bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre anhelos e imposiciones
Authors: Cadavid Valderrama César Augusto , García Gómez María Cristina , Londoño Tabares Rosa María , Santos Mosquera Anyi Melissa 
Published: May 2023

El cuerpo femenino se ha visto permeado por diferentes ideas y discursos que han designado cómo debe ser y verse; llevando incluso a que se le destinen modelos para moverse, expresarse y comportarse. En la actualidad, el cuerpo femenino es atravesado por la influencia y la normativa de los medios de comunicación, la familia, la sociedad, la cultura, la economía, la política, y el contexto educativo no debe desconocerlo. Por esto, resulta necesario fijarse en la manera en que dichos discursos se disponen en lo educativo, llevando a un interés por conocer la interpretación de las estudiantes sobre aquello que dicen de ellas o que refieren de sus compañeras, de acuerdo con las relaciones interpersonales que establecen y como éstas en ocasiones se ven influenciadas por discursos socioculturales enfocados en el hombre y en una idea mercantil de la belleza. Lo anterior permite interrogarse como sociedad respecto a la forma en la que se han venido transmitiendo prototipos de belleza, de cuerpo femenino y diferentes modelos de movimiento, comportamiento y expresión con los que éste debe cumplir e incluso sobre aquellas atribuciones que se le han asignado como delicadeza, ternura, y sumisión; ya que estas expresiones e ideales afectan la autopercepción, la autoestima y la relación que las mujeres tienen con su propio cuerpo, y en ciertos casos no concuerda con los deseos, las aspiraciones y las posibilidades reales de las mujeres. Para esta investigación se tuvo como objetivo principal describir las percepciones que tienen del cuerpo femenino las estudiantes del grado 9 de la Institución Educativa La Piedad y sus afectaciones en el acto educativo para el año académico 2021, en la ciudad de Medellín; dejando como resultado la descripción de sentimientos de intimidación en las estudiantes por miradas y comentarios relacionados con la forma en cómo se arreglan, se comportan o se maquillan, observándose así discursos estereotipados sobre la feminidad.
Tele rehabilitación con el uso de Triburter en un paciente post Covid-19
Authors: Rincón Castillo Emerson Julian 
Published: May 2023

Se presenta el caso de un hombre de 45 años con diagnóstico de Covid-19, de dos semanas de evolución, con síntomas de disnea, depresión, disminución significativa de la capacidad funcional y de su calidad de vida. El paciente realizó 10 sesiones de tele rehabilitación, las cuales incluyeron ejercicios para el entrenamiento y fortalecimiento de los músculos ventilatorios, así como ejercicios de miembros superiores e inferiores para mejorar la capacidad funcional del paciente. Así mismo, en la intervención de incluyo como dispositivo clave el uso del Triburter. En el proceso de tele-rehabilitación, se evaluó tanto al inicio como al final la capacidad funcional y síntomas depresivos mediante los instrumentos como el índice de Katz y el PQH9. Al finalizar el proceso de tele rehabilitación el paciente mostró resultados positivos en cuanto a la disminución significativa de los síntomas respiratorios y depresivos, aumento en la capacidad funcional y de la calidad de vida. Se recomienda la tele-rehabilitación como método para intervenir en las secuelas respiratorias, al igual que el uso del Triburter como dispositivo portátil de terapia respiratoria tanto autóloga como dirigida, el cual puede contribuir al desarrollo de un proceso de rehabilitación integral y de calidad en post pandemia.
Esquemas Maladaptativos Tempranos y su Incidencia en los Trastornos de la Conducta Alimentaria: Una Revisión Sistemática
Authors: Castañeda Quirama Leidy - Tatiana 
Published: May 2023

