bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features and prognostic significance of DNMT3A, FLT3, and NPM1 mutations in de novo acute myeloid leukemia patients
Authors: Chen Meiyu , Zeng Zhao , Li Xuewei , Qin Wei , Cai Xiaohui , Chen Suning , Lu Xuzhang 
Published: July 2023

AbstractObjectiveDifferent co‐mutation patterns are associated with varied clinical manifestations and prognosis. The purpose of this research was to explore the clinical characteristics and prognosis of individuals with AML who had DNMT3A, FLT3, and NPM1 mutations.Materials and MethodsA total of 259 newly diagnosed AML patients were investigated in this study, including 148 AMLFLT3mutDNMT3Awt, 48 AMLFLT3wtDNMT3Amut, and 63 AMLFLT3mutDNMT3Amut patients. Mutations were detected by targeted next‐generation sequencing and Sanger sequencing. In addition, we utilized the publicly available data to analyze the expression profiles of AML.ResultsCorrelation analysis showed NPM1 mutations were positively associated with FLT3‐ITD and DNMT3A, but negatively with CEBPA and RUNX1 mutations. In the presence of both DNMT3A and FLT3 mutations, patients were associated with typical clinical manifestations such as heavy disease burden and old age. Patients with both FLT3 and DNMT3A mutations had lower complete remission rates and poorer clinical outcomes than those with FLT3 or DNMT3A mutation alone. Univariate analysis showed that age, response to treatment, DNMT3A R882 mutation, NPM1 mutation, and consolidation treatment options were associated with OS. According to multivariate analysis, only consolidation treatment options could be considered as an independent prognostic factor. In addition, the percentage of AMLFLT3mutDNMT3AmutNPM1mut patients in our study was about 5.9%. Interestingly, the expression profile of this subgroup was significantly related to HOX family and histone H1 family, and enriched pathways associated with transcriptional misregulation.ConclusionWe comprehensively evaluated the clinical and genetic characteristics, and expression profiles of AML patients with common mutations, and found that AML patients with triple mutations might be a distinct AML subtype, which should be redefined.
Impact of wound complications in obese versus non‐obese patients undergoing total hip arthroplasty: A meta‐analysis
Authors: Yang Yufei , Zhao Zhenqun , Wang Yong , Gao Yuhui , Sun Hongyan , Liu Wanlin 
Published: July 2023

AbstractThis meta‐analysis examined the post‐operative wound effect of both obese and non‐obese in total hip arthroplasty (THA) patients. To gather as complete an overview as possible, the researchers took advantage of 4 databases—PubMed, Embase, Cochrane Library and Web of Science—to conduct a critical assessment. Following the development of inclusion and exclusion criteria, the researchers evaluated the quality of each document. A total of 9 related trials were conducted to determine the 95% CI (CI) and OR using a fixed‐effect model. The final meta‐analyses were conducted with RevMan 5.3. Our findings indicate that there is no statistically significant benefit in terms of post‐operative wound complications among obese and non‐obese patients. Obese subjects had a significantly higher risk of injury than those without obesity (OR, 1.43; 95% CI, 1.04, 1.95, p = 0.03); obesity was also associated with a significantly higher risk of operative site infection than in non‐obese subjects (OR, 1.96; 95% CI, 1.76, 2.18, p < 0.0001); and after surgery, there was also a significant increase in the risk of post‐operative wound infections among obese subjects than in non‐obese subjects (OR, 1.57; 95% CI, 1.34, 1.84, p < 0.0001). However, due to the small size of the cohort study in this meta‐study, caution is required in the analysis. More randomized, controlled studies will be needed to validate these results.
Immediate loading of dental implants in edentulous mandibles using Locator attachments or Dolder bars: A 9‐year prospective randomized clinical study
Authors: Kostunov Jana , Menzel Regina , Bermejo Justo Lorenzo , Rammelsberg Peter , Giannakopoulos Nikolaos Nikitas , Kappel Stefanie 
Published: July 2023

