bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphodynamic Resilience of the Tide‐Dominated Estuary With Interference From Tidal Flat Reclamations
Authors: Zhang Min , Wu Hangxing , Dai Zhijun , Mi Jie , Cai Huayang 
Published: March 2023

AbstractMost tide‐dominated estuaries worldwide are among the morphodynamic shrinking types heavily disturbed by anthropogenic interventions like embankments and reclamations. A typical example is North Branch (NB), the northern first‐order distributary of Yangtze (Changjiang) Estuary, showed a rapid alteration from river‐dominated to tide‐dominated character in less than 50 years after intensive reclamations, resulting in serious morphodynamic shrinkage, thus attracted great concern of its evolutionary fate. Here, we explored this issue based on historical bathymetry data and hydro‐morphodynamic modeling to examine the morphology‐hydrology interactions and the suggested equilibrium re‐adjustment mechanism after intensive reclamations. Results demonstrated a mechanism of geomorphological resilience for the tide‐dominated estuary, evolving from preliminary estuarine shrinking to dynamic equilibrium after reclamations. Although reclamation could destabilize the system, leading to temporary positive feedback between tidal pumping and morphology shrinking, driving the estuary vanishing quickly in a short time. A substantial loss in the intertidal areas, changing the estuary geometry from a highly‐curved bank to a highly‐constrained channel, weakened flood tidal asymmetry of NB, which in turn altered sediment dynamics from deposition to erosion. Such negative feedback process tends to drive the estuary toward a new dynamic equilibrium morphology. The discovered nonlinear feedback mechanism is supported by the evidence of system efficiency adjustment, which was substantially gained during the first 30 years, then stayed in a low entropy production and minimum work state, indicating a more efficient dynamic equilibrium. If further estuary preservation policies are implemented, the dynamic equilibrium of NB is expected to continue for a long time in the future.
The Late Miocene‐Early Pliocene Biogenic Bloom: An Integrated Study in the Tasman Sea
Authors: Gastaldello M. E. , Agnini C. , Westerhold T. , Drury A. J. , Sutherland R. , Drake M. K. , Lam A. R. , Dickens G. R. , Dallanave E. , Burns S. , Alegret L. 
Published: March 2023

AbstractThe Late Miocene‐Early Pliocene Biogenic Bloom (∼9–3.5 Ma) was a paleoceanographic phenomenon defined by anomalously high accumulations of biological components at multiple open ocean sites, especially in certain regions of the Indian, and Pacific oceans. Its temporal and spatial extent with available information leaves fundamental questions about driving forces and responses unanswered. In this work, we focus on the middle part of the Biogenic Bloom (7.4–4.5 Ma) at International Ocean Discovery Program Site U1506 in the Tasman Sea, where we provide an integrated age model based on orbital tuning of the Natural Gamma Radiation, benthic foraminiferal oxygen isotopes, and calcareous nannofossil biostratigraphy. Benthic foraminiferal assemblages suggest changes in deep water oxygen concentration and seafloor nutrient supply during generally high export productivity conditions. From 7.4 to 6.7 Ma, seafloor conditions were characterized by episodic nutrient supply, perhaps related to seasonal phytoplankton blooms. From 6.7 to 4.5 Ma, the regime shifted to a more stable interval characterized by eutrophic and dysoxic conditions. Combined with seismic data, a regional change in paleoceanography is inferred at around 6.7 Ma, from stronger and well‐oxygenated bottom currents to weaker, oxygen‐depleted bottom currents. Our results support the hypothesis that the Biogenic Bloom was a complex, multiphase phenomenon driven by changes in ocean currents, rather than a single uniform period of sustained sea surface water productivity. Highly resolved studies are thus fundamental to its understanding and the disentanglement of local, regional, and global imprints.
3D Geophysical and Geological Modeling of the South Orkney Microcontinent (Antarctica): Tectonic Implications for the Scotia Arc Development
Authors: Morales‐Ocaña Cecilia , Bohoyo Fernando , Escutia Carlota , Marín‐Lechado Carlos , Rey‐Moral Carmen , Druet María , Galindo‐Zaldívar Jesús , Maestro Adolfo 
Published: March 2023