Antecedentes: Los Trastornos de la conducta Alimentaria (TCA) tienen un origen multietiológico y las investigaciones recientes han mostrado un interés creciente en evaluar el rol de los esquemas maladaptativos tempranos (EMTS) en el inicio y mantenimiento de este tipo de patologías, sin embargo, son pocos las investigaciones de corte empírico analítico que aclaren esta relación. La presente revisión sistemática examina el estado actual del conocimiento sobre la incidencia que tienen los esquemas tempranos en los TCA en población clínica y no clínica.
Método: Revisión sistemática de literatura en las bases de datos: Scopus, PubMed y Psychology and Behavioral Sciences Collection
Resultados: Se identificaron 14 estudios para su inclusión. Se encontró que los esquemas de vergüenza/ defectuosidad, deprivación emocional, aislamiento social, inhibición emocional y perfeccionismo, son más prevalentes en población clínica con un TCA, en comparación con población normal.
Conclusión: Los dominios esquemáticos de desconexión y rechazo y de sobrevigilancia e inhibición, podrían convertirse en predictores para el desarrollo y mantenimiento de un trastorno de la conducta alimentaria. Es importante que investigaciones futuras continúen aclarando la relación causal que podría existir entre los EMTS y los TCA, debido a las implicaciones para la conceptualización clínica y la intervención.
Identification of lung adenocarcinoma subtypes and predictive signature for prognosis, immune features, and immunotherapy based on immune checkpoint genes
Authors: Hua Linbin , Wu Jiyue , Ge Jiashu , Li Xin , You Bin , Wang Wei , Hu Bin 
Published: May 2023

Background: Lung adenocarcinoma (LUAD) is the most common variant of non–small cell lung cancer (NSCLC) across the world. Recently, the rapid development of immunotherapy has brought a new dawn for LUAD patients. Closely related to the tumor immune microenvironment and immune cell functions, more and more new immune checkpoints have been discovered, and various cancer treatment studies targeting these novel immune checkpoints are currently in full swing. However, studies on the phenotype and clinical significance of novel immune checkpoints in LUAD are still limited, and only a minority of patients with LUAD can benefit from immunotherapy.Methods: The LUAD datasets were downloaded from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases, and the immune checkpoints score of each sample were calculated based on the expression of the 82 immune checkpoints-related genes (ICGs). The weighted gene co-expression network analysis (WGCNA) was used to obtain the gene modules closely related to the score and two different LUAD clusters were identified based on these module genes by the Non-negative Matrix Factorization (NMF) Algorithm. The differentially expressed genes between the two clusters were further used to construct a predictive signature for prognosis, immune features, and the response to immunotherapy for LUAD patients through a series of regression analyses.Results: A new immune checkpoints-related signature was finally established according to the expression of 7 genes (FCER2, CD200R1, RHOV, TNNT2, WT1, AHSG, and KRTAP5-8). This signature can stratify patients into high-risk and low-risk groups with different survival outcomes and sensitivity to immunotherapy, and the signature has been well validated in different clinical subgroups and validation cohorts.Conclusion: We constructed a novel immune checkpoints-related LUAD risk assessment system, which has a good predictive ability and significance for guiding immunotherapy. We believe that these findings will not only aid in the clinical management of LUAD patients but also provide some insights into screening appropriate patients for immunotherapy.
Effective therapy with Bismuth-212 labeled macroaggregated albumin in orthotopic mouse breast tumor models
Authors: Kauffman Nathan , Singh Satyendra Kumar , Morrison James , Zinn Kurt R. 
Published: May 2023

Intravascularly administered radiation therapy using beta (β-)-emitting radioisotopes has relied on either intravenously injected radiolabeled peptides that target cancer or radiolabeled microspheres that are trapped in the tumor following intra-arterial delivery. More recently, targeted intravenous radiopeptide therapies have explored the use of alpha (α)-particle emitting radioisotopes, but microspheres radiolabeled with α-particle emitters have not yet been studied. Here, FDA-approved macroaggregated albumin (MAA) particles were radiolabeled with Bismuth-212 (Bi-212-MAA) and evaluated using clonogenic and survival assays in vitro and using immune-competent mouse models of breast cancer. The in vivo biodistribution of Bi-212-MAA was investigated in Balb/c and C57BL/6 mice with 4T1 and EO771 orthotopic breast tumors, respectively. The same orthotopic breast cancer models were used to evaluate the treatment efficacy of Bi-212-MAA. Our results showed that macroaggregated albumin can be stably radiolabeled with Bi-212 and that Bi-212-MAA can deliver significant radiation therapy to reduce the growth and clonogenic potential of 4T1 and EO771 cells in vitro. Additionally, Bi-212-MAA treatment upregulated γH2AX and cleaved Caspase-3 expression in 4T1 cells. Biodistribution analyses showed 87–93% of the Bi-212-MAA remained in 4T1 and EO771 tumors 2 and 4 h after injection. Following single-tumor treatments with Bi-212-MAA there was a significant reduction in the growth of both 4T1 and EO771 breast tumors over the 18-day monitoring period. Overall, these findings showed that Bi-212-MAA was stably radiolabeled and inhibited breast cancer growth. Bi-212-MAA is an exciting platform to study α-particle therapy and will be easily translatable to larger animal models and human clinical trials.
Serving families who face economic and related adversities: the ‘5 As’ of effective ECEC service delivery
Authors: Skattebol Jennifer , Adamson Elizabeth , Blaxland Megan 
Published: May 2023

