bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic analysis of three forms of Ki‐67 in patients with breast cancer with non‐pathological complete response before and after neoadjuvant systemic treatment
Authors: Zhang Weiwei , Xu Yinggang , Wang Ye , He Jinzhi , Chen Rui , Wan Xinyu , Shi Wenjie , Huang Xiaofeng , Shi Xiaoqing , Wang Jue , Zha Xiaoming 
Published: February 2023

AbstractBackgroundPatients who do not achieve a pathological complete response (pCR) after neoadjuvant systemic treatment (NST) have a significantly worse prognosis. A reliable predictor of prognosis is required to further subdivide non‐pCR patients. To date, the prognostic role in terms of disease‐free survival (DFS) between the terminal index of Ki‐67 after surgery (Ki‐67T) and the combination of the baseline Ki‐67 at biopsy before NST (Ki‐67B) and the percentage change in Ki‐67 before and after NST (Ki‐67C) has not been compared.AimThis study aimed to explore the most useful form or combination of Ki‐67 that can provide prognostic information to non‐pCR patients.Patients and MethodsWe retrospectively reviewed 499 patients who were diagnosed with inoperable breast cancer between August 2013 and December 2020 and received NST with anthracycline plus taxane.ResultsAmong all the patients, 335 did not achieve pCR (with a follow‐up period of ≥1 year). The median follow‐up duration was 36 months. The optimal cutoff value of Ki‐67C to predict a DFS was 30%. A significantly worse DFS was observed in patients with a low Ki‐67C (p < 0.001). In addition, the exploratory subgroup analysis showed relatively good internal consistency. Ki‐67C and Ki‐67T were considered as independent risk factors for DFS (both p < 0.001). The forecasting model combining Ki‐67B and Ki‐67C showed a significantly higher area under the curve at years 3 and 5 than Ki‐67T (p = 0.029 and p = 0.022, respectively).ConclusionsKi‐67C and Ki‐67T were good independent predictors of DFS, whereas Ki‐67B was a slightly inferior predictor. The combination of Ki‐67B and Ki‐67C is superior to Ki‐67T for predicting DFS, especially at longer follow‐ups. Regarding clinical application, this combination could be used as a novel indicator for predicting DFS to more clearly identify high‐risk patients.
Congenital absence of left atrial appendage in a patient with ischemic stroke and atrial fibrillation
Authors: Mayire Aobuli , Jia Li Li , Yasen Nuliya , Zhou Gui‐ming , Du Xin 
Published: February 2023

AbstractLeft atrial appendage (LAA) is a finger‐like muscular extension of the left atrium, and it is the most prominent site for cardiac thrombus in patients with atrial fibrillation. Congenital absence of LAA could be incidentally detected in patient with ischemic stroke and atrial fibrillation. Although it is considered to be an extremely rare cardiac anomaly, its clinical significance remains unknown and there is no clear consensus in the management strategy in those patients. Therefore, we report a case of an incidentally noted congenital absence of LAA in a 68‐year‐old woman being planned for LAA closure.
Enhanced Pomegranate‐Structured SnO2 Electrocatalysts for the Electrochemical CO2 Reduction to Formate
Authors: Daele Kevin Van , Arenas‐Esteban Daniel , Choukroun Daniel , Hoekx Saskia , Rossen Alana , Daems Nick , Pant Deepak , Bals Sara , Breugelmans Tom 
Published: February 2023

