bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail
Authors: Godwin Joshua S. , Michel J. Max , Mobley C. Brooks , Nader Gustavo A. , Roberts Michael D. 
Published: January 2025

AbstractWhile total RNA concentrations putatively represent ribosome content, there is a need to homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) provided through UV–Vis spectroscopy (UV), fluorometry‐only (Fluor), and fluorometry‐based microfluidic chip electrophoresis (MFGE) were examined in C2C12 myotubes and mouse skeletal muscle to determine if values aligned with [18S + 28S rRNA] (i.e., criterion ribosome metric). A novel antibody cocktail (termed RiboAb) was also tested and compared to [18S + 28S rRNA] in these models. In myotubes, 24‐h IGF‐1 treatments increased [18S + 28S rRNA] (~2.0‐fold) and [RNA] based on UV (~1.9‐fold), Fluor (~2.3 fold), and MFGE (~2.1‐fold). In C57BL/6 mice, 10 days of mechanical overload (MOV) elevated plantaris [18S + 28S rRNA] (~1.7‐fold) and [RNA] according to UV (~1.5‐fold), Fluor (~1.6‐fold), and MFGE (~1.8‐fold). Myotube and mouse plantaris RiboAb levels were significantly higher with IGF‐1 treatments and MOV, respectively, versus controls (1.3‐fold and 1.7‐fold, respectively), and values correlated with [18S + 28S rRNA] (r = 0.637 and r = 0.853, respectively, p ≤ 0.005). UV, Fluor, and MFGE [RNA] are seemingly valid surrogates of cell/tissue ribosome content, although each method has advantages (e.g., ease of use) and disadvantages (e.g., magnitudes of bias) discussed herein. Finally, the RiboAb cocktail may also represent ribosome content, although this should be further explored in other models.
Network pharmacological analysis and in vitro testing of the rutin effects on triple-negative breast cancer
Authors: Chang Cheng , Jia Ruiying , Fang Bin , Miao Yaoyao , Zhang Lili 
Published: January 2025

Abstract

Objectives
This study aims to assess the potential mechanism of rutin to treat triple-negative breast cancer (TNBC) based on network pharmacology followed by in vitro experiments.

Methods
The potential rutin targets were predicted, and the DisGeNET database was used to obtain the disease targets. The intersection targets were identified with Venny 2.1 software, with the String database subsequently used as input to produce the “drug-target-disease” visual network employing Cytoscape 3.7.2. Gene ontology. Kyoto Encyclopaedia of Genes and Genomes analyses were performed for intersection targets, while AutoDock Vina was used for molecular docking and visualization. Cell viability was assessed using the Colorimetric CCK-8 test, and apoptosis was analyzed using PI/Annexin V. The predicted core targets were confirmed by qPCR and western blotting assays.

Results
EGFR, IL6, TNF, and INS were found as the primary targets. The molecular docking analysis revealed the rutin interaction with the core targets. The in vitro results confirmed that rutin inhibited the growth of the MDA-MB-231 cell line. Rutin also induced cell death and decreased the expressions of IL6, TNF, INS, and EGFR.

Conclusion
Rutin’s multi-target effects and molecular mechanism for treating TNBC were confirmed through preliminary results. The results provide a theoretical base for rutin’s possible function in breast cancer treatment.
Reference dietary patterns in Portugal: Mediterranean diet vs Atlantic diet
Authors: Guiné Raquel P. F. , Florença Sofia G. , Amaral Ana Luisa , Costa Cristina A. 
Published: January 2025

Abstract
Portugal is influenced by the Atlantic Ocean to the west and the Mediterranean Sea to the south. Thus, the dietary patterns in Portugal include both the Mediterranean diet (MD) and the Atlantic diet (AD). This review examines the characteristics of both diets, highlighting their commonalities and unique features. This descriptive literature review analyses scientific articles on the MD and AD. It addresses the health effects of both diets based on published evidence. It includes a review of 15 studies specifically focused on the Portuguese population. Most of the studies were conducted with younger people (children or adolescents) or older people, and some were made with patients suffering from a specific pathology, like heart disease, AIDS, or macular degeneration. Both diets emphasize natural, local, and seasonal foods prepared using traditional methods. They consist of foods rich in macronutrients, micronutrients, and bioactive compounds that offer health benefits. Both the MD and the AD are recommended as healthy diets, associated with physical activity as fundamental elements of a healthy lifestyle promoting general well-being. While the health effects of the MD have been extensively studied, the AD remains under-researched.
Impact of fiber treatment and electron beam radiation on the properties of ethylene-propylene-diene rubber composites reinforced with banana fiber
Authors: Radi Hamdi , Helal Reham H. , Elmesallamy Salwa M. 
Published: January 2025

