bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analytical Method for Determining N-Nitrosodimethylamine and N-Nitrosodiethylamine Contamination in Irbesartan, Olmesartan and Metformin by UPLC-APCI-MS/MS in Tablet Dosage Form
Authors: Deeb Ahmad A , Hailat Mohammad , Aldoqum Hani M , Abuothman Mohammad , Abuyaman Omar , Abu Dayyih Wael 
Published: August 2023

Abstract
N-nitrosamine pollutants are probable carcinogens. Regulatory agencies declared their presence in the drugs unsafe for human consumption and demanded their recall. Using ultra-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (UPLC-APCI-MS/MS) in tablet dosage form based on International Conference on Harmonization (ICH) tripartite guideline criteria, we aim to develop and test a new approach for identifying and validating nitrosamine-contaminants, N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) in irbesartan, olmesartan and metformin. The column was Phenomenex Luna-C18, 100 × 3.0 mm and 3.0 μm. A mobile gradient phase of formic acid in either water or methanol separated the impurities. NDMA and NDEA had retention times of 0.85 and 2.55 min, respectively. The detector’s linearity was established at concentrations ranging from 0.6 to 100 ng/mL. R2 for NDMA and NDEA were 0.9996 and 0.9998, respectively, with a linear response function established at 0.6–100 ng/mL. Limit of detection and limit of quantification for NDMA and NDEA were 0.35, 0.29 and 0.55, 0.37 ng/mL, respectively. On average, recovery rates for NDMA and NDEA ranged from 96.0 to 98.4 and 96.2 to 98.0%, respectively. The relative standard deviation for NDMA and NDEA was 3.46 and 2.69, respectively. According to the ICH guidelines, the developed method was quick, sensitive and valid. The pharmaceutical formulations of irbesartan, olmesartan and metformin may be regularly examined using the approach provided here.
Are the effects of catch-and-release angling evident in changes to mRNA abundances related to metabolism, acid–base regulation and stress in lake trout (Salvelinus namaycush) gills?
Authors: DePasquale Simon W , Howell Bradley E , Navarroli Giulio , Jeffries Kenneth M , Cooke Steven J , Wijenayake Sanoji , Jeffrey Jennifer D , Hasler Caleb T 
Published: August 2023

Abstract
Catch-and-release (C&R) angling is a conservation-oriented practice intended to reduce the impact recreational angling has on fish populations. Even though most recreationally angled fish are released, little is known about how C&R angling impacts fish at the cellular or tissue level. As the first to explore the impacts of C&R angling on mRNA abundances, our study aimed to identify how the stress of angling influenced metabolism, acid–base regulation and cellular stress in the gills of lake trout (Salvelinus namaycush). Because gills are responsible for metabolic gas exchange, are crucial sites of acid–base homeostasis and respond to stressors quickly, we hypothesized that the relative mRNA abundance of genes related to these three physiological processes would be altered after angling. We took gill samples of live lake trout at 0, 2 or 48 h after fish were angled by rod and reel, and then used quantitative PCR (qPCR) to measure the relative abundance of nine candidate mRNA transcripts. Heat shock protein 70 (hsp70) mRNA levels significantly increased over 5-fold 2 h after angling, indicating a potential activation of a cytoprotective response. However, contrary to our hypothesis, we observed no change in the relative mRNA abundance of genes related to metabolism or acid–base regulation in response to C&R angling within a 48-h period. As C&R angling can negatively impact fish populations, further use of transcript-level studies will allow us to understand the impact C&R has on specific tissues and improve our knowledge of how C&R influences overall fish health.
‘So Manly and Ornamental’: Shoe Buckles and Britain’s Eighteenth Century
Authors: McCormack Matthew 
Published: August 2023

Abstract
The shoe buckle of the eighteenth century is an alien object today. At the time, shoes were manufactured without fastenings and the buckle was purchased separately. This offered opportunities for decoration, particularly for men, whose shoes were otherwise plain and unchanging. Over the course of the century, buckles grew larger and more elaborate, reaching their apogee in the ‘Artois’ style of the 1780s. In the wake of the French Revolution, buckles came to be associated with effeminacy and the excesses of the aristocracy, so fell from fashion. This article explores the roles of gender and class in this story, and will challenge the usual association of the buckle with foppery, demonstrating that they were consistent with mainstream masculinities until the 1790s. In order to understand the shoe buckle’s significance, the article engages with it as a material artefact. With their intricate mechanisms, complex processes of fastening, and roles in meaningful rituals, shoe buckles give us an insight into haptic practices and the embodiment of gender. The article therefore makes the case that shoe buckles were characteristic of masculinities, material practices and social identities in eighteenth-century Britain.
What Is Islamic History? Muslims, Non-Muslims and the History of Everyone Else
Authors: Sahner Christian C 
Published: August 2023

