bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It's wrong to relax, you have to be on the go, go, go, all the time”: Emotional transformation in a case of emotion‐focused therapy for generalised anxiety disorder
Authors: Keogh Daragh , Timulak Ladislav 
Published: September 2023

AbstractGeneralised anxiety disorder (GAD) is a highly prevalent, chronic and impairing disorder. The aim of this study was to qualitatively describe the transformation in emotional processing across 16 sessions of a successful emotion‐focused therapy (EFT) treatment for GAD. A theoretical framework derived from the EFT model of in‐session emotional transformation proposed by Pascual‐Leone and Greenberg was used as the basis for qualitative analysis. Additionally, the Classification of Affective Meaning States, the Client‐Expressed Arousal Scale‐III and the Client Emotional Productivity Scale‐Revised were utilised by observer–raters to classify moment‐by‐moment shifts in client affective‐meaning states, emotional arousal and emotional productivity. Results supported the emotion transformation model. The client presented in a state of poorly differentiated but highly aroused distress provoked by identifiable interpersonal and intrapersonal triggers. Emotional and behavioural avoidance provoked by fear of pain was evident. Accessing core pain and responding to attendant needs with compassion and protective anger was shown to facilitate the higher order emotional processing states of grief, relief and agency. Implications are proposed, including that addressing core emotional vulnerability may be a critical intervention in the successful treatment of GAD.
Net clinical benefit of dual antiplatelet therapy in elderly patients with acute coronary syndrome: A systematic review and meta‐analysis
Authors: Fujisaki Tomohiro , Kuno Toshiki , Iwagami Masao , Miyamoto Yoshihisa , Takagi Hisato , Deharo Pierre , Cuisset Thomas , Briasoulis Alexandros , Panaich Sidakpal , Latib Azeem , Kohsaka Shun 
Published: September 2023

AbstractBackgroundContemporary dual antiplatelet therapy (DAPT) strategies, such as short‐term DAPT or de‐escalation of DAPT, have emerged as attractive strategies to treat patients with acute coronary syndrome (ACS). However, it remains uncertain whether they are suitable for elderly patients.MethodsPubMed, Embase, and Cochrane CENTRAL databases were searched in September 2022. Randomized controlled trials (RCTs) investigating DAPT strategies, including standard (12 months), short‐term, uniform de‐escalation, and guided‐selection strategies for elderly patients with ACS (age ≥ 65 years) were identified, and a network meta‐analysis was conducted. The primary endpoint was the net clinical benefit outcome, a composite of major adverse cardiovascular events (MACEs: cardiovascular death, myocardial infarction, or stroke) and clinically relevant bleeding (equivalent to bleeding of at least type 2 according to the Bleeding Academic Research Consortium). The secondary outcomes were MACE and major bleeding.ResultsSixteen RCTs with a combined total of 47,911 patients were included. The uniform de‐escalation strategy was associated with an improved net clinical benefit compared with DAPT using potent P2Y12 inhibitors. The short‐term DAPT strategy was associated with reduced risks of the primary outcome and major bleeding compared with DAPT using potent P2Y12 inhibitors, however, it was ranked as the least effective strategy for MACE compared with other DAPT strategies.ConclusionsUniform de‐escalation and short‐term DAPT strategies may be advantageous for elderly patients, but need to be tailored based on individual bleeding and ischemic risks. Further RCTs of contemporary DAPT strategies specifically designed for elderly patients are warranted to confirm the findings of the present study.
Recent Progress on Carbon‐Based Electrocatalysts for Oxygen Reduction Reaction: Insights on the Type of Synthesis Protocols, Performances and Outlook Mechanisms
Authors: Mbokazi Siyabonga Patrick , Matthews Thabo , Chabalala Makhaokane Paulina , Selepe Cyril Tlou , Mugadza Kudzai , Gwebu Sandile Surprise , Mekuto Lukhanyo , Maxakato Nobanathi Wendy 
Published: September 2023

