bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alteration in oxygen consumption of fresh water fish Puntius stigma exposed to sublethal concentrations of insecticide Phytofos
Authors: Lonkar A.N. 
Published: January 2023

Now a days large number of new insecticide formulations are used to protect the crops from various insects. Water pollution caused by insecticide is a serious problem it affects the aquatic animals adversely. Static bioassay experiments were conducted to find out 96 hr LC 50 value for fish Puntius stigma. For finding out respiratory response, the fishes of average length 3.7 Cm. were exposed to 0.4 mg/l (1/10 96 hr LC 50) and 0.8 mg/l (1/5 96 hr LC 50) concentrations of Phytofos. The respiratory response in terms of oxygen consumption was recorded at 24,48,72 and 96 hours.At the end of first 24 hours there is an increase in oxygen consumption is noted at 0.4 mg/l and 0.8 mg/l concentrations. At 48 hours exposure there is decrease in oxygen consumption at concentration 0.4 mg/l and at concentration 0.8 mg/l. At the end of 72 hours, there is a fall in oxygen consumption rate at both the concentration is recorded. At the end of 96 hours exposure, a reduction in oxygen consumption rate at concentration 0.4 mg/I and a just a little more fall in oxygen consumption at concentration 0.8 mg/l is noted. On transfer to toxicant free water (after 96 hours to 120 hours exposure) fishes showed recovery. Oxygen consumption in fishes are discussed with respect to time of exposure and sub lethal concentrations of insecticide Phytofos.
Sikap Dan Partisipasi Masyarakat Lokal Dalam Pengembangan Desa Undisan Sebagai Desa Wisata Di Kecamatan Tembuku, Kabupaten Bangli, Propinsi Bali
Authors: Paramita Ratri , Sukarno Teguh Hadi , Susianti Hartanti Woro 
Published: January 2023

Desa Undisan menawarkan banyak keunikan selain pemandangan alamnya yang indah, juga keunikan rumah adat asli Bali sesuai dengan Asta Kosala Kosali yang terkenal. Terdapat juga situs yang dipercaya sebagai peninggalan zaman lampau yang sering dijadikan sarana olah spiritual umat hindu ataupun orang orang yanag mendambakan ketenangan bathin. Air terjun Tangkup yng berlokasi di kawassan subak Selat,

menawarkan nuansa yaang masih sangat alami dan udara yang segar menjadi daya tarik wisata lainnya. Dipercaya bahwa air dari air terjun Tangkup ini berkhasiat untuk menyembuhkan bebearapa penyakit karena air yang tercurah muncul dari tebing batu yang menyerupai Sosok Orang yang sedang duduk bersemadi. Potensi lain yang dimiliki Desa Wisata Undisan adalah adanya tempat kerajinan bunga spon dan bunga imitasi dari emas dan perak yang dapat dissaksikan dan dikunjungi oleh wisatawan manca negara. Perhiasan tesebut banyak digunakan untuk perlengkapan upacara adat di Bali dan kebanyakan dikirim ke kota Denpasar. Selain itu, di sekeliling Desa Wisata Undisan terdapat hamparan sawah yang luas dan indah dipadu dengan Alam pegunungan, hutan dan sangat cocok untuk kegiatan wisata berbasis alam. Menyambut terbitnya PERBUP nomor 15 Tahun 2014 Kabupaten Bangli yang memasukkan Desa Undisan di Kecamatan Tembuku sebagai salah satu Desa Wisata, masyarakat Desa Undisan menginginkan Desa Wisata Undisan dapat berkembang menjadi Desa Wisata yang menarik bagi wisatawan untuk berkunjung dan berharap penetapan status Desa Wisata mampu meningkatkan taraf hidup ke arah yang lebih baik. Masyarakat Desa Wisata Undisan juga sudah membentuk Kelompok Sadar Wisata (POKDARWIS) dan telah disahkan oleh Pemerintah Kabupaten Bangli. Riset didesain buat mengidentifikasikan kemampuan Kabupaten Simalungun dalam mempraktikkan smart tourism yang ditinjau dari prasarana TIK. Riset ini memakai pendekatan riset deskriptif kualitatif dengan metode pengumpulan informasi tanya jawab, pemantauan serta riset pemilihan. Dari hasil riset diperoleh kalau prasarana TIK pariwisata Kabupaten Simalungun sedang kurang tersadar dalam mempraktikkan rancangan smart tourism. Kabupaten Simalungun terkini mengggunakan isyarat QR, alat sosial, serta sistem saran untuk turis dalam pengelompokan teknologi smart tourism
Familial Lamellar Ichthyosis in 6 Years Old and 2 Years Old Children: A Rare Case Report
Authors: Ellistasari Endra Yustin , Suci Widhiati  , Ervina Rosmarwati  
Published: January 2023

