bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult skin fibroblast state change in murine wound healing
Authors: Gharbia Fatma Z. , Abouhashem Ahmed S. , Moqidem Yomna A. , Elbaz Ahmed A. , Abdellatif Ahmed , Singh Kanhaiya , Sen Chandan K. , Azzazy Hassan M. E. 
Published: January 2023

AbstractWound healing is a well-organized dynamic process involving coordinated consecutive phases: homeostasis, inflammation, proliferation and resolution. Fibroblasts play major roles in skin wound healing such as in wound contraction and release of growth factors which are of importance in angiogenesis and tissue remodeling. Abnormal fibroblast phenotypes have been identified in patients with chronic wounds. In this work, we analyzed scRNA-seq datasets of normal and wounded skin from mice at day 4 post-wound to investigate fibroblast heterogeneity during the proliferative phase of wound healing. Compositional analysis revealed a specific subset of fibroblast (cluster 3) that primarily increased in wounded skin (14%) compared to normal skin (3.9%). This subset was characterized by a gene signature marked by the plasma membrane proteins Sfrp2 + Sfrp4 + Sfrp1 + and the transcription factors Ebf1 + Prrx1 + Maged1 + . Differential gene expression and enrichment analysis identified epithelial to mesenchymal transition (EMT) and angiogenesis to be upregulated in the emerging subset of fibroblasts of the wounded skin. Using two other datasets for murine wounded skin confirmed the increase in cluster 3-like fibroblasts at days 2, 7 and 14 post-wounding with a peak at day 7. By performing a similarity check between the differential gene expression profile between wounded and normal skin for this emerging fibroblast subset with drug signature from the ConnectivityMap database, we identified drugs capable of mimicking the observed gene expression change in fibroblasts during wound healing. TTNPB, verteprofin and nicotinic acid were identified as candidate drugs capable of inducing fibroblast gene expression profile necessary for wound healing. On the other hand, methocarbamol, ifosfamide and penbutolol were recognized to antagonize the identified fibroblast differential expression profile during wound healing which might cause delay in wound healing. Taken together, analysis of murine transcriptomic skin wound healing datasets suggested a subset of fibroblasts capable of inducing EMT and further inferred drugs that might be tested as potential candidates to induce wound closure.
Objective quantification of homophily in children with and without disabilities in naturalistic contexts
Authors: Banarjee Chitra , Tao Yudong , Fasano Regina M. , Song Chaoming , Vitale Laura , Wang Jue , Shyu Mei-Ling , Perry Lynn K. , Messinger Daniel S. 
Published: January 2023

AbstractHomophily, the tendency for individuals to preferentially interact with others similar to themselves is typically documented via self-report and, for children, adult report. Few studies have investigated homophily directly using objective measures of social movement. We quantified homophily in children with developmental disabilities (DD) and typical development (TD) using objective measures of position/orientation in preschool inclusion classrooms, designed to promote interaction between these groups of children. Objective measurements were collected using ultra-wideband radio-frequency tracking to determine social approach and social contact, measures of social movement and interaction. Observations of 77 preschoolers (47 with DD, and 30 TD) were conducted in eight inclusion classrooms on a total of 26 days. We compared DD and TD groups with respect to how children approached and shared time in social contact with peers using mixed-effects models. Children in concordant dyads (DD-DD and TD-TD) both moved toward each other at higher velocities and spent greater time in social contact than discordant dyads (DD-TD), evidencing homophily. DD-DD dyads spent less time in social contact than TD-TD dyads but were comparable to TD-TD dyads in their social approach velocities. Children’s preference for similar peers appears to be a pervasive feature of their naturalistic interactions.
Comparing the accuracy of ultrasound-based measurements of the cervical vagus nerve
Authors: Dörschner Johann , Pelz Johann Otto , Kerner Alexander Michael , Labuschagne Jason John , Hammer Niels , Löffler Sabine 
Published: January 2023

