bluuebunny/crossref_metadata_2025_split huggingface dataset:
CITRA PEREMPUAN PESANTREN DALAM NOVEL HATI SUHITA KARYA KHILMA ANIS
Authors: Shofiani Arisni Kholifatu Amalia 
Published: January 2023

Citra perempuan pesantren tidak melulu tentang citra yang menonojolkan dari segi syariat agama (Islam) saja namun dalam Novel Hati Suhita (HS) karya Khilma Anis )KA) juga memperlihatkan sisi Jawanya. Hal tersebutkan merupakan wujud representasi dari sang tokoh yaitu Alina Suhita yang mengggunakan syariat dan adat jawa untuk menentukan langkahnya. Fokus penelitian inia dalah citra perempuan pesantren sebagai seorang anak, dan citra perempuan pesantren sebagai seorang istri. Penelitian ini bertujuan untuk menemukan dan mendeskripsikan citra tokoh perempuan pesantren sebagai anak dan istri. Kajian yang digunakan dalam pene litian ini adalah representasi Stuart Hall dengan menggunakan metode deskriptif kualitatif dan hasil penelitian ini adalah Citra perempuan pesantren dalam Novel HS karya KA dilihat sebagai seorang anak dan istri akan menggunakan syariat agama dan budaya jawa yang telah dijunjungnya. Alina sangat sadar akan ilmunya nyantri dari kecil, namun dia tidak lupa juga untuk menggunakan petuah nenek moyangnya ataupun budaya jawa untuk mengambil sikap atau menentukan langkahnya.
HUBUNGAN POLA ASUH ORANG TUA DENGAN PERILAKU AGRESIF PADA ANAK PRA SEKOLAH DI TK AL HIDAYAH BAKUNG UDANAWU KABUPATEN BLITAR TAHUN 2022
Authors: Wigati Putri Wahyu , Sutrisni  , Akhmad  , Prasetyo Rudi Tri 
Published: January 2023

Pendahuluan : Pola asuh yang kurang tepat yang diterapkan oleh orang tua akan menciptakan situasi yang tidak menyenangkan bagi anak dan ini memicu distorsi anak reaksi atau perilaku terhadap lingkungannya. Jika suasana keluarga yang asing berlanjut, maka setiap perilaku anak akan terjebak dalam penyerapan nilai-nilai yang menyimpang dan perbuatan seperti perilaku agresif. Berdasarkan hasil survey awal didapatkan hasil 5 (50%) siswa yang mengalami perilaku agresif. Tujuan: untuk mengetahui hubungan pola asuh orang tua dengan perilaku agresif pada anak prasekolah di TK Al Hidayah Bakung Udanawu Kabupaten Blitar Tahun 2022. Metode: penelitian Infersial kuantitatif. Populasinya adalah semua orang tua (ibu) yang memiliki anak usia prasekolah yang berjumlah 124 orang dengan tekhnik Simple Random Sampling diperoleh sampel 94 responden. Hasil: Penelitian menunjukkan bahwa pola asuh yang diterapkan orang tua hamper setengahnya pola asuh demokratis 33 (35,1%), perilaku agresif pada anak prasekolah hamper setengahnya perilaku agresif tinggi 42 (44,6%). Berdasarkan hasil uji koefisien kontingengsi bahwa nilai p = 0,003 dengan ? = 0,05.sehingga p value < ?, maka ada hubungan antara pola asuh orang tua dengan Perilaku agresif pada anak prasekolah. Kesimpulan: Dari hasil penelitian ini diharapkan responden dapat memahami tentang pentingnya pola asuh orang tua sehingga dapat mencegah perilaku agresif pada anak prasekolah
HUBUNGAN INDEKS MASSA TUBUH DENGAN KEJADIAN ANEMIA PADA MAHASISWI TINGKAT 1 SARJANA KEPERAWATAN STIKES PEMKAB JOMBANG
Authors: Rodiyah Rodiyah 
Published: January 2023

