bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening and confirmation tests for SARS-CoV-2: benefits and drawbacks
Authors: Shafie Muhammad Hakimin , Antony Dass Marie , Ahmad Shaberi Hazlam Shamin , Zafarina Zainuddin 
Published: January 2023

Abstract
Background
Coronavirus disease 2019 is a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection that emerged in late 2019 and has activated an ongoing international public health emergency. SARS-CoV-2 was discovered in Wuhan, China, in December 2019 and rapidly spread to other cities and countries. Currently, SARS-CoV-2 diagnostic tests have relied heavily on detecting viral genes, antigens, and human antibodies. Hence, this review discusses and analyses the existing screening and confirmation tests for SARS-CoV-2, including the real-time reverse transcriptase polymerase chain reaction (RT-PCR), lateral flow immunoassay (LFIA), and enzyme-linked immunosorbent assay (ELISA).

Main body
The illustrations of each testing were presented to provide the readers with an understanding of the scientific principles behind the testing methods. The comparison was made by highlighting the advantages and disadvantages of each testing. ELISA is ideal for performing the maximum population screening to determine immunological capacity, although its inability to provide reliable results on the status of the infection. Recently, LFIA has been approved as a quicker way of determining whether a patient is infected at the analysis time without using particular instruments and non-laboratory settings. RT-PCR is the gold-standard approach in terms of sensitivity and specificity.

Conclusion
However, the combination of LFIA or ELISA with RT-PCR is also proposed in this review to obtain an adequate level of sensitivity and specificity.

Graphic Abstract
A Forest, a Maze, a Garden, a City
Authors: Fitzgerald Des 
Published: January 2023

Abstract
This article argues for a mutation in how mental health is conceived in the early twenty-first century. In this mutation, physical environments, in the form of homes, workplaces, and streetscapes, are understood as central to the production and maintenance of good mental health. Much writing on this topic has taken place within a rhetorical division between stereotypically urban buildings or spaces (tower blocks, for example), which are said to be harmful to the human mind, and idealized rural or green spaces, such as parks or small hamlets, understood to be psychologically restorative. This discourse, which has its roots in both cultural and scientific developments, has rendered mental disorder as, at least in part, a spatial problem—which is to say, as a problem that might be both understood through but also treated by spatial practices. The goal of the article is to establish the ground of this claim and to make some of its epistemic roots visible. The article begins with an ethnographic account of a contemporary intellectual movement aimed at populating urban spaces with trees in the name of global mental health. Then the discussion turns to a series of critical developments in the psychological and neurobiological sciences—the article demonstrates how these, in turn, are efflorescing into new links between the architectural and psychological sciences. The article shows how this scientific discussion is paralleled by developments in urban planning—Ebenezer Howard's program of the early twentieth century, set out in Garden Cities of To-Morrow, is taken as exemplary here. The article ends with a reading of Clive Barker's 1985 short story “The Forbidden” and of the film Candyman, which it gave rise to, whose shared sense of horror at the visceral consequences of failed urban experiments, I argue, should be read as a critical inflection point for the contemporary relationship between psychology and architecture.
Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation
Authors: Chandran Lenin , Backer Wilko , Schleutker Raphael , Kong Deqing , Beati Seyed A. H. , Luschnig Stefan , Müller H.-Arno J. 
Published: January 2023

ABSTRACT
Src kinases are important regulators of cell adhesion. Here, we have explored the function of Src42A in junction remodelling during Drosophila gastrulation. Src42A is required for tyrosine phosphorylation at bicellular (bAJ) and tricellular (tAJ) junctions in germband cells, and localizes to hotspots of mechanical tension. The role of Src42A was investigated using maternal RNAi and CRISPR-Cas9-induced germline mosaics. We find that, during cell intercalations, Src42A is required for the contraction of junctions at anterior-posterior cell interfaces. The planar polarity of E-cadherin is compromised and E-cadherin accumulates at tricellular junctions after Src42A knockdown. Furthermore, we show that Src42A acts in concert with Abl kinase, which has also been implicated in cell intercalations. Our data suggest that Src42A is involved in two related processes: in addition to establishing tension generated by the planar polarity of MyoII, it may also act as a signalling factor at tAJs to control E-cadherin residence time.
Time Inconsistency and Financial Covenants
Authors: Xiang Haotian 
Published: January 2023

