bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthcare resource use and costs reduction with aripiprazole once-monthly in schizophrenia: AMBITION, a real-world study
Authors: Sanchez-Gistau Vanessa , Moreno María José , Gómez-Lus Susana , Sicras-Mainar Antoni , Crespo-Facorro Benedicto 
Published: August 2023

ObjectiveThis study aims to compare the hospitalization rate in individuals with schizophrenia who started their treatment with aripiprazole once monthly (AOM400) or atypical oral antipsychotics (OA) in Spain.MethodsThis is an observational and retrospective study based on the electronic medical records from the BIG-PAC database. The study population consisted of individuals diagnosed with schizophrenia who initiated their treatment with AOM400 (AOM cohort) or atypical OA (OA cohort) from 01/01/2017 to 31/12/2019. A 1:1 propensity score matching (PSM) procedure was conducted to match individuals of both cohorts. The number and duration of hospitalizations, persistence to treatment, healthcare resources use, and costs were analyzed after 12 months.ResultsAfter the PSM, 1,017 individuals were included in each cohort [age: 41.4 years (SD: 10.6); males: 54.6%]. During the follow-up period, the AOM cohort had a 40% lower risk of hospitalization than the OA group [HR: 0.60 (95% confidence interval, CI: 0.49–0.74)]. The median time to the first hospitalization was longer in individuals with AOM400 compared to those with OA (197 days compared to 174 days; p &lt; 0.004), whereas hospital admissions were shorter (AOM400: 6 compared to OA: 11 days; p &lt; 0.001). After 12 months, individuals receiving AOM400 were more persistent than those with OA (64.9% compared to 53.7%; p &lt; 0.001). The OA cohort required more healthcare resources, mainly visits to primary care physicians, specialists, and emergency rooms than those receiving AOM400 (p ≤ 0.005 in all comparisons). AOM400 reduced the costs of hospitalizations, and emergency room, specialist and primary care visits by 50.4, 36.7, 16.1, and 10.9%, respectively, in comparison to the treatment with atypical OA. AOM400 led to annual cost savings of €1,717.9 per individual, from the societal perspective.ConclusionAripiprazole once monthly reduces the number and duration of hospitalizations, together with the treatment costs of schizophrenia, as it reduces the use of healthcare resources and productivity losses in these individuals.
Slouching towards engagement: interactions between people using psychedelics naturalistically and their healthcare providers
Authors: Boehnke Kevin F. , Cox Kasey , Weston Cody , Herberholz Moss , Glynos Nicolas , Kolbman Nicholas , Fields Christopher W. , Barron Julie , Kruger Daniel J. 
Published: August 2023

IntroductionThere is substantial public interest in psychedelics as potential treatments for psychiatric conditions. However, most psychedelics are criminalized under federal law in the USA, so it is unclear whether use occurs with clinical support. Our objective was to assess whether naturalistic psychedelic use occurs with clinical support, interactions between those using psychedelics and healthcare providers (psychiatrist, therapist, or primary physicians), and use characteristics.MethodsWe conducted an online, anonymous, confidential, cross-sectional survey of adults reporting psychedelic use (N = 1221) through a psychedelics advocacy event and social media between 9/18/2022 and 11/5/2022. We assessed participant disclosure of psychedelic use with their psychiatric care provider (PsyCP) and/or primary care provider (PCP), desire for provider support, access to support, and rate of taking prescribed psychoactive medications alongside psychedelics.ResultsAmong participants with such care providers, 22% disclosed psychedelic use to their PCP vs. 58% to their PsyCP. Participants were less confident in PCP vs. PsyCP ability to integrate psychedelics into treatment. Common reasons for nondisclosure included stigma, inadequate provider knowledge, and legal concerns. 23% reported taking psychedelics on the same day as potentially interacting psychiatric medications (e.g., anxiolytics, antidepressants). Despite 81% of participants desiring therapist support during psychedelic experiences, only 15% had received such support.DiscussionOur results show that psychedelic use is generally disconnected from primary and psychiatric clinical care. This disconnection may result in safety issues, including inadequate screening for contraindicated conditions, lack of support during emergent adverse events, and drug interactions. Enhanced clinical education and orienting drug policy towards known harms and benefits of psychedelics is needed.
Reframing human trafficking awareness campaigns in the United States: goals, audience, and content
Authors: Savoia Elena , Piltch-Loeb Rachael , Muibu Daisy , Leffler Amy , Hughes Diana , Montrond Alberto 
Published: August 2023

