bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relative efficiency of methods to estimate cabbage stem flea beetle (Psylliodes chrysocephala) larval infestation in oilseed rape (Brassica napus)
Authors: Seimandi‐Corda Gaëtan , Hall Jamie , Jenkins Todd , Cook Samantha M. 
Published: December 2022

AbstractBackgroundThe cabbage stem flea beetle (CSFB; Psylliodes chrysocephala) is an important pest of winter oilseed rape (OSR) crops in Europe. Damage is caused by adults feeding on young leaves and by larvae mining in the leaves and stems. The most common method to estimate the severity of CSFB larval infestation is by plant dissection, which is time consuming and labour intensive. Two alternative methods have been proposed: extraction of larvae from desiccating plants and counting the percentage of leaves with scars left by larvae on plant petioles. These methods are easy to implement and less time consuming than plant dissection but have not been properly validated.ResultsOSR plants were sampled in five different experiments and the two alternative methods tested; assessment of the total number of scars per plant as a predictor of the number of larvae was also tested. The number of larvae remaining in plants following various periods of desiccation was checked via plant dissection. We found that the desiccation method is efficient, giving reliable results after 7 days (76% of the total larvae extracted) with good accuracy in estimating the number of larvae per plant (±0.38 larvae per plant). The total number of scars also gives a reliable estimation of the number of larvae (r = 0.76, accuracy of ±1.01 larvae per plant).ConclusionOSR plant desiccation and the total number of scars per plant are reliable methods to estimate CSFB larval infestation and will facilitate monitoring of this cryptic pest stage. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Separation of perfluoroalkyl substances by ion chromatography with a resorcinarene stationary phase
Authors: Chan Wai Ning , Harrison Roger G. 
Published: December 2022

AbstractPerfluoroalkyl substances pose a worldwide environmental health risk. It is important to develop new detection and quantification methods for perfluoroalkyl substances. Currently, liquid chromatography‐tandem mass spectrometry is the proposed method to analyze perfluoroalkyl substances. Ion chromatography, with its ability to use water samples as they are collected, could be a promising technique to detect anionic perfluoroalkyl substances in water. A new cationic stationary phase, composed of a resorcinarene bound to arginine, was synthesized and used to separate perfluoroalkyl substances by ion chromatography. The new packing material under the right gradient conditions separates perfluoroalkyl substances such as perfluorobutanoic acid, perfluorobutanesulfonic acid, perfluoropentanoic acid, perfluorohexanoic acid, perfluorohexanesulfonic acid, and perfluorooctanoic acid. Unlike the case with common anions, it was found that decreasing the NaOH concentration in the eluent resulted in better perfluoroalkyl substances separation. The detection limits of the perfluoroalkyl substances were from 0.44 to 4.0 mg/L and the limits of quantification were from 1.5 to 13 mg/L. The retention times of the perfluoroalkyl substances were dependent on the number of CF2 groups and whether their acid group was sulfonate or carboxylate. Also, the detection of perfluoroalkyl substances in tap and lake water was accomplished.
The Suitability of Belgian Law to B Corp
Authors: Hiez David 
Published: December 2022

AbstractBelgian law is very interesting when considering B Corp, particularly since its major reform of company law. Originally duplicated from French law, Belgian company law remained B Corp friendly even after it started deviating from it at the end of the nineteenth century. Its first main amendment was the establishment of the social purpose company in 1995, one of the most stimulating legal dress for social enterprises. Its last originality, in 2020, is the regulation of both companies and associations in a same code, with many common provisions, and with a wide definition for both. This renews dramatically the opposition between the for-profit and the not-for-profit organisations.
Social Enterprises in the European Union: Gradual Recognition of Their Importance and Models of Legal Regulation
Authors: Vargas Vasserot Carlos 
Published: December 2022

