bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort
Authors: Gaillet Antoine , Azoulay Elie , de Montmollin Etienne , Garrouste-Orgeas Maité , Cohen Yves , Dupuis Claire , Schwebel Carole , Reignier Jean , Siami Shidasp , Argaud Laurent , Adrie Christophe , Mourvillier Bruno , Ruckly Stéphane , Forel Jean-Marie , Timsit Jean-Francois 
Published: March 2023

Abstract
Purpose
Despite antiviral therapy (ART), 800,000 deaths still occur yearly and globally due to HIV infection. In parallel with the good virological control and the aging of this population, multiple comorbidities [HIV-associated-non-AIDS (HANA) conditions] may now be observed.

Methods
HIV adult patients hospitalized in intensive care unit (ICU) from all the French region from university and non-university hospital who participate to the OutcomeRea™ database on a voluntary basis over a 24-year period.

Results
Of the 24,298 stays registered, 630 (2.6%) were a first ICU stay for HIV patients. Over time, the mean age and number of comorbidities (diabetes, renal and respiratory history, solid neoplasia) of patients increased. The proportion of HIV diagnosed on ICU admission decreased significantly, while the median duration of HIV disease as well as the percentage of ART-treated patients increased. The distribution of main reasons for admission remained stable over time (acute respiratory distress > shock > coma). We observed a significant drop in the rate of active opportunistic infection on admission, while the rate of active hemopathy (newly diagnosed or relapsed within the last 6 months prior to admission to ICU) qualifying for AIDS increased—nonsignificantly—with a significant increase in the anticancer chemotherapy administration in ICU. Admissions for HANA or non-HIV reasons were stable over time. In multivariate analysis, predictors of 60-day mortality were advanced age, chronic liver disease, past chemotherapy, sepsis-related organ failure assessment score > 4 at admission, hospitalization duration before ICU admission > 24 h, AIDS status, but not the period of admission.

Conclusion
Whereas the profile of ICU-admitted HIV patients has evolved over time (HIV better controlled but more associated comorbidities), mortality risk factors remain stable, including AIDS status.
The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes
Authors: Morgan Ryan W. , Berg Robert A. , Reeder Ron W. , Carpenter Todd C. , Franzon Deborah , Frazier Aisha H. , Graham Kathryn , Meert Kathleen L. , Nadkarni Vinay M. , Naim Maryam Y. , Tilford Bradley , Wolfe Heather A. , Yates Andrew R. , Sutton Robert M. ,   the ICU-RESUS and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups, Ahmed Tageldin , Bell Michael J. , Bishop Robert , Bochkoris Matthew , Burns Candice , Carcillo Joseph A. , Dean J. Michael , Diddle J. Wesley , Federman Myke , Fernandez Richard , Fink Ericka L. , Friess Stuart H. , Hall Mark , Hehir David A. , Horvat Christopher M. , Huard Leanna L. , Maa Tensing , Manga Arushi , McQuillen Patrick S. , Mourani Peter M. , Notterman Daniel , Pollack Murray M. , Sapru Anil , Schneiter Carleen , Sharron Matthew P. , Srivastava Neeraj , Tabbutt Sarah , Viteri Shirley , Wessel David , Yates Andrew R. , Zuppa Athena F. 
Published: March 2023

Abstract
Background
Epinephrine is provided during cardiopulmonary resuscitation (CPR) to increase systemic vascular resistance and generate higher diastolic blood pressure (DBP) to improve coronary perfusion and attain return of spontaneous circulation (ROSC). The DBP response to epinephrine during pediatric CPR and its association with outcomes have not been well described. Thus, the objective of this study was to measure the association between change in DBP after epinephrine administration during CPR and ROSC.

Methods
This was a prospective multicenter study of children receiving ≥ 1 min of CPR with ≥ 1 dose of epinephrine and evaluable invasive arterial BP data in the 18 ICUs of the ICU-RESUS trial (NCT02837497). Blood pressure waveforms underwent compression-by-compression quantitative analysis. The mean DBP before first epinephrine dose was compared to mean DBP two minutes post-epinephrine. Patients with ≥ 5 mmHg increase in DBP were characterized as “responders.”

