bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the fault slip rule and the rockburst mechanism induced by mining the panel through fault
Authors: Kong Peng , Wang Changxiang , Xing Luyi , Liang Min , He Jin 
Published: August 2023

Abstract
When mining operations are conducted near faults can cause the fault to slip and release energy, resulting in a rock burst and posing a significant safety risk to coal mine production. This paper proposes a numerical simulation method, based on FLAC3D numerical simulation, for calculating the dynamic forces of fault slippage below the impact of mining. The release patterns of energy from fault slip are compared and analyzed between mining across the fault from the hanging wall and mining across the fault from the footwall. The dynamic response characteristics of the mining area under the disturbance of fault slip-induced loading are revealed. This research suggests that the fault slip seismic second (M0) of the panel mined via the fault from the footwall is substantially higher thru from striking wall. Moreover, the disturbance of the footwall mining face across the fault leads to a more severe disturbance of the surrounding rock mass, resulting in a higher risk of dynamic pressure. Plastic failure of the rock surrounded in the mining area under the strong dynamic loading of fault slip leads to a significant reduction in peak abutment stress, releasing tremendous energy. When the disturbance caused by fault slip-induced loading is relatively small, the maximum abutment tension increases, and the dynamic load increases the energy storage of stope surrounding rock. Based on energy theory, an energy criterion for the occurrence of fault slip-type rockburst has been proposed. The results suggest that strong fault slip dynamic load has an obvious inducing effect on rock burst, and the stronger the dynamic load and greater static load of the rock surrounding the stope, the more the manifestation of rockburst.
Radiomics Based on Contrast-enhanced CT for Recognizing c-Met-Positive Hepatocellular Carcinoma: a Noninvasive Approach to Predict the Outcome of Sorafenib Resistance
Authors: gu jingxiao , bao shanlei , Akemuhan Reaoxian , jia zhongzheng , zhang yu , huang chen 
Published: August 2023

Abstract
Objectives
The purpose of our project was to investigate the effectiveness of radiomic features based on contrast-enhanced CT that can detect the expression of c-Met in hepatocellular carcinoma (HCC) and to validate its efficacy in predicting the outcome of sorafenib resistance.
Materials and Methods
In total, 130 patients (median age, 60 years) with pathologically confirmed HCC who underwent contrast material–enhanced CT from October 2012 to July 2020 were randomly divided into a training set (n = 91) and a test set (n = 39). Radiomic features were extracted from arterial phase (AP), portal venous phase (VP) and delayed phase (DP) images of every participant’s enhanced CT images.
Results
The entire group comprised 39 Met-positive and 91 Met-negative patients. The combined model, which included the clinical factors and the radiomic features, performed well in the training (area under the curve [AUC] = 0.878) and validation (AUC = 0.851) cohorts. The nomogram, which relied on the combined model, fit well in the calibration curves. Decision curve analysis (DCA) further confirmed that the clinical valuation of the nomogram achieved comparable accuracy in c-Met prediction. Among another 20 patients with HCC who had received sorafenib, the predicted high-risk group had shorter overall survival (OS) than the predicted low-risk group (p < 0.05).
Conclusion
A multivariate model acquired from three phases (AP, VP and DP) of enhanced CT, HBV-DNA, and GGT-II could be considered a satisfactory preoperative marker of the expression of c-Met in patients with HCC. This approach may help in overcoming sorafenib resistance in advanced HCC.
Efficacy and safety of gemcitabine plus nab-paclitaxel combination chemotherapy in patients with advanced pancreatic cancer refractory to gemcitabine monotherapy
Authors: Nishioka Mariko , Okano Naohiro , Wakabayashi Masashi , Ikeno Takashi , Hayashi Masato , Mizutani Tomonori , Nagashima Fumio , Furuse Junji 
Published: August 2023

