bluuebunny/crossref_metadata_2025_split huggingface dataset:
The road to normalization: The importance of the United Arab Emirates' neoliberal foreign policy in the normalization with Israel: 2004–2020
Authors: Traub Daniela , Cohen Ronen A. , Kertcher Chen 
Published: December 2022

AbstractThe article discusses the question of why and how the normalization between the United Arab Emirates (UAE) and Israel took place and managed to evolve into a peace agreement. It offers an additional explanation to the neorealists' scholarly and commonly accepted argument: that it was only the behavior of the revisionist state of Iran that was the motive for signing the peace agreement between the two states. Furthermore, the article argues that the normalization of relations began in 2004 and could have materialized owing to the UAE's neoliberal foreign policy of focusing on soft power cooperation. It suggests the UAE's internal interests of status, stability, and empowerment, which were incorporated in the Vision 2021 plan, were translated into a foreign policy of international cooperation rather than one of military involvement and alliances. The UAE's long‐term strategy reveals a dual neorealist and neoliberal foreign policy with a tendency toward the latter. The neoliberal foreign policy of soft power cooperation attracted the UAE to Israel and, through these shared interests, built trust and eventually led to normalization between the two states. The study covers three periods of the UAE's foreign policy strategy during the development of the normalization process. It begins with the tension between the neoliberal and neorealist strategies from 2004 to 2009, then looks at the increase in tensions between 2010 and 2018, and ends with the focus on the neoliberal foreign policy strategy in 2019–2020.
The influence of government upon multinational company manufacturing location decisions
Authors: Ekhart Gerard , Breese Richard 
Published: December 2022

AbstractWith the rapid changes taking place in international manufacturing, there is a need for new theories linking the drivers for manufacturing location decisions to the influence of government. A Delphi study in 2017 of senior industrialists in Europe from capital intensive, complex technology manufacturing sectors provided evidence on the importance of government‐specific factors for final location decisions. This was because of the influence of government policies as an exogenous factor on the drivers for international manufacturing, including cost effective, flexible supply chains and the use of the new technologies of Industry 4.0, in an uncertain global political climate. The findings are used to develop a new theoretical framework comprising the decision onion and the government policy matrix for multinational company manufacturing location decisions. This systematic approach to the influence of government will assist in the development of policy in the post‐Covid 19 era of transformational change in industrial location strategies.
Demoralizing care: Moral and ethical dilemmas of parenting a young adult who lives with a borderline diagnosis
Authors: O'Dougherty Maureen 
Published: December 2022

AbstractThis article theorizes chronic crises of care parents face concerning how to morally/ethically support their young adult child diagnosed with borderline personality disorder (BPD). Grounded in five years’ attendance at a support group for families living with BPD and interviews with parents, the article asks: In the era of deinstitutionalization of those with mental illness, what are the moral/ethical dimensions of parents’ experiences caring for their young adult? The concept of demoralization and “moral breakdown,” an ethical crisis demanding a resolution, characterizes parents’ experiences. The parents featured convey anguished struggles over what they ought to do in a context where risks are high, and nothing parents do seems right. I suggest that dwelling indefinitely in demoralizing care is untenable and that a state of demoralization emerges as a testimony to the parents’ inability to identify a morally/ethically acceptable resolution to the crises of care.
Effects of hunting on genetic diversity, inbreeding and dispersal in Finnish black grouse (Lyrurus tetrix)
Authors: Chen Rebecca S. , Soulsbury Carl D. , Lebigre Christophe , Ludwig Gilbert , van Oers Kees , Hoffman Joseph I. 
Published: December 2022

