bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief psychological intervention to reduce psychological distress among preoperative cancer patients: A randomized, single-blind, two arm, parallel group controlled trial in a selected tertiary care hospital in Sri Lanka
Authors: Alles Prasangika Seneviratne , Alagiyawanna Dushyanthi , Seneviwickrama Maheeka , Nanayakkara Sarangi , Kariyawasam Maneesh , Pathirana Aloka 
Published: May 2023

Abstract
Purpose
Psychological distress among pre-operative cancer patients interferes with treatment outcomes. A randomized, single-blind, two arm, parallel group controlled trial was conducted to determine the effectiveness of a 3-week brief psychological intervention versus routine care on reducing psychological distress among 18–65 year old newly diagnosed cancer patients awaiting surgery at Colombo South Teaching Hospital.
Methods
After screening 153 patients for eligibility, 88 were recruited (intervention = 46, control = 42). The primary outcome, psychological distress, was assessed using HADS (cut-off 8) at baseline and 3-weeks later. Secondary outcomes assessed were satisfaction on knowledge and care they received and the physical well-being. Comparisons were made using McNemar’s Chi-Square at p < 0.05 based on intention to treat. Effects measures used are odds ratios (OR) with 95% CI and number needed to treat (NNT).
Results
Prevalence of anxiety and depression at baseline was 90.91% and 89.77%. Intervention significantly lowered anxiety [intervention 30.43% vs control 69.50%, OR = 0.20 (95% CI 0.08, 0.49), p = 0.0004]. Depression failed to show a significant reduction [67.6% vs 78.4%, OR = 0.53 (95% CI 0.22, 1.28), p = 0.1592]. NNT to avert one case of anxiety is 3 (95% CI 1.73, 5.18). Satisfaction on care received is the only secondary outcome that showed a statistically significant association: intervention 36.96% vs. control 14.28% [OR = 0.28 (95% CI 0.10–0.81), p = 0.0057].
Conclusion
The brief psychological intervention was effective in reducing anxiety among newly diagnosed cancer patients. This simple and brief psychological intervention could be recommended for all new cancer patients awaiting surgical interventions.
This trial was registered in the Sri Lanka clinical trial registry on 14.10. 2021. The registration number is SLCTR/2021/028. The protocol is available at the Sri Lanka clinical trial registry website. The Universal Trial Number (UTN) is U1111-1269-2819.
Dachengqi Decoction alleviates acute pancreatitis by down-regulating autophagy related protein Beclin1
Authors: Li Jie , Li Hongchang , Huang Ye , Feng Dianxu , Chen Yafeng , Wu Xubo 
Published: May 2023

Abstract
Objective: Acute pancreatitis (AP) is a common acute abdominal disease characterized by pancreatic acinar cell death and inflammation. Excessive autophagy of acinar cells will aggravate AP, further develop into SAP, and even endanger life. Dachengqi Decoction (DCQD) is a commonly used drug in clinic for acute pancreatitis. Beclin1 is a vital autophagy-related molecule in disease. We investigated DCQD treat acute pancreatitis by intervening Beclin1 to regulate the autophagy of acinar cells.Methods: Wistar rats were injected intraperitoneally with 20% L-arginine to reproduce AP rat model. AP rat were treated with DCQD and 3-Methyladenine (3-MA) and compared to AP rats pre-treated with 20% L-arginine. we examined the levels of serum TNF-α, Beclin1 and Reactive Oxygen Species (ROS) by ELISA; stained the pancreas tissues of rats with Hematoxylin-eosin staining (HE); observed the autophagy formation in pancreas tissues by transmission electron microscopy; and detected the expression of Beclin1 and light chain 3-Ⅱ(LC3-II) protein level in pancreas tissues by Western blot and immunohistochemistry.Result: The levels of serum Amylase, Beclin1, ROS, TNF-α and pathological scores of pancreas were significantly elevated by injected intraperitoneally with 20% L-arginine. The results of electron microscopy showed that the autophagy of pancreatic tissue increased significantly in AP rats, but decreased in rats treated with DCQD or 3-MA. DCQD and 3-MA could significantly reduce the levels of serum Amylase, Beclin1, ROS and TNF-α in rats. Western blot and immunohistochemical results showed that DCQD and 3-MA significantly reduced Beclin1 and LC3-II proteins.Conclusion: Our studies showed that Beclin1 is closely related to acute pancreatitis, and DCQD could inhabited Beclin1 and excessive autophagy.
Opportunistic screening for familial hypercholesterolemia based on observational registries data analysis
Authors: Gaisenok O. V. 
Published: May 2023