Results
Among 147 patients meeting inclusion criteria, 66 (45%) were characterized as responders and 81 (55%) were non-responders. The mean increase in DBP with epinephrine was 4.4 [− 1.9, 11.5] mmHg (responders: 13.6 [7.5, 29.3] mmHg versus non-responders: − 1.5 [− 5.0, 1.5] mmHg; p < 0.001). After controlling for a priori selected covariates, epinephrine response was associated with ROSC (aRR 1.60 [1.21, 2.12]; p = 0.001). Sensitivity analyses identified similar associations between DBP response thresholds of ≥ 10, 15, and 20 mmHg and ROSC; DBP responses of ≥ 10 and ≥ 15 mmHg were associated with higher aRR of survival to hospital discharge and survival with favorable neurologic outcome (Pediatric Cerebral Performance Category score of 1–3 or no worsening from baseline).

Conclusions
The change in DBP following epinephrine administration during pediatric in-hospital CPR was associated with return of spontaneous circulation.
The association of dietary insulin load and dietary insulin index with body composition among professional soccer players and referees
Authors: Beba Mohammad , Gholizadeh Mohammad , Sharifi Mohammad , Seifbarghi Tohid , Djafarian Kurosh 
Published: March 2023

Abstract
Background
There has been limited research undertaken about the association of dietary insulin load (DIL) and dietary insulin index (DII) with body composition in non-athletic adults, however, to the best of our knowledge No previous study has investigated such an association in an athletic population.

Purpose
The aim of this study was to explore the association of DII and DIL with body compositions in male and female soccer players and referees.

Methods
The cross-sectional study was conducted on 199 professional male and female soccer players and referees. A 147-item semi-quantitative food frequency questionnaire (FFQ) was adopted to congregate the participants’ dietary data. Body composition was measured using InBody to gain a detailed understanding of fat mass, percent body fat (PBF), lean mass, percent muscle mass (PMM), and bone mineral content (BMC). Waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were obtained from all participants. Other body composition parameters include a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), body roundness index (BRI), conicity index (CI), weight-adjusted waist index (WWI) and waist-to-hip-to-height ratio (WHHR) were calculated using a particular defined formula.

Results
Results of multiple linear regression revealed that there is a significant association between DIL and BMI (P = 0.04) in < 18 male soccer players, CI (P = 0.04) and WWI (P = 0.03) in ≥ 18 female soccer players, PBF (P = 0.02), PMM (P = 0.01) and WWI (P = 0.01) in ≥ 18 female soccer players. Nevertheless, no significant associations between DIL and body composition parameters were found in the referees. Additionally, there is a significant association between DII and BMC (P = 0.02) in male soccer referees, however, no significant associations were found in young soccer players and female athletes.

Conclusion
This study demonstrates that DIL is positively associated with BMI, CI, and WWI in male soccer players and PBF, and WWI in female soccer players. Although, there was an observed negative association between DIL and PMM in females. In addition, a significant negative association between DII and BMC was observed in male soccer players.
The existence of discrete solitons for the discrete coupled nonlinear Schrödinger system
Authors: Huang Meihua , Zhou Zhan 
Published: March 2023

AbstractIn this paper, we investigate the nonlinear coupled discrete Schrödinger equations with unbounded potentials. We find simple sufficient conditions for the existence of discrete soliton solution by using the Nehari manifold approach and the compact embedding theorem. Furthermore, by comparing the value of the action functional at the discrete soliton solution with those at nonzero solutions of one component zero, we demonstrate that both components of the discrete soliton solution are nontrivial.
Antimicrobial photodynamic therapy with Ligularia fischeri against methicillin-resistant Staphylococcus aureus infection in Caenorhabditis elegans model
Authors: Ha Ngoc Minh , Hwang Hoseong , Alam Seemi Tasnim , Nguyen Uyen Tran Tu , Lee Soon Kwang , Park Jin-Soo , Kim Jin-Chul , Kwon Hak Cheol , Kwon Jaeyoung , Kang Kyungsu 
Published: March 2023

