bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Possibility of Using Barley Grains Extract as an Acidic Corrosion Inhibitor for Carbon Steel
Authors: Alhaidar Bashar , Reeshah Fidaa , Jammoal Yousef 
Published: September 2023

تمت دراسة تأثير مستخلصات بذور الشعير على تآكل الفولاذ الكربوني في 1M حمض كلور الماء للتحقق من إمكانية استخدام كمثبط أخضر في عملية التنظيف وإزالة الترسبات الحمضية للمبادلات الحرارية، عند درجات حرارة مختلفة. أُجريت عمليات الاستخلاص باستخدام الايثانول والماء %50 حجماً، وبطريقتي النقع والأمواج فوق الصوتية. تمت دراسة آلية تأثير المثبط الذي أعطى أفضل كفاءة تثبيط، من خلال دراسة الامتزاز والتآكل بالطرق الكهروكيميائية (مخططات تافل، ومطيافية المقاومة الكهروكيميائية) والحسابات الترمودينامكية. أظهرت نتائج الدراسة عدم وجود تأثير لطريقة الاستخراج على سلوك التثبيط ، حيث أظهر التثبيط كدالة للتركيز زيادة معنوية في كفاءة التثبيط حتى التركيز 400 جزء في المليون ، ثم ظهرت مستقلة عنها في كلتا الطريقتين. ، ومع ذلك كانت درجة الحماية أعلى لمستخلص طريقة النقع عند التركيز 800ppm 87.01%) مقارنة بـ 80.56% لمستخلص الأمواج فوق الصوتية). أشارت دراسة آلية التثبيط لهذا المستخلص إلى إمكانية الامتزاز الكيميائي للمستخلص وإعادة لترتيب الشحنات في الطبقة المزدوجة الكهربائية . أبدت فعالية التثبيط ارتفاعاً مع درجة الحرارة.
Microscopic evaluation of orbital moment in ferromagnetic resonance
Authors: Ishii Yuta , Yamasaki Yuichi , Kozuka Yusuke , Lustikova Jana , Nii Yoichi , Onose Yoshinori , Yokoyama Yuichi , Mizumaki Masaichiro , Adachi Jun-ichi , Nakao Hironori , Arima Taka-hisa , Wakabayashi Yusuke 
Published: September 2023

Abstract
Time-resolved X-ray magnetic circular dichroism under the effects of ferromagnetic resonance (FMR), known as X-ray ferromagnetic resonance (XFMR) measurements, enables direct detection of precession dynamics of magnetic moment. Here we demonstrated XFMR measurements and Bayesian analyses as a quantitative probe for the precession of spin and orbital magnetic moments under the FMR effect. Magnetization precessions in two different Pt/Ni-Fe thin film samples were directly detected. Bayesian analyses of the XFMR energy spectra around the Ni L2,3 absorption edges reveal the different direction of the precession axis of spin and orbital moments. This different dynamical behaviors of spin and orbital moments can be attributed to the perpendicular magnetic anisotropy on the orbital moment in Pt/Ni-Fe thin films. Our study paves the way for a microscopic investigation of the contribution of the orbital magnetic moment to magnetization dynamics.
Bioinformatics analysis of ceRNA network of autophagy-related genes in childhood asthma
Authors: Zhu Hao , Shi Jiao , Liao Qing , Xu Biao 
Published: September 2023

