bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exact QFT duals of AdS black holes
Authors: Choi Sunjin , Jeong Saebyeok , Kim Seok , Lee Eunwoo 
Published: September 2023

Abstract
We construct large N saddle points of the matrix model for the $$ \mathcal{N} $$
N
= 4 Yang- Mills index dual to the BPS black holes in AdS5 × S5, in two different setups. When the two complex chemical potentials for the angular momenta are collinear, we find linear eigenvalue distributions which solve the large N saddle point equation. When the chemical potentials are not collinear, we find novel solutions given by areal eigenvalue distributions after slightly reformulating the saddle point problem. We also construct a class of multi-cut saddle points, showing that they sometimes admit nontrivial filling fractions. As a byproduct, we find that the Bethe ansatz equation emerges from our saddle point equation.
Equivariant pliability of the projective space
Authors: Cheltsov Ivan , Sarikyan Arman 
Published: September 2023

AbstractWe classify finite subgroups $$G\subset {\textrm{PGL}}_4({\mathbb {C}})$$

G
⊂

PGL
4

(
C
)

such that $${\mathbb {P}}^3$$

P

3

is not G-birational to conic bundles and del Pezzo fibrations, and explicitly describe all G-Mori fibre spaces that are G-birational to $${\mathbb {P}}^3$$

P

3

for these subgroups.
Addison-Krise im Rahmen eines autoimmunen, polyglandulären Syndroms Typ 2
Authors: Manske J. , Pohle R. , Mirza J. , Weiß M. , Boemers T. M. 
Published: September 2023

ZusammenfassungEine 16-jährige Patientin stellt sich 14 Tage nach einer Appendektomie in der kinderchirurgischen Ambulanz mit Bauchschmerzen, einer lokalen Wundinfektion, Fieber und Erbrechen vor. Nach einer Wiedervorstellung in derselben Nacht erfolgt die stationäre Aufnahme aufgrund einer Exsikkose und stark reduziertem Allgemeinzustand. Wegen einer arteriellen Hypotonie und Tachykardie, trotz Infusionstherapie, wird die Patientin mit dem V. a. eine Sepsis auf die Intensivstation verlegt. Trotz Eskalation der antibiotischen Therapie bleibt eine Besserung ihres Zustands aus, daher wird aufgrund einer therapieresistenten Hypotonie und einer auffälligen Hyperpigmentation der Verdacht auf eine Addison-Krise gestellt. Nach Gabe von Hydrokortison stellt sich eine rasche Verbesserung der klinischen Symptomatik ein. Die Hormon- und Autoantikörperdiagnostik bestätigt den Verdacht eines M. Addison. In Kombination mit der noch frisch diagnostizierten Hashimoto-Thyreoiditis liegt ein autoimmunes polyglanduläres Syndrom (APS) vom Typ 2 vor.
Combined anterior cruciate ligament revision with reconstruction of the antero‐lateral ligament does not improve outcome at 2‐year follow‐up compared to isolated acl revision; a randomized controlled trial
Authors: Sørensen Ole Gade , Faunø Peter , Konradsen Lars , Nielsen Torsten , Schaarup Susanne , Mygind‐Klavsen Bjarne , Krogsgaard Michael , Lind Martin 
Published: September 2023

AbstractPurposeIt is essential to obtain rotational stability of the knee after anterior cruciate ligament reconstruction (ACL‐R) and it is suggested that a supplementary reconstruction of the antero‐lateral ligament (ALL‐R) may supports this. Theoretically, ALL‐R may be particularly advantageous to support revision of failed ACL‐Rs. It was hypothesized that ACL revision combined with ALL‐R will result in superior outcome compared to isolated ACL revision.MethodsThe study was designed as a randomized controlled trial. Patients eligible for first time ACL revision were randomized to either isolated ACL revision (− ALL group) or ACL revision combined with a single‐stranded allograft ALL‐reconstruction (+ ALL group). Patient reported outcomes and function were evaluated at two‐year follow‐up by KNEES‐ACL, KOOS, and Tegner activity scale. Objective knee laxity was evaluated at one‐year follow‐up using an instrumented Rolimeter test, the pivot shift test, and a manual Lachman test.ResultsA total of 103 patients were enrolled with 49 patients randomized to the + ALL group and 54 patients in the − ALL group. There were no differences at baseline between groups regarding age, gender, body mass index, preoperative patient reported outcome scores and concomitant meniscus or cartilage injury. The ACL revision was performed with an allograft in 10 patients (20%) in the + ALL group and 8 patients (15%) in the ‐ALL group. At follow‐up there was no significant difference between the groups in patient reported outcome scores and clinical knee laxity.ConclusionSupplementary ALL‐R does not improve subjective outcome of first time ACL revision at two‐years and clinical knee stability at one‐year follow‐up compared to isolated ACL revision.Level of evidenceLevel I.
Tailoring microbial response to stainless steel surfaces via electrolyte jet machining and electrodeposition
Authors: Lutey Adrian H. A. , Romoli Luca , Lee Janggeon , Kunieda Masanori 
Published: September 2023

