bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproductive cancer cryopreservation services: Patient information, clinical advice, and support
Authors: Mocanu Edgar , Purandare Nikhil C. , Hull Louise 
Published: January 2025

AbstractFertility preservation services must offer information to patients, prior to their visit, so that they have time to read and digest the information, and also have the opportunity to write down any questions they wish to ask at the oncofertility consultation appointment. Appointments must be offered immediately, based on a specifically designed referral form. Each fertility service providing oncology cryopreservation should have a robust map of the patient's journey to include referral, counseling session, medical consultation, informed consent, treatment plan, and follow‐up. Consent for fertility preservation should only be obtained after thorough assessment and discussion with the patient. It must contain basic aspects such as duration of storage, right to dispose or choose alternatives, wishes about stored material if death occurs, and need for patient contact on an annual basis. Appropriate legal advice should be sought in the process of establishing oncology cryopreservation services, most importantly related to patient consent. Ethical and legal aspects of fertility cryopreservation must be considered in the provision of care for cancer patients. Cancer patients attending for cryopreservation have significant concerns in relation to the success of the process, time frame to return for cancer treatment, and safety. Two major nonmedical aspects, coping ability and mortality, are best addressed by counselors and highlight the need to offer this type of psychological support to all cancer patients attending for fertility preservation. The role of genetic counseling is to discuss any potential risks of transmission of the disease to the resulting offspring and offer genetic testing when appropriate. A service based on availability of comprehensive information coupled with in‐house implications counseling will have a positive impact and improve the overall care of patients attending for fertility cryopreservation and this should be standard care.
Fertility preservation in female cancer patients: Surgical procedures
Authors: Roopnarinesingh Rishi , Tulandi Togas 
Published: January 2025

AbstractThe surgical management of cancer patients wishing fertility preservation is multidisciplinary, involving surgeon, anesthetist, hematologist, and nursing and laboratory staff. Many oncology patients have a multitude of medical or surgical conditions that require careful planning of all therapy including surgical removal of reproductive material, either oocytes or ovarian tissue. The significant risks related to either transvaginal or abdominal surgery should be discussed and documented and the final decision to proceed must be balanced against the risks, including death. Multidisciplinary communication for individual case management is the safeguard for patient safe return to cancer therapy.
Verticutting frequency influences lateral spread of two Paspalum species
Authors: Henry G. M. , Johnston C. R. , Tucker K. A. 
Published: January 2025

AbstractBahiagrass (Paspalum notatum Flüggé) and dallisgrass (Paspalum dilatatum Poir.) are perennial warm‐season grasses that readily invade home lawns, sports fields, and golf courses. Research was conducted at the Athens Turfgrass Research and Education Center in Athens, GA, during the summer of 2015 to evaluate the response of Paspalum L. species to verticutting. Weeds were transplanted into bare ground from naturally occurring populations and allowed to mature for 3 weeks prior to trial initiation. Treatments were arranged in a factorial design with two Paspalum L. species by four verticutting treatments in a split‐plot experimental design with four replications. The main plot factor was verticutting treatment (no verticutting, one verticutting event, two verticutting events, and three verticutting events). The subplot factor was Paspalum L. species (bahiagrass or dallisgrass). Verticutting had a negative impact on bahiagrass lateral spread, while dallisgrass responded similarly to verticutting as the non‐verticut check. Significant reductions in bahiagrass plant diameter were observed following two and three verticutting events. The asymmetric response of Paspalum L species to verticutting may be attributed to plant morphology. Bahiagrass rhizomes run along the soil surface, making them susceptible to mechanical damage from verticutting, while dallisgrass rhizomes are protected belowground within the soil profile. Although verticutting alone does not control bahiagrass, the incorporation of verticutting into a bahiagrass chemical control program may improve long‐term control by garnering the benefits of both mechanical damage and enhanced herbicidal activity.
Allelopathic potential of cool‐season turfgrass species as an alternative management strategy for weed control
Authors: Amgain Naba R. , Patton Aaron J. , Liu Wenwen , Cain Alyssa , Kowalewski Alec , Askew Shawn D. , Goncalves Clebson Gomes , Bagavathiannan Muthukumar , Taylor J. W. , McCarty L. B. 
Published: January 2025

