bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of lubrication performance of sliding pairs with multi-depth groove textures based on genetic algorithm
Authors: Li Shaojun , Wu Zhenpeng , Dong Bowen , Luo Wenyan , Song Hailong , Guo Haotian , Zhou And Qiqi 
Published: May 2023

Abstract
During the wear and tear process of bearings, the friction coefficient between the friction pairs can be effectively decreased by employing the suitable surface texture on the frition surface. In the study, the distribution and depth variation of the surface texture were used as variables, and the genetic algorithm was used for iterative optimization to obtain the optimal texture distribution and depth. The friction and wear performance of the rectangular texture bearing sliding blocks was optimized. The depth of the texture was represented by a 4-bit binary number, and different binary numbers were set to represent different texture depths. Finally, the genetic algorithm was used for continuous iteration and evolution to obtain the optimal texture combination. The study showed that, compared with the regular texture with a depth of 0.2 μm, the friction coefficient decreased by 15.0% under the optimal texture with a non-uniform depth. Simultaneously, compared with the regular 3 μm deep texture, texture with a optimized depth makes the friction coefficient decreased by 37.5%, and the minimum oil film thickness increased by 0.979 μm. The optimal texture and oil film thickness combination obtained from the study can effectively reduce solid contact force and alleviate mechanical wear.
A strain rate dependent model with decreasing Young’s Modulus for cortical human bone
Authors: Sánchez-Molina D , García-Vilana S , Martínez-Sáez L , Llumà J 
Published: May 2023

Abstract
In the existing literature, some studies have observed an increase in the elastic modulus of human cortical bone with strain rate, which has been described as a consequence of the viscoelastic properties of the bone. However, these results contradict the findings of other studies, in which an independence or decrease of the elastic modulus with strain rate is observed, which could be explained by other non-viscoelastic mechanisms. This research studies the dynamic behavior of human cortical bone specimens and investigates their mechanical properties . A full and objective strain rate dependent model is proposed and used to describe the experimental results obtained from uniaxial tensile tests of twenty-one human rib cortical bone specimens from twelve male post mortem human subjects (average age of 68.5 ± 12.3 years). In addition, a general discussion of some families of viscoelastic models is given and the caution with which they should be used when dealing with complex materials such as bone. The main experimental finding is that in the range of strain rate analyzed (

ε

̇

=
0.10
−
0.60

), there is a significant decrease in Young’s modulus (E ≈ 18 GPa for

ε

̇

=
0.10

s

−
1

and E ≈ 8 GPa for

ε

̇

=
0.50

s

−
1

), which is not of viscoelastic origin. Moreover, the most frequently used viscoelastic models analyzed in this study predict how the elastic modulus should not vary markedly with strain rate for small strains. In fact, the observed behavior seems related to the findings of other researchers who observed that the microcraking damage depends on the strain rate in the same sense found in our work. This allows us to interpret the qualitative results as a consequence of the microcracking that takes place within the cortical bone, and not related to viscoelastic effects.
Science and policy lessons learned from a decade of adaptation to the emergent risk of sargassum proliferation across the tropical Atlantic
Authors: Dominguez Almela Victoria , Addo Kwasi Appeaning , Corbett Jack , Cumberbatch Janice , Dash Jadu , Marsh Robert , Oxenford Hazel , Tonon Thierry , Van Der Plank Sien , Webber Mona , Tompkins Emma L 
Published: May 2023

Abstract
Climatic and anthropogenic changes appear to be driving the emergence of new ecosystem and human health risks. As new risks emerge, and the severity or frequency of known risks change, we ask: what evidence is there of past adaptations to emergent risks? What scientific and policy processes lead to adaptive solutions that minimise the impacts of these events, and draw out opportunities? We identify science and policy lessons learned from coping with, and responding to, the sudden arrival of brown macroalgae (pelagic sargassum) that has proliferated across the tropical Atlantic since 2011. Drawing on an evidence base developed from a systematic search of literature relating to sargassum seaweed, and using event timelines and word clouds, we provide an analysis of lessons learned from a case study of adaptive responses across three continents to an emergent risk over the course of a decade. We reflect on successes and failures as well as opportunities taken in building adaptive capacity to address the risk in four key domains: policy, knowledge and evidence, monitoring and early warning, and technology and valorisation. Failures include: lack of environmental risk registries; missed opportunities to share monitoring data; and lack of a shared approach to manage the risk. Successes include: development of national management strategies; open-access knowledge hubs, networks and webinars sharing information and best practice; semi-operational early advisory systems using open access remote sensing data; numerous innovations customising clean-up and harvesting equipment, and research and development of new uses and value-added products.
The Influence of Age on Complications After Correction of Congenital Breast Deformities: A National Analysis of the Pediatric and Adult NSQIP Data Sets
Authors: Sergesketter Amanda R , Geng Yisong , Tian William M , Langdell Hannah C , Shammas Ronnie L , Knackstedt Rebecca , Rezak Kristen 
Published: May 2023

