bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between reported post-COVID-19 symptoms and subjective well-being, Israel, July 2021 – April 2022
Authors: Gorelik Yanay , Dror Amiel , Zayyad Hiba , Wertheim Ofir , Abu Jabal Kamal , Nazzal Saleh , Otiku Paul , Elsinga Jelte , Glikman Daniel , Edelstein Michael 
Published: January 2023

Abstract
The impact of individual symptoms reported post-COVID-19 on subjective well-being (SWB) is unknown. We described associations between SWB and selected reported symptoms following SARS-CoV-2 infection. We analysed reported symptoms and subjective well being from 2295 participants (of which 576 reporting previous infection) in an ongoing longitudinal cohort study taking place in Israel. We estimated changes in SWB associated with reported selected symptoms at three follow-up time points (3–6, 6–12 and 12–18 months post infection) among participants reporting previous SARS-CoV-2 infection, adjusted for key demographic variables, using linear regression. Our results suggest that the biggest and most sustained changes in SWB stems from non-specific symptoms (fatigue −7.7 percentage points (pp), confusion/ lack of concentration −10.7 pp, and sleep disorders −11.5pp, P < 0.005), whereas the effect of system-specific symptoms, such as musculoskeletal symptoms (weakness in muscles and muscle pain) on SWB, are less profound and more transient. Taking a similar approach for other symptoms and following individuals over time to describe trends in SWB changes attributable to specific symptoms will help understand the post-acute phase of COVID-19 and how it should be defined and better managed. Post-acute COVID19 symptoms were associated with a significant decrease in subjective well being up to 18 months after initial infection
Captured with malicious intent? The opportunities and limits of debt imprisonment in late medieval Bruges
Authors: Fieremans Niels 
Published: January 2023

AbstractDebt imprisonment was one of the tools a creditor had to enforce a debt. When creditors believed that their debtors were defaulting, they could imprison debtors to ensure they would not disappear and debts would be settled. As a practice, debt imprisonment was never fundamentally challenged in the Middle Ages though the way it was executed did come under scrutiny. In the city of Bruges, the city magistrate regulated the practice. As debt imprisonment was an essential part of the commercial framework in Bruges, the city tried to avoid princely interference. However, merchants could also complain to princely courts about their imprisonment. If the city hesitated to address unjust practices in the existing framework, it risked losing these cases to princely courts. As princely institutions increased their control over debt imprisonment, the city government kept the mechanism of debt imprisonment while, for example, Antwerp sought alternative tools for creditors. The adaptations that did happen in Bruges were not the result of the requests of merchants, but a means of rather safeguarding its own jurisdictions from princely courts.
Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants
Authors: Nayema Zannatun , Sato Takehiro , Kannon Takayuki , Tsujiguchi Hiromasa , Hosomichi Kazuyoshi , Nakamura Hiroyuki , Tajima Atsushi 
Published: January 2023

AbstractAmylase activity and levels in humans are heritable quantitative traits. Although many studies exist on the effects of copy-number variants (CNVs) in amylase genes (AMY) on human phenotypes, such as body mass index (BMI), the genetic factors controlling interindividual variation in amylase levels remain poorly understood. Here, we conducted a genome-wide association study (GWAS) of serum amylase levels (SAL) in 814 Japanese individuals to identify associated single-nucleotide variants (SNVs), after adjusting for non-genetic factors. Diploid copy numbers (CN) of AMY (AMY1, AMY2A, and AMY2B) were measured using droplet digital PCR to examine the association between each diploid CN and SAL. We further assessed the relative contribution of the GWAS-lead SNV and AMY CNVs to SAL. GWAS identified 14 significant SNVs (p < 5 × 10−8) within a linkage disequilibrium block near the AMY cluster on chromosome 1. The association analyses of AMY CNVs and SAL showed a significant association between AMY1 diploid CN and SAL (p = 1.89 × 10−19), while no significant association with SAL was found for AMY2A CN (p = 0.54) or AMY2B CN (p = 0.15). In a joint association analysis with SAL using the GWAS-lead SNV and AMY1 diploid CN, AMY1 CN remained significant (p = 5.4 ×10−13), while the association of the lead SNV was marginal (p = 0.08). We also found no association between AMY1 diploid CN and BMI (p = 0.14). Our results indicate that AMY1 CNV is the major genetic factor for Japanese SAL, with no significant association with BMI.
Predictors of pesticide levels in carpet dust collected from child care centers in Northern California, USA
Authors: Hazard Kimberly , Alkon Abbey , Gunier Robert B. , Castorina Rosemary , Camann David , Quarderer Shraddha , Bradman Asa 
Published: January 2023

Abstract
Background
Young children may be exposed to pesticides in child care centers, but little is known about determinants of pesticide contamination in these environments.

