bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal fluid turnover as a driver of brain clearance
Authors: Smets Nina G. , Strijkers Gustav J. , Vinje Vegard , Bakker Erik N. T. P. 
Published: September 2023

AbstractCerebrospinal fluid (CSF) has historically been considered to function as a sink for brain‐derived waste disposal. Recent work suggested that CSF interacts even more intensely with brain tissue than previously recognized, through perivascular spaces that penetrate the brain. Cardiac pulsations, vasomotion, and respiration have been suggested to drive CSF flow in these perivascular spaces, thereby enhancing waste clearance. However, the intrinsic role of CSF production in relation to its distribution volume (turnover) is not an explicit component of recent concepts on brain clearance. Here, we review the work on CSF turnover and volume, focusing on preclinical evidence. Herein, we highlight the use of MRI in establishing CSF‐related parameters. We describe the impact of sleep, effect of anesthesia, aging, and hypertension on CSF turnover, and how this relates to brain clearance. Evaluation of the available evidence suggests that CSF turnover is a major determinant in brain clearance. In addition, we propose that several putative drivers of brain clearance, but also conditions associated with impaired clearance, such as aging, may actually relate to altered CSF turnover.
Are schools doing enough? An exploration of how primary schools in England support the well‐being of their teachers
Authors: Cotson William , Kim Lisa E. 
Published: September 2023

AbstractThough teacher well‐being (TWB) has been decreasing over time, there is an identified lack of awareness in schools across England on how settings can support TWB. To address this gap, this study provides teachers with a space to share their conceptualizations of well‐being, evaluate current school‐level TWB provisions, and provide recommendations for ways that existing TWB support could be enhanced. Semi‐structured interviews and focus groups were conducted with 16 primary school teachers across England. Reflexive thematic analytic findings indicated that participants defined well‐being in relation to their unique contexts, and cited some current school practices, including school and academy‐wide support and social support, as being effective for TWB. However, participants emphasized that they perceived current TWB provisions as tokenistic, which was suggested to be accentuated by poor understandings of TWB and pressures from the Office for Standards in Education (Ofsted) and COVID‐19. To address these issues, participants outlined the need for improvements in communication, the attitudes and approaches of Senior Leadership Teams toward TWB, increased provisions to both manage and decrease workload and increasing the amount of time that they have to meet expectations. Implications for policy and practice to enhance TWB are discussed.
Sociopsychological determinants of COVID‐19 vaccine acceptance and hesitancy among the students' of higher secondary schools in rural Bangladesh: A cross‐sectional study
Authors: Roy Debendra Nath , Islam Ekramul , Hossen Md. Mohabbot , Ferdiousi Nowrin , Azam Md. Shah 
Published: September 2023

AbstractAdministering coronavirus disease (COVID‐19) vaccines among the student of higher secondary schools has unprecedented importance for securing community health and ensuring in‐person class attainment. This study investigated higher secondary students' COVID‐19 vaccine acceptance and identified the underlying sociopsychological determinants of vaccine acceptance and hesitance. An anonymous, multi‐item, and closed‐ended questionnaire was developed from a theoretical analysis of relevant literature. Data were collected from April 2022 to August 2022 using a face‐to‐face interview approach. Binary logistic regression was employed to assess the study objectives. A total of 1514 students participated and the pooled COVID‐19 vaccine acceptance rate was 69.9% (95% confidence interval [CI] = 67.9─71.9). Out of 13 key determinants, “safety,” “efficacy,” and “communication” had highly significant positive associations (adjusted odds ratio [AOR], 95% CI = 3.542, 2.305–6.090; 2.494, 1.513–4.347; and 1.047, 1.008–1.912 respectively, p < .01), while “culture” had a significant positive association (AOR, 95% CI = 1.421, 1.002–1.502, p < .05) with vaccine acceptance. The binary logistic model also revealed that “side effects” and “injection anxiety” had significant negative associations (AOR, 95% CI = 1.483, 0.920–2.449; and 1.312, 0.911–1.625 respectively, p < .05) with the COVID‐19 vaccine acceptance. The odds of receiving the vaccine were found to be 1.9 and it was highly significant (p < .01) in the χ2 test. Psychological response to COVID‐19 vaccine from higher secondary students was found slightly lower. Side effects and injection anxiety were the psychological barriers associated with school‐going students' vaccination decision.
The effects of propolis supplementation on high‐sensitivity C‐reactive protein, testosterone hormone, and metabolic profile in women with polycystic ovary syndrome: A randomized, triple‐blinded, placebo‐controlled clinical trial
Authors: Abbasi Elahe , Bagherniya Mohammad , Soleimani Davood , Ghasemi‐Tehrani Hatav , Abbaspour Mohammadreza , Clark Cain C. T. , Askari Gholamreza 
Published: September 2023

