bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, risk factors, and mortality of COPD in young people in the USA: results from a population-based retrospective cohort
Authors: Wang Zihui , Li Yun , Lin Junfeng , Huang Jinhai , Zhang Qing , Wang Fengyan , Tan Lunfang , Liu Shuyi , Gao Yuan , Peng Shiyin , Fang Heai , Weng Yuting , Li Shiyin , Gao Yi , Zhong Nanshan , Zheng Jinping 
Published: July 2023

BackgroundChronic obstructive pulmonary disease (COPD) has been considered a disease of the elderly, but it could also occur in young people aged 20–50 years. However, the characteristics and prognosis of COPD in such young people remain unclear.MethodsOur retrospective cohort study was based on the National Health and Nutrition Examination Survey (NHANES). Participants who 20–50 years old at baseline and completed the pulmonary function test were enrolled in our study cohort. These participants were followed up to 31 December 2019. The sample weight and Taylor Linearization Procedures were adapted to make representative estimations of prevalence and baseline characteristics. The weighted logistic regression model was used to assess the risk factors. The propensity score method and Cox proportional hazard models were applied to calculate the risk of mortality.ResultsThe weighted prevalence of COPD in young people in the USA was 1.64% and it increased with age, with a higher prevalence in males than females (2.59% vs 0.72%, p<0.001). The proportion of Global Initiative for COPD 1–2 was 96.7%. Males (OR=4.56, 95% CI: 2.74 to 7.61), non-Hispanic black (OR=2.77; 95% CI: 1.14 to 6.75), non-Hispanic white (OR=4.93; 95% CI: 2.16 to 11.28) and smoking (current smoking, OR=2.36; 95% CI: 1.40 to 3.98; ever smoking, OR=1.92; 95% CI: 1.05 to 3.51; passive smoking, OR=2.12; 95% CI: 1.41 to 3.20) were shown to be independent risk factors for COPD in young people. Compared with those matched by sex, age and race, the young people with COPD had a higher risk of all-cause death (HR=3.314, p<0.001).ConclusionCOPD in young people has a low prevalence in the USA and its independent risk factors included male, race (non-Hispanic black and non-Hispanic white) and smoking. Young COPD has a higher risk of all-cause mortality than the matched non-COPD.
Bisoprolol versus celiprolol on dynamic hyperinflation, cardiopulmonary exercise and domiciliary safety in COPD: a single-centre, randomised, crossover study
Authors: Anderson William , Short Philip , Ross Rose , Lipworth Brian J 
Published: July 2023

BackgroundChronic obstructive pulmonary disease (COPD) is frequently associated with cardiovascular disease. The utility of beta-blockers for treating patients with COPD may be beneficial, but their safety remains uncertain, including worsening of dynamic hyperinflation (DH) during exercise. We hypothesised that among cardioselective beta-blockers celiprolol, due to its partial beta-2 agonist activity, may be safer than bisoprolol on exercise DH.MethodsWe measured isotime inspiratory capacity (IC) during cycle endurance testing in eleven moderate-severe COPD subjects, alongside other non-invasive cardiopulmonary exercise, bioreactance cardiac output, pulmonary function, biomarkers and daily domiciliary measures. Participants received titrated doses of either bisoprolol (maximim 5 mg) or celiprolol (maximum 400 mg) in randomised crossover fashion, each over 4 weeks.ResultsClinically relevant DH occurred between resting and exercise isotime IC but showed no significant difference with either beta-blocker compared with post-run-in pooled baseline or between treatments. There were no other significant differences observed for remaining exercise ventilatory; non-invasive cardiac output; resting pulmonary function; beta-2 receptor and cardiac biomarkers; domiciliary pulmonary function, oxygen saturation and symptom outcomes, either between treatments or compared with baseline. No significant adverse effects occurred.ConclusionsSignificant DH in moderate-severe COPD subjects was no different between bisoprolol or celiprolol or versus baseline. A broad spectrum of other non-invasive cardiopulmonary and domiciliary safety outcomes was equally reassuring. Bronchoprotection with a concomitant long-acting muscarinic antagonist might be an important safety measure in this context.Trial registration numberNCT02380053.
Definition of gravitational local spatial densities for spin-0 and spin-1/2 systems
Authors: Panteleeva J. Yu. , Epelbaum E. , Gegelia J. , Meißner U. -G. 
Published: July 2023

