bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Really Works? Testing Augmented and Virtual Reality Messaging in Terrestrial Invasive Species Management Communications to Impact Visitor Preferences and Deter Visitor Displacement
Authors: Schneider Ingrid , Rannow Brett , Gupta Angela , Russell Matt , Windmuller-Campione Marcella 
Published: January 2023

AbstractNatural resource management is rapidly shifting to incorporate a deeper understanding of ecological processes and functioning, including attention to invasive species. The shift to understand public perceptions of resource management and invasives is much slower. Information influences both landscape preference and behaviors. Theory suggests that increasingly engaging information should have concurrently greater impacts. This research tested the effect of increasingly engaging information on visitor preferences and intentions to return to landscapes treated in response to emerald ash borer (EAB; Agrilus planipennis). Park visitors in a midwestern-U.S. state randomly received one of four messages about forest management in response to EAB (control, photo, augmented reality (AR) and virtual reality (VR)). Messaging impacted preferences for three of the four management approaches, but significant changes in displacement intentions emerged in only one of the four. Specifically, VR and AR increased preferences for complete harvest compared to photos/text, but not differently from those who received no information. VR significantly lowered preferences for select harvest with natural regeneration. The photo/text treatment increased preference for select harvest with planted trees over no information. Any information reduced displacement in response to a photo depicting “select harvest, planted trees.” Subsequently judicious use of advanced communications like VR can optimize increasing scarce resources and maintain or optimize ecological services. Future research directions across geographic and content areas are recommended.
Revisiting informed consent in forensic genomics in light of current technologies and the times
Authors: Budowle Bruce , Sajantila Antti 
Published: January 2023

AbstractInformed consent is based on basic ethical principles that should be considered when conducting biomedical and behavioral research involving human subjects. These principles—respect, beneficence, and justice—form the foundations of informed consent which in itself is grounded on three fundamental elements: information, comprehension, and voluntary participation. While informed consent has focused on human subjects and research, the practice has been adopted willingly in the forensic science arena primarily to acquire reference samples from family members to assist in identifying missing persons. With advances in molecular biology technologies, data mining, and access to metadata, it is important to assess whether the past informed consent process and in particular associated risks are concomitant with these increased capabilities. Given the state-of-the-art, areas in which informed consent may need to be modified and augmented are as follows: reference samples from family members in missing persons or unidentified human remains cases; targeted analysis of an individual(s) during forensic genetic genealogy cases to reduce an investigative burden; donors who provide their samples for validation studies (to include population studies and entry into databases that would be applied to forensic statistical calculations) to support implementation of procedures and operations of the forensic laboratory; family members that may contribute samples or obtain genetic information from a molecular autopsy; and use of medical and other acquired samples that could be informative for identification purposes. The informed consent process should cover (1) purpose for collection of samples; (2) process to analyze the samples (to include type of data); (3) benefits (to donor, target, family, community, etc. as applicable); (4) risks (to donor, target, family, community, etc. as applicable); (5) access to data/reports by the donor; (6) sample disposition; (7) removal of data process (i.e., expungement); (8) process to ask questions/assessment of comprehension; (9) follow-up processes; and (10) voluntary, signed, and dated consent. Issues surrounding these topics are discussed with an emphasis on addressing risk factors. Addressing informed consent will allow human subjects to make decisions voluntarily and with autonomy as well as secure the use of samples for intended use.
Steroidal glycoside profile differences among primary roots system and adventitious roots in Solanum dulcamara
Authors: Chiocchio Ilaria , Andrés Nerea Pérez , Anaia Redouan Adam , van Dam Nicole M. , Vergara Fredd 
Published: January 2023

Abstract
Main conclusion
Solanum dulcamara primary and adventitious roots showed qualitative and quantitative differences in their steroidal glycosides profile. This opened new venues to evaluate the bioactivity of these molecules in belowground ecosystems.

