bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies for managing major diseases in Asian seabass aquaculture
Authors: Yue Genhua , Guo Changjun 
Published: February 2025

Abstract
Asian seabass (Lates calcarifer) is becoming an important species for aquaculture. However, the Asian seabass aquaculture industry faces a significant challenge of disease outbreaks that can jeopardize fish health and production. This review delves into the major diseases affecting Asian seabass aquaculture and explores their causes, symptoms, and management approaches. We focused on the key pathogens responsible for these outbreaks, the environmental factors contributing to disease susceptibility, and the latest advancements in disease prevention and management. By addressing these critical aspects, this review addresses the needs of aquaculturists, researchers, and policymakers with the knowledge required to promote resilient and sustainable Asian seabass farming. We aim to shed light on the challenges posed by disease while highlighting innovative strategies that offer promise for the future of this thriving industry. This comprehensive examination serves as a valuable resource for those invested in ensuring the health and vitality of Asian seabass, securing a consistent supply to meet the demands of global seafood markets.
Developing and Validating an Automatic Support System for Tumor Coding in Pathology Reports in Spanish
Authors: Villena Fabián , Báez Pablo , Peñafiel Sergio , Rojas Matías , Paredes Inti , Dunstan Jocelyn 
Published: February 2025

PURPOSE
Pathology reports provide valuable information for cancer registries to understand, plan, and implement strategies to mitigate the impact of cancer. However, coding essential information from unstructured reports is performed by experts in a time-consuming manual process. We developed and validated a novel two-step automatic coding system that first recognizes tumor morphology and topography mentions from free text and then suggests codes from the International Classification of Diseases for Oncology (ICD-O) in Spanish.

MATERIALS AND METHODS
We created an annotated corpus of tumor morphology and topography mentions consisting of 1,101 documents. We combined it with the CANTEMIST corpus (Cancer Text Mining Shared Task). Specifically, we implemented a named entity recognition (NER) model using the bidirectional long short-term memory network-conditional random field architecture enhanced with a stacked embedding layer. We applied transfer learning from state-of-the-art pretrained language models to obtain high-quality contextual representations, thus improving the detection of entities. The mentions found using this model were subsequently coded using a search engine tailored to the ICD-O codes.

RESULTS
Our NER models achieved an F1 score of 0.86 and 0.90 for tumor morphology and topography, respectively. The overall performance of our automatic coding system achieved an accuracy at five suggestions of 0.72 and 0.65 for tumor morphology and topography, respectively.

CONCLUSION
These results demonstrate the feasibility of implementing natural language processing tools in the routine of a cancer center to extract and code valuable information from pathology reports. Our recommender system allows reliable and transparent coding at the moment of consultation. This publication shares the annotated corpus in Spanish, annotation guidelines, and source code to reproduce our experiments.
Effect of different protease on the hydrolysis degree and antigenicity of cow milk protein
Authors: Chu Xiaojun , Li Ling , Fang Ruosi , Li Guipu , Xiong Lina , Liu Donghong 
Published: February 2025

Abstract
Cow milk protein (CMP) has high nutritional value and is a common food additive, but its allergenicity has raised concerns. In this study, we investigated whey protein and casein hydrolysis as a potential method of lowering CMP antigenicity. We tested three endo-type proteases (neutral protease, papain, trypsin) and one exo-type protease (flavourzyme). We applied response surface methodology to obtain optimized conditions for each enzyme, decreasing antigenicity by >75 %. Maximum hydrolysis of whey protein and casein was achieved with a combination of proteases (1:1.5 papain to flavourzyme, 1:2 and 1:1.5 neutral to flavourzyme in whey protein and casein, respectively). Antigenicity rates declined by 85–92 % across all treatments. The proportion of small-molecular-weight components in enzymatic hydrolysate rose 87–90 %, indicating low antigenicity. Experiments using protein hydrolysates and in vitro simulated digestion tracts revealed decreasing antigenicity as digestion proceeded. Our findings have important implications for the development of hypoallergenic milk products.
The Challenging Terrain of Critical Infrastructures – A Geopolitical Perspective
Authors: Gehringer Agnieszka 
Published: February 2025

