bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Oral Anticoagulation Versus Warfarin in Left Ventricular Thrombus: Pooled Analysis of Randomized Controlled Trials
Authors: Sahlén Anders Olof , Jiang Haowen , Lau Yee How , Cuenza Lucky , Cader F. Aaysha , Al‐Omary Mohammed , Surunchupakorn Purich , Ho Ka Hei , Sung Jonathan , Lee Derek , Honda Satoshi , Tan Wei Chieh Jack , Yap Jonathan 
Published: May 2023

AbstractPatients with impaired left ventricular (LV) function can develop LV thrombus, a potentially life‐threatening condition due to risk of stroke and embolization. Conventional treatment with vitamin K antagonists (VKAs; e.g., warfarin) puts patients at risk of bleeding, and the use of direct oral anticoagulants (DOACs) appears promising, although data are scant. We searched the published English language literature for randomized controlled trials (RCTs) comparing DOACs with VKAs in LV thrombus. End points were failure to resolve, thromboembolic events (stroke, embolism), bleeding, or any adverse event (composite of thromboembolism or bleeding), or all‐cause death. Data were pooled and analyzed in hierarchical Bayesian models. In three eligible RCTs, 141 patients were studied during an average of 4.6 months (53.8 patient‐years; n = 71 assigned to DOAC, n = 70 assigned to VKA). A similar number of patients in each treatment arm demonstrated failure to resolve (DOAC: 14/71 vs. VKA: 15/70) and death events (3/71 vs. 4/70). However, patients on DOACs suffered fewer strokes/thromboembolic events (1/71 vs. 7/70; log odds ratio [OR], −2.02 [95% credible interval (CI95), −4.53 to −0.31]) and fewer bleeding events (2/71 vs. 9/70; log OR, −1.62 [CI95, −3.43 to −0.26]), leading to fewer patients on DOACs with any adverse event versus VKAs (3/71 vs. 16/70; log OR, −1.93 [CI95, −3.33 to −0.75]). In conclusion, pooled analysis of RCT data favors DOACs over VKAs in patients with LV thrombus in terms of both efficacy and safety.
The miR‐126‐5p and miR‐212‐3p in the extracellular vesicles activate monocytes in the early stage of radiation‐induced vascular inflammation implicated in atherosclerosis
Authors: Choi You Yeon , Kim Areumnuri , Lee Younghyun , Lee Yang Hee , Park Mineon , Shin Eunguk , Park Sunhoo , Youn BuHyun , Seong Ki Moon 
Published: May 2023

AbstractPeople exposed to radiation in cancer therapy and nuclear accidents are at increased risk of cardiovascular outcomes in long‐term survivors. Extracellular vesicles (EVs) are involved in radiation‐induced endothelial dysfunction, but their role in the early stage of vascular inflammation after radiation exposure remains to be fully understood. Herein, we demonstrate that endothelial cell‐derived EVs containing miRNAs initiate monocyte activation in radiation‐induced vascular inflammation. In vitro co‐culture and in vivo experimental data showed that endothelial EVs can be sensitively increased by radiation exposure in a dose‐dependent manner, and stimulate monocytes releasing monocytic EVs and adhesion to endothelial cells together with an increase in the expression of genes encoding specific ligands for cell‐cell interaction. Small RNA sequencing and transfection using mimics and inhibitors explained that miR‐126‐5p and miR‐212‐3p enriched in endothelial EVs initiate vascular inflammation by monocyte activation after radiation exposure. Moreover, miR‐126‐5p could be detected in the circulating endothelial EVs of radiation‐induced atherosclerosis model mice, which was found to be tightly correlated with the atherogenic index of plasma. In summary, our study showed that miR‐126‐5p and miR‐212‐3p present in the endothelial EVs mediate the inflammatory signals to activate monocytes in radiation‐induced vascular injury. A better understanding of the circulating endothelial EVs content can promote their use as diagnostic and prognostic biomarkers for atherosclerosis after radiation exposure.
Distribution of cervical intraepithelial neoplasia is closely associated with HPV status and uterine position
Authors: Tamura Daisuke , Sako Wataru , Watanabe Rina , Shitara Akihiro , Saito Fumiko , Yamauchi Misa , Sugita Akihiro , Karube Akihiro 
Published: May 2023

