bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of 25(OH)D3 and circRNAs in early diagnosis of gestational diabetes mellitus
Authors: Zou Jinghui , Liu Yan , Shen Jun , Xue Aijiao , Yan Lulu , Zhang Yisheng 
Published: January 2023

AbstractObjectiveTo explore the relationship between 25(OH)D3 and circular RNAs (circRNAs) in the early diagnosis of gestational diabetes mellitus (GDM) and to screen for biological markers for early prediction of GDM.MethodsA cohort study was conducted using samples and data collected from pregnant women registered at the Li Huili hospital in China between April 2018 and January 2020. Four circRNAs (hsa_circ_0003218, hsa_circ_0002968, hsa_circ_0007430, and hsa_circ_0006260) were selected as potential biomarkers, and quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) was used to measure their concentration in the serum and to analyze their correlation with 25(OH)D3. The Pearson correlation test was used to assess the correlation between the 25(OH)D3, circRNAs, and various clinical variables. The area under the receiver operating characteristic (ROC) curve was used to assess the diagnostic value of circRNAs and 25(OH)D3 in the early stage of pregnancy.ResultsWeight, body mass index (BMI), triglycerides, total cholesterol, high‐density lipoprotein cholesterol (HDL‐C), and 25(OH)D3 were found to be risk factors for GDM. The level of 25(OH)D3 correlated significantly with HDL‐C with a correlation coefficient of 0.298 (p < 0.05). The expression of hsa_circ_0003218 was significantly downregulated in the GDM group (p < 0.05). Hsa_circ_0002968, hsa_circ_0007430, and hsa_circ_0006260 did not show any differential expression between the two groups (p > 0.05). Furthermore, hsa_circ_0003218 level correlated significantly with 25(OH)D3 and the correlation coefficient was 0.357 (p < 0.05). The AUC of hsa_circ_0003218 combined with 25(OH)D3 was 0.789 ([0.700–0.877], p < 0.001), with sensitivity and specificity of 63.04% and 80.65%, respectively.ConclusionsHsa_circ_0003218 and 25(OH)D3 may jointly participate in the metabolic process of GDM. Thus, the combination of 25(OH)D3 and hsa_circ_0003218 represents a potential biomarker for the prediction of GDM in the early stages of pregnancy.
Gastroesophageal reflux disease incidence among male patients with irritable bowel syndrome: A single‐center cross‐sectional study in southern Iran
Authors: Gholamnezhad Fereshteh , Qeisari Ahmad , Shahriarirad Reza 
Published: January 2023

AbstractBackground and AimGastrointestinal reflux disease (GERD) and irritable bowel syndrome (IBS) are among the most common gastrointestinal disorders in which the overlap of these diseases and their syndromes has been frequently reported. In this study, we aimed to evaluate GERD incidence among IBS patients and the related risk factors.MethodsMale patients aged 18–60 years with an impression of IBS and referred to the gastrointestinal clinic from March 2019 to 2020 in Shiraz, Iran, were included in this study.ResultsAmong the 163 enrolled patients with an average age of 31.53 ± 9.38 years, 64 (39.3%) were diagnosed with GERD. Based on statistical analysis, there was a significant association between GERD and the IBS patients' age (P = 0.006), smoking (P = 0.011), and alcohol consumption (P = 0.043). Also, GERD among IBS patients was significantly associated with the type of IBS (P < 0.001), with IBS‐D having the lowest incidence (19.4%) and IBS‐M the highest incidence of GERD (66.7%). Based on multivariate analysis, smoking had a reverse and significant correlation with lower incidence of GERD (OR = −1.364; P = 0.002).ConclusionOur results demonstrate that among male IBS patients, younger age, smoking, and alcohol consumption were among the risk factors for GERD. These findings may provide further insight into the best approach to treating these diseases.
An immunoinformatics and structural vaccinology study to design a multi‐epitope vaccine against Staphylococcus aureus infection
Authors: Chatterjee Rahul , Mahapatra Soumya Ranjan , Dey Jyotirmayee , Raj Takur Kiran , Raina Vishakha , Misra Namrata , Suar Mrutyunjay 
Published: January 2023

