bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooling potential for hot climates by utilizing thermal management of compressed air energy storage systems
Authors: Alami Abdul Hai , Orhan Mehmet , Al Rashid Rashid , Yasin Ahmad , Radwan Ali , Ayoub Mohamad , Abdelkareem Mohammad Ali , Alashkar Adnan 
Published: December 2022

AbstractThis work presents findings on utilizing the expansion stage of compressed air energy storage systems for air conditioning purposes. The proposed setup is an ancillary installation to an existing compressed air energy storage setup and is used to produce chilled water at temperatures as low as 5 °C. An experimental setup for the ancillary system has been built with appropriate telemetric devices to measure the temporal temperature variation, which consequently can be used to calculate the heat transfer and available cooling capacity. The system is compared to commercially available compression cooling air conditioners, and the potential of replacing them is promising, as one ton of conventional cooling can be replaced with a 500-L (0.5 m3) air tank at 20 bar operating for an hour. More tanks can be added to extend the operational viability of the system, which is also serving the original purpose of storing energy from grid excess or from solar photovoltaic panels. The thermal management has had the added benefit of increasing the roundtrip efficiency of the storage system from 31.4 to 35.2%, along with handling a portion of the cooling load.
Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority study
Authors: Shitara Hitoshi , Tajika Tsuyoshi , Kuboi Takuro , Ichinose Tsuyoshi , Sasaki Tsuyoshi , Hamano Noritaka , Kamiyama Masataka , Yamamoto Atsushi , Kobayashi Tsutomu , Takagishi Kenji , Chikuda Hirotaka 
Published: December 2022

AbstractGlenohumeral internal rotation deficit (GIRD) and weakness in prone external rotation are risk factors for shoulder and elbow injuries in high school baseball pitchers. While a shoulder-stretching prevention program to improve GIRD decreases the injury rate, the effects of external rotation strength remain unclear. This non-inferiority (NI) study investigates the hypothesis that external rotation strength training is not inferior to sleeper stretching for shoulder and elbow injury prevention in high school baseball pitchers. Participants were randomly allocated to the stretching (n = 62; active control group) and muscle-training (n = 51) groups. Specific exercises were performed each night. Elbow and shoulder injuries were monitored for 150 days. Kaplan–Meier survival curves were generated, and the hazard ratios (HRs) for injury occurrence were calculated using multivariate Cox regression. The log-rank test was used to compare the injury-free time. A one-sided NI test using a fixed NI margin was performed (significance level, P = 0.025). The injury rates were 22.6% (n = 14) in the stretching group and 9.8% (n = 5) in the muscle-training group. The muscle-training group had a lower injury rate (P < 0.001) and a lower risk of injury than the stretching group (HR = 0.489). Therefore, external rotation muscle strength training is not inferior to stretching for preventing baseball-related arm injuries.
The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress
Authors: Bhattacharya Udayan , Thavathiru Elangovan , Neizer-Ashun Fiifi , Xu Chao , Gatalica Zoran , Dwivedi Shailendra Kumar Dhar , Dey Anindya , Mukherjee Priyabrata , Bhattacharya Resham 
Published: December 2022

AbstractThe ubiquitin-specific peptidase 10 (USP10) plays a context-specific, pro or anti-tumorigenic role in different malignancies. However, the role of USP10 in pancreatic cancer remains unclear. Our protein and RNA level analysis from archived specimens and public databases show that USP10 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and expression correlates with poor overall patient survival. Phenotypically, silencing USP10 decreased viability, clonal growth and invasive properties of pancreatic cancer cells. Mechanistically, silencing USP10 upregulated BiP and induced endoplasmic reticulum (ER) stress that led to an unfolded protein response (UPR) and upregulation of PERK, IRE1α. Decreased cell viability of USP10 silenced cells could be rescued by a chemical chaperone that promotes protein folding. Our studies suggest that USP10 by protecting pancreatic cancer cells from ER stress may support tumor progression.
Palau’s warmest reefs harbor thermally tolerant corals that thrive across different habitats
Authors: Rivera Hanny E. , Cohen Anne L. , Thompson Janelle R. , Baums Iliana B. , Fox Michael D. , Meyer-Kaiser Kirstin S. 
Published: December 2022

