bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biventricular cardiac power reserve in heart failure with preserved ejection fraction
Authors: Alogna Alessio , Omar Massar , Popovic Dejana , Sorimachi Hidemi , Omote Kazunori , Reddy Yogesh N.V. , Pieske Burkert , Borlaug Barry A. 
Published: April 2023

ABSTRACTAimsCardiac and extracardiac abnormalities play important roles in heart failure with preserved ejection fraction (HFpEF). Biventricular cardiac power output (BCPO) quantifies the total rate of hydraulic work performed by both ventricles, suggesting that it may help to identify patients with HFpEF and more severe cardiac impairments to better individualize treatment.Methods and resultsPatients with HFpEF (n = 398) underwent comprehensive echocardiography and invasive cardiopulmonary exercise testing. Patients were categorized as low BCPO reserve (n = 199, < median of 1.57 W) or preserved BCPO reserve (n = 199). As compared to those with preserved BCPO reserve, those with low reserve were older and leaner, with more atrial fibrillation, higher N‐terminal pro‐B‐type natriuretic peptide levels, worse renal function, more impaired left ventricular (LV) global longitudinal strain, worse LV diastolic function and right ventricular longitudinal function. Cardiac filling pressures and pulmonary artery pressures at rest were higher in low BCPO reserve, but central pressures were similar during exercise to those with preserved BCPO reserve. Exertional systemic and pulmonary vascular resistances were higher and exercise capacity was more impaired in those with low BCPO reserve. Reduced BCPO reserve was associated with increased risk for the composite endpoint of heart failure hospitalization or death over 2.9 (interquartile range 0.9–4.5) years of follow‐up (hazard ratio 2.77, 95% confidence interval 1.73–4.42, p < 0.0001).ConclusionsInability to enhance BCPO during exercise is associated with more advanced HFpEF, increased systemic and pulmonary vascular resistance, reduced exercise capacity and increased adverse events in patients with HFpEF. Novel therapies that enhance biventricular reserve merit further investigation for patients with this phenotype.
The phenol efficient degradation using co‐culture coupled with enhanced electricity generation capability
Authors: Zhan Yue , Ma Yamei , Cai Ting , Gao Shengchao , Zhang Zhen , Gao Tianpeng , Liu Ying 
Published: April 2023

AbstractThe co‐culture of strain Citrobacter sp. RDC and Geobacter sulfurreducens PCA was used in this study and it was found that the co‐culture using 200 mg/L phenol as carbon source exhibited higher maximum current density than using the single strain RDC and G. sulfurreducens PCA, respectively. Meanwhile, the co‐culture was used to generate electricity by degrading phenol with the current density of 699.07 μA/cm2 by using 200 mg/L phenol as the sole carbon source, which was higher than that only using G. sulfurreducens PCA (236.20 μA/cm2). Especially, the degradation efficiency of 200 mg/L phenol by co‐culture can reach 55.16 % within 36 h being 4.16‐fold higher than the single strain G. sulfurreducens PCA. Furthermore, the component ratio of two strains was optimized for increasing electricity generation using 500 mg/L phenol as carbon source. The maximum current density was 501.54 μA/cm2 under the ratio of 3 : 1 for strain RDC to G. sulfurreducens PCA. These results highlight that phenol is good carbon source for co‐culture to produce electricity. The co‐culture system provides a promising application pathway for phenol degradation treatment coupled with electricity generation in the future.
Association of ictal aphasia with hypoperfusion in language areas in temporal lobe epilepsy patients
Authors: Damian Andrés , Legnani Mariana , Braga Patricia , Ferrando Rodolfo 
Published: April 2023

