bluuebunny/crossref_metadata_2025_split huggingface dataset:
Action Planning for Building Program Sustainability: Results from a Group-Randomized Trial
Authors: Moreland-Russell Sarah , Combs Todd , Gannon Jessica , Jost Eliot , Saliba Louise Farah , Prewitt Kimberly , Luke Douglas , Brownson Ross C 
Published: May 2023

Abstract
Background: Public health programs are charged with implementing evidence-based interventions to support public health improvement, however, to achieve long term population based benefit these interventions must be sustained. Empirical evidence suggests that program sustainability can be improved through training and technical assistance, but few resources are available to support public health programs in building capacity for sustainability.
Methods: This study sought to build capacity for sustainability among state tobacco control programs through a multiyear, group-randomized trial that developed, tested, and evaluated a novel Program Sustainability Action Planning Model and Training Curricula. Using Kolb’s experiential learning theory, we developed this action-oriented training model to address the program-related domains proven to impact capacity for sustainability as outlined in the Program Sustainability Framework. We evaluated the intervention using a longitudinal mixed-effects model using Program Sustainability Assessment (PSAT) scores from three time points. The main predictors in our model included group (control vs intervention) and type of dosage (active and passive). Covariates included state level American Lung Association score (proxy for tobacco control policy environment) and percent of CDC-recommended funding (proxy for program resources).
Results: Twenty-three of the 24 state tobacco control programs were included in the analyses: 11 received the training intervention and 12 were control. Results of the longitudinal mixed-effects linear regression model, where the annual PSAT score was the outcome, showed that states in the intervention condition reported significantly higher PSAT scores. The effects for CDC-recommended funding and American Lung Association smoke-free scores (proxy for policy environment) were small but statistically significant.
Conclusion: This study found that the Program Sustainability Action Planning Model and Training Curricula was effective in building capacity for sustainability. The training was most beneficial for programs that had made less policy progress than others, implying that tailored training may be most appropriate for programs possibly struggling to make progress. Finally, while funding had a small, statistically significant effect in our model, it virtually made no difference for the average program in our study. This suggests that other factors may be more or equally important as the level of funding a program receives.
Trial registration: NCT03598114, Registered on July 26, 2018 (clnicaltrials.gov/NCT03598114)
A novel multi-antigenic parapoxvirus-based vaccine demonstrates efficacy in protecting hamsters and non-human primates against SARS-CoV-2 challenge
Authors: Reguzova Alena , Sigle Melanie , Pagallies Felix , Salomon Ferdinand , Rziha Hanns-Joachim , Bittner-Schrader Zsofia , Verstrepen Babs , Böszörményi Kinga , Verschoor Ernst , Elbers Knut , Esen Meral , Manenti Alessandro , Monti Martina , Derouazi Madiha , Rammensee Hans-Georg , Löffler Markus , Amann Ralf 
Published: May 2023

Abstract
The next generation of COVID-19 vaccines needs to broaden the antigenic repertoire to improve breadth of immune response and efficacy against emerging variants of concern. This study describes a new parapoxvirus-based vector (ORFV) as a platform to design a multi-antigenic vaccine targeting SARS-CoV-2 spike and nucleocapsid antigens. Two vaccine candidates were engineered, one expressing spike protein alone (ORFV-S) and the other co-expressing the more conserved nucleocapsid protein (ORFV-S/N). Both vaccines elicited comparable levels of spike-specific antibodies and virus neutralization in mice. In a SARS-CoV-2 challenge model in hamsters, the multi-antigenic ORFV-S/N vaccine conferred protection in the upper and lower respiratory tract, while the ORFV-S-vaccinated animals showed protection restricted to the lungs. Similarly, in a non-human primates challenge model, vaccination with the ORFV-S/N vaccine resulted in rapid onset and long-term protection against SARS-CoV-2 infection. These results demonstrate the potential of ORFV as a platform for prophylactic vaccination and support ongoing first-in-man studies with the multi-antigenic ORFV vaccine.
Assessment of cyanotoxins in water and fish in an African freshwater lagoon (Lagoon Aghien, Ivory Coast) and the application of WHO guidelines
Authors: Yao Eric Kouamé , Ahoutou Mathias Koffi , Olokotum Mark , Hamlaoui Sahima , Lance Emilie , Marie Benjamin , Bernard Cecile , Djeha Rosine Yao , Quiblier Catherine , Humbert Jean-François , Coulibaly Julien Kalpy 
Published: May 2023

