bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of noninvasive and disease-specific biomarkers in hereditary angioedema using urinary proteomics
Authors: Wu Jianqiang , Tang Xiaoyue , Wang Xue , Liu Peng , Zhou Nan , Zhang Zejian , Cao Yang , Zhang Shuyang , Zhi Yuxiang 
Published: January 2023

AbstractBackgroundHereditary angioedema (HAE) is a rare and potentially life-threatening disease. Noninvasive and disease-specific biomarkers are needed for the early diagnosis and clinical management of HAE.ObjectiveWe sought to apply untargeted proteomics profiling and targeted proteomics validation to identify pathogenic mechanisms and candidate biomarkers of HAE.MethodsData-independent acquisition (DIA)-based proteomics profiling was performed in urine samples of HAE patients and healthy controls. Bioinformatics analysis was used for functional annotation and pathway enrichment of differentially expressed proteins. Furthermore, promising biomarker candidates were validated in another independent clinical cohort using parallel reaction monitoring (PRM) targeted proteomics quantification.ResultsDifferent urinary proteomics profiles were identified among type 1 HAE, type 2 HAE and healthy controls. A total of 401 differentially expressed proteins were identified between type 1 HAE and healthy controls. Bioinformatics analysis showed that several biological processes and pathways were significantly enriched in HAE, including complement and coagulation cascades, cell adhesion molecules, immune response, proteolysis, and bradykinin catabolic process. Moreover, a promising biomarker panel (C1-INH, KNG1 and EGF) were validated in another independent clinical cohort. The area under the curve (AUC) value of this biomarker panel reached 0.910 for HAE diagnosis (sensitivity: 91.7, specificity: 88.9,P<0.001).ConclusionsThis study describes the first application of a DIA-PRM workflow to identify noninvasive and disease-specific biomarkers in HAE patients. These findings will contribute to the pathogenesis research and biomarker discovery of HAE.Key MessagesDifferent urinary proteomics profiles were identified among type 1 HAE, type 2 HAE and healthy controls.Several biological processes and pathways were significantly enriched in HAE, including complement and coagulation cascades, cell adhesion molecules, immune response, proteolysis, and bradykinin catabolic process.A urinary biomarker panel (C1-INH, KNG1, and EGF) could be a promising noninvasive diagnostic tool for HAE.
A comparison between early presentation of dementia with Lewy Bodies, Alzheimer’s disease and Parkinson’s disease: evidence from routine primary care and UK Biobank data
Authors: Nedelec Thomas , Couvy-Duchesne Baptiste , Darves-Bornoz Aube , Couronne Raphaël , Monnet Fleur , Gantzer Laurène , Lekens Béranger , Wu Yeda , Villain Nicolas , Schrag Anette , Durrleman Stanley , Corvol Jean-Christophe 
Published: January 2023

AbstractObjectiveTo simultaneously contrast prediagnostic clinical characteristics of individuals with a final diagnosis of dementia with Lewy Bodies, Parkinson’s disease, Alzheimer’s disease compared to controls without neurodegenerative disorders.MethodsUsing the longitudinal THIN database in the UK, we tested the association of each neurodegenerative disorder with a selected list of symptoms and broad families of treatments, and compared the associations between disorders to detect disease-specific effects. We replicated the main findings in the UK Biobank.ResultsWe used data of 28,222 patients with PD, 20,214 with AD, 4,682 with DLB and 20,214 controls. All neurodegenerative disorders were significantly associated with the presence of multiple clinical characteristics before their diagnosis including sleep disorders, falls, psychiatric symptoms and autonomic dysfunctions. When comparing DLB patients with patients with PD and AD patients, falls, psychiatric symptoms and autonomic dysfunction were all more strongly associated with DLB in the five years preceding the first neurodegenerative diagnosis. The use of statins was lower in patients who developed PD and higher in patients who developed DLB compared to AD. In PD patients, the use of statins was associated with the development of dementia in the five years following PD diagnosis.InterpretationPrediagnostic presentations of falls, psychiatric symptoms and autonomic dysfunctions were more strongly associated with DLB than PD and AD. This study also suggests that whilst several associations with medications are similar in neurodegenerative disorders, statin usage is negatively associated with Parkinson’s Disease but positively with DLB and AD as well as development of dementia in PD.
Behavior-change interventions to improve antimicrobial stewardship in human health, animal health, and livestock agriculture: A systematic review
Authors: Craig Jessica , Sadoff Rachel , Bennett Sarah , Bahati Felix , Beauvais Wendy 
Published: January 2023

