bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penjadwalan Ulang Pekerjaan Finishing Proyek Shangrila Hotel Resort and Spa Menggunakan Metode PERT dan FLASH
Authors: Trisiana Anita , Arifin Syamsul , Effendy Khoirunnisai 
Published: February 2023

A construction project in general always applies the concept of project management. The components of a construction project's success include cost, quality, and time. Planning and management of detailed scheduling of activities are necessary to complete a project to get the most optimal results within a predetermined time period. In the Shangrila Hotel Resort and Spa project, the remaining work is building finishing. The percentage of project completion was still at 3% in July 2019, so in this condition, rescheduling was carried out with the right approach to determine the project time. The Shangrila Hotel, Resort, and Spa project rescheduling use the PERT and FLASH methods. This method uses a probability percentage rather than uncertainty probability when analyzing project completion time. The rescheduling period is 272 days. The PERT method analysis based on activities on the critical path produces a probability percentage of 79.39%. Analysis of the FLASH method by considering all project activity relationships resulted in a probability percentage of 90%. In making a schedule, you can use modifications from other project management applications, such as BIM (Building Information Modeling).
ABSTRAK
Pada umumnya proyek konstruksi selalu menerapkan konsep manajemen proyek. Faktor keberhasilan suatu proyek kontruksi antara lain faktor biaya, mutu, dan waktu. Perencanaan dan manajemen penjadwalan terperinci tentang aktivitas kegiatan sangat diperlukan untuk menyelesaikan suatu proyek yang bertujuan untuk mendapatkan hasil yang paling optimal dalam jangka waktu yang telah ditentukan. Pada proyek Shangrila Hotel Resort and Spa memiliki pekerjaan proyek yang tersisa adalah pekerjaan finishing gedung. Persentase penyelesaian proyek masih 3% pada bulan Juli 2019, maka dalam kondisi ini dilakukan penjadwalan ulang dengan pendekatan yang tepat untuk menentukan waktu proyek. Penjadwalan ulang pada proyek Shangrila Hotel Resort and Spa menggunakan metode PERT dan FLASH. Metode ini menggunakan persentase posibilitas daripada probabilitas ketidakpastian ketika menganalisis waktu penyelesaian proyek. Penjadwalan ulang yang direncanakan adalah 272 hari. Analisa metode PERT berdasarkan kegiatan pada lintasan kritisnya menghasilkan persentase probabilitas sebesar 79,39%. Analisa metode FLASH dengan mempertimbangkan seluruh hubungan kegiatan proyek menghasilkan persentase posibilitas sebesar 90%. Dalam membuat rencana penjadwalan dapat menggunakan modifikasi aplikasi Manajemen Proyek yang lain seperti BIM (Building Information Modeling).
Inadvertent obstacle contacts when older adults step over obstacles: Effect of sex, self-reported fatigue, gait parameters, and prescription medications
Authors: Becker Timothy , Rietdyk Shirley 
Published: February 2023

Background: Tripping is a common cause of falls, but the factors that are associated with trip risk are understudied.
Aim: To quantify inadvertent trips with a stationary, visible obstacle in older adults, and to determine how inadvertent trips are related to fatigue, sex, gait measures, and prescription medications.
Methods: Forty-one subjects walked on a 6 m walkway and stepped over a visible, stationary obstacle (height: 25% of leg length) 100 times; inadvertent trips with the obstacle were documented. We also collected gait measures on a clear walkway, self-reported fatigue every 25 obstacle crossing trials, and number of prescription medications. Participants were categorized as: 0 contacts or ≥1 contact.
Results: The obstacle was contacted by 15 participants (37%) in 29 trials (0.7% of all trials); 52% of contacts were with the lead limb. Self-reported fatigue increased during the obstacle crossing protocol (p<0.001). Participants in the ≥1 contact group had slower gait speed, shorter stride length, and higher gait cycle time variability (p≤0.041). They also reported higher maximum fatigue (p=0.022) and a higher number of prescription medications (p=0.019). Males and females were not different in contact frequency (p=0.93).
Interpretation: Inadvertent trips were not uncommon in older adults, even with a visible, stationary obstacle. Lead limb contacts indicate that older adults will have more difficulty recovering their balance after a trip. The strong association between fatigue (induced by walking) and impaired gait is highly relevant when quantifying gait in older adults, and also when developing fall prevention programs.
Expert System for Diagnosing Cow Disease Using Web-Based Forward Chaining Method
Authors: Ma'ruf Mohammad Rizal , Eviyanti Ade 
Published: February 2023

