bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congestion Control Scheme for Link Quality Improvement Using Bio‐Inspired Fuzzy Inference System–Based CoAP in IoT
Authors: Yadav Raveena , Kumar Vinod 
Published: January 2025

ABSTRACTThe Internet of Things (IoT) represents the Internet's future by including devices that can connect with one another. IoT devices in IoT networks collect data from their surroundings and send it in bursts to a server in a remote location. The quantity of applications using computer networks causes resource competition, which in turn causes congestion. The most difficult task in enhancing network quality of service (QoS) is IoT congestion control. For IoT items with modest resource requirements, various protocols have arisen. Different shortages and issues affect basic congestion control, which increases bandwidth use, data loss, and delay. Thus, to solve this issue, in this paper, we propose a bio‐inspired fuzzy inference system (FIS)–based constrained application protocol (BIFIS‐CoAP) for avoiding congestion over network. In order to determine the level of congestion, we use the bottleneck bandwidth gradient (BG‐gradient) and round‐trip time gradient (RT‐gradient) as inputs for BIFIS‐CoAP. By using this indication, BIFIS‐CoAP may anticipate impending congestion and alter the sending rate to prevent it. In order to achieve high performance for burst data transfer, BIFIS‐CoAP constantly checks for bandwidth that is available and uses the congestion degree for updating the variable retransmission time out (RTO) for retransmissions. Using the adaptive Tasmanian devil optimization method (ATDO), input parameters like the RT‐gradient and BG‐gradient are modified to enhance the performance of the FIS. Numerous simulation studies have shown that BIFIS‐CoAP is feasible, and the simulation results show that it performs better than basic CoAP and fuzzy CoAP in terms of delay, throughput, delivery ratio, and retransmissions.
Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health
Authors: Milligan Armstrong Ayeisha , O'Brien Eleanor , Porter Tenielle , Dore Vincent , Bourgeat Pierrick , Maruff Paul , Rowe Christopher C. , Villemagne Victor. L. , Rainey‐Smith Stephanie R. , Laws Simon M. ,   the AIBL Research Group
Published: January 2025

AbstractINTRODUCTIONMelanopsin is a photopigment with roles in mediating sleep and circadian‐related processes, which are often disrupted in Alzheimer's disease (AD). Melanopsin also impacts cognition and synaptogenesis. This study investigated the associations between melanopsin genetic variants, sleep, and markers of brain health.METHODSLinear regression analyses examined the relationship of single‐nucleotide polymorphisms (SNPs) within the melanopsin gene (OPN4), with cortical amyloid beta (Aβ), cognition, brain volumes, and self‐reported sleep traits in cognitively unimpaired older adults. Further analyses assessed whether sleep traits x OPN4 SNP interactions were associated with markers of brain health.RESULTSOPN4 SNPs rs2355009 and rs3740334 were associated with attention and processing speed and ventricular volume and language, respectively. Furthermore, rs3740334 and rs1079610 showed significant interactions with sleep traits in association with language.DISCUSSIONThis study shows associations of OPN4 genetic variants with markers of brain health, and suggests that these variants interact with sleep to exacerbate cognitive effects.Highlights
The relationships between melanopsin gene (OPN4) variants and markers of brain health were examined cross‐sectionally in cognitively unimpaired older individuals.
Variation within OPN4is associated with differences in cognition and ventricular volume.
rs2355009 and rs3740334 show small–moderate associations with differences in attention and processing speed. Further to this, rs2355009 and rs3740334 were associated with ventricular volumes and language performance, respectively.
The interactions between rs3740334 and rs1079610 and sleep traits also showed small–moderate associations with differences in language performance.
Incidence of dementia in the German Heinz Nixdorf Recall study over 20 years
Authors: Schramm Sara , Rinck Charlotte , Krizanovic Nela , Jöckel Karl‐Heinz , Hüsing Anika , Gronewold Janine , Hermann Dirk , Schmidt Börge , Stang Andreas , Jokisch Martha 
Published: January 2025

