bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peculiarities of determining the morphogenesis of plants Corylus avellana L. and Prunus dulcis (Mill.) D.A.Webb in vitro culture
Authors: Matskevych Vyacheslav , Yukhnovskyi Vasyl , Kimeichuk Ivan , Matskevych Oksana , Shyta Oksana 
Published: March 2023

ABSTRACT
The purpose of the research was to identify the physiological–biochemical and anatomical–morphological peculiarities found during in vitro cultivation of Corylus avellana L. and Prunus dulcis (Mill.) D.A.Webb, which occur as a result of the action of trophic and phytohormonal determinants. The research was conducted on three hazelnut varieties (Trapezund, Jefferson, Tonda Gentile Romana) and four almond varieties (E5 Borozan, M41 Alex, Georgia, Louise). A theoretical and experimental rationale for their use in the microclonal propagation of these cultures has been developed. The effectiveness of the preparatory stage before introduction into aseptic conditions for growing mother plants in closed soil conditions with scattered artificial lighting and microbiological protection has been proven. This reduced self-intoxication by oxidation products with phenol-like substances and microflora contamination of primary explants. Among the nutrient media compared, the best was Nas and Read (NRM) for hazelnuts and Nas Almond Medium (NAM) for almonds. Passaging on the same media leads to a decrease in regeneration indicators. In regenerants of almonds, the rosette of the shoots was noted, and in hazelnuts, the death of apical buds was also found. To prevent this, alternating NRM and driver and kuniyuki walnut (DKW) media for hazelnuts and NAM and Quirin and Lepoivre (QL) for almonds was effective. Long-term cultivation on media with a high content of synthetic analogues of phytohormones leads to the accumulation of phytotoxic effects with each subsequent passage. The phytotoxic effect of cytokinins was manifested in hyperhydration of shoots and of auxins in callus fertilisation. On comparing the ontogenesis of regenerants from explants isolated from mother plants aged 30–180 days, it was found that the optimal age for hazelnut and almond was 90 days. To reset the trophic and hormonal determinants, the introduction of explant donors into a state of dormancy has been successfully used. At the final fourth stage of microclonal propagation, in order to adapt plants simultaneously with an increase in the number of regenerants, it is effective to use the photoautotrophic method of microclonal propagation with intensive lighting and air enriched with carbon dioxide. For the transition of plants from conventional heterotrophic propagation to autotrophic cultivation, an intermediate stage of pre-adaptation of regenerants in wet chamber conditions is effective.
Elaboration of the geotechnical map of ain temouchent-city (Algeria)
Authors: AMRAOUI Bénamar , HOUMADI Youcef , MAMOUNE Sidi Mohammed -AISSA 
Published: March 2023

Abstract
The region of Ain-Témouchent is a seismic zone; its land is predominately agricultural and shows complex structures, with many problems linked to the development of urbanized areas; these problems are directly or indirectly related to the geotechnical conditions of soil.
The purpose of the present research is to build a database from the different measurements carried out in the region, and to conduct tests in places where information is not available in order to consider the entire perimeter of the study area.
Once the database is completed, an analysis of all the data will be carried out using a numerical tool in order to establish the geotechnical map of the city. This map will certainly allow all decision-makers and designers to have clear and precise information when proposing or designing new structures.
The geotechnical mapping of Ain-Temouchent soils based on 178 observations divided these soils into ten groups. Eight of them according to the Unified Soil Classification System (USCS): CH (High plasticity clay), CL (Low plasticity clay), MH (High plasticity silt), ML (Low plasticity silt), SC (clayey sand), SM (Silty sand), GM (Silty gravel with sand), OH (organic soil of high plasticity). The other two groups are rocky soils: basalts (hard volcanic rock with high resistance), and limestone turf (sedimentary rock).
Influence of double cavities on anchors capacity
Authors: NAJI Ali , MUSTĂŢEA Florin-Sebastian 
Published: March 2023

