bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study of TOPSIS‐based GCMs selection and multi‐model ensemble
Authors: Han Rucun , Li Zhanling , Han Yuanyuan , Huo Pengying , Li Zhanjie 
Published: July 2023

AbstractGeneral circulation models (GCMs) are developed to simulate the past climate and generate future climate predictions. In the context of global warming, their important roles in identifying possible solutions to water resources planning/management are recognized by the world. However, in actual and regional implementation, due to many factors like initial and boundary conditions, parameters and model structures and so forth, there are great variabilities and uncertainties across the future climate projections of GCMs outputs, which has attracted criticism from water resources planners. Thus, the GCMs usually must be evaluated for assessing their performances in simulating the historical observations. Currently, there are many different conclusions and opinions as to whether the optimal individual model is more advantageous or whether the combined consideration of MME works better. The purpose of this paper is to compare the advantages and disadvantages between the selection of the optimal single GCM and multi‐model ensemble (MME) based on one of the more objective selection methods called TOPSIS. The results show that the performances of GCMs in simulating precipitation and temperature in different climate subregions over China are not identical. For CMIP6 GCMs simulations, the optimal precipitation GCM is CMCC‐CM2‐SR5 for EC, MIROC6 for SC, SWC and NWC, CESM2‐WACCM for NC and NEC, and FGOALS‐g3 for QTP. As for temperature, only NESM3 and BCC‐ESM1 are the optimal GCM for QTP and NWC, respectively; in other subregions, MME is better than single GCM. In general, a simple arithmetic averaging approach employed to generate the MME model is not superior to the optimal GCM, although the error metric with the observed data is reduced, at the cost of a severe compression of the interannual variability.
Evaluation of the role of mitofusin‐1 and mitofusin‐2 in periodontal disease
Authors: Kırmızıgül Ömer Alperen , Sabanci Arife , Dişli Faruk , Yıldız Sedat , Milward Michael R. , Aral Kübra 
Published: July 2023

AbstractBackgroundMitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria‐endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation. Previously, proteins that have been associated with these MERC contact sites mitofusin‐1 (MFN1) and mitofusin‐2 (MFN2) have been found to be downregulated in periodontal disease in vitro. Therefore, the aim of the current study was to evaluate MFN1 and MFN2 in gingival crevicular fluid (GCF) of patients with periodontal disease compared with healthy controls clinically.MethodsA total of 48 participants were divided into three groups including periodontally healthy (n = 16), patients with gingivitis (n = 16), and patients with stage 3 grade B periodontitis (n = 16). GCF levels of MFN1, MFN2, calcium (Ca), caspase‐1, and tumor necrosis factor‐alpha (TNF‐α) were determined via enzyme‐linked immunosorbent assay (ELISA). Results were calculated as total amount and concentration.ResultsMFN1 levels (total amount) were significantly higher in patients with periodontitis and gingivitis when compared with healthy controls (p < 0.05). However, concentration levels of MFN1, MFN2, Ca, caspase‐1, TNF‐α significantly decreased in periodontal disease groups compared with healthy controls (p < 0.05). A positive correlation was detected among all evaluated markers (p < 0.05).ConclusionThe MERC protein MFN1 may have a role in the pathogenesis of periodontal disease due to its increase in GCF of patients with periodontitis and gingivitis.
Periodontal ligament‐associated protein‐1 promotes osteoclastogenesis in mice by modulating TGF‐β1/Smad1 pathway
Authors: Liu Shuang , Yu Xijiao , Guo Qiushuang , Zhao Shuaiqi , Yan Kaixian , Hou Meng , Bai Fuxiang , Li Shu 
Published: July 2023