AbstractAlthough cervical intraepithelial neoplasia (CIN) lesions are considered to be not randomly distributed across the cervix, but predominantly in the anterior wall, the clinicopathological etiology remains unknown. Herein, we aimed to elucidate the relationship between quantitatively measured area of CIN2/3 and cervical cancer associated factors by retrospective cohort study. We analyzed 235 consecutive therapeutic conization specimens dissected as a single intact section to determine CIN2/3 area and its correlation with both clinical risk factors including human papillomavirus (HPV) status (single or multiple infection) and uterine position defined by transvaginal ultrasound. Cervical wall was classified into three groups: anterior: (11, 12, 1, and 2 o'clock), posterior (5, 6, 7, and 8 o'clock) and lateral (3, 4, 9, and 10 o'clock). Multiple regression revealed that younger age and HPV16 status were significantly correlated with CIN2/3 area (p = 0.0224 and p = 0.0075, respectively). The Jonckheere‐Terpstra test showed a significant trend: CIN2/3 area was highest in the single HPV16 group, followed by the multiple HPV16 group and the non‐HPV16 group (p < 0.0001). CIN2/3 area in the anterior wall was statistically significantly larger than the posterior and lateral wall (p = 0.0059 and p = 0.0107, respectively). CIN2/3 area in the anterior wall was significantly greater with anteversion‐anteflexion than retroversion‐retroflexion (p = 0.0485), whereas CIN2/3 area in the posterior wall was significantly larger with retroversion‐retroflexion than anteversion‐anteflexion (p = 0.0394). In conclusion, the topographical distribution of CIN2/3 area is closely associated with patient age, high‐risk HPV status, especially single HPV16 infection and uterine position.
A novel film based on gluten, pectin, and polyphenols and its potential application in high‐fat food
Authors: Xu Qian‐Da , Jing Zan , He Qiang , Zeng Wei‐Cai 
Published: May 2023

AbstractBACKGROUNDA novel film based on some natural ingredients (wheat gluten, pectin, and polyphenols) was used to improve the quality and storage stability of high‐fat food due to their good sustainable, mechanical, and edible properties.RESULTSWith the addition of polyphenols from Cedrus deodara (in the form of pine‐needle extract (PNE)), the physicochemical properties (thickness, moisture content, and color), mechanical properties (tensile strength and elongation), barrier properties (water vapor, oil, and oxygen permeability, transmittance), and thermal stability of the composite film were improved. According to the analysis of infrared spectroscopy and molecular docking, the main compounds of PNE interacted with wheat gluten by hydrogen bonds and hydrophobic forces to form a compact and stable structure. In addition, the composite film showed a remarkable antioxidant capability to scavenge free radicals, and the film matrix could effectively protect the antioxidant activity of PNE. Furthermore, using cured meat as a model, the composite film exhibited a fine packaging performance in high‐fat food during storage, which could obviously inhibit the excessive oxidation of fat and protein of cured meat and was beneficial in forming its special flavor.CONCLUSIONOur results suggest that the composite film possessed good properties and had potential for packing of high‐fat foods, which could improve the quality and safety of food during processing and storage. © 2023 Society of Chemical Industry.
Use of soybean oil to modulate the gel properties of soybean protein isolation‐wheat gluten composite with or without CaCl2
Authors: Lian Wentao , WangFeng Qiujie , Zhang Haojia , Zhu Ying , Qu Min , Sun Bingyu , Huang Yuyang , Zhu Xiuqing 
Published: May 2023

AbstractBACKGROUNDPlant protein is widely used in the study of animal protein substitutes and healthy sustainable products. The gel properties are crucial for the production of plant protein foods. Therefore, the present study investigated the use of soybean oil to modulate the gel properties of soybean protein isolation‐wheat gluten composite with or without CaCl2.RESULTSOil droplets filled protein network pores under the addition of soybean oil (1–2%). This resulted in an enhanced gel hardness and water holding capacity. Further addition of soybean oil (3–4%), oil droplets and some protein–oil compounds increased the distance between the protein molecule chain. The results of Fourier transform infrared spectroscopy and intermolecular interaction also showed that the disulfide bond and β‐sheet ratio decreased in the gel system, which damaged the overall structure of the gel network. Compared with the addition of 0 m CaCl2, salt ion reduced the electrostatic repulsion between proteins, and local protein cross‐linking was more intense at 0.005 m CaCl2 concentration. In the present study, structural properties and rheological analysis showed that the overall strength of the gel was weakened after the addition of CaCl2.CONCLUSIONThe presence of appropriate amount of soybean oil can fill the gel pores and improve the texture properties and network structure of soy protein isolate‐wheat gluten (SPI‐WG) composite gel. Excessive soybean oil may hinder protein–protein interaction and adversely affect protein gel. In addition, the presence or absence of CaCl2 significantly affected the gelling properties of SPI‐WG composite protein gels. © 2023 Society of Chemical Industry.
Responses of biogenic dimethylated sulfur compounds to environmental changes in the northwestern Pacific continental sea
Authors: Ma Qian‐Yao , Yang Gui‐Peng 
Published: May 2023

