bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of M-DEPTH Model of Depression Care on Maternal HIV Viral Suppression and Adherence to the PMTCT Care Continuum Among HIV-Infected Pregnant Women in Uganda: Results from a Cluster Randomized Controlled Trial at Pregnancy Completion
Authors: Wagner Glenn J. , Gwokyalya Violet , Faherty Laura , Akena Dickens , Nakigudde Janet , Ngo Victoria , McBain Ryan , Ghosh-Dastidar Bonnie , Beyeza-Kashesya Jolly , Nakku Juliet , Kyohangirwe Leticia , Nabitaka Linda Kisaakye , Lukwata Hafsa , Mukasa Barbara , Wanyenze Rhoda K. 
Published: March 2023

AbstractPerinatal depression has been shown to impede adherence to antiretroviral therapy (ART) and the prevention of mother-to-child transmission (PMTCT) care continuum; therefore, treating perinatal depression may result in increased viral suppression and PMTCT adherence. We examined the effects of the M-DEPTH (Maternal Depression Treatment in HIV) depression care model (including antidepressants and individual Problem Solving Therapy) on depression, maternal viral suppression and adherence to PMTCT care processes in an ongoing cluster-randomized controlled trial of 391 HIV-infected pregnant women (200 usual care; 191 intervention) with at least mild depressive symptoms enrolled across 8 antenatal care clinics in Uganda. At baseline, 68.3% had clinical depression and 41.7% had detectable HIV viral load. Adjusted repeated-measures multivariable regression models found that the intervention group was nearly 80% less likely to be clinically depressed [Adjusted OR (95% CI) 0.22 (0.05, 0.89)] at the 2-month post-pregnancy assessment, compared to the control group. However, the intervention and control groups did not differ meaningfully on maternal viral suppression, ART adherence, and other PMTCT care processes and outcomes. In this sample of women who were mostly virally suppressed and ART adherent at baseline, the depression care model had a strong effect on depression alleviation, but no downstream effects on viral suppression or other PMTCT care processes.Trial Registration NIH Clinical Trial Registry NCT03892915 (clinicaltrials.gov).
Reconceiving Argument Schemes as Descriptive and Practically Normative
Authors: Larson Brian N. , Morrison David Seth 
Published: March 2023

AbstractWe propose a revised definition of “argument scheme” that focuses on describing argumentative performances and normative assessments that occur within an argumentative context, the social context in which the scheme arises. Our premise-and-conclusion structure identifies the typical instantiation of an argument in the argumentative context, and our critical framework describes a set of normative assessments available to participants in the context, what we call practically normative assessments. We distinguish this practical normativity from the rationally or universally normative assessment that might be imposed from outside the argumentative context. Thus, the practical norms represented in an argument scheme may still be subject to rational critique, and the scheme avoids the is/ought fallacy. We ground our theoretical discussion and observations in an empirical study of US district court opinions resolving legal questions about copyright fair use and the lawyers’ briefs that led to them, instantiating our definition of argument scheme in the “argument for classification by precedent.” Our definition addresses some criticisms the argument-scheme construct has received. For example, using our data, we show that a minimally well formed instance of this type of argument does not shift any conventional burden from the proponent of the argument to its skeptics. We also argue that these argument schemes need not be seen as dialogical.
Negative frequency dependent prey selection by two canid predators and its implications for the conservation of a threatened rodent in arid Australia
Authors: Sheldon Elizabeth L. , Feit Benjamin , Feit Anna , Letnic Mike 
Published: March 2023

