bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Model for the Tropical Cyclone Wind Field Response to Idealized Landfall
Authors: Chen Jie , Chavas Daniel R. 
Published: January 2023

Abstract
The impacts of a tropical cyclone after landfall depend not only on storm intensity but also on the size and structure of the wind field. Hence, a simple predictive model for the wind field after landfall has significant potential value. This work tests existing theory for wind structure and size over the ocean against idealized axisymmetric landfall experiments in which the surface beneath a mature storm is instantaneously dried and roughened individually or simultaneously. Structure theory captures the response of the low-level wind field to different types of idealized landfalls, given the intensity and size response. Storm size, modeled to follow the ratio of simulated time-dependent storm intensity to the Coriolis parameter , can generally predict the transient response of the storm gale wind radii r34kt to inland surface forcings, particularly for at least moderate surface roughening regardless of the level of drying. Given knowledge of the intensity evolution, the above results combine to yield a theoretical model that can predict the full tangential wind field response to idealized landfalls.

Significance Statement
A theoretical model that can predict the time-dependent wind field structure of landfalling tropical cyclones (TCs) with a small number of physical, observable input parameters is essential for mitigating hazards and allocating public resources. This work provides a first-order prediction of storm size and structure after landfall, which can be combined with existing intensity predictions to form a simple model describing the inland wind field evolution. Results show its potential utility for modeling idealized inland TC wind fields.
The Impacts of Interannual Climate Variability on the Declining Trend in Terrestrial Water Storage over the Tigris–Euphrates River Basin
Authors: Chang Li-Ling , Niu Guo-Yue 
Published: January 2023

Abstract
The Tigris–Euphrates dryland river basin has experienced a declining trend in terrestrial water storage (TWS) from April 2002 to June 2017. Using satellite observations and a process-based land surface model, we find that climate variations and direct human interventions explain ∼61% (−0.57 mm month−1) and ∼39% (−0.36 mm month−1) of the negative trend, respectively. We further disaggregate the effects of climate variations and find that interannual climate variability contributes substantially (−0.27 mm month−1) to the negative TWS trend, slightly greater than the decadal climate change (−0.25 mm month−1). Interannual climate variability affects TWS mainly through the nonlinear relationship between monthly TWS dynamics and aridity. Slow recovery of TWS during short wetting periods does not compensate for rapid depletion of TWS through transpiration during prolonged drying periods. Despite enhanced water stress, the dryland ecosystems show slightly enhanced resilience to water stress through greater partitioning of evapotranspiration into transpiration and weak surface “greening” effects. However, the dryland ecosystems are vulnerable to drought impacts. The basin shows straining ecosystem functioning after experiencing a severe drought event. In addition, after the onset of the drought, the dryland ecosystem becomes more sensitive to variations in climate conditions.

Significance Statement
The purpose of the research is to better understand climate impacts on terrestrial water storage over dryland regions with declining water storage. In our study, we disaggregate three components of climate impacts, namely, decadal climate change, interannual variability, and intra-annual variability. We then use observational datasets and a process-based model to quantify their individual effects on water storage. We find that interannual variability is the most significant climatic contributor to the declining water storage, mainly caused by prolonged drought periods and corresponding quick drying rates due to plant transpiration. We also find that the dryland ecosystem is sensitive and vulnerable to severe drought events. This study is important because 1) it provides a framework to investigate climate impacts on water fluxes and storages, 2) it highlights the importance of vegetation dynamics on dryland hydrology, and 3) it emphasizes the negative impacts of extreme hydroclimatological events on ecosystem functioning.
Land–Atmosphere Feedbacks Weaken the Cooling Effect of Soil Organic Matter Property toward Deep Soil on the Eastern Tibetan Plateau
Authors: Sun Jing , Yang Kun , Lu Hui , Zhou Xu , Li Xin , Chen Yingying , Guo Weidong , Wright Jonathon S. 
Published: January 2023

