bluuebunny/crossref_metadata_2025_split huggingface dataset:
The P3 indexes the distance between perceived and target image
Authors: de la Torre‐Ortiz Carlos , Spapé Michiel , Ruotsalo Tuukka 
Published: March 2023

AbstractVisual recognition requires inferring the similarity between a perceived object and a mental target. However, a measure of similarity is difficult to determine when it comes to complex stimuli such as faces. Indeed, people may notice someone “looks like” a familiar face, but find it hard to describe on the basis of what features such a comparison is based. Previous work shows that the number of similar visual elements between a face pictogram and a memorized target correlates with the P300 amplitude in the visual evoked potential. Here, we redefine similarity as the distance inferred from a latent space learned using a state‐of‐the‐art generative adversarial neural network (GAN). A rapid serial visual presentation experiment was conducted with oddball images generated at varying distances from the target to determine how P300 amplitude related to GAN‐derived distances. The results showed that distance‐to‐target was monotonically related to the P300, showing perceptual identification was associated with smooth, drifting image similarity. Furthermore, regression modeling indicated that while the P3a and P3b sub‐components had distinct responses in location, time, and amplitude, they were similarly related to target distance. The work demonstrates that the P300 indexes the distance between perceived and target image in smooth, natural, and complex visual stimuli and shows that GANs present a novel modeling methodology for studying the relationships between stimuli, perception, and recognition.
Phylogeny of the flea beetles (Galerucinae: Alticini) and the position ofAulacothoraxelucidated through anchored phylogenomics (Coleoptera: Chrysomelidae: Alticini)
Authors: Douglas Hume B. , Konstantinov Alexander S. , Brunke Adam J. , Moseyko Alexey G. , Chapados Julie T. , Eyres Jackson , Richter Robin , Savard Karine , Sears Elizabeth , Prathapan Kaniyarikkal D. , Ruan Yongying , Dettman Jeremy R. 
Published: March 2023

AbstractThe Alticini comprise 601 genera and 10,000 species, including plant pests. Their phylogeny remains largely unresolved, inhibiting taxonomic stability, specimen identification and biological understanding. Here, we generated a genomic dataset using Anchored Hybrid Enrichment (AHE) for 54 genera of Alticini, 16 of Galerucini, and 40 of other Chrysomelidae to test the monophyly of Alticini, and its genus groups, and to examine the utility of established diagnostic characters. Maximum likelihood and coalescent phylogenetic analyses produced resolved and overall congruent topologies. Synetinae was sister to Cassidinae + Eumolpinae + Lamprosomatinae + Cryptocephalinae, supporting its recognition as valid. Within Galerucinae,AulacothoraxBoheman was found as sister to Galerucini + Alticini (each monophyletic). Tribe Serraticollini Whitestat. rev.is reinstated as valid, as the oldest available name for the higher lineage containingAulacothorax. We extend Crowson's classification, with Alticini, Galerucini, and Serraticollini united under Galerucinae. We transfer generaChalaenosomaJacoby,DemarchusJacoby, andMandarellaDuvivier from Alticini to Galeruciniincertae sedis, and confirm prior transfers ofHesperaWeise,LuperomorphaWeise andNonarthraBaly from Alticini to Galeruciniincertae sedis. Galerucini and Alticini are reciprocally monophyletic following these transfers. Our work recovered multiple evolutionary origins of jumping hind legs in Galerucinae, hindering straightforward morphological diagnosis of tribes. We provide diagnoses for Alticini, Galerucini and Galerucinae, but these require dissection of female genitalia. We achieved some phylogenetic resolution within Alticini, but found few adult morphological characters to define subclades. Our results indicate that with future denser taxon sampling, AHE phylogenomics could provide a robust basis for subtribal classifications.
Experimental Analysis of a Bayonet Tube at Constant Wall Temperature Conditions Under Laminar, Transition, and Turbulent Flow
Authors: Singh Nishant , Sharma Ram Vinoy , Kumar Shalendra 
Published: March 2023

