bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tashkent, Bukhara and Khorezm republics, epidemics, and fight against them
Authors: Karomov G’. Kh  
Published: December 2022

The article concludes that the outbreak of epidemics is a major factor in the poor living conditions of the population. In human history, epidemics are a real catastrophe for the population, which is based on the fact that wars, natural conditions, coastal and famine-stricken factors are its companions. History tells about the "Justinianova chuma" spread throughout the Eastern Roman Empire, the "Black Death" epidemic in Europe, and the Spanish flu after the First World War. The population of Central Asia has been suffering from epidemics since ancient times due to hot climatic conditions and other factors. Turkistan is one of the main sources of the cholera and malaria epidemic, and in 1881 it was mentioned in New Marghilan and in 1898 in Tashkent.
Health care in Turkestan, Bukhara and Khorezm is accompanied by sanitary and epidemic work, but the difficult historical conditions, particularly political, socioeconomic problems, poor living conditions and civil war. It is also noted that droughts caused by natural disasters and, as a consequence, famine have spread epidemics. Frequent medical and sanitary measures to fight epidemics sociation units. The Turkestan ASSR Public Health Commission operated the Department of Medical Education and Sanitation, and the staff of the department was propagandizing the fight against the epidemic.
Based on the results of the study, it is concluded that in each state, the most important factor in preventing epidemics is to improve living conditions and to increase public health education.
Current status of plant resources in the Ferghana Valley and opportunities to use them
Authors: M.R. Kholikulov  
Published: December 2022

In the southern part of Kurama mountains of North Fergana near Havasay, Chadaksay and Rezaksay on the relatively large areas of medicinal plants found Eremurus sogdiana, Perovskija scrophulariifolia and other species. And Ferula tenuisecta, Prangos pabularia, Ligularia alpigena, Lagotis korolkovii, Festuca valesiaca and others meet on the Angren plateau
Age- and sex-specific differences in the association of serum osteocalcin and cardiometabolic risk factors in type 2 diabetes
Authors: Li Wei , Wang Yan , Dong Jie , Di Ruiqing , Liu Xiaojun , Liu Shengyun 
Published: December 2022

Abstract
Background: Serum osteocalcin levels are closely related to metabolic syndrome and cardiovascular disease. This study aimed to investigate the association between serum osteocalcin levels and cardiometabolic risk factors in patients with type 2 diabetes (T2D) according to age and sex.
Methods: This cross-sectional study included 1500 patients with T2D (991 men and 509 women) aged ≥18 years old. The age- and sex-specific disparities in glycemic and lipid control, as well as cardiometabolic risk factors were evaluated.
Results: The levels of serum osteocalcin were significantly higher in women aged ＞50 years old compared with women aged ≤50 years old (15.6 ± 6.5 ng/mL vs. 11.3 ± 4.5 ng/mL, p < 0.0001). However, this was lower in men aged ＞50 years old than men aged ≤50 years old (12.2 ± 4.2 ng/mL vs. 12.9 ± 4.3 ng/mL, p = 0.0081). We performed correlation analyses between serum osteocalcin and cardiometabolic parameters. Serum osteocalcin concentrations had a negative association with FBG and HbA1c levels in women and men aged ≤50 years old, but not in men aged ＞50 years old. Serum osteocalcin were negatively related to TG and positively related to HDL-C and LDL-C only in men aged ≤50 years old. In binary logistic regression analysis, serum osteocalcin levels were associated with multiple cardiovascular risk factors, as follows: being overweight/obese (odds ratio [OR], 0.944; 95% confidence interval [CI], 0.9–0.991, p = 0.02) in men aged ＞50 years old; high HbA1C and high FBG in women and men aged ≤50 years old, but not in men aged ＞50 years old; and high TG (OR, 0.905; 95% CI 0.865–0.947, p < 0.0001), metabolic syndrome (OR, 0.914; 95% CI 0.874-0.956, p < 0.0001), and low high-density lipoprotein cholesterol (OR, 0.933; 95% CI, 0.893-0.975, p = 0.002) only in men aged ≤50 years old, after adjustment for confounding factors.
Conclusions: Serum osteocalcinlevel has significant relationships with cardiometabolic risk factors and several age- and sex-related differences in patients with T2D. Decreased serum osteocalcin levels are associated with a worse cardiometabolic risk profile.
Designing TiC@GNPs reinforced pure Ti matrix composites by mechanochemical ball milling and semi-solid sintering
Authors: Zhang Zai-Yu , Yang Jian-jun , Yang Yuan , Cao Liang , Zhang Zai-Qi 
Published: December 2022

