bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supervised machine learning classification of psychosis biotypes based on brain structure: findings from the Bipolar-Schizophrenia network for intermediate phenotypes (B-SNIP)
Authors: Koen Joshua D. , Lewis Leslie , Rugg Michael D. , Clementz Brett A. , Keshavan Matcheri S. , Pearlson Godfrey D. , Sweeney John A. , Tamminga Carol A. , Ivleva Elena I. 
Published: August 2023

AbstractTraditional diagnostic formulations of psychotic disorders have low correspondence with underlying disease neurobiology. This has led to a growing interest in using brain-based biomarkers to capture biologically-informed psychosis constructs. Building upon our prior work on the B-SNIP Psychosis Biotypes, we aimed to examine whether structural MRI (an independent biomarker not used in the Biotype development) can effectively classify the Biotypes. Whole brain voxel-wise grey matter density (GMD) maps from T1-weighted images were used to train and test (using repeated randomized train/test splits) binary L2-penalized logistic regression models to discriminate psychosis cases (n = 557) from healthy controls (CON, n = 251). A total of six models were evaluated across two psychosis categorization schemes: (i) three Biotypes (B1, B2, B3) and (ii) three DSM diagnoses (schizophrenia (SZ), schizoaffective (SAD) and bipolar (BD) disorders). Above-chance classification accuracies were observed in all Biotype (B1 = 0.70, B2 = 0.65, and B3 = 0.56) and diagnosis (SZ = 0.64, SAD = 0.64, and BD = 0.59) models. However, the only model that showed evidence of specificity was B1, i.e., the model was able to discriminate B1 vs. CON and did not misclassify other psychosis cases (B2 or B3) as B1 at rates above nominal chance. The GMD-based classifier evidence for B1 showed a negative association with an estimate of premorbid general intellectual ability, regardless of group membership, i.e. psychosis or CON. Our findings indicate that, complimentary to clinical diagnoses, the B-SNIP Psychosis Biotypes may offer a promising approach to capture specific aspects of psychosis neurobiology.
Combining a parsimonious mathematical model with infection data from tailor-made experiments to understand environmental transmission
Authors: Gamża Anna M. , Hagenaars Thomas J. , Koene Miriam G. J. , de Jong Mart C. M. 
Published: August 2023

AbstractAlthough most infections are transmitted through the environment, the processes underlying the environmental stage of transmission are still poorly understood for most systems. Improved understanding of the environmental transmission dynamics is important for effective non-pharmaceutical intervention strategies. To study the mechanisms underlying environmental transmission we formulated a parsimonious modelling framework including hypothesised mechanisms of pathogen dispersion and decay. To calibrate and validate the model, we conducted a series of experiments studying distance-dependent transmission of Campylobacter jejuni in broilers. We obtained informative simultaneous estimates for all three model parameters: the parameter of C. jejuni inactivation, the diffusion coefficient describing pathogen dispersion, and the transmission rate parameter. The time and distance dependence of transmission in the fitted model is quantitatively consistent with marked spatiotemporal patterns in the experimental observations. These results, for C. jejuni in broilers, show that the application of our modelling framework to suitable transmission data can provide mechanistic insight in environmental pathogen transmission.
Locational memory of macrovessel vascular cells is transcriptionally imprinted
Authors: Spanjersberg Talitha C. F. , Oosterhoff Loes A. , Kruitwagen Hedwig S. , van den Dungen Noortje A. M. , Vernooij Johannes C. M. , Asselbergs Folkert W. , Mokry Michal , Spee Bart , Harakalova Magdalena , van Steenbeek Frank G. 
Published: August 2023

AbstractVascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells and vascular smooth muscle cells from nine adult canine macrovessels: the aorta, coronary artery, vena cava, portal vein, femoral artery, femoral vein, saphenous vein, pulmonary vein, and pulmonary artery. We observed that organ-specific expression patterns persist in vitro, indicating that these genes are not regulated by blood flow or surrounding cell types but are likely fixed in the epigenetic memory. We further demonstrated the preserved location-specific expression of GATA4 protein in cultured cells and in the primary adult vessel. On a functional level, arterial and venous endothelial cells differed in vascular network morphology as the arterial networks maintained a higher complexity. Our findings prompt the rethinking of the extrapolation of results from single-origin endothelial cell systems.
Adaptive filtering and smoothing algorithm based on variable structure interactive multiple model
Authors: Hu Kai-Yu , Wang Jiaming , Cheng Yuqing , Yang Chunxia 
Published: August 2023

