bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling Explainable Artificial Intelligence To Narrate Patent Scenarios in Devising Science Policy Decisions &amp; Technology Forecasts
Authors: Hasan Zeba , Alam M Afshar , Kaur Harleen , Khan Ihtiram Raza , Alankar Bhavya 
Published: June 2023

Abstract
Machine learning methods, offering unique characteristics for variable identification and it’s importance, are now gradually used for prediction, forecasting and devising important scenarios for integral decision-making. Sequential and dynamic growth in technology can fundamentally become a foremost indicator in measuring technology strength in innovative technology-based development. Prudent and systematic data generation is part of the same transition phase playing an equivalent role in creating evidence analysis and service/product development. Assisted solutions of machine learning provide data-driven prediction at core level areas of medical analysis, fraud detection & disease detection, etc. to predict solutions with explainable intelligence. Assisting solutions with more data-driven explainable solutions, during performance of advanced machine learning has created an advanced methodology of generating white box solutions out of the black box interpretation. Explainable artificial intelligence, which gives superior and solution-based AI is not only providing optimal solutions but also provides an impactful decision-making solution. The approach of explainable artificial intelligence being used here represents and mediate assessment for ML algorithms to predict accurate results. Innovation and development, whereby can be identifies via the various innovation indicators, where patents are one of the important solution providers on way for futuristic technology and innovation solution. Patent expansion potentials have been initially proposed by prediction and forecasting of patents, to be considered in identifying technology trends and improving policy decision-making. Now in this paper standardised use of patent values extracted from Organisation for Economic Cooperation and Development (OECD) database of patents for India have been taken to represent technological mandate.
Xylan derived carbon dots composite with cotton cellulose paper as fluorescence sensor for real time detection Cu2+
Authors: Zhang Yingying , Feng Xiuyuan , Chen Zhiyuan , Cui Xiaoci , Xiao Huining , Xiong Ranhua , Huang Chaobo 
Published: June 2023

Abstract
Cotton cellulose paper composited with fluorescence carbon dots (CDs) has shown potential for Cu2+ detection in environmental monitoring. In this study, a solid-state detection platform was developed using biomass-based fluorescent sensors (CPU-CDs) composed of xylan-derived CDs (U-CDs) and cotton cellulose paper. The fluorescence platform was nanoengineered to monitor Cu2+ changes via spectral and colorimetric dual-modal methods. CPU-CDs exhibits reusability, non-toxicity, excellent fluorescence characteristics and biocompatibility. Besides, CPU-CDs has a complex network structure and a large number of hydroxyl and amino groups, which can realize a high loading rate of U-CDs and provide more binding sites for the detection and response of Cu2+. CPU-CDs displays high effectiveness and sensitivity for Cu2+. Additionally, the detection limit of CPU-CDs for Cu2+ as low as 0.14 μM that was well below U.S. EPA safety levels (20 μM). Practical application indicated that CPU-CDs could achieve precision response of Cu2+ change in water environment with recovery range of 90%-119%. This strategy demonstrated a promising biomass solid-state fluorescence sensor for Cu2+ detection for water treatment research.
Flow cytometry-based peripheral blood analysis as an easily friendly tool for prognostic monitoring of acute ischemic stroke: a multicenter study
Authors: Lu Kang , Yue Juanqing , Ni Wanmao , Du Jing , Li Yanchun , Tong Xiangmin , Chen Guo-Bo , Wang Ying 
Published: June 2023

