bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of portable sleep monitoring device in diagnosing central sleep apnea in patients with congestive heart failure
Authors: Tung Pi-Hung , Hsieh Meng-Jer , Chuang Li-Pang , Lin Shih-Wei , Hung Kuo-Chun , Lu Cheng-Hui , Lee Wen-Chen , Hu Han-Chung , Wen Ming-Shien , Chen Ning-Hung 
Published: December 2022

IntroductionCentral sleep apnea (CSA) is a common and serious comorbidity mainly occurring in patients with heart failure (HF), which tends to be underdiagnosed and has not been widely studied. Overnight polysomnography (PSG) is the gold standard for diagnosing CSA; however, the time and expense of the procedure limit its applicability. Portable monitoring (PM) devices are convenient and easy to use; however, they have not been widely studied as to their effectiveness in detecting CSA in patients with HF. In the current study, we examined the diagnostic value of PM as a screening tool to identify instances of CSA among patients with HF.MethodsA total of 22 patients under stable heart failure conditions with an ejection fraction of &lt;50% were enrolled. All patients underwent PM and overnight PSG within a narrow time frame. The measurements of the apnea–hypopnea index (AHI), hypopnea index (HI), central apnea index (CAI), and obstructive apnea index (OAI) obtained from PSG, automatic scoring, and manual scoring of PM were recorded. The results obtained from PSG and those from PM (automatic and manual scoring) were compared to assess the accuracy of PM.ResultsAmong the patients, CSA in 11 patients was found by PSG. The AHI measurements performed using manual scoring of PM showed a significant correlation with those performed using PSG (r = 0.69; P = 0.01). Nonetheless, mean AHI measurements showed statistically significant differences between PSG and automatic scoring of PM (40.0 vs. 23.7 events/hour, respectively; P &lt; 0.001), as well as between automatic and manual scoring of PM (23.7 vs. 29.5 events/hour; P &lt; 0.001). Central sleep apnea was detected by PM; however, the results were easily misread as obstructive apnea, particularly in automatic scoring.ConclusionPM devices could be used to identify instances of central sleep apnea among patients with HF. The results from PM were well-correlated with standard PSG results, and manual scoring was preferable to automated scoring.
Naturally cultured high resistant starch rice improved postprandial glucose levels in patients with type 2 diabetes: A randomized, double-blinded, controlled trial
Authors: Tan Ling-li , Duan Wei-qian , Chen Meng-xue , Mei Ying , Qi Xiao-ya , Zhang Yong 
Published: December 2022

ObjectiveTo assess the effect of a novel naturally cultured rice with high resistant starch (RS) on postprandial glycemia in patients with type 2 diabetes compared to ordinary rice.DesignThis study is a randomized, double-blinded controlled trial.MethodsPatients with type 2 diabetes were recruited, and postprandial glucose levels were measured at 5-time points after the ingestion of one of two types of cooked rice in random order. Paired t-tests were used to compare postprandial blood glucose changes and increment areas under the blood glucose curve between high-RS rice and ordinary rice.ResultsThe increments of the postprandial blood glucose levels for high-RS rice were significantly lower than that for ordinary rice, i.e., 2.80 ± 1.38 mmol/L vs. 3.04 ± 1.50 mmol/L (P = 0.043) and 3.94 ± 2.25 mmol/L vs. 4.25 ± 2.29 mmol/L (P = 0.036) at 30 min and 60 min, respectively. The incremental areas under the blood glucose curve for high-RS rice were also significantly lower than that for ordinary rice, i.e., 42.04 ± 20.65 [mmol/(L·min)] vs. 45.53 ± 22.45 [mmol/(L·min)] (P = 0.043), 143.54 ±69.63 [mmol/(L·min)] vs. 155.15 ± 73.53 [mmol/(L·min)] (P = 0.026), and 354.61 ± 191.96 [mmol/(L·min)] vs. 379.78 ± 195.30 [mmol/(L·min)] (P = 0.042) at 30, 60, and 120 min, respectively. Repeated-measures ANOVA showed that postprandial glucose levels were not affected by the test order.ConclusionThe novel high-RS rice as a staple food when substituting for widely consumed ordinary rice may provide potential health benefits by lowering blood glucose in patients with type 2 diabetes.
Acute malnutrition and its contributing factors among children under-five years in rural kebeles of Shashemene Oromia, Ethiopia
Authors: Shifera Nigusie , Endale Aschalew , Debela Degfachew , Yosef Tewodros 
Published: December 2022

