bluuebunny/crossref_metadata_2025_split huggingface dataset:
Encapsulation of hydroxycitronellal in β-cyclodextrin and the characteristics of the inclusion complex
Authors: Zhu Guangyong , Xiao Zuobing , Zhou Rujun , Liu Junhua , Zhu Guangxu 
Published: February 2023

Abstract
Hydroxycitronellal has been widely used in foods, beverages, perfumery and cosmetics. It can also be used to treat anxiety. The major drawbacks regarding the use of hydroxycitronellal are related to water insolubility, volatility, instability, and sensitization. To overcome these concerns, β-cyclodextrin was adopted as wall material to encapsulate hydroxycitronellal in this work. Hydroxycitronellal-β-cyclodextrin inclusion complex was prepared and the product was characterized. The interaction of hydroxycitronellal and β-cyclodextrin, and the assembly of hydroxycitronellal-β-cyclodextrin inclusion complex were investigated by molecular simulation (MM). The results showed that hydroxycitronellal loading capacity was 8.5%. The thermal stability and lastingness of hydroxycitronellal were improved by the formation of the inclusion complex. The minimum binding energy was –151.2 kJ/mol. Among the perpendicular, staggered parallel and ideally parallel orientation of the inclusion complexes, the minimum energy value was found for the staggered parallel arrangement. These basic data are useful to understand the interaction between hydroxycitronellal and β-cyclodextrin.
Head and neck cancers of unknown primary: A diagnostic and therapeutic challenge
Authors: Enache Raluca , Sarafoleanu Dorin , Sarafoleanu Codrut 
Published: February 2023

Abstract
Head and neck cancers of unknown primary (CUP) represent up to 10% of all cancers located in the head and neck. True cancers of unknown primary, which remain of undetected primary origin after a correct clinical, imaging, surgical evaluation, have a reported frequency of between 1% and 2%. Cancers of unknown primary of the head and neck are a diagnostic challenge, considering that their main clinical manifestation is represented by the appearance of lymph node metastases in the cervical region.
In general, the detection of cancers with an unknown starting point is late, difficult, with significant therapeutic failure. The diagnostic-therapeutic approach starts from the histopathological structure of the lymph node metastasis and continues with a correct and complete imaging evaluation.
In this review are presented the diagnosis and therapeutic challenges and importance of head and neck cancers with unknown primary.
FUNGSI CANTOR-LEBESGUE DAN HIMPUNAN TERUKUR LEBESGUE
Authors: Herlinawati Elin 
Published: February 2023

Ukuran Lebesgue diperkenalkan oleh Henri Leon Lebesgue. Ukuran ini memetakan aljabar ke - ke[0, ~] . Hal ini menunjukkan suatu himpunan dapat berukuran Lebesgue positif atau nol. Salah satu himpunan yang mempunyai ukuran Lebesgue nol adalah himpunan Cantor yang faktanya termasuk kedalam himpunan tak terhitung. Artinya, ukuran Lebesgue tidak menyatakan banyaknya anggota di dalam suatu himpunan. Lebih jauh lagi, Teorema Vitali menjamin adanya himpunan yang tidak terukur Lebesgue. Pencarian suatu fungsi yang dapat memetakan suatu himpunan terukur kedalam himpunan yang tidak terukur mejadi fokus pada artikel ini. Fungsi ini diperoleh dengan menjumlahkan fungsi Cantor dengan fungsi linear. Karena ukuran yang digunakan adalah ukuran Lebesgue, maka fungsi ini disebut sebagai fungsi Cantor-Lebesgue. Kemudian, artikel ini juga membahas suatu fungsi kontinu yang memetakan himpunan terukur Lebesgue kedalam himpunan yang tidak terukur Lebesgue.
ANALISIS KEMAMPUAN TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE (TPACK) MAHASISWA PROGRAM STUDI PENDIDIKAN MATEMATIKA PADA MATA KULIAH MICROTEACHING DI MASA PANDEMI COVID 19
Authors: Satriawati Gusni , Mas'ud Afidah , Dwirahayu Gelar , Dahlan Jarnawi Afgani , Cahya Endang 
Published: February 2023

