bluuebunny/crossref_metadata_2025_split huggingface dataset:
Begründung und Geltung. Rhetorische Verflechtungen von Recht und Literatur
Authors: Arnold Stefan , Wagner-Egelhaaf Martina 
Published: July 2023

ZusammenfassungRecht und Literatur bzw. Rechts- und Literaturwissenschaft sind über die Rhetorik historisch und systematisch miteinander verbunden. Allerdings hat die Rhetorik in beiden Disziplinen einen unterschiedlichen Stellenwert: Während die Rhetorik in der Literaturwissenschaft ein prominentes Instrumentarium der Textanalyse darstellt, dabei aber oft auf die Figurenlehre reduziert wird, ist ihr Ansehen in der Rechtswissenschaft eher gering, insofern Rhetorik als etwas der juristischen ,Wahrheit‘ Hinzugefügtes begriffen wird. Der Beitrag argumentiert dafür, dass jede Redeäußerung grundsätzlich eine rhetorische Dimension hat und verweist auf die produktive Vielgestaltigkeit der Rhetorik. Insbesondere nimmt er Geltungsbegründungen in Rechts- und Literaturwissenschaft in den Blick, indem er auf der einen Seite zeigt, wie in der Poetik des 18. Jahrhunderts Geltung rhetorisch erzeugt wird, und auf der anderen Seite die rhetorische Verfasstheit von Gerichtsurteilen als Untersuchungsbereich vorstellt. Außerdem wird eine Matrix zur differenzierten Erfassung des Geltungsbegriffs vorgestellt.
Integration of nuclear Ca2+ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression
Authors: Karpova Anna , Samer Sebastian , Turacak Rabia , Yuanxiang PingAn , Kreutz Michael R. 
Published: July 2023

AbstractNuclear Ca2+ waves elicited by NMDAR and L-type voltage-gated Ca2+-channels as well as protein transport from synapse-to-nucleus are both instrumental in control of plasticity-related gene expression. At present it is not known whether fast [Ca2+]n transients converge in the nucleus with signaling of synapto-nuclear protein messenger. Jacob is a protein that translocate a signalosome from N-methyl-D-aspartate receptors (NMDAR) to the nucleus and that docks this signalosome to the transcription factor CREB. Here we show that the residing time of Jacob in the nucleoplasm strictly correlates with nuclear [Ca2+]n transients elicited by neuronal activity. A steep increase in [Ca2+]n induces instantaneous uncoupling of Jacob from LaminB1 at the nuclear lamina and promotes the association with the transcription factor cAMP-responsive element-binding protein (CREB) in hippocampal neurons. The size of the Jacob pool at the nuclear lamina is controlled by previous activity-dependent nuclear import, and thereby captures the previous history of NMDAR-induced nucleocytoplasmic shuttling. Moreover, the localization of Jacob at the nuclear lamina strongly correlates with synaptic activity and [Ca2+]n waves reflecting ongoing neuronal activity. In consequence, the resulting extension of the nuclear residing time of Jacob amplifies the capacity of the Jacob signalosome to regulate CREB-dependent gene expression and will, thereby, compensate for the relatively small number of molecules reaching the nucleus from individual synapses.
Sigmoid neovagina prolapse treated with Altemeier procedure: case report and systematic review of the literature
Authors: Drusany Starič Kristina , Distefano Rosario Emanuele Carlo , Norčič Gregor 
Published: July 2023

Abstract

Background
Bowel vaginoplasty is a surgical method for neovagina construction that, despite its advantages over other techniques, is still burdened by complications such as prolapse. The incidence of sigmoid neovagina prolapse (SNP) is difficult to determine, and there are no evidence-based recommendations for treatment. We present a case of SNP and a systematic review of previous cases.

Case
A 73-year-old woman presented with stage III prolapse of her sigmoid neovagina constructed 51 years prior. Dynamic pelvic MRI revealed that the majority of the prolapse was due to the mucosa’s loss of support. Due to the presence of numerous pelvic adhesions, an alternative to the laparoscopic approach was evaluated by a multidisciplinary team which led to the patient being treated using a modification of Altemeier’s procedure.

Systematic review
After PROSPERO Registration (CRD42023400677), a systematic search of Medline and Scopus was performed using specific search terms. Study metadata including patient demographics, prolapse measurements, reconstruction techniques, recurrence rates, and timing were extracted. Fourteen studies comprising 17 cases of SNP were included. Vaginal resection of the redundant sigmoid, comprising Altemeier’s procedure, was the most definitive surgery, but it was also associated with recurrences in three cases. Laparoscopic sacropexy was the second most definitive surgery with no recurrence reported.

