bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using mechanism-based combinations of H2S-donors to maximize the cardioprotective action of H2S
Authors: Ravani Stella , Chatzianastasiou Athanasia , Papapetropoulos Andreas 
Published: September 2023

Abstract H2S-donors are cardioprotective in ischemia/reperfusion (I/R) injury. Some H2S-donors exert their beneficial effects in a nitric oxide (NO)-dependent manner, while others act using NO-independent pathways. The aims of the present study were to (i) evaluate whether H2S-donors with distinct pharmacodynamic properties act synergistically in I/R injury and (ii) determine if H2S-donors remain cardioprotective in obese mice. C57BL/6 mice were subjected to 30 min of ischemia followed by 120 min of reperfusion. Donors were administered intravenously at the end of ischemia (Na2S: 1 μmol/kg, GYY4137: 25 μmol/kg, AP39: 0,25 μmol/kg), while the 3-mercaptopyruvate sulfurtransferase (10 mg/kg) inhibitor was given intraperitonially 1 h prior to ischemia. Infarct size was estimated by 2,3,5-triphenyltetrazolium staining, while the area at risk was calculated using Evans blue. All three donors reduced infarct size when administered as a sole treatment. Co-administration of Na2S/GYY4137, as well as Na2S/AP39 reduced further the I/R injury, beyond what was observed with each individual donor. Since inhibition of the H2S-producing enzyme 3-mercaptopyruvate sulfurtransferase is known to reduce infarct size, we co-administered C3 with Na2S to determine possible additive effects between the two agents. In this case, combination of C3 with Na2S did not yield superior results compared to the individual treatments. Similarly, to what was observed in healthy mice, administration of a H2S-donor (Na2S or AP39) reduced I/R injury in mice rendered obese by consumption of a high fat diet. We conclude that combining a NO-dependent with a NO-independent H2S-donor leads to enhanced cardioprotection and that H2S-donors remain effective in obese animals.
Antioxidant and anti-inflammatory potential of spirulina and thymoquinone mitigate the methotrexate-induced neurotoxicity
Authors: Behairy Alaa , Elkomy Ashraf , Elsayed Faten , Gaballa Mohamed M. S. , Soliman Ahmed , Aboubakr Mohamed 
Published: September 2023

AbstractThe objective of this study was to investigate whether the neurotoxic effects caused by methotrexate (MTX), a frequently used chemotherapy drug, could be improved by administeringSpirulina platensis(SP) and/or thymoquinone (TQ). Seven groups of seven rats were assigned randomly for duration of 21 days. The groups consisted of a control group that was given saline only. The second group was given 500 mg/kg of SP orally; the third group was given 10 mg/kg of TQ orally. The fourth group was given a single IP dose of 20 mg/kg of MTX on the 15thday of the experiment. The fifth group was given both SP and MTX, the sixth group was given both TQ and MTX, and the seventh group was given SP, TQ, and MTX. After MTX exposure, the study found that AChE inhibition, depletion of glutathione, and increased levels of MDA occurred. MTX also decreased the activity of SOD and CAT, as well as the levels of inflammatory mediators such as IL-1, IL-6, and tumor necrosis factor-α. MTX induced apoptosis in brain tissue. However, when MTX was combined with either SP or TQ, the harmful effects on the body were significantly reduced. This combination treatment resulted in a faster return to normal levels of biochemical, oxidative markers, inflammatory responses, and cell death. In conclusion, supplementation with SP or TQ could potentially alleviate MTX-induced neuronal injury, likely due to their antioxidant, anti-inflammatory, and anti-apoptotic effects.
Surgical Management and Outcome of Entero‐Urinary Fistula Complicating Crohn's Disease: A Single Center Study
Authors: Chen Yusheng , Cao Lei , Qiu Jiayin , Li Zhun , Guo Zhen , Zhu Zhenxing , Xu Yihan , Qian Wenwei , Zhu Weiming , Li Yi 
Published: September 2023