Objective
Characterize pesticide contamination in early care and education (ECE) centers and identify predictors of pesticide concentrations and loading in dust collected from classroom carpets.

Methods
Carpet dust samples were collected from 51 licensed child care centers in Northern California and analyzed for 14 structural and agricultural pesticides. Program characteristics were collected through administration of director interviews and observational surveys, including an integrated pest management (IPM) inspection. Pesticide use information for the prior year was obtained from the California Department of Pesticide Regulation to characterize structural applications and nearby agricultural pesticide use.

Results
The most frequently detected pesticides were cis-permethrin (98%), trans-permethrin (98%), bifenthrin (94%), fipronil (94%), and chlorpyrifos (88%). Higher bifenthrin levels were correlated with agricultural applications within 3 kilometers, and higher fipronil levels were correlated with professional pesticide applications in the prior year. In multivariable models, higher IPM Checklist scores were associated with lower loading of chlorpyrifos and permethrin. Placement of the sampled area carpet was also a predictor of chlorpyrifos loading. The strongest predictor of higher pesticide loading for the most frequently detected pesticides was location in California’s San Joaquin Valley.

Significance
Our findings contribute to the growing understanding that pesticides are ubiquitous in children’s environments. Pesticide levels in carpet dust were associated with some factors that ECE directors may have control over, such as IPM practices, and others that are beyond their control, such as geographic location. IPM is an important tool that has the potential to reduce pesticide exposures in ECE environments, even for pesticides no longer in use.

Impact
One million children in California under six years old attend child care programs where they may spend up to 40 h per week. Children are uniquely vulnerable to environmental contaminants; however early care settings are under researched in environmental health studies. Little is known about predictors of pesticide levels found in environmental samples from child care facilities. This study aims to identify behavioral and environmental determinants of pesticide contamination in California child care centers. Findings can empower child care providers and consumers and inform decision makers to reduce children’s exposures to pesticides and promote lifelong health.
Real-world use of blinatumomab in adult patients with B-cell acute lymphoblastic leukemia in clinical practice: results from the NEUF study
Authors: Boissel Nicolas , Chiaretti Sabina , Papayannidis Cristina , Ribera Josep-Maria , Bassan Renato , Sokolov Andrey N. , Alam Naufil , Brescianini Alessandra , Pezzani Isabella , Kreuzbauer Georg , Zugmaier Gerhard , Foà Robin , Rambaldi Alessandro 
Published: January 2023

AbstractThis retrospective observational study (NEUF) included adult patients with B-cell acute lymphoblastic leukemia (B-cell ALL) who had received blinatumomab for the treatment of minimal residual disease-positive (MRD+) or relapsed/refractory (R/R) B-cell ALL via an expanded access program (EAP). Patients were eligible if blinatumomab was initiated via the EAP between January 2014 and June 2017. Patients were followed from blinatumomab initiation until death, entry into a clinical trial, the end of follow-up, or the end of the study period (December 31, 2017), whichever occurred first. Of the 249 adult patients included, 109 were MRD+ (83 Philadelphia chromosome-negative [Ph−] and 26 Philadelphia chromosome-positive [Ph+]) and 140 had a diagnosis of R/R B-cell ALL (106 Ph− and 34 Ph+). In the MRD+ group, within the first cycle of blinatumomab treatment, 93% (n = 49/53) of Ph− and 64% (n = 7/11) of Ph+ patients with evaluable MRD achieved an MRD response (MRD <0.01%). Median overall survival (OS) was not reached over a median follow-up time of 18.5 months (Ph−, 18.8 [range: 5.1–34.8] months; Ph+, 16.5 [range: 1.8–31.6] months). In the R/R group, within two cycles of blinatumomab, 51% of Ph− and 41% of Ph+ patients achieved complete hematologic remission (CR/CRh/CRi), and 83% of Ph− and 67% of Ph+ MRD-evaluable patients in CR/CRh/CRi achieved an MRD response. Median (95% confidence interval) OS was 12.2 (7.3–24.2) months in the R/R Ph− subgroup and 16.3 (5.3–not estimated) months in the R/R Ph+ subgroup. This large, real-world data set of adults with B-cell ALL treated with blinatumomab confirms efficacy outcomes from published studies.
Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment
Authors: von Beck Kelly , von Beck Troy , Ferrell P. Brent , Bick Alexander G. , Kishtagari Ashwin 
Published: January 2023