Introduction. Early diagnosis of FH is generally low. This leads to the early formation of atherosclerotic cardiovascular diseases (ACVD) and increases the risk of cardiovascular complications in young and middle-aged people. Aim. Identification of HeFH patients using the Dutch Lipid Clinic Network Criteria based on the analysis of electronic databases of two observational registries. Materials and methods. 3,895 persons were selected from 10,606 participants in the Duplex and Laboratory registries based on the presence of TC and LDL-C indicators registered in the databases and the criterion of age up to 60 years. Dutch Lipid Clinic Network Criteria (DCLN) were used as criteria for HeFH: “definite” in the presence of >8 points, “probable” in the presence of 6–8 points, “possible” FH in the presence of 3–5 points. The “definite” and “probable” groups were combined into “potential” FH group. Results. LDL-C levels ≥5 mmol/l and ≥6.5 mmol/l were detected in 8.7% and 0.7% of study participants, respectively. Among them, only 2 patients with DLCN criterion >8 points were identified. Potential FH was found in 13 patients. When recalculated per 100,000, the average prevalence of potential FH was 334/100,000 people (0.33%). Conclusions. Opportunistic screening is an affordable and effective tool in the hands of clinicians to optimize the detection of FH patients. It is advisable to use DCLN criteria, which are optimal as FH criteria. A well-proven method for analyzing electronic databases based on the study of electronic medical records, the use of a “potential” FH model and automated integration of the obtained data can significantly facilitate the task. Studies on larger cohorts of patients are needed to improve the detection of FH among young people.
Carotenoids: dietary sources, adequate and clinically effective doses
Authors: Kodentsova V. M. , Risnik D. V. 
Published: May 2023

Natural food sources of carotenoids are colored vegetables and fruits, eggs, milk. Total carotenoid intake varies from 1 to 22 mg/day in European countries and from 5 to 16 mg/day in the USA. The average daily intake of lycopene in Europe ranges from 5 to 7 mg/day, in the USA – from 5.7 to 10.5 mg/day. Carotenoids are used in the production of fortified foods, biologically active food supplements, specialized foods for various population groups, as well as natural food colors added directly during the production of a food product or in feed for farm animals. Epidemiological studies have shown that dietary carotenoid intake is inversely associated with obesity, retinopathy, cataracts; cardiovascular disease (CVD), diabetes and some cancers. According to the domestic regulatory framework, the adequate level of daily intake of carotenoids is 15 mg, 5 mg of β-carotene, lycopene and lutein, the upper permissible level of consumption of carotenoids as part of dietary supplements and specialized food products is 30 mg (10 mg each). For zeaxanthin, these values are 1 and 3 mg/day. Daily doses of lycopene used in intervention studies were 15–90 mg, and β-carotene 15–50 mg. lutein – 4–20 mg; zeaxanthin – 1–20 mg; mezoxanthin 12 mg, astaxanthin – 12–16 mg. Duration of admission was 4–12 months (up to 48 months). Taking lycopene at a dose of 10–15 mg for several months led to a decrease in indicators of oxidative stress, markers of bone resorption, taking lutein at a dose of ≥ 10 mg improved visual and cognitive functions. The effective doses of carotenoids correspond to or exceed the permitted allowable level of their consumption as part of dietary supplements and specialized food products.
Experience with the prolonged release of iron in iron deficiency patients
Authors: Drozdov V. N. , Shikh E. V. , Astapovskii A. A. , Tsvetkov D. N. 
Published: May 2023

