bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atopic dermatitis and risk of 14 site-specific cancers: a Mendelian randomization study
Authors: Liu Qiang , Chen Li , Wang Yipeng , Wang Xiangyu , Lewis Sarah J , Wang Jing 
Published: March 2023

IMPORTANCEAtopic dermatitis (AD) accounts for a large proportion of the burden of skin disease with a prevalence of around 10% among adults worldwide. In addition, systematic reviews and meta-analyses have found that AD is associated with cancer risk at several sites, if found to be causal this could highlight potential treatment targets to reduce cancer risk.OBJECTIVETo assess the potential causative link between AD and 14 site-specific cancers in a two-sample Mendelian randomization study.EXPOSUREAtopic dermatitisDESIGN, SETTING, AND PARTICIPANTSFrom the largest genome-wide association study (GWAS) of AD (10,788 cases and 30,047 non-cases), genetic variants highly associated (P < 5E-08) with AD in European population were selected as instrumental variables (IVs). Data from large cancer consortia, as well as the UK Biobank study(n=442,239) and the FinnGen study (n=218,792) were employed to assess genetic associations with 14 site-specific cancers and overall cancer. A set of complementary approaches and sensitivity analyses were carried out to examine the robustness of our results. In addition, associations for the same cancer site from different data sources were combined using meta-analyses.RESULTSWe discovered no strong causal evidence of AD on the risk of overall cancer, with effect estimates close to zero. After Benjamini–Hochberg correction, the inverse weighted method indicated no association of AD on overall cancer risk in both the UK biobank (OR, 1.00; 95%CI, 0.94-1.06; FDR, 0.98) and FinnGen studies (OR, 0.96; 95%CI, 0.92, 1.02; FDR, 0.68). No strong evidence of association was found between genetically predicted AD and the risk of any other site-specific cancers.CONCLUSIONS AND RELEVANCEOur MR investigation does not support a causal effect of AD on cancer risk. This finding has important implications for the prevention and management of both AD and cancer, as it reduces the concern of potential adverse effects of AD on cancer outcomes.
Broad and potent neutralizing mAbs are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection
Authors: Seow Jeffrey , Shalim Zayed A. , Graham Carl , Kimuda Simon , Pillai Aswin , Lechmere Thomas , Kurshan Ashwini , Khimji Atika M. , Snell Luke B. , Nebbia Gaia , Mant Christine , Waters Anele , Fox Julie , Malim Michael H. , Doores Katie J. 
Published: March 2023

AbstractDespite the success of COVID-19 vaccines in preventing infection and/or severe disease, with the emergence of SARS-CoV-2 variants of concern (VOC) which encode mutations in Spike, and the waning of vaccine induced immunity, there has been an increase in SARS-CoV-2 infections in vaccinated individuals which leads to increased serum neutralization breadth. However, how exposure to a heterologous Spike broadens the neutralizing response at the monoclonal antibody (mAb) level is not fully understood. Through isolation of 119 mAbs from three individuals receiving two-doses of BNT162b2 vaccine before becoming delta or omicron/BA.1-infected, we show that breadth arises from re-activation and maturation of B cells generated through previous COVID-19 vaccination rather than ade novoresponse specific to the VOC Spike. Isolated mAbs frequently show reduced neutralization of current circulating variants including BA.2.75.2, XBB, XBB.1.5 and BQ.1.1 confirming continuous selective pressure on Spike to evolve and evade neutralization. However, isolation of mAbs that display effective cross-neutralization against all variants indicate the presence of conserved epitopes on RBD and a lesser extent NTD. These findings have implications for selection of Spike antigens for next-generation COVID-19 vaccines.
Do customer centricity and innovativeness mediate the relationship between total quality management and the corporate success of SaaS companies?
Authors: Dash Ajitabh 
Published: March 2023

PurposeThis research explores the mediating role of a firm's innovativeness and customer orientation on the relationship between commercial success and total quality management (TQM) in the Indian SaaS (Software-as-a-Service) sector.Design/methodology/approachThe hypotheses suggested for this study were validated using partial least squares-based structural equation modeling on data collected from 189 executives working in SaaS companies in India.FindingsThe findings of this study revealed that a SaaS company's innovativeness fully mediates the relationship between TQM and corporate performance, whereas the customer orientation of SaaS companies partially mediates the relationship between TQM and corporate performance.Originality/valueFindings of this paper indicate that, in addition to TQM deployment, SaaS companies' innovativeness and customer-focused strategy will improve their corporate performance. With minimal research focusing on India, this study may be considered a pioneer work. It can serve as a basis for SaaS company promoters to improve their corporate performance by implementing TQM processes.
Organization capital and firm risks
Authors: Hasan Mostafa Monzur , Cheung Adrian (Wai Kong) 
Published: March 2023

