bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Ethyl Acetate Fraction of Terminalia ivorensis on Ethanol Induced Infertility in Male Rats
Authors: Celestine Ugwu Obiora , Doris Umeakuana Chidinma , Gloria Ogbonna Chidera , Presca Ude Ogochukwu , Chekwube Adonu Cyril , Keneolisa Asogwa Felix , Casmir Uzoefuna Chima , Onyebuchi Idokoja Levi , Kingsley Nwokedi Chukwuebuka , Raymond Offia Ogbonna , Assumpta Anosike Chioma 
Published: January 2025

Background: This research investigates the Effect of Ethyl Acetate Fraction of Terminalia ivorensis on Ethanol Induced Infertility in Male Rats. Infertility is the inability to conceive after one year of unprotected intercourse for couples under 35, or after six months for those over 35. It affects both men and women, with various factors contributing to the condition. Terminalia ivorensis has been claimed from traditional healers for the treatment of infertility hence the study.
Method: Quantitative phytochemical analysis, toxicity test and other biochemical analysis was carried out using standard method.
Results: Seven hundred grammes (700 g) of dried crude sample of Ethyl acetate Fraction of Terminalia ivorensis leaves powder gave a percentage yield of 6.28%. The study revealed that flavonoids, tannins, and phenols were present in high concentration, alkaloids, terpenoids and glycosides were present in moderate concentration, whereas saponins, steroids and hydrogen cyanide were present in low concentration. The toxicity result showed that the extract was not toxic even at the highest dosage (5000 mg/kg body weight) administered, indicating that the extract is safe for consumption. The results shown in the Table 3 indicates that groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight of extract significantly (P < 0.05) increased in testosterone level when compared to positive control; whereas groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight of extract showed significantly (P < 0.05) higher in LH and FSH when compared with positive control. The results in the Table 3 showed that groups treated with 200mg/kg,400mg/kg and 600kg/kg body weight of extract significantly (P < 0.05) decreases in sluggish, and dead sperm level when compared with positive control whereas groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight significantly (P < 0.05) increased active, sperm count and normal sperm when compared with positive control.
Conclusion: The plant extract has ant infertility properties and can be recommend as an alternative therapy for infertility in male.
Bio-efficacy Studies of Unique in Relation to Growth, Yield and Shelf Life of Nanasaheb Purple Seedless Grape Variety Grown under Multilocation
Authors: Somkuwar R. G. , Landage Sadashiv , Jadhav A. S. , Karande P. S. , Kakade P. B. 
Published: January 2025

Grape production, particularly seedless varieties like Nanasaheb Purple Seedless is highly valued for both domestic and export markets. However, environmental stresses such as drought and salinity often affect the quality and yield of grapes. This study explored the effectiveness of bio-stimulant (Unique) enhancing grape yield, quality and shelf life across two locations: ICAR-NRC for Grapes, Pune and Walwa, Sangli District of Maharashtra. While, bio-stimulants have shown potential in promoting vine growth and stress resilience, there is limited research on the optimal dosage and application timing for specific varieties like Nanasaheb Purple Seedless. The primary objective of this study was to identify the most effective dose and application schedule of Unique to maximize yield, berry quality and shelf life. A randomized block design (RBD) was employed with three treatment levels (20, 25 and 30 ml/L) of Unique applied through foliar spray at five key growth stages. Growth, yield, and quality parameters were measured and compared with control. Results revealed that Unique application of 30 ml/L at five critical growth stages significantly enhanced bunch weight, berry size and yield. Additionally, biochemical markers such as phenol, protein and reducing sugar levels also increased. Leaf area and chlorophyll content in leaf also improved facilitating better nutrient absorption and photosynthesis. Shelf life was extended with reduced weight loss during storage. The foliar application of 30 ml of Unique at specific growth stages is recommended to optimize the quality, yield and shelf life of Nanasaheb Purple Seedless grapes.
Micropattern‐Based Stem Cell Gym: Mechanical Memory Enhanced Stemness Maintenance of Human Dental Pulp Stem Cells and Nerve Regeneration
Authors: Li Chiyu , Meng Fanqi , Yang Zhijie , Peng Jiang , Guo Yuwei , Na Jing , Shi Qiusheng , Liu Yu , Wang Yu , Zheng Lisha , Fan Yubo 
Published: August 2023

