bluuebunny/crossref_metadata_2025_split huggingface dataset:
She said this might be God’s way of taking care of us. Family involvement in human trafficking
Authors: Adeyinka Sarah , Lietaert Ine , Derluyn Ilse 
Published: July 2023

Purpose
This paper aims to explore the role of family members in human trafficking and how their roles impact and are perceived by their children and wards.

Design/methodology/approach
This paper uses data collected through a longitudinal, cross-country study. The study was conducted among 31 female, Nigerian victims of trafficking in Italy.

Findings
The authors argue that family members play important, howbeit diverse roles across space and time, in the different stages of the trafficking process, echoing a relational approach of their geographies.

Originality/value
This paper discusses the under-researched role of how family members may (wilfully or unknowingly) facilitate and aid the trafficking of their dependents and the consequences of their involvement on their children and wards.
The effect of social media exposure, environmental concern and consumer habits in green consumption intention
Authors: Yanyan Zhang , Pek Chuen-Khee , Cham Tat-Huei 
Published: July 2023

PurposeThis study aims to look into consumers' green consumption intention by incorporating social media exposure, environmental concern and habit into theory of planned behavior (TPB) in the context of China advocating green consumption.Design/methodology/approachBased on the data collected from online survey, this study use partial least squares structural equation modeling (PLS-SEM) to analysis the measurement model and structure model.FindingsThe results show attitude, social media exposure, environmental concern and subjective norms are important determinants of consumers' intention to purchase green products.Originality/valueThis study explores the new associations between the major constructs of the TPB model in green consumption. This study also expanded the TPB model by adding three extra factors, namely social media exposure, habit and environmental concern. In addition, this study attempts to bridge the gap between attitude and intention from a new perspective by using social media exposure as a moderating variable.
Towards a sustainable future: developing a cybersecurity framework for manufacturing
Authors: Alqudhaibi Adel , Deshpande Sourav , Jagtap Sandeep , Salonitis Konstantinos 
Published: July 2023

PurposeThis study aims to propose a cybersecurity framework that prioritizes sustainability in the manufacturing sector by identifying necessary resources and capabilities for effective cybersecurity management. The proposed framework aims to enhance resource protection and safeguard data confidentiality, integrity and accessibility, provide proactive steps for predicting cyber threats and highlight the importance of educating employees at all levels of the organization.Design/methodology/approachA thorough review of existing literature and analysis was conducted to develop the proposed cybersecurity framework. Several frameworks, including the NIST cybersecurity framework, were reviewed to identify the necessary skills and resources required to combat cyber threats and keep businesses sustainable.FindingsThe proposed framework includes proactive steps, such as predicting cyber threats, and emphasizes the importance of educating employees and raising awareness at all levels of the organization. Resilience is also emphasized, which refers to an organization's ability to recover and continue operations following a cyberattack. Implementing this framework may require a significant budget and time investment, and small organizations may face limitations in applying all aspects of the framework.Originality/valueThis study proposes a cybersecurity framework that prioritizes sustainability in the manufacturing sector, which provides added protection for organizations. The framework's key functions can be adopted partially or fully, making it suitable for organizations of varying sizes. Future research can focus on addressing the framework's limitations and shortcomings to further reduce cyber risks for sustainable manufacturing, establishing the scale of an industry based on its economy and extending the framework to non-manufacturing businesses.
Early serum ammonia variation in critically ill patients with cirrhosis: A multicentre cohort study
Authors: Cardoso Filipe S. , Kim Minjee , Pereira Rui , Bagulho Luís , Fidalgo Pedro , Pawlowski Anna , Wunderink Richard , Germano Nuno , Bagshaw Sean M. , Abraldes Juan G. , Karvellas Constantine J. 
Published: July 2023

