bluuebunny/crossref_metadata_2025_split huggingface dataset:
Various neuromodulation methods including Deep Brain Stimulation of the medial forebrain bundle combined with psychopharmacotherapy of treatment-resistant depression—Case report
Authors: Rymaszewska Joanna , Wieczorek Tomasz , Fila-Witecka Karolina , Smarzewska Katarzyna , Weiser Artur , Piotrowski Patryk , Tabakow Paweł 
Published: January 2023

BackgroundTreatment-resistant depression remains one of the main concerns of modern psychiatry. Novel methods such as Transcranial Magnetic Stimulation (including deep and theta burst protocols, iTBS) and Deep Brain Stimulation (DBS) can be considered as alternative treatment options.Case presentationTwenty-nine-year-old Caucasian female, single, higher-educated was treated with major depressive disorder initially with standard pharmaco- and psychotherapy. Due to diagnosed treatment resistance additional therapeutic approaches were introduced sequentially: Electroconvulsive therapy (efficient only 4 months) and Transcranial Magnetic Stimulation (intermittent Theta Burst Stimulation, iTBS improved just insomnia). Finally the patient was enrolled to the Deep Brain Stimulation (DBS) study with the medial forebrain bundle target. After 20 months of active DBS a reduction of over 80% of depressive symptom severity was observed (Montgomery-Asberg and Hamilton Depression Rating Scales), together with an 87% reduction of anxiety symptoms intensity (Hamilton Anxiety Rating Scale) and a 90% increase in social and occupational functioning. Subjective assessment of the patient performed with questionnaires and visual analog scales showed less pronounced improvement in terms of depressive and anxiety symptoms, and high reduction of anhedonia. Some mild, transient side effects of neurostimulation were eliminated with an adjustment in stimulation parameters.ConclusionsThe presented clinical case confirms the possibility of achieving remission after the use of MFB DBS in treatment-resistant depression, but postponed for many months. Nevertheless, personalization of every combined therapy with DBS is necessary with exploration of individual factors as past traumas and personality traits. More reports on long-term observations in DBS treatment in TRD trials (especially focused on MFB target) are needed.
A quantitative and qualitative examination of the impacts of the COVID-19 pandemic on U.S. veterans with self-reported anxiety and alcohol use disorder
Authors: Duarte Brooke A. , Kelly Megan M. , Shirk Steven D. , Chamberlin Elizabeth S. , Reilly Erin D. 
Published: January 2023

IntroductionThe COVID-19 pandemic generated concerns about rising stress and alcohol use, especially in U.S. veterans who experience high rates of anxiety disorders (ADs), alcohol use disorder (AUD), and dual AD+AUD diagnoses. This study investigated differences among these diagnostic groups in a veteran population related to their concern about COVID-19, impacts of COVID-19 on quality of life, and self-reported changes to urge to drink and drinking frequency.MethodsA nationally administered online survey was given to a sample of U.S. veterans reporting substance use issues during the pandemic. Differences in the level of concern about COVID-19, impacts of COVID-19 on quality of life, and drinking behaviors were examined in those self-reporting AD (n = 98), AUD (n = 46), or AD+AUD (n = 67). Consensual qualitative research was used to analyze an open-ended question about COVID-19’s impact on substance use, health, and quality of life.ResultsVeterans with AD+AUD experienced significant increases in urge to drink and alcohol consumption compared to veterans with AD only. Greater urge and frequency of drinking were associated with greater negative impacts of COVID-19 on quality of life. There were no differences among groups in global negative impact on quality of life or level of COVID-19 concern. However, respondents described specific COVID-19 worries, with qualitative findings revealing that those with AD+AUD reported a disproportionate psychosocial burden due to the pandemic.DiscussionSpecial attention in screening and treatment should be given to those with a dual AD+AUD diagnosis who may be experiencing both an increase in alcohol use and psychosocial burden as stress increases due to the pandemic.
Estimating the future global dose demand for measles–rubella microarray patches
Authors: Ko Melissa , Malvolti Stefano , Cherian Thomas , Mantel Carsten , Biellik Robin , Jarrahian Courtney , Menozzi-Arnaud Marion , Amorij Jean-Pierre , Christiansen Hans , Papania Mark J. , Meltzer Martin I. , Masresha Balcha Girma , Pastor Desiree , Durrheim David N. , Giersing Birgitte , Hasso-Agopsowicz Mateusz 
Published: January 2023