AbstractBackgroundPeriodontal ligament‐associated protein‐1 (PLAP‐1), an important target molecule of osteoarthritis research, may affect alveolar bone resorption. The aim of our study was to comprehensively and systematically detect the effect of PLAP‐1 on alveolar bone resorption and the underlying mechanism in PLAP‐1 knockout mouse models.MethodsWe used a PLAP‐1 knockout (C57BL/6N‐Plap‐1−/−) mouse model to investigate the effect of PLAP‐1 on osteoclast differentiation and the underlying mechanism by adding Porphyromonas gingivalis lipopolysaccharide to stimulate bone marrow‐derived macrophages. The effect of PLAP‐1 on alveolar bone resorption and the underlying mechanism were studied using a ligature periodontitis model, with microcomputed tomography imaging, immunochemistry, and immunofluorescence.ResultsThe in vitro analysis results demonstrated that PLAP‐1 knockout significantly inhibited osteoclast differentiation under both normal and inflammatory conditions. Bioinformatic analysis, immunofluorescence, and co‐immunoprecipitation showed colocalization and interaction between PLAP‐1 and transforming growth factor beta 1 (TGF‐β1). The phosphorylation of Smad1 was reduced in the PLAP‐1 knockout cells compared with that in the cells from wild‐type mice. The in vivo analysis results demonstrated that PLAP‐1 knockout decreased bone resorption and the levels of osteoclast differentiation markers in experimental periodontitis compared with those in wild‐type mice. Immunofluorescence staining confirmed colocalization of PLAP‐1 and TGF‐β1 in the experimental periodontitis model. The phosphorylation level of Smad1 was significantly reduced in PLAP‐1 knockout mice compared with that in wild‐type mice.ConclusionsThis study revealed that the knockout of PLAP‐1 inhibits osteoclast differentiation and decreases alveolar bone resorption through the TGF‐β1/Smad1 signaling pathway, which could serve as an innovative target for the prevention and treatment of periodontitis.
Early Changes in Porcine Larynges Following Injection of Motor‐Endplate Expressing Muscle Cells for the Treatment of Unilateral Vocal Fold Paralysis
Authors: Kaefer Samuel L. , Zhang Lujuan , Morrison Rachel A. , Brookes Sarah , Awonusi Oluwaseyi , Shay Elizabeth , Hoilett Orlando S. , Anderson Jennifer L. , Goergen Craig J. , Voytik‐Harbin Sherry , Halum Stacey 
Published: July 2023

ObjectivesNo curative injectable therapy exists for unilateral vocal fold paralysis. Herein, we explore the early implications of muscle‐derived motor‐endplate expressing cells (MEEs) for injectable vocal fold medialization after recurrent laryngeal nerve (RLN) injury.MethodsYucatan minipigs underwent right RLN transection (without repair) and muscle biopsies. Autologous muscle progenitor cells were isolated, cultured, differentiated, and induced to form MEEs. Three weeks after the injury, MEEs or saline were injected into the paralyzed right vocal fold. Outcomes including evoked laryngeal electromyography (LEMG), laryngeal adductor pressure, and acoustic vocalization data were analyzed up to 7 weeks post‐injury. Harvested porcine larynges were examined for volume, gene expression, and histology.ResultsMEE injections were tolerated well, with all pigs demonstrating continued weight gain. Blinded analysis of videolaryngoscopy post‐injection revealed infraglottic fullness, and no inflammatory changes. Four weeks after injection, LEMG revealed on average higher right distal RLN activity retention in MEE pigs. MEE‐injected pigs on average had vocalization durations, frequencies, and intensities higher than saline pigs. Post‐mortem, the MEE‐injected larynges revealed statistically greater volume on quantitative 3D ultrasound, and statistically increased expression of neurotrophic factors (BDNF, NGF, NTF3, NTF4, NTN1) on quantitative PCR.ConclusionsMinimally invasive MEE injection appears to establish an early molecular and microenvironmental framework to encourage innate RLN regeneration. Longer follow‐up is needed to determine if early findings will translate into functional contraction.Level of EvidenceNA Laryngoscope, 134:272–282, 2024
Visually enhanced vestibulo‐ocular reflex gain in patients with vestibular disease
Authors: Kim Eric K. , Sienko Natalie , Gardi Adam , Krauter Roseanne , Pasquesi Lauren , Sharon Jeffrey D. 
Published: July 2023