Mata kuliah Microteaching merupakan salah satu matakuliah yang wajib ditempuh oleh mahasiswa pada program studi pendidikan matematika UIN Syarif Hidayatullah Jakarta. Mata kuliah ini bertujuan untuk melatih mahasiswa dalam membuat rencana pembelajaran dan sekaligus mengimplementasikannya di dalam kelas. Penelitian ini dilaksanakan pada tahun ajaran 2020/2021 dimana kegiatan pembelajaran masih terkena dampak pandemi covid 19. Oleh karena itu, dalam merencanakan pembelajaran mahasiswa harus memiliki keterampilan dalam mengoperasikan teknologi sebagai media pembelajaran. Penelitian ini mendeskripsikan tentang kemampuan Technological Pedagogical Content Knowledge (TPACK) mahasiswa calon guru matematika dalam merancang Rencana Pelaksanaan Pembelajaran (RPP) dan simulasi pembelajaran matematika. Metode penelitian yang digunakan adalah studi eksplorasi deskriptif. Sampel yang digunakan adalah mahasiswa semester tujuh sebanyak 17 orang. Terdiri dari 1 orang laki-laki dan 16 orang perempuan . Hasil penelitian menunjukkan bahwa ketiga indikator dari TPACK yaitu : 1) Pedagogical Knowledge , 2) Content Knowledge mahasiswa dan 3) Technologocal Knowledge mahasiswa cukup baik. Kesimpulan dalam penelitian ini yaitu mahasiswa prodi pendidikan matematika sudah memiliki kemampuan TPACK pada kategori cukup baik dalam hal penyusunan rencana pembelajaran dan pelaksananaan pembelajaran yang mengintegrasikan antara teori pembelajaran/strategi pembelajaran, materi dan teknologi.
VIRAL MARKETING DI MEDIA SOSIAL SEBAGAI GAYA BARU KOMUNIKASI PEMASARAN
Authors: Sari Wulan Purnama , Paramita Sinta 
Published: February 2023

Tren penggunaan media sosial sebagai alat pemasaran atau marketing ini memunculkan istilah baru yang disebut juga sebagai viral marketing. Viral marketing secara sederhana dapat diartikan sebagai sebuah teknik pemasaran yang memanfaatkan media sosial atau disebut juga word of mouth dengan menggunakan internet dan media sosial. Viral marketing ini banyak dimanfaatkan oleh pelaku bisnis, termasuk pelaku bisnis yang bergerak di bidang healthy catering atau katering diet. Bisnis katering diet ini, sekarang juga sedang menjadi tren, sebagai pendukung tren gaya hidup sehat. Salah satu penyedia jasa katering diet adalah GR, bisnis katering diet yang menggunakan teknik viral marketing, dengan media sosial utama Instagram dan TikTok. Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan viral marketing di media sosial dalam penerapannya oleh pelaku bisnis healthy catering dan untuk mendeskripsikan proses implementasi viral marketing sebagai sebuah gaya baru komunikasi pemasaran. Penelitian menggunakan pendekatan kualitatif dengan metode studi kasus. Data diperoleh melalui wawancara mendalam dengan narasumber dan observasi. Hasil penelitian menunjukkan terdapat beberapa faktor utama dalam melakukan viral marketing di media sosial, yaitu jenis konten, waktu unggah, dan penggunaan hashtag.

The trend of using social media as a marketing or marketing tool has given rise to a new term which is also known as viral marketing. Viral marketing can simply be interpreted as a marketing technique that utilizes social media or also called word of mouth by using the internet and social media. Viral marketing is widely used by business people, including business people engaged in healthy catering or diet catering. This diet catering business, is now also becoming a trend, as a supporter of a healthy lifestyle trend. One of the diet catering service providers is GR, a diet catering business that uses viral marketing techniques, with the main social media being Instagram and TikTok. This study aims to analyze and describe viral marketing on social media in its application by healthy catering businesses and to describe the process of implementing viral marketing as a new style of marketing communication. The research uses a qualitative approach with a case study method. Data were obtained through in-depth interviews with informants and observations. The results of the study show that there are several main factors in doing viral marketing on social media, namely the type of content, upload time, and the use of hashtags.
Comparison of Pulsed Electroacoustic Measurements and AF-NUMIT3 Modeling of Polymers Irradiated with Monoenergetic Electrons
Authors: Gibson Zachary , Dennison J. R. , Beecken Brian , Hoffmann Ryan 
Published: February 2023