AbstractWe work out details of defining the spatial densities corresponding to the gravitational form factors of spin-0 and spin-1/2 systems using spherically symmetric sharply localized wave packets. The expressions for the spatial densities are provided in the frames with both zero and non-zero expectation values of the momentum operator.
Spatial distribution of solar PV deployment: an application of the region-based convolutional neural network
Authors: Kim Serena Y. , Ganesan Koushik , Soderman Crystal , O’Rourke Raven 
Published: July 2023

AbstractSolar photovoltaic (PV) deployment plays a crucial role in the transition to renewable energy. However, comprehensive models that can effectively explain the variations in solar PV deployment are lacking. This study aims to address this gap by introducing two innovative models: (i) a computer vision model that can estimate spatial distribution of solar PV deployment across neighborhoods using satellite images and (ii) a machine learning (ML) model predicting such distribution based on 43 factors. Our computer vision model using Faster Regions with Convolutional Neural Network (Faster RCNN) achieved a mean Average Precision (mAP) of 81% for identifying solar panels and 95% for identifying roofs. Using this model, we analyzed 652,795 satellite images from Colorado, USA, and found that approximately 7% of households in Colorado have rooftop PV systems, while solar panels cover around 2.5% of roof areas in the state as of early 2021. Of our 16 predictive models, the XGBoost models performed the best, explaining approximately 70% of the variance in rooftop solar deployment. We also found that the share of Democratic party votes, hail and strong wind risks, median home value, the percentage of renters, and solar PV permitting timelines are the key predictors of rooftop solar deployment in Colorado. This study provides insights for business and policy decision making to support more efficient and equitable grid infrastructure investment and distributed energy resource management.
Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer
Authors: Hermida-Prado Francisco , Xie Yingtian , Sherman Shira , Nagy Zsuzsanna , Russo Douglas , Akhshi Tara , Chu Zhengtao , Feit Avery , Campisi Marco , Chen Minyue , Nardone Agostina , Guarducci Cristina , Lim Klothilda , Font-Tello Alba , Lee Irene , García-Pedrero Juana , Cañadas Israel , Agudo Judith , Huang Ying , Sella Tal , Jin Qingchun , Tayob Nabihah , Mittendorf Elizabeth A. , Tolaney Sara M. , Qiu Xintao , Long Henry , Symmans William F. , Lin Jia-Ren , Santagata Sandro , Bedrosian Isabelle , Yardley Denise A. , Mayer Ingrid A. , Richardson Edward T. , Oliveira Giacomo , Wu Catherine J. , Schuster Eugene F. , Dowsett Mitch , Welm Alana L. , Barbie David , Metzger Otto , Jeselsohn Rinath 
Published: July 2023

Abstract

Immunotherapies have yet to demonstrate significant efficacy in the treatment of hormone receptor–positive (HR+) breast cancer. Given that endocrine therapy (ET) is the primary approach for treating HR+ breast cancer, we investigated the effects of ET on the tumor immune microenvironment (TME) in HR+ breast cancer. Spatial proteomics of primary HR+ breast cancer samples obtained at baseline and after ET from patients enrolled in a neoadjuvant clinical trial (NCT02764541) indicated that ET upregulated β2-microglobulin and influenced the TME in a manner that promotes enhanced immunogenicity. To gain a deeper understanding of the underlying mechanisms, the intrinsic effects of ET on cancer cells were explored, which revealed that ET plays a crucial role in facilitating the chromatin binding of RelA, a key component of the NF-κB complex. Consequently, heightened NF-κB signaling enhanced the response to interferon-gamma, leading to the upregulation of β2-microglobulin and other antigen presentation-related genes. Further, modulation of NF-κB signaling using a SMAC mimetic in conjunction with ET augmented T-cell migration and enhanced MHC-I-specific T-cell–mediated cytotoxicity. Remarkably, the combination of ET and SMAC mimetics, which also blocks prosurvival effects of NF-κB signaling through the degradation of inhibitors of apoptosis proteins, elicited tumor regression through cell autonomous mechanisms, providing additional support for their combined use in HR+ breast cancer.