AbstractINTRODUCTIONThe aim of the study was to estimate the population‐based dementia incidence in Germany over a period of two decades.METHODSWe analyzed data from 4814 participants of the population‐based Heinz Nixdorf Recall study (49.8% men, 45–75 years at baseline period 2000–2003), who have been monitored for the occurrence of cognitive decline and dementia. We calculated the cumulative incidence of dementia and its major subtypes and the incidence rate per 1000 person‐years over two decades.RESULTSDuring a median follow‐up of 18.2 (Q1–Q3: 11.3–20.6) years, a total of 298 participants (6.2%) developed dementia (22.1% Alzheimer´s disease, 23.5% vascular dementia, 15.1% mixed dementia, 9.1% other dementia, 30.2% unspecified). The overall incidence rate was 3.9 per 1000 person‐years.DISCUSSIONOur study is the only current population‐based study in Germany that estimates the incidence of dementia. In order to reduce the high proportion of unspecific dementia diagnoses, diagnostics urgently need to be improved.Highlights
New data on the incidence of dementia in Germany in participants ≥45 years of age.
Participants have been monitored for dementia incidence over two decades.
The overall incidence in our cohort was 3.9 per 1000 person‐years.
Many patients had unspecific dementia diagnoses in their medical records.
Further diagnostic evaluation should be available for all dementia patients.
Comparison of Demographic Life‐History Traits of the Snake‐Eyed Skink: Observations From an Island and a Mainland Population
Authors: Ağdağ Mehtap , Yıldız Mehmet Zülfü , Altunışık Abdullah 
Published: January 2025

ABSTRACTThe life‐history traits of animals are influenced by several factors. It has been proposed that key factors such as competition, predation pressure, and resource availability may differ between mainland and island populations of the same species. In this context, our study focused on an island (Yayla, Cyprus) and mainland (Hassa, Türkiye) populations of the snake‐eyed skink, Ablepharus budaki. This study aimed to reveal both intra‐population and inter‐population relationships in terms of mean age, longevity, age at maturity, body size, and sexual dimorphism. Our results show that lizards in the island population had longer lifespans and higher mean ages than the mainland population. Nevertheless, both populations were comparable in terms of mean body size. We also concluded that island individuals reach sexual maturity approximately 1 year later than their mainland conspecifics, and sexual dimorphism in terms of size is observed only in the mainland population. This study, offering initial demographic insights into the non‐mainland population of the species, provides the reason for additional research in this field.
Reliability Assessment of an Improved Single‐Input Switched‐Capacitor Boost 7/9‐Level Inverter Suitable for Renewable Energies
Authors: Ghelichi Armin , Varesi Kazem , Khoubrooy Eslamloo Milad 
Published: January 2025

ABSTRACTThis paper proposes an improved single‐source switched‐capacitor inverter that can operate either as 7 or 9‐level inverter based on its capacitors' charging scenario. The proposed inverter utilizes single DC supply, two capacitors, ten switches (all unidirectional) and a single diode to provide a triple/quadruple boosting factor in its seven/nine‐level operation mode. In 7‐level (7 L) operation mode, both the capacitors are charged to identical voltage value (equal to the source voltage), but in 9‐level (9 L) mode, the capacitors are charged to different voltages. Any load type with variety of power factors can be supplied by the proposed inverter. The capacitors' impulsive charging current issue has been solved by employing compact (small‐inductor based) and low‐cost soft‐charging L‐D cells. The reliability assessments have also been performed on the proposed 7/9‐level inverter. The superiority of the proposed inverter over its similar counterparts have been verified by comprehensive comparative analysis. The experimental outcomes have also been provided to make sure of correct performance of proposed inverter.
Low‐Carbon Dispatch of Integrated Energy Systems Considering Solar Thermal Coupled Combined Heat and Power Units
Authors: Lv You , Li Zeyang , Deng Dan , Shi Yijun , Sun Hao , Wang Tenghui 
Published: January 2025