AbstractDue to their low cost, accessibility of resources, and improved stability and durability, carbon‐based nanomaterials have attracted significant attention as cathode materials for oxygen reduction reactions. These materials also exhibit intrinsic physical and electrochemical features. However, their potential for use in fuel cells is constrained by low ORR activity and slow kinetics. Carbon nanomaterials can be functionalized and doped with heteroatoms to change their morphologies and generate a large number of oxygen reduction active sites to lessen the problems. Doping the carbon lattice with heteroatoms like N, S, and P and functionalizing the carbon structure with −OCH3, −F, −COO−, −O− are two of these modifications that can change specific properties of the carbon nanomaterials like expanding interlayer distance, producing a large number of active sites, and enhancing oxygen reduction activity. When compared to pristine carbon‐based nanomaterials, these doped and functionalized carbon nanomaterials, including their composites, exhibit accelerated rate performance, outstanding stability, and higher methanol tolerance. This article summarizes the most recent developments in heteroatom‐doped and functionalized carbon‐based nanomaterials, covering different synthesis approaches, characterization methods, electrochemical performance, and oxygen reduction reaction mechanisms. As cathode materials for fuel cell technologies, the significance of heteroatom co‐doping and transition metal heteroatom co‐doping is also underlined.
Palladium Complexes of N‐Methylcorroles
Authors: Pizzoli Francesco , Mita Alessandro , Caroleo Fabrizio , Nardis Sara , Calice Umberto , Caporale Marilena , Belviso Sandra , Superchi Stefano , Marconi Alessia , Calvaresi Matteo , Capolungo Chiara , Prodi Luca , Smith Kevin M. , Fronczek Frank R. , Paolesse Roberto 
Published: September 2023

AbstractAlkylation of one of the inner‐core nitrogen atoms is one possible approach to obtain dianionic corrole ligands, suitable for the coordination of divalent metal ions, such as PdII. Inner‐core N‐methylation can be obtained by treating the corrole with CH3I, but the reaction conditions should be optimized to limit the formation of the dimethylated derivative. Two regioisomers, the N‐21 and the N‐22 methyl derivatives are obtained from the reaction, with the first product achieved in a higher amount. Structural characterization of the reaction products evidenced the distortion induced by the introduction of the methyl groups; the N‐methylcorroles are chiral compounds, and the enantiomers were separated by chromatography, with their absolute configuration assigned by ECD computation. Palladium insertion was achieved in the case of monosubstituted corroles, but not with the dimethylated macrocycle; X‐ray characterization of the complexes showed the distortion of the macrocycles. The Pd complexes do not show luminescence emission, but are able to produce singlet oxygen upon irradiation. The PdII complexes were also inserted in human serum albumin (HSA) and dispersed in water; in this case, the protein protects the corroles from photobleaching, and a switch from the type II to the type I mechanism in reactive oxygen species (ROS) production is observed.
Trends in der Mehrphasensimulation
Authors: Heck Ulrich , Becker Martin 
Published: September 2023

AbstractDie Entwicklung neuer Hybridmodelle in der Mehrphasen‐Strömungssimulation ermöglicht eine ganzheitliche Betrachtung von verfahrenstechnischen Prozessen. Damit können bei der Zerstäubung die Einflüsse der Düse und der gewählten Betriebsparameter auf die entstehende Partikelgröße und die späteren Sprayeigenschaften vorhergesagt und zur gezielten Prozessoptimierung genutzt werden.
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines
Authors: Federico Stephanie , Persico Margherita , Trevisan Letizia , Biasinutto Chiara , Bolcato Giovanni , Salmaso Veronica , Da Ros Tatiana , Gianferrara Teresa , Prencipe Filippo , Kachler Sonja , Klotz Karl‐Norbert , Pacor Sabrina , Moro Stefano , Spalluto Giampiero 
Published: September 2023

AbstractThe A3 adenosine receptor is an interesting target whose role in cancer is controversial. In this work, a structural investigation at the 2‐position of the [1,2,4]triazolo[1,5‐c]pyrimidine nucleus was performed, finding new potent and selective A3 adenosine receptor antagonists such as the ethyl 2‐(4‐methoxyphenyl)‐5‐(methylamino)‐[1,2,4]triazolo[1,5‐c]pyrimidine‐8‐carboxylate (20, DZ123) that showed a Ki value of 0.47 nM and an exceptional selectivity profile over the other adenosine receptor subtypes. Computational studies were performed to rationalize the affinity and the selectivity profile of the tested compounds at the A3 adenosine receptor and the A1 and A2A adenosine receptors. Compound 20 was tested on both A3 adenosine receptor positive cell lines (CHO‐A3AR transfected, THP1 and HCT16) and on A3 negative cancer cell lines, showing no effect in the latter and a pro‐proliferative effect at a low concentration in the former. These interesting results pave the way to further investigation on both the mechanism involved and potential therapeutic applications.
An investigation of color difference for binocular rivalry and a preliminary rivalry metric, ΔE*bino
Authors: Asano Yuta , Wang Minqi 
Published: September 2023

