bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway
by Antagonizing TGF-β in Giant Cell Tumor of Bone
Authors: Xu Tangbing , Xu Shenglin , Ma Guangwen , Chang Jun , Zhang Chi , Zhou Ping , Wang Chao , Xu Pengfei , Yang Junjun , Hu Yong , Wu Yunfeng 
Published: April 2023

Background:
Giant cell tumor of bone (GCTB) is a locally aggressive bone tumour
aggravated by stromal cell proliferation and metastasis.

Objective:
We investigated the mechanism of action of human chorionic gonadotropin (HCG) in
mediating GCTB proliferation and invasion.

Methods:
The expression of HCG was quantified using quantitative real-time PCR. After the primary
stromal cells were isolated and identified, the function of HCG in GCTB was estimated using
the cell counting kit-8, flow cytometry, scratch experiment, transwell assay, Western blot, and
immunofluorescence. Moreover, the mechanism of HCG was assessed through western blotting.

Results:
HCG expression was decreased in clinical tissue samples from patients with GCTB. We
validated that HCG repressed stromal cell proliferation, migration, invasion, autophagy, and epithelial-
mesenchymal transition (EMT) and promoted cell apoptosis in GCTB. We also verified
that HCG repressed the autophagy and EMT of stromal cells through the Smad signaling axis in
GCTB. HCG inhibited the transduction of the Smad signaling pathway by restraining the binding
of the TGF-β II receptor to ligand Activin A.

Conclusion:
HCG restrained the Smad signaling pathway by antagonizing TGF-β signaling in GCTB. HCG may serve as a useful patent to treat GCTB.
Advances in Peptide/Protein Structure Prediction Tools and their Relevance
for Structural Biology in the Last Decade
Authors: Rezende Samilla B. , Lima Lucas R. , Macedo Maria L. R. , Franco Octávio L. , Cardoso Marlon H. 
Published: April 2023

Abstract:
Peptides and proteins are involved in several biological processes at a molecular level. In this
context, three-dimensional structure characterization and determination of peptides and proteins have
helped researchers unravel the chemical and biological role of these macromolecules. Over 50 years,
peptide and protein structures have been determined by experimental methods, including nuclear magnetic
resonance (NMR), X-ray crystallography, and cryo-electron microscopy (cryo-EM). Therefore, an
increasing number of atomic coordinates for peptides and proteins have been deposited in public databases,
thus assisting the development of computational tools for predicting unknown 3D structures. In
the last decade, a race for innovative methods has arisen in computational sciences, including more
complex biological activity and structure prediction algorithms. As a result, peptide/protein theoretical
models have achieved a new level of structure prediction accuracy compared with experimentally determined
structures. Machine learning and deep learning approaches, for instance, incorporate fundamental
aspects of peptide/protein geometry and include physical/biological knowledge about these macromolecules'
experimental structures to build more precise computational models. Additionally, computational
strategies have helped structural biology, including comparative, threading, and ab initio modeling
and, more recently, prediction tools based on machine learning and deep learning. Bearing this in
mind, here we provide a retrospective of protein and peptide structure prediction tools, highlighting
their advances and obstacles and how they have assisted researchers in answering crucial biological
questions.
Antimicrobial Efficacy of Various Nanoparticles on Addition to Orthodontic
Materials- A Systematic Review and Meta-Analysis
Authors: Kumari Deesha , Runa Soans Crystal , Shersha Shalin , Mansoor Rahila , Ravi M.S. 
Published: April 2023

Aim:
The purpose of this study is to examine the evidence for the efficiency of nanoparticles
(NPs) incorporated into orthodontic materials (brackets, bonding agents, wires, acrylic resin, and elastics)
in order to enhance their antimicrobial properties.

Materials and Methods:
A comprehensive search strategy was conducted in electronic databases like
PubMed, Cochrane, and Google scholar, books, grey literature like unpublished literature, dissertations,
conference reports, etc. Finally, out of all the literature reviewed, a total of 30 articles met the inclusion
criteria and were included in the qualitative analysis. For the quantitative analysis, a total of 6 articles
were used.

