bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report: 18F-FES PET/CT predicted treatment responses of second-line and third-line CDK4/6 inhibitors after disease progression on first-line CDK4/6 inhibitor in a HR+/HER2- metastatic breast cancer patient
Authors: Pan Bo , Hao Zhixin , Xu Ying , Wang Zhe , Yao Ru , Wang Xuefei , Ren Chao , Zhou Yidong , Sun Qiang , Huo Li 
Published: December 2022

BackgroundCyclin-dependent kinase 4/6 inhibitor (CDK4/6i) has become the commonest first-line treatment of hormonal receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer (MBC). However, therapy is quite individualized after progression of disease (PD) when CDK4/6i fails. Estrogen receptor (ER) status of metastatic lesions of bone, lung or liver might be different from the primary tumor and biopsy of metastatic lesions was invasive and not always available. Prediction of treatment response after PD of CDK4/6i remains unsolved. 18F-fluoroestradiol (FES) PET/CT could non-invasively reveal ER expression both in primary and metastatic breast cancer and recognize heterogeneity of ER status.Case presentationA 70-year-old woman with Parkinson’s disease, osteoporosis and cardiovascular co-morbidity was diagnosed with HR+/HER2- breast cancer (pT2N2M0, stage IIIa). Three years later, she developed metastases in right lung and pleura with pleural effusion and received palbociclib + letrozole. After 8 months the disease progressed, and 18F-FES PET/CT revealed multiple ER-positive pleural lesions and ER-negative pulmonary nodules after PD and the progression-free survival (PFS) of first-line CDK4/6i was 8 months. Since most of the metastatic lesions were ER-positive, abemaciclib + fulvestrant were chosen as the second-line CDK4/6i treatment and the PFS was 15 months. Another 18F-FES PET/CT showed a new ER-positive pleural mass with multiple ER-negative pulmonary nodules. Since 18F-FES PET/CT revealed that the dominant lesions were still ER-positive, dalpiciclib + exemestane + fulvestrant were prescribed as the third-line CDK4/6i treatment. Currently the patient’s disease had been stable for 2 months.ConclusionThis case demonstrated that 18F-FES PET/CT could show ER heterogeneity non-invasively and reveal the treatment responses a predictive imaging tool of serial second- and third-line of CDK4/6i treatments when first-line CDK4/6i failed in HR+/HER2- MBC. So long as the dominant or newly-developed metastatic lesion was ER-positive on 18F-FES PET after first-line CDK4/6i, the patient might show certain therapeutic response towards endocrine-based treatment including second- and third-line of CDK4/6i, and thus increased the time to chemotherapy (TTC).
Volume-guarantee vs. pressure-limited ventilation in evolving bronchopulmonary dysplasia
Authors: Cuevas Guaman Milenka , Hagan Joseph , Sabic Dajana , Tillman Davlyn M. , Fernandes Caraciolo J. 
Published: December 2022

IntroductionExtremely premature infants are at high risk for developing bronchopulmonary dysplasia (BPD). While noninvasive support is preferred, they may require ventilator support. Although volume-targeted ventilation (VTV) has been shown to be beneficial in preventing BPD, no data exists to guide ventilator management of infants with evolving BPD. Thus, clinicians employ a host of ventilator strategies, traditionally time-cycled pressure-limited ventilation (PLV) and more recently volume-guarantee ventilation (VGV) (a form of VTV). In this study, we sought to test the hypothesis that use of VGV in evolving BPD is associated with improved clinical and pulmonary outcomes when compared with PLV.DesignSingle-center, retrospective cohort review of premature infants born less than 28 weeks inborn to a Level 4 NICU from January 2015 to December 2020. Data abstracted included demographics, maternal and birth data, and ventilator data until death or discharge. Exposure to either VGV or PLV was also examined, including ventilator “dose” (number of time points from DOL 14, 21 and 28 the patient was on that particular ventilator) during the period of evolving BPD.ResultsOf a total of 471 patients with ventilation data available on DOL 14, 268 were not ventilated and 203 were ventilated. PLV at DOL 21 and 28 was associated with significantly higher risk of BPD and the composite outcome of BPD or death before 36 weeks compared to VGV. Both increasing VGV and PLV doses were significantly associated with higher odds of BPD and the composite outcome. For each additional time point of VGV and PLV exposure, the predicted length of stay (LOS) increased by 15.3 days (p &lt; 0.001) and 28.8 days (p &lt; 0.001), respectively.DiscussionOur study demonstrates the association of use of VGV at DOL 21 and 28 with decreased risk of BPD compared to use of PLV. Prospective trials are needed to further delineate the most effective ventilatory modality for this population with “evolving” BPD.
Wheat yield estimation using remote sensing data based on machine learning approaches
Authors: Cheng Enhui , Zhang Bing , Peng Dailiang , Zhong Liheng , Yu Le , Liu Yao , Xiao Chenchao , Li Cunjun , Li Xiaoyi , Chen Yue , Ye Huichun , Wang Hongye , Yu Ruyi , Hu Jinkang , Yang Songlin 
Published: December 2022

