bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next‐Gen biotherapeutics: A systematic review and network meta‐analysis on postbiotics as treatment for pediatric atopic dermatitis
Authors: Tan Lim Carol Stephanie C. , Sajo Ma. Easter Joy V. , Orteza Khianne Ed Miguel P. , Fernandez Patricia Barbara A. , Vila Ma. Junella C. 
Published: September 2023

AbstractBackgroundDue to the recency of the postbiotic field, no head‐to‐head postbiotic studies have investigated its biotherapeutic potential for atopic dermatitis (AD). No network meta‐analysis (NMA) has been conducted to synthesize relevant studies comparing postbiotic interventions for AD.ObjectiveTo assess the comparative efficacy and safety of postbiotic strains in the treatment of pediatric AD.MethodologyThis was an NMA of randomized controlled studies that evaluated postbiotics in treating pediatric AD. Systematic search of databases and registers from inception to November 30, 2022. Three authors independently performed the search, screening, and appraisal using the Cochrane risk‐of‐bias tool version 2 and data extraction. Data analysis was performed using STATA14 software.ResultsNine studies evaluated eight postbiotic preparations. Lactobacillus rhamnosus IDCC 3201 (LR) ranked highest in the efficacy outcome. Compared to placebo, LR may be effective in reducing symptoms of atopic dermatitis in the main analysis (SMD −0.53, 95%CI −1.02 to −0.04) and sensitivity analysis involving studies that used SCORAD (MD −5.52, 95% CI −10.46 to −0.58), based on low‐certainty evidence. Based on moderate‐certainty evidence, LR probably did not increase the risk of adverse events (RR 0.97, 95% CI 0.79, 1.21). Although Lactobacillus paracasei GM080 (LP2) ranked highest in the safety outcome, it may not reduce AD symptoms compared to placebo (SMD −0.03, 95% CI −0.37, 0.32) based on low‐certainty evidence.ConclusionLR showed significant benefits in children with AD based on low‐certainty evidence. Further investigation of LR is recommended.
Experiential parts
Authors: Chuard Philippe 
Published: September 2023

AbstractSeveral disputes about the nature of experience operate under the assumption that experiences have parts, including temporal parts. There's the widely held view, when it comes to temporal experiences, that we should follow James' exhortation that such experiences aren't mere successions of their temporal parts, but something more. And there's the question of whether it is the parts of experiences which determine whole experiences and the properties they have, or whether the determination goes instead from the whole to the parts, as holists have it. But what are parts, or temporal parts, of experiences exactly—what does it mean to say that an experience is “part” of another? Are the participants in those disputes talking about the same thing—is there a univocal notion of “experiential part” available? Are there different kinds of experiential parts? And if there are, is there a systematic way of carving them out? More importantly, how should we conceive of the temporal parts of experiences, and how can we establish that experiences really do have temporal parts, against those who reject the notion?
Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
Authors: Quan Qing‐Ling , Yoon Kyeong‐No , Lee Ji Su , Kim Eun Ju , Lee Dong Hun 
Published: September 2023

AbstractBackground/PurposeUltraviolet (UV) radiation has both harmful and beneficial effects on human skin and health. It causes skin damage, aging, and cancer; however, it is also a primary source of vitamin D. Additionally, UV radiation can impact energy metabolism and has protective effects on several cardiovascular and metabolic disorders in mice and humans. However, the mechanisms of UV protection against these diseases have not been clearly identified.MethodsThis review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD) in mice, and we also consider the mechanisms of action of the related regulators nitric oxide (NO) and vitamin D.ResultsUV exposure can lower blood pressure and prevent the development of cardiovascular diseases and metabolic disorders, such as metabolic syndrome, obesity, and type 2 diabetes, primarily through mechanisms that depend on UV‐induced NO. UV radiation may also effectively delay the onset of type 1 diabetes through mechanisms that rely on UV‐induced vitamin D. UV‐induced NO and vitamin D play roles in preventing and slowing the progression of NAFLD.ConclusionUV exposure is a promising nonpharmacological intervention for cardiovascular and metabolic disorders. NO and vitamin D may play a crucial role in mediating these effects. However, further investigations are required to elucidate the exact mechanisms and determine the optimal dosage and exposure duration of UV radiation.
Analysis of the histidine kinase gene family and the role of GhHK8 in response to drought tolerance in cotton
Authors: Zhao Lanjie , Wang Yongbo , Cui Ruifeng , Cui Yupeng , Lu Xuke , Chen Xiugui , Wang Junjuan , Wang Delong , Yin Zujun , Wang Shuai , Peng Fanjia , Guo Lixue , Chen Chao , Ye Wuwei 
Published: September 2023

