bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refurbishing used GPS transmitters improves performance for subsequent deployments on greater sage‐grouse
Authors: Chelak Melissa S. , Kohl Michel T. , Small Justin R. , Smith Kurt T. , Pratt Aaron C. , Beck Jeffrey L. , Backen Codi R. , Brandon Flack M. , Wayment Hailey P. , Wood Jason A. , Howell Ryan , Strange Trevon D. , McDonald Lucian R. , Manlove Kezia R. , Frey Shandra N. , Larsen Randy T. , Maxfield Brian A. , Dahlgren David K. , Messmer Terry A. , Stoner David C. 
Published: January 2025

AbstractGlobal Positioning Systems (GPS) radio transmitters are increasingly used across taxa to monitor animal populations. However, GPS transmitters can be susceptible to malfunctions that may result in location errors or data loss causing potential inferential bias that can have important implications for monitored species. Research using GPS transmitters on greater sage‐grouse (Centrocercus urophasianus; sage‐grouse) has increased, but few sage‐grouse studies have evaluated GPS performance. Because sage‐grouse management has been subject to intense legal and political scrutiny with consequential economic implications, reliable data acquisition is central to informed decision‐making for the species. We evaluated differences in the performance of 2 commonly used solar‐powered GPS transmitters (Microwave Telemetry, Inc. [MTI], Columbia, MD, USA and GeoTrak, Inc., Apex, NC, USA) deployed on sage‐grouse throughout Wyoming from 2011 to 2017 and Utah from 2013 to 2019. Our investigation of GPS performance included daily fix inefficiency, the number of 1‐day fix gaps, and transmitter loss rate. We also evaluated transmitter functionality during the nesting period including daily nesting fix inefficiency, fix error distance mean and standard deviation (i.e., accuracy and precision), and mean fix error direction. New and refurbished MTI transmitters outperformed GeoTrak transmitters in daily fix inefficiency and day gaps during most seasons. Cumulatively redeployed MTI transmitters did not perform differently than GeoTrak transmitters. Transmitter loss, daily nesting fix inefficiency, and nest fix precision did not vary significantly between the 2 transmitters. GeoTrak performed better than MTI for nest fix accuracy across all latitudes (40–45° N). The mean error direction to the nest location ranged between 105° and 135° for GeoTrak and between 135° and 155° for MTI. We recommend refurbishing transmitters following deployment to retain higher fix efficiency than cumulatively redeploying transmitters.
Another Industrial Revolution? It’s All Evolution!
Authors: Kask Johan , Armstrong Ryan 
Published: January 2025

Abstract
This chapter questions the increasingly popular narrative of technological advancement as a series of abrupt “Industrial Revolutions,” favoring instead an understanding of technological change as an ongoing process of “Industrial Evolution.” We argue that the recent explosion in the use of the Fourth Industrial Revolution and related terms are indicative of its use as a buzzword. By examining the music recording industry’s transformation, the authors illustrate that perceived “revolutionary” shifts are better understood as cumulative, evolutionary processes, shaped by societal shifts and cumulative advancements in technology. The study advocates hence for a nuanced understanding of technological progress, emphasizing the interconnected and path-dependent nature of developments. It argues that the concept of distinct industrial revolutions generally oversimplifies the complex and continuous trajectory of technological and industrial evolution. The implications for research include a call for a shift in conceptual frameworks and research methodologies, emphasizing longitudinal studies and interdisciplinary approaches that acknowledge historical dependencies rather than suggesting questionable scenarios before and after. For practitioners, the notion of “Industrial Evolution” necessitates a deeper historical understanding of strategic decision-making. Policymakers are encouraged to adopt a visionary, long-term perspective to foster sustained and inclusive innovation. The chapter concludes with a call for further exploration through longitudinal case studies across various sectors and investigation into the pace of socio-technological evolution.
Creating Value by Combining AI and Other Open Technologies: Cloud Infrastructure as a Pivotal Asset
Authors: Legenvre Hervé , Autio Erkko , Hameri Ari-Pekka 
Published: January 2025

