bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do slow slip earthquakes inhibit catastrophes? Geologic evidence from the Guerrero segment, Mexican subduction zone
Authors: Ramírez-Herrera María-Teresa , Cerny Jan , Corona Nestor , Gaidzik Krzysztof , Sugawara Daisuke , Forman Steven L. , Machain-Castillo M. Luisa , Gogichaishvili Avto 
Published: May 2023

Abstract

Globally, the largest tsunamigenic earthquakes have occurred along subduction zones. The Mw>9 devasting events in Chile, Sumatra, and Japan struck in areas where no instrumental records reported similar events. The one-thousand kilometer-long Mexican subduction zone (MSZ), where the Rivera-Cocos plates subduct under the North American plate, has no records of events of such magnitude. Historical and geologic evidence suggests the occurrence of a Mw8.6 tsunamigenic earthquake in the MSZ. However, the Guerrero segment (GS) has not experienced a large event in over 100 years. Several hypotheses have been proposed to explain this, e.g., slow slip events (SSEs) and the rheology of this segment favoring slow slip over rapid slip. However, none of these hypotheses have been confirmed with evidence. Here, we show geologic evidence that reveals a ca. 2000-year history of large tsunamigenic earthquakes and demonstrate that a Mw>8 event occurred ca. AD 1300 in this segment of the MSZ, indicating a long and variable earthquake recurrence (> 700 years). This evidence prompts the assessment of earthquake and tsunami potential using long-term evidence combined with instrumental observations along the MSZ and other subduction zones.
Development of an approach to the creation of an intellectual system of national security management
Authors: Shyshatskyi Andrii , Sova Oleg , Zhuravskyi Yurii , Zaitsev Mykola , Andriishena Halyna 
Published: May 2023

The object of the research is intelligent systems for collecting, processing and analyzing information about the state of national security.
Investigated problem: The problem that is solved in the research is the problem of building intelligent systems for collecting, processing and analyzing information about the state of national security with limitations on the available computing resources, reliability and given speed of processing of various types of data circulating in it. The main scientific results obtained during the study by the authors are:
proposed approach to the development of intelligent systems for the collection, processing and analysis of information on the state of the state's national security. The proposed approach takes into account the security of the system, available forces and means, purpose, system effect, method of formation, resource composition, structure, management, the process of functioning according to the purpose, resource consumption and the specified efficiency criterion. This will allow to justify the requirements for software and hardware of intelligent systems for collecting, processing and analyzing information about the state of the state's national security.
proposed architecture of intelligent systems for collecting, processing and analyzing information about the state of national security of the state. Its approximate composition, functional purpose and structure of the database management system are substantiated.
The area of practical use of the research results: It is advisable to use the proposed scientific results when conducting research and development works on the creation of intelligent systems for collecting, processing and analyzing information about the state of national security of the state, and developing requirements for hardware and software of this type of systems.
Field of application: software, information systems, decision support systems.
Yuchuanite-(Y), Y2(CO3)3·H2O, a new hydrous yttrium carbonate mineral from the Yushui Cu deposit, South China
Authors: Yao Wei , Liu Peng , Li Guowu , Sun Ningyue , Yang Wenqiang , Jiang Chengyao , Du Wei , Zhang Chao , Song Wenlei , Cook Nigel J. , Mao Jingwen 
Published: May 2023