AbstractIctal clinical phenomenology, including aphasia, is usually associated with increased regional cerebral perfusion. We present an unusual pattern of ictal cerebral perfusion in three patients with pharmacoresistant, lesional temporal lobe epilepsy and ictal/postictal aphasia studied with prolonged video‐EEG, ictal, and interictal SPECT and MRI for pre‐surgical evaluation. Subtraction of ictal‐interictal SPECT images co‐registered with MRI (SISCOM) showed ictal hyperperfusion in the temporal epileptogenic area in all patients. In addition, hypoperfusion of Broca's area in one case, Wernicke's area in other patient, and both areas in the remaining one were observed. Ictal aphasia in these patients may be explained by functional inhibition of a primary language area, driven by the epileptogenic network. This pattern can contribute to understand the pathophysiology of some ictal signs, with an impact on the evaluation of individual surgical risks.
Role of EEG as a monitoring tool in patients with glucose transporter type I deficiency syndrome (GLUT1‐DS) on ketogenic diet
Authors: Toro‐Perez Juan , Healy Sarah , Sell Erick , Bulusu Srinivas , Whiting Sharon 
Published: April 2023

AbstractRationaleGlucose transporter type I deficiency syndrome (GLUT1‐DS) is the fourth most frequent single‐gene epilepsy refractory to standard antiepileptic drugs. Multiple seizure types and variable electrographic findings are reported. Ketogenic diet is expected to result in the complete resolution of the epileptiform activity.MethodsA retrospective chart review of patients with GLUT1‐DS on ketogenic diet between December 2012 and February 2022 was done. Analysis of the EEGs prior to and during the ketogenic diet was done.Results34 patients on ketogenic diet were reviewed. Ten had clinical diagnosis of GLUT1‐DS, and seven of them had genetic confirmation. 71% were female. The average age at seizure onset was 13.85 m.o. (range: 3–60, SD ±20.52), at diagnosis was 44.57 m.o (range: 19–79), and at the onset of ketogenic diet was 46.43 m.o. (range: 20–83). 29 months (range: 13–38) delay between symptoms onset until diagnosis was noticed. At the diagnosis 100% reported seizures: 71% myoclonic, 57% generalized motor, 57% absence, 28% atonic, and 14% focal motor. Also, 71% abnormal eye movements, 57% ataxia, and 28% intolerance to fasting. 86% had normal brain MRI. 71% had abnormal EEG. All were on ketogenic diet, and four on classical (1.75:1–2.25:1 ratio). Six were clinically seizure‐free after the ketogenic diet. EEG features included notch delta, focal spike and wave, and generalized spike/polyspike and wave. One patient had bilateral independent centrotemporal spikes. Spikes showed high and very high amplitude in all of them (>200 μV). The variation of the spike index decreased in three patients but increased in two.ConclusionKetogenic diet is the choice treatment for patients with GLUT1‐DS. Electrographic features could show worsening after initiation of the ketogenic diet even with seizure control. EEG did not prove to be a reliable tool for adjusting KD in our cohort. Centrotemporal spikes have not been reported in patients with GLUT‐1 DS.
Multifactor analysis of roof deformation and reasonable determination of the unsupported distance of a coal roadway heading face based on response surface method
Authors: Su Chao , Li Peng , Gong Peilin , Liu Chang 
Published: April 2023

AbstractThis paper is aimed at the problems of multiple factors influencing the roof stability near a heading face and unreasonable values of the unsupported distance leading to a slow excavation speed. The behavior of the direct roof subsidence in the unsupported area is analyzed, and numerical simulation and the response surface method are used to study the key factors affecting the roof deformation and their interaction relations. The results indicate that roof strength is the most critical factor affecting deformation and failure, followed by soft rock thickness, unsupported distance, and support strength. The interaction analysis in Zhaozhuang Coal Mine's 33082 lane shows that it is difficult to control the roof subsidence when the unsupported distance is more than 2 m and the soft rock thickness is more than 4 m. After the unsupported distance is set to about 2 m and the support strength is increased to 0.25 MPa, the excavation speed approximately doubles, and the overall roadway is stable and controllable. By implementing field applications, the rationality of the research approach was confirmed.
High‐performance flexible supercapacitor based on morphology tuned polypyrrole/molybdenum disulfide nanocomposites
Authors: Yadav Rimjhim , Saini Ayushi , Choudhary Jyoti , Sardana Silki , Ohlan Anil , Singh Kuldeep , Singh Surinder P. 
Published: April 2023