Abstract
Background and Objective Acute ischemic stroke (AIS) is a leading cause of mortality, severe neurological and long-term disability world-wide. Blood-based indicators may provide valuable information on identified prognostic factors. However, currently, there is still a lack of peripheral blood indicators for the prognosis of AIS. We aimed to identify the most promising prognostic indicators and establish prognostic models for AIS.
Methods 484 patients enrolled from four centers were analyzed immunophenotypic indicators of peripheral blood by flow cytometry. Least absolute shrinkage and selection operator (LASSO) regression was applied to minimize the potential collinearity and over-fitting of variables measured from the same patient and over-fitting of variables. Univariate and multivariable Cox survival analysis of differences between and within cohorts was performed by log-rank test. The areas under the receiving operating characteristic (ROC) curves were used to evaluate the selection accuracy of immunophenotypic indicators in identifying AIS subjects with survival risk. The prognostic model was constructed using a multivariate Cox model, consisting of 402 subjects as a training queue and 82 subjects as a testing queue.
Results In the prospective study, 7 immunophenotypic indicators of distinct significance were screened out of 72 peripheral blood immunophenotypic indicators by LASSO. In multivariate cox regression, CTL (%) [HR: 1.18, 95% CI: 1.03-1.33], monocytes/μl [HR: 1.13, 95% CI: 1.05-1.21], non-classical monocytes/μl [HR: 1.09, 95% CI: 1.02-1.16] and CD56high NK cells/μl [HR: 1.13, 95% CI: 1.05-1.21] were detected to decrease the survival probability of AIS, while Tregs/μl [HR:0.97, 95% CI: 0.95-0.99, p=0.004], BM/μl [HR:0.90, 95% CI: 0.85-0.95, p=0.023] and CD16+NK cells/μl [HR:0.93, 95% CI: 0.88-0.98, p=0.034] may have the protective effect. As for indicators’ discriminative ability, the AUC for CD56highNK cells/μl attained the highest of 0.912. In stratification analysis, the survival probability for AIS patients with a higher level of Tregs/μl, BM/μl, CD16+NK cells/μl, or lower levels of CD56highNK cells/μl, CTL (%), non-classical monocytes/μl, Monocytes/μl were more likely to survive after AIS. The multivariate Cox model showed an area under the curve (AUC) of 0.805, 0.781 and 0.819 and 0.961, 0.924 and 0.982 in the training and testing cohort, respectively.
Conclusion Our study identified 7 immunophenotypic indicators in peripheral blood may have great clinical significance in monitoring the prognosis of AIS and provide a convenient and valuable predictive model for AIS.
Design and Development of Ticare Applications in Medical Services Assessment for People in Eastern Economic Corridor (EEC) of Thailand
Authors: Xayavong Boy , Jirakajohnkool Supet , Pannucharoenwong Nattadon , Janchompu Wachirathorn , Niammuad Damrongrit , Pawa Kammal Kumar 
Published: June 2023

Abstract
Introduction
Eastern Economic Corridor (EEC) has found that there is a high risk of Non-communicable diseases (NCDs), such as cancer, blood pressure, diabetes and cerebrovascular disease, in eastern region. The rate of major NCDs increased from 4,987 per 100,000 people in 2017 to 6,121 in 2021.
Methods
The researchers have developed an application specifically for kidney disease patients. It serves as a resource for knowledge and facilitates greater public accessibility to healthcare, complying with SDGs in Good Health and well-being. The aims are 1) to develop the application in the EEC area with key functions of searching for nearest medical facility, booking online service, teleconferencing, and reporting in Data Visualization and 2) to evaluate the results of Mobile Health.
Results
We work with Geo-Informatics and Space Technology Development Agency (Public Organization) – GISTDA, secondary data from government centers are integrated with geographic information systems to display spatial data. The process is based on Flutter for a cross-platform, minimizing the disparity of public medical services access as it can be reached on any device and everywhere. The application, offering 3 login options (guest, member, and administration), was evaluated by 400 test subjects.
Discussion
The results show a very high level of satisfaction and 5% margin of error. Therefore, the application makes it simple to track symptoms using a medical call system, which can improve access to medical services and lighten doctors' workloads. Within the application, doctors can prescribe and offer helpful advice on how to develop sustainable health knowledge and awareness.
A novel finite element model for the flare joint contact status at the seal ring with multiscale factors during assembly
Authors: Deng Lichuan , Luo Bin , Zhang Kaifu , Cheng Hui , Lin Langkun , Liang Biao 
Published: June 2023

