bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation Effect of 2-β-hydroxy Manoyl Oxide Isolated from Sideritis
perfoliata on Carbonic Anhydrase Isoenzymes I and II
Authors: Aksit Huseyin , Rasul Azhar , Adem Şevki , Güler Çağlar , Demirtas İbrahim 
Published: June 2023

Background:
Sideritis species were used for the treatment of mental disorders such as
Alzheimer’s and dementia traditionally in Turkey. Several in vivo studies report that the mid-polar
extract of Sideritis species can develop the brain functions of mice. 2-β-hydroxy manoyl oxide, isolated
from ethyl acetate extract of Sideritis perfoliata, was assayed in vitro and in silico on human
erythrocytes CA I and CA II. The compound was found to be an activator on two isoenzymes. It has
been reported that activators of carbonic anhydrases may be used as a novel approach to treating
disorders such as Alzheimer’s and age-related diseases. This study aimed to investigate the activity
effect of 2-β-hydroxy manoyl oxide in vitro and in silico on human erythrocytes CA I and CA II
(hCA I and hCA II) and to elucidate its pharmacokinetic and physicochemical characteristics.

Methods:
The test compound was isolated from ethyl acetate extract of Sideritis perfoliata using
chromatographic techniques and identified with spectroscopic evidence. Carbonic anhydrase activities
were assayed using CO2 substrates. Docking studies were carried out with Molegro Virtual
Docker. The compound underwent ADME-Tox prediction by using AdmetSAR and SwissADME
software.

Results:
2-β-hydroxy manoyl oxide was found to increase the hCA-l and hCAII activity with
AC50 values 9 and 19 μM, respectively. These results were further confirmed in silico molecular
modeling. It showed favorable pharmacokinetic and physicochemical characteristics as a new
drug candidate.

Conclusion:
These findings demonstrated that 2-β-hydroxy manoyl oxide activated the hCA-l
and hCA II. These results provide a novel and alternative activator for the carbonic anhydrase and
confirm the traditional usage of the Sideritis perfoliata.
Mental Health: Pandemics, Epidemics and Tau Protein
Authors: Barakat Ghinwa M. , Assi Ghaith , El Khoury Noura B. 
Published: June 2023

Background:
It is well established that a wide range of psychological disorders are influenced by the way people live, with lifestyle-related factors playing a substantial role. During the past decade, the effects of major disasters on mental health have drawn a lot of attention.

Aim:
In this review, we compare clinical studies reporting a link between COVID-19 and other pandemics and mental health. Importantly, we also shed light on Tau protein and neurotransmitters as neurobiological factors that might explain this link.

Methods:
A thorough PubMed search was done to gather and summarize published data on the COVID-19 pandemic’s effect on mental health. Additionally, these studies were compared to previous research published on PubMed, triggering other pandemic and epidemic impacts on mental health.

Results:
The COVID-19 epidemic has had the biggest impact on raising awareness about mental health. Moreover, the past century has seen an increase in the frequency of disease outbreaks like MERS-CoV, Ebola, and Influenza, which all had an impact on mental health. However, the exact role of these epidemics on mental health and brain functions is poorly understood.

Conclusion:
Future research on the underlying pathways may yield essential information for the treatment and prevention of prospective mental diseases in light of the ongoing decline in mental health during the past 10 years.
Tik Tok media pengembangan karakter melalui kreativitas tari kreasi Dayak
Authors: Asri Gita Kinanthi Purnama , Suwarjiya Suwarjiya , Aulia Nur 
Published: June 2023

