bluuebunny/crossref_metadata_2025_split huggingface dataset:
Installed performance seeking control based on supersonic variable inlet/engine coupling model
Authors: Wang Chen , Sun Ximing , Du Xian 
Published: April 2023

Abstract
With the advancement of the supersonic aero propulsion system, optimizing the combined performance of inlet/engine integration has become increasingly crucial. To solve the coupling inlet/engine problem, a quasi-one-dimensional inlet modeling and drag calculation method are proposed, integrated performance seeking control (PSC) based on the neighborhood-based speciation differential evolution-grey wolf optimizer (NSDE-GWO) is presented and quantitatively analyses the influence of variable geometry inlet regulation on performance. The results reveal that the optimization effect of the ramp angle adjustment is generally better than that of the bleed adjustment, and the NSDE-GWO hybrid algorithm achieves remarkable optimization solutions in all three different modes. The PSC with variable geometry inlet adjustment provides more additional potential for optimization compared with fixed geometry inlet, and the performance can be maximized by adjusting both the bleed adjustment and the ramp angle. This study maximizes the exploitation of potential and has theoretical guidance and practical engineering significance.
Fabrikumzüge im Rahmen von Reorganisationsprojekten
Authors: Nitsche Andreas , Stonis Malte , Nyhuis Peter 
Published: April 2023

Abstract
Die Realisierung eines geplanten Layoutkonzepts stellt eine komplexe Teilaufgabe innerhalb der Fabrikplanung dar. Insbesondere die zeitliche Anordnung der notwendigen Umzugsschritte unter Berücksichtigung vorhandener Restriktionen wird nach aktuellem Stand meist manuell ausgeführt. Eine methodische Planungsunterstützung könnte zu einer entscheidenden Reduzierung des Aufwands der Realisierungsvorbereitung beitragen. Daher wurde in einem Forschungsprojekt eine einfach anwendbare Methode zur Planung eines Fabrikumzugs für Reorganisationsprojekte entwickelt, welche von Unternehmen im praktischen Kontext angewendet werden kann.
ISAK: Ein flexibler Ansatz zur Optimierung von Prozessen in KMU
Authors: Stratidis Rafail , Marques-Fernandes Lygia , Zürn Siegfried 
Published: April 2023

Abstract
Das dynamische Umfeld, in dem Unternehmen heute agieren, sowie die rasante Entwicklung von neuen Technologien stellen Unternehmen vor große Herausforderungen. Es bedarf einer hohen Prozessflexibilität, um schnell auf neue Situationen und unerwartete Einflüsse reagieren zu können. Oftmals sind die in der wissenschaftlichen Literatur beschriebenen und von großen Unternehmen erfolgreich eingesetzten Methoden jedoch für KMU zu aufwändig. Hier setzt der einfach umzusetzende und sehr praxisorientierte ISAK-Ansatz an.
Cryo‐EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit
Authors: Liu Wei , Wang Jiening , Comte‐Miserez Véronique , Zhang Mengyu , Yu Xuejing , Chen Qingfeng , Jessen Henning Jacob , Mayer Andreas , Wu Shan , Ye Sheng 
Published: April 2023

AbstractThe eukaryotic vacuolar transporter chaperone (VTC) complex acts as a polyphosphate (polyP) polymerase that synthesizes polyP from adenosine triphosphate (ATP) and translocates polyP across the vacuolar membrane to maintain an intracellular phosphate (Pi) homeostasis. To discover how the VTC complex performs its function, we determined a cryo‐electron microscopy structure of an endogenous VTC complex (Vtc4/Vtc3/Vtc1) purified from Saccharomyces cerevisiae at 3.1 Å resolution. The structure reveals a heteropentameric architecture of one Vtc4, one Vtc3, and three Vtc1 subunits. The transmembrane region forms a polyP‐selective channel, likely adopting a resting state conformation, in which a latch‐like, horizontal helix of Vtc4 limits the entrance. The catalytic Vtc4 central domain is located on top of the pseudo‐symmetric polyP channel, creating a strongly electropositive pathway for nascent polyP that can couple synthesis to translocation. The SPX domain of the catalytic Vtc4 subunit positively regulates polyP synthesis by the VTC complex. The noncatalytic Vtc3 regulates VTC through a phosphorylatable loop. Our findings, along with the functional data, allow us to propose a mechanism of polyP channel gating and VTC complex activation.
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Authors: Wong Samantha , Tan Yu Xuan , Loh Abigail Yi Ting , Tan Kiat Yi , Lee Hane , Aziz Zainab , Nelson Stanley F , Özkan Engin , Kayserili Hülya , Escande‐Beillard Nathalie , Reversade Bruno 
Published: April 2023

