bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projections of flood regime changes over the upper-middle Huaihe River Basin in China based on CMIP6 models
Authors: Bian Guodong , Zhang Jianyun , Song Mingming , Qian Xin , Guan Tiesheng , Wang Guoqing 
Published: August 2023

Introduction: Climate change alters the hydrological cycle to different extents, in particular the intensification of extreme precipitation and floods, which has garnered more attention as a significant scientific issue in the last few decades. The last Coupled Model Inter-comparison Project 6 (CMIP6) was designed with new shared socioeconomic pathways (SSPs) to combine socioeconomic development with greenhouse gas emissions to project future climate.Method: In this study, we used 22 global climate models (GCMs) from CMIP6 to investigate future variations in extreme precipitation and temperature under SSP2-4.5 and SSP5-8.5 scenarios over the upper-middle Huaihe River Basin (UMHRB). Then, the modified Xinanjiang model integrating the flood control module was driven to obtain projections of the daily streamflow and to evaluate the future variations in flood regimes.Results: The results show that 1) the characteristics of future extreme precipitation, such as the average intensity and amount of annual precipitation and extreme precipitation, are projected to increase, and the average, maximum, and minimum temperature values also display substantial increasing trends in the future over the UMHRB; 2) warmer climate will lead to a more severe flood magnitude under the SSP5-8.5 scenario in the far future (2071–2100) over the UMHRB. The results of the multi-model ensemble show that the annual maximum flood peaks (15-day flood volumes) of Wangjiaba and Wujiadu stations are projected to increase by 46.4% (43.1%) and 45.4% (51.1%), respectively, in the far future (2071–2100) under the SSP5-8.5 scenario; and 3) variations in the flood frequency tend to resemble variations in flood magnitude, and the return period of the design flood will obviously decrease under future climate scenarios. For instance, in the far future, under SSP5-8.5 scenarios, the return period of the design flood with a 100-year return period will become 38 years and 31 years for Wangjiaba and Wujiadu stations, respectively.Discussion: The study enhances a more realistic understanding that the occurrence of future extreme precipitation and floods is projected to be more frequent and severe, thereby resulting in an urgent imperative to develop pertinent adaptation strategies to enhance social resilience toward the warming climate.
Toxicopathic effects of waterborne Cd in sole juveniles, a prospective pollution monitoring sentinel for estuarine ecosystems
Authors: Briaudeau Tifanie , Guerrero-Limón Gustavo , Zorita Izaskun , Marigómez Ionan , Izagirre Urtzi 
Published: August 2023

IntroductionEstuarine ecosystems are under high anthropogenic pressure and receive a wide Q7 variety of contaminants, including metals. They can remain trapped in estuarine sediments at high concentrations for long periods but eventually they can be released to the overlying water and become toxic for the resident benthic biota. As a consequence, biomonitoring programs surveying the health status of estuaries and coastal areas count with benthic species for the assessment of health disturbances in these specific ecosystems. The present investigation aims at recognizing toxicopathic effects elicited in estuarine life stages of the benthic fish Solea senegalensis on exposure to waterborne Cd, a model compound for metal contamination.MethodsBiological responses to metal exposure were assessed based on the application of a “biomarker + histopathology” approach. Two-year old sole juveniles were exposed to various concentrations of waterborne Cd for 3 and 7 days (Control; Low Cd: 1 µg/l; Mid Cd: 10 µg/l and High Cd: 1000 µg/l). Liver samples were collected for chemical analysis at day 7. Biological samples were collected at days 3 and 7 for biochemical (brain and liver), histochemical (liver) and histopathological analysis (liver, gills and gonad).ResultsBrain acetyl cholinesterase was inhibited after 7 days exposure, indicating neurotoxic effects on exposure to 1000 µg Cd/l. Hepatic catalase and glutathione-Stransferase were induced at day 3 and inhibited at day 7, which suggests a bell-shaped response. A dose-dependent lysosomal membrane destabilization in hepatocytes was recorded at day 7. In parallel, histopathological lesions in gills, liver and gonad were more frequent at day 7 in soles exposed to high Cd concentrations.DiscussionOverall, the “biomarker + histopathology” approach revealed that waterborne Cd causes toxicopathic effects in sole juveniles upon exposure to environmentally relevant concentrations (10 µg Cd/l). The effects were clearly time dependent, and thus it is conceivable that more severe biological effects would be elicited by these low concentrations of Cd at longer exposure periods. Therefore, biomarkers and histopathology in combination provide early-warning indications of altered health status after waterborne Cd exposure in sole juveniles, a prospective sentinel for biological effects assessment of metal contamination in pollution monitoring programs in estuaries and coastal areas.
Central retinal vein occlusion in young population: risk factors and outcomes
Authors: Berguig Jordan , Abdelmassih Youssef , Azar Georges , Lafolie Justine , Alonso Anne Sophie , Bonnin Sophie , Vasseur Vivien , Mauget-Faysse Martine 
Published: August 2023