Abstract
In this work,we report on a novel in-situ TiC nanoparticles sticking to graphene nanoplatelets(TiC@GNPs)reinforced titanium matrix composites. In-situ TiC nanoparticles are produced in both mechanical ball milling and sintering processes.Ultrafine composite powder is obtained by mechanochemical ball milling from refined pure titanium powder and graphene nanoplatelets (GNPs) .A new type of TiC@GNPs/Ti composite materials with high strength and toughness and three-dimensional network distribution are made of ultrafine composite powder by various curing methods.The effects of different hot pressing parameters and reinforcing phase content on the microstructure and mechanical properties of the composites were studied. The results shown that the strength and plasticity of the ultrafine TiC@GNPs/Ti composites prepared by hot pressing sintering are obviously improved compared with the matrix. The strengthening mechanism of composites is mainly the synergistic effect of fine grain strengthening and dislocation strengthening. The ductility is due to grain refinement and in situ layered structure of TiC@GNPs particles. This layered structure is a double-scale microstructure, which is characterized by the lamellar composed of ultrafine bcc-Ti and ultrafine GNPs surrounding the fine crystal equiaxed fcc second phase TiC. The in-situ synthesis of nano-tic and nano-GNPs synergistic growth shows a criss-cross in the microstructure. The three-dimensional network distribution of GNP in titanium matrix can regulate the contradiction between strength and plasticity of titanium matrix composites.
The Smoothing Method for DNA Methylome Analysis Identifies Highly Accurate Epigenomic Signatures in Epigenome-Wide Association Studies
Authors: Oussalah Abderrahim , Trégouët David-Alexandre , Guéant Jean-Louis 
Published: December 2022

Abstract
Background: The genome-wide assessment of the DNA methylome has revolutionized our comprehension of epigenome alterations linked to complex human traits and diseases. The ability of epigenome-wide association studies (EWAS) to translate into biologically meaningful results relies on detecting epigenomic signatures with a high level of statistical certainty. However, the classical analyses of EWAS are prone to statistical inflation and bias, leading to spurious associations, particularly in case series with small sample sizes, such as those analyzing patients with rare inherited disorders.
Methods: Based on the co-methylation pattern of CpG dinucleotides within the CpG islands, we propose the smoothing method at the genome-wide level through a sliding window approach to calculate and visualize data from EWAS to decipher the most informative epigenetic alterations of EWAS with a high degree of accuracy.
Results: The smoothing method is a simple method that identifies epigenomic signatures with a high degree of certainty while controlling the risk of spurious findings outside the significant loci at a genome-wide level. We have systematically compared the smoothing method with a classical supervised approach in several EWAS settings, including two monogenic epigenetic diseases (epi-cblC and primary constitutional MLH1epimutation) and epigenetic predictors of aging. In the latter example, we showed that the smoothing method remained efficient even after applying an 80% reduction of the original sample size.
Conclusions:
The smoothing method for DNA methylation analyses is based on the biological correlate of the epigenome structure and identifies highly accurate epigenomic signatures in DNA methylation analyses. Its application to several settings of epigenome-wide analyses confirmed its usefulness for deciphering the most informative epigenomic signatures with a high degree of certainty while controlling the risk of spurious findings outside the significant loci at a genome-wide level.
Our results suggest revisiting EWAS by applying the smoothing method to already available datasets to re-analyze and potentially identify highly accurate epigenomic signatures that could translate into biologically meaningful results.
The combination treatment of methylprednisolone and growth factor-rich serum ameliorates the structural and functional changes after spinal cord injury in rat
Authors: Naseh Maryam , Mousavi Seyed Reza , Farrokhi Majid Reza , Ghaffari Mahdi Khorsand , Karimi Fatemeh , Keshavarz Somaye , Dehghanian Amir Reza 
Published: December 2022