AbstractIntensive hunting activities such as commercial fishing and trophy hunting can have profound influences on natural populations. However, less intensive recreational hunting can also have subtle effects on animal behaviour, habitat use and movement, with implications for population persistence. Lekking species such as the black grouse (Lyrurus tetrix) may be especially prone to hunting as leks are temporally and spatially predictable, making them easy targets. Furthermore, inbreeding in black grouse is mainly avoided through female‐biased dispersal, so any disruptions to dispersal caused by hunting could lead to changes in gene flow, increasing the risk of inbreeding. We therefore investigated the impact of hunting on genetic diversity, inbreeding and dispersal on a metapopulation of black grouse in Central Finland. We genotyped 1065 adult males and 813 adult females from twelve lekking sites (six hunted, six unhunted) and 200 unrelated chicks from seven sites (two hunted, five unhunted) at up to thirteen microsatellite loci. Our initial confirmatory analysis of sex‐specific fine‐scale population structure revealed little genetic structure in the metapopulation. Levels of inbreeding did not differ significantly between hunted and unhunted sites in neither adults nor chicks. However, immigration rates into hunted sites were significantly higher among adults compared to immigration into unhunted sites. We conclude that the influx of migrants into hunted sites may compensate for the loss of harvested individuals, thereby increasing gene flow and mitigating inbreeding. Given the absence of any obvious barriers to gene flow in Central Finland, a spatially heterogeneous matrix of hunted and unhunted regions may be crucial to ensure sustainable harvests into the future.
A decade of progress in marine evolutionary biology
Authors: De Wit Pierre , Faust Ellika , Green Leon , Jahnke Marlene , Pereyra Ricardo T. , Rafajlović Marina 
Published: December 2022

AbstractThis article summarizes the Evolutionary Applications Special Issue, “A decade of progress in Marine Evolutionary Biology.” The globally connected ocean, from its pelagic depths to its highly varied coastlines, inspired Charles Darwin to develop the theory of evolution during the voyage of the Beagle. As technology has developed, there has been a dramatic increase in our knowledge about life on our blue planet. This Special Issue, composed of 19 original papers and seven reviews, represents a small contribution to the larger picture of recent research in evolutionary biology, and how such advancements come about through the connection of researchers, their fields, and their knowledge. The first European network for marine evolutionary biology, the Linnaeus Centre for Marine Evolutionary Biology (CeMEB), was developed to study evolutionary processes in the marine environment under global change. Though hosted by the University of Gothenburg in Sweden, the network quickly grew to encompass researchers throughout Europe and beyond. Today, more than a decade after its foundation, CeMEB's focus on the evolutionary consequences of global change is more relevant than ever, and knowledge gained from marine evolution research is urgently needed in management and conservation. This Special Issue, organized and developed through the CeMEB network, contains contributions from all over the world and provides a snapshot of the current state of the field, thus forming an important basis for future research directions.
Encountering Berlant part two: Cruel and other optimisms
Authors: Anderson Ben , Awal Akanksha , Cockayne Daniel , Greenhough Beth , Linz Jess , Mazumdar Anurag , Nassar Aya , Pettit Harry , Roe Emma J. , Ruez Derek , Salas Landa Mónica , Secor Anna , Williams Aelwyn 
Published: December 2022

AbstractPart 2 of Encountering Berlant amplifies the promise of Lauren Berlant's influential concept of ‘cruel optimism’. Cruel optimism names a double‐bind in which attachment to an ‘object’ holds out the promise of sustaining/flourishing, whilst simultaneously harming. The lines between harming, sustaining, damaging and flourishing blur, sometimes collapsing entirely. By holding together opposites the concept exemplifies and performs the centrality of ambivalence to Berlant's thought, as well as their orientation to overdetermination and incoherence. Geographers and others have found in the concept a way of understanding the intersection between affective and political economies in the crisis‐present following the 2008 financial crisis. Together with Berlant's linked concepts such as ‘crisis ordinariness’ and ‘impasse’, cruel optimism has offered a way of understanding why detachment can be so difficult and how damaging conditions endure. Contributors begin from these starting points, amplifying the concept's promise: a new way of researching and writing about the reproduction of ordinary damage and harm. By writing from diverse encounters with Berlant's work, they move the concept in multiple directions, juxtaposing it with other optimisms across a variety of empirical scenes and locations. The result is a repository of what cruel optimism, and Berlant's mode of thinking‐feeling more broadly, offer geographers and others.
Money down the drain: Corruption and water service quality in Africa
Authors: Breen Michael , Gillanders Robert 
Published: December 2022

