bluuebunny/crossref_metadata_2025_split huggingface dataset:
hsa_circ_0006677 suppression of stemness and progression of non-small cell lung cancer by sponging miR-1276-induced ferroptosis in lung cancer stem cells
Authors: Ting-Ting Dai , li lixiu , wang lu , Zhao Yu-Ying , che Shuping , Sun Jie-Xuan , Gao Zhuo , Gao Lu 
Published: August 2023

Abstract
The relationship between circRNAs (circRNAs) and lung cancer stem cells (LCSCs) is uncertain. Screening for relevant circRNAs through the GEO database. We investigated the impact of LCSCs and circRNA (hsa_circ_0006677) in the progression and treatment of NSCLC. We constructed lung CSCs (LCSCs; PC9 and A549). hsa_circ_0006677's role in vitro was determined by cell counting, clone and sphere formation, and Transwell analysis. Metastatic tumor xenograft models and in situ transplant models were established for in vivo analysis. We found that hsa_circ_0006677 was significantly low expressed in NSCLC tissues and LCSCs. hsa_circ_0006677 levels correlated with the stage and survival of NSCLC patients. hsa_circ_0006677 reduced levels decreased tumor cell proliferation, migration, invasion, and stem cell-like properties. Through the TRCirc database and in vivo and in vitro experiments hsa_circ_0006677 was positively regulated by GABPA. Meanwhile, downward continuous exploration by databases such as miRANDA database and validation with in vivo and in vitro experiments demonstrated that silencing of hsa_circ_0006677 was found to downregulate ATF3 expression and its ferroptosis signaling pathway by increasing the sponge effect of miR-1276. Our data demonstrate an important role for hsa_circ_0006677 in the stem cell-like properties of NSCLC cells. The key targets we identified in this signaling pathway, GABPA, hsa_circ_0006677, and miR-1276, may all intervene in the stemness and progression of NSCLC, which may also provide directions and ideas for future clinical treatments.
The Roles of Emotional Adaptability and Stress Regulation on the Enjoyment of Music Listening and Chinese Adults’ Subjective Well-being during the COVID-19 Pandemic
Authors: Zhang Qian , Suh Kyung Hyun 
Published: August 2023

Abstract
Background
This study investigated the relationship between the enjoyment of music listening and subjective well-being among Chinese adults during the COVID-19 Pandemic, and the mediation effect of emotionally adaptive functions of music listening and of stress regulation of music listening in the aforementioned relationship.
Methods
The participants were 277 male and female Chinese adults aged 18–57 years. The mediating effects were analyzed using PROCESS Macro 3.5 Model 4.
Results
The results revealed that the enjoyment of music listening was positively correlated with the emotionally adaptive functions of music listening, stress regulation of music listening, and subjective well-being. Additionally, the emotionally adaptive functions and stress regulation of music listening were positively correlated with subjective well-being. The emotionally adaptive functions of music listening completely mediated the association between enjoyment of music listening and subjective well-being during the COVID-19 Pandemic. However, the stress regulation of music listening did not mediate this relationship.
Conclusion
These findings suggest that music listening can enhance the subjective well-being of Chinese adults through emotionally adaptive functions in stressful situations.
Effect of Neural Vision therapy on uncorrected pseudophakic visual acuity
Authors: Vaitheeswaran Krishna , Kaur Preetinder , Nadar Monika 
Published: August 2023

Abstract
Purpose
The present study was conducted to investigate the effect of neural vision therapy using perceptual learning on near and distance visual acuity in pseudophakic patients with mono-focal intraocular lenses.
Methods
The prospective interventional non-comparative study was conducted on 30 pseudophakic patients who had received mono-focal intraocular lenses and required corrective lenses for optimal visual acuity for distance, near or both. Perceptual learning was performed using Gabor gratings of varying spatial frequency and contrast. The distance and near visual acuity as well as contrast sensitivity was assessed before and after the training. The visual function was monitored for a period of three months after intervention.
Results
The mean age of patients in the study was 68.6 ± 11.05 years and included 16 women and 14 men. There was a significant improvement in distance (0.15 ± 0.13 to 0.05 ± 0.06) and near visual acuity (0.4 ± 0.09 to 0.09 ± 0.07) as well as contrast sensitivity function after the intervention (1.35 ± 0.24 to1.83 ± 0.13). (P < 0.05).
Conclusions
Neural vision therapy using perceptual learning, significantly improved distance and near acuity, as well as contrast sensitivity in pseudophakic patients. With no alteration in the refractive status, perceptual training improved visual function by enhancing neural processing at low signal-noise ratios seen in uncorrected pseudophakic eyes. Neural vision therapy may be an alternative for enhancing visual function across a range of distances without the need for corrective lenses.
Top-k Approximate Selection for TypicalityQuery Results over Spatio-textual Data
Authors: Meng Xiangfu , Zhang Xiaoyan , Huo Hongjin , Leng Qiangkui 
Published: August 2023

