bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical compositions of Litsea umbellata and inhibition activities
Authors: Trung Tu Quang , Hiep Hoang Phu , Van Khang Pham 
Published: March 2023

Abstract

Litsea umbellata (Lour.) Merr. is a plant commonly grown in Vietnam and some Asian countries. The plant is used in traditional medicines and exhibits significant biological activities. However, the sesquiterpenes’ extraction in the essential oil (EO) of L. umbellata harvested from the northern region of Vietnam has been limitedly known. Therefore, in the present study, the L. umbellata leaves and stem EOs were obtained by hydrodistillation method, then determined for the phytochemical profile by using gas chromatography–mass spectrometry system, and investigated the cytotoxicity activities against five cancer cell lines. Results have identified a total of 21 and 26 compounds in the EOs of L. umbellata leaves and stem, respectively, with the main sesquiterpene compounds being β-caryophyllene (16.87–11.04%), (+)-spathulenol (9.74–6.57%), β-caryophyllene oxide (26.12–18.34%), and (−)-spatulenol (11.08–8.8%). L. umbellata leaves exhibit significant anti-cancer activity with IC50 values ranging from 29.58 to 62.96 µg/ml. Otherwise, L. umbellata EOs also exhibited the good inhibition activities against DPPH free radical and three bacteria strains. The chemical constituents and cytotoxicity activity of L. umbellata EO stems have been reported for the first time and provided the future applications of this plant.
A numerical study of water based nanofluids in shell and tube heat exchanger
Authors: Gugulothu Ravi , Sanke Narsimhulu , Somanchi Naga Sarada , Normalla Vikas , Akter Farhana , Sunil Banoth Dhola Ykuntam 
Published: March 2023

Abstract
This numerical investigation is made to estimate the effect of Al2O3 and Cu nanofluids on heat transfer rate, friction factor and thermal performance factor of a shell and tube heat exchanger. Mass flow rates of shell side (water) fluid are varied. Water based nanofluids are used inside the tubes with 0.01, 0.03, and 0.05% volume concentrations of Al2O3 and Cu nanofluids. Nusselt number obtained from the present investigation is compared with Dittus–Bolter equation and Pongjet Pomvonge et al. and found to be in good agreement with a maximum deviation of 3%. The Nusselt number of the dispersed nanofluids increased with the increase of nanofluids volume concentrations and shell side mass flow rate. In this study, maximum enhancement in Nusselt number is 7.50%, 8.65%, and 9.61% for Al2O3, and 1.46%, 2.23%, and 3.18% for Cu nanofluid respectively at 0.01, 0.03, and 0.05% volume concentrations were compared to base fluid as water. Friction factor is highest by 58.00% at 0.05% volume concentration of Cu/H2O nanofluid when relate to Al2O3/H2O nanofluid. Thermal Enhancement factor achieved is highest for Al2O3/H2O nanofluid.
Prioritizing IoT adoption strategies in millennial farming: An analytical network process approach
Authors: Kusnandar Kusnandar , Harisudin Mohamad , Riptanti Erlyna Wida , Khomah Isti , Setyowati Nuning , Qonita Rr. Aulia 
Published: March 2023

Abstract
This research aimed to formulate priority strategies for adopting Internet of Things (IoT)-based innovation by millennial farmers in Central Java Province, Indonesia. This research uses quantitative methods. The two stages involved were exploring external factors using a political, economic, social, and technological approach and internal factors using the resource-based view approach including human resources, physical resources, and organizational resources. Interviews were conducted with 120 millennial farmers in ten regions of Central Java. This led to the formulation of alternative adoption strategies. Furthermore, the second stage was formulating strategic priorities using the analytical network process approach, involving purposively selected experts from policymakers in the government. According to the research, the most considered factors for IoT adoption strategies were relative advantage, social influence, and technology anxiety. In the relative advantage, the most prioritized sub-factor was business profit. The most prioritized technology anxiety sub-factor cluster was unfamiliar with using IoT. The most prioritized social influence sub-factor cluster was a personal relationship. The resulting strategic priorities were strengthening openness to change, IoT education to millennial farmers, optimizing the role of institutions, and socializing the benefits of IoT to millennial farmers. Openness to change motivates millennial farmers to achieve continuous and better innovation. Millennial farmers need to be prepared for the new experiences to come. Government support through education, intensive mentoring, and increasing the active role of farmer mentoring institutions accelerates the adoption of IoT by millennial farmers.
Synthesis of carbohydrate–BODIPY hybrids
Authors: Gomez Ana M. , Ventura Juan , Uriel Clara , Lopez Jose Cristobal 
Published: March 2023