Background: Lamellar ichthyosis (LI) is a rare non-syndromic congenital ichthyosis and is autosomal recessive. LI patients are generally born with abnormalities of keratinization, then develop into lamellar scales and persist into adulthood. This study aimed to describe cases of lamellar ichthyosis and provide appropriate management to prevent worsening patient prognosis.
Case presentation: A 6-year-old girl and her younger brother, 2-year-old have been complaining of scaly skin all over their bodies since birth. Both patients were born with a history of being covered by a collodion membrane. On physical examination, thick and wide lamellar scales were seen with an erythematous base and palmoplantar hyperkeratosis. Ectropion of the eyelids, eclabium in the mouth area, and microtia in the ears were seen. The results of the dermoscopy examination showed brownish quadrilateral structures with white scales forming a lamellar pattern. Laboratory examination showed vitamin D insufficiency. Both patients were referred to the Pediatric Polyclinic regarding insufficiency and developmental complaints. Patients received therapy in the form of moisturizers, artificial eye drops, topical urea as a keratolytic, and oral vitamin D 2,000 IU per day. There was a clinical improvement after 3 months of treatment.
Conclusion: Lamellar ichthyosis is an autosomal recessive congenital ichthyosis with clinical manifestations limited to the skin. In a minority of cases, LI can be inherited in an autosomal dominant manner. Thorough management is necessary to prevent a poor prognosis in patients.
Quantitative determination of monoamine neurotransmitters in rat brain homogenates using HPLC-MS/MS
Authors: Popov N. S. , Gavrilenko D. A. , Balabanyan V. Yu. , Petrova M. B. , Donskov S. A. , Atadzhanov I. B. , Shatokhina N. A. 
Published: January 2023

Relevance. Evaluation of the effect of drugs on neurotransmitter processes is an important component of pharmacodynamic studies. The quantitative determination of monoamine neurotransmitters in the brain structures of laboratory animals is an urgent task of pharmacology and physiology.Purpose of the study. Development of a method for the quantitative determination of serotonin, dopamine, norepinephrine, histamine and epinephrine in rat brain homogenates using HPLC-MS/MS.Methods. The isolation of neurotransmitters from the brain of rats was carried out by homogenizing the biomaterial with acetonitrile and hydrochloric acid. The extraction was purified by liquid-liquid extraction with chloroform and isopropanol. Monoamines were detected using an AB Sciex QTrap 3200MD mass spectrometer, chromatography was performed using an Agilent Technologies 1260 Infinity II HPLC. Methanol and deionized water were used as eluent.Results. Sample preparation consisted of centrifugation of the resulting homogenate, drying of the supernatant in a stream of nitrogen, dissolution of the precipitate in the mobile phase, and purification of the solution using a mixture of chloroform and isopropanol. An Agilent InfinityLab Poroshell 120 EC-C18 4.6×100 mm, 2.7 μm analytical column was used to separate monoamine neurotransmitters. The total time of the chromatographic analysis was 12 minutes, the retention time of norepinephrine, epinephrine, dopamine, serotonin, histamine was 2.8; 3.2; 5.4; 7.9; and 2.2 minutes, respectively. The analytical range of the technique was 25.0–5000.0 ng/g for epinephrine, histamine, and dopamine; 5.0–5000.0 ng/g for serotonin and 50.0–5000.0 for norepinephrine. To test the technique, we analyzed monoamine neurotransmitters in the striatum of intact Wistar rats.Conclusion. The developed bioanalytical HPLC-MS/MS method for the quantitative determination of monoamine neurotransmitters in the rat brain fully complies with the validation requirements. The metrological characteristics of the technique make it possible to estimate the content of norepinephrine, epinephrine, dopamine, serotonin, and histamine in the brain structures of rats with high accuracy.
Empagliflozin and Decreased Risk of Nephrolithiasis: A Potential New Role for SGLT2 Inhibition?
Authors: Balasubramanian P. , Wanner C. , Ferreira J. P. , Ofstad A. P. , Elsaesser A. , Zinman B. , Inzucchi S. E. 
Published: January 2023

