bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health of migrants and other vulnerable populations across Asian countries: Build Forward Better beyond the COVID-19 pandemic
Authors: Iwamoto Azusa , Fujita Masami , Luong Dang Quang , Anh Jongsoh , Chiu Betty Ya-Wen , Choi Jaewook , Chiou Hung-Yi , Hayashi Reiko , Kobayashi Jun 
Published: September 2023

AbstractGlobal migration has been increasing since before the COVID-19 pandemic. The pandemic has clearly shown a lack of preparedness for the next public health emergency when it comes to vulnerable populations including migrants. To include the issues of migration and health in the current global health agenda, it is important to establish/strengthen a network for collaboration among various stakeholders from both the migrant-sending and host countries of migrants especially in the Asian-Pacific region. As the initial step for networking in Asia, in March 2023, a hybrid style international symposium was held in Japan and agreed on a goal and five pillars: surveillance and monitoring, risk communications, community engagement, access to health and social protection services, and supportive environments. Considering the transition of context from the COVID-19 crisis to ‘Build Forward Better’, through the Asian network, we will envisage the better world, where vulnerable populations including migrants will not be left behind from health security.
Biomarkers of sarcopenia: an unmet need
Authors: El-Sebaie Mona , Elwakil Walaa 
Published: September 2023

Abstract
Background
Sarcopenia is a syndrome characterized by a progressive decline in muscle mass and strength, with subsequent deterioration of functional performance and increased morbidity and mortality. Its emergence may be associated with disorders that are not limited to the elderly. The multifactorial nature of sarcopenia is a major barrier to diagnosis. Several risk factors contribute to the development of sarcopenia, including age, gender, and amount of physical activity. Additionally, the pathophysiology of sarcopenia involves inflammatory conditions, endocrinal dysfunction, and metabolic alterations. Several studies have proposed numerous molecules that may be linked to the pathogenesis of sarcopenia and could be useful in the future; however, there is an unmet need to discover a sensitive, reliable, and cost-effective biomarker of muscle aging.

Main text
The objective of this research is to highlight different biomarkers of sarcopenia that reflect its multifactorial pathophysiology. A narrative review was carried out through a series of literature searches in the database MEDLINE/PubMed focusing on sarcopenia biomarkers. The following search terms were used: “sarcopenia,” “osteosarcopenia,” “muscle ageing,” “muscle failure,” “sarcopenic obesity,” “weakness,” “biomarkers,” “frailty,” “comorbidity,” “functional disability,” and “inflamm-aging.” The studies were observational and peer-reviewed. They were all carried out at a referral center, hospital, or in the community. The articles chosen all contained information about sarcopenia. Case reports and articles that did not assess people's muscle aging and sarcopenia were not considered.

Conclusion
Despite the availability of numerous functional, imaging, and biological sarcopenia markers, the inherent limitations of the assessment tools make it difficult to objectively measure the various sarcopenia domains. A valid and reliable biomarker of sarcopenia has yet to be identified. The identification of “gold standard” evaluation techniques that should be systematically used is also impacted by the variability of the populations to be assessed. In this context, the establishment of an international consensus adopting a multi-biomarker approach may be of utmost importance to tackle the different aspects of this multifactorial health-related problem.
Potential neuropsychological mechanism involved in the transition from suicide ideation to action – a resting-state fMRI study implicating the insula
Authors: Fang Shulin , Law Samuel F. , Ji Xinlei , Liu Qinyu , Zhang Panwen , Zhong Runqing , Li Huanhuan , Wang Xiaosheng , Yao Shuqiao , Wang Xiang 
Published: September 2023

Abstract

Background
Understanding the neural mechanism underlying the transition from suicidal ideation to action is crucial but remains unclear. To explore this mechanism, we combined resting-state functional connectivity (rsFC) and computational modeling to investigate differences between those who attempted suicide(SA) and those who hold only high levels of suicidal ideation(HSI).

