bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collecting–Gathering Biophysics of the BlackwormLumbriculus variegatus
Authors: Tuazon Harry , Nguyen Chantal , Kaufman Emily , Tiwari Ishant , Bermudez Jessica , Chudasama Darshan , Peleg Orit , Bhamla M Saad 
Published: June 2023

SynopsisMany organisms exhibit collecting and gathering behaviors as a foraging and survival method. Benthic macroinvertebrates are classified as collector–gatherers due to their collection of particulate matter. Among these, the aquatic oligochaete Lumbriculus variegatus (California blackworms) demonstrates the ability to ingest both organic and inorganic materials, including microplastics. However, earlier studies have only qualitatively described their collecting behaviors for such materials. The mechanism by which blackworms consolidate discrete particles into a larger clump remains unexplored quantitatively. In this study, we analyze a group of blackworms in a large arena with an aqueous algae solution (organic particles) and find that their relative collecting efficiency is proportional to population size. We found that doubling the population size (N = 25–N = 50) results in a decrease in time to reach consolidation by more than half. Microscopic examination of individual blackworms reveals that both algae and microplastics physically adhere to the worm’s body and form clumps due to external mucus secretions by the worms. Our observations also indicate that this clumping behavior reduces the worm’s exploration of its environment, possibly due to thigmotaxis. To validate these observed biophysical mechanisms, we create an active polymer model of a worm moving in a field of particulate debris. We simulate its adhesive nature by implementing a short-range attraction between the worm and the nearest surrounding particles. Our findings indicate an increase in gathering efficiency when we add an attractive force between particles, simulating the worm’s mucosal secretions. Our work provides a detailed understanding of the complex mechanisms underlying the collecting–gathering behavior in L. variegatus, informing the design of bioinspired synthetic collector systems, and advances our understanding of the ecological impacts of microplastics on benthic invertebrates.
Beliefs About Collective Responsibility for Educational Equity and Attitudes Toward Public Assistance to Students Experiencing Socioeconomic Disadvantage
Authors: Lee Jung-Sook , Lee Jihyun 
Published: June 2023

Abstract
Neoliberal educational reforms that emphasize market-based competition and individual responsibility have exacerbated socioeconomic segregation in the Australian school system, thereby putting underprivileged students at a greater disadvantage. This necessitates a renewed focus on educational equity. As the public’s policy preferences are important in policymaking, it is essential to understand the factors that contribute to the public’s attitudes toward equity-oriented educational policies. In this study, we investigated beliefs about collective responsibility as a contributing factor. An online survey of adults (N = 1,999) conducted in the most populous state in Australia revealed that people’s beliefs about collective responsibility for socioeconomic achievement gaps positively predicted their support for public assistance to students and schools in need. Furthermore, people’s appraisals of educational equity positively predicted their support for public assistance, partly due to its positive effects on those beliefs about collective responsibility. These results provide insight into ways to shape the public’s attitudes toward equity-oriented educational policies.
The good, the bad, and the ugly of US antitrust
Authors: Stucke Maurice E 
Published: June 2023

Abstract
This article examines the bad and ugly as the US federal agencies seek to rejuvenate competition. The bad is legislative hiatus to update the antitrust laws for the digital economy. The ugly is when courts push their own economic beliefs, without regard for the congressional intent and aims of the antitrust laws. Regardless of who wins, the rule of law (and those most dependent on the antitrust law) suffer. To correct America's market power problem, the article proposes restoring the constitutional balance, where the courts adjudicate, the legislature legislates, and enforcers enforce.
The water flea Moina macrocopa () (Cladocera: Daphniidae) withstands 100,000 × g in a centrifuge for 10 minutes
Authors: Ito Takafumi 
Published: June 2023

Abstract
The water flea Moina macrocopa (Straus, 1820) survived and did not become pelleted when centrifuged at 21,500 × g for 10 minutes. Five out of six individuals tested swam in the microtube after being centrifuged at 100,000 × g for 10 minutes. It was confirmed that M. macrocopa occurred near the bottom of a 15 ml centrifuge tube on the spoke of a bicycle wheel due to the centrifugal force of 5 × g. This results suggests that M. macrocopa would have withstood conditions of 100,000 × g at the bottom of the tube. This is the first report that a crustacean can withstand extremely high gravitational forces, which prompts the potential use of M. macrocopa as a new model for extreme hypergravity.
HBWO-JS: jellyfish search boosted hybrid beluga whale optimization algorithm for engineering applications
Authors: Yuan Xinguang , Hu Gang , Zhong Jingyu , Wei Guo 
Published: June 2023