AbstractHerbicides are a common input in turfgrass systems. Selecting turfgrass species that have either the ability to out‐compete weeds or inhibit their germination and establishment is a primary integrated weed management strategy to reduce herbicide use. The objective of this experiment was to assess the allelopathic potential of common cool‐season turfgrass species (Festuca arundinacea, Festuca brevipila, Festuca rubra ssp. rubra, Festuca rubra ssp. littoralis, Festuca rubra ssp. commutata, Lolium perenne, and Poa pratensis) on common turf weeds (Digitaria sanguinalis, Eleusine indica, Poa annua, and Taraxacum officinale). Greenhouse and laboratory experiments were conducted to evaluate the effect of turfgrass competition, leaf extracts, and soil leachates on the germination and growth of weed species. Leaf extracts and soil leachates of turfgrass species generally had more effect on radicle growth than on germination and coleoptile (or hypocotyl) growth. Cool‐season turfgrass leaf extracts did not suppress the gemination of P. annua, D. sanguinalis, or E. indica. P. pratensis leaf extracts were effective in suppressing Taraxacum officinale germination and emergence. Poa annua emergence and development were significantly lower when seeded into dense, established cool‐season turfgrasses. All turfgrass species were equally inhibitory when the turf was dense and competition was present. Limited allelopathic effects were noted in this experiment. Rather than picking a turfgrass species for potential allelopathic effects, these results point to the more effective weed management strategy of maintaining a dense and robust turf sward capable of outcompeting weeds for light, nutrients, and water.
TFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway
Authors: Shen Kai , Shan Zhidong , Li Yingjie , Ji Zeyi , Zhou Luyao , Lv Zhiliang 
Published: January 2025

ABSTRACTAs the most prevalent subtype of lung cancer, lung adenocarcinoma (LUAD) is closely associated with angiogenesis, which is fundamental to its progression. ADAM8 (A disintegrin and metalloproteinase 8) is an enzyme associated with tumor invasion, while its implications in LUAD angiogenesis are a field that awaits exploration. A thorough investigation into the impacts of ADAM8 on LUAD angiogenesis could contribute to the development of therapeutic drugs for LUAD. Bioinformatics delineated the expression profiles of TFAP2A and ADAM8 in LUAD tissues, focusing on ADAM8‐enriched pathways. qRT‐PCR confirmed their expression in LUAD cells. The CCK‐8 assay was applied to gauge cell viability, and Western blot detected the presence of JAK2/STAT3 pathway proteins and VEGFR‐2 and VEGF. Angiogenesis assays quantified the length of angiogenesis, and dual‐luciferase and Chromatin immunoprecipitation assays verified the TFAP2A‐ADAM8 binding. ADAM8 exhibited high expression in LUAD tissues and cells, with notable enrichment in the VEGF and JAK/STAT pathways. Cellular assays revealed that elevated ADAM8 expression enhanced cell viability, promoted the phosphorylation of JAK2 and STAT3, and boosted angiogenic capacity. The JAK inhibitor Peficitinib reversed the proangiogenic effects induced by ADAM8 overexpression. We also discovered overexpression of TFAP2A, an upstream transcription factor of ADAM8, in LUAD. Rescue experiments indicated that ADAM8 overexpression could counteract the inhibitory effects of TFAP2A knockdown on LUAD angiogenesis. This study reveals for the first time the critical role of ADAM8 in LUAD angiogenesis, demonstrating that TFAP2A promotes JAK/STAT pathway conduction by activating ADAM8. This finding not only provides a new perspective for understanding the pathogenesis of LUAD but also lays the foundation for the development of new therapies targeting ADAM8.
Design, Synthesis, and In Vitro Evaluation of Aromatic Sulfonamides as Human Carbonic Anhydrase I, II, IX, and XII Inhibitors and Their Antioxidant Activity
Authors: Abha Mishra KM , Kumari Nutan , Carta Fabrizio , Renzi Gioele , Supuran Claudiu T. , Sethi Kalyan K. 
Published: January 2025

