bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pepper homeobox abscisic acid signalling‐related transcription factor 1, CaHAT1, plays a positive role in drought response
Authors: Baek Woonhee , Bae Yeongil , Lim Chae Woo , Lee Sung Chul 
Published: May 2023

AbstractAbscisic acid (ABA) signalling triggers drought resistance mediated by SNF1‐related kinase 2s (SnRK2s), which transmits stress signals through the phosphorylation of several downstream factors. However, these kinases and their downstream targets remain elusive in pepper plants. This study aimed to isolate interacting partners of CaSnRK2.6, a homologue of Arabidopsis SnRK2.6/OST1. Among the candidate proteins, we identified a homeodomain‐leucine zipper (HD‐Zip) class II protein and named it CaHAT1 (Capsicum
annuum
homeobox
ABA signalling related‐
transcription factor
1). CaHAT1‐silenced pepper and ‐overexpression (OE) transgenic Arabidopsis plants were generated to investigate the in vivo function of CaHAT1 in drought response. Following the application of drought stress, CaHAT1‐silenced pepper plants exhibited drought‐sensitive phenotypes with reduced ABA‐mediated stomatal closure and lower expression of stress‐responsive genes compared with control plants. In contrast, CaHAT1‐OE transgenic Arabidopsis plants showed the opposite phenotypes, including increased drought resistance and ABA sensitivity. CaHAT1, particularly its N‐terminal consensus sequences, was directly phosphorylated by CaSnRK2.6. Furthermore, CaSnRK2.6 kinase activity and CaSnRK2.6‐mediated CaHAT1 phosphorylation levels were enhanced by treatment with ABA and drought stress. Taken together, our results indicated that CaHAT1, which is the target protein of CaSnRK2.6, is a positive regulator of drought stress response. This study advances our understanding of CaHAT1–CaSnRK2.6 mediated defence mechanisms in pepper plants against drought stress.
Feminism and activism across borders: A roundtable
Authors: Florvil Tiffany N. , Marino Katherine M. , Siegel Mona L. 
Published: May 2023

AbstractThis roundtable explores women's and feminist activism and advocacy across borders over the past century. Invited by Peace & Change, the participants are experts in women's, gender, diasporic, transnational, and global history, and they bring their recent and current research to bear on the following questions.
Random dynamics and limiting behaviors for 3D globally modified Navier–Stokes equations driven by colored noise
Authors: Caraballo Tomás , Chen Zhang , Yang Dandan 
Published: May 2023

AbstractThis paper is mainly concerned with the long‐term random dynamics for the nonautonomous 3D globally modified Navier–Stokes equations with nonlinear colored noise. We first prove the existence of random attractors of the nonautonomous random dynamical system generated by the solution operators of such equations. Then we establish the existence of invariant measures supported on the random attractors of the underlying system. Random Liouville‐type theorem is also derived for such invariant measures. Moreover, we further investigate the limiting relationship of invariant measures between the above equations and the corresponding limiting equations when the noise intensity approaches to zero. In addition, we show the invariant measures of such equations with additive white noise can be approximated by those of the corresponding equations with additive colored noise as the correlation time of the colored noise goes to zero.
Class numbers, cyclic simple groups, and arithmetic
Authors: Cheng Miranda C. N. , Duncan John F. R. , Mertens Michael H. 
Published: May 2023

AbstractHere, we initiate a program to study relationships between finite groups and arithmetic–geometric invariants in a systematic way. To do this, we first introduce a notion of optimal module for a finite group in the setting of holomorphic mock Jacobi forms. Then, we classify optimal modules for the cyclic groups of prime order, in the special case of weight 2 and index 1, where class numbers of imaginary quadratic fields play an important role. Finally, we exhibit a connection between the classification we establish and the arithmetic geometry of imaginary quadratic twists of modular curves of prime level.
Effects of salt and stress on blood pressure parameters and antioxidant enzyme function in the heart and aorta of borderline hypertensive rats
Authors: Savić Bojana , Brkljačić Jelena , Glumac Sofija , Šarenac Olivera , Murphy David , Blagojević Duško , Japundžić‐Žigon Nina , Dušić Zorana Oreščanin 
Published: May 2023