AbstractOcean warming is killing corals, but heat-tolerant populations exist; if protected, they could replenish affected reefs naturally or through restoration. Palau’s Rock Islands experience consistently higher temperatures and extreme heatwaves, yet their diverse coral communities bleach less than those on Palau’s cooler outer reefs. Here, we combined genetic analyses, bleaching histories and growth rates ofPoritescf.lobatacolonies to identify thermally tolerant genotypes, map their distribution, and investigate potential growth trade-offs. We identified four genetic lineages ofP. cf.lobata. On Palau’s outer reefs, a thermally sensitive lineage dominates. The Rock Islands harbor two lineages with enhanced thermal tolerance; one of which shows no consistent growth trade-off and also occurs on several outer reefs. This suggests that the Rock Islands provide naturally tolerant larvae to neighboring areas. Finding and protecting such sources of thermally-tolerant corals is key to reef survival under 21stcentury climate change.
A new confuciusornithid bird with a secondary epiphyseal ossification reveals phylogenetic changes in confuciusornithid flight mode
Authors: Wang Renfei , Hu Dongyu , Zhang Meisheng , Wang Shiying , Zhao Qi , Sullivan Corwin , Xu Xing 
Published: December 2022

AbstractThe confuciusornithids are the earliest known beaked birds, and constitute the only species-rich clade of Early Cretaceous pygostylian birds that existed prior to the cladogenesis of Ornithothoraces. Here, we report a new confuciusornithid species from the Lower Cretaceous of western Liaoning, northeastern China. Compared to other confuciusornithids, this new species and the recently reported Yangavis confucii both show evidence of stronger flight capability, although the wings of the two taxa differ from one another in many respects. Our aerodynamic analyses under phylogeny indicate that varying modes of flight adaptation emerged across the diversity of confuciusornithids, and to a lesser degree over the course of their ontogeny, and specifically suggest that both a trend towards improved flight capability and a change in flight strategy occurred in confuciusornithid evolution. The new confuciusornithid differs most saliently from other Mesozoic birds in having an extra cushion-like bone in the first digit of the wing, a highly unusual feature that may have helped to meet the functional demands of flight at a stage when skeletal growth was still incomplete. The new find strikingly exemplifies the morphological, developmental and functional diversity of the first beaked birds.
Recurrent RNA edits in human preimplantation potentially enhance maternal mRNA clearance
Authors: Ding Yang , Zheng Yang , Wang Junting , Li Hao , Zhao Chenghui , Tao Huan , Li Yaru , Xu Kang , Huang Xin , Gao Ge , Chen Hebing , Bo Xiaochen 
Published: December 2022

AbstractPosttranscriptional modification plays an important role in key embryonic processes. Adenosine-to-inosine RNA editing, a common example of such modifications, is widespread in human adult tissues and has various functional impacts and clinical consequences. However, whether it persists in a consistent pattern in most human embryos, and whether it supports embryonic development, are poorly understood. To address this problem, we compiled the largest human embryonic editome from 2,071 transcriptomes and identified thousands of recurrent embryonic edits (>=50% chances of occurring in a given stage) for each early developmental stage. We found that these recurrent edits prefer exons consistently across stages, tend to target genes related to DNA replication, and undergo organized loss in abnormal embryos and embryos from elder mothers. In particular, these recurrent edits are likely to enhance maternal mRNA clearance, a possible mechanism of which could be introducing more microRNA binding sites to the 3’-untranslated regions of clearance targets. This study suggests a potentially important, if not indispensable, role of RNA editing in key human embryonic processes such as maternal mRNA clearance; the identified editome can aid further investigations.
Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma
Authors: Keppler-Hafkemeyer Andrea , Greil Christine , Wratil Paul R. , Shoumariyeh Khalid , Stern Marcel , Hafkemeyer Annika , Ashok Driti , Hollaus Alexandra , Lupoli Gaia , Priller Alina , Bischof Marie L. , Ihorst Gabriele , Engelhardt Monika , Marks Reinhard , Finke Jürgen , Bertrand Hannah , Dächert Christopher , Muenchhoff Maximilian , Badell Irina , Emmerich Florian , Halder Hridi , Spaeth Patricia M. , Knolle Percy A. , Protzer Ulrike , von Bergwelt-Baildon Michael , Duyster Justus , Hartmann Tanja N. , Moosmann Andreas , Keppler Oliver T. 
Published: December 2022