AbstractPolypyrrole (PPy) is the most studied material among the conducting polymers for high‐performance supercapacitors. However, due to morphology collapse, polypyrrole exhibits poor cycling ability and lower charge storage capacity, limiting its real‐world applications. To address these issues herein, the binary nanocomposites of PPy with MoS2 (molybdenum disulfide) NSs (nanostructures) in two different morphologies, that is, cenosphere (PPyC) and nanotubes (PPyNTs), have been prepared through in situ polymerization technique. The electrochemical performances of PPyC/MoS2 and PPyNTs/MoS2 nanocomposite are compared to define the most favorable morphology when PPy nanostructures are utilized as the electrode materials for creating flexible supercapacitors. The rational design of PPyNTs/MoS2 nanocomposite consisting of dense wrapping of PPyNTs on MoS2 leads to high specific capacitance (Csp) up to 481 F/g at 0.5 A/g. After 2000 charge‐discharge cycles, a decline of 5.6% in the specific capacitance of PPyNTs/MoS2 nanocomposite was observed, primarily attributed to the presence of chemically active sites on MoS2 nanosheets. This led to a strong alignment with the nitrogen group of pyrrole rings in the polymer chain to form a robust interconnected framework between tubular PPy and sheet‐like MoS2. This outstanding performance of PPyNTs/MoS2 nanocomposite resulted in designing futuristic flexible supercapacitors.
Perception and attitudes of street food vendors toward the healthiness of meals prepared and sold in Dodoma
Authors: Basheikh Zalia Omary , Jumbe Theresia , Kulwa Kissa 
Published: April 2023

AbstractConsumption of street meals among urban dwellers has become inevitable, especially in low‐ and middle‐income countries. It has been linked to higher incidence of dietary‐related diseases. Vendors' perceptions and attitudes toward the healthiness of meals can influence nutritional quality of the offered meals. Therefore, the study aimed to assess perceptions and attitudes of vendors toward healthy and unhealthy meals as well as the healthiness of meals they prepare and sell. A cross‐sectional study was carried out among 384 street food vendors. Face‐to‐face interviews were conducted using semistructured questionnaire. Pearson Chi‐square test and logistic regression analysis were used in comparing and testing for the association of perceptions and attitudes to vendors' characteristics. Street food vendors that took part in this study demonstrated good perceptions based on what they perceived to be healthy meals (58.33%) and positive attitudes (95.57%) toward preparation and provision of healthy meals. Perceptions were associated with sex (p = .007), education level (p = .002), and investment cost (p = .000). Results from logistic regression showed that better perceptions of healthy meals were associated with being female (OR = 2.46, p‐value < .031), having higher education (OR = 11.88, p‐value < .042), and vending experience of 1–5 years and more than 5 years (OR = 3.17, 2.95, p‐value < .019, .039, respectively) while having moderate investment cost showed significant lower chances of having better perceptions (OR = 0.33, p‐value < .001). Attitudes were associated with sex (p = .002), age (p = .002), marital status (p = .013), education (p = .009), and vending experience (p = .008). Female vendors, having 25 years of age and above, living with partners, with tertiary education, and having vending experience of more than 1 year had shown to have more positive attitudes toward healthy meals. Generally, street food vendors had good perceptions and attitudes toward healthy meals. This implies possible room for change and adoption of better ways of preparing meals. These findings could be used as a stepping stone in improving nutritional and healthy quality of street meals. Increased efforts are needed on the inclusion of nutritional aspects of healthy meals as they were merely considered by vendors. Future interventions on these vendors should focus more on male vendors, vendors with little vending experience, and little education as they had shown to have relatively poorer attitudes and perceptions compared to other groups.
Development of machine learning and multivariable models for predicting blood transfusion in head and neck microvascular reconstruction for risk‐stratified patient blood management
Authors: Puladi Behrus , Ooms Mark , Rieg Annette , Taubert Max , Rashad Ashkan , Hölzle Frank , Röhrig Rainer , Modabber Ali 
Published: April 2023