AbstractThe opening of the Scotia Arc resulted in the final breakup of the land bridge between South America and the Antarctic Peninsula. The South Orkney Microcontinent (SOM) constituted part of this former connection and it is now the largest continental block in the Southern Scotia Arc. We present the first 3D model of the SOM that, given its strategic position and characteristics, allows us to advance the knowledge of the tectonic processes involved in the development of the Scotia Arc. Due to the scarcity of reliable geological data, the initial approximation of the deep structure of the SOM was supported by the calculation of three main geological boundaries from geophysical data: the acoustic basement, the boundary of the magnetic anomaly source and the Moho depth. The 3D model was built, refined and validated by forward modeling and joint inversion of gravity and magnetic data. We have accurately defined the geometry of the sedimentary cover, determined the geometry of the intrusive igneous body causing the Pacific Margin Anomaly (PMA) and mapped the heterogeneity of the crustal thickness. These structural features show a clear relationship to each other and are consistent with an important E‐W extension to the east of the SOM during early stages of the Scotia Arc formation, prior to the opening of the Powell Basin.
Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions
Authors: Gulati Karan , Ding Chengye , Guo Tianqi , Guo Houzuo , Yu Huajie , Liu Yan 
Published: March 2023

AbstractNano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic burden associated with craniofacial defects, including traumas and tumours. Critical to the success of such nano-engineered non-resorbable craniofacial implants include load-bearing functioning and survival in complex local trauma conditions. Further, race to invade between multiple cells and pathogens is an important criterion that dictates the fate of the implant. In this pioneering review, we compare the therapeutic efficacy of nano-engineered titanium-based craniofacial implants towards maximised local therapy addressing bone formation/resorption, soft-tissue integration, bacterial infection and cancers/tumours. We present the various strategies to engineer titanium-based craniofacial implants in the macro-, micro- and nano-scales, using topographical, chemical, electrochemical, biological and therapeutic modifications. A particular focus is electrochemically anodised titanium implants with controlled nanotopographies that enable tailored and enhanced bioactivity and local therapeutic release. Next, we review the clinical translation challenges associated with such implants. This review will inform the readers of the latest developments and challenges related to therapeutic nano-engineered craniofacial implants.
Programmable protein delivery with a bacterial contractile injection system
Authors: Kreitz Joseph , Friedrich Mirco J. , Guru Akash , Lash Blake , Saito Makoto , Macrae Rhiannon K. , Zhang Feng 
Published: March 2023

AbstractEndosymbiotic bacteria have evolved intricate delivery systems that enable these organisms to interface with host biology. One example, the extracellular contractile injection systems (eCISs), are syringe-like macromolecular complexes that inject protein payloads into eukaryotic cells by driving a spike through the cellular membrane. Recently, eCISs have been found to target mouse cells1–3, raising the possibility that these systems could be harnessed for therapeutic protein delivery. However, whether eCISs can function in human cells remains unknown, and the mechanism by which these systems recognize target cells is poorly understood. Here we show that target selection by the Photorhabdus virulence cassette (PVC)—an eCIS from the entomopathogenic bacterium Photorhabdus asymbiotica—is mediated by specific recognition of a target receptor by a distal binding element of the PVC tail fibre. Furthermore, using in silico structure-guided engineering of the tail fibre, we show that PVCs can be reprogrammed to target organisms not natively targeted by these systems—including human cells and mice—with efficiencies approaching 100%. Finally, we show that PVCs can load diverse protein payloads, including Cas9, base editors and toxins, and can functionally deliver them into human cells. Our results demonstrate that PVCs are programmable protein delivery devices with possible applications in gene therapy, cancer therapy and biocontrol.
Chromosome-level genome assembly of the critically endangered Baer’s pochard (Aythya baeri)
Authors: Zhang Lei , Gao Xiaodong , Xia Tian , Yang Xiufeng , Sun Guolei , Zhao Chao , Liu Guangshuai , Zhang Honghai 
Published: March 2023

