bluuebunny/crossref_metadata_2025_split huggingface dataset:
Invasive Group A streptococcal infections: are we facing a new outbreak? A case series with the experience of a single tertiary center
Authors: Garancini Nicolò , Ricci Giulia , Ghezzi Michele , Tommasi Paola , Zunica Fiammetta , Mandelli Anna , Zoia Elena , D’Auria Enza , Zuccotti Gian Vincenzo 
Published: July 2023

Abstract
Background
In pediatric age, Group A Streptococcus (GAS) is responsible for a wide spectrum of clinical manifestations, from mild localized infections to life-threatening invasive diseases. In December 2022, the World Health Organization reported an increased incidence of scarlet fever and invasive GAS infections (iGAS) cases in Europe and the United States. In line with these observations, surveillance has been strengthened in our Region, allowing the identification of certified or highly suspected forms of iGAS.

Case presentation
We report here 4 emblematic cases of iGAS admitted to our Intensive Care Unit (ICU) in the short time span from mid-February to mid-March 2023. Particularly, we describe a case of pleuropneumonia (4 year old boy) and a case of respiratory failure (2 year old boy), who necessitated Non-Invasive Ventilation support, a case of Streptococcal Toxic Shock Syndrome (6 year old girl), presenting with multi-organ failure, who needed Invasive Ventilation, and a case of meningitis (5 year old girl). All these patients needed intensive care support.

Conclusions
Accurate differential diagnosis and early treatment both could help to reduce the transmission of GAS and consequently the risk of severe iGAS. These cases confirmed the need for close monitoring and appropriate notification, in order to verify their actual increased incidence.
Neighborhood socioeconomic deprivation, healthcare access, and 30-day mortality and readmission after sepsis or critical illness: findings from a nationwide study
Authors: Lusk Jay B. , Blass Beau , Mahoney Hannah , Hoffman Molly N. , Clark Amy G. , Bae Jonathan , Ashana Deepshikha C. , Cox Christopher E. , Hammill Bradley G. 
Published: July 2023

Abstract
Background
To determine if neighborhood socioeconomic deprivation independently predicts 30-day mortality and readmission for patients with sepsis or critical illness after adjusting for individual poverty, demographics, comorbidity burden, access to healthcare, and characteristics of treating healthcare facilities.

Methods
We performed a nationwide study of United States Medicare beneficiaries from 2017 to 2019. We identified hospitalized patients with severe sepsis and patients requiring prolonged mechanical ventilation, tracheostomy, or extracorporeal membrane oxygenation (ECMO) through Diagnosis Related Groups (DRGs). We estimated the association between neighborhood socioeconomic deprivation, measured by the Area Deprivation Index (ADI), and 30-day mortality and unplanned readmission using logistic regression models with restricted cubic splines. We sequentially adjusted for demographics, individual poverty, and medical comorbidities, access to healthcare services; and characteristics of treating healthcare facilities.

Results
A total of 1,526,405 admissions were included in the mortality analysis and 1,354,548 were included in the readmission analysis. After full adjustment, 30-day mortality for patients was higher for those from most-deprived neighborhoods (ADI 100) compared to least deprived neighborhoods (ADI 1) for patients with severe sepsis (OR 1.35 95% [CI 1.29–1.42]) or with prolonged mechanical ventilation with or without sepsis (OR 1.42 [95% CI 1.31, 1.54]). This association was linear and dose dependent. However, neighborhood socioeconomic deprivation was not associated with 30-day unplanned readmission for patients with severe sepsis and was inversely associated with readmission for patients requiring prolonged mechanical ventilation with or without sepsis.

Conclusions
A strong association between neighborhood socioeconomic deprivation and 30-day mortality for critically ill patients is not explained by differences in individual poverty, demographics, measured baseline medical risk, access to healthcare resources, or characteristics of treating hospitals.
Radiomics-based fertility-sparing treatment in endometrial carcinoma: a review
Authors: Wang Yuanjian , Chen Zhongshao , Liu Chang , Chu Ran , Li Xiao , Li Mingbao , Yu Dexin , Qiao Xu , Kong Beihua , Song Kun 
Published: July 2023

