bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Low‐Scale Seesaw Solution to the MW$M_W$ and (g−2)μ$(g-2)_\umu$ Anomalies
Authors: de Giorgi Arturo , Merlo Luca , Pokorski Stefan 
Published: March 2023

AbstractThe recent CDF‐II measurement of the W‐boson mass shows a strong tension with the corresponding Standard Model prediction. Once active neutrino masses are explained in the context of the Low‐Scale Seesaw mechanisms, this tension can be resolved. We investigate the possibility of explaining the longstanding muon anomalous magnetic moment anomaly within the same frameworks. We present a simplified extension of the Standard Model, accounting only for the second lepton generation, that describes a massive active neutrino and provides a combined solution to these anomalies. The model is renormalisable and introduces in the spectrum, beyond the sterile species of the Low‐Scale Seesaw mechanism, only one pair of exotic vector‐like leptons, doublets under the electroweak symmetry. We moreover discuss the extension of this model to the realistic three‐family case.
Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats
Authors: Liu Dandan , Liu Yunjiao , Qian Xian , Yang Junwei , Li Chengjian , Zhu Lingfeng , Zhou Jin 
Published: March 2023

AbstractBoth ligustrazine and tangeretin are usually prescribed in the treatment of cardiovascular diseases, which makes their co‐administration possible. The investigation of the interaction between ligustrazine and tangeretin is necessary for the clinical compatibility of their source herbs. This study aimed to investigate the interaction of ligustrazine and tangeretin during their co‐administration. The pharmacokinetics of ligustrazine (15 mg/kg) was investigated in the presence of 50, 100, and 150 mg/kg tangeretin in rats with six of each. A single dose of ligustrazine was set as the control. The effect of tangeretin on the in vitro metabolic stability of ligustrazine was also investigated in rat liver microsomes. Tangeretin significantly reduced the system exposure of ligustrazine under all experimental concentrations. Specifically, tangeretin reduced the AUC (from 48.86 ± 12.57 to 41.02 ± 4.85 (50 mg/kg tangeretin), 31.47 ± 5.26 (100 mg/kg tangeretin), and 27.55 ± 9.60 (150 mg/kg) μg/mL × h), MRT (from 7.05 ± 0.26 to 6.33 ± 0.48, 5.53 ± 0.68, and 5.21 ± 1.31 h), Cmax (from 7.45 ± 0.44 to 6.03 ± 0.44, 5.24 ± 0.47, and 5.02 ± 0.56 μg/mL), and t1/2 (from 5.90 ± 1.27 to 4.84 ± 1.19, 3.48 ± 1.33, 3.09 ± 0.62 h) in rats. In vitro, tangeretin also reduced the metabolic stability of ligustrazine behaved as the decreased half‐life and increased intrinsic clearance rate. Co‐consumption of ligustrazine with tangeretin induced interactions, which shortens the system exposure of ligustrazine. This study provides theoretical guidance for the clinical prescription of ligustrazine‐ and tangeretin‐containing herbs.
The SARS‐CoV‐2 Omicron Variant and its Multiple Sub‐lineages: Transmissibility, Vaccine Development, Antiviral Drugs, Monoclonal Antibodies, and Strategies for Infection Control – a Review
Authors: Mohapatra Ranjan K. , Verma Sarika , Kandi Venkataramana , Sarangi Ashish K. , Seidel Veronique , Das Subrata Narayan , Behera Ajit , Tuli Hardeep Singh , Sharma Ashwani K. , Dhama Kuldeep 
Published: March 2023

