bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the impact of Internet and media sources exposure on self-care behavior: mediating the role of health anxiety, literacy and information-seeking behavior
Authors: Soroya Saira Hanif , Rehman Adeel Ur , Faiola Anthony 
Published: August 2023

PurposeQuality of life is dependent on a healthy lifestyle and the self-care behavior of individuals. The study's purpose is to find out the determinants of individuals' self-care behavior. As such, self-care behavior is influenced by several factors that include individual knowledge, available information sources and their use, information-seeking related skills and cognitive state.Design/methodology/approachA quantitative research design followed using a questionnaire-based survey method. A total of 384 responses from the Pakistani public were collected using the convenience sampling technique. Structural equation modeling (SEM) was performed for examining the possible link between the variables.FindingsHealth literacy, Internet and social media use, and health information-seeking behavior had a direct/indirect positive impact on self-care behavior, but health anxiety had a negative impact. Health literacy and health information-seeking behavior positively mediated the relationship among Internet and social media use health anxiety and self-care.Research limitations/implicationsImproving health literacy appears to be key to supporting better self-care, but it is an exploratory study, more research is required to confirm these findings. Policymakers, health professionals and information professionals should work together to improve health literacy and support informed self-care among the population.Originality/valueThus far, no previous study has examined the collective role of social media exposure, health anxiety, health literacy and health information-seeking behavior as predictors of self-care behavior. Although self-care behavior among the general population might be different compared to chronic patients, only few studies have examined the former as a unit of analysis.
Cytocompatibility and cell migration evaluation of calcium silicate‐based root canal sealer compared to epoxide‐amine resin sealer in stem cells from human apical papilla: An in‐vitro study
Authors: Nguyen Linh Cao Hoai , Pham Loc Nguyen Gia , Van Pham Khoa , Nguyen Minh Duc , Ngo Lan Thi Quynh 
Published: August 2023

AbstractThe purpose of this study was to assess the effect of a calcium silicate‐based sealers (CeraSeal) and an epoxy resin‐based sealer (AH Plus) on cytotoxicity and cell migration of stem cell from the human apical papilla (hSCAPs) by using the Alamar Blue, Annexin V‐FICT and wound healing assays. In Alamar Blue assay, hSCAPs exposed to undiluted CeraSeal extract had significantly higher cell viability compared with that observed when cells were treated with AH Plus in all experimental period (p < 0.001). The flow cytometry analysis confirmed the comparison on viable cells and indicated that AH Plus increased apoptosis compared to CeraSeal and the control groups (p < 0.001). Additionally, AH Plus exhibited significantly lower level of cell migration than CeraSeal and the control for up to 48 h observation (p < 0.01). In summary, calcium silicate‐based sealer (CeraSeal) is less cytotoxic and more biocompatible than epoxy resin‐based sealer (AH Plus).
How safe is the treatment of pregnant women with fear of childbirth using eye movement desensitization and reprocessing therapy? Obstetric outcomes of a multi‐center randomized controlled trial
Authors: Baas Melanie A. M. , Stramrood Claire A. I. , Dijksman Lea M. , Vanhommerig Joost W. , de Jongh Ad , van Pampus Mariëlle G. 
Published: August 2023

AbstractIntroductionPregnant women with fear of childbirth display an elevated risk of a negative delivery experience, birth‐related post‐traumatic stress disorder, and adverse perinatal outcomes such as preterm birth, low birthweight, and postpartum depression. One of the therapies used to treat fear of childbirth is eye movement desensitization and reprocessing (EMDR) therapy. The purpose of the present study was to determine the obstetric safety and effectiveness of EMDR therapy applied to pregnant women with fear of childbirth.Material and methodsA randomized controlled trial (the OptiMUM‐study) was conducted in two teaching hospitals and five community midwifery practices in the Netherlands (www.trialregister.nl, NTR5122). Pregnant women (n = 141) with a gestational age between 8 and 20 weeks and suffering from fear of childbirth (i.e. sum score on the Wijma Delivery Expectations Questionnaire ≥85) were randomly allocated to either EMDR therapy (n = 70) or care‐as‐usual (CAU) (n = 71). Outcomes were maternal and neonatal outcomes and patient satisfaction with pregnancy and childbirth.ResultsA high percentage of cesarean sections (37.2%) were performed, which did not differ between groups. However, women in the EMDR therapy group proved seven times less likely to request an induction of labor without medical indication than women in the CAU group. There were no other significant differences between the groups in maternal or neonatal outcomes, satisfaction, or childbirth experience.ConclusionsEMDR therapy during pregnancy does not adversely affect pregnancy or the fetus. Therefore, therapists should not be reluctant to treat pregnant women with fear of childbirth using EMDR therapy.
Utilization and outcomes of V‐AV ECMO: A systematic review and meta‐analysis
Authors: Saxena Abhiraj , Curran John , Ahmad Danial , Nasher Nayeem , Miyamoto Takuma , Brailovsky Eugene , Shah Mahek K. , Rajapreyar Indranee N. , Rame J. Eduardo , Loforte Antonio , Entwistle John W. , Massey H. Todd , Tchantchaleishvili Vakhtang 
Published: August 2023

