bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reemergence of Marburgvirus disease: Update on current control and prevention measures and review of the literature
Authors: Elsheikh Randa , Makram Abdelrahman M. , Selim Hager , Nguyen Dung , Le Thi Thu Thao , Tran Van‐Phu , Elaziz Khader Sarah Abd , Huy Nguyen Tien 
Published: May 2023

AbstractIn 1967, the very first case of the Marburgvirus disease (MVD) was detected in Germany and Serbia sequentially. Since then, MVD has been considered one of the most serious and deadly infectious diseases in the world with a case‐fatality rate between 23% and 90% and a substantial number of recorded deaths. Marburgvirus belongs to the family of Filoviridae (filoviruses), which causes severe viral hemorrhagic fever (VHF). Some major risk factors for human infections are close contact with African fruit bats, MVD‐infected non‐human primates, and MVD‐infected individuals. Currently, there is no vaccine or specific treatment for MVD, which emphasizes the seriousness of this disease. In July 2022, the World Health Organization reported outbreaks of MVD in Ghana after two suspected VHF cases were detected. This was followed in February and March 2023 with the emergence of the virus in two countries new to the virus: Equatorial Guinea and Tanzania, respectively. In this review, we aim to highlight the characteristics, etiology, epidemiology, and clinical symptoms of MVD, along with the current prevention measures and the possible treatments to control this virus.
Bipartite synchronization of multi‐agent systems under deception attacks via pinning delayed‐impulsive control
Authors: Dai Hongyun , Guo Xing , Ji Lianghao , Li Huaqing 
Published: May 2023

AbstractThis article aims to investigate the bipartite synchronization problem of multi‐agent systems (MASs) under deception attacks. A pinning delayed‐impulsive control scheme is proposed to solve the synchronization of MASs under deception attacks that modify the transmitted data information and destroy the data integrity. The time delay can have a gain effect on the stability of the system by using time delay utilization technology. By selecting the appropriate time delay parameters, the convergence speed of the system is effectively improved. Furthermore, cooperative and competitive interactions between agents are considered. Sufficient conditions of the bipartite mean‐square bounded synchronization of MASs under deception attacks are theoretically obtained. Finally, the designed numerical simulations illustrate the correctness and effectiveness of our results.
Influence of the Camphor Sulphonic Acid (CSA) Intercalation on the Micro‐structural and Gas Sensing Properties of Polyaniline‐CeO2 Nanohybrid for NH3 Gas Detection
Authors: Dhanawade Reshma N. , Pawar Nanasaheb S. , Chougule Manik A. , Hingangavkar Gajanan M. , Nimbalkar Tanaji M. , Chavan Ganesh T. , Jeon Chan‐Wook , Patil Vikas B. 
Published: May 2023

AbstractDeveloping a high performance sensing materials operating at room temperature (30 °C) is eminently a challenging task. The facile chemical oxidative polymerization route was employed for the synthesis of PAni‐CeO2 nanohybrids with CSA intercalation (10–50 wt %) on the chains of protonated PAni. The cubic crystal structure of PAni‐CeO2‐CSA nanohybrids were revealed by X‐ray diffractometry (XRD). Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were employed for the structural and morphological investigations. X‐ray Photoelectron Spectroscopy (XPS) and Raman spectroscopy confirmed the formation of PAni‐CeO2‐CSA nanohybrid. The consequences of CSA intercalation on the gas sensing performance of PAni‐CeO2 nanohybrids are explored through custom designed sensing system. The gas sensing investigations revealed that PAni‐CeO2‐CSA (50 wt %) nanohybrid exhibited highest response (93 %) towards 100 ppm NH3 at 30 °C. Advantageously, CSA intercalated PAni‐CeO2 nanohybrid gas sensor delivered fast response and quick recovery (8 sec and 482 sec) with admirable stability (84.09 %) towards NH3 at 30 °C.
Design and Synthesis of Benzenesulfonamides Coupled with Piperidine, Morpholine, and N,N‐Dimethylethanamine Moieties as Apoptotic Inducers through VEGFR2 and Topoisomerase II Inhibition
Authors: Albujuq Nader R. , Althumayri Khalid , Alharbi Reem A. K , Al‐Karmalawy Ahmed A. , Nafie Mohamed S. 
Published: May 2023

