bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interaction of mental comorbidity and physical multimorbidity predicts length-of-stay in medical inpatients
Authors: Stahl-Toyota Sophia , Nikendei Christoph , Nagy Ede , Bönsel Stefan , Rollmann Ivo , Unger Inga , Szendrödi Julia , Frey Norbert , Michl Patrick , Müller-Tidow Carsten , Jäger Dirk , Friederich Hans-Christoph , Hochlehnert Achim 
Published: June 2023

Background
Mental comorbidities of physically ill patients lead to higher morbidity, mortality, health-care utilization and costs.

Objective
The aim of the study was to investigate the impact of mental comorbidity and physical multimorbidity on the length-of-stay in medical inpatients at a maximum-care university hospital.

Design
The study follows a retrospective, quantitative cross-sectional analysis approach to investigate mental comorbidity and physical multimorbidity in internal medicine patients.

Patients
The study comprised a total of n = 28.553 inpatients treated in 2017, 2018 and 2019 at a German Medical University Hospital.

Main measures
Inpatients with a mental comorbidity showed a median length-of-stay of eight days that was two days longer compared to inpatients without a mental comorbidity. Neurotic and somatoform disorders (ICD-10 F4), behavioral syndromes (F5) and organic disorders (F0) were leading with respect to length-of-stay, followed by affective disorders (F3), schizophrenia and delusional disorders (F2), and substance use (F1), all above the sample mean length-of-stay. The impact of mental comorbidity on length-of-stay was greatest for middle-aged patients. Mental comorbidity and Elixhauser score as a measure for physical multimorbidity showed a significant interaction effect indicating that the impact of mental comorbidity on length-of-stay was greater in patients with higher Elixhauser scores.

Conclusions
The findings provide new insights in medical inpatients how mental comorbidity and physical multimorbidity interact with respect to length-of-stay. Mental comorbidity had a large effect on length-of-stay, especially in patients with high levels of physical multimorbidity. Thus, there is an urgent need for new service models to especially care for multimorbid inpatients with mental comorbidity.
Perlindungan Hukum Penyewa Gedung Hotel Atas Penundaan Pelaksanaan Perjanjian Sewa Gedung Hotel Pada Masa Pandemi Covid-19
Authors: Njatrijani Rinitami , Madjan Aldhika Benjamin 
Published: June 2023

The Covid-19 pandemic caused the government to prohibit community activities outside the home which might cause crowds, thus hindering the implementation of a building rental agreement for an event that had been made and agreed before the pandemic but its implementation during the pandemic. This research will analyze the legal protection for building tenants for delays in implementing hotel building rental agreements during the Covid-19 pandemic. The study aims to find out, review and analyze the legal protection given to tenants for delays in implementing lease agreements in the Melva Balemong Hotel & Resort building. Types of field research research, the research approach uses empirical juridical, the data needed are primary and secondary data. The results showed that legal protection is preventive and legal protection is repressive. Repressive legal protection can be provided through dispute resolution efforts that can be done through the courts and outside the court and the provision of administrative sanctions in the form of fines to the hotel. Meanwhile, preventive legal protection can be carried out to prevent arbitrary actions from the hotel that can cause losses to the tenants of the building. Legal protection based on Law Number 8 of 1999 concerning Consumer Protection can apply effectively to Melva Balemong Hotel & Resort Keywords: Lease Agreement, Covid-19, Legal ProtectionAbstrakMasa pandemi Covid-19 menyebabkan pemerintah melarang kegiatan masyarakat di luar rumah yang dimungkinkan akan menyebabkan kerumunan, sehingga menghambat suatu pelaksanaan perjanjian sewa gedung untuk suatu acara yang telah dibuat dan disepakati sebelum adanya pandemi namun pelaksanaannya pada masa pandemi. Penelitian ini akan menganalisis perlindungan hukum bagi penyewa Gedung atas Penundaan Pelaksanaan Perjanjian Sewa Gedung Hotel Pada Masa Pandemi Covid-19. Penelitian bertujuan untuk mengetahui, mengkaji dan menganalisis pelindungan hukum yang diberikan kepada penyewa atas penundaan pelaksanaan perjanjian sewa pada gedung Melva Balemong Hotel & Resort. Jenis penelitian field research, pendekatan penelitian menggunakan yuridis empiris, data yang dibutuhkan adalah data primer dan sekunder. Hasil penelitian menunjukkan bahwa perlindungan hukum secara preventif dan perlindungan hukum secara represif. Perlindungan hukum secara represif dapat diberikan melalui upaya penyelesaian sengketa yang dapat dilakukan melalui pengadilan maupun di luar pengadilan dan pemberian sanksi administratif berupa denda kepada pihak hotel. Sedangkan perlindungan hukum secara preventif dapat dilakukan untuk mencegah terjadi tindakan sewenang-wenang dari pihak hotel yang dapat menimbulkan kerugian bagi pihak penyewa gedung. Pelindungan hukum berdasarkan Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen dapat berlaku secara efektif pada Melva Balemong Hotel & Resort.
Continuous glucose monitoring has an increasing role in pre-symptomatic type 1 diabetes: advantages, limitations, and comparisons with laboratory-based testing
Authors: Joshi Kriti , Harris Mark , Cotterill Andrew , Wentworth John M. , Couper Jennifer J. , Haynes Aveni , Davis Elizabeth A. , Lomax Kate E. , Huynh Tony 
Published: June 2023

