bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterocyclic and non‐heterocyclic arena of monocarboxylate transporter inhibitors to battle tumorigenesis
Authors: Manisha Deepthi S. , Ratheesh Anandu Kizhakkedath , Benny Sonu , Presanna Aneesh Thankappan 
Published: September 2023

AbstractMonocarboxylate transporters (MCTs) have gained significant attention in cancer research due to their critical role in tumour metabolism. MCTs are legends for transporting lactate molecules in cancer cells, an oncometabolite and waste product of glycolysis, acting as an indispensable factor of tumour proliferation. Targeting MCTs with inhibitors has emerged as a promising strategy to combat tumorigenesis. This article summarizes the most recent research on MCT inhibitors in preventing carcinogenesis, covering both heterocyclic and non‐heterocyclic compounds. Heterocyclic and non‐heterocyclic compounds such as pteridine, pyrazole, indole, flavonoids, coumarin derivatives and cyanoacetic acid derivatives have been reported as potent MCT inhibitors. We examine the molecular underpinnings of MCTs in cancer metabolism, the design and synthesis of heterocyclic and non‐heterocyclic MCT inhibitors, their impact on tumour cells and the microenvironment and their potential as therapeutic agents. Moreover, we explore the challenges associated with MCT inhibitor development and propose future directions for advancing this field. This write‐up aims to provide researchers, scientists and clinicians with a comprehensive understanding of the heterocyclic and non‐heterocyclic MCT inhibitors and their potential in combating tumorigenesis.
The promise of leveraging social identities in interventions to enhance the well‐being and lives of adolescents
Authors: Hoffman Adam J. , Umaña‐Taylor Adriana J. 
Published: September 2023

AbstractIdentity development is theorized to be a cornerstone of adolescence. An abundance of evidence has documented the significance of specific social identities (e.g., ethnic‐racial or sexual identity) in the adjustment of adolescents. Research has found that youth who have explored their social identities and have more positive views of their social groups are likely to adjust more successfully across many developmental outcomes. Given evidence documenting the importance of social identities, in this article, we argue that identities should be leveraged to promote positive adjustment, particularly among youth experiencing marginalization. We present a theoretically driven rationale for why social identities should be considered assets that provide opportunities for intervention to improve youth's lives. We also describe two interventions that efficaciously targeted social identity development and demonstrated positive effects on adjustment. We close with directions for research and implementation and a call to invest in this important work.
Combining community science and taxonomist expertise for large‐scale monitoring of insect pollinators: Perspective and insights from Abeilles citoyennes
Authors: Rondeau Sabrina , Gervais Amélie , Leboeuf Anne , Drapeau Picard André‐Philippe , Larrivée Maxim , Fournier Valérie 
Published: September 2023

AbstractWhile evidence of insect pollinator declines accumulates, little is known about the pollinator communities that are most vulnerable to population fluctuations and may require conservation actions. Among the main reasons for this lack of knowledge about the status and trends of native pollinators are the time, cost, and expertise required to collect and identify wild insect pollinators (bees, more specifically). Here, we discuss how leveraging the complementarity of community science and taxonomist expertise can help overcome these challenges and provide perspective and insights from launching the large‐scale monitoring program Abeilles citoyennes. The overall objective of this community science project is to monitor wild bee (Apoidea) and hover fly (Syrphidae) diversity in the province of Quebec, Canada, and study the effects of landscape composition on their communities. From 2019 to 2021, 131 volunteers collected insects at 161 sites across the province. A total of 13,558 bees and 2,486 hover flies were collected and identified to species. The project protocol and potential data uses are presented, along with a discussion of the benefits and challenges of using an expert‐assisted community science approach for pollinator monitoring and opportunities for improvement.
Pharmacokinetics, safety, and tolerability of inhaled remdesivir in healthy participants
Authors: Humeniuk Rita , Juneja Kavita , Chen Shuguang , Ellis Scott , Anoshchenko Olena , Xiao Deqing , Share Aaron , Johnston Matthew , Davies Santosh , DeZure Adam , Llewellyn Joe , Osinusi Anu , Winter Helen , Girish Sandhya , Palaparthy Ramesh , Dresser Mark 
Published: September 2023