Accurate predictions of wheat yields are essential to farmers’production plans and to the international trade in wheat. However, only poor approximations of the productivity of wheat crops in China can be obtained using traditional linear regression models based on vegetation indices and observations of the yield. In this study, Sentinel-2 (multispectral data) and ZY-1 02D (hyperspectral data) were used together with 15709 gridded yield data (with a resolution of 5 m × 5 m) to predict the winter wheat yield. These estimates were based on four mainstream data-driven approaches: Long Short-Term Memory (LSTM), Random Forest (RF), Gradient Boosting Decision Tree (GBDT), and Support Vector Regression (SVR). The method that gave the best estimate of the winter wheat yield was determined, and the accuracy of the estimates based on multispectral and hyperspectral data were compared. The results showed that the LSTM model, for which the RMSE of the estimates was 0.201 t/ha, performed better than the RF (RMSE = 0.260 t/ha), GBDT (RMSE = 0.306 t/ha), and SVR (RMSE = 0.489 t/ha) methods. The estimates based on the ZY-1 02D hyperspectral data were more accurate than those based on the 30-m Sentinel-2 data: RMSE = 0.237 t/ha for the ZY-1 02D data, which is about a 5% improvement on the RSME of 0.307 t/ha for the 30-m Sentinel-2 data. However, the 10-m Sentinel-2 data performed even better, giving an RMSE of 0.219 t/ha. In addition, it was found that the greenness vegetation index SR (simple ratio index) outperformed the traditional vegetation indices. The results highlight the potential of the shortwave infrared bands to replace the visible and near-infrared bands for predicting crop yields Our study demonstrates the advantages of the deep learning method LSTM over machine learning methods in terms of its ability to make accurate estimates of the winter wheat yield.
How mobile phone addiction is associated with suicidal ideation in university students in China: Roles of depression and online social support
Authors: Hu Huahua , Yang Xue , Mo Phoenix K. H. , Zhao Chengjia , Kuang Beibei , Zhang Guohua , Lin Guangyao 
Published: December 2022

BackgroundRecent studies have highlighted mobile phone addiction (MPA) as a potential risk of suicidal ideation. However, the mechanisms underlying that association require attention.ObjectiveThis investigation aims to examine whether the relationship between MPA and suicidal ideation would be mediated by depression, and buffered by online social support (OSS) in university students.MethodsA convenient sample of 1,042 Chinese university students completed the measures of mobile phone addiction, depression, suicidal ideation, OSS in classroom settings. Moderated mediation analyses were performed to test the roles of depression and OSS in the association between MPA and suicidal ideation.ResultsMPA was positively associated with suicidal ideation through depression (indirect effect =. 23, 95% CI: 0.18, 0.28, p &lt; 0.001); OSS moderated the association between depression and suicidal ideation (B = − 0.09, 95% CI: −0.13, −0.04, p &lt; 0.001). Specifically, the effect of depression on suicidal ideation was weaker in individuals with high (versus low) OSS. OSS moderated the association between MPA and suicidal ideation (B = 0.06, 95% CI: 0.02, 0.10, p = 0.001). The influence of MPA on suicidal ideation was non-significant among individuals with high OSS but negatively significant among students with low OSS.ConclusionThe results enrich the understanding of how MPA may increase suicidal ideation, and highlight the potential importance of reducing depression and enhancing OSS to prevent suicidal ideation in university students.
The role of social-psychological factors of victimity on victimization of online fraud in China
Authors: Zhang Zhi , Ye Zhi 
Published: December 2022

