bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress, Challenges, and the Nexus of Research and Impact - the importance of technology in biodiversity conservation in Indonesia
Authors: Priatna Dolly , Monk Katryn A. 
Published: August 2023

The Global Assessment Report on Biodiversity and Ecosystem Services 2019, published by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), shed light on the increasingly alarming state of global biodiversity. Biodiversity is essential to human survival through its contribution to ecosystem stability, resilience, and the provision of critical ecosystem services that sustain essential ecological processes and human well-being. Amongst other services, as demonstrated across Indonesia, biodiversity supports livelihoods by providing building and clothing materials, maintaining water quality, and providing medicines and food. As the global human population reached 8 billion in 2022, the interconnections between our unsustainable production and consumption, the climate crisis, and biodiversity decline have been increasingly recognized by the global community through IPBES and IPCC (Intergovernmental Panel on Climate Change). Escalating human numbers, coupled with burgeoning economic and industrial demands, must necessitate substantial forest land use—repositories of biodiversity. Conservation practitioners have therefore been continually driven to innovate in their pursuit of effective strategies for sustainably managing the world's precious biodiversity. Researchers and academics have the pivotal responsibility to produce research that brings about real-world impactful outcomes. The academic community is expected to address the needs of those working to conserve nature through the development of research and technology with immediate practical applicability. We look forward to publishing more of these research impact papers in the future.
Immunocytometric analysis of patients with thymic epithelial tumors revealed that COVID-19 vaccine booster strongly enhanced the immune response
Authors: Cernera Gustavo , Gelzo Monica , De Placido Pietro , Ottaviano Margaret , Pietroluongo Erica , Raia Maddalena , Scalia Giulia , Tortora Marianna , Castaldo Giuseppe , Formisano Pietro , Palmieri Giovannella , Giuliano Mario 
Published: August 2023

BackgroundThymic epithelial tumors (TETs) are rare malignancies with heterogeneous clinical manifestations. The high frequency of autoimmune paraneoplastic disorders observed in such patients requires caution when using COVID-19 vaccines. Furthermore, TETs are often associated with severe immunodeficiency, making it difficult to predict vaccine immunization. Therefore, we aimed to evaluate immune response to COVID-19 vaccine in patients with TETs.MethodsWe conducted a prospective study enrolling patients who underwent the SARS-Cov-2 mRNA full vaccine cycle (two doses plus a booster after 6 months of BNT162b2). All patients were enrolled before receiving 1st vaccine dose and were followed over the vaccination cycle for up to 6 months after the booster dose to i) assess humoral and cellular responses, ii) define biomarkers predictive of effective immunization, and iii) evaluate the safety of the vaccine.ResultsAt the end of the full vaccine cycle, 27 (61.4%) patients developed humoral and 38 (86.4%) cellular responses (IFN γ release by stimulated cells) and showed an increase in activated TH1 and TH17 cells, particularly significant after the booster dose. The number of B and T lymphocytes at baseline was predictive of humoral and cellular responses, respectively. Patients with no evidence of tumor lesions had a higher probability of achieving a humoral response than those with evidence of the disease. Furthermore, the percentage of patients with immune-related disorders (75%), particularly Good’s syndrome (47.7%) and myasthenia gravis (29.5%), did not change over the entire vaccine cycle. Overall, 19 of the 44 enrolled patients (43.2%) had COVID-19 during the observation period; none required hospitalization or oxygen support, and no fatalities were observed.ConclusionSARS-Cov-2 mRNA vaccine determines the immune responses in patients with TET, particularly after the booster dose, and in patients with no evidence of tumor lesions. Preliminary analysis of B and T lymphocytes may help identify patients who have a lower probability of achieving effective humoral and cellular responses and thus may need passive immunization. The vaccine prevented severe COVID-19 infection and is safe.
Phenotypes in children with GNAO1 encephalopathy in China
Authors: Li Yanmei , Chen Hong , Li Lin , Cao Xueyan , Ding Xin , Chen Li , Cao Dezhi 
Published: August 2023