Abstract
With intensifying weaponized conflicts and authoritarian tendencies across countries, geopolitical risks related to critical infrastructure (CI) have increased. However, views on what exactly constitutes CI, what risks are associated with it, especially when control of it is ceded to foreign operators, and what strategies are best suited to manage these risks and make CI more resilient, vary widely among experts in the field and among governments and institutions concerned with CI protection and resilience. This paper compares the existing concepts and approaches adopted in the scientific work and across major developed economies to identify and manage risks related to CI, focusing on geopolitical aspects of CI protection and resilience. It eventually postulates that a comprehensive and coherent framework is needed to address the underlying (geopolitical) risks and thus achieve more resilient CI systems. Especially in the European Union, a more active and systematic dialog is required to enhance the common understanding of critical infrastructures, their sectoral and transboundary interdependences and the role of resilience therein. Failing to do so in a context of intensifying geopolitical tensions could turn the new mantra of “de-risking” strategies into an empty phase.
Hohensalzburg Digital: Engaging the Public via a Local Time Machine Project
Authors: Antenhofer Christina , Matschinegg Ingrid , Brandstätter Walter , Zedlacher Stefan 
Published: February 2025

Abstract
Hohensalzburg Digital is a Digital Humanities project realized at Salzburg University and dedicated to digitally process and connect room- and object-related information taken from written sources and from building history data on Hohensalzburg Castle. Via digital interfaces, we create the basis for an Austrian Local Time Machine Project on the castle, a popular landmark. In three steps, the project opens up cultural heritage digitally for scientific community and international public alike: (1) The first part is dedicated to digital processing and exploring historical sources on rooms of the castle, their furnishings and function, from the earliest sources dating back to the sixteenth century until 1816 when Salzburg became part of the Habsburg Empire. (2) The second part connects the historical information deduced from the written sources with the results of building research and other work on realia, for example, on the famous tiled stove in the Goldene Stube (Golden Chamber). The digital room book created in this way allows a new comprehensive view on the development, furnishings, and use of the rooms and the whole building as a social space for the people who lived there. (3) The final part prepares the data for incorporation in the Europe Time Machine.
Evaluating the Impact of Optimizer Hyperparameters on ResNet in Hanacaraka Character Recognition
Authors: Sudewo Egidio Bagus , Kunta Biddinika Muhammad , Umar Rusydi , Fadlil Abdul 
Published: February 2025

Abstract
This study evaluates the performance of various optimizers on a ResNet-18 based Convolutional Neural Network (CNN) model for the task of recognizing Hanacaraka Javanese script characters. The image dataset is divided into three sets: training, validation, and test, with image sizes of 64 × 64 pixels and a batch size of 64. The tested optimizers include SGD, Adam, RMSprop, Adagrad, Adadelta, NAdam, and Adamax, all with a learning rate of 0.001 and trained for 10 epochs. The results show that NAdam provides the best performance with accuracy, precision, recall, and F1-Score values reaching 100 %, followed by Adamax with metrics above 97 %. Adam and Adagrad also demonstrate high performance with metric values above 97 %. Meanwhile, SGD shows fairly good performance with an accuracy of 93.72 %, and Adadelta shows adequate performance with an accuracy of 86.58 %. RMSprop yields the lowest performance with an accuracy of 81.74 %. Accuracy and loss graphs indicate that Adam and Adadelta offer the best balance between training and validation performance, while RMSprop and NAdam exhibit significant instability. This study highlights the importance of selecting the appropriate optimizer to achieve optimal performance in Hanacaraka character classification, with NAdam and Adamax being the best choices.
Patient-specific 3D-tissue slices from peritoneal metastases – An in vitro model for individual susceptibility analysis
Authors: Etzold Christian , Lyros Orestis , Mehdorn Matthias , Nowotny Robert , Niebisch Stefan , Jansen-Winkeln Boris , Schierle Katrin , Gockel Ines , Thieme René 
Published: February 2025

Abstract

Objectives
The prognosis of patients with peritoneal metastases (PM) is poor, and these patients have a brief overall survival. Most patients with advanced PM receive palliative therapy to maintain their quality of life. In our current study, we investigated whether patient-specific 3D-tissue slices from patients with PM subjected to pressurized intraperitoneal aerosol chemotherapy could be cultured in vitro.

