bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional responses in a lizard along a 3.5‐km altitudinal gradient
Authors: Serén Nina , Megía‐Palma Rodrigo , Simčič Tatjana , Krofel Miha , Guarino Fabio Maria , Pinho Catarina , Žagar Anamarija , Carretero Miguel A. 
Published: September 2023

AbstractAimPhysiological and metabolic performance are key mediators of the functional response of species to environmental change. Few environments offer such a multifaceted array of stressors as high‐altitude habitats, which differ markedly in temperature, water availability, UV radiation and oxygen pressure compared to low‐altitude habitats. Species that inhabit large altitudinal gradients are thus excellent models to study how organisms respond to environmental variation.LocationTenerife island, Canary Islands archipelago (Spain).TaxonTenerife lizard (Gallotia galloti, Lacertidae).MethodsWe integrated data on age structure, thermal and hydric regulatory behaviour and four metabolic and stress‐related biomarkers for an insular lizard that inhabits an extreme altitudinal range (sea level to 3700 m a.s.l.), to understand how an ectotherms' age, ecophysiology and metabolism can be affected by extreme environmental variation.ResultsWe found marked differences in metabolic stress markers associated with altitude (particularly in the abundance of carbonyl metabolites and relative telomere length), but without a linear pattern along the altitudinal cline. Contrary to expectations, longer telomeres and lower carbonyl content were detected at the highest altitude, suggesting reduced stress in these populations. Evaporative water loss differed between populations but did not follow a linear altitudinal gradient. Lizard age structure or thermal physiological performance did not markedly change across different altitudes. Mixed signals in life‐history and thermal ecology across populations and altitude suggest complex responses to variable conditions across altitude in this species.Main ConclusionsOur integrative study of multiple functional traits demonstrated that adaptation to highly divergent environmental conditions in this lizard is potentially linked to an interplay between plasticity and local adaptation variably associated with different functional traits.
Triglyceride glucose index and renal function decline in Han Chinese hypertensive patients
Authors: Chen Hung‐Chang , Tsai Yun‐Hsuan , Huang Chin‐Chou 
Published: September 2023

AbstractElevated triglyceride glucose (TyG) index is associated with an increased risk of cardiovascular disease. The current study aimed to investigate whether the TyG index was correlated with renal function decline in patients with hypertension. Han Chinese participants with essential hypertension were included. The TyG index was calculated as ln[fasting triglycerides (mg/dL) * fasting glucose (mg/dL)/2]. Renal function decline was defined as >25% decline in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to examine the independent effect of the TyG index on renal events. In total, 548 Han Chinese hypertensive participants with a mean age of 62.1 ± 14.3 years were eligible for enrollment. During a mean follow‐up period of 4.7 ± 3.1 years, 97 patients suffered from >25% decline in eGFR. When compared to those without eGFR decline, patients with eGFR decline had higher fasting triglyceride levels (P = .056), fasting glucose levels (P = .014), and TyG indexes (P = .014). The Cox proportional hazard regression model revealed that the TyG index (hazard ratio [HR] = 1.490; 95% confidence interval [CI] = 1.016–2.185, P = .041), office systolic blood pressure (HR = 1.013; 95% CI = 1.000–1.026, P = .047), diabetes mellitus (HR = 1.797, 95% CI = 1.026–3.147, P = .040), and baseline eGFR (HR = 1.015; 95% CI = 1.002–1.028, P = .025) were associated with renal events. In conclusions, an elevated TyG index is independently associated with an increased risk of eGFR decline in hypertensive patients.
High BMP7 expression is associated with poor prognosis in ovarian cancer
Authors: Vasan Richa , Yadav Jahnavi , Aiyappa‐Maudsley Radhika , Deen Suha , Storr Sarah J. , Martin Stewart G. 
Published: September 2023

