bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined treatment of high and very high risk prostate cancer: results of neoadjuvant treatment
Authors: Troyanov A. V. , Biryukov V. A. , Zaborsky I. V. , Chaykov V. S. , Dementev I. O. , Shchukina E. O. , Karyakin O. B. 
Published: June 2023

Purpose of the study. Assessment of safety and short‑term effectiveness of high and very high‑risk prostate cancer neoadjuvant chemo‑ hormonal treatment without distant metastases.Patients and methods. Combined hormone chemo‑ radiation treatment of 33 patients with prostate cancer of high and very high risk of progression without distant metastases was performed. Metastases to regional lymph nodes were found in 9 patients according to the examination data (MRI, MSCT), no metastases were detected in 24 patients. All patients underwent combined chemohormonal therapy in the amount of 4 courses of docetaxel intravenously at a dose of 75 mg/m2 every 3 weeks as the first stage of treatment. in combination with androgen deprivation therapy with agonists or antagonists of GnRH before performing radical radiation therapy (combined or remote). All patients underwent neoadjuvant hormone therapy: 16 patients – with the use of GnRH antagonists (Degarelix), 17 – with the use of GnRH agonists (Gozerelin/Leuprorelin/Triptorelin). The toxicity of the presented treatment regimen and its immediate effectiveness – the effect on the level of prostate‑s pecific antigen (PSA), prostate volume, and the quality of urination – were evaluated.Results. Treatment regimen was highly effective concerning PSA decrease (from initial median level 79,67 ng/ml to 1,45 ng/ml after neoadjuvant treatment), all subjects responded well, no non‑responders observed. Median prostate volume decreased from 44 cm3 to 25 cm3 after treatment, which guaranteed availability and safety of further radical radiation treatment. Urinary function was restored in all subject with initial urinary retention.Conclusion. Neoadjuvant chemo‑h ormonal treatment was highly effective in PSA level, prostate volume decrease and functional results improvement which secured further radical radiation treatment in one of its types. Toxicity was acceptable, adverse events did not exceed grade II in most cases and did not lead to treatment discontinuation in any cases, while quality of life remained high enough.
Evolution of drug therapy in patients with resectable gastric and esophageal‑gastric junction cancer
Authors: Sedova M. V. , Batov M. A. , Tretyak V. S. , Kolomeytseva A. A. , Khomyakov V. M. , Volchenko N. N. , Fedenko A. A. , Kaprin A. D. 
Published: June 2023

Gastric cancer (GC) is the fifth most common malignant neoplasm in the world among all malignant tumors. Currently, the “gold” standard of treatment for patients with non‑metastatic cancer of the stomach and esophageal–gastric junction is surgical treatment, which is complemented by perioperative chemotherapy according to the FLOT scheme, which includes four courses of therapy before surgery and four after. However, according to statistics, less than half of patients complete all adjuvant courses of FLOT chemotherapy due to the high toxicity of the regimen and a decrease in the functional status of patients in the postoperative period. In this regard, studies are being conducted to study the tolerability of total neoadjuvant chemotherapy, when all courses are held at the preoperative stage in order to carry out all stages of treatment in full. International studies have shown the results of the use of targeted (ramucirumab, trastuzumab, pertuzumab), immune drugs (pembrolizumab, nivolumab, ipilimumab), S‑1 in combination with chemotherapy as part of the combined treatment of gastric and esophageal‑ gastric junction cancer. The emergence of new therapeutic agents previously studied in metastatic GC may change approaches to the treatment of localized and locally advanced GC.The review presents the features of perioperative therapy regimens in patients with resectable gastric and esophageal‑ gastric junction cancer in order to reduce the frequency of local and long‑term relapses and improve further prognosis.
The influence of the genotype and respiratory tract microflora on lung function and nutritional status in adult cystic fibrosis patients in long-term follow-up
Authors: Titova O. N. , Makhmutova V. R. , Gembitskaya T. E. , Chermensky A. G. , Stepanenko T. A. , Shklyarevich N. A. 
Published: June 2023