Abstract
Soil organic matter (SOM) is enriched on the eastern Tibetan Plateau, but its effects on the hydrothermal state of the coupled land–atmosphere system remain unclear. This study comprehensively investigates these effects during summer from multiple perspectives based on regional climate modeling, land surface modeling, and observations. Using a regional climate model, we show that accounting for SOM effects lowers cold and wet biases in simulations of this region. SOM increases 2-m air temperature, decreases 2-m specific/relative humidity, and reduces precipitation in coupled simulations. Inclusion of SOM also warms the shallow soil while cooling the deep soil, which may help to preserve frozen soil in this region. This cooling effect is captured by both observations and offline land surface simulations, but it is overestimated in the offline simulations due to no feedback from the atmosphere compared to the coupled ones. Including SOM in coupled climate models could therefore not only imrove their representations of atmospheric energy and water cycles, but also help to simulate the past, present, and future evolution of frozen soil with increased confidence and reliability. Note that these findings are from one regional climate model and do not apply to wetlands.

Significance Statement
The eastern Tibetan Plateau is rich in soil organic matter (SOM), which increases the amount of water the soil can hold while decreasing the rate at which heat moves through it. Although SOM is expected to preserve frozen soil by insulating it from atmospheric warming, researchers have not yet tested the effects of coupled land–atmosphere interactions on this relationship. Using a regional climate model, we show that SOM typically warms and dries the near-surface air, warms the shallow soil, and cools the deep soil by modifying both soil properties and energy exchanges at the land–atmosphere interface. The results suggest that the cooling effect of SOM on deep soil is overestimated when atmospheric feedbacks are excluded.
Real-Time Flood Forecasting via Parameter Regionalization and Blending Nowcasts with NWP Forecasts over the Jiao River, China
Authors: Liu Li , Gu Haiting , Xu Yue-Ping , Zheng Chaohao , Zhou Peng 
Published: January 2023

Abstract
Supertyphoon rainstorms are apposite examples to evaluate the utility of multisource precipitation products in monitoring and forecasting short-duration heavy rainfall and the resulting intense floods. In this study, the record-breaking floods induced by Typhoon Lekima in Jiao River, China, were retrospectively forecasted. The Xinanjiang (XAJ) model was calibrated based on parameter regionalization derived from SOM+k-means clustering. Via XAJ, the performance of the currently prevailing atmosphere reanalysis (CLDASv2 and CMA-CMORP), quantitative precipitation estimation (QPE) (IMERG-ER and PERSIANN-CCS), and quantitative precipitation forecasts (QPFs) (GRAPES_MESO, ECMWF, and GFS) in monitoring and forecasting Lekima rainfall and flood was comprehensively evaluated. A three-component blended ensemble was proposed, by blending QPE nowcasts with the weighted ensemble of QPFs through a transition of the regional GRAPES_MESO, and compared with two conventional two-component blending methods. The results indicated that the parameter regionalization enabled an explicit consideration of the spatial heterogeneity of basin attributes as well as meteorology, resulting in a minimum NSE of 0.81. CLDASv2 and CMA-CMORPH provided superior spatiotemporal accuracy with a structural similarity index up to 0.75 and NSE > 0.9 for the flood simulation. PERSIANN-CCS rainfall and the driven flood were seriously underestimated by 70% and 80%, respectively. The real-time application of QPFs during the Lekima flood provided encouraging results with a lead time of 40 h. The three-component blended ensemble method resulted in more stable and accurate flood forecasts, especially for the flood peak on 9 August, which was improved by 80%. Our results are expected to present support for real-time flood preparation and mitigation with practical significance.
Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats
Authors: Tijani Abiola S , Farombi Ebenezer O , Olori David O 
Published: January 2023

