bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the construction of a human-water harmony model in the Yellow River Basin
Authors: Shi Yan , Yang Shipeng , Chen Weiwei , Wang Xin , Feng Changping 
Published: July 2023

Abstract

Human-water harmony in the Yellow River Basin has an important influence on promoting ecological protection and high-quality development in the Yellow River Basin. This paper explores the degree of harmony between humans and water in the provinces of the Yellow River Basin. Based on the provincial-level data of nine provinces from 2001 to 2020, a human-water harmonious coupling coordination degree model was constructed, and the spatial and temporal analysis of the coupling coordination characteristics of nine provinces was carried out utilizing ArcGIS software. The results revealed that: (1) From the point of view of human-water harmony, from 2001 to 2020, China's human-water relationship was on the rise, from reluctant coupling coordination to good coupling coordination. (2) Qinghai, Gansu, and Sichuan provinces have the most significant increase in human-water harmony, from on the verge of a dysfunctional decline to quality coupling coordination. (3) From 2001 to 2011, the human system's comprehensive index was inferior to that of the water system's comprehensive index. In 2003, the comprehensive index of human and water systems was the largest. From 2012 to 2020, the human system's comprehensive index was higher than the water system. However, in 2015, the two indices diverged significantly
A comparative study of several types of indices for river quality assessment
Authors: Gil-Rodas Norma , Guevara-Mora Meyer , Rivas Gabriel , Dávila Gabriela , García Doris , Contreras-Perdomo Alejandra , Alvizures Pride , Martínez Mónica , Calvo-Brenes Guillermo 
Published: July 2023

Abstract

Water is vital for humans, plants, and animals; unfortunately, some anthropogenic activities adversely alter water quality (WQ). Many indicators can be used for WQ assessment; fortunately, extensive data can be simplified by using WQ indices (WQIs). The main difference among WQIs lies in the way of assessing pollution and the number and types of WQ indicators used; therefore, the selection of a reliable WQI should be the first step. This research aimed to compare several types of indices and evaluate their effectiveness. Eighteen sampling sites were monitored, and the selected indices showed different results. Biological indices exhibited a significant statistical correlation and yet different quality results. In addition, biological WQIs showed different outcomes from the physicochemical index. The high concentrations of phosphates, fecal coliforms, and biological oxygen demand, found in most rivers, were responsible for adversely influencing the quality results of the physicochemical index; however, their high concentrations found in some sampling sites had no adverse effect on the macroinvertebrate's existence; therefore, biological WQ assessment showed better quality results than the physicochemical index. The Rapid Bioassessment Protocol index, based on visual habitat observations, proved to be an easy way to classify WQ and an adequate replacement for biological indices.
Transport and interaction of cadmium and active sludge extracellular polymeric substances in saturated sand influenced by ionic strength and composition
Authors: Meng Qingling , Shi Fuqiang , Zhong Peng , Fan Wei , Xue Honghai , Jiang Yan 
Published: July 2023

Abstract

Artificial groundwater recharge with reclaimed water (secondary effluent from wastewater treatment plants) has become an important approach to solving water scarcity worldwide. Microorganisms in activated sludge can secrete many extracellular polymeric substances (EPS). However, information on the impact of EPS on the movement of heavy metals in porous media and their environmental effects on underground networks is limited. To assess this risk, we extracted EPS from the aerobic section of a wastewater treatment plant using hot sodium hydroxide and conducted experiments using one-dimensional sand columns to investigate how ion composition and strength affect the movement and interaction of cadmium (Cd) and EPS in porous media. The results showed that EPS facilitated Cd migration in porous media. Sodium (Na) and calcium (Ca) ions promoted the migration of Cd in porous media and EPS–Cd complexation. The effect of Ca was more significant than that of Na. As the Na adsorption ratio increased, the migration ability of Cd in porous media and the complexation ability of EPS with Cd decreased. Therefore, when estimating the migration of EPS and Cd in subsurface environments, careful consideration should be given to prevent the risk of groundwater pollution.
Effect of Different Desensitizing Protocols on Pulp Inflammatory Responses in Whitened Teeth: A Randomized Clinical Trial
Authors: Oliveira Barros Antonia Patricia , de Mendonça Raissa Pinheiro , de Melo Alencar Cristiane , Pinheiro João de Jesus Viana , Rothbarth Cláudia Pires , de Melo Alves Júnior Sérgio , Silva Cecy Martins 
Published: July 2023