Conclusion
Our review shows that the recurrence after correction of sigmoid neovagina prolapses is higher than previously reported. Laparoscopy colposacropexy appeared to be the best approach, but it’s not always feasible. In these scenarios, a mucosal resection using the Altemeier’s procedure is the most effective surgery.
Boosting enzymatic hydrolysis of steam-pretreated softwood by laccase and endo-β-mannanase enzymes from Streptomyces ipomoeae CECT 3341
Authors: Eugenio María E. , Domínguez Gabriela , Molina-Guijarro José M. , Hernández Manuel , Arias María E. , Ibarra David 
Published: July 2023

AbstractLigninases and hemicellulases are crucial as accessory enzymes to increase the enzymatic hydrolysis of lignocellulose, boosting sugars production from which biofuels and bioproducts could be obtained. In order to find new sources of these accessory enzymes, this study evaluates the potential of laccase and mannanase enzymes from Streptomyces ipomoeae for improving the conventional hydrolysis with commercial cellulases of steam-pretreated softwood. For that, different laccase treatment and mannanase supplementation strategies were performed. S. ipomoeae laccase increased both glucose and xylose production (17.8% and 9.3%, respectively), which was attributed to a removal of phenols of 29%. Moreover, the combination of laccase and alkaline extraction produced a lignin reduction of 16.2%, improving the glucose and xylose production by almost 41.3% and 44.9%, respectively. On the other hand, the supplementation of S. ipomoeae mannanase to the hydrolysis 24 h before the addition of cellulases increased the glucose (18.4%), xylose (12.3%), and mannose (47.2%) production.
Breaking the Barrier: A Study on Multi‐drug Resistance in Breast Abscess at an Academic Malaysian Hospital
Authors: Lee Choon Jiat , Lai Lee Lee , See Mee Hoong , Velayuthan Rukumani Devi , Doon Yoke Kiet , Lim Phaik Eem , Lim Crystale Siew Ying , Poong Sze Wan , Chong Christina Shook Cheng , Lee Pui Yuei , Tan Yong Hui 
Published: July 2023

AbstractBackgroundIn recent years, the increase in antibiotics usage locally has led to a worrying emergence of multi‐drug resistant organisms (MDRO), with the Malaysian prevalence rate of methicillin‐resistant Staphylococcus aureus (MRSA) ranging from 17.2 to 28.1% between 1999 and 2017. A study has shown that 7% of all non‐lactational breast abscesses are caused by MRSA. Although aspiration offers less morbidities compared to surgical drainage, about 20% of women infected by MRSA who initially underwent aspiration subsequently require surgical drainage. This study is conducted to determine the link between aetiology, antimicrobial resistance pattern and treatment modalities of breast abscesses.MethodsRetrospective study of reviewing microbiology specimens of breast abscess patients treated at Universiti Malaya Medical Centre from 2015 to 2020. Data collected from microbiology database and electronic medical records were analysed using SPSS V21.ResultA total of 210 specimens from 153 patients were analysed. One‐fifth (19.5%) of the specimens isolated were MDRO. Lactational associated infections had the largest proportion of MDR in comparison to non‐lactational and secondary infections (38.5%, 21.7%, 25.7%, respectively; p = 0.23). Staphylococcus epidermidis recorded the highest number of MDR (n = 12) followed by S. aureus (n = 8). Adjusted by aetiological groups, the presence of MDRO is linked to failure of single aspirations (p = 0.554) and significantly doubled the risk of undergoing surgical drainage for resolution (p = 0.041).ConclusionMDR in breast abscess should be recognised as an increasing healthcare burden due to a paradigm shift of MDRO and a rise of resistance cases among lactational associated infection that were vulnerable to undergo surgical incision and drainage for resolution.
Effects of sarcopenia and myosteatosis are alleviated in reduced port surgery for diverticulitis
Authors: Schaffler-Schaden Dagmar , Mittermair Christof , Bittner Ferdinand , Zintl Ramona , Schaffler Gottfried , Weiss Helmut 
Published: July 2023

Abstract
Purpose
Many studies report the predictive value of sarcopenia, myosteatosis, and visceral fat for clinical outcome after surgery. Radiological analysis of body composition is a valuable tool for identifying high-risk patients undergoing major abdominal surgery. Despite the high prevalence of diverticular disease, patients with benign conditions have hardly been studied in this context. This study aims to evaluate the impact of reduced port surgery on the outcome of patients with diverticulitis, adjusting for body composition.

