bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of the caregiver training literature for individuals with autism spectrum disorder
Authors: Kemmerer Ashley R. , Vladescu Jason C. , DeBar Ruth M. , Sidener Tina M. , Bell Marlesha C. 
Published: April 2023

AbstractBoth caregiver training and the collection of social validity data are considered to be important and integral part of applied behavior analytic treatment for individuals with autism spectrum disorder. Previous reviewers have offered repeated calls for increased frequency of social validity data collection but recently, the increased understanding and focus on equitable and culturally responsive behavior analytic treatment have again highlighted the importance of social validity data collection. One recent review of behavior analytic treatments for children of culturally and linguistically diverse backgrounds conducted an in‐depth analysis of social validity data collection. The authors found generally vague descriptions of social validity provided as well as data collected primarily after a study was conducted. No previous caregiver training reviews have specifically evaluated socially validity data collection within the context of caregiver training nor have they evaluated cultural responsiveness of the treatments. The current scoping review evaluated general findings on caregiver training as well as expanded the scope of previous reviews by providing an analysis of social validity data collection in caregiver training and variables to consider when providing culturally responsive treatment.
Evaluation of a break‐to‐choice chained‐schedule intervention for multiply maintained problem behavior
Authors: Livingston Cynthia P. , Melanson Isaac J. , Martinez Sarah , Anderson Heather 
Published: April 2023

AbstractInterventions for multiply maintained problem behavior often involve developing separate treatment conditions to address each function. Although isolating treatment conditions lead to positive outcomes, developing individual treatments for each identified function may be time‐consuming. Alternatively, synthesizing treatment procedures may allow for more efficient treatment effects. We extended previous research by evaluating functional communication training (FCT) and chained schedules of reinforcement to treat multiply maintained problem behavior in children diagnosed with autism spectrum disorder. First, we conducted a functional analysis that concluded problem behavior was multiply maintained. Next, we taught functional communication responses (FCRs) and implemented a chained schedule of reinforcement. During the initial link, FCRs for a break resulted in the presentation of a choice menu with the other putative reinforcers in the terminal link. The relevant reinforcer was delivered contingent on the emission of subsequent FCRs. Finally, we systematically schedule thinned to caregiver‐informed terminal schedules for each participant. The results of our study demonstrated that FCT, in combination with a sequential compound schedule of reinforcement, effectively decreased multiply maintained problem behavior and increased appropriate alternative responses (FCRs and compliance) even at terminal schedules of reinforcement.
The forensic assessment of dissociation: Distinguishing real from the unreal
Authors: Scott Charles L. , Salem Amanie M. , Tindell William W. , Neely Hunter K. , Blum Austin W. 
Published: April 2023

AbstractBecause a wide range of disorders incorporate dissociative symptoms, evaluators should be familiar with evidence‐based approaches to evaluating dissociation claims in the clinical and forensic context. This article provides specific guidelines for practitioners when conducting a forensic assessment of individuals who report dissociative symptoms. We review the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition disorders that include dissociation as a symptom, highlight how to distinguish genuine versus atypical symptoms of dissociative identity disorder, and summarize strengths and weaknesses of structured assessments in the evaluation of dissociative claims.
FerryCalin: an Engineered Lipocalin Protein Directed against the Transferrin Receptor with Potential for Brain Drug Delivery
Authors: Nästle Lea , Deuschle Friedrich‐Christian , Morath Volker , Skerra Arne 
Published: April 2023

AbstractThe transferrin receptor (TfR) mediates transcytosis across the blood‐brain barrier (BBB), which offers a promising approach for the non‐invasive delivery of therapeutics into the brain parenchyma. Employing the recombinant homodimeric murine TfR ectodomain, prepared in a biochemically functional state, we have selected a cognate Anticalin via phage display and bacterial cell surface display from a random library based on the human lipocalin 2 (Lcn2). After affinity maturation, several engineered lipocalin variants were identified that bind murine TfR in a non‐competitive manner with the natural ligand (transferrin ⋅ Fe3+), among those an Anticalin – dubbed FerryCalin – exhibiting a dissociation constant (KD) of 3.8 nM. Epitope analysis using the SPOT technique revealed a sequential epitope in a surface region of TfR remote from the transferrin‐binding site. Due to the fast kon rate and short complex half‐life, as evidenced by real‐time surface plasmon resonance (SPR) measurements, FerryCalin, or one of its related mutants, shows characteristics as a potential vehicle for the brain delivery of biopharmaceuticals.
Structural Investigation of Small Nickel‐Ethanol Clusters Using Vibrational Spectroscopy in a Molecular Beam
Authors: Dietrich Fabian , Becherer Markus , Bellaire Daniel , Gerhards Markus 
Published: April 2023