ObjectiveTo evaluate the risk factors and outcomes of central retinal vein occlusion (CRVO) in young patients (&lt; 40 years).MethodsIn this retrospective monocentric case series, we included young patients (&lt;40 years) with CRVO. Patients’ medical files were analyzed focusing on demographic characteristics, suspected risk factors, ophthalmic work-up, visual acuity (VA), treatment, and outcomes.ResultsA total of 54 eyes of 52 patients were included. Central retinal vein occlusion was considered idiopathic in 13 patients (25%). The main risk factors identified were ocular hypertension (20.4%), inflammation (20.4%), high blood pressure (14.8%), and coagulation abnormality (11.1%). Final VA was lower in patients with high blood pressure and inflammation when compared to patients with no risk factor (p = 0.03 and 0.04, respectively). Intravitreal injections were needed in 23 eyes (42.6%) and 19 eyes (35.2%) received panretinal photocoagulation treatment.ConclusionCentral retinal vein occlusion is frequently associated with risk factors in young patients (75% of patients). In addition to the usual factors found in older patients, such as ocular hypertension and high blood pressure, coagulation abnormality and inflammation were also among the risk factors identified. Young patients with CRVO should be evaluated for the presence of risk factors and patients with high blood pressure or inflammatory findings should be followed carefully since they have a worse outcome.
Assessing cardiorespiratory interactions via lagged joint symbolic dynamics during spontaneous and controlled breathing
Authors: Cairo Beatrice , Bari Vlasta , Gelpi Francesca , De Maria Beatrice , Porta Alberto 
Published: August 2023

Introduction: Joint symbolic analysis (JSA) can be utilized to describe interactions between time series while accounting for time scales and nonlinear features. JSA is based on the computation of the rate of occurrence of joint patterns built after symbolization. Lagged JSA (LJSA) is obtained from the more classical JSA by introducing a delay/lead between patterns built over the two series and combined to form the joint scheme, thus monitoring coordinated patterns at different lags.Methods: In the present study, we applied LJSA for the assessment of cardiorespiratory coupling (CRC) from heart period (HP) variability and respiratory activity (R) in 19 healthy subjects (age: 27–35 years; 8 males, 11 females) during spontaneous breathing (SB) and controlled breathing (CB). The R rate of CB was selected to be indistinguishable from that of SB, namely, 15 breaths·minute−1 (CB15), or slower than SB, namely, 10 breaths·minute−1 (CB10), but in both cases, very rapid interactions between heart rate and R were known to be present. The ability of the LJSA approach to follow variations of the coupling strength was tested over a unidirectionally or bidirectionally coupled stochastic process and using surrogate data to test the null hypothesis of uncoupling.Results: We found that: i) the analysis of surrogate data proved that HP and R were significantly coupled in any experimental condition, and coupling was not more likely to occur at a specific time lag; ii) CB10 reduced CRC strength at the fastest time scales while increasing that at intermediate time scales, thus leaving the overall CRC strength unvaried; iii) despite exhibiting similar R rates and respiratory sinus arrhythmia, SB and CB15 induced different cardiorespiratory interactions; iv) no dominant temporal scheme was observed with relevant contributions of HP patterns either leading or lagging R.Discussion: LJSA is a useful methodology to explore HP–R dynamic interactions while accounting for time shifts and scales.
Cranial nerve involvement among COVID-19 survivors
Authors: Heidari Mohammad Eghbal , Nazemi Pershang , Feizabad Elham , Beiranvand Farzaneh , Afzali Mahdieh 
Published: August 2023