Abstract
A new mineral species, yuchuanite-(Y), ideally Y2(CO3)3·H2O, has been discovered and characterized in the Yushui Cu deposit in South China. The mineral occurs in bedded/massive ore and is associated with bornite, chalcopyrite, galena, sphalerite, bastnäsite-(Y), xenotime-(Y), anhydrite, and quartz. Individual crystals range in size from 30 to 300 μm. No twinning is observed. The mineral is colorless and transparent with a vitreous luster. The calculated density is 3.62 g/cm3. An electron microprobe analysis yields the empirical formula (based on 10 O apfu), (Y1.61Yb0.11Er0.11Dy0.08Ho0.03 Gd0.02Tm0.02)Σ1.99(CO3)3·H2O.
Yuchuanite-(Y) is triclinic, with space group P1 (#2), Z = 6, and unit-cell parameters a = 6.2134(3) Å, b = 8.9697(3) Å, c = 19.9045(7) Å, α = 91.062(3)°, β = 90.398(3)°, γ = 91.832(3)°, and V = 1108.54(8) Å3. The structure is constructed from (110) sheets of eight-coordinated Y polyhedra and C trigonal planar groups. All Y polyhedra are linked by shared edges. The Y atoms occupy six independent crystallographic sites of two different coordination types: [YO7(H2O)] and [YO8].
The chemical composition of yuchuanite-(Y) is similar to tengerite-(Y), Y2(CO3)3·2–3H2O, but is distinct in the crystal structure, such as crystal system, space group, and unit cell, from that of tengerite-(Y). The Y polyhedra of tengerite-(Y) are nine-coordinated, while those of yuchuanite-(Y) are eight-coordinated. Moreover, their structures could be both described as sheet structures built up from Y polyhedra and CO3 trigonal planar groups but link together in significantly different ways. Thus, yuchuanite-(Y) is not a polytype of tengerite-(Y) but is an independent mineral species.
Domestic Credit and Stock Market Impact on Economic Growth: A New Evidence in Five ASEAN Countries
Authors: Asmarani Tuti Eka , Ningsih Endah Ayu 
Published: May 2023

Capital accumulation and technological innovation had been the two channels through which the financial sector plays a vital role in the growth of economy. However, there are some different results between banking and stock market. The research tested the Solow-Swan growth model augmented with financial markets to show that domestic credit markets and equity from stock markets are two long run determinants of Gross Domestic Products (GDP) per capita in five ASEAN countries: Indonesia, Malaysia, Singapore, Thailand, and Philippines. The research used data from 2000 to 2019 tested with panel regression. The result shows that all determinant variables have a positive impact on economic growth. The domestic credit also has a higher impact on the growth of economy than the stock market. In addition, domestic credit and stock market has statistically significant positif impact to economic growth across five ASEAN countries. The researchalso finds that although population in five ASEAN countries give positive effect to economic growth, it is statistically not convincing. It is suggested that people in ASEAN have already used technology, so population augmented encourages economic growth.
Securing drinking water supply in smart cities: an early warning system based on online sensor network and machine learning
Authors: Lu Haiyan , Ding Ao , Zheng Yi , Jiang Jiping , Zhang Jingjie , Zhang Zhidong , Xu Peng , Zhao Xue , Quan Feng , Gao Chuanzi , Jiang Shijie , Xiong Rui , Men Yunlei , Shi Liangsheng 
Published: May 2023

AbstractTo enhance the quality of life and ensure sustainability in crowded cities, safe management of drinking water using cutting-edge technologies is a priority. This study developed an intelligent early warning system (EWS) for alarming and controlling risks from bacteria and disinfection byproducts in a drinking water distribution system (DWDS), named BARCS (Bacterial Risk Controlling System). BARCS adopts an artificial intelligence (AI) approach to data-driven prediction and considers total chlorine (TCl) concentration as the pivot indicator for risk identification and control. First, the machine learning-based AI model in BARCS can provide a reliable prediction of TCl concentration in a DWDS, with an average R2 of 0.64 for the validation set, while offering great flexibility for BARCS to adapt to various conditions. Second, TCl concentration was proven to be a good indicator of bacterial risk in a DWDS, as well as a cost-effective surrogate variable to assess disinfection byproduct risk. Third, the robustness analysis demonstrates that with state-of-the-art water quality monitoring technologies, online implementation of BARCS in real-world settings is feasible. Overall, BARCS represents a promising solution to the safe management of drinking water in future smart cities.
Role of Fibrinogen in Type-2 Diabetes Mellitus with Diabetic Neuropathy
and its Preliminary Mechanism
Authors: Wei Li , Gu Wei-Li , Li Zhen-Hong , Zhang Si-Qin , Ao Pian , Zhu Xiao-Bei , Zhao Xin , Zhang Xin-Yue , Zhang Deng-Feng , Huang Xiao-Juan , Jiang Yu 
Published: May 2023

Introduction:
Diabetic peripheral neuropathy (DN) is the most common complication of
type 2 diabetes mellitus (T2DM).

Objective:
This study aimed to explore the role of fibrinogen (FIB) in T2DM neuropathy and its
preliminary mechanism.

Methods:
Ten male Sprague-Dawley rats were divided into a normal control group (NC group) and a
T2DM neuropathy model group (DN group). The DN group was given a high-energy diet and
streptozotocin, while the NC group was given a normal diet and a citric acid buffer. The expression
levels of related proteins were analysed.

