bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support during re-entry period and long-term quality of life in breast cancer survivors: A 10-year longitudinal cohort study
Authors: Cho HyeonJin , Kang Danbee , Shin Dong Wook , Kim Nayeon , Lee Se Kyung , Lee Jeong Eon , Nam Seok Jin , Cho Juhee 
Published: June 2023

Abstract

Purpose This study evaluated the association between social support during the re-entry period and long-term HRQoL in breast cancer survivors using a longitudinal cohort study. Methods This is a prospective cohort study with 275 breast cancer survivors who reported HRQoL at 5 and 10 years after surgery. Social support for the re-entry period was assessed using the Medical Outcome Study-Social Support Survey (MOS-SSS). HRQoL was evaluated using EORTC QLQ-C30 and BR-23. Multivariable linear regression analysis was performed to evaluate HRQoL at 5 and 10 years after diagnosis by level of social support during the re-entry period. Results The mean (SD) of social support during re-entry period was 68.5. The low social support group (LSS, score < 55) during the re-entry period had a significantly lower HRQoL (mean difference = -12.93) compared to moderate or high social support group (MHSS, score ≥ 55). Five and ten years after diagnosis, the LSS group continued to demonstrate lower HRQoL (5 years: -7.17; 10 years: -7.85) compared to the MHSS group. LSS group were more likely to have lower role and social function scores, and higher fatigue, pain, and financial problems compared to the MHSS group at 10 years after diagnosis. Conclusions Breast cancer survivors who received lower social support during the re-entry period were more likely to experience poorer HRQoL in the long term than those who did not.
Dorsoulnar injury of the TFCC: clinical features, diagnosis, and treatment
Authors: Wang Liang , Raza Mazhar Ali , Lin Yuhan , Xia Chuanpeng , Zhang Zhang , Yan Hede 
Published: June 2023

Abstract
Introduction
TFCC lesions are commonly categorized according to the classification system proposed by Andrew K. Palmer in 1989, which received a lot of attention in recent years due to the development of wrist arthroscopy. However, various investigations highlighted other types of lesions that are not listed in this system. This article aims to describe the clinical features, diagnosis, and treatment of the dorsoulnar TFCC injury, a new type of TFCC lesion that is not included in the Palmer’s classification.
Patients And Methods
We investigated 68 patients with dorsoulnar TFCC injuries treated with wrist arthroscopy-assisted suture anchor repair. A retrospective review of all cases was performed to assess the clinical manifestations, physical examination, magnetic resonance imaging, and intraoperative findings. In addition, patients were evaluated at greater than 1 year with a range of motion, grip strength, standard outcome measures.Before and after surgery, we measured subjective results using the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. The functional outcome was calculated by the Mayo Wrist Score.And a survey assessing return to work and sports.
Results
All patients complained of dorsoulnar side wrist pain before surgery. Most of them got a history of trauma, which was not very drastic. The mean age of the patients (30 male and 38 female) at the time of surgery was 39.72 ± 12.6 years. No major complications occurred during surgery and follow-up. Pain perception (VAS: preoperatively 2.96 ± 1.01 vs. Postoperatively 0.09 ± 0.29, p < 0.05) improved significantly. The result of grip strength (preoperatively 25.92 ± 7.18 vs. postoperatively 34.25 ± 10.43, p < 0.05) was satisfactory after surgery. The percentage of grip strength on the affected side compared with that on the healthy side was 0.79 ± 0.10. The DASH score improved significantly (preoperatively 47.98 ± 10.31 vs. Postoperatively 6.35 ± 4.53, p < 0.05). The mean Mayo Wrist Score was 89.41 ± 8.26 at follow-up. Overall, the wrist functions of 59 (86.76%) (excellent: 31, Good: 28) of the patients were satisfactory according to their modified Mayo wrist scores. There was 1 Suture anchor loosening that required repeat surgery. There were no cases of distal radioulnar joint instability at the final follow-up.
Conclusions
Dorsoulnar damage of the TFCC is not so rare in clinical settings. The combination of clinical manifestations and preoperative physical examination maneuvers, preoperative MR images, and arthroscopic observation provide a definite diagnosis of this type of TFCC injury. We name this new pattern of injury as Palmer 1E lesion. Furthermore, the repair of this type of TFCC tears using suture anchors assisted by wrist arthroscopies is safe and simple with good results.
Hybrid Quantum-Classical Approach: Quantum-Inspired Deep Learning Using Classical Simulation
Authors: Farshi Esmaeil 
Published: June 2023

