bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphometric analysis of the foramen magnum in sex estimation: An additional 3DCT study from Nepal on a larger sample
Authors: Atreya Alok , Shrestha Rijen , Bhandari Kiran , Malla Saurav K. , Acharya Sumnima , Menezes Ritesh G. 
Published: December 2022

AbstractBackgroundEstimation of sex of the skeletal remains plays a vital part in the identification of an individual. This study is focused on the morphometric measurements of the foramen magnum region and examining the accuracy of sexual dimorphism in the Nepalese population.MethodsMeasurements were obtained from 3D computed tomography (CT) scan of 261 Nepalese adult cranial bases with known age and sex. Length and breadth of the foramen magnum, length and breadth of right and left occipital condyles and maximum and minimum intercondylar distance were measured on the base of the skull CT images.ResultsThe mean values for all parameters were higher in males than females except for the maximum intercondylar distance. Sex prediction done with discriminant function analysis could classify the skull with an overall accuracy of 70.5%–71%.ConclusionsIt can be concluded from the results that the morphometric study of the foramen magnum is less reliable for sex estimation in the Nepalese population.
Estimating water fluxes in the critical zone using water stable isotope approaches in the Groundnut and Ferlo basins of Senegal
Authors: Diongue Djim M. L. , Stumpp Christine , Roupsard Olivier , Orange Didier , Do Frederic C. , Faye Serigne 
Published: December 2022

AbstractSustainable water management in semi‐arid agriculture practices requires quantitative knowledge of water fluxes within the soil‐vegetation‐atmosphere system. Therefore, we used stable‐isotope approaches to evaluate evaporation (Ea), transpiration (Ta), and groundwater recharge (R) at sites in Senegal's Groundnut basin and Ferlo Valley pasture region during the pre‐monsoon, monsoon, and post‐monsoon seasons of 2021. The approaches were based upon (i) the isothermal evaporation model (for quantifying Ea); (ii) water and isotope mass balances (to partition Ea and Ta for groundnut and pasture); and (iii) the piston displacement method (for estimating R). Ea losses derived from the isothermal evaporation model corresponded primarily to Stage II evaporation, and ranged from 0.02 to 0.09 mm d−1 in the Groundnut basin, versus 0.02–0.11 mm d−1 in Ferlo. At the groundnut site, Ea rates ranged from 0.01 to 0.69 mm d−1; Ta was in the range 0.55–2.29 mm d−1; and the Ta/ETa ratio was 74%–90%. At the pasture site, the ranges were 0.02–0.39 mm d−1 for Ea; 0.9–1.69 mm d−1 for Ta; and 62–90% for Ta/ETa. The ETa value derived for the groundnut site via the isotope approach was similar to those from eddy covariance measurements, and also to the results from the previous validated HYDRUS‐1D model. However, the HYDRUS‐1D model gave a lower Ta/ETa ratio (23.2%). The computed groundwater recharge for the groundnut site amounted to less than 2% of the local annual precipitation. Recommendations are made regarding protocols for preventing changes to isotopic compositions of water in samples that are collected in remote arid regions, but must be analysed days later. The article ends with suggestions for studies to follow up on evidence that local aquifers are being recharged via preferential pathways.
Inventory information arrival and the crude oil futures market
Authors: Chebbi Tarek , Hmedat Waleed 
Published: December 2022

