bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyethylenimine-based iron oxide nanoparticles enhance cisplatin toxicity in ovarian cancer cells in the presence of a static magnetic field
Authors: Ashoori Faranak , Hajipour-Verdom Behnam , Satari Mohammad , Abdolmaleki Parviz 
Published: September 2023

BackgroundDrug resistance in cancer cells is a major concern in chemotherapy. Cisplatin (CIS) is one of the most effective chemotherapeutics for ovarian cancer. Here, we investigated an experimental approach to increase CIS cytotoxicity and overcome cell resistance using nanoparticle-based combination treatments.MethodsPolyethylenimine (PEI)-based magnetic iron oxide nanocomplexes were used for drug delivery in genetically matched CIS-resistant (A2780/CP) and -sensitive (A2780) ovarian cancer cells in the presence of a 20 mT static magnetic field. Magnetic nanoparticles (MNPs) were synthesized and bonded to PEI cationic polymers to form binary complexes (PM). The binding of CIS to the PM binary complexes resulted in the formation of ternary complexes PM/C (PEI–MNP/CIS) and PMC (PEI–MNP–CIS).ResultsCIS cytotoxicity increased at different concentrations of CIS and PEI in all binary and ternary delivery systems over time. Additionally, CIS induced cell cycle arrest in the S and G2/M phases and reactive oxygen species production in both cell lines. Ternary complexes were more effective than binary complexes at promoting apoptosis in the treated cells.ConclusionPEI-based magnetic nanocomplexes can be considered novel carriers for increasing CIS cytotoxicity and likely overcoming drug resistance of ovarian cancer cells.
Can mothers’ representations of their infants be improved in primary care? A randomized controlled trial of a parenting intervention using video feedback in a predominantly low- to moderate-risk sample
Authors: Sandnes Kjersti , Berg-Nielsen Turid Suzanne , Lydersen Stian , Kårstad Silja Berg 
Published: September 2023

IntroductionMothers’ representations of their infants are important intervention targets because they predict the observed quality of infant–mother interactions. The current study investigated the influence of a video-feedback infant-parent intervention on mothers’ representations of their infants beyond the effect of standard treatment.MethodsData from a naturalistic, randomized controlled trial of 152 predominantly low- to moderate-risk mothers (mean age = 29.7 years) with infants (mean age = 7.3 months) were used. At Well Baby Centers, all families followed the universal program, which was treatment as usual (TAU), whereas half of the families also received the intervention. The Working Model of the Child Interview categories and scales as well as three latent factors generated from a factor analysis were used to assess maternal representations at baseline and follow-up (9–13 months after baseline). A linear mixed model analysis was used to analyze the data.ResultsThere were no differences in representation changes from baseline to follow-up between the control group (TAU) and intervention group. When both groups were combined, there were minor improvements in the mothers’ representations at the follow-up.DiscussionAspects of the intervention, the quality of TAU, and the homogeneity scores of the predominantly low-risk sample may explain the intervention’s lack of effect on mothers’ representations beyond TAU. The supportive services at Norwegian Well Baby Centers as well as the infants’ increasing age putatively contributed to the improved features of the mothers’ representations in the total sample. That standard community care may affect maternal representations has not been shown before. Future research should identify the core components in interventions targeting maternal representations and examine whether those components can be incorporated in primary care. Including measures of mothers’ reflective functioning could broaden our knowledge of representations and their changeability.Clinical trial registrationThis study is registered in the International Standard Randomized Controlled Trial Number registry under the reference number ISRCTN 99793905.
Barriers and facilitators of the implementation of the application of pelvic floor muscle training in patients with prostate cancer: a scoping review
Authors: Wang Lijuan , Li Yaqin , Qi Ziyi , Wang Wei 
Published: September 2023

BackgroundPatients with prostate cancer (PCa) benefit significantly from pelvic floor exercises, but recent results indicate that these exercises have not been fully promoted in clinical settings. This scoping review aimed to identify the facilitators of and barriers to pelvic floor muscle training (PFMT) in PCa survivors.MethodsA scoping review was conducted in November 2022. Relevant studies were identified from CINAHL, Embase, PubMed, PsycINFO, and Web of Science databases from their inception to 20 November 2022. Data were analyzed and extracted by two formally trained researchers.ResultsA total of 53 studies were included, most of which were randomized controlled trials. The Tailored Implementation for Chronic Diseases (TICD) model framework was used to identify the contents of seven barriers and promotion areas, as well as a series of sub-domains. The most common barriers to implementing pelvic floor muscle training (PFMT) included the following: the lack of a common scheme in guidelines and the measurement of common standardized outcomes, inadequate self-monitoring or feedback from healthcare professionals to improve PFMT compliance, poor patient compliance, and a lack of implementation equipment and financial support. Good treatment effects and easy operation were the facilitators of PFMT.ConclusionThe implementation of PFMT faces several challenges and opportunities that should be understood thoroughly before implementation. In terms of guidelines and clinical practice, more work is needed, and the possibility of PFMT implementation in various hospitals and community health centers or clinics should be considered.
A perspective on potential psychological risks and solutions of using virtual reality in palliative care
Authors: Woo Olive K. L. , Lee Antoinette M. 
Published: September 2023