AbstractThe high prevalence of methicillin-resistant Staphylococcus aureus (MRSA) infection threatens the effectiveness of current clinical settings. Antimicrobial photodynamic therapy (APDT) is a promising alternative to antibiotics for treating infections due to its low resistance. This study aimed to evaluate the antibacterial properties of APDT with L. fischeri extract (LFE) against MRSA and various skin and oral pathogens in vitro and its photopharmaceutical actions in Caenorhabditis elegans. The antimicrobial activities of APDT with LFE against pathogens were evaluated using plate counting method. The chemical profile was characterized using high-performance liquid chromatography and spectrophotometry. The growth rate assay, lifespan assay, and bacterial attachment on worms were performed to assess the therapeutics effects in C. elegans. The swab method was used for the detection of pathogens on the micropig skin surface. The APDT treatment with L. fischeri extract (LFE, 20 µg/mL) and red light (intensity of 120 W/m2) reduced 4.3–4.9 log (colony forming unit/mL) of Staphylococcus aureus, MRSA, Cutibacterium acnes, Streptococcus mutans; and 2.4 log (CFU/mL) of Candida albicans. Chemical analysis revealed that LFE enriched three active photosensitizers. APDT reduced bacterial populations on worms, recovered growth retardation, and improved lifespan in MRSA-infected C. elegans without causing severe side effects. The surface eradication of MRSA after exposure to LFE with red light was demonstrated on micropig skin. These findings highlight the significance of L. fischeri as a natural resource for the safe phototreatment of MRSA infection in the biomedical and cosmeceutical industries.
Association between traumatic brain injury and mental health care utilization: evidence from the Canadian Community Health Survey
Authors: Kureshi Nelofar , Clarke David B. , Feng Cindy 
Published: March 2023

Abstract
Background
Mental health disorders are a common sequelae of traumatic brain injury (TBI) and are associated with worse health outcomes including increased mental health care utilization. The objective of this study was to determine the association between TBI and use of mental health services in a population-based sample.

Methods
Using data from a national Canadian survey, this study evaluated the association between TBI and mental health care utilization, while adjusting for confounding variables. A log-Poisson regression model was used to estimate unadjusted and adjusted prevalence ratios (PR) and 95% confidence intervals (CI).

Results
The study sample included 158,287 TBI patients and 25,339,913 non-injured individuals. Compared with those were not injured, TBI patients reported higher proportions of chronic mental health conditions (27% vs. 12%, p < 0.001) and heavy drinking (33% vs. 24%, p = 0.005). The adjusted prevalence of mental health care utilization was 60% higher in patients with TBI than those who were not injured (PR = 1.60, 95%; CI 1.05–2.43).

Conclusions
This study suggests that chronic mental health conditions and heavy drinking are more common in individuals with TBI. The prevalence of mental health care utilization is 60% higher in TBI patients compared with those who are not injured after adjusting for sociodemographic factors, mental health conditions, and heavy drinking. Future longitudinal research is required to examine the temporality and direction of the association between TBI and the use of mental health services.
Instant formation of horizontally ordered nanofibrous hydrogel films and direct investigation of peculiar neuronal cell behaviors atop
Authors: Park Jaeil , Nguyen Thi Thuy Chau , Lee Su-Jin , Wang Sungrok , Heo Dongmi , Kang Dong-Hee , Tipan-Quishpe Alexander , Lee Won-June , Lee Jongwon , Yang Sung Yun , Yoon Myung-Han 
Published: March 2023

Abstract

Background
Hydrogels have been widely used in many research fields owing to optical transparency, good biocompatibility, tunable mechanical properties, etc. Unlike typical hydrogels in the form of an unstructured bulk material, we developed aqueous dispersions of fiber-shaped hydrogel structures with high stability under ambient conditions and their application to various types of transparent soft cell culture interfaces with anisotropic nanoscale topography.

Method
Nanofibers based on the polyvinyl alcohol and polyacrylic acid mixture were prepared by electrospinning and hydrogelified to nano-fibrous hydrogels (nFHs) after thermal crosslinking and sulfuric acid treatment. By modifying various material surfaces with positively-charged polymers, negatively-charged superabsorbent nFHs could be selectively patterned by employing micro-contact printing or horizontally aligned by applying shear force with a wired bar coater.

Results
The angular distribution of bar-coated nFHs was dramatically reduced to ± 20° along the applied shear direction unlike the drop-coated nFHs which exhibit random orientations. Next, various types of cells were cultured on top of transparent soft nFHs which showed good viability and attachment while their behaviors could be easily monitored by both upright and inverted optical microscopy. Particularly, neuronal lineage cells such as PC 12 cells and embryonic hippocampal neurons showed highly stretched morphology along the overall fiber orientation with aspect ratios ranging from 1 to 14. Furthermore, the resultant neurite outgrowth and migration behaviors could be effectively controlled by the horizontal orientation and the three-dimensional arrangement of underlying nFHs, respectively.