Abstract
An experiment was carried out on a bayonet tube that was kept at a constant temperature using condensing steam. In contrast, cold water was permitted to enter the central tube and discharge via an annular portion. The water flow rate was varied, covering laminar, transition, and turbulent regimes. The inner part of the bayonet tube is CPVC (chlorinated polyvinyl chloride, k = 0.136 W · m−1 · K−1), which reduces short-circuit heat transfer across the tube. Temperatures were recorded at different points in the tube. From the results of experiments on total heat transfer and short-circuit heat transfer, the Nusselt number can be calculated. The pressure drop across a bayonet tube determined the friction factor. In examining a range of Reynolds numbers, Effectiveness and figure of merit have been resolved. It has been observed that as the Reynolds number increases, the Nusselt number increases while the friction factor decreases. Both Effectiveness and Figure of Merit decrease with the addition of the Reynolds number, and it is observed that the maximum effective value is 0.86 for a 75 Reynolds number, which is suitable for bayonet solar collectors, and the minimum effective value is 0.2 for an 8062 Reynolds number, which is suitable for bayonet heat exchangers. It serves as reference work for bayonet tubes for designing a parabolic solar collector and heat exchanger.
Electro-Chemo-Mechanical Challenges and Perspective in Lithium Metal Batteries
Authors: Naik Kaustubh G. , Vishnugopi Bairav S. , Datta Joy , Datta Dibakar , Mukherjee Partha P. 
Published: March 2023

Abstract
The development of next-generation batteries, utilizing electrodes with high capacities and power densities requires a comprehensive understanding and precise control of material interfaces and architectures. Electro-chemo-mechanics plays an integral role in the morphological evolution and stability of such complex interfaces. Volume changes in electrode materials and the chemical interactions of electrode/electrolyte interfaces result in nonuniform stress fields and structurally different interphases, fundamentally affecting the underlying transport and reaction kinetics. The origin of this mechanistic coupling and its implications on degradation is uniquely dependent on the interface characteristics. In this review, the distinct nature of chemo–mechanical coupling and failure mechanisms at solid–liquid interfaces and solid–solid interfaces is analyzed. For lithium metal electrodes, the critical role of surface/microstructural heterogeneities on the solid electrolyte interphase (SEI) stability and dendrite growth in liquid electrolytes, and on the onset of contact loss and filament penetration with solid electrolytes is summarized. With respect to composite electrodes, key differences in the microstructure-coupled electro-chemo-mechanical attributes of intercalation- and conversion-based chemistries are delineated. Moving from liquid to solid electrolytes in such cathodes, we highlight the significant impact of solid–solid point contacts on transport/mechanical response, electrochemical performance, and failure modes such as particle cracking and delamination. Finally, we present our perspective on future research directions and opportunities to address the underlying electro-chemo-mechanical challenges for enabling next-generation lithium metal batteries.
A Self-Reflective Toolkit of Adult-Oriented Coaching Practices in Masters Sport
Authors: Callary Bettina , Belalcazar Catalina , Rathwell Scott , Young Bradley W. 
Published: March 2023

The Adult-Oriented Sport Coaching Survey (AOSCS) assesses psychosocial coaching practices for coaches who work with adult athletes. The AOSCS can be used as a self-assessment tool for coaches’ professional development, but there is a need to better understand its relevance for coaches. The purpose of this study was to explore coaches’ perspectives of the AOSCS as a self-assessment tool for reflecting, intuitively appraising, and provoking elaborations on contextually embedded psychosocial practices when coaching adult athletes. Thirteen Canadian coaches (nine women/four men, aged 59–78 years) completed the AOSCS prior to watching a webinar regarding the research on coaching Masters athletes and the development of the AOSCS. Each was subsequently shared a copy of their AOSCS results and interviewed about their perceptions of the relevance and utility of the AOSCS. Interviews were analyzed using reflexive thematic analysis, which resulted in three higher order themes (relevance of the AOSCS, using the AOSCS, and input from others) with six subthemes. The coaches see the AOSCS as provoking meaningful coach reflection, introspection, and learning intrapersonal coaching knowledge that serve ongoing coach development. As such, this paper outlines evidence with respect to the prospective relevance and practical utility of the AOSCS.
Patterns of Platelet Mapping Thromboelastography Abnormalities in Trauma
Authors: Quinn Seth A. , Gregg Stephen E. , Garcia Nicole , Fu Yuanyuan , Irish William , Toschlog Eric A. 
Published: March 2023

