bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms of microstructural deformation governing Vickers hardness in phase‐separated calcium aluminosilicate glasses
Authors: Clark Nicholas L. , Chuang Shih‐Yi , Mauro John C. 
Published: April 2023

AbstractThe impact of microstructure on hardness in phase‐separated calcium aluminosilicate glasses is investigated. Changes in hardness are governed by microstructure deformations that occur during indentation. Phase separation leads to decreased hardness due to the incongruent yielding of the droplet and matrix phases. Moreover, the deformation of microstructures possessing dilute, spherical droplets did not have a significant impact on hardness. Microstructures characterized by concentrated, acicular droplets were found to deform through a process of droplet coalescence. This process absorbs additional energy during yielding and results in glasses that deform through droplet coalescence possessing improved hardness.
Figure S2: Effect of treatment protocol on migration in PC3 and PC-3(AR)2 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Authors: Miao Lu , Yang Lin , Li Rui , Rodrigues Daniel N. , Crespo Mateus , Hsieh Jer-Tsong , Tilley Wayne D. , de Bono Johann , Selth Luke A. , Raj Ganesh V. 
Published: April 2023

<p>PC3 and PC-3(AR)2 cells were subjected to the treatment protocol (Fig.1A). After 6 days of treatment, the monolayer surface was scratched carefully and washed. Wound healing at 24 hours under normal growth media conditions was quantitated. Data are expressed as percentage of wound healing (WH %) calculated by dividing migrated distance by scratched distance.</p>
Supplementary Table S1 from Preclinical Efficacy of the Auristatin-Based Antibody–Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors
Authors: Sommer Anette , Kopitz Charlotte , Schatz Christoph A. , Nising Carl F. , Mahlert Christoph , Lerchen Hans-Georg , Stelte-Ludwig Beatrix , Hammer Stefanie , Greven Simone , Schuhmacher Joachim , Braun Manuela , Zierz Ruprecht , Wittemer-Rump Sabine , Harrenga Axel , Dittmer Frank , Reetz Frank , Apeler Heiner , Jautelat Rolf , Huynh Hung , Ziegelbauer Karl , Kreft Bertolt 
Published: April 2023

<p>The expression of FGFR2 on tumor cell surface and half maximal inhibitory concentration of cell viability for FGFR2-ADC BAY 1187982 and control ADC.</p>
Supplementary Figure Legends from Accumulation of MDSC and Th17 Cells in Patients with Metastatic Colorectal Cancer Predicts the Efficacy of a FOLFOX–Bevacizumab Drug Treatment Regimen
Authors: Limagne Emeric , Euvrard Romain , Thibaudin Marion , Rébé Cédric , Derangère Valentin , Chevriaux Angélique , Boidot Romain , Végran Frédérique , Bonnefoy Nathalie , Vincent Julie , Bengrine-Lefevre Leila , Ladoire Sylvain , Delmas Dominique , Apetoh Lionel , Ghiringhelli François 
Published: April 2023