Diabetes mellitus is a risk factor for nephrolithiasis. A recent observational study found that in patients with type 2 diabetes (T2D), SGLT2 inhibitor use was associated with a 49% lower risk of nephrolithiasis compared with GLP-1 receptor agonists.
Aim: we examined the association between nephrolithiasis and the SGLT2 inhibitor empagliflozin, using existing data from randomized clinical trials.
Methods: we pooled data from 15 081 T2D patients randomized to empagliflozin (n = 10 177) or placebo (n = 4904) from 20 phase I-IV trials, including the large cardiovascular outcome trial, EMPA-REG OUTCOME. Incident urinary tract stone events were captured using a predefined collection of MedRA terms. A sensitivity analysis using a narrower definition was also performed. Incidence rate ratios (IRR) and 95% CIs were calculated using the relative risk estimate, stratified by study.
Results: the median exposures to study drug were 543 days (placebo) and 549 days (empagliflozin); 183 patients experienced an incident urolithiasis during follow-up (placebo, 79; empagliflozin, 104), yielding annual incidence rates of 1.01 vs 0.63 events/100 patient-years in the 2 respective groups. The IRR was 0.64 (95% CI, 0.48-0.86), in favor of empagliflozin. In the sensitivity analysis, the results were similar (IRR, 0.62 [95% CI, 0.45-0.85]).
Conclusion: compared with placebo, empagliflozin therapy was associated with an approximate 40% reduced risk of urinary tract stone events in T2D patients. The underlying mechanisms are unknown but may involve altered lithogenic profile of the urine. Dedicated randomized prospective clinical trials are warranted to confirm these initial observations in patients with and without T2D.
Anticoagulant therapy for pulmonary embolism in cancer patients
Authors: Tseluiko V. Y. , Shilo N. G. , Sukhova S. M. 
Published: January 2023

Venous thromboembolic complications most often occur in cancer patients, which is a big problem for the doctor in each specific case and for the health care system in general.
The article highlights the peculiarities of diagnosis, establishing the stage of the tumor process and risk factors for the occurrence of pulmonary embolism. Considerable attention is paid to the peculiarities of the selection of drugs and their dosage for the treatment of the specified cohort of patients.
Mechanical Energy Deposition in Cool Star Atmospheres: Resonant Coupling to Coronal Loops in M Dwarfs
Authors: Mullan D. J. 
Published: January 2023

Abstract
The efficiency of coronal heating ε(cor) in a star can be quantified by L
X/L
bol, i.e., the ratio of X-ray luminosity to bolometric luminosity. The efficiency of chromospheric heating in the same star ε(chr) is typically assumed to be proportional to L(Hα)/L
bol or L(Ca K)/L
bol where the lines Hα and Ca K are often the two strongest emission lines in the visible spectrum: the constant of proportionality (η = ε(chr)/[L(Hα)/L
bol] > 1) includes contributions from many other lines emitted by the chromosphere. In the case of the quiet Sun, it has been known for decades that, in the Sun, the efficiency of chromospheric heating is larger by a factor of ε(chr)/ε(cor) > 10 than the efficiency of coronal heating. Over the intervening years, data pertaining to ε(cor) and ε(chr) have been estimated for an increasingly large sample of main-sequence stars with spectral types later than the Sun. These data suggest that among M dwarfs, the efficiency ratio ε(chr)/ε(cor) may in some stars become smaller than in the solar case. The effect of this is such that the value of ε(cor) may become comparable to the value of ε(chr). Here, we seek to understand why coronal heating may be >10 times more efficient (relative to chromospheric heating) in certain M dwarfs than in the Sun. Using data on coronal loop properties in flaring stars, we examine the hypothesis that in M dwarfs, the enhanced efficiency of coronal heating may be related to resonant coupling between coronal loops and the source of mechanical energy in the convection zone.
Types of Transients in the Centers of Post-starburst and Quiescent Balmer-strong Galaxies
Authors: Arcavi Iair , Nyiha Irura , French K. Decker 
Published: January 2023