BackgroundThe GNAO1 gene encodes the α-subunit (Gαo) of the heterotrimeric guanine nucleotide-binding protein (G protein). The aim of this study was to explore the clinical characteristics of patients with GNAO1 pathogenic variations.MethodsTen patients with pathogenic variations in GNAO1 were enrolled from the Shenzhen Children's Hospital. Clinical data from several cases previously reported from China were also included and analyzed.ResultsTwenty-seven patients with variations in GNAO1 were analyzed (10 patients from Shenzhen Children's Hospital, 17 patients from previously published studies) including 12 boys and 15 girls. The median age of onset was 3 months with moderate to severe global developmental delay. Nineteen different GNAO1 heterozygous variants were identified. Epilepsy was observed in 18 patients (67%, 18/27), movement disorder (MD) was observed in 22 patients (81%, 22/27), and both were seen in 13 patients (48%, 13/27). Seizures typically presented as focal seizures in all patients with epilepsy. MD typically presented as dystonia and chorea. Loss-of-function (LOF) or partial loss-of-function (PLOF) mutations were more frequent in patients with developmental and epileptic encephalopathy (p = 0.029). Interictal electroencephalograms showed multifocal or diffuse epileptiform discharges. The most common magnetic resonance imaging finding was widened extracerebral space. In contrast to MD, in which improvements were not common, seizures were easily controlled by anti-seizure medications. Severe dystonia in three patients was effectively treated by deep brain stimulation. Seven (26%, 7/27) patients died of respiratory complications, status dystonicus, choreoathetosis, or sudden unexpected death in epilepsy.ConclusionWe analyzed clinical data of 27 cases of GNAO1-related encephalopathy in China. MD seemed to be the central feature and was most difficult to control. LOF or PLOF variants were significantly associated with developmental and epileptic encephalopathy. The active intervention of severe dystonia may prevent death due to status dystonicus. However, future studies with larger samples are needed to confirm these results.
A social network analysis: mental health scales used during the COVID-19 pandemic
Authors: Chen Shuang , Lan Xue , Yu Han 
Published: August 2023

IntroductionThe focus on psychological issues during COVID-19 has led to the development of large surveys that involve the use of mental health scales. Numerous mental health measurements are available; choosing the appropriate measurement is crucial.MethodsA rule-based named entity recognition was used to recognize entities of mental health scales that occur in the articles from PubMed. The co-occurrence networks of mental health scales and Medical Subject Headings (MeSH) terms were constructed by Gephi.ResultsFive types of MeSH terms were filtered, including research objects, research topics, research methods, countries/regions, and factors. Seventy-eight mental health scales were discovered.DiscussionThe findings provide insights on the scales used most often during the pandemic, the key instruments used to measure healthcare workers’ physical and mental health, the scales most often utilized for assessing maternal mental health, the tools used most commonly for assessing older adults’ psychological resilience and loneliness, and new COVID-19 mental health scales. Future studies may use these findings as a guiding reference and compass.
Prevalence of insulin resistance in Chinese solar greenhouse and field workers: evidence from a solar greenhouse and field workers study
Authors: Yan Tenglong , Wang Minghui , Yang Siwen , Wang Yuqian , Zhou Xingfan , Zhu Xiaojun , Ma Wenjun , Tang Shichuan , Li Jue 
Published: August 2023

Evidence suggests that agricultural workers are at higher risk of insulin resistance (IR), but few studies have investigated IR in solar greenhouse workers, who are exposed to higher concentrations of agricultural risk factors than traditional agricultural workers. A prevalence study was conducted in a greenhouse vegetable farm in China. In total, 948 participants were enrolled in this study. Among them, 721 participants were allocated to the greenhouse worker group (G group), and 227 participants were assigned to the field worker group (F group). The TyG index, which is an indicator to evaluate prediabetes (IR), was calculated by the formula: TyG index = ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. To evaluate the associations of TyG index alternation with solar greenhouse and field work, multiple linear regression (MLR) and logistic regression models were performed. The TyG index in the G group (8.53 ± 0.56) was higher than that in the F group (8.44 ± 0.59) (p &lt; 0.05). Solar greenhouse work was positively associated with an increased TyG index in both the multiple linear regression model [β = 0.207, (0.006, 0.408)] and the logistic regression model [OR = 1.469, (1.070, 2.016)]. IR was associated with the solar greenhouse work. However, the determination of agricultural hazard factors needs to be further strengthened to improve exposure assessment.Graphical Abstract
Core decompression vs. allogenic non-vascularized bone grafting in patients with osteonecrosis of the femoral head
Authors: Mei Jin , Jiang Zai-ping , Pang Li-li , Huang Yingtao , Gong Yu , Zhu Jun , Zhang Ling-wei 
Published: August 2023

