bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing a multi-objective mathematical model of a perishable supply chain (PSC) in a state of uncertainty
Authors: Fallah Fatemeh , Azimi Parham , Sharifi Mani 
Published: December 2022

Purpose
The pharmaceutical industry is one of the most essential areas of health in any country. It is defined as a system of processes, operations and organizations involved in discovering, developing and producing drugs. The supply chain in the pharmaceutical field is one of the most important strategic issues in the pharmaceutical and health-care industries. The purpose of this study is to reduce the total cost of the supply chain network and reduce the amount of distribution scheduling.

Design/methodology/approach
In this study, the authors designed a drug supply chain network with uncertainty-related corruption. The optimal number and location of potential facilities, the optimal allocation of flow between facilities, the optimal routing of vehicles and the optimal amount of inventory in production and distribution center warehouses were determined to achieve these two objective functions.

Findings
In evaluating the small sample size problem, it was found that the comprehensive benchmarking method was more efficient than the other methods in obtaining the mean index of the first objective function. The utility function method has also proved its efficiency in obtaining the mean of the second objective function indices, the spacing index and the computational time. Because of the inefficiency of GAMS software in resolving size issues, the modified NSGA II and MOPSO algorithms with modified priority-based encryption have been used. First, using the Taguchi method, the initial parameters of the metaheuristic algorithms are adjusted, and then, 15 sample problems are designed in larger sizes. To avoid generating random data, five problems were equally designed, and the averages of objective functions and metrics of met heuristic algorithms (number of efficient solutions, maximum expansion index, spacing index and computational time) were analyzed as the basis of evaluation and comparison. Therefore, using all the indicators and results of the NSGA II algorithm is recommended.

Originality/value
In this research, a biobjective modeling approach is proposed to minimize the total costs of the supply chain network (construction costs, storage costs and product transportation costs between centers) and advertising costs and to minimize distribution and transportation scheduling across each level of the supply chain network.
Suffering, recovery and participant experience in a video game development accelerator
Authors: Gidley Devon , Palmer Mark , Gharib Amani 
Published: December 2022

PurposeThe authors aimed to explore how involvement in a creative development accelerator impacted participants. In particular, the authors considered the role of suffering in the acceleration process.Design/methodology/approachThe authors conducted an ethnography of a rapid prototyping program in video game development. Data collection included participant observation (162 h before, 186 during and 463 h after the main prototyping), interviews (23 formal and 35 informal) and artifact analysis (presentations, documents, games).FindingsAcceleration led to individual suffering via burnout, lack of sleep, overwork and illness. In turn, participants required varying periods of recovery after participation and diverged in their longer-term reaction to the experience. The authors make two contributions. First, the authors deepen empirical understanding of the embodied impact of participation in an organizational accelerator. Second, the authors develop a theoretical process model of suffering in an accelerator program based on time and initiation.Research limitations/implicationsThis paper focused on a single iteration of a program based out of an incubator in the United Kingdom (UK) Suffering was discovered as part of a larger study of the program.Practical implicationsBusiness and technology accelerators are becoming a popular way to organize work. This research suggests that accelerator structures might lead to unintended and negative participant experiences.Originality/valueThis research challenges the assumption that accelerators always benefit, or at least not hurt, participants. The authors add to the limited attention paid to suffering in organizations. The authors conclude the impact of an accelerator is more complex than usually portrayed.
“Things have to change!” How and when change-oriented leaders and idea championing employees can address organizational underperformance through performance pressures
Authors: Azeem Muhammad Umer , De Clercq Dirk , Ul Haq Inam 
Published: December 2022

