bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the inhibitory effect of two local plants on the emergence of four weeds and identification of their secondary metabolites: Case of Parkia biglobosa (Jacq.) R.Br.ex G.Don. and Tephrosia purpurea (L.) Pers.
Authors: Sourabié Soumaïla , Sanou Yacouba , Zerbo Patrice 
Published: January 2023

In Burkina Faso, Senna occidentalis, Ipomoea eriocarpa, Pupalia lappacea and Triumfetta cordifolia are frequent weeds in the maize crop. This work evaluated the inhibitory effect of Parkia biglobosa pods and Tephrosia purpurea leaves and identifies their chemical compounds. Biological and chemical approaches were used to identify the weeds. The inhibitory effect of powders was evaluated on weed germination and growth. Experimental results showed that powders reduced both germination (p<0.001) and growth (p<0.016). Parkia biglobosa pods were rich in total flavonoids (544.2±1.4 µg mg-1) and condensed tannins (182.3±1.5 µg mg-1) than Tephrosia purpurea leaves which contained small amounts of total flavonoids (6.7±1.7 µg mg-1) and condensed tannins (5.7±1.2 µg mg-1). Parkia biglobosa pods could be used in the biological control of weeds.
Int. J. Agril. Res. Innov. Tech. 12(2): 74-81, December 2022
Tinjauan Histori pada Gaya Visual Iklan Cetak Coca-Cola
Authors: Prameswari Nadia Sigi 
Published: January 2023

Zeitgeis (jiwa zaman) memberikan pengaruh yang besar terhadap karakteristik hasil karya seni baik berupa lukisan, patung, relief-relief, ilustrasi, tulisan hingga berkembang menjadi iklan. Iklan merupakan salah satu karya seni yang muncul pada abad-17. Pada tahun 1880-an, beberapa produsen atau perusahaan mengadaptasi teknik-teknik yang penampilan iklan pada poster. Berbagai produsen makanan, minuman, obat dan peralatan mandi mulai memperkenalkan produknya melalui iklan poster. Pada tahun 1886 berdirilah The Coca-Cola Company di Amerika. Tahun 1906, William D'Arcy bergabung sebagai Creative Team yang merencanakan konsep iklan Coke dan memiliki pandangan bahwa "iklan Coca-Cola harus membuat adegan yang menarik orang-orang dalam dan membuat mereka bagian dari selingan menyenangkan dari kehidupan sehari-hari". Kajian ini merupakan tinjauan historis pengaruh gaya pada zaman Antiquity, Mediaeval, Renaissance, dan Baroque terhadap perkembangan gaya visual iklan cetak (print ad) Coca-Cola. Zeitgeis memberikan transisi terhadap perkembangan gaya visual iklan cetak Coca-Cola di setiap periode zaman.
PENGARUH KECERDASAN VISUAL SPASIAL DAN SELF CONCEPT TERHADAP KEMAMPUAN BERPIKIR KREATIF
Authors: Rahmawati Sri Desi , Mulyatna Fauzi , Gusniwati Mira 
Published: January 2023

This study aims to determine the effect of visual-spatial intelligence and self-concept on creative thinking skills. This research was conducted at Yapermas Junior High School and Taman Siswa Junior High School with a sample of 46 students in class VIII for the 2021/2022 academic year. The research method used is a correlational survey method. The instruments used are description tests (visual spatial intelligence and creative thinking skills) and questionnaires (self concept), all instruments have been validated. Before testing the hypothesis, the data requirements were tested, including: normality test with chi square test, all data were normally distributed, linearity test obtained all data with a linear pattern, and multicollinearity test obtained all data between variables X1 and X2, there was no multicollinearity. Then the hypothesis test is carried out to get the equation persamaan Y=12,58 +0,22 X1+0,75X2 and with a level of 5% it is obtained Fcount (6,99) > Ftable (3,21 ) then H0 is rejected. The results of the study concluded that 1) there was an effect of spatial visual intelligence and self-concept on the ability to think creatively, 2) there was an effect of visual-spatial intelligence on the ability to think creatively, and 3) there was an influence of self-concept on the ability to think creatively.
Невідомі карти та плани Ольвії та її околиць XIX ст.
Authors: Sаpоzhnykov Igor , Kuzmishchev Olexandr 
Published: January 2023

