bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the EORTC information (QLQ-INFO25) and satisfaction with care (IN-PATSAT32) modules in Polish cancer patients’ population
Authors: Rudzińska Agnieszka , Kukla Patryk , Zygulska Aneta L. , Grela-Wojewoda Aleksandra , Pacholczak-Madej Renata , Gaweł Małgorzata , Zuchowska-Vogelgesang Beata , Streb-Smolen Anna , Mucha-Małecka Anna , Tomaszewska Iwona M. , Ziobro Marek , Püsküllüoğlu Mirosława 
Published: September 2023

Abstract

Background: The IN-PATSAT32 and QLQ-INFO25 are questionnaires which can be applied to assess and improve communication with cancer patients, as well as for research and clinical trials aimed at assessing patients’ satisfaction and perception of the information received from nurses and other healthcare providers. Given the recently passed “Polish oncological network” act of law, the issue of patient satisfaction and its regular assessment is finally acknowledged in the socioeconomic and cultural context of Poland. The aim of this study was to perform validation of EORTC satisfaction with care QLQ-INFO25 and quality of information IN-PATSAT32 modules.
Methods: The prospective cross-sectional study included patients from cancer reference center from Krakow, Poland. The translated and pilot-tested module QLQ-INFO25 was used together with core questionnaire QLQ-C30 and satisfaction module IN-PATSAT32. Adult patients with histological confirmation of any malignancy and ability to understand the questionnaire were included into the study.
Results: 187 patients were enrolled, including 111 women and 76 men (mean age ± SD; 59.32 ± 10.4). Cronbach's alpha coefficients, range 0.83-0.85 for QLQ-INFO25 and 0.82-0.94 for IN-PATSAT32 showed positive internal consistency. Acceptable convergent and discriminant validity in multi-trait scaling analyses was seen for both modules with r<0.3 for all calculations. Interclass correlations proved satisfactory test-retest reliability.
Conclusions: Polish versions of IN-PATSAT32 and QLQ-NFO25 are reliable and valid instruments providing domains not covered by core EORTC module. Tools are suitable for use in daily clinical practice, in research as well as in clinical trials in order to obtain data regarding patients’ perception of and satisfaction with received information within the socioeconomic and cultural context of Poland.
Event-triggered delay compensation control for networked systems with random delay
Authors: Zhang Ji 
Published: September 2023

Abstract
This paper aims to investigate the problem of event-triggered control for a networked system with two channels of random delays. First, a discrete-time event-triggered scheme, in which sensor information is only updated when it is necessary, is presented. Next, the system is modeled as a time-delay singular Markovian jump system with time-varying switching. Then, an event-triggered network-induced delay compensation strategy is proposed. Sufficient conditions guaranteeing the asymptotically stable are derived based on the Lyapunov-Krasovskii functional method together with the linear matrix inequality (LMI) technique. Finally, simulation results and a practical networked DC servo control system verify the effectiveness of the proposed strategy.
Relationship between Parkinson's disease and cardiovascular diseases: a Mendelian randomized study
Authors: Zhou Zhongzheng , Zhang Muzi , Fang Qinghua , Huang Jing 
Published: September 2023

Abstract
Background
Parkinson's disease (PD) and cardiovascular disease (CVDs) are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on CVDs using a Mendelian randomization (MR) method.
Methods
The data for PD were single nucleotide polymorphisms (SNPs) from a publicly available genome-wide association Study (GWAS) dataset containing data on 482,730 individuals. And the outcome SNPs data is from the GWAS database with a 17,891,936 sample size. The basic method for MR Analysis was the inverse variance weighted (IVW) approach. We use the weighted median method and the MR-Egger method to supplement the MR Analysis conclusion. Finally, We used Cochran's Q test to test heterogeneity, MR-PRESSO method and leave-one-out analysis method to perform sensitivity analysis.
Results
We used ratio ratios (OR) to assess the strength of the association between exposure and outcome, and 95% confidence intervals (CI) to show the reliability of the results. Our findings imply that PD is linked to a higher occurrence of coronary artery disease (CAD) (OR = 1.055, 95% CI: 1.020–1.091, P = 0.001 ), stroke (OR = 1.039, 95% CI: 1.007–1.072, P = 0.014 ). IVW analyses for Stroke's subgroups of ischemic stroke (IS) and cardioembolic stroke (CES) also yielded positive results, respectively (OR = 1.043, 95% CI: 1.008–1.079, P = 0.013 ), (OR = 1.076, 95% CI: 1.008–1.149, P = 0.026 ). There is no evidence of a relationship between PD and other CVDs. Additionally, sensitivity analysis revealed reliable outcomes.
Conclusion
Our MR study analysis that Parkinson's disease is related with an elevated risk of CAD, stroke, IS, and CES.
Disentangling organizational and economic levers in transitional care programs: A systematic review and configurational analysis
Authors: Landi Stefano , Panella Maria Martina , Leardini Chiara 
Published: September 2023

