bluuebunny/crossref_metadata_2025_split huggingface dataset:
Audio interventions for acute pain management – Protocol of systematic review and meta-analysis
Authors: Tololiu Kevin Efrain , Kurnianto Arie Arizandi , Csokasi Krisztina 
Published: February 2023

Abstract
Background: Undermanaged acute pain contributes to the development of chronic pain and reduced quality of life. Although many complementary therapies have been implemented to manage chronic pain, few studies have investigated these therapies in acute pain. As one of the digital-integrated interventions, audio-related interventions provide multi approaches that potentially affect pain levels, such as suggestive affirmation, educative information, distraction, and relaxation. This study aims 1. to screen and evaluate contemporary literature concerning audio-related interventions application to reduce acute pain, 2. To analyze how the audio interventions affect pain reduction in adults in hospital settings, and 3. To identify the critical aspects of successful audio interventions in pain reduction for adults in a hospital setting.
Method: This study will use Systematic Review and Meta-Analysis by following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines. Six online databases (PubMed, Web of Science, Cochrane library, Ovid Medline & Medline (EBSCOhost), and Embase) will be searched. This review will include RCTs of audio-related interventions to reduce the acute pain level of adults in a hospital setting. Studies published older than ten years ago, presented in non-English languages, combined with other complementary interventions, and presented with the incomplete essential statistical value of pain will be excluded. The meta-analysis will be performed using R and synthesized using the GRADE approach with risk bias assessed with the Cochrane Risk of Bias Assessment tool.
Discussion: This paper will contribute to clinical practice, specifically in the application of complementary therapies or medical technologies associated with audio-related interventions. The findings will provide crucial information on the implication of audio interventions in more effective ways.
Registration: This study is registered in INPLASY protocol 202310002. Doi: 10.37766/inplasy2023.1.0002 and under review of PROSPERO.
Effect of Ionic Spin on the Multiferroic of Orthorhombic Perovskite Structure
Authors: Gao Kaiyang , Shen Jiyu , Lu Zeyi , Mo Jiajun , Liu Guoqing , Wu Zhongjin , Gong Chenying , Xia Yanfang , Liu Min 
Published: February 2023

Abstract
To study the role of the spin of ions in the coupling between ferromagnetism and ferroelectricity in type II multiferroic perovskite, we used the sol-gel method to prepare multiferroic perovskite Er0.9La0.1Cr0.8Fe0.2O3(ELCFO), and through Mössbauer spectrum and magnetic testing, the macroscopic magnetic characteristics of ELCFO are explored. According to the thermal magnetic curve, we analyzed the state and change of each ionic spin in the ELCFO system in different temperature ranges. And we also explore how ionic spin causes the coupling between ferroelectricity and ferromagnetism. This paper will provide a theoretical basis for studying multiferroic perovskite and play a guiding role.
Effect of Risk Factors at Workplace on Aging: A Study based on Mendelian Randomization and Phenome-wide association
Authors: Ma Jingxuan , Lan YaJia , Wang Hongjian 
Published: February 2023

Abstract
Objectives
Numbers of studies have shown that human aging is related to environmental factors, among which workplace is an important living environment in people's life. However, there is still a lack of causal exploration research on the effect of workplace factors on human aging. From the perspective of genetic polymorphism, we explore the association between human aging and risk factors in the workplace,and the possible pathways of aging caused by risk factors in the workplace.
Methods
To systematically explore the association between workplace risk factors and aging, we used a two-sample Mendelian randomization method to examine the association of nine common workplace risk factors with telomere length and accelerated DNA methylation GrimAge clock. We used the corresponding single nucleotide polymorphisms screened as instrumental variables to enable causal associations between exposing to workplace factors and aging.
Results
According to our tests, "Heavy physical work" and "Noise" are associated with telomere length, which shows statistics as OR [95% CI] = -0.136[-0.229, -0.043], p = 0.004 and the OR [95% CI] = 0.014 [0.002, 0.027], p = 0.025) respectively. Meanwhile, the P value of the phenotype "Asbestos" was close to 0.05 (P = 0.059), and the OR value was OR [95%CI] = -1.098[-2.241, 0.044].The factor "diesel exhaust"(ukb-d-22615_2) associated with GrimAge acceleration was OR [95%CI] = 8.238[-0.023, 16.450], p = 0.05.
Conclusions
Our finding suggests that there existing causal relationship between workplace exposure to risk factors (noise, heavy physical activity, fuel engine exhaust) and aging.
Impact of the gut microbiome on immunological responses to COVID-19 vaccination in healthy controls and people living with HIV
Authors: Ray Shilpa , Narayanan Ashwathy , Vesterbacka Jan , Blennow Ola , Chen Puran , Gao Yu , Gabarrini Giorgio , Ljunggren Hans-Gustaf , Buggert Marcus , Manoharan Lokeshwaran , Chen Margaret , Aleman Soo , Sönnerborg Anders , Nowak Piotr 
Published: February 2023