SummaryBackgroundSerum ammonia variation in critically ill patients with cirrhosis has been poorly studied.AimTo describe and assess the impact of serum ammonia variation in these patients' outcomes.MethodsWe studied patients ≥18 years old admitted to the intensive care units (ICUs) at University of Alberta Hospital (Edmonton, Canada) and Curry Cabral Hospital (Lisbon, Portugal; derivation cohort, n = 492) and Northwestern University Hospital (Chicago, USA; validation cohort, n = 600) between January 2010 and December 2021. Primary exposure was ICU days 1–3 serum ammonia. Primary endpoint was all‐cause hospital mortality.ResultsIn the derivation cohort, 330 (67.1%) patients were male and median (IQR) age was 57 (50–63) years. On ICU day 1, median ammonia was higher in patients with grade 3/4 hepatic encephalopathy (HE) than those with grade 2 HE or grade 0/1 HE (112 vs. 88 vs. 77 μmoL/L, respectively; p < 0.001). Furthermore, medium ammonia was higher in hospital non‐survivors than survivors (99 vs. 86 μmol/L; p < 0.030). Following adjustment for significant confounders (age, HE, vasopressor use and renal replacement therapy delivery), higher ICU day 2 ammonia was independently associated with higher hospital mortality (adjusted OR per each 10 μmoL/L increment [95% CI] = 1.11 [1.01–1.21]; p = 0.024). In the validation cohort, this model with serial ammonia (ICU days 1 and 3) predicted hospital mortality with reasonably good discrimination (c‐statistic = 0.73) and calibration (R2 = 0.19 and Brier score = 0.17).ConclusionsAmong patients with cirrhosis in the ICU, early serum ammonia variation was independently associated with hospital mortality. In this context, serial serum ammonia may have prognostic value.
microRNA‐651‐5p affects the proliferation, migration, and invasion of lung cancer cells by regulating Calmodulin 2 expression
Authors: Lang Yaoguo , Kong Xianglong , Liu Benkun , Jin Xiangyuan , Chen Lantao , Xu Shidong 
Published: July 2023

AbstractObjectiveLung cancer is prevalent worldwide and a leading contributor to tumor death. This research intends to explore the molecular mechanism of the microRNA‐651‐5p (miR‐651‐5p)/Calmodulin 2 (CALM2) axis in the proliferation, migration, and invasion of lung cancer cells.MethodsLung cancer tissues and para‐cancerous tissues were collected. The expression levels of miR‐651‐5p and CALM2 in lung cancer tissues and cells were tested, and the connection between miR‐651‐5p expression and clinicopathological characteristics of lung cancer patients was further analyzed. The binding sites between miR‐651‐5p and CALM2 were analyzed and validated. Lung cancer cell proliferation, migration, invasion, and apoptosis were examined.ResultsmiR‐651‐5p was lowly expressed in lung cancer tissues and cells. miR‐651‐5p expression had no correlation with patients' age and gender but had a correlation with patients' tumor size, TNM stage, and lymph node metastasis. Overexpression of miR‐651‐5p repressed proliferative, migratory, and invasive behaviors of lung cancer cells. miR‐651‐5p targeted and negatively regulated CALM2 expression, and CALM2 reversed the inhibiting effects of miR‐651‐5p on lung cancer cell malignant behaviors, including proliferation, migration, and invasion.ConclusionThis study expounds that miR‐651‐5p affects the proliferation, migration, and invasion of lung cancer cells by regulating CALM2 expression.
Breaching, Bridging, and Bonding: Interweaving Pathways of Social‐Symbolic Work in a Flanked Healthcare Movement
Authors: Geiger Susi , Stendahl Emma 
Published: July 2023

AbstractThis article explores how heterogeneous and distributed forms of social‐symbolic work combine over time to yield synergistic relationships that precipitate institutional change. We study a collective effort by patient activists to change the technological and regulatory standards of Type 1 diabetes care. We offer contributions to radical flank theory by conceptualizing radical and moderate flanks as dynamic and overlapping pathways of action rather than fixed actor positions, and we show how a medial ‘bonding’ pathway can provide important social glue to connect the radical and moderate flanks. While in our case the material and discursive ‘hacking’ work in the breaching pathway disrupted institutions, triggered technology innovation, and created momentum for change, material and relational ‘bridging’ embedded these efforts into existing institutional structures and longer‐term innovation trajectories. Values and amplification work in the bonding pathway served to keep the two other pathways aligned over time. By addressing how a complex social problem – patient‐centric innovation – may be affected through heterogeneous social‐symbolic work that leads to institutional accommodation, our study holds considerable policy and societal relevance.
Study on Thermal–Hydraulic Characteristics of Novel Channels for Printed Circuit Heat Exchanger Using Supercritical CO2
Authors: Yang He , Li Jinduo , Wei Huimin , Du Xiaoze , Wu Hongwei 
Published: July 2023