AbstractStaphylococcus aureus has been widely reported to be majorly responsible for causing nosocomial infections worldwide. Due to an increase in antibiotic‐resistant strains, the development of an effective vaccine against the bacteria is the most viable alternative. Therefore, in the current work, an effort has been undertaken to develop a novel peptide‐based vaccine construct against S aureus that can potentially evoke the B and T cell immune responses. The fibronectin‐binding proteins are an attractive target as they play a prominent role in bacterial adherence and host cell invasion and are also well conserved among rapidly mutating pathogens. Therefore, highly immunogenic linear B lymphocytes (LBL), cytotoxic T lymphocytes (CTL), and helper T lymphocytes (HTL) epitopes were identified from the antigenic fibronectin‐binding proteins A and B (FnBPA and FnBPB) of S aureus using immunoinformatics approaches. The selected peptides were confirmed to be non‐allergenic, non‐toxic, and with a high binding affinity to the majority of human leukocyte antigens (HLA) alleles. Consequently, the multi‐peptide vaccine construct was developed by fusing the screened epitopes (three LBL, five CTL, and two HTL) together with the suitable adjuvant and linkers. In addition, the tertiary conformation of the peptide construct was modeled and later docked to the Toll‐like receptor 2. Subsequently, a molecular dynamics simulation of 100 ns was employed to corroborate the stability of the designed vaccine‐receptor complex. Besides exhibiting high immunogenicity and conformational stability, the developed vaccine was observed to possess wide population coverage of 99.51% worldwide. Additional in vivo and in vitro validation studies would certainly corroborate the designed vaccine construct to have improved prophylactic efficacy against S aureus.
Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers
Authors: Sabeena Sasidharanpillai 
Published: January 2023

AbstractCervical cancer is a significant public health problem in developing countries, as most cases present at an advanced stage. This review aimed to analyze the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancers. Published studies on specific microRNA signatures in body fluids and cervical cancer tissues are highly heterogeneous, and there are no validated assays. The precision of the various immune‐associated long noncoding (lncRNA) signatures should be assessed in clinical samples. Even though lncRNAs are tissue and cancer‐specific, safe and appropriate methods for delivery to tumor tissues, toxicities and side effects are to be explored. Few studies have evaluated deregulated lncRNA expression levels with clinicopathological factors in a limited number of clinical samples. Prospective studies assessing the diagnostic and prognostic roles of circulating lncRNAs and P‐Element‐induced wimpy testis interacting PIWI RNAs (Piwil RNAs) in cervical cancer cases are essential. For the clinical application of lnc‐RNA‐based biomarkers, comprehensive research is needed as the impact of noncoding transcripts on molecular pathways is complex. The standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are needed.
Multilevel outcomes of creativity in organizations: An integrative review and agenda for future research
Authors: Lua Egan , Liu Dong , Shalley Christina E. 
Published: January 2023

SummaryEmployee creativity is critical for an organization's innovativeness and survival in today's competitive business environment. As such, scholars have devoted significant attention to the predictors of employee creativity, seeking to understand how to best increase employees' creative output. However, employee creativity may not always translate into organizational innovation and performance. In fact, employee creativity may result in various outcomes for creative individuals, their coworkers, teams, and organizations. While there have been several integrative reviews on the antecedents of creativity, an in‐depth review of the outcomes of creativity is still needed to gain a holistic understanding of the benefits and costs of employee creativity and identify fruitful areas for future research. Thus, we aim to provide a comprehensive multilevel examination of the theories, methods, and creativity‐related constructs used to examine the outcomes of creativity. We also provide several theoretical and empirical opportunities for future research. This review may provide managers with knowledge of the pros and cons of employee creativity, enabling them to make informed decisions on how to better manage employee creativity.
Consumer perception of salt‐reduced bread with the addition of brown seaweed evaluated under blinded and informed conditions
Authors: Gorman Mackenzie , Moss Rachael , Barker Sophie , Falkeisen Anika , Knowles Sophie , McSweeney Matthew B 
Published: January 2023

