bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccine hesitancy among healthcare workers in low- and middle-income countries during the COVID-19 pandemic: Results from facility surveys across six countries
Authors: Baral Prativa , Ahmed Tashrik , Amor Fernandez Pablo , Peters Michael A. , Drouard Salome Henriette Paulette , Muhoza Pierre , Mwinnyaa George , Mwansambo Charles , Nzelu Charles , Tassembedo Mahamadi , Uddin Md. Helal , Wesseh Chea Sanford , Yansane Mohamed Lamine , Bergeron Julie Ruel , Karibwami Alain-Desire , Lopez Chicheri Tania Inmaculada Ortiz de Zuniga , Ogunlayi Munirat Iyabode Ayoka , Sieleunou Isidore , Hashemi Tawab , Hansen Peter M. , Shapira Gil 
Published: July 2023

Background
Vaccine hesitancy remains a critical barrier in mitigating the effects of the ongoing COVID-19 pandemic. The willingness of health care workers (HCWs) to be vaccinated, and, in turn, recommend the COVID-19 vaccine for their patient population is an important strategy. This study aims to understand the uptake of COVID-19 vaccines and the reasoning for vaccine hesitancy among facility-based health care workers (HCWs) in LMICs.

Methods
We conducted nationally representative phone-based rapid-cycle surveys across facilities in six LMICs to better understand COVID-19 vaccine hesitancy. We gathered data on vaccine uptake among facility managers, their perceptions of vaccine uptake and hesitancy among the HCWs operating in their facilities, and their perception of vaccine hesitancy among the patient population served by the facility.

Results
1,148 unique public health facilities participated in the study, with vaccines being almost universally offered to facility-based respondents across five out of six countries. Among facility respondents who have been offered the vaccine, more than 9 in 10 survey respondents had already been vaccinated at the time of data collection. Vaccine uptake among other HCWs at the facility was similarly high. Over 90% of facilities in Bangladesh, Liberia, Malawi, and Nigeria reported that all or most staff had already received the COVID-19 vaccine when the survey was conducted. Concerns about side effects predominantly drive vaccine hesitancy in both HCWs and the patient population.

Conclusion
Our findings indicate that the opportunity to get vaccinated in participating public facilities is almost universal. We find vaccine hesitancy among facility-based HCWs, as reported by respondents, to be very low. This suggests that a potentially effective effort to increase vaccine uptake equitably would be to channel promotional activities through health facilities and HCWs.However, reasons for hesitancy, even if limited, are far from uniform across countries, highlighting the need for audience-specific messaging.
Prevalence and factors associated with depression, anxiety, and stress among people with disabilities during COVID-19 pandemic in Bangladesh: A cross-sectional study
Authors: Roy Nitai , Amin Md. Bony , Mamun Mohammed A. , Sarker Bibhuti , Hossain Ekhtear , Aktarujjaman Md. 
Published: July 2023

Background
The COVID-19 pandemic has had a profound impact on the mental health of individuals across various populations. People with disabilities (PWDs) are particularly vulnerable to these effects, yet there is a lack of studies investigating the mental health of PWDs in Bangladesh. This study aims to investigate the prevalence of and factors associated with depression, anxiety, and stress among PWDs during the COVID-19 pandemic in Bangladesh.

Methods
Data was collected through interviews with 391 PWDs between December 2020 and February 2021. Demographic information, clinical characteristics, and scores from the Depression, Anxiety, and Stress Scale (DASS-21) were obtained. Chi-square tests and logistic regression analyses were conducted to examine the relationship between psychological measures and potential risk factors.

Results
The prevalence was found to be 65.7% for depression, 78.5% for anxiety, and 61.4% for stress, respectively. Several factors were identified as associated with these mental health issues, including gender (male), marital status (being married), low education levels, multiple impairments, comorbid medical illnesses, poor sleep quality, rural residency, hearing disability, disability onset later in life, and testing positive for COVID-19.

