bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of mating type, spore killing, and pathogenicity of Fusarium verticillioides populations from maize in China
Authors: Zhang Fengcheng , Tang Tingting , Li Fan , Guo Wei 
Published: August 2023

AbstractSexual reproduction in fungi promotes genetic diversity and helps the fungus to adapt to environmental stresses. Fusarium verticillioides is a heterothallic filamentous ascomycete that is a major cause of maize ear and stalk rot worldwide, while also posing a threat to human and animal health by producing various mycotoxins. Sexual reproduction in F. verticillioides is controlled by the MAT-1 and MAT-2 loci, which mandate that only strains of opposite mating types can mate to yield perithecia and ascospores. Nevertheless, there exists a phenomenon called ‘spore killing’, in which only four typical ascospores appear in the asci following a cross between a strain carrying the spore killer allele (SkK) and one with the spore killer sensitive allele (SkS). In this study, 31 isolates of F. verticillioides collected from eight provinces in China during the maize growing season from 2014 to 2020 were compared based on their mating type, spore killing genotype, and pathogenicity. To determine the mating types and spore killing genotypes of these isolates, partial sequences were amplified from the MAT loci and the SKC1 gene, respectively. The PCR results showed that out of the 31 isolates, 18 were MAT-1 and 13 were MAT-2, and that 25 had SkK genotypes and 6 had SkS genotypes. Genetic crosses between LNF15-11 (MAT-2) and 18 MAT-1 isolates produced normal perithecia with varying numbers. However, crosses between LNF15-11 and the 3 isolates (SDF18-36, HNF14-8, and GSF19-6) produced only four ascospores per ascus, while the remaining isolates except SDF18-28, yielded eight ascospores per ascus. These findings suggest that the SKC1 amplicon variation can be used to differentiate SkK and SkS genotypes in the field and that the 3 isolates are truly SkS genotypes with the MAT-1 allele. Altogether, this study contributes to our knowledge of the mating type and spore killing genotype of F. verticillioides in China and offers valuable strain resources for investigating heterothallic sexual reproduction.
British Society of Echocardiography guideline for the transthoracic echocardiographic assessment of cardiac amyloidosis
Authors: Moody William E. , Turvey-Haigh Lauren , Knight Daniel , Coats Caroline J. , Cooper Robert M. , Schofield Rebecca , Robinson Shaun , Harkness Allan , Oxborough David L. , Gillmore Julian D. , Whelan Carol , Augustine Daniel X. , Fontana Marianna , Steeds Richard P. 
Published: August 2023

AbstractThese guidelines form an update of the BSE guideline protocol for the assessment of restrictive cardiomyopathy (Knight et al. in Echo Res Prac, 2013). Since the original recommendations were conceived in 2013, there has been an exponential rise in the diagnosis of cardiac amyloidosis fuelled by increased clinician awareness, improvements in cardiovascular imaging as well as the availability of new and effective disease modifying therapies. The initial diagnosis of cardiac amyloidosis can be challenging and is often not clear-cut on the basis of echocardiography, which for most patients presenting with heart failure symptoms remains the first-line imaging test. The role of a specialist echocardiographer will be to raise the suspicion of cardiac amyloidosis when appropriate, but the formal diagnosis of amyloid sub-type invariably requires further downstream testing. This document seeks to provide a focused review of the literature on echocardiography in cardiac amyloidosis highlighting its important role in the diagnosis, prognosis and screening of at risk individuals, before concluding with a suggested minimum data set, for use as an aide memoire when reporting.
Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031
Authors: Cash Thomas , Krailo Mark D. , Buxton Allen B. , Pawel Bruce R. , Healey John H. , Binitie Odion , Marcus Karen J. , Grier Holcombe E. , Grohar Patrick J. , Reed Damon R. , Weiss Aaron R. , Gorlick Richard , Janeway Katherine A. , DuBois Steven G. , Womer Richard B. 
Published: August 2023

