bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ixekizumab-Induced Urticarial Drug Eruption
Authors: Kaneoka Ayaka , Saito-Sasaki Natsuko , Okada Etsuko , Sawada Yu 
Published: July 2023

Abstract
Biological agents targeting inflammatory skin diseases have dramatically overcome many of the limitations of older oral therapeutic options. Among the various biological agents, ixekizumab is a humanised monoclonal antibody that blocks the biological activity of IL-17A, which exhibited high efficacy against psoriasis. Although there are a limited number of cutaneous adverse reactions, biologic-induced type I allergic reactions are rare. Herein, we report a case of ixekizumab-induced urticaria.
Association between trajectories of maternal depressive symptoms and length of hospital stay, hospitalization costs, and adverse maternal and infantile outcomes: A longitudinal observational study
Authors: Sun Jiwei , Cui Naixue , Shao Di , Li Jie , Zhang Huihui , Li Jiahuan , Zhang Xuan , Cao Fenglin 
Published: July 2023

AbstractThis study aimed to determine the trajectories of perinatal depression and their relationship with length of hospital stay (LOS), hospitalization costs, and adverse maternal and infantile outcomes. This longitudinal observational study included 525 participants. Perinatal depressive symptoms were assessed at four waves (from the first trimester to the postpartum period). LOS, hospitalization costs, and adverse maternal (sleep, fatigue, anxiety, perceived stress, and memory problems) and infantile outcomes of participants were obtained from medical records and self‐reported questionnaires. Trajectories of perinatal depressive symptoms were explored with latent class growth analysis. Associations between trajectories and adverse maternal and infant outcomes were explored with multiple linear regression and binary logistic regression models. The participants' average age was 29.6 ± 3.9 years. Five heterogeneous developmental trajectories of perinatal depressive symptoms were identified as follows: high‐level (7.05%), moderate‐increasing (12%), remission (15.05%), moderate‐level (37.14%), and low‐level (28.76%). The average LOS was 5.78 ± 2.13 days, and the average hospitalization costs were 12,695.27 ± 5457.51 yuan. Compared with the trajectory of low‐level depressive symptoms, the LOS, hospitalization costs, and likelihood of adverse outcomes of women with high‐level and moderate‐increasing depressive symptom trajectories increased. The findings capture the heterogeneity of perinatal depression in Chinese women. Women in the moderate‐increasing and high‐level trajectory groups had longer LOS, more hospitalization costs, and poor birth outcomes. Elucidating the trajectories of perinatal depression and their relationship with maternal and infant health outcomes provides important insights into the development of person‐centred care planning for women during pregnancy and postpartum.
The Application of Engineered Nanomaterials in Perinatal Therapeutics
Authors: Stapleton Phoebe A. 
Published: July 2023

AbstractPregnancy is a vulnerable life stage for the mother and developing fetus. Because of this dual concern, approved therapeutic options for pre‐existing conditions or pregnancy‐induced pathologies, placental deformities, or fetal concerns are extremely limited. These cases often leave patients and clinicians having to choose between maternal health and fetal development. Recent advancements in nanomedicine and nanotherapeutic devices have made the development of perinatal therapeutics an attractive objective. However, perinatal medicine requires a multifaceted approach given the interactions between maternal, placental, and fetal physiology. Maternal–fetal interactions are centralized to the placenta, a specialized transient barrier organ, to allow for nutrient and waste exchange. Perinatal nanotherapeutics must be designed for placental avoidance or uptake. In this review, pregnancy‐related conditions, experimental models, and modes of drug delivery during pregnancy are discussed.
Impedance‐Based Multimodal Electrical‐Mechanical Intrinsic Flow Cytometry
Authors: Feng Yongxiang , Zhu Junwen , Chai Huichao , He Weihua , Huang Liang , Wang Wenhui 
Published: July 2023

