bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipogenic and SWAT cells separate from a common progenitor in human brown and white adipose depots
Authors: Palani Nagendra P. , Horvath Carla , Timshel Pascal N. , Folkertsma Pytrik , Grønning Alexander G. B. , Henriksen Tora I. , Peijs Lone , Jensen Verena H. , Sun Wenfei , Jespersen Naja Z. , Wolfrum Christian , Pers Tune H. , Nielsen Søren , Scheele Camilla 
Published: June 2023

AbstractAdipocyte function is a major determinant of metabolic disease, warranting investigations of regulating mechanisms. We show at single-cell resolution that progenitor cells from four human brown and white adipose depots separate into two main cell fates, an adipogenic and a structural branch, developing from a common progenitor. The adipogenic gene signature contains mitochondrial activity genes, and associates with genome-wide association study traits for fat distribution. Based on an extracellular matrix and developmental gene signature, we name the structural branch of cells structural Wnt-regulated adipose tissue-resident (SWAT) cells. When stripped from adipogenic cells, SWAT cells display a multipotent phenotype by reverting towards progenitor state or differentiating into new adipogenic cells, dependent on media. Label transfer algorithms recapitulate the cell types in human adipose tissue datasets. In conclusion, we provide a differentiation map of human adipocytes and define the multipotent SWAT cell, providing a new perspective on adipose tissue regulation.
A multi‐device user authentication mechanism for Internet of Things
Authors: Eman Raihan Dewon , Jahan Mosarrat , Kabir Upama 
Published: June 2023

AbstractThe advent of the Internet of Things (IoT) enables different customized services to ease the day‐to‐day life activities of users by utilizing information attained through the internet connectivity of low‐powered sensing devices. Due to device diversity and resource constraints of participating devices, IoT is vulnerable to security attacks. Consequently, authentication is the fundamental measure for using IoT services in the context of network security. IoT devices’ resource captivity makes designing robust and secure authentication mechanisms challenging. Besides, existing user authentication mechanisms are designed assuming a user always accesses an IoT environment using a particular device. However, nowadays, most users employ multiple devices to access the internet; subsequently, it needs an authentication mechanism to handle this diversity. This paper addresses this limitation and proposes a new One‐Time Password (OTP)‐based user authentication scheme supporting user access from multiple devices in an IoT environment. We verify the proposed scheme using widely used BAN logic, AVISPA tool, and informal security analysis, guaranteeing that our scheme preserves the necessary security features. Comparative performance analysis shows that our scheme achieves comparable computation, storage, and communication costs concerning existing works. Moreover, simulation results demonstrate that the proposed method also sustains satisfactory network performance.
Vorstellung eines Patienten mit Rothmund-Thomson-Syndrom mit einer Transformation eines myelodysplastischen Syndroms in eine akute myeloische Leukämie
Authors: Özbaş Hasan Mücahit , Çinar Esma , Oğuz Işıl Deniz , Baylan Alev Gül , Çubukcu Damla , Dikbaş Oguz 
Published: June 2023

ZusammenfassungDas Rothmund-Thomson-Syndrom (RTS) ist eine seltene, autosomal-rezessiv vererbbare Genodermatose mit ungefähr 300 Fallberichten. Es tritt mit einem charakteristischen Gesichtsausschlag als Leitsymptom im Kindesalter auf, der sich zu einer typischen Poikilodermie entwickeln kann. Es besteht eine Prädisposition für Erkrankungen am Auge und für die Entstehung von Osteosarkomen. Darüber hinaus sind in diesem Zusammenhang eine progressive Leukopenie und eine chronische, mikrozytäre, hypochrome und transfusionserfordernde Anämie bekannt. Allerdings finden sich in der Literatur lediglich drei Fallberichte über das myelodysplastische Syndrom (MDS), wobei keiner über eine Transformation in eine akute myeloische Leukämie (AML) berichtet.Anhand dieser Fallvorstellung werden wir detailliert darstellen, wie die Diagnose des RTS gestellt wurde, über den langen klinischen Verlauf berichten, die Entwicklung in ein MDS und die Transformation in eine AML sowie den Behandlungsverlauf erläutern.Diese Fallvorstellung soll Ärzten/-innen bei Patienten mit diagnostiziertem RTS helfen, frühzeitig die Entwicklung von AML zu erkennen.
Balneo- und Hydrotherapie bei rheumatischen Erkrankungen
Authors: Lange Uwe , Schulz Nils , Klemm Philipp 
Published: June 2023