Abstract
In this groundbreaking investigation, we delve into the fertile intersection of quantum mechanics and deep learning, introducing a unique hybrid quantum-classical approach that holds promising implications for the advancement of Artificial Intelligence (AI). Expanding upon the Deep Learning algorithm, we put forth Quantum Deep Learning (QDL), an innovative methodology that synergistically intertwines quantum principles with deep learning algorithms, facilitated by simulation on classical computational platforms. Through this intricate blend, we aim to harness the colossal computational prowess of quantum mechanics, setting the stage for unprecedented improvements in AI model performance. This research paves the way for a transformative future in AI, where quantum-inspired deep learning techniques could redefine the landscape of AI applications.
DFT-Guided Design and Synthesis of Nitrogen and Boron Dual-Doped Porous Carbon Catalyst Derived from Saccharina japonica for Oxygen Reduction Reaction
Authors: Zhang Junjie , Peng Xing , Wei Wuguo , Qiu Chao , Sun Xiaolin 
Published: June 2023

Abstract
The oxygen reduction reaction (ORR) is a critical process affecting the energy conversion efficiency of fuel cells. In this innovative study, six models were designed to showcase the superior ORR activity of nitrogen and boron dual-doped carbon (N, B dual-doped carbon) compared to N or B mono-doped carbon, as determined through density functional theory (DFT) calculations. Furthermore, a highly efficient N (4.63 at%), B (1.13 at%) dual-doped carbon ORR catalyst (S-850-1) was successfully synthesized from Saccharina japonica, which represents a rare achievement among biomass-derived carbon materials. Electrochemical analysis revealed a significant improvement in the half-wave potential (0.862 V) and limiting diffusion current density (-5.60 mA cm− 2) of S-850-1 compared to N mono-doped carbon (S-850: 0.839 V and − 5.24 mA cm− 2) in an alkaline solution. Additionally, S-850-1 exhibited enhanced durability and superior tolerance to methanol and CO, surpassing the performance of the commercial 20% Pt/C catalyst. Notably, S-850-1 was successfully incorporated into a Zn-air battery, generating an open circuit voltage of 1.40 V and effectively illuminating an LED light. The obtained electrochemical results were consistent with the DFT calculations, thereby confirming the high ORR activity of N, B dual-doped carbon in both theoretical and experimental domains. This groundbreaking research not only expands the range of biomass-derived ORR catalysts but also provides valuable insights into the design and synthesis of efficient and cost-effective catalysts derived from renewable sources.
TDF and TAF inhibit hepatocellular carcinoma cell migration, invasion via p7TP3
Authors: Zhao Jing , Zhou Li , Zhang Yang , Cheng Jun , Zeng Yilan , Li Xiuling 
Published: June 2023

Abstract
Tenofovir disoproxil fumarate (TDF) seems to prevent hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV). However, the mechanism is still little known. This study aimed to investigate the the roles and mechanisms of TDF, tenofovir alafenamide fumarate (TAF), and entecavir (ETV) on the malignant characteristics of liver cancer cells. Using the wound-healing assays, transwell assays, matrigel transwell assays, and cell counting kit-8 (CCK-8) assays, it was possible to identify that TDF/TAF, inhibited migration, invasion, and proliferation of HepG2 cells and Huh7 cells. To investigate the mechanisms, we performed TOP/FOP-Flash system, Western blot, and RT-qPCR assays of liver cancer cells cultured with TDF/TAF and found a lower activity of Wnt/β-catenin signaling pathway compared with control cells. Finally, Hepatitis C virus p7 trans-regulated protein 3 (P7TP3), a tumor suppressor in HCC, was significantly increased in HepG2 cells and Huh7 cells that treated with TDF/TAF. However, entecavir (ETV)-treated liver cancer cells showed no significant difference in the malignant characteristics of HCC cells, activity of Wnt/β-catenin signaling pathway, and expression of p7TP3, compared with the control groups. To conclude, TDF/TAF maybe novel promising therapeutic strategy for HCC via Wnt/β-catenin signaling pathway, by up-regulating expression of the tumor suppressor, P7TP3.
Metagenomic profile of the taxonomic classification and functional diversity of soil bacterial population in the Veerakkal forest area, Western Ghats, India
Authors: Ramya Eswaran Kasthuri , Sharmila Somasundaram , Sarathbabu Subbarayan , Kumar Nachimuthu Senthil , Sajitha Bhoopathy , Karthik Selvaraj , Mownika Sakthivel 
Published: June 2023