AbstractVagus nerve stimulation (VNS) has become a promising therapy especially for drug resistant epilepsy and other pathologies. Side effects or missing therapeutic success are observed due to cuff electrodes that are too narrow or too wide. Preoperative high-resolution ultrasound is used to evaluate the size of the cervical vagus nerve (CVN) to estimate the size of cuff electrodes for VNS. It remains unclear how precise ultrasound reflects the CVN dimensions, which has been the objective of this study. CVN cross-sections and diameters were investigated in 23 sides from 12 bodies, using ultrasound, histology, and CVN casting in situ as a reference. Morphometric data were obtained including fascicle count and nerve composition in histology. CVN yielded significant side-, age-, and BMI-related differences. CVN cross-sections were smaller in ultrasound when compared to casting and histology (1.5 ± 0.4 vs. 3.1 ± 0.9 vs. 2.3 ± 0.7 mm2). With the given setting in ultrasound, CVN cross-sections were consistently underestimated when compared to casting. Ultrasound-based cross-section measurements are related to a biased estimation of CVN size. A factor to correct for method related differences may help to adjust for accurate cuff electrode sizes for patient needs and to reduce undesired effects and potentially material consumption.
The renin-angiotensin system modulates endotoxic postconditioning of exacerbated renal vasoconstriction in preeclamptic offspring
Authors: Morgaan Hagar A. , Sallam Marwa Y. , El-Gowelli Hanan M. , El-Gowilly Sahar M. , El-Mas Mahmoud M. 
Published: January 2023

AbstractWe recently reported exacerbated endotoxic signs of neuroinflammation and autonomic defects in offspring of preeclamptic (PE) dams. Here, we investigated whether PE programming similarly modifies hemodynamic and renal vasoconstrictor responsiveness to endotoxemia in PE offspring and whether this interaction is modulated by gestational angiotensin 1–7 (Ang1-7). Preeclampsia was induced by gestational treatment with L-NAME. Adult offspring was challenged with lipopolysaccharides (LPS, 5 mg/kg) and systolic blood pressure (SBP) and renal vasoconstrictions were assessed 4 h later. Male, but not female, offspring of PE rats exhibited SBP elevations that were blunted by LPS. Renal vasoconstrictions induced by angiotensin II (Ang II), but not phenylephrine, were intensified in perfused kidneys of either sex. LPS blunted the heightened Ang II responses in male, but not female, kidneys. While renal expressions of AT1-receptors and angiotensin converting enzyme (ACE) were increased in PE offspring of both sexes, ACE2 was upregulated in female offspring only. These molecular effects were diminished by LPS in male offspring. Gestational Ang1-7 caused sex-unrelated attenuation of phenylephrine vasoconstrictions and preferentially downregulated Ang II responses and AT1-receptor and nuclear factor-kB (NFkB) expressions in females. Together, endotoxemia and Ang1-7 offset in sexually-related manners imbalances in renal vasoconstriction and AT1/ACE/ACE2 signaling in PE offspring.
Physical firmness increases structural alignment
Authors: Cecutti Lorenzo , Lee Spike W. S. 
Published: January 2023

AbstractRaising one's jammed fist is not just a common pictorial representation of struggle against the establishment but turns out to reflect a deeper connection between sensorimotor states and beliefs. The present research investigated how physical firmness, manipulated through muscle tightening, might shape beliefs. The central hypothesis, structural alignment, was tested against two other competing predictions: content extremity and content matching. Three studies provided evidence supporting structural alignment but not content matching or extremity. Specifically, the correlation between intelligence and personality lay beliefs (Studies 1–2), and the correlation between individualizing and binding moral foundations (Study 3) increased when participants jammed their fist (Study 1) or clenched their jaw (Studies 2–3). These effects emerged in the absence of mean-level differences (which would have reflected content matching or extremity). Moreover, they did not seem attributable to response bias or tiredness. An additional study suggested decent rates of compliance with experimental instructions that were comparable between conditions. Overall, sensorimotor experiences such as physical firmness can align higher-order cognitions such as beliefs in ways that are distinct from prior demonstrations of embodied cognition effects.
Preclinical evaluation of the polycaprolactone-polyethylene glycol electrospun nanofibers containing egg-yolk oil for acceleration of full thickness burns healing
Authors: Shadman-Manesh Vida , Gholipour-Kanani Adeleh , Najmoddin Najmeh , Rabbani Shahram 
Published: January 2023