IntroductionGlobally, more than 52 million under-five years old were wasted; One-third of these children live in Africa. Ethiopia is the seventh country among the ten top countries in which acute malnutrition (AM) is concentrated and currently 10% of under-five children are wasted. Even though Ethiopia has implemented a variety of nutritional interventions, acute malnutrition is still prevalent and spreading at an alarming rate. Therefore, this study aimed to assess the prevalence of acute malnutrition and its contributing factors among children under-five years of age.Materials and methodsA community-based cross-sectional study was conducted from July 1 to 30, 2018 among 12 randomly selected kebeles. The sample sizes were proportionally allocated to the selected kebeles. A total of 457 mothers/caretakers of under-five children were interviewed using pre-tested structured questionnaires and anthropometric measurements of the children were taken using standard procedures. EPI data version 4.2 was used for data entry and Statistical Package for the Social Sciences (SPSS) Version 21 was used for statistical analysis. The World Health Organization (WHO) Anthro software was used to convert nutritional data indices. Binary logistic regression was used to determine the association between dependent and independent variables. The level of significance was declared at a P-value &lt; 0.05.ResultsThe prevalence of acute malnutrition is 19.91% (95%CI; 16.24%, 23.57%) among under-five children. Factors contributing to acute malnutrition were mothers with no antenatal care (ANC) visits [adjusted odds ratio (AOR) = 2.26, 95% CI 1.14–4.46], mothers who had no autonomy in decision-making (AOR = 2.42, 95% CI 1.42–4.12), children with diarrheal disease in the last 2 weeks preceding the survey (AOR = 2.07, 95% CI 1.19–3.59), and not feeding colostrum (AOR = 1.99, 95% CI 1.07–3.71).Conclusion and recommendationThe prevalence of acute malnutrition is high as compared to other findings in Ethiopia. Moreover, decision-making power, not feeding colostrum, no ANC visit, and a child's history of diarrhea were independent determinants of acute malnutrition. Therefore, the local health department and health extension workers should consider imparting health education for women on nutritional counseling and timely treatment for children with diarrhea. Empowering women's decision-making is also a key element in addressing wasting among under-five children.
Novel MRI deformation-heterogeneity radiomic features are associated with molecular subgroups and overall survival in pediatric medulloblastoma: Preliminary findings from a multi-institutional study
Authors: Iyer Sukanya , Ismail Marwa , Tamrazi Benita , Salloum Ralph , de Blank Peter , Margol Ashley , Correa Ramon , Chen Jonathan , Bera Kaustav , Statsevych Volodymyr , Ho Mai-Lan , Vaidya Pranjal , Verma Ruchika , Hawes Debra , Judkins Alexander , Fu Pingfu , Madabhushi Anant , Tiwari Pallavi 
Published: December 2022

