bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of HLA-B27 Gene and Rheumatoid Arthritis: Analysis of Potential Role as a Predictive Biomarker
Authors: Khidhir Karzan Ghafur , Ahmad Baban , Sabir Dana Khdr 
Published: September 2023

Rheumatoid arthritis (RA) is a predominant inflammatory arthritis in human. The function of HLA-B27 gene in other types of arthritis has been studied, however, its function in RA is unclear. This study investigated the relative expression of HLA-B27 gene in RA patients compared to normal control and assesses its suitability as a biomarker for early detection of RA. Bioinformatics analysis was used to determine the profile of HLA-B27 gene in different human tumors to demonstrate the possible involvement of HLA-B27 in both RA and cancer; and also, to discover its functional association with other human genes. Samples of human blood from RA patients and healthy individuals were collected, and RNA extraction, cDNA synthesis and qPCR were carried out to detect relative expression of HLA-B27. ROC analysis was undertaken to investigate HLA-B27 diagnostic performance; GENT2 platform was used to compare HLA-B27 expression levels in different human tumors, and gene-gene interaction network was generated using GeneMANIA to identify correlation of HLA-B27 with other human genes. The qPCR analysis demonstrated an increase in the HLA-B27 expression by 1.65 fold in RA compared to normal control. ROC analysis indicated that HLA-B27 expression could efficiently differentiate RA from normal, supporting its potential use as diagnostic molecular biomarkers. The GENT2 revealed that HLA-B27 expression levels vary across different tumor types, most notably in heart tissue. The gene-gene interaction network revealed that KIR3DL1, KIR3DS1, LILRB1, B2M and LILRA1 were the leading genes showing the highest correlations with the HLA-B27. Our results indicate that HLA-B27 gene is involved in the RA pathogenesis and it can be used as a molecular biomarker for the diagnosis of RA. Our findings could lead to the discovery of novel diagnostic, preventive and therapeutic strategies.
territorial de las problemáticas socio-ambientales y habitacionales
Authors: Bianchini Natalia 
Published: September 2023

El propósito del presente artículo es analizar la vinculación entre lo territorial en las problemáticas socio-ambientales y habitacionales actuales. Para ello, se parte de la configuración de la cuestión social para comprender cómo se instala la división social, sexual y racial del trabajo, la distribución del poder a escala global y su vinculación con las políticas neoliberales de los gobiernos latinoamericanos. Luego, se reconstruyen ciertos aspectos socio-históricos de la conformación de las villas miserias y abordan las expresiones de las problemáticas ambientales y habitacionales en los territorios objeto de estudio. Por último, se reflexiona sobre la vinculación entre lo territorial y los procesos de salud, enfermedad, atención y cuidados.
Centros Educativos Complementarios, instituciones puente en tiempos de crisis
Authors: Herrera María Laura 
Published: September 2023

La pandemia del COVID-19, ante la suspensión de las clases presenciales, ha generado efectos colaterales en las trayectorias educativas de les niñes y adolescentes, conllevando a un despliegue de estrategias profesionales en las instituciones de enseñanza. El presente artículo se centra en el trabajo realizado en los Centros Educativos Complementarios 801, de Berisso, y 802 de Ensenada, durante y posteriormente a la pandemia, a modo de reflexionar en torno a lo significan estas instituciones para las comunidades barriales, y las transformaciones que generó la crisis socio-sanitaria en la política educativa, en las dinámicas familiares y en el ejercicio profesional, en particular en los Equipos de Orientación Escolar.
bosquecito de Hernández
Authors: Henao Tapasco Julián Eduardo 
Published: September 2023

Un territorio urbano, conocido como el bosquecito de Hernández, se presenta como objeto de observación y análisis, pues en su interior se desatan conflictos de representación y entre representaciones, que vinculan su propiedad, posesión, uso y destinación, y que abarcan prácticas sociales, jurídicas y políticas ejercidas por los participantes en el juego de interés, que van desde el cuidado y modificación del territorio con fines de habitación (familias ocupantes), la ejecución de proyectos de permacultura y agroecología (Asociación civil El Bosquecito/ vivero experimental), hasta la activación de procesos policiales y judiciales relacionados con la propiedad privada y la defensa del territorio (Familia Larrán/Organización civil) y la investigación de posibles violaciones a derechos humanos y la responsabilidad empresarial sobre los mismos (aparatos de Estado en materia de juicio y memoria). Para comprender las dinámicas de apropiación y uso de dicho territorio, en este trabajo se retoman las categorías analíticas sociológicas de "palimpsesto territorial” y “memoria urbana”.
Indicators of surgical stress and influence of clinical experience, simulation models, and cadaveric laboratory on the stress response of third-year veterinary students performing first elective surgery
Authors: Erickson Andrea K. , Carson Brittney A. , Selmic Laura E. , Bednarski Linda S. , McLoughlin Mary A. 
Published: September 2023