AbstractIn recent years, with the increasing incidence of endometrial carcinoma in women of child-bearing age, to decision of whether to preserve patients’ fertility during treatment has become increasingly complex, presenting a formidable challenge for both physicians and patients. Non-fertility-sparing treatment can remove lesions more thoroughly than fertility-sparing treatment. However, patients will permanently lose their fertility. In contrast, fertility-sparing treatment can treat tumors without impairing fertility, but the risk of disease progression is high as compared with non-fertility-sparing treatment. Therefore, it is extremely important to accurately identify patients who are suitable for fertility-sparing treatments. The evaluation of prognostic factors, including myometrial invasion, the presence of lymph node metastases, and histopathological type, is vital for determining whether a patient can receive fertility-sparing treatment. As a non-invasive and quantitative approach, radiomics has the potential to assist radiologists and other clinicians in determining more precise judgments with regard to the above factors by extracting imaging features and establishing predictive models. In this review, we summarized currently available fertility-sparing strategies and reviewed the performance of radiomics in predicting risk factors associated with fertility-sparing treatment. This review aims to assist clinicians in identifying patients suitable for fertility-sparing treatment more accurately and comprehensively and informs more appropriate and rigorous treatment decisions for endometrial cancer patients of child-bearing age.Critical relevance statement: Radiomics is a promising tool that may assist clinicians identify risk factors about fertility-sparing more accurately and comprehensively.
Graphical abstract
The mutational landscape of a US Midwestern breast cancer cohort reveals subtype-specific cancer drivers and prognostic markers
Authors: Vellichirammal Neetha Nanoth , Tan Yuan-De , Xiao Peng , Eudy James , Shats Oleg , Kelly David , Desler Michelle , Cowan Kenneth , Guda Chittibabu 
Published: July 2023

Abstract
Background
Female breast cancer remains the second leading cause of cancer-related death in the USA. The heterogeneity in the tumor morphology across the cohort and within patients can lead to unpredictable therapy resistance, metastasis, and clinical outcome. Hence, supplementing classic pathological markers with intrinsic tumor molecular markers can help identify novel molecular subtypes and the discovery of actionable biomarkers.

Methods
We conducted a large multi-institutional genomic analysis of paired normal and tumor samples from breast cancer patients to profile the complex genomic architecture of breast tumors. Long-term patient follow-up, therapeutic regimens, and treatment response for this cohort are documented using the Breast Cancer Collaborative Registry. The majority of the patients in this study were at tumor stage 1 (51.4%) and stage 2 (36.3%) at the time of diagnosis. Whole-exome sequencing data from 554 patients were used for mutational profiling and identifying cancer drivers.

Results
We identified 54 tumors having at least 1000 mutations and 185 tumors with less than 100 mutations. Tumor mutational burden varied across the classified subtypes, and the top ten mutated genes include MUC4, MUC16, PIK3CA, TTN, TP53, NBPF10, NBPF1, CDC27, AHNAK2, and MUC2. Patients were classified based on seven biological and tumor-specific parameters, including grade, stage, hormone receptor status, histological subtype, Ki67 expression, lymph node status, race, and mutational profiles compared across different subtypes. Mutual exclusion of mutations in PIK3CA and TP53 was pronounced across different tumor grades. Cancer drivers specific to each subtype include TP53, PIK3CA, CDC27, CDH1, STK39, CBFB, MAP3K1, and GATA3, and mutations associated with patient survival were identified in our cohort.

Conclusions
This extensive study has revealed tumor burden, driver genes, co-occurrence, mutual exclusivity, and survival effects of mutations on a US Midwestern breast cancer cohort, paving the way for developing personalized therapeutic strategies.
Higher Myonuclei Density in Muscle Fibers Persists Among Former Users of Anabolic Androgenic Steroids
Authors: Nielsen Jakob Lindberg , Rasmussen Jon Jarløv , Frandsen Mikkel Nicklas , Fredberg Jeppe , Brandt-Jacobsen Niels Høegh , Aagaard Per , Kistorp Caroline 
Published: July 2023

Abstract

Context
No information exists on the long-lasting effects of supraphysiological anabolic androgenic steroids (AASs) usage on the myocellular properties of human skeletal muscle in previous AAS users.

Objective
We hypothesized that former AAS users would demonstrate smaller myonuclei domains (ie, higher myonuclei density) than matched controls.

Methods
A community-based cross-sectional study in men aged 18-50 years engaged in recreational strength training. Muscle biopsies were obtained from the m. vastus lateralis. Immunofluorescence analyses were performed to quantify myonuclei density and myofiber size.