Purpose:
This randomized controlled, blind clinical trial evaluated the efficacy of different desensitizing protocols in preventing pulp inflammation after whitening treatment with hydrogen peroxide (HP) at 35% (Whiteness HP 35%).

Materials and Methods:
Thirty healthy third human molars extracted by orthodontic indication were randomized and allocated into five groups (n=5): NC (negative control): without intervention; PC (positive control): HP; PBM: HP + photobiomodulation with a Watts LASER; CPP: HP + casein phosphopeptide amorphous calcium phosphopeptide (CPP-ACP); and NANO: HP + nano-hydroxyapatite. The in-office whitening was performed in two sessions with a single 45 minutes application at an interval of 48 hours. Pulp tissues were extirpated for immunohistochemical analysis. Immunoreaction for activated caspase-3 was observed, and images were acquired using an Axio Scope A1 microscope. The Kruskal-Wallis test was used to evaluate the immunoexpression of caspase-3.

Results:
Comparisons between the PC and NC groups revealed a statistically significant difference (p<0.05) for the analysis of caspase-3 immunoexpression. A statistically significant difference (p<0.05) was also observed for the CPP and PBM groups in relation to the PC.

Conclusion:
Photobiomodulation and CPP-ACP are promising alternatives to minimize pulpal inflammation induced by tooth whitening.

Clinical Trial Registration Number:
NCT04548674.
Impact of Socioeconomic Disparities, General Health, Reproductive, and Exercise Status in Indian Women with Lumbopelvic Pain
Authors: Sushil Priyanka , Chawla Jasmine K. , Parasher Raju K. 
Published: July 2023

Background:
Evidence suggests links between several health conditions and lumbopelvic pain (LPP) in women beyond the commonly associated musculoskeletal origins of LPP.

Objective:
This study explored the association of LPP with general health conditions, stress, exercise, and socioeconomic status in Indian women.

Methods:
In a cross-sectional study, 500 urban women from diverse socioeconomic backgrounds were asked to fill out a self-report questionnaire that sampled their health and reproductive status.

Results:
Women sampled were in the age range of 18-62 years. Overall, the prevalence of LPP was found to be 76.8% and was predominantly observed in women from the lower socioeconomic strata (70.5%), compared to women from the higher strata (29.4%). Multivariate logistic regression identified gynecological issues, such as menstrual problems (O.R.= 472.86, p<0.0001); polycystic ovarian syndrome (O.R.= 125.04, p=0.010); and health issues, such as urinary incontinence (O.R.=3078.24, p=0.001); chronic cough (O.R.= 84.97, p<0.0001); stress (O.R.= 474.27, p<0.0001) as being significantly related to LPP. Additionally, ‘no exercise’ (O.R.= 360.15, p <0.0001) was also strongly associated with LPP.

Conclusion:
Our data suggest that LPP is a significant problem in Indian women, with a greater prevalence in women from the lower strata of society. Importantly, given that several general, gynecological health issues, psychological stress, and a lack of exercise are associated with it, there is a need for LPP sensitization at a community and public health level. Regarding its prevention and long-term management, it is important to rule out and consider the impact of these factors on LPP, beyond its musculoskeletal origins.
Comprehensive Ontology of Fibroproliferative Diseases: Protocol for a Semantic Technology Study
Authors: Golec Marcin , Kamdar Maulik , Barteit Sandra 
Published: July 2023

Background
Fibroproliferative or fibrotic diseases (FDs), which represent a significant proportion of age-related pathologies and account for over 40% of mortality in developed nations, are often underrepresented in focused research. Typically, these conditions are studied individually, such as chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis (IPF), rather than as a collective entity, thereby limiting the holistic understanding and development of effective treatments. To address this, we propose creating and publicizing a comprehensive fibroproliferative disease ontology (FDO) to unify the understanding of FDs.