Abstract

OBJECTIVE
To evaluate the role of simulation models and previous surgical experience on subjective and objective stress levels of students performing their 1st elective surgery within the veterinary curriculum.

SAMPLE
141 third-year veterinary students

METHODS
Using a pre–post experimental design, salivary alpha-amylase, and cortisol were evaluated as markers of physiologic stress response before students’ first elective surgery. Student self-reported State-Trait Anxiety Inventory (STAI) scores and quantitative measures of experience were correlated to biomarker results.

RESULTS
No association was found for change in salivary biomarkers of stress, alpha-amylase, and cortisol, between baseline and presurgical samples accounting for gender, age, type of elective surgery performed, previous surgical experience, or simulation model use. Salivary cortisol levels were markedly elevated falling between the 66th and 99th percentile compared to an age and gender-matched population. Salivary alpha-amylase levels were also 2 to 3 times higher than those recorded by other health professionals. Veterinary student STAI scores were high falling between the 65th and 73rd percentile compared to working adults in the general population.

CLINICAL RELEVANCE
Veterinary students’ salivary cortisol, alpha-amylase, and STAI scores fell into the upper 2/3rds of the general population, demonstrating a high level of stress. Simulation models and previous surgical experience were not associated with decreased stress. Further evaluation of the implementation of high-fidelity simulation models and the role of stress on performance is indicated.
Synthesis, antioxidant activity, and HPLC enantioseparation of aryloxyaminopropanols derived from naphthalen-2-ol
Authors: Čižmáriková R. , Habala L. , Valentová J. , Némethy A. , Bruchatá K , Hroboňová K. 
Published: September 2023

Abstract
The present work describes the synthesis, physico-chemical characteristics, antioxidative properties, and high-performance liquid chromatography (HPLC) enantioseparation of novel, potentially bioactive aryloxyaminopropanols – derivatives of naphthalen-2-ol modified in the basic part of their molecules. Reaction of naphthalene-2-ol with chloromethyloxirane leads to 2-[(naphthalen-2-yloxy)methyl]oxirane, which reacts in the next step with branched aliphatic amines (isopropylamine, tert-butylamine, and dimethylamine), aromatic amines (aniline, 3,4-dimethoxyphenylethylamine), and heterocyclic amines (pyrrolidine, imidazole, 2-methylimidazole, piperidine, morpholine, 4-methylpiperidine, or 2-methoxyphenylpiperidine). The target compounds were isolated in the form of free bases, as well as their salts with fumaric or hydrochloric acid. Their purity was established by thin-layer chromatography and their IR, UV, 1H-NMR, and 13C-NMR spectra were recorded. The antioxidant activities of prepared compounds were measured by the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) method and they were compared with the values for the corresponding salts. Enantioseparation was accomplished by means of enantioselective HPLC using amylose tris(3,5-dimethylphenyl)carbamate (Chiralpak AD), as well as Chirobiotic T (native teicoplanin) in some cases.
The condition of periodontal tissues and selected microorganisms presence around implants and natural teeth
Authors: Jaszczak-Małkowska Magdalena , Grabowska Ewa , Górski Bartłomiej , Górska Renata 
Published: September 2023

Abstract

Introduction
Periodontitis is a disease of the tissues surrounding the tooth, leading to tooth loss. Missing teeth are often restored with fixed prostheses supported by implants. The aim of this study was to analyze subgingival microbiota in periodontal pockets and around implants, as well as to assess the correlation of periodontal parameters and risk factors for periodontitis with the presence of selected bacteria.

Materials and Methods
The study included 33 patients of both sexes, aged 39 to 79 years, having their own dentition and intraosseous implants with healthy periodontium or reversible gingivitis. The patients underwent periodontal examination and bacteriological analysis with the use of a PET RT-PCR kit (MIP Pharma, Germany).

