bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extraction of phospholipids from beta‐serum using switchable solvents and solid‐phase extraction
Authors: Rathnakumar Kaavya , Ortega‐Anaya Joana , Jimenez‐Flores Rafael , Martínez‐Monteagudo Sergio I. 
Published: June 2023

AbstractWe report the extraction of milk phospholipids (MPLs) from beta‐serum with a tertiary amine (N‐N dimethylcyclohexylamine, CyNMe2). The extraction time (3, 10, and 18 h), temperature (25, 40, and 60°C), and sample‐to‐solvent ratio (1/3, 1/10, and 1/18 v/v) were evaluated according to a factorial design. The extracted lipids were fractionated with solid‐phase extraction and quantified by HPLC‐CAD. Extraction conducted at 60°C yielded values of 14.86 ± 2.95%, 69.79 ± 3.19%, 79.39 ± 5.55% after 3, 10, and 18 h and a ratio of 1/18 (w/w). Microstructure images showed significant damage to the solid matrix that released the inner MPLs into the aqueous medium. The highest extraction yields of MPLs (79.39 ± 5.55%) were obtained after 18 h of extraction at 60°C and a sample‐to‐solvent ratio of 18 (w/w). The recovered fraction was made of phosphatidylinositol (~41%), phosphatidylserine (~6%), phosphatidylethanolamine (~34%), phosphatidylcholine (~9%), and sphingomyelin (~8%). This work outlines different extraction conditions for recovering MPLs from beta‐serum, a dairy byproduct.
Preparation and mechanical properties of graphite nanosheet/nylon 610 nanocomposites using graphite nanosheets treated with supercritical water
Authors: Lim Jun‐Ven , Bee Soo‐Tueen , Sin Lee Tin , Ratnam Chantara Thevy , Bee Soo‐Ling 
Published: June 2023

AbstractIn this study, water at high temperature (175°C) and in vacuum state (−1 bar) is applied to graphite nanosheets to enhance surface activity through the formation of oxygen functionalities via supercritical water treatment. The nylon 610 nanocomposites (with treated or untreated nanosheets as nanofillers) was then synthesized using interfacial polymerization. X‐ray diffraction (XRD) analysis showed that the water treatment had not altered the crystal structure of the graphite nanosheets. On average, the Young's modulus and tensile strength of the nanocomposites are larger than the pure nylon 610 created, with the highest Young's modulus and tensile strength obtained being 137.44 MPa and 930.49 kPa, respectively. The tensile strength of treated nanosheets/nylon nanocomposites generally decreased with increasing wt%; while, that of untreated nanosheets/nylon nanocomposites increased with increasing wt%. This enhancement in mechanical properties can be attributed to the functionalization of graphite nanosheets, which may yield a slight oxidation on its surface, allowing for stronger interaction between the nylon 610 matrix and the nanosheets. Fourier transform infrared (FTIR) spectra also showed the presence of hydrogen bonding between the carbon nanofillers and the polymer matrix through the appearance of amide bands. Furthermore, scanning electron microscopy (SEM) showed that at higher wt%, aggregation will occur, which may lead to a weakening in physical properties. Nevertheless, this improvement in mechanical properties when compared with pure nylon 610 can be attributed to the intact structure of the nanosheets and the chemical bonding between the nanofillers and nylon 610.
Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review
Authors: Etter Emily , Bosse Benjamin , Wang Yi Peng , Hiniker Susan , Oh Justin 
Published: June 2023

Key Clinical MessageLangerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm arising from the proliferation of pathologic Langerhans cells. LCH has a spectrum of presentations predominantly affecting male pediatric patients. As LCH is a relatively uncommon diagnosis, there is no standard of care for treatment of the disease and treatment is based largely on clinical judgment, lesion characteristics, and symptoms at presentation. Here we present a case of unifocal, isolated orbital LCH in a 19‐year‐old young man treated initially with surgical resection. Follow‐up imaging 2 months later demonstrated significant regrowth of the mass and no other sites of disease. The recurrent orbital disease was treated with stereotactic radiosurgery (SRS) to 7 Gy in one fraction. Near complete resolution of the mass was achieved with no recurrence after 1.5 years of follow‐up. SRS for treatment of orbital LCH is a novel treatment not previously described in the literature which may provide benefit in select cases.
Recurrent bicycle falls by an elderly man who developed multiple intramuscular abscesses associated with urine leakage secondary to posterior urethral injury caused by pelvic ring disruption
Authors: Matsumoto Yoko , Tanno Keisuke , Nakamura Yuhei , Hamamoto Kohei , Yoshihara Hanako , Fukuchi Takahiko , Oyama‐Manabe Noriko , Sugawara Hitoshi 
Published: June 2023

