bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Advanced Platelet-Rich Fibrin Associated with Zucchelli Technique in the Treatment of Cairo Type 1 Gingival Recession: Randomized Clinical Trial
Authors: Bin Luiza Roberta , Miola Ângela Esmeralda Zaparolli , Nassar Patricia Oehlmeyer , Vanolli Rafael da Silva , Pritsch Renata Kaori , Nascimento Marina Gabrielle do , Foltz Katyeli Regina Boufleuher , Nassar Carlos Augusto 
Published: March 2023

Aims: To evaluate the effectiveness of the Coronally Advanced Flap Modified by Zucchelli with A-PRF in root coverage in patients with Cairo type I gingival recession.
Study Design: Randomized Clinical Trial.
Place and Duration of Study: Sample: Department of Periodontics, between January and April 2022.
Methodology: The Consolidated Standards of Reporting Trials 2010 protocol was followed for sample selection and distribution. It was a prospective clinical study, split-mouth parallel randomized, including 54 recessions within Group MCAF+SCTG: Zucchelli Technique + SCTG; and Group 2: Zucchelli Technique + A-PRF; 6 blood samples were collected; centrifugation (1300 rpm for 14 minutes, with G force of 210); and preparation of A-PRF membranes in the Stainless Steel Kit (Intra-Luck®). For the analysis of the results, the periodontal indices of height and width of the GR, probing depth, clinical insertion level, gingival level, keratinized tissue width, keratinized gingival tissue thickness, and sensitivity level, were used in the initial period, with 90 and 180 days of follow-up. GraphPad Prism 8.0 program® was used for statistical analysis. ANOVA and TUKEY tests were performed. Kruskall-WALLIS and DUNN tests were performed to analyze the pain parameter, with significance level of 5%.
Results: Parameters probing depth and bleeding index remained without statistically significant changes in both groups. There was improvement in parameters height and width of the recession, height of the inserted gum, thickness of the gum and level of sensitivity in both groups. There was no statistically significant difference between groups.
Conclusion: There was clinical improvement in all criteria evaluated for both groups. Thus, the Coronally Advanced Flap modified by Zucchelli associated with A-PRF is as effective as the Coronally Advanced Flap modified by Zucchelli associated with SCTG.
Feasibility of Cassava Semolina (Attiéké) as a Vehicle for Food Fortification: A Survey in Areas of Côte d'Ivoire with High Levels of Childhood Micronutrient Deficiencies
Authors: Djaléga Franck Adjé , Gbogouri Grodji Albarin , Bamba Mandoué Stéphanie 
Published: March 2023

Aims: This study constitutes the first approach to a food program. It was carried out in order to make up a useful database for a nutritional intervention by evaluating the level and practices of consumption of cassava semolina (Attiéké) among school children in rural communities.
Study Design: This study was conducted from May 14 to 21, 2021 in elementary school in six villages in an area of Côte d'Ivoire that previously had a high incidence of childhood anemia.
Methods: A cross-sectional survey collected data from first- to sixth-grade school children and aged from five to fifteen years (n = 460). Children provided data on their cassava semolina consumption in response to individual structured interviews conducted in their elementary schools and in the presence of one of their parents.
Results: The results suggest that cassava semolina is an accessible, familiar and acceptable vehicle for food fortification to overcome nutritional deficits in children in this area. Cassava semolina is available throughout the year in this area. Children consumed an average of 95.5 g/day of cassava semolina and over three quarters of them (88.5%) had consumed this food on at least one day during the week prior to the survey. Cassava semolina was most often eaten for the midday meal (77.2%) in combination with fish (86.3%) and/or vegetables (79.1%). Finally, although cassava can be grown in this area, most children’s families (75.9%) purchased processed cassava semolina.
Conclusion: The fortification of semolina would have high penetration in the population. However, the survey also identified a major challenge to using cassava semolina as a vehicle for micronutrient fortification. This is the shelf life of fresh cassava semolina, which is only 3 to 4 days in the absence of refrigeration.
Isolation of Actinomycetes from Arachis hypogaea L. and Gossypium herbaceum L. for Screening Antibacterial and Antifungal Activities
Authors: Mehta J. S. , Odedra Kunal N. , Jadeja B. A. 
Published: March 2023

