bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivasi Swadaya dan Semangat Gotong Royong Masyarakat Mengikuti Kampung Bantar di Kota Jambi
Authors: Fahri Sukmal , Nurjanah Nurjanah 
Published: August 2023

Kota Jambi mewujudkan semua kampong baik RT dan Kelurahan mengikuti kegiatan Kampung Bersih, Aman dan Pintar (Bantar) yang melibatkan masyarakat, melalui upaya baik forum maupun kelompok kerja, penelitian ini untuk mengetahui bagaimana peran serta prilaku dan partisipasi masyarakat mengikuti kampung Bantar di Kota Jambi. Metode penelitian deskriptif kualitatif, peneliti melakukan wawancara ke responden tentang perilaku yang telah lalu atau sekarang, berkaitan dengan motivasi dan partisipasi dalam kampung BANTAR, penelitian dilaksanakan di RT 40 Kelurahan Kenali asam bawah Kecamatan Kota Baru Kota Jambi Tahun 2022. Sampel masyarakat RT 40 sampel yang telah dihitung menggunakan rumus slovin sebanyak 105 jiwa. Hasil penelitian peran serta aktif masyarakat dalam mengikuti kampong Bantar sangat tinggi yaitu sebanyak 95% dan prilaku sebanyak 84% serta partisipasi masyarakat sebanyak 96%. Program Kampung Bantar yang berlokasi di RT 40 Kelurahan Kenali asam bawah Kota Jambi, dapat diambil kesimpulan bahwa masyarakat berperan aktif dalam program kampung bantar, Masyarakat juga ikut berpartisipasi dalam program kampung bantar yang diadakan seperti masyarakat yang rutin bergotong-royong setiap minggu, mengikuti ronda malam, membangun sarana prasarana dilingkungan RT serta ikut menjaga kebersihan lingkungan, dan Masyarakat juga berperilaku baik dengan adanya program kampung bantar.Kata Kunci : kampung Bantar, partisipasi, prilaku, peran serta The city of Jambi has realized that all villages, both RT and Kelurahan, participate in the activities of the Clean, Safe and Smart Village (Bantar) which involve the community, through the efforts of both forums and working groups. Qualitative descriptive research method, the researcher conducted interviews with respondents about past or present behavior, related to motivation and participation in the Bantar village. The research was carried out in RT 40, Kenali Asam Bawah Village, Kota Baru District, Jambi City in 2022. Samples of RT 40 samples has been calculated using the slovin formula as many as 105 souls. The results of the research on the active participation of the community in participating in the Bantar village are very high, namely as much as 95% and behavior as much as 84% and community participation as much as 96%. The Kampung Bantar program, which is located in RT 40 Kelurahan Kenali Asam Bawah, City of Jambi, can be concluded that the community plays an active role in the Kampung Bantar program. The community also participates in the Kampung Bantar program which is held as a community that routinely works together every week, takes part in night patrols. , building infrastructure in the RT environment and participating in maintaining environmental cleanliness, and the community also behaves well with the bantar village program.Keywords: Bantar village, participation, behavior, participation
Formulasi Sediaan Tabir Surya Ekstrak Daun Seledri (Apium graveolens L.)
