bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis and mapping of scientific literature on virtual and augmented reality technologies used in the context of mental health disorders (1980 – 2021)
Authors: Sweileh Waleed 
Published: May 2023

Purpose
The purpose of this study is to provide a bibliometric analysis of global research publications on virtual and augmented reality (VR/AR) technologies in the understanding, diagnosis and treatment of mental disorders.

Design/methodology/approach
The SciVerse Scopus database was used to retrieve relevant documents using a validated search strategy for the study period from 1980 to 2021.

Findings
In total, 1,233 research articles were found. Research in this field has experienced steep growth since 2017; was disseminated by journals in the fields of clinical psychology, neuroscience, psychiatry and computer sciences; was mainly carried out by scholars in high-income countries with advanced digital technology; has a relatively high number of authors per article but with a relatively poor cross-country research collaboration; was led by researchers and institutions mainly from the USA, Spain and Italy; and has received the highest number of citations for articles on anxiety and phobias.

Research limitations/implications
Bibliometric methodology is a useful tool for identifying evolution growth patterns and research hot topics in the use of emerging technologies in clinical practice. Research on implementing AR/VR technologies in medicine will be enhanced by strengthening international research collaboration. More research attention should be paid to new emerging technologies in the mental health field.

Practical implications
The use of VR/AR technologies became popular as an alternative to or adjunct to traditional therapy in mental health practice. The rapid increase in research publications in recent years suggested that AR and VR technologies were both acceptable and simple to use. A wide range of mental health disorders could be managed by AR/VR technologies. Training medical and nursing students on various new technologies is important to cope with the digital revolution.

Originality/value
Based on the volume and growth patterns of research publications, there is a promising future for the use of VR/AR technologies in the field of mental health. Teaching and training health-care professionals on the proper use of VR/AR are needed to support their potential future use.
Nurse leaders’ experiences of remote leadership in health care
Authors: Hurmekoski Minna , Häggman-Laitila Arja , Lammintakanen Johanna , Terkamo-Moisio Anja 
Published: May 2023

Purpose
This study aimed to describe nurse leaders’ experiences of remote leadership in health care sector.

Design/methodology/approach
Semistructured interviews were conducted among nurse leaders (N = 12) between January and March 2022. All of the interviewees had experiences of remote leadership and worked as immediate – (n = 5) or middle-level (n = 7) leaders in health care organizations across four provinces in Finland. The collected data were analyzed by inductive content analysis.

Findings
The leaders had experienced a rapid transition to remote leadership and highlighted the need for guidelines and joint discussions with different stakeholders. The interviewees felt that working life has changed in the last two years and that remote leadership will now be a key part of leadership in health care. The leaders’ experiences highlighted how important trust is in remote leadership. Furthermore, the interviewees pointed out a need for face-to-face contact and described other good practices for remote leadership. Overseeing work-related well-being was also stressed as important in the remote context; however, the interviewees expressed a need for instructions and tools concerning the management of employee well-being. The sudden change to remote leadership was not only described as interesting but also challenging, which has affected the leaders’ work-related well-being. Support – both from the organization and other employees – was found to be crucial to health care leaders’ work-related well-being.

Originality/value
The current study complements the little-researched topic of remote leadership in the health care sector. The results provide insights that can be used to develop remote leadership and/or guide future research.
How innovation tournaments promote makers' product innovation: economic or social incentives?
Authors: Xiao Ting , Yang Cai , Yang Zhi , Wang Xuan 
Published: May 2023

PurposeResearch on makers and innovation has been equivocal regarding whether maker innovation is driven by internal motivation or external incentives. The motivation view favors the intrinsic motives of makers, whereas the incentive view supports external economic incentives. The authors combine both views to explore how innovation tournaments promote the product innovation outcomes of different creative and entrepreneurial makers, using economic incentives (money) or social incentives (love).Design/methodology/approachThe authors interviewed 42 makers and collected a panel dataset of 29,823 makers from the largest digital maker community in China using a Python crawling program. The authors analyzed the data using multiple methods, including cluster analysis, discriminant analysis, factor analysis and negative binomial regression.FindingsCompared with entrepreneurial makers, the product productivity of creative makers is inferior, but their product popularity is greater. The social incentive of innovation tournaments promotes the product productivity and popularity of creative makers compared with that of entrepreneurial makers, but the economic incentive is contradictory. In addition, social and economic incentives interact to generate inconsistent influences.Originality/valueThe study identifies creative and entrepreneurial makers and contributes to user innovation and innovation tournaments by integrating motivation and incentive views.
Latin American agency: The New Development Bank, Uruguay's accession and Brazilian influence
Authors: Mendez Alvaro 
Published: May 2023