IntroductionCOVID-19 was first reported in November 2019 in China and rapidly spread across the globe. COVID-19 causes neurologic symptoms and complications, which may persist even after recovery in patients. The objective of this research was to determine the involvement of cranial nerves in COVID-19 survivors.MethodThis was a retrospective study. The study was conducted between March and July of 2022. The analysis included 98 patients with a certain positive polymerase chain reaction. SPSS software version 19 was utilized for data analysis.ResultsThe average age of the participants was 40.47 years (8.81). The olfactory nerve was found to be the most frequently involved cranial nerve (36.7%). Over 20% of participants had a taste disorder. The findings from the regression analysis indicated that lung involvement and age have a direct and significant relationship with cranial nerve involvement and can serve as its predictors (p = 0.001).ConclusionIt seems that cranial nerve involvement was sustained in COVID-19 patients who survived. In addition, elderly patients and patients with severe illnesses were more likely to show cranial symptoms. It is necessary to monitor COVID-19 survivors for neurological symptoms.
Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review
Authors: Hamadelseed Osama , Chan Mike K. S. , Wong Michelle B. F. , Skutella Thomas 
Published: August 2023

ObjectivesWe critically review research findings on the unique changes in brain structure and cognitive function characteristic of Down syndrome (DS) and summarize the similarities and differences with other neurodevelopmental disorders such as Williams syndrome, 22q11.2 deletion syndrome, and fragile X syndrome.MethodsWe conducted a meta-analysis and systematic literature review of 84 studies identified by searching PubMed, Google Scholar, and Web of Science from 1977 to October 2022. This review focuses on the following issues: (1) specific neuroanatomic and histopathological features of DS as revealed by autopsy and modern neuroimaging modalities, (2) language and memory deficits in DS, (3) the relationships between these neuroanatomical and neuropsychological features, and (4) neuroanatomic and neuropsychological differences between DS and related neurodevelopmental syndromes.ResultsNumerous post-mortem and morphometric neuroimaging investigations of individuals with DS have reported complex changes in regional brain volumes, most notably in the hippocampal formation, temporal lobe, frontal lobe, parietal lobe, and cerebellum. Moreover, neuropsychological assessments have revealed deficits in language development, emotional regulation, and memory that reflect these structural changes and are more severe than expected from general cognitive dysfunction. Individuals with DS also show relative preservation of multiple cognitive, linguistic, and social domains compared to normally developed controls and individuals with other neurodevelopmental disorders. However, all these neurodevelopment disorders exhibit substantial heterogeneity among individuals.ConclusionPeople with Down syndrome demonstrate unique neurodevelopmental abnormalities but cannot be regarded as a homogenous group. A comprehensive evaluation of individual intellectual skills is essential for all individuals with neurodevelopment disorders to develop personalized care programs.
The time is ripe for the renaissance of autism treatments: evidence from clinical practitioners
Authors: Torres Elizabeth B. , Twerski Goldie , Varkey Hannah , Rai Richa , Elsayed Mona , Katz Miriam Tirtza , Tarlowe Jillian 
Published: August 2023

IntroductionRecent changes in diagnostics criteria have contributed to the broadening of the autism spectrum disorders and left clinicians ill-equipped to treat the highly heterogeneous spectrum that now includes toddlers and children with sensory and motor issues.MethodsTo uncover the clinicians’ critical needs in the autism space, we conducted surveys designed collaboratively with the clinicians themselves. Board Certified Behavioral Analysts (BCBAs) and developmental model (DM) clinicians obtained permission from their accrediting boards and designed surveys to assess needs and preferences in their corresponding fields.Results92.6% of BCBAs are open to diversified treatment combining aspects of multiple disciplines; 82.7% of DMs also favor this diversification with 21.8% valuing BCBA-input and 40.6% neurologists-input; 85.9% of BCBAs and 85.3% of DMs advocate the use of wearables to objectively track nuanced behaviors in social exchange; 76.9% of BCBAs and 57.0% DMs feel they would benefit from augmenting their knowledge about the nervous systems of Autism (neuroscience research) to enhance treatment and planning programs; 50.0% of BCBAs feel they can benefit for more training to teach parents.DiscussionTwo complementary philosophies are converging to a more collaborative, integrative approach favoring scalable digital technologies and neuroscience. Autism practitioners seem ready to embrace the Digital-Neuroscience Revolutions under a new cooperative model.
Clinicopathological and prognostic significance of heat shock proteins in hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Xiang Dan , Jiang Mengdan , Chen Ya , Liu Chengjiang , Li Leilei 
Published: August 2023

