bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlled Release Technologies for Chronotherapy: Current Status and Future
Perspectives
Authors: Bhat Bhavana B. , Mehta Chetan H. , Suresh Akhil , Velagacherla Varalakshmi , Nayak Usha Y. 
Published: May 2023

Abstract:
The expression “as sure as night follows a day” emulates those certain cycles in the environment that
are always stable. Circadian rhythms are a group of processes that occur within the body in synchronisation
with the external factors in a 24 h cycle. Changes in lifestyle and work shifts have disrupted these stable
rhythms, which is a leading cause of lifestyle diseases. Associations between these biological clocks and diseases
are abundant. However, it is also known that certain drugs work more efficiently and have minimum toxicity
when given during a particular phase of the circadian cycle. Chronotherapeutics focuses on treating diseases
according to the endogenous processes which mediate xenobiotic metabolism and drug response at a cellular
level. Therefore, treatment of those diseases that show aggravation of symptoms according to the circadian
rhythms at a particular time is highly beneficial by chronotherapy. In this article, we have emphasised how the
changes in rhythms caused diseases and how chronotherapeutic approaches such as controlled drug release
technologies can be a better option for these circadian manipulations that seem to influence all types of disease
conditions.
miR-141-3p Enhanced Radiosensitivity of CRC Cells
Authors: Peng Lizhong , Li Pan , Peng Zexu 
Published: May 2023

Background:
Colorectal cancer (CRC) is recognized as one of the frequently diagnosed
malignancies, and numerous microRNAs (miRs) are identified to be active in CRC.

Objective:
This work aimed to clarify the effect of miR-141-3p on the radiosensitivity of CRC
cells.

Methods:
Firstly, CRC cell lines were cultured and applied to construct radiation-resistant CRC
cells via X-ray treatment. The expression levels of miR-141-3p and long non-coding RNA DLX6
antisense RNA 1 (lncRNA DLX6-AS1) in CRC cells were measured using real-time quantitative
polymerase chain reaction. After transfection with miR-141-3p mimics and 24 h treatment with 6-
MV X-ray (0, 2, 4, 6 Gy), the survival fraction (SF) and the colony formation ability of CRC cells
were determined using the cell counting kit-8 and colony formation methods. The interactions between
miR-141-3p and DLX6-AS1 were analyzed using the dual-luciferase assay. The impact of
miR-141-3p on DLX6-AS1 stability was detected after adding actinomycin-D. The role of DLX6-
AS1 in the radiosensitivity of CRC cells was explored by transfecting oe-DLX6-AS1 into radiation-
resistant CRC cells overexpressing miR-141-3p.

Results:
The relative expression levels of miR-141-3p were downregulated in CRC cells and further
declined in radiation-resistant cells. Upregulation of miR-141-3p relative expression reduced
SF and the colony formation ability while amplifying the radiosensitivity of radiation-resistant
CRC cells. miR-141-3p directly bound to DLX6-AS1 to reduce DLX6-AS1 stability, and therefore
downregulated DLX6-AS1 expression. DLX6-AS1 overexpression counteracted the role of miR-
141-3p overexpression in amplifying the radiosensitivity of radiation-resistant CRC cells.

Conclusion:
miR-141-3p binding to DLX6-AS1 significantly decreased DLX6-AS1 stability and
expression, promoting the radiosensitivity of CRC cells.
A Mini-review on New Developments in Nanocarriers and Polymers for
Ophthalmic Drug Delivery Strategies
Authors: Sharma Yash , Patel Preeti , Kurmi Balak Das 
Published: May 2023

