bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forward perspective on the development and strategic pathway of green hydrogen in China
Authors: Liu Guoyue 
Published: February 2023

Abstract
Fundamental transformations are taking place in the areas of energy structure on the supply side and on the energy-consumption side towards clean, low-carbon and safe energy. Furthermore, a new energy system is being constructed with renewable energy as its core in China with energy transition and ‘carbon peak and carbon neutral’ as the overall goal. China’s hydrogen-industry plan, ‘Mid-to-long term hydrogen industry development plan (2021–2035)’, has an emphasis on hydrogen generation by using renewable energies as the centre piece, which points in the right direction for hydrogen’s green development. In this paper, the current status of China’s hydrogen industry is analysed; strategic needs for green hydrogen’s development and its hurdles in its paths are sorted out. Integrated demonstration at provincial levels, development of a ‘great hydrogen base’ and the green-hydrogen development path by gradual substitution with renewable hydrogen are proposed. Scaled-up hydrogen production, expanded consumer hydrogen usage and established hydrogen commodity exchange are recommended to safeguard its development and promote its high-quality development in China.
Activating words without language: beta and theta oscillations reflect lexical access and control processes during verbal and non-verbal object recognition tasks
Authors: Branzi Francesca M , Martin Clara D , Biau Emmanuel 
Published: February 2023

AbstractThe intention to name an object modulates neural responses during object recognition tasks. However, the nature of this modulation is still unclear. We established whether a core operation in language, i.e. lexical access, can be observed even when the task does not require language (size-judgment task), and whether response selection in verbal versus non-verbal semantic tasks relies on similar neuronal processes. We measured and compared neuronal oscillatory activities and behavioral responses to the same set of pictures of meaningful objects, while the type of task participants had to perform (picture-naming versus size-judgment) and the type of stimuli to measure lexical access (cognate versus non-cognate) were manipulated. Despite activation of words was facilitated when the task required explicit word-retrieval (picture-naming task), lexical access occurred even without the intention to name the object (non-verbal size-judgment task). Activation of words and response selection were accompanied by beta (25–35 Hz) desynchronization and theta (3–7 Hz) synchronization, respectively. These effects were observed in both picture-naming and size-judgment tasks, suggesting that words became activated via similar mechanisms, irrespective of whether the task involves language explicitly. This finding has important implications to understand the link between core linguistic operations and performance in verbal and non-verbal semantic tasks.
Mild hypothermia attenuates ischaemia/reperfusion injury: insights from serial non-invasive pressure–volume loops
Authors: Berg Jonathan , Jablonowski Robert , Nordlund David , Ryd Daniel , Heiberg Einar , Carlsson Marcus , Arheden Håkan 
Published: February 2023

Abstract

Aims
Mild hypothermia, 32–35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries, but human trials have been ambiguous. To elucidate the cardioprotective mechanisms of mild hypothermia, we analysed cardiac performance in a porcine model of ischaemia/reperfusion, with serial cardiovascular magnetic resonance (CMR) imaging throughout 1 week using non-invasive pressure–volume (PV) loops.

Methods and results
Normothermia and Hypothermia group sessions (n = 7 + 7 pigs, non-random allocation) were imaged with Cardiovascular magnetic resonance (CMR) at baseline and subjected to 40 min of normothermic ischaemia by catheter intervention. Thereafter, the Hypothermia group was rapidly cooled (mean 34.5°C) for 5 min before reperfusion. Additional CMR sessions at 2 h, 24 h, and 7 days acquired ventricular volumes and ischaemic injuries (unblinded analysis). Stroke volume (SV: −24%; P = 0.029; Friedmans test) and ejection fraction (EF: −20%; P = 0.068) were notably reduced at 24 h in the Normothermia group compared with baseline. In contrast, the decreases were ameliorated in the Hypothermia group (SV: −6%; P = 0.77; EF: −6%; P = 0.13). Mean arterial pressure remained stable in Normothermic animals (−3%, P = 0.77) but dropped 2 h post-reperfusion in hypothermic animals (−18%, P = 0.007). Both groups experienced a decrease and partial recovery pattern for PV loop-derived variables over 1 week, but the adverse effects tended to attenuate in the Hypothermia group. Infarct sizes were 10 ± 8% in Hypothermic and 15 ± 8% in Normothermic animals (P = 0.32). Analysis of covariance at 24 h indicated that hypothermia has cardioprotective properties incremental to reducing infarct size, such as higher external power (P = 0.061) and lower arterial elastance (P = 0.015).