Мета статті полягає у введенні до наукового обігу та аналізу досі невідомих картографічних джерел, які зберігаються у різних музейних та архівних установах.
Наукова новизна пов’язана з тим, що розглянуті чотири плани і карти 1821, 1851, 1863 рр., що стосуються Ольвії та її околиць, що досі ніколи не попадали до наукового вжитку дослідників.
Наведено невідомі факти існування села Ольвія (Широке); два фрагменти аркуша «військової зйомки» Херсонської губернії 1851 р. (масштаб 1 : 42 000) з урочищем Сто Могил і ділянкою на північ від с. Парутине. Вперше розглянуто аркуш карти 1851 р. та план А.П. Чиркова 1863 р., на яких зображені Велике та Мале Аджигольські містечка (нині поселення Дніпровське ІІ), вперше описані академіком Е.Е. Келлером.
Висновки. У рамках порівняльного аналізу планів було встановлено локалізацію кургану, в якому була знайдена золота маска (1842 р.). Також була локалізована на планах курганна група біля балки Широкої, які булі розкопані у 1844 і 1853 рр. Наводиться інформація про кам’яні склепи, відомі у трьох з них.
У ході проведеного дослідження вдалося не тільки порівняти плани між собою, але й локалізувати раніше невідоме місцезнаходження «археологічного будинку», співвіднести місцезнаходження курганів, розкопаних у 1842, 1844 і 1853 рр. а також розібратися у заплутаній бібліографії стосовно місцезнаходження Аджигольського містечка.
Професор Львівського університету Ришард Ґаншинець
Authors: Petrechko Oleh , Тsymbal Tetiana 
Published: January 2023

Мета статті: на основі аналізу історичних джерел розглянути львівський період життя професора Ришарда Ґаншинця (1888-1958).
Наукова новизна: введено до наукового обігу низку архівних документів, що дозволило з’ясувати умови в яких відбувалася науково-педагогічна діяльність професора Ґаншинця у Львівському університеті.
Висновки. Професор Ришард Ґаншинець вніс великий вклад у справу становлення сучасної школи класичної філології у Львові. Львівський період його життя склав чверть століття і був важливим етапом його науково-педагогічної діяльності. Окрім роботи в університеті він виконував ще різного роду громадські обов’язки та редагував низку наукових журналів. Коло його наукових зацікавлень було досить широким, але передовсім його цікавили різні аспекти розвитку стародавніх релігій, особливо давньогрецької релігії та магії.
Друга світова війна завадила реалізації багатьох наукових планів вченого. У важких реаліях воєнного часу йому довелося працювати не за фахом, щоб прогодувати свою сім’ю, яка з наближенням лінії фронту виїхала у більш безпечне місце. Звільнення Львова від німецької окупації дало надію на налагодження мирного життя, відновлення наукової та педагогічної діяльності у Львівському університеті.
Однак, як і багатьом іншим представникам польської та української інтелігенції, професору Ґаншинцю довелося пройти через ув’язнення, боротися за повернення свого помешкання та речей. Серед іншого було втрачено щоденник вченого, який йому довелося власноруч знищити під час обшуку. Вчений довгий час не хотів виїжджати зі Львова у Польщу, однак прийняв таке рішення, коли стало очевидним, що надій на збереження польського Львова немає, а виїзд до Польщі є єдиною можливістю об’єднатися з сім’єю. Очевидно, що це важке рішення було виправдане в тих умовах і дозволило Ришарду Ґаншинцю продовжити плідну наукову та педагогічну діяльність.
Transformation of the Traditional Religiosity of the Ukrainian Peasantry (1920s – 1930s): Conceptualization of Research Problem
Authors: Kyrydon Alla , Kosiak Svitlana 
Published: January 2023

