bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of extracellular vesicles derived from follicular fluid of women with and without PCOS: integrating analysis of differential miRNAs and proteins reveals vital molecules involving in PCOS
Authors: Yang Yuqin , Lang Peng , Zhang Xiaolan , Wu Xun , Cao Shanren , Zhao Chun , Shen Rong , Ling Xiufeng , Yang Ye , Zhang Junqiang 
Published: January 2023

Abstract
Purpose
To elucidate the characterization of extracellular vesicles (EVs) in the follicular fluid-derived extracellular vesicles (FF-EVs) and discover critical molecules and signaling pathways associating with the etiology and pathobiology of PCOS, the differentially expressed miRNAs (DEmiRNAs) and differentially expressed proteins profiles (DEPs) were initially explored and combinedly analyzed.

Methods
First, the miRNA and protein expression profiles of FF-EVs in PCOS patients and control patients were compared by RNA-sequencing and tandem mass tagging (TMT) proteomic methods. Subsequently, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes were used to analyze the biological function of target genes of DEmiRNAs and DEPs. Finally, to discover the functional miRNA-target gene-protein interaction pairs involved in PCOS, DEmiRs target gene datasets and DEPs datasets were used integratedly.

Results
A total of 6 DEmiRNAs and 32 DEPs were identified in FF-EVs in patients with PCOS. Bioinformatics analysis revealed that DEmiRNAs target genes are mainly involved in thiamine metabolism, insulin secretion, GnRH, and Apelin signaling pathway, which are closely related to the occurrence of PCOS. DEPs also closely related to hormone metabolism processes such as steroid hormone biosynthesis. In the analysis integrating DEmiRNAs target genes and DEPs, two molecules, GRAMD1B and STPLC2, attracted our attention that are closely associated with cholesterol transport and ceramide biosynthesis, respectively.

Conclusion
Dysregulated miRNAs and proteins in FF-EVs, mainly involving in hormone metabolism, insulin secretion, neurotransmitters regulation, adipokine expression, and secretion, may be closely related to PCOS. The effects of GRAMD1B and STPLC2 on PCOS deserve further study.
Applying MAPE-K control loops for adaptive workflow management in smart factories
Authors: Malburg Lukas , Hoffmann Maximilian , Bergmann Ralph 
Published: January 2023

AbstractMonitoring the state of currently running processes and reacting to ad-hoc situations during runtime is a key challenge in Business Process Management (BPM). This is especially the case in cyber-physical environments that are characterized by high context sensitivity. MAPE-K control loops are widely used for self-management in these environments and describe four phases for approaching this challenge: Monitor, Analyze, Plan, and Execute. In this paper, we present an architectural solution as well as implementation proposals for using MAPE-K control loops for adaptive workflow management in smart factories. We use Complex Event Processing (CEP) techniques and the process execution states of a Workflow Management System (WfMS) in the monitoring phase. In addition, we apply automated planning techniques to resolve detected exceptional situations and to continue process execution. The experimental evaluation with a physical smart factory shows the potential of the developed approach that is able to detect failures by using IoT sensor data and to resolve them autonomously in near real time with considerable results.
Influence of manganese ions in calcium silicate glass–ceramics on optical, mechanical, and magnetic properties
Authors: Mahdy Manal A. , Hamzawy Esmat M. A. , El-Bassyouni Gehan T. , Zawawi I. K. El , Sherif H. H. A. 
Published: January 2023