Pendahuluan :.Remaja putri rentan menderita anemia karena banyak kehilangan darah pada saat menstruasi sehingga berisiko mengalami anemia pada saat hamil. Hal ini akan berdampak negatif terhadap pertumbuhan dan perkembangan janin dalam kandungan serta berpotensi menimbulkan komplikasi kehamilan dan persalinan, bahkan menyebabkan kematian ibu dan anak. Tujuan: untuk mengetahui apakah ada hubungan antara Indeks massa tubuh dengan kejadian anemia. Metode: Desain penelitian menggunakan analitik korelasional. Penelitian ini dilakukan pada mahasiswi sarjana keperawatan tingkat 1 Stikes Pemkab Jombang. Pengumpulan data meliputi pengukuran berat badan dan tinggi badan, pengukuran kadar Hb menggunakan Hb meter merek easy touch. Sampel yang digunakan sejumlah 47 sampel dengan menggunakan tehnik total sampling. Hasil: penelitian menunjukkan bahwa sebagian besar (51,1%) mempunyai IMT normal sejumlah 24 responden, hampir seluruhnya (76,6%) tidak anemia sejumlah 36 responden. Hasil uji statistic dengan Spearman Rank didapatkan PValue = 0,389 > ? = 0,05 artinya tidak ada hubungan antara Indeks massa tubuh dangan kejadian anemia. Kesimpulan: Diperlukan upaya promotif dan preventif untuk menanggulangi masalah anemia pada remaja seperti peningkatan konsumsi makanan kaya zat besi, suplementasi tablet tambah darah
HUBUNGAN DUKUNGAN KELUARGA DENGAN TINGKAT KECEMASAN PADA ANAK PENDERITA KANKER YANG MENJALANI KEMOTERAPI DI IRNA 4 RSUD dr. SAIFUL ANWAR MALANG
Authors: Hermono Tomy , Maria Lilla , Hariyanti Tanti Budhi 
Published: January 2023

Background : Cancer in children is one of the leading causes of death. Handling cancer in children will go through a series of chemotherapy treatment processes. In the preliminary study at RSUD dr. Saiful Anwar, approximately 80% of pediatric patients undergoing chemotherapy programs, mostly experience the psychological impact of anxiety.
Objective : The design of this study is an observational analytic method with a cross sectional approach which aims to analyze the relationship between the relationship between family support and anxiety levels in children undergoing chemotherapy.
Metodes: The sampling technique used purposive sampling on the parent population of cancer patients. The research instrument is a support questionnaire and an anxiety questionnaire (Zung Self Anxiety Rating Scale). Results : The results of the study obtained high family support as many as 56 respondents (83.6%), and the results showed that most patients with mild anxiety levels were 61 respondents (91%). Based on Spearman's statistical test, the r value of 0.356 (p value <0.05) showed that there was a weak relationship between family support and anxiety levels in cancer children undergoing chemotherapy. Therefore, families must be involved in mentoring during chemotherapy treatment in the hope of being able to have a positive impact during treatment.
UPAYA PENCEGAHAN STUNTING BERBASIS APLIKASI PERAN PENTING (PERAWAT DAN BIDAN PEDULI STUNTING) DI KABUPATEN JOMBANG
Authors: Andayani Sestu Retno Dwi , Maulidiyah Fadilatul Karomah , Imaningsih Agustin Nur , Fitria Nova Wilujeng 
Published: January 2023