The principal objective of the present study was to check the antimicrobial activity of Actinomycetes isolated from soil samples collected from the fields of Arachis hypogea L. and Gossipium herbaceum L. against different plant pathogenic strains. Various soil samples were isolated from fields located near the Junagadh district, Gujarat, India. Isolation was followed by a serial dilution process which was later plated on Actinomycete Isolation Agar (AIA) media. Potential colonies were subjected to screening, purification, and storage in glycerol stock. Morphological and Biochemical characterization of the isolates was performed. Isolated candidates were subjected to extraction for the production of the antimicrobial compound. The antimicrobial activity of the purified extract of isolates was tested. Total 30 actinomycete isolates were evaluated for antagonistic activity against pathogenic microorganisms.
Isolates C-25, C-15, and G-1 showed the best results in the decreasing order of their potency against fungal pathogens, and C-5, C-25, C-14, and C-13 showed the best results in decreasing order of potency against bacterial pathogens. 3 isolates inhibited all 4 test fungi. 10 isolates inhibited 3 test fungi. 11 isolates inhibited 2 test fungi. 6 isolates did not inhibit any test fungi. 4 isolates show potent inhibition. 15 inhibited Macrophomina. C-10 showed a 1 cm inhibition zone & G-1 showed a 0.8 cm zone of inhibition. 12 isolates gave 0.2-0.6 cm zone and 15 isolates gave negative results against Macrophomina. C-10 showed a very potent zone of inhibition of 0.7 cm. 9 isolates showed a 0.1-0.5 cm zone of inhibition. 20 isolates did not show inhibition against Fusarium. 1 isolate C-11(a) gave the 1cm potent zone of inhibition. 15 isolates gave the 0.7-0.2cm inhibition of the growth. 14 isolates gave negative results against Alternaria fungus. From these results, it was concluded that isolates had antibacterial and antifungal activities and could be used in the development of new antibiotics for pharmaceutical or agricultural purposes.
Predicting the Neurodevelopmental Outcome in Extremely Preterm Newborns Using a Multimodal Prognostic Model Including Brain Function Information
Authors: Routier Laura , Querne Laurent , Ghostine-Ramadan Ghida , Boulesteix Julie , Graïc Solène , Mony Sandrine , Wallois Fabrice , Bourel-Ponchel Emilie 
Published: March 2023