AbstractNanocrystalline calcium silicate powder was synthesized by adding different ratios of MnO2 ranging from 0.00 to 2.00 wt% to detect its effect on the structure and physical properties. The pseudowollastonite triclinic and low combeite of hexagonal phase with nanocrystallite size less than 85.0 nm were confirmed by the XRD technique and average particle size ranging from 7.8 to 27.9 nm as detected by HR-TEM micrograph images. Stretching and bending vibration of the O–Si–O band were shifted to higher values upon the addition of MnO2 were verified by FT-IR. Increasing both the density and ultimate strength with a reduction in the porosity leads to an improvement in the mechanical properties with the addition of MnO2. Additionally, the increasing MnO2 content showed an improvement in magnetic and optical properties, which exhibited a decrement in the optical band gap Eg from 3.9 to 1.6 eV. Hence, the MnO2 acts as a structural network modifier of calcium silicate glass–ceramics. Furthermore, the estimated values of the Lande g-factor (2.01534–2.01731) for the d5 system of the Mn2+ displayed a negative shift from the free electron (2.0023), and the hyperfine splitting constant A value was 87 × 10−4 cm−1, indicating that the Mn2+ ions are in an ionic environment.
ZnO/Ag multilayer for enhancing the catalytic activity against 4-nitrophenol
Authors: Mostafa Ayman M. , Mwafy Eman. A. , Khalil Ahmed M. , Toghan Arafat , Alashkar Emad A. 
Published: January 2023

AbstractA multilayer thin film from zinc oxide and silver (ZnO/Ag multilayer thin film) has been synthesized via the technique of pulsed infrared laser deposition at 600 °C to be used as a portable catalyst for the degradation of 4-nitrophenol. The multilayer thin film was formed by two steps; the first one was making a thin film with a 300 nm thickness, followed by a 100 nm thin film from Ag, which was characterized by different characterization techniques. The XRD data demonstrated the presence of hexagonal Ag on ZnO in the formation of ZnO thin films and ZnO/Ag thin films. Also, it showed that crystallite size is decreasing as the Ag concentration rises because of the difference in atomic radius between Zn and Ag atoms in the crystal structure formation of ZnO coated with Ag. The crystal quality of ZnO and Ag was evaluated using photoluminescence (PL). The optical investigation showed the decrease in transmittance after coating ZnO film with Ag was due to ZnO films including more voids than ZnO/Ag films. From SEM images, the morphology of ZnO films was modified by the appearance of brilliant spots, which was related to the coating of the Ag layer as confirmed by elemental analysis. Then, based on the findings of catalytic experiments against 4-nitrophenol, the ZnO/Ag multilayer thin film shows an exceptional potential enhancement in compared to that of ZnO thin film.
An oracle-based framework for robust combinatorial optimization
Authors: Bettiol Enrico , Buchheim Christoph , De Santis Marianna , Rinaldi Francesco 
Published: January 2023

AbstractWe propose a general solution approach for min-max-robust counterparts of combinatorial optimization problems with uncertain linear objectives. We focus on the discrete scenario case, but our approach can be extended to other types of uncertainty sets such as polytopes or ellipsoids. Concerning the underlying certain problem, the algorithm is entirely oracle-based, i.e., our approach only requires a (primal) algorithm for solving the certain problem. It is thus particularly useful in case the certain problem is well-studied but its combinatorial structure cannot be directly exploited in a tailored robust optimization approach, or in situations where the underlying problem is only defined implicitly by a given software. The idea of our algorithm is to solve the convex relaxation of the robust problem by a simplicial decomposition approach, the main challenge being the non-differentiability of the objective function in the case of discrete or polytopal uncertainty. The resulting dual bounds are then used within a tailored branch-and-bound framework for solving the robust problem to optimality. By a computational evaluation, we show that our method outperforms straightforward linearization approaches on the robust minimum spanning tree problem. Moreover, using the Concorde solver for the certain oracle, our approach computes much better dual bounds for the robust traveling salesman problem in the same amount of time.
Quantum similarity and QSPR in Euclidean-, and Minkowskian–Banach spaces
Authors: Carbó-Dorca Ramon 
Published: January 2023

AbstractThis paper describes first how Euclidian- and Minkowskian–Banach spaces are related via the definition of a metric or signature vector. Also, it is discussed later on how these spaces can be generated using homothecies of the unit sphere or shell. Such possibility allows for proposing a process aiming at the dimension condensation in such spaces. The condensation of dimensions permits the account of the incompleteness of classical QSPR procedures, independently of whether the algorithm used is statistical bound or AI-neural network related. Next, a quantum QSPR framework within Minkowskian vector spaces is discussed. Then, a well-defined set of general isometric vectors is proposed, and connected to the set of molecular density functions generating the quantum similarity metric matrix. A convenient quantum QSPR algorithm emerges from this Minkowskian mathematical structure and isometry.
The Gestural Misinformation Effect in Child Interviews in Switzerland
Authors: Meyer Kendra Rita , Blades Mark , Krähenbühl Sarah 
Published: January 2023

