bluuebunny/crossref_metadata_2025_split huggingface dataset:
The first 10 years of simultaneous pancreas‐kidney transplantation in Finland
Authors: Ahopelto Kaisa , Sallinen Ville , Helanterä Ilkka , Bonsdorff Akseli , Grasberger Juulia , Beilmann‐Lehtonen Ines , Mäkisalo Heikki , Nordin Arno , Ortiz Fernanda , Savikko Johanna , Tukiainen Eija , Uutela Aki , Ekstrand Agneta , Lempinen Marko 
Published: April 2023

AbstractIntroductionSimultaneous pancreas‐kidney transplantation (SPK) is an option for patients with type 1 diabetes (T1D) and kidney failure but can be associated with a high complication rate. Here we describe our 10‐year experience since the launch of the SPK program.MethodsThis retrospective study included consecutive patients with T1D receiving SPK from March 14, 2010 to March 14, 2020 at Helsinki University Hospital. Portocaval anastomosis (i.e., systemic venous drainage) and enteric exocrine drainage were used. A specific team was trained for both pancreas retrieval and transplantation, postoperative care was standardized to include somatostatin analogues, antimicrobial treatment, and preoperatively initiated chemothrombopropylaxis. During program maturation donor criteria were expanded and logistical processes improved to minimize cold ischemia time. Clinical data were collected from a nationwide transplantation registry and patient records.ResultsA total of 166 SPKs were performed (median 2 per year in the first 3 years, 17.5 per year for the following 4 years, and 23 per year for the past 3 years). Seven patients (4.1%) died with a functioning graft with a median 43 months follow‐up. One‐year pancreas graft survival was 97.0%, 3‐year pancreas graft survival was 96.1% and 5‐year was 96.1%. Mean HbA1c was 36 mmol/mol (SD 5.57) and creatinine was 107 μmol/L (SD 34.69) at 1‐year after transplantation. All kidney grafts were functioning at the end of follow‐up. Complications required re‐laparotomy in 39 (23%) patients, mostly due to a pancreas graft related problem (N = 28). No pancreas or kidney graft failure from thrombosis occurred.ConclusionA planned, step‐wise development of an SPK program offers a safe and effective treatment for patients with T1D and kidney failure.
Impact of an artificial intelligence‐aided endoscopic diagnosis system on improving endoscopy quality for trainees in colonoscopy: Prospective, randomized, multicenter study
Authors: Yamaguchi Daisuke , Shimoda Ryo , Miyahara Koichi , Yukimoto Takahiro , Sakata Yasuhisa , Takamori Ayako , Mizuta Yumi , Fujimura Yutaro , Inoue Suma , Tomonaga Michito , Ogino Yuya , Eguchi Kohei , Ikeda Kei , Tanaka Yuichiro , Takedomi Hironobu , Hidaka Hidenori , Akutagawa Takashi , Tsuruoka Nanae , Noda Takahiro , Tsunada Seiji , Esaki Motohiro 
Published: April 2023

ObjectiveThis study was performed to evaluate whether the use of CAD EYE (Fujifilm, Tokyo, Japan) for colonoscopy improves colonoscopy quality in gastroenterology trainees.MethodsThe patients in this multicenter randomized controlled trial were divided into Group A (observation using CAD EYE) and Group B (standard observation). Six trainees performed colonoscopies using a back‐to‐back method in pairs with gastroenterology experts. The primary end‐point was the trainees' adenoma detection rate (ADR), and the secondary end‐points were the trainees' adenoma miss rate (AMR) and Assessment of Competency in Endoscopy (ACE) tool scores. Each trainee's learning curve was evaluated using a cumulative sum (CUSUM) control chart.ResultsWe analyzed data for 231 patients (Group A, n = 113; Group B, n = 118). The ADR was not significantly different between the two groups. Group A had a significantly lower AMR (25.6% vs. 38.6%, P = 0.033) and number of missed adenomas per patient (0.5 vs. 0.9, P = 0.004) than Group B. Group A also had significantly higher ACE tool scores for pathology identification (2.26 vs. 2.07, P = 0.030) and interpretation and identification of pathology location (2.18 vs. 2.00, P = 0.038). For the CUSUM learning curve, Group A showed a trend toward a lower number of cases of missed multiple adenomas by the six trainees.ConclusionCAD EYE did not improve ADR but decreased the AMR and improved the ability to accurately locate and identify colorectal adenomas. CAD EYE can be assumed to be beneficial for improving colonoscopy quality in gastroenterology trainees.Trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry (UMIN000044031).
MBRSDTC: Design of a multimodal bioinspired model to improve resource scheduling efficiency with differential task‐level constraints
Authors: Brahmam Madala Guru , Anand R. Vijay 
Published: April 2023