Abstract
Soil is considered an essential component of the factors that are affecting the structures. Due to the problems that are faced under various conditions while the structure is in use, the behavior of the soil is complex. The presence of cavities inside various types of soil, such as gypsum soil and the soil of some old towns, is one of its difficult problems. The formation of these cavities is due to natural and industrial causes, one of the natural causes being the dissolve of salts inside them. As for the industrial one, it is due to the presence of some old buildings. The presence of this type of cavities affects the life of the structures and as a result, it creates cracks in the foundation, therefore reducing the life of the structures.
The unexpected formation of cavities inside the soil was based mainly on some practical experiments for this research. Two cavities have been created inside the soil with different locations from the anchor to study the capacity of the anchor. The results showed that the presence of the cavity affects the capacity of the anchor according to its location from the plate as well as from the rod. The closer the cavity are to the plate; the capacity have been decreased by a certain percentage depending on the distance from the plate anchor.
Abusive Constitutionalism in Hungary
Authors: Juhász Krisztina 
Published: March 2023

Abstract
The study, using the concept of abusive constitutionalism, examines those formal and informal constitutional changes which took place after the Fidesz-KDNP coalition had come into power in 2010 and resulted in the hybridisation of the Hungarian political system. The paper, using qualitative research methods such as analysis of the relevant literature and primary resources, including the in-depth analysis of the relevant Constitutional Court decisions, comes to the conclusion that the Orbán governments first dismantled the checks and balances, foremost the Constitutional Court via formal abusive constitutional changes, and as a next step, with the contribution of the weakened and packed Constitutional Court, the government aims to eliminate the EU’s legislation and intervention on the field of asylum policy via formal and informal abusive constitutional changes based on the concepts of constitutional pluralism and identity.
ПІДГОТОВКА ФАХІВЦІВ ДО ЗДІЙСНЕННЯ НЕПЕРЕРВНОЇ ЕКОНОМІЧНОЇ ОСВІТИ ДІТЕЙ, ЮНАЦТВА ТА ГОСПОДАРСЬКО-ЕКОНОМІЧНОГО ПРОСВІТНИЦТВА ДОРОСЛИХ У ЗАХІДНІЙ УКРАЇНІ (КІНЕЦЬ ХІХ – ПОЧАТОК 40-х рр. ХХ ст.)
Authors: Білавич Галина , Багрій Марія , Гречаник Наталія 
Published: March 2023

Стаття присвячена проблемі неперервної економічної освіти дітей, юнацтва, дорослих у Західній Україні, увиразнено історичний досвід практики підготовки фахівців до здійснення господарсько-економічного виховання учнів та дорослих наприкінці ХІХ – на початку 40-х рр. ХХ ст. Попри регіональну специфіку, зміст підготовки вчителів до керівництва процесом виховання господарсько-економічної культури особистості мав багато спільного в Галичині, Буковині й Закарпатті, особливо за часів панування Австро-Угорщини. За міжвоєнного періоду ХХ ст. у Польщі сформувалася складна система канікулярно-курсової підготовки та підвищення кваліфікації педагогічних кадрів. За доби Другої світової війни не вдалося налагодити системної підготовки фахівців до виховання господарсько-економічної культури учнів, за винятком території Генерального губернаторства.
Deucravacitinib in moderate to severe plaque psoriasis: liver transaminase results from the phase 3 POETYK PSO program
Authors: Lebwohl Mark , Egeberg Alexander , Linaberry Misti , Hoyt Kim , Banerjee Subhashis , Kisa Renata M. , Strober Bruce 
Published: March 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 (TYK2) inhibitor, is approved by the US Food and Drug Administration for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the phase 3 POETYK PSO-1 and PSO-2 trials, deucravacitinib treatment did not result in clinically meaningful changes across multiple laboratory parameters, including liver transaminases and bilirubin. The current analysis assessed changes in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in the pooled POETYK PSO-1 and PSO-2 population over 16 weeks.
Methods: In POETYK PSO-1 and PSO-2, patients with moderate to severe plaque psoriasis were randomized 1:2:1 to oral placebo, deucravacitinib 6 mg once daily, or apremilast 30 mg twice daily. Patients randomized to placebo crossed over to deucravacitinib at Week 16 in both trials. This analysis uses data from POETYK PSO-1 and PSO-2 pooled by treatment group from Weeks 0-16. ALT and AST were evaluated as mean levels over time, shifts from baseline in Common Terminology Criteria for Adverse Events (CTCAE version 5.0) severity grade, and fold-increase from upper limit of normal (ULN). Patient-level data were evaluated for those who experienced an elevation ≥3´ ULN for ALT or AST in the first 16 weeks of treatment.
Results: The pooled POETYK PSO-1 and PSO-2 population included placebo (n=419), deucravacitinib (n=842), and apremilast (n=422). ALT and AST results were available for 413, 833, and 419 patients, respectively. Mean levels of ALT and AST did not change over 16 weeks in any treatment arm. Shifts upwards ≥2 CTCAE grades from baseline in ALT and AST over Weeks 0-16 occurred at a low frequency overall; rates were comparable in patients treated with deucravacitinib (ALT, 0.4%; AST, 0.5%), apremilast (ALT, 0.5%; AST, 0.5%), and placebo (both ALT and AST, 0%). In addition, ALT and AST elevations ≥3´ ULN were infrequent (ALT: placebo 1.2%, deucravacitinib 1.1%, apremilast 0.5%; AST: placebo 0.5%, deucravacitinib 1.6%, apremilast 0.7%). Almost all ALT or AST elevations ≥3´ the ULN between baseline and Week 16 were transient and/or could be traced to underlying liver conditions or concomitant medications.
Conclusion: Treatment with deucravacitinib, apremilast, or placebo led to increases in ALT or AST levels from baseline over 16 weeks in a few patients; the increases that did occur were potentially related to underlying liver dysfunction, alcohol use, or use of concomitant medications.
Deucravacitinib long-term efficacy with continuous treatment in plaque psoriasis: 2-year results from the phase 3 POETYK PSO program
Authors: Lebwohl Mark , Warren Richard B. , Sofen Howard , Imafuku Shinichi , Paul Carle , Szepietowski Jacek C. , Spelman Lynda , Passeron Thierry , Colston Elizabeth , Hippeli Lauren , Napoli Andrew , Kisa Renata M. , Banerjee Subhashis , Menter Alan , Thaçi Diamant , Blauvelt Andrew 
Published: March 2023