Abstract
Tidal disruption events (TDEs) have been found to show a preference for post-starburst (PS) and quiescent Balmer-strong (QBS) galaxies. This preference can be used to help find TDEs in transient surveys. But what other transients might “contaminate” such a search, and by how much? We examine all reported transients coincident with the centers of galaxies in the French & Zabludoff (2018) catalog of spectroscopically confirmed PS and QBS galaxies and photometrically identified PS and QBS galaxy candidates. We find that TDEs and Type Ia supernovae (SNe) are the only types of transients classified in the centers of these galaxies (aside from one active galactic nucleus flare), with Type Ia SNe being 8.3 ± 0.2 times more prevalent than TDEs (1σ confidence bounds). This factor is ∼2.7 times lower than in a control sample of quiescent galaxies. Narrowing the sample to spectroscopically confirmed QBS galaxies does not change these statistics much. In spectroscopically confirmed PS galaxies, however, TDEs are the ones that outnumber Type Ia SNe 2 ± 0.6 to 1. Unfortunately, there are few such galaxies in the catalog. By classifying transients from the entire catalog, three times more TDEs are expected to be found, but with a ∼16 times larger Type Ia SN contamination. We use the public ZTF photometric archive to search for possibly missed TDEs in the French & Zabludoff (2018) galaxies. We find three unclassified clear transients—none of which are likely missed TDEs based on their light-curve colors.
Deep X-Ray and Radio Observations of the First Outburst of the Young Magnetar Swift J1818.0−1607
Authors: Ibrahim A. Y. , Borghese A. , Rea N. , Zelati F. Coti , Parent E. , Russell T. D. , Ascenzi S. , Sathyaprakash R. , Götz D. , Mereghetti S. , Topinka M. , Rigoselli M. , Savchenko V. , Campana S. , Israel G. L. , Tiengo A. , Perna R. , Turolla R. , Zane S. , Esposito P. , Castillo G. A. Rodríguez , Graber V. , Possenti A. , Dehman C. , Ronchi M. , Loru S. 
Published: January 2023

Abstract
Swift J1818.0−1607 is a radio-loud magnetar with a spin period of 1.36 s and a dipolar magnetic field strength of B ∼ 3 × 1014 G, which is very young compared to the Galactic pulsar population. We report here on the long-term X-ray monitoring campaign of this young magnetar using XMM-Newton, NuSTAR, and Swift from the activation of its first outburst in 2020 March until 2021 October, as well as INTEGRAL upper limits on its hard X-ray emission. The 1–10 keV magnetar spectrum is well modeled by an absorbed blackbody with a temperature of kT
BB ∼ 1.1 keV and apparent reduction in the radius of the emitting region from ∼0.6 to ∼0.2 km. We also confirm the bright diffuse X-ray emission around the source extending between ∼50″ and ∼110″. A timing analysis revealed large torque variability, with an average spin-down rate