Abstract
Spatial keyword query is a classical query processing mode for spatio-textual data, which aims to provide users the spatio-textual objects with the highest spatial proximity and textual similarity to the given query. However, the top-k result objects obtained by using the spatial keyword query mode are often similar to each other while users hope that the system can pick top-k typicality results from the candidate query results in order to make users understand the representative features of the candidate result set. To deal with the problem of typicality analysis and typical object selection of spatio-textual data query results, a typicality evaluation and top-k approximate selection approach is proposed. First, the approach calculates the synthetic distances on dimensions of geographic location, textual semantics, and numeric attributes between all spatio-textual objects. And then, a hybrid index structure that can simultaneously support the location, text, and numeric multi-dimension matching is presented in order to expeditiously obtain the candidate query results. According to the synthetic distances between spatio-textual objects, a Gaussian kernel probability density estimation-based method for measuring the typicality of query results is proposed. To facilitate the query result analysis and top-k typical object selection, the Tournament strategy-based and Local neighborhood-based top-k typical object approximate selection algorithms are presented, respectively. The experimental results demonstrated that the text semantic relevancy measuring method for spatio-textual objects is accurate and reasonable, and the Local neighborhood-based top-k typicality result approximate selection algorithm achieved both the low error rate and high execution efficiency.
Green Synthesis of ZnO and SiO2 Nanoparticles and its potential application on Pineapple Fabric to impart multifunctional properties
Authors: Moniruzzaman Md. , Hussain Syed Zubair , Rahman SM Atikur 
Published: August 2023

Abstract
The present study aims to synthesize ZnO and SiO2 nanoparticles by using the green technique and applied to pineapple fabric to impart multifunctional properties. ZnO nanoparticles were synthesized by using Zinc Acetate where the mixture of Acalypha Indica and Citrus aurantifolia peel powder was used as the catalyst. Also, SiO2 nanoparticles were synthesized from sugarcane bagasse which was the primary source of silica. Final SiO2 nanoparticles were obtained by the addition of NaOH and HNO3. Afterward, the synthesized particles were coated on the pineapple fabric by using the dip-pad-dry-cure method along with the addition of 2 wt% acrylic binder. The structural properties as well as the microstructure and chemistry of these coated samples were characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM) analysis. Also, the UV resistance, resistance against microorganisms, and super-hydrophobicity properties were evaluated by UV/VIS Spectrophotometer analysis, antimicrobial test, and spray rating test accordingly where the nanoparticle coated sample showed a very good absorbency in UV rays, superhydrophobic properties, and a very good resistance against microorganism maintaining optimum tensile.
Regulation of lifespan and proteostasis by sensory neural activity and CaMK
Authors: Yu Yanxun , Zhao Ranran , Ge Weiqi , Xue Weikang , Liu Jiaze , Wang Kaiqi , Jin Youngnam 
Published: August 2023

