bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantum interference on the non-commutative plane and the quantum-to-classical transition
Authors: Pittaway I B , Scholtz F G 
Published: March 2023

Abstract
We explore a possible link between the structure of space at short length scales and the emergence of classical phenomena at macroscopic scales. To this end we adopt the paradigm of non-commutative space at short length scales and explicitly compute the outcomes of a double slit experiment and a von Neumann measurement in the non-commutative plane. A very consistent picture of a continuous quantum-to-classical transition emerges. The mechanism driving this transition is standard decoherence, which arises quite naturally from the tensor product structure of the non-commutative quantum Hilbert space. The double slit calculation enables us to establish a lower bound on the non-commutative parameter for this transition to become effective at particle numbers of the order of Avogadro’s number. Similarly, the result of the von Neumann measurement establishes a criterion involving the non-commutative parameter, apparatus size and coupling between system and apparatus for classicality to emerge.
Low-pressure-RF plasma modification of UiO-66 and its application in methylene blue adsorption
Authors: ZHOU Tian , YANG Douhao , WANG Yijun , CHENG Jiushan , CHEN Qiang , LIU Bowen , LIU Zhongwei 
Published: March 2023

Abstract
Defect engineering of metal-organic frameworks has attracted increasing attention in recent years for potential applications in gas storage and catalysis. In this study, defective UiO-66 is obtained by Ar and H2 plasma treatments. Compared with the pristine UiO-66, a new aperture with a size of ∼4 nm appears for a sample with the plasma modification, indicating the formation of mesopores within UiO-66 framework. Characterization results demonstrate that the pore volume, surface area and the number of Lewis and Brönsted acid sites can be easily tuned by varying the discharge parameters. The adsorption performance of UiO-66 is evaluated for the adsorption of methyl blue. In comparison to the pristine UiO-66 and the sample with H2 plasma treatment, the Ar plasma modified sample shows excellent adsorption activity due to the suitable pore size and volume. Equilibrium adsorption capacity as high as 40.6 mg·g−1 is achieved for the UiO-66 (Ar) sample.
PROSE: phenotype-specific network signatures from individual proteomic samples
Authors: Wong Bertrand Jern Han , Kong Weijia , Peng Hui , Goh Wilson Wen Bin 
Published: March 2023

AbstractProteomic studies characterize the protein composition of complex biological samples. Despite recent advancements in mass spectrometry instrumentation and computational tools, low proteome coverage and interpretability remains a challenge. To address this, we developed Proteome Support Vector Enrichment (PROSE), a fast, scalable and lightweight pipeline for scoring proteins based on orthogonal gene co-expression network matrices. PROSE utilizes simple protein lists as input, generating a standard enrichment score for all proteins, including undetected ones. In our benchmark with 7 other candidate prioritization techniques, PROSE shows high accuracy in missing protein prediction, with scores correlating strongly to corresponding gene expression data. As a further proof-of-concept, we applied PROSE to a reanalysis of the Cancer Cell Line Encyclopedia proteomics dataset, where it captures key phenotypic features, including gene dependency. We lastly demonstrated its applicability on a breast cancer clinical dataset, showing clustering by annotated molecular subtype and identification of putative drivers of triple-negative breast cancer. PROSE is available as a user-friendly Python module from https://github.com/bwbio/PROSE.
AMHMDA: attention aware multi-view similarity networks and hypergraph learning for miRNA–disease associations identification
Authors: Ning Qiao , Zhao Yaomiao , Gao Jun , Chen Chen , Li Xiang , Li Tingting , Yin Minghao 
Published: March 2023