Results
Less plaque was observed on implant surfaces than around natural teeth (28.7% vs. 39.8%). On the other hand, significantly deeper pockets (2.9 vs. 2.3 mm), and a slightly higher gingival bleeding index (27.9 vs. 22.6%) were noted around implants.

Conclusions
There were no significant differences in the overall presence and number of studied pathogens between the natural teeth and implants. In the case of natural teeth, the presence of Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia and Prevotella intermedia showed correlation with clinical status: the amount of plaque (Td, Tf), bleeding (Td, Tf, Pi) and probing depth (Pg, Td, Tf, Pi). Such relationships were not observed in the case of implants. Bacteria from periodontal pockets also demonstrated more correlation with the general condition compared to bacteria residing in tissues around implants.
Building Self-Confidence by Using a Sports Bra as an Everyday Bra - a Study Based on Pressure Analysis
Authors: Ocran Francisca Margarita , Xiaofen JI , Zhai Lina 
Published: September 2023

Abstract
Women often use sports bras when doing physical activities, but most women have recently shown interest in using sports bras as everyday bras. Therefore, this study used pressure analysis to identify a suitable sports bra that generates less pressure at the shoulder strap for all breast sizes. Among fashion design and engineering students, an interview was conducted at Zhejiang Sci-Tech University. Based on this random survey, women found more comfort in using sports bras as everyday bras, but the shoulder strap and waistband prevented them from doing it regularly. Therefore, this study emphasized only the shoulder straps because it was the most uncomfortable feature among others. More attention needs to be made to the strap width and neckline when selecting a sports bra because when it comes to females with breast sizes 34C and 36C, encapsulation types with cross-back designs are suitable. However, we noticed that the shoulder straps should be widened based on breast size. The encapsulation type with a racer back is recommended for women with breast size 38C.
TUCBS Veri standartları kullanılarak su kaynakları yönetimi değerlendirmesi
Authors: BİNGÜL Bilge , BENGİ Elvan , TUTKAL Zeynep , ALTUNSOY Alper , AKSOY Talha 
Published: September 2023

Su, canlılar için vazgeçilmez bir kaynaktır ve doğada sınırlı miktarda bulunmaktadır. Son yıllardaki hızlı nüfus artışına paralel olarak gelişen sanayi ve tarımsal faaliyetlerle birlikte su kaynaklarının aşırı kullanımı da artmıştır. Buna ek olarak, küresel iklim değişikliğinin, kuraklığın artmasına ve yüzey suları ile yeraltısularının beslenmesinde azalmaya yol açtığı gözlemlenmektedir. Tatlı suyun sınırlı olması, gerektiğinde yeterli miktarda tahsis edilememesi ya da taşkın ve sel gibi durumlarda fazla suyla karşılaşılması, su kaynaklarının doğru yönetiminin ne kadar önemli olduğunu açıkça ortaya koymaktadır. Bir ülkedeki su güvenliği, su kaynaklarının verimli kullanımı ve sürdürülebilirliğiyle doğrudan ilişkilidir. Bu araştırmada, su kaynakları yönetiminde önemli olan üç inceleme başlığı belirlenmiştir: yağış-akış ilişkisi analizleri, taşkın analizleri ve hidrojeolojik analizler. Araştırmanın amacı, bu analizlerde yaygın olarak kullanılan yöntemlerin belirlenmesi, temel coğrafi verilerin beklenen zamansal çözünürlüklerinin tespit edilmesi, ayrıca bu verilerin Türkiye Ulusal Coğrafi Bilgi Sistemi (TUCBS) veri standartlarına uygunluğunun araştırılmasıdır. Çalışma sonucunda, TUCBS veri standartlarının su kaynakları yönetiminde kullanılan birçok temel veri standardını karşıladığı, ancak zamansal çözünürlük bilgisinin standartlar içerisinde yer almadığı tespit edilmiştir. Bu çalışma, su kaynakları yönetiminde veri standartlarının geliştirilmesi ve yaygınlaştırılması için önemli bir adım atmayı hedefleyerek, sürdürülebilir su kaynakları yönetimi alanında önemli bir katkı sağlamayı amaçlamaktadır.
Bir ülkedeki su güvenliği, su kaynaklarının verimli kullanımı ve sürdürülebilirliğiyle doğrudan ilişkilidir. Bu araştırmada, su kaynakları yönetiminde önemli olan üç inceleme başlığı belirlenmiştir: yağış-akış ilişkisi analizleri, taşkın analizleri ve hidrojeolojik analizler. Araştırmanın amacı, bu analizlerde yaygın olarak kullanılan yöntemlerin belirlenmesi, temel coğrafi verilerin beklenen zamansal çözünürlüklerinin tespit edilmesi, ayrıca bu verilerin Türkiye Ulusal Coğrafi Bilgi Sistemi (TUCBS) veri standartlarına uygunluğunun araştırılmasıdır.