The purpose of the research paper is to highlight the set of circumstances and factors that caused the transformation of the peasantry traditional religiosity and to emphasize the interdependence of the processes in the event-contextual and mental-conscious spheres/dimensions.
Scientific novelty: Despite the rather thorough scientific analysis of the issue, the dominance of the positivist approach is observed in historiography; therefore, the conceptualization of the problem makes it possible to understand the non-fragmentary factual multiplicity of certain plots, which evinced in one way or another the transformations of religiosity in the social and cultural space of the 1920s – 1930s, but it allows to clarify and generalize the reasons, nature, dynamics, and essential characteristics of the processes related to the transformation of religiosity under the new social and cultural conditions of the communist-atheist power.
Conclusions. There is a certain dependency between the architectonics of human existence and the worldview benchmarks of a certain era. Therefore, not only anti-religious and anti-church propaganda (as a means of ideological influence), but also the socio-economic and political development of society (industrialization, collectivization, cultural revolution, renewal of everyday life, etc.) destroyed the former stable world of customs and rituals. Therefore, it is obviously worth talking not about the transformation of religiosity, but about complex transformations.
The nature of the religiosity transformational processes depended on many factors. In the context of the eroding of old church doctrines, the revision of fixed moral and ethical norms, the onset of atheism, in the eyes of Christians, the stable world was degrading, losing sanctified traditions and moral standards. Religious integrity and the durability of religious culture were lost. In search of compensation for the emerging worldview uncertainty, anxiety, dissatisfaction, etc., the individual looked for new benchmarks, values, ideals, and ways of organizing life in society through the transformation of stable forms and ways of life. In the confrontation of two worldview cultural models, society, having undergone complex transformations, slowly adapted to the conditions established by the communist regime and its worldview instructions.
Orthodoxy of Ukraine During the Occupation, 1939-1944: Confessional Transformations and Political Contexts
Authors: Lysenko Oleksandr , Mykhailutsa Mykola 
Published: January 2023

The purpose of the research paper is to analyze the influence of the social and political conditions on changes in confessional life in the occupied Ukrainian lands during World War II.
The scientific novelty: it is claimed that it was social and political conditions that caused drastic changes in the confessional map of Ukraine in 1939-1945. The determinant factor of the occupation policy – the destruction of the established confessional configuration that traditionally existed on Ukrainian lands in the USSR, Poland and Romania – has been proven. Autocephalous tendencies in Orthodox life in the General Governorate, Reichskommissariat ‘Ukraine’ and ‘Transnistria’ were studied. The personal visions of the leading Orthodox bishops regarding the institutional status of the Orthodox Church in Ukraine are reflected. The specific approaches of the German and Romanian administrations to the organization of church life are highlighted.
Conclusions: it is proved that despite the attempt to create a single Orthodox Church in the territory occupied by the Wehrmacht, this did not happen due to the position of the German leadership and different views of the hierarchs of the Orthodox churches. It has been proven that all institutional changes of the occupiers grossly violated the existing traditions and canonical norms, which deprived the Church of its autonomy. It was determined that multiconfessionalism and the lack of autocephalous status of Ukrainian Orthodoxy complicated the process of forming a single Orthodox Church of Ukraine. The influence of the Moscow Patriarchate, as well as the opposition of Berlin, made this process impossible during the war.
It is noted that the Romanian administration in the occupied south-western lands of Ukraine (‘Transnistria’), with the support of the Romanian Orthodox Mission, contributed to the revival of Christianity, relied on the pre-revolutionary church organization, clerics and monarchism. The Ukrainian-phobic attitudes of the majority of Romanian bishops and the occupation authorities which led to the fight against the sprouts of Ukrainian autocephaly are shown. It has been proven that the rebuilt churches, the restoration of services in them, the involvement of hundreds of clerics, Christian charity and charity, raising children in the spirit of piety, etc., contributed to the revival of ancient Christian traditions and, at the same time, were a tool for the affirmation of the occupation regime.
Curtailing crime dynamics: A mathematical approach
Authors: Kwofie Theophilus , Dogbatsey Matthias , Moore Stephen E. 
Published: January 2023

IntroductionCrime and criminal activities have huge influences on society and societal development. The social makeup of the society has a significant impact on the propagation of crime within a population. It is a well-known reality that crime spreads across society like an infectious disease, despite the fact that there are many elements that might affect this dynamic. So, understanding crime and the factors influencing its spread are essential in formulating policies to reduce the prevalence and impacts of crime.MethodsWe formulate a deterministic mathematical model using a system of nonlinear ordinary differential equations incorporating education programs as tools to assess the population-level impact on the spread of crime. The model has a global asymptotically stable crime-free equilibrium whenever a certain criminological threshold, known as the effective reproduction number RE, is less than unity.Results and discussionThe model is fitted with prison data reported from July 2021 to June 2022 by the State of Illinois in The United States. The simulations are carried out to assess the population-level impact of the widespread use of the intervention programs and the compliance rate in the State of Illinois. We hypothetically fixed the efficacy of the intervention programs at 25% while varying the compliance rate (by the general public). With no compliance, a high level of active criminal population was recorded. As the compliance rates were significantly improved, the active population level decreased. The global sensitivity analysis is performed primarily to determine the parameters with the most effect on the spread of crime in the State of Illinois. The results demonstrate that the effective community contact rate, βc, for the criminally active individuals is the main driver of crime in the State of Illinois.
Evaluation of probe-based ultra-sensitive detection of miRNA using a single-molecule fluorescence imaging method: miR-126 used as the model
Authors: Liu Longkai , Wang Xiaoning , Li Yan , Liu Jianwei 
Published: January 2023

