bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social inequality in cancer survivorship: Educational differences in health‐related quality of life among 27,857 cancer survivors in Denmark
Authors: Levinsen Anne Katrine Graudal , Kjaer Trille Kristina , Thygesen Lau Caspar , Maltesen Thomas , Jakobsen Erik , Gögenur Ismail , Borre Michael , Christiansen Peer , Zachariae Robert , Christensen Peter , Laurberg Søren , de Nully Brown Peter , Hölmich Lisbet Rosenkrantz , Johansen Christoffer , Kjær Susanne K. , van de Poll‐Franse Lonneke , Saltbæk Lena , Dalton Susanne Oksbjerg 
Published: September 2023

AbstractBackgroundWith a growing population of cancer survivors in Denmark, the evaluation of health‐related quality of life (HRQoL) has become increasingly important. We describe variations in HRQoL between educational groups in a national population of cancer survivors.MethodsWe conducted a cross‐sectional questionnaire study among breast, prostate, lung, and colon cancer survivors diagnosed in 2010–2019 in Denmark. We used the EORTC QLQ‐C30 to assess HRQoL including physical, role, emotional, cognitive, social functioning, and symptoms (fatigue, nausea and vomiting, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea, and financial difficulties). Information on educational level and clinical data were extracted from national registers and clinical databases. Levels of impaired functioning and severe symptoms were identified using newly established thresholds for clinical importance. Multivariate logistic regression was used to examine associations between education and HRQoL. All statistical tests were 2‐sided.ResultsIn total, 27,857 (42%) participated in the study. Up to 72% and 75% of cancer survivors with short education (≤9 years) reported impaired functioning and severe symptoms, respectively. Cancer survivors with short compared to long education (>12 years) were more likely to report impaired functioning and severe symptoms, with for example significantly higher odds ratios (ORs) for impaired physical function (breast OR = 2.41, 99% CI = 2.01–2.89; prostate OR = 1.81, 99% CI = 1.48–2.21; lung OR = 2.97, 99% CI = 1.95–4.57; and colon cancer OR = 1.69, 99% CI = 1.28–2.24).ConclusionsCancer survivors with short education are at greater risk of impaired HRQoL than survivors with long education 2–12 years after diagnosis. This underscores the need for systematic screening and symptom management in cancer aftercare, in order to reach all cancer survivors, also cancer survivors with short education.
Left ventricular apical aneurysm resection and mitral valve replacement for apical hypertrophic cardiomyopathy
Authors: Nishiori Hironobu , Watanabe Hiroyuki , Hirano Yuichi , Otsu Masayoshi 
Published: September 2023

Key clinical messageLeft ventricular apical hypertrophic cardiomyopathy with an apical aneurysm carries a risk of thrombosis and can also lead to atrial fibrillation and functional mitral regurgitation.AbstractA 78‐year‐old woman underwent left ventricular apical aneurysm (LVAA) resection and mitral valve replacement for severe atrial functional mitral regurgitation. ApHCM can cause atrial fibrillation and atrial functional mitral valve regurgitation. LVAA resection in addition to mitral valve replacement was reasonable to prevent fatal complications associated with LVAA.
Fluorination Influences the Bioisostery of Myo‐Inositol Pyrophosphate Analogs
Authors: Hostachy Sarah , Wang Huanchen , Zong Guangning , Franke Katy , Riley Andrew M. , Schmieder Peter , Potter Barry V. L. , Shears Stephen B. , Fiedler Dorothea 
Published: September 2023

AbstractInositol pyrophosphates (PP−IPs) are densely phosphorylated messenger molecules involved in numerous biological processes. PP−IPs contain one or two pyrophosphate group(s) attached to a phosphorylated myo‐inositol ring. 5PP−IP5 is the most abundant PP−IP in human cells. To investigate the function and regulation by PP−IPs in biological contexts, metabolically stable analogs have been developed. Here, we report the synthesis of a new fluorinated phosphoramidite reagent and its application for the synthesis of a difluoromethylene bisphosphonate analog of 5PP−IP5. Subsequently, the properties of all currently reported analogs were benchmarked using a number of biophysical and biochemical methods, including co‐crystallization, ITC, kinase activity assays and chromatography. Together, the results showcase how small structural alterations of the analogs can have notable effects on their properties in a biochemical setting and will guide in the choice of the most suitable analog(s) for future investigations.
Impact of M‐Site Cation Variation on Structural, Electronic, and Optical Properties of Pd3M2Se2 (M = Pb, Sn) Dichalcogenides: A Computational Study
Authors: Rabu Rabeya Akter , Hossain Kamal , Khanom Mst. Shamima , Hossain Md. Kamal , Ahmed Farid 
Published: September 2023