AbstractBone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor‐β (TGF‐ β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and may play an important role in the aggressiveness of the disease. However, the protein expression in patient tumours has not been well studied. The current study aimed to assess BMP7 protein expression in a large cohort of ovarian carcinoma patient tumour samples to establish its associations with different clinical endpoints. Ovarian carcinoma tissue samples from 575 patients who underwent surgery for different subtypes of ovarian cancer were used. BMP7 protein expression was analysed by immunohistochemistry using tissue microarray and full face tumour sections. High BMP7 expression is associated with aggressive ovarian cancer clinicopathological variables including advanced FIGO stage, high grade, residual disease and poor overall survival. Elevated cytoplasmic and nuclear BMP7 expression was significantly associated with advanced FIGO stage, high tumour grade, presence of residual tumours and high‐grade serous carcinomas (p = 0.001, 0.005, 0.004, <0.001 and p < 0.001, <0.001, 0.002, 0.001 respectively). Increased cytoplasmic and nuclear BMP7 expression was also significantly associated with an adverse overall survival (p = 0.001 and 0.046 respectively). The study highlights the potential of BMP7 as a prognostic tool and as a potential novel target for ovarian cancer therapies to limit disease progression.
Type 1 diabetes, COVID‐19 vaccines and short‐term safety: Subgroup analysis from the global COVAD study
Authors: Chatterjee Tulika , Ravichandran Naveen , Nair Narmadha , Gracia‐Ramos Abraham Edgar , Barman Bhupen , Sen Parikshit , Joshi Mrudula , Saha Sreoshy , Nune Arvind , Pande Arun Kumar R , Velikova Tsvetelina , Parodis Ioannis , Tan Ai Lyn , Shinjo Samuel Katsuyuki , Boro Hiya , Agarwal Vikas , Aggarwal Rohit , Gupta Latika ,   COVAD Study Group
Published: September 2023

AbstractAims/IntroductionCoronavirus disease 2019 (COVID‐19) vaccinations have been proven to be generally safe in healthy populations. However, the data on vaccine safety in patients with type 1 diabetes are scarce. This study aimed to evaluate the frequency and severity of short‐term (<7‐day) adverse vaccination events (AEs) and their risk factors among type 1 diabetes patients.Materials and MethodsThis study analyzed data from the COVID‐19 vaccination in Autoimmune Diseases (COVAD) survey database (May to December 2021; 110 collaborators, 94 countries), comparing <7‐day COVID‐19 vaccine AE among type 1 diabetes patients and healthy controls (HCs). Descriptive statistics; propensity score matching (1:4) using the variables age, sex and ethnicity; and multivariate analyses were carried out.ResultsThis study analyzed 5,480 completed survey responses. Of all responses, 5,408 were HCs, 72 were type 1 diabetes patients (43 females, 48.0% white European ancestry) and Pfizer was the most administered vaccine (39%). A total of 4,052 (73.9%) respondents had received two vaccine doses. Patients with type 1 diabetes had a comparable risk of injection site pain, minor and major vaccine AEs, as well as associated hospitalizations to HCs. However, type 1 diabetes patients had a higher risk of severe rashes (3% vs 0.4%, OR 8.0, 95% confidence interval 1.7–36), P = 0.007), although reassuringly, these were rare (n = 2 among type 1 diabetes patients).ConclusionsCOVID‐19 vaccination was safe and well tolerated in patients with type 1 diabetes with similar AE profiles compared with HCs, although severe rashes were more common in type 1 diabetes patients.
A novel protein‐based fruit fly trap in melon flies Bactrocera cucurbitae for effective pest control management
Authors: McCracken Andrew W. , Niazy Nurah , Turi Samu , Arya Vijeth , Kempraj Vivek , Morimoto Juliano 
Published: September 2023

AbstractAgriculture remains a major source of subsistence for local communities in India. However, agricultural yield can be strongly affected by agricultural pest outbreaks. This can result in economic losses for small‐scale farmers who already experience socio‐economic challenges, such as lack of appropriate infrastructure and subsides. Sophisticated pest management techniques (e.g. sterile insect technique) are less accessible to small farmers in developing countries, and therefore, alternative cost‐effective approaches for pest management are needed. Here, we report our findings of a 3‐year field trial (2018–2020) in India, which was designed to test for the potential effectiveness of a novel, slow‐release formulation protein‐based trap, compared to standard Cuelure traps against melon flies Bactrocera cucurbitae (Diptera: Tephritidae). Protein‐bait traps can attract flies from both sexes (as opposed to male‐only, chemical traps), bearing the potential to have a greater long‐term impact on pest populations by decreasing future reproductive potential of trapped individuals. We found that, despite uneven sampling efforts, Cuelure had overall higher trapping performance, while protein‐bait traps, despite trapping at lower efficiency, were equally effective for trapping males and females. Simulations with our field data revealed that protein‐bait traps can have an ‘inclusive’ advantage by trapping females and thereby preventing future individuals. Overall, our study highlights the potential benefits of using this alternative trapping technique to supplement pest management in developing countries.
Differential modulation of digestive enzymes and energy reserves at different times after feeding in juveniles of the marine estuarine‐dependent flatfish Paralichthys orbignyanus (Valenciennes, 1839)
Authors: Albanesi Camila Paula , Méndez Eugenia , Michiels María Soledad , Radonic Mariela , López Andrea , López‐Mañanes Alejandra A. 
Published: September 2023