AbstractBackgroundEntero‐urinary fistulas (EUF) are a rare complication of Crohn's disease (CD), observed in 1.6 to 7.7%. The management of EUF complicating CD is challenging. We aimed to report the outcome and surgical management of EUF in CD.MethodsA retrospective chart review was performed in all CD patients with EUF who underwent surgery in our center between January 2012 and December 2021. Patient demographics, preoperative optimization, surgical management, postoperative complications, and follow‐up information were collected from a prospectively maintained database.ResultsA total of 74 eligible patients were identified. The median interval between CD diagnosis and EUF diagnosis was 2 (0.08–6.29) years. Patients with EUF presented with pneumaturia (75.68%), urinary tract infections (72.97%), fecaluria (66.22%), and hematuria (6.76%). Fistulae originated most commonly from the ileum (63.51%), followed by the colon (14.86%), the rectum (9.46%), the cecum (2.70%), and multiple sites (9.46%). The EUF symptoms, weight, nutritional status, laboratory results were significantly improved after preoperative optimization. The absence of EUF symptoms was observed in 42 patients after the optimization and only 9 of which required bladder repair. However, 19 of 32 patients whose symptoms did not resolve required bladder repair (P = 0.001). Only 1 patient developed a bladder leakage in the early postoperative period and 3 patients experienced recurrent bladder fistula.ConclusionsSurgical management of EUF complicating CD is effective and safe, with a low rate of postoperative complication and EUF recurrence. Preoperative optimization, which is associated with the resolution of urinary symptoms and improved surgical outcomes, should be recommended.
Giant mitochondria in cardiomyocytes: cellular architecture in health and disease
Authors: Li Amy , Shami Gerald J. , Griffiths Lisa , Lal Sean , Irving Helen , Braet Filip 
Published: September 2023

AbstractGiant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.
Senescent fibro-adipogenic progenitors are potential drivers of pathology in inclusion body myositis
Authors: Nelke Christopher , Schroeter Christina B. , Theissen Lukas , Preusse Corinna , Pawlitzki Marc , Räuber Saskia , Dobelmann Vera , Cengiz Derya , Kleefeld Felix , Roos Andreas , Schoser Benedikt , Brunn Anna , Neuen-Jacob Eva , Zschüntzsch Jana , Meuth Sven G. , Stenzel Werner , Ruck Tobias 
Published: September 2023

AbstractInclusion body myositis (IBM) is unique across the spectrum of idiopathic inflammatory myopathies (IIM) due to its distinct clinical presentation and refractoriness to current treatment approaches. One explanation for this resistance may be the engagement of cell-autonomous mechanisms that sustain or promote disease progression of IBM independent of inflammatory activity. In this study, we focused on senescence of tissue-resident cells as potential driver of disease. For this purpose, we compared IBM patients to non-diseased controls and immune-mediated necrotizing myopathy patients. Histopathological analysis suggested that cellular senescence is a prominent feature of IBM, primarily affecting non-myogenic cells. In-depth analysis by single nuclei RNA sequencing allowed for the deconvolution and study of muscle-resident cell populations. Among these, we identified a specific cluster of fibro-adipogenic progenitors (FAPs) that demonstrated key hallmarks of senescence, including a pro-inflammatory secretome, expression of p21, increased β-galactosidase activity, and engagement of senescence pathways. FAP function is required for muscle cell health with changes to their phenotype potentially proving detrimental. In this respect, the transcriptomic landscape of IBM was also characterized by changes to the myogenic compartment demonstrating a pronounced loss of type 2A myofibers and a rarefication of acetylcholine receptor expressing myofibers. IBM muscle cells also engaged a specific pro-inflammatory phenotype defined by intracellular complement activity and the expression of immunogenic surface molecules. Skeletal muscle cell dysfunction may be linked to FAP senescence by a change in the collagen composition of the latter. Senescent FAPs lose collagen type XV expression, which is required to support myofibers’ structural integrity and neuromuscular junction formation in vitro. Taken together, this study demonstrates an altered phenotypical landscape of muscle-resident cells and that FAPs, and not myofibers, are the primary senescent cell type in IBM.
Assessing the quality of care for skin malignant melanoma on a global, regional, and national scale: a systematic analysis of the global burden of disease study from 1990 to 2019
Authors: Liu Mingjuan , Wu Mengyin , Liu Xintong , Zhou Jia , Lan Yining , Zhang Hanlin , zhang Xinyi , Leng Ling , Zheng Heyi , Li Jun 
Published: September 2023

