bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Informasi Administrasi Desa Sejati Kecamatan Rambah Hilir Menggunakan Framework Laravel
Authors: Yasdomi Kiki , Sabri Khairul , Utami Urfi , Dona  , Khoiri Amrul 
Published: July 2023

Pelayanan administrasi kemasyarakatan desa sejati harus bolak-balik dengan kantor desa jika persyaratan administrasi tidak ada. Mengirimkan informasi tentang kegiatan desa melalui surat dan orang ke orang. Dengan menggunakan framework Laravel, sistem informasi manajemen desa yang sebenarnya dapat dibangun dengan metode waterfall, yang dapat dikomputerisasi menjadi lebih cepat dan lebih akurat. Aplikasi ini terdiri dari dua bagian, yaitu perangkat desa dan perangkat masyarakat. Bagian pertama mencetak akte ketidakmampuan, akte kelahiran, surat pernikahan, izin orang tua, dan dokumen pernikahan dan jenis kelamin untuk perjanjian administrasi pdf. Selain itu, masyarakat dapat melihat informasi tentang berita, agenda, dan dokumen tentang kegiatan desa terbaru.
Tough, adhesive biomimetic hyaluronic acid methacryloyl hydrogels for effective wound healing
Authors: Peng Zhiwei , Xue Huai , Liu Xiao , Wang Shuguang , Liu Guodong , Jia Xinghai , Zhu Ziqiang , Orvy Moontarij Jahan , Yang Yin , Wang Yunqing , Zhang Dong , Tong Lei 
Published: July 2023

The development of cost-effective, biocompatible soft wound dressings is highly desirable; however, conventional dressings are only designed for flat wounds, which creates difficulty with promising healing efficiency in complex practical conditions. Herein, we developed a tough, adhesive biomimetic hyaluronic acid methacryloyl hydrogels composed of chemically crosslinked hyaluronic acid methacryloyl (HAMA) network and poly(N-hydroxyethyl acrylamide) (PHEAA) network rich in multiple hydrogen bonding. Due to the multiple chemical crosslinking sites (acrylamide groups) of HAMA; the bulk HEMA/PHEAA hydrogels presented significant enhancements in mechanical properties (∼0.45 MPa) than common hyaluronic acid hydrogels (&lt;0.1 MPa). The abundant hydrogen bonding also endowed the resultant hydrogels with extremely high adhesiveness on many nonporous substrates, including glass and biological tissues (e.g., heart, liver, lung, kidney, stomach, and muscle), with a considerable interfacial toughness of ∼1432 J m−2. Accordingly, since both natural hyaluronic acid derivative polymers and hydrophilic PHEAA networks are highly biocompatible, the hydrogel matrix possesses good blood compatibility (&lt;5% of hemolysis ratio) and satisfies the general dressing requirements (&gt;99% of cell viability). Based on these physicochemical features, we have demonstrated that this adhesive hydrogel, administered in the form of a designed patch, could be applied to wound tissue healing by promoting epithelialization, angiogenesis, and collagen deposition. We believe that our proposed biomimetic hydrogel design holds great potential for wound repair and our developed HAMA/PHEAA hydrogels are extremely promising for the next-generation tissue healings in emergency situations.
The effects of P2Y12 adenosine receptors’ inhibitors on central and peripheral chemoreflexes
Authors: Tubek Stanislaw , Niewinski Piotr , Langner-Hetmanczuk Anna , Jura Maksym , Kuliczkowski Wiktor , Reczuch Krzysztof , Ponikowski Piotr 
Published: July 2023

