bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diseño y simulación de un sistema de extracción alternativo para la maquina inyectora de plástico PET de la carrera TSMI.
Authors: Toala Vera Kevin Adrian , Romero Nieto Francisco Joel , Bustamante Sánchez Santiago Isaac 
Published: September 2023

En el instituto superior tecnológico tsáchila de la ciudad de santo domingo, se encuentra una máquina inyectora de plástico PET la cual cuenta con un sistema de extracción neumático, el mismo se encuentra fuera de uso por el motivo que en el área de Mecánica industrial no constan con un compresor el cual es fundamental para este sistema de funcionamiento, nuestro trabajo de investigación se encarga de buscar un nuevo sistema de extracción para darle solución a esta problemática, la cual es diseñar y simular un sistema alternativo para la maquina inyectora de plástico pet, la cual con base de estudios se determinó qué se usará el sistema de extracción mecánico siendo este el más óptimo y eficaz para su funcionamiento. El mismo que se aplicará una vez terminado su proceso simulación que se llevara a cabo en un software de diseño , el mismo se basa en determinar el nivel de cargas y fuerzas de cierre para obtener los datos necesarios y realizar este proceso, con la finalización de este trabajo se dará nuevamente uso a la maquina inyectora de plástico del instituto Tsáchila con los estudiantes de cuarto semestre, en especial tendrá mayor relevancia para la materia de matricería dado que esta asignatura se basa más en realizar prácticas con máquinas de inyección de plástico.
Ringvirkninger av beskrivende radiografer ved bildediagnostisk avdeling
Authors: Lundanes Lise , Sivertsen Ellisiv , Veiby Sigrid , Sitter Beathe 
Published: September 2023

Introduksjon: I Norge utgjør beskrivende radiografer en liten yrkesgruppe, til forskjell fra England hvor de utfører en betydelig andel bidediagnostiske beskrivelser. Ordningen ble startet på 1990-tallet, og det er gjennomført mange tidligere studier som viser at kvaliteten i arbeidet til beskrivende radiografer er god. Imidlertid er det få publiserte studier om andre effekter ved å ha en beskrivende radiograf på avdeling. Hensikten med studien var å finne ut hvilke ringvirkninger som oppleves ved avdelinger med en beskrivende radiograf.

Metode: I denne studien har vi brukt dybdeintervju som metode. Det ble gjennomført intervjuer med tre beskrivende radiografer og tre radiografer som jobbet sammen med beskrivende radiograf. Intervjuobjektene jobbet ved fem forskjellige norske sykehus. Intervjuene foregikk digitalt, og lydopptakene ble transkribert og deretter analysert gjennom systematisk tekstkondensering.

Resultat: Radiografene opplevde de beskrivende radiografene som lett tilgjengelige, og behjelpelige ved spørsmål knyttet til radiograffaglig arbeid på lab. De beskrivende radiografene ble brukt mye til internundervisning på avdelingen og følte selv at de er med på å bevisstgjøre egen og andres kunnskap. Det kom også fram at de beskrivende radiografene fungerer som et bindeledd mellom radiografer og radiologer, og de blir også brukt som en ressurs utenfor egen avdeling.

Konklusjon: Beskrivende radiografer på avdelingen har ført til økt bevisstgjøring av eget kunnskapsnivå både blant de beskrivende radiografene og radiografene. De fungerer også som et bindeledd mellom radiograf og radiolog. Samtidig fører deres tilgjengelighet til flere faglige diskusjoner og tverrfaglig samarbeid på tvers av profesjoner og avdelinger.
Physical activity and health-related quality of life among adults living in Jeddah city Saudi Arabia
Authors: Abdulrashid Ola Akram , Shah Hassan Bin Usman , Baeshen Wijdan Abdulkareem , Aljuaid Sarah Mohammad , Alasmari Enas Awad , Baokbah Rania Ali , Baokbah Reema Ali , Alamoudi Nojoud Mohammed , Alkhelewi Maha Saleh , Turkistani Amal Abdullah , Alharbi Ahmed Abdullah , Alghamdi Abdulrehman Ahmed , Alharthi Fawaz , Alcattan Mohammad , Haikal Amnah Marwan 
Published: September 2023

Background
Physical activity can improve health-related quality of life (HRQoL) in adults. However, the effect of physical activity on quality of life is unclear among the Saudi adult population. The study aimed to determine the association between physical activity and HRQoL in apparently healthy adults in Jeddah, Saudi Arabia.