AbstractThis chapter addresses social enterprises as a special corporate category, which in some European jurisdictions, and increasingly so after their promotion by the European Union, are provided with a specific legal framework to promote and encourage their development. The paper begins with a brief compilation of the several social enterprise concepts developed by economic doctrines both in the United States and Europe, which reveal a great diversity of approaches. This is followed by an analysis of the various documents published by the European Union, showing the increasing recognition of this business phenomenon, from the publication of the Social Business Initiative in 2011 to the recent Action Plan for the Social Economy in 2021. Finally, the results obtained from the analysis of the different European legal systems are presented, and three main models of legal regulation of social enterprises are distinguished, namely, the use of the social cooperative form, enactment of a special law, and integration into a social economy law. The chapter concludes with a table comparing the essential aspects of the regulation of social enterprises in 14 European countries.
Corporations with Social Aims in the Japanese Legal System
Authors: Matsumoto Nobuko 
Published: December 2022

AbstractIn Japan, there is no specific legislation for “benefit corporations” or “social enterprises,” and the concepts of those entities are not necessarily widely known. This does not mean that Japanese industry and society do not accept the idea of businesses with social aims. On the contrary, Japanese for-profit corporations have a tradition of conducting business with social aims, and there are various nonprofit corporation schemes that can be used when one incorporates businesses with social aims. In the author’s view, existing entities are succeeding in their efforts to engage in social business at least to a certain extent, and the necessity of the new structure has not been necessarily recognized. At the same time, existing entities are not perfectly suited for engaging in businesses with social aims. Speaking of share corporations, it is difficult for customers or investors to distinguish share corporations which surely pursue their social aims from others. Continued observation is needed on whether these businesses will grow by utilizing existing entities or new specific legal infrastructures will be introduced in the future.
Social Enterprises and Benefit Corporations in Spain
Authors: del Val Talen Paula 
Published: December 2022

AbstractThis chapter provides an overview of the legal framework for social enterprises in Spain and portrays the benefit-corporation phenomenon from the perspective of the Spanish law. The former is presided over by Ley 5/2011, de 29 de marzo, de Economía Social (LES), the main conceptual and policy aspects of which are discussed in this chapter. On the latter, since benefit corporations are not regulated in Spain, the contribution draws up their identifying elements from both a comparative methodology and a failed proposal for a general interest private limited liability company (S.L.I.G.). We consider benefit corporations and their applicable regime within the everlasting debate on the role of profit—both objective and subjective—as part of the cause of the company contract. Against this background, this chapter provides three theoretical models for benefit corporations under the Spanish company law and assesses how they may be adapted into the articles of association. We then examine how core finance and governance aspects may be touched, namely, the distribution of profits, directors’ duties, and shareholder protection mechanisms. The chapter supports the view that benefit corporations may be lawfully formed de lege lata under the Spanish companies and social enterprise law, although significant regulatory amendments are advisable to smoothen the process.
Ansätze for scattering amplitudes from p-adic numbers and algebraic geometry
Authors: De Laurentis Giuseppe , Page Ben 
Published: December 2022

Abstract
Rational coefficients of special functions in scattering amplitudes are known to simplify on singular surfaces, often diverging less strongly than the naïve expectation. To systematically study these surfaces and rational functions on them, we employ tools from algebraic geometry. We show how the divergences of a rational function constrain its numerator to belong to symbolic powers of ideals associated to the singular surfaces. To study the divergences of the coefficients, we make use of p-adic numbers, closely related to finite fields. These allow us to perform numerical evaluations close to the singular surfaces in a stable manner and thereby characterize the divergences of the coefficients. We then use this information to construct low-dimensional Ansätze for the rational coefficients. As a proof-of-concept application of our algorithm, we reconstruct the two-loop 0 → q$$ \overline{q} $$

q
¯

γγγ pentagon-function coefficients with fewer than 1000 numerical evaluations.
First evaluation of meson and τ lepton spectra and search for heavy neutral leptons at ILC beam dump
Authors: Nojiri Mihoko M. , Sakaki Yasuhito , Tobioka Kohsaku , Ueda Daiki 
Published: December 2022

