bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic and physiological comparison of Shatangju (Citrus reticulata) and its late-maturing mutant provides insights into auxin regulation of citrus fruit maturation
Authors: Lv Yuanda , Ren Shuang , Wu Bo , Jiang Caizhong , Jiang Bo , Zhou Birong , Zhong Guangyan , Zhong Yun , Yan Huaxue 
Published: July 2023

Abstract
Previous studies have shown that abscisic acid (ABA) and ethylene are involved in pulp maturation and peel coloration in the nonclimacteric citrus fruits. There are also signs indicating that other plant hormones may play some roles in citrus fruit ripening. In this study, we compared profiles of genome-wide gene expression and changes in hormones and peel pigments between fruits of Shatangju mandarin (Citrus reticulata Blanco, designated WT) and its natural mutant, Yuenongwanju (designated MT). The MT fruit matures ~2 months later than the WT fruit. Significant differences in fruit diameter, total soluble solids, titratable acid content, chlorophylls and carotenoids were detected between the fruits of the two genotypes at the sampled time points. Genome-wide transcriptome profiling showed that many genes involved in auxin and ABA metabolism and/or signaling pathways were differentially expressed between the MT and the WT fruits. Importantly, the expression of CrYUCCA8 was significantly lower and the expression of CrNCED5 was significantly higher in WT than in MT fruits at 230 and 250 DPA, respectively. In addition, the indole-3-acetic acid (IAA) level in the MT fruit was significantly higher than that in the WT counterpart, whereas a significantly lower level of ABA was detected in the mutant. Treatment of the WT fruit with exogenous IAA significantly delayed fruit maturation. Our results provide experimental evidence supporting the notion that auxin is a negative regulator of fruit maturation in citrus.
SIRT6: A potential therapeutic target for diabetic cardiomyopathy
Authors: Wu Tao , Qu Yiwei , Xu Shengjie , Wang Yong , Liu Xue , Ma Dufang 
Published: July 2023

AbstractThe abnormal lipid metabolism in diabetic cardiomyopathy can cause myocardial mitochondrial dysfunction, lipotoxicity, abnormal death of myocardial cells, and myocardial remodeling. Mitochondrial homeostasis and normal lipid metabolism can effectively slow down the development of diabetic cardiomyopathy. Recent studies have shown that SIRT6 may play an important role in the pathological changes of diabetic cardiomyopathy such as myocardial cell death, myocardial hypertrophy, and myocardial fibrosis by regulating mitochondrial oxidative stress and glucose and lipid metabolism. Therefore, understanding the function of SIRT6 and its role in the pathogenesis of diabetic cardiomyopathy is of great significance for exploring and developing new targets and drugs for the treatment of diabetic cardiomyopathy. This article reviews the latest findings of SIRT6 in the pathogenesis of diabetic cardiomyopathy, focusing on the regulation of mitochondria and lipid metabolism by SIRT6 to explore potential clinical treatments.
rvTWAS: identifying gene-trait association using sequences by utilizing transcriptome-directed feature selection
Authors: He Jingni , Li Qing , Zhang Qingrun 
Published: July 2023

ABSTRACTTowards the identification of genetic basis of complex traits, transcriptome-wide association study (TWAS) is successful in integrating transcriptome data. However, TWAS is only applicable for common variants, excluding rare variants in exome or whole genome sequences. This is partly because of the inherent limitation of TWAS protocols that rely on predicting gene expressions. Briefly, a typical TWAS protocol has two steps: it trains an expression prediction model in a reference dataset containing gene expressions and genotype, and then applies this prediction model to a genotype-phenotype dataset to “impute” the unobserved expression (that is called GReX) to be associated to the phenotype. In this procedure, rare variants are not used due to its low power in predicting expressions. Our previous research has revealed the insight into TWAS: the two steps are essentially genetic feature selection and aggregations that do not have to involve predictions. Based on this insight disentangling TWAS, rare variants’ inability of predicting expression traits is no longer an obstacle. Herein, we developed “rare variant TWAS”, or rvTWAS, that first uses a Bayesian model to conduct expression-directed feature selection and then use a kernel machine to carry out feature aggregation, forming a model leveraging expressions for association mapping including rare variants. We demonstrated the performance of rvTWAS by thorough simulations and real data analysis in three psychiatric disorders, namely schizophrenia, bipolar disorder, and autism spectrum disorder. rvTWAS will open a door for sequence-based association mappings integrating gene expressions.
Safety and immunogenicity of a heterologous booster with an RBD virus-like particle vaccine following two- or three-dose inactivated COVID-19 vaccine
Authors: Yong Xiaolan , Liu Jun , Zeng Ying , Nie Jing , Cui Xuelian , Wang Tao , Wang Yilin , Chen Yiyong , Kang Wei , Yang Zhonghua , Liu Yan 
Published: July 2023

