bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transvaginal approach combined intracavitary and interstitial brachytherapy assisted by transrectal ultrasound: results from 30 patients with locally advanced cervical cancer
Authors: Nakashima Takaaki , Matsumoto Keiji , Yoshitake Tadamasa , Wakiyama Hiroaki , Hisano Osamu , Uehara Ryuji , Takaki Masanori , Oshima Takeshi , Yahata Hideaki , Ishigami Kousei 
Published: August 2023

Abstract
Purpose
This study evaluated the efficacy and safety of transvaginal approach combined intracavitary and interstitial brachytherapy (IC/IS BT) assisted by transrectal ultrasound (TRUS) for treatment of locally advanced cervical cancer (LACC).

Materials and Methods
A total of 30 patients of LACC treated with external beam radiotherapy and IC/IS BT via transvaginal approach assisted by transrectal ultrasound were observed retrospectively. The 2-year local control (LC), progression-free survival (PFS), and overall survival (OS) were analyzed using the Kaplan–Meier method. Late adverse events were also evaluated to assess the safety of IC/IS BT.

Results
The median follow-up period was 22 months. The 2-year LC, PFS, and OS were 90%, 61%, and 82%, respectively. We observed no critical complications related to the IC/IS BT technique. Late adverse events of grade 3 or more included one case of grade 4 colon perforation.

Conclusion
Our patient series demonstrated that radiotherapy combined with transvaginal approach, TRUS-assisted IC/IS BT achieves favorable local control and safety for LACC.
Women’s Orgasm and Its Relationship with Sexual Satisfaction and Well-being
Authors: Dienberg Marie-Feline , Oschatz Tanja , Piemonte Jennifer L. , Klein Verena 
Published: August 2023

AbstractPurpose of reviewWomen’s orgasms have been subject to controversial discussions among scholars throughout history. Even today, narratives of women’s orgasm being complicated or less important (cp. to men’s) for their sexual functioning and satisfaction are prevailing and reflected in gendered sexual scripts. This review aims to compile evidence for the relationship between orgasm and sexual well-being in women. We consider orgasm’s role in women’s sexual pleasure, sexual satisfaction, and desire in the context of both casual and committed sexual encounters.Recent findingsSubstantial evidence supports a significant link between orgasm and sexual pleasure, satisfaction, and desire in women. Orgasm has been identified as an important factor in predicting relational satisfaction as well as positive outcomes of casual sex. For instance, orgasming during casual sex completely accounts for the persistent gender differences researchers have observed in emotional and evaluative responses to casual encounters.SummaryAs we cover in this review, there is no shortage of research demonstrating the myriad of favorable physical, psychological, and interpersonal associations with women’s orgasms across relational and sexual contexts. Because orgasm has continually surfaced as such a critical component of women’s positive sexual experiences, we argue the female orgasm should be taken seriously as a meaningful site of research on women’s well-being, and orgasm equality should be taken seriously in the pursuit of gender equality.
Sliding frictional characteristic of tight sandstone and its influence on the hydraulic fracture complexity
Authors: Yan Wei , Wu Tao , Wu Jianshu , Ali Mandella , Li Yang , Cao Han 
Published: August 2023

AbstractThe complexity of the fracture network during hydraulic fracturing is closely related to the frictional characteristics of the reservoir rock, which largely depends on the rock’s mineralogical properties and the type of fracturing fluid. In this study, the micro-friction characteristics of three kinds of tight sandstone were tested using an indoor rock micro-friction setup. The effects of different hydraulic fluids and rock mineralogical properties on the friction coefficient were investigated. A numerical model was then developed to investigate the influence of different friction coefficients on fracture propagation. The results indicate that the friction coefficients of tight sandstones are closely related to their content of clay and quartz. When the content of clay is low (around 20%), the content of hard particles such as quartz and feldspar is high, the friction coefficient of the rock appears to be high and insensitive to the wetting characteristics of the fracturing fluid. Conversely, when the clay content is high (around 30%), rock friction coefficients tend to be sensitive to different types of fracture liquids, and decrease when the liquid wets the rock. The numerical simulation results indicate that a 0.4 friction coefficient produces the maximum of fracture complexity. These findings provide a potential method on how to increase the productivity of unconventional plays by generating complex fracture networks.
Evaluation of a Culturally Adapted Online Basic Psychosocial Skills Training Program for International Frontline Workers in Under-Resourced Contexts During the COVID-19 Pandemic
Authors: Brown Di , River Jo , Sheppard-Law Suzanne , Chang Odille , Obed Jimmy , Townsend Lisa , Iro Elizabeth , Rumsey Michele 
Published: August 2023

Abstract

Objective:
Frontline workers report negative mental health impacts of being exposed to the risk of COVID-19, and of supporting people struggling with the effects of the virus. Uptake of psychological first-aid resources is inconsistent, and they may not meet the needs of frontline workers in under-resourced contexts. This study evaluates a culturally adapted basic psychosocial skills (BPS) training program that aimed to meet the needs of frontline workers in under-resourced settings.