PurposeThis study investigates how and when employees' exposure to organizational leaders who propose major changes might direct those employees toward efforts to mobilize support for innovative ideas. It specifically theorizes a mediating role of performance pressure beliefs and a moderating role of perceived organizational underperformance in this process.Design/methodology/approachThree-wave, multi-rater survey data were collected among employees and their supervisors across various industries.FindingsA critical explanatory mechanism that links change-oriented leadership with enhanced championing efforts is that employees experience performance-related hardships. The extent to which employees perceive that their organization is unable to meet its own performance targets triggers this process.Practical implicationsFor organizational decision makers, the findings identify results-driven pressures as key mechanisms by which employees' exposures to change-oriented leadership can be leveraged to promote novel ideas. This translation is more likely among employees who are convinced that there is significant room for organizational improvement.Originality/valueThis study unravels the previously unexplored link between change-oriented leadership and idea championing, pinpointing the influences of two performance-related aspects: beliefs about strenuous organization-induced performance expectations and perceptions of an underperforming employer.
T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen
Authors: Takahashi Hayato , Iriki Hisato , Asahina Yasuhiko 
Published: December 2022

AbstractPemphigus is a life‐threatening autoimmune bullous disease mediated by anti‐desmoglein IgG autoantibodies. Pemphigus is mainly classified into three subtypes: pemphigus vulgaris, pemphigus foliaceus, and paraneoplastic pemphigus. The pathogenicity of autoantibodies has been extensively studied. Anti‐human CD20 antibody therapy targeting B cells emerged as a more effective treatment option compared to conventional therapy for patients with an intractable disease. On the other hand, autoreactive T cells are considered to be involved in the pathogenesis based on the test results of human leukocyte antigen association, autoreactive T cell detection, and cytokine profile analysis. Research on the role of T cells in pemphigus has continued to progress, including that on T follicular helper cells, which initiate molecular mechanisms involved in antibody production in B cells. Autoreactive T cell research in mice has highlighted the crucial roles of cellular autoimmunity and improved the understanding of its pathogenesis, especially in paraneoplastic pemphigus. The mouse research has helped elucidate novel regulatory mechanisms of autoreactive T cells, such as thymic tolerance to desmoglein 3 and the essential roles of regulatory T cells, Langerhans cells, and other molecules in peripheral tissues. This review focuses on the immunological aspects of autoreactive T cells in pemphigus by providing detailed information on various related topics.
Prevalence of cutaneous manifestations in COVID‐19: A meta‐analysis
Authors: Li Jingmin , Wen Weijing , Mu Zhenzhen , Du Xuefei , Han Xiuping 
Published: December 2022

AbstractThe global epidemic of coronavirus disease 2019 (COVID‐19) endangers more and more people. Many studies on cutaneous manifestations related to COVID‐19 have emerged, but their prevalence has varied widely. The objective of this study was to conduct a meta‐analysis estimating the prevalence of skin manifestations in COVID‐19. Four databases PubMed, Web of Science, CBM, and CNKI were searched, and the results were screened by two reviewers. A random‐effects model was used to evaluate the overall prevalence. Heterogeneity was assessed by I2. Further subgroup analyses were conducted by region, sample size, sex, age, and severity of COVID‐19. A funnel plot and Egger's test were performed to assess publication bias. The pooled prevalence of cutaneous manifestation of 61 089 patients in 33 studies was 5.6% (95% confidence intervals [CI] = 0.040–0.076, I2 = 98.3%). Severity of COVID‐19 was probably the source of heterogeneity. Studies with sample size <200 report higher prevalence estimates (10.2%). The prevalence of detailed types was as follows: maculopapular rash 2%, livedoid lesions 1.4%, petechial lesions 1.1%, urticaria 0.8%, pernio‐like lesions 0.5%, vesicular lesions 0.3%. Petechial lesions and livedoid lesions contain a higher proportion of severe patients than other skin manifestations. The prevalence rates of pernio‐like lesions, urticaria and petechial lesions vary greatly in different regions.
Effect of UVC‐LED and ultrasound alone and combined on heat‐resistant Escherichia coli isolated from pasteurised milk
Authors: Machado Maxsueli Aparecida Moura , Castro Vinicius Silva , Monteiro Maria Lúcia Guerra , Bernardo Yago Alves de Aguiar , Figueiredo Eduardo Eustáquio de Souza , Conte‐Junior Carlos Adam 
Published: December 2022