Abstract
Background: This study aimed to investigate the efficacy and safety of gemcitabine (GEM) plus nab-paclitaxel (nab-PTX): (GnP), which remain unknown, in patients with advanced pancreatic cancer (PC) who showed good tolerance to GEM monotherapy prior to being refractory to it.
Methods:We retrospectively analyzed the data ofpatients with locally advanced or metastatic PC who received GEM followed by GnP between December 2014 and March 2019, regardless of the treatment line.
Results:A total of 14 patients who received GnP after becoming refractory to GEM were included in this study. Eight patients were included in the nab-PTX naïve group: seven of whom were treated with GEM monotherapy as first-line chemotherapy and one was refractory to GEM monotherapy after modified FOLFIRINOX treatment. The other six patients were included in the nab-PTX reintroduction group. In this group, all patients received GnP followed by GEM maintenance therapy to prevent adverse events, such as peripheral neuropathy and fatigue. The nab-PTX naïve and reintroduction groups showed partial response in 2 and 0 patients, with a median progression-free survival of 7.6 and 1.4 months and median overall survival of 9.4 and 6.2 months, respectively. In the safety analysis, grade 3 peripheral neuropathy was observed in one patient in the nab-PTX reintroduction group, while other observed adverse events were grade 1 or 2.
Conclusion: This study suggests that GnP is safe and effective even after GEM-refractory PC, and GEM treatment followed by GnP may be a potentially effective treatment option for patients with nab-PTX-naïve PC.
Prognostic effect of the intensity of follow-up cystoscopy in patients with high-risk non-muscle invasive bladder cancer
Authors: Miyake Makito , Nishimura Nobutaka , Nishioka Yuichi , Fujii Tomomi , Oda Yuki , Miyamoto Tatsuki , Tomizawa Mitsuru , Shimizu Takuto , Owari Takuya , Ohnishi Kenta , Hori Shunta , Morizawa Yosuke , Gotoh Daisuke , Nakai Yasushi , Torimoto Kazumasa , Tanaka Nobumichi , Imamura Tomoaki , Fujimoto Kiyohide 
Published: August 2023

AbstractBackground There is a significant lack of evidence regarding the effect of non-adherence to recommended protocols in the follow-up of high-risk non-muscle-invasive bladder cancer (NMIBC) or the impact of delayed detection of recurrent lesions. Here, we investigated the optimal frequency of follow-up cystoscopy for high-risk NMIBC concerning oncological safety in a real-world Japanese clinical practice. Methods This retrospective, single-center study included 206 patients with high-risk primary NMIBC. The intensity (%) of follow-up cystoscopy was calculated based on actual cystoscopy visits and the recommended frequency in the first 24-month follow-up period. The inverse probability of treatment weighting analysis was used to reduce the risk of bias between the groups. We performed restricted cubic spline analysis with knots at the intensity of follow-up cystoscopy ≤ in the 100% group to examine the possible association between progression risk and the intensity of follow-up as a continuous exposure. Results The median intensity was 87.5% (interquartile range, 75%−100%). The adjusted multivariate analysis of MIBC-free and progression-free survival demonstrated no significant differences between the adjusted ≤75% and > 75% intensity groups. Restricted cubic spline analysis suggested no significant effect of follow-up intensity on progression risk, and the hazard ratios of patients with < 100% intensity were equivalent to those of patients with 100% intensity. Conclusion Our findings suggest that decreased intensity of follow-up cystoscopy does not affect oncological outcomes in patients with high-risk NMIBC. Further prospective trials directly aimed at investigating optimized follow-up schedules for NMIBC are mandatory before substantial changes to the existing clinical guidelines are made.
Push-pull cropping system soil legacy alter maize metabolism and fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae) resistance through tritrophic interactions”
Authors: Mutyambai Daniel Munyao , Mutua Johnstone Mutiso , Kessler André , Jalloh Abdul A. , Njru Basilio Ngari , Chidawanyika Frank , Dubois Thomas , Khan Zeyaur , Mohamed Samira , Niassy Saliou , Subramanian Sevgan 
Published: August 2023