Successful spacecraft design and charging mitigation techniques require precise and accurate knowledge of charge deposition profiles. This paper compares models of charge deposition and transport using a venerable deep dielectric charging code, AF-NUMIT3, with direct measurements of charge profiles via pulsed electroacoustic (PEA) measurements. Eight different simulations were performed for comparison to PEA experiments of samples irradiated by 50 or 80 keV monoenergetic electrons in vacuum and at room temperature. Two materials, polyether-ether ketone (PEEK) and polytetrafluoroethylene (PTFE), were chosen for their very low conductivities so that minimal charge migration would occur between irradiation and PEA measurements. PEEK was found to have low acoustic attenuation, while PTFE has high acoustic attenuation through the sample thicknesses of 125 and [Formula: see text] for each material. The measurements were directly compared to AF-NUMIT3 simulations to validate aspects of the code and to investigate the importance of various simulation options, as well as to characterize the PEA instrumentation, measurement methods, and signal processing used. The measurement and simulation values for magnitude of charge deposition, penetration depth, and charge deposition spatial profiles are largely in agreement, though spatial and temporal distributions in incident electron flux and effects of radiation-induced conductivity (RIC) and delayed RIC during the deposition process complicate the process. This work provides an experimental validation of the AF-NUMIT3 deep dielectric charging code and insight into the accuracy and precision of the PEA method.
Uma abordagem geral da doença de Alzheimer
Authors: Reis Anna Júlia Tamiozzo , Siqueira Emílio Conceição de 
Published: February 2023

Objetivo: Analisar as características da doença de Alzheimer (DA). Revisão bibliográfica: A DA é a causa mais comum de comprometimento cognitivo ou demência em indivíduos com mais de 65 anos, com 47 milhões de pessoas vivendo com a doença em todo o mundo. Esta pode ser definida como uma doença neurodegenerativa lentamente progressiva caracterizada por placas neuríticas e emaranhados neurofibrilares como resultado do acúmulo do peptídeo beta-amilóide (Aβ) no lobo temporal medial e nas estruturas neocorticais. A DA tipicamente se apresenta com comprometimento cognitivo amnéstico proeminente e posterior acometimento cognitivo. Considerações finais: A DA é um grave problema de saúde pública por representar uma das principais causas de morte mundialmente. Seu diagnóstico envolve uma abordagem interdisciplinar cuja finalidade é avaliar os sinais e sintomas clínicos desta doença multifatorial e as alterações bioquímicas. A terapêutica da doença perpassa por medidas não farmacológicas, na qual a principal consiste na atividade física e o tratamento farmacológico atual tem o objetivo de atrasar a progressão da doença, mas sem efeito curativo, sendo composta pelos inibidores da colinesterase e pela memantina.
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP STAPHYLOCOCCUS EPIDERMIDIS DAN PITYROSPORUM OVALE
Authors: Simanullang Meriana , Khaitami Muammar , Sihotang Saipul , Budi Andre 
Published: February 2023

Tujuan dari penelitian ini adalah untuk mengetahui senyawa metabolit sekunder yang terdapat pada daun belimbing wuluh dan efektivitasnya dalam menghambat pertumbuhan Staphylococcus epidermidis dan Pityrosporum ovale. Metode yang digunakan pada penelitian ini adalah eksperimental laboratorium dengan perlakuan ekstrak belimbing wuluh yaitu 5%, 10%, 15%, 20% dan 25%. data dianalisa menggunakan software SPSS Versi 23. Hasil skrining fitokimia ekstrak belimbing wuluh terdapat senyawa metabolit sekunder yang potensial seperti flavonoid, alkaloid, terpenoid, tannin, saponin, steroid, dan polifenol. Pemberian 100% ekstrak belimbing wuluh merupakan perlakuan terbaik dalam menekan pertumbuhan bakteri S. epidermidis dan P. ovale dengan rata-rata daya hambat yaitu 11,33 mm dan 11,50 mm.
Pengaruh Kemalisme Terhadap Undang-Undang Poligami di Turki
Authors: Kamilia Nur 
Published: February 2023

This paper aims to discuss the issu of the influence of Kemalism on the polygamy law in Turkey to disribe universally the influence of Kemalism on the polygamy law in Turkey by firs knowing Mustafa Kemal’s mission in the information of a republic there. This paper will try to answer haw Kemalism has a major influence on the family law, especially the polygami law. this paper includes the results of the qualitatif research with data sources and documents from a number og books and articels as well as as from other data sources related to this paper. The result of this paper is to find a complete overhaul of state regulations regarding the family right in 1917 in which it is explained that polygamy is not prohibited but still on condition that the husband can be fair to his wives and the wafe may write a divorce not before the marriage after this (polygamy). If the man ignores this, than the divorce has the right to be carried out into the Turkish Civil Code of 1926, which explains the absolute prohibition of polygamy. This cange occurred because of the influence of Kemalism on the Turkish state. From this infuence there is rule regarding violations againts people who practice polygamy. However, there are no rules that explicitly regulate sanctions for such violation The Turkish Family Law Of Cyprus 1951. But basically the lawimplicitly exsplain that polygamy in Turkey is not permitted and those who violate it will get a penalty.
Signalement des violences conjugales aux urgences d’un centre hospitalier universitaire
Authors: Edange C. , El adli A. , Thierry A. , Gennai S. 
Published: February 2023