AbstractAlthough most state‐of‐the‐art Sn‐based electrocatalysts yield promising results in terms of selectivity and catalyst activity, their stability remains insufficient to date. Here, we demonstrate the successful application of the recently developed pomegranate‐structured SnO2 (Pom. SnO2) and SnO2@C (Pom. SnO2@C) nanocomposite electrocatalysts for the efficient electrochemical conversion of CO2 to formate. With an initial selectivity of 83 and 86 % towards formate and an operating potential of −0.72 V and −0.64 V vs. RHE, respectively, these pomegranate SnO2 electrocatalysts are able to compete with most of the current state‐of‐the‐art Sn‐based electrocatalysts in terms of activity and selectivity. Given the importance of electrocatalyst stability, long‐term experiments (24 h) were performed and a temporary loss in selectivity for the Pom. SnO2@C electrocatalyst was largely restored to its initial selectivity upon drying and exposure to air. Of all the used (24 h) electrocatalysts, the pomegranate SnO2@C had the highest selectivity over a time period of one hour, reaching an average recovered Faradaic efficiency (FE) of 85 %, while the commercial SnO2 and bare pomegranate SnO2 electrocatalysts reached an average of 79 and 80 % FE towards formate, respectively. Furthermore, the pomegranate structure of Pom. SnO2@C was largely preserved due to the presence of the heterogeneous carbon shell, which acts as a protective layer, physically inhibiting particle segregation/pulverisation and agglomeration.
Interactions between Hydrogen and Palladium Nanoparticles: Resolving Adsorption and Absorption Contributions
Authors: Moumaneix Lilian , Rautakorpi Akseli , Kallio Tanja 
Published: February 2023

AbstractDespite the apparent simplicity of palladium hydride systems, interactions between hydrogen and palladium are multifaceted. Electrochemical hydrogen stripping allows measuring the stoichiometric coefficient of hydrogen atoms inside PdHx structures, whose properties greatly depend on x. In this paper, the insertion of H into Pd nanoparticles has been studied in a three‐electrode setup (RDE) and a proton pump cell. An original way of modelling the hydrogen desorption curve is proposed, helping in the separation of hydrogen absorption from other contributions. The loading voltage exhibits the highest impact on the H absorption into Pd, reaching Habs/Pd up to 0.47±0.02 in the RDE setup, at −0.2 VRHE. Conversely, the loading duration presents only little influence in the very first seconds. Finally, maximal Habs/Pd ratios are measured around 30–40 °C, likely due to an optimal balance between the H adsorption rate, and the H diffusion rate into Pd.
Noncovalent interactions on the electrocatalytic oxidation of ethanol on a Pt/C electrocatalyst
Authors: Han Chenjie , Lyu Yeqing , Wang Shaona , Liu Biao , Zhang Yi , Lu Jun , Du Hao 
Published: February 2023

AbstractDue to their environmentally friendly nature and high energy density, direct ethanol fuel cells have attracted extensive research attention in recent decades. However, the actual Faraday efficiency of the ethanol oxidation reaction (EOR) is much lower than its theoretical value and the reaction kinetics of the EOR is sluggish due to insufficient active sites on the electrocatalyst surface. Pt/C is recognized as one of the most promising electrocatalysts for the EOR. Thus, the microscopic interfacial reaction mechanisms of the EOR on Pt/C were systematically studied in this work. In metal hydroxide solutions, hydrated alkali cations were found to bind with OHad through noncovalent interactions to form clusters and occupy the active sites on the Pt/C electrocatalyst surface, thus resulting in low Faraday efficiency and sluggish kinetics of the EOR. To reduce the negative effect of the noncovalent interactions on the EOR, a shield was made on the electrocatalyst surface using 4‐trifluoromethylphenyl, resulting in twice the EOR catalytic reactivity of Pt/C.
Photoswitchable Copper(I) and Copper(II) Complexes of Phenylazo‐3,5‐dimethylpyrazole Incorporated Ligands
Authors: Gupta Debapriya , Gaur Ankit Kumar , Thakur Sandeep Kumar , Singh Sanjay , Venkataramani Sugumar 
Published: February 2023

AbstractWe report the design, synthesis, characterization, and photochemistry of three photoresponsive azoheteroarene‐based neutral N‐donor ligands. Furthermore, those bidentate and tridentate ligands have been coordinated with Cu(I) and Cu(II) metal ions to form seven complexes exhibiting different geometries and nuclearities. Detailed studies of the electronic properties, photoswitching, and thermal reverse isomerization behavior of the photoswitched states of the free ligands and their metal complexes in different solvents are presented.
Interactive effects of maternal physiological arousal and regulation on maternal sensitivity: Replication and extension in an independent sample
Authors: Leerkes Esther M. , Girod Savannah A. , Buehler Cheryl , Shriver Lenka H. , Wideman Laurie 
Published: February 2023