Abstract
Owing to the relevance of fluorescently labeled carbohydrates in the study of biological processes, we have investigated several routes for the preparation of saccharides covalently linked to borondipyrromethene (BODIPY) fluorophores. We have shown that BODIPY dyes can be used as aglycons through synthetic saccharide protocols. In particular, a per-alkylated 8-(2-hydroxy-methylphenyl)-4,4′-dicyano-BODIPY derivative, which withstands glycosylation and protection/deprotection reaction conditions without decomposition, has been used in the stepwise synthesis of two fluorescently labeled trisaccharides. These saccharides displayed high water solubility and a low tendency to (H-)aggregation, a phenomenon that causes loss of photophysical efficiency in BODIPYs. Two additional synthetic strategies toward glyco-BODIPYs have also been described. The first method relies on a Ferrier-type C-glycosylation of the BODIPY core, leading to linker-free carbohydrate–BODIPY hybrids. Secondly, the application of the Nicholas propargylation reaction to 1,3,5,7-tetramethyl BODIPYs provides access to 2,6-dipropargylated BODIPYs that readily undergo CuAAC reactions with azido-containing sugars. From a photophysical standpoint, the BODIPY-labeled saccharides could be used as stable and fluorescent water-soluble chromophores, thereby addressing one of the current challenges in molecular imaging.
Solid-state molecular structures of Se(IV) and Te(IV) dihalides X2Se(CH3)(C6F5) and the gas-phase structure of Se(CH3)(C6F5)
Authors: Glodde Timo , Neumann Beate , Stammler Hans-Georg , Mitzel Norbert W. 
Published: March 2023

Abstract
In a systematic study the Se(IV) and Te(IV) dihalides F2E(CH3)(C6F5), Cl2E(CH3)(C6F5) and Br2E(CH3)(C6F5) (E = Se, Te) have been synthesized and their crystal and molecular structures been investigated by X-ray diffraction and computational methods. The solid-state structures of all compounds show significant correlations between the lengths of the E–C1 bond and the intermolecular E···X (X = F, Cl and Br) contacts, indicating the presence of σ-hole interactions. For comparison, the crystal and gas phase (electron diffraction) structures of Se(CH3)(C6F5) are presented as well. They show very similar structural parameters in both phases. The structures of the single molecules X2E(CH3)(C6F5) have been analyzed by quantum-chemical methods in terms of their surface potentials. They show significant similarities of their molecular electrostatic-potential topologies (V
s,max). The magnitude of V
s,max correlates with the aggregation pattern.
Die Notwendigkeit iterativer Kommunikation in der Fabrikreorganisation
Authors: vom Stein Ninja , Jahangirkhani Tanya , Löwer Manuel , Nyhuis Peter 
Published: March 2023

