bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of land-sea breeze on PM$$_{2.5}$$ prediction in central and southern Taiwan using composite neural network
Authors: Kibirige George William , Huang Chiao Cheng , Liu Chao Lin , Chen Meng Chang 
Published: March 2023

AbstractPM$$_{2.5}$$

2.5

prediction plays an important role for governments in establishing policies to control the emission of excessive atmospheric pollutants to protect the health of citizens. However, traditional machine learning methods that use data collected from ground-level monitoring stations have reached their limit with poor model generalization and insufficient data. We propose a composite neural network trained with aerosol optical depth (AOD) and weather data collected from satellites, as well as interpolated ocean wind features. We investigate the model outputs of different components of the composite neural network, concluding that the proposed composite neural network architecture yields significant improvements in overall performance compared to each component and the ensemble model benchmarks. The monthly analysis also demonstrates the superiority of the proposed architecture for stations where land-sea breezes frequently occur in the southern and central Taiwan in the months when land-sea breeze dominates the accumulation of PM$$_{2.5}$$

2.5

.
The inhibitory effect and mechanism of Resina Draconis on the proliferation of MCF-7 breast cancer cells: a network pharmacology-based analysis
Authors: Lv Yana , Mou Yan , Su Jing , Liu Shifang , Ding Xuan , Yuan Yin , Li Ge , Li Guang 
Published: March 2023

AbstractResina Draconis (RD) is known as the "holy medicine for promoting blood circulation" and possesses antitumor properties against various types of cancer, including breast cancer (BC); however, the underlying mechanism is not well understood. To explore the potential mechanism of RD against BC using network pharmacology and experimental validation, data on bioactive compounds, potential targets of RD, and related genes of BC were obtained from multiple public databases. Gene Ontology (GO) and KEGG pathway analyses were performed via the DAVID database. Protein interactions were downloaded from the STRING database. The mRNA and protein expression levels and survival analysis of the hub targets were analyzed using the UALCAN, HPA, Kaplan‒Meier mapper, and cBioPortal databases. Subsequently, molecular docking was used to verify the selected key ingredients and hub targets. Finally, the predicted results of network pharmacology methods were verified by cell experiments. In total, 160 active ingredients were obtained, and 148 RD target genes for the treatment of BC were identified. KEGG pathway analysis indicated that RD exerted its therapeutic effects on BC by regulating multiple pathways. Of these, the PI3K-AKT pathway was indicated to play an important role. In addition, RD treatment of BC seemed to involve the regulation of hub targets that were identified based on PPI interaction network analysis. Validation in different databases showed that AKT1, ESR1, HSP90AA1, CASP3, SRC and MDM2 may be involved in the carcinogenesis and progression of BC and that ESR1, IGF1 and HSP90AA1 were correlated with worse overall survival (OS) in BC patients. Molecular docking results showed that 103 active compounds have good binding activity with the hub targets, among which flavonoid compounds were the most important active components. Therefore, the sanguis draconis flavones (SDF) were selected for subsequent cell experiments. The experimental results showed that SDF significantly inhibited the cell cycle and cell proliferation of MCF-7 cells through the PI3K/AKT pathway and induced MCF-7 cell apoptosis. This study has preliminarily reported on the active ingredients, potential targets, and molecular mechanism of RD against BC, and RD was shown to exert its therapeutic effects on BC by regulating the PI3K/AKT pathway and related gene targets. Importantly, our work could provide a theoretical basis for further study of the complex anti-BC mechanism of RD.
Novel methods for reliability study of multi-dimensional non-linear dynamic systems
Authors: Gaidai Oleg , Xu Jingxiang , Yan Ping , Xing Yihan , Wang Kelin , Liu Zirui 
Published: March 2023

