bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case report of coexisting transposition of the great arteries with supracardiac total anomalous pulmonary venous connection: focus on computed tomography features
Authors: Nawawi Yusuf Syaeful , Sari Indah Purnama , Maryetty Ida Prista , Rahayu Rachmi Fauziah , Widjaja Sri Lilijanti 
Published: April 2023

Abstract
Background
The coexisting of transposition of the great arteries (TGA) with total anomalous pulmonary venous connection (TAPVC) is one of the rare anomalies. The incidence of coexisting TAPVC and TGA is unknown with very few cases ever reported.

Case presentation
We reported a case of a 13-month-old female toddler with history of cyanosis. Echocardiography revealed atrioventricular ambiguity with pulmonary atresia, all PVs drain into the innominate vein via vertical vein (VV), ostium secundum atrial septal defect (ASD) and ventricular septal defect (VSD) were observed. The CT scan confirmed co-occurrence of TGA and TAPVC. All four confluence PVs behind the small left atrium (LA), drains into an ascending lateral large VV, coursing to innominate vein without any PV access into LA. The superior vena cava, right atrium and right ventricle (RV) were dilated. The RV is the origin of the aortic root. The aorta continues on the right side, with an arterial connection to the right pulmonary aberrant artery at the level of the aortic arch. Main pulmonary artery originates from LV and appears atretic with only connection to the left pulmonary artery. Large ASD and VSD were identified.

Conclusions
TGA and TAPVC are a rare combination and should be suspected in mild-cyanotic cases with levocardia with situs solitus. CT angiography is one of the modalities of choice to characterize the vasculature anomalies.
Autoregulation: mediators and renin–angiotensin system in diseases and treatments
Authors: Mansour Antony Sameh 
Published: April 2023

Abstract
Background
Hemodynamic regulation is a substantial part of the physiological integrity of the human body. It is based on the delivery of proper blood perfusion to every organ. Five primary vasoactive substances are nearly located throughout the human body, either released from the endothelium, prostanoids, nitric oxide (NO), and endothelin-1 (ET-1); or considered as hormones, bradykinin (BK) and natriuretic peptides (NPs).

Main body
The circulating mediators are in synchronization with the renin–angiotensin system (RAS) during the pathogenesis of the main vital organs, heart, kidney, lung, liver, and brain. The RAS system has been an extensive therapeutic approach for cardiovascular and renal diseases for decades, but more recently became a crucial regulator of hemodynamics in other organs after the actions of its components were detected in other organs. All the mentioned disorders here begin with the initiation of abnormal imbalance between vasoactive mediators which causes vascular dysfunction and histopathological situations that may induce oxidative stress which exaggerates the disorder if there is no clinical intervention.

Conclusion
We will review the currently identified signaling pathways and the possible relationships between those compounds elucidating how they interfere with serious diseases including cardiovascular diseases (CVDs), chronic kidney disease (CKD), pulmonary arterial hypertension (PAH), portal hypertension (PHT), and Alzheimer's disease (AD). Thus, this updated review summarizes years of work that aims to define the contribution of each mediator in both normal and pathological states, besides the drugs based on their activity and their places in either preclinical or clinical trials.
Ultrasensitive Circulating Tumor DNA Pilot Study Distinguishes Complete Response and Partial Response With Immunotherapy in Patients With Metastatic Renal Cell Carcinoma
Authors: Chehrazi-Raffle Alexander , Muddasani Ramya , Dizman Nazli , Hsu JoAnn , Meza Luis , Zengin Zeynep B. , Malhotra Jasnoor , Chawla Neal , Dorff Tanya , Contente-Cuomo Tania , Dinwiddie Devin , McDonald Bradon R. , McDaniel Timothy , Trent Jeffrey M. , Baehner Frederick L. , Murtaza Muhammed , Pal Sumanta K. 
Published: April 2023

