bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using some natural essential oils and their nano-emulsions for ammonia management, anti-stress and prevention of streptococcosis in Nile tilapia, Oreochromis niloticus
Authors: Korni Fatma M. M. , Mohammed Asmaa N. , Moawad Usama K. 
Published: February 2023

AbstractThe current study aimed to investigate the efficacy of dietary thyme essential oil (TEO), Nigella sativa essential oil (NSEO), thyme essential oil nano-emulsion (TEO-NE), and Nigella sativa essential oil nano-emulsion (NSEO-NE) in reducing total ammonia nitrogen (TAN), improving immune response, mitigating stress, and acting as anti-inflammatory agents as well as preventing streptococcosis infection in Oreochromis niloticus (O. niloticus). Fish (N = 330, 14 ± 2 g) were divided into 10 groups of 11 fish each, with three replicates in each group. The negative and positive controls were fed a control diet, while the third group was given 1% TEO. Moreover, the fourth group of fish was given 2% TEO. The fifth and sixth groups were fed 1% TEO-NE and 2% TEO-NE, respectively. The seventh, eighth, ninth, and tenth groups were fed 1% NSEO, 2% NSEO, 1% NSEO-NE, and 2% NSEO-NE, respectively. After dietary intake of TEO, NSEO, and their nano-emulsions for 28 days, the mean values of TAN levels in the water of fish aquaria had a significant reduction in the group fed 2% TEO-NE compared to the control group. On the contrary, NSEO-NE at the same concentration had no significant effect on TAN levels. The levels of lysozyme, complement 5, and IgM increased in all feeding groups compared to the control group. Concerning cortisol level as a stress indicator, it was decreased in all feeding groups compared to the control. Also, the current experiment overall showed a significant decrease in the expression level of pro-inflammatory tumor necrosis factor (TNF-α) gene in the gills of fish groups fed TEO, TEO-NE, NS, and NS-NE relative to the β-actin gene. Oppositely, there was an increase in the expression level of the anti-inflammatory transforming growth factor (TGF-β). In the current study, TEO-NE and NSEO-NE showed a better effect on preventing streptococcosis in O. niloticus with no mortality than 1% TEO and NSEO, respectively. Furthermore, there was a 12.5% mortality rate and an 84.99 RPS in the group fed 1% TEO and injected with Streptococcus inae. On the other hand, the groups fed 1 and 2% NSEO showed 37.5 and 25% mortality rate, respectively and 54.99 and 69.99 RPS. In conclusion, the nano-emulsion either TEO or NSEO had the superior effect. For bulk status, the TEO had superior effect than NSEO. The study needs more investigations for ammonia, either on the mode of action or over a longer period.
A revised taxonomy and estimate of species diversity for western North American Lampetra
Authors: Carim K. J. , Larson D. C. , Helstab J. M. , Young M. K. , Docker M. F. 
Published: February 2023

AbstractLampreys are an ancient lineage of jawless fish for which the relationships among some lineages are uncertain. We addressed these information gaps for Lampetra species with a focus on western North America. Phylogenetic analysis using all publicly available sequences of two mitochondrial genes—cyt b and COI—supported designation of western North American Lampetra as a distinct genus from Lampetra in Europe, Asia, and eastern North America. Species delimitation analysis of cyt b sequences identified seven species, only three of which are currently recognized. Lampetra ayresii and L. richardsoni, regarded as separate under the “paired species concept,” were not genetically distinct; we recommend synonymizing L. richardsoni with L. ayresii because the latter has precedence, yet continuing to recognize each ecotype using its current common name. Other than the widespread L. ayresii clade, all other species exhibited limited ranges often restricted to one or two locations. Within headwaters of the Willamette River, L. ayresii demonstrated strong genetic structure and lack of gene flow among subbasins, indicating that the subbasin scale may represent an appropriate management unit. However, the appropriate management scale in other areas may differ based on evolutionary histories and gene flow. Subsequent work is needed across western North America to better delineate the ranges of the aforementioned species and to evaluate whether other unrecognized taxa in this lineage may be present.
Glomerular deposition of fibrinogen predicts good prognosis of IgA nephropathy: a single-center cohort study
Authors: Yang Wei-guang , Zhu Rong , Zheng Jian-nan , Zhang Jun-xiao , Liu Nan , Yao Li , Liu Lin-lin 
Published: February 2023

Abstract
Purpose
It has been proven that fibrinogen deposition exists in IgA nephropathy (IgAN), but its clinical significance has not been identified. We aim to investigate the clinical implication of fibrinogen deposition in evaluating the activity and prognosis of IgA nephropathy.