Abstract
Beluga whale optimization (BWO) algorithm is a recently proposed population intelligence algorithm. Inspired by the swimming, foraging, and whale falling behaviors of beluga whale populations, it shows good competitive performance compared to other state-of-the-art algorithms. However, the original BWO faces the challenges of unbalanced exploration and exploitation, premature stagnation of iterations, and low convergence accuracy in high-dimensional complex applications. Aiming at these challenges, a hybrid BWO based on the jellyfish search optimizer (HBWO-JS), which combines the vertical crossover operator and Gaussian variation strategy with a fusion of jellyfish search (JS) optimizer, is developed for solving global optimization in this paper. First, the BWO algorithm is fused with the JS optimizer to improve the problem that BWO tends to fall into the best local solution and low convergence accuracy in the exploitation stage through multi-stage exploration and collaborative exploitation. Then, the introduced vertical cross operator solves the problem of unbalanced exploration and exploitation processes by normalizing the upper and lower bounds of two stochastic dimensions of the search agent, thus further improving the overall optimization capability. In addition, the introduced Gaussian variation strategy forces the agent to explore the minimum neighborhood, extending the entire iterative search process and thus alleviating the problem of premature stagnation of the algorithm. Finally, the superiority of the proposed HBWO-JS is verified in detail by comparing it with basic BWO and eight state-of-the-art algorithms on the CEC2019 and CEC2020 test suites, respectively. Also, the scalability of HBWO-JS is evaluated in three dimensions (10D, 30D, 50D), and the results show the stable performance of the proposed algorithm in terms of dimensional scalability. In addition, three practical engineering designs and two Truss topology optimization problems demonstrate the practicality of HBWO-JS. The optimization results show that HBWO-JS has a strong competitive ability and broad application prospects.
Abortion, Impairment, and Well-Being
Authors: Gillham Alex R 
Published: June 2023

Abstract
Hendricks’ The Impairment Argument (TIA) claims that it is immoral to impair a fetus by causing it to have fetal alcohol syndrome (FAS). Since aborting a fetus impairs it to a greater degree than causing it to have FAS, then abortion is also immoral. In this article, I argue that TIA ought to be rejected. This is because TIA can only succeed if it explains why causing an organism to have FAS impairs it to a morally objectionable degree, entails that abortion impairs an organism to a morally objectionable and greater degree than causing FAS, and satisfies The Impairment Principle’s ceteris paribus clause. In order to do all three things, TIA must presuppose some theory of well-being. Even then, no theory of well-being accomplishes all three tasks that TIA must in order to succeed. However, even if this is false and TIA can meet all three objectives by presupposing some theory of well-being, it would not do very much to advance the debate about the morality of abortion. As I argue, TIA would essentially restate well-established arguments against abortion based on whatever theory of well-being it must presuppose in order to be successful.
Geraniol suppresses tumour growth and enhances chemosensitivity of 5-fluorouracil on breast carcinoma in mice: involvement of miR-21/PTEN signalling
Authors: El-Ganainy Samar O , Shehata Asmaa M , El-Mallah Ahmed , Abdallah Dina , Mohy El-Din Mahmoud M 
Published: June 2023

Abstract

Objectives
Breast cancer is the most diagnosed cancer in females worldwide. Phytochemicals are among the recent compelling approaches showing anticancer activity. Geraniol is a monoterpenoid showing anti-tumoral potential in cell lines. However, its exact mechanism in breast cancer has not been elucidated. In addition, the possible chemosenstizing effect of geraniol when combined with chemotherapeutic drugs in breast carcinoma has not been previously addressed.

Methods
Therefore, the aim of the current work is to investigate the potential therapeutic as well as chemosensitizing effects of geraniol on breast carcinoma induced in mice through examination of tumour biomarkers and histopathology profile.

