bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planning ahead: Predictable switching recruits task‐active and resting‐state networks
Authors: Kurtin Danielle L. , Araña‐Oiarbide Garazi , Lorenz Romy , Violante Ines R. , Hampshire Adam 
Published: July 2023

AbstractSwitching is a difficult cognitive process characterised by costs in task performance; specifically, slowed responses and reduced accuracy. It is associated with the recruitment of a large coalition of task‐positive regions including those referred to as the multiple demand cortex (MDC). The neural correlates of switching not only include the MDC, but occasionally the default mode network (DMN), a characteristically task‐negative network. To unpick the role of the DMN during switching we collected fMRI data from 24 participants playing a switching paradigm that perturbed predictability (i.e., cognitive load) across three switch dimensions—sequential, perceptual, and spatial predictability. We computed the activity maps unique to switch vs. stay trials and all switch dimensions, then evaluated functional connectivity under these switch conditions by computing the pairwise mutual information functional connectivity (miFC) between regional timeseries. Switch trials exhibited an expected cost in reaction time while sequential predictability produced a significant benefit to task accuracy. Our results showed that switch trials recruited a broader activity map than stay trials, including regions of the DMN, the MDC, and task‐positive networks such as visual, somatomotor, dorsal, salience/ventral attention networks. More sequentially predictable trials recruited increased activity in the somatomotor and salience/ventral attention networks. Notably, changes in sequential and perceptual predictability, but not spatial predictability, had significant effects on miFC. Increases in perceptual predictability related to decreased miFC between control, visual, somatomotor, and DMN regions, whereas increases in sequential predictability increased miFC between regions in the same networks, as well as regions within ventral attention/ salience, dorsal attention, limbic, and temporal parietal networks. These results provide novel clues as to how DMN may contribute to executive task performance. Specifically, the improved task performance, unique activity, and increased miFC associated with increased sequential predictability suggest that the DMN may coordinate more strongly with the MDC to generate a temporal schema of upcoming task events, which may attenuate switching costs.
Disability and persistent motor deficits are linked to structural crossed cerebellar diaschisis in chronic stroke
Authors: Guder Stephanie , Sadeghi Fatemeh , Zittel Simone , Quandt Fanny , Choe Chi‐un , Bönstrup Marlene , Cheng Bastian , Thomalla Götz , Gerloff Christian , Schulz Robert 
Published: July 2023

AbstractBrain imaging has significantly contributed to our understanding of the cerebellum being involved in recovery after non‐cerebellar stroke. Due to its connections with supratentorial brain networks, acute stroke can alter the function and structure of the contralesional cerebellum, known as crossed cerebellar diaschisis (CCD). Data on the spatially precise distribution of structural CCD and their implications for persistent deficits after stroke are notably limited. In this cross‐sectional study, structural MRI and clinical data were analyzed from 32 chronic stroke patients, at least 6 months after the event. We quantified lobule‐specific contralesional atrophy, as a surrogate of structural CCD, in patients and healthy controls. Volumetric data were integrated with clinical scores of disability and motor deficits. Diaschisis‐outcome models were adjusted for the covariables age, lesion volume, and damage to the corticospinal tract. We found that structural CCD was evident for the whole cerebellum, and particularly for lobules V and VI. Lobule VI diaschisis was significantly correlated with clinical scores, that is, volume reductions in contralesional lobule VI were associated with higher levels of disability and motor deficits. Lobule V and the whole cerebellum did not show similar diaschisis‐outcome relationships across the spectrum of the clinical scores. These results provide novel insights into stroke‐related cerebellar plasticity and might thereby promote lobule VI as a key area prone to structural CCD and potentially involved in recovery and residual motor functioning.
What factors are considered in hospital funding models? A review of the literature on health services funding in organisation for economic co‐operation and development countries
Authors: Clay‐Williams Robyn , Zurynski Yvonne , Long Janet C. , Meulenbroeks Isabelle , Austin Elizabeth E. , Mahmoud Zeyad , Ellis Louise A. , Knaggs Gilbert , Fajardo Pulido Diana , Richardson Lieke , Ahlenstiel Golo , Reece Graham , Braithwaite Jeffrey 
Published: July 2023