Abstract
Type 1 diabetes (T1D) is well-recognised as a continuum heralded by the development of islet autoantibodies, progression to islet autoimmunity causing beta cell destruction, culminating in insulin deficiency and clinical disease. Abnormalities of glucose homeostasis are known to exist well before the onset of typical symptoms. Laboratory-based tests such as the oral glucose tolerance test (OGTT) and glycated haemoglobin (HbA1c) have been used to stage T1D and assess the risk of progression to clinical T1D. Continuous glucose monitoring (CGM) can detect early glycaemic abnormalities and can therefore be used to monitor for metabolic deterioration in pre-symptomatic, islet autoantibody positive, at-risk individuals. Early identification of these children can not only reduce the risk of presentation with diabetic ketoacidosis (DKA), but also determine eligibility for prevention trials, which aim to prevent or delay progression to clinical T1D. Here, we describe the current state with regard to the use of the OGTT, HbA1c, fructosamine and glycated albumin in pre-symptomatic T1D. Using illustrative cases, we present our clinical experience with the use of CGM, and advocate for an increased role of this diabetes technology, for monitoring metabolic deterioration and disease progression in children with pre-symptomatic T1D.
Approximation of the stiffness of laminate stacks of electric motors subjected to cyclic loads
Authors: Szabó Viktor , Feszty Dániel , Pere Balázs 
Published: June 2023

AbstractElectric motors in automotive applications are subjected to high thermal and structural loads, while having strict requirements regarding dimensions, mass, and costs. The design of such motors requires sophisticated simulation models. The laminate stack in the rotor of such a motor is made of steel sheets and behaves transversally isotropic: the radial stiffness is equivalent to steel, and in the axial direction, it has a highly progressive nonlinear stiffness characteristic. The loading and unloading stiffness curves change from cycle to cycle when subjected to repetitive loads. In this paper, the usage of a single approximating curve to describe the longitudinal stiffness of the laminate stack is proposed. This approximation can be used in FEM models to reproduce the structural nonlinear behavior of such a laminate stack using a simpler approach than implementing the full loading and unloading curves in a material model, at a price of negligible loss of precision.
Microstructure development and mechanical behaviour of pure copper processed by the novel TWO-CAP procedure
Authors: Kaya Hasan , Uçar Mehmet , Şahbaz Mehmet , Kentli Aykut , Özbeyaz Kerim , Öğüt Serkan 
Published: June 2023

AbstractIn this study, thin-walled open channel angular pressing (TWO-CAP) technique was applied to pure copper specimens as a novel severe plastic deformation (SPD) method. The TWO-CAP process was applied to the specimens up to four passes. After each pass, the microstructural and mechanical characterization of the material was investigated by tensile and hardness tests along with OM, SEM, EDS, TEM and XRD analyses. As a result, a highly increase in the mechanical properties was obtained, in addition satisfactory grain refinement was observed in microstructures. Strength and hardness values were positively affected from the minimizing the grain sizes after TWO-CAP process. Another reason of the improvements in mechanical properties can be explained as the increase in dislocation density. Furthermore, the effect of the TWO-CAP process on the dislocation density of the material has been demonstrated by XRD and TEM analyses in nanoscale. Moreover, the strain equation has been developed analytically and the effect of each pass on strain was calculated. Finally, the effect of the process on the stress-strain properties of the material was examined by the numerical analysis method and the study was verified.
Biased processing of game-related information in problematic mobile gaming users
Authors: Bai Yu , Elhai Jon D. , Montag Christian , Yang Haibo 
Published: June 2023

