bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of industrial agglomeration on urban green land use efficiency in the Yangtze River Economic Belt
Authors: Wang Jingtong , Han Ping 
Published: January 2023

AbstractAt present, the insufficient supply of land resources has seriously hindered the sustainable development of regional economy. Improving the urban green land use efficiency (UGLUE) has become a key issue on the road to sustainable development. As an important feature of economic development, industrial agglomeration has an impact on the UGLUE that cannot be ignored. This paper uses the Global Malmquist–Luenberger Index (GMLI) to measure UGLUE of 107 cities in the Yangtze River Economic Belt (YREB) from 2007 to 2016, and uses a dynamic panel model (DPM) to empirically analyze the effects of industrial specialization agglomeration and diversification agglomeration on UGLUE. On this basis, the heterogeneous impact of industrial agglomeration in different regions on UGLUE is further discussed. The results illustrate that: (1) The UGLUE shows a general downward trend. (2) Different modes of industrial agglomeration have different impacts on UGLUE. The impact of industrial specialization agglomeration on UGLUE was inverted U-shaped. Industrial diversification agglomeration has a positive effect on UGLUE. (3) The impact of industrial agglomeration in different regions on UGLUE is heterogeneous. The relationship between the industrial agglomeration and UGLUE in the YREB revealed in this paper will provide a reference for promoting UGLUE.
Synthesis and characterization of Se doped Fe3O4 nanoparticles for catalytic and biological properties
Authors: Ahghari Mohammad Reza , Amiri-khamakani Zeinab , Maleki Ali 
Published: January 2023

AbstractIn this study, Se-doped Fe3O4 with antibacterial properties was synthesized using by a coprecipitation method. The chemistry and morphology of the Se doped Fe3O4 nanocomposite were characterized by energy-dispersive X-ray spectroscopy, field-emission scanning electron microscopy, X-ray diffraction, vibrating sample magnetometry, and Brunauer–Emmett–Teller spectroscopy. The antibacterial activity of the Fe3O4/Se nanocomposite was examined against G+ (Gram-positive) and G− (Gram-negative) bacteria, in the order Staphylococcusaureus, Staphylococcussaprophyticus, Pseudomonasaeruginosa, Klebsiellapneumonia, and Escherichiacoli, which are the most harmful and dangerous bacteria. Fe3O4/Se, as a heterogeneous catalyst, was successfully applied to the synthesis of pyrazolopyridine and its derivatives via a one-pot four-component reaction of ethyl acetoacetate, hydrazine hydrate, ammonium acetate, and various aromatic aldehydes. Fe3O4/Se was easily separated from the bacteria-containing solution using a magnet. Its admissible magnetic properties, crystalline structure, antibacterial activity, mild reaction conditions, and green synthesis are specific features that have led to the recommendation of the use of Fe3O4/Se in the water treatment field and medical applications. Direct Se doping of Fe3O4 was successfully realized without additional complicated procedures.
Sign change in c-axis thermal expansion constant and lattice collapse by Ni substitution in transition-metal zirconide superconductor Co1−xNixZr2
Authors: Watanabe Yuto , Arima Hiroto , Usui Hidetomo , Mizuguchi Yoshikazu 
Published: January 2023

AbstractRecently, c-axis negative thermal expansion (NTE) was observed in a CoZr2 superconductor and related transition-metal zirconides. Here, we investigated the structural, electronic, and superconducting properties of Co1−xNixZr2 to achieve systematic control of c-axis NTE and switching from NTE to positive thermal expansion (PTE) by Ni substitution. At x ≤ 0.3, c-axis NTE was observed, and the thermal expansion constant αc approached zero with increasing x. At x = 0.4–0.6, c-axis thermal expansion close to zero thermal expansion (ZTE) was observed, and PTE appeared for x ≥ 0.7. On the superconducting properties, we observed bulk superconductivity for x ≤ 0.6, and bulk nature of superconductivity is suppressed by Ni heavy doping (x ≥ 0.7). For x ≤ 0.6, the evolution of the electronic density of states well explains the change in the superconducting transition temperature (Tc), which suggests conventional phonon-mediated superconductivity in the system. By analyzing the c/a ratio, we observed a possible collapsed transition in the tetragonal lattice at around x = 0.6–0.8. The lattice collapse would be the cause of the suppression of superconductivity in Ni-rich Co1−xNixZr2 and the switching from NTE to PTE.
Comparative genomics and interactomics of polyadenylation factors for the prediction of new parasite targets: Entamoeba histolytica as a working model
Authors: Avila-Bonilla Rodolfo Gamaliel , Velazquez-Guzman Jorge Antonio , Reyes-Zepeda Eimy Itzel , Gutierrez-Avila Jorge Luis , Reyes-López César A , Cisneros-Sarabia Alondra , Saavedra Emma , Lopéz-Sandoval Angel , Ramírez-Moreno Esther , López-Camarillo César , Marchat Laurence A. 
Published: January 2023