AbstractThe objective of this paper is to provide a deeper insight into the impact of weekly inventory announcements and especially their associated surprises on crude oil returns and volatility during the period from 27 March 2012 to 2 October 2018. The results can be summarized as follows. First, we find that all inventory surprises exert an inverse impact on the oil price returns. Such impact appears more pronounced during the collapse and post‐collapse periods, than during the pre‐collapse period. Second, we show that the reducing volatility effects of inventory shocks that we establish for the whole period are entirely attributed to those observed in the pre‐collapse period. Third, the different effects obtained for positive and negative shocks support evidence that our split of inventory news by nature matters. Fourth, compared to macroeconomic and unconventional monetary news, the inventory statements appear as the most pertinent news during the event window. Fifth, we find evidence also that the effect of the uncertainty about economic stance, when it is significant, changes the way the oil prices and volatility react to inventory surprises, and hence weakens the effectiveness of the inventory policy. Lastly, we make an original use of the information content of the implied volatility to assess the persistence of the link between the conditional variance and the inventory news. The central finding is that the implied volatility enters with a significant effect on the conditional variance for WTI oil returns and namely with a reduced volatility persistence. Also, a significant effect from inventory surprises namely when we split the announcements into negative and positive news is detected even the implied volatility is introduced exogenously in the GARCH‐type variance specification highlighting the predominance of our main variable.
Postpartum severe acute maternal morbidity according to gestational age at delivery in twin pregnancies: A prospective cohort study
Authors: Loussert Lola , Deneux‐Tharaux Catherine , Seco Aurélien , Goffinet François , Korb Diane , Schmitz Thomas ,   for the JUmeaux MODe d'Accouchement (JUMODA) study group and the Groupe de Recherche en Obstétrique et Gynécologie (GROG)
Published: December 2022

AbstractObjectiveTo assess the association between gestational age at delivery and postpartum severe acute maternal morbidity (SAMM) in twin pregnancies.MethodsSecondary analysis of the JUMODA cohort, a national, prospective, population‐based study of twin pregnancies in France. We excluded women with delivery before 32 weeks of pregnancy, with a fetal death or medical termination, with antepartum SAMM, or with antepartum conditions responsible for postpartum SAMM. The primary outcome was a composite of postpartum SAMM. We assessed the association between gestational age at delivery and SAMM by using multivariable multilevel modified Poisson regression modeling.ResultsAmong the 7713 women included, 410 (5.3%) developed postpartum SAMM. Compared with the reference category of 37 weeks of pregnancy, the risk of postpartum SAMM was significantly lower for all categories of earlier gestational age at delivery (from an adjusted relative risk [RR] of 0.34, 95% confidence interval [CI] 0.17–0.68 at 32 weeks to an adjusted RR of 0.71, 95% CI 0.54–0.94 at 36 weeks), and did not differ for later gestational ages.ConclusionIn twin pregnancies, compared with delivery at 37 weeks of pregnancy, delivery at earlier gestational ages was associated with a lower risk of postpartum SAMM. Continuing pregnancy beyond 37 weeks of pregnancy is not associated with an increased risk of postpartum SAMM.
Fetal malpresentation following mechanical labor induction
Authors: Bart Yossi , Meyer Raanan , Yoeli Rakefet , Mazaki‐Tovi Shali , Tsur Abraham , Levin Gabriel , Sibai Baha M. , Chauhan Suneet P. , Bartal Michal Fishel 
Published: December 2022

AbstractObjectiveTo evaluate whether the risk of fetal malpresentation following mechanical labor induction could be accurately predicted.MethodsA retrospective study, including all individuals who underwent labor induction at a single tertiary medical center between March 2011 and May 2021. Cohorts of pharmacological (n = 16 480) and mechanical labor induction (n = 6864) were compared, determining malpresentation rate following induction. Individuals with and without fetal malpresentation following balloon placement were compared.ResultsMalpresentation following balloon placement occurred in 62 patients (0.9%). Those patients with malpresentation following balloon placement were older, had higher body mass index during labor, higher parity, polyhydramnios, higher fetal station at the start of labor induction, and delivered at an earlier gestational age compared with control patients. The combined presence of at least three of these risk factors was associated with a malpresentation rate of 8% (7/88) and yielded a positive likelihood ratio of 9.48 (95% confidence interval [CI] 4.57–19.7). A prediction model using these variables was not sufficiently accurate to predict the risk of malpresentation following balloon labor induction; a calculated area under the generated receiver operating characteristic curve was 0.78 (95% CI 0.72–0.84).ConclusionSeveral risk factors were identified for malpresentation following mechanical labor induction, although these were of low predictive value.
Single‐visit long‐acting reversible contraception provision and pregnancy rates within 3 months
Authors: Manhiça Suzana I. , Bahamondes Luis , Laporte Montas , Anjos Fabiana , Viscola Marco , Garcia Elaine , Paiva Lucia C. 
Published: December 2022