AbstractUnprecedented anthropogenic changes to biodiversity and biogeography demand a greater understanding of the consequences of altered faunal composition for ecosystem functioning. Selective predation has important, yet poorly understood effects on ecosystem stability, and can be strongly influenced by the relative frequencies of different prey types in the environment. Yet, how predators adjust their selection for prey according to their environmental frequency is often overlooked. Here, we assessed frequency dependent selection of prey by dingoes and foxes in the Australian desert, biannually, across a nine-year period (2007–2016). Both predators exhibited potentially destabilizing, negative frequency dependent selection for prey. Foxes persisted to preferentially consume a threatened, native rodent (Notomys fuscus) when it was environmentally scarce. Bolstered by the observation that N.fuscus occurs at low densities in areas where foxes are common, our results suggest that N.fuscus is particularly vulnerable to predation by this predator; possibly because it is naïve and/or lacks adaptations to avoid or escape predation by the relatively recently introduced fox. Dingoes tended to consume reptiles when they were scarce; potentially constituting a conservation concern if selected reptilian taxa are threatened. Foxes avoided, thus were unlikely to control populations of overabundant kangaroos, while both foxes and dingoes showed a preference for, and may therefore control populations of invasive rabbits. The integration of our results into the relative suites of (de)stabilizing influences exerted by dingoes and foxes is important to provide a more dynamic insight into how each predator impacts their naturally fluctuating ecosystems.
Remnant habitat patches provide high value for a wide range of insect species in a timber plantation mosaic
Authors: van der Mescht Aileen C , Pryke James S , Gaigher René , Samways Michael J 
Published: March 2023

AbstractSpecies present in transformed landscapes utilise resources from either the transformed patches, natural patches, or both. Depending on the degree to which species are specialised, species-specific responses to landscape transformation is both varied and dynamic. Understanding species-specific responses across a landscape is therefore essential to make informed conservation decisions. We investigate how spillover of stenotopic, cultural, and ubiquitous insect species respond to the different edge combinations present in a timber plantation mosaic. We use a multi-taxon approach, sampling two distinct insect assemblages (ground and foliage) across four different biotopes in a grassland-forest-plantation landscape in the Midlands of KwaZulu-Natal, South Africa, which forms part of the Maputaland-Pondoland-Albany biodiversity hotspot. We show that in this landscape, ecological networks consisting of natural grassland and forest supported high insect diversity in both ground and foliage assemblages. The foliage assemblage displayed stronger responses to the different biotope combinations than the ground assemblage. There was remarkably little spillover of habitat specialist species of either the ground or foliage assemblages from grassland or forest into the plantation stands. The few species associated with plantation stands (cultural species) had consistent levels of spillover across different types of plantation blocks, but not into the natural areas. Natural biotopes in this landscape conserved many habitat specialists, whereas plantations maintained low levels of diversity. Thus, we recommend that conservation practitioners consider the fidelity and spillover of the species present in the local landscape before designing conservation plans in these dynamic production landscapes.
Using Oncotype DX breast recurrence score® assay to define the role of neoadjuvant endocrine therapy in early-stage hormone receptor-positive breast cancer
Authors: Taylor Caitlin , Meisel Jane , Foreman Aimee J. , Russell Christy , Bandyopadhyay Dipankar , Deng Xiaoyan , Floyd Lisa , Zelnak Amelia , Bear Harry , O’Regan Ruth 
Published: March 2023

Abstract
Purpose
The role of neoadjuvant endocrine therapy in the treatment of patients with early-stage, hormone receptor-positive (HR +) breast cancer is not well defined. Tools to better determine which patients may benefit from neoadjuvant endocrine therapy versus chemotherapy or upfront surgery remain an unmet need.

Methods
We assessed the rate of clinical and pathologic complete response (cCR, pCR) among a pooled cohort of patients with early-stage HR + breast cancer who had been randomized to neoadjuvant endocrine therapy or neoadjuvant chemotherapy in two earlier studies to understand better how outcomes varied by Oncotype DX Breast Recurrence Score® assay.

Results
We observed that patients with intermediate RS results had no statistically significant differences in pathologic outcomes at the time of surgery based on whether they received neoadjuvant endocrine therapy or neoadjuvant chemotherapy, suggesting that a subgroup of women with a RS 0–25 may omit chemotherapy without compromising outcomes.