Abstract
Protein–protein interactions (PPI) play a key role in predicting the function of a target protein and drug ability to affect an entire biological system. Prediction of PPI networks greatly contributes to determine a target protein and signal pathways related to its function. Polyadenylation of mRNA 3′-end is essential for gene expression regulation and several polyadenylation factors have been shown as valuable targets for controlling protozoan parasites that affect human health. Here, by using a computational strategy based on sequence-based prediction approaches, phylogenetic analyses, and computational prediction of PPI networks, we compared interactomes of polyadenylation factors in relevant protozoan parasites and the human host, to identify key proteins and define potential targets for pathogen control. Then, we used Entamoeba histolytica as a working model to validate our computational results. RT-qPCR assays confirmed the coordinated modulation of connected proteins in the PPI network and evidenced that silencing of the bottleneck protein EhCFIm25 affects the expression of interacting proteins. In addition, molecular dynamics simulations and docking approaches allowed to characterize the relationships between EhCFIm25 and Ehnopp34, two connected bottleneck proteins. Interestingly, the experimental identification of EhCFIm25 interactome confirmed the close relationships among proteins involved in gene expression regulation and evidenced new links with moonlight proteins in E. histolytica, suggesting a connection between RNA biology and metabolism as described in other organisms. Altogether, our results strengthened the relevance of comparative genomics and interactomics of polyadenylation factors for the prediction of new targets for the control of these human pathogens.
Glucuronoyl esterases – enzymes to decouple lignin and carbohydrates and enable better utilization of renewable plant biomass
Authors: Larsbrink Johan , Lo Leggio Leila 
Published: January 2023

Abstract
Glucuronoyl esterases (GEs) are microbial enzymes able to cleave covalent linkages between lignin and carbohydrates in the plant cell wall. GEs are serine hydrolases found in carbohydrate esterase family 15 (CE15), which belongs to the large α/β hydrolase superfamily. GEs have been shown to reduce plant cell wall recalcitrance by hydrolysing the ester bonds found between glucuronic acid moieties on xylan polysaccharides and lignin. In recent years, the exploration of CE15 has broadened significantly and focused more on bacterial enzymes, which are more diverse in terms of sequence and structure to their fungal counterparts. Similar to fungal GEs, the bacterial enzymes are able to improve overall biomass deconstruction but also appear to have less strict substrate preferences for the uronic acid moiety. The structures of bacterial GEs reveal that they often have large inserts close to the active site, with implications for more extensive substrate interactions than the fungal GEs which have more open active sites. In this review, we highlight the recent work on GEs which has predominantly regarded bacterial enzymes, and discuss similarities and differences between bacterial and fungal enzymes in terms of the biochemical properties, diversity in sequence and modularity, and structural variations that have been discovered thus far in CE15.
Perception of Prosody in Hearing-Impaired Individuals and Users of Hearing Assistive Devices: An Overview of Recent Advances
Authors: Karimi-Boroujeni Maryam , Dajani Hilmi R. , Giguère Christian 
Published: January 2023

Purpose:
Prosody perception is an essential component of speech communication and social interaction through which both linguistic and emotional information are conveyed. Considering the importance of the auditory system in processing prosody-related acoustic features, the aim of this review article is to review the effects of hearing impairment on prosody perception in children and adults. It also assesses the performance of hearing assistive devices in restoring prosodic perception.

Method:
Following a comprehensive online database search, two lines of inquiry were targeted. The first summarizes recent attempts toward determining the effects of hearing loss and interacting factors such as age and cognitive resources on prosody perception. The second analyzes studies reporting beneficial or detrimental impacts of hearing aids, cochlear implants, and bimodal stimulation on prosodic abilities in people with hearing loss.