AbstractScheduling of resources in cloud environments requires design of multiple pattern analysis models that include but are not limited to, inter‐task dependency pattern analysis, make‐span pattern analysis, virtual machine (VM or resource) based capacity analysis, deadline analysis, and VM‐to‐task compatibility analysis. Existing scheduling models are either highly complex, or do not integrate comprehensive analysis modules for efficient scheduling of resources to tasks. Moreover, some of these models showcase limited scalability when applied to large‐scale deployment scenarios. To overcome these issues, this text proposes design of a multimodal bioinspired model to improve resource‐scheduling efficiency with differential task‐level constraints. The proposed model initially collects multimodal information sets about tasks and underlying resources in order to augment analysis efficiency for different task types. These information sets are initially processed by a Grey Wolf Optimization (GWO)‐based scheduling model that assists in grouping tasks based on their make‐span, deadline and dependency levels. The grouped tasks are then scheduled via an incremental learning Elephant Herding Optimization (EHO) model that assists in assigning grouped tasks to capacity‐tuned resources (or VMs). Due to integration of these optimization methods, the proposed model is capable of improving the efficiency of resource scheduling by 8.5%, while reducing computational complexity by 4.3%, while improving the deadline hit ratio by 5.9%, and lowering energy consumption by 1.5% when compared with standard machine learning based scheduling techniques. Due to which the proposed model is capable of deployment for a wide variety of real‐time scheduling scenarios.
Hyperspectral imaging for early diagnosis of diseases: A review
Authors: Mangotra Harshita , Srivastava Sahima , Jaiswal Garima , Rani Ritu , Sharma Arun 
Published: April 2023

AbstractHyperspectral Imaging (HSI) has grown to be one of the most crucial optical imaging modalities with applications in numerous industries. The non‐invasive nature of HSI has led to widening its horizon to the medical domain, especially in areas like early diagnosis of various diseases. HSI combines both imaging and spectroscopy properties, thereby exploiting spectral and spatial dimensions of images captured, providing quick and accurate interpretation of data. The current study aims to give an exhaustive overview of HSI's applications pertaining to the medical industry for fast detection of diseases and aiding in surgical procedures. The survey focuses on hyperspectral imaging combined with various approaches ‐ machine learning, deep learning, genetic algorithms, and anomaly detection for the treatment of disorders. In addition, the survey highlights accompanying pre‐processing approaches, performance metrics, inferences, and future prospects of HSI in the medical domain. The current study can gauge computer vision specialists, researchers in machine and deep learning domain, doctors, and scientists by giving them a platform for improving existing treatment methods for the betterment of society.
Trade‐offs between baseline thermal tolerance and thermal tolerance plasticity are much less common than it appears
Authors: Gunderson Alex R. 
Published: April 2023

AbstractThermal tolerance plasticity is a core mechanism by which organisms can mitigate the effects of climate change. As a result, there is a need to understand how variation in tolerance plasticity arises. The baseline tolerance/plasticity trade‐off hypothesis (hereafter referred to as the trade‐off hypothesis, TOH) has recently emerged as a potentially powerful explanation. The TOH posits that organisms with high baseline thermal tolerance have reduced thermal tolerance plasticity relative to those with low baseline tolerance. Many studies have found support for the TOH. However, this support must be regarded cautiously because the most common means of testing the TOH can yield spurious “trade‐offs” due to regression to the mean. I acquired data for 25 previously published analyses that supported the TOH at the intraspecific level and reanalyzed them after applying a method that adjusts plasticity estimates for regression to the mean. Only six of the 25 analyses remained statistically significant after adjustment, and effect size and variance explained decreased in all cases. The few data sets in which support for the TOH was maintained after adjustment point to areas of future study, but are too few to make generalizations at this point. In sum, regression to the mean has led to a substantial overestimation of support for the TOH and must be accounted for in future tests of the hypothesis.
Retracted publications in autism research are mostly concerned with ethical misconduct
Authors: Charbonneau Deborah H. , Ketcheson Leah R. 
Published: April 2023

