bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengetahuan dan Kecemasan pada Lansia terhadap COVID-19
Authors: Korengkeng Loura Caroline , Londok Cornelia 
Published: May 2023

The anxiety experienced by the elderly as cases of COVID-19 increase is related to knowledge, because good and correct knowledge needed to manage all the information. The aim of this study is to find out the relationship between the level of knowledge and the level of anxiety of the elderly about COVID-19 in Suwaan Village, North Minahasa. A cross-sectional study was conducted in May 2021 in which sampling technique used was a total sampling technique with a total of 51 respondents. The instrument used is a questionnaire scale of knowledge and anxiety levels of coronavirus. The results indicate that the level of knowledge of the respondents was in the moderate category with a total of 29 respondents (56.9%). While the anxiety level of the elderly was mostly in the severe category with a total of 42 respondents (82.4%). The data were analyzed using the SPSS and presented in the form of a frequency distribution table and Spearman's rho. It was found that there was no significance relationship between the level of knowledge and the level of anxiety in the elderly in Suwaan Village with p-value = 0.922. It is recommended that the government to actively giving health promotion about COVID-19 and for family members to play an active role in providing correct information, show attention physically, emotional support and psychological support to the elderly in reducing anxiety and to have good knowledge.
Abstrak
Kecemasan yang dialami lansia seiring meningkatnya kasus COVID-19 berkaitan dengan pengetahuan, karena diperlukan pengetahuan yang baik dan benar untuk mengelola semua informasi yang beredar. Penelitian ini bertujuan untuk mengetahui apakah ada hubungan antara tingkat pengetahuan dan tingkat kecemasan lansia terhadap COVID-19 di Desa Suwaan, Minahasa Utara. Metode yang digunakan adalah korelasi deskriptif dengan pendekatan cross sectional, yang dilakukan pada bulan Mei 2021. Teknik pengambilan sampel menggunakan teknik total sampling dengan jumlah 51 responden. Instrumen yang digunakan adalah kuesioner skala tingkat pengetahuan dan tingkat kecemasan virus corona. Hasil penelitian didapati bahwa tingkat pengetahuan responden berada pada kategori cukup dengan jumlah 29 responden (56,9%). Sedangkan tingkat kecemasan lansia sebagian besar berada pada kategori berat dengan jumlah 42 responden (82,4%). Setelah dilakukan analisis data dan uji Spearman’s rho, ditemukan bahwa tidak terdapat hubungan yang signifikan antara tingkat pengetahuan dengan tingkat kecemasan pada lansia di Desa Suwaan dengan nilai p = 0,922. Direkomendasikan pemerintah setempat untuk mengadakan promosi kesehatan tentang COVID-19 dan anggota keluarga untuk berperan aktif dalam memberikan informasi yang benar, dukungan secara fisik, emosional dan psikologis kepada lansia agar dapat membantu lansia menurunkan tingkat kecemasan dan memiliki pengetahuan yang baik.
Kata kunci : COVID-19, Kecemasan, Pengetahuan
Hubungan Pengetahuan dengan Perilaku Pencegahan Demam Tifoid Pada Mahasiswa Keperawatan
Authors: Bellji Gabriella Alvira , Wulandari Imanuel Sri Mei 
Published: May 2023

