bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis
Authors: Han Yuxuan , Katayama Shota , Futakuchi Mitsuru , Nakamichi Kazuya , Wakabayashi Yutaro , Sakamoto Mai , Nakayama Jun , Semba Kentaro 
Published: June 2023

Abstract

Luminal breast cancer has the highest bone metastasis frequency among all breast cancer subtypes; however, its metastatic mechanism has not been elucidated because of a lack of appropriate models. We have previously developed useful bone metastatic cell lines of luminal breast cancer using MCF7 cells. In this study, we characterized bone metastatic MCF7-BM cell lines and identified c-Jun as a novel bone metastasis marker of luminal breast cancer. The protein level of c-Jun was upregulated in MCF7-BM cells compared with that in parental cells, and its deficiency resulted in the suppression of tumor cell migration, transformation, and reduced osteolytic ability. In vivo, dominant-negative c-Jun exhibited smaller bone metastatic lesions and a lower metastatic frequency. Histologic analysis revealed that c-Jun expression was heterogeneous in bone metastatic lesions, whereas c-Jun overexpression mediated a vicious cycle between MCF7-BM cells and osteoclasts by enhancing calcium-induced migration and releasing the osteoclast activator BMP5. Pharmacological inhibition of c-Jun by the Jun amino-terminal kinase (JNK) inhibitor JNK-IN-8 effectively suppressed tumorigenesis and bone metastasis in MCF7-BM cells. Furthermore, c-Jun downstream signals were specifically correlated with the clinical prognosis of patients with the luminal subtype of breast cancer. Our results illustrate the potential benefits of a therapy that targets c-Jun to prevent bone metastasis in luminal breast cancer.

Implications:
c-Jun expression mediates bone metastasis in luminal breast cancer by forming a vicious cycle in the bone microenvironment, which reveals potential strategies for subtype-specific bone metastasis therapy.
Temporal Trends and Determinants of Stroke Risk in Patients With Medically Treated Asymptomatic Carotid Stenosis
Authors: Poorthuis Michiel H.F. , Solomon Yoel , Herings Reinier A.R. , Visseren Frank L.J. , Kappelle L. Jaap , Bots Michiel L. , Rissanen Ina , de Borst Gert J. 
Published: June 2023

BACKGROUND:
Effectiveness of carotid procedures (surgery and stenting) in patients with asymptomatic carotid artery stenosis (ACAS) depends on the absolute risk reduction that patients might receive from these procedures. We aimed to quantify the risk of ipsilateral ischemic stroke and examined temporal trends and determinants of these risks in patients with ACAS treated conservatively.

METHODS:
We conducted a systematic review from inception to March 9, 2023, of peer-reviewed trials and cohort studies describing ipsilateral ischemic stroke risk in medically treated patients with ACAS of ≥50%. Risk of bias was assessed with an adapted version of the Quality in Prognosis Studies tool. We calculated the annual incidence rates of ipsilateral ischemic stroke. We explored temporal trends and associations of sex and degree of stenosis with ipsilateral ischemic stroke using Poisson metaregression analysis and incidence rate ratios, respectively.

RESULTS:
After screening 5915 reports, 73 studies describing ipsilateral ischemic stroke rates of 28 625 patients with midyear of recruitment ranging from 1976 to 2014 were included. The incidence of ipsilateral ischemic stroke was 0.98 (95% CI, 0.93–1.04) per 100 patient-years (median duration of follow-up, 3.3 years). The incidence decreased 24% with every 5 years more recent midyear of recruitment (rate ratio, 0.76 [95% CI, 0.73–0.78]). Incidence rates of ipsilateral ischemic stroke were lower in female patients (rate ratio, 0.74 [95% CI, 0.63–0.87]) and in patients with moderate versus severe stenosis when assessed in cohort studies, with incidence rate ratios of 0.41 ([95% CI, 0.35–0.49] cutoff, 70%) and 0.42 ([95% CI, 0.30–0.59] cutoff, 80%).

CONCLUSIONS:
Reported risks of ipsilateral ischemic stroke in patients with ACAS have declined 24% every 5 years from mid-1970s onward, further challenging the routine use of carotid procedures. Risks were lower in female patients and more than twice as high with severe compared with moderate ACAS. Inclusion of these findings in individualized risk assessment can help to determine the benefit of carotid procedures in selected individual patients with ACAS.