Results:
Antimicrobial agents such as silver nanoparticles, Titanium dioxide, Silver platinum alloy, zinc
oxide and copper oxide, quaternary ammonium dimethacrylate (QADM), Hydroxyapatite crystals, and
silver, quaternary ammonium polyethyleneimine (QPEI) particles, silica, and titanium have been incorporated
in various orthodontic materials. The incorporation of these nanoparticles into orthodontic materials
led to a significant increase in the antibacterial capacity when compared to controls used in the various
studies.

Conclusion:
It can be concluded that the incorporation of nanoparticles into orthodontic materials
improves their antibacterial properties. Due to the heterogeneity observed across the studies reviewed,
further research with standardized study protocols in terms of the size, concentration, and techniques of
incorporation of different NPs into various orthodontic materials is pertinent.
Antimicrobial peptides for treatment of patients with herpes virus-associated chronic prostatitis
Authors: Kulchavenya E. V. , Shevchenko S. Yu. , Baranchukova A. A. 
Published: April 2023

Introduction. Genital herpes is a chronic sexually transmitted infection characterised by recurrent self-limiting genital ulcers caused by herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2) and can be associated with chronic prostatitis (CP).Objective. To determine the efficacy of cytokines-antimicrobial peptides complex in therapy of patients with herpes virus-associated chronic prostatitis.Materials & methods. The pilot, open, prospective, non-comparative study included 23 patients who were followed up for CP for a mean of 9.7 ± 4.2 years. All were diagnosed with abacterial CP / chronic pelvic pain syndrome (CPPS) with signs of inflammation and detection of HSV DNA in urethral swabs by polymerase chain reaction (PCR). Prescribed therapy: Tab. Valaciclovir 500 mg b.i.d. p.o. for 10 days, Tab. Ketoprofen 100 mg q.d. for 5 days, Supp. Superlymph 10 IU q.d. p.r. q.h.s. for 20 days. The results were evaluated at the end of therapy, 3 and 6 months after its completion.Results. At the end of therapy, the leukocytes count in prostate secretion decreased by almost five times and remained stable throughout the entire follow-up period. The total symptom scale score at the end of therapy decreased from 22.96 ± 6.01 to 6.61 ± 3.71 points (p < 0.05). There was also a change in the perception of pain on a visual analog scale. If, before the start of treatment, 14 patients (60.9%) assessed the pain intensity as “severe” and only two (8.7%) had “weak” pain intensity, then after the end of therapy, none of the patients had severe pain, 21 (91.3%) patients noted "mild" pain and in 2 patients (8.7%) the intensity of pain was regarded as "average". Quality of life improved from baseline 8.23 ± 1.91 points to 2.43 ± 1.41 points immediately after completion of therapy (p < 0.05). Three months after therapy, patients assessed the quality of life as 2.43 ± 1.41 points, and six months later, as 2.81 ± 1.21 points. During the first three months, one patient experienced a HPV-relapse; one more — within the next three months. These patients underwent a second course according to a similar scheme. None of the patients reported significant side effects on any component of the therapeutic complex.Conclusion. In abacterial CP/CPPS, a herpes infection should be identified. Being neurotropic, HSV can cause / exacerbate the pain characteristic of CP/CPPS. In case of persistent pain, HSV infection should be excluded. In the treatment of patients with herpes virus-associated abacterial CP, Supp. Superlymph showed good immediate and long-term results.
Evaluation of an Innovative Colon Capsule Endoscopy Service in Scotland From the Perspective of Patients: Mixed Methods Study
Authors: Bond Sarah , Kyfonidis Charalampos , Jamieson Matthew , Maguire Roma , McCann Lisa , Watson Angus , Brogan Michelle , Lennon Marilyn 
Published: April 2023

Background
Colonoscopy is the gold standard for lower gastrointestinal diagnostics. The procedure is invasive, and its demand is high, resulting in long waiting times. Colon capsule endoscopy (CCE) is a procedure that uses a video capsule to investigate the colon, meaning that it can be carried out in a person’s own home. This type of “hospital-at-home” service could potentially reduce costs and waiting times, and increase patient satisfaction. Little is currently understood, however, about how CCE is actually experienced and accepted by patients.