Abstract
Background and aims
Crop cultivation practices and soil legacies are intrinsically linked and are hypothesized to influence plant direct and indirect defence against phytophagous insects. In this study, we tested how soils conditioned by push-pull (maize (Zea mays)- Desmodiumspp.- Brachiaria spp. intercrop) or maize monoculture (non-push-pull) affect maize (Zea mays) phytochemistry and subsequent resistance to fall armyworm (Spodoptera frugiperda Smith, Lepidoptera: Noctuidae).
Methods
Maize was grown in soils collected from push-pull and maize monoculture smallholder farmer fields. We compared maize growth, herbivore larval feeding, production of volatile and non-volatile defense secondary metabolites on maize grown in soils conditioned by push-pull and non-push-pull cropping. As a proxy for indirect defence effects, we also measured behavioural responses of egg-larval parasitoid Chelonus bifoveolatus Szpligeti (Hymenoptera: Braconidae) to maize volatiles from plants planted in soils conditioned by each cropping system.
Results
Maize plants grown in maize-Desmodium-Brachiariacompanion cropping conditioned soil had a better maize growth, higher and qualitatively different volatile and non-volatiles metabolites in plants in maize-Desmodium-Brachiaria companion cropping conditioned soil in comparison to plants grown in maize monoculture conditioned soil. Behavioural assays showed that S. frugiperda neonate fed more leaf tissue from maize plants planted in maize monoculture conditioned soil than those planted in maize-Desmodium-Brachiaria companion cropping conditioned soil. Parasitoid wasps were highly attracted to volatiles from maize planted in push-pull-conditioned soils than those planted in non-push-pull soils.
Conclusion
Our results indicate that conditioning soil with polyculture push-pull enhances maize growth, alters phytochemistry and subsequent direct and indirect resistance to S. frugiperda.
Neuroimaging characteristics of pruritus induced by eczema: An fMRI study
Authors: Wei Xiang-yu , Tao Larissa , Kim Tae-eun , Shen Wei-dong 
Published: August 2023

Abstract
Objective: To explore the neuroimaging characteristics of eczema-induced pruritus with resting-state functional Magnetic Resonance Imaging (rs-fMRI).
Methods: 42 patients with eczema were recruited in the PE group, and 42 healthy participants were included in the HC group. The Visual Analogue Score (VAS), 12-Item Pruritus Severity Scale (12-PSS), Pittsburgh Sleep Quality Index (PSQI) and Self-rating Anxiety Scale (SAS) were recorded in the PE group. The different values of fraction Amplitude of Low Frequency Fluctuation (fALFF) and functional connectivity(FC) were compared after rs-fMRI scanning.
Results: Compared with the HC group, the fALFF values of the left precentral gyrus, left postcentral gyrus, left supplementary motor area (SMA) and left midcingulate cortex in the PE group were increased. The FC values between the left precentral gyrus and bilateral superior temporal gyrus, bilateral hippocampus, left inferior occipital gyrus in the PE group were decreased. The FC values between left SMA and bilateral superior temporal gyrus in the PE group were decreased. The 12-PSS score was positively correlated with fALFF value of the left precentral gyrus and left postcentral gyrus.
Conclusion: Pruritus caused increased spontaneous activity in given cerebral regions, involving the perception of itch, control of scratching movements, and expression of itch-related emotions. Simultaneously, the aberrant fALFF values result in corresponding alterations in networks, primarily characterized by a bilateral decrease in the symmetry of FC values such as the superior temporal gyrus and the hippocampus. Meanwhile, there is a correlation between fALFF values of given cerebral regions and clinical scales, which provided potential neurobiological markers for the future study of pruritus.
Jets in Planetary Magnetosheath
Authors: Zhou Yufei , Raptis Savvas , Wang Shan , Shen Chao , Ren Nian , Ma Lan 
Published: August 2023

Abstract
The study of jets in the Earth's magnetosheath has been a subject of extensive investigation for over a decade due to their profound impact on the geomagnetic environment and their close connection with shock dynamics. While the variability of the solar wind and its interaction with Earth's magnetosphere provide valuable insights into jets across a range of parameters, a broader parameter space can be explored by examining the magnetosheath of other planets. Here we report the existence of anti-sunward and sunward jets in the Jovian and Kronian magnetosheath and show their close association to magnetic discontinuities. The anti-sunward jets are possibly generated by a shock—discontinuity interaction. Finally, through a comparative analysis of jets observed at Earth, Mars, Jupiter, and Saturn, we show that the size of jets scales with the size of bow shock.
Urinary lumirubin excretion in jaundiced preterm neonates during phototherapy with blue light-emitting diode vs. green fluorescent lamp
Authors: Uchida Yumiko , Takahashi Yukihiro , Kurata Chikara , Morimoto Yukihiro , Ohtani Eishin , Tosaki Asako , Kumagai Akiko , Greimel Peter , Nishikubo Toshiya , Miyawaki Atsushi 
Published: August 2023