AbstractAntimicrobial resistance (AMR) is an economic, food security, and global health threat that is driven by a multitude of factors including the overuse and misuse of antimicrobials in the human health, animal health, and agriculture sectors. Given the rapid emergence and spread of AMR and the relative lack of development of new antimicrobials or alternative therapies, there is a need to develop and implement non-pharmaceutical AMR mitigation policies and interventions that improve antimicrobial stewardship (AMS) practices across all sectors where antimicrobials are used. We conducted a systematic literature review per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify peer-reviewed studies that described behavior-change interventions that aimed to improve AMS and/or reduce inappropriate antimicrobial use in the human health, animal health, and livestock agriculture stakeholders. We identified 301 total publications – 11 in the animal health sector and 290 in the human health sector – and assessed these interventions using metrics across five thematic areas- (1) antimicrobial use (AMU), (2) adherence to clinical guidelines, (3) AMS, (4) AMR, and (5) clinical outcomes. The lack of studies in the animal health sector precluded a meta-analysis. Among studies in the human health sector, 35.7% reported significant (p<0.05) pre- to post-intervention decreases in AMU, 73.7% reported significant improvements in adherence of antimicrobial therapies to clinical guidelines, 45% demonstrated significant improvements in AMS practices, 45.5% reported significant decreases in the proportion of isolates that were resistant to antibiotics or the proportion of patients with drug-resistant infections across 17 antimicrobial-organism combinations, and few studies reported statistically significant changes in clinical outcomes. We did not identify any overarching intervention type nor characteristics associated with successful improvement in AMS, AMR, AMU, adherence, nor clinical outcomes.
Sequential unfolding mechanisms of monomeric caspases
Authors: Joglekar Isha , Clark A. Clay 
Published: January 2023

AbstractCaspases are evolutionarily conserved cysteinyl proteases that are integral in cell development and apoptosis. All apoptotic caspases evolved from a common ancestor into two distinct subfamilies with either monomeric (initiators) or dimeric (effectors) oligomeric states. The regulation of apoptosis is influenced by the activation mechanism of the two subfamilies, but the evolution of the well-conserved caspase-hemoglobinase fold into the two subfamilies is not well understood. We examined the folding landscape of monomeric caspases from two coral species over a broad pH range of 3 to 10.5. On an evolutionary timescale, the two coral caspases diverged from each other approximately 300 million years ago, and they diverged from human caspases about 600 million years ago. Our results indicate that both proteins have overall high stability, ∼ 15 kcal mol-1near the physiological pH range (pH 6 to pH 8), and unfold via two partially folded intermediates, I1and I2, that are in equilibrium with the native and the unfolded state. Like the dimeric caspases, the monomeric coral caspases undergo a pH-dependent conformational change resulting from the titration of an evolutionarily conserved site. Data from molecular dynamics simulations paired with limited proteolysis and MALDI-TOF mass spectrometry show that the small subunit of the monomeric caspases is unstable and unfolds prior to the large subunit. Overall, the data suggest that all caspases share a conserved folding landscape, that a conserved allosteric site can be fine-tuned for species-specific regulation, and that the subfamily of stable dimers may have evolved to stabilize the small subunit.
Identification of the Bravais lattice and cell parameters through quantitative model-based transmission electron microscopy and Niggli cell reduction theory: the case of intermetallic Ni5Pb2Te3
Authors: Kumar Dipanjan , Ravishankar N. , Chattopadhay Kamanio 
Published: January 2023

