bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of dietary plant protein in older people
Authors: Gueugneau Marine 
Published: December 2022

Purpose of review
The current review provides an update on recent research regarding plant-based protein and their nutritional quality for older people.

Recent findings
There is growing evidence that plant-based proteins may be a valuable strategy for older people to prevent the health risks associated with consuming animal products and to promote better protein intake, as plant-based protein sources are rich in fibres and micronutrients. Although plant-based proteins are less anabolic than animal-derived proteins due to lower digestibility and deficiencies in some essential amino acids, several innovations in food processing and nutritional strategies have been developed to improve the quality of plant-based proteins. For example, the use of protein blends or green-processes as fermentation or germination could improve the nutritional qualities of plant-based foods that could be beneficial for older people, especially to prevent sarcopenia or metabolic disorders such as diabetes, obesity and cardiovascular diseases.

Summary
The use of plant-based protein sources could help older people diversify their protein sources and more easily meet recommended nutritional intake. Recent literature highlights several health benefits associated with increased consumption of vegetable foods. However, their efficiency on postprandial muscle protein synthesis remains to be evaluated and long-term studies are needed.
Old age: the crown of life, our play's last act. Question and answers on older patients undergoing allogeneic hematopoietic cell transplantation
Authors: Maffini Enrico , Festuccia Moreno , Ursi Margherita , Barbato Francesco , Dicataldo Michele , Roberto Marcello , Campanini Elena , Dan Elisa , De Felice Francesco , De Matteis Serena , Storci Gianluca , Bonafè Massimiliano , Arpinati Mario , Bonifazi Francesca 
Published: December 2022

Purpose of review
Several studies showed that age alone should not be used as an arbitrary parameter to exclude patients from allogeneic hematopoietic cell transplantation (HCT). The accessibility to allogeneic HCT programs for older patients with hematological diseases is growing up constantly. The Center for International Blood and Marrow Transplant Research has recently shown that over 30% of allogeneic HCT recipients are at least 60 years old and that nearly 4% are aged 70 or more. Historically, the use of allogeneic HCT among elderly patients has been limited by age restrictions, reflecting physicians’ concerns regarding prohibitive transplant-related mortality and HCT-associated morbidity.

Recent findings
The introduction of reduced intensity/toxicity conditioning regimens has allowed transplant Centers to carry out allogeneic HCT on patients previously considered not ideal candidates. The integration of specific risk scores could lead to better capture mental and physical frailties of older patients. Older adults less frequently have available medically fit siblings, able to donate, so, unrelated donors, familial haploidentical donors or umbilical cord blood grafts could potentially abrogate such a difficulty, allowing the curative potential of allogeneic HCT.

Summary
The appropriate assessing of allogeneic HCT feasibility for elderly patients should be the resonate application of different clinical and biological principles.
Experience of Physical Activity in Breast Cancer Survivors
Authors: Zhang Jia-Yuan , Zhang Yi-Bin , Zhou Yu-Qiu 
Published: December 2022

Background
Physical activity plays an important role in the recovery of breast cancer survivors. However, previous studies have shown that most breast cancer survivors have inadequate levels of physical activity.

Objective
This study aimed to explore the influencing factors of physical activity in breast cancer survivors.

Methods
Twelve participants aged 38 to 65 years who had completed surgery and related treatment for breast cancer were recruited from the outpatient service of a hospital in Daqing, China. The phenomenological method was used in this qualitative research. Semistructured interviews were conducted to explore the influencing factors of physical activity in breast cancer survivors. Colaizzi’s 7-step analysis method was used to code the data and identify descriptive themes.

Results
Four themes affecting the daily physical activity of breast cancer patients were extracted: perception and motivation (knowledge about benefits, goals, and motivation for physical activity), symptom burden (psychological and physical symptoms), social support (support from oncology staff, family, and peers) and environmental resources (seasonal impact, community resources).

Conclusion
The physical activity of breast cancer survivors is affected by many factors. Oncology providers need to strengthen assessment, identify barriers, and provide interventions to promote the patients’ participation in physical activity and to improve their quality of life.