Abstract
Phototherapy converts lipophilic unconjugated bilirubin to hydrophilic bilirubin photoisomers, such as lumirubin. We comparatively used a blue light-emitting diode (LED) and a green fluorescent lamp (FL) as light sources for phototherapy of hyperbilirubinemic preterm neonates with the aim of examining potential differences in urinary lumirubin excretion between these two wavelengths. Urinary lumirubin levels were measured using a fluorescence assay with blue light exposure in the presence of the unconjugated bilirubin-inducible fluorescent protein UnaG, and denoted as urinary UnaG-bound bilirubin (UUB)/creatinine (Cr) (µg/mg Cr). Preterm neonates born at ≤ 33 weeks gestational age and treated with phototherapy were subjected to this study. The maximum UUB/Cr level during phototherapy per device intensity was compared between neonates treated with the blue LED and the green FL. A total of 61 neonates were examined to determine the maximum UUB/Cr levels. The median of maximum UUB/Cr excretion per light intensity of each device (µg/mg Cr/µW/cm2/nm) was 0.21 for the blue LED and 0.32 for the green FL (p = 0.01). Green light was found to be more effective than blue one for bilirubin excretion via urinary lumirubin excretion. This is the first spectroscopic study to compare the efficacy of phototherapy at different wavelengths using fluorescence assay.
Quorum-Signaling Molecule Detection Based on Composite Sensors: Metal Oxides/Conducting Polymer
Authors: Gado Walaa , Al-Gamal Abdalrahman , Badawy Mona , Labena Ahmed , Zakaria Khaled , Kabel Khalid 
Published: August 2023

Abstract

N-hexanoyl-l-homoserine lactone (C6-HSL) is a distinctive signal produced by Gram-negative bacterial strains. The signal is used to cell-to-cell communication. Oil and gas companies are suffering from Microbiologically-influenced corrosion (MIC) induced Sulfate-reducing bacteria (SRB. SRB induce severe pitting corrosion on the metal surface especially when attached and form biofilms. Nowadays, scientists are looking for an applicable method to detect SRB-biofilms. Metal oxides (MOx) intercalated into a polymers matrix, specifically conducting polymers (CPs), to sense different biological molecules effectively such as C6-HSL due to its ability to form a coordination bond and its high selectivity. Therefore, this work was directed to provide a novel quorum-signaling molecule, C6-HSL, sensing technique to distinguish invisible SRB-biofilms attached to a metal surface. Hence, two different MOx/Polyaniline-Dodecyl benzene sulfonic acid (PANI-DBSA) composites (ZnO/PANI-DBSA and Fe2O3/PANI-DBSA) were synthesized and structurally characterized. Afterwards, the composites were applied with carbon paste 1% by weight over a carbon working electrode (WE) to detect the C6-HSL qualitatively and quantitatively via an electrochemical analysis. The electrochemical impedance spectroscopy (EIS) verified the ability of the obtained composites to monitor the C6-HSL produced by SRB-biofilm compared to the standard material. The monitoring composites achieved the intended results where the observation swapped from 50 to 1000 ppm of the C6-HSL concentrations. The limit of detection (LOD) of the ZnO/PANI-DBSA and Fe2O3/PANI-DBSA was 624 and 441 ppm, respectively. Furthermore, the SRB-biofilm was confirmed by a calorimetric measurement in addition to EIS, where the outcomes were compatible.
Photovoltaic and Battery sourced Multiport Converter fed Dual Active Bridge DC/DC converter with Multimode operation for Off-grid Electric Vehicle Charging Application
Authors: CHILAKALAPUDI GANESH , Das Saikat , Kumar Amritesh , N Phanindra A V V 
Published: August 2023

