bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between academic performance indicators and lifestyle behaviors among Kuwaiti college students
Authors: Al-Haifi Ahmad R. , Al-Awadhi Balqees A. , Bumaryoum Nayef Y. , Alajmi Fahhad A. , Ashkanani Rasha H. , Al-Hazzaa Hazzaa M. 
Published: April 2023

AbstractBackgroundLifestyle behaviors are developed during young adulthood and carried through life. Accordingly, early detection of unhealthy behaviors can help prevent the increase in non-communicable diseases in the population. College students are an especially vulnerable group who, upon entering a new environment, tend to engage in unhealthy behaviors.ObjectiveThe present study aims to evaluate the lifestyle behaviors of Kuwaiti college students and their association with markers of academic achievements.MethodsOne thousand two hundred fifty-nine students participated in the present study and answered an online questionnaire pertaining to their sociodemographic status, academic performance indicators, body weight and height, and lifestyle behaviors. Data were collected from November 2020 to February 2021.ResultsResults of the present study showed that obesity was significantly more prevalent among male participants than among females even though males were more physically active. Alternatively, females had a greater grade point average in college, slept more, and had more screen time. Interestingly, we were unable to detect a significant correlation between lifestyle behaviors and academic achievements.ConclusionThe observed differences in body mass index between genders may have been attributed to energy intake rather than energy expenditure.
Strategies to stabilize dalbavancin in aqueous solutions: Section 4—identification of heat degradation products in 2-hydroxypropyl-β-cyclodextrin and divalent metal ion solutions at pH 4.5 and 7.0
Authors: Jakaria Sardar M. , Budil David E. , Murtagh James 
Published: April 2023

AbstractHeat stress studies have been conducted in support of developing a heat-stable liquid solution of dalbavancin. The degradation products that form in heat-stressed buffered dalbavancin solutions have been identified, including the known major degradation product, mannosyl aglycone (MAG), and four previously uncharacterized compounds. Liquid chromatography-mass spectrometry/mass spectrometry (LC–MS/MS) was used to identify the degradation products of dalbavancin in acetate- and phosphate-buffered solutions under thermal stress at 70 °C and the changes in the degradation pattern in the presence of 2HPβCD and divalent metal ions. Although Ca2+, Mg2+, and Zn2+ did not reduce dalbavancin degradation under thermal stress in acetate buffer, 2HPβCD significantly reduced its overall degradation, in particular, the formation of MAG. This protective effect was enhanced by the addition of Ca2+ to the formulation. In phosphate buffer, MAG formation was also reduced by the addition of 2HPβCD, although significant increases in other degradation products were observed in this case. The addition of Mg2+ to 2HPβCD significantly reduced the overall degradation while increasing MAG formation somewhat. The results strongly suggest that 2HPβCD forms a complex with the hydrophobic glycone tail of dalbavancin, suppressing hydrolysis of the glycosidic bond.
Emerging hallmark of gliomas microenvironment in evading immunity: a basic concept
Authors: Arifianto Muhammad Reza , Meizikri Rizki , Haq Irwan Barlian Immadoel , Susilo Rahadian Indarto , Wahyuhadi Joni , Hermanto Yulius , Faried Ahmad 
Published: April 2023

Abstract
Background
Over the last decade, since clinical trials examining targeted therapeutics for gliomas have failed to demonstrate a meaningful increase in survival, the emphasis has recently been switched toward innovative techniques for modulating the immune response against tumors and their microenvironments (TME). Cancerous cells have eleven hallmarks which make it distinct from normal ones, among which is immune evasion. Immune evasion in glioblastoma helps it evade various treatment modalities.

Summary
Glioblastoma’s TME is composed of various array of cellular actors, ranging from peripherally derived immune cells to a variety of organ-resident specialized cell types. For example, the blood–brain barrier (BBB) serves as a selective barrier between the systemic circulation and the brain, which effectively separates it from other tissues. It is capable of blocking around 98% of molecules that transport different medications to the target tumor.

Objectives
The purpose of this paper is to offer a concise overview of fundamental immunology and how ‘clever’ gliomas avoid the immune system despite the discovery of immunotherapy for glioma.