Initial evidence suggests that virtual reality (VR) can effectively reduce palliative symptoms. While such findings shed a positive light on the ability of VR exposure to improve patients’ physical and emotional symptoms, VR could have downsides with adverse effects. As most of the reported adverse effects are related to physical risks or technical challenges, there is a scarcity of reports on possible psychological risks posed by VR exposure in palliative care settings, an area with considerable concerns. This is an area that is likely to have a significant impact on the future of clinical practice and research on the use of VR in palliative care. Based on the clinical experience of a registered clinical psychologist who has delivered VR in a palliative care unit for 3 years, we put forward a perspective on the potential psychological complications of using VR in palliative care. Our clinical experiences show that exposure to a desirable virtual environment that is beneficial to patients might not always align with realistic expectations, and that should the use of VR be considered, special precautions are needed to minimize possible psychological harms. This perspective article further proposes three approaches aiming to minimize possible psychological hazards: incorporation of psychological assessment prior to VR administration, psychological interventions right after VR, and professional training of the VR facilitators. We hope that our personally witnessed concerns and perspectives can alert future VR facilitators to the potential psychological hazards of using VR for patients receiving palliative care and inspire future research to minimize psychological harms.
Oomycete Soil Diversity Associated with Betula and Alnus in Forests and Urban Settings in the Nordic–Baltic Region
Authors: Riit Taavi , Cleary Michelle , Adamson Kalev , Blomquist Mimmi , Burokienė Daiva , Marčiulynienė Diana , Oliva Jonàs , Poimala Anna , Redondo Miguel Angel , Strømeng Gunn Mari , Talgø Venche , Tedersoo Leho , Thomsen Iben Margrete , Uimari Anne , Witzell Johanna , Drenkhan Rein 
Published: September 2023

This study aimed to determine the differences and drivers of oomycete diversity and community composition in alder- and birch-dominated park and natural forest soils of the Fennoscandian and Baltic countries of Estonia, Finland, Lithuania, Norway, and Sweden. For this, we sequenced libraries of PCR products generated from the DNA of 111 soil samples collected across a climate gradient using oomycete-specific primers on a PacBio high-throughput sequencing platform. We found that oomycete communities are most affected by temperature seasonality, annual mean temperature, and mean temperature of the warmest quarter. Differences in composition were partly explained by the higher diversity of Saprolegniales in Sweden and Norway, as both total oomycete and Saprolegniales richness decreased significantly at higher longitudes, potentially indicating the preference of this group of oomycetes for a more temperate maritime climate. None of the evaluated climatic variables significantly affected the richness of Pythiales or Peronosporales. Interestingly, the relative abundance and richness of Pythiales was higher at urban sites compared to forest sites, whereas the opposite was true for Saprolegniales. Additionally, this is the first report of Phytophthora gallica and P. plurivora in Estonia. Our results indicate that the composition of oomycetes in soils is strongly influenced by climatic factors, and, therefore, changes in climate conditions associated with global warming may have the potential to significantly alter the distribution range of these microbes, which comprise many important pathogens of plants.
Effects of Aphrodite (an Herbal Compound) on SSRI-Induced Sexual Dysfunctions and Depression in Females with Major Depressive Disorder: Findings from a Randomized Clinical Trial
Authors: Shahmoradi Nasrin , Davarinejad Omran , Brühl Annette Beatrix , Brand Serge 
Published: September 2023