Media Technology and Information is currently developing quite quickly and well. Some people and even almost all of the surrounding community are familiar with technology, especially in the science of artificial intelligence. With this expert system, it can help alleviate the need when it is difficult to meet experts, especially livestock specialist diseases. The purpose and benefits of this expert system is to make it easier for researchers to identify livestock disease problems based on the symptoms suffered by cattle. The identification method used in this system is the Forward Chaining Method and collects symptom data from several sources and verified journals. The desired result of this research is the reduction of disease or outbreaks that occur in Livestock Cattle
and provide prevention and treatment solutions so as not to be attacked by diseases and outbreaks..
A Genetics Based Makespan Optimizer with Knowledge Augmented Fuzzy Probabilities
Authors: Gupta Sachi , Iyer Sailesh , Agarwal Gaurav , Elngar Ahmed A. 
Published: February 2023

Abstract
Scheduling of various tasks in the multiprocessor environment has been a source of difficult problems for researchers in the field of computer engineering. The widespread issue of multiprocessor task scheduling can be explained as scheduling tasks onto processors and ordering their execution so that several performance standards can be improved. The nondeterministic polynomial-time (NP) completeness of the task scheduling problem has motivated researchers to suggest a variety of heuristic algorithms that can achieve suboptimal results in a reduced amount of polynomial time. Recently, genetic algorithms (GA) have received a lot of responsiveness as GAs are robust and give assurance of a better-quality solution. The outcomes of the experiments carried out with scheduling problems illustrate that genetic algorithms are superior to heuristic algorithms concerning the quality of their outcomes, but they are noticeably slower than heuristic algorithms concerning running time. To overcome the issues related to heuristic algorithms and genetic algorithms, a new approach is proposed in this research work, which combines a GA with various types of scheduling heuristics. In GA, the crossover and mutation rates are the control parameters that need to be set carefully to get optimal results. Generally, these key factors are left to the GA users, but in this research work, a GA that adopts a fuzzy knowledge-based system to control GA key factors has been proposed. To analyze the efficiency of the proposed method, various tests have been performed by varying the number of generations and by analyzing the variations in average schedule length. Based on the findings, the suggested hybrid algorithm is capable of competing with conventional scheduling algorithms in terms of increased quality of outcomes.
Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
Authors: Zhao Yuwan , Lin Xinghua , Zeng Wenfeng , Qin Xingzhang , Miao Bailiang , Gao Sheng , Liu Jianjun , Li Zhuo 
Published: February 2023

Abstract
Background Berberine is a natural isoquinoline alkaloid that has been shown to have antitumor properties in a growing number of studies. However, its role in renal cell carcinoma remains unclear. This study investigates berberine's effect and mechanism in renal cell carcinoma.
Methods The methyl-tetrazolium, colony formation, and lactate dehydrogenase assay were used to detect proliferation and cytotoxicity, respectively. Flow cytometry, caspase-Glo 3/7 assay, and adenosine triphosphate assay were used to detect apoptosis and the adenosine triphosphate levels. Wound healing and transwell assay were used to examine the migration ability of renal cell carcinoma cells. Besides, the level of reactive oxygen species (ROS) was explored using a DCFH-DA-based kit. Additionally, western blot and Immunofluorescence assay was taken to determine the levels of relative proteins.
Results In vitro, our findings indicated that the proliferation and migration of renal cell carcinoma cells treated with berberine in various concentrations were inhibited, while the level of ROS and apoptosis rate were increased. Furthermore, The results of western blot showed that the expression of Bax, Bad, Bak, Cyto c, Clv-Caspase 3, Clv-Caspase 9, E-cadherin, TIMP-1and γH2AX were up-regulated, while Bcl-2, N-cadherin, Vimentin, Snail, Rad51 and PCNA were down-regulated after treating with berberine with various concentration.
Conclusion The result of this study revealed that berberine inhibits renal cell carcinoma progression via regulating ROS generation and inducing DNA break.
Serial measurement should be used to ascertain a diagnosis of microcephaly
Authors: Sengasai Chutima , Chokephaibulkit Kulkanya , Plipat Nottasorn , Wongsiridej Pimol 
Published: February 2023

