bluuebunny/crossref_metadata_2025_split huggingface dataset:
A real-world comparison of the clinical and economic utility of OVA1 and CA125 in assessing ovarian tumor malignancy risk
Authors: Reilly Gerard P , Gregory David A , Scotti Dennis J , Lederman Samuel , Neiman Wade A , Sussman Steven , M Bean Lisa , Ekono Mercedes M 
Published: May 2023

Aim:
This largest-of-its-kind study evaluated the clinical utility of CA125 and OVA1, commonly used as ovarian tumor markers for assessing the risk of malignancy. The research focused on the ability and utility of these tests to reliably predict patients at low risk for ovarian cancer. Clinical utility endpoints were 12-month maintenance of benign mass status, reduction in gynecologic oncologist referral, avoidable surgical intervention and associated cost savings.
Materials

& methods:
This was a multicenter retrospective review of data from electronic medical records and administrative claims databases. Patients receiving a CA125 or OVA1 test between October 2018 and September 2020 were identified and followed for 12 months using site-specific electronic medical records to assess tumor status and utilization outcomes. Propensity score adjustment was used to control for confounding variables. Payer allowed amounts from Merative MarketScan Research Databases were used to estimate 12-month episode-of-care costs per patient, including surgery and other interventions.
Results:
Among 290 low-risk OVA1 patients, 99.0% remained benign for 12 months compared with 97.2% of 181 low-risk CA125 patients. The OVA1 cohort exhibited 75% lower odds of surgical intervention in the overall sample of patients (Adjusted OR: 0.251, p ≤ 0.0001), and 63% lower odds of gynecologic oncologist utilization among premenopausal women (Adjusted OR: 0.37, p = 0.0390) versus CA125. OVA1 demonstrated significant savings in surgical interventions ($2486, p ≤ 0.0001) and total episode-of-care costs ($2621, p ≤ 0.0001) versus CA125.
Conclusion:
This study underscores the utility of a reliably predictive multivariate assay for assessing ovarian cancer risk. For patients assessed at low risk of ovarian tumor malignancy, OVA1 is associated with a significant reduction in avoidable surgeries and substantial cost savings per patient. OVA1 is also associated with a significant reduction in subspecialty referrals for low-risk premenopausal patients.
HUBUNGAN JARAK DAN DURASI PENGGUNAAN GADGET DENGAN KELELAHAN MATA PADA MAHASISWA UNIVERSITAS SULAWESI BARAT
Authors: Ners Irfan Irfan , Paida Nur , Yunding Junaedi , R Muhammad Amin 
Published: May 2023

Abstrak
Latar belakang: Di era globalisasi, teknologi informasi sedang berkembang pesat dan membawa pengaruh besar di berbagai bidang, salah satunya pendidikan. Pendidikan sangat terbantu dengan hadirnya teknologi yang mendukung kegiatan belajar yang lebih variatif dan kreatif. Saat ini setiap orang diseluruh dunia pasti sudah mempunyai gadget. bahkan pengguna gadget bukan hanya di kalangan usia dewasa saja, namun juga di kalangan remaja, anak-anak bahkan balita. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan antara jarak dan durasi pada penggunaan gadget terhadap kelelahan mata pada mahasiswa Fakultas Ilmu Kesehatan Universitas Sulawesi Barat. Jenis penelitian: menggunakan cross sectional dengan metode probability sampling. Dengan jumlah sampel 312 responden. Hasil: Durasi penggunaan gadget kurang baik sebanyak 167, responden dan untuk kategori baik 137. Jarak penggunaan gadget kurang baik sebanyak 120 responden dan untuk kategori baik sebanyak 192 responden. Dan yang mengalami kelelahan mata sebanyak 293, yang tidak mengalami sebanyak 19 responden. Uji chi square menunjukan tidak ada hubungan durasi dan jarak penggunaan gadget dengan kelelahan dengan nilai p value (0,694) > (0,05). Saran: diharapkan kepada mahasiswa untuk melakukan penelitian lebih lanjut terkait penggunaan gadget untuk lebih mengetahui akan hubungan penggunaan gadget terhadap kelelahan mata.
The Implementation of Japanese Animation (Anime) In Advertising
Authors: Aziz Munafsin , Ong Susy 
Published: May 2023

