bluuebunny/crossref_metadata_2025_split huggingface dataset:
Well‐Balanced Ambipolar Charge Transport of Diketopyrrolepyrrole‐Based Copolymers: Organic Field‐Effect Transistors and High‐Voltage Logic Applications
Authors: Xuyao Song , Kim Sang Beom , Jung Hanggyo , Kim Jaekyum , Mo Jaewan , Jeong Yong Jin , Jang Jaeyoung , An Tae Kyu , Kim Yun‐Hi , Jeon Jongwook 
Published: July 2023

AbstractA poly (3,6‐bis(thiophen‐2‐yl)−2,5‐bis(2‐decyltetradecyl)−2,5‐dihydropyrrolo[3,4‐c]pyrrole‐1,4‐dione‐co‐(2,3‐bis(phenyl)acrylonitrile)) (PDPADPP) copolymer, composed of diketopyrrolopyrrole (DPP) and a cyano (nitrile) group with a vinylene spacer linking two benzene rings, is synthesized via a palladium‐catalyzed Suzuki coupling reaction. The electrical performance of PDPADPP in organic field‐effect transistors (OFETs) and circuits is investigated. The OFETs based on PDPADPP exhibit typical ambipolar transport characteristics, with the as‐cast OFETs demonstrating low field‐effect hole and electron mobility values of 0.016 and 0.004 cm2 V−1 s−1, respectively. However, after thermal annealing at 240 °C, the OFETs exhibit improved transport characteristics with highly balanced ambipolar transport, showing average hole and electron mobility values of 0.065 and 0.116 cm2 V−1 s−1, respectively. To verify the application of the PDPADPP OFETs in high‐voltage logic circuits, compact modeling using the industry‐standard small‐signal Berkeley short‐channel IGFET model (BSIM) is performed, and the logic application characteristics are evaluated. The circuit simulation results demonstrate excellent logic application performance of the PDPADPP‐based ambipolar transistor and illustrate that the device annealed at 240 °C exhibits ideal circuit characteristics.
Strategic cooperation of live‐stream platform in e‐commerce
Authors: Wang Shanshan , Guo Xin 
Published: July 2023

AbstractMany live‐stream platforms (LSPs) have sought cooperation with e‐tailers or/and manufacturers. Considering the existing cooperation modes, we propose models to examine the optimal cooperation mode. Our study shows that the LSP benefits from cooperating with both firms. Moreover, the manufacturer profits from the LSP only cooperating with itself, while the e‐tailer may profit from the LSP only cooperating with itself or the manufacturer. The consumers benefit from the LSP only cooperates with one firm. We further consider the case where the manufacturer's LS channel is not inferior to the e‐tailer's channels and examine the equilibrium strategies for players and consumers.
Longitudinal Meta‐Analysis of Historical Parkinson's Disease Trials to Inform Future Trial Design
Authors: Arshad Usman , Rahman Fatima , Hanan Nathan , Chen Chao 
Published: July 2023

AbstractBackgroundThe outcome of clinical trials in neurodegeneration can be highly uncertain due to the presence of a strong placebo effect.ObjectivesTo develop a longitudinal model that can enhance the success of future Parkinson's disease trials by quantifying trial‐to‐trial variations in placebo and active treatment response.MethodsA longitudinal model‐based meta‐analysis was conducted on the total score of Unified Parkinson's Disease Rating Scale (UPDRS) Parts 1, 2, and 3. The analysis included aggregate data from 66 arms (observational [4], placebo [28], or investigational‐drug‐treated [34]) from 4 observational studies and 17 interventional trials. Inter‐study variabilities in key parameters were estimated. Residual variability was weighted by the size of study arms.ResultsThe baseline total UPDRS was estimated to average at 24.5 points. Disease score was estimated to worsen by 3.90 points/year for the duration of the treatments; whilst notably, arms with a lower baseline progressed faster. The model captured the transient nature of the placebo response and sustained symptomatic drug effect. Both placebo and drug effects peaked within 2 months; although, 1 year was needed to observe the full treatment difference. Across these studies, the progression rate varied by 59.4%, the half‐life for offset of placebo response varied by 79.4%, and the amplitude for drug effect varied by 105.3%.ConclusionThe longitudinal model‐based meta‐analysis describes UPDRS progression rate, captures the dynamics of the placebo response, quantifies the effect size of the available therapies, and sets the expectation of uncertainty for future trials. The findings provide informative priors to enhance the rigor and success of future trials of promising agents, including potential disease modifiers. © 2023 GSK. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Treatment Detection and Movement Disorder Society‐Unified Parkinson's Disease Rating Scale, Part III Estimation Using Finger Tapping Tasks
Authors: ZhuParris Ahnjili , Thijssen Eva , Elzinga Willem O. , Makai‐Bölöni Soma , Kraaij Wessel , Groeneveld Geert J. , Doll Robert J. 
Published: July 2023