Abstract
Background
The key differentially expressed autophagy-related genes(DE-ARGs) in childhood asthma were screened, and lncRNA-miRNA-mRNA networks were constructed to further understand the pathogenesis of asthma.
Methods
DE-ARGs were identified using the Gene Expression Database (GEO) and the Human Autophagy Database. These DE-ARGs were subjected to Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, Gene Set Enrichment Analysis, and protein-protein interaction network analysis followed by further verification of core gene expression. MiRNAs were inversely predicted using two databases (miRDB and ENCORI), while miRNA-lncRNA interactions were predicted using LncBase and ENCORI databases. After excluding lncRNAs present only in the nucleus and extracellular space, a competitive endogenous RNA (ceRNA) network was established and further analyzed. Finally, we validated mRNA expression levels in the ceRNA network by quantitative real-time PCR (qRT-PCR).
Results
31 DE-ARGs were obtained, of which 29 were up-regulated and two were down-regulated. Autophagy, regulation of apoptotic signaling pathways, interferon-α/β signaling, interferon γ signaling, autophagy-animal, and apoptosis pathways were mainly enriched in asthma. Five hub genes (VEGFA, CFLAR, RELA, FAS, and ATF6) were further analyzed to verify the expression and diagnostic efficacy of these core genes using the GEO dataset. Finally, four hub genes (VEGFA, CFLAR, RELA, and FAS) were obtained. Through the combination of literature search, ceRNA network mechanism, and predicted miRNAs and lncRNAs analysis, a ceRNA network of four mRNAs (VEGFA, CFLAR, RELA, and FAS), three miRNAs (hsa-miR-320b, hsa-miR-22-3p, and hsa-miR-625-5p), and 35 lncRNAs was finally constructed. qRT-PCR showed that FAS was signifcantly upregulated.
Conclusion
Four DE-ARGs, especially FAS, may play a key role in asthma. The new ceRNA network may help to explore the mechanism of autophagy in asthma, which may be important for the development of new treatment options.
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants
Authors: Merk Timon , Köhler Richard , Peterson Victoria , Lyra Laura , Vanhoecke Jonathan , Chikermane Meera , Binns Thomas , Li Ningfei , Walton Ashley , Bush Alan , Sisterson Nathan , Busch Johannes , Lofredi Roxanne , Habets Jeroen , Huebl Julius , Zhu Guanyu , Yin Zixiao , Zhao Baotian , Merkl Angela , Bajbouj Malek , Krause Patricia , Faust Katharina , Schneider Gerd-Helge , Horn Andreas , Zhang Jianguo , Kühn Andrea , Richardson R. Mark , Neumann Wolf-Julian 
Published: September 2023

Abstract
Brain computer interfaces (BCI) provide unprecedented spatiotemporal precision that will enable significant expansion in how numerous brain disorders are treated. Decoding dynamic patient states from brain signals with machine learning is required to leverage this precision, but a standardized framework for identifying and advancing novel clinical BCI approaches does not exist. Here, we developed a platform that integrates brain signal decoding with connectomics and demonstrate its utility across 123 hours of invasively recorded brain data from 73 neurosurgical patients treated for movement disorders, depression and epilepsy. First, we introduce connectomics-informed movement decoders that generalize across cohorts with Parkinson’s disease and epilepsy from the US, Europe and China. Next, we reveal network targets for emotion decoding in left prefrontal and cingulate circuits in DBS patients with major depression. Finally, we showcase opportunities to improve seizure detection in responsive neurostimulation for epilepsy. Our platform provides rapid, high-accuracy decoding for precision medicine approaches that can dynamically adapt neuromodulation therapies in response to the individual needs of patients.
LiLA: Lipid Lung-based ATLAS built Through a Comprehensive Workflow Designed for an Accurate Lipid Annotation
Authors: Gonzalez-Riano Carolina , Requena Belén Fernández , Nadeem Sajid , Reddy Vineel , Naidoo Vanessa , Glasgow Joel , Steyn Adrie , Barbas Coral 
Published: September 2023

