bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiological etiology in patients with IE undergoing surgery during admission and for patients with medical treatment only: A nationwide study from 2010 to 2020
Authors: Graversen Peter Laursen , Østergaard Lauge , Voldstedlund Marianne , Wandall-Holm Malthe Faurschou , Smerup Morten Holdgaard , Køber Larrs , Fosbøl Emil Loldrup 
Published: June 2023

Abstract

Purpose
Infective endocarditis (IE) is a disease which clinical course and outcomes depend on the underlying microbiological etiology. Microbiological etiology has been associated with surgery during admission – especially Staphylococcus aureus. We aimed to assess patient characteristics, microbiological characteristics, and outcomes by treatment choice.
Methods
We identified patients with first-time IE between 2010–2020 and examined microbiological etiology of IE according to treatment choice (surgery or not). To identify factors associated with surgery we used adjusted logistic regression analysis. One-year mortality stratified by microbiological etiology and treatment choice was assessed by unadjusted Kaplan-Meier estimates and adjusted Cox proportional Hazards model.
Results
A total of 6,255 patients were included, 1276 (20.4%) underwent surgery during admission. Patients who underwent surgery were younger (65 vs. 74 years) and had less comorbidities. Patients with Staphylococcus aureus IE were less likely to undergo surgery during admission (13.6%) compared with all other microbiological etiologies. Streptococcus species (35.0%) was the most frequent microbiological etiology in surgically treated patients compared with Staphylococcus aureus (33.4%) in patients who received medical therapy One-year mortality was examined for groups of microbiological etiology (Staphylococcus aureus, Streptococcus species, Enterococcus species, coagulase-negative Staphylococci, “Other microbiological etiologies” and blood-culture negative). In patients who underwent surgery one-year mortality ranged between 4.9% -13.2% compared to 16,9%-27.5% in patients who received medical therapy. Conclusion: Patients with IE who underwent surgery differed in terms of microbiology, having more often Streptococci than those who received medical therapy. Contrary to expectations, Staphylococcus aureus was more common among patients who received medical therapy only.
The psychosocial determinants of adherence to home-based rehabilitation strategies in parents of children with cerebral palsy: A systematic review
Authors: Niyonsenga Japhet , Bugenimana Athanasie , Musabyemariya Inès , Sagahutu Jean Baptiste , Cavallini Francesca , Caricati Luca , Eugene Rutembesa , Mutabaruka Jean , Jansen Stefan , Monacelli Nadia , Niyonsenga Japhet 
Published: June 2023

Abstract

Background
Involving parents of children with cerebral palsy (C-CP) in home exercise programmes (HEP) is globally practised and closely linked to improved treatment outcomes for physical performance and function. Nevertheless, non-adherence to HEP is increasing at an alarming rate, and little is known about the factors of adherence to HEP (AHEP) especially in parents of C-CP.
Objective
This systematic review was aimed to identify the factors enhancing AHEP among parents of C-CP to reinforce the efficacy of rehabilitation practices proposed by health professionals, researchers, and educators.
Method
We searched PubMed, Scopus, CINHAL, PsycINFO, and Embase for articles published up to March 2023, that investigated the factors of AHEP among parents of C-CP. We conducted a narrative synthesis using the search results and pertinent material from other sources.
Results
Overall non-adherence rates to HEP were moderate to high (34%-79.2%). There was strong evidence that factors enhancing AHEP are in three categories: child-related (low age and gross motor function (GMF), caregiver-related (high self-efficacy and knowledge, high social support, low depression, anxiety and stress symptoms, and low perception of barriers), and the physiotherapist-related. For the last category, parents’ perception of a supportive and collaborative relationship with the therapists is one of the conditions mostly favour AHEP.
Conclusions
Our findings highlight that factors influencing AHEP are multifactorial. Some of them are conditions that are difficult to change such as FGM or the economic and social conditions of the family. Instead, the relationship between therapist and parent is a dimension that can be strengthened. These results suggest the importance of substantial training and psychosocial support for the therapists to make them more aware of and competent in the need to build a supportive relationship with parents.
Study on the prevention and treatment of Aspergillus flavus pollution by Melaleuca alternifolia essential oil during the storage of Polygalae Radix Decoction Pieces
Authors: Xia Wenxin , Lin Lizhen , Yue Jiahui , Li Yuxin , Wang Lulu , Zhang Yuanyuan , Li Tingting , Dong Lin , Fu Xueyan 
Published: June 2023