AbstractThe Omicron (B.1.1.529), fifth variant of concern (VOC) of SARS‐CoV‐2, initially identified following a steep increase in COVID‐19 cases in Southern Africa in November 2021. It is a highly‐mutated variant and is more contagious as compared with the Delta variant, however less deadly. Due to its high transmission rate, it spreads dramatically, and causing huge surges worldwide. It causes “mild infection”, with hospitalisations less likely to occur. However, this variant is known to show resistance to neutralizing antibodies (nAbs) generated through vaccination and/or prior infection as well as to monoclonal antibodies (mAbs) used to treat COVID‐19 patients. In many countries, booster doses of vaccines have been recommended to increase the protective levels of antibodies in vaccinated individuals. Along with the implementation of appropriate prevention and control strategy measures, current efforts are also focussed on the development of better vaccines and mAbs to counter this variant. This review highlights the global health concerns and challenges posed by the Omicron variant and present an update on its sub‐lineages.
Recent Advances on the Corrosion Inhibition Behavior of Schiff base Compounds on Mild Steel in Acidic Media
Authors: Afshari Fahimeh , Ghomi Erfan Rezvani , Dinari Mohammad , Ramakrishna Seeram 
Published: March 2023

AbstractCorrosion inhibitors for mild steels subjected to aggressive media are needed by various industries, especially in power plants, petrochemical, automobile, and pharmaceutical. Accordingly, Schiff bases as a category of organic inhibitors have demonstrated efficient protecting activity in corrosive environments. This review focuses on the corrosion inhibitory performance of different Schiff bases for mild steel in acidic media and underlines the reports on which the protecting efficiency and applicability of Schiff bases have been affected by introducing different reagents as well as considering the environmental and structural issues. Therefore, discussed influential factors could endow approaches to design and apply more effective Schiff bases in the corrosion field, particularly alternatives under ecological guidelines and high inhibition efficiency.
An Experimental and Quantum (QTAIM) Performance Study of a Proposed Molecular Chemosensor: A Quinazolinone‐Based Sensor for Hg2+ Ion Detection
Authors: Hadi Hamid , Safari Reza , Landarani‐Isfahani Amir , Shamlouei Hamid Reza 
Published: March 2023

AbstractThis work synthesized a novel colorimetric ligand based on the compound quinazolinone (Sensor) and investigated it. The sensing activity of the sensor toward different cation was studied. The sensor demonstrated a highly selective colorimetric sensing toward Hg2+ with a detection limit of 0.1 ppb and visual color change from colorless to Purple in methanol‐water solvents (v/v, 10,90). The cation binding character was determined using visual inspection, UV–Vis, and fluorescence analyses. In the computational part, the interaction between the receptor and Hg2+ ion was investigated using density functional theory (TD‐DFT) and quantum theory of atoms in molecules (QTAIM) in the solution phase (in the presence of water as solvent and the CPCM model). Theoretical studies have shown that electronic properties such as energy gap, absorption energy, charge/energy transfer, and optical properties change dramatically in the presence of Hg2+ cations. Also, the effect of the electric field on the electronic properties of the sensor/Hg2+ complex improved the Hg2+ cation adsorption process.
Rapid Adsorption Methylene Blue from Aqueous Solution using Manganese Dioxide Nanowires: Facile Synthesis, Characterization, Kinetics, Thermodynamics and Mechanism Analysis
Authors: Xu Naicai , Bian ShaoJu , Ding Xiuping , Shi Dandan , Dong Chengjun 
Published: March 2023