Abstract
Composites based on ethylene-propylene-diene rubber (EPDM) were prepared using a mechanical rotary mill. EPDM loaded with 10 phr (part per hundred part of rubber) banana fiber (BF) treated with potassium permanganate (KMNO4), maleic anhydride (MA), or silane. These composites were subjected to various electron beam radiation doses up to 150 kGy. The physical, mechanical, and thermal properties of these composites as a function of irradiation dose were investigated. Ionizing radiation led to a significant improvement in the properties of all compositions. Besides, an improvement in the mechanical properties was attained with the addition of treated banana fiber especially that treated with silane.
állampolgári nevelés és a társadalmi innováció kapcsolata
Authors: Nyúl Eszter Anna 
Published: January 2025

Jelen tanulmány a neveléstudományi doktori kutatás során kidolgozott „nem formális állampolgárságra nevelési modell” fogalmi keretének elméleti hátterét ismerteti. Szekunder kutatás, ami a releváns szakirodalom összegyűjtését és elemző szintetizálását végezte el, és amely a Kozma féle társadalmi innováció felfogásra épül. A társadalmi innováció, a civil kezdeményezés és az állampolgárságra nevelés kapcsolódási területeit tárja fel, melyben jelen van a tudatosan megélt állampolgárság és annak közösségi tanulás útján történő fejlesztése. Ez utóbbira úgy tekintünk, mint a társadalmi innováció céljára és egyben eszközére: az aktív, demokratikus állampolgár kompetenciái hasznosulnak a közösségi problémamegoldás során. A társadalmi innováció kezdő lépése emiatt lehet már az is, ha az állampolgárságra nevelés, mint igény megjelenik a közösségben. A kutatás szerint a formális, informális és nem formális állampolgárságra nevelés közül ez utóbbi alkalmas a leginkább arra, hogy az állampolgári kompetenciát fejlessze és az állampolgári identitást erősítse. Az állampolgárságra nevelésben lehet cél ez a közösségi tudat, az ismeretanyag elsajátítása, valamint ennek a tudásnak az alkalmazása egyéni vagy közösségi érdekből. A cél ilyen meghatározása leginkább arra jó, hogy kiderüljön, hol tart a társadalmi megújulás folyamata. A kutatás olyan modellt kívánt az állampolgárságra neveléssel foglalkozó szakemberek számára nyújtani, amely egyszerűen adaptálható és képes a szükségletre adott válaszként hatékonyan támogatni az aktív állampolgárság kibontakozását, és ezen keresztül a társadalmi innovációt.
Wearable Technology in Mobility and Falls Health Care: Finding Consensus on Their Clinical Utility and Identifying a Roadmap to Actual Use
Authors: Ambrens Meghan , Delbaere Kim , Butcher Ken , Close Jacqueline , Gonski Peter , Kohler Friedbert , Lovell Nigel H. , Treacy Daniel , van Schooten Kimberley S. 
Published: January 2025

Background:
Despite the promise wearable technology offers through detailed insight into mobility and fall risk, timely identification of high risk, assessment of risk severity, evaluation of clinical interventions, and potential to redefine the assessment of behaviours which influence health, they are not routinely used in clinical practice.

Objective:
Establish consensus on how wearable technology can be applied to support clinical care for people aged 50 and over experiencing changes to mobility and/or who are at increased risk of falling.

Methods:
A Delphi study was conducted among 17 hospital-based health professionals. Over three rounds, experts were asked about fall prevention, mobility assessment, the potential role of wearable sensors, and clinical considerations for implementing wearable technology into practice. Consensus was defined as 75% agreement. Data were analysed using qualitative and quantitative methods.