ABSTRACTTo reduce carbon emissions of an integrated energy system (IES), and decrease curtailment of wind and solar energy due to the “power determined by heat” characteristics of combined heat and power (CHP) units, this paper proposes a low‐carbon and economic optimal scheduling model of an IES that considers solar thermal coupled with CHP. First, to alleviate the coupling of heat and electric power, a solar thermal collector (STC)‐CHP unit model is developed by integrating an STC unit with the traditional CHP unit in the IES. In addition, hydrogen energy utilization equipment, including hydrogen fuel cell (HFC), hydrogen storage (HS), is introduced based on the traditional power‐to‐gas (P2G) process, to fully exploit the value of hydrogen. Meanwhile, the carbon capture system (CCS) is considered in the IES to reduce the carbon emission. Next, a low‐carbon economic dispatch model of the STC‐CHP‐P2G‐CCS coupled IES is established considering the reward and punishment ladder‐type carbon trading (RPLCT) mechanism, aiming to minimize economic costs. The proposed model is solved by programming the CPLEX solver through the YALMIP toolbox. Finally, two categories of scenarios simulation are set up to evaluate the proposed IES and its dispatch strategy. Results show that the total daily operating cost of the proposed system amounts to 8.6525 million RMB, marking a significant reduction of 8.2695 million RMB compared to the basic system. This substantial saving not only covers but also exceeds the daily investment cost of 1.8561 million RMB required for the new equipment, demonstrating a certain level of economic viability. In addition, the system achieves a 100% renewable energy accommodation rate, and carbon emissions are reduced by 2596.3 tons by incorporating the RPLCT mechanism, achieving negative carbon emissions.
Achieving National Food Security in Sub‐Saharan African Countries: The Role of Foreign Agricultural Aid
Authors: Balcilar Mehmet , Olasehinde‐Williams Godwin , Tokar Berkan 
Published: January 2025

ABSTRACTAfrican policymakers have astutely prioritized agricultural expenditure as a crucial strategy to address food insecurity in the continent. However, the available financial resources are insufficient to achieve this objective. Foreign agricultural aid has been proposed as a viable supplement to domestic resource mobilization efforts in bridging the resource deficit. This article investigates the food security implications of sector‐specific aid (agricultural aid) between 1990 and 2020, thus broadening the current understanding. By considering the heterogeneous nature of SSA, this study delves deeper into the relationship between foreign agricultural aid and food security in the region. It investigates both panel and country‐specific causal relationships, providing a more nuanced understanding of the subject. Quantile panel‐type regressions are employed. Coefficients from the fixed effects and random effects with Driscoll–Kraay standard errors are also reported. Additionally, causal linkages between foreign agricultural aid and food security are examined through panel causality testing with bootstrapping. Findings show that agricultural aid contributes to closing the resource gap and improving food security. Also, the effectiveness of agricultural aid is greater when food security is relatively poor, and its impact diminishes as food security improves. Causal relationships suggest that agricultural aid is a determinant of food security. The level of food security is also an indicator of agricultural aid inflows. Thus, strategies such as population control, poverty reduction, and increased access to agricultural land can enhance food security.
Housing Relocation and Residential Satisfaction After Relocation: Effects of Dwelling Condition Changes on Older Adults in the Community
Authors: Park Gum‐Ryeong , Seo Bo Kyong , Namkung Eun Ha 
Published: January 2025

ABSTRACTBackgroundThis study seeks to analyze the trajectories of residential satisfaction among older adults before and after relocation and explore the variability in the relationship between relocation and residential satisfaction based on changes in housing conditions during the relocation process.MethodsUtilizing a nationally representative longitudinal dataset of older adults (N = 2718), this study employs individual‐level fixed effect regression models to estimate the association between the timing of relocation and residential satisfaction. Stratified analyses are also conducted to explore how this association varies based on changes in housing conditions.ResultsResidential satisfaction tends to decrease before relocation, peaks at the time of relocation, and maintain higher levels as older adults adapt to their new environment. This adaptation process varies depending on changes in dwelling conditions during relocation, with transitions from poor to non‐poor housing conditions positively affecting psychological responses, while moves from non‐poor to poor conditions can lead to increased psychological burden and prolonged adjustment periods.DiscussionAging policies can prioritize programs that facilitate adjustment to new environments to improve residential satisfaction of older adults, thereby promoting healthy aging.
Idecabtagene vicleucel or ciltacabtagene autoleucel for relapsed or refractory multiple myeloma: An international multicenter study
Authors: Merz Maximilian , Albici Anca‐Maria , von Tresckow Bastian , Rathje Kristin , Fenk Roland , Holderried Tobias , Müller Fabian , Tovar Natalia , Oliver‐Cáldes Aina , Vucinic Vladan , Kharboutli Soraya , Bärmann Ben‐Niklas , Ayuk Francis , Platzbecker Uwe , Stölzel Friedrich , Schub Nathalie , Schmitz Friederike , Fandrei David , Born Patrick , Khandanpour Cyrus , Hanoun Christine , Hörster Keven , Teichert Marcel , Jeker Barbara , Hoffmann Michele , Kröger Nicolaus , de Larrea Carlos Fernández , Pabst Thomas , Gagelmann Nico 
Published: January 2025

