bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTIMICROBIAL ACTIVITY OF CINNAMALDEHYDE, VANILLIN AND KIGELIA AFRICANA FRUIT EXTRACTS AGAINST FISH-ASSOCIATED CHRYSEOBACTERIUM AND MYROIDES SPP. ISOLATES
Authors: Chenia Hafizah Yousuf 
Published: June 2023

Background: Members of the family Flavobacteriaceae exhibit intrinsic multi-drug resistance, which hampers their effective eradication. Phytochemicals are being explored as alternatives to the use of antimicrobial agents in aquaculture since they have growth-promoting, immune-stimulating, and antimicrobial properties.
Materials and Methods: The susceptibility of 36 Chryseobacterium and seven Myroides spp. isolates from salmon, tilapia and trout as well as 19 selected Flavobacteriaceae type strains to cinnamaldehyde, vanillin and four crude Kigelia africana extracts (ethyl acetate, dichloromethane, methanol and hexane), was assessed using disc diffusion assays and compared to standard antimicrobial agents, ampicillin and tetracycline using activity indices.
Results: Cinnamaldehyde (≥250 µg/ml) was the most effective (77. 8 – 100% susceptibility) while vanillin was the least effective with inhibitory activity only at 1000 µg/ml. The K. africana hexane extract (4 mg/ml) was the most effective, with only 11.3% of isolates displaying resistance, while 94.4% of isolates demonstrated resistance to ampicillin and 38.9% susceptibility to tetracycline. K. africana extract inhibitory efficacy decreased in the following order: hexane > ethyl acetate > dichloromethane > methanol. Cinnamaldehyde and K. africana EX 4 activity indices ≥ 1 were obtained for 83.3 - 97.2% and 25% of Chryseobacterium spp. isolates, respectively, relative to tetracycline.
Conclusions: Cinnamaldehyde and K. africana fruit hexane extracts are promising candidates to be tested for their efficacy in the treatment of Chryseobacterium/Myroides-associated fish infections. These phytochemicals might serve as environmentally-friendly, cost-effective alternatives to the use of antimicrobial agents in aquaculture farms, with a lesser chance of resistance development.
EFFECTS OF SUPPLEMENTING LACTIC ACID BACTERIA ON FECAL MICROBIOTA, TOTAL CHOLESTEROL,TRIGLYCERIDES AND BILE ACIDS IN RATS.
Authors: Zhimin Jin , Hong-bo Zhang , Xuehui Jia , Qian Yuan , Liga Tong , Yan Duan , Ye Jin 
Published: June 2023

Background: Probiotics (LAB) are normal components of the intestinal micro-flora in both humans and animals and its ingestion in decreasing the risk of atherosclerosis. In addition, the potential health effects of LAB were investigated by monitoring changes in intestinal micro-flora and lipid metabolism in a rat model.
Materials and Methods: Rats were randomly assigned into four treatments and fecal samples were obtained on days 1, 3, 5, 9 and 14,to evaluate fecal micro biota, total cholesterol (TC), triglycerides (TG) and bile acids in rats (TBA).
Results: The results indicated that Lactobacillus plantarum strain L.p X3-2B increased fecal lactic acid bacteria(LAB) and Bifidobacterium while resisting the growth of harmful bacteria. Viable counts of LAB and Bifidobacterium reached 8 log cfu/mL after feeding for 14 days. Fecal pH in the control group was high in comparison with the treatments at all times. Treatment increased the excretion of triglycerides (TG), total cholesterol (TC) and total bile acid (TBA). The results indicate that LAB and Bifidobacterium induce a positive correlation with fecal TC, TG and TBA and a negative correlation with fecal Enterobacteriaceae, Enterococcus and Escherichia coli.
Conclusion: Lactic acid bacteria screened from Inner Mongolia native meat sausages in China had cholesterol-lowering effect.
ACTIVATION OF DIFFERENT CEREBRAL FUNCTIONAL REGIONS FOLLOWING ACUPUNCTURE AT BOT H TAIXIAND TAICHONG ACUPOINTS AND TAIXIACUPOINT ALONE: AN FMRI STUDY
Authors: Wang Y. J. , Zheng Y. , Zhang G. F. , Zhan J. P. , Wu C. X. , Zhang S. Q. , Ouyang H. L. , Li Z. P. , Chen J. R. , Qu S. S. , Chen J. Q. , Huang Y. , Tang C. Z. 
Published: June 2023