Results:
Electrophysiology: Compared with the NC group, the conduction latency of the
somatosensory-evoked potential and nerve conduction velocity was prolonged in the DN group, while
the motor nerve action potential was decreased. As seen under a light microscope, the peripheral
nerve fibres in the DN group were swollen, and the nerve fibres in the posterior funiculus of the
spinal cord were loose or missing. Moreover, as seen under an electron microscope, the peripheral
nerve demyelination of the DN group was severe, with microvascular blood coagulation, luminal
stenosis, and collapse. Compared with the NC group, in the DN group, the expression of FIB was
positively correlated with the expression of both ionised calcium-binding adaptor molecule-1 and
glial fibrillary acidic protein. Compared with the NC group, in the DN group, the expression of
platelet/endothelial cell adhesion molecule-1 and B-cell lymphoma 2 was negatively correlated.

Conclusion:
The increased concentration of FIB may be the cause of neuropathy, and its mechanism
may be related to its promotion of inflammatory response, blood coagulation, and vascular stenosis.
Attack Site Density of a Highly-efficient PET Hydrolases
Authors: Li Qiang , Liu Wenhong , Jing Nannan , Li Qingqing , Yang Kang , Wang Xia , Yao Jianzhuang 
Published: May 2023

Introduction:
Poly (ethylene terephthalate) (PET) is one of the most abundant polyester
materials used in daily life and it is also one of the main culprits of environmental pollution. ICCG
(F243I/D238C/S283C/Y127G) is an enzyme that performs four modifications on the leaf branch
compost keratase (LCC). It shows excellent performance in the hydrolysis of PET and has a great
potential in further applications.

Methods:
Here, we used ICCG to degrade PET particles of various sizes and use the density of attack
sites (Γattack) and kinetic parameters to evaluate the effect of particle size on enzyme degradation
efficiency. We are surprised to observe that there is a certain relationship between Km and Γattack. In
order to further confirm the relationship, we obtained three different enzymes (Y95K, M166S and
H218S) by site-directed mutagenesis on the basis of ICCG.

Result:
The results confirmed that there was a negative correlation between Km and Γattack. In
addition, we also found that increasing the affinity between the enzyme and the substrate does not
necessarily lead to the increase of degradation rate.

Conclusion:
These findings show that the granulation of PET and the selection of appropriate
particle size are helpful to improve its industrial application value. At the same time, additional
protein engineering to increase ICCG performance is realistic, but it can’t be limited to enhance the
affinity between enzyme and substrate.
Blood-based microRNAs as Potential Diagnostic Biomarkers for
Melanoma: A Meta-Analysis
Authors: Aalami AmirHossein , Abdeahad Hossein , Mokhtari Ali , Aalami Farnoosh , Amirabadi Amir , Aliabadi Ehsan Kargar , Pirzade Omid , Sahebkar Amirhossein 
Published: May 2023

Introduction:
Circulating microRNAs (miRNAs) serve as noninvasive diagnostic
markers in many cancers. This meta-analysis aims to evaluate the diagnostic efficacy of circulating
microRNAs for melanoma.

Material and Methods:
The pooled sensitivity, specificity, positive likelihood ratio, negative
likelihood ratio, diagnostic odds ratio, and ROC curve were evaluated using the Meta-Disc
V.1.4 and Comprehensive Meta-Analysis V.3.3 software packages. To investigate the heterogeneity,
the I2 and Chi-square tests were used. The publishing bias was evaluated using Begg’s
rank correlation and Egger regression asymmetry tests.

Results:
A total of 9 articles covering 13 studies (more than 50 miRs individually and in combination)
were included, containing 1,355 participants (878 cases and 477 controls). The overall
pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic
odds ratio (DOR), and AUC were 0.78 (95% CI: 0.76-0.81), 0.80 (95% CI: 0.77-0.83),
4.32 (95% CI: 3.21-5.82), 0.17 (95% CI: 0.09-0.32), 28.0 (95% CI: 15.34-51.09), and 0.91, respectively.
According to Begg's and Egger's tests, there was no publication bias (Begg's p =
0.160 and Egger's p = 0.289).