AbstractIn recent years, many experiments have proved that microRNAs (miRNAs) play a variety of important regulatory roles in cells, and their abnormal expression can lead to the emergence of specific diseases. Therefore, it is greatly valuable to do research on the association between miRNAs and diseases, which can effectively help prevent and treat miRNA-related diseases. At present, effective computational methods still need to be developed to better identify potential miRNA–disease associations. Inspired by graph convolutional networks, in this study, we propose a new method based on Attention aware Multi-view similarity networks and Hypergraph learning for MiRNA-Disease Associations identification (AMHMDA). First, we construct multiple similarity networks for miRNAs and diseases, and exploit the graph convolutional networks fusion attention mechanism to obtain the important information from different views. Then, in order to obtain high-quality links and richer nodes information, we introduce a kind of virtual nodes called hypernodes to construct heterogeneous hypergraph of miRNAs and diseases. Finally, we employ the attention mechanism to fuse the outputs of graph convolutional networks, predicting miRNA–disease associations. To verify the effectiveness of this method, we carry out a series of experiments on the Human MicroRNA Disease Database (HMDD v3.2). The experimental results show that AMHMDA has good performance compared with other methods. In addition, the case study results also fully demonstrate the reliable predictive performance of AMHMDA.
On Conditional Edge-Fault-Tolerant Strong Menger Edge Connectivity Of Folded Hypercubes
Authors: Zhao Shijie , Li Pingshan 
Published: March 2023

Abstract
Edge connectivity is an important parameter for the reliability of the inter-connection network. A graph $G$ is strong Menger edge-connected ($SM$-$\lambda $ for short) if there exist min$\{\deg _{G}(u),\deg _{G}(v)\}$ edge-disjoint paths between any pair of vertices $u$ and $v$ of $G$. The conditional edge-fault-tolerance strong Menger edge connectivity of $G$, denoted by $sm_{\lambda }^{r}(G)$, is the maximum integer $m$ such that $G-F$ remains $SM$-$\lambda $ for any edge set $F$ with $|F|\leq m$ and $\delta (G-F)\geq r$, where $\delta (G-F)\geq r$ is the minimum degree of $G-F$. Most of the previous papers discussed $sm_{\lambda }^{r}(G)$ in the case of $r\leq 2$. In this paper, we show that $sm_{\lambda }^{r}(FQ_{n})=2^{r}(n-r+1)-(n+1)$ for $1\leq r\leq n-2$, where $n\geq 4$.
On the Removal of Asylum Seekers to Third Countries and the Scope of theEU–Turkey Readmission Agreement
Authors: Arıner Hakkı Onur , Kader Yiğit 
Published: March 2023

Abstract
The inclusion of asylum seekers within the scope of European Union (EU) readmission agreements signed with third countries remains contentious, especially considering that these agreements are instruments for removing irregular migrants to countries of origin or transit and do not regulate the responsibility for assessing asylum claims. Yet, the expulsion of asylum seekers from the EU to third countries is realized through a procedure whereby Member States are allowed the possibility of labelling third countries ‘safe’ according to criteria set out in EU law. The applications of asylum seekers arriving from safe third countries to the jurisdiction of the EU are deemed ‘inadmissible’, thus absolving Member States from assessing the applications on merit and enabling States to include asylum seekers within the scope of readmission agreements as irregular migrants. This article contends that the unique features of the EU–Turkey Readmission Agreement do not allow this practice in light of the main principles of international law, even assuming that Turkey can be labelled a ‘safe third country’. These features include treaty provisions obligating the sending State to make every effort to remove persons to their countries of origin, as well as Turkey’s explicitly declared position during the signing of the Agreement, which interprets the scope of the Agreement as not including asylum seekers. However, readmission of asylum seekers has taken place between the EU and Turkey through the EU–Turkey Statement of 18 March 2016 on the legal basis of the bilateral Greece–Turkey Readmission Agreement. It is argued that the EU’s attempts to institute the EU–Turkey Readmission Agreement as the legal basis for readmission of asylum seekers are destined to fail, due to the legal impossibility stemming from the said unique treaty provisions, as well as the absence of any indication from Turkey that it intends to change its initial official position in this regard.
Downregulation of RUNX1-Activated Osteopontin Facilitates Burn Wound Healing by Activating the MAPK Pathways
Authors: Ji Wei , Sun Zhibo , Yang Yanqing , Hu Meng , Zhang Qian , Fu Jie , Chen JunWei , Huang Yan , Cheng Yanyang 
Published: March 2023