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned coprimary or secondary analyses are not yet available. Clinical trial updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Long-term outcomes from Children's Oncology Group study AEWS0031 were assessed to determine whether the survival advantage of interval-compressed chemotherapy (ICC) was maintained over 10 years in patients with localized Ewing sarcoma (ES). AEWS0031 enrolled 568 eligible patients. Patients were randomly assigned to receive vincristine-doxorubicin-cyclophosphamide and ifosfamide-etoposide alternating once every 3 weeks (standard timing chemotherapy [STC]) versus once every 2 weeks (ICC). For this updated report, one patient was excluded because of uncertainty of original diagnosis. The 10-year event-free survival (EFS) was 70% with ICC compared with 61% with STC ( P = .03), and 10-year overall survival (OS) was 76% with ICC compared with 69% with STC ( P = .04). There was no difference in the 10-year cumulative incidence of second malignant neoplasms (SMNs; PC [see Data Supplement, online only] = .5). A test for interaction demonstrated that ICC provided greater risk reduction for patients with tumor volume ≥200 mL than for patients with tumors <200 mL, but no evidence for a significant interaction in other subgroups defined by age, primary site, and histologic response. With longer-term follow-up, ICC for localized ES is associated with superior EFS and OS without an increased risk for SMN compared with STC. ICC is associated with improved outcomes even in adverse-risk patient groups.
Pan-Cancer Analysis of Postdiagnosis Exercise and Mortality
Authors: Lavery Jessica A. , Boutros Paul C. , Scott Jessica M. , Tammela Tuomas , Moskowitz Chaya S. , Jones Lee W. 
Published: August 2023

PURPOSE The impact of postdiagnosis exercise on cause-specific mortality in cancer survivors and whether this differs on the basis of cancer site is unclear. METHODS We performed an analysis of 11,480 patients with cancer enrolled in the Prostate, Lung, Colorectal, and Ovarian cancer screening trial. Patients with a confirmed diagnosis of cancer completing a standardized survey quantifying exercise after diagnosis were included. The primary outcome was all-cause mortality (ACM); secondary end points were cancer mortality and mortality from other causes. Cox models were used to estimate the cause-specific hazard ratios (HRs) for ACM, cancer, and noncancer mortality as a function of meeting exercise guidelines versus not meeting guidelines with adjustment for important clinical covariates. RESULTS After a median follow-up of 16 years from diagnosis, 4,665 deaths were documented (1,940 due to cancer and 2,725 due to other causes). In multivariable analyses, exercise consistent with guidelines was associated with a 25% reduced risk of ACM compared with nonexercise (HR, 0.75; 95% CI, 0.70 to 0.80). Compared with nonexercise, exercise consistent with guidelines was associated with a significant reduction in cancer mortality (HR, 0.79; 95% CI, 0.72 to 0.88) and mortality from other causes (HR, 0.72; 95% CI, 0.66 to 0.78). The inverse relationship between exercise and cause-specific mortality varied by exercise dose. Exercise consistent with guidelines was associated with a reduced hazard of ACM for multiple cancer sites. Reduction in cancer mortality for exercisers was only observed in head and neck and renal cancer. CONCLUSION In this pan-cancer sample of long-term cancer survivors, exercise consistent with guidelines was associated with substantial ACM benefit driven by both reductions in cancer and noncancer mortality. The cause-specific impact of exercise differed as a function of cancer site.
Tisotumab Vedotin in Combination With Carboplatin, Pembrolizumab, or Bevacizumab in Recurrent or Metastatic Cervical Cancer: Results From the innovaTV 205/GOG-3024/ENGOT-cx8 Study
Authors: Vergote Ignace , Van Nieuwenhuysen Els , O'Cearbhaill Roisin E. , Westermann Anneke , Lorusso Domenica , Ghamande Sharad , Collins Dearbhaile C. , Banerjee Susana , Mathews Cara A. , Gennigens Christine , Cibula David , Tewari Krishnansu S. , Madsen Kristine , Köse Fatih , Jackson Amanda L. , Boere Ingrid A. , Scambia Giovanni , Randall Leslie M. , Sadozye Azmat , Baurain Jean-François , Gort Eelke , Zikán Michal , Denys Hannelore G. , Ottevanger Nelleke , Forget Frédéric , Mondrup Andreassen Camilla , Eaton Lamar , Chisamore Michael J. , Viana Nicacio Leonardo , Soumaoro Ibrahima , Monk Bradley J. 
Published: August 2023