Conclusion
Using non-invasive PV loops by CMR, we observed that mild hypothermia at reperfusion alleviates the heart’s work after ischaemia/reperfusion injuries during the first week and preserves short-term cardiac performance. This hypothesis-generating study suggests hypothermia to have cardioprotective properties, incremental to reducing infarct size. The primary cardioprotective mechanism was likely an afterload reduction acutely unloading the left ventricle.
Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions
Authors: Uzzan Mathieu , Bouhnik Yoram , Abreu Maria , Ahmad Harris A , Adsul Shashi , Carlier Hilde , Dubinsky Marla , Germinaro Matthew , Jairath Vipul , Modesto Irene , Mortensen Eric , Narula Neeraj , Neimark Ezequiel , Oortwijn Alessandra , Protic Marijana , Rubin David T , Oh Young S , Wichary Jolanta , Peyrin-Biroulet Laurent , Reinisch Walter 
Published: February 2023

Abstract

Background
Rates of enrolment in clinical trials in inflammatory bowel disease [IBD] have decreased dramatically in recent years. This has led to delays, increased costs and failures to develop novel treatments.

Aims
The aim of this work is to describe the current bottlenecks of IBD clinical trial enrolment and propose solutions.

Methods
A taskforce comprising experienced IBD clinical trialists from academic centres and pharmaceutical companies involved in IBD clinical research predefined the four following levels: [1] study design, [2] investigative centre, [3] physician and [4] patient. At each level, the taskforce collectively explored the reasons for declining enrolment rates and generated an inventory of potential solutions.

Results
The main reasons identified included the overall increased demands for trials, the high screen failure rates, particularly in Crohn’s disease, partly due to the lack of correlation between clinical and endoscopic activity, and the use of complicated endoscopic scoring systems not reflective of the totality of inflammation. In addition, complex trial protocols with restrictive eligibility criteria, increasing burden of procedures and administrative tasks enhance the need for qualified resources in study coordination. At the physician level, lack of dedicated time and training is crucial. From the patients’ perspective, long washout periods from previous medications and protocol requirements not reflecting clinical practice, such as prolonged steroid management and placebo exposures, limit their participation in clinical trials.

Conclusion
This joint effort is proposed as the basis for profound clinical trial transformation triggered by investigative centres, contract research organizations, sponsors and regulatory agencies.
Web Vibrations in Intraspecific Contests of Female Black Widow Spiders,Latrodectus hesperus
Authors: Krugner Rodrigo , Espindola Crystal , Justus Nathan , Hatton Ross L 
Published: February 2023

AbstractFemale black widow spiders, Latrodectus hesperus Chamberlin and Ivie (Araneae: Theridiidae), are solitary predators of arthropods with no tolerance for intruders on the webs. In California, L. hesperus are found in urban and agricultural settings and can be a phytosanitary pest in fresh produce. Spatial separation of L. hesperus webs could be determined by seasonal population densities, with territorial competition expected under high densities in the environment. However, little is known about female-female communication behaviors in this species. In 1-hr laboratory observations, displays of female-female rivalry included production of vibrational signals in a majority (20 of 30) of trials. The number of signals produced by both females was highest during the initial 10 min of trials, with signaling rate (time interval between signals) peaking during the 40–50 min observation period. The overall ratio of signals produced by the resident female and the introduced female was about 5:1, with the number of signals produced by the resident female higher than the number of signals produced by the introduced female. Analysis of rivalry signals showed a peak in magnitude (about 0.4 m/s) ranging from 6 to 23 Hz and smaller peaks at about 29, 38, and 47 Hz. Collectively, these results demonstrate that female L. hesperus exhibit territorial rivalry and that female-female rivalry is mediated by emission of vibrational signals through the web. Understanding the mechanisms of intraspecific competition in L. hesperus is required for elucidating interspecific interactions in the environment and may lead to development of novel methods to prevent spiders from colonizing crops.
Deep learning estimation of three-dimensional left atrial shape from two-chamber and four-chamber cardiac long axis views
Authors: Xu Hao , Williams Steven E , Williams Michelle C , Newby David E , Taylor Jonathan , Neji Radhouene , Kunze Karl P , Niederer Steven A , Young Alistair A 
Published: February 2023