Conclusions
Herein, we highlight the complex interplay of the tumor, the TME, and the nearby normal structures makes it difficult to grasp how to approach the tumor itself. Numerous researchers have found that the brain TME is a critical regulator of glioma growth and treatment efficacy.
Brief periods of transcutaneous auricular vagus nerve stimulation improve autonomic balance and alter circulating monocytes and endothelial cells in patients with metabolic syndrome: a pilot study
Authors: de Moraes Tercio Lemos , Costa Fernando Oliveira , Cabral Danielly Gomes , Fernandes Daniella Marques , Sangaleti Carine Teles , Dalboni Maria Aparecida , Motta e Motta Josiane , de Souza Liliane Appratto , Montano Nicola , Irigoyen Maria Claudia , Brines Michael , J. Tracey Kevin , Pavlov Valentin A. , Consolim Colombo Fernanda M. 
Published: April 2023

Abstract
Background
There is emerging evidence that the nervous system regulates immune and metabolic alterations mediating Metabolic syndrome (MetS) pathogenesis via the vagus nerve. This study evaluated the effects of transcutaneous auricular vagus nerve stimulation (TAVNS) on key cardiovascular and inflammatory components of MetS.

Methods
We conducted an open label, randomized (2:1), two-arm, parallel-group controlled trial in MetS patients. Subjects in the treatment group (n = 20) received 30 min of TAVNS with a NEMOS® device placed on the cymba conchae of the left ear, once weekly. Patients in the control group (n = 10) received no stimulation. Hemodynamic, heart rate variability (HRV), biochemical parameters, and monocytes, progenitor endothelial cells, circulating endothelial cells, and endothelial micro particles were evaluated at randomization, after the first TAVNS treatment, and again after 8 weeks of follow-up.

Results
An improvement in sympathovagal balance (HRV analysis) was observed after the first TAVNS session. Only patients treated with TAVNS for 8 weeks had a significant decrease in office BP and HR, a further improvement in sympathovagal balance, with a shift of circulating monocytes towards an anti-inflammatory phenotype and endothelial cells to a reparative vascular profile.

Conclusion
These results are of interest for further study of TAVNS as treatment of MetS.
Genome-wide association study for single nucleotide polymorphism associated with mural and cumulus granulosa cells of PCOS (polycystic ovary syndrome) and non-PCOS patients
Authors: Pant Pankaj , Chitme Havagiray , Sircar Reema , Prasad Ritu , Prasad Hari Om 
Published: April 2023

Abstract
Background
The genetic make-up of local granulosa cells and their function in the pathophysiology of polycystic ovary syndrome (PCOS) is crucial to a full comprehension of the disorder. The major purpose of this study was to compare the Single Nucleotide Polymorphism (SNP) of cumulus granulosa cells (CGCs) and mural granulosa cells (MGCs) between healthy individuals and women with PCOS using genome-wide association analysis (GWA). A case–control study was conducted in a total of 24 women diagnosed with PCOS and 24 healthy non-PCOS women of reproductive age aggregated into 4 samples of 6 patients each. GWA studies entail several processes, such as cell separation, cellular DNA extraction, library preparation followed by interpretation using bioinformatics databases. SNP locations were identified by reference gene also involves the use of Matrix-assisted laser desorption/ionisation-time of flight (MALDI-TOF) mass spectrometry (MS) (MALDI-TOF-MS) for the first sorting. Hybridization with the gene chip was followed by reading the SNP genotypes according to the publications in the literature. TASSEL (Trait Analysis by aSSociation, Evolution and Linkage) program and methods were used for GWA studies.

Results
An aggregate of 21,039 SNP calls were obtained from our samples. Genes of autoimmune illnesses, obesity, inflammatory illnesses, nervous system diseases such as retinitis pigmentosa, autism, neural tube defects, and Alzheimer's disease; and various malignancies such as lung cancer, colorectal cancer, breast cancer were also identified in these cells. Gene ranking score reveals that granulosa cells carry key genes of neurological system and reproductive systems especially in brain and testis, respectively.

Conclusions
Mural and Cumulus Granulosa cells were shown to have the PCOS directly and indirectly related genes MMP9, PRKAA2, COMT and HP. We found that the expression of ARID4B, MUC5AC, NID2, CREBBP, GNB1, KIF2C, COL18A1, and HNRNPC by these cells may contribute to PCOS.

