bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of prevalent Ciliophora, Discoba and Copepoda protists in deep sea water by in situ nucleotide extraction
Authors: Xu Peikuan , Yang Ming , Li Jun , Gao Zhaoming , He Lisheng , Jiang Yuelu , Wang Yong 
Published: July 2023

Abstract
Deep-sea eukaryotic microorganisms play an important role in degradation of deep-sea organic matter and geochemical cycle of various elements. However, whether sampling methods can affect detection of eukaryotic microbial community under high hydrostatic pressure in deep ocean remains a question. In this study, we compared traditional water sampling method using a Niskin bottle, an in situ microbial filtration and fixation method (ISMIFF) and a multiple in situ nucleic acid collection method (MISNAC) to exhibit differences in the community structures in the samples collected at ~ 590-3,100 m depths in the South China Sea (SCS). The MISNAC samples were separated into lysed cells on filtration membranes in a chamber and subsequent precipitated DNA attached on silica resin columns connected to the chamber. The classification and biodiversity indices of 18S rDNA Illumina sequencing reads from V9 variation region showed that the diversity of samples collected by MISNAC DNA absorption columns was much higher than that of other samples. More importantly, the relative abundance of Ciliophora, Copepoda and Diplonemea in the MISNAC adsorption column samples was significantly higher than that in the others, while Retaria were dominant in the MISNAC membrane samples. This indicates that MISNAC columns might in situ collect more DNA for the naked protists, while Retaria with a carbonate shell were more likely retained on the membrane. We therefore report a group of dominant protists in deep-sea water column, which have been missed by previous sampling methods probably due to environmental changes that may damage the naked protist cells.
P-ConvLSTM: An Effective Parallel ConvLSTM-based model for Short-term Electricity Load Forecasting
Authors: Kshetrimayum Nilakanta , Singh Khumukcham Robindro , Hoque Nazrul 
Published: July 2023

Abstract

Short-term Load Forecasting (STLF) is a challenging task for an Energy Management System (EMS) that depends on highly unpredictable and volatile factors, making it difficult to predict the electricity load demand accurately. Despite the challenges, it is an essential component, as it helps to ensure energy demand-supply equilibrium, prevents blackouts, reduces the need for expensive peak power generation, and improves the efficiency and reliability of the EMS. Motivated by these factors, we have proposed a novel STLF framework using a multi-input parallel ConvLSTM model. The effectiveness of the proposed model is verified using two publicly available load-series datasets. On the Malaysia dataset, the proposed model yields 998.12, 2.59%, 1590.34, and 0.987 for MAE, MAPE, RMSE, and R2, respectively. Similarly, on the Tetouan dataset, this model yields 1737.32, 2.49%, 2254.91, and 0.976 for MAE, MAPE, RMSE, and R2, respectively. These outperforming results found in the comparative experiments are further statistically verified using Friedman's test. The presenting framework of STLF can help EMS to make informed decisions about resource allocation and system operations.
Beliefs, Concerns, Attitudes and Adaptation Strategies of Farmers Towards Climate Change in Cagayan Valley, Philippines
Authors: Bassiag Flordeliza R. 
Published: July 2023

Abstract

The study aimed to determine the climate change beliefs, concerns, attitudes and adaptation practices or strategies of farmers in Cagayan Valley, Philippines.
A total of 205 farmers from lowland and upland were surveyed using a structured questionnaire. Based on the results, respondents believed that local water availability has decreased (96%) while summer temperature has increased (98%). The respondents are highly concerned about the various climate-related risks and future impacts of climate change on their farms. As to their local climate change sensitivity both global and local, they strongly agreed to the different statements.
Based on the statements on the practices of the respondents to the risks and effects of climate change on local water availability, they accounted that they “moderately likely” to adapt to it.
Likewise, statements on cropping practices as strategies to abate climate change risks and impacts in their farms were “moderately likely” to adapt by the respondents while for energy and efficiency adaptation strategies, they “unlikely” adapt to it.
There were a number of practices mentioned by the respondents that they adapted during prolonged drought and rainy periods. These were ranked accordingly. Generally, farmers are apt to adapt to the changes in climate conditions however, risks and impacts cannot be underestimated or left aside. The farmers need support from all concerned sectors for them to continue to produce more food amidst extreme conditions.
A systematic review and meta-analysis of prognostic indicators in patients with head and neck malignancy treated with immune checkpoint inhibitors
Authors: Kang Deng Xiong , liu Siping , Yuan Xin , Liu Shenxiang , Zhang Zhengrong , He Zhilian , Yin Xudong , Mao Haiyan 
Published: July 2023

