bluuebunny/crossref_metadata_2025_split huggingface dataset:
Further Thoughts on Measuring Narrational Complexity in Fiction Film
Authors: Magliano Joseph P. , Luan Lingfei , Allen Laura 
Published: March 2023

Abstract
Cutting (2021) argues that the narrational complexity of fiction film can be quantified similarly to computational measures of text complexity. Narrational complexity refers to the structure that arises from how a story is told. This article expands upon Cutting's proposal by taking inspiration from contemporary approaches for measuring text complexity. These approaches reject the notion that complexity can be measured via a limited set of indices as Cutting proposed for narrational complexity. Similarly, we argue that narrational complexity for fiction films should be multi-dimension and include indices that are associated with events, characters, and the rules that govern the fictional world. We discuss the viability of using computational approaches to analyze video and natural language processing to develop approaches to measuring narrational complexity.
Substantiation of the effectiveness of osteopathic correction in the treatment of patients suffering from post-puncture syndrome
Authors: Krivenya M. S. , Gorobets L. V. 
Published: March 2023

Introduction. Post-puncture syndrome (PPS) is a complex of symptoms that occurs 1–2 days after spinal anesthesia or lumbar puncture, and the headache is a leading symptom. Currently, there is no effective method of non-invasive treatment of PPS. Based on the possible role of dura mater damage in the PPS pathogenesis, it is reasonable to assume that the identification and osteopathic correction of somatic dysfunctions in the respective regions may be effective in the treatment of patients suffering from PPS.The aim of the study is to substantiate the possibility of using osteopathic correction in the treatment of patients suffering from post-puncture syndrome.Materials and methods. The study involved 40 patients with PPS syndrome aged 20 to 50 years who were hospitalized after surgery with spinal anesthesia using. Patients were randomized into two groups — control (20 patients) and main (20 patients). All study participants were prescribed bed and medium drinking (25–30 ml/kg body weight) regimen. Participants of the main group additionally received a single hour session of osteopathic correction on the first day after the operation. All patients were examined at the start of treatment and on the third day after the start of a treatment. The severity of pain was assessed using a visual analogue scale (VAS, from 0 to 10 points), the severity of PPS and the osteopathic status.Results. Patients suffering from PPS are characterized by the presence of intense pain syndrome (5–6 points according to VAS); they are characterized by a headache that worsens during taking a vertical position and is accompanied by dizziness and nausea. These patients are characterized by the presence of biomechanical disorders in the regions of the head, dura mater, lower extremities and neck (structural component). The use of osteopathic correction is accompanied by a statistically significant (p<0,05) decrease in the pain syndrome intensity, relief of PPS symptoms, and a decrease in the detection frequency of the most regional somatic dysfunctions.Conclusion. Based on the results obtained, it seems possible to recommend the inclusion of osteopathic correction in the complex of therapeutic measures for patients suffering from PPS.
Osteopathic rehabilitation of patients after community-acquired pneumonia
Authors: Usupbekova B. Sh. , Sartmyrzaeva S. S. , Murzakhmetova Sh. A. 
Published: March 2023

Introduction. During the COVID-19 pandemic, the effective medical rehabilitation of patients who have suffered community-acquired pneumonia is crucial, and the osteopathic correction can take its rightful place along with other rehabilitation methods. The studies of osteopathic approaches in the treatment of pneumonia are described in available sources for the inpatient stay of patients. The issues of the effectiveness of osteopathic correction in more distant periods of rehabilitation after community-acquired pneumonia are poorly covered and therefore became the basis for the presented work.The aim of the study is to research the effectiveness of the osteopathic correction inclusion in the outpatient rehabilitation program for patients after community-acquired pneumonia.Materials and methods. A prospective, controlled, randomized study was conducted at the Clinic of the Eurasian Institute of Osteopathic Medicine (Bishkek, Kyrgyz Republic) from January to June 2021. 30 patients who have suffered community-acquired pneumonia of mild and moderate severity were examined, including 15 people of the main group who received osteopathic correction every 7 days for 3–4 weeks and simultaneously performed the recommended set of exercises of physical therapy (exercise therapy); 15 people of the control group, without osteopathic correction, only a set of exercise therapy exercises was recommended for these patients. The evaluation of the effectiveness of osteopathic correction was carried out on the basis of the analysis of spirometry, pulse oximetry, functional tests of the Stange and Genchi, and the life quality by the MOS SF-36 questionnaire.Results. The study showed that the inclusion of osteopathic correction in the rehabilitation of patients who have suffered community-acquired pneumonia signiﬁcantly (p<0,05) improves the indicators of the external respiration function, namely, the vital capacity of the lungs, increases the body′s resistance to hypoxia and hypercapnia, and improves the life quality.Conclusion. The obtained results allow us to reasonably recommend the inclusion of osteopathic correction in outpatient rehabilitation programs for patients who have suffered community-acquired pneumonia.
Resilience for Better Sustainability. ISO 28000: 2022 vs 2007. Comparative Analysis
Authors: Prazian M. 
Published: March 2023