Introduction: The most common side effect of ticagrelor is dyspnea, which leads to premature withdrawal of this life-saving medication in 6.5% of patients. Increased chemoreceptors’ sensitivity was suggested as a possible pathophysiological explanation of this phenomenon; however, the link between oversensitization of peripheral and/or central chemosensory areas and ticagrelor intake has not been conclusively proved.Methods: We measured peripheral chemoreceptors’ sensitivity using hypoxic ventilatory response (HVR), central chemoreceptors’ sensitivity using hypercapnic hyperoxic ventilatory response (HCVR), and dyspnea severity before and 4 ± 1 weeks following ticagrelor initiation in 11 subjects with chronic coronary syndrome undergoing percutaneous coronary intervention (PCI). The same tests were performed in 11 age-, sex-, and BMI-matched patients treated with clopidogrel. The study is registered at ClinicalTrials.com at NCT05080478.Results: Ticagrelor significantly increased both HVR (0.52 ± 0.46 vs. 0.84 ± 0.69 L min-1 %−1; p &lt; 0.01) and HCVR (1.05 ± 0.64 vs. 1.75 ± 1.04 L min−1 mmHg−1; p &lt; 0.01). The absolute change in HVR correlated with the change in HCVR. Clopidogrel administration did not significantly influence HVR (0.63 ± 0.32 vs. 0.58 ± 0.33 L min-1%−1; p = 0.53) and HCVR (1.22 ± 0.67 vs. 1.2 ± 0.64 L min−1 mmHg−1; p = 0.79). Drug-related dyspnea was reported by three subjects in the ticagrelor group and by none in the clopidogrel group. These patients were characterized by either high baseline HVR and HCVR or excessive increase in HVR following ticagrelor initiation.Discussion: Ticagrelor, contrary to clopidogrel, sensitizes both peripheral and central facets of chemodetection. Two potential mechanisms of ticagrelor-induced dyspnea have been identified: 1) high baseline HVR and HCVR or 2) excessive increase in HVR or HVR and HCVR. Whether other patterns of changes in chemosensitivities play a role in the pathogenesis of this phenomenon needs to be further investigated.
Trastuzumab Deruxtecan (Enhertu)
Authors: CADTH  
Published: July 2023

CADTH recommends that Enhertu be reimbursed by public drug plans for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer if certain conditions are met.
Enhertu should only be covered to treat adult patients with HER2-low breast cancer that is unresectable (cannot be removed by surgery) or metastatic (has spread to other parts of the body) who have received a prior chemotherapy for metastatic disease or had their cancer come back after surgery within 6 months of completing adjuvant chemotherapy. If the patient is hormone receptor (HR)-positive, they should have been treated with at least 1 endocrine therapy (ET) and no longer be considered candidates for further ET treatment. Patients receiving Enhertu should be in relatively good health (i.e., have a good performance status, as determined by a specialist). Patients in whom the cancer has spread to the brain or spinal cord, for whom there is spinal cord compression causing symptoms, or those with interstitial lung disease or pneumonitis should not be eligible for coverage.
Enhertu should only be reimbursed if prescribed by clinicians with experience and expertise in treating advanced breast cancer in centres, if it is not used with other cancer treatments, and if the cost of Enhertu is reduced. Patients who experience disease progression while taking Enhertu or who cannot tolerate the drug would not be eligible for continued coverage.
Formulation and evaluation of topical piroxicam microemulgel for arthritis
Authors: Mehreen Sattar  , Somia Sarfraz  , Uzma Liaquat  , Iqra Shoukat  , Bilal Ahmad  , Talib Hussain  
Published: July 2023