ImportanceEarly assessment of the prognosis of preterm newborns is crucial for accurately informing parents and making treatment decisions. The currently available prognostic models rarely incorporate functional brain information from conventional electroencephalography (cEEG).ObjectiveTo examine the performance of a multimodal model combining (1) brain function information with (2) brain structure information (cranial ultrasonography), and (3) perinatal and (4) postnatal risk factors for the prediction of death or neurodevelopmental impairment (NDI) in extremely preterm infants.Design, Setting, and ParticipantsPreterm newborns (23-28 weeks’ gestational age) admitted to the neonatal intensive care unit at Amiens-Picardie University Hospital were retrospectively included (January 1, 2013, to January 1, 2018). Risk factors from the 4 categories were collected during the first 2 weeks post delivery. Neurodevelopmental impairment was assessed at age 2 years with the Denver Developmental Screening Test II. No or moderate NDI was considered a favorable outcome. Death or severe NDI was considered an adverse outcome. Data analysis was performed from August 26, 2021, to March 31, 2022.Main Outcomes and MeasuresAfter the selection of variables significantly associated with outcome, 4 unimodal prognostic models (considering each category of variable independently) and 1 multimodal model (considering all variables simultaneously) were developed. After a multivariate analysis for models built with several variables, decision-tree algorithms were run on each model. The areas under the curve for decision-tree classifications of adverse vs favorable outcomes were determined for each model, compared using bootstrap tests, and corrected for type I errors.ResultsA total of 109 newborns (58 [53.2% male]) born at a mean (SD) gestational age of 26.3 (1.1) weeks were included. Among them, 52 (47.7%) had a favorable outcome at age 2 years. The multimodal model area under the curve (91.7%; 95% CI, 86.4%-97.0%) was significantly higher than those of the unimodal models (P &amp;lt; .003): perinatal model (80.6%; 95% CI, 72.5%-88.7%), postnatal model (81.0%; 95% CI, 72.6%-89.4%), brain structure model (cranial ultrasonography) (76.6%; 95% CI, 67.8%-85.3%), and brain function model (cEEG) (78.8%; 95% CI, 69.9%-87.7%).Conclusions and RelevanceIn this prognostic study of preterm newborns, the inclusion of brain information in a multimodal model was associated with significant improvement in the outcome prediction, which may have resulted from the complementarity of the risk factors and reflected the complexity of the mechanisms that interfered with brain maturation and led to death or NDI.
Incidence of Newborn Drug Testing and Variations by Birthing Parent Race and Ethnicity Before and After Recreational Cannabis Legalization
Authors: Schoneich Sebastian , Plegue Melissa , Waidley Victoria , McCabe Katharine , Wu Justine , Chandanabhumma P. Paul , Shetty Carol , Frank Christopher J. , Oshman Lauren 
Published: March 2023

ImportanceThirty-seven US states and the District of Columbia mandate reporting newborns with suspected prenatal substance exposure to the state, and punitive policies that link prenatal substance exposure to newborn drug testing (NDT) may lead to disproportionate reporting of Black parents to Child Protective Services. The impact of recreational cannabis legalization on racial disproportionality in NDT is unknown.ObjectivesTo examine variations in the incidence and results of NDT by birthing parent race and ethnicity, variables associated with variation, and changes after statewide legalization of recreational cannabis.Design, Setting, and ParticipantsThis retrospective cohort study was conducted from 2014 to 2020 with 26 366 live births to 21 648 birthing people who received prenatal care at an academic medical center in the Midwestern United States. Data were analyzed from June 2021 to August 2022.ExposuresVariables included birthing parent age, race, ethnicity, marital status, zip code, insurance type, prenatal and newborn diagnoses codes, and prenatal urine drug test orders and results.Main Outcome and MeasuresThe primary outcome was an NDT order. Secondary outcomes were substances detected.ResultsAmong 26 366 newborns of 21 648 birthing people (mean [SD] age at delivery, 30.5 [5.2] years), most birthing parents were White (15 338 [71.6%]), were non-Hispanic (20 125 [93.1%]), and had private insurance coverage (16 159 [74.8%]). The incidence of NDT ordering was 4.7% overall (1237 newborns). Clinicians ordered more NDTs for Black compared with White newborns (207 of 2870 [7.3%] vs 335 of 17 564 [1.9%]; P &amp;lt; .001) when the birthing parent had no prenatal urine drug test, a presumably low-risk group. Overall, 471 of 1090 NDTs (43.3%) were positive for only tetrahydrocannabinol (THC). NDTs were more likely to be positive for opioids in White compared with Black newborns (153 of 693 [22.2%] vs 29 of 308 [9.4%]; P &amp;lt; .001) and more likely to be positive for THC in Black compared with White newborns (207 of 308 [67.2%] vs 359 of 693 [51.8%]; P &amp;lt; .001). Differences remained consistent after state recreational cannabis legalization in 2018. Newborn drug tests were more likely to be positive for THC after legalization vs before legalization (248 of 360 [68.9%] vs 366 of 728 [50.3%]; P &amp;lt; .001) with no significant interaction with race and ethnicity groups.Conclusions and RelevanceIn this study, clinicians ordered NDTs more frequently for Black newborns when no drug testing was done during pregnancy. These findings call for further exploration of how structural and institutional racism contribute to disproportionate testing and subsequent Child Protective Services investigation, surveillance, and criminalization of Black parents.
Aggregation‐induced emission polymer systems with circularly polarized luminescence
Authors: Yan Hewei , He Youling , Wang Dong , Han Ting , Tang Ben Zhong 
Published: March 2023