Abstract:
The eye is an important and vital organ of the human body consisting of two segments - anterior
and posterior segments and these segments are associated with many diseases. This review elaborates
upon the various eye-related diseases with their medications and carriers used to deliver them.
Delivery strategies include drugs encapsulated into liposomes, polymeric micelles of drugs, solid lipid
nanoparticles, nanostructured lipid carriers, nano emulsions, and Nanosuspension used to improve penetrating
properties, bioavailability, and residence time of the drugs as examples available in the literature.
With regard to this, different forms of ocular drug delivery are classified and elaborated. Additionally,
the possibility of addressing the physical and chemical complexities of ocular diseases and how they
could be overcome with environmentally stable nanoformulations are briefly discussed. Enhanced drug
delivery efficiency with various novel pharmaceuticals along with enhanced uptake by different
routes/modes of drug administration. Current advancements in drug carrier systems, i.e., nanocarriers,
have shown promise for improving the retention time, drug permeation and prolonging the duration of
release of the drug in the ocular site. Bio-degradable polymers investigated for the preparation of
nanocarriers for the entrapment of drugs and to enhance the efficacy through improved adherence of
tissue in the eye, sustained release measures, enhanced bioavailability, lower toxicity, and targeted delivery
is applicable. This review covers the introduction of various nanocarriers and polymers for ocular
drug delivery with the purpose of enhancing the absorption, retention and bioavailability of medications
in the eye.
Prevalence of diabetes mellitus among newly detected sputum positive pulmonary tuberculosis patients and associated risk factors: A cross-sectional study
Authors: Motappa Rohith , Hullalli Rashmi , Gudadinni  
Published: May 2023

Background:
Tuberculosis (TB) and diabetes mellitus (DM) co-morbidity is one of the rising public health problems. There is growing evidence that DM is an important risk factor for TB. This study was carried out to determine the prevalence of DM among newly detected sputum-positive pulmonary TB patients registered in the District Tuberculosis Centre and to assess the risk factors of DM among TB patients.

Methods:
In a cross-sectional study, newly detected sputum-positive pulmonary TB patients were screened for DM (those having symptoms of DM). Furthermore, they were diagnosed by detecting blood glucose levels (≥200 mg/dL). Mean, standard deviation (SD), Chi-squared, and Fisher-Freeman-Halton exact tests were used to determine the significant associations. P-values less than 0.05 were considered to be statistically significant.

Results:
A total of 215 TB patients were included in this study. The prevalence of DM among TB patients was found to be 23.7% (2.8% known and 97.2% new cases). Significant associations were found between age (>46 years old), educational status, smoking habits, alcohol consumption, and physical activity.

Conclusion:
Routine screening for DM is mandatory due to its increasing prevalence, which may help in early diagnosis and reduce complications by proper management, in turn helping in the successful outcome of TB treatment.
Chemical Constituents from the Roots of Jasminum sambac (L.) Ait. and their Cytotoxicity
to the Cancer Cell Lines
Authors: Olatunde Olagoke Zacchaeus , Yong Jianping , Lu Canzhong 
Published: May 2023

Background:
The roots of J. sambac is the Traditional Chinese Medicine (TCM) with analgesic and anesthetic
effects. However, relatively fewer studies on the chemical compositions and the biological activities of the roots
of J. sambac have been carried out till now. We studied the chemical compositions of the roots of J. sambac planted in
Fujian Province to discover new compounds from this TCM to develop new drugs or drug candidates.

Aim:
This work aims to find the new compounds from the roots of Jasminum sambac (L.) Ait. (J. sambac) for the
development of new drugs or drug candidates.

Methods:
The dichloromethane (DCM) extract was selected to isolate over silica gel column chromatography to obtain
different polar fractions. Several similar fractions were combined according to Thin Layer Chemotherapy (TLC) or
High-Performance Liquid Chromatography (HPLC) analysis. The combined fractions were reisolated by silica gel
column chromatography, preparative TLC or HPLC to obtain nine pure compounds (1-9). The purity of the isolated
compounds was detected by HPLC, and their structures were determined by 1D, 2D NMR, and HRESIMS analysis.
The in vitro anticancer activity was evaluated using Cell Counting Kit-8 (CCK8) method.

Results:
Nine compounds were isolated in this work. Compounds (1-3) are new compounds, while compounds (4-9)
were isolated for the first time from the roots of J. sambac. Their structures were elucidated by 1D, 2D NMR, and
HRESIMS analysis. The biological evaluation showed that compound 7 exhibited potent cytotoxic efficacy against
MCF-7 cell lines with IC50 values of 148.3 μM for 24 hs and 35.94 μM for 48 hs, respectively; compound 1 displayed
significant cytotoxic potential against MCF-7 cell lines with IC50 value of 38.5 μM for 24 hs; while compound 3 and 4
displayed potent cytotoxic effects against MCF-7 cell lines with IC50 values of 161.1 μM and 243.7 μM for 48 hs,
respectively.

