bluuebunny/crossref_metadata_2025_split huggingface dataset:
A determination to the relationship between loneliness and internet addiction among college students based on liquidity preference theory
Authors: Zhang Xinyi , Li Shanshan , Yang Haijun , Guo Xianhong , Yang Min , Wei Sha , Wang Yan , Huang Xing , Huang Juan , Zhao Jiahao , Zhang Yanmei 
Published: May 2023

Abstract
Background Nowadays, Internet addiction is becoming increasingly popular among college students, causing great harm to their physical and mental health. More and more researchers pay attention to Internet addiction. However, the influencing factors of it were not clear. This study aimed to explore the influencing factors, then explained it with liquidity preference theory, hoping our findings might provide theoretical basis for preventing Internet addiction.Methods A total of 2355 college students were randomly selected to complete questionnaires consisted of sociodemographic data, UCLA Loneliness Scale, and Internet Addiction Test from 2021 to 2022 in Wuhan, China. The multivariable linear and logistic regressions were conducted to explore the influencing factors of Internet addiction.Results In this survey, the prevalence of internet addiction was 33.7% (794/2355). According to the multiple linear regression analysis, low level of satisfaction in school and professional satisfaction, the experience of childhood maltreatment, and the high level of loneliness were risk factors for Internet addiction. However, age and grade were the protective factors for Internet addiction. Graduate students had lower rates of Internet addiction than undergraduates. In the fully corrected model multiple logistic regression analysis, students with average and high levels of loneliness had 1.84 times and 4.83 times the risk of Internet addiction compared with individuals with low levels of loneliness.Conclusion Students with high levels of loneliness were at higher risk for Internet addiction. Perhaps we could reduce the loneliness of students by organizing more group activities, so as to reduce the rate of Internet addiction.
Co-creation of the Global Patient Experience Data Navigator: A multi-stakeholder initiative to ensure the patient voice is represented in health decision-making
Authors: Willgoss Tom , Escontrias Omar A. , Scrafton Carole , Oehrlein Elisabeth , Livingstone Victoria , Chaplin Fiona C. , Benivento Maddalena , Chapman Hayley , Brooke Nicholas 
Published: May 2023

Abstract
Background Putting patients’ needs and priorities at the forefront of healthcare initiatives and medical product development is critical to achieve outcomes that matter most to patients. This relies on the integration of early, meaningful patient engagement (PE) to learn what is important to patients, and collection of representative patient experience data (PXD). The increased number of PE/PXD efforts across global regulatory, health technology assessment, and healthcare systems is an important step forward to deliver improved health outcomes for patients. However, these initiatives are fragmented and lack integration, which is necessary to maximize efforts and reduce burden on patients. To overcome these challenges, the Global Patient Experience Data Navigator has been co-created by Patient Focused Medicines Development to provide practical resources that can facilitate and optimize PXD generation, collection, analysis, and dissemination for patient benefit and aims to be applicable across all therapeutic areas for all stakeholders.Methods Co-creation of the Navigator took place through an iterative process of validation and formalization driven by a diverse, multi-stakeholder working group with individuals who have varying knowledge/experience in PE/PXD. A series of workshops took place to conduct a gap analysis, develop a taxonomy model, and integrate existing frameworks.Results The collective insights led to the development of the Navigator consisting of four specific tools in the form of downloadable templates, which can be used to: (1) prioritize outcomes that matter most to patients and their caregivers; (2) select appropriate measurement methods for these outcomes; (3) identify when and why PXD is used throughout the product development cycle for each stakeholder; (4) identify when and why PXD is used throughout the healthcare process for each stakeholder. A public consultation was carried out to collect user feedback before the Navigator was made publicly available in December 2022.Conclusion To our knowledge, the Global Patient Experience Data Navigator is the only publicly available toolkit developed with a multi-stakeholder and disease-agnostic approach providing taxonomically grouped resources to optimize the collection and collation of PXD for patient benefit. Future work will aim to further engage patients by adding a PE dimension to the Navigator.
Combination of Health Care Service Use and the Relation to Demographic and Socioeconomic Factors for Patients With Musculoskeletal Disorders: A Descriptive Cohort Study
Authors: Amundsen Olav , Moger Tron Anders , Holte Jon Helgheim , Haavaag Silje Bjørnsen , Bragstad Line Kildal , Hellesø Ragnhild , Tjerbo Trond , Vøllestad Nina Køpke 
Published: May 2023