Abstract
In the natural environment, Aspergillus flavus often causes contamination of food, crop and Chinese medicinal materials, threatening the quality and safety of food, crop and medicinal materials and causing huge economic losses. In this study, we isolated, identified and screened the strains of A. flavus invading polygalae radix, and determined the changes of growth indexes, virulence, antioxidant system and cell membrane integrity of A. flavus under the treatment of Melaleuca alternifolia essential oil (MA-EO). Combined with the results of proteomics, the mechanism of action was clarified. In addition, this study also measured the change of active components in polygalae radix under the action of MA-EO. The results showed that MA-EO could damage cell membrane integrity, increase ROS accumulation, disrupt antioxidant system and inhibit the growth and toxicity of A. flavus. At the same time, MA-EO can significantly reduce the mildew of polygalae radix and curb the loss of active components after mildew.
Recurrent or junctional lumbar foraminal herniated disc in patients operated withtrans pars microscopic approach
Authors: Monticelli Matteo , Gelmi Clarissa Ann Elisabeth , Scerrati Alba , Cavallo Michele Alessandro , De Bonis Pasquale 
Published: June 2023

Abstract
Study design This is a retrospective monocentric studyObjective The aim of this study is to analyze the incidence of recurrent or junctional lumbar foraminal herniated disc, in patients treated with trans pars microsurgical approach.Background Foraminal lumbar disc herniation represents a challenging pathology for the spinal surgeon. The appropriate surgical approach still represents a matter of debate. Several open and minimally-invasive techniques have been developed, in order to allow a proper tissue exposure and preserving the vertebral stability. The trans-pars approach has already been described as a possible alternative, allowing excellent exposure of the herniated fragment with minimum bone removal. While few studies have analyzed the very low rate of post-operative instability, no articles deal with the incidence of post-operative herniated disc recurrence or junctional disc herniation in patients treated with this technique.Methods We enrolled 160 patients operated at our institution.A univariate and multivariate analysis of possible factors influencing outcome (age, sex, level and BMI) was performed. Outcome variables were: recurrent or junctional herniated disc. Results At the end 135 patients were analyzed. Of the 135 patients, six presented recurrent herniated disc (4.4%) and other three developed a junctional herniation (2.2%). The occurrence of junctional herniated disc or recurrent herniated disc were not influenced by the analyzed variables, both at univariate and at multivariate analysesConclusion The trans pars approach presents a low rate of recurrence and junctional herniation. Age, sex, level and BMI do not influence the recurrence rate, both at same level and at junctional level.
Glomerular filtration rate, neurofilament light, and phospho-tau 181 in a community-based cohort: the Shanghai Aging Study
Authors: Wu Jie , Xiao Zhenxu , Wang Mengjing , Wu Wanqing , Ma Xiaoxi , Liang Xiaoniu , Zheng Li , Ding Saineng , Luo Jianfeng , Cao Yang , Hong Zhen , Chen Jing , Zhao Qianhua , Ding Ding 
Published: June 2023

