bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutta: a novel tool for E2E web mutation testing
Authors: Leotta Maurizio , Paparella Davide , Ricca Filippo 
Published: April 2023

AbstractMutation testing is an important technique able to evaluate the bug-detection effectiveness of existing software test suites. Mutation testing tools exist for several languages, e.g., Java and JavaScript, but no solutions are available for managing the mutation testing process for entire web applications, in the context of end-to-end (E2E) web testing. In this paper, we propose Mutta, a novel tool able to automate the entire mutation testing process. Mutta mutates the various server source files of the target web application, runs the E2E test suite against the mutated web applications, and finally collects the test outcomes. To evaluate Mutta, we designed a case study using the mutated versions of the target web application with the aim of comparing the effectiveness of two different approaches to E2E web testing: (1) test cases based on classical assertions and (2) test cases relying on differential testing. In detail, Mutta has been executed on two web applications, each equipped with different test suites to compare assertions with differential testing. In this scenario, Mutta generated a large number of mutants (more than 15k overall), took into account the coverage information to consider only the mutants actually executed, deployed the mutated web app, ran the entire E2E test suites (about 87k tests runs overall), and finally, it correctly saved the test suite results. Thus, results of the case study show that Mutta can be successfully employed to automate the entire mutation testing process of E2E web test suites and, therefore, can be used in practice to evaluate the effectiveness of different test suites (e.g., based on different techniques, E2E frameworks, or composed by a different number of test scripts).
Self-supervised zero-shot dehazing network based on dark channel prior
Authors: Xiao Xinjie , Ren Yuanhong , Li Zhiwei , Zhang Nannan , Zhou Wuneng 
Published: April 2023

AbstractMost learning-based methods previously used in image dehazing employ a supervised learning strategy, which is time-consuming and requires a large-scale dataset. However, large-scale datasets are difficult to obtain. Here, we propose a self-supervised zero-shot dehazing network (SZDNet) based on dark channel prior, which uses a hazy image generated from the output dehazed image as a pseudo-label to supervise the optimization process of the network. Additionally, we use a novel multichannel quad-tree algorithm to estimate atmospheric light values, which is more accurate than previous methods. Furthermore, the sum of the cosine distance and the mean squared error between the pseudo-label and the input image is applied as a loss function to enhance the quality of the dehazed image. The most significant advantage of the SZDNet is that it does not require a large dataset for training before performing the dehazing task. Extensive testing shows promising performances of the proposed method in both qualitative and quantitative evaluations when compared with state-of-the-art methods.
Graphical Abstract
Study of the Frequency and Specificity of Red Cell Antibodies in Patients with Hemoglobinopathies
Authors: Wilson Manal M. , El Masry Manal M. W. , El-Ghamrawy Mona Kamal , El-Hadi Nessma Abd , Abou-Elalla Amany A. 
Published: April 2023

AbstractPatients with thalassemia and sickle cell disease (SCD) require blood transfusions as part of their supportive care. However, one of the most serious side effects of this treatment is the risk of red cell alloimmunization. The goal of this study was to assess the prevalence and Specificity of red cell alloimmunization in Egyptian thalassemia and sickle cell anaemia patients. This study included 200 multi transfused Egyptian patients, one hundred and forty patients with transfusion dependent thalassaemia and sixty patients with sickle cell anaemia, who were attending the Paediatric Children Hospital-Cairo University at the period from March 2019 to October 2019. Alloantibody identification was made by Diamed- ID microtyping system. In the studied groups both thalassemia and sickle patients, the prevalence of alloimmunization was 22/200 (11%) patients. The two most often alloantibodies were, antibodies against Kell antigen (37%) and against E antigen (30%). The prevalence of alloimmunization was more in females in comparison to males, but it did not reach statistical significance and patients with thalassemia major had higher alloimmunization rates than other studied groups but was not statistically significant. In the D negative patients in the research group, alloimmunization demonstrated a statistically significant difference (p = 0.01). Age, gender, age of transfusion onset and splenectomy were not contributing factors to the antibody presence in the group of patients being investigated. Before receiving blood transfusions, extended red blood cell phenotyping should be thought of as a crucial procedure for hemoglobinopathies patients who would likely have several transfusions. It is advised that haemoglobinopathies patients in Egypt be checked through phenotyping of RBC units for Kell and all Rh antigens to be phenotyped before starting transfusion in these patients which is also standard of care for these patients presently.
Moving forward better marketing for a better world: a path for new research opportunities
Authors: Rashkova Yanina , Moi Ludovica 
Published: April 2023