REGISTRATION:

URL:
https://www.crd.york.ac.uk/PROSPERO/
; Unique identifier: CRD42021222940.
Role of Sports Based on Big Data Analysis in Promoting the Physique and Health of Children and Adolescents
Authors: Wen Pengfei , Wang Menghua , Wu Jinsong 
Published: June 2023

ABSTRACT
Healthy body is the foundation of young people's growth. With the popularization and globalization of the Internet, multimedia technology is rapidly changing the impact of traditional media on the growth of young people. The current health situation of young people is not optimistic. The decline in physical fitness, obesity and psychological dysplasia of adolescents have aroused the concern of all sectors of society. In recent years, the emergence and dissemination of big data (BD) has brought a new dimension to the value of data applications. The combination of BD and youth health services provides young people with good health opportunities. Through the recording, analysis and release of adolescent physical health data, the system has established an extensive knowledge database on adolescent physical and mental health, thus improving the physical health of adolescents. This paper summarized and combed the overview and application of BD, and analyzed and discussed the reasons for the continuous decline of young people's physique. Through the analysis of the application of BD in the promotion of young people's physical health, this paper proposed more achievable improvement strategies and plans, and then summarizes and discusses the experiment. According to the survey and experiment, the random simulation algorithm was introduced into daily exercise, diet and life preference. The new system and health improvement strategy designed for teenagers’ physical health using BD could help students improve their physical health by 55%.
Revealing the Trends in the Academic Landscape of the Health Care System Using Contextual Topic Modeling
Authors: Inaam ul haq Muhammad , Li Qianmu 
Published: June 2023

ABSTRACT
The health care system encompasses the participation of individuals, groups, agencies, and resources that offer services to address the requirements of the person, community, and population in terms of health. Parallel to the rising debates on the healthcare systems in relation to diseases, treatments, interventions, medication, and clinical practice guidelines, the world is currently discussing the healthcare industry, technology perspectives, and healthcare costs. To gain a comprehensive understanding of the healthcare systems research paradigm, we offered a novel contextual topic modeling approach that links up the CombinedTM model with our healthcare Bert to discover the contextual topics in the domain of healthcare. This research work discovered 60 contextual topics among them fifteen topics are the hottest which include smart medical monitoring systems, causes, and effects of stress and anxiety, and healthcare cost estimation and twelve topics are the coldest. Moreover, thirty-three topics are showing in-significant trends. We further investigated various clusters and correlations among the topics exploring inter-topic distance maps which add depth to the understanding of the research structure of this scientific domain. The current study enhances the prior topic modeling methodologies that examine the healthcare literature from a particular disciplinary perspective. It further extends the existing topic modeling approaches that do not incorporate contextual information in the topic discovery process adding contextual information by creating sentence embedding vectors through transformers-based models. We also utilized corpus tuning, the mean pooling technique, and the hugging face tool. Our method gives a higher coherence score as compared to the state-of-the-art models (LSA, LDA, and Ber Topic).
The Utilization of ChatGPT in Reshaping Future Medical Education and Learning Perspectives: A Curse or a Blessing?
Authors: Breeding Tessa , Martinez Brian , Patel Heli , Nasef Hazem , Arif Hasan , Nakayama Don , Elkbuli Adel 
Published: June 2023

