bluuebunny/crossref_metadata_2025_split huggingface dataset:
Designing electrostatic synergistic nanohybrid interface layer in polyester fiber for asphalt binder modification
Authors: He Lu , Fan Shencheng , Muhammad Yaseen , Cheng Yao , Zhao Zhenxia , Li Jing 
Published: June 2023

AbstractIn this study, a novel multiscale synergistic reinforced polyester fiber (PET) was prepared by a bionic coating and electrostatic synergism. The three‐dimensional (3D) interconnected structure was developed on the surface of PET by electrostatically synergistic hybridization of negatively charged 2D lamellar graphene oxide (GO) and positively charged 1D hollow tubular aminated halloysite nanotubes (HNT). These fibers were applied to prepare fiber incorporated styrene‐butadiene‐styrene modified asphalt (SBS@MA). X‐ray photoelectron spectroscopy, atomic force microscopy, and field emission scanning electron microscopy analyses revealed that the 3D interconnected highly rough structure was constructed on the fiber surface. The surface free energy and adhesion work at the fiber and asphalt were calculated from the contact angle tests, which showed that adhesion work of the modified fibers was improved by 30% compared with the original fibers, confirming the better adhesion performance of GO‐mHNT‐PET fibers with the asphalt. The improved mechanical and viscoelastic characteristics of the modified GO‐mHNT‐PET/SBS@MA were verified by dynamic shear rheometer, and multistress creep recovery tests. At 46°C, the complex modulus of 1.5% GO‐mHNT‐PET/SBS@MA was 31.02% higher compared with that of PET/SBS@MA. This study provides a promising strategy for the preparation of PET/SBS@MA materials with excellent mechanical properties and interfacial bonding.
Ala307Thr variation modulates FSHR structure and impairs its binding affinity for FSH: Implications in polycystic ovarian syndrome
Authors: Amin Asif , Lone Asif , Wani Umer Majeed , Farooq Faizah , Shah Ruchi , Kumar Rakesh , Qadri Raies A. 
Published: June 2023

AbstractFollicle‐stimulating hormone receptor (FSHR) belongs to the family of G‐protein coupled receptors and acts as a cognate receptor for follicle‐stimulating hormone (FSH). Among the various polymorphic changes reported in FSHR, rs6165 polymorphism leading to Ala307Thr variation in the extracellular domain of the FSHR (FSHRED) is widely reported. Therefore we attempted to evaluate the functional implications of this variation by studying its effects on FSHRED structure as well as FSH binding. Our atomic‐scale investigations reveal that the hinge region, a key hormone interaction site in the extracellular domain of Wt FSHR, exhibits significantly more flexibility compared with the variant structure. Moreover, the Wt receptor in complex with FSH was observed to form a pocket‐like structure in its hinge region whereas such a structure was not detected in the variant. The study further reveals that the key residue, sTyr335, required for FSH recognition and FSHR activation, exhibits lower binding free energy in the variant structure as compared to the Wt. In conclusion, our results point out that Ala307Thr variation leads to structural and conformational anomalies in FSHRED which may alter its FSH binding and affect its activation.
A Brief Guide to Preparing a Peptide–Drug Conjugate
Authors: Bugatti Kelly 
Published: June 2023

AbstractPeptide–drug conjugates (PDCs) have recently emerged as interesting hybrid constructs not only for targeted therapy, but also for the early diagnosis of different pathologies. In most cases, the crucial step in the PDC synthesis is the final conjugation step, where a specific drug is bound to a particular peptide‐/peptidomimetic‐targeting unit. Thus, this concept paper aims to give a short guide to determining the finest conjugation reaction, by considering in particular the reaction conditions, the stability of the linker and the major pros and cons of each reaction. Based on the recent PDCs reported in literature, the most common and efficient conjugation methods will be systematically presented and compared, generating a short guide to consult while planning the synthesis of a novel peptide–drug conjugate.
Maximizing blockchain security: Merkle tree hash values generated through advanced vectorized elliptic curve cryptography mechanisms
Authors: Sharma Durgesh M. , Shandilya Shishir Kumar , Satapathy Suresh Chandra 
Published: June 2023

