bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate Change and Heat Stress Resilient Outdoor Workers: Findings from Systematic Literature Review
Authors: Habibi Peymaneh , Razmjouei Jaleh , Moradi Amirhossein , Mahdavi Farank , Falla-Aliabadi Saeed , Heydari Ahad 
Published: September 2023

Abstract
Purpose: Global warming has led to an increase in the number and intensity of extreme heat events, posing a significant threat to the health and safety of workers, especially those working outdoors, as they often have limited access to cooling strategies. This systematic literature review aims to compile strategies to enhance occupational heat stress resilience among outdoor workers in the context of climate change.
Materials and Methods: In this systematic review, we searched scientific databases including Scopus, Web of Science, and PubMed. Additionally, we identified relevant studies on climate change and heat-stress control measures through Google Scholar using specific search terms. In total, we monitored 2001 articles pertaining to worker populations (men=2921; women=627) in various outdoor climate conditions across 14 countries.
Results. Global warming significantly contributes to the rise in occupational heat stress. Failure to implement effective control strategies for outdoor workers will result in decreased resilience to thermal stress. The findings underscore a lack of awareness regarding certain adaptation strategies and interventions aimed at preventing and enhancing resilience to the impact of climate change on heat stress prevalence among workers in outdoor tropical and subtropical environments.
Conclusion. The integration of climate change adaptation strategies into occupational health programs can enhance occupational heat resilience among outdoor workers. Conducting cost-benefit evaluations of health and safety measures for thermal stress adaptation strategies among outdoor workers is crucial for professionals and policymakers in low- and middle-income tropical and subtropical countries. Projected future global warming conditions will dangerously affect the anticipated occupational heat stress resilience of outdoor workers worldwide. Risk management strategies, adaptive measures, heat risk awareness, practical interventions, training programs, and protective policies should be implemented in hot-dry and hot-humid climates to boost the tolerance and resilience of outdoor workers.
Cucurbitacin E reduce IL-1β-induced inflammation and cartilage degeneration in osteoarthritic chondrocytes by inhibiting the PI3K/AKT pathway
Authors: Wang Lin , Xu Hui , Zhu Xunpeng , Zhang haigang , Chen hongwei , Lin Zhijie , Guo Shilei , Bao Zhibo , Rui Haicheng , Zhang Hui 
Published: September 2023

Abstract
Osteoarthritis (OA) is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change of osteoarthritis. It is generally considered to be a low-grade inflammatory disease, and persistent inflammation is one of the driving factors of cartilage degeneration. Cucurbitacin E (CuE) is a compound isolated from cucurchinaceae that has been shown to have anti-inflammatory effects, but its role and mechanism in osteoarthritis chondrocytes are unknown. In this study,We demonstrated that CuE effectively inhibited the protein expression of IL-1β and COX-2 produced by IL-1β-induced inflammatory cytokines in chondrocytes, and then clarified the mechanism of CuE action on osteoarthritis chondrocytes by evaluating the effect of CuE on chondrocytes in vivo and in vitro, and based on the PI3K/ akt signaling pathway. The results showed that CuE alleviated the loss of collagen in OA chondrocytes induced by IL-1β in vitro, and reduced the expression level of matrix degrading protease such as MMP13 stimulated by IL-1β, which showed that CuE had a certain protective effect on the knee cartilage of mouse in the DMM(destabilization of the medial meniscus) osteoarthritis model established in C57BL/6 mouse. In addition, by mining the GSE114007 and GSE117999 databases, we found that the PI3K/AKT pathway is highly clustered in osteoarthritis, and immunohistochemical analysis of the human cartilage pathological tissue slices we extracted showed that the expression of p-PI3K in patients with osteoarthritis was higher than that in the normal group. The cell thermal stability experiment showed that CuE could effectively bind to PI3K molecule. Molecular docking analysis showed that CuE had a strong binding affinity with the inhibition target of PI3K. Western blot analysis demonstrated that CuE inhibited the protein expression of PI3K/AKT pathway in chondrocytes. These results suggest that CuE can inhibit PI3K/AKT pathway by inhibiting IL-1β-induced PI3K activation in OA chondrocytes, thereby alleviating OA progression. In summary, we suggest that CuE may be a potential therapeutic agent for OA by inhibiting the PI3K/AKT pathway.
The analysis of daily dynamics of geomagnetic field variations spectrum under quiet and disturbed conditions
Authors: Mukasheva Saule , Andreyev Alexey , Sokolova Olga , Kapytin Vitaliy 
Published: September 2023