Anime has become a popular culture phenomenon in Japan and around the world. The use of anime in advertisements has become one of the most effective marketing strategies in Japan. This article discusses the use of anime in advertisements in Japan, as well as the advantages of using anime in advertisements.
This article explains the popularity of anime in Japan and how it has become a part of the country's consumer culture. Then, this article also discusses how anime is used in advertising to attract consumer attention and increase product sales.
Furthermore, this article discusses the advantages of using anime in advertisements, including being effective in reaching a young market, increasing brand appeal, and giving a more attractive and unique impression to the advertised product.
In this article, it is also explained that the use of anime in advertising can also increase consumer engagement and build an emotional connection between brands and consumers. Apart from that, this article also contains examples of advertisements using anime, both in the private and government sectors.
Anime can also help brands create positive and imaginative images that can enhance brand impressions. Overall, the use of anime in advertising in Japan has many advantages and is an effective marketing strategy.
KETAHANAN KELUARGA DI MASA PANDEMI COVID-19 MASYARAKAT DESA CISUMUR PRESPEKTIF SAKINAH
Authors: Fauzan Annida Fathiyah 
Published: May 2023

Pandemi covid 19 merupakan bencana pandemi yang melanda seluruh dunia khususnya dinegara indonesia, kebijakan pemerintah melakukan social distensing dan melakukan karantina wilayah secara persial untuk mengurangi pembatasan kegiatan diluar dan meminimalisir tingkat penularan virus corona. Hal tersebut membuat situasi hampir disemua aspek kehidupan mengalami hal yang baru terutama pada perubahan pola rantai pasok pangan sehingga dampak dari pandemi juga menyebabkan perekonomian negara mengalami kontraksi yang sangat signifikan, banyak pekerja sektor formal yang terkena putus hubungan kerja (PHK), para pengusaha, perusahaan, bakhan pedagang kaki lima juga banyak yang mengalami gulung tikar. Seperti yang terjadi didaerah Cisumur Gandrungmangu ada sebagian wanita yang bekerja membantu suaminya untuk tetap mempertahankan keluarganya sehingga waktu bersama keluarga dan komunikasi antar keluarga juga berkurang. Oleh sebab itu penulis tertarik untuk meneliti lebih lanjut mengenai bagaimana kondisi masyarakat desa Cisumur dimasa pandemi dan apa upaya yang dilakukan masyarakat untuk menjaga ketahanan keluarga. Untuk meneliti keadaan yang lebih lanjut peneliti melakukan wawancara langsung bersama masyarakat desa Cisumur guna mengetahui keadaan masyarakat desa tersebut. Pada kondisi seperti ini tentu sangat mempengaruhi keadaan keluarga terutama pada tingkat ekonomi, sehingga banyak terjadi kasus perceraian kekerasan dalam rumah tangga. Salah satu upaya yang penting dilakukan adalah dengan memperkokoh resiliensi keluarga. Karena apabila pasangan suami dan istri tidak dapat memperkokoh resiliensi keluarga maka akan timbul problem-problem dalam rumah tangga yang semakin menjadi. Berikut definisi sakinah mawaddah warahmah sebagai bekal dalam keluarga.
Tilfredshet og fremtidsplaner blant nyutdannede sykepleiere ett år etter endt utdanning
Authors: Bjerkvik Liv Karin , Valeberg Berit Taraldsen 
Published: May 2023

Hensikt: Å kartlegge faktorer som påvirker nyutdannede sykepleieres tilfredshet og videre yrkesplaner. Metode: Elektronisk spørreundersøkelse våren 2018. Resultat: 129 (36%) av 360 inviterte sykpleiere uteksaminerte våren 2017 deltok. Flertallet var tilfredse med yrkesvalget, oppfattet seg som sykepleiere og planla videreutdanning. En fjerdedel planla å slutte i stillingen. En femtedel vurderte å bytte yrke. Høy tilfredshet korrelerte med et faglig stimulerende arbeidsmiljø, mulighet til å yte sykepleie i samsvar med egne verdier og lav sannsynlighet for å bytte stillingen og yrke. Selvstendig ansvar og et støttende arbeidsmiljø, tilbakemelding på arbeidet og høy stillingsbrøk korrelerte med høy faglig selvtillit. Deltidsstilling økte sannsynligheten for turnover. Konklusjon: Nyutdannede vektlegger muligheter for fagutvikling og kvalitet i arbeidet, og har lav terskel for å slutte i stilling og yrke når forventninger ikke innfris. Det er behov for mer kunnskap om hvordan forventninger og faglige verdier påvirker integrering i yrkesrollen for å forebygge tendens til høy turnover og tidlig frafall.
Facing the infinity: tackling large samples of challenging Chironomidae (Diptera) with an integrative approach
Authors: Chimeno Caroline , Rulik Björn , Manfrin Alessandro , Kalinkat Gregor , Hölker Franz , Baranov Viktor 
Published: May 2023

Background
Integrative taxonomy is becoming ever more significant in biodiversity research as scientists are tackling increasingly taxonomically challenging groups. Implementing a combined approach not only guarantees more accurate species identification, but also helps overcome limitations that each method presents when applied on its own. In this study, we present one application of integrative taxonomy for the highly abundant and particularly diverse fly taxon Chironomidae (Diptera). Although non-biting midges are key organisms in merolimnic systems, they are often cast aside in ecological surveys because they are very challenging to identify and extremely abundant.

