bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of date seed powder supplementation on glycaemic markers and lipid profile in women with overweight and obesity: a randomised controlled trial
Authors: Hashemzadeh Maral , Shojaei‐Zarghani Sara , Heidarian Miri Hamid , Kazemi Asma 
Published: March 2023

SummaryThis randomised controlled trial aimed to investigate the effect of date kernel on glycaemic control, lipid profile, and weight in women with overweight and obesity. A total of 124 women with overweight or obesity were randomly assigned to receive the date kernel supplement or placebo for 12 weeks. Haemoglobin A1c (HbA1c) was measured by high‐performance liquid chromatography and fasting plasma glucose and lipid profiles by enzyme‐linked immunosorbent assay kits. In all, 98 subjects aged 40.7 years completed the trial (48 in the date kernel group and 50 in the placebo group). After 12 weeks, date kernel supplementation resulted in a significant decrease in HbA1c [mean (SD): −0.45 (0.36)] and fasting plasma glucose compared to the placebo [−0.16 (0.27)]. No significant change was observed in the lipid profiles of the total participants. However, date kernel decreased cholesterol and triglyceride (TG) in hypercholesterolaemic and hypertriglyceridaemic participants compared to the placebo. Date kernel improved glycaemic markers in overweight or obese women compared with the placebo. Furthermore, a significant reduction in total cholesterol and TG was observed only in hyperlipidaemic subjects. Date seed is a source of valuable components, including dietary fibre and bioactive compounds, that could provide economic, nutritional, and health benefits to the nutraceutical and food industries.
Action collective, action de mouvement social: la contribution du syndicalisme à la liberté au travail dans un exemple néo‐zélandais
Authors: PARKER Jane , ALAKAVUKLAR Ozan 
Published: March 2023

RésuméLes syndicats peuvent contribuer à la liberté au travail par une action collective axée sur l'intérêt des membres, mais aussi en nouant des partenariats avec d'autres acteurs de la société civile, dans le cadre d'un mouvement social. Pour traiter ce dernier aspect, encore peu documenté, les auteurs s'appuient sur les définitions de la liberté de Berlin (1988) et MacCallum (1967) puis sur la théorie de la démocratie radicale de Laclau et Mouffe (2019). Ils illustrent leur propos par une étude de cas portant sur les stratégies déployées par des syndicats néozélandais en vue d'accompagner l'action officielle pour une transition juste face au défi climatique.
Human fetal T cells: Insights into developmental specialization and mechanisms of lineage transition
Authors: Burt Trevor D. , McCune Joseph M. 
Published: March 2023

SummaryThe switch from primitive to definitive hematopoiesis occurs early in development through the emergence of a wave of definitive hematopoietic stem cells from intraembryonic sites, supplanting the original primitive population of extraembryonically derived stem cells. When it became clear that unique features of the fetal immune system could not be reproduced by adult stem cells, it was hypothesized that a lineage of definitive fetal hematopoietic stem cells predominates antenatally, ultimately giving way to an emerging wave of adult stem cells and resulting in a “layered” fetal immune system consisting of overlapping lineages. It is now clear, however, that the transition from human fetal‐to‐adult T cell identity and function does not occur due to a binary switch between distinct fetal and adult lineages. Rather, recent evidence from single cell analysis suggests that during the latter half of fetal development a gradual, progressive transition occurs at the level of hematopoietic stem‐progenitor cells (HSPCs) which is reflected in their T cell progeny. At a transcriptional level, clusters of genes are up‐ and down‐regulated with sequenced timing, suggesting that the transition is under the control of master regulatory factors, including epigenetic modifiers. The net effect is still one of “molecular layering,” that is, the continuous layering of iterative generations of HSPCs and T cells that arise through progressive changes in gene expression. This review will focus on recent discoveries that elucidate mechanisms of fetal T cell function and the transition from fetal to adult identity. The epigenetic landscape of fetal T cells facilitates their ability to fulfill the dominant fetal mandate of generating tolerance against self, maternal, and environmental antigens by supporting their predisposition to differentiate into CD25+FoxP3+ regulatory T cells (TRegs). We will explore how the coordinated development of two complementary populations of fetal T cells—conventional T cells dominated by TRegs and tissue‐associated memory effector cells with innate‐like inflammatory potential—is crucial not only for maintaining intrauterine immune quiescence but also for facilitating an immune response that is appropriately tuned for the bombardment of antigen stimulation that happens at birth.
Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity
Authors: Safi Rémi , Sánchez‐Álvarez Miguel , Bosch Marta , Demangel Caroline , Parton Robert G. , Pol Albert 
Published: March 2023