AbstractThe validation of objective and easy‐to‐implement biomarkers that can monitor the effects of fast‐acting drugs among Parkinson's disease (PD) patients would benefit antiparkinsonian drug development. We developed composite biomarkers to detect levodopa/carbidopa effects and to estimate PD symptom severity. For this development, we trained machine learning algorithms to select the optimal combination of finger tapping task features to predict treatment effects and disease severity. Data were collected during a placebo‐controlled, crossover study with 20 PD patients. The alternate index and middle finger tapping (IMFT), alternative index finger tapping (IFT), and thumb–index finger tapping (TIFT) tasks and the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) III were performed during treatment. We trained classification algorithms to select features consisting of the MDS‐UPDRS III item scores; the individual IMFT, IFT, and TIFT; and all three tapping tasks collectively to classify treatment effects. Furthermore, we trained regression algorithms to estimate the MDS‐UPDRS III total score using the tapping task features individually and collectively. The IFT composite biomarker had the best classification performance (83.50% accuracy, 93.95% precision) and outperformed the MDS‐UPDRS III composite biomarker (75.75% accuracy, 73.93% precision). It also achieved the best performance when the MDS‐UPDRS III total score was estimated (mean absolute error: 7.87, Pearson's correlation: 0.69). We demonstrated that the IFT composite biomarker outperformed the combined tapping tasks and the MDS‐UPDRS III composite biomarkers in detecting treatment effects. This provides evidence for adopting the IFT composite biomarker for detecting antiparkinsonian treatment effect in clinical trials. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
The effectiveness of motivation‐guided PDCA cycle nursing for self‐management ability and outcomes of patients with gestational diabetes mellitus
Authors: Zhao Mingxia , Li Haixiang , Wang Jing , Chu Limin , Huang Lixia , Li Hailian 
Published: July 2023

AbstractAimTo explore the effectiveness of motivation‐guided ‘plan, do, check and action’ cycle nursing for self‐management ability and outcomes of patients with gestational diabetes mellitus (GDM).DesignA pre‐ and post‐ comparison quasi experimental study.MethodsTotally 108 pregnant women with GDM diagnosed and delivered in our hospital from January 2020 to April 2021 were included in this study. They were divided into study group (54 cases) and control group (54 cases).ResultsThe score of self‐management ability were significantly higher than those of control group (t‐test, all p < 0.05), as well as themselves before interventions in both groups (t‐test, all p < 0.05). Besides, scores of anxiety, depression, extraverted stimulus and intraverted stimulus all achieved significant reduction after interventions in study group compared with control one (t‐test, all p < 0.05), as well as themselves before interventions in both groups (t‐test, all p < 0.05).Patient or Public ContributionNo patient or public contribution.
The effect of social devaluation, labeling, and familiarity on children's attitudes and behavioral intentions toward a peer with symptoms of ADHD
Authors: Greenway Charlotte W. , Robinson Ammanys H. , King Janice M. 
Published: July 2023