Abstract
The Solanum genus is characterized by the presence of steroidal glycosides (SGs) that confer herbivore resistance and serve as drug precursors in the pharmaceutical industry. Solanum dulcamara is a self-compatible, sexually reproducing species that produces seeds after buzz-pollination. In addition, primordia on the stem facilitate clonal propagation via adventitious root (AR) formation. ARs contain aerenchyma being developmentally and morphologically different from primary roots (PRs). Therefore, we hypothesized that ARs and PRs have different SG profiles. Aiming to assess differences in SGs profiles in S. dulcamara roots in relation to their origins and morphologies, we used liquid chromatography coupled to electron spray ionization quadruple time of flight mass spectrometry (LC-ESI-qToF-MS) to profile SGs from PRs and ARs of seven S. dulcamara individuals. Mass fragmentation pattern analysis indicated the presence of 31 SG-type structures, including those with spirostans and furostans moieties. We assigned the 31 structures to 9 classes of steroidal aglycons (SAgls) that differ in hydroxylation and degree of unsaturation. We found that SAgls were conjugated with di-, tri- and tetra saccharides whereby one compound contained a malonylated sugar. Principle component analysis showed that SG profiles of PRs and ARs separated on the first principal component, supporting our hypothesis. Specifically, PRs contain higher number of SGs than ARs with some compounds exclusively present in PRs. Our results reveal a high level of novel chemodiversity in PRs and ARs of Solanum dulcamara. The knowledge gained will deepen our understanding of SGs biosynthesis and their functional role in plant-environment interactions.
The Dump is the Target—A Reversed Mine Plan
Authors: Haindl Angelika 
Published: January 2023

AbstractMine plans usually need to consider the tonnage that must be stored in the dumping area and the machine hours required to place material there as a constraint. The Department of Mining Engineering and Mineral Economics was involved in a project, in which the whole mine planning procedure had to start with the dump. To start with a dump, formulating the targets for the mine plan did require some adaptation of the standard mine planning procedure. After a proper set-up, the schedule was updated several times to optimize it. In total, six complete scenarios have been created where the dam could be built in the simulation.For confidentiality reasons no details on the project location or project coordinator are included in the text.
Single-phase grid interface for home energy storage
Authors: Bosnjic Zlatko , Krischan Klaus 
Published: January 2023

AbstractIn this paper, an overview of a novel home energy storage system is presented. The aim of the system is the utilization of community solar panels in urban environments with decentralized energy storage at the household level. An increase in the total energy production from renewable energy sources as well as a reduction in energy costs for the consumer are the obvious benefits of such a system. The key focus of the paper presented is to model, design, and optimize a Dual Active Bridge that serves as a low-voltage grid-battery interface for the proposed storage system. A state-of-the-art loss model of the Dual Active Bridge is presented along with a novel optimization method intended for total power loss minimization.
Effect of depression, anxiety, and distress screeners on the need, intention, and utilization of psychosocial support services among cancer patients
Authors: Springer Franziska , Sautier Leon , Schilling Georgia , Koch-Gromus Uwe , Bokemeyer Carsten , Friedrich Michael , Mehnert-Theuerkauf Anja , Esser Peter 
Published: January 2023

Abstract
Purpose
In clinical cancer care, distress screening is recommended to identify highly burdened patients in objective need for psychosocial support to improve psychological distress and quality of life and to enhance patient empowerment. It is however unclear whether distress screeners are suitable for psychosocial care planning and thus whether they can predict the willingness that is need, intention, and utilization, to seek psychosocial support.

Methods
In a secondary analysis of a cluster intervention study, we assessed cancer patients with three distress screeners (DT, PHQ-9, GAD-7) at baseline. The willingness to seek psychosocial support services was assessed binary for psychosocial services at 3 and 6 months. Logistic regression models were applied to examine the predictive effect of the screeners on need, intention, and utilization. We corrected all models for multiple testing.

Results
The 660 patients included in the study were on average 60 years, 54% were male. At the 3- and 6-month follow-up, 353 and 259 patients participated, respectively. The screeners were best in predicting the need for support (OR reaching up to 1.15, 1.20, and 1.22 for the PHQ-9, GAD-7, and DT respectively). The intention was predicted by the PHQ-9 and GAD-7, whereas utilization of psychosocial support services was not predicted by the screeners.