AbstractElectrolyte jet machining (EJM) and electrodeposition present unexploited opportunities for the manufacturing of multiscale structured surfaces. The present work assesses the morphology and antibacterial properties of textured and multiscale stainless steel surfaces produced by EJM with a new 50 mm × 0.3 mm slit nozzle, as well as multiscale surfaces subject to electrodeposition with copper. Characterisation of the surface morphology obtained via EJM with various combinations of current density, machining time and groove spacing is performed to facilitate the selection of representative surfaces for bacterial retention tests. Higher current density with constant applied charge leads to lower surface roughness at constant scanning speed and greater groove depth and width under static conditions. Groove depth is proportional to machining time at constant current density, while a groove pitch of 1.05 mm is found to provide the optimum compromise between maximum groove depth and complete surface coverage. Microscale surface features are found to reduce Escherichia coli and Pseudomonas aeruginosa retention by up to 97% compared to untextured control surfaces, while larger grooves play a role in inhibiting bacterial attachment by inducing turbulence. The presence of copper agglomerates completely eliminates bacterial retention under the tested conditions. The developed process provides a flexible approach to tailoring surface properties for specific applications requiring antimicrobial properties.
Extended duration of treatment using reduced-frequency dosing of anti-PD-1 therapy in patients with advanced melanoma and Merkel cell carcinoma
Authors: Tachiki Lisa May Ling , Hippe Daniel S. , Williams Silva Karly , Hall Evan Thomas , McCamy William , Fritzsche Dane , Perdue Andrea , Majovski Julia , Pulliam Thomas , Goldstein Daniel A. , Veatch Joshua , Ho Joel , Nghiem Paul T. , Thompson John A. , Bhatia Shailender 
Published: September 2023

Abstract
Background
Optimal duration of treatment (DoT) with immune checkpoint inhibitors (ICI) in metastatic cancers remains unclear. Many patients, especially those without radiologic complete remission, develop progressive disease after ICI discontinuation. Extending DoT with ICI may potentially improve efficacy outcomes but presents major logistical and cost challenges with standard frequency dosing (SFD). Receptor occupancy data supports reduced frequency dosing (RFD) of anti-PD-1 antibodies, which may represent a more practical and economically viable option to extend DoT.

Methods
We conducted a retrospective study of patients with metastatic melanoma and Merkel cell carcinoma (MCC), who received ICI at RFD administered every 3 months, after initial disease control at SFD. We evaluated efficacy, safety, and cost-savings of the RFD approach in this cohort.

Results
Between 2014 and 2021, 23 patients with advanced melanoma (N = 18) or MCC (N = 5) received anti-PD-1 therapy at RFD. Median DoT was 1.1 years at SFD and 1.2 years at RFD. The 3 year PFS after start of RFD was 73% in melanoma and 100% in MCC patients, which compare favorably to historical control rates. In the subset of 15 patients who received at least 2 years of therapy, total savings amounted to $1.1 million in drug costs and 384 h saved despite the extended DoT (median 3.4 years), as compared to the calculated cost of 2 years at SFD.

