bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short-term comparison between the effect of two different concentrations of methotrexate on ovarian tissues and function of female albino rats
Authors: Hussein Alak 
Published: January 2023

Back ground: methotrexate is an antifolate that is widely used in cancers and inflammatory or auto- immune diseases, it is also known to be contraindicated in pregnancy, breast feeding and not recommended in patients planning to be parents since it has a harmful effect on fetus and gonads.
Ovarian function can be evaluated by certain parameters like the levels of female hormones or anti- Mullerian hormone which is considered as a good indicator for this purpose or histopathological examination of ovarian follicles especially the primordial follicles.
Objective: the aim of this study is to determine the effect of two different concentrations of methotrexate on ovarian tissue integrity and function.
Materials and method: adult female albino rats (n=30) were randomly divided in to 3 groups; group A (n=10) in which animals were treated with i. p injection of normal saline once weekly for four weeks, group B (n=10) in which animals were treated with i. p. injection of 1mg/ kg bw of methotrexate once weekly for four weeks, and lastly group C in which animals were treated with i. p. injection of 2.5 mg/ kg bw of methotrexate once weekly for four weeks. Then serum level of anti- Mullerian hormone were measured and histopathological examination of the ovaries were done to evaluate ovarian injury caused by methotrexate treatment.
Results: this study has demonstrated that methotrexate in the both 1mg and 2.5 mg / kg of BW doses did not significantly reduce the levels of anti- Mullerian hormone and the number of primordial follicles and atretic follicles were also not significantly affected by the treatment of methotrexate in both doses. While histopathological examination revealed mild ovarian damage in case of treatment with 1mg/ kg bw of methotrexate and moderate damage in case of treatment with 2.5 mg/ kg bw of methotrexate.
Conclusions: there is no important difference between the effects of 1 and 2.5 mg/ kg of BW of methotrexate on ovarian function but there is a slight difference in the effects of the two different doses on the integrity of ovarian tissue.
تأثير عقار داباغليفلوزين على مستوى هيموجلوبين في الدم
Authors: A. Obeed Ahmed , A. AL-Kinani Tahseen , Ibrahim AL- Qadhi Huda 
Published: January 2023

الخلفية: قصور القلب هو متلازمة إكلينيكية معقدة تنتج عن أي مرض قلبي وظيفي أو هيكلي يقلل من قدرة البطين على تعبئة الدم أو ضخه. فقر الدم شائع لدى مرضى قصور القلب ويرتبط بالتدهور من خلال تنشيط المسارات الهرمونية العصبية. عقار داباكليفلوزين هو مثبط انتقائي وقابل للانعكاس للناقل المشترك للصوديوم الجلوكوز 2 (SGLT2). يزيد داباجليفلوزين من مستوى الهيموجلوبين من خلال آليات مختلفة مثل زيادة تركيز البلازما عن طريق إدرار البول أو زيادة تخليق الإريثروبويتين.
الهدف: تقييم تأثير الداباجليفلوزين الإضافي في العلاج التقليدي على الهيموجلوبين في مرضى قصور القلب المصابين بمرض الكلى المزمن (CKD) مع أو بدون داء السكري DM.
المرضى والطرق: كانت هذه دراسة سريرية مستقبلية أجريت في أجنحة طبية في مركز الناصرية للقلب خلال الفترة من 1 نوفمبر / 2021 إلى نهاية يوليو / 2022. تم إجراء البحث على 120 مشاركًا يعانون من قصور في القلب وضعف كلوي. تم تقسيم المرضى إلى مجموعتين. ضمت المجموعة الأولى 60 مريضاً تم إعطاؤهم داباجليفلوزين بالإضافة إلى الأدوية التقليدية ، وتألفت المجموعة الأخرى من 60 مريضاً تلقوا العلاج التقليدي فقط. تمت مطابقة كلا المجموعتين فيما يتعلق بالخصائص الاجتماعية والديموغرافية. تم تسجيل تركيز الهيموجلوبين في اليوم الأول كزيارة أساسية ثم تمت متابعتها بعد أربعة أشهر.
النتائج: قبل العلاج لم تكن هناك فروق ذات دلالة إحصائية في العوامل الاجتماعية والديموغرافية والسريرية بين المجموعتين. في مجموعة داباجليفلوزين ، كان مستوى الهيموجلوبين أعلى بكثير من مستوى ما قبل العلاج (12.53 جم / لتر مقابل 11.85 جم / لتر ، P = 0.016) ، كان لدى المرضى في المجموعة الضابطة مستوى متوسط ​​أقل بكثير من الهيموجلوبين بعد العلاج مقارنة بمستوى خط الأساس ( 11.88 جم / لتر مقابل 12.56 جم / لتر ، P = 0.001).
الاستنتاج: أظهرت الدراسة أن داباجليفلوزين يزيد تركيز الهيموجلوبين ويصحح فقر الدم لدى مرضى قصور القلب المصابين بمرض الكلى المزمن مقارنة بمجموعة التحكم.
MYSIR's Abstracts 2
Authors: Interventional Radiology Malaysian Society of 
Published: January 2023