Abstract

Background
Timing of surgical intervention is controversial among patients seeking correction of congenital breast deformities.

Objectives
This study aimed to assess the influence of age on 30-day complications and unplanned healthcare utilization after reconstruction of congenital breast deformities.

Methods
Female patients undergoing breast reconstruction for congenital breast deformities and Poland syndrome were identified on the basis of International Classification of Diseases (ICD) codes in the 2012 to 2021 pediatric and adult National Surgical Quality Improvement Project (NSQIP) data sets. Complications based on age at correction were compared, and multivariate logistic regression was used to identify predictors of overall and wound healing complications.

Results
Among 528 patients meeting inclusion criteria, mean (SD) age at surgical correction was 30.2 (13.3) years. Patients most commonly underwent implant placement (50.5%), mastopexy (26.3%), or tissue expander placement (11.6%). Across the cohort, overall incidence of postoperative complications was 4.4%, most commonly superficial surgical site infection (1.0%), reoperation (1.1%), or readmission (1.0%). After multivariate adjustment, increasing age at time of correction was associated with higher incidence of wound complications [odds ratio (OR) 1.001; 95% confidence interval (CI) 1.0003-1.002; P = .009], in addition to BMI (OR 1.002; 95% CI 1.0007-1.004; P = .006) and tobacco use (OR 1.06; 95% CI 1.02-1.11; P = .003).

Conclusions
Breast reconstruction for congenital breast deformities may be safely undertaken at a young age with a low associated risk of postoperative complications. Large, multi-institutional studies are needed to assess the influence of surgical timing on psychosocial outcomes in this population.
DiMo: discovery of microRNA motifs using deep learning and motif embedding
Authors: Farhadi Fatemeh , Allahbakhsh Mohammad , Maghsoudi Ali , Armin Nadieh , Amintoosi Haleh 
Published: May 2023

Abstract
MicroRNAs are small regulatory RNAs that decrease gene expression after transcription in various biological disciplines. In bioinformatics, identifying microRNAs and predicting their functionalities is critical. Finding motifs is one of the most well-known and important methods for identifying the functionalities of microRNAs. Several motif discovery techniques have been proposed, some of which rely on artificial intelligence-based techniques. However, in the case of few or no training data, their accuracy is low. In this research, we propose a new computational approach, called DiMo, for identifying motifs in microRNAs and generally macromolecules of small length. We employ word embedding techniques and deep learning models to improve the accuracy of motif discovery results. Also, we rely on transfer learning models to pre-train a model and use it in cases of a lack of (enough) training data. We compare our approach with five state-of-the-art works using three real-world datasets. DiMo outperforms the selected related works in terms of precision, recall, accuracy and f1-score.
Genome mining for anti-CRISPR operons using machine learning
Authors: Yang Bowen , Khatri Minal , Zheng Jinfang , Deogun Jitender , Yin Yanbin 
Published: May 2023

Abstract

Motivation
Encoded by (pro-)viruses, anti-CRISPR (Acr) proteins inhibit the CRISPR-Cas immune system of their prokaryotic hosts. As a result, Acr proteins can be employed to develop more controllable CRISPR-Cas genome editing tools. Recent studies revealed that known acr genes often coexist with other acr genes and with phage structural genes within the same operon. For example, we found that 47 of 98 known acr genes (or their homologs) co-exist in the same operons. None of the current Acr prediction tools have considered this important genomic context feature. We have developed a new software tool AOminer to facilitate the improved discovery of new Acrs by fully exploiting the genomic context of known acr genes and their homologs.