Methods
We assessed body composition profiles using preoperative CT slices at the level of the third lumbar vertebra in consecutive patients undergoing single-port elective surgery for diverticulitis in a single center. The effects of sarcopenia, myosteatosis, and visceral fat on mortality and complications were analyzed and adjusted for age and gender.

Results
We enrolled 99 patients with diverticulitis undergoing elective single port surgery in this study. Of the patients, 71.2% had sarcopenia and 60.6% had myosteatosis. The overall complication rate was 17.2%, and the rate of anastomotic leakage was 4.0%. Thirty-day mortality was 2.0%. Loss of skeletal muscle mass, myosteatosis, and visceral fat were not associated with higher complication or mortality rates in our cohort.

Conclusion
Body composition profiles had no impact on the clinical course in our cohort. Minimally invasive surgery may potentially compensate for the adverse effects of sarcopenia and myosteatosis in diverticulitis.
FIT for purpose: study protocol for a randomized controlled trial to personalize surveillance colonoscopy for individuals at elevated risk of colorectal cancer
Authors: Winter Jean M. , Cornthwaite Kathryn J. , Young Graeme P. , Wilson Carlene , Chen Gang , Woodman Richard , Coats Michelle , Fraser Robert , Cock Charles , Bampton Peter , Symonds Erin L. 
Published: July 2023

Abstract
Purpose
There is increasing demand for colorectal cancer (CRC) surveillance, but healthcare capacity is limited. The burden on colonoscopy resources could be reduced by personalizing surveillance frequency using the fecal immunochemical test (FIT). This study will determine the safety, cost-effectiveness, and patient acceptance of using FIT to extend surveillance colonoscopy intervals for individuals at elevated risk of CRC.

Methods
This multicenter, prospective, randomized controlled trial will invite participants who are scheduled for surveillance colonoscopy (due to a personal history of adenomas or a family history of CRC) and who have returned a low fecal hemoglobin (< 2 μg Hb/g feces; F-Hb) using a two-sample FIT (OC Sensor, Eiken Chemical Company) in the prior 3 years. A total of 1344 individuals will be randomized to either surveillance colonoscopy as scheduled or delayed by 1 or 2 years for individuals originally recommended a 3- or 5-year surveillance interval, respectively. The primary endpoint is incidence of advanced neoplasia (advanced adenoma and/or CRC). Secondary endpoints include cost-effectiveness and consumer acceptability of extending surveillance intervals, determined using surveys and discrete choice experiments.

Conclusion
This study will establish the safety, cost-effectiveness, and acceptability of utilizing a low FIT Hb result to extend colonoscopy surveillance intervals in a cohort at elevated risk for CRC. This personalized approach to CRC surveillance will lead to a reduction in unnecessary colonoscopies, increases in healthcare savings, and a better patient experience.

Trial registration
Registration was approved on December 9, 2019 with the Australian New Zealand Clinical Trials Registry ANZCTR 12619001743156.
Thyroid disturbances after COVID-19 and the effect of vaccination in children: a prospective tri-center registry analysis
Authors: Herczeg Vivien , Garai Réka , Takács Johanna , Kovács Fanni , Luczay Andrea , Hrapka Erzsébet , Krivácsy Péter , Hosszú Éva , Beniczky Nikolett Jusztina , Németh Ágnes , Szilágyi Eszter Szabina , Pécsi Anna , Szabó Zsófia , Szabó Attila József , Tóth-Heyn Péter 
Published: July 2023