AbstractThe structural identification of small nickel clusters with ethanol can help to understand fundamental steps for heterogenous catalysis. We investigate the rows [Nix(EtOH)1]+ with x=1–4, and [Ni2(EtOH)y]+ with y=1–3 via IR photodissociation spectroscopy in a molecular beam experiment. Analyzing the CH‐ and OH‐stretching frequencies and comparing these experimental results with density functional theory (DFT) calculations on the PW91/6‐311+G(d,p) level leads to the identification of intact motifs for all clusters and hints for C−O cleavage of the ethanol in two particular cases. Furthermore, we analyze the effects of frequency shifts with the increasing clusters sizes using the results of natural bond orbitals (NBO) analyses and an energy decomposition method.
Sex differences in the relationship between platelet count and type 2 diabetes risk in community‐dwelling adults: Longitudinal findings over 14 years
Authors: Yun Eun Kyeong , Seo In‐Ho , Lee Hye Sun , Seol So‐Young , Lee Yong‐Jae 
Published: April 2023

AbstractAimsEmerging evidence suggests that platelet count predicts the development of type 2 diabetes; however, there is conflicting evidence concerning the relationship in men and women. This study aimed to assess the longitudinal association between platelet count and the incidence risk of type 2 diabetes.Materials and MethodsAmong 10,030 participants, 7325 participants (3439 men and 3886 women) without diabetes were selected from the Korean Genome and Epidemiology Study. Platelet count quartiles were divided as follows: Q1 ≤219, Q2, 220–254, Q3, 255–296 and Q4 ≥297 (x103/ml) for men and ≤232, 233–266, 267–305 and ≥306 (x103/μL) for women. The hazard ratios (HRs) with 95% confidential intervals (CIs) for incident type 2 diabetes were calculated using multiple Cox proportional hazards regression models according to sex‐specific platelet count quartiles.ResultsDuring the biennial follow‐up period from 2001 to 2002 to 2013–2014, 750 male participants (21.8%, 750/3439) and 730 female participants (18.8%, 730/3886) had newly developed type 2 diabetes. For women, compared to the reference first quartile, the HRs for incident type 2 diabetes in the second, third, and fourth platelet count quartiles were 1.20 (0.96–1.50), 1.21(0.97–1.51), and 1.47 (1.18–1.82) after adjusting for age, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, family history of diabetes, and HOMA‐IR. However, these positive relationships were not observed in men after adjusting for the same co‐variables.ConclusionsPlatelet count was independently associated with an increased risk of incident type 2 diabetes only in women.
eDNA metabarcoding from aquatic biofilms allows studying spatial and temporal fluctuations of fish communities from Lake Geneva
Authors: Rivera Sinziana F. , Vasselon Valentin , Bouchez Agnès , Rimet Frédéric 
Published: April 2023

AbstractFish communities are now studied non‐invasively using environmental DNA (eDNA) recovered from water samples. The objective of this study is to evaluate the possibility of surveying these communities using fish eDNA passively “captured” by aquatic biofilms. To this end, biofilm samples developing on natural and artificial substrates were collected every 2 weeks for a year and a half in a large lake (Lake Geneva). DNA was extracted from biofilms and fish communities were targeted using a standard 12S barcode with a metabarcoding approach. The fish eDNA signal recovered from biofilms revealed temporal and spatial changes in fish communities. These changes were linked to fish habitat preferences and spawning season. Peaks in the eDNA signal of some taxa fitted with their spawning period reported in the literature. We evidenced that the nature of the biofilm's substrate (natural or artificial) does not affect the image obtained of the fish community composition. Furthermore, by using biofilms grown on artificial substrates, the studied temporal window of the eDNA signal can be controlled. With biofilms acting as environmental passive samplers, our results open up the possibility to accurately monitor fish communities and their temporal and spatial changes with eDNA in a faster and less expensive way than with the classical water filtration approach.
Tetrathiaporphyrine: A Novel Natural Product from Allium Subgenus Melanocrommyum
Authors: Rüger Fabian , Heine Andreas , Vornicescu Doru , Keusgen Michael 
Published: April 2023

