bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does cesarean section prevent adverse neonatal outcomes associated with meconium amniotic fluid?
Authors: Ranjbar Amene , Ghamsari Sepideh Rezaei , Taeidi Elham , Mehrnoush Vahid , Darsareh Fatemeh 
Published: September 2023

AbstractBackgroundMaking decisions regarding the mode of delivery in the cases of meconium amniotic fluid (MAF) presents a challenge for healthcare providers. We aimed to compare the neonatal outcome of MAF cases delivered via cesarean section (CS) versus those delivered vaginally to determine if CS is a protective factor against the adverse neonatal outcomes.MethodsIn this retrospective study, we assessed singleton pregnant mothers diagnosed with MAF who gave birth at a tertiary hospital in Bandar Abbas, Iran, between January 2020-2022. Mothers with certain adverse pregnancy conditions were excluded from the study. These conditions included: abnormal fetal heart rate and pattern, bloody amniotic fluid, malpresentation, abnormal placentation, chorioamnionitis, intrauterine growth restriction, intrauterine fetal death, obstructed labor, and maternal comorbidities. The MAF mothers were divided into two groups based on the method of delivery: those who had CS and those who had a normal vaginal delivery (NVD). Demographic factors, obstetrical factors, and neonatal outcomes were compared between the two groups.ResultsOut of 746 MAF mothers, 213 (28.5%) underwent CS, while 533 (71.4%) had NVD. There were no significant differences between the groups in terms of demographic characteristics. Among MAF mothers who had CS, 66.2% were primiparous, and 33.8% were multiparous. For those who had NVD, 35.1% were primiparous, and 64.9% were multiparous. The first and 5-min Apgar values, rates of asphyxia, neonatal intensive care unit (NICU) admission, and neonatal death were not statistically different between the two delivery modes. The rate of newborns who breastfed within the first hour did not differ depending on the mode of delivery. Although initial resuscitation steps were required more frequently in MAF mothers with NVD than in those with CS (11.1% vs. 2.3%), no correlation was found between the mode of delivery and the need for resuscitation using logistic regression.ConclusionsOur research findings suggest that there were no superior neonatal outcomes in terms of CS compared to NVD in MAF mothers. Further studies are needed to provide more substantial evidence to support this conclusion.
Spectral cocycle for substitution tilings
Authors: SOLOMYAK BORIS , TREVIÑO RODRIGO 
Published: September 2023

AbstractThe construction of a spectral cocycle from the case of one-dimensional substitution flows [A. I. Bufetov and B. Solomyak. A spectral cocycle for substitution systems and translation flows. J. Anal. Math.141(1) (2020), 165–205] is extended to the setting of pseudo-self-similar tilings in
${\mathbb R}^d$
, allowing expanding similarities with rotations. The pointwise upper Lyapunov exponent of this cocycle is used to bound the local dimension of spectral measures of deformed tilings. The deformations are considered, following the work of Treviño [Quantitative weak mixing for random substitution tilings. Israel J. Math., to appear], in the simpler, non-random setting. We review some of the results of Treviño in this special case and illustrate them on concrete examples.
The expected nodal volume of non-Gaussian random band-limited functions, and their doubling index
Authors: Sartori Andrea , Wigman Igor 
Published: September 2023

Abstract
The asymptotic law for the expected nodal volume of random non-Gaussian monochromatic band-limited functions is determined in vast generality. Our methods combine microlocal analytic techniques and modern probability theory. A particularly challenging obstacle that we need to overcome is the possible concentration of nodal volume on a small portion of the manifold, requiring solutions in both disciplines and, in particular, the study of the distribution of the doubling index of random band-limited functions. As for the fine aspects of the distribution of the nodal volume, such as its variance, it is expected that the non-Gaussian monochromatic functions behave qualitatively differently compared to their Gaussian counterpart. Some conjectures pertaining to these are put forward within this manuscript.
Derived Category and ACM Bundles of Moduli Space of Vector Bundles on a Curve
Authors: Lee Kyoung-Seog , Moon Han-Bom 
Published: September 2023