Conclusion:
We discovered new compounds from the roots of J. sambac. and several compounds exhibited potent
cytotoxity to MCF-7 cell lines. This work encourages us to further study the chemical constituents and their biological
activities from the roots of J. sambac.
TO STUDY THE AWARENESS OF HEALTH AMONGST SECONDARY STANDARD STUDENT
Authors: Dhaigude Anita Kumar 
Published: May 2023

Now a days, teenagers or adolescents have change in comparison with the teens in past, taking into account their eating habits, an active way of life, spending free time and clothes. They are a “technology” generation .Every teenager needs a balance diet, appropriate personal hygiene and physical activities in fresh air eg: walking, cycling, jogging, swimming etc. They find gadgets like computers, smart phones, tabs, note pads etc. more interesting than these physical activities. All in all it can be stated that today’s teen	life is more complex depending on various factors. But out of this Nutrition, Physical activity and sleep plays a very important role in their health.
Importância financeira da proximidade geográfica das usinas sucroenergéticas aos centros de tecnologia-inovação no Brasil
Authors: Aparecida Segecic Bruna , Veloso Conceição Elimar , Basso Montoro Stela , Ferreira Lopes Santos David 
Published: May 2023

A indústria sucroenergética brasileira tem sua competitividade baseada em inovação que permite produzir alimento, biocombustível e bioenergia. Todavia, o desempenho financeiro é assimétrico entre as usinas cujas estratégias de inovação são heterogêneas. Este estudo objetiva verificar se as usinas sucroenergéticas localizadas estrategicamente próximas aos Centros de Tecnologia e Inovação apresentam desempenho financeiro superior àquelas mais distantes. Utilizou-se dados financeiros anuais de 56 usinas de 1998 a 2018, extraídos de bases de dados públicas e privadas. Para comparar as médias dos resultados financeiros empregou o Teste-t. As usinas mais próximas aos Centros apresentaram desempenho financeiro estatisticamente superior àquelas mais afastadas.
Small business in construction: new products and new markets
Authors: Yas’kova Natal’ya , Kolomijec Anna , Pivovarov Boris 
Published: May 2023

The problem of getting out of an economic recession is equally relevant not only for all countries without exception, but also for all segments of national economies. Analysis of the response of small and medium-sized businesses, as well as individual entrepreneurship, showed that this is perhaps the most affected segment of the national economy from the coronavirus crisis. At the same time, the study showed that the recovery potential of the economy significantly depends on the degree of development and scale of small business. And if the pattern of achieving sustainability in overcoming crisis shocks identified by the authors is higher, the lower the share of SMEs in the global economy, the lower the share of SMEs in the global economy, the higher the share of SMEs in GDP, the more successful recovery growth is.
Unlike developed countries, Russia has a three-fold lower share of SMEs in GDP, but a significantly higher volatility of the shadow economy. Preventive measures that prevent the expansion of the latter and support small businesses have not been able to stop the bankruptcy of small and medium-sized enterprises and have not yet led to the desired results in terms of the recovery rate of business and investment activity in the small business segment. Their effectiveness is assessed by the business as insignificant. At the same time, from the authors point of view, not only inclusive incentive and supportive measures can cope with the recession of the small business segment. It is important to find drivers of development in the specified segment. They are the ones who will be able to give an impetus to development at the high level of economic efficiency maintained during the crisis.
In the context of the search for economic clusters that need construction services and have proven their ability to implement investment and construction projects in a cost-effective manner, the authors identified eight starting types: creative economy, innovative economy, green economy, health and sports economy, festival and farm economy, and service economy of small towns and settlements. Targeted focus of government support measures for these segments can become a real trigger for the development of SMEs.
Assessment of the project management system in the context of the implementation of large–scale projects: approaches and indicators
Authors: Simionova Nina , Simionov Radomir , Sinyak Nikolay 
Published: May 2023

A constant search for effective management tools becomes necessary against the background of economic globalization, growing competition, fast changing environmental factors, increasingly stringent product quality requirements. The project management methodology can boost management efficiency by focusing efforts on a specific area of activity and implementing the necessary strategic changes. As management problems become more complicated, the project management system itself undergoes changes and moves to a new level of organizational maturity, but the process of these changes cannot be considered complete. It is necessary to use performance indicators to boost the motivation of a project team.
The research shows that it is necessary to improve the tools used to assess in-house project management systems that rely on the international experience of using both the key indicators and expert assessments that entail a comparison with a certain reference state of the system. The system of indicators should have an integrated management framework designed in the format of a project-oriented structure.
The purpose of the article is to consider and generalize the approaches, goals and principles of a system of indicators for assessing project management in an organization and drafting a system of indicators. The coauthors take advantage of the provisions of the project management methodology and framework management models to develop a system of indicators used to assess project management processes and results. Their novelty stems from an approach to the systematization of indicators in the context of subject- and management-focused process groups, specified in the Russian project management standards with a focus on the function of control.
“Timeback” concept — the future of the comfortable urban environment
Authors: El-Hashem Aiman , Fedulova Nina Sergeevna , Beliakov Sergey Igorevich 
Published: May 2023