AbstractObjectivesTo assess the occurrence of pregnancy in a cohort of women who received a copper intrauterine device (IUD), hormonal IUDs or an etonogestrel (ENG) contraceptive implant at a single‐visit practice.MethodsProspective study conducted at the University of Campinas, Campinas, São Paulo, Brazil. We obtained data from four ongoing studies including both the date of the device placement, the first day of the last menstrual period, and the occurrence of pregnancy up to 3 months after device placement.ResultsWe included 2479 device placements (413 TCu380A IUDs, 1476 hormonal IUD and 590 ENG implants). Almost half of the device placements (1113/2479; 44.9%) were performed within the first 5 days of the menstrual cycle. We observed three pregnancies: one in an ENG implant user who received the implant within days 1–5 of the menstrual cycle; one in a woman who received a hormonal IUD during days 6–10 of the menstrual cycle; and one in a copper IUD user with placement during days 21–25 of menstrual cycle.ConclusionsSingle‐visit long‐acting reversible contraception placements are a good strategy with overall very low pregnancy rates. This strategy has a potential to reduce unintended pregnancies and to reduce costs and barriers to both women and the healthcare system.
A survey of patient‐centered practices in perinatal quality collaboratives
Authors: McGowan Makazhia , D'Amico Mara , Kang Minji , Ling Vivian , Moniz Michelle H. , Morgan Daniel M. , Peahl Alex F. 
Published: December 2022

SynopsisPerinatal quality collaboratives must incorporate patient and community member preferences in the design and evaluation of quality improvement initiatives to achieve truly patient‐centered maternity care.
Rapid deterioration of renal function following coronavirus disease 2019 in a renal transplant recipient
Authors: Machiya Seigo , Nakazawa Shigeaki , Fukae Shota , Tanaka Ryo , Taniguchi Ayumu , Yamanaka Kazuaki , Takahara Shiro , Namba‐Hamano Tomoko , Imamura Ryoichi , Nonomura Norio 
Published: December 2022

IntroductionThe coronavirus disease 2019 pandemic emerged in December 2019. Renal transplant recipients receiving chronic immunosuppression are considered to be at a high risk of infection. Aside from upper respiratory tract symptoms, coronavirus disease 2019 has also been reported to cause acute kidney injury in 20–50% of infected cases.Case presentationA 62‐year‐old male renal transplant recipient presented with high fever, diarrhea, and cough, concurrent with rapid deterioration of graft function. The patient tested positive for coronavirus disease 2019. The pathological findings of the graft biopsy revealed diffuse flattening of tubular epithelial cells and extensive loss of the brush border in proximal tubular cells. Mycophenolate mofetil was discontinued and sotrovimab, remdesivir, intravenous immunoglobulin, and intravenous methylprednisolone were administered, resulting in gradual improvements in clinical symptoms and renal function.ConclusionWe describe a case of a coronavirus disease 2019‐infected kidney transplant recipient who developed severe acute kidney injury caused by severe acute tubular necrosis.
The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes
Authors: Ertik Onur , Sener Goksel , Yanardag Refiye 
Published: December 2022

AbstractIn this present study, the duration of melatonin (Mel) administered to diabetic rats was prolonged so as to examine its effects on the biochemical liver parameters of diabetic rats. In the experiment, Male Sprague Dawley rats were divided randomly into five groups; the control, diabetic + Mel, diabetic, diabetic + insulin, and diabetic + Mel + insulin. Diabetes mellitus was induced by administration of a single dose of streptozotocin (60 mg/kg) intraperitoneally and rats were given vehicle as a solvent for Mel every day for 12 weeks. In the diabetic + Mel group, diabetic rats were administered Mel (10 mg/kg/day) for 12 weeks to treat diabetes. The diabetic + insulin group were diabetic rats given insulin (6 U/kg) subcutaneously for 12 weeks. The diabetic + Mel + insulin rats received insulin and Mel at the same dose and time. At the end of the experiment, the animals were decapitated and liver tissues were taken. The protective effect of Mel on liver tissue of diabetic rats was investigated, total antioxidant status, total oxidant status, reactive oxygen species, oxidative stress index, adenosine deaminase, xanthine oxidase, paraoxonase 1, sodium/potassium ATPase, myeloperoxidase, γ‐glutamyl transferase, sorbitol dehydrogenase, tumor necrosis factor‐alpha, homocysteine, nitric oxide, glucose‐6‐phosphate dehydrogenase, and glycoprotein levels were determined in liver tissues. Treatment with Mel and/or insulin has been found to have a protective effect on biochemical parameters. The results showed that administration of Mel to diabetic rats prevented the distortion of the studied biochemical parameters of liver tissues.
Unraveling solvent‐dependent hydrogen bonding interaction and excited‐state intramolecular proton transfer behavior for 2‐(benzo[d]thiazol‐2‐yl)‐4‐(9H‐carbazol‐9‐yl)phenol: A theoretical study
Authors: Dong Hao , Jiang Wenkun , Lv Gang , Han Yinghui 
Published: December 2022

