bluuebunny/crossref_metadata_2025_split huggingface dataset:
Symptomatic intracranial tumors in pregnancy: an updated management algorithm. Illustrative case
Authors: Zohdy Youssef M. , Agam Matthew , Maldonado Justin , Jahangiri Arman , Pradilla Gustavo , Garzon-Muvdi Tomas 
Published: May 2023

BACKGROUND
Intracranial tumors are infrequently encountered during pregnancy, and their diagnosis and management require a multidisciplinary approach to ensure the best possible outcomes for the mother and fetus. The pathophysiology and manifestations of these tumors are influenced by hormonal changes, hemodynamic modifications, and alterations in immunological tolerance that occur during pregnancy. Despite the complexity of this condition, no standardized guidelines exist. This study aims to highlight the key points of this presentation, along with the discussion of a possible management algorithm.

OBSERVATIONS
The authors report the case of a 35-year-old woman who presented during the third trimester of pregnancy with severe signs of increased intracranial pressure (ICP) due to a posterior cranial fossa mass. The decision was made to stabilize the patient by placing an external ventricular drain to temporize her increased ICPs until the baby could be safely delivered via cesarean section. The mass was resected via suboccipital craniectomy 1 week postpartum.

LESSONS
In considering treatment modalities and their timing in patients presenting with intracranial tumors during pregnancy, each patient should be managed on the basis of an individual treatment algorithm. Symptoms, prognosis, and gestational age should be taken into account to optimize the surgical and perioperative outcomes of both the mother and fetus.
L-ORNITHINE-L-ASPARTAT IN PROPHYLAXIS OF CHEMOTHERAPY-INDUCED MUCOSITIS IN PATIENTS WITH MULTIPLE MYELOMA
Authors: Skrypnyk R.І. , Maslova G.S. 
Published: May 2023

Multiple myeloma is the second most common oncohematological malignancy in the world. The injury of gastrointestinal mucosal layer during the chemotherapy is caused by cytostatic effect of oncohematological medications. From the pathophysiological standpoint of multiple myeloma, the prophylaxis of chemotherapy-induced complications should include the agents that potentiate antioxidant defence.
The objective of this study is to evaluate the effectiveness of L-Ornithine-L-Aspartate in preventing chemotherapy-induced mucositis in patients with multiple myeloma.
Materials and Methods: Twenty-four patients diagnosed with multiple myeloma were included in the study. Two examinations were performed: one before starting chemotherapy and another after three courses of chemotherapy. Several biochemical markers were measured, including thiobarbituric acid reactive substances, catalase activity, and serum N-acetylneuraminic acid levels. The patients were divided into three groups: Group I (n=12) received chemotherapy alone, Group II (n=12) received L-Ornithine-L-Aspartate in addition to chemotherapy (10 g/day intravenously for 10 days, followed by 5 g twice a day for 20 days), and Group III (n=20) served as the control group comprising healthy individuals.
Results and Discussion: Initial examinations revealed higher levels of thiobarbituric acid reactive substances in both Group I (1.19 times, p=0.0342) and Group II (1.3 times, p=0.021) compared to the control group. In Group I, the administration of chemotherapy resulted in a 1.58-fold increase in thiobarbituric acid reactive substances (p=0.0025) compared to the initial examination. However, in Group II, which received L-Ornithine-L-Aspartate as an adjuvant therapy, the second examination showed a 1.33-fold decrease in thiobarbituric acid reactive substances (p=0.0005) compared to Group I.
Conclusion. Inclusion of L-ornithine-L-aspartate to adjuvant therapy during the conduction of chemotherapy provides decrease in severity of chemotherapy-induced oxidative stress and alleviates the severity of chemotherapy-induced mucositis.
Medial Temporal Lobe Atrophy in Predementia Alzheimer’s Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort
Authors: Jarholm Jonas Alexander , Bjørnerud Atle , Dalaker Turi Olene , Akhavi Mehdi Sadat , Kirsebom Bjørn Eivind , Pålhaugen Lene , Nordengen Kaja , Grøntvedt Gøril Rolfseng , Nakling Arne , Kalheim Lisa F. , Almdahl Ina S. , Tecelão Sandra , Fladby Tormod , Selnes Per 
Published: May 2023

Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. Methods: We used Automatic Segmentation of Hippocampal Subfields (ASHS) to determine MTL morphometry from MRI. We harmonized scanner effects using the recently developed longitudinal ComBat. Subjects were classified according to the A/T/N system, and as normal controls (NC), subjective cognitive decline (SCD), or mild cognitive impairment (MCI). Positive or negative values of A, T, and N were determined by cerebrospinal fluid measurements of the Aβ42/40 ratio, phosphorylated and total tau. From 406 included subjects, longitudinal data was available for 206 subjects by stage, and 212 subjects by A/T/N. Results: Compared to A–/T–/N– at baseline, the entorhinal cortex, anterior and posterior hippocampus were smaller in A+/T+orN+. Compared to NC A– at baseline, these subregions were also smaller in MCI A+. Longitudinally, SCD A+ and MCI A+, and A+/T–/N– and A+/T+orN+, had significantly greater atrophy compared to controls in both anterior and posterior hippocampus. In the entorhinal and parahippocampal cortices, longitudinal atrophy was observed only in MCI A+ compared to NC A–, and in A+/T–/N– and A+/T+orN+ compared to A–/T–/N–. Conclusion: We found MTL neurodegeneration largely consistent with existing models, suggesting that harmonized MRI volumetry may be used under conditions that are common in clinical multi-center cohorts.
Serum tumor markers for response prediction and monitoring of advanced lung cancer: A review focusing on immunotherapy and targeted therapies
Authors: van den Heuvel Michel , Holdenrieder Stefan , Schuurbiers Milou , Cigoianu Daniel , Trulson Inga , van Rossum Huub , Lang David 
Published: May 2023

BACKGROUND: The value of serum tumor markers (STMs) in the current therapeutic landscape of lung cancer is unclear. OBJECTIVE: This scoping review gathered evidence of the predictive, prognostic, and monitoring value of STMs for patients with advanced lung cancer receiving immunotherapy (IT) or targeted therapy (TT). METHODS: Literature searches were conducted (cut-off: May 2022) using PubMed and Cochrane CENTRAL databases. Medical professionals advised on the search strategies. RESULTS: Study heterogeneity limited the evidence and inferences from the 36 publications reviewed. While increased baseline levels of serum cytokeratin 19 fragment antigen (CYFRA21-1) and carcinoembryonic antigen (CEA) may predict IT response, results for TT were less clear. For monitoring IT-treated patients, STM panels (including CYFRA21-1, CEA, and neuron-specific enolase) may surpass the power of single analyses to predict non-response. CYFRA21-1 measurement could aid in monitoring TT-treated patients, but the value of CEA in this context requires further investigation. Overall, baseline and dynamic changes in individual or combined STM levels have potential utility to predict treatment outcome and for monitoring of patients with advanced lung cancer. CONCLUSIONS: In advanced lung cancer, STMs provide additional relevant clinical information by predicting treatment outcome, but further standardization and validation is warranted.
EFFECTIVENESS OF THERAPEUTIC TACTICS FOR ANALGESIA OF PATIENTS WITH GUNSHOT AND MINE-EXPLOSIVE WOUNDS AT THE STAGES OF TREATMENT
Authors: Kuchyn Iu.L. , Horoshko V.R. 
Published: May 2023

Background. The effectiveness of the use of therapeutic tactics for pain relief at the stages of treatment is important considering the fact that chronic pain is diagnosed in 83.3% of patients with mine-explosive wounds, and in 70% of cases with gunshot wounds. In civilian life, among injured patients, this diagnosis occurs in 11-40% of cases. There is not enough data on the reasons for such a high frequency of chronicity. Thus, the study of the effectiveness of treatment tactics for pain relief in patients with gunshot and mine-explosive wounds at the stages of treatment will play an important role and contribute to improving the results of treatment of this category of patients.
Aim: To investigate the effectiveness of therapeutic tactics of analgesia in patients with gunshot and mine-explosive wounds at the stages of treatment.
Materials and methods. The treatment of 1166 patients with injuries was analyzed. Pain intensity was diagnosed using a visual analog scale. Group comparisons were performed using the Mann-Whitney test and the chi-square test with allowance for continuity correction, Kruskal-Wallis, and post hoc comparisons were performed using Dunn's test.
Results. In patients with gunshot wounds, during the analysis, it was found that VAS data significantly depend on the type of anesthesia. Using regional anesthesia, VAS data are the lowest at all measurement points (p<0.05). In patients who received landmine-explosive injuries, VAS data are weakly dependent on the choice of anesthetic support, however, this indicator still has higher values (p<0.05) when using general anesthesia. Two-factor analysis showed a relationship between the dynamics of VAS data and the type of injury (p<0.001), type of anesthesia (p<0.001).
Conclusion. Admission of a patient with a wound to a medical center with subsequent analgesia using regional anesthesia methods has the best outcome in terms of pain management and pain control in such patients.
CARDIOVASCULAR DISEASES AND OBSTRUCTIVE SLEEP APNEA SYNDROME. REVIEW
Authors: Mostbauer H.V. , Bezrodnyi A.B. , Rokyta O.I. , Moskalenko Y.M. , Shevchyk M.I. 
Published: May 2023