AbstractGestures embody concepts in the form of universal representations. Researchers have highlighted that social communication often embodies nonverbal behavior. A forensic interviewer’s nonverbal behavior, such as gesturing during an interview, could communicate misleading information and may cause inaccuracies in the interviewees’ testimonies. The current study was conducted in Switzerland and included 108 child participants, in three age groups (a younger sample aged 6–9 years, n = 32) (a middle sample aged 10–11 years, n = 40) and an older sample aged 12–13 years, n = 36). Participants viewed a video and completed an interview about the video, individually, immediately after. During the questioning, the interviewer deliberately misled the interviewees with nonverbal gestures. The results showed that 95 children were misled by at least one gesture and that gestures led to a significant decrease in accuracy. Children also incorporated misleading gestures and reported false information; adding to existing evidence that misinformation can also be communicated through nonverbal gestures. Our findings demonstrate the negative influence of misleading gestures in child eyewitness interviews and provide more evidence for the robustness of the gestural misinformation effect, reported in previous research.
Autoencoding slow representations for semi-supervised data-efficient regression
Authors: Struckmeier Oliver , Tiwari Kshitij , Kyrki Ville 
Published: January 2023

AbstractThe slowness principle is a concept inspired by the visual cortex of the brain. It postulates that the underlying generative factors of a quickly varying sensory signal change on a different, slower time scale. By applying this principle to state-of-the-art unsupervised representation learning methods one can learn a latent embedding to perform supervised downstream regression tasks more data efficient. In this paper, we compare different approaches tounsupervised slow representation learningsuch as$$L_p$$Lpnorm based slowness regularization and the SlowVAE, and propose a new term based on Brownian motion used in our method, the S-VAE. We empirically evaluate these slowness regularization terms with respect to their downstream task performance and data efficiency in state estimation and behavioral cloning tasks. We find that slow representations show great performance improvements in settings where only sparse labeled training data is available. Furthermore, we present a theoretical and empirical comparison of the discussed slowness regularization terms. Finally, we discuss how the Fréchet Inception Distance (FID), commonly used to determine the generative capabilities of GANs, can predict the performance of trained models in supervised downstream tasks.
Curcumin-resveratrol nano-formulation counteracting hyperammonemia in rats
Authors: Nasr Maha , Ahmed-farid Omar A.H. , Ahmed Rania F. 
Published: January 2023

AbstractMalnutrition and low dietary protein intake could be risk factors for developing peripheral and central hyperammonemia, especially in pediatrics. Both curcumin and resveratrol proved to be effective against several hepatic and cerebral injuries. They were reported to be beneficial in lowering circulating ammonia levels, yet both are known for their low bioavailability. The use of pharmaceutical nano-formulations as delivery systems for these two nutraceuticals could solve the aforementioned problem. Hence, the present study aimed to investigate the valuable outcome of using a combination of curcumin and resveratrol in a nanoemulsion formulation, to counteract protein-deficient diet (PDD)-induced hyperammonemia and the consequent complications in male albino rats. Results revealed that using a nanoemulsion containing both curcumin and resveratrol at a dose of (5 + 5 mg/kg) effectively reduced hepatic and brain ammonia levels, serum ALT and AST levels, hepatic and brain nitric oxide levels, oxidative DNA damage as well as disrupted cellular energy performance. In addition, there was a substantial increase in brain levels of monoamines, and a decrease in glutamate content. Therefore, it can be concluded that the use of combined curcumin and resveratrol nanoemulsion is an effective means of ameliorating the hepatic and cerebral adverse effects resulting from PDD-induced hyperammonemia in rats.
A Systematic Review of Cognition in Cervical Dystonia
Authors: O’Connor Sarah , Hevey David , Burke Tom , Rafee Shameer , Pender Niall , O’Keeffe Fiadhnait 
Published: January 2023