<p>Supplementary Figure 1: THelper gating strategy Flow cytometry gating strategy to identify memory CD4 T cell subpopulations through chemokine receptor expression. Supplementary Figure 2: MDSC gating strategy and IL-4Rα expression analysis. A.	Flow cytometry gating strategy to identify MDSC subpopulations through CD33, Lin (=CD3, CD20, CD19 and CD56), HLA-DR, CD14 and CD15 marker expression. Pictures correspond to May-Grünwald Giemsa staining mMDSC and gMDSC isolated after cell sorting. B.	As in A, we identify MDSC subpopulations, granulocytes and monocytes and we have analyzed IL-4Rα (CD124) expression in 3 mCRC patients. Supplementary Figure 3: Blood parameters in Healthy Volunteers versus mCRC patients Whole blood of Healthy volunteers and metastatic colorectal cancer patient (mCRC) was sample on EDTA-K2 tubes (BD Bioscience) and a complete blood count (CBC) was performed in Clinical Biology Unit (Centre George François Leclerc). Supplementary Figure 4: IFN-γ and IL-17A secretion by CCR6 and CXCR3 expressing CD4 T cells PBMCs of mCRC patients were stained after PMA/ionomycin/Brefeldin/Monensin stimulation (4 hrs) with anti-CD4, anti-CD45RA, anti-CCR6, anti-CXCR3, anti-IFN-γ and anti-IL-17A antibodies and analyzed by flow cytometry. The expression of IFN-γ and/or IL-17A on memory CD4 (CD45RA- CD4+) Th1 (CCR6- CXCR3+), Th17 (CCR6+ CXCR3-), Th17/Th1 (CCR6+ CXCR3+) and CCR6- CXCR3- cells is depicted. Supplementary Figure 5: Blood parameters in mCRC patients, D0 versus D15 Whole blood of metastatic colorectal cancer patient (mCRC) was sample before (D0) and after chemotherapy (D15) on EDAT-K2 tubes (BD Bioscience) and a complete blood count (CBC) was performed in Clinical Biology Unit (Centre George François Leclerc). Supplementary Figure 6: mRNA relative expression of genes involved in immunosuppression gMDSC and mMDSC were cell sorted from four mCRC patient blood. mRNA were extracted and the expression of Entpd1, Nt5e, Pdl1, Pdl2, Indo, Arg1 and Inos was determined using RT-qPCR. Supplementary Table 1: Patient and Healthy volunteer's characteristics Baseline characteristics (Age, Sex, Tumor origin, K-Ras and B-Raf status, number of metastatic sites, LDH, PA and CEA) of metastatic colorectal cancer patients (mCRC) and healthy volunteers. Supplementary Table 2: Human primer sequences used for RT-qPCR analysis List of primer used for mRNA relative expression in different myeloid subsets.</p>
Supplementary Data from Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells <i>In Vivo</i>
Authors: Bushnell Grace G. , Hardas Tejaswini P. , Hartfield Rachel M. , Zhang Yining , Oakes Robert S. , Ronquist Scott , Chen Haiming , Rajapakse Indika , Wicha Max S. , Jeruss Jacqueline S. , Shea Lonnie D. 
Published: April 2023

<p>1.	Fig S1: Gating strategy for flow cytometric assays 2.	Fig S2: Metastatic lung tumor burden for LUNG and LUNG2 lines developed from mice with and without scaffolds 3.	Fig S3: Mutational analysis of cell lines by whole exome sequencing 4.	Table S1: Table of unique mutations identified for each cell line by whole exome sequencing 5.	Table S2: Table of Gene ontology terms significantly altered in genes with mutations in SCAF, PT and LUNG cell lines 6.	Fig S4: RNAseq supplemental information 7.	Fig S5: Schematic of multiscale Hi-C analysis 8.	Fig S6: Hi-C does not reveal additional copy number variations, translocations, or breakpoint mutations between SCAF and PT cell line. 9.	Table S3: Table of KEGG pathways investigated for structure/function changes</p>
Supplementary Table 1 and Fig 1-8 including legends from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis
Authors: Zhang Yanyu , Cedervall Jessica , Hamidi Anahita , Herre Melanie , Viitaniemi Kati , D'Amico Gabriela , Miao Zuoxiu , Unnithan Ragaseema Valsala Madhavan , Vaccaro Alessandra , van Hooren Luuk , Georganaki Maria , Thulin Åsa , Qiao Qi , Andrae Johanna , Siegbahn Agneta , Heldin Carl-Henrik , Alitalo Kari , Betsholtz Christer , Dimberg Anna , Olsson Anna-Karin 
Published: April 2023

<p>Supplementary Table 1 and Fig 1-8 including legends. Table S1: Observed and expected numbers of Pf4-Cre;Pdgfbfl/fl embryos at different developmental stages.	Figure S1: Platelet-specific PDGFB knockout embryos display no obvious abnormalities. Figure S2: Platelet counts and proportion in peripheral blood from WT and pl-PDGFB KO mice. Figure S3: Generation of RIP1-Tag2 mice lacking PDGFB in platelets. Figure S4: Lack of platelet PDGFB does not affect the angiogenic switch or tumor growth in RT2 mice. Figure S5: Tumor vessels in MC38 colon carcinoma in mice with platelet-specific PDGFB ablation have impaired function and decreased pericyte coverage. Figure S6: Increased spontaneous lung metastasis in mice with platelet-specific PDGFB ablation in the HCmel12 melanoma model. Figure S7: Reduced pericyte coverage already in pre-tumorigenic tissue in mice lacking PDGFB in platelets. Figure S8: Expression of Cxcl3, Cxcl5, Cxcl7 and Cxcl15 in tumor tissue from Pf4-Cre- and Pf4-Cre+ mice.</p>
Supplemental Figure S1 from The Renin–Angiotensin System Mediates EGF Receptor–Vitamin D Receptor Cross-Talk in Colitis-Associated Colon Cancer
Authors: Dougherty Urszula , Mustafi Reba , Sadiq Farhana , Almoghrabi Anas , Mustafi Devkumar , Kreisheh Maggi , Sundaramurthy Sumana , Liu Weicheng , Konda Vani J. , Pekow Joel , Khare Sharad , Hart John , Joseph Loren , Wyrwicz Alice , Karczmar Gregory S. , Li Yan Chun , Bissonnette Marc 
Published: April 2023