AbstractDental pulp stem cells (DPSCs) which are derived from the neural crest are promising tools in stem cell therapy in the clinic. However, they tend to lose their multi‐lineage potency spontaneously during long‐term expansion in vitro. A micropattern‐based system is developed to train DPSCs with 1024 µm2 and aspect ratios of 1:2 and 1:4, which enhances their stemness and differentiation potential. This mechanical memory induced by micropattern would also rescue the pluripotency of long‐term expansion DPSCs. Micropatterns remodel the cytoskeleton and nuclear morphology, soften the cells, and induce the mitochondria into an immature state. Micropattern also activates extracellular related kinase, signal transducer, and activator of transcription 3, and inhibits Yes‐associated protein nuclear localization to enhance the stemness of DPSCs. In vivo implantation proves that DPSCs mechanically trained by micropattern could promote nerve regeneration in rats with peripheral nerve injury. A micropattern‐based approach is provided as a stem cell gym that absents exogenous growth factors to enhance the stemness and regenerative properties of DPSCs. It may shed light on future stem cell therapy.
Ultra‐Flyweight Cryogels of MXene/Graphene Oxide for Electromagnetic Interference Shielding
Authors: Ghaffarkhah Ahmadreza , Hashemi Seyyed Alireza , Rostami Sara , Amini Majed , Ahmadijokani Farhad , Pournaghshband Isfahani Ali , Mhatre Sameer E. , Rojas Orlando J. , Kamkar Milad , Wuttke Stefan , Soroush Masoud , Arjmand Mohammad 
Published: August 2023

AbstractMXene and graphene cryogels have demonstrated excellent electromagnetic interference (EMI) shielding effectiveness due to their exceptional electrical conductivity, low density, and ability to dissipate electromagnetic waves through numerous internal interfaces. However, their synthesis demands costly reduction techniques and/or pre‐processing methods such as freeze‐casting to achieve high EMI shielding and mechanical performance. Furthermore, limited research has been conducted on optimizing the cryogel microstructures and porosity to enhance EMI shielding effectiveness while reducing materials consumption. Herein, a novel approach to produce ultra‐lightweight cryogels composed of Ti3C2Tx/graphene oxide (GO) displaying multiscale porosity is presented to enable high‐performance EMI shielding. This method uses controllable templating through the interfacial assembly of filamentous‐structured liquids that are readily converted into EMI cryogels. The obtained ultra‐flyweight cryogels (3–7 mg cm−3) exhibit outstanding specific EMI shielding effectiveness (33 000–50 000 dB cm2 g−1) while eliminating the need for chemical or thermal reduction. Furthermore, exceptional shielding is achieved when the Ti3C2Tx/GO cryogels are used as the backbone of conductive epoxy nanocomposites, yielding EMI shielding effectiveness of 31.7–51.4 dB at a low filler loading (0.3–0.7 wt%). Overall, a one‐of‐a‐kind EMI shielding system is introduced that is readily processed while affording scalability and performance.
Resolving the Ultrafast Charge Carrier Dynamics of 2D and 3D Domains within a Mixed 2D/3D Lead‐Tin Perovskite
Authors: Hutchinson Jake D. , Ruggeri Edoardo , Woolley Jack M. , Delport Géraud , Stranks Samuel D. , Milot Rebecca L. 
Published: August 2023

AbstractMixed 2D/3D perovskite materials are of particular interest to the photovoltaics and light‐ emitting diode (LED) communities due to their impressive opto‐electronic properties alongside improved moisture stability compared to conventional 3D perovskite absorbers. Here, a mixed lead‐tin perovskite containing distinct, self‐assembled domains of either 3D structures or highly phase‐pure Ruddlesden–Popper 2D structures is studied. The complex energy landscape of the material is revealed with ultrafast optical transient absorption measurements. It is shown that charge transfer between these microscale domains only occurs on nanosecond timescales, consistent with the large size of the domains. Using optical pump‐terahertz probe spectroscopy, the effective charge‐carrier mobility is shown to be an intermediary between analogous pure 2D and 3D perovskites. Furthermore, detailed analysis of the free carrier recombination dynamics is presented. By combining results from a range of excitation wavelengths within a full dynamic model of the photoexcited carrier population, it is shown that the 2D domains in the film exhibit remarkably similar carrier dynamics to the 3D domains, suggesting that long‐range charge‐transport should not be impeded by the heterogeneous structure of the material.
Shining Light on Carbon Aerogel Photocatalysts: Unlocking the Potentials in the Quest for Revolutionizing Solar‐to‐Chemical Conversion and Environmental Remediation
Authors: Wong Khai Jie , Foo Joel Jie , Siang Tan Ji , Ong Wee‐Jun 
Published: August 2023