ABSTRACTThis study is focused on the design, synthesis, and evaluation of some sulfonamide derivatives for their inhibitory effects on human carbonic anhydrase (hCA) enzymes I, II, IX, and XII as well as for their antioxidant activity. The purity of the synthesized molecules was confirmed by the HPLC purity analysis and was found in the range of 93%–100%. The inhibition constant (Ki) against hCA I ranged from 0.75 nM to 1972 nM. The sulfonamides inhibited isoform hCA II significantly, with a Ki ranging from 0.09 to 56 nM. Similarly, the inhibitory effects on hCA IX and XII were found with Ki spanning from 27.8 to 2099 nM and 9.43 to 509 nM, respectively. Most of the synthesized compounds showed significant inhibition in comparison to standard drugs such as acetazolamide, ethoxzolamide, zonisamide, methazolamide, dorzolamide, and SLC‐0111. Antioxidant activity was assessed using the DPPH assay, with compound 13 showing better antioxidant activity with an IC50 of 54.8 µg/mL, as compared to the standard ascorbic acid (IC50 64.7 µg/mL). The molecular docking studies provided insights into the binding modes of these compounds. The in silico physicochemical properties, pharmacokinetic/ADME, and toxicity properties evaluations confirmed favorable drug‐likeness properties, complying with Lipinski's rule. These findings underscore the therapeutic potential of these compounds for the treatment of retinal/cerebral edema, glaucoma, edema, epilepsy management, high‐altitude sickness, and cancer.
Potential Correlation Between Hematological Parameters and Palpitation in Outpatients With COVID‐19: A Retrospective Study
Authors: Zhang Lei , Chen Ting , Wei Ling , Ren Juan , Gong Jing , Yuan Hui , Liu QingJun 
Published: January 2025

ABSTRACTBackgroundResearch on heart injury caused by COVID‐19 is limited to large observational and retrospective cohort studies using imaging or pathological data. Reported changes in the levels of myocardial markers in severe diseases have been limited, with few studies on mild infections. The effects of COVID‐19 on cardiac function and changes in myocardial marker levels have not yet been reported.MethodsWe analyzed data from outpatient blood samples collected at Beijing Anzhen Hospital during the 2022 COVID‐19 outbreak and used the same periods in 2020 and 2021 as controls, focusing on changes in routine blood tests, coagulation, myocardial markers, and other blood indices in patients with palpitations.ResultsThe number of patients with palpitations increased by 4.87‐fold during the COVID‐19 mass outbreak in 2022. The indices of myocardial damage did not show any symptom‐related increases but decreased within the normal range. The proportion of patients with palpitations whose D‐dimer and fibrinogen/fibrin degradation product (FDP) values exceeded the reference ranges increased, as did the numbers of neutrophils, monocytes, and platelets. In this retrospective analysis, we found little change in the myocardial markers in patients with mild COVID‐19.ConclusionsIn patients with mild COVID‐19, attention should be diverted from detecting myocardial markers to changes in coagulation test results, focusing on the levels of coagulation indices to improve circulation and prevent thrombosis.
One‐stage revision anterior cruciate ligament reconstruction: Preoperative evaluation, planning and surgical techniques. A review of current concepts
Authors: Giannakis Periklis , Zhuang Sophia T. , Rosenstadt Jacob L. , Marx Robert G. 
Published: January 2025