Introduction: Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved by the US Food and Drug Administration for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. In the pivotal phase 3 POETYK PSO-1 trial, deucravacitinib was superior to placebo and apremilast using multiple clinical endpoints, including PASI 75 and sPGA score of 0 or 1 (clear/almost clear skin) at Week 16. Clinical efficacy was maintained through Week 52 on continued treatment. We examined long-term clinical efficacy in patients randomized to deucravacitinib on Day 1 in PSO-1 who opted to continue treatment at Week 52 in the long-term extension (LTE) trial.
Methods: In the 52-week POETYK PSO-1 trial, adult patients were randomized 2:1:1 to deucravacitinib 6 mg once daily, placebo, or apremilast 30 mg twice daily; upon trial completion, patients could enter the LTE and receive deucravacitinib. Efficacy endpoints included PASI 75, PASI 90, and sPGA 0/1. Maintenance of response was assessed in Week 16 PASI 75 responders continuing treatment in the LTE. Modified nonresponder imputation (mNRI) was used to impute missing data; patients discontinuing due to psoriasis worsening were imputed as nonresponders. Efficacy results used as-observed data and treatment failure rule imputation.
Results: Of 332 patients randomized to deucravacitinib in PSO-1, 265 completed the trial and entered the LTE, including 173 Week 16 PASI 75 responders. The mNRI population included 262 deucravacitinib patients entering the LTE, including 171 Week 16 PASI 75 responders; patients failing to reach the Week 112 assessment or discontinuing as of October 1, 2021, were excluded. At Week 112 (LTE Week 60), mNRI response rates among deucravacitinib patients entering the LTE were 82.4% (PASI 75), 55.2% (PASI 90), and 66.5% (sPGA 0/1). Efficacy was maintained up to 112 weeks in Week 16 PASI 75 responders continuing treatment, including PASI 75 response rates at Weeks 16, 52, and 112 (100%, 90.1%, 91.0%, respectively), PASI 90 (62.6%, 64.9%, 63.0%), and sPGA 0/1 (84.2%, 73.7%, 73.5%).
Conclusion: Clinical efficacy was maintained up to 112 weeks with continuous treatment, further supporting deucravacitinib as an effective treatment for patients with moderate to severe plaque psoriasis.
Investigator global assessment (IGA) of Acne Vulgaris and IGA Success among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S in PROSES study: Analysis by concomitant medication
Authors: Baldwin Hilary , Del Rosso James , Kircik Leon , Stein Gold Linda , Hebert Adelaide , Rieder Evan , Alexis Andrew , Harper Julie , Fried Richard , Narayanan Siva , Koscielny Volker , Kasujee Ismail , Graber Emmy 
Published: March 2023