AbstractIntravenous remdesivir (RDV) is US Food and Drug Administration–approved for hospitalized and nonhospitalized individuals with coronavirus disease 2019. RDV undergoes intracellular metabolic activation to form the active triphosphate, GS‐443902, and other metabolites. Alternative administration routes, including localized pulmonary delivery, can lower systemic exposure and maximize exposure at the site of action. This study evaluated the pharmacokinetics (PK) and safety of inhaled RDV in healthy adults. This phase Ia, randomized, placebo‐controlled study evaluated inhaled RDV in healthy participants randomized 4:1 to receive RDV or placebo as single doses (4 cohorts) or multiple once‐daily doses (3 cohorts). Doses in cohorts 1–6 were administered as an aerosolized solution for inhalation through a sealed facemask; doses in cohort 7 were administered as an aerosolized solution for inhalation through a mouthpiece. Safety was assessed throughout the study. Seventy‐two participants were enrolled (inhaled RDV, n = 58 and placebo, n = 14). Following single RDV doses, RDV, GS‐704277, and GS‐441524 plasma PK parameters indicated dose‐proportional increases in area under the concentration‐time curve (AUC) extrapolated to infinite time, AUC from time zero to last quantifiable concentration, and maximum observed concentration. Analyte plasma concentrations after multiple RDV doses were consistent with those for single‐dose RDV. Analyte plasma exposures were lower when RDV was administered with a mouthpiece versus a sealed facemask. The most common adverse events included nausea, dizziness, and cough. Single‐ and multiple‐dose inhaled RDV exhibited linear and dose‐proportional plasma PK. Administration of RDV via inhalation was generally safe and well‐tolerated.
Theory of mind and executive dysfunction in chronic inflammatory demyelinating polyneuropathy
Authors: Lochmann Hannah , Wyrobnik Michelle , Kupper Christin , Rewitzer Charlotte , Klostermann Fabian 
Published: September 2023

AbstractBackground and purposeAlthough chronic inflammatory demyelinating polyneuropathy (CIDP) is understood as a disease affecting the peripheral nervous system, mild cognitive dysfunction, particularly in the executive domain, has been described to form part of the condition. Here our interest lay in CIDP‐related theory of mind (ToM) capacities as an aspect of social cognition relevant for many aspects of everyday life.MethodsTwenty‐nine patients with CIDP and 23 healthy controls participated in this study. They were subjected to overview cognitive testing, different executive function (EF) tasks, as well as to the Faux Pas Recognition Task (FPRT) for assessing cognitive ToM and the Reading the Mind in the Eyes Test (RMET) with respect to affective ToM.ResultsPersons with CIDP and controls did not differ with respect to their overall cognitive state. However, in the German verbal fluency standard, the digit span forward and the digit span backward tests used as EF tasks patients performed significantly worse than controls. Further, performance was abnormally low in the FPRT, whilst the groups did not differ with respect to RMET results. The FPRT and digit span backward results correlated with each other.ConclusionsPatients with CIDP showed deficits in cognitive ToM performance together with EF dysfunction, whilst affective ToM was preserved. Altogether, the results suggest that low cognitive ToM capacities in patients with CIDP arise as a particular aspect of disease‐related executive dysfunction.
A study on how social media influences on impulsive buying
Authors: Liu Huinan , De Costa Mohd Feroz Shah De Costa Bin Mohd Faris , Yasin Megat Al‐lmran Bin , Ruan Qijie 
Published: September 2023