Methods
This cross-sectional study was conducted among visitors of shopping malls, walking tracks/fitness centres/gyms and governmental hospitals in Jeddah from March to September 2022. Physical activity was measured with the electronic template of the general practice physical activity questionnaire (GPPAQ), while the HRQoL was measured using the 36-Item Short Form Survey (SF-36) questionnaire. A multiple linear regression model investigated the relationship between physical activity and HRQoL.

Results
A total of 693 individuals participated in this study, with a mean age of 36 (±11). Individuals who fall in the active category of the physical activity level were mostly younger men (37% vs 21%), were non-smokers (30% vs 10%) and had no comorbid condition (29% vs 15%). After adjusting for covariates, men (adjusted β 4.43, 95% CI [1.44–7.41]) with higher physical activity levels (active-adjusted β 10.11, 95% CI [5.44–14.77]) had better scores on the physical component summary (PCS). Similarly, mental component summary (MCS) scores for men (adjusted β 6.51, 95% CI [3.40–9.63]) and physical activity levels (active-adjusted β 9.77, 95% CI [4.90–14.64]) were high.

Conclusion
The article reinforces how physical activity contributes towards each dimension of HRQoL. Physical inactivity is a growing public health challenge in Saudi Arabia, affecting all age groups. Investing in innovative strategies and establishing targeted health education programs for academic institutions and communities are required to enhance healthy habits. Additionally, constructing more local sports facilities and concession packages, especially for the females at the gyms, can motivate individuals and promote physical activity.
The Public Perception of the Existence of Coal Mines in South Kalimantan Province, Indonesia
Authors: Asfawi Supriyono , Isworo Slamet 
Published: September 2023

Background and Objectives: The coal mining business is a source of foreign exchange for the country, but it is also thought to have a negative impact on the environment, therefore its continued existence can lead to a variety of public perceptions, both positive and negative. The purpose of this study is to ascertain public perceptions of the coal mining industry's existence and operational implications.
Methods: The survey approach was used in this study to obtain information from respondents. Questions were posed using interviews, questionnaires, and secondary data.
Results: The community leadership structure in the study area is that 35 respondents (48%) follow non-formal leadership, while 38 respondents (52%) follow formal leadership. Most community conflicts are usually triggered by land boundary disputes (38%), and complaints are not responded to (38%), and are resolved by consensus deliberation. Community responses to the impact of coal transportation are health problems (52%), the impact of the presence of coal mines is an increase in the economy (54%), disruption to public roads (66%), noise (66%), and air quality (72%). Coal hauling activities also have an impact on improving business prospects, namely 10% of respondents stated significant (high), 66% moderate, and 24% none. while for the criteria for increasing income, 16% of respondents stated an increase of 62%, a small increase, and 22% did not report. The environmental disturbance parameter stated that 60% of respondents felt disturbed and 40% did not. Environmental management activities on the impact of coal mining operations are 20% of respondents stating good, 34% abstaining and 22% not good.
Conclusion: Community development and empowerment programs around the mine site must be implemented properly, and mine exploration permit holders must strictly adhere to the environmental impact analysis document and environmental management monitoring plan approved by the Ministry of Environment and Forestry.
Exposure to Mycotoxins and Its Importance in Public Health
Authors: Cordero-Mendoza Dulce D. , Hernández-Ceruelos María del Carmen A. , Muñoz-Juárez Sergio , Izquierdo-Vega Alelí Julieta , Vega-Gaitan Indira , Ledezma Jesús Carlos Ruvalcaba 
Published: September 2023

There are a wide variety of toxic compounds that are produced by fungi, known as mycotoxins, which are extremely important because they are found as contaminants in food for human and animal consumption, mycotoxicoses are diseases caused by mycotoxins, exposure to it occurs by ingestion, by skin contact and inhalation, which cause adverse damage to human and animal health, these effects cost millions of dollars annually in global losses in human and animal health, as well as in agricultural products, some mycotoxins of importance in public health they include aflatoxins, trichothecenes, fumonists, ochratoxins, among others.
Objective: The objetive was describe the state of the art on exposure to microtoxins and its importance in public health. The state of the art allows us to conclude that exposure to food contaminated with this type of toxin.
Methodology: A search was carried out in information sources indexed in Crossref, Google scholar Web of Science and in some specific journals such as toxins, Biomedical Journal, and Public Health Journal, using the keywords: mycotoxins, mycotoxigenic foods, aflatoxins, aflatoxigenic foods.
Results and Conclusions: Has a negative impact on public health. In conclusion it is also urgent to search for alternatives to inhibit the growth of said toxigenic fungi and guarantee food quality, free of mycotoxins. and therefore, risks to human health.
Exploration of Exopolysaccharide Producing Bacterial Cultures from Various Drought Affected Region
Authors: Niranjani N. , Kumutha K. , Subhashini R. , Kannan P. , Mini M. L. 
Published: September 2023

