bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterações em marcadores neurometabólitos após tratamento manipulativo osteopático em indivíduos com lombalgia crônica inespecífica: revisão sistemática de ensaios clínicos randomizados
Authors: Burin Tânia , Mansur Guedes Janesca 
Published: June 2023

Acredita-se que as dores crônicas são percebidas pelo indivíduo devido a mudanças na função do sistema nervoso central, sendo os metabólitos cerebrais uma das alterações observáveis. O objetivo deste estudo foi determinar os efeitos do tratamento manipulativo osteopático sobre neurometabólitos, em indivíduos com lombalgia crônica. A pesquisa foi realizada em 4 bancos de dados eletrônicos entre 1985 a 2021 e 2 estudos (45 participantes) que atenderam aos critérios de inclusão foram incluídos na análise. Dois autores extraíram e avaliaram independentemente o risco de viés nos estudos incluídos. A qualidade metodológica foi avaliada através do instrumento chamado de RoB 2.0 (de Risk of Bias). Houve evidência de que o tratamento manipulativo osteopático aumenta as concentrações de β Endorfina e N-palmitoiletanolamida, N-acetil aspartato, acetilcolina, glutamato e glutamina, bem como a diminuição nos níveis de anandamida. A revisão atual constatou que a abordagem osteopática pode aumentar as concentrações de metabólitos em regiões específicas do cérebro e plasma sanguíneo, auxiliando no alívio da dor lombar crônica. No entanto, os estudos ainda são incipientes, necessitando de maior evidência científica na área.
Vladimir G. Shubin. Is the Wait Over? (To the Results of the 55th National Conference of ANC)
Authors: Shubin Vladimir G. 
Published: June 2023

This article is a continuation of the article “South Africa: Hard times” published in 2022, № 12 of the journal. It analyzes the results of the 55th National Conference of the African National Congress of South Africa, at which Cyril Ramaphosa was re-elected as president of this party. Information about other members of the new leadership of the ANC and the changes in the government of the country that followed the conference are also given.
The most important of the 11 resolutions adopted at the conference are considered. It is indicated that they give an impartial assessment of the situation in South Africa: “…the ANC-led democratic movement is increasingly losing strategic initiative and moral high-ground, while the counter-revolution is gaining confidence about the possibility to remove the ANC from power and ultimately derail the transformation of South Africa...”
The words are quoted from the resolution of the Conference on International Relations that the armed conflict in Ukraine “can no longer be described simply as a Russia-Ukraine war, it is primarily a conflict between the United States and US-led NATO military alliance and Russia...”
It is concluded that although Cyril Ramaphosa won a landslide victory in the ANC presidential election and secured the majority support in the new composition of the ANC National Executive Committee, his struggle against charges related to theft on his farm is going with varying success, and that the results of the investigation may shift the scales in one direction or another in the upcoming 2024 general elections.
ANALYSIS OF ENGLISH TEXTBOOK FOR FIFTH GRADE ELEMENTARY SCHOOL
Authors: Azaini Tahriidl Nur Khoiroh , Ambarwati Evi Karlina 
Published: June 2023

The purpose of this study is to evaluate the English language textbook from Ministry of Education and Culture (MOEC) for grade 5 Elementary School Level, entitled “My Next Word 5”. As an evaluation method, content-analysis was used in this study. To evaluate this book, the researchers adapt the instrument from Minister of Education and Culture Regulation Number 8 of 2016 and the book evaluation from Cunnings worth (1995); (1) Materials, (2) Language (3) Materials presenting (4) Graphic. As a result of the evaluation, it was found that the textbook is suitable for learners in materials, language i.e., there was a topic that relevant with the curriculum, the content of the book is more practical so that it can improve students’ skills, there was reflection table for student on the last page in every page. This book meets the criteria, but there are a few things that could be improved, such as the presentation of culture that is balanced with the culture of the language being studied.
Pengaruh Pembangunan Jalan Layang Tol Jakarta Cikampek II terhadap Pembentukan Struktur Perekonomian Jawa Barat
Authors: Usman M Taufik 
Published: June 2023