AbstractBACKGROUNDMany consumers have a high salt intake and bread is a primary source because of its high rate of consumption. The inclusion of seaweeds has been proposed as an ingredient that could help reduce the salt content of food products. As such, the present study aimed to evaluate whether the amount of salt in bread could be reduced and the change in sensory properties be mitigated by the inclusion of brown seaweed. There were two different sensory trials conducted. In the first trial, participants (n = 102) evaluated bread made with brown seaweed (4% substitution for flour) with reduced amounts of salt (10%, 20%, 30%, 40% and 50%). The second trial asked participants (n = 98) to evaluate the control bread and the 20% salt‐reduced bread in blinded and informed conditions. In both sensory trials, the breads samples were assessed using hedonic scales, just‐about‐right scales, and check‐all‐that‐apply.RESULTSThe results showed that the 10% and 20% salt‐reduced breads were acceptable and associated with being soft, chewy and having no aftertaste. The other breads were associated with a dense, dry and strong aftertaste, along with not being salty enough for the consumers. When the breads were evaluated in informed conditions, the salt reduction label had a negative impact on the consumers' liking.CONCLUSIONThe research emphasizes that salt‐reduced labels influence consumers' sensory perception. © 2023 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Cancer risk‐reducing surgery: Brazilian society of surgical oncology guideline part 1 (gynecology and breast)
Authors: Carneiro Vandré Cabral Gomes , Gifoni Ana Carolina Leite Vieira Costa , Mauro Rossi Benedito , Andrade Carlos Eduardo Mattos da Cunha , Lima Fernanda Teresa de , Galvão Henrique de Campos Reis , Casali da Rocha Jose Claudio , Silva Barreto Leonardo Silveira da , Ashton‐Prolla Patrícia , Guindalini Rodrigo Santa Cruz , Farias Terence Pires de , Andrade Wesley Pereira , Fernandes Paulo Henrique de Sousa , Ribeiro Reitan , Lopes Andre , Tsunoda Audrey Tieko , Azevedo Bruno Roberto Braga , Marins Carlos Augusto Martinez , Oliveira Uchôa Diego Nunes de Albuquerque , Dos Santos Evandro Airton Sordi , Fernández Coimbra Felipe José , Dias Filho Francisco Alcides , Lopes Francisco Carlos de Oliveira , Fernandes Francisco Guilherme , Ritt Guilherme Fonteles , Laporte Gustavo Andreazza , Guimaraes Gustavo Cardoso , Feitosa e Castro Neto Heládio , dos Santos Jocela Cristina , de Carvalho Vilela Jordana Botelho , Meinhardt Junior Jorge Guardiola , Cunha Juliano Rodrigues da , Medeiros Milhomem Leonardo , da Silva Luciana Mata , Maciel Luiza de Freitas , Ramalho Nathalia Moreira , Leite Nunes Rafael , Guido de Araújo Rodrigo , de Assunção Ehrhardt Rogério , Delgado Bocanegra Ronald Enrique , Silva Junior Tyrone Cesar , Oliveira Viviane Rezende de , Silva Surimã Walyson , de Melo Melquiades Miriam , Ribeiro Heber Salvador de Castro , Oliveira Alexandre Ferreira 
Published: January 2023

AbstractBackgroundRisk‐reducing operations are an important part of the management of hereditary predisposition to cancer. In selected cases, they can considerably reduce the morbidity and mortality associated with cancer in this population.ObjectivesThe Brazilian Society of Surgical Oncology (BSSO) developed this guideline to establish national benchmarks for cancer risk‐reducing operations.MethodsThe guideline was prepared from May to December 2021 by a multidisciplinary team of experts to discuss the surgical management of cancer predisposition syndromes. Fourteen questions were defined and assigned to expert groups that reviewed the literature and drafted preliminary recommendations. Following a review by the coordinators and a second review by all participants, the groups made final adjustments, classified the level of evidence, and voted on the recommendations.ResultsFor all questions including risk‐reduction bilateral salpingo‐oophorectomy, hysterectomy, and mastectomy, major agreement was achieved by the participants, always using accessible alternatives.ConclusionThis and its accompanying article represent the first guideline in cancer risk reduction surgery developed by the BSSO, and it should serve as an important reference for the management of families with cancer predisposition.
Unbalanced expression of sICOS and sPD‐1 correlates with tumor progression in gastric cancer
Authors: Lima Cecília A. C. , da Silva Luciana M. , dos Santos Rogério L. , Silva Jerônimo P. A. , Forones Nora M. , Martins Mário R. , Torres Leuridan C. 
Published: January 2023