Abstract
We show that the derived category of a curve is embedded into the derived category of the moduli space of vector bundles on the curve of coprime rank and degree. We also generalize the semiorthogonal decomposition constructed by Narasimhan and Belmans-Mukhopadhyay. Finally, we produce a one-dimensional family of ACM bundles over the moduli space.
NEW MODULI SPACES OF ONE-DIMENSIONAL SHEAVES ON
Authors: MU DAPENG 
Published: September 2023

AbstractWe define a one-dimensional family of Bridgeland stability conditions on
$\mathbb {P}^n$
, named “Euler” stability condition. We conjecture that the “Euler” stability condition converges to Gieseker stability for coherent sheaves. Here, we focus on
${\mathbb P}^3$
, first identifying Euler stability conditions with double-tilt stability conditions, and then we consider moduli of one-dimensional sheaves, proving some asymptotic results, boundedness for walls, and then explicitly computing walls and wall-crossings for sheaves supported on rational curves of degrees
$3$
and
$4$
.
The effect of slow-release milk replacer feeding on health and behaviour parameters in dairy breed calves
Authors: Krump Lea , Sayers Ríona G. , Sugrue Katie , Kennedy Emer , O'Mahony Jim , Sayers Gearóid P. 
Published: September 2023

AbstractThe aim of this research paper was to evaluate the effect of a slow-release milk replacer on health and behaviour of neonatal dairy calves. This was done with the potential benefits to welfare during transport in mind. A total of 15 calves were randomly divided into three groups of 5, namely, a control group fed twice in 24 h with 3 l of a conventional milk replacer, a slow-release group fed once in 24 h with 2 l of conventional milk replacer and 1 litre of a specialised micro-encapsulated feed and an enriched-replacer group fed once in 24 h with 3 l of milk replacer enriched with micellar casein. Blood samples were taken before feeding and 6, 12, 18 and 24 h after and analysed for acid–base parameters, electrolytes, glucose, haemoglobin, cortisol, insulin, cholecystokinin and adiponectin. Calf behaviour was recorded between 6 and 14 h after feeding. There was a significant increase in blood pH 6 h after feeding in all groups, but the glucose, HCO3− and base excess increased significantly in the slow-release group only, whereas sodium increased significantly in the enriched group only. Glucose levels remained significantly higher in the slow-release group, relative to the control, at 6, 12, and 18 h after feeding. Insulin levels changed significantly over time in the enriched and control group but remained constant in the slow-release group. Insulin levels were significantly higher in the control group when compared to the slow-release group after feeding. Adiponectin changed significantly over time after feeding in the control group only, but no significant changes were observed between the feeding groups. Behavioural patterns were similar in control and slow release groups but less favourable (less lying time, more vocalisations) in the enriched group. In conclusion, once-daily feeding of slow-release milk replacer demonstrated favourable patterns of blood variables related to satiety and hunger as well as behavioural patterns that did not differ from conventional twice-daily feeding.
Description of two new species, Microlaimus paraaffinis sp. nov. and Pseudomicrolaimus major sp. nov. (Nematoda: Microlaimidae), from Yangma Island, the Yellow Sea, China
Authors: Guo Wen , Wang Mengna , Wang Chunming 
Published: September 2023

Abstract
Two new species of Microlaimidae: Microlaimus paraaffinis sp. nov. and Pseudomicrolaimus major sp. nov. are described from Yangma Island, the Yellow Sea. M. paraaffinis sp. nov. is characterized by body length 662–785 μm, six inner and six outer labial sensilla papilliform, four short cephalic setae 3–4 μm in length, amphidial fovea cryptocircular at level of buccal cavity, spicules L-shaped with equal thickness, gubernaculum boat shaped, tail conico-cylindrical with short cylindrical portion. P. major sp. nov. is characterized by large body size, six inner labial sensilla papilliform, six outer labial sensilla and four cephalic sensilla setiform, eight subcephalic setae present, amphidial fovea cryptospiral, anterior pharynx region at the buccal cavity widened, posterior pharynx region with oval-shaped bulb, spicules curved with proximal portion enlarged, gubernaculum boat shaped, tail short and conical. Pictorial key to genus Pseudomicrolaimus is given.
Use of BeSmooth peripheral stent in paediatric cardiology
Authors: Boudjemline Younes 
Published: September 2023