AbstractManganese dioxide nanomaterials with high crystallinity and purity was prepared quickly by a simple hydrothermal reaction, and the effect of hexadecyl trimethyl ammonium chloride (CTAC) on crystal form, morphology and pore structure of manganese dioxide was investigated. Removal of methylene blue from aqueous solution by adsorption onto two manganese dioxide adsorbents was studied. The material characterization results showed that manganese dioxides have (2×2) tunnel structure and nanowires morphology. BET surface area and pore volume of ɑ‐MnO2 (CTAC) was 58.99 m2/g and 0.2081 cm3/g, respectively. The adsorption results showed that pH value had a certain effect on the removal of methylene blue. The adsorption kinetics results indicated that the adsorption rate of ɑ‐MnO2 and ɑ‐MnO2 (CTAC) to methylene blue was very fast, most adsorption was completed within 5 minutes, and the adsorption equilibrium was reached after 2 hours. The removal efficiency of ɑ‐MnO2 and ɑ‐MnO2 (CTAC) was 71.27 % and 78.92 %, respectively. Pseudo‐second‐order kinetic model was better fitted with adsorption data than pseudo‐first‐order model, suggesting adsorption behavior is controlled by chemical processes. Additionally, the free energy change (ΔGΘ) was determined by Van′t Hoff equation is negative, which confirms the adsorption process is spontaneous and feasible. The adsorption mechanism involves a complex process of electrostatic attraction, charge‐independent adsorption, physical adsorption, hydrogen bonding and redox.
Amino groups modified MnOx‐PUF applied in indoor air purification: removing formaldehyde at room temperature
Authors: Zhu Guang Shuo , Zheng Jia Yu , Bao Han Chang , Zhang Hao , Chang Peiyu , Kang Zhao Wen , He Junda , Xia Yi , Song Xuemei , Yan Hui 
Published: March 2023

AbstractIndoor formaldehyde (HCHO) pollution has more and more serious adverse effects on human health, it is urgent to develop a material that can be embedded in the air purifier to achieve HCHO's degradation efficiently. In this work, based on the carrier material of polyurethane foam (PUF) modified by amino groups diethanolamine (DEA), we propose a strategy to prepare a manganese oxide compound catalyst (DEA‐MnOx‐PUF). During the static testing (CHCHO: 11.591 ppm, T: 25 °C), the catalyst shows higher HCHO removal efficiency (93.9 %) than that of unmodified MnOx‐PUF catalyst (88.6 %), and it achieves high HCHO‐to‐CO2 conversion (68.5 %). Additionally, during the continuous single‐pass catalysis testing (CHCHO: 11.591 ppm, T: 25 °C, 240000 mL/(gcath)), HCHO removal efficiency can be maintained around at 95 % within 50 hours. The excellent performance is attributed to the continuous decomposition of intermediates during the catalytic process by amino groups cross‐linked on the surface of the catalyst. Based on the block whole MnOx‐based catalyst DEA‐MnOx‐PUF, this work will provide a new route to develop a powerful purifier material with long‐term efficient removal of HCHO.
8‐Hydroxyquinoline, Derivatives and Metal‐Complexes: A Review of Antileukemia Activities
Authors: Bissani Gasparin Carolina , Pilger Diogo André 
Published: March 2023

Abstract8‐Hydroxyquinoline and its derivatives consist of a group of metal‐binding ligands capable of reaching complexes that present several biological activities. In the present study, we collate and discuss data regarding the antileukemia activities of 8‐hydroxyquinoline (8HQ) compounds to provide an overview of their mechanisms of actions, and a compilation of cytotoxicity data against diverse leukemia cell lines. The pharmacological activities of this class of agents are associated primarily with their ability to coordinate metals and interact with multiple biological targets. We found consistent evidence that 8HQ exerts promising proapoptotic features through its direct interaction with deoxyribonucleic acid (DNA) and inhibition of multiple targets, such as the proteasome, nuclear factor kappa B (NF‐κB), histone deacetylase (HDAC), bromodomain and extra terminal (BET) proteins and janus kinases (JAKs), in addition to inducing autophagy associated cell death. Thus, we provide substantial evidence for the repositioning potential of the 8HQ class for the treatment of leukemia, a hematological malignancy for which urgent advances in therapeutic approaches are needed to overcome conventional therapy limitations.
Chemically Oxidized Carbon Paper as a Free‐Standing Electrode for Supercapacitor: An Insight into Surface and Diffusion Contribution
Authors: Waseem Sadiya , Dubey Prashant , Singh Mandeep , Sundriyal Shashank , Maheshwari Priyanka H. 
Published: March 2023