In recent years, an increase in the number of patients with chronic infection with nonfermenting gram-negative bacteria (NFGNB) in adult patients with cystic fibrosis (CF) has increased. The genotype and phenotype characteristics, NFGNB structure, changes in sensitivity and the development of antibiotic resistance in adult patients have not been adequately studied.Aim. To determine the impact of genotype severity and Achromobacter xylosoxidans sensitivity to carbapenems on the functional and nutritional status of adult cystic fibrosis patients over a period 2016 – 2021.Materials. Retrospective analysis of genotypic and microbiological data from 54 adult CF patients and their effects on FEV1 and BMI over a period 2016 – 2021. Sputum cultures were confirmed by MALDI-TOF mass spectrometer. Depending on the severity of the mutation, the patients were divided into 2 groups: group 1 (“severe” genotype) – patients who had 2 mutations of class I – III; group 2 (“soft” genotype) – at least 1 class IV – VI mutation.Results. The group of patients with “mild” mutations had a higher BMI (kg / m2) than the group with severe mutations for a longer period of follow-up from 2018 – 2021 than in the group with severe mutations: BMI (2016) – 21.14 ± 3.55 / 19.28 ± 3.13 (p = 0.163); BMI (2017) – 21.27 ± 3.43 / 18.31 ± 2.05 (p = 0.123); BMI (2018) – 21.17 ± 4.00 / 18.80 ± 2.12 (p = 0.025); BMI (2019) – 21.01 ± 4.20 / 18.55 ± 2.53 (p = 0.049); BMI (2020) – 20.94 ± 4.12 / 18.41 ± 2.15 (p = 0.050). Age at diagnosis was 20.36 ± 2.18 years for “mild” genotypes and was higher (p = 0.042) than for “severe” genotypes (6.27 ± 1.53 years). All 7 patients who died (100%) were in the “severe” genotype group (23.3%). Functional status assessment showed no differences in FEV1 over 6 years between the “severe” and “mild” genotype groups: FEV1 (2016) – p = 0.51; FEV1 (2017) – p = 0.39; FEV1 (2018) – p = 0.51; FEV1 (2019) – p = 0.35; FEV1 (2020) – p = 0.48. Nonfermenting Gram-negative bacteria accounted for 49.9% of the isolated microorganisms. The group of carbapenem-resistant Achromobacter xylosoxidans lost the FEV1 level faster every year for 6 years (p < 0.05) compared to the group of the sensitive variant.Conclusion. In general, patients with the “mild” genotype have higher nutritional status and do not differ from patients with the “severe” genotype in terms of FEV1. The survival rate of patients with the “mild” genotype patients survival rate is higher, despite the later diagnosis and start of treatment. Development of carbаpenem resistance in Achromobacter xylosoxidans is associated with an unfavorable prognosis of the functional status decline.
Efficacy of benralizumab in severe eosinophilic asthma: an interim analysis of a real clinical practice prospective study BEST in Russia
Authors: Fomina D. S. , Ignatova G. L. , Kabanova T. G. , Kameleva A. A. , Kozyreva L. S. , Kosyakova N. I. , Kudelya L. M. , Kuzubova N. A. , Leshсhenko I. V. , Mukhina O. A. , Shulzhenko L. V. 
Published: June 2023

Systematizing clinical experience in the use of biological treatments in patients with severe bronchial asthma in real world settings with assessment of clinical outcomes and quality of life level is of great interest and value in practical pulmonology.The aim of the BEST study (Real World Evidence of Benralizumab in Eosinophilic Severe AsThma in Russia) was to evaluate effectiveness of benralizumab by control and quality of life associated with respiratory status in patients with eosinophilic phenotype of severe asthma in real clinical practice in Russia.Results. The results obtained through 16 weeks of benralizumab therapy in patients with severe eosinophilic asthma (SEA) were analyzed. All 59 enrolled patients showed significant improvement in the asthma control questionnaire (ACQ-5) score, the quality of life associated with respiratory status according to the St. George Respiratory Questionnaire (SGRQ), and subjective assessments of the well-being of patients and the disease severity (PGIC and PGIS). Treatment with benralizumab contributed to a reduction in the oral glucocorticosteroids intake throughout the study period.Conclusion. In real clinical practice, treatment with benralizumab results in significant improvement in disease control and the quality of life in patients with severe eosinophilic asthma and is characterized by a favorable safety profile.
Modified matrix minima method for subset constrained transportation problem and its performance evaluation with respect to the optimal solution by mathematical model
Authors: Prajapati Raju , Pal Jayantika , Dubey Om Prakash 
Published: June 2023