AbstractHead‐mounted displays (HMDs) for virtual and augmented reality applications could have severe nonuniformities due to complex optical components and the choice of light source technologies. In addition, module variations between the two eyes can result in different colors being seen with the left and right eyes. Binocular rivalry is expected for large color differences between the two eyes, which can severely affect product usability. Thus, it is important to characterize and predict the binocular rivalry in HMDs caused by interocular color differences. As a step toward this end, we propose the first binocular color difference metric, ΔE*bino, to predict the just noticeable binocular rivalry for a pair of solid colors. A psychophysical experiment was conducted using Meta Quest 2, in which we presented different colors to the left and right eye. The collected data were analyzed to derive the metric using ROC curves. We show that the ΔE*bino metric showed significant improvements over conventional color difference formulae. Both the ΔE*bino formula and the anonymized experiment results are available for download.
Constrained deformations of positive scalar curvature metrics, II
Authors: Carlotto Alessandro , Li Chao 
Published: September 2023

AbstractWe prove that various spaces of constrained positive scalar curvature metrics on compact three‐manifolds with boundary, when not empty, are contractible. The constraints we mostly focus on are given in terms of local conditions on the mean curvature of the boundary, and our treatment includes both the mean‐convex and the minimal case. We then discuss the implications of these results on the topology of different subspaces of asymptotically flat initial data sets for the Einstein field equations in general relativity.
Stimuli‐Responsive, Dynamic Supramolecular Organic Frameworks
Authors: Pedrini Alessandro , Marchetti Danilo , Pinalli Roberta , Massera Chiara 
Published: September 2023

AbstractSupramolecular organic frameworks (SOFs) are a class of three‐dimensional, potentially porous materials obtained by the self‐assembly of organic building blocks held together by weak interactions such as hydrogen bonds, halogen bonds, π⋅⋅⋅π stacking and dispersion forces. SOFs are being extensively studied for their potential applications in gas storage and separation, catalysis, guest encapsulation and sensing. The supramolecular forces that guide their self‐assembly endow them with an attractive combination of crystallinity and flexibility, providing intelligent dynamic materials that can respond to external stimuli in a reversible way. The present review article will focus on SOFs showing dynamic behaviour when exposed to different stimuli, highlighting fundamental aspects such as the combination of tectons and supramolecular interactions involved in the framework formation, structure‐property relationship and their potential applications.
Detection of SPV2 and SPCSV and their possible influence on the yield in multiple virus infections
Authors: Mmboyi Midana A. , Mulabisana Mapula J. , Laurie Sunette M. , van der Merwe Renate M. P. Roux , Cochrane Nicolene M. 
Published: September 2023

AbstractThe prevalence of Sweet potato virus 2 (SPV2) and Sweet potato chlorotic stunt virus (SPCSV) in the Limpopo, Mpumalanga, and Gauteng provinces of South Africa was determined using serological and nucleic acid based methods. Cloning and sequencing part of the coat protein (CP) gene and the complete genome using next generation sequencing (NGS) were also conducted to characterize and determine the sequence variability in SPV2 isolates. Primers designed in the current study successfully detected and confirmed the prevalence of SPV2 in the three provinces surveyed. The pairwise comparison of the amino acid (aa) sequences encoding the CP gene region confirmed that isolates in this study are related to SPV2, sharing a 94% to 99% CP aa identity with those originally reported in South Africa. The East African (EA) strain of SPCSV was also detected in the three provinces surveyed. Phylogenetic analysis using part of the CP encoding nucleotide (nt) sequences showed that the South African isolates correspond to but are distinct from the other EA strains of SPCSV used as reference sequences. Assessment of varieties and breeding lines’ response to multiple infection of potyviruses identified variety NC1560, breeding lines 2002‐21‐1 and 2006‐5‐4 as promising for inclusion in future breeding programs as sources of parent material for virus tolerance.
Closing the Gap: Towards a Fully Continuous and Self‐Regulated Kolbe Electrosynthesis
Authors: Drögemüller Patrick , Stobbe Tobias , Schröder Uwe 
Published: September 2023