Conclusion:
Circulating miRNAs can serve as fair and non-invasive diagnostic biomarkers
for melanoma. Additionally, specific miRNAs still need to be discovered for diagnosing melanoma.
Different Types of Naturally based Drug Delivery Carriers: An Explanation
and Expression of Some Anti-cancer Effects
Authors: Masoomzadeh Salar , Gholikhani Tooba , Barfar Ashkan , Asnaashari Solmaz , Javadzadeh Yousef 
Published: May 2023

Abstract:
Cancer remains one of the leading causes of death worldwide and a major impediment to increasing
life expectancy. However, survival rates with average standard cancer treatment strategies have not significantly
improved in recent decades, with tumor metastasis, adverse drug reactions, and drug resistance still posing
major challenges. Replacement therapies are essential for treating this terrible disease. Recently, there has been
a dramatic increase in the use of phytochemical-derived conjugated chemotherapeutic agents due to their biocompatibility,
low cytotoxicity, low resistance, and dynamic physiochemical properties that distinguish normal
cells in treating various types of cancer. The use of plant-based carriers has many advantages, such as the availability
of raw materials, lower cost, lower toxicity in most cases, and greater compatibility with the body's structure
compared to chemical and mineral types of carriers. Unfortunately, several challenges complicate the efficient
administration of herbal medicines, including physicochemical disadvantages such as poor solubility and
instability, and pharmacokinetic challenges such as poor absorption and low bioavailability that can cause
problems in clinical trials. Novel delivery systems such as liposomes, phytosomes, nanoparticles, and nanocapsules
are more suitable as delivery systems for phytomedicinal components compared to conventional systems.
The use of these delivery systems can improve bioavailability, pharmacological activity, prolonged delivery,
and provide physical and chemical stability that increases half-life. This article discusses different types of phytocompounds
used in cancer treatment.
Age-Related Macular Degeneration - Therapies and Their Delivery
Authors: Ponnusamy Chandrasekar , Ayarivan Puratchikody , Selvamuthu Preethi , Natesan Subramanian 
Published: May 2023

Abstract:
Age-related macular degeneration (ARMD) is a degenerative ocular disease that is the most
important cause of irreversible vision loss in old-aged people in developed countries. Around fifty percent
of vision impairments in developed countries are due to ARMD. It is a multifaceted disease that is
associated with both genetic and environmental risk factors. The most important treatments option for
ARMD includes laser photocoagulation, photodynamic therapy (PDT), Anti-VEGF Injections, and
combination therapies. In this review, we also propose that topical ocular drug delivery with nanocarriers
has more attention for the treatment of ARMD. The nanocarriers were specially designed for enhanced
corneal residential time, prolonged drug release and action, and minimizing the frequency of
administrations. Different types of nanocarriers were developed for the topical ocular delivery system,
such as nanomicelles, nanoemulsions, nanosuspensions, liposomes, and polymeric nanoparticles. These
topical ocular nanocarriers were administered topically, and they can fix the hydrophobic substances,
increase solubility and improve the bioavailability of an administered drug. Hence the topical ocular
delivery systems with nanocarriers provide a safe and effective therapeutic strategy and promising tool
for the treatment of posterior segment ocular diseases ARMD.
Medicinal Plants and Bioactive Compounds with Potential Anti-inflammatory and Antidiabetic Activities: A Review
Authors: Bouknana Saliha , Rherabi Amal El , Abdnim Rhizlan , Berraaouan Ali , Bnouham Mohamed 
Published: May 2023

Background:
Inflammation is a complex process. Persistent and uncontrolled inflammation
may act as an etiologic factor for many chronic disorders like diabetes.

Objective:
This review aims to classify the anti-inflammatory and antidiabetic medicinal plants, their
traditional uses, and their active compounds that have been tested for their anti-inflammatory and antidiabetic
effects.

Methods:
We checked scientific publications in various electronic databases from 1981 to 2021. All the
molecular structures were provided in ADC/ChemSketch.

Results:
We reviewed 58 species, belonging to 39 families. These species have long been used in traditional
medicine to cure a variety of ailments, including, dysentery, typhoid fever, anemia, digestive and
cardiac disorders, as well as diabetes and inflammation. Asteraceae represents the dominant family. The
most potent anti-inflammatory and antidiabetic active compounds were reviewed including myricetin,
quercetin, hesperetin, rutin, luteolin, chlorogenic acid, vanillic acid, gallic acid, ferulic acid, benzoic acid,
cinnamic acid, gentisic acid, camphor, 1,8-cineol, p-cymene, limonene, linalool, thymoquinone, carvacrol,
aromadendrine, α-pinene, lycopene, phytol, imperatorin, chalepin, hexadecanoic acid, linoleic
acid, tellimagrandin I, and trigalloyl glucose.