Abstract
Although mRNA SARS-CoV-2 vaccines are generally safe and effective, in certain immunocompromised individuals they can elicit poor immunogenic responses. Among these individuals, people living with HIV (PLWH) have poor immunogenicity to several oral and parenteral vaccines. As the gut microbiome is known to affect vaccine immunogenicity, we investigated whether baseline gut microbiota predicts immune responses to the BNT162b2 mRNA SARS-CoV-2 vaccine in healthy controls and PLWH after two doses of BNT162b2. Individuals with high spike IgG titers and high spike-specific CD4+T-cell responses against SARS-CoV-2 showed low α-diversity in the gut. Here, we showed for the first time that the gut microbial composition influences the response to BNT162b2 in PLWH. Bifidobacterium and Faecalibacterium appeared to be microbial markers of individuals with higher spike IgG titers, while Cloacibacillus was associated with low spike IgG titers. We therefore propose that microbiome modulation could optimize immunogenicity of SARS-CoV-2 mRNA vaccines.
Multi-omics reveals that forage fiber promotes rumen development of pre-weaning calves compared to non-forage fiber
Authors: XU Shengyang , Wang Shuo , Zhao Wei , Bi Yanliang , Diao Qiyu , Tu Yan 
Published: February 2023

Abstract
Background: The rumen development of calves can result in long-term effects on growth, health, and milk yields in adult cattle. Dietary fiber supplement can stimulate rumen development in calves during pre-weaning period. Non-forage fiber can be used as starter fiber to reduce gastrointestinal fill and increase the content of rumen volatile fatty acid (VFA) because of higher biodegradable fiber. Numerous studies revealed that non-forage fiber has no negative effect on pre-weaning calves compared to forage fiber, but few evidences of rumen development were given. It is unclear whether different fiber sources impact the development of rumen in pre-weaning calves. Here, this study investigated the synergistic responses of rumen microbiota, metabolites and epithelium to different fiber source.
Results: Thirty healthy Holstein calves with similar age (4.2 ± 2.3 days) and body weight (39.2 ± 3.6 kg) were allocated to two groups (15 cows per group), and were fed with one of the two diets with different fiber sources, short oat hay (SO), or short soybean hull (SS) for 8 weeks, respectively. At the end of the experiment, 6 calves of each group with similar body weight were selected to slaughter. Observations showed that SO-feeding calves has lengthened and widened rumen epithelial papillae. Metagenomic results revealed that different bacteria responded to different fiber source by different Carbohydrate-active enzymes (CAZymes) (P < 0.05). Metabolomics analysis indicated that “vitamin B6 metabolism” pathway was significantly enriched based on the 22 increased metabolites in the SO calves (P < 0.05, pathway impact > 0.05). The Pyridoxine, 4a-Carbinolamine tetrahydrobiopterin and Gentisic acid were enriched under SO feeding (P < 0.05, VIP > 1). Transcriptome analysis revealed that 129 differentially expressed genes (DEGs) were identified from comparison of the two groups. The DEGs related to transcription, translation and energy metabolism were upregulated (P < 0.05).
Conclusions:The SO feeding (forage fiber) can lead to the enrichment of beneficial metabolites and metabolic pathways, promote the expression of genes related to energy metabolism, transcription and translation, and ultimately promote the development of rumen epithelium. Therefore, in pre-weaning calves production, attention should be paid to the impacts of forage fiber (short oat hay) introduction on rumen morphology and function.
Management and outcomes of traumatic liver injury: a tertiary care center experience
Authors: Alanezi Tariq , Altoijry Abdulmajeed , Alanazi Aued , Aljofan Ziyad , Altuwaijri Talal , Iqbal Kaisor , AlSheikh Sultan , Molla Nouran , Altuwaijri Mansour , Aloraini Abdullah , Altuwaijri Fawaz , Aldossary Mohammed Yousef 
Published: February 2023