AbstractThe rapid development of the Internet has led to a shift in how people communicate, with social media becoming an essential vehicle for communication and information exchange. In this context, social media influencers have emerged. With expertise in a particular field and strong influence, they can change customers' attitudes, perceptions, and behaviors. Although social media influencers have been widely studied in the marketing field, most scholars at this stage mainly study the change in customers' attitudes and purchasing behaviors towards brands, without considering the contingency of consumers' participation in influencer marketing activities in the context of social media. Plus, researchers did not pay sufficient attention to customers' impulsive purchasing behaviors. Thus, this article investigated the factors influencing customers' impulsive buying behavior in social media influencer marketing situations. This study built an elaboration likelihood model (i.e., ELM) to explore the factors and mediating variables contributing to customers' impulsive buying behavior. Questionnaires were used to explore the factors influencing customers' impulsive buying behavior in a social media influencer marketing context. Respondents' attitudes on each dimension were measured using well‐established scales from existing research, and the data were processed to draw conclusions. Findings showed that in the influencer marketing context, consumers' perceived social value and influencer expertise would not directly impact their impulsive buying behavior. Functional and emotional values could lead to impulse buying behavior, while social values would not lead to customer inspiration. Moreover, authenticity and influence both contributed to impulsive buying behaviors. The findings might have important implications for influencer marketing and further studies on impulsive buying. Companies should select authentic and influential influencers; what's more, the influencers should be sincere and enhance their influence to gain consumers' trust.
When I grow up… I don't want to be broke: The problems with child actor trust fund requirements
Authors: Gaydos Leah 
Published: September 2023

AbstractChild actors have consistently been treated as typical minority laborers, with all of their earnings legally belonging to their parents. After many child actors were left with scraps at the end of their minority, Coogan's law was enacted in California to require parents of child actors to withhold some of their earnings in a trust. However, almost a century after Coogan's law was passed, there are still many child actors left with nothing. This Note proposes to both enact further union regulations to protect child actors in every state, and also to raise the required amount withheld from fifteen percent (15%) to fifty percent (50%).
The influence of infilling material strength on mechanical properties and failure mechanism of fractured sandstone
Authors: Zhang Dong‐xiao , Wang Qing , Guo Wei‐yao , Chen Le‐xin , Jiang Yu‐jing , Zhao Yong‐qiang 
Published: September 2023

AbstractTo reveal the failure mechanism of fractured sandstone under the influence of the infilling material strength, uniaxial compression tests, and PFC3D numerical simulation analyses were conducted on fractured sandstone with different infilling material strengths, and the influence of the infilling material strength on the basic mechanical properties of the fracture‐filled sandstone was studied. The results showed that, with increasing infilling material strength, the peak strength and elastic modulus of the specimens increased nonlinearly and eventually stabilized. The failure pattern of the specimens changed from shear to tensile. When the infilling material strength was low, a wing crack or anti‐wing crack was generated; however, when the infilling material strength was high, a vertical tensile crack was generated. From the perspective of fracture mechanics, the filling of sandstone cracks can reduce or even suppress the stress concentration effect at the prefabricated crack tip and improve the bearing capacity of the fractured sandstone.
Synthesis of acetyl ferulic 7‐hydroxyisoflavone ester and evaluating its antioxidant activity on improving fish oil thermal stability
Authors: Wang Yang , Xue Zhiyong , Yao Yuanyuan , Yang Yalin , Ran Chao , Zhang Zhen , Zhou Zhigang 
Published: September 2023

