bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity Analysis for Survey Weights
Authors: Hartman Erin , Huang Melody 
Published: April 2023

AbstractSurvey weighting allows researchers to account for bias in survey samples, due to unit nonresponse or convenience sampling, using measured demographic covariates. Unfortunately, in practice, it is impossible to know whether the estimated survey weights are sufficient to alleviate concerns about bias due to unobserved confounders or incorrect functional forms used in weighting. In the following paper, we propose two sensitivity analyses for the exclusion of important covariates: (1) a sensitivity analysis for partially observed confounders (i.e., variables measured across the survey sample, but not the target population) and (2) a sensitivity analysis for fully unobserved confounders (i.e., variables not measured in either the survey or the target population). We provide graphical and numerical summaries of the potential bias that arises from such confounders, and introduce a benchmarking approach that allows researchers to quantitatively reason about the sensitivity of their results. We demonstrate our proposed sensitivity analyses using state-level 2020 U.S. Presidential Election polls.
A careful consideration of CLARIFY: simulation-induced bias in point estimates of quantities of interest
Authors: Rainey Carlisle 
Published: April 2023

AbstractSome work in political methodology recommends that applied researchers obtain point estimates of quantities of interest by simulating model coefficients, transforming these simulated coefficients into simulated quantities of interest, and then averaging the simulated quantities of interest (e.g., CLARIFY). But other work advises applied researchers to directly transform coefficient estimates to estimate quantities of interest. I point out that these two approaches are not interchangeable and examine their properties. I show that the simulation approach compounds the transformation-induced bias identified by Rainey (2017), adding bias with direction and magnitude similar to the transformation-induced bias. I refer to this easily avoided additional bias as “simulation-induced bias.” Even if researchers use simulation to estimate standard errors, they should directly transform maximum likelihood estimates of coefficient estimates to obtain point estimates of quantities of interest.
On ρ-conjugate Hopf–Galois structures
Authors: Truman Paul J. 
Published: April 2023

AbstractThe Hopf–Galois structures admitted by a Galois extension of fields $ L/K $ with Galois group G correspond bijectively with certain subgroups of $ \mathrm{Perm}(G) $. We use a natural partition of the set of such subgroups to obtain a method for partitioning the set of corresponding Hopf–Galois structures, which we term ρ-conjugation. We study properties of this construction, with particular emphasis on the Hopf–Galois analogue of the Galois correspondence, the connection with skew left braces, and applications to questions of integral module structure in extensions of local or global fields. In particular, we show that the number of distinct ρ-conjugates of a given Hopf–Galois structure is determined by the corresponding skew left brace, and that if $ H, H^{\prime} $ are Hopf algebras giving ρ-conjugate Hopf–Galois structures on a Galois extension of local or global fields $ L/K $ then an ambiguous ideal $ \mathfrak{B} $ of L is free over its associated order in H if and only if it is free over its associated order in Hʹ. We exhibit a variety of examples arising from interactions with existing constructions in the literature.
Causality and the Procession of the Holy Spirit in Manuel Kalekas’s De fide deque principiis catholicae fidei
Authors: Lynch Reginald M. 
Published: April 2023

AbstractThis article examines the way in which Manuel Kalekas describes the procession of the trinitarian persons in one of his earliest systematic treatises. As a member of so-called “Kydones circle,” Kalekas was part of a fourteenth-century group of Latinophrone Byzantine theologians who were interested in ecclesial union with the Latin West and in Latin theological sources. In addition to certain texts from Augustine, during the fourteenth century several works by Thomas Aquinas became available in Greek translation. Kalekas’s De fide is of interest because it integrates conceptual and structural insights from Aquinas even as it draws on Greek traditions from Cappadocia and Byzantium. Although the importance of Aquinas’s Summa contra gentiles for the work of the Kydones circle is often cited, this article argues that Aquinas’s Summa theologiae was also a significant influence for Kalekas.
Fragmented but Enduring Authoritarianism: Supply-side Reform and Subnational Entrepreneurialism in China's Rail Delivery Services
Authors: Tjia Linda Yin-nor 
Published: April 2023