Iron deficiency is one of the leading factors in the global burden of disease, affecting mainly children, premenopausal women and low- and middle-income people. With prolonged iron deficiency, iron deficiency anemia (IDA) develops, which, according to the World Health Organization (WHO), remains the most common type of anemia worldwide. The most common causes of IDA include gastrointestinal bleeding, menstrual blood loss and pregnancy in women. Currently, divalent iron preparations are considered the “gold standard” of IDA therapy. To date, there are preparations of divalent iron with delayed release. The advantage of this form is that such drugs are better tolerated, they have a lower incidence of side effects with comparable bioavailability and efficacy compared to conventional forms. Such drugs include Tardyferon®.In our study, it was noted that against the background of taking Tardyferon®, the level of ferritin by the end of the 1st month of therapy in patients with latent iron deficiency increased from 12.4 ± 0.93 to 27.8 ± 4.1 µg/L (p ≤ 0.05). In patients with IDA, it increased from 9.7 ± 1.3 to 25.4 = 5.1 µg/L. By the end of the 3rd month of treatment, the ferritin level in patients with latent iron deficiency was 200.1 ± 30.8 (p < 0.05), and in patients with IDA – 246.7 µg/L (p < 0.05). We noted a similar dynamic in the hemoglobin level: in patients with IDA, it increased from 97.4 ± 9.3 g/L to 125.8 ± 10.2 g/l (p < 0.05), and in 21 (75%) of 28 patients it reached normal values (more than 120 g/L) by the end of the 1st months of therapy.By the 3rd month of therapy, all patients with IDA had already reached the target level, and the average hemoglobin value in the group was 142.1 ± 5.6 g/L (p = 0.05).Thus, in patients with IDA, against the background of therapy with Tardyferon®, hemogram indicators normalize, the concentration of hemoglobin and ferritin increases by the end of the 1st month of therapy.
Identification and Synthesis of Process-Related Impurities in Lisdexamfetamine
Dimesylate
Authors: Mandavkar Sagar , Gole Pradip , Pawar Rushikesh , Deshmukh Vishal , Kishore DVP , Bonde Nilesh L. , Kotharkar Sandeep A. , Joshi Sunil V. 
Published: May 2023

Abstract:
During the process optimization of Lisdexamfetamine dimesylate, two process impurities
were observed.

Methods:
These impurities remained a concern for commercialization and were isolated, on characterization,
were found to be H-Lys-ε-Lys-d-amphetamine and other being its regio- isomer H-Lys-α-Lysd-
amphetamine. The main target of this study was to synthesize reference compounds for HPLC analysis
of these impurities produced in Lisdexamfetamine.

Result:
To the best of our knowledge, these impurities are not commercially available and no synthetic
methods have been reported. Both of these potential impurities were synthesized, and their structures
were established by various spectral techniques.

Conclusion:
Furthermore, herein we also report the synthesis of two process impurities Boc-
Lys(Boc)-ε-Lys(α-Boc)-O-Nitrophenol and Boc-Lys(Boc)-α-Lys(ε-Boc)-O-Nitrophenol and their fate
for the formation of impurities H-Lys-ε-Lys-d-amphetamine and H-Lys-α-Lys-d-amphetamine.
Variant regression modeling of electricity production in the Russian Federation
Authors: Noskov S. I. , Popov E. S. , Seredkin S. P. , Tirskikh V. V. , Toropov V. D. 
Published: May 2023