In modern urban life, especially in large cities and megapolises, the principle of time-saving for residents is becoming increasingly important. Residents should be able to get to work, studies, shops and other places where they spend their time quickly and conveniently. In current Russian practice, this principle is most widely applied in the updated concept of urban space development implemented by the Samolet Group — the company's innovative approach is implemented in the “timeback” concept, which provides methodological connection of all elements and directions of development within the target vector of sustainable territorial development. The analysis of competitiveness factors in the context of introducing the “timeback” concept into development practice leads to the conclusion that the introduction of the concept can improve the quality of housing and the level of service, as well as more efficient use of investment potential of the territory and solve the marketing tasks and product promotion. In the medium and long-term aspects, a comprehensive introduction of the “timeback” concept within the company's project portfolio can contribute to the formation of a positive reputation of the developer, its long-term competitiveness, and positively influence the regional market as a whole, contributing to improvement of the product quality and competition.
Debt Analyst Coverage of Private Firms
Authors: Gillette Jacquelyn R. 
Published: May 2023

ABSTRACT
This study examines how information spillovers from equity to debt markets (“equity spillovers”) affect sell-side debt analysts’ activities and the informativeness of their reports. To explore this relation, I compare debt analyst reports for firms without equity spillovers (private firms) to firms with equity spillovers (public firms). I find that, absent equity spillovers, analysts rely more on mandatory SEC filings to fill the information gap for private firms. This additional effort, however, reduces debt analysts’ coverage of private firms overall. Conditional on coverage, the content of debt analyst reports is remarkably similar across private and public firms. Finally, I find that debt analyst reports are more informative for private firms than for public firms. Collectively, my findings shed light on the externalities created by equity spillovers and how debt market intermediaries contribute to the price discovery process.
PEMBINAAN SPRITUAL CINTA KASIH YESUS KRITUS PADA TNI ANGKATAN DARAT
Authors: Riyanto Agustinus , Helanuswa Albertus Ganadri 
Published: May 2023

The Indonesian Republic Army have several jobs that require them to work on the front line which is full of risks, dangers, and pressure from work stress and the environment. This activity aims to improve the spirituality of Indonesian Army during 4 days retreat with them of the Jesus Christ spirituality. The spirituality Jesus Christ retreat was carried out during 9-12 August 2022 at the Wismalat Podomoro, Banyuasin with a total of 45 participants. The material given includes the principle of spirituality, the spirituality of love, being a person full of love and TNI full of love and love. During the activity, the participants participated in the activity until the end, showing enthusiasm for their activities by asking questions and being open to their daily experiences.
PENGARUH PEMBERIAN REWARD DAN REINFORCEMENT TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN MATEMATIKA KELAS V
Authors: Sinaga Reflina , Sitohang Rudolf Rejekki , Lumbanraja Bogor 
Published: May 2023