Abstract

Aims
Left atrial volume is commonly estimated using the bi-plane area-length method from two-chamber (2CH) and four-chamber (4CH) long axes views. However, this can be inaccurate due to a violation of geometric assumptions. We aimed to develop a deep learning neural network to infer 3D left atrial shape, volume and surface area from 2CH and 4CH views.

Methods and results
A 3D UNet was trained and tested using 2CH and 4CH segmentations generated from 3D coronary computed tomography angiography (CCTA) segmentations (n = 1700, with 1400/100/200 cases for training/validating/testing). An independent test dataset from another institution was also evaluated, using cardiac magnetic resonance (CMR) 2CH and 4CH segmentations as input and 3D CCTA segmentations as the ground truth (n = 20). For the 200 test cases generated from CCTA, the network achieved a mean Dice score value of 93.7%, showing excellent 3D shape reconstruction from two views compared with the 3D segmentation Dice of 97.4%. The network also showed significantly lower mean absolute error values of 3.5 mL/4.9 cm2 for LA volume/surface area respectively compared to the area-length method errors of 13.0 mL/34.1 cm2 respectively (P &lt; 0.05 for both). For the independent CMR test set, the network achieved accurate 3D shape estimation (mean Dice score value of 87.4%), and a mean absolute error values of 6.0 mL/5.7 cm2 for left atrial volume/surface area respectively, significantly less than the area-length method errors of 14.2 mL/19.3 cm2 respectively (P &lt; 0.05 for both).

Conclusions
Compared to the bi-plane area-length method, the network showed higher accuracy and robustness for both volume and surface area.
Israeli Courts and the Paradox of International Human Rights Law
Authors: Davidson Natalie R , Hostovsky Brandes Tamar 
Published: February 2023

Abstract
This article offers the first comprehensive mapping of the place of international human rights law (IHRL) in Israeli case law. It explores how Israeli courts use IHRL, based on quantitative and qualitative content analysis of all decisions, in all courts, referring to IHRL between 1990 and 2019. It reveals that Israeli courts mobilize IHRL predominantly with respect to children’s rights and due process, seldom invoking IHRL in relation to ethnic and gender equality. It further shows that a significant portion of references to IHRL serve to justify state action. We discuss possible explanations for these patterns of use of IHRL and argue that, overall, these findings illustrate the paradox of IHRL being amenable to uses that are both emancipatory and protective of power.
Women in European academia before 1800—religion, marriage, and human capital
Authors: de la Croix David , Vitale Mara 
Published: February 2023

Abstract
We document the participation of women in European academia from the first universities to the eve of the Industrial Revolution. A total of 108 women taught at universities or were members of academies of arts and sciences. Most of them were active in Catholic southern Europe—an unexpected result. We conjecture that Protestantism left less room for women at the top of the distribution of human capital to exercise their talent. The percentage of ever-married female scholars is 79%, but a large fraction of them remained childless. Comparing them with 58,995 male scholars, we find that they were on average better.
Signals, educational decision-making, and inequality: a comment on the formal model by Holm, Hjorth-Trolle, and Jæger
Authors: Yastrebov Gordey 
Published: February 2023