Objectives Platelet mapping thromboelastography (TEG-PM) to evaluate trauma induced coagulopathy has become more prevalent. The objective of this study was to evaluate associations between TEG-PM and outcomes in trauma patients, including patients with TBI. Methods A retrospective review was conducted utilizing the American College of Surgeons National Trauma Database. Chart review was conducted to obtain specific TEG-PM parameters. Patients were excluded if they were on anti-platelets, anticoagulation, or received blood products prior to arrival. TEG-PM values and their associations with outcomes were evaluated using generalized linear model and Cox cause-specific hazards model. Outcomes included in-hospital death, hospital and ICU length of stay (LOS). Relative risk (RR) and hazard ratio (HR) and their 95% confidence intervals (CIs) are provided. Results A total of 1066 patients were included, with 151 (14%) diagnosed with isolated TBI. ADP inhibition was associated with significant increase rate of hospital LOS and ICU LOS (RR per % increase = 1.002 and RR = 1.006 per % increase, respectively) while increased MA(AA) and MA(ADP) were significantly associated with decrease rate of hospital LOS and ICU LOS (RR = .993 per mm increase and RR = .989 per mm increase, respectively, and RR = .986 per mm increase and RR = .989 per mm increase). R (per minute increase) and LY30 (per % increase) were associated with increased risk of in-hospital mortality (HR = 1.567 and HR = 1.057, respectively). No TEG-PM values significantly correlated with ISS. Conclusion Specific TEG-PM abnormalities are associated with worse outcomes in trauma patients, including TBI patients. These results require further investigation to understand associations between traumatic injury and coagulopathy.
The American Association for the Surgery of Trauma Organ Injury Scale is Associated With Cystoscopic and Percutaneous Urologic Procedures in Renal Injuries
Authors: Brigode William , Roberts Drew , Capron Gweniviere , Starr Frederic , Bokhari Faran 
Published: March 2023

Background The American Association for the Surgery of Trauma Organ Injury Scale for the kidney was created in 1989. It has been validated to various outcomes including operations. It was updated in 2018 to better predict endourologic interventions, but this change has not been validated. In addition, the AAST-OIS does not consider mechanism of trauma in its interpretation. Methods We analyzed 3 years of the Trauma Quality Improvement Program database including all patients with a kidney injury. We recorded rates of mortality, operation, renal operation, nephrectomy, renal embolization, cystoscopic intervention, and percutaneous urologic procedures. Results 26294 patients were included. In penetrating trauma, mortality, operation, renal-specific operation, and nephrectomy rates increased at every grade. Renal embolization and cystoscopy rates peaked in grade IV. Percutaneous interventions were rare across all grades. In blunt trauma, mortality and nephrectomy rates increased only in grades IV and V. Operation, renal operation, and renal embolization rates increased at every grade level. Cystoscopy rates peaked in grade IV. Percutaneous procedure rates only increased between grades III and IV. Penetrating injuries are more likely to require nephrectomy in grades III-V, cystoscopic procedures in grade III, and percutaneous procedures in grades I-III. Discussion Endourologic procedures are most utilized in grade IV injuries, which are in part defined by injuries with damage to the central collecting system. Despite penetrating injuries more frequently requiring nephrectomy, they also more frequently require nonsurgical procedures. Mechanism of trauma should be considered when interpreting the AAST-OIS for kidney injuries.
Stability assessment of serum tumour markers: Calcitonin, chromogranin A, thyroglobulin and anti-thyroglobulin antibodies
Authors: Thirkettle Sally , Blaszczyk Patrycja , Evans Rachel , Wheatley Michael , Abbas Madihah , Russell Joanne , Monaghan Phillip J 
Published: March 2023