AbstractNovel hybrid series of benzenesulfonamide coupled with piperidine, morpholine, and N,N‐dimethylethanamine moieties at sulfonyl group were designed through pharmacophore hybridization, synthesized, and evaluated for cancer treatment. Benzenesulfonamide‐based derivatives had been synthesized, structurally elucidated, and biologically evaluated as potent VEGFR2 kinase and topoisomerase II inhibitors with cytotoxicity against MCF‐7 and HepG2 cells. Interestingly, the most cytotoxic compound against MCF‐7 and HepG2 cells exhibited promising IC50 values of 0.08 and 0.186 μM, respectively, compared to Doxorubicin as the reference drug with IC50 values of 7.67 and 8.28 μM. It exhibited promising dual enzyme inhibition VEGFR2 and Topoisomerase II with IC50 values of 13.24 nM and 8.3 μM compared to Sorafenib and Doxorubicin as standard drugs. It significantly stimulated total apoptotic breast cancer cell death by 55.25‐fold (34.26 % compared to 0.62 for the control), arresting the cell cycle at S‐phase, which affected the apoptosis‐mediated genes through upregulating P53, Bax, caspases 3, 8, and 9 and downregulating the anti‐apoptotic gene Bcl‐2. A molecular docking study was conducted to confirm the binding affinity of the designed compounds towards VEGFR2 and Topoisomerase II proteins with good binding energy and interactive modes as their co‐crystallized ligands.
Rapid Single‐Round Pool Testing of Infectious Disease Enabled by Multicolor Digital Melting PCR
Authors: Cui Xu , Ngang Shaun , Liu Dong Dong , Cheow Lih Feng 
Published: May 2023

AbstractPooled nucleic acid amplification test is a promising strategy to reduce cost and resources for screening large populations for infectious disease. However, the benefit of pooled testing is reversed when disease prevalence is high, because of the need to retest each sample to identify infected individual when a pool is positive. Split, Amplify, and Melt analysis of Pooled Assay (SAMPA) is presented, a multicolor digital melting PCR assay in nanoliter chambers that simultaneously identify infected individuals and quantify their viral loads in a single round of pooled testing. This is achieved by early sample tagging with unique barcodes and pooling, followed by single molecule barcode identification in a digital PCR platform using a highly multiplexed melt curve analysis strategy. The feasibility is demonstrated of SAMPA for quantitative unmixing and variant identification from pools of eight synthetic DNA and RNA samples corresponding to the N1 gene, as well as from heat‐inactivated SARS‐CoV‐2 virus. Single round pooled testing of barcoded samples with SAMPA can be a valuable tool for rapid and scalable population testing of infectious disease.
Engineered Cytokine‐Primed Extracellular Vesicles with High PD‐L1 Expression Ameliorate Type 1 Diabetes
Authors: Wang Lanxing , Qi Chunxiao , Cao Hongmei , Zhang Yanwen , Liu Xing , Qiu Lina , Wang Hang , Xu Lijuan , Wu Zhenzhou , Liu Jianfeng , Wang Shusen , Kong Deling , Wang Yuebing 
Published: May 2023

AbstractType 1 diabetes (T1D), which is a chronic autoimmune disease, results from the destruction of insulin‐producing β cells targeted by autoreactive T cells. The recent discovery that mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) function as therapeutic tools for autoimmune conditions has attracted substantial attention. However, the in vivo distribution and therapeutic effects of MSC‐EVs potentiated by pro‐inflammatory cytokines in the context of T1D have yet to be established. Here, it is reported that hexyl 5‐aminolevulinate hydrochloride (HAL)‐loaded engineered cytokine‐primed MSC‐EVs (H@TI‐EVs) with high expression of immune checkpoint molecule programmed death‐legend 1 (PD‐L1) exert excellent inflammatory targeting and immunosuppressive effects for T1D imaging and therapy. The accumulated H@TI‐EVs in injured pancreas not only enabled the fluorescence imaging and tracking of TI‐EVs through the intermediate product protoporphyrin (PpIX) generated by HAL, but also promoted the proliferative and anti‐apoptotic effects of islet β cells. Further analysis revealed that H@TI‐EVs exhibited an impressive ability to reduce CD4+ T cell density and activation through the PD‐L1/PD‐1 axis, and induced M1‐to‐M2 macrophage transition to reshape the immune microenvironment, exhibiting high therapeutic efficiency in mice with T1D. This work identifies a novel strategy for the imaging and treatment of T1D with great potential for clinical application.
In‐Situ Fabrication of Sustainable‐N‐Doped‐Carbon‐Nanotube‐Encapsulated CoNi Heterogenous Nanocomposites for High‐Efficiency Electromagnetic Wave Absorption
Authors: Zhang Xue , Tian Xuelei , Qiao Jing , Fang Xinrui , Liu Kaiye , Liu Chang , Lin Jingpeng , Li Lutong , Liu Wei , Liu Jiurong , Zeng Zhihui 
Published: May 2023