Methods
A total of 120 MDD patients were categorized into SA group (n=47) and HSI group (n=73). All participants completed a resting-state functional MRI scan, with three subregions of the insula and the dorsal anterior cingulate cortex (dACC) being chosen as the region of interest (ROI) in seed-to-voxel analyses. Additionally, 86 participants completed the balloon analogue risk task (BART), and a five-parameter Bayesian modeling of BART was estimated.

Results
In the SA group, the FC between the ventral anterior insula (vAI) and the superior/middle frontal gyrus (vAI-SFG, vAI-MFG), as well as the FC between posterior insula (pI) and MFG (pI-MFG), were lower than those in HSI group. The correlation analysis showed a negative correlation between the FC of vAI-SFG and psychological pain avoidance in SA group, whereas a positive correlation in HSI group. Furthermore, the FC of vAI-MFG displayed a negative correlation with loss aversion in SA group, while a positive correlation was found with psychological pain avoidance in HSI group.

Conclusion
In current study, two distinct neural mechanisms were identified in the insula which involving in the progression from suicidal ideation to action. Dysfunction in vAI FCs may gradually stabilize as individuals experience heightened psychological pain, and a shift from positive to negative correlation patterns of vAI-MFC may indicate a transition from state to trait impairment. Additionally, the dysfunction in PI FC may lead to a lowered threshold for suicide by blunting the perception of physical harm.
Evaluating patient safety research performance in Arab world countries: Changing trends and reflections
Authors: Zubairi Nadeem , Butt Nadeem , Malik Ahmad , Gazzaz Zohair 
Published: September 2023

Background and Objective: Patient safety is a major concern in health care. Research is an important tool to minimize preventable errors. Research performance and trends evaluation need to be identified for future guidance. Our objective was to evaluate the research performance in Arab World countries related to patient safety so that real picture is available to all stake holders for future application
Methods: This was a descriptive exploratory study carried at King Abdulaziz University Jeddah, using Bibliometric analyses on Web of Science extracted data, exploring the research publications related to Patient Safety from the Arab World in last two decades (2001-2020). Digital resources were used. Data collected was further explored to see the trends.
Results: Only 2% of total worldwide publications on Patient Safety were from Arab World. A positive trend, however, has emerged since 2015. Out of 5940 documents identified, only 383 had single authorship. Egypt and Saudi Arab were the major contributors. Other countries had less or even zero publications. Researchers are coordinating with others in Western countries to enhance the research productivity. Cairo University with 734 publications had most affiliations. Publications on safety culture and medication safety were frequent. Hospital Acquired Infections and error reporting had limited research.
Conclusion: Researches on patient safety in the Arab World are not sufficient. Countries other than Egypt and Saudi Arabia also need to contribute more frequently. Critical problems, like Hospital Acquired Infections, should have regular research from all countries to assist those treating patients and those making health related policies.
doi: https://doi.org/10.12669/pjms.39.6.7514
How to cite this: Zubairi NA, Butt NS, Malik AA, Gazzaz ZJ. Evaluating patient safety research performance in Arab world countries: Changing trends and reflections. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.7514
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A prediction model of risk factors of poor wound healing after craniocerebral surgery
Authors: Zhong Chunlian , Lu Wei , Xie Wenzhong , Jiao Wei 
Published: September 2023