Key findings
Results showed a prominent suppression of tumour growth following geraniol treatment. This was accompanied with miR-21 downregulation that subsequently upregulated PTEN and suppressed mTOR levels. Geraniol was also able to activate apoptosis and inhibit autophagy. Histopathological examination revealed high necrosis areas separating malignant cells in the geraniol-treated group. Combined geraniol and 5-fluorouracil treatment induced more than 82% inhibition of tumour rate, surpassing the effect of each drug alone.

Conclusions
It can be concluded that geraniol could represent a promising avenue for breast cancer treatment as well as a potential sensitizing agent when combined with chemotherapeutic drugs.
Intraosseous extension of supraspinatus calcific tendonitis in a young patient with severe shoulder pain: a rare case report
Authors: Albishi Waleed , Alaseem Abdulrahman , Aljasser Sarah , Almohideb Faten , Almalki Mamdouh , AlFaleh Ahmed F 
Published: June 2023

Abstract
Calcific tendinopathy is one of the causes of shoulder pain and limited range of motion when it affects the rotator cuff tendons. Complications of such a condition are rare and include intraosseous and intramuscular migration. Calcific tendonitis can be classified as acute, subacute or chronic based on the onset of symptoms. The incidence of calcific tendonitis affects females more than males, with the median age of onset being between 40 and 60 years old. Diagnostic modalities include radiographs and computed tomography (CT); however, these are suboptimal when compared to the sensitivity of magnetic resonance imaging. Ninety percent of these cases are treated non-surgically. We present a rare case of a young female patient with right shoulder pain and limited range of motion secondary to the intraosseous migration of calcific tendonitis. The patient’s symptoms were resolved after a CT-guided percutaneous bone biopsy of the lesion. Clinical correlation with the aid of imaging and histopathology is a multimodal approach to help diagnose and treat such conditions.
Metabolic reprogramming in inflammaging and aging in T cells
Authors: Bevilacqua Alessio , Ho Ping-Chih , Franco Fabien 
Published: June 2023

Abstract
Aging represents an emerging challenge for public health due to the declined immune responses against pathogens, weakened vaccination efficacy, and disturbed tissue homeostasis. Metabolic alterations in cellular and systemic levels are also known to be cardinal features of aging. Moreover, cellular metabolism has emerged to provide regulations to guide immune cell behavior via modulations on signaling cascades and epigenetic landscape, and the aberrant aging process in immune cells can lead to inflammaging, a chronic and low-grade inflammation that facilitates aging by perturbing homeostasis in tissues and organs. Here, we review how the metabolic program in T cells is influenced by the aging process and how aged T cells modulate inflammaging. In addition, we discuss the potential approaches to reverse or ameliorate aging by rewiring the metabolic programming of immune cells.
Observational signatures of carbon–oxygen white dwarf merger remnants
Authors: Yao Philippe Z , Quataert Eliot , Goulding Andy 
Published: June 2023

ABSTRACT
Many double white dwarf (WD) mergers likely do not lead to a prompt thermonuclear explosion. We investigate the prospects for observationally detecting the surviving remnants of such mergers, focusing on the case of mergers of double Carbon–Oxygen WDs. For ∼104 yr, the merger remnant is observationally similar to an extreme AGB star evolving to become a massive WD. Identifying merger remnants is thus easiest in galaxies with high-stellar masses (high WD merger rate) and low star formation rates (low birth rate of ∼6–10 M⊙ stars). Photometrically identifying merger remnants is challenging even in these cases because the merger remnants appear similar to He stars and post-outburst classical novae. We propose that the most promising technique for discovering WD merger remnants is through their unusual surrounding photoionized nebulae. We use CLOUDY photoionization calculations to investigate their unique spectral features. Merger remnants should produce weak hydrogen lines, strong carbon and oxygen recombination, and fine-structure lines in the UV, optical and IR. With narrow-band imaging or integral field spectrographs, we predict that multiple candidates are detectable in the bulge of M31, the outskirts of M87 and other nearby massive galaxies, and the Milky Way. Our models roughly reproduce the WISE nebula surrounding the Galactic WD merger candidate IRAS 00500+6713; we predict detectable [Ne vi] and [Mg vii] lines with JWST but that the mid-IR WISE emission is dominated by dust not fine-structure lines.
Parameters of 220 million stars from Gaia BP/RP spectra
Authors: Zhang Xiangyu , Green Gregory M , Rix Hans-Walter 
Published: June 2023