AbstractThe topic of marketing as a source of a “better world” is gaining rising importance in academia and practice. It represents an opportunity to move towards the development of a more prosperous, fair, and equitable society. Nevertheless, questions remain about how organizations could comprehensively form and nurture marketing for good. In this paper, we display a critical review of the most widely accepted theoretical approaches related to better marketing for a better world (BMBW) to seek new research perspectives. We contribute to extending prior literature by presenting its main criticalities, articulating them around three clusters of shortcomings in view of how recent literature is evolving. Based on this analysis, we then recommend avenues for future research and associated research questions to stimulate and advance further scholarly investigations.
Simulation of pyroshock environment and effect rules of shock response spectrum
Authors: Wang W. , Huang K. , Zhao F. 
Published: April 2023

AbstractThe high-frequency and high-amplitude pyroshock environment during the service of the spacecraft will cause damage to the equipment. Here, we develop a shock test device based on air cannon to simulate the above pyroshock environment. Then, a finite element model was established by explicit dynamic software ANSYS/LS-DYNA, and the simulation results were proved to be consistent with the test data. Based on the theory of Shock Response Spectrum (SRS), the effects of device parameters such as pressure, bullet material and resonant plate material on SRS were investigated via numerical simulation and shock test. This study shows that the amplitude of SRS increases with the increase of pressure in the range of 0.15–0.60 MPa, and the break frequency amplitude has a square root function relationship with the pressure. Additionally, the high-frequency amplitude of SRS was affected by the energy transfer efficiency of the bullet.
Mass Immunizations: A Pocket Guide
Authors: Rice Kathleen , Backer Howard , McFadden Honda , Bode Jessica , Metzner Mitch , Noste Erin , Devereaux Asha V. 
Published: April 2023

Abstract
Numerous state, national, and global resources exist for planning and executing mass vaccination campaigns. However, they are disparate and can be complex. The COVID-19 pandemic highlighted the need for clear, easy to use mass vaccination resources. Meanwhile, annual influenza vaccination, as well as outbreaks such as mpox, demonstrates the need for continued emphasis on timely and effective vaccinations to mitigate outbreaks. This pocket guide seeks to combine relevant resources and basic steps for setting up a mass vaccination clinic, utilizing experience from COVID-19 mass vaccination sites.
What is transformative law?
Authors: Kjaer Poul F. 
Published: April 2023

AbstractIn the western context, law has two functions. It upholds normative expectations and it transforms social phenomena. The latter is expressed through the form-giving function of law, as law designates particular social phenomena, such as, for example, economic, political or religious. Inside such overarching categories, further subcategories can moreover be observed. In relation to economic processes, the legal institutions of competition, contract, corporation and property are, for example, classical examples of the form-giving function of law. The dual function of law is briefly illustrated through a genealogy of imaginaries of law distinguishing between four historically dominant types of law: ‘Law as purpose’; ‘law as a tool’; ‘law as an obstacle’; and ‘law as reflexivity-initiation’. On this background, ten core dimensions of what might become a new episteme of transformative law are fleshed out with the aim of answering the question to what extent it can act as an alternative to the previous four types of law.
Association between low-carbohydrate diet score and incidence of type 2 diabetes among Japanese adults: the JACC Study
Authors: Yaegashi Akinori , Kimura Takashi , Hirata Takumi , Iso Hiroyasu , Tamakoshi Akiko 
Published: April 2023