AbstractBackgroundReduced protection against COVID-19 due to the waning vaccine-induced immunity over time and emergence of immune-evading SARS-CoV-2 variants of concern (VOCs) indicate the need for vaccine boosters. LYB001 is an innovative recombinant SARS-CoV-2 vaccine which displays a repetitive array of the Spike glycoprotein’s receptor binding domain (RBD) on a virus-like particle (VLP) vector to boost the immune system, produced using a Covalink plug-and-display protein binding technology.MethodsThe safety and immunogenicity of LYB001 as a heterologous booster at an interval of 6-12 months was assessed in 119 participants receiving a booster with (1) 30μg LYB001 ((I-I-30L) or CoronaVac (I-I-C), (2) escalated dose of 60μg LYB001 (I-I-60L) or CoronaVac in a ratio of 2:1 after two-dose primary series of inactivated COVID-19 vaccine in part 1 of this study, or (3) 30μg LYB001 (I-I-I-30L) after three-dose primary series of inactivated COVID-19 vaccine in part 2 of this study.ResultsA well-tolerated reactogenicity profile was observed for LYB001 as a heterologous booster, with adverse reactions predominantly being mild in severity and transient. The peak neutralizing antibody response was observed at 28 days after booster, with GMT (95%CI) against prototype SARS-CoV-2 being 1237.8 (747.2, 2050.6), 554.3 (374.6, 820.2), 181.9 (107.6, 307.6) and 1200.2 (831.5, 1732.3) in the I-I-30L, I-I-60L, I-I-C, and I-I-I-30L groups, respectively. LYB001 also elicited a cross-neutralizing antibody response against the BA.4/5 strain, dominant during the study period, with GMT being 201.1 (102.7, 393.7), 63.0 (35.1, 113.1), 29.2 (16.9, 50.3) and 115.3 (63.9, 208.1) at 28 days after booster in the I-I-30L, I-I-60L, I-I-C, and I-I-I-30L groups, respectively. Additionally, RBD-specific IFN-γ, IL-2, IL-4 secreting T cells, as measured by ELISpot assay, dramatically increased (more than 10 times versus baseline) at 14 days after a single LYB001 booster.ConclusionsOur data confirm the favorable safety and immunogenicity profile of the LYB001 vaccine when used as a heterologous booster, and support the continued clinical development of this promising candidate that utilize VLP platform to provide protection against COVID-19.Trial registrationhttps://www.clinicaltrials.gov(No.NCT05928455,https://www.clinicaltrials.gov/study/NCT05928455)
Understanding customer attitude toward advergames: an extended TAM approach
Authors: Jami Pour Mona , Kazemi Zohre , Moeini Hossein 
Published: July 2023