Methods
Biopsies from gastric cancer patients with PM were characterized for cytokeratin-positive tumor cells and the proliferation marker Ki-67. Biopsies from seven patients were cut to 350 µM thick slices in a standardized manner, cultured with 10 µM 5-fluorouracil, doxorubicin, cisplatin, oxaliplatin, or irinotecan for 96 h, and then examined histopathologically and via immunohistochemistry for persistent cytokeratin and Ki-67 expression.

Results

In vitro cultured slices revealed a similar morphology to un-cultured specimens, and Ki-67-positive tumor cell areas were present after 96 h. The total amount of tumor cells per slice was determined by pan-cytokeratin staining. In the doxorubicin-treated slices, the cytokeratin-positive tumor cell fraction and proliferative (Ki-67pos) cells were decreased. Patient-specific 3D-tissue-slice cultures from peritoneal biopsies were cultured in vitro for up to 4 days.

Conclusions
Potentially, these cultures are a reliable model to evaluate the chemosensitivity of patients with PM. Further investigation is needed to match the chemosensitivity with the clinical course of these patients.
Experimental Study on the Salt Migration Behavior of Coarse-Grained Saline Soils Subgrade under Strong Evaporation Environment
Authors: Wang Ying , Yang Xi , Zhang Yong Zhi , Liu Ji Lin 
Published: February 2025

Abstract
This paper studied saline soil’s water and salt migration behavior under evaporation conditions by a self-designed experimental device, and the evolution law of the water content, conductivity, and temperature in different heights of saline soil roadbeds was analyzed. The test results show that at an ambient temperature of 18°C, the water-salt migration of saline roadbed is mainly concentrated in the early stage of hydration (≤48 h), which shows a typical phenomenon in which salt in the soil follows the water and the conductivity of soils increases synchronously with the water content. Under the evaporation condition, the decreased rate of water content was accelerated in the sample area near the heat source, resulting in a constant increase in the rate of conductivity and a wider salt aggregation area. Further, a critical subgrade height prediction model is established based on the maximum salt and water migration height in saline soil roadbeds with the help of Hydrus numerical simulation software. The model analysis results show that the migration rate of salts gradually lags behind that of water because the burial depth of groundwater increases under evaporation conditions. When the burial depth of groundwater is &lt;1.5 m, the change of water-salt migration of the roadbed is gradually stabilized, and the height of salt erosion area on saline soil roadbed no longer rises. The research conclusions can guide the design level of the structure of saline soil roadbeds under evaporation conditions.
The antibacterial and antibiofilm properties of bee products against certain bacteria
Authors: Ozdikmenli Tepeli S. 
Published: February 2025

AbstractAntibiotics are employed worldwide for both prevention and therapeutic purposes against infectious diseases on dairy farms. Recurrent infections frequently arise from biofilm-forming bacteria. This research aimed to evaluate the efficacy of oak honey, honeycomb capping, and propolis against certain biofilm-associated and antibiotic-resistant bacteria. The total phenolic content (TPC) values for propolis, honeycomb capping, and oak honey samples were 298, 128, and 72 mg of gallic acid equivalent (GAE)/100 g, respectively. Oak honey showed the lowest minimum inhibitory concentration (MIC) value (<0.08%) against the strong biofilm of non-blaCTX-M Serratia fonticola-1. Propolis had the lowest MIC value (<0.03%) against the weak biofilm of blaCTX-M positive Citrobacter braakii, and the moderate biofilm of non-blaCTX-M S. fonticola-2. The MIC values of all bee products showed a significant decrease upon interaction with 1% boric acid for all strains. Moreover, propolis has shown the ability to reduce 96% of the biofilm biomass of Citrobacter braaki after 24 h. The results show that bee products, used for medicinal purposes since ancient times, have emerged as a viable alternative against environmental pathogens.
Dynamic mechanical analysis (DMA) of photopolymers: A new protocol for 3D-printed materials
Authors: Schittecatte Laura , Bonamy Daniel , Guenoun Patrick , Liénard Antoine , Nguyen Thuy , Geertsen Valérie 
Published: February 2025