Objective. The aim of the study is to build a linear regression model of electricity generation in the Russian Federation depending on resource indicators, which include: the volume of coal and gas production, the production of fuel oil. Statistical data for 2005 - 2020 were used as the information base of the study.Method.Estimation of unknown parameters of the linear model is carried out using three methods - least squares, modules and anti-robust estimation. They behave differently with respect to outliers in the data. The second of them does not react to outliers at all, completely ignoring them, and the third, on the contrary, strongly gravitates towards them, therefore, these methods are a kind of antagonists in relation to each other.Result.Three alternative models of a linear regression model of electricity production with high accuracy are obtained. The value of the parametric stability index of the data sample, based on the properties of the parameter estimation methods, is calculated. Observations are identified that correspond to the maximum and minimum extent to the linear model on the analyzed sample. The values of the contributions of the factors to the right parts of the models are calculated.Conclusion.Three versions of the model built by different methods can be successfully used to solve problems related to forecasting the production of electricity in the country. At the same time, the variant constructed by the least squares method is a kind of compromise.
Algorithm for monitoring the dynamic zone of forest fires by a group of unmanned aircraft
Authors: Tebueva F. B. , Antonov V. O. , Kabinyakov M. Yu. , Svistunov N. Yu. 
Published: May 2023

Objective. The aim of the study is to develop an algorithm for monitoring forest fire zones, carried out by unmanned aerial vehicles (UAVs).Method. The study is based on methods of algorithmic support, methods of analysis and synthesis of automated control systems for technological objects.Result. The technologies and methods for monitoring forest fires are considered, which confirms the relevance of the use of UAVs to perform these tasks. An algorithm for the use of UAV swarms for monitoring forest fire zones is presented. The algorithm includes enlarged stages of decomposition of the global problem, distribution of tasks, application of methods of collective decision-making, etc.Conclusion. The proposed algorithm can be implemented subject to the development of swarm control theory.
Bourdieu dan Perspektif Alternatif Kajian Jurnalistik
Authors: Krisdinanto Nanang 
Published: May 2023

Naskah ini merupakan literature review yangmengelaborasi pikiran Pierre Bourdieu tentang jurnalismeyang dapat digunakan sebagai perspektif alternatif dalammemahami dinamika praktik jurnalistik. Ada dua hal yangmembuat pikiran Bourdieu menarik dan penting untuk dikajidalam konteks jurnalistik. Pertama, perspektif Bourdieumasih jarang digunakan untuk memahami, mengutai,atau menginvestigasi dinamika yang terjadi dalam praktikjurnalistik. Padahal, konsep-konsep kunci seperti arena,habitus, dan modal dapat digunakan untuk menyingkapberbagai dinamika yang terjadi di dalam praktik jurnalistik.Kedua, orientasi teoritik Bourdieu mampu membukaruang untuk memahami praktik jurnalistik tanpa harusterjebak ke dalam dikotomi perspektif yang kaku di antaraperspektif ekonomi politik/organisasional/budaya danperspektif cultural studies. Konsep kunci Bourdieu dapatdigunakan untuk mengungkap kompleksitas praktikjurnalistik yang diabaikan masing-masing perspektif. Konsep kunci Bourdieu juga dapat membuat penelititerhindar dari bahaya mereduksi praktik jurnalistik menjadihanya sekadar proses makro (seperti politik, ekonomi,atau budaya yang berbasis struktur sosial objektif), atausebaliknya hanya sebatas proses mikro (yang berbasiskebebasan atau kreativitas subjek). Dengan kata lain,konsep kunci Bourdieu digunakan sebagai alat analisisyang mampu mengkoneksikan dinamika praktik jurnalistikdengan struktur politik, ekonomi, sosial, atau budaya yangmelingkupinya.
In vitro evaluation of coenzyme Q10 on primary fibroblast culture
Authors: Herawati Dahlia 
Published: May 2023