AbstractBackgroundOne of the most difficult challenges in healthcare involves equitable allocation of resources. Our review aimed to identify international funding models in Organisation for Economic Co‐operation and Development (OECD) countries for government‐funded public hospitals and evidence underpinning their efficacy, via review of the peer‐reviewed and grey literature.MethodsOvid‐Medline, Ovid Embase, Scopus, and PubMed were searched for peer‐reviewed literature. Advanced Google searches and targeted hand searches of relevant organisational websites identified grey literature. Inclusion criteria were: English language, published between 2011 and 2022, and that the article: (1) focused on healthcare funding; (2) reported on or identified specific factors, indexes, algorithms or formulae associated with healthcare funding; and (3) referred to countries that are members of the OECD, excluding the United States (US).ResultsFor peer‐reviewed literature 1189 abstracts and 35 full‐texts were reviewed; six articles met the inclusion criteria. For grey literature, 2996 titles or abstracts and 37 full‐texts were reviewed; five articles met the inclusion criteria. Healthcare funding arrangements employed in 15 OECD countries (Australia, Belgium, Canada, Finland, France, Germany, Israel, Italy, the Netherlands, New Zealand, Norway, Spain, Sweden, Switzerland, and the United Kingdom [UK; specifically, England, Scotland, Wales and Northern Ireland]) were identified, but papers reported population‐based funding arrangements for specific regions rather than hospital‐specific models.ConclusionsWhile some models adjusted for deprivation and ethnicity factors, none of the identified documents reported on health systems that adjusted funding allocation for social determinants such as health literacy levels.
Risk‐stratified management strategies for intrahepatic cholestasis of pregnancy: A tertiary center population review over nearly 5 years
Authors: Xu Tingting , Zhan Yongchi , Chen Daijuan , Deng Xixi , Mao Chihui , Xu Jinfeng , Wang Xing , Guo Bing , Wang Xiaodong 
Published: July 2023

AbstractObjectiveIntrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of adverse perinatal outcomes, resulting in a higher risk of perinatal morbidity and mortality.MethodsThe authors conducted a retrospective study of 2385 singletons with ICP who underwent risk‐stratified management strategies. To explore the risks of perinatal outcomes of ICP, subgroup analyses were performed using different total bile acid (TBA) levels.ResultsIn this study, there was only one stillbirth and one neonatal death. Among the study cohort, 2299 patients had ICP with a TBA level ≥10 μmol/L and 86 had ICP with a TBA level <10 μmol/L. The 2299 patients with ICP (TBA level ≥ 10 μmol/L) were divided into three groups: mild ICP (n = 1803), severe ICP (n = 400), and extremely severe ICP (n = 96). Increased TBA concentration was associated with an increased incidence of preterm birth, newborn asphyxia, neonatal intensive care unit hospitalization, meconium‐stained amniotic fluid, and low birth weight in the three groups (P < 0.05). Furthermore, severe and extremely severe ICP with hypotonic absonant uterine contraction had a significant effect on neonatal asphyxia (odds ratio, 5.06 [95% confidence interval, 1.09–23.37]; P < 0.05) and meconium‐stained amniotic fluid (odds ratio, 2.37 [95% confidence interval, 1.43–3.93]; P < 0.05).ConclusionsHypotonic absonant uterine contractions could be high‐risk stressors for severe and extremely severe ICP; hence, proper prenatal care is recommended. Risk‐stratified management strategies for ICP are critical to obtaining better maternal‐fetal outcomes.
Effects of transfusing older red blood cells and platelets on obstetric patient outcomes: A retrospective cohort study
Authors: Obonyo Nchafatso G. , Lu Lawrence Y. , White Nicole M. , Sela Declan P. , Rachakonda Reema H. , Teo Derek , Tunbridge Matthew , Sim Beatrice , See Hoe Louise E. , Fanning Jonathon P. , Tung John‐Paul , McKnoulty Matthew , Bassi Gianluigi Li , Suen Jacky Y. , Fraser John F. 
Published: July 2023