AbstractThis study provides insight into the current evolution of the New Development Bank (NDB). It examines the role of the agency of the global South reshaping intergovernmental organizations (IGOs) in the case of Brazil's influence on the NDB to expand its membership. In that process, this article homes in on the admission of Uruguay to the NDB as a prospective member in September 2021, the first case of NDB expansion into Latin America and the Caribbean (LAC). The study shows that the membership negotiations between Montevideo and the Bank were less rigid and formal than the procedural norms of multilateral development banks (MDBs) of the North, thanks to the collaborative agency by the various LAC actors involved. It makes the case that Uruguay's accession to the NDB will produce numerous win‐win benefits for both the country and the Bank. It also argues that the membership will inspire the future accession of other countries in the LAC region to the Bank. The study adds to the scant literature which conceptualizes the mechanics of membership expansion by small or new IGOs. The piece also adds to existing studies investigating how LAC agency has previously shaped and continues to shape MDBs.
Tumor‐derived exosomal miR‐148b‐3p mediates M2 macrophage polarization via TSC2/mTORC1 to promote breast cancer migration and invasion
Authors: Hao Chong , Sheng Zhimei , Wang Wenhao , Feng Ruijun , Zheng Yuanhang , Xiao Qinpei , Zhang Baogang 
Published: May 2023

AbstractBackgroundEmerging evidence has revealed that tumor‐associated macrophages (TAMs) and exosomes play a crucial role in the microenvironment for tumor growth. However, the mechanisms through which exosomal miRNAs modulate TAMs and tumor development in breast cancer are not fully understood.MethodsWe constructed a macrophage model and an indirect coculture system consist of breast cancer cells and macrophages. Exosomes were isolated from BC cells culture supernatant and identified by transmission electron microscopy, Western blot and Nanosight LM10 system. The expression of miR‐148b‐3p in exosomes was determined by qRT‐PCR and the effect of exosomal miR‐148b‐3p on macrophage polarization was measured using qRT‐PCR and ELISA. The proliferation, migration and invasion of BC cells were estimated by EdU, wound healing assay and transwell assay. We employed bioinformatics, luciferase reporter assay and Western blot to identify the target gene of miR‐148b‐3p. Western blot was used to clarify the mechanism of exosomal miR‐148b‐3p mediated the crosstalk between BC cells and M2 macrophages.ResultsCancer‐derived exosomes could induce M2 polarization of macrophages, which promoted the migration and invasion of breast cancer cells. We found that exosomal miR‐148b‐3p was overexpressed in breast cancer cell‐derived exosomes and correlated with lymph node metastasis, late tumor stage and worse prognosis. Upregulated miR‐148b‐3p expression in exosomes modulated macrophage polarization by targeting TSC2, which promoted the proliferation and might affect migration and invasion of breast cancer cells. Interestingly, we found that exosomal miR‐148b‐3p could induce M2 macrophage polarization via the TSC2/mTORC1 signaling pathway in breast cancer.ConclusionOverall, our study elucidated that miR‐148b‐3p could be transported by exosomes from breast cancer cells to surrounding macrophages and induced M2 polarization by targeting TSC2, providing novel insights for breast cancer therapy.
Male infants are at higher risk of neonatal mortality and severe morbidity
Authors: Wong Cynthia , Schreiber Veronika , Crawford Kylie , Kumar Sailesh 
Published: May 2023