PurposeAdvergames have attracted the attention of scholars and practitioners as a new way of increasing customer engagement and advertising effectiveness. Gamified ads provide an exciting and persuasive environment for customers rather than non-gamified advertisements. Despite the growing spending on advergames projects, the understanding of customer attitude regarding advergames has received less attention and there are not enough studies about advergames. Therefore, the purpose of the current study is to design a novel TAM-based model of determinants of customer attitudes toward advergames to enhance customer engagement and purchase intention.Design/methodology/approachTo obtain this end, the mixed method was applied. In the first step, the main determinants of customer attitude towards advergames were identified by a literature review as well as semi-structured interviews. In the second step, the proposed technology acceptance model (TAM)-based model was validated by survey method through players of advergames. A total of 15 interviews were conducted in the qualitative phase and 102 completed questionnaires were analyzed in the survey method.FindingsThe results of the qualitative approach indicate that the main determinants of attitude towards advertisements can be classified into three categories, which are added to TAM as external variables. The results of the survey approach reveal that advertising content and game-related factors have a significant positive effect on perceived ease of use (PEOU). The advertising content and player-related factors also significantly affect perceived usefulness (PU). PU and PEOU also positively and significantly affect customer attitude. The findings show that the new TAM-based model can be considered as a robust model for explaining customer attitude toward advergame acceptance.Research limitations/implicationsThe research findings can assist digital marketers to have a big picture of customer attitudes regarding advergames and implement these innovative digital-enabled advertising strategies successfully. The findings further suggest considering marketing/advertising aspects and game-related aspects as well as individual factors to design advergames.Originality/valueAdvergames have become one of the priorities for digital marketers to enhance brand awareness and customer engagement, yet there is no study identifying determinants of attitude by considering multi-aspects of advergames. The most important theoretical contribution of the current study is to design a new extended TAM-based model which integrates behavioral variables (PEOU and PU) with factors related to the advergames context.
Supersonic combustion of n-Heptane droplets with cavity-based fuel injection
Authors: Mohamadi Mehdi , Tahsini AmirMahdi 
Published: July 2023

Purpose
The purpose of this study is to investigate the combustion of the n-Heptane droplets in the supersonic combustor with a cavity-based fuel injection configuration. The focus is on the impacts of the droplet size on combustion efficiency.

Design/methodology/approach
The finite volume solver is developed to simulate the two-phase reacting turbulent compressible flow using a single step reaction mechanism as finite rate chemistry. Three different fuel injection settings are studied for the considered physical geometry and flow conditions: the gas fuel injection, small droplet liquid fuel injection and big droplet fuel. The fuel is injected as a slot wall jet from the bottom of the cavity.

Findings
The results show that using the small droplet size, the complete fuel consumption and combustion efficiency can be achieved but using the big droplet sizes, most fuel exit the combustor in the liquid phase and gasified unburned fuel. It is also demonstrated that the cavity's temperature distribution of the liquid fuel case is different from the gas fuel, and two flame branches are observed there due to the droplet evaporation and combustion in the cavity.

Originality/value
To the best of the authors’ knowledge, this study is performed for the first time on the combustion of the n-Heptane fuel droplets in scramjet configuration, which is promising propulsion system for the future economic flights.
Investigation of architecture and architectural engineering online education; educator experience, self-efficacy and success
Authors: Mosier Rachel , Adhikari Sanjeev , Langar Sandeep 
Published: July 2023

PurposeThose who believe they excel at architecture or engineering education are more likely to succeed based on self-efficacy principles. To investigate educator self-efficacy and success in the Online Learning Environment (OLE), a set of relationships are observed which describe correlations between experience and potential.Design/methodology/approachAn online survey instrument was distributed the fall after COVID-19 university closures. Respondents were asked to reflect on their level of experience teaching and their ability to teach online. All analyzed data were subjected to descriptive and inferential statistics using the SPSS 22.0 statistical software package. The compatibility of the variables with normal distribution was tested using the Kolmogorov–Smirnov and Shapiro–Wilk methods. Variables comparisons were performed using non-parametric tests (Kruskal Wallis test, Mann Whitney U test). The relationships between quantitative variables were examined using the Spearman Rank Correlation and comparisons formed from the qualitative variables were tested using the Pearson Chi-Square and Fisher Exact methods.FindingsEducator self-efficacy was determined throughout the COVID-19 transition. Possessing online teaching experience is related to the perceptions that architectural education can be delivered entirely online. A relationship was found for educators who previously taught using OLE and who had experience with delivering and developing OLE.Practical implicationsIt is incumbent on educators and administrators to continue to learn how to best accommodate student learning. The strong relationship for R1: Total teaching experience (IV) and perceptions of whether AEC education can be delivered completely online, points to having educators with a depth of experience and being open to change. The strong relationship shown for R2: Have you ever taught using an online method before January 2020 and Experience in developing online materials demonstrates that a variety of experience will also support educators in a time of change. These relationships illustrate how educator efficacy can provide support for educators during times of crisis.Originality/valueU.S. Architectural and Architectural Engineering educator pandemic OLE self-efficacy has not been previously been a focus of research efforts. This research adds to the body of knowledge by demonstrating how relationships between teaching experience and OLE can encourage educator self-efficacy during a crisis. Statistical analyses found a strong relationship between total teaching experience and perceptions that AEC education can be delivered completely online. A strong relationship was found between online teaching experience and positive experiences in developing online materials.
Sustainable HRM, training for employability and organizational outcomes: the moderating role of competitive intensity
Authors: Martini Mattia , Riva Egidio , Marafioti Elisabetta 
Published: July 2023