ISO 28000:2022 “Security and Resilience — Security Management Systems — Requirements” is the second edition management system standard that supersedes the first edition (ISO 28000:2007, “Security Management Systems for the Supply Chain”). Both standards include aspects relevant to the supply chain; however, the incumbent (28000:2022) standard omitted notification about the supply chain in the title. So authors are interested in the reason for the accentuation shift as a necessary standard.
The article argues that Resilience now comes to the fore because of poly-crises in the world and Ukraine. It causes the rethinking and balancing actions for many aspects of Resilience and security based on the United Nations Sustainable Development Goals (2015), EU Green and Tweens transition (2019), and Paris Agreement (2015), and a paradigm shift from short-term to long-term values to ensure environmental, social, and governance (ESG) externalities for better Sustainability and Resilience.
In Ukraine, DSTU ISO 28000:2008, “Security Management Systems for the Supply Chain” will become obsolete in 2025. After the revision, ISO 28000:2022 covers all aspects of organizations much beyond the supply chain noted in ISO 28002:2011, “Security management systems for the supply chain — Development of resilience in the supply chain — Requirements with guidance for use”.
The author engages in prioritizing implementing ISO 28000:2022 in Ukraine. That is especially important to the nuclear industry with a complicated and safety-significant supply chain.
Penyuluhan Gaya Hidup Aktif bagi Anak Remaja sebagai Upaya Menghadapi Dampak Negatif Era Digital
Authors: Anam Khoiril , Soegiyanto Soegiyanto , Indardi Nanang , Baitul Mukarromah Siti , Wahidi Ribut , Muhtarom Didi , Nurdiansyah Dani 
Published: March 2023

Tujuan dengan diadakannya pengabdian ini adalah menyadarkan masyarakat akan bahaya efek negatif era digital bagi anak-anak usia remaja. Tim pengabdi menawarkan solusi dengan melakukan penyuluhan gaya hidup aktif melalui aktivitas fisik yang menyenangkan bagi anak usia remaja. Hal ini dilakukan untuk menyadarkan kepada anak-anak usia remaja bahwa pentingnya gaya hidup aktif dan bahaya jangka panjang gaya hidup pasif (sedentary).
Metode yang digunakan dalam pengabdian ini adalah menggunakan metode ceramah melalui zoom meeting. Hal ini dilakukan untuk menjaga kesehatan dan keselamatan peserta penyuluhan ini akibat pandemi covid-19. Peserta dalam penyuluhan ini adalah siswa SMP IT Nusantara Kembang Kabupaten Jepara yang berjumlah 143 orang yang mengikuti zoom meeting.
Penyuluhan dilakukan dengan memberikan materi tentang gaya hidup aktif melalui aktivitas fisik yang menyenangkan. Hal ini sesuai dengan tema pengabdian kepada masyarakat yaitu untuk menghadapi dampak negatif era digital yaitu salah satunya gaya hidup pasif, yang nantinya dapat menimbulkan dampak negatif terhadap kesehatan. Gaya hidup aktif dapat diartikan dengan gaya hidup yang memperhatikan gerak dalam keseharaiannya, baik itu aktivitas fisik ataupun olahraga. Karena keduanya memiliki manfaat terhadap kesehatan seseorang.
Fine Needle Aspiration Cytology of Thyroid Swellings With Histopathological Corellation
Authors: Das Sanjoy , Datta Pranay Kumar , Shari Sayed Muhammad Alauddin , Hossain Mohammed Shoaib 
Published: March 2023

