bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Patients with Active Cancers and Pre-Existing Cardiovascular Diseases Infected with SARS-CoV-2
Authors: Patel Brijesh , Chapman Scott , Neumann Jake , Visaria Aayush , Ogungbe Oluwabunmi , Wen Sijin , Khodaverdi Maryam , Makwana Priyal , Singh Jasvinder A. , Sokos George 
Published: May 2023

Abstract
Objective
To determine the impact of acute SARS-CoV-2 infection on patient with concomitant active cancer and CVD.
Methods
The researchers extracted and analyzed data from the National COVID Cohort Collaborative (N3C) database between January 1, 2020, and July 22, 2022. They included only patients with acute SARS-CoV-2 infection, defined as a positive test by PCR 21 days before and 5 days after the day of index hospitalization. Active cancers were defined as last cancer drug administered within 30 days of index admission. The “Cardioonc” group consisted of patients with CVD and active cancers. The cohort was divided into four groups: (1) CVD (-), (2) CVD (+), (3) Cardioonc (-), and (4) Cardioonc (+), where (-) or (+) denotes acute SARS-CoV-2 infection status. The primary outcome of the study was major adverse cardiovascular events (MACE), including acute stroke, acute heart failure, myocardial infarction, or all-cause mortality. The researchers analyzed the outcomes by different phases of the pandemic and performed competing-risk analysis for other MACE components and death as a competing event.
Results
The study analyzed 418,306 patients, of which 74%, 10%, 15.7%, and 0.3% had CVD (-), CVD (+), Cardioonc (-), and Cardioonc (+), respectively. The Cardioonc (+) group had the highest MACE events in all four phases of the pandemic. Compared to CVD (-), the Cardioonc (+) group had an odds ratio of 1.66 for MACE. However, during the Omicron era, there was a statistically significant increased risk for MACE in the Cardioonc (+) group compared to CVD (-). Competing risk analysis showed that all-cause mortality was significantly higher in the Cardioonc (+) group and limited other MACE events from occurring. When the researchers identified specific cancer types, patients with colon cancer had higher MACE.
Conclusion
In conclusion, the study found that patients with both CVD and active cancer suffered relatively worse outcomes when they had acute SARS-CoV-2 infection during early and alpha surges in the United States. These findings highlight the need for improved management strategies and further research to better understand the impact of the virus on vulnerable populations during the COVID-19 pandemic.
Evaluation Index System of Shenzhen Health-Promoting Schools in China based on the SPO Model
Authors: Gu Jiaming , Wu Sheng , Zhang Dan 
Published: May 2023

Abstract
Health-promoting schools is an important setting to publicize the concept, “Education and Health are an equal priority”, and it is an integral part of implementing the strategy of sanitation and health work jointly built and shared by the people. Based on the standards of Health-promoting schools management, this study constructed an index system of health-promoting schools in Shenzhen, China to meet the needs of management, evaluation, and development of Health-promoting schools in Shenzhen and promote the health of residents throughout the city by disseminating health concepts, knowledge, and skills to the students, their families, and their communities through the schools. By analyzing the existing literature on health-promoting schools and combining the characteristics of primary and secondary schools in Shenzhen, the index system was constructed in a preliminary way. After two rounds of the Delphi method to accept expert advice and using the analytic hierarchy process to calculate the weight of indicators at all levels in the evaluation system, the index system of Shenzhen Health-Promoting Schools was finally established. The authority coefficients of experts in the two rounds of consultation were 0.84 and 0.81, respectively, and the coefficients of concordance of experts’ importance of the index system were 0.24 and 0.25, respectively (P < 0.01). After the analytic hierarchy process test, the evaluation system consisting of 8 first-class indexes, 17 second-class indexes, and 64 third-class indexes of health-promoting schools in Shenzhen was finally determined. The system has a stable structure, coordinated expert advice, and a high degree of coherence.
Design, preparation and characterization of a high-performance epoxy adhesive with Poly (butylacrylate-block-styrene) Block Copolymer and Zirconia nano particles in aluminum- aluminum bonded joints
Authors: Varkani Mojtaba Nikkhah , Jazani Omid Moini , Sohrabian Majid , Esfahani Amir Torabpour , fallahi mohsen 
Published: May 2023