Abstract
We prospectively examined the association between low-carbohydrate diet (LCD) score and incidence of type 2 diabetes (T2D) in Japanese adults using Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) data. A total of 19 084 (7052 men and 12 032 women) Japanese non-diabetic participants aged 40–79 years, who enrolled in the JACC study between 1988 and 1990, were included in our analysis. Dietary intake was evaluated using a validated food-frequency questionnaire. The overall, animal and vegetable LCD scores were calculated by dividing the study participants into eleven categories based on the percentages of energy from carbohydrates, protein and fat. The incidence of T2D was assessed using a self-administered questionnaire. We used multivariable logistic regression analysis to estimate the odds ratios (ORs) and 95 % confidence intervals (CIs) of incident T2D across the quintile of each LCD score, with adjustment for potential confounders. During the 5-year study period, 490 adults (247 men and 243 women) developed T2D. The multivariable-adjusted OR of incident T2D for the highest v. lowest quintiles of overall and animal LCD scores, respectively, were 0·64 (95 % CI 0·42, 0·99) and 0·83 (95 % CI 0·55, 1·27) for men, 0·78 (95 % CI 0·51, 1·18) and 0·84 (95 % CI 0·57, 1·24) for women. The vegetable LCD score was associated with a lower risk of T2D in men (OR 0·51; 95 % CI 0·33, 0·77). Our results suggest that diets lower in carbohydrates and higher in fat and protein are unlikely to higher the T2D risk among Japanese individuals.
PHOTIUS, ΑΝΑΛΦΑΒHΤΟΣ AND ATTICIST LEXICA
Authors: Tribulato Olga 
Published: April 2023

AbstractPhotius’ lexicon contains an entry on the rare adjectiveἀναλφάβητος(‘illiterate, ignorant’) that cites Phrynichus Atticista. Based on this testimony, the whole passage has been edited as fr. 19 of Phrynichus’Praeparatio sophistica. This article demonstrates that in this lemma Photius conflates material which comes from Phrynichus and one other source, hypothetically identified with the anonymousAntiatticistlexicon, which preserves an abridged entry onἀναλφάβητοςand which Photius employed in the compilation of his lexicon. The article also explores the possibility that the work in which Phrynichus dealt withἀναλφάβητοςwas not thePraeparatio sophisticabut theEclogue.This hypothesis requires challenging some assumptions concerning the transmission of Atticist lexicography in the Byzantine era, chiefly the assumption that material from theEcloguedid not circulate at Byzantium before the fourteenth century.
A PLATONIC ARGUMENT FOR THE IMMORTALITY OF THE SOUL IN CICERO (TVSCVLANAE DISPVTATIONES 1.39–49)
Authors: Watton Matthew 
Published: April 2023

AbstractAn argument in Cicero's Tusculan Disputations (Tusc. 1.39–49) defends psychic immortality by reference to the physical constitution of the soul. This article argues that this ‘Physical Argument’ should be interpreted as a reception of Plato's doctrine of the soul within the philosophical paradigm of the Hellenistic era. After analysing the argument, it is shown that Cicero's proof recasts elements of Plato's Phaedo, in particular the kinship between the soul and the heavens and the soul's essentially contemplative nature, within a corporealist cosmology. The article also argues that Cicero formulates his argument to oppose the Stoic view that the soul's survival after death is only temporary. The Physical Argument emerges as a modernization of Platonic thought, putting Plato into dialogue with contemporary Hellenistic philosophy. Cicero, too, emerges as a more adept philosophical author than is often supposed.
Amidst nets and typhoons: conservation implications of bat–farmer conflicts on Okinawa Island
Authors: Charerntantanakul Weerach , Shibata Shozo , Vincenot Christian Ernest 
Published: April 2023

AbstractFlying foxes are keystone species on islands and are threatened worldwide, particularly by forest degradation, hunting and culling. They are often persecuted if they are perceived as agricultural pests, but the extent of crop damage from flying foxes and the factors triggering their visits to crops are not well established. This study aimed to investigate wildlife-caused damage to tankan oranges Citrus tankan on Okinawa Island, Japan, and interactions between the Ryukyu flying fox Pteropus dasymallus and farmers. We compiled data from three sources: official records of wildlife-caused crop damage, questionnaire surveys of 43 farmers and time-lapse camera surveys conducted at 14 locations during January–February 2018. Official records and the questionnaire survey indicated that the large-billed crow Corvus macrorhynchos caused most damage in a typical year (53–56% of the total damage), followed by P. dasymallus (18–28%). However, time-lapse camera surveys suggested negligible damage caused by P. dasymallus (2.1%) in 2018, a typhoon-free year. Farmers perceived a decline in local population size and stated that at least 2,000 P. dasymallus individuals had died in their orchards during 2008–2018. If this is extrapolated to the whole region, fatalities could have reached 6,500–8,500 individuals during that period. Binomial regression performed on official records demonstrated that damage by P. dasymallus was largely explained by interannual cyclonic activity. Prevalent netting practices could be a serious threat to P. dasymallus: 81% of interviewees reported that flying foxes die from entanglement in their nets. Nevertheless, half of these farmers were satisfied with current crop protection measures. These findings call for prompt remediation with particular focus on implementing more bat-friendly crop protection following strong typhoon seasons.
The relationship between sex and functional outcome in first-episode schizophrenia: the role of premorbid adjustment and insight
Authors: Ventura Joseph , Subotnik Kenneth L. , Han Sam , Hellemann Gerhard S. , Green Michael F. , Nuechterlein Keith H. 
Published: April 2023