PurposeThe present study connects the literature on sustainable HRM with that on employability to investigate the relationship between sustainability-oriented human resource actions and organizational outcomes. More specifically, this study explores how training for employability affects the employer–employee relationship and employee retention. Furthermore, this study considers competitive intensity as a potential moderator in these relationships.Design/methodology/approachThe analyses draw on the fourth European Company Survey (ECS 2019) with a sample of 21?869 firms with more than ten employees. Two separate logistic regression models were used to test the hypothesis.FindingsThe results show that training for employability contributes to improving the employer–employee relationship and that competitive intensity positively shapes this relationship. Contextually, training for employability reduces the overall employee retention of the firm.Originality/valueAlthough this study supports the potential win–win nature of employability support, especially for companies that operate in competitive markets and an uncertain environment, it also highlights the existence of paradoxical sustainability tensions that should be managed by employers.
The role of institutional efficiency in achieving the SDGs: evidence from Africa
Authors: Musah Alhassan 
Published: July 2023

PurposeThe objective of this study is to analyze the influence of institutional quality on the attainment of the Sustainable Development Goals (SDGs) using a data set comprising 45 African nations during the timeframe 2000 to 2020.Design/methodology/approachThe data are divided into two periods, with the Millennium Development Goals (MDGs) data covering the years 2000–2015 and the SDGs data spanning from 2015 to 2020. Controlling for other factors, the researcher employs an index of institutional quality and applies the generalized method of moments (GMM) method to analyze the data.FindingsThe findings demonstrate a noteworthy inverse relationship between institutional quality and the achievement of both the MDGs and SDGs. The findings reveal a significant and positive link between economic growth and the achievement of the MDGs, while the impact on the SDGs is shown to be insignificant. Population growth significantly drives the SDGs. The results further reveal that trade openness and industrialization contribute positively to the achievement of both the MDGs and SDGs.Practical implicationsThe findings emphasize the importance of improving institutional quality, promoting economic growth and supporting trade openness and industrialization for sustainable development in African countries.Originality/valueThe contribution of the study is twofold. Firstly and to the best of the author’s understanding, this research marks an initial endeavor to empirically investigate the nexus between institutional quality and the SDGs in the context of Africa. Secondly, it adds novelty to the literature by examining how institutional quality influences both the SDGs and their precursor the MDGs, providing insights into the actual contribution of institutions to development within the framework of these two major global compacts.
Multi-tier sustainable supply chain management: a case study of a global food retailer
Authors: Oyedijo Adegboyega , Kusi-Sarpong Simonov , Mubarik Muhammad Shujaat , Khan Sharfuddin Ahmed , Utulu Kome 
Published: July 2023

Purpose
Implementing sustainable practices in multi-tier supply chains (MTSCs) is a difficult task. This study aims to investigate why such endeavours fail and how MTSC partners can address them.

Design/methodology/approach
A single-case study of a global food retail company was used in this study. Semi-structured interviews with the case firm and its first- and second-tier suppliers were used to collect data, which were then qualitatively analysed using thematic analysis.

Findings
Major barriers impeding the implementation of sustainability in multi-tier food supply chains were revealed such as the cost of sustainability, knowledge gap, lack of infrastructure and supply chain complexity. Furthermore, the findings reveal five possible solutions such as multi-tier collaboration and partnership, diffusion of innovation along the chain, supply chain mapping, sustainability performance measurement and capacity building, all of which can aid in the improvement of sustainability practices.