ZUSAMMENFASSUNGBei rheumatischen Erkrankungen hat sich die Balneo- und Hydrotherapie über Jahrhunderte empirisch bewährt. Die Therapieziele fokussieren auf die Schmerzreduktion, die muskuläre Entspannung, die Erhöhung der Muskelkraft und die Verbesserung der funktionellen Mobilität sowie die Verbesserung des Wohlbefindens, der Lebensqualität und eine Senkung des Medikamentenverbrauchs. Der Einsatz balneotherapeutischer Anwendungen wird im Statement des American College of Rheumatology als essenzielle komplementäre Therapieform empfohlen. Ziel der vorliegenden Übersichtsarbeit ist, das aktuelle Wissen über die Wirkungen der Balneo- und Hydrotherapie darzulegen und mögliche Wirkmechanismen bei verschiedenen rheumatischen Erkrankungen aufzuzeigen.
Possible Rates of Detection of Neonatal Sepsis Pathogens in the Context of Microbiological Diagnostics in Mothers – Real World Data
Authors: Kuld Raffael , Krauth Alexander , Kühr Joachim , Krämer Janine , Dittrich Ralf , Häberle Lothar , Müller Andreas 
Published: June 2023

AbstractThe aim of this study was to identify the rate of detection of neonatal sepsis pathogens
in maternal microbiological smears.This is a retrospective study conducted at a Level 1 perinatal center in the context of
routine care from 2014 to 2019. For all premature infants and neonates with neonatal sepsis,
the neonatal and maternal microbiological findings were examined to see if there was a
match.During the study period, a total of 948 premature or newborn infants were identified as
having a neonatal infection. Among all of the premature or newborn infants, 209 (22%) met
the diagnostic criteria for neonatal sepsis; of these, 157 were premature births and 52 were
full-term births. We evaluated the microbiological findings for these 209 mother and child
pairs. No pathogens were detected in 27 out of 157 mothers of premature infants (17.1%) and
in 31 out of 52 mothers of full-term infants (59.6%). In the premature infant group there
were pairs with matching pathogens in 30 out of 130 cases (23.1%, 95% CI: 16.1–31.3), and in
the full-term infant group there was a match in 4 out of 21 cases (19%, 95% CI: 5.4–41.9).
The number needed to test to have a 90% probability of success for pathogen detection varies
between 9 and 11 in the most favorable case and 26 and 32 in the least favorable case,
depending on the evaluation method.In cases of neonatal sepsis, the sepsis-causing pathogen was successfully detected
through prior analysis of a maternal smear in 7% of full-term infants and in 19% of
premature infants. The number needed to test was relatively high in all groups. The value of
maternal smears for identifying neonatal sepsis-causing pathogens needs to be critically
questioned.
A Study on Enumeration of Factors Prone to the Development of COVID-19-Associated Mucormycosis
Authors: Velusamy Sivakumar , Rajagopal Jayakumar , Jayakumar Jessica , Parthiban Dharshini , Hussain Adeeb Ismail Zahir 
Published: June 2023

Abstract
Background Patients with pre-existing chronic medical conditions with altered immunity are prone to COVID-19-associated mucormycosis (CAM).
Objective In this study, our objectives were to identify the risk factors that increase the chances of developing CAM and to determine the severity of the risk factors of CAM. Thereby, we can optimize the modifiable risk factors for developing CAM in coronavirus disease 2019 (COVID-19) patients. For instance, better control of blood glucose levels in COVID-19 patients can decrease the risk of developing CAM.
Materials and Methods The data was collected retrospectively from 1000 COVID-19 infected patients, above the age of 18 years during the time period of March 2021 to August 2021, in which 86 patients had confirmed CAM.
Statistical Analysis Binary logistic regression and curve estimation analysis were performed using SPSS software version 29 for identifying the associated risk factors of CAM with the significance of p-value less than 0.05.
Results Factors such as severe inflammation (p = 0.048), high dose of steroid administration (p = 0.005), increasing age (p < 0.001), and prolonged hospital stay (p < 0.001) were statistically proven to be significant risk factors, associated with CAM.
Conclusion Increasing age, severe inflammation, high dose of steroid administration, and prolonged hospital stay have association with occurrence of CAM.
Anti-M Alloimmunization following Term Stillbirth: A Case Report and Review of the Literature
Authors: Beck Manisha M. , V. Hamsavardhini , Navaneethan Preethi , Kumar Manish 
Published: June 2023

