bluuebunny/crossref_metadata_2025_split huggingface dataset:
High on-aspirin treatment platelet reactivity and restenosis after percutaneous coronary intervention: results of the Intracoronary Stenting and Antithrombotic Regimen-ASpirin and Platelet Inhibition (ISAR-ASPI) Registry
Authors: Mayer Katharina , Ndrepepa Gjin , Schroeter Mira , Emmer Christopher , Bernlochner Isabell , Schüpke Stefanie , Gewalt Senta , Hilz Raphaela , Coughlan John Joseph , Aytekin Alp , Heyken Clarissa , Morath Tanja , Schunkert Heribert , Laugwitz Karl-Ludwig , Sibbing Dirk , Kastrati Adnan 
Published: February 2023

Abstract
Objective
The aim of this study was to assess the association between high on-aspirin treatment platelet reactivity (HAPR) and the subsequent risk of restenosis after percutaneous coronary intervention (PCI) with predominantly drug-eluting stents.

Background
The association between HAPR and subsequent risk of restenosis after PCI is unclear.

Methods
This study included 4839 patients undergoing PCI (02/2007–12/2011) in the setting of the Intracoronary Stenting and Antithrombotic Regimen-ASpirin and Platelet Inhibition (ISAR-ASPI) registry. Platelet function was assessed with impedance aggregometry using the multi-plate analyzer immediately before PCI and after intravenous administration of aspirin (500 mg). The primary outcome was clinical restenosis, defined as target lesion revascularization at 1 year. Secondary outcomes included binary angiographic restenosis and late lumen loss at 6- to 8-month angiography.

Results
The upper quintile cut-off of platelet reactivity measurements (191 AU × min) was used to categorize patients into a group with HAPR (platelet reactivity > 191 AU × min; n = 952) and a group without HAPR (platelet reactivity ≤ 191 AU × min; n = 3887). The primary outcome occurred in 94 patients in the HAPR group and 405 patients without HAPR (cumulative incidence, 9.9% and 10.4%; HR = 0.96, 95% CI 0.77–1.19; P = 0.70). Follow-up angiography was performed in 73.2% of patients. There was no difference in binary restenosis (15.2% vs. 14.9%; P = 0.79) or late lumen loss (0.32 ± 0.57 vs. 0.32 ± 0.59 mm; P = 0.93) between patients with HAPR versus those without HAPR.

Conclusions
This study did not find an association between HAPR, measured at the time of PCI, and clinical restenosis at 1 year after PCI.

Graphical abstract
Twenty-year prospective cohort study of the association between a Japanese dietary pattern and incident dementia: the NILS-LSA project
Authors: Zhang Shu , Otsuka Rei , Nishita Yukiko , Tange Chikako , Tomida Makiko , Ando Fujiko , Shimokata Hiroshi , Arai Hidenori 
Published: February 2023

Abstract
Purpose
Evidence has suggested that adherence to a Japanese diet may be beneficial for health. However, its association with incident dementia remains unclear. The aim was to explore this association in older Japanese community-dwellers, taking apoprotein E genotype into consideration.

Methods
A 20-year follow-up cohort study involving 1504 dementia-free older Japanese community-dwellers (aged 65–82 years) living in Aichi Prefecture, Japan, was conducted. Based on a previous study, a 9-component-weighted Japanese Diet Index (wJDI9) score (range − 1 to 12) was calculated using 3-day dietary record data and used as an indicator of adherence to a Japanese diet. Incident dementia was confirmed by the Long-term Care Insurance System certificate, and dementia events occurring within the first 5 years of follow-up were excluded. A multivariate-adjusted Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia, and Laplace regression was used to estimate percentile differences (PDs) and 95% CIs (expressed in months) in age at incident dementia (i.e., dementia-free duration differences), according to tertiles (T1–T3) of wJDI9 scores.

Results
The median (IQR) follow-up duration was 11.4 (7.8–15.1) years. During the follow-up period, 225 (15.0%) cases of incident dementia were identified. Because the smallest prevalence of incident dementia was 10.7% for the T3 group of wJDI9 scores, to avoid inaccurately estimating the dementia-free duration of participants in the T3 group, the 11th PDs in age at incident dementia between the T1 and T3 groups of wJDI9 scores were estimated. A higher wJDI9 score was associated with a lower risk of incident dementia and a longer dementia-free duration difference. The multivariate-adjusted HR (95% CI) and 11th PDs (95% CI) in age at incident dementia for participants in the T1 vs. T3 group were 1.00 (reference) vs. 0.58 (0.40, 0.86), and 0 (reference) vs. 36.7 (9.9, 63.4) months, respectively. Each 1-point increase of the wJDI9 score was associated with a 5% lower risk of incident dementia (P value = 0.033) and 3.9 (0.3, 7.6) additional months of dementia-free duration (P value = 0.035). No differences were seen in sex or smoking status (current smoker vs. non-current smoker) at baseline.