AbstractAs an important member of the two‐component system (TCS), histidine kinases (HKs) play important roles in various plant developmental processes and signal transduction in response to a wide range of biotic and abiotic stresses. So far, the HK gene family has not been investigated in Gossypium. In this study, a total of 177 HK gene family members were identified in cotton. They were further divided into seven groups, and the protein characteristics, genetic relationship, gene structure, chromosome location, collinearity, and cis‐elements identification were comprehensively analyzed. Whole genome duplication (WGD) / segmental duplication may be the reason why the number of HK genes doubled in tetraploid Gossypium species. Expression analysis revealed that most cotton HK genes were mainly expressed in the reproductive organs and the fiber at initial stage. Gene expression analysis revealed that HK family genes are involved in cotton abiotic stress, especially drought stress and salt stress. In addition, gene interaction networks showed that HKs were involved in the regulation of cotton abiotic stress, especially drought stress. VIGS experiments have shown that GhHK8 is a negative regulatory factor in response to drought stress. Our systematic analysis provided insights into the characteristics of the HK genes in cotton and laid a foundation for further exploring their potential in drought stress resistance in cotton.
Insight into the nodal cells transcriptome of the streptophyte green alga Chara braunii S276
Authors: Heß Daniel , Holzhausen Anja , Hess Wolfgang R. 
Published: September 2023

AbstractCharophyceae are the most complex streptophyte algae, possessing tissue‐like structures, rhizoids and a cellulose‐pectin‐based cell wall akin to embryophytes. Together with the Zygnematophyceae and the Coleochaetophycae, the Charophyceae form a grade in which the Zygnematophyceae share a last common ancestor with land plants. The availability of genomic data, its short life cycle, and the ease of non‐sterile cultivation in the laboratory have made the species Chara braunii an emerging model system for streptophyte terrestrialization and early land plant evolution. In this study, tissue containing nodal cells was prepared under the stereomicroscope, and an RNA‐seq dataset was generated and compared to transcriptome data from whole plantlets. In both samples, transcript coverage was high for genes encoding ribosomal proteins and a homolog of the putative PAX3‐ and PAX7‐binding protein 1. Gene ontology was used to classify the putative functions of the differently expressed genes. In the nodal cell sample, main upregulated molecular functions were related to protein, nucleic acid, ATP‐ and DNA binding. Looking at specific genes, several signaling‐related genes and genes encoding sugar‐metabolizing enzymes were found to be expressed at a higher level in the nodal cell sample, while photosynthesis‐and chloroplast‐related genes were expressed at a comparatively lower level. We detected the transcription of 21 different genes encoding DUF4360‐containing cysteine‐rich proteins. The data contribute to the growing understanding of Charophyceae developmental biology by providing a first insight into the transcriptome composition of Chara nodal cells.
Associations of early life and childhood risk factors with obstructive sleep apnoea in middle‐age
Authors: Senaratna Chamara V. , Lowe Adrian , Walters E. Haydn , Abramson Michael J. , Bui Dinh , Lodge Caroline , Erbas Bircan , Burgess John , Perret Jennifer L. , Hamilton Garun S. , Dharmage Shyamali C. 
Published: September 2023