BackgroundWhile a male infant is usually born with a higher birthweight than his female counterpart, he is more at risk of variety of adverse perinatal outcomes. Indeed, throughout life, females exhibit a marked survival advantage compared to males. The aetiology for such pertinent sex disparity remains unclear and is likely multifactorial.AimsThe aim of this study was to investigate obstetric and perinatal outcomes by infant sex from 28 weeks in a contemporary, large Australian birth cohort.Materials and MethodsA 14‐year retrospective cohort study of 130 133 births over 28 weeks gestation from a single tertiary centre.ResultsMale infants had overall higher rates of neonatal mortality (0.12% vs 0.06%, P < 0.001) and severe neonatal morbidity (12% vs 9.1%, P < 0.001) (adjusted odds ratio (aOR) 1.41, 95% CI 1.35–1.47). The odds of overall perinatal mortality (stillbirth and neonatal death) were higher for male infants (aOR 1.30, 95% CI 1.08–1.56). The difference in severe neonatal morbidity when stratified by gestational age at birth only remained significant from >35 weeks gestation. Regardless of infant sex, rates of neonatal mortality and morbidity were lowest at 39 weeks gestation. Rates of preterm birth and operative birth were also higher for male infants.ConclusionsOur study demonstrates significant disparities in clinical outcomes by infant sex with males at a disadvantage to female infants.
Development, validation, and reliability of a measurement scale for investigating the principle of intercooperation
Authors: de Sousa Pedro Henrique Rodrigues , Reyes Junior Edgar , del Corte Lora Víctor 
Published: May 2023

AbstractThe present study aims to develop and validate a measurement scale for investigating the principle of intercooperation, in order to provide researchers in the field of cooperativism with a valid and reliable measure. To this end, four main steps were followed: conceptual mastery, theoretical validation, semantic validation, and statistical validation. First, a preliminary scale was developed based on a literature review and interviews with 20 representatives of cooperatives and representative organizations. Later, the evaluation was carried out by eight academic judges and analyzed using the Content Validity Coefficient. A pre‐test was then carried out with subjects from the population, and subsequently the scale was applied to a sample of 213 cooperatives. Finally, factor analysis was performed with the aim of evaluating convergent and factorial validity as well as individual and construct reliability. Thus, it is proposed that the principle of intercooperation be measured by two different scales. The first, called “Horizontal Intercooperation”, presented a Composite Reliability equal to 0.81 and Average Variance Extracted equal to 0.68. The second, called “Vertical Intercooperation”, presented a Composite Reliability equal to 0.96 and Average Variance Extracted equal to 0.69. After the analyses, the proposed intercooperation scales showed signs of validity and reliability.
Obinutuzumab‐induced acute thrombocytopenia: Report of two cases and review of literature
Authors: Mechelfekh Yaquine , Pontrucher Audrey , Paillassa Jérôme , Temple Marie , Houot Roch 
Published: May 2023

SummaryObinutuzumab (GA101) is a humanized anti‐CD20 monoclonal antibody used in the treatment of B‐cell malignancies. Under rare occasions, obinutuzumab may induce acute and severe thrombocytopenia. However, little is known about this side effect, referred to as “obinutuzumab‐induced acute thrombocytopenia” (OIAT). Here, we report 2 cases of OIAT and review the literature to inform the management and outcome of this rare but life‐threatening complication. The first case is a 74 year‐ old woman who was treated with obinutuzumab‐Cyclophosphamide, Vincristine, Prednisone (CVP) for a previously untreated follicular lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 376 G/L to 3 G/L the day after treatment. The second case is a 44 year‐ old woman who was treated with obinutuzumab as a pre‐treatment dose (day‐8) before glofitamab infusion as a 4th line therapy for mantle cell lymphoma. This patient experienced an acute thrombocytopenia with a drop in her platelet count from 76 G/L (due to splenomegaly and bone marrow involvement) to 3 G/L the day after treatment. OIAT is a rare but life‐threatening complication. Physicians should be aware of this adverse event to optimally detect and treat this complication.
The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms
Authors: Gurney Mark , Chekkaf Ismahene , Baranwal Anmol , Basmaci Rami , Katamesh Bahga , Greipp Patricia , Foran James M. , Badar Talha , Mangaonkar Abhishek A. , Begna Kebede H. , Gangat Naseema , Patnaik Mrinal M. , Litzow Mark R. , Shah Mithun V. , Viswanatha David S. , He Rong , Alkhateeb Hassan B. , Al‐Kali Aref 
Published: May 2023