AbstractIdecabtagene vicleucel (ide‐cel) and ciltacabtagene autoleucel (cilta‐cel) have revolutionized the treatment of relapsed/refractory multiple myeloma (RRMM), but direct comparisons are lacking. Leveraging an international multicenter RRMM cohort, we compared the outcome of ide‐cel (n = 162) versus cilta‐cel (n = 42). Co‐primary efficacy endpoints of the study were overall response rate (ORR) and progression‐free survival (PFS). Co‐primary safety endpoints were the incidence of cytokine release syndrome (CRS) and immune‐effector cell‐associated neurotoxicity syndrome (ICANS). Median turnaround time between apheresis and infusion was 47 days for ide‐cel versus 68 days for cilta‐cel (p < 0.001). Cilta‐cel showed significantly higher ORR (93% vs. 79%; p < 0.001), with complete response at Day 30 of 48% versus 26% (p < 0.001). The 10‐month PFS and overall survival (OS) was 82% and 90% for cilta‐cel versus 47% and 77% ide‐cel (p < 0.001 and p = 0.06), and improved outcome for cilta‐cel was confirmed after multivariable adjustment. Incidence of CRS and ICANS appeared similar (81% and 19% for cilta‐cel versus 85% and 19% for ide‐cel), while 10% and 7% in the cilta‐cel group versus 4% and 2% in the ide‐cel group showed severe CRS and ICANS grade 3–4, with CRS occurring significantly earlier for ide‐cel (median, 2 days vs. 4 days; p < 0.001). Nonrelapse mortality was 5% for cilta‐cel versus 3% for ide‐cel (p = 0.51). Cilta‐cel showed later peak of CAR‐T expansion at Day 14 versus Day 7 for ide‐cel, while cilta‐cel expansion was associated with ICANS. Our study provides real‐world evidence that cilta‐cel was associated with superior outcomes and distinct cellular dynamics versus ide‐cel in triple‐class exposed RRMM.
Identification of SETD4 as an Onco‐Immunological Biomarker Encompassing the Tumor Microenvironment, Prognoses, and Therapeutic Responses in Various Human Cancers
Authors: Zhong Yuyun , Wang Ruiqi , Huang Zijie , Hu Zhaoting , Peng Bin , Chen Bin , Sun Liyue 
Published: January 2025

ABSTRACTBackgroundSET domain‐containing protein 4 (SETD4) is a histone methyltransferase that has been shown to modulate cell proliferation, differentiation, and inflammatory responses by regulating histone H4 trimethylation (H4K20me3). Previous reports have demonstrated its function in the quiescence of cancer stem cells as well as drug resistance in several cancers. A limited number of systematic studies have examined SETD4's role in the tumor microenvironment, pathogenesis, prognosis, and therapeutic response.MethodsUtilizing The Cancer Genome Atlas database, and other publicly accessible platforms, we comprehensively analyzed SETD4 gene expression, methylation patterns, and prognostic significance. Furthermore, we investigated its association with cancer‐related pathways, the immune microenvironment, immunotherapy markers, and drug resistance signatures of chemotherapy. Additionally, qRT‐PCR was performed to validate SETD4 expression in clinical specimens.ResultsThe expression of SETD4 was abnormal across a variety of cancer types and the expression of SETD4 in colorectal cancer tissues was verified in clinical specimens. The upregulation of SETD4 may be a prognostic risk factor predicting poor overall survival and progression‐free survival. The analysis revealed that the mRNA level of SETD4 was modulated by promoter methylation, and patients with lower methylation levels showed shorter survival times. Pathway analysis showed that SETD4 influenced several key cell cycle pathways, including the G2M checkpoint, and mitotic spindle pathways. In addition, SETD4 negatively affects immune cell infiltration in most cancers, including B cells, CD8 T cells, and macrophages. The correlation between SETD4 and cancer stemness as well as homologous recombination deficiency varied across tumor types, suggesting that SETD4 may play a multifaceted role in tumor resistance. Notably, we identified several potential agents targeting SETD4.ConclusionsThis study demonstrates that SETD4 is an immune‐oncogenic molecule in multiple cancers, with the potential to be a diagnosis, prognosis, and targeted therapy marker.
Tinagl1 restores tamoxifen sensitivity and blocks fibronectin‐induced EMT by simultaneously blocking the EGFR and β1‐integrin/FAK signaling pathways in tamoxifen‐resistant breast cancer cells
Authors: Yuan Jie , Yuan Li , Yang Li , Chinnathambi Arunachalam , Alharbi Sulaiman Ali , Huang Jun , Wang Bei , Zhang Shuqi , Wei Changsheng , Luo Chengyu 
Published: January 2025