Methods
Here, we demonstrate one way of applying integrative methods to tackle this highly diverse taxon. We present a three-level subsampling method to drastically reduce the workload of bulk sample processing, then apply morphological and molecular identification methods in parallel to evaluate species diversity and to examine inconsistencies across methods.

Results
Our results suggest that using our subsampling approach, identifying less than 10% of a sample’s contents can reliably detect >90% of its diversity. However, despite reducing the processing workload drastically, the performance of our taxonomist was affected by mistakes, caused by large amounts of material. We conducted misidentifications for 9% of vouchers, which may not have been recovered had we not applied a second identification method. On the other hand, we were able to provide species information in cases where molecular methods could not, which was the case for 14% of vouchers. Therefore, we conclude that when wanting to implement non-biting midges into ecological frameworks, it is imperative to use an integrative approach.
Knowledge and Adoption of the Respondent about the Livestock Insurance Scheme
Authors: Katal Khushboo , Mazhar Syed H. 
Published: May 2023

The present investigation was conducted in Dhariwal block of Gurdaspur district, Punjab. One hundred twenty respondents were selected purposively from 5 villages. The primary data were gathered by the researcher itself through pre-structured interview schedule. Appropriate statistical tools were used to interpret the collected data to draw logical conclusion. The finding inferred that the majority of respondents having low level of adoption towards livestock insurance scheme. And also, it was observed that most of the respondents had medium level of knowledge towards livestock insurance scheme. And age, education, family type, type of house, land holding, occupation, source of information, extension contact and personnel cosmopolite were observed positive and significant correlation with their knowledge level. And age, education, family type, family size, land holding, occupation, annual income, source of information, extension contact, personnel cosmopolite were observed positive and significant co-relation with their adoption level.
Smart Greenhouse Monitoring System Using Blynk IoT App
Authors: Shanto Shakib Sadat , Rahman Mushfiqur , Oasik Jaber Md. , Hossain Hamim 
Published: May 2023

Aims: A smart greenhouse system that utilizes the Blynk IoT app is an innovative technology designed to automate greenhouse operations, thereby reducing labor and resource costs and optimizing plant growth.
Study Design: In this paper we propose a real-time mobile app-based monitoring system to automate greenhouse agriculture. The system involves the usage of Blynk mobile application that allows users to monitor, control both manually and remotely as well as automation of various aspects of the greenhouse environment in real-time.
Place and Duration of Study: Department of Computer Science and Engineering, American International University-Bangladesh (AIUB), Dhaka, Bangladesh between February 2023 to April 2023.
Methodology: Multiple environmental sensors, temperature, humidity, soil moisture, light intensity, and Light Dependent Resistor (LDR) sensors continuously collect data. Farmers can remotely monitor and control the greenhouse using the Blynk IoT application. A fire sensor alarms it. Farmers can tailor alerts for environmental changes like irrigation or heating. They can manually and remotely control fans, lights, and humidifiers. If temperature, light intensity, or humidity drop below a specified threshold, the system turns on fans, lights, and humidifiers. A water pump that kicks on automatically based on soil moisture and can be regulated remotely ensures the plants get enough water.
Results: The proposed system allows for real-time updates of sensor data and enables remote control of connected devices via the mobile app from any location, with notable fast processing subject to the quality of the internet connection.
Conclusion: Upon successful implementation of this research, we anticipate the emergence of an advanced automated smart greenhouse monitoring system that will greatly benefit farmers in Bangladesh. This new method could change greenhouse and farm management, improving efficiency, cost, and crop yields.
Trends in Methadone Dispensing for Opioid Use Disorder After Medicare Payment Policy Changes
Authors: Taylor Erin A. , Cantor Jonathan H. , Bradford Ashley C. , Simon Kosali , Stein Bradley D. 
Published: May 2023