AbstractThis study examined the extent to which mothers’ physiological arousal (i.e., skin conductance level [SCL] augmentation) and regulation (i.e., respiratory sinus arrhythmia [RSA] withdrawal) interacted to predict subsequent maternal sensitivity. Mothers’ (N = 176) SCL and RSA were measured prenatally during a resting baseline and while watching videos of crying infants. Maternal sensitivity was observed during a free‐play task and the still‐face paradigm when their infants were 2 months old. The results demonstrated that higher SCL augmentation but not RSA withdrawal predicted more sensitive maternal behaviors as a main effect. Additionally, SCL augmentation and RSA withdrawal interacted, such that well‐regulated maternal arousal was associated with greater maternal sensitivity at 2 months. Further, the interaction between SCL and RSA was only significant for the negative dimensions of maternal behavior used to derive the measure of maternal sensitivity (i.e., detachment and negative regard) suggesting that well‐regulated arousal is particularly important for inhibiting the tendency to engage in negative maternal behaviors. The results replicate findings from mothers in previous studies and demonstrate that the interactive effects of SCL and RSA in relation to parenting outcomes are not sample specific. Considering joint effects of physiological responding across multiple biological systems may enhance understanding of the antecedents of sensitive maternal behavior.
Transcription factors regulating vasculogenesis and angiogenesis
Authors: Payne Sophie , Neal Alice , De Val Sarah 
Published: February 2023

AbstractTranscription factors (TFs) play a crucial role in regulating the dynamic and precise patterns of gene expression required for the initial specification of endothelial cells (ECs), and during endothelial growth and differentiation. While sharing many core features, ECs can be highly heterogeneous. Differential gene expression between ECs is essential to pattern the hierarchical vascular network into arteries, veins and capillaries, to drive angiogenic growth of new vessels, and to direct specialization in response to local signals. Unlike many other cell types, ECs have no single master regulator, instead relying on differing combinations of a necessarily limited repertoire of TFs to achieve tight spatial and temporal activation and repression of gene expression. Here, we will discuss the cohort of TFs known to be involved in directing gene expression during different stages of mammalian vasculogenesis and angiogenesis, with a primary focus on development.
Support for an area–heterogeneity tradeoff for biodiversity in croplands
Authors: Khan Sara , Fahrig Lenore , Martin Amanda E. 
Published: February 2023

AbstractRapid expansion of the human population poses a challenge for wildlife conservation in agricultural landscapes. One proposal for addressing this challenge is to increase biodiversity in such landscapes by increasing crop diversity. However, studies report both positive and negative effects of crop diversity on biodiversity. One possible explanation, derived from the “area–heterogeneity tradeoff hypothesis,” is that the effect of crop diversity on biodiversity depends on a tradeoff between increasing the number of crop types in a landscape and decreasing the amount of each single crop type. This should cause positive effects of increasing crop diversity at low to intermediate crop diversity and negative effects at intermediate to high crop diversity. We also propose two factors that could change the point at which the effect of increasing crop diversity shifts from positive to negative. First, we predicted that this shift would occur at a lower crop diversity when the surrounding landscape contains less semi‐natural habitat and at a higher crop diversity when the landscape contains more semi‐natural habitat. This should increase the likelihood of detecting negative effects of crop diversity when semi‐natural cover is low and positive effects when it is high. Second, we predicted that the shift from a positive to negative effect would occur at a lower crop diversity when it is measured locally than when it is measured at greater distances from the site, making detection of negative crop diversity effects more likely when measurements are at local extents. We tested these predictions using data on the biodiversity of herbaceous plants, butterflies, syrphid flies, woody plants, bees, carabid beetles, spiders, and birds at 221 crop field edges in Eastern Ontario, Canada. We found support for an area–crop diversity tradeoff. Semi‐natural cover and measurement extent influenced the biodiversity–crop diversity relationship, with positive effects when semi‐natural cover was high and negative effects when semi‐natural cover was low and when crop diversity was measured at local extents. The results suggest that policies/guidelines designed to increase crop diversity will not benefit biodiversity in the landscapes where conservation action is most urgently needed, that is, in landscapes with high agricultural use and low semi‐natural cover.
Hydrological dynamics and associated greenhouse gas fluxes in a mountain peatland under different climate scenarios
Authors: Millar David J. , Cooper David J. , Dwire Kathleen A. , Hubbard Robert M. , Ronayne Michael J. , von Fischer Joseph 
Published: February 2023