Chronic inflammation in periodontitis results in continuous production of Reactive Oxygen Species (ROS), so the levels are excessive, causing destruction of the gingiva, periodontal ligament, and alveolar bone through a variety of mechanisms including DNA damage and the formation of proinflammatory cytokine. One way to prevent periodontal tissue damage caused by excessive ROS formation is by administering antioxidants. Coenzyme Q10 is a powerful antioxidant that is beneficial for inhibiting free radicals to prevent the progression of periodontal tissue destruction and accelerate healing processes. The purpose of this study was to evaluate the fibroblast proliferation of the combination of Coenzyme Q10 and vegetable glycerin compared to PerioQ. Materials used were made of original Coenzyme Q10 dissolved in glycerin that was prepared in a ratio of 2:8 and 1:9, and Perio Q as the control. Each group consisted of six samples (n = 6). Primary fibroblasts were derived from healthy gingival tissue. Observations on day-1, -3, and -5 using MTT assay at a wavelength of 550nm. Statistical analysis used a Two-Way ANOVA test followed by a Post Hoc test. The experiment showed the absorbance values were high in all the groups, the highest value was on day 3, namely Coenzyme Q10 at a concentration of 2:8, followed by Coenzyme Q10 at a concentration of 1:9, and PerioQ. The statistical tests showed significant differences in the 3 groups (p < 0.05). It is concluded that Coenzyme Q10 in 1:9 and 2:8 concentrations were both as viable as Perio Q towards primary gingival fibroblast culture.
IDENTIFICATION OF TEUNGKU CHIK MUHAMMAD AMIN'S LEGACY
Authors: Dewi Yanti , Marduati  
Published: May 2023

Teungku Chik Muhammad Amin is a scholar from Aceh who is descended from South Yemen's Arab community. Along with promoting society's understanding of Islam and the fight against Dutch forces, he is a person who is quite tenacious. This study's objectives were to learn more about Teungku Chik Muhammad Amin's life, identify his remains, and assess their state of preservation. The explicative (explanatory) or descriptive methods used in this study give a general overview of the archaeological data discovered in terms of time, form, and space as well as demonstrating the correlation between various research variables. In Meunasah Mancang Village, Tiro Truseb District, Pidie Regency, data were gathered by direct observation, interviews, literature reviews, and documentation. Aspects of the data's morphology, technology, and stylistic composition were characterized and examined. The identification has revealed various Teungku Chik Muhammad Amin relics, including Zawiyah Cut, a study hall, an old pond or ablution site, and an old well. Teungku Chik Muhammad Amin's remains have similarly gotten less attention from the parties involved, as seen by their current state. The government of Pidie Regency and other relevant parties are urged to be able to preserve this historical legacy as the cultural heritage of the Acehnese people.
IMPLEMENTASI CSR PT SURYA PANEN SUBUR (SPS) II DI NAGAN RAYA DALAM PERSPEKTIF AKAD TABARRU’
Authors: Rosita Ari , Sholihin Riadhus 
Published: May 2023

Corporate Social Responsibility (CSR) merupakan salah satu program yang dipandang sebagai tanggung jawab sosial perusahaan untuk kesejahteraan masyarakat. Tanggung jawab sosial perusahaan tersebut disalurkan dalam bentuk program Pendidikan, Lingkungan, Agama dan Sosial. Namun secara teori daerah sekitaran perusahaan belum dapat mensejahterakan masyarakat secara luas, terlihat dari data angka kemiskinan pada desa Puloe Kruet yang belum berubah dari tahun ketahun sesuai dengan tujuan CSR. Masalah yang diteliti pada skripsi ini ada 3 macam yaitu, pertama untuk mengetahui implementasi CSR pada PT SPS II, kedua untuk mengetahui faktor yang mempengaruhi implementasi CSR, ketiga untuk mengetahui tinjauan akad tabarru’ terhadap implementasi CSR pada PT SPS II di Nagan Raya. Jenis metode penelitian yang digunakan adalah penelitian lapangan dan pustaka dengan teknik pengumpulan data yaitu, wawancara, observasi dan studi dokumentasi dengan analisis deskriptif. Hasil penelitian menunjukkan bahwa, pertama perusahaan memberikan bantuan kepada masyarakat dalam bentuk program CSR yang telah disepakati, kedua faktor yang mempengaruhi implementasi CSR ada dua yaitu: faktor Internal yang di dukung oleh perusahaan karena perusahaan memiliki wewenang penuh dalam mengelola dana CSR dan faktor Eksternal yang di dukung oleh masyarakat terhadap program CSR pada PT SPS II, ketiga program CSR pada PT SPS II telah menerapkan berdasarkan prinsip dasar akad tabarru’sesuai dengan rukun dan syarat. Saran dari penelitian ini diharapkan perusahaan dalam manyalurkan bantuan agar lebih terbuka dan dapat mengawasi bantuan yang telah di berikan sehingga program CSR agar dapat mensejahterakan masyarakat
AKTUALISASI PERAN PEMERINTAH DALAM MENJAGA STABILITAS HARGA MELALUI MEKANISME TAS’ĪR
Authors: Noufal azmi  
Published: May 2023