ImportanceA significant proportion of Medicare beneficiaries have a diagnosed opioid use disorder (OUD). Methadone and buprenorphine are both effective medications for the treatment of OUD (MOUDs); however, Medicare did not cover methadone until 2020.ObjectiveTo examine trends in methadone and buprenorphine dispensing among Medicare Advantage (MA) enrollees after 2 policy changes in 2020 related to methadone access.Design, Setting, and ParticipantsThis cross-sectional analysis of temporal trends in methadone and buprenorphine treatment dispensing assessed MA beneficiary claims from January 1, 2019, through March 31, 2022, captured by Optum’s Clinformatics Data Mart. Of 9 870 791 MA enrollees included in the database, 39 252 had at least 1 claim for methadone, buprenorphine, or both during the study period. All available MA enrollees were included. Subanalyses by age and dual eligibility for Medicare and Medicaid status were conducted.ExposuresStudy exposures were (1) the Centers for Medicare &amp;amp; Medicaid Services (CMS) Medicare bundled payment reimbursement policy for OUD treatment and (2) the Substance Abuse and Mental Health Administration and CMS Medicare policies designed to facilitate access to treatment for OUD, specifically during the COVID-19 pandemic.Main Outcomes and MeasuresStudy outcomes were trends in methadone and buprenorphine dispensing by beneficiary characteristics. National methadone and buprenorphine dispensing rates were calculated as claims-based dispensing rates per 1000 MA enrollees.ResultsAmong the 39 252 MA enrollees with at least 1 MOUD dispensing claim (mean age, 58.6 [95% CI, 58.57-58.62] years; 45.9% female), 195 196 methadone claims and 540 564 buprenorphine pharmacy claims were identified, for a total of 735 760 dispensing claims. The methadone dispensing rate for MA enrollees was 0 in 2019 because the policy did not allow any payment until 2020. Claims rates per 1000 MA enrollees were low initially, increasing from 0.98 in the first quarter of 2020 to 4.71 in the first quarter of 2022. Increases were primarily associated with dually eligible beneficiaries and beneficiaries younger than 65 years. National buprenorphine dispensing rates were 4.64 per 1000 enrollees in quarter 1 of 2019, increasing to 7.45 per 1000 enrollees in quarter 1 of 2022.Conclusions and RelevanceThis cross-sectional study found that methadone dispensing increased among Medicare beneficiaries after the policy changes. Rates of buprenorphine dispensing did not provide evidence that beneficiaries substituted buprenorphine for methadone. The 2 new CMS policies represent an important first step in increasing access to MOUD treatment for Medicare beneficiaries.
California awards $17 million for SUD prevention for youth
Authors: Knopf Alison 
Published: May 2023

This month Gov. Gavin Newsom of California announced that almost $17 million has been awarded to 44 community‐based and tribal organizations to develop and increase substance use disorder (SUD) prevention services through civic engagement and culturally competent programs. These awards are part of Elevate Youth California, a statewide Department of Health Care Services (DHCS) initiative to help grassroots community‐based and tribal organizations develop programs for young people living in communities that are disproportionately impacted by the war on drugs.
Photonic Amorphous I‐WP‐Like Networks Create Angle‐Independent Colors inSternotomis virescensLonghorn Beetles
Authors: Bauernfeind Viola , Djeghdi Kenza , Gunkel Ilja , Steiner Ullrich , Wilts Bodo D. 
Published: May 2023

AbstractStructural color originates from the interference of light with periodic structures that feature characteristic length scales on the order of the wavelength of visible light. Long‐range order in photonic structures usually causes iridescence, and increasing disorder renders colors angle‐independent. Random disorder distributes scattering intensity over all wavelengths, producing white in the absence of absorption. Various non‐iridescent, vivid color patterns are found inSternotominilonghorn beetles. Herein,Sternotomis virescensis investigated, where elytral scales produce a green‐blue color pattern on otherwise black elytra. Combining focused ion beam scanning electron microscopy (FIB‐SEM) tomography, ultra‐small‐angle X‐ray scattering (USAXS), structural modeling, and full‐wave optical simulations, it is found that the color originates from amorphous photonic networks based on sub‐units resembling the I‐WP unit cell, a triply‐periodic minimal surface with body‐centered‐cubic symmetry. This work provides insights into how quasi‐order produces stable colors inS. virescenslonghorn beetles, highlights the advantages of volumetric imaging using FIB‐SEM tomography of porous nanostructured materials, and raises interesting questions about the formation mechanisms of amorphous structures in vivo.
A Mitochondria‐Targeted Ferroptosis Inducer Activated by Glutathione‐Responsive Imaging and Depletion for Triple Negative Breast Cancer Theranostics
Authors: Gan Hongbo , Huang Xie , Luo Xi , Li Jinlin , Mo Banghui , Cheng Lizhi , Shu Qiuxia , Du Zaizhi , Tang Hong , Sun Wei , Wang Liting , Luo Shenglin , Yu Songtao 
Published: May 2023

