bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational Modeling for Structural Elements Analysis Using Cement Composites in 3D Printing
Authors: Nóbrega Anna Christinna Secundo Lopes , Junior Cleanto Carlos de Queiroz , de Souza Wendell Rossine Medeiros , Cabral Kleber Cavalcanti , Martinelli Antônio Eduardo 
Published: April 2023

Abstract
The construction industry has incorporated 3D printing as an innovative technology. However, there are still challenges involving the complexity of the necessary parameters, such as the geometric characteristics, strength and rigidity of the printed objects. In this way, this study proposes a new computational modeling for dimensioning 3D printed structures, based on the non-linear mechanical properties of the material, that consists of a numerical reproduction of an experimental test using finite elements, with time interval between layers of 11s. The results obtained revealed good agreement with those from experimental tests, and consolidated the theoretical formulation. The parametric analyses showed that the proposed model is an accurate tool to reveal the effects of printing speed on the construction process in terms of vertical normal stress, with maximum percentage variation between the models of 5.22%, and in terms of vertical displacements, with variations smaller than 1 mm in absolute values.
A cost-effective operation specifically for pernicious placenta previa:Uterine tone-preserving bladder dissociation(UTBD)
Authors: Yang Feng , Xiong Meng , Zhou Daju , Liu Xiaohua , Li Shiqiong , Wu Qingrong , Qin Fengjiang 
Published: April 2023

Abstract
Objective:Pernicious placenta previa (PPP) is a special type of placenta previa, which emphasizes that the placenta attaches to the scar of the uterus [1], and has a high risk of placenta adhesion, implantation and fatal bleeding.PPP requires cesarean section to terminate pregnancy, often endangers the life of the parturient due to excessive bleeding during operation. Therefore, how to take effective measures to reduce bleeding during operation is the key to reduce the rate of hysterectomy and mortality.In order to solve this problem, we propose to apply a new surgical method--uterine tone-preserving bladder dissociation(UTBD) in cesarean section to provide better hemostatic effect.
Methods:The retrospective study was conducted on malignant placenta previa treated in Chongqing University Fuling Hospital from January 2016 to September 2022.During cesarean section, the patients who used uterine tone-preserving bladder dissociation were defined as the study group, and the patients who did not use the method were defined as the control group.The intraoperative blood loss, blood transfusion, operation time, hysterectomy, ICU occupancy rate and newborn birth of the two groups were counted.
Results: Total of 117 patients were screened out in this study, 54 of whom underwent cystectomy with uterine tension preservation during cesarean section, and 63 patients in the control group. During cesarean section, the use of bladder dissociation with preservation of uterine tension can significantly reduce intraoperative bleeding [700 (200~3800) vs 500 (300~2000)ml, p=0.001]; Blood transfusion volume significantly decreased [800 (100~3800) vs 600 (200~1200)ml, p=0.048], hysterectomy rate decreased (11.11% vs 0, p=0.033), and ICU occupancy rate decreased (14.29% vs 0, p=0.011). However, there was no statistical difference in the incidence of placental implantation (77.78% vs 85.19%, p=0.307), the probability of transfer to pediatrics (44.44% vs 39.62%, p=0.6) and the operation time[85 (43~290) vs 77.50 (40~160)min, p=0.082].
Conclusions:In the caesarean section of PPP patients, the use of uterine tone-preserving bladder distribution is simple to operate, can reduce intraoperative bleeding, maximize the retention of uterus, reduce the occupancy rate of ICU, improve the Apgar score of newborns, and does not increase the operation time. It is an effective and safe method targeting PPP.
Maximizing the extraction yield of plant gum exudate using response surface methodology and artificial neural networking and pharmacological characterization
Authors: Noureen Shazia , Noreen Sobia , Ghumman Shazia Akram , Al-Hussain Sami A , Hameed Huma , Anwar-Ul-Haq Muhammad , Irfan Ali , Batool Fozia , Hassan Muhammad Umair , Zaki Magdi E. A. , Aslam Samina 
Published: April 2023