The market mechanism in the Islamic muamalah system is based on the free market (free market, sūq al-ḥurrah). Moeslem Scholars agreed that the law of origin of pricing (tas'īr) was forbidden and should not be done. However, the fukaha are not cohesive in establishing the legal position of tas'īr when there is a tyranny or monopoly of iḥtikār goods. This study is a library research, with a conceptual approach. The study aims to find out the opinion of Wahbah al-Zuḥailī regarding the actualization of the role of the government in maintaining price stability through tas'īr, and also to know its relevance to the current context. The results showed that Wahbah Al-Zuḥailī recognized the ability of tas'īr when there was a need (al-ḥājah). The actualization of the role of the government in maintaining stability and normalization of prices can be carried out in the event of one of two indicators, namely the practice of iḥtikār and traders selling goods at a profit greater than 30% of the original price. The government is authorized and justified in imposing ta'zr administrative sanctions, such as imprisonment, fines, and shop closing sanctions (revocation of business licenses). Al-Zuḥailī's view is relevant to the current context, because in developing countries, especially in Indonesia, the government also has the authority to conduct market supervision, market intervention, and issue price policies when there is a shortage and prices of basic necessities are high. In Indonesia, the government's authority to maintain price stability is regulated in Law Number 7 of 2014.

Keywords: Actualization, Government role, Price Stability, Tas'īr
STRATEGI PENGEMBANGAN PRODUK PEMBIAYAAN MUSYARAKAH PT. BANK ACEH KEPADA PELAKU USAHA UMKM KOTA BANDA ACEH DI MASA PANDEMI
Authors: Nafisah Nada , Ashal Farid Fathony , Aulia Riza 
Published: May 2023

This study aims to determine the contribution of gampong funds in the development of BUMG Amarabu, Simeulue Cut District, Simeulue Regency and the role of BUMG in the economic development of the community in Amarabu. This study uses a qualitative approach with a descriptive type of research. Informants consisted of geuchik, village officials, community leaders, BUMG administrators and the community. Data collection techniques are interviews, observation, documentation and literature study. Based on the results of the study, it is known that the contribution of gampong funds in the development of BUMG, Simeulue Cut District, Simeulue Regency includes increasing the income of the BUMG itself through community economic efforts so that Gampong-Owned Enterprises are always active in carrying out their activities in Gampong Amarabu. The role of Gampong-Owned Enterprises in the economic development of the community in Amarabu, Simeulue Cut District, Simeulue Regency includes supporting the strengthening of community business activities in collaborating with various parties who have potential in the field of improving the Amarabu community's business. Accommodating and fostering the community in business activities so that it becomes a source of income that is able to foster motivation and innovation in the business world. Increase community economic resilience through business activities that can create jobs.
Keywords: Development Strategy, Musyarakah Financing Products, Bank Aceh, MSME