bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis
Authors: Liu Haibo , Luo Shicheng , Sha Xiaofeng , Chen Zhiping , Yang Dongdong 
Published: September 2023

Abstract
Cancer-associated fibroblasts (CAFs) play critical roles in the tumor microenvironment and exert tumor-promoting or tumor-retarding effects on cancer development. Astragaloside IV has been suggested to rescue the pathological impact of CAFs in gastric cancer. This study aimed to investigate the potential mechanism of astragaloside IV in the regulation of CAF pathological functions in gastric cancer development. Homeobox A6 (HOXA6), and Zinc Finger and BTB Domain Containing 12 (ZBTB12) are highly expressed in gastric CAFs compared with normal fibroblasts (NFs) based on the GSE62740 dataset. We found that astragaloside IV-stimulated CAFs suppressed cell growth, migration, and invasiveness of gastric cancer cells. HOXA6 and ZBTB12 were downregulated after astragaloside IV treatment in CAFs. Further analysis revealed that HOXA6 or ZBTB12 knockdown in CAFs also exerted inhibitory effects on the malignant phenotypes of gastric cells. Additionally, HOXA6 or ZBTB12 overexpression in CAFs enhanced gastric cancer cell malignancy, which was reversed after astragaloside IV treatment. Moreover, based on the hTFtarget database, ZBTB12 is a target gene that may be transcriptionally regulated by HOXA6. The binding between HOXA6 and ZBTB12 promoter in 293T cells and CAFs was further confirmed. HOXA6 silencing also induced the downregulation of ZBTB12 mRNA and protein in CAFs. Astragaloside IV was demonstrated to regulate the expression of ZBTB12 by mediating the transcriptional activity of HOXA6. Our findings shed light on the therapeutic value of astragaloside IV for gastric cancer.
Rosuvastatin effects on the HDL proteome in hyperlipidemic patients
Authors: Vavlukis Ana , Mladenovska Kristina , Davalieva Katarina , Vavlukis Marija , Dimovski Aleksandar 
Published: September 2023

Abstract
The advancements in proteomics have provided a better understanding of the functionality of apolipoproteins and lipoprotein-associated proteins, with the HDL lipoprotein fraction being the most studied. The focus of this study was to evaluate the HDL proteome in dyslipidemic subjects without an established cardiovascular disease, as well as to test whether rosuvastatin treatment alters the HDL proteome. Patients with primary hypercholesterolemia or mixed dyslipidemia were assigned to 20 mg/day rosuvastatin and blood samples were drawn at study entry and after 12 weeks of treatment. A label-free LC-MS/MS protein profiling was conducted, coupled with bioinformatics analysis. Sixty-nine HDL proteins were identified, belonging to four main biological function clusters: lipid transport and metabolism; platelet activation, degranulation, and aggregation, wound response and wound healing; immune response; inflammatory and acute phase response. Five HDL proteins showed statistically significant differences in the abundance (Anova ≤ 0.05), before and after rosuvastatin treatment. Platelet factor 4 variant (PF4V1), Pregnancy-specific beta-1-glycoprotein 2 (PSG2), Profilin-1 (PFN1) and Keratin type II cytoskeletal 2 epidermal (KRT2) showed decreased expressions, while Integrin alpha-IIb (ITGA2B) showed an increased expression after treatment with rosuvastatin. The ELISA validation of PFN1 segregated the subjects into responders and non-responders, as PFN1 levels after rosuvastatin were shown to mostly depend on the subjects’ inflammatory phenotype. Findings from this study introduce novel insights into the HDL proteome and statin pleiotropism.
Recycling Waste Polypropylene to Produce New Composite Materials with Jute Reinforcements
Authors: Hoque Mohammad Amirul , Sultana Shahin , Sarker Md. Khabir Uddin , Islam Zahidul 
Published: September 2023

Abstract
Waste polypropylene (PP) polymer was collected, washed, dried and mechanically recycled into granules. Natural fibers are a sustainable and renewable resource, and in this work, Corchorus olitorius jute fiber was used as a reinforcing agent with waste PP. Jute fiber was collected from local market, cleaned, dried and cut into 1-2 mm in length for the production of waste PP-jute composites. The molecular structure of waste PP and virgin PP were characterized by the attenuated total reflection-fourier transform infrared (ATR-FTIR). The purpose of the current research was to examine the effectiveness of waste PP by comparing waste PP-jute composites and virgin PP-jute composites. The injection molding process was utilized to make jute fiber reinforced waste PP composites with various jute fiber loadings (5%, 10%, 15%, 20%, 25%, and 30% in weight).The same process was used to produce virgin PP composites reinforced with jute fiber. All composites undergo water absorption and tensile testing in order to assess the recycled PP. Injection molded virgin and waste PP's physico-mechanical, thermal, and tensile strengths are also examined. In comparison to waste PP, virgin PP has a 6% greater tensile strength and a 19% higher elongation at break. Results from waste PP-jute composites and virgin PP-jute composites did not significantly differ from one another. Products made from recycled PP can thus be both economically and environmentally viable.
Numerical Analysis of Fracture Behavior of Functionally Graded Materials using 3D-XFEM
Authors: Benhamena Ali , Fatima Benaoum , Foudil Khelil , Baltach Abdelghani , Chaouch Mohamed Ikhlef 
Published: September 2023