AbstractBackgroundAlthough blood transfusions have adverse consequences for microvascular head and neck reconstruction, they are frequently administered. Pre‐identifying patients would allow risk‐stratified patient blood management.MethodsDevelopment of machine learning (ML) and logistic regression (LR) models based on retrospective inclusion of 657 patients from 2011 to 2021. Internal validation and comparison with models from the literature by external validation. Development of a web application and a score chart.ResultsOur models achieved an area under the receiver operating characteristic curve (ROC‐AUC) of up to 0.825, significantly outperforming LR models from the literature. Preoperative hemoglobin, blood volume, duration of surgery and flap type/size were strong predictors.ConclusionsThe use of additional variables improves the prediction for blood transfusion, while models seems to have good generalizability due to surgical standardization and underlying physiological mechanism. The ML models developed showed comparable predictive performance to an LR model. However, ML models face legal hurdles, whereas score charts based on LR could be used after further validation.
Effectiveness of interventions to contain out‐of‐pocket‐expenditure in lower‐middle income countries: A systematic review and synthesis
Authors: Sugunan Aswin , Rajasekharan Pillai K , George Anice 
Published: April 2023

AbstractThe extant literature on myriad interventional strategies to contain the adverse financial impacts of soaring out‐of‐pocket expenditures commands systematic auditing and knowledge synthesis. The purpose of this study is to answer these specific questions. What are the interventions present in lower‐middle‐income countries? How effective are those interventions in reducing the household's out‐of‐pocket expenditure? Are the studies suffering from any methodological bias? The imprints for this systematic review are obtained from Scopus, PubMed, Web of Science, ProQuest and CINAHL. These manuscripts are identified in full compliance with PRISMA guidelines. The documents identified have undergone quality assessment checks using the ‘Effective Public Health Practice Project’. The review identified Interventions that are found to reduce out‐of‐pocket expenditure are patient educational programs, a combination of financial assistance, healthcare facility quality upgrade measures, and early disease detection strategies. However, these reductions represented marginal changes in the total health expenditure of patients. The role of non‐health insurance interventions and the combination of health insurance and non‐health insurance measures are highlighted. This review concludes by emphasising the need for further research to fill the knowledge gap by building on the suggestions put forward.
Flow resistance of flexible vegetation in real‐scale drainage channels
Authors: Nicosia Alessio , Carollo Francesco Giuseppe , Palmeri Vincenzo , Ferro Vito 
Published: April 2023

AbstractThe definition of simple and accurate methods to estimate flow resistance in vegetated channels is still a challenging issue in soil bioengineering practices and programming riparian vegetation management to control channel conveyance capacity, sediment deposition, and flooding propensity. In this paper, measurements collected by Errico et al. (2018, 2019) in drainage channels colonized by common reed (Phragmites australis) were used to study the effect of flexible vegetation and its management in flow resistance estimate. At first, a theoretical flow resistance equation, obtained applying dimensional analysis and incomplete self‐similarity condition for the velocity distribution of an open channel flow, was briefly summarized. Then, this flow resistance equation was calibrated and tested by open‐field hydraulic experiments carried out by Errico et al. (2018, 2019) at the real scale of existing vegetated drainage channels. In particular, the Γ function of the power velocity profile was empirically related to the slope energy and the flow Froude number by using the available measurements. Taking into account the hydrological regime of the flow in the investigated channels, the original data set was divided into two sub‐data sets (calibrating and testing data set) exploring the same range of measured discharges. The calibration and testing of the flow resistance equation were carried out without distinguishing measurements corresponding to different vegetation conditions (full‐vegetated, half‐vegetated, non‐vegetated, central vegetation cut, extensive vegetation cut). The analysis demonstrated that the theoretical flow resistance equation allows an accurate estimate of the Darcy‐Weisbach friction factor which is characterized by errors that are always less than 10% and less than or equal to 5% for 90.9% of the investigated cases. The finding of this study also allowed to evaluate the effects of different vegetation management scenarios on flow resistance.
A case of repeat oligoprogressive castration‐resistant prostate cancer treated with pulmonary metastasectomy
Authors: Soma Takahiko , Yoshida Soichiro , Wakejima Ryo , Taguchi Towako , Fukuda Shohei , Tanaka Hajime , Yokoyama Minato , Ohashi Kenichi , Okubo Kenichi , Fujii Yasuhisa 
Published: April 2023