AbstractBackgroundVeno‐arterial–venous extracorporeal membrane oxygenation (V‐AV ECMO) is a less commonly used configuration of ECMO. We sought to understand the indications, utilization patterns, and outcomes of V‐AV ECMO by quantitatively pooling the existing evidence from the literature.MethodsElectronic search was performed to identify all relevant studies reporting V‐AV ECMO usage. Five studies comprising 77 patients were selected and cohort‐level data were extracted for further analysis.ResultsMean patient age was 61 (95% CI: 55.2, 66.5) years and 30% (23/77) were female. The majority of cases [91% (70/77)] were transitioned to V‐AV ECMO from another pre‐existing ECMO configuration: V‐A ECMO in 55% (42/77) vs. V‐V ECMO in 36% (28/77), p = 0.04. Only 9% (7/77) of cases were directly placed on V‐AV ECMO. The mean duration of hospital stay was 42.3 (95% CI: 10.5, 74.2) days, while ICU mortality was 46% (29, 64). Transition to durable left ventricular assist device was performed in 3% (2/64) of patients, while 3% (2/64) underwent heart transplantation. V‐AV ECMO was successfully weaned to explantation in 33% (21/64) of patients.ConclusionV‐AV ECMO is a viable option for optimizing cardiopulmonary support in selected patients. Survival to weaning or bridging therapy appears comparable to more common ECMO configurations.
A social emotional learning intervention to reduce psychosocial difficulties among rural children in central China
Authors: Li Jiameng , Hesketh Therese 
Published: August 2023

AbstractProgrammes based on social emotional learning (SEL) have been effective in reducing psychosocial difficulties in a number of countries. In Mainland China, there has been no empirical research on the prevention of children's psychosocial difficulties using the SEL approach. This study aimed to assess whether an adapted version of the SEL programme can reduce psychosocial difficulties of primary school children in rural China. The intervention consisted of 16 weekly 90‐min class sessions, conducted among 206 children aged 8–12 years (with 290 controls) in a poor rural area of Central China. Self‐report questionnaires were administered at baseline, post‐intervention and 5‐month follow‐up. The results suggested that the programme (1) can reduce children's total difficulties (measured using the Strength and Difficulties Questionnaire) at post‐intervention (d = −0.18) and 5‐month follow‐up (d = −0.19), (2) was more effective among children experiencing verbal abuse (d = −0.21) or physical abuse (d = −0.24) from caregivers and (3) was popular among more than 90% of the participants. The programme is cheap, easy to implement and can be delivered in school hours. Therefore, it has clear potential for replicability and sustainability.
Phase II trial of hypomethylating agent combined with nivolumab for acute myeloid leukaemia relapse after allogeneic haematopoietic cell transplantation—Immune signature correlates with response
Authors: Apostolova Petya , Kreutmair Stefanie , Toffalori Cristina , Punta Marco , Unger Susanne , Burk Ann‐Cathrin , Wehr Claudia , Maas‐Bauer Kristina , Melchinger Wolfgang , Haring Eileen , Hoefflin Rouven , Shoumariyeh Khalid , Hupfer Valerie , Lauer Eliza Maria , Duquesne Sandra , Lowinus Theresa , Gonzalo Núñez Nicolás , Alberti Chiara , da Costa Pereira Sara , Merten Carla Helena , Power Laura , Weiss Matthias , Böke Caroline , Pfeifer Dietmar , Marks Reinhard , Bertz Hartmut , Wäsch Ralph , Ihorst Gabriele , Gentner Bernhard , Duyster Justus , Boerries Melanie , Andrieux Geoffroy , Finke Juergen , Becher Burkhard , Vago Luca , Zeiser Robert 
Published: August 2023