Results
Twenty-five males were included: 8 current and 7 previous AAS users and 10 controls. Median (25th-75th percentiles) accumulated duration of AAS use was 174 (101-206) and 140 (24-260) weeks in current and former AAS users, respectively (P = .482). Geometric mean (95% CI) elapsed duration since AAS cessation was 4.0 (1.2; 12.7) years among former AAS users. Type II muscle fibers in former AAS users displayed higher myonuclei density and DNA to cytoplasm ratio than controls, corresponding to smaller myonuclei domains (P = .013). Longer accumulated AAS use (weeks, log2) was associated with smaller myonuclei domains in previous AAS users: beta-coefficient (95% CI) −94 (−169; −18), P = .024. Type I fibers in current AAS users exhibited a higher amount of satellite cells per myofiber (P = .031) than controls.

Conclusion
Muscle fibers in former AAS users demonstrated persistently higher myonuclei density and DNA to cytoplasm ratio 4 years after AAS cessation suggestive of enhanced retraining capacity.
Quantitative ethnobotany of medicinal plants used by the Bodo Community of Baksa District, BTR, Assam, India
Authors: BORO MIJING , DAS BARNALI , BORO KRISHNA KUMAR , NATH MADHUSHMITA , BURAGOHAIN PRIYAKSHI , ROY SHILPA , SARMA PARAG JYOTI , KALITA SUSHMITA , NATH NAMITA 
Published: July 2023

Abstract. Boro M, Das B, Boro KK, Nath M, Buragohain P, Roy S, Sarma PJ, Kalita S, Nath M. 2023. Quantitative ethnobotany of medicinal plants used by the Bodo Community of Baksa District, Assam, India. Biodiversitas 24: 3169-3182. Plants are the core part of religious and cultural aspects of various ethnic communities of the world. Assam is a homeland of diverse ethnic tribes of Indo-Mongolian origin. The Bodo Community is one of the oldest communities and they are rich in their traditional healthcare knowledge system. The current study aimed to record the data on medicinal plants used by the Bodo Community in Baksa District, Assam, India. Statistical analysis was done by following established formula to find Use Value (UV), Relative Frequency of Citation (RFC), Informant Agreement Ration (IAR) and Informant Consensus (Fic). A total of 129 medicinal plant species were recorded, used in 18 different ailment categories by the Bodo people. Kalanchoe pinnata (Lam.) Pers. was the most used plant by the informants (use value 0.69) and also had the highest RFC (0.60). In present survey, the IAR range was from 0-1. The highest Fic value was recorded in the ailment category of Renal and hepatic disorder. The present work provides rich data, as this work, besides documenting the medicinal plants used by the community, also gives proper scientific evaluation of the ethnobotanical data. The work will be helpful for future researchers, academicians and stakeholders to carry out research work in this diverse scientific field of ethnobotany. From the conservation point of view, there is an urgent need to involve local people for the conservation of medicinal plants for the future.
Kajian Teoritik Persamaan Diferensial Stokastik bagi Kurs Mata Uang (Forex), Kajian Khusus : Kurs IDR/USD
Authors: Isnawanti Isa , Palupi Dwi Satya 
Published: July 2023

<p>Telah dilakukan kajian persamaan diferensial stokastik bagi pergerakan kurs mata uang. Kajian terhadap rapat peluang return perlu dilakukan karena rapat peluang return menggambarkan fluktuasi kurs mata uang serta mencerminkan interaksi yang terjadi di pasar keuangan. Pada penelitian ini return kurs mata uang diasumsikan mengikuti proses stokastik yang dapat digambarkan oleh suatu persamaan diferensial stokastik, sehingga distribusi rapat peluang return dapat digambarkan oleh persamaan Fokker-Planck. Data yang digunakan pada penelitian ini adalah kurs mata uang IDR/USD dari Januari 2001 sampai Januari 2021 yang diperoleh dari data kurs transaksi Bank Sentral Republik Indonesia. Distribusi rapat peluang return harian yang diperoleh mengikuti distribusi Gaussian dengan rata-rata −0, 0001 dan sigma = 0, 0048. Berdasarkan distribusi tersebut dapat dibentuk persamaan diferensial stokastik bagi return kurs mata uang IDR/USD.</p>
The clinical characteristics and related factors of centrally mediated abdominal pain syndrome
Authors: Yuming Tang , Jiani Song , Hefeng Chen , Ying Zhu , Weiyan Yao , Duowu Zou 
Published: July 2023

Abstract

Objective:
To explore the clinical characteristics and related factors of centrally mediated abdominal pain syndrome (CAPS).