Methods:
A cross-sectional survey administered to frontline workers who completed the program between 2020 and 2022, investigated their perceived confidence, satisfaction, and skill development, as well as their views on relevance to context and accessibility of the program.

Results:
Out of the 1000 people who had undertaken the BPS program, 118 (11.8%) completed the survey. Participants reported high levels of satisfaction and improved confidence in, and knowledge of, psychosocial skills. Participants reported that the BPS program was culturally and contextually relevant, and some requested expansion of the program, including more interactivity, opportunities for anonymous participation, and adaption to other cultural contexts, including translation into languages other than English.

Conclusion:
Findings indicate a need for free, online, and culturally adapted psychosocial skills training program that is designed with key stakeholders to ensure relevance to social and cultural contexts.
In Search of Shelter: Precarity, Protest, and Pronatalism among Laboring Women in Kazakhstan
Authors: Tourtellotte Laura 
Published: August 2023

AbstractIn 2019, near Nur-Sultan, Kazakhstan, five children perished in a house fire while their parents were away at night shift jobs. This widely-reported tragedy brought to light conflicting imperatives and highlighted the precarity of gendered productive and reproductive labor across Kazakhstan. This highly-publicized incident ignited a conflagration of protests by “mothers with many children” (mnogodetnye mamy, kopbala analar), the official designation for low-income women who have four or more children and are eligible for state support. This paper analyzes the mothers’ protests of 2019, and the public and official responses to these protests. It finds that, by centering motherhood and traditional gender norms in their protests, these protestors successfully linked their demands for social benefits back to historic Soviet-era protectionist and paternalist policies, thus legitimizing their demands. However, the article argues that at the same time these gendered labor norms force women, especially marginalized mothers, to engage in precarious forms of labor that neither Western-style NGOs nor limited government support are able to adequately address. The article further concludes that “mothers with many children” labor under precarious conditions and are subject to skepticism and censure, as their actions challenge idealized national scripts of proper womanhood in Kazakhstan. This research contributes to the study of labor, gender, and reproduction in Central Asia and calls for centering the study of gendered labor precarity within Central Asian studies.
Library profile: The Royal Institution of Chartered Surveyors
Authors: Fogden Fiona 
Published: August 2023

AbstractFiona Fogden has spent much of her career in law firm libraries, but she has recently taken on the role of Knowledge & Information Service Manager at RICS – the Royal Institution of Chartered Surveyors. So, who better to give LIM an overview of the RICS Knowledge & Information service, describe what the collections contain, and also tell us how the service would be of interest to legal information professionals.
Getting your ducks in a ROE: understanding and working with the Register of Overseas Entities
Authors: Vickery Barry 
Published: August 2023

AbstractIn this paper, Barry Vickery returns to his legal information background and interviews Sam Lloyd, a Director at CRO Info, who has worked with Companies House for over 40 years and is one of the UK regulated agents authorised to complete verification checks on beneficial owners of overseas entities. Here they discuss the newly incorporated Register of Overseas Entities (ROE), share its brief history to date, the reasons for its introduction, and the challenges and benefits of creating and maintaining it.
A connected legal world – Lexis+ UK
Authors: Algie David 
Published: August 2023

AbstractThe LexisLibrary and LexisPSL legal content platforms are well known to legal information professionals and lawyers in the UK. The release of the Lexis+ UK service seamlessly brings together these resources on one platform for the first time, allowing the researcher to search and retrieve relevant and connected content through one search interface. David Algie, the Lexis+ Product Marketing Manager at LexisNexis, talks LIM readers through this innovative and ‘feature rich’ new product.
The impact of race on survival in metastatic prostate cancer: a systematic literature review
Authors: Freedland Stephen J. , Samjoo Imtiaz A. , Rosta Emily , Lansing Austin , Worthington Evelyn , Niyazov Alexander , Nazari Jonathan , Arondekar Bhakti 
Published: August 2023

Abstract
Background
Prostate cancer (PC) is the second most diagnosed cancer in men worldwide. While racial and ethnic differences exist in incidence and mortality, increasing data suggest outcomes by race among men with newly diagnosed PC are similar. However, outcomes among races beyond Black/White have been poorly studied. Moreover, whether outcomes differ by race among men who all have metastatic PC (mPC) is unclear. This systematic literature review (SLR) provides a comprehensive synthesis of current evidence relating race to survival in mPC.