Abstract
This paper presents the numerical evaluation of mixed stress intensity factors (SIFs) and non-singular terms of William's series (T-stress) of functionally graded materials (FGMs) using three-dimensional extended finite element method (3D-XFEM). Four-point bending specimen with crack perpendicular to material gradation have been used in this investigation in order to study the effect of some parameters (crack position, crack size, specimen thickness) on the failure of FGMs materials. The fracture parameters (KI KII, phase angle ψ and T-stress) obtained by the present simulation are compared with available experimental and numerical results. An excellent correlation was found of the 3D-XFEM simulations with those available in the literature. From the numerical results, a fitting procedure is performed in order to propose an analytical formulation and subsequently are validated against the 3D-XFEM results.
Austenite-Grain-Growth Kinetics and Mechanism in Type 347H Alloy Steel for Boiler Tubes
Authors: Huda Zainul , Zaharinie Tuan , Aniszulaikha Ireen , Almitani Khalid 
Published: September 2023

Abstract
The research material (type 347H alloy steel) has been characterized using optical microscopy and an EDS/SEM system. Annealing experiments have been conducted at temperatures range of 600–1050°C for 30 min–20 h by using an atmosphere-controlled furnace. Normal grain growth with intermediate grain size has been related to the favouring of creep resistance to recommend the material suitable for boiler tubes at operating temperatures up to 750°C for long duration. The kinetics of grain growth in the 347H has been shown to behave similar to a pure metal in the initial stage of annealing in the range of 0–30 min, beyond which the grain-growth process was found to be suppressed due to second-phase (NbC) particle-pinning and solute drag effects. The grain-growth exponent n is computed to be in the range of 0.117–0.313; the deviation from ideal kinetic behavior (n=0.5) has been scientifically justified. The activation energy for grain growth Qg, for the investigated alloy, has been graphically computed and validated.
GC-MS profile and antimicrobial activities of extracts from root of Senna occidentalis Linn.
Authors: Amako Ngozi Francesca , Mgbemena Mary-Ann Nkoli , Odo Sunday Peter 
Published: September 2023

Abstract
We considered the extraction of plant materials from Senna occidentalis root, and its fractionation monitored by bioassay towards isolating its bioactive principles. Pulverized root sample of Senna occidentalis (fam. leguminaceae) was extracted with methanol using a maceration method. The crude methanol extract (MSo) 6.06 g was partitioned into petroleum ether and ethyl acetate to yield their respective fractions viz: petroleum ether fraction (1.20 g), ethyl acetate fraction (1.86 g) and methanol fraction (2.92 g). The crude methanol extract was analyzed using phytochemical screening, infrared spectroscopy, and gas chromatography/mass spectrometry while the fractions were examined for antimicrobial properties. Phytochemical screening indicated the presence of tannins, phenolics, alkaloids, flavonoids, saponins, cardiac glycosides, phlobatannin, and absence of steroids. The infrared spectrum revealed a broad absorption band at 3437.26 cm-1 due to O-H symmetric stretch in polymeric alcohols, and absorption frequency of 1640.51cm-1 of moderate intensity due to C=O stretch. Enols are easily identified by the broad H-bonded O-H stretch absorption and low C=O stretch frequency as in β-keto enolic esters and phenol acetates, -CO-O-C=C-, (1690-1650 cm-1). Gas chromatography/mass spectrometry identified the presence of ten compounds including n-hexadecanoic acid (23.76%), linoleic acid (1.64%), E-9-tetradecenoic acid (4.88%), octadecanoic acid, 2-(2 hydroxyethoxy) ethyl ester (6.24%) and E-2-octadecadecen-1-ol (13.74%). Similar broad spectrum antimicrobial activities were manifested by methanol and ethyl acetate fractions. Escherichia coli and Bacillus cereus were the most susceptible with the highest zone of inhibition of 30 mm and 28 mm respectively at minimum inhibition concentration of 1.35 x103 μg/ml. The methanol fraction has the highest potency against the tested pathogens whereas the petroleum ether fraction exhibited activity only on gram negative pathogens. The antimicrobial activities observed in these fractions suggest the presence of active chemical components in the crude methanol root extract of Senna occidentalis thus provides a potential source of novel antimicrobial agents. Further work is however, required to isolate and characterize these bioactive principles.
Are All Text News Just a Noise for Investors? Impact of Online Texts on Bitcoin Returns
Authors: Damjanović Aleksandar , Drenovak Mikica 
Published: September 2023

