bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can a Multidisciplinary Endocrine Clinic be Beneficial for Patients and Surgeons?
Authors: Kennedy Alexis , Zmijewski Polina V. , Bahl Deepti , Banerjee Ronadip , Buczek Erin , Fazendin Jessica , Chen Herbert , Lindeman Brenessa 
Published: February 2023

Background Multidisciplinary clinics are expected to improve patient care by enhancing efficiency for both patients and care providers. We hypothesized that while these clinics are an efficient use of time for patients, they can limit a surgeon’s productivity. Methods A retrospective review was performed for patients evaluated in a Multidisciplinary Endocrine Tumor Clinic (MDETC) and Multidisciplinary Thyroid Cancer Clinic (MDTCC) from 2018 to 2021. Time from evaluation to surgery and prevalence of surgery were evaluated. Patients were compared to those evaluated in a surgeon-only endocrine surgery clinic (ESC) from 2017 to 2021. Chi-square and t-tests were used to test significance. Results Patients referred to the ESC underwent surgery more often than those referred to either multidisciplinary clinic (ESC 79.5%, MDETC 24.6%, MDTCC 7%; P < .001) but had a significantly longer delay between appointment and operation (ESC 19.9 days, MDETC 3.3 days, MDTCC 16.4 days; P < .001). Patients had a longer wait from referral to appointment for the MDCs (ESC 22.6 days, MDETC: 44.5, MDTCC 33; P < .05). There was no significant difference in miles traveled by patients to any clinic. Conclusion Multidisciplinary clinics can provide fewer appointments and faster time to surgery for patients but may lead to longer wait time from referral to appointment and fewer overall surgeries than endocrine surgeon-only clinics.
Experimental investigation of crossflow air effect on spray characteristics of gelled Jet-A1 fuel using an internally impinging air-blast atomizer
Authors: Pandian Balaguru , Das Rajarshi 
Published: February 2023

The present study aims to experimentally analyse the influence of crossflow aerodynamic parameters on the spray characteristics of gelled Jet-A1 fuel. A Jet-A1 gel fuel is prepared by combining 85 percentage by weight (wt. %) of Jet-A1 liquid as base fuel with an organo-gel solution having Thixatrol ST (7.5 wt. %) as gelling agent and Rectified xylene (7.5 wt. %) as solvent. Shear flow test is performed on the gel fuel using a rotational rheometer, to understand its non-Newtonian rheological properties. An internally impinging air blast atomizer is used to study the gel spray characteristics by injecting the gel fuel transversely into the subsonic cross flowing airstream environment. Gel spray images are captured by generating a laser sheet along the midplane of the test section across the crossflow air stream direction using the Laser Sheet Photography (LSP) technique. The captured gel spray images are used to visualize the gel spray structure in both spray axis as well as the crossflow air stream direction. These images are then investigated by developing an algorithm in MATLAB using an image processing tool. By incorporating the canny edge detection method into the MATLAB code, gel spray characteristics such as droplet size distribution, Sauter-mean-diameter, Arithmetic-mean-diameter, windward trajectories, and maximum penetration height are determined. Further, the effect of aerodynamic parameters such as crossflow Reynolds’ number and aerodynamic Weber number on the gel spray characteristics are investigated. Droplet size distribution and maximum penetration height of gelled Jet-A1 spray revealed its dependence on crossflow Reynolds’ number. Sauter-Mean-Diameter of gel droplets and windward trajectories of the gel spray decreases significantly as the aerodynamic Weber number increases. Thus, it can be concluded that the fineness of the spray is also a function of the crossflow aerodynamic parameters other than the atomizer.
Implementation Costs of Technology-Enhanced Transitional Palliative Care for Rural Caregivers
Authors: Kaufman Brystana G. , Holland Diane E. , Vanderboom Catherine E. , Ingram Cory , Wild Ellen M. , Dose Ann Marie , Stiles Carole , Gustavson Allison M. , Chun Alice , Langan Erica M. , Baer-Benson Henry A. , Mandrekar Jay , Griffin Joan M. 
Published: February 2023