Abstract
Introduction: Tumor immunotherapy has recently emerged as a crucial focal point in oncology treatment research. Among tumor immunotherapy approaches, tumor immune checkpoint inhibitors (ICIs) have attracted substantial attention in clinical research. However, this treatment modality has benefitted only a limited number of patients. We conducted a meta-analysis of various biomarkers to decipher their prognostic implications in patients with head and neck squamous cell carcinoma (HNSCC) who are treated with ICIs and thus identify predictive markers with practical clinical relevance.
Methods: A systematic search of electronic databases was conducted to identify clinical studies that examined the correlation between biomarkers and treatment outcomes in the HNSCC patients. The included articles were screened and analyzed to extract data regarding overall survival (OS), progression-free survival (PFS).
Results: The relationship between the biomarkers included in the summary and prognosis was as follows: HPV positivity was associated with improved OS (HR = 0.76, 95% CI = 0.58–1.99), PFS (HR = 1.16, 95% CI = 0.81–1.67), and response (OR = 1.67, 95% CI = 1.37–2.99). PD-L1 positivity was associated with OS (HR = 0.71, 95% CI = 0.59–0.85), PFS (HR = 0.56 95% CI = 0.43–0.73), and response (OR = 2.16, 95% CI = 1.51–3.10). Neither HPV positivity nor PD-L1 positivity was associated with DCR. The following markers were collected for OS and PFS data and were associated with longer OS: lower Glasgow prognostic score (GPS/mGPS) grading, lower PS grading, high body mass index (BMI), low neutrophil-to-lymphocyte ratio (NLR), low platelet-to-lymphocyte ratio (PLR), high albumin (Alb), low lactate dehydrogenase (LDH). Factors associated with better PFS were lower GPS/mGPS grading, lower PS grading, high BMI, low NLR, high absolute lymphocyte count, and low LDH. Hyperprogressive disease was associated with worse OS and PFS. Fewer clinical studies have been completed on the tumor microenvironment and hypoxia, microsatellite instability/DNA mismatch repair, and microbiome and systematic analysis is difficult.
Conclusions: In our meta-analysis, different immune checkpoint factors were associated with different prognoses in HNSCC patients receiving immunotherapy. HPV, PD-L1, BMI, Alb, HPD, PS, GPS/mGPS, LDH, NLR, and PLR predicted the ICI outcome in HNSCC patients.
Does charitable donation affect corporate environmental information disclosure? -- Moderating effect based on institutional investors' shareholding
Authors: song xinrong 
Published: July 2023

Abstract
In the context of ecological civilization construction, this paper takes China's Ashare listed companies from 2010 to 2021 as the research sample to study the impact of listed companies' charitable donations on environmental information disclosure, and analyzes the moderating role played by institutional investors. The results show that the larger the scale of charitable donation of listed companies is, the higher the level of environmental information disclosure is, and the improvement of non-monetary environmental information disclosure is more obvious, and there is a masking phenomenon. Institutional investors' shareholding has an inhibitory effect on the relationship between charitable donation and environmental information disclosure, and the inhibitory effect of pressure resistant institutional investors is more significant. Further research shows that the moderating effect of institutional investors is different in the internal and external characteristics of enterprises. Based on the internal characteristics of enterprises, the moderating effect of institutional investors is stronger in non-state-owned enterprises and heavy pollution industries. At the same time, it is found that in the external characteristics of enterprises, the inhibition effect of institutional investors on the positive correlation between charitable donation and environmental information disclosure quality is more obvious for enterprises with lower competition degree and enterprises located in the eastern or western regions.
Numerical Inference on the Weibull Distribution
Parameters Using Picard’s Method
Authors: Maswadah M. 
Published: July 2023