IntroductionThe high incidence of online fraud in China poses a great threat to the social stability and property security of society. Victimity is the state or mindset of victims, referring to the various conditions related to being victims of crimes. Examining the association between the inherent and extrinsic factors of victimity and victimization of online fraud is of great importance for revealing the psychological mechanism of victimization and drawing up preventative measures.MethodsThrough the questionnaire survey of 504 online fraud victims and 523 non-victims, univariate analysis and logistic regression analysis were used to investigate the risk factors correlated with victimization.ResultsAge, education, and social support are positively correlated with fraud victimization, while impulsiveness, trust tendency, smartphone usage, and negative life experiences are negatively correlated with fraud victimization. Subsequent regression analyses showed that all the factors above, except for smartphone usage, are significant predictors for online fraud victimization.DiscussionOur conceptual model and empirical results demonstrate the important role of victimity in making an individual become a victim and help clarify the mixed findings of previous studies on the risk factors for online fraud.
Adult education needs inventory: Construction and application
Authors: Ślósarz Luba , Błaszczyński Kamil , Švecová Magdaléna , Kobylarek Aleksander 
Published: December 2022

BackgroundThe article presents the psychometric parameters and implementation of the adult education needs inventory (AENI) questionnaire, which is designed to measure the key competences of adult educators. It was constructed on the concept of key competences as proposed by the Council of the European Union. This model of competences is inscribed in the concept of lifelong learning and does not concentrate on the compensatory functions of the competences but merely promotes the insight of educators into their self-development. This article presents the construction process and psychometrical properties of AENI.Materials and methodsThe reliability of the test is confirmed by the inter-correlated results. The accuracy of the questionnaire was confirmed through principal component analysis (PCA). Apart from this, the accuracy of the theory was verified by a correlation between AENI and the Social Skills Profile (PROKOS), which measures the level of such social skills as assertiveness, cooperativeness, sociability, social resourcefulness, and social activeness. To check the accuracy of the theory, hypotheses were formulated which were related to both the correlated overall results (AENI and PROKOS) and the chosen scales.ResultsSix areas of need in development were distinguished: communication skills, multilingual and multicultural skills, digital skills, entrepreneurial skills, openness to science and culture, and social and civic skills. A low result on the scale indicates a need to develop a given skill because the respondent’s skills are weak. Such information is vital for employers and educators who wish to diagnose the areas that need improvement. The measures of reliability and accuracy allow us to state that the questionnaire possesses acceptable psychometrical factors. This study contains propositions for further improvement of the questionnaire and a key to interpreting the research results.ConclusionAdult education needs inventory questionnaire is a reliable research tool that can be used to assess the competences of adult educators. Also, it can be considered a voice of discussion regarding the necessity of raising the quality of education and raising the awareness of the education needs of individual adult educators and organizations that benefit from their services.
Akathisia after chronic usage of synthetic cathinones: A case study
Authors: Albert Niels , Catthoor Kirsten , Morrens Manuel 
Published: December 2022

IntroductionSynthetic cathinones are a heterogenous group of new psychoactive substances (NPS) with a surging prevalence of use. They are sold under the name of “Bath Salts,” “Legal Highs” or “Research Chemical.” It is a heterogeneous group of substances that have a varying binding selectivity and affinity. Due to limited availability of NPS screening tests, inadequate legislation, the exponential increases in availability of new NPS and the comorbid use of other illicit substances, scientific research remains scarce. As a result, insight in their mental and psychomotor effects is limited.Case descriptionWe present a case of a 21-year-old woman with daily usage of synthetic cathinones, more specifically α-Pyrrolidinopentiophenone (α-PVP-better known as “Flakka”), α-Pyrrolidinohexiophenone (α-PHP) and alpha-Pyrrolidinoisohexaphenone (α-PHiP). Besides a severe paranoid psychotic state of mind, characterized by persecutory and somatic delusions, there was also a very pronounced psychomotor restlessness during the whole period of hospitalization which was diagnosed as akathisia. She reported that she was unable to sit during meals, had difficulty standing still and felt a constant urge to pay attention to the restlessness. The patient did not take any antipsychotic medication at admission.ResultsThe patient was treated in accordance with the current guidelines concerning akathisia with a combination of Quetiapine 200 mg, Propranolol 80 mg, Diazepam 10 mg, Biperiden 4 mg, and Mirtazapine 15 mg without any sufficient alleviation of complaints. Before the start of the treatment, Barnes Akathisia Rating Scale (BARS) score was 11 out of 14 which evolved toward a score of 7 over the course of the 40 day hospitalization, implying persisting severe akathisia which only improved modestly.ConclusionThe current case suggests that besides cocaine, amphetamines and methamphetamines, synthetic cathinones can also increase the risk for development of extrapyramidal symptoms such as akathisia. Especially a-PVP-analogs as used by the current patient and Pyrovalerone-analogs such as Methylenedioxypyrovalerone (MDPV) are very powerful dopamine reuptake-inhibitors which might lead to strong locomotor activation. Up to this day it remains very difficult to establish a guideline concerning the treatment of intoxication with synthetic cathinones or dependence thereof.
A measurement method for mental health based on dynamic multimodal feature recognition
Authors: Xu Haibo , Wu Xiang , Liu Xin 
Published: December 2022