AbstractCarbon paper has been synthesized by paper making process followed by composite formation, and further chemically oxidized by immersing into a mixture of sulphuric acid and potassium dichromate to be used as an electrode for supercapacitor applications. XRD and Raman spectra were used to analyze the structure, and the defects in the samples respectively, in due course of oxidation. FESEM images revealed the morphology of oxidized samples to be rougher, which contributes towards increased active sites for reaction. The sample (COCP‐60) optimized via electrochemical studies, was further tested in various electrolytes to study the electrode/electrolyte interaction. It delivered a highest areal capacitance of 6.02 F/cm2 (231.5 F/g) in acidic electrolyte at a current density of 5 mA/cm2 (0.19 A/g). This findings were further corroborated by surface and diffusion contribution studies wherein it was found that diffusion is more profound with acidic electrolyte. The supercapacitor device fabricated with COCP‐60 electrode delivered an energy density of 0.41 Wh/cm2 at 2.83 W/cm2 power density with coulombic efficiency of 98 %, and cyclic stability of ∼90 % for over 5000 cycles.
Electrochemical Detection of 4‐Nitrophenol Using A Screen‐Printed Carbon Electrode Modified by Rod‐Shaped Nickel Oxide Nanoparticles
Authors: Somasundaram Gunasekaran , Balasubramanian Selva , Vaiyapuri Thirumurugan , Muthiah Senthilkumar , Sivanesan Jothi Ramalingam , Nesakumar Noel , Shanmugam Shankar , Gunasekaran Balu Mahendran 
Published: March 2023

Abstract4‐Nitrophenol (4‐NP) is a hazardous organic pollutant with detrimental effects on plants, animals, and humans. Detection of 4‐NP in the environment is therefore a necessary requirement. We demonstrate a facile green synthesis of nickel‐oxide (NiO) nanoparticles employing Brassica oleracea vegetable extract (cauliflower) as a green stabilizing and reducing agent. Green synthesized NiO nanoparticles were used as an efficient electrode material for the highly sensitive electrochemical detection of 4‐NP. The abundant polyphenolic component in the vegetable extract of Brassica oleracea is capable of reducing and stabilizing C2NiO4 into NiO nanoparticles. The as‐synthesized NiO nanoparticles were characterized by UV‐Vis spectroscopy, FTIR spectroscopy, Raman spectroscopy, photoluminescence spectroscopy, and X‐ray photoelectron spectroscopy (XPS), and the structural phase of NiO nanoparticles was confirmed using powder X‐ray diffraction technique. The surface morphology of the NiO nanoparticles was analyzed using scanning electron microscopy (SEM). Linear sweep voltammetry (LSV) and Differential pulse voltammetry (DPV) techniques were adopted to for the electrochemical determination of 4‐NP after drop casting the NiO nanoparticles onto the screen‐printed carbon electrode (SPCE). The developed sensor (NiO/SPCE) showed a high sensitivity of 1.055 μA/nM over a wide linear‐range from 1 to 10 nM with a detection limit of 0.519 nM for the detection of 4‐NP using DPV technique.
New Heterofused Thiazolo/Pyrazinedione Hybrids as Promising Building Blocks for Anticancer Drug Development: Synthesis, Biological and Drug‐Likeness Evaluation
Authors: Javier Cala L. , Álvarez Santos Marilyn R. , Méndez‐Sánchez Stelia C. , Yepes Andres F. , Romero Bohórquez Arnold R. 
Published: March 2023