Abstract

In comparison with northern countries, limited data are available on the occurrence and potential toxicity of cyanobacterial blooms in lakes and ponds in Sub-Saharan countries. With the aim of enhancing our knowledge on cyanobacteria and their toxins in Africa, we performed a 17-month monitoring of a freshwater ecosystem, Lagoon Aghien (Ivory Coast), which is used for multiple practices by riverine populations and for drinking water production in Abidjan city. The richness and diversity of the cyanobacterial community were high and displayed few variations during the entire survey. The monthly average abundances ranged from 4.1x104 cell mL− 1 to 1.8x105 cell mL− 1, with higher abundances recorded during the dry seasons. Among the five cyanotoxin families analyzed, only microcystins (MC) were detected with concentrations ranging from 0 to 0.364 µg L− 1 in phytoplankton cells, from 32 to 1,092 µg kg− 1 fresh weight of fish intestines and from 33 to 383 µg kg− 1 in fish livers. Even if the MC concentrations in water and fish are low, usually below the thresholds defined in WHO guidelines, these data raise the issue of the relevance of these WHO guidelines for Sub-Saharan Africa, where local populations are exposed throughout the year to these toxins in multiple ways.
Effect of manual therapy on tinnitus in patients with TMJ
Authors: Kmeid Elio , Fersan Gerard , Romanos³ Michael , Tawk Mirna , Jalkh Edmond 
Published: May 2023

Abstract
Background: Temporomandibular joint disorder (TMD) is a frequent manifestation in the Lebanese population. It comes up frequently as a diagnosis for a myriad of symptoms. Tinnitus, along with headaches and referred otalgia are among the common presentations.
Methods: A retrospective study investigated the difference in tinnitus severity between physiotherapy (interventional group) and the control group (no intervention) in patients with TMJ using the Tinnitus Handicap Inventory (THI) score.
Results: THI was significantly reduced in the physiotherapy group. Gender appears to affect the outcome in favor of women, most likely due to their positive response to physiotherapy.
Conclusion: Physiotherapy along with patient education about oral parafunctional habits significantly reduces the severity of tinnitus. Females appear to benefit more than males, most likely due to their positive response to initiating therapy.
Identification of crosstalk and immune related genes between Periodontitis and Rheumatoid Arthritis and construction of the ceRNA Network
Authors: Zhao Xiaoxue , Zhang Xinran , Zhang Tingting 
Published: May 2023

Abstract
Background and Objectives
Our investigation intended to explore the association of immune regulatory factors between PD and RA.
Methods
The PD and RA expression data were obtained from GEO database. The differentially expressed mRNAs(DEGs) were identified and significant modules on both diseases were selected by WGCNA. Four key genes were analyzed by the ROC, gene correlation and external datasets. Single gene GSEA was used to conduct a functional enrichment analysis. The ceRNA networks were established. CIBERSOFT algorithm and Toxicogenomics analysis were performed to show the difference and similarity between both diseases.
Results
Four key genes (IL10RA, RAC2, BTK and CD48) were identified. Two target miRNAs of key genes, hsa-miR-1271-5p and hsa-let-7e-5p, were analyzed to build 9 lncRNA- 2 miRNA- 4 genes ceRNA networks on PD and 16 lncRNA-2 miRNA-4 genes ceRNA network on RA. Four key genes represented a higher diagnostic accuracy and higher correction with each other on both diseases. GSEA result expressed key genes were involved in different pathways on both disease. The similarity and difference in the immunocytes infiltration levels of PD and RA were observed.
Conclusions
We identified four key genes and built ceRNA networks separately. Our study attempted to elaborate the common immune related mechanism of association between PD and RA.
Capacity Analysis and Determinants of the Global Covid-19 Vaccine Distribution Process
Authors: Hegde Sharika J. , Ng Max T.M. , Rios Marcos , Mahmassani Hani S. , Chen Ying , Smilowitz Karen 
Published: May 2023