AbstractAlloimmunization due to anti-M antibodies are rare since they present as naturally occurring immunoglobulin M antibodies, which do not cross the placenta. Very rarely, these may convert to immunoglobulin G antibodies and cause hemolytic disease of the fetus and newborn. We present the case of a fifth gravida, with previous two miscarriages and an unexplained stillbirth, booked with us for the 8 weeks. At booking, she was found to have anti-M antibodies with titers of 1:2, which was stable throughout pregnancy. At 35 weeks, there was evidence of severe fetal anemia and features of hydrops on the ultrasound scan, requiring delivery. Neonatal direct Coombs test was positive. Baby had a hemoglobin of 8.8 mg/dL and a reticulocyte count of 5.5% at birth, requiring two units of blood transfusion. He also required 6 days of intensive phototherapy. Alloimmunization due to anti-M antibodies should be suspected in women with previous bad obstetric history. The maternal antibody titers may not be a true reflection of the severity of fetal affection, and hence not reliable for monitoring in pregnancy
Prenatal Diagnosis and Fetal Sonographic Features of Swyer Syndrome
Authors: Kane Daniel T. , Dempsey Mark A. , Burke Annette L. , Morrison John J. 
Published: June 2023

AbstractSwyer syndrome, also known as complete gonadal dysgenesis, is characterized by an individual who has an XY karyotype but is phenotypically female. It is typically diagnosed in adolescence after investigations for primary amenorrhea. The estimated prevalence is 1 in 20,000 to 80,000 births. Mutations in the DNA-binding region of the SRY gene account for approximately 15 to 20% of cases, with the remaining cases caused by other gene mutations. There are no reports of the established diagnosis of Swyer syndrome prenatally, or of the sonographic features that may be associated with it. This report outlines the details of a 33-year-old primigravida in whom a fetal cystic hygroma was noted on ultrasound at 12 weeks gestation. Chorionic villous sampling revealed a diagnosis of fetal Swyer syndrome. The fetus progressed to develop severe fetal hydrops and a parental decision for termination of pregnancy was made at 15 weeks of gestation.
Climate change adaptation responses and human mobility in the Mekong Delta: local perspectives from rural households in An Giang Province, Vietnam
Authors: Bayrak Mucahid Mustafa , Van Hieu Tran , Tran Thong Anh , Hsu Yi-Ya , Nien Tung , Quynh Dang Thi Thanh 
Published: June 2023

AbstractClimate change influences the adaptation responses and mobility patterns of smallholder farmers across multiple scales. This study employed an inductive approach to observe smallholder farmers in An Giang Province in the Vietnamese Mekong Delta to compare the effects of various environmental and climate-related stressors on households with and without contributing migrant household members and on households of different income levels in two rural communes. We looked into the roles that adaptation responses and human mobility patterns play in the daily livelihoods of (translocal) households. We adopted a mixed-methods approach, which involved the administration of a livelihood survey among households in two rural communes (N = 106) and, subsequently, two focus group discussions, unstructured in-depth interviews, and secondary data analysis. We discovered that human mobility, adaptation responses, and climate change are interwoven in a web of complex relationships. No clear differences in effects and climate adaptation responses were discovered between emigrant and nonemigrant households. Hence, paradigms that either portray migration as a failure to adapt or as a form of adaptation in the context of climate change do not adequately explain the findings of this study. Differences between income groups were, however, observed. Relative to other income groups, middle-income farmers were disproportionally affected by climate-related disasters. Additionally, out-migration, aging, upstream hydropower development, and COVID-19 lockdowns posed significant challenges to the livelihoods of smallholder farmers. The compound effects of these multiple stressors indicate that human mobility, climate change and adaptation patterns should be best approached as ‘wicked’ problems.
Analysis of mortars with old plastering waste using state-of-the-art method: nuclear magnetic resonance
Authors: Saitis C , Manea D L , Fechete R , Plesa L M , Saitis L 
Published: June 2023