IntroductionHuman trafficking (HT) awareness campaigns can educate the public and specific professional figures about this crime and ways to prevent it. However, there currently remains a gap in terms of how to best frame such campaigns without stigmatizing groups of individuals or portraying victims in unrealistic ways.MethodsWe conducted four focus groups with 22 experts in HT to explore their perspectives and opinions on current challenges in the framing of HT awareness campaigns in the United States. Focus groups were conducted via Zoom and transcribed verbatim. Two independent reviewers analyzed the transcripts to identify themes using an inductive approach. The results of the focus groups analysis were used to structure the guiding questions of a brainstorming technique named Nominal Group Technique (NGT). Fifteen of 22 experts that participated in the focus groups joined the in-person NGT with the intent of generating ideas and achieving consensus on target audiences, goals, and content of human trafficking awareness campaigns. At the end of the NGT participants ranked priority for actions in the development of HT awareness efforts in the United States.ResultsDuring the NGT the experts provided a number of recommendations to improve HT awareness and to empower victims to reach for help. They pointed to the need for: awareness efforts that describe HT on a spectrum of human abuse and exploitation; training for professional figures about trauma-informed care and communication; and efforts that empower trafficked victims to seek support. They also pointed to the need to develop awareness efforts tailored to local needs in close collaborations with the community-based organizations that can champion their dissemination and be the primary point of access for victims seeking help.
Tres indigenismos a través de periódicos y revistas literarias y culturales (1930-1950)
Authors: Rocha Velasco Pedro Omar 
Published: August 2023

Éste es un fragmento del texto leído en el evento “Artistas en diálogo, Juan Rimsa y su tiempo”, realizado entre el 25 y 26 de marzo de 2019; no se publica, por falta de espacio, la tercera parte llamada “Reververaciones del Titikaka”.
En este texto recupero la resemantización propuesta por Rosario Rodríguez en su tesis doctoral sobre el indigenismo literario boliviano y latinoamericano: “un espacio de articulación que, atravesando demarcaciones rigurosas, permita seguir el hilo a esas manifestaciones discursivas donde se confrontan, encuentran, interpelan, rechazan, comprometen diversidades heterogéneas, a partir de esa oposición radical primera entre mundo indio/mundo occidental del indigenismo clásico. Pretendo respetar la multiplicidad y divergencia de una secuencia artística no uniforme y no caer en la visión única de un proceso lineal” (2008, pp. 8-9).
Pengaruh Kegiatan Membatik dengan Media Tisu Terhadap Kemampuan Motorik Halus Anak Kelompok A di RA Muslimat NU 151 Manarotul Ulum
Authors: Wulandari Lisfi , Simatupang Nurhenti Dorlina 
Published: August 2023

The main focus in this reseacrh is fine motor skills. Conditions in the scope show that in the folding activity it is still not symmetrical, when stamped batik is still not flexible in moving its hand movements. One of the fine motor skill stimulation that can be given to children is batik activities using tissue media. This reseacrh was used to measure the effect of batik activities using tissue media on the fine motor skills of group A children at RA Muslimat NU 151 Manarotul Ulum. This type of research is quantitative Quasi Experimental with a Nonequivalent Control Group Design. The samples in this study were group A children at RA Muslimat NU 151 Manarotul Ulum (experimental group) and group A1 children at RA YKUI Sambogunung (kontrol group). The data collection techniques are observation and documentation. The data analysis technique uses an independent sample T test with IBM SPSS Statistics 25. The test results show that the significance value of (2-tailed) is 0.023 <0.05, so Ha is accepted and H0 is rejected. This activities treatment (batik using tissue media) has an effect on the fine motor skills of group A children at RA Muslimat NU 151 Manarotul Ulum.
ABSTRAK
Fokus utama pada penelitian ini yaitu motorik halus. Kondisi di lapangan menunjukkan bahwa dalam kegiatan melipat masih kurang simetris, saat kegiatan membatik cap masih kurang luwes dalam menggerakkan gerakan tangannya. Salah satu stimulasi motorik halus yang dapat diberikan kepada anak adalah kegiatan membatik dengan media tisu. Penelitian ini bertujuan untuk mengukur pengaruh kegiatan membatik dengan media tisu terhadap kemampuan motorik halus anak kelompok A di RA Muslimat NU 151 Manarotul Ulum. Jenis penelitian ini adalah kuantitatif Quasi Eksperimental dengan rancangan Nonequivalent Kontrol Group Design. Sampel pada penelitian ini adalah anak kelompok A di RA Muslimat NU 151 Manarotul Ulum (kelompok eksperimen) dan anak kelompok A1 di RA YKUI Sambogunung (kelompok kontrol). Teknik pengumpulan datanya yaitu observasi dan dokumentasi. Teknik analisis datanya menggunakan uji independent sample T test dengan IBM SPSS Statistics 25. Hasil uji tersebut diperoleh bahwa nilai signifikansi (2-tailed) yaitu 0.023 < 0.05 maka Ha diterima dan H0 ditolak. Jadi, terdapat pengaruh treatment kegiatan membatik dengan media tisu terhadap kemampuan motorik halus anak kelompok A di RA Muslimat NU 151 Manarotul Ulum.
Pengembangan Buku Ajar Berbantuan Kartu Kwartet Pada Materi Biologi Semester Genap Kelas XI SMA/MA
Authors: Salmawati Salmawati , B Nurhayati , Adnan Adnan 
Published: August 2023