IntroductionMedulloblastoma (MB) is a malignant, heterogenous brain tumor. Advances in molecular profiling have led to identifying four molecular subgroups of MB (WNT, SHH, Group 3, Group 4), each with distinct clinical behaviors. We hypothesize that (1) aggressive MB tumors, growing heterogeneously, induce pronounced local structural deformations in the surrounding parenchyma, and (b) these local deformations as captured on Gadolinium (Gd)-enhanced-T1w MRI are independently associated with molecular subgroups, as well as overall survival in MB patients.MethodsIn this work, a total of 88 MB studies from 2 institutions were analyzed. Following tumor delineation, Gd-T1w scan for every patient was registered to a normal age-specific T1w-MRI template via deformable registration. Following patient-atlas registration, local structural deformations in the brain parenchyma were obtained for every patient by computing statistics from deformation magnitudes obtained from every 5mm annular region, 0 &lt; d &lt; 60 mm, where d is the distance from the tumor infiltrating edge.ResultsMulti-class comparison via ANOVA yielded significant differences between deformation magnitudes obtained for Group 3, Group 4, and SHH molecular subgroups, observed up to 60-mm outside the tumor edge. Additionally, Kaplan-Meier survival analysis showed that the local deformation statistics, combined with the current clinical risk-stratification approaches (molecular subgroup information and Chang’s classification), could identify significant differences between high-risk and low-risk survival groups, achieving better performance results than using any of these approaches individually.DiscussionThese preliminary findings suggest there exists significant association of our tumor-induced deformation descriptor with overall survival in MB, and that there could be an added value in using the proposed radiomic descriptor along with the current risk classification approaches, towards more reliable risk assessment in pediatric MB.
A KCNB1 gain of function variant causes developmental delay and speech apraxia but not seizures
Authors: Veale Emma L. , Golluscio Alessia , Grand Katheryn , Graham John M. , Mathie Alistair 
Published: December 2022

Objective: Numerous pathogenic variants in KCNB1, which encodes the voltage-gated potassium channel, KV2.1, are linked to developmental and epileptic encephalopathies and associated with loss-of-function, -regulation, and -expression of the channel. Here we describe a novel de novo variant (P17T) occurring in the KV2.1 channel that is associated with a gain-of-function (GoF), with altered steady-state inactivation and reduced sensitivity to the selective toxin, guanxitoxin-1E and is clinically associated with neurodevelopmental disorders, without seizures.Methods: The autosomal dominant variant was identified using whole exome sequencing (WES). The functional effects of the KCNB1 variant on the encoded KV2.1 channel were investigated using whole-cell patch-clamp recordings.Results: We identified a de novo missense variant in the coding region of the KCNB1 gene, c.49C&gt;A which encodes a p.P17T mutation in the N-terminus of the voltage-gated, KV2.1 potassium channel. Electrophysiological studies measuring the impact of the variant on the functional properties of the channel, identified a gain of current, rightward shifts in the steady-state inactivation curve and reduced sensitivity to the blocker, guanxitoxin-1E.Interpretation: The clinical evaluation of this KCNB1 mutation describes a novel variant that is associated with global developmental delays, mild hypotonia and joint laxity, but without seizures. Most of the phenotypic features described are reported for other variants of the KCNB1 gene. However, the absence of early-onset epileptic disorders is a much less common occurrence. This lack of seizure activity may be because other variants reported have resulted in loss-of-function of the encoded KV2.1 potassium channel, whereas this variant causes a gain-of-function.
Neutropenia after the coadministration of clozapine and nirmatrelvir-ritonavir in a patient with SARS-CoV-2 infection: A case report with a literature review
Authors: Liu Chun-I , Goh Kah Kheng , Chen Chun-Hsin 
Published: December 2022