AbstractConsidering the great potential of egg yolk oil (EYO) in management of burn wounds and superb biological properties of polycaprolactone (PCL) and polyethylene glycol (PEG), hereby, a PCL-PEG-EYO scaffold was developed by electrospinning method for burn healing. The physico-chemical characterizations were performed using SEM, FTIR and contact angle tests. The biological properties of the fabricated scaffolds were evaluated by antibacterial test, in vitro cell culturing, MTT assay and in vivo experiments. The SEM images of PCL-PEG-EYO nanofibers demonstrated a uniform bead-free morphology with 191 ± 61 nm diameter. The fabricated scaffold revealed hydrophilicity with the water contact angel of 77°. No cytotoxicity was observed up to 7 days after cell culturing onto the PCL-PEG-EYO nanofibrous surface. The presence of EYO in the PCL-PEG-EYO scaffold meaningfully improved the cell viability, proliferation and attachment compared to PCL-PEG scaffold. Moreover, the PCL-PEG-EYO scaffolds demonstrated antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa bacteria strain. Finally, a statistically significant enhancement in wound closure, re-epithelialization, angiogenesis and collagen synthesis was observed at the end of 21-day treatment period using PCL-PEG-EYO nanofibrous scaffold. Overall, the PCL-PEG-EYO nanofibrous scaffolds demonstrated a great potential in management of full thickness burn wounds in vivo.
Phonetic categorization relies on motor simulation, but combinatorial phonological computations are abstract
Authors: Berent Iris , Fried Peter J. , Theodore Rachel M. , Manning Daniel , Pascual-Leone Alvaro 
Published: January 2023

AbstractTo identify a spoken word (e.g., dog), people must categorize the speech steam onto distinct units (e.g., contrast dog/fog,) and extract their combinatorial structure (e.g., distinguish dog/god). However, the mechanisms that support these two core functions are not fully understood. Here, we explore this question using transcranial magnetic stimulation (TMS). We show that speech categorization engages the motor system, as stimulating the lip motor area has opposite effects on labial (ba/pa)- and coronal (da/ta) sounds. In contrast, the combinatorial computation of syllable structure engages Broca’s area, as its stimulation disrupts sensitivity to syllable structure (compared to motor stimulation). We conclude that the two ingredients of language—categorization and combination—are distinct functions in human brains.
Replacing discontinued Big Tech mobility reports: a penetration-based analysis
Authors: Finazzi Francesco 
Published: January 2023

AbstractPeople mobility data sets played a role during the COVID-19 pandemic in assessing the impact of lockdown measures and correlating mobility with pandemic trends. Two global data sets were Apple’s Mobility Trends Reports and Google’s Community Mobility Reports. The former is no longer available online, while the latter is no longer updated since October 2022. Thus, new products are required. To establish a lower bound on data set penetration guaranteeing high adherence between new products and the Big Tech products, an independent mobility data set based on 3.8 million smartphone trajectories is analysed to compare its information content with that of the Google data set. This lower bound is determined to be around 10−4 (1 trajectory every 10,000 people) suggesting that relatively small data sets are suitable for replacing Big Tech reports.
Considerations in Utilizing Translanguaging Practices to Meet the Language Needs of Maya Children in U.S. Schools
Authors: Hernández Amalia W. , Campos Iván , Zyskind Karen Zuniga 
Published: January 2023

Purpose:
Meeting the needs of Maya children in U.S. schools requires extensive training. Research is lacking in best practices to support students with intersectional identities. This article provides a roadmap centralized on Maya children's experiences, acknowledging the linguistic diversity of Maya immigrants, their language and cultural practices, and their integration into or exclusion from minoritized and White neighborhoods in the United States to provide a starting point for culturally responsive service delivery.