Abstract
This work provides a complete methodology to measure the storage modulus of vat 3D-printed polymers via Dynamic Mechanical Analysis (DMA) which could enable real intercomparison of printing materials mechanical performance. We propose an 8-step methodology that includes the determination of the linear viscoelastic region (LVER) and the glass transition temperature (Tα), as well as a stress relief annealing post-treatment that is proven to significantly reduce the dispersion of 3D-printed samples. The methodology applied to various 3D-printed resin samples, achieving repeatability and reproducibility values comparable to those of a reference molded PMMA.

Graphical abstract
A synchrotron X-ray diffraction and electron microscopy study of vanadium-doped UO2
Authors: Murphy Gabriel L. , Marquardt Julien , Klinkenberg Martina , Shirokiy Daniil , Kegler Philip , Henkes Maximilian , Bukaemskiy Andrey , Richter Selina , Braga Luiza , Hennig Christoph , Bosbach Dirk 
Published: February 2025

Abstract
The doping of UO2 ceramics with transition metal elements such as vanadium is a topical enterprise due to the relevance to advanced technology nuclear fuels in addition to understanding fuel-cladding interactions in spent nuclear fuel. Herein, the lattice and microstructural dependence of V-doped UO2 ceramics synthesized under conditions of − 420 kJ/mol and 1700 °C with elemental additions of 0, 500, 1000 and 2000 ppm was established using high-resolution synchrotron X-ray powder diffraction and scanning electron microscopy. Microstructural analysis indicates moderate growth of the UO2 grain structure is achieved with V doping, but not as appreciable as gold-standard Cr-doped UO2. Collected diffractograms, analysed using the Rietveld method, indicate similar levels of solubility of V in comparison to Cr-doped UO2 under like conditions. The results of this investigation were discussed in relation to current structural models of lattice incorporation of transition metals in UO2.

Graphical abstract
Occupational therapy in the bereavement process: A meta-synthesis
Authors: Dahdah Daniel Ferreira , Joaquim Regina Helena Vitale Torkomian 
Published: February 2025

Introduction: Bereavement is a complex process characterised by a state of grief and suffering, which impacts the health and well-being of the bereaved, and extends to their occupational performance. Thus, occupation can be understood to be central in the expression of bereavement after the death of a loved one as it mediates identity formation, interpersonal relationships, a sense of belonging, and future perspectives. Purpose: To review English and Portuguese literature and identify how occupational therapists perceive and/or intervene in the bereavement process.
Method: A meta-synthesis was conducted by database search and article analysis. Results and Discussion: Eight qualitative style articles were analysed. From these, three categories were derived from the content analysis: 1) Relationship between study participants and the deceased; 2) Occupational repercussions of bereavement; and 3) Occupation as a means to an end in the therapy process of the bereaved.
Conclusions: Although the need for studies of the bereavement process and its implications for occupations is urgent, this study points out that occupations can be predictors of understanding the elaboration process through occupational engagement and that they also act as a potential resource to construct meaning about the death of the loved one.
Keywords: Occupational therapy, bereavement, grief, mourning, attitude to death
Visual perception of five-year-old Afrikaans-speaking children in Bloemfontein using the VMI-6, DTVP-3 and TVPS-3: a follow up study
Authors: Visser Marieta , Nel Mariette 
Published: February 2025