AbstractChina's economic reform since 1978 has turned a shortage economy into an economy of overcapacity. To curb the capacity surplus, the government put forward a sweeping proposal of “supply-side structural reform,” although without any specifics of implementation. This vagueness has resulted in fragmentation between China's central leadership and local agents. Based on two rail delivery services – China Railway Express Delivery (Zhongtie kuaiyun 中铁快运, CRED) and China–Europe Rail Freight (Zhong–Ou banlie 中欧班列, CERF) – this article argues that fragmentation in authority has allowed and even encouraged local actors to carve profit-making opportunities out of the excess capacities (including idle assets). In so doing, they give substance to what would otherwise be hollow policy rhetoric. Such subnational entrepreneurialism and the resulting tacit dynamics between state and local-level actors add another layer to the fine-grained theorization of fragmented authoritarianism in China: despite fragmentation, China's authoritarian governance endures, but with outcomes now shaped by a cyclical process of decentralization and re-centralization as well as continuous central–local interplay.
Coherent differentiation
Authors: Ehrhard Thomas 
Published: April 2023

AbstractThe categorical models of differential linear logic (LL) are additive categories and those of the differential lambda-calculus are left-additive categories because of the Leibniz rule which requires the summation of two expressions. This means that, as far as the differential lambda-calculus and differential LL are concerned, these models feature finite nondeterminism and indeed these languages are essentially non-deterministic. We introduce a categorical framework for differentiation which does not require additivity and is compatible with deterministic models such as coherence spaces and probabilistic models such as probabilistic coherence spaces.
Training and development experiences of nursing associate trainees based in primary care across England: a qualitative study
Authors: King Rachel , Laker Sara , Alden Sarah , Ryan Tony , Wood Emily , Tod Angela , Senek Michaela , Taylor Bethany , Robertson Steven 
Published: April 2023

Abstract

Background:
The nursing associate role was first deployed in England in 2019 to fill a perceived skills gap in the nursing workforce between healthcare assistants and registered nurses and to offer an alternative route into registered nursing. Initially, trainee nursing associates were predominantly based in hospital settings; however, more recently, there has been an increase in trainees based in primary care settings. Early research has focussed on experiences of the role across a range of settings, particularly secondary care; therefore, little is known about the experiences and unique support needs of trainees based in primary care.

Aim:
To explore the experiences and career development opportunities for trainee nursing associates based in primary care.

Methods:
This study used a qualitative exploratory design. Semi-structured interviews were undertaken with 11 trainee nursing associates based in primary care from across England. Data were collected between October and November 2021, transcribed and analysed thematically.

Findings:
Four key themes relating to primary care trainee experiences of training and development were identified. Firstly, nursing associate training provided a ‘valuable opportunity for career progression’. Trainees were frustrated by the ‘emphasis on secondary care’ in both academic content and placement portfolio requirements. They also experienced ‘inconsistency in support’ from their managers and assessors and noted a number of ‘constraints to their learning opportunities’, including the opportunity to progress to become registered nurses.

Conclusion:
This study raises important issues for trainee nursing associates, which may influence the recruitment and retention of the nursing associate workforce in primary care. Educators should consider adjustments to how the curriculum is delivered, including primary care skills and relevant assessments. Employers need to recognise the resource requirements for the programme, in relation to time and support, to avoid undue stress for trainees. Protected learning time should enable trainees to meet the required proficiencies.
Disentangling the Link between Diverse Social Networks and Creativity: The Role of Personality Traits
Authors: Soler-Pastor Elia , Bobowik Magdalena , Benet-Martínez Verónica , Repke Lydia 
Published: April 2023

AbstractPast studies have shown that being exposed to ethnocultural diversity can positively impact individual creativity. Yet, little is known about the interplay between situational (i.e., diversity) and dispositional (e.g., personality) factors in predicting creativity. Taking a person-situation approach, we use social network data to test the moderating role of personality in the relationship between having an ethnoculturally diverse network and creativity. Moreover, we investigate these questions in a diverse community sample of immigrants residing in the city of Barcelona (N= 122). Moderation analyses revealed that network diversity predicted higher levels of creativity in migrant individuals with medium to high levels of extraversion, and in those with low to medium levels of emotional stability. These results highlight the need to acknowledge the important role played by interacting individual-level dispositions and more objective meso-level contextual conditions in explaining one’s ability to think creatively, especially in samples that have traditionally been underrepresented in previous literature.
Nondestructive monitoring of annealing and chemical–mechanical planarization behavior using ellipsometry and deep learning
Authors: Sun Qimeng , Yang Dekun , Liu Tianjian , Liu Jianhong , Wang Shizhao , Hu Sizhou , Liu Sheng , Song Yi 
Published: April 2023