AbstractDeveloping carbon encapsulated magnetic composites with rational design of microstructure for achieving high‐performance electromagnetic wave (EMW) absorption in a facile, sustainable, and energy‐efficiency approach is highly demanded yet remains challenging. Here, a type of N‐doped carbon nanotube (CNT) encapsulated CoNi alloy nanocomposites with diverse heterostructures are synthesized via the facile, sustainable autocatalytic pyrolysis of porous CoNi‐layered double hydroxide/melamine. Specifically, the formation mechanism of the encapsulated structure and the effects of heterogenous microstructure and composition on the EMW absorption performance are ascertained. With the presence of melamine, CoNi alloy emerges its autocatalysis effect to generate N‐doped CNTs, leading to unique heterostructure and high oxidation stability. The abundant heterogeneous interfaces induce strong interfacial polarization to EMWs and optimize impedance matching characteristic. Combined with the inherent high conductive and magnetic loss capabilities, the nanocomposites accomplish a high‐efficiency EMW absorption performance even at a low filling ratio. The minimum reflection loss of −84.0 dB at the thickness of 3.2 mm and a maximum effective bandwidth of 4.3 GHz are obtained, comparable to the best EMW absorbers. Integrated with the facile, controllable, and sustainable preparation approach of the heterogenous nanocomposites, the work shows a great promise of the nanocarbon encapsulation protocol for achieving lightweight, high‐performance EMW absorption materials.
Navigating wasta in business practices in Lebanon
Authors: Helal Rima Y. , Ali Sa'ad , Strecker Sophie , Weir David 
Published: May 2023

AbstractFaced with severe social, political, and economic challenges, Lebanon is described as a weak state. Argued to be a key factor weakening the formal institutions there, is the prevalent practice of wasta. This article seeks to answer two questions: (1) Why is wasta prevalent in a business environment characterised by weak formal institutions, such as Lebanon? (2) How can managers navigate the use of wasta in the Lebanese business context where it prevails, avoiding its negative outcomes while utilizing its positive outcomes? Fourteen semi‐structured interviews were conducted of managers from the Lebanese industrial sector. The findings highlight that wasta is used due to the networked nature of Lebanese society, economic hardship, widespread corruption and to maintain power. It was found that wasta could be beneficial in securing jobs, removing red tape, and gaining employment for humanitarian reasons. Finally, the negative outcomes of using wasta were found to include the employment of unqualified individuals, a reduction of organizations' productivity and a further weakening of formal institutions.
Exosome‐derived miR‐142‐5p from liver stem cells improves the progression of liver fibrosis by regulating macrophage polarization through CTSB
Authors: Hu Zongqiang , Zhao Yingpeng , Jiang Jie , Li Wang , Su Gang , Li Li , Ran Jianghua 
Published: May 2023