AbstractThe optimized structure of Pd3M2Se2 (M = Pb and Sn) compounds is used to explore the M‐Site cation variation. Density functional theory (DFT) using generalized gradient approximation (GGA) with Hubbard potential (GGA+U) and Wu and Cohen (GGA+WC) functionals are used to examine the physical characteristics. The chemical stability is indicated by negative values for the formation energy and obtained as −26.75 eV and −28.25 eV for Pd3Pb2Se2 and Pd3Sn2Se2 compounds respectively. The feeble interaction of Se‐4p and Pb‐6p orbital electrons in the conduction band results in a considerable contribution. As a result, the energy bands of the Pd3Pb2Se2 structure are altered in such a way that it has a high electrical conductivity. The Pd3Pb2Se2 and Pd3Sn2Se2 structures are metallic, with both ionic and covalent interactions, according to electronic population studies. While the extinction coefficient for the Pd3Pb2Se2 compound is 4.20 at 0.65 eV, the Pd3Sn2Se2 structure has a highest peak of 7.20 at this energy, indicating their photoelectric applicability. The Pd3Pb2Se2 and Pd3Sn2Se2 structures seemed to be transparent to photons energy at 16.4 eV and 18.20 eV respectively. These shandite compounds showed superior absorption for Ultraviolet (UV) photon energy as well as efficient infrared and visible light absorption with conductivity.
Polymeric Electrolytes for Solid‐state Lithium Ion Batteries: Structure Design, Electrochemical Properties and Cell Performances
Authors: Su Gang , Zhang Xin , Xiao Min , Wang Shuanjin , Huang Sheng , Han Dongmei , Meng Yuezhong 
Published: September 2023

AbstractSolid‐state electrolytes are key to achieving high energy density, safety, and stability for lithium‐ion batteries. In this Review, core indicators of solid polymer electrolytes are discussed in detail including ionic conductivity, interface compatibility, mechanical integrity, and cycling stability. Besides, we also summarize how above properties can be improved by design strategies of functional monomers, groups, and assembly of batteries. Structures and properties of polymers are investigated here to provide a basis for all‐solid‐state electrolyte design strategies of multi‐component polymers. In addition, adjustment strategies of quasi‐solid‐state polymer electrolytes such as adding functional additives and carrying out structural design are also investigated, aiming at solving problems caused by simply adding liquids or small molecular plasticizer. We hope that fresh and established researchers can achieve a general perspective of solid polymer electrolytes via this Review and spur more extensive interests for exploration of high‐performance lithium‐ion batteries.
Exploring the prospective relationships between food addiction symptoms, weight bias internalization, and psychological distress in Chinese adolescents
Authors: Barnhart Wesley R. , Cui Tianxiang , Cui Shuqi , Ren Yaoxiang , Ji Feng , He Jinbo 
Published: September 2023

