bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders
Authors: Gutiérrez-Rodelo Citlaly , Martínez-Tolibia Shirlley Elizabeth , Morales-Figueroa Guadalupe Elide , Velázquez-Moyado Josué Arturo , Olivares-Reyes J Alberto , Navarrete-Castro Andrés 
Published: July 2023

AbstractAnxiety and depression disorders are highly prevalent neurological disorders (NDs) that impact up to one in three individuals during their lifetime. Addressing these disorders requires reducing their frequency and impact, understanding molecular causes, implementing prevention strategies, and improving treatments. Cyclic nucleotide monophosphates (cNMPs) like cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), cyclic uridine monophosphate (cUMP), and cyclic cytidine monophosphate (cCMP) regulate the transcription of genes involved in neurotransmitters and neurological functions. Evidence suggests that cNMP pathways, including cAMP/cGMP, cAMP response element binding protein (CREB), and Protein kinase A (PKA), play a role in the physiopathology of anxiety and depression disorders. Plant and mushroom-based compounds have been used in traditional and modern medicine due to their beneficial properties. Bioactive compound metabolism can activate key pathways and yield pharmacological outcomes. This review focuses on the molecular mechanisms of bioactive compounds from plants and mushrooms in modulating cNMP pathways. Understanding these processes will support current treatments and aid in the development of novel approaches to reduce the prevalence of anxiety and depression disorders, contributing to improved outcomes and the prevention of associated complications.
Graphical abstract
A comparative study on transient vibration suppression of magnetic nonlinear vibration absorbers with different arrangements
Authors: Guo Muxuan , Tang Lihua , Wang Hongyan , Liu Haipeng , Gao Shiqiao 
Published: July 2023

AbstractNonlinear vibration absorbers (NVA) using magnets feature ease of implementation and outstanding tunability and have attracted much interest in vibration suppression in recent years. Through configuration design and optimization, magnetic NVA can exhibit different nonlinear characteristics such as monostability, bistability and tristability. This work performs a comprehensive comparative study on the transient vibration suppression performances of the NVAs with four different magnet arrangements based on the cantilever beam design, including the NVA with two repulsive magnets (2RMNVA), two attractive magnets (2AMNVA), three repulsive magnets (3RMNVA) and three attractive magnets (3AMNVA). Based on the dipole–dipole model of magnets, the dynamic model of the system containing different magnetic NVAs is established for numerical simulation and the key parameters of each NVA are optimized under different excitation levels. The influence of parameters on different magnetic NVAs is investigated. Based on the optimization configurations, the rate of the energy dissipation from the primary structure by different magnetic NVAs is compared by wavelet transform analysis. The results show that due to the largest oscillations of crossing outmost wells, the optimized 3RMNVA and 3AMNVA are the preferred configurations for magnetic NVA under different excitation levels. Meanwhile, through the verification and comparison with reported designs, the effectiveness of the optimization method and the optimized NVAs in this paper are confirmed. This work provides the approach and guidelines to design the effective NVA to suppress transient vibrations.
Monitoring prestress in plates by sideband peak count-index (SPC-I) and nonlinear higher harmonics techniques
Authors: Wang Meng , Pau Annamaria , Zhang Guangdong , Kundu Tribikram 
Published: July 2023

AbstractPropagating guided waves in a homogeneous, isotropic, prestressed, hyperelastic plate show nonlinear characteristics that depend on the state of initial prestress. These nonlinear phenomena include higher harmonic generation, occurring when Lamb wave modes of different frequencies ($$\omega _a$$

ω
a

and $$\omega _b$$

ω
b

) are allowed to mix within the material generating secondary waves at frequencies $$2\omega _a,2\omega _b\, \text {and}\,\omega _a\pm \omega _b$$