Penelitian ini dilakukan dengan menggunakan pendekatan model input output untuk mengetahui pengaruh dan peranan investasi di sektor konstruksi (pembangunan infrastruktur jalan tol layang Jakarta-Cikampek II) dalam pembentukan struktur perekonomian Jawa Barat dengan menggunakan data tabel input-output Provinsi Jawa Barat Tahun 2015 Atas Dasar Harga Produsen yang diperoleh dari Badan Pusat Statistik (BPS) Jawa Barat. Dari penelitian ini ditemukan bahwa sektor konstruksi memiliki pengaruh dan peranan yang kuat terhadap pembentukan struktur perekonomian Jawa Barat. Selain itu ditemukan pula adanya keterkaitan yang jelas antara pembangunan infrastruktur dan pertumbuhan ekonomi (elastisitas infrastruktur) di Jawa Barat.

Kata kunci: elastisitas infrastruktur, dampak Investasi, input-output, jalan tol, konstruksi.

Abstract
This research was conducted using input-output model approach to determine the effect and role of investment in the construction sector (infrastructure development of the Jakarta-Cikampek II elevated toll road) in forming of the economic structure of West Java using input-output table data of West Java Province in 2015 on the basis of producer prices. obtained from the Central Statistics Agency (BPS) West Java. The research found that the construction sector has a strong influence and role toward structure of the economy of West Java. In addition, it was also found that there was a clear link between infrastructure development and economic growth (infrastructure elasticity) in West Java.

Keywords: infrastructure elasticity, investment impact, input-output, toll roads, construction.
Investasi Keuangan Haji Melalui Sukuk Negara : Model Maqashid Al-Syari’ah
Authors: Husnurrosyidah Husnurrosyidah , Hadi Nor 
Published: June 2023

Penelitian ini menggunakan metode deskriptif argumentatif. Investasi dana haji ke dalam sukuk sesuai dengan prinsip syariah berdasarkan akad ijarah, mudarabah, musyarakah, istishna’, salam dan akad lainnya atau kombinasi akad sepanjang tidak bertentangan dengan prinsip syariah serta diawasi oleh DSN-MUI dan OJK. Konsep maqashid al-syari’ah yang terdiri atas dimensi al-din, al-nafs, al-aql, al-nasl dan al-mal telah terdapat pada keseluruhan manfaat sukuk sehingga terpenuhinya kebutuhan-kebutuhan daruriyyat, hajiniyat dan tahsiniat dalam investasi sukuk. Oleh karena itu, berdasarkan model maqashid al-syari’ah investasi sukuk pada dana haji Indonesia merupakan investasi yang bernilai maslahah.

Kata Kunci : Sukuk; Dana Haji; Maqashid Al-Syari’ah.

Abstract
This research method uses descriptive argumentative. The hajj fund investment into sukuk is in accordance with sharia principles based on the ijarah, mudarabah, musyarakah, istishna', salam and other contract agreements or contract combinations not conflict with sharia principles and there are supervised by DSN-MUI and OJK. The concept of maqashid al-syari'ah which consists of the dimensions of al-din, al-nafs, al-aql, al-nasl and al-mal has been found in all the benefits of sukuk so that the needs of daruriyyat, hajiniyat and tahsiniat are met in sukuk investment. Therefore, sukuk based on the maqashid al-syari'ah model for Indonesian hajj fund investment because there are maslahah value.