SummaryMicrobes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they “hijack” LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein‐mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic “Achilles’ heel” of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front‐line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the ‘defensive‐LDs’ functioning as hubs of innate immunity.
Understanding developmental cascades and experience: Diversity matters
Authors: Oakes Lisa M. 
Published: March 2023

AbstractThis Presidential Address is aimed at considering how infant development can be understood in terms of developmental cascades. Adopting a developmental cascades approach may be especially useful for understanding development in infancy, when changes occur in multiple domains over relatively short time spans. Thinking about change in terms of developmental cascades highlights the role of the input in development, both in terms of how the input changes with development and in terms of how differences in the input lead to different developmental pathways. I reflect on how a developmental cascade perspective can help us understand the role of input and how development builds as the emergence and refinement of abilities changes the input and shapes the developmental pathways. Further, I emphasize that infants develop despite differences in the input, and that when studying infant development we should seriously consider the diversity of experience that infants encounter and how differences in experience (and input) shape the developmental cascade.
Surveillance of endemic coronaviruses during the COVID‐19 pandemic in Iran, 2021–2022
Authors: Karami Hassan , Sadeghi Kaveh , Zadheidar Sevrin , Saadatmand Fatemeh , Mirsalehi Negar , Ardestani Nima Hoveidi , Kalantari Shirin , Farahmand Mohammad , Yavarian Jila , Mokhtari‐Azad Talat 
Published: March 2023

AbstractBackgroundHuman coronaviruses (HCoVs) 229E, OC43, HKU1, and NL63 are common viruses that continuously circulate in the human population. Previous studies showed the circulation of HCoVs during the cold months in Iran. We studied the circulation of HCoVs during coronavirus disease 2019 (COVID‐19) pandemic to find the impact of pandemic on the circulation of these viruses.MethodsAs a cross‐sectional survey conducted during 2021 to 2022, of all throat swabs sent to Iran National Influenza Center from patients with severe acute respiratory infection, 590 samples were selected to test for HCoVs using one‐step real‐time RT‐PCR.ResultsOverall, 28 out of 590 (4.7%) tested samples were found to be positive for at least one HCoVs. HCoV‐OC43 was the most common (14/590 or 2.4%), followed by HCoV‐HKU1 (12/590 or 2%) and HCoV‐229E (4/590 or 0.6%), while HCoV‐NL63 was not detected. HCoVs were detected in patients of all ages and throughout the study period with peaks in the cold months of the year.ConclusionsOur multicenter survey provides insight into the low circulation of HCoVs during the COVID‐19 pandemic in Iran in 2021/2022. Hygiene habits and social distancing measures might have important role in decreasing of HCoVs transmission. We believe that surveillance studies are needed to track the pattern of HCoVs distributions and detect changes in the epidemiology of such viruses to set out strategies in order to timely control the future outbreaks of HCoVs throughout the nation.
Temperature‐induced magnetic compensation and negative magnetization in a cluster spin glass Gd2Co0.5Mn1.5O6 system
Authors: Li Canglong , Yang Wenqian , Zheng Shuangshuang , Barasa Godfrey Okumu , Wang Pei , Zhou Kexin , Bai Chunxu 
Published: March 2023

