bluuebunny/crossref_metadata_2025_split huggingface dataset:
ProxyVis—A Proxy for Nighttime Visible Imagery Applicable to Geostationary Satellite Observations
Authors: Chirokova Galina , Knaff John A. , Brennan Michael J. , DeMaria Robert T. , Bozeman Monica , Stevenson Stephanie N. , Beven John L. , Blake Eric S. , Brammer Alan , Darlow James W. , DeMaria Mark , Miller Steven D. , Slocum Christopher J. , Molenar Debra , Hillger Donald W. 
Published: August 2023

Abstract
Visible satellite imagery is widely used by operational weather forecast centers for tropical and extratropical cyclone analysis and marine forecasting. The absence of visible imagery at night can significantly degrade forecast capabilities, such as determining tropical cyclone center locations or tracking warm-topped convective clusters. This paper documents ProxyVis imagery, an infrared-based proxy for daytime visible imagery developed to address the lack of visible satellite imagery at night and the limitations of existing nighttime visible options. ProxyVis was trained on the VIIRS day/night band imagery at times close to the full moon using VIIRS IR channels with closely matching GOES-16/17/18, Himawari-8/9, and Meteosat-9/10/11 channels. The final operational product applies the ProxyVis algorithms to geostationary satellite data and combines daytime visible and nighttime ProxyVis data to create full-disk animated GeoProxyVis imagery. The simple versions of the ProxyVis algorithm enable its generation from earlier GOES and Meteosat satellite imagery. ProxyVis offers significant improvement over existing operational products for tracking nighttime oceanic low-level clouds. Further, it is qualitatively similar to visible imagery for a wide range of backgrounds and synoptic conditions and phenomena, enabling forecasters to use it without special training. ProxyVis was first introduced to National Hurricane Center (NHC) operations in 2018 and was found to be extremely useful by forecasters becoming part of their standard operational satellite product suite in 2019. Currently, ProxyVis implemented for GOES-16/18, Himawari-9, and Meteosat-9/10/11 is being used in operational settings and evaluated for transition to operations at multiple NWS offices and the Joint Typhoon Warning Center.

Significance Statement
This paper describes ProxyVis imagery, a new method for combining infrared channels to qualitatively mimic daytime visible imagery at nighttime. ProxyVis demonstrates that a simple linear regression can combine just a few commonly available infrared channels to develop a nighttime proxy for visible imagery that significantly improves a forecaster’s ability to track low-level oceanic clouds and circulation features at night, works for all current geostationary satellites, and is useful across a wide range of backgrounds and meteorological scenarios. Animated ProxyVis geostationary imagery has been operational at the National Hurricane Center since 2019 and is also currently being transitioned to operations at other NWS offices and the Joint Typhoon Warning Center.
Patient knowledge and preferences for peripheral artery disease treatment
Authors: Smolderen Kim G , Romain Gaëlle , Gosch Kensey , Arham Ahmad , Provance Jeremy B , Spertus John A , Poosala Anwesh B , Shishehbor Mehdi H. , Safley David , Scott Kate , Stone Nancy , Mena-Hurtado Carlos 
Published: August 2023

Background: Shared medical decision making requires patients’ understanding of their disease and its treatment options. Peripheral artery disease (PAD) is a condition for which preference-sensitive treatments are available, but for which little is known about patients’ knowledge and treatment preferences as it relates to specific treatment goals. Methods: In a prospective, multicenter registry that involved patients with PAD experiencing claudication, the PORTRAIT Knowledge and Preferences Survey was administered at 1 year. It asks questions about PAD treatment choices, symptom relief options, disease management, and secondary prevention. PAD treatment preferences were also queried, and patients ranked 10 PAD treatment goals (1–10 Likert scale; 10 being most important). Results: Among 281 participants completing the survey (44.8% women, mean age 69.6 ± 9.0 years), 54.1% knew that there was more than one way to treat PAD symptoms and 47.1% were offered more than one treatment option. Most (82.4%) acknowledged that they had to manage their PAD for the rest of their life. ‘Avoid loss of toes or legs,’ ‘decreased risk of heart attack/stroke,’ ‘long-lasting treatment benefit,’ ‘living longer,’ ‘improved quality of life,’ and ‘doing what the doctor thinks I should do’ had mean ratings > 9.0 (SD ranging between 1.21 and 2.00). More variability occurred for ‘avoiding surgery.’ ‘cost of treatment,’ ‘timeline of pain relief,’ and ‘return to work’ (SD ranging between 2.76 and 3.58). The single most important treatment goal was ‘improving quality of life’ (31.3%). Conclusions: Gaps exist in knowledge for patients with PAD who experience claudication, and there is a need for increased efforts to improve support for shared decision-making frameworks for symptomatic PAD. (ClinicalTrials.gov Identifier: NCT01419080)
Removal of indoor aerosol particles generated in a medically relevant space using a portable airborne particle filtration device
Authors: Carroll Gregory T , Kirschman David L 
Published: August 2023