Implication for Practice
It is necessary for providers to integrate medical and social support resources, use strategies to enhance motivation, and effectively solve barriers to increase physical activity in breast cancer survivors.
The Impact of Leadership in the Autonomy and Engagement of Nurses
Authors: Junttila Kristiina , Heikkilä Anniina , Heikkilä Asta , Koivunen Marita , Lehtikunnas Tuija , Mattila Elina , Meriläinen Merja , Peltokoski Jaana , Sneck Sami , Tervo-Heikkinen Tarja 
Published: December 2022

OBJECTIVE
To add to the body of evidence regarding nurse engagement and related factors from a non-US sample of nurses.

BACKGROUND
Leadership has a positive impact on nurses' autonomy and engagement experiences. It is necessary to explore the factors that explain the relationships between leadership, autonomy, and engagement level.

METHODS
Nurses (n = 4393) from 9 hospitals participated in a survey in March 2020. Multivariable logistic regression analysis was performed to identify engagement and autonomy predictors.

RESULTS
Of the respondents, 9% were engaged, 28% content, 29% ambivalent, and 34% disengaged. Respondents' separate background variables were not significant predictors in multivariate models, whereas the leadership- and autonomy-related variables were.

CONCLUSIONS
A manager's responsiveness, an organization's readiness to follow nurse suggestions for performance improvement, and receiving recognition and regular feedback promote engagement. Furthermore, engagement is enhanced when nurses have an active role in decision-making and their contributions are respected. Visible nurse managers and leaders who are effective advocates for nurses strengthen nurses' autonomy.
Changes in Posttraumatic Growth After a Virtual Contemplative Intervention During the COVID-19 Pandemic
Authors: Pfeiffer Katherine , Cunningham Tim , Cranmer John N. , Harrison Timothy , Crosby Hannah , Schroeder Karla , Jordan Dorothy , Coburn Caroline 
Published: December 2022

OBJECTIVE
The aim of this study was to describe the effects of an intervention called “Compassion & Growth Workshops” on reported posttraumatic growth (PTG) using the Posttraumatic Growth Inventory–Expanded (PTGI-X).

BACKGROUND
Few studies measure the impact of interventions, such as contemplative practices, on nurse PTG.

METHODS
We delivered a series of three 2-hour microretreats to nurses and advanced practice nurses and measured their impact on PTG scores. Using multivariate logistic regression, we identified cofactors predictive of 25% overall improvement on the PTGI-X.

RESULTS
Overall PTG increased among participants, with the greatest improvement in relating to others, new possibilities, and personal strength. Posttraumatic growth improved as workshop attendance increased; nurses providing direct patient care also benefitted the most.

CONCLUSIONS
Contemplative interventions can substantively improve PTG. This may be particularly relevant for coping with COVID pandemic stress among nurses on the frontlines and for healthcare leaders seeking to strengthen psychological support within their teams and reform the workplace environment.
Assessing Nursing Sentiments on Nurse-Resident Physician Collaboration and Administrative Support in the Labor and Delivery Setting
Authors: Durbin Jeffery S. , Dziadkowiec Oliwier , Choi Ye Ji , Swan Kimberly , Thrasher Susan M. 
Published: December 2022

OBJECTIVE
To develop a survey instrument that: 1) investigates the dynamics of collaboration in multidisciplinary care units such as labor and delivery (L&D); and (2) uniquely determines the collaborative relationships between nurses and resident physicians.

BACKGROUND
An effective interprofessional collaboration between healthcare providers is considered a critical component in delivering high-quality care to patients and lies at the root of ensuring positive patient outcomes.

METHODS
Two samples of responses (n = 98) were collected from L&D nurses working in 2 hospitals: 1 with novel obstetrics and gynecology (OB/GYN) residency program and 1 with legacy OB/GYN residency program. Descriptive statistics and reliability statistics (Cronbach's α and item-total correlations) were calculated for each sample.

RESULTS
Reliability analysis revealed strong internal consistency of the survey items in both samples even after completing single-item deletion analysis.