AbstractIndividuals with hematologic malignancies are at increased risk for severe coronavirus disease 2019 (COVID-19), yet profound analyses of COVID-19 vaccine-induced immunity are scarce. Here we present an observational study with expanded methodological analysis of a longitudinal, primarily BNT162b2 mRNA-vaccinated cohort of 60 infection-naive individuals with B cell lymphomas and multiple myeloma. We show that many of these individuals, despite markedly lower anti-spike IgG titers, rapidly develop potent infection neutralization capacities against several severe acute respiratory syndrome coronavirus 2 variants of concern (VoCs). The observed increased neutralization capacity per anti-spike antibody unit was paralleled by an early step increase in antibody avidity between the second and third vaccination. All individuals with hematologic malignancies, including those depleted of B cells and individuals with multiple myeloma, exhibited a robust T cell response to peptides derived from the spike protein of VoCs Delta and Omicron (BA.1). Consistently, breakthrough infections were mainly of mild to moderate severity. We conclude that COVID-19 vaccination can induce broad antiviral immunity including ultrapotent neutralizing antibodies with high avidity in different hematologic malignancies.
The relationship between miRNA-210 and SCN1B in fetal rats with hypoxic-ischemic brain injury
Authors: Al-Ward Hisham , Liu Ning , Omorou Moussa , Huang Yiwei , Chen Wei , Liu Chun-Yang , Lv Shaochun , Murshed Abduh , Shaher Fahmi , Li Yao , Zhang Yuxuan , Lu Linxia , Gao Wenxia , Sun Yi Eve , Xu Hui 
Published: December 2022

AbstractHypoxic-ischemic brain injury contributes to major neurodevelopmental disorders and is one of the leading causes of seizures, which substantially results in neurodevelopmental impairments with long-lasting outcomes and is one of the main causes of death in neonates. We aimed to investigate the correlation between miRNA-210 and SCN1B, a voltage-gated sodium channel gene, in brain tissue of fetal rats with hypoxic-ischemic brain injury. We found that after 10 min of hypoxia-ischemia, all reperfusion groups showed different degrees of damage. The degree of the injury increased in all the groups after 30 min of hypoxia-ischemia. Those changes include changes in the pericellular lumen, capillaries in the cortex, erythrocytes, enlarged pericellular lumen, the enlarged pericapillary lumen in the cortex, edema around glial cells, enlarged gap to form multiple necrotic foci, deformation of neurons, and loss of cell structure. The expression levels of HIF-1α, miRNA-210, and HIF-1α mRNA were higher in the hypoxic-ischemic groups than that in the control groups, among which the expression levels in the severe group were higher than that in mild group. SCN1B is down-regulated in both the mild and severe groups, and the lowest level was found at 30 min after hypoxia in both groups. MiRNA-210 plays a role in the development of hypoxic-ischemic encephalopathy (HIE) by regulating the expression changes of SCN1B. The brain tissue of fetal rats in the hypoxic-ischemic animal model showed pathological changes of brain injury.
Blockchain technology in energy systems: A state‐of‐the‐art review
Authors: Choobineh Moein , Arabnya Ali , Sohrabi Behrouz , Khodaei Amin , Paaso Aleksi 
Published: December 2022

