bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cautionary note on the use of N-acetylcysteine as a reactive oxygen species antagonist to assess copper mediated cell death
Authors: Graham Rebecca E. , Elliott Richard J. R. , Munro Alison F. , Carragher Neil O. 
Published: July 2023

AbstractA new form of cell death has recently been proposed involving copper-induced cell death, termed cuproptosis. This new form of cell death has been widely studied in relation to a novel class of copper ionophores, including elesclomol and disulfiram. However, the exact mechanism leading to cell death remains contentious. The oldest and mostly widely accepted biological mechanism is that the accumulated intracellular copper leads to excessive build-up of reactive oxygen species and that this is what ultimately leads to cell death. Most of this evidence is largely based on studies using N-acetylcysteine (NAC), an antioxidant, to relieve the oxidative stress and prevent cell death. However, here we have demonstrated using inductively coupled mass-spectrometry, that NAC pretreatment significantly reduces intracellular copper uptake triggered by the ionophores, elesclomol and disulfiram, suggesting that reduction in copper uptake, rather than the antioxidant activity of NAC, is responsible for the diminished cell death. We present further data showing that key mediators of reactive oxygen species are not upregulated in response to elesclomol treatment, and further that sensitivity of cancer cell lines to reactive oxygen species does not correlate with sensitivity to these copper ionophores. Our findings are in line with several recent studies proposing the mechanism of cuproptosis is instead via copper mediated aggregation of proteins, resulting in proteotoxic stress leading to cell death.Overall, it is vital to disseminate this key piece of information regarding NAC’s activity on copper uptake since new research attributing the effect of NAC on copper ionophore activity to quenching of reactive oxygen species is being published regularly and our studies suggest their conclusions may be misleading.
Methanolic extracts of the edible halophyteCrithmum maritimumenhance oxidative stress resistance inCaenorhabditis elegansthrough hormetic mechanisms
Authors: Martins-Noguerol Raquel , Mata-Cabana Alejandro , Olmedo María , DeAndrés-Gil Cristina , Moreira Xoaquín , Francisco Marta , Moreno-Pérez Antonio J. , Cambrollé Jesús 
Published: July 2023

AbstractHalophytes are promising sources of bioactive phenolic compounds for the food and pharmaceutical industries. However, their phenolic composition is influenced by environmental conditions, and thein vivoantioxidant activity of their phytochemicals is largely unknown. We evaluated the antioxidant capacity of phenolic-rich methanolic extracts from the edible halophyteCrithmum maritimum, grown in wild and greenhouse conditions. Additionally, theirin vivoantioxidant capacity was analyzed for the first time using the modelCaenorhabditis elegans. Wild plant extracts showed higher phenolic content and diversity, andin vitroantioxidant activity. Both extracts enhanced oxidative stress resistance and increased nematode survival rates, albeit to varying extents, and increased reactive oxygen species production in nematodes, without affecting their lifespan, suggesting a hormetic mechanism. Although no neuroprotective effects were observed in models of neurodegenerative diseases, these findings highlight the potential ofC. maritimumas a valuable source of phenolics with antioxidant properties for the food industry.
Shedding light on the Ophel biome: The Trans-Tethyan phylogeography of the sulfide shrimpTethysbaena(Peracarida: Thermosbaenacea) in the Levant
Authors: Guy-Haim Tamar , Kolodny Oren , Frumkin Amos , Achituv Yair , Velasquez Ximena , Morov Arseniy R. 
Published: July 2023