AbstractBackground and aimsThe present study investigated processing bias for game-related cues in problematic mobile gamers (PMGs) under or above the threshold of conscious awareness.MethodsIn Experiment 1, all participants (20 PMGs and 23 casual players (CPs)) finished a masked visual probe task during a brief (17ms) masked exposure condition. In Experiment 2, an unmasked visual probe task was conducted by an additional forty participants (20 PMGs and 20 CPs) at two exposure durations (200 and 500ms).ResultsResults showed that PMGs, but not CPs, had an attentional bias for game-related cues which had been presented with two exposure durations (17 and 200ms).Discussion and conclusionIn conclusion, the present study provides evidence that bias in PMGs could be observed both preconsciously and consciously. The results are discussed with reference to incentive sensitization theory and automatic action schema theory.
DNA As The Determination of Descendant of Children Outside of Marriage Under The Perspective of Ibn Taimiyyah
Authors: Fageh Achmad 
Published: June 2023

The focus of this study was ibn Taimiyyah's ijtihad on the status of children outside marriage and its correlation with the determination of DNA as normative evidence of child status. The purpose of the research was to find out the results of Ibn Taimiyyah's ijtihad related to the position of children outside marriage and its correlation to the determination of DNA as a valid child status. This type of research is in the form of a literature study ijtihad Ibn Taimiyyah in Majmu' Fatawa's book using descriptive deductive analysis. The determination of child' in Islamic perspective has significant meaning, with resolution can be known relationship between child and father. His Father's decision is the first right of a child when it is born into the world that must be fulfilled. According to Ibn Taimiyyah, adulterous children can still be recognized by unfaithful men and have mahram relationships with both parents. Adulterous children have mahram relationships with the man, provided that the man realizes the adulterous child as his son. Then according to Ibn Taimiyyah's view, civil relations, both inheritance, living, and guardianship of unfaithful children with adulterous men who admit the child is severed due to adultery, Ibn Taymiyyah's opinion has a solid correlation with the verdict of Mk No. 46/PUU-VIII/2010, namely the affirmation of his father of an unmarried child having a blood relationship and civil relations with his biological father and father's family as evidenced by DNA tests. The legal relationship of an out-of-wedlock child with his biological father gives rise to the right and obligation in return.
Seismoacoustic Analysis of the Large Surface Explosion Coupling Experiment Using a Large-N Seismic Array
Authors: Chen Ting , Larmat Carene , Blom Philip , Zeiler Cleat 
Published: June 2023

ABSTRACT
Seismoacoustic signals at local distance (&lt;∼10 km) are widely used as important constraints on source parameters for near-surface events, yet the seismoacoustic wave generation and energy partitioning are not fully understood. Spatially dense sensors could provide observations in high resolution to capture the full wavefield for better understanding wave propagation and improving source estimation. Recently, spatially dense observations of the local seismoacoustic wavefield produced by a pair of 1-ton surface explosions have been recorded using a large-N seismic array. This large-N array consists of 446 geophones and covers an area of approximately 2×2.5  km2. The two surface explosions occur at the same location but at different times with different atmospheric conditions. Both seismic and air–ground coupled acoustic waves from the two surface explosions are well observed. Analyses of signals recorded by the large-N seismic array show different acoustic wave speed and amplitude for the two explosions. A strong spatial variability in acoustic wave speed and amplitude for each explosion is also observed. The observations suggest the important role of local atmosphere state on wave propagation and source estimation and demonstrate how the use of a large-N capability can improve characterization of the propagation medium and source.
Indicadores técnico-económicos de la producción del cultivo de tomate bajo agricultura protegida en la Comarca Lagunera, México
Authors: Ignacio Orona Castillo Ignacio Orona Castillo , Carmen Lizette Del-Toro-Sánchez Carmen Lizette Del-Toro-Sánchez , Manuel Fortis Hernández Manuel Fortis Hernández , Pablo Preciado Rangel Pablo Preciado Rangel , José de Jesús Espinoza Arellano José de Jesús Espinoza Arellano , Rueda Puente Edgar Omar , Misael Flores Vázquez Misael Flores Vázquez , Pedro Cano Ríos Pedro Cano Ríos 
Published: June 2023