AbstractOne of the most prevalent ovulation disorders is polycystic ovarian syndrome (PCOS). According to the anti‐inflammatory and beneficial effects of propolis, this triple‐blind controlled trial was designed to evaluate the effect of propolis on metabolic factors, high‐sensitivity C‐reactive protein, and testosterone in women with PCOS. Recruited patients from the gynecologist clinic were randomized based on a stratified permuted four‐block randomization procedure to supplement with propolis tablets, two tablets/day (500 mg propolis/day) (n = 30) or identical placebo tablets (n = 30) for 12 weeks in 2021 until 2022. Data were collected using a demographic questionnaire, blood samples, and a checklist to record the measured parameters. A total of 57 patients completed the trial. ANCOVA test showed that hip circumference (HC)) p = 0.03), fasting insulin (p = 0.007), homeostatic model assessment for insulin resistance (p = 0.004), testosterone (p = 0.004), and low‐density lipoprotein (LDL)/high‐density lipoprotein (HDL) (p = 0.02) were significantly decreased in the propolis versus the placebo group after adjustment for confounders. Although fasting blood glucose (p = 0.04) decreased significantly in the propolis group compared to the placebo, after adjusting for confounders, significance was lost (p = 0.09). Supplementation with propolis elicited positive effects on fasting insulin and insulin resistance, in addition to reducing the testosterone level, LDL/HDL, and HC, in PCOS women.
Unleashing the potential of bio‐nanoparticles from invasive cattail as reinforcement in packaging film to extend the shelf life of poultry meat
Authors: Jacob Rani Baby Salini , Venkatachalam Sivakumar 
Published: September 2023

AbstractGrowing awareness of fossil depletion, plastic pollution, and food spoilage has led to the exploration of bioresources as alternatives for producing packaging films for highly perishable food. In this study, we utilized a novel integrated process using natural‐based solvents to isolate cellulose, hemicellulose, and lignin from cattail leaves, an abundant invasive plant. The process yielded cellulose, hemicellulose, and lignin with recovery yields of 96.2 ± 1.2%, 92.5 ± 1.6%, and 94.3 ± 0.7% and purities of 96.3 ± 0.6%, 97.7 ± 0.9%, and 98.9 ± 0.5%, respectively. Spherical nanoparticles (60–90 nm) were synthesized through ultrasonication and their structural purity were confirmed by FTIR, XRD, and XPS analyses. These nanoparticles were incorporated as reinforcement into chitosan (C) films. Cellulose nanoparticles (CNP) and lignin nanoparticles (LNP) significantly enhanced film tensile strength (up to 27% at 1.5% loading), while hemicellulose nanoparticles (HNP) increased film elongation (up to 42%). The complex structures of HNP and LNP promoted higher free radical formation, resulting in enhanced antioxidant activity of up to 80% and 82%, respectively. LNP‐reinforced films exhibited superior antimicrobial properties due to their polyphenolic structure. Preservation tests were conducted by packaging poultry meat in the films and refrigerating it for 30 days. Poultry meat packed in LNP‐reinforced film maintained its quality within permissible limits throughout the entire 30 day period, while LDPE, plain chitosan, C‐CNP, and C‐HNP films reached consumable limits on the 5th, 10th, 15th, and 25th days, respectively. This study highlights the production of sustainable nanoparticles from invasive crops and their application in the development of active packaging films for fresh poultry meat.
The knowns and unknowns of cardiac autoimmunity in viral myocarditis
Authors: Mone Kiruthiga , Reddy Jay 
Published: September 2023