AbstractThe Cu-filling process in through-silicon via (TSV-Cu) is a key technology for chip stacking and three-dimensional vertical packaging. During this process, defects resulting from chemical–mechanical planarization (CMP) and annealing severely affect the reliability of the chips. Traditional methods of defect characterization are destructive and cumbersome. In this study, a new defect inspection method was developed using Mueller matrix spectroscopic ellipsometry. TSV-Cu with a 3-μm-diameter and 8-μm-deep Cu filling showed three typical types of characteristics: overdishing (defect-OD), protrusion (defect-P), and defect-free. The process dimension for each defect was 13 nm. First, the three typical defects caused by CMP and annealing were investigated. With single-channel deep learning and a Mueller matrix element (MME), the TSV-Cu defect types could be distinguished with an accuracy rate of 99.94%. Next, seven effective MMEs were used as independent channels in the artificial neural network to quantify the height variation in the Cu filling in the z-direction. The accuracy rate was 98.92% after training, and the recognition accuracy reached 1 nm. The proposed approach rapidly and nondestructively evaluates the annealing bonding performance of CMP processes, which can improve the reliability of high-density integration.
Monkeypox virus quadrivalent mRNA vaccine induces immune response and protects against vaccinia virus
Authors: Sang Ye , Zhang Zhen , Liu Fan , Lu Haitao , Yu Changxiao , Sun Huisheng , Long Jinrong , Cao Yiming , Mai Jierui , Miao Yiqi , Wang Xin , Fang Jiaxin , Wang Youchun , Huang Weijin , Yang Jing , Wang Shengqi 
Published: April 2023

AbstractMonkeypox has been declared a public health emergency by the World Health Organization. There is an urgent need for efficient and safe vaccines against the monkeypox virus (MPXV) in response to the rapidly spreading monkeypox epidemic. In the age of COVID-19, mRNA vaccines have been highly successful and emerged as platforms enabling rapid development and large-scale preparation. Here, we develop two MPXV quadrivalent mRNA vaccines, named mRNA-A-LNP and mRNA-B-LNP, based on two intracellular mature virus specific proteins (A29L and M1R) and two extracellular enveloped virus specific proteins (A35R and B6R). By administering mRNA-A-LNP and mRNA-B-LNP intramuscularly twice, mice induce MPXV specific IgG antibodies and potent vaccinia virus (VACV) specific neutralizing antibodies. Further, it elicits efficient MPXV specific Th-1 biased cellular immunity, as well as durable effector memory T and germinal center B cell responses in mice. In addition, two doses of mRNA-A-LNP and mRNA-B-LNP are protective against the VACV challenge in mice. And, the passive transfer of sera from mRNA-A-LNP and mRNA-B-LNP-immunized mice protects nude mice against the VACV challenge. Overall, our results demonstrate that mRNA-A-LNP and mRNA-B-LNP appear to be safe and effective vaccine candidates against monkeypox epidemics, as well as against outbreaks caused by other orthopoxviruses, including the smallpox virus.
Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study
Authors: Chin Fatt Cherise R. , Asbury Sarah , Jha Manish K. , Minhajuddin Abu , Sethuram Sangita , Mayes Taryn , Kennedy Sidney H. , Foster Jane A. , Trivedi Madhukar H. 
Published: April 2023