Abstract
The study aimed to assess the whole bacterial population and functions of two different soils (PP and TA) through the next-generation sequencing (NGS) method in the Veerakkal forest area, Western Ghats, Tamil Nadu, India. The forest soil is slightly acidic in nature and also rich in soil organic matter. The bacterial sequence reads under soil is classified taxonomically into 14 bacterial and 2 archaeal phyla, 45 classes, 88 orders, 119 families, and 146 genera. Acidobacteria is found to be the most populated phyla accounting for 25% population in PP soil, whereas 35% of Proteobacteria is the most abundant phyla in TA soil. The PP soil has more OTUs and a higher Shannon index than the TA soil which indicates a diversity gradient of soil bacteria restricted in the study site. Using PICRUSt functional analysis, the KEGG function of level I is discovered that Metabolism has the largest amount of genomic sequences involved (PP – 56%, TA – 54%), and KEGG level II identifies a greater proportion of the community involved in Amino acid metabolism (PP and TA – 14%) followed by Carbohydrate metabolism (PP and TA – 11%), Membrane transport (PP and TA – 10%) and Energy metabolism (PP and TA – 8%), all of these are most frequent categories in the study site. The presence of carbohydrate metabolism at above 11% has confirmed the study samples for bacterial potential towards cellulolytic activity in the soil environment. Further, this study suggests that the revealed bacterial isolates have the potential in recycling agro by-products and their utilization in industrial applications.
Mapping of Health Technology Assessment in China: A Comparative Study Between 2016 and 2021
Authors: Liu Shimeng , Xia Yu , Yang Yi , Ming Jian , Sun Hui , Wei Yan , Chen Yingyao 
Published: June 2023

Abstract
Background
Health technology assessment (HTA) in China has recently expanded from pure academic research to include policy or decision-oriented practice, especially after the use of HTA evidence to update the National Reimbursement Drug List for the first time in 2017. This study aimed to identify the progress and challenges of HTA development from 2016 to 2021 and to inform policies and decisions to promote further development of HTA in China.
Methods
We conducted a cross-sectional web-based survey to policy maker, researcher and industry-provider in China in 2016 and 2021 respectively. The mapping of HTA instrument was used to reflect the HTA development from eight domains: institutionalization, identification, priority setting, assessment, appraisal, reporting, dissemination of findings and conclusions, implementation in policy and practice. To reduce the influence of confounders and to compare the mapping outcomes between 2016 and 2021 group, we performed a 1:1 propensity score matching methodology in this study. Univariate analysis was performed to compare the differences in these two groups. We also compared the overall results with that of a mapping study that included ten countries.
Results
A total of 212 and 255 respondents completed the survey in 2016 and 2021 respectively. After propensity score matching methodology, 183 cases from the 2016 group and 2021 group were matched. Overall, the mean score of 2021 in most of the domains was higher than 2016 in China (P < 0.05), such as the level of HTA institutionalization, appraisal and dissemination strategy, except for assessment. Although China scored significantly lower among the three developed countries, the overall HTA development score was comparable among the ten countries.
Conclusions
Our study suggested the level of HTA development in China has achieved significant progress from 2016 to 2021. Prior to HTA activities, more efforts should be made to the assessment process, for example, describing a clearer goal and scope of HTA, adapting standard HTA methodologies for assessing the performance of systematic review or meta-analysis, providing a clear description of the safety and clinical effectiveness, cost and cost-effectiveness of the technology in their assessments, et al, thus improving the development of HTA in China.
Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Authors: Huang Jian , Wang Zhengji , Chen Zihe , Huang Chunxin , Wang Ying , Li Xing , Lv Weiyang , Qi Guiqiang , Liu Huilin 
Published: June 2023