Conclusion
These findings suggest that adherence to a Japanese diet defined by wJDI9 is associated with a lower risk of incident dementia in older Japanese community-dwellers, suggesting the benefit of the Japanese diet for dementia prevention.
Survivorship of the dual-mobility construct in elective primary total hip replacement: a systematic review and meta-analysis including registry data
Authors: Gardner Andrew , Macdonald Hamish , Evans Jonathan T. , Sayers Adrian , Whitehouse Michael R. 
Published: February 2023

Abstract
Introduction
Dislocation is a common complication associated with total hip replacement (THR). Dual-mobility constructs (DMC-THR) may be used in high-risk patients and have design features that may reduce the risk of dislocation. We aimed to report overall pooled estimates of all-cause construct survival for elective primary DMC-THR. Secondary outcomes included unadjusted dislocation rate, revision for instability, infection and fracture.

Methods
MEDLINE, EMBASE, Web of Science, Cochrane Library and National Joint Registry reports were systematically searched (CRD42020189664). Studies reporting revision (all-cause) survival estimates and confidence intervals by brand and construct including DMC bearings were included. A meta-analysis was performed weighting series by the standard error.

Results
Thirty-seven studies reporting 39 case series were identified; nine (10,494 DMC-THR) were included. Fourteen series (23,020 DMC-THR) from five national registries were included.
Pooled case series data for all-cause construct survival was 99.7% (95% CI 99.5–100) at 5 years, 95.7% (95% CI 94.9–96.5) at 10 years, 96.1% (95% CI 91.8–100) at 15 years and 77% (95% CI 74.4–82.0) at 20 years. Pooled joint registry data showed an all-cause construct survivorship of 97.8% (95% CI 97.3–98.4) at 5 years and 96.3% (95% CI 95.6–96.9) at 10 years.

Conclusions
Survivorship of DMC-THR in primary THR is acceptable according to the national revision benchmark published by National Institute for Clinical Excellence (NICE).
How to do a 3D uterus ultrasound?
Authors: Jonaityte Gertruda , Kagan Karl Oliver , Prodan Natalia Carmen , Hoopmann Markus 
Published: February 2023

AbstractThree-dimensional (3D) ultrasound is an invaluable tool in the detection and evaluation of many uterine anomalies and improves upon the traditional approach of two-dimensional (2D) ultrasonography. We aim to describe an easy way of assessing the uterine coronal plane using the basic three-dimensional ultrasound in everyday gynecological practice.
Constraints on the Nd-isotopic composition and nature of the last major influx of magma into the Bushveld Complex
Authors: Magson Justine , Roelofse Frederick , Bybee Grant , Bolhar Robert 
Published: February 2023

AbstractThe Pyroxenite Marker, a thin, orthopyroxene-dominated marker horizon, is observed towards the top of the Main Zone of the Bushveld Complex, where the last voluminous influx of magma into the Bushveld Complex is thought to have occurred. In an attempt to constrain the Nd-isotopic composition of the magma added at the level of the Pyroxenite Marker, a total of 21 whole-rock samples from a borehole (BH7771) drilled on the Central Sector of the Eastern Limb of the Bushveld Complex were analysed for their Sr–Nd isotopic ratios. Modelling suggests that the added magma had a unique Sr (87Sr/86Sri = 0.7063–0.7067) and Nd (ƐNdi on the order of − 5.9) isotopic composition, distinct from any of the rocks constituting the layered sequence below the Pyroxenite Marker. Dispersion of data points around the modelled isotopic (melt–melt) mixing curves is interpreted to reflect the incorporation of minerals derived from either the incoming or resident magmas into individual rock layers occurring across the Pyroxenite Marker interval, either in response to the mixing of minerals settling through a stratified magma column, or potentially through the intrusion and mixing of crystal-laden magmas with unique isotopic compositions from a sub-Bushveld staging chamber.
PMI estimation through metabolomics and potassium analysis on animal vitreous humour
Authors: Locci Emanuela , Stocchero Matteo , Gottardo Rossella , Chighine Alberto , De-Giorgio Fabio , Ferino Giulio , Nioi Matteo , Demontis Roberto , Tagliaro Franco , d’Aloja Ernesto 
Published: February 2023

Abstract
Introduction
The estimation of post-mortem interval (PMI) remains a major challenge in forensic science. Most of the proposed approaches lack the reliability required to meet the rigorous forensic standards.