AbstractThis research presents two unique techniques for engineering system reliability analysis of multi-dimensional non-linear dynamic structures. First, the structural reliability technique works best for multi-dimensional structural responses that have been either numerically simulated or measured over a long enough length to produce an ergodic time series. Second, a novel extreme value prediction method that can be used in various engineering applications is proposed. In contrast to those currently used in engineering reliability methodologies, the novel method is easy to use, and even a limited amount of data can still be used to obtain robust system failure estimates. As demonstrated in this work, proposed methods also provide accurate confidence bands for system failure levels in the case of real-life measured structural response. Additionally, traditional reliability approaches that deal with time series do not have the benefit of being able to handle a system's high dimensionality and cross-correlation across several dimensions readily. Container ship that experiences significant deck panel pressures and high roll angles when travelling in bad weather was selected as the example for this study. The main concern for ship transportation is the potential loss of cargo owing to violent movements. Simulating such a situation is difficult since waves and ship motions are non-stationary and complicatedly non-linear. Extreme movements greatly enhance the role of nonlinearities, activating effects of second and higher order. Furthermore, laboratory testing may also be called into doubt due to the scale and the choice of the sea state. Therefore, data collected from actual ships during difficult weather journeys offer a unique perspective on the statistics of ship movements. This work aims to benchmark state-of-the-art methods, making it possible to extract necessary information about the extreme response from available on-board measured time histories. Both suggested methods can be used in combination, making them attractive and ready to use for engineers. Methods proposed in this paper open up possibilities to predict simply yet efficiently system failure probability for non-linear multi-dimensional dynamic structure.
Quantitative electroencephalographic biomarker of pharmacological treatment response in patients with anxiety disorder: a retrospective study
Authors: Byeon Jun , Moon Jung Yeon , Je Se Ryoung , Park So Hyun , Kim Jun Won 
Published: March 2023

AbstractThis study aimed to investigate the effectiveness of a quantitative electroencephalography (qEEG) biomarker in predicting the response to pharmacological treatment in patients with anxiety disorder. A total of 86 patients were diagnosed with anxiety disorder according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition, and subsequently treated with antidepressants. After 8–12 weeks, the participants were divided into treatment-resistant (TRS) and treatment-response (TRP) groups based on their Clinical Global Impressions-Severity (CGI-S) scores. We obtained the absolute-EEG measurements for 19-channels and analyzed qEEG findings according to the frequency range: delta, theta, alpha, and beta. The beta-wave was subdivided into low-beta, beta, and high-beta waves. The theta-beta ratio (TBR) was calculated, and an analysis of covariance was performed. Of the 86 patients with anxiety disorder, 56 patients (65%) were classified in the TRS group. The TRS and TRP groups did not differ in terms of age, sex, or medication-dosage. However, the baseline CGI-S was higher in the TRP group. After calibration by covariates, the TRP group showed higher beta-waves in T3 and T4, and a lower TBR, especially in T3 and T4, than the TRS group. These results indicate that patients with a lower TBR and higher beta and high-beta waves in T3 and T4 are more likely to respond to medication.
The DNA damage response pathway regulates the expression of the immune checkpoint CD47
Authors: Ghantous Lucy , Volman Yael , Hefez Ruth , Wald Ori , Stern Esther , Friehmann Tomer , Chajut Ayelet , Bremer Edwin , Elhalel Michal Dranitzki , Rachmilewitz Jacob 
Published: March 2023

