bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-1 Superfamily Member (IL-1A, IL-1B and IL-18) Genetic Variants Influence Susceptibility and Clinical Course of Mediterranean Spotter Fever
Authors: Scola Letizia , Pilato Giovanni , Giarratana Rosa Maria , Sanfilippo Giuseppa Luisa , Lio Domenico , Colomba Claudia , Giammanco Giovanni Maurizio 
Published: December 2022

Mediterranean Spotted Fever (MSF) is one of the most common spotted fever Rickettsioses. Most cases of MSF follow a benign course, with a minority of cases being fatal. The severity of the infection depends on bacterial virulence, dose and host factors such as effective immune response and genetic background. Herein, we reported data on typing by competitive allele-specific PCR of functionally relevant polymorphisms of genes coding for MyD88 adapter-like (Mal/TIRAP) protein (rs8177374), interleukin(IL)-1 cluster (IL-1A rs1800587, IL-1B rs16944 and rs1143634) and IL-18 (rs187238), which might be crucial for an efficient immune response. The results enlighten the role that IL-1 gene cluster variants might play in susceptibility against Rickettsia conorii infection. In particular, the IL-1A rs1800587TT genotype was significantly increased in patients alone and combined in a haplotype composed by minor alleles rs1800587T, rs16944A and rs1143634A. This result was confirmed using the decision tree heuristic approach. Using this methodology, IL-1A rs1800587TT genotype was the better discrimination key among MSF patients and controls. In addition, the IL-1 gene cluster SNP genotypes containing minor alleles and IL-18 rs187238G positive genotypes were found as associated with risk of severe complications such as sepsis, septic shock, acute respiratory distress syndrome and coma. In conclusion, these data suggest that the evaluation of IL-1A, IL-1B and IL-18 gene SNPs can add useful information on the clinical course of patients affected by Mediterranean Spotted Fever, even if further confirmatory studies will be necessary.
QTLs Related to Rice Callus Regeneration Ability: Localization and Effect Verification of qPRR3
Authors: Wu Jiemin , Chang Xinlei , Li Chuanhong , Zhang Zhaoyang , Zhang Jianguo , Yin Changxi , Ma Weihua , Chen Hao , Zhou Fei , Lin Yongjun 
Published: December 2022

Mature and efficient tissue culture systems are already available for most japonica rice varieties (Oryza sativa ssp. geng). However, it remains challenging to regenerate the majority of indica rice varieties (Oryza sativa ssp. xian). In this study, quantitative trait loci (QTLs) associated with rice callus regeneration ability were identified based on the plant regeneration rate (PRR) and total green plant rate (TGPR) of the 93-11 × Nip recombinant inbred line population. Significant positive correlations were found between PRR and TGPR. A total of three QTLs (one for PRR and two for TGPR) were identified. qPRR3 (located on chromosome 3) was detected for both traits, which could explain 13.40% and 17.07% of the phenotypic variations of PRR and TGPR, respectively. Subsequently, the effect of qPRR3 on callus regeneration ability was validated by cryptographically tagged near-isogenic lines (NILs), and the QTL was narrowed to an interval of approximately 160 kb. The anatomical structure observation of the regenerated callus of the NILs revealed that qPRR3 can improve the callus regeneration ability by promoting the regeneration of shoots.
Effect of Superovulation Treatment on Oocyte’s DNA Methylation
Authors: Lopes Jordana S. , Ivanova Elena , Ruiz Salvador , Andrews Simon , Kelsey Gavin , Coy Pilar 
Published: December 2022

Controlled ovarian stimulation is a necessary step in some assisted reproductive procedures allowing a higher collection of female gametes. However, consequences of this stimulation for the gamete or the offspring have been shown in several mammals. Most studies used comparisons between oocytes from different donors, which may contribute to different responses. In this work, we use the bovine model in which each animal serves as its own control. DNA methylation profiles were obtained by single-cell whole-genome bisulfite sequencing of oocytes from pre-ovulatory unstimulated follicles compared to oocytes from stimulated follicles. Results show that the global percentage of methylation was similar between groups, but the percentage of methylation was lower for non-stimulated oocytes in the imprinted genes APEG3, MEG3, and MEG9 and higher in TSSC4 when compared to stimulated oocytes. Differences were also found in CGI of imprinted genes: higher methylation was found among non-stimulated oocytes in MEST (PEG1), IGF2R, GNAS (SCG6), KvDMR1 ICR UMD, and IGF2. In another region around IGF2, the methylation percentage was lower for non-stimulated oocytes when compared to stimulated oocytes. Data drawn from this study might help to understand the molecular reasons for the appearance of certain syndromes in assisted reproductive technologies-derived offspring.
Mycorrhizal Effects on Growth and Expressions of Stress-Responsive Genes (aquaporins and SOSs) of Tomato under Salt Stress
Authors: Liang Sheng-Min , Li Qiu-Shuang , Liu Ming-Yang , Hashem Abeer , Al-Arjani Al-Bandari Fahad , Alenazi Mekhled M. , Abd_Allah Elsayed Fathi , Muthuramalingam Pandiyan , Wu Qiang-Sheng 
Published: December 2022