Abstract
Background
Epoxy adhesives are one of the polymers used as high performance matrix in adhesives. However, the high brittleness and low toughness due to their high-crosslinking degree are critical problems during their service in structural applications. The lack of appropriate thermal stability at high temperature is another drawback of these valuable materials. In this study, the effect of hybrid reinforcement comprising zirconium oxide nanoparticles (NPs), phenolic resin (resol type) and poly (butyl acrylate-block-styrene) copolymer (BCP) on mechanical, adhesion, thermal and morphological properties of the epoxy adhesive was studied.
Methods
Mechanical properties, thermal stability, and microstructure of the epoxy adhesive was assessed using tensile test, TGA, and FESEM tests, respectively. To investigate the adhesion features, the formulated adhesive was applied in lap joint bonding of an aluminum to aluminum.
Significant findings
A new approach was developed for designing advanced adhesives with high mechanical, adhesion and thermal properties by adding hybrid additives. Based on the tensile test results, adding 5 phr of zirconium oxide nanoparticles to the epoxy adhesive increased the tensile strength, modulus, and the toughness of the dumbbell-shaped samples by 69%, 33% and 175% as compared with the neat epoxy adhesive, respectively. Furthermore, the highest improvement of shear strength in the single lap joint was observed in the sample containing 10 phr phenolic resin, 5 phr zirconia NPs, and 2.5 phr block copolymer, showing a 420% increment compared to the pure epoxy, reflecting the synergistic impact of these compounds at the mentioned percentage. The TGA results indicated the highest initial degradation temperature in the sample containing 5 phr zirconia NPs which was 54.4oC higher than that of the pure epoxy. The images of the fracture surface of the optimal samples in the tensile test showed that the cavitation, shear band formation, crack deviation, and crack tip blunting are among the major mechanisms in the increase of the toughness of the samples.
Improving the adsorption capacity of graphene oxide. Effect of Ca2+ on tetracycline retention
Authors: Medina Florencia M. Onaga , Avena Marcelo J. , Parolo María E. 
Published: May 2023

Abstract

Tetracyclines (TCs) constitute a group of antibiotics that are commonly used to treat bacterial diseases, in veterinary medicine and as an additive in animal feed. This broad application has led to their accumulation in food products and the environment because sewage treatment plants cannot completely remove them. Therefore, the aim of this study was to synthesize graphene oxide (GO) and evaluate its TC adsorption properties in aqueous media. The effects of pH (between 2.5 and 11) and Ca2+ concentration (between 0 and 1M) were thoroughly investigated. Structural, textural, and electrokinetic properties of the prepared GO were determined by N2 adsorption/desorption, XRD, TEM, UV-vis, FTIR, XPS, thermogravimetry and electrophoretic mobility measurements. TC adsorption on GO is an interplay between the two main roles played by Ca2+: competitor or bridging cation. At low pH, there is cation exchange, and Ca2+ behaves as a competitor of the positively charged TC species, decreasing adsorption as calcium concentration increases. At high, the formation of Ca bridges between the surface and TC (GO-Ca2+-TC) is favored, increasing the adsorption of the antibiotic by increasing calcium concentration. Different combinations of Ca2+ and pH effects are important to improve the use of GO either as a pH-dependent and reversible TC adsorbent for decontamination or as pH-independent adsorbent for TC quantification with electrochemical sensors.
Does Sagittal Location of the Fracture Region of Vertebral Body Affect the Interfixation Instrument Biomechanics or Surgical Strategy in Thoracolumbar Fracture Treatment: a Finite Element Analysis
Authors: Cui Xilong , Zhu Junjun , Yang Wanmei , Sun Yuxiang , Huang Xiuling , Wang Xiumei , Yu Haiyang , Liang Chengmin , Hua Zikai 
Published: May 2023