AbstractIntegrative studies are lacking on the responses of digestive enzymes and energy reserves in conjunction with morphological traits at distinct postprandial times in marine estuarine‐dependent flatfishes of ecological and economic importance, such as Paralichthys orbignyanus. We determined total weight (TW), hepato‐somatic index (IH), activities of digestive enzymes in the intestine, and the concentration of energy reserves in the liver and the muscle at 0, 24, 72, and 360 h after feeding in juveniles of P. orbignyanus. Amylase activity decreased at 72 h (about 30%). Maltase, sucrose, and lipase activities reached peak at 24 h (67%, 600%, and 35%, respectively). Trypsin and aminopeptidase‐N activities at 24 and 72 h, respectively, were lower than those at t = 0 (53% and 30%). A peak increase in the concentration of glycogen and triglycerides in the liver (24 h) (86% and 89%, respectively) occurred. In muscle, glycogen and triglyceride concentrations were unchanged at 24 h and higher at 72 and 360 h (100% and 60%). No changes were found in TW, IH, free glucose in the liver and muscle, and protein in the liver. The protein concentration in the muscle sharply increased at 24 and 360 h after feeding (60%). The results indicate a distinct and specific response of central components of carbohydrate, lipid, and protein metabolism that could be adjustments at the biochemical level upon periods of irregular feeding and even of long‐term food deprivation inside coastal lagoons or estuaries. The distinct responses of digestive enzymes in the intestine and energy reserves in the liver and muscle suggest the differential modulation of tissue‐specific anabolic and catabolic pathways that would allow the maintenance of physical conditions.
Multi‐omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum
Authors: Zhao Dake , Zhang Ya , Ren Huanxing , Shi Yana , Dong Ding , Li Zonghang , Cui Guanghong , Shen Yong , Mou Zongmin , Kennelly Edward J. , Huang Luqi , Ruan Jue , Chen Suiyun , Yu Diqiu , Cun Yupeng 
Published: September 2023

AbstractDiterpenoid alkaloids (DAs) have been often utilized in clinical practice due to their analgesic and anti‐inflammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathway responsible for DA production remains unknown. In this study, we successfully assembled a high‐quality, pseudochromosome‐level genome of the DA‐rich species Aconitum vilmorinianum (A. vilmorinianum) (5.76 Gb). An A. vilmorinianum‐specific whole‐genome duplication event was discovered using comparative genomic analysis, which may aid in the evolution of the DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent‐kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origin of DAs in A. vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs.
Positive and negative intergroup contact in school andout‐of‐schoolcontexts: A longitudinal approach to spillover effects
Authors: Karataş Savaş , Eckstein Katharina , Noack Peter , Rubini Monica , Crocetti Elisabetta 
Published: September 2023

AbstractThis study aims to tackle positive and negative intergroup contact in school and out‐of‐school contexts to test whether a spillover effect (i.e., the extent to which experiences that individuals have in one context spill over into another) applies to intergroup contact. Participants were 984 adolescents (Mage = 14.66; 62.7% female; 24.8% ethnic minority). Results indicated that positive contact in school was related over time to higher positive contact in out‐of‐school contexts and vice versa (i.e.,valence consistent spillover effect). Positive contact in school was linked over time to lower negative contact in out‐of‐school contexts (i.e.,valence inconsistent spillover effect). Overall, this study provides novel insights into the transmission of adolescents' intergroup contact across socialization contexts by emphasizing the leading role of positive contact in schools.
Longitudinal course and outcome of social jetlag in adolescents: A 1‐year follow‐up study of the adolescent sleep health epidemiological cohorts
Authors: Tamura Norihisa , Okamura Kayoko 
Published: September 2023