Significance:
Adding SMAC mimetics to endocrine therapy enhances tumor regression in a cell autonomous manner while increasing tumor immunogenicity, indicating that this combination could be an effective treatment for HR+ patients with breast cancer.
Risk of Colorectal Cancer and Colorectal Cancer Mortality Beginning One Year after a Negative Fecal Occult Blood Test, among Screen-Eligible 76- to 85-Year-Olds
Authors: Dalmat Ronit R. , Ziebell Rebecca A. , Kamineni Aruna , Phipps Amanda I. , Weiss Noel S. , Breslau Erica S. , Burnett-Hartman Andrea N. , Corley Douglas A. , Doria-Rose V. Paul , Green Beverly B. , Halm Ethan A. , Levin Theodore R. , Schottinger Joanne E. , Chubak Jessica 
Published: July 2023

Abstract

Background:
Colorectal cancer screening is universally recommended for adults ages 45 to 75 years. Noninvasive fecal occult blood tests are effective screening tests recommended by guidelines. However, empirical evidence to inform older adults’ decisions about whether to continue screening is sparse, especially for individuals with prior screening.

Methods:
This study used a retrospective cohort of older adults at three Kaiser Permanente integrated healthcare systems (Northern California, Southern California, Washington) and Parkland Health. Beginning 1 year following a negative stool-based screening test, cumulative risks of colorectal cancer incidence, colorectal cancer mortality (accounting for deaths from other causes), and non-colorectal cancer mortality were estimated.

Results:
Cumulative incidence of colorectal cancer in screen-eligible adults ages 76 to 85 with a negative fecal occult blood test 1 year ago (N = 118,269) was 0.23% [95% confidence interval (CI), 0.20%–0.26%] after 2 years and 1.21% (95% CI, 1.13%–1.30%) after 8 years. Cumulative colorectal cancer mortality was 0.03% (95% CI, 0.02%–0.04%) after 2 years and 0.33% (95% CI, 0.28%–0.39%) after 8 years. Cumulative risk of death from non-colorectal cancer causes was 4.81% (95% CI, 4.68%–4.96%) after 2 years and 28.40% (95% CI, 27.95%–28.85%) after 8 years.

Conclusions:
Among 76- to 85-year-olds with a recent negative stool-based test, cumulative colorectal cancer incidence and mortality estimates were low, especially within 2 years; death from other causes was over 100 times more likely than death from colorectal cancer.

Impact:
These findings of low absolute colorectal cancer risk, and comparatively higher risk of death from other causes, can inform decision-making regarding whether and when to continue colorectal cancer screening beyond age 75 among screen-eligible adults.
HLA-I Evolutionary Divergence Confers Response to PD-1 Blockade plus Chemotherapy in Untreated Advanced Non–Small Cell Lung Cancer
Authors: Jiang Tao , Jin Qiqi , Wang Jiahao , Wu Fengying , Chen Jian , Chen Gongyan , Huang Yunchao , Chen Jianhua , Cheng Ying , Wang QiMing , Pan Yueyin , Zhou Jianying , Shi Jianhua , Xu Xingxiang , Lin LiZhu , Zhang Wei , Zhang Yiping , Liu Yunpeng , Fang Yong , Feng Jifeng , Wang Zhehai , Hu Sheng , Fang Jian , Shu Yongqian , Cui Jiuwei , Hu Yi , Yao Wenxiu , Li Xingya , Lin Xiaoyan , Wang Rui , Wang Yongsheng , Shi Wei , Feng Gaohua , Ni Jun , Mao Beibei , Ren Dandan , Sun Huaibo , Zhang Henghui , Chen Luonan , Zhou Caicun , Ren Shengxiang 
Published: July 2023

Abstract

Purpose:
PD-1 blockade plus chemotherapy has become the new standard of care in patients with untreated advanced non–small cell lung cancer (NSCLC), whereas predictive biomarkers remain undetermined.

Experimental Design:
We integrated clinical, genomic, and survival data of 427 NSCLC patients treated with first-line PD-1 blockade plus chemotherapy or chemotherapy from two phase III trials (CameL and CameL-sq) and investigated the predictive and prognostic value of HLA class I evolutionary divergence (HED).