AbstractHypertension and its complications are a leading cause of death in the human population. Several factors can contribute to development of hypertension, such as genetic predisposition, high salt intake and environmental stressors, underlying oxidative stress as one of its key trademarks. We studied the effects of increased salt intake and chronic stress on blood pressure parameters and the activity and protein levels of antioxidant enzymes in the heart and aorta of borderline hypertensive rats (BHRs) with genetic susceptibility to hypertension. All animals were randomized into four groups: (1) Wistar rats kept in baseline conditions; (2) BHRs kept in baseline conditions; (3) BHRs drinking 0.9% saline solution; and (4) BHRs drinking 0.9% saline solution and exposed to repeated heterotypic stress. The BHRs exhibited significantly higher blood pressure, mitochondrial superoxide dismutase (SOD2) and catalase (CAT) protein levels and lower glutathione peroxidase (GPx) and glutathione reductase (GR) activities in the aorta, followed by lower CAT and GPx protein levels and higher CAT and GR activities in the heart, compared with normotensive Wistar rats. In the BHR aorta, high salt intake elevated CAT and GPx activities, and when combined with stress it increased GPx and GR activities. In BHR hearts, high salt intake provoked lower CAT activity. Adding repeated stress to salt treatment further decreased CAT activity, in addition to Cu2+–Zn2+ superoxide dismutase (SOD1) and GR activities. The protein level of CAT was lower, whereas SOD2 and GPx increased. Overall, our results suggest that BHR hearts are better adapted to oxidative pressure, compared with the aorta, when exposed to salt and stress.
Combinational Framework for Classification of Bearing Faults in Rotating Machines
Authors: Kumar Sujit , Ganga D. 
Published: May 2023

Abstract
In rotating machines, roller bearings are important and prone to frequent faults. Hence, accurate classification of bearing faults is significant in the maintenance of machines. Toward this, a framework using the combination of signal processing, machine learning, and deep learning algorithms has been proposed in contrast to traditional approaches for the accurate identification of bearing faults. The benefits of each algorithm have been reaped in the proposed framework to overcome challenges met in fault identification. In this, ensemble empirical mode decomposition is applied on bearing vibration signals to reduce nonstationarity and noise. The 12 intrinsic mode function (IMF) signals of 24k length obtained for three bearing conditions at four different speeds constituted feature space of dimension [36*8*24,000]. IMFs that have the highest correlation coefficient with raw vibration signals are selected as features [3*8*24,000], and intelligent algorithms are applied. Application of principal component analysis on selected IMF feature space resulted in extraction of significant feature space retaining temporal characteristics along two major components [3*2*24,000]. Considering the temporal dependence of faults in signals, a stacked long short-term memory (LSTM) deep network is chosen and trained with extracted features to improve fault classification. The performance of this developed framework has been evaluated for different metrics of the stacked LSTM model. The proposed framework also satisfactorily surpassed the performance of the stacked LSTM model trained with raw data, capable of auto-feature learning. The comparative results inclusive of models in relevant literature illustrate the efficacy of developed combinational framework in handling dynamic vibration data for precise classification of bearing faults.
Dual Quaternions Representation of Lagrange's Dynamic Equations
Authors: Cohen Avraham , Taub Benjamin , Shoham Moshe 
Published: May 2023

Abstract
This paper introduces for the first time, the Lagrange's dynamic equations in dual number quaternion form. Additionally, Rayleigh's dissipation function in dual quaternion form is introduced here allowing for the accounting of dissipative (non-conservative) forces such as motion through a viscous fluid, friction, and spring damping force. As an example, dual quaternions are used here to derive the Lagrange dynamic equations of a robot manipulator.
Physical and cognitive impairments in people suffering from long COVID: protocol for a longitudinal population-based cohort study
Authors: Zahouani Imane , Desmeules François , Perreault Kadija , Campeau-Lecours Alexandre , Best Krista , Beaulieu-Bonneau Simon , Paquette Jean-Sébastien , Deslauriers Simon , Daigle Nicolas , Drouin Gilles , Tittley Jean , Gagnon Marie-Andrée , Salmam Imane , Brouillard Sarah-Maude , Lepage Katherine , Roy Jean-Sébastien 
Published: May 2023