AbstractOrganic chemosensors with excited‐state intramolecular proton transfer (ESIPT) behavior have attracted much attention because it has great potential in a wide range of applications. Considering the paramount behavior of excited‐state relaxation, in this work, we mainly focus on deciphering photo‐induced hydrogen bonding effects and ESIPT mechanism for the novel 2‐(benzo[d]thiazol‐2‐yl)‐4‐(9H‐carbazol‐9‐yl)phenol (mCzOH) dye. Considering the effects of different solvents on excited‐state dynamics of mCzOH flurophore, we adopt four solvents with different polarities. Analyses of fundamental structural changes, infrared (IR) vibrational spectra, and core valence partition index between S0 and S1 state, we confirm hydrogen bond OH···N of mCzOH should be enhanced via photoexcitation. Especially, the increase of solvent polarity could promote hydrogen bonding strengthening degree. Intramolecular charge transfer (ICT) resulting from photoexcitation qualitatively facilitates the ESIPT occurrence to a large extent. For further checking and probing into ESIPT mechanism, via constructing potential energy curves (PECs) in four solvents, we clarify the ESIPT behavior for mCzOH. Most worthy of mention is that polar solvent plays critical roles in lowering potential barrier of ESIPT reaction and in facilitating ESIPT process. We not only clarify the detailed excited‐state process, but also present the solvent‐polarity‐dependent ESIPT mechanism for mCzOH fluorophore.
Targeting the DP2 receptor alleviates muscle atrophy and diet‐induced obesity in mice through oxidative myofiber transition
Authors: Ning Huying , Ren Huiwen , Zhao Yan , Yin HaiFang , Gan Zhenji , Shen Yujun , Yu Ying 
Published: December 2022