Background There is limited published data on the stability of calcitonin, chromogranin A, thyroglobulin and anti-thyroglobulin antibodies in serum. The aim of this study was to determine stability at three temperature conditions over 7 days, reflecting current laboratory practices. Methods Surplus serum was stored at room temperature, refrigerated and in the freezer; for 1, 3, 5 and 7 days. Samples were analysed in batch and analyte concentrations compared to that of a baseline sample. Measurement Uncertainty of the assay was used to determine the Maximal Permissible Difference and thus the stability of the analyte. Results Calcitonin was found to be stable for at least 7 days in the freezer but only 24 h refrigerated. Chromogranin A was stable for 3 days when refrigerated and only 24 h at room temperature. Thyroglobulin and anti-thyroglobulin antibodies were stable under all conditions for 7 days. Conclusion This study has enabled the laboratory to increase the add-on time limit of Chromogranin A to 3 days, and up to 60 min for calcitonin and inform optimal storage and transportation conditions for referring specimens.
Cross-Cultural Adaptation of the Condition-Specific Malocclusion Impact Questionnaire for the Malayalam-speaking Population—A Psychometric Scale Validation Study
Authors: J. Monisha , Peter Elbe , R.M. Baiju , Benson Philip Edward , George Suja Ani 
Published: March 2023

Objectives The study aimed to develop a regional version of the Malocclusion Impact Questionnaire (MIQ-Malayalam) for the Malayalam-speaking Indian population. Methods The English version of MIQ was translated into Malayalam through a rigorous translation process, followed by cross-cultural adaptation. Young people aged below 18 years who were just about to start orthodontic treatment were invited to complete the Malayalam version of MIQ along with the available native version of the Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ). The MIQ-Malayalam was readministered after 14 days to assess test-retest reliability. Treatment need was assessed normatively using the Dental Health Component of the Index of Orthodontic Treatment Need (IOTN-DHC) and subjectively using Aesthetic Component of the Index of Orthodontic Treatment Need (IOTN-AC). Results A total of 210 subjects completed the questionnaires (males = 47.2%; females = 52.8%; age = 12-17 years, mean = 15 years and 3 months; standard deviation = 1.9) and 50 completed repeat questionnaires. Internal consistency and test-retest reliability were high (Cronbach’s alpha = 0.952; Intra-class Correlation Coefficient = 0.93). Exploratory factor analysis derived 4 factors with exclusion of 1 item. There were significant differences ( P < .05) in MIQ scores between IOTN-DHC subgroups, ensuring discriminant validity. There was a high correlation between total MIQ and total PIDAQ scores (rho = 0.884), while low between total MIQ and IOTN-AC scores (rho = 0.203). Conclusion The Malayalam version of MIQ was found to be valid and reliable and can serve as a useful condition-specific measure of oral health-related quality of life.
The impact of curcumin supplementation on systemic lupus erythematosus and lupus nephritis: A systematic review
Authors: Ramessar Nina , Borad Abhilasha , Schlesinger Naomi 
Published: March 2023

Objective Curcumin is the active ingredient in the curry spice turmeric. It has anti-inflammatory properties due to the inhibition of transcription factors and inflammatory mediators such as nuclear factor- κβ (NF- κβ), cyclooxygenase-2 (COX2), lipoxygenase (LOX), tumor necrosis factoralpha (TNF-alpha), and interleukin-1 (IL-1) and 6 (IL-6). This review examines the literature regarding the efficacy of curcumin on systemic lupus erythematosus disease activity. Methods A search was conducted following guidelines in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) using the PubMed, Google Scholar, Scopus, and MEDLINE electronic databases to retrieve relevant studies assessing the impact of curcumin supplementation on SLE. Results The initial search yielded three double-blind, placebo-controlled, randomized clinical trials, three human in vitro studies, and seven mouse-model studies. In human trials, curcumin decreased 24-h and spot proteinuria, but the trials were small, ranging from 14 to 39 patients, with varied curcumin doses and different study durations ranging from 4 to 12 weeks. There was no change in C3, dsDNA, or the Systemic Lupus Erythematosus Disease Activity (SLEDAI) scores even in the longer trials. The mouse-model trials yielded more data. NF- κβ activation was suppressed along with inducible nitric oxide synthase (NOS) species expression when 1 mg/kg/day of curcumin was administered for 14 weeks, leading to significant decreases in dsDNA, proteinuria, renal inflammation, and IgG subclasses. Another study suggested that curcumin reduced B cell-activating factor (BAFF) when used for up to 8 weeks at 50 mg/kg/day. A reduction in pro-inflammatory Th1 and Th17 percentages, IL-6 and anti-nuclear antibody (ANA) levels were reported. The doses used in the murine models were much higher than those used in human trials, with 12.5 mg–200 mg/kg/day used for over 16 weeks; highlighting that the optimal time for an immunological effect to be observed may require 12–16 weeks of curcumin use. Conclusion Despite the wide use of curcumin in everyday life, its molecular and anti-inflammatory use has only been partially explored. Current data show a potential benefit on disease activity. Still, no uniform dose can be advised because long-duration, large-scale randomized trials using defined dosing are needed in different subsets of SLE, including lupus nephritis patients.
Ending the doctor–patient relationship
Authors: Lehman Kirk , Edirisinghe Vinuri 
Published: March 2023