Authors: Meilina Rulia , Dewi Rahma , Kesumawati Kesumawati , Kulla Periskila Dina Kali , Rezeki Sahbainur 
Published: August 2023

Tabir surya merupakan kosmetik pelindung yang memiliki peran yang sangat penting dalam menjaga kesehatan kulit, dari pengaruh buruk paparan sinar matahari. Penelitian ini bertujuan untuk memformulasikan dan mengetahui aktivitas tabir surya dari ekstrak daun seledri. Metode penelitian secara eksperimental laboratorium. Sediaan tabir surya diformulasikan dengan menambahkan ekstrak seledri dengan komposisi 2% (F1), 4% (F2), 6% (F3) dan kontrol negatif. setiap sediaan tabir surya diukur nilai aktivitas tabir surya. Uji aktivitas formulasi menunjukkan bahwa ekstrak daun seledri memiliki aktivitas sebagai tabir surya. Pada F1 sebesar 4,5553 SPF, F2 sebesar 7,3183 SPF, F3 sebesar 8,1573 SPF, sedangkan kontrol negatif tidak menghasilkan daya proteksi. Kesimpulan Formulasi sediaan tabir surya ekstrak daun seledri memiliki aktivitas tabir surya.Kata kunci: Tabir surya, daun seledri, antioksidan, SPFSunscreen is a protective cosmetic that has a very important role in maintaining healthy skin, from the bad effects of sun exposure. This study aims to formulate and determine the activity of sunscreen from celery leaf extract. Laboratory experimental research methods. Sunscreen preparations are formulated by adding celery extract with a composition of 2% (F1), 4% (F2), 6% (F3) and negative control. For each sunscreen preparation, the value of sunscreen activity was measured. Formulation activity test showed that celery leaf extract has activity as a sunscreen. In F1 it was 4.5553 SPF, F2 was 7.3183 SPF, F3 was 8.1573 SPF, while the negative control did not produce any protection. Conclusion The formulation of celery leaf extract sunscreen has sunscreen activity.Keywords: Sunscreen; celery; antioxidants; SPF
OPTIMASI KINERJA MIKROTIK TERHADAP SERANGAN BRUTE FORCE DAN DDOS
Authors: Sayuti M , Gunawan Doni 
Published: August 2023

Abstrak— Serangan суbеr уаng semakin meningkat mеnjаdіkаn реrѕоаlаn bagi реnуеdіа layanan jasa internet. Contoh jenis ѕеrаngаn суbеr yang digunakan аdаlаh dеngаn tеknіk serangan DDoS dаn Brute Fоrсе. Pеrаngkаt jaringan ѕереrtі Mikrotik pun bisa mеnjаdі target dari ѕеrаngаn. Uрауа mencegah serangan dіреrlukаn dеngаn ѕuаtu ѕіѕtеm keamanan. Pеnеlіtіаn ini mеnggunаkаn mеtоdе kuаntіtаtіf dеngаn menganalisis реrfоrmаѕі dаn kіnеrjа dаrі Mіkrоtіk apabila tеrjаdі ѕеrаngаn. Hаѕіl Pеngujіаn, serangan DDos sebanyak 171847 ѕеrаngаn ke port 80 terpantau CPU Mikrotik ѕеbеѕаr 96,81% dаn раdа wеbѕеrvеr ѕеbеѕаr 16,61%. Pеrаngkаt Mikrotik уаng tеlаh terkena ѕеrаngаn DDoS ѕudаh tidak dараt lagi bеrореrаѕі secara nоrmаl. Namun saat ѕkеnаrіо ѕеrаngаn Brute Force, tеrраntu nоrmаl 4,76% раdа CPU Mikrotik kаrеnа роrt fоrwаrdіng telah mеnеruѕkаn раkеt ѕеrаngаn kе ѕеrvеr Hоnеуроt. Kesimpulan dari реnеlіtіаn іnі serangan DDoS dan Brutе Fоrсе mengakibatkan реnіngkаtаn bеbаn kіnеrjа CPU baik раdа Mikrotik mаuрun pada ѕеrvеr Hоnеуроt.Kata kunci: Mikrotik, Brute Force, DDos, ServerAbstract— Increasing суbеr аttасkѕ hаvе become a рrоblеm fоr іntеrnеt ѕеrvісе