2

ω
a

,
2

ω
b

and

ω
a

±

ω
b

. Further, if prescribed internal-resonance conditions are satisfied, the amplitude of secondary waves increases in space, providing a response quantity which is dependent on prestress and easy to be observed. Using the finite element method, in this paper we investigate the time and space evolution of higher harmonics arising in one-way wave mixing. The influence of prestress on the response is elucidated, observing the nonlinear parameter $$\beta $$
β
. It is further shown that the nonlinear ultrasonic technique called sideband peak count-index (SPC-I) can provide an effective monitoring tool for prestress.
Are Si–C bonds formed in the environment and/or in technical microbiological systems?
Authors: Rücker Christoph , Winkelmann Magnus , Kümmerer Klaus 
Published: July 2023

AbstractOrganosiloxanes are industrially produced worldwide in millions of tons per annum and are widely used by industry, professionals, and consumers. Some of these compounds are PBT (persistent, biaccumulative and toxic) or vPvB (very persistent and very bioaccumulative). If organosiloxanes react at all in the environment, Si–O bonds are hydrolyzed or Si–C bonds are oxidatively cleaved, to result finally in silica and carbon dioxide. In strong contrast and very unexpectedly, recently formation of new Si–CH3bonds from siloxanes and methane by the action of microorganisms under mild ambient conditions was proposed (in landfills or digesters) and even reported (in a biotrickling filter, 30 °C). This is very surprising in view of the harsh conditions required in industrial Si–CH3synthesis. Here, we scrutinized the pertinent papers, with the result that evidence put forward for Si–C bond formation from siloxanes and methane in technical microbiological systems is invalid, suggesting such reactions will not occur in the environment where they are even less favored by conditions. The claim of such reactions followed from erroneous calculations and misinterpretation of experimental results. We propose an alternative explanation of the experimental observations, i.e., the putative observation of such reactions was presumably due to confusion of two compounds, hexamethyldisiloxane and dimethylsilanediol, that elute at similar retention times from standard GC columns.
Medical Management of Right Ventricular Dysfunction in Pulmonary Arterial Hypertension
Authors: Caputo Annalisa , Papa Silvia , Manzi Giovanna , Laviola Domenico , Recchioni Tommaso , Severino Paolo , Lavalle Carlo , Maestrini Viviana , Mancone Massimo , Badagliacca Roberto , Vizza Carmine Dario 
Published: July 2023

Abstract
Purpose of Review
The purpose of this review is to overview the most relevant and recent knowledge regarding medical management in pulmonary arterial hypertension (PAH).

Recent Findings
Evidence has shown that PAH patients’ quality of life and prognosis depend on the capability of the RV to adapt to increased afterload and to fully recover in response to substantially reduced pulmonary vascular resistance obtained with medical therapy.
Data from recent clinical studies show that more aggressive treatment strategies, especially in higher risk categories, determine larger afterload reductions, consequentially increasing the probability of achieving right heart reverse remodeling, therefore improving the patients’ survival and quality of life.
Remarkable progress has been observed over the past decades in the medical treatment of PAH, related to the development of drugs that target multiple biological pathways, strategies for earlier and more aggressive treatment interventions.

Summary
New hopes for treatment of patients who are unable to achieve low-risk status have been derived from the phase 2 trial PULSAR and the phase 3 trial STELLAR, which show improvement in the hemodynamic status of patients treated with sotatercept on top of background therapy. Promising results are expected from several ongoing clinical trials targeting new pathways involved in the pathophysiology of PAH.
Valorization of biorefinery residues for sustainable fertilizer production: a comprehensive review
Authors: Chojnacka Katarzyna 
Published: July 2023