This present study was designed to investigate ameliorating potential of thymol (THY) on hexachlorobenzene (HBC)-induced epididymal and testicular toxicities in adult male rats. Forty adult male rats were orally treated by gavage daily for 28 consecutive days and divided into four groups; control group administered with corn oil, HBC-treated group (16 mg/kg b. wt), thymol-treated group (30 mg/kg b. wt), and HBC + THY-treated group. The results revealed that HBC exposure caused a significant decrease in the body weight change, organ weights, sperm functional parameters, serum testosterone level with widespread histological abnormalities. Furthermore, HBC-treated rats showed increased in the serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), epididymal and testicular myeloperoxidase activity, tumor necrosis-α, interleukin-1β level and caspase-3 activity, induced oxidative damage as evidenced by elevated malondialdehyde (MDA), reactive oxygen species (RONS) levels and significant reduction in antioxidant enzyme activities and reduced glutathione (GSH). However, co-treatment of THY with HBC alleviated the HBC-induced epididymal and testicular toxicities. Our findings revealed that HBC acts as a reproductive toxicant in rats and thymol could be a potential remedial agent for HBC-induced reproductive toxicity.
Relationship and Gender Equity Measurement Among Gender-Inclusive Young Women and Non-Binary Youth in British Columbia (RE-IMAGYN BC): Planning a Youth-Led, Community-Based, Qualitative Research Study
Authors: Closson Kalysha , Nemutambwe Tadiwa , Osborne Zoë , Lee Gem Y. , Hangle Colby , Stephenson Sadie , Magagula Patience , Leonce Ivan , Raj Anita , Nicholson Valerie , Kaida Angela 
Published: January 2023

Gender-based power dynamics within intimate relationships such as controlling behaviours are driven by inequitable gender norms that perpetuate intimate partner violence (IPV). Yet, the ways in which we understand and measure gender-based power dynamics focus on the relationships of monogamous, cisgender, white, heterosexual women. This paper outlines our process of planning and implementing a qualitative, youth-led, community-based research (CBR) study exploring how diverse youth with intersecting identities perceive existing measures of gender equity and understand gender equity based on their own relationships. Between August-November 2022, we used purposive sampling to recruit 30 gender-inclusive young women and non-binary youth aged 17–29 with diverse identities, who live in British Columbia (BC), and have recent experience in a non-heterosexual and/or non-monogamous relationship (within prior 12 months). Using CBR methods, we hired and trained three Youth Research Associates (YRAs) and convened a 10-member Youth Advisory Committee (YAC) comprised of youth aged 19–28 years with queer, trans, and/or non-monogamous identities and experiences to consult on all aspects of our study. YRAs conducted cognitive interviews using an interview guide co-developed and piloted in partnership with the YAC and YRAs. Cognitive interviews explored youth perceptions of gender equity and two gender equity measures widely used in health research today. Interview data will be analyzed collaboratively using intersectional descriptive and thematic analysis. Results from our CBR study will be used to make recommendations to advance gender equity measurement to be more inclusive of and applicable to a diversity of youth relationships, experiences, and identities.
Resveratrol ameliorates bisphenol A-induced testicular toxicity in adult male rats: a stereological and functional study
Authors: Bordbar Hossein , Yahyavi Seyedeh-Saeedeh , Noorafshan Ali , Aliabadi Elham , Naseh Maryam 
Published: January 2023

Abstract
Background
Bisphenol A (BPA) is one of the most widely used synthetic chemicals worldwide. BPA as an endocrine disruptor affects the reproductive systems through estrogenic and antiandrogenic proprieties. Resveratrol (RES) as a natural polyphenol and potent antioxidant exhibits protective effects against reproductive toxicity by inhibiting of oxidative stress. 48 male rats were divided into eight groups (n=6), including CONTROL, OLIVE OIL (0.5 ml/ day), Carboxy methylcellulose (CMC) (1 ml of 10 g/l), RES (100mg/kg/day), low dose of BPA (25 mg/kg/day), high dose of BPA (50 mg/kg/day), low dose of BPA + RES, and high dose of BPA + RES. All treatments were done orally per day for 56 days. At the end of the 8th week, blood samples were collected for hormone assays. Then, the sperm parameters were analyzed, and the left testis was removed for stereological study.

Results
We showed a significant decrease in sperm parameters in the low and high doses of BPA groups compared to control groups (P<0.05). The volume of testicular components as well as the diameter and length of seminiferous tubules significantly reduced (11-64 %), and the total number of the testicular cell types decreased (34-67 %) on average in the low and high doses of BPA groups. Moreover, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone hormones concentration showed a significant reduction in both doses of BPA groups (P<0.01). Nonetheless, treatment with RES could ameliorate all the above-mentioned changes in the low and high doses of BPA groups (P<0.05).