Abstract
The results of static analysis of measurement records of three components of the Earth's magnetic field obtained at the Alma-Ata Observatory [43.25°N; 76.95°E] are presented. The daily dynamics of the spectrum of measurements of the parameters of the geomagnetic field obtained by adding the spectra of magnetically quiet days with a maximum daily Ap index of less than 5 for the period from 2010 to 2018 was considered. Regular fluctuations in the range of acoustic-gravity waves are revealed. The power spectrum of measurement records of three magnetic field components during a geomagnetic storm (Kp = 8) and under quiet geomagnetic conditions (Kp = 2) was also studied.
Prediction Method for Aging Life of Rubber O-Rings Based on GRU-LSTM Neural Network
Authors: Zheng Rao , Liu Lijing , Li Shuangxi , Li Ye , Qi Zhicheng 
Published: September 2023

Abstract
This paper proposes a prediction model for rubber aging life based on the GRU-LSTM neural network to address the issue of sealing failure caused by material aging of rubber O-rings in the petrochemical industry. The model aims to overcome the limits of existing methods, which have low prediction accuracy and poor stability. In this study, we conducted rubber aging experiments to get data on rubber compression set at different temperatures. After preprocessing the data, we experimentally verified and compared the GRU-LSTM model with the two-layer LSTM model, two-layer GRU model, and BP neural network. Finally, we carried out an example analysis and application of high-temperature flange sealing in a chemical equipment. The results revealed significant differences between the two types of rubber, NBR-26 and HNBR. When using the aging data at 60, 80, and 100°C to predict the aging data at 70 and 90°C, the R2 values for NBR-26 and HNBR were 0.9968 and 0.9945, respectively. These findings highlight the superior predictive performance of the proposed model. These results show significantly better prediction performance compared to the other three models. Further, the accuracy of the prediction results increased with the number of temperature levels and samples. We recommend using at least three temperatures for prediction, and a larger sample size is preferable. The example analysis showed that this prediction model can help decide the replacement cycle of high-temperature flange rubber O-rings at different storage temperatures, reducing maintenance costs.
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation
Authors: Zhang Lijuan , Ma Jian , Yang Mingfei , Zhao Tianming , Han Meiyan , Zheng Dege , Mapook Ausana , Lu Yongzhong , Jayawardena Ruvishika S 
Published: September 2023

Abstract
A chemical investigation of the rice fermentation by the saprophytic fungus Neohelicosporium griseum, isolated from decayed wood, yielded vertixanthone (1), diaportheone A (2), 1,3,6,8-tetrahydroxyanthraquinone (3), lecanoric acid (4), decarboxycitrinone (5), 6,8-dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (6), decarboxyhydroxycitrinone (7), and ergosterin (8). The 1D and 2D NMR character of compound 1 in DMSO-d6 was described in detail for the first time. An investigation of the antimicrobial activities of the isolated compounds revealed moderate activity of compounds 1–4 against Pseudomonas aeruginosa, and weak activity of compound 3 against Staphylococcus aureus. An in-vitro cytotoxic test showed that compounds 1, 3, and 4 had cytotoxic activity against HELA cell lines, with respective IC50 values of 30.8, 13.7, and 14.1 µM. Compounds 1, 3, and 4 also showed significant cytotoxicity against A549 cell lines, with respective IC50 values of 24.7, 7.4, and 10.3 µM.
A metrical method of sex estimation for two medieval scottish populations
Authors: Bissonnette Danielle 
Published: September 2023