SummaryAcetyl ferulic 7‐hydroxyisoflavone ester (AHE) was synthesized and its antioxidant capacity in vitro was evaluated by free radical scavenging assay and thermo‐oxidative stability analysis of fish oil in this study. The formation of primary and secondary oxidation products can be effectively inhibited by AHE, tert‐butylhydroxyquinone (TBHQ), ferulic acid and 7‐hydroxyisoflavone. The intensity of UV‐Vis absorption spectra increased significantly, whereas the intensity of fluorescence spectra decreased obviously with the deepening of oxidation degree of fish oil. AHE significantly alleviated the degradation of unsaturated fatty acids in fish oil. The results demonstrated that AHE was more effective than TBHQ, ferulic acid and 7‐hydroxyisoflavone in retarding the oxidative degradation of fish oil during high temperature storage (80 °C). Moreover, the formation of oxidation products in fish oil followed a first‐order kinetic model, and AHE effectively reduced reaction rate constant and delayed secondary lipid oxidation process. As a result, AHE is an effective antioxidant that can stabilise fish oil.
Epigenome‐wide methylation haplotype association analysis identified HLA‐DRB1, HLA‐DRB5 and HLA‐DQB1 as risk factors for rheumatoid arthritis
Authors: Xu Jing , Chen Haiyan , Sun Chen , Wei Siyu , Tao Junxian , Jia Zhe , Chen Xingyu , Lv Wenhua , Lv Hongchao , Tang Guoping , Jiang Yongshuai , Zhang Mingming 
Published: September 2023

AbstractThe aim of this study was to compare nonrandom associations between physically adjacent single methylation polymorphism loci among rheumatoid arthritis (RA) and normal subjects for investigating RA‐risk methylation haplotypes (meplotype). With 354 ACPA‐positive RA patients and 335 normal controls selected from a case–control study based on Swedish population, we conducted the first RA epigenome‐wide meplotype association study using our software EWAS2.0, mainly including (i) converted the β value to methylation genotype (menotype) data, (ii) identified methylation disequilibrium (MD) block, (iii) calculated frequent of each meplotypes in MD block and performed case–control association test and (iv) screened for RA‐risk meplotypes by odd ratio (OR) and p‐values. Ultimately, 545 meplotypes on 334 MD blocks were identified significantly associated with RA (p‐value < .05). These meplotypes were mapped to 329 candidate genes related to RA. Subsequently, combined with gene optimization, eight RA‐risk meplotypes were identified on three risk genes: HLA‐DRB1, HLA‐DRB5 and HLA‐DQB1. Our results reported the relationship between DNA methylation pattern on HLA‐DQB1 and the risk of RA for the first time, demonstrating the co‐demethylation of ‘cg22984282’ and ‘cg13423887’ on HLA‐DQB1 gene (meplotype UU, p‐value = 2.90E − 6, OR = 1.68, 95% CI = [1.35, 2.10]) may increase the risk of RA. Our results demonstrates the potential of methylation haplotype analysis to identify RA‐related genes from a new perspective and its applicability to the study of other disease.
Stress/cell death pathways, neuroinflammation, and neuropathic pain
Authors: Li Lu , Li Tian , Qu Xinyu , Sun Guangwei , Fu Qi , Han Guang 
Published: September 2023

SummaryNeuropathic pain is a common and debilitating modality of chronic pain induced by a lesion or disease of the somatosensory nervous system. Albeit the elucidation of numerous pathophysiological mechanisms and the development of potential treatment compounds, safe and reliable therapies of neuropathic pain remain poor. Multiple stress/cell death pathways have been shown to be implicated in neuroinflammation during neuropathic pain. Here, we summarize the current knowledge of stress/cell death pathways and present an overview of the roles and molecular mechanisms of stress/cell death pathways in neuroinflammation during neuropathic pain, covering intrinsic and extrinsic apoptosis, autophagy, mitophagy, ferroptosis, pyroptosis, necroptosis, and phagoptosis. Small molecule compounds that modulate stress/cell death pathways in alleviating neuropathic pain are discussed mainly based on preclinical neuropathic pain models. These findings will contribute to in‐depth understanding of the pathological processes during neuropathic pain as well as bridge the gap between basic and translational research to uncover new neuroprotective interventions.
Multifunctional tantalum disilicide ceramics sintered at high temperature and high pressure
Authors: Yu Yajie , He Shi , Zhang Zhengang , Chen Haihua , Jin Peipeng , Zhong Binnian , Zhang Linhui , Wang Liping , Lu Cheng 
Published: September 2023