Abstract
The sealing performance of a hydraulic system is determined by the joint’s interfacial contact status, which is impacted by unavoidable assembly errors and joint manufacturing deviations on multiple scales. A novel geometric analysis model was heuristically developed for incorporating the macroscopic and mesoscopic topographies into the accurate estimation of the contact surfaces' initial relative assembly position. The microscopic contact model is subsequently constructed using the reverse reconstruction method based on the measured characteristics of rough surfaces. In conjunction with the relative contact position, a multiscale finite element contact model of the interface in the assembly was generated. The simulated indentation results are then compared to experimental data for selected typical circumferential angles, while the impact of topography at each scale is investigated. The findings show the variation in the seal formation tendencies and illustrate how effectively the model can predict the contact status at the seal ring. The influence of the macroscopic mating angle is mostly apparent in the distribution of plastic deformation along the circumferential direction. The mesoscopic flare angle is mostly reflected in the width and depth of the interfacial depression, and the radial circular runout impacts the seal ring formation process by altering the contact phase.
Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
Authors: Wang Qian , Liang Pei , Xu Ying , Yuan Binbin , Lan Chen , Yan Xiaodi , Li Li 
Published: June 2023

Abstract
Purpose
To analyze the risk factors influencing the development of cefoperazone (CPZ)-induced coagulopathy in critically ill patients and determine the threshold of serum trough concentration.
Methods
A retrospective case-control study was conducted in the intensive care unit (ICU) patients treated with CPZ and it was approved by the Ethical Committee of Drum Tower Hospital affiliated with the Medical School of Nanjing University (NO.2023-158-01). Patients were divided into the normal group and coagulopathy group based on prothrombin time (PT). The clinical characteristics of the two groups were compared using univariate analysis. The serum concentration threshold and influencing factors of CPZ-induced coagulopathy in critically ill patients were analyzed using the receiver operating characteristic (ROC) curve and multivariate logistic regression analysis.
Results
A total of 113 patients were included, and CPZ-induced coagulopathy occurred in 39 patients, with an incidence of 34.5%. These patients experienced significant PT prolongation around day 6 (median) after CPZ application. The serum trough concentration threshold of CPZ-induced coagulopathy in critically ill patients was 87.765 µg/ml. Multivariate logistic regression analysis revealed that the APACHE II score (p = 0.034), prophylactic use of vitamin K1 (p < 0.001), hepatic impairment (p = 0.014), and Cmin ≥ 87.765 µg/ml (p = 0.005) were associated with CPZ-induced coagulopathy.
Conclusion
CPZ-induced coagulopathy usually occurs on the 6th day of CPZ use in critically ill patients. The risk will increase in patients with an APACHE II score > 25, hepatic impairment, and CPZ Cmin ≥ 87.765 µg/ml. Vitamin K1 is effective in preventing this adverse reaction.
Evolutionary and Functional Roles of DNA Methylation in Human Senescence Regulation
Authors: Wu Yuke , Zhang Hanjie , Goto Hiroyuki , Kubota Yukihiko , Ito Masahiro 
Published: June 2023

Abstract
The regulation of human senescent protein expression is crucial for understanding the aging process. However, their evolutionarily acquired biological functions and relevance in diseases are poorly understood. Therefore, in this study, we performed an in silico analysis of 305 human senescent proteins, which were then categorized into five classes based on their evolutionary origins: chordates (Class 1: 104 proteins), metazoans (Class 2: 117 proteins), metazoans and plants (Class 3: 16 proteins), eukaryotes (Class 4: 58 proteins), and metazoans and fungi (Class 5: 10 proteins). Our findings suggest that senescence‐associated pathways were formed and became complexduring the evolution of chordates. During evolution, human senescent proteins played roles in nucleotide excision repair pathways, chemical carcinogenesis, and immune and cancer pathways. Differences in the average DNA methylation levels in the regulatory regions of genes that encode human senescent proteins were observed in proteins conserved in chordates, metazoans, and eukaryotes. In contrast, differences between the testes and ovaries were specifically observed for chordate-conserved proteins. We speculate that the precise modification of DNA methylation in the genes encoding key senescence‐associated pathways regulators, such as ERCC5/XPG, ACP1/PTP, CDKN1A/p21, and IFNB1, plays an important role in the development of the senescence‐associated pathway during evolution.
Molecular characterization of a novel narnavirus from the phytopathogenic fungus Botryosphaeria dothidea
Authors: Song Xinzheng , Zhang Jianing , Ma Qingzhou , Wang Yanfen , Guo Yashuang , Guo Lihua , Wu Haiyan , Zhang Meng 
Published: June 2023