Abstract
This paper introduces the notion of “pivotal assets” to describe the role of cloud infrastructures as a central, shared resource that enables value creation across the digital landscape. Through our analysis, we explore how cloud infrastructures, with their broad array of complementary digital technologies, support, enhance, and help build new digital services. We describe how digital incumbents have facilitated the emergence of cloud infrastructures of supermodular complementarities—synergies that yield value greater than the sum of their parts—through the strategic release of open technologies. These technologies range from open-source software to pre-trained machine learning algorithms and open hardware designs, all available under permissive licensing terms. This strategy has created momentum within the cloud and AI/machine learning ecosystem resulting in generative outcomes through the exploitation of supermodular complementarities.
Digital redesign of the radiotherapy course for medical students with a blended learning approach
Authors: Knöchelmann Anne Caroline , Becker Jan-Niklas , Stiller Gerald , Steinmann Diana , Behrends Marianne 
Published: January 2025

Abstract

Purpose
Due to the need for high-quality teaching, we present a new blended learning concept combining digital modules, interactive seminars, and clinical experience. Furthermore, we evaluated its acceptance among students.

Methods
A new concept for teaching was applied to the radiotherapy module and made available via the Hannover Medical School (MHH) learning management system as part of a blended learning concept with educational films, multimedia learning modules, online seminars, and onsite practical training. The evaluation recorded assessments of the requirement profile, design, and opportunities for skills acquisition; evaluation of the seminar and internship; and questions on the overall assessment.

Results
The new concept was applied to four passes in the fourth academic year. A total of 152 students completed the radio-oncology learning module, which was evaluated by 46 students. Forty students considered the course duration to be appropriate for the material covered, and most students stated that their prior knowledge had been sufficient. The level of difficulty of the content was rated by the students as somewhat too high. The design of the digital course, the opportunity to acquire skills, the seminar course, and the practical course were mostly rated positively.

Conclusion
Through digital redesign, a teaching concept can be implemented that combines self-determined learning, professional exchange with doctors, and clinical practice experience. The concept can be transferred to other areas because it combines theoretical knowledge transfer with synchronous teaching and clinical experience. The results of the evaluation show that the students rated the new concept well.
Nobiletin reduces 5-FU-induced lung injury with antioxidative, anti-inflammatory and anti-apoptotic activities
Authors: Atila Uslu Gözde , Uslu Hamit , Çoban Taha Abdulkadir , Özkaraca Mustafa , Mendil Ali Sefa , Aygörmez Serpil 
Published: January 2025

Abstract
Like other chemotherapeutic agents, 5-fluorouracil (5-FU) targets cancerous cells, but it also causes many unwanted side effects on healthy tissues and cells. Based on the undesirable effects of 5-FU, the aim of this study was to determine how 5-FU affects lung tissue and whether nobiletin has any protective effect. The study consisted of negative control, Nobiletin, 5-FU and Nobiletin + 5-FU groups. Nobiletin and Nobiletin + 5-FU groups received 10 mg/kg Nobiletin i.g. for 7 days. On day 8, 100 mg/kg 5-FU was administered i.p. to 5-FU and Nobiletin + 5-FU groups. Biochemical and immunohistochemical analyses were performed on the lung tissues dissected at the end of the study. 5-FU caused growth retardation, disturbed the oxidant-antioxidant balance by increasing MDA levels and decreasing GSH levels, triggered cellular apoptosis by increasing Bax and caspase-3 levels and decreasing Bcl-2, also increased lung tissue inflammation and damage by increasing NFκB and IL-1β levels. However, it was determined that Nobiletin prevented the disruption of the oxidant-antioxidant balance, showed significant anti-apoptotic effects, especially by reducing Bax levels and partially modulating caspase-3 and Bcl-2 levels, and also exhibited anti-inflammatory effects by reducing NFκB and IL-1β levels and supported the normal development of animals. Our results showed that nobiletin pretreatment showed anti-inflammatory activity by inhibiting the NFκB pathway in 5-FU-induced lung injury, suppressed oxidative stress with its antioxidant activity and was effective in modulating cellular apoptosis with its anti-apoptotic activity. In conclusion, Nobiletin has been shown to have an important potential in reducing fluorouracil-induced tissue damage by acting through multiple pathways.