Objective
This paper aims to delineate the study protocol for the creation of the FDO, foster transparency and high quality standards during its development, and subsequently promote its use once it becomes publicly available.

Methods
We aim to establish an ontology encapsulating the broad spectrum of FDs, constructed in the Web Ontology Language format using the Protégé ontology editor, adhering to ontology development life cycle principles. The modeling process will leverage Protégé in accordance with a methodologically defined process, involving targeted scoping reviews of MEDLINE and PubMed information, expert knowledge, and an ontology development process. A hybrid top-down and bottom-up strategy will guide the identification of core concepts and relations, conducted by a team of domain experts based on systematic iterations of scientific literature reviews.

Results
The result will be an exhaustive FDO accommodating a wide variety of crucial biomedical concepts, augmented with synonyms, definitions, and references. The FDO aims to encapsulate diverse perspectives on the FD domain, including those of clinicians, health informaticians, medical researchers, and public health experts.

Conclusions
The FDO is expected to stimulate broader and more in-depth FD research by enabling reasoning, inference, and the identification of relationships between concepts for application in multiple contexts, such as developing specialized software, fostering research communities, and enhancing domain comprehension. A common vocabulary and understanding of relationships among medical professionals could potentially expedite scientific progress and the discovery of innovative solutions. The publicly available FDO will form the foundation for future research, technological advancements, and public health initiatives.

International Registered Report Identifier (IRRID)
PRR1-10.2196/48645
mHealth Self-Monitoring Model for Medicine Adherence of Patients With Diabetes in Resource-Limited Countries: Structural Equation Modeling Approach
Authors: Kgasi Mmamolefe , Chimbo Bester , Motsi Lovemore 
Published: July 2023

Background
The COVID-19 pandemic has led to serious challenges and emphasized the importance of using technology for health care operational transformation. Consequently, the need for technological innovations has increased, thus empowering patients with chronic conditions to tighten their adherence to medical prescriptions.

Objective
This study aimed to develop a model for a mobile health (mHealth) self-monitoring system for patients with diabetes in rural communities within resource-limited countries. The developed model could be based on the implementation of a system for the self-monitoring of patients with diabetes to increase medical adherence.

Methods
This study followed a quantitative approach, in which data were collected from health care providers using a questionnaire with close-ended questions. Data were collected from district hospitals in 3 South African provinces that were selected based on the prevalence rates of diabetes and the number of patients with diabetes treated. The collected data were analyzed using smart partial least squares to validate the model and test the suggested hypotheses.

Results
Using variance-based structural equation modeling that leverages smart partial least squares, the analysis indicated that environmental factors significantly influence all the independent constructs that inform patients’ change of behavior toward the use of mHealth for self-monitoring of medication adherence. Technology characteristics such as effort expectancy, self-efficacy, and performance expectancy were equally significant; hence, their hypotheses were accepted. In contrast, the contributions of culture and social aspects were found to be insignificant, and their hypotheses were rejected. In addition, an analysis was conducted to determine the interaction effects of the moderating variables on the independent constructs. The results indicated that with the exception of cultural and social influences, there were significant interacting effects on other independent constructs influencing mHealth use for self-monitoring.

Conclusions
On the basis of the findings of this study, we conclude that behavioral changes are essential for the self-monitoring of chronic diseases. Therefore, it is important to enhance those effects that stimulate the behavior to change toward the use of mHealth for self-monitoring. Motivational aspects were also found to be highly significant as they triggered changes in behavior. The developed model can be used to extend the research on the self-monitoring of patients with chronic conditions. Moreover, the model will be used as a basic architecture for the implementation of fully fledged systems for self-monitoring of patients with diabetes.
Pengetahuan Masyarakat Tentang Penggunaan Suplemen Vitamin untuk Meningkatkan Imunitas Tubuh Selama Pandemi COVID-19 di Kelurahan Klender, Jakarta Timur dan Kecamatan Panimbang, Banten
Authors: Maifitrianti Maifitrianti , Wiyati Tuti , Zaid Liesca Tria Novalita , Bahiah Faridatul 
Published: July 2023