Conclusion
The three distress screeners might be useful in psychosocial care planning, as they are able to predict the need and to some degree the intention to seek psychosocial support. Future research needs to examine potential barriers and supporting factors that may explain utilization of psychosocial support.

Trial registration
The study was retrospectively registered (2/2021) at ClinicalTrials.gov (number: NCT04749056).
Effect of TNF inhibitors on arterial stiffness and intima media thickness in rheumatoid arthritis: a systematic review and meta-analysis
Authors: Abdulmajid Bafrin , Blanken Annelies B. , van Geel Eva H. , Daams Joost G. , Nurmohamed Michael T. 
Published: January 2023

AbstractControlling inflammation with tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients is hypothesized to reduce their cardiovascular risk. We performed a systematic review and meta-analysis on the effects of TNF inhibitors on arterial stiffness and carotid intima media thickness (IMT) in RA. MEDLINE, EMBASE, clinicaltrials.gov, and WHO Clinical Trials Registry were searched up to September 2021 for randomized controlled trials, prospective cohort studies, and nonrandomized clinical trials evaluating the effects of TNF inhibitors on pulse wave velocity (PWV), augmentation index (AIx), and IMT in RA. A meta-analysis was performed to assess changes of these measures after therapy during different follow-up periods. Risk of bias assessment was performed using an adjusted Downs and Black checklist (INPLASY: 2022-1-0131). Thirty studies were identified from 1436 records, of which 23 were included in the meta-analysis. PWV and AIx showed a decrease after treatment (PWV: mean difference (MD) −0.51 m/s (95% CI: −0.96, −0.06), p=0.027; AIx: MD −0.57% (95% CI: −2.11, 0.96), p=0.463, sensitivity analysis AIx: MD −1.21% (95% CI: −2.60, 0.19), p=0.089). For IMT, there was a slight increase in the first months of follow-up, but this disappeared on the long-term (overall timepoints MD −0.01 mm (95% CI: −0.04, 0.02), p=0.615). Heterogeneity was high in the overall analyses and subgroups with long follow-up periods (≥12 months). The included studies showed mixed results of the effects of TNF inhibitors on the surrogate markers. The pooled results suggest that PWV and AIx decrease over time, while IMT remains stable. This indicates a favorable effect of TNF inhibitors on the cardiovascular disease risk, all the more since these markers also increase with age.
Cyber insurance: state of the art, trends and future directions
Authors: Tsohou Aggeliki , Diamantopoulou Vasiliki , Gritzalis Stefanos , Lambrinoudakis Costas 
Published: January 2023

AbstractSociety has become increasingly dependent on IT infrastructure and services. Additionally, the pandemic of COVID-19 forced the transition of the traditional way of working (i.e., physical presence) into a more modern and flexible one (i.e., working remotely). This has led to an increase of cyberattacks, as a direct consequence of the increase of the attack surface but subsequently also led to an increased necessity for the protection of information systems. Toward the protection of information systems, cyber insurance is considered as a strategy for risk management, where necessary. Cyber insurance is emerging as an important tool to protect organizations against cyberattack-related losses. In this work, we extensively examine the relevant literature on cybersecurity insurance, research and practice, in order to draft the current landscape and present the trends.
DNA methylation-based subtypes of acute myeloid leukemia with distinct prognosis and clinical features
Authors: Jian Jimo , Yuan Chenglu , Ji Chunyan , Hao Hongyuan , Lu Fei 
Published: January 2023