AbstractUsing data from the seventh round of the Afrobarometer, we find that a greater regional incidence of corruption in the utilities sector is associated with a reduced likelihood that a household reports that it has access to enough clean water. This result is not evident in older rounds of the survey that were conducted prior to methodological improvements made in round seven. Moreover, this association holds only in areas with a piped water system. Thus, our findings are consistent with the argument that corruption is a barrier to accessing water through its impact on the quality of water services. While a household that has paid a bribe is more likely to have a water access point, the regional incidence of utilities corruption predicts that the household will not have enough clean water. Individual acts of bribery, while associated with connection to a water network, are not associated with greater access in reality.
The influence of the COVID‐19 pandemic on changes in perceived work pressure for Dutch mothers and fathers
Authors: André Stéfanie , van der Zwan Roos 
Published: December 2022

AbstractAs a result of the first COVID‐19 lockdown in the Netherlands in March 2020, more than half of parents in the Netherlands had to work from home while also caring for their children. We found that work‐related stressors and resources (working more hours, realistic manager expectations) particularly affect perceived work pressure. Perceived work pressure was higher among egalitarian fathers and mothers, especially compared to traditional fathers and mothers. Furthermore, egalitarian fathers were more negatively affected by arguments with their partners (home stressor) than traditional fathers. We found no differences between traditional and egalitarian mothers.
Primary prophylaxis in children with severe haemophilia A and B—Implementation over the last 20 years as illustrated in real‐world data in the PedNet cohorts
Authors: Ljung Rolf , de Kovel Marloes , van den Berg H. Marijke ,   the PedNet study group
Published: December 2022

AbstractIntroductionThe prophylactic regimen in children with severe haemophilia is suggested in various publications and guidelines. Few data exist on its implementation in clinical practice.AimTo investigate the implementation of primary prophylaxis based on real‐life data from PedNet during the last 20 years.MethodsAll children from the PedNet cohort (n = 1260) with severe haemophilia A (SHA) or severe haemophilia B (SHB), FVIII/IX < .01 IU/mL, born between 2000 and 2009 (Cohort I; SHA n = 662; SHB n = 88) and 2010–2019 (Cohort II; SHA n = 598; SHB n = 94) were included.ResultsIn SHA, the median age at start of prophylaxis was 17.3 months (IQR; 12.5–26.1) in Cohort I which decreased to 13.1 months (IQR; 10.4–19.1) in Cohort II (p < .000). “Once‐a‐week” prophylaxis at start increased from 49% to 68% (SHA) and 38% to 70% (SHB). FVIII doses were reduced from median 43.5 (IQR; 34.6–49.0) to 30.9 IU/kg (IQR; 26.3–46.3), while dosing with FIX did not change. After 2010 approximately 60% of the patients with SHA and SHB started prophylaxis before any joint bleed. The number of CVADs needed in both cohorts was around 30%. Incidences of inhibitors were unchanged: SHA (∼31%) and SHB (∼10%). Sporadic cases were diagnosed significantly later (median 8.3 months; IQR; 3.7–11.9) and they had more joint bleeds before start of prophylaxis.ConclusionPrimary prophylaxis nowadays starts at an earlier age: before any joint bleed (60% of patients with SHA and SHB). Approximately 70% started on a once‐weekly schedule with significantly reduced doses in SHA but unchanged in SHB.
Molecular spectrum of inherited FVII deficiency in North India revealed a recurrent variant with a founder effect
Authors: Sharma Ritika , Jamwal Manu , Senee Hari Kishan , Singh Namrata , Kumar Narender , Hans Chander , Kler Anita , Bansal Deepak , Trehan Amita , Malhotra Pankaj , Ahluwalia Jasmina , Das Reena 
Published: December 2022