Latar Belakang: Pemerintah menargetkan penurunan stunting menjadi 14 % ditahun 2020-2024. Penurunan Stunting menjadi prioritas pemerintah karena sangat mempengaruhi kualitas generasi muda. Diperlukan adanya kepedulian masyarakat untuk mendukung program pemerintah, melalui kader posyandu diharapkan bisa menurunkan stunting dengan bantuan perawat dan bidan dengan memanfaatkan android yang praktis dan mudah diakses oleh para kader posyandu. Tujuan: penelitian ini bertujuan untuk mengetahui pengaruh penggunaan aplikasi PERAN PENTING terhadap pengetahuan kader dalam memantau pertumbuhan dan gizi ibu maupun bayi. Metode: Jenis penelitian ini adalah pre-experiment dengan rancangan One Group Pretest Posttest Design. Variabel dalam penelitian ini adalah pengetahuan (variabel independent) dan aplikasi PERAN PENTING (variabel intervening). Teknik sampling yang digunakan adalah total sampling dengan Jumlah populasi sebanyak 19 jiwa. Analisa data dalam penelitian ini menggunakan uji Wilcoxon. Hasil: Hasil penelitian didapatkan nilai p=0,000 a (0,05), dengan 18 responden mengalami peningkatan. Kesimpulan: Dari data hasil tersebut dapat dikatakan bahwa Penggunaan Aplikasi PERAN PENTING berpengaruh terhadap peningkatan pengetahuan kader. Diskusi: Aplikasi PERAN PENTING memudahkan kader dalam mengakses informasi tentang stunting. Diperlukan adanya berbagai cara untuk memudahkan masyarakat dalam mencari informasi khususnya tentang Stunting.
Predatory efficiency of dragonfly nymphs, Crocothemis servilia and Rhyothemis variegata against the mosquito, Culex quinquefasciatus Say
Authors: Rahman Khondoker Md Zulfiker , Rahman Md Ashikur , Sharif Md Jillur , Mia Md Shohag , Kamal Md Mostafa , Razzak Mohammad Abdur , Bashar Kabirul 
Published: January 2023

This study compared the predatory potential of nymphs of two dragonfly species viz. Crocothemis servilia (Drury, 1773) and Rhyothemis variegata (Linnaeus, 1763) using the different larval instars and pupae of Cx. quinquefasciatus (Say, 1823) as preys in normal laboratory settings. Field-collected fed and 24 h starved nymphs of C. servilia and R. variegata were offered 1st, 2nd, 3rd and 4th instar larvae and pupae of Cx. quinquefasciatus to monitor the rate of predation. A 24 h starved nymph of C. servilia showed the highest predation on the 2nd instar larvae (92.00±4.06%) followed by the 3rd (83.00±5.61%), 4th (80±6.89%) and 1st (76.00±4.85%) instar larvae and the pupae (26.00±2.91), respectively, whereas, that of R. variegata exhibited the highest consumption of the 1st instar larvae (90.00±3.54 %) followed by the 2nd (88.00±5.61 %), 3rd (82.00±3.74 %), 4th (70.00±7.91 %) larval instar and the pupae (23.00±4.63), respectively within 24 h exposure. In the same period, the fed nymphs of C. servilia showed maximum consumption of the 2nd instar larvae (77.00±3.54%) followed by the 3rd (76.00±4.58%), 4th (64.00±4.00%) and 1st instar (55.00±3.53%) larvae and the pupae (24.00±3.67), respectively, whereas, that of R. variegata exhibited highest consumption of the 1st instar larvae (67.00±5.38 %) followed by the 2nd (65.00±10.12 %), 3rd (58.00±8.46 %) and 4th (53.00±4.06 %) instar larvae and the pupae (21.00±2.92), respectively. The rate of predation was significant on all the larval instars and the pupae compared to their control counterparts (p<0.05) and the starved larvae and nymphs of both the dragonfly species showed higher predation compared to the fed nymphs. The aforementioned findings suggest that nymphs of both of the dragonfly species exhibited considerable predation potential against the immature stages of the Cx. quinquefasciatus mosquito. The present study recommends assessing the feasibility of using these species in large-scale mosquito control programs.
Exploring the glass ceiling phenomenon among the recent female medical graduate of Bangladesh
Authors: Chowdhury Nadia Ireen , H Murshed , N Yasmen 
Published: January 2023