Keywords : Sukuk; Hajj Fund; Maqashid Al-Syari’ah.
Analisis Penentu Strategi Positioning dalam Meningkatkan Pangsa Pasar Telekomunikasi
Authors: Bahren Zul 
Published: June 2023

Persaingan bisnis telekomunikasi di Indonesia semakin ketat. Apabila perusahaan tidak mempunyai strategi pemasaran yang tepat akan kalah dengan pesaing. Salah satunya adalah Strategi Positioning bagaimana menempatkan produk dalam pikiran pelanggan, sehingga dianggap beda dengan produk pesaing. Untuk merancang Strategi Positioning ini perlu diketahui faktor apa saja yang paling berpengaruh dilihat dari persepsi konsumen. Apabila faktor-faktor ini sudah diketahui baru dirancang Strategi Positioning, sehinggan Pansa Pasar dapat dipertahankan dan ditingkatkan. Sebagai studi kasus penulis mengambil wilayah penelitian di PT Telkom Kawasan Timur Indonesia, Divisi Regional VII (DIVRE VII). Penelitian ini memadukan teori Bauran Pemasaran 7P dengan Positioning Pemasaran dengan menggunakan SEM (Sequantial Equational Model). Kemudian didapat hasilnya bahwa 7 faktor dalam Bauran Pemasaran semua mempengaruhi terhadap Startegi Positioning dan Strategi Positioning akan mempengaruh Pangsa Pasar. Semua faktor dalam Bauran Pemasaran baik Strategi harga, distribusi, promosi, layanan pelanggan, proses dan petugas akan mempengaruh Strategi Produk dengan ditunjukkan dengan angka 0,65-1,0. Terutama adalah Distribusi. Strategi Positioning harus diperbaiki supaya bisa mempertahankan dan menaikkan Pangsa Pasar.Kata Kunci: Pemasaran, Telkom, Telekomunikasi AbstractCompetition in the telecommunications business in Indonesia is getting tighter. If the company does not have the right marketing strategy, it will be unable with competitors. One of them is the Positioning Strategy, how to place the product in the mind of the customer, so that it is considered different from competitors' products. To design this Positioning Strategy, it is necessary to know what factors are most influencing in terms of consumer perceptions. If these factors are known, then a Positioning Strategy is designed so that the Market Competition can be maintained and improved. As a case study the authors took the research area at PT Telkom Timur Indonesia, Regional Division VII (DIVRE VII). This study combines the 7P Marketing Mix theory with Marketing Positioning using SEM (Sequantial Equational Model). Then the result shows that the 7 factors in the Marketing Mix all affect the Positioning Strategy and the Positioning Strategy will be affects Market Share. All factors in the Marketing Mix, including pricing, distribution, promotion, customer service, process and staff strategies, will influence the Product Strategy as indicated by the numbers 0.65-1.0. Primarily is Distribution. Positioning strategy must be improved in order to maintain and increase Market Share.Key Words: Marketing, Telecommunication, Telkom
Strategi Pengembangan Pariwisata Berkelanjutan Pantai Glagah Wangi Desa Tambak Bulusan
Authors: Sari Risti Lia , Diana Zummi Asma , Maulina Sarah 
Published: June 2023