AbstractThe management of biowaste and agricultural solid waste is gaining attention due to rising landfill disposal costs and the need for locally available agricultural feedstocks. The biorefinery concept aims to achieve zero waste through valorizing residues as fertilizers. Despite containing NPK macronutrients, residues may not promote plant growth due to limited nutrient availability and phytotoxic compounds. The production of valuable organic, mineral-organic, or mineral fertilizers with confirmed agronomic properties as marketable biorefinery products remains understudied. This comprehensive review broadens our understanding of fertilizer production in biorefineries, which complements the energy (thermal, biogas, biodiesel) and chemical compounds (e.g., succinic acid, propanediol, protein concentrates) that are also generated within biorefineries. It is among the first reviews to investigate the importance of valorizing biorefinery residues as fertilizers, emphasizing methods leading to commercial products and the rationale behind this process. The findings confirm that directly applying unprocessed residues to the soil does not fully exploit their value as by-products. This study contributes to the practical analysis of barriers (legal, chemical, biological, technological) and opportunities (rising prices and reduced global availability of mineral fertilizers) related to fertilizer production in the biorefining process.
Revisiting Edward D. Cope’s “The Relation of Animal Motion to Animal Evolution” (1878)
Authors: McGhee George R. 
Published: July 2023

AbstractIn 1878 evolutionary theoretician Edward D. Cope published an eight-page paper filled with prescient ideas that clearly anticipated theoretical evolutionary topics that are actively being debated some 145 years later. An examination of these ideas and their modern counterparts is the primary objective of this essay. A proposal is also made to provide an answer to Cope’s Puzzle concerning the sequences of events involved in the evolution of adaptive animal structures. This article revisits Cope’s “The Relation of Animal Motion to Animal Evolution” (published in The American Naturalist, volume 12, number 1, January 1878, pp. 40–48) for Biological Theory’s “Classics in Biological Theory” collection; Cope’s original paper is available as supplementary material in the online version of this article.
In Situ Tracking of Break-up, Resuspension, and Transport of Reactive Particle Structures in a Single Wall-Flow Filter Channel
Authors: Thieringer Julia R. D. , Werling Heike , Meyer Jörg , Dittler Achim 
Published: July 2023

AbstractParticulate filters are used as a standard component in the exhaust gas aftertreatment of vehicles. The reactive (soot) and inert (ash) particles generated during engine operation are deposited in wall-flow filter. The resulting particle layer increases the differential pressure of the filter, which is why it is regenerated regularly. During regeneration of the filter, the reactive particles oxidize, and the inert particles remain in the filter. The oxidation of the soot particles results in a layer break-up, and the resuspension of particle structures can occur. The layer break-up over the entire length of an inlet channel and the resuspension of particle structures have not yet been observed, which is why the fundamental processes in a particulate filter have not yet been fully clarified. In these investigations, the regeneration of a single wall-flow filter channel is observed in situ with high temporal and spatial resolution. For this purpose, the filter is loaded with soot particles and regenerated subsequently. The regeneration of the filter is analyzed in relation to the process parameters of temperature, layer thickness, and flow velocity. Before the visual layer break-up, the pressure drop decreases and declines to a constant value before resuspension of particle structures are detected. As the temperature is increased, the regeneration time is reduced. With a thicker particle layer, the particle structures formed during layer break-up become larger, the location of resuspension shifts to the posterior channel region, and the number of resuspensions increases. A higher flow velocity causes more particle structures to be resuspended and transported to the channel end.
Calculation Model for the Steady-State Vibration Amplitude of a New Type of Cascaded Composite Structure-Based Ultrasonic Transducer
Authors: Zhang Hongjie , Gao Xinyue , Liu Xiaochen , Wu Junqiang 
Published: July 2023

AbstractThe steady-state vibration amplitude is an important performance indicator of high-frequency ultrasonic transducers for ultrasonically assisted manipulating, machining, and manufacturing. This work aimed to develop a calculation model for the steady-state vibration amplitude of a new type of dual-branch cascaded composite structure-based ultrasonic transducer that can be used in the packaging of microelectronic chips. First, the steady-state vibration amplitude of the piezoelectric vibrator of the transducer was derived from the piezoelectric equation. Second, the vibration transfer matrices of the tapered ultrasonic horns were obtained by combining the vibration equation, the continuous condition of the displacement, and the equilibrium condition of the force. Calculation models for the steady-state vibration amplitude of the two working ends of the transducer were then developed. A series of exciting trials were carried out to test the performance of the models. Comparison between the calculated and measured results for steady-state vibration amplitude showed that the maximum deviation was 0.0221 μm, the minimum deviation was 0.0013 μm, the average deviation was 0.0097 μm, and the standard deviation was 0.0046 μm. These values indicated good calculation accuracy, laying a good foundation for the practical application of the proposed transducer.
Analysis of number, size and spatial distribution of rifle bullet-derived lead fragments in hunted roe deer using computed tomography
Authors: Haase Annina , Sen Miriam , Gremse Carl , Mader Anneluise , Korkmaz Birsen , Jungnickel Harald , Hildebrandt Thomas B. , Fritsch Guido , Numata Jorge , Moenning Jan-Louis , Steinhoff-Wagner Julia , Lahrssen-Wiederholt Monika , Pieper Robert 
Published: July 2023