Abstract
The COVID-19 vaccine development, manufacturing, transportation, and administration proved an extreme logistics operation of global magnitude. Global vaccination levels, however, remain a key concern in preventing the emergence of new strains and minimizing the impact of the pandemic’s disruption of daily life. In this paper, country-level vaccination rates are analyzed through a queuing framework to extract service rates that represent the practical capacity of a country to administer vaccines. These rates are further characterized through regression and interpretable machine learning methods with country-level demographic, governmental, and socio-economic variates. Model results show that participation in multi-governmental collaborations such as COVAX may improve the ability to vaccinate. Similarly, improved transportation and accessibility variates such as roads per area for low-income countries and rail lines per area for high-income countries can improve rates. It was also found that for low-income countries specifically, improvements in basic and health infrastructure (as measured through spending on healthcare, number of doctors and hospital beds per 100k, population percent with access to electricity, life expectancy, and vehicles per 1000 people) resulted in higher vaccination rates. Of the high-income countries, those with larger 65 + populations struggled to vaccinate at high rates, indicating potential accessibility issues for the elderly. This study finds that improving basic and health infrastructure, focusing on accessibility in the last mile, particularly for the elderly, and fostering global partnerships can improve logistical operations of such a scale. Such structural impediments and inequities in global health care must be addressed in preparation for future global public health crises.
Inter-rater reliability and preparation features for diverse grading scales analyzing computer-based grading of 1465 preparations Running title: Inter-rater reliability and preparation features analyzing 1465 preparations
Authors: Liebermann Anja , Winter Anna , Schmid-Zellner Stefanie , Le Vinzenz , Erdelt Kurt 
Published: May 2023

Abstract

Background:Preparation exercises represent an essential part in the study of dentistry. Digital grading software can be used for evaluation of prepared artificial teeth, which is mainly based on limited number of teeth and raters. In order to improve a standardized evaluation of preparations, the aim of this study was to assess the inter-rater reliability of a high number of teeth by different raters and, to evaluate specific preparation features.Methods:Therefore, a total of 1465 preparations of an artificial lower molar were evaluated with grades from 1 to 5 by four dentists out of three dental schools, and inter-rater reliability was calculated. A specific analysis program was used for objective evaluation of the preparation. Data were analyzed using the Kolmogorov-Smirnov test, Pearson chi-square test, and reliability analysis with a level of significance of p= 0.05.Results:The median value of all grades was 2.75 (IQR: 1.35). Lowest grade variance of 0.00 within the raters’ evaluations was observed in grade group 1. Grade variance of evaluations with grades 1 and 2 differed significantly from all the other grade groups (p≤0.003). The inter-rater reliability factor of all grade groups together was 0.958.Conclusion:Inter-rater reliability was very high, which indicates very good correlation of the given grades. The objective evaluation of preparation features has worsened with ascending grade groups. Significant differences within the grade groups indicate higher agreement when evaluating good preparations. The objective feature convergence and preparation angle, marginal width, and stump height have a crucial impact on evaluation.
When Indian mother delivers neonates larger than 4000 grams: Possibly maternal characteristics and newborn’s sex play decisive role associated with fetal macrosomia
Authors: Das Priya , Das Tanu , Das Partha , Saha Subhadeep , Roy Tamal Basu 
Published: May 2023