Abstract
Background: Posterior internal fixation is the main method used for the treatment of thoracolumbar fractures. Fractures often occur in the upper 1/3 of the vertebral body. However, they can also occur in the middle or lower 1/3 of the vertebral body. At present, there is no report discussing the potential effects of sagittal location on instrument biomechanics or surgical strategy. The objects of this study was to investigate the effect of the sagittal location of the fracture region of the vertebral body on the biomechanics of the internal fixation system and surgical strategy.
Methods: A finite element model of the T11-L3 thoracolumbar segment was established based on a healthy person’s CT scan. Different sagittal fracture location finite element models were created by resection of the upper 1/3, middle 1/3, and lower 1/3 of the L1 vertebral body. Three surgical strategies were utilized in this study, namely proximal 1 level and distal 1 level (P1-D1), proximal 2 level and distal 1 level(P2-D1), and proximal 1 level and distal 2 levels (P1-D2). Nine fixation finite element models were created by combining fracture location and fixation strategies. Range of motion, von Mises stress, and stress distribution were analyzed to evaluate the effects on the instrument biomechanics and the selection of surgical strategy.
Results: In all three different fixation strategies, the maximum von Mises stress location on the screw did not change with the sagittal location of the fracture site; nevertheless, the maximum von Mises stress differed. The maximum rod stress was located at the fracture site, with its value and location changed slightly. In the same fixation strategy, a limited effect of sagittal location on the range of motion was observed. P2D1 resulted in a shorter range of motion and lower nail stress for all sagittal locations of the fracture compared with the other strategies; however, rod stress was similar between strategies.
Conclusions: The sagittal location of a fracture may affect the stress and distribution, but does not influence the selection of surgical strategy.
Transmission of drug-resistant Mycobacterium tuberculosis isolates between Finnish- and foreign-born patients, 2014-2021: a molecular epidemiological study
Authors: Zhu Jiahui , Haanpera Marjo , Mentula Silja , Vapalahti Olli , Soini Hanna , Sironen Tarja , Kant Ravi , Zakham Fathiah 
Published: May 2023

Abstract

BackgroundData on the molecular epidemiological characteristics and transmission of drug-resistantMycobacterium tuberculosis(MTB) isolates in low-incidence settings with immigration from high-incidence settings are limited.MethodWe included 101 drug-resistant MTB isolates with whole-genome sequencing data isolated in Finland between 2014 and 2021. Mutations associated with resistance to first- and second-line drugs were identified. Potential transmission clusters were identified using a threshold of 12 single-nucleotide polymorphisms (SNPs). Highly related clusters were identified using a threshold of 5 SNPs.ResultOf the 101 drug-resistant MTB isolates, 29 (28.7%) isolates were from Finnish-born persons and 72 (71.3%) were from foreign-born persons. The proportion of foreign-born persons with multidrug-resistant (MDR) MTB (25/72, 34.7%) was higher than that in Finnish-born persons (6/29, 20.7%). The most common mutation associated with resistance to INH and RIF was katG Ser315Thr (67/83, 80.7%) and rpoB Ser450Leu (29/35, 82.9%), respectively. Lineage 4 (36/101, 35.6%) and lineage 2 (35/101, 34.6%) were prevalent lineages. A total of 16 (15.8%) isolates were classified into 7 potential transmission clusters (≤ 12 SNPs). Furthermore, one highly related cluster (≤ 5 SNPs) was identified, including one MDR isolate from a Finnish-born person and another MDR isolate from a person born in eastern Europe.ConclusionTransmission of drug-resistant MTB isolates between native and foreign-born persons is limited in Finland. Monitoring transmission dynamics of drug-resistant TB is of importance to inform tuberculosis management and control in low-incidence settings with increasing immigration.
Lidocaine could promote the cuproptosis through up-regulating the long noncoding RNA DNMBP-AS1 in laryngeal cancer
Authors: Yu Yi , Lv Meihong 
Published: May 2023

AbstractBackground:Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis is a copper triggered mitochondrial cell death mode. In this study, we explored the biological effects of lidocaine on laryngeal cancer and studied the relevant mechanisms of cuproptosisMethods:quantitative RT-PCR weas used to measure the expression level of long noncoding RNA (IncRNA) DNMBP-AS1. DNMBP-AS1 siRNA (si-DNMBP-AS1) were transfected into Hep-2 cells to verify the roles of DNMBP-AS1 in cuproptosis. 24 hours treatment with 20 nM elesclomol and 2 µM CuCl2 was performed to promote the occurrence of Cuproptosis. Cell proliferation and apoptosis assays ware utilized to analyze biological effect of lidocaine on Hep-2 cells.Results:DNMBP-AS1 was significantly upregulated during cuproptosis in Hep-2 cells. The si-DNMBP-AS1 significantly increased the cell viability, and suppress the cuproptosis. Lidocaine was cytotoxic to the Hep-2 cells in a dose- and time-dependent manner. Exposure to 10 μM of lidocaine for 24 hours did not reduce the viability, but significantly increased the expression of DNMBP-AS1, and promote the cuproptosis. Anymore, si-DNMBP-AS1 reverse the pro-cuproptosis function of lidocaine.Conclusions:lidocaine was cytotoxic to human laryngeal cancer cells in a time- and dose-dependent manner, promoted the cuproptosis through up-regulating DNMBP-AS1. The results of this study offer initial optimism that lidocaine can be used in an adjuvant or neoadjuvant fashion in laryngeal cancer treatment.
Propagation of Bessel-Gaussian beams through a Spiral Phase Plate: Generation of Donut Humbert beam of type-II
Authors: Chib S. , Khannous F. , Belafhal A. 
Published: May 2023

