bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating Antiaromaticity: Thermally-selective Skeletal Rearrangements at Interfaces
Authors: Pérez-Elvira Elena , Barragán Ana , Chen Qifan , Soler-Polo Diego , Sánchez-Grande Ana Sánchez-Grande , Vicent Diego J. , Lauwaet Koen , Santos José , Mutombo Pingo , Mendieta-Moreno Jesús I. , Torre Bruno De la , Gallego José M. , Miranda Rodolfo , Martin Nazario , Jelinek Pavel , Urgel José , Ecija David 
Published: January 2023

Abstract
Antiaromatic polycyclic conjugated hydrocarbons (PCHs) are attractive research targets in modern organic chemistry in view of their interesting structural, electronic and magnetic properties. Unlike aromatic compounds, the synthesis of antiaromatic PHs is challenging as a result of their high reactivity and lack of stability, stemming from the small energy gap between their highest occupied and lowest unoccupied molecular orbitals. In this work, we describe a strategy toward the introduction of antiaromatic units in PHs viathermally selective intra- and intermolecular ring-rearrangement reactions of dibromomethylene-functionalized molecular precursors upon sublimation on a hot Au(111) metal surface, not available in solution chemistry. The synthetic value of these reactions is proven by 1) the integration of pentalene segments into acene-based precursors which undergo intramolecular ring-rearrangement; 2) the formation of π-conjugated ladder polymers, linked through cyclobutadiene connections, prior to ring-rearrangement and [2+2] cycloaddition reactions of indenofluorene-based precursors. The elucidation of the reaction products of the title reactions are investigated by scanning tunneling and non-contact atomic force microscopy investigations, and the mechanistic insights are unveiled by state-of-the-art computational studies.
Myocardial T1 native mapping and extracellular volume in asymptomatic female carriers of Duchenne muscular dystrophy gene mutations
Authors: Masárová Lucia , Panovsky Roman , Pešl Martin , Pisciotti Mary Luz Mojica , Holeček Tomas , Kincl Vladimír , Juříková Lenka , Machal Jan , Opatřil Lukáš , Feitová Věra 
Published: January 2023

Abstract
Background
Female carriers of dystrophin gene mutations (DMD-FC) were previously considered non-manifesting, but in recent decades, cardiomyopathy associated with muscular dystrophy and myocardial fibrosis has been described. Our study aimed to assess prospectively myocardial fibrosis in asymptomatic DMD-FC compared to a sex- and age-matched control group (CG) using T1 native mapping and extracellular volume (ECV) by cardiovascular magnetic resonance (CMR) imaging. To our knowledge, this approach has not been published yet.
Material and methods
38 DMD-FC (mean age 39.1 ± 8.8 years) and 22 CG (mean age 39.9 ± 12.6 years) were included. Using CMR, T1 native relaxation time and ECV were determined in each group. Late gadolinium enhancement (LGE) was assessed in all cases.
Results
T1 native relaxation time was similar for DMD-FC and CG (1005.1 ± 26.3 ms vs 1003.5 ± 25.0 ms; p-value = 0.81). Likewise, the global ECV was also similar between the groups (27.92 ± 2.02% vs 27.10 ± 2.89%; p-value = 0.20). The segmental analysis of ECV according to the American Heart Association classification did not show any differences between DMD-FC and CG.
Conclusion
There were no statistically significant differences in the global T1 native relaxation time and global or segmental ECV.
Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure
Authors: Carvalho Luana , Chen Hu , Maienschein-Cline Mark , Glover Elizabeth , Pandey Subhash , Lasek Amy 
Published: January 2023