Conclusions
The prevalence was found to be 65.7% for depression, 78.5% for anxiety, and 61.4% for stress, respectively. Several factors were identified as associated with these mental health issues, including gender (male), marital status (being married), low education levels, multiple impairments, comorbid medical illnesses, poor sleep quality, rural residency, hearing disability, disability onset later in life, and testing positive for COVID-19.
Persistent Gastrointestinal Symptoms in Human Mpox
Authors: MacDonald Maria , Barker Kim , Umar Imran , Carpentier Stephanie 
Published: July 2023

ABSTRACT
Mpox is a zoonotic disease caused by the double-stranded DNA Mpox virus (MPXV). Little information has been published regarding the gastrointestinal system and MPXV. This case presents a patient with active ileitis and 60 days of functionally limiting diarrhea after confirmation of MPXV. A diagnosis of postinfectious irritable bowel syndrome was made; however, despite a lack of apparent viral shedding on stool polymerase chain reaction, it remains possible that prolonged diarrhea represented direct sequelae from the MPXV disease. This is important from a public health perspective, suggesting that our ability to recommend removal from isolation may need to be reconsidered.
Análise da eficiência de um instituto federal
Authors: Silveira Nauana Gaivota , Maciel Sula Patricia , Giracca Cesar Nunes , Fries Carlos Ernani 
Published: July 2023

A eficiência é um princípio da Constituição Brasileira. Entretanto, mensurá-lo na área da educação superior revela-se um desafio, tendo em vista a subjetividade e complexidade envolvidas. O objetivo desta pesquisa é analisar a eficiência do Instituto Federal de Santa Catarina (IFSC), buscando identificar campus de referência e os principais pontos de ineficiência, proporcionando um processo de melhoria por meio de benchmarking interno. Para tanto, realizou-se pesquisa predominantemente quantitativa, descritiva, com análise documental de dados secundários da instituição do ano de 2021. Uma vez que há diversos inputs e outputs envolvidos, optou-se pela Análise de Envoltória de Dados (DEA), que tem como base problemas de programação linear (PPL) para determinar a eficiência de unidades produtivas (DMUs) - neste caso, os campi, por meio do Software EMS, associado ao Statistics. Análises de correlação e de componentes principais foram aplicadas aos inputs e outputs disponíveis para identificação das variáveis mais adequadas ao modelo, sendo inputs: Área, Docentes e Matrículas Equivalentes; já os outputs: Concluintes, Projetos de Pesquisa e Projetos de Extensão. Foram identificados como campus de referência os campi Canoinhas, Caçador, São Lourenço do Oeste, Urupema e Xanxerê. Os principais pontos de ineficiência foram Jaraguá do Sul e Itajaí. Identificou também a maior parte dos campi fora da escala ótima. Como medidas gerenciais para elevação do desempenho, sugeriu-se predominantemente a elevação dos outputs projetos de pesquisa e extensão - medida de implementação com maior caráter discricionária da instituição. Destacou-se que não é interesse da instituição e da sociedade reduzir o porte dos campi, sendo importante optar pela elevação dos outputs com a manutenção dos quantitativos de inputs. Esta pesquisa contribui com o conhecimento sobre eficiência nas Instituições de Ensino Superior, mais especificamente nos Institutos Federais, trazendo um estudo de caso que permite análises comparativas em busca da otimização dos recursos e redução das ineficiências.
PERANCANGAN STRATEGI PENGELOLAAN RISIKO PEMANGKU KEPENTINGAN BERBASIS PROSES BISNIS PADA PT X
Authors: Prihartono Budhi , Annasthacia Gracella Audrey Phlycia , Fahlevi Fidruzal 
Published: July 2023

PT X merupakan perusahaan tambang pasir di daerah Cimangkok, Sukabumi yang sedang mengalami kesulitan dalam mencapai target produksi. PT X memiliki target produksi pasir sebesar 600-700 m3 per bulan namun rata-rata hasil produksi hanya mencapai 400-500 m3per bulan. Penelitian ini bertujuan untuk mengelola risiko pemangku kepentingan yang menghambat perusahaan dalam mencapai target produksinya. Untuk memperoleh hasil analisis risiko yang lebih holistik, penelitian akan meninjau analisis interaksi risiko dengan integrasi metode Interpretive structure modelling dan matriks MICMAC. Hasil analisis risiko pemangku kepentingan menunjukkan bahwa terdapat empat risiko utama yang masuk ke dalam kategori risiko influent dan perlu dikelola oleh perusahaan, yaitu komunikasi yang kurang efektif antar pekerja, hambatan operasional akibat human error, pekerja tidak melakukan operasi sesuai dengan prosedur, dan kurangnya pekerja dengan kapabilitas dan pengetahuan yang memadai. Risiko-risiko ini berasal dari proses bisnis inti yang berkaitan dengan proses bisnis penambangan pasir. Untuk mengelola risiko pemangku kepentingan PT X, hasil studi mengusulkan 4 strategi, yaitu perbaikan struktur organisasi perusahaan, penyusunan job description, penyusunan standard operating procedure, dan pelatihan serta sertifikasi keterampilan teknis pekerja. Abstract[Title: Strategy Design for Pemangku kepentingan-Risk Management Based on Business Process at PT X] PT X is a sand mining company located in Cimangkok area, Sukabumi, which is experiencing difficulties in achieving production targets. With a target of 600-700 m3, PT X can only manage to reach an average of 400-500 m3 sand production. This study aims to manage pemangku kepentingan risk at PT X. To obtain a more holistic risk analysis result, this study involves risk interaction analysis with the integration of the ISM and MICMAC methods. The result shows that there are four main risks from the influential category that need to be managed by the company: ineffective communication among workers, operational problems caused by human error, workers not performing their works according to procedures, and lack of workers with adequate capabilities and knowledge. This risk comes from core business processes that are related to sand mining. To manage the risk of PT X's stakeholders, the results of the study propose 4 strategies: improvement of the company's organizational structure, development of job description, development of standard operating procedures, and training as well as technical certification for workers.Keywords: core business process; stakeholder risk; risk interaction; risk mitigation; ISM-MICMAC
PENGARUH KUALITAS WEBSITE TERHADAP TINGKAT KEPUASAN PELANGGAN MENGGUNAKAN METODE LINIER REGRESI BERGANDA
Authors: Purwaningsih Ratna , Shobrina Salsa Fadlila , Rumita Rani , Nurlaila Diah , Winata Pidi 
Published: July 2023