BackgroundProgress toward measles and rubella (MR) elimination has stagnated as countries are unable to reach the required 95% vaccine coverage. Microarray patches (MAPs) are anticipated to offer significant programmatic advantages to needle and syringe (N/S) presentation and increase MR vaccination coverage. A demand forecast analysis of the programmatic doses required (PDR) could accelerate MR-MAP development by informing the size and return of the investment required to manufacture MAPs.MethodsUnconstrained global MR-MAP demand for 2030–2040 was estimated for three scenarios, for groups of countries with similar characteristics (archetypes), and four types of uses of MR-MAPs (use cases). The base scenario 1 assumed that MR-MAPs would replace a share of MR doses delivered by N/S, and that MAPs can reach a proportion of previously unimmunised populations. Scenario 2 assumed that MR-MAPs would be piloted in selected countries in each region of the World Health Organization (WHO); and scenario 3 explored introduction of MR-MAPs earlier in countries with the lowest measles vaccine coverage and highest MR disease burden. We conducted sensitivity analyses to measure the impact of data uncertainty.ResultsFor the base scenario (1), the estimated global PDR for MR-MAPs was forecasted at 30 million doses in 2030 and increased to 220 million doses by 2040. Compared to scenario 1, scenario 2 resulted in an overall decrease in PDR of 18%, and scenario 3 resulted in a 21% increase in PDR between 2030 and 2040. Sensitivity analyses revealed that assumptions around the anticipated reach or coverage of MR-MAPs, particularly in the hard-to-reach and MOV populations, and the market penetration of MR-MAPs significantly impacted the estimated PDR.ConclusionsSignificant demand is expected for MR-MAPs between 2030 and 2040, however, efforts are required to address remaining data quality, uncertainties and gaps that underpin the assumptions in this analysis.
Trend of disease burden and risk factors of breast cancer in developing countries and territories, from 1990 to 2019: Results from the Global Burden of Disease Study 2019
Authors: Lv Linlin , Zhao Binggong , Kang Jie , Li Shujing , Wu Huijian 
Published: January 2023

BackgroundThe incidence, mortality, burden of disability-adjusted life years (DALYs), and attributable risk factors of breast cancer vary significantly by country or region, particularly between developing and developed countries. This study aimed to analyze breast cancer development trends in developing countries based on the influence of the different sociodemographic indices (SDIs) and World Bank (WB) income-level disease data from 1990 to 2019.MethodsData on the annual incidence, mortality, DALY, years of life lost (YLL) prematurely, years lived with disability (YLD), and age-standardized rate (ASR) of breast cancer from 1990 to 2019 in different countries and territories were obtained from the 2019 Global Burden of Disease (GBD) Study. A comparative risk assessment (CRA) framework was used to analyze the general risk factors.ResultsThe global age-standardized incidence rate (ASIR) gradually increased from 21.44 per 100,000 population in 1990 to 24.17 per 100,000 population in 2019. It rose precipitously to 2.91- and 2.49-fold, respectively, for countries with middle SDIs and low-middle SDIs. The ASIR of breast cancer was increasing in the lower-middle-income levels in WB, with an estimated annual percentage change (EAPC) of 0.29 [95% uncertainty interval (UI): 0.20–0.37] and reduced income (EAPC of 0.59 [95% UI: 0.53–0.65]). The Solomon Islands and the United Arab Emirates observed the most significant increase in the magnitude of deaths from breast cancer cases. Compared to the death cases of 1990, percentage changes increased separately by 1,169 and 851%. Compared to developed areas, breast cancer-related deaths increased rapidly in developing regions, especially among the middle-aged and elderly groups. Meanwhile, the long-term burden of breast cancer was ever expanding. Of all the GBD regions, Oceania had the youngest age distribution. The deaths in the young and middle-aged groups accounted for 69% in 1990 and 72% in 2019. Percentage changes in deaths from the seven risk factors in low- to middle-SDI regions increased significantly over time across all age groups. However, a diet with high red meat and high body mass index (BMI) accounted for the most considerable increase in the magnitude.ConclusionPublic health policy regarding breast cancer is fundamental in low- and medium-income countries. The development and adoption of cost-effective screening and therapeutic solutions, the mitigation of risk factors, and the establishment of a cancer infrastructure are essential.
Factors influencing the health satisfaction of users of public health and medical institutions in South Korea
Authors: Yoon Kichan , Lee Munjae 
Published: January 2023