Abstract
In this comment, I explore the assumptions and the implications of the formal (mathematical) model proposed by Holm, Hjorth-Trolle, and Jæger (HHJ) in their article in European Sociological Review, 35(4) (2019). The model links educational decision-making to social background inequality and academic ability and is said to conform to the key propositions of the Relative-Risk-Aversion theory and the Compensatory-Advantage-Model. Its most original component is that it allows for the error in estimating one’s ability, which, once known, impacts on the decision to (dis)continue education. The error is said to have a differential impact on students of different social backgrounds, whereby social inequality in educational decisions is effectively maintained. The model also deserves attention and praise as one of the few attempts in our field to reason formally and provide a mathematical formulation of theoretical arguments. However, I scrutinize the model and show that (i) some of its assumptions may not be defensible; that (ii) the most interesting and original hypothesis proposed by HHJ does not follow from the model; and that (iii) the empirical implications of the model are wrongly interpreted in terms of probability differences. I then show which particular assumption is required for HHJ’s most original hypothesis to hold. The assumption is non-intuitive, and I conclude that the hypothesis, as formulated by HHJ, does not have a sound theoretical basis.
Outcomes in novel hospital-at-home model for patients with COVID-19: a multicentre retrospective cohort study
Authors: Tsujimoto Yasushi , Kobayashi Masanori , Oku Tomohisa , Ogawa Takahisa , Yamadera Shinichi , Tsukamoto Masako , Matsuda Noriya , Nishihira Morikazu , Terauchi Yu , Tanaka Takahiro , Kawabata Yoshitaka , Miyamoto Yuki , Morikami Yoshiki ,   KISA2-Tai Osaka
Published: February 2023

Abstract

Background
Hospital-at-home (HaH) care has been proposed as an alternative to inpatient care for patients with coronavirus disease (COVID-19). Previous reports were hospital-led and involved patients triaged at the hospitals. To reduce the burden on hospitals, we constructed a novel HaH care model organized by a team of local primary care clinics.

Methods
We conducted a multicentre retrospective cohort study of the COVID-19 patients who received our HaH care from 1 January to 31 March 2022. Patients who were not able to be triaged for the need for hospitalization by the Health Center solely responsible for the management of COVID-19 patients in Osaka city were included. The primary outcome was receiving medical care beyond the HaH care defined as a composite outcome of any medical consultation, hospitalization, or death within 30 days from the initial treatment.

Results
Of 382 eligible patients, 34 (9%) were triaged for hospitalization immediately after the initial visit. Of the remaining 348 patients followed up, 37 (11%) developed the primary outcome, while none died. Obesity, fever, and gastrointestinal symptoms at baseline were independently associated with an increased risk of needing medical care beyond the HaH care. A further 129 (37%) patients were managed online alone without home visit, and 170 (50%) required only 1 home visit in addition to online treatment.

Conclusions
The HaH care model with a team of primary care clinics was able to triage patients with COVID-19 who needed immediate hospitalization without involving hospitals, and treated most of the remaining patients at home.
Perceived importance and interest in research by Chilean primary care providers
Authors: García-Huidobro Diego , Aracena Marcela , Bravo Paulina , González Karla , Soto Mauricio , von Borries Pamela , Sapag Jaime C 
Published: February 2023

Abstract

Background
Primary care providers (PCPs) are relevant stakeholders for primary care research (PCR).

Objective
We report the perceived importance and interest in PCR of a national sample of Chilean PCPs.

Methods
We conducted a cross-sectional study targeting Chilean PCPs. An electronic survey assessing perceived relevance of PCR, research training and experience, training interests, and demographics was disseminated through emails and WhatsApp messages. Descriptive statistics were used to summarize data. Logistic regression models were used to estimate adjusted probabilities and 95% confidence intervals for high interest in PCR, high interest in using research methods, and high interest in receiving research training, and predictors of these outcomes.

Results
A total of 387 providers completed the online survey. Only 26.4% of PCPs had research experience as a principal or co-investigator. However, most clinicians perceived PCR as very important (92.5%) and were interested in using research methods (90.7%) and receiving training (94.3%). There were no statistically significant differences in these perceptions between provider’s discipline, role, sex, age, and geographical location after adjusting for covariates.