AbstractSilicide ceramics are attracted significant attention due to their exceptional physical properties. However, their inherent brittleness at room temperature limits their practical applications. Here, we aim to improve the mechanical properties of tantalum disilicide (TaSi2) ceramics by modifying the preparation methods and sintering conditions. We fabricate the dense TaSi2 ceramics using high‐pressure and high‐temperature (HPHT) sintering technology at 5.5 GPa and 800–1300°C. We characterize the microstructures, mechanical, and electronic properties of bulk TaSi2 ceramics at HPHT conditions. Our results indicate an enhancement in the fracture toughness of 11.97 MPa m1/2 for TaSi2 ceramics. More importantly, the electrical conductivity (47.13 × 105 S/m) of TaSi2 ceramic is increased and verified by theoretical calculations. These findings provide crucial insights for future applications of TaSi2 and offer valuable avenues for the design and synthesis of advanced ceramic materials.
Influence of ion‐induced lattice stress and phase transition on the irradiation resistance of high‐entropy ceramics
Authors: He Jiabei , Song Mengshan , Yang Ming , Zhu Miaomiao 
Published: September 2023

AbstractThe influence of ion irradiation on intrinsic lattice stress and phase transition is closely related to the irradiation resistance of high‐entropy ceramics. In this study, the ion‐induced response of high‐entropy‐stabilized o‐(ZrHfTiSn)O2 ceramic was investigated under Au2+ irradiation with different fluences. The results revealed that high‐fluence irradiation caused the minimal (orthorhombic‐to‐triclinic) phase transformation underneath the ion‐induced amorphous layer via. fast fourier transformation (FFT) pattern. The cation recombination led to cation rearrangement followed by the increase of lattice expansion induced stress. The lattice stability of residual crystal grains in the mixed layer was significantly improved after lattice rearrangement. This was evidenced by the fact that the X‐ray diffraction profile of the lattice remained unchanged, whereas the selected area electron diffraction (SAED) image exhibited drastic variations with the increase of irradiation fluence. Therefore, irradiation‐induced lattice rearrangement seems to be a reliable way to improve radiation resistance of high‐entropy ceramics.
How and where does “care” fit within seminal life‐course approaches? A narrative review and critical analysis
Authors: Lawless Michael T. , Tieu Matthew , Golley Rebecca , Kitson Alison 
Published: September 2023

AbstractAimsTo map the concepts of the caring life‐course theory that are used in life‐course approaches from different disciplines; establish whether there is a common recognition of, or language used, to describe care in those life‐course approaches; and identify the role and contribution of care to the life‐course literature.DesignThis discursive paper uses a narrative review process to explore points of convergence and divergence between life‐course approaches and the caring life‐course theory.MethodsCategories for analysis were developed deductively and inductively, focusing on the constructs of fundamental care, capacity and capability, care network, care transition, care trajectory and care biography.ResultsWe identified four disciplinary perspectives: (1) life‐course sociology; (2) life‐course epidemiology; (3) lifespan developmental psychology; and (4) life‐course health development. While six core constructs of the caring life‐course theory were described, either explicitly or implicitly, in existing life‐course approaches, no single approach fully describes the role and contribution of care across the lifespan.ConclusionLife‐course approaches have largely neglected the contribution and role of care in informing the life‐course discourse. This review highlights the significance of care beyond traditional healthcare settings and recognizes it as a fundamental human need for well‐being and development, which can contribute to existing life‐course literature.Implication for the Profession and/or Patient CareThere is a need to understand care as a complex system and embrace a whole‐system, life‐course approach to enable nurses and other healthcare professionals to provide high‐quality, patient‐centred care.ImpactIncorporating care within a life‐course approach provides opportunities to integrate and deliver care centred around the person, their life transitions, trajectories and care networks, including informal carers and healthcare professionals.No Patient or Public ContributionPatients or members of the public were not involved in this study as it is a discursive paper based on the relevant literature.