AbstractBackgroundAs the prevalence of autism appears to increase, more research to guide effective diagnosis and intervention practices is needed. Findings disseminated through peer‐reviewed publications are critical, but the number of retractions continues to rise. An understanding of retracted publications is imperative to ensure the body of evidence is corrected and current.ObjectivesThe objectives of this analysis were to summarize key characteristics of retracted publications in autism research, examine the length of time between publication and retraction, and assess the extent journals are adhering to publishing ethical guidelines for reporting retracted articles.MethodsWe searched five databases through 2021 (PubMed, EMBASE, Scopus, Web of Science, and Retraction Watch).ResultsA total of 25 retracted articles were included in the analysis. Ethical misconduct accounted for the majority of retractions rather than scientific error. The shortest time to retraction was 2 months and the longest length was 144 months.DiscussionThe time lag between publication and retraction since 2018 has improved considerably. Nineteen of the articles had retraction notices (76%), whereas six articles did not have a notice (24%).ConclusionThese findings summarize errors of previous retractions and illuminate opportunities for researchers, journal publishers and librarians to learn from retracted publications.
Artificial intelligence adoption and system‐wide change
Authors: Agrawal Ajay , Gans Joshua S. , Goldfarb Avi 
Published: April 2023

AbstractAnalyses of artificial intelligence (AI) adoption focus on its adoption at the individual task level. What has received significantly less attention is how AI adoption is shaped by the fact that organizations are composed of many interacting tasks. AI adoption may, therefore, require system‐wide change, which is both a constraint and an opportunity. We provide the first formal analysis where multiple tasks may be part of an interdependent system. We find that reliance on AI, a prediction tool, increases decision variation, which, in turn, raises challenges if decisions across the organization interact. Reducing inter‐dependencies between decisions softens that impact and can facilitate AI adoption. However, it does this at the expense of synergies. By contrast, when there are mechanisms for inter‐decision coordination, AI adoption is enhanced when there are more inter‐dependencies. Consequently, we show that there are important cases where AI adoption will be enhanced when it can be adopted beyond tasks but as part of a designed organizational system.
Digital duplication of maxillary complete denture: A dental technique
Authors: Fekri Lina Khalaf , Abdelaziz Medhat Sameh 
Published: April 2023

AbstractObjectiveThis technique aims to construct a virtual, well‐adapted maxillary denture from an existing, ill‐fitting denture in completely edentulous patients.Clinical ConsiderationsA functional impression is made using the loose maxillary denture, and a cone beam computed tomography (CBCT) of the entire old denture is carried out. The obtained digital imaging and communication in medicine (DICOM) file was segmented using an image computing platform software (3D slicer). The resultant Standard Tessellation Language (STL) file was 3D printed in porcelain white‐like resin, then colored and characterized.ConclusionsThe technique introduces a high‐quality digital denture replicate with good retention, that can replace the traditional duplication technique. It can also be used as a relining method for old dentures. This proposed digital technique reduces the number of clinical appointments while also providing a digital library for future denture manufacture.Clinical SignificanceThe proposed technique offers a high‐quality digital denture replicate that can replace the traditional duplication technique. This digital technique also reduces the number of clinical appointments required for denture duplication.
Hematological and serum biochemistry evaluation in howler monkeys (Alouatta caraya) and capuchin monkeys (Sapajus apella): A comparative study
Authors: da Silva Gessiane Pereira , Pereira Thyago Habner de Souza , de Melo Josi Teixeira , Imbeloni Aline Amaral , Andrade Rafael do Santos de , Monteiro Maria Vivina Barros , Monteiro Frederico Ozanan Barros , Takeshita Rafaela S. C. 
Published: April 2023