Objective
The aim of this study was to capture and report patient experiences of the CCE technology (the capsule and associated belt and recorder) and of the new clinical pathway for the CCE service being rolled out as part of routine service in Scotland.

Methods
This was a mixed methods service evaluation of patient experiences of a real-world, deployed, managed service for CCE in Scotland. Two hundred and nine patients provided feedback via a survey about their experiences of the CCE service. Eighteen of these patients took part in a further telephone interview to capture more in-depth lived experiences to understand the barriers and opportunities for the further adoption and scaling up of the CCE service in a way that supports the patient experience and journey.

Results
Patients overall perceived the CCE service to be of significant value (eg, mentioning reduced travel times, reduced waiting times, and freedom to complete the procedure at home as perceived benefits). Our findings also highlighted the importance of clear and accessible information (eg, what to expect and how to undertake the bowel preparation) and the need for managing expectations of patients (eg, being clear about when results will be received and what happens if a further colonoscopy is required).

Conclusions
The findings led to recommendations for future implementations of managed CCE services in National Health Service (NHS) Scotland that could also apply more widely (United Kingdom and beyond) and at a greater scale (with more patients in more contexts). These include promoting CCE with, for, and among clinical teams to ensure adoption and success; capturing and understanding reasons why patients do and do not opt for CCE; providing clear information in a variety of appropriate ways to patients (eg, around the importance of bowel preparation instructions); improving the bowel preparation (this is not specific to CCE alone); providing flexible options for issuing and returning the kit (eg, dropping off at a pharmacy); and embedding formative evaluation within the service itself (eg, capturing patient-reported experiences via surveys in the information pack when the equipment is returned).
Aproximación a la estructura económica de la Región del Bío-Bío en base a aplicaciones insumos producto, para el año 2006 y base 2003
Authors: Pino Arriagada Osvaldo , Parra Márquez Juan Carlos 
Published: April 2023

En este artículo, a partir de una Matriz Insumo- Producto Regional (MIPR) actualizada y la utilización del enfoques de análisis estructural de Rasmussen (1958), se realiza un análisis comparativo de los índices de Poder de Dispersión y Sensibilidad de Dispersión, conceptos que permiten cuantificar la naturaleza de los eslabonamientos sectoriales, hacia delante y hacia atrás (forward and backward linkages) para el periodo 1998-2006.Se describe la metodología y método RAS de actualización de las respectivas tablas input-ouput (40x40 sectores); A partir de la nueva matriz inversa de la VIII Región del Bío Bío de 40*40 sectores se procede a presentar y estimar los conocidos índices de poder y de sensibilidad de dispersión.Posteriormente se caracterizan estas actividades en sectores claves, estratégicos, impulsores, islas. La presentación de los resultados se realiza sobre la base de un conjunto de tablas; que persiguen entregar una visión de los eslabonamientos intersectoriales de las actividades gravitatorias de la economía regional. AbstractIn this paper, based on an updated regional input-output matrix (MIPR) and Rasmussen’s structural analysis approach, we present a comparative analysis for the power of dispersion and sensitivity of dispersion indices, which enable us to quantify the nature of the backward and forward linkages for the period 1998-2006.Using the RAS methodology and starting from a new inverse matrix for the Bio Bio region, which considers 40x40 productive sectors, we present and estimate the power of dispersion and sensitivity of dispersion indices.Finally, we classify the above economic sectors as key, strategic, driver, or island. The results are shown in several tables, which pretend to present the productive linkages between the main economic activities of the regional economy.
Análisis y evaluación crítica del rol desempeñado por la organización internacional del trabajo (OIT) en desarrollar y asegurar principios y derechos fundamentales en el trabajo
Authors: López Bohle Sergio , Ugarte Gómez Sebastián 
Published: April 2023