AbstractThe use of lead-based rifle bullets in hunting poses a risk to human and animal health when bullet fragments remain in the game meat. The objective of this study was to assess, for the first time, the number, size and spatial distribution of bullet fragments in game animals collectively and in three dimensions. Four roe deer (Capreolus capreolus) hunted with lead bullets were radiographed using computed tomography (CT) at each step of meat processing from animal bodies to edible parts. The animal bodies contained 43–199 fragments with a mean volume of 3.71 ± 5.49 mm3 and a mean distance of 6.5 ± 4.6 cm perpendicular to the wound channel. About 40% of the fragments were in the lower size range of < 1.00 mm3. Individual fragments were located up to 22.2 cm from the wound channel and were located in the edible parts (ribs, n = 2; haunch, n = 1; shoulder, n = 3) with up to 0.29 g (0.16 ± 0.15 g, mean ± SD) of estimated bullet fragment mass (BFM) deposited in the edible parts of the roe deer. Tissues in a radius of at least 16 cm around the wound channel should have been discarded in order to remove 95% of the BFM from the investigated roe deer. Additionally, around 85.1% of the initial bullet mass corresponding to 9.948 ± 1.040 g BFM were estimated to be introduced into the environment. This study highlights the challenges of ensuring sufficient removal of lead-based rifle bullet fragments in game meat processing for either human consumption purposes or for use as pet food.
Is there anybody out there? Can individual loneliness, need for closure, and religiosity predict the belief in extraterrestrial life and intelligence?
Authors: Döbler Niklas Alexander , El Amri Yassin , Carbon Claus-Christian 
Published: July 2023

AbstractThinking about the universe also includes thinking about hypothetical extraterrestrial intelligence. Two key questions arise: Why are we thinking aboutthemin the first place? And why are we anthropomorphizingthem? One possible explanation may be that the belief in extraterrestrials results from a subjective feeling of loneliness or the need for closure. Results of an online questionnaire (N = 130) did not reveal a confident and consistent correlation between personal feelings of aloneness or need for closure and belief in extraterrestrial life or intelligence. The same was true for the anthropomorphic representation of extraterrestrial intelligence. The belief in extraterrestrial life was negatively linked to frequent religious activity, and to a lesser and more uncertain extent, to the belief in extraterrestrial intelligence. As evidenced by their parameter estimates, participants demonstrated an intuitive grasp of the probabilities inherent in the Drake equation. However, there was significant variability in the solutions provided. When asked to describe hypothetical extraterrestrials, participants mainly assessed them in terms connoted with physical appearance, neutral to humans, and partially influenced by anthropomorphism. Given the severe limitations, we conservatively conclude that individual loneliness is indeed individual and does not break the final frontier, that is, space.
Single-nucleus transcriptomic atlas of glial cells in human dorsal root ganglia
Authors: Zhang Donghang , Wei Yiyong , Chen Yali , Chen Hongjun , Li Jin , Yang Yaoxin , Zhou Cheng 
Published: July 2023

Abstract
Purpose
Glial cells play a crucial role in regulating physiological and pathological functions, such as sensation, infections, acute injuries, and chronic neurodegenerative disorders. Despite the recent understanding of glial subtypes and functional heterogeneity in central nervous system via single-cell/nucleus RNA sequencing, the transcriptomic profiles of glial cells in the adult human dorsal root ganglia (DRG) have not yet been characterized at single-cell resolution.