Abstract
This study aims to evaluate the combined effect of Methylprednisolone (MP) and growth factor-rich serum (GFRS) on structural and functional recovery in rats following spinal cord injury (SCI). Male Sprague-Dawley rats were randomly assigned to five groups: 1- sham group (laminectomy); 2- SCI group (the spinal cord clip compression model); 3- SCI-MP group (30 mg/kg MP was administrated intraperitoneally (IP) immediately after SCI); 4- SCI-GFRS group (GFRS (200 µl, IP) was administrated for six consecutive days); and 5- SCI-MP + GFRS group (the rats received MP (30 mg/kg, IP) immediately after SCI, and GFRS (200 µl, IP) for six consecutive days). Motor function was assessed weekly using the Basso, Beattie, and Bresnahan (BBB) scale. After four weeks, we conducted the rotarod test, then removed and prepared the spinal cords (including the epicenter of injury) for stereological and histological estimation (n = 6 for each group), and biochemical assays (n = 5 for each group). The results showed that MP and GFRS combining treatment enhanced functional recovery, which was associated with a decrement in lesion volume, increased spared white and gray matter volume, reduced neuronal loss, as well as decreased necrosis and hemorrhage after SCI. Moreover, administration of MP and GFRS inhibited lipid peroxidation (MDA content), and increased antioxidant enzymes including glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) after rat SCI. Our study suggests that the combination treatment of MP and GFRS may ameliorate the structure and functional changes following SCI by reducing oxidative stress, and increasing the level of antioxidants enzymes.
Application of Opioid-Free General Anesthesia for Gynecological Laparoscopic Surgery Under ERAS Protocol: A Non-inferiority Randomized Controlled Trial
Authors: Chen Liang , He Wensheng , Liu Xue , Lv Fahui , Li Yuanhai 
Published: December 2022

Abstract
Background
Enhanced recovery after surgery (ERAS) is now widely used in various surgical fields including gynecological laparoscopic surgery, but the advantages of opioid-free anesthesia (OFA) in gynecological laparoscopic surgery under ERAS protocol are inexact.
Aims
This study aims to assess the effectiveness and feasibility of OFA technique versus traditional opioid-based anesthesia (OA) technique in gynecological laparoscopic surgery under ERAS.
Methods
Adult female patients aged 18 ~ 65 years old undergoing gynecological laparoscopic surgery were randomly divided into OFA group (Group OFA, n = 39) with esketamine and dexmedetomidine or OA group (Group OA, n = 38) with sufentanil and remifentanil. All patients adopted ERAS protocol. The primary outcome was the area under the curve (AUC) of Visual Analogue Scale (VAS) scores (AUCVAS) postoperatively. Secondary outcomes included intraoperative hemodynamic variables, awakening and orientation recovery times, number of postoperative rescue analgesia required, incidence of postoperative nausea and vomiting (PONV) and Pittsburgh Sleep Quality Index (PSQI) perioperatively.
Results
AUCVAS was (Group OFA, 16.72 ± 2.50) vs (Group OA, 15.99 ± 2.72) (p = 0.223). No difference was found in the number of rescue analgesia required(p = 0.352). There were no between-group differences in mean arterial pressure (MAP) and heart rate (HR) (p = 0.211 and 0.659, respectively) except MAP at time of surgical incision immediately [(Group OFA, 84.38 ± 11.08) vs. (Group OA, 79.00 ± 8.92), p = 0.022]. Times of awakening and orientation recovery in group OFA (14.54 ± 4.22 and 20.69 ± 4.92, respectively) were both longer than which in group OA (12.63 ± 3.59 and 18.45 ± 4.08, respectively) (p = 0.036 and 0.033, respectively). The incidence of PONV in group OFA (10.1%) was lower than that in group OA (28.9%) significantly (p = 0.027). The postoperative PSQI was lower than the preoperative one in group OFA (p = 0.013).
Conclusion
In gynecological laparoscopic surgery under ERAS protocol, OFA technique is non-inferior to OA technique in analgesic effect and intraoperative anesthesia stability. Although awakening and orientation recovery times were prolonged compared to OA, OFA had lower incidence of PONV and improved postoperative sleep quality.
Trial registration:
ChiCTR2100052761, 05/11/2021.
Dynamic Goal Tracking for Differential Drive Robot using Deep Reinforcement Learning
Authors: Shahid Mahrukh , Khan Semab Neimat , Khawaja Fahad Iqbal , Ali Sara , Ayaz Yasar 
Published: December 2022