AbstractThe past few years have witnessed a surge of interest in the development of carbon aerogel‐based photocatalysts, stemming from their fascinating characteristics that encompass the inherent properties of 2D carbon‐based nanomaterials and unique 3D structural features. Benefitting from their auspicious physicochemical characteristics, including low density, abundant active sites, and remarkable electrical conductivity, carbon aerogels have emerged as promising candidates for photocatalysis in energy and environmental applications. Thus, this review presents a panorama of state‐of‐the‐art advancements underlying the synthesis and modifications of carbon aerogel‐based nanocomposites for enhanced performance in photocatalytic applications. The synthetic strategies followed by the unique roles of carbon aerogel are highlighted to decipher the auspicious roles of carbon aerogels in bolstering photocatalytic activity. Additionally, the fundamental mechanism behind carbon aerogel‐based photocatalysts as well as their modifications are thoroughly discussed. Thereafter, the works on the photocatalytic applications of carbon aerogel in solar‐driven hydrogen evolution, CO2 reduction, pollutant decontamination, and bacteria inactivation, in the past 5 years are summarized with insights into charge dynamics being unveiled. Lastly, this review will prospect the ongoing challenges and future outlook of carbon aerogel‐based heterostructures in photocatalysis, aiming to facilitate the development of carbon aerogel‐based photocatalysts at the forefront of this research.
Highly Deformable Rigid Glassy Conjugated Polymeric Thin Films
Authors: Wang Yunfei , Zhang Song , Freychet Guillaume , Li Zhaofan , Chen Kai‐Lin , Liu Chih‐Ting , Cao Zhiqiang , Chiu Yu‐Cheng , Xia Wenjie , Gu Xiaodan 
Published: August 2023

AbstractWearable devices benefit from the use of stretchable conjugated polymers (CPs). Traditionally, the design of stretchable CPs is based on the assumption that a low elastic modulus (E) is crucial for achieving high stretchability. However, this research, which analyzes the mechanical properties of 65 CP thin films, challenges this notion. It is discovered that softness alone does not determine stretchability; rather, it is the degree of entanglement that is critical. This means that rigid CPs can also exhibit high stretchability, contradicting conventional wisdom. To inverstigate further, the mechanical behavior, electrical properties, and deformation mechanism of two model CPs: a glassy poly(3‐butylthiophene‐2,5‐diyl) (P3BT) with an E of 2.2 GPa and a viscoelastic poly(3‐octylthiophene‐2,5‐diyl) (P3OT) with an E of 86 MPa, are studied. Ex situ transmission X‐ray scattering and polarized UV–vis spectroscopy revealed that only the initial strain (i.e., <20%) exhibits different chain alignment mechanisms between two polymers, while both rigid and soft P3ATs showed similarly behavior at larger strains. By challenging the conventional design metric of low E for high stretchability and highlighting the importance of entanglement, it is hoped to broaden the range of CPs available for use in wearable devices.
High‐Performance Multi‐Resonance Thermally Activated Delayed Fluorescence Emitters for Narrowband Organic Light‐Emitting Diodes
Authors: Jiang He , Jin Jibiao , Wong Wai‐Yeung 
Published: August 2023

AbstractMulti‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters have drawn considerable attention because of their remarkable optoelectronic properties of high emission efficiency and narrow emission profile, and represent an active subject of cutting‐edge research in the organic electroluminescence (EL). However, the slow reverse intersystem crossing (RISC) rate of MR‐TADF emitter caused by the large energy gap (ΔEST) and small spin‐orbit coupling (SOC) matrix elements between the singlet and triplet excited states limits their further development in organic EL devices. Currently, innovative molecular design strategies have been developed including heavy atom integration, π‐extended MR framework and metal perturbation, and so on to improve the RISC process of MR‐TADF emitters for high‐performance EL devices. Here, an overview is presented on the recent progress of MR‐TADF emitters with fast RISC rate ( > 10−5 s−1), with particular attention to the molecular design, optoelectronic properties, and device performance of organic light‐emitting diodes (OLEDs), which intends to systematize the knowledge in this subject for the thriving development of highly efficient MR‐TADF emitters. Finally, the challenges and future prospects of MR‐TADF materials are discussed comprehensively.
CoFePS Quaternary Alloy Sub‐Nanometric Sheets by Synchronously Phospho‐Sulfurizing CoFe‐Bimetallene for Boosting Oxygen Evolution Reaction
Authors: Zhao Long , Wen Ming , Guo Yibo , Wu Qingsheng , Zhu Quanjing , Fu Yongqing 
Published: August 2023