Background : To assess the diagnostic accuracy of aspiration cytology as a pre-operative screening procedure and this study was done to reach a consensus and to find out the best diagnostic tool for assessment of thyroid swellings pre-operatively.
Materials and methods : A cross sectional study was carried out in the Department of Otolaryngology & Head Neck Surgery of Chittagong Medical College Hospital (CMCH) between March 2014 to March 2015. Total 50 patients were included in the study, where pre-operative Fine Needle Aspiration Cytology (FNAC) and post operative histopathology were done to find out the correlation. Data were analyzed and presented as both qualitative and quantitative data as applicable using SPSS version 20. The quantitative data were analyzed by mean, standard deviation. The qualitative data were analyzed by Mc NEMAR test (Mc NEMAR c2 test).
Results : 50 cases were included in the study. FNAC revealed 40 non- neoplastic lesion, 5 papillary carcinoma, 4 follicular neoplasm and 1 was suspicious for malignancy. Histopathology revealed 38 non neoplastic and 2 neoplatic lesion among 40 non neoplastic cases. 5 cases which were diagnosed as papillary carcinoma thyroid on FNAC were also proved to be same on histopathology. Out of 4 follicular neoplasm 1 was non neoplastic and other 3 were neoplstic. The suspicious for malignancy lesion was proved as cystic papillary carcinoma on histopathology. The sensitivity of FNAC was 81.82%, specificity was 97.44%, positive predictive value was 90%, negative predictive value was 95% and accuracy was 94%.
Conclusion : FNAC of Thyroid is more specific then sensitive with high accuracy rate. Therefore FNAC should be adopted as an initial investigation of thyroid disease.
JCMCTA 2019 ; 30 (2) : 36-40
Efficacy of Lignocaine in Three Different Routes In Attenuation of Haemodynamic Response Associated With Endotracheal Intubation : A Comparative Study
Authors: Chowdhury Ahmed Abu Naser , Alam A K M Shamsul , Chowdhury Gulshan Ara 
Published: March 2023

Background: Transient haemodynamic instability i.e tachycardia and hypertension is an inevitable outcome of laryngoscopy and endotracheal intubation which can have serious effects in patients with COPD, IHD or hypertension that can lead to ischaemia, infarction, arrhythmia or cardiac arrest in vulnerable patients. Administration of lignocaine is one of the techniques used to attenuate haemodynamic response associated with endotracheal intubation. The present study was designed to compare the changes in blood pressure and heart rate that occur before and after the endotracheal intubation in three different routes intravenous( i.v.) local spray over laryngeal inlet or nebulization.
Materials and methods : It was a randomized double blind clinical trial. It was conducted at the Department of Anaesthesiology, Chittagong Medical College Hospital, Chattogram from July 2005 to June 2007. A total of one hundred and fifty adult patients (ASA I, Mallampati grade 1 & 2) scheduled for elective surgery under general anaesthesia wereselected. Patients were randomly allocated in three groups A,B and C, by lottery .Group A received 2% lignocaine i.v., Group B received 10% lignocaine spray over the laryngeal inlet and vocal cords and group C patients were nebulized with 2% lignocaine solution.
Results: The rise in Systolic, Diastolic and mean arterial pressure with local spray was significantly lower than with intravenous and nebulized group and the rise in heart rate was significantly lower with local spray group than with nebulization group and intravenous group. Data were processed using software SPSS version 11.5. The test statistics used to analyse the data were Chi-squire(c2) test and Anova.
Conclusion: The findings of this study reflects the local spray of 10% lignocaine over laryngeal inlet prior to intubations attenuates the rise in blood pressure and heart rate more than intravenous administration of lignocaine or nebulization of lignocaine.
JCMCTA 2019 ; 30 (2) : 86-91
Application of the thrombin generation assay in patients with antiphospholipid syndrome: A systematic review of the literature
Authors: Gehlen Rachel , Vandevelde Arne , de Laat Bas , Devreese Katrien M. J. 
Published: March 2023