PURPOSE Tissue factor is highly expressed in cervical carcinoma and can be targeted by tisotumab vedotin (TV), an antibody-drug conjugate. This phase Ib/II study evaluated TV in combination with bevacizumab, pembrolizumab, or carboplatin for recurrent or metastatic cervical cancer (r/mCC). METHODS This open-label, multicenter study (ClinicalTrials.gov identifier: NCT03786081 ) included dose-escalation arms that assessed dose-limiting toxicities (DLTs) and identified the recommended phase II dose (RP2D) of TV in combination with bevacizumab (arm A), pembrolizumab (arm B), or carboplatin (arm C). The dose-expansion arms evaluated TV antitumor activity and safety at RP2D in combination with carboplatin as first-line (1L) treatment (arm D) or with pembrolizumab as 1L (arm E) or second-/third-line (2L/3L) treatment (arm F). The primary end point of dose expansion was objective response rate (ORR). RESULTS A total of 142 patients were enrolled. In dose escalation (n = 41), no DLTs were observed; the RP2D was TV 2 mg/kg plus bevacizumab 15 mg/kg on day 1 once every 3 weeks, pembrolizumab 200 mg on day 1 once every 3 weeks, or carboplatin AUC 5 on day 1 once every 3 weeks. In dose expansion (n = 101), the ORR was 54.5% (n/N, 18/33; 95% CI, 36.4 to 71.9) with 1L TV + carboplatin (arm D), 40.6% (n/N, 13/32; 95% CI, 23.7 to 59.4) with 1L TV + pembrolizumab (arm E), and 35.3% (12/34; 19.7 to 53.5) with 2L/3L TV + pembrolizumab (arm F). The median duration of response was 8.6 months, not reached, and 14.1 months, in arms D, E, and F, respectively. Grade ≥3 adverse events (≥15%) were anemia, diarrhea, nausea, and thrombocytopenia in arm D and anemia in arm F (none ≥15%, arm E). CONCLUSION TV in combination with bevacizumab, carboplatin, or pembrolizumab demonstrated manageable safety and encouraging antitumor activity in treatment-naive and previously treated r/mCC.
Synthesis and In Vitro Anti-tumor Evaluation of Novel Glycoconjugated SN38 Derivatives
Authors: Wang Xin , Yang Chao , Liao Mengya , Xie Yongmei , Yang Jinliang 
Published: August 2023

Abstract
Five types of novel glycoconjugated 7-ethyl-10-hydroxycamptothecin (SN38) derivatives were synthesized to evaluate their anti-tumor activity against HCT116 human colon cancer cells, and the results showed that all of them demonstrated potent anti-tumor activity. Notably, glucose and galactose conjugates exhibited the better anti-tumor activity, while the mannose and allose conjugates had slightly lower activity. Our findings suggested that the anti-tumor activity of glycoconjugated SN38 derivatives was affected by the type of modifying molecule used and the position of the modification. These findings could have implications for the development of novel anti-tumor agents targeting glucose transporters.
Synthesis, Characterization, and Solar Cell Applications of a Non-fused-ring Electron Acceptor Based on Vinylene-bridged Difluorobenzothiadiazole
Authors: Mori Hiroki , Hasegawa Natsuki , Yoshino Tomoki , Nishihara Yasushi 
Published: August 2023

Abstract
A new non-fused-ring electron acceptor (NREA), BE4T based on vinylene-bridged difluorobenzothiadiazole (FBTzE) has been synthesized and characterized. BE4T was found to be suitable for high-performance OPVs due to its strong absorption around 600–800 nm and low-lying HOMO/LUMO energy levels. However, BE4T-based cells showed a low PCE of 1.05% owing to the formation of highly ordered edge-on and large phase separation structure in the blended films.
Assessing the impact of hospital marketing in attracting the patient for service consumption in tertiary care hospital in central India.
Authors: Sheikh Yohana , Kanyal Deepika 
Published: August 2023

