bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ru Supported on p‐phthalic acid‐Mn Derived from a Mn Metal–Organic Framework for Thermo‐ and Electrocatalytic Synthesis of Ethylene‐D4 Glycol
Authors: Shao Fangjun , Ma Fandong , Li Yuanan , Jiang Wenjie , Wei Zhongzhe , Zhong Xing , Wang Hong , Wang Ligeng , Wang Jianguo 
Published: April 2023

AbstractDeuterium‐labeled polyols are one of the most extensive applied chemicals in biochemistry and biophysics. However, the deuteriation still is insufficient, exhibiting a low deuterated ratio and indistinct reaction mechanism. Herein, Ru supported on MnBCD (MnBDC, derived from Mn p‐phthalic acid metal‐organic framework) as nanocatalyst with an agglomerated sheet‐type structure; this allows the possibility of achieving both thermo‐ and electrocatalytic hydrogen isotope exchange (HIE) reaction. Furthermore, XPS characterization confirmed that the specific structural changes in the electron density of Ru outer layers were modulated through the impregnation and reduction processes. According to the change of outer electronic structure, hydrogen spillover and electron‐rich flow promote the reaction of the catalyst in thermo‐ and electrocatalytic systems, respectively. In addition, the results indicate that a high deuterated ratio of 97 % can be obtained, hence the catalytic technology has enormous potential for the synthesis of a broad variety of deuterium‐labeled compounds.
Attenuation of the severity and changes in the microbiota in an animal model of primary biliary cholangitis by FOXP3− regulatory T cells
Authors: Chen Yi‐Lien , Chen Szu‐Ying , Chuang Ya‐Hui , Chiang Bor‐Luen 
Published: April 2023

AbstractBackgroundPrimary biliary cholangitis (PBC), an autoimmune liver disease, presents with progressive damage to the intrahepatic bile ducts with infiltrating mononuclear cells and the appearance of anti‐mitochondrial antibodies (AMAs). The initiation of autoimmune liver disease is permissively mediated by dysfunctional regulatory T cells (Treg cells). Naïve CD4+ T cells cultured with splenic B220+ cells without additional cytokines or chemicals can differentiate into specific types of Treg cells (Treg/B cells) without expressing forkhead box P3. In this study, we explored the effects of Treg/B cells on disease severity and changes in intestinal microbiota in a murine model of PBC.MethodsTreg/B cells were administered to 2‐octenoic acid‐induced PBC mice. Enzyme‐linked immunosorbent assay, flow cytometry and histopathological techniques were used to evaluate the severity of PBC and to assess its therapeutic effect. Diversity of the intestinal microbiota was determined using 16S rRNA sequencing. The suppressive mechanisms of Treg/B cells were investigated using the bone marrow‐derived dendritic cells (BMDCs).ResultsTreg/B‐cell treatment significantly decreased the levels of serum AMAs against pyruvate dehydrogenase complex E2, lowered the levels of serum bile acids, attenuated inflammatory cell infiltration, reduced dendritic cell activation, altered the population of T cells in the liver and alleviated liver collagen synthesis in PBC mice. In addition, the Treg/B‐cell treatment changed the faecal microbial diversity in PBC mice. Furthermore, Treg/B‐cell treatment decreased the levels of proinflammatory cytokines and expression of costimulatory molecules in BMDCs. This inhibitory effect was partially mediated by the cytotoxic T‐lymphocyte‐associated antigen 4 pathway.ConclusionTreatment with Treg/B cells in a murine model of PBC attenuated liver inflammation and altered the gut microbiota. Immune regulation of Treg/B cells may be a potential therapeutic strategy for treating autoimmune liver disease.
FURIN regulates cytotoxic T‐lymphocyte effector function and memory cell transition in mice
Authors: Ojanen Markus J.T. , Caro Fernanda Munoz , Aittomäki Saara , Ploquin Mickaël J. , Ortutay Zsuzsanna , Pekkarinen Meeri , Kesseli Juha , Vähätupa Maria , Määttä Juuso , Nykter Matti , Junttila Ilkka S. , Järvinen Tero A.H. , O´Shea John J. , Biron Christine A. , Pesu Marko 
Published: April 2023