AbstractI read with interest the article by Haddad et al concerning the bench testing of BeSmooth peripheral tests, and I would like to share some thoughts and highlight few points.BeSmooth stent is behaving like any pre-mounted stent available on the market. None can achieve the Holy Grail of being dilatable to adult size without losing their integrity. Until dedicated stents are available, pre-mounted stents are preferred to unmounted stents because of their better profile and deliverability. Technically, proper post-dilatation should be performed in order to avoid and extensive foreshortening and the formation of a ring that would limit further expansion of the stent. BeSmooth stent like other pre-mounted stents can also be used without restriction in situations where overexpansion is not required.BeSmooth stent platform with the knowledge of its intrinsic properties is, in our opinion, a good add-on to the armamentarium of pre-mounted stents used in paediatric cardiology.
Heritage language development and processing: Non-canonical word orders in Mandarin–English child heritage speakers
Authors: Hao Jiuzhou , Chondrogianni Vasiliki , Sturt Patrick 
Published: September 2023

AbstractPrevious research suggests that child HSs’ performance in offline linguistic tasks is typically worse than their age-matched monolingual peers and is modulated by linguistic and child-level factors. This study examined the comprehension and production of three Mandarin non-canonical structures in 5- to 9-year-old Mandarin–English heritage children and Mandarin-speaking monolingual children, including an online processing task. Results showed that heritage children had different performance in production and offline comprehension across structures compared to monolinguals. In online processing, they showed sensitivity to different cues similarly to monolinguals but took longer to revise initial misinterpretations. Within heritage children, we found that presence of morphosyntactic cues facilitated performance across tasks while cross-linguistic influence was only identified in production and offline comprehension but not in online processing. Additionally, input quantity predicted their production and offline comprehension accuracy of non-canonical structures, whereas age modulated their production. Lastly, online processing was not modulated by age nor input.
A new member of the structured light family: optical spatiotemporal vortices
Authors: Feng Fu , Yuan Xiaocong 
Published: September 2023

AbstractThe burgeoning growth of structured light has opened up new possibilities for harnessing the spatiotemporal coupling effects in light. Optical spatiotemporal vortices, as a subset of spatiotemporal light, have emerged as a focal point of recent research, owing to their distinctive characteristics and vast range for application. This unique structured light will endow photons with a new degree of freedom, promising to revolutionize researchers’ understanding of photonics. Conducting thorough research on optical spatiotemporal vortices will establish a solid foundation for the development of innovative physical mechanisms and advanced applications in photonics.
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis
Authors: Yan Pengju , Li Ningning , Ma Ming , Liu Zhaoli , Yang Huicui , Li Jinnan , Wan Chunlei , Gao Shuliu , Li Shuai , Zheng Longtai , Waddington John L. , Xu Lin , Zhen Xuechu 
Published: September 2023

AbstractSubstance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor-1α (HIF-1α) expression by roxadustat (Rox), a drug developed for renal anemia that inhibits HIF prolyl hydroxylase to prevent degradation of HIF-1α, administered either systemically or locally into selected brain regions, suppressed morphine (Mor)-induced conditioned place preference (CPP). A similar effect was observed with methamphetamine (METH). Moreover, Rox also inhibited the expression of both established and reinstated Mor-CPP and promoted the extinction of Mor-CPP. Additionally, the elevation of HIF-1α enhanced hepcidin/ferroportin 1 (FPN1)-mediated iron efflux and resulted in cellular iron deficiency, which led to the functional accumulation of the dopamine transporter (DAT) in plasma membranes due to iron deficiency-impaired ubiquitin degradation. Notably, iron-deficient mice generated via a low iron diet mimicked the effect of Rox on the prevention of Mor- or METH-CPP formation, without affecting other types of memory. These data reveal a novel mechanism for HIF-1α and iron involvement in substance use disorder, which may represent a potential novel therapeutic strategy for the treatment of drug abuse. The findings also repurpose Rox by suggesting a potential new indication for the treatment of substance use disorder.
CRNDE mediated hnRNPA2B1 stability facilitates nuclear export and translation of KRAS in colorectal cancer
Authors: Lu Ya , Zou Renrui , Gu Quan , Wang Xinyue , Zhang Junying , Ma Rong , Wang Ting , Wu Jianzhong , Feng Jifeng , Zhang Yuan 
Published: September 2023