Exopolysaccharides (EPS) are extracellular macromolecules secreted by microorganisms play a vital role in improving soil aggregation as well as enhancing the water holding capacity of the soils. This study focuses onto the isolation and characterization of bacterial strains capable of producing Exopolysaccharides (EPS) from drought-affected soil regions across different districts of Tamil Nadu. The core objective revolves around the molecular identification of elite cultures and pivotal genes, responsible for EPS production namely dex (dextransucrase) by using the primer pair WConDex fw and WConDex rev at an amplification size of 1037 bp size. A total of 72 bacterial cultures were isolated from 67 soil samples that are capable of secreting EPS using specific medium.
Clinical Relevance of Antibiotic Prophylaxis in Dental Surgical Procedures: A Systematic Review
Authors: Duarte Ana Vitória Machado , Barbosa Beatriz Soares Leitão , Oliveira Giovana Gisele Costa , Borges Júlia Maria de Sá , Sousa Kamila Gregório da Costa , Cavalcante Milleny Ribeiro da Silva , Araújo Pedro Lucas Rocha dos Santos , Rocha Thales Amon Pereira Duarte , Vieira Felipe Cardoso Rodrigues , Santos Stanley Keynes Duarte dos 
Published: September 2023

Background: Antibiotic prophylaxis is a procedure performed with the use of antibiotics to prevent the patient from contracting some type of infection during surgical procedures.
Aim: To analyze the clinical relevance of using antibiotic prophylaxis before dental surgical procedures.
Methods: This is a systematic review of the qualitative literature in the PubMed, LILACS and Medline databases, using the health descriptors "Antibiotic Prophylaxis", "Dentistry" and "Oral Surgical Procedures" and selected articles in English and Portuguese published between 2018 and 2022. Articles that did not follow the eligibility criteria and that did not address relevant data for the present study were excluded. Abstracts were also excluded; duplicate articles; review articles; meta-analysis and studies not related to dentistry.
Results: After the research, considering the inclusion and exclusion criteria and thematic relevance, 15 articles were selected. Upon analysis, it was found that the effect of antibiotic prophylaxis in case of dental surgeries is small and may not be clinically relevant. Some improvement in postoperative symptoms in dental surgeries can be explained by the decrease in bacterial contamination of the surgical wound, and antibiotic prophylaxis is associated with a lower need for analgesic administration. Amoxicillin is considered the antibiotic of choice for antibiotic prophylaxis in clinical dental practice. In cases of penicillin allergy, clindamycin is often prescribed as a substitute of choice, with lower doses of clindamycin when given over shorter periods of time beneficial in relieving pain and reducing postoperative complications.
Conclusion: Regarding the analyzed studies, it appears that the effect of antibiotic prophylaxis in cases of dental surgery may be small and not clinically relevant. In view of this, more studies on the clinical relevance of antibiotic prophylaxis in dental procedures should be carried out and more factors should be addressed in research to increase the scope of analysis.
Virtual Design of Novel Coumarinyl-Substituted Sulfonamide Inhibitors of Carbonic Anhydrase II as Potential Drugs against Glaucoma
Authors: Ziki Eric , Akonan Ludovic , Kouman Koffi Charles , Dali Brice , Megnassan Eugene , Kakou-Yao Rita , Tenon Abodou Jules , Frecer Vladimir , Miertus Stanislav 
Published: September 2023