Background: Piroxicam is an anti-inflammatory, analgesic, and antipyretic drug. Piroxicam is widely used in the management of chronic pain. The objective of this work was to develop and analyze topical Piroxicam microemulgel to improve drug solubility, enhance permeation, reduce GIT side effects reduce the frequency of the drug. Method: The Piroxicam microemulgel was prepared by drawing the pseudo ternary phase picture and water titration procedure. Formulation was prepared by using isopropyl myristate as an oil, Tween 80 as an surfactant, n-butanol as Co-surfactant and water. It was converted to gel by using 1% Carbopol 940 and few drops of ethanolamine. The prepared formulation was characterized for thermodynamic stability, pH, droplet size, viscosity, FTIR,DSC, electrical conductivity, dye solubility drug content, and in-vitro release using a Franz diffusion cell. Result: Microemulgel formulation was thermodynamically stable on visual inspection after being treated with a freeze-thaw cycle and centrifugation. pH of formulation was 6.5. The mean droplet size for ME gel was 100±0.472nm. The viscosity of the microemulgel was 90.4±0.01 cps which showed Newtonian flow. FTIR and DSC studies showed that microemulgel was compatible with its excipients. Electrical conductivity and dye solubility testing confirmed that the microemulgel was O/W. Piroxicam microemulsion gel showed 89.89% drug content and the release rate of piroxicam was 98±8.63% after 48h. It followed the Korsmeyer Pappas model which means it was a hydrogel-based system. Conclusion: Microemulsion gel formulation obtained remarkably inflated skin retention for piroxicam over the piroxicam gel. It might act as a promising vehicle for the topical delivery of poor water-soluble drugs.
A sensitive tissue factor activity assay determined by an optimized thrombin generation method
Authors: Kristensen Søren Risom , Nybo Jette 
Published: July 2023

Background
Tissue factor (TF) is the principal activator of the coagulation system, but an increased concentration in the blood in cancer and inflammatory diseases has been suggested to play a role increasing the risk of venous thromboembolism. However, measurement of the TF concentration is difficult, and quantitation of activity is the most valid estimation. The objective of this study was to establish a sensitive method to measure TF activity based on thrombin generation.

Methods
The assay is based on thrombin generation (TG) measured on the Calibrated Automated Thrombogram (CAT). Various low concentrations of TF were prepared from reagents containing 1 pM TF and 4 μM phospholipid (PPL), and no TF and 4 μM PPL, and a calibration curve was produced from Lagtime vs TF concentration. TF in blood samples was measured after isolation and resuspension of extracellular vesicles (EVs) in a standard plasma from which EVs had been removed. The same standard plasma was used for the calibrators.

Results
Contact activation of the coagulation system was avoided using CTI plasma samples in Monovette tubes. EVs contain procoagulant phospholipids but addition of PPL only reduced lagtime slightly at very low concentrations of TF resulting in overestimation to a lesser extent at 10 fM but no interference at 30 fM or higher. Addition of EVs to the TG analysis induced a small unspecific TF-independent activity (i.e., an activity not inhibited by antibodies against TF) which also may result in a smaller error in estimation of TF activity at very low levels but the effect was negligible at higher concentrations. It was possible to measure TF activity in healthy controls which was found to be 1–6 fM (EVs were concentrated, i.e. solubilized in a lower volume than the original volume plasma). Coefficient of variation (CV) was below 20% at the low level, and below 10% at a level around 100 fM TF. However, the step with isolation of EVs have a higher inherent CV.

Conclusion
A sensitive and rather precise one-stage TG-based method to measure TF activity has been established.
АНАЛІЗ ХАРАКТЕРИСТИК МАЛОПОТУЖНОГО ФІЛЬТРА НА ТРАНЗИТОРНИХ АНАЛОГАХ ІНДУКТИВНОСТІ ЯК АЛЬТЕРНАТИВИ ФІЛЬТРІВ НА ПОВ’ЯЗАНИХ РЕЗОНАТОРАХ
Authors: ОСАДЧУК Олександр , ДУМЕНКО Денис 
Published: July 2023

У статті проаналізовано основні характеристики малопотужних смугопропускаючих фільтрів. Розглянуті фільтри на пов’язаних резонаторах та запропоновано використання транзисторних аналогів індуктивності як їх альтернатива. Досліджена зміна основних параметрів компонентів фільтрів при заміні основного елемента на транзистор. Охарактеризовані основні аспекти та досліджений коефіцієнт передачі фільтра з використанням транзисторного аналогу індуктивності. Розглянуто режим роботи малого сигналу транзистора та його основні умови. Проаналізовані умови яким потрібно слідувати при виборі активного елементу. Наведено залежність роботи та параметрів транзисторів від живлення по постійному струмові, його стабільності та безперебійності. Проаналізовано можливість використання несиметричної смугової лінії передачі з діелектричним заповненням.
The Legal transplant during the democratic transition: the regional migration of a constitutional idea : The spread of qualified law in the central and East-European regions
Authors: Szentgáli-Tóth Boldizsár 
Published: July 2023