AbstractSomatic and germline gain‐of‐function point mutations in RAF, one of the first oncogenes to be discovered in humans, delineate a group of tumor‐prone syndromes known as the RASopathies. In this study, we document the first human phenotype resulting from the germline loss‐of‐function of the proto‐oncogene RAF1 (a.k.a. CRAF). In a consanguineous family, we uncovered a homozygous p.Thr543Met variant segregating with a neonatal lethal syndrome with cutaneous, craniofacial, cardiac, and limb anomalies. Structure‐based prediction and functional tests using human knock‐in cells showed that threonine 543 is essential to: (i) ensure RAF1's stability and phosphorylation, (ii) maintain its kinase activity toward substrates of the MAPK pathway, and (iii) protect from stress‐induced apoptosis mediated by ASK1. In Xenopus embryos, mutant RAF1T543M failed to phenocopy the effects of normal and overactive FGF/MAPK signaling, confirming its hypomorphic activity. Collectively, our data disclose the genetic and molecular etiology of a novel lethal syndrome with progeroid features, highlighting the importance of RTK signaling for human development and homeostasis.
Hair Care in the Light of Selected Medieval Medical Treatises
Authors: Lisowska Karolina 
Published: April 2023

In the Middle Ages, hair was an element of great interest to men and women. Subject to daily treatments and activities, they played an important role in everyone‘s life. In medical treatises, compendia and handbooks from the 12th to the 14th century were the subjects of theoretical considerations and practical advice. According to the prevailing humoral theory, their colour, length, shape, and loss or excessive growth were meticulously analysed and explained. Attention was drawn to the issue of hair dyeing and the possibility of changing the colour. Particular attention was paid to baldness and greying, giving practical advice and simple or more complex recipes to prevent these processes. The source base is the works of St. Hildegard of Bingen, pope John XXI, Vincent of Beauvais, Taddeo Alderotti and Bernard de Gordon. In these sawmills, the issue of hair was highlighted, which in the Middle Ages played a significant role in the lives of both women and men.
Phenolic compounds from knema pachycarpa leaves
Authors: Le Nguyen Thanh  , Tran Huu Giap  , Vu Thi Hue  , Diep Thi Lan Phuong  , Nguyen Thi Hue  , Nguyen Hoang Nam  , Nguyen Quoc Vuong  
Published: April 2023

Knema (Myristicaceae family) is a large genus, comprising over 100 species found in of South East Asian countries, among that over 10 species was found in Vietnam. Knema pachycarpa is a native tree distributed in central provinces of Viet Nam. Until now, only few chemical studies of Knema species in Viet Nam have been reported. Phytochemical study of Knema pachycarpa leaves led to the isolation of seven known compounds including six flavonoids 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2), (-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), and nicotiflorin (6), and a biphenyl compound 3,3',4,4'-tetrahydroxybiphenyl (7). Their structures were elucidated by MS and NMR data analysis and compared with those previously reported. Compounds 3 and 6-7 were found from Knema genus for the first time. In the cytotoxic assay, biphenyl compound (7) exhibited strong cytotoxicity to KB cancer cell line with IC50 value of 2.38 ± 0.11 mg/mL. Compound 7 also displayed showed activity against HepG2, Lu and MCF7 cancer cell lines with IC50 ranges from 18.25 ± 0.92 mg/mL to 35.56 ± 1.17 mg/mL, whereas flavonoids 1-6 were weakly active or inactive against tested cell lines.
Biological Evolution of Southeast Asian Carbonates, Based on Their Microfossil Content
Authors: Lunt Peter 
Published: April 2023

A new compilation of data suggests aragonitic coral reefs were already common in Southeast Asia by the mid-Oligocene. A gradual change from calcite to aragonite seas through the Oligocene and early Miocene appears to be related to a gradual expansion of the importance of scleractinia, along with green algae and mollusks, and an associated decline in the abundance of calcitic larger foraminifera. The larger foraminifera had been important rock-forming bioclasts in the early part of the early Miocene, but were a minor component of carbonate faunas by the end of the middle Miocene. This gradual decline in abundance included a few extinction events that reduced diversity, and these extinctions appear to correlate with periods of tectonic change.
The K-selection evolutionary pressure impacted carbonate facies, but foraminifera maintained their taxonomic diversity until the abrupt faunal extinctions. Changes in sea-surface temperature, or the regional change from seasonal to ever-wet climate, do not appear to have impacted larger foraminiferal diversity or caused extinctions, only modified their latitudinal range.
Some extinction events can be recognized across the whole Tethys Ocean, as can some of the times of tectonic activity and possible climate change. These correlations tentatively point to a link between large-scale changes in plate motion, oceanography, and foraminiferal extinctions. In contrast, the change from seasonal to ever-wet conditions around the Oligo–Miocene boundary around the South China Sea does not appear to have been caused by a wider tectonic event, and this event does not impact larger foraminifera diversity. A combined tectonic unconformity and mass extinction of larger foraminifera in middle middle Miocene times might have been due to the plate tectonic constriction of a throughflow between the Pacific and Indian Oceans.
Smartwater Synergy with Chemical EOR: Studying the Potential Synergy with Surfactants
Authors: Sofi Abdulkareem , Wang Jinxun , Salaün Mathieu , Rousseau David , Morvan Mikel , Ayirala Subhash C. 
Published: April 2023

