bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting postoperative gastric cancer prognosis based on inflammatory factors and machine learning technology
Authors: Zhou Cheng-Mao , Wang Ying , Yang Jian-Jun , Zhu Yu 
Published: April 2023

Abstract
Objective
There is a strong association between gastric cancer and inflammatory factors. Many studies have shown that machine learning can predict cancer patients’ prognosis. However, there has been no study on predicting gastric cancer death based on machine learning using related inflammatory factor variables.

Methods
Six machine learning algorithms are applied to predict total gastric cancer death after surgery.

Results
The Gradient Boosting Machine (GBM) algorithm factors accounting for the prognosis weight outcome show that the three most important factors are neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and age. The total postoperative death model showed that among patients with gastric cancer from the predictive test group: The highest accuracy was LR (0.759), followed by the GBM algorithm (0.733). For the six algorithms, the AUC values, from high to low, were LR, GBM, GBDT, forest, Tr and Xgbc. Among the six algorithms, Logistic had the highest precision (precision = 0.736), followed by the GBM algorithm (precision = 0.660). Among the six algorithms, GBM had the highest recall rate (recall = 0.667).

Conclusion
Postoperative mortality from gastric cancer can be predicted based on machine learning.
Development of evidence-based guidelines for the treatment and management of periprosthetic hip infection
Authors: Moore Andrew J. , Wylde Vikki , Whitehouse Michael R. , Beswick Andrew D. , Walsh Nicola E. , Jameson Catherine , Blom Ashley W. 
Published: April 2023

AimsPeriprosthetic hip-joint infection is a multifaceted and highly detrimental outcome for patients and clinicians. The incidence of prosthetic joint infection reported within two years of primary hip arthroplasty ranges from 0.8% to 2.1%. Costs of treatment are over five-times greater in people with periprosthetic hip joint infection than in those with no infection. Currently, there are no national evidence-based guidelines for treatment and management of this condition to guide clinical practice or to inform clinical study design. The aim of this study is to develop guidelines based on evidence from the six-year INFection and ORthopaedic Management (INFORM) research programme.MethodsWe used a consensus process consisting of an evidence review to generate items for the guidelines and online consensus questionnaire and virtual face-to-face consensus meeting to draft the guidelines.ResultsThe consensus panel comprised 21 clinical experts in orthopaedics, primary care, rehabilitation, and healthcare commissioning. The final output from the consensus process was a 14-item guideline. The guidelines make recommendations regarding increased vigilance and monitoring of those at increased risk of infection; diagnosis including strategies to ensure the early recognition of prosthetic infection and referral to orthopaedic teams; treatment, including early use of DAIR and revision strategies; and postoperative management including appropriate physical and psychological support and antibiotic strategies.ConclusionWe believe the implementation of the INFORM guidelines will inform treatment protocols and clinical pathways to improve the treatment and management of periprosthetic hip infection.Cite this article: Bone Jt Open 2023;4(4):226–233.
Impact of insurance status on healthcare resource utilization and outcomes in adolescent patients presenting with spinal cord injuries
Authors: Sandhu Mani Ratnesh S. , David Wyatt B. , Reeves Benjamin C. , Sherman Josiah J. Z. , Craft Samuel , Jayaraj Christina , Boroumand Sam , Clappier Mona , Gutierrez Alan , Sarkozy Margot , Koo Andrew B. , Tuason Dominick A. , DiLuna Michael L. , Elsamadicy Aladine A. 
Published: April 2023

OBJECTIVE
Insurance disparities have been suggested to influence the medical and surgical outcomes of adult patients with spinal cord injury (SCI), with a paucity of studies demonstrating their impact on the outcomes of pediatric and adolescent SCI patients. The aim of this study was to assess the impact of insurance status on healthcare utilization and outcomes in adolescent patients presenting with SCI.

METHODS
An administrative database study was performed using the 2017 admission year from 753 facilities using the National Trauma Data Bank. Adolescent patients (11–17 years old) with cervical/thoracic SCIs were identified using International Classification of Diseases, Tenth Revision, Clinical Modification coding. Patients were categorized by governmental insurance versus private insurance/self-pay. Patient demographics, comorbidities, imaging, procedures, hospital adverse events (AEs), and length of stay (LOS) data were collected. Multivariate regression analyses were used to determine the effect of insurance status on LOS, any imaging or procedure, or any AE.