Results:
The reviewed studies indicate that hearing-impaired individuals vary widely in perceiving affective and linguistic prosody, depending on factors such as hearing loss severity, chronological age, and cognitive status. In addition, most of the emerging information points to limitations of hearing assistive devices in processing and transmitting the acoustic features of prosody.

Conclusions:
The existing literature is incomplete in several respects, including the lack of a consensus on how and to what extent hearing prostheses affect prosody perception, especially the linguistic function of prosody, and a gap in assessing prosody under challenging listening situations such as noise. This review article proposes directions that future research could follow to provide a better understanding of prosody processing in those with hearing impairment, which may help health care professionals and designers of assistive technology to develop innovative diagnostic and rehabilitation tools.

Supplemental Material:

https://doi.org/10.23641/asha.21809772
The Development of Alveolar and Alveopalatal Fricatives in French-Speaking Monolingual and Bilingual Children
Authors: Kehoe Margaret , Philippart de Foy Marie 
Published: January 2023

Purpose:
This study conducted a transcription-based and spectral moments' analysis of alveolar and alveopalatal fricatives in monolingual and bilingual French-speaking children, aged 2;6–6;10 (years;months). We measured the percent accuracy of fricatives and investigated whether young children could distinguish alveolar and alveopalatal fricatives on the basis of spectral moments. In addition, we examined which child- (i.e., age, gender, bilingualism, and alveopalatal fricative inventory size) and word/sound-related (i.e., place-of-articulation [PoA], voicing, vowel quality, and word position) factors influenced spectral moments and fricative duration.

Method:

Children (
N
= 89) participated in a picture-naming task in which they produced words containing alveolar /s, z/ and alveopalatal /ʃ, ʒ/ fricatives in word-initial, -medial, and -final positions. The words were transcribed and analyzed acoustically, and the first and third spectral moments (i.e., centroid and skewness) and the duration of fricatives were calculated. The data were subject to mixed-effects linear regression.

Results:
Percent accuracy results indicated effects of age on alveopalatal fricatives and effects of word position on voiced fricatives. Statistical models indicated that age, gender, and alveopalatal fricative inventory size influenced spectral moments. Age and inventory size interacted significantly with PoA. Children as young as age 2;6 distinguished alveopalatal and alveolar fricatives on the basis of centroid but not skewness values. The distinction between the two sets of fricatives increased with age. Bilingual children who spoke languages with greater numbers of alveopalatal fricatives distinguished alveopalatal and alveolar fricatives less well than monolinguals and bilinguals who spoke languages with fewer numbers of alveopalatal fricatives. Girls had higher centroid and lower skewness values than boys. Models also revealed a significant influence of word/sound-related factors (voicing, vowel quality, and word position) on spectral moments and fricative duration.

Conclusions:
Findings indicated that multiple factors influence the spectral moments and duration measures of children's alveolar and alveopalatal fricatives. In particular, we found that spectral moments were sensitive to gender and bilingualism effects.
Multi‐objective particle swarm optimisation of complex product change plan considering service performance
Authors: Zheng Ruizhao , Zhang Yong , Sun Xiaoyan , Wang Faguang , Yang Lei , Peng Chen , Wang Yulong 
Published: January 2023

AbstractDesign change is an inevitable part of the product development process. This study proposes an improved binary multi‐objective PSO algorithm guided by problem characteristics (P‐BMOPSO) to solve the optimisation problem of complex product change plan considering service performance. Firstly, a complex product multi‐layer network with service performance is established for the first time to reveal the impact of change effect propagation on the product service performance. Secondly, the concept of service performance impact (SPI) is defined by decoupling the impact of strongly associated nodes on the service performance in the process of change affect propagation. Then, a triple‐objective selection model of change nodes is established, which includes the three indicators: SPI degree, change cost, and change time. Furthermore, an integer multi‐objective particle swarm optimisation algorithm guided by problem characteristics is developed to solve the model above. Experimental results on the design change problem of a certain type of Skyworth TV verify the effectiveness of the established optimisation model and the proposed P‐BMOPSO algorithm.
Interpreting time-integrated polarization data of gamma-ray burst prompt emission
Authors: Guan R. Y. , Lan M. X. 
Published: January 2023