Aerosol generating procedures expose operating room personnel to pathogens. Applying localized negative pressure within the proximity of a patient’s airway is expected to reduce the amount of bioaerosols dispersed within the vicinity of a healthcare worker applying an aerosol generating procedure. Nebulized saline was used as a proxy for bioaerosols and was produced with an aerosol generator placed near the centre of a simulated operating room. A particle counter was placed nearby to detect aerosols and determine their size distribution. A portable filtration unit was placed at fixed distances from the site of aerosol emittance to reduce the concentration of aerosols. In the presence of vacuum at distances of 10, 20, 30 and 40 cm from the site of aerosol emittance, the reduction in the average concentrations of 0.5, 0.7, 1.0 and 3.0 μm particles relative to the control ranged from 87 to 99% depending on the distance and particle size. The efficiency of particle capture was dependent on the distance of the vacuum inlet to the aerosol outlet. At all distances tested, significant aerosol reduction was observed ( p < 0.05), indicating that the portable filtration unit has the potential to increase safety without contacting the patient.
Comparison of pipeline embolization device, flow re-direction endoluminal device and surpass flow diverters in the treatment of intracerebral aneurysms
Authors: Field Nicholas C. , Custozzo Amanda , Gajjar Avi A , Dalfino John C. , Boulos Alan S. , Paul Alexandra R. 
Published: August 2023

Objectives The use of flow diversion for the treatment of intracranial aneurysms has gained broad acceptance. Three flow-diverting stents are approved by the Food and Drug Administration for use in the United States. We sought to compare the outcomes and safety profiles between the three devices at our institution. Methods A retrospective review of aneurysms treated with pipeline embolization device (PED), flow re-direction endoluminal device (FRED), and SURPASS was performed for aneurysms treated between 2018 and 2022 at our institution. Results The study cohort consisted of 142 patients. Precisely, 86 aneurysms were treated with a pipeline, 33 aneurysms were treated with FRED, and 23 aneurysms were treated with SURPASS. The 1-year complete occlusion rates were 59.4%, 60%, and 65%, respectively (0.91). Linear regression models found that only adjunctive coiling predicted aneurysm occlusion at 6 months ( p = 0.02), but this effect was lost at 1 year and beyond. There was no significant difference in acute thrombotic or acute hemorrhagic complications between the three cohorts. There was a higher rate of delayed hemorrhagic complications in the SURPASS cohort (10%) compared to the PED (1.3%) and FRED (0%) cohorts ( p = 0.04). There was also a higher rate of in-stent stenosis in the SURPASS cohort (20%) compared to the PED (5%) and FRED (3.1%) cohorts ( p < 0.01). Conclusions Treatment with PED, FRED, and SURPASS all resulted in similar complete occlusion rates at 6 months and 1 year. SURPASS was associated with higher in-stent stenosis as well as delayed hemorrhagic complications. Additional future studies evaluating the newest generation of flow-diverting stents with long-term follow-up will be necessary to make any definitive conclusions.
The OptimaMed intervention to reduce medication burden in nursing home residents with severe dementia: results from a pragmatic, controlled study
Authors: Kröger Edeltraut , Wilchesky Machelle , Morin Michèle , Carmichael Pierre-Hugues , Marcotte Martine , Misson Lucie , Plante Jonathan , Voyer Philippe , Durand Pierre 
Published: August 2023

Abstract
Background
Nursing home (NH) residents with severe dementia use many medications, sometimes inappropriately within a comfort care approach. Medications should be regularly reviewed and eventually deprescribed. This pragmatic, controlled trial assessed the effect of an interprofessional knowledge exchange (KE) intervention to decrease medication load and the use of medications of questionable benefit among these residents.

