bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local prediction pools
Authors: Oelrich Oscar , Villani Mattias , Ankargren Sebastian 
Published: September 2023

AbstractWe propose local prediction pools as a method for combining the predictive distributions of a set of experts conditional on a set of variables believed to be related to the predictive accuracy of the experts. This is done in a two‐step process where we first estimate the conditional predictive accuracy of each expert given a vector of covariates—or pooling variables—and then combine the predictive distributions of the experts conditional on this local predictive accuracy. To estimate the local predictive accuracy of each expert, we introduce the simple, fast, and interpretable caliper method. Expert pooling weights from the local prediction pool approaches the equal weight solution whenever there is little data on local predictive performance, making the pools robust and adaptive. We also propose a local version of the widely used optimal prediction pools. Local prediction pools are shown to outperform the widely used optimal linear pools in a macroeconomic forecasting evaluation and in predicting daily bike usage for a bike rental company.
Functional, cognitive, and cerebrovascular aspects of depression before coronary artery bypass graft surgery: Testing the vascular depression hypothesis
Authors: Choi Joy J. , Kukla Bennett , Walsh Patrick , Oldham Mark A. , Lee H. Benjamin 
Published: September 2023

AbstractObjectiveDepression in patients undergoing coronary artery graft bypass (CABG) surgery is associated with morbidity and mortality, making its early identification and clinical management crucial. Vasculopathy and older age, hallmarks of patients requiring CABG, are also features of vascular depression. In this study, we assess for features of vascular depression in patients undergoing CABG surgery.MethodsThis is a cross‐sectional analysis of a single‐site prospective observational cohort study of patients undergoing CABG surgery. Subjects were assessed preoperatively using the Depression Interview and Structured Hamilton (DISH), depression scales, transcranial Doppler, neuropsychological testing, and clinical dementia rating (CDR).ResultsOf 161 subjects (mean age 66.2 ± 9.3, female 25%) who completed DISH, 18 had major or minor depression, 17 of whom had a past history of major or minor depression (mean age of onset 35.8 years‐old). Pre‐CABG depression was associated with greater functional impairment on CDR Sum of Boxes (OR = 3.7, 95% CI: 1.4, 9.7) and worse performance on letter fluency test (OR = 0.90, 95% CI: 0.81, 0.99) and trail‐making tests (A: OR = 1.06, 95% CI: 1.01, 1.12; B: OR 1.02, 95% CI: 1.01, 1.04). Pre‐CABG depression was not associated with middle cerebral artery (MCA) stenosis.ConclusionsPre‐CABG depression is associated with cognitive and functional impairment similar to vascular depression, but we did not find evidence of an association with older age of onset and MCA stenosis. Further studies on white matter disease in this population are needed to examine the vascular depression hypothesis for pre‐CABG depression.
Both stronger and weaker cerebro‐cerebellar functional connectivity patterns during processing of spoken sentences in autism spectrum disorder
Authors: Alho Jussi , Samuelsson John G. , Khan Sheraz , Mamashli Fahimeh , Bharadwaj Hari , Losh Ainsley , McGuiggan Nicole M. , Graham Steven , Nayal Zein , Perrachione Tyler K. , Joseph Robert M. , Stoodley Catherine J. , Hämäläinen Matti S. , Kenet Tal 
Published: September 2023

AbstractCerebellar differences have long been documented in autism spectrum disorder (ASD), yet the extent to which such differences might impact language processing in ASD remains unknown. To investigate this, we recorded brain activity with magnetoencephalography (MEG) while ASD and age‐matched typically developing (TD) children passively processed spoken meaningful English and meaningless Jabberwocky sentences. Using a novel source localization approach that allows higher resolution MEG source localization of cerebellar activity, we found that, unlike TD children, ASD children showed no difference between evoked responses to meaningful versus meaningless sentences in right cerebellar lobule VI. ASD children also had atypically weak functional connectivity in the meaningful versus meaningless speech condition between right cerebellar lobule VI and several left‐hemisphere sensorimotor and language regions in later time windows. In contrast, ASD children had atypically strong functional connectivity for in the meaningful versus meaningless speech condition between right cerebellar lobule VI and primary auditory cortical areas in an earlier time window. The atypical functional connectivity patterns in ASD correlated with ASD severity and the ability to inhibit involuntary attention. These findings align with a model where cerebro‐cerebellar speech processing mechanisms in ASD are impacted by aberrant stimulus‐driven attention, which could result from atypical temporal information and predictions of auditory sensory events by right cerebellar lobule VI.
Calix[8]arene‐Based Manganese Complexes for Electrocatalytic CO2 Reduction
Authors: Berlanga‐Vázquez Armando , Castillo Ivan 
Published: September 2023