providers. Exаmрlеѕ оf tуреѕ of суbеr аttасkѕ uѕеd аrе DDoS and Brute Fоrсе attack tесhnіԛuеѕ. Nеtwоrk dеvісеѕ ѕuсh аѕ Mіkrоtіk саn аlѕо become targets of attacks. Effоrtѕ tо рrеvеnt аttасkѕ аrе needed with a security system. Thіѕ rеѕеаrсh uѕеѕ quantitative mеthоdѕ bу аnаlуzіng thе реrfоrmаnсе and performance оf Mіkrоtіk in the еvеnt of аn аttасk. Tеѕt rеѕultѕ, DDоѕ attacks as mаnу as 171847 аttасkѕ оn port 80 monitored bу CPU Mikrotik by 96.81% аnd оn the wеbѕеrvеr bу 16.61%. Mіkrоtіk devices that hаvе bееn hіt bу a DDоS аttасk can nо lоngеr ореrаtе normally. Hоwеvеr, durіng thе Brutе Force attack scenario, nоrmаl 4.76% ѕuрроrtѕ the Mіkrоtіk CPU bесаuѕе роrt fоrwаrdіng hаѕ fоrwаrdеd thе аttасk расkеt to the Hоnеуроt ѕеrvеr. Thе соnсluѕіоn оf this study DDоS аnd Brute Force attacks rеѕultеd in an іnсrеаѕе in thе CPU реrfоrmаnсе load bоth оn Mіkrоtіk and оn thе Hоnеуроt server.Keywords: Mikrotik, Brute Force, DDos, Server
Prevalence of antecedent Kawasaki disease in young adults with suspected acute coronary syndrome in high incidence cohort
Authors: Shyu Tsung-Cheng , Wu Chiung-Jen , Fu Yun-Ching , Peng Yi-Chin , Chuang Tzu-Yao , Kuo Ho-Chang , Hsieh Kai-Sheng , Tai I-Hsin 
Published: August 2023

BackgroundAcute coronary syndrome (ACS) in early adulthood (&lt;40 years old) may be associated with unrevealed diagnoses of Kawasaki disease (KD) in childhood. Daniels et al. showed that 5% of young adults with acute coronary syndrome might have antecedent Kawasaki disease in a cohort with Kawasaki disease incidence rates ranging from about 9 to 20 per 100,000 children under 5 years of age. However, there is no relevant research from the cohort with higher incidence rates (&gt;80–100 per 100,000 children under 5 years of age) of Kawasaki disease.MethodsWe conducted a multicenter, retrospective study by reviewing medical records and angiographic data from two institutions (middle and southern Taiwan, respectively) of adults &lt;40 years of age who underwent coronary angiography for clinically suspected acute coronary syndrome (2009–2019). Angiographic images were independently analyzed by three cardiologists who were blinded to the medical records. Demographic and laboratory data and risk factors of coronary artery disease were integrated to assess the likelihood of antecedent KD.ResultsAll 323 young adults underwent coronary angiography, and 27 had coronary aneurysms. The patients’ clinical and angiographic characteristics were evaluated, and 7.4% had aneurysms likely to be associated with KD. Most subjects were male (23/24), and their low-density lipoprotein (LDL) levels were significantly higher (p = 0.028) than those of subjects unlikely to have KD.ConclusionThis study proposed that the cohort with higher Kawasaki disease incidence rates may have a higher prevalence of young adult ACS associated with antecedent KD. The importance of determining the clinical therapeutic significance of antecedent Kawasaki disease in young adult ACS warrants advanced research. Higher LDL levels may have a long-term cardiovascular impact in KD patients with persistent coronary aneurysms.