AbstractA new series of heterofused thiazolo/pyrazinedione hybrids were designed, synthetized and their cytotoxicity potential was evaluated against different cancer cell lines. Besides, drug‐likeness and in silico ADME/Tox studies were carried out using free server tools. The heterofused hybrids 3‐aryl‐thiazolo[3,4‐a]pyrazine‐5,8‐diones 3 a–o were obtained in moderate to good yields (30–80 %) and with high diastereomeric ratio. Notably, hybrids 3 g–j showed good cytotoxic effect on Hep‐G2 cancer cells IC50 (28.6±4.9 μM, 54.2±15.4 μM, 95.2±1.9 μM, 68.6±1.6 μM) respectively, while compounds 3 l–m were cytotoxic on B16F10 melanoma cancer cells IC50 (20.9±5.3 μM, 30.0±6.4 μM). Furthermore, the new compounds were relatively non‐toxic on Vero cells. In silico drug‐likeness and ADME/Tox studies suggest optimal pharmacokinetic profile for all hybrids. Altogether, these new heterofused hybrids could be considered as promising scaffolds in cancer chemotherapy.
Hematite Particle Size Effect on Combustion Performance of Fire Extinguishing Composites
Authors: Rohilla Meenakshi , Saxena Amit , Prakash Braham , Tanwar Rajesh Kumar , Narang Rajiv , Tyagi Yogesh Kumar 
Published: March 2023

AbstractHematite nanoparticles (α‐Fe2O3) were successfully synthesised using facile and eco‐friendly hydrothermal method. Synthesised hematite nanoparticles were characterized using X‐ray diffraction, Fourier transform infrared spectroscopy, surface area analysis and transmission electron microscopy. Nano/micro particles of Hematite (1, 3&5 %, w/w) were incorporated in aerosol forming composite (AFC). For the first time, catalytic effect of nano and micro size hematite on performance of AFC has been creatively investigated with respect to combustion and fire extinguishment parameters. Incorporation of nano hematite (5 %, w/w) in AFC reduced the combustion temperature (by 11 %) and tremendously boosted the burn rate & combustion efficiency by 30&7.5 % respectively. This in turn produced the aerosols in less time and put out the fire quickly (<5 s). Hematite nano counterpart was discovered to be more promising than its micro equivalent. This exploratory study is valuable in the field of development of futuristic ultra‐fast fire extinguishants.
Scalable Synthesis of Bimetallic CoFe Alloy Nanoparticles for Efficient Oxygen Evolution Reaction
Authors: Yang Chunyan , Ma Xuke , Zhou Jiaqi , Zhao Yafei , Xiang Xu , Shang Huishan , Zhang Bing 
Published: March 2023

AbstractThe development of efficient electrocatalysts towards oxygen evolution reaction (OER) is critical for large‐scale applications of electrochemical water splitting and metal‐air cells. Usually, transition metal alloys exhibit superior activity for OER. Herein, we successfully prepared a series of scalable transition metal alloys with homogeneous size by a facial sol‐gel self‐propagating combustion method. Among them, the CoFe alloy displayed the highest oxygen evolution reaction (OER) activity, achieving an overpotential of 310 mV at 10 mA cm−2. After running OER tests for 48 h, the activity of CoFe alloy hardly decayed, indicating its outstanding stability. This work may make some contributions to the production of promising transition metal alloy catalysts and related energy equipment applications.
Electrochemical Characteristics of Polyaniline Nanofibers and Active Chromium Sulfide Nanoparticles for Asymmetric Supercapacitor Applications
Authors: Iqbal Hifza , Nazim Amina , Haq Mahmood Ul , Hassan Ather , Mahmood Sajid , Muhammad Zahir , Iqbal Muhammad Faisal 
Published: March 2023

AbstractMetal sulfides exhibit rich surface chemistry and electrochemical features and their comparison with polyaniline may give a new perspective to supercapacitor applications. Active chromium sulfide nanoparticles and polyaniline nanofibers were synthesized using the solvothermal and polymerization process, respectively. Chromium sulfide nanoparticles reveal a good specific capacitance of 594.38 F/g at the current density of 1 mA/cm2, meanwhile, the polyaniline nanofibers exhibit a maximum specific capacitance of 150 F/g at the current density of 4 mA/cm2, through the galvanostatic charge‐discharge profile. The power density of the polyaniline was found 3111 W/Kg, which is greater due to the conductive nature of polyaniline, meanwhile, chromium sulfide nanoparticles also exhibit a reasonable power density of 2403.06 W/Kg. Comparatively, chromium sulfide nanoparticles maintained specific capacitance and power density. The two electrodes asymmetric system exhibits a good coulomb efficiency of 100 % at 1 mA/cm2. So, chromium sulfide nanoparticles exhibit good electrochemical characteristics for supercapacitor applications.
Tag‐Free Antibody Modification Mediated by Lipoic Acid Ligase A: Application to Antibody‐Drug Conjugates Production
Authors: Yamazaki Shunsuke , Inoue Kota , Mihara Yasuhiro , Matsuda Yutaka 
Published: March 2023