Conclusions:
Supporting the needs of Maya children requires an approach that values and recognizes their intersectional identities while developing collaborative relationships with students, families, and educators. Application of the roadmap will support to (a) identify educational obstacles faced by Maya children, (b) integrate translanguaging to support best practices for educational success, and (c) determine service delivery considerations for bilingual/trilingual, multicultural children. More research on the topic is needed to establish evidence-based practice guidelines to utilize a translanguaging pedagogy within speech-language pathology.
Enhanced diversity scheme for orthogonal frequency division multiplexing systems over doubly selective fading channels
Authors: Xie Yuelei , Li Wenshan , Wan Jie , Ouyang Shan 
Published: January 2023

AbstractFrequency‐time selective fading degrades the performance of communication systems, but it also provides an opportunity to collect multipath diversity and Doppler diversity. In this paper, an oversampled grouped‐linear‐constellation‐precoding (GLCP) scheme is proposed for orthogonal frequency division multiplexing (OFDM) systems to extract the diversity inherent in doubly selective fading channels. In the proposed scheme, GLCP is employed to precode the information symbols of OFDM at the transmitter, and the precoded OFDM symbols are oversampled in the time domain at the receiver. A full‐groups maximum likelihood (ML) decoder and a successive group decoder to decode the oversampled OFDM symbols with diversity gains are developed. The successive group decoder combines the group ML decoding algorithm with a block‐decision‐feedback‐equalization (BDFE) algorithm. The proposed scheme can take advantage of both the GLCP scheme and the oversampling scheme to achieve multipath diversity gains and Doppler diversity gains in doubly selective fading channels. Simulation results show that the proposed scheme can significantly improve the performance of OFDM systems in the frequency selective fading channel and the doubly selective fading channel in terms of bit error ratio, indicating that the diversity gains can be greatly enhanced by the proposed scheme in doubly selective fading channels.
Computing the gravitational potential on nested meshes using the convolution method
Authors: Vorobyov Eduard I. , McKevitt James , Kulikov Igor , Elbakyan Vardan 
Published: January 2023

Aims. Our aim is to derive a fast and accurate method for computing the gravitational potential of astrophysical objects with high contrasts in density, for which nested or adaptive meshes are required.
Methods. We present an extension of the convolution method for computing the gravitational potential to the nested Cartesian grids. The method makes use of the convolution theorem to compute the gravitational potential using its integral form.
Results. A comparison of our method with the iterative outside-in conjugate gradient and generalized minimal residual methods for solving the Poisson equation using nonspherically symmetric density configurations has shown a comparable performance in terms of the errors relative to the analytic solutions. However, the convolution method is characterized by several advantages and outperforms the considered iterative methods by factors 10–200 in terms of the runtime, especially when graphics processor units are utilized. The convolution method also shows an overall second-order convergence, except for the errors at the grid interfaces where the convergence is linear.
Conclusions. High computational speed and ease in implementation can make the convolution method a preferred choice when using a large number of nested grids. The convolution method, however, becomes more computationally costly if the dipole moments of tightly spaced gravitating objects are to be considered at coarser grids.
High-mass eclipsing binaries: A testbed for models of interior structure and evolution
Authors: Pavlovski K. , Southworth J. , Tkachenko A. , Van Reeth T. , Tamajo E. 
Published: January 2023

Aims. The surface chemical compositions of stars are affected by physical processes that bring the products of thermonuclear burning to the surface. Despite their potential in helping us understand the structure and evolution of stars, elemental abundances are available for only a few high-mass binary stars. We aim to enlarge this sample by determining the physical properties and photospheric abundances for four eclipsing binary systems that contain high-mass stars: V1034 Sco, GL Car, V573 Car, and V346 Cen. The components have masses of 8–17 M⊙, have effective temperatures from 22 500 to 32 200 K, and are all on the main sequence.
Methods. We present new high-resolution and high signal-to-noise spectroscopy from the High Accuracy Radial velocity Planet Searcher (HARPS), which we analysed using spectral disentangling and non-local thermodynamic equilibrium spectral synthesis. We modelled existing light curves and new photometry from the Transiting Exoplanet Survey Satellite (TESS).
Results. We measure the stellar masses to a 0.6–2.0% precision, radii to a 0.8–1.7% precision, effective temperatures to a 1.1–1.6% precision, and abundances of C, N, O, Mg, and Si. The abundances are similar to those found in our previous studies of high-mass eclipsing binaries; our sample now comprises 25 high-mass stars in 13 binary systems. We also find tidally excited pulsations in V346 Cen.
Conclusions. These results reinforce our previous conclusions: interior chemical element transport is not as efficient in binary star components as in their single-star counterparts in the same mass regime and evolutionary stage, possibly due to the effects of tidal forces. Our ultimate goal is to provide a larger sample of OB-type stars in binaries to enable a thorough comparison to stellar evolutionary models, as well as to single high-mass stars.
Modeling Solar Orbiter dust detection rates in the inner heliosphere as a Poisson process
Authors: Kočiščák S. , Kvammen A. , Mann I. , Sørbye S. H. , Theodorsen A. , Zaslavsky A. 
Published: January 2023