Penelitian ini mendeskripsikan nilai karakter pendidikan yang muncul melalui kreativitas tari kreasi Dayak dengan pemanfaatan aplikasi Tik-tok sebagai media pengembangan karakter siswa ekstrakurikuler di SMPN 1 Kapuas Murung. Metode penelitian yang digunakan adalah eksperimen dengan pendekatan kuantitatif dan kualitatif. Pengumpulan data menggunakan teknik wawancara, observasi, dokumentasi, tes dan studi pustaka. Penelitian ini menghasilkan 2 tari kreasi Dayak berjudul tari Ular Naga dan tari Inting melalui metode ATM(amati, tiru dan modifikasi), hasilnya diupload di aplikasi Tik Tok pada 12 Juni 2021.(2) Terdapat 12 nilai karakter yang muncul yaitu karakter cinta tanah air, kreatif, disiplin, mandiri, jujur, kerja keras, demokratif, rasa ingin tahu, bersahabat/komunikatif, menghargai prestasi, peduli sosial, dan tanggung jawab.(3)Aplikasi Tik Tok sebagai aplikasi yang digemari kalangan peserta didik, mampu mendukung pembelajaran kreativitas tari secara efektif, sebagai ruang ekspresi dan apresiasi. Kata Kunci: tik tok, kreativitas tari, pendidikan karakter, tari kreasi, dayak TIK TOK CHARACTER DEVELOPMENT MEDIATHROUGH THE CREATIVITY OF DAYAK CREATIVE DANCE AbstractThe purpose of this research is to describe the value of the educational character that emerges through the creativity of Dayak dance creations using Tik-tok application for extracurricular students at SMPN 1 Kapuas Murung. This research is an experimental research with a qualitative and qualitative approaches. Collecting data using interview techniques, observation, documentation, tests and literature study. This research produced 2 works entitled Ular Naga dance and Inting dance through the ATM method (observe, imitate and modify as a result of dance creativity, uploaded via Tik Tok on June 12, 2021. (2) There are 9 character values that appear, namely the character of love of the homeland, creative, disciplined, independent, hard working, democratize, curiosity, friendly/communicative, and responsibility. (3) The Tik Tok application as an application that is popular with students, is able to support learning dance creativity effectively, as a space for expression and appreciation. Keywords: tik tok, character development media, creativity dance, Dayak
Kajian pertunjukan musik “Thungka” dalam masyarakat Bawean Gresik (Tinjauan etnomusikologi)
Authors: Almanda Hafi Hilmiah , Yuwana Setya , Yanuartuti Setyo 
Published: June 2023

Penelitian ini menemukan kajian etnomusikologi pada alat musik thungka, karena peneliti ingin mengetahui segala sesuatu yang terdapat dalam alat musik thangka, baik itu berupa aspek fungsi, musikal, instrumental dan sosial budaya musik tradisional thungka. Dalam penelitian ini metode yang digunakan yaitu metode kualitatif. Fungsi musik Thungka pada dasarnya sebagai alat untuk penumbuk padi dalam acara musim panen disetiap tahun akan tetapi sekarang menjadi sebagai media pertunjukan seni tradisional, acara pernikahan sampai keacara penyambutan tamu turis ke Bawean. Alat musik Thungka ini merupakan alat musik tradisional yang tergolong bertangga nada tetratonik yaitu memiliki empat tangganada. Thungka, bahan dasarnya dari ronjengan sampai Alu’ terdiri dari kayu berjenis Jati. Lirik yang dimainkan dalam pertunjukan Thungka memaparkan tentang kehidupan masyarakat Bawean. Kata kunci: Etnomusikolgi, Musik Thungka, Bawean Study of "Thungka" music performance in Bawean Gresik community(An ethnomusicology review) AbstractThis study found an ethnomusicological study on the thungka musical instrument, because the researcher wanted to know everything contained in the thangka musical instrument, whether it was in the form of functional, musical, instrumental and socio-cultural aspects of thungka traditional music. In this study the method used is a qualitative method. The function of Thungka music is basically as a tool for pounding rice in the harvest season every year but now it has become a medium for traditional art performances, weddings to welcoming tourist guests to Bawean. This Thungka musical instrument is a traditional musical instrument that is classified as a tetratonic scale, which has four scales. Thungka, the basic ingredients from ronjengan to pestle are teak wood. The lyrics played in the Thungka show describe the life of the Bawean people.Keywords: Ethnomusicology, Thungka Music, Bawean
The value of tolerance in learning Nusantara dance
Authors: Sofa Tresna Maya 
Published: June 2023