AbstractObjectiveTo investigate associations between transfusion of blood products close to the end of shelf‐life and clinical outcomes in obstetric inpatients.MethodsMortality and morbidity were compared in patients transfused exclusively with red blood cells (RBC) stored for less than 21 days (fresh) versus RBC stored for 35 days or longer (old), and platelets (PLT) stored for 3 days or fewer (fresh) versus 4 days or longer (old) in Queensland, Australia from 2007 to 2013. Multivariable models were used to examine associations between these groups of blood products and clinical end points.ResultsThere were 3371 patients who received RBC and 280 patients who received PLT of the eligible storage durations. Patients transfused with old RBC received fewer transfusions (2.7 ± 1.8 vs. 2.3 ± 1.0 units; P < 0.001). However, a higher rate of single‐unit transfusions was also seen in those patients who exclusively received old RBC (252 [9.3%] vs. 92 [13.7%]; P = 0.003). Comparison of fresh vs. old blood products revealed no differences in the quantities of transfused RBC (9.5 ± 5.9 vs. 9.1 ± 5.2 units; P = 0.680) or PLT (1.5 ± 0.8 vs. 1.4 ± 1.1 units; P = 0.301) as well as the length of hospital stay for RBC (3 [2–5] vs. 3 [2–5] days; P = 0.124) or PLT (5 [4–8] vs. 6 [4–9] days; P = 0.120).ConclusionTransfusing exclusively older RBC or PLT was not associated with increased morbidity or mortality.
Regioselective synthesis of multi‐functionalized benzopyranophenazine derivatives: Comparative studies on corrosion inhibition efficiency on mild steel in 1M H2SO4 solution
Authors: Leelakrishnan Saraswathi , Elumalai Dhanasekar , Nachimuthu Gunavathy , Pitchaipillai Muthukrishnan , Jayabal Kamalraja 
Published: July 2023

AbstractObjectivesA regioselective approach has been developed for the synthesis of benzopyranophenazine derivatives using In (OTf)3 as a catalyst in one‐pot synthesis. Further, these synthesized compounds were successfully used as organic corrosion inhibitors on mild steel in 1M H2SO4 solution.MethodsThe synthesized organic inhibitors were confirmed using NMR, and HRMS and their regioselectivity was confirmed by DFT studies using the B3LYP/6‐31G (d, p) basis set. Further, the corrosion, and inhibition efficiencies were confirmed by various methods such as weight loss technique, electrochemical impedance spectroscopy, and potentiodynamic polarization studies.ResultsThe two synthesized compounds MBPPand BBPP show excellent corrosion inhibition properties than the previously reported organic inhibitors, especially, the electron‐donating nature of methoxy‐substituted phenazine derivatives show superior corrosion inhibition properties as 98.96 in 900 ppm than electron withdrawing bromo substituted phenazine derivative in the same concentration which indicates that the electronic structure of the organic inhibitor plays an important role in the corrosion inhibition efficiency of mild steel in an acid medium.ConclusionThe synthesized compound efficiently inhibits the corrosion on the mild steel surface and it forms a barrier on the metal surface. As a result, the phenazine derivatives of both MBPP and BBPP act as very effective corrosion inhibitors and the electron‐donating nature of MBPP shows more inhibition efficiency than BBPP inhibitors.
Youth perspectives of working with near peer youth lay counsellors: The Safe Haven Pilot
Authors: Garriott Anna , Gulubane Godwill , Poku Ohemaa B. , Archibald Nicole , Entaile Patlo , Tshume Ontibile , Phoi Onkemetse , Matshaba Mogomotsi , Ahmed Charisse V. , Lowenthal Elizabeth D. , Brooks Merrian 
Published: July 2023

AbstractYouth living with HIV (YLWH) have higher rates of common mental disorders (CMDs) when compared with HIV‐negative youth. We adapted the Friendship Bench to create a problem solving‐based counselling intervention in Botswana delivered by near peer youth lay counsellors for YLWH called Safe Haven. In August 2020, and from June to August 2021, we conducted 22 semistructured interviews with youth aged 13–25 years with mild‐to‐moderate symptoms of CMDs. Two independent coders carried out an inductive thematic analysis of the transcribed interviews with discrepancies discussed to consensus. Safe Haven was seen as largely acceptable among the youth. Youth felt Safe Haven was a place where they had freedom of expression and could receive practical advice from well‐trained and approachable counsellors. Trained youth lay peer counsellors show promise to meet the mental health needs of mild and moderately symptomatic youth, where mental health professionals are in short supply.
Nanoarchitectonics of Bimetallic MOF@Lab‐Grade Flexible Filter Papers: An Approach Towards Real‐Time Water Decontamination and Circular Economy
Authors: Rego Richelle M. , Ajeya Kanalli V. , Jung Ho‐Young , Kabiri Shervin , Jafarian Mehdi , Kurkuri Mahaveer D. , Kigga Madhuprasad 
Published: July 2023