RESULTS
Of the 488 patients identified, 220 (45.1%) held governmental insurance while 268 (54.9%) were privately insured. Age was similar between the cohorts (p = 0.616), with the governmental insurance cohort (GI cohort) having a significantly lower proportion of non-Hispanic White patients than the private insurance cohort (PI cohort) (GI: 43.2% vs PI: 72.4%, p < 0.001). While transportation accident was the most common mechanism of injury for both cohorts, assault was significantly greater in the GI cohort (GI: 21.8% vs PI: 3.0%, p < 0.001). A significantly greater proportion of patients in the PI cohort received any imaging (GI: 65.9% vs PI: 75.0%, p = 0.028), while there were no significant differences in procedures performed (p = 0.069) or hospital AEs (p = 0.386) between the cohorts. The median (IQR) LOS (p = 0.186) and discharge disposition (p = 0.302) were similar between the cohorts. On multivariate analysis, with respect to governmental insurance, private insurance was not independently associated with obtaining any imaging (OR 1.38, p = 0.139), undergoing any procedure (OR 1.09, p = 0.721), hospital AEs (OR 1.11, p = 0.709), or LOS (adjusted risk ratio −2.56, p = 0.203).

CONCLUSIONS
This study suggests that insurance status may not independently influence healthcare resource utilization and outcomes in adolescent patients presenting with SCIs. Further studies are needed to corroborate these findings.
Grenoble fait ses gammes
Authors: Back Antoine , Guillou Benoît 
Published: April 2023

La Ville de Grenoble s’essaie à l’indicateur du Donut dans le cadre de son plan « Grenoble 2040 ». L’objectif : mettre en place des politiques socio-environnementales soutenables. Entretien avec Antoine Back, adjoint au maire.
Ibest, indicateur de bien-être
Authors: Berthaud Annabelle 
Published: April 2023

La rénovation des Villeneuves, menée par la Métropole de Grenoble, s’appuie sur un indicateur local centré sur le bien-être soutenable : l’Ibest. De quoi démontrer l’impact concret de ces nouvelles méthodes d’évaluation des politiques publiques.
Reflet d’un possible
Authors: Ferren Pascal , Guillou Benoît 
Published: April 2023

Le Parlement de Loire, expérience unique en France, entend doter le fleuve d’une personnalité juridique. Le but : trouver une mécanique politique de la représentation des éléments naturels. Entretien avec Pascal Ferren, l’un des protagonistes de l’initiative.
Role of Pesantren in Improving Sociopreneurs of the Community Around Pesantren in Palembang City
Authors: Asrol Safitri , Hesthria Nur , Rizki Oki Sania 
Published: April 2023

The function of pesantren besides education and da'wah is community empowerment. One of the implementations of the empowerment function is the role of Pesantren in increasing Sociopreneurship in the community around the pesantren. So, this study suggests the role of pesantren in increasing the Sociopreneurship of the Islamic Boarding School Community in Palembang City. This study uses descriptive qualitative research methods and field research methods. Data collection techniques were carried out using observation, and interviews by distributing 30 questionnaires to pesantren administrators and local communities. The study found that social entrepreneurship in pesantren is carried out by providing students with the skills to run a business and collaborate with SMEs (Micro, Small, and Medium Enterprises) to develop businesses. Pesantren also provides economic assistance to socioeconomically disadvantaged populations. The development of Sociopreunership carried out by pesantren has a positive impact on the community around the pesantren, especially in improvement an living standards.
Ferroelectric Polarization‐Enhanced Performance of Flexible CuInP2S6 Piezoelectric Nanogenerator for Biomechanical Energy Harvesting and Voice Recognition Applications
Authors: Zhang Yunchen , Mao Junqi , Zheng Ren‐Kui , Zhang Jiawei , Wu Yonghui , Wang Xiaobing , Miao Kexin , Yao Hongbo , Yang Liya , Zheng Haiwu 
Published: April 2023