Key Clinical MessageWith the aging of the population, physicians need to pay more attention to assessing the presence or absence of pelvic fractures and urinary retention associated with urethral injury due to such fractures in the elderly when falling from bicycles.AbstractWalking ability does not rule out the presence of pelvic fractures. Many geriatric patients are likely to fall off bicycles. Physicians should pay more attention when assessing complications related to urethral trauma caused by pelvic fractures in the elderly after falling from bicycles.
Crystal Structure and Photocatalytic Properties of the CsV0.625Te1.375O6 Mixed‐Valence β‐Pyrochlore Compound
Authors: Fukina Diana G. , Shotina Valeria A. , Boryakov Aleksey V. , Zubkov Sergey Yu. , Telegin Sergey V. , Volkova Natalia S. , Fukin Georgy K. , Shilova Elena V. , Suleimanov Evgeny V. 
Published: June 2023

AbstractA new β‐pyrochlore compound with complex composition of Cs(V3+0.0625V5+0.5625Te4+0.34375Te6+1.03125)O6 has been synthesized by a solid‐state reaction and characterized by single‐crystal X‐ray diffraction and thermal analysis. The compound possesses the typical cubic symmetry with space group
, however some of the oxygen atoms shift from the special position 48 f to the general crystallographic positions 32e, 96 g and 96 h. This shift is caused by complex B‐site composition with mixed‐valence vanadium and tellurium atoms, especially the presence of the large Te4+ ion. The locations of the valence band and conduction band edges were determined experimentally under vacuum conditions by X‐ray photoelectron spectroscopy, UV‐visible and impedance spectroscopy and evaluated theoretically for water solutions. The photocatalytic ability of the compound under visible light irradiation was determined using the methylene blue decomposition process as an example. The nature of the active radical species and possible dye degradation pathway were suggested according to experimental data.
Protocol of the Double‐Click Seq Method to Evaluate the Deposition Bias of Chromatin Proteins
Authors: van der Wouden Petra E. , Zwinderman Martijn R. H. , Chen Deng , Borghesan Michela , Dekker Frank J. 
Published: June 2023

AbstractSymmetrical deposition of parental and newly synthesized chromatin proteins over both sister chromatids is important for the maintenance of epigenetic integrity. However, the mechanisms to maintain equal distribution of parental and newly synthesized chromatid proteins over sister chromatids remains largely unknown. Here, we describe the protocol for the recently developed double‐click seq method that enables mapping of asymmetry in the deposition of parental and newly synthesized chromatin proteins on both sister chromatids in DNA replication. The method involved metabolic labeling of new chromatin proteins with l‐Azidohomoalanine (AHA) and newly synthesized DNA with Ethynyl‐2′‐deoxyuridine (EdU) followed by two subsequent click reactions for biotinylation and subsequently by corresponding separation steps. This enables isolation of parental DNA that was bound to nucleosomes containing new chromatin proteins. Sequencing of these DNA samples and mapping around origins of replication in the cellular DNA enables estimation of the asymmetry in deposition of chromatin proteins over the leading and lagging strand in DNA replication. Altogether, this method contributes to the toolbox to understand histone deposition in DNA replication. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Metabolic labeling with AHA and EdU and isolation of nucleiBasic Protocol 2: First click reaction, MNase digestion and streptavidin enrichment of labeled nucleosomesBasic Protocol 3: Second click reaction, Replication‐Enriched Nucleosome Sequencing (RENS) Protocol
Fusion of artificial intelligence and game theory for resource allocation in non‐orthogonal multiple access‐assisted device‐to‐device cooperative communication
Authors: Rathod Tejal , Gupta Rajesh , Kumar Jadav Nilesh , Tanwar Sudeep , Alabdulatif Abdulatif , Sharma Ravi 
Published: June 2023