AbstractBackground and ObjectiveEarly‐life risk factors for obstructive sleep apnoea (OSA) are poorly described, yet this knowledge may be critical to inform preventive strategies. We conducted the first study to investigate the association between early‐life risk factors and OSA in middle‐aged adults.MethodsData were from population‐based Tasmanian Longitudinal Health Study cohort (n = 3550) followed from 1st to 6th decades of life. Potentially relevant childhood exposures were available from a parent‐completed survey at age 7‐years, along with previously characterized risk factor profiles. Information on the primary outcome, probable OSA (based on a STOP‐Bang questionnaire cut‐off ≥5), were collected when participants were 53 years old. Associations were examined using logistic regression adjusting for potential confounders. Analyses were repeated using the Berlin questionnaire.ResultsMaternal asthma (OR = 1.5; 95% CI 1.1–2.0), maternal smoking (OR = 1.2; 1.05, 1.5), childhood pleurisy/pneumonia (OR = 1.3; 1.04, 1.7) and frequent bronchitis (OR = 1.2; 1.01, 1.5) were associated with probable OSA. The risk‐factor profiles of ‘parental smoking’ and ‘frequent asthma and bronchitis’ were also associated with probable OSA (OR = 1.3; 1.01, 1.6 and OR = 1.3; 1.01–1.9, respectively). Similar associations were found for Berlin questionnaire‐defined OSA.ConclusionsWe found novel temporal associations of maternal asthma, parental smoking and frequent lower respiratory tract infections before the age of 7 years with adult OSA. While determination of their pathophysiological and any causal pathways require further research, these may be useful to flag the risk of OSA within clinical practice and create awareness and vigilance among at‐risk groups.
Counterfactual thinking may attenuate polarization of COVID‐19 prevention behavior
Authors: García Ferrés Eva A. , DePalma Mary Turner 
Published: September 2023

AbstractData from two U.S. online samples (N = 613) indicated that conservatives consistently perceived face mask use as less important than did liberals. This difference was attenuated with high counterfactual engagement. Both studies provide correlational evidence of this robust moderation. Study 2 provides further insight into differences between liberals' and conservatives' emotional responses to COVID‐19 information, and suggests that during on‐going negative events, downward counterfactuals may not provide relief. Overall, these studies document the politicization of public health behavior, and find that emphasizing the causal links between behavior and COVID‐19 prevention may improve conservatives' attitudes toward CDC guidelines.
Disadvantaged and Disadvantaging Regions: Opportunity Structures and Social Disadvantage in Rural Peripheries
Authors: Bernard Josef , Keim‐Klärner Sylvia 
Published: September 2023

AbstractRegional peripheralisation has been repeatedly described as a process resulting in the combination of regional structural and social disadvantage. In theory, peripheries are characterised by the interdependence of these two types of disadvantage. Few studies have examined this interdependence in rural peripheries across several countries. In this study, we operationalise rural peripherality combining poor opportunity structures that constrain the social and economic opportunities of the local population, and increased concentrations of social disadvantage and decreased quality of life. Comparing Czech and eastern German regions, we uncovered intercorrelated spatial patterns of low education, poor employment quality, deficient labour market opportunity and accessibility to medical, educational and other services, which together represent key aspects of rural peripherality from the perspective of disadvantage. Although there is a clear coincidence of structural and social disadvantage in rural peripheries, neither increased levels of poverty nor long‐term unemployment are typical of these areas.
OPEN leaf: an open‐source cloud‐based phenotyping system for tracking dynamic changes at leaf‐specific resolution in Arabidopsis
Authors: Swartz Landon G. , Liu Suxing , Dahlquist Drew , Kramer Skyler T. , Walter Emily S. , McInturf Samuel A. , Bucksch Alexander , Mendoza‐Cózatl David G. 
Published: September 2023

SUMMARYThe first draft of the Arabidopsis genome was released more than 20 years ago and despite intensive molecular research, more than 30% of Arabidopsis genes remained uncharacterized or without an assigned function. This is in part due to gene redundancy within gene families or the essential nature of genes, where their deletion results in lethality (i.e., the dark genome). High‐throughput plant phenotyping (HTPP) offers an automated and unbiased approach to characterize subtle or transient phenotypes resulting from gene redundancy or inducible gene silencing; however, access to commercial HTPP platforms remains limited. Here we describe the design and implementation of OPEN leaf, an open‐source phenotyping system with cloud connectivity and remote bilateral communication to facilitate data collection, sharing and processing. OPEN leaf, coupled with our SMART imaging processing pipeline was able to consistently document and quantify dynamic changes at the whole rosette level and leaf‐specific resolution when plants experienced changes in nutrient availability. Our data also demonstrate that VIS sensors remain underutilized and can be used in high‐throughput screens to identify and characterize previously unidentified phenotypes in a leaf‐specific time‐dependent manner. Moreover, the modular and open‐source design of OPEN leaf allows seamless integration of additional sensors based on users and experimental needs.
Dynamic transcriptome landscape of developing maize ear
Authors: Shen Xiaomeng , Xiao Bing , Kaderbek Tangnur , Lin Zhen , Tan Kaiwen , Wu Qingyu , Yuan Lixing , Lai Jinsheng , Zhao Haiming , Song Weibin 
Published: September 2023