Background: To explore the brain function regions characteristics of the acupoint combination, this study observed activity changes in the brain
regions of healthy volunteers after acupuncture at both Taixi (KI3) and Taichong (LR3) (KI3 + LR3) and KI3 alone using resting-state functional
magnetic resonance imaging(fMRI).
Methods: 30 healthy volunteers were randomly allocated into two groups, one group received acupuncture at KI3 and LR3, the other only
acupuncture at KI3, 15 cases in each group. All volunteers underwent resting-state fMRI of the brain 15 minutes before acupuncture, and which
the needle was retained in place for 30 minutes; 15 minutes after withdrawing the needle underwent a further session of resting-state fMRI. The
amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were used to analyze the changes in brain regions.
Results: The KI3+LR3 group compared with the KI3 group, the ALFF analysis indicated that the brain changes relatively concentrated in BA 2,
3, 7, 8, 9, 10, 18, 19, 20, 31, 32, 40, 46 and the cerebellum posterior lobe, the ReHo analysis indicated that the brain changes relatively
concentrated in BA 4, 6, 7, 10, 11, 18, 19, 20, 21, 22, 31, 40 and the cerebellum posterior lobe.
Conclusion: Based on this study, compared with acupuncture at KI3, acupuncture at KI3 + LR3 which could specifically influence BA 7, 10, 18,
19, 20, 31, 40 and cerebellum posterior lobe, which may be related to synergy mechanism of two acupoints combination treatment.
ASTRAGALOSIDE IV LIPOSOMES AMELIORATES ADRIAMYCIN-INDUCED NEPHRITIC SYNDROME IN RATS MING-GANG
Authors: Wei Ming-gang , He Wei-ming , Zhang Ling , Yan Zhao-wei , Yang Yan-Yu , Xiong Pei-Hua , Sun Wei 
Published: June 2023

Background: Radix Astragali was one of the main composition of ‘Modified Danggui Buxue Decoction’ used for treatment of various kidney
diseases. Astragaloside IV was the active composition of Radix Astragali. Astragaloside IV liposomes were used for the treatment of
adriamycin-induced nephropathy (AN) rats. The aim of the study was to study the effect of astragaloside IV liposomes on AN rats, and to test
through regulating the expression of nephrin, integrins and integrin-linked kinase (ILK) in renal tissues.
Methods: The rats were given a single tail intravenous injection of adriamycin (6 mg/kg) within 1 weeks, and then divided into four groups
including normal, model, benazepril and astragaloside IV liposomes group. They were all orally administered dosage of benazepril and
astragaloside IV liposomes once daily for 8 weeks.
Results: Astragaloside IV liposomes significantly reduced the proteinuria of AN rats at 28, 42 and 56 days. astragaloside IV liposomes could
increase the mRNA and protein expression of nephrin, integrin α3, down-regulate the expression of ILK to alleviate the podocyte damage and
restore glomerular selective filtration function.
Conclusions: Astragaloside IV liposomes could enhance renal function and protect podocyte to ameliorate the adriamycin-induced nephritic
syndrome.
PHYTOCHEMICAL ANALYSIS OF CYRTANTHUS OBLIQUUS BULBS FROM THE INFORMAL STREET MARKET OF KWAZULU-NATAL, SOUTH AFRICA
Authors: Mahlangeni Nomfundo T. , Moodley Roshila , Jonnalagadda Sreekanth B. 
Published: June 2023