Penelitian ini bertujuan untuk menguji hubungan antara dimensi-dimensi kualitas website terhadap tingkat kepuasan pelanggan terhadap website Tiket.com. Data diperoleh dengan kuesioner terhadap 141 responden pengguna situs Tiket.com. Uji validitas dan reliabilitas dilakukan untuk menguji konstruk penelitian, uji asumsi klasik dilakukan untuk memastikan persamaan regresi yang didapatkan konsisten dan tidak bias. Pengujian model dilakukan dengan metode analisis regresi linier berganda. Hasil analisis menunjukkan bahwa: desain website, keamanan dan privasi, serta empati memiliki pengaruh yang positif dan signifikan terhadap kepuasan pelanggan, sedangkan, interaktivitas, konten dan informasi, reliabilitas, serta daya tanggap tidak secara signifikan mempengaruhi kepuasan pelanggan. Rekomendasi untuk situs Tiket.com adalah pengembangan website untuk meningkatkan kepuasan pelanggan. Abstract[Analysis the Impact of Websitesite Quality on Customer Satisfaction Level using Multiple Linear Regression Method (Case Study: Tiket.com)] This study examines the relationship between the dimensions of website site quality to customer satisfaction level on the Tiket.com website. Data was collected from 141 respondents who were users of the Tiket.com website. A validity and reliability test was conducted to test the research constructs, and a classic assumption test was also undertaken to ensure that the regression equation obtained was correct, unbiased, and consistent. Multiple linear regression analysis was then carried out to test the model. The analysis of this study indicated that website site design, security, privacy, and empathy have a positive and significant influence on customer satisfaction. While interactivity, content and information, reliability, and responsiveness do not significantly affect customer satisfaction. The recommendation for the website site is website site development to increase customer satisfaction.Keywords: website quality; customer satisfaction; multiple linear regression
Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2
Authors: Ruan Zijing , Tang Jiaxi , Zeng Mingtang , Fan Ping 
Published: July 2023

Abstract
Since the outbreak of the novel coronavirus nearly 3 years ago, the world’s public health has been under constant threat. At the same time, people’s travel and social interaction have also been greatly affected. The study focused on the potential host targets of SARS-CoV-2, CD13, and PIKfyve, which may be involved in viral infection and the viral/cell membrane fusion stage of SARS-CoV-2 in humans. In this study, electronic virtual high-throughput screening for CD13 and PIKfyve was conducted using Food and Drug Administration-approved compounds in ZINC database. The results showed that dihydroergotamine, Saquinavir, Olysio, Raltegravir, and Ecteinascidin had inhibitory effects on CD13. Dihydroergotamine, Sitagliptin, Olysio, Grazoprevir, and Saquinavir could inhibit PIKfyve. After 50 ns of molecular dynamics simulation, seven compounds showed stability at the active site of the target protein. Hydrogen bonds and van der Waals forces were formed with target proteins. At the same time, the seven compounds showed good binding free energy after binding to the target proteins, providing potential drug candidates for the treatment and prevention of SARS-CoV-2 and SARS-CoV-2 variants.
Clown doctors virtualized: hospital professionals’ perception regarding online visits during confinement in Portuguese public hospitals
Authors: Peceguina Inês , Alcântara Iêda , Santos Anabela C. , Diab Flávia , Carvalho Sílvia 
Published: July 2023