Graphical abstract
Response to correspondence article on the research protocol titled Towards Health Equity and Transformative Action on tribal health (THETA) study to describe, explain and act on tribal health inequities in India: A health systems research study protocol
Authors: N Srinivas Prashanth , Seshadri Tanya , Velho Nandini , Babu Giridhar R , Madegowda C , Channabasappa Yogish , Majigi Sumanth Mallikarjuna , Bhat Deepa 
Published: April 2023

In this correspondence, we, co-authors and collaborators involved in the Towards Health Equity and Transformative Action on tribal health (THETA) study respond to a recent article published in Wellcome Open Research titled Correspondence article on the research protocol titled ‘Towards Health Equity and Transformative Action on tribal health (THETA) study to describe, explain and act on tribal health inequities in India: A health systems research study protocol’ published in Wellcome Open Research in December 2019 In the first part, we provide overall clarifications on the THETA study and in the second part respond to specific comments by the authors of the aforementioned correspondence.
Length-weight relationship and condition factor of Hydrocynus forskahlii (Cuvier, 1819) in River Yobe, Northeast, Nigeria
Authors: Segun Ashley-Dejo S. , Ijabo Ogah S. , Yusuf Babdu 
Published: April 2023

This study examined the length-weight relationship and condition factor of Hydrocynus forskahlii (Cuvier, 1819) in River Yobe, Northeast, Nigeria. A total of 350 fish species were collected from commercial fishermen at four landing sites (Gogaram, Dogona, Bize, Azbak) within the study area between June to November 2020. The morphometric and meristic characteristics examined could be attributed to environmental variations (water temperature, stress, food availability, spawning ground, fishing intensity and sex). Monthly mean condition factor (1.19 ± 1.03) shows significant difference (P 0.05) during the sampling duration while highest mean condition factor was recorded in October (1.38 ± 1.15). Also change in weight of the sampled fish was caused by 77.4% change in length. A linear relationship was established with b value (1.2656) indicating a negative allometric growth pattern while correlation coefficient (r2 = 0.7775) indicated that LWR model is reliable. This study bridged literature gap on LWR and condition factor of Hydrocynus forskahlii in River Yobe, hence further research should be encouraged on the water body for sustainable utilization, decision making and policy formulation.
Mg ion implantation and post-annealing effect on the photoelectrical performance of a β-Ga2O3 photodetector
Authors: Wang Zhenghua , Yuan Lei , Wang Yingmin , Wang Jian , Zhang Yuming , Jia Renxu 
Published: April 2023

The effects of magnesium ion implantation and post-annealing on the photoelectric performance of a β-Ga2O3-based vertical structural Schottky photodetector (PD) were thoroughly investigated. After implantation and post-annealing, the Schottky barrier height and bandgap of the Ga2O3 surface can be slightly increased, while the dark current is significantly reduced, and the light-to-dark current ratio is immensely improved. The PD exhibited a photo-to-dark current ratio of 1733, responsivity of 5.04 mA/W, and specific detectivity of 3.979×1011 Jones under −2.6V bias, and the rise and decay times are 0.157 were 0.048 s, respectively. The large left shift of the open-circuit voltage is feasibly explained by applying the thermionic-emission diffusion theory.
The impact of incorporating surgical simulation into trichiasis surgery training on operative aspects of initial live-training surgeries
Authors: Gower Emily W. , Kello Amir B. , Kollmann KH Martin , Merbs Shannath L. , Sisay Alemayehu , Tadesse Demissie , Alemayehu Wondu , Pedlingham Nigel , Dykstra Richard S. , Johnson James E. 
Published: April 2023

Background
While surgical simulation is regularly used in surgical training in high-income country settings, it is uncommon in low- and middle-income countries, particularly for surgical training that primarily occurs in rural areas. We designed and evaluated a novel surgical simulator for improving trachomatous trichiasis (TT) surgery training, given that trichiasis is mostly found among the poorest individuals in rural areas.