AbstractCD47 is a cell surface ligand expressed on all nucleated cells. It is a unique immune checkpoint protein acting as “don’t eat me” signal to prevent phagocytosis and is constitutively overexpressed in many tumors. However, the underlying mechanism(s) for CD47 overexpression is not clear. Here, we show that irradiation (IR) as well as various other genotoxic agents induce elevated expression of CD47. This upregulation correlates with the extent of residual double-strand breaks (DSBs) as determined by γH2AX staining. Interestingly, cells lacking mre-11, a component of the MRE11-RAD50-NBS1 (MRN) complex that plays a central role in DSB repair, or cells treated with the mre-11 inhibitor, mirin, fail to elevate the expression of CD47 upon DNA damage. On the other hand, both p53 and NF-κB pathways or cell-cycle arrest do not play a role in CD47 upregualtion upon DNA damage. We further show that CD47 expression is upregulated in livers harvested from mice treated with the DNA-damage inducing agent Diethylnitrosamine (DEN) and in cisplatin-treated mesothelioma tumors. Hence, our results indicate that CD47 is upregulated following DNA damage in a mre-11-dependent manner. Chronic DNA damage response in cancer cells might contribute to constitutive elevated expression of CD47 and promote immune evasion.
A preliminary study to identify existing drugs for potential repurposing in breast cancer based on side effect profile
Authors: Rymbai Emdormi , Sugumar Deepa , Krishnamurthy Praveen Thaggikuppe , Selvaraj Divakar , Vasu Soumya , Priya Shiva , Jayaram Saravanan 
Published: March 2023

AbstractBreast cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women after lung cancer. The present study aims to identify potential drug candidates using the PROMISCUOUS database for breast cancer based on side effect profile and then proceed with in silico and in vitro studies. PROMISCUOUS database was used to construct a group of drugs that share maximum side effects with letrozole. Based on the existing literature, ropinirole, risperidone, pregabalin, and gabapentin were selected for in silico and in vitro studies. The molecular docking was carried out using AUTODOCK 4.2.6. MCF-7 cell line was used to evaluate the anti-cancer activity of the selected drugs. PROMISCUOUS database revealed that as many as 23 existing drugs shared between 62 and 79 side-effects with letrozole. From docking result, we found that, ropinirole showed a good binding affinity (−7.7 kcal/mol) against aromatase compared to letrozole (−7.1 kcal/mol) which was followed by gabapentin (−6.4 kcal/mol), pregabalin (−5.7 kcal/mol) and risperidone (−5.1 kcal/mol). From the in vitro results, ropinirole and risperidone showed good anti-cancer activity of IC50 with 40.85±11.02 μg/ml and 43.10±9.58 μg/ml cell viability. Based on this study results and existing literature we conclude that risperidone, pregabalin, and gabapentin are not ideal candidates for repurposing in breast cancer but ropinirole could be an excellent choice for repurposing in breast cancer after further studies.
Empfehlungen der DEGUM zu diagnostischen Punktionen in der Pränatalmedizin
Authors: Kähler Christiane , Faber Renaldo , Geipel Annegret , Heling Kai-Sven , Kagan Karl-Oliver , Kozlowski Peter , Schramm Thomas 
Published: March 2023

ZusammenfassungDiagnostische Punktionen (Amniozentese, Chorionzottenbiopsie und Fetalblutentnahme) sind ein wesentlicher Bestandteil der Pränataldiagnostik und die einzige etablierte und wissenschaftlich ausreichend evaluierte Möglichkeit der Diagnostik genetischer Erkrankungen aus schwangerschaftsspezifischen Zellen. Die Anzahl diagnostischer Punktionen in Deutschland ist, wie in anderen Ländern, deutlich gesunken. Dies ist maßgeblich auf die Einführung des Ersttrimester-Screenings mit weiterführender detaillierter Ultraschalluntersuchung des Fetus und die Analyse von cf-DNA (cell-free DNA) aus maternalem Blut (sogenannter „Nicht Invasiver Pränataler Test“ – NIPT) zurückzuführen. Andererseits sind die Erkenntnisse über die Inzidenz und das Erscheinungsbild genetischer Erkrankungen gestiegen. Die Entwicklung moderner molekulargenetischer Techniken (Mikroarray- und Exom-Analyse) macht eine differenzierte Untersuchung dieser Erkrankungen mehr und mehr möglich. Die Anforderungen an Aufklärung und Beratung über diese komplexen Zusammenhänge sind dadurch wesentlich höher geworden. Die Studien der letzten Jahre machen deutlich, dass diagnostische Punktionen, die in Expertenzentren durchgeführt werden, mit einem niedrigen Risiko für Komplikationen assoziiert sind. Insbesondere der eingriffsbedingte Abort unterscheidet sich kaum vom Hintergrundrisiko für einen Spontanabort. Die Sektion Gynäkologie und Geburtshilfe der Deutschen Gesellschaft für Ultraschall in der Medizin (DEGUM) hat im Jahr 2013 Empfehlungen zu diagnostischen Punktionen in der Pränatalmedizin publiziert 1. Die oben geschilderten Entwicklungen und neuen Erkenntnisse der letzten Jahre machen eine Revision und Neuformulierung dieser Empfehlungen nötig. Ziel dieser Übersicht ist eine Zusammenstellung wichtiger und aktueller Fakten zu pränatalmedizinischen Punktionen (u.a. Technik, Komplikationen, genetische Untersuchungen). Sie soll der grundlegenden umfassenden und aktuellen Information über diagnostische Punktionen in der Pränatalmedizin dienen. Sie ersetzt die Publikation von 2013 1.
Pyroverbot Silvester 2020 & 2021 – Analyse von feuerwerksbedingten Verletzungen der letzten 12 Jahre
Authors: Diederich Linda Manuela , Pudszuhn Annett , Hofmann Veit Maria 
Published: March 2023