Research limitations/implications
Future research should investigate how specific barriers and drivers affect specific aspects of sustainability, pointing practitioners to specific links between the variables that can aid in tailoring sustainability oriented investment.

Practical implications
This research supports managerial comprehension of MTSC sustainability, pointing out ways to improve sustainability performance despite the complex multi-tier system of food supply chains.

Originality/value
The research on MTSC sustainability is still growing, and this research contributes to the debate about how MTSCs can become more sustainable from the perspective of the triple bottom line, particularly food supply chains which face significant sustainability challenges.
Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes
Authors: Matsuda Yasuyuki , Yamauchi Hajime , Hara Hideki 
Published: July 2023

AbstractThe high mortality rate associated with Listeria monocytogenes can be attributed to its ability to invade the body systemically and to activate inflammasomes. Both of these processes are facilitated by expressing a major virulence factor known as listeriolysin O, a 56 kDa pore‐forming protein encoded by the hly gene. Listeriolysin O plays a crucial role in the pathogenesis of the bacterium by facilitating the escape of the pathogen from the phagosome into the cytosol. This process is essential for the successful establishment of infection. In addition, listeriolysin O is known as an immunomodulator that activates host signal transduction. In addition to listeriolysin O, Listeria expresses a variety of bacterial ligands, such as lipoteichoic acid, nucleotide, and flagellin, that are recognized by host intracellular pattern‐recognition receptors including Nod‐like receptors, AIM2‐like receptors, and RIG‐I‐like receptors. This review introduces intracellular recognition of Listeria monocytogenes since recent studies have revealed that the activation of inflammasome exacerbates Gram‐positive bacteria infection.
Recourse as shadow equity: Evidence from commercial real estate loans
Authors: Glancy David , Kurtzman Robert , Loewenstein Lara , Nichols Joseph 
Published: July 2023

AbstractWe study the role that recourse plays in the commercial real estate loan contracts of the largest U.S. banks. We find that recourse is valued by lenders as a substitute for conventional equity. At origination, recourse loans have rate spreads that are about 20 basis points lower and loan‐to‐value ratios that are almost 3 percentage points higher than nonrecourse loans. Dynamically, recourse affects loan modification negotiations by providing additional bargaining power to the lender. Recourse loans were half as likely to receive accommodation during the COVID‐19 pandemic, and the modifications that did occur entailed a relatively smaller reduction in payments.
The effect of double filtration plasmapheresis and corticosteroids on patients with anti‐dipeptidyl‐peptidase‐like protein 6 encephalitis
Authors: Wan Wenbin , Pan Yuanmei , Chen Ying , Bai Shuwei , Yao Xiaoying , Lin Yan , Wu Jun , Ni Liping , Mei Yufang , Qiu Huiying , Zhou Yan , Hao Yong , Guan Yangtai 
Published: July 2023

AbstractIntroductionAnti‐dipeptidyl‐peptidase‐like protein 6 (DPPX) encephalitis is a rare condition with varied symptoms including gastrointestinal issues, weight loss, cognitive and mental dysfunction, and hyperexcitability of the central nervous system.MethodsWe studied five patients with anti‐DPPX encephalitis who received immunotherapy, specifically DFPP, at our hospital. We analyzed their clinical symptoms, lab results, electrophysiological and imaging findings, and outcomes with immunotherapy.ResultsPatients presented with cognitive dysfunction, tremor, seizures, psychiatric disturbances, and cerebellar and brainstem dysfunction. Magnetic resonance imaging (MRI) showed brain abnormalities in one patient and elevated cerebrospinal fluid (CSF) protein levels in two patients. Antibodies against DPPX were detected in all patients and in CSF in two patients. One patient had antibodies against anti‐CV2/contactin response mediator protein 5 (CRMP5). All patients responded well to DFPP and corticosteroids.ConclusionDFPP may be an effective treatment for anti‐DPPX encephalitis. Further research is needed to understand disease progression and evaluate immunotherapy efficacy.