AbstractGrowing evidence points to a spectrum of non-motor symptoms, including cognitive difficulties that have a greater impact on functional outcomes and quality of life than motor symptoms in cervical dystonia (CD). Some cognitive impairments have been reported; however, findings are inconsistent, and described across mixed groups of dystonia. The current review aimed to examine the evidence for cognitive impairments in CD. MEDLINE, EMBASE, PsychINFO and Web of Science databases were searched. Studies were included if they met the following criteria (i) cross-sectional or longitudinal studies of adults with CD, (ii) where the results of standardised measures of cognitive or neuropsychological function in any form were assessed and reported, (iii) results compared to a control group or normative data, and (iv) were published in English. Results are presented in a narrative synthesis. Twenty studies were included. Subtle difficulties with general intellectual functioning, processing speed, verbal memory, visual memory, visuospatial function, executive function, and social cognition were identified while language, and attention and working memory appear to be relatively spared. Several methodological limitations were identified that should be considered when interpreting the evidence to describe a specific profile of cognitive impairment in CD. Clinical and research implications are discussed.
Models for Reactions in Confined Space: Can Surface Science Contribute? A Review and Perspective
Authors: Gura L. , Soares E. A. , Paier J. , Stavale F. , Freund H.-J. 
Published: January 2023

AbstractThis paper reports and discusses some of our recent advances in surface science research on a silica film supported on a Ru(0001) substrate. This system is unique, as the silica is bound to the metal surface by dispersive forces only, and thus opens the possibility to study reactions in the confined space between the metal substrate and the silica film, acting as a permeable membrane. We demonstrate that this system allows for detailed insights into the complexity of reactions in confined space, including phenomena due to the response of the confined space to the presence of the reactants, and direct comparison to the situation when the same reaction occurs in open space.
A Preliminary Study on the Sustainability of Metallization of Polymer Matrix Composites through Cold Spray
Authors: Viscusi Antonio , Perna Alessia Serena , Astarita Antonello 
Published: January 2023

AbstractThe cold spray (CS) process is the latest solid-state deposition method that has gained significant awareness for the metallization of polymer matrix composites (PMCs) materials to modify their surface properties, including electrical or thermal conductivity and electromagnetic shielding. In comparison with other coating processes, CS allows for the production of metallic coatings without the necessity to reach the melting temperature of the sprayed particles and provides a way to deposit resistant materials with improved properties onto various components to minimize wear, erosion and corrosion. For the first time in the literature, this work has the innovative goal of applying the life cycle assessment methodology to the case study of the CS production process in order to ascertain whether CS could be framed in the realm of green technologies offering interesting opportunities to improve manufacturing sustainability. In particular, the environmental impact of CS associated with the metallization process of PMCs was considered in terms of energy consumption and CO2, NOx and SO2 emissions, which are used as indicators in the life cycle assessment. When compared to different coating processes, the results suggest that CS has a large potential to reduce the environmental effects connected with the products in terms of the amount of CO2 and hazardous emissions created throughout the process.
Exploring Miniaturized HVOF Systems for the Deposition of Ti-6Al-4V
Authors: Oberste-Berghaus J. , Aghasibeig M. , Burgess A. , Khamsepour P. , Moreau C. , Dolatabadi A. 
Published: January 2023