AbstractIntroductionInherited Factor VII (FVII) deficiency is commonest among the rare bleeding disorders. A small number of patients present in infancy with severe bleeding, and many may remain asymptomatic but detected before surgery/invasive procedures. Genetic testing may be helpful in predictive testing/prenatal diagnosis in severe cases.AimCharacterisation of clinical and genotypic spectrum of patients with inherited FVII deficiency.MethodsRetro‐prospectively, 35 cases with prolonged prothrombin time and FVII activity (FVII:C) <50 IU/dl were subjected to targeted resequencing. After in‐silico analysis, variant/s were validated by Sanger sequencing in index cases and family members. Haplotype analysis was done for F7 polymorphisms.ResultsSevere FVII deficiency was found in 50% of patients (FVII:C ≤1 IU/dl), and 42.9% were asymptomatic. Clinical severity assessment revealed 17% severe, 17% moderate and 22.9% patients with mild bleeds. FVII levels ranged from .3 to 38 IU/dl. Molecular analysis revealed variants in 30/35 cases, of which 17 were homozygous, 10 were compound heterozygous and 3 were heterozygous. Twelve genetic variants were identified, one promoter variant c.‐30A>C; seven missense (c.215C>G, c.244T>C, c.253G>C, c.904G>A, c.961C>T, c.1109G>T, c.1211G>A), two deletions (c.21delG, c.868_870delATC), and one each of nonsense c.634C>T and splice‐site variant c.316+1G>A. Recurrent variants c.1109G>T and c.215C>G were found in 17 and 8 cases, 12 of the former cases were homozygous. They had the same haplotype, indicating the founder effect in North Indians.ConclusionThis is the largest cohort of FVII genotyping from India, confirming heterogeneity in terms of clinical manifestations, FVII activity and zygosity of the variants with a limited genotypic phenotypic correlation.
Comparison of microscopy and metabarcoding to identify pollen used by the critically endangered rusty patched bumble bee, Bombus affinis
Authors: Simanonok Michael P. , Iwanowicz Deborah D. , Raines Clayton D. , Wood Thomas J. , Isaacs Rufus , Cornman Robert S. , Otto Clint R. V. 
Published: December 2022

Abstract
Taxonomic analysis of pollen collected by bees can provide insights into their host plant use, providing information about the plant species selected for targeted conservation strategies. The two main identification approaches used are morphological analysis of pollen samples affixed to microscope slides (i.e., microscopic palynology) and molecular analysis of samples. Both methods are widely used for freshly collected materials and have been compared in multiple studies, yet their application to archived samples remains to be explored. Archived samples may be particularly useful for the study of rare or protected species, particularly when historical foraging patterns are uncertain.
We used both methods to analyse pollen collected by the endangered rusty patched bumble bee species, Bombus affinis Cresson, applied to museum‐archived specimens. Pollen samples were removed from the corbiculae of bumble bees originally collected in Michigan between 1914 and 1974. Samples included 24 rusty patched bumble bees each with large pollen loads on both corbiculae, allowing for pollen from the same bee to be analysed using both methods.
DNA metabarcoding detected more plant taxa than light microscopy, and DNA barcoding also had higher taxonomic resolution when compared to taxa determined using light microscopy. In many instances, pollen could only be confidently identified to tribe or family with light microscopy. Discrepancy between methods decreased when taxa identified via DNA metabarcoding were binned into ecologically relevant groups corresponding to those identified using light microscopy.
Although binning demonstrated smaller within‐method variance, there was still minimal correspondence between the two methods. Results indicate there are benefits and biases unique to each method and highlight the utility of binning taxonomic results to morphological or ecological groupings.
A C2H2 zinc finger transcription factor of the whitefly Bemisia tabaci interacts with the capsid proteins of begomoviruses and inhibits virus retention
Authors: Ghosh Saptarshi , Srinivasan Rajagopalbabu , Ghanim Murad 
Published: December 2022