SummaryCloud computing is considered as the most fabulous paradigm to accommodate various kinds of user information. However, the privacy conflicts integrated with computational complexities need more hybridized resource efficiency for hassle‐free accession. For this purpose, this article presents a cloud assisted, secured and privacy preserved protocol based on the elliptical curve cryptography (ECC) and blockchain consortium. Blockchain provides an innovative approach for storing information, establishing trust, and various other transactions in an open platform. There exists no single technology as a panacea to obtain optimum privacy and security in the complex cloud environment that needs several desired characteristics. Hence, an elite integration of multiple cryptographic methods by carefully analyzing the potential harms and pitfalls has to be framed to balance the trade‐off between privacy and security. The proposed technique highlights the user privacy preservation through guaranteeing that user information is safeguarded from unauthorized use or access. In accordance with that the present study enrolled the advantages of the ECC algorithm, vectorization, and blockchain methods to rule out the limitations of state of art methods. This article attempts to provide the most required privacy with optimum key generation, encryption, and decryption time. The present study has obtained optimal outcomes and the maximum percentage reduction w.r.t the existing method in key generation time, encryption time, and decryption time is given as 14.89%, 16.67%, and 12.5%, respectively.
Representativeness of samples enrolled in Alzheimer's disease research centers
Authors: Arce Rentería Miguel , Mobley Taylor M. , Evangelista Nicole D. , Medina Luis D. , Deters Kacie D. , Fox‐Fuller Joshua T. , Minto Lex R. , Avila‐Rieger Justina , Bettcher Brianne M. 
Published: June 2023

AbstractTo generalize findings on the mechanisms and prognosis in Alzheimer's disease and related dementias (ADRD), it is critical for ADRD research to be representative of the population. Sociodemographic and health characteristics across ethnoracial groups included in the National Alzheimer's Coordinating Center sample (NACC) were compared to the nationally representative Health and Retirement Study (HRS).Baseline NACC data (n = 36,639) and the weighted 2010 HRS wave (N = 52,071,840) were included. We assessed covariate balance by calculating standardized mean differences across harmonized covariates (i.e., sociodemographic, health).NACC participants were older, more educated, with worse subjective memory and hearing, but endorsed fewer depressive symptoms compared to HRS participants. While all racial and ethnic groups in NACC differed from HRS participants in the same way overall, these differences were further amplified between racial and ethnic groups.NACC participants do not represent the U.S. population in key demographic and health factors, which differed by race and ethnicity.HIGHLIGHTS
We examined selection factors included in NACC studies compared to a nationally representative sample.
Selection factors included demographic and health factors and self‐reported memory concerns.
Results suggest that NACC participants are not representative of the U.S. population.
Importantly, selection factors differed across racial and ethnic groups.
Findings are suggestive of selection bias within NACC studies.
Challenges of copro‐parasitological surveys in wild Iberian ibex (Capra pyrenaica) populations addressed through a combination of molecular and statistical tools
Authors: Fontoura‐Gonçalves Catarina , Portocarrero Érica , Oliveira Ana , Lozano João , Rinaldi Laura , Cringoli Giuseppe , Madeira de Carvalho Luís , Santos Nuno 
Published: June 2023

AbstractCopro‐parasitological surveys in wildlife face challenges due to the secretive nature of many species and the unknown performance of the diagnostic tests employed. To overcome these issues, we used a combination of hierarchical models (site‐occupancy and N‐mixture models) applied to copro‐parasitological data obtained from fecal samples assigned to the host species by molecular methods in the Iberian ibex in north‐western Iberian Peninsula. The aims were to compare the performance of four diagnostic tests (Mini‐FLOTAC, McMaster, Willis flotation, and natural sedimentation) and to use this methodological approach (molecular analysis with hierarchical models) to better estimate positivity proportion and shedding intensity in a wild ibex population. Pooled fecal samples were collected, and those confirmed by molecular analyses to be the host species in question were included in the study. Hierarchical models confirmed different performances of each diagnostic test, with Mini‐FLOTAC showing higher sensitivity for eimeriid coccidia, Willis flotation (for proportion positive) and McMaster (for shedding intensity) in gastrointestinal Strongylida, and equal performance of MiniFlotac/Willis flotation (for proportion positive) and MiniFlotac/McMaster (for shedding intensity) in Moniezia spp. This study employed a combination of molecular and statistical methods that improved the estimates of prevalence and shedding intensity and allowed us to compare the performance of four diagnostic tests while assessing the effect of covariates. Such improvements are critical to enhancing inference in non‐invasive wildlife copro‐parasitological studies.
Rising arterial stiffness with accumulating comorbidities associates with heart failure with preserved ejection fraction
Authors: Ali Danish , Tran Patrick , Ennis Stuart , Powell Richard , McGuire Scott , McGregor Gordon , Kimani Peter K. , Weickert Martin O. , Miller Michelle A. , Cappuccio Francesco P. , Banerjee Prithwish 
Published: June 2023