Financial covenants influence firm behavior by state-contingently allocating decision rights. I develop a quantitative model with long-term debt where shareholders cannot commit to not dilute existing lenders with new debt issuances. Lenders intervene on covenant violations but cannot commit either to any debt restructuring plan ex ante. Counterfactual experiments suggest that financial covenants significantly reduce default probability and increase firm value. However, the value creation is limited by lenders’ limited commitment. A hump-shaped relation between covenant tightness and firm value emerges, reflecting a balance between limited commitment on two sides. This paper was accepted by Gustavo Manso, finance. Supplemental Material: The data files and online appendices are available at https://doi.org/10.1287/mnsc.2022.4667 .
Off-Platform Threats in On-Demand Services
Authors: He Eryn Juan , Savin Sergei , Goh Joel , Teo Chung-Piaw 
Published: January 2023

Problem definition: Online platforms that provide on-demand services are often threatened by the phenomenon of leakage, where customer-provider pairs may decide to transact “off-platform” to avoid paying commissions to the platform. This paper investigates properties of services that make them vulnerable or resistant to leakage. Academic/practical relevance: In practice, much attention has been given to platform leakage, with platforms experimenting with multiple approaches to alleviate leakage and maintain their customer and provider bases. Yet, there is a current dearth of studies in the operations literature that systematically analyze the key factors behind platform leakage. Our work fills this gap and answers practical questions regarding the sustainability of platform. Methodology: We develop two game-theoretical models that capture service providers’ and customers’ decisions whether to conduct transactions on or off the platform. In the first (“perfect information”) model, we assume that customers are equipped with information to select their desired providers on the platform, whereas in the second (“imperfect information”) model, we assume customers are randomly matched with available providers by the platform. Results: For profit maximizing platforms, we show that leakage occurs if and only if the value of the counterparty risk from off-platform transactions exceeds a threshold. Across both models, platforms tend to be more immunized against leakage as provider pool sizes increase, customer valuations for service increase, their waiting costs decrease, or variability in service times are reduced. Finally, by comparing the degree of leakage between both settings, we find that neither model dominates the other across all parameter combinations. Managerial implications: Our results provide guidance to existing platform managers or entrepreneurs who are considering “platforming” their services. Namely, based on a few key features of the operating environment, managers can assess the severity of the threat of platform leakage for their specific business context. Our results also suggest how redesigning the waiting process, reducing service time variability, upskilling providers can reduce the threat of leakage. They also suggest the conditions under which revealing provider quality information to customers can help to curb leakage. Funding: J. Goh’s work was supported by a National University of Singapore Start-Up [Grant R-314-000-110-133] and a 2021 Humanities and Social Sciences Fellowship from the National University of Singapore. Supplemental Material: The online appendices are available at https://doi.org/10.1287/msom.2022.1179 .
Surgical wound care preferences and priorities from the perspectives of patients: a qualitative analysis
Authors: Walker Rachel M , Rattray Megan , Lockwood Ishtar , Chaboyer Wendy , Lin France , Roberts Shelley , Perry Jodie , Birgan Sean , Nieuwenhoven Paul , Garrahy Elizabeth , Probert Rosalind , Gillespie Brigid M 
Published: January 2023

Objective: To explore patients' priorities and preferences for optimal care of their acute or hard-to-heal surgical wound(s). Method: This qualitative study involved semi-structured individual interviews with patients receiving wound care in Queensland, Australia. Convenience and snowball sampling were used to recruit patients from inpatient and outpatient settings between November 2019 and January 2020. Interviews were audio recorded, transcribed verbatim and analysed using thematic analysis. Emergent themes were discussed by all investigators to ensure consensus. Results: A total of eight patients were interviewed, five of whom were male (average median age: 70.5 years; interquartile range (IQR): 45–80 years). Four interrelated themes emerged from the data that describe the patients' surgical wound journey: experiencing psychological and psychosocial challenges; taking back control by actively engaging in care; seeking out essential clinician attributes; and collaborating with clinicians to enable an individualised approach to their wound care. Conclusion: Findings from this study indicate that patients want to actively collaborate with clinicians who have caring qualities, professional skills and knowledge, and be involved in decision-making to ensure care meets their individual needs.
A Novel Light-Weight DCNN Model for Classifying Plant Diseases on Internet of Things Edge Devices
Authors: Minh Hoang Trong , Anh Tuan Pham , Nhan Van Nguyen 
Published: January 2023