This academic contribution analyses the recent migration of a constitutional idea as a legal transplant in Central and Eastern Europe: the implementation of qualified law in several countries during their democratic transition. A cursory glance at the regional dimension of this constitutional instrument provides new insight into the role of qualified legislation during political transitions and leads to valuable experience regarding the migration of constitutional ideas in Central and Eastern Europe. It is demonstrated how the external, mainly Western European examples influenced the constitutional development of this region, and how the new democratic frameworks inspired each other within Central and Eastern Europe.
Serie de casos de sangrado intraluminal postoperatorio en colectomía izquierda.
Authors: Alaniz Alday Maria Jimena , Ramisch Diego A. , Bianchi Romina , Leiro Fabio , Gondolesi Gabriel 
Published: July 2023

Introducción: El sangrado digestivo post operatorio intraluminal es una entidad poco frecuente y su manifestación clínica no difiere de la hemorragia digestiva baja de otra etiología. A pesar de que su presentación más habitual es la hematoquecia autolimitada en la primera deposición, en un discreto porcentaje puede requerir transfusiones, tratamiento endoscópico, hemodinámico e incluso cirugía.
Objetivo: El objetivo de la siguiente presentación es analizar cuatro casos tratados en un centro de alta complejidad y realizar una revisión bibliográfica del tema.
Material y Métodos: Estudio retrospectivo descriptivo de pacientes con sangrado anastomótico durante el post operatorio inmediato de colectomía izquierda en el Servicio de Cirugía General y Coloproctología, desde enero del 2017 a diciembre del 2021. Contemplamos las variables: edad, sexo, anticoagulación y su causa, descenso de hemoglobina, cirugía realizada e indicación de la misma, abordaje, configuración de anastomosis, electividad de la cirugía, complicaciones, días de internación y manejo terapéutico.
Resultados: La incidencia según sexo fue de (1:1) y la edad media fue de de 72 años (rango 54- 87). A todos se les realizó una colectomía izquierda de forma programada y el abordaje fue laparoscópico en 3 casos (75%). En todos los casos se confeccionó una anastomosis termino-terminal con sutura mecánica circular. Todos los pacientes presentaron sangrado en las primeras 24 horas postoperatorias. El tratamiento fue decidido de acuerdo a la condición hemodinámica: En el 50% de los casos (n=2) que no presentaron inestabilidad hemodinámica, el tratamiento conservador con reanimación y transfusiones fue suficiente. Los 2 casos que presentaron inestabilidad hemodinámica requirieron manejo intervencionista con endoscopía rígida, video colonoscopia flexible y cirugía.
Conclusiones: El sangrado intraluminal es una complicación poco frecuente de la anastomosis colorrectal, requiriendo solo en un pequeño porcentaje tratamiento médico hasta incluso manejo intervencionista, sobre todo en los casos que se presentan con inestabilidad hemodinámica.
DONOR-ADVISED FUNDS IN THE WAKE OF THE TAX CUTS AND JOBS ACT
Authors: Walker David 
Published: July 2023

Donor-advised funds (DAFs) are conduits for charitable giving that support immediate tax deductions while creating a reservoir of assets for subsequent disposition to end-use charities. The number of new DAF accounts has skyrocketed in the wake of the 2017 Tax Cuts and Jobs Act (TCJA). This Article presents evidence suggesting that bunching charitable contributions to more fully exploit the TCJA-enhanced standard deduction likely motivates much of the onslaught of new DAF accounts established since 2016 and argues that the typical buncher is likely to differ from other DAF account holders in ways that matter from a policy perspective. Thus, while DAF critics have generally focused on the unproductive accumulation of assets in DAF accounts and have advanced reforms aimed at speeding up DAF payouts, this Article argues that in the context of bunchers, unproductive accumulation of assets in DAF accounts is unlikely to be a major problem. The more significant problem with DAF-facilitated bunching is that the cost to the public fisc is unlikely to be justified by incremental charitable giving. Thus, while this Article concludes that regulation targeting DAF payouts is unobjectionable, it argues that a wholly different set of reforms targeting the deductibility of charitable giving generally would be needed to address the cost of DAF-facilitated bunching under current law and under thoughtfully reformed laws involving universal charitable deductions above a floor.
Enseñanza y educación en pediatría basadas en simulación: un cambio de paradigma
Authors: Pleitez Navarrete Jorge Alberto 
Published: July 2023