Methods
In this cohort, 935 adult IgAN patients were divided into 3 groups according to the intensity of glomerular fibrinogen deposition. Primary outcome refers to a composite event of either a ≥ 50% reduction in eGFR or ESRD (eGFR < 15 ml/min/1.73m2, dialysis, or renal transplantation). Factors associated with fibrinogen deposition and prognosis were identified.

Results
The results showed that the intensity of fibrinogen deposition was positively correlated with eGFR (P < 0.001), serum albumin (P = 0.041), and hemoglobin levels (P < 0.05), but negatively correlated with age (P = 0.04), serum fibrinogen levels (P < 0.001), serum C4 (P = 0.023), the proportion of patients with hypertension (P = 0.003), and the percentage of glomeruli sclerosis (P < 0.001). The prognostic analyses identified that fibrinogen deposition was an independent predictor for the progression of IgAN (P = 0.033).

Conclusion
Our study indicated that the deposition of renal fibrinogen can predict the prognosis of IgAN with high reliability.
Groundwater vulnerability to pollution assessment: an application of geospatial techniques and integrated IRN-DEMATEL-ANP decision model
Authors: Chukwuma Emmanuel Chibundo , Okonkwo Chris Chukwuma , Afolabi Oluwasola Olakunle Daniel , Pham Quoc Bao , Anizoba Daniel Chinazom , Okpala Chikwunonso Divine 
Published: February 2023

Abstract
This study evaluated the susceptibility to groundwater pollution using a modified DRASTIC model. A novel hybrid multi-criteria decision-making (MCDM) model integrating Interval Rough Numbers (IRN), Decision Making Trial and Evaluation Laboratory (DEMATEL), and Analytical Network Process (ANP) was used to investigate the interrelationships between critical hydrogeologic factors (and determine their relative weights) via a novel vulnerability index based on the DRASTIC model. The flexibility of GIS in handling spatial data was employed to delineate thematic map layers of the hydrogeologic factors and to improve the DRASTIC model. The hybrid MCDM model results show that net recharge (a key hydrogeologic factor) had the highest priority with a weight of 0.1986. In contrast, the topography factor had the least priority, with a weight of 0.0497. A case study validated the hybrid model using Anambra State, Nigeria. The resultant vulnerability map shows that 12.98% of the study area falls into a very high vulnerability class, 31.90% falls into a high vulnerability, 23.52% falls into the average vulnerability, 21.75% falls into a low vulnerability, and 9.85% falls into very low vulnerability classes, respectively. In addition, nitrate concentration was used to evaluate the degree of groundwater pollution. Based on observed nitrate concentration, the modified DRASTIC model was validated and compared to the traditional DRASTIC model; interestingly, the spatial model of the modified DRASTIC model performed better. This study is thus critical for environmental monitoring and implementing appropriate management interventions to protect groundwater resources against indiscriminate sources of pollution.
The role of brain radiotherapy for EGFR- and ALK-positive non-small-cell lung cancer with brain metastases: a review
Authors: Nardone Valerio , Romeo Caterina , D’Ippolito Emma , Pastina Pierpaolo , D’Apolito Maria , Pirtoli Luigi , Caraglia Michele , Mutti Luciano , Bianco Giovanna , Falzea Antonella Consuelo , Giannicola Rocco , Giordano Antonio , Tagliaferri Pierosandro , Vinciguerra Claudia , Desideri Isacco , Loi Mauro , Reginelli Alfonso , Cappabianca Salvatore , Tassone Pierfrancesco , Correale Pierpaolo 
Published: February 2023