Background. Cardiovascular disease (CVD) is one of the main causes of morbidity and mortality among adults worldwide. On another hand, obstructive sleep apnea syndrome (OSAS) is common in patients with CVD, and can worsen the patients prognosis due to late diagnosis.
Aim: to analyze and summarize the published researches about interrelation between CVD and OSAS, its influence on CVD, and the effects of continuous airway pressure (CPAP) treatment of OSAS on CVD in order to pay attention to OSAS potential risks, improve the investigation of this syndrome and management.
Materials and methods. Review of scientific literature in the international electronic scientometric databases PubMed, Google Scholar by key words for the period 2008-2023. The search was carried out by two independent authors. 150 sources were selected, 48 English–language articles of which met all the search criteria and were used for analysis.
Results. OSAS is one of the widespread sleep disorders that frequently occurs in patients with CVD, impairs quality of life. Its increases cardiovascular and all-cause mortality and cardiovascular morbidity. OSAS is observed in patients with arterial hypertension in 30-83%, coronary heart disease in 38-65%, stroke in 57-65%, heart failure in 12-55%, heart rhythm disorders - in 20-50%. In addition, the relationship between OSAS and diabetes, metabolic syndrome, insulin resistance, depression, and cognitive impairment has been established. OSAS is often not diagnosed or not diagnosed in time. Thus, there are data that 86-95% OSAS, clinically manifestated, were missed diagnosis, that worsens the prognosis of such patients.
Conclusions. OSAS is a common sleep breathing disorder in patients with CVD that is often diagnosed late. Most studies have shown that OSAS worsens the CVD course and outcomes. Therefore early diagnosis and timely appropriate treatment reduce morbidity and mortality.
Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients
Authors: Ameera A Radhi  , Iman S Jaafar  , Noor S Jaafar  , Sarah M Faisal  
Published: May 2023

Cocrystallization is an emerging approach for improving physico-chemical characteristics of an active pharmaceutical ingredient (API) for instance dissolution rate, solubility, stability in addition to mechanical
properties without affecting their therapeutic activity. It is of great importance when other approaches like salt or polymorph formation do not encounter the estimated targets.
In this review article, an outline of pharmaceutical cocrystals will be presented, with highlighting on factors affecting cocrystallization which include ∆pKa, donors and acceptors hydrogen bonds, molecular recognition point, synthon forming functional groups flexibility, dicarboxylic acid coformers carbon chain length and solvent effect, as well as and the methods for cocrystal preparation. Additionally, cocrystal characterization, dissolution pattern as well as the commercially available products were discussed.
Isolation and Characterization of Potential Lignin Peroxidase-Producing Bacteria from Compost Samples at Richards Bay (South Africa)
Authors: Dube Sindiswa L. , Osunsanmi Foluso O. , Ngcobo Bongekile P. , Mkhwanazi Londiwe B. , Jobe Zanele Z. , Aruleba Raphael T. , Mosa Rebamang A. , Opoku Andrew R. 
Published: May 2023

Abstract
Lignin recalcitrance is a key issue in producing value-added products from lignocellulose biomass. In situ biodegradable lignin-modifying enzymes-producing bacteria are considered a suitable solution to lignin biodegradation problems, but exploitation of ligninolytic bacteria is still limited to date. Hence, this study aimed to isolate and characterize potential lignin peroxidase ligninolytic bacteria from decomposing soil, sawdust, and cow dung at Richard Bay, South Africa. The samples were collected and cultured in the lignin-enriched medium. Pure isolated colonies were characterized through 16S rRNA gene sequencing. The ability of the isolates to grow and utilize aromatic monomers (veratryl and guaiacol alcohol) and decolorize lignin-like dyes (Azure B, Congo Red, Remazol Brilliant Blue R) was evaluated. Of the twenty-six (26) bacteria isolates 10 isolates, including Pseudomonas spp. (88%), Enterobacter spp. (8%), and Escherichia coli (4%) were identified as true lignin peroxidase producers. Pseudomonas aeruginosa (CP031449.2) and E. coli (LR025096.1) exhibited the highest ligninolytic activities. These isolates could potentially be exploited in the industry and wastewater treatment as effective lignin degrading agents.
Work motivation as a strategic development tool for the Greek forest service departments: Evidence from the region of Macedonia and Thrace
Authors: Konstantinidis Christos , Ntonti Maria , Zografou Stella , Kourtesi Sofia 
Published: May 2023