Results
AOminer is the first machine learning based tool focused on the discovery of Acr operons (AOs). A two-state HMM (hidden Markov model) was trained to learn the conserved genomic context of operons that contain known acr genes or their homologs, and the learnt features could distinguish AOs and non-AOs. AOminer allows automated mining for potential AOs from query genomes or operons. AOminer outperformed all existing Acr prediction tools with an accuracy = 0.85. AOminer will facilitate the discovery of novel anti-CRISPR operons.

Availability and implementation
The webserver is available at: http://aca.unl.edu/AOminer/AOminer_APP/. The python program is at: https://github.com/boweny920/AOminer.
O031 A systematic review and meta-analysis of the relationship between alcohol consumption and postoperative outcomes in gastrointestinal surgery
Authors: Angus R , Humes D J , Adiamah A , Leow T 
Published: May 2023

Abstract

Introduction
Alcohol is a modifiable risk factor in patients having planned surgery and problematic drinking is an increasing problem. To date, no systematic review solely focuses on outcomes following gastrointestinal surgery and their relationship with alcohol use. This study aimed to summarize the evidence of the association between preoperative alcohol consumption and postoperative complications in gastrointestinal surgeries.

Methods
Comprehensive searches of MEDLINE, EMBASE, and Cochrane databases was undertaken to identify original studies investigating the association between preoperative alcohol consumption and postoperative complications occurring within 30 days of surgery. The primary outcome was 30-day mortality risk and secondary outcomes included postoperative complications such as surgical site infections and risk of anastomotic leak. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a random effects model.

Results
In total, 3182 reports were identified and reviewed for eligibility, and data was extracted from 26 studies that met inclusion criteria. 14 studies were included in the meta-analysis. Clearly defined high preoperative alcohol consumption was associated with an increased risk of 30-day mortality (Odds ratio (OR)=1.56; 95% confidence interval (CI):1.07–2.28). High alcohol intake was also associated with an increased risk of anastomotic leak following colorectal surgery (OR 2.17 (95% CI: 1.74–2.72) and an increase in risk of surgical site infections (OR=1.32; 95% CI: 1.15- 1.53).

Conclusion
Preoperative alcohol consumption was associated with an increased risk of 30-day mortality, risk of anastomotic leakage and surgical site infections. Preoperative modulation of alcohol intake may influence post-operative complications after gastrointestinal surgery.
O134 Does robotic anterior resection improve the outcomes for patients with rectal cancer over standard laparoscopic surgery?
Authors: Nwabueze M , McPherson S 
Published: May 2023

Abstract

Introduction
Currently, laparoscopic anterior resection (L-AR) is the standard approach for rectal cancer (RC) treatment. Increasingly, AR procedures have been conducted robotically using the Da Vinci Surgical System (DVSS). Its design has the potential to improve upon the operative outcomes of L-AR. However, the DVSS's controversial price of $2,000,000 has slowed its clinical adoption. There has been speculation as to whether the clinical outcomes conferred by robotic-assisted AR (R-AR) merits the cost of the DVSS.

Aims
To review the literature on R-AR and L-AR surgery for RC, primarily comparing the clinical outcomes of each approach, with an auxiliary evaluation of cost-effectiveness.

Methods
A literature search was performed using the databases OVID Embase, MedLine, and Web of Science. The keywords ‘anterior resection’, ‘rectal neoplasm’, ‘robotics’, ‘robotic surgical procedures’, and ‘laparoscopy’ were entered into each database. 141 records were initially retrieved and screened for relevance. The remaining texts that were fully available and adhered to the eligibility criteria were included in this review.

Results
Ten studies were identified. R-AR resulted in higher quality TME specimens in three studies, (p=0.02, 0.03, 0.033). and in shorter hospital stays and longer operative times in four studies: (p=0.03, 0.0001&lt;, 0.001&lt;, 0.001). Overall, R-AR had lower rates of intraoperative complications.

Conclusion
Generally, R-AR seemed to deliver better outcomes, but there is insufficient evidence to establish its superiority over L-AR. Longitudinal studies with extended research periods are required to evaluate the long-term oncological benefits of R-AR.
Defunctioning loop ileostomy in anterior resection for rectal cancer and subsequent renal failure: nationwide population-based study
Authors: Rutegård Martin , Häggström Jenny , Back Erik , Holmgren Klas , Wixner Jonas , Rutegård Jörgen , Matthiessen Peter , Sjöström Olle 
Published: May 2023

Abstract

Background
Electrolyte disturbances and dehydration are common after anterior resection for rectal cancer with a defunctioning loop ileostomy. High-quality population-based studies on the impact of a defunctioning loop ileostomy on renal failure are lacking.