MYSIR’s Abstracts 2
1. EP01: A RARE CASE OF POST MVA CERVICAL LIGAMENTOUS TEAR COMPLICATED WITH VERTEBRAL ARTERIOVENOUS FISTULA (VAVF) WITH SUCCESSFUL ENDOVASCULAR TREATMENT
2. EP02: SIGNIFICANTLY LESS BLEEDING INTRAOPERATIVELY WITH FAVORABLE POST-SURGICAL OUTCOMES FOLLOWING ENDOVASCULAR COILING AND AMPLATZER VASCULAR PLUG FOR AURICULAR ARTERIO-VENOUS MALFORMATION
3. EP03: POSTERIOR TRANSGLUTEAL CT FLUOROSCOPY GUIDED PERCUTANEOUS DRAINAGE OF DEEP PELVIC ABSCESS IN SULTAN HAJI AHMAD SHAH MEDICAL CENTRE @IIUM (SASMEC @IIUM): A CASE SERIES
4. EP04: PERCUTANEOUS TRANSHEPATIC BILIARY DRAINAGE IN ADULT BILIARY ATRESIA WITH NATIVE LIVER: A CASE SERIES
5. EP05: MAY-THURNER SYNDROME CONUNDRUM: MASSIVE SUBCAPSULAR LIVER HEMATOMA FOLLOWING INTRAVENOUS THROMBOLYSIS FOR DEEP VEIN THROMBOSIS
6. EP06: FIRST SUCCESSFUL TRANSCHOLECYSTO-CYSTIC DUCT COMMON BILE DUCT STENTING IN A CASE OF MALIGNANT OBSTRUCTIVE JAUNDICE
POKOK-POKOK FIKIRAN ASBAB AN-NUZUL DALAM AL-QUR’AN
Authors: Suhilman Suhilman 
Published: January 2023

