bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membrane Cholesterol Interactions with Proteins in Hypercholesterolemia-Induced Endothelial Dysfunction
Authors: Fancher Ibra S. , Levitan Irena 
Published: July 2023

Abstract
Purpose of Review
The goal of this review is to highlight work identifying mechanisms driving hypercholesterolemia-mediated endothelial dysfunction. We specifically focus on cholesterol-protein interactions and address specific questions related to the impact of hypercholesterolemia on cellular cholesterol and vascular endothelial function. We describe key approaches used to determine the effects of cholesterol-protein interactions in mediating endothelial dysfunction under dyslipidemic conditions.

Recent Findings
The benefits of removing the cholesterol surplus on endothelial function in models of hypercholesterolemia is clear. However, specific mechanisms driving cholesterol-induced endothelial dysfunction need to be determined. In this review, we detail the latest findings describing cholesterol-mediated endothelial dysfunction, highlighting our studies indicating that cholesterol suppresses endothelial Kir2.1 channels as a major underlying mechanism.

Summary
The findings detailed in this review support the targeting of cholesterol-induced suppression of proteins in restoring endothelial function in dyslipidemic conditions. The identification of similar mechanisms regarding other cholesterol-endothelial protein interactions is warranted.
Protective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Adult Male Albino Rats: Histological and Immunohistochemical Study
Authors: Kelada Melad N. , Elagawany Amany , El Sekily Nancy Mohamed , El Mallah Mona , Abou Nazel Maha W. 
Published: July 2023

AbstractCisplatin is a potent antineoplastic drug that is used for treatment of many solid tumors. It has a wide range of adverse effects. Nephrotoxicity is the most common one of them. Platelet-rich plasma (PRP) is an autologous human plasma that activates the tissue regeneration through cell proliferation and differentiation. Study the role of PRP in amelioration of cisplatin-induced nephrotoxicity on the kidney of adult male albino rats by biochemical, morphometric, histological, and immunohistochemical studies. Thirty-five adult male albino rats were used. Thirty rats were included as experimental group and five were used to obtain the PRP. The experimental group was classified into as follows: control group which received 1mL of sterile saline by intraperitoneal injection (IP), cisplatin-treated group which received cisplatin 7.5 mg/kg IP in a single dose and cisplatin and PRP-treated group rats received cisplatin 7.5 mg/kg single IP dose followed by 1ml of PRP IP after 24 h of cisplatin injection. There was a significant increase in urea and creatinine levels in cisplatin-treated group in comparison to the control and the PRP groups. The kidneys of cisplatin-treated group showed distorted renal structure, where specimens of PRP-treated group revealed restoration of the classical appearance of the renal tissue similar to the control group. PRP has protective effects on renal structure and functions and it helps to ameliorate the histological changes induced by cisplatin.
SEOM-GECP Clinical guidelines for diagnosis, treatment and follow-up of small-cell lung cancer (SCLC) (2022)
Authors: García-Campelo Rosario , Sullivan Ivana , Arriola Edurne , Insa Amelia , Juan Vidal Oscar , Cruz-Castellanos Patricia , Morán Teresa , Reguart Noemí , Zugazagoitia Jon , Dómine Manuel 
Published: July 2023

AbstractSmall-cell lung cancer (SCLC) is a highly aggressive malignancy comprising approximately 15% of lung cancers. Only one-third of patients are diagnosed at limited-stage (LS). Surgical resection can be curative in early stages, followed by platinum–etoposide adjuvant therapy, although only a minority of patients with SCLC qualify for surgery. Concurrent chemo-radiotherapy is the standard of care for LS-SCLC that is not surgically resectable, followed by prophylactic cranial irradiation (PCI) for patients without progression. For extensive-stage (ES)-SCLC, a combination of platinum and etoposide has historically been a mainstay of treatment. Recently, the efficacy of programmed death-ligand 1 inhibitors combined with chemotherapy has become the new front-line standard of care for ES-SCLC. Emerging knowledge regarding SCLC biology, including genomic characterization and molecular subtyping, and new treatment approaches will potentially lead to advances in SCLC patient care.
Self-help management of patients undergoing chemotherapy: analysis of the online forum of the women’s self-help association against cancer
Authors: Colditz C. , Keinki C. , Huebner J. 
Published: July 2023

Abstract
Purpose
The aim of this study was to examine threads on chemotherapy in the largest German self-help forum regarding content and emotions.