AbstractExperiments for orthorhombic double perovskite Gd2Co0.5Mn1.5O6 revealed intrinsic effects of magnetic compensation characterized by M(Tcomp) = 0 at Tcomp = 20 K and negative magnetization depicted by M(T) < 0 under positive magnetic fields, which were experimentally investigated by different protocols of direct current magnetization measurements. Compared to Gd2CoMnO6, the excessive ratio of Mn in Gd2Co0.5Mn1.5O6 promotes the antisite disorder and preferably generates magnetic clusters owing to the intrinsic inhomogeneity. The clusters exhibit spin glass (SG) properties as demonstrated by alternating current susceptibility and aging measurements. A possible physical mechanism for evolution of the spin configuration with temperature is proposed. The effects of magnetic compensation and negative magnetization are attributed to the negative exchange coupling among the abundant ferromagnetic clusters. The additional pinning force provided by the cluster SG is an essential factor to prevent the flipping of the spins from aligning with the applied magnetic field.
Effect of the Diabetic Nephropathy Aggravation Prevention Program on medical visit behavior in individuals under the municipal national health insurance
Authors: Ikeda Asuka , Fujii Makoto , Ohno Yuko , Godai Kayo , Li Yaya , Nakamura Yuko , Yabe Daisuke , Tsushita Kazuyo , Kashihara Naoki , Kamide Kei , Kabayama Mai 
Published: March 2023

ABSTRACTAims/IntroductionWe aimed to clarify the effectiveness of the Diabetic Nephropathy Aggravation Prevention Program in Japan by comparing the diabetes‐related medical visit behavior of individuals under the municipal national health insurance according to insurers' effort levels.Materials and MethodsWe assessed changes in medical visit behavior according to insurers' effort levels, “Full Efforts,” “Some Efforts” and “No Effort,” using longitudinal data from the National Database of Health Insurance Claims and Specific Health Checkups before 2015 and after 2018 regarding the national health insurance programs in Japan. We analyzed the effect of the Diabetic Nephropathy Aggravation Prevention Program using a generalized linear mixed model for 208,388 participants with diabetes.ResultsThe additive effect on medical visit behavior was significantly higher for insurers with “Full Efforts” than for those with “No Effort;” the coefficient (log odds ratio) was 0.159 (95% confidence interval 0.063–0.256). The additive effects on medical visit behavior sizes for the people with hemoglobin A1c ≥7.0%, positive urinary protein and systolic blood pressure ≥140 mmHg were 0.508, 0.402 and 0.232, respectively, which were larger than the overall effect size (0.159) for insurers with “Full Efforts.”ConclusionsOur findings showed that insurer efforts had an additive effect on the increase in the number of medical visits, suggesting that this national program could reduce the number of end‐stage renal failures or dialysis in Japan.
Genomic convergence underlying high‐altitude adaptation in alpine plants
Authors: Zhang Xu , Kuang Tianhui , Dong Wenlin , Qian Zhihao , Zhang Huajie , Landis Jacob B. , Feng Tao , Li Lijuan , Sun Yanxia , Huang Jinling , Deng Tao , Wang Hengchang , Sun Hang 
Published: March 2023

ABSTRACTEvolutionary convergence is one of the most striking examples of adaptation driven by natural selection. However, genomic evidence for convergent adaptation to extreme environments remains scarce. Here, we assembled reference genomes of two alpine plants,Saussurea obvallata(Asteraceae) andRheum alexandrae(Polygonaceae), with 37,938 and 61,463 annotated protein‐coding genes. By integrating an additional five alpine genomes, we elucidated genomic convergence underlying high‐altitude adaptation in alpine plants. Our results detected convergent contractions of disease‐resistance genes in alpine genomes, which might be an energy‐saving strategy for surviving in hostile environments with only a few pathogens present. We identified signatures of positive selection on a set of genes involved in reproduction and respiration (e.g.,MMD1, NBS1, andHPR), and revealed signatures of molecular convergence on genes involved in self‐incompatibility, cell wall modification, DNA repair and stress resistance, which may underlie adaptation to extreme cold, high ultraviolet radiation and hypoxia environments. Incorporating transcriptomic data, we further demonstrated that genes associated with cuticular wax and flavonoid biosynthetic pathways exhibit higher expression levels in leafy bracts, shedding light on the genetic mechanisms of the adaptive “greenhouse” morphology. Our integrative data provide novel insights into convergent evolution at a high‐taxonomic level, aiding in a deep understanding of genetic adaptation to complex environments.
Patient‐reported motor chemotherapy‐induced peripheral neuropathy impacts function in advanced colorectal cancer survivors receiving chemotherapy: A cross‐sectional study
Authors: Hsieh Chia‐Fen , Chan Ya‐Ning , Wu Chih‐Jung , Yen Li‐Yu , Chang Yu‐Chi , Wang Ya‐Jung 
Published: March 2023