IntroductionSeveral retrospective studies have demonstrated the efficacy of progressive site‐directed therapy for oligoprogressive castration‐resistant prostate cancer. However, eligible patients for progressive site‐directed therapy in these studies were limited to oligoprogressive castration‐resistant prostate cancer with bone or lymph node metastases without visceral metastases, and little is known about the efficacy of progressive site‐directed therapy for oligoprogressive castration‐resistant prostate cancer with visceral metastases.Case presentationWe report a case with castration‐resistant prostate cancer previously treated with enzalutamide and docetaxel, in which only a solitary lung metastasis was identified throughout the course of treatment. The patient underwent thoracoscopic pulmonary metastasectomy with a diagnosis of repeat oligoprogressive castration‐resistant prostate cancer. Only androgen deprivation therapy was continued and his prostate‐specific antigen levels remained undetectable for 9 months after surgery.ConclusionOur case suggests that progressive site‐directed therapy may be effective for carefully selected repeat OP‐CRPC with a lung metastasis.
Treatment of nail clippings with ethyl alcohol improves the efficacy of Raman spectroscopy in the diagnosis of Trichophyton rubrum onychomycosis
Authors: Petrokilidou Chrysoula , Gaitanis Georgios , Velegraki Aristea , Bassukas Ioannis D. , Kourkoumelis Nikolaos 
Published: April 2023

AbstractThe purpose of this work was to enhance the diagnostic accuracy of nail Raman spectroscopy for fungal nail infections, specifically onychomycosis caused by Trichophyton rubrum. The study assessed the different ethyl alcohol retention rates between control and infected nails after soaking nail clippings in ethanolic solutions and drying. Results revealed that ethyl alcohol completely evaporated from infected nail samples, while significant amounts were still present in control samples. Principal component analysis (PCA) was applied to discriminate control from infected nails and showed superior group separation when nails were treated with ethyl alcohol. PCA loadings plot attributed the efficient classification to the νs(CCO) Raman vibrational mode of ethyl alcohol. As Raman spectroscopy can detect minute concentration changes of ethyl alcohol in nails and the deterioration caused by onychomycosis accelerates its evaporation, a simple and rapid method for detecting T. rubrum onychomycosis is proposed.
Role of galectin‐3 in the elastic response of radial growth phase melanoma cancer cells
Authors: Herrera‐Reinoza Nataly , Tortelli Junior Tharcisio Citrangulo , Teixeira Fernanda de Sá , Chammas Roger , Salvadori Maria Cecília 
Published: April 2023

AbstractMelanoma is originated from the malignant transformation of the melanocytes and is characterized by a high rate of invasion, the more serious stage compromising deeper layers of the skin and eventually leading to the metastasis. A high mortality due to melanoma lesion persists because most of melanoma lesions are detected in advanced stages, which decreases the chances of survival. The identification of the principal mechanics implicated in the development and progression of melanoma is essential to devise new early diagnosis strategies. Cell mechanics is related with a lot of cellular functions and processes, for instance motility, differentiation, migration and invasion. In particular, the elastic modulus (Young's modulus) is a very explored parameter to describe the cell mechanical properties; most cancer cells reported in the literature smaller elasticity modulus. In this work, we show that the elastic modulus of melanoma cells lacking galectin‐3 is significantly lower than those of melanoma cells expressing galectin‐3. More interestingly, the gradient of elastic modulus in cells from the nuclear region towards the cell periphery is more pronounced in shGal3 cells.Research Highlights
AFM imaging and force spectroscopy were used to investigate the morphology and elasticity properties of healthy HaCaT cells and melanoma cells WM1366, with (shSCR) and without (shGal3) expression of galectin‐3.
It is shown the effect of galectin‐3 protein on the elastic properties of cells: the cells without expression of galectin‐3 presents lower elastic modulus.
By the results, we suggest here that galectin‐3 could be used as an effective biomarker of malignancy in both melanoma diagnostic and prognosis.