Abstract
Background
Promoting a safe and efficient transition of care is pivotal to reduce the readmission rate and related costs and improve the quality of patient care. A growing body of literature suggests that transitional care (TC) programs are effective in improving quality of life and reducing the number of unplanned readmissions for several groups of patients. TC programs are highly complex and multidimensional calling for new evidence on how specific practices influence their effectiveness in patient care and readmission reduction.
Methods
The study investigates, through a systematic review and a configurational approach, the roles played by system characteristics (size, ownership, professional skill, technology used), the components and the combination of components implemented, and the potential economic impact of transitional care programs.
Results
The more component are implemented, the higher the probability of a TC program successfully reducing readmission rates. Not all components have the same impact. The findings show that certain components are necessary: “Monitoring and Managing Symptoms after Discharge” and “Discharge Planning.” In settings where not all the components are feasible, the findings show two different combinations of component can achieve reduction in readmissions. Moreover, the study shows different ways to involve professionals’ skill mix and their mode of coordination in TC programs. Four organizational models emerge: the health-based monocentric, social-based monocentric, multidisciplinary team, and mono-specialist team.
Conclusions
The results underline the importance of examining in depth the role of organizational and economic factors in facilitating the creation of a successful TC program. The work gives preliminary insights into how to systematize management practices and different organization modes facilitating decision-makers’ choices in TC implementation.
Effects of Eight-Week Strength Training on Basal Hormone Levels, Oxidative Stress Markers and IL-6 Levels in Adolescent Athletes
Authors: Hayta Umit , Dınc Nurten , Taneli Fatma 
Published: September 2023

Abstract

Purpose This study investigated how strength training affects adolescent athletes' hormonal, cytokine, and oxidative stress markers.
Methods The participants were split into two groups: Strength training (ST) (n=10) and control (C) (n=10). The strength training group participated in 8-week handball and strength training. The Control group followed their weekly handball training routine. The ST group participated in traditional strength training 3 days a week in addition to handball training for 8 weeks. We quantified hormone, oxidative stress markers and IL-6 in the subject’s blood samples.
Result Interestingly Insulin-like growth factor-1 concentration declined in the C group (p<0.05), while the ST serum concentrations did not change statistically (p>0.05). Insulin-like growth factor binding protein-3 (IGFBP3) and sex hormone binding globulin (SHBG) concentration of the ST decreased but did not in C. Serum-free testosterone (FT) levels increased in both groups, while total testosterone levels did not change. While total antioxidant status (TAS) and antioxidants stress index (ASI) did not change, total oxidant status (TOS) and oxidative stress index (OSI) reduced both groups (p<0.05). Serum interleukin-6 (IL-6) levels did not alter ST and C groups.
Conclusion While strength training did not affect serum concentrations of testosterone, GH, IGF-1, Cortisol, IL-6, and total antioxidant status, it caused a decrease in SHBG and IGFBP3. Serum FT levels increased in ST and C groups. Also, serum TOS levels declined ST and C; it is unclear whether strength training affects the increase in free testosterone or the decrease in TOS levels.
The antagonistic activity of Streptomyces scopuliridis (No. HS1) against of poplar canker pathogen Botryosphaeria dothidea
Authors: Liu Qingzhen , Li Xin , Mao He , Zuo Tongtong , Zhang Yang , Gou Tianbing , Chen Jingsheng , Li Limei 
Published: September 2023