Este artículo analiza el rol y misión de la OIT en promover los principios fundamentales en el trabajo (PFT) y monitorear su cumplimiento. También hace una evaluación crítica de la efectividad de los métodos empleados por la ILO para asegurar los PFT, en un complejo contexto de diferentes grados de desarrollo social y económico, ideologías políticas, así como tener que lidiar en algunas ocasiones con propósitos divergentes de sus actores sociales (empleadores, trabajadores y gobiernos). El artículo discute los principales debates y problemas enfrentados por la OIT al momento de interactuar con la diversa gama de Estados miembros. Finalmente, son propuestas algunas observaciones con el objetivo de mejorar la aplicación de los PFT en vista de los nuevos desafíos sociales y económicos del mundo actual. AbstractThis paper analyses the role and mission of the ILO in promoting core labour standards (CLS) and monitoring its compliance. It also makes a critical assessment to the effectiveness of the methods employed by the ILO to secure the CLS, in a complex context of different degrees of social and economic development, political ideologies, as well as dealing in some occasions with divergent purposes of its social actors (employers, workers and governments). The article discusses the main debates and issues faced by the ILO when interacting with its diverse range of member States. Finally, some fi nal remarks are proposed with the objective to improve the application of the CLS to the new social and economic challenges of today’s world.
El rol moderador de la flexibilidad del horario de trabajo en la relación del enriquecimiento trabajo familia y la satisfacción docente
Authors: Jijena-Michel Robert Daniel , Jijena Michel Carlos Eduardo 
Published: April 2023

El propósito de esta investigación es analizar la relación entre el enriquecimiento trabajofamilia y la satisfacción laboral docente; como también el efecto moderador de la flexibilidad del horario de trabajo en dicha relación. El enriquecimiento trabajo-familia se refiere a la forma en que el trabajo y la familia se benefician entre sí, y es bidireccional: trabajo-familia y familia-trabajo. Se recogió información primaria por medio de cuestionarios aplicados a docentes universitarios de la Facultad de Ciencias Económicas y Financieras de la Universidad Autónoma Juan Misael Saracho (Tarija, Bolivia). Los resultados reflejan que el enriquecimiento trabajo-familia influye de manera positiva en la satisfacción laboral, mientras que el enriquecimiento familia-trabajo no. Además, la flexibilidad del horario presenta un efecto moderador significativo sobre la relación enriquecimiento trabajo-familia y satisfacción. Es más, dicho efecto moderador provoca que el enriquecimiento familia-trabajo se vuelva significativo para la satisfacción. Estos hallazgos se convierten en insumos útiles para el diseño e implementación de políticas en conciliación trabajo-vida y prácticas de trabajo flexible, con el fin de mejorar la satisfacción del profesorado y consecuentemente, su compromiso organizacional. AbstractThis paper aims to analyze the relationship between work-family enrichment and faculty job satisfaction, and also the moderating effect of job schedule flexibility on the stated relation. Workfamily enrichment refers to how work and family benefit each other, and it’s bidirectional: workfamily and family-work. Data were collected through surveys applied to university professors from Economics and Finance Faculty of Juan Misael Saracho Autonomous University (Tarija, Bolivia). Results show that work-family enrichment is positively related with job satisfaction, while family-work enrichment is not. Furthermore, job schedule flexibility has a moderating effect on the relationship between work-family enrichment and job satisfaction. Moreover, the moderating effect causes that family-work enrichment becomes significant for satisfaction. These findings could be helpful inputs to design and implement policies concerning to work-family balance and work flexible practices, in order to improve faculty satisfaction and consequently, their organizational commitment.
Impactos y consecuencias en el sector azucarero en Colombia a partir del TLC con la Unión Europea
Authors: Espinosa Acuña Óscar Andrés , Vaca González Paola Andrea 
Published: April 2023