AbstractIn this article, we address the transition of the Kolbe electrolysis of valeric acid (VA) to n‐octane as an exemplary electrosynthesis process from a batch reaction to a continuous, self‐regulated process. Based on a systematic assessment of chemical boundary conditions and sustainability aspects, we propose a continuous electrosynthesis including a simple product separation and electrolyte recirculation, as well as an online‐pH‐controlled VA feeding. We demonstrate how essential performance parameters such as product selectivity (S) and coulombic efficiency (CE) are significantly improved by the transition from batch to a continuous process. Thus, the continuous and pH‐controlled electrolysis of a 1 M valeric acid, starting pH 6.0, allowed a constantly high selectivity of around 47 % and an average Coulomb efficiency about 52 % throughout the entire experimental duration. Under otherwise identical conditions, the conventional batch operation suffered from lower and strongly decreasing performance values (Sn‐octane, 60min=10.4 %, Sn‐octane, 240min=1.3 %; CEn‐octane, 60min=7.1 %, CEn‐octane, 240min=0.5 %). At the same time, electrolyte recirculation significantly reduces wastes and limits the use of electrolyte components.
Robust control for non‐minimum phase and cross‐regulation in single‐inductor dual‐output boost converter
Authors: Yang Lin , Zhang Xuan , Wu Jiarong , Luo Liping 
Published: September 2023

SummarySingle‐inductor dual‐output (SIDO) boost converters are used extensively in modern power systems because of their small circuit volume and high efficiency. However, SIDO boost converters exhibit non‐minimum phase property, and the coupling of the inductor current results in coupled dual outputs leading to cross‐regulation, which seriously affects the dynamic performance and stability of the system. To settle the non‐minimum phase issue and suppress the cross‐regulation of SIDO boost converters, proposed herein is a robust control method, which combines the exact feedback linearization (EFL) theory, adaptive technology, and sliding mode control (SMC) method. A nonlinear mathematical model is established, and a set of output functions for full linearization are constructed based on EFL theory. Furthermore, the output functions are linearized, and two single‐input single‐output linear subsystems are obtained. The SMC technologies are used to control the linear subsystems to improve the robustness of the system, and an adaptive mechanism is adopted to update the sliding mode switching gain to reduce chattering. Furthermore, the global asymptotic stability of the control system is proved based on the Lyapunov theory, and the robustness of the closed‐loop system is verified. Simulation and experimental results show that the proposed approach provides better dynamic regulation performance compared with the existing method.
Assessment of the diet of the critically endangered northern hairy‐nosed wombat (Lasiorhinus krefftii) using DNA metabarcoding
Authors: Casey Fiona , Old Julie M. , Stannard Hayley Jade 
Published: September 2023

AbstractInvasive buffel grass (Cenchrus ciliaris) is considered a threat to the critically endangered northern hairy‐nosed wombat (Lasiorhinus krefftii; NHW). Buffel grass outcompetes native grasses, reducing availability of native food items for NHW, and causes more intense fires due to the large volumes of dead matter it produces. Previous studies suggested buffel grass was increasing in the diet; however, the diet of the NHW has not been reassessed for over two decades and was limited to Epping Forest National Park, with the population at Richard Underwood Nature Refuge having never been assessed. The recently released 2022 Recovery Action Plan for the species outlined objectives to assist its conservation and recommended the impact of buffel grass on the species' diet be investigated. This study aimed to determine: (1) which plant species are being consumed by the NHW; (2) the differences in the diet between sites; (3) differences between seasons; and (4) the abundance of buffel grass in the diet. The diet was assessed using DNA metabarcoding of scat samples collected from both sites from winter 2020 to spring 2021. Site and season significantly affected the diet of the NHW. Buffel grass dominated the diet and has increased in the diet since past assessments. The findings of this study will support population and habitat management of the critically endangered NHW. Enhanced knowledge of dietary items consumed at both sites will also assist efforts to locate additional sites suitable for translocation.
Costimulatory capacity of CD137 mAbs on T cells depends on elaborate CRD structures but not on blocking ligand‒receptor binding
Authors: Jin Xin , Yi Ling , Wang Xiaojue , Yan Zhuohong , Wei Panjian , Yang Bin , Zhang Hongtao 
Published: September 2023