Methods
A 6-month intervention was performed in 4 NHs in the Quebec City area, while 3 NHs, with comparable admissions criteria, served as controls. Published lists of “mostly”, “sometimes” or “exceptionally” appropriate medications, tailored for NH residents with severe dementia, were used. The intervention included 1) information for participants’ families about medication use in severe dementia; 2) a 90-min KE session for NH nurses, pharmacists, and physicians; 3) medication reviews by NH pharmacists using the lists; 4) discussions on recommended changes with nurses and physicians. Participants’ levels of agitation and pain were evaluated using validated scales at baseline and the end of follow-up.

Results
Seven (7) NHs and 123 participants were included for study. The mean number of regular medications per participant decreased from 7.1 to 6.6 in the intervention, and from 7.7 to 5.9 in the control NHs (p-value for the difference in differences test: < 0.05). Levels of agitation decreased by 8.3% in the intervention, and by 1.4% in the control NHs (p = 0.026); pain levels decreased by 12.6% in the intervention and increased by 7% in the control NHs (p = 0.049). Proportions of participants receiving regular medications deemed only exceptionally appropriate decreased from 19 to 17% (p = 0.43) in the intervention and from 28 to 21% (p = 0.007) in the control NHs (p = 0.22). The mean numbers of regular daily antipsychotics per participant fell from 0.64 to 0.58 in the intervention and from 0.39 to 0.30 in the control NHs (p = 0.27).

Conclusions
This interprofessional intervention to reduce inappropriate medication use in NH residents with severe dementia decreased medication load in both intervention and control NHs, without important concomitant increase in agitation, but mixed effects on pain levels. Practice changes and heterogeneity within these 7 NHs, and a ceiling effect in medication optimization likely interfered with the intervention.

Trial registration
The study is registered at ClinicalTrials.gov: # NCT05155748 (first registration 03–10-2017).
Regional with urban–rural variation in low birth weight and its determinants of Indian children: findings from National Family Health Survey 5 data
Authors: Kundu Ramendra Nath , Ghosh Anushka , Chhetri Birshikha , Saha Indranil , Hossain Md. Golam , Bharati Premananda 
Published: August 2023

AbstractBackgroundLow birth weight is a key indicator for child health, especially a concern in low-middle-income countries. However, health and medically-related reforms are being actively implemented in some middle-income countries like India. Identifying low birth weight (LBW) babies with their determinants across the whole country is essential to formulate regional and area-specific interventions. The objective of this study was to find out the burden and determinants of LBW on the regional and residential (rural–urban) divisions of India.MethodsThe present study was based on the NFHS-5 dataset (2019–21), a nationally representative survey in India. A total of 209,223 births were included in this study. A newborn weighing less than 2500 g was considered as LBW. According to the objectives, we used frequency distribution, chi-square test and binary logistic regression analysis for analysing the data.ResultsAbout 18.24% of the babies were LBW in India, significantly higher in rural areas than in urban areas (18.58% vs 17.36%). Regionally prevalence was more frequent in western (20.63%) and central (20.16%) rural areas. Regarding maternal concerns, in the eastern and southern regions of India, mothers aged 25–34 were less likely to have LBW children than mothers aged 35–49 years. It was found that the risk of LBW was more likely among the children born out of unintended pregnancies in almost all regions except for eastern part. In rural India, women who delivered children at home were more likely to have LBW children in India (AOR = 1.19, CI: 1.12–1.28,p < 0.001) and its central, northern, and southern regions than those who gave birth in institutions. The study indicates that LBW coexists with lower maternal education levels and poor household wealth index across all regions. About 58% and 57% of cumulative effects of independent variables on LBW can be distinguished in urban and rural India, respectively.ConclusionsTargeted-specific strategies need to be undertaken as per region and geographical variations. Then only India should be able to decline LBW as proposed by National Health Policy.
Cuproptosis related gene PDHB is identified as a biomarker inversely associated with the progression of clear cell renal cell carcinoma
Authors: Wang Hu , Yang Zhan , He Xingyu , Guo Fengran , Sun Hao , Xu Sen , Xu Chao , Wang Zhu , Wen Hongzhuang , Teng Zhihai , Wang Yaxuan , Han Zhenwei 
Published: August 2023

Abstract
Background
Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. Pyruvate dehydrogenase E1 subunit beta (PDHB) is one of the cuproptosis genesand is a nuclear-encoded pyruvate dehydrogenase, which catalyzes the conversion of pyruvate to acetyl coenzyme A. However, the mechanism of PDHB in clear cell renal cell carcinoma (ccRCC) remains unclear.