Background and Objectives: Almost by default, people with major depression disorder (MDD) also report sexual health issues. This holds even more true when sexual dysfunctions are SSRI-induced. Herbal compounds may have the power to counterbalance such sexual dysfunctions, though research is still scarce. Therefore, we assessed females with diagnosed MDD treated with a standard SSRI (sertraline) and reporting SSRI-induced sexual dysfunctions, and we asked whether compared to placebo, Aphrodite (a blend of ginger, saffron, cinnamon, thistle, and Tribulus terrestris) may favorably impact on sexual dysfunctions, and on symptoms of depression, anxiety, and sleep disturbances. Materials and Methods: A total of 41 females (mean age: 35.05 years) with diagnosed MDD, treated with sertraline (a standard SSRI) at therapeutic dosages, and reporting SSRI-induced sexual dysfunction, were randomly assigned either to Aphrodite or to the placebo condition. At baseline and four and eight weeks later (study end), participants completed a series of self-rating questionnaires covering symptoms of sexual dysfunction, depression, anxiety, and sleep complaints. Results: Symptoms of sexual dysfunction, depression, and anxiety decreased over time, but more so in the Aphrodite condition, compared to the placebo condition (significant p-values and large effect sizes). Over time, sleep disturbances decreased irrespective of the study condition. Conclusions: The pattern of results suggests that compared to placebo, Aphrodite appeared to improve symptoms of sexual dysfunction, depression, and anxiety among females with diagnosed MDD and SSRI-induced sexual dysfunction. Further and similar studies should investigate the underlying psychophysiological mechanisms.
DO GREEN BRAND POSITIONING, GREEN BRAND KNOWLEDGE, ATTITUDE TOWARDS GREEN BRAND, AND ENVIRONMENTAL CONCERN ARE INFLUENCE FACTORS FOR THE GREEN PURCHASE INTENTION OF BLACK SOLDIER FLY LARVAE?
Authors: Bagaskara Dewana Traya , Salim Lina 
Published: September 2023

The increasing number of human populations certainly has a bad influence on the environment. Food sources for humans also need a source of protein. For this reason, alternative protein sources are needed that can save threatened fish populations. This study is very simple, but the issue is very important for the environment. The purpose of this study is to determine the effect of green brand positioning, green brand knowledge, attitude towards green brand, and environmental concern on green purchase intention of black soldier fly larvae. The data used in this study is primary data obtained through distributing questionnaires to followers of Instagram (IG) Magalarva Tbk. The sample criteria in this study are 18-30 years old who know the Magalarva Tbk have never bought Magalarva products, and are domiciled in Greater Jakarta. The sampling method used is nonprobability sampling (purposive). All hypotheses are accepted. The results show that green brand positioning, green brand knowledge, attitude towards green brands, and environmental concerns have a significant effect on green purchase intention for the product of Magalarva’s brand.
La fertilité de l’inexact
Authors: Kappès-Le Moing Morgane 
Published: September 2023

Hugo von Hofmannsthal, dans sa Dame Kobold, transforme la Dama duende de Calderón sans s’éloigner du texte original puisqu’il encadre ses transformations de citations. Il adapte ainsi l’œuvre au public de son temps et permet sa transmission. Il développe aussi des aspects procédant des rares inexactitudes de la traduction de Gries, qui est visiblement sa seule voie d’accès au texte caldéronien : la fidélité le conduit ainsi paradoxalement à l’originalité.
La citation volponienne (1924-1994)
Authors: Candiloro Mauro 
Published: September 2023

Tout en s’inscrivant dans la pratique affective de la citation propre aux poètes italiens du second après-guerre, l’acte citationnel de Paolo Volponi (1924-1994) sait aussi sortir de l’hommage aux pères pour acquérir une valeur plus politique. Citations, allusions, stylisation et parodie deviennent alors autant d’armes que Volponi emploie pour sommer le (dés)ordre capitaliste de comparaître devant le tribunal de sa page.
La relation épistolaire de Juste Lipse et Francisco de Quevedo
Authors: Audoubert Rafaèle 
Published: September 2023

Rafaèle Audoubert étudie un court échange épistolaire (4 lettres), en latin, entre Juste Lipse et Francisco de Quevedo, hommes qu’a priori tout sépare : l’espace, l’âge, la nationalité et la notoriété. Juste Lipse est alors un éminent savant flamand de près de soixante ans, Queævedo un jeune poète espagnol d’une vingtaine d’années. Seuls les rapprochent leur goût pour les grands auteurs hispaniques de l’Antiquité (Martial, Lucain, Quintilien, Sénèque), et la religion. Quevedo est catholique. Après avoir adhéré au luthéranisme, Juste Lipse l’a abjuré lors d’une conversion publique. On le dit très dévot de la Vierge. La première lettre, de Quevedo à Juste Lipse, est obséquieuse. Il y prend prétexte d’un détail de traduction de Macrobe pour entrer en contact avec un Maître respecté, dont il quémande humblement les lumières. Juste Lipse ne lui a pas répondu sur ce point (sans doute n’était-il pas d’accord), mais une correspondance s’est engagée entre Maître et disciple. Elle prend fin avec la mort du Maître, mais semble s’être détériorée avant, en raison de la Guerre des Flandres.
« Un voyage au fond de ma mémoire »
Authors: Dario Maria 
Published: September 2023