Objectives Compared to urban family caregivers (FCG), rural FCG experience greater burdens accessing coordinated care for their loved ones during and after hospitalization. The impact of technology-enhanced transitional palliative care (TPC) on caregiver outcomes is currently being evaluated in a randomized control trial. This study evaluates resource use and health system costs of this FCG-focused TPC intervention and potential Medicare reimbursement mechanisms. Methods Rural caregivers of hospitalized patients were randomized into an 8-week intervention consisting of video visits conducted by a registered nurse certified in palliative care, supplemented with phone calls and texts (n = 215), or attentional control. Labor costs were estimated for a registered nurse and compared to scenario analyses using a nurse practitioner or social worker wages. Medicare reimbursement scenarios included Transitional Care Management (TCM) and Chronic Care Management (CCM) CPT codes. Results In the base case, TPC cost was $395 per FCG facilitated by a registered nurse, compared to $337 and $585 if facilitated by a social worker or nurse practitioner, respectively. Mean Medicare reimbursement in the TCM-only scenario was $322 and $260 for high or moderate complexity patients, respectively. Reimbursement in the CCM only scenario was $348 and $274 for complex and non-complex patients, respectively. Reimbursement in the TCM+CCM scenario was $496 and $397, for high/complex and moderate/non-complex patients, respectively. Conclusion TPC is a feasible, low cost and sustainable strategy to enhance FCG support in rural areas. Potential reimbursement mechanisms are available to offset the costs to the health system for providing transitional palliative care to caregivers of patients recently hospitalized.
Predictors of Engagement Barriers for Adolescent ADHD Treatment
Authors: Johansson Margaret , Greenwood Lydia , Torres Antunez Gissell , Link Kara , Sibley Margaret H. 
Published: February 2023

Objective: The purpose of this study was to understand patient characteristics that predict engagement barriers during behavior therapy for ADHD. Method: Participants were 121 adolescents with ADHD and parents who received evidence-based behavior therapy for ADHD. Multiple regression examined relationships between six independent variables and frequency of barriers. Results: ODD comorbidity and parental ADHD predicted higher frequency of overall barriers. With respect to barriers subtypes, these variables also predicted higher frequencies of cognitive, teen, early-treatment and mid-treatment barriers. Late-treatment, ODD predicted higher frequency of barriers, while minority status predicted lower barriers. Conclusions: Adolescents diagnosed with ADHD and comorbid ODD, or who have parents that are also diagnosed with ADHD, are at greatest risk for engagement barriers during behavior therapy. During all phases of treatment, this patient subgroup would benefit from enhancements to standard behavior therapy that focus on therapeutic engagement—particularly targeting teen beliefs about treatment.
Ethical and legal dilemmas experienced by Israeli social workers during the COVID-19 pandemic
Authors: Segal Michal , Gur Ayelet 
Published: February 2023

Summary The Covid-19 pandemic (Coronavirus) has created complex challenges for recipients of social services worldwide and for the social workers entrusted with assisting them. This article presents a study of the decision-making process of Israeli social workers when coping with ethical and legal dilemmas arising during the pandemic. Method A qualitative self-administered survey was completed by 478 social workers who worked during the Covid-19 pandemic. Thematic analysis was used to identify major themes. Findings We identified three major themes. The first theme was concern over the potential violation of the service users' privacy and confidentiality due to the unique circumstances of the pandemic. The second theme was the danger to the social workers' health when serving clients during the pandemic. The third theme focused on difficulties in providing professional services during the pandemic. Applications We present several recommendations to help social workers cope with ethical and legal decisions in national emergencies.
YouTube as a Source of Patient Information for Cubital Tunnel Syndrome: An Analysis of Video Reliability, Quality, and Content
Authors: Lama Christopher J. , Hartnett Davis A. , Donnelly Joseph C. , Yang Daniel S. , Kosinski Lindsay R. , Katarincic Julia A. , Gil Joseph A. 
Published: February 2023