CONCLUSIONS
Findings suggest that our 11-item instrument shows promise in effectively assessing nursing sentiments toward collaboration with resident physicians.
The Yin and Yang of Primary Unilateral Cleft Lip and Nose Repair: Balance through understanding the opposing cleft and non-cleft side changes
Authors: Massenburg Benjamin B. , Mercan Ezgi , Ettinger Russell E. , Tse Raymond W. 
Published: December 2022

Introduction:
Balance is achieved through opposing interactions. Objective 3D assessment of changes during surgical treatment of the unilateral cleft lip and nasal deformity are limited and false assumptions may prevent optimal management.

Methods:
We performed anthropometric analysis on the immediate pre- and post-operative images (captured under anesthetic) of patients undergoing primary repair (n=36). Changes in dimensions and measures of balance were assessed (p<0.05).

Results:
Angles and ratios that reflect cleft to non-cleft side balance normalized, though alterations occurred in opposing ways. Centralization of the columella narrowed the cleft nasal base and widened the non-cleft nasal base. As the cleft columellar height elongated, the non-cleft columellar height shortened. With these changes and correction of cleft alar base retrusion, the cleft alar dome was raised. The cleft and non-cleft lateral lip heights and widths elongated while the Cupid’s bow broadened, and the commissures were drawn closer together. Whereas the cleft philtral height lengthened, the non-cleft philtral height shortened. Reduction in non-cleft philtral height averaged 20% but varied with measures of pre-operative severity including columellar angle (R=0.67), the difference in philtral heights (R=0.65), and lateral deviation of subnasale (R=0.74).

Conclusions:
Tissue does not need to be added to “lengthen” the columella, non-cleft philtral height shortening can be estimated, and morphology of anatomic subunits change with surgery on both cleft and non-cleft sides. It is inadequate to focus on correction of the cleft side alone without considering corresponding non-cleft side changes. Achieving balance through opposing alterations should be the principal goal of treatment.
Inside Looking Out
Authors: Vaughn Stephanie , Rye Jill , Allen Angela , Bok Amy , Mauk Kris , Park Linda , Pierce Linda , Wintersgill Holler Wendy 
Published: December 2022

Abstract

Background
The original Association of Rehabilitation Nurses (ARN) Competency Model for Professional Rehabilitation Nursing published in 2016, and updated in 2020, provides a framework for rehabilitation nursing practice.

Aim
This companion, but stand-alone, article to a 2022 publication further explicates and informs the updated Competency Model from inside looking out toward an increasing application for evidence-based practice (EBP).

Approach
An eight-member 2020 ARN Task Force used an iterative process to review the original four domains and related competencies and came to consensus for the updated model.

Outcome
This model provides revised competency role descriptors or behaviors that guide nurses practicing at different proficiency levels in various settings.

Clinical Relevance
The Competency Model for Professional Rehabilitation Nursing is a premier resource that can advance professional rehabilitation nursing and guide EBP, including evaluation, quality improvement, and research. The model describes the nurse’s role on the intra/interprofessional team and fosters collaboration with other healthcare professionals to enhance the quality of life for those affected by disability and chronic illness.

Conclusion
The domains and associated competencies of this model clarify nursing roles at different proficiency levels, and role descriptors reflect current practice, supporting advancement of the specialty practice of rehabilitation nursing well into the 21st century.
The Surgeon as a Professional
Authors: Noda Christopher H. , Brown Doug , Kopar Piroska K. 
Published: December 2022

Objective:
In this article, we seek to use a case-study discussion of a woman seeking treatment guidance for an elective, complex surgical ailment to discuss how professionalism has changed within the past century and where it may be headed with specific regard for the medical profession and surgeons.

Background:
Traditionally, professionals were those who possessed a certain knowledge base, committed to an ╗altruistic mission through serving the general populace while adhering to certain performance standards that were established by other members of the field. In the 20th century, we saw certain abuses from those who held positions of power within medicine including the Tuskegee Syphilis and Nuremberg trials calling into question the trust the public has placed within professional actors. With many competing opinions and forces shaping the medical profession, including the prominent dissemination of health care information making access to both true and misinformation more rampant than ever before, discussion about the evolving nature of the medical profession is important.