AbstractA novel purple‐red pigment from the plant genus of Allium (onions, leeks), subgenus Melanocrommyum (drumstick onions), is described. Because of this pigment, which reminds of blood, some species of the subgenus Melanocrommyum are used in Southwest and Central Asia as herbal medications, as spices or as vegetables. A proposal for the formation of this structure is provided, which is the first example of a tetrathiaporphyrin in nature. The described substance shows low stability towards thermal stress, light and oxidant; additionally, its symmetric nature made structural elucidation a challenge. It could be shown that, contrary to previous reports, the structure of the red pigment is that of a tetrathiaporphyrin. Full structure elucidation was only possible by X‐ray crystallography and total synthesis of the intended molecule. Further on, the newly discovered red pigment was used for the modification of nanoparticles and monitoring its polymerization events using SPR.
Mycotoxins in milk: Occurrence and evaluation of certain detoxification attempts
Authors: Youssef Nesrine H. , El Gammal Mohamed H. , Altaie Hayman A. A. , Qadhi Alaa , Tufarelli Vincenzo , Losacco Caterina , Abd El‐Hack Mohamed E. , Abdelsalam Nader R. 
Published: April 2023

AbstractMilk contaminated with mycotoxins is a significant issue affecting human health, especially in infants. The current study aimed to investigate the presence of mycotoxins in milk collected from women farmers' vendors (WFV), and to evaluate certain herbal plant fibers as green mycotoxin binders. Moreover, explore the binding efficiency ratios of mycotoxins using shaking or soaking process incorporated with herbal extracts. Furthermore, compare the taste evaluations of tested milk are enriched with herbal extracts. Results indicated that the fumonisins were not detected in the collected cow milk samples but realized a 25% occurrence ratio in buffalo's milk samples. A high occurrence ratio of aflatoxin M1 (aflaM1) was observed in buffalo and cow milk samples. The soaking process of plant fibers in contaminated milk overnight significantly degrades and adsorbs mycotoxins particles. The shacking process incorporated with plant fibers exhibited more effectiveness in mycotoxins degradation than soaking or shacking processes alone. The speed of shacking process played an important role in the mycotoxin's binding process. All the tested plant fibers effectively reduced all mycotoxin presence in contaminated milk, especially green tea, during the soaking or shacking process. Moreover, the shacking process incorporated with plant fibers promoted and supported the mycotoxins degradation process.
Tumor volume as a predictor of survival in advanced laryngeal cancer treated with total laryngectomy
Authors: Hanubal Krishna S. , Galochkina Zhanna , Lee Ji‐Hyun , List Marna A. , Massini Tara C. , Conrad Dustin , Hughley Brian , Danan Deepa , DeJesus Reordan , Hitchcock Kathryn , Nichols Spencer , Mendenhall William , Dziegielewski Peter T. 
Published: April 2023

AbstractBackgroundRecent literature shows that tumor volume (TV) in T3 laryngeal squamous cell carcinoma (LSCC) is associated with response to radiation therapy. The aim of this study was to evaluate the effect of TV on survival outcomes in patients undergoing total laryngectomy (TL).MethodsOne hundred and seventeen patients with LSCC undergoing TL between 2013 and 2020 at the University of Florida were included. TV was measured using a previously validated method on preoperative‐CT scans. Multivariable CoxPH models for overall survival (OS) and disease‐specific survival (DSS), metastasis‐free survival (MFS), and recurrence‐free survival (RFS) were developed with TV.ResultsMean age was 61.5 years and 81.2% were male. Higher TV was associated with decreased OS, MFS, DSS, and RFS with adjusted hazard ratios 1.02 (95%CI: 1.01, 1.03), 1.01, (95%CI: 1.00, 1.03), 1.03 (95%CI: 1.01, 1.06), and 1.02 (95%CI: 1.00, 1.03) respectively. TV >7.1 cc had worse prognoses.ConclusionsTV appears associated with decreased survival in LSCC treated with TL.
Abnormal alanine aminotransferase levels in patients with moderate or severe ovarian hyperstimulation result in an increased risk of obstetric complications
Authors: Qi Tiange , Hu Yueyue , Liu Mei , Tian Liu , Peng Zhiyu , Xu Hongyi , Zhang Changjun 
Published: April 2023