IntroductionThe number of college students with mental problems has increased significantly, particularly during COVID-19. However, the clinical features of early-stage psychological problems are subclinical, so the optimal intervention treatment period can easily be missed. Artificial intelligence technology can efficiently assist in assessing mental health problems by mining the deep correlation of multi-dimensional data of patients, providing ideas for solving the screening of normal psychological problems in large-scale college students. Therefore, we propose a mental health assessment method that integrates traditional scales and multimodal intelligent recognition technology to support the large-scale and normalized screening of mental health problems in colleges and universities.MethodsFirstly, utilize the psychological assessment scales based on human-computer interaction to conduct health questionnaires based on traditional methods. Secondly, integrate machine learning technology to identify the state of college students and assess the severity of psychological problems. Finally, the experiments showed that the proposed multimodal intelligent recognition method has high accuracy and can better proofread normal scale results. This study recruited 1,500 students for this mental health assessment.ResultsThe results showed that the incidence of moderate or higher stress, anxiety, and depression was 36.3, 48.1, and 23.0%, which is consistent with the results of our multiple targeted tests.ConclusionTherefore, the interactive multimodality emotion recognition method proposed provides an effective way for large-scale mental health screening, monitoring, and intervening in college students' mental health problems.
Establishment and evaluation of an in vitro blast lung injury model using alveolar epithelial cells
Authors: Ding Chunjie , Hong Shan , Zhang Miao , Sun Yunzhe , Li Ning , Zhang Jing , Ma Lan , Tian Linqiang , Ren Wenjie , Zhang Lin , Yao Sanqiao 
Published: December 2022

BackgroundGas explosion is a fatal disaster commonly occurred in coal mining and often causes systematic physical injuries, of which blast lung injury is the primary one and has not yet been fully investigated due to the absence of disease models. To facilitate studies of this field, we constructed an in vitro blast lung injury model using alveolar epithelial cells.MethodsWe randomly divided the alveolar epithelial cells into the control group and blast wave group, cells in the blast wave group were stimulated with different strengths of blast wave, and cells in the control group received sham intervention. Based on the standards we set up for a successful blast injury model, the optimal modeling conditions were studied on different frequencies of blast wave, modeling volume, cell incubation duration, and cell density. The changes of cell viability, apoptosis, intracellular oxidative stress, and inflammation were measured.ResultsWe found that cell viability decreased by approximately 50% at 6 h after exposing to 8 bar energy of blast wave, then increased with the extension of culture time and reached to (74.33 ± 9.44) % at 12 h. By applying 1000 ~ 2500 times of shock wave to 1 ~ 5 × 105 cells /ml, the changes of cell viability could well meet the modeling criteria. In parallel, the content of reactive oxide species (ROS), malonaldehyde (MDA), interleukin 18 (IL-18), tumor necrosis factor alpha (TNF-α), and transforming growth factor beta (TGF-β) increased in the blast wave group, while superoxide dismutase (SOD) and Glutathione -S- transferase (GST) decreased, which were highly consistent with that of human beings with gas explosion-induced pulmonary injury.ConclusionAn in vitro blast lung injury model is set up using a blast wave physiotherapy under 8 bar, 10 Hz blast wave on (1 ~ 5) ×105 alveolar epithelial cells for 1 000 times. This model is flexible, safe, and stable, and can be used for studies of lung injury caused by gas explosion and blast-associated other external forces.
Nutcracker syndrome: A case report and review of the literature
Authors: Kaur Ramandeep , Airey David 
Published: December 2022

BackgroundNutcracker syndrome (NS) is an uncommon condition resulting from the compression of the left renal vein (LRV) between the aorta and superior mesenteric artery (SMA), resulting in symptoms such as flank pain and hematuria.Case presentationWe present the case of a 30-year-old woman complaining of abdominal pain who was found to have nutcracker syndrome and treated with endovascular stenting of the left renal vein.DiscussionWe review the literature related to endovascular treatment of NS with focus on the distribution of the sizes of stents and rates of stent migration.ConclusionNC is a rare condition requiring a high index of suspicion for diagnosis. Endovascular treatment is a reasonable option, but its limitations must be considered.
THE ANALYZE OF FIGURATIVE LANGUAGE OF THE DOEL SUMBANG'S SONG LYRIC "BULAN BATU HIU"
Authors: Hakim Muhammad Wildan , Dewi Nenden Rikma 
Published: December 2022