AbstractBaer’s pochard (Aythya baeri) is a critically endangered species historically widespread throughout East Asia, whose population according to a recent estimate has decreased to between 150 and 700 individuals, and faces a long-term risk of extinction. However, the lack of a reference genome limits the study of conservation management and molecular biology of this species. We therefore report the first high-quality genome assembly of Baer’s pochard. The genome has a total length of 1.14 Gb with a scaffold N50 of 85,749,954 bp and a contig N50 of 29,098,202 bp. We anchored 97.88% of the scaffold sequences onto 35 chromosomes based on the Hi-C data. BUSCO assessment indicated that 97.00% of the highly conserved Aves genes were completely present in the genome assembly. Furthermore, a total of 157.06 Mb of repetitive sequences were identified and 18,581 protein-coding genes were predicted in the genome, of which 99.00% were functionally annotated. This genome will be useful for understanding Baer’s pochard genetic diversity and facilitate the conservation planning of this species.
Study of the solid–gas–stress coupling model and its application
Authors: Shi Xianzhi , Song Dazhao 
Published: March 2023

AbstractCoal mines may change from non-outburst mines into coal and gas outburst mines with increasing mining depth. Therefore, scientific and rapid prediction of the coal seam outburst risk and effective prevention and control measures could ensure coal mine safety and production. This study aimed to propose a solid–gas–stress coupling model and assessed its applicability in predicting the coal seam outburst risk. Based on a large amount of outburst case data and the research results of previous scholars, coal and coal seam gas constitute the material basis of outbursts, and gas pressure is the energy source of coal seam outbursts. A solid–gas–stress coupling model was proposed, and a solid–gas–stress coupling equation was established via regression. Among the three major outburst factors, the sensitivity to the gas content during outbursts was the lowest. The causes of coal seam outbursts with a low gas content and the effect of the structure on outbursts were explained. It was theoretically revealed that the coupling of the coal firmness coefficient, gas content and gas pressure determined whether coal seams could experience outbursts. This paper provided a basis for assessing coal seam outbursts and classifying outburst mine types and listed application examples of solid–gas–stress theory.
The dependence of particle size on cell toxicity for modern mining dust
Authors: Chen Yi-Hsuan , Nguyen Dorothy , Brindley Stephen , Ma Tiancong , Xia Tian , Brune Jürgen , Brown Jared M. , Tsai Candace Su-Jung 
Published: March 2023

AbstractProgressive massive pulmonary fibrosis among coal miners has unexpectedly increased. It would likely due to the greater generation of smaller rock and coal particles produced by powerful equipment used in modern mines. There is limited understanding of the relationship between micro- or nanoparticles with pulmonary toxicity. This study aims to determine whether the size and chemical characteristics of typical coal-mining dust contribute to cellular toxicity. Size range, surface features, morphology, and elemental composition of coal and rock dust from modern mines were characterized. Human macrophages and bronchial tracheal epithelial cells were exposed to mining dust of three sub- micrometer and micrometer size ranges at varying concentrations, then assessed for cell viability and inflammatory cytokine expression. Coal had smaller hydrodynamic size (180–3000 nm) compared to rock (495–2160 nm) in their separated size fractions, more hydrophobicity, less surface charge, and consisted of more known toxic trace elements (Si, Pt, Fe, Al, Co). Larger particle size had a negative association with in-vitro toxicity in macrophages (p < 0.05). Fine particle fraction, approximately 200 nm for coal and 500 nm for rock particles, explicitly induced stronger inflammatory reactions than their coarser counterparts. Future work will study additional toxicity endpoints to further elucidate the molecular mechanism causing pulmonary toxicity and determine a dose–response curve.
Simultaneous multimodal fNIRS-EEG recordings reveal new insights in neural activity during motor execution, observation, and imagery
Authors: Su Wan-Chun , Dashtestani Hadis , Miguel Helga O. , Condy Emma , Buckley Aaron , Park Soongho , Perreault John B. , Nguyen Thien , Zeytinoglu Selin , Millerhagen John , Fox Nathan , Gandjbakhche Amir 
Published: March 2023