Results:
Experts found that wearable technology has short and long-term clinical utility, data should be shared with general practitioners to improve long-term health outcomes, and devices would need to fit all individuals with a preference for wrist or pendant-worn locations. Technological literacy was not a perceived barrier. However, cost and data accuracy were important for successful implementation.

Conclusion:
This study provides a group consensus statement and guidance on the clinical implementation of wearable technology to support care for people aged 50 and over experiencing changes to mobility and/or who are at increased risk of falling. Health professionals are receptive to using wearable technologies to advance fall risk and mobility assessment and believe wearable technology has a role in clinical practice.
Education as Performative Contradiction: Limits (And Possibilities) of Subjectification in the Anthropocene
Authors: Pocius Audrius 
Published: January 2025

An environmentally reoriented educational policy is oftentimes regarded as the premier locus for a societal response to the climate crisis. As observed by Gough (2021), a general belief shared among both policy makers and academics is a consensus that education needs to be perceived less as an instrument for securing sociocultural reproduction and transmission of existing knowledge and more as a catalyst for social and cultural change. The aim of this article is a critical investigation into possibilities and obstacles for education to achieve such change, given the condition of ‘ontological insecurity’ (Hamilton, 2017) that the Anthropocene implies. It is divided into three parts: 1) following Chakrabarty, I identify the politico-aesthetic challenges posed by anthropogenic climate change and formulate their relevance as an educational ordeal; 2) I enquire about the challenges and possibilities for environmental education to foster societal change and conclude that, while a general policy change toward sustainable education may be insufficient, education remains a premier site where negotiations could take place between the deep-seated beliefs about subjectivity and an open anticipation of unforeseen modes of agency; 3) after providing a comparative analysis of classical humanist Bildung and post-humanist accounts of subjectification in education, I conclude that these approaches constitute a performative contradiction, which allows the experiential challenges of the Anthropocene to be approached in terms of a reimagined aesthetic education thematized as a critique of (human) capacity.
Miklós Zrínyi in Venice: Trading advantages, cultural interests and political intrigue in the mid-17th century
Authors: Nicolosi Simona 
Published: January 2025

AbstractIn the mid-17th century, Venice became the stage on which the Zrínyi family played out its many and multifaceted political, commercial and cultural interests. The elder brother Miklós (1620–1664), besides being one of the most well-regarded poets of 17th-century Hungarian literature, was also a politician (serving as the Ban of Croatia) and a skilled businessman. He spent his entire life fighting against the Turkish Ottoman invaders, while also attempting to reign in the uneasy alliance with the Habsburgs. The focus of this paper is to explore the visits Miklós made to Venice, together with his younger brother Péter (1621–1671) and his sister-in-law Katarina Frankopan (1625–1673), to look after their commercial interests, as well as to purchase Italian editions for their well-stocked library and find a publisher for their own translations and, last but not least, to forge diplomatic ties with the French ambassador Piero Bonsi (1631–1703), in a bid to defend the independence of Hungary, even if this meant upsetting the traditional European alliances.
Gaming disorder: Neural mechanisms and ongoing debates
Authors: Zheng Yong-Bo , Zhang Sheng-Nan , Tang Hua-Da , Wang San-Wang , Lin Xiao , Bao Yan-Ping , Wang Yu-Mei , Griffiths Mark D. , Sun Jie , Han Ying , Lu Lin 
Published: January 2025

AbstractBackground and aimsThe inclusion of gaming disorder as a new diagnosis in the 11th revision of the International Statistical Classification of Diseases (ICD-11) has caused ongoing debate. This review aimed to summarise the potential neural mechanisms of gaming disorder and provide additional evidence for this debate.MethodsWe conducted a comprehensive literature review of gaming disorder, focusing on studies that investigated its clinical characteristics and neurobiological mechanisms. Based on this evidence, we further discuss gaming disorder as a psychiatric disorder.ResultsThe present review demonstrated that the brain regions involved in gaming disorder are related to executive functioning (e.g., anterior cingulate cortex and dorsolateral prefrontal cortex), reward systems (e.g., striatum and orbitofrontal cortex), and emotional regulation (e.g., insula and amygdala). Despite the inclusion of gaming disorder in the ICD-11, the debate remains on the benefits and harms of classifying it as a mental health disorder. Opponents argue that the current manifestations that support gaming disorder as a psychiatric disorder remain inadequate, it could cause moral panic among healthy gamers, and that the label of gaming disorder is stigmatising.DiscussionEvidence suggests that gaming disorder shares similar neurobiological alterations with other types of behavioural and substance-related addictions, which further supports gaming disorder as a behavioural addiction. Ongoing debates on whether gaming disorder is a psychiatric disorder push for further exploring the nature of gaming disorder and resolving this dilemma in the field.
Stabilitas fisik dan uji iritasi produk peel-off mask dari ekstrak H. scabra, A. marina, dan bittern
Authors: Ridyawati Ika Wahyu , Asih Eka Nurrahema Ning 
Published: January 2025