Abstract

Calcanei and tali are robust, sexually dimorphic, weight-bearing foot-bones that survive well in forensic and archaeological contexts. In this study, sex estimations were conducted on calcanei and tali from the Ballumbie and St. Andrews Library mediaeval Scottish populations provided by the University of Edinburgh, Scotland, applying the Alonso-Llamazares and Pablos (2019) method. This method has proven accuracy of up to 96.4% for the Hamann-Todd Human Osteological collection, 91.4% for Homo sapiens from data published by other authors and 100.0% for both the Sima de los Huesos hominids and Homo neanderthalensis, based on discriminant functions for the calcaneus and talus. In this study, 39 calcanei from 19 males and 20 females and 56 tali from 25 males and 31 females were used. The functions obtained produced accuracies varying from 67.3% − 88.4% for univariate and from 79.1% − 100.0% for the multivariate discriminant formulae. This study confirms the finding of Alonso-Llamazares and Pablos (2019) that multivariate statistical analysis of the calcaneus and talus combined generally produce more accurate sex estimations than univariate statistical methods. Measurements yielding the highest accuracy for sex estimation were the maximum length of the calcaneus, posterior talar articular surface length of the calcaneus, talar length and total length of the talus. The Alonso-Llamazares and Pablos (2019) formulae applied to these two mediaeval populations produced accuracies ranging from 43.9% − 89.4% for univariate and from 75.6% − 97.1% accuracy for multivariate formulae. The best predictor for sex from both studies was the total talar length (M1a).
Enhancing Ontology Integration in Medical Texts through Advanced Mechanisms
Authors: Kawas Mouhamad , Alkhatib Bassel , Dashash Mayssoon 
Published: September 2023

Abstract
Ontology integration involves combining several data sources into a single and unified knowledge representation. In the context of medical texts, ontology integration plays a crucial role, as these texts include essential knowledge for clinical and research applications. However, existing methods for incorporating ontologies into medical texts have exhibited limitations in terms of comprehensiveness, flexibility, semantic accuracy, logical rigor, efficiency, and overall effectiveness. To address these shortcomings, this paper introduces an enhanced ontology integration mechanism tailored specifically for medical texts. Our proposed mechanism integrates various data sources within medical texts seamlessly by employing a combination of ontological, logical, lexical, structural, semantic, declarative, and machine-learning techniques. This mechanism leverages a common upper ontology and a set of transformation rules to align concepts and relationships across different source ontologies. Additionally, it utilizes a supervised machine learning approach to predict mappings between concepts and relationships originating from various source ontologies. To assess the effectiveness of our mechanism, extensive evaluations using diverse datasets, ontologies, and benchmark tests for ontology matching, evaluation, text processing, and application were undertaken. Through rigorous comparisons with existing approaches, the superior performance and effectiveness of our mechanism were demonstrated. In addition, a comprehensive analysis of its strengths, weaknesses, and implications for both research and real-world implementation within the field of medicine was also performed. This mechanism represents a significant advancement in ontology integration for medical texts, empowering data-driven decision-making in the field of medicine.
Performance comparison of Gilbert's algorithm and machine learning in classifying Bell-diagonal two-qutrit entanglement
Authors: Wieśniak Marcin 
Published: September 2023

Abstract
While classifying states as entangled or separable is one of the fundamental tasks in quantum information theory, it is also extremely challenging. This task is highly nontrivial even for relatively simple cases, such as two-qutrit Bell-diagonal states, i.e., mixtures of nine mutually orthogonal maximally entangled states. In this article we apply Gilbert's algorithm to revise previously obtained results for this class. In particular we use ''entanglement cartography'' to argue that most states left in [Hiesmayr, B. C. {\em Scientific Reports} {\bf 11}, 19739 (2021)] as unknown to be entangled or separable are most likely indeed separable, or very weakly entangled, beyond any practical relevance. The presented technique can find endless applications in more general cases.
Antibiotics for UTIs Cause Distinct Alterations in Gut Microbiota and Host Health Compared to Enteritis Treatment
Authors: Liu fengping , Sun Yifan , Xu Zhengyi , Lin Hao , Tang Yifang , Xia Qiang , Wei Shichao , Hu Jialin , Sheng Jiayi , Hu Lei , Guo Wei , Gu Yifeng , Wei Qun , Wang Shiyu , Zhao Yu , Li Zhi , Xu Cheng , Feng Ninghan 
Published: September 2023