AbstractObjectivesTo explore the effect of abnormally elevated serum alanine aminotransferase (ALT) on pregnancy outcomes in patients with moderate and severe ovarian hyperstimulation syndrome (OHSS) at disease onset.MethodsThis was a single‐center retrospective cohort study conducted between January 1, 2014 and October 31, 2021. A total of 3550 fresh in vitro fertilization/intracytoplasmic sperm injection embryo transfer cycles were included, using Golan's three‐degree, five‐level classification to diagnose patients with OHSS. According to the patient's ALT level after diagnosis of OHSS, 123 (3.46%) patients with moderate‐to‐severe OHSS were divided into two groups. A control group included 3427 (96.54%) non‐OHSS patients, and 91 (2.56%) abnormal ALT patients were matched with the control group for propensity scores.ResultsThere was no difference in baseline data between the abnormal ALT and matched control groups. The incidence of obstetric complications was significantly higher in the abnormal ALT group than in the matched control group (P < 0.05). After adjusting for confounding factors, the incidence of obstetric complications in the abnormal ALT group was still higher than that in the normal ALT group (P < 0.05).ConclusionIn patients with moderate and severe OHSS, higher ALT levels resulted in an increased risk of obstetric and neonatal complications.
Prospective, open‐label, multicenter clinical study to assess the performance of a new donation system for the collection of source plasma
Authors: Mason Emily , Dawson Kati , Rhodes Jack , Kelley James , Meyer Erin Goodhue , Simon Toby L. 
Published: April 2023

AbstractBackgroundSafe, efficient, and reliable innovations among donation systems are needed to meet the growing global demand for source plasma. This study assessed the ability of a new donation system to collect appropriate product weights based on the US Food and Drug Administration nomogram for source plasma collections. Procedure duration and safety endpoints were also collected.Study Design and MethodsThe Rika Plasma Donation System (Terumo BCT, Inc., Lakewood, CO) was evaluated in a prospective, open‐label, multicenter study. Healthy adults meeting FDA and Plasma Protein Therapeutics Association requirements for source plasma donor eligibility were consented and enrolled in the study resulting in 124 evaluable products.ResultsThe target product collection weights (ie, including plasma and anticoagulant) by participant weight category were: 705 g (110–149 lbs), 845 g (150–174 lbs), and 900 g (≥175 lbs). The mean reported product collection weights by participant weight category were 705.0 ± 0.00, 845.0 ± 0.20, and 899.9 ± 0.31 g, respectively. The mean overall procedure time was 31.5 ± 5.41 minutes. The mean procedure times by participant weight category were 25.6 ± 3.13, 30.5 ± 4.45, and 33.7 ± 4.80 minutes, respectively. Procedure‐emergent adverse events (PEAEs) occurred in five participants. All PEAEs were consistent with known risks for apheresis donation, and none were related to the donation system.ConclusionsThe new donation system collected the target product collection weight in 100% of evaluable products. The mean procedure collection time was 31.5 minutes. The system is a new efficient platform that consistently collects the appropriate weight of the source plasma.
Levofloxacin degradation in electro‐Fenton system with Fe@Co/GF composite cathode
Authors: Jia Xiaoning , Li Cailan , Zhao Xia , Xu Miao , Cai Yongjie , Huang Jing , Wu Tong 
Published: April 2023