Peel-off mask adalah jenis kosmetik yang banyak digunakan untuk mengatasi kulit wajah kering. Penggunaan produk ini dapat melembapkan dan memberikan efek relaksasi karena kaya kandungan mineral bagi kulit. Bahan hayati laut kaya mineral yang berpotensi sebagai bahan peel-off mask adalah ekstrak Holothuroidea scabra, Avicennia marina dan bittern. Tujuan dari penelitian ini adalah menentukan formula produk peel-off mask terbaik dari ekstrak H. scabra, A. marina dan bittern berdasarkan stabilitas fisik dan uji iritasi. Uji meliputi rendemen ekstrak, formulasi peel-off mask, stabilitas fisik (organoleptik, cyling test, uji pH dan uji waktu mengering) dan uji iritasi (eritema, panas dan gatal-gatal). Formula yang digunakan pada penelitian ini yaitu bittern (mL)+H. scabra (mg)+A. marina (mg) dengan F0 (kontrol), F1 (33,33+33,33+33,33), F2 (50+25+25), F3 (25+50+25), dan F4 (25+25+50). Hasil penelitian menunjukkan bahwa stabilitas fisik produk terbaik terdapat pada F2 (bittern 50 mL, ekstrak H. scabra 25 g, dan A. marina 25 g). Formula ini aman digunakan di kulit wajah karena 30 panelis tidak mengalami iritasi (eritema, panas dan gatal-gatal) dengan pH produk yaitu 5,52 sesuai dengan nilai kulit normal pada wajah.
“Symbaloo Lesson Plans” como herramienta de enseñanza en la educación en línea en Diseño de Interiores
Authors: Zhindón-Duarte Jonnathan Andrés 
Published: January 2025

Actualmente son desaprovechadas las ventajas de la tecnología y es escasa su aplicación en los aspectos pedagógicos; sin embargo, debido a la situación actual en la cual el mundo enfrenta la pandemia Covid-19, la educación se ha vuelto cambiante y tiene necesidades diferentes. Los centros de instrucción han visto la necesidad de volcarse a la interactividad y los entornos colaborativos digitales. En el presente estudio se actualizan conceptos, datos y resultados útiles sobre el uso de la herramienta Symbaloo Lesson Plans, que permite la enseñanza-aprendizaje en estos tiempos de educación en línea, mediante el uso de recursos digitales. Se consideró a los estudiantes de la Carrera de Diseño de Interiores de la Universidad de Cuenca, del ciclo marzo-septiembre 2020 en la materia Vivienda Nómada, quienes afrontaron el cambio de la educación presencial a la virtual. Se analizó el uso de las TIC en la educación, la aplicación, la satisfacción y beneficio en el aprendizaje; esto se logró con la realización de estudios cuantitativos. La investigación concluyó que la aplicación de las nuevas tecnologías de la comunicación aportó en el aprendizaje de los estudiantes, además los estímulos se activaron y aceleró el proceso de conocimiento mediante un entorno adecuado para el estudiante: se demostró que los estudiantes tienen el interés de ser copartícipes de este nuevo método de aprendizaje personalizado, además con la implementación de este estudio se puede impulsar la integración, adaptación o mejoramiento de las TIC en otras asignaturas de la carrera en estos tiempos de educación en línea.
`Socio-Demographic Association with Nutritional Status in Children Aged 8-9 Years Old in Surabaya: Focusing on HAZ Status in Path Analysis
Authors: Ardianah Eva , Indriani Diah , Soenarnatalina Melaniani , Widjaja Nur Aisiyah , Santoso Febrina Mustika 
Published: January 2025