Abstract
Prunus armeniaca gum is used as food additive and ethno medicinal purpose. Two empirical models RSM-CCD and ANN were used to search for optimized extraction parameters for gum extraction. A four-factor design was implemented for optimization of extraction process for maximum yield which was obtained under the optimized extraction parameter (temperature, pH, extraction time, and gum/water ratio). Micro and macro-elemental composition of gum was determined by using laser induced breakdown spectroscopy (LIBS). Gum was evaluated for toxicological effect and pharmacological properties. The maximum predicted yield obtained by RSM and ANN was 30.44 and 30.70% which was very close to maximum experimental yield 30.23%. LIBS spectra confirmed the presence Calcium, Potassium, Magnesium, Sodium, Lithium, Carbon, Hydrogen, Nitrogen and Oxygen. Acute oral toxicity study showed that gum is non-toxic up to 2000 mg/Kg body weight in rabbits, accompanied by high cytotoxic effects of PAG against HepG2 and MCF-7cells by MTT assay. Overall, Aqueous solution of PAG showed various pharmacological activities with significant value of antioxidant, antibacterial, anti-nociceptive, anti-cancer, anti-inflammatory and thrombolytic activities. Thus, optimization of parameters using mathematical models can offer better prediction and estimations with enhanced pharmacological properties of extracted components.
Evaluation of a DNA-based screening method for people at high risk of developing diabetes in the Dominican Republic
Authors: Glenda Borbón , Andrea Arreguín 
Published: April 2023

Abstract
Aim: This paper seeks to evaluate the significance of screening measures such as DNA tests in patients at risk of developing diabetes mellitus.
Methods:Patients at of high-risk (HR) and low-risk (LR) for developing diabetes mellitus (DM) according to risk factors established by the American Diabetes Association were divided into two groups, HR and LR. Both groups underwent nutrigenetic (PPARG, SLC2A2, TCF7L2, FTO genes), HOMA-IR score, and medical history screening. 26 patients were in the HR group and 38 were in the LR group.
Results:The mean age of participants in HR group was 47 (± 8.37) and 43 years (± 10.57) in the LR group, 69% of participants were male and 53% were female, respectively. In both groups, the mean of body mass index (BMI) was 27.3 (± 3.86) kg/m2. The PPARG, SLC2A2, TCF7L2, FTO genes showed some variation between HR and LR groups, but none reached statistical significance.
Conclusion:High risk individuals had an increased DM risk up to 3.7 times based on genetic variants of TCF7L2. Participants with genetic changes had up to 2.7 times higher than average risk for developing insulin resistance, but no statistical significance was obtained.
Modeling the Scaling Properties of Human Mobility in Virtual Space
Authors: Wang Mingyan , Zeng An , Cui Xiaohua 
Published: April 2023

Abstract
People are increasingly involved in online activities. Online activities can be regarded as movements in virtual space, such as jumping from webpage to webpage while surfing online, switching channels while watching TV, and browsing commodities while shopping online, which can affect information propagation, innovation spread, social activities, etc. Most previous efforts have been devoted to modeling the scaling properties of human mobility in physical space. Few studies aim to establish a unified and integral model to understand the fundamental dynamics underlying human virtual mobility. In this paper, we study human mobility in virtual space empirically and theoretically based on two datasets involving TV watching and online shopping and attempt to answer three unsolved issues. First, human virtual mobility shares common features, supported by the fact that striking agreements appear in the scaling properties of both datasets. Second, there exists a universal rule governing an individual's choice in virtual mobility, which is distinct from that in the real world due to travel restrictions. Third, there exists a unified model incorporating the behavior rule unique to virtual space under the framework of Exploration and Preferential Return, which can be used to reproduce the scaling properties of virtual mobility. We reveal the mechanism behind human virtual mobility through consistent scaling properties and develop a corresponding dynamic model based on empirical data.
The determinants of depression among the urban elderly: A study based on the Seoul Aging Survey, Korea
Authors: Shon Changwoo , Kim Junghyun 
Published: April 2023