Evaluation of cardiovascular toxicity of the atezolizumab and bevacizumab combination
Authors: Niimura Takahiro , Goda Mitsuhiro , Miyata Koji , Matsumoto Jun , Yoshioka Toshihiko , Hamano Hirofumi , Aizawa Fuka , Yagi Kenta , Izawa-Ishizawa Yuki , Zamami Yoshito , Ishizawa Keisuke 
Published: August 2023

Introduction: The combination of atezolizumab, an immune checkpoint inhibitor (ICI), and bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor, is the first choice for systemic therapy in hepatocellular carcinoma. Immune-related cardiovascular toxicity—myocarditis and pericarditis—are known to occur during ICI treatment. By contrast, VEGF inhibitors (VEGFIs) cause cardiovascular complications such as hypertension and heart failure. Thus, different cardiovascular toxicities have been recognized for ICIs and VEGFIs, but the impact of their combination remains unclear. Here, we aimed to investigate the cardiovascular toxicity profile of atezolizumab in combination with bevacizumab using the World Health Organization adverse event reporting database—VigiBase.Methods: We analyzed data included in VigiBase till December 2022. To evaluate the frequency of reports related to atezolizumab, bevacizumab, and their combinations for 21 adverse events, we calculated the reporting odds ratio and information component. Analyses of the fatality of various cardiovascular toxicities associated with the use of each drug were performed.Results: The database included 84,951, 10,595, and 2,092 reports of treatment with bevacizumab, atezolizumab, and their combination, respectively. The disproportionality signal of hypertension, arterial embolism and thrombosis, supraventricular tachyarrhythmias, heart failure, myocarditis, hemorrhage-related clinical events, venous embolism and thrombosis, cardiomyopathy, respiratory failure with combination regimen of atezolizumab and bevacizumab was detected. Signals of these adverse events were also detected treatment with either atezolizumab or bevacizumab alone. Venous embolism and thrombosis exhibited the highest fatality rate in the two drug combination (12.82%) relative to those of atezolizumab (6.19%) and bevacizumab (4.54%).Discussion: Cardiovascular toxicity, owing to the combination of atezolizumab and bevacizumab, was similar to that of each single agent, and no new safety concerns were observed. Caution should be exercised when combining the two drugs since the fatality rate of thromboembolism increases with combination treatment.
Genetically predicted circulating levels of cytokines and the risk of depression: a bidirectional Mendelian-randomization study
Authors: Wang Meiti , Jin Guixiang , Cheng Ying , Guan Shi-Yang , Zheng Jinxin , Zhang Shun-Xian 
Published: August 2023

Objective: Inflammatory cytokines disturbance is the main result of immune dysregulation, which is widely described in major depressive disorder (MDD). However, the potential causal relationship between these two factors has not been discovered. Therefore, the purpose of this study was to investigate the causal relationship between inflammatory cytokines and MDD risk by using the two-sample Mendelian randomization (MR) analysis.Method: Two genetic instruments obtained from publicly available gene profile data were utilized for the analysis. We obtained the genetic variation data of 41 inflammatory cytokines from genome-wide association studies (GWAS) meta-analysis of 8293 individuals of Finnish descent. The MDD data, including 135,458 MDD cases and 344,901 controls, were obtained from the Psychiatric Genomics Consortium Database. For the Mendelian randomization (MR) estimation, several methods were employed, namely, MR-Egger regression, inverse-variance weighted (IVW), weighted median, and MR-Pleiotropy RESidual Sum and Outlier (MR-PRESSO) methods.Result: A causal relationship was identified between the genetically proxied levels of Interleukin (IL) −18, IL-1β, and Regulated upon activation normal T cell expressed and secreted (RANTES) and the risk of MDD (OR = 0.968, 95%CI = 0.938, 0.998, p = 0.036; OR = 0.875, 95%CI = 0.787, 0.971, p = 0.012; OR = 0.947, 95%CI = 0.902, 0.995, p = 0.03; respectively). However, our Mendelian randomization (MR) estimates provided no causality of MDD on inflammatory cytokines.Conclusion: Our study elucidates the connection between inflammatory cytokines and MDD by using MR analysis, thereby enhancing our comprehension of the potential mechanisms. By identifying these associations, our findings hold substantial implications for the development of more effective treatments aimed at improving patient outcomes. However, further investigation is required to fully comprehend the exact biological mechanisms involved.