Background: Cyrtanthus obliquus is a medicinal plant commonly known by the locals in South Africa as Umathunga. It is used in traditional South
African medicine for the treatment of scrofula, chronic coughs and headaches and is also used to prepare the popular decoction known as Imbiza.
Materials and methods: The secondary metabolites from C. obliquus bulbs were extracted using solvent extraction techniques, isolated using
column chromatography and identified using spectroscopic techniques. The antioxidant potential of the isolated compounds was determined by the
2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and the ferric reducing antioxidant potential (FRAP) assay.
Results: The extracts yielded four homoisoflavonoids, 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzyl)chroman-4-one, 5,7-dihydroxy-3-(4ꞌ-
hydroxybenzyl)chroman-4-one,5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzylidene)chroman-4-one and 5,7-dihydroxy-3-(4ꞌ-
hydroxybenzylidene)chroman-4-one. An unusual 3-β-glucopyranosyl-22,27-dihydroxy-lanosta-8-ene was also isolated from the bulbs. The
antioxidant studies showed that 3-benzylchromanones have better activity than 3-benzylidenechromanones.
Conclusion: Four homoisoflavanones namely 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzyl)chroman-4-one; 5,7-dihydroxy-6-methoxy-3-(4ꞌ-
hydroxybenzyl)chroman-4-one and two 5,7-dihydroxy-6-methoxy-3-(4ꞌ-methoxybenzylidene)chroman-4-one; 5,7-dihydroxy-3-(4ꞌ-
hydroxybenzylidene)-chroman-4-one were obtained from Cyrtanthus obliquus.
CYTOLOGICAL EFFECTS OF PULSED ELECTROMAGNETIC FIELDS AND STATIC MAGNETIC FIELDS INDUCED BY A THERAPEUTIC DEVICE ON IN VIVO EXPOSED RATS.
Authors: Rodriguez de la Fuente Abraham Octavio , Heredia-Rojas Jose Antonio , Carranza-Rosales Pilar , Heredia-Rodriguez Omar , Lozano-Garza Gerardo , Zavala-Pompa Angel , Rodriguez-Flores Laura E. 
Published: June 2023

Background: There is a trend towards the use of magnetic fields in medicine. Pulsed electromagnetic fields (PEMFs) technology was based
upon 20 years of fundamental studies on the electromechanical properties of bone and other connective tissues. More recently, these magnetic
fields have been used to treat several health conditions. There remains continuing concern that exposure to electromagnetic devices may cause
adverse effects. The aim of the present study was to investigate the cytological effects induced in rats exposed in a patented medical device that
uses PEMFs combined with static magnetic fields (SMFs).
Material and Methods: Thirty sexually mature 14-week-old male and female Sprague Dawley rats were distributed into three groups: (a) 5
males and 5 females (independently) exposed to PEMFs combined with SMFs, (b) animals treated with SMFs only, and (c) non-exposed
animals. Acridine orange fluorescent-staining micronucleus test and male germ cells analysis were performed according to standardized
techniques.
Results: A lack of evidence for alterations on micronucleus frequency, on polychromatic erythrocytes percentage, and on sperm counts and
morphological characteristics of male germ cells were found in mature rats exposed to PEMFs medical device compared to non-exposed
animals.
Conclusions: This study suggests that the applied magnetic field generated in a therapeutic device did not have any detectable cytotoxic or
genotoxic effect in exposed rats. In view of these findings and the contradictory reports in the literature, it is necessary to carry out more
research to help clarify the controversy concerning cytogenotoxic risk associated with therapeutic magnetic fields exposures.
SIJUNZI DECOCTION DEMOLITION PARTIES INHIBIT PROLIFERATION AND INDUCE APOPTOSIS OF HUMAN GASTRIC CANCER BGC823 SIDE POPULATION
Authors: Qian Jun , Xie Hui , Guo Chenxu , Sun Rui , Su Lin , Jia Jianguang , Jin Xin , Yu Dajun , Li Jing 
Published: June 2023

Background: Comprehensive treatment combining with Chinese medicine has become the main therapeutic regimen of gastric cancer. Previous
evidence demonstrated SD can enhance the effect of chemotherapy in advanced cancer, especially in gastric cancer. In order to investigate the
anticancer mechanism of SD in gastric cancer, we observed the effects of SD parties (Ginseng, Atractylodes, Poria, Licorice) on proliferation and
apoptosis of SP of human gastric cancer BGC-823.
Materials and Methods: 1. BGC-823 side population cells were sorted through flow cytometry. 2. To detect the changes of proliferation of SP
and NSP before and after the intervention of serum containing SD parties using cck-8 method. 3. To detect the changes of cell cycle and
apoptosis of SP and NSP before and after the intervention of serum containing SD parties through flow cytometry. 4. To detect the effects of
serum containing SD parties on apoptosis-related proteins Bax and Bcl-2 of SP and NSP before and after the intervention by western-blot.
Results: It was found that four demolition parties serum treatments inhibited cell proliferation in a time-dependent manner. Compared with the
control group (normal saline treatment), there were increase in G1/G0 phase population of SP and NSP, and decrease in G2/M and S phase
population (P
Distribution and Cocrystallization Coefficients of a Wide Range of Typomorphic Elements in Magnetite, Hematite, and Sphalerite in Hydrothermal Systems
Authors: Tauson V.L. , Lipko S.V. , Smagunov N.V. , Babkin D.N. , Belozerova O.Yu. 
Published: June 2023