IntroductionApproximately 33% of people who contracted COVID-19 still experience symptoms 12 weeks after infection onset. This persistence of symptoms is now considered a syndrome itself called ‘long COVID’. Evidence regarding long COVID and its cognitive and physical impacts is growing, but the literature is currently lacking objectively measured data to guide towards adapted healthcare trajectories. The objectives are to describe the physical and cognitive impairments experienced by individuals living with long COVID using self-reported and clinical objective measures, and to compare the evolution over time of the physical and cognitive state between adults living with long COVID (at least one physical or cognitive COVID-19 symptom for more than 12 weeks following infection; long COVID group), people who developed COVID-19 but did not experience persistent symptoms (short COVID group) and people who did not develop COVID-19 (control group).Methods and analysisIn this longitudinal cohort study, 120 participants will be recruited in each group. Variables will be collected through three evaluation sessions over 6 months (baseline, 3 months, 6 months). Variables include self-administered questionnaires on health-related quality of life, comorbidity, sleep, pain, anxiety, depressive symptoms, fatigue and cognitive function, as well as objective measures of cognitive (attention, memory, executive functioning) and physical (grip strength, balance, gait speed, gait endurance, VO2, frailty) functions. Activity, heart rate and sleep will be monitored with a fitness tracker watch for 7 days following evaluation sessions. Maximum-likelihood analyses of variance (ANOVAs) will be used to compare data at baseline between groups. Repeated measures ANOVAs will be used to compare the longitudinal performance variations across groups of the self-reported and clinical variables.Ethics and disseminationEthics committees of the CIUSSS de la Capitale-Nationale and CIUSSS de l’Est-de-l’Île-de-Montréal approved the project. Results will be disseminated through clinical and community platforms as well as through peer-reviewed manuscripts and international conferences.Trial registration numberNCT05216536.
Separate and combined effects of long-term GIP and GLP-1 receptor
activation in patients with type 2 diabetes: a structured summary of a study
protocol for a double-blind, randomised, placebo-controlled clinical
trial
Authors: Helsted Mads M , Gasbjerg Lærke S , Vilsbøll Tina , Nielsen Casper K , Forman Julie L , Christensen Mikkel B , Knop Filip K 
Published: May 2023

Introduction
Due to reports of severely reduced insulinotropic effect of the
incretin hormone glucose-dependent insulinotropic polypeptide (GIP) in
type 2 diabetes (T2D), GIP has not been considered therapeutically
viable. Recently, however, tirzepatide, a novel dual incretin receptor
agonist (activating the GIP receptor and the glucagon-like peptide 1
(GLP-1) receptor) has demonstrated greater glucose and body
weight-lowering properties as compared to GLP-1 receptor agonist
therapy. The contribution of GIP receptor activation to effects of
tirzepatide remains unknown. We will evaluate the glucose-lowering
effect of exogenous GIP in the context of pharmacological GLP-1 receptor
activation in patients with T2D.

Methods and analysis
In this randomised, double-blind, four-arm parallel,
placebo-controlled trial, 60 patients with T2D will be included (18–74
of age; on diet and exercise and/or metformin therapy only; glycated
haemoglobin 6.5–10.5% (48–91 mmol/mol)). Participants will be randomised
to an 8-week run-in period with subcutaneous (s.c.) placebo or
semaglutide injections once-weekly (0.5 mg). Participants will then be
randomised to 6 weeks’ add-on treatment with continuous s.c. placebo or
GIP infusion (16 pmol/kg/min). The primary endpoint is change in mean
glucose levels (assessed by 14-day continuous glucose monitoring) from
the end of the run-in period to end of trial.