Abstract
This is a work of historical criticism, not a research article or a book review. It re-examines what we mean by ‘Islamic’ when we speak about the discipline of ‘Islamic history’, the standard term for the history of the lands where Muslims were politically and, in some senses, culturally dominant, especially during the Middle Ages. It investigates the consequences of this implicitly religious label for who is included in the grand narrative (Muslims, chiefly Sunnīs) and who is not (non-Muslims and Muslim minorities). It then proposes an alternative approach that favours geography and political periodisation as ways of organising how we think about the past in a more neutral fashion.
Congenital hypogonadotropic hypogonadism in a patient with a de novoPOGZmutation
Authors: Eskici Nazli , Madhusudan Shrinidhi , Vaaralahti Kirsi , Yellapragada Venkatram , Gomez-Sanchez Celia , Kärkinen Juho , Almusa Henrikki , Brandstack Nina , Miettinen Päivi J , Wang Yafei , Raivio Taneli 
Published: August 2023

AbstractObjectiveCongenital hypogonadotropic hypogonadism (CHH) is a rare, genetically heterogeneous reproductive disorder caused by gonadotropin-releasing hormone (GnRH) deficiency. Approximately half of CHH patients also have decreased or absent sense of smell, that is, Kallmann syndrome (KS). We describe a patient with White–Sutton syndrome (developmental delay and autism spectrum disorder) and KS due to a heterozygous de novo mutation in POGZ (c.2857C&gt;T, p.(Gln953*)), a gene encoding pogo transposable element derived with zinc finger domain, which acts as a transcriptomic regulator of neuronal networks.Design and MethodsWe modeled the role of POGZ in CHH by generating 2 clonal human pluripotent stem cell lines with CRISPR/Cas9, carrying either the heterozygous patient mutation (H11 line) or a homozygous mutation (c.2803-2906del; p.E935Kfs*7 encoding a truncated POGZ protein; F6del line).ResultsDuring the differentiation to GnRH neurons, neural progenitors derived from F6del line displayed severe proliferation defect, delayed wound-healing capacity, downregulation of intermediate progenitor neuron genes TBR1 and TBR2, and immature neuron markers PAX6 and TUBB3 and gave rise to fewer neurons with shorter neurites and less neurite branch points compared to the WT and H11 lines (P &lt; .005). Both lines, however, could be successfully differentiated to GnRH neurons.ConclusionsIn conclusion, this is the first report on the overlap between White–Sutton syndrome and CHH. POGZ mutations do not hinder GnRH neuron formation but may cause CHH/KS by affecting the size and motility of the anterior neural progenitor pool and neurite outgrowth.
Judicial Independence and Impartiality: Tenure Changes at the European Court of Human Rights
Authors: Molbæk-Steensig Helga , Quemy Alexandre 
Published: August 2023

Abstract
Judges should be impartial and independent, judging based solely on the law. Current constitutional literature suggests an important factor in securing this may be the length of tenure. The assumption is that judges with non-renewable terms are more independent than judges with renewable terms since they do not have to worry about reappointment, but proving this assumption empirically is not straightforward. Obstacles include difficulties in comparing different courts and the fact that there is often no obvious case outcome that proves independence. This article aims to overcome these obstacles with a mixed-methods study on the European Court of Human Rights during a time when the tenure rules changed. The study goes beyond the counting of votes and analyses the arguments used in separate opinions as indicators of independence. Our main findings are that, after the introduction of non-renewable terms, judges write more opinions overall, and more of them criticize the judges’ appointing states, while fewer defend it. We also find that judges on non-renewable terms are on average more likely to write opinions addressing violations as systemic problems and to use their opinions to provide guidance for their appointing states on implementing judgments and improving human rights protection.
Renal function and decongestion with acetazolamide in acute decompensated heart failure: the ADVOR trial
Authors: Meekers Evelyne , Dauw Jeroen , Martens Pieter , Dhont Sebastiaan , Verbrugge Frederik H , Nijst Petra , ter Maaten Jozine M , Damman Kevin , Mebazaa Alexandre , Filippatos Gerasimos , Ruschitzka Frank , Tang Wai Hong Wilson , Dupont Matthias , Mullens Wilfried 
Published: August 2023