Abstract
—Distribution of a wide range of elements in the systems with magnetite, hematite and sphalerite is studied by the method of thermogradient hydrothermal synthesis combined with internal fluid sampling at 450 °C temperature and 100 MPa pressure. The distribution and cocrystallization coefficients are determined; the literature and original data on these coefficients are summarized. The possibility of obtaining the reproducible data on elements distribution in the mineral − solution system in the occurrence of many typomorphic elements is substantiated. This considerably increases the experiment efficiency. A significant advantage of using cocrystallization coefficients rather than “conventional” distribution coefficients expressed by the ratio of the element concentrations in crystal and solution (fluid) is shown. The features of behavior and occurrence of elements in hydrothermal systems are provided with physico-chemical evidence, through application of cocrystallization coefficients. The examples of the behavior of typomorphic trace elements in sphalerite are considered, which support the theoretical analysis. The major (Fe, Mn, Zn and possibly Cu) and secondary (Ti, V, Al, and Co) components of ore-forming solutions are estimated according to the compositions of magnetite and hematite from hydrothermal ore deposits of various types. The similarity in compositions of magnetite and hematite does not prove their coformation from a single fluid, quite the reverse, and this fact indicates different compositions of fluids from which the minerals were deposited.
Temperature-responsive crystal dynamic accelerates sieving of propane/propylene mixtures
Authors: Huang Yuhang , Wan Jingmeng , Lu Zhiyong , Ge Kai , Pan Ting , Guo Yanan , Bai Junfeng , Jin Wanqin , Kitagawa Susumu , Duan Jingui 
Published: June 2023

Abstract
Soft nanoporous crystals with structural dynamics are among the most exciting of recently discovered materials. However, designing or controlling this system, which can recognize very similar gases, remains a challenge. Here we report a soft crystal (NTU-68) in which one-dimensional channel opening delicately expands and contracts ~4 Å at elevated temperature. A completely different adsorption model for propane (C3H8: kinetic dominance) and propylene (C3H6: thermodynamic preference) allows sieving of C3H8/C3H6 mixtures at 273 K (10 min·g-1), as well as boosted performance at 298 K (22 min·g-1). This is contrary to the general observation for adsorption separation, the higher the temperature, the lower the efficiency. Gas-loaded in-situ powder X-ray analysis and model calculations reveal that slight pore enlargement in the temperature response provides plausible traffic for C3H6 but remains constriction on C3H8. The finely controlled dynamic systems and efficient molecular recognition provide a new route for design of next-generation sieve materials.
Direct Prediction Of Intrinsically Disordered Protein Conformational Properties From Sequence
Authors: Lotthammer Jeffrey , Ginell Garrett , Griffith Daniel , Emenecker Ryan , Holehouse Alex 
Published: June 2023

Abstract
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a range of functional roles. While folded domains are generally well-described by a single 3D structure, IDRs exist in a collection of interconverting states known as an ensemble. This structural heterogeneity means IDRs are largely absent from the PDB, contributing to a lack of computational approaches to predict ensemble conformational properties from sequence. Here we combine rational sequence design, large-scale molecular simulations, and deep learning to develop ALBATROSS, a deep learning model for predicting IDR ensemble dimensions from sequence. ALBATROSS enables the instantaneous prediction of ensemble average properties at proteome-wide scale. ALBATROSS is lightweight, easy-to-use, and accessible as both a locally installable software package and a point-and-click style interface in the cloud. We first demonstrate the applicability of our predictors by examining the generalizability of sequence-ensemble relationships in IDRs. Then, we leverage the high-throughput nature of ALBATROSS to characterize emergent biophysical behavior of IDRs within and between proteomes.
Prevalence and Characterization of Sleep Quality and Insomnia in Security Guards Working on the Day and Night Shift in Delhi-NCR
Authors: Singhania Manisha , Sheereen Fauzia J. , Ali Taimul , Reza M Kashif , Khan Abdur R. , Alghadir Ahmad H. , Iqbal Amir , Ahmad Fuzail , Beg Rashid A. , Shaphe Mohammad A. 
Published: June 2023