Abstract
Here, a novel mycovirus, Botryosphaeria dothidea narnavirus 5 (BdNV5), was discovered in the plant-pathogenic fungus Botryosphaeria dothidea strain ZM210167-1. The BdNV5 genome sequence is 2,397 nucleotides (nt) in length and contains a putative open reading frame (ORF) encoding the RNA-dependent RNA polymerase (RdRp) with a molecular mass of 72.77 kDa. A BLASTp comparison of the RdRp sequence showed that it was most similar to the RdRp Botryosphaeria dothidea narnavirus 4 (42.35%). The phylogenetic tree based on RdRp sequence showed that BdNV5 clusters together with the members of the family Narnaviridae. BdNV5 is thus a novel member of the family Narnaviridae from the phytopathogenic fungus B. dothidea.
Development of surface and upper air synoptic catalogues for the Central Mediterranean and an application to the analysis of nitrogen dioxide in the Rome winter season.
Authors: Bird Danielle , Spellman Greg 
Published: June 2023

Abstract
Synoptic climatological approaches provide an effective framework for the analysis of atmospheric circulation patterns and the relationship with environmental variables. The objective circulation classification method of Jenkinson and Collison is applied to the central Mediterranean for the period 1948–2021. In order to capture more synoptic information a modified version of the method is used to also develop a series using the 500 hPa surface. Results capture key modes of variability of the Mediterranean atmosphere. The technique is used to examine variability in daily nitrogen dioxide (NO2) concentration in Rome. Analysis shows an evident surface synoptic control in the winter months and consideration of upper patterns renders this approach more effective.
Obesity hypoventilation syndrome with obstructive sleep apnea hypopnea syndrome leading to scrotal edema: a rare case report and literature review
Authors: Feng Yang , Zhao Qiaofei , Zhang Xianfen , Wang Xiangmeng , Han Wanqing 
Published: June 2023

Abstract
This paper reports a case of obese hypopnea syndrome combined with obstructive sleep apnea hypopnea syndrome, with "scrotal edema" as the main manifestation. Through multi-disciplinary consultation, the final diagnosis was made, and the patient was given positive airway pressure ventilation, diuresis, nutritional support and other comprehensive treatment. The patient finally turned well and discharged successfully.
In vitro antibacterial effect of three intra canal medicaments with or without electrophoresis on Enterocomlus faecalis at different dentin depths
Authors: Aminsobhani Mohsen , Azizlou Elaheh 
Published: June 2023

Abstract
Objective: Elimination of microorganisms from the root canal system plays a fundamental role in successful endodontic treatment. This study aimed to assess the antibacterial effect of three intra canal medicaments with/without electrophoresis on Enterococcus faecalis (E faecalis) at different dentin depths.
Materials and methods: This study evaluated 81 sound extracted single-rooted, single-canal human teeth. After root canal preparation, the teeth were sterilized, and E faecalis was inoculated into the root canals for 2 weeks. The teeth were then randomly divided into 9 groups (n=9) of (I) calcium hydroxide (CH) without electrophoresis, (II) CH with electrophoresis, (III) Cupral without electrophoresis, (IV) Cupral with electrophoresis, (V) silver nanoparticles (AgNPs) with CH without electrophoresis, (VI) AgNPs with CH and with electrophoresis, (VII) electrophoresis alone, (VII) negative control group, and (IX) positive control group. The medicaments were applied in the root canals and the teeth were incubated for 4 weeks. In electrophoresis groups, 15 mA electric current was applied for 6 min, and the teeth were then incubated. Then, dentin chips were collected from three different dentin depths by peeso reamers, and cultured on agar and thioglycolate culture media.
Results: No significant difference was noted in antimicrobial activity of tested materials at different depths (P>0.05). A significant difference was noted in elimination of microbial biofilm between groups with and without electrophoresis at depths 2 and 3 (P<0.05).
Conclusion: Electrophoresis resulted in greater penetration of medicaments into dentinal tubules, and enhanced their antimicrobial efficacy in deeper areas of dentinal tubules.
Clinical Relevance: Increasing the penetration of intra canal medicaments into the dentin increases their antimicrobial effect.
Investigating the safety of Fampridine in patients with different stages of multiple sclerosis
Authors: Bagherieh Sara , Farzan Mahour , Vaheb Saeed , Afshari-Safavi Alireza , Ebrahimi Narges , Shaygannejad Vahid , Mirmosayyeb Omid 
Published: June 2023