Abstract

Background and Aims
In the ADVOR trial, acetazolamide improved decongestion in acute decompensated heart failure (ADHF). Whether the beneficial effects of acetazolamide are consistent across the entire range of renal function remains unclear.

Methods
This is a pre-specified analysis of the ADVOR trial that randomized 519 patients with ADHF to intravenous acetazolamide or matching placebo on top of intravenous loop diuretics. The main endpoints of decongestion, diuresis, natriuresis, and clinical outcomes are assessed according to baseline renal function. Changes in renal function are evaluated between treatment arms.

Results
On admission, median estimated glomerular filtration rate (eGFR) was 40 (30–52) mL/min/1.73 m². Acetazolamide consistently increased the likelihood of decongestion across the entire spectrum of eGFR (P-interaction = .977). Overall, natriuresis and diuresis were higher with acetazolamide, with a higher treatment effect for patients with low eGFR (both P-interaction &lt; .007). Acetazolamide was associated with a higher incidence of worsening renal function (WRF; rise in creatinine ≥ 0.3 mg/dL) during the treatment period (40.5% vs. 18.9%; P &lt; .001), but there was no difference in creatinine after 3 months (P = .565). This was not associated with a higher incidence of heart failure hospitalizations and mortality (P-interaction = .467). However, decongestion at discharge was associated with a lower incidence of adverse clinical outcomes irrespective of the onset of WRF (P-interaction = .805).

Conclusions
Acetazolamide is associated with a higher rate of successful decongestion across the entire range of renal function with more pronounced effects regarding natriuresis and diuresis in patients with a lower eGFR. While WRF occurred more frequently with acetazolamide, this was not associated with adverse clinical outcomes.

ClinicalTrials.gov Identifier
NCT03505788.
Vulnerability to environmental and climatic health provocations among women and men hospitalized with chronic heart disease: insights from the RESILIENCE TRIAL cohort
Authors: Stewart Simon , Patel Sheila K , Lancefield Terase F , Rodrigues Thalys S , Doumtsis Nicholas , Jess Ashleigh , Vaughan-Fowler Emily-Rose , Chan Yih-Kai , Ramchand Jay , Yates Paul A , Kwong Jason C , McDonald Christine F , Burrell Louise M 
Published: August 2023

Abstract

Aims
We aimed to recruit a representative cohort of women and men with multi-morbid chronic heart disease as part of a trial testing an innovative, nurse-co-ordinated, multi-faceted intervention to lower rehospitalization and death by addressing areas of vulnerability to external challenges to their health.

Methods and results
The prospective, randomized open, blinded end-point RESILIENCE Trial recruited 203 hospital inpatients (mean age 75.7 ± 10.2 years) of whom 51% were women and 94% had combined coronary artery disease, heart failure, and/or atrial fibrillation. Levels of concurrent multi-morbidity were high (mean Charlson Index of Comorbidity Score 6.5 ± 2.7), and 8.9% had at least mild frailty according to the Rockwood Clinical Frailty Scale. Including the index admission, 19–20% of women and men had a pre-existing pattern of seasonally linked hospitalization (seasonality). Detailed phenotyping revealed that 48% of women and 40% of men had ≥3 physiological factors, and 15% of women and 16% of men had ≥3 behavioural factors likely to increase their vulnerability to external provocations to their health. Overall, 61–62% of women and men had ≥4 combined factors indicative of such vulnerability. Additional factors such as reliance on the public health system (63 vs. 49%), lower education (30 vs. 14%), and living alone (48 vs. 29%) were more prevalent in women.

Conclusion
We successfully recruited women and men with multi-morbid chronic heart disease and bio-behavioural indicators of vulnerability to external provocations to their health. Once completed, the RESILIENCE TRIAL will provide important insights on the impact of addressing such vulnerability (promoting resilience) on subsequent health outcomes.