David Gaba describía: «La simulación es una técnica, no una tecnología, para reemplazar o amplificar experiencias reales con experiencias guiadas que evocan o replican aspectos sustanciales del mundo real de una manera totalmente interactiva». En Pediatría, la enseñanza y educación con simulación fueron estudiadas por el grupo de la Universidad de Calgary, Canadá, quienes realizaron un metaanálisis con enfoque GRADE (Grados de recomendación, evaluación, desarrollo y evaluación) en el programa PALS (Pediatric Advanced Life Support) con el objetivo de comparar la efectividad de los maniquíes de alta versus baja fidelidad en el contexto del entrenamiento de soporte vital avanzado para mejorar el conocimiento y habilidades al finalizar el curso.
MUCINOSE ORAL FOCAL: RELATO DE CASO CLÍNICO
Authors: Queiroga Andréa Sarmento , De Lucena Cassiane Pereira , Bastos Maryana Marinho Barbosa , De Albuquerque Ana Carolina Lyra , De Carvalho Cyntia Helena Pereira , Do Nascimento George João Ferreira , De Figueiredo Claudia Roberta Leite Vieira , Barroso Keila Martha Amorim 
Published: July 2023

A Mucinose Oral Focal (MOF) é uma condição incomum, de origem desconhecida, representando a contraparte mucosa da Mucinose Focal Cutânea. O presente relato é de um paciente que procurou atendimento em uma Clínica-Escola de odontologia, relatando dificuldade de alimentação. Ao exame clínico, observou-se uma massa nodular, em mucosa rebordo alveolar maxilar do lado direito. Após realização de Biópsia do tipo excisional, realizou-se o exame histopatológico que demonstrou características de excessiva deposição de tecido conjuntivo mixomatoso vascularizado, de permeio a fibroblastos grandes, fusiforme e estrelados.
Embora seja difícil diagnosticar a MOF com base em sinais e sintomas clínicos a doença deve ser considerada uma possibilidade ao diagnosticar tumores orais benignos, especialmente quando localizados em gengiva e rebordo alveolar.
Implementasi UU No. 24 Tahun 2009 bagi Siswa-Siswi SMP Al Washliyah 8 Medan dengan Tema Bahasa Dunia Milenial
Authors: Kusyani Diah , Zahara Siti Fatimah , Muliatik Sri 
Published: July 2023

Mitra program Pengabdian Kepada Masyarakat adalah siswa-siswi SMP Alwashliyah 8 Medan. Di latar belakangi oleh generasi Milenial yang dewasa ini sedang viral, khususnya di media sosial. Netizen sering menyebutnya dengan kids jaman now. Generasi ini hadir sebagai bentuk diferensiasi antara generasi zaman dulu yang eksis di tahun 90-an dengan generasi yang sedang eksis di zaman sekarang. Dari segi usia, bisa dikatakan generasi milenial adalah mereka yang saat ini berada pada rentang umur 15-30 tahun. Sasaran utama dalam kegiatan ini adalah implementasi UU No. 24 Tahun 2009 bagi siswa-siswi di SMP Alwashliyah 8 Medan dengan tema “Bahasa Dunia Milenial”. Metode penyampaian dengan melakukan teknik game menggunakan apliaksi Kahoot dan ceramah yang dilakukan oleh dosen dan mahasiswa Program Studi Pendidikan Bahasa Indonesia FKIP Universitas Alwashliyah Medan. Hasil yang dicapai dari program pengabdian ini ialah (1) memperkenalkan Ejaan Bahasa yang Disempurnakan, (2) pengaruh bahasa gaul terhadap perkembangan Bahasa Indonesia, (3) Implementasi UU No. 24 Tahun 2009 melalui game aplikasi Kahoot, (4) memperkenalkan rasa cinta dan kesetiaan dalam berbahasa Indonesia. Pada kegiatan ini siswa-siswi sebagai mitra dikenalkan dengan identitas bahasa Indonesia sebagai jati diri bangsa sehingga para siswa sangat antusias bertanya dan terlihat sangat aktif menggunakan bahasa indonesia yang baik dan benar.
Nonlinear dynamics of interacting population in marine ecosystem with delay effect: model based study
Authors: Chatterjee Anal , Meng Weihua 
Published: July 2023

