bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collaborative Management to support sustainable Community Forest
Authors: Yatim Hertasning , Yusran Yusran , Supratman  , Zaman Nur 
Published: January 2023

Abstract
The current state of social forestry, including community forestry (HKm) in Indonesia, is practically stagnant. Many factors cause stagnation in HKm management, including the main one being the interaction with the Forest Management Unit (FMU) as forest manager at the site level. This study aims to build an institutional model for sustainable forest management through analysis of the arena of action, community attributes, and forest management rules at the Nambo Community Forest, Central Sulawesi. The results of this research found that the collaborative management model between the government and the community is suitable to be applied in Community Forest management, because it provides greater opportunities for recognizing the rights of local communities to forest resources, as well as increasing the empowerment of rural communities.
A study on the hot workability of a novel TNM-RE alloy (RE = Y, La, Ce)
Authors: Chen Zhanxing , Ma Tengfei , Xing Qiuwei , Li Guoju , Zhang Xinzhe , Zhang Xinfang 
Published: January 2023

Abstract
The hot deformation behavior of a novel TNM-RE alloy (RE = Y, La, Ce) was studied using a hot simulation machine (Gleeble-3800), and microstructural evolution was also characterized. Finally, 3D forging was carried out on isothermal forging equipment. It is shown that the as-cast lamellar colony size is about 20 ∼ 30 μm, which is refined by the formation of rare Earth oxides and borides at grain boundaries inhibiting grain growth. The peak stress of the TNM-RE alloy deformed at 1200 °C/0.01 s−1 is about 97 MPa, which is governed by the lamellar colony size and the B2 phase. Based on microstructure observation, it is found that the lamellar is bent and elongated to coordinate plastic deformation, where dynamic recrystallization nucleates preferentially, and full dynamic recrystallization is obtained at 1220 °C/0.01 s−1. The TNM-RE alloy was forged by 3D isothermal forging method, and fine grains with a size of 10 ∼ 20 μm were obtained by controlling the process parameters. The novel TNM-RE alloy shows an excellent hot workability.
Molecular dynamics study on the effects of nanorolling processes on the properties of nickel-based superalloy GH4169
Authors: Yu Fang , Li Jiachun 
Published: January 2023

Abstract
Rolling is a process that can improve the performance and roughness of machined parts and has a special economic value; therefore, the optimization of rolling process parameters is crucial to workpiece performance. In this paper, three rolling methods are used in molecular dynamics (MD) rolling simulations to study their effects on the surface of nickel-based superalloy GH4169 at the nanoscale. The surface and subsurface of the workpiece after rolling with the three different rolling methods are studied separately; in particular, a comparative analysis of the dislocation generation and movement on the subsurface, crystal defect evolution, and surface roughness was performed. The results show that the increase in subsurface dislocation density by average rolling has a significant influence on the work hardening effect, and the average roughness of the rolled groove surface is the lowest. This is an important reference for the optimization of the parameters of actual rolling processes.
A bioinspired modular soft robotic arm
Authors: Hernandez-Barraza Luis , Kalil-Khan Ahmed , Yeow Raye Chen-Hua 
Published: January 2023

Abstract
A human arm is a vital instrument for performing various tasks. To imitate natural design, we developed and characterized a bioinspired modular soft robotic arm fabricated from fabric thermoplastic polyurethane (TPU). The soft robotic arm comprises three link sections, three joints, and an end-effector. Although some soft robotic arms have been designed, they are primarily fabricated with continuous shapes. Therefore, we fabricated a modular and customizable soft robotic arm with different requirements, allowing fast fabrication, prototyping, and assembly, and comprising joint and link sections that can be incorporated together to form an arm with an adjustable number of joints. An analytical approach was used to model the different bending angles at diverse pressures, and a data-driven approach was used to model the angular position with respect to the pressure. Forward and inverse kinematics were performed to calculate the orientation, position, and joint angle of each component. The results showed that the maximum bending angles for each corresponding joint were generally larger for joints number one and three but smaller for joint number two. Moreover, motion analysis data showed that each joint exhibited different bending patterns. Our bio-inspired arm design demonstrated that it could conduct diverse motions at various pressures, in contrast to the soft arms seen in the literature. Additionally, the modular construction of the arm allows it to access larger workplaces, and a gripper should be included in future versions to increase the arm’s capabilities.
Finite-time correlations boost large voltage angle fluctuations in electric power grids
Authors: Tyloo Melvyn , Hindes Jason , Jacquod Philippe 
Published: January 2023