Typhoid fever is an acute inflammation of the small intestine caused by Salmonella typhi with symptoms that often appear are fever, abdominal discomfort, no appetite, constipation followed by diarrhea, dry cough, weakness, lethargy, fatigue, and rash with relative bradycardia. The purpose of this study was to determine the picture of the level of knowledge, behavior, prevention of Typhoid fever in nursing students of Adventist University of Indonesia. This research is a quantitative research, with a cross sectional approach method. The technique used was using purposive sampling, so that the sample in this study was 73 students where 17 were men and 56 women. The results showed that the majority of samples had positive preventive behavior with a value of 60.3% and negative preventive behavior with a value of 39.7%. There is also a strong and unidirectional significant relationship between the level of knowledge and prevention behavior of Typhoid fever, where the higher the level of knowledge of a person, the higher the level of preventive behavior. It is recommended for students to continue to adopt a healthy lifestyle in preventing the incidence of typhoid fever.
Abstrak
Demam tifoid adalah peradangan akut pada usus kecil yang disebabkan oleh Salmonella typhi dengan gejala yang sering muncul ialah demam, perut tidak nyaman, tidak nafsu makan, sembelit diikuti diare, batuk kering, lemas, lesu, lelah, dan ruam dengan bradikardia relatif. Tujuan penelitian ini untuk mengetahui gambaran tingkat pengetahuan, perilaku, pencegahan demam tifoid pada mahasiswa keperawatan Universitas Advent Indonesia. Penelitian ini merupakan penelitian kuantitatif, dengan metode pendekatan cross sectional. Teknik yang digunakan adalah menggunakan purposive sampling, sehingga sampel dalam penelitian ini sebanyak 73 mahasiswa dimana 17 laki-laki dan 56 perempuan. Hasil penelitian menunjukkan mayoritas sampel memiliki perilaku pencegahan yang positif dengan nilai 60.3% dan perilaku pencegahan negatif dengan nilai 39.7%. Terdapat hubungan signifikan yang kuat dan searah antara tingkat pengetahuan dan perilaku pencegahan demam tifoid, yang dimana semakin tinggi tingkat pengetahuan seseorang maka akan tinggi pula tingkat perilaku pencegahannya. Direkomnediasi kepada mahasiswa untuk tetap menerapkan pola hidup sehat dalam mencegah kejadian demam tifoid.
Kata Kunci: Demam Tifoid, Perilaku Pencegahan, Tingkat Pengetahuan
La psychiatrie française face aux migrants au milieu du XX e siècle
Authors: Scarfone Marianna 
Published: May 2023

Cet article met en lumière les spécificités et les transformations des paradigmes et des pratiques de la psychiatrie française au contact du phénomène migratoire au XX e siècle, à partir de dossiers cliniques et d’articles rédigés par des médecins. En observant d’un côté la permanence de certains éléments hérités du regard colonial, et de l’autre les premiers pas d’une approche plus sociale et moins stigmatisante de la « souffrance immigrée », il propose un premier bilan de la rencontre des patients immigrés avec les dispositifs psychiatriques français dans les années 1950.
Contester le genre et la colonialité
Authors: Nabaneh Satang , Andam Kuukuwa , Odada Kerigo , Eriksson Åsa , Stevens Marion 
Published: May 2023

Au cours de la dernière décennie, a émergé un mouvement hétéroclite œuvrant à réduire les progrès réalisés en matière de santé, de droits sexuels et reproductifs et d’égalité des sexes dans les pays africains. Composé en partie d’organisations occidentales ultraconservatrices ayant des liens transnationaux étroits, il conçoit des campagnes, désigne des portes-paroles locaux, met en place des bureaux satellites, et fournit financements et formations. Les objectifs de ce mouvement sont généralement la révocation du droit à l’avortement, des droits des LGBTQI et d’une éducation sexuelle complète, ayant des conséquences négatives considérables sur les communautés queer , les femmes et les jeunes. Cet article explore les expressions contemporaines que prennent au Ghana, en Afrique du Sud et au Kenya cette résistance globale et interconnectée. À partir d’une analyse critique des discours décoloniaux mobilisés par des figures conservatrices africaines influencées par les débats politiques en circulation depuis les années 1990, il explique pourquoi la notion d’« idéologie du genre » n’est pas un principe structurant essentiel des luttes contre les droits sexuels et reproductifs dans les trois contextes nationaux étudiés.
Doleo ergo sum
Authors: Granek Michel 
Published: May 2023

La douleur chronique parasite deux fois : l’organe atteint et le sujet. Corps étranger, elle s’infiltre dans le corps propre et le rend à son tour étranger. La douleur est censée être un signal d’alarme à la source de stratégie de décision ; dans la douleur chronique, l’alarme déréglée fonctionne en continu. De parasite elle est devenue commensale, le sujet est douleur. Freud a eu du mal à discourir sur la douleur, qu’il définit comme une effraction de l’appareil psychique, et /ou comme une réaction à la perte d’objet. Il en parle aussi comme d’une pseudo-pulsion exigeant un travail de l’appareil psychique. De ce fait, contrairement à certaines coutumes qui différencient la douleur physique de la douleur psychique, je propose de considérer la douleur comme toujours et psychique et physique, située variablement sur un continuum somatopsychique. La douleur chronique qui s’installe sur le tard exige un travail de mort : le sujet réagit à une perte d’objet double, perte de la fonction de l’organe douloureux, et perdition de la vitalité.
S’approprier la Lune ?
Authors: Saint-Martin Arnaud 
Published: May 2023