Abstract
The activity state of the nervous system can influence a wide variety of physiological processes, including lifespan. While the impact of neural activity on ageing and longevity remains a topic of debate, substantial evidence suggests that decreasing overall neural activity is linked to increased longevity in invertebrate and mammalian models. However, the specific neuronal groups and underlying mechanisms involved are not well understood. We investigated the role of the CaM kinase, cmk-1, in the nematode to address this knowledge gap. Strikingly, we found that the eliminating cmk-1 enhances lifespan and improves proteostasis by suppressing excitation in the thermosensory AFD neurons, particularly at elevated temperatures that trigger AFD hyperactivation. Furthermore, genetically reducing hyperactivation specifically in wild-type AFD neurons extends longevity and improves proteostasis, similar to the effects observed in cmk-1 mutant. These beneficial outcomes are attribute to the activation of DAF-16 in the intestine, likely through the release of the INS-1 neuropeptide from the thermosensory neural circuit. Our findings reveal a causal mechanism through which the activity of the sensory neural circuit regulates lifespan and proteostasis, highlighting the pivotal role of CaMK in shaping these processes by regulating neural activity.
Blood-based screening panel for lung cancer based on clonal hematopoietic mutations
Authors: Anandakrishnan Ramu , Shahidi Ryan , Dai Andrew , Antony Veneeth , Zyvoloski Ian J 
Published: August 2023

Abstract
Background
Early detection can significantly reduce mortality due to lung cancer. However, financial, and other barriers for the currently approved screening protocol (low dose computed tomography (CT) scan) have limited its uptake. Presented here is a blood-based screening panel based on clonal hematopoietic mutations. Mutations in tumor cells that inhibit immune destruction have been extensively studied. However, mutations in immune cells that may prevent an effective anti-tumor immune response remain relatively unstudied. Animal model studies suggest that clonal hematopoietic (CH) mutations in tumor infiltrating immune (TII) cells can modulate cancer progression, representing potential predictive biomarkers. The goal of this study was to determine if the clonal expansion of these mutations in blood samples could predict the occurrence of lung cancer.
Methods
A set of 98 potentially pathogenic CH mutations in TII cells were identified using sequencing data from lung cancer samples. These mutations were used as predictors to develop a logistic regression machine learning model. The model was tested on a set of 578 lung cancer and 545 non-cancer samples from 18 independent cohorts.
Results
The logistic regression model correctly classified lung cancer and non-cancer blood samples with 94.12% sensitivity (95% Confidence Interval: 92.20-96.04%) and 85.96% specificity (95% Confidence Interval: 82.98–88.95%). In addition, the model correctly classified 89.98% of lung cancer and 74.86% of non-cancer blood samples with high confidence (prediction probabilities of > 0.9 and < 0.1 for cancer, respectively).
Conclusions
Our results suggest that it may be possible to develop an accurate blood-based lung cancer screening panel. Unlike most other “liquid biopsies” currently under development, the assay presented here is based on standard sequencing protocols and uses a relatively small number of rationally selected mutations as predictors.
Effects of soil on development, survival, and oviposition on Culex quinquefasciatus (Diptera: Culicidae) mosquitoes
Authors: Pautzke Kellen C. , Felsot Allan S. , Reganold John P. , Owen Jeb P. 
Published: August 2023

Abstract
Background
Water quality is known to influence the development and survival of larval mosquitoes, which affects mosquito-borne pathogen transmission as a function of the number of mosquitoes that reach adulthood and can blood feed. Although water properties are known to affect mosquito development, few studies have investigated the link between soil properties, water quality, and mosquito development. Due to the large number of ground breeding mosquito species, this linkage is an important factor to consider in mosquito ecology. In this study, we explored the effects of different soils on multiple life history parameters of the ground breeding mosquito species Culex quinquefasciatus (Diptera: Culicidae).
Methods
Cx. quinquefasciatus larvae were reared in water combined with different soil substrates (sandy, silt, or clay loam textures) at increasing soil to water volume ratios, with and without the addition of organic material (fish food). Gravid mosquitoes were offered soil-water cups to investigate soil effects on oviposition preference.
Results
Without added food, larval survival and development differed significantly among waters with different soils and volumes of substrate. Mosquitoes in clay loam soil water survived longer and developed further than mosquitoes in other soil waters. Adding food significantly reduced the soil effects on larval survival time, development, and pupation. Adult female mosquitoes preferentially chose soil waters with higher clay content for oviposition, and the addition of food significantly reduced the soil effects on oviposition preference.
Conclusions
This study suggests soil composition plays an important role in larval mosquito survival and development, as well as the oviposition preference of gravid females. Future studies may separate abiotic and biotic soil features that affect mosquitoes and link soil variation at the landscape scale to predictions of mosquito population dynamics and mosquito-borne pathogen transmission.
Comparing the effects of selenium-enriched yeast and sodium selenite supplementation on postpartum depression and sexual satisfaction: A triple-blind controlled clinical trial
Authors: Rahimi Parnian , Shahnazi Mahnaz , Farshbaf-Khalili Azizeh , Ostarahimi Alireza , Mohammadi Marzieh 
Published: August 2023