PurposeThis paper aims to investigate how organization capital influences different forms of corporate risk. It also explores how the relationship between organization capital and risks varies in the cross-section of firms.Design/methodology/approachTo test the hypothesis, this study employs the ordinary least squares (OLS) regression model using a large sample of the United States (US) data over the 1981–2019 period. It also uses an instrumental variable approach and an errors-in-variables panel regression approach to mitigate endogeneity problems.FindingsThe empirical results show that organization capital is positively related to both idiosyncratic risk and total risk but negatively related to systematic risk. The cross-sectional analysis shows that the positive relationship between organization capital and idiosyncratic risk is significantly more pronounced for the subsample of firms with high information asymmetry and human capital. Moreover, the negative relationship between organization capital and systematic risk is significantly more pronounced for firms with greater efficiency and firms facing higher industry- and economy-wide risks.Practical implicationsThe findings have important implications for investors and policymakers. For example, since organization capital increases idiosyncratic risk and total risk but reduces systematic risk, investors should take organization capital into account in portfolio formation and risk management. Moreover, the findings lend support to the argument on the recognition of intangible assets in financial statements. In particular, the study suggests that standard-setting bodies should consider corporate reporting frameworks to incorporate the disclosure of intangible assets into financial statements, particularly given the recent surge of corporate intangible assets and their critical impact on corporate risks.Originality/valueTo the best of the authors' knowledge, this is the first study to adopt a large sample to provide systematic evidence on the relationship between organization capital and a wide range of risks at the firm level. The authors show that the effect of organization capital on firm risks differs remarkably depending on the kind of firm risk a particular risk measure captures. This study thus makes an original contribution to resolving competing views on the effect of organization capital on firm risks.
Investigation on dynamic mathematical model and control method of flue gas heat exchange system
Authors: Ma Hongqiang , Xie Yue , Song Xingpeng , Liu Yu , Luo Xinmei , Wang Shengxun 
Published: March 2023

PurposeThe purpose of this paper is to recover the waste heat of flue gas heat exchanger (FGHE) as efficiently as possible and avoid the acid dew corrosion of that.Design/methodology/approachA novel flue gas waste heat recovery system was proposed in the paper. The dynamic mathematical models of key equipment in that were established based on theory and experiment method. The proportion integration differentiation-differentiation (PID-P) cascade control method based on particle swarm optimization algorithm was used to control the outlet temperature of FGHE. The dynamic characteristics of the flue gas heat exchange system were simulated by the particle swarm optimization algorithm with different fitness functions.FindingsThe PID-P temperature controller parameters can be quickly and effectively obtained by the particle swarm optimization algorithm based on the fitness function of integral time absolute error (ITAE). The overshoot, rise time and adjusting time of the novel system are 2, 83 and 105s, respectively. Compared with the traditional two-step tuning (T-ST) method, the novel system is better in dynamic and steady-state performance. The overshoot and the adjustment time of the system are reduced by 44% and 328s, respectively. ITAE is a performance evaluation index for control system with good engineering practicability and selectivity.Originality/valueThe dynamic mathematical model of key equipment in the new flue gas waste heat recovery system is established and the system's control strategies and methods are explored.
Workers’ mobility across occupations: Complementary insights from the human capital, migration and social stratification literature.
Authors: Cardoso Ben Hur Francisco , Hartmann Dominik 
Published: March 2023

PurposeA growing body of literature shows how intragenerational occupational mobility affects economic dynamics and social stratification. In this article the authors aim to carry out a structured review of this literature, outlining a systemic overview for more comprehensive research and public policies.Design/methodology/approachThe authors use methods from structured literature reviews and network science to reveal the segmented research landscape of occupational mobility literature. The authors made an in-depth analysis of the most important papers to summarize the main contributions of the literature and identify research gaps.FindingsThe authors reveal a segmented research landscape around three communities: (1) human capital theory, (2) social stratification theory and (3) migration studies. Human capital research uses microfounded mathematical modeling to understand the relationship between skills and mobility. Nevertheless, it cannot explain social segregation and generally does not focus on the importance of local labor demand. Social stratification research can explain the social and institutional barriers to occupational mobility. Migration research studies the relationship between migration, labor demand and social mobility.Originality/valueThis paper is the first literature review that uses network analysis to perform a systematic review of the intragenerational occupational mobility literature. Moreover, this review identifies opportunities for mutual learning and research gaps in the research landscape.
Process ambidexterity driven by environmental uncertainty: balancing flexibility and routine
Authors: Yu Kangkang , Cadeaux Jack , Luo Ben Nanfeng , Qian Cheng 
Published: March 2023