Machine learning in predicting T-score in the Oxford classification system of IgA nephropathy
Authors: Xu Lin-Lin , Zhang Di , Weng Hao-Yi , Wang Li-Zhong , Chen Ruo-Yan , Chen Gang , Shi Su-Fang , Liu Li-Jun , Zhong Xu-Hui , Hong Shen-Da , Duan Li-Xin , Lv Ji-Cheng , Zhou Xu-Jie , Zhang Hong 
Published: August 2023

BackgroundImmunoglobulin A nephropathy (IgAN) is one of the leading causes of end-stage kidney disease (ESKD). Many studies have shown the significance of pathological manifestations in predicting the outcome of patients with IgAN, especially T-score of Oxford classification. Evaluating prognosis may be hampered in patients without renal biopsy.MethodsA baseline dataset of 690 patients with IgAN and an independent follow-up dataset of 1,168 patients were used as training and testing sets to develop the pathology T-score prediction (Tpre) model based on the stacking algorithm, respectively. The 5-year ESKD prediction models using clinical variables (base model), clinical variables and real pathological T-score (base model plus Tbio), and clinical variables and Tpre (base model plus Tpre) were developed separately in 1,168 patients with regular follow-up to evaluate whether Tpre could assist in predicting ESKD. In addition, an external validation set consisting of 355 patients was used to evaluate the performance of the 5-year ESKD prediction model using Tpre.ResultsThe features selected by AUCRF for the Tpre model included age, systolic arterial pressure, diastolic arterial pressure, proteinuria, eGFR, serum IgA, and uric acid. The AUC of the Tpre was 0.82 (95% CI: 0.80–0.85) in an independent testing set. For the 5-year ESKD prediction model, the AUC of the base model was 0.86 (95% CI: 0.75–0.97). When the Tbio was added to the base model, there was an increase in AUC [from 0.86 (95% CI: 0.75–0.97) to 0.92 (95% CI: 0.85–0.98); P = 0.03]. There was no difference in AUC between the base model plus Tpre and the base model plus Tbio [0.90 (95% CI: 0.82–0.99) vs. 0.92 (95% CI: 0.85–0.98), P = 0.52]. The AUC of the 5-year ESKD prediction model using Tpre was 0.93 (95% CI: 0.87–0.99) in the external validation set.ConclusionA pathology T-score prediction (Tpre) model using routine clinical characteristics was constructed, which could predict the pathological severity and assist clinicians to predict the prognosis of IgAN patients lacking kidney pathology scores.
Association between sedentary behavior and risk of cognitive decline or mild cognitive impairment among the elderly: a systematic review and meta-analysis
Authors: Cai Xiao-ye , Qian Guo-ping , Wang Feng , Zhang Ming-yang , Da Ying-juan , Liang Jing-hong 
Published: August 2023

BackgroundExisting evidence on the association between sedentary behavior (SB) and cognitive function remains inconclusive. Therefore, this study investigated the association between SB and the risk of cognitive decline (CD) or mild cognitive impairment (MCI) in the elderly.MethodsA comprehensive search was independently conducted by two researchers (XC and GQ) in seven electronic databases, including Medline (via PubMed), China Biology Medicine, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang database, and VIP database for Chinese technical periodicals, covering studies published from the inception of database to June 2023. Studies that investigated the relationship between SB and the risk of CD or MCI in the elderly were included. The quality of the literature was assessed using the Newcastle–Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) assessment tools. The combined effect size analysis, subgroup analysis, and publication bias assessment were performed using STATA 14.0.ResultsA total of 13 cross-sectional and 6 cohort studies involving 81,791 individuals were included, comprising 17 high-quality studies and 2 medium-quality studies. We found that SB was significantly associated with an increased risk of CD [odds ratio (OR) = 1.69, 95% confidence intervals (CI): 1.47–1.94] or MCI (OR = 1.34, 95% CI: 1.14–1.56) among the elderly. Subgroup analysis stratified according to comorbidity, lifestyle, family structure, publication year, and region showed statistical differences between groups, and the consistency of the results revealed the sources of the heterogeneity.ConclusionThis meta-analysis showed that SB is positively associated with the risk of CD or MCI in the elderly, providing a higher level of evidence for the promotion of healthy behaviors by clinicians and health policymakers. Due to the number and quality of the included articles, more high-quality longitudinal studies are needed to further confirm our findings.