ν

̇

∼

−2.3 × 10−11 Hz2 that appears to decrease in magnitude over time. We also observed Swift J1818.0−1607 with the Karl G. Jansky Very Large Array on 2021 March 22. We detected the radio counterpart to Swift J1818 measuring a flux density of S

v
= 4.38 ± 0.05 mJy at 3 GHz and a half-ringlike structure of bright diffuse radio emission located at ∼90″ to the west of the magnetar. We tentatively suggest that the diffuse X-ray emission is due to a dust-scattering halo and that the radio structure may be associated with the supernova remnant of this young pulsar, based on its morphology.
Cool, Luminous, and Highly Variable Stars in the Magellanic Clouds. II. Spectroscopic and Environmental Analysis of Thorne–Żytkow Object and Super-AGB Star Candidates
Authors: O‘Grady Anna J. G. , Drout Maria R. , Gaensler B. M. , Kochanek C. S. , Neugent Kathryn F. , Doherty Carolyn L. , Speagle 沈 Joshua S. 佳士 , Shappee B. J. , Rauch Michael , Götberg Ylva , Ludwig Bethany , Thompson Todd A. 
Published: January 2023

Abstract
In previous work, we identified a population of 38 cool and luminous variable stars in the Magellanic Clouds and examined 11 in detail in order to classify them as either Thorne–Żytkow objects (TŻOs; red supergiants with a neutron star cores) or super-asymptotic giant branch (sAGB) stars (the most massive stars that will not undergo core collapse). This population includes HV 2112, a peculiar star previously considered in other works to be either a TŻO or high-mass asymptotic giant branch (AGB) star. Here we continue this investigation, using the kinematic and radio environments and local star formation history of these stars to place constraints on the age of the progenitor systems and the presence of past supernovae. These stars are not associated with regions of recent star formation, and we find no evidence of past supernovae at their locations. Finally, we also assess the presence of heavy elements and lithium in their spectra compared to red supergiants. We find strong absorption in Li and s-process elements compared to RSGs in most of the sample, consistent with sAGB nucleosynthesis, while HV 2112 shows additional strong lines associated with TŻO nucleosynthesis. Coupled with our previous mass estimates, the results are consistent with the stars being massive (∼4–6.5 M
⊙) or sAGB (∼6.5–12 M
⊙) stars in the thermally pulsing phase, providing crucial observations of the transition between low- and high-mass stellar populations. HV 2112 is more ambiguous; it could either be a maximally massive sAGB star, or a TŻO if the minimum mass for stability extends down to ≲13 M
⊙.
Electrostatic Plasma Wave Excitations at the Interplanetary Shocks
Authors: Singh Manpreet , Fraschetti Federico , Giacalone Joe 
Published: January 2023

Abstract
Over the last few decades, different types of plasma waves (e.g., the ion acoustic waves (IAWs), electrostatic solitary waves, upper/lower hybrid waves, and Langmuir waves) have been observed in the upstream, downstream, and ramp regions of the collisionless interplanetary (IP) shocks. These waves may appear as short-duration (only a few milliseconds at 1 au) electric field signatures in the in-situ measurements, with typical frequencies of ∼1–10 kHz. A number of IAW features at the IP shocks seem to be unexplained by kinetic models and require a new modeling effort. Thus, this paper is dedicated to bridging this gap in understanding. In this paper, we model the linear IAWs inside the shock ramp by devising a novel linearization method for the two-fluid magnetohydrodynamic equations with spatially dependent shock parameters. It is found that, for parallel propagating waves, the linear dispersion relation leads to a finite growth rate, which is dependent on the shock density compression ratio, as Wind data suggest. Further analysis reveals that the wave frequency grows towards the downstream region within the shock ramp, and the wave growth rate is independent of the electron-to-ion temperature ratio, as Magnetospheric Multiscale (MMS) in-situ measurements suggest, and is uniform within the shock ramp. Thus, this study helps in understanding the characteristics of the IAWs at the collisionless IP shocks.
The Late Afterglow of GW170817/GRB 170817A: A Large Viewing Angle and the Shift of the Hubble Constant to a Value More Consistent with the Local Measurements
Authors: Wang Yi-Ying , Tang Shao-Peng , Jin Zhi-Ping , Fan Yi-Zhong 
Published: January 2023