Results:
High HED could predict significantly improved objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) in those who received PD-1 blockade plus chemotherapy [in the CameL trial, ORR: 81.8% vs. 53.2%; P = 0.032; PFS: hazard ratio (HR), 0.47; P = 0.012; OS: HR, 0.40; P = 0.014; in the CameL-sq trial, ORR: 89.2% vs. 62.3%; P = 0.007; PFS: HR, 0.49; P = 0.005; OS: HR, 0.38; P = 0.002], but not chemotherapy. In multivariate analysis adjusted for PD-L1 expression and tumor mutation burden, high HED was independently associated with markedly better ORR, PFS, and OS in both trials. Moreover, the joint utility of HED and PD-L1 expression showed better performance than either alone in predicting treatment benefit from PD-1 blockade plus chemotherapy. Single-cell RNA sequencing of 58,977 cells collected from 11 patients revealed that tumors with high HED had improved antigen presentation and T cell–mediated antitumor immunity, indicating an inflamed tumor microenvironment phenotype.

Conclusions:
These findings suggest that high HED could portend survival benefit in advanced NSCLC treated with first-line PD-1 blockade plus chemotherapy.
See related commentary by Dimou, p. 4706
Subjugating Subjectivity: Why Wright’s Critical Realism is Not Critical Enough
Authors: Chidgzey Aaron 
Published: July 2023

Abstract
This analysis of N. T. Wright’s epistemological model – labelled critical realism – argues that Wright has lamentably failed the ambitious goal of mediating the two epistemic poles of external ‘objective’ reality and internal ‘subjective’ interpretation. The issues raised by scholars of the so-called ‘critical’ end of the dichotomy have subsequently failed to be considered to any significant degree and, instead, Wright ultimately reverts to an objectivist realism of the sort he decries. He privileges the assumptions on the ‘realism’ end and merely gestures toward the critical. This becomes especially clear in his study of Jesus’ resurrection, where his apologetic and historical discussions demonstrate a reliance upon an assumed objectivist and empiricist methodology.
Spatial Semantics: Tafereel, Einder and El Lissitzky
Authors: Koenderink Jan , van Doorn Andrea 
Published: July 2023

Abstract
In visual awareness the expanse of pictorial space fills a slab of finite depth between a frontal plane and a backdrop at infinity. It paradoxically coexists with the flatness of a picture. The constructivist El Lissitzky (1890–1941) suggested that a formal account would therefore require paradoxical notions such as non-Euclidean geometry and imaginary numbers. Perhaps so, for pictorial and physical spaces have distinct ontological roots so they are incommensurable. Alberti’s perspective discards the third dimension. Depth is a mental quality that cannot be represented. Since the picture plane is flat, ‘depth’ has to be imaginary. Imaginary dimensions capture the ‘enchantment’ of pictorial vision. Pictures and Alberti’s perspective address the disenchanted (flat), objective aspect. Only arcane geometries with imaginary dimensions might possibly account for the phenomenology — as they indeed are found to do. Linguistic terms that refer to such imaginary objects — such as ‘tafereel’ and ‘einder’ in Dutch — are scarce.
Spatiotemporal Evaluation of Satellite-Based Precipitation Products in the Colorado River Basin
Authors: Han Heechan , Abitew Tadesse A. , Park Seonggyu , Green Colleen H. M. , Jeong Jaehak 
Published: July 2023

Abstract
Gridded precipitation products from satellite-based systems provide continuous and seamless data that can overcome the limitations of ground-based precipitation data. Remote sensing (RS) products can provide efficient precipitation data in the desert rangelands and the Rocky Mountains of the western United States, where ground-based rain gauges are sparse. In this study, we evaluated the quality of precipitation estimates from the Tropical Rainfall Measuring Mission (TRMM), Climate Hazards Group Infrared Precipitation with Station (CHIRPS), and Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR) in the Upper Colorado River basin (UCRB) for the period 2000–20. The reliability of daily precipitation data from these products was tested against ground-based observations from the National Oceanic and Atmospheric Administration (NOAA) using two continuous and four categorical statistical evaluation metrics. We investigated the effects of topographical conditions on the quality of precipitation estimates. Results show that all three products have 3–4 mm day−1 differences in daily precipitation rates compared to ground observations. In addition, the difference in monthly precipitation rates was more prominent in the wet season (November–April) than in the dry season (May–October). The margin of errors varied with the type of RS system and by location. A categorical evaluation suggests a moderate ability to detect precipitation occurrence with 50%–60% detection ability. The reliability of precipitation estimates is mainly limited by elevation and different ecoregions and climate features.
Feasibility of dyadic peer support to augment a church-based healthy lifestyle programme
Authors: Conley Cherie , Randolph Schenita , Hardison-Moody Annie , Gonzalez-Guarda Rosa , Fisher Edwin B , Lipkus Isaac 
Published: July 2023