AbstractThe present study examined the attitudes and behavioral intentions of 336 children aged 7–11 toward a hypothetical peer with symptoms of attention‐deficit hyperactivity disorder (ADHD) to determine whether they were influenced by labeling, social devaluation, or familiarity. Children read one of five vignettes describing the behavior of a gender‐neutral peer before completing self‐report measures of attitudes and behavioral intentions. Results showed children held predominantly negative attitudes toward the hypothetical peer, which were more pronounced for inattentive than hyperactive/impulsive symptoms. These findings suggest that children were more likely to devalue internalizing rather than externalizing behaviors. Children also reported being more likely to engage in active/recreational and social activities rather than academic activities. In addition, the diagnostic label “ADHD” led to more negative attitudes and behavioral intentions, while knowing someone with ADHD mediated the negative effect of hyperactive/impulsive symptoms on attitudes and behavioral intentions. Finally, significant positive relationships were found between attitudes and children's willingness to engage in social, academic, and physical activities. Policy and practice implications of these findings are discussed.
Maleimidophenyl isocyanates adducts as versatile post‐polymerization modification agents for biobased furan polymers
Authors: Takashima Rikito , Aoki Daisuke , Otsuka Hideyuki 
Published: July 2023

AbstractBiobased furan polymers (BFPs) derived from 5‐hydroxymethylfurfural (HMF) are eco‐friendly polymers obtained from inedible biomass resources. Modification of such polymers is expected to expand their practical uses. BFPs have furan moieties that can react as dienophiles with maleimide, facilitating well‐designed polymer reactions. Herein, we report the preparation of various maleimides using p‐maleimidophenylisocyanate (PMPI), which has a highly reactive isocyanate group and a maleimide group, to modify BFP through the Diels–Alder reaction of the maleimide group. Two reactive sites in PMPI exhibit orthogonal reactivity, enabling us to achieve tailor‐made modification agents. The Tg values and rheological properties of modified polymers can be tuned according to the structure of maleimide and their reaction conversion, which demonstrates the practical usability of BFP derived from furfural. The strategy proposed herein can be applied to obtain biobased materials with desirable functions and physical properties.
Histologic features and decreased lung FOXF1 gene expression in severe bronchopulmonary dysplasia without a genetic diagnosis of alveolar capillary dysplasia
Authors: Galambos Csaba , Logan J. Wells , Stankiewicz Pawel , Szafranski Przemyslaw , Zalles Carola , Gonzales Jose , Nath Sfurti , Patel Shalinkumar , Abman Steven H. 
Published: July 2023

AbstractWe report the case of a preterm infant who died at 10 months of age with severe bronchopulmonary dysplasia (sBPD) with refractory pulmonary hypertension and respiratory failure who had striking histologic features compatible with the diagnosis of alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) but without genetic confirmation of the diagnosis. We further demonstrate dramatic reductions in lung FOXF1 and TMEM100 content in sBPD, suggesting common mechanistic links between ACDMPV and sBPD with impaired FOXF1 signaling.
Effect of long term noninvasive ventilation in children on parent's quality of life
Authors: Sanctis Livio , Khirani Sonia , Vedrenne‐Cloquet Meryl , Griffon Lucie , Cozzo Mathilde , Olmo Arroyo Jorge , Sidhoum Lynda , Ouss Lisa , Fauroux Brigitte 
Published: July 2023

AbstractObjectiveImproving or maintaining the quality of life of the family of children treated with long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) is a major concern; but studies are scarce. The aim of the study was to evaluate the impact of long term CPAP or NIV in children on anxiety, depression, quality of sleep, and quality of life of their parents.MethodsValidated questionnaires evaluating anxiety and depression (hospital anxiety and depression scale), sleep quality (Pittsburgh sleep quality index), daytime sleepiness (Epworth sleepiness scale), and parents' quality of life (PedsQL family impact module) were completed by parents of children who were started on CPAP/NIV before (M0) and after 6−9 months (M6) of treatment.ResultsThe questionnaires of 36 parents (30 mothers, 6 fathers) of 31 children were analyzed. For the entire group, no significant change was observed in anxiety, depression, sleep quality, daytime sleepiness, and quality of life between M0 and M6. When analyzing questionnaire class changes between M0 and M6: anxiety was relieved in 23% of parents and worsened in 29%, depression was relieved in 14% and worsened in 20%, sleep quality improved in 43% and worsened in 27%, sleepiness improved in 26% and worsened in 17%, with no change in the other parents.ConclusionLong term CPAP/NIV in children had no significant effect on parents' anxiety, depression, sleep quality, and quality of life.
Study on the blast impulse characters of high explosive charge with reactive metal casing
Authors: Du Ning , Zhang Xiangfeng , Xiong Wei , Liu Chuang , Tan Mengting 
Published: July 2023