ABSTRACTTethysbaenaare small peracarid crustaceans found in extreme environments such as subterranean lakes and thermal springs, represented by endemic species found around the ancient Tethys, including the Mediterranean, Arabian Sea, Mid-East Atlantic, and the Caribbean Sea. TwoTethysbaenaspecies are known from the Levant:T. relicta, inhabiting the Dead Sea-Jordan Rift Valley, andT. ophelicola, found in the Ayyalon cave complex in the Israeli coastal plain, both belonging to the same species-group based on morphological cladistics. Along the biospeleological research of the Levantine subterranean fauna, three biogeographic hypotheses determining their origins were proposed: (1) Pliocenic transgression, (2) Mid-late Miocenic transgression, and (3) The Ophel Paradigm, according to which these are inhabitants of a chemosynthetic biome as old as the Cambrian. We have used mtDNA COI gene and a molecular clock approach to establish the phylogeny and assess the divergence times of the LevantineTethysbaena. Contrary to prior hypotheses, our results indicate a two-stage colonization pattern: a late Oligocene transgression, through a marine gulf extending from the Arabian Sea, leading to the colonization ofT. relictain the Dead Sea-Jordan Rift Valley, and a Miocene transgression in the emerging Mediterranean region, carryingT. ophelicolato the coastal plain of Israel.
Sleep maintains excitatory synapse diversity in the cortex and hippocampus
Authors: Koukaroudi Dimitra , Qiu Zhen , Fransén Erik , Gokhale Ragini , Bulovaite Edita , Komiyama Noboru H. , Seibt Julie , Grant Seth G.N. 
Published: July 2023

AbstractHow sleep deprivation affects cognition remains elusive. Synaptome mapping of excitatory synapses in 125 regions of the mouse brain revealed that sleep deprivation selectively reduces synapse diversity in the cortex and hippocampus. Sleep deprivation targeted specific types and subtypes of excitatory synapses while maintaining total synapse density. Altered synaptic responses to neural oscillations in a computational model suggest that sleep prevents cognitive impairments by maintaining normal brain synaptome architecture.
Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets
Authors: Stratiievska Anastasiia , Filippova Olga , Özpolat Tahsin , Byrne Daire , Lawrence Bailey S. , Mollica Molly Y. , Harris Jeff , Esancy Kali , Chen Junmei , Dhaka Ajay K. , Sniadecki Nathan J. , López José A , Stolla Moritz 
Published: July 2023

AbstractPlatelets are sensitive to temperature changes and akin to sensory neurons, are activated by a decrease in temperature. However, the molecular mechanism of this temperature-sensing ability is unknown. Yet, platelet activation by temperature could contribute to numerous clinical sequelae, most importantly to reduced quality ofex vivo-stored platelets for transfusion. In this interdisciplinary study, we present evidence for the expression of the temperature-sensitive ion channel transient receptor potential cation channel subfamily member 8 (TRPM8) in human platelets and precursor cells. We found the TRPM8 mRNA and protein in MEG-01 cells and platelets. Inhibition of TRPM8 prevented temperature-induced platelet activation and shape change. However, chemical agonists of TRPM8 did not seem to have an acute effect on platelets. When exposing platelets to below-normal body temperature, we detected a cytosolic calcium increase which was independent of TRPM8 but was completely dependent on the calcium release from the endoplasmic reticulum. Because of the high interindividual variability of TRPM8 expression, a population-based approach should be the focus of future studies. Our study suggests that the cold response of platelets is complex and TRPM8 appears to play a role in early temperature-induced activation of platelets, while other mechanisms likely contribute to later stages of temperature-mediated platelet response.
Insight into the risk-resistant function of ESG performance: An organizational management perspective
Authors: Zhang Yue , Zhang Changjiang , Zhang Sihan , Yang Yuqi , Lan Kai 
Published: July 2023

Purpose
This study aims to examine the risk-resistant role of environmental, social and governance (ESG) performance in the capital market, focusing on an organizational standpoint. Furthermore, it aims to offer management decision advice to companies seeking protection against stock market risks. Conclusions obtained through this research have the potential to enrich the economic consequences of ESG performance, provide practical implications for enhancing corporate ESG performance, improving corporate information quality and stabilizing capital market development.