Abstract
To ensure the steady navigation for robot stable controls are one of the basic requirements. Control values selection is highly environment dependent. To ensure reusability of control parameter system needs to generalize over the environment. Adding adaptability in robots to perform effectively in the environments with no prior knowledge reinforcement leaning is a promising approach. However, tuning hyper parameters and attaining correlation between state space and reward function to train a stable reinforcement learning agent is a challenge. In this paper we designed a continuous reward function to minimizing the sparsity and stabilizes the policy convergence, to attain control generalization for differential drive robot. We Implemented Twin Delayed Deep Deterministic Policy Gradient on Open-AI Gym Race Car. System was trained to achieve smart primitive control policy, moving forward in the direction of goal by maintaining an appropriate distance from walls to avoid collisions. Resulting policy was tested on unseen environments including dynamic goal environment, boundary free environment and continuous path environment on which it outperformed Deep Deterministic Policy Gradient.
Coastal rocky slopes instability analysis and landslide frequency-area distribution alongside the road network in west Mediterranean context (Northern of Morocco)
Authors: Obda Oussama , Kharim Younes El , Obda Ilias , Ahniche Mohamed , Kouffi Abdelaaziz El 
Published: December 2022

Abstract

The Mediterranean coasts are known for their tourist attractiveness due to its richness in fishing resources and beach resorts as well as landscapes at the level of different ecosystems (forests, rocky and sandy beaches). The construction of the Mediterranean coastal road (RN16), which aims to enhance the tourist value of these resources and to improve access to this coastal region, has triggered an almost radical modification in the development process of this area, where the risks are increasing because of the multiplication of the challenges and the hazards due to the instability of its slopes. These events are mainly the result of marine erosion, the involvement of geological, geomorphological, climatic factors and also anthropic parameters with a strong littoralisation. The study area is characterized by active tectonics translated by the presence of faulting sets affecting the rock mass. The aim of this study is to assess the characteristics of the rock mass and its stability, and to anticipate landslide occurrence frequency with a particular size in a specified region with a certain rock mass quality as well. The methodology followed in this work consists of the elaboration of a complete inventory of landslides, the fracturation analysis and the rock mass engineering conducted to evaluate the stability of the slopes and the statistical analysis of the landslide size distribution. The combination of these two approaches has allowed us to assess qualitatively and quantitatively the landslide hazard on coastal rocky fractured areas.
Consensus clinical management guidelines for Acid Sphingomyelinase Deficiency (Niemann-Pick disease types A, B and A/B)
Authors: Geberhiwot Tarekegn , Wasserstein Melissa , Wanninayake Subadra , Bolton Shaun Christopher , Dardis Andrea , Lehman Anna , Lidove Oliver , Dawson Charlotte , Giugliani Roberto , Imrie Jackie , Hopkin Justin , Green James , Corbeira Daniel de Vicente , Madathil Shyam , Mengel Eugen , Ezgu Fatih , Pettazzoni Magali , Sjouke Barbara , Hollak Carla , Vanier Marie T , McGovern Margaret , Schuchman Edward 
Published: December 2022

Abstract
Background: Acid sphingomyelinase deficiency (ASMD) is a rare autosomal recessive disorder caused by mutations in SMPD1 gene. This rarity contributes to misdiagnosis, delayed diagnosis and barriers to good care. There is no published national or international guideline for diagnosis and management of patients with ASMD. For these reasons, we at INPDR have developed a clinical guideline that define standard of care for ASMD patients
Methods: The information contained in these guidelines was obtained through a systematic review of the literature and the experiences of the authors in their care of patients with ASMD. We adopted the Appraisal of Guidelines for Research & Evaluation (AGREE II) system as method of choice for the guideline development process.
Results: The clinical spectrum of ASMD, although a continuum, varies substantially with subtypes ranging from a fatal infantile neurovisceral disorder to an adult-onset chronic visceral disease. We made 39 conclusive statements and scored them according to level of evidence, strengths of recommendations and expert opinions. In addition, this guideline has identified gaps in the knowledge that must be filled by future research.
Conclusion: This guideline can inform care providers, care funders, patients and their carers about best clinical practice and lead to a step change in the quality of care for patients with ASMD.
Prevalence of Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis
Authors: Song Xiaowei , Cong Shengnan , Zhang Ming , Gan Xiaokui , Meng Fan , Huang Baosheng 
Published: December 2022