AbstractAimTo evaluate the long‐term survival, incidence of prosthetic/technical and biological complications and the oral‐health‐related quality of life in patients with an edentulous mandible who were fitted with overdentures on two immediately loaded implants in the symphyseal area.Materials and MethodsForty‐six patients with edentulous mandibles received two immediately loaded implant‐retained dentures with either two Locator attachments or egg‐shaped bar attachments. Implant outcomes were recorded after a period of observation of 9 years and included prosthetic complications, modified gingiva index (mGI), modified plaque index (mPI), oral health impact profile (OHIP‐G) and radiographic estimation of bone loss.ResultsIn 2020/2021, 27 patients with 54 implants were still available for follow‐up. In total, nine implants in six patients were lost. Survival was 89.1% in the bar group and 91.3% in the Locator group. Implant success was 84.6% in the Locator group and 76.9% in the bar group. The mPI values were significantly higher in the bar group than in the Locator group, whereas no difference was seen in the mGI values. During the observation period, 152 prosthetic complications occurred, but the OHIP‐G score did not differ significantly.ConclusionsThere was no difference in implant survival between Locator or joint bar attachments over a 9‐year observation period. Joint bar attachments were associated with slightly more complications, while patients in the Locator group were able to maintain better oral hygiene. The study was registered in the German Register of Clinical (Trials DRKS00004245).
Recent advances with cold plasma technology for millet processing: A brief review
Authors: Balendran Susindra Devi , Kalaivendan Ranjitha Gracy T. , Theagarajan Radhika 
Published: July 2023

AbstractAs a grain with high nutritional content and tolerance to extreme weather, millet has a potential food business. However, the processing is necessary to enhance the physical and nutritional quality of millet. Food products with minimal processing, improved sensorial and natural flavors, with no added chemicals to preserve them are in greater demand among customers. High‐quality product produced using green alternative processing techniques significantly evolved in the last two decades. Moreover, recent years see potential study of cold plasma technology in the food industry for increased functional attributes and energy efficiency. This review has been framed to describe the impact of cold plasma on the quality attributes of millet and millet products exploring cold plasma research on millet products, focusing on nutrition, anti‐nutrient reduction, structural, physicochemical, digestive, hydration, and functional properties. Furthermore, this work pursues to improve interventions by identifying the knowledge gaps in the processing of millet using cold plasma.Practical ApplicationsThe shelf life of the millet products is extended as a result of the plasma treatment, through the reduction in the moisture content. During the early stages of storage, millet flour is affected by rancidity, which is positively treated by plasma processing. The water absorption and swelling capacity of the treated millet sample have increased along with a rise in solubility. Therefore, the hydration and pasting abilities of millet improved, making it possible to utilize it in complementary food formulations as well as for the development of viscous foods.
An examination of power in a triadic model of parent–child–pediatrician relationships related to early childhood gender development
Authors: Lenne Eline , Sun Christina J. , Klawetter Susanne 
Published: July 2023

AbstractIn this paper, the authors introduce the Triadic Model of Pediatric Care, an innovative conceptual framework for pediatric practice with transgender and gender diverse children. The Triadic Model of Pediatric Care consists of three experts—pediatricians, primary caregiver(s), and children—who each possess unique insights, knowledge, and decision‐making power. This model guides pediatricians to provide gender‐affirming care that acknowledges children as experts of their own experience and worthy of bodily autonomy, while also working to ensure primary caregiver(s) have the information and support necessary to provide a safe and nurturing developmental environment for their child. The authors provide a recommendation for how the Triadic Model of Pediatric Care might be applied in a pediatric healthcare setting and conclude with a summary of the model's implications, limitations, and future directions.
Palaeobiological inferences of “rauisuchians” Fasolasuchus tenax (Los Colorados Fm., Argentina) and Prestosuchus chiniquensis (Santa Maria Super sequence, Brazil) from the Middle–Upper Triassic of South America based on microstructural analyses
Authors: Ponce Denis A. , Scheyer Torsten M. , Cerda Ignacio A. , Desojo Julia B. 
Published: July 2023