AbstractZunehmend dynamische Märkte und kürzere Produktlebenszyklen zwingen Unternehmen zu kontinuierlichen Anpassungen ihrer Fabriken in Form von Reorganisationen. Um sicherzustellen, dass solche Reorganisationsprojekte erfolgreich umgesetzt werden können, ist es wichtig, dass das Qualitätsmanagement (QM) frühzeitig in die Fabrikplanung (FAP) integriert wird. In diesem Kontext müssen holistische Qualitätsmanagementsysteme (QMS) agiler und reaktionsfähiger gestaltet werden, um verändernden Anforderungen gerecht zu werden. In diesem Beitrag wird ein Ansatz zur Integration von Qualitätsmanagementsystemen in den Fabrikplanungsprozess nach VDI 5200 vorgestellt. Dazu werden Anforderungen abgeleitet und bestehende Ansätze im Hinblick auf diese bewertet.
Zielorientierte und kontextbasierte Baukostenabschätzung in der frühen Fabrikplanung
Authors: Cevirgen Cihan , Efremov Danil , Kerstgens Jonas , Rieke Leonard , Dersch Sebastian , Nyhuis Peter 
Published: March 2023

Abstract
Für komplexe Fabrikplanungsprojekte, wie z. B. die Neu- oder Erweiterungsplanung, ist in der Regel ein umfangreicher Kapitalbedarf erforderlich, der die finanziellen Unternehmensmittel stark belastet. Für die richtige Beurteilung der Wirtschaftlichkeit eines Fabrikplanungsprojektes ist eine Abschätzung der Baukosten von existenzieller Bedeutung. Oftmals ist unklar, wie die strategischen Ziele sowie kontextbasierten Rahmenbedingungen (z. B. Grundstück oder Fabrikbedarfe) die Baukosten beeinflussen. Dabei ist Letzteres für gewöhnlich ein ausschlaggebendes Auswahlkriterium. Dieser Beitrag stellt ein methodisches Vorgehen vor, mit dessen Hilfe Fabrikziele durch bauliche Maßnahmen konkretisiert und mit den Bedarfen der Fabrik in eine gemeinsame Beschreibungsbasis gebracht werden können. Das Ziel ist die Abschätzung von Baukosten zur Durchführung einer Vorstudie auf Grundlage vordefinierter Baustandards.
Umsetzung der Digitalisierung in der Produktentwicklung
Authors: Gerschütz Benjamin , Goetz Stefan , Wartzack Sandro 
Published: March 2023

Abstract
Die Produktentwicklung befindet sich in einer Transformation. Das etablierte Paradigma der virtuellen Produktentwicklung weicht zunehmend dem Digital Engineering. Insbesondere kleine und mittelständische Unternehmen (KMU) haben jedoch Probleme bei der Optimierung ihrer Prozesse durch Integration datengetriebener Methoden, da Ansätze zur zielgerichteten Prozessanalyse und Methodenidentifikation bislang fehlen. Der vorgestellte Ansatz stellt einen strukturierten Prozess zur Unterstützung der Integration datengetriebener Methoden in der Produktentwicklung zur Verfügung. Der Fokus liegt hierbei darauf, in bestehenden und etablierten Prozessen Anwendungsfälle für neuartige Methoden zu identifizieren und passende Methoden auszuwählen.
Zielgerichtete Gestaltung modularer Maschinen-Architekturen
Authors: Züfle Marc , Christian Berschik Markus , Rennpferdt Christoph , Krause Dieter 
Published: March 2023

Abstract
Für die Optimierung von Wertströmen ist die digitale Fabrik ein guter Lösungsansatz. In die Gestaltung digitaler Fabriken fließen verschiedene Aspekte mit ein – auf Prozess- und auf Produkt-/Systemseite. Letztere erstreckt sich von Bearbeitungszentren bis hin zu fahrerlosen Transportsystemen. Jedes dieser Produkte/Systeme muss eine entsprechende Architektur haben, die die Integration erleichtert. Die Gestaltung der Systemarchitektur sollte daher nicht vernachlässigt werden und ist essenzieller Teil der Entwicklung. Mit der methodischen Entwicklung modularer Architekturen werden Produkte/Systeme bei der Integration in digitale Fabriken unterstützt. In diesem Beitrag wird aufgezeigt, wie der Integrierte PKT-Ansatz zur Entwicklung von modularen Produktfamilien dies ermöglicht.
Digitale Assistenzsysteme strukturiert umsetzen
Authors: Keller Thimo , Stockinger Christopher 
Published: March 2023