Introduction: The objective of this analysis was to evaluate facial IGA and the associated IGA success, stratified by the use of concomitant acne medications, among AV patients administered sarecycline in community practices across the U.S.
Methods: A single-arm, prospective cohort study (PROSES) was conducted with moderate-to-severe non-nodular AV patients >9 years who were prescribed sarecycline in real-world community practices in the US. Facial IGA of AV status was collected on a five-point adjectival response scale (0(clear)-4(severe)). IGA success at week-12 was defined as >2-grade improvement and score 0-clear or 1-almost clear at week-12. Proportion of patients achieving IGA success was analyzed, stratified by the use of any concomitant AV medication during the study (Yes vs. No (monotherapy)).
Results: A total of 253 AV patients completed the study (adults 60.08% (mean age 26.63); pediatric 39.92% (mean age 14.81); female: 66.40%; white/caucasian: 68.38%, african-american: 8.70%; other races: 22.92%). Per IGA at baseline, 86.56% & 13.44% had moderate and severe AV, respectively. Key concomitant treatments for AV observed during the study included: topical retinoids (24.51%), topical antibiotics (13.44%), benzoyl peroxide (5.93%), topical dapsone (5.14%) and other (17.00%; predominantly adapalene/benzoyl peroxide). Half of the patients (49.80%) were on sarecycline monotherapy (i.e., did not use any concomitant treatments for AV). For the overall study cohort, IGA success at week-12 was 58.89%. At week-12, IGA success was 59.84% among patients using concomitant AV medications, and 57.94% among patients using no concomitant AV medications (i.e., on sarecycline monotherapy).
Conclusion: Within the study cohort administered sarecycline, a narrow-spectrum, tetracycline-derived antibiotic, for 12 weeks, majority of patients achieved IGA success at week-12, and the outcomes were similar among patients on sarecycline monotherapy and those on concomitant AV medications.
Genomic Profiling of Lentigo Maligna within an Interim Registry Analysis​
Authors: Stevens Greg , Rock James , Jansen Burkhard , Arnold Terry , Wood Jennifer , Clarke Loren , Hyde Mark 
Published: March 2023

Background: Pigmented lesion analysis remains a challenging aspect of dermatology. The DermTech Melanoma Test (‘the test’) is a non-invasive genomic test designed to rule-out melanoma. It consists of the pigmented lesion assay, which detects RNA products of Long Intergenic Non-Coding RNA 00518 (LINC00518) and Preferentially Expressed Antigen in Melanoma (PRAME), and an add-on assay for DNA promoter mutations in telomerase reverse transcriptase (TERT). In previous studies, the test was found to have a negative predictive value ≥99%. This interim analysis of a registry study examines the genomic patterns of the Lentigo Maligna (LM) subtype of melanoma.
Methods: Between April 2021 and March 2022, multiple geographically diverse sites throughout the US submitted data to a registry to assess real-world use of the test. Approximately 8,000 clinically atypical lesions were tested. After receiving the test result, providers followed their clinical judgement for biopsy decision. Histopathologic diagnoses for biopsied lesions were correlated with test results and all melanomas were sorted into LM subtype vs non-LM subtype. In addition, lesions that were noted to be on sun exposed skin and/or noted to have solar elastosis and called atypical melanocytic hyperplasia were included.
Results: At the 1-year mark of the registry, there were roughly 8000 unique entries. Of those, 1003 expressed one or more genomic markers from the DMT and had records available, and 134 (13.2%) were found to be melanoma or melanoma in-situ. More than a third (n=46, 34.3%) of the melanomas were of the Lentigo Maligna sub-type, with 7 of those being Lentigo Maligna Melanoma (LMM). Seven additional lesions were called atypical junctional melanocytic hyperplasia (AJMH) on sun-damaged skin. This group of 53 LM, LMM, and AJMH lesions were all evaluated for correlations to the DMT markers. LINC was the most commonly expressed genomic marker (n=45, 84.9%), with PRAME (n=36, 67.9%) and TERT (n=24, 45.3%) following. Most invasive tumors (LMM) expressed all three markers (n=4) and all 7 expressed LINC.
Conclusion: While the original validation study included the LM subtype, this interim registry analysis demonstrates real-world use of the DMT in assessing pigmented macules concerning for LM. Over 1/3 of the melanomas reported in the registry were LM subtypes. LINC had a higher correlation with the lentigo maligna subtype of melanoma and was present in all invasive tumors. While AJMH is considered borderline, it may be worthwhile in the clinical context to group AJMH lesions with LM due to similarities in treatment.
Non-Invasive Genomic Profiling in Pediatric Patients
Authors: Perry Allyson , Ruppenthal Danielle , Hill Kellie 
Published: March 2023