AbstractBlockchain is a powerful technology to facilitate decarbonization, decentralization, digitalization, and democratization (4D's) of the energy systems of the future. The 4D's are the driving forces of transition into new energy systems that are more sustainable, resilient, efficient, and equitable. Although this technology can be applied to a wide spectrum of applications in the power sector, a set of challenges and limitations still need to be addressed to facilitate a full‐scope implementation in energy systems. This paper presents an overview of blockchain technology from its inception through its most recent evolution and presents a thematic review of state of the art in the application of this technology in power systems. Further, it addresses the barriers preventing the power sector from large‐scale, full‐scope adoption of this technology. Finally, the emerging blockchain trends in the near future will be discussed and its potential to facilitate a secure, decentralized energy trading platform will be investigated.
Structural characteristics of electrohydrodynamic jets induced by a blade‐plane actuator subjected to highly non‐uniform electric fields: Parametric investigation through the particle image velocimetry techniques
Authors: Yan Zelu , Louste Christophe , Traoré Philippe , Wu Jian , Fang Jian'an 
Published: December 2022

AbstractThis study set out to systematically investigate the structural characteristics of plane electrohydrodynamic jets through the particle image velocimetry (PIV) techniques. Due to the wide range of applied voltages and electrode gaps under various experimental conditions, an assessment of the image quality and a statistical analysis of the velocity fields are first performed to ensure the validity of the PIV measurements, which were originally applied purely to fluid mechanics. The results indicate that the time interval between two consecutive images should be pre‐adjusted to reduce the number of uncorrelated vector fields. Moreover, the minimum number of instantaneous fields should be achieved for an accurate calculation of the time‐averaged fields. An equivalent electric field criterion adapted to the asymmetric electrode configuration is defined to find similarities in flow structures under different voltage and electrode gap conditions. As the applied electric field increases, three injection regimes are identified and the current increases almost linearly, indicating a large conduction current component. The decrease in charge density due to recombination proves to be relevant in all cases of this study. Analogous to the parametric analysis approach for classical jets and thermal plumes, the evolution of the coefficients of axial velocity, half‐width and turbulence intensity are investigated.
Morphologic and genetic characterization ofPterygodermatites(Mesopectines)valladaresin. sp. (Nematoda, Rictulariidae), a parasite of the mouseMus musculus(Rodentia, Muridae) from the Canary Islands (Spain)
Authors: Miquel Jordi , Martín-Carrillo Natalia , Ribas Alexis , Sánchez-Vicente Santiago , Feliu Carlos , Foronda Pilar 
Published: December 2022

A new rictulariid nematodePterygodermatites(Mesopectines)valladaresin. sp., parasite of the house mouseMus musculus(Rodentia: Muridae) in the Canary Islands (Spain) is described by means of light and scanning electron microscopy. The new species belongs to the subgenusMesopectinescharacterized by a more or less dorsal orientation of the buccal capsule, the presence of three oesophageal teeth, the morphology of the oral denticles and the Spirurida type of arrangement of caudal papillae in males. The most discriminant characteristics between the new species and the existing species in the subgenusMesopectinesare (a) the number of cuticular projection pairs (62–64), (b) the size of right and left spicules (respectively, 62–90 µm and 123–139 µm), (c) the number of midventral fans in males (3–4), (d) the number of prevulvar/total cuticular projection pairs (38–42/63–71), (e) the posterior differentiation of combs into spines in relation to the position of the vulva and (f) the anterior position of the vulva in relation to the oesophagus-intestine junction in females. Parasitized hosts and geographical distribution are also useful criteria to distinguishP.(Me.)valladaresin. sp. from the remaining species of the subgenus. In addition, thecox1sequence of the new species is provided and compared with available data of related species.
Bilirubin Measurement Through a Smartphone Application in Preterm
Infants
Authors: Ustun Huseyin , Oncel Mehmet Yekta , Kefeli Melike , Akar Melek , Engür Defne 
Published: December 2022