Al-Qur’an sebagai wahyu Allah yang diturunkan pada Nabi Muhammad SAW. Isinya selalu dikaji dan dibahas secara terus menerus yang tidak pernah habis habisnya sampai hari kiamat,kerana isi kandungannya dapat diaktualkan dalam kondisi apapun,dan juga al-Qur’an diperlihara lansung oleh Allah SWT. Hal ini dinyatakan Allah dalam ayat 9 surat al-Hijr : نوظفاحل هل اناو ركذلا انلزن نحن انا ( رجحلا : 9 ) Artinya: “Sesungguhnya Kami-lah yang menurunkan al-Quran, dan Sesungguhnya Kami benar-benar memeliharanya”. Al-Qur’an dibaca oleh umat Islam baik yang paham artinya maupun yang tidak, bahkan secara khusus pada bulan Ramadhan umat Islam membaca sampai khatam berkali-kali dalam rangka mengikut para Nabi dan para sahabatnya. Al-Qur’an juga setiap tahun juga selalu diperingati waktu turunya pada bulan Ramadhan oleh umat Islam se-Dunia khususnya ummat Islam Indonesia mulai dari tingkat kampung sampai ke kota-kota besar, bahkan sampai ke Istana Negara. Untuk itu penulis ingin membahas masalah Pokok-Pokok Fikiran Asbab An-Nuzul Dalam Al-Qur’an. Mengingat kajian ini sangat luas disamping waktu yang sangat terbatas, maka penulis akan membatasi kajian ini sekitar masalah kata nazalah dan musytaq-nya dalam al-Qur’an pengertian nuzul al-Qur’an, pemakaian kata nazala dan musytaq-nya dalam al-Qur’an perbedaan kata inzal dan tanzil, proses nuzul al-Qur’an, waktu nuzul al-Qur’an, hubungan antara nuzul al-Qur’an dengan lailat al-qadar dan komunikasi Allah dan Rasul.
PENINGKATAN KOMPETENSI GURU DALAM MEMBUAT MEDIA PEMBELAJARAN BERBASIS CANVA MELALUI IN HOUSE TRAINING (IHT) DI SD NEGERI 6 LANJAS TAHUN PELAJARAN 2021/2022
Authors: Dermawanto Dermawanto 
Published: January 2023

Peneliti yang sekaligus kepala sekolah melaksanakan observasi dan wawancara awal terhadap guru guna ingin mengetahui tentang kompetensi guru dalam membuat media pembelajaran berbasis canva. Hasilnya adalah, guru-guru sebenarnya sudah menggunakan alat digital sehari-hari berupa smart phone, akan tetapi guru belum mampu menjadikan alat digital yang sedang trend di masa kini sebagai media dalam proses belajar mengajar. Oleh karenanya disini peneliti hendak meningkatkan kompetensi Guru dalam membuat media pembelajaran berbasis canva melalui In House Training (IHT).
Penelitian ini merupakan penelitian tindakan sekolah, Pada pra siklus peneliti baru mengamati seberapa besar Kompetensi guru dalam membuat media pembelajaran berbasis canva dan hasilnya sangat rendah yakni skor rata-rata 4,1 atau 41,66% dari target skor maksimal 8, artinya Kompetensi GURU dalam membuat media pembelajaran berbasis canva kurang baik, pada siklus I peneliti sudah mengadakan In House Training untuk memperbaiki kompetensi guru dalam membuat media pembelajaran berbasis canva di SD Negeri 6 Lanjas.
Di lihat dari hasil observasi ada peningkatan skor rata-rata dari pra siklus ke siklus I, hasil skor rata-rata observasi pra siklus hanya mencapai skor 4,1 atau 41,66% sementara pada siklus I mencapai 5,5 atau 77,5% dari target skor maksimal yakni 8 yang artinya kompetensi Guru dalam membuat media pembelajaran berbasis canva baik. Hal ini berarti ada kenaikan 35,84% dari skor pra siklus, ada siklus II hasil observasi mencapai skor 7,7 atau 93,33% dari target skor maksimal yakni 8 artinya kompetensi guru dalam membuat media pembelajaran berbasis canva sangat baik. Hal ini berarti ada kenaikan 15,83% dari skor siklus I
Recent developments in isolating methods for exosomes
Authors: Gao Jiahui , Li Ang , Hu Jie , Feng Linxiang , Liu Liu , Shen Zuojun 
Published: January 2023

Exosomes are the smallest extracellular vesicles that can be released by practically all cell types, and range in size from 30 nm to 150 nm. As the major marker of liquid biopsies, exosomes have great potential for disease diagnosis, therapy, and prognosis. However, their inherent heterogeneity, the complexity of biological fluids, and the presence of nanoscale contaminants make the isolation of exosomes a great challenge. Traditional isolation methods of exosomes are cumbersome and challenging with complex and time-consuming operations. In recent years, the emergence of microfluidic chips, nanolithography, electro-deposition, and other technologies has promoted the combination and innovation of the isolation methods. The application of these methods has brought very considerable benefits to the isolation of exosomes such as ultra-fast, portable integration, and low loss. There are significant functional improvements in isolation yield, isolation purity, and clinical applications. In this review, a series of methods for the isolation of exosomes are summarized, with emphasis on the emerging methods, and in-depth comparison and analysis of each method are provided, including their principles, merits, and demerits.
Association of intraoperative hyperglycemia with postoperative composite infection after cardiac surgery with cardiopulmonary bypass: A retrospective cohort study
Authors: Xiong Xinglong , Chen Dongxu , Cai Shuang , Qiu Li , Shi Jing 
Published: January 2023