SUMMARYSeed number and harvesting ability in maize (Zea mays L.) are primarily determined by the architecture of female inflorescence, namely the ear. Therefore, ear morphogenesis contributes to grain yield and as such is one of the key target traits during maize breeding. However, the molecular networks of this highly dynamic and complex grain‐bearing inflorescence remain largely unclear. As a first step toward characterizing these networks, we performed a high‐spatio‐temporal‐resolution investigation of transcriptomes using 130 ear samples collected from developing ears with length from 0.1 mm to 19.0 cm. Comparisons of these mRNA populations indicated that these spatio‐temporal transcriptomes were clearly separated into four distinct stages stages I, II, III, and IV. A total of 23 793 genes including 1513 transcription factors (TFs) were identified in the investigated developing ears. During the stage I of ear morphogenesis, 425 genes were predicted to be involved in a co‐expression network established by eight hub TFs. Moreover, 9714 ear‐specific genes were identified in the seven kinds of meristems. Additionally, 527 genes including 59 TFs were identified as especially expressed in ear and displayed high temporal specificity. These results provide a high‐resolution atlas of gene activity during ear development and help to unravel the regulatory modules associated with the differentiation of the ear in maize.
Proteomes reveal the lipid metabolic network in the complex plastid of Phaeodactylum tricornutum
Authors: Huang Teng , Pan Yufang , Maréchal Eric , Hu Hanhua 
Published: September 2023

SUMMARYPhaeodactylum tricornutum plastid is surrounded by four membranes, and its protein composition and function remain mysterious. In this study, the P. tricornutum plastid‐enriched fraction was obtained and 2850 proteins were identified, including 92 plastid‐encoded proteins, through label‐free quantitative proteomic technology. Among them, 839 nuclear‐encoded proteins were further determined to be plastidial proteins based on the BLAST alignments within Plant Proteome DataBase and subcellular localization prediction, in spite of the strong contamination by mitochondria‐encoded proteins and putative plasma membrane proteins. According to our proteomic data, we reconstructed the metabolic pathways and highlighted the hybrid nature of this diatom plastid. Triacylglycerol (TAG) hydrolysis and glycolysis, as well as photosynthesis, glycan metabolism, and tocopherol and triterpene biosynthesis, occur in the plastid. In addition, the synthesis of long‐chain acyl‐CoAs, elongation, and desaturation of fatty acids (FAs), and synthesis of lipids including TAG are confined in the four‐layered‐membrane plastid based on the proteomic and GFP‐fusion localization data. The whole process of generation of docosahexaenoic acid (22:6) from palmitic acid (16:0), via elongation and desaturation of FAs, occurs in the chloroplast endoplasmic reticulum membrane, the outermost membrane of the plastid. Desaturation that generates 16:4 from 16:0 occurs in the plastid stroma and outer envelope membrane. Quantitative analysis of glycerolipids between whole cells and isolated plastids shows similar composition, and the FA profile of TAG was not different. This study shows that the diatom plastid combines functions usually separated in photosynthetic eukaryotes, and differs from green alga and plant chloroplasts by undertaking the whole process of lipid biosynthesis.
Regional integration and services in African value chains: Retrospect and prospect
Authors: Shepherd Ben 
Published: September 2023