Abstract
Burn wounds require intervention to ensure timely progression to reduce morbidity and mortality. The migrative and proliferative capabilities of keratinocytes are impaired in wounds. Matrix metalloproteinases (MMPs) can degrade the extracellular matrix (ECM), allowing epithelial cells to migrate. As reported, osteopontin can regulate cell migration, cell adhesion, and ECM invasion in endothelial and epithelial cells, and its expression is significantly increased in chronic wounds. Therefore, this study investigates the biological functions of osteopontin and its related mechanisms involved in burn wounds. We established cellular and animal models of burn injury. Levels of osteopontin, RUNX1, MMPs, collagen I, CK19, PCNA, and pathway-associated proteins were measured by RT-qPCR, western blotting, and immunofluorescence staining. Cell viability and migration were examined by CCK-8 and wound scratch assays. Histological changes were analyzed by hematoxylin and eosin staining and Masson’s trichrome staining. For in vitro analysis, osteopontin silencing facilitated the growth and migration of HaCaT cells and promoted ECM degradation in HaCaT cells. Mechanistically, RUNX1 bound to osteopontin promoter, and RUNX1 upregulation attenuated the promoting efficacy of osteopontin silencing on cell growth and migration and ECM degradation. Additionally, RUNX1-activated osteopontin inactivated the MAPK signaling pathway. For in vivo analysis, osteopontin depletion facilitated burn wound healing by promoting reepithelialization and ECM degradation. In conclusion, RUNX1 activates the osteopontin expression at the transcriptional level and osteopontin depletion facilitates the recovery of burn wounds by promoting the migration of keratinocytes and reepithelization and ECM degradation by activating the MAPK pathway.
Revisiting the cumulative incidence function with competing risks data
Authors: Zucker David M , Gorfine Malka 
Published: March 2023

AbstractWe consider estimation of the cumulative incidence function (CIF) in the competing risks Cox model. We study three methods. Methods 1 and 2 are existing methods while method 3 is a newly proposed method. Method 3 is constructed so that the sum of the CIF’s across all event types at the last observed event time is guaranteed, assuming no ties, to be equal to 1. The performance of the methods is examined via simulation, and they are illustrated on data from the field of computer code comprehension. The newly proposed method 3 exhibits performance comparable to that of methods 1 and 2 in terms of bias and variance, and better than that of Methods 1 and 2 in terms of confidence interval coverage rates.
10-year survival of pulmonary arterial hypertension associated with connective tissue disease: insights from a multicentre PAH registry
Authors: Chen Xiaoxi , Quan Ruilin , Qian Yuling , Yang Zhenwen , Yu Zaixin , Zhang Caojin , Yang Yuanhua , Zhang Gangcheng , Shen Jieyan , Wang Qian , Gu Qing , Xiong Changming , Jing Xiaoli , Han Huijun , He Jianguo 
Published: March 2023

Abstract

Objectives
To report the 10-year survival rate and prognostic factors of pulmonary arterial hypertension associated with CTD (CTD-PAH) patients, to compare treatment and survival between patients enrolled before and after 2015, and to validate the discrimination of the recommended four-strata model in predicting 10-year survival at follow-up in Chinese CTD-PAH patients.

Methods
This study was derived from a Chinese national multicentre prospective registry study from 2009 to 2019. Medical records were collected at baseline and follow-up, including PAH-targeted therapy and binary therapy (both CTD and PAH-targeted therapy).

Results
A total of 266 CTD-PAH patients were enrolled and the 10-year survival rate was 59.9% (median follow-up time: 4.85 years). Underlying CTD (SSc), baseline 6-min walking distance and SaO2 were independent risk factors for 10-year survival. The proportion of patients receiving PAH-targeted combination therapy increased from 10.1% (2009–2014) to 26.5% (2015–2019) and that of binary therapy increased from 14.8% to 35%. The 1-year survival rate increased from 89.8% (2009–2014) to 93.9%, and the 3-year survival rate increased from 80.1% (2009–2014) to 86.5% (both P &gt; 0.05). The four-strata strategy performed well in predicting 10-year survival at follow-up (C-index = 0.742).