Avec Maria Dario, on arrive aux temps modernes. Son article est consacré à quinze lettres (1916-1917) résultant d’un « contrat épistolaire » passé entre l’écrivain André Salmon et Jacques Doucet, son riche mécène. Alors que la guerre fait rage, ce dernier veut constituer une « bibliothèque idéale de la modernité » en passant commande à des artistes de lettres faisant le point sur l’état de l’Art, à raison d’une par mois. Tous n’acceptèrent pas cette posture de « Schéhérazade ». Blaise Cendras préféra livrer un roman. Quant aux « contrats » conclus, ils finirent presque tous par une rupture, comme dans le cas d’André Salmon, auquel la tension entre le monde de l’argent et celui de l’art finit par apparaître insupportable. Si ses lettres témoignent de désaccords croissants, on y trouve aussi une liberté de jugement qu’on chercherait en vain dans le reste de son œuvre, notamment vis-vis de Paul Fort, qu’il qualifie cruellement de « champêtre et libertin, Orphée au bal musette, Rodolphe à Montfermeil ».
PENGARUH PENGETAHUAN (KNOWLEDGE) DAN PERTIMBANGAN (JUDGEMENT) TERHADAP PENGAMBILAN KEPUTUSAN (DECISION MAKING) MENGGUNAKAN BRT BANJARBAKULA
Authors: Silvia Arisanthi Pratiwi  , Arifia Nurriqli  
Published: September 2023

Abstrak: Penelitian ini memiliki tujuan ingin mengetahui dan menganalisis pengaruh pengetahuan dan pertimbangan terhadap pengambilan keputusan menggunakan BRT Banjarbakula baik secara simultan, parsial, dan dominan. Jenis penelitian yang digunakan adalah penelitian korelasional dengan jumlah sampel sebanyak 384 orang (pengguna). Teknik analisis data yang digunakan dalam penelitian ini meliputi uji instrumen (validitas dan reliabilitas), uji asumsi klasik, dan analisis regresi linier berganda. Hasil penelitian dapat disimpulkan bahwa terdapat pengaruh baik secara simultan dan parsial dari variabel pengetahuan dan pertimbangan terhadap pengambilan keputusan.
Kata kunci: Pengetahuan, Pertimbangan, Pengambilan Keputusan
cppPosit: a C++ template-based library implementing Posit arithmetic ready for machine learning applications
Authors: Ruffaldi Emanuele , Rossi Federico , Cococcioni Marco , Saponara Sergio 
Published: September 2023

<p>This paper presents cppPosit, a C++ open source library to represent real numbers according to a novel format called Posit, recently introduced in literature. The library offers an unique implementation of numeric traits and templatization making it able to be hot-swapped in a machine learning library with very few modifications. The capabilities of the library are shown benchmarking the k-Nearest Neighbours (k-NN) algorithm, a widely used routine in machine learning. The k-NN algorithm can be implemented using different data structures. One of the most interesting and widely used is the kd-tree. In this work we first improve the kd-tree data structure, in order to make it more accurate and robust when working with small reals, i.e., floating point real numbers represented on a low number of bits (16, 14, 12, 10 or even 8). Then we compare the accuracy of the kd-tree based k-NN algorithm for different choices of Floats and Posits, showing how the Posit format assures a higher accuracy, when using the same number of total bits. Finally we also compare the accuracy of several Deep Neural Networks (DNNs) when using posits and standard 32-bit floating point numbers, showing the little-to-none drop in accuracy when using 16-bit or even 8-bit posit precisions. </p>
Teknologi Biogas Purifier dengan metode Water Washing-adsorption) sebagai Optimasi Gas Metan untuk Efisisensi Produksi Usaha Rumah Tangga di Kabupaten Sorong
Authors: Rahim Nurfitri , Efendi Ivan Agustian , Syaiku Syaiku , Iriani Rika Tundan , Meishah Nurul , Sholikatin Annisa , Suhria Suhria , Firman Sri Wahyuni , Rossarie Dheni , Risfany Risfany , Athirah Aldila Mawanti 
Published: September 2023