Abstract

Background
A new born’s birth weight occur ≥ 4000 grams is defined as fetal macrosomia, recognized as a serious reproductive and child health problem, directly or indirectly can contribute to severe maternal, fetal and neonatal morbidity, mortality and disability worldwide.
Objectives
Our present study aims to analyse the role of maternal factors and newborn’s sex resulting fetal macrosomia in Indian context.
Methods
Data were drawn from the fifth round of National Family Health Survey (NFHS-5), conducted in India during 2019–2021. A cross-sectional observational study was carried out with a total of 152, 827 children born to women in reproductive age group (15–49) who had most recent live birth in the past five years preceding the survey. Descriptive analyses, cross-tabulation, test of association through Pearson’s chi-squared test and finally binary logistic regression analyses were performed to fulfil the study objectives.
Results
In India, the prevalence of macrosomia was found 3% of total study participants (n = 152,827). Considering new born characteristics, fetal macrosomia was prevalent among the male neonates. Giving importance regarding maternal characteristics, overweight and obese mothers, having gestational diabetes and hypertension were more vulnerable to give birth of macrosomic babies. Besides, the multiparous mothers and the women who did not undergo through proper ANC follow up, had also greater risks of developing fetal macrosomia. Even, muslim women, and women belonged to scheduled tribe category were significantly associated with the risk of having fetal macrosomia.
Which comorbidity index is more appropriate for geriatric patients from the frailty perspective?
Authors: HAFIZOGLU Merve , Cömertoğlu Ezgi Odacı , Öztürk Yelda , Kahyaoğlu Zeynep , Çavuşoğlu Çağatay , Balcı Cafer , Halil Meltem Gülhan , Aki Özlem Erden , Cankurtaran Mustafa , Dogu Burcu Balam 
Published: May 2023

Abstract

Objectives: This study examined the relationship between comorbidity indices and comprehensive geriatric assessment including psychologic, social frailty, and geropsychiatric evaluation.
Methods: A cross-sectional analysis was conducted with 136 community-dwelling older adults. The relationship of 4 comorbidity indices (CIRS-G, ACCI, GIC, ICED) with 3 different frailty scales (FRAIL, CFS, TFI) was examined.
Results: Overall, 58.8% of the participants were living with frailty according to the TFI, 47.7% of them living with psychological frailty, and 28.6% of them living with social frailty. There were significant and moderate correlations between CIRS-G and FRAIL, CFS and TFI total scores, TFI-Psychological scores and TFI-Social scores (respectively; p<0.001, r = 0.530; p<0.001, r = 0.471; p<0.001, r = 0.535; p<0.001, r = 0.402; p= 0.016 r = 0.206). AUC for CIRS-G was calculated as 0.746 among comorbidity indices in predicting the presence of frailty according to the TFI (p<0.001, 95%CI [0.66-0.82]), for ACCI AUC was 0.631 (p=0.01, 95%CI [0.53-0.72]), for GIC AUC was 0.595 (p=0.059, 95%CI [0.49-0.69]), for ICED AUC was 0.666 (p=0.001, 95%CI [0.57-0.75]).
Conclusion: The CIRS-G index was found to be superior to other indices in predicting the presence of frailty of comorbidity indices, and only GIC scores showed significant results in predicting mortality. However, it would be incomplete to conclude with a comorbidity index alone by ignoring the results of comprehensive geriatric assessment.
Suicidal behaviors among active-duty U.S. service members: data from the 2018 Health Related Behaviors Survey
Authors: Ahmed Anwar , Yim Michael , Dawood Jimmy , Olsen Cara , Waters Andrew , Singer Darrell , Mancuso James 
Published: May 2023