AbstractClonal hematopoiesis (CH) is the age-related expansion of hematopoietic stem cell clones caused by the acquisition of somatic point mutations or mosaic chromosomal alterations (mCAs). Clonal hematopoiesis caused by somatic mutations has primarily been associated with increased risk of myeloid malignancies, while mCAs have been associated with increased risk of lymphoid malignancies. A recent study by Niroula et al. challenged this paradigm by finding a distinct subset of somatic mutations and mCAs that are associated with increased risk of lymphoid malignancy. CH driven by these mutations is termed lymphoid clonal hematopoiesis (L-CH). Unlike myeloid clonal hematopoiesis (M-CH), L-CH has the potential to originate at both stem cells and partially or fully differentiated progeny stages of maturation. In this review, we explore the definition of L-CH in the context of lymphocyte maturation and lymphoid malignancy precursor disorders, the evidence for L-CH in late-onset autoimmunity and immunodeficiency, and the development of therapy-related L-CH following chemotherapy or hematopoietic stem cell transplantation.
Cerebro-cerebellar networks facilitate learning through feedback decoupling
Authors: Boven Ellen , Pemberton Joseph , Chadderton Paul , Apps Richard , Costa Rui Ponte 
Published: January 2023

AbstractBehavioural feedback is critical for learning in the cerebral cortex. However, such feedback is often not readily available. How the cerebral cortex learns efficiently despite the sparse nature of feedback remains unclear. Inspired by recent deep learning algorithms, we introduce a systems-level computational model of cerebro-cerebellar interactions. In this model a cerebral recurrent network receives feedback predictions from a cerebellar network, thereby decoupling learning in cerebral networks from future feedback. When trained in a simple sensorimotor task the model shows faster learning and reduced dysmetria-like behaviours, in line with the widely observed functional impact of the cerebellum. Next, we demonstrate that these results generalise to more complex motor and cognitive tasks. Finally, the model makes several experimentally testable predictions regarding cerebro-cerebellar task-specific representations over learning, task-specific benefits of cerebellar predictions and the differential impact of cerebellar and inferior olive lesions. Overall, our work offers a theoretical framework of cerebro-cerebellar networks as feedback decoupling machines.
HIV silencing and cell survival signatures in infected T cell reservoirs
Authors: Clark Iain C. , Mudvari Prakriti , Thaploo Shravan , Smith Samuel , Abu-Laban Mohammad , Hamouda Mehdi , Theberge Marc , Shah Sakshi , Ko Sung Hee , Pérez Liliana , Bunis Daniel G. , Lee James S. , Kilam Divya , Zakaria Saami , Choi Sally , Darko Samuel , Henry Amy R. , Wheeler Michael A. , Hoh Rebecca , Butrus Salwan , Deeks Steven G. , Quintana Francisco J. , Douek Daniel C. , Abate Adam R. , Boritz Eli A. 
Published: January 2023