AbstractBACKGROUNDElements of transition metals have a distinct non‐nuclear electronic structure, and modifying electrodes with transition metals can increase electrocatalytic activity. Due to its low cost and high electrical conductivity, graphite felt (GF) is frequently used as the carbon base material for modified electrodes. GF was treated with KOH and subsequently loaded with the bimetal Fe and Co to create a cathode (Fe@Co/GF) with enhanced catalytic activity in this study.RESULTSUnder optimal experimental conditions (initial levofloxacin (LEV) concentration of 30 mg L−1, electric voltage of 8 V, GF thickness of 3 mm, an aeration rate of 3 4.5 L min−1, Na2SO4 concentration of 0.05 mol L−1, initial Fe2+ concentration of 0.1 mmol L−1, initial pH of 3, KOH activation temperature of 900 °C and Fe@Co ratio of 1:3), the LEV elimination rate was 90.38% and the mineralization rate was 88.53% within 160 min. Compared to the GF cathode, both the total LEV degradation rate and the total mineralization rate increased by approximately 20%. When Fe@Co/GF was used as the cathode in an electro‐Fenton (EF) system without an applied iron source, the Fenton reaction could still occur. In addition, Fe@Co/GF also promoted the degradation of ciprofloxacin in the EF system.CONCLUSIONAccording to morphological and other statistical data, the modified cathode has a larger specific surface area, larger pores and a greater number of active sites. Electrochemical performance measurements indicate that the modified cathode is more responsive to current. Fe@Co/GF cathode was simple to prepare and contributed significantly to the LEV removal process when used as the cathode in an EF system, thereby decreasing the LEV degradation time. © 2023 Society of Chemical Industry (SCI).
Extraction of bioactive compounds in Muntingia calabura peels and identification using DI‐ESI‐MS
Authors: da Silva Luciana Alves , Raimundini Aranha Ana Caroline , Tonin Angélica Priscila Parussolo , de Lima Jéssica Carvalho , Cuco Roberta Pazinato , Filho Lúcio Cardozo , Meurer Eduardo Cesar , Madrona Grasiele Scaramal , da Silva Scapim Mônica Regina 
Published: April 2023

AbstractBackgroundThe purpose of the work reported in this article was to perform the drying of Muntingia calabura peels and to evaluate the performance of supercritical fluid extraction, ultrasound‐assisted extraction and solid–liquid extraction. Four types of extracts were analyzed for mean values of antioxidant activity, phenolic compounds and bioactive compounds in positive and negative modes (0.1% MeOH–NH4OH) using direct injection in electrospray ionization mass spectrometry. Two of the lipid samples, extracted by fluid supercritical CO2, were used for the determination of the profile of triacylglycerols.ResultsRegarding the quantification of compounds, in the extracts SH30 and SH60 were found 18 bioactive compounds; and for the extracts obtained using solid–liquid and ultrasound‐assisted extraction, 12 compounds were found. The triacylglycerols formed by palmitic, oleic and linoleic acids were found with the highest incidence in the lipid samples.ConclusionsFor the quantification of total phenolic compounds and ferric reducing antioxidant power of the four extracts, the results showed a higher retention of the compounds in the samples extracted with supercritical fluid. © 2023 Society of Chemical Industry (SCI).
Assessment of attitudes towards the use of preimplantation genetic diagnosis in a single center in Riyadh, Saudi Arabia
Authors: Alawad Nawaf , Alangari Abdullah , Allhybi Abdulaziz , Masud Nazish , Almuzaini Faisal , Alshamari Mohammed , Umair Muhammad , Alfadhel Majid 
Published: April 2023

AbstractIn this cross‐sectional study, we assessed the attitudes of the general public in Saudi Arabia regarding both medical and non‐medical applications of pre‐implantation genetic diagnosis (PGD). The study was conducted in King Abdullah Specialist Children's Hospital (KASCH) in Riyadh with a sample size of 377. Demographic information was collected, and attitudes towards applications of PGD were assessed using a pre‐validated self‐administered questionnaire. Out of the total sample size, 230 (61%) were males, 258 (68%) were married, 235 (63%) had one child or more, and 255 (68%) were older than 30 years of age representing the majority of participants. Only 87 (23%) of participants reported prior experience with PGD. Personally, knowing someone who had a prior experience with PGD was associated with higher attitude scores (more favorable attitudes towards PGD) (p‐value = 0.04). The findings of this study indicate that our sample of Saudi individuals generally had a positive attitude towards the use of PGD.
Evaluating treatment response following locoregional therapy for hepatocellular carcinoma: A review of the available serological and radiological tools for assessment
Authors: Cox Daniel R A , Chung William , Grace Josephine , Wong Darren , Kutaiba Numan , Ranatunga Dinesh , Khor Richard , Perini Marcos V , Fink Michael , Jones Robert , Goodwin Mark , Dobrovic Alex , Testro Adam , Muralidharan Vijayaragavan 
Published: April 2023

AbstractHepatocellular carcinoma (HCC) is an aggressive primary malignancy of the liver and is the third most common cause of cancer‐related global mortality. There has been a steady increase in treatment options for HCC in recent years, including innovations in both curative and non‐curative therapies. These advances have brought new challenges and necessary improvements in strategies of disease monitoring, to allow early detection of HCC recurrence. Current serological and radiological strategies for post‐treatment monitoring and prognostication and their limitations will be discussed and evaluated in this review.