Abstract
Accurate lipid annotation is crucial for understanding the role of lipids in health and disease and identifying therapeutic targets. However, annotating the wide variety of lipid species in biological samples remains challenging in untargeted lipidomic studies. In this work, we present an optimized lipid annotation workflow based on the combination of LC-MS and MS/MS strategies, four bioinformatic tools, and a decision-tree-based approach to support the accurate annotation and semi-quantification of the lipid species present in lung tissue from control mice. The developed workflow allowed us to generate a lipid lung-based ATLAS (LiLA), which was then employed to unveil the lipidomic signatures of the Mycobacterium tuberculosis (Mtb) infection at two different time points for a deeper understanding of the disease progression. This workflow, combined with manual inspection strategies of MS/MS data, can enhance the annotation process for lipidomic studies and guide the generation of sample-specific lipidome maps. LiLA serves as a freely available data resource that can be employed in future studies to address lipidomic alterations in mice lung tissue.
Genital Mycoplasma and genital disorders among women of childbearing age in Franceville, South-Est Gabon.
Authors: Moghoa Kelly Hornelia Mbombe , Onanga Richard , Bignioumba Michelle , Nzambe Jean Ulrich Muandze , Lendamba Romeo Wenceslas , Mouanga-Ndzime Yann , Mahmoudou Saidou , Mba Romuald Be , Pecmann Klara , Gafou Amahani , Kassa Roland Fabrice Kassa , Bisseye Cyrille 
Published: September 2023

Abstract
Objective. This study evaluated the prevalence of Ureaplasma spp. and Mycoplasma hominis and their association with genital disorders (bacterial vaginosis, aerobic vaginitis, and vulvovaginal candidiasis).
Methods. The IST2 kit identified genital mycoplasmas. Nugent score and microscopic observation of neutrophils and bacteria served to diagnose bacterial vaginosis and aerobic vaginitis. Chi-square or Fisher’s exact test served for statistical analysis.
Results. The prevalence of M. hominis and Ureaplasma spp. was estimated at 2% and 41%, respectively, and Ureaplasma spp./M. hominis was 32%. The prevalence of BV, VVC, and AV was de 68%, 35%, and 54%, respectively. Group B Streptococcus (P=0.006, OR=0.41, 95% CI=0.22–0.77) (P=0.002, OR=0.30, 95% CI=0.14–0.63) was not associated with M. hominis, Ureaplasma spp./M. hominis respectively.
Conclusion. This study reports a high prevalence of genital mycoplasmas. VVC, AV, and BV were frequently encountered, but the association with genital mycoplasmas was not statistically significant.
Cross-cultural adaptation and validation of the COPD Patient- Reported Experience Measure (PREM-C9) in Spanish and Catalan.
Authors: Moharra Montserrat , Llupià Anna , Bayés Beatriu , Escarrabill Joan , Cari Almazán 
Published: September 2023

Abstract
Patient Reported Experience Measures (PREMS) are questionnaires developed to assess the patient experience(1) and incorporate a vision of patient centered care as a new element of value in the quality of healthcare. The PREM-C9 was developed and tested recently in the UK for patients with chronic obstructive pulmonary disease (CODP). The aim of the current study was to test the validity and reliability of the PREM-C9 in Spanish and Catalan. 289 patients with COPD completed the PREM-C9 (male 71.3%; female 28.7%). Internal consistency was high for both the Spanish [Cronbach’s alpha = 0.812] and Catalan [Cronbach’s alpha = 0.877] versions. Confirmatory Factor Analysis (CFA) proved the item distribution and dimensional structure of the questionnaire except for item2 of the scale “My everyday life with COPD”. Goodness-of-fit indices were very close to acceptable values for the CFI/TLI of 0.90. The three hypotheses tested to assess known groups’ validity were all confirmed. Participants with lower levels of education or with higher levels of breathlessness had poorer scores on the PREM-C9, while respondents reporting higher overall satisfaction with care reported better scores on the questionnaire. Accessibility to healthcare services and breathlessness were important factors in the regression model used to investigate variables affecting PREM-C9 scores accounting for 20% of the variance. This study has provided evidence for good reliability and structural and construct validity of the Catalan and Spanish versions of the PREM-C9.
Performance evaluation of Abbott real-time PCR in the diagnosis of Mycobacterium tuberculosis in Addis Ababa, Ethiopia: A cross-sectional descriptive study
Authors: Tesema Million Hailu , Berta Kibebu Kinfu , Bitew Adane , Zealiyas Kidist , Bogale Agajie Likie , Yenew Bazezew , Deriba Getu , Gessew Gebreab Teklebirhan , Adane Sisay , Yizengaw Ajanew , Tesfaye Ephrem , Getaneh Yimam , Olu Olushayo Oluseun , Kebede Abebaw 
Published: September 2023