Objectif: En 2019, 213 000 femmes (18–75 ans) étaient victimes de violences conjugales physiques et/ou sexuelles en France, et 18 % portaient plainte. Dans ce contexte, le CHU de Reims, le Procureur de la République de Reims et l’association « LE MARS France Victime 51 » ont mis en place un dispositif de signalement des violences conjugales au sein des urgences. L’objectif principal de notre étude était de décrire la population de patients consultant aux urgences, pour lesquels des violences conjugales étaient avérées ou soupçonnées au cours de l’interrogatoire. Les objectifs secondaires étaient de décrire la sous-population de patients acceptant le signalement au Procureur de la République et les facteurs associés à l’acceptation du signalement.Matériel et méthodes: Il s’agissait d’une étude observationnelle, prospective, monocentrique sur une période de six mois. Si les patients acceptaient l’étude, un questionnaire était renseigné avec recueil des informations relatives aux faits rapportés, aux antécédents et aux données issues de la consultation aux urgences.Résultats: Quarante-sept patients ont été inclus, avec un âge moyen de 34 ans, et 46 était des femmes. Trente-trois (70 %) ont accepté le signalement. Dans le groupe « Accepte », l’âge était plus élevé (p< 0,001), et l’abus d’alcool par le conjoint était plus fréquent (p= 0,045). Les fractures n’étaient présentes que dans le groupe « Accepte ». Dans le groupe « Refuse », le premier enfant était plus jeune (p= 0,007), et les antécédents de violence conjugale par un autre agresseur étaient plus fréquents (p= 0,025). En analyse multivariée, seuls l’âge et le souhait de porter plainte restaient significativement associés au signalement (p= 0,006 etp= 0,03 respectivement).Conclusion: Cette étude a montré que le signalement avait un taux d’acceptation élevé parmi les victimes, facilitant le processus judiciaire, et a permis d’identifier les facteurs associés au refus de signalement.
Automated Video Analysis of Audio-Visual Approaches to Predict and Detect Mild Cognitive Impairment and Dementia in Older Adults
Authors: Chu Che-Sheng , Wang Di-Yuan , Liang Chih-Kuang , Chou Ming-Yueh , Hsu Ying-Hsin , Wang Yu-Chun , Liao Mei-Chen , Chu Wei-Ta , Lin Yu-Te 
Published: February 2023

Background: Early identification of different stages of cognitive impairment is important to provide available intervention and timely care for the elderly. Objective: This study aimed to examine the ability of the artificial intelligence (AI) technology to distinguish participants with mild cognitive impairment (MCI) from those with mild to moderate dementia based on automated video analysis. Methods: A total of 95 participants were recruited (MCI, 41; mild to moderate dementia, 54). The videos were captured during the Short Portable Mental Status Questionnaire process; the visual and aural features were extracted using these videos. Deep learning models were subsequently constructed for the binary differentiation of MCI and mild to moderate dementia. Correlation analysis of the predicted Mini-Mental State Examination, Cognitive Abilities Screening Instrument scores, and ground truth was also performed. Results: Deep learning models combining both the visual and aural features discriminated MCI from mild to moderate dementia with an area under the curve (AUC) of 77.0% and accuracy of 76.0%. The AUC and accuracy increased to 93.0% and 88.0%, respectively, when depression and anxiety were excluded. Significant moderate correlations were observed between the predicted cognitive function and ground truth, and the correlation was strong excluding depression and anxiety. Interestingly, female, but not male, exhibited a correlation. Conclusion: The study showed that video-based deep learning models can differentiate participants with MCI from those with mild to moderate dementia and can predict cognitive function. This approach may offer a cost-effective and easily applicable method for early detection of cognitive impairment.
The Heritability of Subjective Cognitive Complaints in Older Australian Twins
Authors: Selwood Amanda E. , Catts Vibeke S. , Numbers Katya , Lee Teresa , Thalamuthu Anbupalam , Wright Margaret J. , Sachdev Perminder S. 
Published: February 2023