AbstractAcute myeloid leukemia (AML) is a malignancy of the stem cell precursors of the myeloid lineage. DNA methylation is an important DNA modification that regulates gene expression. Investigating AML heterogeneity based on DNA methylation could be clinically informative for improving clinical diagnosis and prognosis. The AML subtypes based on DNA methylation were identified by unsupervised consensus clustering. The association of these subtypes with gene mutation, copy number variations, immune infiltration and clinical features were further explored. Finally, univariate, LASSO and multivariate cox regression analyses were used to identify prognosis-associated genes and construct risk model for AML patients. In addition, we validated this model by using other datasets and explored the involved biological functions and pathways of its related genes. Three CpG island methylator phenotypes (CIMP-H, CIMP-M and CIMP-L) were identified using the 91 differential CpG sites. Overall survival, morphology, macrophages M0 and monocytes were distinct from each other. The most frequently mutated gene in CIMP-L was DNMT3A while which in CIMP-M that was RUNX1. In addition, the TIDE scores, used to predict the response to immune checkpoint inhibitors, were significantly different among CIMPs. The CIMP-associated prognosis risk model (CPM) using 32 key genes had convinced accuracy of prediction to forecast 0.5-year, 1-year, 3-year and 5-year survival rates. Moreover, the risk score-related genes were significantly enriched in pattern specification process, regionalization, embryonic organ morphogenesis and other critical cancer-related biological functions. We systematically and comprehensively analyzed the DNA methylation in AML. The risk model we constructed is an independent predictor of overall survival in AML and could be used as prognostic factor for AML treatment.
Sales of Electronic Nicotine Delivery Systems (ENDS) and Cigarette Sales in the USA: A Trend Break Analysis
Authors: Selya A. , Wissmann R. , Shiffman S. , Chandra S. , Sembower M. , Joselow J. , Kim S. 
Published: January 2023

AbstractElectronic nicotine delivery systems (ENDS) are a potentially lower-risk tobacco product which could help smokers switch completely away from cigarettes. However, the lack of strong evidence to date of a measurable, population-level effect on reducing smoking has generated skepticism about ENDS’ potential benefits. This study examines whether increased US ENDS sales have been associated with reduced cigarette sales. Retail data on weekly per-capita cigarette and ENDS purchases in the USA during 2014–2019 were obtained from a national sample of brick-and-mortar retail outlets. Trends in cigarette sales were modeled before (2014–2016) ENDS had a substantial market share, and, after adjusting for macroeconomic factors, projected into the post-period (2017–2019). Actual cigarette sales were lower than projected sales (by up to 16% across the post-period), indicating a substantial “cigarette shortfall” in the post-period. To explore whether general (i.e., inclusive of potentially many mechanisms) substitution by ENDS can explain the cigarette shortfall, its association with per-capita ENDS volume sales was examined. Higher ENDS sales were significantly associated with a greater cigarette shortfall: for every additional per-capita ENDS unit, cigarette sales were 1.4 packs-per-capita lower than expected (B = 1.4, p < .0001). Error correction models which account for spurious correlation yielded similar results. These findings support ENDS serving as a substitute for cigarettes (through potentially many mechanisms including cigarette price), causing cigarette consumption to decline. Since ENDS potentially pose lower risk than cigarettes, this general substitution effect suggests that risk-proportionate tobacco regulation could mitigate the tobacco-related health burden.
Spatial distribution and pollution evaluation in dry riverbeds affected by mine tailings
Authors: Cuevas J. G. , Faz A. , Martínez-Martínez S. , Gabarrón M. , Beltrá J. C. , Martínez J. , Acosta J. A. 
Published: January 2023