Methods
This was a nationwide observational study, based on the Swedish Colorectal Cancer Registry of patients undergoing anterior resection for rectal cancer between 2008 and 2016, with follow-up until 2017. Patients with severe co-morbidity, with age greater than 80 years, and with pre-existing renal failure were excluded. Loop ileostomy at index surgery constituted exposure, while a diagnosis of renal failure was the outcome. Acute and chronic events were analysed separately. Inverse probability weighting with adjustment for confounding derived from a causal diagram was employed. Hazards ratios (HRs) with 95 per cent c.i. are reported.

Results
A total of 5355 patients were eligible for analysis. At 5-year follow-up, all renal failure events (acute and chronic) were 7.2 per cent and 3.3 per cent in the defunctioning stoma and no stoma groups respectively. In the weighted analysis, a HR of 11.59 (95 per cent c.i. 5.68 to 23.65) for renal failure in ostomates was detected at 1 year, with the largest effect from acute renal failure (HR 24.04 (95 per cent c.i. 8.38 to 68.93)). Later follow-up demonstrated a similar pattern, but with smaller effect sizes.

Conclusion
Patients having a loop ileostomy in combination with anterior resection for rectal cancer are more likely to have renal failure, especially early after surgery. Strategies are needed, such as careful fluid management protocols, and further research into alternative stoma types or reduction in stoma formation.
Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review
Authors: Seppälä Toni T , Burkhart Richard A , Katona Bryson W 
Published: May 2023

Abstract

Background
Inheritance patterns show familial clustering of gastrointestinal cancers, and multiple germline conditions have now been identified that predispose to colorectal, gastric, and pancreatic cancers.

Methods
A narrative review based on recent relevant literature was conducted.

Results
Lynch syndrome, formerly known as hereditary non-polyposis colorectal cancer, increases the risk of several abdominal cancers, with the highest population prevalence. Familial adenomatous polyposis and some of the more infrequent polyposis syndromes have distinct characteristics affecting various organ-specific cancer risks. Hereditary gastric and pancreatic cancer syndromes include those also causing colorectal cancer, while additional genetic disorders predisposing only to upper gastrointestinal malignancies have been recognized more recently. Diagnosing and managing hereditary cancer syndromes requires multidisciplinary expertise and may be best managed in tertiary centres, with a need to consider patient preference and ensure shared decision-making.

Conclusion
Several germline conditions predispose to colorectal, gastric, and pancreatic cancer, which inform identification, surveillance regimens, prevention, cascade screening, counselling, and surgical management. The authors describe developments in the hereditary origin of colorectal, gastric, and pancreatic cancer with current recommendations in surveillance and surgical management.
Human gene and microbial analyses in rectal cancer complete responses to radiotherapy
Authors: Sulit Arielle Kae , Wilson Kasmira , Pearson John , Silander Olin K , Sampurno Shienny , Michael Michael , Ramsay Robert , Heriot Alexander , Frizelle Frank , Purcell Rachel Violet 
Published: May 2023

AbstractBackgroundThe gold standard treatment for locally advanced rectal cancer is total mesorectal excision after preoperative chemoradiotherapy. Response to chemoradiotherapy varies, with some patients completely responding to the treatment and some failing to respond at all. Identifying biomarkers of response to chemoradiotherapy could allow patients to avoid unnecessary treatment-associated morbidity rate. While previous studies have attempted to identify such biomarkers, none have reached clinical utility, which may be due to heterogeneity of the cancer. In this study, potential human gene and microbial biomarkers were explored in a cohort of rectal cancer patients who underwent chemoradiotherapy.MethodsRNA sequencing was carried out on matched tumour and adjacent normal rectum biopsies from patients with rectal cancer with varying chemoradiotherapy responses treated between 2016 and 2019 at two institutions. Enriched genes and microbes from tumours of complete responders were compared with those from tumours of others with lesser response.ResultsIn 39 patients analysed, enriched gene sets in complete responders indicate involvement of immune responses, including immunoglobulin production, B cell activation and response to bacteria (adjusted P values &lt;0.050). Bacteria such as Ruminococcaceae bacterium and Bacteroides thetaiotaomicron were documented to be abundant in tumours of complete responders compared with all other patients (adjusted P value &lt;0.100).ConclusionThese results identify potential genetic and microbial biomarkers of response to chemoradiotherapy in rectal cancer, as well as suggesting a potential mechanism of complete response to chemoradiotherapy that may benefit further testing in the laboratory.
Eurocentrism in a YouTube video on the Jakarta–Bandung railway: a critical examination of discourse across race, gender, and class
Authors: Li Zhou , Liu Yuchen , Chen Shushu , Huang Jingxuan 
Published: May 2023