Abstract
A new family of donut beams known as Humbert beam of type-II (HBII) was developed by converting circular beams (CiBs) that were travelling through an ABCD paraxial optical system with a spiral phase plate (SPP). Either the superposition of the Whittaker, Bessel-modulated, Laguerre, and Hermite beams, can be used to represent the amplitude field of CiBs. The transformation and propagation of CiBs using a SPP after propagating the examined optical system, is shown and deduced in detail. To investigate the comportment of Humbert beams of the type-II in free space and through telescope, numerical simulations are performed.
ARID3A as a potential prognostic biomarker and therapeutic target in colon adenocarcinoma: Insights from a comparative analysis of immune cell infiltration and oxidative stress
Authors: Baldi Salem , He yun , Ivanov Igor , Gao Yaping , Tian hui 
Published: May 2023

Abstract
The tumour microenvironment can be shaped by tumour-infiltrating immune cells that control the fate of immunotherapy effects. Whether ARID3A is associated with immune cell infiltration and oxidative stress in colon adenocarcinoma (COAD) remains unknown. The present study addresses a gap in the literature by performing a comparative analysis of ARID3A expression across multiple databases and investigating its association with immune cell infiltration, which has not been previously reported. ARID3A expression level in COAD were analyzed by the TNMplot and GEPIA2 TCGA databases. The analysis of TCGA databases showed that ARID3A expression was significantly higher in COAD tissues than adjacent normal tissues and associated with poor outcome in COAD patients. Immunohistochemistry staining also revealed varying degrees of ARID3A positivity in malignant colon tissue. Importantly, ARID3A showed a strong negative correlation with tumor-infiltrating NK and CD8 + T cells, which are critical for anti-tumor immunity, and a positive correlation with macrophages and neutrophils infiltration. These results suggest that ARID3A may promote COAD progression and negatively correlate with immune cell infiltration in the tumor microenvironment. Additionally, ARID3A may enhance tumor cell survival by activating the PI3K-AKT-mTOR pathway and inhibiting apoptosis. This study highlights the potential of ARID3A as a prognostic biomarker and a target for COAD diagnosis and therapies. However, further studies are required to investigate the mechanism underlying the observed correlations and validate the findings experimentally.
Proton radiotherapy as a treatment strategy to increase survival in locally advanced pancreatic cancer in the body and tail: a retrospective study
Authors: Ami Katsuya , Terashima Kazuki , Ishida Jun , Suga Masaki , Okawa Taisuke , Takahashi Daiki , Park SungChul , Matsuo Yoshiro , Nanno Yoshihide , Tokumaru Sunao , Okimoto Tomoaki , Toyama Hirochika , Fukumoto Takumi 
Published: May 2023