BackgroundCore decompression and allogenic non-vascularized bone grafting are used in the early stage of osteonecrosis of the femoral head for a period. Since the comparison of the core decompression and allogenic non-vascularized bone grafting are less reported, the purpose of our study was to investigate the difference of two procedures in patients with the osteonecrosis of the femoral head.MethodsBetween January 2018 and January 2019, 59 patients (64 hips) were divided into core decompression group and non-vascularized bone grafting group according to their procedures. The primary outcomes are visual analog score (VAS) and Harris hip score. Survivorship was analyzed with the collapse of the femoral head or conversion to total hip arthroplasty (THA) as the endpoint.ResultsAt the final follow-up, two hips underwent THA in the core decompression group and three hips in the allogenic non-vascularized bone grafting group. The radiographic survival rates were 76.9% and 77.3%, respectively, in both groups. The VAS of the core decompression group was 6.08 ± 1.164 and 3.30 ± 1.431 before and 2 years after operation (P &lt; 0.05), respectively. The VAS of the allogenic non-vascularized bone grafting group was 6.00 ± 1.209 and 3.15 ± 1.537 before and 2 years after operation (P &lt; 0.05), respectively. The Harris hip score of the core decompression group was 52.49 ± 6.496 before operation, and 2 years after operation, it increased by 81.14 ± 8.548 (P &lt; 0.05); The Harris hip score of allogenic the non-vascularized bone grafting group was 53.56 ± 5.925 and 81.33 ± 7.243 before and 2 years after operation (P &lt; 0.05), respectively. In the core decompression group, body mass index (BMI) &gt;25 kg/m2 was correlated with the collapse of femoral head or conversion to THA [P &lt; 0.05; 95% confidence interval (CI), 0.006–1.334], and Association Research Circulation Osseous (ARCO) III was correlated with the collapse of femoral head or conversion to THA (P &lt; 0.05; 95% CI, 2.514–809.650). In the allogenic non-vascularized bone grafting group, age, BMI, and ARCO stage were significantly associated with the collapse of femoral head or conversion to THA (P &gt; 0.05).ConclusionThe clinical survival rate of the femoral head in the core decompression group was slightly better than that in the allogenic non-vascularized bone grafting group. There was no significant difference in the radiographic survival rate of the femoral head between the two groups. Both groups can alleviate pain and improve functional of patients, but there was no significant difference in the degree of improvement. In the core decompression group, BMI &gt;25 kg/m2 and ARCO III correlated with the collapse of femoral head or conversion to THA. In the allogenic non-vascularized bone grafting group, no association was found between age, BMI, and ARCO stage and the collapse of femoral head or conversion to THA.Level of evidenceIII.
Vitamin D Receptor Gene Polymorphism Predicts the Outcome of Multidisciplinary Rehabilitation in Multiple Sclerosis Patients
Authors: Guerini Franca Rosa , Agliardi Cristina , Oreni Letizia , Groppo Elisabetta , Bolognesi Elisabetta , Zanzottera Milena , Caputo Domenico , Rovaris Marco , Clerici Mario 
Published: August 2023