Conclusion
These data suggest that Recurrence Score® (RS) results may serve as a useful tool in treatment decision-making in the neoadjuvant setting.
Antitumor activity of the PI3K δ-sparing inhibitor MEN1611 in PIK3CA mutated, trastuzumab-resistant HER2 + breast cancer
Authors: Fiascarelli Alessio , Merlino Giuseppe , Capano Stefania , Talucci Simone , Bisignano Diego , Bressan Alessandro , Bellarosa Daniela , Carrisi Corrado , Paoli Alessandro , Bigioni Mario , Tunici Patrizia , Irrissuto Clelia , Salerno Massimiliano , Arribas Joaquin , de Stanchina Elisa , Scaltriti Maurizio , Binaschi Monica 
Published: March 2023

Abstract
Purpose
Dysregulation of the PI3K pathway is one of the most common events in breast cancer. Here we investigate the activity of the PI3K inhibitor MEN1611 at both molecular and phenotypic levels by dissecting and comparing its profile and efficacy in HER2 + breast cancer models with other PI3K inhibitors.

Methods
Models with different genetic backgrounds were used to investigate the pharmacological profile of MEN1611 against other PI3K inhibitors. In vitro studies evaluated cell viability, PI3K signaling, and cell death upon treatment with MEN1611. In vivo efficacy of the compound was investigated in cell line- and patient-derived xenografts models.

Results
Consistent with its biochemical selectivity, MEN1611 demonstrated lower cytotoxic activity in a p110δ-driven cellular model when compared to taselisib, and higher cytotoxic activity in the p110β-driven cellular model when compared to alpelisib. Moreover, MEN1611 selectively decreased the p110α protein levels in PIK3CA mutated breast cancer cells in a concentration- and proteasome-dependent manner. In vivo, MEN1611 monotherapy showed significant and durable antitumor activity in several trastuzumab-resistant PIK3CA-mutant HER2 + PDX models. The combination of trastuzumab and MEN1611 significantly improved the efficacy compared to single agent treatment.

Conclusions
The profile of MEN1611 and its antitumoral activity suggest an improved profile as compared to pan-inhibitors, which are limited by a less than ideal safety profile, and isoform selective molecules, which may potentially promote development of resistance mechanisms. The compelling antitumor activity in combination with trastuzumab in HER2 + trastuzumab-resistant, PIK3CA mutated breast cancer models is at the basis of the ongoing B-Precise clinical trial (NCT03767335).
Implications for surveillance for breast cancer patients based on the internally and externally validated BRENDA-metastatic recurrence score
Authors: Ebner Florian , Salmen Jessica , Dayan Davut , Kiesel Matthias , Wolters Regine , Janni Wolfgang , Wöckel Achim , Wischnewsky Manfred 
Published: March 2023

Abstract
Purpose
Although the incidence of distant relapse is decreasing, 20–30% of patients with early breast cancer die of metastasis. The aim of this study is to characterize patients with metastasis-free survival(MFS) less than 5 years, to analyze the most probable site of metastases according to the internally and externally validated BRENDA-score. The BRENDA-score is a combination of the biological subtype and clinical staging.

Method
3832 patients with primary diagnosis of breast cancer and either distant metastatic recurrence within 5 years or MFS ≥ 5 years were assigned to this study. Patients were classified for metastatic recurrence according to the BRENDA-score. 1765 patients were in a validation set. Statistical methods were Kaplan–Meier curves, Cox regression analysis, Exhausted CHAID, likelihood-ratio tests and the Nearest Neighbor Estimation method.

Results
There was a significant(p < 0.001) difference between the Kaplan–Meier MFS-functions of M0-patients stratified by BRENDA-score. The BRENDA score outperforms intrinsic subtypes and the Nottingham prognostic score. It fits the original data and the validation set equally well (p = 0.179).There was a significant(p < 0.001) difference between mean BRENDA-Index for patients with MFS < 5y(21.0 ± 9.0) and patients with MFS ≥ 5y(mean BRENDA-Index 11.7 ± 8.2). 55.6% of the very high risk patients(BRENDA-Index ≥ 27) had metastases within 5 years. The most likely primary metastatic site was bone(30%) followed by liver(19%) and lung(18%). The discriminatory ability(areas under the time dependent ROC curve) of the BRENDA score is good to acceptable for the first 5 years. In the very low/low risk (intermediate, high/very high) risk group 50% of all metastases were diagnosed within 26 months. Guideline adherence had a highly significant influence on outcome independent of the risk group.