Abstract“Rauisuchia” is a non‐monophyletic group of quadrupedal and carnivorous pseudosuchians that inhabited the entire world during the Middle–Upper Triassic period (Anisian/Ladinian–Rhaetian). In South America, “rauisuchians” reached the largest sizes among continental carnivores. Despite their important ecological role, some aspects of their palaeobiology have been poorly examined. Here, we study appendicular bones, dorsal ribs and osteoderms of two genera, the Argentinean Fasolasuchus tenax (PVL 3850, holotype) and the Brazilian Prestosuchus chiniquensis (SNSB‐BSPG AS XXV) respectively. The femur of F. tenax is formed by laminar fibrolamellar bone, which is composed of non‐fully monorefringent woven‐fibred matrix and primary osteons; the dorsal rib has a Haversian bone composition with an external fundamental system recorded and the osteoderm is formed by well‐organised parallel‐fibred bone. The femur, humerus and fibula of P. chiniquensis are mostly composed of strongly arranged parallel‐fibred bone and a laminar vascularisation. The minimal ages obtained correspond to 9 years for F. tenax (based on the maximum number of growth marks in the osteoderm) and 4 years for P. chiniquensis (obtained from the highest count of growth marks in the femur and in the humerus). F. tenax attained somatic and skeletal maturity, while P. chiniquensis was near to reaching skeletal and sexual maturity, but it was somatically immature. The overall rapid growth rate and the high and uniform vascularisation seems to imply that these features are common in most of “rauisuchians”, except in P. chiniquensis.
The GABA system, a new target for medications against cognitive impairment—Associated with neuroactive steroids
Authors: Bäckström Torbjörn , Turkmen Sahruh , Das Roshni , Doverskog Magnus , Blackburn Thomas P. 
Published: July 2023

AbstractThe prevalence of cognitive dysfunction, dementia, and neurodegenerative disorders such as Alzheimer's disease (AD) is increasing in parallel with an aging population. Distinct types of chronic stress are thought to be instrumental in the development of cognitive impairment in central nervous system (CNS) disorders where cognitive impairment is a major unmet medical need. Increased GABAergic tone is a mediator of stress effects but is also a result of other factors in CNS disorders. Positive GABA‐A receptor modulating stress and sex steroids (steroid‐PAMs) such as allopregnanolone (ALLO) and medroxyprogesterone acetate can provoke impaired cognition. As such, ALLO impairs memory and learning in both animals and humans. In transgenic AD animal studies, continuous exposure to ALLO at physiological levels impairs cognition and increases degenerative AD pathology, whereas intermittent ALLO injections enhance cognition, indicating pleiotropic functions of ALLO. We have shown that GABA‐A receptor modulating steroid antagonists (GAMSAs) can block the acute negative cognitive impairment of ALLO on memory in animal studies and in patients with cognitive impairment due to hepatic encephalopathy. Here we describe disorders affected by steroid‐PAMs and opportunities to treat these adverse effects of steroid‐PAMs with novel GAMSAs.
Non‐executive Employee Ownership and Target Selection in High‐Tech Mergers and Acquisitions
Authors: Shi Wei , Li Jiangyan , McNamara Gerry 
Published: July 2023