Objectives
We applied 1H NMR metabolomics to estimate PMI on ovine vitreous humour comparing the results with the actual scientific gold standard, namely vitreous potassium concentrations.

Methods
Vitreous humour samples were collected in a time frame ranging from 6 to 86 h after death. Experiments were performed by using 1H NMR metabolomics and ion capillary analysis. Data were submitted to multivariate statistical data analysis.

Results
A multivariate calibration model was built to estimate PMI based on 47 vitreous humour samples. The model was validated with an independent test set of 24 samples, obtaining a prediction error on the entire range of 6.9 h for PMI < 24 h, 7.4 h for PMI between 24 and 48 h, and 10.3 h for PMI > 48 h. Time-related modifications of the 1H NMR vitreous metabolomic profile could predict PMI better than potassium up to 48 h after death, whilst a combination of the two is better than the single approach for higher PMI estimation.

Conclusion
The present study, although in a proof-of-concept animal model, shows that vitreous metabolomics can be a powerful tool to predict PMI providing a more accurate estimation compared to the widely studied approach based on vitreous potassium concentrations.
Online mental health training program for male-dominated organisations: a pre-post pilot study assessing feasibility, usability, and preliminary effectiveness
Authors: Stratton Elizabeth , Player Michael J. , Glozier Nick 
Published: February 2023

Abstract
Purpose
The emergence of digital health interventions for mental ill-health in the workplace is expansive. Digital interventions delivered in male-dominated settings are less so. This pilot study aimed to assess the usability, feasibility, acceptability, and preliminary effects of an online intervention in a male-dominated organization. We focus on male-dominated as mental ill-health is frequently unrecognized and underdiagnosed among males.

Methods
Unwind, a 7-week internet-based program with stress-management components, was tested in a pre-post pilot study. Unwind gets users to identify and understand their stress triggers and assists them to develop adaptive ways to manage these and their stress. Participants were Australian adults employed in a mining company. Follow-up assessment occurred 8 weeks after baseline. The primary outcome measure was change in stress symptoms, with secondary outcomes; change in depression, anxiety, insomnia, well-being, and alcohol use. User feedback and program data were analyzed to assess usability, engagement, and intervention adherence.

Results
Eligible participants n = 87 showed significant reductions in stress (g = 0.46, p < 0.001), depression (g = 0.47, p < 0.001), anxiety (g = 0.50, p < 0.001), insomnia (g = 0.44, p < 0.001), and well-being (g = 0.32, p = 0.004) post-intervention. Significant improvements were observed in both well and unwell (mental ill-health) and male and female participants. There was no gender effect on outcomes. A dose–response was observed as the number of modules used was related positively to improvement in anxiety (F1,86 = 5.735, p = 0.019; R2 = 0.25). Overall users rated Unwind as useful and engaging.

Conclusion
This study presents evidence base that Unwind is a feasible and acceptable approach to reducing employees’ mental health-related symptoms in typically difficult-to-reach male-dominated industries. Unwind is feasible for larger scale delivery within male-dominated industries.
Biased $$2 \times 2$$ periodic Aztec diamond and an elliptic curve
Authors: Borodin Alexei , Duits Maurice 
Published: February 2023

AbstractWe study random domino tilings of the Aztec diamond with a biased $$2 \times 2$$

2
×
2

periodic weight function and associate a linear flow on an elliptic curve to this model. Our main result is a double integral formula for the correlation kernel, in which the integrand is expressed in terms of this flow. For special choices of parameters the flow is periodic, and this allows us to perform a saddle point analysis for the correlation kernel. In these cases we compute the local correlations in the smooth disordered (or gaseous) region. The special example in which the flow has period six is worked out in more detail, and we show that in that case the boundary of the rough disordered region is an algebraic curve of degree eight.
Increased brick ratio in urban substrates has a marginal effect on tree saplings
Authors: Bauer Markus , Krause Martin , Heizinger Valentin , Kollmann Johannes 
Published: February 2023