One of the essential aspects of smart farming and precision agriculture is quickly and accurately identifying diseases. Utilizing plant imaging and recently developed machine learning algorithms, the timely detection of diseases provides many benefits to farmers regarding crop and product quality. Specifically, for farmers in remote areas, disease diagnostics on edge devices is the most effective and optimal method to handle crop damage as quickly as possible. However, the limitations posed by the equipment’s limited resources have reduced the accuracy of disease detection. Consequently, adopting an efficient machine-learning model and decreasing the model size to fit the edge device is an exciting problem that receives significant attention from researchers and developers. This work takes advantage of previous research on deep learning model performance evaluation to present a model that applies to both the Plant-Village laboratory dataset and the Plant-Doc natural-type dataset. The evaluation results indicate that the proposed model is as effective as the current state-of-the-art model. Moreover, due to the quantization technique, the system performance stays the same when the model size is reduced to accommodate the edge device.
Hyperspectral camera as a compact payload architecture for remote sensing applications
Authors: Morales-Norato David , Urrea Sergio , Garcia Hans , Rodriguez-Ferreira Julian , Martinez Elizabeth , Arguello Henry , Silva-Lora Alberto , Torres Rafael , Acero Ignacio F. , Hernández Francisco L. , Cárdenas Lorena P. , Rincón Sonia 
Published: January 2023

Monitoring and observation over the surface of the Earth have been a matter of global interest. In this path, recent efforts aim to develop a spatial mission to perform remote sensing applications. Mainly, CubeSat nanosatellites have emerged as a standard for developing low-weight and small-sized instruments. In terms of payloads, state-of-the-art optical systems for CubeSats are expensive and designed to work in general use cases. To overcome these limitations, this paper presents a 1.4 U compact optical system to acquire spectral images from a CubeSat standard satellite at the height of 550 km. To validate the proposed architecture, optical simulations using ray tracing simulation software are presented. Because the performance of computer vision tasks is highly related to data quality, we compared the optical system in terms of the classification performance on a real remote sensing application. The performances of the optical characterization and land cover classification show that the proposed optical system achieves a compact instrument, operating at a spectral range from 450 nm to 900 nm discretized on 35 spectral bands. The optical system has an overall

f

-number of 3.41 with a ground sampling distance of 52.8 m and a swath of 40 km. Additionally, the design parameters for each optical element are publicly available for validation, repeatability, and reproducibility of the results.
Investigation of inlet air pressure and evaporative cooling of four different cogeneration cycles
Authors: Karaali Rabi 
Published: January 2023

Abstract
The objective of this study was to search the effects of the inlet air compressor pressure and evaporative cooling of four different cogeneration plants that are absorption cooling (ab), basic (bsc), air heating (airh), and air fuel heating (airfh) cogeneration systems by using the first law and the second law of thermodynamics, and the exergy analysis methods. For analysis, a program is written by the author in the FORTRAN programming language. Decreasing the atmospheric pressure or increasing the installation altitude of the plants increases the Z factor (ratio of lost exergy to useful exergy) of the four cycles about 10–13%. Also, decreasing inlet air pressure decreases the specific work about 25–28%, and the fuel energy saving ratio of the four cycles decreases about 29–30%. The method of water spray cooling of the compressor inlet air especially in the summer months, the humidity increases and the evaporative cooling can be obtained. By using this method, the ratio of lost exergy to useful exergy can be decreased for the four cycles about 0.5–2%. Also, the specific work of the four cycles can be increased about 1.2–6%.
Evaluation of academic detailing to educate clinicians regarding childhood lead poisoning prevention: a pilot study
Authors: Newman Nicholas C. , Knapke Jacqueline M. , Kiniyalocts Rachael , Belt John , Haynes Erin 
Published: January 2023

Abstract

Context
Environmental exposures are associated with approximately 19% of disease globally, and exposure to neurotoxic chemicals is estimated to cost the United States $50 billion per year. Despite calls from the Institute of Medicine to increase training for clinicians regarding environmental health since the 1990s, there is still little instruction in environmental health for clinicians. This leaves gaps in knowledge that need to be bridged through outreach and education to practicing clinicians. Academic detailing (AD) is an educational intervention associated with improved prescribing practices in healthcare professionals but has not been applied to preventive or environmental health. Childhood lead exposure is a common condition associated with lifetime increased risk of cognitive and behavioral problems. Ohio has more than 2 million homes built before 1978, making exposure to lead-based paint a significant public health problem; however, only 50% of high-risk children are tested for lead. Few receive health promotion information regarding lead poisoning prevention, in part because this is not a part of training for healthcare providers (HCPs).

Objectives
The objectives of this study were twofold: (1) implement a pilot of AD sessions on the topic of childhood lead poisoning prevention with frontline HCPs and their staff in different practice settings; and (2) evaluate the acceptability of these training sessions utilizing quantitative and qualitative methods.