Abstract
Background
Trauma is considered a significant public health problem worldwide. Abdominal trauma is generally divided into blunt and penetrating. Blunt trauma could affect any organ, and the sequelae of such injury may not always be clinically apparent. Liver injury is one of abdominal trauma's most critical and fundamental complications. We aimed to investigate the mechanism, type, and extent of injuries for patients with liver trauma and compare the outcomes between operative and non-operative management.
Methods
This retrospective study analyzed data of patients with liver injuries who presented to King Khalid University Hospital, King Saud University from 2016 to 2022. Management included conservative, conservative to laparotomy, laparotomy, and interventional radiological procedures, including hepatic artery angioembolization and percutaneous transhepatic drainage. Injury severity was graded based on the American Association for the Surgery of Trauma (AAST) liver injury scale.
Results
We analyzed 45 liver injury patients, with mean age of 29.3 years and most of them being male (77.8%). The most common injury mechanism was blunt trauma (86.7%), whereas penetrating injuries accounted only for 8.9% of cases. The most dominant type of injury was laceration (95.6%), followed by contusion (28.9%). Regarding liver injury severity, the majority of patients (37.8%) had a grade 3 injury level as per AAST liver injury scale. Among all patients, 31 (68.9%) were hemodynamically stable, whereas 14 patients (31.1%) were unstable, with a mortality rate of 2.2%. Most patients (82.2%) underwent conservative management. Six patients (13.3%) require surgical laparotomy. Two patients (4.4%) who underwent conservative management first needed surgical laparotomy. The complication rate was 24.4%, with delirium being the most common (6, 13.3%), followed by fever and sepsis (3, 6.7%) and acute renal failure, pneumonia, cardiac arrest, biliary leaks, meningitis/seizures, which were all reported in a subset of patients.
Conclusions
Liver trauma is considered a significant public health problem worldwide. The management of traumatic liver injuries has evolved significantly over the years, with the addition of interventional radiological modalities, a more inclined approach toward non-operative management.
Synthesis of the knowledge of braconids in Brazil: list of species, data gaps and spatial biases in the sampling
Authors: Moreira Gleidiany da Costa , Bosco Nicolas Silva , Shimbori Eduardo Mitio , Sobral-Souza Thadeu , Onody Helena Carolina 
Published: February 2023

Abstract
Understanding the distributional patterns of species is a challenge to science, mainly because knowledge of the occurrence of species is often scarce and biased. This study aimed to compile available information on the distribution of braconids in Brazil and evaluate the sampling gaps and biases using accessibility metrics. The full dataset includes 2,280 records of 1,015 species of these wasps in Brazil, distributed in 28 subfamilies and 229 genera. Opiinae is the subfamily containing the largest number of records, while Doryctinae stands out in terms of species richness. The genus with the greatest number of records is Doryctobracon Enderlein 1920, while Opius Wesmael 1835 attracts attention for its number of species. Doryctobracon areolatus (Szépligeti 1911) is the species with the largest number of records in all biomes. Most species records are from the Brazilian Southeast, especially from the Atlantic Forest. Data indicates accessibility bias towards roads, rivers, and urban centers. Implication to the conservation of insects: Our results compile the information available on the distribution of braconids in Brazil and, through them, we examined the extension of deficiencies in the sampling coverage to subsidize future studies and the prioritization of sampling areas, as well as important conservation strategies that are efficient for conservation.
Synthesis of Covalent Thiourea Organic Polymer (CTOP) and Adsorption of Au (Ⅲ)
Authors: Wang Tinglu , Zheng Naixia , Li An , Yang Tao , Hua Jie , Yuan Yongbing , Li Lijun , Zhou Congshan 
Published: February 2023