This article demonstrates a simple and effective way to accurately determine the Bravais lattice type and cell parameters of an unknown phase by combining quantitative model-based high-resolution (scanning) transmission electron microscopy and Niggli cell reduction theory. This method was applied to the Ni5Pb2Te3 phase in the Ni–Pb–Te ternary system, which exists at high temperatures and forms from the interaction of Ni contacts with PbTe thermoelectric materials. The structure was identified to be triclinic with the space group P1 and cell parameters a = 5.43 ± 0.09 Å, b = 3.93 ± 0.03 Å, c = 3.75 ± 0.01 Å, α = 115.4 ± 0.2°, β = 93.4 ± 0.6° and γ = 91.1 ± 0.1°. The methodology is particularly beneficial for the class of problems where the phase under study coexists in a multiphase environment.
Hearing the voice of child welfare social workers: planning safe care for a child with or suspected of having fetal alcohol spectrum disorders (FASDs)
Authors: Curran William Christopher , Danbrook Matthew C. 
Published: January 2023

Purpose
In the early 1970s, clinical evidence emerged documenting causal links between prenatal alcohol exposure (PAE) and children’s behaviors as observed by child welfare social workers (CWSWs). Unfortunately, fetal alcohol spectrum disorders (FASD) remain on the margins of public health priorities. The purpose of this study was to elicit the views of child welfare social workers when responding to case of or suspected FASD.

Design/methodology/approach
A sample (N = 18) of CWSWs, allied health professionals and foster parents were interviewed.

Findings
Findings indicate that social workers struggle with their statutory duty to plan safe care for children with or suspected of having FASD. Emergent themes include struggling with advocacy, professional devaluation and lack of procedural guidance.

Practical implications
Social workers need a clear pathway and FASD knowledge to guide their interventions and enhance their capacity to advocate for affected children.

Originality/value
An abundance of research documents the direct effect of PAE on physical, cognitive and behavioral outcomes. However, few studies focus on the critical interface of children with an FASD entering public care and the social workers responsible for planning their safe care. This study sought to document social workers’ response to this vulnerable cohort of children.
Political–economic instability and earnings management in an emerging market: the case of the 2016 Presidential Impeachment in Brazil
Authors: Andrade Douglas , Viana Dante , Ponte Vera , Domingos Sylvia 
Published: January 2023

PurposeThis study analyzes earnings management among Brazilian public firms during the 2016 Presidential Impeachment.Design/methodology/approachThe sample comprises, as a treatment group, 721 firm-quarter observations relating to Brazilian listed firms. It also considers a control group of listed firms from Mexico, which were not affected by the exogenous shock analyzed (i.e. the 2016 Presidential Impeachment in Brazil). The firms' quarterly financial data cover the period between 2013 and 2018.FindingsConsidering several proxies related to earnings management by accruals, the main findings suggest a negative relationship between the 2016 impeachment event and the level of discretionary accruals, suggesting that Brazilian firms tended to reduce their earnings management levels during the impeachment process. The results are robust whether the control group is considered or not.Originality/valueThis study brings new empirical evidence to the literature on accounting information quality about the role of the economic and political environment in earnings management, especially in weak institution countries characterized by institutional voids and higher levels of corruption.
Exploring the readiness of a Brazilian technological university during the COVID-19 pandemic
Authors: Scur Gabriela , Alliprandini Dario H. , Chinaglia Eliane F. , Santos Roberto Baginski Batista 
Published: January 2023

PurposeThe paper investigates the learning practices carried out by Higher Education Institutions (HEIs) in the transition from strictly face-to-face to remote teaching in response to the coronavirus disease 2019 (COVID-19) pandemic. It also analyses how these practices could be used as a baseline to support new perspectives on learning in the technological education field.Design/methodology/approachThe authors conducted a single-case study of a Brazilian technological university.FindingsThis study’s findings indicate that institutional planning and providing support to faculty and students were essential measures for a successful transition from face-to-face teaching to emergency remote teaching. Planning includes careful selection by the HEI of the tools that make a virtual learning environment and the strategies used to replace face-to-face teaching with emergency remote teaching. Our study points out the lessons learned during the pandemic. It presents guidelines for HEIs on how to prepare for a return to face-to-face teaching, embodying some learning dimensions such as synchronous or asynchronous, active or passive, individual or collective, and mediated or not mediated by information and communication technologies (ICTs).Originality/valueThe paper provides reflections on the four dimensions to support decisions to leverage learning in each educational institution. This paper's main contribution is that the concept of teaching and learning must be comprehensive and inclusive according to the particular HEI context.
The role of marketing agility and risk propensity in resilience and survival of eastern European immigrant entrepreneurs in Denmark
Authors: Golgeci Ismail , Arslan Ahmad , Kentosova Veronika , Callaghan Deborah , Pereira Vijay 
Published: January 2023