AbstractFor maneuvering target tracking, a novel adaptive variable structure interactive multiple model filtering and smoothing (AVSIMMFS) algorithm is proposed in this paper. Firstly, an accurate model of the variable structure interactive multiple model algorithm is established. Secondly, by constructing a new model subset based on the original model subsets, the matching accuracy between the model subset and the actual maneuvering mode of the target is improved. Then, the AVSIMMFS algorithm is obtained by smoothing the filtered data of the new model subset. Because of the combination of forward filtering and backward smoothing, the target tracking accuracy is further improved. Finally, in order to verify the effectiveness of the algorithm, the simulation is carried out on two cases. The simulation results show that the tracking performance of AVSIMMFS algorithm is better than other methods and has lower calculation cost.
Sex differences in the kinematics and kinetics of the foot and plantar aponeurosis during drop-jump
Authors: Matsumoto Yuka , Ogihara Naomichi , Kosuge Sachiko , Hanawa Hiroki , Kokubun Takanori , Kanemura Naohiko 
Published: August 2023

AbstractPlantar fasciitis is one of the most common musculoskeletal injuries in runners and jumpers, with a higher incidence in females. However, mechanisms underlying sex-associated differences in its incidence remain unclear. This study investigated the possible differences in landing and jumping kinematics and kinetics of the foot between sexes during drop-jump activities. Twenty-six participants, including 13 males and 13 females, performed drop-jumps from a platform onto force plates. Nineteen trials including ten males and nine females were selected for inverse dynamics analysis. The patterns of stretch and tensile force generated by the plantar aponeurosis (PA) were estimated using a multi-segment foot model incorporating the PA. Our results demonstrated that dorsiflexion, angular velocity, and normalized plantarflexion moment of the midtarsal joint right after the heel landed on the floor were significantly larger in females than in males. Consequently, the PA strain rate and tensile stress tended to be larger in females than in males. Such differences in the kinematics and kinetics of the foot and the PA between sexes could potentially lead to a higher prevalence of foot injuries such as plantar fasciitis in females.
FPGA realization of four chaotic interference cases in a terrestrial trajectory model and application in image transmission
Authors: Estudillo-Valdez Miguel-Angel , Adeyemi Vincent-Ademola , Tlelo-Cuautle Esteban , Sandoval-Ibarra Yuma , Nuñez-Perez Jose-Cruz 
Published: August 2023

AbstractThis article presents a technique to integrate two dynamical models, a four-wing spherical chaotic oscillator and the elliptical path described by the planet Earth during its translation movement around the sun. Four application cases are derived from the system by varying the dynamics of the chaotic oscillator and these can be applied in information encryption to transmit RGB and grayscale images modulated by CSK. Consequently, the three main contributions of this work are (1) the emulation of the trajectories of the planet Earth with chaotic interference, (2) the CSK modulation and image encryption in a master-slave synchronization topology, and (3) the CSK demodulation for decryption without loss of information with respect to the original information. The three contributions are based on VHDL code implementation. The results of the synchronization, encryption and decryption technique were verified by means of time series and the encrypted images showed a correlation less than − 0.000142 and − 0.0003439 for RGB and grayscale format, respectively, while the retrieved image shows a complete correlation with the image original. In this work, the co-simulations were performed between MATLAB/Simulink and Vivado, using the VHDL language on two FPGA boards from different manufacturers, namely, Xilinx Artix-7 AC701 and Intel Cyclone IV.
Microplastics in gastrointestinal tracts of gentoo penguin (Pygoscelis papua) chicks on King George Island, Antarctica
Authors: Kim Youmin , Kim Hankyu , Jeong Min-Su , Kim Dowoon , Kim Juyang , Jung Jaehak , Seo Hae-Min , Han Hyun-Jin , Lee Woo-Shin , Choi Chang-Yong 
Published: August 2023