AbstractTransition metal catalysts with modified second‐coordination sphere employed in the electrocatalytic CO2 can result in increased activity or directed product selectivity. Calixarenes can form metal complexes and potentially catalyze reactions within its cavity, taking advantage of the surrounding phenols groups to tune the reactivity by second‐coordination sphere effects. Here, we present a Mn(I) bromotricarbonyl complex with phenanthroline‐functionalized calix[8]arene ligands capable of electrocatalytically reducing CO2 into different products with 2,2,2‐trifluoroethanol as proton donor. The selectivity of the reaction seems to be affected by the calixarene cavity: two calixarene‐free analogous complexes reduce CO2 to CO almost exclusively, while the calixarene complexes produce primarily CO, H2. Interestingly, in some cases the less frequently observed CH4 was also detected, albeit with low Faradaic efficiency. Thus, the manganese center placed within the calixarene cavity promotes the formation of reduced CO2 products by more than two electrons and two protons, affording CH4 in some cases.
Extrauterine adenomyoma: A case report and systematic review of the literature
Authors: Giorgi Matteo , Labanca Luca , Centini Gabriele , Lazzeri Lucia , Martire Francesco Giuseppe , Sorrentino Ester , Mancini Virginia , Raimondo Diego , Raffone Antonio , Neola Daniele , Aru Anna Chiara , Habib Nassir , Casadio Paolo , Seracchioli Renato , Zupi Errico 
Published: September 2023

AbstractObjectiveTo describe a case of extrauterine adenomyoma (EA) and review all the cases of EA in the literature.MethodsPubmed/MEDLINE, Embase, and Google Scholar from 1807 to December 2022. All studies reporting the histologic diagnosis of an EA. We collected the following data: patient's age, size and location of adenomyoma, presence of endometriosis and adenomyosis, past gynecologic treatment, symptoms, diagnostic imaging, surgical intervention, alternative/adjuvant treatment, associated malignancy, and follow up.ResultsSixty‐seven studies with 85 patients were included. Pain was the most frequent symptom (69.5%). Among diagnostic examinations, ultrasonography was used in 60 out of 81 reported cases, with several radiologic features described. EA was located inside the pelvis in 77.6% of patients. Adnexa were the most frequent site of the disease (24, 28.2%). History of endometriosis or adenomyosis was described in 35 patients (35, 41.2%). Uterine tissue morcellation was reported in 6 of the 85 patients (7.1%). Associated malignancy was detected in 9 out of 85 patients with available data (10.6%). There were two recurrences of disease.ConclusionSpecific imaging features of EA are yet to be described in the literature. History of endometriosis and adenomyosis or uterine tissue morcellation may be suggestive of EA. Histologic examination can give a definitive diagnosis and exclude malignant transformation.
Association of overweight and obesity with cumulative live birth rates according to women's age: A cohort study of 26 567 treatment cycles
Authors: Cai He , Xue Xia , Liu Xiaohua , Bai Haiyan , Shi Juanzi 
Published: September 2023

AbstractObjectiveTo evaluate the effect of age on the association between maternal body mass index (BMI) and cumulative live birth rates (CLBRs) following in vitro fertilization treatment.MethodWe retrospectively analyzed the data of 26 567 women undergoing in vitro fertilization/intracytoplasmic sperm injection from 2016 to 2019. We conducted multivariate regression analysis of the association between CLBRs and maternal BMI and age category.ResultsA total of 16 626 (62.58%) patients achieved a live birth. Women with obesity had significantly decreased CLBRs compared with women who had normal weight (odds ratio [OR] 0.73 [95% confidence interval (CI), 0.66–0.80]). The significant interaction between age and BMI suggested that the impact of BMI on CLBRs was moderated by women's age (P interaction <0.001). The association between obesity and CLBRs was inverse among women aged <30 years (OR, 0.63 [95% CI, 0.54–0.73]), 30 to 34 years (OR, 0.79 [95% CI, 0.67–0.93]), and 35 to 37 years (OR, 0.71 [95% CI, 0.52–0.98]); however, decreases in CLBRs with obesity were not observed in women aged 38 to 40 years (OR, 1.17 [95% CI, 0.70–1.94]) and ≥ 41 years (OR, 1.25 [95% CI, 0.53–2.96]).ConclusionMaternal obesity was significantly associated with a lower likelihood of having a live birth, but the risk differed according to women's age. A higher BMI might have a less‐pronounced detrimental effect with increasing age.
An in situ self‐assembled peptide derivative for inhibition of glutathione synthesis and selective enhancement of tumor radiotherapy
Authors: Gong Xinyan , Cui Benhang , Li Paiyun , Gao Jie , Gao Yang , Cai Xiaoyao , Wang Hang , Zhang Wenxue , Yang Cuihong 
Published: September 2023