AbstractThe quest to build and expand a firm's human capital is a key driver for mergers and acquisitions (M&As), but acquiring firms often face the threat of losing their targets' key employees in the post‐M&A period. This is particularly true for high‐tech M&As, as human capital is especially important in high‐tech industries. Because non‐executive employee ownership can incentivize employees to invest in firm‐specific human capital, reducing the likelihood that employees will leave, we argue that when screening for potential M&A targets, acquiring firms are more likely to target companies with higher levels of employee ownership. We also argue that the screening role of employee ownership in M&A target selection will be stronger when targets have higher R&D intensity but weaker when targets treat their employees better. Using a sample of 26,137 firm‐year observations, we find support for our arguments. Findings from this study contribute to M&A research by highlighting the importance of non‐executive employee ownership as a screen for human capital retention in M&A target selection.
Phylogenetic and taxonomic relationships between morphotypes related to Elymus caninus (Poaceae) based on sequence of a nuclear gene GBSS1 (waxy) and sexual hybridization
Authors: Agafonov Alexander V. , Shabanova Elena V. , Emtseva Maria V. , Asbaganov Sergey V. , Morozov Igor V. , Bondar Alexander A. , Dorogina Olga V. 
Published: July 2023

AbstractWe represent a comparative analysis of GBSS1 gene fragment sequences for a number of species related to Elymus caninus: Elymus prokudinii, Elymus viridiglumis, Elymus goloskokovii, as well as a number of morphologically deviating biotypes, inhabiting Russia and Kazakhstan. Microevolutionary relationships between species were assessed from dendrograms derived from sequences of exons and introns. In all taxa, the St subgenome was represented by St2 variants, rather typical of the North American ancestral line of Pseudoroegneria spicata than of the Asian line descending from Pseudoroegneria strigosa. All putative relatives of E. caninus had H1 subgenome variants linked around the Asian diploid carrier of the H genome from Hordeum jubatum and were divided into two subclades. One of them (H1‐1) contained most of the closely related E. caninus clones, including Elymus uralensis. Another subclade (H1‐2) consisted of five variants phylogenetically related to Elymus mutabilis. We have also studied reproductive relationships between species E. goloskokovii, E. prokudinii, and E. viridiglumis and the degree of their integration into the E. caninus complex. Biotypes included in sexual hybridization formed a single recombination gene pool, within which slight differences in reproductive compatibility were observed. A comprehensive study of microevolutionary differentiation of taxa showed the expediency of taxonomic revision. The species mentioned should probably be relegated to the infraspecific rank within E. caninus s. l.
Effects of tributyrin on the growth performance, survival, tolerance to hypoxic stress, and nutrient digestibility of Pacific white shrimp, Litopenaeus vannamei, fed different levels of soybean meal
Authors: Rairat Tirawat , Phansawat Putsucha , Keetanon Arunothai , Kachapol Parattagorn , Kumphaphat Sunisa , Kitsanayanyong Lalitphan , Chou Chi‐Chung , Chuchird Niti 
Published: July 2023

AbstractThe study aimed to evaluate the effect of tributyrin on the growth performance, survival, hypoxia tolerance, and nutrient digestibility of Pacific white shrimp fed 25% and 50% soybean meal (SBM) diets. Six experimental diets were formulated: (1) 25% SBM without tributyrin; (2) 25% SBM with 0.05% tributyrin; (3) 25% SBM with 0.1% tributyrin; (4) 50% SBM without tributyrin; (5) 50% SBM with 0.05% tributyrin; and (6) 50% SBM with 0.1% tributyrin. The shrimp were fed the experimental diets daily for 10 weeks. Tributyrin supplementation at 0.1% diet significantly improved the weight gain of shrimp that fed 25% SBM but not the other groups. Nevertheless, shrimp that fed tributyrin had significant improvement in survival rate at both SBM levels. Significant reductions in Vibrio spp. counts in the hepatopancreas and intestine were also evident in all tributyrin‐fed groups. In addition, 0.1% tributyrin in both SBM levels significantly enhanced the shrimp tolerance to hypoxia. Lastly, the digestibilities were generally unaffected by the tributyrin except only for the lipid digestibility of the 0.1% tributyrin in 25% SBM group, which showed a significant increase. Overall, tributyrin was proven beneficial for the shrimp's health, especially for those fed diet with a moderate level of SBM (25%).
Species distribution modeling of deep‐diving cetaceans
Authors: Fiedler Paul C. , Becker Elizabeth A. , Forney Karin A. , Barlow Jay , Moore Jeff E. 
Published: July 2023