Otolaryngology-related symptoms of COVID-19 in children in the post-epidemic era: a cross-sectional web-based survey study
Authors: Chen Yong-chao , Wang Xin , Teng Yi-shu , Jia De-sheng , Li Lan , Pan Hong-guang 
Published: August 2023

PurposeChina adjusted and optimized its prevention and control strategies in December 2022, and it entered a new era of the coronavirus epidemic. Here, we describe the general and otolaryngology-related symptoms of coronavirus disease 2019 (COVID-19) in children during the first pandemic in the post-epidemic era, focusing on the frequency and severity of smell and taste loss, as well as the recovery process and its influencing factors.Patients and methodsFrom 2 January to 7 January 2023, we conducted a cross-sectional online questionnaire survey through Questionnaire Stars in order to collect relevant information about COVID-19 in children in Shenzhen.ResultsA total of 1,247 valid questionnaires were received, with an effective response rate of 78.72%. All of the diagnoses were confirmed by nucleic acid or antigen test for COVID-19. Among the subjects, the sex ratio of male to female was more inclined to male (1.35:1), and the age was 3–16 years, with an average of 10.13 ± 2.82 years old. The most common symptoms were cough (58.24%), stuffy nose (56.18%), headache (42.09%), fatigue (40.44%), and sore throat (31.63%). Approximately 6.43% of the children reported dysosmia, the mean time of the duration of dysosmia was 5.38 ± 2.92 days, and the mean score of the severity of the dysosmia as assessed by visual analogue scale (VAS) was 4.63 ± 2.29. Approximately 13.34% reported dysgeusia, the mean time of the duration of dysgeusia was 4.77 ± 3.98 days, and the mean score of the severity of the dysgeusia as assessed by VAS was 5.12 ± 2.29. Univariate and multivariate logistic regression analysis showed that the prevalence of taste and olfactory disorders increased with age, mainly in children with severe symptoms and older children.ConclusionIn the post-epidemic era, due to weakening of the pathogenicity of the subvariant of Omicron, overall condition of children with COVID-19 was mild, incidence of olfactory and taste disorders was low, recovery was faster, and prognosis was better. In our study, cough, runny nose, and sore throat were the most common symptoms, and the prevalence of taste and olfactory disorders increased with age, mainly in older children with severe symptoms.
Reference standards for the 6-min walk test in Croatian older adults
Authors: Sagat Peter 
Published: August 2023

Introduction: The 6-min walk test (6MWT) is commonly used to assess the level of functional capacity of individuals with respiratory diseases. Although previous evidence has provided reference standards for the 6MWT in unhealthy older adults, no data have been provided for the Croatian healthy older populations. Therefore, the main purposes of the study were to define sex- and age-specific references for the 6MWT in older adults.Methods: Six-hundred and forty-three older adults (260 men and 383 women) aged 60–80 years were recruited in this observational cross-sectional study. The participants were instructed to walk the maximal distance possible for 6 min. The main outcome was the final score in the 6MWT conducted at a 30-m straight corridor.Results: Men exhibited longer walking distance, compared to women (678.3 ± 59.1 vs. 653.8 ± 49.9 m, p &lt; 0.001) and younger men and women performed better, than their older counterparts (p &lt; 0.001). However, the sex*age interaction effect showed no significant differences between men and women in the same age range (p = 0.865).Discussion: This is the first study with the purpose of providing reference standards for the 6MWT in a large sample of Croatian older adults. Older men and women in lower percentiles may be treated as a “risky group” of individuals with a special attention of implementing interventions to enhance the performance.