Abstract
A beam dump experiment can be seamlessly added to the proposed Inter- national Linear Collider (ILC) program because the high energy electron beam should be dumped after the collision point. The ILC beam dump experiment will provide an excellent opportunity to search for new long-lived particles. Since many of them can be produced by a rare decay of standard model particles, we evaluate spectra of the mesons and τ lepton at the decay based on the PHITS and PYTHIA8 simulations. As a motivated physics case, we study the projected sensitivity of heavy neutral leptons at the ILC beam dump experiment. The heavy neutral leptons can also be produced via deep inelastic scattering and Z boson decay at the ILC main detector, which we include in the projection. With the multi-track signal, the reach would be greatly extended in mass and coupling, even compared with the other proposed searches.
Charting the Higgs self-coupling boundaries
Authors: Durieux Gauthier , McCullough Matthew , Salvioni Ennio 
Published: December 2022

Abstract
Could new physics first manifest itself in Higgs self-coupling measurements? In other words, how large could deviations in the Higgs self-coupling be, if other Higgs and electroweak measurements are compatible with Standard Model predictions? Using theoretical arguments supported by concrete models, we derive a bound on the ratio of self-coupling to single-Higgs coupling deviations in ultraviolet completions of the Standard Model where parameters are not fine-tuned. Broadly speaking, a one-loop hierarchy is allowed. We thus stress that self-coupling measurements at the LHC and future colliders probe uncharted parameter space, presenting discovery potential even in the absence of emerging hints in single-Higgs coupling measurements. For instance, if other observables show less than two-sigma deviations by the end of the LHC programme, the Higgs self-coupling deviations could still exceed 200% in the models discussed, without introducing fine-tuning of ultraviolet parameters.
Robustness of texture-based roundwood tracking
Authors: Wimmer Georg , Schraml Rudolf , Hofbauer Heinz , Petutschnigg Alexander , Uhl Andreas 
Published: December 2022

AbstractThe proof of origin of wood logs is becoming more and more important. In the context of Industry 4.0 and to combat illegal logging, there is an increased interest to track each individual log. There were already previous publications on wood log tracing using image data from logs, but these publications used experimental setups that cannot simulate a practical application where logs are tracked between different stages of the wood processing chain, like e.g. from the forest to the sawmill. In this work, we employ image data from the same 100 logs that were acquired at different stages of the wood processing chain (two datasets at the forest, one at a laboratory and two at the sawmill including one acquired with a CT scanner). Cross-dataset wood tracking experiments are applied using (a) the two forest datasets, (b) one forest and the RGB sawmill dataset and (c) different RGB datasets and the CT sawmill dataset. In our experiments we employ two CNN based method, 2 shape descriptors and two methods from the biometric areas of iris and fingerprint recognition. We will show that wood log tracing between different stages of the wood processing chain is feasible, even if the images at different stages are obtained at different image domains (RGB-CT). But it only works if the log cross sections from different stages of the wood processing chain either offer a good visibility of the annual ring pattern or share the same woodcut pattern.
Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder
Authors: Tan Haoye , Hubertus Simon , Thomas Sebastian , Lee Alycia M. , Gerhardt Sarah , Gerchen Martin Fungisai , Sommer Wolfgang H. , Kiefer Falk , Schad Lothar , Vollstädt-Klein Sabine 
Published: December 2022

Abstract
Rationale
Brain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration.

Objectives
In this study, we used quantitative susceptibility mapping (QSM), an emerging MRI technique developed for quantifying tissue magnetic susceptibility, to examine brain iron accumulation in individuals with alcohol use disorder (AUD) and its relation to compulsive drinking.

Methods
Based on our previous projects, QSM was performed as a secondary analysis with gradient echo sequence images, in 186 individuals with AUD and 274 healthy participants. Whole-brain susceptibility values were calculated with morphology-enabled dipole inversion and referenced to the cerebrospinal fluid. Then, the susceptibility maps were compared between AUD individuals and healthy participants. The relationship between drinking patterns and susceptibility was explored.

Results
Whole-brain analyses showed that the susceptibility in the dorsal striatum (putamen and caudate) among AUD individuals was higher than healthy participants and was positively related to the Obsessive Compulsive Drinking Scale (OCDS) scores and the amount of drinking in the past three months.