Abstract
Background
Postpartum or postnatal depression is the most prevalent postpartum complication that considerably reduces sexual function in marital life, which may result in visible developmental delay, social and interactive problems in infants, and marital stress leading to divorce. The present study aimed to examine the effect of organic selenium (Saccharomyces cerevisiae yeast enriched with sodium selenite) and sodium selenite on postpartum depression and sexual satisfaction.
Methods
This clinical trial study was conducted on 108 women after childbirth. Participants were randomly assigned into two interventions (organic and inorganic selenium) and one placebo group with an allocation ratio of 1:1:1. Participants were given one identical 250mg oral capsule containing 200 micrograms of organic selenium or 200 micrograms of sodium selenite or placebo per day from October 2021 to July 2022 (admission time). The participants filled out Beck's depression inventory and sexual satisfaction questionnaire before and after the intervention. The mean score of postpartum depression and sexual satisfaction was measured before and after the study.
Results
All three groups were identical in terms of personal-social profiles. Depression score was significantly reduced in the intervention groups of organic selenium [adjusted mean difference=-2.77: (95% confidence interval:-0.97 to -4.57); P = 0.003] and organic selenium [adjusted mean difference=-1.77 (95% confidence interval: -0.00 to -3.53); P = 0.049] compared to control group by adjusting the baseline values. No significant difference was observed in the sexual satisfaction of intervention groups compared to the placebo at the end of intervention (P = 0.196).
Conclusion
Both organic and inorganic selenium could improve postpartum depression; however, the decline rate was greater by the yeast selenium. Sexual satisfaction had no significant change following supplementation.
Trial registration:
This study was registered in the Iranian Registry of Clinical Trials (IRCT20110606006709N23). URL: https://www.irct.ir/trial/56771.
Headaches During Pregnancy and the Risk of Subsequent Stroke
Authors: Nam Ki-Woong , Ha Sungyeon , Oh Min-Jeong , Oh Kyungmi , Kim Chi Kyung , Cho Geum Joon , Kim Young Seo , Bushnell Cheryl D 
Published: August 2023

Abstract
Background: Primary headache is a known risk factor for stroke in women and usually improves during the first trimester of pregnancy. However, despite this, some women develop headaches during pregnancy (G-HA), and the effect of this headache on subsequent stroke is unknown. In this study, we evaluated the association between G-HA and stroke after pregnancy in women.
Methods: Based on the Korean National Health Insurance Service database, we included women hospitalized for delivery between 2012 and 2013. G-HA was defined as a headache diagnosed during pregnancy. Primary outcome was any stroke that occurred during the observational periods from delivery to December 31, 2020. All diseases were identified based on data registered in the database using the International Classification of Disease-10th Revision-Clinical Modification codes.
Results: Of 906,187 pregnant women, G-HA was found in 56,813 (6.3%). During the observational periods, the G-HA (+) group had a significantly higher risk of any stroke [adjusted hazard ratio (aHR) = 1.59, 95% confidence interval (CI): 1.30-1.95], ischemic stroke (aHR = 1.50, 95% CI: 1.12-2.01), hemorrhagic stroke (aHR = 1.63, 95% CI: 1.23-2.15), and intracerebral hemorrhage (aHR = 1.63, 95% CI: 1.19-2.23) than the G-HA (-) group. When analyzed considering the interaction with history of headache, G-HA showed a significant association with hemorrhagic stroke, but lost its effect on ischemic stroke.
Conclusions: We demonstrated that G-HA was associated with subsequent stroke occurrence in pregnant women. However, the relationship between G-HA and ischemic stroke is mitigated by a history of pre-pregnancy headache.
Angiography-based Coronary Microvascular Assessment with and without Intracoronary Pressure Measurements ─ a Systematic Review
Authors: Kest Michael , Ágoston András , Szabó Gábor Tamás , Kiss Attila , Üveges Áron , Czuriga Dániel , Komócsi András , Hizoh István , Kőszegi Zsolt 
Published: August 2023