Purpose of the study: The transportation problem has a huge application in logistics. Therefore, dealing a transportation problem with permissible constraints is always an interesting area. In the present paper, we have tried a version of transportation problem which is constrained in nature. We have explored strategies for dealing the subset constrained transportation problem.
Methodology: An updated version of matrix minima method is proposed in this paper. This version is used for subset constrained transportation problem only. We have also applied the mathematical model for solving the same subset constrained transportation problem.
Main Findings: The mathematical model gives an optimal solution of the constrained transportation problem with the help of software. It is found that the proposed updated matrix minima method does not guarantee the optimality. However, we use the matrix minima approach for having an idea of the closer feasible solution. It is found that the mathematical model is always a superior way to find an optimal solution.
Applications of this study: The study has a huge application in logistics.
Novelty/Originality of this study: An updated version of matrix minima method is proposed. The method is applied on constrained transportation problem and the results are compared with the optimal solution.
Herramientas jurídicas y administrativas disponibles para evitar la caduci¬dad de la acción de cobro y la prescripción de las obligaciones del IPU. El caso del municipio de Pereira, Colombia
Authors: López Mejía Manuela 
Published: June 2023

Las entidades territoriales, en el ejercicio de la función administradora de recursos pú­blicos, para garantizar su liquidez, así como la sostenibilidad económica y fiscal de la entidad, deben realizar la gestión de cobro mediante la implementación del proceso administrativo de cobro coactivo con el fin de hacer efectivas las obligaciones insolu­tas por concepto de impuestos territoriales y, especialmente, de impuesto predial; no obstante, existen varios factores que influyen negativamente en el logro del objetivo de obtener ingresos de fuente endógena como son los impuestos, teniendo como conse­cuencia la caducidad de la acción de cobro y la prescripción de las obligaciones.
Como solución a lo anterior, existen mecanismos jurídicos y administrativos aplicables a las diferentes etapas del proceso de cobro coactivo que evitan el acaecimiento de los fenómenos de prescripción y caducidad, siendo necesario identificar cuáles producen un impacto positivo en el recaudo del impuesto predial a partir del caso del municipio de Pereira ejecutadas de 2016 a 2020.
ВПЛИВ ОЩАДЛИВОГО ВИРОБНИЦТВА НА ЕКОНОМІЧНУ ПОВЕДІНКУ ПІДПРИЄМСТВ В СУЧАСНИХ УМОВАХ ГОСПОДАРЮВАННЯ
Authors: Каличева Н. Є. , Чорнобровка І. В. 
Published: June 2023

Формування економічної поведінки підприємства має закладатися в технологію процесу виробництва та ґрунтуватися на підходах підвищення ефективності його роботи в сучасних умовах господарювання. В статті зазначено, що ощадливе виробництво є одним із найбільш оптимальних та продуктивних інструментів для забезпечення стабільного розвитку підприємства через постійне зниження витрат у виробничому та управлінському процесах. Окреслено основні підходи щодо розуміння впливу концепції ощадливого виробництва на економічну поведінку підприємства.Визначено, що забезпечення ефективного розвитку підприємства є досить складним механізмом, в основу якого покладено орієнтацію на запити споживачів, які виступають повноцінними учасниками бізнес-процесів. Це призводить до зміни підходів щодо формування економічної поведінки підприємства та його конкурентоспроможності.
ЦИФРОВА ТРАНСФОРМАЦІЯ ПІДПРИЄМСТВ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ В УМОВАХ РОЗБУДОВИ ГЛОБАЛЬНОГО ЦИФРОВОГО ТРАНСПОРТНО-ЛОГІСТИЧНОГО ПРОСТОРУ
Authors: Обруч Г. В. 
Published: June 2023

У статті досліджено тенденції цифровізації світових залізниць і виявлено розширення меж впливу цифрових технологій на діяльність суб’єктів даної сфери господарювання. Зазначено, що в умовах активізації процесів розбудови глобального цифрового транспортно-логістичного простору вітчизняним підприємствам залізничного транспорту слід зосередити увагу на цифровій трансформації і модернізації їх діяльності, що дозволить покращити експлуатаційні характеристики роботи залізничного транспорту і якісно удосконалити бізнес-процеси на підприємствах галузі. Розкрито глобальні передумови цифровізації і основні напрями впровадження цифрових інновацій на підприємствах залізничного транспорту.Визначено основні функції цифрового інструментарію розвитку підприємств залізничного транспорту і умови його успішного застосування. Доведено, що критерієм ефективного застосування цифрових інструментів у залізничній галузі слід розглядати цифрову когерентність, яка передбачає інтеграцію доповненого реального та віртуального середовища розвитку підприємств залізничного транспорту.Розкрито ключові цифрові інструменти формування доповненого реального та віртуального середовища розвитку підприємств залізничного транспорту.
Pendekatan Metode Kolokasi untuk Text Processing Ulasan Aplikasi Android Surveilans Penyebaran Covid-19 di Indonesia
Authors: Asyhari Moch Yusuf , Juwari Juwari , Hapsari Estuning Dewi , Yulianto Slamet 
Published: June 2023