Attaining objectives might be difficult for the Greek Public Administration, which makes it essential to use for effective motivational tactics to raise staff performance and for realization of the organization's mission. It is considered that the public sector's human resources are its most valuable asset, it is deemed essential to motivate employees based on their unique qualities. Hence, the purpose of this work is to justify the factors that contribute to the commitment and improvement of the employees’ performance occupied in the Greek Forest Services of Macedonia-Thrace Region. All employees of the aforementioned services were asked to complete a questionnaire with the intention of learning more about what drives them, which is crucial information for academics and policymakers alike. From the results of the research emerged, that the most important motivational factor is the employees’ need to work for the common good and be part of an important vision. The ability to take initiative and participate in decision-making, the recognition of employee’s contributions and feedback on the results of their work, the recognition of their needs as parents and as individuals, and the fact that their department's management and their co-workers value them as people are all significant motivating factors. The aforementioned findings provide Greek policymakers with an effective instrument for enhancing the performance of public services.
Susceptibilidad antibiótica de bacterias presentes en piodermas de caninos (Canis lupus familiaris)
Authors: Cornejo Contreras Sandra Elizabeth , Campos Murillo Nathalie del Consuelo , Castillo Hidalgo Edy Paul 
Published: May 2023

Introducción: la resistencia bacteriana se ha incrementado en gran proporción al momento de tratar infecciones, y esto juega un papel de gran importancia ya que limita al veterinario al momento de realizar un tratamiento efectivo, por eso en estos casos es imprescindible el uso del antibiograma. Objetivo: el objetivo del presente estudio fue Identificar las bacterias encontradas en muestras de piodermas y su sensibilidad antibiótica en perros que asisten a consulta veterinaria en la ciudad de Cuenca, Metodología: se tomaron 60 muestras de pacientes de especie canina que lleguen a consulta en veterinarias en la ciudad mediante un hisopado de la lesión purulenta en pacientes que no han recibido antibióticos los últimos 3 días, y se realizó un cultivo y antibiograma. Resultados: de la población general correspondiente a 60 caninos se aislaron dos microorganismos: 6 muestras de Staphylococcus aureus representando el 10% del total de estudio de los cuales el Cefovecín sódico y la Azitromicina presentó el 100% de sensibilidad, el 66.67% de sensibilidad pertenecientes a la Levofloxacina, Amoxicilina, Amoxicilina + ácido clavulánico, Ciprofloxacina, Cefuroxima y Doxiciclina; mientras que, con un 33.33% de sensibilidad tenemos a la Cefalexina y Clindamicina; en las 54 muestras restantes se aisló Staphylococcus coagulasa negativa representando el 90% del estudio, obteniendo sensibilidad del 81.48% para Amoxicilina y amoxicilina + +ácido clavulánico, la Levofloxacina un 79.63%, en tercer lugar está la Ciprofloxacina y Cefuroxima con un porcentaje del 77.78%, seguidos con el 74.07% están la Cefalexina y Azitromicina, en el rango de 50 y 60% se encuentran el Cefovecin sódico, Clindamicina y Doxiciclina con el 64.81, y 59,26% respectivamente, mientras que, los antibióticos con la menor sensibilidad fueron la Penicilina y Oxacilina presentando un 7.41 y 0.00% de sensibilidad respectivamente. Conclusión: En el estudio no se encontró resistencia bacteriana al Cefovecin sódico frente a Staphylococcus aureus y S. coagulasa negativa. Los antibióticos con mayor porcentaje de resistencia bacteriana frente a Staphylococcus aureus y S. coagulasa negativa fueron la Penicilina y Oxacilina. Área de estudio: veterinaria, salud y bienestar animal.
Implementación del Geoportal para la Junta Administradora de Agua Potable y Saneamiento – JAAPyS - Santa Fé Centro, año 2023
Authors: Espín Morejón Maricela Araceli , Bonilla Manobanda Mónica Elizabeth , Medina Velasco Segundo Rafael , Vallejo Ballesteros Henry Fernando 
Published: May 2023