ABSTRACT
We develop, validate and apply a forward model to estimate stellar atmospheric parameters (Teff, log g, and [Fe/H]), revised distances and extinctions for 220 million stars with XP spectra from Gaia DR3. Instead of using ab initio stellar models, we develop a data-driven model of Gaia XP spectra as a function of the stellar parameters, with a few straightforward built-in physical assumptions. We train our model on stellar atmospheric parameters from the LAMOST survey, which provides broad coverage of different spectral types. We model the Gaia XP spectra with all of their covariances, augmented by 2MASS and WISE photometry that greatly reduces degeneracies between stellar parameters, yielding more precise determinations of temperature and dust reddening. Taken together, our approach overcomes a number of important limitations that the astrophysical parameters released in Gaia DR3 faced, and exploits the full information content of the data. We provide the resulting catalogue of stellar atmospheric parameters, revised parallaxes, and extinction estimates, with all their uncertainties. The modelling procedure also produces an estimate of the optical extinction curve at the spectral resolution of the XP spectra (R ∼ 20–100), which agrees reasonably well with the R(V) = 3.1 CCM model. Remaining limitations that will be addressed in future work are that the model assumes a universal extinction law, ignores binary stars and does not cover all parts of the Hertzsprung–Russell Diagram (e.g. white dwarfs).
Modelling simultaneous CoRoT and Spitzer light curves: the impact of bending waves in the inner disc
Authors: Nagel E , Bouvier J 
Published: June 2023

ABSTRACT
We present a physical interpretation of the amplitude of light curves of young stellar objects (YSOs) simultaneously observed in the infrared with the Spitzer Space Telescope and in the optical with the CoRoT satellite. The modelled objects come from a sample of YSOs in the star forming region NGC 2264, and we focus on a subsample showing periodic dips in their CoRoT light curves. The model includes emission and stellar occultation caused by a warp at the inner edge of the disc. In order to fit the observed fluxes, we add a contribution coming from the inner disc. We find that the disc flux signal has the same periodicity as the stellar rotation, with a phase offset between the stellar and the disc signal of half the period, that is, the peak of the former coincides with the minimum of the latter. This behaviour is consistent with MHD simulations where a bending wave appears opposite to the warp formed at the base of the magnetospheric stream, which is rotating with the stellar rotation period. This evidence highlights the importance of infrared observations to complement the information extracted from optical light curves to be able to characterize structures at the inner disc.
ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex
Authors: Fu Jianfeng , Zhou Siru , Xu Huilin , Liao Liming , Shen Hui , Du Peng , Zheng Xiaofeng 
Published: June 2023

Abstract
53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here, we identified acetyltransferase ESCO2 as a regulator for DSB-induced cohesin-dependent chromatin structure dynamics, which promotes 53BP1 recruitment. Mechanistically, in response to DNA damage, ATM phosphorylates ESCO2 S196 and T233. MDC1 recognizes phosphorylated ESCO2 and recruits ESCO2 to DSB sites. ESCO2-mediated acetylation of SMC3 stabilizes cohesin complex conformation and regulates the chromatin structure at DSB breaks, which is essential for the recruitment of 53BP1 and the formation of 53BP1 microdomains. Furthermore, depletion of ESCO2 in both colorectal cancer cells and xenografted nude mice sensitizes cancer cells to chemotherapeutic drugs. Collectively, our results reveal a molecular mechanism for the ATM–ESCO2–SMC3 axis in DSB repair and genome integrity maintenance with a vital role in chemotherapy response in colorectal cancer.
Simultaneous measurement of nascent transcriptome and translatome using 4-thiouridine metabolic RNA labeling and translating ribosome affinity purification
Authors: Imai Hirotatsu , Utsumi Daisuke , Torihara Hidetsugu , Takahashi Kenzo , Kuroyanagi Hidehito , Yamashita Akio 
Published: June 2023