BackgroundOverexpression of heat shock proteins (HSPs) has been observed in a wide range of human tumors, and there is an increasing evidence demonstrated that HSPs play a key role in tumor progression. Several studies were conducted to explore the clinicopathological characteristics and prognostic value of HSPs in hepatocellular carcinoma (HCC), but the results remain controversial. To address this gap, we conducted a systematic review and meta-analysis.MethodsThe eligible literature was obtained from PubMed, Cochrane library, Web of science, Embase, Chinese National Knowledge Infrastructure and Wan Fang databases. We used the odds ratio (OR) and hazard ratio (HR) as the suitable parameters to assess the clinicopathological features and prognostic value of HSPs in HCC patients.ResultsThe meta-analysis results showed that HSPs expression was associated with overall survival (OS) of HCC patients (HR = 1.61, 95%CI = 1.22-2.13, P=0.001, I2 = 62.7%). In addition, the pooled results suggested that HSPs expression was significantly correlated with tumor differentiation (OR = 1.33, 95%CI = 1.08-1.65, P = 0.907), vascular invasion (OR = 1.31, 95%CI = 1.02-1.69, P = 0.921) and lymphatic metastasis (OR=1.98, 95%CI= 1.70-2.31, P = 0.740). Meanwhile, the subgroup analysis showed a significant correlation between the expression of HSP27 (HR=1.69, 95%CI = 1.24-2.31, P = 0.674) and HSP90α (HR=2.03, 95%CI = 1.73-2.40, P = 0.743) with OS of HCC patients.ConclusionsOur meta-analysis confirms that HSPs expression is closely associated with a worse prognosis in HCC patients, and may be directly involved in tumor differentiation and distant metastasis. In addition, the subgroup analysis results demonstrate that the expression of HSP27 and HSP90α can be served as potential prognostic predictors of HCC.
Orlistat exerts anti-obesity and anti-tumorigenic effects in a transgenic mouse model of endometrial cancer
Authors: Xu Guangxu , Zhao Ziyi , Wysham Weiya Z. , Roque Dario R. , Fang Ziwei , Sun Wenchuan , Yin Yajie , Deng Boer , Shen Xiaochang , Zhou Chunxiao , Bae-Jump Victoria 
Published: August 2023

IntroductionAmong all cancers, endometrial cancer is most strongly associated with obesity, with more than 65% of endometrial cancers attributable to obesity and being overweight. Fatty acid synthase (FAS), a key lipogenic enzyme, is expressed in endometrial cancer tumors and is associated with a worse prognosis for this disease. Orlistat, an FAS inhibitor, is an FDA-approved weight loss medication that has demonstrated anti-tumor activity in a variety of preclinical cancer models.MethodsIn this study, the Lkb1fl/flp53fl/fl mouse model of endometroid endometrial cancer was exposed to three diet interventions, including a high fat diet (obese), a low fat diet (lean) and switch from a high fat to a low fat diet, and then exposed to orlistat or placebo.ResultsThe mice fed a high-fat diet had significantly increased body weight and tumor weight compared to mice fed a low-fat diet. Switching from a high-fat diet to a low fat diet led to a reduction in mouse weight and suppressed tumor growth, as compared to both the high fat diet and low fat diet groups. Orlistat effectively decreased body weight in obese mice and inhibited tumor growth in obese, lean, and the high fat diet switch to low fat diet mouse groups through induction of apoptosis. Orlistat also showed anti-proliferative activity in nine of 11 primary cultures of human endometrial cancer.DiscussionOur findings provide strong evidence that dietary intervention and orlistat have anti-tumor activity in vivo and supports further investigation of orlistat in combination with dietary interventions for the prevention and treatment of endometrial cancer.
Case Report: A case of complete response to entrectinib in NTRK fusion gene-positive parotid gland cancer
Authors: Moriyama Etsuko , Nagasu Sachiko , Tanaka Toshimitsu , Shimotsuura Yasutaka , Ono Takeharu , Umeno Hirohito , Akiba Jun , Kawahara Akihiko , Fujita Fumihiko , Kawaguchi Takumi , Miwa Keisuke 
Published: August 2023