AbstractBackgroundThis study aims to explore the effect of liver stem cells (LSCs)‐derived exosomes and the miR‐142a‐5p carried by them on the process of fibrosis by regulating macrophages polarization.MethodsIn this study, CCL4 was used to establish liver fibrosis model. The morphology and purity of exosomes (EVs) were verified by transmission electron microscopy, western blotting (WB) and nanoparticle tracing analysis (NTA). Real‐time quantitative PCR (qRT‐PCR), WB and enzyme‐linked immunoadsorption (ELISA) were used to detect liver fibrosis markers, macrophage polarization markers and liver injury markers. Histopathological assays were used to verify the liver injury morphology in different groups. The cell co‐culture model and liver fibrosis model were constructed to verify the expression of miR‐142a‐5p and ctsb.ResultsImmunofluorescence of LSCs markers CK‐18, epithelial cell adhesion molecule (EpCam), and AFP showed that these markers were up‐regulated in LSCs. In addition, we evaluated the ability of LSCs to excrete EVs by labeling LSCs‐EVs with PKH67. We found that CCL4 and EVs were simultaneously treated at 50 and 100 μg doses, and both doses of EVs could reduce the degree of liver fibrosis in mice. We tested markers of M1 or M2 macrophage polarization and found that EVs reduced M1 marker expression and promoted M2 marker expression. Further, ELISA was used to detect the secreted factors related to M1 and M2 in tissue lysates, which also verified the above views. Further analysis showed that the expression of miR‐142a‐5p increased significantly with the increase of EVs treatment concentration and time. Further, in vitro and in vivo LSCs‐EVs regulate macrophage polarization through miR‐142a‐5p/ctsb pathway and affect the process of liver fibrosis.ConclusionOur data suggest that EVs‐derived miR‐142‐5p from LSCs improves the progression of liver fibrosis by regulating macrophage polarization through ctsb.
RETRACTED: Erianin suppressed lung cancer stemness and chemotherapeutic sensitivity via triggering ferroptosis
Authors: Lv Jian , Wang Ze , Liu Hongchao 
Published: May 2023

AbstractThe previous research has focused on the suppressive effects of Erianin on tumor progression, but its impact on cancer stemness has not been reported. This study aimed to investigate the effects of Erianin on lung cancer stemness. First, we screened various concentrations Erianin to ensure that it did not affect lung cancer cell viability. Subsequently, we found that Erianin significantly attenuated lung cancer stemness through various analyses, including qRT‐PCR, western blot, sphere‐formation, and ALDH activity detection. Furthermore, Erianin was shown to enhance chemosensitivity of lung cancer cells. Mechanistically, three inhibitors (cell apoptosis inhibitor, necrosis inhibitor, and ferroptosis inhibitor) were added into lung cancer cells with Erianin treatment, respectively, and we found that Erianin mainly suppressed lung cancer stemness through ferroptosis. Taken together, this study reveals that Erianin has the potential to suppress lung cancer stemness and could be a valuable chemotherapeutic enhancer for lung cancer.
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide‐induced inhibition of malignant growth in hepatocellular carcinoma cells
Authors: Yu Haiyan , Hao Zhiwei , Liu Xuemin , Wei Zhixuan , Tan Renming , Liu Xiaotian , Chen Qiongxia , Chen Ying , Zhou Hongyan , Liu Yuchen , Fu Zhengqi 
Published: May 2023

AbstractDiallyl sulfide (DAS), as a major component of garlic extracts, has been shown to inhibit growth of hepatocellular carcinoma cells (HCC), but the underlying mechanism is still elusive. In this study, we aimed to explore the involvement of autophagy in DAS‐induced growth inhibition of HepG2 and Huh7 hepatocellular carcinoma cells. We studied growth of DAS‐treated HepG2 and Huh7 cells using the MTS and clonogenic assays. Autophagic flux was examined by immunofluorescence and confocal microscopy. The expression levels of autophagy‐related proteins AMPK, mTOR, p62, LC3‐II, LAMP1, and cathepsin D in the HepG2 and Huh7 cells treated with DAS as well as the tumors formed by HepG2 cells in the nude mice in the presence or absence of DAS were examined using western blotting and immunohistochemistry analysis. We found that DAS treatment induced activation of AMPK/mTOR, and accumulation of LC3‐II and p62 both in vivo and in vitro. DAS inhibited autophagic flux through blocking the fusion of autophagosomes with lysosomes. Furthermore, DAS induced an increase in lysosomal pH and inhibition of Cathepsin D maturation. Co‐treatment with an autophagy inhibitor (Chloroquine, CQ) further enhanced the growth inhibitory activity of DAS in HCC cells. Thus, our findings indicate that autophagy is involved in DAS‐mediated growth inhibition of HCC cells both in vitro and in vivo.
Role of dipole relaxation in measuring electric polarization in type‐II multiferroics
Authors: Kumar Rahul , Sundaresan A. 
Published: May 2023