Conclusion
The evaluation showed that the BRENDA-Score is a robust predictive tool for breast cancer recurrence and site of metastases in the first five years after diagnosis. It outperforms intrinsic subtypes and the Nottingham prognostic score. The BRENDA-score could be a tool for a risk orientated and targeted follow up.
Goal-Based Private Sustainability Governance and Its Paradoxes in the Indonesian Palm Oil Sector
Authors: Grabs Janina , Garrett Rachael D. 
Published: March 2023

AbstractIn response to stakeholder pressure, companies increasingly make ambitious forward-looking sustainability commitments. They then draw on corporate policies with varying degrees of alignment to disseminate and enforce corresponding behavioral rules among their suppliers and business partners. This goal-based turn in private sustainability governance has important implications for its likely environmental and social outcomes. Drawing on paradox theory, this article uses a case study of zero-deforestation commitments in the Indonesian palm oil sector to argue that goal-based private sustainability governance’s characteristics set the stage for two types of paradoxes to emerge: performing paradoxes between environmental, social, and economic sustainability goals, and organizing paradoxes between cooperation and competition approaches. Companies’ responses to these paradoxes, in turn, can explain the lack of full goal attainment and differential rates of progress between actors. These results draw our attention to the complexities hidden behind governance through goal setting in the corporate space, and raise important questions about the viability of similar strategies such as science-based targets and net-zero goals.
Pharmacological Inhibition of P-Rex1/Rac1 Axis Blocked Angiotensin II-Induced Cardiac Fibrosis
Authors: Pan Jianyuan , Liu Ming , Su Huimin , Hu Hao , Chen Hongwu , Ma Likun 
Published: March 2023

Abstract
Purpose
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor-1 (P-Rex1), as one of the members of Rac-GEFs, has been proven to play a critical role in cancer progression and metastasis. Nonetheless, its role in cardiac fibrosis remains elusive. In the present study, we aimed to investigate whether and how the P-Rex1 mediates AngII-induced cardiac fibrosis.

Method
A cardiac fibrosis mouse model was established by chronic AngII perfusion. The heart structure, function, pathological changes of myocardial tissues, oxidative stress, and cardiac fibrotic protein expression were determined in an AngII induced mouse model. To provide a molecular mechanism for P-Rex1 involvement in cardiac fibrosis, a specific inhibitor or siRNA was used to block P-Rex1, and target the relationship between Rac1-GTPase and its downstream effector.

Results
Blocking P-Rex1 showed down-regulation of its downstream effectors such as the profibrotic transcriptional regulator Paks, ERK1/2, and ROS generation. Intervention treatment with P-Rex1 inhibitor 1A-116 ameliorated AngII-induced abnormalities in heart structure and function. Moreover, pharmacological inhibition of the P-Rex1/Rac1 axis showed a protective effect in AngII-induced cardiac fibrosis through the down-regulation of collagen1, CTGF, and α-SMA expression.

Conclusion
Our findings demonstrated for the first time that P-Rex1 was an essential signaling mediator in CFs activation and subsequent cardiac fibrosis, and 1A-116 could be a potential pharmacological development drug.
Effect of pretreated cow dung fiber on rheological and fatigue properties of asphalt binder
Authors: Niu Dongyu , Zhang Zhao , Gao Yangming , Li Yuanxiao , Yang Zhengxian , Niu Yanhui 
Published: March 2023

AbstractCow dung waste has caused severe environmental pollution and public health issues in China. In this study, the cow dung residues were used as a cheap renewable fiber to modify asphalt binder, providing a new solution for the proper disposal of cow dung waste. Three cow dung fibers with two lengths were prepared using different treatments, including original cow dung fiber (CDF), surface treatments of cow dung fiber (STCDF) and alkali treatments of cow dung fiber (ATCDF). The physicochemical properties of CDF, STCDF and ATCDF were analyzed by scanning electron microscope (SEM) and thermogravimetry (TG). The viscidity, rheological properties and fatigue characteristics of CDF modified asphalt binders (CDFMA) were evaluated using Brookfield viscometer and dynamic shear rheometer. The results showed that the rough surfaces of STCDF and ATCDF improved their thermal stability. STCDF and ATCDF enhanced the resistance to permanent deformation under high temperature conditions of modified asphalt binder. STCDF modified asphalt binders exhibited the best viscosity and rheological performance. The increase of fiber length was positively correlated with the high temperature deformation resistance of CDFMA. CDF, STCDF and ATCDF inhibited fatigue cracking of modified asphalt binders compared to base asphalt binders. ATCDF modified asphalt binders exhibited higher fatigue life and smaller crack under the same cyclic loading. The increase in fiber length had a slight improvement on the fatigue resistance of modified asphalt binders.
Sense of Belonging at School and on Social Media in Adolescence: Associations with Educational Achievement and Psychosocial Maladjustment
Authors: Fabris Matteo Angelo , Settanni Michele , Longobardi Claudio , Marengo Davide 
Published: March 2023