We aimed at characterising the nonthermal technologies resistance profile of two Escherichia coli strains isolated from pasteurised milk and described as moderate‐to‐high heat resistance (MHR) (60°C/6 min) harbouring or not a transmissible locus of stress tolerance (tLST). The characterisation was carried out applying optimised conditions of ultraviolet‐C light‐emitting diodes (UVC‐LED) (4950 mJ/cm2), ultrasound (US) (299 W) and their combination (UVC‐LED + US). Both strains were more sensitive to UVC‐LED (4.5–1.5 log cfu/mL) than to US (<1 log cfu/mL) or UVC‐LED + US (4.5–1.5 log cfu/mL), which did not exhibit synergism. Thus, UVC‐LED is a promising technology to eliminate E. coli harbouring tLST.
A comprehensive review of furan in foods: From dietary exposures and in vivo metabolism to mitigation measures
Authors: Zhang Yiju , Zhang Yu 
Published: December 2022

AbstractFuran is a thermal food processing contaminant that is ubiquitous in various food products such as coffee, canned and jarred foods, and cereals. A comprehensive summary of research progress on furan is presented in this review, including discussion of (i) formation pathways, (ii) occurrence and dietary exposures, (iii) analytical techniques, (iv) toxicities, (v) metabolism and metabolites, (vi) risk assessment, (vii) potential biomarkers, and (viii) mitigation measures. Dietary exposure to furan varies among different countries and age groups. Furan acts through various toxicological pathways mediated by its primary metabolite, cis‐2‐butene‐1,4‐dial (BDA). BDA can readily react with glutathione, amino acids, biogenic amines, or nucleotides to form corresponding metabolites, some of which have been proposed as potential biomarkers of exposure to furan. Present risk assessment of furan mainly employed the margin of exposure approach. Given the widespread occurrence of furan in foods and its harmful health effects, mitigating furan levels in foods or exploring potential dietary supplements to protect against furan toxicity is necessary for the benefit of food safety and public health.
Study of the persistence and dynamics of recombinant mCherry‐producing Yarrowia lipolytica strains in the mouse intestine using fluorescence imaging
Authors: Madzak Catherine , Poiret Sabine , Salomé Desnoulez Sophie , Foligné Benoit , Lafont Frank , Daniel Catherine 
Published: December 2022

AbstractYarrowia lipolytica is a dimorphic oleaginous non‐conventional yeast widely used as a powerful host for expressing heterologous proteins, as well as a promising source of engineered cell factories for various applications. This microorganism has a documented use in Feed and Food and a GRAS (generally recognized as safe) status. Moreover, in vivo studies demonstrated a beneficial effect of this yeast on animal health. However, despite the focus on Y. lipolytica for the industrial manufacturing of heterologous proteins and for probiotic effects, its potential for oral delivery of recombinant therapeutic proteins has seldom been evaluated in mammals. As the first steps towards this aim, we engineered two Y. lipolytica strains, a dairy strain and a laboratory strain, to produce the model fluorescent protein mCherry. We demonstrated that both Y. lipolytica strains transiently persisted for at least 1 week after four daily oral administrations and they maintained the active expression of mCherry in the mouse intestine. We used confocal microscopy to image individual Y. lipolytica cells of freshly collected intestinal tissues. They were found essentially in the lumen and they were rarely in contact with epithelial cells while transiting through the ileum, caecum and colon of mice. Taken as a whole, our results have shown that fluorescent Y. lipolytica strains constitute novel tools to study the persistence and dynamics of orally administered yeasts which could be used in the future as oral delivery vectors for the secretion of active therapeutic proteins in the gut.
Current trends in waste valorization
Authors: Rene Eldon R. , Sarangi Prakash K. , Sànchez i Nogué Violeta , Schnürer Anna , Salvachúa Davinia 
Published: December 2022