Kabupaten Sorong merupakan kabupaten yang memiliki industri makan dan minuman terbesar di provinsi Papua Barat dengan total 26 usaha industri makanan dan minuman (BPS, 2019). salah satu desa yang terkenal memiliki usaha industri kuliner yang berkembang yaitu berada di desa Klasmelek. Biogas adalah gas yang dihasilkan oleh bakteri apabila bahan organic mengalami proses fermentasi dalam reactor (biodigester) dalam kondisi anaerob (tanpa udara). Kandungan CO2 pada biogas masih cukup besar. Tahap pembuatan biogas purifier terdiri dari tiga tahap yaitu Tahap input, Tahap Black Box, Output setelah pembuatan biogas purifier selanutnya yaitu Penerapan alat kepada mitra dilakukan dengan metode penyuluhan. Persiapan pertama yang dilakukan dalam perancangan desain biogas purifier yaitu persiapan alat dan bahan contohnya pembelian stik las, amplas dan perakitan. Penyuluhan ini dilakukan kepada masyarakat yang memiliki usaha dibidang kuliner di Kampung Klasmelek. Penyuluhan dilakukan dengan metode presentasi. Pada saat presentasi dijelaskan tentang deskripsi alat, cara pemakaian alat melalui buku pedoman serta uji coba secara langsung pada sampel. Teknologi biogas purifier dengan metode water washing – adsorption dapat memaksimalkan kualitas gas yang dihasilkan sehingga dapat menekan biaya proses produksi olahan makanan mitra.
Gerakan Literasi Baca Tulis Bagi Siswa SD Negeri 17 Kabupaten Sorong
Authors: Hafid Abdul , Hatsama Abdurahman , Mustia Ari , Febrianto Febrianto , Jaya Isni Irna , Halisah Halisah , Ardiansyah M. Fathur , Yuyanti Tri 
Published: September 2023

Kegiatan pengabdian kepada masyarakat ini berfokus pengajaran baca tulis bagi siswa kelas IV SD Negeri 17 Kabupaten Sorong. Metode pelaksanaan terdiri dari persiapan, pelaksanaan, evaluasi, dan penyusunan laporan. Pelaksanaan program pengabdian kepada masyarakat dengan judul Gerakan Literasi Baca Tulis Bagi Siswa SD Negeri 17 Kabupaten Sorong dapat meningkatakan kemampuan membaca dan menulis siswa, khususnya siswa kelas IV.
VIOLÊNCIA DOMÉSTICA, LEI MARIA DA PENHA E OS FATORES QUE INFLUENCIAM A DENÚNCIA
Authors: Josiane Pinheiro Prestes de Souza  , Fátima Regina Ney Matos  , Ivanez Pinheiro Prestes  
Published: September 2023

Introdução: As situações de violência no âmbito conjugal resultam numa diversidade de consequências e danos físicos, psicológicos, relacionais e nos casos mais graves, poderão conduzir à incapacitação, temporária ou permanente, da vítima ou, mesmo, à sua morte. A Lei Maria da Penha, dispõe a respeito da criação de mecanismos para coibir a violência doméstica e familiar contra mulher; trata também da Convenção sobre a Eliminação de Todas as Formas de Discriminação contra as Mulheres e da Convenção Interamericana para Prevenir, Punir e Erradicar a Violência contra a Mulher. Dispõe ainda a respeito da criação dos Juizados de Violência Doméstica e Familiar contra Mulher e promove alteração no Código Penal e na lei de Execução Penal a respeito da punição da violência contra a mulher. Objetivo: Identificar e compreender os fatores que influenciam a tomada de decisão da vítima em denunciar atos de violência doméstica. Especificamente pretende-se verificar o conhecimento dos recursos disponíveis à vítima de violência doméstica, bem como analisar se tais recursos influenciam na decisão da vítima denunciar o agressor. Método: Foi feita uma pesquisa qualitativa básica, com a participação de 12 mulheres que se identificaram como vítimas de violência doméstica. Foi utilizada como técnica de colheita a entrevista semiestruturada e para o tratamento dos dados, foi feita análise categorial. Resultados: Das entrevistadas, quatro mulheres não denunciaram o agressor, uma destas saiu de casa e preferiu não denunciar. As que denunciaram, o fizeram por diferentes motivos, como traição, agressão na presença de filhos, medo de perder os filhos, entre outros. Conclusões. Os fatores apontados estão relacionados com a dependência financeira e emocional e por descrédito na justiça.