Abstract
The multimessenger data of neutron star merger events are promising for constraining the Hubble constant. So far, GW170817 is still the unique gravitational wave event with multiwavelength electromagnetic counterparts. In particular, its radio and X-ray emission have been measured in the past ∼3–5 yr. In this work, we fit the long-lasting X-ray, optical, and radio afterglow light curves of GW170817/GRB 170817A, including the forward shock radiation from both the decelerating relativistic gamma-ray burst outflow and the subrelativistic kilonova outflow (though whether the second component contributes significantly is still uncertain), and find out a relatively large viewing angle (∼0.5 rad). Such a viewing angle has been taken as a prior in the gravitational wave data analysis, and the degeneracy between the viewing angle and the luminosity distance is broken. Finally, we have a Hubble constant

H

0

=

72.57

−
4.17

+
4.09

km

s

−
1

Mpc

−
1

, which is more consistent with that obtained by other local measurements. If rather similar values are inferred from multimessenger data of future neutron star merger events, it will provide critical support to the existence of the Hubble tension.
A Fresh Look at AGB Stars in Galactic Open Clusters with Gaia: Impact on Stellar Models and the Initial–Final Mass Relation
Authors: Marigo Paola , Bossini Diego , Trabucchi Michele , Addari Francesco , Girardi Léo , Cummings Jeffrey D. , Pastorelli Giada , Dal Tio Piero , Costa Guglielmo , Bressan Alessandro 
Published: January 2023

Abstract
Benefiting from the Gaia second and early third releases of photometric and astrometric data, we examine the population of asymptotic giant branch (AGB) stars that appear in the fields of intermediate-age and young open star clusters. We identify 49 AGB star candidates, brighter than the tip of the red giant branch, with a good to high cluster membership probability. Among them, we find 19 TP-AGB stars with known spectral type: 4 M stars, 3 MS/S stars, and 12 C stars. By combining observations, stellar models, and radiative transfer calculations that include the effect of circumstellar dust, we characterize each star in terms of initial mass, luminosity, mass-loss rate, core mass, period, and mode of pulsation. The information collected helps us shed light on the TP-AGB evolution at solar-like metallicity, placing constraints on the third dredge-up process, the initial masses of carbon stars, stellar winds, and the initial–final mass relation (IFMR). In particular, we find that two bright carbon stars, MSB 75 and BM IV 90, members of the clusters NGC 7789 and NGC 2660 (with similar ages of ≃ 1.2–1.6 Gyr and initial masses 2.1 ≳ M

i
/M
⊙ ≳ 1.9), have unusually high core masses, M

c
≈ 0.67–0.7 M
⊙. These results support the findings of a recent work (Marigo et al. 2020) that identified a kink in the IFMR, which interrupts its monotonic trend just at the same initial masses. Finally, we investigate two competing scenarios to explain the M

c
data: the role of stellar winds in single-star evolution, and binary interactions through the blue straggler channel.
Le chemin vers l’insertion des jeunes : être acteur de son parcours grâce à l’EPIDE
Authors: Gerard-Chalet Florence 
Published: January 2023

L’Établissement Pour l’Insertion Dans l’Emploi des jeunes (EPIDE) est né en 2005 de la volonté de permettre aux jeunes de 17 à 25 ans, avec peu ou pas de diplômes, de retrouver un chemin vers l’emploi ainsi qu’une dynamique sociale. La force de l’EPIDE est de proposer un accompagnement complet aux jeunes cumulant des facteurs de vulnérabilités, notamment ceux issus de QPV (quartiers prioritaires de la politique de la ville).
Freud à la recherche de l’inconscient : le corps étranger
Authors: Kamieniak Jean-Pierre 
Published: January 2023

Bien que le terme « inconscient » soit fort répandu et même banal à l’époque du jeune Freud, le neurologue se montrera réservé quant à son usage, optant pour des métaphores médicales comme le « corps étranger » ou l’« infiltrat » – lesquelles se montreront fécondes, lui permettant d’élaborer ce qui deviendra le concept spécifique de la psychanalyse : « l’Inconscient », faisant de lui un fondateur et un conquistador. Ce sont donc les prémices de ce savoir nouveau qui se voient évoquées ici.