bluuebunny/crossref_metadata_2025_split huggingface dataset:
Textile wastewater treatment plant performance assessment using time-function based effluent quality index and multiple regression models
Authors: Wondim Tilik Tena , Dzwairo Rimuka Bloodless , Aklog Dagnachew , Wakjira Eshetu Janka , Samarakoon Gamunu , Dereseh Mekuria Mulusew 
Published: June 2023

Abstract
Extensive water and chemicals are used in the textile industry processes. Therefore, treatment of textile wastewater is vital to protect the environment, maintain the public health, and recover resources. However, due to inadequate quality data, inexperienced plant operators, and inconsistent measurements, a real-time prediction of effluent quality of a textile wastewater treatment plant is difficult. Thus, the aim of this study was to characterize the wastewater physicochemical properties and evaluate the performance of the textile factory wastewater treatment plant (WWTP) in Bahir Dar, Ethiopia. Inlet and outlet of the WWTP, samples were collected for six months and analyzed on-site and in a laboratory for parameters including, dissolved oxygen, pH, temperature, total Kjeldhal nitrogen (TKN), chemical oxygen demand (COD), biochemical oxygen demand (BOD5), total suspended solids (TSS), total nitrogen (TN), total phosphorous (TP), nutrients, and metallic compounds. The TSS, BOD5, COD, TP, nitrite, ammonia, and total chromium result were above the discharge limit with 73.2 mg/L, 48.45 mg/L, 144.08 mg/L, 7.9 mg/L, 1.36 mg/L, 1.96 mg/L, and 0.16 mg/L, respectively. Multiple regression models were developed for each overall, net moving average and instantaneous effluent quality index (EQI). The predictor parameters BOD5, TN, COD, TSS, and TP (R2 = 0.995 to 1.000) estimated the net pollution load as 492.55 kg/d and 655.44 kg/d. Except TN, TKN, and NO3, the remaining six performance parameters were violating the permissible limit daily. Furthermore, the overall plant efficiency was predicted as 38 % and 42 % for the moving average and instantaneous EQI, respectively. Our study concluded that the integrated regression models and EQI can easily estimate the plant efficiency and daily possible pollution load.
Unraveling the Effects of the COVID-19 Pandemic on the Burden of Respiratory Syncytial Virus in a Tertiary Hospital in Catalonia, Spain: Season 2022-2023 Analysis
Authors: Perramon-Malavez Aida , Rioja Victor Lopez , Creus Anna , Andrés Cristina , Montañola-Sales Cristina , Vila Jorgina , Lera Esther , Antón Andrés , Worner Núria , Balcells Joan , Piñana Maria , Soler-Palacin Pere , Prats Clara , Soriano-Arandes Antoni 
Published: June 2023

Abstract
Purpose: Respiratory Syncytial Virus (RSV) associated infections have historically been the cause of seasonal paediatric hospital departments’ saturation. During the COVID-19 pandemic, the community incidence of RSV was reduced, thus the hospital burden. The last RSV season broke out in early October 2022, 4-6 weeks earlier than in pre-pandemic years, and was thought to be the most demanding to date. Our aim was to assess the burden of RSV-related hospitalizations on a referral hospital (Catalonia, Spain) during the pre-pandemic years and the most recent 2022-2023 season.
Methods: We analysed the paediatric hospital and intensive care (PICU) admissions data (January 2016 – January 2023) of a tertiary referral hospital in Catalonia, Spain. All-cause pediatric admissions, admissions related to confirmed RSV infections, and occupancy-related variables were collected.
Results and conclusion: RSV-related hospitalizations incidence was lower during the pandemic years, particularly in 2020. The majority of RSV cases within an epidemic peak primarily affected children ≤3 months. Although the number of daily admissions during the last RSV 2022-2023 season was not higher than in the pre-pandemic years, the mean occupancy of the hospital was significantly higher (p= 0.04) due to a longer period of days with more than 20 RSV infected children inpatients per day.
Integrated network pharmacology and cellular assay reveal the biological mechanisms of Limonium sinense (Girard) Kuntze against breast cancer
Authors: Zhao Hualong , Wang Siyuan , Williamson Philip T.F. , Ewing Rob M. , Tang Xinhui , Wang Jialian , Wang Yihua 
Published: June 2023