Figurative language is used to express feelings by using particular style and dictions. It exist in various way, but it can be identified clearly in literary works and songs. Doel Sumbangâ€™s â€œBulan Batu Hiuâ€, for example, contains various type of figurative language. Thus, this research is aimed to find out the types of figurative language and meanings of figurative language in the Doel Sumbangâ€™s song Lyric â€œBulan Batu Hiuâ€. The methodology of this research is qualitative research. Data are taken from the lyric song. To analyze the issue, this research is using Knickerbocker and Williard Reninger (1963) ideas on classification of figurative language. As the result, Doel Sumbangâ€™s song Lyric â€œBulan Batu Hiuâ€ has two types of figurative language, personofocations and hyperboles. There are three personifications and three hyperboles types which describe connotative meaning.
ANALISIS JUKUGO BERAKHIRAN ～代 (DAI) DAN ～料 (RYOU) BERMAKNA BIAYA DALAM BAHASA JEPANG
Authors: Supriadi Zidan , Ali Mohammad 
Published: December 2022

Penelitian ini bertujuan untuk mendeskripsikan makna biaya yang ditunjukkan oleh jukugo kanji berakhiran ï½žä»£ (dai) dan ï½žæ–™ (ryou) bermakna biaya yang terdapat dalam buku Kamus Kanji Modern Jepang Indonesia karya Andrew N. Nelson, PH.D. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Berdasarkan hasil analisis, terdapat 12 makna biaya yang ditunjukkan jukugo berakhiran kanji ~ä»£ (dai) dan~æ–™ (ryou) dengan rincian : 2 makna biaya yang ditunjukkan oleh kanji berakhiran ~ä»£ (dai) yaitu (1) Biaya yang dikeluarkan untuk membeli atau menyewa suatu barang, (2) Biaya yang dikeluarkan untuk menyewa sebuah tempat serta fasilitas di dalamnya untuk tujuan tertentu. Kemudian 10 makna biaya yang ditunjukkan oleh kanji berakhiran ~æ–™ (ryou) yaitu (1) Biaya yang dikeluarkan untuk meminjam atau menyewa suatu barang, (2) Biaya yang dikeluarkan untuk menyewa sebuah tempat serta fasilitas di dalamnya untuk tujuan tertentu, (3) Biaya yang dikeluarkan sebagai imbalan jasa yang diterima oleh suatu pihak, (4) Biaya yang dikeluarkan sebagai imbalan perizinan memasuki suatu tempat atau wilayah, (5) Biaya yang dikeluarkan untuk membeli suatu barang, (6) Biaya yang dikeluarkan sebagai imbalan atau ucapan terima kasih, (7) Biaya yang dikeluarkan untuk mendapatkan hak atau izin kepemilikan suatu barang, (8) Biaya yang dikeluarkan untuk menggunakan jasa, barang, fasilitas secara berkala, (9) Biaya yang dikeluarkan untuk membayar kerugian yang dialami suatu pihak, dan (10) Biaya yang dikeluarkan setelah memakai suatu barang atau fasilitas.
REAKSI FORMASI PADA KARAKTER BRUCE WAYNE DALAM SERI FILM BATMAN
Authors: Ramadhan Yanuar , Tawami Tatan 
Published: December 2022

Tujuan dari penelitian ini adalah untuk menjelaskan mekanisme reaksi pembentukan yang dikeluarkan oleh karakter Bruce Wayne untuk meredam impuls dari struktur id. Pembentukan reaksi adalah jenis mekanisme pertahanan ego yang berusaha untuk mengurangi impuls kecemasan yang diciptakan oleh struktur id, yang menyebabkan tindakan yang tidak sejalan dengan apa yang ingin dilakukan atau dirasakan individu. Teknik penelitian ini mengkaji mekanisme perlindungan Bruce Wayne dalam film Batman Begins dengan menggunakan pendekatan kualitatif dengan gaya deskriptif (2005). Berdasarkan penelitian, karakter Bruce Wayne menggunakan formasi reaksi untuk membela orang lain. Untuk mengatasi tantangan yang dihadapinya, paradigma Bruce tentang pekerjaannya sebagai pelindung kota Gotham memaksanya untuk mengerahkan refleks formasi. Temuan penelitian ini diharapkan dapat digunakan sebagai model bagi peneliti lain untuk mengeksplorasi mekanisme pertahanan reaksi formasi secara lebih mendalam.
Kata Kunci: Reaksi formasi, Mekanisme Pertahanan, Bruce Wayne.