Methods
An SLR was conducted and reported in accordance with PRISMA guidelines. MEDLINE®, Embase, and Cochrane Library using the Ovid® interface were searched for real-world studies published from January 2012 to July 2022 investigating the impact of race on overall survival (OS) and prostate cancer-specific mortality (PCSM) in patients with mPC. A supplemental search of key congresses was also conducted. Studies were appraised for risk of bias.

Results
Of 3228 unique records identified, 62 records (47 full-text and 15 conference abstracts), corresponding to 54 unique studies (51 United States and 3 ex-United States) reporting on race and survival were included. While most studies showed no difference between Black vs White patients for OS (n = 21/27) or PCSM (n = 8/9), most showed that Black patients demonstrated improved OS on certain mPC treatments (n = 7/10). Most studies found no survival difference between White patients and Hispanic (OS: n = 6/8; PCSM: n = 5/6) or American Indian/Alaskan Native (AI/AN) (OS: n = 2/3; PCSM: n = 5/5). Most studies found Asian patients had improved OS (n = 3/4) and PCSM (n = 6/6) vs White patients.

Conclusions
Most studies found Black, Hispanic, and AI/AN patients with mPC had similar survival as White patients, while Black patients on certain therapies and Asian patients showed improved survival. Future studies are needed to understand what aspects of race including social determinants of health are driving these findings.
An aqueous electrolyte densified by perovskite SrTiO3 enabling high-voltage zinc-ion batteries
Authors: Deng Rongyu , He Zhenjiang , Chu Fulu , Lei Jie , Cheng Yi , Zhou You , Wu Feixiang 
Published: August 2023

AbstractThe conventional weak acidic electrolyte for aqueous zinc-ion batteries breeds many challenges, such as undesirable side reactions, and inhomogeneous zinc dendrite growth, leading to low Coulombic efficiency, low specific capacity, and poor cycle stability. Here, an aqueous densified electrolyte, namely, a conventional aqueous electrolyte with addition of perovskite SrTiO3 powder, is developed to achieve high-performance aqueous zinc-ion batteries. The densified electrolyte demonstrates unique properties of reducing water molecule activity, improving Zn2+ transference number, and inducing homogeneous and preferential deposition of Zn (002). As a result, the densified electrolyte exhibits an ultra-long cycle stability over 1000 cycles in Zn/Ti half cells. In addition, the densified electrolyte enables Zn/MnO2 cells with a high specific capacity of 328.2 mAh g−1 at 1 A g−1 after 500 cycles under an extended voltage range. This work provides a simple strategy to induce dendrite-free deposition characteristics and high performance in high-voltage aqueous zinc-ion batteries.
ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression
Authors: Zhang Suyang , Yang Feng , Huang Yile , He Liangqiang , Li Yuying , Wan Yi Ching Esther , Ding Yingzhe , Chan Kui Ming , Xie Ting , Sun Hao , Wang Huating 
Published: August 2023

AbstractSkeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly understood how SCs enter cell cycle to become activated upon injury. Here we report that AP-1 family member ATF3 (Activating Transcription Factor 3) prevents SC premature activation. Atf3 is rapidly and transiently induced in SCs upon activation. Short-term deletion of Atf3 in SCs accelerates acute injury-induced regeneration, however, its long-term deletion exhausts the SC pool and thus impairs muscle regeneration. The Atf3 loss also provokes SC activation during voluntary exercise and enhances the activation during endurance exercise. Mechanistically, ATF3 directly activates the transcription of Histone 2B genes, whose reduction accelerates nucleosome displacement and gene transcription required for SC activation. Finally, the ATF3-dependent H2B expression also prevents genome instability and replicative senescence in SCs. Therefore, this study has revealed a previously unknown mechanism for preserving the SC population by actively suppressing precocious activation, in which ATF3 is a key regulator.
An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
Authors: Igarashi Taichi , Mazevet Marianne , Yasuhara Takaaki , Yano Kimiyoshi , Mochizuki Akifumi , Nishino Makoto , Yoshida Tatsuya , Yoshida Yukihiro , Takamatsu Nobuhiko , Yoshimi Akihide , Shiraishi Kouya , Horinouchi Hidehito , Kohno Takashi , Hamamoto Ryuji , Adachi Jun , Zou Lee , Shiotani Bunsyo 
Published: August 2023