Numerous Vitamins have an important role in maintaining the immune system and reducing the risk of COVID-19 infection. This study aimed to determine the level of public knowledge regarding vitamin supplements used during the COVID-19 pandemic to improve the immunity system and associated factors among the community of Klender sub-district, East Jakarta and Panimbang sub-district, Banten. This study was performed from August to October 2021. This study method was observational with cross sectional design. Respondent’s data included home town, gender, age, education level, occupation, place of obtaining vitamin supplements, types of vitamin supplements consumed and sources of information regarding vitamin supplements were obtained from the questionnaire. Knowledge level assessment was carried out using a validated questionnaire. The respondents of this study were 804 people. Most of the respondents were aged 18-25 years (48.3%) and female (60.9%). The results showed that the majority of respondents had a good level of knowledge (70.5%). The bivariate analysis using the chi square test showed that the level of knowledge was related to the level of education (p<0.005).
Knowledge of Cardiovascular Disease and its Association Among General Population in Indonesia
Authors: Anggelina Bella , Kristina Susi Ari , Wiedyaningsih Chairun 
Published: July 2023

Knowledge of cardiovascular disease is essential for providing information about healthy behavior and to be proactive in reducing modifiable risk factors, control prevention, and improving early recognition. The existing study about knowledge of CVD in Indonesia is still limited. Hence, this study aimed to describe knowledge of CVD among general population in Indonesia and its association. A cross-sectional survey was conducted in 34 provinces in Indonesia from November-December 2021. Data were retrieved using a self-administered questionnaire. The Chi-Square analysis was performed to determine the association that contributes to overall knowledge of CVD. Among the 694 participants, 32.1% originated from Java, with the median age was 24 years and dominated by women (72.5%). The mean score of overall CVD knowledge was 59.6%, and only 39.1% of the participants had good knowledge of CVD. Cerebrovascular disease (94.7%) was the most identified various type of CVD. Likewise, unhealthy diet (77.2%), obesity (74.6%), and lack of exercise (72.5%) were the most identified risk factors. More than 50% of the participants recognized heart attack symptoms such as chest pain (77.1%) and shortness of breath (66.1%). Meanwhile, numbness or weakness (84.7%), trouble speaking (76.9%), and loss of balance (72.3%) were recognized as stroke symptoms. Gender, age, education level, working status, healthy food, smoking status, family history of CVD, ever checked blood pressure, fasting blood glucose, and total cholesterol were associated with overall knowledge of CVD. The disparity between level of CVD knowledge is not prominent among general population in Indonesia and further study need to establish.
Dampak Konteks Internal dan Eksternal terhadap Creating Shared Value (CSV) Perusahaan Energi Terbarukan
Authors: Hutomi Luthfi Muhammad 
Published: July 2023