BackgroundThe association between intraoperative hyperglycemia (IH) and postoperative infections in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) is inadequately studied.MethodsA total of 3,428 patients who underwent cardiac surgery with CPB at our institution between June 1, 2019 and July 30, 2021 were enrolled to evaluate the association of IH (blood glucose ≥ 180 mg/dL) with postoperative infection in patients. The new onset of any type of infection and the optimal cutoff values of intraoperative glucose to predict in-hospital infection were determined.ResultsThe composite outcome occurred in 497 of 3,428 (14.50%) patients. IH was associated with an increased risk of postoperative composite infection [adjusted odds ratio: 1.39, (95% confidence interval), 1.06–1.82, P = 0.016]. Restricted cubic splines were applied to flexibly model and visualize the association of intraoperative peak glucose with infection, and a J-shaped association was revealed. Besides, it was demonstrated that the possibility of infection was relatively flat till 150 mg/dL glucose levels which started to rapidly increase afterward.ConclusionWe summarize that IH is associated with an elevated risk of postoperative new-onset composite infections and perioperative blood glucose management should be more stringent, i.e., lesser than 150 mg/dL in patients undergoing cardiac surgery.
Reservoir characteristics and pore fluid evaluation of Shan 23 Submember transitional shale, eastern Ordos Basin, China: Insights from NMR experiments
Authors: Cai Guangyin , Gu Yifan , Xiong Xianyue , Li Xingtao , Sun Xiongwei , Ni Jia , Jiang Yuqiang , Fu Yonghong , Ou Fang 
Published: January 2023

The Lower Permian Shanxi Formation in the Eastern Ordos Basin is a set of transitional shale, and it is also a key target for shale gas exploration in China. Three sets of organic-rich transitional shale intervals (Lower shale, Middle shale and Upper shale) developed in Shan 23 Submember of Shanxi Formation. Based on TOC test, X-diffraction, porosity, in-situ gas content experiment and NMR experiments with gradient centrifugation and drying temperature, the reservoir characteristics and pore fluid distribution of the three sets of organic-rich transitional shale are studied. The results show that: 1) The Middle and Lower shales have higher TOC content, brittleness index and gas content, reflecting better reservoir quality, while the Upper shales have lower gas content and fracturing ability. The total gas content of shale in the Middle and Lower shales is high, and the lost gas and desorbed gas account for 80% of the total gas content. 2) The Middle shale has the highest movable water content (32.58%), while the Lower shale has the highest capillary bound water content (57.52%). In general, the capillary bound water content of marine-continental transitional shale in the Shan 23 Submember of the study area is high, ranging from 39.96% to 57.52%. 3) Based on pore fluid flow capacity, shale pores are divided into movable pores, bound pores and immovable pores. The Middle shale and the Lower shale have high movable pores, with the porosity ratio up to 27%, and the lower limit of exploitable pore size is 10 nm. The movable pore content of upper shale is 25%, and the lower limit of pore size is 12.6 nm. It is suggested that the Lower and Middle shales have more development potential under the associated development technology.
A comparison between the therapeutic effects of Conbercept combined with panretinal photocoagulation and panretinal photocoagulation monotherapy for high-risk proliferative diabetic retinopathy
Authors: Sun Yaoyao , Qi Huijun 
Published: January 2023