Objective Terminating a therapeutic relationship can be particularly challenging and onerous for the treating medical practitioner. There are multiple reasons why a practitioner may desire to terminate the relationship, ranging from inappropriate behaviour and assault through to threatened or actual litigation. This paper provides psychiatrists as well as all doctors and support staff who work alongside them with a simple, step-by-step visual guide to terminating a therapeutic relationship, giving due consideration to their professional and legal obligations in line with common recommendations by medical indemnity organisations. Conclusions If a practitioner’s ability to manage the patient is inadequate or compromised due to an emotional, financial, or legal circumstance, it is reasonable to consider termination of the relationship. Practical steps such as taking contemporaneous notes, writing to the patient and their primary care doctor, ensuring continuity of healthcare, and communicating with authorities where appropriate have been identified as components commonly recommended by medical indemnity insurance organisations.
Cytokine receptor IL27RA is an NF-κB–responsive gene involved in CD38 upregulation in multiple myeloma
Authors: Brownlie Rebecca J. , Kennedy Ruth , Wilson Erica B. , Milanovic Maja , Taylor Claire F. , Wang Dapeng , Davies John R. , Owston Heather , Adams Emma J. , Stephenson Sophie , Caeser Rebecca , Gewurz Benjamin E. , Giannoudis Peter V. , Scuoppo Claudio , McGonagle Dennis , Hodson Daniel J. , Tooze Reuben M. , Doody Gina M. , Cook Gordon , Westhead David R. , Klein Ulf 
Published: March 2023

Abstract
Multiple myeloma (MM) shows constitutive activation of canonical and noncanonical nuclear factor κB (NF-κB) signaling via genetic mutations or tumor microenvironment (TME) stimulations. A subset of MM cell lines showed dependency for cell growth and survival on the canonical NF-κB transcription factor RELA alone, suggesting a critical role for a RELA-mediated biological program in MM pathogenesis. Here, we determined the RELA-dependent transcriptional program in MM cell lines and found the expression of the cell surface molecules interleukin-27 receptor-α (IL-27Rα) and the adhesion molecule JAM2 to be responsive to RELA at the messenger RNA and protein levels. IL-27Rα and JAM2 were expressed on primary MM cells at higher levels than on healthy long-lived plasma cells (PCs) in the bone marrow. IL-27 activated STAT1, and to a lesser extent STAT3, in MM cell lines and in PCs generated from memory B cells in an IL-21–dependent in vitro PC differentiation assay. Concomitant activity of IL-21 and IL-27 enhanced differentiation into PCs and increased the cell-surface expression of the known STAT target gene CD38. In accordance, a subset of MM cell lines and primary MM cells cultured with IL-27 upregulated CD38 cell-surface expression, a finding with potential implications for enhancing the efficacy of CD38-directed monoclonal antibody therapies by increasing CD38 expression on tumor cells. The elevated expression of IL-27Rα and JAM2 on MM cells compared with that on healthy PCs may be exploited for the development of targeted therapeutic strategies that modulate the interaction of MM cells with the TME.