Abstract
Background
Limonium Sinense (Girard) Kuntze (L. sinense) has been widely used for the treatment of anaemia, bleeding, cancer, and other disorders in Chinese folk medicine. Although L. sinense has shown promising inhibitory effects on breast cancer, the exact mechanism underlying its anticancer properties remains unclear.
Methods
The active ingredients of L. sinense were collected from published literature, and the potential targets related to L. sinense were obtained from public databases. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and DisGeNET enrichment analyses were performed to explore the underlying mechanisms. Molecular docking, cellular experiments, and Gene Expression Omnibus (GEO) datasets were employed to further evaluate the findings.
Results
A total of 15 active ingredients of L. sinense and their corresponding 389 targets were obtained. Enrichment and network analyses revealed that the biological effects of L. sinense were primarily associated with breast cancer. Apigenin within L. sinense was found to potentially play a key role against cancer. Cellular experiments demonstrated that the L. sinense ethanol extract (LSE) exhibited a significant growth inhibitory effect on multiple breast cancer cell lines in both 2D and 3D cultures. Additionally, analysis of GEO datasets validated the significant enrichment of breast cancer and several cancer-related pathways upon treatment with Apigenin in human breast cancer cells.
Conclusion
This study predicts the biological activities of L. sinense and demonstrates the inhibitory effect of LSE on breast cancer cells, highlighting the potential application of L. sinense in cancer treatment.
Encirclements of Property Rights Through Economic Complexity in an Umbrella of Justice and Governance: An Empirical Analysis
Authors: Aslam Aribah , Ghouse Ghulam , Khan Bismillah 
Published: June 2023

Abstract
This research paper addresses the complex relationship between governance, justice, and violent crime in high middle-income countries. By analyzing panel data spanning the years 2012 to 2020 and using the Generalized Method of Moments (GMM) technique, this study offers valuable insights into the underlying causes of violent crime and its impact on economic well-being. The study posits three main contentions: first, that countries with exclusive political and economic institutions may have weak governance and judicial systems, allowing corrupt practices to thrive. Second, the study explores the indirect relationship between justice and governance and violent crime. Lastly, it examines the role of institutions in mitigating violent crime. Empirical findings reveal that institutions such as justice and governance play a critical role in curtailing violent crime in high middle-income countries. Moreover, efficient per capita income reinforces the importance of institutions in this context. Additionally, the study finds that education, economic complexity, and remittances have a negative and significant relationship with violent crime. Conversely, the urban population has a positive yet insignificant relationship with the crime rate. The study concludes by recommending that the selected countries prioritize promoting institutional efficiency and expanding access to education. These measures could help combat violent crime and foster greater economic prosperity for these countries.
Disentangling effects of anthropogenic disturbance and community structure on multi-pathogen dynamics in tropical cave-dwelling bat communities
Authors: Vicente-Santos Amanda , Ledezma-Campos Paula , Rodríguez-Herrera Bernal , Corrales-Aguilar Eugenia , Czirják Gábor Á. , Civitello David J. , Gillespie Thomas R. 
Published: June 2023

Abstract
A major challenge in ecology and evolution is to disentangle the known effects of community structure and habitat degradation on disease prevalence, as they often act simultaneously in natural systems. However, cave-dwelling bats persist in degraded habitats, providing a unique opportunity to examine these dual effects. We evaluated how disturbance and cave complexity influenced bat community composition and the prevalence of multiple pathogens at the community level. During wet and dry season surveys of 15 caves in Costa Rica along a gradient of anthropogenic disturbance, we collected samples from 1,238 adult individuals, representing 17 species from four families. We determined the infection prevalence of four common and divergent pathogens: Bartonella (19.7%), Leptospira (22.7%), Trypanosoma (32.0%), and microfilaria (6.6%). Cave complexity, but not disturbance, predicted bat community composition—however, degraded habitats sustained smaller bat populations. Pathogens responded differently to habitat quality, cave complexity, season, species richness, and bat density. For bat richness, we found a negative association with Bartonella prevalence, but a positive association with Trypanosoma and microfilaria and no association with Leptospira. Our work provides insight into the complex patterns of pathogen dynamics and bat community ecology in changing environments by developing a distinctive framework using a multi-host, multi-pathogen system.
Vibration load of the feller buncher machine operator during technological transfers without load
Authors: Александров В.А. , Александров А.В. , Бучников А.А. 
Published: June 2023

Разработана динамическая модель системы «Оператор - валочно- пакетирующая машина». Математическое описание составлено в форме уравнения Лагранжа 2-го рода. Система уравнений решена относительно упругой деформации спинки сиденья оператора методом Рунге-Кутта, с помощью среды программирования MathCAD. Апробация модели осуществлена на примере серийно выпускаемых валочно-пакетирующих машин ЛП-19А.
A dynamic model of the "operator-feller-buncher machine-object of labor-tree" has been developed. The mathematical description is in the form of the Lagrange equation of the second kind. The system of equations is solved for the elastic deformation of the operator's seat back by the Runge-Kutta method, using the MathCAD programming environment. Approbation of the model was carried out on the example of commercially available feller-bunchers machines LP-19A.
Contando história: Uma experiência de ensino colaborativo na educação básica
Authors: Venturini Medeiros Ronise , De Oliveira Pavão Sílvia Maria , Neves Picada Ângela Balbina 
Published: June 2023