AbstractThis paper focuses on the blast impulse characters of high explosive charge with reactive metal casing. Explosive driving experiments were carried out for high explosive charge with different thicknesses of reactive metal casings and traditional 2 A12 aluminum alloy casings. The power of charge with the two casings was evaluated by analyzing the deformation of 0.3 mm thick Q235 steel foil under the action of the shock wave. Based on the principle of energy conservation, the deflection calculation model of steel foil under explosion load was established. The maximum deflection of plastic deformation of steel foil at different distances under the action of explosive loading caused by the charge with different material casing was calculated. The characteristics of the steel foil damaged by the explosion shock wave generated by the charge with a reactive metal casing were analyzed and compared with the blast impulse of the charge with the traditional 2 A12 aluminum alloy casing. The results show that, with the increase of the thickness of the reactive metal casing, the maximum deflection of the plastic deformation of the steel foil increased, that is, the damage effect to the target improved. The theoretical model of the maximum deflection of plastic deformation of steel foil under explosive loading can accurately predict the deflection of steel foil under explosive loading, and provide a theoretical basis for evaluating the damage effect of reactive materials driven by the explosion. The experimental results showed that the reactive metal casing has a good application prospect in realizing high‐efficiency damage.
Bilateral endobronchial metastases from hepatocellular carcinoma (HCC): A case report with literature review
Authors: Koay Leping , Lee Hwei Yee , Xu Huiying , Phua Chee Kiang 
Published: July 2023

AbstractHepatocellular carcinoma presenting with endobronchial metastases is extremely rare, with less than 15 cases reported over the last 4 decades. We describe a case of a 62‐year‐old male who first presented with pulmonary symptoms secondary to bilateral endobronchial metastatic disease from newly diagnosed hepatocellular carcinoma.
Betanin inhibits PI3K/AKT/mTOR/S6 signaling pathway, cell growth and death in osteosarcoma MG‐63 cells
Authors: Liu Jichao , Velu Periyannan , Vijayalakshmi Annamalai , Zareian Mohsen , Xi Haitao 
Published: July 2023

AbstractIt is possible to develop new chemopreventive compounds so that cancer cells can be targeted in an exclusive manner. Bioactive natural compounds have demonstrated to be efficient chemotherapeutic agents, safe and cost‐effective. Majority of anti‐cancer medications are derived from natural sources, particularly of plant origins. Betanin (betanidin‐5‐O‐β‐glucoside) is the most common betacyanin with antioxidant, anti inflammatory and anticancer properties. The present study therefore investigated the effect of betanin onosteosarcoma MG‐63 cells. The mechanistic pathway of inflammatory responses, cell proliferation and apoptosis were investigated. The MG‐63 cells were treated with betanin for 24 h. Betanin actions on the appearance of cell arrangements, morphological changes, ROS induced Δψm, cell migration, cell adhesion and proliferative mechanistic marker expression of PI3K/AKT/mTOR/S6were analyzed. Betanin inhibited MG‐63 cells at IC50 concentrations between 9.08 and 54.49 μM and induced apoptosis by triggering the ROS mechanism. Betanin inhibited proliferation and migration of MG‐63 cells and induced DNA fragmentation. Betanin also modified the key mediator expression levels of PI3K/AKT/mTOR/S6 signaling pathways. Betanin can potentially be utilized in bone carcinoma therapeutics to inhibit, reverse or delay osteosarcoma.
Black Immigrant Literacies and the Promise of Unbroken Englishes: Five Things Every Teacher Should Know and Can Do
Authors: Smith Patriann 
Published: July 2023