AbstractMicroplastics (< 5 mm) have been found in marine ecosystems worldwide, even in Antarctic ecosystems. In this study, the stomach and upper intestines of 14 dead gentoo penguin (Pygoscelis papua) chicks were collected and screened for microplastics on King George Island, a gateway to Antarctic research and tourism. A total of 378 microplastics were identified by Fourier-transform infrared spectroscopy, with 27.0 ± 25.3 microplastics per individual. The detected number of microplastics did not increase with the mass of penguin chicks, suggesting no permanent accumulation of microplastics. However, the concentration of microplastics was much higher (9.1 ± 10.8 microplastics per individual within the size range 100–5000 μm) than the previously reported concentration in the penguin feces, and a greater number of smaller microplastics were found. Marine debris surveys near the breeding colony found various plastic (79.3%) to be the most frequent type of beached debris, suggesting that local sources of marine plastic waste could have contributed to microplastic contamination of penguin chicks being fed by parents that forage in nearby seas. This finding confirms the presence of microplastics in an Antarctic ecosystem and suggests the need for stronger waste management in Antarctica and a standardized scheme of microplastic monitoring in this once-pristine ecosystem.
Real-time jellyfish classification and detection algorithm based on improved YOLOv4-tiny and improved underwater image enhancement algorithm
Authors: Gao Meijing , Li Shiyu , Wang Kunda , Bai Yang , Ding Yan , Zhang Bozhi , Guan Ning , Wang Ping 
Published: August 2023

AbstractThe outbreak of jellyfish blooms poses a serious threat to human life and marine ecology. Therefore, jellyfish detection techniques have earned great interest. This paper investigates the jellyfish detection and classification algorithm based on optical images and deep learning theory. Firstly, we create a dataset comprising 11,926 images. A MSRCR underwater image enhancement algorithm with fusion is proposed. Finally, an improved YOLOv4-tiny algorithm is proposed by incorporating a CBMA module and optimizing the training method. The results demonstrate that the detection accuracy of the improved algorithm can reach 95.01%, the detection speed is 223FPS, both of which are better than the compared algorithms such as YOLOV4. In summary, our method can accurately and quickly detect jellyfish. The research in this paper lays the foundation for the development of an underwater jellyfish real-time monitoring system.
Realization of a pulsed optically pumped Rb clock with a frequency stability below $$10^{-15}$$
Authors: Gozzelino Michele , Micalizio Salvatore , Calosso Claudio E. , Belfi Jacopo , Sapia Adalberto , Gioia Marina , Levi Filippo 
Published: August 2023

AbstractWe present the frequency stability performances of a vapor cell Rb clock based on the pulsed optically pumping (POP) technique. The clock has been developed in the frame of a collaboration between INRIM and Leonardo SpA, aiming to realize a space-qualified POP frequency standard. The results here reported were obtained with an engineered physics package, specifically designed for space applications, joint to laboratory-grade optics and electronics. The measured frequency stability expressed in terms of Allan deviation is$$1.2\times 10^{-13}$$1.2×10-13at 1s and achieves the value of$$6\times 10^{-16}$$6×10-16for integration times of 40000 s (drift removed). This is, to our knowledge, a record result for a vapor-cell frequency standard. In the paper, we show that in order to get this result, a careful stabilization of microwave and laser pulses is required.
A metacontinuum model for phase gradient metasurfaces
Authors: Palma Giorgio , Iemma Umberto 
Published: August 2023