Abstract
Background
In 2018, an estimated 10 million people developed tuberculosis, of whom more than 1.45 million died. The microscopy method used in most tuberculosis high burden and resource-limited countries is less accurate for diagnosing the disease. Thus, evaluation of the available diagnostic modalities in the country is crucial, and this study aimed to evaluate the performance of Abbott real-time PCR as a diagnostic technique for tuberculosis in Ethiopia.
Methods
A cross-sectional survey was conducted using sputum specimens collected from 150 presumptive tuberculosis patients from both public and private health facilities in Addis Ababa, Ethiopia, from May to June 2019. The laboratory investigation was conducted at the National Reference Laboratories of the Ethiopian Public Health Institute (EPHI).
Results
This finding indicated that 84.7% (127/150) and 61.3% (92/150) were smear and culture-negative, respectively. The overall diagnostic sensitivity of the Abbott real-time polymerase chain reaction (PCR) technique for the diagnosis of tuberculosis was 89.7% (52/58), that for smear-negative was 80.6% (29/36), and that for specificity was 92.4% (85/92). Drug resistance testing demonstrated diagnostic specificities of 87.5% and 100% for isoniazid and rifampicin, respectively, and a sensitivity of 92.3% for both.
Conclusions
This study demonstrated an outstanding performance of the Abbott real-time PCR technique for diagnosing tuberculosis using sputum specimens using culture as a reference standard. Thus, we recommend that Ethiopia's ministry and tuberculosis program implementers consider the Abbott real-time PCR technique for diagnosing tuberculosis and drug resistance testing, which is likely to be included in the national guidelines.
The Impact of Repeated Preheating of Matrix Modifying Bulk Fill Resin Composite on Post-gel Polymerization Shrinkage Strain (in Vitro Study)
Authors: fathy Heba , Gamal Wael , Riad Mona 
Published: September 2023

Abstract
Background: This study evaluated the effect of repeated preheating cycles of matrix-modifying bulk fill resin composites on the postgel polymerization shrinkage strain.
Methods: Forty resin composite specimens were prepared using a Teflon mold (7 mm length x 4 mm width x 2 mm height). Each specimen was linked to a strain gauge and strain monitoring equipment (Strain-Meter PCD-300A Kyowa-Electronic Instruments Co, LTD, Tokyo, Japan) for measuring the postgel polymerizationshrinkage strain (um/m) of the resin composite. Preheating of the resin composite syringe was accomplished using Active Resin Heat (temperature of 68°C). According to the number of preheating cycles of the resin composite syringes, the specimens were divided into four equal groups: P0 (control), resin composite packed and cured at room temperature [23 ± 1°C], P1: preheated once, P2: preheated twice and P3: preheated three times prior to packing and curing for 30 seconds according to the manufacturer’s instructions. Statistical analysis was performed using Shapiro‒Wilk test for normality. ANOVA single factor was used as the test of significance followed by Tukey Hsd/Kramer with the level of significance set at 0.05.
Results: Data analysis revealed insignificant differences in the postgel polymerization shrinkage strain among all tested groups (p≥0.05).
Conclusions: The repeated preheating cycles of matrix-modifying bulk-fill resin composites prior to curing had no adverse effect on the induced postgel polymerization shrinkage strain.
Clinical Relevance: The results of this study confirmed that clinicians can consider repeatedly preheating resin composites in dental practices. The information of comparable performance regarding postgel polymerization shrinkage when applying preheated composites as room temperature cured resin composites could be of utmost significance as the same resin composite syringe can clinically undergo numerous preheating cycles before it is completely consumed with the advantage of a transient reduction in viscosity, improving restoration adaptability to the cavity. Its use in routine care can be considered a good practice.
Medium-term results of laparoscopic lateral duodenojejunostomy for pediatric superior mesenteric artery compression syndrome
Authors: Tang Jingfeng , Zhang Mengxin , Zhou Ying , Cao Guoqing , Li Shuai , Zhang Xi , Tang Shaotao 
Published: September 2023