Abstract
Background: Fampridine is the only drug that was approved by US Food and Drug Administration (FDA) for patients with multiple sclerosis to improve their movement and has exhibited a clinically significant improvement in gait function in subset of multiple sclerosis patients with Expanded Disability Status scale (ESDSS) from 4 to 7. Nevertheless, this drug has been reported to possess some adverse effects like seizure due to its pharmacological features. The aim of this study was to evaluate the incidence rate of post-medication side effects of Fampridine on multiple sclerosis patients.
Method: This prospective cohort study includes MS patients aged between 18 years to 65 years, referred to neurology clinic of Kashani hospital from April 2022 to October 2022, all with administration of Fampridine (10mg tablet every 12 hours according to the product specifications) Safety in these patients is monitored through monthly side effects checklist questions during six months of screening. SPSS version 18 was used to analyze the data of this study.
Result: A total of 254 patients with multiple sclerosis, including 127 RRMS, 101 SPMS, and 26 PPMS patients, were included in the study. The most observed adverse effects in SPMS and RRMS patients were dry mouth (13.9% vs. 15%) and insomnia (12.9% vs. 11%), respectively. UTI (11.5%), and stomachache (11.5%) were the most common side effects in PPMS patients. The most severe complication of the patients was back pain, and digestive complications were less severe. Also, insomnia, and UTI were the patients' most persistent side effects.
Conclusion: The drug seems to be safe and well tolerated, as the side effects were mild and transient and they were similar with most of the previous studies focusing on this drug.
Assessment of complementary treatment with Yiqi Fumai lyophilized injection on acute decompensated ischemic heart failure (ACT-ADIHF): a multicenter randomized controlled trial
Authors: Wang Xianliang , Zhao Zhiqiang , Wang Xiaofeng , Deng Yue , Xu Yong , Zhang Hong , Tang Qiwei , Liu Zhongyong , Niu Tianfu , Wang Xiaolong , Wang Guanyu , Du Tinghai , Shang Shuzhong , Zhao Yingqiang , Zhao Xingsheng , Yan Xulong , Dai Xiaohua , Wang Yonggang , Xia Pu , Yuan Ruyu , Liu Chaofeng , Deng Bing , Fan Ruihong , Wang Liyue , Wu Huanlin , Dong Bo , Yu Hong , Zheng Meisheng , Wang Zhentao , Zhao Guoliang , Li Xin , Fan Huimin , Xie Ping , Mahemuti Ailiman , Li Zhiming , Liu Hongxu , Yang Junqiang , Zhao Mingjun , Tang E , Zhao Guoyuan , Wang Shuai , Zhong Chengliang , Hu Siyuan , Mao Jingyuan , Zhang Boli 
Published: June 2023

Abstract
Background
To evaluate the efficacy and safety of Yiqi Fumai lyophilized injection in treating acute decompensated ischemic heart failure (ADIHF).
Methods
666 patients with ADIHF from 37 clinical research centers in China were randomly allocated to the treatment group (n = 332) and the control group (n = 334). The control group was treated with standardized western medicine. The treatment group received intravenously 5.2g Yiqi Fumai lyophilized injection based on standardized western medicine for 7 days.
Results
There was no statistically significant difference in baseline characteristics between the two groups (P > 0.05). After treatment, the BNP level in the treatment group was significantly lower than that in the control group (8 days: 465.0 pg/ml vs. 533.6 pg/ml, P < 0.05; 60 ± 3 days: 398.0 pg/ml vs. 464.0 pg/ml, P < 0.01). The percentage of BNP level reduced by more than 30% compared to baseline was significantly higher in the treatment group than that in the control group (P < 0.01). And the improvement of LVEF, NYHA cardiac functional classification, MLHFQ score, and TCM four diagnosis information score were better in the treatment group than those in the control group at 60 ± 3 days after enrollment (P < 0.05 or P < 0.01). There were no statistically significant differences in the incidence of composite endpoint events and adverse events (P > 0.05).
Conclusion
Based on standardized western medicine, using Yiqi Fumai lyophilized injection can further reduce the plasma BNP level, improve cardiac function, alleviate clinical symptoms, improve the quality of life in patients with ADIHF, and it is safe.