AbstractBackgroundInhibition of glutathione (GSH) synthesis in cancer cells considerably improves the efficacy of reactive oxygen species (ROS)‐related tumor therapy. Self‐assembled peptide derivatives can facilitate the efficient delivery and accumulation of small molecular drugs in cancer cells.MethodsSelf‐assembling modules were covalently linked to the GSH‐biosynthesis inhibitor l‐buthionine sulfoximine (BSO) by solid‐phase synthesis to form the self‐assembling peptide derivative Nap‐DFDFpY‐GG‐BSO (Nano‐BSO@ in situ). Subsequently, its enzyme‐instructed self‐assembly in vitro and on cell surfaces were confirmed, and its intracellular GSH depletion and radiotherapy‐sensitizing effects were determined.ResultsNano‐BSO@ in situ successfully self‐assembles into a hydrogel with a nanofibrous microstructure upon incubation with alkaline phosphatase (ALP) at a critical concentration of 9.84 μM. Furthermore, it selectively self‐assembles in situ on HeLa cells with high ALP expression. At a concentration of 50 μM, Nano‐BSO@ in situ decreases intracellular GSH levels by 80%, ∼2.3 times more than free BSO. Meanwhile, pretreatment of HeLa cells with 50 μM Nano‐BSO@ in situ for 24 h results in a radiotherapy sensitization enhancement ratio to γ‐rays of 2.09.ConclusionsA novel in situ self‐assembling peptide derivative for GSH depletion and selective enhancement of tumor radiotherapy was constructed. The excellent GSH‐depletion ability and remarkable radiotherapy‐enhancement performance indicate that Nano‐BSO@ in situ is a promising selective sensitizer for ROS‐related treatment of tumor cells with high ALP expression.
A scoping review of clinical pharmacist and pharmacy technician contributions to cystic fibrosis care
Authors: Kim Alexander S. , Thompson Amy N. , Axon David R. , Sabourin Ashley , Davies Madeleine J. , Shannon Carol , Nasr Samya Z. , Phan Hanna 
Published: September 2023

AbstractThe purpose of this scoping literature review was to assess available published literature/abstracts, and to examine described contributions by pharmacists and/or pharmacy technicians as part of the care of people with cystic fibrosis (pwCF). This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses Extension for Scoping Reviews (PRISMA‐ScR). Published abstracts and articles from inception through December 2022 were included if they described care of pwCF (all ages), with at least one group of participants receiving care/services from pharmacy staff, and were available in English. Data extractions were outcomes, study, and participant characteristics. From 756 abstracts and papers, 91 were included. The majority were published abstracts (n = 67), from the United States (n = 64), retrospective cohort study design (n = 47), involved pharmacist intervention (n = 75), with no comparison group (n = 48), and in an outpatient/ambulatory setting (n = 59). Most often, literature were descriptions of specific pharmacist services, evaluations of adding a pharmacist, or descriptions of overall pharmacist practice/role. Specific pharmacist services were defined as patient or caregiver education, adherence support, medication reconciliation, management of pulmonary exacerbations, and medication management (including monitoring, and telehealth). Pharmacists and pharmacy technicians have contributed to the care of pwCF in various ways; however, much of the available data are currently disseminated in the form of conference abstracts. Efforts to support author publication of data as full peer‐reviewed publications should be prioritized as this data can help support others’ efforts to develop or support similar clinical pharmacy services.
Facile fabrication of an extended‐release tablet of Ticagrelor using three dimensional printing technology
Authors: Rastpeiman Sama , Panahi Zahra , Akrami Mohammad , Haririan Ismaeil , Asadi Maryam 
Published: September 2023