Abstract
The paper demonstrates the power of alternative data. Relying on the indicators obtained by mining online publicly available news articles, authors analyze their impact on Bitcoin returns. This research shows that in the first quarter of 2022 Bitcoin returns could be explained by the sentiment of information obtained from news published on online portals. However, we find negative relation between Bitcoin news sentiment and its returns. Such result can be explained as anomaly of researched period which is characterized by inception of global political crisis caused by the war in Eastern Europe and turmoil on crypto market. Our research also confirms that the news about Ethereum, Bitcoins’ investment substitute, affected Bitcoin's returns as well. On the other hand, the obtained results show that there is no relation between the lexical readability of the news (i.e., the clarity with which the text is written, measured by the fog index) and the returns on Bitcoin in the analyzed period. Collected evidences speak in favor of Bitcoin’s market inefficiency. In this paper we also demonstrate that returns forecasts based on online news are more accurate in comparison to those generated by ARMA-GARCH model, a conventional financial tool for predicting returns.
The Relationship Between Internal Factors and Employees' Perception of an Organization's Green Performance
Authors: Milanović Vesna , Jurčić Ana , Matić Andrea Bučalina 
Published: September 2023

Abstract
This paper examines the relationship between internal factors of an organization and employees' perception of organization's green performance – EPGP. An organization's green performance is greatly influenced by its internal efforts toward the implementation of green practices (such as internal green marketing – IGM and its dimensions), and it can be greatly influenced by employees' attitudes and behavior as well (such as organizational identification – OI, employees' satisfaction – ES, employees' eco-friendly behavior – EFB). Therefore, it was considered justified to examine whether each IGM dimension is related to EPGP, and whether each observed employees' attitude and behavior is related to EPGP. Hypotheses were tested on a sample of 177 respondents – employees working in different, mostly service organizations in Serbia, using the regression and correlation analysis. The obtained results revealed that each observed variable is positively related to EPGP. However, in predicting EPGP the contribution of green internal communication – GIC (as the IGM dimension), OI and EFB is statistically significant. The findings provide insight into the relationship between each observed variable and EPGP, and it may be useful for managers in the environmental management process.
Optimizing industrial growth through alternative forest biomass resources: A mathematical model using DDE
Authors: Dipesh  , Kumar Pankaj , Cattani Carlo 
Published: September 2023

Abstract
This paper focuses on the classification of forest biomass into two categories: premature and mature forest biomass. The third variable considered is industrialization. The growth of the wood-based industry is believed to be closely tied to the population of mature forest biomass. Any scarcity of the mature population could have a negative impact on industrialization. So, pre-mature forest biomass is provided as an alternative for industrial growth. The industrialization growth is assumed to be based on a modified Leslie-Gower equation. The positivity and boundedness of the system are calculated using the comparison theorem. Stability analysis is done about nonzero equilibrium points with the help of the Routh-Hurwitz theorem. When there is no delay in the system, the system is stable. At τ< 1.8, the system shows asymptotic stability, but at τ ≥ 1.8, system shows Hopf-bifurcation and periods oscillations occur. Furthermore, sensitivity analysis is examined about different parameters of the systems. MATLAB is used to draw the numerical simulation.
Technics, Perception, Différance Narrating the Seeing-Machine?
Authors: Palatinus David Levente 
Published: September 2023

Abstract
This article offers a discussion of the intricate relation between the human body and its technological supplementation. It argues that while the physical body may seem to sublimate in the plethora of discourses, it keeps reasserting its materiality via processes of technologization which capture perception and cognition in a constant cycle of disembodiment and re-embodiment. The article offers an analysis of Elizabet Goldring’s work with the Seeing Laser Ophthalmoscope, and her RetinaPrints (a unique form of visualization) to comment on the ways in which lived experiences are inexorably linked to practices of fragmentation, prosthesis and technological mediation.
Green supply chain drivers and their implementation on LEED-certified projects in India
Authors: Koul Pawan , Ghatak Ranjit Roy , Sinha Kunal 
Published: September 2023