AbstractBelongingness is a key factor in the psychological development and school adjustment of children and adolescents. Going beyond the existing literature, the present study evaluated the association between two sources of belongingness, namely sense of belonging at school (SOBAS) and on social media (SOBOSM), and both psychological maladjustment and educational achievement. Sample consisted of 698 early-to-late adolescents (52.3% female, mean age = 13.79 ± 2.09). Both SOBAS and SOBOSM showed negative direct associations with psychological maladjustment. SOBOSM showed a negative direct association with educational achievement. Social media addiction mediated the links between both SOBAS and SOBOSM and psychological maladjustment and education achievement. Overall, findings suggest that adolescents reporting high sense of belonging both at school and on social media may at lower risk for psychological maladjustment. However, adolescents reporting low SOBAS and high SOBOSM may also be a greater risk of SMA, possibly impacting their psychological health and school adjustement.
Incorporating Indigenous voices in regional climate change adaptation: opportunities and challenges in the U.S. Pacific Northwest
Authors: Dent Lauren A. , Donatuto Jamie , Campbell Larry , Boardman Marnie , Hess Jeremy J. , Errett Nicole A. 
Published: March 2023

AbstractAs the impacts of climate change increasingly and disproportionately affect indigenous peoples, equitable approaches to regional climate change adaptation must center the voices, needs, and priorities of Indigenous communities. Although the tribal climate change principles identify actionable recommendations to address the unique needs of Indigenous peoples in the contexts of climate change adaptation efforts undertaken at the Federal level in the United States (U.S.), there has yet to be exploration of how such principles might be applied at the regional level. Through semi-structured qualitative interviews with 18 representatives from inter-Tribal organizations and non-Tribal organizations engaged in regional climate adaptation in the U.S. Pacific Northwest, this research sought to describe challenges faced by, and opportunities available to, non-Tribal entities when engaging with Tribes on regional climate adaptation initiatives. All respondents reported high levels of motivation to work with Tribes on climate adaptation and identified several perceived benefits of integrating Tribal partnerships and indigenous ways of knowing into regional climate adaptation initiatives. Respondents underscored the need for strong, trusted relationships that respect the sovereignty and priorities of Tribal nations to guide engagement. However, non-Tribal organizations’ own capacity constraints, perceived Tribal capacity constraints, and institutional cultures rooted in colonialism and structural racism were discussed as obstacles to meaningful engagement. As such, we identify an urgent need to prioritize sustained investments in both Tribal and non-Tribal actors’ partnership capacities and climate change adaptation capabilities to place Indigenous voices and needs at the forefront of regional climate change adaptation planning and implementation.
Optimal control of the stationary Kirchhoff equation
Authors: Hashemi Masoumeh , Herzog Roland , Surowiec Thomas M. 
Published: March 2023

AbstractWe consider an optimal control problem for the steady-state Kirchhoff equation, a prototype for nonlocal partial differential equations, different from fractional powers of closed operators. Existence and uniqueness of solutions of the state equation, existence of global optimal solutions, differentiability of the control-to-state map and first-order necessary optimality conditions are established. The aforementioned results require the controls to be functions in$$H^1$$H1and subject to pointwise lower and upper bounds. In order to obtain the Newton differentiability of the optimality conditions, we employ a Moreau–Yosida-type penalty approach to treat the control constraint and study its convergence. The first-order optimality conditions of the regularized problems are shown to be Newton differentiable, and a generalized Newton method is detailed. A discretization of the optimal control problem by piecewise linear finite elements is proposed and numerical results are presented.