Conclusions
Increased susceptibility suggests higher iron accumulation in the dorsal striatum in AUD. This surrogate for the brain iron level was linearly associated with the compulsive drinking pattern and the recent amount of drinking, which provides us a new clinical perspective in relation to brain iron accumulation, and also might indicate an association of AUD with neuroinflammation as a consequence of brain iron accumulation. The iron accumulation in the striatum is further relevant for functional imaging studies in AUD by potentially producing signal dropout and artefacts in fMRI images.
Skin laceration caused by a short distance shot from a pepper spray launcher: a case report
Authors: Weber Anja , Wöss Claudia , Kneubuehl Beat P. , Rabl Walter 
Published: December 2022

Abstract
Pepper spray launchers are more precise and wind stable compared to conventional pepper sprays and are commonly used as a self-defensive tool. With the advanced potential, they may also harbour a greater risk for injuries, especially if they are not used within the suggested safety distance. If the shooting distance is below 1.5 m, energy densities may exceed the threshold energy density for the penetration of skin leading to skin laceration. We present a case where a man is hit by the liquid jet of a JPX Jet Protector® with an estimated shooting distance of 0.3 m. The man suffered from a bleeding skin laceration, which had to be sewed in the hospital. This case report furthermore outlines the potentially dangerous effect of pepper spray launchers and thereby their role in forensic investigations.
Retinal microvascular density analysis in patients with rheumatoid arthritis treated with hydroxychloroquine
Authors: Esser Eliane Luisa , Zimmermann Julian Alexander , Storp Jens Julian , Eter Nicole , Mihailovic Nataša 
Published: December 2022

Abstract
Purpose
Rheumatoid arthritis (RA) is the most common inflammatory joint disease, and hydroxychloroquine (HCQ) is an established treatment. The extent to which HCQ impacts ocular microvascular vessel density (VD) in patients with RA without evidence of HCQ retinopathy has not yet been conclusively clarified. The main aim of this study was to evaluate VD measured by optical coherence tomography angiography (OCTA) in patients with RA treated with HCQ.

Methods
The VD data of the 3 × 3 mm OCT angiogram (RTVue XR Avanti, Optovue Inc., Fremont, California, USA) as well as the retinal thickness (RT) data of patients with RA (n = 30) and healthy controls (n = 30) were extracted and analyzed. The study group was further divided into patients undergoing HCQ treatment for > 5 years (high-risk-group) and < 5 years (low-risk group).

Results
Patients with RA showed no evidence of VD reduction compared to the control group in all obtained regions (p > 0.05). Correlation analysis revealed no dependency between VD, RT, and HCQ therapy duration or cumulative HCQ dose (p > 0.05). High-risk patients showed a decreased VD in the superficial quadrant of the superficial capillary plexus compared to low-risk-patients (p = 0.022). Whole-en-face RT was reduced in the high-risk group compared to the control group (p = 0.019).

Conclusion
Our study showed no evidence that HCQ diminishes VD in patients with RA without HCQ retinopathy measured by OCTA. However, RA patients with a long duration of therapy showed a significantly reduced RT. Our results suggest that quantitative VD analysis by OCTA may not be suitable for early detection of HCQ retinopathy and that the focus on detecting early HCQ retinopathy should be on intensive and sequential OCT diagnostics.
International Consensus Classification of myeloid and lymphoid neoplasms: myeloproliferative neoplasms
Authors: Gianelli Umberto , Thiele Jürgen , Orazi Attilio , Gangat Naseema , Vannucchi Alessandro M. , Tefferi Ayalew , Kvasnicka Hans Michael 
Published: December 2022