Ethics and dissemination
The present study was approved by the Regional Committee on Health
Research Ethics in the Capitol Region of Denmark (identification no.
H-20070184) and by the Danish Medicines Agency (EudraCT no.
2020-004774-22). All results, positive, negative and inconclusive, will
be disseminated at national and/or international scientific meetings and
in peer-reviewed scientific journals.

Trial registration numbers
NCT05078255 and U1111-1259-1491.
Instruments for assessing quality policies and strategies in health systems: a scoping review protocol
Authors: Pellense Márcia Cunha da Silva , Gama Zenewton André da Silva 
Published: May 2023

IntroductionThe World Organization recommends to implement National Quality Policies and Strategies in health systems, but few instruments have been proposed to assess and monitor these quality interventions at the system level. This study will map and compare instruments for the assessment of quality policies and strategies in health systems around the world.Methods and analysisThis is a scoping review protocol developed according to the Joanna Briggs Institute’s manual and guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. The search for articles will be performed in the following Embase, Medline/Pubmed, Scopus, Web of Science and Cumulative Index to Nursing and Allied Health Literature. Searches will also be conducted on Google Scholar and grey literature (www.opengrey.eu). A descriptive analysis of studies mapped by analysis categories will be performed. The results will be presented through a narrative summary of the mapped findings to verify how the results correlate with the objective and research question of the review.Ethics and disseminationThe study does not require an ethical review due to its nature. The submission of results for publication in a peer-reviewed journal and presentation at a scientific conference is expected.Link to the protocol record in the Open Science Framework (OSF)https://DOI.org/10.17605/OSF.IO/2KMTS
Efficacy of a digital mental health intervention embedded in routine care compared with treatment as usual in adolescents and young adults with moderate depressive symptoms: protocol for randomised controlled trial
Authors: Szigethy Eva , Wolfson David , Sinclair-McBride Keneisha , Williams Kelly , Jhe Grace , Lee Erica H , Bialostozky Mario , Wallace Meredith , Bhatnagar Sonika , Demaso DR , Yealy Donald M , Hollenbach Kathryn 
Published: May 2023

IntroductionThere are unmet mental health needs of depressed adolescents and young adults (AYAs) across the USA. Behavioural technology adequately integrated into clinical care delivery has potential to improve care access and efficiency. This multisite randomised controlled trial evaluates how a coach-enhanced digital cognitive behavioural intervention (dCBI) enhances usual care for depressed AYAs in paediatric practices with minority enriched samples.Methods and analysisParticipants (n=750) ages 16–22 who meet threshold criteria for depressive severity (Patient Health Questionnaire-9; PHQ-9 score 10-24) will be recruited through paediatric practices across three academic institutions (Boston, Pittsburgh and San Diego). Participants will be randomised to 12 weeks of dCBI+treatment as usual (TAU) (n=450) or TAU alone (n=300) in outpatient paediatric practices. Assessments will be completed at baseline, 6 weeks and 12 weeks with the primary outcome being improvement in clinician-rated and self-reported depressive severity (Children’s Depression Rating Scale—Revised and PHQ-9) and secondary outcomes being self-reported suicidal ideation (item 9 on PHQ-9), anxiety severity (Generalised Anxiety Disorder), general quality of life (Satisfaction with Life Scale) and general functioning (Children’s Global Assessment Scale). The study design is an intent-to-treat mixed effects regression with group, and covariates nested within the sites.Ethics and disseminationAll participants or their parent/guardian (under 18 years or unemancipated) will give informed consent to a study team member. All data are expected to be collected over 18 months. The Institutional Review Board (IRB) is a board at each institution in the United States that reviews and monitors research involving human subjects. IRB approval from the University of Pittsburgh was obtained on 30 November 2021 (STUDY21080150), from the University of California San Diego’s Human Research Protection Program IRB on 14 July 2022 (802047), and from the Boston Children’s Hospital IRB on 25 October 2022 (P00040987). Full study results are planned to be published within 2 years of initial study recruitment (October 2024). Dissemination of findings will occur in peer-reviewed journals, professional conferences and through reports to participating entities and stakeholders.Trial registration numberNCT05159713; ClinicalTrials.gov
Dose and administration time of indocyanine green in near-infrared fluorescence cholangiography during laparoscopic cholecystectomy (DOTIG): study protocol for a randomised clinical trial
Authors: López-Sánchez Jaime , Garrosa-Muñoz Sonsoles , Pardo Aranda Fernando , Gené Škrabec Clara , López Pérez Ricardo , Rodríguez-Fortúnez Patricia , Sánchez Santos José Manuel , Muñoz-Bellvís Luis 
Published: May 2023