Abstract
Two new types of printed circuit heat exchanger (PCHE) channels are proposed based on the typical airfoil fin PCHE channel proposed in literatures (standard channel) to further improve the thermal–hydraulic performances of airfoil fin PCHE channel. The small shuttle fins and oval fins are employed between the adjacent two airfoil fins of two novel channels, respectively. Using supercritical CO2 as the working fluid, the thermal–hydraulic performances and enhancement mechanisms of the novel channels are numerically investigated. The results show that the channel with shuttle fins has the best comprehensive performance. The Nusselt number of the channel with shuttle fins is 6.7–26% larger, and the f-factor is 8.3–18.6% larger than that of the standard channel under the selected conditions, which leads to a 3–19.1% increase in the PEC (comprehensive performance evaluation criteria). The Nusselt number of the channel with oval fins is 9–27.3% larger, and the f-factor is 26.6–43.4% larger than that of the standard channel, which leads to a 1–15.3% increase in the PEC. The applications of small fins between the adjacent two fins can effectively reduce the low-velocity region area and enhance the local disturbance, thereby effectively improving the thermal–hydraulic performance. The enhancement mechanism of the novel fin PCHE channel structure can be well explained by the principle of field synergy. It can be found that the synergies of the temperature gradient field and the velocity field in two novel channels are significantly improved.
S‑Glutathionylation and S‑Nitrosylation as Modulators of Redox-Dependent Processes in Cancer Cell
Authors: Kalinina Elena V. , Novichkova Maria D. 
Published: July 2023

Abstract
Development of oxidative/nitrosative stress associated with the activation of oncogenic pathways results from the increase in the generation of reactive oxygen and nitrogen species (ROS/RNS) in tumor cells, where they can have a dual effect. At high concentrations, ROS/RNS cause cell death and limit tumor growth at certain phases of its development, while their low amounts promote oxidative/nitrosative modifications of key redox-dependent residues in regulatory proteins. The reversibility of such modifications as S‑glutathionylation and S‑nitrosylation that proceed through the electrophilic attack of ROS/RNS on nucleophilic Cys residues ensures the redox-dependent switch in the activity of signaling proteins, as well as the ability of these compounds to control cell proliferation and programmed cell death. The content of S‑glutathionylated and S‑nitrosylated proteins is controlled by the balance between S‑glutathionylation/deglutathionylation and S‑nitrosylation/denitrosylation, respectively, and depends on the cellular redox status. The extent of S‑glutathionylation and S‑nitrosylation of protein targets and their ratio largely determine the status and direction of signaling pathways in cancer cells. The review discusses the features of S‑glutathionylation and S‑nitrosylation reactions and systems that control them in cancer cells, as well as their relationship with redox-dependent processes and tumor growth.
Process modelling of NHS cardiovascular waiting lists in response to the COVID-19 pandemic
Authors: Catsis Salvador , Champneys Alan R , Hoyle Rebecca , Currie Christine , Enright Jessica , Cheema Katherine , Woodall Mike , Angelini Gianni , Nadarajah Ramesh , Gale Chris , Gibbison Ben 
Published: July 2023

ObjectiveTo model the referral, diagnostic and treatment pathway for cardiovascular disease (CVD) in the English National Health Service (NHS) to provide commissioners and managers with a methodology to optimise patient flow and reduce waiting lists.Study designA systems dynamics approach modelling the CVD healthcare system in England. The model is designed to capture current and predict future states of waiting lists.SettingRoutinely collected, publicly available data streams of primary and secondary care, sourced from NHS Digital, NHS England, the Office of National Statistics and StatsWales.Data collection and extraction methodsThe data used to train and validate the model were routinely collected and publicly available data. It was extracted and implemented in the model using the PySD package in python.ResultsNHS cardiovascular waiting lists in England have increased by over 40% compared with pre- COVID-19 levels. The rise in waiting lists was primarily due to restrictions in referrals from primary care, creating a bottleneck postpandemic. Predictive models show increasing point capacities within the system may paradoxically worsen downstream flow. While there is no simple rate-limiting step, the intervention that would most improve patient flow would be to increase consultant outpatient appointments.ConclusionsThe increase in NHS CVD waiting lists in England can be captured using a systems dynamics approach, as can the future state of waiting lists in the presence of further shocks/interventions. It is important for those planning services to use such a systems-oriented approach because the feed-forward and feedback nature of patient flow through referral, diagnostics and treatment leads to counterintuitive effects of interventions designed to reduce waiting lists.
Language outcomes at 4 years of linguistically diverse children born very preterm: an Australian retrospective single-centre study
Authors: Tinoco Mendoza Giannina , Stack Jacqueline , Abdel-Latif Mohamed E , Raman Shanti , Garg Pankaj 
Published: July 2023