PURPOSE Circulating tumor DNA (ctDNA) has been validated across multiple indications in the adjuvant and surveillance settings. We evaluated whether targeted digital sequencing (TARDIS) may distinguish a partial response (PR) from a complete response (CR) among patients with metastatic renal cell carcinoma (mRCC) receiving immune checkpoint inhibitor (ICI) therapy. MATERIALS AND METHODS Eligible patients had mRCC that yielded a PR or CR to ICI therapy. Peripheral blood was obtained at a single time point for ctDNA analysis. TARDIS was used for quantification of average variant allele fractions (VAFs). Our primary objective was to determine the association between VAFs and depth of response (PR v CR). A secondary objective was to determine whether VAFs were associated with disease progression. RESULTS Twelve patients were analyzed, nine of whom achieved a PR (75%). Patients received either nivolumab monotherapy (50%) or nivolumab plus ipilimumab (50%). ctDNA analysis incorporated an average of 30 patient-specific mutations (range, 19-35); average coverage depth was 103,342 reads per target. TARDIS quantified a significant difference in VAFs between PR and CR (median, 0.181% [IQR, 0.077%-0.420%] v 0.007% [IQR, 0.0%-0.028%], respectively [ P = .014]). Of the 12 patients in the series, six patients demonstrated radiographic progression subsequent to ctDNA assessment. Patients who progressed on subsequent scans had significantly higher ctDNA than those who maintained their response (median, 0.362% [IQR, 0.181%-2.71%] v 0.033% [IQR, 0.007%-0.077%], respectively [ P = .026]). CONCLUSION In this pilot study, TARDIS accurately differentiated PR from CR among patients with mRCC receiving immunotherapy, and also prospectively identified patients at risk for subsequent progression. Given these findings, we envision subsequent studies that validate these results and investigate the utility of this assay to discern appropriate candidates for discontinuation of immunotherapy.
Pertuzumab Plus Trastuzumab in Patients With Endometrial Cancer With ERBB2/3 Amplification, Overexpression, or Mutation: Results From the TAPUR Study
Authors: Ahn Eugene R. , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Ali-Ahmad Hussein M. , Chan John , Maitland Michael L. , Patel Sapna R. , Reese Zachary , Balmanoukian Ani S. , Drescher Charles W. , Li Rui , Tsimberidou Apostolia M. , Leath Charles A. , O'Lone Raegan , Grantham Gina N. , Halabi Susan , Schilsky Richard L. 
Published: April 2023

PURPOSE The TAPUR Study is a pragmatic basket trial evaluating antitumor activity of commercially available targeted agents in patients with advanced cancers harboring potentially actionable genomic alterations. Data from a cohort of patients with endometrial cancer (EC) with ERBB2 or ERBB3 (ERBB2/3) amplification, overexpression, or mutation treated with pertuzumab plus trastuzumab (P + T) are reported. METHODS Eligible patients had advanced EC, no standard treatment options, measurable disease (RECIST v1.1), Eastern Cooperative Oncology Group performance status 0-2, adequate organ function, and tumors with ERBB2/3 amplification, overexpression, or mutation. Simon's two-stage design was used with a primary end point of disease control (DC), defined as objective response (OR) or stable disease (SD) of at least 16 weeks (SD16+) duration. Secondary end points include safety, duration of response, duration of SD, progression-free survival (PFS), and overall survival (OS). RESULTS Twenty-eight patients were enrolled from March 2017 to November 2019; all patients were evaluable for efficacy and toxicity. Seventeen patients had tumors with ERBB2/3 amplification and/or overexpression, eight with both ERBB2 amplification and ERBB2/3 mutations, and three with only ERBB2 mutations. Ten patients had DC (two partial response and eight SD16+); all 10 had ERBB2 amplification, and 6 of the 10 patients with DC had >1 ERBB2/3 alteration. DC and OR rates were 37% (95% CI, 21 to 50) and 7% (95% CI, 1 to 24), respectively; the median PFS and median OS were 16 weeks (95% CI, 10-28) and 61 weeks (95% CI, 24-105), respectively. One patient experienced a grade 3 serious adverse event (muscle weakness) at least possibly related to P + T. CONCLUSION P + T has antitumor activity in heavily pretreated patients with EC with ERBB2 amplification and warrants additional study.
Consistent Exercise Timing as a Strategy to Increase Physical Activity: A Feasibility Study
Authors: Schumacher Leah M. , Kalala Siddhartha , Thomas J. Graham , Raynor Hollie A. , Rhodes Ryan E. , Bond Dale S. 
Published: April 2023