AbstractBegomoviruses are a group of ssDNA viruses exclusively transmitted by the whitefly Bemisia tabaci and constrain vegetable production in the old and new worlds. Although multiple molecular determinants governing the transmission of begomoviruses by whiteflies have been unravelled, factors critical for transmission majorly remain unknown. In this study, a whitefly C2H2 zinc finger (ZF) protein, 100% identical to the vascular endothelial ZF‐like gene (vezf) protein was confirmed to interact with the CP of both old‐ and new‐world begomoviruses. This was achieved by a yeast two‐hybrid (Y2H) system screening of a whitefly cDNA library using capsid protein (CP) of TYLCV as a bait. In silico annotation of vezf protein revealed that it contains a N‐terminal ZF‐associated domain (ZAD) alongside multiple C2H2 ZF domains on the C‐terminal end. ZAD‐ZF proteins form the most abundant class of transcription factors within insects. Herein, we validated the interaction of vezf with four diverse begomoviruses and its functional role in begomovirus transmission. Silencing of the vezf gene of B. tabaci led to increased retention of three diverse begomoviruses tested. Vezf is the first insect transcription factor identified to interact with plant viruses and can be crucial to understand the possible mechanisms by which plant viruses modulate transcription of their insect vectors during transmission.
FLU‐LISA (fluorescence‐linked immunosorbent assay): high‐throughput antibody profiling using antigen microarrays
Authors: Levy Shlomia , Abd Alhadi Marwa , Azulay Asaf , Kahana Amit , Bujanover Nir , Gazit Roi , McGargill Maureen A , Friedman Lilach M , Hertz Tomer 
Published: December 2022

AbstractVaccination and natural infection both elicit potent humoral responses that provide protection from subsequent infections. The immune history of an individual following such exposures is in part encoded by antibodies. While there are multiple immunoassays for measuring antibody responses, the majority of these methods measure responses to a single antigen. A commonly used method for measuring antibody responses is ELISA—a semiquantitative assay that is simple to perform in research and clinical settings. Here, we present FLU‐LISA (fluorescence‐linked immunosorbent assay)—a novel antigen microarray‐based assay for rapid high‐throughput antibody profiling. The assay can be used for profiling immunoglobulin (Ig) G, IgA and IgM responses to multiple antigens simultaneously, requiring minimal amounts of sample and antigens. Using several influenza and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) antigen microarrays, we demonstrated the specificity and sensitivity of our novel assay and compared it with the traditional ELISA, using samples from mice, chickens and humans. We also showed that our assay can be readily used with dried blood spots, which can be collected from humans and wild birds. FLU‐LISA can be readily used to profile hundreds of samples against dozens of antigens in a single day, and therefore offers an attractive alternative to the traditional ELISA.
Understanding the contribution of general medical services to acute inpatient care in Victorian public hospitals
Authors: Gorman Andrew Christopher , Newnham Harvey H. , Potter Elizabeth L. , Busija Lucy , Aung Ar Kar 
Published: December 2022

AbstractBackgroundGeneral medicine is an integral part of health services, yet there is little data highlighting their contribution to acute hospital care in Australia.AimsTo utilise the Victorian Department of Health's administrative dataset for hospital admissions to evaluate the relative contribution and trends over time of general medical services to acute multiday inpatient hospital separations in the Victorian public healthcare system.MethodsA retrospective time‐series study of general medical activity compared to other major specialties using hospital‐level data provided by the Department of Health: (i) extrapolation from diagnosis‐related group (DRG) activity data (2011–2021) and, (ii) directly reported discharge unit‐based activity (available from 2018). Acute multiday separations of all patients aged ≥18 years from all metropolitan and rural Victorian public hospitals were included.ResultsUsing the DRG‐based data, general medicine ranked as the largest care provider of all specialties studied, accounting for 12.1% of separations. Despite the largest increase at a rate of 2831 separations/year (0.336%/year of total, P < 0.001) compared to others, mean length of stay declined by 0.08 days/year (P < 0.001). These findings were significant for metropolitan and rural hospitals. The use of directly reported discharge unit‐based data also ranked general medicine as the largest care provider accounting for 32.9% of total separations, with rural hospital general medical services contributing nearly 50% of all multiday separations.ConclusionsBoth DRG‐based data and discharge unit‐based data indicate that general medicine is the largest provider of acute multiday inpatient care in Victorian hospitals. The estimate of contribution of general medicine differed between the two datasets as DRG data likely over‐represents the role of other specialties possibly due to assumptions regarding specialty management of varying groups of diagnoses.