Methodology/Principal findings
TT surgery programs were invited to incorporate surgical simulation with a new, high fidelity, low-cost simulator into their training. Trainees completed standard TT-surgery training following World Health Organization guidelines. A subset of trainees received three hours of supplemental training with the simulator between classroom and live-surgery training. We recorded the time required to complete each surgery and the number of times the trainer intervened to correct surgical steps. Participants completed questionnaires regarding their perceptions. We also assessed trainer and trainee perceptions of surgical simulation training as part of trichiasis surgery training.
22 surgeons completed standard training and 26 completed standard training plus simulation. We observed 1,394 live-training surgeries. Average time to first live-training surgery completion was nearly 20% shorter the simulation versus the standard group (28.3 vs 34.4 minutes; p = 0.02). Trainers intervened significantly fewer times during initial live-training surgeries in the simulation group (2.7 vs. 4.8; p = 0.005). All trainers indicated the simulator significantly improved training by allowing trainees to practice safely and to identify problem areas before performing live-training surgeries. Trainees reported that simulation practice improved their confidence and skills prior to performing live-training surgeries.

Conclusions
A single high-fidelity surgical simulation session can significantly improve critical aspects of initial TT surgeries.
Analysis of stereopsis and fusion in school-aged children with reduced visual acuity due to refractive error
Authors: Joo Hye Jun , Choi Dong Gyu 
Published: April 2023

Purpose
In patients with strabismus, the stereopsis and Worth 4-dot (W4d) tests have often been used to evaluate whether sensory fusion is achieved. However, if patients face difficulties undergoing the Titmus or W4d test because of poor visual acuity (VA) due to refractive error abnormalities, the results of these tests cannot be appropriately interpreted. Therefore, we evaluated the correlation between distance uncorrected VA (UCVA) and sensory status in children with reduced VA due to refractive error abnormalities to identify the effects of refractive errors on sensory test results.

Methods
We retrospectively reviewed the medical records of 195 children with reduced VA with VA improvement ≥ 20/25, Titmus stereoacuity ≤ 50 arcsec, and fusion in the W4d result after refractive error correction with spectacles. We evaluated the correlation between distance UCVA in logMAR and sensory status measured by the near Titmus stereotest and distance W4d test. Additionally, the minimum required UCVA for interpreting Titmus or W4d results was assessed using a receiver operating characteristic (ROC) curve.

Results
The UCVA showed a marginal but non-significant correlation with Titmus stereoacuity (p = 0.053) and a significant correlation with fusion in W4d (p < 0.001). The ROC curve analysis showed an optimal cut-point value of VA required for interpreting the results of W4d test as 0.3 logMAR (20/40 in Snellen acuity).

Conclusions
Correcting refractive error in advance may help appropriately interpret sensory status in school-aged children with reduced VA due to refractive error abnormalities.
Knowledge Management and Blockchain Technology for Organizational Sustainability
Authors: Frozza Talita , Lima Edson Pinheiro de , Costa Sérgio Eduardo Gouvêa da 
Published: April 2023

Goal: This paper develops a conceptual model representing existing relations between blockchain, knowledge management, and sustainability.
Design/Methodology/Approach: A systematic literature review was carried out, and a total portfolio of 43 articles was obtained. These articles were then analyzed using the content analysis technique.
Results: Identifying the existing relationships between blockchain and knowledge management and between knowledge management and sustainability was possible. This information allowed the elaboration of the conceptual model, which resulted in the identification of the roles of each theme when related to each other.
Limitations of the investigation: The limitations refer to the diversity and complexity of the themes, which made it necessary to limit the search for articles to two databases; the temporality of the research due to the evolution of the blockchain; and the failure to consider the risks arising from the adoption of technology and the negative aspects of the relationships between the themes.
Practical Implications: With this article, companies studying blockchain adoption, looking for ways to improve knowledge management, or seeking to adjust their impacts on sustainability, can find information that helps in decision making.
Originality/ Value: This article proposes a conceptual model that explains the relationship between three current and increasingly essential topics for organizations. To this end, it seeks to identify in the literature how the application of the first (blockchain) improves the execution of the second (knowledge management) and how this impacts the third (sustainability).
Evaluation of the efficacy of topicalTerminalia chebulaRetz. with vinegar in the treatment of tinea corporis: a non-inferiority randomized controlled trial
Authors: Tasneem Parapur Sumayya , Husain Nazim , Khalid Mohd , Mamdapur Saba Abdul Razzaq , Kauser Khan Khan Ameer 
Published: April 2023