Abstract
One of the major problems we face today is the correct management of waste generated in all spheres of activity. Thus, the concept of sustainable development aims to develop strategies that prevent and solve problems already generated. Domain construction is the one that generates the most waste worldwide, according to recent studies, which requires the imposition of clear, effective, and future-proof measures to improve the environment and the health of the population. This paper is the continuation of a research program in which 3 types of mortar recipes are analyzed. The study involves replacement of aggregates, in different percentages (10% and 15%), with plaster waste from historic buildings. The obtained results show that the values fall within the limits stipulated in the norms in force, so the study will continue with the analysis of the samples using the state-of-the-art method: nuclear magnetic resonance. The paper aims to analyze the properties of the proposed mortars at the nanoscopic level, following the relationship between the plaster mortar matrix and the plaster waste introduced in different percentages in the samples. In addition, the impact of these wastes on the hydration of the cement and on the porosity of the composition of these mortars is also observed, being noticed that the relationship between the porosity of the samples and the mechanical resistances is inversely proportional, that is, the resistances decrease as the porosity increases. It will also be identified the location of hydrogen in the structure: in hydrated mineralogical compounds of cement and in large, medium and small pores. For each studied sample, the investigations were conducted at the age of 7, 14 and 28 days (even at 3 days for samples with 10% and 15% substitution of aggregates with old plastering mortars). The results for the proposed samples will be compared to the standard recipe.
Identification method of unbalanced fault characteristics of horizontal shaft of rotary table of drilling rig
Authors: Wang Z , Lu C Q , Ma J , Du S Y 
Published: June 2023

Abstract
The horizontal shaft of rotary table is an important rotating part of drilling rig. The vibration caused by the mass imbalance of the horizontal shaft will seriously affect the normal operation of drilling rig and lead to faults. Therefore, taking the horizontal shaft rotor system of rotary table of the drilling rig as the research object, the unbalanced vibration characteristics of the rotor are extracted by the improved all-phase fast Fourier transform method. Through the cross-correlation operation of the signal, the data of the discrete signal is weighted and superimposed, the vibration amplitude, time delay of the phase and the spectrum analysis can be obtained. The experimental results show that the accuracy and stability of the vibration amplitude and phase extracted by the improved all-phase fast Fourier transform method are better, and the accuracy of the vibration phase extraction can reach 98%, which verifies the effectiveness of the proposed method.
The influence of variability on fire weather conditions in high latitude regions under present and future global warming
Authors: Lund Marianne T , Nordling Kalle , Gjelsvik Astrid B , Samset Bjørn H 
Published: June 2023

Abstract
Recent years have seen unprecedented fire activity at high latitudes and knowledge of future wildfire risk is key for adaptation and risk management. Here we present a systematic characterization of the probability distributions (PDFs) of fire weather conditions, and how it arises from underlying meteorological drivers of change, in five boreal forest regions, for pre-industrial conditions and different global warming levels. Using initial condition ensembles from two global climate models to characterize regional variability, we quantify the PDFs of daily maximum surface air temperature (SATmax), precipitation, wind, and minimum relative humidity (RHmin), and their evolution with global temperature. The resulting aggregate change in fire risk is quantified using the Canadian Fire Weather Index (FWI). In all regions we find increases in both means and upper tails of the FWI distribution, and a widening suggesting increased variability. The main underlying drivers are the projected increase in mean daily SATmax and decline in RHmin, marked already at +1 and +2 °C global warming. The largest changes occur in Canada, where we estimate a doubling of days with moderate-or-higher FWI between +1 °C and +4 °C global warming, and the smallest in Alaska. While both models exhibit the same general features of change with warming, differences in magnitude of the shifts exist, particularly for RHmin, where the bias compared to reanalysis is also largest. Given its importance for the FWI, RHmin evolution is identified as an area in need of further research. While occurrence and severity of wildfires ultimately depend also on factors such as ignition and fuel, we show how improved knowledge of meteorological conditions conducive to high wildfire risk, already changing across the high latitudes, can be used as a first indication of near-term changes. Our results confirm that continued global warming can rapidly push boreal forest regions into increasingly unfamiliar fire weather regimes.
Echocardiographic findings in COVID: incidence of carditis and correlations with COVID variants
Authors: Fazio G , Manfre V 
Published: June 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also referred to as COVID-19, was declared a pandemic by the World Health Organization in March 2020. The manifestations of COVID-19 are widely variable and range from asymptomatic infection to multi-organ failure and death. Like other viral illnesses, acute myocarditis and/or pericarditis has been reported to be associated with COVID-19 infection. The guidelines for the diagnosis of COVID-19 introduced the echocardiogram for diagnosis of carditis in these patients