Conclusions
ICI administration at RFD can allow extension of treatment duration, while preserving efficacy and reducing logistical and financial burden. RFD approach deserves further exploration in prospective clinical trials.
Reproducibility of radiomics quality score: an intra- and inter-rater reliability study
Authors: Akinci D’Antonoli Tugba , Cavallo Armando Ugo , Vernuccio Federica , Stanzione Arnaldo , Klontzas Michail E. , Cannella Roberto , Ugga Lorenzo , Baran Agah , Fanni Salvatore Claudio , Petrash Ekaterina , Ambrosini Ilaria , Cappellini Luca Alessandro , van Ooijen Peter , Kotter Elmar , Pinto dos Santos Daniel , Cuocolo Renato ,   for the EuSoMII Radiomics Auditing Group
Published: September 2023

Abstract
Objectives
To investigate the intra- and inter-rater reliability of the total radiomics quality score (RQS) and the reproducibility of individual RQS items’ score in a large multireader study.

Methods
Nine raters with different backgrounds were randomly assigned to three groups based on their proficiency with RQS utilization: Groups 1 and 2 represented the inter-rater reliability groups with or without prior training in RQS, respectively; group 3 represented the intra-rater reliability group. Thirty-three original research papers on radiomics were evaluated by raters of groups 1 and 2. Of the 33 papers, 17 were evaluated twice with an interval of 1 month by raters of group 3. Intraclass coefficient (ICC) for continuous variables, and Fleiss’ and Cohen’s kappa (k) statistics for categorical variables were used.

Results
The inter-rater reliability was poor to moderate for total RQS (ICC 0.30–055, p < 0.001) and very low to good for item’s reproducibility (k − 0.12 to 0.75) within groups 1 and 2 for both inexperienced and experienced raters. The intra-rater reliability for total RQS was moderate for the less experienced rater (ICC 0.522, p = 0.009), whereas experienced raters showed excellent intra-rater reliability (ICC 0.91–0.99, p < 0.001) between the first and second read. Intra-rater reliability on RQS items’ score reproducibility was higher and most of the items had moderate to good intra-rater reliability (k − 0.40 to 1).

Conclusions
Reproducibility of the total RQS and the score of individual RQS items is low. There is a need for a robust and reproducible assessment method to assess the quality of radiomics research.

Clinical relevance statement
There is a need for reproducible scoring systems to improve quality of radiomics research and consecutively close the translational gap between research and clinical implementation.

Key Points
• Radiomics quality score has been widely used for the evaluation of radiomics studies.
• Although the intra-rater reliability was moderate to excellent, intra- and inter-rater reliability of total score and point-by-point scores were low with radiomics quality score.
• A robust, easy-to-use scoring system is needed for the evaluation of radiomics research.
Assessment of the level III of Inoue by preoperative endoscopic ultrasound and elastography: a novel approach to predict a periarterial divestment technique in borderline resectable (BR) or locally advanced (LA) pancreatic adenocarcinoma—How I do it
Authors: Alberti Piero , Pando Elizabeth , Abu-Suboh Monder , Masachs Miquel , Merino Xavier , Salcedo Maite , Macarulla Teresa , Balsells Joaquin , Charco Ramon 
Published: September 2023

Abstract
Background
Periarterial divestment is a surgical technique to approach borderline resectable (BR) or locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC) with arterial involvement. There are no reports in the literature regarding the role of endoscopic ultrasound and elastography (EUS-EG) in exploring the integrity of Inoue’s level III and its correlation with the periarterial divestment technique feasibility. Our research is aimed at exploring the role of EUS-EG in this scenario.

Methods
We describe our approach to Inoue’s level II by EUS-EG in patients with BR and LA pancreatic cancer patients after neoadjuvant chemotherapy.

Results
Between June 2019 and December 2020, four patients out of 25 were eligible to perform a preoperative EUS-EG. In all cases, Inoue’s level III integrity was corroborated by EUS-EG and confirmed posteriorly in the surgical scenario where a periarterial divestment technique was feasible. Vein resections were necessary in all cases, with no need for arterial resection. An R0 (> 1 mm) margin was achieved in all patients, and the histopathological assessment showed the presence of neurovascular tissue at the peripheral arterial margin.