Abstract
Purpose This study examines factors including sociodemographic characteristics, health behaviors, digital competency, and living environment on depression among the elderly in Seoul, Korea.Methods Drawn from the 2022 Seoul Aging Survey, 3,010 Seoulites aged 65 and older were selected. A multiple logistic regression analysis was conducted to determine the factors that contribute to depression among the urban elderly. The model included variables such as socioeconomic status, health status and health behaviors, digital competency, and cultural factors.Results It was found that food insecurity (OR: 2.89, p < .01) and the experience of unmet healthcare needs (OR: 2.89, p < .05) in urban elderly increased the prevalence of depression. As digital competency decreased, there was a corresponding increase in the prevalence of depression (OR: 2.61, p < .001). Also, as an environmental factor, the elderly who did not use cultural facilities had a statistically significant increase in the risk of depression (OR: 2.07, p < .05).Conclusions Findings suggest cities need to make political and practical efforts to secure food and nutrition, access to medical services, cultural facilities and strengthen digital capabilities in order to prevent depression among the urban elderly.
Extracellular vesicles of the probiotic E. coli O83 activate innate immunity and prevent allergy in mice
Authors: Schabussova Irma , Schmid Anna , Razim Agnieszka , Wysmolek Magdalena , Kerekes Daniela , Haunstetter Melissa , Kohl Paul , Brazhnikov Georgii , Geisler Nora , Thaler Michael , Krčmářová Eliska , Šindelář Martin , Hrdý Jiří , Schmidt Katy , Nejsum Peter , Whitehead Bradley , Palmfeldt Johan , Schild Stefan , –Kanada Aleksandra Inić , Wiedermann Ursula 
Published: April 2023

Abstract
E. coli O83 (Colinfant Newborn) is a Gram-negative probiotic bacterium used in the clinic. When administered orally, it reduces allergic sensitisation but not allergic asthma. Intranasal administration may be more effective as it reaches the lungs directly. Gram-negative bacteria release outer membrane vesicles (OMVs) to communicate with the environment. Here we investigate whether intranasally administered E. coli O83 OMVs (EcO83-OMVs) can reduce allergy in mice. EcO83-OMVs were isolated by ultracentrifugation and characterised for their number, morphology (shape and size), composition (proteins and lipopolysaccharide), recognition by innate receptors (using transfected HEK293 cells) and immunomodulatory potential (in naïve splenocytes and bone marrow-derived dendritic cells). Their allergy-preventive effect was investigated in a mouse model of allergic airway inflammation. EcO83-OMVs are spherical nanoparticles with a size of about 110 nm. They contain lipopolysaccharide and protein cargo. We identified a total of 1120 proteins, 136 of which were enriched in OMVs compared to the parent bacteria. Proteins from the flagellum dominated. OMVs activated the pattern recognition receptors TLR2/4/5 as well as NOD1 and NOD2. EcO83-OMVs were internalised by epithelial cells and induced the production of pro- and anti-inflammatory cytokines in splenocytes and bone marrow-derived dendritic cells. Intranasal administration of EcO83-OMVs inhibited airway hyperresponsiveness, decreased airway eosinophilia, Th2 cytokine production and mucus secretion. We show for the first time that intranasally administered OMVs from probiotic Gram-negative bacteria have an anti-allergic effect. Our study highlights the advantages of OMVs as a safe platform for the prophylactic treatment of allergies.
Do noncoding RNAs genes modulate PI3K/AKT signaling pathway in Polycystic ovary syndrome
Authors: Omar Heba S. , Ahmed Osama , Gomaa Maha , Faruk Eman , Fouad Hanan , Safwat Miriam 
Published: April 2023

Abstract
Background and aims: The PI3K protein kinase B (PI3K/Akt) signaling pathway has crucial roles in insulin signaling and other endocrine disorders. It is the purpose of this study to validate the association of PCOS with PI3K/AKT pathway target genes, miR486-5p, and miR483-5p as well as to evaluate the outcome of metformin on the pathogenesis of PCOS.
Methods: This case-controlled study included 3 subject groups: twenty healthy females (control group), twenty PCOS females before treatment, and twenty PCOS females treated with metformin at a dose (500 mg 3 times per day for three months). The following gene expressions were assessed by real-time PCR: PI3K, AKT, ERK, GLUT4, miR486-5p, and miR483-5p in the whole blood.
Result: There was a significant decrease in miR486-5p and miR483-5p in the PCOS group with a significant negative correlation between miR486-5p and PI3K and a significant negative correlation between miR483-5p and ERK. Metformin treatment resulted in significant elevation of the studied miRNAs, significant downregulation of PI3K/AKT target genes, and significant amelioration of the gonadotrophic hormonal imbalance and insulin resistance markers: fasting blood glucose, HBA1C, fasting insulin, and GLUT4 gene expression.
Conclusions: miRNA486 and miRNA483 downregulation may contribute to the etiology of PCOS, influence glucose metabolism, and result in IR in PCOS. Metformin's upregulation of those miRNAs affects glucose metabolism by controlling the expression of GLUT4, ameliorates PCOS-related insulin resistance, and improves PCOS-related hormonal imbalance by controlling the PI3K/AKT signaling pathway.
The Effect of Pumpkin Biscuits (Cucurbita moschata), Peanut (Arachis hypogaea) andMoringa Leaves (Moringa oleifera) on Hemoglobin Levels and Maternal Upper Arm Circumference (MUAC) of Pregnant Women
Authors: Sudaryati Etti , Panjaitan Arifa Masyita , Nadeak Tienne Artha Ulina , Tobing Andi MT Lumban , Masthalina Herta , Keloko Alam Bakti 
Published: April 2023