Conclusions
RES could prevent BPA-induced testicular structural changes and sperm quality via improving gonadotropin hormones and testosterone levels.
Spinal infection caused by Coxiella burnetii
Authors: Yang Sumin , Xue Bai , Hu Xiaowen , Zhou Weidong , Zhang Minglei , Zhao Mingwei 
Published: January 2023

Abstract
Background
Spinal infection caused by Coxiella burnetii is rare and difficult to diagnose. Here we reported a case of spinal infection from Coxiella burnetii detected by the metagenomic next-generation sequencing (mNGS).

Case presentation
A 66-year-old male farmer with no medical history reported severe sharp low back pain, numbness and lower limb weakness for three years. Magnetic resonance imaging (MRI) revealed bone destruction and spinal cord compression within L1 and L2. mNGS testing showed that the inspected specimen collected from spinal lesion was detected positively for Coxiella burnetii. After receiving the combined treatment of antibiotic therapy and surgical intervention, the patient recovered well, and the sagittal MRI showed that vertebral edema signals disappeared and the graft of bone fused 16 months after surgery.

Conclusion
The mNGS may be benefit for early diagnosis and intervention of non-specific spinal infection, and future studies should validate its effectiveness for clinical use in spinal infections. Additionally, antibiotic therapy combined with surgical intervention plays an important role on the treatment of spinal infection caused by Coxiella burnetii.
Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma
Authors: Wang Min , Qiu Zu-Hua , Wang Yu-Zhuo , Lian Bo , Bai Jing-Kun , Zhou Yong-Jie , Ji Hong-Jie 
Published: January 2023

Abstract
Background
Hepatocellular carcinoma (HCC) remains one of the most common and lethal malignancies worldwide. Although DBF4-dependent kinase (DDK) complex composed of CDC7 kinase and its regulatory subunit DBF4 has been shown to be overexpressed in primary tumors and promotes tumor development, while its role and prognostic value in HCC remain largely unknown. In the present study, the expression of DBF4 and CDC7 and their relationship with clinical characteristics were comprehensively analyzed.

Methods
The mRNA expression profiles of HCC and the corresponding clinical data of HCC patients were downloaded from TCGA and GEO databases, respectively. The differences in DBF4 and CDC7 expression in tumor tissues and adjacent normal tissues were analyzed. HCC-derived tissue microarray (TMA) was used to evaluate and score the expression of CDC7 by immunohistochemistry (IHC) staining. The Kaplan–Meier method and the Cox regression method were used to analyze the relationship between overall survival and clinical characteristics of the patients. Gene set enrichment analysis (GSEA) was used to analyze the pathway enrichment of DBF4 and CDC7.

Results
DBF4 and CDC7 had similar expression patterns in HCC patients. Detailly, compared with adjacent tissues, both mRNA and protein of DBF4 and CDC7 were significantly higher in HCC, and their expression was positively correlated with AJCC_T stage, clinical stage and G stage (grade) of liver cancer patients, and higher DBF4 or CDC7 expression predicted a worse prognosis in HCC patients with shorter overall survival (OS), recurrence-free survival (RFS), disease-specific survival (DSS) and progress-free survival (PFS). Cox regression analysis suggested that both DBF4 and CDC7 were independent risk factors for the prognosis of HCC patients in TCGA dataset. GSEA suggested that both DBF4 and CDC7 were positively correlated with cell cycle and DNA replication. Finally, the prognostic value of CDC7 was furtherly confirmed by TMA-based IHC staining results.

Conclusions
Our study showed that DDK complex was significantly increased in HCC. Both DBF4 and CDC7 may be potential diagnostic and prognostic markers for HCC, and high expression of DDK members predicts a worse prognosis in patients with HCC, which may be associated with high tumor cell proliferation rate.
Investigating the functional role of SETD6 in lung adenocarcinoma
Authors: Xu Jing , Zhou Hui , Luo Ziling , Chen Jie , Liu Man 
Published: January 2023

Abstract
Background
SET domain containing 6 (SETD6) has been shown to be upregulated in multiple human cancers and can promote malignant cell survival. However, expression and function of SETD6 in lung adenocarcinoma (LUAD) remains unaddressed. This study aimed to demonstrate the expression pattern, biological roles and potential mechanisms by which SETD6 dysregulation is associated with LUAD.