Conclusion
The 10-year survival rate of CTD-PAH patients was reported for the first time. The 10-year prognosis was poor, but there was a tendency for more standardized treatment and better survival in patients enrolled after 2015. The recommended four-strata model at follow-up can effectively predict 10-year survival in CTD-PAH patients.
State Nobility in the Field of International Criminal Justice: Divergent Elites and the Contest to Control Power over Capital
Authors: Christensen Mikkel Jarle 
Published: March 2023

AbstractCriminal law was long considered as the sovereign domain of the state. However, after the end of the Cold War, states created new international criminal courts. These courts are part of a wider field of international criminal justice in which different elites work to develop, support, and critique legal ideas and practices that either complement or challenge the state. Inspired by Pierre Bourdieu’s sociology and based on a multiple correspondence analysis with sixty-four modalities, this article contributes a critical analysis of 365 elite agents active in this field. The analysis shows how different types and volumes of capital structure relations between these elites as well as between the field of international criminal justice and the state. Because these relations can turn state nobility against its national origins, international criminal justice poses a potential challenge to the state’s social fabric which goes beyond legal and political controversies: International criminal justice is emblematic of a competition over the value of and control over capital which plays out at the borders between the national and the international. This contest underlines that the state does necessarily control power over state capital and that, when its elites no longer reproduce its meta-capital, the state loses the semblance of being a unified actor on the world stage. Whereas the intensity of this contest over capital might be particular to the field of international criminal justice, similar battles of control are likely to affect the relations between the state and other globalized fields of law, justice, and politics.
Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat
Authors: Conolly Rory B , Schroeter Jeffry , Kimbell Julia S , Clewell Harvey , Andersen Melvin E , Gentry P Robinan 
Published: March 2023

Abstract
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma (SCC). This outcome is well-characterized: including dose-response and time course data for SCC, mechanistic endpoints, and nasal dosimetry. Conolly et al. (Toxicol. Sci. 75, 432–447, 2003) used these resources to develop a biologically based dose-response (BBDR) model for SCC in F344 rats. This model, scaled up to humans, has informed dose-response conclusions reached by several international regulatory agencies. However, USEPA concluded that uncertainties precluded its use for cancer risk assessment. Here, we describe an updated BBDR model that addresses uncertainties through refined dosimetry modeling, revised analysis of labeling index data, and an extended dataset where both inhaled (exogenous) and endogenous formaldehyde (exogF, endoF) form DNA adducts. Further, since Conolly et al. (ibid) was published, it has become clear that, when controls from all F344 inhalation bioassays are considered, accounting for over 4000 rats, at most one nasal SCC occurred. This low spontaneous incidence constrains possible contribution of endoF to the formation of nasal SCC via DNA reactivity. Further, since both exogF and endoF form DNA adducts, this constraint also applies to exogF. The revised BBDR model therefore drives SCC formation through the cytotoxicity of high concentration exogF. An option for direct mutagenicity associated with DNA adducts is retained to allow estimation of an upper bound on adduct mutagenicity consistent with the lack of a spontaneous SCC incidence. These updates represent an iterative refinement of the 2003 model, incorporating new data and insights to reduce identified model uncertainties.
Challenges and prospects of managing non-acute medical conditions among pastoral populations in sub-Saharan Africa
Authors: Ekeria Emmanuel , Opawoye Adefolarin , Abubakar Muhammad S , Iliyasu Garba , Habib Abdulrazaq G 
Published: March 2023