AbstractReflecting various physiological states and phenotypes of single cells, intrinsic biophysical characteristics (e.g., mechanical and electrical properties) are reliable and important, label‐free biomarkers for characterizing single cells. However, single‐modal mechanical or electrical properties alone are not specific enough to characterize single cells accurately, and it has been long and challenging to couple the conventionally image‐based mechanical characterization and impedance‐based electrical characterization. In this work, the spatial‐temporal characteristics of impedance sensing signal are leveraged, and an impedance‐based multimodal electrical‐mechanical flow cytometry framework for on‐the‐fly high‐dimensional intrinsic measurement is proposed, that is, Young's modulus E, fluidity β, radius r, cytoplasm conductivity σi, and specific membrane capacitance Csm, of single cells. With multimodal high‐dimensional characterization, the electrical‐mechanical flow cytometry can better reveal the difference in cell types, demonstrated by the experimental results with three types of cancer cells (HepG2, MCF‐7, and MDA‐MB‐468) with 93.4% classification accuracy and pharmacological perturbations of the cytoskeleton (fixed and Cytochalasin B treated cells) with 95.1% classification accuracy. It is envisioned that multimodal electrical‐mechanical flow cytometry provides a new perspective for accurate label‐free single‐cell intrinsic characterization.
Use of road infrastructure for movement by common terrestrial vertebrates
Authors: Charles Felicity E. , Brady Megan J. , Smith Annabel L. 
Published: July 2023

AbstractWildlife‐vehicle collisions are increasing with road expansion. This problem could be minimised if the use of existing infrastructure to cross roads could be enhanced. We aimed to determine whether common terrestrial vertebrates used drainage culverts to cross roads, relative to rates of surface crossings. Camera traps were deployed on road verges at 30 locations in southeast Queensland, Australia for 2 weeks each over a 3‐month period. Of 1671 independent animal observations, 397 were direct observations of road crossings, either over‐road (365) or under‐road via culverts (32). Native species and small species were found more commonly at roadsides than culverts and where vegetation density was lower. Our data showed that animals used culverts only about 6% of the time. Management such as funnel fencing or vegetation manipulation could encourage wildlife to use culverts, but this would require a substantial investment given the propensity for animals to cross via the road surface.
Wort für Wort. Bedingungen der Analyse diplomatischer Wortprotokolle als historische Quellen
Authors: Weichselbraun Anna 
Published: July 2023

ZusammenfassungIn diesem Kapitel untersuche ich Eignung und Grenzen des »Protokolls« als historische Quelle. Protokolle sind nicht nur das »gefilterte Gedächtnis« einer Organisation, sondern werden auch zu historischen Quellen für WissenschaftlerInnen, die dieses gefilterte Gedächtnis verstehen wollen. Wortwörtliche Aufzeichnungen oder Protokolle werden manchmal als Quelle bevorzugt, weil man davon ausgeht, dass sie vollständiger sind und somit das Ereignis akkurat repräsentiert wird. Entgegen dieser Annahme werde ich zeigen, dass sogar das Wortprotokoll eine stark stilisierte und veränderte Aufzeichnung des Ereignisses ist. Ich argumentiere, dass eine »verbatim ideology« (Inoue 2018) das Protokoll als genaue Quelle motiviert. Und schließlich, dass das Lesen des Wortprotokolls auf die entstehende Interaktionsdynamik des Ereignisses überraschende Einblicke in eingefahrene Diskussionen bieten kann.
»…für die aufmerksamen Zuhörer eine Pein, für die unaufmerksamen ein Schlafmittel«. Protokolle, Unmittelbarkeit und Wahrheitsfindung im Disziplinarakt öffentlich Bediensteter
Authors: Garstenauer Therese 
Published: July 2023

ZusammenfassungDas Protokoll schreibt institutionell produzierte Wahrheit fest, verbürgt durch formale Vorgaben seiner Entstehung sowie die Kopräsenz der oder des Protokollierenden zum Ereignis. In diesem Beitrag wird erörtert, welche Rolle Protokolle in Disziplinarverfahren von öffentlich Bediensteten des frühen 20. Jahrhunderts spielten. Zunächst werden Ähnlichkeiten und Unterschiede zwischen den Gerichts- und Disziplinarverfahren erfasst, zumal das Disziplinarrecht ab 1914 auf Basis der Strafprozessordnung von 1873 modelliert wurde. Eine zentrale Frage ist, wie mit Protokollen aus Vorerhebungen im Prozess umgegangen wird – sollen sie in der mündlichen Verhandlung verlesen werden oder soll die befragte Person persönlich aussagen? Zudem braucht es für die Wahrheitsfindung mitunter mehr als protokollarisch festgehaltene sprachliche Äußerungen: auch Pläne, Gutachten und der »Augenschein« werden erfasst. Am Beispiel des Disziplinarfalls eines niederösterreichischen Bezirksbeamten aus den 1920ern, der eine Entscheidung des Verfassungsgerichtshofs unflätig verunglimpft haben soll, wird gezeigt, mit welchen Mitteln hier eine Wahrheit produziert wurde, die eine Entscheidung in der Disziplinarsache erlaubte.
Mean Ergodic Weighted Shifts on Köthe Echelon Spaces
Authors: Kalmes Thomas , Santacreu Daniel 
Published: July 2023