Methods/Results:
We conducted a literature review to investigate the historical context of the physician–patient relationship with regard for the surgeon. Our work suggests that the core structure of a professional is a foundation rooted in moral excellence that merits trust from the client. In medicine, further efforts at healing from prior abuses necessitates an emphasis on ethical principles, as well as communicating this commitment not only to the patient but also to the society at large. We emphasize the importance of these changes through a case-based discussion.
Different Dosage Regimens of Tanezumab for the Treatment of Chronic Low Back Pain: A Meta-analysis of Randomized Controlled Trials
Authors: Lian Jinrong , Wang Jiahe , Li Xiang , Yang Siyuan , Li Hang , Zhong Yi , Gao Heng , Chen Gang 
Published: December 2022

Objective
The aim of this study was to assess the efficacy of different dosage regimens of tanezumab among individuals living with chronic low back pain (CLBP).

Methods
PubMed, Embase, The Cochrane Library, and other databases were searched from inception until August 2021. Randomized controlled trials investigating the efficacy and safety of tanezumab in individuals with CLBP were included. Data were extracted independently by 2 investigators and assessed the study quality by the Cochrane risk-of-bias tool. The measurements include low back pain intensity and Roland-Morris Disability Questionnaire. The incidence of adverse events and serious adverse events was set to assess the safety of tanezumab for CLBP.

Results and Discussion
Three high-quality randomized controlled trials with 3414 patients were finally included in our analysis. Tanezumab, respectively, led to a notable decrease compared with placebo in low back pain intensity (mean difference, −0.62; 95% confidence interval [CI], −0.77 to −0.46; P < 0.01) and Roland-Morris Disability Questionnaire (mean difference, −0.64; 95% CI, −0.80 to −0.47; P = 0.01). In addition, no significant difference existed between tanezumab and placebo groups (risk ratio, 1.10; 95% CI, 0.81–1.49; P = 0.55) in the adverse events and (risk ratio, 1.06; 95% CI, 0.34–3.27; P = 0.93) serious adverse events.

Conclusions
Intravenous and subcutaneous tanezumab injections as treatment for improving CLBP have promising clinical application as its great improvement on all efficacy and its controllable safety issues. Furthermore, intravenous and subcutaneous tanezumab injections were proved to achieve excellent and long-term curative effect on CLBP through our subgroup analysis and comparison.
Lower respiratory tract microbiome composition and community interactions in smokers
Authors: Campos Michael , Cickovski Trevor , Fernandez Mitch , Jaric Melita , Wanner Adam , Holt Gregory , Donna Elio , Mendes Eliana , Silva-Herzog Eugenia , Schneper Lisa , Segal Jonathan , Amador David Moraga , Riveros Juan Daniel , Aguiar-Pulido Vanessa , Banerjee Santanu , Salathe Matthias , Mathee Kalai , Narasimhan Giri 
Published: December 2022

The lung microbiome impacts lung function, making any smoking-induced changes in the lung microbiome potentially significant. The complex co-occurrence and co-avoidance patterns between the bacterial taxa in the LRT microbiome were explored for a cohort of active (AS), former (FS), and never (NS) smokers. Bronchoalveolar lavages (BAL) were collected from 55 volunteer subjects (nine NS, 24 FS, and 22 AS). The LRT microbiome composition was assessed using 16S rRNA amplicon sequencing. Identification of differentially abundant taxa, co-occurrence patterns, discriminant analysis, and biomarker inferences were performed. The data show that smoking results in a loss in the diversity of the lower respiratory tract (LRT) microbiome, change in the co-occurrence patterns, and a weakening of the tight community structure present in healthy microbiomes. The increased abundance of Ralstonia genus in the lung microbiomes of both former and active smokers is significant.
Partial least square discriminant and DESeq2 analyses suggested a compositional difference between the cohorts in the LRT microbiome. The groups were sufficiently distinct from each other, suggesting that cessation of smoking may not be sufficient for the lung microbiota to return to a composition similar to that of never smokers. The LEfSe analyses identified several bacterial taxa as potential biomarkers of smoking status. Network-based clustering analysis highlighted different co-occurring and co-avoiding microbial taxa in the three groups. The analysis found a cluster of bacterial taxa that co-occur in smokers and non-smokers alike. The clusters exhibited tighter and more significant associations in NS compared to FS and AS. Higher degree of rivalry between clusters was observed in the AS. The groups were sufficiently distinct from each other, suggesting that cessation of smoking may not be sufficient for the lung microbiota to return to a composition similar to that of never smokers.
An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody responsein vivo
Authors: Zhang Quan , Wang Miao , Han Chunle , Wen Zhijun , Meng Xiaozhu , Qi Dongli , Wang Na , Du Huanqing , Wang Jianhong , Lu Lu , Ge Xiaohu 
Published: December 2022