AbstractBackground and ObjectivesT cells are central in antitumor immunity in gastric cancer (GC). The inducible costimulatory molecule (ICOS) is a T cell receptor that primarily transmits positive signals for T cell activation and is associated with poor prognosis in GC. In contrast, the costimulatory molecule programmed death 1 (PD‐1) is an inhibitory receptor related to tumor immune escape. This study aimed to analyze soluble sites and sPD‐1 levels in GC.MethodsThis study enrolled 83 GC patients and 20 healthy controls.ResultsThe median survival time was 23.22 months in the GC patients. Low levels of sPD‐1 and sICOS in GC patients compared to the control group (p = 0.003; p < 0.0001, respectively). High sPD‐1 levels in stage IV patients compared to I/II and III stages groups (p = 0.008 and p = 0.0004, respectively). GC patients with stages I and II had higher levels of sICOS compared to III and IV stages (p = 0.0005 and p = 0.02, respectively). There were no significant differences in sPD‐1 and sICOS levels between Lauren subtypes.ConclusionThese results suggest a predominance of inhibitory costimulatory signals in advanced stages of GC, facilitating tumor immune escape, as the opposite occurs in early stages, resulting in an effective antitumor T‐cell‐mediated immune response.
Brazilian Society of Surgical Oncology consensus on fertility‐sparing surgery for cervical cancer
Authors: Baiocchi Glauco , Tsunoda Audrey Tieko , Guitmann Gustavo , Vieira Marcelo Andrade , Zanvettor Paulo Henrique , Silvestre Janiceli Blanca Carlotto Hablich , Santos Marcelo Henrique , Sacramento Raquel de Maria Maués , de Araujo Eliel Oliveira , Lopes Roberto Heleno , Falcao Deraldo , Lopes Andre , Schmidt Ronaldo , Lyra Jorge Soares , Almeida Herbert Ives Barretto , Casteleins William Augusto , Cintra Georgia Fontes , Zanini Lucas Adalberto Geraldi , Reis Rosilene Jara , Coelho Eid Gonçalves , Fin Fábio Roberto , Rezende Viviane , Pançan Thais Dvulatk Marques , Vieira Sabas Carlos , Silva Jeancarllo Sousa , de Andrade Manoel Rodrigues , Carneiro Vandre Cabral Gomes , Foiato Tariane Friedrich , Ritt Guilherme Fonteles , Ianaze Gustavo Castro , Moretti‐Marques Renato , Andrade Carlos Eduardo Mattos Cunha , Maciel Luiza Freitas , Lira Daniel Lourenço , Medeiros Gustavo Mendes , Leite Amanda Lira Santos , Cucolicchio Guilherme Oliveira , Tayeh Muhamed Read Ali , Cruz Ricardo Pedrini , Guth Gustavo Ziggiatti , Leal Renato Mazon Lina Verde , Magno Valentino Antonio , Lopes Francisco Carlos Oliveira , Laporte Gustavo Andreazza , Pupo‐Nogueira Alexandre , Barros Aldo Vieira , da Cunha Juliano Rodrigues , Pessini Suzana Arenhart , Braganca Joana Froes , Figueiredo Higino Felipe , Loureiro Carlos Manoel Bulcão , Bocanegra Ronald Enrique Delgado , Affonso Renato José , Fernandes Paulo Henrique de Souza , Ribeiro Heber Salvador Castro , Batista Thales Paulo , Oliveira Alexandre Ferreira , Ribeiro Reitan 
Published: January 2023

AbstractObjectiveSeveral controversies remain on conservative management of cervical cancer. Our aim was to develop a consensus recommendation on important and novel topics of fertility‐sparing treatment of cervical cancer.MethodsThe consensus was sponsored by the Brazilian Society of Surgical Oncology (BSSO) from March 2020 to September 2020 and included a multidisciplinary team of 55 specialists. A total of 21 questions were addressed and they were assigned to specialists' groups that reviewed the literature and drafted preliminary recommendations. Further, the coordinators evaluated the recommendations that were classified by the level of evidence, and finally, they were voted by all participants.ResultsThe questions included controversial topics on tumor assessment, surgical treatment, and surveillance in conservative management of cervical cancer. The two topics with lower agreement rates were the role of minimally invasive approach in radical trachelectomy and parametrial preservation. Additionally, only three recommendations had <90% of agreement (fertility preservation in Stage Ib2, anti‐stenosis device, and uterine transposition).ConclusionsAs very few clinical trials have been developed in surgery for cervical cancer, most recommendations were supported by low levels of evidence. We addressed important and novel topics in conservative management of cervical cancer and our study may contribute to literature.
PD‐L1 expression in gastric and gastroesophageal junction cancer patients treated with perioperative chemotherapy
Authors: Ribeiro Héber S. C. , Menezes Jacqueline N. , da Costa Wilson L. , F. de Jesus Victor Hugo , Diniz Alessandro L. , Godoy André L. , de Farias Igor Correia , Torres Silvio M. , Neotti Tatiane , Mello Celso A. L. , Begnami Maria Dirlei F. S. , Dias‐Neto Emmanuel , Riechelmann Rachel P. , Fernandez Coimbra Felipe José 
Published: January 2023