IntroductionFamilies with young children who face economic and related adversities are the most likely group to miss out on the advantages of regular sustained participation in high quality early childhood education and care. In Australia, there are an estimated 11% of children assessed by teachers to have two or more developmental vulnerabilities and many of these children are living in economically disadvantaged contexts. Government policy in Australia aspires to provide universal access to Early Childhood Education and Care (ECEC) services to support children’s outcomes and ensure workforce participation, but policy falls short of ensuring all families can take up high quality early childhood education and care. Government responses to the Covid crisis saw significant changes to the ECEC policy and funding mechanisms. It is timely therefore to reflect on the level of ‘competence’ in the Australian ECEC systems. Coined this term to refer to a system that is sustainable, inclusive, and effective for all families.MethodsUsing a Delphi methodology, we coalesced the insights of high-level stakeholders who have expertise in delivering services to families experiencing adversities and noted points of consensus and of divergence among these stakeholders. We have taken up the challenge of considering the Australian system from the point of view of families who typically find services hard to use.Results and ConclusionWe put forward a model that frames the characteristics of services that can inclusively engage with families - Approachable, Acceptable, Affordable, Accessible and Appropriate. We argue that more needs to be known about appropriateness and what effective pedagogy looks like on the ground for families and children.
Characterization of anoikis-based molecular heterogeneity in pancreatic cancer and pancreatic neuroendocrine tumor and its association with tumor immune microenvironment and metabolic remodeling
Authors: Li Ning , Jia Xingqing , Wang Zhong , Wang Kaige , Qu Zumin , Chi Dong , Sun Zhubo , Jiang Jian , Cui Yougang , Wang Changmiao 
Published: May 2023

BackgroundAccumulating evidence suggests that anoikis plays a crucial role in the onset and progression of pancreatic cancer (PC) and pancreatic neuroendocrine tumors (PNETs); nevertheless, the prognostic value and molecular characteristics of anoikis in cancers are yet to be determined.Materials and methodsWe gathered and collated the multi-omics data of several human malignancies using the TCGA pan-cancer cohorts. We thoroughly investigated the genomics and transcriptomics features of anoikis in pan-cancer. We then categorized a total of 930 patients with PC and 226 patients with PNETs into distinct clusters based on the anoikis scores computed through single-sample gene set enrichment analysis. We then delved deeper into the variations in drug sensitivity and immunological microenvironment between the various clusters. We constructed and validated a prognostic model founded on anoikis-related genes (ARGs). Finally, we conducted PCR experiments to explore and verify the expression levels of the model genes.ResultsInitially, we identified 40 differentially expressed anoikis-related genes (DE-ARGs) between pancreatic cancer (PC) and adjacent normal tissues based on the TCGA, GSE28735, and GSE62452 datasets. We systematically explored the pan-cancer landscape of DE-ARGs. Most DE-ARGs also displayed differential expression trends in various tumors, which were strongly linked to favorable or unfavorable prognoses of patients with cancer, especially PC. Cluster analysis successfully identified three anoikis-associated subtypes for PC patients and two anoikis-associated subtypes for PNETs patients. The C1 subtype of PC patients showed a higher anoikis score, poorer prognosis, elevated expression of oncogenes, and lower level of immune cell infiltration, whereas the C2 subtype of PC patients had the exact opposite characteristics. We developed and validated a novel and accurate prognostic model for PC patients based on the expression traits of 13 DE-ARGs. In both training and test cohorts, the low-risk subpopulations had significantly longer overall survival than the high-risk subpopulations. Dysregulation of the tumor immune microenvironment could be responsible for the differences in clinical outcomes between low- and high-risk groups.ConclusionsThese findings provide fresh insights into the significance of anoikis in PC and PNETs. The identification of subtypes and construction of models have accelerated the progress of precision oncology.
COVID‐19 and sarcopenia-related traits: a bidirectional Mendelian randomization study
Authors: Liu Chao , Liu Ningyuan , Zeng Yi , Xiao Bo , Wang Pingxiao , Zhou Chuqiao , Xia Yu , Zhao Ziyue , Xiao Tao , Li Hui 
Published: May 2023