AbstractFunctional materials with circularly polarized luminescence (CPL) have attracted tremendous attention due to their promising applications in three‐dimensional displays, chiral recognition and catalysis, photoelectronic devices, contrast imaging, information encryption, and other fields. Among various CPL‐active materials, polymeric systems with aggregation‐induced emission (AIE) have emerged as excellent candidates because of their efficient aggregate‐state fluorescence, large solid‐state dissymmetry factor, excellent processibility, diversified self‐assembly behaviors, and readily switchable CPL properties. This review summarizes and discusses the recent progress as well as future perspective of diverse AIE polymer systems with CPL, including CPL‐active covalent AIE polymers, CPL‐active supramolecular AIE polymers, and AIEgen/polymer composites with CPL. According to the location or introduction method of AIEgen in polymer structures, this review further divides CPL‐active covalent AIE polymers into three categories, including polymers with AIEgen in main chains, polymers with AIEgen in side chains, and CPL‐active polymers with clusterization‐triggered emission. CPL‐active supramolecular AIE polymers are discussed based on the driving force for the formation of supramolecular polymers, including host–guest interactions, metal coordination, and other non‐covalent interactions. Moreover, examples on the construction of CPL‐active AIEgen/polymer composites by physically mixing AIEgens with chiral (supra)polymers are also presented. This review is anticipated to provide readers with an overall view on the design strategies of CPL‐active AIE polymers, and facilitate further research on the development of CPL materials and AIE polymers with advanced applications.
Metal‐organic framework stabilizes Cu7S4‐wrapped Cu2O heterostructure for photothermal‐promoted methanol/water reforming into hydrogen
Authors: Pi Yunhong , Zengcai Ziyu , Lin Wenting , Zhang Baofang , Wang Tiejun 
Published: March 2023

AbstractTo realize highly efficient in situ release of hydrogen energy from methanol reforming at lower operation temperature, the introduction of solar energy can effectively activate the methanol and significantly reduce activation energy of reaction. Herein, the hierarchical integration of photoactive Cu2O/Cu7S4 core‐shell nanospheres stabilized by MIL‐101(Cr) support for H2 evolution from photothermal‐driven aqueous phase reforming of methanol afforded nearly sixfold enhanced performance compared with thermocatalytic process. Impressively, the photothermal effect conferred the Cu2O/Cu7S4@MIL‐101(Cr) with unprecedented activity at low temperature subside to 100°C and accelerated the activation of water and methanol with distinctly decreased activation energy from 103.9 to 66.6 kJ·mol−1. Meanwhile, the enhanced catalyst stability and facilitated charge separation between Cu2O/Cu7S4 and MIL‐101(Cr) also contribute to the extraordinary photothermal‐enhanced H2 evolution with an overall turnover number of up to 14,266 in 60 h (apparent quantum efficiency of 25.08% at 365 nm), almost 10,000 times higher than that of Cu2O/Cu7S4.
Impact of age at diagnosis, sex, and immunopathological manifestations in 886 patients with pediatric chronic immune thrombocytopenia
Authors: Pincez Thomas , Fernandes Helder , Pasquet Marlène , Abou Chahla Wadih , Granel Jérome , Héritier Sébastien , Fahd Mony , Ducassou Stéphane , Thomas Caroline , Garnier Nathalie , Barlogis Vincent , Jeziorski Eric , Bayart Sophie , Chastagner Pascal , Cheikh Nathalie , Guitton Corinne , Paillard Catherine , Lejeune Julien , Millot Frédéric , Li‐Thiao Te Valérie , Mallebranche Coralie , Pellier Isabelle , Neven Bénédicte , Armari‐Alla Corinne , Carausu Liana , Piguet Christophe , Benadiba Joy , Pluchart Claire , Stephan Jean‐Louis , Deparis Marianna , Briandet Claire , Doré Eric , Marie‐Cardine Aude , Leblanc Thierry , Leverger Guy , Aladjidi Nathalie 
Published: March 2023