La presente investigación tiene por finalidad analizar el impacto en Colombia del tratado de libre comercio con la Unión Europea, respecto a la dinámica del sector azucarero en Colombia, como producto de consumo interno y de exportación. Se analizan los aspectos de producción, competitividad y posibles cambios estructurales que se puedan presentar sobre este sector frente a los nuevos retos contemplados en el mercado mundial. Para ello se estima un sistema de ecuación de oferta y un modelo VAR-X, utilizando la información mensual de enero de 2000 a febrero de 2012, reportada por Asocaña y la FAO. Se concluye que el sector se encuentra apto para responder ante el acuerdo comercial, y representaría beneficios económicos importantes para la nación. AbstractThis research aims to analyze the impact on Colombia of the Free Trade Agreement with the European Union, regarding the dynamics of the sugar sector in Colombia, both as a product of domestic consumption and export. It discusses the aspects of production, competitiveness and possible structural changes that may occur on this sector regarding the new challenges set out in the world market. To do this, it is estimated a supply equation system and a model VAR-X, using monthly data from January 2000 to February 2012, reported by Asocaña and FAO. It is concluded that industry is able to respond to the trade agreement, and represent significant economic benefits for the nation.
Conmutación interregional, una mirada desde la VIII Región del Bío-Bío ( NENE año 2012)
Authors: Pino A. Osvaldo , Concha M. Gary 
Published: April 2023

El estudio realiza un procesamiento y análisis de la información de las principales dimensiones y características de la movilidad residencia-trabajo contenida en la NENE de 2012 para la Región del Biobío (VIII). Mediante un modelo de autonomía de oferta y demanda, en un enfoque sincrónico, se presenta el estado de la variable conmutación desde la perspectiva de género, la componente etaria y otras características socio-profesionales (CIIU - CIOU). Se demuestra que la región se presenta como oferente neto de conmutantes masculinos y se cuantifica el impacto económico de este proceso. AbstractThe study takes a processing and data analysis of the main dimensions and characteristics of mobility residence-work contained in the NENE 2012 to the Biobío Region (VIII). Using a model of autonomy of supply and demand in a synchronous approach, the state of the commutation variable from the perspective of gender, age component and other socio-professional (CIIU-CIOU) is presented. We show that the region is presented as net supplier of male commuters and economic impact of this process is quantified.
Estudio empírico de calidad de vida laboral, cuatro indicadores: Satisfacción laboral, condiciones y medioambiente del trabajo, organización e indicador global, sectores privado y público. Desarrollo, aplicación y validación del instrumento
Authors: Chiang Vega Dra. María Margarita , Krausse Martínez Karina Ayres 
Published: April 2023

La investigación tiene por objeto elaborar un instrumento para conocer la calidad de vida laboral de la empresa. La muestra de este estudio corresponde a 128 trabajadores de los sectores privado y público.El instrumento de medición aplicado para la calidad de vida laboral consta de 118 ítems divididos en 4 indicadores: satisfacción laboral, condiciones y medioambiente del trabajo, organización e indicadores globales.Se puede concluir que las escalas, están validadas para esta muestra y pueden ser utilizadas para medir la calidad de vida laboral de empresas privadas y de instituciones estatales y con ello ayudar a mejorar y corregir las estrategias con que operan las empresas u organizaciones tanto a sus grupos de interés internos como externos (stakeholders). AbstractThis research intends to elaborate an instrument to know the quality of labor life of the company. The sample of this study corresponds to 128 workers from private and public sectors.The measuring instrument applied for the quality of labor life consists of 118 items divided in 4 indicators: labor satisfaction, conditions and global environment of the work, organization and indicators.It is possible to be concluded that the scales, are validated for this sample and can be used to measure the quality of labor life of private companies and state institutions and with it to help to improve and to correct the strategies whereupon they as much operate the companies or organizations to its internal groups of interest and external (stakeholders) as well.