IntroductionExpression of the NTRK gene is rare in solid tumors but is highly prevalent in salivary gland secretory carcinomas. Here, we report a case of a complete response to entrectinib in a patient with NTRK fusion gene-positive parotid carcinoma.Case descriptionThe patient was a 44-year-old man who underwent total left parotidectomy and left cervical lymph node dissection for a left parotid tumor at 24 years of age. The histopathological diagnosis was mammary analog secretory carcinoma. Postoperatively, the patient received only radiation therapy. Sixteen years after the surgery, the patient became aware of a mass in the left parotid region. A close examination revealed local recurrence and multiple cervical lymph node metastases. S-1 monotherapy was started as chemotherapy but was discontinued 3 years later because of disease progression. As there was no standard treatment, a comprehensive genomic profiling test using a next-generation sequencer was performed, and the ETV6-NTRK3 fusion gene was identified. Entrectinib, an NTRK inhibitor, was immediately administered at a dose of 600 mg/day. The local recurrence rapidly shrank grossly from the beginning of treatment, and a complete response was observed 6 months later. However, creatinine levels exhibited an increase at week 68 of treatment; consequently, entrectinib dosage was lowered to 400 mg/day, leading to an immediate improvement in creatinine levels. Entrectinib was associated with additional side effects, including dysgeusia, fatigue, dizziness, and weight gain, all of which were also alleviated by the reduction in entrectinib dose. Thirty months after treatment initiation, the patient maintained a complete response and continued to receive entrectinib.ConclusionThe NTRK fusion gene should always be checked in the presence of salivary gland secretory carcinoma.
Efficacy and safety of total glucosides of paeony in the treatment of recurrent aphthous ulcers: a single-center, double-blind, randomized, placebo-controlled clinical trial
Authors: Liu Zijian , Guo Xiang , Li Shufang , Lu Mingxing , Guo Qianyun , Liu Xingyun , Wang Yutian , Han Ying , Liu Hongwei 
Published: August 2023

Introduction: There has been a lack of treatments available to lower the frequency of recurrent aphthous ulcers (RAUs) until now. Total glucosides of paeony (TGP) is a botanical drug extracted from the dried roots of Paeonia lactiflora Pall. [Ranunculaceae; Paeoniae Radix Alba]. This study aims to evaluate the efficacy and safety of TGP in the treatment of RAU.Methods: This study was registered with the Chinese Clinical Trial Registry (ChiCTR1900025623). Patients were randomly assigned to the TGP or placebo group and treated with 1.8 g/day for 24 weeks. Participants were observed for a total of 36 weeks and were asked to record ulcer severity, medication, and adverse reactions in the form of diaries or apps every day. The primary outcome was the monthly ulcer-free interval.Results: A total of 79 individuals were enrolled, with 40 assigned to the TGP group and 39 to the placebo group. The dropout rate was 18.18%. In the TGP group, the monthly ulcer-free interval was significantly longer than baseline (median, 9.6 days) since weeks 13–24 (median, 18.5 days) (p &lt; 0.05), and after discontinuation, it was further prolonged (median, 24.7 days) than in weeks 13–24 (p &lt; 0.05). In addition, the monthly ulcer-free interval was longer in the TGP group than in the placebo group (median, 15.9 days) at weeks 25—36 (p &lt; 0.001). There were better improvements in the monthly number of ulcers and monthly area of ulcers, and visual analog scoring in the TGP group at weeks 25—36 (p &lt; 0.001).Conclusion: TGP had a good long-term therapeutic effect on RAU with frequent occurrence.Systematic Review Registration:www.chictr.org.cn, identifier ChiCTR1900025623.
New advances in clinical application of neostigmine: no longer focusing solely on increasing skeletal muscle strength
Authors: Si Shangkun , Zhao Xiaohu , Su Fan , Lu Hongxiu , Zhang Dongbin , Sun Li , Wang Fulei , Xu Li 
Published: August 2023

Neostigmine is a clinical cholinesterase inhibitor, that is, commonly used to enhance the function of the cholinergic neuromuscular junction. Recent studies have shown that neostigmine regulates the immune-inflammatory response through the cholinergic anti-inflammatory pathway, affecting perioperative neurocognitive function. This article reviews the relevant research evidence over the past 20 years, intending to provide new perspectives and strategies for the clinical application of neostigmine.