BackgroundSchizophrenia is considered one of the major risk factors for mortality from SARS-CoV-2 infection. Early antiviral treatment is important to decrease the risk of mortality. Currently, Paxlovid (nirmatrelvir-ritonavir) has been widely used in SARS-CoV-2 patients with risk factors. However, drug–drug interactions with anti-psychotics are prominent and complicated.Case presentationWe report a clozapine-treated patient with SARS-CoV-2 infection who developed neutropenia after coadministration with Paxlovid. In this case, clozapine was used for over 15 years, without neutropenia development. However, severe neutropenia (absolute neutrophil count = 523/μl) developed 3 days after the coadministration of Paxlovid 2 doses per day, valproic acid 1,000 mg per day and clozapine 100 mg per day. The development of neutropenia may be attributed to the complicated interaction among Paxlovid, SARS-CoV-2 infection, valproic acid, fluvoxamine and clozapine.ConclusionsNeutropenia is a rare but life-threatening event if a concomitant infection occurs. The risk may increase during SARS-CoV-2 infection and the coadministration of clozapine and Paxlovid. Although the exact causes of neutropenia in this patient are not fully clear, the white blood cell count and absolute neutrophil count should be closely monitored during the administration of Paxlovid in clozapine-treated patients with SARS-CoV-2 infection.
Xylityl Sesquicaprylate Efficacy as an Antiseptic Ingredient for Oral Care Products (Mouthwash): An In Vitro Screening Investigation against Eight Microorganisms
Authors: Nogueira Cecília , Mussi Liliam , Baby André Rolim , Zupeli Roseli , Magalhães Wagner Vidal 
Published: December 2022

For dental caries and periodontal diseases initiated by dental plaque (as bacterial communities) and to inhibit the growth of oral pathogenic bacteria, oral care products containing antiseptic active ingredients are highly recommended, nonetheless, side effects of such actives are a concern (teeth discoloration/staining and taste perception, for example). In this context, we challenged xylityl sesquicaprylate, an antiseptic compound from natural resources, as an active ingredient to be used in an alcohol-free mouthwash formulation. The xylityl sesquicaprylate sample was compared to a respective blank mouthwash formulation and one containing triclosan. The in vitro efficacy was screened by the time-kill assay against eight microorganisms. The xylityl sesquicaprylate-containing mouthwash (0.45% w/w) presented a particularly interesting profile of efficacy against Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, with results of greater magnitude to reduce the log10 of those microorganisms in comparison with the triclosan sample.
Entrevista com Rita Meoño Molina
Authors: Molina Rita Andrea Meoño , Moljo Carina Berta 
Published: December 2022

Entrevista con Rita Meoño Molina, Presidente de la ALAEITS Gestión 2020- 2023 para la Revista Libertas de la Universidad Federal de Juiz de Fora: Facultad de Trabajo Social /Programa de Pós-graduación en Trabajo Social.
Entrevistadora: Carina Berta Moljo, professora titular da Facultad de Trabajo Social, Investigadora del CNPq
Concepciones de una comunidad de práctica intercultural. El caso del profesor Benjamín en una institución de educación del distrito capital (Bogotá-Colombia)
Authors: Osorio Claudia Patricia Orjuela , Andrade Adela Molina , Suárez Oscar Jardey 
Published: December 2022

Se presentan algunos resultados de la investigación doctoral[1] que se pregunta por las comunidades de práctica en enseñanza de las ciencias con una perspectiva de la diversidad cultural denominadas CoP-I. Se describe el proceso metodológico y de análisis en la fase cualitativa de la tesis, para la interpretación de las concepciones individuales de un profesor vinculada a la secretaria de Educación del Distrito Capital (Bogotá-Colombia), a partir de la entrevista basada en situaciones. Como resultado se establece un modelo de concepción para entender la práctica profesional como a) un proceso de construcción de una cultura propia en el ámbito escolar y b) la acción del profesor se construye y se reconstruyen a partir relaciones estructurales entre conocimientos, valores y creencias y prácticas sociales acorde con el origen cultural individual del profesor.
Los nuevos modelos de negocios y la aplicación del principio de prevencion de operaciones ilicitas desafios y responsabilidades
Authors: Soria Graciela Cristina Cami 
Published: December 2022

