bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing peer-to-peer reference services in a community college library
Authors: Scripa Allison , Spencer Mary Ellen 
Published: February 2023

PurposeThe authors discuss the challenges and successes in implementing a peer reference service model in a community college library.Design/methodology/approachThe authors present a case study about the development of a peer reference service at a community college library. The article includes a chronological overview of the program, a brief literature review, the authors’ own observations, interviews with student employees, comments from librarians working with the students and reference service data. They reviewed local reference service data, conducted a limited review of the literature, interviewed librarians at a university with a peer reference assistance program and incorporated their own observations to create the Pellissippi Ambassadors for Library Success program.FindingsFindings suggest that peer reference services benefit student employees, student researchers and librarians.Research limitations/implicationsThe article does not include a comprehensive literature review.Originality/valueThe study discusses peer reference services in a community college library setting and can be of use to librarians implementing peer reference services.
Experiences of overseas doctoral researchers in Australian business schools: implications for stakeholders
Authors: Ong Wee Ming , Dhakal Subas Prasad 
Published: February 2023

Purpose
Although the international education sector is one of the significant contributors to the Australian economy, international students continue to experience various forms of social inequalities. This paper aims to focus on overseas doctoral researchers (ODRs) – candidates and graduates – and capture their experiences.

Design/methodology/approach
Drawing on the adaptive capacity framework, an exploratory qualitative study was carried out based on interviews with doctoral candidates (n = 6), doctoral graduates (n = 5) and supervisors (n = 4) in various Business Schools in Australian universities. Given this study’s exploratory and interpretive nature, the research question was deliberately broad: what insights can be generated for key stakeholders by capturing the experiences of ODRs in Australia through the lens of adaptive capacity?

Findings
Findings indicate that financial pressure, social exclusion and cultural bias were the three main challenges ODRs had to overcome; female ODRs perceived that supervisors and faculties often overlooked the mental health aspects; and better pedagogy of research supervision, institutional support and national policies are needed to develop adaptive ODRs.

Research limitations/implications
If ODRs are to become an integral part of the knowledge economy, key stakeholders need to focus on support mechanisms for these researchers. That way, Australian universities can not only improve their image of treating international students only as a part of the revenue flow but also enhance the educational experiences of ODRs and set them up for future success.

Originality/value
The contribution of this paper is twofold. First, it demonstrates the utility of the adaptive capacity lens to capture the experiences of ODRs. Second, it discusses research implications for the three key stakeholders: supervisors, higher education institutions and the government.
Investigating gender variations of using attitude choices in letters of recommendations
Authors: Alotaibi Hmoud 
Published: February 2023

PurposeThe main objective of the present study is to explore whether there are variations in the employment of evaluative language resources by male and female writers. More specifically, the study focuses on variations, if any, that can be attributed to difference in gender.Design/methodology/approachThe study compared and contrasted forty recommendation letters written by male academics to the same number of letters written by female recommenders. The study uses both quantitative and qualitative approaches.FindingsThe investigation of three attitudinal resources in letters of recommendations showed that the most employed resource was the judgment sub-system. The appreciation domain was in the second position, and the least frequent was the affect. The results also revealed no statistically significant variations in attitude sub-systems: Affect and appreciation as the writers in both groups (males and females) employed almost the same options in each. In respect with judgment, however, the analysis explored significant differences between the two sets as male academics used more judgment resources than females.Originality/valueThe main contributions of this study may be as follows: first, it is one of very few studies drawing on the attitude-category of appraisal system, as an analytical tool to examine gender differences in recommendation letters very particularly on the ones written by non-native speakers of English. Second, the gender factor is central in the genre of the recommendation letters and hence researchers should be cognizant of its role as certain variations might be impacted by it. Third, the lists of tokens can be offered as heuristics for academics to have most common words or phrases to use in their letters. Finally, the findings can hopefully bear some important pedagogical implications, very specifically for novice and non-native academic writers of recommendations letters.
Differences in the regulatory strategies of marine oligotrophs and copiotrophs reflect differences in motility
Authors: Noell Stephen E. , Brennan Elizabeth , Washburn Quinn , Davis Edward W. , Hellweger Ferdi L. , Giovannoni Stephen J. 
Published: February 2023