Abstract
Background: Long-term outcomes and prognostic factors of proton radiotherapy for locally advanced pancreatic cancer (LAPC) in the body and tail are still unknown. The aim of this study was to determine the prognostic factors after proton radiotherapy in a large group of patients with LAPC in the body and tail.
Methods: The medical records of 200 patients with LAPC in the body and tail who underwent proton radiotherapy between February 2009 and January 2021 at the Hyogo Ion Beam Medical Center were retrospectively reviewed to identify prognostic factors that contribute to long-term survival.
Results: The overall survival rate at 1- and 2-year after PT was 69.6% and 35.4% with a median overall survival of 18.4 months. The 1- and 2-year local progression-free, and progression-free survival rates were 84.3% and 68.0%, and 44.3% and 19.4%, respectively. In multivariate analysis, superior mesenteric artery (SMA) invasion (SMA only invasion vs. celiac artery only invasion; P=0.005: SMA and celiac artery invasion vs. celiac artery only invasion; P=0.008), carbohydrate antigen 19-9 (CA 19-9) level ≥ 231.9 U/mL (P<0.001), anterior peripancreatic invasion (P=0.004), and absence of concurrent chemotherapy (P<0.001) were statistically significant prognostic factors for overall survival. There was no significant difference in local progression-free survival; however, distant metastasis-free survival was statistically worse in patients with prognostic factors than in those without.
Conclusions: Proton radiotherapy for LAPC in the body and tail may be a valuable multidisciplinary treatment option. Patients with SMA invasion, higher pre-proton radiotherapy serum CA 19-9 level, anterior peripancreatic invasion, or no concurrent chemotherapy had worse overall survival because of worse distant metastasis-free survival, suggesting that distant metastases have a significant impact on overall survival in such patients.
Trial registration: retrospectively registered
Effects of Hormonal Contraceptives on Lipid Profile among Women Attending Family Planning Unit in Goba Town Public Health Facilities, Bale, Southeast Ethiopia: A Comparative Cross-Sectional Study
Authors: Turki Awel , Ayalew Almaz , Mossie Andualem , Mitiku Shimelis 
Published: May 2023

Abstract

Background
Hormonal contraceptives are a widely used contraceptive method for the prevention of pregnancy in women. It is associated with change in lipid profile which results in congestive heart failure, coronary heart disease, angina, deep vein thrombosis and stroke which are the major cause of premature death. We aim to investigate the effects of hormonal contraceptive use on lipid profile among women attending family planning unit in Goba Town Public Health Facilities.
Methods
A comparative cross-sectional study design was conducted on 93 hormonal contraceptive users and 93 non-users’ women in Goba Town Public Health Facilities from September to November, 2022. Blood samples for the estimation of TC, TG, HDL-c and LDL-c levels were collected. Student's independent t-test was used to compare the results of lipid profiles. One-way ANOVA was used to identify the variation of lipid profile between progestin only pills, DMPA and implant users. Simple linear regression was used to determine the change in lipid profiles in relation to the duration of hormonal contraceptive use. P-value less than 0.05 was considered as statistically significant.
Result
The mean serum level of TC, TG and LDL-c was significantly increases in hormonal contraceptive users in comparison with non-users. The mean serum level TC, TG, LDL-c and HDL-c was significantly different between DMPA, implanon and POP users. The mean serum level of TC, TG and LDL-c in implanon users was lower than DMPA and POP users. As the duration of DMPA and POP use increases, the serum level of TC, TG and LDL-c were significantly increased. But, the serum level of HDL-c was significantly decreased. LDL-c was significantly increased with the duration of implanon use.
Conclusion
The mean serum level of TC, TG and LDL-c were significantly increased among hormonal contraceptive users. The mean serum level of lipid profile was significantly different between DMPA, implanon and POP users. The serum level of TC, TG, LDL-c were directly proportional to the duration of DMPA and POP use. Routine evaluation of lipid profiles is advisable before and after initiation of hormonal contraceptives.
Simulation analysis of evapotranspiration and plant transpiration of the Jujube forests in arid zones based on SIMDual-Kc model and improved S-W model
Authors: Qiao Ying , Wang Huanbo , Ma Yingjie , Xin Mingliang 
Published: May 2023

Abstract
Results The S-W model achieved higher accuracy than the SIMDual-Kc model in simulating the evapotranspiration and plant transpiration of the Jujube forest, but both models met the simulation requirements, are effective tools for estimating the evapotranspiration in Jujube forests .The applicable parameter settings of the SIMDual-Kc model for the Jujube forest in arid zones were: base crop coefficient Kcb = 0.18, 0.7, 0.7; evaporation layer depth Ze = 0.15 m, total evaporation water TEW = 18 mm, easy evaporation water REW = 9 mm, soil water consumption ratio p = 0.5. The appropriate parameter settings of the S-W model were: a1 = 6.9445, g0 = 0.0439, b2 = 4.6041, b3 = 957.1106, and an extinction coefficient of 0.4508. The results provide a theoretical basis for formulating reasonable irrigation systems and irrigation decisions for the Jujube forests in arid zones.