Environmentally friendly arbuscular mycorrhizal fungi (AMF) in the soil can alleviate host damage from abiotic stresses, but the underlying mechanisms are unclear. The objective of this study was to analyze the effects of an arbuscular mycorrhizal fungus, Paraglomus occultum, on plant growth, nitrogen balance index, and expressions of salt overly sensitive genes (SOSs), plasma membrane intrinsic protein genes (PIPs), and tonoplast intrinsic protein genes (TIPs) in leaves of tomato (Solanum lycopersicum L. var. Huapiqiu) seedlings grown in 0 and 150 mM NaCl stress. NaCl stress severely inhibited plant growth, but P. occultum inoculation significantly improved plant growth. NaCl stress also suppressed the chlorophyll index, accompanied by an increase in the flavonoid index, whereas inoculation with AMF significantly promoted the chlorophyll index as well as reduced the flavonoid index under NaCl conditions, thus leading to an increase in the nitrogen balance index in inoculated plants. NaCl stress regulated the expression of SlPIP1 and SlPIP2 genes in leaves, and five SlPIPs genes were up-regulated after P. occultum colonization under NaCl stress, along with the down-regulation of only SlPIP1;2. Both NaCl stress and P. occultum inoculation induced diverse expression patterns in SlTIPs, coupled with a greater number of up-regulated TIPs in inoculated versus uninoculated plants under NaCl stress. NaCl stress up-regulated SlSOS2 expressions of mycorrhizal and non-mycorrhizal plants, while P. occultum significantly up-regulated SlSOS1 expressions by 1.13- and 0.45-fold under non-NaCl and NaCl conditions, respectively. It was concluded that P. occultum inoculation enhanced the salt tolerance of the tomato, associated with the nutrient status and stress-responsive gene (aquaporins and SOS1) expressions.
Systematic Evaluation for the Impact of the Geological Conditions on the Adsorption Affinities of Calcite as an Adsorbent of Zn2+ Ions from Aqueous Solutions: Experimental and Theoretical Studies
Authors: Nasser Nourhan , El-Sayed Mohamed I. , Othman Sarah I. , Allam Ahmed A. , Al-Labadi Ibrahim G. , Abukhadra Mostafa R. , Bellucci Stefano 
Published: December 2022

Three samples of calcite (calcite crystal (CA), calcite of limestone (L.CA), and metamorphosed calcite (marble) (M.CA)) were assessed as adsorbents of Zn (II) to consider the impact of the different geological conditions. The three samples exhibit remarkable changes in their Zn (II) retention capacities (Qsat = 384.6 mg/g (CA), 274.5 mg/g (L.CA), and 512.6 mg/g (M.CA)). The retention systems of the three calcite samples were described on the basis of the suggested statistical physics-based equilibrium studies as well as the traditional kinetic and isotherm models. However, the M.CA samples exhibited the best retention capacity, the steric properties reflecting a higher active site density of CA (Nm (Zn) = 113.46 mg/g) than both M.CA (Nm (Zn) = 82.8 mg/g) and L.CA (Nm (Zn) = 52.4 mg/g) at 323 K. This was assigned to the controlling effect of the sequestered numbers of Zn (II) per site on the surfaces of the calcite phase (n(Zn) = 3.39 (CA), 5.24 (L.CA), and 6.19 (M.CA)) in addition to the higher surface area and ion exchange of the metamorphosed and deformed M.CA. The previous n(Zn) values suggested the retention of Zn (II) by a multi-ionic mechanism in a vertical orientation. The Gaussian energies (8 to 16 KJ/mol) and retention energies (˂40 KJ/mol) of Zn (II) by CA and L.CA suggested complex physical and weak chemical mechanisms involving ion exchange, hydrogen bonding, dipole bonding forces, electrostatic attractions, and van der Waals forces. The thermodynamic properties were illustrated on the basis of the internal energy, free enthalpy, and entropy functions, which validate the endothermic and spontaneous nature of the Zn (II) retention system by the three calcite samples.
Risk and Timing of De Novo Sepsis in Critically Ill Children after Acute Kidney Injury
Authors: Formeck Cassandra L. , Feldman Robert , Althouse Andrew D. , Kellum John A. 
Published: December 2022

Key Points

Critically ill children who developed AKI have a 42% increase in the probability of developing subsequent hospital-acquired sepsis when compared with children without AKI.When evaluating risk of sepsis over time, children with stage 3 AKI remain at increased risk for sepsis for at least 2 weeks after AKI onset.Medical providers should monitor for signs of sepsis after AKI and limit exposures that may increase the risk for infection.