Abstract
Recently, numerical analysis has been used effectively for estimating the lifetime distribution parameters in the literature. Therefore, the main objective of this paper is to introduce a new numerical estimation technique, such as Picard’s method. This method has been used to estimate the Weibull model parameters and compare them with the most common estimation method in statistical inference, which is the Bayes’ method based on the informative gamma and kernel priors, via Monte Carlo simulations. The simulation results indicated that Picard’s method outperformed Bayes’ method using different loss functions. Finally, two real data sets have been analyzed for illustrations and TO compare the proposed methods.
Dimorphic Fungal Infections in HIV/AIDS Patients with non-TB Chronic Cough at Mulago Hospital, Kampala, Uganda
Authors: Kiconco Prossy , Achan Beatrice , Najjingo Irene , Sanya Moses , Okeng Alfred , Binoga Winnie , Musinguzi Benson , Bwanga Freddie 
Published: July 2023

Abstract

Introduction:
Dimorphic fungi cause infection following inhalation of spores into the pulmonary system. In the lower respiratory tract, the conidia transform into the yeast phase which are engulfed by alveolar macrophages and may be destroyed without disease manifestation. However, in some cases they may persist and cause fungal disease characterized by formation of granulomas in the infected tissues, which may mimic MTB.
Objective
To explore if dimorphic fungi play any role in pulmonary disease among XpertTB/RIF Negative HIV Patients with chronic cough attending ISS Clinic at Mulago hospital Uganda.
Methods
Sputum samples were collected from 175 consented HIV infected patients attending ISS Clinic. Upon Xpert/RIF test at ISS Clinic 21 of these tested positive, the 154 negative sputum samples were then subjected to PCR for dimorphic fungi at MBN Clinical Laboratories. Singleplex PCR using specific primers was used to detect a target sequency in the gene of each dimorphic fungi of interest, the resulting amplicons were electrophoresed on a 2% gel then visualized under UV light.
Results
Blastomyces dermatitidis and Tarolomyces marneffei were detected in 16.4% of the studied participants, with 9.1% and 7.1% respectively and 83.8% of the participant sample had no dimorphic fungi. Coccidiodes immitis, Paracoccidiodes brasiliensis and Histoplasma capsulatum were not detected in any of the participants
Conclusion
Dimorphic fungi play a role in pulmonary disease among the HIV/AIDS with non- TB chronic in Uganda.
Comparision of Romberg and Fixed Tolerance Gaussian Quadrature Over Complex Exponent Functions
Authors: Kumar Tanmay 
Published: July 2023

Abstract
This research paper presents an extensive comparative investigation of two numerical integration techniques: Romberg1and Fixed Tolerance Gaussian quadrature,2 when applied to functions with complex exponents. The main objective is to evaluate the accuracy and efficiency of these methods in approximating definite integrals over functions with imaginary/complex powers. The study involves systematic analyses of the computational requirements and precision achieved by each method over multiple intervals. QUADPACK's3 adaptive quadrature is utilized as a benchmark. Through this study, valuable insights are offered into the performance of these quadrature techniques when dealing with integrals involving complex exponents.
Bioinformatic analysis of a MALDI-TOF in-house library of viral and cell cultures. Understanding strengths and limitations.
Authors: Martin Gabriel , Alba Jose María González , Ochoa Cristina , Martínez Zulema Pérez , Boga Jose Antonio , Melón Santiago , Alba Susana Rojo , Argüelles Marta Elena Álvarez 
Published: July 2023

Abstract
The use of the MALDI-TOF system for viral identification is a technique that continues on the development stage, and it advances above all to the research and development of in-house libraries.
In this work, we analyse by two different bioinformatics tools our own in-house library of viral and no-infected cell cultures, performing a clustering analysis and two different marker discovery assays, that lead as to the detection, first, of the limitations to differentiate cultures and to the discovery of different unique markers for the recognition of HSV and ADV cultures.
Functionalized Morpholine-thiazole Scaffold: Synthetic Strategies and
Applications
Authors: Ali Tarik E. , Assiri Mohammed A. , Alqahtani Maha N. 
Published: July 2023