AbstractNecessary and sufficient conditions are given for mean ergodicity, power boundedness, and topologizability for weighted backward shift and weighted forward shift operators, respectively, on Köthe echelon spaces in terms of the weight sequence and the Köthe matrix. These conditions are evaluated for the special case of power series spaces which allow for a characterization of said properties in many cases. In order to demonstrate the applicability of our conditions, we study the above properties for several classical operators on certain function spaces.
Homoeologous non-reciprocal translocation explains a major QTL for seed lignin content in oilseed rape (Brassica napus L.)
Authors: Schilbert Hanna Marie , Holzenkamp Karin , Viehöver Prisca , Holtgräwe Daniela , Möllers Christian 
Published: July 2023

Abstract
Key message
A homoeologous non-reciprocal translocation was identified in the major QTL for seed lignin content in the low lignin line SGDH14. The lignin biosynthetic gene PAL4 was deleted.

Abstract
Oilseed rape is a major oil crop and a valuable protein source for animal and human nutrition. Lignin is a non-digestible, major component of the seed coat with negative effect on sensory quality, bioavailability and usage of oilseed rape’s protein. Hence, seed lignin reduction is of economic and nutritional importance. In this study, the major QTL for reduced lignin content found on chromosome C05 in the DH population SGDH14 x Express 617 was further examined. SGDH14 had lower seed lignin content than Express 617. Harvested seeds from a F2 population of the same cross were additionally field tested and used for seed quality analysis. The F2 population showed a bimodal distribution for seed lignin content. F2 plants with low lignin content had thinner seed coats compared to high lignin lines. Both groups showed a dark seed colour with a slightly lighter colour in the low lignin group indicating that a low lignin content is not necessarily associated with yellow seed colour. Mapping of genomic long-reads from SGDH14 against the Express 617 genome assembly revealed a homoeologous non-reciprocal translocation (HNRT) in the confidence interval of the major QTL for lignin content. A homologous A05 region is duplicated and replaced the C05 region in SGDH14. As consequence several genes located in the C05 region were lost in SGDH14. Thus, a HNRT was identified in the major QTL region for reduced lignin content in the low lignin line SGDH14. The most promising candidate gene related to lignin biosynthesis on C05, PAL4, was deleted.
Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro
Authors: Manandhar Bikash , Paudel Keshav Raj , Clarence Dvya Delilaa , De Rubis Gabriele , Madheswaran Thiagarajan , Panneerselvam Jithendra , Zacconi Flavia C. , Williams Kylie A. , Pont Lisa G. , Warkiani Majid Ebrahimi , MacLoughlin Ronan , Oliver Brian Gregory , Gupta Gaurav , Singh Sachin Kumar , Chellappan Dinesh Kumar , Hansbro Philip M. , Dua Kamal 
Published: July 2023

AbstractLung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Zerumbone (ZER) is natural compound commonly found in the roots ofZingiber zerumbetwhich has recently demonstrated anti-cancer activity in both in vitro and in vivo studies. Despite their medical benefits, ZER has low aqueous solubility, poor GI absorption and oral bioavailability that hinders its effectiveness. Liquid crystalline nanoparticles (LCNs) are novel drug delivery carrier that have tuneable characteristics to enhance and ease the delivery of bioactive compounds. This study aimed to formulate ZER-loaded LCNs and investigate their effectiveness against NSCLC in vitro using A549 lung cancer cells. ZER-LCNs, prepared in the study, inhibited the proliferation and migration of A549 cells. These inhibitory effects were superior to the effects of ZER alone at a concentration 10 times lower than that of free ZER, demonstrating a potent anti-cancer activity of ZER-LCNs. The underlying mechanisms of the anti-cancer effects by ZER-LCNs were associated with the transcriptional regulation of tumor suppressor genesP53andPTEN, and metastasis-associated geneKRT18. The protein array data showed downregulation of several proliferation associated proteins such as AXL, HER1, PGRN, and BIRC5 and metastasis-associated proteins such as DKK1, CAPG, CTSS, CTSB, CTSD, and PLAU. This study provides evidence of potential for increasing the potency and effectiveness of ZER with LCN formulation and developing ZER-LCNs as a treatment strategy for mitigation and treatment of NSCLC.
The application of chitosan as an eco-filler of polymeric composites
Authors: Fila Karolina , Podkościelna Beata , Szymczyk Katarzyna 
Published: July 2023