AbstractPeatlands have sequestered atmospheric carbon dioxide (CO2) for millennia and can also act as significant sources of atmospheric methane (CH4). Hydrological processes that control water table dynamics, and climatic conditions such as air temperature, play important roles in mediating peatland–atmosphere exchange of these greenhouse gases. These controls are likely to be impacted by climate change, particularly for those peatlands found in cold environments, including mountain regions. In this study, we developed empirical models to simulate hydrological dynamics and ecosystem–atmosphere C exchange in a mountain peatland under three climate scenarios (2012 air temperatures, +2°C and +4°C). Observed water table dynamics and air temperature were used to model ecosystem–atmosphere C exchange during the 2012 growing season. Modelled snowmelt dynamics were used to predict water table position at the beginning of the growing season for warming scenarios, and the subsequent water table dynamics and increased air temperature were used to drive the same C exchange models during the growing seasons. Increased air temperatures led to earlier snowmelt and water table decline, causing water tables to drop by 10 and 19 cm for the +2 and +4°C scenarios, respectively. This led to roughly a two‐fold decrease in growing season net ecosystem production (NEP) in both warming scenarios, as a result of increased ecosystem respiration relative to gross primary production. Methane efflux was positively correlated with NEP and therefore decreased under the warming scenarios, albeit to a lesser degree. These results indicate that reductions in NEP and CH4 efflux are possible in low‐elevation mountain peatlands that are dependent on snowpack‐derived hydrologic inputs. These ecosystems are found at elevations where future winter precipitation will increasingly fall as rain rather than snow and melting of snowpack will occur earlier under warmer conditions.
Airway epithelial type‐2 alarmin profiles: Blood eosinophil counts remain in memory
Authors: Vernisse Charlotte , Tuaillon Edouard , Suehs Carey , Gras Delphine , Bedin Anne Sophie , Charriot Jeremy , Knabe Lucie , Vachier Isabelle , Chanez Pascal , Petit Aurélie , Bourdin Arnaud 
Published: February 2023

AbstractEpithelial cytokines are involved in the orchestration of T1/T2 inflammatory patterns. We question the persistence of this trait in air–liquid interface (ALI) epithelial cultures and whether this local orientation can be related to systemic patterns (e.g., blood eosinophil counts [BECs]). We investigated alarmin release related to high versus low T2 phenotypes associated with chronic airway diseases. ALIs were reconstituted from 32 control, 40 chronic obstructive pulmonary disease, and 20 asthmatic patients. Interleukin‐8 (IL‐8; a T1‐cytokine), IL‐25, IL‐33, and thymic stromal lymphopoietin (T2‐alarmins) concentrations were assessed in subnatants at steady state and used to explain blood neutrophil and eosinophil counts. IL‐25 and IL‐8 levels were highest in asthma ALI‐subnatants, whereas IL‐33 was sparsely detected. Thymic stromal lymphopoietin levels were similar among groups. All asthma cell cultures were T1‐high/T2‐high, while chronic obstructive pulmonary disease and controls tended to be mixed. BECs were independently explained by both disease and in‐culture T2‐alarmin levels, irrespective of the T2‐alarmin considered. The epithelial ALI‐T2 signature was more frequently high in patients with a BEC > 300/mm3. Despite removal from an in vivo environment for ≥2 months, ALIs release disease‐specific cytokine “cocktails” into their subnatants, suggesting continued persistence of alarmin orientation in differentiated cell line environments.
Development of a Measure Cell to Assess by Amperometry Dissolved Oxygen in Vegetable Oils
Authors: Ben Fakhri Ahmad , Artaud Jacques , Cano Gregory , Moulin Philippe 
Published: February 2023