AbstractObjectiveVestibular migraine (VM) is a diagnostic challenge. Visually enhanced vestibulo‐ocular reflex (VVOR) gain, a measure of the visual–vestibular interaction, has been proposed as a tool for diagnosing VM. This study seeks to evaluate VVOR gain's diagnostic capability to predict VM and to compare the phenotypes of vestibular patients with elevated versus normal/low VVOR gain.MethodsA retrospective review of consecutive adult patients at a dizziness clinic from October 2016 and December 2020 was conducted. VVOR gain's diagnostic performance was assessed with the area under the receiver operating characteristic (AUROC) analysis. Demographic factors and clinical presentations were compared between vestibular patients with elevated versus normal/low VVOR gain.ResultsOne hundred forty patients (70 with VM) were analyzed. VVOR gain was elevated in 68.6% of patients with VM, compared to 52.9% of patients without VM (p = .057). The AUROC of VVOR gain was 0.5902 (95% confidence interval: 0.4958–0.6846). Vestibular patients with elevated VVOR gain were younger than those with normal/low VVOR gain (mean age 50 vs. 62, p < .0001). A higher proportion of subjects with elevated VVOR gain had symptoms triggered by certain foods (17.6% vs. 5.5%, p = .040) and experienced sound sensitivity (34.1% vs. 18.2%, p = .040) and motion sensitivity (23.5% vs. 9.1%, p = .041). A greater proportion of VM patients with elevated VVOR gain were triggered by certain foods (27.1% vs. 0%, p = .006).ConclusionVVOR gain alone has limited ability to discriminate VM from other vestibular conditions and must be interpreted carefully. VVOR gain elevation may be associated with food triggers and motion and sound sensitivity.Level of EvidenceIV.
First evaluation of an ovine training model for sialendoscopy
Authors: Borner Urs , Caversaccio Marco , Wagner Franca , Marchal Francis , Anschuetz Lukas 
Published: July 2023

AbstractObjectiveSialendoscopy is a minimally invasive diagnostic and therapeutic technique used in the treatment of various salivary gland diseases. To date, there are very few suitable training models other than the pig's head, which has been used at the European Sialendoscopy Training Center for 22 years. The goal of this study was to describe an ovine model for sialendoscopy training and compare the ovine model's to the human anatomy. We propose a step‐by‐step approach for sialendoscopy training using this ex‐vivo model.MethodsThe anatomy of the ovine salivary ducts and glands was assessed by magnetic resonance imaging using one fresh ovine head. Thereafter, the model was designed during dissection by an experienced sialendoscopist. The various steps were then validated during consecutive dissections using a Likert‐scale questionnaire.ResultsThe full model was described in the form of a dissection guide and allowed reliable diagnostic sialendoscopy in 10/10 Stenson's and in 5/10 Wharton's ducts. Moreover, interventional sialendoscopy was simulated to provide a training model for the removal of sialoliths in the Stenson's duct. The human and ovine anatomy are quite similar allowing a training experience close to reality.ConclusionWe developed and evaluated an ovine model with the goal of improving training in diagnostic and interventional sialendoscopy. In particular, the Stenson's duct can be successfully prepared, probed and subjected to sialendoscopy. The realistic anatomical environment and excellent tissue quality created a life‐like training experience for an experienced sialendoscopist. Further studies with beginners are necessary to validate this model as a training model.Level of Evidence4.
Discretization of inverse scattering on a half line
Authors: Korotyaev Evgeny L. 
Published: July 2023

AbstractWe solve inverse scattering problem for Schrödinger operators with compactly supported potentials on the half line. We discretize S‐matrix: We take the value of the S‐matrix on some infinite sequence of positive real numbers. Using this sequence obtained from S‐matrix, we recover uniquely the potential by a new explicit formula, without the Gelfand–Levitan–Marchenko equation.
Analyticity and stability results for a plate‐membrane type transmission problem
Authors: Barraza Martínez Bienvenido , González Ospino Jonathan , Hernández Monzón Jairo 
Published: July 2023

AbstractIn this paper, we consider a transmission problem for a system of a thermoelastic plate with (or without) a rotational inertia coupled with a membrane. On the plate a structural damping may or may not act, and on the membrane a damping of Kelvin–Voigt type may or may not be present; free boundary operators for the plate are considered in the coupling with the membrane. We prove well‐posedness of the problem and higher regularity of the solution. Depending on the damping and on the presence of the rotational term, we establish strong stability, exponential stability, lack of exponential stability, polynomial stability, and analyticity of the semigroup associated to the transmission problem.
Metabolomics Analysis Reveals the Potential Relationship Between Sow Colostrum and Neonatal Serum Metabolites in Different Pig Breeds
Authors: Cheng Yating , Azad Md. Abul Kalam , Ding Sujuan , Liu Yating , Blachier François , Ye Ting , Kong Xiangfeng 
Published: July 2023