PurposeWhile extant research has increasingly examined minority entrepreneurs, less attention has been paid to Eastern European immigrant entrepreneurs and the role that marketing agility and risk propensity play in their resilience and survival in Nordic countries. This paper aims to highlight the importance of these factors for Eastern European immigrant entrepreneurs in the developed Nordic economy of Denmark.Design/methodology/approachThis paper adopts the dynamic capabilities view as a theoretical framework and uses a qualitative research approach with interviews as the main data collection method. The empirical sample comprises 12 entrepreneurs originating from Hungary, Slovakia, Latvia, Lithuania and Romania, who operate in Denmark.FindingsThe findings show that contrary to prior studies that have highlighted a reliance among the migrant entrepreneurial community on ethnic networks as their dominant target market, Eastern European immigrant entrepreneurs located in Denmark, in contrast, focused on attracting Danish consumers as their target market audience. Leveraging multiple networks was therefore found to be critical to the survival of these immigrant ventures. Additionally, the entrepreneurs' marketing agility, underpinned by their optimistic approach, growth ambitions and passion for entrepreneurship, was found to play a pivotal role in their survival. Finally, despite the stable institutional environment in Denmark and the ease of doing business (both of which are influential factors in shaping the risk propensity and risk perception of entrepreneurs), the authors found immigrant entrepreneurs' risk propensity to be rather low, which was contrary to the expectations.Originality/valueThe current paper is one of the first studies that explicitly analyzes the roles of marketing agility and risk propensity in the resilience and survival of the ventures of relatively skilled immigrant entrepreneurs from Eastern Europe in a developed Nordic economy (Denmark). The paper's findings also challenge the notion associated with immigrant entrepreneurial ventures being primarily focused on ethnic customers or enclaves. The paper also specifies the peculiarities of marketing agility in immigrant entrepreneurial contexts and solidifies the importance of diverse networks in immigrant business survival and development.
Assessment of energy efficiency investment in Onitsha business cluster, Nigeria
Authors: Dimnwobi Stephen Kelechi , Nwokoye Ebele Stella , Igbanugo Clement Izuchukwu , Ekesiobi Chukwunonso Sylvester , Asongu Simplice A. 
Published: January 2023

Purpose
This paper empirically assesses energy efficiency (EE) adoption among firms by examining the factors that drive investment in EE in the Onitsha plastic cluster, South-East, Nigeria.

Design/methodology/approach
Self-administered questionnaires were delivered to the selected enterprises. A total of 450 questionnaires were administered of which 423 were certified valid and used for the analysis. A Heckit model was developed and estimated.

Findings
Gender, firm size, Joneses effect and expected cost reduction benefits are the significant determinants of EE investment. However, firm structure, government incentives, regulatory requirements and reduction of carbon emission are insignificant drivers of EE investment decisions in the Onitsha plastic cluster.