Abstract
Background
In today’s modern world, shift working has become an important part of society and industrial work; prolonged wakefulness is a widespread phenomenon due to which the sleep patterns of individuals are getting disturbed, and many sleep disorders are arising.
Purpose
This study compared the sleep quality and insomnia in the security guards working the day and night shifts.
Methods
The study comprised 100 security guards from Delhi and the NCR region. Self-administered questionnaires, i.e., PSQI and AIS, were used to assess sleep quality and insomnia. Fifty questionnaires were filled out by the day shift security guards, and the night shift security guards filled out 50. Data were analyzed, and a comparison was made using arithmetic mean and standard deviation.
Results
The result showed a significant difference in sleep quality and insomnia in day shift versus night shift working security guards. The average mean value of sleep quality scoring on the day shift was 6.2 ± 2.38; on the night shift, it was 8.62 ± 6.36. The average mean value of the score of insomnia was 4.44 ± 2.22 in day shift security guards and 6.28 ± 3.18 in night shift security guards.
Conclusion
The study concluded that the night shift working security guards had poorer sleep quality, and insomnia was also more prevalent in them than in day shift working security guards.
National strategies for knowledge translation in health policymaking: a scoping review
Authors: Babarczy Balázs , Scarlett Julia , Sharma Tarang , Gaal Peter , Szécsényi-Nagy Balázs , Kuchenmüller Tanja 
Published: June 2023

AbstractBackground and objectives. Without strategic actions in its support, the translation of scientific research evidence into health policy is often absent or delayed. This review systematically maps and assesses national-level strategic documents in the field of knowledge translation (KT) for health policy, and develops a practical template that can support Evidence-informed Policy Network (EVIPNet) Europe countries in producing national strategies for evidence-informed policymaking. Methods. Websites of organisations with strategic responsibilities in KT were electronically searched, based on pre-defined criteria, in July-August 2017, and a search update was carried out in April-June 2021. We included national strategies or elements of national strategies that dealt with KT activities, as well as similar strategies of individual institutions with a national policy focus. Two reviewers screened the strategies for inclusion. Data were analyzed using qualitative content analysis. Results. Sixty-five unique documents were identified, of which 17 were eligible and analysed for their structure and content. Of the 17, one document was a national KT action plan and six documents were institution-level KT strategies. The remaining 10 strategies, which have also been considered, included two national health strategies, five national health research strategies and three national KT strategies (not specific to health). Thirteen structural elements and seven major themes of health policy KT strategies were identified from the studied documents. Conclusion. KT in health policy, as emerged from the national strategies that our mapping identified, is based on the production and accessibility of policy-relevant research, its packaging for policy-making, and the activities related to knowledge exchange. KT strategies may play different roles in the complex and context-specific process of policy making. Our findings show that the main ideas of health-specific EIP literature appear in these strategies, but their effectiveness depends on the way stakeholders use them. Specific knowledge-brokering institutions and organisational capacity, advocacy about the use of evidence, and close collaboration and co-decision making with key stakeholders are essential in furthering the policy uptake of research results.
Mainstream technologies in facilities for people with intellectual disabilities. A mixed-methods study using the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework
Authors: Menschik Christian , Kunze Christophe , Renner Gregor , Etges Theresa 
Published: June 2023

Abstract
People with intellectual disabilities in residential or outpatient facilities for people with disabilities run the risk of being digitally excluded by not having opportunities for taking advantage of the digitalizations’ possibilities. We therefore aim to investigate how disability caregivers and managers describe barriers and facilitating factors to implement and adopt mainstream technology for people with intellectual disabilities in residential or outpatient facilities and how competencies and capabilities of the caregivers are assessed in the procedure. For this reason, we conducted a mixed-methods-study applying the nonadoption, abandonment, scale-up, spread, and sustainability (NASSS) framework. As a result, we identified barriers and facilitators across NASSS domains. 1. Condition: People with intellectual disabilities are a diverse group of people, where the individual condition of the person and e.g. their communication skills were seen as a perquisite for implementing mainstream technologies. 2. Technology: The extent to what mainstream technology fits the individual needs and demands contributed to the implementation process. 3. Value proposition: Communication was seen as a life area where mainstream technology can add value. Adopters: The caregivers needed competencies and capabilities to accompany their caretakers’ technology use. Organization: Missing legal regulations and lack of personnel resources were described as barriers. Wider context: Funding opportunities were seen as unclear in disability services, as mainstream technologies could not be financed as participation benefits. 7. Embedding and adaptation over time: The COVID-19 pandemic has forced facilities to digitalize to some extent, but were still in need of standardized procedures to promote digital participation of their residents.