Çalışma sonucunda, TUCBS veri standartlarının su kaynakları yönetiminde kullanılan birçok temel veri standardını karşıladığı, ancak zamansal çözünürlük bilgisinin standartlar içerisinde yer almadığı tespit edilmiştir. Bu çalışma, su kaynakları yönetiminde veri standartlarının geliştirilmesi ve yaygınlaştırılması için önemli bir adım atmayı hedefleyerek, sürdürülebilir su kaynakları yönetimi alanında önemli bir katkı sağlamayı amaçlamaktadır.
HOW THE SPEECH-LANGUAGE PATHOLOGIST INTERACTS WITH CYSTIC FIBROSIS PATIENTS? A SCOPING REVIEW
Authors: Corrêa Camila de Castro , Rodrigues Kálita Kayne , Vieira Andressa Lopes , Dias Amanda Zuqui , Weber Silke Anna Theresa , Padovani Leticia Faccin , Foppa Maria Carolina Ceron , Maximino Luciana Paula , José Maria Renata 
Published: September 2023

Objective: The review describes the changes related to sleep-breathing disorders, communication and feeding processes in subjects with CF, through a scoping review. Methods: A scoping review based on the PRISMA protocol was carried out in Pubmed, Lilacs and Scopus databases, to investigate the possibility of including SLP in the treatment of patients with CF. The inclusion criteria included studies that addressed communication and eating processes and disorders related to CF. Studies with a sample that presented other comorbidities that would justify the worsening of the condition, or secondary studies, were excluded. There was no time or language delimitation. Results: The search found 1566 works, 27 Lilacs, 1009 Pubmed and 530 Scopus, by analysis of titles, abstract and reading in full. A total of 30 articles were selected for inclusion, 2 Lilacs, 22 Pubmed and 6 Scopus, all related to Speech-Language Pathology. Conclusion: It was observed that there is a poor sleep quality due to nocturnal desaturation, mild and moderate obstructive apnea. In studies related to hearing, individuals had sensorineural hearing loss. Speech-Language Pathology is of paramount importance in monitoring these subjects.
Communication Patterns on Addicted Elementary School-Age Children in Playing Free Fire Games
Authors: Saputra Muhammad Obby 
Published: September 2023

Free fire online game is an online game that is currently popular with elementary school age children. This game, which is currently being played by children, has been downloaded more than one million times. This game is a battleground game. Lots of children have been given personal gadgets by their parents. This makes elementary school-aged children lose track of time and tend to be addicted to free fire online games. In addition, since the pandemic, regulations have been implemented for all citizens not to leave their homes to control the spread of the Covid-19 virus. However, because of this, many children are used to using gadgets and are addicted to online games, especially free fire online games. The role of parents is needed in the condition of children who are addicted to free fire online games. Therefore, researchers want to see how communication patterns occur in families in children who are addicted to playing free fire games. Researchers conducted research in North Sangatta District, East Kutai Regency, East Kalimantan because researchers saw many elementary school-age children who had been given personal gadgets by their parents and played free fire online games. This study uses the constructivism paradigm. This study used descriptive qualitative method. There were 4 key informants in this study consisting of 2 parents and 2 children. As for the supporting informants, namely 1 child's playmate and 1 older sibling, and one expert informant who is a family psychologist. Data collection techniques used in the form of observation and in-depth interviews. To increase the validity of the data, researchers used the triangulation method, namely comparing the results between observations and in-depth interviews obtained. In this study, there are two types of family communication patterns, namely protective communication patterns and pluralistic communication patterns. In this study it was found that the liveliness of communicating with children every day is not enough to eliminate online game addiction in children. Parents should be more aware of their children. Care is needed, as well as an understanding of parenting for children.
Keywords: Communication Pattern, Online Game, Free Fire, Children
Burnout in Healthcare Staff due to COVID Pandemic in a Tertiary Care Dedicated COVID Hospital
Authors: Guroo Abrar M. , Suhaff Ajaz Ahmad , Teli Bilal Ahmad , Majid Abdul 
Published: September 2023

Objectives
To evaluate the socio-demographic profile and burnout among frontline doctors, paramedical, and other supporting staff in dedicated tertiary COVID hospitals.