AbstractContinental seas are facing rapid environmental shifts, but how biogenic dimethylated sulfur compounds, including dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO), will respond to these environmental changes remains poorly understood. Here we investigated the effects of nutrient input, ocean acidification, and dust deposition on the phytoplankton community and organic sulfur cycle in the East China Sea. Nutrient input promoted phytoplankton growth and increased the concentrations of DMS, DMSP, and DMSO. With sufficient nutrients, especially nitrate, the dissolved DMSP degradation was inhibited, and the bacterial DMSP‐cleavage pathway (inferred by dddP gene abundance) was enhanced, causing increased DMS production. The sensitivity of phytoplankton biomass and DMS to ocean acidification varied with different initial nutrient levels, demonstrating insensitivity under eutrophic conditions and negative responses under nutrient‐limited conditions. The ocean acidification promoted the dissolved DMSP degradation and bacterial DMSP‐demethylation pathway (inferred by dmdA gene abundance) and weakened the DMS production, causing the decreases of DMS and DMSP. The nutrient from dust deposition (2 mg L−1) was identified as the key factor in enhancing phytoplankton biomass and the organic sulfur compounds concentrations, but trace metals input from dust deposition had no significant effect. This study has identified environmental drivers and suppressors of phytoplankton and biogenic dimethylated sulfur compounds in a changing marine environment, which will enable the effective modeling of future climate change.
Biogeochemical‐Argo floats show that chlorophyll increases before carbon in the high‐latitude Southern Ocean spring bloom
Authors: Vives Clara R. , Schallenberg Christina , Strutton Peter G. , Boyd Philip W. 
Published: May 2023

AbstractIn the Southern Ocean, phytoplankton blooms are an annually recurring prominent feature that play a significant role in ocean CO2 uptake. Understanding the timing of the phytoplankton bloom is necessary to provide insights into the underlying physiological drivers, for the study of ecosystem dynamics and consequent patterns in downward carbon export. Previous studies have used chlorophyll (chl) and particulate organic carbon, from either satellites or biogeochemical‐Argo (BGC‐Argo) floats, to investigate bloom phenology, but provide inconsistent findings regarding bloom timing. Here, we compare bloom dynamics based on three diagnostics from 7114 BGC‐Argo float profiles, south of 60°S. Bloom onset consistently occurs earlier when calculated using chl than when based on phytoplankton carbon or nitrate uptake, and the decoupling increases with latitude. This suggests that phytoplankton synthesize increased chl to acclimate to low‐light conditions, before increasing their biomass. These results highlight the importance of considering phytoplankton physiology when choosing proxies for phytoplankton growth.
Nonlinear Plasmonic Meta‐Crystals with Coupling Induced Symmetry Breaking
Authors: Zhang Xuecai , Deng Junhong , Tang Yutao , Li Yang , Zhang Guanqing , Hu Zixian , Li Guixin 
Published: May 2023

AbstractSymmetry plays an important role in determining the amplitude and polarizations of nonlinear optical waves occurring in conventional crystals. While the symmetry of crystals is limited by the materials’ synthesis process, it can be easily controlled in photonic meta‐crystals. Both the linear and nonlinear optical properties of the meta‐crystals can be judiciously tailored by the local symmetry of the meta‐atoms. Here, it is demonstrated that the symmetry of the nonlinear meta‐crystals can be artificially manipulated by introducing the coupling between adjacent plasmonic meta‐atoms. By assembling the two groups of plasmonic meta‐atoms with inversion symmetry into a hexagonal boron nitride‐like lattice, the global inversion symmetry of the metasurface is broken. Second harmonic generations due to the coupling‐induced symmetry breaking are experimentally observed from the meta‐crystals. It is also found that the polarization of the second harmonic waves obey certain symmetry selection rules. The proposed methodology, which takes advantage of the coupling effects and the intrinsic nonlinearity of the plasmonic meta‐atoms, can be used to develop a variety of nonlinear nanophotonic devices with multiple functionalities.
Mapping the progress in natural fiber reinforced composites: Preparation, mechanical properties, and applications
Authors: Dev Barshan , Rahman Ashikur , Alam Rubel , Repon Reazuddin , Nawab Yasir 
Published: May 2023