Conclusion
Preoperatively, EUS-EG is a novel approach to explore the integrity of Inoue’s level III and could be helpful to preclude a periarterial divestment technique in borderline resectable or locally advanced pancreatic adenocarcinoma with arterial involvement.
Estimating cucumber crop coefficients under different greenhouse microclimatic conditions
Authors: Nikolaou Georgios , Neocleous Damianos , Kitta Evangelini , Katsoulas Nikolaos 
Published: September 2023

AbstractThis study aimed to determine cucumber crop coefficients under different greenhouse microclimatic conditions, parameterizing the Priestley-Taylor reference evapotranspiration model. Crop evapotranspiration was directly measured with the use of lysimeters, and crop coefficients were computed following the two-step climate FAO 56 methodology. Greenhouse compartments (i.e., cooled or uncooled) showed reference evapotranspiration differences of up to 12% in an autumn-winter crop. The results presented cucumber crop coefficient values from the initial to the late-season growth stages from 0.45 to 0.94 depending on the greenhouse climate. Based on the greenhouse hourly microclimatic variation of KC, it is recommended not to apply a KC as a constant for transpiration estimation even at greenhouses located within the same region Regression analysis relating crop coefficients with leaf area revealed very high correlation coefficients for the equations tested. The results indicated that evapotranspiration can be modeled satisfactory based on a significant relationship between crop coefficient and simple measurements of the leaf area index (i.e., KC = 0.447 × LAI).
Von Leitfunktionen, Nutzungsmischung, Krisen und Chancen
Authors: Ribbeck-Lampel Juliane , Weidner Silke 
Published: September 2023

ZusammenfassungMit der Covid-19-Pandemie und ihren massiven Einschränkungen ist die Innenstadtentwicklung nicht nur medial, sondern vor allem wirtschaftlich und gesellschaftspolitisch erneut in den Betrachtungsfokus gerückt. Positionspapiere, Streitgespräche und Debatten sowie Förderprogramme auf Bundes- und Landesebene oder auch die Gründung neuer Netzwerke und Beiräte sind nur einige der Aktivitäten, die in den vergangenen drei Jahren zur Stärkung der Innenstädte initiiert wurden. Dabei zeigt die langfristig angelegte Betrachtung, dass die in der aktuellen Situation gesetzten Innenstadtthemen von Leitfunktionen und Nutzungsmischung keine „Neuen“ sind.Der Fachbeitrag stellt in einem „Blitzlicht“ gegenüber, welche Themen die Ansätze zur Innenstadtentwicklung in den vergangenen 15 Jahren prägten. Er arbeitet Ansprüche und Haltungen zur Innenstadtentwicklung chronologisch auf und stellt die Themenzyklen der Innenstadtgestaltung und -steuerung übersichtsartig dar. Dazu werden vier strategische Dokumente aus dem Betrachtungszeitraum zwischen 2008 und 2021 in einer ersten Empiriephase ausgewählt, inhaltsanalytisch ausgewertet und ihre Schwerpunktsetzungen vergleichend gegenübergestellt.Diese Zusammenstellung zeigt, dass die Funktionen der Innenstadt im Sinne des Europäischen Raummodells wiederkehrend als Schlüssel thematisiert und verhandelt werden. Lange Linien, Sprünge und neue Ausrichtungen bzw. Interpretationen werden abhängig vom Zeitkontext sichtbar und verdeutlichen zugleich, dass nicht alles aktuell Diskutierte, und als innovativer Ansatz Proklamierte, in Gänze neu ist.
Multiscale modeling of lubrication flows under rarefied gas conditions
Authors: Tatsios Giorgos , Gibelli Livio , Lockerby Duncan A. , Borg Matthew K. 
Published: September 2023

AbstractWe present a multiscale method for simulating non-equilibrium lubrication flows. The effect of low pressure or tiny lubricating geometries that gives rise to rarefied gas effects means that standard Navier–Stokes solutions are invalid, while the large lateral size of the systems that need to be investigated is computationally prohibitive for Boltzmann solutions, such as the direct simulation Monte Carlo method (DSMC). The multiscale method we propose is applicable to time-varying, low-speed, rarefied gas flows in quasi-3D geometries that are now becoming important in various applications, such as next-generation microprocessor chip manufacturing, aerospace, sealing technologies and MEMS devices. Our multiscale simulation method provides accurate solutions, with errors of less than 1% compared to the DSMC benchmark results when all modeling conditions are met. It also shows computational gains over DSMC that increase when the lateral size of the systems increases, reaching 2–3 orders of magnitude even for relatively small systems, making it an effective tool for simulation-based design.
Relationship Between Anxiety Sensitivity and Post-Traumatic Stress Symptoms in Trauma-Exposed Children and Adolescents: A Meta-Analysis
Authors: Chiu Henry Tak Shing , Chan Angel Hiu Tung , Meiser-Stedman Richard 
Published: September 2023

Abstract
Introduction
Given the high rate of trauma exposure among children and adolescents, it is important to understand the risk factors for post-traumatic stress disorder (PTSD). Anxiety sensitivity has been implicated in multiple anxiety disorders, and an emerging evidence base has explored the relationship between this construct and PTSD. The present review investigated the size of the relationship between anxiety sensitivity and PTSD symptoms among children and adolescents exposed to trauma.