Better knowledge about the possible role of genetic factors in modulating the response to multiple sclerosis (MS) treatment, including rehabilitation, known to promote neural plasticity, could improve the standard of care for this disease. Vitamin D receptor (VDR) gene polymorphisms are associated with MS risk, probably because of the role played by vitamin D in regulating inflammatory and reparative processes. The aim of this study was to evaluate the association of the most important functional VDR SNPs (TaqI (T/C), ApaI (A/C), and FokI (C/T)) with functional outcome in MS patients undergoing multidisciplinary inpatient rehabilitation (MDR) treatment, in order to determine whether genetic profiling might be useful to identify subjects with a higher chance of recovery. To this end, 249 MS inpatients with a diagnosis of either progressive (pMS; n = 155) or relapsing remitting (RRMS; n = 94) disease who underwent MDR treatment (average duration = 5.1 weeks) were genotyped for VDR SNPs by real-time allelic discrimination. The rehabilitation outcome was assessed using the modified Barthel Index (mBI), Expanded Disability Status Scale (EDSS), and pain numerical rating scores (NRS) at the beginning and the end of MDR treatment. A positive correlation was observed in RRMS patients between the VDR TaqI major allele (TT) and mBI increase (i.e., better functional recovery), as assessed by the linear and logistic regression analysis adjusted for gender, age, disease duration, time of hospitalization, HLA-DRB1*15.01 positivity, and number of rehabilitative interventions (Beta = 6.35; p = 0.0002). The VDR-1 TaqI, ApaI, FokI: TCC haplotype was also associated with mBI increase in RRMS patients (Beta = 3.24; p = 0.007), whereas the VDR-2: CAC haplotype was correlated with a lower mBI increase (Beta = −2.18 p = 0.04) compared with the other haplotypes. VDR TaqI major allele (TT), as well as the VDR-1 TaqI, ApaI, FokI: TCC haplotype could be associated with a better rehabilitation outcome in RRMS patients.
Hambatan belajar peserta didik pada konsep faktor persekutuan terbesar
Authors: Sumarni Cici , Ramadianti Winda , Syofiana Mardiah , Jumri Rahmat 
Published: August 2023

Learning can be achieved optimally if students have no learning obstacle, so that the learning process can be carried out smoothly. If a concept is fully mastered, there will be no learning obstacle. This study aims to determine the learning obstacle that occur in the material of the greatest common factor and one way to overcome these learning obstacles is to make a didactic design. The approach used in this research is qualitative method (Didactical Design Research). Data collection techniques were carried out by giving respondent ability tests (TKR), interviews, and documentation for class VII students of a SMPN in Bengkulu City. From this study, it was found that ontogeny learning barriers, namely students experiencing obstacles regarding the prerequisite material of FPB, namely division and epistemological barriers, namely the definition of factors, common factors, and the greatest common factor.
Analisis kesulitan siswa dalam pembelajaran matematika menggunakan model pembelajaran inkuiri
Authors: Simatupang Intan Khadijah , Narpila Suci Dahlya 
Published: August 2023

One of the learning models that can be applied in the 2013 curriculum is the inquiry learning model. By using the inquiry learning model which can build student activity in participating in mathematics learning, it is very necessary in inquiry learning so that mathematics can become a fun lesson. The same thing is also based on observations at the Mawaridussalam Islamic boarding school Batang Kuis showing that educators have carried out for one semester using the Inquiry Based Learning model. However, students experience difficulties in learning Mathematics. This is caused by differences in student learning outcomes with students' understanding abilities. The method used in this research is qualitative method. In this study, the subjects were all VII-C class students at the Mawaridussalam Islamic Boarding School for the 2022/2023 academic year with a total of 25 students. This research uses a descriptive method by describing students' difficulties in learning mathematics using the Inquiry Based Learning model in class VII-C of the Mawaridussalam Islamic Boarding School in the 2022/2023 academic year. The results of the study indicate that there are several difficulties faced by students in learning mathematics in using the inquiry learning model at the Mawaridussalam Islamic boarding school, namely: (1) technical difficulties, including the learning process which is carried out in a long way (2) students' adaptation difficulties, including feeling bored, embarrassed to ask friends, and difficult to understand learning (3) difficulties in the condition of the teacher, including the lack of preparation in lesson planning.
Complications of uneventful phacoemulsification on the first postoperative day: to determine the necessity of the first day review
Authors: Seow Sieng Teng , Tajunisah Begam Binti Mohamed Iqbal 
Published: August 2023