Abstract
Background : The cause of the problem of anaemia is a lack of intake of nutrients. Efforts made by the government to overcome this include the Supplemental Feeding Programme. The purpose of this study was to analyse the effect of additional food for pregnant women in the form of biscuits modified with pumpkin, moringa leaves, and peanuts on increasing haemoglobin levels and the size of the upper arm circumference in pregnant women as an effort to prevent stunting.
Methods: A quasi-experimental study (quasi-experimental design) with a non-group pretest-posttest design, namely comparing haemoglobin levels and upper arm circumference of pregnant women before and after the intervention. The intervention given was giving biscuits modified from moringa leaf flour, peanuts and pumpkin flour as much as 60 g (6 pieces) every day to pregnant women. Results : Modified biscuits contain 269.1 kcal of energy, 4.9% protein, 13.1% fat, 27.72% carbohydrates, vitamin C: 70.2 mg, and vitamin A: 6.2 mg. The average Hb level of pregnant women after the intervention was 11.5 g/dL, compared to 10.9 g/dL before the intervention. The average size of the upper arm circumference of pregnant women has also increased from 26.8 cm to 27.8 cm.
Conclusion: The modified biscuits meet the requirements of SNI biscuits and meet the requirements for PMT for pregnant women. Giving biscuits increased the average hemoglobin level of pregnant women by 0.82 g/dL and the average size of the upper arm circumference by 1.0 cm and reduced the prevalence of anemia in pregnant women by 60%.
Geriatric Onset of Attention-Deficit/Hyperactivity Disorder in a Patient with Comorbid Bipolar Disorder
Authors: Woods Joshua , Kiai Nakisa , Bangasan Rossano , Torrico Tyler 
Published: April 2023

Abstract
Background
An increasing number of adults over 60 years old are presenting with requests for treatment of attention-deficit/hyperactivity disorder (ADHD). However, the prevalence of ADHD in older adults in geriatrics is unknown. Further, comorbid bipolar disorder and adult ADHD are likely underrecognized with many patients only receiving treatment for one of these conditions. The occurrence of bipolar disorder with geriatric onset ADHD is unknown.
Case Presentation
A 64-year-old Hispanic woman with a psychiatric history of bipolar I disorder (diagnosed in early adulthood) was diagnosed with geriatric onset ADHD, and able to be successfully managed on concurrent mood stabilizers and psychostimulant medication.
Conclusions
The findings of this case report emphasize the importance of appropriately recognizing and treating comorbid ADHD and bipolar disorder in any age group, including the geriatric population for which this occurrence appears to be very rare. Additionally, this case report demonstrates the safe utilization of psychostimulant medications in a geriatric patient with bipolar disorder without inducing a manic episode or other significant adverse reactions.
Genetic and environmental architecture of synesthesia and its association with the autism spectrum - A twin study
Authors: Neufeld Janina , Taylor Mark , Leeuwen Tessa van , Kuja-Halkola Ralf , Lundström Sebastian , Larsson Henrik , Lichtenstein Paul , Bolte Sven 
Published: April 2023