SummaryDevice‐to‐device (D2D) communication offers a low‐cost paradigm where two devices in close proximity can communicate without needing a base station (BS). It significantly improves radio resource allocation, channel gain, communication latency, and energy efficiency and offers cooperative communication to enhance the weak user's network coverage. The cellular mobile users (CMUs) share the spectral resources (e.g., power, channel, and spectrum) with D2D mobile users (DMUs), improving spectral efficiency. However, the reuse of radio resources causes various interferences, such as intercell and intracell interference, that degrade the performance of overall D2D communication. To overcome the aforementioned issues, this paper presents a fusion of AI and coalition game for secure resource allocation in non‐orthogonal multiple access (NOMA)‐based cooperative D2D communication. Here, NOMA uses the successive interference cancellation (SIC) technique to reduce the severe impact of interference from the D2D systems. Further, we utilized a coalition game theoretic model that efficiently and securely allocates the resources between CMUs and DMUs. However, in the coalition game, all DMUs participate in obtaining resources from CMUs, which increases the computational overhead of the overall system. For that, we employ artificial intelligence (AI) classifiers that bifurcate the DMUs based on their channel quality parameters, such as reference signal received power (RSRP), received signal strength indicator (RSSI), signal‐to‐noise ratio (SNR), and channel quality indicator (CQI). It only forwards the DMUs that have better channel quality parameters into the coalition game, thus reducing the computational overhead of the overall D2D communication. The performance of the proposed scheme is evaluated using various statistical metrics, for example, precision score, accuracy, recall, F1 score, overall sum rate, and secrecy capacity, where an accuracy of 99.38% is achieved while selecting DMUs for D2D communication.
Ecological momentary assessment of mood regulation eating expectancies in eating disorders: Convergent and predictive validity
Authors: Mason Tyler B. , Crosby Ross D. , Engel Scott G. , Morales Jeremy C. , Wonderlich Stephen A. 
Published: June 2023

AbstractObjectiveEating expectancies (EE) are the anticipation of various benefits or detriments from eating, with mood regulation being a salient type of EE associated with eating disorders. This study examined the convergent and predictive validity of ecological momentary assessment (EMA) mood regulation EE items, including mood improvement and mood worsening EE.MethodsThirty women with binge‐eating pathology completed a 14‐day EMA protocol, which included measures of mood regulation EE, affect, appetite, appearance‐ and body‐related factors and disordered‐eating behaviours.ResultsGreater within‐subjects hunger and lower within‐subjects positive affect and fullness were related to elevated mood improvement EE. Higher within‐subjects appearance concerns, fullness, body social comparisons and thinness pressure were associated with higher mood worsening EE. Greater within‐subjects mood worsening EE predicted greater likelihood of vomiting at the subsequent time point, but there were no within‐subjects associations between mood improvement EE and behaviours. Yet, greater between‐subjects mood worsening EE were associated with more restraint/restriction and binge eating, and greater between‐subjects mood improvement EE were associated with more binge eating.ConclusionsFindings support the convergent validity of EMA mood regulation EE items. There was limited predictive validity evidence, suggesting complexities in how mood regulation EE predict behaviour in daily life.
An intensive longitudinal investigation of maternal and infant touching patterns across context and throughout the first 9‐months of life
Authors: Mercuri Marisa , Stack Dale M. , De France Kalee , Jean Amélie D. L. , Fogel Alan 
Published: June 2023

AbstractTouch is a central component of mothers’ and infants’ everyday interactions and the formation of a healthy mother‐infant relationship. Twelve mothers and their full‐term infants from the Midwest, USA participated in the present study, which examined the quality and quantity of their touching behaviors longitudinally at 1‐, 3‐, 5‐, 7‐, and 9‐months postpartum and within two normative interaction contexts (face‐to‐face, floor play). Findings revealed that mothers’ and infants’ individual touch patterns, varied according to context, infant age (time), and the specific type of touch examined. At 1‐month postpartum, dyads coordinated their touch via behavioral matching and were especially reliant on rudimentary types of touch with soothing and regulatory properties (static/motionless touch, stroking). As infants aged to 9‐months, dyads transitioned to a more complex form of tactile synchrony characterized by the parallel use of complementary types of touch (grasp, poke, pull). This evolution of tactile synchrony may reflect infants’ growing behavioral repertoire and increased capacity to use more refined forms of touch. To our knowledge, this study was the first of its kind, uniquely contributing to the scant knowledge about the development of mother‐infant touch and synchrony and offering direct implications for early care practices and infant health and well‐being.
Adaptive 3D noise level‐guided restoration network for low‐dose positron emission tomography imaging
Authors: Li Wenbo , Huang Zhenxing , Zhou Chao , Zhang Xu , Fan Wei , Liang Dong , Hu Zhanli 
Published: June 2023