Introducción: en nuestro país se ha creado la respectiva legislación y los organismos de control que regula el trabajo de las Juntas Administradoras de Agua encargadas de la gestión del recurso hídrico, las mismas que deben gestionar elementos de infraestructura del sistema de agua potable (captaciones, redes de conducción, redes de distribución, válvulas de control, acometidas domiciliarias), información económica de cobros por consumo de agua, registro de usuarios (nuevos y cambio de beneficiarios), datos de fallos, reparaciones, ampliaciones de la infraestructura; sin embargo, debido a los limitados recursos económicos que manejan estas organizaciones es difícil que puedan prestar servicios de calidad, aprovechar de manera eficiente el recurso hídrico, garantizar la conservación de fuentes hídricas y la dotación del servicio de agua potable a todos los habitantes de la comunidad. Objetivos: apoyar al cumplimiento del sexto objetivo de la Agenda 2030 sobre el Desarrollo Sostenible aprobada por la ONU en 2015 Agua Limpia y Saneamiento, ha sido una preocupación de varias organizaciones a nivel mundial, entre ellas la FAO, UNESCO WWAP, PNUD, UNECE y UNEP, quienes se han propuesto ayudar a que se realice una eficiente gestión del recurso hídrico en beneficio de los usuarios; con este fin se utilizan las tecnologías digitales. Metodología: esta investigación es de tipo aplicada, con enfoque mixto, de campo y documental y descriptiva, para lo cual se estableció una metodología de recolección de datos técnicos sobre el comportamiento del recurso hídrico y las redes de distribución del sistema de agua potable. Resultados: metodología para levantar información para un sistema de agua potable, mapas de la infraestructura existente, listados actualizados de los usuarios y el geoportal utilizando software libre con información obtenida de la JAAP-S Santa Fé Centro. Conclusiones: la JAAP-S cuenta con un geoportal, en el cual los directivos fundamentalmente podrán visualizar los cambios que ocurran en los elementos de la infraestructura física del sistema de agua potable a través del tiempo. Área de estudio general: Software. Área de estudio específica: Sistemas de información geográfica.
PERENCANAAN STRUKTUR GEDUNG SHOWROOM KERAMIK LIMA LANTAI JALAN DR. CIPTO SEMARANG
Authors: ZHAFIRA TALITHA ZHAFIRA 
Published: May 2023

Struktur gedung yang direncanakan terdiri dari 5 lantai dengan panjang bangunan 29,350 m, lebar bangunan 23,203 m, dan tinggi bangunan 24,25 m. Struktur utama yang direncanakan meliputi rangka atap, plat lantai, plat tangga bordes, kolom, dan balok. Beban yang dihitung dalam perencanaan ini meliputi beban mati, beban hidup, dan juga beban gempa. Pemodelan struktur ini menggunakan bantuan program ETABS V.20 dan SP Column. Komponen gedung yang telah direncanakan dapat menahan gaya lentur, gaya geser, dan tentunya tahan gempa dengan menggunakan Metode Dinamik Respons Spektrum serta strukturalnya menggunakan Sistem Rangka Pemikul Momen Khusus (SRPMK). Hasil analisis ragam getar telah memenuhi standar peraturan, temuan analisis deviasi antara lantai arah X dan Y dinyatakan aman terhadap batas layan. Tinjauan nilai simpangan anatar lantai baik secara displacement maupun drift ratio memiliki nilai deviasi antar lantai yang lebih kecil dari deviasi izin. Hal ini menunjukkan bahwa struktur ini dapat menangani beban gempa yang telah direncanakan dan akan berkerja dengan baik saat menerima beban gempa jika suatu saat terjadi gempa bumi.
ANALISIS STRUKTUR DENGAN DINDING PENGISI DAN TANPA DINDING PENGISI PADA GEDUNG BERTINGKAT TERHADAP PERILAKU DINAMIK DENGAN METODE TIME HISTORY
Authors: CAHAYA TIARA , Islam Mukhlis , Afrizal Yuzuar , Wahyuni Ade Sri , Gunawan Agustin 
Published: May 2023

This study aims to compare structural modeling with the addition of wall elements and without walls with the help of SAP2000 software. The method used in this study is time history analysis using the San Fernando groundmotion data. Based on the modeling that has been done, the participation of the variance mass has reached 90% for structures with walls in mode 278 while without walls in mode 243. The addition of walls in this study resulted in a decrease in the drift value. The average percentage of settlement of each floor is 40.12% for the X direction and 30.26% for the Y direction. The addition of walls can also reduce the period value of the structure, where the structure with walls has a period value of 1.0804 seconds while the structure without walls is 1 ,2016 sec.

Keywords: Building Structure, Infill Wall, Drift, Time History Analysis