Ditengah persaingan bisnis pariwisata saat ini harus diperhatikan dalam mempertahankan ataupun mengembangkan pariwisata tersebut agar dapat menjadi pariwisata yang berkelanjutan, Maka dari itu penulis meneliti bagaimana stategi pengembangan pariwisata berkelanjutan di Pantai GlagahWangi Desa Tambak Bulusan Kecamatan Karang Tengah Kabupaten Demak,dengan menggunakan Teknik analisis data yang digunakan dalam penelitian ini menggunakan teknik analisis deskriptif kualitatif, yaitu menganalisis, menggambarkan, dan meringkas berbagai kondisi, situasi dari berbagai data yang dikumpulkan berupa hasil wawancara atau pengamatan mengenai masalahyang diteliti dan terjadi di lapangan. Adapun tahapan dalam analisis data deskriptif kualitatif sebagai berikut: Pengumpulan data dalam penelitian ini diperoleh baik melalui observasi, wawancara, dan dokumentasi serta sumber bukti untuk meluruskan informasi, Penyajian data disusun berdasarkan pokokpokok data yang telah disajikan. Sajian data dalam penelitian ini selain dalam bentuk deskripsi, juga meliputi gambar atau skema, kegiatan serta tabel, Uji keabsahan data yang dilakukan peneliti dengan membandingkan data hasil pengamatan dengan wawancara dan membandingkannya dengan data observasi dan dokumentasi. Adapun hasil yang didapatkan peneliti agar Pantai Glagah Wangi itu menjadi Pariwisata yang dapat berkelanjutan antara lain adalah strategi adanya potensi Pantai Glagah Wangi, Peran Pemerintah untuk mendukung Pantai Glagah Wangi, partisipasi masyarakat untuk mendukung Pantai Glagah Wangi dan Persepsi wisatawan untuk mendukung Pantai Glagah Wangi di Desa Tambakbulusan Kecamatan Karang Tengah Kabupaten Demak
الطلاق ودوره في مشكلات الاطفال المحضونين
Authors: الزرعوني مريم , الطائي الاء 
Published: June 2023

يشكل الإستقرار الأسري حالة نسبية، ربما لاتتوفر دائماً بسبب عوامل عديدة، فقد تتعرض الأسرة الى أزمات ذات طبيعة إجتماعية ونفسية تؤدي الى تصدع العلاقات العائلية وإختلال توازنها، مثل الطلاق والذي يؤثر على الإسرة بشكل عام والأطفال بشكل خاص، لذا هدفت الدراسة التعرف الى مشكلات الأطفال المحضونين (السلوكية، الدراسية، النفسية، الإجتماعية ) ودلالة الفروق وفقا للنوع (ذكور-إناث)، والعمر عند حدوث الطلاق، وأعتمدت الدراسة المنهج الوصفي، وأستخدمت أساليب التحليل الكمية والنوعية، وتم جمع البيانات بالإعتماد على الاستبيان الذي عد لهذا الغرض، وأنطلقت الدراسة من النظرية البنائية كإطار نظري لها. وبلغ حجم عينة الدراسة (60) تلميذ وتلميذة، تم أختيارهم بالطريقة العشوائية البسيطة. ومن أهم النتائج التي توصلت إليها الدراسة، أن الأطفال يعانون من العديد من المشاكل (السلوكية والنفسية والدراسية والاجتماعية) بدرجة تتراوح من الكبير الى المتوسط، و توجد فروق ذات دلالة إحصائية للمتغيرات الديموغراقية الجنس والعمر، وأوصت الدراسة الوزارات المسؤولة لتفعيل دور مراكز الاُسرة لتعزيز الاستقرار لدى الاطفال المحضونين.
Pengaruh Ekspor, Indeks Pembangunan Manusia dan Tenaga Kerja terhadap Pertumbuhan Ekonomi di Indonesia Periode 2005-2021
Authors: Vernanda Tri , Amiruddin Yahya  , Chahayu Astina  
Published: June 2023