This study proposed a new detection method of miRNA based on single-molecule fluorescence imaging, a method that has been successfully developed to measure the light signal of individual molecules labeled with proper fluorophores. We designed probes 1 and 2 to be labeled with Cy5 dye and BHQ2 quencher at the 3′terminals, respectively. Probe 1 consisted of two parts, the longer part complementary to miR-126 and the shorter part complementary to probe 2. After hybridization, miR-126 bound to probe 1 by replacing probe 2 and assembled into a double-stranded DNA with probe 1. The abundance of miR-126 was quantified by detecting image spots of Cy5 dye molecules from probe 1/miR-126 complexes. MiR-126 single-molecule imaging method showed high specificity and sensitivity for miR-126 with a detection limit of 50 fM. This method has good selectivity for miR-126 detection with 2.1-fold, 8.8-fold, and 26.9–41.3-fold higher than those of single-base mismatched miR-126, three-base mismatched miR-126 and non-complementary miRNAs (miR-221, miR-16, miR-143 and miR-141). The method to detect miR-126 was validated in breast cancer cell lines. Our single-molecule miRNA imaging showed high specificity and sensitivity for miRNAs. By changing the base pair sequence of the designed probes, our method would be able to detect different miRNAs.
Carotid atherosclerosis in people of European, South Asian and African Caribbean ethnicity in the Southall and Brent revisited study (SABRE)
Authors: Anbar Rayan , Chaturvedi Nish , Eastwood Sophie V. , Tillin Therese , Hughes Alun D. 
Published: January 2023

BackgroundAtherosclerotic cardiovascular disease (ASCVD) risk differs by ethnicity. In comparison with Europeans (EA) South Asian (SA) people in UK experience higher risk of coronary heart disease (CHD) and stroke, while African Caribbean people have a lower risk of CHD but a higher risk of stroke.AimTo compare carotid atherosclerosis in EA, SA, and AC participants in the Southall and Brent Revisited (SABRE) study and establish if any differences were explained by ASCVD risk factors.MethodsCardiovascular risk factors were measured, and carotid ultrasound was performed in 985 individuals (438 EA, 325 SA, 228 AC). Carotid artery plaques and intima-media thickness (cIMT) were measured. Associations of carotid atherosclerosis with ethnicity were investigated using generalised linear models (GLMs), with and without adjustment for non-modifiable (age, sex) and modifiable risk factors (education, diabetes, hypertension, total cholesterol, HDL-C, alcohol consumption, current smoking).ResultsPrevalence of any plaque was similar in EA and SA, but lower in AC (16, 16, and 6%, respectively; p &lt; 0.001). In those with plaque, total plaque area, numbers of plaques, plaque class, or greyscale median did not differ by ethnicity; adjustment for risk factors had minimal effects. cIMT was higher in AC than the other ethnic groups after adjustment for age and sex, adjustment for risk factors attenuated this difference.ConclusionPrevalence of carotid artery atherosclerotic plaques varies by ethnicity, independent of risk factors. Lower plaque prevalence in in AC is consistent with their lower risk of CHD but not their higher risk of stroke. Higher cIMT in AC may be explained by risk factors. The similarity of plaque burden in SA and EA despite established differences in ASCVD risk casts some doubt on the utility of carotid ultrasound as a means of assessing risk across these ethnic groups.
Sex differences in contributors to coronary microvascular dysfunction
Authors: Kwan Alan C. , Wei Janet , Ouyang David , Ebinger Joseph E. , Merz C. Noel Bairey , Berman Daniel , Cheng Susan 
Published: January 2023

