bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small non‐coding RNA profiling in patients with gastrointestinal cancer
Authors: Molfino Alessio , Beltrà Marc , Amabile Maria Ida , Belli Roberta , Birolo Giovanni , Belloni Elena , De Lucia Serena , Garcia‐Castillo Lorena , Penna Fabio , Imbimbo Giovanni , Nigri Giuseppe , Pardini Barbara , Costelli Paola , Muscaritoli Maurizio 
Published: September 2023

AbstractBackgroundSmall non‐coding (snc)RNAs, including microRNAs and P‐element induced wimpy testis (PIWI)‐interacting‐RNAs (piRNAs), crucially regulate gene expression in both physiological and pathological conditions. In particular, some muscle‐specific microRNAs (myomiRs) have been involved in the pathogenesis of cancer‐induced muscle wasting. The aims of the present study were (i) to profile sncRNAs in both skeletal muscle and plasma of gastrointestinal cancer patients and (ii) to investigate the association among differentially expressed sncRNAs and the level of muscularity at body composition analysis.MethodsSurgical patients with gastrointestinal cancer or benign disease were recruited. Blood samples and muscle biopsies (rectus abdominis) were collected during surgery. Low muscularity patients were those at the lowest tertile of skeletal muscle index (SMI; CT‐scan), whereas moderate/high muscularity patients were in the middle and highest SMI tertiles. SncRNAs in the muscle were assessed by RNAseq, circulating microRNAs were evaluated by qPCR.ResultsCancer patients (n = 25; 13 females, 52%) showed a mean age of 71.6 ± 11.2 years, a median body weight loss of 4.2% and a mean BMI of 27.0 ± 3.2 kg/m2. Control group (n = 15; 9 females, 60%) showed a mean age 58.1 ± 13.9 years and a mean BMI of 28.0 ± 4.3 kg/m2. In cancer patients, the median L3‐SMI (cm2/m2) was 42.52 (34.42; 49.07). Males showed a median L3‐SMI of 46.08 (41.17–51.79) and females a median L3‐SMI of 40.77 (33.73–42.87). Moderate‐high and low muscularity groups included 17 and 8 patients, respectively. As for circulating microRNAs, miR‐21‐5p and miR‐133a‐3p were up‐regulated in patients compared with controls, whereas miR‐15b‐5p resulted down‐regulated in the same comparison (about 30% of control values). Sample clustering by muscularity and sex revealed increased miR‐133a‐3p and miR‐206 only in moderate‐high muscularity males. SncRNA profiling in the muscle identified 373 microRNAs and 190 piRNAs (72.5% and 18.7% of raw reads, respectively). As for microRNAs, 10 were up‐regulated, and 56 were down‐regulated in cancer patients versus controls. Among the 24 dysregulated piRNAs, the majority were down‐regulated, including the top two most expressed piRNAs in the muscle (piR‐12790 and piR‐2106). Network analysis on validated mRNA targets of down‐regulated microRNAs revealed miR‐15b‐5p, miR‐106a‐5p and miR‐106b‐5p as main interactors of genes related to ubiquitin ligase/transferase activities.ConclusionsThese results show dysregulation of both muscle microRNAs and piRNAs in cancer patients compared with controls, the former following a sex‐specific pattern. Changes in circulating microRNAs are associated with the degree of muscularity rather than body weight loss.
Appendicitis in pregnant women: A systematic review and meta‐analysis of the diagnostic performance of ultrasonography
Authors: Wang Zimo , Bao Fuxing , Liang Weiyu , Wu Huaiyu , Lin Ziwei , Xu Jinfeng , Dong Fajin 
Published: September 2023

AbstractObjectivesThe accuracy of ultrasound in the detection of appendicitis in pregnant women was examined in a meta‐analysis.MethodsPregnant women with suspected acute appendicitis were evaluated using ultrasound in a systematic search of PubMed, EMBASE, and Cochrane Library databases from January 1, 2011 to August 10, 2023. The sensitivity and specificity values and diagnostic odds ratios were obtained using the pooled data.ResultsA total of 239 patients were studied in four relevant investigations. Ultrasonography has a sensitivity of 56% and a specificity of 88% for the diagnosis of acute appendicitis, with an area under the receiver operating characteristic curve of 0.66%. Ultrasonography had a positive likelihood ratio of 4.65 (95% confidence interval, 1.42–15.23) and a negative likelihood ratio of 0.50 (95% confidence interval, 0.41–0.62). There was no evidence of publication bias (p = 0.93).ConclusionsUltrasound has moderate sensitivity for identifying appendicitis in pregnant women and may be utilized as an alternative diagnostic method.
Randomized phase II trial of chemoradiotherapy with S‐1 versus combination chemotherapy with gemcitabine and S‐1 as neoadjuvant treatment for resectable pancreatic cancer (JASPAC 04)
Authors: Sugiura Teiichi , Toyama Hirochika , Fukutomi Akira , Asakura Hirofumi , Takeda Yuriko , Yamamoto Kouji , Hirano Satoshi , Satoi Sohei , Matsumoto Ippei , Takahashi Shinichiro , Morinaga Soichiro , Yoshida Makoto , Sakuma Yasunaru , Iwamoto Hidetaka , Shimizu Yasuhiro , Uesaka Katsuhiko 
Published: September 2023