Background: This study seeks to examine the reliability, quality, and content of YouTube videos on cubital tunnel syndrome, on which there is presently a paucity of information. Methods: The top 50 unique YouTube videos by relevance resulting from the Boolean search term “cubital tunnel + cubital tunnel syndrome” were identified, with video properties for analysis including source, upload date, duration, views, and comments. Content was assessed using the Journal of American Medical Association ( JAMA) criteria, the Global Quality Score (GQS), and a “Cubital Tunnel–Specific Score” (CTSS). Results: The average video saw 72 108 ± 199 362 views, with videos produced by allied (nonphysician) health professionals demonstrating the highest mean views (111 789 ± 294 471 views). Videos demonstrated low mean JAMA scores (2.4/4 ± 0.7), GQS (2.8/5 ± 1.3), and CTSS (7.5/21 ± 4.3), with academic and nonacademic physician videos demonstrating significantly greater mean GQS and CTSS scores when compared with videos by allied health professionals. Positive independent predictors for GQS included academic sources (β = 1.871), nonacademic physician sources (β = 1.651), and video duration (β = 0.102), which were likewise positive predictors for CTSS (β = 4.553, 4.639, 0.374). Content relating to surgical techniques or approaches for cubital tunnel decompression had the greatest CTSS scores (11.2 [4.2]). Conclusions: YouTube is a source of highly accessible information on cubital tunnel syndrome, although the average video presents generally poor and inadequate information. Directing patients toward higher quality video resources can be a meaningful component of patient education.
Design of a Real-Time Physical Activity Detection and Classification Framework for Individuals With Type 1 Diabetes
Authors: Cho Sunghyun , Aiello Eleonora M. , Ozaslan Basak , Riddell Michael C. , Calhoun Peter , Gal Robin L. , Doyle Francis J. 
Published: February 2023

Background: Managing glycemia during and after exercise events in type 1 diabetes (T1D) is challenging since these events can have wide-ranging effects on glycemia depending on the event timing, type, intensity. To this end, advanced physical activity-informed technologies can be beneficial for improving glucose control. Methods: We propose a real-time physical activity detection and classification framework, which builds upon random forest models. This module automatically detects exercise sessions and predicts the activity type and intensity from tri-axial accelerometer, heart rate, and continuous glucose monitoring records. Results: Data from 19 adults with T1D who performed structured sessions of either aerobic, resistance, or high-intensity interval exercise at varying times of day were used to train and test this framework. The exercise onset and completion were both predicted within 1 minute with an average accuracy of 81% and 78%, respectively. Activity type and intensity were identified within 2.38 minutes and from the exercise onset. On participants assigned to the test set, the average accuracy for activity type and intensity classification was 74% and 73%, respectively, if exercise was announced. For unannounced exercise events, the classification accuracy was 65% for the activity type and 70% for its intensity. Conclusions: The proposed module showed high performance in detection and classification of exercise in real-time within a minute of exercise onset. Integration of this module into insulin therapy decisions can help facilitate glucose management around physical activity.
A Preliminary Study in Immune Response of BALB/c and C57BL/6 Mice with a Locally Allergic Rhinitis Model
Authors: Zhang Qidi , Zhu Wanting , Zou Zhixin , Yu Wenting , Gao Pei , Wang Ying , Chen Jianjun 
Published: February 2023

Background BALB/c and C57BL/6 mouse strains are commonly used in allergy research. The current study investigated the immunological differences between these two mouse strains with a locally allergic rhinitis model. Methods Eighteen BALB/c and eighteen C57BL/6 mice received different doses of ovalbumin (OVA) intranasally for eight weeks (each mouse strain has three subgroups, 25 mg/mL group, 0.25 mg/mL group, and the PBS group). The allergic symptoms, OVA-specific serum antibody (IgE, IgG1, IgG2a), cytokines (IL-4, IFN-γ, IL-10) in the splenic culture supernatant, infiltrating eosinophils and goblet cells in local nasal mucosa were measured. RNA-seq technology was applied to detect differential gene expression in the local nasal mucosa. Results With the same dose of OVA stimulation, the exacerbation of allergic symptoms was more pronounced in C57BL/6 than in BALB/c. BALB/c serum IgE, IgG1, and IgG2a gradually increased, and C57BL/6 produced fewer serum antibodies IgE and IgG1, while IgG2a never increased. BALB/c spleen cell culture supernatant IL-4 and IL-10 increased with increasing dose, and IFN-γ increased significantly in the intermediate dose group, while IL-4, IL-10, and IFN-γ did not increase in C57BL/6. The infiltration of eosinophils and goblet cells in both mice was proportional to the dose, while C57BL/6 was elevated more than BALB/c. RNA-seq suggested that the innate immune response, immune system process function, Jun kinase (JNK) pathway, and MAPKK pathway were upregulated in C57BL/6 compared to BALB/c. The core genes responsible for the differential immune response in both mice with allergic rhinitis were Kng2, Kng1, Gnb3, Lpar3, Lpar1, Pik3r1, Pf4, Apob, Rps9, and Fbxo2. Conclusion There are significant differences in the immunologic responses between BALB/c mice and C57BL/6 mice. BALB/c mice developed mild local allergic inflammatory reactions and strong systemic immune responses. In contrast, C57BL/6 mice had stronger local allergic inflammatory responses and relatively mild systemic immune responses. Different mice strains can be selected according to the research purpose.
The efficacy of telemedicine for pain management in patients with cancer: a systematic review and meta-analysis
Authors: Chen Wenyu , Huang Jie , Cui Zhifang , Wang Lei , Dong Liang , Ying Weifeng , Zhang Ye 
Published: February 2023