AbstractObjectiveRelationships exist between food addiction symptoms, weight bias internalization, and psychological distress, yet previous research is primarily cross‐sectional with adults from Western contexts. We examined the prospective relationships between food addiction symptoms, weight bias internalization, and psychological distress in Chinese adolescents.MethodsOver three time points (Time 1, baseline; Time 2, 6‐months; Time 3, 12‐months) spanning 1 year, we examined cross‐sectional and bi‐directional relationships between food addiction symptoms, weight bias internalization, and psychological distress in Chinese adolescents (N = 589; aged 14–18 years at baseline). Pearson correlations and cross‐lagged models examined the cross‐sectional and longitudinal relationships between food addiction symptoms, weight bias internalization, and psychological distress.ResultsCross‐sectional correlations suggested positive relationships between food addiction symptoms, weight bias internalization, and psychological distress at each time point. Regarding bi‐directional relationships, higher psychological distress was associated with both higher weight bias internalization and higher food addiction symptoms at the following time points. However, food addiction symptoms and weight bias internalization were not prospectively associated. Time 2 psychological distress did not significantly mediate the relationship between Time 1 weight bias internalization and Time 3 food addiction symptoms.DiscussionFindings suggest no direct longitudinal link between food addiction symptoms and weight bias internalization and vice versa. However, findings do suggest that psychological distress is temporally associated with higher food addiction symptoms and weight bias internalization in Chinese adolescents. Targeting psychological distress may prove useful in treatments of food addiction symptoms and weight bias internalization in Chinese adolescents.Public SignificancePositive associations exist between food addiction symptoms, weight bias internalization, and psychological distress, but findings are largely cross‐sectional and bound to adult populations from Western contexts. Using a longitudinal design in Chinese adolescents, findings suggested that baseline psychological distress was associated with higher food addiction symptoms and higher weight bias internalization at follow‐up time points. Treatments targeting psychological distress may be helpful in reducing food addiction symptoms and weight bias internalization in Chinese adolescents.
Tensions between collective‐self forgiveness and political repair
Authors: Wenzel Michael , Quinney Blake , Wohl Michael J. A. , Barron Anna , Woodyatt Lydia 
Published: September 2023

AbstractFaced with collective guilt, perpetrator groups may seek collective‐self forgiveness. However, does this diminish their support for political repair? Advancing the concept of collective‐self forgiveness, we distinguish between end‐state collective‐self forgiveness as restored moral identity and two processes: pseudo collective‐self forgiveness as defensive downplaying and genuine collective‐self forgiveness as ‘working through’ the ingroup's guilt. In three studies, non‐Indigenous Australians (N = 369, 800 and 785) were surveyed about currently debated constitutional changes for the recognition and empowerment of Indigenous Australians. Pseudo and genuine collective‐self forgiveness were positively related to end‐state collective‐self forgiveness. Pseudo and end‐state were negative, but genuine collective‐self forgiveness positively, related to support for repair and truth telling. Participants identifying with both Australians and Indigenous Australians more strongly endorsed genuine collective‐self forgiveness. The results suggest a pathway for perpetrator group members to balance identity needs with commitment to repair, but highlight drawbacks of seeing collective‐self forgiveness as an end‐state objective.
High‐pressure methane storage on metal‐organic frameworks
Authors: Chuvikov Sergey V. , Klyamkin Semen N. 
Published: September 2023

AbstractMethane storage performance of a series of metal‐organic frameworks (MOFs) has been thoroughly examined over a wide pressure range up to 750 bar. Based on volumetric adsorption measurements, crystal structure and porous texture characterization, excess, total and working adsorption capacities, and heat of adsorption as functions of pressure have been evaluated. It has been found that the use of MOFs demonstrates a significant advantage in methane storage capacity over compressed gas, and the Gain can reach 300% to 400% depending on the pressure‐temperature operating conditions. However, the benefit of adsorption storage drops with increasing pressure. Even for the best MOF adsorbent, this methane storage method becomes technologically unreasonable above 280 bar. The data obtained allowed us to conclude that conventionally reported excess adsorption does not give a complete picture of the effectiveness of MOFs. Besides high specific surface area, optimal density of the skeleton and moderate heat of adsorption are required for the best storage performance.
Protective effects of fruit extract of Rosa canina and quercetin on human umbilical vein endothelial cell injury induced by hydrogen peroxide
Authors: Forouzanfar Fatemeh , Tabatabaei Zeynab , Emami Seyed Ahmad , Ayati Zahra , Tayarani‐Najaran Zahra 
Published: September 2023