Abstract
Background
From 2006–2021, suicide was the second leading cause of death among U.S. active-duty military service members (SMs). This study aimed to determine the prevalence of past-year suicidal ideation (SI) and attempts (SA) among active-duty SMs; to determine whether differences exist by age, sex, and race; and to assess whether prevalence estimates vary by risk profiles of mental health conditions and substance use.
Method
Data were from the 2018 Health-Related Behaviors Survey (HRBS), a cross-sectional survey of active-duty SMs (n = 17,166). We used the logistic model to identify factors of SI and SA and latent class analysis (LCA) to identify the risk profiles.
RESULTS
Among active duty SMs, 8.26% had SI and 1.25% had SA in the past year. Among SMs with past-year SI, 14.19% attempted suicide. Mental health conditions were associated with higher odds of SI and SA, as were younger ages; LGB identity; being separated, divorced, or widowed; use of e-cigarettes, dual use of e-cigarettes and cigarettes, or drugs; and history of deployment of less than 12 months. The LCA identified patterns of SI and SA according to illegal drug use, tobacco use, alcohol use, and mental health risk profiles.
Conclusions
Despite the resources and increased access provided for mental health support, the prevalence of SI among active-duty SMs is greater than in the general population of the same age, likely due to additional military exposures and stressors. This study highlights the need for intensive interventions to detect, mitigate and prevent suicidal behaviors, particularly among those with higher risk profiles.
Visualization and Analysis of Gene Expression in Calcific Aortic Valve Tissue Section by Spatial Transcriptomics
Authors: Liu Shaoyan , Wang Ai , Zhai Changlin , Zhao Yun , Chen Jiehui , Yang Zhaohua , Lan Yang , Lin Tzuchun , Lin Kaibin , Zhang Qianyu , Hu Huilin , Yan Yan 
Published: May 2023

Abstract
Background: To identify the aortic valve spatial location information through spatial transcriptomics (ST) technology and explore the spatial expression and role in valve calcification of the key factors at the transcriptome-wide scales, thus providing new insight for clinical prevention and treatment of calcific aortic valve disease (CAVD).
Methods: Six cases of human active valve stenosis calcified valves from valve replacement surgery and two cases of relatively normal aortic valves from heart transplantation were collected between March 1, 2021 and September 1, 2021. We constructed tissue-wide gene expression sequencing during aortic valve calcification formation using ST and performed comprehensive mapping of differentiation transitions and spatial expression information in the calcified area of the valve.
Results: We identified 6736 genes based on the count level of gene expression at different locations and obtained the spatial distribution map of the three-layer structure of the main 9 cells of the aortic valve during the formation of valve calcification and proportions of aortic valves. Shear stress factors were significantly enriched in the aortic valve. The differential expression of TRP family genes was significantly based on spatial transcriptome analysis.
Conclusion: Herein, we elucidated the spatial resolution of the transcriptome and tissue scope of the adult aortic valve, providing a basis for a better understanding of the cellular origin and complex cytopathological differentiation process of CAVD. Our findings further the understanding of the pathogenesis and heterogeneity of aortic valve calcification and the implementation of more effective personalized treatment methods.
An ensemble surrogate-assisted adaptive reference point guided evolutionary algorithm for expensive many-objective irregular problem
Authors: You Xiongxiong , Niu Zhanwen , Tang Diyin , Zhang Mengya 
Published: May 2023

Abstract

Surrogate-assisted evolutionary algorithms (SAEAs) are one effective method for solving expensive optimization problems. However, there has been little attention to expensive many-objective irregular problems. To address this issue, we propose an ensemble surrogate-assisted adaptive reference point guided evolutionary algorithm for dealing with expensive many-objective irregular problems. Firstly, a reference point adaptation method is adopted in the proposed algorithm to adjust the reference point for calculating indicators and guide the search process. Secondly, the enhanced inverted generational distance (IGD-NS) indicator is improved by using the modified distance to obey the Pareto compliant, which can maintain a balance between convergence and diversity in the population. Thirdly, an infill sampling criterion is designed to select elite individuals for re-evaluation in case the Pareto fronts are irregular. The added elite individuals update the ensemble surrogate model, which is expected to assist the algorithm in efficiently finding the Pareto optimal solutions in a limited computational resource. Finally, experimental results on several benchmark problems demonstrate that the proposed algorithm performs well in solving expensive many-objective optimization problems with irregular and regular Pareto fronts. A real-world application problem also confirms the effectiveness and competitiveness of the proposed algorithm.