AbstractRare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier to HIV cure1–3, but the infeasibility of isolating and characterizing these cells in their natural state has led to uncertainty about whether they possess distinctive attributes that HIV cure-directed therapies might exploit. Here we address this challenge using a microfluidic technology that isolates the transcriptomes of HIV-infected cells based solely on the detection of HIV DNA. HIV-DNA+ memory CD4 T cells in the blood from people receiving antiretroviral therapy showed inhibition of six transcriptomic pathways, including death receptor signalling, necroptosis signalling and antiproliferative Gα12/13 signalling. Moreover, two groups of genes identified by network co-expression analysis were significantly associated with HIV-DNA+ cells. These genes (n = 145) accounted for just 0.81% of the measured transcriptome and included negative regulators of HIV transcription that were higher in HIV-DNA+ cells, positive regulators of HIV transcription that were lower in HIV-DNA+ cells, and other genes involved in RNA processing, negative regulation of mRNA translation, and regulation of cell state and fate. These findings reveal that HIV-infected memory CD4 T cells under antiretroviral therapy are a distinctive population with host gene expression patterns that favour HIV silencing, cell survival and cell proliferation, with important implications for the development of HIV cure strategies.
An efficient annotation method for image recognition of dental instruments
Authors: Oka Shintaro , Nozaki Kazunori , Hayashi Mikako 
Published: January 2023

AbstractTo prevent needlestick injury and leftover instruments, and to perform efficient dental treatment, it is important to know the instruments required during dental treatment. Therefore, we will obtain a dataset for image recognition of dental treatment instruments, develop a system for detecting dental treatment instruments during treatment by image recognition, and evaluate the performance of the system to establish a method for detecting instruments during treatment. We created an image recognition dataset using 23 types of instruments commonly used in the Department of Restorative Dentistry and Endodontology at Osaka University Dental Hospital and a surgeon’s hands as detection targets. Two types of datasets were created: one annotated with only the characteristic parts of the instruments, and the other annotated with the entire parts of instruments. YOLOv4 and YOLOv7 were used as the image recognition system. The performance of the system was evaluated in terms of two metrics: detection accuracy (DA), which indicates the probability of correctly detecting the number of target instruments in an image, and the average precision (AP). When using YOLOv4, the mean DA and AP were 89.3% and 70.9%, respectively, when the characteristic parts of the instruments were annotated and 85.3% and 59.9%, respectively, when the entire parts of the instruments were annotated. When using YOLOv7, the mean DA and AP were 89.7% and 80.8%, respectively, when the characteristic parts of the instruments were annotated and 84.4% and 63.5%, respectively, when the entire parts of the instruments were annotated. The detection of dental instruments can be performed efficiently by targeting the parts characterizing them.
The effects of low-level laser therapy on muscle strength and functional outcomes in individuals with knee osteoarthritis: a double-blinded randomized controlled trial
Authors: Jankaew Amornthep , You Yu-Lin , Yang Tai-Hua , Chang Yu-Wei , Lin Cheng-Feng 
Published: January 2023

AbstractThe purpose of this study was to compare the therapeutic effects of low-level laser therapy (LLLT) with 808 and 660 nm wavelength on muscle strength and functional outcomes in individuals with knee osteoarthritis (OA). A total of 47 participants were randomly assigned to the 808 nm, 660 nm, and sham control groups. Two LLLT groups received continuous LLLT with a mean power of 300 mW in different wavelengths at the knee joint 15 min a session three days per week for eight weeks, while the control group received the sham LED treatment. The knee strength and functional performance involving 30-s sit-to-stand, 40 m fast-paced walk, stair climbing, and the TUG test were measured at the baseline and one week after the interventions were completed. The results showed that knee extensor strength was more improved in the 808 nm group as compared to the 660 nm group (p < 0.001, d = 0.57) and the sham control (p < 0.001, d = 0.40), while increased flexor strength was demonstrated in the 808 nm (p = 0.009, d = 0.67) and sham control groups (p < 0.001, d = 0.97). The number of 30-s sit-to-stand was increased only in the 660 nm group (p = 0.006, d = 0.49). All three groups exhibited improvements in the other three functional performance-based tests after the interventions with no statistically significant differences among the groups. In conclusion, both intervention groups improved muscle strength and functional performance as compared to the control group. The 808 nm wavelength group showed better results in knee extensor strength. Therefore, laser therapy is suggested to be integrated into rehabilitation programs to improve muscle strength and functional performance in the population with knee OA.
Aedes albopictus host odor preference does not drive observed variation in feeding patterns across field populations
Authors: Fikrig Kara , Rose Noah , Burkett-Cadena Nathan , Kamgang Basile , Leisnham Paul T. , Mangan Jamie , Ponlawat Alongkot , Rothman Sarah E. , Stenn Tanise , McBride Carolyn S. , Harrington Laura C. 
Published: January 2023