AbstractNon-small cell lung cancer (NSCLC) is frequently complicated by central nervous system (CNS) metastases affecting patients’ life expectancy and quality. At the present clinical trials including neurosurgery, radiotherapy (RT) and systemic treatments alone or in combination have provided controversial results. CNS involvement is even more frequent in NSCLC patients with EGFR activating mutations or ALK rearrangement suggesting a role of target therapy in the upfront treatment in place of loco-regionals treatments (i.e. RT and/or surgery). So far clinical research has not explored the potential role of accurate brain imaging (i.e. MRI instead of the routine total-body contrast CT and/or PET/CT staging) to identify patients that could benefit of local therapies. Moreover, for patients who require concomitant RT there are no clear guidelines on the timing of intervention with respect to innovative precision medicine approaches with Tyrosine Kinase Inhibitors, ALK-inhibitors and/or immuno-oncological therapies. On this basis the present review describes the therapeutic strategies integrating medical and radiation oncology in patients with metastatic NSCLC (mNSCLC) adenocarcinoma with CNS involvement and EGFR activating mutations or ALK rearrangement.
Aortic valve and vascular calcium score in pre-TAVI CT: correlation with early post-procedural complications
Authors: Milo Sabrina Maria , Toia Patrizia , Midiri Federico , D’Alessandro Luigi , Sollami Giulia , Panci Aldo , Pernice Vincenzo , Violante Francesco , Fattouch Khalil , Cutaia Giuseppe , Salvaggio Giuseppe , Lo Re Giuseppe , Grassedonio Emanuele , Galia Massimo , La Grutta Ludovico 
Published: February 2023

Abstract
Purpose
The aim of our study was to evaluate the prevalence of early complications after Transcatheter Aortic Valve Implantation (TAVI) and their correlation with the Calcium Score (CS) of the aortic valve, aorta and ilio-femoral arteries derived from pre-procedural computed tomography (CT).

Materials and methods
We retrospectively reviewed 226 patients (100 males, mean age 79.4 ± 6.7 years) undergoing 64-slice CT for pre-TAVI evaluation from January 2018 to April 2021. The population was divided into CS quartiles.

Results
Overall, 173 patients underwent TAVI procedure, of whom 61% presented paravalvular leak after the procedure, 28% presented bleeding or vascular complications, 25% presented atrioventricular block, and 8% developed acute kidney injury. The prevalence of paravalvular leak and vascular complications was higher in the upper CS quartiles for aortic valve and ilio-femoral arteries.

Conclusions
Aortic valve and vascular CS could help to predict post-TAVI early complications.
Advances in cumulative effects assessment and application in marine and coastal management
Authors: Willsteed Edward A. , New Leslie , Ansong Joseph O. , Hin Vincent , Searle Kate R. , Cook Aonghais S. C. P. 
Published: February 2023

Abstract
Quantifying and managing the cumulative effects of human activities on coastal and marine environments is among the foremost challenges in enabling sustainable development in the twenty-first century. As the speed with which these environments are changing increases, there is greater impetus to resolve the evident problems facing governance systems responsible for managing cumulative impacts. Policymakers and regulators recognise the need to assess and manage cumulative effects, as evidenced by widespread legislation requiring cumulative effects assessment (CEA). Yet there is ample evidence that we are not turning the tide in terms of balancing good environmental health with increasing demands of already degraded coastal and marine spaces that are increasingly impacted by climate change. This paper reviews the current state of knowledge regarding scientific and practical advances in CEA, assesses whether these advances are being applied in decision-making and identifies where challenges to implementation exist. Priority research questions are formulated to accelerate the inclusion of effective CEA in marine and coastal planning and management.
The Standard Picture and Statutory Interpretation
Authors: Graham Aaron 
Published: February 2023

AbstractThe Standard Picture holds that the contribution to the law made by an authoritative legal pronouncement is directly explained by the linguistic content of that pronouncement. This essay defends the Standard Picture from Mark Greenberg’s purported counterexamples drawn from patterns of statutory interpretation in U.S. criminal law. Once relevant features of the U.S. rule of recognition are admitted into the analysis—namely, that it arranges sources of law hierarchically, and that judicial decisions are sources of valid law—Greenberg’s counterexamples are revealed as only apparent, not genuine. The legal norms that result from the patterns of interpretation he identifies can be directly explained in terms of the linguistic contents of authoritative pronouncements: judicial decisions. Furthermore, those norms can be understood as modifications of the valid norms contained in their originating statutes because judicial decisions are permitted ‘explanatory intermediaries’ of statutes by the rule of recognition.
Developing Countries: The Legacy of Keynes and Post-Keynesian Economists
Authors: Bagchi Amiya Kumar 
Published: February 2023