AbstractWe previously discovered using transcriptomics that rats undergoing withdrawal after chronic ethanol exposure had increased expression of several genes involved in RNA splicing in the hippocampus. Here, we examined RNA splicing in the rat hippocampus during withdrawal from chronic ethanol exposure and in postmortem hippocampus of human subjects diagnosed with alcohol use disorder (AUD). We found that expression of the gene encoding the splicing factor, poly r(C) binding protein 1 (PCBP1), was elevated in the hippocampus of rats during withdrawal after chronic ethanol exposure and AUD subjects. We next analyzed the rat RNA-Seq data for differentially expressed (DE) exon junctions. One gene,Hapln2, had increased usage of a novel 3’ splice site in exon 4 during withdrawal. This splice site was conserved in humanHAPLN2and was used more frequently in the hippocampus of AUD compared to control subjects. To establish a functional role for PCBP1 inHAPLN2splicing, we performed RNA immunoprecipitation with a PCBP1 antibody in rat and human hippocampus. PCBP1 association was enriched near theHAPLN2exon 4 3’ splice site in the hippocampus of rats during ethanol withdrawal and AUD subjects. Our results indicate a conserved role for the splicing factor PCBP1 in aberrant splicing ofHAPLN2after chronic ethanol exposure. As theHAPLN2gene encodes an extracellular matrix protein involved in nerve conduction velocity, use of this alternative splice site is predicted to result in loss of protein function that could negatively impact neurotransmission in AUD.
Perception on and the intention to use 5G technology in Malaysian SMEs
Authors: Khee Pek Chuen , Ee Foo Fang , Chinna Karuthan 
Published: January 2023

Abstract
In wireless communication, Fifth Generation (5G) Technology is a recent generation of mobile networks. This technology offers a great deal of advantage to industries. 5G technology can help businesses in enhancing efficiency and promoting innovations. Improved efficiency helps in reducing cost and consequently increasing revenue. Small and medium enterprises (SMEs) are the backbone of a country’s economy. Unlike the large companies, SMEs have not paid much attention to 5G technology. SMEs must be prepared to move into this big digital transformation or lose out in the competitive market. The major concerns of SMEs in deploying 5G technology include lack of expertise, switching cost, reliability, security, environment, and interference with other systems. In this study, we explored the perceptions of Malaysian SME employees on 5G technology. Positive perceptions on 5G features, competitive advantage, improved efficiency, impact of productivity, economic benefit and benefits to customers are high. However, there are high concerns in the deploying of the 5G technology and the Malaysian SMEs seem to have a wait-and-see attitude in implementing the 5G technology.
Stroke Mimics in a Brazilian Stroke Center: a Retrospective Cohort in a Brazilian Stroke Unit
Authors: Santos Júlio César Claudino dos , Ribas Michelle Zonkowski , Fernandes Alexandre Chaves , de Mendonça Lucas Lopes Penido , Filho Paulo Cesar de Santiago , Santiago Ruan Braga , Gomes Gabriel Felipe , Santos Nayla Lima dos , Costa Rafaella Iughetti da , Galvão Stéfani Lara , Filho Luciano Barroso de Albuquerque , Duarte Fairane Sousa , Sallem Camilla Costa , Veras Arthur de Oliveira , Noleto Felipe Micelli , Ramanzini Luis Guilherme , Paticcié Gabriela Ferreira , Nones Diogo Pasquali 
Published: January 2023

Abstract
Background: stroke is a highly common neurologic disease, with great mortality and morbidity rates. It is a cerebrovascular condition characterized by a deficiency in the blood supply that should reach the nervous tissue. It can be classified into two types, depending on its etiology: ischemic and hemorrhagic stroke, the first one being the most common. The correct diagnosis of this condition is a challenge, especially in cases of confusing conditions, such as stroke mimics (SM). A highly detailed epidemiologic description and previous knowledge of the disease can help to recognize it. In cases of stroke, a quick revascularization treatment is necessary for a good clinical outcome, however, the inadvertent administration of thrombolytics to the patient with SM can cause hemorrhage and death, as well as unnecessary costs. The present study consisted in evaluating the patients admitted in the stroke unit of the Clinical Hospital Complex of the Federal University of Paraná in Brazil, between October 2012 and September 2013, and describing the prevalence, clinical presentation, etiology, and treatment outcomes in the SM cases primarily diagnosed as a stroke.
Results: 10 patients (7.1%) of the total number of patients with less than four hours of symptoms onset were considered SM and six were submitted to intravenous thrombolysis. The main clinical presentations were motor symptoms (90%) and dysarthria and sensitive symptoms (60%). Regarding the etiology of the patients with SM, six patients (60%) had functional disorders, one (10%) had Todd paresis, one (10%) exogenous intoxication, one (10%) diabetic ketoacidosis, and one (10%) presented with a clinically isolated syndrome.
Conclusions: our results showed that an important percentage of patients admitted to a stroke unit are SM and that a significant part of these SM is subjected to unnecessary thrombolytic procedures. Thus, further studies are necessary and important to develop well-defined guidelines that stratify the risk of SM and evaluate, based on the stratification, the risk-benefit of soliciting imaging methods that can help to distinguish between stroke and SM.
Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury
Authors: Tao Luyang , Gao Yuan , Wang Tao , Cheng Ying , Wu Yumin , Zhu Luwen , Gu Zhiya , Wu Youzhuang , Cai Luwei , Zhang Yidan , Gao Cheng , Chen Xueshi , Li Lili , Li Jing , Wang Zufeng , Wang Ying , Wang Fudi , Wu Yinmin , Luo Chengliang 
Published: January 2023