Method
A systematic search on multiple electronic databases (MEDLINE, PsycINFO, CINAHL and PTSDpubs) returned a total of 2916 records, among which six (n = 1331) met study inclusion criteria and were included in our random effects meta-analysis.

Results
Our results indicated a large effect size (r = .56, 95% CI = 0.47 − 0.64) for the relationship between anxiety sensitivity and PTSD symptoms; there was significant between-study heterogeneity.

Conclusion
This supported current cognitive models of anxiety and PTSD. Clinical implications, strengths and limitations of the review were discussed.
Developers talking about code quality
Authors: Börstler Jürgen , Bennin Kwabena E. , Hooshangi Sara , Jeuring Johan , Keuning Hieke , Kleiner Carsten , MacKellar Bonnie , Duran Rodrigo , Störrle Harald , Toll Daniel , van Assema Jelle 
Published: September 2023

AbstractThere are many aspects of code quality, some of which are difficult to capture or to measure. Despite the importance of software quality, there is a lack of commonly accepted measures or indicators for code quality that can be linked to quality attributes. We investigate software developers’ perceptions of source code quality and the practices they recommend to achieve these qualities. We analyze data from semi-structured interviews with 34 professional software developers, programming teachers and students from Europe and the U.S. For the interviews, participants were asked to bring code examples to exemplify what they consider good and bad code, respectively. Readability and structure were used most commonly as defining properties for quality code. Together with documentation, they were also suggested as the most common target properties for quality improvement. When discussing actual code, developers focused on structure, comprehensibility and readability as quality properties. When analyzing relationships between properties, the most commonly talked about target property was comprehensibility. Documentation, structure and readability were named most frequently as source properties to achieve good comprehensibility. Some of the most important source code properties contributing to code quality as perceived by developers lack clear definitions and are difficult to capture. More research is therefore necessary to measure the structure, comprehensibility and readability of code in ways that matter for developers and to relate these measures of code structure, comprehensibility and readability to common software quality attributes.
Impact of different levels of handling on Solea senegalensis culture: effects on growth and molecular markers of stress
Authors: Valcarce David G. , Riesco Marta F. , Martínez-Vázquez Juan Manuel , Villanueva José Luis Rodríguez , Robles Vanesa 
Published: September 2023

AbstractAquaculture routine practices may cause stress induction on the fish and compromise their welfare affecting the production. This experiment aimed to evaluate the potential links between handling during culture with stress responses and growth on Senegalese sole (Solea senegalensis). We worked with two fish cohorts in terms of initial body weight and culture stage: Trial 1 included specimens in the fattening stage (226 ± 4.96 g) and Trial 2 animals in the pre-fattening stage (27.20 ± 0.44 g). The tested culture protocol, which lasted 6 and 4 months for Trial 1 and 2, respectively, mainly reduced handling-derived stressors in the experimental tanks via lowering routine samplings to a minimum. This decrease of the handling-derived stress was reflected in both trials with lower concentration of circulating cortisol in blood plasma from the experimental fish when compared to controls. Moreover, the proposed protocol promoted higher growth in the fish cultured in the less disturbing protocol in Trial 2. Higher specific growth rates and mean body weight and length were reported. In order to further explore the potential beneficial effects of our protocol, we studied the musculoskeletal from Trial 2 gene expression of key genes regulating glucocorticoid signaling pathway and apoptosis: glucocorticoid receptors 1 and 2 (gr1, gr2), heat shock protein 90 AA (hsp90aa), and caspase 6 (casp6). In line with the cortisol reduced level in this trial, gr1, hsp90aa, and casp6 genes showed lower expression in the samples coming from the experimental group. The findings of this study provide valuable information to the aquaculture industry for the management of Solea senegalensis stress and welfare.