Graphical Abstract
A phase I study of MLN4924 and belinostat in relapsed/refractory acute myeloid leukemia or myelodysplastic syndrome
Authors: Maher Keri R. , Shafer Danielle , Schaar Dale , Bandyopadhyay Dipankar , Deng Xiaoyan , Wright John , Piekarz Richard , Rudek Michelle A. , Harvey R. Donald , Grant Steven 
Published: January 2025

Abstract

Purpose
Relapsed and/or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome continue to have a poor prognosis with limited treatment options despite advancements in rational combination and targeted therapies. Belinostat (an HDAC inhibitor) and Pevonedistat (a NEDD8 inhibitor) have each been independently studied in hematologic malignancies and have tolerable safety profiles with limited single-agent activity. Preclinical studies in AML cell lines and primary AML cells show the combination to be highly synergistic, particularly in high-risk phenotypes such as p53 mutant and FLT-3-ITD positive cells. Here, we present the safety, pharmacokinetics and pharmacodynamics of belinostat and pevonedistat in a dose escalation Phase I study in AML and High-Risk MDS.

Methods
Eighteen patients (16 with AML, 2 with MDS) were treated at 5 dose levels (belinostat 800–1000 mg/m2, pevonedistat 20–50 mg/m2). Safety and tolerability were assessed according to protocol defined dose limiting toxicities (DLTs). Correlative pharmacokinetic and pharmacodynamic analyses were performed.

Results
No dose limiting toxicities were noted. Most Grade 3 or 4 toxicities were hematologic in nature. The best response was stable disease in four patients, and complete remission in one patient who qualified as an exceptional responder. Pharmakokinetic studies revealed no association between drug exposure and best response. Pharmacodynamic RT-PCR studies demonstrated post-treatment increases in several proteins, including quantitative increases in the oxidative stress protein NQO1, ferroptosis protein SLC7A11, and GSR, linked to glutathione metabolism and oxidative stress, as did the anti-oxidants SRXN1 and TXNRD1.

Conclusions
Patterns of post-treatment changes in correlative pharmacodynamic parameters may suggest possible mechanistic changes in the DNA damage response, oxidative damage, and ferroptosis pathways. The combination of pevonedistat plus belinosat is safe in an adult relapsed and/or refractory AML/High-Risk MDS population with modest but notable activity in this heavily treated, high risk population. Our findings also raise the possibility that certain extremely poor prognosis AML patients may respond to a regimen combining two targeted agents that have little or no activity when administered individually.

Trial registration
ClinicalTrials.gov ID NCT03772925, first posted 12/12/2018; CTEP Identifier 10246.
Tick salivary cystatin Iristatin limits the virus replication in skin of tick-borne encephalitis virus–infected mice
Authors: Langhansová Helena , Beránková Zuzana , Khanna Ritesh , Kotál Jan , Kotsyfakis Michail , Palus Martin , Lieskovská Jaroslava 
Published: January 2025

Abstract
Tick-borne encephalitis virus (TBEV) is flavivirus transmitted to the host via tick saliva which contains various molecules with biological impacts. One of such molecules is Iristatin, a cysteine protease inhibitor from Ixodes ricinus that has been shown to have immunomodulatory properties. To characterize Iristatin in the relation to TBEV, we investigate whether this tick inhibitor has any capacity to influence TBEV infection. Mice were intradermally infected by TBEV with or without Iristatin and the viral multiplication was determined in skin and brain tissues by RT-PCR two and 5 days after infection. The viral RNA was detected in both intervals in skin and increased by time. The application of Iristatin caused a reduction in viral RNA in skin but not in the brain of infected mice 5 days post-infection. Moreover, anti-viral effect of Iristatin on skin was accompanied by a significant decline of interferon-stimulated gene 15 gene expression. The effect of Iristatin on TBEV replication was tested also in vitro in primary macrophages and dendritic cells; however, no changes were observed suggesting no direct interference of Iristatin with virus replication. Still, the Iristatin caused a suppression of Erk1/2 phosphorylation in TBEV-infected dendritic cells and had the anti-apoptotic effect. This is the first report showing that a tick cystatin decreases the viral RNA in the host skin, likely indirectly through creating skin environment that is less supportive for TBEV replication. Assuming, that viral RNA reflects the amount of infectious virus, decline of TBEV in host skin could influence the tick biology or virus transmission during cofeeding.
Assessing the subarachnoid space anatomy on clinical imaging: utilizing normal and pathology to understand compartmentalization of the subarachnoid space
Authors: Almohaimede Khaled , Alibrahim Yusuf , Butt Abu Bakar , Maralani Pejman , Heyn Chris , Kapadia Anish 
Published: January 2025

Abstract

Background
The goal of the study is to use CT imaging in patients with aSAH to evaluate the anatomic distribution of hemorrhage and compartmentalization of subarachnoid space to investigate potential in vivo visualization of recently discovered layer named subarachnoid lymphatic-like membrane (SLYM).