AbstractAquatic bacteria frequently are divided into lifestyle categories oligotroph or copiotroph. Oligotrophs have proportionately fewer transcriptional regulatory genes than copiotrophs and are generally non‐motile/chemotactic. We hypothesized that the absence of chemotaxis/motility in oligotrophs prevents them from occupying nutrient patches long enough to benefit from transcriptional regulation. We first confirmed that marine oligotrophs are generally reduced in genes for transcriptional regulation and motility/chemotaxis. Next, using a non‐motile oligotroph (Ca. Pelagibacter st. HTCC7211), a motile copiotroph (Alteromonas macleodii st. HOT1A3), and [14C]l‐alanine, we confirmed that l‐alanine catabolism is not transcriptionally regulated in HTCC7211 but is in HOT1A3. We then found that HOT1A3 took 2.5–4 min to initiate l‐alanine oxidation at patch l‐alanine concentrations, compared to <30 s for HTCC7211. By modelling cell trajectories, we predicted that, in most scenarios, non‐motile cells spend <2 min in patches, compared to >4 min for chemotactic/motile cells. Thus, the time necessary for transcriptional regulation to initiate prevents transcriptional regulation from being beneficial for non‐motile oligotrophs. This is supported by a mechanistic model we developed, which predicted that HTCC7211 cells with transcriptional regulation of l‐alanine metabolism would produce 12% of their standing ATP stock upon encountering an l‐alanine patch, compared to 880% in HTCC7211 cells without transcriptional regulation.
Economic Growth Theory and Natural Resource Constraints: A Stocktake and Critical Assessment
Authors: Maris Robbie , Holmes Mark 
Published: February 2023

AbstractSociety is facing significant environmental challenges. The effects of climate change, biodiversity loss and environmental degradation are being increasingly felt worldwide. In recent years, researchers have attempted to adapt neoclassical and endogenous growth theory to account for constraints imposed by scarce natural resources. In this article, we review where, and how, researchers tend to incorporate natural resources and natural capital into growth theory. We then outline areas and questions that remain unanswered, including how novel impact investing and the eroding trade‐off between GDP and the environment affect growth theory.
‘That was all over the shop’: Exploring the COVID‐19 response in disability residential settings
Authors: McAllister Ashley , Dickinson Helen , Huska Marie , Devine Alexandra , Dimov Stefanie , Kavanagh Anne 
Published: February 2023

AbstractPeople with disability are an ‘at‐risk’ group in a pandemic context for various clinical and structural reasons. However, in the early stages of the COVID‐19 pandemic, people with disability were not identified as a priority group, which exacerbated this risk, particularly for those living in congregate settings. This paper examines inter‐organisational issues during the second wave of the COVID‐19 pandemic in disability residential settings gathered from senior managers, team leaders, and disability support workers. We use Victoria as a case study since several Victorian disability residential settings were in mid‐transition from state provision to non‐profit organisations. We argue that residential settings in mid‐transition had clearer lines of organisational accountability and communication, which was thought to reduce the impact of outbreaks compared to residential settings in other States and Territories with multiple lines of communication and blurred accountability. The paper contributes to the literature on inter‐organisational collaboration by reinforcing the necessity of clear lines of accountability and leadership in collaborative governance during emergencies. The evidence suggests how government and disability residential settings could better support residents and staff in future COVID‐19 outbreaks or other pandemics.Points for practitioners
People with disability, particularly those living in congregate settings, are often at heightened risk during public health emergencies.
Clearer lines of responsibility, administrative, and communication arrangements across organisations and governments, alongside tailored responses within residential settings, are required to keep ‘at‐risk’ individuals safe.
Emergency management block funding could be designed to alleviate the financial pressures identified in this study for residential disability services in future pandemic responses.
John Pechey (1654–1718) and the Popularization of Learned Medicine
Authors: Rovelli Giulia 
Published: February 2023

AbstractThis essay offers a corpus‐based linguistic analysis of the paratexts of the works of John Pechey (1654–1718), a licentiate physician and prolific medical author and popularizer, whose ideas and practice brought him into conflict with the Royal College of Physicians. Following the methodology of corpus‐assisted discourse analysis, historical discourse analysis, and historical sociopragmatics, the essay analyses the paratextual material of Pechey's medical publications, with the aims of (a) collecting a corpus of texts published under his name, (b) assessing his role in the popularization of learned medicine, and (c) tracing how he constructed and performed his identity both as a knowledgeable medical practitioner and as a critic of the beliefs and practices of the Royal College of Physicians.
Refining stereotactic body radiation therapy as a bridge to transplantation for hepatocellular carcinoma: An institutional experience
Authors: Chen Beini , Butler Nick , O'Rourke Thomas , Hodgkinson Peter , Stuart Katherine , Shih Edwin , Leggett David , Pryor David , Liu Howard , Lee Dominique 
Published: February 2023