ABSTRACT

Introduction/Purpose
Observational research suggests that consistent exercise timing could be leveraged to promote moderate to vigorous physical activity (MVPA) among adults with obesity. However, the feasibility and acceptability of prescribed consistent exercise timing in a free-living setting is unknown. The purpose of this study was to assess the feasibility and acceptability of prescribed consistent exercise timing in a free-living setting among inactive adults with obesity (primary) and to compare MVPA timing prescription and characterize barriers/facilitators (secondary).

Methods
Using a within-subjects design, inactive adults with obesity (n = 15) were randomized in a counterbalanced order to three 3-wk exercise timing conditions separated by 2-wk washout periods: 1) consistent morning, 2) consistent evening, and 3) choice timing (control). Feasibility was assessed using prespecified benchmarks. Acceptability and preferred timing were assessed with questionnaires postintervention. Secondarily, exercise timing and MVPA were assessed via accelerometry, and nightly surveys and barriers/facilitators were assessed with nightly surveys.

Results
All feasibility benchmarks were achieved (e.g., timing adherence = 69.9% via accelerometry and 87.4% via self-report; target, ≥60%). Consistent exercise timing was acceptable (mean rating = 3.7 of 5; target, ≥3.5). Choice was the most popular prescription. There were medium- to large-sized effects (partial η
2 of 0.09–0.16) of condition on MVPA; MVPA was higher during the morning and the evening conditions versus choice condition. Facilitators were similar across conditions, whereas some barriers were time specific.

Conclusion
Prescribed exercise timing in a free-living setting appears feasible and acceptable. Although choice timing was most preferred, consistent timing appeared most effective for increasing MVPA. Data warrant larger trials to test the efficacy and mechanisms of consistent exercise timing as a translational strategy for promoting MVPA. Pending findings from a fully powered randomized trial, practitioners interested in promoting MVPA among their patients or clients could consider encouraging exercise at a consistent time day to day.
THE MEMORY OF THE BODY AS TRANSPERSONAL ARCHETYPE
Authors: Lucaciu Adriana 
Published: April 2023

The paper proposes a perspective based on a research through art at the crossroads between personal memory, corporeality, transpersonal archetypes and drawing. If art can be admitted as a way of ‘writing’ through images, self-reflexive art can be considered a self-description, as well as an ‘autograph’, which is not reduced to affectivity. From here it is only a step to notice that the ‘disguised’ revelation of the self as our memory archived it, by artistic works, turns out to be a symbolic narrative, expressed through metaphors with autobiographical overtones. The artistic act placed outside of creation in relation to the evaluative factors, is exempt from gratuity because it responds to at least one existential need – that of self-expression, which becomes paramount in historical, social and private history contexts. It plays a main role in documenting actual life and preserving it for the future, like reveries of dissolution and permanence.
Long-COVID, neurological and cardiovascular disorders
Authors: Saienko Oleksandr , Chemych Mykola , Svitailo Vladyslav 
Published: April 2023

Introduction. After the disease COVID-19 caused by the SARS-CoV-2 virus, many people recover completely, but others have symptoms that persist for weeks, months or even years after the illness, with the number of patients who are worried about the signs of Long-COVID constantly growing.
The aim. Study of the features of the epidemiological and clinical course, pathophysiological mechanisms of long-COVID development, based on the study and analysis of modern scientific data and the establishment of causal relationships of damage to the nervous and cardiovascular systems.
Materials and methods. The electronic databases Scopus, PubMed, Web of Science, using modern technologies (Obsidian), key terms and words related to Long COVID, distant neurological and cardio-vascular complications have been studied and analyzed.
Conclusions. "Long COVID" is conceptualized as a multiorgan disorder with a wide range of clinical signs that may indicate primarily damage to the nervous and cardiovascular systems. Central or peripheral nervous system lesions occur in more than one-third of patients. Cardiovascular complications, including stroke, are the predominant causes of death of people with "long COVID" (40 %). The most frequent neurological signs of "Long COVID" (>70 %) are fatigue, headache, sleep disorders, emotional disorders and sensorimotor disorders. The processes of neuroinflammatory and oxidative stress predominate in the spread of neurological consequences of "Long COVID".
Tax Planning Knowledge Diffusion via the Labor Market
Authors: Barrios John M. , Gallemore John 
Published: April 2023