AbstractThe objective of this study was to evaluate the level of pollution, sources and potential risk of heavy metals (Zn, Cu, Mn, Cd, Cr, Ni, Fe and Pb) and arsenic (As) in four dry riverbeds affected by mine tailing, which drain into one of the biggest coastal lagoon of Europe (Mar Menor). El Beal, La Carrasquilla, Las Matildes and Ponce dry riverbeds sediments were sampled along its course (20, 18, 13, 19 samples were collected, respectively), and total/soluble metal(loid)s, water soluble ions, nitrogen, and organic/inorganic carbon contents were analyzed. Spatial distribution, principal component analysis (PCA), hierarchical cluster analysis (HCA), contamination factor (Cf), pollution load index (PLI) and potential ecological risk index (RI) were used to identify the possible sources of metal(loid)s and to assess the sediment pollution status. The results showed that the mean total concentrations of As, Cu, Cd, Mn, Zn and Pb exceeded the natural background levels of the study area, with the highest values located close to the mining areas. Correlation and cluster analysis identified that Cd and Zn were associated mainly with anthropogenic activities for all riverbeds, while Cr and Ni come from parent. PLI graded the four riverbeds as contaminated by heavy metals, while RI manifested that 100% of samples located in El Beal, La Carrasquilla and Las Matildes had a significantly high ecological risk. Therefore, this study suggests that mine wastes are the main source of metal(loids) contamination in the dry riverbeds, which results can be used to design actions and measures to reduce the environmental impact of metal(loid)s in the Mar Menor coastal lagoon.
Trajectories of Change in Acute Dynamic Risk Ratings and Associated Risk for Recidivism in Paroled New Zealanders: A Joint Latent Class Modelling Approach
Authors: Stone Ariel G. , Lloyd Caleb D. , Spivak Benjamin L. , Papalia Nina L. , Serin Ralph C. 
Published: January 2023

Abstract
Objectives
Prior studies indicate risk for recidivism declines with time spent in the community post-incarceration. The current study tested whether declines in risk scores occurred uniformly for all individuals in a community corrections sample or whether distinct groups could be identified on the basis of similar trajectories of change in acute risk and time to recidivism. We additionally tested whether accounting for group heterogeneity improved prospective prediction of recidivism.

Methods
This study used longitudinal, multiple-reassessment data gathered from 3,421 individuals supervised on parole in New Zealand (N = 92,104 assessments of theoretically dynamic risk factors conducted by community corrections supervision officers). We applied joint latent class modelling (JLCM) to model group trajectories of change in acute risk following re-entry while accounting for data missing due to recidivism (i.e., missing not at random). We compared accuracy of dynamic predictions based on the selected joint latent class model to an equivalent joint model with no latent class structure.

Results
We identified four trajectory groups of acute dynamic risk. Groups were consistently estimated across a split sample. Trajectories differed in direction and degree of change but using the latent class structure did not improve discrimination when predicting recidivism.

Conclusions
There may be significant heterogeneity in how individuals’ assessed level of acute risk changes following re-entry, but determining risk for recidivism should not be based on probable group membership. JLCM revealed heterogeneity in early re-entry unlikely to be observed using traditional analytic approaches.
Spectrum splitting through CuS–ZnO/water hybrid nanofluid for agricultural greenhouse cooling applications: An experimental study
Authors: Sajid Muhammad Usman , Saghir M. Ziad , Dincer Ibrahim , Bicer Yusuf 
Published: January 2023

AbstractIn the present work, CuS–ZnO/water hybrid nanofluids (in concentrations of 0.0025 mass% and 0.005 mass%) are synthesized using a two-step method with nanoparticles composition of 95% CuS and 5% ZnO. The optically tuned nanofluid filter on the agricultural greenhouse roof can reduce the cooling load by transmitting the visible spectrum and absorbing the near-infrared radiation in the solar spectrum. The size distribution of nanoparticles, stability and optical transmission of both concentrations in the visible and near-infrared regions are examined. Two hollow containers (i.e., ducts) with thicknesses of 4 mm and 8 mm are prepared. Each of these ducts is attached to a greenhouse unit and placed in front of a solar simulator. The experimental results reveal that applying CuS–ZnO nanofluid reduces the inside temperature of the greenhouse unit under all irradiance and ambient temperature ranges. The cooling system gains an average of 27.4% less heat from the greenhouse unit when the CuS–ZnO nanofluid flows through an 8 mm duct compared to no-fluid case (empty duct). The photothermal conversion efficiency of nanofluid is found to be higher than the one for water. The crop growth factor of 82.2% is obtained for 8 mm duct case, and the photosynthetic photon flux density inside the greenhouse unit is reduced without affecting the growth of many plants. Furthermore, the payback period of the nanofluid system (with 8 mm duct) is calculated as 0.42 years, and the application of optically tuned nanofluid can help reduce the cooling system's size and energy requirement for cooling.