Penelitian ini merupakan penelitian pengembangan dengan model ADDIE yang terdiri dari tahapan analyze, design, development, implementation dan evaluation. Sampel penelitian ini adalah peserta didik SMAN 1 Wonomulyo kelas XI MIPA 5. Penelitian ini dilakukan pada bulan Januari - Juni 2021. Buku ajar berbantuan kartu kwartet yang dikembangkan berdasarkan komponen pembelajaran kontekstual yaitu constructivism, questioning, inquiry, learning community, modeling, reflection dan authentic assessment. Buku ajar berbantuan kartu kwartet yang dikembangkan kemudian diuji validitas hingga dinyatakan valid oleh validator lalu diimplementasikan untuk mengetahui observasi keterlaksanaan, respon guru dan respon peserta didik. Hasil penelitian menunjukkan bahwa buku ajar berbantuan kartu kwartet yang dikembangkan memenuhi kriteria kevalidan (4,7), kepraktisan dari hasil lembar observasi keterlaksanaan berada pada kategori terlaksana dengan baik (4.5), respon guru berada pada kategori sangat positif (90%), respon peserta didik berada pada kategori sangat positif (86%). Dengan demikian dapat disimpulkan bahwa buku ajar berbantuan kartu kwartet yang dikembangkan telah memenuhi kriteria valid dan praktis.
Pengembangan E-Learning Berbasis LMS Computational Thinking Platform Flipped Classroom di SMA Negeri 18 Luwu Utara
Authors: Haryanti Haryanti , Daud Firdaus , Danial Muhammad 
Published: August 2023

This research aims to produce LMS-based Biology e-learning media at SMA Negeri 18 Luwu Utara that is valid, practical and effective, as well as analyze the practicality and effectiveness of the developed e-learning media . The research method used is Research & Development (R&D mode used is the Development Model of Robert Maribe Branch (2009) with 5 stages in a cycle, namely ADDIE (Analysis, Design, Development, Evaluation). Sampling uses a simple random sampling technique. The sample of this study is class XII MIPA1 which amounts to 34 students. Kevalidan, Practicality is collected with questionnaire and validation sheets, for effectiveness data is collected with test sheets. Data collection is carried out by testing the validity of products, providing learning outcome tests, collecting student and teacher response data. The data collected was analyzed using quantitative descriptive analysis with the results: 1) The validity of media experts and materials received valid categories from 2 validators; 2) Classical completion of learning outcomes of 88.23%; 3) Teachers and students respond positively to the product, 4) there is a significant link between practicality and effectiveness of the media. Based on the results of the study, the e-learning media developed is declared valid, practical and effective.
RGB monolithic GaInN-based μLED arrays connected via tunnel junctions
Authors: Saito Tatsunari , Hasegawa Naoki , Imura Keigo , Suehiro Yoshinobu , Takeuchi Tetsuya , Kamiyama Satoshi , Iida Daisuke , Ohkawa Kazuhiro , Iwaya Motoaki 
Published: August 2023

Abstract
We report a 330 ppi monolithic RGB micro light-emitting diodes (μLED) array of blue, green and red GaInN-based LEDs stacked on the same wafer. Considering it is challenging to form ohmic electrodes on the plasma-etched p-type GaN surface, GaInN-based tunnel junctions were used to connect each LED, and anode electrodes for the blue and green LEDs were formed on n-type AlGaN. The fabricated stacked monolithic μLED arrays were tested at room temperature (approximately 26 °C) and DC. Each μLED emitted blue, green and red with peak wavelengths of 486, 514 and 604 nm at a current density of 50 A cm−2.
O POVO KARAJÁ DE ARUANÃ-GO/BRASIL: TURISMO, TERRITÓRIO E VIDA INDÍGENA
Authors: DA SILVA Lorranne Gomes , DE LIMA Sélvia Carneiro , NAZARENO Elias 
Published: August 2023