Methods
All threads on the subject of chemotherapy that were published by February 6th, 2022 were included in the category “drug therapy”. A total of 50 threads were analyzed. A quantitative analysis was carried out with regard to content, emotions, number of replies, number of hits, duration of the conversation, duration of access in days, number density of replies, and hits per day.

Results
16 threads are about side effects and in 18 threads, the emotion is fear. Threads in which the emotion fear was expressed have the highest number of replies at 3367. Shared therapy successes are posted with pleasure and achieved a higher mean value for the duration of conversation with 1374.25 days.

Conclusion
An online self-help forum is a very important source of psychosocial support for patients undergoing chemotherapy.
The impact of COVID-19 on supply chains: systematic review and future research directions
Authors: Younis Hassan , Alsharairi Malek , Younes Hammad , Sundarakani Balan 
Published: July 2023

AbstractThe purpose of this research is to investigate how COVID-19 impacted supply chains and to develop future research directions from thereof. Using a systematic literature review methodology, this study analyzes publications on Google Scholar and Scopus that explored the impact of COVID-19 on supply chains. The research thoroughly reviews and analyzes a total of 95 studies that were found relevant and significant. COVID-19 had a significant impact on supply chains and organizations a like and therefore the study has revealed the following findings. Although some scholars claim that the pandemic revealed the fragility of supply chains, brought many logistical activities to standstill, and completely disrupted markets, but other researchers found that it has also created unlimited opportunities for organizations and industries. This review concluded that extant of literature falls into four themes; those who believe that COVID-19 was a complete threat, researchers who believe that it was both a threat and opportunity, those who believe it created enormous opportunities and lastly scholars who proposed a model that can help mitigate the impact of the pandemic on supply chains. This study opens the door wide for other researchers to explore how COVID-19 pandemic impacted supply chains positively and negatively across many industries and contexts. The study also provides an easy reference for business managers who are interested in knowing what would be the consequences of such pandemic on their organizations and how to take the right decisions that can help mitigate the many threats while at the same time maximize any opportunities created.
New species and new records of bryozoan species from fouling communities in the Madeira Archipelago (NE Atlantic)
Authors: Souto Javier , Ramalhosa Patrício , Ferrario Jasmine , Png-Gonzalez Lydia , Álvarez Soledad , Gestoso Ignacio , Nogueira Natacha , Canning-Clode João 
Published: July 2023

AbstractHull fouling is considered to be the most significant vector of introduction of marine non-indigenous species (NIS) in the Madeira Archipelago (NE Atlantic) because these islands provide a vital passage route for many ships. The transfer of species between boat hulls and artificial substrates in marinas is known to be high. Bryozoans are among the most common groups of marine invertebrates growing on this type of substrate. In recent years, significant advances have been made in our knowledge about the biodiversity of bryozoans in the Madeira Archipelago. Nonetheless, the currently recognized numbers remain far from reflecting the actual bryozoan species richness. In this context, we examine bryozoan samples stemming from NIS monitoring surveys on artificial substrates along the southern coast of the Madeira Archipelago, in four recreational marinas and in two offshore aquaculture farms. This has yielded new information about ten bryozoan species. Two of them, Crisia noronhaisp. nov. andAmathia maderensissp. nov., are described for the first time, although at least the first one was previously recorded from Madeira but misidentified.Bugula ingens,Cradoscrupocellaria insularis,Scruparia ambigua, andCelleporaria brunneaare recorded for the first time in Madeira. Moreover, the material ofC. brunneawas compared with the type, and a biometric analysis was performed with material from the Atlantic and Mediterranean. All samples identified asC. brunneain both regions are the same species, and the variations described in the literature apparently reflect high intracolonial variability. Finally, we provide new information for the descriptions of 4 additional bryozoans, namely,Crisiasp. aff. elongata,Cradoscrupocellaria bertholletii,Scrupocaberea maderensis, andTricellaria inopinata.
Influence of Recycled Concrete Aggregates on the California Bearing Ratio (CBR) of Granular Sub-bases
Authors: Salcedo Fontalvo José Eduardo , Vega Araujo Daniela Lucia , Ariza Polo Lucia , Padilla Quiroz Justin , Castro Cabeza Andrea 
Published: July 2023