AbstractRapidly evolving clinical data suggest that the novel coronavirus (SARS-CoV-2) and vaccination against COVID-19 might be associated with thyroid disturbances. However, studies remain limited among the pediatric population. Our aim was to assess the prevalence and permanence of thyroid autoimmunity (TA) and dysfunction in children after an acute infection and its potential association with vaccination. A prospective, multicenter registry analysis was performed among 458 children (mean age: 12.4 ± 3,8 years, 45.4% male) with preceding COVID-19. Patient inclusion lasted from 24th March, 2021 to 23rd March, 2022 at three pediatric outpatient facilities at Semmelweis University, Budapest. Primary outcomes were the rate of thyroid disturbances assessed by laboratory parameters (thyroid function tests, antithyroglobulin [ATG] and anti-thyroid peroxidase [ATPO] antibodies) and thyroid ultrasound. TA rate among vaccinated and unvaccinated children was determined. Children with newly diagnosed thyroid alterations were followed up for 12.7 ± 4.3 months. Six children had previous thyroid disease. Out of 452 children, 30 cases (6.6%) of newly diagnosed TA (six of them had abnormal thyroid-stimulating hormone [TSH] levels) and eight cases (1.8%) of isolated TSH elevation were observed. Ultrasound-proven autoimmune thyroiditis (AIT) was 4.0%. No association was found between COVID-19 vaccination and thyroid autoimmunity (χ2(1,N = 452) = 0.138, p = 0.815). Among children with TA, 73.3% had long-lasting alterations. Conclusion: Vaccination had no effect on the prevalence of TA. Until further controlled studies state otherwise, children with preceding COVID-19 might benefit from thyroid screening.

What is Known:• Numerous case reports implicate that coronavirus disease-2019 (COVID-19) and vaccination against SARS-CoV-2 can be responsible for thyroid disturbances.• Thyroid alterations discovered during acute COVID-19 tend to cease by time and only incidental thyroid autoimmunity (TA) is diagnosed after COVID-19. In adults, no increase in vaccine-related hyper- or hypothyroidism was found.

What is New:• TA rate after COVID-19 vaccination among children was not increased. TA had no role in long COVID syndrome.• We discovered a considerable rate of TA (6.6%) and ultrasound-proven autoimmune thyroiditis (AIT) (4.0%) after SARS-CoV-2 infection, and the majority of these alterations remained positive after 6 months.
An improved weighted mean of vectors algorithm for microgrid energy management considering demand response
Authors: Alamir Nehmedo , Kamel Salah , Hassan Mohamed H. , Abdelkader Sobhy M. 
Published: July 2023

AbstractThe integration of demand response programs (DRPs) into the energy management (EM) system of microgrids (MGs) helps in improving the load characteristics by allowing consumers to interoperate for achieving techno-economic advantages. In this paper, an improved algorithm is called LINFO is proposed for modifying search ability of the original weIghted meaN oF vectOrs (INFO) algorithm as well as avoiding its weaknesses like trapping in a local optima. The improved algorithm's efficiency is confirmed by comparing its results with those obtained by the original INFO and other optimization techniques using different standard benchmark test functions. Moreover, this improved algorithm and the original version are applied for solving the EM problem with the aim of optimizing the operation cost of the MGs in the presence DRPs. They are used to solve day-ahead EM problem for optimal operation of renewable energy resources, the optimal generation from a conventional diesel engines (DEs); taking into account the participation of customers in DRP for minimizing MG operating cost, which includes the cost of DEs fuel and the power transactions cost with the main grid. To demonstrate the efficacy of the proposed LINFO, simulation results are compared with the results of well-known and newly developed optimization techniques.
Attribute disclosure risk for k-anonymity: the case of numerical data
Authors: Torra Vicenç , Navarro-Arribas Guillermo 
Published: July 2023

Abstractk-Anonymity is one of the most well-known privacy models. Internal and external attacks were discussed for this privacy model, both focusing on categorical data. These attacks can be seen as attribute disclosure for a particular attribute. Then, p-sensitivity and p-diversity were proposed as solutions for these privacy models. That is, as a way to avoid attribute disclosure for this very attribute. In this paper we discuss the case of numerical data, and we show that attribute disclosure can also take place. For this, we use well-known rules to detect sensitive cells in tabular data protection. Our experiments show that k-anonymity is not immune to attribute disclosure in this sense. We have analyzed the results of two different algorithms for achieving k-anonymity. First, MDAV as a way to provide microaggregation and k-anonymity. Second, Mondrian. In fact, to our surprise, the number of cells detected as sensitive is quite significant, and there are no fundamental differences between Mondrian and MDAV. We describe the experiments considered, and the results obtained. We define dominance rule compliant and p%-rule compliant k-anonymity for k-anonymity taking into account attribute disclosure. We conclude with an analysis and directions for future research.
Sclerostin and Cardiovascular Disease
Authors: Tobias Jonathan H. 
Published: July 2023

Abstract
Purpose of Review
The role of wnt signalling in atherogenesis raises the possibility that the wnt inhibitor, sclerostin, provides a natural defence to this process, and that anti-sclerostin antibodies might increase the risk of atherosclerosis and associated conditions such as CVD. This article aims to triangulate evidence concerning possible adverse effects of sclerostin inhibition on CVD risk.