Abstract
Although traumatic brain injury (TBI) is a common cause of death and disability worldwide, there is currently a lack of effective therapeutic drugs or targets. To reveal the complex pathophysiologic mechanisms of TBI, we performed transcriptome analysis of the mouse cerebral cortex and immunohistochemical analysis of human cerebral tissues. The genes Mt1, Mt2, Il33, and Fth1 were upregulated post-TBI and enriched in pathways associated with inflammatory response, oxidative phosphorylation, and ferroptosis. As an agonist of MT1/2, melatonin (MLT) has anti-oxidative stress, anti-inflammatory, and anti-ferroptosis properties after TBI. However, whether these upregulated genes and their corresponding pathways are involved in the neuroprotective effect of MLT remains unclear. In this study, interventions to inhibit MT1/2, IL-33, and ferroptosis (i.e., ferritin H (Fth)-KO) were applied post-TBI. The results showed that MLT attenuated TBI-induced cerebral edema and neurological outcomes by inhibiting inflammation and ferroptosis. Mechanistically, MLT mainly suppressed inflammatory responses and ferroptosis via the activation of MT2 and IL-33 pathways. Building on the previous finding that Fth deletion increases susceptibility to ferroptosis post-TBI, we demonstrated that Fth depletion remarkably exacerbated the post-TBI inflammatory response, and abolished the anti-inflammatory effect of MLT in vivo and in vitro. What’s more, the post-TBI anti-inflammatory effect of MLT, which occurs by promoting the transformation of M2 phenotype macrophages, was dependent on Fth. Taken together, these results clarified that MLT alleviates inflammation- and ferroptosis-mediated brain edema and neurological deficits by activating the MT2/IL-33/Fth pathway, which provides a novel target and theoretical basis for MLT to treat TBI patients.
Morphological and metabolomics profiling of intraspecific Arabidopsis hybrids in relation to biomass heterosis
Authors: Le Quynh Thi Ngoc , Sugi Naoya , Yamaguchi Masaaki , Kobayashi Makoto , Suzuki Yutaka , Kusano Miyako , Shiba Hiroshi 
Published: January 2023

Abstract

Heterosis contributes greatly to the worldwide agricultural yield. However, the molecular mechanism underlying heterosis remains unclear. This study took advantage ofArabidopsisintraspecific hybrids to identify heterosis-related metabolites. Forty-six intraspecific hybrids were used to examine parental effects on seed area and germination time. The degree of heterosis was evaluated based on biomass: combinations showing high heterosis of F1hybrids exhibited a biomass increase from 6.1–44% over the better parent value (BPV), whereas that of the low- and no-heterosis hybrids ranged from − 19.8–9.8% over the BPV. A metabolomics analyses of F1hybrids with high heterosis and that with low-one suggested that changes in TCA cycle intermediates are key factors that control growth. Notably, higher fumarate/malate ratios were observed in the high heterosis F1hybrids, suggesting that they provide metabolic support associated with the increased biomass. These hybrids may produce more energy-intensive biomass by speeding up the efficiency of TCA fluxes. However, the expression levels of TCA-process-related genes in F1hybrids were not associated with the intensity of heterosis, suggesting that the post-transcriptional or post-translational regulation of these genes may affect the productivity of the intermediates in the TCA cycle.
Detection of complex interpersonal trauma and asset-based resilience factors in foster care youth five years or younger using latent class analysis
Authors: Tumlin Kimberly I. , Crowley Amanda , Riley Elizabeth , Turner Brian , Lyons John 
Published: January 2023

