be made to improve their long-term health outcomes.
Parent involvement in positive behaviour intervention and supports in Australia: teacher and parent/caregiver perspectives
Authors: Rose Michelle , Mooney Mary , Johnston Christine , Parada Roberto H. 
Published: January 2023

AbstractPositive Behaviour Intervention and Supports (PBIS) is a framework for defining, teaching, and supporting appropriate social and academic behaviour in the school setting. This framework is widely implemented across the world, including Australia. Studies evaluating the effectiveness of PBIS confirm a relationship between implementation fidelity and student outcomes. Abundant literature highlights the significance of parent involvement (PI) on children’s social and academic outcomes. However, a consistently and surprisingly under researched component of PBIS is the involvement and influence of parents/caregivers. This article presents the findings of an original qualitative study using stakeholder interviews and artefact analysis to assess parent/caregiver involvement during PBIS implementation in two primary schools in South-West Sydney, Australia. These findings indicate that parent/caregiver involvement in PBIS implementation was interpreted differently by teachers and parents/caregivers and that there is potential for the development of improved methods to engage parents/caregivers more effectively in schools. Reframing parent/caregiver involvement in PBIS to address cultural sensitivities can progressively influence and stabilise this involvement to positively affect the sustainability, effectiveness and fidelity of PBIS. Limitations of the study together with recommendations for future practice are discussed.
How do occupational goals influence adult women’s and men’s decisions to opt out of aspired mathematics-related careers during adolescence?
Authors: Toh Lili , Watt Helen M. G. 
Published: January 2023

AbstractAn explanation for the underrepresentation of women in mathematical fields is the communal goal congruity perspective; that women tend to value communal over agentic goals, perceived to not be afforded by mathematical careers. Less is known about how agentic and communal goals may interact to influence mathematical career trajectories. Analysing a longitudinal dataset, we examined gender differences and combinations of agentic and communal goals, and how goal groups associated with trajectories from adolescent aspirations until actual careers. Among 279 participants followed from secondary school until approximately 20 years later, women valued communal goals higher than men but agentic goals similarly. Despite similar mathematical achievement, the low agentic/high communal goal group was the only group to decline in their choice of a mathematics-related career. There were more women in this group than men, concordant with the communal goal congruity perspective. Implications for future research and educational practice are discussed.
Preparation of simple biodegradable, nontoxic, and antimicrobial PHB/PU/CuO bionanocomposites for safely use as bioplastic material packaging
Authors: Abdo Sayeda M. , Youssef Ahmed M. , El-Liethy Mohamed Azab , Ali Gamila H. 
Published: January 2023

AbstractPlastic waste in Egypt is causing a problem. An innovative solution to reduce this pollution is inevitable. Microalgae were considered a new resource for developing biobased bioplastics. This study aims to prepare a simple biodegradable film able to use in packaging and from polyurethane (PU) nanocomposite with Poly 3-hydroxybutyrate (PHB) in the presence of various concentrations of CuO-NPs. The Poly 3-hydroxybutyrate compounds were extracted from the dominant microalgal species in High rate algal pond Microcystis sp. Algal extracts have antimicrobial activities against Escherichia coli, Salmonella Typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria monocytogenes, Enterococcus faecalis, and Candida albicans. Films prepared from PHB, and PU showed no cytotoxic impact on human tumor cell lines in terms of cell viability. The mechanical properties of the films were studied, and it was found that the final contact angle values were improved from 77° to 87° as CuO-NPs loading raised from 2 to 4%, respectively. XRD displays no difference in the intensity of CuO-NPs peaks by increasing CuO-NPs loading in the PHB/PU matrix. FTIR spectra of all blends were recorded in the range of 400 to 4000 cm−1. Tensile properties were improved with the addition of 40 wt.% PHB.
Comparative bioinformatics analysis of the biosynthetic pathways and key candidate genes of three species, Vitis vinifera, Fragaria vesca and Olea europaea, furnish enzyme sets for the production of pharmaceutically valuable terpenes in heterologous hosts
Authors: Al-Salihi Suhad A. A. , Ford Kathryn L. 
Published: January 2023

AbstractPlants represent a rich repository of taxonomically restricted, yet chemically diverse, secondary metabolites that are synthesised via specific metabolic pathways. Enzyme specificity and biosynthetic gene clustering are the bottleneck of secondary metabolite evolution. As economically important food crops, grape, strawberry, and olive produce many pharmaceutically important molecules; however, their specific biosynthetic pathways remain inaccessible. Our genomic-based analysis of these three species reveal the biosynthetic diversity of their specialised secondary metabolites. We found over 20 BGCs predicted, most of which were characterised in two species, grape and strawberry. Gene annotation of the biosynthetic candidate genes predicted the production of many medically and industrially important compounds including cycloartenol, nerolidol, farnesene and valencene. Although most of the predicted clusters are concentrated in specific genomic positions, some have shown gene duplications in their clusters, which is suggestive of pseudogenes or misassembled genomes. Our genome mining and putative functional analysis of the biosynthetic genes annotated in the three species indicated the evolutionary processes that have shaped their current genetic structure and the structural diversity of their chemical compositions. Revealing the biogenetic background of these natural molecules is a step forward towards the expansion of their chemical diversification via engineering their biosynthetic genes heterologously, as well as the identification of their role in the interaction between those plants and their biotic and abiotic conditions.