SummaryThe discrepancy in sleep timing between weekdays and weekends – social jetlag (SJL) – is known to negatively affect student quality of life (QOL). However, the association between social jetlag and physical/mental QOL among adolescents and the precise effect of social jetlag on depressive symptoms and daytime sleepiness remains unknown. This study investigated the longitudinal course, risk factors, and effects of social jetlag, a circadian misalignment, in a school‐based cohort. The participants were 427 students (13.3 ± 0.6 years, 45.2% girls) from five junior high schools. We performed a baseline survey in 2019 and a 1‐year follow‐up survey in 2020. Depressive symptoms, QOL, and daytime sleepiness were assessed using the Birleson Depression Self‐Rating Scale for Children, Paediatric Quality of Life Inventory, and Paediatric Daytime Sleepiness Scale. In the baseline survey, 49.6% of the students reported SJL ≥1 h, and 17.1% reported SJL ≥2 h. Among them, 37.2% and 6.8% reported persistent SJL at follow‐up, respectively. New incidences of SJL ≥1 h were associated with older age, non‐attainment of menarche or voice changes, and longer duration of smartphone use, whereas its persistence was associated with a later chronotype. Persistence of SJL ≥1 h and ≥2 h predicted depressive symptoms and daytime sleepiness at follow‐up, whereas new incidences of SJL ≥2 h predicted lower QOL. In conclusion, social jetlag has a persistent course, and daytime functioning can deteriorate as social jetlag becomes chronic. Our findings suggest the need for intensive interventions for social jetlag among adolescents.
Food allergy—A holistic approach to dietary management. A joint EAACI Research & Outreach Committee and INDANA review
Authors: Skypala Isabel J. , Reese Imke , Durban Raquel , Hunter Hannah , Podesta Marcia , Chaddad Maria Cecília Cury , Santos Alexandra F. , Agache Ioana 
Published: September 2023

AbstractFollowing a diagnosis of IgE‐mediated food allergy, to secure the best outcome, the patient should receive individualized advice tailored to their specific needs, which considers the type and presentation of the food involved, level of exclusion required, risk of cross‐contamination and any variance required for age, ethnicity, financial issues, and lifestyle. Issues such as food labels “may contain” statements, and variation in the threshold of reaction and impact of cofactors should also be considered. Most important is the need to ensure that the diagnosis is robust, especially given the nutritional, psychological, and socioeconomic issues that can affect an individual with a diagnosis of food allergy. Unnecessary exclusion of one or more foods that have not triggered allergic reactions, especially in individuals with allergic comorbidities, can result in severe IgE‐mediated reactions on re‐exposure. Given that food allergies may change over time, the diagnosis should be reviewed, to determine whether resolution is likely, or new‐food triggers are reported. Regular assessment is vital, especially during childhood, to ensure reintroduction occurs at an appropriate time, thus enabling increased diversity of the diet and improvement in the quality of life. For some, an IgE‐mediated food allergy may necessitate the life‐long exclusion of foods, and for others, a food habitually eaten suddenly triggers an allergic reaction in adult life. People of all ages, ethnicities, and socioeconomic backgrounds deserve individual advice on the management of their food allergy to support a healthy diet and improve quality of life.
Effect of education regarding treatment guidelines for schizophrenia and depression on the treatment behavior of psychiatrists: A multicenter study
Authors: Hasegawa Naomi , Yasuda Yuka , Yasui‐Furukori Norio , Yamada Hisashi , Hori Hikaru , Ichihashi Kayo , Takaesu Yoshikazu , Iida Hitoshi , Muraoka Hiroyuki , Kodaka Fumitoshi , Iga Jun‐ichi , Hashimoto Naoki , Ogasawara Kazuyoshi , Ohi Kazutaka , Fukumoto Kentaro , Numata Shusuke , Tsuboi Takashi , Usami Masahide , Hishimoto Akitoyo , Furihata Ryuji , Kishimoto Taishiro , Nakamura Toshinori , Katsumoto Eiichi , Ochi Shinichiro , Nagasawa Tatsuya , Atake Kiyokazu , Kubota Chika , Komatsu Hiroshi , Yamagata Hirotaka , Ide Kenta , Takeshima Masahiro , Kido Mikio , Kikuchi Saya , Okada Tsuyoshi , Matsumoto Junya , Miura Kenichiro , Shimazu Taichi , Inada Ken , Watanabe Koichiro , Hashimoto Ryota 
Published: September 2023