Penelitian ini bertujuan untuk menggali aspek kontekstual yang memengaruhi implementasi program CSV. Dengan pemahaman yang dalam mengenai CSV dan elaborasi terhadap konteksnya, penelitian kualitatif eksploratif dengan desain studi kasus ini berusaha mendalami program CSV Kamojang Desa Digital yang dijalankan oleh PT Pertamina Geothermal Energi (PGE) Area Kamojang dari perspektif perencana dan pelaksana program. Hasil penelitian menunjukkan bahwa meskipun CSV merupakan mandat PT Pertamina (Persero), implementasinya mengalami translasi sehingga menghadirkan konsepsi yang memiliki distingsi dengan gagasan aslinya. Dari tiga subprogram yang diteliti, hanya Geotato dan Rangers App yang dapat dikategorikan sebagai CSV dengan model redefinisi rantai nilai perusahaan. Terdapat tujuh konteks yang berhasil diabstraksi, yakni kapasitas perusahaan dalam berjejaring, kepatuhan terhadap regulasi, budaya CSV perusahaan, kapabilitas menciptakan inovasi, dinamika produktivitas komoditas lokal, kendala kompetensi, dan keberlanjutan ekologis. Ketujuh konteks tersebut terkait dengan konteks pembangunan desa di Indonesia yang mengalami disparitas dalam pelayanan publik dan limitasi akses terhadap teknologi modern.
Kata kunci: konteks CSV, disparitas pelayanan publik, limitasi akses teknologi
Abstract
This study aims to explore contextual aspects that affect the implementation of the CSV program. Conceptualizing of CSV and its context, this exploratory qualitative research with a case study design has investigated the Kamojang Desa Digital CSV program run by PT PGE Area Kamojang from the planners’ and implementers’ perspectives. The results show that, although CSV is a mandate from PT Pertamina (Persero), its implementation is examined through translation that presents distinctive conception of the original idea. Of the three subprograms, only Geotato and Rangers App can be categorized as CSV with redefinition of the value chain model. Seven contexts have been abstracted: company capacity in networking, regulatory compliance, corporate CSV culture, capability to create innovation, dynamics of local commodity productivity, competency constraints, and ecological sustainability. Those are related to the context of village development in Indonesia, which is experiencing disparities in public services and limited access to modern technology.

Keywords: CSV context, public service disparities, technological access limitations
Experiences of Children Living in Overcrowded Homes: A Case of Ghana
Authors: Adu Henaku Eugene 
Published: July 2023

The study explored children's experiences living in overcrowded homes in Apewosika Community, a suburb of the Cape Coast Metropolis in the Central Region of Ghana. The descriptive phenomenological research design was adopted for the study. A face-to-face interview was used to collect data from 10 participants aged 12-17 years. These participants were purposively sampled from 10 nuclear families based on the inclusion criteria. The thematic data analysis method was used in analysing the data collected. The themes that emerged from the data analysis are lack of privacy, sleep disturbance, difficulty studying at home, and the spread of diseases. The study concludes that enough space should be provided at home for children to have rooms to reduce the spread of infectious diseases among children and their family members, promote sleep, ensure their privacy and promote their studies at home.
Keywords: Children, Ghana, Housing, Overcrowded Homes
Genetic polymorphisms of DPYD in patients with breast cancer on capecitabine therapy
Authors: Abbas Raaid Fadhl , Sahib Ahmed Salih , Mahmood Hasanain Shakir , Mohsin Karar Kadhim , Majeed Ali Amal Aldeen 
Published: July 2023

Objectives: Breast cancer is the primary cause of death in Iraqi women aged 30–54 years. The study examined the relationship between (G > A) (rs3918290) and (rs55886062, T >G) DPYD gene polymorphisms, their haplotypes, and capecitabine serum concentrations in postmenopausal Iraqi women with breast cancer in postmenopausal women. During capecitabine chemotherapy.
Methods: The study included 200 women: 100 apparently health (45-75 years old) and 100 with breast cancer (40-70 years old). This study, conducted between July and October 2022 at the oncology centre at Imam al-Hussain medical city in Kerbala, Iraq, plasma levels of Capacetabine and 5fu were measured in breast cancer patients who had been taking capecitabine for at least three months. All participants gave informed consent.
Results: Capecitabine, and 5FU concentrations in breast cancer patients differed significantly, As the results showed, Capecitabine, and 5FU had a significantly higher concentration of them in patients with the TT allele than in those with the CC and CT alleles for the polymorphism (IVS14 + 1G > A) (rs3918290) and in patients with DPYD*13 (rs55886062) with the CC allele rather than the AA and AC alleles. Mutant allele carriers had increased Capecitabine concentrations (p<0.001).
Conclusion: Ca15.3, serum calcium, and estradiol all exist in bodily serum, making them a potentially useful novel diagnostic biomarker for patients with breast cancer due to their high levels of stability, as well as the biological properties of tumors, such as serum calcium and estrogen.