AbstractThis paper presents the scientific breakthroughs made in bioprocess engineering and microbial biotechnology for the conversion of wastes into products with added value and/or biofuels. The significant results obtained in the emerging fields of hybrid electrosynthesis, the role of enzymes in the degradation of plastics, polyhydroxyalkanoate and 5‐aminolevulinic acid production, fermentation technology and the application of molecular engineering tools to bioprocess technology are highlighted.
Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal
Authors: Kuehnemann Chisaka , Hughes Jun‐Wei B. , Desprez Pierre‐Yves , Melov Simon , Wiley Christopher D. , Campisi Judith 
Published: December 2022

AbstractAntiretroviral drugs have dramatically improved the prognosis of HIV‐infected patients, with strikingly reduced morbidity and mortality. However, long‐term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nucleoside reverse transcriptase inhibitors (NRTIs), with one of three additional antiretroviral drug classes, including protease inhibitors (PIs). One commonality between mitochondrial dysfunction (induced by NRTIs) and defects in lamin A (induced by PIs) is they can cause or accelerate cellular senescence, a state of essentially irreversible growth arrest, and the secretion of many bioactive molecules collectively known as the senescence‐associated secretory phenotype (SASP). We hypothesized that senescent cells increase following treatment with certain HIV therapies. We compared the effects of two distinct HIV PIs: ritonavir‐boosted atazanavir (ATV/r) and ritonavir‐boosted darunavir (DRN/r), used in combination treatments for HIV infection. Upon ATV/r, but not DRN/r, treatment, cells arrested growth, displayed multiple features of senescence, and expressed significantly upregulated levels of many SASP factors. Furthermore, mice receiving sustained ATV/r treatment showed an increase in senescent cells and age‐related decline in physiological function. However, removing treatment reversed the features of senescence observed in vivo and cell culture. Given how these features disappeared with drug removal, certain features of senescence may not be prognostic as defined by an irreversible growth arrest. Importantly, for patients that are treated or have been treated with ATV/r, our data suggest that switching to another PI that does not promote premature aging conditions (DRN/r) may improve the associated age‐related complications.
Role of autophagy in aging: The good, the bad, and the ugly
Authors: Tabibzadeh Siamak 
Published: December 2022

AbstractAutophagy (self‐eating) is a conserved catabolic homeostatic process required for cellular metabolic demands by removal of the damaged molecules and organelles and for alleviation of stress initiated by pathology and infection. By such actions, autophagy is essential for the prevention of aging, disease, and cancer. Genetic defects of autophagy genes lead to a host of developmental, metabolic, and pathological aberrations. Similarly, the age‐induced decline in autophagy leads to the loss of cellular homeostatic control. Paradoxically, such a valuable mechanism is hijacked by diseases, during tumor progression and by senescence, presumably due to high levels of metabolic demand. Here, we review both the role of autophagy in preventing cellular decline in aging by fulfillment of cellular bioenergetic demands and its contribution to the maintenance of the senescent state and SASP by acting on energy and nutritional sensors and diverse signaling pathways.
Estimates of genomic inbreeding and identification of candidate regions in Beijing‐You chicken populations
Authors: Wang Qiao , Zhang Jin , Wang Hailong , Wang Zixuan , Li Qinghe , Zhao Guiping , Zheng Maiqing , Wen Jie 
Published: December 2022