Abstract
This study aims to identify the most critical green supply chain drivers and to explore the most prevalent drivers in the real estate industry in India. Through literature review, we identified 13 green drivers in the real estate sector in India. A structured questionnaire was administered to 280 potential participants, out of whom 150 responded by filling out the questionnaire. The respondents were working in reputed real estate companies comprising owners, contractors, consultants, architects, and project management companies in Delhi National capital region (NCR). The relative relevance index was used to rank the various green drivers in the real estate industry in India. Multiple regression analysis was used to establish the degree of linear connection between the variables. T-tests examine the differences between 13 decision factors and dependent variables. The cost–benefit of green supply chain drivers in a LEED-certified real estate project in India established the efficacy of green supply chain drivers in the real estate industry in India. The study’s findings indicate that senior management, developers, and the government are the most crucial drivers for implementing the green supply chain in the real estate sector. The study’s findings further confirm that green building approaches, i.e., green procurement, green transportation, building information modelling (BIM), building energy modelling (BEM), and prefabrication procedures, are underutilised in the real estate sector in India.
Protecting the intellectual property of built environment designs using blockchain technology
Authors: Darabseh Mohammad , Martins João Poças 
Published: September 2023

Abstract
Digital design and modelling for construction assets was an important step towards improving the construction process overall by improving its efficiency and productivity, reducing the time needed for design editing and rework. However, digital forms of designs are prone to cyber threats and misuse by unauthorised authors. This is a common problem in different industries wherein digital asset management is inefficient due to its centralisation and depends on humans following a certain procedure. Blockchain is an emerging technology capable of transferring digitally produced information into a transferable digital value by storing the information or an identifying signature for the information on a blockchain ledger. Information on the blockchain ledger is immutable and stored in a decentralised system, making it a permanent record. This article investigates the possibility of protecting the intellectual property of built environment designs using blockchain technology. The article presents a solution for generating a double-fingerprint identity for the Industry Foundation Classes (IFC), a common format for built environment design exchange, followed by deployment of a smart contract on the Ethereum public blockchain to store the design fingerprint along with design meta-data, such as information about the the owner and version, as a non-fungible token, a unique asset format stored on a blockchain ledger.
Numerical Analysis of Inductive Proximity Sensors for Non-Ferrous Targets
Authors: Petrescu Maria-Cătălina , Petrescu L. 
Published: September 2023

Abstract
Proximity sensors are devices found in many fields of activity from the automotive area to robotics and beyond. Among them, proximity sensors occupy an important place due to their low price and reliable response. They are found in a wide range of sizes and detection distances. In this work, a comparative study was carried out on two constructive solutions - one shielded and one unshielded. The response provided by the sensor was followed through a 2D FEMM analysis varying a series of parameters: the material from which the target is made, the distance between the target and the sensor, as well as its operating frequency. The results highlight the influence of these parameters by changing some quantities of a magnetic nature such as the spectrum of the magnetic flux density, the magnetic energy stored by the target, respectively the inductance of the sensor coil.
RANCANG BANGUN LAMPU OTOMATIS DAN MONITORING SUHU RUANGAN BERBASIS INTERNET OF THINGS MENGGUNAKAN NODEMCU V3 DAN BLYNK
Authors: Muhammad ilham hakim  , Kakang Nurwahid  , Ganis Sanhaji  
Published: September 2023

Dari waktu ke waktu, komsumsi listrik terus meningkat dengan cepat. Rata-rata pertumbuhan komsumsi listrik pada saat ini adalah 2,3-2,5%, dan akhir tahun 2030, diperkirakan kebutuhan energy listrik akan menjadi dua kali saat ini yang berkisar sekitar 16.000 TWh pertahunnya Hal-hal kecil yang sering dilakukan selama ini, mungkin tanpa kita sadari telah mengakibatkan dampak besar dan bila terus menerus dilakukan akan mengakibatkan kelangkaan energi listrik. Hal ini dapat terjadi karena gaya hidup komsumtif yang boros dan tidak efisien, Perilaku komsumtif terhadap energy listirk ini dapat mengubah pola dan gaya hidup menjadi lebih boros. Masalah pemborosan energy listrik ini sebesar 80% disebabkan manusia dan 20% disebabkan oleh factor teknis, hal ini dikarenakan banyaknya pemakaian listrik yang berlebihan dan tidak sesuai waktunya Salah satu solusi dari permasalahan tersebut dapat diatasi dengan menggunakan teknologi Internet of Things. Pada proyek ini dibuat rancang bangun lampu otomatis menggunakan sensor PIR, sensor LDR, dan monitoring suhu DHT11 dengan nodeMCU dan Blynk, untuk meningkatkan efisiensi penggunaan listrik di rumah. Lampu otomatis merupakan sistem yang dapat mengontrol lampu secara otomatis sesuai dengan kebutuhan. Sensor PIR dan LDR akan mendeteksi keberadaan gerakan dan kegelapan di ruangan, sehingga lampu hanya akan menyala jika diperlukan saja. Selain itu, sistem ini juga memiliki fitur monitoring suhu yang dapat memantau suhu ruangan secara realtime yang bisa di akses diaplikasi Blynk. Dengan sistem ini, pengguna dapat lebih hemat listrik dan terhindar dari kebakaran akibat lampu yang terus menyala.
Kata Kunci: komsumsi listrik,node mcu v3, PIR, LDR, DHT11