AbstractObjectivesUnani physicians have suggested a wide range of anti-dermatophytic remedies, although the scientific evidence is scarce. Thus, the efficacy and safety ofTerminalia chebulaRetz. fruit powder mixed with vinegar was compared with terbinafine hydrochloride 1% cream in the treatment of tinea corporis in order to establish the non-inferiority of test drugs.MethodsThe primary outcome measures were change in the presence or absence of hyphae on KOH mount test, change in pruritus severity assessed on 100 mm VAS and change in physician’s global assessment. Secondary outcome measure was change in the dermatology life quality index (DLQI). Hemograms, serum creatinine, serum bilirubin, and random blood sugar levels were measured at the baseline and after treatment to ensure the safety of the interventions.ResultsA per-protocol analysis was done on 40 participants (21 in the test group and 19 in the control group). The observed differences in the primary and secondary outcomes between the test and control groups were greater than the non-inferiority margin, signifying that the test drugs were not inferior.ConclusionsIt may be inferred that the trial drugTerminalia chebulaRetz. fruit powder mixed with vinegar is not inferior to terbinafine hydrochloride cream in the treatment of tinea corporis.
Investigation of dielectric, impedance, and magnetodielectric behavior in Bi5Ti3FeO15–Bi2Fe4O9 composites prepared by sol–gel modified method
Authors: Jena Rasmita , Chandrakanta Kouru , Singh Anil Kumar 
Published: April 2023

Abstract
We report detailed studies of the dielectric, impedance, and magnetodielectric properties of sol–gel synthesized (1−x)Bi5Ti3FeO15–(x)Bi2Fe4O9, x = 0.1 composites. The Rietveld refinement of X-ray diffraction data confirms the presence of mixed phases Bi5Ti3FeO15 (A21
am) and Bi2Fe4O9 (Pbam) with the orthorhombic crystal structure. The average grain size of the sample is calculated from scanning electron microscopy and found to be 0.74 µm and 0.80 µm for BTFO and BFO samples, respectively. The room temperature dielectric behavior of the prepared composite is demonstrated over a frequency range (102 Hz to 106 Hz) and at different fixed magnetic fields (0 T to 1.3 T). The decreasing trend of dielectric dispersion and loss signifies the presence of negative magnetodielectric and magneto-loss in the composite. Frequency-dependent magnetoresistance through impedance spectroscopy has been carried out to analyze the origin of the observed MD effect. The magnetic field-dependent MD and ML exhibit maximum coupling of about −0.19% and −0.36% at 50 kHz, respectively. The obtained MD response in this composite is due to the grain (capacitive) effect. These results establish a relation between the electric and magnetic order in the composites and extend their application in the field of magnetic memory and sensor devices.
Reduced graphene oxide synthesis by dry planetary ball milling followed by arc plasma treatment of high pure graphite
Authors: Sahoo Prakash Chandra , Dash Tapan , Mallick Subash Ch , Biswal Surendra Kumar 
Published: April 2023

Abstract
We have successfully prepared a challenging and wonderful material, reduced graphene oxide (RGO)/graphene with improved quality from high pure graphite (HPG) efficiently by planetary ball milling process followed by arc plasma treatment under hydrogen atmosphere. Graphene oxides (GO) have been synthesized with varying degrees of oxidation via the planetary ball milling route by milling HPG between 3 – 8 h. The lowest C/O ratio (0.965) was observed for the 8 h ball milled sample. The as-prepared GOs were taken for only five min of arc plasma treatment under a hydrogen atmosphere. As the typical GO (prepared by 8 h ball milling) underwent a reduction by plasma treatment for producing a typical RGO sample, it was found that the C/O ratio increased from 0.965 in GO to 14.86 in RGO. RGO shows a hexagonal structure with well-defined crystallinity. Bi-layered and transparent types of structures were found in the RGO sample. The typical plasma treated RGO sample (prepared from 8 h ball milled GO sample) exhibits extraordinary BET surface area and electrical conductivity values of 1230.0 m2 g−1 and 4.587 × 103 S cm−1, respectively, compared to those of HPG.