Abstract

Background Poplar canker caused by Botryosphaeria dothidea is one of the most severe plant disease that is also associated with death of poplars worldwide. In this study, the biocontrol efficacy and mechanisms of action of Streptomyces scopuliridis (No. HS1), which was previously isolated from soil, was determined against B. dothidea. In vitro, S. scopuliridis and fermentation broth supernatant (FBS) significantly suppressed mycelium growth and biomass accumulation and also disrupted the mycelium morphology of B. dothidea.
Results On the 3rd day after treatment, the inhibition rates of colony growth and dry weight were 80.72% and 52.53%, respectively. In addition, FBS treatment damaged the plasma membrane of B. dothidea based on increased electrical conductivity in the culture medium and malondialdehyde content in B. dothidea hyphae. Notably, analysis of key enzymes in glycolysis pathway showed that the activity of hexokinase, phosphofructokinase, and pyruvate kinase increased after FBS treatment. Moreover, the activity of Ca2+Mg2+-ATPase increased, which considerably affected the accumulation of nutrients and energy in pathogenic cells. Meanwhile, the significant reduction in glucose contents and increase in pyruvate contents in B. dothidea treated with FBS further confirmed that FBS may accelerate glycolysis in B. dothidea, which accelerated energy consumption and reduced nutrients accumulation r in B. dothidea.
Conclusions In summary, the inhibitory mechanism of FBS on B. dothidea was a complex process, which was reflected in multiple levels of mycelium growth, cell membrane structure, material and energy metabolism. Therefore, S. scopuliridis (No. HS1) FBS represents an ecofriendly biocontrol alternatives for poplar canker with good antifungal effect, which provides an alternative approach to biological control strategies.
Smart City Healthcare Delivery Innovations: A Systematic Review of Essential Technologies and Indicators for Developing Nations
Authors: Mohammadzadeh Zahra , Saeidnia Hamid Reza , Lotfata Aynaz , Hassanzadeh Mohammad 
Published: September 2023

Abstract
Background: In recent times, the concept of smart cities has gained remarkable traction globally, driven by the increasing interest in employing technology to address various urban challenges, particularly in the healthcare domain. Smart cities are proving to be transformative, utilizing an extensive array of technological tools and processes to improve healthcare accessibility, optimize patient outcomes, reduce costs, and enhance overall efficiency.
Methods: This article delves into the profound impact of smart cities on the healthcare landscape and discusses its potential implications for the future of healthcare delivery. Moreover, the study explores the necessary infrastructure required for developing countries to establish smart cities capable of providing intelligent health and care services. To ensure a comprehensive analysis, we employed a well-structured search strategy across esteemed databases, including PubMed, OVID, EMBASE, Web of Science, and Scopus. The search scope encompassed articles published up to November 2022, resulting in a meticulous review of 22 relevant articles.
Results: Our findings provide compelling evidence of the pivotal role that smart city technology plays in elevating healthcare delivery, forging a path towards improved accessibility, efficiency, and quality of care for communities worldwide. By harnessing the power of data analytics, Internet of Things (IoT) sensors, and mobile applications, smart cities are driving real-time health monitoring, early disease detection, and personalized treatment approaches.
Conclusion: Smart cities possess the transformative potential to reshape healthcare practices, providing developing nations with invaluable opportunities to establish intelligent and adaptable healthcare systems customized to their distinct requirements and limitations. Moreover, the implementation of smart healthcare systems in developing nations can lead to enhanced healthcare accessibility and affordability, as the integration of technology can optimize resource allocation and improve the overall efficiency of healthcare services. It also may help alleviate the burden on overburdened healthcare facilities by streamlining patient care processes and reducing wait times, ensuring that medical attention reaches those in need more swiftly.
A Symmetrical Arrangement Strategy based Real-time Toolpath Planning Method for A 5-DoF Fully Parallel Machining Robot
Authors: Wang Yifan , Xie Zenghui , Xie Fugui , Liu Xin-Jun 
Published: September 2023