Aims.With the accumulation of polarization data in the gamma-ray burst (GRB) prompt phase, polarization models can be tested.Methods.We predicted the time-integrated polarizations of 37 GRBs with polarization observation. We used their observed spectral parameters to do this. In the model, the emission mechanism is synchrotron radiation, and the magnetic field configuration in the emission region was assumed to be large-scale ordered. Therefore, the predicted polarization degrees (PDs) are upper limits.Results.For most GRBs detected by the Gamma-ray Burst Polarimeter (GAP), POLAR, and AstroSat, the predicted PD can match the corresponding observed PD. Hence the synchrotron-emission model in a large-scale ordered magnetic field can interpret both the moderately low PDs (∼10%) detected by POLAR and relatively high PDs (∼45%) observed by GAP and AstroSat well. Therefore, the magnetic fields in these GRB prompt phases or at least during the peak times are dominated by the ordered component. However, the predicted PDs of GRB 110721A observed by GAP and GRB 180427A observed by AstroSat are both lower than the observed values. Because the synchrotron emission in an ordered magnetic field predicts the upper-limit of the PD for the synchrotron-emission models, PD observations of the two bursts challenge the synchrotron-emission model. Then we predict the PDs of the High-energy Polarimetry Detector (HPD) and Low-energy Polarimetry Detector (LPD) on board the upcoming POLAR-2. In the synchrotron-emission models, the concentrated PD values of the GRBs detected by HPD will be higher than the LPD, which might be different from the predictions of the dissipative photosphere model. Therefore, more accurate multiband polarization observations are highly desired to test models of the GRB prompt phase.
Impact of opacity effects on chromospheric oscillations inferred from NLTE inversions
Authors: Felipe T. , Socas-Navarro H. 
Published: January 2023

Context. Spectropolarimetric inversions are a fundamental tool for diagnosing the solar atmosphere. Chromospheric inferences rely on the interpretation of spectral lines that are formed under nonlocal thermodynamic equilibrium (NLTE) conditions. In the presence of oscillations, changes in the opacity impact the response height of the spectral lines and hinder the determination of the real properties of the fluctuations.
Aims. We aim to explore the relationship between the chromospheric oscillations inferred by NLTE inversion codes and the intrinsic fluctuations in velocity and temperature produced by the waves.
Methods. We computed numerical simulations of wave propagation in a sunspot umbra with the code MANCHA. We used the NLTE synthesis and inversion code NICOLE to compute spectropolarimetric Ca II 8542 Å line profiles for the atmospheric models obtained as the output from the simulations. We then inverted the synthetic profiles and compared the inferences from the inversions with the known atmospheres from the simulations.
Results. NLTE inversions of the Ca II 8542 Å line capture low-frequency oscillations, including those in the main band of chromospheric oscillations around 6 mHz. In contrast, waves with frequencies above 9 mHz are poorly characterized by the inversion results. Velocity oscillations at those higher frequencies exhibit clear signs of opacity fluctuations; namely the power of the signal at constant optical depth greatly departs from the power of the oscillations at constant geometrical height. The main response of the line to velocity fluctuations comes from low chromospheric heights, whereas the response to temperature shows sudden jumps between the high photosphere and the low chromosphere. This strong variation in the height where the line is sensitive to temperature is revealed as a strong oscillatory power in the inferred fluctuations, which is much stronger than the actual power from the intrinsic temperature oscillations.
Conclusions. Our results validate the use of NLTE inversions to study chromospheric oscillations with frequencies below ∼9 mHz. However, the interpretation of higher-frequency oscillations and the power of temperature oscillations must be addressed with care, as these exhibit signatures of opacity oscillations.
Long/Post Covid im Krankenhaus für Naturheilweisen
unter besonderer Berücksichtigung der
Homöopathie
Authors: Schmidt Robert 
Published: January 2023