AbstractBackgroundStudies that examined sex differences in first-episode patients consistently show that males compared to females have poor premorbid adjustment, earlier age of onset, worse clinical characteristics, and poorer outcomes. However, little is known about potential mediators that could explain these sex differences.MethodsOur sample consisted of 137 individuals with first episode schizophrenia (males, n = 105; 77%) with a mean age of 22.1(s.d. = 4.1) years and mean education of 12.5(s.d. = 1.7) years. At entry, patients were within 2 years of their first psychotic episode onset. Baseline assessments were conducted for premorbid adjustment, symptoms, cognitive functioning, insight, and at 6-months for role and social functioning.ResultsMales as compared to females had poorer premorbid adjustment across several key developmental periods (p < 0.01), an earlier age of onset [M = 20.3(3.3) v. 22.8(5.6), p = 0.002], more negative symptoms (p = 0.044), poorer insight (p = 0.031), and poorer baseline and 6-month role (p = 0.002) and social functioning (p = 0.034). Several of these variables in which males showed impairment were significant predictors of 6-month role and social functioning. Premorbid adjustment and insight mediated the relationship between sex and role and social functioning at 6-months, but not negative symptoms.DiscussionMales compared to females were at lower levels across several key premorbid and clinical domains which are strongly associated with functional outcome supporting the hypothesis that males might have a more disabling form of schizophrenia. The relationship between sex with role and social functioning was mediated through premorbid adjustment and insight suggesting pathways for understanding why females might have a less disabling form of schizophrenia.
An intuitionistic set-theoretical model of fully dependent CC
Authors: Sato Masahiro , Garrigue Jacques 
Published: April 2023

AbstractWerner’s set-theoretical model is one of the simplest models of CIC. It combines a functional view of predicative universes with a collapsed view of the impredicative sort “
${\tt Prop}$
”. However, this model of
${\tt Prop}$
is so coarse that the principle of excluded middle
$P \lor \neg P$
holds. Following our previous work, we interpret
${\tt Prop}$
into a topological space (a special case of Heyting algebra) to make the model more intuitionistic without sacrificing simplicity. We improve on that work by providing a full interpretation of dependent product types, using Alexandroff spaces. We also extend our approach to inductive types by adding support for
${\mathsf{list}}$
s.
Pre-Glenn aorto-pulmonary collaterals in single-ventricle patients
Authors: Sharma Varun J. , Carlson Laura , Esch Jesse , Gopal Mallika , Gauvreau Kimberlee , Wamala Isaac , Muter Angelika , Porras Diego , Nathan Meena 
Published: April 2023