Abstract
BACKGROUND Patients with musculoskeletal disorders (MSDs) access health care in different ways. Despite the high prevalence the significant costs associated with the disorders, we know little about the different ways patients use health care. We aim to fill this gap by identifying what combinations of health care services patients use for new MSD in Norway, and discuss possible implications of this variation.METHODS The study combines Norwegian registers on health care use, diagnosis, comorbidities, demographic and socioeconomic factors. Patients (≥ 18 years) are included by their first health consultation for MSD in 2013–2015. Latent class analysis (LCA) with count data of first year consultations for GP, hospital, physiotherapy and chiropractor are used to identify combinations of health care use. Long-term high-cost patients are defined as total reimbursement costs year 1–5 above 95th percentile (≥ 3 744€).RESULTS We identified seven classes: 1: GP, low use; 2: GP, high use; 3: GP and hospital; 4: GP and physiotherapy, low use; 5: GP, hospital and physiotherapy, high use; 6: Chiropractor, low use; 7: GP and chiropractor, high use. Median first year health care contacts varied between classes from 1 to 30 and costs from 20€ to 838€. Eighty-seven percent belonged to class 1, 4 or 6 with low use of health care resources. Classes with high use were characterised by higher age, lower education and more comorbidity and were overrepresented among the long-term high-cost users.CONCLUSION There were a large variation in first year health care service use, and we identified seven latent classes based on frequency of use of different health care services. A low proportion of patients accounts for a high proportion of total resource use. The classes showed considerable differences in demographic and socioeconomic factors, highlighting the significance of these factors for how patients use health care services for their MSDs. These findings contributes to the understanding of clinical pathways for patients with MSD and can help in planning of future care. More research is required to determine whether the observed variations are due to lack of equity in health care delivery or differences in patient-needs.
Oral Microbiome Diversity Predicts All-cause Mortality in the General Population: A Prospective Population-based Cohort Study
Authors: Yang Zhiwen , he Fengling , Xu Junyang , Cui Kai , Ruan Yifei , Zhou HuiLei , Zhou JiaJun , Liu Dan , Xiao Zhiwen , Chen Guojun , Liao Yulin , Bin Jianping , Chen Yanmei 
Published: May 2023

Abstract
Background Increasing evidence suggests a potential link between oral microbiome diversity and the occurrence of multiple chronic extraoral diseases. However, evidence regarding oral microbiota diversity and long-term prognosis in the general population is limited. This prospective study aimed to investigate whether oral microbiome diversity is associated with all-cause mortality in the general population.Results During a mean follow-up period of 8.9 years, 429 deaths occurred. After multivariate adjustment, a negative association was observed between oral microbiome α diversity and all-cause mortality (P < 0.01). Significant differences in all-cause mortality risk were observed between the different clusters based on the oral microbiome β diversity (Log-rank P < 0.001). Subgroup analyses revealed that oral microbiome diversity was independently associated with all-cause mortality in individuals with extraoral diseases, particularly those with diabetes mellitus and hypertension. A multivariate logistic regression model demonstrated that increased dietary fiber intake and reduced antibiotic use were significantly associated with higher oral microbiome α diversity.Conclusions Higher oral microbiome diversity was significantly associated with a lower risk of all-cause mortality in the general population and in individuals with extraoral diseases, especially diabetes mellitus and hypertension. Reasonable restrictions on antibiotic use and high dietary fiber intake may increase oral microbiome diversity, thereby reducing the risk of all-cause mortality.
Sociodemographic and Clinical Characteristics of Treated and Untreated Adults with Bulimia Nervosa and/or Binge-eating Disorder Recruited for a Large-Scale Research Study
Authors: Carrino Emily , Flatt Rachael , Pawar Pratiksha , Sanzari Christina , Tregarthen Jenna , Argue Stuart , Thornton Laura , Bulik Cynthia , Watson Hunna 
Published: May 2023