AbstractDevelopment of colorectal cancer (CRC) involves activation of Kirsten rat sarcoma viral oncogene homolog (KRAS) signaling. However, the post-transcriptional regulation of KRAS has yet to be fully characterized. Here, we found that the colorectal neoplasia differentially expressed (CRNDE)/heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) axis was notably elevated in CRC and was strongly associated with poor prognosis of patients, while also significantly promoting CRC cell proliferation and metastasis both in vitro and in vivo. Furthermore, CRNDE maintained the stability of hnRNPA2B1 protein by inhibiting E3 ubiquitin ligase TRIM21 mediated K63 ubiquitination-dependent protein degradation. CRNDE/hnRNPA2B1 axis facilitated the nuclear export and translation of KRAS mRNA, which specifically activated the MAPK signaling pathway, eventually accelerating the malignant progression of CRC. Our findings provided insight into the regulatory network for stable hnRNPA2B1 protein expression, and the molecular mechanisms by which the CRNDE/hnRNPA2B1 axis mediated KRAS nucleocytoplasmic transport and translation, deeply underscoring the bright future of hnRNPA2B1 as a promising biomarker and therapeutic target for CRC.
A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets
Authors: Kulcsár Péter István , Tálas András , Ligeti Zoltán , Tóth Eszter , Rakvács Zsófia , Bartos Zsuzsa , Krausz Sarah Laura , Welker Ágnes , Végi Vanessza Laura , Huszár Krisztina , Welker Ervin 
Published: September 2023

AbstractStreptococcus pyogenes Cas9 (SpCas9) has been employed as a genome engineering tool with a promising potential within therapeutics. However, its off-target effects present major safety concerns for applications requiring high specificity. Approaches developed to date to mitigate this effect, including any of the increased-fidelity (i.e., high-fidelity) SpCas9 variants, only provide efficient editing on a relatively small fraction of targets without detectable off-targets. Upon addressing this problem, we reveal a rather unexpected cleavability ranking of target sequences, and a cleavage rule that governs the on-target and off-target cleavage of increased-fidelity SpCas9 variants but not that of SpCas9-NG or xCas9. According to this rule, for each target, an optimal variant with matching fidelity must be identified for efficient cleavage without detectable off-target effects. Based on this insight, we develop here an extended set of variants, the CRISPRecise set, with increased fidelity spanning across a wide range, with differences in fidelity small enough to comprise an optimal variant for each target, regardless of its cleavability ranking. We demonstrate efficient editing with maximum specificity even on those targets that have not been possible in previous studies.
Broad fault zones enable deep fluid transport and limit earthquake magnitudes
Authors: Leptokaropoulos Konstantinos , Rychert Catherine A. , Harmon Nicholas , Schlaphorst David , Grevemeyer Ingo , Kendall John-Michael , Singh Satish C. 
Published: September 2023

AbstractConstraining the controlling factors of fault rupture is fundamentally important. Fluids influence earthquake locations and magnitudes, although the exact pathways through the lithosphere are not well-known. Ocean transform faults are ideal for studying faults and fluid pathways given their relative simplicity. We analyse seismicity recorded by the Passive Imaging of the Lithosphere-Asthenosphere Boundary (PI-LAB) experiment, centred around the Chain Fracture Zone. We find earthquakes beneath morphological transpressional features occur deeper than the brittle-ductile transition predicted by simple thermal models, but elsewhere occur shallower. These features are characterised by multiple parallel fault segments and step overs, higher proportions of smaller events, gaps in large historical earthquakes, and seismic velocity structures consistent with hydrothermal alteration. Therefore, broader fault damage zones preferentially facilitate fluid transport. This cools the mantle and reduces the potential for large earthquakes at localized barriers that divide the transform into shorter asperity regions, limiting earthquake magnitudes on the transform.
Control of arbuscule development by a transcriptional negative feedback loop in Medicago
Authors: Zhang Qiang , Wang Shuangshuang , Xie Qiujin , Xia Yuanjun , Lu Lei , Wang Mingxing , Wang Gang , Long Siyu , Cai Yunfei , Xu Ling , Wang Ertao , Jiang Yina 
Published: September 2023