Objective: African Americans in the USA experience a disproportionate burden of chronic disease. Healthy lifestyle promotion programmes can help decrease this disease risk. This study determined the feasibility of using dyadic peer support to augment an existing healthy lifestyle programme in African American churches. Design: A prospective pre-post design was used with 80 participants from three churches in the southeastern USA over an 18-week period. Methods: Participants attended 9 weeks of group nutrition classes followed by 9 weeks of a dyadic peer support programme. Feasibility was measured by recruitment, acceptability, ability to collect peer support data, ability to implement the peer support component and preliminary health outcomes. Descriptive statistics and multilevel models were used to analyse the data. Results: Seventy-eight percent of participants completed group classes and peer support activities. Over 95% of participants would work with a partner again. Lay leaders and educators felt they had the resources and participant support to implement a dyadic peer support intervention. Participants achieved small but significant average increases of 1.1 fruit servings per day ( p = .001) and 1.2 days of physical activity per week ( p = .01) post-intervention. Significant changes in weight (−2.6 pounds, 95% confidence interval [CI] = −4.18, −1.1; p = .001) and vegetable intake (0.681 servings, 95% CI = 0.122, 1.241; p = .017) achieved during the first 9 weeks of the programme were maintained during the second 9 weeks. Conclusion: Dyadic peer support can successfully be used to augment existing healthy lifestyle promotion programmes within African American churches. Studies using control groups are needed to test the effectiveness of dyadic peer support on health outcomes more rigorously.
Whole grain perceptions and consumption attitudes: Results of a survey in Italy
Authors: Zanini Barbara , Simonetto Anna , Marconi Silvia , Marullo Monica , Castellano Maurizio , Gilioli Gianni 
Published: July 2023

Objectives: The consumption of whole grains is widely recognised as healthy and included in several national dietary guidelines. Despite that, the consumption of whole grain products remains sub-optimal. Methods: We developed a questionnaire investigating perceptions of price, taste, positive and negative health effects, sustainability and versatility of whole grains and the consumption frequency of whole grain food products. This questionnaire was administered to a sample of 1,014 individuals in Northern Italy. Results: We observed an overall positive attitude towards whole grain products, especially in relation to positive health effects, versatility and taste, that resulted in strong drivers for whole grain consumption. Age, gender and educational level were identified as influences on whole grain perceptions, especially for taste and positive health effects. Respondents were clustered according to the attitudes they expressed. Conclusion: The characteristics of these clusters could be used to customise future nutritional education programmes.
A rapid umbrella review of the literature surrounding the provision of patient-centred end-of-life care
Authors: Hatzikiriakidis Kostas , Ayton Darshini , Skouteris Helen , Patitsas Luke , Smith Kelsay , Dhulia Anjali , Poon Peter 
Published: July 2023

Background: Patients have reported a broad range of unmet needs in their receipt of clinical care at the end of life. Therefore, enhancing the quality of end-of-life care through patient-centred healthcare interactions is warranted. Aim: The aim of this rapid umbrella review was to synthesise previous literature reviews that have examined: (1) patient preferences for patient-centred end-of-life care; (2) barriers and enablers to patient-centred end-of-life care; (3) interventions designed to enhance patient-centred end-of-life care; and (4) patient-centred models of end-of-life care. Design: A rapid umbrella review was conducted and informed by the Joanna Briggs Institute’s methodological guidance for conducting umbrella reviews. Data sources: Three academic databases were searched for relevant literature in May 2022: MEDLINE, PsycINFO and CINAHL Plus. Inclusion criteria encompassed literature reviews that examined the topic of patient-centred care for any adult patients in end-of-life care. Results: A total of 92 literature reviews were identified. Findings suggest that there is often a discrepancy between patient preferences and the provision of care. These discrepancies have been associated with a range of barriers at the patient, staff and system levels. Common interventions included education and training for staff which were often met with improved patient outcomes. Patient-centred models of care were underrepresented across the literature. Conclusions: This review highlighted a need for healthcare systems to support staff in providing a patient-centred end of life experience through the development of a co-designed patient-centred model of care, supplemented by professional development and a systematic approach to identifying and documenting patient preferences.