Tolerance is an attitude that must be owned by every individual as part of the diversity of the world community, especially as citizens of Indonesia with various ethnicities, cultures, languages, and customs. Archipelago Dance Learning is one of the subjects that can instill the value of tolerance in students. In the cognitive domain, students learn various dances, both dance as physical, ideas, and systems. Meanwhile, in affection, students learn to appreciate, appreciate, and love various types of dance in Indonesia. In the psychomotor domain, students learn to practice the movements of the Nusantara Dance. This paper will examine the role of learning Indonesian dance towards the tolerance attitude of students through a hermeneutic approach. This study uses a qualitative descriptive method with a Gadamer hermeneutic approach to gain the broadest possible understanding of the learning of Nusantara Dance in instilling tolerance values in students. The results obtained from this study indicate that based on the results of analysis and interpretation, the results show that learning Indonesian dances not only provides theoretical knowledge about the diversity of traditional dances in Indonesia but also becomes a medium for instilling tolerance values in students. Understanding various cultures and understanding the various customs, norms, and values of certain ethnic groups or ethnic groups.Keywords: tolerance, multiculture, learning archipelago dance Nilai toleransi pada pembelajaran Tari NusantaraAbstrakToleransi merupakan salah satu sikap yang harus dimiliki oleh setiap individu sebagai bagian dari keberagaman masyarakat dunia, terlebih sebagai warga negara Indonesia yang beraneka ragam suku bangsa, budaya, bahasa, dan adat istiadat. Pembelajaran Tari Nusantara merupakan salah satu mata pelajaran yang mampu menanamkan nilai toleransi bagi peserta didik. Pada ranah kognitif peserta didik mempelajari bebagai tari yang ada baik tari sebagai fisik, ide maupun sistem. Sementara ranah afeksi peserta didik belajar mnegapresiasi, menghargai , dan mencintai berbagai macam tari di Indonesia. Pada ranah psikomotorik peserta didik belajar mempraktikan gerak-gerak Tari Nusantara. Tulisan ini akan mengkaji peranan pembelajaran Tari Nusantara terhadap sikap toleransi peserta didik melalui pendekatan hermeneutik. Penelitian ini menggunakan metode deskripsi kualitatif dengan pendekatan hermeneutic Gadamer untuk mendapatkan pemahaman seluas mungkin mengenai pembelajaran Tari Nusantara dalam menanamkan nilai toleransi pada peserta didik. Adapun hasil yang diperoleh dari penelitian ini menunjukan bahwa Berdasarkan hasil analisis dan penafsiran diperoleh hasil bahwa pembelajaran tari nusantara tidak hanya memberikan pengetahuan secara teori mengenai keberagaman tari tradisi yang ada di Indonesia tetapi juga menjadi media dalam menanamkan nilai toleransi bagi peserta didik. Memahami ragam budaya dan turut memahami beragam adat istiadat, norma, dan nilai pada kelompok etnis atau suku bangsa tertentu.Kata Kunci: toleransi, multikultural, pembelajaran tari nusantara
Novel Software for High-level Virological Testing: Self-Designed Immersive Virtual Reality Training Approach
Authors: Tsai Huey-Pin , Lin Che-Wei , Lin Ying-Jun , Yeh Chun-Sheng , Shan Yan-Shen 
Published: June 2023

Background
To ensure the timely diagnosis of emerging infectious diseases, high-tech molecular biotechnology is often used to detect pathogens and has gradually become the gold standard for virological testing. However, beginners and students are often unable to practice their skills due to the higher costs associated with high-level virological testing, the increasing complexity of the equipment, and the limited number of specimens from patients. Therefore, a new training program is necessary to increase training and reduce the risk of test failure.

Objective
The aim of the study is to (1) develop and implement a virtual reality (VR) software for simulated and interactive high-level virological testing that can be applied in clinical practice and skills building or training settings and (2) evaluate the VR simulation’s effectiveness on reaction, learning, and behavior of the students (trainees).

Methods
Viral nucleic acid tests on a BD MAX instrument were selected for our VR project because it is a high-tech automatic detection system. There was cooperation between teachers of medical technology and biomedical engineering. Medical technology teachers were responsible for designing the lesson plan, and the biomedical engineering personnel developed the VR software. We designed a novel VR teaching software to simulate cognitive learning via various procedure scenarios and interactive models. The VR software contains 2D VR “cognitive test and learning” lessons and 3D VR “practical skills training” lessons. We evaluated students’ learning effectiveness pre- and posttraining and then recorded their behavior patterns when answering questions, performing repeated exercises, and engaging in clinical practice.

Results
The results showed that the use of the VR software met participants’ needs and enhanced their interest in learning. The average posttraining scores of participants exposed to 2D and 3D VR training were significantly higher than participants who were exposed solely to traditional demonstration teaching (P<.001). Behavioral assessments of students pre- and posttraining showed that students exposed to VR-based training to acquire relevant knowledge of advanced virological testing exhibited significantly improved knowledge of specific items posttraining (P<.01). A higher participant score led to fewer attempts when responding to each item in a matching task. Thus, VR can enhance students’ understanding of difficult topics.