Methods:
Our study included 73 CAPS patients and 132 age- and gender-matched healthy controls. The general information of the participants was collected and the questionnaires were completed including 7-item Generalized Anxiety Disorder scale, the 9-item Patient Health Questionnaire, the Hamilton Anxiety Scale, the Hamilton Depression Scale Pittsburgh sleep quality index, visual analogue scale and Short Form 36. Univariate and forward stepwise regression analysis was performed to explore the influencing factors of centrally mediated abdominal pain syndrome.

Results:
Non-exercise, mild to moderate depression, married status and drinking coffee (AOR=4.53 CI (1.602∼12.809); AOR=7.931 CI(3.236∼19.438); AOR=3.656 CI(1.317∼10.418); AOR=0.199 CI(0.051∼0.775) ) were found to be related with centrally mediated abdominal syndrome. The Hamilton Anxiety Scale score (7-13) was significantly related to moderate to severe abdominal pain (AOR=7.043 CI(1.319∼37.593)) . Higher Hamilton Depression Scale score was related to lower mental component scale score (β=-0.726, p<0.01 ) and physical component scale score (β=-0.706, p<0.01).

Conclusion:
Depression, married status and non-exercise were the independent risk factors of centrally mediated abdominal pain syndrome. Conversely, coffee intake was an independent protective factor of centrally mediated abdominal pain syndrome. Anxiety was related to the severity of abdominal pain, while depression was related to low health-related quality of life.
“Shut up! Don’t say that! You’ve got to say ḤASHĀKEM!” The pragmatics of Ḥashāk and its variants in colloquial Algerian Arabic
Authors: Dendenne Boudjemaa 
Published: July 2023

Abstract
In this paper, the pragmatic functions served by ḥāshāk and its variants in colloquial Algerian Arabic (CAA) are unravelled. Literally, ḥāshāk means “You’re exalted/exempt from X/I distance you from X,” where X is a bad thing or socially/religiously unacceptable act. Its variants include ḥāsha, ḥāshākem, ḥāshāh/ḥāshāha/ḥāshāhem, maḥashākesh, and the verb ḥāsha/ḥāshi. As far as the author is aware, this is the first study on the pragmatics of ḥāshāk and its variants in colloquial (Algerian) Arabic. Two complementary data sets were collected and analyzed: an online survey administered to native speakers (N= 263) and a corpus of naturally occurring examples gained using an ethnographic method (N= 172). The findings indicated that the core semantic import (exaltative/excepting/exempting meaning) is retained in CAA and further extended to perform other pragmatic functions: apologetic, appreciative, requestive, concessive, critical, defensive, and sarcastic. These intertwined functions are expected in an array of highly conventionalized contexts. These findings were discussed from an eclectic perspective (e.g., pragmatic reversal, pragmatic markers, politeness theory, and rapport management).
Intelligent computing for the double-diffusive peristaltic rheology of magneto couple stress nanomaterials
Authors: Shoaib Muhammad , Ali Faizan , Awais Muhammad , Naz Iqra , Shamim Robicca , Nisar Kottakkaran Sooppy , Raja Muhammad Asif Zahoor , Malik Muhammad Yousaf , Abbas Mohamed , Saleel C. Ahamed 
Published: July 2023

Abstract
In nanofluids, the effect of convection in the presence of double diffusivity on a magneto couple stress fluid with the peristaltic flow of a model in a non-uniform channel (MCSFM) is reviewed in this article. This research discusses MCSF in a non-uniform channel by applying the Levenberg–Marquardt procedure via an artificial backpropagated neural network (LMP-ABNN). For two-dimensional and two-directional flows, mathematical formulations of double-diffusivity convection of a magneto couple stress fluid in nanofluids are developed. The partial differential equations are reduced to ordinary differential equations by using appropriate transformations. The assessment of the Hartmann number, thermophoresis parameter, Dufour parameter, Soret parameter, and magnetic Reynolds number over concentration profiles and temperature profiles is made by generating a dataset for LMP-ABNN based on the ND solve method for different variations of MSCFM. To examine the approximate solution validation, training and testing procedures are interpreted, and the performance is verified through error histogram and mean square error results. The extremely nonlinear equations are reduced by employing a long-wavelength approximation and a low but finite Reynolds number. To describe the behavior of flow quantities, graphical representations of a variety of physical characteristics of importance are shown. The impact of the Hartmann number and magnetic Reynolds number over axial magnetic field and current density is also studied. The concentration increases as the thermophoresis parameter and Dufour parameter values increase. This occurs because the concentration and both these parameters have a direct relationship. We observed opposite behavior for both the magnetic Reynolds number and the Hartman number. The behavior of current density J

z
increases with increasing values of R
m. Both the temperature distribution and solute concentration increase. The final outcome of this study is to provide the potential for these techniques to provide new insights and solutions to challenging problems in nanofluids and other areas of fluid mechanics and to facilitate the design of more efficient and effective microfluidic devices.
Motorways of Prehistory? Boats, Rivers and Moving in Mesolithic Ireland
Authors: Moucheron Martin 
Published: July 2023