BackgroundThe antiphospholipid syndrome (APS) is classified by the presence of antiphospholipid antibodies (aPL) and thrombotic and/or adverse obstetric outcomes. The diagnosis and risk assessment of APS is challenging. This systematic review investigated if the thrombin generation (TG) assay could be helpful for APS diagnosis and risk assessment.MethodsA systemic review was performed by searching two databases (MEDLINE and Embase) until March 31, 2022, using a search strategy with two concepts: APS and TG, and related keywords. Two reviewers independently screened the articles based on predefined inclusion and exclusion criteria. Data extraction and quality assessment with the Newcastle-Ottawa Scale (NOS) were performed independently. Synthesis Without Meta-analysis guidelines were followed for data synthesis reporting.ResultsFourteen studies with 677 APS and 1,349 control subjects were included with variable quality according to the NOS. Twelve studies measured TG via the calibrated automated thrombogram (CAT) method using a fluorogenic substrate, whereas two used a chromogenic substrate-based TG assay. One study compared the CAT assay to the fully-automated ST Genesia® (Stago, France). Two studies initiated TG using platelet-rich plasma, whereas the rest of the studies used platelet-poor plasma. Resistance to activated protein C (aPC) was examined in ten studies. They reported a significant increase in aPC-resistance in APS patients compared to healthy controls, aPL-carriers, and thrombotic controls. Based on two studies, the prevalence of aPC-resistance was higher in APS patients compared to healthy controls and thrombotic controls with odds ratios of 5.9 and 6.8–12.8, respectively (p &lt; 0.05). In contrast, no significant difference in aPC-resistance was found between APS patients and autoimmune disease controls. Furthermore, 7/14 studies reported TG-parameters including peak height, endogenous thrombin potential, lag time, and time to peak, but these outcomes were highly variable between studies. Furthermore, TG methodology between studies differed greatly, impacting the comparability of the studies.ConclusionaPC-resistance measured with TG was increased in APS patients compared to healthy and thrombotic controls, but the diagnostic and prognostic value is unclear compared to current diagnostic strategies. Studies of other TG-parameters were heterogeneous and more research is needed to identify their potential added value in APS diagnosis.Systematic Review Registrationhttps://www.PROSPERO/, identifier: CRD42022308363
Early growth response-1: Key mediators of cell death and novel targets for cardiovascular disease therapy
Authors: Xie Yixin , Li Yongnan , Chen Jianshu , Ding Hong , Zhang Xiaowei 
Published: March 2023

SignificanceCardiovascular diseases are seen to be a primary cause of death, and their prevalence has significantly increased across the globe in the past few years. Several studies have shown that cell death is closely linked to the pathogenesis of cardiovascular diseases. Furthermore, many molecular and cellular mechanisms are involved in the pathogenesis of the cardiac cell death mechanism. One of the factors that played a vital role in the pathogenesis of cardiac cell death mechanisms included the early growth response-1 (Egr-1) factor.Recent AdvancesStudies have shown that abnormal Egr-1 expression is linked to different animal and human disorders like heart failure and myocardial infarction. The biosynthesis of Egr-1 regulates its activity. Egr-1 can be triggered by many factors such as serum, cytokines, hormones, growth factors, endotoxins, mechanical injury, hypoxia, and shear stress. It also displays a pro-apoptotic effect on cardiac cells, under varying stress conditions. EGR1 mediates a broad range of biological responses to oxidative stress and cell death by combining the acute changes occurring in the cellular environment with sustained changes in gene expression.Future DirectionsThe primary regulatory role played by the Egr-1-targeting DNAzymes, microRNAs, and oligonucleotide decoy strategies in cardiovascular diseases were identified to provide a reference to identify novel therapeutic targets for cardiovascular diseases.
Gene signature and prediction model of the mitophagy-associated immune microenvironment in renal ischemia-reperfusion injury
Authors: Chen Ruo-Yang , Li Da-Wei , Xie Hui , Liu Xiao-Wen , Zhuang Shao-Yong , Wu Hao-Yu , Wu Jia-Jin , Sun Nan , Qu Jun-Wen , Miao Jia-Yi , Zhong Chen , Huang Yu-Hua , Yuan Xiao-Dong , Zhang Ming , Zhang Wei-Jie , Hou Jian-Quan 
Published: March 2023