Conclusion
We expect that surface modifications with transparent soft nFHs will be beneficial for various biological/biomedical studies such as fundamental cellular studies, neuronal/stem cell and/or organoid cultures, implantable probe/device coatings, etc.
Potentials and challenges of using co-design in health services research in low- and middle-income countries
Authors: Singh Devendra Raj , Sah Rajeeb Kumar , Simkhada Bibha , Darwin Zoe 
Published: March 2023

AbstractCo-design with people having poor access to health services and fragile health systems in low- and middle-income countries can be momentous in bringing service users and other stakeholders together to improve the delivery and utilisation of health services. There is ample of evidence from high-income countries regarding how co-design can translate available evidence into developing acceptable, feasible, and adaptable health solutions in different settings. However, there is limited literature on co-design in health research in the context of low- and middle-income countries. Therefore, it is crucial to understand how knowledge about collaborative working can be translated into policy and practice in the context of low- and middle-income countries. Thus, this paper discusses the concept of co-design, co-production, and co-creation in health and the potentiality and challenges of using co-design in health services research in low- and middle-income countries. Despite the challenges, the co-design research has considerable potential to encourage the meaningful engagement of service users and other stakeholders in developing, implementing, and evaluating real-world solutions in low- and middle-income countries. It is essential to balance power dynamics in a co-design process through mutual recognition and respect, participant diversity, and reciprocity and flexibility in sharing. The inclusive and collaborative approach to working is complex due to existing rigid hierarchical structures, socio-cultural beliefs, political interference and working practices. However, this could be minimised by developing transparent terms of reference that reflect the value and benefits of equal partnership in particular co-design work.
Patient factors associated with receipt of psychological and pharmacological treatments among individuals with common mental disorders in a Swedish primary care setting
Authors: Cullen Alexis E. , Lindsäter Elin , Rahman Syed , Taipale Heidi , Tanskanen Antti , Mittendorfer-Rutz Ellenor , Helgesson Magnus 
Published: March 2023

Background
Psychological and pharmacological therapies are the recommended first-line treatments for common mental disorders (CMDs) but may not be universally accessible or utilised.

Aims
To determine the extent to which primary care patients with CMDs receive treatment and the impact of sociodemographic, work-related and clinical factors on treatment receipt.

Method
National registers were used to identify all Stockholm County residents aged 19–64 years who had received at least one CMD diagnosis (depression, anxiety, stress-related) in primary care between 2014 and 2018. Individuals were followed from the date of their first observed CMD diagnosis until the end of 2019 to determine treatment receipt. Associations between patient factors and treatment group were examined using multinomial logistic regression.

Results
Among 223 271 individuals with CMDs, 30.6% received pharmacotherapy only, 16.5% received psychological therapy only, 43.1% received both and 9.8% had no treatment. The odds of receiving any treatment were lower among males (odds ratio (OR) range = 0.76 to 0.92, 95% CI[minimum, maximum] 0.74 to 0.95), individuals born outside of Sweden (OR range = 0.67 to 0.93, 95% CI[minimum, maximum] 0.65 to 0.99) and those with stress-related disorders only (OR range = 0.21 to 0.51, 95% CI[minimum, maximum] 0.20 to 0.53). Among the patient factors examined, CMD diagnostic group, prior treatment in secondary psychiatric care and age made the largest contributions to the model (R2 difference: 16.05%, 1.72% and 1.61%, respectively).

Conclusions
Although over 90% of primary care patients with CMDs received pharmacological and/or psychological therapy, specific patient groups were less likely to receive treatment.
The Transcaruncular Corridor of the Medial Transorbital Approach to the Frontal Lobe: Technical Nuances and Applications
Authors: Polster Sean P. , Beale Oliver , Patel Vijay A. , Abou-Al-Shaar Hussam , Stefko S. Tonya , Gardner Paul A. 
Published: March 2023

BACKGROUND AND IMPORTANCE:
Medial orbital access through a transcaruncular corridor has yet to be fully characterized as a potential approach to intradural lesions within the skull base. Transorbital approaches present unique potential in the management of complex neurological pathologies and require subspecialty collaboration across multiple disciplines.

CLINICAL PRESENTATION:
A 62-year-old man presented with progressive confusion and mild left-sided weakness. He was found to have a right frontal lobe mass with significant vasogenic edema. A comprehensive systemic workup was otherwise unremarkable. A multidisciplinary skull base tumor board conference recommended a medial transorbital approach through transcaruncular corridor, which was performed by neurosurgery and oculoplastics services. Postoperative imaging demonstrated gross total resection of the right frontal lobe mass. Histopathologic evaluation was consistent with amelanotic melanoma with BRAF (V600E) mutation. At his last follow-up visit, 3 months after surgery, the patient did not experience any visual symptoms and had an excellent cosmetic outcome after surgery.