AbstractETV6 mutations are rare but recurrent somatic events in myeloid neoplasms and are negatively prognostic in myelodysplastic syndrome. We set out to examine the clinical and molecular characteristics of patients undergoing investigation for myeloid neoplasms, found to have deleterious ETV6 mutations. ETV6 mutations occurred in 33 of 5793 (0.6%) cases investigated and predominantly in high‐risk disease entities including MDS with increased blasts, primary myelofibrosis and AML, myelodysplasia‐related. In three cases, isolated iso (17q) karyotype was concurrently detected, an otherwise rare karyotype in myeloid neoplasms. ETV6 mutations were frequently subclonal and never occurred as an isolated abnormality with ASXL1 (n = 22, 75%), SRSF2 (n = 14, 42%) and SETBP1 (n = 11, 33%) the predominant co‐mutations. Restricting to patients with MDS, higher rates of ASXL1, SETBP1, RUNX1 and U2AF1 mutations occurred in ETV6 mutated cases, relative to a consecutive control cohort with wild‐type ETV6. The median OS of the cohort was 17.5 months. This report highlights the clinical and molecular associations of somatic ETV6 mutations in myeloid neoplasms, suggests their occurrence as a later event, and proposes further translational research questions for their role in myeloid neoplasia.
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration
Authors: Qiu Wei , Wang Zhaodan , Chen Zehao , Sun Qian , Wu Hongle , Chen Zhao , Luan Kaiqi , Liu Zining , Ding Dian , Tu Qisheng , Chen Jake , Wu Buling , Fang Fuchun 
Published: May 2023

Background and PurposeLow‐grade inflammation, a common feature of both diabetes and periodontitis, partly accounts for the complexity and refractoriness of diabetes‐associated periodontitis. Adiponectin (APN), the most abundant adipokine in human blood, has been widely reported to have anti‐inflammatory functions. Herein, we investigated the ability of an APN receptor agonist, AdipoAI, to alleviate diabetes‐associated periodontitis. Furthermore, we revealed the possible mechanism underlying its anti‐inflammatory effects.Experimental ApproachThe maxillary first molar of Zucker diabetic fatty (ZDF) rats was ligated to construct a diabetes‐associated periodontitis model, and rats were administered AdipoAI by gavage. We examined diabetes‐related indexes, pathological changes in insulin target organs, alveolar bone resorption and systemic and local inflammation. In vitro, transwell assays were used to evaluate monocyte/macrophage migration induced by human gingival fibroblasts (hGFs) with/without AdipoAI treatment. Additionally, we examined chemokine expression levels in hGFs and hGF‐induced monocyte/macrophage migration upon siRNA knockdown of Adiponectin receptor expression. Expression of Adipo1/Adipo2 receptors and inflammation‐related signalling pathways were examined by IHC and WB, followed by confirmation with an NF‐κB P65 inhibitor (BAY 11‐7082).Key ResultsAdipoAI lowered fasting blood glucose and serum insulin in ZDF rats and alleviated inflammation in insulin target tissues. Locally, AdipoAI reduced alveolar bone absorption and gingival inflammation. Mechanistically, AdipoAI inhibited hGF‐induced monocyte/macrophage migration by reducing CCL2 secretion. In hGFs, AdipoAI attenuated LPS‐induced activation of NF‐κB P65 and CCL2 expression, which was dependent on the Adipo receptor 1.Conclusion and ImplicationsAdipoAI, with its ability to alleviate inflammatory damage in tissues, is a candidate for diabetes‐associated periodontitis treatment.
The multiple roles of media use within the family system during lockdown: A thematic analysis of parental reports from the UK
Authors: Galpin Adam , Bidgood Amy , Taylor Gemma 
Published: May 2023

AbstractChildren's media use increased during the COVID‐19 lockdowns. Here, we present a thematic analysis of online survey responses from 69 parents (of children aged 0–11 years) who described their family media use after the first UK lockdown. Data highlight an increased reliance on media use driven by the challenges of managing time, work, leisure and social connection. Parents reported the additional work of regulating family media use amidst concerns about harmful effects. We draw on an ecological systems approach to discuss how the role of media in family functioning is determined by societal institutions and discourses around parenting and screens.
Downregulation of ciRNA‐Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA‐26a‐dependent manner
Authors: Xie Ling , Zhang Ming , Liu Qiaoqiao , Wei Runa , Sun Menglan , Zhang Qi , Hao Lingyun , Xue Zhouya , Wang Qihui , Yang Li , Wang Hongjun , Pan Zhiqiang 
Published: May 2023