AbstractMyocarditis can result from various infectious and non‐infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the viruses would have damaged the tissues and be cleared by the immune system. Therefore, viral signatures such as viral nucleic acids and virus‐reactive antibodies may be the only readouts pointing to viruses as potential primary triggers of DCM. Thus, it becomes hard to explain persistent inflammatory infiltrates that might occur in individuals affected with chronic myocarditis/DCM manifesting myocardial dysfunctions. In these circumstances, autoimmunity is suspected, and antibodies to various autoantigens have been demonstrated, suggesting that immune therapies to suppress the autoimmune responses may be necessary. From this perspective, we endeavoured to determine whether or not the known viral causes are associated with development of autoimmune responses to cardiac antigens that include both cardiotropic and non‐cardiotropic viruses. If so, what their nature and significance are in developing chronic myocarditis resulting from viruses as primary triggers.
Constrained control of uncertain nonhomogeneous Markovian jump systems
Authors: Yin Yanyan , Lin Zongli 
Published: September 2023

SummaryThis paper addresses the problem of robust stabilization for uncertain systems subject to input saturation and nonhomogeneous Markovian jumps, where the uncertainties are assumed to be norm bounded and the transition probabilities are time‐varying and unknown. By expressing the saturated linear feedback law on a convex hull of a group of auxiliary linear feedback laws and the time‐varying transition probabilities inside a polytope, we establish conditions under which the closed‐loop system is asymptotically stable. On the basis of these conditions, the problem of designing the state feedback gains for achieving fast transience response with a guaranteed size of the domain of attraction is formulated and solved as a constrained optimization problem with linear matrix inequality constraints. The results are then illustrated by numerical examples including the application to a DC motor speed control example. Copyright © 2017 John Wiley & Sons, Ltd.
Stability analysis and synthesis for linear impulsive stochastic systems
Authors: Luo Shixian , Deng Feiqi , Chen Wu‐Hua 
Published: September 2023

SummaryThis paper presents a general framework for analyzing stability of linear impulsive stochastic systems (LISSs). Some simple mean square stability criteria for the three types of LISSs are firstly derived by analyzing an equivalent system. By exploring the hybrid characteristics of impulsive systems, the novel quasi‐periodic composite polynomial Lyapunov function and the time‐varying discretized Lyapunov function are developed, which leads to unified dwell‐time–based criteria for mean square stability and almost sure stability of LISSs without imposing the stability condition on continuous‐ and discrete‐time dynamics. Next, based on the established stability criteria, the synthesis problem of state‐feedback controller is solved. The computational complexity and the comparison with existing results on the deterministic systems are discussed. Finally, numerical examples are provided to illustrate the usefulness of the proposed results.
Disruptions in self‐regulatory processes predict depression and sleep disturbance in bereaved young adults
Authors: Finkelstein‐Fox Lucy , Park Crystal L. , Eigsti Inge‐Marie , Awao Sayaka , Mancini Anthony D. 
Published: September 2023

AbstractLosing a loved one is both common and profoundly stressful for young adults. Little research has examined the longitudinal course of post‐loss cognitive processing, depression, and sleep difficulties. Further, little is known about the context of other stressors or the role of individual regulatory resources, such as attentional regulation, that might determine whether loss‐related cognitive processing reduces distress. This prospective study examined changes in depression and sleep disturbance over 9 weeks as a function of within‐ and between‐person variation in stress exposure, loss‐related cognitive processing, and attention regulation. Participants were 108 recently bereaved college students completing a lab‐based assessment of attention regulation and four self‐report surveys, spaced three weeks apart. Results revealed that most participants gradually reduced loss‐related processing over the study period, with corresponding improvements in depression and sleep. Stress exposure was associated with increased processing, depression, and sleep disturbance. In exploratory analyses, high attentional alertness and slow re‐orienting strengthened the association of within‐person loss processing with sleep disturbance. Both within‐ and between‐person variation in stress appear to engender risk for a prolonged course of bereavement. Future research should integrate objective attention measures with self‐reported adjustment to stress to illuminate reciprocal links between depression, sleep, and loss‐related cognitive processing.
X‐Site Substituted 2D Cs2Pb(SCN)2Br2 Perovskites for X‐Ray Detection
Authors: Liu Dan , Di Haipeng , Ren Jiwei , Jiang Wei , Li Haibin , Zhao Chen , Xin Deyu , Xing Zhenning , Zheng Xiaojia , Zhao Yiying 
Published: September 2023