AbstractAcoustic metamaterials and metasurfaces often present complex geometries and microstructures. The development of models of reduced complexity is fundamental to alleviate the computational cost of their analysis and derivation of optimal designs. The main objective of this paper is the derivation and validation of a metacontinuum model for phase gradient-based metasurfaces. The method is based on the transformation acoustics framework and defines the metasurface in terms of anisotropic inertia and bulk modulus. Thermal and viscous dissipation effects in the metacontinuum are accounted for by introducing a complex-valued speed of sound. The model is implemented in a commercial FEM code, and its predictions are compared with numerical simulations on the original geometry and also using an equivalent boundary impedance approach. The results are examined for an exterior acoustics benchmark and for an in-duct installation in terms of transmission coefficient with the four-pole matrix method. The metacontinuum model gives solid results for the prediction of the acoustic properties of the examined metasurface samples for all the analyzed configurations, as accurate as the equivalent impedance model on which it is based and outperforming it in some circumstances.
A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome
Authors: Ben-Mahmoud Afif , Kishikawa Shotaro , Gupta Vijay , Leach Natalia T. , Shen Yiping , Moldovan Oana , Goel Himanshu , Hopper Bruce , Ranguin Kara , Gruchy Nicolas , Maas Saskia M , Lacassie Yves , Kim Soo-Hyun , Kim Woo-Yang , Quade Bradley J. , Morton Cynthia C. , Kim Cheol-Hee , Layman Lawrence C. , Kim Hyung-Goo 
Published: August 2023

AbstractIn a patient diagnosed with both Kallmann syndrome (KS) and intellectual disability (ID), who carried an apparently balanced translocation t(7;12)(q22;q24)dn, array comparative genomic hybridization (aCGH) disclosed a cryptic heterozygous 4.7 Mb deletion del(12)(p11.21p11.23), unrelated to the translocation breakpoint. This novel discovery prompted us to consider the possibility that the combination of KS and neurological disorder in this patient could be attributed to gene(s) within this specific deletion at 12p11.21-12p11.23, rather than disrupted or dysregulated genes at the translocation breakpoints. To further support this hypothesis, we expanded our study by screening five candidate genes at both breakpoints of the chromosomal translocation in a cohort of 48 KS patients. However, no mutations were found, thus reinforcing our supposition. In order to delve deeper into the characterization of the 12p11.21-12p11.23 region, we enlisted six additional patients with small copy number variations (CNVs) and analyzed eight individuals carrying small CNVs in this region from the DECIPHER database. Our investigation utilized a combination of complementary approaches. Firstly, we conducted a comprehensive phenotypic-genotypic comparison of reported CNV cases. Additionally, we reviewed knockout animal models that exhibit phenotypic similarities to human conditions. Moreover, we analyzed reported variants in candidate genes and explored their association with corresponding phenotypes. Lastly, we examined the interacting genes associated with these phenotypes to gain further insights. As a result, we identified a dozen candidate genes: TSPAN11 as a potential KS candidate gene, TM7SF3, STK38L, ARNTL2, ERGIC2, TMTC1, DENND5B, and ETFBKMT as candidate genes for the neurodevelopmental disorder, and INTS13, REP15, PPFIBP1, and FAR2 as candidate genes for KS with ID. Notably, the high-level expression pattern of these genes in relevant human tissues further supported their candidacy. Based on our findings, we propose that dosage alterations of these candidate genes may contribute to sexual and/or cognitive impairments observed in patients with KS and/or ID. However, the confirmation of their causal roles necessitates further identification of point mutations in these candidate genes through next-generation sequencing.
Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction
Authors: Hayashi Hiroki , Sun Jiao , Yanagida Yuka , Otera Takako , Tai Jiayu A. , Nishikawa Tomoyuki , Yamashita Kunihiko , Sakaguchi Naoki , Yoshida Shota , Baba Satoshi , Chang Chin Yang , Shimamura Munehisa , Okamoto Sachiko , Amaishi Yasunori , Chono Hideto , Mineno Junichi , Rakugi Hiromi , Morishita Ryuichi , Nakagami Hironori 
Published: August 2023