Abstract

Background:Eating disorders affect millions of people worldwide, but most never receive treatment. The majority of clinical research on eating disorders has focused on individuals recruited from treatment settings, which may not represent the broader population of people with eating disorders. This study compared the characteristics of individuals with eating disorders based on whether they self-reported accessing treatment or not, to identify potential differences and contribute to a better understanding of the diverse needs and experiences of individuals with eating disorders.Methods:The study population included 762 community-recruited individuals (85% female, M ± SD age = 30 ± 7 y) with bulimia nervosa and/or binge eating disorder (BN/BED) enrolled in the Binge-Eating Genetics Initiative (BEGIN) United States study arm. Participants completed self-report surveys on demographics, treatment history, past and current eating disorder symptoms, weight history, and current mental health and gastrointestinal comorbidity. Untreated participants (n= 291, 38%) were compared with treated participants (n= 471, 62%) who self-reported accessing BN/BED treatment at some point in their lives.Results:Untreated participants disproportionately self-identified as male and as a racial or ethnic minority compared with treated participants. Treated participants reported a more severe illness history, specifically, an earlier age at onset, more longstanding and frequent ED symptoms over their lifetime, and higher body dissatisfaction and comorbid mental health symptoms (i.e., depression, anxiety, ADHD) at the time of the study. Those who reported a history of inpatient or residential treatment displayed the most severe illness history, whereas those who reported outpatient treatment had a less severe illness history, and untreated individuals had the mildest illness history.Conclusions:Individuals from historically overlooked or marginalized populations were less likely to access treatment. Those who accessed treatment had more severe ED and comorbid symptoms, which may have motivated them to seek treatment. Clinic-based recruitment samples may not accurately represent all individuals with EDs, particularly those with milder symptoms and those with gender or racial/ethnic diversity. The results of this study indicate that community-based recruitment is crucial for improving the ability to apply research findings to broader populations and to reduce disparities in medical research.TrialRegistration: ClinicalTrials.gov NCT04162574 (https://clinicaltrials.gov/ct2/show/NCT04162574)
D-Xylose, a Stimulator of Heparan Sulfate Biosynthesis, Exhibits Antiviral Properties Against SARS-CoV-2, ZIKV, HCMV and HIV-1 NL4-3 In Vitro
Authors: Cheudjeu Antony 
Published: May 2023

Abstract
Background
Primary human cytomegalovirus (HCMV) infection can be especially serious in pregnant women and cause severe consequences for newborns. We aimed to determine which metabolites, among the thousands in human sera, are strongly correlated with serious outcomes for pregnant women with HCMV. During the early stage of the pandemic, it was predicted that COVID-19 severity is correlated with serum D-xylose/xylitol levels, which has now been confirmed in two studies.
Methods
Between July 2022 and February 2023, four antiviral assays were performed by Virology Research Services Ltd. to test the antiviral activities of D-xylose, a small bioactive molecule, alone or in combination with insulin against HCMV in HFF, HIV-1 NL4-3 in HeLa TZM-bl, and ZIKV African strain and SARS-CoV-2 England strain separately in VeroE6, with incubation durations of 5 days, 48 h, 48 h and 72 h post-infection, respectively. Ganciclovir, 3′-Azido-3′-deoxythymidine (AZT), monensin and remdesivir were used as controls. An immunofluorescence method was used for readouts of all viruses except for SARS-CoV-2, for which CPE was considered. Cytotoxicity was assessed by an MTT assay.
Results
The results show that D-xylose exhibits antiviral activities against SARS-CoV-2, ZIKV, HCMV and HIV-1 in vitro, with preliminary selectivity indices of 11.6, 1.6, 2.1 and 2.6, respectively. Thus, D-xylose is more effective over a broader range of concentrations against HCMV and SARS-CoV-2 than against ZIKV and HIV-1. The EC50 value (in mM) for different assays must be placed in perspective; the average serum concentration of D-xylose in a healthy person is approximately 1.8 Mm.
Conclusions
The properties of the cell-layer HS stimulated by D-xylose and especially unfractionated heparin (UFH)—another antiviral compound against these viruses—combined with these results challenge the conclusion that HS promotes viral infections.
Trial Registration
Not Applicable.
Can Bangladesh bring back the green cover through indigenous species plantation?
Authors: Rahman Md Mizanur 
Published: May 2023