AbstractDissolved oxygen in vegetable oils is an important component of oil degradation over time. Various methods for the determination of dissolved oxygen in oils are proposed in the literature leading to very variable results. An amperometric method associated with a cell of measurement in dynamic mode makes it possible to determine the conditions of stability of the measurements of the relative dissolved oxygen concentration (RDOC, mg L−1) and the electrolysis current intensity (ECI) (nA) in seed oils and virgin olive oils. The effects of oxygenation/deoxygenation time and temperature on RDOC measurements are investigated. For virgin olive oils, the RDOC in bottles closed for eight weeks varies from 0 to 0.9 mg L−1. The nature of the fruitiness and the filtration of the oils have no influence on the RDOC. The monitoring of RDOC and ECI during the flow of virgin olive oil in a column open to air, simulating an industrial tank, shows differences in dissolved oxygen concentration due to a faster flow of oil in the center of the column than at the walls. This result is validated by a similar experiment with nitrogen inerting the column and by a numerical simulation.Practical applications: Knowledge of the oxygen dissolved in vegetable oils is an important factor in limiting the autoxidation phenomenon to increase their shelf life. The development of a cell for measuring the relative dissolved oxygen concentration (RDOC) in vegetable oils and its conditions of use, provides a tool for the RDOC applicable to the different stages of the manufacturing process and during storage or packaging. The RDOC measurement is particularly useful during long storage in tanks whether inerted or not.
Analysis of the relevance of sentiment data for the prediction of excess returns in a multiasset framework
Authors: Desforges Perceval , Geissler Christophe , Liu Fei 
Published: February 2023

AbstractIn this study, we look at the relevance of sentiment data for the prediction of excess returns in a multiasset analysis. We start by initial exploratory data analysis in order to assess the pertinence of the sentiment data. We then compare the performance of rule‐based algorithms with and without the sentiment data. The data considered are provided by RavenPack. Finally, we explore the economic relevance of the forecast model in a long‐only and long‐short context. Inclusion of sentiment data leads to encouraging results.
Modulation of Rac1/PAK1/connexin43‐mediated ATP release from astrocytes contributes to retinal ganglion cell survival in experimental glaucoma
Authors: Zhao Guo‐Li , Zhou Hong , Guo Yun‐Hui , Zhong Shu‐Min , Zhou Han , Li Fang , Lei Bo , Wang Zhongfeng , Miao Yanying 
Published: February 2023

AbstractConnexin43 (Cx43) is a major gap junction protein in glial cells. Mutations have been found in the gap‐junction alpha 1 gene encoding Cx43 in glaucomatous human retinas, suggestive of the involvement of Cx43 in the pathogenesis of glaucoma. However, how Cx43 is involved in glaucoma is still unknown. We showed that increased intraocular pressure in a glaucoma mouse model of chronic ocular hypertension (COH) downregulated Cx43, which was mainly expressed in retinal astrocytes. Astrocytes in the optic nerve head where they gather and wrap the axons (optic nerve) of retinal ganglion cells (RGCs) were activated earlier than neurons in COH retinas and the alterations in astrocytes plasticity in the optic nerve caused a reduction in Cx43 expression. A time course showed that reductions of Cx43 expression were correlated with the activation of Rac1, a member of the Rho family. Co‐immunoprecipitation assays showed that active Rac1, or the downstream signaling effector PAK1, negatively regulated Cx43 expression, Cx43 hemichannel opening and astrocyte activation. Pharmacological inhibition of Rac1 stimulated Cx43 hemichannel opening and ATP release, and astrocytes were identified to be one of the main sources of ATP. Furthermore, conditional knockout of Rac1 in astrocytes enhanced Cx43 expression and ATP release, and promoted RGC survival by upregulating the adenosine A3 receptor in RGCs. Our study provides new insight into the relationship between Cx43 and glaucoma, and suggests that regulating the interaction between astrocytes and RGCs via the Rac1/PAK1/Cx43/ATP pathway may be used as part of a therapeutic strategy for managing glaucoma.