AbstractSpecies distribution models (SDMs) have been developed and extensively validated for diverse cetaceans within the California Current Ecosystem off the West Coast of the United States. These studies have recognized the challenges associated with developing robust models for deep‐diving cetaceans—sperm whales and beaked whales—thus limiting the accuracy of predictions for management and ecological understanding. In this study, we explore whether additional biologically relevant predictor variables can improve models for deep‐divers. These variables are related to the oxygen minimum layer and phytoplankton and micronekton biomass and could influence prey availability for cetacean top predators. We found that the addition of these variables improved the performance of SDMs for sperm whales, as well as for some more common baleen whale and dolphin species, but that the accuracy of deep‐diver models was nevertheless poor. The sightings data sets for deep‐diving cetaceans have small sample sizes compared to other cetaceans, and sightings are distributed nearly randomly across the study area and model domain. These factors hinder the development of useful environmentally driven models of spatial distribution.
Evaluation of the CHROMagar Candida Plus medium for presumptive identification of yeasts and MALDI‐TOF MS identification
Authors: Taverna Constanza Giselle , Vivot Matías Ezequiel , Arias Bárbara Abigail , Irazu Lucia , Canteros Cristina Elena 
Published: July 2023

AbstractRapid and accurate yeasts species identification in clinical laboratories is important for appropriate and timely antifungal treatment. We evaluate the performance of the new medium CHROMagar™ Candida Plus for presumptive identification of yeasts species and MALDI‐TOF identification. We identify 303 strains belonging to 60 clinically relevant yeasts species by using the new medium. Presumptive identification was correct at the Candida albicans complex, Candida tropicalis and Pichia kudriavzevii (Candida krusei) species. However, although this medium was able to identify all Candida auris and Candida glabrata strains, other species were misidentified as C. auris or C. glabrata. A total of 215 strains were identified by using MALDI‐TOF and evaluated two incubation temperatures (30°C and 37°C) and two incubation times (24 h and 72 h). Most strains (94%; 202/215) were correctly identified at the species (n:190) or complex level (n:12) at both temperatures and incubation times. However, we observed that the time of incubation (24 h vs. 72 h) affects the score values when yeasts are incubated at 37°C, but does not affect score values when yeasts are incubated at 30°C. In conclusion, the new medium has a good performance in the presumptive identification of the C. albicans complex, C. tropicalis and P. kudriavzevii (C. krusei). In addition, this medium is useful for the screening of C. auris and C. glabrata isolates, but identification should be confirmed by other more specific techniques, like MALDI‐TOF.
The role of social media in facilitating minority mobilisation: The Russian‐language pro‐war movement in Germany amid the invasion of Ukraine
Authors: Sablina Liliia 
Published: July 2023

AbstractThis article examines the mobilisation of minority groups along ethnic and national lines through social media, an area that has not been fully explored. The study analyses the case of Russian‐speaking minority members who were mobilised in support of the Russian invasion of Ukraine in 2022 via the messaging app Telegram. By taking a bottom‐up perspective, the article reconstructs the pathways of the actors in these mobilisation processes and draws upon diverse literature in digital nationalism, social movements and media studies. The study suggests that social media facilitates minority mobilisation through three primary functions: It allows for the reproduction of ethnicised and racialised boundaries and homogenisation within ethnicised echo chambers and provides a ‘window of opportunity’ for micro, meso and macro levels of actor engagement in facilitating offline mobilisation. Overall, this article provides a theoretical foundation for understanding how social media enables and enhances minority mobilisation and introduces novel empirical data on the emerging pro‐war movement prevalent on Telegram and in offline networks of the Russian‐speaking minority in Germany. The study contributes to the developing field of user‐generated nationalism and highlights the need for more bottom‐up research on emerging patterns of online ethnicised mobilisation.