Abstract
Background:
In recent years, several indices have been proposed for quantifying coronary microvascular resistance.
Objective:
The objective of this study was to identify and analyze angiography-derived indices of microvascular resistance that have been validated against an invasive reference method. We aimed compare of these methods regarding their limits of agreement with their reference methods and exploring their advantages and inherent limitations.
Methods and results:
We searched PubMed from inception until 2022 for studies on different techniques for quantifying microvascular resistance. Seven studies met the inclusion criteria. Five studies included techniques that applied calculations based solely on invasive angiography (angiography-based methods), and were validated against invasively measured thermodilution-derived index of microvascular resistance (invasive IMR). The remaining two studies combined angiography with invasively measured intracoronary pressure data (combined angio- and pressure-based methods), and were validated against invasive Doppler Measurements. We converted the ± 1.96 standard deviation limits of agreement with the reference method from the seven studies into percentages relative to the cut-off value of the reference method. This conversion was performed to enhance the interpretability of the results. The lower limits of agreement for angiography-based methods ranged from − 122% to -60%, while the upper limits ranged from 74–135%. The range of the limits of agreement was considerably lower for the two combined angiography- and pressure-based methods, standing at -52–60% and − 25–27%.
Conclusion:
Our findings suggest that combined angiography- and pressure-based methods provide a more reliable assessment of microvascular resistance compared to methods relying solely on angiography.
Growth performance and carcass characteristics of broiler chicken fed on black soldier fly larvae meal: a product of fecal sludge waste management
Authors: Kirimi James G. , Riungu Joy N. , Kiogora Domenic , Marete Eunice N. , Kagendo Dorothy , Dey Prasanta , Oyoo Valary A. 
Published: August 2023

Abstract
Rearing black soldier fly is an efficient way to dispose of organic waste by converting them into protein-rich feed to substitute animal- and plant-based sources in animal feeds. The objective of this study was to determine the optimal inclusion level of black soldier fly larvae meal (BSFLM) as a substitute for soybean meal (SBM) in broiler diets and evaluate the impact on growth and carcass characteristics. Five isonitrogenous diets (D) (20% crude protein, CP) and isocaloric (3,200 Kcal/kg) were formulated such that BSFLM substituted SBM at 0% (control, D1), 25% (D2), 50% (D3), 75% (D4), and 100% (D5) on a protein basis. A total of 270 broilers (Cobb 500) were randomly assigned to the five treatments in triplicate per diet. BSFLM displayed higher fat content (44.84 ± 0.08%). Average daily feed intake (ADFI) decreased with an increase in BSFLM in the diets (p = 0.004). However, overall weight (OW) was high (1,296.97 ± 46.19 g) on 100% substitution of SBM with BSFLM (D5). Breast fat content averaged 6.06 ± 0.97 g for D1 and 15.30 ± 0.5 g for D5. This study has demonstrated that BSFLM can partially or wholly replace conventional SBM in the diet of broiler chicken.
COVID-19 pandemic, welfare programs, and access to ‘free water’ in Ghana: how did the urban poor fare?
Authors: Achore Meshack , Bisung Elijah , Kuuire Vincent 
Published: August 2023

Abstract

Frequent hand washing has been recommended by public health officials as one of the key preventive measures to reduce the transmission of COVID-19. Yet globally, 844 million people live without access to a safe drinking water source. This study explores the impact of the COVID-19 pandemic, its associated public health response measures and government social support on water access in informal settlements in Ghana using qualitative studies. Thirty (30) participants were interviewed in Accra and Tamale. Data were transcribed and inductively analyzed using NVivo. Overall, participants indicate that COVID-19 exacerbated their water insecurity issues in many ways including (1) limiting water source visits for fear of contracting the virus; (2) through public health restrictions that affected their ability to access water outside their households; and (3) increased cost of vended water. Most participants also highlighted that they did not benefit from the ‘6 months of free water initiative’ by the government of Ghana. As countries formulate plans to rebuild their economies, the inequalities underscored by the COVID-19 pandemic should offer renewed attention to the significance of safe water access for all, particularly concerning public and population health.