AbstractObjectiveThe aim of the present study was to investigate which treatment, neoadjuvant chemoradiotherapy (NAC‐RT) with S‐1 or combination neoadjuvant chemotherapy with gemcitabine and S‐1 (NAC‐GS), is more promising as neoadjuvant treatment (NAT) for resectable pancreatic cancer in terms of effectiveness and safety.MethodsIn the NAC‐RT with S‐1 group, the patients received a total radiation dose of 50.4 Gy in 28 fractions with oral S‐1. In the NAC‐GS group, the patients received intravenous gemcitabine at a dose of 1000 mg/m2 with oral S‐1 for two cycles. The primary endpoint was the 2‐year progression‐free survival (PFS) rate. The trial was registered with the UMIN Clinical Trial Registry as UMIN000014894.ResultsFrom April 2014 to April 2017, a total of 103 patients were enrolled. After exclusion of one patient because of ineligibility, 51 patients were included in the NAC‐RT with S‐1 group, and 51 patients were included in the NAC‐GS group in the intention‐to‐treat analysis. The 2‐year PFS rate was 45.0% (90% confidence interval [CI]: 33.3%–56.0%) in the NAC‐RT with S‐1 group and 54.9% (42.8%–65.5%) in the NAC‐GS group (p = .350). The 2‐year overall survival rate was 66.7% in the NAC‐RT with S‐1 group and 72.4% in the NAC‐GS group (p = .300). Although leukopenia and neutropenia rates were significantly higher in the NAC‐GS group than in the NAC‐RT with S‐1 group (p = .023 and p < .001), other adverse events of NAT and postoperative complications were comparable between the two groups.ConclusionBoth NAC‐RT with S‐1 and NAC‐GS are considered promising treatments for resectable pancreatic cancer.
Two‐step artificial intelligence algorithm for liver segmentation automates anatomic virtual hepatectomy
Authors: Kazami Yusuke , Kaneko Junichi , Keshwani Deepak , Kitamura Yoshiro , Takahashi Ryugen , Mihara Yuichiro , Ichida Akihiko , Kawaguchi Yoshikuni , Akamatsu Nobuhisa , Hasegawa Kiyoshi 
Published: September 2023

AbstractBackgroundAnatomic virtual hepatectomy with precise liver segmentation for hemilivers, sectors, or Couinaud's segments using conventional three‐dimensional simulation is not automated and artificial intelligence (AI)‐based algorithms have not yet been applied.MethodsComputed tomography data of 174 living‐donor candidates for liver transplantation (training data) were used for developing a new two‐step AI algorithm to automate liver segmentation that was validated in another 51 donors (validation data). The Pure‐AI (no human intervention) and ground truth (GT, full human intervention) data groups were compared.ResultsIn the Pure‐AI group, the median Dice coefficients of the right and left hemilivers were highly similar, 0.95 and 0.92, respectively; sectors, posterior to lateral: 0.86–0.92, and Couinaud's segments 1–8: 0.71–0.89. Labeling of the first‐order branch as hemiliver, right or left portal vein perfectly matched; 92.8% of the second‐order (sectors); 91.6% of third‐order (segments) matched between the Pure‐AI and GT data.ConclusionsThe two‐step AI algorithm for liver segmentation automates anatomic virtual hepatectomy. The AI‐based algorithm correctly divided all hemilivers, and more than 90% of the sectors and segments.
Island idleness: Investigating the impact of remittances on labour market participation in Comoros
Authors: Keller Michael , Mulangu Francis 
Published: September 2023