This was a descriptive type of cross sectional study conducted with an objective to find out the unacknowledged barrier to the advancement in medical profession of the recent female medical graduates of Bangladesh. The “glass ceiling” is a metaphor to convey the undefined obstacles that women and minorities face in the workplace. In this study, a self-administered, semi-structured questionnaire was used for data collection and also In-depth interviews were conducted to gain insight about the cause of drop out and to identify the barrier in academic progression and employment opportunities; along with the possible solution to overcome those obstacles. In this study, it was revealed that among the (817)recent female medical graduates only 12% were satisfied with their overall employment status while, majority (33.4%) were dissatisfied with their overall employment status. Of which extended work hour happens to main cause (68.8%) of their dissatisfaction. Regarding the Adequacy on the opportunity to enroll for post-graduation majority (47.9%) consider it to be inadequate. And also majorities (36.7%) are dissatisfied with their overall academic progression. Study has revealed many ways by which employment status can be improvised and can be made more female friendly, by starting ‘Day-care’ services in every working institute. Also by improving work environment and living environment at peripheral areas, ensuring more safety and security. Academic engagement can be improved by making exam center more accessible and by providing wide range of training scope.
Bangladesh Journal of Medical Education Vol.14(1) January 2023: 17-25
Heart rate variability in patients with obstructive sleep apnea and comorbid pathology
Authors: Tertyshnaya N. M. , Goldobin V. V. , Klocheva E. G. 
Published: January 2023

Aim. To study the features of heart rate variability in patients with obstructive sleep apnea (OSA) and comorbid pathology.Materials and methods. Polysomnography and registration of heart rate variability (HRV) were performed in 98 patients who applied to a neurologist.Results. Most of the HRV indicators in patients with OSA were significantly lower compared to the control group with orthostatic loading. The most notable of these were: TP (ms2), SDNN (ms), CV (%), HF (ms2), RMSSD (ms), DX (ms), LF (ms2). There were higher CI at rest (3.29 (1.53; 6.10), p = 0.034) and IVR (455.45 (286.95; 704.87), p = 0.014) during exercise in patients with OSA in comparison with the control group (1.73 (0.79; 3.93) and 344.00 (171.57; 440.87), respectively). It was found that arterial hypertension (94.6 %), chronic cerebral ischemia (80.4 %), and acute cerebrovascular accident (10.7 %) were significantly more common in patients with OSA than those examined without apnea (71.4 %, 42.9 % and 0.0 % respectively).Conclusions. BMI, neck volume, saturation level, and desaturation index can be considered as criteria for referring patients for HRV registration in order to assess the state of adaptive reserves. In patients with OSA, according to HRV indicators, a shift in the autonomic balance was found, which is expressed by a weakening of vagal influences and the degree of participation of the autonomic circuit in the regulation of heart rate with an increase in sympathetic orientation and central control mechanisms, a decrease in the body's adaptive resources. Work should be continued to clarify the contribution of comorbid pathology in patients with OSA to the development of autonomic dysfunction.
Carvacrol instigates intrinsic and extrinsic apoptosis with abrogation of cell cycle progression in cervical cancer cells: Inhibition of Hedgehog/GLI signaling cascade
Authors: Ahmad Afza , Tiwari Rohit Kumar , Saeed Mohd , Al-Amrah Hadba , Han Ihn , Choi Eun-Ha , Yadav Dharmendra K. , Ansari Irfan Ahmad 
Published: January 2023