Context.Solar Orbiter provides dust detection capability in the inner heliosphere, but estimating physical properties of detected dust from the collected data is far from straightforward.Aims.First, a physical model for dust collection considering a Poisson process is formulated. Second, it is shown that dust on hyperbolic orbits is responsible for the majority of dust detections with Solar Orbiter’s Radio and Plasma Waves (RPW). Third, the model for dust counts is fitted to Solar Orbiter RPW data and parameters of the dust are inferred, namely radial velocity, hyperbolic meteoroids predominance, and the solar radiation pressure to gravity ratio as well as the uncertainties of these.Methods.Nonparametric model fitting was used to get the difference between the inbound and outbound detection rate and dust radial velocity was thus estimated. A hierarchical Bayesian model was formulated and applied to available Solar Orbiter RPW data. The model uses the methodology of integrated nested Laplace approximation, estimating parameters of dust and their ncertainties.Results.Solar Orbiter RPW dust observations can be modeled as a Poisson process in a Bayesian framework and observations up to this date are consistent with the hyperbolic dust model with an additional background component. Analysis suggests a radial velocity of the hyperbolic component around (63 ± 7) km s−1with the predominance of hyperbolic dust being about (78 ± 4)%. The results are consistent with hyperbolic meteoroids originating between 0.02 AU and 0.1 AU and showing substantial deceleration, which implies effective solar radiation pressure to a gravity ratio ≳ 0.5. The flux of the hyperbolic component at 1 AU is found to be (1.1 ± 0.2) × 10−4m−2s−1and the flux of the background component at 1 AU is found to be (5.4 ± 1.5) × 10−5m−2s−1.
Pulmonary Findings in Hospitalized COVID-19 Patients Assessed by Lung Ultrasonography (LUS) – A Prospective Registry Study
Authors: Barner Anna , Burian Egon , Simon Alexander , Castillo Katty , Waschulzik Birgit , Braren Rickmer , Heemann Uwe , Osterwalder Joseph , Spiel Alexander , Heim Markus , Stock Konrad Friedrich 
Published: January 2023

Abstract
Purpose This prospective two-centre study investigated
localisation-dependent lesion patterns in COVID-19 with standard lung ultrasonography (LUS)
and their relationship with thoracic computed tomography (CT) and clinical parameters.
Materials and Methods Between April 2020 and April 2021, 52 SARS-CoV-2-positive
patients in two hospitals were examined by means of LUS for “B-lines”, fragmented
pleura, consolidation and air bronchogram in 12 lung regions and for pleural effusions. A
newly developed LUS score based on the number of features present was correlated with clinical
parameters (respiration, laboratory parameters) and the CT and analysed with respect to the
30- and 60-day outcome. All patients were offered an outpatient LUS follow-up.
Results The LUS and CT showed a bilateral, partially posteriorly
accentuated lesion distribution pattern. 294/323 (91%) of CT-detected lesions were pleural.
The LUS score showed an association with respiratory status and C-reactive protein; the
correlation with the CT score was weak (Spearman’s rho = 0.339, p < 0.001). High LUS scores
on admission were also observed in patients who were discharged within 30 days. LUS during
follow-up showed predominantly declining LUS scores.
Conclusion The LUS score reflected the clinical condition of the
patients. No conclusion could be made on the prognostic value of the LUS, because of the low
event rate. The LUS and CT score showed no sufficient correlation. This is probably due to
different physical principles, which is why LUS could be of complementary value.