AbstractThe recently published International Consensus Classification (ICC) of myeloid neoplasms summarized the results of an in-depth effort by pathologists, oncologists, and geneticists aimed to update the 2017 World Health Organization classification system for hematopoietic tumors. Along these lines, several important modifications were implemented in the classification of myeloproliferative neoplasms (MPNs). For chronic myeloid leukemia, BCR::ABL1-positive, the definition of accelerated and blast phase was simplified, and in the BCR::ABL1-negative MPNs, the classification was slightly updated to improve diagnostic specificity with a more detailed and better validated morphologic approach and the recommendation of more sensitive molecular techniques to capture in particular early stage diseases. In this regard, high sensitive single target (RT-qPCR, ddPCR) or multi-target next-generation sequencing assays with a minimal sensitivity of VAF 1% are now important for a proper diagnostic identification of MPN cases with low allelic frequencies at initial presentation. This review discusses the updated diagnostic criteria of MPN according to the ICC, particularly by highlighting the new concepts and how they can be applied in clinical settings to obtain an appropriate prognostic relevant diagnosis.
Reproduktives Timing. Neue Formen und Ambivalenzen zeitlicher Optimierung von Fortpflanzung und ihre ethischen Herausforderungen
Authors: King Vera , Lodtka Pia , Marcinski-Michel Isabella , Schreiber Julia , Wiesemann Claudia 
Published: December 2022

ZusammenfassungDer Beitrag befasst sich mit dem Zusammenhang von Fortpflanzung, Zeit und gutem Leben. Angebote der Reproduktionsmedizin und Konzeptionen des guten Lebens in der Zeit beeinflussen einander wechselseitig, wobei diese Wechselwirkung durch implizite oder explizite normative Setzungen und Erwartungen von angemessener Zeitlichkeit gekennzeichnet ist. Wir erörtern zunächst die Bedeutung von Zeit für Lebenslauf und Elternschaft aus einer soziologisch-sozialpsychologischen Perspektive. Fortpflanzungsmedizin kann die Spielräume für Elternwerden und für lebenszeitliche Autonomie vergrößern, aber im Kontext gesellschaftlicher Optimierungs- und Effizienzimperative auch gegenteilige Auswirkungen haben und Heteronomie verstärken. Insgesamt ergeben sich daraus veränderte Formen von Anpassung und Selbstbestimmung, neue Dilemmata und Ambivalenzen der zeitlichen Optimierung von Elternschaft. Vor diesem Hintergrund erläutern wir, wie die Ethik der Fortpflanzungsmedizin von einer interdisziplinären, das Leben in seinem zeitlichen Verlauf in den Blick nehmenden Forschung profitieren könnte.
Studies of the symmetric binding mode of daclatasvir and analogs using a new homology model of HCV NS5A GT-4a
Authors: Saad Kholoud A. , Eldawy Mohammed A. , Elokely Khaled M. 
Published: December 2022

Abstract
Context
Egypt has a high prevalence of the hepatitis C virus (HCV) genotype 4a (GT-4a). Unfortunately, the high resistance it exhibited still was not given the deserved attention in the scientific community. There is currently no consensus on the NS5A binding site because the crystal structure of HCV NS5A has not been resolved. The prediction of the binding modes of direct-acting antivirals (DAA) with the NS5A is a point of controversy due to the fact that several research groups presented different interaction models to elucidate the NS5A binding site. Consequently, a 3D model of HCV NS5A GT-4a was constructed and evaluated using molecular dynamics (MD) simulations. The generated model implies an intriguing new orientation of the AH relative to domain I. Additionally, the probable binding modes of marketed NS5A inhibitors were explored. MD simulations validated the stability of the predicted protein–ligand complexes. The suggested model predicts that daclatasvir and similar drugs bind symmetrically to HCV NS5A GT-4a. This will allow for the development of new NS5A-directed drugs, which may result in reduced resistance and/or a wider range of effectiveness against HCV.

Methods
The 3D model of HCV NS5A GT-4a was constructed using the comparative modeling approach of the web-based application Robetta. Its stability was tested with 200-ns MD simulations using the Desmond package of Schrodinger. The OPLS2005 force field was assigned for minimization, and the RMSD, RMSF, and rGyr were tracked throughout the MD simulations. Fpocket was used to identify druggable protein pockets (cavities) over the simulation trajectories. The binding modes of marketed NS5A inhibitors were then generated and refined with the aid of docking predictions made by FRED and AutoDock Vina. The stability of these drugs in complex with GT-4a was investigated by using energetic and structural analyses over MD simulations. The Prime MM-GBSA (molecular mechanics/generalized Born surface area) method was used as a validation tool after the docking stage and for the averaged clusters after the MD simulation stage. We utilized PyMOL and VMD to visualize the data.