Abstract2D piezoelectric materials have strong intrinsic piezoelectricity and superior flexibility, which are endowed with huge potential to develop piezoelectric nanogenerators (PENGs). However, there are few attempts to investigate the energy harvesting of 2D ferroelectric materials. Herein, an enhanced output performance is reported by ferroelectric polarization in a PENG with exfoliated 2D ferroelectric CuInP2S6 (CIPS). Specifically, the polarized CIPS‐based PENG produces a short‐circuit current of 760 pA at 0.85% tensile strain, which is 3.8 times higher than that of unpolarized CIPS‐based PENG. Systematical PFM and Raman analysis reveal that the ferroelectric polarization remarkably reinforces the effective piezoelectric constant of CIPS nanoflakes and boosts the in‐plane migration and out‐of‐plane hopping of copper ions, which is the main reason for the enhancement of output performance. Furthermore, the CIPS‐based PENG can not only be utilized to harvest biomechanical energy such as wrist joints movement, but also exhibits a potential for a voice recognition system integrated with deep learning technology. The classification accuracy of a series of letter sounds is as high as 96%. This study commendably broadens the application scope of 2D materials in micro‐nano energy and intelligent sensors, which will have profound implications for exploring wearable nanoelectronic devices.
Radiofrequency labeling strategies in chemical exchange saturation transfer MRI
Authors: Bie Chongxue , van Zijl Peter , Xu Jiadi , Song Xiaolei , Yadav Nirbhay N. 
Published: April 2023

AbstractChemical exchange saturation transfer (CEST) MRI has generated great interest for molecular imaging applications because it can image low‐concentration solute molecules in vivo with enhanced sensitivity. CEST effects are detected indirectly through a reduction in the bulk water signal after repeated perturbation of the solute proton magnetization using one or more radiofrequency (RF) irradiation pulses. The parameters used for these RF pulses—frequency offset, duration, shape, strength, phase, and interpulse spacing—determine molecular specificity and detection sensitivity, thus their judicious selection is critical for successful CEST MRI scans. This review article describes the effects of applying RF pulses on spin systems and compares conventional saturation‐based RF labeling with more recent excitation‐based approaches that provide spectral editing capabilities for selectively detecting molecules of interest and obtaining maximal contrast.
New late‐emphasis and combination tests based on infimum and supremum logrank statistics with application in oncology trials
Authors: Boher Jean Marie , Filleron Thomas , Bunouf Pierre , Cook Richard J. 
Published: April 2023

AbstractImmunotherapy cancer clinical trials routinely feature an initial period during which the treatment is given without evident therapeutic benefit, which may be followed by a period during which an effective therapy reduces the hazard for event occurrence. The nature of this treatment effect is incompatible with the proportional hazards assumption, which has prompted much work on the development of alternative effect measures of frameworks for testing. We consider tests based on individual and combination of early‐ and late‐emphasis infimum and supremum logrank statistics, describe how they can be implemented, and evaluate their performance in simulation studies. Through this work and illustrative applications we conclude that this class of test statistics offers a new and powerful framework for assessing treatment effects in cancer clinical trials involving immunotherapies.
Monthly Arctic Sea‐Ice Prediction With a Linear Inverse Model
Authors: Brennan M. Kathleen , Hakim Gregory J. , Blanchard‐Wrigglesworth Edward 
Published: April 2023

AbstractWe evaluate Linear Inverse Models (LIMs) trained on last millennium model data to predict Arctic sea‐ice concentration, thickness, and other atmospheric and oceanic variables on monthly timescales. We find that more than 500 years of training data and 100 years of validation data are needed to reliably estimate LIM forecast skill. The best LIM has skill up to 8 months lead time and outperforms an autoregressive model of order one (AR1) forecast at all locations, with particularly large outperformance near the ice edge. However, for out‐of‐sample validation tests using data from various different model simulations and reanalysis products, they underperform an AR1 model due to differences in the location of the sea‐ice edge from the training data. We present a metric for predicting LIM forecast skill, based on the spatial correlation of the variance in the training and validation data sets.
Frizzled-9 activates YAP to rescue simulated microgravity induced osteoblasts dysfunction
Authors: Shi Qiusheng , Gui Jinpeng , Song Yaxin , Na Jing , Zhang Jingyi , Sun Lianwen , Fan Yubo , Zheng Lisha 
Published: April 2023