Abstract
The authors have requested that this preprint be removed from Research Square.
Nonequilibrium effects in ballistic point contacts Ta − Cu and 2H − NbSe2 − Cu. Two-gap superconductivity in 2H − NbSe2
Authors: Bobrov Nikolai L. 
Published: June 2023

Abstract
The Ta−Cu and NbSe2−Cu heterocontacts have been studied. For T a−Cu contacts the theoretical estimation of the value of δ-functional barrier at the boundary arising due to the mismatch of Fermi parameters of the contacting metals was carried out and a good agreement between the calculation and experiment was obtained. An expression for the estimation of the diameter of the heterocontact on either side of the boundary is obtained. The magnitude of the jump-like decrease in the excess current (and the superconducting gap) due to the phase transition of the superconductor region near the point contact into a spatially inhomogeneous state when the critical concentration of nonequilibrium quasiparticles is reached has been determined. Obtained dependence of the additive differential resistance on the offsets at the contact arising after the phase transition, due to the excess charge of quasiparticles and the associated reverse current (or additive voltage). In 2H − NbSe2 there is a two-zone superconductivity character with ∼8 times different energy gap values. Under the influence of current injection of nonequilibrium quasiparticles there is a sequential phase transition of the layers adjacent to the pint contact into a spatially inhomogeneous state with a suppressed gap, which is accompanied by a step change in the slope of the I −V curve with a discrete increase in the differential resistance.
Optimization of electrode preparation conditions by response surface methodology for improved formic acid electrooxidation on Pd/MWCNT/GCE
Authors: Ulas Berdan 
Published: June 2023

Abstract
This work examines the formic acid electrooxidation (FAEO) capabilities of Pd catalysts supported by multiwall carbon nanotubes (MWCNTs) that were synthesized at varying weight percentages. Advanced surface analysis techniques namely X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy with X-ray energy dispersive (SEM-EDX), and elemental mapping are used to evaluate the Pd/MWCNT. To achieve the highest specific activity for FAEO on Pd/MWCNT, electrode preparation parameters namely catalyst slurry amount (Vs), ultrasonication duration of catalyst slurry (tu), and electrode drying time (td) were optimized by response surface methodology central composite design (RSM-CCD). Measurements made using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry (CA) are used to determine the specific activity and stability for FAEO. The optimum values for the Vs, td, and tu were determined as 1.84 µl, 45 min, and 37.05 min while under these optimum conditions, the specific activity for FAEO on Pd/MWCNT was 2.67 mA cm-2 with a deviation of 6.83%. By optimizing the electrode preparation conditions, a conventional Pd/MWCNT catalyst showed higher performance than many bimetallic catalysts. Optimization of electrode preparation parameters is as important as catalyst design and is an inexpensive and facile method to improve electrocatalytic performance.
Application of soft computing in predicting the compressive Strength of Self-Compacted Concrete Containing Recyclable Aggregate
Authors: Albostami Asad S. , Al-Hamd Rwayda Kh. S. , Alzabeebee Saif , Minto Andrew , Keawsawasvong Suraparb 
Published: June 2023

Abstract
Self-compacting concrete (SCC) is a type of concrete that is known for its environmental benefits and improved workability. In this study, data-driven approaches were used to anticipate the compressive strength (CS) of self-compacting concrete (SCC) containing recycled plastic aggregates (RPA). A database of 400 experimental data sets was used to assess the capabilities of Multi-Objective Genetic Algorithm Evolutionary Polynomial Regression (MOGA-EPR) and Gene Expression Programming (GEP). The results of the analysis indicated that the proposed equations provided more accurate CS predictions than traditional approaches such as the Linear Regression model (LRM). The proposed equations achieved lower mean absolute error (MAE) and root mean square error (RMSE) values, a mean close to the optimum value (1.0), and a higher coefficient of determination (R2) than the LRM. As such, the proposed approaches can be utilized to obtain more reliable design calculations and better predictions of CS in SCC incorporating RPA.
Local ecological learning: creating place-based knowledge through collaborative wildlife research on private lands
Authors: Taylor Matthew , Davison Aidan , Harwood Andrew 
Published: June 2023