Background: Pain is the most common cancer-related symptom, but it is often undertreated. Telemedicine is widely used in cancer treatment, but its effectiveness is uncertain. Objective: We aimed to evaluate the impact of telemedicine intervention on pain in patients with cancer. Design: Methodological quality and risk-of-bias evaluation were conducted, and the sources of heterogeneity were explored through subgroup analysis and sensitivity analysis. Data Sources and Methods: PubMed, Embase, Web of Science, Cochrane Library, and clinical trial databases were searched up to 16 August 2022. Randomized controlled trials of the impact of telemedicine intervention regarding pain in patients with cancer were included, and the results related to pain were extracted. Results: Twenty-one randomized controlled trials were selected from 1810 articles. A total of 1454 patients received telemedicine interventions, and 2213 received conventional medical services. Telemedical intervention had a positive effect on improving pain intensity [standard mean deviation (SMD) = −0.28, 95% confidence interval (CI): −0.49 to −0.06, p = 0.01] and pain interference (SMD = −0.41, 95% CI: −0.54 to −0.28, p < 0.00001), with statistical difference between the two groups. The subgroup analysis results showed that the telemedicine subgroup based on an application (SMD = −0.54, 95% CI: −0.91 to −0.18, p = 0.004) and the subgroup with intervention time ⩾ 6 months (SMD = −0.33, 95% CI: −0.52 to −0.13, p = 0.001), both demonstrated significant improvement regarding pain intensity, with significant statistical difference between the two groups. When the follow-up time was ⩾ 6 months, there was no significant difference (SMD = −0.24, 95% CI: −0.55 to 0.07, p = 0.13). Conclusion: Compared with conventional medical services, telemedicine intervention can improve the pain of patients with cancer and is effective and acceptable regarding symptom monitoring. Integrating telemedicine interventions into cancer pain management may be a feasible option. But its long-term effects still need to be confirmed with more high-quality randomized controlled trials in the future. Registration: https://www.crd.york.ac.uk/PROSPERO/ ; CRD42022361990
Axonal and myelin changes and their inter-relationship in the optic radiations in people with multiple sclerosis
Authors: Krijnen Eva A. , Ngamsombat Chanon , George Ilena C. , Yu Fang F. , Fan Qiuyun , Tian Qiyuan , Huang Susie Y. , Klawiter Eric C. 
Published: February 2023

Background The imaging g-ratio, estimated from axonal volume fraction (AVF) and myelin volume fraction (MVF), is a novel biomarker of microstructural tissue integrity in multiple sclerosis (MS). Objective To assess axonal and myelin changes and their inter-relationship as measured by g-ratio in the optic radiations (OR) in people with MS (pwMS) with and without previous optic neuritis (ON) compared to healthy controls (HC). Methods Thirty pwMS and 17 HCs were scanned on a 3Tesla Connectom scanner. AVF and MVF, derived from a multi-shell diffusion protocol and macromolecular tissue volume, respectively, were measured in normal-appearing white matter (NAWM) and lesions within the OR and used to calculate imaging g-ratio. Results OR AVF and MVF were decreased in pwMS compared to HC, and in OR lesions compared to NAWM, whereas the g-ratio was not different. Compared to pwMS with previous ON, AVF and g-ratio tended to be higher in pwMS without prior ON. AVF and MVF, particularly in NAWM, were positively correlated with retinal thickness, which was more pronounced in pwMS with prior ON. Conclusion Axonal measures reflect microstructural tissue damage in the OR, particularly in the setting of remote ON, and correlate with established metrics of visual health in MS.
Differentials in the Prevalence of Acute Respiratory Infections Among Under-Five Children: An Analysis of 37 Sub-Saharan Countries
Authors: Ekholuenetale Michael , Nzoputam Chimezie Igwegbe , Okonji Osaretin Christabel , Barrow Amadou , Wegbom Anthony Ike , Edet Clement Kevin 
Published: February 2023