AbstractBackgroundEvaluation of blood parameters in captive non‐human primates (NHPs) is crucial for monitoring their health and ensuring that their environment meets their physiological requirements.MethodsWe performed hemogram, serum biochemistry, and parasitological exams in 20 howler monkeys and 21 capuchin monkeys.ResultsIn both species, over 50% of the individuals presented at least one parasite. There was a negative effect of age on red blood cell (RBC), white blood cell, platelets, total protein, globulin, and alkaline phosphatase, and a positive effect on the A:G ratio, gamma‐glutamyl transferase, and mean platelet volume (MPV). Capuchin monkeys presented the highest platelets and alanine aminotransferase (ALT) values and howler monkeys presented the highest MPV, aspartate aminotransferase, ALT, amylase, glucose, bilirubin, and triglycerides values. We observed an interaction between species and sex on RBC, Htc, mean corpuscular hemoglobin concentration, and cholesterol.ConclusionsSpecies differences found in blood parameters may reflect differences in physiological adaptations associated with ecological and morphological traits and are clinically relevant for evaluating animal health and the suitability of breeding programs.
Impact of temporomandibular disorders on oral health‐related quality of life: A systematic review and meta‐analysis
Authors: Qamar Zeeshan , Alghamdi Ahmed Mohammed Saad , Haydarah Naji Khaled Bin , Balateef Abdulateef Ahmed , Alamoudi Ahmed Aydhah , Abumismar Munther Amer , Shivakumar Sahana , Cicciù Marco , Minervini Giuseppe 
Published: April 2023

AbstractBackgroundThe management of temporomandibular disorders (TMDs) requires a comprehensive approach that considers multiple factors, including the impact of oral health‐related quality of life (OHRQoL). Through this investigation we aim to assess the impact of OHRQoL played in a TMD‐afflicted individual.MethodsUsing keywords relevant to our research, such as “Oral health related quality of life,” “Oral hygiene,” “Temporomandibular joint” and “Temporomandibular disorders,” a comprehensive search across multiple online databases was carried out, yielding a total of 632 studies at the preliminary stage of the review. Modified New Castle Ottawa scale was used to assess the quality of studies included.ResultsEight studies were included in the review, out of which six were eligible for further meta‐analysis. The studies included in this review employed various OHRQoL measures, including the Oral Health Impact Profile—14 (OHIP—14), the Short‐Form 36 Health Survey (SF‐36) and the OHIP‐ 49. All the studies demonstrated significant effect of TMDs on the OHRQoL of the target population under study.ConclusionThe impact of OHRQoL on the management of TMD was deemed to be significant. The comprehensive management of TMD should consider the impact of the condition on the individual's daily life and incorporate interventions that address both the physical and psychological aspects of the condition. By improving OqL, individuals with TMD can experience improved overall well‐being and quality of life.
Urinary liver‐type fatty acid binding protein is increased in the early stages of the disease with a risk of acute kidney injury induced by histone
Authors: Ohata Keiichi , Sugaya Takeshi , Nguyen Hanh Nhung , Hatanaka Yuri , Uno Kinuko , Tohma Marika , Oikawa Tsuyoshi , Nagabukuro Hiroshi , Kuniyeda Kanako , Kamijo‐Ikemori Atsuko , Suzuki‐Kemuriyama Noriko , Nakae Dai , Noiri Eisei , Miyajima Katsuhiro 
Published: April 2023

AbstractAimUrinary liver‐type fatty acid binding protein (L‐FABP) has potential utility as an early prognostic biomarker ahead of traditional severity scores in coronavirus disease 2019 and sepsis, however, the mechanism of elevated urinary L‐FABP in the disease has not been clearly elucidated. We investigated the background mechanisms of urinary L‐FABP excretion through non‐clinical animal model focusing on histone, which is one of the aggravating factors in these infectious diseases.MethodsMale Sprague–Dawley rats were placed in central intravenous catheters, and these rats were given a continuous intravenous infusion of 0.25 or 0.5 mg/kg/min calf thymus histones for 240 min from caudal vena cava.ResultsAfter the administration of histone, urinary L‐FABP and gene expression of an oxidative stress marker in the kidney increased in a histone dose‐dependent manner before increased serum creatinine. Upon further investigation, fibrin deposition in the glomerulus was observed and it tended to be remarkable in the high dose administrated groups. The levels of coagulation factor were significantly changed after the administration of histone, and these were significantly correlated with the levels of urinary L‐FABP.ConclusionsFirstly, it was suggested that histone is one of the causative agents for the urinary L‐FABP increase at an early stage of the disease with a risk of acute kidney injury. Secondly, urinary L‐FABP could be a marker reflecting the changes of coagulation system and microthrombus caused by histone in the early stage of acute kidney injury before becoming severely ill and maybe a guide to early treatment initiation.
Barriers and facilitators to resilience for rural cancer survivors during COVID‐19
Authors: Bernacchi Veronica , LeBaron Virginia , Porter Kathleen , Zoellner Jamie , DeGuzman Pam 
Published: April 2023