Background: Hospital service is a field that is constantly changing, with the availability of creativity, opportunities motivating passion, and allowing experts to thrive. Healthcare marketing is a scientific discipline since it uses concepts, plans, and methods that are exclusive to both conventional and social marketing. The importance of this study is to build up the bridge and relationship between the hospital and the patient. To introduce the healthcare services to the patient to let them know what services the hospital provides and what advantages they will receive for their health betterment. With the help of this study, we can track the flow of the patient from which median they are coming, for example, traditional marketing or digital marketing. This study will promote and analyse where the marketing strategies are lacking and where they need to be improved with the help of recommendations of this study. The objectives of this study to bridge the gap by providing the corrective information and developing the relationship between patient and hospital, to create a leadership position and differentiate from competitors. Methods: A retrospective study approach will be adopted in the study. It includes a collection of data and information direct from the marketing department. Study will be conducted in the tertiary care hospital of central India. Secondary type of data will be collected from the Hospital Management Information system. Expected Result: The expected result of the study will be to bridge the gap by providing the corrective information and developing the relationship between patient and hospital, to create a leadership position and differentiate from competitors to know where the institute is standing in the market.
Early age strength of ambient-cured geopolymer mortars from waste concrete and bricks with different alkaline activators.
Authors: Kogbara Reginald B. , Al-Zubi Abdelrahman , Masad Eyad A. 
Published: August 2023

Background: The dataset in this work emanates from preliminary studies comparing early-age compressive strengths of geopolymer mortars produced from construction and demolition wastes (CDW) commonly found in Qatar using different alkaline activators. Methods: Waste concrete, waste bricks and steel slag - an industrial waste produced in large quantities in the country - were used as aluminosilicate sources. Waste concrete was used as fine aggregate (75 μm to 4 mm), while solid or hollow red clay bricks were used together with steel slag as aluminosilicate powders. Solid red clay brick (75 μm to 1.4 mm) was also used as fine aggregate in some mixes. Different alkaline activators including solid powder or ground pellet forms of Ca(OH)2, CaO, and Ca(OH)2-NaOH, NaOH-CaCO3 and Na2SiO3-Na2CO3-Ca(OH)2 mixtures were employed by just adding water. A few mixes included both solid powder Ca(OH)2 and viscous solutions of NaOH and NaOH-Na2SiO3 as alkaline activators. The geopolymer mortars also included small amounts of some other additives such as gypsum, microsilica and aluminium sulfate to enhance the geopolymerization and hydration process. Random proportions of the materials were considered in the range-finding experiments, and the mortars produced were tested for compressive strength. Results: The data show the 7-day compressive strengths and densities of the 40 mixtures considered with mostly ambient temperature (20°C) curing. It also shows such data for mixtures in which variables such as curing at 40°C, mixing with hot water at 50 - 60°C temperature, grading of waste concrete aggregates, and collective grinding of the powdered materials were considered. Conclusions: The dataset shows possible early-age compressive strengths of different geopolymer mortar mixture designs and the materials and mixture design methods that can be used to achieve desired early-age strengths from waste concrete and bricks.
THz time-domain spectroscopy modulated with semiconductor plasmonic perfect absorbers
Authors: Gonzalez-Posada Fernando , Coquillat Dominique , Najem Melissa , Cerutti Laurent , Taliercio Thierry 
Published: August 2023

Terahertz time-domain spectroscopy (THz-TDS) at room temperature and standard atmosphere pressure remains so far the backbone of THz photonics in numerous applications for civil and defense levels. Plasmonic microstructures and metasurfaces are particularly promising for improving THz spectroscopy techniques and developing biomedical and environmental sensors. Highly doped semiconductors are suitable for replacing the traditional plasmonic noble metals in the THz range. We present a perfect absorber structure based on semiconductor III-Sb epitaxial layers. The insulator layer is GaSb while the metal-like layers are Si doped InAsSb (∼ 5·1019 cm-3). The doping is optically measured in the IR with polaritonic effects at the Brewster angle mode. Theoretically, the surface can be engineered in frequency selective absorption array areas of an extensive THz region from 1.0 to 6.0 THz. The technological process is based on a single resist layer used as hard mask in dry etching defined by electron beam lithography. A wide 1350 GHz cumulative bandwidth experimental absorption is measured in THz-TDS between 1.0 and 2.5 THz, only limited by the air-exposed reflectance configuration. These results pave the way to implement finely tuned selective surfaces based on semiconductors to enhance light-matter interaction in the THz region.
Protocol for secondary data analysis of 4 UK cohorts examining youth adversity and mental health in the context of intersectionality
Authors: Hosang Georgina Mayling , Havers Laura , Shuai Ruichong , Fonagy Peter , Fazel Mina , Morgan Craig , Karamanos Alexis , Fancourt Daisy , McCrone Paul , Smuk Melanie , Bhui Kamaldeep , Shakoor Sania 
Published: August 2023