Abstract
Clown doctors’ artistic interventions directed to hospitalized children in the Portuguese public hospitals have been performed over the last 20 years, uninterruptedly. During the Covid-19 pandemic, the doctor clowns’ visits were interrupted, but soon after resumed in some hospitals, by means of visits online. The present study evaluates hospital professionals’ perception (n = 152) regarding clowns’ online visits. Participants were mostly nurses (n = 76), and child educators/teachers (n = 39) working in pediatrics (n = 139). Six months after the beginning of the visits, an online questionnaire was used to collect the data. A mixed-methods approach was used to analyse the data. Results indicate that most hospital professionals have a positive perception of online visits, considering that the quality of performance was preserved, and that children were engaged and benefited from the interactions. Moreover, participants acknowledge the organizations’ ability and promptness in developing an alternative way of visiting the children, even though some stressed that in-person visits are the most desirable format.
Using social robots for language learning: are we there yet?
Authors: Huang Guanyu , Moore Roger K. 
Published: July 2023

AbstractAlong with the development of speech and language technologies and growing market interest, social robots have attracted more academic and commercial attention in recent decades. Their multimodal embodiment offers a broad range of possibilities, which have gained importance in the education sector. It has also led to a new technology-based field of language education: robot-assisted language learning (RALL). RALL has developed rapidly in second language learning, especially driven by the need to compensate for the shortage of first-language tutors. There are many implementation cases and studies of social robots, from early government-led attempts in Japan and South Korea to increasing research interests in Europe and worldwide. Compared with RALL used for English as a foreign language (EFL), however, there are fewer studies on applying RALL for teaching Chinese as a foreign language (CFL). One potential reason is that RALL is not well-known in the CFL field. This scope review paper attempts to fill this gap by addressing the balance between classroom implementation and research frontiers of social robots. The review first introduces the technical tool used in RALL, namely the social robot, at a high level. It then presents a historical overview of the real-life implementation of social robots in language classrooms in East Asia and Europe. It then provides a summary of the evaluation of RALL from the perspectives of L2 learners, teachers and technology developers. The overall goal of this paper is to gain insights into RALL’s potential and challenges and identify a rich set of open research questions for applying RALL to CFL. It is hoped that the review may inform interdisciplinary analysis and practice for scientific research and front-line teaching in future.
Uncovering enzymatic structural adaptations from energy dissipation
Authors: Arango-Restrepo Andrés , Barragán Daniel , Rubi J. Miguel 
Published: July 2023

Abstract
While genetic mutations, natural selection and environmental pressures are well-known drivers of enzyme evolution, we show that their structural adaptations are significantly influenced by energy dissipation. Enzymes use chemical energy to do work, which results in a loss of free energy due to the irreversible nature of the process. By assuming that the catalytic process occurs along a potential barrier, we describe the kinetics of the conversion of enzyme-substrate complexes to enzyme-product complexes and calculate the energy dissipation. We show that the behaviour of the dissipated energy is a non-monotonic function of the energy of the intermediate state. This finding supports our main result that enzyme configurations evolve to minimise energy dissipation and simultaneously improve kinetic and thermodynamic efficiencies. Our study provides a novel insight into the complex process of enzyme evolution and highlights the crucial role of energy dissipation in shaping structural adaptations.
Regulation of the Ca2+Channel CaV1.2 Supports Spatial Memory and Its Flexibility and LTD
Authors: Ireton Kyle E. , Xing Xiaoming , Kim Karam , Weiner Justin C. , Jacobi Ariel A. , Grover Aarushi , Foote Molly , Ota Yusuke , Berman Robert , Hanks Timothy , Hell Johannes W. 
Published: July 2023