Abstract2D Ruddlesden–Popper (RP) perovskites have been intensively investigated due to their superior stability and outstanding optoelectrical properties. However, investigations on 2D RP perovskites are mainly focused on A‐site substituted perovskites and few reports are on X‐site substituted perovskites especially in X‐ray detection field. Here, X‐site substituted 2D RP perovskite Cs2Pb(SCN)2Br2 polycrystalline wafers are prepared and systematically studied for X‐ray detection. The obtained wafers show a large resistivity of 2.0 × 1010 Ω cm, a high ion activation energy of 0.75 eV, a small current drift of 2.39 × 10−6 nA cm−1 s−1 V−1, and charge carrier mobility‐lifetime product under X‐ray as high as 1.29 × 10−4 cm2 V−1. These merits enable Cs2Pb(SCN)2Br2 wafer detectors with a sensitivity of 216.3 µC Gyair−1 cm−2, a limit of detection of 42.4 nGyair s−1, and good imaging ability with high spatial resolution of 1.08 lp mm−1. In addition, Cs2Pb(SCN)2Br2 wafer detectors demonstrate excellent operational stability under high working field up to 2100 V cm−1 after continuous X‐ray irradiation with a total dose of 45.2 Gyair. The promising features such as short octahedral spacing and weak ion migration will open up a new perspective and opportunity for SCN‐based 2D perovskites in X‐ray detection.
Tunable Band Engineering Management on Perovskite MAPbBr3/COFs Nano‐Heterostructures for Efficient S–S Coupling Reactions
Authors: Lin Qianying , Tan Siyi , Zhao Jiwu , Fang Xiao , Wang Ying , Wen Na , Zhang Zizhong , Ding Zhengxin , Yuan Rusheng , Yan Guiyang , Jin Shengye , Long Jinlin 
Published: September 2023

AbstractEfficient artificial photosynthesis of disulfide bonds holds promises to facilitate reverse decoding of genetic codes and deciphering the secrets of protein multilevel folding, as well as the development of life science and advanced functional materials. However, the incumbent synthesis strategies encounter separation challenges arising from leaving groups in the ─S─S─ coupling reaction. In this study, according to the reaction mechanism of free‐radical‐triggered ─S─S─ coupling, light‐driven heterojunction functional photocatalysts are tailored and constructed, enabling them to efficiently generate free radicals and trigger the coupling reaction. Specifically, perovskites and covalent organic frameworks (COFs) are screened out as target materials due to their superior light‐harvesting and photoelectronic properties, as well as flexible and tunable band structure. The in situ assembled Z‐scheme heterojunction MAPB‐M‐COF (MAPbBr3 = MAPB, MA+ = CH3NH2+) demonstrates a perfect trade‐off between quantum efficiency and redox chemical potential via band engineering management. The MAPB‐M‐COF achieves a 100% ─S─S─ coupling yield with a record photoquantum efficiency of 11.50% and outstanding cycling stability, rivaling all the incumbent similar reaction systems. It highlights the effectiveness and superiority of application‐oriented band engineering management in designing efficient multifunctional photocatalysts. This study demonstrates a concept‐to‐proof research methodology for the development of various integrated heterojunction semiconductors for light‐driven chemical reaction and energy conversion.
Efficient Catalysis of Ultrathin Two‐Dimensional Fe2O3–CoP Heterostructure Nanosheets for Polysulfide Redox Reactions
Authors: Pu Jun , Tan Yun , Wang Tao , Gong Wenbin , Gu Cuiping , Xue Pan , Wang Zhenghua , Yao Yagang 
Published: September 2023

AbstractThe “shuttle effect” and slow redox reactions of Li‐S batteries limit their practical application. To solve these problems, a judicious catalyst design for improved battery cycle life and rate performance is essential. Herein, this issue is addressed by modifying the Li‐S battery separator using a 2D Fe2O3–CoP heterostructure that combines the dual functions of polar Fe2O3 and high‐conductivity CoP. The synthesized ultrathin nanostructure exposes well‐dispersed active sites and shortens the ion diffusion paths. Theoretical calculations, electrochemical tests, and in situ Raman spectroscopy measurements reveal that the heterostructure facilitates the inhibition of polysulfide shuttling and enhances the electrode kinetics. A sulfur cathode constructed using the Fe2O3–CoP‐based separator provides an astonishing capacity of 1346 mAh g−1 at 0.2 C and a high capacity retention of ≈84.5%. Even at a high sulfur loading of 5.42 mg cm−2, it shows an area capacity of 5.90 mAh cm−2. This study provides useful insights into the design of new catalytic materials for Li‐S batteries.
Multidimensional Applications and Challenges of Riboswitches in Biosensing and Biotherapy
Authors: Wu Yifan , Zhu Longjiao , Zhang Yangzi , Xu Wentao 
Published: September 2023