Methods
Physicians, nurses, social workers, community health workers, and clinical office staff were recruited from clinics who care for children at high risk for lead exposure. Trainings consisting of small group AD style sessions were presented at these sites. Learning objectives included increasing knowledge regarding lead testing requirements, enabling identification of lead’s impact on child development and equipping participants to provide anticipatory guidance for parents regarding lead poisoning prevention. Participants provided feedback through an anonymous questionnaire and qualitative feedback.

Results
There were 46 participants (12 physicians in practice/in training, 21 nursing or office staff, and 13 community health or social workers); more than 90% of the participants reported that the training achieved its learning objectives. Small-group presentations were preferred (91%); approximately 39% of participants requested an online format. Participants preferred that the presenters be either a public health or lead clinical expert, and they suggested that future activities include clinical vignettes.

Conclusions
Academic-detailing style training shows promise in promoting childhood lead poisoning prevention for frontline HCPs.
DSD/intersex: historical context and current perspectives
Authors: Lee Peter A. , Mazur Tom , Houk Christopher P. 
Published: January 2023

Abstract
Intersex/Disorders/Differences of sex development conditions have been recognized for millennia. An organized approach was adopted in the 1960–70s using the philosophy that gender identity was fluid and malleable. Consequences of this approach were the lack of disclosure, stigmatization, and excessive surgery to “normalize” the genitalia. Often this led to quality of life issues for those patients. There have been many modifications in approach since then to avoid the problems noted. There is consensus on many of these changes (e.g. disclosure) but continued controversy on others (e.g. the benefits of early surgery). This review summarizes the historical context and the current areas of consensus and controversy.
Linguistic judgments in 3D: the aesthetic quality, linguistic acceptability, and surface probability of stigmatized and non-stigmatized variation
Authors: Schoenmakers Gert-Jan 
Published: January 2023

AbstractLinguistic judgment experiments typically elicit judgments in terms of the acceptability or surface probability of a sentence. There is evidence that the dimension of the scale on which sentences are judged influences the outcome of the experiment, but to date this evidence is only limited. This is not a trivial matter, as the elicited judgment data are increasingly considered the basis for inferences about linguistic representation. The present study investigates whether the dimension of the scale influences judgments. Sentences are judged in one of three dimensions:acceptability,probability, oraesthetics. Two distinct sets of experimental items are tested; one with cases of stigmatized variation (violations of the prescriptive norm) and another with cases of non-stigmatized variation (middle-field scrambling) in Dutch. The results show that participants take into account the scale dimension, both in stigmatized and in non-stigmatized variation. The results for stigmatized variation reflect a certain degree of conscious reflection based on the judgment scale; the effects in non-stigmatized variation, by contrast, are only main effects of instruction without changes in the relative pattern of judgments between conditions. These findings corroborate the idea that linguistic judgments of non-stigmatized variation are not the result of introspection in the technical sense, but automatic, multi-dimensional responses to a stimulus.
Model Experimental Study on Blasting Vibration Response of Tunnel Surrounding Rock under Different in Situ Stresses
Authors: Chen Shihai , Huang Jiang , Liu Minlong 
Published: January 2023

Abstract
Studying the propagation characteristics of blasting seismic waves in surrounding rock under different in situ stresses forms the basic framework for discussing the damage and failure laws of tunnel surrounding rock caused by deep engineering blasting vibration. To study the propagation law of blasting seismic waves under different in situ stresses, an underground engineering model test system is used to simulate tunnel blasting excavation with a nonexplosive electric spark initiation device. The vibration acceleration and strain of the surrounding rock during excavation are collected in real time. Based on the test data system, the blasting vibration response characteristics of tunnel surrounding rock under different in situ stresses are discussed. According to the results of experimental studies, the peak values of radial and axial acceleration show nonlinear attenuation with an increase in distance under different in situ stresses. With an increase in in situ stress, the attenuation rate of the peak value of radial acceleration decreases, while that of axial acceleration increases. Moreover, the peak values of acceleration and strain measured at the same point near the seismic source under different in situ stresses remain unchanged, whereas those measured at the same point far away from the seismic source gradually decrease. Moreover, the attenuation rate at the stage of low in situ stress is greater than that at the stage of high in situ stress. The farther away from the seismic source, the greater the influence of in situ stress on peak acceleration and peak strain. The research results play an important guiding role in the development of deep tunnel blasting theory and safe construction.