Widespread release of norepinephrine (NE) throughout the forebrain fosters learning and memory via adrenergic receptor (AR) signaling, but the molecular mechanisms are largely unknown. The β2AR and its downstream effectors, the trimeric stimulatory Gs-protein, adenylyl cyclase (AC), and the cAMP-dependent protein kinase A (PKA), form a unique signaling complex with the L-type Ca2+channel (LTCC) CaV1.2. Phosphorylation of CaV1.2 by PKA on Ser1928is required for the upregulation of Ca2+influx on β2AR stimulation and long-term potentiation induced by prolonged theta-tetanus (PTT-LTP) but not LTP induced by two 1-s-long 100-Hz tetani. However, the function of Ser1928phosphorylationin vivois unknown. Here, we show that S1928A knock-in (KI) mice of both sexes, which lack PTT-LTP, express deficiencies during initial consolidation of spatial memory. Especially striking is the effect of this mutation on cognitive flexibility as tested by reversal learning. Mechanistically, long-term depression (LTD) has been implicated in reversal learning. It is abrogated in male and female S1928A knock-in mice and by β2AR antagonists and peptides that displace β2AR from CaV1.2. This work identifies CaV1.2 as a critical molecular locus that regulates synaptic plasticity, spatial memory and its reversal, and LTD.SIGNIFICANCE STATEMENTWe show that phosphorylation of the Ca2+channel CaV1.2 on Ser1928is important for consolidation of spatial memory and especially its reversal, and long-term depression (LTD). Identification of Ser1928as critical for LTD and reversal learning supports the model that LTD underlies flexibility of reference memory.
CONTRIBUTION TO KNOWLEDGE ON THE TAXONOMIC COMPOSITION AND DISTRIBUTION OF NOCTUOID MOTHS (LEPIDOPTERA: NOCTUOIDEA) OF UKRAINE
Authors: Geryak Yu. M. , Khalaim Ye. V. , Suchkov S. I. , Zhakov O. V. , Bachynskyi A. I. , Bezuglyi S. K. , Bidychak R. M. , Galkin O. O. , Gera A. A. , Kavurka V. V. , Kovalchuk D. O. , Kozlov S. M. , Leshchenko M. V. , Novytskyi S. M. , Parkhomenko V. V. , Prostebi V. L. , Sergienko V. M. , Trotsenko S. M. , Tsykal S. V. , Voitko P. L. , Voronov V. K. , Yepishin V. V. , Zaika M. I. 
Published: July 2023

The paper contains data on the distribution of 265 species of Noctuoid moths (Lepidoptera: Noctuoidea), that are little-known, new for different regions or local and rare in Ukraine. One species, Episema amasina, is reliably registered for the first time in Ukraine and Europe as a whole; four species, Eublemma porphyrina, Grammodes bifasciata, Oncocnemis nigricula and Conistra ragusae, are recorded for the first time in Ukraine; three species: Dysauxes famula, Aporophyla nigra and Divaena haywardi are first revealed on the mainland of Ukraine; and one species, Mythimna congrua is found for the first time in the Ukrainian Carpathians and western part of Ukraine as a whole. A number of species appeared to be recorded for the first time in certain regions of Ukraine: 27 species — in Poltava Region, 25 — in Odesa Region, 19 — in Kirovohrad Region, 17 — in Kherson Region, 12 — in Ivano-Frankivsk Region, 9 — in Vinnytsia Region, 8 — in Zaporizhzhia Region, 7 — in Kyiv Region, 6 each — in Donetsk and Khmelnytskyi Regions, 5 each — in Chernihiv, Luhansk and Mykolaiv Regions, 4 each — in Volyn and Zhytomyr Regions, 3 — in Rivne Region, 2 each — in Chernivtsi, Sumy and Ternopil Regions, and one each — in Cherkasy, Kharkiv and Zakarpattia Regions. Moreover, new records for a number of local, rare and little-known (yet insufficiently studied in Ukraine) species, are also given.
Crowdsourcing Felt Reports Using the MyShake Smartphone App
Authors: Kong Qingkai , Allen Richard M. , Allen Steve , Bair Theron , Meja Akie , Patel Sarina , Strauss Jennifer , Thompson Stephen 
Published: July 2023

Abstract
MyShake is a free citizen science smartphone app that provides a range of features related to earthquakes. Features available globally include rapid postearthquake notifications, live maps of earthquake damage as reported by MyShake users, safety tips, and various educational features. The app also uses the accelerometer in the mobile device to detect earthquake shaking, and to record and submit waveforms to a central archive. In addition, MyShake delivers earthquake early warning alerts in California, Oregon, and Washington. In this study, we compare the felt shaking reports provided by MyShake users in California with the U.S. Geological Survey’s (USGSs) “Did You Feel It?” intensity reports. The MyShake app simply asks, “What strength of shaking did you feel?” and users report on a five-level scale. When the MyShake reports are averaged in spatial or time bins, we find strong correlation with the Modified Mercalli Intensity scale values reported by the USGS based on the DYFI surveys. The MyShake felt reports can therefore contribute to the creation of shaking intensity maps.