Abstract
Background
The blood-based biomarkers are approaching the clinical practice of Alzheimer’s disease (AD). Chronic kidney disease (CKD) has a potential confounding effect on peripheral protein levels. It is essential to characterize the impact of renal function on AD markers.
Methods
Plasma phospho-tau181 (P-tau181), and neurofilament light (NfL) were assayed via the Simoa HD-X platform in 1189 dementia-free participants from the Shanghai Aging Study (SAS). The estimated glomerular filter rate (eGFR) was calculated. The association between renal function and blood NfL, P-tau181 was analyzed. An analysis of interactions between various demographic and comorbid factors and eGFR was conducted.
Results
The eGFR levels were negatively associated with plasma concentrations of NfL and P-tau181 (B = -0.19, 95%CI -0.224 to -0.156, P < 0.001; B = -0.009, 95%CI -0.013 to -0.005, P < 0.001, respectively). After adjusting for demographic characteristics and comorbid diseases, eGFR remained significantly correlated with plasma NfL (B = -0.010, 95%CI -0.133 to -0.068, P < 0.001), but not with P-tau181 (B = -0.003, 95%CI -0.007 to 0.001, P = 0.194). A significant interaction between age and eGFR was found for plasma NfL (Pinteraction < 0.001). In participants ≥ 70 years and with eGFR < 60 ml/min/1.73 m2, the correlation between eGFR and plasma NfL was significantly remarkable (B = -0.790, 95%CI -1.026 to -0,554, P < 0.001).
Conclusions
Considering renal function and age is crucial when interpreting AD biomarkers in the general aging population.
Numerical Study and Experimental Validation of Copper Powder Plasma Spheroidization Process
Authors: Sehhat M. Hossein , Leu Ming C. 
Published: June 2023

Abstract
As the extensive research in Additive Manufacturing (AM) shows, the powder characteristics, such as particle size and geometry, play an important role in determining the quality of powder layer and part fabricated with powder-based AM processes. It has been found that spherical particles result in better powder flowability and spreadability. An attempt to improve particle sphericity is to process the powder using the plasma spheroidization process, where the particles heat up, melt, and reshape to spheres. Several research works have been conducted to study the plasma spheroidization process and understand particle-plasma reactions. Although researchers have turned to simulations to overcome the difficulty of experimental study of such reactions, they only sufficed to characterize the powder particle size without evaluating the particle geometries. In this work, the plasma spheroidization process of copper powder was numerically examined to assess the impact of plasma spheroidization process on powder geometry and particle size. For the first time in literature, a method was proposed to quantify the particle geometry at each particle residence time. The results of simulation matched well with those of experiments.
Sequence characteristics and expression analysis of CYP17A1 and CYP17A2 genes in Chlamys farreri
Authors: Liu Xiaoling , Yun Han , Mu Xuejiao 
Published: June 2023

Abstract
CYP17A1 and CYP17A2 genes are members of the CYP17 subfamily and belong to the P450 superfamily. This study analyzed the sequences of Chlamys farreri (C. farreri) CYP17A1 and CYP17A2, found that the CYP17A1 coding sequence (CDS) is 1287 bp, encoding 428 amino acids, and the CYP17A2 coding sequence is 1512 bp, encoding 503 amino acids. The two genes both contain three conserved regions: the Ozols' tripeptide region, the heme binding region, and the Ono sequence which is unique to CYP17 subfamily, and these regions are conserved in different species by the homology analysis of multiple amino sequence. Semi-quantitative RT-PCR (SqRT-PCR) showed that CYP17A1 was strongly expressed in the kidney and hepatopancreas of females, strongly expressed in the hepatopancreas of males, and weakly expressed in other tissues. CYP17A2 was strongly expressed in the kidney and gill of females, in the adductor muscle, kidney, gill and testis of males, weakly expressed in other tissues. The wide expression of CYP17A1 and CYP17A2 in C. farreri suggest that they may play multiple roles in different tissues.Using real-time fluorescent quantitative PCR (qPCR), the expression during gametogenesis was detected, CYP17A1 was expressed highest at the ovarian growth stage., it was considered the gene may play a role in oocytes growth, furthermore, we speculated that the gene may affect oocyte growth by participating in production of estradiol. CYP17A1 expression increased with the testis development, which implied this gene may be involved in the testosterone’ production. CYP17A2 expressed highest in testis at mature stage, it was believed that this gene may affect sperm excretion and motility by participating in pregnancy hormones production. CYP17A2 expressed higher in the ovary at mature stage than other stages, it is speculated that this gene may play a role in oocytes maturation by participating in 17α, 20β-DP (17α, 20β-dihydroxy-4-pregnen-3-one, DHP, a kind of progesterone) production.
Unlocking the Potential of VANETs: Trust-Based Authentication and Deep Learning for Enhanced Security and Efficiency
Authors: Thirumalaisamy Manikandan , George Michael , Uthirapathy Arul , Rajaram Gnanajeyaraman , Alagappan Selvakumar , Sundar Ramesh 
Published: June 2023