AbstractGeoffrey Harcourt remained a steadfast left Keynesian all his life. He applied his economic analysis in framing policy recommendations targeting the welfare of the poor. He undertook incisive and comprehensive surveys of the work of Cambridge post-Keynesians, some of whom were involved intellectually or practically in the economics of developing economies. Keynes, remaining an imperialist as far as India was concerned, nevertheless produced a corpus which has been immensely helpful in understanding developing economies and prescribing policy solutions for them. First, Keynes created the modern macroeconomics discipline and refined the concept of national income, allowing methods of collecting and organising economic and social data enabling assessment of intersectoral impacts. Second, still relevant today is his idea of an International Clearing Union, disciplining countries with excessive balance of payments surpluses or deficits, even though American opposition at Bretton Woods prevented its adoption. Third, although an economist of the short run, Keynes took up issues of vital concern for the development of an underdeveloped economy, departing from his long-held fears about excessive population growth and contributing to policies for stabilising commodity prices. While Keynes remained a Eurocentric imperialist, his dreams for Europe in general and Britain in particular proved relevant for many developing countries today. He supported public investment and state involvement in solving problems of unemployment and industrial restructuring. His analysis of the instability of stock markets and dangers of financialisation remains highly relevant in a world experiencing major stock market crashes in almost every decade since the 1970s.
Principles of diagnostic stewardship: A practical guide from the Society for Healthcare Epidemiology of America Diagnostic Stewardship Task Force
Authors: Fabre Valeria , Davis Angelina , Diekema Daniel J. , Granwehr Bruno , Hayden Mary K. , Lowe Christopher F. , Pfeiffer Christopher D. , Sick-Samuels Anna C. , Sullivan Kaede V. , Van Schooneveld Trevor C. , Morgan Daniel J. 
Published: February 2023

Executive summaryWe provide an overview of diagnostic stewardship with key concepts that include the diagnostic pathway and the multiple points where interventions can be implemented, strategies for interventions, the importance of multidisciplinary collaboration, and key microbiologic diagnostic tests that should be considered for diagnostic stewardship. The document focuses on microbiologic laboratory testing for adult and pediatric patients and is intended for a target audience of healthcare workers involved in diagnostic stewardship interventions and all workers affected by any step of the diagnostic pathway (ie, ordering, collecting, processing, reporting, and interpreting results of a diagnostic test). This document was developed by the Society for Healthcare Epidemiology of America Diagnostic Stewardship Taskforce.
Pursuing Change or Pursuing Credit? Litigation and Credit Claiming on Social Media
Authors: Gunderson Anna , Widner Kirsten , Macdonald Maggie 
Published: February 2023

AbstractInterest groups often post about their judicial advocacy on social media. We argue that they do so for two main reasons. First, providing information about the courts on social media builds the group’s credibility as a source of information with policymakers, media and the public. Second, social media provides a way to claim credit for litigation activity and outcomes, which can increase membership and aid in fundraising. Using original datasets of millions of tweets and Facebook posts by interest groups, we provide evidence that interest groups use social media for public education and to credit claim for their litigation activity.
Mouth breathing, dry air, and low water permeation promote inflammation, and activate neural pathways, by osmotic stresses acting on airway lining mucus
Authors: Edwards David A. , Chung Kian Fan 
Published: February 2023