Abstract
Background: Birth process may affect head size of newborns. A single measurement of maximum occipitofrontal circumference at birth or within 24 hours may lead to under or over diagnosis of congenital microcephaly. The study objectives are 1) to compare head circumferences (HC) at birth, and at day 3 of life, and 2) to evaluate maternal and infant factors associated with increased head circumference by day 3 of life.
Method: We conducted a prospective study of 1,131 live births with gestational age over 27 weeks between February and May 2019. All newborns had their HC measured at birth and at day 3 before discharge by trained personnel. The measurement device was similar throughout the study. The WHO and Fenton Growth Charts were used as reference ranges for interpretation.
Results: The mean (+/- SD) HC within 24 hours of life and at day 3 of life were 33.58 (+/- 1.53) cm and 33.75 (+/- 1.37) cm. The mean differences were statistically significant, i.e. 0.17 cm (p<0.001). Of the 32 newborns with HC in the range of microcephaly at birth, 25 (78%) had normalized HC at day 3 of life. After adjusting for mode and presentation of delivery, newborns whose mother experienced labor pain (β=0.31, P <0.001) and newborns being either symmetrical SGA or asymmetrical SGA (β= 0.59, P = 0.002; β= 0.37, P = 0.03) had statistically significant increased HC at day 3 of life. Newborns whose mothers experienced labor pain had 0.31 cm increase in HC at day 3 of life when compared to the HC at birth, while symmetrical SGA newborn also had an average of 0.59 cm increased. Parity and gestational age were not associated factors with changes of HC.
Conclusion: Serial HC measurement is necessary to ascertain a diagnosis of microcephaly.
Clinical Trial Registry: Ethical approval for this study was obtained from the Research Ethics Board at Siriraj Hospital, with the Reference Number Si650/2018. Written parental informed consent was obtained before HC measurement.
The Food Plants Trade in The Kranggan Mas Traditional Market, West Java Province, Indonesia: Potential and Local Cuisine
Authors: Silalahi Marina , Wakhidah Anisatu Z 
Published: February 2023

Abstract
The market is the main place for buying and selling alternative food ingredients and is rich in local wisdom. This study aims to explain the diversity of food plants and alternative foods that are traded in the Kranggan Mas traditional market, Bekasi and their potential as healthy food ingredients. The research was conducted with an ethnobotanical approach with surveys, interviews and observations. Respondents in the study were all traders who traded alternative food ingredients. Qualitative analysis includes grouping plants based on benefits, families, and parts used. There were 143 species belonging 105 genera and 46 families of food plants that were traded at the Kranggan Mas traditional market. Most of the plants are used as vegetables (51 species), followed by fruit sources (45 species) and followed by cooking spices (38 species) and alternative food (12 species). A total 128 species have been cultivated and 10 species are wild. The availability of diversity of food plants in traditional markets has an impact on the preservation of traditional foods of the surrounding community, such as sayur asem (Betawi ethnicity), pecel (Javanese ethnicity), and lalab (Sundanese ethnicity). Supply and development of food, especially wild and semi-cultivated plants such as Dioscorea spp. and Arthocarpus sp. need to be studied further so that preservation and healthy food can be improved.
Oral Pre-Exposure Prophylaxis (PrEP) Awareness and Acceptability Among Persons who Inject Drugs (PWID) in Kenya: A Qualitative Investigation
Authors: Cosmas Mugambi , Loice Mbogo , William Sinkele , Esther Gitau , Carey Farquhar , Tecla Temu , David Bukusi , John Kinuthia , Aliza Monroe-Wise 
Published: February 2023