Abstract
Vehicular Adhoc Networks (VANETs) are emerging as a crucial component in the development of Intelligent Transportation Systems (ITS). These networks aim to enhance traffic operations, increase safety, and facilitate communication between vehicles and infrastructure. However, VANETs face significant privacy and security challenges. This study proposes a novel approach to address VANET energy efficiency and privacy analysis using a trust-based authentication system and deep learning methods. Attention layer integrated gradient kernel vector flow neural networks are utilized for classifying monitored data to detect malicious users. The hybrid multipath energy-efficient routing protocol contributes to improved energy efficiency. The experimental analysis evaluates energy efficiency, latency, throughput, packet delivery ratio, computational cost, and communication overhead, and trust value analysis. The proposed technique achieved energy efficiency of 99%, latency of 63%, throughput of 95%, PDR of 88%, computational cost of 57%, communication overhead of 59%, and trust value analysis of 77%. The experimental analysis reveals promising results in various performance metrics, demonstrating the potential of this approach in ensuring passenger and driver safety while addressing communication and security challenges in VANETs.
Exposure to OPFRs is associated with obesity and dysregulated serum lipid profiles: data from 2017-2018 NHANES
Authors: Xing Weilong , Liang Mengyuan , Gu Wen , Wang Zhen , Fan Deling , Zhang Bing , Sun Shuai , Wang Lei , Shi Lili 
Published: June 2023

Abstract
Background
Exposure to organophosphate flame retardant (OPFRs) is widespread in general population. Emerging studies revealed OPFRs have endocrine disturbing property. However, research investigating OPFRs exposure, obesity and serum lipid profiles is limited. We aim to evaluate the association between urinary metabolites of OPFRs, BMI, and serum lipid profiles.
Methods
Data from National Health and Nutrition Examination Survey (NHANES) 2017–2018 was obtained. 1334 adults were enrolled in the current study. Urinary concentrations of bis (1-chloro-2-propyl) phosphate (BCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), dibutyl phosphate (DBUP), and diphenyl phosphate (DPHP) were quantified to assess OPFRs exposure. Covariate-adjusted linear and logistic regression models were conducted to explore the associations between log2-transformed concentrations of OPFRs metabolites, BMI, obesity and serum lipid profiles. Stratified analyses were performed to assess the heterogeneity of associations by age, gender, race, etc.
Results
Increased urinary concentrations of BCEP and BDCPP were positively associated with 0.27 (95% CI: 0.02–0.52, p = 0.0338) and 0.56 (95% CI: 0.25–0.87, p = 0.0004) higher BMI value, respectively. One log2-unit increase in urinary BCEP concentrations was associated with 10% higher risk for developing obesity (95% CI: 1.02–1.18, p = 0.0096). Additionally, one log2-unit increase in BDCPP was associated with 19% higher risk for obesity (95% CI: 1.09–1.30, p = 0.0001). Multivariable linear regression showed urinary DPHP concentrations were inversely correlated with serum TG levels (β=-7.41, 95% CI: -12.13 to -2.68, p = 0.0022).
Conclusion
Environmental exposure to OPFRs might contribute to obesity and dysregulated serum lipid in adults. Future prospective researches are warranted to confirm the causal relationship between metabolites of OPFRs and obesity.
Hotspots and Frontiers of Atrial Fibrillation and Cognitive Dysfunction: a bibliometric and visual analysis
Authors: Huang Hengyi , Wang Qing , Jia Ruirui , Chung Yuet Foon , Liang Tao , Qiu Yuran 
Published: June 2023