Cet article propose de retracer l’histoire longue des tentatives de constituer la Lune et ses ressources comme biens appropriables, depuis le champ de l’astronautique états-unienne. L’objectif des avocats de la propriété dans le milieu de l’espace a consisté à contredire l’un des articles du Traité de l’espace de 1967, lequel définit les ressources et corps célestes de l’espace extra-atmosphérique comme « biens communs de l’humanité » non appropriables. Depuis les années 1970 jusqu’aux années 2010, les entrepreneurs états-uniens de l’économie de marché lunaire n’ont cessé de projeter une vision libérale – puis néolibérale – de la propriété de la Lune, en passe de s’imposer alors que le retour sur la Lune paraît plausible dans la décennie 2020 qui s’ouvre. On documentera ces vues du capitalisme spatial sans pour autant prendre au mot ni à la lettre les projets de cette économie privatisée de la Lune, car l’enthousiasme des partisans de la « colonisation » entrepreneuriale du satellite naturel de la Terre est à relativiser par le caractère encore utopique de cette entreprise.
Quand les plateformes s'invitent dans l’audiovisuel français
Authors: Zarka Samuel 
Published: May 2023

L’arrivée des plateformes de streaming par abonnement s’est présentée en France comme une promesse : celle de soutenir localement des showrunners , c’est-à-dire des auteurs-producteurs, porteurs de projets esthétiques ambitieux, susceptibles d’une diffusion internationale. Cet article interroge la mesure dans laquelle cette promesse est tenue, en partant de la fabrication de « séries originales Netflix ». Cela nous conduit à mettre en évidence une densité organisationnelle, qui bouscule les modalités de production établies et interroge les conditions mêmes de l’efficacité productive.
Myelin histology: a key tool in nervous system research
Authors: García-García Óscar Darío , Carriel Víctor , Chato-Astrain Jesús 
Published: May 2023

Abstract
The myelin sheath is a lipoprotein-rich, multilayered structure capable of increasing conduction velocity in central and peripheral myelinated nerve fibers. Due to the complex structure and composition of myelin, various histological techniques have been developed over the centuries to evaluate myelin under normal, pathological or experimental conditions. Today, methods to assess myelin integrity or content are key tools in both clinical diagnosis and neuroscience research. In this review, we provide an updated summary of the composition and structure of the myelin sheath and discuss some histological procedures, from tissue fixation and processing techniques to the most used and practical myelin histological staining methods. Considering the lipoprotein nature of myelin, the main features and technical details of the different available methods that can be used to evaluate the lipid or protein components of myelin are described, as well as the precise ultrastructural techniques.
One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo
Authors: Feng Lin , Li Da , Tian Yao , Zhao Chengshun , Sun Yun , Kou Xiaolong , Wu Jun , Wang Liu , Gu Qi , Li Wei , Hao Jie , Hu Baoyang , Wang Yukai 
Published: May 2023

Abstract

JOURNAL/nrgr/04.03/01300535-202402000-00041/inline-graphic1/v/2023-07-19T141749Z/r/image-tiff

Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson’s disease. Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson’s disease. However, transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche. Here, we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells. These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion, effectively maintaining axonal integrity in vitro. Importantly, midbrain dopaminergic progenitor cell bead grafts showed increased survival and only mild immunoreactivity in vivo compared with suspended midbrain dopaminergic progenitor cell grafts. Overall, our findings show that these midbrain dopaminergic progenitor cell beads enhance the effectiveness of neuronal cell transplantation.
Mucopolysaccharidosis type IIIB: a current review and exploration of the AAV therapy landscape
Authors: Rouse Courtney J. , Jensen Victoria N. , Heldermon Coy D. 
Published: May 2023

Abstract
Mucopolysaccharidoses type IIIB is a rare genetic disorder caused by mutations in the gene that encodes for N-acetyl-alpha-glucosaminidase. This results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological dysfunction. Current treatment options are expensive, limited, and presently there are no approved cures for mucopolysaccharidoses type IIIB. Adeno-associated virus gene therapy has significantly advanced the field forward, allowing researchers to successfully design, enhance, and improve potential cures. Our group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels, auditory function, and lifespan in the murine model for mucopolysaccharidoses type IIIB to that seen in healthy mice. Here, we review the current state of the field in relation to the capsid landscape, adeno-associated virus gene therapy and its successes and challenges in the clinic, and how novel adeno-associated virus capsid designs have evolved research in the mucopolysaccharidoses type IIIB field.
Evaluation of stress and deformation in bone with titanium, CFR-PEEK and zirconia ceramic implants by finite element analysis
Authors: Mahalakshmi G. , Gasthi Anjaneyulu , Hosain Almansour HM , Babaji P , Rao Madhusudhana U , Haseeb SA , Ramaiah Venkata V 
Published: May 2023