O presente artigo analisa questões referentes ao turismo, o território e a vida indígena do povo Karajá que se localiza no município de Aruanã, no Estado de Goiás - Brasil. Aruanã está inserida na Região Turística Vale do Araguaia, conjunto complexo de dinâmica do capital e diferentes interesses econômicos. Desse modo, ao considerar as apropriações dos territórios, especialmente, no que se refere as atividades turísticas, é preciso repensar sobre os distintos usos e consequências de como essas práticas são instituídas, sobretudo, quando se trata de territórios indígenas. As pesquisas apontaram que o contato interétnico e a inserção dos Karajá nas demandas mercadológicas do turismo sem planejamento adequado, culminou em ressignificações socioculturais. Esta pesquisa é qualitativa e etnográfica e foi desenvolvida a partir de levantamento bibliográfico, trabalho e caderneta de campo, observação participante, roda de conversas, registros de narrativas e imagens.
Colorectal Cancer in a 17-Year-Old Boy: A Case Report
Authors: Iswandi Febi , Asri Rizky E. , Lihawa Nur Fitriany , A.B Dewandaru Istighfaris 
Published: August 2023

Introduction: Colorectal cancer is the fifth most common malignant neoplasm worldwide. Commonly found in adults, the adolescent population is scarce. Colorectal cancer diagnosed and treated late is potentially associated with the worst prognosis.Case: A 17-year-old boy was admitted to the hospital due to a distended abdomen and abdominal pain, nausea, and vomiting that he had been experiencing seven days prior. The patient neither had a bowel movement nor flatus for the day. Abdominal ultrasound showed a regional intraluminal mass on the right upper quadrant with a suspicion of an appendical mass with a differential diagnosis of intussusception, colon tumor, and obstructive ileus. Acute abdominal series showed small bowel obstruction. When the surgery was performed, there was a tumor in the hepatic flexure of the colon. Histopathological examination revealed colon adenocarcinoma.Conclusion: The incidence of colorectal cancer in adolescents has increased. Right extended hemicolectomy was performed in this case, but the patient refused the chemotherapy. The patient was readmitted to the hospital five months later, was only given palliative therapy in the Intensive Care Unit, and died two weeks later. We believe that had the chemotherapy been performed, the patient might have had a better prognosis. This case report will help increase awareness among doctors and surgeons in including colorectal carcinoma as a differential diagnosis in adolescents so that it can shorten the delay in diagnosis, which in turn will endanger the patient's prognosis.Keywords: Colorectal cancer; Adenocarcinoma; Adolescents
Medicial Education Strategy In The Era of Digitalization and Disruption
Authors: Ihsan Maimun , Masaong Abdul Kadim 
Published: August 2023

Background: This article aims to (1) examine the current condition of education in the digitalization and disruption era and (2) examine medical education strategies in the digitalization and disruption era. Writing scientific papers is based on library research, whose object of study uses library data in the form of books as a data source.Content: Based on the literature review, it was found that: (1) global medical education currently uses the SPICES strategy (student-centered learning, problem-based, integrated, community-based, elective, and systematic), accompanied by nine educational trends; (2) SPICES is a medical education strategy that will produce graduate profiles that refer to World Health Organization (WHO) and World Organization of Family Doctor (WONCA) conference agreements. A doctor must have six-star doctor characteristics, namely: care provider, decision makers, communicators, community leaders, managers as well as creators and innovators; (2) the minimum standard of competence for doctors in Indonesia, constitute of seven areas of graduate competency namely; has noble professionalism, is always aware and develops himself, can communicate effectively, is reliable in managing information, always has a scientific basis in medical science, has clinical skills and can manage health problems well.Conclusion: A special strategy for medical education is required in the era of digitalization and disruption by applying a lifelong education approach. Indonesian medical education uses the SPICES strategy to create six-star doctors and master the seven defined competency areas.
Borderline ovarian tumors: twenty years of experience at a tertiary center
Authors: SAHİN Fatih , AKTÜRK Erhan , GÜNKAYA Osman Samet , ÖZDEMİR Savaş , KONAL Merve , GENÇ Simten , YURCİ Arzu , AKBAYİR Ozgur 
Published: August 2023