We examine the extent to which the labor market facilitates the diffusion of tax-planning knowledge across firms. Using a novel data set of tax department employee movements between S&P 1500 firms, we find that firms experience an increase in their tax planning after hiring a tax employee from a tax-aggressive firm. This finding is robust to various research designs and specifications. Consistent with tax-planning knowledge driving the result, we find that the tax-planning benefits are more substantial when the employee is involved in a director-level role and has more experience. Further tests suggest that tax-planning knowledge is highly specific in nature: the increase in tax avoidance is larger when the hiring and former firms are similar (i.e., operating in the same sector or having similar foreign operations), and firms are more likely to hire tax department employees from firms with similar characteristics. Finally, we do not find that the prior firm’s tax planning changes after the employee leaves the firm, suggesting that the tax-planning knowledge simply spreads to the hiring firm and does not leave the prior firm. Our study documents the first order role of the labor market in the diffusion of tax-planning knowledge across firms, and our findings suggest that tax department human capital is a central determinant of tax-planning outcomes. This paper was accepted by Suraj Srinivasan, accounting. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4741 .
Implementation of a midline catheter service in a regional setting
Authors: Jones Paul 
Published: April 2023

Introduction: Midline catheters have been reported to be an effective and safe means of providing patients with intravenous access within the hospital and community setting. With minimal experience in the introduction of a midline service across the local health network, a regional hospital pursued this task. This observational study assesses the provision of a safe clinical framework for midline insertion, and the improvement of patient care and experiences by avoiding treatment interruptions and unnecessary cannulation attempts from failed traditional peripheral vascular access devices. Methods: From the introduction of the midline service in June 2018, outcome measures of all patients who received a midline over the following two-year period were documented including rate of line success, complication rates, dwell time, and the number of insertion attempts. Results: The midline service provided 207 lines over a two-year period with a total dwell time of 1,585 days. Project goals were achieved with 85% (Aim > 85%) of all lines completing treatment prior to removal. First attempt insertion was 86% (Aim > 80%) with a maximum insertion attempt of two. Rates of line-related complications were less than 8%, with five documented cases of phlebitis (2.5%) and one deep vein thrombosis with no infections documented. Conclusion: Despite limited resources, a successful midline service was introduced. Future expansion will see an increase in insertor numbers providing improved access to the service.
Near-infrared spectroscopy for structural bone assessment
Authors: Sharma Varun J. , Adegoke John A. , Afara Isaac O. , Stok Kathryn , Poon Eric , Gordon Claire L. , Wood Bayden R. , Raman Jaishankar 
Published: April 2023

AimsDisorders of bone integrity carry a high global disease burden, frequently requiring intervention, but there is a paucity of methods capable of noninvasive real-time assessment. Here we show that miniaturized handheld near-infrared spectroscopy (NIRS) scans, operated via a smartphone, can assess structural human bone properties in under three seconds.MethodsA hand-held NIR spectrometer was used to scan bone samples from 20 patients and predict: bone volume fraction (BV/TV); and trabecular (Tb) and cortical (Ct) thickness (Th), porosity (Po), and spacing (Sp).ResultsNIRS scans on both the inner (trabecular) surface or outer (cortical) surface accurately identified variations in bone collagen, water, mineral, and fat content, which then accurately predicted bone volume fraction (BV/TV, inner R2= 0.91, outer R2= 0.83), thickness (Tb.Th, inner R2= 0.9, outer R2= 0.79), and cortical thickness (Ct.Th, inner and outer both R2= 0.90). NIRS scans also had 100% classification accuracy in grading the quartile of bone thickness and quality.ConclusionWe believe this is a fundamental step forward in creating an instrument capable of intraoperative real-time use.Cite this article:Bone Jt Open 2023;4(4):250–261.
Clinical frailty is independently associated with joint-specific function and health-related quality of life in patients awaiting a total hip or knee arthroplasty
Authors: Bayram John M. , Wickramasinghe Neil R. , Scott Chloe E. H. , Clement Nick D. 
Published: April 2023