AbstractAimsChemotherapy‐induced peripheral neuropathy limits cancer survivors' compliance with chemotherapy and impaired function. This study aimed to examine separate impacts of clinician‐assessed, patient‐reported sensory and motor chemotherapy‐induced peripheral neuropathy on physical/role function and functional interference in advanced colorectal cancer survivors receiving chemotherapy.MethodsA cross‐sectional, correlational design utilizing convenience sampling enrolled 75 stage III or IV colorectal cancer adults undergoing chemotherapy. Participants filled out the Patient Neurotoxicity Questionnaire, Identification Pain Questionnaire, and Peripheral Neuropathy Scale. Then, a trained research nurse conducted a brief neurological assessment using the Total Neuropathy Scale ‐ clinical version.ResultsThe prevalence of sensory and motor chemotherapy‐induced peripheral neuropathy was from 34.7% to 54.7% and from 16.0% to 17.3%, respectively. Further, 20% of participants suffered from neuropathic pain. A low correlation between clinician‐assessed and patient‐reported chemotherapy‐induced peripheral neuropathy was detected. The function was significantly impacted by patient‐reported motor chemotherapy‐induced peripheral neuropathy.ConclusionsThis study was superior in utilizing the brief and valid patient‐reported and clinician‐assessed tools to measure sensory and motor chemotherapy‐induced peripheral neuropathy. Moreover, the identification of patient‐reported motor symptoms has the largest influence on function in advanced colorectal cancer survivors. Nurses may use the brief and easily administered tools in clinical settings for effective screening and early detection of motor and sensory chemotherapy‐induced peripheral neuropathy to prevent functional decline in advanced colorectal cancer survivors. However, this study was still limited because of the cross‐sectional design, small sample size, sample heterogeneity, and recruiting participants from only one medical center.
Impact of standardized nursing terminologies on patient and organizational outcomes: A systematic review and meta‐analysis
Authors: Bertocchi Luca , Dante Angelo , La Cerra Carmen , Masotta Vittorio , Marcotullio Alessia , Jones Dorothy , Petrucci Cristina , Lancia Loreto 
Published: March 2023

AbstractAimsTo explore the impact of 12 American Nurses Association recognized standardized nursing terminologies (SNTs) on patient and organizational outcomes.BackgroundPrevious studies reported an effect of SNTs on outcomes, but no previous frameworks nor meta‐analyses were found.DesignSystematic review and meta‐analyses.Review MethodsPubMed, Scopus, CINAHL, and OpenGrey databases were last consulted in July 2021. All abstracts and full texts were screened independently by two researchers. The review included primary quantitative studies that reported an association between recognized SNTs and outcomes. Two reviewers independently assessed the risk of bias and certainty of evidence for each meta‐analyzed outcome using the “Grading of Recommendations, Assessment, Development and Evaluation” (GRADE) approach.ResultsFifty‐three reports were included. NANDA‐NIC‐NOC and Omaha System were the most frequently reported SNTs used in the studies. Risk of bias in randomized controlled trials and not‐randomized controlled trials ranged from high to unclear, this risk was low in cross‐sectional studies. The number of nursing diagnoses NANDA‐I moderately correlated with the intensive care unit length of stay (r = 0.38; 95% CI = 0.31–0.44). Using the Omaha System nurse‐led transitional care program showed a large increase in both knowledge (d = 1.21; 95% CI = 0.97–1.44) and self‐efficacy (d = 1.23; 95% CI = 0.97–1.48), while a reduction on the readmission rate (OR = 0.46; 95% CI = 0.09–0.83). Nursing diagnoses were found to be useful predictors for organizational (length of stay) and patients' outcomes (mortality, quality of life). The GRADE indicated that the certainty of evidence was rated from very low to low.ConclusionsStudies using SNTs demonstrated significant improvement and prediction power in several patients' and organizational outcomes. Further high‐quality research is required to increase the certainty of evidence of these relationships.Clinical relevanceSNTs should be considered by healthcare policymakers to improve nursing care and as essential reporting data about patient's nursing complexity to guide reimbursement criteria.
Neuropsychological evaluation of phenoconversion risk in REM sleep behaviour disorder: A scoping review
Authors: Fiamingo Giuseppe , Capittini Cristina , De Silvestri Annalisa , Rebuffi Chiara , Cerami Chiara , Arnaldi Dario , Terzaghi Michele 
Published: March 2023