México se encuentra en el décimo lugar a nivel mundial en la producción de tomate. La Comarca Lagunera tiene un rol importante en las exportaciones principalmente a Estados Unidos de América. Debido a la importancia económica y social en la región, el objetivo del presente estudio consistió en determinar los indicadores de productividad del agua, suelo, mano de obra y capital, lo que apoyará al productor a tomar mejores decisiones. Para realizar el estudio se seleccionaron mediante muestreo sistemático cinco unidades de producción bajo malla sombra que ocuparon el 50 % de la superficie total sembrada y por medio de una encuesta se obtuvo la información necesaria. Se encontró que el valor promedio de rendimiento fue de 11.9 kg de tomate por metro cuadrado; 54.3 kg de tomate por metro cúbico de agua, y de 61.9 y 99.7 pesos los ingresos netos obtenidos por metro cuadrado de superficie y metro cúbico de agua, respectivamente. Los mayores valores fueron registrados por las unidades de producción de mayor tamaño, concluyendo que este comportamiento obedece a la mayor economía de escala y mayor cuidado con que se maneja el cultivo.
Efficient Anthocyanin Extraction from Aqueous Mixture of Cocoa Peel Using Microwave Assisted Extraction (MAE) Method
Authors: Lutsi Nurtsulutsiyah , Yakub Hendrikson Manurung  , Istiqomah Rahmawati  
Published: June 2023

Anthocyanins are polyphenolic compounds whose existence is very abundant in nature with diversity in various types of plants. The purpose of this study was to optimize the anthocyanin extraction process from cocoa shell waste using the MAE method in order to obtain the optimum particle size, ingredient/solvent ratio, and extraction time to produce high anthocyanin concentrations. The optimized extraction process variables include size of particle (1,05; 1,25; 1,49 and 2,5 x 10-4 m), ratio of substrate/solvent (4,5; 12,5; 62,5; 79,5 x 10-3g/mL), time of extraction (2, 4, 10, 14 minutes) and microwave power (100; 275; 450; 625 watts). The Design Expert vs11 program with the Box-Behnken Design Response Surface Methodology (RSM) was used in the research and the selection of process conditions was carried out from a combination of factors that resulted in an optimal response. The relationship between variables on the modeled anthocyanin concentration response:
Y=0,000486-9,98637E-07A+0,026734B0,000041C-7,58240E-07D-0,000102AB+2,48606E-07AC+2,62878E09AD-0,000539BC+0,000012BD+9,71853E08CD

(A: particle size; B: cocoa shell:solvent ratio; C: extraction time; D: microwave power).
The optimal response value for anthocyanin concentration was 11,85.10-4 M and the conditions of extraction process are the particle size in the extraction process was 0,105 mm, the ratio of cocoa peel mass/ethanol was 0,03125 g/mL, the extraction time was 2 minutes, and the microwave power was 100 W.
Evaluation of Enhanced Oil Recovery Potential using Interfracture Water Flooding in a Tight Oil Reservoir
Authors: Yang Yi , Liao Guangzhi , Xiong Wei , Zhang Jie , Gao Shusheng , Shen Rui , Wang Shengzhou , Zhang Jianzhong , Tan Lingfang 
Published: June 2023

Abstract
The recovery factor of horizontal wells in tight reservoirs after stage fracturing is low. The effect of water huff-puff on enhancing oil recovery is not obvious. Water channeling is serious during interwell water displacement. Conventional EOR (enhance oil recovery) methods are not effective. Scholars have proposed the method of interfracture water flooding after horizontal well fracturing to improve recovery efficiency in tight reservoirs. In order to study the EOR effects of interfracture water flooding and huff-puff in tight reservoirs, three different EOR schemes were designed: interfracture synchronous water flooding (IFSWF), interfracture asynchronous water flooding (IFAWF), and water huff-puff. The experiment results show the following: (1) in the physical simulation experiment of homogeneous cores, after injection of 0.8 PV formation water, the recovery rates of huff-puff, IFAWF, and IFSWF were 25.7%, 33.7%, and 38.6%, respectively. (2) In the simulation of fractured cores, the oil concentration of IFAWF is 2.7 times higher than that of IFSWF. (3) In the simulation of formation energy replenishment by fractured core, the formation pressure increased by IFAWF is 1.9 times higher than the pressure increased by IFSWF. The results of this study show that interfracture asynchronous flooding can increase the utilization efficiency of injected water, overcome heterogeneity, effectively supplement the energy of tight reservoir, increase the swept area, and improve the recovery factor. IFAWF is a more suitable EOR method for tight reservoirs. The findings of this study contribute to a better understanding of how to select methods to enhance tight oil recovery. At the same time, it provides a method and idea for improving oil recovery of shale oil with lower reservoir physical properties.
Preoperative Thalamus Volume is not associated with preoperative cognitive impairment (preCI) or postoperative cognitive dysfunction (POCD)
Authors: Fislage Marinus , Feinkohl Insa , Borchers Friedrich , Pischon Tobias , Spies Claudia D. , Winterer Georg , Zacharias Norman , Consortium BioCog 
Published: June 2023