AbstractFerroptosis is a new type of iron‐dependent programmed cell death characterized by glutathione (GSH) depletion, selenoprotein glutathione peroxidase 4 (GPX4) inactivation, and lipid peroxides accumulation. Mitochondria, as the main source of intracellular energy supply and reactive oxygen species (ROS) generation, play a central role in oxidative phosphorylation and redox homeostasis. Therefore, targeting cancer‐cell mitochondria and attacking redox homeostasis is expected to induce robust ferroptosis‐mediated anticancer effects. In this work, a theranostic ferroptosis inducer (IR780‐SPhF), which can simultaneously achieve the imaging and therapy of triple‐negative breast cancer (TNBC) by targeting mitochondria is presented. It is developed from a mitochondria‐targeting small molecule (IR780) with cancer‐preferential accumulation, enabling it to react with GSH by nucleophilic substitution, resulting in mitochondrial GSH depletion and redox imbalance. More interestingly, IR780‐SPhF exhibits GSH‐responsive near‐infrared fluorescence emission and photoacoustic imaging characteristics, further facilitating diagnosis and treatment with real‐time monitoring of TNBC with a highly elevated GSH level. Both in vitro and in vivo results demonstrate that IR780‐SPhF exhibits potent anticancer effect, which is significantly stronger than cyclophosphamide, a classic drug commonly recommended for TNBC patients in clinic. Hence, the reported mitochondria‐targeted ferroptosis inducer may represent a promising candidate and a prospective strategy for efficient cancer treatment.
Precise Engineering of a Se/Te Nanochaperone for Reinvigorating Cancer Radio‐Immunotherapy
Authors: Chang Yanzhou , Huang Jiarun , Shi Sujiang , Xu Ligeng , Lin Hao , Chen Tianfeng 
Published: May 2023

AbstractFacilely synthesized nanoradiosensitizers with well‐controlled structure and multifunctionality are greatly desired to address the challenges of cancer radiotherapy. In this work, a universal method is developed for synthesizing chalcogen‐based TeSe nano‐heterojunctions (NHJs) with rod‐, spindle‐, or dumbbell‐like morphologies by engineering the surfactant and added selenite. Interestingly, dumbbell‐shaped TeSe NHJs (TeSe NDs) as chaperone exhibit better radio‐sensitizing activities than the other two nanostructural shapes. Meanwhile, TeSe NDs can serve as cytotoxic chemodrugs that degrade to highly toxic metabolites in acidic environment and deplete GSH within tumor to facilitate radiotherapy. More importantly, the combination of TeSe NDs with radiotherapy significantly decreases regulatory T cells and M2‐phenotype tumor‐associated macrophage infiltrations within tumors to reshape the immunosuppressive microenvironment and induce robust T lymphocytes‐mediated antitumor immunity, resulting in great abscopal effects on combating distant tumor progression. This study provides a universal method for preparing NHJ with well‐controlled structure and developing nanoradiosensitizers to overcome the clinical challenges of cancer radiotherapy.
Ultrafast‐Programmable 2D Homojunctions Based on van der Waals Heterostructures on a Silicon Substrate
Authors: Wang Hao , Bao Lihong , Guzman Roger , Wu Kang , Wang Aiwei , Liu Li , Wu Liangmei , Chen Jiancui , Huan Qing , Zhou Wu , Pantelides Sokrates T. , Gao Hong‐Jun 
Published: May 2023

AbstractThe development of electrically ultrafast‐programmable semiconductor homojunctions can lead to transformative multifunctional electronic devices. However, silicon‐based homojunctions are not programmable so that alternative materials need to be explored. Here 2D, multi‐functional, lateral homojunctions made of van der Waals heterostructures with a semi‐floating‐gate configuration on a p++ Si substrate feature atomically sharp interfaces and can be electrostatically programmed in nanoseconds, more than seven orders of magnitude faster than other 2D‐based homojunctions. By applying voltage pulses with different polarities, lateral p−n, n+−n and other types of homojunctions can be formed, varied, and reversed. The p−n homojunctions possess a high rectification ratio of up to ≈105 and can be dynamically switched between four distinct conduction states with the current spanning over nine orders of magnitude, enabling them to function as logic rectifiers, memories, and multi‐valued logic inverters. Built on a p++ Si substrate, which acts as the control gate, the devices are compatible with Si technology.