BackgroundEmerging evidence suggested that coronavirus disease 2019 (COVID-19) patients were more prone to acute skeletal muscle loss and suffer sequelae, including weakness, arthromyalgia, depression and anxiety. Meanwhile, it was observed that sarcopenia (SP) was associated with susceptibility, hospitalization and severity of COVID-19. However, it is not known whether there is causal relationship between COVID‐19 and SP-related traits. Mendelian randomization (MR) was a valid method for inferring causality.MethodsData was extracted from the COVID‐19 Host Genetic Initiative and the UK Biobank without sample overlapping. The MR analysis was performed with inverse variance weighted, weighted median, MR-Egger, RAPS and CAUSE, MR-APSS. Sensitivity analysis was conducted with MR-Egger intercept test, Cochran’s Q test, MR-PRESSO to eliminate pleiotropy.ResultsThere was insufficient result in the MR-APSS method to support a direct causal relationship after the Bonferroni correction. Most other MR results were also nominally consistent with the MR-APSS result.ConclusionsOur study first explored the causal relationship between COVID-19 and SP-related traits, but the result indicated that they may indirectly interact with each other. We highlighted that older people had better absorb enough nutrition and strengthen exercise to directly cope with SP during the COVID-19 pandemic.
Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
Authors: Hisbiyah Yuni , Endaryanto Anang , Setyoboedi Bagus , Rochmah Nur , Faizi Muhammad , Fedora Katherine 
Published: May 2023

BackgroundChildren with Down syndrome (DS) are prone to developing autoimmune thyroid disease (AITD). Previous studies found lower selenium (Se) levels in children with AITD. Glutathione peroxidase-3 (GPx3) and selenoprotein-P (SePP) are widely used to measure Se levels. DS children tend to have lower Se levels, the main contributor to hypothyroidism in this population. This study aimed to analyze the Se’s role in AITD in Indonesian children with DS.MethodsThis cross-sectional study was conducted between February 2021-June 2022 at the Pediatric Outpatient Clinic of Dr Soetomo Hospital. DS children aged 1 month to 18 years were enrolled using consecutive sampling. Thyroid-stimulating hormone, free thyroxine, thyroid peroxidase (TPO-Ab) and thyroglobulin (Tg-Ab) autoantibody, GPx3, and SePP levels were measured in plasma samples using enzyme-linked immunosorbent assays. Statistical analyses used Chi-square, Mann–Whitney, and Spearman’s rank correlation (rs). All results with p&lt;0.05 were considered statistically significant.ResultsAmong 62 children with DS, SePP and GPx3 levels were significantly lower in those with AITD than those without AITD (p=0.013 and p=0.018, respectively). SePP and GPx3 levels correlated significantly with lower TPO-Ab (rs=−0.439 with p=1×10-5 and rs=−0.396 with p=0.001, respectively) and Tg-Ab (rs=−0.474 with p=1×10-5 and rs=−0.410 with p=0.001, respectively) levels. SePP levels correlated significantly with lower thyroid dysfunction incidence (rs=-0.252, p=0.048) in the AITD group.ConclusionSelenium deficiency contributes to autoimmune process in the thyroid and to thyroid dysfunction in children with Down syndrome. Our findings recommend increasing Se levels through Se-containing foods to reduce the risks of AITD and thyroid dysfunction in DS children with AITD.
Coordinated development of regional resources, environment, and economic growth under the background of low-carbon economy
Authors: Wang Ziwen 
Published: May 2023

IntroductionAt present, the rapid growth of social and economic development has also brought great challenges to the development of regional resources and environment. With the deepening of the concept of sustainable development, the coordinated development of regional resources, environment and economic growth has attracted more and more attention. The coordinated development of resources, environment and economic growth is not only the engine of industrial growth, but also the accelerator to promote industrial transfer and optimal allocation of resources, which has injected a strong impetus into social development. However, with the continuous upgrading of the industrial structure, environmental pollution, unbalanced economic development, resource shortage and other problems have gradually emerged in various important development areas.MethodsIn order to effectively solve this dilemma, this paper takes the Beijing-Tianjin-Hebei region (BTH) as an example, based on the analysis of the current situation of the economic and environmental development of BTH region and the influencing factors, combined with the background of low-carbon economy (LCE), effectively studies the coordinated development of its resources, environment and economic growth. In order to verify the effectiveness of low-carbon economic development, this paper, based on the actual development data of BTH region, tests the three dimensions of economic benefit index, environmental benefit index and emission reduction efficiency index.ResultsThe results show that the average environmental benefit index of 13 cities in the BTH region after the implementation of the target is about 0.457. The average benefit index before the implementation of the target was about 0.449.DiscussionFrom the final results of the test, it can be seen that the development of low-carbon economy has strong feasibility for promoting the coordinated development of regional resources, environment and economic growth.
Study on the effect of activated coal gangue on the mechanical and hydration properties of cement
Authors: Zhu Zewen , Liu Chaoqun , Mao Lin , Han Zhixing , Chen Leiwei , Zou Huijie , Li Lianghua , Yu Pengfei , Dong Jingliang , Zhang Yonggang 
Published: May 2023