Abstract
Respiratory disease and breathing abnormalities worsen with dehydration of the upper airways. We find that humidification of inhaled air occurs by evaporation of water over mucus lining the upper airways in such a way as to deliver an osmotic force on mucus, displacing it towards the epithelium. This displacement thins the periciliary layer of water beneath mucus while thickening topical water that is partially condensed from humid air on exhalation. With the rapid mouth breathing of dry air, this condensation layer, not previously reported while common to transpiring hydrogels in nature, can deliver an osmotic compressive force of up to around 100 cm H2O on underlying cilia, promoting adenosine triphosphate secretion and activating neural pathways. We derive expressions for the evolution of the thickness of the condensation layer, and its impact on cough frequency, inflammatory marker secretion, cilia beat frequency and respiratory droplet generation. We compare our predictions with human clinical data from multiple published sources and highlight the damaging impact of mouth breathing, dry, dirty air and high minute volume on upper airway function. We predict the hypertonic (or hypotonic) saline mass required to reduce (or amplify) dysfunction by restoration (or deterioration) of the structure of ciliated and condensation water layers in the upper airways and compare these predictions with published human clinical data. Preserving water balance in the upper airways appears critical in light of contemporary respiratory health challenges posed by the breathing of dirty and dry air.
Application of the vortex breakdown phenomenon in the attenuation of trailing vortices
Authors: Traub L. W. , Mani S. , Galls S. F. , Rediniotis O. K. 
Published: February 2023

AbstractAn experimental investigation to determine the effectiveness of a wing-tip device designed to attenuate the trailing vortex of a lifting, flat-plate wing is detailed. The induced-breakdown vortex attenuation device (IBVAD) is essentially a toed-in, vertically-oriented sheared tip. Results are presented comprising force-balance, water tunnel flow visualisation and wake studies using a seven hole probe. The data shows that compared with an equal span rectangular wing, variations of the IBVAD device can reduce drag at moderate-to-high lift coefficients, as well as reduce die maximum rotary velocity of the trailing vortex by 28%. Axial vorticity in the wake vortex was significantly attenuated compared with the rectangular wing, with a 52·6% reduction in the magnitude of die maximum vorticity. The vortex core radius was also seen to be larger than die rectangular wing. However, even substantial attenuation and redistribution of trailing vorticity may be insufficient to reduce the wake hazard.
Unsteady propeller flows due to turbulence ingestion
Authors: Harden J. M. , Lowson M. V. 
Published: February 2023

AbstractA laser doppler anemometer (LDA) was configured to provide simultaneous ID velocity readings from two separate points in the contracting flow regime upstream of 0·63 m diameter model propeller operating under high thrust conditions. Cross-correlations between the velocity signals were used to map the progress of turbulent eddy structures throughout the distortion, even within the highly oscillatory region close to the blades. These measurements were used to provide data on the strength and velocity of the eddies, as well as their average size and shape in two dimensions. The results show both elongation of the turbulent structures in the streamwise direction and distortion along their length, caused by the contracting flow and the high Reynolds stress. Linearised isotropic theory was used to predict the changes in the turbulent kinetic energies, and was found to be accurate for the longitudinal component only.
Two new techniques for aircraft parameter estimation using neural networks
Authors: Raisinghani S. C. , Ghosh A. K. , Kalra P. K. 
Published: February 2023

AbstractTwo new techniques for estimating aircraft stability and control derivatives (parameters) from flight data using feed forward neural networks are proposed. Both techniques use motion variables and control inputs as the input file, while aerodynamic coefficients are presented as the output file for training a neural network. For the purpose of parameter estimation, the trained neural network is presented with a suitably modified input file, and the corresponding predicted output file of aerodynamic coefficients is obtained. Suitable interpretation and manipulation of such input-output files yields the estimated values of the parameters. The methods are validated first on the simulated flight data and then on real flight data obtained by digitising analogue data from a published report. Results are presented to show how the accuracy of the estimates is affected by the topology of the network, the number of iterations and the intensity of the measurement noise in simulated flight data. One of the significant features of the proposed methods is that they do not require guessing of a reasonable set of starting values of the parameters as a popular parameter estimator like the maximum likelihood method does.
Transonic flow over wavy walls: a new solution procedure compared with experiments
Authors: Narang B. S. , Ho J. 
Published: February 2023

AbstractA new method has been used to solve the transonic flow equation for flow over a wavy wall. The results thus obtained are compared with those obtained from windtunnel experiments. A new fluctuating flow phenomenon has been observed both in the experiment and in numerical calculations which may enhance flow mixing. The numerical results also indicate that the flow becomes locally sonic for a transonic parameter value greater than 0·5, while experimental data indicate a value of 0·6363 for the transonic parameter. The classical value of transonic parameter has a value of one for the flow to become locally sonic.