Recent Findings
Randomised controlled trials of treatment with the anti-sclerostin antibody, romosozumab, have yielded conflicting evidence with respect to possible adverse effects of sclerostin inhibition on CVD risk. To further examine the causal relationship between sclerostin inhibition and CVD risk, three Mendelian randomisation (MR) studies have examined effects of sclerostin lowering on CVD outcomes, using common genetic variants in the SOST gene which produces sclerostin, to mimic effects of a randomised trial. Concordant findings were seen in two studies, comprising an effect of sclerostin lowering on increased risk of MI and type II diabetes mellitus. One study also suggested that sclerostin lowering increases coronary artery calcification.

Summary
Triangulation of evidence from different sources provides some suggestion that sclerostin lowering increases MI risk, supporting the need for CVD risk assessment when considering treatment with romosozumab.
From an ellipsoid-based to an anthropomorphic articulated total body model for multibody applications
Authors: Pascoletti G. , Huysmans T. , Molenbroek J. F. M. , Zanetti E. M. 
Published: July 2023

AbstractHuman computer models represent a useful tool for investigating the human body response to external static/dynamic loads or for human-centred design. Articulated Total Body (ATB) models are the simplest human multibody models, where body segments are represented by ellipsoids joined at skeletal articulations. Over the years, regression models on both living subjects’ and cadavers’ data have been developed to predict body segments properties. These models are affected by two main limitations: the only inputs are the subject’s weight and height, not considering that for the same combination different morphologies can exist; secondly, regression analyses were performed over a specific population not including peculiar morphologies (under-weight or obese). A novel methodology for developing anthropomorphic ATB models is here presented: a statistical shape model able to predict the external geometry of the human body from a limited set of anthropometric measurements was implemented and body segments were obtained by segmentation; the respective inertial properties were computed from volumes, assuming a constant density value. The properties of this new anthropomorphic ATB model were compared to those calculated by GEBOD (Generator of Body Data), a well-known programme for ATB data calculation. A virtual population of twenty subjects was analysed: with reference to the inertial properties the most relevant differences occurred at the abdomen and the thighs segments (60% relative error), while the trunk, the shoulder and the calves represent the most critical areas for the geometry reconstruction (50 mm average error). The significance of these outcomes was investigated performing multibody simulations with various scenarios.
Environmental Risk Factors, Protective Factors, and Biomarkers for Allergic Rhinitis: A Systematic Umbrella Review of the Evidence
Authors: Xu Xianpeng , Liu Xinghong , Li Jiongke , Deng Xinxing , Dai Tianrong , Ji Qingjie , Xiong Dajing , Xie Hui 
Published: July 2023

AbstractMany potential environmental risk factors, protective factors, and biomarkers of AR have been published, but so far, the strength and consistency of their evidence are unclear. We conducted a comprehensive review of environmental risk, protective factors, and biomarkers for AR to establish the evidence hierarchy. We systematically searched Embase, PubMed, Cochrane Library, and Web of Science electronic database from inception to December 31, 2022. We calculated summary effect estimate (odds ratio (OR), relative risk (RR), hazard ratio (HR), and standardized mean difference (SMD)), 95% confidence interval, random effects p value, I2 statistic, 95% prediction interval, small study effects, and excess significance biases, and stratification of the level of evidence. Methodological quality was assessed by AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews 2). We retrieved 4478 articles, of which 43 met the inclusion criteria. The 43 eligible articles identified 31 potential environmental risk factors (10,806,206 total population, two study not reported), 11 potential environmental protective factors (823,883 total population), and 34 potential biomarkers (158,716 total population) for meta-analyses. The credibility of evidence was convincing (class I) for tic disorders (OR = 2.89, 95% CI 2.11–3.95); and highly suggestive (class II) for early-life antibiotic use (OR = 3.73, 95% CI 3.06–4.55), exposure to indoor dampness (OR = 1.49, 95% CI 1.27–1.75), acetaminophen exposure (OR = 1.54, 95% CI 1.41–1.69), childhood acid suppressant use (OR = 1.40, 95% CI 1.23–1.59), exposure to indoor mold (OR = 1.66, 95% CI 1.26–2.18), coronavirus disease 2019 (OR = 0.11, 95% CI 0.06–0.22), and prolonged breastfeeding (OR = 0.72, 95% CI 0.65–0.79). This study is registered in PROSPERO (CRD42022384320).