AimsThe aims were to assess whether preoperative joint-specific function (JSF) and health-related quality of life (HRQoL) were associated with level of clinical frailty in patients waiting for a primary total hip arthroplasty (THA) or knee arthroplasty (KA).MethodsPatients waiting for a THA (n = 100) or KA (n = 100) for more than six months were prospectively recruited from the study centre. Overall,162 patients responded to the questionnaire (81 THA; 81 KA). Patient demographics, Oxford score, EuroQol five-dimension (EQ-5D) score, EuroQol visual analogue score (EQ-VAS), Rockwood Clinical Frailty Score (CFS), and time spent on the waiting list were collected.ResultsThere was a significant correlation between CFS and the Oxford score (THA r = −0.838; p < 0.001, KA r = −0.867; p < 0.001), EQ-5D index (THA r = −0.663, p =< 0.001; KA r = −0.681; p =< 0.001), and EQ-VAS (THA r = −0.414; p < 0.001, KA r = −0.386; p < 0.001). Confounding variables (demographics and waiting time) where adjusted for using multiple regression analysis. For each 8.5 (THA, 95% CI 7.1 to 10.0; p < 0.001) and 9.9 (KA, 95% CI 8.4 to 11.4; p < 0.001) point change in the Oxford score, there was an associated change in level of the CFS. For each 0.16 (THA, 95% CI 0.10 to 0.22; p < 0.001) and 0.20 (KA, 95% CI 0.12 to 0.27; p < 0.001) utility change in EQ-5D, there was an associated change in level of the CFS. EQ-VAS (THA, B = −11.5; p < 0.001, KA B = −7.9; p = 0.005) was also associated with CFS.ConclusionJSF and HRQoL in patients awaiting THA or KA for more than six months, were independently associated with level of clinical frailty. With further prospective studies, clinical frailty may prove to be a useful metric to assist in the prioritization of arthroplasty waiting lists.Cite this article: Bone Jt Open 2023;4(4):241–249.
408  Gbit/s PAM-8 sidewall-doped germanium–silicon photodetector
Authors: Hu Xiao , Wu Dingyi , Liu Ye , Chen Daigao , Wang Lei , Xiao Xi , Yu Shaohua 
Published: April 2023

Based on the 90 nm silicon photonics commercial foundry, sidewall-doped germanium–silicon photodetectors (PDs) are designed and fabricated. The large designed overlap between the optical field and electric field achieves high responsivity while retaining high-speed performance. Even including the loss due to optical fiber coupling, the PD demonstrates an external responsivity greater than 0.55 A/W for transverse magnetic (TM) polarization and 0.65 A/W for transverse electric (TE) polarization at 1530 nm. A flat responsivity spectrum of >0.5  A/W is achieved up to 1580 nm for both polarizations. Their internal responsivities can exceed 1 A/W in the C+L optical communication bands. Furthermore, with the aid of a 200 mm wafer-level test and analysis, the overall PDs of 26 reticles have a 3 dB optoelectrical bandwidth >50  GHz and a dark current <10  nA at a −3  V bias voltage. Finally, the eye diagram performances under TE and TM polarizations, various modulation formats, and different input wavelengths are comprehensively investigated. The clear open electrical eye diagrams up to 120, 130, 140, and 150 Gbit/s nonreturn-to-zero are experimentally attained at a photocurrent of 1 mA. To the best of our knowledge, this is the first time that single-lane direct detection of record-high-speed 200, 224, 256, and 290 Gbit/s four-level pulse amplitude modulation (PAM) and 300, 336, 384, and 408 Gbit/s eight-level PAM optical signals has been experimentally achieved.