Abstract
Background: Children less than five years of age comprise the largest entry into foster care in the United State at approximately 30% in 2020. Very young children can respond differently to the same adverse life events. Detection of complex interpersonal traumas are core to providing appropriate interventions and prevention of reoccurring negative outcomes in these youth.
Methods: Children with complex interpersonal trauma and who did not have traumatic stress symptoms were identified using Child and Adolescent Needs and Strengths data in a large midwestern state from 2010 to 2021. A logistic model was fit to determine effect of cumulative traumatic exposures (e.g. adverse childhood experiences) with increased events resulting in increased likelihood of symptomatic detection. We conducted a latent class analysis to understand the relationship between traumatic experiences, asset-based factors, and the detection of traumatic stress in children aged five years and under who had exposure to traumatic events but did not have detectable traumatic stress symptoms.
Results: We detected three classes of youth described as resilient, missed, and unfolding. Very young children do demonstrate asset-based resilience when faced with traumatic experiences. A subset of children with missed diagnoses exhibit behavioral and mental health types similar to those with detected traumatic stress symptoms. Recognition of resilience in very young children is critical for designing systems that customize approaches of trauma-informed care.
Conclusions: Detection of traumatic stress may be more difficult in young children. It is important to assess both traumatic stress and strengths to ensure that children who are resilient after exposure to traumatic experiences (i.e., do not demonstrate traumatic stress symptoms) are not referred to unnecessary interventions. Additional educational approaches are needed to help caseworkers identify symptoms of traumatic stress that mirror symptoms of other behavioral and emotional challenges. Precision medicine approaches are required to best match the interventions to specific needs of young children.
How Equitable is Utilization of Maternal Health Services in Uganda? Implications for Achieving Universal Health Coverage
Authors: Atuhaire Phiona , Kiracho-Ekirapa Elizabeth , Mutenyo John 
Published: January 2023

Abstract
Background: Maternal and neonatal mortality in Uganda remain persistently high. While utilisation of and utilisation of maternal health services has been shown to reduce the risk of maternal death, little is known about the inequalities in utilisation of maternal health services. This study examined the inequalities in utilisation of maternal health services between 2006 and 2016 to draw implications for achieving universal health coverage.
Methods: We used the Uganda Demographic Health Survey 2006, 2011 and 2016 to analyse inequalities in utilisation of antenatal care (ANC4+), skilled birth attendance (SBA), postnatal care (PNC) and a package of maternal health services. Equity ratios, concentration curves, concentration indices and regression analysis were used in the estimations.
Results: Inequalities in utilization of single and a package of maternal health services reduced between 2005 and 2016, but remained pro-rich. Inequalities in utilisation of package of maternal health services were greater than for a single service. Women from the richest quintile were 4 times more likely to receive a package of care compared to the poorest women, but were just 1.5 times more likely to receive ANC4+ than those in the poorest quintile. In 2006 women in urban areas were 2.6 times more likely to receive a package of all three maternal health services than their rural counterpart and they had a relative advantage of 23.4% to utilize skilled birth delivery than the poorest women. Each additional year of schooling and living in urban areas was associated with 1.2 and 1.6 percentage point increase in utilisation of a package of care respectively. Wealth, education and living in urban areas were positively associated with utilisation of all maternal healthcare.
Conclusion: Declining inequalities in utilisation of maternal healthcare reflect a move towards achieving universal health coverage in Uganda. Pro-rich, education and urban-biased inequalities, imply the need for targeted interventions for the poor, less educated and rural women. Targeted voucher schemes, free distribution of birth kits for poorer and rural women, community-level mobilization to improve uptake of postnatal care, and promoting women’s education and incomes are feasible interventions to improve utilisation of maternal health services and equity.
Correlating the stress-strain behavior of the ring expansion technique with the conventional tensile test
Authors: Abdelgawad Khaled , Nassef Ahmed , Eraky Mohamed , Saber Mohammed 
Published: January 2023