ZusammenfassungZum Jahreswechsel kommt es in Deutschland zu Verletzungen durch Feuerwerkskörper. Das
Gehör betreffend werden Knall- (KT) und Explosionstrauma (ET) unterschieden. Die Studie
untersucht Prävalenz und Charakteristika von feuerwerksbedingten Verletzungen und die
Auswirkungen des aufgrund der COVID-19-Pandemie verordneten Pyroverbots an Silvester 2020/21
und 2021/22 im Vergleich zum 10-Jahres-Zeitraum vor der Pandemie.Eine retrospektive Untersuchung von Patienten, die sich mit den Diagnosen KT (H83.3) oder
ET (T70.8) in den letzten 12 Jahren in den Rettungsstellen der Charité vom 28.12. bis zum 05.01.
vorstellten, wurde durchgeführt.Es wurden 276 Patienten erfasst, die zu 77% männlich waren. Jeweils ein Drittel waren der
Altersgruppe 10–19 und 20–29 Jahre zuzuordnen. 21% der Patienten wurden stationär aufgenommen.
Es kam in 67% zu einem isolierten KT des Ohres, in 11% zu Hand-, in 8% zu Kopf- und in 4% zu
Augenverletzungen. Bei 87% kam es zu einer Ohrbeteiligung mit Hörminderung, davon 5% mit
ET.Eine operative Versorgung fand bei 8% der Patienten statt. Die Behandlung einer
Trommelfellperforation erfolgte in 54% durch Schienung und in 38% durch eine Tympanoplastik.
Eine Therapie mit einem Glukokortikoid wurde in 48 % i.v. und in 20% oral eingeleitet.
Insgesamt kam es zu einer Abnahme von Verletzungen im Jahr 2020 und 2021 von fast 75% im
Vergleich zum vorherigen 10-Jahres-Zeitraum.Die Anwendung von Feuerwerk führte zu einer erhöhten Nutzung des Gesundheitssystems. Das
Verkaufsverbot von Pyrotechnik wie auch die Einführung von Pyroverbotszonen 2020 und 2021
führten zu einem relevanten Rückgang von Verletzungen. 2020 und 2021 waren die einzigen Jahre,
in denen Verletzungen bei Kindern ausblieben. Das KT des Ohres ist die häufigste
feuerwerksbedingte Verletzung.
Veränderung der therapeutischen Beziehung in Folge eines
coronabedingten Wechsel von Präsenz- zu Videotherapiesitzungen: Eine
qualitative Analyse von Therapeut*inneninterviews
Authors: Bechtold Sara , Hall Mila , Scherner Paloma Valerie , Kaven Leonie , Rubel Julian 
Published: March 2023