AbstractPediatric chronic immune thrombocytopenia (cITP) is a heterogeneous condition in terms of bleeding severity, second‐line treatment use, association with clinical and/or biological immunopathological manifestations (IMs), and progression to systemic lupus erythematosus (SLE). No risk factors for these outcomes are known. Specifically, whether age at ITP diagnosis, sex, or IMs impact cITP outcomes is unknown. We report the outcomes of patients with pediatric cITP from the French nationwide prospective cohort OBS'CEREVANCE. We used multivariate analyses to investigate the effect of age at ITP diagnosis, sex, and IMs on cITP outcomes. We included 886 patients with a median (min‐max) follow‐up duration of 5.3 (1.0–29.3) years. We identified an age cutoff that dichotomized the risk of the outcomes and defined two risk groups: patients with ITP diagnosed <10 years (children) and ≥ 10 years (adolescents). Adolescents had a two to four‐fold higher risk of grade ≥3 bleeding, second‐line treatment use, clinical and biological IMs, and SLE diagnosis. Moreover, female sex and biological IMs were independently associated with higher risks of biological IMs and SLE diagnosis, second‐line treatment use, and SLE diagnosis, respectively. The combination of these three risk factors defined outcome‐specific risk groups. Finally, we showed that patients clustered in mild and severe phenotypes, more frequent in children and adolescents, respectively. In conclusion, we identified that age at ITP diagnosis, sex, and biological IMs impacted the long‐term outcomes of pediatric cITP. We defined risk groups for each outcome, which will help clinical management and further studies.
MT‐ATP6 mitochondrial disease identified by newborn screening reveals a distinct biochemical phenotype
Authors: Tise Christina G. , Verscaj Courtney P. , Mendelsohn Bryce A. , Woods Jeremy , Lee Chung U. , Enns Gregory M. , Stander Zinandré , Hall Patricia L. , Cowan Tina M. , Cusmano‐Ozog Kristina P. 
Published: March 2023

AbstractAlthough decreased citrulline is used as a newborn screening (NBS) marker to identify proximal urea cycle disorders (UCDs), it is also a feature of some mitochondrial diseases, including MT‐ATP6 mitochondrial disease. Here we describe biochemical and clinical features of 11 children born to eight mothers from seven separate families who were identified with low citrulline by NBS (range 3–5 μM; screening cutoff >5) and ultimately diagnosed with MT‐ATP6 mitochondrial disease. Follow‐up testing revealed a pattern of hypocitrullinemia together with elevated propionyl‐(C3) and 3‐hydroxyisovaleryl‐(C5‐OH) acylcarnitines, and a homoplasmic pathogenic variant in MT‐ATP6 in all cases. Single and multivariate analysis of NBS data from the 11 cases using Collaborative Laboratory Integrated Reports (CLIR; https://clir.mayo.edu) demonstrated citrulline <1st percentile, C3 > 50th percentile, and C5‐OH >90th percentile when compared with reference data, as well as unequivocal separation from proximal UCD cases and false‐positive low citrulline cases using dual scatter plots. Five of the eight mothers were symptomatic at the time of their child(ren)'s diagnosis, and all mothers and maternal grandmothers evaluated molecularly and biochemically had a homoplasmic pathogenic variant in MT‐ATP6, low citrulline, elevated C3, and/or elevated C5‐OH. All molecularly confirmed individuals (n = 17) with either no symptoms (n = 12), migraines (n = 1), or a neurogenic muscle weakness, ataxia, and retinitis pigmentosa (NARP) phenotype (n = 3) were found to have an A or U mitochondrial haplogroup, while one child with infantile‐lethal Leigh syndrome had a B haplogroup.
Progress in the Electrochemical Synthesis of Organoboron Compounds
Authors: Moniruzzaman Mohammad , Afrin Sadia , Ali Md. Korban 
Published: March 2023