SummaryThe objective of this study was to assess the role of cognitive evaluation in the prediction of phenoconversion in polysomnography‐confirmed idiopathic or isolated rapid eye movement sleep behaviour disorder, through a scoping review focussing on a longitudinal comprehensive neuropsychological assessment of patients with idiopathic REM sleep behaviour disorder. A literature search (2006–2022) yielded 1034 records, and 20 were selected for analysis. The sample included 899 patients from eight different cohorts and five countries. We extracted data on clinical evolution, mild cognitive impairment diagnosis, neuropsychological tests used, and classification of cognitive domains. Tests, cognitive domains, and mild cognitive impairment definitions were heterogeneous across the studies, precluding a meta‐analysis. Ten studies (50%) evaluated the presence of mild cognitive impairment; 14 studies (70%) grouped neuropsychological tests into between three (6 studies, 21.4%) and seven (1 study, 7.1%) cognitive domains. The most frequently used tests were semantic fluency, Stroop colour word test, trail making test A and B, digit span, Rey auditory verbal learning test, and Rey‐Osterrieth figure. All except digit span showed a role in predicting phenoconversion. The authors did not consistently assign tests to specific cognitive domains. In conclusion, we discuss methodological differences between the studies and highlight the need for a standardised framework for neuropsychological data acquisition and presentation, based on a multilevel approach covering test selection, domain assignment, and mild cognitive impairment diagnostic criteria.
Predicting the deterrence effect of tax audits. A machine learning approach
Authors: Rabasco Michele , Battiston Pietro 
Published: March 2023

AbstractWe apply machine learning methods to the prediction of deterrence effects of tax audits. Based on tax declarations data, we predict the increase in future income declarations after being targeted by an audit. We find that flexible models, such as classification trees and ensemble methods based on them, outperform penalized linear models such as Lasso and ridge regression in predicting taxpayers more likely to increase their declarations after an audit. We show that despite the non‐randomness of audits, their specific time structure and the distribution of changes in declared amounts suggest a causal interpretation of our results; that is, our approach detects a heterogeneity in the reaction to a tax audit, rather than just forecasting an unconditional future increase. We find that taxpayers identified by our model will on average increase their declared income by €14,461—the average among all audited taxpayers being €−205. Our approach allows the tax agency to yield significantly larger revenues by appropriately targeting tax audit.
Assessing the effect of real estate market and renewable energy on environmental quality in Belgium
Authors: Samour Ahmed , Onwe Joshua Chukwuma , Inuwa Nasiru , Imran Muhammad , Ifelunini Innocent Abanum , Fulu Obonetse 
Published: March 2023

AbstractThe current research aims to study the influence of the real estate market and renewable energy on ecological quality in Belgium from 1990 to 2018. The recent study is quite different from the previous empirical literature on environmental quality; it introduces a new discourse on the determinant of environmental quality followed by Belgium's real estate market. This work employed a more robust and advanced econometric technique, that is, the ARDL bootstrap method, to estimate the relationship between the study variables. The empirical findings from the ARDL stimulation revealed that real estate negatively impacts environmental quality in Belgium in the short and long‐run periods. The policy implications emanating from the findings suggest that the real estate sector can significantly promote environmental quality by adopting and using renewable energy in construction, design, and buildings. Subsequently, this will reduce waste, energy and carbon emissions within the environment and prioritise using safer and sustainable green‐enabled material for real estate development. Again to ensure regulation in the real estate market so that tax revenue generated through real estate would be channelled towards building clean and smart cities, also, ecological and regulatory control should be enforced in the real estate market to foresee the possible reduction in environmental pollution through pollution, this measure will guarantee a green real estate investment that will lead to a sustained environment.