Abstract“Black immigrant literacies” is an intersectional framework that draws from diaspora literacy, racial literacy, and transnational literacy to center race and present teachers with a lens that can support Black immigrant students and their peers' literacies in classrooms. Black immigrant youth can be described as first‐, second‐, or third‐generation immigrants to the United States who identify as Black and who migrate to the United States from Africa, the Caribbean, or elsewhere. Many students from the Black immigrant population, though largely “invisible,” tend to be regarded as anew model minorityand asdesigner immigrants. New model minority perceptions of Black immigrants persist because of claims of immigrant superiority and because Black immigrants have long been perceived as having socioeconomic advantages over their Black American peers. Given that Black immigrants originate primarily from the Caribbean or Africa, accounting for over half of all Black foreign‐born people in the United States, and considering that the Caribbean remains the most common region of birth for the over 4 million Black immigrants in the United States, accounting for almost half of the total, I paint a selective portrait of the intersectionalities surrounding Black immigrant literacies as a basis for teachers to better understand Black immigrant students' needs in classrooms. I also draw specifically from Black Caribbean immigrant literacies to identify and describe five things that every teacher should know and can do when encountering Black Caribbean in English language arts and literacy instruction. Through provisions such as legitimizing “unbroken Englishes,” supporting “translanguaging with Englishes,”cultivating “holistic literacies,”and fostering “local–global connections,”it is anticipated that teachers of Black immigrants in the United States, Caribbean, and beyond will begin to unmask invisibility of this population in their classrooms. Through the use of this framework, it is also expected that teachers will be able to better support all students who engage with the literacies of Black immigrants in United States schools.
Screening for aroma in rice genotypes with African and Asian backgrounds
Authors: Ndikuryayo Cyprien , Ndayiragije Alexis , Kilasi Newton , Kusolwa Paul 
Published: July 2023

AbstractAromatic rice is highly preferred by consumers and has an important market worldwide. The demand for aromatic rice is high in East African countries, mainly in urban areas. Among the rice varieties that are grown in Burundi, few of them have a slight aroma which is not enough to satisfy the consumers’ demand and preference. There is no published report on the status of aroma in locally grown varieties and breeding lines in Burundi yet. This study aimed to identify aromatic genotypes that can be used in the breeding program to meet preferences of consumers. Two hundred fifteen genotypes were subjected to kompetitive allele‐specific PCR genotyping and sensory evaluation methods. Fifty‐three genotypes had the betaine aldehyde dehydrogenase (BADH2) gene for fragrance and displayed different levels of aroma expression. The sensory evaluation revealed two strongly aromatic genotypes, 43 moderately aromatic genotypes, 131 slightly aromatic genotypes, and 32 nonaromatic genotypes.The results of this study showed that BADH2 gene is significantly associated with rice aroma in accordance with previous reports. Furthermore, aroma and taste were positively and significantly correlated. Strongly aromatic genotypes (SUPA KATRIN and SUPA DE NYANZA –LAC) having the BADH2 gene for fragrance are of great interest for use in the breeding program to improve rice varieties to meet consumers' preferences in Burundi.
A randomized controlled trial on triamcinolone versus saline impregnated merocel post endoscopic sinus surgery: Our experience in a tertiary care centre
Authors: Sood Ananya , Goel Khushboo , Bhagat Sanjeev , Sahni Dimple , Sharma Dinesh Kumar , Yadav Vishav 
Published: July 2023

AbstractPurposeTo assess the potential benefit of impregnating Merocel (a non‐absorbable nasal dressing) with a topical steroid solution, for use as a direct and slow local delivery system of steroids after sinus surgery to improve postoperative wound healing.MethodsIn this randomized controlled trial, 40 patients with bilateral chronic rhinosinusitis with nasal polyposis were subjected to functional endoscopic sinus surgery. Following the completion of the surgery, Merocel packs were inserted in the bilateral nasal cavities and infiltrated with 4 mL triamcinolone (40 mg/mL) in one nasal cavity (treatment group) and 4 mL normal saline in the other (control group). Nasal packs were removed on the third postoperative day and postoperative healing assessment was done on postoperative Weeks 1, 2, 4, and 12. The findings were noted as per Lund Kennedy (LKES) and perioperative sinus endoscopy (POSE) scores and compared on both sides.ResultsSignificant (P < 0.05) improvement was noted in Lund Kennedy score for crusting and polyp at Week 12, for edema at Week 1, and nasal discharge at Weeks 1 and 12, but there was no significant improvement in scarring at any week. Overall, the difference between the treatment and control arms was statistically significant at all postoperative visits except at Week 4. Also, there was a significant improvement in POSE scores at Weeks 1, 2, and 12 but not at Week 4.ConclusionThis study positively concludes that the nasal cavity packed with drug‐soaked packs had less scarring and edema in the postoperative period and the overall wound healing was much better as compared to saline‐soaked packs.