Abstract
Synesthesia is a sensory phenomenon where external stimuli, such as music or letters, lead to additional sensations of, e.g., specific colors. Synesthesia aggregates in families and is more common in people on the autism spectrum compared to the general population.
We used classical twin design in order to assess the heritability of individual differences in synesthesia and the genetic and environmental contributions to their association with autistic traits.
Individual differences in synesthesia were estimated to be heritable and influenced by environmental factors not shared between twins. The autistic trait-domain of repetitive behaviors, restricted interests and attention to detail appeared to be driving the association between total autistic traits and synesthesia. The associations between individual differences in synesthesia and autistic traits was estimated to be mainly (>70%) under genetic influence.
In sum, synesthesia appears to be heritable and genetically linked to primarily non-social autistic trait domains.
Relativistic electron flux growth during storm and non-storm periods as observed by ARASE and GOES satellites
Authors: Belakhovsky Vladimir Borisovich , Pilipenko Vjacheslav , Antonova Elizaveta E. , Miyoshi Yoshizumi , Kasahara Yoshiya , Kasahara Satoshi , Higashio Nana , Shinohara Iku , Hori Tomoaki , Shoya Matsuda , Shoichiro Yokota , Takashima Takeshi , Takefumi Mitani , Keika Kunihiro , Nakamura Satoko 
Published: April 2023

Abstract
Variations of relativistic electron fluxes and wave activity in the Earth magnetosphere are studied in order to determine the contribution of different acceleration mechanisms of the outer radiation belt electrons: ULF mechanism, VLF mechanism, and adiabatic acceleration. The electron fluxes were measured by Arase satellite and geostationary GOES satellites. The ULF power index is used to characterize the wave activity of the magnetosphere in the Pc5 range. To characterize VLF wave activity in the magnetosphere, we use data from Arase satellite (PWE instrument). We consider strongest magnetic storms during the Arase satellite era: May 27-29, 2017; September 7-10, 2017; and August 25-28, 2018. Also, non-storm intervals with a high solar wind speed before and after these storms are considered as well. The magnitudes of relativistic electron fluxes during these magnetic storms (with an average solar wind speed) are found to be greater than that during non-storm intervals with a high solar wind streams. The substorm activity, as characterized AE index, is found to be a necessary condition for the increase of relativistic electron fluxes, whereas a high solar wind speed alone is not always necessary for the relativistic electron growth. The enhancement of relativistic electron fluxes by 1.5-2 orders of magnitude is observed 1-3 days after the ULF index growth and growth of the VLF radiation power. The analysis shows that the growth of VLF and ULF wave activity occurs approximately at the same time and coincides with the growth of substorm activity. Therefore, it is not easy to separate the contribution of these acceleration mechanisms over time. These mechanisms can act on a first phase of electron acceleration. During magnetic storms, the flux intensity maximum shifts to lower L-shells compared to intervals without magnetic storms. The acceleration mechanism associated with the injection of electrons into the region of the magnetic field weakened by the ring current and their subsequent betatron acceleration during the restoration of the magnetic field can work effectively at the second phase of electron acceleration.
The first direct measurements of ventilatory flow and oxygen utilization after exhaustive exercise and natural feeding in a teleost fish, Oncorhynchus mykiss
Authors: Eom Junho , Wood Chris M. 
Published: April 2023

Abstract
A new “less invasive” device incorporating an ultrasonic flow probe and a divided chamber, but no stitching of membranes to the fish, was employed to make the first direct measurements of ventilatory flow rate (V̇w) and % O2 utilization (%U) in juvenile rainbow trout (37 g, 8ºC) after exhaustive exercise (10-min chasing) and natural voluntary feeding (2.72% body mass ration). Under resting conditions, the allometrically scaled V̇w (300 ml kg−1 min−1 for a 37-g trout = 147 ml kg−1 min−1 for a 236-g trout exhibiting the same mass-specific O2 consumption rate, ṀO2) and the convection requirement for O2 (CR = 4.13 L mmol−1) were considerably lower, and the %U (67%) was considerably higher than in previous studies using surgically attached masks or the Fick principle. After exhaustive exercise, V̇w and ṀO2 approximately doubled whereas frequency (fr) and %U barely changed, so increased ventilatory stroke volume (Vsv) was the most important contributor to increased ṀO2. CR declined slightly. Values gradually returned to control conditions after 2–3 h. After voluntary feeding, short-term increases in V̇w, Vsv and ṀO2 were comparable to those after exercise, and fr again did not change. However, %U increased so CR declined even more. The initial peaks in V̇w, Vsv and ṀO2, similar to those after exercise, were likely influenced by the excitement and exercise component of natural feeding. However, in contrast to post-exercise fish, post-prandial fish exhibited second peaks in these same parameters at 1–3 h after feeding, and %U increased further, surpassing 85%, reflecting the true “specific dynamic action” response. We conclude that respiration in trout is much more efficient than previously believed.