Background:
As more recent implant biomaterials, Zirconia ceramic and glass or carbon fibre reinforced PEEK composites have been introduced. In this study, bone stress and deformation caused by titanium, carbon fiber-reinforced polyetheretherketone (CFRPEEK), and zirconia ceramic implants were compared.

Materials and Methods:
In this in vitro finite element analysis study, a geometric model of mandibular molar replaced with implant supported crown was generated. The study used an implant that was 5 mm diameter and 11.5 length. Three implant assemblies made of CFR- polyetheretherketone (PEEK), zirconium, and titanium were created using finite element analysis (FEM). On the implant's long axis, 150 N loads were applied both vertically and obliquely. ANSYS Workbench 18.0 and finite element software were used to compare the Von Mises stresses and deformation produced with a significance level of P < 0.05.

Results:
With no discernible differences, all three implant assemblies that is CFR-PEEK, titanium, and zirconia demonstrated similar stresses and deformation in bone.

Conclusion:
It was determined that zirconia and PEEK and reinforced with carban fibres (CFR-PEEK) can be used as titanium-free implant biomaterial substitutes.
Effects of Prophylactic Bolus of Norepinephrine versus Phenylephrine on Maternal and Fetal Outcome during Caesarean Section under Subarachnoid Block
Authors: Gupta Anjeleena Kumar , Sinha Shweta , Gera Anjali , Marwaha Ashwin , Sood Jayashree 
Published: May 2023

Background:
Vasopressors are the mainstay of treatment of subarachnoid block-induced hypotension (SAIH). The literature is ambiguous regarding the choice of vasopressor, the strategy of administration, and their potency ratio for proper comparison. A prophylactic bolus dosing is the preferred mode of administration for obstetric anesthesia. Thus, we undertook a study to assess the efficacy of norepinephrine (NE) and phenylephrine (PE) in preventing SAIH and compare their effects on maternal and fetal outcomes.

Materials and Methods:
A randomized, double-blind clinical study was conducted on 240 parturients planned for elective cesarean section under subarachnoid block (SAB). They were allocated to receive a prophylactic bolus dose of either NE 4 μg or PE 50 μg immediately after the SAB. The incidence of maternal hypotension (primary outcome); heart rate (HR), reactive hypertension, intraoperative nausea or vomiting, neonatal APGAR score, umbilical umblical cord blood pH, and the need for active neonatal resuscitation (secondary outcomes) was compared between the groups.

Results:
The incidence of hypotension was comparable between the groups (P = 0.42). The mean HR was significantly higher in the NE group at 2 min (83.9 ± 9.2 vs. 80.6 ± 9.3 bpm, P = 0.005), 3 min (84.4 ± 8.8 vs. 79.3 ± 11.1 bpm, P < 0.001) and 4 min (85.0 ± 9.9 vs. 79.6 ± 12.6 bpm, P < 0.001). Rest of the maternal and fetal outcomes were similar in both the groups.

Conclusion:
Based on the relative potency ratio of 12.5, the effect of an intermittent prophylactic bolus dose of NE is comparable to that of PE in preventing SAIH.
Assessment of Flexural and Compressive Strengths of EQUIA, GC Gold Hybrid, and Conventional GIC Restorative Materials
Authors: Joshi Keyur H , Gonapa Prasanthi , Tiriveedi Rishitha , Chowdhury Dibyendu Dam , Aggarwal Anurag , Mishra Samvit , Babaji Prashant 
Published: May 2023

ABSTRACT

Objectives:
This in vitro research was performed to assess the flexural and compressive strengths of EQUIA, GC Gold Hybrid (GH), and conventional glass ionomer cement (GIC) restorative materials. Materials and methods: This study compares three restorative

Materials:
group I—EQUIA Forte GIC, group II—GC GH, and group III—conventional GIC for compressive and flexural strength evaluation. With a specially made Teflon mold, thirty-six cylindrical test specimens measuring 4 mm × 5 mm in dimension were created. They were then placed in 20 mL of deionized water and kept at 37°C for 3 hours every day for 30 days. Later, they were subjected to compressive strength and flexural strength using the universal testing machine. Statistics were used to examine each and every result.