AbstractLong-term space flight will lead to bone loss and osteoblasts dysfunction. The underlying mechanism is still far to reveal. Frizzled-9 (Fzd9) is a Wnt receptor which is essential to osteoblasts differentiation and bone formation. Here we investigate whether Fzd9 plays a role in simulated microgravity (SMG) induced osteoblasts dysfunction. After 1-3 days of SMG, the osteogenic markers were decreased which accompanied the decline of Fzd9 expression. Fzd9 also decreased in the femur of the rats after 3 weeks of hindlimb unloading. Overexpression of Fzd9 will counteract SMG-induced osteoblasts dysfunction. However, Fzd9 overexpression did not affect SMG induced pGSK3β and β-catenin expression or sublocalization. Overexpression of Fzd9 regulates the phosphorylation of Akt and ERK, as well as induces F-actin polymerization to form the actin cap, presses the nuclei, and increases the nuclear pore size, which promotes nuclear translocation of YAP. Our study provides mechanistic insights into the role of Fzd9 triggers actin polymerization and activates mechano-transducer YAP to rescue SMG-mediated osteoblasts dysfunction and indicates Fzd9 as a potential target to restore osteoblast function in bone diseases and space flight.
The way we live, the way we travel: generation Z and sustainable consumption in food tourism experiences
Authors: Orea-Giner Alicia , Fusté-Forné Francesc 
Published: April 2023

PurposeThis research aims to examine Generation Z's perspectives of sustainable consumption in food tourism experiences, considering the drivers on food tourists' behavioural intents and basing its analysis on the value-attitude-behaviour model of norm activation theory.Design/methodology/approachUsing a qualitative design, 27 qualitative online surveys were conducted with Generation Z travellers who are also active on social media.FindingsResults show that while they are aware of environmental knowledge and ethical food choices and think that sustainable food consumption improves individual and social wellbeing, the sustainability of food consumption is limited by factors such as time and budget. Also, results reveal that the eating habits of Generation Z people are more sustainable when they eat at home than when they travel. Theoretical and practical implications for food tourism management and marketing are described.Originality/valueWhile food tourism has been largely investigated in recent years, little previous research has focused on the relationships between daily eating behaviours and sustainable consumption in food tourism experiences, especially from the perspective of Generation Z individuals and the influence of social media on individual and social food decisions.
Opportunity recognition during the COVID-19 pandemic: a case study of Ghanaian women entrepreneurs in the beauty industry
Authors: Tetteh Sangmorkuor , Mawutor John Kwaku Mensah , Aboagye-Darko Nana Owusua , Boye-Doe Zillah 
Published: April 2023

PurposeThis paper aims to develop insight into the impact the coronavirus disease 2019 (COVID-19) crisis had on female entrepreneurs in Ghana’s beauty industry and their ability to recognize opportunities. The authors also ascertained characteristics of the women that seemed to have influenced opportunity recognition.Design/methodology/approachUsing the case study approach, the authors collected data via in-depth interviews and open-ended questionnaires from sixteen women entrepreneurs in the beauty industry. The data were analyzed using a thematic analysis.FindingsThe data show that women entrepreneurs encountered challenges during the pandemic; however, some of the women were able to identify opportunities. Creativity and social media inclination were perceived to have influenced opportunity recognition. It was also observed from the demographic data that women who identified opportunities and women who could not differ in the level of education, age and firm age.Practical implicationsWomen entrepreneurs are encouraged to capitalize on social media and virtual platforms to enhance their marketing, services and operations. COVID-19 aid for businesses must be distributed equitably to all entrepreneurs in need.Originality/valueThe findings from this study provide novel insights into opportunity recognition during a crisis, focusing on a specific industry in a developing country.
Single‐cell RNA sequencing analysis of a COVID‐19–associated maculopapular rash in a patient with psoriasis treated with ustekinumab
Authors: Rindler Katharina , Tschandl Philipp , Levine Jasmine P. , Shaw Lisa E. , Weninger Wolfgang , Farlik Matthias , Jonak Constanze , Brunner Patrick M. 
Published: April 2023