PurposeThis study aims to extend ambidexterity theory from the perspective of organisational learning and examine how process ambidexterity, which comprises operational flexibility and operational routine, responds to environmental uncertainty and ultimately reduces organisational risks.Design/methodology/approachThis study tests the hypotheses by analysing 464 annual reports of 115 listed companies in the Chinese agricultural and food industry using content and secondary data analyses. Four case studies are also provided.FindingsThe results show that (1) environmental uncertainty has a positive effect on either operational flexibility or operational routine; (2) both operational flexibility and operational routine have negative effects on organisational risks, supporting the view that process ambidexterity mediates the relationship between environmental uncertainty and organisational risks; and (3) organisational slack plays the role of “double-edged sword” by negatively moderating the effect of environmental uncertainty on operational flexibility and positively moderating the effect of environmental uncertainty on operational routine.Originality/valueIn an uncertain environment, companies are exposed to greater risk. This study contributes to risk management in three ways: first, it extends ambidexterity theory to process management and proposes how process ambidexterity balances operational flexibility and routines. Second, it distinguishes between the different conditions under which flexibility or routines are superior. Third, it explains the mechanisms related to how organisations can resolve environmental uncertainty into risk through process ambidexterity.
Specialist courts and borderline personality disorder: a pilot study of the efficacy of the assessment and referral court list to reduce recidivist behaviour
Authors: Chesser Brianna , Smith Ken , Sigamoney Alyssa , Becker Casey 
Published: March 2023

Purpose
This paper aims to examine the ways in which the criminal justice system has evolved to accommodate mental illness. Mental health courts are one such alternative; these courts actively seek rehabilitative and therapeutic outcomes for participants. However, current literature suggests that these courts are ineffective for offenders who have been diagnosed with borderline personality disorder (BPD).

Design/methodology/approach
The aim of the current inquiry was to determine the degree to which participation in the Assessment and Referral Court (ARC) List in the Magistrates’ Court of Victoria reduced re-offending rates for offenders diagnosed with BPD by providing a comparative analysis of pre and post ARC List offending.

Findings
The results of a two-year recidivism study suggest that successful completion of the ARC List reduces recidivism for 50% of offenders diagnosed with BPD.

Originality/value
To the authoring team’s knowledge, this is the second paper to explore the efficacy of the Assessment of Referral Court List (Magistrates’ Court of Victoria) in reducing recidivist behaviours for programme participants; however, it is the first paper to look specifically at the recidivist behaviours of participants of the Assessment of Referral Court List (Magistrates’ Court of Victoria) who have been diagnosed with BPD.
Service performance reporting and principles-based authoritative guidance: an analysis of New Zealand higher education institutions
Authors: Hsiao Pei-Chi Kelly , Low Mary , Scott Tom 
Published: March 2023

PurposeThis paper aims to examine the extent to which performance indicators (PIs) reported by New Zealand (NZ) higher education institutions (HEIs) correspond with accounting standards and guidance and the effects issuance of principles-based authoritative guidance and early adoption of Public Benefit Entity Financial Reporting Standard 48 (PBE FRS 48) have on the PIs disclosed.Design/methodology/approachUsing a content analysis index derived from accounting standards and guidance, we conduct a longitudinal assessment of the 2016 and 2019 statements of service performance published by 22 NZ HEIs.FindingsThe PIs reported extend beyond the service performance elements proposed by standard-setters. Despite few indicators on intermediate and broader outcomes, the measures disclosed by HEIs are reflective of their role in the NZ economy and the national Tertiary Education Strategy. The results show that principles-based authoritative guidance and early adoption of PBE FRS 48 influence the focus and type of measures disclosed, while there is no evidence of improvements in the reporting of impacts, outcomes and information useful for performance evaluation.Practical implicationsThis paper provides timely insights for standard-setters and regulators on the influence principles-based accounting standards and guidance have on non-financial reporting practices.Originality/valueThis study contributes to the scant literature on HEIs’ service performance reporting. It presents a model for conceptualising HEIs’ PIs that can be used as a basis for future research on non-financial reporting. It also reflects on the tension between accountability and “accountingisation”, suggesting that, although the PIs reported support formal accountability, they do not communicate whether HEIs’ activities and outputs meet their social purpose.
Identifying key mentor characteristics for successful workplace mentoring relationships and programmes
Authors: Deng Connie , Turner Nick 
Published: March 2023