AbstractExploration of natural fiber‐reinforced polymer composites (NFRPCs) in cutting‐edge applications is due to phenomenal properties, such as lightweight, low‐cost, and environmental aspects. NFs can effectively compete to the synthetic fibers in terms of mechanical, thermal and acoustic properties. As a result, the invention and innovation of natural fiber (NF) composites for commercial purposes has increased dramatically in recent years to meet the growing demand of the industrial sectors. Materials are the cornerstone of any manufacturing industry. NFRPCs are a good alternative to conventional materials because of their relatively high mechanical properties and lower production energy. NFs decrease the cost of the material by 5% while reducing the weight of the composite by 10% and the manufacturing energy by 80%. A lot of work has been done to enhance NFRPCs' mechanical properties to overcome their drawbacks, such as poor fiber‐to‐matrix adhesion, thermal stability, and moisture absorption. However, for better mechanical properties, it is crucial to understand the fibers' embedded manufacturing technique and the appropriate fiber weight percentage with appropriate matrix. This review article discusses composites made of NFs providing a comprehensive and up‐to‐date overview of the field of NFRPCs, focusing on recent advancements in preparation techniques, improvements in mechanical properties such as tensile, flexural and impact strength of NFRPCs with various fiber types, fiber weight ratio, fiber‐to‐matrix ratio for appropriate engineering applications, and elucidating future research directions by analyzing trends and challenges in the field. The aim of this review article is to provide a deep evaluation of the progress made in the field of NFRPCs, with the ultimate goal of advancing knowledge and understanding of this field.
A proteomic signature and potential pharmacological opportunities in the adaptive resistance to MEK and PI3K kinase inhibition in pancreatic cancer cells
Authors: Aguilar‐Valdés Alain , González‐Vela Francisco , Sánchez‐Vidal Hilda , Martínez‐Aguilar Juan 
Published: May 2023

AbstractPancreatic cancer is one of the most lethal cancer types and is becoming a leading cause of cancer‐related deaths. The limited benefit offered by chemotherapy agents has propelled the search for alternative approaches that target specific molecular drivers of cancer growth and progression. Mutant KRas and effector pathways Raf/MEK/ERK and PI3K/Akt are key players in pancreatic cancer; however, preclinical studies have shown adaptive tumour response to combined MEK and PI3K kinase inhibition leading to treatment resistance. There is a critical unmet need to decipher the molecular basis underlying adaptation to this targeted approach. Here, we aimed to identify common protein expression alterations associated with adaptive resistance in KRas‐mutant pancreatic cancer cells, and test if it can be overcome by selected already available small molecule drugs. We found a group of 14 proteins with common expression change in resistant cells, including KRas, caveolin‐1, filamin‐a, eplin, IGF2R and cytokeratins CK‐8, ‐18 and ‐19. Notably, several proteins have previously been observed in pancreatic cancer cells with intrinsic resistance to the combined kinase inhibition treatment, suggesting a proteomic signature. We also found that resistant cells are sensitive to small molecule drugs ERK inhibitor GDC‐0994, S6K1 inhibitor DG2 and statins.
Telerehabilitation service impact on physical function and adherence compared to face‐to‐face rehabilitation in patients with stroke: A systematic review and meta‐analysis
Authors: Sharififar Sharareh , Ghasemi Hanieh , Geis Carolyn , Azari Hassan , Adkins Lauren , Speight Bailey , Vincent Heather K. 
Published: May 2023