Aims: To investigate whether there is a difference between serum tumor markers panel (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) and tumor size and histopathology in well-staged patients with borderline ovarian tumors (BOTs).
Methods: Over the past 20 years (January 2001 to January 2021), the results of four tumor markers (CA 125, CA 19-9, CA 15-3, and carcinoembryonic antigen (CEA)) have been clinically analyzed for for this retrospective cohort study of 156 patients who underwent surgery and were diagnosed with histopathology consistent with a borderline ovarian tumor.
Results: The average age of patients with borderline ovarian tumors was determined to be 51.67 (4.726) years. Before the first surgery, high CA 125 levels (>35 U/l) were found in 53 patients (34%), high CEA levels (>4 ng/ml) were found in 24 patients (15.4%), high CA 19-9 levels (>37 U/ml) were found in 29 patients (18.6%), and high CA 15-3 (>30 ng/ml) levels were found in 12 patients (7.7%). The average CA 125 levels in tumors with serous histopathology [372.8 (1805.2)] were higher than those in tumors with mucinous histopathology (p=0.006). There was no statistically significant difference in tumor markers between tumors smaller than 8 cm and larger than 8 cm [(CA 125 p=0,257), (CEA p=0.9), (CA 19-9 p=0.295), (CA 15-3 p=0.404)].
Conclusion: Our primary outcome of the study is an increase in CA 125 levels, which indicates serous histopathology. Our secondary outcome is the higher levels of tumor markers, but it does not suggest larger tumors.
Lung immune prognostic index as a prognostic predictor in patients with advanced small cell lung cancer
Authors: SÖYLER Yasemin , AKIN KABALAK Pınar , KAVURGACI Suna , AYYÜREK Merve , ÖZTÜRK Ayperi , YILMAZ Ülkü 
Published: August 2023

Aims: Identifying prognostic markers in advanced small-cell lung cancer (A-SCLC) patients is important. Therefore, our study aimed to evaluate the prognostic value of pretreatment lung immune prognostic index (LIPI) in A-SCLC.
Methods: This was a retrospective and observational study of A-SCLC patients treated with platinum plus etoposide chemotherapy as first-line treatment. The association of LIPI with progression-free survival (PFS) and overall survival (OS) was analysed.
Results: One hundred eighteen patients were included in this study and divided into three groups LIPI 0 (n=27, 22.9%), LIPI 1 (n=57, 48.3%) and LIPI 2 (n=34, 28.8%). The median PFS of LIPI groups (0/1/2) was 8.9 (95% CI 3.83-13.96), 8 (95% CI 6.41-9.58), and 5.6 (95% CI 4.60-6.60) months, respectively (p=0.1) The median OS of LIPI groups (0/1/2) was 12 (95% CI 9.11-14.88), 10.1 (95% CI 9.16-11.03), and 7.7 (95% CI 6.55-8.84) months, respectively (p=0.02). Cox regression analysis revealed that LIPI 2 score was an independent risk factor for both PFS (HR 1.839, 95% CI: 1.075-3.144, p=0.02) and OS (HR 1.757, 95% CI: 1.006-3.071, p=0.04).
Conclusion: LIPI score can be used as a simple and easily accessible marker to predict prognosis for A-SCLC patients.
The role of saline infusion sonohysterography in the evaluation of infertility
Authors: ÖZOKÇU Ekin , ŞAHİN AKER Seda , AĞAR Eser , BERKER Bülent 
Published: August 2023

Aims: The study aimed to evaluate possible intrauterine pathologies that may not be visible in basal transvaginal ultrasonography in infertile patients using saline infusion sonohysterography.
Methods: Between January 2019 and January 2020, 110 patients who presented to the Ankara University Faculty of Medicine, Obstetrics and Gynecology Infertility Polyclinic were enrolled in the study. Saline infusion sonohysterography was performed on primary and secondary infertile patients who were not diagnosed with endometrial pathology via ultrasonography.
Results: Pathological findings were detected in 11 out of 110 patients (10.6%) during saline infusion sonohysterography, including polyps, myomas, and adhesions. These patients were referred to hysteroscopy by their practitioner. After the procedure, pathological findings were detected in 54.5% of cases by hysteroscopy. According to these data, the sensitivity of saline infusion sonohysterography in detecting intracavitary pathologies was 60%, specificity was 80.7%, positive predictive value was 54.5%, negative predictive value was 84%, and reliability was 75%.
Conclusion: Saline infusion sonohysterography can detect endometrial pathologies not identified by TV USG, suggesting its cost-effective addition to routine evaluations for infertile patients and potential endometrial pathologies.