AbstractTamoxifen (TAM) is employed to treat premenopausal ER‐positive breast cancer patients, but TAM resistance is the main reason affecting its efficacy. Thus, addressing TAM resistance is crucial for improving therapeutic outcomes. This study explored the potential role of Tinagl1, a secreted extracellular matrix protein, whose expression is compromised in TAM‐resistant MCF‐7 breast cancer cells (MCF‐7R). We discovered that Tinagl1 plays a pivotal role in countering TAM resistance by inhibiting the EGFR and β1‐integrin/focal adhesion kinase (FAK) signaling pathways, both of which are abnormally activated in MCF‐7R cells and contribute to the resistance mechanism. Our data showed that the expression level of Tinagl1 in MCF‐7R cells was lower compared to their wild‐type counterparts, and TAM could further reduce Tinagl1 expression in MCF‐7R cells, which was consistent with our microarray results. Moreover, Tinagl1 could restore the sensitivity of MCF‐7R cells to TAM and inhibit the motility of MCF‐7R cells by regulating epithelial‐mesenchymal transition (EMT) in vitro and in vivo experiments. In addition, the level of Tinagl1 in TAM‐resistant breast cancer samples was significantly lower than that in their matched primary tumors. Analysis of an online database further indicated that high Tinagl1 expression correlates with better recurrence‐free survival (RFS), particularly in patients with ER‐positive, HER2‐negative breast cancer. Overall, this study positions Tinagl1 not only as a potential prognostic marker but also as a promising therapeutic target.
Deciphering the Role of Calcium Signaling Pathway‐Associated Single Nucleotide Variants in Susceptibility to Hypertension
Authors: Sharifi Armin , Azimi Azam , Alibakhshi Reza , Rahimi Zohreh , Jalilian Nazanin 
Published: January 2025

ABSTRACTBackgroundAs a complex disease, hypertension (HTN) is influenced by both genetic and environmental factors and their interaction. The calcium signaling pathway is known to be involved in the regulation of blood pressure, and dysfunction in this pathway may contribute to the development of hypertension. Genome‐wide association studies (GWAS) have identified several genes in the calcium signaling pathway associated with susceptibility to HTN, including PLCB1, ATP2B1, and ADRB1. The aim of this study was to investigate the possible association between single nucleotide variants (SNVs) in the calcium signaling pathway and HTN.MethodsWe genotyped three SNVs: rs1801253 (ADRB1), rs6108168 (PLCB1), and rs17249754 (ATP2B1) in a population of 131 patients with hypertension and 115 healthy controls from Kermanshah province, Iran.ResultsOur results showed a strong and significant association between the G allele and the GG and CG genotypes of the rs1801253 variant in the ADRB1 gene and susceptibility to hypertension. However, no significant association was found for the other two SNVs. In addition, the presence of the GCG haplotype (alleles from left to right: rs1801253, rs6108168, and rs17249754) appeared to confer a protective role against HTN.ConclusionThis study has made a significant contribution towards enhancing the comprehension of hypertension development, as well as the early identification of individuals who are at risk.