Conclusions
The VR program designed for this study can reduce the costs associated with virological testing training, thus, increasing their accessibility for students and beginners. It can also reduce the risk of viral infections particularly during disease outbreaks (eg, the COVID-19 pandemic) and also enhance students’ learning motivation to strengthen their practical skills.
Atención a la dislexia con recursos digitales: una revisión de la literatura
Authors: Raposo Rivas Manuela , González Regal Antía 
Published: June 2023

Este artículo tiene como objetivo caracterizar la producción científica del período 2015-2021, sobre el uso de los recursos digitales para la atención de la dislexia en edades comprendidas entre los 6 y los 12 años, identificando el enfoque del estudio y el soporte que poseen los recursos digitales utilizados en la intervención con dislexia. La matriz de datos está constituida por artículos científicos ubicados en Dialnet, ERIC, Scopus y ScienceDirect. Tras una identificación inicial de 447 artículos, fueron seleccionados 27 con base en criterios como el idioma, acceso al texto completo y el ámbito educativo. Se utilizó como instrumento de análisis una escala de estimación con ítems relativos a aspectos formales y de contenido. Los resultados muestran que dicha producción científica se centra, fundamentalmente, en revisiones bibliográficas o en el diseño de recursos y la intervención con ellos en el aula, evidenciando que su uso tiene efectos positivos.
Pelayanan Publik Melalui E-Klampid dalam Mewujudkan Administrasi Kependudukan Berbasis Good Governace di Kota Surabaya
Authors: Pratama Aldi , Sukristyanto Agus , Hariyoko Yusuf 
Published: June 2023

Pelayanan publik ialah bentuk kegiatan yang diupayakan untuk membantu keperluan pelayanan yang merujuk pada peraturan perundang-undangan bagi warga negara dan penduduk baik berupa jasa, barang, atau pelayanan administratif yang telah disediakan oleh pihak penyelenggara pelayanan publik. Pemerintah wajib melakukan pelayanan publik secara optimal yang berdasar pada undang undang nomor 25 tahun 2009 pasal 1 ayat 1 yang menjelaskan bahwa pelayanan publik ialah bentuk kegiatan yang dilakukan pemerintah untuk memenuhi hak-hak dasar warga negaranya, oleh sebab itu pemberian pelayanan publik dituntut harus dilaksanakan secara optimal. Upaya bentuk pelayanan publik yang diadakan oleh pemerintah salah satunya yaitu dalam bidang administrasi kependudukan.Mengenai pelayanan Dispendukcapil Kota Surabaya adalah bidang administrasi kependudukan. Sebagai instansi pemerintah yang bertugas memberikan segala pelayanan administrasi kependudukan khususnya untuk wilayah Surabaya. Dalam pengembangan smart city menggunakan e-governance ini tidak lain tidak bukan pemerintah kota surabaya khususnya dispendukcapil kota surabaya memberikan tujuan pelayanan publik yang lebih baik dan prima serta memberikan kemudahan dalam berinteraksi dengan masyarakat. Adanya pembaharuan sangat dibutuhkan yang dimaksudkan untuk memperbaiki bahkan meningkatkan kualitas, efisiensi dan efektivitas penyelenggaraan pelayanan publik. Melalui pembaharuan tersebut maka akan tercipta sistem, metode, serta teknologi yang dapat menurunkan biaya, mempersingkat waktu layanan, memangkas birokrasi. Penelitian ini bertujuan untuk mengetahui penerapan pelayanan e-klampid dalam mewujudkan good governance di kota Surabaya dan mengetahui faktor penghambat dan pendorong terhadap pelayanan aplikasi e-klampid secara online. metode penelitian yang diterapkan dalam penelitian ini adalah metode kualitatif. Hasil penelitian ini merujuk berdasarkan empat indikator good governance yaitu partisipasi masyarakat, transparansi, supremasi hukum, efektifitas dan efisiensi.
THE CONTINUITY AND CHANGE OF DIYAT AS AN ALTERNATIVE TO ISLAMIC CRIMINAL SANCTIONS IN UNDHANG-UNDHANG BANTĚN DURING THE 17th – 18th CENTURIES
Authors: Ishom Muhammad 
Published: June 2023