Methods
We conducted a retrospective cohort study of cases with aneurysmal SAH (aSAH) at our institution between January 2015 and June 2022. Subarachnoid hemorrhage distribution into superficial and deep subarachnoid spaces was classified based on proximity to the dural or pial surfaces, respectively, as seen on multiplanar CT head.

Results
A total of 97 patients with aSAH were included. Patients with lower modified Fisher score (MFS) of 1-2 were more likely to have SAH compartmentalizing in the “deep” pial-adjacent subarachnoid space. Patients with higher MFS of 3-4 were more likely to have SAH in both “superficial” and “deep” compartments along the brainstem. There is a significant association between the severity of aSAH - quantified by the MFS - and the distribution of the blood. Patients with higher MFS scores were roughly 7.6 times (p-value = 0.049) more likely to have hemorrhage at the “Superficial” juxta-dural subarachnoid compartment when compared to those with lower MFS scores.

Conclusion
This study suggests an imaging correlate to the recently discovered “SLYM”, potentially influencing aSAH compartmentalization, particularly in low-grade bleeds. While compartmentalization is limited in high grade cases, these findings warrant further investigation with advanced imaging techniques to validate this membrane’s role and potential impact on CSF flow and aSAH pathophysiology.
Preparing for Digital Learning Monitoring in the Fraction Context: Assessment of Students’ Prior Knowledge According to Evidence-Based Cognitive Models
Authors: Schadl Constanze , Lindmeier Anke 
Published: January 2025

Abstract
Regularly assessing students’ learning using evidence-based cognitive models can enhance learning by supporting teachers’ monitoring and scaffolding decisions. In the case of mathematics, this is considered especially essential for topics renowned as being complex for students, like fractions. Although previous findings from paper-based studies yielded sophisticated cognitive models, they were not consistently related so far to evidence-based assessment approaches. Also, as paper-based testing appears resource-consuming, its practical use is hindered. Addressing this gap, we developed instruments for digital evidence-based assessment. This paper focuses on the psychometric quality of two tests assessing prior knowledge of fractions: symbolic multiplication and division skills (SMDS) and proportional reasoning skills (PRS). Using item-response-theory-methods to analyze data from N = 147 fifth graders, the digital SMDS-test showed good reliability and validity. The findings suggest a specific item subset suited as an efficient short test. Regarding PRS, further adaptation of the digital format is advised.
The Root of All Evil: Money as the Common Driver of Climate Change and Loss of Diversity
Authors: Hornborg Alf 
Published: January 2025

Abstract
The paper traces the common roots of climate change and diversity loss to the phenomenon of general-purpose money, viewed as a recent addition to the biosemiotics of the planet. Money is the driver of increasing greenhouse gas emissions as well as the homogenizing processes of globalization. From an evolutionary perspective, the money sign can be understood as emerging from the human capacity for symbolism, yet it is not itself a symbol, as it can be given any meaning that its owner wishes. The appearance of money has fundamentally transformed social and human-environmental relations, coinciding with a loss of concern about morally compelling forces in nature. As Marx observed, in exemplifying how human artifacts that are contingent on social relations are perceived as powerful in themselves, money is an instance of fetishism. In serving as a veil that obscures the asymmetric global trade in embodied labor and other biophysical resources, money prices are also the condition for technological fetishism. Money is central to the social condition of modernity and the decontextualizing logic of the market, which tends to reduce both biological and cultural diversity. In contrast, Indigenous societies suggest alternatives to monetization and homogenization, prompting us to revise aspects of our modern worldview.
Investigation of the effect of catalyst support on oleic acid catalytic deoxygenation for green diesel production
Authors: Siraj Mohammed , Ceylan Selim 
Published: January 2025