ZusammenfassungIm Krankenhaus für Naturheilweisen (KfN) wurden seit Beginn der Pandemie
Patienten mit Long/Post Covid behandelt. Letztlich handelt es sich bei
Long/Post Covid sehr wahrscheinlich um die coronavirusspezifische
Variante eines postviralen Chronic-Fatigue-Syndroms, also CFS/ME.
Wirklich durchschlagende, kausal ansetzende Therapien sind noch nicht in Sicht,
sodass man sich aktuell noch darauf beschränken muss, Symptome zu
lindern und den Energielevel der Patienten etwas anzuheben. Für jeden
Patienten wird im KfN ein individuelles Behandlungskonzept zusammengestellt. Aus
konventioneller Sicht ist das KfN eine Fachklinik für Innere Medizin,
zusätzlich werden v. a. klassische Naturheilverfahren und
weitere komplementärmedizinische Behandlungsansätze wie die
ausleitenden Verfahren, Neuraltherapie und eben auch die Homöopathie
angeboten. Der Erfolg unseres Behandlungskonzepts wird durch die eigens
durchgeführte Studie untermauert.
Creating a Guardrail System to Ensure Appropriate Activation of Adolescent Portal Accounts
Authors: Xie James , Hogan Adam , McPherson Tom , Pageler Natalie , Lee Tzielan , Carlson Jennifer 
Published: January 2023

AbstractThe parent of an adolescent patient noticed an upcoming appointment in the patient's portal account that should have remained confidential to the parent. As it turned out, this parent was directly accessing their child's adolescent patient portal account instead of using a proxy account. After investigation of this case, it was found that the adolescent account had been activated with the parent's demographic (i.e., phone/email) information. This case illustrates the challenges of using adult-centric electronic health record (EHR) systems and how our institution addressed the problem of incorrect portal account activations.Confidentiality is fundamental to providing healthcare to adolescents. To comply with the 21st Century Cures Act's information blocking rules, confidential information must be released to adolescent patients when appropriate while also remaining confidential from their guardians. While complying with this national standard, systems of care must also account for interstate variability in which services allow for confidential adolescent consent. Unfortunately, there are high rates of guardian access to adolescent portal accounts which may lead to unintended disclosure of confidential information. Therefore, measures must be taken to minimize the risk of inadvertent confidentiality breaches via adolescent patient portals.Our institution implemented a guardrail system that checks the adolescent patient's contact information against the contact information of their parent/guardian/guarantor. This guardrail reduced the rate of account activation errors after implementation. However, the guardrail can be bypassed when demographic fields are missing. Thus, ongoing efforts to create pediatric-appropriate demographic fields, clearly distinguishing patient from proxy, in the EHR and workflows for registration of proxy accounts in the patient portal are needed.
Comparison of Bisphosphonates Versus Teriparatide in Therapy of the
Glucocorticoid-Induced Osteoporosis (GIOP): A Meta-Analysis of Randomized
Controlled Trials
Authors: Dong Bingzi , Zhou Yue , Wang Jun , Li Chengqian , Fu Zhengju , Huang Yajing , Wang Yangang , Xu Lili 
Published: January 2023

AbstractOsteoporosis (OP) is characterized as decreased bone mineral density (BMD) and
increased risk of bone fracture. Secondary OP resulting from excess endogenous
or exogenous glucocorticoid is defined as glucocorticoid-induced osteoporosis
(GIOP). Current therapeutic strategies for GIOP are similar to menopausal
osteoporosis, including calcium and vitamin D supplementation, bisphosphonates,
and parathyroid hormone (PTH) analogues (teriparatide). Previously, several
published meta-analyses compared anti-osteoporotic agents for the menopausal or
aging-dependent OP. However, the physiopathologic bone metabolism of GIOP is
different. In this study, we investigated the efficacy of BMD enhancement, bone
fracture rate and safety of bisphosphonates versus teriparatide in the therapy
of GIOP. We searched databases including PubMed, Embase, and the Cochrane
Library until Jan 2023, and selected ten random clinical trials (RCT)s that
compared the efficacy and/or safety of bisphosphonate versus
teriparatide for GIOP patients. Teriparatide therapy increased lumber spinal BMD
by 3.96% (95% CI 3.01–4.9%, p<0.00001),
1.23% (95% CI 0.36–2.1%, p=0.006) at
total hip, and 1.45% (95% CI 0.31–2.58%,
p=0.01) at femoral neck, respectively, compared to bisphosphonates at
18-month therapy for GIOP. Teriparatide also reduced bone fracture especially in
vertebral bone (p=0.0001, RR 6.27, 95% CI 2.44–16.07),
and increased bone formation and resorption marker levels. There was no
difference in the incidence of adverse effects in bisphosphonate and
teriparatide groups. Teriparatide showed better performance over bisphosphonate
in BMD enhancement, bone fracture reduction, and bone remodeling improvement,
without increasing the incidence of adverse effects.