AbstractBackgroundStereotactic body radiotherapy (SBRT) has been established as a safe and effective treatment for hepatocellular carcinoma (HCC). Currently, there are no consensus guidelines to advise optimal patient selection and radiotherapy planning parameters to minimise the risk of surgical and medical complications after liver transplant (LT) in patients who have had prior SBRT for HCC, whilst optimising treatment benefit.MethodsWe performed a retrospective analysis of all adult patients who received liver SBRT as a bridge to LT at a tertiary institution between 2017 and 2019.ResultsNine patients received SBRT as bridging therapy to LT. HCC location varied from peripheral to central/hilar regions and HCC diameter was 13–54 mm. Median time between SBRT and LT was 141 days (range 27–461 days). Median operating time was 360 min (range 270–480 min). Four patients (44%) had visible SBRT reaction or fibrosis at the time of LT. SBRT reaction resulted in clinical impact in one patient (11%) only, where vascular clamping of the IVC was required for 10 min.ConclusionSBRT is a safe and effective treatment for HCC enabling patients to remain within LT criteria, even for lesions not amenable to other more conventional bridging therapies. We describe a preliminary decision pathway to guide the optimal use of SBRT as a bridge to LT developed in our institution.
Multicentric reticulohistiocytosis with eosinophilic gastroenteritis: An unusual relationship
Authors: Fan Junyu , Jiang Ting , Qin Yingying , Ding Qin , Cheng Xia , He Dongyi 
Published: February 2023

AbstractMulticentric reticulohistiocytosis (MRH) is a rare disease with poorly defined therapeutic strategies. Here, we report the case of a patient with eosinophilic gastroenteritis who developed MRH after 5 years. The patient presented with disabling and rapidly progressive polyarthralgia, eosinophilic gastroenteritis, and resistance to first‐line therapies. However, there was a marked improvement in the arthritis symptoms following treatment with tofacitinib. This presentation provides a useful perspective for the therapeutic management of complex scenarios involving MRH.
Carboxypeptidase vitellogenic like facilitates resistance to CDK4/6 inhibitors in breast cancer
Authors: Zhu Xiang , Xu Xiaojie , Zhang Lin , Yang Xuhui 
Published: February 2023

AbstractObjectiveInhibitors of cyclin‐dependent kinase 4 and 6 (CDK4/6) are targeted therapeutic drugs for breast cancer treatment. The mechanism of resistance to these inhibitors requires further investigation.MethodsWe used bioinformatics to screen differentially expressed genes between cells that were susceptible and resistant to CDK4/6 inhibitors. Quantitative real‐time PCR (qRT‐PCR) was used to identify gene expressions in different cell lines. Cell viability, colony formation, cell cycle, and apoptosis assays were used to evaluate the effect of carboxypeptidase vitellogenic like (CPVL) on breast cancer cells under the condition of CDK4/6 inhibitors. Gene set enrichment analysis (GSEA) suggested the potential regulatory pathway of CPVL in breast cancer. Xenograft formation assay was conducted in nude mice to study the role of CPVL in vivo.ResultsBased on bioinformatics analysis and qRT‐PCR, CPVL was identified more abundantly in cells that were resistant than sensitive to CDK4/6 inhibitors. Overexpressed or knocked down CPVL regulated the effects of CDK4/6 inhibitors in resistant cell lines. GSEA showed that resistance might be induced by CPVL through altered phosphatase and tensin homolog (PTEN)‐related pathways. Our findings showed that CPVL negatively regulates PTEN to impact the anticancer effects of CDK4/6 inhibitors in vitro and in vivo.ConclusionCPVL might be a key factor in regulating breast cancer resistance to CDK4/6 inhibitors.
Aggrelyte‐2 promotes protein solubility and decreases lens stiffness through lysine acetylation and disulfide reduction: Implications for treating presbyopia
Authors: Panja Sudipta , Nahomi Rooban B. , Rankenberg Johanna , Michel Cole R. , Gaikwad Hanmant , Nam Mi‐Hyun , Nagaraj Ram H. 
Published: February 2023