AbstractCoronavirus disease 2019 (COVID‐19) primarily affects the respiratory system but extrapulmonary manifestations, including the skin, have been well documented. However, transcriptomic profiles of skin lesions have not been performed thus far. Here, we present a single‐cell RNA sequencing analysis in a patient with COVID‐19 infection with a maculopapular skin rash while on treatment with the interleukin (IL)‐12/IL‐23 blocker ustekinumab for his underlying psoriasis. Results were compared with healthy controls and untreated psoriasis lesions. We found the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) viral entry receptors ACE2 and TMPRSS2 in keratinocytes of the patient with COVID‐19, while ACE2 expression was low to undetectable in psoriasis lesions and healthy skin. Among all cell types, ACE2+ keratinocyte clusters showed the highest levels of transcriptomic dysregulation in COVID‐19, expressing type 1–associated immune markers such as CXCL9 and CXCL10. In line with a generally type 1–skewed immune microenvironment, cytotoxic lymphocytes showed increased expression of the IFNG gene and other T‐cell effector genes, while type 2, type 17, or type 22 T‐cell activation was largely absent. Conversely, downregulation of several anti‐inflammatory mediators was observed. This first transcriptomic description of a COVID‐19–associated rash identifies ACE2+ keratinocytes displaying profound transcriptional changes, and inflammatory immune cells that might help to improve the understanding of SARS‐CoV‐2–associated skin conditions.
Cyclic stress response and microcrack initiation mechanism of modified 9Cr‐1Mo steel under low cycle fatigue at room temperature and 350°C
Authors: Shi Shouwen , Cui Jianpeng , Li Haiyan , Chen Gang , Lin Qiang , Chen Xu 
Published: April 2023

AbstractTo investigate the effect of temperature on microcracking mechanisms of modified 9Cr‐1Mo steel, low cycle fatigue tests were performed at 350°C and room temperature (RT). At RT, the cyclic stress response at low strain amplitude (<0.5%) is controlled by friction stress while dominated by back stress at high strain amplitude. By comparison, the disappearance of sub‐grain boundaries induced by dislocation annihilation occurs at 350°C, which contributes to the decrease in back stress, resulting in more significant effects of back stress compared to RT. As a result of the accumulated fatigue damage, the distance between two parallel extrusions at 350°C is larger than that at RT, which is ascribed to the disappearance of low angle sub‐grain boundaries due to dislocation annihilation at 350°C. Due to the disappearance of small‐angle grain boundaries at 350°C, microcracks initiate along high‐angle grain boundaries at 350°C instead of along low‐angle grain boundaries at RT.
New insight of complement system in the process of vascular calcification
Authors: Liu Aiting , Luo Pei , Huang Hui 
Published: April 2023

AbstractThe complement system defences against pathogenic microbes and modulates immune homeostasis by interacting with the innate and adaptive immune systems. Dysregulation, impairment or inadvertent activation of complement system contributes to the pathogenesis of some autoimmune diseases and cardiovascular diseases (CVD). Vascular calcification is the pivotal pathological basis of CVD, and contributes to the high morbidity and mortality of CVD. Increasing evidences indicate that the complement system plays a key role in chronic kidney diseases, atherosclerosis, diabetes mellitus and aging‐related diseases, which are closely related with vascular calcification. However, the effect of complement system on vascular calcification is still unclear. In this review, we summarize current evidences about the activation of complement system in vascular calcification. We also describe the complex network of complement system and vascular smooth muscle cells osteogenic transdifferentiation, systemic inflammation, endoplasmic reticulum stress, extracellular matrix remodelling, oxidative stress, apoptosis in vascular calcification. Hence, providing a better understanding of the potential relationship between complement system and vascular calcification, so as to provide a direction for slowing the progression of this burgeoning health concern.