<p>Supplemental Figure S1. Tarceva, an EGFR inhibitor, blocks Ang II induced HT29 cell proliferation. Cells (5,000) were plated on 96 well plates and allowed to adhere overnight. Cells were then treated with Tarceva (10 ÂµM), or vehicle for 2 hrs followed by Ang II (50 nM) or vehicle for 24 hrs. Cell proliferation was determined by Wst1 assay as described in the "Materials and Methods" (*,â€ p<0.05, compared to control; n=2 independent platings).</p>
Supplementary figure 1A from ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody–Drug Conjugate Treatment
Authors: Lamberts Laetitia E. , Menke-van der Houven van Oordt Catharina W. , ter Weele Eva J. , Bensch Frederike , Smeenk Michiel M. , Voortman Johannes , Hoekstra Otto S. , Williams Simon P. , Fine Bernard M. , Maslyar Daniel , de Jong Johan R. , Gietema Jourik A. , Schröder Carolien P. , Bongaerts Alphons H.H. , Lub-de Hooge Marjolijn N. , Verheul Henk M.W. , Sanabria Bohorquez Sandra M. , Glaudemans Andor W.J.M. , de Vries Elisabeth G.E. 
Published: April 2023

<p>A.	PET uptake in the circulation per cohort, as determined by region of interest drawn in left ventricle; cohort 1 (in blue) contained 2 patients (0 mg additional MMOT0530A), cohort 2 (in green) contained 9 patients (10 mg additional MMOT0530A). On X axis the different PET moments: 2, 4 and 7 days post injection. On the Y axis the mean SUVmax per cohort.</p>
Supplementary Figures from IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma
Authors: Ladomersky Erik , Zhai Lijie , Lenzen Alicia , Lauing Kristen L. , Qian Jun , Scholtens Denise M. , Gritsina Galina , Sun Xuebing , Liu Ye , Yu Fenglong , Gong Wenfeng , Liu Yong , Jiang Beibei , Tang Tristin , Patel Ricky , Platanias Leonidas C. , James C. David , Stupp Roger , Lukas Rimas V. , Binder David C. , Wainwright Derek A. 
Published: April 2023

<p>Supplementary figures and associated legends Supplementary Figure 1. In vitro GBM cell IDO1 metabolism with or without treatment of interferon-gamma (IFNï�§ï€©ï€ and/or IDO1 enzyme inhibitor, BGB-5777. Supplemental Figure 2. Mouse and human glioblastoma (GBM) cell IDO1 mRNA expression with or without IFNÎ³ treatment. Supplemental Figure 3. Monotherapeutic effects of BGB-5777 in subcutaneously-engrafted mouse cancer models. Supplemental Figure 4. Survival comparison of mice treated with BGB-5777, radiotherapy and either PD-1 mAb or PD-L1 mAb. Supplemental Figure 5. Cellular analysis of glioblastoma (GBM) at 3 weeks post-tumor cell engraftment and treated with trimodal therapy. Supplemental Figure 6. Metabolite analysis of mice with glioblastoma (GBM) at 3 weeks post-tumor cell engraftment and treated with BGB-5777 monotherapy.</p>
Assessment of android smartphones positioning in multi-GNSS/NavIC environment
Authors: Kuna Devadas , Perumalla Naveen Kumar 
Published: April 2023