AbstractEmerging SARS-CoV-2 Omicron variants are highly contagious with enhanced immune escape mechanisms against the initially approved COVID-19 vaccines. Therefore, we require stable alternative-platform vaccines that confer protection against newer variants of SARS-CoV-2. We designed an Omicron B.1.1.529 specific DNA vaccine using our DNA vaccine platform and evaluated the humoral and cellular immune responses. SD rats intradermally administered with Omicron-specific DNA vaccine via pyro-drive jet injector (PJI) thrice at 2-week intervals elicited high antibody titers against the Omicron subvariants as well as the ancestral strain. Indeed, the Omicron B.1.1.529-specific antibody titer and neutralizing antibody were higher than that of other strains. Longitudinal monitoring indicated that anti-spike (ancestral and Omicron) antibody titers decreased toward 30 weeks after the first vaccination dose. However, neutralization activity remained unaltered. Germinal center formation was histologically detected in lymph nodes in rats immunized with Omicron DNA vaccine. Ancestral spike-specific immune cell response was slightly weaker than Omicron spike-specific response in splenocytes with Omicron-adapted DNA vaccine, evaluated by ELISpot assay. Collectively, our findings suggest that Omicron targeting DNA vaccines via PJI can elicit robust durable antibody production mediated by germinal center reaction against this new variant as well as partially against the spike protein of other SARS-CoV-2 variants.
Intraoperative use of fibrin glue in blepharoplasty: a possible solution to reduce postoperative complication
Authors: Lee Kangmin , Chang Minwook 
Published: August 2023

AbstractThe purpose of this study was to investigate the effects of intraoperative fibrin glue use on surgery for blepharoptosis. This retrospective study included patients with acquired blepharoptosis who underwent surgical correction and were followed for at least one month. Patients were classified into two groups depending on whether treated with antithrombotic agents or otherwise. All patients taking antithrombotic agents discontinued with the treatment one week prior to surgery in accordance with our clinical guidelines. Preoperative and postoperative marginal reflex distance 1(MRD1) and ecchymosis grade were evaluated and compared. The subjects were 56 patients (111 eyes) who discontinued antithrombotic agents before surgery and 59 patients (117 eyes) who had never taken antithrombotic agents. Fibrin glue was used in 13 patients (26 eyes, 23.4%) in the antithrombotic group, and 11 patients (21 eyes, 17.9%) in the non-antithrombotic group. The rate of severe ecchymosis was significantly lower in patients who used fibrin glue in the antithrombotic group at 1 week (11.5 vs 40.0%, p = 0.008). However, in non-antithrombotic group, there was no difference in the rate of severe ecchymosis according to the use of fibrin glue at 1 week (14.3 vs 30.2%, p = 0.181). In patients with a history of taking antithrombotic agents, the intraoperative use of fibrin glue is thought to be helpful as it could significantly reduce significant ecchymosis.
Reference intervals and sources of variation of pressure pain threshold for quantitative sensory testing in a Japanese population
Authors: Suzuki Hidenori , Tahara Shu , Mitsuda Mao , Funaba Masahiro , Fujimoto Kazuhiro , Ikeda Hiroaki , Izumi Hironori , Yukata Kiminori , Seki Kazushige , Uranami Kota , Ichihara Kiyoshi , Nishida Norihiro , Sakai Takashi 
Published: August 2023

AbstractQuantitative sensory testing (QST) is useful when analysing musculoskeletal pain disorders. A handheld algometer is most commonly used for pressure pain threshold (PPT) tests. However, reference intervals for PPTs are not elucidated. We assessed reference intervals of PPTs for QST in 158 healthy adult Japanese with no history of musculoskeletal or neurological problems. A handheld algometer was used to record PPT at five different assessment sites on the body: lumbar paravertebral muscle, musculus gluteus maximus, quadriceps, tibialis anterior muscle, and anterior talofibular ligament. Multiple regression analysis was performed to explore sources of variation of PPT according to sex, age, body mass index, UCLA Activity Level Rating, and Tegner Activity Score. Reference intervals were determined parametrically by Gaussian transformation of PPT values using the two-parameter Box-Cox formula. Results of multiple regression analysis revealed that age was significantly associated with PPT of lumbar paravertebral muscle and musculus gluteus maximus. In females, body mass index showed significant positive correlation with PPT of anterior talofibular ligament, and UCLA Activity Level Rating also showed significant positive association with tibialis anterior muscle and anterior talofibular ligament. Site-specific reference intervals of PPTs for Japanese are of practical relevance in fields of pain research using a handheld algometer.