Registration
ClinicalTrials.org: NCT04614428.
Whole genome sequence of the deep-sea sponge Geodia barretti (Metazoa, Porifera, Demospongiae)
Authors: Steffen Karin , Proux-Wéra Estelle , Soler Lucile , Churcher Allison , Sundh John , Cárdenas Paco 
Published: August 2023

Abstract
Sponges are among the earliest branching extant animals. As such, genetic data from this group are valuable for understanding the evolution of various traits and processes in other animals. However, like many marine organisms, they are notoriously difficult to sequence, and hence, genomic data are scarce. Here, we present the draft genome assembly for the North Atlantic deep-sea high microbial abundance species Geodia barretti Bowerbank 1858, from a single individual collected on the West Coast of Sweden. The nuclear genome assembly has 4,535 scaffolds, an N50 of 48,447 bp and a total length of 144 Mb; the mitochondrial genome is 17,996 bp long. BUSCO completeness was 71.5%. The genome was annotated using a combination of ab initio and evidence-based methods finding 31,884 protein-coding genes.
Comparison of genomic-enabled cross selection criteria for the improvement of inbred line breeding populations
Authors: Danguy des Déserts Alice , Durand Nicolas , Servin Bertrand , Goudemand-Dugué Ellen , Alliot Jean-Marc , Ruiz Daniel , Charmet Gilles , Elsen Jean-Michel , Bouchet Sophie 
Published: August 2023

Abstract
A crucial step in inbred plant breeding is the choice of mating design to derive high-performing inbred varieties while also maintaining a competitive breeding population to secure sufficient genetic gain in future generations. In practice, the mating design usually relies on crosses involving the best parental inbred lines to ensure high mean progeny performance. This excludes crosses involving lower performing but more complementary parents in terms of favorable alleles. We predicted the ability of crosses to produce putative outstanding progenies (high mean and high variance progeny distribution) using genomic prediction models. This study compared the benefits and drawbacks of 7 genomic cross selection criteria (CSC) in terms of genetic gain for 1 trait and genetic diversity in the next generation. Six CSC were already published, and we propose an improved CSC that can estimate the proportion of progeny above a threshold defined for the whole mating plan. We simulated mating designs optimized using different CSC. The 835 elite parents came from a real breeding program and were evaluated between 2000 and 2016. We applied constraints on parental contributions and genetic similarities between selected parents according to usual breeder practices. Our results showed that CSC based on progeny variance estimation increased the genetic value of superior progenies by up to 5% in the next generation compared to CSC based on the progeny mean estimation (i.e. parental genetic values) alone. It also increased the genetic gain (up to 4%) and/or maintained more genetic diversity at QTLs (up to 4% more genic variance when the marker effects were perfectly estimated).
Container Profiler: Profiling resource utilization of containerized big data pipelines
Authors: Hoang Varik , Hung Ling-Hong , Perez David , Deng Huazeng , Schooley Raymond , Arumilli Niharika , Yeung Ka Yee , Lloyd Wes 
Published: August 2023

Abstract

Background
This article presents the Container Profiler, a software tool that measures and records the resource usage of any containerized task. Our tool profiles the CPU, memory, disk, and network utilization of containerized tasks collecting over 60 Linux operating system metrics at the virtual machine, container, and process levels. The Container Profiler supports performing time-series profiling at a configurable sampling interval to enable continuous monitoring of the resources consumed by containerized tasks and pipelines.

Results
To investigate the utility of the Container Profiler, we profile the resource utilization requirements of a multistage bioinformatics analytical pipeline (RNA sequencing using unique molecular identifiers). We examine profiling metrics to assess patterns of CPU, disk, and network resource utilization across the different stages of the pipeline. We also quantify the profiling overhead of our Container Profiler tool to assess the impact of profiling a running pipeline with different levels of profiling granularity, verifying that impacts are negligible.