Abstract

Per capita forestland in Bangladesh is declining at an alarming rate. The recurrent anthropogenic disturbances have rendered the natural forests inhospitable for the natural regeneration and growth of wild plant associates, causing a net loss of biodiversity. Instead of native species plantation, exotic species have become an increasingly important source of timber, which negatively impacts the natural habitats. Hence, the study explored different options for native species plantation based on habitat types and the level of degradation. It is revealed that natural succession is suitable for increasing the canopy coverage in natural forest areas. In the core and buffer zones of each forest natural regeneration should be facilitated to maintain the ecological balance and to ensure continuous forest coverage. In addition, direct seeding in the buffer zone and degraded forest areas can improve the naturalness. Advanced regeneration of rare or endangered species can protect the species from extinction. Very fast-growing and timbering native species should be planted in the encroached areas. The deep-rooted species can reinforce riverbanks against erosion better than the shallow-rooted ground cover. Trees with large canopies and deep roots can protect the coastal belt. Screw pine (Pandanus) can grow on dunes and has thick ‘prop roots’ to anchor itself in the loose sand. Tanguya plantation should consist of growing annual crops along with forest trees during the early establishment of forest plantations on the hills. Fast-growing and timbering trees can increase the green cover in the fallow land. The ornamental trees simultaneously can increase the green cover and beauty in urban areas.
Study the effects of flotation agents on ABS – PS flotation
Authors: Fagkaew Pattarasiri , Chawaloesphonsiya Nattawin , Painmanakul Pisut 
Published: May 2023

Abstract
The use of appropriate flotation agents is mandatory to effectively separate plastic mixtures with analogous physicochemical characteristics by flotation. In this study, both virgin and post-consumer ABS and PS plastics were chosen as research objects to investigate the effects of flotation agents in ABS – PS flotation and an appropriate condition was then identified for effective separation. The wetting behaviors of wetting agents on ABS and PS surfaces were further studied. As a result, TA demonstrated better selective performance than LS in ABS – PS flotation due to its selective wettability on the ABS surface, referring to a greater surface free energy and a stronger repulsive interfacial interaction. Additionally, laureth-5 was found to be used potentially as a frother in ABS – PS flotation as well as MIBC; however, its application was limited at high concentrations due to its tendency to rapidly reduce surface tension. These findings suggest that the selection of a suitable frother for ABS – PS flotation should not only consider the ability to produce fine bubbles and stabilize the froth but also the ability to reduce the surface tension of the liquid medium. Overall, high recovery and purity of both virgin and post-consumer ABS – PS flotation were achieved by more than 90% under the conditions of TA concentration of 5 mg/L, MIBC concentration of 5 mg/L, and conditioning time of 15 minutes.
Lactylome analyses suggest systematic lysine- lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia
Authors: Song Fan , Hou Chen , Liang Jianfeng , Cai Hongshi , Tian Guoli , Jiang Yaoqi , Wang Ziyi , Qiu Danqi , Hou Jinsong 
Published: May 2023

Abstract

Background Intracellular lactate is shown to drive a novel type of post-translational modification (PTM), lysine lactylation (Kla), which has been confirmed to affect the malignant progression of tumors such as hepatocellular carcinoma (HCC) and gastric cancer. However, the systemic lactylome profiling of oral squamous cell carcinoma (OSCC) is still unclear.Methods In this study, we utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to conduct the quantitative lactylome analyses in OSCC cell line under normoxia and hypoxia. Then, bioinformatics analyses were applied to reveal the conserved motif sequences and enrichment pathways. What’s more, Immunoprecipitation and western blotting verified the results of lactylome.Results The integrative lactylome and proteome analyses identified 1011 Kla sites within 532 proteins and 1197 Kla sites within 608 proteins in SCC25 cells under normoxic and hypoxic environments, respectively. Among these lactylated proteins, histones accounted for only a small fraction, suggesting the presence of Kla modification in large number of non-histones proteins. Notably, Kla prefers to enrich in spliceosome, ribosome and glycolysis/gluconeogenesis pathway in both normoxic and hypoxic cultures. Compared with normoxia, 231 differentially lactylated proteins with 334 differentially lactylated sites were detected under hypoxia, which were mainly associated with glycolysis/gluconeogenesis pathway by KEGG analysis. Importantly, we verified the presence of lactylation in spliceosomal proteins SF3A1 and hnRNPA1 as well as the glycolytic enzyme PFKP.Conclusion Our study is the first report to elucidate the lactylome and its biological function in OSCC, which deepens our understanding of the mechanisms underlying OSCC progression and provides a novel strategy for targeted therapy for OSCC.
ANOVA-based analysis using MATLAB for Groundwater quality assessment
Authors: S Shankar B , Arcot Usha 
Published: May 2023