Abstract
Regulation of gene expression in response to various biological processes, including extracellular stimulation and environmental adaptation requires nascent RNA synthesis and translation. Analysis of the coordinated regulation of dynamic RNA synthesis and translation is required to determine functional protein production. However, reliable methods for the simultaneous measurement of nascent RNA synthesis and translation at the gene level are limited. Here, we developed a novel method for the simultaneous assessment of nascent RNA synthesis and translation by combining 4-thiouridine (4sU) metabolic RNA labeling and translating ribosome affinity purification (TRAP) using a monoclonal antibody against evolutionarily conserved ribosomal P-stalk proteins. The P-stalk-mediated TRAP (P-TRAP) technique recovered endogenous translating ribosomes, allowing easy translatome analysis of various eukaryotes. We validated this method in mammalian cells by demonstrating that acute unfolded protein response (UPR) in the endoplasmic reticulum (ER) induces dynamic reprogramming of nascent RNA synthesis and translation. Our nascent P-TRAP (nP-TRAP) method may serve as a simple and powerful tool for analyzing the coordinated regulation of transcription and translation of individual genes in various eukaryotes.
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR
Authors: Freda Ida , Exertier Cécile , Barile Anna , Chaves-Sanjuan Antonio , Vega Mirella Vivoli , Isupov Michail N , Harmer Nicholas J , Gugole Elena , Swuec Paolo , Bolognesi Martino , Scipioni Anita , Savino Carmelinda , Di Salvo Martino Luigi , Contestabile Roberto , Vallone Beatrice , Tramonti Angela , Montemiglio Linda Celeste 
Published: June 2023

Abstract
Specificity in protein–DNA recognition arises from the synergy of several factors that stem from the structural and chemical signatures encoded within the targeted DNA molecule. Here, we deciphered the nature of the interactions driving DNA recognition and binding by the bacterial transcription factor PdxR, a member of the MocR family responsible for the regulation of pyridoxal 5′-phosphate (PLP) biosynthesis. Single particle cryo-EM performed on the PLP-PdxR bound to its target DNA enabled the isolation of three conformers of the complex, which may be considered as snapshots of the binding process. Moreover, the resolution of an apo-PdxR crystallographic structure provided a detailed description of the transition of the effector domain to the holo-PdxR form triggered by the binding of the PLP effector molecule. Binding analyses of mutated DNA sequences using both wild type and PdxR variants revealed a central role of electrostatic interactions and of the intrinsic asymmetric bending of the DNA in allosterically guiding the holo-PdxR–DNA recognition process, from the first encounter through the fully bound state. Our results detail the structure and dynamics of the PdxR–DNA complex, clarifying the mechanism governing the DNA-binding mode of the holo-PdxR and the regulation features of the MocR family of transcription factors.
Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation
Authors: Cuadrat Rafael R C , Kratzer Adelheid , Arnal Hector Giral , Rathgeber Anja C , Wreczycka Katarzyna , Blume Alexander , Gündüz Irem B , Ebenal Veronika , Mauno Tiina , Osberg Brendan , Moobed Minoo , Hartung Johannes , Jakobs Kai , Seppelt Claudio , Meteva Denitsa , Haghikia Arash , Leistner David M , Landmesser Ulf , Akalin Altuna 
Published: June 2023

Abstract
Acute coronary syndrome (ACS) remains a major cause of worldwide mortality. The syndrome occurs when blood flow to the heart muscle is decreased or blocked, causing muscle tissues to die or malfunction. There are three main types of ACS: Non-ST-elevation myocardial infarction, ST-elevation myocardial infarction, and unstable angina. The treatment depends on the type of ACS, and this is decided by a combination of clinical findings, such as electrocardiogram and plasma biomarkers. Circulating cell-free DNA (ccfDNA) is proposed as an additional marker for ACS since the damaged tissues can release DNA to the bloodstream. We used ccfDNA methylation profiles for differentiating between the ACS types and provided computational tools to repeat similar analysis for other diseases. We leveraged cell type specificity of DNA methylation to deconvolute the ccfDNA cell types of origin and to find methylation-based biomarkers that stratify patients. We identified hundreds of methylation markers associated with ACS types and validated them in an independent cohort. Many such markers were associated with genes involved in cardiovascular conditions and inflammation. ccfDNA methylation showed promise as a non-invasive diagnostic for acute coronary events. These methods are not limited to acute events, and may be used for chronic cardiovascular diseases as well.