Background
AKI is common among critically ill children and is associated with an increased risk for de novo infection; however, little is known about the epidemiology and temporal relationship between AKI and AKI-associated infection in this cohort.

Methods
We conducted a single-center retrospective cohort study of children admitted to the pediatric and cardiac intensive care units (ICUs) at a tertiary pediatric care center. The relationship between nonseptic AKI and the development of hospital-acquired sepsis was assessed using Cox proportional hazards models using AKI as a time-varying covariate.

Results
Among the 5695 children included in this study, AKI occurred in 20.2% from ICU admission through 30 days. Hospital-acquired sepsis occurred twice as often among children with AKI compared with those without AKI (10.1% versus 4.6%) with an adjusted hazard ratio of 1.42 (95% confidence interval, 1.12 to 1.81). Among the 117 children who developed sepsis after AKI, 80.3% developed sepsis within 7 days and 96.6% within 14 days of AKI onset, with a median time from AKI onset to sepsis of 2.6 days (interquartile range, 1.5–4.7). When assessing change in risk over time, the hazard rate for sepsis remained elevated for children with stage 3 AKI compared with children without AKI at 13.5 days after AKI onset, after which the estimation of hazard rates was limited by the number of children remaining in the hospital.

Conclusions
AKI is an independent risk factor for de novo sepsis. Critically ill children with stage 3 AKI remain at increased risk for sepsis at 13.5 days after AKI onset.
THE SELECTION OF DANCERS CHARACTERISTICS AND PARTICULARITIES
Authors: Sofron Oana Alina , Țifrea Corina 
Published: December 2022

Problem statement: Dance Sport is a special kind of sport, in a continuous transformation and evolution, whose regulations constantly adapt to society and to the present time and still offer, permanently, a total spectacle. In order for athletes - dancers to assert themselves on the dance floor, in competitions, it is not enough just for their interest or desire to participate. There are a number of mandatory conditions that need to be considered, the first of which is staged selection (respecting and following the selection criteria of each stage ). Given the diversity of forms that selection can take in expression sports (according to certain principles) and at the same time taking stock of the most used terms in the field, we further set out some models and classification criteria but also methods and forms of selection. Selection is a long, organized and repetitive process of detecting the innate availability of children / young people, through the prism of a complex system of criteria (medical, biological, motor, psychological, social and cultural), in order to practice and further specialize in a Dance Sport discipline ( Standard Dances, Latin Dances, Mixed - 10 Dances). The selection model represents a vast structure that can be permanently adapted according to human morphological changes and also, psycho-functional changes. It has multidisciplinary and interdisciplinary characteristics, biological, pedagogical, mental, technical, social and cultural. The model has a pronounced prospective character.
METHODS FOR EVALUATING ANAEROBIC EFFORT CAPACITY OF ATHLETES
Authors: Gheorghe Carmen , Mereuță Claudiu , Postelnicu Mădălina Gabriela 
Published: December 2022

The first purpose of this article was to identify the current methods to assess the anaerobic exercise capacity of athletes, both in the laboratory and in the field of sports competitions. The second purpose of the research was to highlight the factors that limit the ability of anaerobic effort, according to the literature in the field. We found that anaerobic capacity is still difficult to estimate and/or measure, mainly because of the laborious, invasive, and expensive research methodology. To ensure the quality and veracity of the data, strict adherence to test procedures, calibration of instruments, and increased attention to physiological measurements are recommended.
DOSAGE OF THERAPEUTIC EXERCISE ACCORDING TO PATIENTS’ RISK CHART DETERMINED BY BIOIMPEDANCE
Authors: Murgoci Nicolae , Mereuță Claudiu , Nanu Liliana 
Published: December 2022