Conclusions
Despite few Chilean PCPs have research training, a large majority perceive it as important, are interested in using it in their practice and would like to receive training.
Impacts of coniferous bark-derived organic soil amendments on microbial communities in arable soil – a microcosm study
Authors: Peltoniemi Krista , Velmala Sannakajsa , Fritze Hannu , Jyske Tuula , Rasi Saija , Pennanen Taina 
Published: February 2023

AbstractA decline in the carbon content of agricultural soils has been reported globally. Amendments of forest industry side-streams might counteract this. We tested the effects of industrial conifer bark and its cascade process materials on the soil microbiome under barley (Hordeum vulgare L.) in clay and silt soil microcosms for 10 months, simulating the seasonal temperature changes of the boreal region. Microbial gene copy numbers were higher in clay soils than in silt. All amendments except unextracted bark increased bacterial gene copies in both soils. In turn, all other amendments, but not unextracted bark from an anaerobic digestion process, increased fungal gene copy numbers in silt soil. In clay soil, fungal increase occurred only with unextracted bark and hot water extracted bark. Soil, amendment type and simulated season affected both the bacterial and fungal community composition. Amendments increased bacteria originating from the anaerobic digestion process, as well as dinitrogen fixers and decomposers of plant cells. In turn, unextracted and hot water extracted bark determined the fungal community composition in silt. As fungal abundance increase and community diversification are related to soil carbon acquisition, bark-based amendments to soils can thus contribute to sustainable agriculture.
From the organismal to biosphere levels: environmental impacts on the amphibian microbiota
Authors: Hernández-Gómez Obed , Hua Jessica 
Published: February 2023

Abstract
This review summarizes the role of environmental factors on amphibian microbiotas at the organismal, population, community, ecosystem, and biosphere levels. At the organismal-level, tissue source, disease status, and experimental manipulations were the strongest predictors of variation in amphibian microbiotas. At the population-level, habitat quality, disease status, and ancestry were commonly documented as drivers of microbiota turnover. At the community-level, studies focused on how species’ niche influence microbiota structure and function. At the ecosystem-level, abiotic and biotic reservoirs were important contributors to microbiota structure. At the biosphere-level, databases, sample banks, and seminatural experiments were commonly used to describe microbiota assembly mechanisms among temperate and tropical amphibians. Collectively, our review demonstrates that environmental factors can influence microbiotas through diverse mechanisms at all biological scales. Importantly, while environmental mechanisms occurring at each of the different scales can interact to shape microbiotas, the past 10 years of research have mostly been characterized by targeted approaches at individual scales. Looking forward, efforts considering how environmental factors at multiple organizational levels interact to shape microbiota diversity and function are paramount. Generating opportunities for meaningful cross-disciplinary interactions and supporting infrastructure for research that spans biological scales are imperative to addressing this gap.
Effects of providing tailored information about e-cigarettes in a digital smoking cessation intervention: randomized controlled trial
Authors: Elling J M , Crutzen R , Talhout R , de Vries H 
Published: February 2023

AbstractThe effectiveness of e-cigarettes in smoking cessation is under debate. Informing smokers who are motivated to quit smoking about e-cigarettes may help them to make an informed decision about their use for smoking cessation, which, however, may also lead to unintended effects such as less quitting. This experimental study assessed the influence of providing tailored information about e-cigarettes in a web-based tailored smoking cessation intervention on participants’ decision-making and smoking behavior. Adult smokers (N = 331) were randomized into a personalized eHealth intervention on (i) smoking cessation (control condition) or (ii) smoking cessation and information about e-cigarettes (intervention condition). Directly postintervention, participants in the intervention condition had more knowledge about e-cigarettes than participants in the control condition. Attitudes toward e-cigarettes were more positive among intervention participants than control participants, but the differences in attitude were less pronounced than the differences in knowledge and not consistent across items. At a 6-month follow-up, no between-condition differences were observed in the use of e-cigarettes as a smoking cessation method, the number of tobacco cigarettes smoked in the past 7 days, or other smoking outcomes.