Abstract
Background Fecal microbiota transplantation (FMT) has gained attention as a potential treatment for various chronic inflammatory diseases, including colitis and urinary tract infections (UTIs). However, the effects of different antibiotics, especially those used for UTIs, on the gut microbiota and host are not well-studied.
Methods Male Sprague-Dawley rats, 8 weeks old, were subjected to antibiotic cocktails for the treatment of enteritis and UTIs, receiving daily doses of 0.5g and 1g via gavage over a 2-week period. Following this treatment, samples of feces and jejunal tissue were collected for microbiota analysis, and bacterial DNA was subsequently isolated and sequenced using 16S rRNA. The microbial composition, diversity, and abundance were thoroughly assessed. Additionally, a comprehensive evaluation included histomorphological analysis, body weight measurement, food intake monitoring, as well as assessments of liver, renal function, and urinary parameters.
Results Fecal and tissue samples exhibited distinct microbial profiles, with fecal samples being more diverse. Antibiotics, both for enteritis and UTIs, significantly altered microbial communities in fecal samples, reducing richness and diversity. The effects were less pronounced in tissue samples. UTI antibiotics had a more detrimental impact on intestinal histomorphology compared to enteritis antibiotics. Rats on higher UTI antibiotic doses showed lower body weight and reduced food intake. Liver, renal function, and urinary parameters were affected, indicating potential systemic consequences.
Conclusions This study underscores the differential impacts of antibiotics on gut microbiota and host health, particularly emphasizing caution in UTI antibiotic use and advocating further research for mitigation.
Quantitative investigation of rock dynamic failure using Voronoi-based discontinuous deformation analysis
Authors: Zhang Kaiyu , Zhang Lei , Liu Feng , Xia Kaiwen , Yu Yuchao , Wang Shuai 
Published: September 2023

Abstract
Dynamic failure widely exists in rock engineering, such as excavation, blasting, and rockburst. However, the quantitative measurement of the dynamic damage process using experimental methods remains a challenge. In this study, a SHPB modeling technique is established based on Voronoi-based DDA to study the damage evolution of Fangshan granite under dynamic loading. The assessment of cracking along the artificial joints among Voronoi sub-blocks is conducted by employing the modified contact constitutive law. A calibration procedure has been implemented to investigate the rock dynamic properties quantitatively. The dispersion and damping effect can be effectively eliminated by regular discretization in SHPB bars, based on which the dynamic stress equilibrium can be satisfied. To reproduce the loading rate effect of the dynamic compressive strength, which has been observed in the experiment, a modification strategy considering the influence of the rate effect on the strength meso-parameters is proposed. Using this strategy, the peak stresses of the transmitted waves predicted by DDA match well with those obtained from experiments conducted at different loading rates. The simulation results show that more microcracks are generated and the proportion of tensile cracks decreases as the loading rate increases. Furthermore, the dynamic mechanical behavior and fracturing process have also been discussed and compared with the experiments. The results show that the established SHPB system is a powerful tool for quantitative analysis of rock dynamics problems and is capable of handling more complex problems in the future.
Effect of perioperative factors on short-term outcomes in patients with non-small cell lung cancer over 60 years of age
Authors: Zhu Wenzhi , Yang Jiaonan , Wang Xiaoyi , Ji Xinqiang , Tan Hongyu 
Published: September 2023