Abstract
Decarbonization in the energy sector has been accompanied by an increased penetration of new renewable energy sources in electric power systems. Such sources differ from traditional productions in that, first, they induce larger, undispatchable fluctuations in power generation and second, they lack inertia. Recent measurements have indeed reported long, non-Gaussian tails in the distribution of local voltage frequency data. Large frequency deviations may induce grid instabilities, leading in worst-case scenarios to cascading failures and large-scale blackouts. In this article, we investigate how correlated noise disturbances, characterized by the cumulants of their distribution, propagate through meshed, high-voltage power grids. For a single source of fluctuations, we show that long noise correlation times boost non-Gaussian voltage angle fluctuations so that they propagate similarly to Gaussian fluctuations over the entire network. However, they vanish faster, over short distances if the noise fluctuates rapidly. We furthermore demonstrate that a Berry–Esseen theorem leads to the vanishing of non-Gaussianities as the number of uncorrelated noise sources increases. Our predictions are corroborated by numerical simulations on realistic models of power grids.
Atlantis Restored
Authors: Wennerlind Carl 
Published: January 2023

Abstract
After success in the Thirty Years’ War, elites in Sweden realized that the nation had to establish a new economic base to support its newfound geopolitical prominence. Drawing on the Pan-European natural-knowledge-based political economy, Swedish reformers developed a version uniquely applicable to the nation’s challenges and opportunities. At the center of this new political economy was the use of scientific knowledge to transform nature into usable wealth. Whether physics, alchemy, mechanics, or botany, any form of knowledge with the power to transform nature through mining, agriculture, or manufacturing was considered valuable. Drawing on either Paracelsian spiritual ideas or those of Cartesian materialism, Swedish improvement thinkers sought to penetrate deep into the inner life of nature and thereby unlock the storehouse of wealth that God had placed therein. This article traces how Johan Risingh, Urban Hiärne, Christopher Polhem, and Carl Linnaeus, in conversation with foreign improvers, combined knowledge of the natural world with commercial considerations to form a discourse they hoped would enable Sweden to embark on a trajectory of economic growth and thereby restore its mythical glory as the cradle of European civilization.
TIVAN-indel: a computational framework for annotating and predicting non-coding regulatory small insertions and deletions
Authors: Agarwal Aman , Zhao Fengdi , Jiang Yuchao , Chen Li 
Published: January 2023

Abstract

Motivation
Small insertion and deletion (sindel) of human genome has an important implication for human disease. One important mechanism for non-coding sindel (nc-sindel) to have an impact on human diseases and phenotypes is through the regulation of gene expression. Nevertheless, current sequencing experiments may lack statistical power and resolution to pinpoint the functional sindel due to lower minor allele frequency or small effect size. As an alternative strategy, a supervised machine learning method can identify the otherwise masked functional sindels by predicting their regulatory potential directly. However, computational methods for annotating and predicting the regulatory sindels, especially in the non-coding regions, are underdeveloped.

Results
By leveraging labeled nc-sindels identified by cis-expression quantitative trait loci analyses across 44 tissues in Genotype-Tissue Expression (GTEx), and a compilation of both generic functional annotations and large-scale epigenomic profiles, we develop TIssue-specific Variant Annotation for Non-coding indel (TIVAN-indel), which is a supervised computational framework for predicting non-coding regulatory sindels. As a result, we demonstrate that TIVAN-indel achieves the best prediction performance in both with-tissue prediction and cross-tissue prediction. As an independent evaluation, we train TIVAN-indel from the ‘Whole Blood’ tissue in GTEx and test the model using 15 immune cell types from an independent study named Database of Immune Cell Expression. Lastly, we perform an enrichment analysis for both true and predicted sindels in key regulatory regions such as chromatin interactions, open chromatin regions and histone modification sites, and find biologically meaningful enrichment patterns.