Background: We have carried out virtual design of coumarinyl-substituted sulfonamides (CSAM) analogs as inhibitors of human carbonic anhydrase II (hCA II) endowed with favorable predicted pharmacokinetic profiles and potential therapeutic effects against glaucoma.
Methods: modifying in situ the x-ray structure of 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoyl-phenyl)-acetamide (CSAM0)-hCA II complex (PDB entry 3ML2), permitted 3D models of hCA II-CSAMx complexes preparation for a TS of 14 CSAMs the experimental activities of which are available in the literature (IC50exp). Active bound conformation of the CSAM1-14 assessment led to linear correlation between computed enthalpy of hCA II-CSAMx complexes formation in gas phase (ΔΔHMM) with the IC50exp. Moreover, considering the solvation and ligand loss of entropy upon binding led to a superior QSAR model where a better linear correlation is established between calculated GFE (ΔΔGcom) and IC50exp. The successive 3D-pharmacophore (PH4) built from CSAMs active conformations helped to virtually screen CSAM populating a sulfonamides scaffolds virtual combinatorial library (VCL), focused by Lipinski’s rule-of-five to reach novel CSAMs.
Results: Enthalpy QSAR model: pIC50exp = -0.068×ΔΔHMM + 7.722, R2 = 0.82; GFE QSAR model: pIC50exp = - 0.061× ΔΔGcom + 7.647, R2 = 0.92 and PH4 model: pIC50exp = 1.095×pIC50pre – 0.680, R2 = 0.87. The VCL of more than 1,500,625 CSAMs was lowered to 865,670 drug likely compounds by the Lipinski’s rule (except the restriction Mw ≤ 500 g/mol). The three-point PH4-based screening identified 81 novel CSAMs with predicted IC50pre reaching 78-times better than CSAM1 potency (IC50exp = 23 nM). Computed pharmacokinetic profile of the new candidates showed enhanced cell membrane permeability and high human oral absorption compared to current anti-glaucoma agents.
Conclusions: Combination of QSAR models of the CSAMs’ affinity to the hCA II, pharmacophore model, and ADME profile guided to the sulfonamides inhibitors identification and helped to in silico screen VCL sulfonamides scaffold bearing analogs and allowed emerging of novel more potent compounds with predicted IC50 and favorable pharmacokinetic profiles.
Hot on RAD51C: structure and functions of RAD51C‐XRCC3
Authors: Szakal Barnabas , Branzei Dana 
Published: September 2023

A new study by Longo, Roy et al. has solved the structure of the RAD51C‐XRCC3 (CX3) heterodimer with a bound ATP analog, identifying two main structural interfaces and defining separable replication fork stability roles. One function relates to the ability of RAD51C to bind and assemble CX3 on nascent DNA, with an impact on the ability of forks to restart upon replication stress. The other relates to effective CX3 heterodimer formation, required for 5′ RAD51 filament capping, with effects on RAD51 filament disassembly, fork protection and influencing the persistence of reversed forks.
Novelty detection for election fraud: A case study with agent‐based simulation data
Authors: Yamin Khurram , Jadali Nima , Xie Yao , Nazzal Dima 
Published: September 2023

AbstractIn this paper, we propose a robust election simulation model and independently developed election anomaly detection algorithm that demonstrates the simulation's utility. The simulation generates artificial elections with similar properties and trends as elections from the real world, while giving users control and knowledge over all the important components of the elections. We generate a clean election results dataset without fraud as well as datasets with varying degrees of fraud. We then measure how well the algorithm is able to successfully detect the level of fraud present. The algorithm determines how similar actual election results are as compared to the predicted results from polling and a regression model of other regions that have similar demographics. We use k‐means to partition electoral regions into clusters such that demographic homogeneity is maximized among clusters. We then use a novelty detection algorithm implemented as a one‐class support vector machine where the clean data is provided in the form of polling predictions and regression predictions. The regression predictions are built from the actual data in such a way that the data supervises itself. We show both the effectiveness of the simulation technique and the machine learning model in its success in identifying fraudulent regions.
Dosimetric evaluation of a spinal cord dose‐limiting 3D‐CRT technique for radiotherapy of spinal metastases
Authors: Arnold Christian Cornelius , Toussaint André , Mantel Frederick , Flentje Michael , Bratengeier Klaus 
Published: September 2023