Design/methodology/approach
Based on the data of Chinese A-share listed companies from 2009 to 2020, this study examines the risk-resistant function of ESG performance in the capital market. The impact of ESG performance on management behavior is analyzed from the perspective of organizational management and the three mechanisms of pre-event, during the event and post-event.

Findings
This paper demonstrates that companies that effectively implement ESG practices are capable of effectively mitigating risks associated with stock price crashes. Heterogeneity analysis reveals that the inhibitory effect of ESG performance on stock price crash risk is more pronounced in nonstate-owned enterprises and enterprises with higher levels of marketization. After controlling for issues such as endogeneity, the conclusions of this paper are still valid. The mechanism analysis indicates that ESG performance reduces the risk of stock price crash through three paths of organizational management: pre-event, during the event and post-event. That is, ESG performance plays the role of restraining managers’ opportunistic behavior, reducing information asymmetry and boosting investor sentiment.

Originality/value
This paper provides new insights into the relationship between ESG performance and stock price crash risk from an organizational management perspective. This study establishes three impact mechanisms (governance effect, information effect and insurance effect), offering a theoretical basis for strategic corporate decisions of risk management. Additionally, it comprehensively examines the contextual differences in the role of ESG performance, shedding light on the specific domains where ESG practices are influential. These findings offer valuable insights for promoting stable development in the capital market and fostering the healthy growth of the real economy.
Family influences on entrepreneurial orientation in immigrant entrepreneurship
Authors: Ljungkvist Torbjörn , Evansluong Quang , Boers Börje 
Published: July 2023

PurposeThis study explores how the family influences the entrepreneurial orientation (EO) process in immigrant businesses.Design/methodology/approachThe paper draws on inductive multiple-case studies using 34 in-depth interviews. This paper relies on three cases of immigrant entrepreneurs originating from Mexico and Colombia that established firms in Sweden.FindingsThe results suggest that EO development trajectories vary in the presence of family roles (i.e. inspirers, backers and partners), resulting in the immigrant family business configurations of family-role-influenced proactiveness, risk-taking and innovation.Originality/valueThe immigrant family configurations drive three EO-enabling scenarios: (1) home-country framing, (2) family backing and (3) transnational translating. Immigrant family dynamics facilitate the development of EO over time through reciprocal interaction processes across contexts. This study indicates that, through family dynamics, EO develops as mutually interactive processes between the immigrant entrepreneur's family in the home and host countries.
Market segmentation based on customer experience dimensions extracted from online reviews using data mining
Authors: Pandey Shweta , Pandey Neeraj , Chawla Deepak 
Published: July 2023

Purpose
This study aims to develop a practical and effective approach for market segmentation using customer experience dimensions derived from online reviews.

Design/methodology/approach
The research investigates over 6,500 customer evaluations of food establishments on Taiwan’s Yelp platform through the Latent Dirichlet allocation (LDA) data mining approach. By using the LDA-derived experience dimensions, cluster analysis discloses market segments. Subsequently, sentiment analysis is used to scrutinize the emotional scores of each segment.

Findings
Mining online review data helps discern divergent and new customer experience dimensions and sheds light on the divergent preferences among identified customer segments concerning these dimensions. Moreover, the polarity of sentiments expressed by consumers varies across such segments.

Research limitations/implications
Analyzing customer attributes extracted from online reviews for segmentation can enhance comprehension of customers’ needs. Further, using sentiment analysis and attributes of online reviews result in rich profiling of the identified segments, revealing gaps and opportunities for marketers.

Originality/value
This research presents a new approach to segmentation, which surmounts the restrictions of segmentation methods dependent on survey-based information. It contributes to the field and provides a valuable means for conducting customer-focused market segmentation. Furthermore, the suggested methodology is transferable across different sectors and not reliant on particular data sources, creating possibilities in diverse scenarios.
COVID-19 and global supply chain risks mitigation: systematic review using a scientometric technique
Authors: Fernando Yudi , Al-Madani Mohammed Hammam Mohammed , Shaharudin Muhammad Shabir 
Published: July 2023

Purpose
This paper aims to investigate how manufacturing firms behave to mitigate business risk during and post-COVID-19 coronavirus disease (COVID-19) on the global supply chain.