Abstract
In this paper, the covalent organic polymer of enaminone was modified by thiourea, and the covalent organic polymer of thiourea (CTOP) was synthesized by simple solvothermal method. At 25 ℃, the adsorption capacity of the polymer for trivalent gold ion is 2372.7 mg/g. In the mixed aqueous solution of divalent cadmium ion, trivalent gold ion, divalent copper ion, divalent cobalt ion and divalent nickel ion, CTOP can only adsorb trivalent gold ion, which indicates that CTOP has high selective adsorption performance for trivalent gold ion. In addition, CTOP material still maintains high adsorption performance after five adsorption cycles, which proves that the adsorption material has good reusability. According to the experimental results of adsorption kinetics and thermodynamics, the adsorption process of CTOP for trivalent gold ions conforms to the quasi second order adsorption model and Langmuir adsorption model, that is, the adsorption process of CTOP for trivalent gold ions is single-layer chemical adsorption. CTOP not only has strong adsorption and selectivity to Au (Ⅲ), but also has good reusability. Therefore, it is an ideal environmental functional material, which can be used to separate and enrich trivalent gold ions in wastewater.
Wild boars disturb hair-tube sampling, but adequate replication and inclusion of disturbed tubes retain sampling integrity
Authors: Tomassini Orlando , Pardini Andrea , Aghemo Anna , Baldeschi Benedetta , Favilla Andrea , Bedini Gianni , Petroni Giulio , Giunchi Dimitri , Massolo Alessandro 
Published: February 2023

Abstract
Structure and composition of small mammal assemblages are excellent indicators of habitat quality and often used to study impacts of perturbations such as wildfires on faunal communities. One of the most efficient and widely used tools for assessing small mammalian assemblages are hair-tubes. Despite their efficiency, they are often damaged by non-target species such as wild boar (Sus scrofa). However, the impact of such damage on the use of hair-tubes has apparently never been formally assessed. In this study, wildlife-induced disturbance of hair-tube sampling was quantified in the mountain chain of Monte Pisano (Italy), a fire-prone area. At each site, two hair-tubes were tied together to form a “pan-pipe” and placed in three repetitions. Disturbances were measured, including camera-traps to identify damaging species.
Although approximately 27% (N=164/600) of pan-pipes were disturbed, two pan-pipes per site resulted in 96.5% undisturbed pan-pipes. Unexpectedly, as the most frequently disturbed pan-pipes were those monitored by camera-traps, our rates were considered overestimates. Perhaps this was due to attraction of the wild boars, by means of olfactory/acoustic signals. Boar was the wild species with the greatest impact on pan-pipes, and its impact and rates of all wildlife disturbances did not differ among habitats. Furthermore, displaced tubes were not significantly different from undisturbed tubes in terms of numbers of hairs collected and biodiversity estimates.
To avoid data loss when conducting pan-pipe monitoring, we suggest using at least two pan-pipes per site. Finally, displaced tubes that are retrieved should provide reliable data.
Oil-in-water Pickering emulsions stabilized by nanostructured cellulose: comparison of cellulose nanocrystals and nanofibrils
Authors: Pirozzi Annachiara , Bettotti Paolo , Ferrari Giovanna , Facchinelli Tiziano , D’Amato Elvira , Scarpa Marina , Donsì Francesco 
Published: February 2023

Abstract
Nanostructured celluloses, in the form of nanofibrils (CNFs) and nanocrystals (CNCs), obtained through TEMPO-mediated oxidation, by controlling the intensity of the process (changing catalyst concentration and processing time), were tested in the stabilization of Pickering emulsions, fabricated through high-pressure homogenization (HPH). Results showed that both CNFs and CNCs provided an efficient steric and electrostatic stabilization of the oil-in-water emulsions. Remarkably, the strong inter-droplet interactions, observed when CNFs were used as stabilizers, because of fibrils entanglement in the continuous phase, resulted in a 3D fibrous network emulsion, with higher viscosity than CNCs-stabilized emulsions, and higher tendency towards flocculation. However, the HPH treatment significantly affected the nanofibrils interfacial layer, promoting the emulsifying ability of CNFs, and increasing stability against coalescence. In contrast, CNCs-stabilized emulsions exhibited, along with lower viscosity, higher interfacial activity and emulsion stabilization capability, without any phase separation during 10 months of refrigerated storage. Remarkably, the HPH treatment did not significantly change the emulsifying ability of CNCs. Therefore, it can be concluded that nanocelluloses with tailored emulsifying properties can be easily obtained through the regulation of the process intensity of TEMPO-mediated oxidation of pulp cellulose, opening the way to the production of new ingredients for the food and cosmetic industries.
In vitro evaluation of the effects of Inula viscosa’s different extracts on wound healing and oxidative stress in mouse L929 fibroblast cell line
Authors: Harmankaya Ahmet , Çınar İrfan , Yayla Muhammed , Harmankaya Sezen , Beytur Murat , Öziç Cem 
Published: February 2023