Availability and implementation
https://github.com/lichen-lab/TIVAN-indel

Supplementary information
Supplementary data are available at Bioinformatics online.
321 Cancer risk with topical pimecrolimus and tacrolimus for atopic dermatitis: systematic review and Bayesian meta-analysis
Authors: Chu Alexandro W L , Devasenapathy Niveditha , Wong Melanie , Srivastava Archita , Ceccacci Renata , Lin Clement , MacDonald Margaret , Wen Aaron , Steen Jeremy , Levine Mitchell , Pyne Lonnie , Wang Julie , Spergel Jonathan M , Silverberg Jonathan I , Ong Peck Y , O’Brien Monica , Martin Stephan A , Lio Peter A , Lind Mary Laura , LeBovidge Jennifer , Kim Elaine , Huynh Joey , Greenhawt Matthew , Frazier Winfred T , Chen Lina , De Benedetto Anna , Boguniewicz Mark , Asiniwasis Rachel N , Schneider Lynda , Chu Derek K 
Published: January 2023

Abstract
Atopic dermatitis affects millions worldwide and is effectively managed by topical treatments, including topical calcineurin inhibitors, pimecrolimus and tacrolimus. In 2005 and 2011, the FDA released reviews associating topical calcineurin inhibitors with a theoretical cancer risk, albeit an uncertain association. We systematically reviewed the risk of cancer in patients with atopic dermatitis exposed to topical calcineurin inhibitors. We systematically identified randomized controlled trials, comparative, and non-comparative non-randomized studies from database inception to 6 June 2022, from MEDLINE, EMBASE, GREAT, LILACS, ICTRP, FDA, EMA, company registers and relevant citations. We included studies in any language addressing the risk of cancer in patients with atopic dermatitis exposed to topical calcineurin inhibitors for greater than 3 weeks. We excluded split-body studies. We conducted a Bayesian meta-analysis and used the GRADE approach to determine the certainty of the evidence. A multidisciplinary panel including patients, advocacy groups and care providers, set an a priori threshold of 1 in 1000 risk difference as a clinically important effect. We analysed 121 studies (52 randomized controlled trials and 69 non-randomized studies) including 3.4 million patents followed for a mean of 11 months (range: 0.7–120). The absolute risk of any cancer with topical calcineurin inhibitor exposure was neither different from controls (absolute risk 4.70 per 1000 with topical calcineurin inhibitor exposure vs. 4.56 per 1000 without; odds ratio 1.03 [95% credible interval 0.94–1.11], moderate-certainty evidence) nor the general US population (4.6 per 1000). Findings were similar in infants, children, and adults, and were robust to trial sequential, subgroup and sensitivity analyses. Among infants, children and adults with atopic dermatitis, moderate-certainty evidence shows that topical calcineurin inhibitors do not increase the risk of cancer. These findings support the safe use of topical calcineurin inhibitors in the management of patients with atopic dermatitis. Our findings provide actional information to inform updated clinical practice guidelines, product labels and continuing education for care providers, to clarify the safe usage of topical calcineurin inhibitors.
331 Prior treatment usage in patients with atopic dermatitis initiating dupilumab: an update from the GLOBOSTAD registry
Authors: Ferrucci Silvia M , Rossi Mariateresa , Fomina Daria S , Lapeere Hilde , Chung Wen-Hung , Tzellos Thrasyvoulos , Fougerousse Anne-Claire , Wu Jiangming , Bosman Kwinten , Ardeleanu Marius 
Published: January 2023