AimThis study aims to examine the real‐world effectiveness of education regarding clinical guidelines for psychiatric disorders using ‘the Effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE)’ project.MethodsThe EGUIDE project is a nationwide prospective implementation study of two clinical practice guidelines, i.e., the Guideline for Pharmacological Therapy of Schizophrenia and the Treatment Guidelines for Major Depressive Disorders, in Japan. Between 2016 and 2019, 782 psychiatrists belonging to 176 hospitals with psychiatric wards participated in the project and attended lectures on clinical practice guidelines. The proportions of guideline‐recommended treatments in 7405 patients with schizophrenia and 3794 patients with major depressive disorder at participating hospitals were compared between patients under the care of psychiatrists participating in the project and those not participating in the project. Clinical and prescribing data on the patients discharged from April to September each year from participating hospitals of the project were also analyzed.ResultsThe proportions of three quality indicators (antipsychotic monotherapy regardless of whether other psychotropics medication, antipsychotic monotherapy without other psychotropics and no prescription of anxiolytics or hypnotics) for schizophrenia were higher among participating psychiatrists than among nonparticipating psychiatrists. As similar results were obtained in major depressive disorder, the effectiveness of the project for the dissemination of guideline‐recommended treatment has been replicated.ConclusionThis strategy of providing education regarding the clinical guidelines for psychiatric disorders was effective in improving the treatment‐related behavior of psychiatrists. The use of this education‐based strategy might contribute to resolving the mental health treatment gap.
Insulin‐like growth factor binding protein‐2 as a biomarker for lupus nephritis
Authors: Luong Phuong Thi , Nguyen Thuy Thi Dieu , Nguyen Ngoc Thi , Ngo Hang Thu , Nguyen Huy Ngoc , Pho Diep Hong , Nguyen Huong Thu 
Published: September 2023

AbstractBackgroundLupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus (SLE). The aim of this study was to identify serum insulin‐like growth factor binding protein‐2 (IGFBP‐2) as a novel non‐invasive biomarker for clinical disease and renal pathology in pediatric LN.MethodsA cross‐sectional study on 93 newly diagnosed LN children who were biopsy‐proven, 35 SLE children with no renal involvement as disease controls, and 30 healthy controls (HC) with age and gender‐matched. All children were ELISA tested for serum IGFBP‐2 levels. Clinical, laboratory, histopathological features of LN patients were collected.ResultsCompared to SLE or HC, serum IGFBP‐2 levels were significantly elevated in LN patients. Serum IGFBP‐2 could distinguish LN patients from two others (AUC = 0.937, p < 0.001 for LN vs. HC; 0.897, p < 0.0001 for LN vs. SLE). In ROC analysis, IGFBP‐2 had a higher ability to differentiate between LN and SLE than anti‐dsDNA with AUC values of 0.895 and 0.643, respectively. LN children with systemic lupus erythematosus disease activity index (SLEDAI) in high activity had significantly higher IGFBP‐2 concentration than the others with SLEDAI in moderate activity. Serum IGFBP‐2 correlated with albuminemia levels (r = 0.415, p < 0.001), urine protein‐to‐creatinine levels (r = 0.316, p = 0.002), estimated glomerular filtration rate (r = 0.438, p < 0.001), complement C3 (r = 0.333, p = 0.001). More importantly, serum IGFBP‐2 correlated with the activity index of renal pathology (r = 0.312, p = 0.007, n = 75).ConclusionsSerum IGFBP‐2 is a promising biomarker for pediatric lupus nephritis, reflective of disease activity and activity index in renal patients.
Kant on punishment and poverty
Authors: Hadsell Nicholas 
Published: September 2023

AbstractI offer a Kantian argument for the idea that the state lacks the authority to punish neglected, impoverished citizens when they commit crimes to cope with that neglect. Given Kant's own commitments to the value of external freedom and the state's obligation to ensure it, there is no reason a Kantian state can claim authority to punish an impoverished citizen while also failing in significant ways to protect her external freedom.