Abstract
The presence of certain oxygenated species has led to the development of green diesel produced using deoxygenation (DO) technology to replace conventional biodiesel. The study focused on the effects of the supports on the deoxygenation of oleic acid using the CoMo catalyst. The results of this study revealed that the Molybdenum and Cobalt species have a significant influence on the reactivity and distribution of the product. The CoMo-based catalyst supported on Cerium oxide (CeO2), Titanium dioxide (TiO2), activated carbon (AC), and Aluminum oxide (Al2O3) were prepared by wet impregnation method and then calcinated under 20 mL min−1 N2 flow for 4 h at a temperature of 550 °C. The prepared catalysts were characterized by X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET), Thermo-Gravimetric Analysis (TGA), and Scanning Electron Microscopy (SEM) analysis. The influence of support type (activated carbon, Al2O2, CeO2, and TiO2) on the removal of various oxygenated functional groups was examined during the deoxygenation of oleic acid using supported CoMo catalysts at 350 °C and atmospheric pressure. The deoxygenated liquid products were characterized by Fourier-transform infrared spectroscopy (FTIR), Gas Chromatography–Mass Spectrometry (GC–MS), Higher heating value (HHV), and CHNOS analysis. The yield of hydrocarbons increased in the order Blank < CoMo/TiO2 < CoMo/CeO2 < CoMo/Al2O3 < CoMo/AC. Based on the study results, CoMo/AC is the most active catalyst with 93.20% hydrocarbon yield for 2 h. at 350 °C and 300 rpm in the absence of hydrogen. However, a significant deoxygenation reaction was still observed for the catalysts having CoMo supported on Al2O3, CeO2, and TiO2. In summary, CoMo/AC demonstrates better catalytic performance, attributed to its favorable physicochemical properties.
Psychometric Properties and Network Analysis of the Arabic Version of Reinforcement Sensitivity Theory of Personality Scale-Short Version in Patients with Anxiety Disorders
Authors: Abdelrahman Rasha Mohamed , Fakhrou Abdulnaser , Moussa Mahmoud Ali , Roshan Mohaddeseh 
Published: January 2025

Abstract
This study aimed to examine the psychometric properties of the Arabic version of a short version of the Reinforcement Sensitivity Theory of Personality Questionnaire (RST-PQ-S) among a sample of 700 patients with anxiety disorders (53.1% were female). Participants completed the RST-PQ-S, NEO-FFI, Positive Mental Health (PMH), and Kessler Psychological Distress scale. Both Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were employed to test the construct validity of the scale. This study also utilized a network perspective, incorporating Exploratory Graph Analysis (EGA) and centrality measures. As a result of the EFA and CFA, it was determined that the scale consists of 22 items and six subdimensions. These subdimensions were named as follows: “Flight Fight-Freeze System”, “Behavioral Inhibition System”, “Reward Interest”, “Reward Reactivity”, “Goal-Drive Persistence”, and “Impulsivity”. Additionally, the network analysis’s findings confirmed the six-factor structure derived from the construct validity assessment. The results of this study demonstrated that the Arabic version of the personality scale is a valid and reliable tool for assessing personality in Arabic-speaking individuals with anxiety disorders. It has the potential to serve as an important diagnostic instrument in clinical and research settings. These findings may assist psychologists and clinicians in Arabic-speaking countries to better understand how the personality traits and anxiety disorders are related.
Case Study Pedagogy in Disaster Education
Authors: Srigyan Prerna , Fortun Kim 
Published: January 2025

Abstract
Research in cultural anthropology and the interdisciplinary field of science and technology studies (STS) has demonstrated that environmental disasters are not only techno-scientifically and socio-politically complex but also epistemically complex -- involving perspectival diversity; multiple, often conflicting forms of evidence; data gaps and disinformation; and role transitions and confusions. Disasters, this research has demonstrated, are highly fraught knowledge problems that nevertheless call for pragmatic response. In this article, we describe an approach to disaster education that stems from this premise, mobilizing an Environmental Injustice Case Study Framework that draws out multiple dimensions of disaster, foregrounding the need for interdisciplinarity while immersing students in the challenges and paradoxes of disaster knowledge production. We offer both an instructional approach and a theoretical perspective on what case study pedagogy in disaster education accomplishes, and can contribute to science education writ large. Our argument is that critical approaches to case study pedagogy can scaffold many kinds of learning in both disaster and science education, helping students integrate diverse kinds of data, analysis, interpretation, and judgment, while building metacognition and epistemic reflexivity.