Originality/value
This paper presents a foremost attempt at analysing the determinants of energy investment in a cluster in Nigeria.
How do food supply chain performance measures contribute to sustainable corporate performance during disruptions from the COVID-19 pandemic emergency?
Authors: Le Thanh Tiep 
Published: January 2023

PurposeThis study aims to the development of the scale of supply chain performance measures (SCPMs), food supply chain resilience (FSCS) and sustainable corporate performance (SCP) in small- and medium-sized enterprises (SMEs) in an emerging market. Based on this purpose, the study examines the relationships between SCPMs and SCP by exploring the mediating role of FSCS in emerging markets.Design/methodology/approachBased on a comprehensive literature review on the SCPMs, FSCS and SCP, the author evaluates the nexus of these constructs on disruptions during the COVID-19 pandemic emergency in an emerging market. The article follows a quantitative approach. A total of 567 valid responses from managers at senior and middle levels were received and used for data analysis. The Smart PLS version 3.3.2 was employed to analyse Structural Equation Modelling (SEM) to investigate the relationships between constructs and latent variables.FindingsThis study provides some theoretical contributions to expand the extant literature on the domain of SCPMs. First, the findings determine that multidimensional measures of flexibility, diversity, agility, inventory efficiency, redundancy and robustness are appropriate for measuring food SC performance in disruptions during the COVID-19 emergency. Besides, this study enriches the existing literature on SC disruption by providing extensive empirical evidence on SCPMs in disruptions during the COVID-19 emergency. Finally, this research provides an integrated empirical model that explores the link between the identified food SCPMs to FSCS and SCP.Originality/valueThe contributions may be of interest to business practitioners, business leaders and academics. In addition, this study provides empirical evidence to demonstrate that food SC performance, as measured by these measures, is strongly related to the firm's food supply chain resilience. This is the novel contribution of this study to the current literature on food SC management. Furthermore, this study provides further empirical evidence demonstrating the partial mediating role of the firm's food supply chain resilience in the nexus between food SC performance and SCP. The unique contribution of this study is an extension of the body of knowledge of SC management literature from a comprehensive approach by providing a proven set of performance measures of SC management to which it can drive SC resilience and SCP for food manufacturing SMEs in an emerging economy that hardly found in the current literature.
From recycling to sustainability principles: the perceptions of undergraduate students studying early childhood education of an education for sustainability course
Authors: Gal Adiv 
Published: January 2023

Purpose
This study aims to examine the perceptions of undergraduate students studying early childhood education who took an academic course in which transformative pedagogy is adopted as part of a holistic approach designed to create transformative change and strengthen the students’ self-efficacy for sustainability, and thus, help reduce the environmental crisis in which we live.

Design/methodology/approach
By means of a phenomenological approach, this exploratory qualitative research used three research tools, reflection analysis, drawing analysis and analysis of course summary work, to identify changes in the perceptions of students undertaking the course. Data analysis was based on an inductive approach and included first- and second-cycle coding.

Findings
The results of the study show that the transformative pedagogy adopted in the course created transformative change in the students’ knowledge, attitudes, emotions and self-efficacy to act to reduce the climate crisis, not just through recycling.

Research limitations/implications
The study was conducted with a relatively small, single class of undergraduate early childhood education students. The impact of certain activities may be different in larger classes. The gender imbalance, with the majority of students being female adds a further limitation. Male students may have different perspectives than female students, and those with different backgrounds and interests may respond differently.

Practical implications
This study provides some important insights into how sustainability education can be applied in a higher education curriculum. The study also contributes to the current dialogue on sustainability education by providing a rich description of how students experience alternative approaches to teaching in the field.

Originality/value
This study demonstrates how environmental action can be integrated in higher education.
A bibliometric review of research in wine tourism experiences: insights and future research directions
Authors: Kotur Anupama S. 
Published: January 2023

Purpose
This paper aims to systematically map the nature of research in the field of wine tourism experiences and suggest research agenda based on the thematic mapping.

Design/methodology/approach
A total of 112 articles on wine tourism experiences published between 2000 and 2022 from Scopus and Web of Science databases were analysed. Bibliometric analyses, namely, performance analysis and science mapping, were done using Biblioshiny, an R-tool.

Findings
The results indicate that post-2015, the subject diversified into specialised sub-themes and empirical studies were widely adopted research methods. International Journal of Wine Business Research emerged as a leading outlet for scholarly publications. The study recommends key research themes for future research in the area.

Originality/value
To the best of the author’s knowledge, this is the first bibliometric analysis-based study on wine tourism experiences. The research agenda discussed can help initiate scholarly discussions in this area.