Abstract

Wildlife on private land is under threat from anthropogenic drivers including climate change, invasive species, and habitat loss. Effective management of private lands for wildlife conservation requires locally relevant knowledge about wildlife populations, habitat condition, threatening ecological processes, and social drivers of and barriers to conservation. Collaborative socio-ecological research can inform wildlife management by integrating the local ecological and social knowledge of private landholders with the scientific and applied knowledge of researchers and practitioners. In privately owned landscapes, landholders are an often-overlooked source of local ecological knowledge, which develops and changes through continuous interaction and engagement with their environment and community. Here we report on a transdisciplinary socio-ecological research collaboration called WildTracker involving 160 landholders in Tasmania, Australia. This wildlife-focused citizen science project generated and integrated local ecological and social knowledge in the research process. The project gathered quantitative and qualitative data on wildlife ecology, land management practices, and landholder learning via wildlife cameras, sound recorders, workshops, questionnaires, and semi-structured interviews. Through this on-going collaboration, landholders, researchers, and conservation practitioners established relationships based on mutual learning, gathering, and sharing knowledge and insights about wildlife conservation. Our project highlights how local ecological knowledge develops and changes continuously through processes of enquiry and interaction with other knowledge holders including researchers and conservation practitioners. Collaborative enquiry involving landholders and researchers can produce rich cultural and ecological insights derived from the direct experience and observation of landholders, complementing quantitative assessments of wildlife populations and habitat condition.
Assessing conservation status of calcareous grassland in two French military training areas in Natura 2000 context
Authors: Pascaline Caudal , Sébastien Gallet 
Published: June 2023

Abstract

Calcareous grasslands are habitats of high conservation value. These rich habitats are declining notably due to agriculture and habitat fragmentation. In France, calcareous grasslands may be found on Military Training Areas (MTA), which protect them from intensive agriculture and urban development. By analysing their floristic structure and composition, the aim of this publication is to determine the conservation status of grassland on two French MTA, following a militarisation gradient. Vegetation characteristics appeared different according to the level of military activities. Military activities and their related management, favour rich and diversified grasslands in the good conservation state. They also allow the creation of a mosaic of habitats within the grasslands with the presence of overgrown areas. Thus, MTAs appeared to present good potential for preserving the remaining calcareous grassland in France.
High-Dimensional Sparse Single-Index Regression via Hilbert-Schmidt Independence Criterion
Authors: Chen Xin , Deng Chang , He Shuaida , Wu Runxiong , Zhang Jia 
Published: June 2023

Abstract
Hilbert-Schmidt Independence Criterion (HSIC) has recently been introduced to the field of single-index models to estimate the directions. Compared with other well-established methods, the HSIC based method requires relatively weak conditions. However, its performance has not yet been studied in the prevalent high-dimensional scenarios, where the number of covariates can be much larger than the sample size. In this article, based on HSIC, we propose to estimate the possibly sparse directions in the high-dimensional single-index models through a parameter reformulation. Our approach estimates the subspace of the direction directly and performs variable selection simultaneously. Due to the non-convexity of the objective function and the complexity of the constraints, a majorize-minimize algorithm together with the linearized alternating direction method of multipliers is developed to solve the optimization problem. Since it does not involve the inverse of the covariance matrix, the algorithm can naturally handle large $p$ small $n$ scenarios. Through extensive simulation studies and a real data analysis, we show that our proposal is efficient and effective in the high-dimensional settings. The $\verb|Matlab|$ codes for this method are available online.
Dependence of eigenvalues for higher odd-order differential operator with transmission conditions
Authors: Ji Antong , Xu Meizhen 
Published: June 2023

Abstract
In this paper, we consider the dependence of eigenvalues on the parameter for higher odd-order differential operator with three types of boundary conditions and corresponding transmission conditions. By defining an appropriate Hilbert space and its inner product, we prove that the eigenvalues of the operators associated with the problem are real and discrete, and give the resolvent operators related to the differential operators. In addition, we show that the eigenvalues are not only continuously but also smoothly dependent on the parameters of the problem, and give the corresponding differential expressions. In particular, giving the Frechet derivatives of the eigenvalues concerning the coefficient functions q0, q1, · · · , qn and the derivatives of the eigenvalues with respect to the left and right sides of the inner discontinuity point c.