AbstractMalignant melanoma (MM) is a highly aggressive form of skin cancer with increasing global incidence rates, particularly in developed countries. Variations in the prevalence and quality of care provided to patients with melanoma exist across different regions and across different sex and age. Assessing the global burden of melanoma and evaluating the quality of care can provide valuable insights for developing targeted interventions in certain underperforming regions and improving patient outcomes. This study aimed to systematically analyze the Global Burden of Disease Study from 1990 to 2019 to assess the quality of care for skin malignant melanoma on a global scale. We conducted a comprehensive literature review and extracted data on melanoma incidence, mortality, and disability-adjusted life years (DALYs) from the Global Burden of Disease Study. We incorporated these variables using principal component analysis (PCA) to form an informative single variable of quality of care index (QCI) and analyzed its spatial–temporal variations as well as disparities across age, sex and socio-demographic index (SDI). The overall Quality of Care Index (QCI) for melanoma improved from 82.81 in 1990 to 91.29 in 2019. The QCI score showed a positive correlation with socioeconomic status across regions. Australia ranked highest in QCI (99.96), while Central African Republic, and Kiribati had the lowest scores. China and Saudi Arabia showed significant QCI improvement, while the QCI of the Democratic People's Republic of Korea, Zimbabwe, and Guam decreased from 1990 to 2019. The highest QCI scores were observed in the age groups of 20–39 years old (93.40–94.65). Gender disparities narrowed globally in these three decades, but lower Socio-demographic Index (SDI) regions showed increased gender inequities. Our findings highlighted the spatial–temporal variations in the quality of care of MM as well as its disparities across different SDI levels, age groups and sex. These findings offer valuable insights and guidance for implementing focused interventions and resource allocation to enhance the quality of care and overall outcomes for MM worldwide, especially for underperforming regions.
Evaluation of insertion quality of a slim perimodiolar electrode array
Authors: Beck R. , Aschendorff A. , Arndt S. , Hildenbrand T. , Rauch A. K. , Ketterer M. C. 
Published: September 2023

Abstract
Objectives
The influence of cochlear morphology and electrode array design on scalar position and dislocation rates is of great interest in CI surgery. The aim of this study is to evaluate scalar position and specific points of dislocation in relation to cochlear morphology in patients implanted with a new slim perimodiolar electrode array.

Materials and methods
Patients were implanted using the slim modiolar electrode array (= SMA) (= 532/632 electrode array of Cochlear™). Postoperative imaging was performed via cone beam computed tomography (CBCT) and the scans were analyzed regarding cochlear morphology (distances A and B and cochlear height), scalar location of the electrode array, basal insertion depth and apical insertion angle. Furthermore, electrode array design and surgical protocols were evaluated.

Results
81 ears implanted with the SMA were retrospectively included. We evaluated 3 electrode array tip fold over intraoperatively via X-ray imaging and performed revision during the same surgery. The CBCT scans showed 76 initial scala tympani (ST) insertions without dislocation. Two ears showed a dislocated array, one at 77° and the other at 163°. Three arrays were inserted into scala vestibuli (SV) via cochleostomy. These patients showed no signs of obliteration. Cochlear morphology showed no influence on angular insertion depth and scalar position.

Conclusions
The SMA showed a very low rate of scalar dislocations due to its slim electrode array design (2.7%). We could find a learning curve regarding the handling and the risk of dislocation and tip fold over with this electrode array. The rate of intraoperative tip fold over detection via X-ray imaging was 3.7%. Therefore, we highly recommend X-ray imaging and transimpedance matrix measurements within the surgery protocol. Scala vestibuli insertions happened in patients with cochleostomy only. We could identify two specific points of dislocation depending on electrode array design.
Extracellular vesicles in kidney development and pediatric kidney diseases
Authors: Ergunay Tunahan , Collino Federica , Bianchi Gaia , Sedrakyan Sargis , Perin Laura , Bussolati Benedetta 
Published: September 2023