AbstractMost terrestrial plants establish a symbiosis with arbuscular mycorrhizal fungi (AMF), which provide them with lipids and sugars in exchange for phosphorus and nitrogen. Nutrient exchange must be dynamically controlled to maintain a mutually beneficial relationship between the two symbiotic partners. The WRI5a and its homologues play a conserved role in lipid supply to AMF. Here, we demonstrate that the AP2/ERF transcription factor MtERM1 binds directly to AW-box and AW-box-like cis-elements in the promoters of MtSTR2 and MtSTR, which are required for host lipid efflux and arbuscule development. The EAR domain-containing transcription factor MtERF12 is also directly activated by MtERM1/MtWRI5a to negatively regulate arbuscule development, and the TOPLESS co-repressor is further recruited by MtERF12 through EAR motif to oppose MtERM1/MtWRI5a function, thereby suppressing arbuscule development. We therefore reveal an ERM1/WRI5a–ERF12–TOPLESS negative feedback loop that enables plants to flexibly control nutrient exchange and ensure a mutually beneficial symbiosis.
Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA
Authors: Malnar Črnigoj Mirjana , Čerček Urša , Yin Xiaoke , Ho Manh Tin , Repic Lampret Barbka , Neumann Manuela , Hermann Andreas , Rouleau Guy , Suter Beat , Mayr Manuel , Rogelj Boris 
Published: September 2023

AbstractThe expanded hexanucleotide GGGGCC repeat mutation in the C9orf72 gene is the main genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Under one disease mechanism, sense and antisense transcripts of the repeat are predicted to bind various RNA-binding proteins, compromise their function and cause cytotoxicity. Here we identify phenylalanine-tRNA synthetase (FARS) subunit alpha (FARSA) as the main interactor of the CCCCGG antisense repeat RNA in cytosol. The aminoacylation of tRNAPhe by FARS is inhibited by antisense RNA, leading to decreased levels of charged tRNAPhe. Remarkably, this is associated with global reduction of phenylalanine incorporation in the proteome and decrease in expression of phenylalanine-rich proteins in cellular models and patient tissues. In conclusion, this study reveals functional inhibition of FARSA in the presence of antisense RNA repeats. Compromised aminoacylation of tRNA could lead to impairments in protein synthesis and further contribute to C9orf72 mutation-associated pathology.
Bridging of host-microbiota tryptophan partitioning by the serotonin pathway in fungal pneumonia
Authors: Renga Giorgia , D’Onofrio Fiorella , Pariano Marilena , Galarini Roberta , Barola Carolina , Stincardini Claudia , Bellet Marina M. , Ellemunter Helmut , Lass-Flörl Cornelia , Costantini Claudio , Napolioni Valerio , Ehrlich Allison K. , Antognelli Cinzia , Fini Massimo , Garaci Enrico , Nunzi Emilia , Romani Luigina 
Published: September 2023

AbstractThe aromatic amino acid L-tryptophan (Trp) is essentially metabolized along the host and microbial pathways. While much is known about the role played by downstream metabolites of each pathways in intestinal homeostasis, their role in lung immune homeostasis is underappreciated. Here we have examined the role played by the Trp hydroxylase/5-hydroxytryptamine (5-HT) pathway in calibrating host and microbial Trp metabolism during Aspergillus fumigatus pneumonia. We found that 5-HT produced by mast cells essentially contributed to pathogen clearance and immune homeostasis in infection by promoting the host protective indoleamine-2,3-dioxygenase 1/kynurenine pathway and limiting the microbial activation of the indole/aryl hydrocarbon receptor pathway. This occurred via regulation of lung and intestinal microbiota and signaling pathways. 5-HT was deficient in the sputa of patients with Cystic fibrosis, while 5-HT supplementation restored the dysregulated Trp partitioning in murine disease. These findings suggest that 5-HT, by bridging host-microbiota Trp partitioning, may have clinical effects beyond its mood regulatory function in respiratory pathologies with an inflammatory component.