Abstract
Background
The ring expansion technique is a non-standardized material testing used to evaluate round tubes’ mechanical properties such as burst pressure and stress-strain behavior, however, this technique has limitations such as lack of suggested specimen geometry, strain measurement technique, and friction coefficient(s) estimation.
Objective
This study primarily aims to evaluate the stress-strain property in the hoop direction for seamless pipes with a further correlation with the tensile stress-strain curve. Moreover, investigating the specimen’s geometry effect on the results was also considered throughout the study.
Methods
Experimental, simulation, and analytical techniques were carried out and through their conjunction, it was applicable to estimate hard-to-measure coefficients, identify and evaluate new correction factors, and validate the simulation and analytical results.
Results
Experimental strain measurements were performed by derived analytical equation rather than an external measuring device, novel evaluation of the hoop stress correction value (K) was performed by the comparison between experimental and simulation work, in addition to a convenient similarity between the standard tensile test and the non-conventional proposed technique results.
Conclusion
The ring expansion test is a promising technique to evaluate the seamless pipes' burst pressure, stress-strain behavior, and other mechanical properties. Furthermore, the authors recommend future work regarding estimating both pressure dissipation factor (α) in terms of friction coefficients and hoop stress correction value (K) in terms of ring’s geometry.
Persistent incisional pain at 1 year after craniotomy: a retrospective observational study
Authors: Phoowanakulchai Sirima , Ida Mitrusu , Naito Yusuke , Kawaguchi Masahiko 
Published: January 2023

Abstract
Background
There have been few reports on persistent incisional pain at 1 year after craniotomy. Hence, this study aimed to explore the distribution of pain at 1 year after elective craniotomy and its related factors.
Methods
This retrospective study included data prospectively collected to assess postoperative functional disability. We included patients aged > 55 years at the time of recruitment for our initial study and who had complete data regarding the pain numeric rating scale (NRS) score at 1 year post craniotomy. The primary outcome was the pain NRS score, which was assessed at the postanesthetic clinic as well as at 3 months and 1 year after craniotomy. Multivariable negative binomial regression analysis was performed to analyze the relationship between the pain NRS score at 1 postoperative year and 12 clinically meaningful covariates. These included the Short Form-8 scores for bodily pain and mental health, with higher scores indicating better health.
Results
We analyzed data from 102 patients. The mean (95% confidence interval) pain NRS scores at the three measurement points were 2.8 (2.3–3.3), 1.2 (0.8–1.6), and 0.6 (0.3–0.8), respectively. Multivariable analysis revealed that preoperative bodily pain (risk ratio, 0.93; 95% confidence interval, 0.88–0.98) and the pain NRS score at the postanesthetic clinic (risk ratio, 1.32; 95% confidence interval, 1.14–1.52) were associated with the risk of persistent pain at 1 postoperative year.
Conclusions
The pain score at 1 year after elective craniotomy was minor; however, preoperative bodily pain and postoperative pain scores were significantly related factors.
The Relationship Between Attachment Styles and Loneliness: The Mediating Role of Early Maladaptive Schemas
Authors: Jalilian Kosar , Momeni Khodamorad , Jebraeili Hashem 
Published: January 2023

Abstract
As with the increasing prevalence of loneliness among college students, it seems necessary to investigate the early grounds of its formation. Therefore, the present study was conducted to investigate the relationship between attachment styles and loneliness through the mediating role of early maladaptive schemas (EMS). This was a correlational research, of structural equations modeling (SEM) type. The statistical population included all the college students of the universities of Kermanshah in the academic year 2020–2021, of whom 338 were selected using convenience sampling. The measures used in this study included DiTomasso et al’s social and emotional loneliness of adults, Hazan and Shaver’s adult attachment, and Young’s schema scales. For data analysis, Pearson’s correlation coefficient and SEM were used in Lisrel 8.8 and SPSS-22 software. The results illustrated that the hypothesized model of the study has a good fit in the studied sample. It was also found that both the avoidant and ambivalent attachment styles are related to loneliness through two EMS of disconnection-rejection and other-directedness. Based on this, measures are recommended to increase information regarding the basic and underlying factors affecting loneliness for therapists and psychological specialists.