La Cuarta Revolución Industrial junto con el descrédito de la banca tradicional, producto de las últimas grandes crisis, y otros fenómenos que se desarrollarán en el presente trabajo, ha venido afectando el sector financiero y propiciado el auge de nuevos emprendimientos y plataformas web vinculados a las finanzas. Se ingresa de esta forma al mundo de los crowlending, los peer to peer lending y las FinTech. Las tecnologías que emplean y la modalidad en cómo operan algunos de estos nuevos modelos de negocios, los hace susceptibles de convertirse en instrumentos para el lavado de activos y financiamiento al terrorismo. El presente trabajo tiene por cometido analizar las circunstancias que han facilitado la aparición de esos nuevos modelos de negocios en línea, vinculados al sector financiero. Muchos países de la región vienen monitoreando de cerca este fenómeno, pero muy pocos cuenta con normativa que regule estos emprendimientos. En este trabajo se investiga el accionar de algunos ordenamientos jurídicos con el fin de supervisar las actividades desarrolladas por esas nuevas empresas. En principio se ha explorado el derecho comparado, en particular la ley mexicana que regula las Instituciones de Tecnología Financiera, para luego abordar el estudio de la normativa uruguaya. Es así que se incluye una novedosa Circular dictada recientemente por el Banco Central del Uruguay que reglamenta la actividad de las empresas administradoras de plataformas web de préstamos entre personas. Se incorpora asimismo una sucinta referencia a soluciones alternativas, como lo son las Sandbox. A lo largo de esta investigación se ha visto que el verdadero desafío para estas iniciativas y sus reguladores, radica en controlar estos negocios sin correr el riesgo de hacerlos desaparecer. No obstante, se concluye que hay un interés superior, el cual consiste en dar cumplimiento al principio de prevención de operaciones ilícitas, para lo cual deben aplicarse los estándares internacionales en materia de lavado de activos, en especial la Recomendaciones de GAFI sobre nuevas tecnologías, con el fin de mitigar riesgos y evitar que estas plataformas tecnológicas sean empleadas como instrumentos para cometer ilícitos (lavar activos o financiar el terrorismo).
Análise das indicações de partos cesáreos segundo a classificação dos dez grupos de Robson em maternidade de baixo risco de Sorocaba-SP
Authors: Novo Joe Luiz Vieira Garcia , Izzo Felipe Passos Martins , Hamamoto Leonardo Galli 
Published: December 2022

Objetivos: a pesquisa realizou estudo descritivo, prospectivo, analisando a distribuição das indicações dos partos cesáreos no HSL, segundo o sistema da Classificação de Robson. Métodos: coletados dados de prontuários médicos (gestantes e parturientes de termo e pré-termo) cesariadas, resolução da gestação durante o período de estudo. Resultados: a proporção total de partos cesáreas foi 33,67%, abaixo da média do Brasil (55,6%), superando os níveis preconizados pela OMS (15%), e mundial (21,1%). Cerca de 15,30% dos partos cesáreos realizaram-se em pacientes com trabalho de parto espontâneo, feto único, de termo, cefálico, em nulíparas e multíparas sem cesáreas prévias: grupos 1 (11,20%) e 3 (4,10%). Viram-se nulíparas (grupo 2) e multíparas (grupo 4): feto único, de termo, cefálico, sem cesáreas prévias, com trabalho de parto induzido ou realizada cesárea antes do início do parto: 21,86% e 4, 92% respectivamente. Houve maior número de multíparas com cesárea (s) prévia (s), gestação de termo, feto único, cefálico (grupo 5): 41,80%. Operaram-se: feto único, pélvico, de termo, nulíparas (grupo 6: 3,01%) e multíparas (grupo 7: 5,46%); córmico ou oblíquo (grupo 9: 1,09%) e pré-termo (grupo 10: 6,56%). Conclusão: os grupos da classificação de Robson constituíram ferramenta de grande utilidade, analisando de forma individualizada, conjunta, as proporções de partos cesáreas nesta instituição. Sugerem-se que para ocorrerem menores proporções de intervenções cirúrgicas, que nos grupos 1 e 3 utilizem analgesias intrapartos e alívios nos períodos expulsivos; os grupos 2 e 4 requerem seletividade em induções aos partos, além de indicações precisas de cesáreas em gravidez de termo.
Diagnóstico do gerenciamento dos resíduos de serviços de saúde da Unidade de Pronto Atendimento - UPA, Tucuruí - Pará
Authors: Pereira Aline Carolina , Santos Rangel Cavalcante , Sousa Etiene Elayne Meireles da Rocha , Silva Elyene Elene Meireles da Rocha , Castillo Andreza de Souza 
Published: December 2022