DOI: http://dx.doi.org/10.17159/2310-3833/2017/vol48n3a6South African Journal of Occupational Therapy. 2018; 48 (2):31-43Background and aim: Previous research investigated the latest versions of the Beery-Buktenica Developmental Test of Visual-motor Integration 6th edition (Beery VMI-6), Development Test of Visual Perception 3rd edition (DTVP-3) and Test of Visual Perceptual Skills 3rd edition (TVPS-3) on five-year-old English-speaking children. This study aimed to extend the investigation, to five-year-old Afrikaans-speaking children, and to compare the results to previous findings on English-speaking children of a similar age.Methods: A quantitative, cross-sectional investigation into the visual perception and visual-motor performance of five-year-old Afrikaans-speaking children (n=52) was conducted at Afrikaans Language of Learning and Teaching (ALOLT) schools in Bloemfontein, by using these tests according to the prescribed procedures, in a specific order and with adequate breaks between tests.Results: Both language groups' performance on the Beery VMI-6 and DTVP-3 compared well to the American normative sample, but below average on all the TVPS-3 composite scores. The Beery VMI-6 motor coordination sub-test yielded statistically significant gender differences. No significant language differences were noted in the three tests. A statistically significant difference was identified between form constancy and visual closure sub-tests of the DTVP-3 and the TVPS-3, and when the Beery VMI-6 visual-motor integration sub-test was compared to the DTVP-3copying sub-test.Conclusions: Occupational therapists are encouraged to consider the suitability of the three tests, and further research in this field is recommended.Â Key words: visual perceptual tests; visual-motor performance; five-year-old children; Beery VMI-6; DTVP-3; TVPS-3
Análise do saneamento básico e as doenças relacionadas em Mato Grosso do Sul
Authors: Bilck Kharlla Franco dos Santos , Morato Priscila Neder 
Published: February 2025

O saneamento básico é o conjunto de serviços públicos, infraestruturas e instalações operacionais relacionados ao abastecimento de água; esgotamento sanitário; limpeza urbana e manejo de resíduos sólidos; e drenagem e manejo das águas pluviais urbanas. O objetivo desta pesquisa é compreender a situação em que se encontra o sistema de saneamento básico e o impacto sobre as doenças relacionadas em Mato Grosso do Sul, identificando a dimensão do acesso que os sul-mato-grossenses possuem quanto a esses serviços e/ou a falta e precariedade desses e a relação com a ocorrência de doenças na população. Com os resultados encontrados, observa-se que os investimentos em saneamento tiveram um desenvolvimento, mas ainda falta muito para a universalização no estado, tendo em vista que é extremamente importante o acesso a condições sanitárias básicas a toda população e que a falta e/ou precariedade pode acarretar doenças.
Long term analysis of the link between practices and vineyard decline in relation to abiotic factors
Authors: Merot Anne , Thiollet-Scholtus Marie , Sladeczek Marc , Hossard Laure , Smits Nathalie 
Published: February 2025

Vineyard decline is one of the main challenges viticulture now faces, especially in the current context of climate change. While decline is often attributed to grapevine trunk diseases and climate change, it also involves a myriad of other interconnected factors, including agricultural practices, whose role in decline remains unclear. This study explored for the first time how various planting conditions and agricultural practices implemented over an extended period of time affect the intensity and dynamics of decline. We analysed a large dataset obtained from 107 plots in the Cognac wine-growing region in western France from 1988 to 2018. The dataset included data on soil and climate conditions, genetic material at planting, annual agricultural practices, and information on annual mortality and yield. This study comprised six steps: dataset building, characterisation of decline categories, selection of explanatory variables to be studied, creation of plot trajectories based on agricultural practices, linking of decline categories and plot trajectories, and analysis of plot characteristics and practices. Using data from 43 plots and 58 variables, we showed that vineyard plots can be classified into three stages of decline depending on the dynamics and intensity of mortality and yield dynamics. We then established 11 trajectories over the plot lifespans (16 to 30 years). A detailed analysis of these trajectories revealed that plots associated with certain trajectories were more subject to decline, which helped us identify strategies that could limit or even prevent decline. We concluded that preventing decline requires adopting an integrated approach from planting to grubbing up, finding the right match between genetic material and soil–climate conditions, ensuring optimal water management, and managing potentially competing vegetation, like cover cropping. By identifying key practices over the vineyard lifespan, this study opens up new avenues for preventing decline by putting the focus on vigour management, water and mineral status of the plant.