AbstractType‐II multiferroics typically have significantly lower polarization values compared to type‐I multiferroics. As a result, pyrocurrent measurements are often employed to estimate their electric polarization. However, when the magnitude of the pyrocurrent is overshadowed by faster dipole relaxation and thermally stimulated free charge carriers, the method becomes inadequate. Here, we demonstrate the effectiveness of the DC bias current technique in overcoming the limitation of pyroelectric current measurement using two examples. Our findings reveal that the DC bias current signal is more sensitive than pyroelectric current measurements and can be used to characterize a type‐II multiferroic material, quantitatively and qualitatively, with small polarization. Additionally, we discuss the role of dipole relaxation rate in measuring electric polarization and explain it in terms of dipolar interaction and thermal energy.
Transferring Knowledge from Academia to the Companies: A New Method
Authors: Cazón-Martin Aitor 
Published: May 2023

AbstractCollaboration between Academia and Industry must be considered as a path to innovation through the exchange of knowledge. Although this collaboration has existed for years by presenting and publishing together new methods in journals or conferences or through lectures or workshops taught by professionals with a focus on daily problems, differences in goals and timing are found as barriers for knowledge transfer. In an ideal scenario, this collaboration should lead to a win-to-win situation where companies increase competitiveness as it facilitates the integration and commercialization of new knowledge in their products, while Academia can obtain new research directions and additional financial power. In a real scenario, despite the efforts made to successfully carry out this transfer, there is still work to be done, since the literature shows that current methods used by Academia are not entirely working. In this chapter, the first section contains a review of published documentation that reflect the different practices that are being carried out for the transfer of knowledge between Academia and Industry to understand the current procedures for transferring knowledge, as well as the main channels used, and the barriers identified. The second section describes the new method or guide to facilitate this unidirectional knowledge transfer from Academia to Industry, especially when working with Emerging Materials and Technologies (EM&T). This method combines a Learning stage—to explain the fundamentals about the EM&Ts—and an Applying phase to explain specific strategies of how to come up with ideas to find new opportunities that link the emerging EM&T and the company’s product strategy.
Applying DATEMATS Methods and Tools to Advanced Growing Materials: Ideating Material Value Streams Through Symbiotic Growth of Production Residues and Microbes
Authors: Pasold Anke 
Published: May 2023

AbstractThis chapter documents the Interdisciplinary Design Challenge on Advanced Growing Materials organized by the Material Design Lab at the Copenhagen School of Design and Technology (KEA). It was to try the framework, tools, and didactic materials developed in the DATEMATS project on the ideation with microorganisms by relating and merging the former with Material Design Lab’s employed didactic and creative takes. It was to answer how to firstly ideate with something that is invisible to the eye, that one needs to understand, collaborate with, and care for to achieve successful outcomes, and that needs time to create the final material and respective form before and while it secondly is being applied and how this thirdly could be successfully implemented in the application search in a real-life context with no prior knowledge and within a minimal time frame. In the following, the considerations behind the curation of both brief and schedule that would enable this merge are laid out. Typically employed tools and methods are related to the DATEMATS tools and methods, presented and argued for, and the five results are explored considering the Design Challenge’s set goals. The below discussions utilize a three-way informed evaluation based on (1) on-site observation, photo, and video documentation with subsequent protocol studies (Dorst and Cross, Des Stud 22:425–437, 2001) combined with notes and conclusions drawn from supervision as well as result evaluation, (2) direct feedback by the students through the conducted survey, and (3) the feedback received by the company. Combined, they give clear indications of the frame’s potential and limitations when working with EM&Ts like Advanced Growing Materials and a view to following iteration improvements and further integration.
Applying DATEMATS Methods and Tools to Experimental Wood-Based Materials: Materiality in an Ideation Process
Authors: Laamanen Tarja-Kaarina , Kääriäinen Pirjo 
Published: May 2023

AbstractThis chapter provides an overview of the DATEMATS Experimental wood-based materials workshop and student projects, and a more detailed description of one team's ideation process. The workshop was held at the Chemarts facilities of Aalto University, Finland, in January 2022. A total of 19 students from four different universities and from the fields of design and engineering participated in a five-day workshop creating innovative applications for interior panels made of cellulose waste. The company challenge was given by Honext from Spain.