Objective: To explore the independent risk factors of poor wound healing after craniocerebral surgery, and to generate a risk prediction model.
Methods: A single-center retrospective observational analysis of 160 patients who underwent craniocerebral surgery in The 904th Hospital of the Joint Logistics Support Force of the PLA from February 2018 to February 2021 was carried out. Patients were divided into Group-A (n=70) and Group-B (n=90) according to postoperative wound healing outcome. Logistic regression was used to analyze the independent risk factors, and a nomogram prediction model was constructed using R software. The receiver operating characteristic (ROC) curve was used to test the predictive ability of the model, and the fitting effect was verified by Hosmer Lemeshow.
Results: The duration of operation, surgical site infection, diabetes mellitus, and the time of intubation in Group-B were significantly lower than Group-A (P<0.05). Serum albumin (ALB) and hemoglobin (HGB) in Group-B were significantly higher than those in Group-A (P<0.05). Logistic regression analysis showed that long operation duration, surgical site infection, duration of drainage tube, ALB <35g/L, and abnormal HGB were independent risk factors for poor wound healing (P<0.05). The area under the ROC curve (AUC) predicted by the model was 0.932, 95%CI (0.862~1.000). The Hosmer-Lemeshow goodness of fit test showed that the expected probability calculated by the model matched the actual probability (P>0.05).
Conclusions: Long operation duration, surgical site infection, duration of drainage tube, ALB <35g/L, and abnormal HGB were risk factors for poor wound healing. The nomograph model based on these factors showed good discrimination, calibration, and clinical effectiveness in predicting poor wound healing.
doi: https://doi.org/10.12669/pjms.39.6.7963
How to cite this: Zhong C, Lu W, Xie W, Jiao W. A prediction model of risk factors of poor wound healing after craniocerebral surgery. Pak J Med Sci. 2023;39(6):---------. doi: https://doi.org/10.12669/pjms.39.6.7963
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Quantum data communication protection with the quantum permutation pad block cipher in counter mode and Clifford operators
Authors: Barbeau Michel 
Published: September 2023

Background: This article integrates two cryptographic schemes for quantum data protection. The result achieves authentification, confidentiality, integrity, and replay protection. The authentication, integrity, and replay aspects leverage quantum Clifford operators. Confidentiality of quantum messages is achieved using the quantum permutation pad (QPP) cryptographic scheme. Methods: Clifford operators and the QPP are combined into a block cipher in counter mode. A shared secret is used to seed a random number generator for the arbitrary selection of Clifford operators and quantum permutations to produce a signature field and perform encryption. An encryption and signature algorithm and a decryption and authentication algorithm are specified to protect quantum messages. Results: A symmetric key block cipher with authentication is described. The plain text is signed with a sequence of randomly selected Clifford operators. The signed plaintext is encrypted with a sequence of randomly selected permutations. The algorithms are analyzed. As a function of the values selected for the security parameters, there is an unavoidable risk of collision. The probability of block collision is modelled versus the number of blocks encrypted, for block sizes two, three, four, and five qubits. Conclusions: The scheme is practical but does not achieve perfect indistinguishability because of the risk of message collision. This is normal and unavoidable when fixed-size fields are assumed to make a scheme practical. The model can be used to determine the values of the security parameters and the lifetime of session keys to mitigate the risk of information leakage according to the needs of the scheme’s users. The session key can be renewed when a tolerable maximum number of messages has been sent.
The Conceptual Flaws of Decentralized Automated Market Making
Authors: Park Andreas 
Published: September 2023

Decentralized exchanges (DEXs) are an essential component of the nascent decentralized finance (DeFi) ecosystem. The most common DEXs are so-called automated market makers (AMMs): smart contracts that pool liquidity and process trades as atomic swaps of tokens. AMMs price transactions with a deterministic liquidity invariance rule that only uses the AMM’s token deposits as inputs and that has no precedent in traditional finance. Yet, in the context of transparent and open blockchain operations, any liquidity invariance pricing function allows so-called sandwich attacks (akin to front running) that increase the cost of trading and threaten the long-term viability of the DeFi ecosystem. Invariance pricing is also not regret free. Linear pricing rules have similar problems except for uniform pricing, which has regret-free prices and limits sandwich attack profits but which invites excessive order splitting. Comparing trading costs using a model of liquidity provision, constant product pricing is often cheaper except when the variance of the underlying asset is small or when the order is large. This paper was accepted by Will Cong, Special Section of Management Science: Blockchains and Crypto Economics. Funding: A. Park received financial support from the Global Risk Institute and the Social Sciences and Humanities Research Council of Canada [Grant 435-2017-0647]. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2021.02802 .
Government Loan Guarantees, Market Liquidity, and Lending Standards
Authors: Ahnert Toni , Kuncl Martin 
Published: September 2023