Abstract:
The thiazole derivatives as important members of heterocyclic compounds have attracted much synthetic interest due to their different biological properties. In recent years, studies on the syn-thesis of morpholine compounds have increased because of the properties of this core. In particular, the hybrid structures in which the thiazole ring is linked to morpholine nuclei in one molecular frame have gained popularity. The presented review is an attempt to summarize a huge volume of data on morpholinothiazoles being a widely studied class of these molecules used in modern organic and me-dicinal chemistry. The manuscript covers the approaches to the synthesis of the morpholinothiazoles derivatives. The synthetic strategies of the target compounds depend on one-pot or multistage reac-tions or the transformation of other related heterocycles. Additionally, we covered the biological ac-tivities and other applications of certain morpholinothiazoles. The information on these compounds made special consideration of medicinal chemists to yield a combinatorial library and carry out thor-ough efforts in the search of morpholinothiazoles.
Nutritional and Herbal Supplements for Weight Loss Management:
A Review
Authors: Nannar Ajay R. , Shendge Raosaheb S. , Salunkhe Kishor S. 
Published: July 2023

Abstract:
Millions of dollars have been spent on nutritional and herbal supplements, which are
used by many overweight people to lose weight. However, there are concerns about the effectiveness
and safety of several supplements. By boosting energy expenditure, satiety, fat oxidation, inhibiting
dietary fat absorption, moderating carbohydrate metabolism, raising fat excretion, increasing
water elimination, and improving mood, supplements are thought to aid in weight reduction.
This study provides an overview of the present status of the research on a few particular dietary
supplements, herbal combinations, and combination products, as this field is evolving quickly.
More studies on numerous supplements are required to verify their efficacy because they have not
been examined in randomised controlled trials. Nutritionists and medical experts should go through
dietary supplement use with patients and notify the FDA of any negative side effects. Additional
rules would be required for the manufacture, sale, and marketing of these supplements.
Nontuberculous Mycobacterial Infection Mimicking Lung Cancer in a Patient
with Usual Interstitial Pneumonia Pattern Interstitial Lung Disease: A Case
Report
Authors: Lee Chaebin , Park Jongsoo , Lim Jae-Kwang , Park Jongmin , Park Byunggeon 
Published: July 2023

Background:
It has been reported that structure damage in the parenchymal lung disease such as idiopathic pulmonary fibrosis (IPF) is associated with high susceptibility to nontuberculous mycobacterial (NTM) infection. Radiologic features of NTM lung disease in destructive lung parenchyma can be atypical, which can cause confusion with other diseases including malignancy. Prompt and accurate identification of newly developed lesions in the follow-up computed tomography (CT) of IPF patients is challenging but crucial.

Case Report:
We reported a case of an NTM infection in a patient with IPF, manifested as a mass-like consolidation with cavitation on chest CT, mimicking lung cancer.

Conclusion:
Being aware of the unusual radiologic features of NTM lung disease in IPF patients can be useful in the differential diagnosis of newly detected lesions.
Tizanidine Induced Hypotension: Report of a Case and Review of the
Literature
Authors: Mahajan Roopali , Kalita Jayantee 
Published: July 2023

Introduction:
Spasticity is a common sequelae of stroke, and often these patients receive
anti-spastic drugs such as baclofen or tizanidine. Stroke patients have multiple co-morbidities
such as hypertension, diabetes, and seizure. Tizanidine is an α2 and imidazole receptor agonist at a
spinal and supraspinal level resulting in reduced central sympathetic outflow and causing hypotension
rarely, especially in those receiving beta-blockers or angiotensin-converting enzyme inhibitors.

Case Presentation:
We report a 56-year-old hypertensive male presenting with altered sensorium
who had recurrent intracerebral hemorrhage with left spastic hemiplegia and focal seizures.
He was on amlodipine, atenolol, telmisartan and oxcarbazepine. After 3 doses of tizanidine 2mg,
his blood pressure dropped from 140/90 to 80/40 mmHg and pulse from 82 bpm to 44 bpm. His
blood counts, serum chemistry, procalcitonin, and Trop I were normal. ECG revealed sinus
bradycardia. After 8 hours of withdrawing tizanidine, his blood pressure became 110/70 mmHg,
and on the next day, it became 140/82 mmHg. His attendants were taught physiotherapy to minimize
spasticity.