AbstractThis study presents a novel approach to decontaminate ferrocyanide‐contaminated wastewater. The work effectively demonstrates the use of bimetallic Mo/Zr‐UiO‐66 as a super‐adsorbent for rapid sequestration of Prussian blue, a frequently found iron complex in cyanide‐contaminated soils/groundwater. The exceptional performance of Mo/Zr‐UiO‐66 is attributed to the insertion of secondary metallic sites, which deliver synergistic effects, benefiting the inherent qualities of the framework. Moreover, to extend the industrial applications of metal‐organic frameworks (MOFs) in real‐world scenarios, an approach is delivered to structure the nanocrystalline powders into MOF‐based macrostructures. The work demonstrates an interfacial process to develop continuous MOF nanostructures on ordinary laboratory‐grade filter papers. The novelty of the work lies in the development of robust free‐standing filtration materials to purify PB dye‐contaminated water. Additionally, the work embraces a circular economy concept to address problems related to resource scarcity, excessive waste production, and maintenance of economic benefits. Consequently, the PB dye‐loaded adsorbent waste is re‐employed for the adsorption of heavy metals (Pb2+ and Cd2+). Simultaneously, the study aims to address the problems related to the real‐time handling of powdered adsorbents, and the generation of ecologically harmful secondary waste, thereby, progressing toward a more sustainable system.
Reinforcement detail: Stress trajectory‐oriented corbel reinforcement
Authors: Hoffmann Lars , Käseberg Stefan , Holschemacher Klaus 
Published: July 2023

AbstractThe article presents a novel design of concrete corbels, where horizontal and vertical stirrups are replaced by main reinforcement bars that are bent down into the corbel web, following the principal stress lines. A test series of three specimen pairs of fanned‐out and conventional reinforcement design, supported by finite element analysis, shows that the same capacity can be achieved with a significantly lower amount of reinforcement steel and a higher ductility.
Regulatory mechanism of RNA binding motif protein 15‐mediated N6 methyladenosine modification in proliferation, invasion, and migration of colorectal cancer cells
Authors: Chen Jiangmu 
Published: July 2023

AbstractThis study aims to explore the regulatory mechanism of RNA binding motif protein 15 (RBM15) on the proliferation, invasion, and migration of colorectal cancer (CRC) cells. RBM15, KLF1, or SIN3A expression in CRC tissues and cells was detected by RT‐qPCR or Western blot. CRC cell functions were measured by CCK‐8, colony formation, and Transwell assays after RBM15 intervention. MeRIP and RIP measured N6 methyladenosine (m6A) and IGF2BP3 enrichment on KLF1 mRNA. ChIP and dual‐luciferase analyzed KLF1 enrichment on SIN3A promoter. Combined experiments verified the effect of KLF1/SIN3A on CRC cell functions. Lung/liver metastasis models were established to validate the effect of RBM15 on CRC in vivo. RBM15, KLF1, and SIN3A were highly expressed in CRC. RBM15 knockdown reduced the proliferation, invasion, and migration of CRC cells in vitro. Mechanistically, RBM15 facilitated KLF1 mRNA stability and expression through IGF2BP3‐dependent m6A modification, thus promoting KLF1 enrichment on the SIN3A promoter and activating SIN3A transcription. Overexpression of KLF1 or SIN3A reversed the inhibitory effect of RBM15 knockdown on CRC cells. In vivo experiments verified that RBM15 promoted tumorigenesis and lung/liver metastasis via KLF1/SIN3A axis. In conclusion, RBM15 stimulated CRC proliferation and metastasis by promoting the KLF1/SIN3A axis through IGF2BP3‐dependent m6A modification.
Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos
Authors: Guo Shanshan , Wu Yaqing , Li Wenhua , Xiao Peng 
Published: July 2023

AbstractTralomethrin, a synthetic pyrethroid insecticide used to control a wide range of pests in agriculture and public health, is highly toxic to aquatic organisms. However, data regarding the toxicity and underlying mechanisms of tralomethrin in aquatic organisms are limited. Thus, this study aimed to investigate the toxicity of tralomethrin in zebrafish. Zebrafish embryos were exposed to tralomethrin at different concentrations (16.63, 33.25, and 49.88 μg/L). Results showed that tralomethrin exposure caused cardiovascular dysplasia and dysfunction, including developmental abnormalities (pericardial edema, delayed yolk absorption, and uninflated swim bladder), elevated heart rate, and erythrogenesis disorders. Moreover, the expression patterns of crucial genes responsible for cardiovascular development (alas2, gata1a, hbbe2, nkx2.5, myl7, and myh6) also exhibited dysregulation in response to tralomethrin exposure. Oxidative stress occurred in embryos after exposure to tralomethrin. Collectively, our data suggest that exposure to tralomethrin induces cardiovascular and developmental toxicity in zebrafish. These findings are instrumental for evaluations of the environmental risk of tralomethrin in aquatic ecosystems in the future.
Application of best subset method for river water quality modeling: A study on Godavari River, India
Authors: Chintalacheruvu Madhusudana Rao , Modi Prakhar 
Published: July 2023