Methods
We used data from TCGA and GEO to assess the expression of PDHB in normal and tumor tissues. We further analyzed the relationship between PDHB and somatic mutations and immune infiltration. Finally, we preliminarily explored the impact of PDHB on ccRCC.

Results
The expression level of PDHB was lower in tumor tissue compared with normal tissue. Meanwhile, the expression level of PDHB was also lower in high-grade tumors than low-grade tumors. PDHB is positively correlated with prognosis in ccRCC. Furthermore, PDHB may be associated with decreased risk of VHL, PBRM1 and KDM5C mutations. In 786-O cells, copper chloride could promote the expression of cuproptosis genes (DLAT, PDHB and FDX1) and inhibit cell growth. Last but not least, we found that PDHB could inhibit the proliferation and migration of ccRCC cells.

Conclusion
Our results demonstrated that PDHB could inhibit the proliferation, migration and invasion in ccRCC cells, which might be a prognostic predictor of ccRCC. Targeting this molecular might provide a new therapeutic strategy for patients with advanced ccRCC.
Pterygium combined with corneal perforation: a case report
Authors: Yang Tianqi , Chan Sun Yuet , Liu Jie , Chen Zhiwei , Yu Guocheng , He Xiaojuan , Meng Jing 
Published: August 2023

Abstract
Background
Pterygium is a common ocular surface disease. Pterygium combined with corneal perforation is rare.

Case presentation
A 28-year-old female patient visited our outpatient clinic due to sudden onset of blurred vision and increased tearing in her left eye. The visual acuity was 1.0 OD and intraocular pressure (IOP) of 19.5 mmHg for the right eye with no significant abnormalities found in the anterior and posterior segments. The visual acuity of her left eye was 0.06, and IOP was 6.2 mmHg. A triangular vascular membranous tissue was seen in her left eye below the nose growing into the cornea and the pupil area was not touched. Slit-lamp examination revealed a tiny round corneal perforation in 8 o’clock position of the lesion area. Hospital diagnosis was given as pterygium combined with corneal perforation. The patient was treated with levofloxacin eye drops and autologous serum-based eye drops.

Conclusions
We report a rare case of pterygium combined with corneal perforation. Perforation is a very rare complication of pterygium. This patient received proper treatment and good result was seen. This article aimed to improve clinicians’ understanding of pterygium.
Pulmonary hypertension— a novel phenotypic hypothesis of Kabuki syndrome: a case report and literature review
Authors: Deng Xiao-xian , Jin Bo-wen , Li Shan-shan , Zhou Hong-mei , Shen Qun-shan , Li Yun-yan 
Published: August 2023

Abstract
Background
Pediatric pulmonary hypertension (PH) is a serious and rare disease that is often derived from genetic mutations. Kabuki syndrome (KS) is a chromosomal abnormality disease that has its origin in the mutation of lysine methyltransferase 2D(KMT2D). Recent evidence has shown that KMT2D mutations are associated with pediatric pulmonary disorders. However, the relationship between the clinical courses of PH and the KMT2D mutation is reported in extremely few cases. Therefore, in this paper, a case was presented and previous literature was reviewed for better understanding of the correlation between pediatric PH and KMT2D mutations.

Case presentation
A 3-year-old girl was transferred to our center for severe cough, shortness of breath, fatigue and fever. Physical examination revealed facial deformities and growth retardation. Echocardiography showed a small atrial septal defect (ASD), and right heart catheterization indicated a significant increase in pulmonary vascular pressure and resistance. The genetic test suggested that she had a KMT2D gene mutation. The patient was finally diagnosed with KS. She was given targeted drugs to reduce pulmonary vascular pressure, but the effect was unsatisfactory.