AbstractThe Nastaran plant, with the scientific name of Rosa canina, has been used since ancient times as a plant with medicinal properties. In the present study, human umbilical vein endothelial cells (HUVECs) were used to examine the protective effects of R. canina fruit extract (RCFE) and its flavonoid ingredient (quercetin) against H2O2‐induced cell injury. RCFE (1.25–20 μg/mL) and quercetin (1.25–20 μM) were exposed to H2O2‐oxidizing agent (1 and 2 mM) and the protective effect was examined on HUVEC cells by Alamar Blue test. The amount of intracellular reactive oxygen species (ROS) was measured by using DCFDA reagent by fluorimetric method. The effects of RCFE and quercetin on cell apoptosis were studied by staining with hypotonic PI solution and flow cytometry. The amount of PARP and survivin involved in the apoptotic process was measured using the western blot analysis. The results of the Alamar Blue test showed that RCFE and quercetin could reduce the toxicity of H2O2. RCFE and quercetin were able to significantly increase cell viability against H2O2. Also, it was found that RCFE and quercetin reduced the production of ROS by H2O2. It was found that RCFE and quercetin reduced the apoptosis and sub‐G1 peak area in flow histogram after exposure of cells to H2O2. Based on western blot results, pretreatment with RCFE and quercetin could significantly increase survivin protein after exposure of cells to H2O2. Also, RCFE and quercetin could significantly reduce the amount of cleaved PARP after exposure of cells to H2O2. RCFE and its ingredient (quercetin) can be considered a promising source of phytochemicals in the prevention of cardiovascular diseases.
Enantio‐ and Diastereoselective (Ipc)2BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides
Authors: Pedzisa Lee , Monastyrskyi Andrii , Parker Camille D. , Roush William R. 
Published: September 2023

AbstractHighly enantio‐ and diastereoselective (Ipc)2BOTf mediated aldol reactions of morpholine carboxamides are described. A wide variety of α‐substituted N‐acyl morpholine carboxamides were successfully employed, including α‐bromo, α‐chloro, α‐vinyl and para‐methoxyphenyl morpholine carboxamides which provided the corresponding aldol products in moderate to excellent yields, and generally with high enantio‐ and diastereoselectivities.
Patients' preferences for chronic lymphocytic leukemia treatment: The CHOICE study
Authors: Sportoletti Paolo , Laurenti Luca , Chiarenza Annalisa , Gaidano Gianluca , Albi Elisa , Mauro Francesca Romana , Trentin Livio , Vallisa Daniele , Pane Fabrizio , Cuneo Antonio , Albano Francesco , Zamprogna Giulia , Coscia Marta , Gozzetti Alessandro , Reda Gianluigi , Caira Morena , Finsinger Paola , Gualberti Giuliana , Iannella Emilia , Malgieri Simona , Molica Stefano 
Published: September 2023

AbstractChronic lymphocytic leukemia (CLL) therapies differ in efficacy, side effects, route, frequency, and duration of administration. We assessed patient preferences for treatment attributes and evaluated associations with disease stage, treatment line, and socio‐demographic characteristics in a cross sectional, observational study conducted at 16 Italian hematology centers. Study visits occurred between February and July 2020; 401 adult patients with CLL (201 Watch and Wait (W&W), 200 treated) participated in a discrete choice experiment (DCE), composed of 8 choices between pairs of treatment profiles with different levels of 5 attributes of currently available CLL treatments (length of response, route and duration of administration, risk of side effects including diarrhea, infections, or organ damage). Health‐related quality of life was assessed with the EQ‐5D‐5L, EORTC QLQ‐C30 and QLQ CLL‐16. Previously treated patients had longer disease duration (7 vs. 5 years), higher prevalence of serious comorbidities (45.5% vs. 36.2%) and high‐risk molecular markers (unmutated IGHV 55.6% vs. 17.1%; TP53 mutation 15.2% vs. 4.0%). Health‐related quality of life scores were similar between groups. In the DCE, W&W patients rated “possible occurrence of infections” highest (relative importance [RI] = 36.2%), followed by “treatment and relevant duration” (RI = 28.0%) and “progression‐free survival (PFS)” (RI = 16.9%). Previously treated patients rated “treatment and relevant duration” highest (RI = 33.3%), followed by “possible occurrence of infections” (RI = 28.8%), “possible occurrence of organ damage” (RI = 19.4%), and “PFS” (RI = 9.8%). Concern over infection was rated highest overall; unexpectedly PFS was not among the most important criteria in either group, suggesting that the first COVID‐19 pandemic wave may have influenced patient preferences and concerns about CLL therapy options.
Analytical study of dual‐porosity coastal aquifer with generalized nonlinear water transfer term
Authors: Ma Kuo‐Chen , Chuang Mo‐Hsiung , Chang Ya‐Chi , Lin Ying‐Fan 
Published: September 2023