AbstractFrom construction and demolition of buildings, brick wastes accumulate in large quantities and are difficult to recycle. Re-using bricks as planting substrate could partly substitute gravel or other raw materials, and would reduce deposition of bricks in landfills. High water-holding capacity and a high specific surface of such substrates are beneficial for plant growth, while high pH could be a disadvantage. This study focuses on potential effects of brick-based substrates on survival, growth and functional traits of two urban trees (Acer platanoides, Tilia cordata). We compared the effects of brick quantity (5 vs. 30%), pre-treatment with phosphoric acid, nutrient-poor vs. -rich soil, and mycorrhiza inoculation upon saplings in two greenhouse experiments. There were no effects on survival, while a high brick ratio slightly reduced growth of A. platanoides and its branching in nutrient-rich soil, and tend to increase the root-to-shoot ratio in both species. The acid pre-treatment caused negative effects on relative growth rate of A. platanoides. Mycorrhiza inoculation had a tendency for a positive effect on growth in T. cordata, but only with 5% brick ratio. Overall, the brick-based substrates have no clear effect on the study species. Thus, bricks can be recommended as a neutral component within constructed Technosols, and can be used to modify grain size distribution without negative effects on survival, growth and performance, while further studies are needed on bricks with cement and gypsum contaminations.
Screening for affective dysregulation in school-aged children: relationship with comprehensive measures of affective dysregulation and related mental disorders
Authors: Treier A.-K. , Döpfner M. , Ravens-Sieberer U. , Görtz-Dorten A. , Boecker M. , Goldbeck C. , Banaschewski T. , Aggensteiner P.-M. , Hanisch C. , Ritschel A. , Kölch M. , Daunke A. , Roessner V. , Kohls G. , Kaman A. ,   for the ADOPT Consortium, Aggensteiner Pascal-Maurice , Banaschewski Tobias , Bernheim Dorothee , Bienioschek Stefanie , Boecker Maren , Brandeis Daniel , Daunke Andrea , Döpfner Manfred , Fegert Jörg M. , Frenk Franziska , Giller Franziska , Ginsberg Claudia , Goldbeck Carolina , Görtz-Dorten Anja , Groh Monja , Hanisch Charlotte , Hellmich Martin , Hohmann Sarah , Holz Nathalie , Igel Christine , Junghänel Michaela , Kaiser Anna , Kaman Anne , Katmer-Amet Betül , Katzmann Josepha , Kölch Michael , Millenet Sabina , Mücke Kristina , Ravens-Sieberer Ulrike , Ritschel Anne , Roessner Veit , Schreiner Anne , Schroth Jennifer , Schüller Anne , Steiner Marie-Therese , Steiner Marion , Treier Anne-Katrin , Uhlmann Anne , Winkler Matthias , Zaplana Sara 
Published: February 2023

AbstractAffective dysregulation (AD) is characterized by irritability, severe temper outbursts, anger, and unpredictable mood swings, and is typically classified as a transdiagnostic entity. A reliable and valid measure is needed to adequately identify children at risk of AD. This study sought to validate a parent-rated screening questionnaire, which is part of the comprehensive Diagnostic Tool for Affective Dysregulation in Children (DADYS-Screen), by analyzing relationships with comprehensive measures of AD and related mental disorders in a community sample of children with and without AD. The sample comprised 1114 children aged 8–12 years and their parents. We used clinical, parent, and child ratings for our analyses. Across all raters, the DADYS-Screen showed large correlations with comprehensive measures of AD. As expected, correlations were stronger for measures of externalizing symptoms than for measures of internalizing symptoms. Moreover, we found negative associations with emotion regulation strategies and health-related quality of life. In receiver operating characteristic (ROC) analyses, the DADYS-Screen adequately identified children with AD and provided an optimal cut-off. We conclude that the DADYS-Screen appears to be a reliable and valid measure to identify school-aged children at risk of AD.
Laser acupuncture improving functional chronic constipation in children: a randomized controlled trial
Authors: Abd El Azeem Amany M. , Alsharnoubi Jehan , Abd El-Rahman Mohamed Marwa 
Published: February 2023