AbstractThe objective of the study was to fabricate tailored extended‐release tablets of blood thinner Ticagrelor as once‐daily dosing using additive manufacturing for better compliance in heart failure therapy. The solid work design of the tablet was printed using hot melt extrusion (HME) based 3D printing by optimized mixture of Eudragit RS‐100, plasticizer and drug for producing extrudable and printable filaments. FTIR and TGA results showed no covalent interaction among ingredients and no decomposition during HME process, respectively. Friability, weight variation, assay and content uniformity tests met USP requirements, while the mean hardness of the tablets was calculated in a value between 40 and 50 kg. According to DSC and XRD results, the crystallinity state of the Ticagrelor was converted to an amorphous one in the tablet matrix. Smooth surfaces with multiple deposited layers were observed using SEM. In comparison, the maximum Ticagrelor release of 100% after 120 min from Brilinta® tablets was decreased to 97% in 400 min from the 3D tablet at infill of 90%. Korsmeyer‐Peppas kinetic model showed the drug release mechanism is affected by diffusion and swelling. In general, fabrication of the extended‐release 3D printed tablet of Ticagrelor using HME‐based‐additive manufacturing has the potential to provide specific doses with tailored kinetic release for personalized medicine, improving adherence at point‐of‐care.
Long‐term outcomes in a 25‐year‐old female affected with lipin‐1 deficiency
Authors: Stepien Karolina M. , Schmidt Wolfgang M. , Bittner Reginald E. , O'Toole Orna , McNamara Brian , Treacy Eileen P. 
Published: September 2023

AbstractLipin‐1 is a phosphatidic acid phosphohydrolase (EC 3.1.3.4) that catalyzes the dephosphorylation of phosphatidic acid to diacylglycerol and inorganic phosphate. Deficiency of this enzyme causes potentially fatal severe, recurrent episodes of rhabdomyolysis triggered by infection. The defect has only recently been recognized so little is known about the long‐term outcome in adult patients with this disorder. We report the course and outcome of a 25‐year‐old female patient with lipin‐1 deficiency after a recent episode of rhabdomyolysis requiring intensive care admission with a peak creatine kinase of 500 000 IU/L. One‐year post discharge from intensive care, the patient has residual drop foot bilaterally consistent with bilateral common peroneal neuropathies in addition to a background residual distal myopathy.
Working memory performance in glioma patients is associated with functional connectivity between the right dorsolateral prefrontal cortex and default mode network
Authors: Smolders Lars , De Baene Wouter , van der Hofstad Remco , Florack Luc , Rutten Geert‐Jan 
Published: September 2023

AbstractIn healthy subjects, activity in the default mode network (DMN) and the frontoparietal network (FPN) has consistently been associated with working memory (WM). In particular, the dorsolateral prefrontal cortex (DLPFC) is important for WM. The functional–anatomical basis of WM impairment in glioma patients is, however, still poorly understood. We investigated whether WM performance of glioma patients is reflected in resting‐state functional connectivity (FC) between the DMN and FPN, additionally focusing on the DLPFC. Resting‐state functional MRI data were acquired from 45 glioma patients prior to surgery. WM performance was derived from a pre‐operative N‐back task. Scans were parcellated into ROIs using both the Gordon and Yeo atlas. FC was calculated as the average Pearson correlation between functional time series. The FC between right DLPFC and DMN was inversely related to WM performance for both the Gordon and Yeo atlas (p = .010). No association was found for FC between left DLPFC and DMN, nor between the whole FPN and DMN. The results are robust and not dependent on atlas choice or tumor location, as they hold for both the Gordon and Yeo atlases, and independently of location variables. Our findings show that WM performance of glioma patients can be quantified in terms of interactions between regions and large‐scale networks that can be measured with resting‐state fMRI. These group‐based results are a necessary step toward development of biomarkers for clinical management of glioma patients, and provide additional evidence that global disruption of the DMN relates to cognitive impairment in glioma patients.
Electrophoretically deposited sulfonated poly(styrene‐co‐divinylbenzene) on a screw for microextraction of cationic dyes from aqueous solutions
Authors: Osooli Payam , Yamini Yadollah , Tabibpour Mahmoud , Nasrollahi Seyedeh Sara , Nikfarjam Nasser 
Published: September 2023