AbstractThe exceptional properties of Ti-6Al-4V of high strength, lightweight, corrosion resistance and machinability make it one of the most widely used alloys in in the aerospace industry. Significant efforts are underway to establish powder bed additive manufacturing technologies for Ti-6Al-4V. There are also increasing attempts to use thermal and cold spray to build near-net-shaped parts with buildup rates orders of magnitude higher than powder bed. Thermal spraying, such as HVOF, can oxidize and degrade the alloy due to the high processing temperature. Lowering the flame temperature through inert gas addition in full-size HVOF systems is a possible approach to retain solid-state deposition of the feedstock particles, thereby limiting oxidation and detrimental α-case formation, while providing sufficient heat input for particle softening and plastic deformation at impact. Novel miniaturized HVOF systems, with spray jets of only a few millimeters in width, may further offer the possibility to improve the spatial resolution of the buildup for near-net shape forming. The process parameter range for solid-state deposition of Ti-6A-4V using the liquid-fuelled TAFA Model 825 JPid and the novel hydrogen-fuelled Spraywerx ID-NOVA MK-6 with the addition of nitrogen is shown. Buildups at over 80% deposition efficiency generally yield as-sprayed porosities below 3% and hardness above 200 HV100gf. Attainable microstructures and oxygen content as a function of spray parameters are delineated. Recrystallization and beta-annealing of selected samples lower the residual porosity and can create equiaxed α and intergranular ß-phases. Ultimate tensile strengths of up to 1100 MPa were attained; however, the residual oxygen content of above 0.7% was found to limit β-phase formation, which contributes to a limited elongation to failure.
Role of Arterial Hypertension and Hypertension-Mediated Organ Damage in Cardiotoxicity of Anticancer Therapies
Authors: Tini Giacomo , Tocci Giuliano , Battistoni Allegra , Sarocchi Matteo , Pietrantoni Camilla , Russo Domitilla , Musumeci Beatrice , Savoia Carmine , Volpe Massimo , Spallarossa Paolo 
Published: January 2023

Abstract

Purpose of the Review
Arterial hypertension (AH) is the most common cardiovascular (CV) risk factor in the community and in oncologic patients. It also represents the most important CV condition predisposing to anticancer treatment-related cardiotoxicity. This risk is heightened in the presence of cardiac AH-mediated organ damage (HMOD). Influence of AH and HMOD on the development of cardiotoxicity will be reviewed, with a focus on specific scenarios and implications for management of oncologic patients.

Recent Findings
Not adequately controlled AH before or during anticancer treatments and/or development of AH during or after completion of such therapies have detrimental effects on the clinical course of oncologic patients, particularly if HMOD is present.

Summary
As overlooking CV health can jeopardize the success of anticancer treatments, the goal for clinicians caring for the oncologic patient should include the treatment of AH and HMOD.
Extracellular Vesicles from NMN Preconditioned Mesenchymal Stem Cells Ameliorated Myocardial Infarction via miR-210-3p Promoted Angiogenesis
Authors: Pu Yanan , Li Chunyu , Qi Xin , Xu Rui , Dong Liyang , Jiang Yi , Gong Qingyun , Wang Di , Cheng Rong , Zhang Cheng , Chen Yan 
Published: January 2023

Abstract
Mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs) possess cardioprotection in acute myocardial infarction. Nevertheless, the therapeutic intervention potential and the molecular mechanism of EVs from NMN (Nicotinamide mononucleotide) preconditioned hUCMSCs (N-EVs) in acute myocardial infarction remains unknown. In the present study, EVs from hUCMSCs (M-EVs) and N-EVs were identified by electron microscopy, immunoblotting and nanoparticle tracking analysis. Compared with M-EVs, N-EVs significantly increased the proliferation, migration, and angiogenesis of HUVECs. Meanwhile, N-EVs markedly reduced apoptosis and cardiac fibrosis and promoted angiogenesis in the peri-infarct region in the MI rats. A high-throughput miRNA sequencing and qPCR methods analysis revealed that miR-210-3p was abundant in N-EVs and the expression of miR-210-3p was obviously upregulated in HUVECs after N-EVs treated. Overexpression of miR-210-3p in HUVECs significantly enhanced the tube formation, migration and proliferative capacities of HUVECs. However, downregulation of miR-210-3p in HUVECs markedly decreased the tube formation, migration and proliferative capacities of HUVECs. Furthermore, bioinformatics analysis and luciferase assays revealed that EphrinA3 (EFNA3) was a direct target of miR-210-3p. Knockdown of miR-210-3p in N-EVs significantly impaired its ability to protect the heart after myocardial infarction. Altogether, these results indicated that N-EVs promoted the infarct healing through improvement of angiogenesis by miR-210-3p via targeting the EFNA3.

Graphical Abstract
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