Abstract

Background:People who inject drugs (PWID) are disproportionately affected by HIV despite the availability of multiple efficacious biomedical prevention interventions including oral pre-exposure prophylaxis (PrEP). Little is known about the knowledge, acceptability, and uptake of oral PrEP among this population in Kenya. To inform the development of oral PrEP uptake optimization interventions for PWID in Kenya, we conducted a qualitative assessment to establish oral PrEP awareness and willingness to take PrEP by this group in Nairobi City.Methodology:Guided by the Capability, Opportunity, Motivation, and Behaviour (COM-B) model of health behavior change, we conducted8 focus group discussions (FGDs) among randomly constituted samples of PWID in four harm reduction drop-in centers (DICs) in Nairobi in January 2022. The domains explored were: perceived risks (behaviour), oral PrEP awareness and knowledge (capability), motivation to use oral PrEP (behaviour), and perceptions on community uptake (motivation and opportunity). Completed FGD transcripts were uploaded to Atlas.ti version 9 and thematic analysis was conducted through an iterative process of review and discussion by two coders.Findings:There was a low level of oral PrEP awareness with only 4 of the 46 PWID having heard of PrEP; only 3 out of 46 participants had ever used oral PrEP and 2 out of 3 were no longer using it, indicating a low capacity to make decisions on oral PrEP. Most study participants were aware of the risk posed by unsafe drug injection and expressed willingness to take oral PrEP. Nearly all participants demonstrated low understanding of the role oral PrEP plays in complementing condoms in HIV prevention, presenting an opportunity for awareness creation. While the PWID were eager to learn more about oral PrEP, they favored DICs as places where they would like to obtain information and oral PrEP if they chose to use it, identifying an opportunity for oral PrEP programming interventions.Conclusion:Creation of oral PrEP awareness among PWID in Kenya is likely to improve uptake since the PWID are receptive. Oral PrEP should be offered as part of combination prevention approaches, and effective messaging through DICs, integrated outreaches, and social networks are recommended to mitigate displacement of other prevention and harm reduction practices by this population.Trial Registration:ClinicalTrials.gov Protocol Record STUDY0001370.
Effects of KIR2DL4-Stimulated NK-92 Cells on the Apoptotic Pathways of HER2+/HER2- Breast Cancer Cells
Authors: Kilic Nil , Dastouri Mohammadreza , Kandemir Irfan , Yilmaz Erkan 
Published: February 2023

Abstract
Natural killer (NK) cells are immune cells that have attracted significant attention due to their cytotoxic properties. They are believed to be highly effective in cancer therapy. In this study, anti-KIR2DL4 (Killer cell Immunoglobulin like Receptor, 2 Ig Domains and Long cytoplasmic tail 4) was used to stimulate the NK-92 activator receptor to increase their cytotoxicity on breast cancer cell lines. Unstimulated and stimulated NK-92 cells (sNK-92) were cocultured with breast cancer (MCF-7 and SK-BR-3) and normal breast (MCF-12A) cell lines at 1:1, 1:5, and 1:10 (Target: Effector) ratios. The most effective cell cytotoxicity ratio (1:10) was used in the immunostaining and western blot assays to evaluate apoptosis pathway proteins. The sNK-92 cells showed higher cytotoxic activity on breast cancer cells than NK-92 cells. sNK-92 cells had a selective significant cytotoxicity effect on MCF-7 and SK-BR-3 cells but not MCF-12A cells. While sNK-92 cells were effective at all cell concentrations, they were most effective at a 1:10 ratio. Immunostaining and western blots showed significantly higher BAX, caspase 3, and caspase 9 protein levels in all breast cancer cell groups cocultured with sNK-92 than with NK-92 cells. NK-92 cells stimulated with KIR2DL4 showed elevated cytotoxic activity. The cytotoxic activity of sNK-92 cells on breast cancer cells is via apoptosis pathways. However, their effect on normal breast cells is limited. While the obtained data contains only basic information, additional clinical studies are needed to provide a basis for a new treatment model.
Pediatric Patient-Derived-Xenograft development in MAPPYACTS – international pediatric cancer precision medicine trial in relapsed and refractory tumors
Authors: Costa Maria Eugenia Marques da , Zaidi Sakina , Scoazec Jean-Yves , Droit Robin , Lim Wan Ching , Marchais Antonin , Salmon Jérome , Cherkaoui Sarah , Morscher Raphael , Laurent Anouchka , Malinge Sébastien , Mercher Thomas , Tabone-Eglinger Séverine , Goddard Isabelle , Pflumio Francoise , Calvo Julien , Rédini Françoise , Entz-Werle Natacha , Soriano Aroa , Villanueva Alberto , Cairo Stefano , Chastagner Pascal , Moro Massimo , Owens Cormac , Casanova Michela , Hladun Raquel , Berlanga Pablo , Daudigeos-Dubus Estelle , Dessen Philippe , Zitvogel Laurence , Lacroix Ludovic , Pierron Gaelle , Delattre Olivier , Schleiermacher Gudrun , Surdez Didier , Geoerger Birgit 
Published: February 2023