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh Pengaruh Ekspor, Indeks Pembangunan Manusia dan Tenaga Kerja terhadap Pertumbuhan Ekonomi di Indonesia Periode 2005-2021. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan data sekunder dari tahun 2005-2021. Metode analisis data menggunakan persamaan regresi linier berganda, uji t, uji F dan uji koefisien determinasi (R2). Hasil penelitian dengan uji persamaan regresi linier berganda serta uji secara parsial diketahui bahwa ekspor berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi Indonesia tahun 2005-2021. Demikian Indeks Pembangunan Manusia juga berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi di Indonesia tahun 2005-2021. sementara tenaga kerja berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi di Indonesia sejak tahun 2005-2021. Hasil uji F diketahui secara simultan ekspor, Indeks Pembangunan Manusia dan tenaga kerja mempunyai pengaruh signifikan terhadap variabel pertumbuhan ekonomi. Oleh karena itu dapat disimpulkan bahwa model regresi dapat digunakan untuk memprediksi pengaruhnya terhadap pertumbuhan ekonomi. Hasil uji koefisien determinasi (R2) diperoleh bahwa ekspor, indeks pembangunan manusia dan tenaga kerja dapat menjelaskan variabel pertumbuhan ekonomi sebesar 68,4% dan sisanya sebesar 31,6% dijelaskan faktor-faktor lain yang tidak diteliti pada penelitian ini. Kepada pemerintah sebaiknya ekspor ditingkatkan dengan memenuhi permintaan luar negeri dan IPM terus ditingkatkan melalui anggaran untuk pendidikan dan kesehatan serta ketepatan dalam pengelolaan dana tersebut. Kemudian tenaga kerja, agar positif terhadap pertumbuhan ekonomi perlu di serap pada berbagai sektor lapangan pekerjaan dengan pendapatan yang lebih tinggi
Pengaruh Emotional Demand, Emotional Exhaustion, dan Abusive Supervision terhadap Turnover Intention
Authors: Putri Nabila Eka , Tiarapuspa Tiarapuspa 
Published: June 2023

The purpose of this study is to analyze the influence of emotional demand, emotional exhaustion, and abusive supervision on turnover intention. In this study, primary data was collected using a questionnaire on a google form filled out by Trisakti University students who were already working. The data collection method uses the purposive sampling method with a sample of 165 samples. The data processing techniques used in this study were testing instruments such as validity and reliability tests and Structural Equation Modeling (SEM) using SPSS version 25 and AMOS version 24. The results of this study revealed that emotional demand has a significant influence on turnover intention, emotional exhaustion has a significant influence on turnover intention, and abusive supervision has a significant influence on turnover intention.
Assessment of Fitness for Air travel in Patients with Pulmonary Diseases
Authors: Mamun SM Abdullah Al , Haque Ziaul , Jahan Rowshne , Md Sharif , Islam Qazi Tariqul 
Published: June 2023

During air travel, increasing hypoxia with altitude ascent is a potentially serious problem for patients with hypoxemic chronic airway obstruction (CAO). Travel by air is the most popular way of transport nowadays & estimated that each year worldwide, more than 3 billion passengers travel by air & 736 million in the United States alone. For most passengers, even those with respiratory disease, air travel is safe and comfortable. Some patients with COPD &other Chronic Lung diseases may be at risk but, with screening, these patients can be identified and most of them can travel safely with supplemental oxygen. Some patients with chronic lung disease may have mild hypoxemia at sea level but during air travel in a hypobaric hypoxic environment, compensatory pulmonary mechanisms may be inadequate despite normal sea-level oxygen requirements. In addition, compensatory cardiovascular mechanisms may be less effective in some patients who are unable to increase cardiac output. Air travel also presents an increased risk of venous thromboembolism. It's estimated that, almost 1 medical emergency for every 600 flights. Respiratory symptoms accounted for 12% of all these in-air emergencies.
Pulse Volume 12-14 2020-2022 p.16-21
Exosomes - A Potential Candidate to Combat Covid-19 and A Future Emerging Nanotechnology with Diverse Perspectives
Authors: Khan Md Abu Quoreshi 
Published: June 2023

Corona virus causes severe contagious acute respiratory syndrome known as coronavirus disease 2019 (COVID-19). Several initiatives have been taken to tackle so far. One of them, being therapy based biological nano particles “Exosomes”. Administration of exosomes loaded with immunomodulatory cargo in combination with antiviral drugs will be a promising approach. This study deals with the exosomal isolation techniques of the Bruton Tyrosine Kinase (BTK) protein from cells. It represents initial trials to establish a method to isolate exosomes from human B cells.
Pulse Volume 12-14 2020-2022 p.22-25
Functional Ingredients for specialized Foods: Issues to be Addressed
Authors: Kodentsova V. M. , Risnik D. V. , Kryukova E. V. , Dariy S. G. 
Published: June 2023