In the present work, a novel solid‐phase microextraction on a screw (MES) was employed to extract cationic dyes (malachite green, methylene blue, and rhodamine B) from food samples and fish breeding pool water. The sulfonated poly(styrene‐co‐divinylbenzene) was electrophoretically deposited on the surface of the grooves of a screw. Then the screw was placed inside a silicon tube as a holder to create a channel to run a test solution through it. The extracted dyes on the coated screw were eluted by a suitable eluent. High‐performance liquid chromatography with an ultraviolet/visible detector was utilized for the separation and analysis of the analytes. The effective parameters of the analyte extraction efficiency were optimized. Under optimum conditions, the limits of detection were 0.15 μg/L, and calibration curves were linear in the range of 0.50–250.00 μg/L, with coefficients of determination > 0.989 for all studied dyes. The relative standard deviations of intra and inter‐day (n = 3) were in the range of 2.8%–7.0% and 7.0%–9.5%, respectively. The MES was applied as a simple and repeatable method with acceptable relative recoveries (82.0%–103.0%) for the determination of cationic dyes in grape nectar, ice pop, jelly powder, and fish breeding pool water.
Local‐scale abiotic factors influence the organization of rock pool arthropod communities in a biodiversity hotspot
Authors: Kulkarni Mihir R. , Paripatyadar Shruti V. , Naniwadekar Rohit , Joshi Jahnavi 
Published: September 2023

AbstractDetermining drivers of community assembly is central to ecology, and patchily distributed temporary habitats offer an ideal system to study the roles of ecological and evolutionary processes in structuring communities over different spatial scales. We studied functionally diverse arthropod communities in 32 freshwater rock pools on 3 plateaus in the Western Ghats biodiversity hotspot, sampling them throughout their hydroperiod (2–7 months). Using the Hierarchical Modeling of Species Communities approach, we assessed (a) the influence of local (water chemistry, habitat complexity at the pool level) and regional (seasonality in temperature and precipitation at the plateau level) scale abiotic covariates in shaping species' occurrence, (b) the influence of species traits (dispersal/reproductive mode, body size, feeding guild) and phylogenetic relationships on species response to abiotic covariates, and (c) the strength of biotic filtering in the communities. Environmental filtering was the dominant driver of community structure, where the pool‐level covariates (mainly hydroperiod and water chemistry), explained greater variation (56.3%) in species occurrences rather than plateau‐level covariates, that is, climatic seasonality (33.7%). Spatial factors explained only 11% of the variation in species occurrences. The selected traits explained 22% variation in species' responses, with body size responding to the abiotic covariates at both spatial scales. Closely related taxa exhibited shared responses to the abiotic covariates. Only a few residual associations were observed, all among passive dispersers, indicating a low contribution of biotic filtering to community structure. Our results highlight the importance of habitat‐level factors and the key role of evolutionary processes in shaping diversity in this vulnerable landscape characterized by its seasonality.
Analog Programmable‐Photonic Computation
Authors: Macho‐Ortiz Andrés , Pérez‐López Daniel , Azaña José , Capmany José 
Published: September 2023

AbstractDigital electronics is a technological cornerstone in this modern society that has covered the increasing demand for computing power during the last decades thanks to a periodic doubling of transistor density in integrated circuits. Currently, such scaling law is reaching its fundamental limit, leading to the emergence of a large gamut of applications that cannot be supported by digital electronics, specifically, those that involve real‐time multi‐data processing, e.g., medical diagnostic imaging, robotic control, and autonomous driving, among others. In this scenario, an analog computing approach implemented in a real‐time reconfigurable nonelectronic hardware such as programmable integrated photonics (PIP) can be more efficient than digital electronics to perform these emerging applications. However, actual analog computing models such as quantum and neuromorphic computation were not conceived to extract the unique benefits of PIP (and integrated photonics in general). Here, the foundations of a new computation theory are presented, termed Analog Programmable‐Photonic Computation (APC), explicitly designed to unleash the full potential of PIP technology. Interestingly, APC enables overcoming basic theoretical and technological limitations of existing computational models and can be implemented in other technologies (e.g., in electronics, acoustics or using metamaterials), consequently exhibiting the potential to spark a ground‐breaking impact on the information society.