AbstractAimsComorbidities play a significant role towards the pathophysiology of heart failure with preserved ejection fraction (HFpEF), characterized by abnormal macrovascular function and altered ventricular–vascular coupling. However, our understanding of the role of comorbidities and arterial stiffness in HFpEF remains incomplete. We hypothesized that HFpEF is preceded by a cumulative rise in arterial stiffness as cardiovascular comorbidities accumulate, beyond that associated with ageing.Methods and resultsArterial stiffness was assessed using pulse wave velocity (PWV) in five groups: Group A, healthy volunteers (n = 21); Group B, patients with hypertension (n = 21); Group C, hypertension and diabetes mellitus (n = 20); Group D, HFpEF (n = 21); and Group E, HF with reduced ejection fraction (HFrEF) (n = 11). All patients were aged 70 and above. Mean PWV increased from Groups A to D (PWV 10.2, 12.2, 13.0, and 13.7 m/s, respectively) as vascular comorbidities accumulated independent of age, renal function, haemoglobin, obesity (body mass index), smoking status, and hypercholesterolaemia. HFpEF exhibited the highest PWV and HFrEF displayed near‐normal levels (13.7 vs. 10 m/s, P = 0.003). PWV was inversely related to peak oxygen consumption (r = −0.304, P = 0.03) and positively correlated with left ventricular filling pressures (E/e′) on echocardiography (r = −0.307, P = 0.014).ConclusionsThis study adds further support to the concept of HFpEF as a disease of the vasculature, underlined by an increasing arterial stiffness that is driven by vascular ageing and accumulating vascular comorbidities, for example, hypertension and diabetes. Reflecting a pulsatile arterial afterload associated with diastolic dysfunction and exercise capacity, PWV may provide a clinically relevant tool to identify at‐risk intermediate phenotypes (e.g. pre‐HFpEF) before overt HFpEF occurs.
Photoinduced Reaction of α‐Bromoacetophenone with Thiosulfonate: Synthesis of β‐Keto Thiosulfone
Authors: Zhu Wei‐Chen , Jiang Yi‐Fan , Liu Xin‐Yu , Tian Shi‐Yin , Rao Weidong , Shen Shu‐Su , Song Ping , Sheng Daopeng , Wang Shun‐Yi 
Published: June 2023

AbstractA photoinduced synthesis of β‐keto thiosulfone/β‐keto selenosulfone by the reaction of α‐bromoacetophenone with thiosulfonate/selenosulfonate under metal‐free and visible light irradiation conditions is developed. Two C−S bonds or one C−S bond and one C−Se bond were constructed simultaneously.
Secure Internet of Thing based data communication in blockchain model using novel teaching‐learning optimized fuzzy approach
Authors: Josphineleela R. , Pellakuri Vidyullatha , Thanuja R. , Moses Diana 
Published: June 2023