AbstractBackground:Atrial fibrillation is a supraventricular tachyarrhythmia with uncoordinated atrial electrical activation and ineffective atrial contraction. Cognitive dysfunction is a syndrome of impaired cognitive function due to abnormalities in brain structure or function, mainly including mild cognitive impairment and dementia. Numerous studies have shown that the two are closely related. In recent years, many advances have been made in this field, but few studies have systematically combed, analyzed and summarized the current research status in this field. This study aimed to analyze existing studies on atrial fibrillation and cognitive dysfunction using bibliometrics.Methods:Relevant articles and reviews on cognitive dysfunction and atrial fibrillation were retrieved from the Web of Science Core Collection. Bibliometric analysis was performed in Excel16.70, VOSviewer 1.6.18, CiteSpace 6.1.6 and R 4.2.1.Results:A total of 1531 articles and reviews from establishing the database to 2023 were included in the bibliometric analysis. The earliest related research appeared in 1985, and the research in this field officially started after 1997 and entered the stage of rapid development in 2012. European and American countries started earlier in this field of research. There is a particular gap among regions, and different countries and institutions must actively strengthen cooperation. The United States had the most significant number of publications. Stroke was the most influential journal, and Lip GYH was the authoritative author in the field.The research focused on the mechanism of atrial fibrillation and cognitive dysfunction, anticoagulation, radiofrequency ablation, and epidemiology.Conclusion:In the past decade, research in this field has entered a stage of rapid development. The United States was clearly leading, and different countries and institutions need to strengthen cooperation actively. The mechanism, methods of diagnosis and treatment, and epidemiology of atrial fibrillation and cognitive dysfunction will remain the focus of research in the future, and early prevention and intervention are of great significance.
Prognostic model for oversurvival and tumor-specific survival prediction in patients with advanced extrahepatic cholangiocarcinoma: a population-based analysis
Authors: Zhang Yu , Zhang Changhe 
Published: June 2023

Abstract
Background
The prognosis of patients with extrahepatic cholangiocarcinoma (ECCA) must be determined with precision. However, the usual TNM staging system has the drawback of ignoring sex, adjuvant therapy, and gender and lacks the ability to more correctly predict patient prognosis. Therefore, it is essential to establish a thorough examination of nomograms that takes into account each potential factor. The nomogram enables clinicians to offer individualized treatment strategies and make more precise prognosis predictions. As a result, we determine the risk factors of survival for patients with advanced ECCA patients and developed brand-new nomograms to forecast patients with advanced ECCA's overall survival (OS) and cancer-specific survival (CSS).
Method
From the Epidemiology and End Results (SEER) database, patients with advanced ECCA were chosen and randomly assigned in a ratio of 6:4 to the training and validation subgroups. The cumulative incidence function (CIF) difference between groups was confirmed by applying Gray's and Fine test and competing risk analyses. Next, the cancer-specific survival (CSS) and overall survival (OS) nomograms for advanced ECCA were developed and validated..
Results
In accordance with the selection criteria, 403 patients with advanced ECCA were acquired from the SEER database and then split at random into two groups: a training group (n = 241) and a validation group (n = 162). The 1-, 2-, and 3-year cancer-specific mortality rates were 58.7%, 74.2%, and 78.0%, respectively, while the matching mortality rates for the competition were 10.0%, 13.8%, and 15.0%. Nomograms were generated for estimating OS and CSS, and they were assessed using the ROC curve and the C-index. The calibration curves showed that there was a fair amount of agreement between the expected and actual probabilities of OS and CSS. Additionally, greater areas under the ROC curve were seen in the newly developed nomograms for OS and CSS when compared to the previous 7th AJCC staging system. The advanced ECCA patients were divided into groupings with an elevated risk and those with a low risk based on their total score after the addition of the nomogram-based criteria. The Kaplan-Meier method was used for the survival analysis, which showed that survival time was shorter in the high-risk group than in the low-risk group. Since the nomograms had strong validation, they might help clinical practice and improve patient outcomes.
Conclusion
The proposed nomograms have good predictive ability. The nomograms may can help doctors determine the prognosis of patients with advanced ECCA as well as provide more precise treatment plans for them.