Background: Child health, growth, and nutrition are influenced by socioeconomic, cultural, demographic, climatic, nutrition, physical, hygiene, sanitation, medical, and environmental factors. LAZ/HAZ was used to assess the presence of 'stunting' in the population, which indicates chronic malnutrition. Objectives: to investigate the socio-demographics, lifestyle (sleep duration, screen time) and HAZ status of children in 2nd and 3rd grade of elementary school, and the correlation of socio-demographics with the anthropometric parameters. Methods: An observational study with a cross-sectional design was conducted during October – December 2022 in Surabaya, involving healthy children aged 9-10 years old who were in 2nd and 3rd grade of elementary school. Results: BMI-for-age z-score was higher in males than females. Overweight/obesity were prevalent in males (15.16% vs. 10.67%), and underweight and severely underweight were prevalent in females (12.27% vs. 14.23%). The prevalence of stunted/severely stunted was 12.39%. HAZ and WAZ were correlated positively with parental height. The number of children in the household had a negative, weak correlation with HAZ. The maternal education showed that the prevalence of maximal elementary school graduation was higher in stunted children than in normal children (29.27% vs. 18.14%, p=0.043). Fathers' salaries below minimum regional wage were more prevalent among stunted and severely stunted (81.71% and 75%, respectively) than normal subjects (60%), p=0.007. Conclusion: Socio-demographic factors affecting the prevalence of stunting in children were the father's salary and maternal education. Meanwhile, factors associated with HAZ were parental height and number of children in the household. The effect of socio-demography on HAZ was mediated by parental education, which stimulates household economics and has a further effect on food intake and child anthropometrics.
MAIN NEONATAL HARMS ASSOCIATED WITH CESAREAN: A INTEGRATIVE REVIEW
Authors: Pablo Emanoel Damasceno Alves da Silva  , Ian Mendonça Dantas de Matos  , Samyra Maria Fontes de Sousa  , João Gabriel Jacinto  , Fabiana de Andrade Bringel  
Published: January 2025

Introduction :The Cesarean Section is a medical procedure widely utilized. Originally, it was conceived as a last-resort intervention to save the life of the mother or fetus in critical situations. Over the years, however, it has become an increasingly common option, often favored by pregnant individuals given the perception of safety at the final stages of pregnancy. Factors such as maternal comorbidities, financial incentives and the lack of birth plans during prenatal care contribute significantly to the increase of CS rates. Nonetheless, this growing preference is not without its adverse impacts. Goals: To analyze the main neonatal harms associated with Cesarean Section.Methodology: This study comprehends an integrative review of the literature, utilizing the PubMed/Medline database and articles repositories (PUC-Goiás and E-Acadêmia). The research was conducted using the boolean operator “AND” and the keywords: “Cesarean Section”, “Infant”, “Newborn” and “Neonatology”. Five articles were selected for full reading, according to inclusion and exclusion criteria – articles published over the past six years and related to the subject, excluding incomplete or duplicated articles.Results: Studies indicate that Cesarean Section is associated with neonatal harms, such as respiratory problems, increased risk of infections, immunological disorders and possible impacts on neurological development. Vaginal delivery promotes the perinatal stress that stimulates pulmonary maturation through increased production of catecholamines and cortisol, processes absent in CS. Babies born by Cesarean Section are colonized by hospital bacteria, impairing immunological development. The correlation between the type of delivery and neurological disorders is yet inconclusive. Beyond that, CS is related with reduced skin-to-skin contact and reduced initial breastfeeding.Discussion: Despite necessary in several cases, CS presents substantial risks to the newborn. The respiratory complications result from the lack of physiological stress of vaginal delivery, which is essential to extrauterine respiratory adaptation. Bacterial colonization in CS can impair the immune system, increasing vulnerability to infections and allergies. Reduced skin-to-skin contact and lack of early breastfeeding can also impact the bond between mother-baby and neonatal health, increasing the need for neonatal interventions. Conclusion: Based on the information analyzed, it is evident that the Cesarean Section, despite being a common practice, is associated with an increase in risk of neonatal complications. The sanitary interventions must be focused on raising awareness of the risks involved and promoting policies that ensure informed choice and appropriate use of this practice.
KEYWORDS: Cesarean Section; Newborn; Infant; Neonatology;