AbstractAging proteins in the lens become increasingly aggregated and insoluble, contributing to presbyopia. In this study, we investigated the ability of aggrelyte‐2 (N,S‐diacetyl‐L‐cysteine methyl ester) to reverse the water insolubility of aged human lens proteins and to decrease stiffness in cultured human and mouse lenses. Water‐insoluble proteins (WI) of aged human lenses (65–75 years) were incubated with aggrelyte‐2 (500 μM) for 24 or 48 h. A control compound that lacked the S‐acetyl group (aggrelyte‐2C) was also tested. We observed 19%–30% solubility of WI upon treatment with aggrelyte‐2. Aggrelyte‐2C also increased protein solubility, but its effect was approximately 1.4‐fold lower than that of aggrelyte‐2. The protein thiol contents were 1.9‐ to 4.9‐fold higher in the aggrelyte‐2‐ and aggrelyte‐2C‐treated samples than in the untreated samples. The LC–MS/MS results showed Nε‐acetyllysine (AcK) levels of 1.5 to 2.1 nmol/mg protein and 0.6 to 0.9 nmol/mg protein in the aggrelyte‐2‐ and aggrelyte‐2C‐treated samples. Mouse (C57BL/6J) lenses (incubated for 24 h) and human lenses (incubated for 72 h) with 1.0 mM aggrelyte‐2 showed significant decreases in stiffness with simultaneous increases in soluble proteins (human lenses) and protein‐AcK levels, and such changes were not observed in aggrelyte‐2C‐treated lenses. Mass spectrometry of the solubilized protein revealed AcK in all crystallins, but more was observed in α‐crystallins. These results suggest that aggrelyte‐2 increases protein solubility and decreases lens stiffness through acetylation and disulfide reduction. Aggrelyte‐2 might be useful in treating presbyopia in humans.
Immunolocalization of vesicular glutamate transporter 2 and exocytosis‐related proteins in afferent nerve endings innervating taste buds in the rat incisive papilla
Authors: Yokoyama Takuya , Ito Motoi , Yamamoto Yoshio , Hirakawa Masato , Sakanoue Wakana , Sato Kenichi , Saino Tomoyuki 
Published: February 2023

AbstractThe present study aimed to investigate the immunolocalization of vesicular glutamate transporter (VGLUT) 1 and 2, and proteins associated with exocytosis, i.e., core components of the soluble N‐ethylmaleimide‐sensitive factor attachment protein receptor complex (synaptosomal‐associated protein of 25 kDa, syntaxin 1, and vesicle‐associated membrane protein 2) and synaptotagmin‐1 (Syt1), in incisive papillary taste buds of rats using double‐indirect immunofluorescence. No VGLUT1 immunoreactivity was observed, whereas VGLUT2‐immunoreactive punctate products were closely associated with guanine nucleotide‐binding protein G(t) subunit α3‐immmunoreactive cells in taste buds. VGLUT2 was immunolocalized in P2X3 purinoceptor‐expressing afferent nerve endings. Synaptosomal‐associated protein of 25 kDa, syntaxin 1, and vesicle‐associated membrane protein 2 were immunolocalized in nerve endings containing VGLUT2‐immunoreactive products as well as a few cells in taste buds. VGLUT2 was co‐immunolocalized in some intragemmal nerve endings immunoreactive for Syt1, a calcium sensor implicated in vesicle membrane fusion. The present results suggest that afferent nerve endings innervating incisive taste buds release glutamate by exocytosis to modulate taste cell function.
Access to community water fluoridation in rural Victoria: It depends where you live…
Authors: Dickson‐Swift Virginia , Crocombe Leonard , Bettiol Silvana , Bracksley‐O'Grady Stacey 
Published: February 2023