AbstractOrganoboron is a class of compounds widely used in organic synthesis, pharmaceuticals, material science, sensors, and so on. Therefore, the development of efficient and selective electrochemical methods to synthesize organoboron has attracted much interest as an emerging sustainable technique of organic synthesis. Here, we summarized research on electrochemical borylations, including the electrochemically driven borylation of arenes, alkanes, aryl, or alkyl halides, activated carboxylic acids etc., based on direct electrolysis and metal‐free organocatalysis. We focus on the reaction mechanisms involved in single‐electron transfer and other radical processes. We believe that this review will inspire electrochemists to discover more efficient transformations to expand this field of borylation.
Photo‐Activated Circularly Polarized Luminescence Film Based on Aggregation‐Induced Emission Copper(I) Cluster‐Assembled Materials
Authors: Jin Yan , Peng Qiu‐Chen , Xie Jing‐Wen , Li Kai , Zang Shuang‐Quan 
Published: March 2023

AbstractIn this study, a pair of chiral copper(I) cluster‐assembled materials (R/S‐2) was prepared, exhibiting unique photo‐response characteristics with a concentration‐wavelength correlation property in DMSO solution. By the combination of R/S‐2 with a polymethyl methacrylate (PMMA) matrix, the first photo‐activated circularly polarized luminescence (CPL) film was developed, the CPL signal (glum=9×10−3) of which could be induced by UV light irradiation. Moreover, the film exhibited a reversible photo‐response and extremely good fatigue resistance. Mechanism study revealed that the photo‐response properties of the R/S‐2 solution and film are attributed to the aggregation‐induced emission (AIE) characteristics of R/S‐2 and a photo‐induced deoxygenation process. This study enriches the types of luminescent cluster‐assembled molecules and provides a new strategy for the construction of metal cluster‐based stimuli‐responsive composite materials.
Effect of electrospun stereocomplex PLA fibers and modified cellulose nanocrystals on crystallization of poly(L‐lactic acid)
Authors: Wan Zhengwei , Li Meili , Zhuang Yaozhong , Tong Zaizai 
Published: March 2023

AbstractPoly(L‐lactic acid) (PLLA) is a biodegradable polymer that has attracted increasing attention due to its fantastic properties. Nevertheless, the disadvantages of PLLA, such as low crystallization rate and brittleness, limit its wide commercial applications. In the present work, electrospun stereocomplex PLA fibers (Sc‐fibers) and PLLA grafted cellulose nanocrystals (g‐CNCs) are prepared as nano‐fillers and then blended with PLLA matrix to prepare different nanocomposites. Both of nano‐fillers would accelerate the crystallization rate of PLLA, and as expected, g‐CNCs have much stronger nucleation ability towards PLLA than Sc‐fibers. Nevertheless, the crystallization of PLLA will decrease to some extent in the presence of both nano‐fillers of g‐CNCs and Sc‐fibers due to the preferential formation of stereocomplex crystals on the surfaces of CNCs. Moreover, the presence of nano‐fillers would enhance the mechanical properties of PLLA, such as the elongation at break can increase by four times after incorporating both g‐CNCs and Sc‐fibers. This work provides a new consideration for designing different nano‐fillers, especially for polymer matrices with low crystallization ability and brittleness.