AbstractBackgroundMammalian skeletal muscles consist of two main fibre types: slow‐twitch (type I, oxidative) and fast‐twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre composition switch is closely associated with chronic diseases such as muscle atrophy, obesity, type II diabetes and athletic performance. Prostaglandin D2(PGD2) is a bioactive lipid derived from arachidonic acid that aggravates muscle damage and wasting during muscle atrophy. This study aimed to investigate the precise mechanisms underlying PGD2‐mediated muscle homeostasis and myogenesis.MethodsSkeletal muscle‐specific PGD2receptor DP2‐deficient mice (DP2fl/flHSACre) and their littermate controls (DP2fl/fl) were subjected to exhaustive exercise and fed a high‐fat diet (HFD). X‐linked muscular dystrophy (MDX) mice and HFD‐challenged mice were treated with the selective DP2 inhibitor CAY10471. Exercise tolerance, body weight, glycometabolism and skeletal muscle fibre composition were measured to determine the role of the skeletal muscle PGD2/DP2 signalling axis in obesity and muscle disorders. Multiple genetic and pharmacological approaches were also used to investigate the intracellular signalling cascades underlying the PGD2/DP2‐mediated skeletal muscle fibre transition.ResultsPGD2generation and DP2 expression were significantly upregulated in the hindlimb muscles of HFD‐fed mice (P < 0.05 orP < 0.01 vs. normal chow diet). Compared with DP2fl/flmice, DP2fl/flHSACremice exhibited remarkable glycolytic‐to‐oxidative fibre‐type transition in hindlimb muscles and were fatigue resistant during endurance exercise (154.9 ± 6.0 vs. 124.2 ± 8.1 min,P < 0.05). DP2fl/flHSACremice fed an HFD showed less weight gain (P < 0.05) and hepatic lipid accumulation (P < 0.01), reduced insulin resistance and enhanced energy expenditure (P < 0.05) compared with DP2fl/flmice. Mechanistically, DP2 deletion promoted the nuclear translocation of nuclear factor of activated T cells 1 (NFATc1) by suppressing RhoA/Rho‐associated kinase 2 (ROCK2) signalling, which led to enhanced oxidative fibre‐specific gene transcription in muscle cells. Treatment with CAY10471 enhanced NFATc1 activity in the skeletal muscles and ameliorated HFD‐induced obesity (P < 0.05 vs. saline) and insulin resistance in mice. CAY10471 also enhanced exercise tolerance in MDX mice (100.8 ± 8.0 vs. 68.9 ± 11.1 min,P < 0.05 vs. saline) by increasing the oxidative fibre‐type ratio in the muscles (45.1 ± 2.3% vs. 32.3 ± 2.6%,P < 0.05 vs. saline).ConclusionsDP2 activation suppresses oxidative fibre transition via RhoA/ROCK2/NFATc1 signalling. The inhibition of DP2 may be a potential therapeutic approach against obesity and muscle disorders.
Neurocognitive and mental health impact of adrenoleukodystrophy across the lifespan: Insights for the era of newborn screening
Authors: Pierpont Elizabeth I. , Isaia Ashley R. , McCoy Erin , Brown Sarah J. , Gupta Ashish O. , Eisengart Julie B. 
Published: December 2022

AbstractX‐linked adrenoleukodystrophy (ALD) is a rare inherited neurological disorder that poses considerable challenges for clinical management throughout the lifespan. Although males are generally more severely affected than females, the time course and presentation of clinical symptoms are otherwise difficult to predict. Opportunities to improve outcomes for individuals with ALD are rapidly expanding due to the introduction of newborn screening programs for this condition and an evolving treatment landscape. The aim of this comprehensive review is to synthesize current knowledge regarding the neurocognitive and mental health effects of ALD. This review provides investigators and clinicians with context to improve case conceptualization, inform prognostic counseling, and optimize neuropsychological and mental health care for patients and their families. Results highlight key predictive factors and brain‐behavior relationships associated with the diverse manifestations of ALD. The review also discusses considerations for endpoints within clinical trials and identifies gaps to address in future research.
Wound healing after ridge preservation: A randomized controlled trial on short‐term (4 months) versus long‐term (12 months) histologic outcomes
Authors: Zellner Jacob W. , Allen Hunter T. , Kotsakis Georgios A. , Mealey Brian L. 
Published: December 2022

AbstractBackgroundThe amount of time it takes for bone allograft particles to be replaced with new vital bone during ridge preservation is unclear. The purpose of this article was to compare the wound healing and vital bone formation following ridge preservation using a combination allograft of 70% mineralized and 30% demineralized freeze‐dried bone allograft at 4 months (short‐term, ST) versus 12 months (long‐term, LT).MethodsFifty‐seven patients were enrolled in the study who required extraction of a single tooth (excluding second and third molars) and were planned for replacement with a dental implant. After tooth extraction, all sites were grafted with a combination allograft procured from a single donor, and patients were randomized into the ST or LT healing groups. Patients returned for implant placement and an 8‐mm bone core biopsy was harvested using a trephine drill during initial implant osteotomy preparation. The cores were then analyzed histologically to determine the percentages of vital bone formation, residual graft particles, and connective tissue/other.ResultsThere was significantly greater vital bone formation in the LT group (51.38%) compared with the ST group (31.39%) (p = 0.0025) and significantly fewer residual graft particles in the LT group (18.04%) compared with the ST group (40.38%).ConclusionsA longer healing time following ridge preservation results in more vital bone formation and less residual graft particles at the time of implant placement. However, residual allograft material still remains at 12 months after ridge preservation.