Este estudo apresenta um recorte das atividades desenvolvidas pela Educação Especial em uma escola de Educação Básica da rede municipal de ensino de uma cidade do interior do Rio Grande do Sul, na qual uma das autoras atua como professora de Educação Especial. Tem-se como objetivo identificar em que medida o Ensino Colaborativo potencializa a Educação escolar inclusiva na Educação Básica. Para tal, optou-se por uma pesquisa de abordagem qualitativa, do tipo pesquisa participante, com análise de caráter descritivo. Discute-se que as práticas pedagógicas realizadas na perspectiva do Ensino Colaborativo implicam na relação entre professor de Educação Especial e de sala de aula regular, colaborando positivamente no processo de ensino-aprendizagem de todos os alunos, potencializando o aprender e contribuindo para a efetivação do processo de inclusão escolar.
Dentre as conclusões, observa-se que o Ensino Colaborativo pode contribuir e potencializar a Educação escolar inclusiva, desde que encontre um contexto aberto e acessível para a realização desta prática de ensino. Dentre os aspectos observados ao longo da pesquisa, destacam-se a possibilidade de trocas entre os professores e os alunos e a democratização do processo de ensino-aprendizagem.
Análise microbiológica da carne comercializada nos açougues da cidade de Nampula, Moçambique
Authors: Kinyamba Junior Ndjate , Vintuar Pompílio Armando , Serrote Caetano Miguel Lemos , Mussalama Adélio Zeca 
Published: June 2023

As condições higiênico-sanitárias precárias que caracterizam os açougues de Moçambique contribuem para a contaminação de carnes, constituindo um atentado à saúde dos consumidores. Este estudo visou realizar uma análise microbiológica da carne bovina comercializada nos açougues da cidade de Nampula, Moçambique. Foram analisadas, sob padrões laboratoriais ISO, a carne bovina fresca e as zaragatoas de sete açougues licenciados. A análise revelou que 100% das amostras de todos os açougues foram contaminadas por bactérias aeróbias mesófilas, porém, no limite aceitável de contaminação. Cinco açougues apresentaram valores superiores a 1,5 × 106 UFC/g de contaminação. Para Staphylococcus aureus, todas as amostras apresentaram valores superiores a 100 UFC/g; para Escherichia coli, quatro amostras apresentaram valores acima dos limites aceitáveis; e 71% das amostras foram contaminadas por Salmonella spp. Quanto aos utensílios e equipamentos, houve contaminação em 14% das amostras. Assim, recomenda-se a implementação de boas práticas de manipulação de carne nos açougues da cidade de Nampula, de modo a promover a obtenção de carne de qualidade pelos consumidores.
1-OR: Burden of Hypoglycemia in Medicare Advantage Beneficiaries with Type 2 Diabetes Not on Insulin Therapy
Authors: HANNAH KATIA , NEMLEKAR POORVA , BUSHMAN JESSE S. , NORMAN GREGORY J. 
Published: June 2023

In 2022, the Centers for Medicare & Medicaid Services released proposed changes to Medicare’s continuous glucose monitoring (CGM) coverage policy, making individuals with a history of problematic hypoglycemia eligible for CGM coverage, irrespective of insulin use. This study estimated the burden of hypoglycemia in Medicare Advantage (MA) beneficiaries with type 2 diabetes not on insulin therapy (T2D-NIT). We retrospectively analyzed US healthcare claims data using Optum’s Clinformatics® database. MA beneficiaries with T2D-NIT were identified in the 15 years from 2007 to 2021. Hypoglycemia-related encounters (HREs) were those accompanied by a hypoglycemia-specific ICD9/10 diagnosis code in any position on the claim. HREs following the first claim related to T2D were enumerated and classified by setting (ambulatory or inpatient/emergency department [ED]). MA beneficiaries with T2D-NIT included a study population of 2,708,762 individuals (53% female, 65.2% White) followed for an average of 5 years. HREs were identified in 19.4% (n=525,741) of individuals, of whom 15.8% (n=428,734) had ambulatory encounter(s) and 5.41% (n=146,454) had inpatient/ED encounter(s). Prior to the first HRE, 26.5% (n=142,918) were using a sulfonylurea (SU), 35.9% (n=193,677) had evidence of chronic kidney disease, and 11.5% (n=62,404) had chronic kidney disease and were using a SU. These findings show that HREs are prevalent in the T2D-NIT population and identify a large number of patients who may benefit from CGM. Since &gt;80% of HREs occur in the ambulatory setting and &gt;70% occur in patients not taking SUs, primary care providers should be aware of the latest eligibility criteria for Medicare’s coverage of CGM and not restrict CGM to SU users. The generalizability of these findings is limited to the data source and may not be representative of the overall MA T2D-NIT or Medicare fee-for-service populations.