Abstract
Digitale Assistenzlösungen ermöglichen – durch eine gezielte Unterstützung der Mitarbeitenden – eine papierlose und effiziente Produktion. So lassen sich Fehler deutlich reduzieren sowie die Produktivität, Flexibilität und Motivation steigern. Die Umsetzung ist jedoch für viele Unternehmen einen Herausforderung. AssistIng hat ein methodisches Vorgehen entwickelt, um die Auswahl und Implementierung Digitaler Assistenzsysteme zielgenau und effizient zu gestalten. Das Vorgehen basiert auf vier Schritten: Potenzialquantifizierung, Prozessanalyse, Systemauswahl und Gestaltung.
Disruptive Veränderungen in der Automobilindustrie bedingen neue Entwicklungsprozesse
Authors: Eigner Martin 
Published: March 2023

Abstract
Dieser Beitrag behandelt die Problemstellung, wie die vorgestellten Trends und Marktveränderungen speziell im Engineering-Prozess umgesetzt werden können. Die Digitalisierung der Produkte, Systeme und die darauf aufbauenden Dienstleistungen sowie Entwicklungsprozesse bedeuten eine Transformation, die die klassischen Grenzen von fragmentierten und konkurrierenden Prozess-, Methoden- und IT-Lösungen neu ordnet: weg vom Silodenken zu einem durchgängigen integrativen und interdisziplinären Lösungsansatz für das Engineering. Themen wie interdisziplinäre Systemarchitektur, Model Based Engineering und System Thinking werden als Vorgehensmodelle vorgestellt.
Two Hippo signaling modules orchestrate liver size and tumorigenesis
Authors: Qi Sixian , Zhong Zhenxing , Zhu Yuwen , Wang Yebin , Ma Mingyue , Wang Yu , Liu Xincheng , Jin Ruxin , Jiao Zhihan , Zhu Rui , Sha Zhao , Dang Kyvan , Liu Ying , Lim Dae‐Sik , Mao Junhao , Zhang Lei , Yu Fa‐Xing 
Published: March 2023

AbstractThe Hippo pathway is a central regulator of organ size and tumorigenesis and is commonly depicted as a kinase cascade, with an increasing number of regulatory and adaptor proteins linked to its regulation over recent years. Here, we propose that two Hippo signaling modules, MST1/2–SAV1–WWC1‐3 (HPO1) and MAP4K1‐7–NF2 (HPO2), together regulate the activity of LATS1/2 kinases and YAP/TAZ transcriptional co‐activators. In mouse livers, the genetic inactivation of either HPO1 or HPO2 module results in partial activation of YAP/TAZ, bile duct hyperplasia, and hepatocellular carcinoma (HCC). On the contrary, inactivation of both HPO1 and HPO2 modules results in full activation of YAP/TAZ, rapid development of intrahepatic cholangiocarcinoma (iCCA), and early lethality. Interestingly, HPO1 has a predominant role in regulating organ size. HPO1 inactivation causes a homogenous YAP/TAZ activation and cell proliferation across the whole liver, resulting in a proportional and rapid increase in liver size. Thus, this study has reconstructed the order of the Hippo signaling network and suggests that LATS1/2 and YAP/TAZ activities are finetuned by HPO1 and HPO2 modules to cause different cell fates, organ size changes, and tumorigenesis trajectories.
Deciding FO-rewritability of Regular Languages and Ontology-Mediated Queries in Linear Temporal Logic
Authors: Kurucz Agi , Ryzhikov Vladislav , Savateev Yury , Zakharyaschev Michael 
Published: March 2023