Objective We investigated the prevalence and risk factors of ARI in children under 5 years old in 37 SSA countries. Methods Data from Demographic and Health Survey (DHS) of 37 African countries was examined in this analysis. Data from children under the age of 5 years old were examined. Forest plot was used to identify disparities in the occurrence of ARIs across SSA countries. Results We observed a higher prevalence of ARI among children under 5 in Uganda, Kenya, Sao Tome and Principe (9% each), Gabon, Chad, Eswatini (8% each), Burundi, Ethiopia, Congo Democratic Republic (7.0% each). The prevalence of ARI among under-five children who sought medical advice/treatment from health facility was higher in South Africa (88%), Sierra Leone (86%), Tanzanian (85%), Guinea (83%) and Uganda (80%). The prevalence rate of ARI among under-five children who received antibiotics was higher in Tanzania (61%), Sao Tome and Principe (60%), Rwanda and Congo (58% each), Angola (56.0%), Mozambique (54.0%), Kenya (53.0%), Namibia (52.0%) and Gabon (50.0%). This study found that the household wealth index, maternal education, and urban residence were significantly associated with ARI (p <0.001). A higher prevalence of ARI was observed among urban residents, low income families, and those with mothers with lower education. Conclusion ARI prevalence could be reduced by improving household socioeconomic status, child nutrition and community awareness of indoor and outdoor pollution. Interventions and programs focused on early diagnosis, treatment and prevention of ARIs are crucial in reducing ARIs particularly in developing countries.
Knowledge, Attitude, and Practice of Nurses Toward the Initial Managements of Acute Poisoning in Public Hospitals of Bahir Dar City, Northwest Ethiopia 2022: Cross-Sectional Study
Authors: Adal Ousman , Hiamanot Yigremew , Zakir Abdulkadir , Regassa Redeat , Gashaw Asnake 
Published: February 2023

Introduction Poisoning is a common cause of medical visits and hospitalizations around the world. The knowledge, attitude, and practice of nurses in the management of acute poisoning are very poor in developing countries, such as Ethiopia. According to the previous study, 75% and 45% of nurses had unsatisfactory knowledge and practice, respectively. Objectives This study aimed to assess the knowledge, attitude, and practice of nurses toward the initial management of acute poisoning. Method An institution-based cross-sectional study design was used to recruit 422 nurses from public hospitals of Bahir Dar city in Ethiopia. A systematic random sampling method and an English version of self-administered questionnaires were used to collect the data. The data were entered into Epi Data and analyzed using SPSS version 25. Results The study recruited 422 nurses, with a response rate of 100%; 248 (58.8%) and 264 (62.2%) of the nurses had good knowledge and practice, respectively. Slightly more than half (57.6%) of the nurses had a positive attitude. Nurses who worked in an emergency and intensive care unit had twice the odds of having more knowledge and practice than those who worked in an outpatient department (AOR = 2.1, CI: (1.019, 4.540), p = 0.001). Nurses who have MSc degree were twice (AOR = 2.1, CI: (1.019, 4.540), p = 0.001) and three times (AOR = 3.1, CI: (1.012, 7.140), p = 0.002) to have good knowledge and practice than those who have a diploma. Conclusion Slightly more than half of nurses had good knowledge, practice, and a positive attitude. Educational status, working in an emergency department, and having training in poison management have been significantly associated with the knowledge and practice of nurses. The authors recommended that there is a need to empower the attitude, knowledge, and practice of nurses through consistent training, accessing, and updating guidelines (poisoning management protocol). The author also suggested that the poison management protocol be incorporated into the Ethiopian nursing curriculum (certificates).