BackgroundYouth adversity (e.g., abuse and bullying victimisation) is robust risk factor for later mental health problems (e.g., depression and anxiety). Research shows the prevalence of youth adversity and rates of mental health problems vary by individual characteristics, identity or social groups (e.g., gender and ethnicity). However, little is known about whether the impact of youth adversity on mental health problems differ across the intersections of these characteristics (e.g., white females). This paper reports on a component of the ATTUNE research programme (work package 2) which aims to investigate the impact and mechanisms of youth adversity on depressive and anxiety symptoms in young people by intersectionality profiles.MethodsThe data are from 4 UK adolescent cohorts: HeadStart Cornwall, Oxwell, REACH, and DASH. These cohorts were assembled for adolescents living in distinct geographical locations representing coastal, suburban and urban places in the UK. Youth adversity was assessed using a series of self-report questionnaires and official records. Validated self-report instruments measured depressive and anxiety symptoms. A range of different variables were classified as possible social and cognitive mechanisms.Results and analysisStructural equation modelling (e.g., multiple group models, latent growth models) and multilevel modelling will be used, with adaptation of methods to suit the specific available data, in accord with statistical and epidemiological conventions.DiscussionThe results from this research programme will broaden our understanding of the association between youth adversity and mental health, including new information about intersectionality and related mechanisms in young people in the UK. The findings will inform future research, clinical guidance, and policy to protect and promote the mental health of those most vulnerable to the negative consequences of youth adversity.
Western Australian medical students’ attitudes towards artificial intelligence in healthcare
Authors: Stewart Jonathon , Lu Juan , Gahungu Nestor , Goudie Adrian , Fegan P. Gerry , Bennamoun Mohammed , Sprivulis Peter , Dwivedi Girish 
Published: August 2023

Introduction
Surveys conducted internationally have found widespread interest in artificial intelligence (AI) amongst medical students. No similar surveys have been conducted in Western Australia (WA) and it is not known how medical students in WA feel about the use of AI in healthcare or their understanding of AI. We aim to assess WA medical students’ attitudes towards AI in general, AI in healthcare, and the inclusion of AI education in the medical curriculum.

Methods
A digital survey instrument was developed based on a review of available literature and consultation with subject matter experts. The survey was piloted with a group of medical students and refined based on their feedback. We then sent this anonymous digital survey to all medical students in WA (approximately 1539 students). Responses were open from the 7th of September 2021 to the 7th of November 2021. Students’ categorical responses were qualitatively analysed, and free text comments from the survey were qualitatively analysed using open coding techniques.

Results
Overall, 134 students answered one or more questions (8.9% response rate). The majority of students (82.0%) were 20–29 years old, studying medicine as a postgraduate degree (77.6%), and had started clinical rotations (62.7%). Students were interested in AI (82.6%), self-reported having a basic understanding of AI (84.8%), but few agreed that they had an understanding of the basic computational principles of AI (33.3%) or the limitations of AI (46.2%). Most students (87.5%) had not received teaching in AI. The majority of students (58.6%) agreed that AI should be part of medical training and most (72.7%) wanted more teaching focusing on AI in medicine. Medical students appeared optimistic regarding the role of AI in medicine, with most (74.4%) agreeing with the statement that AI will improve medicine in general. The majority (56.6%) of medical students were not concerned about the impact of AI on their job security as a doctor. Students selected radiology (72.6%), pathology (58.2%), and medical administration (44.8%) as the specialties most likely to be impacted by AI, and psychiatry (61.2%), palliative care (48.5%), and obstetrics and gynaecology (41.0%) as the specialties least likely to be impacted by AI. Qualitative analysis of free text comments identified the use of AI as a tool, and that doctors will not be replaced as common themes.

Conclusion
Medical students in WA appear to be interested in AI. However, they have not received education about AI and do not feel they understand its basic computational principles or limitations. AI appears to be a current deficit in the medical curriculum in WA, and most students surveyed were supportive of its introduction. These results are consistent with previous surveys conducted internationally.