AbstractAimsNerve injury‐induced maladaptive changes in gene expression in the spinal neurons are essential for neuropathic pain genesis. Circular RNAs (ciRNA) are emerging as key regulators of gene expression. Here, we identified a nervous‐system‐tissues‐specific ciRNA‐Kat6 with conservation in humans and mice. We aimed to investigate whether and how spinal dorsal horn ciRNA‐Kat6b participates in neuropathic pain.MethodsUnilateral sciatic nerve chronic constrictive injury (CCI) surgery was used to prepare the neuropathic pain model. The differentially expressed ciRNAs were obtained by RNA‐Sequencing. The identification of nervous‐system‐tissues specificity of ciRNA‐Kat6b and the measurement of ciRNA‐Kat6b and microRNA‐26a (miRNA‐26a) expression level were carried out by quantitative RT‐PCR. The ciRNA‐Kat6b that targets miRNA‐26a and miRNA‐26a that targets Kcnk1 were predicted by bioinformatics analysis and verified by in vitro luciferase reports test and in vivo experiments including Western‐blot, immunofluorescence, and RNA–RNA immunoprecipitation. The correlation between neuropathic pain and ciRNA‐Kat6b, miRNA‐26a, or Kcnk1 was examined by the hypersensitivity response to heat and mechanical stimulus.ResultsPeripheral nerve injury downregulated ciRNA‐Kat6b in the dorsal spinal horn of male mice. Rescuing this downregulation blocked nerve injury‐induced increase of miRNA‐26a, reversed the miRNA‐26a‐triggered decrease of potassium channel Kcnk1, a key neuropathic pain player, in the dorsal horn, and alleviates CCI‐induced pain hypersensitivities. On the contrary, mimicking this downregulation increased the miRNA‐26a level and decreased Kcnk1 in the spinal cord, resulting in neuropathic pain‐like syndrome in naïve mice. Mechanistically, the downregulation of ciRNA‐Kat6b reduced the accounts of miRNA‐26a binding to ciRNA‐Kat6b, and elevated the binding accounts of miRNA‐26a to the 3′ untranslated region of Kcnk1 mRNA and degeneration of Kcnk1 mRNA, triggering in the reduction of KCNK1 protein in the dorsal horn of neuropathic pain mice.ConclusionThe ciRNA‐Kat6b/miRNA‐26a/Kcnk1 pathway in dorsal horn neurons regulates the development and maintenance of neuropathic pain, ciRNA‐Kat6b may be a potential new target for analgesic and treatment strategies.
Super‐high procoagulant activity of gecko thrombin: A gift from sky dragon
Authors: Liang Hao , Zhang Xingyuan , Hou Yuxuan , Zheng Kang , Hao Huifei , He Bingqiang , Li Hui , Sun Chunshuai , Yang Ting , Song Honghua , Cai Rixin , Wang Yingjie , Jiang Haiyan , Qi Lei , Wang Yongjun 
Published: May 2023

AbstractAimsGecko, the “sky dragon” named by Traditional Chinese Medicine, undergoes rapid coagulation and scarless regeneration following tail amputation in the natural ecology, providing a perfect opportunity to develop the efficient and safe drug for blood clotting. Here, gecko thrombin (gthrombin) was recombinantly prepared and comparatively studied on its procoagulant activity.MethodsThe 3D structure of gthrombin was constructed using the homology modeling method of I‐TASSER. The active gthrombin was prepared by the expression of gecko prethrombin‐2 in 293 T cells, followed by purification with Ni2+‐chelating column chromatography prior to activation by snake venom‐derived Ecarin. The enzymatic activities of gthrombin were assayed by hydrolysis of synthetic substrate S‐2238 and the fibrinogen clotting. The vulnerable nerve cells were used to evaluate the toxicity of gthrombin at molecular and cellular levels.ResultsThe active recombinant gthrombin showed super‐high catalytic and fibrinogenolytic efficiency than those of human under different temperatures and pH conditions. In addition, gthrombin made nontoxic effects on the central nerve cells including neurons, contrary to those of mammalian counterparts, which contribute to neuronal damage, astrogliosis, and demyelination.ConclusionsA super‐high activity but safe procoagulant candidate drug was identified from reptiles, which provided a promising perspective for clinical application in rapid blood clotting.