Summary
The potential synergy between smartwater and various enhanced oil recovery (EOR) processes has recently attracted significant attention. In previous work, we demonstrated such favorable synergy for polymer floods not only from a viscosity standpoint but also in terms of wettability. Recent studies suggest that smartwater synergy might even extend to surfactant floods. In this work, we investigate the potential synergy between smartwater and surfactant flooding. Opposed to previous work, the potential synergy is investigated from ground zero. We concurrently developed two surfactant formulations for conventional high-salinity injection water and low-salinity smartwater. To design the optimal surfactant-polymer (SP) formulations, we followed a systematic all-inclusive laboratory workflow. Oil displacement studies were performed in preserved core samples using the two developed formulations with conventional injection water and smartwater. The results demonstrated the promising potential of binary surfactant mixtures of olefin sulfonate (OS) and alkyl glyceryl ether sulfonate (AGES) for both waters. The designed binary formulations were able to form Winsor Type III emulsions besides achieving ultralow interfacial tensions (IFTs). Most importantly, in terms of oil displacement, the developed SP formulations in both injection water and low-salinity smartwater were capable of recovering more than 60% of the remaining oil post waterflooding. A key novelty of this work is that it investigates the potential synergy between smartwater and surfactant-based processes from the initial step of surfactant formulation design. Through well-designed from-scratch evaluation, we demonstrate that surfactant-based processes exhibit limited synergies with smartwater. Comparable processes in terms of performance can be designed for both high-salinity and low-salinity waters. It is also quite possible that the synergistic benefits of smartwater on oil recovery cannot be effective in SP flooding processes, especially with specific surfactant formulations under optimal salinity conditions.
Projection of Logging While Drilling Data at the Bit by Implementing Supervised Machine Learning Algorithm
Authors: Sharma Ashutosh , Burak Tunc , Nygaard Runar , Hellvik Svein , Hoel Espen , Welmer Morten 
Published: April 2023

Abstract
To analyze drilling performance a combination of Logging While Drilling data (LWD) and surface drilling data is combined. However, distance between some of the sensors, and the bit is greater than 20-30m (66-98 ft). In this case, determination of the LWD data at the bit becomes essential. This paper aims to implement machine learning algorithms to predict LWD data at the bit. The results of the model can be used to perform real-time analysis that considers the alterations in petrophysical properties, lithologies and rock strengths while drilling, without the drawbacks of LWD sensor offset.
The aim of the paper is to predict LWD data at the bit by evaluating which supervised machine learning algorithm to incorporate. For training and validation of the model, a dataset of high porosity formations from multiple wells located in the North Sea has been used. Dataset included gamma ray (GR) log data recorded near the bit and drilling parameters recorded at the bit. Multi-linear regression (MLR), K-nearest neighbor (KNN) regression, random forest (RF) regression and support vector machine (SVM) regression are used for model building. The most efficient model with the best coefficient of determination (R2) is selected.
The prediction forecasting for the random forest regression model was better among all the previously discussed regression models. The R2 value for the random forest regression model 98% and the KNN regression model came in second with R2 value at 95%. The worst performing regression model was the multi-linear regression model.
This machine learning approach to consider the LWD sensor offset can be useful in the determination of petrophysical properties at the bit and in the real-time drilling analysis.
Multi-Stage Heavy Pill Displacement Using Managed Pressure Tripping Technique in High Pressure-High Temperature Well with Narrow Drilling Margin - A Case Study in Haynesville Shale
Authors: Aliyev Fuad , Yousefi Sadat Ali , Cody Shawn , Huggard Brad , Dametz Sebastian 
Published: April 2023