Abstract
Background
A growing body of literature suggests the important role of the thalamus in cognition and neurodegenerative diseases. This study aims to elucidate whether the preoperative thalamic volume is associated with preoperative cognitive impairment (preCI) and whether it is predictive for postoperative cognitive dysfunction at 3 months (POCD).
Methods
We enrolled 301 patients aged 65 or older and without signs of dementia who were undergoing elective surgery. Magnetic resonance imaging was conducted prior to surgery. Freesurfer (version 5.3.) was used to automatically segment the thalamus volume. A neuropsychological test battery was administered before surgery and at a 3 month follow-up. It included the computerized tests Paired Associate Learning (PAL), Verbal Recognition Memory (VRM), Spatial Span Length (SSP), Simple Reaction Time (SRT), the pen-and-paper Trail-Making-Test (TMT) and the manual Grooved Pegboard Test (GPT). Using a reliable change index, preCI and POCD were defined as total Z-score > 1.96 (sum score over all tests) and/or Z-scores > 1.96 in ≥ 2 individual cognitive test parameters. For statistical analyses, multivariable logistic regression models were applied. Age, sex and intracranial volume were covariates in the models.
Results
Of 301 patients who received a presurgical neuropsychological testing and MRI, 34 (11.3%) had preCI. 89 patients (29.5%) were lost to follow-up. The remaining 212 patients received a follow-up cognitive test after 3 months, of whom 25 (8.3%) presented with POCD. Independently of age, sex and intracranial volume, neither preCI (OR per cm³ increment 0.81 [95% CI 0.60–1.07] p = 0.14) nor POCD (OR 1.02 per cm³ increment [95% CI 0.75–1.40] p = 0.87) were statistically significantly associated with patients’ preoperative thalamus volume.
Conclusion
In this cohort we could not show an association of presurgical thalamus volume with preCI or POCD.
Reducing artifactual somatic variant calls from formalin-fixed paraffin-embedded specimens by using DEEPOMICSⓇ FFPE, a bioinformatic approach based on deep neural networks
Authors: Heo Dong-hyuk , Kim Inyoung , Seo Heejae , Kim Seong-Gwang , Kim Minji , Park Jiin , Park Hongsil , Kang Seungmo , Paik Soonmyung , Hong Seong-Eui 
Published: June 2023

Abstract
Formalin-fixed, paraffin-embedded (FFPE) tissue specimens are routinely used in pathological diagnosis, but their large number of artifactual mutations complicate the evaluation of companion diagnostics and analysis of next-generation sequencing data. Identification of variants with low allele frequencies is challenging because existing FFPE filtering tools label all low-frequency variants as artifacts. To address this problem, we aimed to develop DEEPOMICSⓇ FFPE, an AI model that can classify a true variant from an artifact. Paired exome genome sequencing data from fresh frozen and FFPE samples from 24 tumors were obtained from public sources and used as training and validation sets at a ratio of 7:3. A deep neural network model with three hidden layers was trained with input features using outputs of the MuTect2 caller. Contributing features were identified using the SHapley Additive exPlanations algorithm and optimized based on training results. The performance of the final model (DEEPOMICSⓇ FFPE) was compared with those of existing models (MuTect filter, FFPolish, and SOBDetector) by using well-defined test datasets. We found 43 discriminating properties for FFPE artifacts. Optimization of property quantification improved the model performance. DEEPOMICSⓇ FFPE removed 99.6% of artifacts while maintaining 85.2% of true variants, with an F1-score of 87.8 in the dataset not used for training, which is significantly higher than those of existing tools. Its performance was maintained even for low-allele-fraction variants with an specificity of 0.998, suggesting that it can be used to identify subclonal variants. Different from existing methods, DEEPOMICSⓇ FFPE identified most of the sequencing artifacts in the FFPE samples while retaining more of true variants, including those of low allele frequencies. The newly developed tool DEEPOMICSⓇ FFPE may be useful in designing capture panels for personalized circulating tumor DNA assay and identifying candidate neoepitopes for personalized vaccine design. DEEPOMICSⓇ FFPE is freely available on the web (http://deepomics.co.kr/ffpe) for research.