Background: Subjective cognitive complaints (SCCs) may be a precursor to mild cognitive impairment (MCI) and dementia. Objective: This study aimed to examine the heritability of SCCs, correlations between SCCs and memory ability, and the influence of personality and mood on these relationships. Methods: Participants were 306 twin pairs. The heritability of SCCs and the genetic correlations between SCCs and memory performance, personality, and mood scores were determined using structural equation modelling. Results: SCCs were low to moderately heritable. Memory performance, personality and mood were genetically, environmentally, and phenotypically correlated with SCCs in bivariate analysis. However, in multivariate analysis, only mood and memory performance had significant correlations with SCCs. Mood appeared to be related to SCCs by an environmental correlation, whereas memory performance was related to SCCs by a genetic correlation. The link between personality and SCCs was mediated by mood. SCCs had a significant amount of both genetic and environmental variances not explained by memory performance, personality, or mood. Conclusion: Our results suggest that SCCs are influenced both by a person’s mood and their memory performance, and that these determinants are not mutually exclusive. While SCCs had genetic overlap with memory performance and environmental association with mood, much of the genetic and environmental components that comprised SCCs were specific to SCCs, though these specific factors are yet to be determined.
Auditory Event-Related Potentials in Older Adults with Subjective Memory Complaints
Authors: Tarawneh Hadeel Y. , Jayakody Dona M.P. , Verma Shipra , Doré Vincent , Xia Ying , Mulders Wilhelmina H.A.M. , Martins Ralph N. , Sohrabi Hamid R. 
Published: February 2023

Background: Auditory event-related potentials (AERPs) have been suggested as possible biomarkers for the early diagnosis of Alzheimer’s disease (AD). However, no study has investigated AERP measures in individuals with subjective memory complaints (SMCs), who have been suggested to be at a pre-clinical stage of AD. Objective: This study investigated whether AERPs in older adults with SMC can be used to objectively identify those at high risk of developing AD. Methods: AERPs were measured in older adults. Presence of SMC was determined using the Memory Assessment Clinics Questionnaire (MAC-Q). Hearing thresholds using pure-tone audiometry, neuropsychological data, levels of amyloid-β burden and Apolipoprotein E ( APOE) ɛ genotype were also obtained A classic two-tone discrimination (oddball) paradigm was used to elicit AERPs (i.e., P50, N100, P200, N200, and P300). Results: Sixty-two individuals (14 male, mean age 71.9±5.2 years) participated in this study, of which, 43 (11 male, mean age 72.4±5.5 years) were SMC and 19 (3 male, mean age 70.8±4.3 years) were non-SMC (controls). P50 latency was weakly but significantly correlated with MAC-Q scores. In addition, P50 latencies were significantly longer in Aβ+ individuals compared to Aβ– individuals. Conclusion: Results suggest that P50 latencies may be a useful tool to identify individuals at higher risk (i.e., participants with high Aβ burden) of developing measurable cognitive decline. Further longitudinal and cross-sectional studies in a larger cohort on SMC individuals are warranted to determine if AERP measures could be of significance for the detection of pre-clinical AD.
Bilateral Hippocampal Volume Mediated the Relationship Between Plasma BACE1 Concentration and Memory Function in the Early Stage of Alzheimer’s Disease: A Cross-Sectional Study
Authors: Yin Wenwen , Wan Ke , Zhu Wenhao , Zhou Xia , Tang Yating , Zheng Wenhui , Cao Jing , Song Yu , Zhao Han , Zhu Xiaoqun , Sun Zhongwu 
Published: February 2023

Background: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a key enzyme in the formation of amyloid-β (Aβ) protein. Increasing evidence suggests that BACE1 concentration is a potential biomarker for Alzheimer’s disease (AD). Objective: To evaluate the correlations between plasma BACE1 concentration, cognition, and hippocampal volume at different stages of the AD continuum. Methods: Plasma BACE1 concentrations were measured in 32 patients with probable dementia due to AD (ADD), 48 patients with mild cognitive impairment (MCI) due to AD, and 40 cognitively unimpaired (CU) individuals. Memory function was evaluated using the auditory verbal learning test (AVLT), and voxel-based morphometry was used to analyze bilateral hippocampal volumes. Correlation and mediation analyses were performed to investigate the associations between plasma BACE1 concentration, cognition, and hippocampal atrophy. Results: The MCI and ADD groups exhibited elevated BACE1 concentrations compared with the CU group after adjusting for age, sex, and apolipoprotein E ( APOE) genotype. Increased BACE1 concentration was found in AD continuum patients who were APOE ɛ4 carriers ( p < 0.05). BACE1 concentration was negatively associated with the scores of the subitems of the AVLT and hippocampal volume ( p < 0.05, false discovery rate correction) in the MCI group. Moreover, bilateral hippocampal volume mediated the relationship between BACE1 concentration and recognition in the MCI group. Conclusion: BACE1 expression increased in the AD continuum, and bilateral hippocampal volume mediated the effect of BACE1 concentration on memory function in patients with MCI. Research has indicated that the plasma BACE1 concentration might be a biomarker at the early stage of AD.