AbstractEnzymatic modifications of proteins are of great interest in the pharmaceutical industry as it enables the production of homogeneous protein conjugates such as antibody‐drug conjugates, which are considered to be promising for cancer medicine. Several biotechnology companies have established proprietary conjugation technologies using specific enzymes. Most enzymatic modifications require the use of tags and enzyme‐recognition moieties. Therefore, site‐specific and “tag‐free” modifications are required to avoid the time‐consuming process of installing tags on proteins. Lipoic acid ligase A (LplA), is a recently reported enzyme having the potential to be used for the site‐specific modification of native antibodies without requiring a tag moiety. In this manuscript, investigations focused on the optimization of this enzymatic modification applied to antibody‐drug conjugates (ADCs) production. First, an analysis of the pH dependency was performed. Next, the effects of excess adenosine mono‐ and di‐phosphate were also examined to show that these by‐products from LplA modification did not have a significant impact on inhibiting the reaction efficiency. Furthermore, ADC syntheses by LplA‐mediated tag‐free modification followed by click reaction were achieved. To the best of our knowledge, this is the first example of actual ADC synthesis produced by LplA modification of tag‐free antibodies. A stability assessment of the resulting ADCs indicated that this enzymatic approach is a promising tool for installing biorthogonal groups to native antibodies for the next generation of ADC manufacturing.
A Novel Coumarin‐Based Fluorescent Probe for Sequential Detection of Al3+ and H2PO4−
Authors: Wang Haibin , Zhang Yang , Xu Yang , Wang Xin , Zeng Junzhu , Xue Lei 
Published: March 2023

AbstractA coumarin‐derived acylhydrazone probe (L) was designed and synthesized for successive detection of Al3+ and H2PO4− in DMSO/H2O solution. The probe L exhibited high selectivity towards Al3+ with visible color change and prominent fluorescence enhancement at 592 nm, while the in situ prepared L‐Al3+ complex could selectively recognize of H2PO4− via fluorescence quenching. The detection limits for Al3+ and H2PO4− were calculated to be 3.4 and 11.0 nM, respectively. The binding ratio of L to Al3+ was obtained as 2 : 1 according to the Job's plot and ESI‐MS while the association constant was determined to be 2.13×104 M−1. Furthermore, the probe L was successfully applied in detection of Al3+ and H2PO4− with test strips and in real water samples.
Arene Diazonium Tetrafluoroborate Salts: Novel Lewis Acid Catalysts for Friedel‐Crafts Alkylation of Indoles with α,β‐Unsaturated Ketones
Authors: Qian Cunwei , Li Xian , Zhang Ming 
Published: March 2023

AbstractIn this study, the Friedel crafts alkylation of indole with α, β‐unsaturated ketones catalyzed by arene diazonium tetrafluoroborate salts is reported for the first time, and the optimal conditions of this reaction were explored. The experimental results show that the optimal conditions employed 10 mol % 2‐(2‐bromophenoxy)phenyl diazonium fluoborate (2) as a catalyst, CH3OH as a solvent, 60 °C as reaction temperature, and 24 h as reaction time. Under these optimized conditions, the reaction of indoles with various α,β‐unsaturated ketones can proceed smoothly to obtain aimed products (8). Yields of these reactions ranged from 60 % to 92 %. The reaction conditions are mild and the reaction operation is simple.