This study aims to minimize the carbon emissions of cement and investigate the viability of employing activated coal gangue (CG) as an additional cementitious ingredient. This paper investigated the effects of water-cement ratio, ages, and amount of activated CG dosing on the compressive and flexural strength of cement mortar as well as the effects of activated CG on hydration products, hydration process, and hydration degree. The impacts of activated CG on the hydration products and microstructure of cement were examined using XRD, SEM, and TG/DTG systems. A large amount of active SiO2 and Al2O3 in the activated CG react with Ca(OH)2 leading to a secondary hydration reaction in cement. The hydrated calcium silicate and hydrated calcium aluminate gels produced by the subsequent hydration process can reduce the porosity of hardened cement and boost cement mortar strength. The 28 days flexural and compressive strengths of specimens with 30wt.% activated CG rise by 11.69% and 11.82%, respectively, in comparison to that of specimens with 30wt.% quartz powder. When activated CG is mixed with cement, the early hydration rate of the cement can be decreased while the later hydration rate is increased.
Multidrug-resistant organism-peritoneal dialysis associated peritonitis: clinical and microbiological features and risk factors of treatment failure
Authors: Guo Shizheng , Yang Liming , Zhu Xueyan , Zhang Xiaoxuan , Meng Lingfei , Li Xinyang , Cheng Siyu , Zhuang Xiaohua , Liu Shengmao , Cui Wenpeng 
Published: May 2023

BackgroundMultidrug-resistant (MDR) bacterial infection causes difficulty in the therapy of peritoneal dialysis-associated peritonitis (PDAP); however, there are few studies on multidrug-resistant organism (MDRO)-PDAP. In view of growing concerns about MDRO-PDAP, the aim of this study was to investigate the clinical features, risk factors of treatment failure, and causative pathogens of MDRO-PDAP.MethodsIn total, 318 patients who underwent PD between 2013 and 2019 were included in this multicenter retrospective study. Clinical features, patient outcomes, factors related to treatment failure, and microbiological profiles associated with MDRO-PDAP were analyzed and risk factors for treatment failure associated with MDR-Escherichia coli (E. coli) were further discussed.ResultsOf 1,155 peritonitis episodes, 146 eligible episodes of MDRO-PDAP, which occurred in 87 patients, were screened. There was no significant difference in the composition ratio of MDRO-PDAP between 2013–2016 and 2017–2019 (p &gt; 0.05). E. coli was the most prevalent MDRO-PDAP isolate, with high sensitivity to meropenem (96.0%) and piperacillin/tazobactam (89.1%). Staphylococcus aureus was the second most common isolate and was susceptible to vancomycin (100%) and linezolid (100%). Compared to non-multidrug-resistant organism-PDAP, MDRO-PDAP was associated with a lower cure rate (66.4% vs. 85.5%), higher relapse rate (16.4% vs. 8.0%), and higher treatment failure rate (17.1% vs.6.5%). Dialysis age [odds ratio (OR): 1.034, 95% confidence interval (CI): 1.016–1.052, p &lt; 0.001] and &gt;2 previous peritonitis episodes (OR: 3.400, 95% CI: 1.014–11.400, p = 0.047) were independently associated with treatment failure. Furthermore, longer dialysis age (OR: 1.033, 95% CI: 1.003–1.064, p = 0.031) and lower blood albumin level (OR: 0.834, 95% CI: 0.700–0.993, p = 0.041) increased the risk of therapeutic failure for MDR-E. coli infection.ConclusionThe proportion of MDRO-PDAP has remained high in recent years. MDRO infection is more likely to result in worse outcomes. Dialysis age and previous multiple peritonitis infections were significantly associated with treatment failure. Treatment should be promptly individualized based on local empirical antibiotic and drug sensitivity analyses.