AbstractActivation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we show that induction of KRASG12V expression in untransformed cells triggers H3K27me3 and HP1-associated chromatin compaction in an RNA transcription dependent manner, resulting in replication fork slowing and cell death. Furthermore, elevated ATR expression is necessary and sufficient for tolerance of KRASG12V-induced replication stress to expand replication stress-tolerant cells (RSTCs). PrimPol is phosphorylated at Ser255, a potential Chk1 substrate site, under KRASG12V-induced replication stress and promotes repriming to maintain fork progression and cell survival in an ATR/Chk1-dependent manner. However, ssDNA gaps are generated at heterochromatin by PrimPol-dependent repriming, leading to genomic instability. These results reveal a role of ATR-PrimPol in enabling precancerous cells to survive KRAS-induced replication stress and expand clonally with accumulation of genomic instability.
The respective activation and silencing of striatal direct and indirect pathway neurons support behavior encoding
Authors: Varin Christophe , Cornil Amandine , Houtteman Delphine , Bonnavion Patricia , de Kerchove d’Exaerde Alban 
Published: August 2023

AbstractThe basal ganglia are known to control actions and modulate movements. Neuronal activity in the two efferent pathways of the dorsal striatum is critical for appropriate behavioral control. Previous evidence has led to divergent conclusions on the respective engagement of both pathways during actions. Using calcium imaging to evaluate how neurons in the direct and indirect pathways encode behaviors during self-paced spontaneous explorations in an open field, we observed that the two striatal pathways exhibit distinct tuning properties. Supervised learning algorithms revealed that direct pathway neurons encode behaviors through their activation, whereas indirect pathway neurons exhibit behavior-specific silencing. These properties remain stable for weeks. Our findings highlight a complementary encoding of behaviors with congruent activations in the direct pathway encoding multiple accessible behaviors in a given context, and in the indirect pathway encoding the suppression of competing behaviors. This model reconciles previous conflicting conclusions on motor encoding in the striatum.
Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome
Authors: Wu Ping Chun , Lee Yan Quan , Möller Mattias , Storry Jill R. , Olsson Martin L. 
Published: August 2023

AbstractGenetic determinants underlying most human blood groups are now clarified but variation in expression levels remains largely unexplored. By developing a bioinformatics pipeline analyzing GATA1/Chromatin immunoprecipitation followed by sequencing (ChIP-seq) datasets, we identify 193 potential regulatory sites in 33 blood-group genes. As proof-of-concept, we aimed to delineate the low-expressing complement receptor 1 (CR1) Helgeson phenotype on erythrocytes, which is correlated with several diseases and protects against severe malaria. We demonstrate that two candidate CR1 enhancer motifs in intron 4 bind GATA1 and drive transcription. Both are functionally abolished by naturally-occurring SNVs. Erythrocyte CR1-mRNA and CR1 levels correlate dose-dependently with genotype of one SNV (rs11117991) in two healthy donor cohorts. Haplotype analysis of rs11117991 with previously proposed markers for Helgeson shows high linkage disequilibrium in Europeans but explains the poor prediction reported for Africans. These data resolve the longstanding debate on the genetic basis of inherited low CR1 and form a systematic starting point to investigate the blood group regulome.
Cell-specific and shared regulatory elements control a multigene locus active in mammary and salivary glands
Authors: Lee Hye Kyung , Willi Michaela , Liu Chengyu , Hennighausen Lothar 
Published: August 2023