Abstract
In this paper, a multiport converter (MPC) fed bi-directional dual active bridge (DAB) DC-DC for charging an electric vehicle (EV) in an off-grid application is proposed. The MPC is with hybrid sources namely photo voltaic (PV) and battery. Further, these sources operate in different modes i.e., single input single output (SISO), single input dual output (SIDO), and dual input single output (DISO). In the SISO mode, two sub-operating modes are available. In the first sub-operating mode of SISO, the photovoltaic (PV) array alone supplies the load when the battery state of charge (SOC) is more than 95$\%$ during the daytime. In the second sub-operating of SISO, the battery is also able to serve the load during night-time when solar PV is not available. In the SIDO mode, the power output from the PV array is capable of meeting the load requirements and simultaneously supplying surplus energy to the battery for its charging purpose. In the DISO mode, the load is supported by both the solar PV and the battery concurrently. A centralized controller is developed to operate the MPC in all modes. The output of the MPC is fed to a bi-directional DAB DC-DC converter. In the present work, an optimized dual phase-shift (DPS) control scheme is aimed at reducing reactive power in the system and extending the ZVS range of operation. To validate the proposed MPC with different modes of operation and DAB DC-DC converter control scheme, a comprehensive simulation study is conducted using MATLAB/Simulink. The simulation setup involves a 3.8 kW system and considers different charging rates for an Electric Vehicle (EV).
Relationship between corneal astigmatism and the distribution of corneal thickness along different principal meridians
Authors: Zhu Liting , Yuan Zheng , Liang Shuangfeng , Zhao Dian , Zhou Chunyang 
Published: August 2023

Abstract
Aim: To analyze the relationship between corneal astigmatism (CA) and the distribution of corneal thickness along different principal meridians.
Methods: A total of 362 patients with 684 eyes who underwent preoperative examination for refractive surgery at Ineye Hospital of Chengdu University of TCM from April 2021 to August 2022 were included in the study. The automatic refractor was used to measure the degree and axis of CA. The Sim-K values and the mean corneal thickness of the principal meridian of maximum refractive power and the mean corneal thickness of the principal meridian of minimum refractive power were obtained using Sirius for the 3mm, 4.5mm, and 6mm range. The correlation between the difference in mean corneal thickness (dct) of the two principal meridians and CA measured by a computer refractometer was analyzed. Then, the participants were divided into three groups based on the degree of CA: low CA group: -1.00D~0.00D (210 eyes), moderate CA group: -2.00D~-1.25D (229 eyes), high CA group: ≤-2.25D (245 eyes). The range of dct values was analyzed for different degrees of CA.
Results: There was a negative correlation between dct and CA in the 3mm, 4.5mm, and 6mm ranges (r=-0.220, P<0.001; r=-0.214, P<0.001; r=-0.199, P<0.001). There was no difference in dct between the low and moderate astigmatism groups within a 3mm range (P>0.05). However, there were significant differences in dct between the low and high, moderate and high astigmatism groups within a 3mm range, as well as among the low, moderate, and high astigmatism groups within a 4.5mm and 6mm range (P<0.05).
Conclusion: The average corneal thickness of the principal meridian with maximum refractive power is thicker than that of the principal meridian with minimum refractive power. Additionally, as the degree of CA increases, the dct also increases. Corneal astigmatism is closely related to the distribution of corneal thickness in different principal meridians. In order to improve the accuracy of corneal astigmatism measurement, the factors of corneal thickness distribution in different principal meridians should be considered.
Associations between Adverse Childhood Experience Patterns and Anxiety and Depressive Symptoms among Chinese College Students
Authors: Li Xinxuan , Zhang Jian , Zhou Hong 
Published: August 2023

Abstract
Purpose With depression and anxiety becoming one of the major public health problems in China, more evidence shows the long-lasting negative effects of adverse childhood experiences (ACEs) on mental health. This study aimed to explore the ACE exposure patterns in Chinese college students and their associations with mental health problems in adulthood.Methods In this cross-sectional study, data were collected from the Chinese college students aged 18 years old and above. Depressive symptoms and anxiety were measured using the Depression Anxiety and Stress Scale (DASS-21). ACEs were measured with the International Adverse Childhood Experiences Questionnaire (ACE-IQ), and the ACE patterns were identified using latent class analysis (LCA). Then, logit regression models were employed to analyze the association between ACE exposure patterns and anxiety and depressive symptoms.Results A total of 536 Chinese college students were recruited in this study. Nearly 68.7% had at least one ACE and 17.2% were exposed to at least four types of ACEs. Three specific ACE patterns were identified, including “low ACEs” (63.1%), “family dysfunction but low childhood abuse” (20.1%), and “high domestic violence and childhood abuse” (16.8%). Compared with the “low ACEs” class, both the “high domestic violence and childhood abuse” class and the “family dysfunction but low childhood abuse” class showed significantly higher risks of depression and anxiety (P < 0.05).Conclusions The co-occurrence of ACEs was positively associated with higher risks of anxiety and depressive symptoms among Chinese college students and different patterns of ACE exposure may lead to diverse mental health outcomes.