AbstractMany deep learning methods have been proposed to improve the quality of low‐dose PET images (LPET), which usually construct end‐to‐end networks with certain radiation dose inputs. However, these approaches have omitted the noise disparity in PET images, which may differ among manufacturers or populations. Therefore, we tend to exploit these noise differences among PET images to achieve adaptive restoration. We proposed a 3D noise level‐guided PET restoration network for LPET including (1) adaptive noise level‐aware subnetwork and (2) LPET restoration subnetwork. The first subnetwork aims to predict the noise level of the given LPET, while the second subnetwork treats the estimated noise level as a priori information to guide the restoration process from LPET to standard‐dose PET images. Experiments were performed on real human head and neck datasets while the peak signal‐to‐noise ratio and structural similarity index measure were used to evaluate LPET recovery performance. Moreover, we also compared the proposed network with several deep‐learning approaches. Experimental results demonstrate that our network with dual‐stage design can perform adaptive restoration for LPET, yielding better visual and quantitative results. In future work, we attempt to apply our method to other imaging tasks and adapt it for clinical practice.
Identification of a novel cuproptosis‐related gene signature for rheumatoid arthritis—A prospective study
Authors: Hu Han , Dou Xinyu , Hu Xiangjia , Wang Linbang , Ma Yunlong , Liu Jingkun , Zhou Xuchang , Cao Hong , Liu Xiaoguang , Deng Xiaoming , Li Nan 
Published: June 2023

AbstractBackgroundRheumatoid arthritis (RA) is a multifactorial systemic autoimmune disease characterized by ongoing synovial inflammation, leading to the degradation of cartilage. Cuproptosis, as a newly characterized form of cell death, may influence RA progression by regulating immune cells and chondrocytes. This study sets out to identify the hub cuproptosis‐related gene (CRG) associated with the pathogenesis of RA.MethodsA series of bioinformatic analyses were performed to evaluate the expression score of CRGs and the immune infiltration landscape between RA and normal samples. The hub gene was screened through the correlation analysis of CRGs, and the interaction network between the hub gene and transcription factors (TFs) was constructed. Finally, the hub gene was validated through quantitative real‐time polymerase chain reaction (qRT‐PCR) of patient samples and cell experiments.ResultsDrolipoamide S‐acetyltransferase (DLAT) was screened as the hub gene. Correlation analysis between the hub gene and immune microenvironment demonstrated that DLAT had the highest correlation with T follicular helper cells. Eight pairs of DLAT–TF interaction networks were constructed. Single‐cell sequencing showed that CRGs were highly expressed in RA chondrocytes, and chondrocytes could be classified into three different subsets. qRT‐PCR was used to validate the above results. Dlat knockdown in immortalized human chondrocytes led to significantly improved mitochondrial membrane potentials and reduced levels of intracellular reactive oxygen species (ROS), mitochondrial ROS and apoptosis.ConclusionsThis study rudimentarily demonstrates the correlation between CRGs and immune cell infiltration in RA. The biomarker DLAT may provide comprehensive insights into the pathogenesis and drug targets of RA.
Public finance management architecture in Tajikistan: International reform advice and domestic reform practice
Authors: Khujamkulov Ismoil 
Published: June 2023

AbstractDebates persist on the effectiveness of externally driven Public Finance Management (PFM) reforms in developing countries, with limited empirical research and field investigations in the Central Asian region. This study collected evidence through Solution and Leader Driven Change (SLDC) and Problem Driven Iterative Adaptation (PDIA) theoretical framework explanations, policy documents review, interview and survey results and Public Expenditure and Financial Accountability (PEFA) framework assessments to find that not all of the World Bank's advice on PFM improvement was adopted in the first phase of reforms in Tajikistan. Blending SLDC and PDIA arguments, the study investigates both positive deviants and reform failures.
An open competition involving thousands of competitors failed to construct useful abstract classifiers for new diagnostic test accuracy systematic reviews
Authors: Kataoka Yuki , Taito Shunsuke , Yamamoto Norio , So Ryuhei , Tsutsumi Yusuke , Anan Keisuke , Banno Masahiro , Tsujimoto Yasushi , Wada Yoshitaka , Sagami Shintaro , Tsujimoto Hiraku , Nihashi Takashi , Takeuchi Motoki , Terasawa Teruhiko , Iguchi Masahiro , Kumasawa Junji , Ichikawa Takumi , Furukawa Ryuki , Yamabe Jun , Furukawa Toshi A. 
Published: June 2023