Abstrak Ã¢â‚¬â€œ Aplikasi surveilans penyebaran covid-19 di Indonesia telah diberlakukan secara masif sejak surat edaran mendagri tahun 2021 dengan nama Aplikasi Peduli Lindungi. Pencarian sumber masalah paling umum yang menyebabkan aplikasi peduli lindungi mendapatkan penilaian bintang satu oleh penggunanya dapat dilakukan dengan membaca ulasan. Metode yang digunakan meliputi data scraping untuk mengumpulkan data, attribute selection untuk memilih data yang digunakan, text preprocessing untuk membersihkan dan mempersiapkan data, text processing meliputi data sorting, word frequency, dan collocation, serta visualization untuk merepresentasikan hasilnya. Ditemukan 82.265 ulasan dengan bintang satu di google play store. Terdiri dari 73.919 ulasan yang dilengkapi dengan alasan dan sisanya hanya memberikan penilaian bintang satu saja. Data sorting berdasarkan versi aplikasi menunjukkan bahwa tidak semua pengguna menggunakan aplikasi dengan versi yang terbaru. Data sorting berdasarkan thumbsUp menunjukkan bahwa masalah sertifikat, versi aplikasi dengan perangkat lama, serta user experience di formulir tanggal lahir yang paling banyak dikeluhkan oleh penggunanya. Kata-kata yang paling sering muncul di ulasan dengan pembatasan bintang satu diantaranya adalah kata Ã¢â‚¬Å“tidakÃ¢â‚¬Â, Ã¢â‚¬Å“aplikasiÃ¢â‚¬Â, Ã¢â‚¬Å“bisaÃ¢â‚¬Â, Ã¢â‚¬Å“sudahÃ¢â‚¬Â, dan Ã¢â‚¬Å“vaksinÃ¢â‚¬Â. Kumpulan kata tersebut menjadi lebih bermakna dengan pendekatan metode kolokasi yang ditemukan, seperti Ã¢â‚¬Å“Sudah vaksin, tidak ada, sertifikat vaksinÃ¢â‚¬Â. Hasil temuan tersebut lebih mudah dianalisis dengan visualization menggunakan word cloud collocation.
Kata Kunci: android; data scraping; kolokasi; surveilans; text processing; visualization; word cloud
Evaluasi Program Garda Ampuh di Kecamatan Rogojampi Kabupaten Banyuwangi
Authors: Dwireswari Alya Sandia , Anwar Anwar , Sutomo Sutomo 
Published: June 2023

Program Garda Ampuh dibentuk oleh Pemerintah Kabupaten Banyuwangi untuk mengentaskan anak putus sekolah atau rentan putus sekolah. Penelitian ini bertujuan mendeskripsikan evaluasi dari pelaksanaan program Garda Ampuh di Kecamatan Rogojampi. Evaluasi mengacu pada konsep milik William N. Dunn dengan menggunakan enam kriteria evaluasi. Penelitian ini menggunakan pendekatan kualitatif desktiprif. Data yang digunakan berupa data kualitatif yang terdiri dari data primer dan sekunder yang dikumpulkan melalui wawancara dan dokumentasi. Teknik uji keabsahan data menggunakan teknik triangulasi sumber dan teknik analisis data menggunakan model milik Miles, Huberman, dan Saldana. Hasil penelitian menunjukkan bahwa berdasarkan enam kriteria evaluasi, program Garda Ampuh telah memberikan bantuan kepada siswa dengan kondisi ekonomi tidak mampu meskipun terdapat beberapa kriteria yang belum terpenuhi yaitu efektivitas, perataan, responsivitas, dan ketepatan karena terdapat siswa yang usulannya tidak diterima, kurang terbentuknya koordinasi dan komunikasi antara Dinas Pendidikan, Korwilkersatdik, dan sekolah, tidak ada pengawasan penggunaan dana, dan belum tercakupnya semua sasaran dari program. Program Garda Ampuh menghasilkan dampak positif terutama yang berkaitan dengan timbulnya rasa percaya diri siswa dan perubahan pola pikir orang tua yang anaknya harus membantu ekonomi keluarga.
Kata kunci: Evaluasi; Garda Ampuh
Kinerja Implementasi Program Pendaftaran Tanah Sistematis Lengkap di Desa Soddara Kecamatan Pasongsongan Kabupaten Sumenep
Authors: Kharisma Dinda Alfania , Makmur M. Hadi , Pamungkas Tree Setiawan 
Published: June 2023