AbstractThis article takes a first step towards understanding the quantitative evidence on the role of services in African value chains. The available data are largely based on assumptions and modelled estimates, but can nonetheless provide some useful information at an aggregate level. In general, services play an important role in the African regional economy, including through their embodiment in the exports of other sectors through input–output relationships. However, services value chains in the region are mostly composed of domestic value added, and to a lesser extent inputs sourced from global suppliers. There is very little intra‐regional sourcing of services inputs. Simulations using a new quantitative trade model show that intra‐regional sourcing could be increased through a derived demand effect following goods market liberalisation. In the stylized cases examined, increased use of regional services inputs is not at the expense of globally competitive suppliers. As such, it will be important to give a more prominent role to services in discussions of regional integration going forward.
Use of administrative claims data in observational studies of antirheumatic medication effects on pregnancy outcomes: a scoping review protocol
Authors: Tharmarajah Shenthuraan , Guilcher Sara , Santhireswaran Araniy , McCarthy Lisa , Mahendira Dharini , Berger Howard , Tadrous Mina 
Published: September 2023

Objective:
The primary objective of this review is to examine which disease-modifying antirheumatic drugs (DMARDs) and biologics used to treat pregnant individuals with rheumatic conditions have been reported in observational studies using population-based health administrative data. The secondary objective is to describe which adverse pregnancy outcomes (both maternal and neonatal) have been reported, their definitions, and corresponding diagnostic and/or procedural codes.

Introduction:
Pregnant individuals are typically excluded from drug trials due to unknown potential risks to both the pregnant person and fetus, leaving most antirheumatic drugs understudied for use in pregnancy. Despite these substantial knowledge gaps, most pregnant individuals continue to be maintained on antirheumatic medications due to the benefits generally outweighing the risks. In contrast to previous systematic reviews of findings from randomized trials, our scoping review aims to leverage this real-world data to generate real-world evidence of antirheumatic drug safety during pregnancy.

Inclusion criteria:
Articles must report on observational studies using population-based health administrative data from pregnant individuals with rheumatic conditions (rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and psoriatic arthritis) receiving antirheumatic drug therapy (DMARDs and biologics). Randomized trials, reviews, case studies, opinion pieces, and abstracts will be excluded.

Methods:
Electronic databases (MEDLINE [Ovid], Embase [Ovid], CINAHL [EBSCOhost]) and gray literature (OpenGrey, Health Services Research Projects in Progress, World Health Organization Library, and Google Scholar) will be searched for relevant evidence. Search terms will combine 4 concepts: rheumatic diseases, drug therapy, pregnancy, and health care administrative data. Identified articles will be independently screened, selected, and extracted by 2 researchers. Data will be analyzed descriptively and presented in tables.

Review registration:
Open Science Framework https://osf.io/5e6tp
Significant Changes in Resting Metabolic Rate Over a Competitive Match Week Are Accompanied by an Absence of Nutritional Periodization in Male Professional Soccer Players
Authors: Carter Jennie L. , Lee David J. , Perrin Craig G. , Ranchordas Mayur K. , Cole Matthew 
Published: September 2023

Resting metabolic rate (RMR) is an important component of total daily energy expenditure; however, it is currently not understood how it varies across a typical competitive match week in professional soccer players. For the first time, we aimed to assess RMR throughout an in-season competitive week in professional soccer players. Additionally, we aimed to assess energy and carbohydrate intake across the same week. Twenty-four professional soccer players from an English Premier League club (age: 18 ± 1.6 years) completed the study. RMR was assessed each morning of a typical competitive match week (match day [MD] −3, −2, −1, +1, +2, and + 3), and dietary intake (including MD) was assessed daily via the remote food photography method and 24-hr recall. Daily training load was quantified using Global Positioning System, daily muscle soreness ratings were recorded, and body composition was assessed via dual-energy X-ray absorptiometry. There was a significant (p = .0004) increase in mean RMR of ∼261 kcal/day on MD + 1, compared with MD − 1. Additionally, volume of oxygen consumed significantly increased at MD + 1 (p = .0002) versus MD − 1. There were no significant differences in daily energy or carbohydrate intake across the competitive week (p > .05), with inadequate carbohydrate intakes on MD − 1 (∼3.9 g/kg body mass), MD (∼4.2 g/kg body mass), and MD + 1 (∼3.6 g/kg body mass) in relation to current recommendations. We report, for the first time, that RMR is significantly increased following a competitive match in professional soccer players. In addition, we confirm previous findings to reinforce that players exhibit inadequate nutrition periodization practices, which may impair physical performance and recovery.