AbstractThe labour market is fundamental for economic growth, which makes an in‐depth understanding of its dynamics crucial for development and poverty reduction. One determinant of labour market outcomes are remittances. Remittances can influence the decision of an individual whether to participate in the labour market or not, which makes it necessary to understand this relation. In this study we assessed the impact of remittances on the labour supply in the Comoros, the second largest recipient of remittances as a percentage of Gross Domestic Product (GDP) in Africa, by using propensity score matching and national household surveys for 2014 and 2020 to estimate how remittances influenced the decision to participate in the labour market. Most of our results are statistically insignificant; that is, individuals receiving remittances were as likely to participate in the labour market as non‐receivers. Remittances did not influence the unemployment rate and the number of hours worked. On the other side, we found that the type of work was influenced overall by remittances with remittances receivers being more likely to engage in informal work, being more likely to be self‐employed and finally being less likely to engage in wage work. We further find some heterogeneity across the origin and the amount of received remittances. Foreign remittances can explain better the few significant results than domestic remittances and high remittances receivers influenced the labour participation rate, while low and medium remittances receivers explain better the impact of remittances on hours worked, self‐employment and wage work.
Radial Planes in Hip Magnetic Resonance Imaging: Techniques, Applications, and Perspectives
Authors: Chen Yan‐Li , Chen Wei 
Published: September 2023

The hip cartilage and labrum, as the main targets of femoroacetabular impingement, sports‐related or traumatic damage, as well as congenital and developmental abnormalities, have attracted increasing attention with the development of magnetic resonance imaging (MRI) and hip arthroscopy. MRI is a commonly used imaging modality to noninvasively visualize the hip cartilage and labral lesions. However, conventional orthogonal MRI planes encounter unique challenges given the ball‐and‐socket configuration of the hip joint, its anatomically abducted and anteverted orientation, and the thin, closely apposed cartilage enveloping the femoral head and acetabulum. Advancements in hip MRI's radial plane, which is acquired through the center of the hip joint, offer a solution. This technology provides true cross‐sectional images of the cartilage and labrum perpendicular to the curvature of the joint, thereby mitigating the partial‐volume‐averaging effects. The integration of 3.0‐Tesla high field strength and three‐dimensional (3D) acquisition techniques further enhances the capabilities of the radial plane. This combination yields a high signal‐to‐noise ratio, high spatial resolution, high contrast between intraarticular structures, while minimizing partial‐volume‐averaging effects. Such improvements potentially facilitate the comprehensive detection of even minor chondral and labral lesions. The capability for multiplanar reconstruction from a single 3D volumetric acquisition further strengthens the usefulness of the radial plane by aiding in precise localization of hip cartilage and labral lesions, in line with hip arthroscopy findings. These advancements have the potential to standardize MRI evaluations and radiographic reporting systems for hip cartilage and labrum, offering precise guidance for hip arthroscopy. This article presents a comprehensive review of radial plane technology applied to the hip MRI, and discusses the morphological assessment and localization of hip cartilage and labral lesions utilizing this advanced imaging technique.Evidence Level5Technical EfficacyStage 2
The Japanese Catheter Ablation Registry (J‐AB): Annual report in 2021
Authors: Kusano Kengo , Yamane Teiichi , Inoue Koichi , Takegami Misa , Nakai Michikazu , Kanaoka Koshiro , Tonegawa‐Kuji Reina , Miyamoto Koji , Iwasaki Yu‐ki , Takatsuki Seiji , Nakamura Kohki , Iwanaga Yoshitaka , Shimizu Wataru ,   J‐AB registry investigators
Published: September 2023

AbstractThe Japanese Catheter Ablation (J‐AB) registry, started in August 2017, is a voluntary, nationwide, multicenter, prospective, observational registry, performed by the Japanese Heart Rhythm Society (JHRS) in collaboration with the National Cerebral and Cardiovascular Center using a Research Electronic Data Capture system. The purpose of this registry is to collect the details of target arrhythmias, the ablation procedures, including the type of target arrhythmias, outcomes, and acute complications in the real‐world settings. During the year of 2021, we have collected a total of 89 609 procedures (mean age of 66.1 years and 65.9% male) from 506 participant hospitals. Detailed data are shown in Figures and Tables.
Comparative transcriptome and metabolome analyses revealed quality difference between beauty tea processed through indoor withering and outdoor solar withering
Authors: Ding Fengjiao , Zhang Yunzhi , Lin Jinlong , Zhong Sitong , Li Pengchun , Li Yuanchao , Chen Chunmei , Jin Shan 
Published: September 2023