AbstractThis study proposes a new mathematical model for the hydraulic head distribution induced by the tidal wave in fractured coastal aquifers. The flow in the fractured aquifer is described by adopting the well‐known dual‐porosity (DP) concept. It simply describes the interaction of the flow between the fractures and matrix blocks. The past studies commonly used the lumped‐distributed approach, a first‐order mass transfer approximation, to reflect such a flow interaction. Herein, we incorporate a new generalized transfer term (GTT) into the DP model. The weighting factor in the GTT is capable of reflecting the geometrical properties of the matrix flow. The GTT can reduce to the first‐ and second‐order terms by setting the weight to zero and one, respectively. Moreover, the sensitivity analysis is used to delve into the impacts of the aquifer parameters on the flow response in the coast aquifer, and the effects of the model parameters on the head amplitude and phase shift are explored in this study. The sensitivity analysis is performed to assess the hydraulic properties of the coast aquifer in response to the hydraulic head. Overall, we believe that the present model facilitates in developing sound plans of water resources management in coastal regions.
TRAIL‐conjugated liposomes that bind natural killer cells to induce colorectal cancer cell apoptosis
Authors: Greenlee Joshua D. , Zhang Zhenjiang , Subramanian Tejas , Liu Kevin , King Michael R. 
Published: September 2023

AbstractNatural killer (NK) cell functionality is a strong indicator of favorable prognosis in cancer patients, making NK cells an appealing therapeutic target to prevent lymph node dissemination. We engineered liposomes that are conjugated with anti‐CD335 antibodies for NK cell targeting, and the apoptotic ligand TRAIL to kill cancer cells. Liposomes were made using a thin film hydration method followed by extrusion to approximately 100 nm in diameter and conjugation of proteins via thiol‐maleimide click chemistry. TRAIL/anti‐CD335 liposomes successfully bound to isolated NK cells. Once piggybacked to the surface of NK cells, these “Super Natural Killer Cells” were able to more effectively kill oxaliplatin‐resistant SW620 cells and metastatic COLO205 colorectal cancer cells via TRAIL‐mediated apoptosis compared to NK cells alone. Importantly, Super NK cells were more effective under physiological levels of fluid shear stress found in the lymphatics. Liposome biodistribution after intravenous administration confirmed the sustained presence of liposomes within the spleen and tumor draining mesenteric lymph nodes for at least 4 days. These results demonstrate the enhanced apoptotic effects of NK cells armored with liposomal TRAIL against clinically relevant colorectal cancer cells, providing the groundwork for in vivo treatment studies in mouse models of colorectal cancer metastasis.
The non‐causative role of abnormal serum uric acid in intervertebral disc degeneration: A Mendelian randomization study
Authors: Cai Yang‐Ting , Li Yong‐Xian , Wang Li‐Ren , Mo Ling , Li Ying , Zhang Shun‐Cong 
Published: September 2023

AbstractBackgroundIntervertebral disc degeneration (IDD) is a common musculoskeletal disorder that contributes significantly to disability and healthcare costs. Serum urate concentration has been implicated in the development of various musculoskeletal conditions. While previous observational studies have suggested an association between the two conditions, it might confound the effect of serum urate concentrations on IDD. This Mendelian randomization (MR) study aimed to investigate the causal relationship between serum urate concentration and IDD.MethodsWe performed a two‐sample MR analysis using summary‐level data from genome‐wide association studies (GWAS) of serum urate concentration (n = 13 585 994 European ancestry) and IDD (n = 16 380 337 European ancestry). Single nucleotide polymorphisms (SNPs) significantly associated with serum urate concentration (p < 5 × 10−8) were selected as instrumental variables. The associations between genetically predicted serum urate concentration and IDD were estimated using the inverse‐variance weighted (IVW) method, with sensitivity analyses employing the weighted median, MR‐Egger, and MR‐PRESSO approaches to assess the robustness of the findings.ResultsIn the primary IVW analysis, genetically predicted serum urate concentration was unrelated associated with IDD (odds ratio [OR] = 1.00, 95% confidence interval (CI): 1.00–1.00, p = 0.17)). The results remained consistent across the sensitivity analyses, and no significant directional pleiotropy was detected (MR‐Egger intercept: p = 0.15).ConclusionsThis MR study provides evidence that there is no causal relationship between serum urate concentration and IDD. It suggests previous observational associations may be confounded. Serum urate levels are unlikely to be an important contributor to IDD.