Abstract
Positioning performance validates a smartphone’s antenna and chipset performance. This paper attempts to characterize the positioning performance of smartphones with dual-frequency GNSS chipsets compared to their counterparts using single-frequency chipsets. Furthermore, investigate the positioning performance of dual-frequency measurements using the NavIC L5 signal. A comparison of satellite geometry and position solution accuracy in relation to a known reference station is performed. The single-frequency positioning accuracy with 2DRMS (horizontal root mean square error) is about 5.11 m. Although, 2DRMS with dual-frequency measurements is 2.0 m. However, with the integration of NavIC with dual frequency measurements, the best position accuracy with 2DRMS is about 1.93 m over the observed location. It has been observed that single-frequency measurements can offer a MRSE (mean radial spherical error) precision of 2.75 m, whereas their dual-frequency counterparts can yield a precision of about 1.11 m, and with NavIC integration, it is around 1.05 m. During the observations, it should be noted that the NavIC L5 signals have modestly enhanced the positioning precision of smartphones. This analysis could be useful for fundamental Android GNSS research, smartphone positioning service and training communities.
Long non-coding RNA AL137789.1 promoted malignant biological behaviors and immune escape of pancreatic carcinoma cells
Authors: Wang Jing , Shen Yiyu , Wang Xiaoguang , Zhou Zhongcheng , Zhong Zhengxiang , Gu Tianyuan , Wu Bin 
Published: April 2023

Abstract
Our pre-investigation has revealed that long non-coding RNA (LncRNA) AL137789.1 has the potential to predict the survival of patients with pancreatic carcinoma (PCa). Accordingly, the mechanism underlying the implication of AL137789.1 in PCa is covered in the current study. The non-tumor and paired tumor tissues were collected. Kaplan–Meier curve was employed to estimate the survival of PCa patients with high or low expression of AL137789.1. The proliferation, migration, invasion, and cell cycle of PCa cells were determined, and the cytotoxicity of CD8+ T cells was evaluated as well. Levels of AL137789.1, E-cadherin, N-cadherin, and Vimentin were quantified. According to the experimental results, AL137789.1 was highly expressed in PCa and related to a poor prognosis of patients. Overexpressed AL137789.1 enhanced the proliferation, migration, and invasion of PCa cells, increased the cell population at G2/M and S phases yet decreased that in G0/G1 phase, and diminished the cytotoxicity of CD8+ T cells. Also, overexpressed AL137789.1 elevated levels of N-cadherin and Vimentin, while lessening E-cadherin levels. However, the silencing of AL137789.1 produced contrary effects. Collectively, lncRNA AL137789.1 plays a tumor-promotive role in PCa by enhancing the progression and immune escape.
Reference experiment on aerosol particle transport for dynamic situations
Authors: Merbold Sebastian , Hasanuzzaman Gazi , Buchwald Tom , Schunk Christoph , Schmeling Daniel , Volkmann André , Brinkema Robert , Hampel Uwe , Schröder Andreas , Egbers Christoph 
Published: April 2023

Abstract
To study airborne transport of aerosol particles by mixed convection and dynamic situations within a closed room, the Cottbus Aerosol Particle Reference Experiment (CARE) was built and equipped, which includes thermal manikins and a spreader dummy. For various flow configurations (location of spreader, heating bodies, windows opened, air ventilation with and without air purification systems) flow visualisation was performed, particulate matter sensors (PMS) measured local particle concentrations, head-mounted camera systems counted particle concentrations of individuals and finally, large field of view Shake-The-Box Particle Tracking delivered velocity fields. The comprehensive experimental configuration of different measurement systems are discussed in terms of their aerosol transport properties and quantitative results, effective application and comparative efficiency explaining the flow dynamics. The findings from these experiments also provide information under which circumstances particularly high concentrations of aerosol particles can be found on which locations.
Die „erbgesunde“ Familie als transatlantisches Projekt
Authors: Heinemann Isabel 
Published: April 2023

Abstract
Die Autorin untersucht eugenische Ehe- und Familienberatung als transnationale Verflechtungsgeschichte am Beispiel zweier Sozialexperten, des US-amerikanischen Eugenik-Pioniers und Familienberaters Paul B. Popenoe und des führenden NS-Rassenhygienikers und späteren Ordinarius für Humangenetik in Münster, Otmar Freiherr von Verschuer. In der langen Perspektive von den 1920er bis in die 1970er Jahre zeigt sich, dass die NS-Zeit keine Zäsur markierte. Vielmehr wurde auf beiden Seiten des Atlantiks eugenisches Wissen mobilisiert, um die Familie als Grundlage der Nation vor den Zumutungen der Moderne zu schützen. Die Quellengrundlage bilden wissenschaftliche Texte, Ratgeber, Briefwechsel, Institutsakten und ein bislang nicht genutzter Bestand an Patienten- und Beratungsakten.
Integrated and Organic Systems of Sustainable Agriculture in Poland Over the Period 2010–2020
Authors: Kokoszka Jakub 
Published: April 2023

Abstract

Subject and purpose of work
The purpose of the publication is to present two sustainable farming systems in Poland - the system of integrated production and organic farming in 2010 and 2020.