Abstract

Background: People in China have gradually entered old age society, and the number of lung cancer cases is expected to increase annually among the elderly. This study aimed to retrospectively explore the association between perioperative factors and short-term outcomes in elderly patients with non-small cell lung cancer (NSCLC).
Methods: A total of 490 elderly patients with NSCLC between January 1, 2003, and December 31, 2009, were selected. Perioperative factors were grouped and analyzed according to postoperative complications and length of hospital stay. A logistic regression analysis model was used to screen for the independent predictors of patient prognosis. The primary endpoint was postoperative complications and the secondary endpoint was postoperative hospital stay.
Results: Of all patients, 344 (70.2%) developed postoperative complications, and the average length of stay after surgery was14.0±5.6 days. Perioperative fentanyl equivalents＞28.7μg/kg and duration of surgery＞4.4h were associated were associated with an increased risk of PPCs (P < 0.05);intraoperative blood loss(IBL) > 200 ml was associated with extended hospital stay (P < 0.05).
Conclusions: This study suggested that Perioperative factors may affect the short-term prognosis of elderly NSCLC patients after surgery. Perioperative fentanyl equivalents＞28.7μg/kg, surgery duration, and IBL may be independent predictors of short-term outcomes in elderly patients.
Research and Application of automatic train loading line and intelligent cleaning robot of dry bulk terminal
Authors: weili Zhao , shoushui Yu , jie Zhang , lei Li , xuexu Ma , fuqian Liu 
Published: September 2023

Abstract
The ship cleaning operation is an indispensable job link in the bulk unloading operation. In the late ship unloading, it is difficult to capture the four-week goods in the cabin and unloading machinery. During the existing cleaning process, unloading machinery (grab), cabin machinery, cleaning workers, etc.At the same time, in the current epidemic environment, the risk of infection with neozoppneumitis is also increasing.In response to the outstanding problems in the above-mentioned clearing, the automated transformation of loaders and excavators, automated transformation of the door, and the development of the clearing equipment, and the electronic upper rod system are implemented.All the hatch commanders are all unmanned, while ensuring the efficiency of the cleans, completely eliminating the safety risks of personal injury.
Spatial Distribution of Under-five Mortality at the Zone Level in Ethiopia
Authors: Gagabo Sisay Yohannes , Debeko Dereje Danbe 
Published: September 2023

Abstract

Background
Despite remarkable rate declines, about 5.6 million children worldwide still die before turning five every year. In 2016, 67 out of every 1,000 babies in Ethiopia died before they reached five, according to the Ethiopian Demographic and Health Survey (EDHS). This study aimed to study the spatial distribution of under-five mortality (U5M) at the zone level in Ethiopia using data from the 2016 EDHS.
Methods
The EDHS, 2016, provided the information used in this investigation. The distribution of under-five mortality throughout the regions of Ethiopia was identified using spatial analysis to find hot and cold spot zones.
Results
In Ethiopia, there was a geographical clustering of the U5M distribution (Moran's I = 0.97, p-value = 0.00). The regions of Afar, Benshangul-Gumuz, Somalia, and Gambela were found to have hot zones of U5M, while Addis Ababa and Tigray were found to have cold zones.
Conclusion
Ethiopia's regions were spatially and geographically concentrated in terms of under-five mortality, while host spot zones were identified in less developed areas of the nation. There was a sizable regional variance in under-five mortality. A multi-sectoral approach to reducing geographical disparities, raising public awareness about the use of health services, and taking effective action to address the causes of under-five mortality can significantly lessen the issue in Ethiopia.
Dynamic Characteristics and Reinforcement Mechanism of Silty Soil Improved by Regenerated Fiber Polymer
Authors: Liu Lulu , Zhao Jinpeng , Liu Xiaoyan , Lv Shixin 
Published: September 2023

Abstract
The advancement of reinforcement technologies and the enhancement of dynamic stability in subgrade silty soils contribute to sustainable civil engineering practices. To achieve these objectives, this study employs fiber polymers and inorganic curing agents to optimize the mechanical properties of subgrade silty soils. Utilizing dynamic triaxial testing and Scanning Electron Microscopy (SEM), the study examines both the dynamic behavior and microstructural mechanisms of the engineered soil. The principal findings are threefold. First, optimum dynamic stability is attained when the fiber content in the modified subgrade silty soil is at 0.2%. Second, an increase in confining pressure enhances the quasi-cohesion of the fiber-reinforced soil. Lastly, cementitious materials coat the micro-particle surfaces of the enhanced soil, linking the smaller soil particles to fill interstitial spaces, thus yielding a more compact and stable soil structure and improving the dynamic behavior of the fiber-reinforced soil.