Abstract
Background
As a common complication after aneurysmal subarachnoid hemorrhage, the prevalence of pituitary dysfunction ranges widely at the global level and has not been synthesized by meta-analysis for a few years. Updated estimates of the prevalence of pituitary dysfunction after aneurysmal subarachnoid hemorrhage are urgently needed to improve recognition and attention from medical.
Methods
We comprehensively searched four literature databases including Scopus, Embase, Web of Science and PubMed, and performed a random-effects meta-analysis for the search results. Heterogeneity in the prevalence estimates was analyzed by subgroup analysis in terms of WHO region and type of pituitary dysfunction.
Results
27 studies with 1848 subjects were included in this study. The pooled prevalence of pituitary dysfunction in the acute phase was 49.6% (95% CI, 32.4%-66.8%), and decreased in the chronic phase to 30.4% (95% CI, 21.4%-39.4%). Among the hormonal deficiencies, growth hormone dysfunction was the most prevalent in the acute phase with 36.0% (95% CI, 21.0%-51.0%), and in the chronic phase was hypoadrenalism accounting for 21.0% (95% CI, 12.0%-29.0%). While referring to the WHO region, the prevalence of pituitary dysfunction in the acute phase was the highest in SEARO, up to 81.0% (95%CI, 77.0%-86.0%), while the EURO with the highest prevalence of pituitary dysfunction in the chronic phase, was only 33.0% (95%CI, 24.0%-43.0%). Moreover, single pituitary hormone dysfunction occurred more frequently than that of multiple regardless of in the acute or chronic phase.
Conclusions
In up to 49.6%, patients with aneurysmal subarachnoid hemorrhage may be complicated with pituitary dysfunction, which deserved more attention. Although the prevalence decreased over time, early detection and early treatment were more beneficial for the quality of life of patients. However, the number of existing studies on PD after aSAH is limited. Therefore, more studies based on larger populations and countries are necessary to provide early warning.
Roles of Iron in Chemoresistance of Multiple Myeloma Depends on the Interaction with Bone Marrow Stromal Cells
Authors: Jiang Hongmei , Wang Sheng , Wang Jingya , Cheng Hao , Li Xin , Xie Ying , Wang Yixuan , Li Qian , Hu Meilin , Peng Ziyi , Wang Mengqi , Wang Jing , Xie Yangyang , Wang Yafei , Swaminathan Sundararaman , Bergsagel P. Leif , Liu zhiqiang 
Published: December 2022

Abstract
Bone marrow (BM) niche plays critical roles in promoting progression and chemoresistance of multiple myeloma (MM), but the iron metabolism bridging the malignant plasma cells and BM stromal cells (BMSCs) has not been well elucidated. Using in vitro and in vivo models of interaction of MM and BMSCs, we identified that iron level was augmented due to the elevated expression of transferrin in MM cells, and the accumulation of iron desensitized MM cells to proteasome inhibitors (PIs) treatment and promoted productions of cholesterol and lanosterol. Simultaneously, direct contact with BMSCs remarkably upregulated the protein level of GPX4, a ROS eraser, to obviate ferroptosis in MM cells. Mechanistic studies revealed that CD40/CD40 ligand (CD40L) signaling promoted the expressions of transferrin and SUMO-specific protease 3 (SENP3), and SENP3 stabilized GPX4 protein via deSUMOylation modification. GPX4 inhibitor induced ferroptosis was cell-cell contact dependent, since blocking CD40/CD40L interaction, or depletion of Cd40l in BMSCs from Cd40lfl/fl;Prx1Cre/+ mice, eliminated the anti-MM efficacy of RSL3 in the Vk*MYC mouse model of myeloma, but not in the patient-derived xenografts (PDX) model. Our study deciphers mechanism of iron metabolism in regulating MM chemoresistance, and clarifies the therapeutic potential of non-apoptosis strategies in managing refractory or relapsed MM patients.