Abstract
This article presents a critical review of the way inland navigation is constructed in the archaeological literature as an essential component of mobility in Mesolithic Ireland, with a particular focus on boats and rivers. Against a scarce background of direct archaeological and environmental evidence, a content analysis of the academic discourse highlights a dominant processual approach structured around three themes: seafaring and pioneering “events”; boat technology and performance; broad generalisations about the land- and waterscape. It is argued that such a narrative could be usefully revisited by adopting a small-scale, high-resolution approach that would explore human and material agency and integrate analogy as a method.
First Archaeological Record of the Torture and Mutilation of Indigenous Mapuche During the “War of Arauco,” Sixteenth Century
Authors: Sánchez Juan Francisco Reyes , Pérez Alberto Enrique 
Published: July 2023

Abstract
Newen Antug is a multicomponent (residential and funerary) archaeological site located in the Lácar basin south of Neuquén, Argentina, in the east Andean section of the binational basin of the Valdivia River. Two human skeletons were discovered during the excavation of the site. Based on radiocarbon dating and associated material contexts, the burials can be associated with the period of first contact between the indigenous people of the region with the Spanish. Based on the analysis of historical sources, bioanthropological studies, and forensic data, we postulate that these individuals were tortured victims of the war waged by the Spaniards against the indigenous inhabitants. The skeletal remains present various perimortem trauma. The left hand and distal end of the left forearm was absented in situ and which are discussed as being possible form of mutilations of the upper limbs. Individual 1♀ had a horse (Equus caballus) leg replacing or symbolising the missing left limb. The mutilation practice is recorded as part of the power devices characteristic of the Warfare Phase (1536–1655) of the conquest, when the Spanish were attempting to establish a pre-disciplinary machinery of their “Sovereign Power” in the south-central Chile. The findings reported here extend this process to Northeastern Patagonia in Argentina.
Multichannel bridges and NSC synergize to enhance axon regeneration, myelination, synaptic reconnection, and recovery after SCI
Authors: Nekanti Usha , Sakthivel Pooja , Zahedi Atena , Creasman Dana , Nishi Rebecca , Dumont Courtney , Piltti Katja , Guardamondo Glenn , Hernandez Norbert , Chen Xingyuan , Song Hui , Lin Xiaoxiao , Martinez Joshua , On Lillian , Lakatos Anita , Pawar Kiran , David Brian , Guo Zhiling , Seidlits Stephanie , Xu Xiangmin , Shea Lonnie , Cummings Brian , Anderson Aileen 
Published: July 2023

Abstract
Regeneration in the injured spinal cord is limited by physical and chemical barriers. Acute implantation of a multichannel poly(lactide-co-glycolide) (PLG) bridge mechanically stabilizes the injury, modulates inflammation, and provides a permissive environment for rapid cellularization and robust axonal regrowth through this otherwise inhibitory milieu. However, without additional intervention, regenerated axons remain largely unmyelinated (<10%), limiting functional repair. While transplanted human neural stem cells (hNSC) myelinate axons after spinal cord injury (SCI), hNSC fate is highly influenced by the SCI inflammatory microenvironment, also limiting functional repair. Accordingly, we investigated the combination of PLG scaffold bridges with hNSC to improve histological and functional outcome after SCI. In vitro, hNSC culture on a PLG scaffold increased oligodendroglial lineage selection after inflammatory challenge. In vivo, acute PLG bridge implantation followed by chronic hNSC transplantation demonstrated a robust capacity of donor human cells to migrate into PLG bridge channels along regenerating axons and integrate into the host spinal cord as myelinating oligodendrocytes and synaptically integrated neurons. Axons that regenerated through the PLG bridge formed synaptic circuits that connected ipsilateral forelimb muscle to contralateral motor cortex. hNSC transplantation significantly enhanced the total number of regenerating and myelinated axons identified within the PLG bridge. Finally, the combination of acute bridge implantation and hNSC transplantation exhibited robust improvement in locomotor recovery vs. control and hNSC transplant alone. These data identify a successful novel strategy to enhance neurorepair through a temporally layered approach using acute bridge implantation and chronic cell transplantation to spare tissue, promote regeneration, and maximize the function of new axonal connections.