A destinação dos Resíduos Sólidos de Serviços de Saúde (RSS) sem conformidade com a legislação ocasiona danos ao meio ambiente e à saúde humana. Diante disso, este estudo buscou analisar o gerenciamento dos RSS, da Unidade de Pronto Atendimento – UPA, localizada no bairro Santa Mônica, município de Tucuruí-Pará. Verificando concordância com os procedimentos implementados no local para com as exigências da Resolução da Diretoria Colegiada (RDC), Nº 222, de 28 de março de 2018. E também, realizou-se uma análise da percepção dos profissionais de saúde da unidade, quanto ao manejo dos RSS e suas adequações, afim de proporcionar compreensão dos seus riscos e propor melhorias diante aos resultados encontrados.
Pengaruh Lingkungan Kerja dan Motivasi Kerja terhadap Kinerja Personil Polresta Padang Dengan Kepuasan Kerja sebagai Pemediasi
Authors: Medriadi Medriadi 
Published: December 2022

Penelitian ini bertujuan untuk mengetahui Pengaruh Lingkungan Kerja dan Motivasi Kerja terhadap Kinerja Personil Polresta Padang dengan Kepuasan Kerja Sebagai Variabel Intervening. Jumlah sampel yang digunakan sebanyak 81 orang. Metode analisis yang digunakan adalah Analisis Structral Equation Modeling (SEM) dengan Partial Least Square (PLS). untuk uji hipotesis digunakan yaitu Path Coeficient yaitu pengujian yang dilakukan untuk melihat pengaruh langsung dan Indirect Effect merupakan pengujian yang bertjuan untuk melihat pengaruh tidak langsung. Hasil penelitian ini menunjukkan bahwa: 1). Lingkungan kerja berpengaruh positif dan siginifikan terhadap Kepuasan kerja pada personil Polresta Padang. 2) Motivasi berpengaruh positif dan signifikan terhadap Kepuasan kerja pada personil Polresta Padang. 3) Lingkungan kerja berpengaruh positif dan tidak siginifikan terhadap Kinerja Personil pada personil Polresta Padang. 4) Motivasi berpengaruh positif dan tidak signifikan terhadap Kinerja Personil pada personil Polresta Padang. 5) Kepuasan kerja berpengaruh positif dan siginifikan terhadap Kinerja Personil pada personil Polresta Padang. 6) Kepuasan kerja memediasi lingkungan kerja terhadap kinerja personil Polresta Padang. 7) Kepuasan kerja memediasi motivasi terhadap kinerja personil Polresta Padang.
Virtud cristiana y progreso liberal en La Navidad en las Montañas de Ignacio M. Altamirano
Authors: Santillán Gustavo 
Published: December 2022

El artículo explora la tensión entre la separación Estado e iglesia, y la colaboración entre ministros religiosos y figuras civiles en la novela La Navidad en las montañas (1871) de Ignacio Manuel Altamirano. A partir de este elemento y de la historiografía revisionista, analiza la interpretación predominante de la historiografía tradicional en torno tanto de la libertad de culto como de la independencia entre la iglesia católica y la autoridad política durante la república restaurada. Asimismo, identifica el tipo de ética, secular o religiosa, presente en la novela dentro de un contexto muy favorable a una visión laica de la virtud. En su conjunto, el texto aborda la temática moral, muy presente en discursos y relatos decimonónicos, pero relativamente ausente de la investigación mexicana, a partir de una visión contextual.