PurposeThe aims of this critical review are to identify the mentor characteristics that lead to superior mentoring outcomes and to provide human resources development (HRD) professionals with evidence-based suggestions for recruiting, selecting and training mentors to improve mentorship programme effectiveness.Design/methodology/approachThe authors conducted a critical review of existing quantitative research on mentor characteristics that have an impact on effective mentoring.FindingsThe authors identified five key categories of mentor characteristics linked to successful mentoring outcomes: competency in context-relevant knowledge, skills and abilities; commitment and initiative; interpersonal skills; pro-social orientation and an orientation toward development, exploration and expansion.Research limitations/implicationsThere is limited research on the characteristics of ineffective mentor characteristics, exclusion of articles that used qualitative research methods exclusively and how technology-based communication in mentoring may require different characteristics. Most of the included studies collected data in the United States of America, which may exclude other important mentor characteristics from other non-Western perspectives.Practical implicationsTo ensure that there is both a sufficient pool of qualified mentors and mentors who meet the desired criteria, focus on both recruitment and training mentors is important. Incorporating the desired mentor characteristics into both of these processes, rather than just selection, will help with self-selection and development of these characteristics.Originality/valueDespite the ongoing interest in identifying effective mentor characteristics, the existing literature is fragmented, making this challenging for HRD professionals to determine which characteristics are crucial for mentoring relationships and programme success. Addressing this practical need, this critical review synthesises the research literature and identifies patterns and inconsistencies. Based on the review, the authors provide evidence-based recommendations to enhance the recruitment, selection and training of mentors.
Adoption of sustainable practices by Asian hotels: gaps in academia
Authors: Srivastava Sidharth , Dey Sandeep Kumar , Sharma Savita , Ratilla Mark 
Published: March 2023

PurposeAn extant literature review of hospitality manpower performance reveals the scarcity of green skills among young graduates of hospitality management in the Asian context. Studies signal the discrepancy between knowledge imbibed and skills acquired. The current study is a call to action to identify the barriers to green training at the academic level.Design/methodology/approachThe paper is based on a qualitative investigation by senior academics from Asian countries. Thematic analysis is the primary method deployed.FindingsFour major themes emerged from the analytical exercise. They include lack of resources, policies and regulations, an overburdened curriculum and awareness. Interestingly, the themes are in tandem with the Tourism Education Futures Institute (TEFI) value framework for nurturing sustainability practices in the hospitality industry through systematic programming of hotel management education.Practical implicationsIn order to meet the United Nations Sustainable Development Goal 2030 (Goal 4) of ensuring lifelong strategic education to foster sustainability, the green skill–knowledge gap must be bridged at the academic level. The current paper sheds light on how the synergy between industry and academia can address this knowledge–skill gap and develop sustainable capacities in the long run.Originality/valueThis study used a qualitative dataset, and the findings contribute to the sustainability literature. Further studies can be undertaken using big data in varied settings.
Non‐linear response of productivity to precipitation extremes in the Inner Mongolia grassland
Authors: Sun Jiamei , Zhang Bin , Pan Qingmin , Liu Wei , Wang Xiaoliang , Huang Jianhui , Chen Dima , Wang Changhui , Han Xingguo 
Published: March 2023

Abstract

As precipitation (PPT) regimes are becoming more extreme worldwide, the inter‐annual variation in PPT amount at a given location is becoming greater than ever before. Yet, our understanding of grassland responses to extreme drought and wet years, as well as the pattern of the relationship between PPT and above‐ground net primary productivity (ANPP) along a PPT gradient from extreme drought to extreme wetness scenarios, remains unclear, hampering accurate forecasting of the grassland feedbacks to future PPT changes.

We addressed this research gap by a 4‐year, multi‐level PPT gradient experiment that included PPT amounts simulating extremely dry and wet years in combination with a long‐term (40 years) observational study in a grassland ecosystem.

We found that the ANPP reductions due to extreme droughts were greater than the magnitude of positive responses to extreme wet years. The PPT‐ANPP relationship along the gradient of PPT followed a negative asymmetric (concave‐down) pattern. We identified the major mechanisms for this pattern were a shift in primary limiting resource for ANPP from water to nitrogen with increasing PPT and different responses of the plant functional groups presented in the community. With the increase of PPT from extremely low to extremely high levels, the relative abundance of forbs increased, while that of grasses decreased and annuals was not significantly affected.

This study illustrates how a grassland responded to PPT extremes and highlights the role of shifts in resource limitation in affecting the PPT‐ANPP relationship. The negative asymmetric pattern suggests that the reduction of ANPP in extremely drought years cannot be mitigated by its positive response to extremely wet years. Thus, to accurately forecast future ecosystem feedback to climate change, we should take into account the negative asymmetric feature of the ecosystem response to stronger climate variation, as well as recognize that the resource limitations will be fundamentally altered by increasing frequency and intensity of climate extremes in the future.

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