Methods
We used high-throughput single-nucleus RNA sequencing to map the cellular and molecular heterogeneity of satellite glial cells (SGCs) and Schwann cells (SCs) in the human DRG, and further compared these human findings with those from mice. The expression profiles of classical marker genes of peripheral somatosensory system in glial cells were examined in human and mouse DRG. Additionally, the functional properties of the enriched genes in glial cells and their subtypes were also explored by Gene Ontology (GO) term analysis.

Results
Human DRG cells were initially classified into 11 clusters based on their distinct transcriptional characteristics. SGCs and SCs were identified through their representative marker genes. SGCs were further classified into six subclusters, while SCs were classified into seven subclusters. The comparison with mouse transcriptomic profiles revealed an overall similarity between the two species, while simultaneously highlighting some degree of heterogeneity in specific genes.

Conclusions
This atlas comprehensively profiled glial cell heterogeneity and provides a powerful resource for investigating the cellular basis of physiological and pathological conditions associated with DRG glial cells.

Graphical Abstract
Time to act: A rubric-based approach for institutionalizing justice, equity, diversity, and inclusion
Authors: Norman Marie K. , Radomski Thomas R. , Proulx Chelsea N. , Rubio Doris M. , Alston Tasha L. , Mayowski Colleen A. 
Published: July 2023

Abstract
Attacks on minoritized communities and increasing awareness of the societal causes of health disparities have combined to highlight deep systemic inequities. In response, academic health centers have prioritized justice, equity, diversity, and inclusion (JEDI) in their strategic goals. To have a sustained impact, JEDI efforts cannot be siloed; rather, they must be woven into the fabric of our work and systematically assessed to promote meaningful outcomes and accountability. To this end, the University of Pittsburgh’s Institute for Clinical Research Education assembled a task force to create and apply a rubric to identify short and long-term JEDI goals, assess the current state of JEDI at our Institute, and make recommendations for immediate action. To ensure deep buy-in, we gathered input from diverse members of our academic community, who served on targeted subcommittees. We then applied a three-step process to ensure rapid forward progress. We emerged with concrete actions for priority focus and a plan for ongoing assessment of JEDI institutionalization. We believe our process and rubric offer a scalable and adaptable model for other institutions and departments to follow as we work together across academic medical institutions to put our justice, equity, diversity, and inclusion goals into meaningful action.
A switching Gaussian process latent force model for the identification of mechanical systems with a discontinuous nonlinearity
Authors: Marino Luca , Cicirello Alice 
Published: July 2023

Abstract
An approach for the identification of discontinuous and nonsmooth nonlinear forces, as those generated by frictional contacts, in mechanical systems that can be approximated by a single-degree-of-freedom model is presented. To handle the sharp variations and multiple motion regimes introduced by these nonlinearities in the dynamic response, the partially known physics-based model and noisy measurements of the system’s response to a known input force are combined within a switching Gaussian process latent force model (GPLFM). In this grey-box framework, multiple Gaussian processes are used to model the unknown nonlinear force across different motion regimes and a resetting model enables the generation of discontinuities. The states of the system, nonlinear force, and regime transitions are inferred by using filtering and smoothing techniques for switching linear dynamical systems. The proposed switching GPLFM is applied to a simulated dry friction oscillator and an experimental setup consisting of a single-storey frame with a brass-to-steel contact. Excellent results are obtained in terms of the identified nonlinear and discontinuous friction force for varying: (i) normal load amplitudes in the contact; (ii) measurement noise levels, and (iii) number of samples in the datasets. Moreover, the identified states, friction force, and sequence of motion regimes are used for evaluating: (1) uncertain system parameters; (2) the friction force–velocity relationship, and (3) the static friction force. The correct identification of the discontinuous nonlinear force and the quantification of any remaining uncertainty in its prediction enable the implementation of an accurate forward model able to predict the system’s response to different input forces.