Our concern is the problem of determining the data complexity of answering an ontology-mediated query (OMQ) formulated in linear temporal logic LTL over (Z,<) and deciding whether it is rewritable to an FO(<)-query, possibly with some extra predicates. First, we observe that, in line with the circuit complexity and FO-definability of regular languages, OMQ answering in AC0, ACC0 and NC1 coincides with FO(<,≡)-rewritability using unary predicates x ≡ 0 (mod n), FO(<,MOD)-rewritability, and FO(RPR)-rewritability using relational primitive recursion, respectively. We prove that, similarly to known PSᴘᴀᴄᴇ-completeness of recognising FO(<)-definability of regular languages, deciding FO(<,≡)- and FO(<,MOD)-definability is also PSᴘᴀᴄᴇ-complete (unless ACC0 = NC1). We then use this result to show that deciding FO(<)-, FO(<,≡)- and FO(<,MOD)-rewritability of LTL OMQs is ExᴘSᴘᴀᴄᴇ-complete, and that these problems become PSᴘᴀᴄᴇ-complete for OMQs with a linear Horn ontology and an atomic query, and also a positive query in the cases of FO(<)- and FO(<,≡)-rewritability. Further, we consider FO(<)-rewritability of OMQs with a binary-clause ontology and identify OMQ classes, for which deciding it is PSᴘᴀᴄᴇ-, Π2p- and coNP-complete.
МЕТАВСЕЛЕННЫЕ КАК НОВЫЙ ОБЪЕКТ РЕГУЛИРОВАНИЯ ДЛЯ ИНФОРМАЦИОННОГО ПРАВА
Authors: ЕВСИКОВ Кирилл Сергеевич 
Published: March 2023

Целью исследования является анализ методов правового регулированию метавселенных. Задачи исследования: выявить правовую природу метавселенной; проанализировать ее архитектурные особенности, способные оказать влияние на правовое регулирование; обобщить зарубежный опыт в данной сфере; изучить отечественное право и судебную практику; выявить возможности создания информационно-правового института метавселенной. В ходе исследования использовались следующие методы: дедукция, индукция, систематизация, юридическое прогнозирование, правовая компаративистика, моделирование.
В ходе исследования автор пришел к следующим результатам. Технология метавселенной пока не получила широкого распространения в Российской Федерации. Однако уже сегодня необходимо искать правовые инструменты защиты граждан от сбора персональных данных владельцами таких информационных систем, а также от противоправного манипулирования ими со стороны владельцев и пользователей метавселенной, включая регламентацию технологий социального инжиниринга. Зарубежный опыт показывает, что метавселенная может стать перспективной сквозной цифровой технологией, для этого органам публичной власти необходимо, избегая «цифрового луддизма», создать нормы права, стимулирующие правомерное поведение владельцев и пользователей данной информационной системы.
Анализ метавселенной позволил утверждать, что пока она является эволюционирующей социальной сетью, и это позволяет распространить на ее владельцев и пользователей нормы права, регулирующие схожие общественные отношения. Анализ судебной практики, проведенный автором, выявил множественные правовые пробелы и юридические коллизии в праве социальных сетей, что пока не позволяет реализовать данное предложение в полной мере. В статье даны конкретные предложения по устранению основных недостатков в существующей правовой системе, а также предложена легальная дефиниция метавселенной. Реализация данных предложений будет способствовать регулированию данной цифровой технологии в нашей стране и становлению нового информационно-правового института — права метавселенной.
Adverse effects of spinal anaesthesia for caesarean section
Authors: Vidya Rani  , Doshi Nilesh Ramanlal , Rajneesh Kumar  , Upadhye Aditi J. , Jayshree J. Upadhye  
Published: March 2023