Abstract

A 5-DoF fully parallel machining robot (PMR) with attitude coupling motion property has the potential to realize the high-efficiency and high-quality machining of complex parts with curved surfaces. From the perspective of mechanism, this kind of 5-DoF fully PMR can achieve no singularity in the workspace after optimum design, so the mobile platform can be adjusted to an arbitrary orientation directly and flexibly. In order to give full play to the above mechanical characteristics, the idea of planning orientation path in unit spherical coordinate system was proposed in our previous work, and then the orientation adjustment efficiency was improved. But the toolpath continuity and calculation simplicity remain to be solved. In light of this concern, the constraint equations to ensure the continuity between two adjacent B-splines are established, and the configuration of control points that can ensure the controllable curvature is derived. On this basis, a symmetrical arrangement strategy that generates shape limits for fitted B-splines to achieve high-order continuity is proposed, and a toolpath planning method is established accordingly. To reduce computational complexity in the feedrate scheduling stage, a linear constraints system is adopted to calculate the feedrate of each point, and the feedrate calculation and interpolation are conducted simultaneously to generate the motion trajectory in real-time. The trajectory planning of S-shaped toolpaths is conducted using the proposed method and the commercial ISG CNC kernel respectively. The comparison results show that the proposed method can effectively improve the motion efficiency, the complexity of calculation, and the fluctuation of feedrate and acceleration. This study provides a more efficient and effective trajectory planning method and is of great significance to the further development of the 5-DoF PMR.
Surface-Enhanced Raman Spectroscopy in Urinalysis of Hypertension Patients with Kidney Disease
Authors: Espinosa-Garavito Alberto C. , Quiroz Elkin Navarro , Galán-Freyle Nataly J. , Méndez-López Maximiliano , Aroca-Martinez Gustavo , Gomez-Escorcia Lorena , Acosta-Hoyos Antonio , Pacheco-Lugo Lisandro , Espitia-Almeida Fabián , Hernández-Rivera Samuel P. , Villa-Medina Joe , Pacheco-Londoño Leonardo C. 
Published: September 2023

Abstract
Arterial hypertension (AH) is a multifactorial and asymptomatic disease that affects vital organs such as the kidneys and heart. Considering its prevalence and the associated severe health repercussions, hypertension has become a disease of great relevance for public health across the globe. Conventionally, the classification of an individual as hypertensive or nonhypertensive is conducted through ambulatory blood pressure monitoring over a 24-h period. Although this method provides a reliable diagnosis, it has notable limitations, such as additional costs, intolerance experienced by some patients, and interferences derived from physical activities. Moreover, some patients with significant renal impairment may not present proteinuria. Accordingly, alternative methodologies are applied for the classification of individuals as hypertensive or nonhypertensive, such as the detection of metabolites in urine samples through liquid chromatography or mass spectrometry. However, the high cost of these techniques limits their applicability for clinical use. Consequently, an alternative methodology was developed for the detection of molecular patterns in urine collected from hypertension patients. In this study, a direct discrimination model for hypertensive and nonhypertensive individuals was generated through the amplification of Raman signals in urine samples based on gold nanoparticles and supported by chemometric techniques such as partial least squares-discriminant analysis (PLS-DA). Specifically, 162 patient urine samples were used to create a PLS-DA model. These samples included 87 urine samples from patients diagnosed with hypertension and 75 samples from nonhypertensive volunteers. The PLS-DA model with 4 latent variables (LV) was used to classify the hypertensive patients with a calibration sensitivity (SenCal) of 89.2%, cross-validation sensitivity (SenCV) of 75.4%, prediction sensitivity (SenPred) of 86.4%, calibration specificity (SpeCal) of 86.0%, cross-validation specificity (SpeCV) of 77.2%, prediction specificity (SpePred) of 77.8%, calibration accuracy (AccCal) of 87.7%, cross-validation accuracy (AccCV) of 77.0%, and prediction accuracy (AccPred) of 82.5%. This study demonstrates the ability of surface-enhanced Raman spectroscopy to differentiate between hypertensive and nonhypertensive patients through urine samples, representing a significant advance in the detection and management of AH.
Mediation effect of antithrombin III between chronic renal insufficiency and coronary artery disease in T2DM patients
Authors: Sun Ruoyu , Wang Shaohua , Wang Zheng , Wang Chenchen , Xu Yanchao , Yuan Yang 
Published: September 2023