IntroductionIn this study, we investigated the health satisfaction levels of users of regional health and medical institutions in South Korea and the influencing factors.MethodsWe included randomly selected 300 people with experience in using health and medical institutions from panel data targeting the entire nation. We used questionnaire (EQ-5D-5L) and sociodemographic characteristics to analyze the health satisfaction. EQ-5D-5L was used to measure health-related quality of life in five areas: mobility, self-management, daily activities, pain/discomfort, and anxiety/depression. Hierarchical linear regression analysis was performed in three steps to examine the factors influencing health satisfaction.ResultsThe analysis showed that the health satisfaction was positively (+) correlated with monthly income, mobility, self-management, daily life, pain/discomfort, and anxiety/depression, and negatively (−) correlated with the number of chronic diseases and type of health insurance. The influencing factors in Step 1 and 2 were chronic diseases (β = −0.380, −0.385), respectively. The influencing factors in Step 3 were pain/discomfort (β = 0.202), anxiety/depression (β = 0.257), and the number of chronic diseases (β = −0.222).DiscussionsThe current data suggested that regional health and medical institutions should focus their services on residents with chronic diseases. Moreover, they should expand physical activities to relieve physical pain or discomfort and provide services related to mental health. To accomplish these, we suggested that the government will need to promote post-service health checkup results as a key project, provide user-customized services, provide online services utilizing ICT, expanding the government's financial support, and building infrastructure.
Assessment of blood cultures and antibiotic susceptibility testing for bacterial sepsis diagnosis and utilization of results by clinicians in Benin: A qualitative study
Authors: Legba Brice Boris , Dougnon Victorien , Koudokpon Hornel , Mero Sointu , Elovainio Riku , Parry Matti , Bankole Honoré , Haukka Kaisa 
Published: January 2023

ObjectivesWe assessed the current status of blood culture and antibiotic susceptibility testing (AST) practices in clinical laboratories in Benin, and how the laboratory results are used by physicians to prescribe antibiotics.MethodsThe qualitative study covered twenty-five clinical laboratories with a bacteriology unit and associated hospitals and pharmacies. Altogether 159 laboratory staff, physicians and pharmacists were interviewed about their perceptions of the state of laboratory diagnostics related to sepsis and the use of antibiotics. Face-to-face interviews based on structured questionnaires were supported by direct observations when visiting five laboratories in across the country.ResultsOnly 6 laboratories (24%) conducted blood cultures, half of them with a maximum of 10 samples per month. The most common gram-negative bacteria isolated from blood cultures were: Escherichia coli, Salmonella spp. and Salmonella enterica serovar Typhi while the most common gram-positives were Enterococcus spp. and Staphylococcus aureus. None of the laboratories listed Klebsiella pneumoniae among the three most common bacteria isolated from blood cultures, although other evidence indicates that it is the most common cause of sepsis in Benin. Due to limited testing capacity, physicians most commonly use empirical antibiotic therapy.ConclusionsMore resources are needed to develop laboratory testing capacity, technical skills in bacterial identification, AST, quality assurance, and communication of results must be strengthened.
Patient satisfaction with nurses' care is positively related to the nurse–patient relationship in Chinese hospitals: A multicentre study
Authors: Guo Shujie , Chang Yulan , Chang Hongwei , He Xiaoxiao , Zhang Qiuxue , Song Baoyun , Liu Yilan 
Published: January 2023