Conclusions
The Container Profiler provides a useful tool that can be used to continuously monitor the resource consumption of long and complex containerized applications that run locally or on the cloud. This can help identify bottlenecks where more resources are needed to improve performance.
All-or-Nothing Behavior and Catastrophic Thinking Predict Fatigue in Inflammatory Bowel Disease: A Prospective Cohort Study
Authors: Moulton Calum D , Jordan Cheryl , Hayee Bu’Hussain , Chalder Trudie 
Published: August 2023

Lay Summary
Patients with inflammatory bowel disease (IBD) often report fatigue. However, the reasons for this are poorly understood. In this study of people with IBD, we demonstrate that all-or-nothing behavior (being very active then needing to resting a while) and catastrophic thinking (making very negative assumptions about outcomes) both predict worsening in fatigue over time.
‘Most of our termes now vsed in warres are deriued from straungers’: Robert Barret’s Glossary of Military Terms inThe Theorike and Practike of Moderne Warres (1598)
Authors: Rodríguez-Álvarez Alicia 
Published: August 2023

Abstract
The first English dictionary of military terms was published anonymously in 1702 under the title AMilitary Dictionary. However, one glossary of this nature had already been attached to Robert Barret’s (Anon. 1702)The Theorike and Practike of Moderne Warres in 1598: ‘A Table, shewing the signification of sundry forraine words, vsed in these discourses’. Barret had fought in many battles in Europe, where English soldiers came into contact with comrades-in-arms from other countries. Hence, Barret’s glossary constitutes a first-hand source of information on the loanwords used in English to refer to technological and strategic novelties on the field of military science at the time. This article (i) provides a first analysis of Barret’s glossary; (ii) confirms that Barret’s professional expertise as a soldier contributed to more complete and informative definitions than the ones in contemporary general dictionaries; (iii) compares the source languages Barret assigned to the entries in his glossary with the source languages specified in contemporary lexicographical works and in the Oxford English Dictionary; and (iv) confirms the relevance of Barret’s glossary as a testimony to the military jargon incorporated into English from different languages during the sixteenth century. Finally, a close comparison of the definitions of the same entries in Barret’s glossary and Florio’s A Worlde of Wordes (1598) has revealed Florio’s indebtedness to Barret’s military glossary.
Impact of a community pharmacy led antibiotic amnesty in the Midlands region of England
Authors: Ercolani Marco G , Aggarwal Rakhi , Barker Angela , Cooper Donna , Jamieson Conor 
Published: August 2023

Abstract

Objectives
Antimicrobial resistance is a recognised threat to human health and may be driven by the unsafe disposal of antibiotics via domestic waste streams, contaminating the environment. A community pharmacy based antibiotic amnesty could address this.

Methods
We evaluated the impact of an antibiotic amnesty promoting the return of unused antibiotics to community pharmacies in the Midlands region of England during World Antibiotic Awareness Week in November 2021.

Results
Two hundred and thirty nine pharmacies participated voluntarily and held amnesty conversations with 7399 people, 369 part used and 126 full packs of antibiotics were returned.

Conclusions
This is an important public health initiative that could be replicated more widely.
A method for the sensitive targeted screening of synthetic cannabinoids and opioids in whole blood by LC–QTOF-MS with simultaneous suspect screening using HighResNPS.com
Authors: Trobbiani Stephen , Stockham Peter , Kostakis Chris 
Published: August 2023

Abstract
A sensitive method for the qualitative screening of synthetic cannabinoids and opioids in whole blood was developed and validated using alkaline liquid–liquid extraction (LLE) and liquid chromatography–time-of-flight mass spectrometry (LC–QTOF-MS). Estimated limits of detection for validated compounds ranged from 0.03 to 0.29 µg/L (median, 0.04 µg/L) for the 27 opioids and from 0.04 to 0.5 µg/L (median, 0.07 µg/L) for the 23 synthetic cannabinoids. Data processing occurred in two stages; first, a targeted screen was performed using an in-house database containing retention times, accurate masses and MS-MS spectra for 79 cannabinoids and 53 opioids. Suspect screening was then performed using a database downloaded from the crowd sourced NPS data website HighResNPS.com which contains mass, consensus MS-MS data and laboratory-specific predicted retention times for a far greater number of compounds. The method was applied to 61 forensic cases where synthetic cannabinoid or opioid screening was requested by the client or their use was suspected due to case information. CUMYL-PEGACLONE was detected in two cases and etodesnitazine, 5 F-MDMB-PICA, 4-cyano-CUMYL-BUTINACA and carfentanil were detected in one case each. These compounds were within the targeted scope of the method but were also detected through the suspect screening workflow. The method forms a solid base for expansion as more compounds emerge onto the illicit drug market.