BackgroundRenal ischemia-reperfusion injury (IRI) is an inevitable occurrence during kidney transplantation. Mitophagy, ferroptosis, and the associated immune microenvironment (IME) have been shown to play important roles in renal IRI. However, the role of mitophagy-associated IME genes in IRI remains unclear. In this study, we aimed to construct a prediction model of IRI prognosis based on mitophagy-associated IME genes.MethodThe specific biological characteristics of the mitophagy-associated IME gene signature were comprehensively analyzed using public databases such as GEO, Pathway Unification, and FerrDb. Correlations between the expression of prognostic genes and immune-related genes and IRI prognosis were determined by Cox regression, LASSO analysis, and Pearson’s correlation. Molecular validation was performed using human kidney 2 (HK2) cells and culture supernatant as well as the serum and kidney tissues of mice after renal IRI. Gene expression was measured by PCR, and inflammatory cell infiltration was examined by ELISA and mass cytometry. Renal tissue damage was characterized using renal tissue homogenate and tissue sections.ResultsThe expression of the mitophagy-associated IME gene signature was significantly correlated with IRI prognosis. Excessive mitophagy and extensive immune infiltration were the primary factors affecting IRI. In particular, FUNDC1, SQSTM1, UBB, UBC, KLF2, CDKN1A, and GDF15 were the key influencing factors. In addition, B cells, neutrophils, T cells, and M1 macrophages were the key immune cells present in the IME after IRI. A prediction model for IRI prognosis was constructed based on the key factors associated with the mitophagy IME. Validation experiments in cells and mice indicated that the prediction model was reliable and applicable.ConclusionWe clarified the relationship between the mitophagy-related IME and IRI. The IRI prognostic prediction model based on the mitophagy-associated IME gene signature provides novel insights on the prognosis and treatment of renal IRI.
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Authors: Hurler Lisa , Szilágyi Ágnes , Mescia Federica , Bergamaschi Laura , Mező Blanka , Sinkovits György , Réti Marienn , Müller Veronika , Iványi Zsolt , Gál János , Gopcsa László , Reményi Péter , Szathmáry Beáta , Lakatos Botond , Szlávik János , Bobek Ilona , Prohászka Zita Z. , Förhécz Zsolt , Csuka Dorottya , Kajdácsi Erika , Cervenak László , Kiszel Petra , Masszi Tamás , Vályi-Nagy István , Würzner Reinhard ,   Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Lyons Paul A. , Toonen Erik J. M. , Prohászka Zoltán 
Published: March 2023

IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through different pattern recognition molecules, including mannan binding lectin (MBL), a protein shown to interact with SARS-CoV-2 proteins. However, the exact role of lectin pathway activation and its key pattern recognition molecule MBL in COVID-19 is still not fully understood.MethodsWe therefore investigated activation of the lectin pathway in two independent cohorts of SARS-CoV-2 infected patients, while also analysing MBL protein levels and potential effects of the six major single nucleotide polymorphisms (SNPs) found in the MBL2 gene on COVID-19 severity and outcome.ResultsWe show that the lectin pathway is activated in acute COVID-19, indicated by the correlation between complement activation product levels of the MASP-1/C1-INH complex (p=0.0011) and C4d (p&lt;0.0001) and COVID-19 severity. Despite this, genetic variations in MBL2 are not associated with susceptibility to SARS-CoV-2 infection or disease outcomes such as mortality and the development of Long COVID.ConclusionIn conclusion, activation of the MBL-LP only plays a minor role in COVID-19 pathogenesis, since no clinically meaningful, consistent associations with disease outcomes were noted.
Design and performance of a 3D-Printed magnetorheological fluid-based adaptive vibration isolator
Authors: Choi Young T. , Yoo Byungseok , Park Jungjin , Pines Darryll J. , Wereley Norman M. 
Published: March 2023

Emerging additive manufacturing (or 3D printing) can be advantageous for developing magnetorheological fluid (MRF)-based vibration isolators (MRVIs) because their designs can be easily and efficiently customized and also in-situ fabrication and repairing can be possible. In this study, a simple and compact adaptive MRVI was fabricated by using a 3D printing method. A masked stereolithography (MSLA) 3D printer was used for the fabrication of the rubber bellow and plastic lid parts of the MRVI. The electromagnet was mounted onto the lid, the reservoir was filled with an MRF, and the lid was simply assembled with the reservoir using a 3D-printed large thread without traditionally machined components. Using a material testing machine, the damper forces of the 3D-printed MRVI were measured under a constant velocity loading condition for different magnetic fields. From these tests, the magnetic field-controllable performances of the MRVI such as the MR yield force, the dynamic force range, the dissipated energy, and the secant stiffness were obtained. For the evaluation of the long-term performance reliability of the MRVI due to the MRF sedimentation, its magnetic field-controllable performances were tracked for 156 days with the variable testing intervals. Finally, the feasibility of the 3D-printed MRVI was experimentally confirmed.