BackgroundCoronary microvascular dysfunction (CMD) has differences in prevalence and presentation between women and men; however, we have limited understanding about underlying contributors to sex differences in CMD. Myocardial perfusion reserve index (MPRI), as semi-quantitative measure of myocardial perfusion derived from cardiac magnetic resonance (CMR) imaging has been validated as a measure of CMD. We sought to understand the sex differences in the relations between the MPRI and traditional measures of cardiovascular disease by CMR.MethodsA retrospective analysis of a single-center cohort of patients receiving clinical stress CMR from 2015 to 2022 was performed. Patients with calculated MPRI and no visible perfusion defects consistent with obstructive epicardial coronary disease were included. We compared associations between MPRI versus traditional cardiovascular risk factors and markers of cardiac structure/function in sex-stratified populations using univariable and multivariable regression models.ResultsA total of 229 patients [193 female, 36 male, median age 57 (47–67) years] were included in the analysis. In the female population, no traditional cardiovascular risk factors were associated with MPRI, whereas in the male population, diabetes (β: −0.80, p = 0.03) and hyperlipidemia (β: −0.76, p = 0.006) were both associated with reduced MPRI in multivariable models. Multivariable models revealed significant associations between reduced MPRI and increased ascending aortic diameter (β: −0.42, p = 0.005) and T1 times (β: −0.0056, p = 0.03) in the male population, and increased T1 times (β: −0.0037, p = 0.006) and LVMI (β: −0.022, p = 0.0003) in the female population.ConclusionThe findings suggest different underlying pathophysiology of CMD in men versus women, with lower MPRI in male patients fitting a more “traditional” atherosclerotic profile.
Observation of the effectiveness of clinical indicators of cardiac shock wave therapy in patients with ischemic heart disease: A systematic review and meta-analysis
Authors: Wu Xinze , Gu Minghong , Ma Yixuan , Song Peiyu , Fang Chenghu 
Published: January 2023

ObjectiveIschemic heart disease (IHD) has a high prevalence and mortality rate, imposing a heavy burden on patients and society, and there is still a need to optimize treatment options for IHD patients. Cardiac shock wave therapy (CSWT) is gaining popularity as a new treatment for IHD patients. The objective of this meta-analysis is to reassess the effects of CSWT on IHD patients in light of the limited number of clinical studies included in previously published reviews, inconsistent methodological quality, and unclear outcomes.MethodsFrom database creation until September 1, 2022, 4 English databases and 3 Chinese databases were rigorously searched for any current controlled trials of CSWT for IHD. The Cochrane Risk of Bias Assessment Tool was used for methodological quality assessment. Review Manager v.5.4 software was used for meta-analysis.ResultsNineteen published controlled trials totaling 1,254 subjects were included. Results showed that CSWT could enhance left ventricular function and myocardial viability, improve cardiac function and alleviate angina pectoris symptoms. The effects of CSWT and control groups on SAQ scores and exercise time were not statistically significant.ConclusionAccording to this systematic review and meta-analysis, CSWT may be beneficial for a number of IHD clinical indications. To verify these findings, more RCT studies with bigger sample numbers and higher methodological standards are required in the future.
Role of mitochondrial metabolism in immune checkpoint inhibitors-related myocarditis
Authors: Zhang Xin , Gan Yi , Zhu Haoshuai , Liu Zhihao , Yao Xiaojing , Cheng Chao , Liu Zhenguo , Su Chunhua , Zou Jianyong 
Published: January 2023

BackgroundImmune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great significance to understand the pathophysiological mechanism of immune checkpoint inhibitor-related myocarditis.MethodsTissue samples from three patients with immune checkpoint inhibitor-related myocarditis and three control tissue samples were collected for protein analysis. Differentially expressed proteins were screened out using quantitative proteomics technology based on TMT markers. Protein–protein interaction (PPI) and Gene Ontology (GO) functional enrichment analyses of cross-factors were subsequently performed. Combined with the PD-L1 subcellular organelle- level protein interaction network, we searched for hub proteins involved in immune checkpoint inhibitor-related myocarditis and explored potential drug sensitivity and disease correlation.ResultsA total of 306 differentially expressed proteins were identified in immune checkpoint inhibitor-related myocarditis. Enrichment analysis showed that the differentially expressed proteins were closely related to mitochondrial metabolism. By analyzing mitochondria-related proteins and PD-L1-related proteins, we found four hub proteins, mammalian target of rapamycin (mTOR), Glycogen synthase kinase 3β (GSK3β), Protein tyrosine phosphatase non-receptor type 11 (PTPN11), and Mitofusin 2 (MFN2), indicating that they are closely related to immune checkpoint inhibitor-related myocarditis. Finally, we explored potential drugs for the treatment of immune checkpoint inhibitor-related myocarditis.ConclusionMitochondrial metabolism is involved in the process of immune checkpoint inhibitor-related myocarditis, and we identified four hub proteins, which may become new biomarkers for the early diagnosis and treatment of immune checkpoint inhibitor-related myocarditis.