Abstract
Purpose: Laparoscopic lateral duodenojejunostomy (LLD) has been shown to be feasible in some reported cases for pediatric Wilkie’s syndrome, also known as superior mesenteric artery compression syndrome (SMAS), but its medium-term outcomes are lacking. We summarized the experience of LLD for SMAS in children, aiming to confirm its effectiveness.
Methods: From January 2013 to May 2021, SMAS children who received LLDwere included in this retrospective study. The procedure was carried out utilizing the four-trocar technique. The elevation of the transverse colon allows good exposure of the dilated and bulging second and third sections of the duodenum. Using a linear stapler, we established a lateral anastomosis connecting the proximal jejunum with the third part of duodenum. Following that, a running suture was used to intracorporeally close the common enterotomy. Clinical data on patients was collected for analysis.
Results: We retrospectively analyzed 9 SMAS patients (6 females and 3 males) who underwent LLD, aged between 7 and 17 years old. The mean operative time was 118.4±16.5 min and mean estimated blood loss was 5.6±1.4 ml. There was no conversion, intraoperative complications or immediate postoperative complications. The mean postoperative hospital stay was 6.8 days. During follow-up (20 months), seven patients experienced complete recovery of symptoms prior to surgery. One patient still had mild vomiting, which resolved with medication. Another patient developed psychological nausea, which significantly improved after treatment with education and diet management.
Conclusions: LLD represents a feasible and effective treatment option for SMAS in well-selected children, providing favorable medium-term outcomes.
The Efficacy and Safety of Perioperative Therapy for Resectable Locally Gastric Cancer: A Network Meta-Analysis of Randomized Clinical Trials
Authors: Kuang Ziyu , Sun Qianhui , Cao Luchang , Ma Xinyi , Wang Jiaxi , Liu Kexin , Li Jie 
Published: September 2023

Abstract
Objective
This study aimed to determine the optimal perioperative treatment regimen for locally resectable gastric cancer (GC).
Methods
A comprehensive literature search was conducted focusing on phase II/III randomized controlled trials (RCTs) assessing perioperative chemotherapy and chemoradiotherapy in locally resectable GC. The R0 resection rate, overall survival (OS), disease-free survival (DFS), and incidence of grade 3 or higher non-surgical adverse events (SAEs) associated with various perioperative regimens were analyzed. Bayesian network meta-analysis (NMA) was performed to compare the treatment regimens and rank their efficacy.
Results
A total of 30 RCTs involving 8346 patients were included in this study. Neoadjuvant XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared to surgery alone, and the former had the highest probability of being the most effective option in this context. Neoadjuvant plus adjuvant FLOT was associated with the highest probability of being the best regimen for OS. Due to limited data, no definitive ranking could be determined for DFS. Considering non-surgical SAEs, FLO emerged as the safest regimen.
Conclusions
This study provides valuable insights for clinicians in selecting perioperative treatment regimens for locally resectable GC. However, further studies are needed to validate these findings.
Impact of Atrial Septal Defect Closure on Mortality in Older Patients
Authors: Khamplod Sipawath , Kaolawanich Yodying , Karaketklang Khemajira , Ratanasit Nithima 
Published: September 2023