Abstract
The efficacy and safety of dupilumab have been reported previously based on data from controlled clinical trials. The GLOBOSTAD study extends the scope of these trials by providing real-world data. This analysis reports prior treatment usage in patients with atopic dermatitis (AD) initiating treatment with dupilumab in a real-world setting. This 5-year, international, multicentre, non-interventional study (GLOBOSTAD; NCT03992417) included patients ≥12 years-old with moderate-to-severe AD (Investigator’s Global Assessment score ≥3) who initiated dupilumab treatment based on country-specific prescribing information. Data reported are for the population at baseline (N = 952, data cut-off: March 2022). At the study entry, the mean (standard deviation) Patient-Oriented Eczema Measure (POEM) score was 19.7 (6.4). POEM range is 0–28 and scores greater than 17 are consistent with severe or very severe disease. The mean (standard deviation) pruritus on the 0–10 Numerical Rating Scale (NRS) at study entry was 6.3 (2.1). Patient use of systemic treatments such as non-steroidal immunosuppressants (32.6%) and systemic corticosteroids (17.8%), as well as non-systemic treatments such as topical corticosteroids (47.2%) and calcineurin inhibitors (14.8%) in the 12 months preceding enrolment were reported. Ultraviolet phototherapy in the past 12 months was reported for 3.4% of patients. Patient-reported outcomes, including POEM and pruritus NRS, indicate a considerable burden of disease in patients with AD initiating dupilumab in the real world. A large proportion of patients from GLOBOSTAD reported the use of AD-specific systemic and non-systemic therapies prior to dupilumab initiation.
Digital technology in informed consent for surgery: systematic review
Authors: Kiernan Aoife , Fahey Brian , Guraya Shaista S , Boland Fiona , Moneley Daragh , Doyle Frank , Harkin Denis W 
Published: January 2023

Abstract

Background
Informed consent is an ethical and legal requirement in healthcare and supports patient autonomy to make informed choices about their own care. This review explores the impact of digital technology for informed consent in surgery.

Methods
A systematic search of EBSCOhost (MEDLINE/CINAHL), Embase, Cochrane Central Register of Controlled Trials and Web of Science was performed in November 2021. All RCTs comparing outcomes of both digital and non-digital (standard) consent in surgery were included. Each included study underwent an evaluation of methodological quality using the Cochrane risk of bias (2.0) tool. Outcomes assessed included comprehension, level of satisfaction and anxiety, and feasibility of digital interventions in practice.

Results
A total of 40 studies, across 13 countries and 15 surgical specialties were included in this analysis. Digital consent interventions used active patient participation and passive patient participation in 15 and 25 studies respectively. Digital consent had a positive effect on early comprehension in 21 of 30 (70 per cent) studies and delayed comprehension in 9 of 20 (45 per cent) studies. Only 16 of 38 (42 per cent) studies assessed all four elements of informed consent: general information, risks, benefits, and alternatives. Most studies showed no difference in satisfaction or anxiety. A minority of studies reported on feasibility of digital technology in practice.

Conclusion
Digital technologies in informed consent for surgery were found to have a positive effect on early comprehension, without any negative effect on satisfaction or anxiety. It is recommended that future studies explore the feasibility of these applications for vulnerable patient groups and busy surgical practice.
Sex differences in the evaluation and outcomes of multi-ethnic asian patients undergoing stress echocardiography
Authors: Seah C H X , Lau J K X , Li T Y W , Tiong C Y , Poh K K , Sia C H , Wong R C C , Kong W K F 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background/Introduction
Stress echocardiography is an important test used in the evaluation of myocardial ischemia. Despite this, not much is known about sex differences between men and women undergoing stress echocardiography, with regards to their characteristics and outcomes, especially in the Asian population.

Methods
We performed a retrospective cohort study of 1504 consecutive patients evaluated with dobutamine or exercise stress echocardiography performed for suspected coronary artery disease (CAD) or to evaluate the status of known CAD. We divided the patients into two groups: males and females. The tests were classified as positive, equivocal, or negative for ischemia, and the outcomes at 6 months follow-up was analysed.

Results
48.1% (723) patients were males. The mean age of patients was 52.2 ± 14.9 years for males and 55.8 ± 12.5 years for females. The 3 most common indications for stress echocardiography in both males and females were for the assessment of symptoms for suspected CAD in 787 (52.3%), for the assessment of a prior abnormal test in 408 (27.1%) and for the assessment of the status of pre-existing CAD in 93 (6.2%). In terms of co-morbidities, males were more likely to have ischemic heart disease (&lt;0.001), prior AMI (p&lt;0.001), prior PCI (p&lt;0.001) and CABG (p=0.002). Stress echocardiography was normal in 608 men (84.3%) and 643 women (82.3%). A positive result on stress echocardiography was obtained in 65 men (9.0%) and 63 women (8.1%), and equivocal result in 48 men (6.7%) and 75 women (9.6%). During a mean follow-up of 7.9 ± 0.2 years, 84 men (11.6%) and 44 women (5.6%) (p&lt;0.001) experienced a cardiac event, of which there were 40 (2.7%) deaths, with 26 men (3.6%) and 14 women (1.8%) (p=0.030). 26 men (3.6%) and 6 women (0.8%) (p&lt;0.001) experienced an acute myocardial infarction.
Independent predictors of cardiac events in patients using a Cox proportional hazards regression analysis were age (hazard ratio (HR): 1.05 [range 1.03 to 1.07]), female gender (HR: 0.50 [range: 0.328 to 0.760]) and previous myocardial infarction (HR: 2.50 [range 1.28 to 4.86])