AbstractExtracellular vesicles (EVs) are membranous cargo particles that mediate intercellular communication. They are heterogeneous in size and mechanism of release, and found in all biological fluids. Since EV content is in relation to the originating cell type and to its physiopathological conditions, EVs are under study to understand organ physiology and pathology. In addition, EV surface cargo, or corona, can be influenced by the microenvironment, leading to the concept that EV-associated molecules can represent useful biomarkers for diseases. Recent studies also focus on the use of natural, engineered, or synthetic EVs for therapeutic purposes. This review highlights the role of EVs in kidney development, pediatric kidney diseases, including inherited disorders, and kidney transplantation. Although few studies exist, they have promising results and may guide researchers in this field. Main limitations, including the influence of age on EV analyses, are also discussed.
Value Distributions of Perfect Nonlinear Functions
Authors: Kölsch Lukas , Polujan Alexandr 
Published: September 2023

AbstractIn this paper, we study the value distributions of perfect nonlinear functions, i.e., we investigate the sizes of image and preimage sets. Using purely combinatorial tools, we develop a framework that deals with perfect nonlinear functions in the most general setting, generalizing several results that were achieved under specific constraints. For the particularly interesting elementary abelian case, we derive several new strong conditions and classification results on the value distributions. Moreover, we show that most of the classical constructions of perfect nonlinear functions have very specific value distributions, in the sense that they are almost balanced. Consequently, we completely determine the possible value distributions of vectorial Boolean bent functions with output dimension at most 4. Finally, using the discrete Fourier transform, we show that in some cases value distributions can be used to determine whether a given function is perfect nonlinear, or to decide whether given perfect nonlinear functions are equivalent.
A Solution to Babai’s Problems on Digraphs with Non-diagonalizable Adjacency Matrix
Authors: Li Yuxuan , Xia Binzhou , Zhou Sanming , Zhu Wenying 
Published: September 2023

AbstractThe fact that the adjacency matrix of every finite graph is diagonalizable plays a fundamental role in spectral graph theory. Since this fact does not hold in general for digraphs, it is natural to ask whether it holds for digraphs with certain level of symmetry. Interest in this question dates back to the early 1980 s, when P. J. Cameron asked for the existence of arc-transitive digraphs with non-diagonalizable adjacency matrix. This was answered in the affirmative by Babai (J Graph Theory 9:363–370, 1985). Then Babai posed the open problems of constructing a 2-arc-transitive digraph and a vertex-primitive digraph whose adjacency matrices are not diagonalizable. In this paper, we solve Babai’s problems by constructing an infinite family of s-arc-transitive digraphs for each integer $$s\ge 2$$

s
≥
2

, and an infinite family of vertex-primitive digraphs, both of whose adjacency matrices are non-diagonalizable.
Automatic detection of weeds: synergy between EfficientNet and transfer learning to enhance the prediction accuracy
Authors: Duong Linh T. , Tran Toan B. , Le Nhi H. , Ngo Vuong M. , Nguyen Phuong T. 
Published: September 2023

AbstractThe application of digital technologies to facilitate farming activities has been on the rise in recent years. Among different tasks, the classification of weeds is a prerequisite for smart farming, and various techniques have been proposed to automatically detect weeds from images. However, many studies deal with weed images collected in the laboratory settings, and this might not be applicable to real-world scenarios. In this sense, there is still the need for robust classification systems that can be deployed in the field. In this work, we propose a practical solution to recognition of weeds exploiting two versions of EfficientNet as the recommendation engine. More importantly, to make the learning more effective, we also utilize different transfer learning strategies. The final aim is to build an expert system capable of accurately detecting weeds from lively captured images. We evaluate the approach’s performance using DeepWeeds, a real-world dataset with 17,509 images. The experimental results show that the application of EfficientNet and transfer learning on the considered dataset substantially improves the overall prediction accuracy in various settings. Through the evaluation, we also demonstrate that the conceived tool outperforms various state-of-the-art baselines. We expect that the proposed framework can be installed in robots to work on rice fields in Vietnam, allowing farmers to find and eliminate weeds in an automatic manner.
How Market Intervention can Prevent Bubbles and Crashes: An Agent Based Modelling Approach
Authors: Westphal Rebecca , Sornette Didier 
Published: September 2023