Background ChatGPT has substantial potential to revolutionize medical education. We aim to assess how medical students and laypeople evaluate information produced by ChatGPT compared to an evidence-based resource on the diagnosis and management of 5 common surgical conditions. Methods A 60-question anonymous online survey was distributed to third- and fourth-year U.S. medical students and laypeople to evaluate articles produced by ChatGPT and an evidence-based source on clarity, relevance, reliability, validity, organization, and comprehensiveness. Participants received 2 blinded articles, 1 from each source, for each surgical condition. Paired-sample t-tests were used to compare ratings between the 2 sources. Results Of 56 survey participants, 50.9% (n = 28) were U.S. medical students and 49.1% (n = 27) were from the general population. Medical students reported that ChatGPT articles displayed significantly more clarity (appendicitis: 4.39 vs 3.89, P = .020; diverticulitis: 4.54 vs 3.68, P < .001; SBO 4.43 vs 3.79, P = .003; GI bleed: 4.36 vs 3.93, P = .020) and better organization (diverticulitis: 4.36 vs 3.68, P = .021; SBO: 4.39 vs 3.82, P = .033) than the evidence-based source. However, for all 5 conditions, medical students found evidence-based passages to be more comprehensive than ChatGPT articles (cholecystitis: 4.04 vs 3.36, P = .009; appendicitis: 4.07 vs 3.36, P = .015; diverticulitis: 4.07 vs 3.36, P = .015; small bowel obstruction: 4.11 vs 3.54, P = .030; upper GI bleed: 4.11 vs 3.29, P = .003). Conclusion Medical students perceived ChatGPT articles to be clearer and better organized than evidence-based sources on the pathogenesis, diagnosis, and management of 5 common surgical pathologies. However, evidence-based articles were rated as significantly more comprehensive.
Validation of the Longshi scale in assessment of function in patients from different economic, educational and regional backgrounds in China
Authors: Xiong Feng , Liu Xiangxiang , Zhou Mingchao , Wang Chunbao , Liu Quanquan , Li Jianan , Wang Yulong 
Published: June 2023

Objective This study validates performance of the Longshi scale against modified Barthel index in assessment of function in patients from different economic, educational and regional backgrounds in China. Design This is a cross-sectional study. Setting One hundred and three hospitals and rehabilitation institutions across China. Participants A total of 14,752 patients with physical and cognitive impairments were enrolled and classified to five educational levels and five family income levels; 8060 participants were further selected from five regions to study regional influences. Main measures Activities of daily living were assessed with two evaluation tools, the Longshi scale and modified Barthel index. Results of evaluation with Longshi scale performed by non-healthcare workers were validated against modified Barthel index performed by healthcare workers using Pearson's correlation test. Results There were significant positive correlations between the findings of the Longshi scale administered by non-healthcare professionals and the modified Barthel index administered by healthcare professionals. This was true for level of education (correlations ranged from 0.697 to 0.822), family income level (correlations ranged from 0.724 to 0.761) and region (correlations ranged from 0.737 to 0.776). Conclusion In a large dataset of 14,752 patients, positive correlations were found between Longshi scale and modified Barthel index measures of function. Positive correlations persisted across subgroup analysis of groups from different social, economic and regional backgrounds, and with administration by non-healthcare professionals. Clinical trial registration ChiCTR2000034067, www.chictr.org.cn
Caffeic Acid Markedly Induced Apoptosis of Human Multiple Myeloma Cells through the Caspase-dependent Pathway
Authors: Sun Likun , Ren Jing , Feng Xiumei , Li Shengli , Wang Yongjing , Jiang Yang , Zheng Chengyun 
Published: June 2023

Background Caffeic acid (CA) or 3,4-dihydroxycinnamic acid is a polyphenolic compound primarily found in coffee, herbs, berries, and other fruits. Its antioxidant, anti-inflammatory, and immunomodulatory effects on multiple health conditions have been evaluated and reported. CA’s anti-tumor effect has been reported in solid tumors, but evidence regarding liquid tumors such as multiple myeloma (MM) is limited. The increasing incidence of MM globally provides a justified rationale to explore the potential of CA on human MM cells through caspase-dependent induced apoptosis. Objectives The study explores CA’s therapeutic effect and mechanism on multiple myeloma. Materials and Methods We performed flow cytometry at different concentrations and time points after treating human MM cell lines (MM.1R, RPMI8226, and U266) with CA to identify apoptosis and changes in mitochondrial membrane potential. A Western blot was used to assess the expression of an apoptosis-related protein in MM cell lines. Statistical Analysis Used Student’s t-test was used to evaluate the mean difference between the experimental group and the control group. Results CA markedly induced the apoptosis of MM cells in a dose- and time-dependent manner. After co-incubation with CA, JC-1 (a cationic lipid fluorescent dye was used as an indicator of mitochondrial transmembrane potential), flow cytometry results showed that the mitochondrial membrane potential of MM cells significantly decreased, and the Western blot showed activation and cleavage of caspase-3, which is the classical marker of the mitochondrial apoptosis pathway. The experimental group was statistically significant compared with the control group ( p < 0.01). Conclusion Our research demonstrated that CA induced MM cell apoptosis through disturbing mitochondrial membrane integrity, followed by caspase-3 splitting, and suggested that CA might have tremendous therapeutic potential for MM treatment.
Incidence of invasive fungal infections in patients with chronic lymphocytic leukemia receiving ibrutinib within the veteran’s healthcare administration
Authors: Walker Cassandra , Horowitz Amy , Nooruddin Zohra , Frei Christopher R 
Published: June 2023