Design/methodology/approach
A systematic literature review for data mining was used to address the research objective. Multiple scientometric techniques (e.g. bibliometric, machine learning and social network analysis) were used to analyse the Lens.org, Web of Science and Scopus databases’ global supply chain risk mitigation data.

Findings
The findings show that the firms’ manufacturing supply chains used digitalisation technologies such as Blockchain, artificial intelligence (AI), 3D printing and machine learning to mitigate COVID-19. On the other hand, food security, government incentives and policies, health-care systems, energy and the circular economy require more research in the global supply chain.

Practical implications
Global supply chain managers were advised to use digitalisation technology to mitigate current and upcoming disruptions. The manufacturing supply chain has high uncertainty and unpredictable global pandemics. Manufacturing firms should consider adopting Blockchain technology, AI and machine learning to mitigate the epidemic risk and disruption.

Originality/value
This study found the publication trend of how manufacturing firms behave to mitigate the global supply chain disruptions during the global pandemic and business uncertainty. The findings have contributed to the supply chain risk mitigation literature and the solution framework.
Social enterprise housing supply chains for resource-constrained communities: a complexity lens approach
Authors: Boehme Tillmann , Fan Joshua , Birtchnell Thomas , Aitken James , Turner Neil , Deakins Eric 
Published: July 2023

Purpose
Delivering housing to resource-constrained communities (RCCs) is a complex process beset with difficulties. The purpose of this study is to use a complexity lens to examine the approach taken by a social enterprise (SE) in Australia to develop and manage a housebuilding supply chain for RCCs.

Design/methodology/approach
The research team used a longitudinal case study approach from 2017 to 2022, which used mixed methods to understand the phenomenon and gain an in-depth understanding of the complex issues and problem-solving undertaken by an SE start-up.

Findings
Balancing mission logic with commercial viability is challenging for an SE. The supply chain solution that evolved accommodated the particulars of geography and the needs of many stakeholders, including the end-user community and government sponsors. Extensive and time-consuming socialisation and customisation led to a successful technical design and sustainable supply chain operation.

Practical implications
Analysing supply chain intricacies via a complexity framework is valuable for scholars and practitioners, assisting in designing and developing supply chain configurations and understanding their dynamics. Meeting the housing construction needs of RCCs requires the SE to place societal focus at the centre of the supply chain rather than merely being a system output. The developed business model complements the engineering solution to empower a community-led housing construction supply chain.

Originality/value
This longitudinal case study contributes to knowledge by providing rich insights into the roles of SEs and how they develop and operate supply chains to fit with the needs of RCCs. Adding a contextual response dimension to an established complexity framework helped to explain how hybrid organisations balance commercial viability demands with social mission logic by amending traditional supply chain and governance practices. The case provides insights into supply chain configuration, needed changes and potential impacts when an SE as a focal actor inserts into a traditional for-profit construction supply chain.
Concomitant gallstone disease was not associated with long‐term outcomes in ursodeoxycholic acid‐treated patients with primary biliary cholangitis
Authors: Chen Sha , Li Meng Qi , Li Bu Er , Lv Ting Ting , Li Shu Xiang , Shan Shan , Li Min , Kong Yuan Yuan , Zhang Dong , Ma Hong , Ou Xiao Juan , You Hong , Duan Wei Jia , Jia Ji Dong 
Published: July 2023