This study aims to describe the implementation’s performance of Complete Systematic Land Registration (PTSL) program in Soddara Village Pasongsongan Subdistrict Sumenep Regency. The basis for this research is the problem of the land area owned by the community, which is not yet legally documented and raises land disputes. The Village Government is trying to solve the problem by proposing the implementation of the Comprehensive Systematic Land Registration (PTSL) program to the Sumenep Regency Land Office. The approach and research method used is qualitative with the type of data consisting of primary data and secondary data obtained through interview, observation, and documentation techniques. The validity of data was tested using the data triangulation technique. Analysis of the data using the interactive model of Miles, Huberman, and Saldana. The result showed that out of eight implementation’s performance described by Ripley, only accountability aspects were not found in this study.
Keywords: Implementation; PTSL
TECHNOLOGY OF SHAPING AND ANALYSIS OF CONTACT INTERACTION OF MACHINE PARTS
Authors: Tkachuk Mykola M. , Grabovskiy Andrey , Pinchuk Natalija , Tretyak Vladeslav , Domina Natalia , Voloshyna Iryna 
Published: June 2023

Elements of transmissions and other machine parts in many cases have a complex shape of contacting surfaces. On the one hand, their form is determined by kinematic conditions associated with the transfer of motion between structural elements. On the other hand, the design geometry is limited by strength criteria. Keeping the shape of the contacting surfaces as close to each other as possible generally facilitates the reduction of stress levels. As a result, there is a combined problem of synthesis of geometric form and analysis of kinematic interaction of complex-profile bodies. A general approach that implements objective-driven variation of the shape of the contacting bodies has been developed for this purpose. At the same time, the varied geometric shape is approximated by prismatic finite elements. A topologically regular mesh of finite elements is formed. As a result, it is possible to parametrize the geometrical model of the researched objects, as well as to perform automated multivariate calculations. Accordingly, this array of information becomes the basis for establishing patterns of influence of various factors on the stress-deformed state of contacting bodies. It also makes it possible to formulate recommendations regarding the substantiation of advanced technological solutions of machine parts that transmit mechanical loads through moving contact. Therefore, both the functional properties of these structural components and limitations, for example, in terms of strength and durability, are provided. A method of geometric shape synthesis integrated with generalized parametric modeling was developed, as well as an approach to geometric synthesis of the shape of kinematically generated surfaces. This makes it possible to calculate the distribution of contact pressure and the stress-strain state of contacting complex bodies. For the formation of high-quality finite-element models, a method based on the creation of topologically regular mesh in the curvilinear coordinates of the working surfaces is proposed. The application and effectiveness of the developed methods and models are illustrated on the example of two-parameter transmissions. Correspondence of the results obtained by different methods was confirmed.
Keywords: complex-profile bodies; contact interaction; stress-strained state; kinematic interaction
Potensi Cadangan Karbon pada Pohon dengan Penginderaan jauh di KPHP Kabupaten Sorong
Authors: Farida Anif Farida , Ponisri Ponisri  
Published: June 2023

Tujuan dari penelitian ini adalah adalah untuk mengetahui estimasi cadangan karbon berdasarkan nilai NDVI di hutan produksi KPHP Kabupaten Sorong. Metode yang digunakan yaitu analisis NDVI untuk mendapatkan estimasi cadangan karbon berdasarkan data lapangan (allometrik) pada tingkat pohon. Hasil penelitian menunjukkan bahwa kerapatan vegetasi yang ada di hutan produksi KPHP didominasi oleh kelas tinggi (57,40 %)disusul berturut-turut kelas sedang (40,40 %) dan rendah (2,06 %). Persamaan regresi cadangan karbon yang diperoleh yaitu y = 2,071+4,351*NDVI. Besarnya cadangan karbon dengan NDVI di hutan poduksi KPHP Unit II Sorong berkisar dari 1,667 ton/ha-5,113 ton/ha.