AbstractBackgroundTo evaluate the possible advantages of a simple spinal cord (SC) dose‐limiting three‐dimensional conformal radiotherapy (3D‐CRT) technique in comparison to conventional two‐dimensional (2D) techniques and other 3D‐CRT techniques for spinal bone irradiation.MethodsFor 41 spinal target volumes, seven different techniques were evaluated, using a standard schedule of 30 Gy in 10 fractions. The SC dose‐limiting 3D‐CRT technique 1F2S‐18MV using a single posterior field (F) supplemented by two anterior segment fields (S) and 18‐MV photon beams was compared to two conventional 2D techniques (a single posterior field, PA, and two opposed anterior‐posterior fields, APPA), three other 3D‐CRT techniques (a single posterior field supplemented by four segment fields, 1F4S; two wedged fields, WD, and the SC dose‐limiting variant using 6 MV, 1F2S‐6MV) along with the original clinically applied plans.Results1F2S‐18MV demonstrated notably better results for all target volume parameters compared to the conventional 2D techniques (p < 0.001). Limitation of the SC dose was significantly superior with 1F2S‐18MV in comparison to PA and APPA (SC Dmean: 28.9 ± 0.4 vs. 30.1 ± 0.6 Gy and 30.1 ± 0.4 Gy; SC Dmax: 30.9 ± 0.7 vs. 32.5 ± 1.0 Gy and 31.8 ± 0.7 Gy; SC D1cm3: 30.1 ± 0.6 vs. 31.7 ± 0.9 Gy and 31.1 ± 0.6 Gy; p < 0.001). Likewise, lower mean SC doses with 1F2S‐18MV were observed in comparison to the more treatment time‐consuming 3D‐CRT techniques (1F4S, WD) and the original plans without relevant compromises on the dose homogeneity in the target volume and the dose exposure to the other OARs.ConclusionIn treatment planning of spinal metastases, simple variants of 3D‐CRT‐techniques like 1F2S‐18MV can offer a significant dose limitation to the SC while providing a sufficient dose coverage of the target volume. Especially in patients with favorable life expectancy and potential need for re‐irradiation, such SC dose‐limiting 3D‐CRT techniques may be a reasonable approach.
In Situ Regeneration of Oxidized Copper Flakes Forming Nanosatellite Particles for Non‐Oxidized Highly Conductive Copper Nanocomposites
Authors: Faseela K. P. , Ajmal C. Muhammed , Cha Seokjae , Baik Seunghyun 
Published: September 2023

AbstractCopper (Cu) is an attractive low‐cost alternative to silver or gold. However, it is susceptible to oxidation in air. Here, facile in situ regeneration of oxidized Cu flakes (CuFLs) for the synthesis of highly conductive non‐oxidized nanocomposites is reported. The oxidized CuFLs are regenerated into non‐oxidized CuFLs and Cu nanosatellite (CuNS) particles by formic acid‐aided in situ etching and reduction reaction in soft epoxy matrix. The average particle size of CuNS particles is only 3.3 nm with an interparticle distance of 2.7 nm. Furthermore, the negligible potential barrier height between Cu and epoxy dramatically increases the electrical conductivity (66 893 S cm−1) of the nanocomposite (Cu = 46 vol%) by more than three orders of magnitude. The thermal conductivity is also highest (85.1 W m−1 K−1), compared with Cu‐based nanocomposites in literature. The conductivities are invariant in air for more than 95 days. The simple scalable in situ regeneration of oxidized CuFLs may find immediate industrial applications.
Ion Clusters‐Driven Strong and Acid/Alkali/ Freezing‐Tolerant Conductive Hydrogels for Flexible Sensors in Extreme Environments
Authors: Lyu Yang , Guo Rui , Lin Zhengwei , Zhai Fei , Wu Tao , Jiang Pan , Ji Zhongying , Ma Shuanhong , Shi Xinyan , Wang Xiaolong 
Published: September 2023

AbstractSupramolecular polymer hydrogels, exhibiting wide applications in flexible sensing, wearable electronics, artificial skin, etc., often require complex molecule and component design to adapt extreme environments. Most supramolecular polymer hydrogels currently, however, are unable to satisfy the harsh demands ascribed to their poor mechanical properties and chemical stability. Herein, this study demonstrates a novel strategy to fabricate superstrong polyvinyl alcohol (PVA) hydrogels with densely supramolecular polymer networks (SPNs) and complexation, induced by simple deprotonation and reconfiguration of ion clusters (ICs). Such strategy enables the PVA hydrogels with high strength (9.64 ± 0.5 MPa), compressibility, and recoverability (load objects over ≈10000 times more than its weight), resistance to various solvents, freezing tolerance (keep flexible and conductive even at −50 °C) and many other performances. Notably, the properties of resultant hydrogels surpass majority reported, tackling a long‐standing dilemma both mechanical properties and stability for PVA hydrogels. A proof‐of‐concept spider robot is assembled by 3D printed model, which achieves successfully signal acquisition in different extreme conditions. In this study the multifunctional PVA hydrogels are envisioned as a simple and universal strategy for sensors in various conditions, which is significant for the exploration in extreme environments that are not easily accessible to humans, such as the North and South Poles and solvent leakage area.