AbstractThe purpose of this study was to identify the barriers and facilitators of resilience for rural cancer survivors during COVID‐19. A descriptive qualitative study design was used to achieve the study objected. We recruited six posttreatment cancer survivors, four caregivers of cancer survivors, and one survivor who also identified as a caregiver, all from rural Southwest Virginia. Participants completed 60–90 minute virtual interviews that were recorded, transcribed, and verified in Dedoose qualitative software. Data was analyzed using an inductive and deductive coding strategies, and thematic analysis was used to develop key themes. Four key themes emerged from the data: 1) Religious faith is a primary source of resilience, 2) Spiritual cancer care strengthens resilience, 3) Virtual platforms provide critical connections to faith communities, and 4) Fearful and fatalistic cancer beliefs reduce resilience. The findings provide critical descriptive evidence that faith facilitates resilience for rural cancer survivors, while rural cultural norms of fearful and fatalistic cancer beliefs reduce resilience. In the context of COVID‐19, rural survivors prioritize utilizing virtual support groups to strengthen their resilience. Nurses should incorporate a spiritual assessment into survivorship care, and guide survivors to existing virtual support groups.
Offset or reduce: How should firms implement carbon footprint reduction initiatives?
Authors: Roemer Nils , Souza Gilvan C. , Tröster Christian , Voigt Guido 
Published: April 2023

Carbon emissions reduction initiatives have received considerable attention at the corporate level. Companies such as Daimler, Apple, and Amazon have publicly declared their goal of becoming carbon neutral or “net zero” in a near future. They are responding to a growing demand for sustainable products and services. Companies have a variety of options for carbon emission reductions available to them, including internal reductions such as adopting renewable energy as well as buying carbon offsets. This raises the question of whether consumers perceive the different types of carbon emission reductions as equivalent, or whether they favor the implementation of internal measures. We investigate this issue empirically through surveys and incentive‐compatible discrete choice experiments. We find clear consumer preferences and willingness to pay for companies to reduce their carbon footprint when companies internally reduce their controllable emissions rather than buying carbon offsets for these emissions, and it is especially true for eco‐conscious consumers. Consumers place roughly the same value, however, on internal reductions in controllable emissions and buying offsets for the same amount of uncontrollable emissions.
HOS1 promotes plant tolerance to low‐energy stress via the SnRK1 protein kinase
Authors: Margalha Leonor , Elias Alexandre , Belda‐Palazón Borja , Peixoto Bruno , Confraria Ana , Baena‐González Elena 
Published: April 2023

SUMMARYPlants need to integrate internal and environmental signals to mount adequate stress responses. The NUCLEAR PORE COMPLEX (NPC) component HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 (HOS1) is emerging as such an integrator, affecting responses to cold, heat, light, and salinity. Stress conditions often converge in a low‐energy signal that activates SUCROSE NON‐FERMENTING 1‐RELATED KINASE 1 (SnRK1) to promote stress tolerance and survival. Here, we explored the role of HOS1 in the SnRK1‐dependent response to low‐energy stress in Arabidopsis thaliana, using darkness as a treatment and a combination of genetic, biochemical, and phenotypic assays. We show that the induction of starvation genes and plant tolerance to prolonged darkness are defective in the hos1 mutant. HOS1 interacts physically with the SnRK1α1 catalytic subunit in yeast two‐hybrid assays and in planta, and the nuclear accumulation of SnRK1α1 is reduced in the hos1 mutant. Likewise, another NPC mutant, nup160, exhibits lower activation of starvation genes and decreased tolerance to prolonged darkness. Importantly, defects in low‐energy responses in the hos1 background are rescued by fusing SnRK1α1 to a potent nuclear localization signal or by sugar supplementation during the dark treatment. Altogether, this work demonstrates the importance of HOS1 for the nuclear accumulation of SnRK1α1, which is key for plant tolerance to low‐energy conditions.