Abstract
Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient’s tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Paediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This new PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and new treatments development in advanced pediatric malignancies.
Bio-inspired rotary flight of light-driven nanocomposite films
Authors: Wang Dan , Chen Zhaomin , Li Mingtong , Hou Zhen , Zhan Changsong , Zheng Qijun , Wang Dalei , Wang Xin , Cheng Mengjiao , Hu Wenqi , Dong Bin , Shi Feng , Sitti Metin 
Published: February 2023

Abstract
Light-driven photoactuators are promising in a wide range of applications. However, it is still challenging to apply them in flying devices owing to their slow response, small deflection/force and low frequency response. Herein, inspired by the structure of vine maple seeds, we report a nanocomposite film-based soft photoactuator, which exhibits an unprecedented ‘helicopter’-like rotary flight behavior in response to near-infrared (NIR) light (0.6 W/cm2) with ultrafast rotation (~7200 revolutions per minute) and rapid response (~650 ms). This photoactuator is operated based on a fundamentally different mechanism that harnesses the outcome of a series of sequential synergistic interactions between the ternary constituents, i.e., the aerodynamic favorable ‘airscrew’ formation of the hygroscopic agar/silk fibroin film followed by the jet propulsion, which is caused by the photothermal effect of the embedded graphene in the actuator. The soft helicopter-like device exhibits controlled flight and steering behaviors, making it promising for applications in soft robotics, controlled cargo delivery, and other miniature devices.
Detecting thermal anomalies using thermochronometry around hydrothermal veins in the Kii Peninsula, southwest Japan – An attempt
Authors: SUEOKA Shigeru , Iwano Hideki , Danhara Tohru , Niwa Masakazu , Kanno Mizuho , Kohn Barry Paul , Kawamura Makoto , Yokoyama Tatsunori , Kagami Saya , Ogita Yasuhiro , Hirata Takafumi 
Published: February 2023

Abstract
Fluid-inclusion and thermochronometric analyses have been applied to hydrothermal veins and their host rocks outcropping in the Hongu area in the Kii Peninsula, southwestern Japan in an attempt to detect thermal anomalies related to hydrothermal events and to quantify the thermal effects on the host rocks. Hydrothermal events at ~150°C and ~200°C were identified by fluid-inclusion microthermometry of quartz veins. Zircon yielded U–Pb ages of ~74.7–59.2 Ma in the youngest population, fission-track ages of ~27.2–16.6 Ma in the youngest population, and (U–Th)/He single-grain ages of ~23.6–8.7 Ma. Apatite yielded pooled fission-track ages of ~14.9–9.0 Ma. The zircon U–Pb ages constrain the maximum depositional ages of the samples. However, the fission-track and (U–Th)/He dates show no clear trend as a function of distance from the veins. Namely, no thermal anomaly was detected in the surrounding host rocks based on thermochronometry data patterns. The fission-track and (U–Th)/He dates are thought to record the regional thermal and exhumation histories rather than a direct thermal imprint of fluid flow, probably because the duration of such activity was too short or occurred before subsequent regional cooling events when they were thermally overprinted. Apatite fission-track ages of ~10 Ma might reflect regional mountain uplift and exhumation related to rapid subduction of the Philippine Sea slab which was associated with clockwise rotation of the Southwest Japan Arc.