AbstractThe utilization of water quality analysis to inform optimal decision‐making is imperative to achieve sustainable management of river water quality. A multitude of research works in the past has focused on river water quality modeling. Despite being a precise statistical regression technique that allows for fitting separate models for all potential combinations of predictors and selecting the optimal subset model, the application of best subset method in river water quality modeling is not widely adopted. The current research aims to validate the use of best subset method in evaluating the water quality parameters of the Godavari River, one of the largest rivers in India, by developing regression equations for different combinations of its physicochemical parameters. The study involves in formulating best subset regression equations to estimate the concentrations of river water quality parameters while also identifying and quantifying their variations. A total of 17 water quality parameters are analyzed at 13 monitoring sites using 13 years (1993–2005) of observed data for the monsoon (June–October) period and post‐monsoon (November–February) period. The final subset model is selected among model combinations that are developed for each year's dataset through widely used statistical criteria such as R2, F value, adjusted R2a, AICc, and RSS. The final best subset model across all parameters exhibits R2 values surpassing 0.8, indicating that the models possess the ability to account for over 80% of the variations in the concentrations of dependent parameters. Therefore, the findings demonstrated the appropriateness of this method in evaluating the water quality parameters in extensive rivers. This work is very useful for decision‐making and in the management of river water quality for its sustainable use in the study area.
Count Me In: Exploring Equity, Diversity, and Inclusion through Mathematics and Children's Literature
Authors: Throop Robinson Evan 
Published: July 2023

AbstractThis article explores the potential of using children's literature in elementary mathematics classrooms as contexts for students to understand more fully the issues of equity, diversity, and inclusion. Informed by culturally responsive pedagogy, opportunities to link children's literature to mathematics education create cultural relevance for students and inspire confidence. An analytic framework for selecting and using children's literature provides a promising tool for teachers to question their resource choices and develop more culturally responsive pedagogy. Suggestions for resources that honor students' cultural identities, backgrounds, and languages offer teachers possibilities for building relationships, thinking mathematically, reading the world, and integrating for learning.
Long-term regulation of fat sensing in rainbow trout (Oncorhynchus mykiss) fed a vegetable diet from the first feeding: focus on free fatty acid receptors and their signalling
Authors: Baranek Elodie , Heraud Cécile , Larroquet Laurence , Surget Anne , Lanuque Anthony , Terrier Frederic , Skiba-Cassy Sandrine , Jérôme Roy 
Published: July 2023

AbstractTaste plays a fundamental role in an animal’s ability to detect nutrients and transmits key dietary information to the brain, which is crucial for its growth and survival. Providing alternative terrestrial ingredients early in feeding influences the growth of rainbow trout (RT, Oncorhynchus mykiss). Thus, the present study aimed to assess the influence, via long-term feeding (from the first feeding to 8 months), of alternative plant ingredients (V diet for vegetable diet v. C diet for a control diet) in RT on the mechanism of fat sensing at the gustatory level. After the feeding trial, we studied the pathways of the fat-sensing mechanism in tongue tissue and the integrated response in the brain. To this end, we analysed the expression pattern of free fatty acid receptors (ffar) 1 and 2, markers of calcium-signalling pathways (phospholipase Cβ, Orai, Stim or Serca), the serotonin level (a key neurotransmitter in taste buds) and the expression pattern of appetite-regulating neuropeptides in the hypothalamus (central area of appetite regulation). The results revealed that the V diet modified the expression pattern of ffar1 and paralogs of ffar2 genes in tongue tissue, along with differential regulation of calcium-signalling pathways and a defect in serotonin level and brain turnover, without influencing neuropeptide expression. This study is the first to support that changes in feeding behaviour of RT fed a V diet could be due to the difference in nutrient sensing and a decrease in hedonic sensation. We revealed that RT have similar fat-detection mechanisms as mammals.