Purpose: To establish the type and number of complications detected on the first postoperative day and to determine the necessity of the first day review.
Study design: Clinical audit.
Methods: This is a retrospective review of 297 patients who underwent routine phacoemulsification cataract surgery by qualified ophthalmologists and trainees from September to December 2020 at our day-care operation theatre. All cases of uncomplicated phacoemulsification were analysed for the types and frequency ofcomplications on postoperative day one.
Results: Of 297 cases of routine cataract surgery, 6.7% of cases were excluded due to intraoperative complications. Of the remaining 277 cases, a total of 54 cases (19.5%) were found to have complications on day 1 postoperative review. These included raised intraocular pressure (67.0%), epithelial defect (20.0%), intense inflammation with presence of fibrin (5.0%), retained soft lens matter (4.0%), retained fibres (2.0%), and exposed corneal suture (2.0%). Two patients (0.7%) needed the removal of soft lens matter. Of 36 cases of raised intraocular pressure, 1 patient required anterior chamber paracentesis for retained viscoelastic, 18 patients required topical antiglaucoma medication, 15 patients needed systemic oral acetazolamide, and 2 patients with pre-existing glaucoma were instructed to continue their antiglaucoma medications.
Conclusions: Following uneventful phacoemulsification, only 19.5% of patients were found to have complications on day 1 postoperative review. The most frequent complication was raised intraocular pressure, which can be detected on the day of surgery. Reviewing patients on the same day of surgery can reduce workload and demands on clinician time. It can also significantly reduce health care costs without compromising patient safety.
PRODUCTION OF GREEN DETTOL AS BACTERIAL INHIBITOR AND DISINFECTANT
Authors: Muntaha M. Hadi  , Majid Rasheed Majeed  
Published: August 2023

The aim of this research is production of disinfection (Dettol) contains herbal formula and study the efficacy of it for inhibition of pathogenic bacteria as and comparing with traditional Dettol efficacy. In this research, a herbal disinfectant and antiseptic was prepared similarly to the industrial Dettol and in terms of composition, except for the active substance (chloroxylenol), which was replaced by a plant extract (thyme) and active compound (thymol) separately. total of 50 samples hand swabs were collected randomly from children and housewives and student at university of Baghdad. The following species were isolated from swabs and identified by microscopic morphology, morphological features on culture media, and Vital Index of Traditional Environmental Knowledge(VITEK2)System and that were Staphylococcus aureus, Escherichia.coli, Bacillus cereus ,pseudomonas aeruginosa, Enterobacter cloacae. The results of study showed that the highest antimicrobial activity was belonged to thymol. while a lowest antibacterial effect was belonged to thyme. Highest value of minimum inhibitor concentration (mic) was (0.09) of thymol against staphylococcus aureus while a lowest mic value was (6.25) of thyme against Bacillus cereus the result of minimum bactericidal concertation (mbc) showed that thymol and Dettol were the same value (1.56) against Enterobacter cloacae.
EFFECT OF HERBICIDES ON GROWTH, GRAIN YIELD AND QUALITY OF BARLEY
Authors: Mustafa J. Al-Khafaji  , S. M. A. Safi  , W. F. Hammood  
Published: August 2023

This experiment was aimed to study the effect of herbicide (lintur @180 g.ha-1 + Axial @1.5 L.ha-1, Navigator @ 1.25 L.ha-1 and the control treatment) in the companion weeds. Besides, grain yield and its components of three cultivars of barley (IPA 99, Buhooth 256, Aldebaran). The experiment was carried out according to RCBD, within split plot arrangement using three replicates. The cultivars represented the Main-plots, while herbicides and control treatments represented the sub-plots. The second included a laboratory experiment with four replicates of 50 seeds per replicate to study some grain quality characteristics resulting from the first field experiment. The results were showed the superiority of the Buhooth 256 cultivar in number of spikes, weight of 1000 grains, and the grain yield with an average of 495.10 spike.m-2, 22.23 g, and 1.46 ton.ha-1, respectively. Buhooth 256 also recorded the best results in increasing the percentage of weed control, reducing weed dry weight, and increasing the inhibition ratio. The same cultivar exceeded in most characteristics of grain quality. The treatment of herbicides (lintur + Axial) exceeded by achieving the highest average number of spikes of (471.60 spike.m-2), and the highest number of grains per spike with (51.77 grain.spike-1). Coupled with the weight of 1000 grains (21.47 g), and the highest grain yield (1.53 ton.ha-1).