AbstractObjectiveTo explore the water fluoridation status of rural Victorian towns over 1000 population and document the oral health profile in the local government areas (LGAs) currently with no water fluoridation. To assist/inform future LGA planning, we describe a case study of a community‐based co‐design approach to increase access to fluoridated water in rural communities.DesignA descriptive design and a case study.SettingRural Victorian towns over 1000 population.ParticipantsTwenty‐nine LGAs in rural areas.Main Outcome Measure(s)LGA water fluoridation status and oral health profiles.ResultsSixty‐six (33%) of the 203 Victorian rural towns with >1000 population, representing 149 251 people, did not have access to fluoridated water. Towns in 29 rural LGAs were included with 62% without water fluoridation with many having higher than the Victorian average of preventable hospital admissions due to dental conditions in children aged 0–9 years. Over 50% of children aged 0–12 years living in these rural nonfluoridated LGAs had above‐the‐state average rates of decayed, missing and filled teeth (dmft/DMFT). In those aged 0–5 years, this was the highest with 78% above‐the‐state average. In the case study, meetings were well attended, and the group resolved to lobby for water fluoridation, which was successful.ConclusionMany Victorian rural towns do not have access to fluoridated water. A community‐based co‐design approach can dispel ill‐informed concerns about dangers of water fluoridation to successfully lobby the state government to fluoridate the local water supply.
Cultural values, system justification, meritocratic beliefs, and evaluations of governments' performance in handling the COVID‐19 crisis
Authors: Zhai Yida , Wu Qidi , Lu Yizhen 
Published: February 2023

AbstractSystem justification and meritocratic beliefs legitimize the status quo of economic, social, and political arrangements, and may correlate with favourable evaluations of governments' performance during the COVID‐19 pandemic. This study furthers research on this topic by examining (1) the cultural value antecedents of system justification and meritocratic beliefs, and (2) the differential effects of these on attitudes toward ingroups and outgroups from an intergroup perspective. The results show that collectivist values positively predict system justification and meritocratic beliefs, whereas a similar effect was not observed for individualist values. As hypothesized, system justification motivation was positively associated with favourable evaluation of the Chinese government (an ingroup). By contrast, system justification and meritocratic beliefs were negatively associated with evaluation of the American government (an outgroup). We discussed the implications for understandings of the cultural value bases of system justification and meritocratic beliefs, and the relevance of the lens of intergroup relations in studying those beliefs.
Effects of topical corticosteroid versus tacrolimus on insulin sensitivity and bone homeostasis in adults with atopic dermatitis—A randomized controlled study
Authors: Gether Lise , Storgaard Heidi , Kezic Sanja , Jakasa Ivone , Hartmann Bolette , Skov‐Jeppesen Kirsa , Holst Jens J. , Pedersen Anders J. , Forman Julie , van Hall Gerrit , Sørensen Ole E. , Skov Lone , Røpke Mads A. , Knop Filip K. , Thyssen Jacob Pontoppidan 
Published: February 2023

AbstractIntroductionTopical corticosteroids (TCS), used to treat atopic dermatitis (AD), have been associated with type 2 diabetes and osteoporosis in epidemiological studies, possibly explained by systemic absorption.ObjectivesWe examined whether intensive daily whole‐body TCS treatment over 2 weeks followed by twice weekly application for 4 weeks could elicit insulin resistance and increase bone resorption in adults with AD.MethodsA randomized parallel‐group double‐blind double‐dummy non‐corticosteroid‐based active comparator study design was completed in Copenhagen, Denmark. Thirty‐six non‐obese, non‐diabetic adults with moderate‐to‐severe AD were randomized to whole‐body treatment with betamethasone 17‐valerate 0.1% plus a vehicle once daily or tacrolimus 0.1% twice daily after washout. Insulin sensitivity assessed by the hyperinsulinemic‐euglycemic clamp combined with tracer infusions and biomarkers of bone formation (P1NP) and resorption (CTX) were evaluated at baseline, after 2 weeks of daily treatment and after further 4 weeks of twice‐weekly maintenance treatment.ResultsAD severity improved with both treatments and systemic inflammation was reduced. After 2 weeks, we observed similar increase in peripheral insulin sensitivity with use of betamethasone (n = 18) and tacrolimus (n = 18). Bone resorption biomarker, CTX, was unchanged, while bone formation marker, P1NP, decreased after betamethasone treatment after both 2 and 6 weeks but remained unchanged in the tacrolimus arm.ConclusionsWhole‐body treatment with TCS leads to systemic exposure but appears not to compromise glucose metabolism during short‐term use, which may be a result of reduced systemic inflammatory activity. The negative impact on bone formation could be regarded an adverse effect of TCS.