AbstractCD137 is mainly a costimulatory receptor of CD8+ T cells. Two representative CD137 antibodies, utomilumab, and urelumab, show different costimulatory capacities in clinical trials. Balancing the antitumor effect and systemic toxicity of T cells activated by CD137 signaling is a challenge that requires clinical consideration. In this study, a panel of specific anti‐human CD137 monoclonal antibodies (mAbs) were prepared and their affinities, isotypes, CD137‐CRD (cysteine‐rich domain) binding regions, cross‐reactivity to mouse and rhesus CD137, inhibition of ligand‒receptor binding and costimulatory activities were analyzed. The results showed that anti‐human CD137 mAbs had high cross‐reactivity with rhesus CD137. MAbs fell into three clusters according to their different binding regions of the CD137 extracellular domain. They bound to CRDI+CRDII, CRDIII or CRDIV+STP. CRDIII‐binding mAbs had the strongest blocking activity. Highly costimulatory CD137 mAbs showed stronger abilities to promote CD8+ T‐cell proliferation. However, the costimulatory capacity of mAbs on T cells was not closely related to their ability to block CD137L‐CD137 binding and may be controlled by more elaborate CRD conformational structures. This study provides additional information for the development of next‐generation CD137 mAbs to meet clinical needs.
3D‐printed amperometric sensor for the detection of ethanol in saliva
Authors: Wrobel von Zuben Theodora , Kalinke Cristiane , Campos Janegitz Bruno , Gonçalves Salles Airton , Alves Bonacin Juliano 
Published: September 2023

AbstractIn this work, we report a non‐enzymatic and metal‐free ethanol sensor based on 3D PLA‐graphene electrodes. We evaluated the optimal activation treatment for PLA‐graphene to achieve a sensor for monitoring ethanol levels in saliva samples, following the legal limits for drivers in various countries. The analytical performance of the sensor was determined through amperometric measurements, demonstrating a linear detection ranging supporting electrolyte (0.990–19.3 mmol L−1) and artificial saliva sample (0.990–17.4 mmol L−1), with respective limits of detection of 0.135 and 0.239 mmol L−1. The 3D‐printed sensor exhibited excellent repeatability and reproducibility. This method was effectively employed for ethanol detection, highlighting its potential as an alternative approach for assessing ethanol levels in drivers while considering diverse legal regulations across different countries.
In situ produced exopolysaccharides by Bacillus coagulansIBRC‐M 10807 and its effects on properties of whole wheat sourdough
Authors: Farajinejad Zahra , Mohtarami Forogh , Pirouzifard Mirkhalil , Amiri Saber , Hamishehkar Hamed 
Published: September 2023

AbstractThis study aimed to investigate in situ exopolysaccharides (EPSs) production by Bacillus coagulans IBRC‐M 10807 under different fermentation conditions to improve the technical‐functional properties of whole wheat flour sourdough and obtain high‐quality products. For this purpose, the effectiveness of four efficient factors including B. coagulans (8 Log CFU/g), FOS (0%, 2.5%, and 5% based on flour weight), fermentation temperature (30, 35, and 40°C), and fermentation time (12, 18, and 24 h) was investigated on the production of functional sourdough. Our work focused on optimizing probiotic sourdough by investigating probiotic viability, pH, total titratable acidity, antioxidant properties, and EPS measurement. The first optimal formulation for maximized production of the in situ EPSs by the numerical optimization included FOS 0%, B. coagulans IBRC‐M 10807 8 Log CFU/g, fermentation temperature of 30°C, and fermentation time of 12 h. In this case, EPSs was 59.28 mg/g and probiotic was 10.99 Log CFU/g. The second optimal formula by considering the highest viability of probiotic together with EPS production was determined as FOS 4.71%, B. coagulans IBRC‐M 10807, 8 Log CFU/g, fermentation temperature of 30°C, and fermentation time of 20 h. The predicted amount of the EPSs and probiotic viability via the second formulation were 54.4 mg/g and 11.18 Log CFU/g, respectively. Analyses of optimal sourdough using FTIR, SEM, and DSC revealed that FOS and probiotics significantly reduced the enthalpy of amylopectin retrogradation and delayed it compared to other samples. Therefore, improving the final product's technological capabilities and shelf life can be credited with potential benefits.