Introduction. Recommendations regarding the correctness of the therapeutic exercises must take into account the patient's body composition, which can be evaluated by bioimpedance.
Material and method. 21 outpatients were assessed using a single-frequency bioelectrical impedance analyzer (SF-BIA). Health outcomes such as fat mass (FM), fat-free mass imbalances (FFM), and skeletal muscle mass (SMM) were determined. SPSS software version 25 was used for statistical analysis.
Results and discussions. Of the 21 subjects, there are 52.68% men, and 47.62% women. The mean age is 47.81years ± 18.519 Std. Deviation, Body Mass Index (BMI) mean 26.38 ± 5.768, OneSample T-Test Sig..001. Fat-free mass index (FFMI), fat mass index (FMI), and skeletal mass index (SMI) were computed by adjusting with height square. Measuring the variance by ANOVA with one independent variable - BMI and one response variable (FMI Types, FFMI Types), the results were statistically significant. For FMI TypesF(2,18)=9.255, Sig.0.002, the measure of effect sizeEta Squaredη2=50.7%, Cohen medium effect shows that out of the total variation in BMI, the proportion that can be attributed to FMI Types is 50.7%. For FFMI Types F(2, 18)=10.943, Sig.0.001, the measure of effect size Eta Squaredη2=54.9%, Cohen medium effect shows that out of the total variation in BMI, the proportion that can be attributed to FFMI Types is 54.9%. FMI somatotype components results are 71.43% adipose cases, 19.05% intermediate, and 9.52% lean. One-Sample Chi-Square test applied to FMI Types reveals the statistical significance of .05(.001). FFMI somatotype components recorded 57.14% intermediate cases, 23.81% slender, and 19.05% solid. Regression equation of standard BMI and FMI with scatter plots took into consideration the “chair stand test” for pre-sarcopenia with a result of 84.5% No cases and 72.4% Yes cases.Nine patients exceeded 15 seconds at the chair stand test so probable sarcopenia was identified. Pearson correlation of BMI with FMI (r=.898), FFMI (r=.716) and SMI (r=.772), CI=99% Age (r=.518), CI=95% registered strong direct statistical significance. FMI also correlates with Age (r=.602), CI=95%, and FFMI with SMI (r=.984), CI=99%.
Conclusions. Dosage of the therapeutic exercises applied with cardiac parameters monitoring for FMI Adipose (n=15), FFMI Slender, and Intermediate (n=11) includes resistive, concentric exercises, low-medium intensity progressive, pause integration for homeostasis balance, and a long period of rehabilitation for presarcopenia (n=6). For FFMI Solid, eccentric exercise can be added, medium-high intensity, pause integration for homeostasis balance for a short period with cardiac reserve monitoring. The patient's risk chart regarding fat mass and skeletal muscle mass should be included in the rehabilitation process routine to avoid functional impairment and to improve global functionality.
In Gratitude to Professor Leszek Gawor
Authors: Pawłowski Artur 
Published: December 2022

Professor Leszek Gawor decided to resign from being co-editor of the journal due to retirement. Dear Leszek, we would like to thank You very much for the fruitful cooperation lasting over 15 years! Prof. Leszek Gawor graduated in philosophy from the University of Warsaw, Poland in 1978. In the years 1981-2003 he worked at the Institute of Philosophy of the Maria Curie-Skłodowska University in Lublin, Poland. Since 2003 he has been employed at the Institute of Philosophy of the University of Rzeszów, Poland. He obtained his doctorate in 1989 at the Maria Curie-Skłodowska University, and habilitation there in 2000; he became a professor of humanities in 2015. In the years 2015-2018 he was a member of the Committee on Philosophical Sciences of the Polish Academy of Sciences. In the years 2006-2022 he was Co-Editor of Problemy Ekorozwoju/ Problems of Sustainable Development.
Effectiveness of School Management through Strengthening the Managerial Ability of School Principals in the Field of Education Financing
Authors: Widyatmike Gede Mulawarman  , Heriman Heriman , Pratama Prima Adi 
Published: December 2022

Along with the demands of an autonomous environment, it has an impact on the condition of schools that are increasingly competitive. Good management of education costs optimizes school functions to be more efficient and effective so as to improve school performance, quality and competitiveness. The results of the author's observations by observing several complaints from educators in designing activity programs to improve the quality of education require critical educational activities for educators and principals about education finance management. By using the workshop method, it is hoped that the objectives of this PKM activity are (1) providing knowledge to educators in preparing programs according to the education budget and (2) Providing skills in managing education budgets. This activity is designed offline whenever possible in the Meeting Hall at SDN 004 Bontang City and online if participants from outside Bontang City are not possible (during the COVID-19 Pandemic) to be carried out using the Zoom application. The methods used are explanatory methods, demonstrations and practices by means of seeding and questioning. The implementation of activities is carried out by providing material on strategic management of program preparation. The expected result in this training is that all skilled educators develop a program of activities with the preparation of the right budget
PENGEMBANGAN MEDIA INTERAKTIF BERBASIS MACROMEDIA FLASH 8 PADA TEMA PEDULI TERHADAP MAKHLUK HIDUP KELAS IV SEKOLAH DASAR
Authors: Bayutama Laksa , Reffiane Fine , Huda Choirul 
Published: December 2022