AbstractMotor execution, observation, and imagery are important skills used in motor learning and rehabilitation. The neural mechanisms underlying these cognitive-motor processes are still poorly understood. We used a simultaneous recording of functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) to elucidate the differences in neural activity across three conditions requiring these processes. Additionally, we used a new method called structured sparse multiset Canonical Correlation Analysis (ssmCCA) to fuse the fNIRS and EEG data and determine the brain regions of neural activity consistently detected by both modalities. Unimodal analyses revealed differentiated activation between conditions; however, the activated regions did not fully overlap across the two modalities (fNIRS: left angular gyrus, right supramarginal gyrus, as well as right superior and inferior parietal lobes; EEG: bilateral central, right frontal, and parietal). These discrepancies might be because fNIRS and EEG detect different signals. Using fused fNIRS-EEG data, we consistently found activation over the left inferior parietal lobe, superior marginal gyrus, and post-central gyrus during all three conditions, suggesting that our multimodal approach identifies a shared neural region associated with the Action Observation Network (AON). This study highlights the strengths of using the multimodal fNIRS-EEG fusion technique for studying AON. Neural researchers should consider using the multimodal approach to validate their findings.
Study of the distribution of Glycyrrhiza uralensis production areas as well as the factors affecting yield and quality
Authors: Cui Xinping , Lou Lin , Zhang Yan , Yan Binbin 
Published: March 2023

AbstractWild licorice in China is mainly distributed in northern China, such as Gansu, Ningxia, and Inner Mongolia Provinces. The origin of wild licorice has varied among historical periods. The cultivated origin of planted licorice has the same as 59.26% of wild licorice. The distribution of cultivated licorice was shifted to the northwest relative to that of wild licorice. The yield and quality of cultivated licorice vary greatly from different origins, showing a certain pattern of variation from west to east. The same batch of licorice seedlings was planted at 8 sites overlapping the main licorice production areas in China. The yield and quality of licorice in the Baicheng experimental plot were low. The yield of licorice in the Jingtai and Altay experimental plots was high, but the quality was poor. The quality of licorice in Chifeng and Yuzhong experimental sites was high, but the yield was low. Principal component analysis of environmental and soil factors generated five characteristic roots with a cumulative contribution rate of 80%, three of which were related to soil and referred to as the soil charge factor, soil water factor, and soil nutrient factor, and the load coefficients of the water and nutrient factor were the largest. Soil conditions, especially water and nutrients, might have a substantial effect on the observed changes in the licorice production area. Generally, the regulation of water and nutrients merits special attention when selecting areas for the production and cultivation of licorice. This study can provide reference for the selection of cultivated licorice production areas and the research of high-quality cultivation techniques.
2.5D printing of a yield-stress fluid
Authors: Colanges Simon , Tourvieille Jean-Noël , Lidon Pierre , Leng Jacques 
Published: March 2023

AbstractWe report on direct ink writing of a model yield-stress fluid and focus on the printability of the first layer, the one in contact with the supporting substrate. We observe a diversity of deposition morphologies that depends on a limited set of operational parameters, mainly ink flow rate, substrate speed and writing density, and also on material properties (e.g., yield-stress). Among these morphologies, one of them does not depend on fluid properties (as long as the fluid displays some yield-stress) and consists of flat films whose thickness is controllable in a significant range, about $$0.1{-}1$$

0.1
-
1

mm, and tunable in real time during printing. We thus demonstrate the ability to print films with thickness gradients and prove that the printing fidelity is mainly due to a competition between yield-stress and capillarity.
A high-sensitivity rotatable 3D displacement sensor
Authors: Cai Jianxian , Jiang Tao , Gao Zhitao , Shi Yan 
Published: March 2023