Purpose Ibrutinib is a tyrosine kinase inhibitor that is increasingly prescribed in chronic lymphocytic leukemia (CLL). Invasive fungal infections (IFIs) have been reported early after ibrutinib initiation. Timing of IFIs is within 6 months and commonly reported fungal infections include Cryptococcus, Aspergillus, and Pneumocystis. Currently, there are no recommendations for routine prophylaxis against IFIs in patients receiving ibrutinib for CLL. Objective The objective of this study was to evaluate the incidence of IFIs in patients receiving ibrutinib for CLL in first-line and relapsed/refractory (R/R) settings. Methods This was a retrospective, cohort study of patients diagnosed with CLL and initiated on ibrutinib in the Veterans Health Administration (VHA) from October 1, 2013 to March 31, 2018. Patients were included if diagnosed with a proven or probable IFI from the start date of ibrutinib to 30 days after the last dose of ibrutinib. Results Fourteen out of 1069 patients met inclusion criteria for IFI while on ibrutinib for CLL. All patients included were male with a median age of 78 years. Fifty percent of patients were initiated on ibrutinib within 3 months of last chemotherapy. IFIs occurred within 3 months (50%) and 6 months (71%) of ibrutinib initiation. Seventy-one percent of patients were continued on ibrutinib with concurrent IFI diagnosis. Conclusion The reported IFI incidence of 1.3% is comparable to current estimates of 1.2%. Future studies should examine the relationship of ibrutinib and incidence of IFIs in first-line and R/R settings in addition to identifying clinical risk factors predisposing patients to IFIs.
Experiences of Gender-Based Violence Among Disabled Women: A Qualitative Systematic Review and Meta-Synthesis Protocol
Authors: Goulden Ami , Baird Stephanie L. , Romme Kristen , Pacheco Laura , Norris Sarah E. , Norris Deborah , Faye Lisa , MacNeil Sierra , Pittman Joshua 
Published: June 2023

Background Gender-based violence (GBV) is a major public health concern and a human rights issue disproportionately affecting disabled women. Disabled women are twice as likely to experience GBV than nondisabled women, yet there has been a lack of attention to this issue. This review aims to gain a greater understanding of the experiences of GBV of disabled women through a systematic and qualitative meta-synthesis. The qualitative meta-synthesis will be conducted by a research team of academic and community members and students with varying lived and service provider experiences with disabilities and GBV. The study findings aim to promote best practices by offering solutions to increase accessible and inclusive resources and services responsive to disabled women. Methods A systematic review of qualitative studies will be performed based on searches of 12 academic databases, including MEDLINE (Ovid), APA PsycINFO (EBSCO), Sociological Abstracts (ProQuest), Social Services Abstracts (ProQuest), and SocINDEX (EBSCO). A search of the gray literature will be performed by searching the Google search engine, Google Scholar, the Community Health Online Digital Archive and Research Resource (CHODARR), and the Global Database on Violence Against Women. In addition to the database and gray literature searching, we will complete backward and forward citation tracing. Two research team members will be involved in all screening, review, data extraction, and quality assessment of studies. A third reviewer will resolve any disagreements and consult with the research team. Thematic synthesis steps will include becoming familiar with the data, developing a thematic framework, indexing the data to identify themes and codes, charting the data, and mapping and interpreting the data. The Critical Appraisal Skills Programme checklist will be used to appraise the quality of included studies. Confidence in the meta-synthesis findings will be assessed by applying the GRADECERQual approach. Review Registration This protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO): CRD42023400410.
The development and randomised feasibility trial of a Nurse-led lifestyle modification follow-up programme among post-myocardial infarction patients
Authors: Yadav Sonam , Kalal Nipin , Sharma Suresh K , Deora Surender 
Published: June 2023