We study third-party loan guarantees in a model in which lenders can screen and sell loans before maturity when in need of liquidity. Loan guarantees improve market liquidity, reduce lending standards, and can have a positive overall welfare effect. Guarantees improve the average quality of nonguaranteed loans traded and thus, the market liquidity of these loans because of selection. This positive pecuniary externality provides a rationale for guarantee subsidies. Our results contribute to a debate about reforming government-sponsored mortgage guarantees by Fannie Mae and Freddie Mac, suggesting that the excessively high subsidies to these guarantees should be reduced but not completely eliminated. This paper was accepted by Kay Giesecke, finance.
The role of the clinical nurse specialist in stoma care: a scoping review
Authors: Bird Andrew , Burch Jennie , Thorpe Gabrielle 
Published: September 2023

Aim: Rapidly evolving roles in nursing require exploration and description. This review aims to examine the role of the clinical nurse specialist (CNS) in stoma care from the UK perspective. Design: A scoping review was undertaken using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Data were synthesised using content analysis to derive meaning units and themes. Data sources: Three electronic databases were used to conduct the search: Embase, AMED and Ovid Medline. Additional sources identified through the reference lists of included studies and guidelines were also included. Methods: Two reviewers undertook the search for articles that described the role of the stoma care CNS in the UK. Any disagreements were to be resolved through discussion. Results: Seven papers met the eligibility criteria. Analysis resulted in 184 unique meaning units. Meaning units were grouped into themes reflecting the four pillars of advanced practice: advanced clinical practice; leadership; facilitation of education and learning; and evidence, research and development. The fewest meaning units were attributed to the evidence theme (n=13) and the most related to advanced clinical practice (n=107) such as having specialist knowledge and skills to manage complications. Conclusion: The stoma care CNS role reflects the four pillars of advanced practice. These practitioners are valuable, carrying out a complex role that involves high-level, specialist decision-making skills. The results from this scoping review could be useful in service development; they will be used to inform the Association of Stoma Care Nurses UK modified Delphi consensus to examine the views of stoma care CNS practitioners.
Positive effects of cold atmospheric plasma on pH in wounds: a pilot study
Authors: Hämmerle Gilbert , Ascher Stefanie , Gebhardt Lisa 
Published: September 2023

Objective: Cold atmospheric plasma (CAP) is a promising new option for the treatment of hard-to-heal (chronic) wounds. The aim of this study was to observe the effect of CAP on wound pH, as a correlation between the pH of a wound and its healing tendency has been established in the literature. Method: Patients with hard-to-heal wounds were treated with CAP in addition to standard treatment. Treatment was performed with the aid of a small, mobile plasma device, which was used for one minute at a time during dressing changes. The pH value, wound size, and other parameters, such as exudate and signs of infection, were recorded for each treatment. Results: A total of 10 patients took part in the study. During the observation period, there was a significant reduction in pH from a markedly alkaline pH of 9.6 to a neutral pH of 7. This was accompanied by a marked reduction in wound size by an average of 76% with seven applications of CAP within 28 days. The evaluation of tissue granulation, exudate and signs of infection showed a positive trend. Conclusion: The number of patients in the present study is not sufficient to prove the relationship between the pH value of the wound and the treatment with CAP. However, there are clear indications that the positive effects of CAP on wound healing, which are recognised in several publications, are also due to its influence on wound pH value.
The role of cells and signal pathways in subchondral bone in osteoarthritis
Authors: Luo Pan , Yuan Qi-ling , Yang Mingyi , Wan Xianjie , Xu Peng 
Published: September 2023

Osteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA, the changes in subchondral bone (SB) are not only secondary manifestations of OA, but also an active part of the disease, and are closely associated with the severity of OA. In different stages of OA, there were microstructural changes in SB. Osteocytes, osteoblasts, and osteoclasts in SB are important in the pathogenesis of OA. The signal transduction mechanism in SB is necessary to maintain the balance of a stable phenotype, extracellular matrix (ECM) synthesis, and bone remodelling between articular cartilage and SB. An imbalance in signal transduction can lead to reduced cartilage quality and SB thickening, which leads to the progression of OA. By understanding changes in SB in OA, researchers are exploring drugs that can regulate these changes, which will help to provide new ideas for the treatment of OA.Cite this article: Bone Joint Res 2023;12(9):536–545.
Discovery of habitat preferences and community structure of Echinoderms in Kri, Raja Ampat, Indonesia
Authors: SIBURIAN RIMA HERLINA SETIAWATI , TAPILATU JULIA ROSEMARY , TAPILATU MARYROSE EASTER 
Published: September 2023