Conclusion
Differences in mean age, prevalence of ischemic heart disease, prior myocardial infarction and prior PCI/CABG were noted between males and females who underwent stress echocardiography. Males experienced a higher incidence of cardiac events compared to females. Gender is an independent predictor of cardiac events in patients undergoing stress echocardiography, together with age and a history of myocardial infarction.
Unraveling the invisible demon: a study of the oxidative stress markers, antioxidant activities and inflammatory markers in patients admitted with complete heart block
Authors: Chaudhary G , Pradhan A K , Shah S , Roy S , Singh V , Dwivedi S K , Sethi R , Chandra S , Vishwakarma P , Sharma A K , Bhandari M , Shukla A , Singh A 
Published: January 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Introduction
Despite the recent advancements in the management of Complete Heart Block (CHB), the aetiology of CHB is still idiopathic in most of the cases. Our study explores this hitherto untouched aspect of complete heart block.

Purpose
We aimed to assess the aetiological profile of Complete Heart Block patients in our study.

Methods
The study population consisted of 60 patients with complete heart block aged between 30 to 80 years, attending as an inpatient in ER. Oxidative stress was measured by serum MDA, serum GSH, serum Catalase activity and serum SOD activity. Antioxidant activity was obtained by measuring the levels of serum total antioxidant capacity. Inflammatory stress was measured by IL-5 and TNF-alpha levels. These values were compared to 30 healthy controls with no prior history of smoking and diabetes mellitus.

Results
The mean age of the patient was 62.48 ± 7.98 years and the gender distribution was 37 males and 23 females out of 60 patients. The mean value of serum MDA (ng/mL) in cases is 1451.26 ± 206.32, and in controls, the mean value is 1197.98 ± 234.71 (p=&lt;0.001). The mean value of serum GSH (mcg/mL) in cases is 46.982 ± 18.613, and in controls, the mean value is 54.155 ± 10.762 (p=0.027). The mean value of serum Catalase Activity (U/min/mg protein) in cases is 10.763 ± 4.038 and in controls, the mean value is 19.878 ± 7.787 (p=0.003). The mean value of serum SOD Activity (U/g) in cases is 24.950 ± 5.4565, and in controls, the mean value is 46.214 ± 14.6309 (p=0.891). The mean value of serum Total Antioxidant Capacity (U/mL) in cases is 5.546 ± 0.620 and in controls, the mean value is 8.346 ± 2.781 (p=0.025). The mean value of serum IL-5 (pg/mL) in cases is 481.442 ± 28.8995, and in controls, the mean value is 67.347 ± 20.445 (p&lt;0.001). The mean value of serum TNF-ALFA (pg/mL) in cases is 196.741 ± 73.771, and in controls, the mean value is 144.530 ± 42.599 (p= 0.081).

Conclusions
During a complete heart block, SOD (p=0.891), CAT (p=0.003), GSH (p=0.027) and total antioxidant (TAOC) (p=0.025) were significantly decreased in cases, compared to healthy controls, thus suggesting that the elevated levels of oxidative free radicals causes endothelial dysfunctioning. The increase in ROS was observed by a highly significant increase of malondialdehyde (MDA) (p=&lt;0.001) showing high ROS-mediated tissue damage. Besides damage by oxidative stress, our study suggests that there are certain inflammatory markers like TNF-α and IL-5 that actively participate in causing heart block. There was a significant increase in the concentration of IL-5 (p&lt;0.001) in the cases as compared to the controls.