AbstractThe aim of the study was the synthesis of polymer biocomposites based on acrylates with the addition of various amounts of chitosan as an eco-filler. The composites (BPA.DA + NVP) were prepared using the photopolymerization technique. The obtained materials were subjected to physicochemical tests, determining, among others, their hardness and thermal properties by the DSC and TG/DTG methods. The ATR/FT-IR analysis and optical profilometer as well as the values of the solid surface tension calculated from the contact angle of model liquids and van Oss et al. approach to the solid-liquid interface tension were performed to confirm the chemical structure of the obtained biocomposites.
National Surveillance of Home-Based HIV Testing Among Australian Gay and Bisexual Men, 2018–2020: Uptake After Commercial Availability of HIV Self-Tests
Authors: Zhang Ye , Holt Martin , Chan Curtis , Applegate Tanya L. , Bavinton Benjamin R. , Broady Timothy R. , Keen Phillip , Wulandari Luh Putu Lila , Mao Limin , McManus Hamish , Medland Nicholas A. , Prestage Garrett , Wiseman Virginia , Guy Rebecca J. 
Published: July 2023

AbstractHIV self-testing allows people to collect samples and test themselves at home, addressing known barriers to facility-based testing. We aimed to measure the uptake of home HIV testing among Australian gay and bisexual men (GBM). Using national cross-sectional data from the Australian Gay Community Periodic Surveys, we assessed trends in home HIV testing among non-HIV positive GBM between 2018 and 2020. Overall, the use of home HIV testing was low, but slightly increased during 2018–2020 (from 0.3 to 0.8%, RR = 1.54, 95%CI = 1.23–1.92, p-trend < 0.001). Testing at home was more likely among non-HIV-positive GBM who were born overseas and recently arrived in Australia, at higher risk of HIV, and infrequent HIV testers. Given the greater use of home testing by men at higher risk of HIV, recent migrants and infrequent testers, all priority groups in Australia’s HIV epidemic, we recommend increasing access to HIV self-testing to enhance uptake in these and other groups of GBM.
How Can Social Workers Assess Clinically Meaningful Change in Their Clients? An Example from Children in Care
Authors: Baviskar Siddhartha , Bergström Martin 
Published: July 2023

AbstractSocial workers use interventions in the expectation that they will make a positive difference for their clients. However, research about the effectiveness of interventions is typically presented at the group level, which places great demands on social workers’ ability to apply such results to the needs of individual clients. Further, the content and effects of “service as usual” (SAU) interventions that social workers typically offer are often not known, making it difficult for social workers to identify what aspects of the intervention any client change can be attributed to. Using indicators of clinically meaningful change (CMC) strengthens social workers’ ability to identify what, if anything, works in any given intervention for their individual clients, and also motivates their curiosity to identify the efficacious components of SAU. CMC refers to changes in an individual’s outcome measures that are reliable or are large enough to be considered “important.” We present five indicators to analyze CMC in a child’s psychological well-being measured with the Strengths and Difficulties Questionnaire and illustrate their use with two empirical examples from the project Me and My Foster Family. The examples demonstrated that conclusions regarding CMC can vary depending on the indicator used, the baseline assessment, and the magnitude of raw-score change on the measured outcome. To assess change at the individual level it is important to address questions of measurement reliability and the yardstick for judging when a change is large enough to be considered “important.” Implications for research and practice are discussed.
Mentalizing Capacity Partially Mediates the Relationship Between Attachment and Stress, Depression, and Anxiety in Social Work Students
Authors: Jansen Niels , Kühl Joana , Eller Natalie , Kingdon Phil , Firk Christine 
Published: July 2023