CONCLUSION:
The transcaruncular corridor through a medial transorbital approach provides a safe and reliable access to the anterior cranial fossa.
The Effects of an Acute Bout of Aerobic or Resistance Exercise on Nonexercise Physical Activity
Authors: Thomas Jason V. , Tobin Selene Y. , Mifflin Mark Garrett , Burns Ryan D. , Bailey Ryan R. , Purcell Sarah A. , Melanson Edward L. , Cornier Marc-Andre , Halliday Tanya M. 
Published: March 2023

ABSTRACT

Introduction/Purpose
A reduction in nonexercise physical activity (NEPA) after exercise may reduce the effectiveness of exercise interventions on weight loss in adults with overweight or obesity. Aerobic exercise (AEx) and resistance exercise (REx) may have different effects on NEPA. The purpose of this secondary analysis was to examine the effect of a single bout of AEx or REx on NEPA and sedentary behavior in inactive adults with overweight or obesity.

Methods
Adults with overweight or obesity (n = 24; 50% male; age, 34.5 ± 1.5 yr; body mass index, 28.5 ± 0.9 kg·m−2) not meeting current physical activity guidelines completed a single 45-min bout of AEx, REx, or a sedentary control on different days in random order. After each condition, participants’ NEPA was recorded for 84 h by accelerometer. Time spent sedentary and in light, moderate, and vigorous physical activity; steps; metabolic equivalent of task (MET)-hours; and sit-to-stand transitions were calculated using activity count data.

Results
No differences were observed in the percent of waking time spent sedentary and in light, moderate, and vigorous activity between conditions (P > 0.05). No differences were observed in steps, MET-hours, or sit-to-stand transitions between conditions (P > 0.05). NEPA responses were variable among individuals, with approximately half of participants reducing and half increasing NEPA over the 84 h after each exercise condition.

Conclusion
NEPA was not reduced after an acute bout of AEx or REx in a sample of inactive adults with overweight or obesity.
Pembuatan Media Pembelajaran Digital Interaktif untuk Materi Pembelajaran Bahasa Arab (Nahwu dan Shorof) untuk Santri Milenial
Authors: Muklason Ahmad , Riksakomara Edwin , Mahananto Faizal , Djunaidy Arif , Vinarti Retno Aulia , Anggraeni Wiwik , Nurita Raras Tyas , Utamima Amalia , Basara Naufal Rafiawan , Nuriman Muhammad Arif , Jayanty Amalinda , Khofifah Nur , Laila Nur , Mahatta Hanif Mitsal , Ananda M. Fiqri , Wibowo Tristanto Rachmadi , Hisyam Muhammad , Kamil Mochamad Zidan Aqila 
Published: March 2023

Pondok Pesantren adalah lembaga pendidikan tertua di Indonesia. Kurang lebih separuh dari pondok pesantren tesebut adalah pondok pesantren salafiyah, yaitu pesantren yang menerapkan metode tradisional. Sistem pendidikan salafiyah ini menemui tantangan karena santri saat ini adalah santri milenial yang memiliki kecenderungan yang berbeda dan lebih senang belajar menggunakan gadget. Oleh, karena itu kegiatan pengabdian masyarakat ini bertujuan untuk mengembangkan konten pembelajaran digital interaktif dari materi pembelajaran bahasa arab pondok pesantren salaf yaitu pelajaran Nahwu dan Shorof yang saat ini rujukannya adalah kitab kuning. Konten digital ini dikembangkan menggunakan teknologi H5P. Untuk mengetahui tingkat penerimaan santri terhadap konten digital ini, dilakukan Focus Group Discussion, wawancara, dan pengisian kuesioner. Hasil penelitian menunjukkan bahwa 73,7% santri merasa lebih mudah memahami materi dengan menggunakan digital learning, dan 89,7% santri merasa konten digital ini membuat pembelajaran lebih menyenangkan. Secara keseluruhan, platform ini memberikan kemudahan dan pembelajaran menjadi lebih menyenangkan. Akan tetapi, masih terdapat beberapa umpan balik yang dijadikan evaluasi platform dan sistem pembelajaran kedepannya, seperti tidak adanya mentor untuk mendampingi para santri belajar.