Pourpose
In our study we investigated the incidences of myocarditis and/or pericarditis in a consecutive series of 1540 Athletes undergo to agonistic certification.

Methods
From march 2020 to October 2022 we enrolled 1540 consecutive patients that was affected by COVID. Every patients was admitted to ambulatory of sport medicine of 2 Italian centers to perform a return to play agonistic certificate. All patients perfomed an echocardiogram during the evaluation. We subdivided the incidence of carditis depend on the period and the variant of the covid (alpha, beta, gamma, delta, epsilon). Overall, 69% males and 31%. females were enrolled with a mean age of 24.3 years (12–67 years). None presented note risk factor of a cardiac disease.

Results
The incidence of Echocardiographic abnormality was 3,2% in all period. By the echocardiogram we recognize 8 dilated cardiomiopathy (0,4%), 8 regional kinetic dysfunction (0,4%), 30 pericardial effusion (1,9%), 4 non-specific alterations (0,2%). Also we evaluated the incidence of the echocardiographic disease during the quarters and in correlation of COVID Variant. The results was showed in figure 1.

Conclusions
Based on our evaluation the incidence of echocardiographic findings in COVID was 3,2%, with a progressive reduction long the time, from alpha to omicron variants.
The use of quality improvement interventions in reducing inappropriate cardiac imaging
Authors: Tao M , Al-Sadawi M , Ghosalkar D , Frye J , Despotidis G , Miller A 
Published: June 2023

Abstract

Funding Acknowledgements
Type of funding sources: None.

Background
The utilization of cardiac imaging has become increasingly prevalent worldwide over the last decade. Approximately 10–15% of non-invasive cardiac imaging is ordered for inappropriate indications. Professional societies have created appropriate use criteria (AUC) in order to decrease unnecessary testing and reduce healthcare costs. However, it remains unclear whether these efforts have been successful. This meta-analysis evaluates whether AUC-based quality improvement (QI) interventions are effective at reducing inappropriate cardiac imaging.

Methods
Databases were searched for studies reporting the effect of QI interventions aiming to reduce rarely appropriate noninvasive cardiac imaging based on AUC. Imaging modalities assessed include echocardiography, CT imaging, and nuclear imaging.
We searched Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL. The primary endpoint was a reduction of rarely appropriate testing. The search was not restricted to time or publication status.

Results
The literature search identified 2391 possible studies, 12 studies and 26,557 patients were included. Mean follow-up was 12 months (1–60 months). QI interventions utilized included education tools, decision support tools, and feedback tools. QI interventions were statistically significant in reducing rarely appropriate tests after the intervention compared to the control group (OR 0.51, 95% CI 0.41–0.64; p&lt;0.01). The QI interventions were also assessed for persistence based on short-term (&lt;3 months) and long-term (&gt;3 months) efficacy. Both the short term effect and long term effect were persistent (OR 0.6, 95% CI: 0.47–0.77; p&lt;0.01 and OR 0.47, 95% CI: 0.37–0.61; p&lt;0.01 respectively) (Figure 1).

Conclusion
AUC QI interventions are associated with the successful reduction of inappropriate non-invasive cardiac testing with these effects persisting over time.