ABSTRACT
In Africa, pastoral populations face several underrecognized health issues. The livelihoods of pastoralists revolve around possession of livestock and they are constantly moving in search of water and pasturage. They are predisposed to chronic zoonotic infections but may also suffer from non-acute non-zoonotic cosmopolitan infectious and non-infectious chronic medical conditions. Given their migratory lifestyle, livelihood, geographic inaccessibility, communication barriers, illiteracy and poverty, it is challenging for pastoralists to access lengthy inpatient clinical care and long-term periodic follow-up that may be required to achieve control or cure of subacute, chronic or lifelong diseases. The challenges and management modalities of complicated subacute bacterial endocarditis requiring critical clinical considerations, long-term medical and surgical interventions in a stateless Arab camel herder are described to highlight the plight of pastoralists. Innovative clinical and public health strategies are suggested to authorities and healthcare institutions to improve access to care for non-acute diseases among them.
High and dry: integrative taxonomy of the Andean spider genus Nerudia (Araneae: Pholcidae)
Authors: Huber Bernhard A , Meng Guanliang , Král Jiří , Ávila Herrera Ivalú M , Izquierdo Matias A , Carvalho Leonardo S 
Published: March 2023

Abstract
Ninetinae are a group of poorly known spiders that do not fit the image of ‘daddy long-legs spiders’ (Pholcidae), the family to which they belong. They are mostly short-legged, tiny and live in arid environments. The previously monotypic Andean genus Nerudia exemplifies our poor knowledge of Ninetinae: only seven adult specimens from two localities in Chile and Argentina have been reported in the literature. We found representatives of Nerudia at 24 of 52 localities visited in 2019, mostly under rocks in arid habitats, up to 4450 m a.s.l., the highest known record for Pholcidae. With now more than 400 adult specimens, we revise the genus, describing ten new species based on morphology (including SEM) and COI barcodes. We present the first karyotype data for Nerudia and for its putative sister-genus Gertschiola. These two southern South American genera share a X1X2X3Y sex chromosome system. We model the distribution of Nerudia, showing that the genus is expected to occur in the Atacama biogeographic province (no record so far) and that its environmental niche is phylogenetically conserved. This is the first comprehensive revision of any Ninetinae genus. It suggests that focused collecting may uncover a considerable diversity of these enigmatic spiders.
Motor Vehicle Crash Risk among Adults Undergoing General Surgery: A Retrospective Case-crossover Study
Authors: Gaulton Timothy G. , Pfeiffer Melissa R. , Metzger Kristina B. , Curry Allison E. , Neuman Mark D. 
Published: March 2023

Background
Surgery causes transient impairment in cognition and function, which may impact driving safety. The authors hypothesized that the risk of a motor vehicle crash would increase after compared to before surgery.

Methods
The authors performed a nested case-crossover study within population-based observational data from the New Jersey Safety Health Outcomes Data Warehouse. The study included adults 18 yr or older with a valid driver’s license who underwent general surgery in an acute care hospital in New Jersey between January 1, 2016, and November 30, 2017, and were discharged home. Individuals served as their own controls within a presurgery interval (56 days to 28 days before surgery) and postsurgery interval (discharge through 28 days after surgery). General surgery was defined by Common Procedural Terminology Codes. The primary outcome was a police-reported motor vehicle crash.

Results
In a cohort of 70,722 drivers, the number of crashes after surgery was 263 (0.37%) compared to 279 (0.39%) before surgery. Surgery was not associated with a change in crash incidence greater than 28 days using a case-crossover design (adjusted incidence rate ratio, 0.92; 95% CI, 0.78 to 1.09; P = 0.340). Statistical interaction was present for sex and hospital length of stay. Younger versus older adults (adjusted risk ratio, 1.87; 95% CI, 1.10 to 3.18; P = 0.021) and non-Hispanic Black individuals (adjusted risk ratio, 1.96; 95% CI, 1.33 to 2.88; P = 0.001) and Hispanic individuals (adjusted risk ratio, 1.38; 95% CI, 1.00 to 1.91; P = 0.047) versus non-Hispanic White individuals had a greater risk of a crash after surgery.

Conclusions
Using population-based crash and hospital discharge data, the incidence of motor vehicle crashes over a 28-day period did not change on average before compared to after surgery. The authors provide data on crash risk after surgery and highlight specific populations at risk.

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