Abstract. Siburian RHS, Tapilatu JR, Tapilatu ME. 2023. Discovery of habitat preferences and community structure of Echinoderms in Kri, Raja Ampat, Indonesia. Biodiversitas 24: 3968-3976. Raja Ampat, located in Papua, Indonesia, is home to one of the most diverse coral reef ecosystems and is a component of the Coral Triangle. The coral in Raja Ampat is still considered to be in good health. Although the marine fauna in Raja Ampat is pristine and diverse, there have still only been a few studies in this region. The scientific research on the Echinoderms in Raja Ampat is limited, particularly as a primary input for data research. In this study, we present Echinoderm's habitat and community structure in the Kri coastal area at Mansuar Island based on the data collected at field sampling. From January to February 2023, data were collected intensively during morning and afternoon low tide for three repetitions each, at 5-10 m depths. We conducted morphological species identification. Asteroidea, Holothuroidea, Echinoidea, and Crinoidea were found to be the four major classes of Echinodermata that dominated the sampling area, with a total of 20 species and 180 individuals. Each Echinodermata species has its preferred Kri coastal habitat based on its food supply, unique behavior, and body structure. In addition, the result indicates that this region has a moderate diversity level, with low dominance and moderate to high uniformity. This research provides new information on the ecology of Echinoderms in eastern Indonesia, particularly in Raja Ampat.
Vitamin D deficiency and SARS‑CoV‑2 infection: A retrospective case–Control study with big-data analysis covering March 2020 to March 2021
Authors: Neira Álvarez Marta , Navarro Jiménez Gema , Anguita Sánchez Noemi , del Mar Bermejo Olano Mª , Queipo Rocio , Benavent Núñez María , Parralejo Jimenez Alejandro , López Yepes Guillermo , Sáez Nieto Carmen 
Published: September 2023

Background
Vitamin D may have immunomodulatory functions, and might therefore play a role in the pathogenesis of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, no conclusive evidence exists regarding its impact on the prevalence of this infection, the associated course of disease, or prognosis.

Objective
To study the association between SARS-CoV-2 infection and vitamin D deficiency in patients attending a tertiary university hospital, and to examine the clinical course of infection and prognosis for these patients.

Methods
This non-interventional, retrospective study, which involved big-data analysis and employed artificial intelligence to capture data from free text in the electronic health records of patients diagnosed with SARS-CoV-2, was undertaken at a tertiary university hospital in Madrid, Spain, between March 2020 and March 2021. The variables recorded were vitamin D deficiency, sociodemographic and clinical characteristics, course of disease, and prognosis.

Results
Of the 143,157 patients analysed, 36,261 had SARS-CoV-2 infection (25.33%) during the study period, among whom 2,588 (7.14%) had a vitamin D deficiency. Among these latter patients, women (OR 1.45 [95%CI 1.33–1.57]), adults over 80 years of age (OR 2.63 [95%CI 2.38–2.91]), people living in nursing homes (OR 2.88 [95%CI 2.95–3.45]), and patients with walking dependence (OR 3.45 [95%CI 2.85–4.26]) appeared in higher proportion. After adjusting for confounding factors, a higher proportion of subjects with SARS-CoV-2 plus vitamin D deficiency required hospitalisation (OR 1.38 [95%CI 1.26–1.51]), and had a longer mean hospital stay (3.94 compared to 2.19 days in those with normal levels; P = 0.02).

Conclusion
A low serum 25(OH) vitamin D concentration in patients with SARS-CoV-2 infection is significantly associated with a greater risk of hospitalisation and a longer hospital stay. Among such patients, higher proportions of institutionalised and dependent people over 80 years of age were detected.