AbstractObjectivesThe purposes of this systematic review and meta‐analysis were to (1) appraise the available evidence of telerehabilitation program effects on functional outcomes, adherence, and patient satisfaction compared to face‐to‐face programs after stroke; and (2) provide direction for future outcome measure selection and development for clinical research purposes.TypeSystematic review and meta analysis of randomized controlled trials.Literature surveyMEDLINE, CINAHL, Embase, Scopus, Proquest Theses and Dissertations, Physiotherapy Evidence Database (PEDro), and Clinicaltrials.gov were searched for studies published in English from 1964 to the end of April 2022.MethodologyA total of 6450 studies were identified, 13 were included in the systematic review, and 10 with at least 3 reported similar outcomes were included the meta‐analysis. Methodological quality of results was evaluated using the PEDro checklist.SynthesisTelerehabilitation demonstrated equivalency in outcomes across several domains and was favored compared to conventional face to face alone or when paired with semisupervised physical therapy on Wolf Motor Function performance score (mean difference [MD] 1.69 points, 95% confidence interval [CI] 0.21–3.17) and time score (MD 2.07 seconds, 95% CI −4.04 to −0.10, Q test = 30.27, p < .001, I2 = 93%), and Functional Mobility Assessment in the upper extremities (MD 3.32 points, 95% CI 0.90–5.74, Q test = 5.60, p = .23, I2 = 29% alone or when paired with semisupervised physical therapy). The Barthel Index participation measures of function demonstrated improvement (MD 4.18 points, 95% CI, 1.79–6.57, Q test = 3.56, p = .31, I2 = 16%). Over half of summarized study ratings were determined to be of good to excellent quality (PEDro score 6.6 ± 2.3 points). Adherence varied in available studies from 75%–100%. Satisfaction levels of telerehabilitation were highly variable.ConclusionsTelerehabilitation can improve functional outcomes and promote therapy adherence after stroke. Therapy protocols and functional assessments need substantial refinement and standardization to improve interpretation and clinical outcomes.
Emerging Weyl Semimetal States in Ternary TaPxAs1−x Alloys: Insights from Electronic and Topological Analysis
Authors: Nourizadeh Samira Sadat , Vaez Aminollah , Vashaee Daryoosh 
Published: May 2023

AbstractThis study presents a thorough analysis of the electronic structures of the TaPxAs1−x series of compounds, which are of significant interest due to their potential as topological materials. Using a combination of first principles and Wannier‐based tight‐binding methods, this study investigates both the bulk and surface electronic structures of the compounds for varying compositions (x = 0, 0.25, 0.50, 0.75, 1), with a focus on their topological properties. By using chirality analysis, (111) surface electronic structure analysis, and surface Fermi arcs analysis, it is established that the TaPxAs1−x compounds exhibit topologically nontrivial behavior, characterized as Weyl semimetals (WSMs). The effect of spin–orbit coupling (SOC) on the topological properties of the compounds is further studied. In the absence of SOC, the compounds exhibit linearly dispersive fourfold degenerate points in the first Brillouin zone (FBZ) resembling Dirac semimetals. However, the introduction of SOC induces a phase transition to WSM states, with the number and position of Weyl points (WPs) varying depending on the composition of the alloy. For example, TaP has 12 WPs in the FBZ. The findings provide novel insights into the electronic properties of TaPxAs1−x compounds and their potential implications for the development of topological materials for various technological applications.
Stability analysis and fault detection filter design for discrete‐time switched systems with all modes unstable
Authors: Huang Jinjie , Hao Xianzhi , Yang Jung‐Min 
Published: May 2023

AbstractIn this article, we investigate the stabilization and fault detection problem for discrete‐time switched systems with all modes unstable. A set of mode‐dependent fault detection filters are designed with respect to each subsystem and combined with the switched system into an augmented switched system. Sufficient conditions for both guaranteeing globally uniformly asymptotically stable (GUAS) and performance of the augmented switched system are derived by utilizing the discretized Lyapunov function technique and dwell time (DT) switching strategy. A novel pair of the residual evaluation function and threshold function are also provided for improving the sensitivity and practicability of fault detection logic. Numerical experiments demonstrate the effectiveness of the proposed
method.
Fluorogenic Phenothiazine‐Derivative as Radical Sensors
Authors: Desoky Mohamed M. H. 
Published: May 2023

AbstractThis study investigates the use of 10‐(4‐butoxyphenyl)‐10H‐phenothiazine (PTZ), a phenothiazine‐based molecule, for detecting chloroform and other chlorinated hydrocarbons (CHCs). Upon exposure to these compounds to the phenothiazine‐dervitive in presence light, a significant change in emission occurs, enabling naked‐eye detection. The visual detection range of this phenothiazine derivative extends down to concentrations as low as 5 ppm. We demonstrate the one‐time use of thin‐layer chromatography paper (TLC) sensors and glass‐based sensors for on‐site detection of chlorinated hydrocarbons using a light source such as sunlight, UV‐lamp, or a solar box. Our findings suggest that this phenothiazine‐derivative has potential as a simple, low‐cost, and effective sensing platform for chlorinated solvents, with practical applications in environmental monitoring and industrial safety. Furthermore, our results provide insights into the development of molecular sensors for detecting chlorinated hydrocarbons.