ObjectiveTo compare the therapeutic effects of the administration of intravitreal Conbercept (IVC) plus panretinal photocoagulation (PRP) to that of PRP monotherapy in patients with high-risk proliferative diabetic retinopathy (PDR).MethodsIn this retrospective consecutive case series, we analyzed the data on high-risk PDR patients followed up for 12 months. Patients were divided into two groups: the IVC+PRP group and the PRP monotherapy group. Patients in the IVC+PRP group were initially administered 3 IVC injections and PRP, while patients in the PRP monotherapy group received PRP only. Depending on the grouping criteria, patients in both groups were administered either IVC+PRP or PRP only if the neovascularization (NV) did not regress. From the initiation to month 12 of treatment, we recorded and compared the data on the NV regression rate, improvement in best-corrected visual acuity (BCVA), laser spots, changes in central macular thickness (CMT), complications, and the need for vitrectomy for all patients.ResultsIn this study, 79 eyes of 58 patients in the IVC+PRP group and 86 eyes of 60 patients in the PRP monotherapy group were included. During the follow-up of 12 months, the number of eyes with complete regression, partial regression, and no regression or increase in NV were 56 (70.88%), 23 (29.12%), and 0 (0%) in the IVC+PRP group and 13 (15.12%), 50 (58.14%), and 23 (26.74%) in the PRP group (p &lt; 0.001). The BCVA was significantly higher and CMT was lower in the patients of the IVC+PRP group than in the PRP monotherapy group at 3, 6, and 12 months of follow-up (p &lt; 0.05). The mean number of laser spots was lower in the patients of the IVC+PRP group than in the PRP group (1,453 ± 87 spots vs. 2,267 ± 94 spots, p &lt; 0.05). A significantly lower percentage of patients in the IVC+PRP group underwent vitrectomy than that in the PRP group (7 (8.86%) vs. 27 (31.40%), p &lt; 0.001).ConclusionHigh-risk PDR patients treated with IVC + PRP showed a higher rate of NV regression, more effective improvement in the BCVA, and lower vitrectomy rate compared to those who were administered PRP monotherapy.
Uterine activity modifies the response of the fetal autonomic nervous system at preterm active labor
Authors: Olmos-Ramírez Rocio Lizbeth , Peña-Castillo Miguel Ángel , Mendieta-Zerón Hugo , Reyes-Lagos José Javier 
Published: January 2023

BackgroundThe autonomic nervous system of preterm fetuses has a different level of maturity than term fetuses. Thus, their autonomic response to transient hypoxemia caused by uterine contractions in labor may differ. This study aims to compare the behavior of the fetal autonomic response to uterine contractions between preterm and term active labor using a novel time-frequency analysis of fetal heart rate variability (FHRV).MethodsWe performed a case-control study using fetal R-R and uterine activity time series obtained by abdominal electrical recordings from 18 women in active preterm labor (32−36 weeks of gestation) and 19 in active term labor (39−40 weeks of gestation). We analyzed 20 minutes of the fetal R-R time series by applying a Continuous Wavelet Transform (CWT) to obtain frequency (HF, 0.2−1 Hz; LF, 0.05−0.2 Hz) and time-frequency (Flux0, Flux90, and Flux45) domain features. Time domain FHRV features (SDNN, RMSSD, meanNN) were also calculated. In addition, ultra-short FHRV analysis was performed by segmenting the fetal R-R time series according to episodes of the uterine contraction and quiescent periods.ResultsNo significant differences between preterm and term labor were found for FHRV features when calculated over 20 minutes. However, we found significant differences when segmenting between uterine contraction and quiescent periods. In the preterm group, the LF, Flux0, and Flux45 were higher during the average contraction episode compared with the average quiescent period (p&lt;0.01), while in term fetuses, vagally mediated FHRV features (HF and RMSSD) were higher during the average contraction episode (p&lt;0.05). The meanNN was lower during the strongest contraction in preterm fetuses compared to their consecutive quiescent period (p=0.008).ConclusionThe average autonomic response to contractions in preterm fetuses shows sympathetic predominance, while term fetuses respond through parasympathetic activity. Comparison between groups during the strongest contraction showed a diminished fetal autonomic response in the preterm group. Thus, separating contraction and quiescent periods during labor allows for identifying differences in the autonomic nervous system cardiac regulation between preterm and term fetuses.
Phosphorus addition alleviates the inhibition of nitrogen deposition on photosynthesis of Potentilla tanacetifolia
Authors: Hao Jianhui , Han Hongkun , Liu Ying , Li Jiahuan , Yang Jiyun , Ren Baihui , Bai Long 
Published: January 2023