Review was carried out using the RSCI, Google Scholar, Pubmed, and ReserchGate databases. When biologically active substances (BAS) are used as functional ingredients in the composition of specialized food products (SPP) of dietary therapeutic and dietary preventive nutrition, the problems of choosing their dose arise. There are epidemiological data on the level of consumption of BAS with food, an associative relationship between the level of consumption of biologically active substances and the risk of diseases, as well as the results of assessing clinical efficacy are described. The content of BAS is regulated by regulatory documents that establish an adequate and upper permissible level of consumption as part of the SPP.The purpose of the review is to assess the level of dietary intake of curcumin, carotenoids, β-glucans, and taurine, and to compare the doses allowed for use as part of the SPP with doses that provide a clinical effect. An analysis of literature data showed that the consumption of taurine with a normaldiet is 50–400 mg, curcumin – 10–1500 mg, β-carotene – 0.8–10 mg, lycopene – 5–10.5 mg, lutein – 1–3 mg, zeaxanthin – 0.1–0.6 mg, cereal β-glucans – 0.7–2.8 g, mushroom β-glucans – 0.9–1.8 g. With the exception of β-glucans, especially cereals, these values do not exceed the current upper allowable consumption level as part of the SPP. The results of clinical trials have shown that effective daily doses for lutein are 15 mg, taurine are 1.5–3 g, curcumin are 300–1600 mg, cereal β-glucans are 3–8 g, mushroom and yeast β-glucans are about 1 g. These data indicate the need to increase the amount of BAS as part of the SPP of dietary therapeutic nutrition to clinically justified values. At the same time, the given data indicate the expediency of differentiating the SPP, depending on the doses of BAS, into 2 categories: SPP for preventive and SPP for therapeutic action. SPP for dietary preventive nutrition is necessary to compensate the insufficient intake of essential micronutrients and achieve an adequate level of consumption of BAS, which will reduce the risk of alimentary-dependent diseases. In order to provide a clinical effect in pathological conditions, dietary therapeutic SPP should contain higher doses of biologically active substances that exceed the adequate intake level, but do not reach the upper safe intake level.
Comorbid food allergy in patients with congenital epidermolysis bullosa
Authors: Galimova A. A. , Makarova S. G. , Murashkin N. N. , Snovskaya M. A. 
Published: June 2023

Introduction. Inherited epidermolysis bullosa belongs to the group of severe rare hereditary mechanobullous diseases. Often, the skin pathological process is difficult to treat, which leads to a decrease in the quality of life of such patients. The mechanism of development of transcutaneous sensitization in this category of patients is not excluded. This issue remains a very relevant area for study, given the characteristic nutritional deficiency and the difficulties that arise in the formation of the diet.The aim: to assess the frequency of occurrence and characteristics of food sensitization in children with epidermolysis bullosa.Materials and methods: the group included 164 children with epidermolysis bullosa (45 with rapid detection and 119 with dystrophic). For all patients, an assessment of the risk of an allergic history, determination of the total level of IgE and specific IgE of blood serum to the most significant food allergens (UniCAP system, Thermo Fisher Scientific). Results: food sensitization was detected in 34.1 % of children with epidermolysis bullosa (in 38.7 % of cases with dystrophic and in 24.4 % with a simple form of epidermolysis bullosa). Among the manifestations of food allergy in both groups, skin symptoms were more common. The most common etiological factors were products containing cow’s milk protein, eggs, and cereals. In the group of children with comorbid food allergies and epidermolysis bullosa, high and extremely high levels of total IgE were most common.Conclusion: a high frequency of food sensitization in patients with epidermolysis bullosa, was shown, which is important not only from a scientific, but also from a practical point of view. Given the nutritional deficiency characteristic of this disease, the complexity of nutritional support, the presence of comorbid food allergies should be taken into account when recommending nutrition and selecting therapeutic products for this category of patients.