SummaryAcute myeloid leukaemia (AML) relapse after allogeneic haematopoietic cell transplantation (allo‐HCT) is often driven by immune‐related mechanisms and associated with poor prognosis. Immune checkpoint inhibitors combined with hypomethylating agents (HMA) may restore or enhance the graft‐versus‐leukaemia effect. Still, data about using this combination regimen after allo‐HCT are limited. We conducted a prospective, phase II, open‐label, single‐arm study in which we treated patients with haematological AML relapse after allo‐HCT with HMA plus the anti‐PD‐1 antibody nivolumab. The response was correlated with DNA‐, RNA‐ and protein‐based single‐cell technology assessments to identify biomarkers associated with therapeutic efficacy. Sixteen patients received a median number of 2 (range 1–7) nivolumab applications. The overall response rate (CR/PR) at day 42 was 25%, and another 25% of the patients achieved stable disease. The median overall survival was 15.6 months. High‐parametric cytometry documented a higher frequency of activated (ICOS+, HLA‐DR+), low senescence (KLRG1−, CD57−) CD8+ effector T cells in responders. We confirmed these findings in a preclinical model. Single‐cell transcriptomics revealed a pro‐inflammatory rewiring of the expression profile of T and myeloid cells in responders. In summary, the study indicates that the post‐allo‐HCT HMA/nivolumab combination induces anti‐AML immune responses in selected patients and could be considered as a bridging approach to a second allo‐HCT.Trial‐registration: EudraCT‐No. 2017‐002194‐18.
Novel metallo‐β‐lactamases inhibitors restore the susceptibility of carbapenems to New Delhi metallo‐lactamase‐1 (NDM‐1)‐harbouring bacteria
Authors: Guo Yan , Liu Hongtao , Yang Mengge , Ding Rui , Gao Yawen , Niu Xiaodi , Deng Xuming , Wang Jianfeng , Feng Haihua , Qiu Jiazhang 
Published: August 2023

AbstractBackground and purposeThe production of metallo‐β‐lactamases is a major mechanisms adopted by bacterial pathogens to resist carbapenems. Repurposing approved drugs to restore the efficacy of carbapenems represents an efficient and cost‐effective approach to fight infections caused by carbapenem resistant pathogens.Experimental approachThe nitrocefin hydrolysis assay was employed to screen potential New Delhi metallo‐lactamase‐1 (NDM‐1) inhibitors from a commercially available U.S. Food and Drug Administration (FDA) approved drug library. The mechanism of inhibition was clarified by metal restoration, inductively coupled plasma mass spectrometry (ICP‐MS) and molecular dynamics simulation. The in vitro synergistic antibacterial effect of the identified inhibitors with meropenem was determined by the checkerboard minimum inhibitory concentration (MIC) assay, time‐dependent killing assay and combined disc test. Three mouse infection models were used to further evaluate the in vivo therapeutic efficacy of combined therapy.Key resultsTwelve FDA‐approved compounds were initially screened to inhibit the ability of NDM‐1 to hydrolyse nitrocefin. Among these compounds, dexrazoxane, embelin, candesartan cilexetil and nordihydroguaiaretic acid were demonstrated to inhibit all tested metallo‐β‐lactamases and showed an in vitro synergistic bactericidal effect with meropenem against metallo‐β‐lactamases‐producing bacteria. Dexrazoxane, embelin and candesartan cilexetil are metal ion chelating agents, while the inhibition of NDM‐1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM‐1. Furthermore, these four drugs dramatically rescued the treatment efficacy of meropenem in three infection models.Conclusions and implicationsOur observations indicated that dexrazoxane, embelin, candesartan cilexetil and nordihydroguaiaretic acid are promising carbapenem adjuvants against metallo‐β‐lactamases‐positive carbapenem resistant bacterial pathogens.
Responding to children's ambiguous loss in out‐of‐home care: The HEAR practice model
Authors: Kor Kenny , Park Jodie , Dear Rashelle , Fabrianesi Belinda 
Published: August 2023