AbstractRuns of homozygosity (ROHs) has become an effective method for analysing inbreeding in livestock populations. Moreover, ROHs is well‐suited to detect signatures of selection via ROH islands. This study aimed to investigate the occurrence and distribution of ROHs, compare the genomic inbreeding coefficients and identify the genomic regions with high ROH frequencies in different Beijing‐You chicken (BY) populations, including a random conservation population (BY_R), a pedigree conservation population (BY_P), and a commercial population obtained from the market (BY_C). Among them, BY_R in 2010 and 2019 were BY_R1 and BY_R2 respectively. A total of 27 916 ROHs were identified. The average number of ROHs per individual across the three BY populations ranged from 213 (BY_P) to 161 (BY_C), and the average length of ROHs ranged from 0.432 Mb (BY_R2) to 0.451 Mb (BY_P). The highest inbreeding coefficient calculated based on ROHs (FROH) was 0.1 in BY_P, whereas the lowest FROH was 0.0743 in BY_C. In addition, the inbreeding coefficient of BY_R2 (FROH = 0.0798) was higher than that of BY_R1 (FROH = 0.0579). Furthermore, the highest proportion of long ROH fragments (>4 Mb) was observed in BY_P and BY_C. This study showed the top 10 ROH islands of each population, and these ROH islands harboured 53 genes, some of which were related to limb development, body size and immune response. These findings contribute to the understanding of genetic diversity and population demography, and might help improve breeding and conservation strategies for BY populations.
Facilitating advance care planning in the thriving retirement village setting
Authors: Polacsek Meg , Porter Tabitha 
Published: December 2022

AbstractObjectivesTo investigate the factors that influence the adoption of advance care planning (ACP) in the retirement village setting.MethodsPurposive sampling was used to recruit residents and staff from a retirement village in a regional town in Victoria, Australia. Data collected in semistructured interviews were analysed through a process of reflexive thematic analysis and coded in NVivo.ResultsTwenty participants, comprising 14 residents and six staff, participated in the study. Four main themes arose, relating to awareness of the ACP process, the logistics of ACP, the role of service providers in facilitating ACP, and trust in the process. Most residents were unaware of the ACP process, but thought the transition into a retirement village was a good time to prepare instructions. Being given information on ACP was appropriate, but participants agreed that staff should not be involved in the actual ACP process. Finally, concerns were raised about the extent to which participants could trust that their wishes would be followed.ConclusionsViewed along a continuum of care, the retirement village setting is an appropriate point at which to inform and support the ACP process, particularly for providers offering incremental support in response to changing client needs. These findings add to the relatively limited literature on ACP in this setting and could inform the development of strategies and resources to support residents in the ACP process. In so doing, they support best practice for facilitating ACP across care settings.
The role of surveillance imaging for resected high‐risk melanoma
Authors: Yan Mabel K. , Adler Nikki R. , Wolfe Rory , Pan Yan , Chamberlain Alexander , Kelly John , Yap Kenneth , Voskoboynik Mark , Haydon Andrew , Shackleton Mark , Mar Victoria J. 
Published: December 2022

AbstractBackgroundRecommendations for surveillance imaging for resected melanoma vary considerably. This study examined the utility of imaging in patients with a high‐risk primary melanoma undergoing a protocolized imaging schedule.MethodsThis retrospective study involved data collection regarding imaging, recurrence, and outcome characteristics for patients referred to the Victorian Melanoma Service from January 2016–April 2020 and managed for resected stage IIC or III melanoma. Patients with a T4b tumor who did not undergo a sentinel lymph node biopsy were included (T4bNX). Recurrences were “clinically detected” if they were primarily detected by patient symptoms or physical examination, or ‘imaging‐detected’ if the patient was asymptomatic. Cox regression models including time‐varying co‐variates were used to assess the impact of imaging‐detected versus clinically‐detected recurrence on overall survival.ResultsOver a median follow‐up time of 2.7 years, 199 patients underwent surveillance imaging (T4bNX:22, IIC:33, IIIA:22, IIIB:60, IIIC:61, IIID:1), and 44% (n = 88) experienced disease recurrence. Imaging detected over half (53%) of all recurrences. In adjusted analyses, mortality risk was reduced after an imaging‐detected compared to clinically‐detected recurrence at any given time from the start of surveillance (hazard ratio 0.25, 95% confidence interval 0.10–0.66, p = .005).ConclusionOur study indicates that routine imaging in the early follow‐up period of resected T4bNX, stage IIC and III melanoma plays an important role in the detection of asymptomatic recurrences. Imaging‐detected recurrence may be associated with a survival benefit and studies with more prolonged follow‐up are required to confirm these findings.