BackgroundThe nurse–patient relationship and nursing care satisfaction are important factors that represent whether patients experience the care they expect from nurses. However, research is lacking on the relationship between nursing staff and patients, and the correlation between nursing care satisfaction and relationship care in China. Therefore, this study aimed to explore the correlation between the nurse–patient relationship and patients' satisfaction with nursing care, to form a basis for corresponding intervention measures.MethodsA total of 29,108 patients from 107 hospitals in 30 provinces/municipalities in China completed a general information questionnaire, the Nursing Care Satisfaction Scale, and Relational Care Scale.ResultsThe average nurse–patient relational care scale score was 4.38 ± 0.57, and the average patients' satisfaction with nursing care scale score was 5.40 ± 0.86. Nursing care satisfaction score was significantly related to differences among patients in different age, gender, marital status, education level, occupation, residence, family per capita monthly income, type of medical insurance, medical department, and regional patient characteristics. The correlation analysis showed that the total nurse–patient relational care score and its three dimensions of caring, trust, and professional ethics correlated positively with nursing care satisfaction scores. The multiple linear regression analysis showed that patients' age, marital status, region, department, income, type of medical insurance and the caring, trust, and professional ethics dimensions of relational care predicted nursing care satisfaction.ConclusionEnhancing nurse–patient relational care improves nursing care satisfaction, reduces nurse–patient disputes, promotes early rehabilitation of patients, and ensures patient safety.
Associations between neighborhood walkability and walking following residential relocation: Findings from Alberta's Tomorrow Project
Authors: McCormack Gavin R. , Koohsari Mohammad Javad , Vena Jennifer E. , Oka Koichiro , Nakaya Tomoki , Chapman Jonathan , Martinson Ryan , Matsalla Graham 
Published: January 2023

IntroductionCross-sectional studies consistently find that the neighborhood built environment (e.g., walkability) is associated with walking. However, findings from the few existing longitudinal residential relocation studies that have estimated associations between changes in neighborhood built characteristics and walking are equivocal. The study objective was to estimate whether changes in neighborhood walkability resulting from residential relocation were associated with leisure, transportation, and total walking levels among adults.MethodsThis study included longitudinal data from the “Alberta's Tomorrow Project”—a province-wide cohort study (Alberta, Canada). The analysis included data collected at two time points (i.e., baseline and follow-up) from 5,977 urban adults. The International Physical Activity Questionnaire (IPAQ) captured self-reported walking. We estimated neighborhood walkability, an index capturing intersection, destination, and population counts for the 400 m Euclidean buffer around participants' homes. Using household postal codes reported at baseline and follow-up, we categorized participants into three groups reflecting residential relocation (“non-movers:” n = 5,679; “movers to less walkability:” n = 164, and; “movers to more walkability:” n = 134). We used Inverse-Probability-Weighted Regression Adjustment to estimate differences [i.e., average treatment effects in the treated (ATET)] in weekly minutes of leisure, transportation, and total walking at follow-up between residential relocation groups, adjusting for baseline walking, sociodemographic characteristics, and walkability. The median time between baseline and follow-up was 2-years.ResultsThe three residential relocation groups mainly included women (61.6–67.2%) and had a mean age of between 52.2 and 55.7 years. Compared to “non-movers” (reference group), weekly minutes of transportation walking at follow-up was significantly lower among adults who moved to less walkable neighborhoods (ATET: −41.34, 95 CI: −68.30, −14.39; p &lt; 0.01). We found no other statistically significant differences in walking between the groups.DiscussionOur findings suggest that relocating to less walkable neighborhoods could have detrimental effects on transportation walking to the extent of adversely affecting health. Public health strategies that counteract the negative impacts of low walkable neighborhoods and leverage the supportiveness of high walkable neighborhoods might promote more walking.
Perspectives on learning to practice reflexivity while engaging communities in implementation science
Authors: Woodward Eva N. , Ball Irenia A. 
Published: January 2023