Atmospheric nitrogen(N) deposition increased soil active N, and excessive N content led to the increase of the ratio of nitrogen to phosphorus (N: P), which changed plant growth from N limitation to phosphorus(P) limitation. Potentilla is not only an important native greening material, but also a common diversity component in various grasslands in China. Its population fluctuation in the process of N deposition will affect the species diversity and productivity of grassland ecosystem. Potting experiment was conducted for 2 years with Potentilla tanacetifolia, a common species in the northern warm steppe, as the material. Through the interactive treatment of different N addition (0, 10, 20, 40 kg N ha yr−1) and P addition (4, 6, 8 kg P ha yr−1) gradients, to analysis the feedback effect between leaf N and P content and net photosynthetic rate (Pn). We explored the N: P threshold of N and P limitation from the perspective of Pn. The results showed that: 1) Under low soil N concentration, P addition can promote N absorption of P.tanacetifolia, while the high soil N concentration can reduce the N: P by increasing the leaf P content to weaken the limiting effect caused by nutrient imbalance of plants. 2) In N addition environment, proper P addition increased Pn by increasing stomatal conductance (Gs), while excessive P addition decreased Gs and inhibited Pn. 3) The Pn showed a single peak normal distribution characteristic with the enhancement of the N: P of leaves, and the Pn was at a high level between 14.5–17.0. It was preliminarily believed that the threshold value of N: P in leaves of P.tanacetifolia was 14.5–17.0. Plant photosynthesis is very sensitive to the environment and easy to be affected by the external environment. The results of N and P addition showed that Pn of broad-leaf forbs was easily affected by N and P restriction, and P addition increased Pn of broad-leaf forbs under N restriction. There was a certain relationship between N:P and Pn. It was preliminarily believed that the N: P of P.tanacetifolia leaves is not limited by nitrogen and phosphorus in the range of 14.5-17.0.
Distinct traces of mixed ancestry in western commercial pig genomes following gene flow from Chinese indigenous breeds
Authors: Peng Yebo , Derks Martijn FL , Groenen Martien AM , Zhao Yiqiang , Bosse Mirte 
Published: January 2023

Studying gene flow between different livestock breeds will benefit the discovery of genes related to production traits and provide insight into human historical breeding. Chinese pigs have played an indispensable role in the breeding of Western commercial pigs. However, the differences in the timing and volume of the contribution of pigs from different Chinese regions to Western pigs are not yet apparent. In this paper, we combine the whole-genome sequencing data of 592 pigs from different studies and illustrate patterns of gene flow from Chinese pigs into Western commercial pigs. We describe introgression patterns from four distinct Chinese indigenous groups into five Western commercial groups. There were considerable differences in the number and length of the putative introgressed segments from Chinese pig groups that contributed to Western commercial pig breeds. The contribution of pigs from different Chinese geographical locations to a given western commercial breed varied more than that from a specific Chinese pig group to different Western commercial breeds, implying admixture within Europe after introgression. Within different Western commercial lines from the same breed, the introgression patterns from a given Chinese pig group seemed highly conserved, suggesting that introgression of Chinese pigs into Western commercial pig breeds mainly occurred at an early stage of breed formation. Finally, based on analyses of introgression signals, allele frequencies, and selection footprints, we identified a ∼2.65 Mb Chinese-derived haplotype under selection in Duroc pigs (CHR14: 95.68–98.33 Mb). Functional and phenotypic studies demonstrate that this PRKG1 haplotype is related to backfat and loin depth in Duroc pigs. Overall, we demonstrate that the introgression history of domestic pigs is complex and that Western commercial pigs contain distinct traces of mixed ancestry, likely derived from various Chinese pig breeds.