Abstract
In this paper, we propose a new tritrophic food chain model. We address the conditions for the coexistence of two different zooplankton species and one phytoplankton species. The results of the numerical and analytical studies of the model show that the most relevant parameters influencing the plankton ecosystem, to maintain a stable coexistence equilibrium, are the: carrying capacity and the constant intrinsic growth rate of the phytoplankton population, and the conversion rate with a mortality rate of carnivorous zooplankton. We prove the existence and direction of Hopf bifurcation in non delay system. To account for the time delay in the conversion of herbivorous consumption to carnivorous zooplankton, we incorporate a discrete delay into the consume response function. Furthermore, we establish some adequate conditions to prove the occurrence of Hopf bifurcation induced by delay in the delayed model. We also plot two-parameter bifurcation diagrams. The numerical results support the analytical findings.
Mathematics Subject Classification (2020) 92D40 · 92D25
Analysis of the Factors that Influence the Family in the Use of Traditional Medicine as Self Medication in Ilir Timur II District
Authors: Niza Hairun , Anwar Sarah Hanifah Az-Zahra , Wahyudi , 
Published: July 2023

Self-medication is a self-directed action in the application of both modern and traditional medicine. Traditional medicine has many benefits and its use is currently widespread due to its affordability and accessibility to the general public so it is widely used regularly even now. The increase in the use of traditional medicine globally makes people think it is always safe because it comes from plants. The purpose of this study was to determine the treatment profile, level of knowledge and factors that influence families in self-medication with traditional medicine. This study used descriptive analytic method with cross sectional design conducted in Ilir Timur II District, Palembang City. The results of the Chi-Square test found that the variables of gender (p-value 0.992), age (p-value 0.540), education (p-value 0.606), occupation (p-value 0.983), marital status (p-value 0.886), distance to health facilities (p-value 0.992), did not affect families in the use of traditional medicine as self-medication. A total of 98.6% have good knowledge about traditional medicine self-medication and there are no factors that influence the use of traditional medicine by families as self-medication.
Keywords: Self-medication, family, traditional medicine
Aktualne wyzwania dla wspólnej polityki rolnej
Authors: Stabryła-Chudzio Katarzyna 
Published: July 2023

W niniejszym artykule przedstawiono możliwości zmian we wspólnej polityce rolnej po 2013 roku. Zwrócono uwagę na propozycje Komisji Europejskiej będące efektem dyskusji z przedstawicielami wielu dziedzin i środowisk jak również na rezultaty badań innych instytucji. Celem opracowania było przybliżenie różnych stanowisk z położeniem szczególnego nacisku na toczące się negocjacje dotyczące wieloletnich ram finansowych na lata 2014 – 2020. Konieczność sprostania konkurencji państw z całego świata, a także zapewnienia bezpieczeństwa żywnościowego obywatelom Unii Europejskiej przy jednoczesnym poszanowaniu środowiska naturalnego i trosce o zdrowie roślin i zwierząt, należy zaliczyć do priorytetowych wyzwań dla przedstawicieli państw członkowskich UE.