ScopeColostrum composition is an important indicator of newborn piglet survival and growth. However, limited information is available on the association between colostrum metabolites in sows and serum metabolites in neonates. Therefore, the present study aims to determine the metabolites in the colostrum of sows, in the serum of their offspring piglets, and mother‐offspring metabolite correlations in different pig breeds.Methods and resultsColostrum and serum samples are collected from 30 sows and their piglets from three pig breeds (Taoyuan black, TB; Xiangcun black, XB; and Duroc) to analyze the targeted metabolomics. This study identifies 191 metabolites in the colostrum of sows, including fatty acids, amino acids, bile acids, carnitines, carbohydrates, and organic acids, and the concentrations of these metabolites are highest in the TB pigs. Metabolite profiles in sow colostrum and piglet serum differ among Duroc, TB, and XB pigs, and the matching metabolites are mainly enriched in the digestive system and transportation pathways. Furthermore, identification of the associations between metabolites in the colostrum of sows and their neonate sera suggests that metabolite compounds from colostrum are transported to suckling piglets.ConclusionThe present study findings deepen the understanding of the composition of sow colostrum metabolites and the transportation of metabolites from sow colostrum to piglets. The findings also provide insight regarding the development of dietary formulas that resemble the sow colostrum for newborn animals to maintain health and improve the early growth of offspring.
Dietary Apigenin Relieves Body Weight and Glycolipid Metabolic Disturbance via Pro‐Browning of White Adipose Mediated by Autophagy Inhibition
Authors: Xiong Shaofeng , Yu Shumin , Wang Kun , Xiong Xiaowei , Xia Min , Zeng Guohua , Huang Qiren 
Published: July 2023

ScopeApigenin (AP) has many pharmacological activities, including anti‐inflammation, hyperlipidemia‐lowering, and so on. Previous studies show that AP can reduce lipid accumulation in adipocytes in vitro. However, it remains unclear whether and how AP can promote fat‐browning. Therefore, mouse obesity model and preadipocyte induction model in vitro are used to investigate the effects of AP on glycolipid metabolism, browning and autophagy as well as the possible mechanisms.Methods and resultsThe obese mice are intragastrically administrated with AP (0.1 mg g−1 d−1) for 4 weeks; meanwhile, the differentiating preadipocytes are respectively treated with the indicated concentrations of AP for 48 h. Metabolic phenotype, lipid accumulation, and fat‐browning are respectively evaluated by morphological, functional, and specific markers analysis. The results show that AP treatment alleviates the body weight, glycolipid metabolic disorder, and insulin resistance in the obese mice , which is contributed to the pro‐browning effects of AP in vivo and in vitro. Moreover, the study finds that the pro‐browning effect of AP is accomplished through autophagy inhibition mediated by the activation of PI3K‐Akt‐mTOR pathway.ConclusionsThe findings highlight that autophagy inhibition promotes the browning of white adipocytes and suggest that AP would prevent and treat obesity and the associated metabolic disorders.
Ethanol Extract of Citrus grandis ‘Tomentosa’ Exerts Anticancer Effects by Targeting Skp2/p27 Pathway in Non‐Small Cell Lung Cancer
Authors: Huang Da , Wu Pei‐En , Chen Zi‐Jie , Pang Yan‐Chun , Xu Zi‐Wei , Tan Jingbo , Jiang Zhi‐Hua , Yang Bing‐Bing , Zhan Ruoting , Xu Hui , Liu Yong‐Qiang 
Published: July 2023