AbstractChildren in out‐of‐home care may experience multiple losses, from separation from birth parents and siblings to loss of friendships, culture, and sense of belonging and normality. The impacts of these significant losses on a child's development and wellbeing have typically been the subject of childhood trauma research. While understanding the impact is important, children's experiences of the losses and the ways adults can support them to grieve are less explored in research. Recently, out‐of‐home care researchers have begun to address this knowledge gap by applying the concept of ambiguous loss to capture and understand children's grief and loss. This article builds on this work and reports findings of a qualitative study that involved 30 out‐of‐home care practitioners. Constructivist Grounded Theory was applied to analyse the research data which resulted in the HEAR model that outlines the practice components that out‐of‐home care practitioners considered important in effectively responding to children's experience of ambiguous loss. These components are (1) Honouring ambiguous loss; (2) Establishing a care community; (3) Attuning to the lack of finality of ambiguous loss and (4) Reducing ambiguity. This article presents research findings that supported the development of the HEAR model, and discusses its implications for out‐of‐home care practice.
Children's grief maps—Capturing children's grief and sorrow in family and close relationships
Authors: Pirskanen Henna 
Published: August 2023

AbstractTo better understand sensitive situations in children's lives, it is important to engage them in research. This article reports the initial findings of a study on children's grief. Grief map data were collected during interviews with 8‐ to 9‐year‐old children (N = 22). The aim was to explore children's perceptions of the family and close relationships that help them in moments of grief, and the relationships related to the cause of these emotions. The grief maps were analysed using content and thematic analyses. The results of the study demonstrate the deeply relational nature of children's grief.
Short‐term outcomes following total colectomy for inflammatory bowel disease in Denmark after implementation of laparoscopy: a nationwide population‐based study
Authors: Mark‐Christensen Anders , Troelsen Frederikke Schønfeldt , Tøttrup Anders , Nagy Dávid , Laurberg Søren , Erichsen Rune 
Published: August 2023

AbstractAimA laparoscopic approach to total colectomy (TC) for inflammatory bowel disease (IBD) is being increasingly used, but data on its comparative benefits over open TC are conflicting. The aim of this study was to examine 90‐day outcomes following laparoscopic and open TC for IBD in a nationwide cohort after the introduction of laparoscopy.MethodIBD patients undergoing TC in Denmark from 2005 to 2017 were identified from the Danish National Patient Registry. We used Kaplan–Meier methodology to estimate mortality and Cox regression analysis to estimate adjusted mortality rate ratios (aMRRs) and adjusted hazard ratios (aHRs) of reoperation, readmission and intensive care unit (ICU) transfer, comparing patients undergoing laparoscopic versus open TC.ResultsWe identified 1095 patients undergoing laparoscopic TC and 1523 patients undergoing open TC. Following emergency TC, 90‐day mortality was 2.8% (1.6%–4.9%) after laparoscopic TC and 9.1% (7.0%–11.8%) after open TC. Ninety‐day mortality was 0.9% (0.3%–2.5%) after laparoscopic TC and 2.6% (1.5%–4.3%) after open elective TC. The aMRRs associated with laparoscopic TC were 0.45 (95% CI 0.25–0.80) in emergency cases and 0.29 (95% CI 0.10–0.86) in elective cases. Risks of readmission were comparable following laparoscopic versus open TC, both in emergency [aHR = 0.93 (95% CI 0.76–1.15)] and elective [aHR = 0.83 (95% CI 0.68–1.02)] cases, while risks of ICU transfer and reoperation were lower following laparoscopic TC, both in emergency cases [aHR = 0.53 (95% CI 0.35–0.82) and aHR = 0.26 (95% CI 0.15–0.47)] and elective [aHR = 0.58 (95% CI 0.35–0.95) and aHR = 0.37 (95% CI 0.21–0.66)] cases.ConclusionThe introduction of laparoscopic TC for IBD in Denmark was not associated with increased mortality or morbidity. In fact, laparoscopic TC for IBD may be associated with lower short‐term mortality and morbidity compared with open TC.
Girls' schooling is important but insufficient to promote equality for boys and girls in childhood and across the life course
Authors: Desmond Chris , Watt Kathryn , Naicker Sara , Behrman Jere , Richter Linda 
Published: August 2023