Conclusions
KS can be complicated with multiple organ malformations and dysfunction. With the progress of next generation sequencing, an increasing number of new phenotypes related to KMT2D mutations have been reported. A bold hypothesis is proposed in this article, that is, PH may be a new phenotype associated with KMT2D mutations. It is suggested that KS and PH should be differentiated from each other to avoid delayed diagnosis and treatment in clinical practice. There is no specific drug for KS treatment. The prognosis of children with inherited PH is usually poor, and lung transplantation may increase their survival rates.
Decisional conflict, caregiver mastery, and depression among Chinese parental caregivers of children with leukemia
Authors: Liu Mowen , Tang Weizhou , Zhang Ye , Sun Wenjun , Wang Yang 
Published: August 2023

Abstract
Background
Informal caregivers of children with leukemia can be emotionally and psychiatrically vulnerable when facing difficult treatment decisions (e.g., chemotherapy, targeted therapy, radiation, transplantation). A common behavioral manifestation of decisional conflict is the verbalized expression of uncertainty about which medical treatment plan to take. The study aims to examine the associations between decisional conflict, mastery, and depressive symptoms among parental caregivers of children with leukemia in China. It explored the mediating role of mastery in the relationship.

Methods
A cross-sectional survey design was adopted. A total of 386 parental caregivers were recruited, and 325 valid questionnaires remained. The mean age of caregivers was 37.7 years, and 61.5% caregivers were female. We used Question Format Decisional Conflict Scale to assess decisional conflict, Pearlin’s Mastery Scale to assess mastery, and Center for Epidemiological Studies Depression 10 to assess depressive symptoms. We used mediation analyses to test the mediating effect of mastery.

Results
The total score of decisional conflict scale, along with its dimensions of uncertainty, support, and effective decision were found negatively associated with depressive symptoms. In contrast, the dimension of information and value were not significantly associated with depressive symptoms. Mediation analyses demonstrated the direct effects of overall decisional conflict and uncertainly were fully mediated by mastery, while the direct effect of support and effective decision were partially mediated.

Conclusions
Efforts should be made to alleviate parental caregivers’ decisional conflict and enhance sense of mastery. Particular attention should be paid to the psycho-social support to relieve uncertainties and ineffectiveness in decision making.
Body mass index and cervical cancer screening among women aged 15–69 years in Eswatini: evidence from a population-based survey
Authors: Motsa Mfundi P. S. , Estinfort Wanda , Phiri Yohane V. A. , Simelane Maswati S. , Ntenda Peter A. M. 
Published: August 2023

Abstract
Background
Cervical cancer stands as one of the most prevalent cancer types among women, despite its preventable nature through early screening and vaccination strategies. The link between being overweight or obese and various adverse health outcomes, including an elevated cancer risk, is well established. Within this study, our central objective was to explore the correlation between body mass index (BMI) and cervical cancer screening (CCS) rates. Moreover, we sought to investigate whether socioeconomic status potentially modulates this relationship.

Methods
Our analysis encompassed 1791 respondents who participated in the World Health Organization’s STEPwise approach to noncommunicable disease risk factor surveillance carried out in Eswatini in 2014. We assessed the connection between BMI, along with other determinants, and CCS through both unadjusted and adjusted logistic regression models.

Results
The uptake of CCS was 14.4% and the prevalence of overweight and obesity was estimated at 28.1 and 34.9% respectively. After accounting for other pertinent variables, the likelihood of obtaining CCS was amplified for individuals classified as obese (adjusted odds ratio [aOR] = 1.99, 95% confidence interval [CI] = 1.26–3.12) or overweight (aOR = 1.98, 95% CI = 1.05–3.74). Furthermore, factors such as being separated or divorced (aOR = 2.03, 95% CI = 1.11–3.72) and engaging in regular physical exercise (aOR = 3.02, 95% CI = 1.21–6.02) were associated with increased odds of undergoing CCS.

Conclusions
This study underscores the noteworthy role played by both overweight and obesity, in conjunction with various socioeconomic factors, in shaping CCS patterns among the surveyed women. For Eswatini, targeted interventions aimed at enhancing CCS participation should take into account the multifaceted factors highlighted within this investigation.