ObjectivesPrimary biliary cholangitis (PBC) is a rare disease characterized by intrahepatic cholestasis, whereas gallstone disease (GD) is common. In this study, we aimed to investigate the prevalence and impact of GD on the prognosis of PBC in China.MethodsMedical records of the PBC patients were retrospectively reviewed and their follow‐up data were obtained via regular structured, standardized telephone interviews. GD was defined as gallstones on ultrasonography or a history of cholecystectomy for gallstones. Propensity score matching (PSM) and Cox regression analysis were performed. The primary end‐point was liver‐related death and/or liver transplantation.ResultsA total of 985 ursodeoxycholic acid (UDCA)‐treated PBC patients were enrolled with a median follow‐up duration of 5.3 years (range 1.0–20.9 years). Among them, 258 (26.2%) had GD, including 157 (22.9%) of non‐cirrhotic and 101 (33.8%) of cirrhotic patients. Compared with PBC without GD, those with GD were older, more often had type 2 diabetes mellitus, and had a more severe liver disease at baseline. After PSM (1:2), 229 PBC patients with GD were matched with 458 PBC patients without GD based on age, sex, cirrhosis, and total bilirubin level. The transplant‐free survival and incidence of hepatic events were similar between the two groups. Furthermore, multivariate Cox regression analysis showed that concomitant GD was not independently associated with a worse prognosis for PBC patients.ConclusionConcomitant GD was common but was not associated with long‐term outcomes in patients with UDCA‐treated PBC.
Organic Matter Accumulation in the Upper Permian Dalong Formation from the Lower Yangtze Region, South China
Authors: FANG Chaogang , ZHANG Chengcheng , MENG Guixi , XU Jinlong , XU Naicen , LI Hualing , LIU Mu , LIU Bo 
Published: July 2023

AbstractThe Late Permian was marked by a series of important geological events and widespread organic‐rich black shale depositions, acting as important unconventional hydrocarbon source rocks. However, the mechanism of organic matter (OM) enrichment throughout this period is still controversial. Based on geochemical data, the marine redox conditions, paleogeographic and hydrographic environment, primary productivity, volcanism, and terrigenous input during the Late Permian in the Lower Yangtze region have been studied from the Putaoling section, Chaohu, to provide new insights into OM accumulation. Five Phases are distinguished based on the TOC and environmental variations. In Phase I, anoxic conditions driven by water restriction enhanced OM preservation. In Phase II, euxinic and cycling hydrological environments were the two most substantial controlling factors for the massive OM deposition. During Phase III, intensified terrestrial input potentially diluted the OM in sediment and the presence of oxygen in bottom water weakened the preservation condition. Phase IV was characterized by a relatively higher abundance of mercury (Hg) and TOC (peak at 16.98 wt%), indicating that enhanced volcanism potentially stimulated higher productivity and a euxinic environment. In Phase V, extremely lean OM was preserved as a result of terrestrial dilutions and decreasing primary productivity. Phases I, II and IV are characterized as the most prominent OM‐rich zones due to the effective interactions of the controlling factors, namely paleogeographic, hydrographic environment, volcanism, and redox conditions.
Farm‐level responses to weather trends: A structural model
Authors: Wimmer Stefan , Stetter Christian , Schmitt Jonas , Finger Robert 
Published: July 2023

AbstractAssessing the effects of weather and climate on agricultural production is crucial for designing policies related to climate change adaptation and mitigation. A large body of literature has identified the detrimental effects of climate change on crop yields worldwide, and farm‐level adaptation has been shown to mitigate the adverse effects on agricultural production. In this study, we employ a structural model to examine farm production responses to ongoing weather trends. We investigate how farmers adjust output and input decisions by estimating a system of output supply and input demand functions, controlling for nonrandom crop selection. Using panel data with 14,796 observations reflecting 1638 German crop farms (1996–2019), we find that both the expected and realized weather determine farmers' production decisions. In the event of a drought, the supply of most considered crops and the demand for fertilizer decrease. The drought shock has also lasting effects on farmers' production decisions, with a reduced supply of protein crops and an increased level of root crops production in subsequent years. These findings highlight the need to account for farm‐level production responses when assessing weather and climate impacts.