AbstractMotivationInvesting in girls' schooling in low‐ and middle‐income countries (LMICs) is seen as central to improving gender equity. It is argued that interventions to promote girls' enrolment are appropriate as girls face gendered barriers to school enrolment and completion and investing in girls' schooling has high economic and human development returns. But is this fair to boys and enough for girls?PurposeWe ask how appropriate it is to direct development assistance towards improving girls' school enrolment, compared to prioritizing schooling for both girls and boys, and addressing barriers to gender equality throughout the life course.Methods and approachWe frame the enquiry through a human development framework with three distinct but interdependent domains: protection of human development potential; realization of human development potential; and use of human development potential.Using publicly available data, we identify indicators that are likely to be correlated with the degree to which human development potential is protected, realized, and utilized in LMICs. We compare male and female outcomes on each of these indicators to assess gender parity at different life stages.FindingsIn most regions, girls are ahead of boys in both school enrolment and completion. Girls have better outcomes than boys in several other indicators in early life and childhood.In adolescence and adulthood, girls and women fall behind boys and men. This is especially apparent in workforce participation, in unemployment, in pay, and in share of unpaid care work and political participation, where women have less favourable outcomes than men. The bias against women is most marked in South Asia and sub‐Saharan Africa.Policy implicationsA focus on girls' schooling should be tempered by ensuring quality pre‐primary, primary, and secondary schooling for both boys and girls. At the same time, we must address causes of gender inequality, including labour market discrimination and social norms that justify the exclusion and exploitation of women and girls.
Serum neurofilament light chain does not detect self‐reported treatment‐related fluctuations in chronic inflammatory demyelinating polyneuropathy
Authors: Poser Philip Lennart , Sajid Gulchan Shazadi , Beyer Léon , Hieke Alina , Schumacher Aurelian , Horstkemper Lea , Karl Anna‐Sophia , Grüter Thomas , Sgodzai Melissa , Pitarokoili Kalliopi , Gerwert Klaus , Gold Ralf , Fisse Anna Lena , Gisevius Barbara , Motte Jeremias 
Published: August 2023

AbstractIntroductionSerum neurofilament light chain (sNfL) is a marker for axonal degeneration. Patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) often report a fluctuation of symptoms throughout one treatment cycle with intravenous immunoglobulins (IVIG). The aim of this study was to determine whether sNfL is suitable to quantify patient‐reported symptom fluctuations.MethodsTwenty‐nine patients with the diagnosis of CIDP or a CIDP‐variant under treatment with IVIG were recruited in this study and underwent examination before IVIG infusion, in the middle of the treatment interval, and before their next IVIG infusion. Patients were surveyed regarding symptom fluctuations at the last visit and divided into two groups: those with and without fluctuations of symptoms. At the first visit, sociodemographic and disease‐specific data were collected. Clinical scores were assessed at every examination. sNfL values were compared between both groups at the different time points after conversion into Z‐scores—adjusted for age and body mass index.ResultsPatients with CIDP show elevated sNfL Z‐scores (median at baseline: 2.14, IQR: 1.0). There was no significant change in sNfL Z‐scores or questionnaire scores within the treatment cycle in either group. There was no significant difference in sNfL levels between the patients with and without symptom fluctuations.ConclusionsCIDP patients show elevated sNfL levels. However, sNfL is not suitable to reflect patient‐reported fluctuations of symptoms. This indicates that symptom fluctuations during treatment with IVIG in patients with CIDP are not caused by a neuroaxonal injury. Furthermore, repeated sNfL measurements within one treatment cycle with IVIG seem to have no benefit for symptom monitoring.
“The US is still more accepting and respecting of us”: Rethinking the “opt‐out” myth among highly educated Chinese immigrant stay‐at‐home mothers
Authors: Li Jialin 
Published: August 2023

AbstractScholars have long been fascinated by the push‐pull discourses that have been used to account for the work‐life (in)balance of college‐educated, stay‐at‐home mothers in the United States. However, the entire conversation about the opting‐out myth excludes the increasing population of highly educated, immigrant mothers. Meanwhile, international migration literature contends that highly educated, skilled, immigrant women experience an unexpected downward career mobility. However, among all the studies, the term motherhood and housewife are largely framed as a threat and source of frustration. In response to these two bodies of literature, I conducted semi‐structured interviews with 28 highly educated, Chinese stay‐at‐home mothers in the United States between August 2019 and July 2021. By adopting an intersectional lens, I argue that although the neoliberal, immigration structures have indeed caused career downward mobility among highly educated, Chinese immigrants, we should not assume that the current, new generation of Chinese women unanimously interprets full‐time motherhood simply as a disadvantage. Instead, I have found out that, due to social and cultural differences, these mothers all felt compelled to be stay‐at‐home immigrant mothers in the United States where they believe they would receive more respect and acceptance, and feel more liberation.