AbstractRecycled concrete aggregates (RCAs) have a high potential to be used as replacements for natural aggregates in the construction of pavements with similar or even better characteristics. This paper evaluates the influence of RCA as a partial replacement in a granular sub-base of 37.5 mm nominal maximum size (GSB38). Specifically, two replacement percentages of RCA by weight of the coarse aggregate of the GSB38 were evaluated: 10 and 15. To estimate the influence on the mechanical behavior, abrasion tests were carried out in the Los Angeles (LA) abrasion and California bearing ratio (CBR) methods. For GSB38, the average abrasion results were 30.54%. The CBR for the same material at a penetration of 0.254 cm was 26.90, 61.00 and 76.20% and at a penetration of 0.508 cm was 33.00, 65.70 and 82.00% for 10, 25 and 56 blows per layer, respectively. For GSB38 with 10% RCA, similar and even better behavior than natural GSB38 was found in terms of LA abrasion, with an average result of 38.68%. The CBR for the same alternative at a penetration of 0.254 cm was 13.20, 52.80 and 57.70% and at a penetration of 0.508 cm was 18.00, 61.30 and 68.90% for 10, 25 and 56 blows per layer, respectively. But GSB38 with 15% RCA showed an average abrasion of 45.51%, indicating a decrease compared with natural GSB38 and GSB38 with 10% RCA. The CBR for the same alternative also shows a decreasing trend.
Investigations on the influence of manufacturing and curing effects on the properties of structural-glazing adhesives subjected to tensile stresses
Authors: Müller Paul , Schuler Christian , Siebert Geralt 
Published: July 2023

AbstractDemand for structural glazing joints has increased considerably in recent years due to the ever-increasing loads resulting from growing dimensions, especially in spectacular glass structures. Within the scope of planning and production monitoring, existing influences are analyzed based on the standard H-sample from the current structural glazing guidelines. These guidelines do not define any specific methodology or guidance for manufacturing test specimens. For determining load-bearing properties, various parameters, such as specimen age and curing condition, have a relevant influence during and after manufacturing. This study aims to investigate the manufacturing process for H-specimens systematically to identify and minimize the interfering influences. On this basis, the influence of the curing of modified H-specimens was investigated in detail for specimens under tensile load. Next to curing at room temperature, tempering at 40 °C was investigated for two different H-joint geometries. Thereby, a relevant influence of specimen age and different curing conditions on the strength as well as stiffness properties could be determined. As one result of the study, the curing time can be shortened by tempering the specimens in relation to the specified 28 days by ETAG 002-1. For calculation methods used in practice, like the structural spring method, suggestions for statistically validated strength and stiffness parameters representing the load-bearing behavior are proposed, considering the adhesive’s curing state and the joint’s nominal stress.
The Gut Microbiota: a Novel Player in the Pathogenesis of Uterine Fibroids
Authors: K Vineetha K , Bhat Rajeshwari G , Rao Bhamini Krishna , R Archana P 
Published: July 2023