Abstract
This study evaluated the effects of extracts prepared using two different methods (decoction extraction and, Soxhlet ethyl acetate/hexane extraction) from Inula viscosa on H2O2-induced oxidative stress and wound healing model in mouse L929 fibroblast cells. The cytotoxic effect started to disappear statistically (p < 0.05) at concentrations of Soxhlet ethyl acetate/hexane extracts (SoxEHEs) in and below 0.1 mg/mL, while the same effect was observed at concentrations of decoction extracts (DEs) in and below 0.2 mg/mL. Therefore, 0.2 and 0.02 mg/mL concentrations of DE, and 0.1 and 0.01 mg/mL concentrations of SoxEHEs were used. While cell migration was positively affected in all concentrations of the research, statistically significant results (p < 0.05) were obtained from 0.2 mg/mL of DE and 0.1 mg/mL of SoxEHE extracts. Malondialdehyde (MDA) levels were found to be statistically (p < 0.05) decreased, but COL1A1 levels were higher in cell lines treated with oxidative stress + extract than in the cell line treated only with H2O2, and reduced glutathione (GSH) levels were higher in cell lines only treated only with extract than in oxidative stress-induced cell lines. Consequently, it has been observed that the extracts have positive effects on migration and oxidative stress. Therefore, I. viscosa may serve as a new therapeutic agent for wound healing.
Lattice Boltzmann high-performance simulations of decaying isotropic turbulence
Authors: Kareem Waleed Abdel , Mohammed Hadeer , Sherbiny Hamed El , Asker Zafer 
Published: February 2023

Abstract
This study investigates high-performance computing (HPC) strategies for improving and reducing the time consumption of the simulations of turbulent flows in periodic boxes at different resolutions using the lattice Boltzmann method (LBM). Isotropic turbulence is a fundamental problem in fluid dynamics that can be considered a good candidate for examining HPC applications. The LBM is a computational method that can be computationally parallelized, hence proper parallelization and vectorization are provided for reducing data volume and data transfer. Simulations of decaying isotropic turbulence at resolutions starting from 323 to 5123 using the LBM are carried out for these purposes. Clear progress for time reduction is achieved in all cases, while different features of the flow fields are depicted, and their characteristics are discussed. Very thin tubes are visualized, and the energy spectra are studied. More than 88%-time reduction is obtained in favor of the HPC using the same hardware resources with the lattice Boltzmann relaxation time 𝝉 = 0.503. All fields are initialized by a forced turbulent field that was simulated in a previous study using the LBM.
Propyl methacrylate(MPTMS)-intercalatedMg-Al-layered double hydroxide: II.Morphological, thermal propertiesand diffusion behavior
Authors: Berenjegani Reza Mohammadi , Darvishi Reza , Payam Ghasem 
Published: February 2023

Abstract
A series of poly (vinyl chloride) (PVC) composites have been madethrough an in-situ suspension polymerization process in attendanceof 5 wt% of MgAl(NO3) layered double hydroxide (LDH) or 3-(trimethoxysilyl) propyl methacrylate (MPTMS)-intercalated Mg-AlLDH (MPTMS-LDH). The thermal stability and mechanical and phys-ical properties of the prepared composite samples were examined andcompared with the pure PVC. The data obtained from the Brabender®plastograph illustrated that the final PVC grains prepared in atten-dance of MPTMS-LDH have higher thermal stability time and lowerfusion. The fusion degree of PVC particles has been incremented byMPTMS-LDH nanosheet; as a result, it has been observed that alower requirement of temperature/time process. A conventional dehy-drochlorination test proved the improvement of thermal stability. The composite, including MPTMS-LDH, showed a 40% improvement indehydrochlorination rate relative to the pure PVC, this enhance-ment is 12% in comparison with PVC/LDH composite. TGA curvesshow that the 5 and 50% weight loss temperatures of PVC resinshave remarkable growth (∼11 ◦C) with introducing 5 wt% LDH orMPTMS-LDH. The storage modulus of the glassy state(glassy plato)and the Tg of the PVC/MPTMS-LDH is higher than the pure PVCand composite of PVC/LDH. The results of mechanical analysis illus-trated that PVC/LDH-MPTMS composites have larger stiffness andtoughness. The Charpy notched impact strength, tensile strength, andYoung’s modulus of the PVC/LDH-MPTMS composites are signifi-cantly more than the composite of PVC/LDH and the pure PVC.