AbstractUsing a previously validated agent-based model with fundamentalists and chartists, we investigate the usefulness and impact of direct market intervention. The policy maker diagnoses bubbles by forming an expectation of the future returns, then invests in burgeoning bubbles to develop a sufficient inventory of the risky asset in order to be able to sell adequate amounts of the overpriced asset later countercyclically to fight market exuberance. Preventing bubbles and crashes, this market intervention improves all analysed market return metrics, volatility, skewness, kurtosis and VaR, without affecting long-term growth. This increases the Sharpe ratios of noise traders and of fundamentalists by approximately 28% and 45% respectively. The results are robust even for substantially miscalibrated long-term expected returns.
Per Davidsson: recipient of the 2023 Global Award for Entrepreneurship Research
Authors: Storey David J. , Andersson Martin , Henrekson Magnus , Jack Sarah , Stenkula Mikael , Thorburn Karin , Wigren-Kristoferson Caroline , Zander Ivo 
Published: September 2023

Abstract
Professor Per Davidsson is the recipient of the 2023 Global Award for Entrepreneurship Research. Throughout an extraordinarily productive career, he has made invaluable contributions in building the field of entrepreneurship. His early studies on entrepreneurship and culture and his studies on the growth of small businesses played an important role in the emergence and development of entrepreneurship as a scholarly field of research. He has also, continuously, made more conceptual contributions by critically probing the development of the field, and engaged in writing foundational books that have been used extensively in higher education institutes. By probing and challenging traditional assumptions throughout his career, he has contributed to the refinement and renewal of the field.
„The same or different?“ – Effekte von Unterrichtsanalyse und Unterrichtsreflexion auf die Veränderung kognitiver und motivationaler Merkmale professioneller Lehrkompetenz
Authors: Lohse-Bossenz Hendrik , Schmitt Markus , Lenske Gerlinde , Gold Bernadette 
Published: September 2023

ZusammenfassungDie Analyse von und die Reflexion über Unterricht sind zentrale Elemente universitärer Lehrkräftebildung. Dabei kann sowohl in der Lehre als auch in der Forschung begriffliche Heterogenität bzgl. Reflexion konstatiert werden. Auch fehlt eine klare Abgrenzung zwischen Analyse und Reflexion von Unterricht. Aufbauend auf der Konzeption des Selbstbezugs als ein zentrales Unterscheidungsmerkmal wird mittels eines quasi-experimentellen Prä-Post-Interventions-Kontrollgruppendesigns geprüft, inwiefern sich Unterrichtsanalysen von Unterrichtsreflexionen in ihren Auswirkungen auf die professionelle Unterrichtswahrnehmung (PUW) und die klassenführungsbezogene Selbstwirksamkeit (SW) unterscheiden. An einer Stichprobe von 194 angehenden Lehrkräften im Master of Education einer Hochschule kann gezeigt werden, dass Unterrichtsanalyse und -reflexion vergleichbar positive Effekte auf die PUW zeigten (besser als eine Kontrollgruppe ohne spezifische Intervention). Allerdings zeigt die Reflexionsgruppe eine stärkere Zunahme klassenführungsbezogener SW im Vergleich zu den anderen beiden Gruppen. Die Ergebnisse deuten somit darauf hin, dass durch den expliziten Selbstbezug selbstgerichtete Kognitionen verstärkt thematisiert werden und damit zusätzliche Aspekte professioneller Kompetenz adressiert werden können.
A Reinduction-Based Approach for Efficient High Utility Itemset Mining from Incremental Datasets
Authors: Sra Pushp , Chand Satish 
Published: September 2023

AbstractHigh utility itemset mining is a crucial research area that focuses on identifying combinations of itemsets from databases that possess a utility value higher than a user-specified threshold. However, most existing algorithms assume that the databases are static, which is not realistic for real-life datasets that are continuously growing with new data. Furthermore, existing algorithms only rely on the utility value to identify relevant itemsets, leading to even the earliest occurring combinations being produced as output. Although some mining algorithms adopt a support-based approach to account for itemset frequency, they do not consider the temporal nature of itemsets. To address these challenges, this paper proposes the Scented Utility Miner (SUM) algorithm that uses a reinduction strategy to track the recency of itemset occurrence and mine itemsets from incremental databases. The paper provides a novel approach for mining high utility itemsets from dynamic databases and presents several experiments that demonstrate the effectiveness of the proposed approach.