This research emphasizes the shift from the archaic trend of applying corporal punishment to other types of humane punishment in pre-modern periods. This phenomenon occurred not only in the Western world but also in the Eastern and Islamic worlds. One of them was the criminal law contained in the Banten Law (UUB), which was implemented in the Banten sultanate between the 18th and 19th centuries. Islamic criminal law in the form of qişaş and hudûd sanctions was no longer applied in Banten, but was replaced with more humane fines or diyat sanctions. Was the criminal law reform in the sultanate of Banten influenced by developments in Western law? One of the explanations given in the UUB was that the sultan of Banten employed the view of the Maliki school of thought, which allowed the ruler the right to impose takzir on criminal cases that had been resolved by Islamic law sanctions. The legal case for using diyať sanctions instead of qišaš and hudûd punishments was more substantial if takzir punishment was employed. This study used data in the form of UUB manuscript (single text) with the code number LOr 5598. The legal texts in UUB were analyzed using a legal social history approach. This study concludes that the application of law in UUB has dogmatic reasons for Islamic criminal law and the interests of siyasať syar'iyať.
The Impact of the Companions' Approach on Ensuring the Quality of Thought among Muslims: Musannaf Ibn Abi Shaybah as a Model
Authors: Al-Hammami Taleb Ibn Ahmad 
Published: June 2023

The study aims to explain the Companions' approach to achieving intellectual security and the quality of sound thought. Also, it clarifies the error of extremists and their violation of the Companions' approach. The study followed the inductive, deductive, and descriptive approaches to achieve the study objective. The study concluded that the Companions' approach is a true benchmark by which the moderation or deviation of thought is measured. Also, the greatest immunization of thought deviation is to adhere to the Book and the Sunnah according to the Companions' understanding. This study is distinguished from previous studies in that it collected the impact of the Companions from Musannaf Ibn Abi Shaybah in achieving intellectual security. It set standards for the quality of thought among the Companions to serve as a beacon for scholars and preachers in protecting Muslim societies from thought deviations and refuting misleading suspicions to preserve the integrity of future generations and their ideas.
Living Qur’an, Gender, and Sibaliparriq, in Mandar, Indonesia: Cultural Construction in the Perspective of Islamic Law
Authors: Yakub Bahruddin Umar , Husain Husain , Nurdin Abidin , Nurhayati Nurhayati , Hidayatulloh Miftah Khilmi 
Published: June 2023

Cultural construction creates an unequal understanding of gender between men and women. This construction causes women to live in marginal and unfair conditions. This article aims to examine the concept of sibaliparriq in the construction of Mandar culture as associated with the living Qur'an. This study is a qualitative study using the Living Al-Qur'an approach and is analyzed using gender theory and the sociology of Islamic law. Data was collected through interviews, observation, and a literature review. This research finds that sibaliparriq, in the concept and application of Mandar, is a woman's willingness to help her husband in the household. Sibaliparriq is interpreted as affection (siasayanni), caring (siamanaoang pa'mai), brotherhood (palluluareang), and sincerity (sukku' mattulung). Sibaliparriq is related to the concept of gender in the Qur'an, and there is no contradiction between them, so that the cultural construction is also equal and balanced. Both position women in an honorable and dignified manner; they are seen as Allah's creatures who live to help each other; the difference between the two is only in piety (taqwa). Sibaliparriq is an application of the living Qur'an which is practiced in the life of the Mandar people, namely helping each other (ta’awūn) for good in household life. Sociologically, this has implications for Islamic and customary laws that are well integrated into society.
Evaluation of Internal Audit Role as a Governance, Risk and Compliance Partner, Trusted Advisor and Value Driver to Implement Strategy
Authors: Nasal Tandid , Gani Lindawati 
Published: June 2023

This study aims to evaluate the alignment of the scope of internal audit activities with the strategy of Indonesia’s Social Health Insurance Provider (BPJS Kesehatan). The perception of the added value provided by the internal audit is often described as hazy and enigmatic. Therefore, Eulerich and Lenz (2020) defined the internal audit role into three scopes: Governance, risk and compliance (GRC) partner, trusted advisor and value driver. This qualitative research uses a case study method by collecting internal organisational documents, questionnaire surveys and interviews. The results show that BPJS Kesehatan’s internal audit can act as both a GRC partner and a trusted advisor. However, its internal audit activity is not prepared and aligned with the implementation of the organisation’s strategy. The internal audit function is nevertheless moving towards aspects in which it may add more value to the success of the organisation’s strategy.