Background:Pigmented lesions with clinical features suspicious for melanoma are not uncommon in pediatric patients. Evaluation of these lesions is complicated by the low prevalence of pediatric melanoma and challenges associated with performing biopsies in children. The DermTech Melanoma Test (‘the test’) is a non-invasive genomic test designed to rule out melanoma. It consists of the Pigmented Lesion Assay (PLA), which detects RNA gene expression of long intergenic non-coding RNA 00518 (LINC00518, or LINC) and preferentially expressed antigen in melanoma (PRAME), and an add-on assay for DNA promoter mutations in telomerase reverse transcriptase (TERT), which is performed if ordered and if sufficient genomic material is available. Patients younger than 18 years were not included in initial validation studies. In this analysis, we sought to compare genomic biomarker results between uncertain pigmented lesions from adult and pediatric patients.
Methods:De-identified samples submitted to the clinical lab for the test from May through October 2022 were used for this analysis. Genomic results were available for 36,377 samples. The anatomic locations of the lesions were categorized as head/neck, trunk, or extremities and compared between adult and pediatric patients. Positivity rates for the PLA (and each individual marker) and the TERT add-on assay were calculated for adults and patients younger than 18 years of age.
Results:The PLA was performed on 34,050 skin samples from adults and 2,327 samples from pediatric patients. There were no differences between adults and pediatric patients in anatomic location of the lesions tested. The proportion of PLA-positive samples was similar between adult (7.0%, n=2,393) and pediatric (8.0%, n=187) patients. Rates of biomarkers detected among PLA-positive adult and pediatric patient samples, respectively, were as follows: LINC only (31.4% vs 69.5%), PRAME only (45.5% vs 14.4%), LINC and PRAME (23.0% vs 16.0%). The TERT add-on assay was performed in 11,084 samples from adults and 613 samples from pediatric patients. Of these, TERT was positive in 830 (7.5%) adult and 3 (0.5%) pediatric patient samples.
Conclusions:This analysis provides new information about genomic profiling of uncertain pigmented lesions from pediatric patients. While overall PLA positivity rates were similar across adult and pediatric samples, the proportion positive only for LINC was more than two times higher in pediatric samples. Additionally, TERT promoter mutations were rarely detected in pediatric samples. Further investigation of the significance of LINC, PRAME, and TERT abnormalities in lesions from pediatric patients is ongoing.
NUMERICAL CALCULATION OF THE EFFECTIVE COEFFICIENT IN THE PROBLEM OF LINEAR ELASTICITY OF A COMPOSITE MATERIAL
Authors: Захаров П.Е. , Сивцев П.В. 
Published: March 2023

Рассмотрен численный расчет эффективного коэффициента задачи линейной упругости композитного материала на отдельном представительном элементе, имеющем аналогичную объемную долю фибр. Полученный эффективный коэффициент используются для решения полной задачи на грубой сетке. В качестве примера рассматривается задача расчета деформации бетонного блока с включением стальных фибр под действием трехточечного изгиба. Вычислительная реализация задачи проводится методом конечных элементов с использованием вычислительной платформы FEniCS.
We consider the numerical calculation of the effective coefficient of the linear elasticity problem on a representative volume element having a similar volume fraction of fibers. The obtained effective coefficient is used to solve the complete problem on a coarse grid. As an example, the problem of calculating the deformation of a concrete block with the inclusion of steel fibers under the action of a three-point bending is considered. The computational implementation of the problem is carried out by the finite element method using the FEniCS computing platform.
NUMERICAL METHOD FOR SOLVING BOUNDARY INVERSE PROBLEM FOR ONE–DIMENSIONAL PARABOLIC EQUATION
Authors: Vasil’ev V.I. , Ling-De Su. 
Published: March 2023

We consider a numerical method for solving boundary inverse problem using the implicit difference scheme for approximation by time and finite difference method for the boundary inverse problem. A numerical solution to the boundary inverse problem is determined by special decomposition which transforms the problem into two standard problems. We present the results of numerical experiments, including those with random errors in the input data, which confirm the capabilities of the proposed computational algorithms for solving this boundary inverse problem.