Background: Cardiovascular disease is the most often occurring disease in India accounting for 24.8% of deaths. Myocardial infarction contributes to this. A higher risk of cardiovascular disease exists due to comorbidities or the unawareness of existing illness among the Indian population. There is a shortage of published research on cardiovascular disease and a lack of standard cardiac rehabilitation programmes in India. Aim: Our study aims to develop a Nurse-led lifestyle modification follow-up programme, to assess and compare the effectiveness of the programme on health outcomes and quality of life among post-myocardial infarction patients. Methods: A two arm, single-blinded, randomised feasibility trial was conducted by developing a Nurse-led lifestyle modification follow-up programme. The interventional programme was based on the information-motivation-behavioural skill model and included health education, an educational booklet, and telephone follow-up. For feasibility testing of intervention, 12 patients were randomly allocated ( n = 6/group). Patients in the control group were provided with routine care, while the intervention group was given routine care along with a Nurse-led lifestyle modification follow-up programme. Results: It was possible to use this tool. In addition to determining the tool’s feasibility for use we found that the intervention group showed a significant improvement in systolic blood pressure (BP) ( p = 0.001), diastolic BP ( p = 0.016), Body Mass Index (BMI) ( p = 0.004), and quality of life in all the subscales – physical, emotional and social ( p < 0.001) after 12 weeks of discharge. Conclusion: Findings from this study will help to reinforce designing a cost-effective care delivery system in the care of post-myocardial infarction patients. This programme is a novel approach to improve preventive, curative and rehabilitative services for the post-myocardial infarction patients in India.
Low complication rate and high implant survival at 2 years after Touch® trapeziometacarpal joint arthroplasty
Authors: Herren Daniel B. , Marks Miriam , Neumeister Sara , Schindele Stephan 
Published: June 2023

We analysed complications, revision surgeries, and patient-reported and clinical outcomes 2 years after trapeziometacarpal joint implant arthroplasty using the Touch® prosthesis. Of 130 operated patients with trapeziometacarpal joint osteoarthritis, four had to be revised owing to implant dislocation, loosening or impingement, leading to an estimated 2-year survival rate of 96% (95% confidence interval: 90 to 99). Of 101 patients available for the 2-year follow-up, complications occurred in 17, with the most frequent being de Quervain stenosing vaginosis ( n = 6) and trigger thumb ( n = 5). Pain at rest decreased significantly from a median value of 5 (interquartile range [IQR]: 4 to 7) before surgery to 0 (IQR: 0 to 1) at 2 years. Key pinch strength increased significantly from 4.5 kg (IQR: 3.0 to 6.5) to 7.0 kg (IQR: 6.0 to 8.0). We recommend surgery with the Touch® prosthesis as the standard procedure for patients with isolated trapeziometacarpal joint osteoarthritis because of the high survival rate and promising outcomes at 2 years. Level of evidence: IV
Individual goal-setting in municipal homecare: A participatory appreciative action and reflection study
Authors: Tavemark Sofia , Kihlgren Annica , Norell Pejner Margaretha , James Inger 
Published: June 2023

Background: There is a need for structural change in municipal homecare to shift power to older persons and to center the individuals in need. To make this change, the individual older persons should have enough self-determination to formulate their own individual homecare goals. Our aim was to explore how stakeholders reason about individual goal-setting in homecare. Design and methods: We theoretically and methodologically used a participatory appreciative action and reflection (PAAR) design. The stakeholders, that is, the older persons, the older persons’ relatives, and the multi-professional team, were seen as co-researchers. Data were collected between 2019 and 2020 through in depth-interviews, focus group discussions, and reference groups. The data were analyzed using thematic analysis. Results: We learned from the stakeholders that it was a struggle to sustain the individual’s goal to continue life as usual, that is, being an ordinary human being with an ordinary everyday life and maintaining individual roles. The individual wants to improve health, be active, and enjoying life. The individuals were struggling against the homecare organization, which tended to overshadow the individual’s goals. The individual’s goals fall under several legal jurisdictions and come to be overshadowed by the professionals’ dominant goal. The organization is rigid, with finances and resources creating the framework. Conclusion: We learned that older persons receiving homecare must have the same rights as other citizens in society, which is in line with public health goals.