AbstractFunctional chronic constipation (FCC) is a disorder caused by low fiber consumption, lack of fluid intake, lack of mobility, or side effects of medications. The objective of this study was to compare the effects of laser acupuncture and the commonly used osmotic laxative, lactulose (as the control), both combined with behavioral therapy and dietary modification, on children with FCC in a randomized controlled trial (RCT). Forty children were randomly chosen, aged 5–15 years with FCC, and randomized into two equal groups (gender ratio (50% male; 50% female), mean ± SD weight (24.2 ± 6.27 kg and 25.7 ± 7.47 kg for groups A and B, respectively)). Study group (group A): used laser acupuncture (650 nm), 30 mW, 0.15 cm2 spot size, 90 s per acupuncture point (ST25, ST36, ST37, BL25, and LI11). Control group (group B): lactulose syrup (1 to 3 mL/kg/day) orally, in divided doses 3 times weekly for 4 weeks, and behavioral training for both groups. Evaluations were conducted before and after the study to assess the efficacy of the therapy. Median value frequency significantly increased in groups A and B post-treatment (4 (6.75–3) and 3 (3.75–2), respectively) compared to pre-treatment (2 (2–1) and 2 (2–0.25), respectively) (p = 0.0001), in favor of group A (p = 0.01). Significant improvement of stool consistency according to Bristol stool scale (BSS) in groups A and B (p = 0.0001), (p = 0.002) respectively in favor of group A (p = 0.03). T-test, Fisher, and Wilcoxon signed rank tests were conducted to compare groups. Non-invasive, painless laser acupuncture therapy can be considered as an alternative therapy for patients with FCC.
Comparative effects of biopesticides on fall armyworm management and larval parasitism rates in northern Ghana
Authors: Agboyi Lakpo Koku , Nboyine Jerry Asalma , Asamani Ebenezer , Beseh Patrick , Badii Benjamin K. , Kenis Marc , Babendreier Dirk 
Published: February 2023

AbstractThe outbreak of the fall armyworm, Spodoptera frugiperda, in Africa has led to several recommendations of insecticides, including biopesticides. However, the effects of these products on the environment, especially on parasitoids have not been assessed under field conditions. Here, we investigated the effect of commonly used biopesticides on S. frugiperda management and larval parasitoids of S. frugiperda in northern Ghana. The experiments were conducted both on-station in Wa and Nyankpala and on-farm in Wa during the 2020 rainy season. Active ingredients tested included neem oil (3% Azadirachtin), maltodextrin (282 g/l), 55% Bacillus thuringiensis (Bt) combined with 45% Monosultap, and a Pieris rapae granulosis virus combined with 5% Bt. A chemical insecticide based on emamectin benzoate and acetamiprid was used as positive control while non-treated maize plots were considered as untreated control. The two most abundant parasitoids in Wa were Coccygidium luteum and Chelonus bifoveolatus, while in Nyankpala they were C. luteum and Meteorus sp. Total larval parasitism rates on-station were 18.7% and 17.6% in Wa and Nyankpala, respectively, and 8.8% in Wa on-farm. Parasitoid species diversity and evenness indexes did not vary among treatments, but parasitism rates were significantly lower with the chemical on-station in Wa and with the virus and Bt product in Nyankpala. Untreated maize plots showed the highest larval density and plant damage, the highest cob damage, and generated the lowest yields. The other treatments showed hardly any difference in cob damage and yields, suggesting that biopesticides should be preferred over chemical pesticides for S. frugiperda control.
Zur Vereinbarkeit von vorzeitigem Baubeginn und Naturschutz: Zwischen realpolitischer Hektik und rechtsstaatlichen Grundsätzen
Authors: Roth Maximilian 
Published: February 2023

ZusammenfassungDer vorzeitige Baubeginn ist in etlichen Fachplanungsrechten seit geraumer Zeit normiert, gewinnt
aber erst in der jüngeren Vergangenheit eine deutlich wahrnehmbare und auch mediale Beachtung. Nach
einer Einführung in das Instrument des vorzeitigen Baubeginns (1.) sollen drei aktuelle Beispiele
vorgestellt (2.), ehe die Tatbestandsmerkmale (3.) auf deren Einschlag in naturschutzrechtliche Belange
(4.) untersucht und hinsichtlich der drei Beispiele kritisch reflektiert werden. Ein Abriss über
rechtsstaatliche Grundsätze (5.) und ihre Geltung auch in Zeiten realpolitischer Hektik (6.) runden
den Beitrag mit einem Ausblick (7.) ab.