Conclusion:
This review indicates that medicinal plants have many therapeutic dynamics against inflammation
and diabetes that could be exploited for the discovery of therapeutic preparation or agent for treating
the two illnesses at the same time.
E. hirae Causing Biliary Tract Infection in a Patient with
Cholangiocarcinoma: A Case Report
Authors: Sharad Neha , Srivastava Smriti , Ningombam Aparna , Malhotra Rajesh , Mathur Purva 
Published: May 2023

Introduction:
E. faecium and E. faecalis are the common species of Enterococcus responsible
for the majority of infections. Earlier, species other than the common ones were usually unidentified
and reported as Enterococcus species. However, modern equipment, like MALDI-TOF and
VITEK2, have been utilitarian, helping us to identify the previously unidentified species. E. hirae is an
organism seldom reported to cause human infections. Here, we report a case of a biliary tract infection
in a female patient with cholangiocarcinoma caused by E. hirae.

Case:
A 56-year-old female presented with fever and abdominal pain. Bile aspirated during the ERCP
was received in our laboratory. The gram stain of the bile sample revealed abundant polymorphonuclear
leucocytes along with gram-positive diplococci. The organism failed to grow on MacConkey agar.
On blood agar, non-hemolytic colonies grew. The organism was identified as E. hirae by MALDI-TOF
MS. The antibiotic susceptibility performed using VITEK2 revealed it to be resistant to high-level
gentamicin and susceptible to all remaining drugs. She was successfully treated with oral ciprofloxacin
for the infection.

Discussion:
Bile is colonized with bacteria due to obstruction in the biliary tree, leading to cholangitis.
This causes bacterial proliferation and translocation of bacteria into the systemic circulation. Our case
was resistant to high-level gentamicin, while all previously reported cases were susceptible. The resistant
isolates of E. hirae being isolated from cattle and their surroundings amidst the rampant use of
antibiotics in livestock can pose a difficult situation for humans. Thus, there should be regulations on
antibiotic usage in livestock. Cases like these should be reported and recognized for their potential to
cause outbreaks if they remain unreported.

Conclusion:
Thus, E. hirae, when encountered, should not be ignored but considered a pathogen and
reported. The presence of drug-resistant organisms in cattle and their surroundings, their zoonotic potential
to cause infections in humans, and the uncontrolled usage of antibiotics in livestock are causes
for concern. Thus, we need to be more vigilant regarding it in the future.
Untangling Intimate Care Experiences for Patients Admitted to Public Hospitals in South Africa
Authors: Shakwane Simangele 
Published: May 2023

Background:
Hospital admission can be a traumatic and humiliating experience for patients due to the institutionalised attire they must wear. Intimate care may trigger experiences of helplessness and disrespect due to exposure to their body parts and having to be touched by nurses.

Objective:
This research aimed to explore and describe patients’ perceptions of their bodies and their experiences of intimate care execution during their hospital stay.

Methods:
A qualitative explorative-descriptive design and Trauma-informed care framework were used to explore and describe the participants’ perceptions and experiences of intimate care execution during admission to the two sampled hospitals. Twenty participants admitted to medical and surgical units were purposively recruited. Data was collected using semi-structured interviews, and thematic analysis was used to give meaning to the data.

Results:
Three overarching themes emerged from the data: the sacredness of the human body; Patients want their dignity to be respected during intimate care and touch; and creating the nurse-patient intimate care relationship. Patients wish the nurses to maintain their dignity and privacy. Intimate care and touch should be initiated in a safe environment where patients can make informed decisions.

Implications for Nursing:
Declothing of personal attire during admission violates patients’ dignity and privacy and is dehumanising. During intimate care and touch, nurses should create a cultural, religious and gender safe environment, allowing inpatients to make informed decisions regarding the care provided to their bodies.

Conclusion:
Patients’ beliefs system should be incorporated into autonomy and informed decisions about the care to be provided to naked bodies. Hospitalisation should not reinforce physical and psychological trauma. Respect and dignity are paramount when caring for the patient’s body.