Abstract
Backround Aim of the present study is to evaluate the feasibility and
reliability of an smartphone application for monitore of bilirubin levels in
preterm infants.
Methods Preterm infants hospitalized in the neonatal intensive care unit
with gestational age of<35 weeks were included. Exclusion criteria were
parental reluctance and requirement of phototherapy in the last
12 hours. Measurements were obtained through a smartphone application
(BiliScan) along with simultaneous transcutaneous device (Dräger JM 105)
and venous blood biochemistry.
Results Mean gestational age was 30.8±2.4 weeks and birth weight
was 1622±566 g. Measurements were obtained at a median of 4
(1–21) days of life. Twenty-five infants (19.4%) had ABO
and/or Rh incompatibility and 39 infants (30.2%) required
phototherapy. None of the cases required exchange transfusion. Mean total serum
bilirubin (TSB) level was 8.16±2.60 mg/dL, mean
transcutaneous bilirubin (TcB) level was
8.60±2.70 mg/dL, and the mean bilirubin level measured
by BiliScan was 7.26±2.68 mg/dL. For TSB and TcB
measurements, the intraclass correlation coefficient (ICC) was found to be 0.915
(95% confidence interval 0.835–0.951; p<0.001) and a
strong positive correlation was found between these two measurements. When TSB
and BiliScan measurements were compared, ICC was found to be significant as
0.512 (95% confidence interval 0.353–0.638; p<0.001),
with a moderate correlation.
Conclusions In this study, we evaluated the feasibility and reliability of
a smartphone application for monitoring bilirubin levels in preterm infants.
Although BiliScan measurements reported to display high correlation in term
infants, a moderate correlation was found in the preterm infants. It is an
emerging low-cost, non-invasive alternative for neonatal jaundice monitoring,
however, results should be interpreted with caution in preterm infants.
Wie verbreitet sind komplementärmedizinische Verfahren in
bayerischen Krankenhäusern? Eine Vollerhebung für Bayern
mittels Website-Screening
Authors: Kollikowski Anne , Schiffmann Lisa , Gabriel Katharina , Gágyor Ildikó , Heuschmann Peter , Langhorst Jost , Keil Thomas , Löffler Claudia 
Published: December 2022

Zusammenfassung
Hintergrund In Deutschland werden komplementärmedizinische
Verfahren von bis zu 62% der Patienten genutzt, Art und Ausmaß
dieser Versorgungsangebote im stationären Sektor sind jedoch nicht
bekannt. Die Zielsetzung der Studie war es, eine Statuserhebung zu
komplementärmedizinischen Verfahren mittels Screening der
Internetauftritte aller bayerischen Akutkrankenhäuser jeglicher
Versorgungsstufe durchzuführen, um das Spektrum der angewendeten
komplementärmedizinischen Verfahren zu erfassen.
Methoden Im Jahr 2020 wurde nach dem Vier-Augen-Prinzip ein
unabhängiges und vollständiges Website-Screening aller
bayerischen Akutkrankenhäuser durchgeführt. Angebotene Verfahren
aus der Komplementärmedizin wurden in der Gesamtheit sowie getrennt nach
Fachgebieten analysiert.
Ergebnisse Von 389 bayerischen Krankenhäusern aus der
Akutversorgung boten 82% auf ihrer Website mindestens ein und
66% mindestens drei unterschiedliche komplementärmedizinische
Verfahren an. Am häufigsten wurden Entspannungstechniken (52%),
Akupunktur (44%), Massagen (41%), Bewegungs-, Kunst- und
Musiktherapie (33%, 30% bzw. 28%), meditative
Bewegungsverfahren wie Yoga (30%) und Aromatherapie (29%)
angeboten. Nach Fachgebieten getrennt fanden sich
komplementärmedizinische Verfahren mit 87% am häufigsten
in der Psychiatrie/Psychosomatik (primär Entspannungsverfahren
69%, Bewegungs- und Kunsttherapie jeweils 60%), sowie mit
72% in der Gynäkologie/Geburtshilfe (primär
Akupunktur 64%, Homöopathie 60% und Aromatherapie
41%).
Schlussfolgerungen Die große Mehrheit der bayerischen
Akutkrankenhäuser scheint laut ihrer Internetauftritte auch
komplementärmedizinische Verfahren in der Therapie einzusetzen,
insbesondere bei psychischen Indikationen sowie in der Geburtshilfe und
Gynäkologie. Wie häufig diese im Klinikalltag
tatsächlich zur Anwendung kommen und ob dies sich auch an der aktuellen
Evidenz orientiert, sollte in weiteren Studien untersucht werden.