AbstractBackground:In single-ventricle patients undergoing staged-bidirectional Glenn, 36–59% have aorto-pulmonary collateral flow, but risk factors and clinical outcomes are unknown. We hypothesise that shunt type and catheter haemodynamics may predict pre-bidirectional Glenn aorto-pulmonary collateral burden, which may predict death/transplantation, pulmonary artery or aorto-pulmonary collateral intervention.Methods:Retrospective cohort study of patients undergoing a Norwood procedure for single-ventricle anatomy. Covariates included clinical and haemodynamic characteristics up to/including pre-bidirectional Glenn catheterisation and aorto-pulmonary collateral burden at pre-bidirectional Glenn catheterisation. Multivariable models used to evaluate relationships between risk factors and outcomes.Results:From January 2011 to March 2016, 104 patients underwent Norwood intervention. Male sex (odds ratio 3.36, 95% confidence interval 1.17–11.4), age at pre-bidirectional Glenn assessment (2.12, 1.33–3.39 per month), and pulmonary to systemic flow ratio (1.23, 1.08–1.41 per 0.1 unit) were associated with aorto-pulmonary collateral burden. Aorto-pulmonary collateral burden was not associated with death/transplantation (hazard ratio 1.19, 95% confidence interval 0.37–3.85), pulmonary artery (sub-hazard ratio 1.38, 0.32–2.61), or aorto-pulmonary collateral interventions (sub-hazard ratio 1.11, 0.21–5.76). Longer post-Norwood length of stay was associated with greater risk of death/transplantation (hazard ratio 1.22 per week, 95% confidence interval 1.08–1.38), but lower risk of aorto-pulmonary collateral intervention (sub-hazard ratio 0.86 per week, 95% confidence interval 0.75–0.98). Time to pre-bidirectional Glenn catheterisation was associated with lower risk of pulmonary artery (sub-hazard ratio 0.80 per month, 95% confidence interval 0.65–0.98) and aorto-pulmonary collateral intervention (sub-hazard ratio 0.79, 0.63–0.99). Probability of moderate/severe aorto-pulmonary collateral burden increased with left-to-right shunt (22.5% at <1.0, 57.6% at >1.4) and the age at pre-bidirectional Glenn catheterisation (10.6% at <2 months, 56.9% at >5 months).Conclusions:Aorto-pulmonary collateral burden is common after Norwood procedure and increases as age at bidirectional Glenn increases. As expected, higher pulmonary to systemic flow ratio is a marker for greater aorto-pulmonary collateral burden pre-bi-directional Glenn; aorto-pulmonary collateral burden does not confer risk of death/transplantation or pulmonary artery intervention.
Analyzing Demographic Variabilities Associated With Age of Diagnosis of Schizophrenia Among Patients in Controlled Clinical Trials
Authors: Singh Vijay , Alnsour Mahmoud , Gopal Nikhil , Shin Amber , Kulkarni Shreedhar , Uga Aghaegbulam 
Published: April 2023

AbstractBackgroundPrior literature and epidemiological data suggests that the age of diagnosis of schizophrenia (AOD) follows a bimodal and trimodal distribution for males and females, respectively. The studies used to generate these findings were often small and relied on self-reported patient data from a single geographic region in addition to other methodological limitations. We replicated these studies using a modern big data approach by combining raw data from large randomized controlled clinical trials.MethodsPatient-level data from 15 similarly designed, randomized, double-blind, placebo-controlled, crossover studies with patients using paliperidone extended-release tablets, paliperidone palmitate 1-month, and paliperidone palmitate 3-month, were obtained through the Yale Open Data Access Initiative (YODA). Descriptive statistics and histograms were calculated for continuous variables. A multivariable linear regression was performed with AOD as the outcome variable. Race and sex were used as predictor variables.ResultsOur final analysis included 7881 patients consisting of male (n=4962) and female (n=2919) patients among different racial demographics. Race was consolidated into the following groups: Asian (n=949), Black (n=1692), Hispanic (n=3), Southeast Asian (n=17), White (n=4769), and other (n=343) based on patient self-identification on the YODA datasets. A chi-square test revealed that there is a statistically significant association between patient sex and AOD (x2=295.61, df=68, p < 0.0001). By proxy, this likely means that sex affects age of onset (AOS) as well. Our linear regression output with sex as a predictor of AOD revealed that only the male variable was found to have a statistically significant relationship (p<0.0001) with AOD and resulted in a lower AOD. Histograms generated with the frequency of occurrences against AOD for both male and female patients appeared to be unimodally distributed and skewed right. However, the AOD for female and male patients were found to be 28.79 and 25.44 years old, respectively. This demonstrates that while both male and female AOD are distributed unimodally, there are slight differences in their distributions.ConclusionOur analysis differs from previous studies and finds that AOD for male and female patients are seen in a unimodal distribution as compared to previous literature that shows a bimodal and trimodal distribution. Our findings not only call for a re-evaluation of previous epidemiological understandings of AOD but may support future efforts in understanding the origins and typical clinical presentations of patients with newly developed symptomatology of schizophrenia as well as support clinicians’ perspectives as part of clarifying differential diagnoses. Further studies can also continue to evaluate possible correlations among different races.FundingNo Funding