ScopeThis study aims to investigate the anticancer properties of Citrus grandis ‘Tomentosa’ (CGT) in non‐small cell lung cancer (NSCLC).Methods and resultsThe ethanol extract of CGT (CGTE) is prepared by using anhydrous ethanol and analyzed by ultra‐performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS), revealing that the main chemical components in CGTE are flavonoids and coumarins, such as naringin, rhoifolin, apigenin, bergaptol, and osthole. CGTE at concentrations without inducing cell death significantly inhibits cell proliferation via inducing cell cycle G1 phase arrest by MTT, colony formation, and flow cytometry assays, implying that CGT has anticancer potential. CGTE markedly inhibits the activity of Skp2‐SCF E3 ubiquitin ligase, decreases the protein level of Skp2, and promotes the accumulation of p27 by co‐immunoprecipitation (co‐IP) and in vivo ubiquitination assay; whereas Skp2 overexpression rescues the effects of CGTE in NSCLC cells. In subcutaneous LLC allograft and A549 xenograft mouse models, CGTE, without causing obvious side effects in mice, significantly inhibits lung tumor growth by targeting the Skp2/p27 signaling pathway.ConclusionThese findings demonstrate that CGTE efficiently inhibits NSCLC proliferation both in vitro and in vivo by targeting the Skp2/p27 signaling pathway, suggesting that CGTE may serve as a therapeutic candidate for NSCLC treatment.
Optimized MSA DPD method for improving 5G multiband optical fronthaul performance
Authors: Hadi Muhammad Usman , Murtaza Ghulam , Kausar Shafaq 
Published: July 2023

AbstractA modified optimized magnitude‐selective affine (OMSA) model‐based digital predistortion (DPD) is presented that introduces the weighting function into our earlier proposed magnitude‐selective affine (MSA) method with an aim to further reduce the complexity overheads without affecting performance compared to the MSA method. This model utilizes a power‐reliant weighted function rather than the summation of MSA quantities for improving the multiband 5G new radio (NR) analog radio over fiber system performance. The OMSA‐DPD method is tested using 5G NR signals which are transmitted over a 10‐km fiber length. The performance of the OMSA‐DPD method is assessed in comparison to MSA and generalized memory polynomial (GMP) methods in terms of adjacent channel power ratio, error vector magnitude, and complexity. The experimental results show that the OMSA‐DPD method achieves better performance with lower complexity compared to the MSA and GMP models, meeting the 3GPP limits.
Spoof surface plasmon polaritons of complementary periodic units with negative group velocity effect
Authors: Meng Jie , Li Weiwen , Zhang Liangcai 
Published: July 2023

AbstractPeriodically patterned conductor surfaces can transmit electromagnetic modes similar to surface plasmon polaritons, which are called spoof surface plasmon polaritons (SSPPs). In this paper, noncoplanar dentate complementary structure units are proposed. In this case, the fundamental SSPP is split into two modes, of which the mode in the high‐frequency side exhibits negative group velocity (NGV) near the cutoff frequency. The dispersion characteristics of NGV modes can be controlled by manipulating the symmetry of the complementary structure. It is confirmed that the actual transmission wave in the SSPP waveguide is the superposition result of the two split‐mode wave components.
Evaluation of Wait Times for Otolaryngology Appointments in Illinois
Authors: Patel Evan A. , Poulson Trevor A. , Shah Manushi , Jagasia Ashok A. 
Published: July 2023

AbstractObjectiveThe objective of this study was to quantify the wait times that patients may encounter for common clinical diagnoses when seeking otolaryngology care, while determining whether a wait time disparity exists based on geographic location within Illinois.MethodsIn November 2022, a list of Illinois otolaryngologists was obtained from www.entnet.org. Using a uniform script, each of the 291 otolaryngologists were contacted. The caller posed as a new patient with either sudden sensorineural hearing loss, a neck mass, or chronic sinusitis. Each clinic was called 3 times and wait times were recorded. One hundred fifty‐eight otolaryngologists were included in the analysis.ResultsThe average statewide wait time for a new patient presenting with sudden unilateral hearing loss, a neck mass, and chronic sinusitis was 18.0, 22.6, and 25.5 days, respectively. There was no statistically significant difference between urban and rural wait times.DiscussionAlthough wait time differences were noted, the lack of urban versus rural p value significance may be attributed to the small sample size (n = 11) of rural otolaryngologists in Illinois. However, the overall wait times in this study were longer compared to those reported in other studies, suggesting that the current number of otolaryngologists in Illinois is inadequate to meet the public need.Implications for PracticeWe have demonstrated that the current demand for otolaryngology care is outstripping the existing supply in Illinois. This suggests that an emphasis should be placed on training more otolaryngologists, or increasing the use of physician extenders, while incentivizing otolaryngologists to practice in rural areas.Level of Evidence5