Recent times have seen a strong surge in therapeutically targeting the hedgehog (HH)/GLI signaling pathway in cervical cancer. HH signaling pathway is reported to be a crucial modulator of carcinogenesis in cervical cancer and is also associated with recurrence and development of chemoresistance. Moreover, our previous reports have established that carvacrol (CAR) inhibited the proliferation of prostate cancer cells via inhibiting the Notch signaling pathway and thus, it was rational to explore its antiproliferative effects in cervical cancer cell lines. Herein, the present study aimed to investigate the anticancer and apoptotic potential of CAR on C33A cervical cancer cells and further explore the underlying mechanisms. We found that CAR significantly suppressed the growth of C33A cells, induced cell cycle arrest, and enhanced programmed cell death along with augmentation in the level of ROS, dissipated mitochondrial membrane potential, activation of caspase cascade, and eventually inhibited the HH signaling cascade. In addition, CAR treatment increased the expression of pro-apoptotic proteins (Bax, Bad, Fas-L, TRAIL, FADDR, cytochrome c) and concomitantly reduced the expression of anti-apoptotic proteins (Bcl-2 and Bcl-xL) in C33A cells. CAR mediates the activation of caspase-9 and -3 (intrinsic pathway) and caspase-8 (extrinsic pathway) accompanied by the cleavage of PARP in cervical cancer cells. Thus, CAR induced apoptosis by both the intrinsic and extrinsic apoptotic pathways. CAR efficiently inhibited the growth of cervical cancer cells via arresting the cell cycle at G0/G1 phase and modulated the gene expression of related proteins (p21, p27, cyclin D1 and CDK4). Moreover, CAR inhibited the HH/GLI signaling pathway by down regulating the expression of SMO, PTCH and GLI1 proteins in cervical carcinoma cells. With evidence of the above results, our data revealed that CAR treatment suppressed the growth of HPV−C33A cervical cancer cells and further elucidated the mechanistic insights into the functioning of CAR.
Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection
Authors: Qiu Peng , Yang Meng , Pu Hongji , Hou Jingli , Chen Xu , Wu Zhaoyu , Huang Qun , Huang Siyi , Fu Yan , Wen Zi'ang , Zhang Chengxin , Zha Binshan , Yang Yang , Xu Zhijue , Chen Fuxiang , Lu Xinwu 
Published: January 2023

Aim: Thoracic aortic dissection (TAD) is a high-risk vascular disease. The mortality rate of untreated TADs in 24 h was as high as 50%. Thus, rapid diagnosis of TAD in the emergency department would get patients to the right treatments to save their lives.Methods: We profiled the proteome of aortic tissues from TAD patients using a label-free quantification proteomics method. The differentially expressed proteins were screened and subjected to bioinformatics analysis. Candidate biomarkers were selected and validated in independent serum samples using enzyme-linked immunosorbent assays (ELISAs). The diagnostic values were further predicted via receiver operating characteristic (ROC) curve analysis.Results: A total of 1,141 differentially expressed proteins were identified in aortic tissues from 17 TAD patients and eight myocardial infarction (MI) patients. Six proteins were selected as candidate biomarkers for ELISAs in an independent training set of 20 serum samples (TAD = 10, MI = 10). Of these proteins, four with a P-value &lt; 0.01 were further validated in another independent set of 64 serum samples (TAD = 32, MI = 32) via ELISAs. ITGA2, COL2A1, and MIF had P-values &lt; 0.0001, and their areas under the curve (AUCs) were 0.801 (95% CI: 0.691–0.911), 0.773 (95% CI: 0.660–0.887), and 0.701 (95% CI: 0.574–0.828), respectively.Conclusion: ITGA2, COL2A1, and MIF were identified as promising biomarkers for discriminating TAD from emergency patients with severe chest pain. Biomarker-guided emergency triage could further shorten the time for patients to get more effective treatments.
Waist-to-height-ratio is associated with sustained hypertension in children and adolescents with high office blood pressure
Authors: Nimkarn Norrarath , Sewarit Anyamanee , Pirojsakul Kwanchai , Paksi Witchuri , Chantarogh Songkiat , Saisawat Pawaree , Tangnararatchakit Kanchana 
Published: January 2023