AbstractDue to the sluggish kinetics of oxygen evolution reaction (OER), electrocatalysts are urgently needed to simultaneously achieve increased activity, enhanced stability, and reduced cost. Herein, CoFePS quaternary alloy sub‐nanometric sheet is synthesized via synchronously phosphor‐sulfurizing CoFe‐bimetallene. Heteroatomization results in increasing conductivity, enhancing interactions with electrolyte, and improving chemical structural stability to exhibit a current density of 10 mA cm−2 at 211 mV and a large current of 1053 mA cm−2 at 570 mV. Density functional theory calculations reveal that the adjustment of Fermi levels of adjacent metal atoms reduces reaction energy barrier and accelerates electron transfer, resulting in a Tafel slope of 14 mV dec−1. In situ Raman monitors the formation of phosphor‐sulfate shell oxidized surface as active sites improved the OER stability of CoFePS, with a retention rate of 99.7% at 10 mA cm−2 for 78 h. This study provides a promising strategy for the synthesis of multicomponent alloy sub‐nanometric sheet as good electrocatalyst candidates for OER.
DNAzyme‐Mediated Cascade Nanoreactor for Cuproptosis‐Promoted Pancreatic Cancer Synergistic Therapy
Authors: Yu Qiao , Zhou Jie , Liu Yong , Li Xiao Qiong , Li Shan , Zhou Hong , Kang Bin , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: August 2023

AbstractCuproptosis, a kind of newly recognized cell death modality, shows enormous prospect in cancer treatment. The inducer of cuproptosis has more advantages in tumor therapy, especially that can trigger cuproptosis and chemodynamic therapy (CDT) simultaneously. However, cuproptosis is restricted to the deficiency of intracellular copper ions and the nonspecific delivery of copper‐based ionophores. Therefore, high level delivery, responsive release, and utilizing synergistic‐function of inducer become the key on cuproptosis‐based oncotherapy. In this work, a cascade nanosystem is constructed for enhanced cuproptosis and CDT. In the weak acidic environment of tumor cells, DNA, zinc ions, and Cu+ can release from the nanosystem. Since Cu+ having superior performance in mediating both Fenton‐like reaction and cuproptosis, the released Cu+ induces cuproptosis and CDT efficiently, accompanied by Cu2+ generation. Then Cu2+ can be converted into Cu+ partially by glutathione (GSH) to from a Cu+ supply loop and ensure the synergistic action. Meanwhile, the consumption of GSH also contributes to cuproptosis and CDT in return. Finally, DNA and Zn2+ form DNAzyme to shear catalase‐related RNA, resulting in the accumulation of hydrogen peroxide and further enhancing combination therapy. These results provide a promising nanotherapeutic platform and may inspire the design for potential cancer treatment based on cuproptosis.
Ultrarapid‐Acting Microneedles for Immediate Delivery of Biotherapeutics
Authors: You Jiahuan , Yang Changwei , Han Jinpeng , Wang Hao , Zhang Wentao , Zhang Ying , Lu Ziyi , Wang Shiqi , Cai Ruisi , Li Hongjun , Yu Jicheng , Gao Jianqing , Zhang Yuqi , Gu Zhen 
Published: August 2023

AbstractSubcutaneous (SC) injection is a common administration route for rapid and efficient delivery of biotherapeutics. However, syringe‐based injections usually require professional assistance and are associated with pain and potential risks of infections, thus leading to undesired patient compliance and poor life quality. Herein, this work presents an ultrarapid‐acting microneedle (URA‐MN) patch for immediate transdermal delivery of therapeutics in a minimally invasive manner. Effervescent agents are incorporated into the tip of URA‐MN for rapid generation of CO2 bubbles upon insertion into the skin, immediately powering the biotherapeutics release within a few minutes. The release kinetics of diverse agents including liraglutide (LRT), insulin, and heparin from the URA‐MN patches are evaluated in three different mouse models, and the rapid release of biotherapeutics and potent therapeutic effects are achieved with only 5 min administration. Noteworthily, attributed to the short application duration and negligible residuals of MN matrix remaining in the skin, the URA‐MN patch shows desirable biocompatibility after six‐week administration.
Stabilizing Metal Halide Perovskites for Solar Fuel Production: Challenges, Solutions, and Future Prospects
Authors: Peng Shaomin , Yang Zhuoying , Sun Ming , Yu Lin , Li Yanguang 
Published: August 2023