AbstractSocial work students experience high levels of stress, which makes them vulnerable to stress-related disorders such as depression. Attachment security has been associated with better stress regulation. Another factor that is closely associated with attachment is mentalization, i.e., the ability to reflect about one's own and others’ mental states, which may also influence the way people cope with stress. The main aim of the study was to investigate the impact of attachment and mentalization on stress, depression, and anxiety in social work students. 460 social work students completed the short version of the "Experiences in Close Relationships-Revised questionnaire” (ECR-RD8), “Relationship Questionnaire” (RQ-2), “Certainty About Mental States Questionnaire” (CAMSQ), “Perceived Stress Scale” (PSS-10) as well as the “Patient Health Questionnaire” (PHQ-9) and the “Generalized Anxiety Disorder Scale” (GAD-7) in a cross-sectional research design. The majority of the current social work students (71.1%) were assigned to an insecure attachment style and reported noticeably high levels of stress, depression, and anxiety. Insecurely attached students showed even higher levels of stress, depression, and anxiety compared to securely attached students. Moreover, the results indicate that securely attached students have better mentalizing skills and that mentalizing skills (partially) mediated the effect of attachment security on perceived stress, depression, and anxiety. Due to the importance of mentalization for stress regulation, mental health, and the quality of relationships, programs promoting mentalization in social work students should be implemented in social work education programs.
Ericksen-Landau Modular Strain Energies for Reconstructive Phase Transformations in 2D Crystals
Authors: Arbib Edoardo , Biscari Paolo , Patriarca Clara , Zanzotto Giovanni 
Published: July 2023

AbstractBy using modular functions on the upper complex half-plane, we study a class of strain energies for crystalline materials whose global invariance originates from the full symmetry group of the underlying lattice. This follows Ericksen’s suggestion which aimed at extending the Landau-type theories to encompass the behavior of crystals undergoing structural phase transformation, with twinning, microstructure formation, and possibly associated plasticity effects. Here we investigate such Ericksen-Landau strain energies for the modelling of reconstructive transformations, focusing on the prototypical case of the square-hexagonal phase change in 2D crystals. We study the bifurcation and valley-floor network of these potentials, and use one in the simulation of a quasi-static shearing test. We observe typical effects associated with the micro-mechanics of phase transformation in crystals, in particular, the bursty progress of the structural phase change, characterized by intermittent stress-relaxation through microstructure formation, mediated, in this reconstructive case, by defect nucleation and movement in the lattice.
Nutrient composition of common fish species in the Okavango Delta: potential contribution to nutrition security
Authors: Mogobe Oarabile , Mazrui Nashaat M. , Gondwe Mangaliso J. , Mosepele Ketlhatlogile , Masamba Wellington R. L. 
Published: July 2023

AbstractFish can be a key strategy in addressing the global food and nutrition insecurity challenges. Fish nutrient data are critical for policy development targeting to reduce these problems. Despite this, much of the published studies on nutritional characteristics of fish have focused on marine ecology and there is little information on natural freshwater fish habitats like inland delta areas. This study investigated the nutrient composition of Okavango Delta fishes and their potential contribution to the recommended nutrient intake. Fish species sampled were Clarias ngamensis, Oreochromis andersonii, Schilbe intermedius, Marcusenius altisambesi, Brycinus lateralis, Barbus poechii and Tilapia sparrmanii. The nutrients analyzed were moisture, ash, proteins, Na, K, Ca, Mg, P and Zn. The small fishes (B. lateralis and B. poechii) had higher mineral content; Ca (643–968 mg/100 g), Mg (47–49 mg/100 g) and Zn (2.8–3.6 mg/100 g) compared to the larger species with average mineral content; Ca (73–460 mg/100 g), Mg (23–35 mg/100 g), Zn (1.2–2.9 mg/100 g). The most nutrient-dense species recognized were B. poechii and B. lateralis followed by the large species, M. altisambesi. These species illustrated the potential to contribute 80–121% Ca, 32–47% Mg and 70–150% Zn of the recommended nutrient intake to children (1–9 years), pregnant women and the elderly (65 + years). The study recommends prioritizing small and some large species (M. altisambesi and T. sparrmanii) for polyculture systems, primarily for securing food and nutrition security for local communities.