Abstract
Background: Atrial septal defect (ASD) is a common form of adult congenital heart disease that can lead to long-term adverse outcomes if left untreated. Early closure of ASD has been associated with excellent outcomes and lower complication rates. However, there is limited evidence regarding the prognosis of ASD closure in older adults. This study aims to evaluate the mortality rates in older ASD patients with and without closure.
Methods: A retrospective cohort study was conducted on patients aged over 40 years with ASD between 2001 and 2017. Patients were followed up to assess all-cause mortality. Univariable and multivariable analyses were performed to identify the predictors of mortality. A p-value of <0.05 was considered statistically significant.
Results: The cohort consisted of 450 patients (mean age 56.6±10.4 years, 77.3% female), with 66% aged between 40 and 60 years, and 34% over 60 years. Within the cohort, 299 underwent ASD closure (201 with transcatheter and 98 with surgical closure). During the median follow-up duration of 7.9 years, 51 patients died. The unadjusted cumulative 10-year rate of mortality was 3% in patients with ASD closure, and 34% in patients without ASD closure (log-rank p<0.001). Multivariable analysis revealed that age (hazard ratio [HR] 1.03, 95% confident interval [CI] 1.007-1.06, p=0.001), NYHA class (HR 2.58, 95% CI 1.61-4.12, p<0.001), blood urea nitrogen (BUN) (HR 1.08, 95% CI 1.03-1.10, p<0.001), right ventricular systolic pressure (RVSP) (HR 1.02, 95% CI 1.007-1.04, p=0.004), and ASD closure (HR 0.07, 95% CI 0.03-0.17, p<0.001) were independently associated with mortality.
Conclusion: ASD closure demonstrated favorable outcomes in older patients. Age, NYHA class, BUN, RVSP, and ASD closure were identified as independent factors linked to mortality in this population.
Primary nonadherence to oral cancer chemotherapy in hepatocellular carcinoma: Prevalence and predictive factors in Vietnam
Authors: Ky Thai Doan , Loan Nguyen Thi , Thinh Nguyen Tien , Binh Mai Thanh 
Published: September 2023

Abstract

Purpose
Standard oral cancer chemotherapy (OCT) or targeted therapy (OTT) has expanded the treatment methods for hepatocellular carcinoma (HCC). However, its primary nonadherence causes a reduction in efficacy. We aimed to evaluate the status of nonadherence and influencing factors among outpatient patients with HCC.
Patients and methods:
In 2021, 384 Vietnamese HCC patients were included. Nonadherence to OCT was determined using the eight-item Morisky Medication Adherence Scale. Five factors—condition-related, patient-related, socioeconomic-related, treatment-related, and healthcare-system/provider-related—were measured in a correlated manner with noncompliant treatment.
Results
A total of 54,8% of HCC outpatients were nonadherent to OCT, with a mean Morisky score of 5.19. They dropped out of the treatment mainly because of drug side effects, such as fatigue (72.4%), hand-foot syndrome (42.7%), diarrhea (38.3%), nausea (25%), insomnia (24.7%), abdominal pain (12%), and anxiety about these adverse events (65.9%) (P < 0.05). Additionally, financial difficulties and low relative copayments were significantly correlated with the noncompliant treatment of patients (OR = 2.29, 95% CI = 1.32–3.98, P = 0.003; OR = 4.36, 95% CI = 0.95–19.93, P = 0.039, respectively). Moreover, inadequate individual information about the clinical course, the art of treatment, and medication usage instructions were suggestive barriers to adherence to treatment (OR = 1.96, 95% CI = 1.08–3.55, P = 0.024; OR = 1.86, 95% CI = 1.1–3.14, P = 0.02; OR = 2.34, 95% CI = 1.29–4.26, P = 0.004, respectively). Finally, a low level of trust in doctors was an important factor in nonadherence (P = 0.00001).
Conclusions
This study suggests a high rate of primary nonadherence to standard oral targeted therapy among HCC outpatient patients because of drug side effects, patient awareness of treatment, and lack of confidence in healthcare providers. Close supervision, proper medication instructions, appropriate dosage reductions, and comprehensive patient counseling might be necessary to control nonadherence.