AbstractBackgroundWithering is the first processing procedure of beauty tea, and there are few reports on the impact of withering methods on the quality of beauty tea and its regulatory mechanisms.ResultsThrough comparison of fresh tea leaves (FT) with the leaves after indoor natural withering for 18 h (IWT‐18) and outdoor solar withering for 6 h (OWT‐6), which were collected at the end of the two withering processes, 17 282 and 13 984 differentially expressed genes (DEGs) were respectively screened and 267 and 154 differential metabolites (DMs) were respectively identified. The coexpression network revealed that a large number of DEGs and DMs were enriched in phenylpropanoid, flavonoid, and adenosine triphosphate binding cassette (ABC) transporter pathways, and the number of DMs and DEGs in IWT‐18 versus FT exceeded that in OWT‐6 versus FT. Both withering methods promoted a significant increase in content of phenylalanine and upregulation of β‐glucoside expression in the phenylpropanoid metabolism pathway. Five theaflavin‐type proanthocyanidins in the flavonoid synthesis pathway were more significantly accumulated in FT versus IWT‐18 than in FT versus OWT‐6. Meanwhile, both withering methods can affect the ABC transporter pathway to promote the accumulation of amino acids and their derivatives, but different withering methods affect different ABC transporter families. Outdoor withering with more severe abiotic stress has a greater impact on the ABCG family, whereas indoor withering has a more significant effect on the ABCC family. Sensory evaluation results showed that the dry tea of IWT‐18 was slightly better than that of OWT‐6 because of the longer withering time and more thorough substance transformation.ConclusionIn conclusion, the formation of honey flavor in beauty tea may be closely related to the DEGs and DMs in these three pathways. Our research provides theoretical data support for further revealing the mechanism of quality formation during the withering process of beauty tea. © 2023 Society of Chemical Industry.
Quality of Office‐based Procedure Training During Laryngology Fellowship
Authors: Enver Necati , Axiotakis Lucas G. , Sulica Lucian , Pitman Michael J. 
Published: September 2023

ObjectivesThe primary objective was to assess the perspectives of recent laryngology fellowship graduates on office‐based procedure training, with a secondary objective to compare this with previous research on perspectives of fellowship directors.MethodsRecent laryngology fellowship graduates were surveyed via an online survey platform regarding post‐fellowship practice and various aspects of office‐based procedure training, including perceived competence, mentorship, and barriers.ResultsThere were 51 respondents. Seventy‐six percent of respondents felt they “definitely” received adequate office procedure training. Number of procedures as primary surgeon was significantly associated with perception of adequate training (OR 1.54, 95% CI: 1.08–2.19, p = 0.018) and high post‐fellowship office procedure volume (OR 1.56, 95% CI: 1.02–2.39, p = 0.040). Fellows reported a lower percentage of procedures as primary surgeons compared with program directors (46.8% vs. 61.9%, p = 0.028). Fellows and directors agreed that informal debriefs were more commonly employed than more structured training elements such as checklists and simulators. Of nine office procedures, laryngeal electromyography, KTP laser, and transnasal esophagoscopy had the greatest decreases in practice after training.ConclusionAlthough most recent laryngology fellowship graduates endorse adequate office‐based procedure training, a range of individual experiences exists, and office procedure volume, both overall and across individual procedures, may decrease after fellowship. Fellows performing office procedures as primary surgeons may be linked to perceived quality of training and post‐fellowship volume.Level of EvidenceNA Laryngoscope, 134:1802–1806, 2024
Mechanochemical Activation of a Metal–Organic Framework Embedded within a Thermoplastic Polyurethane Matrix: Probing Fluorogenic Stress‐Sensing
Authors: Shinde Kshitij Sanjay , Michael Philipp , Binder Wolfgang H. 
Published: September 2023

AbstractHere, a mechanochemically triggered Cu(I) bis(N‐heterocyclic carbene [NHC))‐based metal–organic framwork (MOF) embedded into a thermoplastic polyurethane (TPU)‐matrix is reported. The induced fluorogenic copper‐catalyzed azide–alkyne cycloaddition (CuAAC) reveals the stressed parts within the thermoplastic PU via a simple optical detection. As determined via oscillating tensile rheology on dumbbell‐shaped samples of TPU, a MOF, containing 4.66% copper, catalyzes the fluorogenic CuAAC between the nonfluorescent precursor dyes, 8‐azidonaphthalen‐2‐ol, and 3‐hydroxyphenylacetylene. After mechanical activation of the MOF situated inside the TPU, the fluorescent 8‐(4‐(3‐hydroxyphenyl)‐1,2,3‐triazol‐1‐yl)naphthalen‐2‐ol dye is formed. Monitoring the formation of the dye inside the TPU via fluorescence spectrometry at λex = 458 nm shows an increase of the fluorescence intensity up to 60–70%. It is demonstrated that a dumbbell‐shaped TPU, subjected to higher stress, displays higher fluorescence than the surrounding other areas, thus effectively functioning as a three‐in‐one stress‐sensor system.
Marketing analytics: The bridge between customer psychology and marketing decision‐making
Authors: Basu Rituparna , Lim Weng Marc , Kumar Anil , Kumar Satish 
Published: September 2023