Abastract: This study aims to determine the effect of giving rewards and reinforcement on student learning outcomes in mathematics in class V at SDN 064981 Medan Helvetia for the 2021/2022 academic year. In this study, researchers used quantitative methods. The population used is all SDN students. 064981 Medan Helvetia with a sample of 61 students. Sampling using non-probability sampling. The results of this study indicate that the results obtained from the correlation test can be seen in the correlation coefficient of r (count ) 0.279 r〗_(table ) 0.254, it can be concluded that the alternative hypothesis (Ha) is accepted, that is, there is a significant effect between reward and reinforcement. on the learning outcomes of SDN students. 064981 Helvetia Field. It can also be seen from the results of the t-test where t_(count )> t〗_(table ) is t_(count ) of 2.234 and t〗_(table ) of 2.000, then the hypothesis (Ha) is accepted. This shows that there is a significant positive effect between the provision of rewards and reinforcement and mathematics learning outcomes in class V SDN. 064981 Medan Helvetia for the 2021/2022 academic year. Keywords: Reward and Reinforcement, Learning Outcomes. Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh bpemberian reward dan reinforcement terhadap hasil belajar siswa pada mata pelajaran matematika kelas V di SDN 064981 Medan Helvetia tahun pembelajaran 2021/2022. Pada penelitian ini peneliti menggunakan metode kuantitatif. Populasi yang digunakan yakni seluruh siswa SDN. 064981 Medan Helvetia dengan sampel yang berjumlah 61 siswa. Pengambilan sampel dengan menggunakan nonprobability sampling. Hasil penelitian ini menunjukkan bahwa hasil yang diperoleh dari pengujian korelasi dapat dilihat pada koefisien korelasi sebesar 0,279 ≥ 0,254 maka dapat disimpulkan hipotesis alternatif (Ha) diterima yaitu terdapat pengaruh yang signifikan antara pemberian reward dan reinforcement terhadap hasil belajar siswa SDN. 064981 Medan Helvetia. Dapat juga dilihat dari hasil pengujian uji-t dimana > yaitu sebesar 2,234 dan sebesar 2,000, maka hipotesis (Ha) diterima. Hal ini menunjukkan bahwa adanya pengaruh positif yang signifikan antara pemberian reward dan reinforcement dan hasil belajar matematika di kelas V SDN. 064981 Medan Helvetia tahun pembelajaran 2021/2022. Kata Kunci: Pemberian Reward dan Reinforcement, Hasil Belajar.
ANALISIS MODEL DISCOVERY LEARNING DALAM MENGENAL HURUF ABJAD DI KELAS 1 SDN PANGGUNG LOR SEMARANG UTARA
Authors: Widyadhana Titi Cahyaningrum , Wakhyudin Husni , Saputra Henry Januar , Susilowati Deny 
Published: May 2023

Abstract: In learning in PPL 1 at SD N Panggung Lor North Semarang class 1 the problem that was encountered was that there were some students who could not read. These problems are known when students are learning Indonesian language subjects Chapter I What sounds? Theme I Sound and the five senses. There were 27 students consisting of 17 male and 10 female students consisting of several students in grade 1 SD Panggung Lor Semarang who did not know the letters of the alphabet, which made some students unable to read. In overcoming these problems in the discovery learning model research. The purpose of this study was to analyze the discovery learning model in recognizing alphabets in grade 1 SDN Panggung Lor North Semarang. The research method uses technical triangulation in collecting data using unstructured interviews conducted with teachers and students, observation and documentation. The results of this study showed an increase in understanding of the letters of the alphabet using the discovery learning model with a percentage of 0.73% to 0.93%, an increase of 0.15%.Keyword: Get to know the alphabet; discovery learning; Elementary school. Abstrak: Dalam pembelajaran pada PPL 1 di SD N Panggung Lor Semarang utara kelas 1 permasalahan yang telah ditemui adalah terdapat beberapa peserta didik yang masih belum bisa membaca. Permasalahan tersebut diketahui pada saat peserta didik melakukan pembelajaran mata pelajaran Bahasa Indonesia Bab I Bunyi apa? Tema I Bunyi dan Pancaindra. Terdapat 27 peserta didik terdiri dari 17 laki – laki dan 10 perempuan peserta didik terdiri dari Beberapa peserta didik di kelas 1 SD Panggung Lor Semarang belum mengenal huruf abjad sehingga membuat beberapa peserta didik belum mampu untuk membaca. Dalam mengatasi permasalahan tersebut di dalam penelitian model discovery learning. Tujuan dari penelitian ini adalah untuk menganalisis model discovery learning dalam mengenal huruf abjadi di kelas 1 SDN Panggung Lor Semarang Utara. Metode penelitian menggunakan triangulasi teknik dalam pengumpulan datanya menggunakan wawancara tak berstruktur yang dilakukan kepada guru dan peserta didik, observasi dan dokumentasi. Hasil dari penelitian ini terdapat peningkatan pemahaman mengenal huruf abjad menggunakan model discovery learning dengan jumlah presentase 0,73% menjadi 0,93 % mengalami jumlah peningkatan sebanyak 0,15 %.Kata Kunci: Mengenal abjad ; Discovery learning; Sekolah dasar.