AbstractMetal halide perovskites (MHPs) are emerging photocatalyst materials that can enable sustainable solar‐to‐chemical energy conversion by virtue of their broad absorption spectra, effective separation/transport of photogenerated carriers, and solution processability. Although preliminary studies show the excellent photocatalytic activities of MHPs, their intrinsic structural instability due to the low formation energy and soft ionic nature is an open challenge for their practical applications. This review discusses the latest understanding of the stability issue and strategies to overcome this issue for MHP‐based photocatalysis. First, the origin of the instability issue at atomic levels and the design rules for robust structures are analyzed and elucidated. This is then followed by presenting several different material design strategies for stability enhancement, including reaction medium modification, material surface protection, structural dimensionality engineering, and chemical composition engineering. Emphases are placed on understanding the effects of these strategies on photocatalytic stability as well as the possible structure‐performance correlation. Finally, the possible future research directions for pursuing stable and efficient MHP photocatalysts in order to accelerate their technological maturity on a practical scale are outlined. With that, it is hoped to provide readers a valuable snapshot of this rapidly developing and exciting field.
Boosting Solid‐State Reconversion Reactivity to Mitigate Lithium Trapping for High Initial Coulombic Efficiency
Authors: Cao Shengkai , Zhu Zhiqiang , Zhang Wei , Xia Huarong , Zeng Yi , Yuan Song , Ge Xiang , Lv Zhisheng , Wei Jiaqi , Liu Lin , Du Yonghua , Xi Shibo , Loh Xian Jun , Chen Xiaodong 
Published: August 2023

AbstractAn initial Coulombic efficiency (ICE) higher than 90% is crucial for industrial lithium‐ion batteries, but numerous electrode materials are not standards compliant. Lithium trapping, due to i) incomplete solid‐state reaction of Li+ generation and ii) sluggish Li+ diffusion, undermines ICE in high‐capacity electrodes (e.g., conversion‐type electrodes). Current approaches mitigating lithium trapping emphasize ii) nanoscaling (<50 nm) to minimize Li+ diffusion distance, followed by severe solid electrolyte interphase formation and inferior volumetric energy density. Herein, this work accentuates i) instead, to demonstrate that the lithium trapping can be mitigated by boosting the solid‐state reaction reactivity. As a proof‐of‐concept, ternary LiFeO2 anodes, whose discharged products contain highly reactive vacancy‐rich Fe nanoparticles, can alleviate lithium trapping and enable a remarkable average ICE of ≈92.77%, much higher than binary Fe2O3 anodes (≈75.19%). Synchrotron‐based techniques and theoretical simulations reveal that the solid‐state reconversion reaction for Li+ generation between Fe and Li2O can be effectively promoted by the Fe‐vacancy‐rich local chemical environment. The superior ICE is further demonstrated by assembled pouch cells. This work proposes a novel paradigm of regulating intrinsic solid‐state chemistry to ameliorate electrochemical performance and facilitate industrial applications of various advanced electrode materials.
“Ice and Fire” Supramolecular Cell‐Conjugation Drug Delivery Platform for Deep Tumor Ablation and Boosted Antitumor Immunity
Authors: Xu Meng , Zha Haidong , Chen Jiamao , Lee Simon Ming‐Yuen , Wang Qi , Wang Ruibing , Zheng Ying 
Published: August 2023

AbstractCancer recurrence and metastasis are two major challenges in the current clinical therapy. In this work, a novel diketopyrrolopyrrole‐based photothermal reagent (DCN) with unique J‐aggregation‐induced redshift is synthesized to achieve efficient tumor thermal ablation under safe power (0.33 W cm−2). Meanwhile, S‐nitroso‐N‐acetylpenicillamine (SNAP) is co‐loaded with near‐infrared‐absorbing DCN in amphiphilic polymers to realize heat‐induced massive release of nitric oxide (NO), which can form oxidant peroxynitrite (ONOO−) to active matrix metalloproteinases (MMPs), thereby degrading the compact tumor extracellular matrix to improve the ablation depth and infiltration of immune cells. Through a facile supramolecular assembly method, the DCN/SNAP nanoparticles are anchored to liquid‐nitrogen‐frozen cancer cells, achieving enhanced antitumor immune responses and effective inhibition of distant tumors and pulmonary metastases after only one treatment. The safety and effectiveness of this supramolecular cell‐conjugation platform are verified by 2D/3D cellular experiments and bilateral tumor model, confirming the thermal‐ablation–gas‐permeation–antigen‐presentation therapeutic mode has promising anticancer prospects.