Abstract
The narrow drilling window of a High Pressure-High Temperature (HPHT) formation creates challenges in managing bottom hole pressure (BHP) during drilling and tripping operations. Managed Pressure Drilling (MPD) techniques have proven effective in accurately controlling downhole pressure, especially in HPHT environments. This study evaluates the capability of automated Managed Pressure Tripping (MPT) techniques in the Haynesville shale gas. The results show that this approach effectively controls the BHP while tripping, resulting in significantly improved operational efficiency, cost, and safety.
MPD hydraulics are developed primarily based on the well profile, mud properties, and drill string dimensions. It uses analytical formulation to compute annular pressure losses along the wellbore every second. Subsequently, the required mud volume, pumping schedule, and applicable surface back pressures (SBP) for the displacement of the heavy pill are simulated to accurately follow the narrow drilling margin. This technique is provided to the field as guidance, and the heavy pill is displaced in multiple stages while maintaining constant bottom-hole pressure through MPD. This method is fully automated, given accurate drilling parameters, and can be controlled remotely from a remote operations center (ROC).
Drilling the deepest HPHT Haynesville wells with a narrow drilling window was successful by using MPD techniques with a mud weight of 16.0 ppg. The pore pressure / stability limit of 17.0 ppg was less than 2% of the formation integrity test (FIT) limit of 17.3 ppg. The MPD hydraulics simulator enables real-time BHP calculations, coupled with a pre-engineered mud schedule, which improves overall tripping efficiency. The heavy pill was displaced in multiple stages during casing and drilling BHA runs based on FIT results. This method resulted in smooth tripping procedures with no reported wellbore stability issues or fluid loss concerns. In comparison to conventional tripping, managing adequate SBP along with a mud pumping schedule allows tripping execution within such a narrow margin. There were no reported observations of wellbore stability issues nor any significant fluid loss concerns. In this case study, the well was drilled to a total depth of 24,100ft MD, and the production casing was successfully run to the planned depth using a multi-stage displacement technique.
Increasing Production by Using A 2-Stages Filtration System with a Gas Separator in Rod Pump
Authors: Vyas Shivani , Wadman Travis , Guanacas Luis , Gonzalez Gustavo 
Published: April 2023

Abstract
To deal with gas and sand problems in their conversion and rod pump wells an operator company in south Texas started introducing a combined technology of two-stages filtration with a modified poor boy gas separator obtaining excellent results. This paper explains the technology used and shares the information used to design the tools and the results achieved in the first wells completed. The screening process to choose the best technology started trying different technologies for gas and sand control below the rod pump. Different technologies were revised sharing data like sand particle size, pump design, fluid production expected and wellbore configuration to get the best design from different companies. The technical and economic evaluation determined the combined system with two-stages filtration and gas separation was the best technology among all the installations. After the results, same technology was applied to other wells changing the configuration based on the well conditions but maintaining the same principle of operation.
After the installation of this technology in each well, it was clear that there was a substantial increase in production among the wells that was caused for the improvement in the pump cards after the installation. The downhole equipment has been able to handle better gas production and no sand problems have been reported so far. The success of this technology has extended the operational capabilities of the pumps allowing the engineers to operate their wells better. Pump cards before and after the installations are summarized in the presentation to show evidence of the good results obtained. After the wells are converted from ESP to rod pump or when the gas represents an issue in the rod pumped wells, the production engineers are limited in the drawdown and the production they can get out of the wells. We are presenting an alternative for the operators to optimize the production's BHA and overcomsand and gas problems that limit the ability to increase the income of the oil fields.
Recommended Practice for Determining the Maximum Surface Injection Pressure for Saltwater Disposal Wells
Authors: Childers David R. , Wu Xingru Wu 
Published: April 2023

Abstract
As more and more water is being co-produced with hydrocarbon, saltwater management has become an important enterprise. Out of many available tools in water management, saltwater disposal through Type II wells is critical to handling large quantities of produced brine. Since the produced water usually contains impurities such as solids, oil and grease, and bacteria, the well's injectivity deteriorates over time as the skin factor develops. Injecting over the formation parting pressure (FPP) gradient may lead to a matrix bypass event and other geohazards; accurately determining the FPP of the target formation is needed to maintain safe injection operations. However, using the step rate test (SRT) doesn't warrant an accurate result. As the target formations can have multilayers with distinct properties, we often find that SRT is often misused.
SRT is often recommended based on oil field operational experience because it is easy to execute and interpret. One fundamental assumption for SRT is that the target formation is a single layer with relative isotropic properties; however, this isn't always true for saltwater disposal wells (SWDs), which usually penetrate through multilayers with very heterogeneous properties. To illustrate our concept, we present a case study using SRT results from an active SWD well located in the Anadarko Basin. We recommend a geomechanical model to determine the operating surface pressure in this paper. The geomechanical model considers the original stresses, variation of geomechanical parameters, injection pressure, and temperature. To consider the uncertainties of these parameters, we demonstrate how to use Monte Carlo simulation to determine the maximum operating surface pressure. We recommend several analyses for the collected data to determine the well's injectivity variation. The Monte Carlo simulation result yields a possible fracturing gradient and presents the probability of each fracturing gradient. Probability is crucial in decision-making as different operators/fields may have different risks, tolerance, and uncertainties. The recommended practice is an integration of data sets and analysis that yield the maximum injection pressure to maintain the well and formation integrity with different risk tolerance levels.