Background: Obstetric anaesthetists while providing anaesthesia for caesarean sections, provide care for both the mother and the unborn baby. This study was performed to evaluate the adverse effects of spinal anaesthesia for Caesarean section.
Methods: The present study is a prospective observational study carried out on 100 full-term, low risk pregnant patients who had caesarean section under spinal anaesthesia at Varun Arjun medical college, Shahjahanpur, U. P., India from January 2022 to December 2022.
Results: In our study, 43 (43%) patients were between 26-30 years, 32 (32%) patients were between 31-35 years, 16 (16%) patients were between 36-40 years. The 62 (62%) patients were primigravida while 38 (38%) patients were multigravida. The 66 (66%) patients were delivered by emergency caesarean section while 34 (34%) were delivered by emergency caesarean section. In our study, adverse anaesthetic effects were less. 12 (12%) patients had spinal hypotension, 11 (11%) patients had spinal headache, 10 (10%) patients had pruritus, 9 (9%) patients had shivering, 5 (5%) patients had nausea and vomiting, 4 (4%) patients had less visceral pain and neonatal Apgar score each, 3 (3%) patients had failed regional anaesthesia, 3 (3%) patients had bradycardia while 2 (2%) patients had high spinal anaesthesia, 10 (10%) patients had visceral pain.
Conclusions: In our study, combination of bupivacaine and a low dose of fentanyl (0.25 μg/kg) provided excellent surgical anaesthesia with short-lasting postoperative analgesia. There were very few adverse side effects.
Investigation and comparison of depression, anxiety, and stress among hemodialysis and kidney transplant patients during the covid-19 pandemic
Authors: Solaimani Moghaddam Rasool , Baloochi Beydokhti Tahereh 
Published: March 2023

Introduction: Due to the spread of COVID-19, hemodialysis patients experience substantial stress and anxiety regarding post-treatment care after hemodialysis and kidney transplants. This study aims comparison of depression, anxiety, and stress among hemodialysis and kidney transplant patients during the COVID-19 pandemic.
Methods:The statistical population of this descriptive-cross-sectional study included 206 hemodialysis and kidney transplant patients in the special disease center of Birjand city. Eligible patients were selected in a targeted way in 2021 and 2022. The data collection tool included demographic information form and psychological distress questionnaire. SPSS version 20 was used to analyze the collected data using descriptive and inferential statistics. A significance level of less than 0.05 was considered significant
Results:The average scores of depression, anxiety and stress in the kidney transplant group were higher than the hemodialysis group (p<0.001). Depression, anxiety and stress had no significant relationship with the variables of age, income, sex, marriage and place of residence (p>0.05).
Conclusion: The level of depression, anxiety and stress in the kidney transplant group was higher than that of the hemodialysis group, which can be attributed to the concern of the kidney transplant group about rejecting the transplant after contracting the corona virus, and measures are taken to increase the awareness of patients so that they can avoid contracting the disease. prevent illness and future problems
Investigating the Level of Happiness and the Associated Job Factors: A Cross-Sectional Study among Hospital Staff
Authors: Ayaz Nejad Bahare , Mirmohammadkhani Majid , Mansori Kamyar , Pahlevan Daryoush 
Published: March 2023

Introduction: Mental health of the medical staff as care providers has a significant impact on the quality of service delivery. Accordingly, happiness is considered one of the important components of mental health. Considering the importance of mental health for medical staff, especially during COVID19, the present study is designed and carried out with the aim of investigating the level of happiness and associated job factors among hospital staff.
Methods: This was a cross-sectional and analytical study conducted on 280 people from the teaching, research and treatment staff of Kowsar hospital in Semnan through census in 2019. To collect data, a checklist including demographic and occupational variables was used along with Oxford Happiness Questionnaire by Hills and Argyle (2002). After that, relevant data were analyzed through SPSS26 software.
Results: The mean and standard deviation regarding age of the personnel were 53.53 ± 8.09, 62.1% of whom were women. 47.5% were in low status, and only 10% were in high status in terms of happiness score distribution. People in the age group of 51 to 60 (P >0.001), PhD graduates (P<0.001), working doctors (P<0.001), official workers (P=0.008), personnel with fixed work shifts (P <0.001), personnel who do not need to work overtime (P =0.044), people with good interaction with colleagues (P <0.001), and employees with good job satisfaction (P<0.001), had a good or excellent happiness status.
Conclusion: Most of the medical personnel working in the hospital did not have an optimal level of happiness; therefore, it is recommended that authorities design and implement programs to improve the level of happiness by focusing on the related factors.