Zusammenfassung
Ziel der Studie Ziel dieser Studie war es, zu untersuchen, inwiefern sich
die therapeutische Beziehung durch die COVID-19-bedingte Umstellung von
Präsenz- auf Video-Therapie verändert hat.
Methode Es wurden halb-strukturierte Interviews mit 21
Psychotherapeut*innen durchgeführt, die ihre Therapien im Zuge
der Pandemie von Präsenz- auf Videotherapie-Sitzungen umgestellt hatten.
Die Interviews wurden anschließend transkribiert und im Rahmen einer
qualitativen Analyse ausgewertet.
Ergebnisse Mehr als die Hälfte der Therapeut*innen
berichteten, dass die therapeutische Beziehung zu ihren Patient*innen
weiterhin stabil blieb. Dennoch beschreibt ein Großteil der
Therapeut*innen Unsicherheiten im Umgang mit nonverbalen Signalen und
mit der Distanz zu den Patient*innen. Es wird sowohl eine Verbesserung,
als auch eine Verschlechterung der therapeutischen Beziehung wahrgenommen.
Diskussion Die Stabilität der therapeutischen Beziehung kann vor
allem auf den vorherigen Präsenzkontakt zurückgeführt
werden. Die geäußerten Unsicherheiten könnten als
Risikofaktoren für die therapeutische Beziehung gedeutet werden. Obwohl
die Stichprobe nur einen kleinen Teil praktizierender Therapeut*innen
repräsentiert, stellen die Erkenntnisse aus dieser Studie einen
wichtigen Beitrag für unser Verständnis davon dar, wie sich
Psychotherapie durch die COVID-19-Pandemie verändert hat.
Schlussfolgerung Die Qualität der therapeutischen Beziehung wurde
von der überwiegenden Mehrzahl der Therapeut*innen trotz des
Wechsels von Präsenz- auf Video-Therapie als stabil beschrieben.
Myomodulation Using Botulinum Toxin in Septorhinoplasty for Crooked Noses: Introducing the Concept and Application of Nasal Muscle Imbalance Theory
Authors: Wong Eugene Hung Chih , D'Souza Alwyn 
Published: March 2023

AbstractThe role of septorhinoplasty for adequate correction of deviated nose is well documented, but the rationales and patterns for recurrences after proper rhinoplasty remain unclear. There has also been little attention given to the influence of nasal musculatures on the stability of nasal structures after septorhinoplasty. The aim of this article is to propose our nasal muscle imbalance theory, which may explain the potential reason for redeviation of the noses in the initial period after septorhinoplasty. We postulate that in a chronically deviated nose, the nasal muscles on the convex side will be stretched and develop hypertrophy after prolonged period of increased contractile activity. On the contrary, the nasal muscles on the concave side will undergo atrophy due to reduced load requirement. In the initial period of recovery after a septorhinoplasty to bring the nose back to midline, this muscle imbalance is still uncorrected with unequal pulling forces on the nasal structure because the stronger nasal muscles on the previously convex side is still hypertrophied and exert stronger forces compared with the previously concave side, therefore increasing the risk of redeviation of the nose back to the preoperative side until muscle atrophy occurs in the convex side and a balanced nasal muscle pull is achieved. We believe that postseptorhinoplasty botulinum toxin injections can be used as an adjunct in rhinoplasty surgery to effectively block the pulling actions of the stronger or overacting nasal muscles by speeding up the atrophy process while allowing patient's nose to heal and stabilize in the desired position. However, further studies to objectively confirm this hypothesis is required, which include comparing topographic measurements, imaging and electromyography signals before and after injections in postseptorhinoplasty patients. The authors have already planned a multicenter study to further evaluate this theory.
Re-evaluation of P-Chiral, N-Phosphoryl Sulfonamide Brønsted Acids in the Asymmetric Synthesis of 1,2,3,4-Tetrahydroquinoline-2-carboxylate Esters via Biomimetic Transfer Hydrogenation
Authors: Tsantrizos Youla S. , Mbaezue Ifenna I. , Topic Filip 
Published: March 2023