BackgroundAs implementation scientists and practitioners engage community members and service users, reflexivity rises as a critical approach for managing power imbalances and effective collaborative work to promote equity. Reflexivity is an approach for acknowledging scientists’ own positions, including their understanding and limits of how they view their phenomena of inquiry. We describe our perspective practicing reflexivity as an implementation science team new to community engagement.MethodsWe spent over two years learning principles of Community-Based Participatory Research (CBPR) to inform implementation science and practice, then applied CPBR principles into a new community-academic partnership in August 2020 for and with veterans of the United States Military living in rural Arkansas. We used five methods to practice reflexivity for the first time: identifying positionality, writing fieldnotes, obtaining mentorship on technical aspects, comparing head notes, and consulting reference materials.DiscussionWe found multiple methods for practicing reflexivity to be feasible, although difficult to stay consistent with busy schedules. Fieldnotes especially required commitment and were important not to minimize. Written fieldnotes enabled us to reflect on successes and missteps, funneling into action planning. Head notes allowed emotional catharsis and to generate insights based on each other's perspectives. Referencing books or course modules reminded us of ideal CBPR principles. Discussion with mentors helped us with technical aspects and balancing real-world challenges with ideal CBPR principles. Our methods to practice reflexivity were valuable and directly impacted process and research outcomes. Future training for implementation science and practice might consider reflexivity practice as a core competency.
Assessment of the arrival signatures of the March 2012 CME–CME interaction event with respect to Mercury, Venus, Earth, STEREO-B, and Mars locations
Authors: Soni Shirsh Lata , Selvakumaran R. , Thampi R. Satheesh 
Published: January 2023

In March 2012, favorable positions of Mercury, Venus, Earth, Mars, and STEREO-B in the inner Solar System provided an opportunity to understand the global structure and the propagation of two coronal mass ejections (CMEs) across the inner Solar System. On 7 March 2012, the Sun ejected two very fast CMEs from the solar active region NOAA AR11489, which were accompanied by two X-class flares. Initialization and subsequent fast expansion from lower coronal heights of flux rope structures were detected as their early eruption signatures in Solar Dynamics Observatory (SDO) observations. White-light observations have been imaged using SOHO/LASCO and STEREO/SECCHI/COR2 and followed from 00:24 UT on 7 March 2012. We examined the kinematics of the reported CMEs and found a significant exchange of momentum and kinetic energy during the interaction, indicating that the collision was almost inelastic. Furthermore, we observed the arrival of this merged CME event at different distances in the inner Solar System and compared the arrival time with other models. The reported event arrived on Mercury at 04:30 UT; Venus, at 13:28 UT on 7 March 2012; and it took roughly 36 h to reach STEREO-B on 08 March, 03:36 UT. The arrivals at Mercury and Venus are observed in the magnetometer measurements onboard MESSENGER and Venus Express (VEx), respectively. A powerful interplanetary shock was observed on 08 March, 10:19 UT at Earth around 30 h after the two X-class flares and CMEs’ eruption. Subsequently, a south-directed interplanetary magnetic field (IMF) was observed on Earth, indicating the arrival of an interplanetary coronal mass ejection (ICME). This event caused the sudden storm commencement and development of one of the major intense geomagnetic storms of SC 24, with a minimum Dst value of −148 nT. The observations by the Mars Express (MEX) mission indicated the arrival of a merged CME ∼2.5 days after its initial observation at Sun. We have analyzed the evolution of these CMEs and their propagation in the inner heliosphere and arrival signatures at four planetary locations. The propagation and arrival signatures are compared to simulations using the WSA-ENLIL + Cone model and the drag-based model at various vantage points. The study showcases the importance of multi-vantage point observations in understanding the propagation of CMEs and their interactions.