Methods
The expression level of SETD6 was evaluated in LUAD clinical specimens and its correlation with clinical parameters were analyzed. In vitro, gain-of-function and loss-of-function experiments were performed to evaluate the effects of SETD6 on cell proliferation, apoptosis, migration, and colony formation of LUAD cell line A549. Western-blot was performed to investigate the involvement of nuclear factor-κB (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) pathways as downstream signaling of SETD6 in LUAD cells.

Results
Compared with non-tumorous tissues, SETD6 was overexpressed in tumor tissues, and its overexpression significantly correlates with higher rates of regional lymph node metastasis and poor prognosis in patients with LUAD. In A549 cell line, SETD6 overexpression could promote cell proliferation, migration, colony formation and inhibit cell apoptosis, whereas SETD6 knockdown caused the opposite effects. Furthermore, we demonstrated that the mechanisms underlying the effect of SETD6 on LUAD biological behaviors may be through its interaction with NF-κB and Nrf2 signaling pathways.

Conclusions
SETD6, which is highly expressed in LUAD tumor tissues, plays an important role in promoting the malignant behaviors of LUAD via likely the NF-κB and Nrf2 signaling pathways.
Implementation of a home-based colorectal cancer screening intervention in Malaysia (CRC-SIM)
Authors: Schliemann Désirée , Ramanathan Kogila , Ibrahim Tamin Nor Saleha Binti , O’Neill Ciaran , Cardwell Christopher R , Ismail Roshidi , Kassim Zaid , Kee Frank , Su Tin Tin , Donnelly Michael 
Published: January 2023

Abstract
Introduction
The Colorectal Cancer Screening Intervention for Malaysia (CRC-SIM) was a CRC study of home-based testing designed to improve low screening uptake using the immunochemical fecal occult blood test (iFOBT) in Malaysia.

Methods
This quasi-experimental study was informed by the Implementation Research Logic Model and evaluated with the RE-AIM framework. Trained data collectors recruited by phone, randomly selected, asymptomatic adults aged 50-75 years from Segamat District, who previously completed a health census form for the South East Asia Community Observatory (SEACO). Participants were posted an iFOBT kit and asked to return a photo of the completed test for screening by health care professionals. A regression analysis of evaluation data was conducted to identify which variables were associated with the outcome indicators of ‘study participation’ and ‘iFOBT completion’ and the CRC-SIM was evaluated in terms of its appropriateness, feasibility and acceptability.

Results
Seven hundred forty-seven eligible adults (52%) agreed to participate in this study and received an iFOBT kit. Participation was significantly lower amongst Chinese Malaysians (adjusted OR 0.45, 95% CI 0.35 - 0.59, p<0.001) compared to Malays and amongst participants from the rural sub-district (Gemereh) (adjusted OR 0.71, 95% CI 0.54 - 0.92, p=0.011) compared to the urban sub-district (Sungai Segamat). Less than half of participants (42%, n=311/747) completed the iFOBT. Test-kit completion was significantly higher amongst Chinese Malaysians (adjusted OR 3.15, 95% CI 2.11 - 4.69, p<0.001) and lower amongst participants with a monthly household income ≥RM 4,850 (adjusted OR 0.58, 95% CI 0.39 - 0.87, p=0.009) compared to participants with a lower household income. The main reported reason for non-participation was ‘not interested’ (58.6%) and main implementation challenges related to invalid photographs from participants and engaging iFOBT positive participants in further clinic consultations and procedures.

Conclusion
Home-testing for CRC (test completion) appeared to be acceptable to only around one-fifth of the target population in Malaysia. However, mindful of the challenging circumstances surrounding the pandemic, the CRC-SIM merits consideration by public health planners as a method of increasing screening in Malaysia, and other low- and middle-income countries.