Conclusion:
This patient highlights the need for close monitoring of patients receiving tizanidine
co-medication with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers.
These drugs have a synergistic effect on reducing the renin-angiotensin-aldosterone system, thereby
hypotension and bradycardia.
Study of the Analgesic Potential of the Ethanolic Extract of Moroccan
Cistus ladanifer L.
Authors: Adadi Imad , Ayadi Rachida El , Hajji Lhoussain , Eddouks Mohamed , Ibaoui Hamid El 
Published: July 2023

Aims:
The study aimed to analyze the analgesic activity of Cistus ladanifer L.

Background:
Cistus ladanifer L. is a fragrant shrub of the Cistaceae family widespread in the Mediterranean
basin, it has various biological activities, including antidiabetic and antihypertensive effects.

Objective:
The objective of this work was to study the phytochemical profile, the acute toxicity and
the analgesic power of the ethanolic extract of the species Cistus ladanifer L. (C. ladanifer) collected
in Northern Morocco.

Methods:
The evaluation of antinociceptive activity in mice was performed using two validated
models, the formalin-induced paw-licking model and the acetic acid-provoked writhing test.

Results:
According to the results, five phenolic compounds were identified in the ethanolic extract
by HPLC-MS/MS. As regards the acute toxicity study, the results showed no mortality or clinical
symptoms in mice treated to compare the control group at doses up to 5,000 mg/kg BW. Regarding
the analgesic effect, the ethanolic extract at the doses of 400 and 800 mg/kg, BW showed a statistically
significant (p <0.05) and dose-dependent analgesic effect in two nociceptive tests. On the other
hand, in the syrup of ethanolic extract at the dose of 800 mg/kg, BW expressed the most superior
pain-inhibiting effect in both tests, producing an analgesic effect equivalent to that of the reference
drug (indomethacin).

Conclusion:
These findings provide pharmacological justification that might aid in the development
of a natural anti-nociceptive medication as an alternative to chemical analgesic drugs.
Research on Typical Fault Diagnosis of Gear based on GHM Multiwavelet
Transform and MCKD Algorithm
Authors: Zhang Hongxin , Ji Zhongshu , Song Ruijin 
Published: July 2023

Background:
Gear is the key part of the transmission part of mechanical equipment, which has a high failure rate under complex working conditions or long-term operation, directly affecting the reliability of mechanical equipment. To realize online monitoring of gears and predict gear faults, whether the diagnosis of typical gear faults is accurate and timely is a key link, so it is necessary to study the diagnosis of typical gear faults.

Objective:
This paper aims to propose a method that can effectively diagnose typical faults of gears and is easy to program, which is beneficial to realize online monitoring of rotating machinery equipment faults.

Method:
A typical gear fault diagnosis method based on GHM multiwavelet transform and maximum correlation kurtosis deconvolution algorithm (MCKD) is proposed in this paper. The measured vibration signal is decomposed into components with multiple scale spaces and frequency bands through the GHM multiwavelet transform. Then, the MCKD algorithm is run to suppress the noise of GHM multiwavelet transform coefficients, and the periodic components containing fault information are retained and reconstructed. The typical faults such as gear pitting and broken teeth are tested.

Results:
GHM multiwavelet transform combined with MCKD algorithm can accurately locate the frequency band containing fault information from the vibration signal with multiple modulations, double sideband, and multi-frequency interference and effectively extract the fault frequency and its frequency multiplication. The root means a square error of the extracted fault frequency is 0.08. This method has a good noise suppression effect and high accuracy in extracting fault frequency.

Conclusion:
The method proposed in this paper is helpful in realizing automatic programming of gear fault diagnosis and is of great significance in realizing real-time monitoring and online diagnosis of rotating machinery equipment faults. More related patents will appear in the future.