AbstractThe severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) that causes the coronavirus disease 2019 (COVID-19) has presented numerous challenges to global health. The vaccines, including lipid-based nanoparticle mRNA, inactivated virus and recombined protein, have been used to prevent SARS-CoV-2 infections in clinics and are immensely helpful against the epidemic. Here, we first present an oral mRNA vaccine based on bovine milk-derived exosomes (milk-exos), which encodes the SARS-CoV-2 receptor binding domain (RBD) as an immunogen. The results indicated that RBD mRNA delivered by milk-derived exosomes can produce secreted RBD peptide in 293 cellsin vitroand stimulated neutralizing antibodies against RBD in mice. These results indicated that bovine milk-derived exosome-based mRNA vaccine could serve as a new strategy for preventing SARS-CoV-2 infection. Meanwhile, it also can work as a new oral delivery system for mRNA.One Sentence SummaryOral SARS-CoV-2 mRNA vaccine based on bovine milk-derived exosomes can stimulate neutralizing antibodies in mice.
A hierarchical model for external electrical control of an insect, accounting for inter-individual variation of muscle force properties
Authors: Owaki Dai , Dürr Volker , Schmitz Josef 
Published: December 2022

AbstractCyborg control of insect movement is promising for developing miniature, high-mobility, and efficient biohybrid robots. However, considering the inter-individual variation of the insect neuromuscular apparatus and its neural control is challenging. We propose a hierarchical model including inter-individual variation of muscle properties of three leg muscles involved in propulsion (retractor coxae), joint stiffness (pro- and retractor coxae), and stance-swing transition (protractor coxae and levator trochanteris) in the stick insectCarausius morosus. To estimate mechanical effects induced by external muscle stimulation, the model is based on the systematic evaluation of joint torques as functions of electrical stimulation parameters. A nearly linear relationship between the stimulus burst duration and generated torque was observed. This stimulus-torque characteristic holds for burst durations of up to 500 ms, corresponding to the stance and swing phase durations of medium to fast walking stick insects. Hierarchical Bayesian modeling revealed that linearity of the stimulus-torque characteristic was invariant, with individually varying slopes. Individual prediction of joint torques provides significant benefits for precise cyborg control.
Rapid recall andde novoT cell responses during SARS-CoV-2 breakthrough infection
Authors: Koutsakos Marios , Reynaldi Arnold , Lee Wen Shi , Nguyen Julie , Amarasena Thakshila , Taiaroa George , Kinsella Paul , Liew Kwee Chin , Tran Thomas , Kent Helen E , Tan Hyon-Xhi , Rowntree Louise C , Nguyen Thi H O , Thomas Paul G , Kedzierska Katherine , Petersen Jan , Rossjohn Jamie , Williamson Deborah A , Khoury David , Davenport Miles P , Kent Stephen J , Wheatley Adam K , Juno Jennifer A 
Published: December 2022

AbstractWhile the protective role of neutralising antibodies against COVID-19 is well-established, questions remain about the relative importance of cellular immunity. Using 6 pMHC-multimers in a cohort with early and frequent sampling we define the phenotype and kinetics of recalled and primary T cell responses following Delta or Omicron breakthrough infection. Recall of spike-specific CD4+T cells was rapid, with cellular proliferation and extensive activation evident as early as 1 day post-symptom onset. Similarly, spike-specific CD8+T cells were rapidly activated but showed variable levels of expansion. Strikingly, high levels of SARS-CoV-2-specific CD8+T cell activation at baseline and peak were strongly correlated with reduced peak SARS-CoV-2 RNA levels in nasal swabs and accelerated clearance of virus. Our study demonstrates rapid and extensive recall of memory T cell populations occurs early after breakthrough infection and suggests that CD8+T cells contribute to the control of viral replication in breakthrough SARS-CoV-2 infections.