AbstractUterine fibroid is a common gynecological disorder that affects women of reproductive age and has emerged as a major public health concern. The symptoms have a negative influence on both their physical health and quality of life. The cost of treatment has a significant impact on the disease’s burden. Even though its origin is uncertain, estrogen is thought to be a key player in fibroid pathophysiology. Many theories, including those based on genetic and environmental factors, explain what causes hyper-estrogenic condition in fibroid patients. One such possibility that is currently being explored is the hypothesis that an altered gut microbiome can contribute to the development of diseases characterized by estrogen dominance. Gut dysbiosis is often a “hot area” in the health sciences. According to a recent study, uterine fibroid patients have altered gut microbiome. A variety of risk factors influence both fibroid development and gut homeostasis. Diet, lifestyle, physical activity, and environmental contaminants have an impact on estrogen and the gut flora. A better understanding of uterine fibroids’ pathophysiology is required to develop effective preventative and treatment options. A few ways by which the gut microbiota contributes to UF include estrogen, impaired immune function, inflammation, and altered gut metabolites. Therefore, in the future, while treating fibroid patients, various strategies to deal with changes in the gut flora may be advantageous. For developing suggestions for clinical diagnosis and therapy, we reviewed the literature on the relationship between uterine fibroids and the gut microbiota.
Impact of the interface on the fatigue life of steel-based explosively welded heterostructured plates
Authors: Derda Szymon , Karolczuk Aleksander , Robak Grzegorz , Prażmowski Mariusz , Paul Henryk , Łagoda Tadeusz , Gupta Munish Kumar 
Published: July 2023

Abstract
Melted zones, microcracks, shear bands, and elastic incompatibility of explosively welded materials are features that may initialize cracks at the interface and reduce fatigue strength. This study aims to determine the effect of interfacial defect-like structures on the fatigue strength of explosively welded corrosion-resistant plates. Cyclic axial loading was applied to seven distinct layer-by-layer compositions of Ti Gr 1, Zr 700 alloys, and carbon steels. The interfacial wave height as a metric of potential fatigue life influencing factors along with measured strain amplitude was applied as the input quantities for the Machine Learning based model, i.e. the Gaussian process for regression (GPR). This is a novel and successful application of GPR to estimate the effect of interfacial wave height on the fatigue life of explosively welded plates. For the first time, the effect of the interface feature on fatigue life was estimated quantitatively. The Digital Image Correlation technique was applied to measure the field of cyclic strain for the purpose of verifying if a single strain amplitude is representative of a heterostructured plate. It was found that interfacial wave height is an important feature and its increase by 100 µm reduces the fatigue life of analysed plates by 36%. Additionally, to validate the applicability of explosively welded plates to engineering structures under cyclic loading, the experimental fatigue lives were compared with the design curve of the American Society of Mechanical Engineers (ASME) code.
Cefepime extended infusion versus intermittent infusion: Clinical and cost evaluation
Authors: Khole Aalok V. , Dionne Emily , Zitek-Morrison Emily , Campion Maureen 
Published: July 2023

Abstract

Background:
Extended infusion cefepime (1 gram every 6 hours administered over 3 hours) achieves pharmacodynamic efficacy against bacteria with a MIC of ≤8 mg/L in Monte Carlo simulations. This regimen has not been evaluated in clinical practice.

Objective:
Compare clinical and economic outcomes for cefepime by intermittent infusion and by extended infusion in the acute-care setting.

Design:
Single-center, retrospective cohort study.

Setting:
Tertiary-care academic medical center.

Patients:
Hospitalized adults who received cefepime between August 2016 and July 2018 with a diagnosis of sepsis or pneumonia.

Methods:
Clinical and economic outcomes were compared for patients who received empiric cefepime via intermittent infusion (30-minute infusion of 2 g every 8 hours) or extended infusion (3-hour infusion of 1 g every 6 hours). Clinical outcomes analyses were carried out using appropriate statistical methods.