AbstractRegulation of high-density loci harboring genes with different cell-specificities remains a puzzle. Here we investigate a locus that evolved through gene duplication and contains eight genes and 20 candidate regulatory elements, including one super-enhancer.Caseingenes (Csn1s1,Csn2,Csn1s2a,Csn1s2b,Csn3) are expressed in mammary glands, induced 10,000-fold during pregnancy and account for 50% of mRNAs during lactation,Prr27andFdcspare salivary-specific andOdamhas dual specificity. We probed the function of 12 candidate regulatory elements, individually and in combination, in the mouse genome. The super-enhancer is essential for the expression ofCsn3, Csn1s2b,OdamandFdcspbut largely dispensable forCsn1s1,Csn2andCsn1s2a.Csn3activation also requires its own local enhancer. Synergism between local enhancers and cytokine-responsive promoter elements facilitates activation ofCsn2during pregnancy. Our work identifies the regulatory complexity of a multigene locus with an ancestral super-enhancer active in mammary and salivary tissue and local enhancers and promoter elements unique to mammary tissue.
Predictive signs and symptoms of bacterial meningitis isolates in Northern Ghana
Authors: Weyori Enoch Weikem , Abubakari Braimah Baba , Nkrumah Bernard , Abdul-Karim Abass , Abiwu Hilarius Asiwome Kosi , Kuugbee Eugene Dogkotenge , Yidana Adadow , Ziblim Shamsu-Deen , Nuertey Benjamin , Weyori Benjamin Asubam , Yakubu Etowi Boye , Azure Stebleson , Koyiri Valentine Cheba , Adatsi Richard Kujo 
Published: August 2023

AbstractCerebrospinal meningitis (CSM) is a public health burden in Ghana that causes up to 10% mortality in confirmed cases annually. About 20% of those who survive the infection suffer permanent sequelae. The study sought to understand the predictive signs and symptoms of bacterial meningitis implicated in its outcomes. Retrospective data from the Public Health Division, Ghana Health Service on bacterial meningitis from 2015 to 2019 was used for this study. A pre-tested data extraction form was used to collect patients’ information from case-based forms kept at the Disease Control Unit from 2015 to 2019. Data were transcribed from the case-based forms into a pre-designed Microsoft Excel template. The data was cleaned and imported into SPSS version 26 for analysis. Between 2015 and 2019, a total of 2446 suspected bacterial meningitis cases were included in the study. Out of these, 842 (34.4%) were confirmed. Among the confirmed cases, males constituted majority with 55.3% of the cases. Children below 14 years of age were most affected (51.4%). The pathogens commonly responsible for bacterial meningitis were Neisseria meningitidis (43.7%) and Streptococcus pneumoniae (53.0%) with their respective strains Nm W135 (36.7%), Nm X (5.1%), Spn St. 1 (26.2%), and Spn St. 12F/12A/12B/44/4 (5.3%) accounting for more than 70.0% of the confirmed cases. The presence of neck stiffness (AOR = 1.244; C.I 1.026–1.508), convulsion (AOR = 1.338; C.I 1.083–1.652), altered consciousness (AOR = 1.516; C.I 1.225–1.876), and abdominal pains (AOR = 1.404; C.I 1.011–1.949) or any of these signs and symptoms poses a higher risk for testing positive for bacterial meningitis adjusting for age. Patients presenting one and/or more of these signs and symptoms (neck stiffness, convulsion, altered consciousness, and abdominal pain) have a higher risk of testing positive for bacterial meningitis after statistically adjusting for age.
Autologe und allogene Serumaugentropfen (SAT) beim schweren
Sicca-Syndrom
Authors: Wurlitzer Grit , Sievert Uwe 
Published: August 2023

ZusammenfassungBeim schweren Sicca-Syndrom haben sich zur Linderung der Symptome und zur
Förderung der Heilung autologe Serum-Augentropfen (SAT) bewährt.
Für Patienten, die nicht spenden können, stellt der
DRK-Blutspendedienst Chemnitz seit 2021 auch allogene SAT her. In Bezug auf
Wirksamkeit und Verträglichkeit sind allogene SAT den autologen
Präparaten ebenbürtig. Bei beiden ist die richtige Indikation
entscheidend für eine erfolgreiche Therapie.SAT können in einem relativ einfachen Verfahren hergestellt werden.
Allerdings ist der gesamte Arbeitsablauf – von der Verschreibung durch
den Augenarzt bis zum Zeitpunkt, an dem der Patient die Augentropfen
erhält – komplex. Sowohl für den Hersteller als auch
für die oft sehbehinderten Patienten gibt es viele Hürden zu
überwinden. Anwendung, Blutspende, Abgabe, Herstellung und Lieferung
müssen gut aufeinander abgestimmt sein, damit am Ende für alle
Beteiligten hervorragende Ergebnisse erzielt werden können.