Disclosure
K.Hannah: Employee; Dexcom, Inc. P.Nemlekar: Employee; Dexcom, Inc. J.S.Bushman: Employee; Dexcom, Inc. G.J.Norman: Employee; Dexcom, Inc.

Funding
Dexcom, Inc.
1001-P: Adherence and Persistence to Basal Insulin Therapy Is Associated with Decreased Health Care Utilization in Adults with Type 2 Diabetes
Authors: NIELSEN NICK F. , ARODA VANITA R. , MANGLA KAMAL K. , DIVINO VICTORIA , NAMVAR TARLAN , RAJPURA JIGAR R. 
Published: June 2023

Objectives: Lack of adherence and persistence to prescribed therapy impact achievement of glycemic goals. This study aimed to assess the association between adherence and persistence to basal insulin therapy with healthcare resource utilization (HCRU) among adults with type 2 diabetes (T2D).
Methods: This was an observational, retrospective cohort study of commercially insured US patients using IQVIA PharMetrics® Plus claims data. We identified adults with T2D initiating basal insulin therapy between January 1, 2016 and December 31, 2018. Adherence/non-adherence and persistence/non-persistence were assessed per established definitions. Demographic and clinical characteristics were assessed over the one-year baseline period (prior to initiation). Inverse probability of treatment weighting (IPTW) was used to adjust for confounding by adherence and persistence status. Post-IPTW, all-cause medical HCRU and costs in the one-year follow-up period were compared across cohorts.
Results: The final sample consisted of 64,953 patients: 42% and 58% met criteria for adherence and non-adherence, respectively; 57% and 43% met criteria for persistence and non-persistence, respectively. The proportion of patients with ≥1 hospitalization was lower for the adherence and persistence cohorts compared to their reference groups (adherence: 12.2% vs. 13.8%; persistence: 12.5% vs. 14.2%, both P&lt;0.0001); for these patients, mean hospitalization days were lower among adherence and persistence cohorts (adherence: 10.1 vs. 13.2; persistence: 10.4 vs. 13.8, both P&lt;0.0001). Total mean medical costs were also lower (adherence: $16,118 vs. $17,991; persistence: $16,459 vs. $18,399, both P&lt;0.0001), driven by lower acute care costs (adherence: $6,210 vs. $7,775; persistence: $6,385 vs. $8,171, both P&lt;0.0001).
Conclusions: In this study, adherence and persistence to basal insulin therapy was associated with lower HCRU and costs, particularly for acute care.

Disclosure
N.F.Nielsen: Employee; Novo Nordisk A/S, Coloplast A/S. V.R.Aroda: Consultant; Applied Therapeutics Inc., Fractyl Health, Inc., Novo Nordisk, Pfizer Inc., Sanofi, Other Relationship; Janssen Pharmaceuticals, Inc., Research Support; Applied Therapeutics Inc., Eli Lilly and Company, Fractyl Health, Inc., Novo Nordisk, Sanofi. K.K.Mangla: Employee; Novo Nordisk A/S, Stock/Shareholder; Novo Nordisk A/S. V.Divino: Employee; IQVIA Inc. T.Namvar: None. J.R.Rajpura: Employee; Novo Nordisk.
1007-P: Employment and Work Conditions among U.S. Adults with Diagnosed Diabetes Pre- and Post-COVID-19 Pandemic
Authors: TANG SHICHAO , CHEN YU , ZHANG PING 
Published: June 2023

Persons with diabetes mellitus (DM) have been disproportionately impacted by the COVID-19 pandemic compared with those without diabetes. How the pandemic has affected the employment and work conditions of persons with DM is unknown. Using 2018-2021 National Health Interview Survey data, we examined changes in the likelihood of being employed, having paid sick leave, and changes in work hours per week before and after the pandemic among US adults aged 18-64 years with DM using Chi-squared or t-tests. We also examined the likelihood of having social distance measures in place at work and working closer than 6 feet to other people during the pandemic. We compared the changes in the gap of these measures between persons with and without DM before and after the pandemic using multivariable linear regression. Compared with the pre-pandemic period, persons (men and women, and those with and without DM) worked longer hours and were more likely to have paid sick leave after the pandemic. Changes in the gap between persons with and without diabetes in those measures were not statistically significant (see table). Men with DM were more likely to work closer than 6 feet to others than men without DM. The COVID-19 pandemic does not appear to have affected labor market outcomes for persons with DM relative to those without DM. Future research may confirm this finding and explore reasons to explain the identified patterns.