Results:
Overall, 111 patients received intermittent infusion and 93 patients received extended infusion. Approximately half of the included patients had a positive culture for a bacterial pathogen (intermittent infusion 45.9% vs extended infusion 47.3%). Median hospital length of stay (intermittent infusion 6 days vs extended infusion 6 days; P = .67) and 90-day readmission rates (intermittent infusion 61.3% vs extended infusion 67.7%; P = .34) did not differ between the groups. Mortality was infrequent in both groups (intermittent infusion 2.9% vs extended infusion 1.5%; P = .45). Cefepime cost per patient was lower with cefepime by extended infusion: average total daily cost $86.06 for intermittent infusion versus $43.39 for extended infusion.

Conclusions:
Cefepime via extended infusion (4 grams/day) did not differ in clinical outcomes compared to intermittent infusion (6 grams/day) but reduced drug expenditure. Prospective, multicenter, high-quality studies should be conducted to evaluate a mortality difference between these regimens.
Downstream Human Rights Due Diligence: Informing Debate Through Insights from Business Practice
Authors: Hogan Benn F. , Reyes Joanna 
Published: July 2023

Abstract
The United Nations Guiding Principles on Business and Human Rights conceive of human rights due diligence (HRDD) as covering potential impacts across value chains, including downstream. The proposed EU Corporate Sustainability Due Diligence Directive and the revision process of the OECD Guidelines for Multinational Enterprises have sparked renewed discussion on how and whether companies should conduct HRDD downstream to identify and prevent or mitigate adverse human rights impacts. Whilst some debate has occurred previously on downstream HRDD, this has predominantly centred on specific sectors, products and services where the links to egregious human rights harms may be more readily identifiable. This piece seeks to inform the current debate by broadening the examples of sectors, products and services and current business practice which demonstrate the critical need for, and ability of, companies to consider human rights risks downstream.
Sensory Modality and Perceptual Reasons
Authors: Grzankowski Alex , Schroeder Mark 
Published: July 2023

Abstract
Perception can provide us with a privileged source of evidence about the external world – evidence that makes it rational to believe things about the world. In Reasons First, Mark Schroeder offers a new view on how perception does so. The central motivation behind Schroeder's account is to offer an answer to what evidence perception equips us with according to which it is what he calls world-implicating but non-factive, and thereby to glean some of the key advantages of both externalism and internalism, respectively. He answers this motivation by developing a more specific view that he calls the Apparent Factive Attitude view, which pairs an answer to what evidence is provided by a perceptual experience with an answer to why having that perceptual experience provides you with that evidence. In this paper, we advance two interconnected problems for Schroeder's Apparent Factive Attitude view. A traditional intuitive judgment that often motivates internalists is the idea that internal duplicates must necessarily be equally rational in whatever beliefs they have. Schroeder's arguments rely on a weaker claim – that people who are both internal and historical external duplicates but differ only in the veridicality of a single perceptual experience must be equally rational in whatever beliefs they have. In this way he preserves what he argues to be a more compelling internalist intuition. But our arguments will show that Schroeder's view is committed to denying an even more compelling internalist intuition yet – that internal duplicates must have the same phenomenology.
Impact of mandatory nucleic acid amplification test (NAAT) testing approval on hospital-onset Clostridioides difficile infection (HO-CDI) rates: A diagnostic stewardship intervention
Authors: McCormick Winston L. , Jackson Gail , Andrea Sarah B. , Whitehead Valerie , Chargualaf Tiffany L. , Touzard-Romo Francine 
Published: July 2023

AbstractMisclassification of Clostridioides difficile colonization as hospital-onset C. difficile infection (HO-CDI) can lead to unnecessary treatment of patients and substantial financial penalties for hospitals. We successfully implemented mandatory C. difficile PCR testing approval as a strategy to optimize testing, which was associated with a significant decline in the monthly incidence of HO-CDI rates and lowering of our standardized infection ratio to 0.77 (from 1.03) 18 months after this intervention. Approval request served as an educational opportunity to promote mindful testing and accurate diagnosis of HO-CDI.