AbstractThe increased rate of anterior cruciate ligament (ACL) tears has led to a greater number of revisions. Revision surgery can be performed in one or two stages. Single‐stage revision ACL reconstruction (ssRACLR) may be performed when prior tunnels can be re‐used or bypassed whereas a two‐stage procedure is indicated when bone grafting of dilated tunnels prior to revision is necessary. While both approaches have shown similar functional outcomes and failure risk, ssRACLR is preferred, when possible, to avoid the increased morbidity, inconvenience and cost associated with two‐stage RACLR. In adequately planning for RACLR, a surgeon should investigate the mechanism and timing of injury as well as the previous graft selection, associated pathology and the tunnel placement and size. It is especially important to obtain radiographs and three‐dimensional imaging including magnetic resonance imaging (MRI) and computed tomography (CT), which allow the surgeon to accurately evaluate the entire tunnel architecture to determine surgical staging. Following a detailed assessment of the pathoanatomy, the surgeon may determine graft and hardware type, tunnel placement and utilization of lateral extra‐articular tenodesis (LET) and other procedures. In our experience, ssRACLR can be carried out for over 90% of revision cases with creative pre‐operative planning using autograft with bone plug(s), divergent tunnel creation on the femur (when necessary) and convergent tunnel creation on the tibia (when appropriate) and suspensory or interference fixation as needed. In revision scenarios, we believe that autografts with bone plugs provide the best opportunity for graft healing and incorporation and that LET can be a useful adjunct to reduce re‐tear rates. The purpose of this review is to report on the preoperative considerations and surgical techniques for performing ssRACLR, as well as the outcomes.Level of EvidenceLevel V expert opinion.
Long‐Term Clinical Outcomes After Autologous Hematopoietic Stem Cell Transplantation in 49 Individuals Living With HIV (PLWH) and Affected by High‐Risk or Relapsed Lymphoma: A European Experience of Continued Relevance for PLWH
Authors: Zanet Ernesto , Taborelli Martina , Tirelli Umberto , Diez‐Martin Jose , Balsalobre Pascual , Re Alessandro , Rupolo Maurizio , Mazzucato Mario , Cwynarski Kate , Gomez Maria Rosario Varela , Guillerm Gaelle , Serraino Diego , Ciancia Rosanna , Chirumbolo Salvatore , Carbone Antonino , Michieli Mariagrazia 
Published: January 2025

ABSTRACTPrevious reports have indicated that during the era of combination antiretroviral therapy, the major causes of morbidity and mortality in people living with HIV (PLWH) were not solely linked to HIV‐related opportunistic infections but also to cancers that were difficult to manage due to HIV‐related immunodeficiency. We investigated whether PLWH who underwent autologous hematopoietic stem cell transplantation (ASCT) for lymphomas experienced significant morbidity over the past thirty years following HIV infection. We conducted a retrospective follow‐up study of 49 PLWH over a 10‐year period following ASCT. We collected survival data, examined the occurrence of long‐term events, assessed CD4 + T‐cell immune recovery, and analysed the correlation between immune recovery and the events experienced by these patients. The data confirmed the significant long‐term effectiveness of ASCT, with an overall survival rate of 78% at 10 years post‐ASCT. Opportunistic infections, which occurred soon after ASCT and were associated with lower CD4 + T‐cell counts, were successfully managed. However, lymphoma relapse, secondary malignancies, cardiovascular disease, and bone disease, which developed years after ASCT, were major causes of morbidity and mortality in this population. Our findings highlight the need for the development and validation of specific tests to predict risk and guide effective interventions for metabolic diseases, secondary malignancies, and lymphoma relapses in PLWH treated with ASCT for lymphoma.
TikTok and Online Dating: A Social Media Analysis of Emerging Patterns
Authors: Balcioglu Yavuz Selim , Cerasi Ceren Cubukcu 
Published: January 2025

ABSTRACTInternet dating is becoming a more common practice in modern societies and social media plays an important role in shaping social interactions and cultural discourse. In this study, TikTok data will be analyzed to explore the online dating potential of TikTok users in Turkey. The study highlights the importance of understanding communication strategies on social media, especially in the context of dating and relationships. Using a structured methodology, it was aimed to gain a comprehensive understanding of how TikTok is used in the context of dating in Turkey, investigating both content creation patterns and audience participation in these topics. The findings show that dating and interpersonal relationships on TikTok are not just personal; they are deeply connected to cultural norms, societal expectations, and digital communication trends. The study provides valuable information for the development of communication strategies on social media, especially focusing on dating and interpersonal relationships. In conclusion, this study underlines the need to further investigate the relationship between social media and interpersonal communication, especially in the context of evolving digital environments.
Dual‐protein system composed of soy protein and β‐lactoglobulin: effect of transglutaminase‐mediated crosslinking on its allergenicity and conformation
Authors: Xing Guangliang , Liu Jia , Tang Ruyi , Hui Tianran 
Published: January 2025