AbstractThe potential uses in the Internet of Things (IoT), blockchain is gaining prominence. It is particularly skillful at storing data in immutable blocks, which is connected to its protected peer‐to‐peer architecture in the face of a growing challenge of transaction authorization in industrial and service‐provider applications. IoT is prolonged to several additional applications as a result of its integration with various technologies, allowing direct engagement with our individual and professional lives. The major aim of this study is to provide the security based IoT data communication in blockchain using novel techniques. The device's security is a significant concern. However, on‐demand security solutions have issues since devices have limited processing and energy resources. IoT devices do not allow for the use of large, costly systems. In order to address these issues, we present a novel optimized fuzzy architecture for a blockchain‐based IoT device data exchange and communication in this research. The TLBO method is used to improve decision‐making capabilities, while the Mamdani fuzzy inference system makes the majority of the decisions. To construct the two input variables (drop ratio and integrated trust level) and reduce the dimensionality of the input information, the TLBO method was used. We examine and illustrate the efficacy of our method with another state‐of‐art method. Based on the experiment, we have obtained 1.8, 2.1, 2.8, 3.2 and 3.8 ms computational time based on the number of users from 2 to 10, respectively. The proposed method attains 96% accuracy and 95.4% F‐score results than other previous methods.
The effect of celery (Apium graveolens) powder on cardiometabolic factors in overweight/obese individuals with type 2 diabetes mellitus: A pilot randomized, double‐blinded, placebo‐controlled clinical trial
Authors: Mohsenpour Mohammad Ali , Samadani Mahsa , Shahsavani Zeinab , Golmakani Mohammad Taghi , Pishdad Gholam Reza , Ekramzadeh Maryam 
Published: June 2023

AbstractCelery (Apium graveolens) was shown to have beneficial effects on cardiometabolic factors in animal models. As the progression of type 2 diabetes mellitus (T2DM) adversely affects cardiometabolic factors, we aimed to assess the effects of celery powder on glycemic and anthropometric indices, lipid profile, liver function, oxidative stress, and blood pressure of individuals with T2DM. In a pilot randomized, double‐blinded, placebo‐controlled clinical trial, 50 eligible adults with T2DM were randomly divided into two groups of intervention and control to consume either 750 mg of celery powder (obtained from fresh celery) or placebo along with a low‐calorie diet for 12 weeks, respectively. Dietary intake, physical activity, and cardiometabolic factors were assessed before and at the end of the study. Thirty‐six patients finished the study (18 in each group). Consumption of celery powder significantly reduced body fat percentage (p = .021). Between‐group analysis for changes in cardiometabolic factors did not show significant differences. Although malondialdehyde was reduced in the intervention group and increased in the control group, between‐group changes were not significant. Although the insulin‐level change was statistically insignificant, a clinical improvement was observed in the intervention group. A 750‐mg daily supplementation of celery powder for 12 weeks did not improve the cardiometabolic factors of patients with T2DM. Further studies are suggested.
Non‐invasive brain stimulation for treating post‐stroke depression: A network meta‐analysis
Authors: Yanyu Sun , Ying Li , Kexin Li , Jin Wu 
Published: June 2023

AbstractObjectiveTo compare the antidepressant effects and tolerability of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) treatments in patients with post‐stroke depression (PSD).MethodsWe included randomized controlled trials comparing active stimulation with sham stimulation. Primary outcomes were the depression score after treatment, presented as standardized mean differences with 95% confidence intervals. Response/remission and long‐term antidepressant efficacy were also examined. We estimated effect‐size using pairwise and Bayesian network meta‐analysis (NMA) with random‐effects model.ResultsWe identified 33 studies (total n = 1793). In NMA, 5 of 6 treatment strategies were associated with higher effect compared with sham therapy: dual rTMS (standardized mean differences = −1.5; 95% confidence interval = −2.5 to −0.57), dual LFrTMS (−1.5, −2.4 to −0.61), dual tDCS (−1.1, −1.5 to −0.62), HFrTMS (−1.1, −1.3 to −0.85) and LFrTMS (−0.90, −1.2 to −0.6). And dual rTMS, dual LFrTMS or HFrTMS may be more effective than other interventions for achieving antidepressant effects. Regarding secondary outcomes, rTMS can promote depression remission and response, and alleviate depression for at least 1 month. rTMS and tDCS were well tolerated.ConclusionsBilateral rTMS and HFrTMS are considered top‐priority non‐invasive brain stimulation (NIBS) interventions for improving PSD. Dual tDCS and LFrTMS are also efficient.SignificanceThe findings of this study provide evidence for considering NIBS techniques as alternative or add‐on treatments for patients with PSD. This work also emphasizes the need for future clinical trials to address the inadequacies identified in this review to optimize methodological quality.
Mega dam‐induced riverbed erosion exacerbates drought effects on river water surface elevation
Authors: Mei Xuefei , Dai Zhijun , Du Jinzhou , Darby Stephen E. 
Published: June 2023