AbstractLaboratory and field-based studies of the invasive mosquito Aedes albopictus demonstrate its competency to transmit over twenty different pathogens linked to a broad range of vertebrate hosts. The vectorial capacity of Ae. albopictus to transmit these pathogens remains unclear, partly due to knowledge gaps regarding its feeding behavior. Blood meal analyses from field-captured specimens have shown vastly different feeding patterns, with a wide range of anthropophagy (human feeding) and host diversity. To address this knowledge gap, we asked whether differences in innate host preference may drive observed variation in Ae. albopictus feeding patterns in nature. Low generation colonies (F2–F4) were established with field-collected mosquitoes from three populations with high reported anthropophagy (Thailand, Cameroon, and Florida, USA) and three populations in the United States with low reported anthropophagy (New York, Maryland, and Virginia). The preference of these Ae. albopictus colonies for human versus non-human animal odor was assessed in a dual-port olfactometer along with control Ae. aegypti colonies already known to show divergent behavior in this assay. All Ae. albopictus colonies were less likely (p < 0.05) to choose the human-baited port than the anthropophilic Ae. aegypti control, instead behaving similarly to zoophilic Ae. aegypti. Our results suggest that variation in reported Ae. albopictus feeding patterns are not driven by differences in innate host preference, but may result from differences in host availability. This work is the first to compare Ae. albopictus and Ae. aegypti host preference directly and provides insight into differential vectorial capacity and human feeding risk.
Evaluation of the extraction of methodological study characteristics with JATSdecoder
Authors: Böschen Ingmar 
Published: January 2023

AbstractThis paper introduces and evaluates the study.character module from the JATSdecoder package which extracts several key methodological study characteristics from NISO-JATS coded scientific articles. study.character splits the text into sections and applies its heuristic-driven extraction procedures to the text of the method and result section/s. When used individually, study.character’s functions can also be applied to any textual input. An externally coded data set of 288 PDF articles serves as an indicator of study.character’s capabilities in extracting the number of sub-studies reported per article, the statistical methods applied and software solutions used. Its precision of extraction of the reported $$\alpha $$
α
-level, power, correction procedures for multiple testing, use of interactions, definition of outlier, and mentions of statistical assumptions are evaluated by a comparison to a manually curated data set of the same collection of articles. Sensitivity, specificity, and accuracy measures are reported for each of the evaluated functions. study.character reliably extracts the methodological study characteristics targeted here from psychological research articles. Most extractions have very low false positive rates and high accuracy ($$\ge 0.9$$

≥
0.9

). Most non-detections are due to PDF-specific conversion errors and complex text structures, that are not yet manageable. study.character can be applied to large text resources in order to examine methodological trends over time, by journal and/or by topic. It also enables a new way of identifying study sets for meta-analyzes and systematic reviews.
Learning-based physical models of room-temperature semiconductor detectors with reduced data
Authors: Banerjee Srutarshi , Rodrigues Miesher , Ballester Manuel , Vija Alexander Hans , Katsaggelos Aggelos K. 
Published: January 2023

AbstractRoom-temperature semiconductor radiation detectors (RTSD) have broad applications in medical imaging, homeland security, astrophysics and others. RTSDs such as CdZnTe, CdTe are often pixelated, and characterization of these detectors at micron level can benefit 3-D event reconstruction at sub-pixel level. Material defects alongwith electron and hole charge transport properties need to be characterized which requires several experimental setups and is labor intensive. The current state-of-art approaches characterize each detector pixel, considering the detector in bulk. In this article, we propose a new microscopic learning-based physical models of RTSD based on limited data compared to what is dictated by the physical equations. Our learning models uses a physical charge transport considering trapping centers. Our models learn these material properties in an indirect manner from the measurable signals at the electrodes and/or free and/or trapped charges distributed in the RTSD for electron–hole charge pair injections in the material. Based on the amount of data used during training our physical model, our algorithm characterizes the detector for charge drifts, trapping, detrapping and recombination coefficients considering multiple trapping centers or as a single equivalent trapping center. The RTSD is segmented into voxels spatially, and in each voxel, the material properties are modeled as learnable parameters. Depending on the amount of data, our models can characterize the RTSD either completely or in an equivalent manner.