AbstractRiboswitches have received significant attention over the last two decades for their multiple functionalities and great potential for applications in various fields. This article highlights and reviews the recent advances in biosensing and biotherapy. These fields involve a wide range of applications, such as food safety detection, environmental monitoring, metabolic engineering, live cell imaging, wearable biosensors, antibacterial drug targets, and gene therapy. The discovery, origin, and optimization of riboswitches are summarized to help readers better understand their multidimensional applications. Finally, this review discusses the multidimensional challenges and development of riboswitches in order to further expand their potential for novel applications.
Antiferroelectricity‐Induced Negative Thermal Expansion in Double Perovskite Pb2CoMoO6
Authors: Zhao Haoting , Pan Zhao , Shen Xi , Zhao Jianfa , Lu Dabiao , Zhang Jie , Hu Zhiwei , Kuo Chang‐Yang , Chen Chien‐Te , Chan Ting‐Shan , Sahle Christoph J. , Dong Cheng , Nishikubo Takumi , Koike Takehiro , Deng Zun‐Yi , Hong Jiawang , Yu Runze , Yu Pu , Azuma Masaki , Jin Changqing , Long Youwen 
Published: September 2023

AbstractMaterials with negative thermal expansion (NTE) attract significant research attention owing to their unique physical properties and promising applications. Although ferroelectric phase transitions leading to NTE are widely investigated, information on antiferroelectricity‐induced NTE remains limited. In this study, single‐crystal and polycrystalline Pb2CoMoO6 samples are prepared at high pressure and temperature conditions. The compound crystallizes into an antiferroelectric Pnma orthorhombic double perovskite structure at room temperature owing to the opposite displacements dominated by Pb2+ ions. With increasing temperature to 400 K, a structural phase transition to cubic Fm‐3m paraelectric phase occurs, accompanied by a sharp volume contraction of 0.41%. This is the first report of an antiferroelectric‐to‐paraelectric transition‐induced NTE in Pb2CoMoO6. Moreover, the compound also exhibits remarkable NTE with an average volumetric coefficient of thermal expansion αV = −1.33 × 10−5 K−1 in a wide temperature range of 30–420 K. The as‐prepared Pb2CoMoO6 thus serves as a prototype material system for studying antiferroelectricity‐induced NTE.
MoS2 Nanoflowers Grown on Plasma‐Induced W‐Anchored Graphene for Efficient and Stable H2 Production Through Seawater Electrolysis
Authors: Dang Van Dien , Putikam Raghunath , Lin Ming‐Chang , Wei Kung‐Hwa 
Published: September 2023

AbstractHerein, it is found that 3D transition metal dichalcogenide (TMD)—MoS2 nanoflowers—grown on 2D tungsten oxide‐anchored graphene nanosheets (MoS2@W‐G) functions as a superior catalyst for the hydrogen evolution reaction (HER) under both acidic and alkaline conditions. The optimized weight ratio of MoS2@W‐G (MoS2:W‐G/1.5:1) in 0.5 M H2SO4 achieves a low overpotential of 78 mV at 10 mA cm–2, a small Tafel slope of 48 mV dec–1, and a high exchange current density (0.321 mA cm⁻2). Furthermore, the same MoS2@W‐G composite exhibits stable HER performance when using real seawater, with Faradaic efficiencies of 96 and 94% in acidic and alkaline media, respectively. Density functional theory calculations based on the hybrid MoS2@W‐G structure model confirm that suitable hybridization of 3D MoS2 and 2D W‐G nanosheets can lower the hydrogen adsorption: Gibbs free energy (∆GH*) from 1.89 eV for MoS2 to –0.13 eV for the MoS2@W‐G composite. The excellent HER activity of the 3D/2D hybridized MoS2@W‐G composite arises from abundance of active heterostructure interfaces, optimizing the electrical configuration, thereby accelerating the adsorption and dissociation of H2O. These findings suggest a new approach for the rational development of alternative 3D/2D TMD/graphene electrocatalysts for HER applications using seawater.