Abstract
Purpose:The study aimed to investigate the potential effect of Antithrombin Ⅲ between chronic renal insufficiency and coronary artery disease in T2DM patients.
Methods:We collected data of T2DM patients hospitalized in ZhongDa Hospital affiliated with Southeast University. Relationships between renal function, Antithrombin Ⅲ, and coronary artery disease were explored using multivariate regression models. Multiplicative and additive interaction analysis was investigated. Bootstrap mediation analysis was utilized to investigate the role of Antithrombin Ⅲ.
Results:A total of 4,238 patients were included, among which the coronary artery disease prevalence was 23.8%. Lower levels of renal function and Antithrombin Ⅲ were observed in patients with coronary artery disease (P<0.05). In adjusted models, each 10-unit increase in Antithrombin Ⅲ was associated with an 8.3% (95%CI: 3.2%~13.1%; P<0.05) decrease in coronary artery disease risk. Patients with low levels of both eGFR and Antithrombin Ⅲ were in the highest risk (OR=1.45; 95%CI: 1.10-1.90, P<0.05) of coronary artery disease, while no multiplicative and additive interaction effects were significant. Bootstrap mediation analysis estimated that Antithrombin Ⅲ mediated approximately 4.40% of the effect of chronic renal insufficiency on coronary artery disease risk.
Conclusion:Antithrombin Ⅲ may serve as a mediator between chronic renal insufficiency and coronary artery disease, providing mechanistic insights into a new clinical observation.
Au@109Pd core-shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers. Studies on the applicability of 109Pd/109mAg in vivo generator in combined β−Auger electron therapy
Authors: Gharibkandi Nasrin Abbasi , Wawrowicz Kamil , Majkowska-Pilip Agnieszka , Żelechowska-Matysiak Kinga , Wierzbicki Mateusz , Bilewicz Aleksander 
Published: September 2023

Abstract
Background:
In radionuclide therapy, to enhance therapeutic efficacy, an intriguing alternative is to ensure the simultaneous implementation of low- and high-LET radiation emitted from a one radionuclide. In the present study, we introduce the concept of utilizing 109Pd (T1/2=13.7 h) in the form of a 109Pd/109mAg in vivo generator. In this system, 109Pd emits beta particles of medium energy, while 109mAg releases a cascade of conversion and Auger electrons. 109Pd was utilized in the form of 15nm gold nanoparticles, which were coated with a monolayer of 109Pd. In this system, the 109Pd atoms are on the surface of the nanoparticle, while the 109mAg atoms generated in the decay reaction possess the capability for unhindered emission of Auger electrons.
Results:
109Pd, obtained through neutron irradiation of natural palladium, was deposited onto 15-nm gold nanoparticles, exceeding a efficiency rate of 95%. In contrast to previously published data on in vivo generators based on chelators, where the daughter radionuclide diffuses away from the molecules, daughter radionuclide 109mAg remains on the surface of gold nanoparticles after the decay of 109Pd. To obtain a radiobioconjugate with an affinity for HER2 receptors, polyethylene glycol chains and the monoclonal antibody trastuzumab were attached to the Au@Pd nanoparticles. The synthesized bioconjugate contained an average of 9.5 trastuzumab molecules per one nanoparticle. In vitro cell studies indicated specific binding of the Au@109Pd-PEG-trastuzumab radiobioconjugate to the HER2 receptor on SKOV-3 cells, resulting in 90% internalization. Confocal images illustrated the accumulation of Au@109Pd-PEG-trastuzumab in the perinuclear area surrounding the cell nucleus. Despite the lack of nuclear localization, which is necessary to achieve an effective cytotoxic effect of Auger electrons, a substantial cytotoxic effect, significantly greater than that of pure β- and pure Auger electron emitters was observed. We hypothesize that in the studied system, the cytotoxic effect of the Auger electrons could have also occurred through the damage to the cell's nuclear membrane by Auger electrons emitted from nanoparticles accumulated in the perinuclear area.
Conclusion:
The obtained results show that trastuzumab-functionalized 109Pd-labeled nanoparticles can be suitable for the application in combined β− - Auger electron targeted radionuclide therapy. Due to both components decay (β− and conversion/Auger electrons), the 109Pd/109mAg in vivo generator presents unique potential in this field. Despite the lack of nuclear localization, which is highly required for efficient Auger electron therapy, an adequate cytotoxic effect was attained.