BackgroundWaist-to-height-ratio (WHtR) has been proposed as another indicator for cardiometabolic risk factors including hypertension. Normally, hypertension can be diagnosed in the office setting by detecting high blood pressure for three occasions. However, patients with high office blood pressure may not exhibit high blood pressure outside the office. Ambulatory blood pressure monitoring (ABPM) is a procedure to measure blood pressure over 24-h. Sustained hypertension is characterized as hypertension detected by both office measurement and ABPM. This study aimed to evaluate the performance of WHtR in the diagnosis of sustained hypertension in patients with high office blood pressure.Materials and methodsDemographic data, height, body weight, body mass index (BMI), and waist circumference were retrospectively reviewed in children and adolescents who underwent ABPM due to persistently high office blood pressure. Patients were separated into two groups: a sustained hypertension group and a normal ABPM group. BMI was adjusted to z-score using the WHO Anthroplus software. WHtR was calculated by the formula: waist circumference (cm)/height (m). The performances of different parameters were analyzed using the receiver operating characteristic (ROC) curve and multivariate logistic regression.ResultsSixty patients (63% male) with a mean age of 12.9 ± 3.7 years had persistently high office blood pressure. Twenty-nine (48.3%) had high ambulatory blood pressure parameters so-called “sustained hypertension.” The sustained hypertension group had a higher mean BMI z-score (2.32 vs. 1.31,p= 0.01) and a higher mean WHtR (57.7 vs. 49.2 cm/m,p&lt; 0.001) than those of the normal ABPM group. For the diagnosis of sustained hypertension, the ROC analysis revealed that WHtR had a greater area under the ROC curve (AUC) than that of BMI z-score (0.772 vs. 0.723). WHtR remained associated with sustained hypertension (OR 1.2, 95% CI 1.022–1.408,p= 0.026) after adjusting for age, gender, and BMI z-score.ConclusionsApart from being a more user-friendly metric, WHtR tended to outperform BMI z-score in predicting sustained hypertension in children and adolescents with persistently high office blood pressure.
Planning of graft size and 3D reconstruction using virtual reality technique in aortic valve reimplantation
Authors: Reid Gregory , Gehweiler Julian , Thieringer Florian , Eckstein Friedrich , Ferrari Enrico , Gahl Brigitta , Berdajs Denis A. 
Published: January 2023

ObjectivesTo evaluate applicability and feasibility of the virtual imaging technology for diagnosis and planning of the aortic valve sparing procedure.MethodsPre-operative electrocardiography-gated computed tomography images of 12 adult patients with aortic root pathology were used for 3D reconstruction of the aortic root geometry. The structural analysis was conducted with focusing on spatial architecture of key aortic root structures such as the three commissures, intervalvular triangles (IVT), as well as on morphology of the aortic root base (AoB) and of the sinotubular junction (STJ).ResultsIn all included patients, the 3D mapping of aortic root (AoR) morphology was successfully performed. The pre-operative diameter of the AoB was 30.6 ± 2.6 mm and of the STJ 46.5 ± 7.5 mm (p &lt; 0.001). Based on measured AoB diameter, the mean size of prosthesis used was 28.3 ± 1.37 mm. The planar arrangement of the three commissures was similar to an equilateral triangle where the three commissures were at similar distance for each individual sinus with 39.8 ± 6.64 mm for right, 37.5 ± 7.10 mm for left, and 39.2 ± 7.52 mm for non-coronary sinus (p = 0.72) subsequently. The similar height of the three IVT’s with 32.6 ± 5.87 mm for right, 33.6 ± 6.14 mm for anterior, and 31.7 ± 5.83 mm for left IVT (p = 0.73) was suggestive for all three commissures being positioned in the same plane. Consequently at reimplantation, the orientation of the three commissures followed the pattern of an equilateral triangle.ConclusionThe reconstructed images revealed a detailed 3D anatomy of the aortic root, with the spatial arrangement of the intervalvular triangles, planimetric orientation of the commissures, as well as determination of the AoB and STJ diameters. Obtained information was successfully applied to pre-operative surgical planning. The reimplantation technique, the height of the reimplanted intervalvular triangles, as well as their orientation are crucial for achieving adequate aortic valve function.