Disclosure
S.Tang: None. Y.Chen: None. P.Zhang: None.
1008-P: The Relationship between Glycemic Control and Total Health Care Costs for Adults with Type 2 Diabetes in the U.S.
Authors: BAE JAY P. , THIEU VIVIAN , LAGE MAUREEN J. , BOYE KRISTINA 
Published: June 2023

Introduction: The estimated economic costs of diabetes was $327B in 2017 and is forecasted to increase to $494B by 2030. This study compares total health care costs for adults with T2D with glycemic control (HbA1c &lt; 7%) compared to poor glycemic control (HbA1c ≥ 7%).
Methods: The Optum’s de-identified Clinformatics® Data Mart database from 1/1/2015 - 6/30/2021 was used to identify a cohort of adults with T2D with an index date of first recorded HbA1c test between 1/1/2016 - 7/1/2020 and continuous insurance from 1 year prior through 1 year post index date. Patients with glycemic control were propensity score matched to patients with poor glycemic control. Generalized linear models and two-part models examined all-cause total medical costs in 2021 dollars as well as outpatient, drug, and acute care costs over the 1- year post-period.
Results: Results from the matched cohort (N=59,830) indicate that glycemic control was associated with significantly lower annual total, acute, and drug costs but significantly higher outpatient costs (see Figure 1; all P&lt;0.05). Sensitivity analyses using ≤ 6.5% and &lt; 8% HbA1c thresholds showed that being below threshold was associated with significantly lower total medical costs.
Conclusion: Glycemic control was associated with significantly lower annual all-cause total medical costs. Results suggest economic benefits associated with having HbA1c at or below target.

Disclosure
J.P.Bae: None. V.Thieu: None. M.J.Lage: Consultant; Eli Lilly and Company. K.Boye: Employee; Eli Lilly and Company.
101-OR: Systematic Intraoperative Bone Sampling Increases Healing Chances in Diabetic Foot Osteomyelitis
Authors: IACOPI ELISABETTA , GIANGRECO FRANCESCO , LEONILDI ALESSANDRO , ORTENZI VALERIO , ROBERTO SUARDI LORENZO , PIERUZZI LETIZIA , GORETTI CHIARA , BARNINI SIMONA , FALCONE MARCO , NACCARATO GIUSEPPE , PIAGGESI ALBERTO 
Published: June 2023

Aim: We aimed to evaluate if a proactive multidisciplinary diagnostic program could improve outcomes in the management of multidrug resistant (MDR) diabetic foot (DF) osteomyelitis (OM).
Methods: We evaluated all the consecutive patients undergoing surgical procedure for OM July-December 2021 in our department (Group A). Intraoperative bone specimens were collected for microbiological and histological analysis on whose results antibacterial therapy was decided. Controls were patients admitted January-June 2021 with same indications (Group B) but with no systematic intraoperative bone sampling. Clinical and demographic characteristics, procedures, healing rate (HR) and healing time (HT), were compared between the groups.
Results: We derived data from 89 patients: 46 in Group A [51.7%; age 68.8±13.5 yrs; diabetes duration (DD) 19.6±11.6 yrs Hba1c 8.7±4.8%] and 43 in Group B [48.3%; age 70.4±12.9 yrs; DD 18.8±12.1 yrs; Hba1c 8.4±5.1%]. No differences in demographic and clinical features, i.e. chronic kidney disease (39.1% vs 37.2%, p=ns), ischemic cardiac disease (41.3% vs 39.5%, p=ns), peripheral arterial disease (65.2% vs 67.4%, p=ns) and peripheral revascularizations (56.5% vs 53.4%, p=ns). Group A had a higher healing rate (80.4% vs 60.4%, p=0.0021) and a shorter healing time (67±41 days vs 134±92 days, p=0.020) compared to Group B.
Conclusions: Systematic intraoperative bone sampling for culture and histology, and consequent antibiotic adjustment, increases healing rates and reduces healing times in DF patients undergoing surgical debridement for OM.

Disclosure
E.Iacopi: None. G.Naccarato: None. A.Piaggesi: None. F.Giangreco: None. A.Leonildi: None. V.Ortenzi: None. L.Suardi: None. L.Pieruzzi: None. C.Goretti: None. S.Barnini: None. M.Falcone: None.