Result and Conclusion:
EQUIA had the highest average compressive strength and flexural strength, whereas traditional GIC restorative material had the lowest.
Conjunctival flora in vernal keratoconjunctivitis
Authors: Mahapatra Ankita , Behera Sharmistha , Behera Sulin Kumar , Dora Jayshree 
Published: May 2023

Aim:
To identify the association of normal bacterial flora with conjunctival flora in vernal keratoconjunctivitis (VKC).

Materials and Methods:
This was a cross-sectional, comparative, hospital-based study over a period of 2 years involving 264 eyes of 132 clinically diagnosed VKC as cases and 264 eyes of 132 patients who came for refractive correction and regular eye check-up as controls. Patients were enquired about medical, treatment, personal, and family history. Routine ophthalmological tests were conducted. Conjunctival specimens were collected, cultured, and identified following standard methods. The association between the presence of bacteria in normal flora and VKC was analyzed using Chi-square statistic.

Results:
Comparable bacterial growth was observed in VKC (77.8%) as well as control group (74.3%) (P = 0.44). Analysis of individual bacteria revealed that Staphylococcus aureus was detected more frequently in VKC, 25% versus 11% in control, P < 0.0001, while Staphylococcus epidermidis was found much more commonly in the control eyes, 39.4% versus 28% in VKC, P = 0.0056.

Conclusion:
A possible aggravating role of S. aureus colonization in the occurrence of VKC and S. epidermidis against the occurrence of VKC was concluded.
Papillary thyroid carcinoma in thyroglossal cyst in a young female
Authors: Vulpala Alekya , Nalla Smitha , Deb Prasun , Mohammed Kashif M. 
Published: May 2023

ABSTRACT
Ectopic thyroid tissue is rare, with a reported incidence of 1 in 300,000. A thyroglossal duct cyst is the most common developmental anomaly of the thyroid gland. The probability of carcinoma arising in such tissue is <1%. The incidence of papillary carcinoma of the thyroid is more in 30–50 years. Here, we report a case of an 18-year-old female presenting with anterior neck swelling, found to have a thyroglossal cyst, fine-needle aspiration cytology (FNAC) of which showed a cystic mass with sparse epithelial cells. After the Sistrunk surgery, biopsy showed classic papillary carcinoma of the thyroid. She underwent total thyroidectomy followed by thyroxine replacement. Thyroglossal cyst papillary carcinoma of the thyroid is a rare entity in young whose diagnosis is easily missed on FNAC; a thorough examination of the biopsy specimen is required. Management should be considered based on multiple associated factors. Overall, the prognosis of it is very good, with a 5-year survival rate of 95%.
Influência dos Distúrbios do Sono no comportamento da criança
Authors: Potasz Clarisse , Carvalho Luciane BC , Natale Vivian B , Russo Claudia RA , Ferreira Vanessa R , Varela Maria José V , Prado Lucila BF , Prado Gilmar F 
Published: May 2023

Introdução. Os distúrbios do sono (DS) podem aparecer em qualquer fase da vida e podem ser influenciados por fatores culturais, psicológicos e sociais. Há uma estreita relação entre problemas noturnos e as alterações diurnas do comportamento. O objetivo deste estudo foi averiguar hábitos de sono, a prevalência de DS e a relação com o comportamento de crianças. Método. Foram incluídas crianças na faixa etária de 3 a 14 anos. Os pais das crianças responderam a questionários sobre alteração do sono na infância, em duas escolas da zona Sul da cidade de São Paulo. Resultados. Os hábitos de sono mais prevalentes foram: ser acordadas por alguém (43,6%), dividir quarto com outra pessoa (43,6%), sonolência excessiva diurna (14,5%), despertar por ruídos leves durante a noite (14,5%). As crianças mais novas dormiram mais tempo que as mais velhas. Das 36 crianças descritas como tendo sono agitado (65%), 17 apresentaram dificuldades de concentração. Dentre as 24 crianças descritas como “crianças agitadas” (44%), 18 apresentaram sono agitado e 10 roncavam. Conclusão. As crianças que roncaram apresentaram problemas de concentração, sono agitado, agressividade e choro.