BackgroundOne of the most severe complications in laparoscopic cholecystectomy (LC) is intraoperative bile duct injury (BDI). Despite its low incidence, the medical implications for the patient can be serious. Besides, BDI can also generate significant legal issues in healthcare. Different techniques have been described to reduce the incidence of this complication, and near-infrared fluorescence cholangiography with indocyanine green (NIRFC-ICG) is one of the latest additions. In spite of the great interest aroused by this procedure, there are currently great disparities in the usage or administration protocols of ICG.Methods and analysisThis is a randomised, multicentre, per-protocol analysis, open clinical trial with four arms. The estimated duration of the trial is 12 months. The aim of the study is to analyse whether there are differences between the dose and administration ICG intervals to obtain good-quality NIRFC during LC. The primary outcome is the degree of identification of critical biliary structures during LC. In addition, different factors will be analysed that may have an influence on the results of this technique.Ethics and disseminationThe trial will be conducted according to the recommendations for Clinical Trials in the Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects and the recommendations of the Spanish Agency of Medicines and Medical Devices (AEMPs) for clinical trials. This trial was approved by the local institutional Ethics Committee and the AEMPs. The results of the study will be presented to the scientific community through publications, conferences or other means.EudraCT number2022-000904-36.Protocol versionV.1.4, 2 June 2022Trial registration numberNCT05419947.
Experience of enhanced near-peer support for new medical graduates of an Irish university: a phenomenological study
Authors: Coakley Niamh , Wiese Anel , O'Leary Paula , Bennett Deirdre 
Published: May 2023

ContextFactors contributing to the stressful transition from student to doctor include issues with preparedness for practice, adjusting to new status and responsibility, and variable support. Existing transitional interventions provide inconsistent participation, responsibility and legitimacy in the clinical environment. Enhanced support by near peers for new doctors may ease the transition. Irish medical graduates of 2020 commenced work early, creating an unprecedented period of overlap between new graduates and the cohort 1 year ahead.ObjectiveTo explore the experience of commencing practice for these new doctors with this increased near-peer support.DesignWe used interpretive phenomenological analysis as our methodological approach, informed by the cognitive apprenticeship model, to explore the experience of enhanced near-peer support at the transition to practice. Participants recorded audio diaries from their commencement of work, and a semistructured interview was conducted with each, after 3 months, concerning their experience of their overlap with the previous year’s interns.SettingUniversity College Cork, one of six medical schools in Ireland.ParticipantsNine newly qualified medical doctors.Main outcome measuresAn exploration of their experience of transition to clinical practice, in the context of this enhanced near-peer support, will inform strategies to ease the transition from student to doctor.ResultsParticipants felt reassured by having a near-peer in the same role and safe to seek their support. This empowered them to gradually assume increasing responsibility and to challenge themselves to further their learning. Participants perceived that commencing work before the annual change-over of other grades of doctor-in-training enhanced their professional identities and improved patient safety.ConclusionsEnhanced near-peer support for new doctors offers a potential solution to the stressful transition to practice. Participants were legitimate members of the community of practice, with the status and responsibility of first-year doctors. Furthermore, this study reinforces the benefit of asynchronous job change-over for doctors-in-training.