Materials and Methods
The samples taken were divided into three groups as follows: Doctors, paramedical staff, and other supporting staff working in a tertiary hospital dedicated to handling the COVID-19 pandemic at SKIMS-MCH Bemina Hospital.

Results
In this study, a total of 185 participants took part out of which 388 individuals were employed across the medical departments of this hospital. This was an overall response rate of 47.6%. Most participants were in the age group of 31–50 years (48.6%). Males comprised 53.5%, married 66.4%, living with family 82.7%, and as per job description, most responses were from paramedical staff (53.51%). On analysis of the mean ± SD score of burnout across individual socio-demographic variables predominant burnout was seen in paramedical staff (45 ± 5.2) followed by those living with family (42 ± 3.7), married (43 ± 1.2), and those older than 50 years (40 ± 3.9).

Conclusion
Our study showed that the high prevalence of burnout was among healthcare professionals in the tertiary hospital who were exposed to working and catering large population with serious healthcare and emergency issues caring for patients during the new pandemic. Factors such as female gender, living with family, and older age of healthcare professionals were associated with significant burnout. These findings can help to improve the preparedness for the future.
Microsurgical and endoscopic-assisted supraorbital keyhole approach for intra-suprasellar cysticercosis
Authors: Burgos-Sosa Erik , Bergna-Vazquez Patricia , Mendizabal-Guerra Rafael , Ayala-Arcipreste Arturo 
Published: September 2023

Background:
Treatment for intra/suprasellar cysticercosis can be challenging and may result in visual disturbances if not managed properly. Despite its limited knowledge, an effective surgical option exists to treat this condition. This article presents three cases of sellar cysticercosis, comprising one female and two male patients, managed with microsurgical supraorbital keyhole approach (mSKA) and endoscopic-assisted supraorbital keyhole approach (eaSKA).

Case Description:
The first patient is a 35-year-old man with no prior medical history who suffered from memory deficits and visual disturbances due to a sellar cyst pushing the orbitofrontal gyrus treated with mSKA. The second case involved a 52-year-old man who experienced visual deficits caused by a rostral sellar cyst with posterior displacement of the pituitary gland treated with eaSKA. The third case was a 46-year-old woman who experienced decreased visual acuity and memory loss due to multifocal neurocysticercosis (NCC) with sellarsuprasellar cyst extension treated with mSKA. All case diagnoses were confirmed by neuropathology department.

Conclusion:
The authors confidently suggest that the SKA is an effective surgical option and could be considered for removing sellar cystic lesions with suprasellar extension. With endoscopic assistance, it improves adequate neurovascular structure visualization.
TECHNOLOGIES FOR LEACHING OF NON-FERROUS METALS FROM ORES
Authors: Очеретяна С.О. 
Published: September 2023

Первичные сульфиды составляют большую часть мировых запасов различных цветных металлов, которые обрабатывают методами плавки и рафинирования. Выщелачивание цветных металлов из этих руд является трудной задачей. В основном, разработанные технологии основываются на химическом выщелачивании. В статье рассматривается текущее состояние технологических решений в области выщелачивания цветных металлов с учетом совмещения технологий при выщелачивании металлов из руд и отвалов. Показаны новые введения позволяющие получить более продуктивный эффект в процессе выщелачивания.
Primary sulfides make up the majority of the world’s reserves of various non-ferrous metals, which are processed by smelting and refining methods. Leaching base metals from these ores is a difficult task. The developed technologies are mainly based on chemical leaching. The article considers the current state of technological solutions in the field of leaching of non-ferrous metals taking into account the combination of technologies for leaching of metals from ores and dumps. New introductions allowing to get more productive effect in the leaching process are shown.