AbstractAlterations in the gut microbiome have been linked to a variety of mental illnesses including anxiety and depression. This study utilized advanced bioinformatics tools that integrated both the compositional and community nature of gut microbiota to investigate how gut microbiota influence clinical symptoms in a sample of participants with depression. Gut microbiota of 179 participants with major depressive disorder (MDD) in the Texas Resilience Against Depression (T-RAD) study were analyzed by 16S rRNA gene sequencing of stool samples. Severity of anxiety, depression, and anhedonia symptoms were assessed with General Anxiety Disorder – 7 item scale, Patient Health 9-item Questionnaire, and Dimensional Anhedonia Rating Scale, respectively. Using weighted correlation network analysis, a data-driven approach, three co-occurrence networks of bacterial taxa were identified. One of these co-occurrence networks was significantly associated with clinical features including depression and anxiety. The hub taxa associated with this co-occurrence module –one Ruminococcaceae family taxon, one Clostridiales vadinBB60 group family taxon, and one Christencenellaceae family taxon– were connected to several additional butyrate-producing bacteria suggesting that deficits in butyrate production may contribute to clinical symptoms. Therefore, by considering the community nature of the gut microbiome in a real world clinical sample, this study identified a gut microbial co-occurrence network that was significantly associated with clinical anxiety in a cohort of depressed individuals.
Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
Authors: Zhong Fengyun , Lin Yilin , Zhao Long , Yang Changjiang , Ye Yingjiang , Shen Zhanlong 
Published: April 2023

AbstractIn recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers, especially those non-tumour components such as immune cells. Infiltration of various immune cells causes tumour immune microenvironment (TIME) heterogeneity, and results in different therapeutic effects. Accumulating evidence showed that DNA methylation plays a crucial role in remodelling TIME and is associated with the response towards immune checkpoint inhibitors (ICIs). During carcinogenesis, DNA methylation profoundly changes, specifically, there is a global loss of DNA methylation and increased DNA methylation at the promoters of suppressor genes. Immune cell differentiation is disturbed, and exclusion of immune cells from the TME occurs at least in part due to DNA methylation reprogramming. Therefore, pharmaceutical interventions targeting DNA methylation are promising. DNA methyltransferase inhibitors (DNMTis) enhance antitumor immunity by inducing transcription of transposable elements and consequent viral mimicry. DNMTis upregulate the expression of tumour antigens, mediate immune cells recruitment and reactivate exhausted immune cells. In preclinical studies, DNMTis have shown synergistic effect when combined with immunotherapies, suggesting new strategies to treat refractory solid tumours.
KDM4C silencing inhibits cell migration and enhances radiosensitivity by inducing CXCL2 transcription in hepatocellular carcinoma
Authors: Zeng Zhen , Li Zixuan , Xue Jun , Xue Huichan , Liu Zhiwei , Zhang Wenxuan , Liu Hongli , Xu Shuangbing 
Published: April 2023

AbstractKDM4C, which is a histone lysine demethylase, has been proposed to participate in the malignant transformation and progression of several types of cancer. However, its roles in hepatocellular carcinoma (HCC) remain poorly understood. Here, we find that KDM4C protein expression is increased in HCC and promotes HCC cell growth, proliferation and migration. Furthermore, we provide evidence that depletion of KDM4C leads to a defective G2/M checkpoint, increases radiation-induced DNA damage, impairs DNA repair and enhances radiosensitivity in HCC cells. Using RNA sequencing, we identify that the chemokine CXCL2 is a downstream effector of KDM4C. KDM4C knockdown increases the binding of H3K36me3 to the promoter of CXCL2, thus upregulating CXCL2 expression and promoting CXCL2 secretion in HCC cells. Importantly, the observed effects of KDM4C depletion in HCC cells can be partially rescued by CXCL2 silencing. Thus, our findings reveal that KDM4C is involved in cell migration and radiosensitivity by modulating CXCL2 transcription, indicating that KDM4C may be a potential therapeutic target in HCC.
MSI2 promotes translation of multiple IRES-containing oncogenes and virus to induce self-renewal of tumor initiating stem-like cells
Authors: Yeh Da-Wei , Zhao Xuyao , Siddique Hifzur R. , Zheng Mengmei , Choi Hye Yeon , Machida Tatsuya , Narayanan Padmini , Kou Yi , Punj Vasu , Tahara Stanley M. , Feldman Douglas E. , Chen Lin , Machida Keigo 
Published: April 2023