AbstractEnantioenriched heterocyclic and rigidified bioisosteres of amino acids are valuable building blocks in drug discovery, particularly in the design of peptidomimetic drugs. The rigidified bioisostere of phenylalanine, 1,2,3,4-tetrahydroquinoline-2-carboxylic acid, is found in several biologically active compounds. However, only a small number of successful methodologies have been reported for its asymmetric synthesis. To develop an environmentally benign and metal-free organocatalytic process for the preparation of this compound, a number of novel P-chiral, N-phosphoryl sulfonamide Brønsted acids were synthesized and evaluated in a biomimetic transfer hydrogenation reaction of quinoline-2-carboxylates to give the (R)-1,2,3,4-tetrahydroquinoline-2-carboxylates.
Use of Carbonyldiimidazole as an Activator of Formic Acid in a Tris(dibenzylideneacetone)dipalladium-Catalyzed Formylation of Aryl Iodides
Authors: Karmakar Sukhen , Nadhagopal Sundar , Dolas Zulelal , Silamkoti Arundutt , Gupta Anuradha , Mathur Arvind 
Published: March 2023

AbstractA carbonyldiimidazole (CDI)-promoted generation of CO from formic acid has been exploited in a reductive formylation of aryl iodides in the presence of tris(dibenzylideneacetone)dipalladium. The reaction conditions are mild with a broad functional-group tolerance that includes keto, bromo, nitrile, ester, and nitro groups. In the reaction pathway, CDI reacts with formic acid to generate a formyl imidazole that ultimately produces the CO needed for the formylation process on the activated arylpalladium complex.
Teaching Queer Concepts to Graduate Students in Communication Sciences and Disorders: Culturally Responsive Pedagogy to Foster Affirmative Clinical Practice
Authors: Robinson Gregory C. , Toliver-Smith Andrea , Stigar Lorraine V. 
Published: March 2023

AbstractThere is a growing body of literature informing pedagogical content and strategies of diversity, equity, and inclusion in the education of speech-language pathologists. However, little discussion has included content related to LGBTQ+ people, even though LGBTQ+ people exist across all racial/ethnic groups. This article seeks to fill that void and provide instructors of speech-language pathology with practical information to educate their graduate students. The discussion uses a critical epistemology and invokes theoretical models, such as Queer/Quare theory, DisCrit, the Minority Stress Model, the Ethics of Care, and Culturally Responsive Pedagogy. Information is organized according to developing graduate students' awareness, knowledge, and skills and challenges instructors to modify current course content to disrupt systemic oppression.
Differences in Sibilant Perception between Gender Expansive and Cisgender Individuals
Authors: Hope Maxwell , Lilley Jason 
Published: March 2023

AbstractAcoustic cues of voice gender influence not only how people perceive the speaker's gender (e.g., whether that person is a man, woman, or non-binary) but also how they perceive certain phonemes produced by that person. One such sociophonetic cue is the [s]/[ʃ] distinction in English; which phoneme is perceived depends on the perceived gender of the speaker. Recent research has shown that gender expansive people differ from cisgender people in their perception of voice gender and thus, this could be reflected in their categorization of sibilants. Despite this, there has been no research to date on how gender expansive people categorize sibilants. Furthermore, while voice gender expression is often discussed within a biological context (e.g., vocal folds), voice extends to those who use other communication methods. The current study fills this gap by explicitly recruiting people of all genders and asking them to perform a sibilant categorization task using synthetic voices. The results show that cisgender and gender expansive people perceive synthetic sibilants differently, especially from a “nonbinary” synthetic voice. These results have implications for developing more inclusive speech technology for gender expansive individuals, in particular for nonbinary people who use speech-generating devices.