AbstractAiming at the problems of low sensitivity and low accuracy caused by the displacement transfer mechanism of three displacement sensors used simultaneously in the 3D displacement monitoring of seismic isolation bearings, the paper has proposed a high-sensitivity rotatable 3D displacement sensor. The sensor adds through holes on the surface of the equal-strength cantilever beam to form a cross beam, which increases the bending strain on the beam surface to improve the sensitivity. By adding a gyroscope and a mechanical rotation structure, a single sensor can measure the 3D displacement at the same time, reducing the adverse effects displacement transmission mechanism on the accuracy of the measurement. ANSYS software was used to simulate and optimize the parameters of the size of through-hole of the sensor beam to determine the appropriate size and location of the through-hole. Finally, the sensor was developed and its static characteristics and displacement measurement performance in static and dynamic 3D space were tested based on the simulation results. The test results have shown that the sensor has a sensitivity of 16.29 mV/mm and an accuracy of 0.9% in the range of 0–160 mm. Its static and dynamic 3D spatial displacement measurement errors are less than 2 mm, which can meet the accuracy requirements of 3D displacement measurement and sensitivity for structural health monitoring of seismic isolation bearings.
Association between lipid levels and all-cause and cause-specific mortality in critically ill patients
Authors: Li Shan , Zhang Wei , Liu Hongbin 
Published: March 2023

AbstractExtremely low lipid levels are considered a sign of debilitation and illness. The association between lipid levels and the risk of mortality in critically ill patients has not been well investigated. This study was designed to evaluate the association between lipid levels and all-cause and cause-specific mortality in critically ill patients using a large collaborative research database known as the eICU database. In total, 27,316 individuals with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) and triglyceride (TG) measurements were analyzed. A J-shaped association was observed between LDL-C, HDL-C, and TC levels and all-cause and noncardiovascular mortality, with low concentrations associated with higher risk. LDL-C, HDL-C and TC levels in the first quintile were associated with higher all-cause and noncardiovascular mortality but not with cardiovascular mortality compared to the reference quintile. There was a marked synergistic effect between low LDL-C combined with low HDL-C on the risk of mortality. Individuals with LDL-C ≤ 96 mg/dL and HDL-C ≤ 27 mg/dL had an increased risk of all-cause mortality (OR 1.52, 95% CI: 1.26–1.82), cardiovascular mortality (OR 1.07, 95% CI: 1.37–1.76) and noncardiovascular mortality (OR 1.82, 95% CI: 1.37–2.43). The results of this observational cohort showed that low LDL-C, HDL-C and TC levels were independently associated with higher all-cause and noncardiovascular mortality in critically ill patients.
Association between familial aggregation of chronic kidney disease and its incidence and progression
Authors: Kim Jae Young , Chun Sung-youn , Lim Hyunsun , Chang Tae Ik 
Published: March 2023

AbstractThis study aimed to examine the association between familial aggregation of chronic kidney disease (CKD) and risk of CKD development and its progression. This nationwide family study comprised 881,453 cases with newly diagnosed CKD between 2004 and 2017 and 881,453 controls without CKD matched by age and sex, using data from the Korean National Health Insurance Service with linkage to the family tree database. The risks of CKD development and disease progression, defined as an incident end-stage renal disease (ESRD), were evaluated. The presence of any affected family member with CKD was associated with a significantly higher risk of CKD with adjusted ORs (95% CI) of 1.42 (1.38–1.45), 1.50 (1.46–1.55), 1.70 (1.64–1.77), and 1.30 (1.27–1.33) for individuals with affected parents, offspring, siblings, and spouses, respectively. In Cox models conducted on patients with predialysis CKD, risk of incident ESRD was significantly higher in those with affected family members with ESRD. The corresponding HRs (95% CI) were 1.10 (1.05–1.15), 1.38 (1.32–1.46), 1.57 (1.49–1.65), and 1.14 (1.08–1.19) for individuals listed above, respectively. Familial aggregation of CKD was strongly associated with a higher risk of CKD development and disease progression to ESRD.