Abstract
RNA-binding protein Musashi 2 (MSI2) is elevated in several cancers and is linked to poor prognosis. Here, we tested if MSI2 promotes MYC and viral mRNA translation to induce self-renewal via an internal ribosome entry sequence (IRES). We performed RIP-seq using anti-MSI2 antibody in tumor-initiating stem-like cells (TICs). MSI2 binds the internal ribosome entry site (IRES)-containing oncogene mRNAs including MYC, JUN and VEGFA as well as HCV IRES to increase their synthesis and promote self-renewal and tumor-initiation at the post-transcriptional level. MSI2 binds a lncRNA to interfere with processing of a miRNA that reduced MYC translation in basal conditions. Deregulation of this integrated MSI2-lncRNA-MYC regulatory loop drives self-renewal and tumorigenesis through increased IRES-dependent translation of MYC mRNA. Overexpression of MSI2 in TICs promoted their self-renewal and tumor-initiation properties. Inhibition of MSI2-RNA binding reduced HCV IRES activity, viral replication and liver hyperplasia in humanized mice predisposed by virus infection and alcohol high-cholesterol high-fat diet. Together MSI2, integrating the MYC oncogenic pathway, can be employed as a therapeutic target in the treatment of HCC patients.
Macrophages mediate psoriasis via Mincle-dependent mechanism in mice
Authors: Tan Rui-zhi , Zhong Xia , Han Rang-yue , Xie Ke-huan , Jia Jian , Yang Ye , Cheng Mei , Yang Chun-yan , Lan Hui-yao , Wang Li 
Published: April 2023

AbstractPsoriasis is currently considered to be an immune and inflammatory disease characterized by massive immune cells infiltration including macrophages. It has been reported that macrophage-inducible C-type lectin (Mincle) is essential to maintain the pro-inflammatory phenotype of M1 macrophages, however, its role and mechanisms in psoriasis remain largely unknown. A model of psoriasis was induced in mice by a daily topical application of imiquimod for 7 days. Role and mechanisms of Mincle in macrophage-mediated psoriasis were investigated in clodronate liposomes induced macrophage depletion mice followed by adoptively transferring with Mincle-expressing or -knockout (KO) macrophages, and in macrophage specific Mincle knockout mice (Mincleloxp/loxp/Lyz2-cre+/+). Finally, a Mincle neutralizing antibody was employed to the psoriasis mice to reveal the therapeutic potential for psoriasis by targeting Mincle. Mincle was highly expressed by M1 macrophages in the skin lesions of patients and mice with psoriasis. Clodronate liposomes-induced macrophage depletion inhibited psoriasis in mice, which was restored by adoptive transfer with Mincle-expressing macrophages but not by Mincle-KO macrophages. This was further confirmed in macrophage-specific Mincle-KO mice. Mechanistically, macrophages mediated psoriasis via the Mincle-Syk-NF-κB pathway as blocking macrophage Mincle inhibited Syk/NF-κB-driven skin lesions and epidermal injury in vivo and in vitro. We also found that LPS induced Mincle expression by M1 macrophages via the PU.1-dependent mechanism. Most importantly, we revealed that targeting Mincle with a neutralizing antibody significantly improved psoriasis in mice. In summary, our findings demonstrated that macrophages mediate psoriasis in mice via the Mincle-dependent mechanism, targeting Mincle may represent as a novel therapy for psoriasis.
An aptamer-based depot system for sustained release of small molecule therapeutics
Authors: Wang Dali , Li Yang , Deng Xiaoran , Torre Matthew , Zhang Zipei , Li Xiyu , Zhang Wei , Cullion Kathleen , Kohane Daniel S. , Weldon Christopher B. 
Published: April 2023

AbstractDelivery of hydrophilic small molecule therapeutics by traditional drug delivery systems is challenging. Herein, we have used the specific interaction between DNA aptamers and drugs to create simple and effective drug depot systems. The specific binding of a phosphorothioate-modified aptamer to drugs formed non-covalent aptamer/drug complexes, which created a sustained release system. We demonstrated the effectiveness of this system with small hydrophilic molecules, the site 1 sodium channel blockers tetrodotoxin and saxitoxin. The aptamer-based delivery system greatly prolonged the duration of local anesthesia and reduced systemic toxicity. The beneficial effects of the aptamers were restricted to the compounds they were specific to. These studies establish aptamers as a class of highly specific, modifiable drug delivery systems, and demonstrate potential usefulness in the management of postoperative pain.