AbstractThere are currently no abstract classifiers, which can be used for new diagnostic test accuracy (DTA) systematic reviews to select primary DTA study abstracts from database searches. Our goal was to develop machine‐learning‐based abstract classifiers for new DTA systematic reviews through an open competition. We prepared a dataset of abstracts obtained through database searches from 11 reviews in different clinical areas. As the reference standard, we used the abstract lists that required manual full‐text review. We randomly splitted the datasets into a train set, a public test set, and a private test set. Competition participants used the training set to develop classifiers and validated their classifiers using the public test set. The classifiers were refined based on the performance of the public test set. They could submit as many times as they wanted during the competition. Finally, we used the private test set to rank the submitted classifiers. To reduce false exclusions, we used the Fbeta measure with a beta set to seven for evaluating classifiers. After the competition, we conducted the external validation using a dataset from a cardiology DTA review. We received 13,774 submissions from 1429 teams or persons over 4 months. The top‐honored classifier achieved a Fbeta score of 0.4036 and a recall of 0.2352 in the external validation. In conclusion, we were unable to develop an abstract classifier with sufficient recall for immediate application to new DTA systematic reviews. Further studies are needed to update and validate classifiers with datasets from other clinical areas.
Quality of life of older gynecologic oncology patients at the initiation of chemotherapy
Authors: Kleven Anne Grethe , Miaskowski Christine , Torstveit Ann Helen , Ritchie Christine Seel , Engh Marie Ellström , Andersen Elin , Utne Inger 
Published: June 2023

AbstractAimTo evaluate older gynecologic oncology patients' quality of life (QOL) at the initiation of chemotherapy and compare their QOL scores with a female age‐matched general population (GP) sample.DesignCross‐sectional.MethodsOlder (n = 122) gynecologic oncology patients completed the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (QLQ‐C30) that evaluates global health and five functional scales (range from 0 to 100). Differences in QOL scores between our sample and the GP were evaluated using one‐sample t‐tests and effect sizes were calculated using Cohen's d.ResultsPatients' mean age was 70.7 years (±6.6). Mean scores for the function scales ranged from 58.5 (±31.1) for role function to 86.1 (±17.0) for cognitive function. Compared to the GP, our sample reported significantly lower scores for global health status, social, role and physical functioning, and a significantly higher score for cognitive functioning. No differences were found in emotional functioning scores.Patient or Public ContributionNo patient or public contribution.
A new high order hybrid WENO scheme for hyperbolic conservation laws
Authors: Li Liang , Wang Zhenming , Zhao Zhong , Zhu Jun 
Published: June 2023

AbstractThis article proposes an improved hybrid weighted essentially non‐oscillatory (WENO) scheme based on the third‐ and fifth‐order finite‐difference modified WENO (MWENO) schemes developed by Zhu et al. in (SIAM J. Sci. Comput. 39 (2017), A1089–A1113.) for solving hyperbolic conservation laws. The MWENO schemes give a guideline on whether to use the WENO scheme or the linear upwind scheme. Unfortunately, because there is no explicit formula for computing the roots of algebraic polynomials of order four or higher, it is difficult to generalize this criterion to higher order cases. Therefore, this article proposes a simple criterion for constructing a series of seventh‐, ninth‐, and higher‐order hybrid WENO schemes, and then designs a class of improved smooth indicator WENO (WENO‐MS) schemes. Compared with the classical WENO schemes, the main advantages of the WENO‐MS schemes are their robustness and efficiency. And these WENO‐MS schemes are more efficient, have better resolution, and can solve many extreme problems without any additional techniques. Furthermore, a simplification criterion is proposed to further improve the computational efficiency of the WENO‐MS schemes, and these simple WENO‐MS schemes are abbreviated as WENO‐SMS schemes in this article. Extensive numerical results demonstrate the good performance of the WENO‐MS schemes and the WENO‐SMS schemes.