AbstractAs modern marketing environments become increasingly data‐intensive, the role of marketing analytics in illuminating the dynamics of customer psychology to inform marketing decision‐making becomes critical. This study conducts a systematic literature review using a bibliometric analysis of 122 studies identified and retrieved from Scopus, focusing on the expansive domain of marketing analytics. Our review serves as a conduit binding the fragmented past, present, and future of marketing analytics, presenting an organized framework that highlights the characteristic theoretical underpinnings associated with it. Beyond offering a panoramic perspective of key resources—encompassing journals, authors, countries/territories, and institutions—we delve deeply into predominant themes in marketing analytics. These themes underscore its vital applications, from decision‐making, forecasting, and capability building, to understanding customer journeys and gaining a competitive edge. Central to our discourse is the study's implication, emphasizing marketing analytics as a bridge to a more informed grasp of customer psychology in today's customer‐centric, data‐driven environment. Through this lens, marketing analytics becomes a potent tool to capture psychological nuances, uncovering facets that might be bypassed by traditional marketing, thereby empowering enriched decision‐making in modern marketing strategies.
A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity
Authors: Tang Xiaoxiao , Feng Chengyun , Zhao Yuxi , Zhang Huajie , Gao Yan , Cao Xueshan , Hong Qi , Lin Jing , Zhuang Hongbin , Feng Yuying , Wang Hanghang , Shen Liming 
Published: September 2023

AbstractGenetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted a plasma proteomic and metabolomic study of children with ASD with and without risk genes (de novo mutation) and controls to explore the impact of genetic heterogeneity on the search for biomarkers for ASD. In terms of the proteomic and metabolomic profiles, the groups of children with ASD carrying and those not carrying de novo mutation tended to cluster and overlap, and integrating them yielded differentially expressed proteins and differential metabolites that effectively distinguished ASD from controls. The mechanisms associated with them focus on several common and previously reported mechanisms. Proteomics results highlight the role of complement, inflammation and immunity, and cell adhesion. The main pathways of metabolic perturbations include amino acid, vitamin, glycerophospholipid, tryptophan, and glutamates metabolic pathways and solute carriers‐related pathways. Integrating the two omics analyses revealed that L‐glutamic acid and malate dehydrogenase may play key roles in the pathogenesis of ASD. These results suggest that children with ASD may have important underlying common mechanisms. They are not only potential therapeutic targets for ASD but also important contributors to the study of biomarkers for the disease.
Meta‐analysis of Association between Newer Glucose‐Lowering Drugs and Risk of Parkinson's Disease
Authors: Tang Huilin , Lu Ying , Okun Michael S. , Donahoo William T. , Ramirez‐Zamora Adolfo , Wang Fei , Huang Yu , Chen Wei‐Han , Virnig Beth A. , Bian Jiang , Guo Jingchuan 
Published: September 2023

ABSTRACTBackgroundThe association between newer classes of glucose‐lowering drugs (GLDs) and the risk of Parkinson's disease (PD) remains unclear.ObjectiveThe aim was to examine the effect of newer GLDs on the risk of PD through a meta‐analysis of randomized outcome trials.MethodsThe methods included randomized placebo‐controlled outcome trials that reported PD events associated with three newer classes of GLDs (ie, dipeptidyl peptidase‐4 inhibitors, glucagon‐like peptide‐1 receptor agonists, and sodium‐glucose co‐transporter‐2 inhibitors) in participants with or without type 2 diabetes. The pooled odds ratio (OR) and 95% confidence interval (CI) were estimated using Peto's method.ResultsThe study included 24 trials involving 33 PD cases among 185,305 participants during a median follow‐up of 2.2 years. Newer GLDs were significantly associated with a lower PD risk (OR: 0.50; 95% CI: 0.25–0.98) than placebo.ConclusionNewer GLDs may possibly be associated with a decreased risk of PD; however, larger datasets are required to confirm or refute this notion.