Abstract
In this article, we examine the YouTube channel Railways Explained and its video on the Jakarta–Bandung High-Speed Railway (JBHSR). By stressing tensions among China, Indonesia, and Japan surrounding the JBHSR project, the video, we argue, managed to divert the audience’s attention away from its Eurocentric representation to a socially constructed Asian drama. Drawing upon Foucauldian poststructuralism, we then demonstrate how the Asian drama, narrated through three forms of otherness—ideological (Japan/Indonesia vs. China); developmental (Japan/China vs. Indonesia); and a geopolitical imaginary (the West vs. Asia)—revealed the perpetuation of Eurocentric hegemony in the knowledge of science and technology.
Impact of Integrase Inhibitors on Cardiovascular Disease Events in People With Human Immunodeficiency Virus Starting Antiretroviral Therapy
Authors: Surial Bernard , Chammartin Frédérique , Damas José , Calmy Alexandra , Haerry David , Stöckle Marcel , Schmid Patrick , Bernasconi Enos , Fux Christoph A , Tarr Philip E , Günthard Huldrych F , Wandeler Gilles , Rauch Andri ,   the Swiss HIV Cohort Study, Abela I , Aebi-Popp K , Anagnostopoulos A , Battegay M , Bernasconi E , Braun D L , Bucher H C , Calmy A , Cavassini M , Ciuffi A , Dollenmaier G , Egger M , Elzi L , Fehr J , Fellay J , Furrer H , Fux C A , Günthard H F , Hachfeld A , Haerry D , Hasse B , Hirsch H H , Hoffmann M , Hösli I , Huber M , Jackson-Perry D , Kahlert C R , Kaiser L , Keiser O , Klimkait T , Kouyos R D , Kovari H , Kusejko K , Labhardt N , Leuzinger K , Martinez de Tejada B , Marzolini C , Metzner K J , Müller N , Nemeth J , Nicca D , Notter J , Paioni P , Pantaleo G , Perreau M , Rauch A , Salazar-Vizcaya L , Schmid P , Speck R , Stöckle M , Tarr P , Trkola A , Wandeler G , Weisser M , Yerly S 
Published: May 2023

Abstract

Background
Integrase strand transfer inhibitors (INSTIs) have been associated with an increased risk for cardiovascular disease (CVD) events. We investigated the impact of starting INSTI-based antiretroviral therapy (ART) on CVD events among treatment-naïve people with human immunodeficiency virus using a target trial framework, which reduces the potential for confounding and selection bias.

Methods
We included Swiss HIV Cohort Study participants who were ART-naïve after May 2008, when INSTIs became available in Switzerland. Individuals were categorized according to their first ART regimen (INSTI vs other ART) and were followed from ART start until the first of CVD event (myocardial infarction, stroke, or invasive cardiovascular procedure), loss to follow-up, death, or last cohort visit. We calculated hazard ratios and risk differences using pooled logistic regression models with inverse probability of treatment and censoring weights.

Results
Of 5362 participants (median age 38 years, 21% women, 15% of African origin), 1837 (34.3%) started INSTI-based ART, and 3525 (65.7%) started other ART. Within 4.9 years (interquartile range, 2.4–7.4), 116 CVD events occurred. Starting INSTI-based ART was not associated with an increased risk for CVD events (adjusted hazard ratio, 0.80; 95% confidence interval [CI], .46–1.39). Adjusted risk differences between individuals who started INSTIs and those who started other ART were −0.17% (95% CI, −.37 to .19) after 1 year, −0.61% (−1.54 to 0.22) after 5 years, and −0.71% (−2.16 to 0.94) after 8 years.

Conclusions
In this target trial emulation, we found no difference in short- or long-term risk for CVD events between treatment-naïve people with human immunodeficiency virus who started INSTI-based ART and those on other ART.