BackgroundVery preterm children are at increased risk of language delays. Concerns have been raised about the utility of standardised English language tools to diagnose language delay in linguistically diverse children. Our study investigated the incidence of language delay at 4 years in linguistically diverse very preterm children.MethodsVery preterm children born in South Western Sydney, Australia, between 2012 and 2016, were assessed with the Clinical Evaluation of Language Fundamentals Preschool-2 (CELF-P2) tool at 4 years of age. We sought to determine the incidence of language delay in this cohort using language scores from the CELF-P2 assessment tool, and explore potential predictors associated with language delay.ResultsOne hundred and sixty very preterm children attended the 4-year assessment out of the included 270 long-term survivors. At 4 years, 76 (52%) very preterm children had language delay diagnosed using the CELF-P2 assessment tool. Children who preferred a language other than English had lower average core language scores on the CELF-P2 assessment tool (75.1±14.4) compared with children that preferred English (86.5±17.9); p=0.002. Very preterm children growing up in households that preferenced a language other than English and those who were born from multiple births had higher odds of language delay at 4 years (AOR 10.30 (95% CI 2.82 to 38.28); p<0.001 and AOR 2.93 (95% CI 1.20 to 7.14); p=0.018, respectively). Assessing these children using an English language tool may have affected language scores at 4 years.ConclusionsIn this metropolitan setting, very preterm children from linguistically diverse backgrounds were found to be vulnerable to language delays at 4 years. Further large-scale studies evaluating the language outcomes of linguistically diverse preterm children with more culturally appropriate tools are warranted. We question the utility of standardised English language tools to assess language outcomes of linguistically diverse populations.
Factors influencing blood pressure control in patients with atrial fibrillation and hypertension in Australian primary care
Authors: Trivedi Ritu , Marschner Simone , Shaw Tim , Min Haeri , Yue Jason , Kazi Samia , Nguyen Tu Ng , Laranjo Liliana , Chow Clara K 
Published: July 2023

ObjectiveThis study explored factors that may influence blood pressure (BP) control in patients with atrial fibrillation (AF) with hypertension.MethodsCross-sectional retrospective analysis of the MedicineInsight database which includes de-identified electronic health records from general practices (GPs) across Australia. BP control was assessed in patients with diagnosed AF and hypertension (controlled BP defined as <140/90 mm Hg). We explored BP control, factors influencing BP control and likelihood of receiving guideline-recommended treatment.Results34 815 patients with AF and hypertension were included; mean age was 76.9 (10.2 SD) years and 46.2% were female. 38.0% had uncontrolled BP. Women (OR 0.72; 95% CI 0.68, 0.76; p<0.001) and adults ≥75 years (OR 0.78; 95% CI 0.70, 0.86; p<0.001) were less likely to have controlled BP. Greater continuity of care (CoC; that is, visits with the same clinician) and having frequent GP visits were associated with higher odds of controlled BP (model 1: CoC, OR 1.29; 95% CI 1.20, 1.40, p<0.001; GP visits, OR 1.71; 95% CI 1.58, 1.85, p<0.001) and a greater likelihood of being prescribed ≥2 types of BP-lowering medicines (model 2: CoC, OR 1.12; 95% CI 1.03, 1.23; p=0.011; GP visits, OR 1.80; 95% CI 1.63, 1.98; p<0.001).ConclusionsUncontrolled BP was more likely in women and adults ≥75 years. Patients who had frequent GP visits with the same clinician were more likely to have BP controlled and receive guideline-recommended antihypertensive treatment. This suggests that targeting these primary care factors could potentially improve BP control and subsequently reduce stroke risk in patients with AF.
Effect of valproic acid upon skeletal muscle subjected to prolonged tourniquet application
Authors: Moritz Robert , Mangum Lee , Voelker Chet , Garcia Gerardo , Wenke Joseph 
Published: July 2023

BackgroundValproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries. This study was designed to investigate the ability of VPA to mitigate ischemia–reperfusion injury produced by prolonged tourniquet application to an extremity.MethodsThe ischemia–reperfusion model in anesthetized rats was established using hemorrhage and a 3-hour tourniquet application. VPA was administered intravenously prior to tourniquet wear and removal. Ischemia–reperfusion injury was evaluated by investigating pathway signaling, immune modulation of cytokine release, remote organ injury, and skeletal muscle function during convalescence.ResultsWe found that VPA sustained Protein kinase B (Akt) phosphorylation and Insulin-like growth factor signaling and modulated the systemic release of interleukin (IL)-1β, tumor necrosis factor alpha, and IL-6 after 2 hours of limb reperfusion. Additionally, VPA attenuated a loss in glomerular filtration rate at 3 days after injury. Histological and functional evaluation of extremity skeletal muscle at 3, 7, and 21 days after injury, however, demonstrated no significant differences in myocytic degeneration, necrotic formation, and maximal isometric tetanic torque.ConclusionsOur results demonstrate that VPA sustains early prosurvival cell signaling, reduces the inflammatory response, and improves renal function in a hemorrhage with prolonged ischemia and reperfusion model. However, these do not translate into meaningful preservation in limb function when applied as a pharmaceutical augmentation to tourniquet wear.Level of evidenceIV.
Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature
Authors: Grobe Connie C. , Reho John J. , Brown-Williams Daeleon , Ziegler Alisha A. , Mathieu Natalia M. , Lawton Samuel B.R. , Fekete Eva M. , Brozoski Daniel T. , Wackman Kelsey K. , Burnett Colin M.L. , Nakagawa Pablo , Sigmund Curt D. , Segar Jeffrey L. , Grobe Justin L. 
Published: July 2023

BACKGROUND:
Mice prefer warmer environments than humans. For this reason, behavioral and physiological thermoregulatory responses are engaged by mice in response to a standard room temperature of 22 to 24 °C. Autonomic mechanisms mediating thermoregulatory responses overlap with mechanisms activated in hypertension, and, therefore, we hypothesized that housing at thermoneutral temperatures (TNs; 30 °C) would modify the cardiometabolic effects of deoxycorticosterone acetate (DOCA)–salt in mice.

METHODS:
The effects of DOCA-salt treatment upon ingestive behaviors, energy expenditure, blood pressure, heart rate (HR), and core temperature were assessed in C57BL/6J mice housed at room temperature or TN.

RESULTS:
Housing at TN reduced food intake, energy expenditure, blood pressure, and HR and attenuated HR responses to acute autonomic blockade by chlorisondamine. At room temperature, DOCA-salt caused expected increases in fluid intake, sodium retention in osmotically inactive pools, blood pressure, core temperature, and also caused expected decreases in fat-free mass, total body water, and HR. At TN, the effects of DOCA-salt upon fluid intake, fat gains, hydration, and core temperature were exaggerated, but effects on energy expenditure and HR were blunted. Effects of DOCA-salt upon blood pressure were similar for 3 weeks and exaggerated by TN housing in the fourth week.

CONCLUSIONS:
Ambient temperature robustly influences behavioral and physiological functions in mice, including metabolic and cardiovascular phenotype development in response to DOCA-salt treatment. Studying cardiometabolic responses of mice at optimal ambient temperatures promises to improve the translational relevance of rodent models.
Talking Hats: What Documents and Textiles Can Tell Us about Each Other
Authors: Liebrenz Boris 
Published: July 2023

Abstract
This article seeks to demonstrate that a believed Seljuq hat from Iran is in fact a Fatimid hat from Egypt. For the first time, it uses an analysis of the paper documents that used to line this once splendid samite piece and asks about the archival logic of their reuse. Beyond this narrow question of origin, the analysis illustrates a methodological challenge for textile historians who often have to operate without additional documentary material and sufficient information on provenance. Finally, an attempt is made to contextualize what appears to have been a tradition of sartorial representation when limited textual and pictorial sources have survived.