Materials and methods
Changes in the number of farms over the decade are analyzed. The study used statistical data published by the Central Statistical Office.

Results
A descriptive method was used, combined with the use of simple dynamics indicators, and a concise review of the literature on the subject was carried out. A decrease in the number of organic farms in 2020 compared to 2010 was noted, while the number of farms using the method of integrated agricultural production increased slightly. A large regional variation in the analyzed farming systems was also noted.

Conclusions
The results lead to the conclusion that sustainable agriculture is not recording the desired growth.
Artificial intelligence in healthcare: Threats to the fundamental values of our society
Authors: Zikmundová Klára 
Published: April 2023

Abstract
Summary
The article deals with the ethical and legal aspects of the use of artificial intelligence in healthcare. The author analyses key threats to the fundamental values held by the majority of democratic society and the human rights guaranteed by international human rights treaties, such as the European Convention on Human Rights. Emphasis is placed, in particular, on the risk of restricting patients’ autonomy due to an insufficient regulation of the use of clinical decision-support systems, a lack of humanistic care due to excessive use of care robots, a decline in human skills in specific fields of medicine, such as radiology, and the violation of privacy by extensive surveillance of social media. The article provides an overview of the benefits of artificial intelligence for healthcare, but also warns of the downsides, with the aim to encourage a debate that would lead to reasonable legal regulation.
Analysis of Appointment to Office of Central Bank Governor in the Member States of the EU
Authors: Kohajda Michael 
Published: April 2023

Abstract
Summary
This paper focuses on one of the fundamental aspects of central bank personal independence, namely how the central bank governor, as the head of the central bank acting for the bank, is appointed. The background of this paper is related to the recent appointment of a new Governor of the Czech National Bank, which has raised many questions among experts, but also instability in the financial markets. Within this starting point, the paper then poses the primary hypothesis of whether the Czech process of appointing the Governor of the Czech central bank is unusual among EU mMember States. An analysis of the process of appointing the governor in all other EU countries was conducted to answer this hypothesis. The results of this analysis were systematically arranged to identify which procedures prevail. Based on this analysis, it was concluded that the governor appointment process in the Czech Republic is unique.
A New Perspective on Residential Building Ventilation from the Point of View of Achieving the Desired Indoor Air Quality using Different Ventilation Systems
Authors: Straková Zuzana , Marková Júlia 
Published: April 2023

Abstract
The case study analyses a specifically described situation from the present and a summary of events from the past, finds alternative solutions, and decides on one of them. The target of such a detailed analysis was a concrete apartment building, which was still in the project phase; the efforts to change its proposed air conditioning system to a more energy-efficient one are the subject of the case study. Apartment buildings with modern technology installed in terms of sanitary equipment, heating, and simple methods of ventilation and cooling do not constitute part of the project.
Through a detailed analysis of the calculation of the heat losses through ventilation in the case of local and decentralised ventilation applied to one apartment unit, this failure to address modern solutions is remedied.
Application Of Video Media To Improve Student’s Interests In Learning Science Class V SDN 2 Tondon, Tondon District Toraja Utara Regency
Authors: Palullu Ceyzia , Rohana Rohana , AP Nurfaizah 
Published: April 2023

The problem in this research is the low interest in learning science class V SDN 2 Tondon, Tondon District, North Toraja Regency. The formulation in this research is how to apply leanrning video media to increase student’s interest in learning science class V SDN 2 Tondon, Tondon District, North Toraja Regency. Purpose of this research was to describe the application of learning video media in increasing student’s interest in learning science class V SDN 2 Tondon, Tondon District, North Toraja Regency. The approach chosen in the implementation of this research is a qualitative approach, this type of research is Classroom Action Research (CAR). Video media is a media that includes audio-visual that can display images and sound simultaneously. The advantages of video media which can display images along with sound make video media widely used as a medium in learning. Through video learning media will help students to understand subject matter in a more concrete. The research subjects were teachers and grade V students of SDN 2 Tondon, Tondon District, North Toraja Regency with a total of 22 students consisting of 12 girls and 10 boys. Teacher’s activity data and student activities were obtained through observation sheets and questionnaires on students' science learning interest. The results of interest in learning science in the first cycle of meetings 1 and 2 have not been successful but in the second cycle meetings 1 and 2 have increased and are categorized as successful. Thus it can be concluded that the application of instructional video media can increase interest in learning science class V SDN 2 Tondon, Tondon District, North Toraja Regency.