AbstractBy regulating the seasonal flow discharge, dams are frequently used to augment downstream flow discharges and water surface elevations in dry season periods. However, dams also typically generate severe bed incision in their downstream reaches, which whilst not reducing the volume of flow passing through the channel, can nevertheless reduce water surface elevations. Such reductions in water surface elevations can make it more difficult to access available water in the river in instances where they drop substantially below the levels of water intake structures. Here, we evaluate the extent to which dam‐induced incision downstream of the Three Gorges Dam (TGD) contributes to falling water surface elevations during the 2019 dry season (December to February), which was a period characterized by extremely low water surface elevations along the mid‐lower reaches of the Changjiang River. Our results indicate that the 2019 dry season exhibited the second lowest water surface elevation ever recorded in the middle Changjiang even though the flow discharge was actually larger than in previous dry seasons. The 2019 event was found to be characterized by a sharp fall of water surface elevation, caused by TGD‐induced downstream channel narrowing and bed incision. Thus, whilst TGD releases did augment flows during the 2019 dry season, channel degradation resulted in a substantial net lowering of water surface elevations. Consequently, the overall impact of the TGD on dry season water surface elevations was to aggravate (not mitigate) low water surface elevations experienced along the Changjiang River. Our study has relevance for other major dam‐altered rivers that experience extreme low water surface elevations in dry periods.
Experimental density and volumetric properties of DESs based on tetrabutylammonium bromide and used for effective extraction of naphthol green B and malachite green
Authors: Thamby Beevi Fathima Mohamed , Santhi Vivek Mariappan , Ramalingam Anantharaj 
Published: June 2023

AbstractBACKGROUNDTo improve the quality of wastewater and thereby to meet the standards as per environmental production agency in US and UK. In the present work, Malachite green (MG) and Naphthol Green B (NGB) has been taken as model dyes in wastewater. Solvent extraction process was carried out using deep eutectic solvents (DESs) as an alternative solvent for organic and ionic liquids.RESULTSThe possible molecular interaction between DESs and selective dyes in water were analyzed and discussed in details using volumetric properties including excess molar volume , partial molar volume , excess partial molar volume , apparent molar volume , isobaric thermal expansion () and excess isobaric thermal expansion (αE). Further, the extraction of selective dyes was conducted and characterized in terms of extraction efficiency (η), effect of temperature on extraction efficiency, effect of shaking time on extraction efficiency, effect of concentration on extraction efficiency, effect of HBD on extraction efficiency, distribution coefficient (D). Finally, the thermodynamic extraction feasibility was analysed by means of Gibbs free energy , change in enthalpy , and change in entropy .CONCLUSIONThere is possible molecular interaction between hydrophilic DESs and NGB/MG in water at molecular level. 96% of extraction efficiency was obtained for NGB using hydrophobic DESs like {[TBAB][DA]} and {[TBAB][OA]} whereas {[TBAB][DA]} and {[TBAB][OA]} gave above 72% removal efficiency of MG. Finally the thermodynamic feasibility of extraction process was analyzed and discussed. © 2023 Society of Chemical Industry (SCI).
Zero Echo Time Magnetic Resonance Imaging; Techniques and Clinical Utility in Musculoskeletal System
Authors: Fujisaki Akitaka , Tsukamoto Jun , Narimatsu Hidekuni , Hayashida Yoshiko , Todoroki Yo , Hirano Natsumi , Takeda Kazuki , Shin Sho , Ota Satoru , Anai Kenta , Fukumitsu Satoshi , Yoshimatsu Yuta , Kono Yuichiro , Ueno Midori , Ide Satoru , Murakami Yu , Aoki Takatoshi 
Published: June 2023

Zero echo time (ZTE) sequence is recent advanced magnetic resonance technique that utilizes ultrafast readouts to capture signals from short‐T2 tissues. This sequence enables T2‐ and T2* weighted imaging of tissues with short intrinsic relaxation times by using an extremely short TE, and are increasingly used in the musculoskeletal system. We review the imaging physics of these sequences, practical limitations, and image reconstruction, and then discuss the clinical utilities in various disorders of the musculoskeletal system. ZTE can be readily incorporated into the clinical workflow, and is a promising technique to avoid unnecessary radiation exposure, cost, and time‐consuming by computed tomography in some cases.Level of Evidence4Technical EfficacyStage 1