Abstract
The study involves an ANOVA-based analysis using MATLAB to detect the quality of groundwater in Bellandur area in Bengaluru, Karnataka. The main purpose of this study is to ascertain the suitability of water for drinking and domestic uses. In this work, water samples were collected from thirty groundwater sampling locations of Bellandur, in two (pre-monsoon and post-monsoon seasons) of 2020. Student’s t-test and one way ANOVA are performed using MATLAB version 2015a for key physico-chemical characteristics of water. Six major parameters of water are considered, for which the testing of hypothesis has been carried out employing t-test and analysis of variance. In both the cases, after the hypothesis test was conducted and it was observed that the calculated values were not within the acceptance region. The p-value of the anova table shows that it is above the significance level which hypothize that the differences between the means are not statistically significant. This infers that the water is not potable as it falls outside the permissible limits as prescribed by Bureau of Indian Standards (BIS). Karl Pearson’s coefficient of correlation was calculated for the six parameters of the collected samples, and a positive correlation was observed, ranging from 0.7 to 0.9 for total hardness and chloride, total dissolved solids, and nitrate, chloride and TDS as well as nitrate and TDS.
Synthesis of Novel Methylsulfonylacrylimidamide via Click Chemistry approach, Computational analysis and α- glucosidase inhibition activity
Authors: Surve Santosh Kumar , Birmule Pramod R. , Sankpal Sandeep A. , Patil Sandeep. B. , Kalalawe Virbhadra G. , Salunke-Gawali Sunita , Hangirgekar Shankar 
Published: May 2023

Abstract
A series of Novel Methylsulfonylacrylimidamide analogs (4a – 4h) were designed, synthesized, and screened for their α-glucosidase inhibitory activity. The results indicated that some of the synthesized derivatives displayed inhibitory activities against α-glucosidase with IC50 values ranging from 10.35 ± 0.15 to 60.39 ± 1.77 µM when compared to standard drug acarbose (IC50 832.22 ± 2.00 µM). Among the synthesized derivatives, compounds 4f & 4h with a dicyclohexyl and dioctyl substitution in the acrylimidamide displayed the most significant inhibitory activity with the IC50 value of 14.54 ± 0.19 µM and 10.35 ± 0.15 µM. The inhibitory action of compounds 4f and 4h against α-glucosidase was studied by enzyme kinetic and molecular docking. In vitro, cytotoxicity showed that 4f and 4h exhibited low cytotoxicity against human cell lines. The ADME study suggested that most compounds will likely be orally active as they obeyed Lipinski's rule of five. Our studies showed that these derivatives could be considered a new class of α-glucosidase inhibitors.
Assessing the Role of Morticulture in biodiversity conservation in Bangladesh
Authors: Rahman Md Mizanur 
Published: May 2023

Abstract

Deadwood plays a critical role in the functioning of forest ecosystems and maintaining biodiversity. The deadwood in the forests of Bangladesh is almost absent due to the scarcity of fuelwood. On the other hand, biodiversity loss occurs in Bangladesh at an alarming rate. The study aimed to assess how deadwood can enrich biodiversity in Bangladesh. Based on the respondents' perceptions, it was revealed that deadwood conservation in the natural habitats can increase the abundance of chickadees, Streak-breasted Woodpecker, Fairy bluebirds, leafbirds, common kestrels, magpie robins, Bay woodpeckers, Chestnut-bellied Nuthatch, etc. The endangered small mammals and amphibians can be increased through morticulture. Simultaneously, the decayed deadwood adds organic matter to the forest soil which in turn promotes the natural succession of many plant species. With the support of the key informants, approaches for deadwood conservation in Bangladesh were developed.