AbstractBackground and ObjectivesThe incidence, predictive, and prognostic impact of programmed cell death (PD‐L1) expression in gastric (GC) and gastroesophageal junction tumors (GEJC) treated with perioperative chemotherapy is poorly understood. We aimed to assess PD‐L1 expression by immunohistochemistry (IHC) in both pre and posttreatment specimens evaluating its impact on pathological response and survival outcomes.MethodsRetrospective cohort of patients with GC and GEJ tumors treated in a single western cancer center between 2007 and 2017. PD‐L1 expression was assessed by IHC before and after neoadjuvant chemotherapy, in surgical samples, and reported as combined positive score (CPS). CPS > 1% was tested for its association with pathological response and overall survival (OS).ResultsWe were able to assess PD‐L1 expression in at least one tissue sample from 155 subjects. PD‐L1 positivity rate was 20%. In 74 paired samples, a 21% discordance between PD‐L1 expression in biopsy sample and surgical specimen was observed. With a median follow‐up period of 60.3 months, 5‐years disease‐free survival was 60.5% with a median OS not reached. PD‐L1 expression was neither associated with pathological response or survival outcomes.ConclusionsPD‐L1 expression in the setting of locally advanced GC tumors was relatively low and can vary considering the tissue sample analyzed. This expression had no association with survival or pathological response in this population.
Date palm cultivation: A review of soil and environmental conditions and future challenges
Authors: Alotaibi Khaled D. , Alharbi Hattan A. , Yaish Mahmoud W. , Ahmed Ibrahim , Alharbi Sulaiman Almwarai , Alotaibi Fahad , Kuzyakov Yakov 
Published: January 2023

AbstractDate palm (Phoenix dactyliferaL.) fruit is one of the ancient crops that have been cultivated for thousands of years in the arid regions of the Middle East and North Africa. Its nutritional and economic importance has extended the cultivation to other countries with suitable environmental conditions. Despite the large expansion in date palm cultivation and the associated improvement in its yield and quality over the last few decades, challenges remain in its cultivation and sustainability. Here, we review: (1) the current status of date palm cultivation, (2) the key environmental and soil‐related factors influencing its cultivation and productivity, and (3) the challenges under global change in addition to assessing the future potentials for improvements and sustainability. The global production of date palm has increased by 18% during the last ten years, reaching 8.53 million tons, on a total area of 1.11 million ha. Water scarcity and salinity stresses are the major constraints affecting date palm productivity, which is a serious issue in arid regions, where water resources are becoming depleted and soil is becoming increasingly salinized due to limited rainfall, high evapotranspiration, and incorrect irrigation. Although date palm can tolerate salinity up to 12 dS m−1, accumulation of salts in soil strongly reduces the yield. The main cultivation areas are dominated by soils of sandy texture with high pH and a low capacity for water and nutrient retention. Organic fertilizers increase water and nutrient retention. There is a lack of long‐term studies (e.g., ≥10 years) designed to monitor date palm cultivar responses to abiotic stresses as well as to nutrition and management practices. Future challenges facing date palm cultivation mainly include water shortages, extremely high temperatures, salinity, and soil degradation, as well as diseases and pests. The implementation of efficient management practices, including modern irrigation systems, selecting cultivars most suitable for the local environmental conditions, and increasing soil water and nutrient retention, help to sustain date palm cultivation and productivity.
Experimental study of corrosion behavior on 7005 aluminum alloy under acidic 3.5 wt% NaCl environment
Authors: Wang Guan , Li Xinhui , Kou Linyuan , Ma Yongxiang , Liu Hongping , Zhu Xuejun , Shang Xin 
Published: January 2023

AbstractThe corrosion failure behavior of 7005 aluminum alloy is a critical issue in the durability studies of vessels operating. In this study, the corrosion behavior of aluminum alloy 7005‐T4 in 3.5 wt% NaCl solution with pH 2, pH 4, and pH 6 was investigated by surface observation, electrochemical, and mechanical testing. The experiment results that the corrosion susceptibility is more at a solution of pH 2 compared with that at pH 4 and pH 6. The maximum depth and width of corrosion pits increase linearly with aggravation of corrosion. In addition, the probability distribution of the corrosion pit depth in each corrosion environment, which generally follows a Lognormal distribution, is statistically analyzed. The tendency of stress−strain curves at the elastic−plastic transition stage indicated that corrosion has an effect on mechanical performance, and revealed that corrosion promotes the advance of the plastic deformation stage. Fractography indicated the presence of a quasi‐cleavage zone beneath the corrosion layer. The results provide theoretical guidance for safe service and design guidelines for 7005 aluminum alloy.