Semangat dan antusias siswa hanya diawal kegiatan pembelajaran. Hal tersebut disebabkan kurangnya guru menggunakan media pembelajaran. Penerapan kurikulum 2013 yang mengharuskan mengharuskan guru satu media pembelajaran yang dapat digunakan untuk beberapa mata pelajaran dan terbatasnya koleksi media pembelajaran tematik di sekolah. Guru perlu menggunakan media yang menarik dalam menyampaikan meteri pelajaran, salah satu solusinya dengan menggunakan media interaktif berbasis macromedia flash 8. Penelitian ini bertujuan untuk mengetahui kevalidan dan kepraktisan media interaktif berbasis macromedia flash 8 pada tema peduli terhadap mahkhluk hidup kelas IV Sekolah Dasar. Penelitian ini menggunakan metodologi penelitian Research and Development (R&D). Langkah-langkah untuk mengembangkan media interaktif berbasis macromedia flash 8 menggunakan prosedur pengembangan model ADDIE (Analysis, Design, Development, Implementation. and Evaluation). Kevalidan media diperoleh dari hasil validasi ahli yang terdiri dari tiga ahli media dan tiga ahli materi. Hasil yang diperoleh dari ahli media I 97,5%, ahli media II 97,5% dan ahli media III 100%. Hasil yang diperoleh dari ahli materi I 98,33%, ahli materi II 98,33% dan ahli materi III 96,66%. Rata-rata hasil yang diperoleh dari tiga ahli media 98,33% dan ahli materi 97,77% dengan kriteria â€œSangat Layak Digunakanâ€. Kepraktisan media diperoleh melalui angket tanggapan siswa dan guru kelas IV SDN Bendokatonkidul, SDN Purwokerto 01 dan SDN Tayu Wetan 01 terhadap media interaktif berbasis macromedia flash 8. Hasil angket tanggapan siswa kelas IV SDN Bendokatonkidul 98,59%, SDN Purwokerto 01 100% dan SDN Tayu Wetan 01 98,78%. Hasil angket tanggapan guru kela IV SDN Bendokatonkidul 100%, SDN Purwokerto 01 sebesar 95% dan SDN Tayu Wetan 01 92,5%. Rata rata dari angket tanggapan siswa sebesar 99,12% dan angket tanggapan guru sebesar 95,83% dengan kriteria â€œSangat Layak Digunakanâ€. Kesimpulan bahwa media interaktif berbasis macromedia flash 8 valid dan praktis digunakan pada tema peduli terhadap makhluk hidup kelas IV Sekolah Dasar.
CIDADES, GLOBALIZAÇÃO E DETERMINISMO ECONÔMICO
Authors: De Souza Marcelo Lopes 
Published: December 2022

No que se refere às cidades, uma interpretação que se difunde rapidamente pelo mundo é aquela associada ao chamado “empresarialismo urbano”. Os seus adeptos tendem a ver com nítido otimismo a globalização e os seus efeitos sobre as cidades. Argumentam, tipicamente, que o Estado-nação teria se tornado “pequeno demais" em face do grande capita! transnacional, ao passo que, para a promoção ágil do desenvolvimento econômico e do bem-estar dos cidadãos, mostrar-se-la “grande demais”. Para eles, uma cidade deveria funcionar tal qual uma empresa, concorrendo com outras cidades para atrair capitais, cabendo ao Estado o papel de costurar “consensos” e ajudar a criar um bom “ambiente de negócios”. Uma interpretação concorrente, notadamente no Brasil, é a representada pelo ideário da reforma urbana. Aqueles que com esta posição se identificam tendem a assumir uma postura crítica em face da globalização capitalista. Recusam a atração de investimentos a qualquer preço, priorizando a meta da redução de desigualdades. Mesmo quando admitem um certo encolhimento da margem de manobra do Estado, rejeitam qualquer determinismo, e tampouco concordam com a idéia de que o Estado local deveria concentrar-se em “criar um clima de negócios favorável”. Reconhecer a relevância e algum tipo de papel positivo para o Estado, em matéria de políticas públicas, entretanto, não pressupõe que o papel da sociedade civil deva ser circunscrito a esquemas participativos tutelados pelo Estado. Acentuar isso, seja direta ou indiretamente, parece ser justamente a contribuição de certos movimentos sociais da atualidade para uma renovação do ideário da reforma urbana — urgentemente necessária em face da marcha avassaladora do “empresarialismo urbano”.