AbstractBACKGROUNDThe escalating global prevalence of food allergies has intensified the need for hypoallergenic food products. Transglutaminase (TGase)‐mediated crosslinking has garnered significant attention for its potential to reduce the allergenicity of food proteins. This study aimed to investigate the effects of TGase crosslinking on the potential allergenicity and conformational changes in a dual‐protein system composed of β‐lactoglobulin (β‐LG) and soy protein isolate (SPI) at varying mass ratios (10:0, 7:3, 5:5, 3:7 and 0:10 (w/w)).RESULTSTGase preferentially crosslinked the 7S and 11S subunits of soy protein, rather than β‐LG. Crosslinking treatment reduced the allergenic potential of both soy protein and β‐LG, with the degree of reduction depending on the protein ratio. The β‐LG5:SPI5 and β‐LG7:SPI3 mixtures showed the most significant reduction in antibody reactivity towards soy protein and β‐LG, respectively. Additionally, TGase‐mediated crosslinking significantly reduced the binding capacity of all dual‐protein samples to serum immunoglobulin E from allergic patients, compared to the control group (P < 0.05). The allergenicity reduction was accompanied by structural modifications, including a decrease in β‐sheet content, an increase in β‐turn and random coil structures, enhanced ultraviolet absorption and intrinsic fluorescence, reduced free sulfhydryl levels and altered intermolecular forces. These changes suggest that TGase‐induced crosslinking may disrupt or mask allergenic epitopes, thus lowering allergenicity.CONCLUSIONTGase crosslinking effectively reduced the allergenic potential of the dual‐protein system by inducing structural changes. These findings underscore the potential of TGase in developing hypoallergenic dual‐protein food products and provide a scientific foundation for future research and application in the food industry. © 2025 Society of Chemical Industry.
Antithrombotic use in retinal artery occlusion: A narrative review
Authors: Liu Wan‐Yu , Tang Yun‐Hsin , Chen Yi‐Hsing 
Published: January 2025

AbstractRetinal artery occlusion (RAO) is a critical ophthalmic emergency with a high risk of significant visual impairment. While traditional treatment aims to promptly restore blood flow to the retina, recent research has investigated the potential benefits of anticoagulation therapy for managing this condition. This paper reviews current literature and clinical trials investigating the efficacy and safety of anticoagulant and antiplatelet therapies, such as systemic heparinization and direct oral anticoagulants and aspirin, in treating RAO. The mechanism of action involves preventing thrombus propagation and platelet aggregation to promote microvascular circulation, potentially mitigating ischemic damage and improving visual outcomes. However, controversies exist regarding the optimal timing, duration, and selection of antithrombotic agents due to the risk of hemorrhagic complications. Further large‐scale prospective studies are warranted to establish evidence‐based guidelines for incorporating antithrombotic into the standard management of RAO. This paper underscores the evolving landscape of antithrombotic therapy as a promising adjunctive treatment strategy in the management of retinal artery occlusion.
Consequences of Land Utilization, Agriculture and Water to Handle the Food Security Issues
Authors: Sarwar Suleman 
Published: January 2025

ABSTRACTThe study focuses on the intricate dynamic of agricultural value‐added, water reservoir management, and food security in the United States between 1980 and 2021. The importance of agricultural value‐added in food security is examined in this study, which adds to the current literature. Furthermore, the study examines how food security is impacted by economic growth, land use, innovation, and efficient water management. According to the findings, the enhancement of food security is significant due to increased agricultural productivity, driven by value‐added practices, and robust water reservoir management. The study demonstrates the connection between economic growth and better food security, emphasizing the significance of sustainable economic policies. Efficient land use and technological innovations in agriculture can be used to ensure food supply stability. The research has revealed that water reservoirs have a moderating effect, demonstrating their significance in sustaining agricultural productivity and value‐added activities. These insights are crucial for policymakers and practitioners, suggesting that a holistic approach, integrating economic, agricultural, and environmental strategies, is essential for addressing the multifaceted challenges of food security in the United States. A contemporary perspective is provided through the study's time frame, reflecting recent trends and policy implications in food security.
Featured Front Cover
Authors: Koenig Xavier G. H. , Deenapanray Prakash N. K. , Weber Jean‐Louis , Rakotondraompiana Solofo , Ramihangihajason Tony Arison 
Published: January 2025

The cover image is based on the article Are Neutrality Targets Alone Sufficient for Protecting Nature? Learning From Land Cover Change and Land Degradation Neutrality Targets in Mauritius by Xavier Koenig et al., https://doi.org/10.1002/ldr.5359.
image