AbstractThe proprotein convertase subtilisin/kexins (PCSKs) regulate biological actions by cleaving immature substrate proteins. The archetype PCSK, FURIN, promotes the pathogenicity of viruses by proteolytically processing viral proteins. FURIN has also important regulatory functions in both innate and adaptive immune responses but its role in the CD8+ CTLs remains enigmatic. We used a T‐cell‐specific FURIN deletion in vivo to demonstrate that FURIN promotes host response against the CTL‐dependent lymphocytic choriomeningitis virus by virtue of restricting viral burden and augmenting interferon gamma (IFNG) production. We also characterized Furin KO CD8+ T cells ex vivo, including after their activation with FURIN regulating cytokines IL12 or TGFB1. Furin KO CD8+ T cells show an inherently activated phenotype characterized by the upregulation of effector genes and increased frequencies of CD44+, TNF+, and IFNG+ cells. In the activated CTLs, FURIN regulates the productions of IL2, TNF, and GZMB and the genes associated with the TGFBR‐signaling pathway. FURIN also controls the expression of Eomes, Foxo1, and Bcl6 and the levels of ITGAE and CD62L, which implies a role in the development of CTL memory. Collectively, our data suggest that the T‐cell expressed FURIN is important for host responses in viral infections, CTL homeostasis/activation, and memory development.
Successful treatment of immune‐related cystitis with bladder hydrodistension
Authors: Anraku Tsutomu , Hashidate Hideki , Imai Tomoyuki , Kawakami Yoshiaki 
Published: April 2023

IntroductionAlthough immune checkpoint inhibitors offer significant therapeutic benefits to patients with advanced cancer, they can also cause a variety of immune‐related adverse events. As immune checkpoint inhibitors are being widely used, rare immune‐related adverse events are being reported.Case presentationA 70‐year‐old man with advanced salivary duct carcinoma was treated with pembrolizumab following radiotherapy. After receiving two doses of pembrolizumab, the patient experienced symptoms such as micturition pain and hematuria. Immune‐related cystitis was suspected, and the patient underwent a bladder biopsy and bladder hydrodistension. Histological analysis revealed non‐neoplastic bladder mucosa with CD8‐positive lymphocyte‐dominant inflammatory cell infiltration, consistent with immune‐related cystitis. The patient's bladder symptoms improved postoperatively without steroid administration.ConclusionAlthough steroids are commonly administered to treat immune‐related adverse events, bladder hydrodistension may be a promising treatment option for immune‐related cystitis to avoid administration of steroids, which may impair the therapeutic effect of immune checkpoint inhibitors.
The complex role of the community in the determination of well‐being and hope among divorced Muslim women
Authors: Abu‐Ras Ruba , Itzhaki‐Braun Yael 
Published: April 2023

AbstractBased on social capital theory, in the current study, we examined the contribution of background variables (education and living with/without parents), a personal resource (religiosity), and two communal resources (a sense of community, and both positive and negative societal conditional regard) to the well‐being and hope of divorced women from the Muslim community in Israel. The study included 125 women between the ages of 20 and 60 (M = 36, SD = 9.10). A path analysis model indicated a sense of community as a protective factor that directly contributed to well‐being and hope and also mediated positively between education and religiosity and between well‐being and hope. However, societal conditional negative regard (SCNR) made a negative contribution to well‐being and hope, both directly and indirectly via the sense of community. In the discussion, we highlight the conflict experienced by Muslim divorced women: between remaining part of the Muslim community and undergoing SCNR.
Materialism and life satisfaction relations between and within people over time: Results of a three‐wave longitudinal study
Authors: Jaspers Esther D. T. , Pandelaere Mario , Pieters Rik G. M. , Shrum L. J. 
Published: April 2023

AbstractThe negative association between materialism and life satisfaction is well‐documented, but it is unclear what the directionality of the association is. To address this issue, we (a) conducted a three‐wave longitudinal study (N = 6551) over 3 years and examined the bidirectional relations between life satisfaction and materialism as a composite measure and with each of its three facets (happiness, success, and centrality), and (b) estimated Random Intercept Cross‐Lagged Panel Models (RI‐CLPMs) that separate inter‐ and intra‐individual effects and compared them with traditional CLPMs that do not. The traditional CLPM showed bidirectional negative associations between composite materialism and life satisfaction and strong negative bidirectional association for the happiness facet, but positive effects of the centrality facet on life satisfaction. However, and importantly, the RI‐CLPM revealed that these relations exist predominantly between people. Within people, materialism does not impact life satisfaction, but life satisfaction does impact the happiness facet negatively. These findings challenge common ideas that the direction of the effect is from materialism to life satisfaction and that it is unilaterally negative.
Valorization of biomass ash for the effective removal of dipyrone from water: an efficient and low‐cost option
Authors: dos Reis Oliveira Marina , Paulino Isabela Maria Reck , Resende Jayana Freitas , Simão Lisandro , Vieira Marcelo Fernandes , Bergamasco Rosângela , Vieira Angélica Marquetotti Salcedo 
Published: April 2023

AbstractBackgroundIn order to propose a destination for the bottom ash generated from biomass burning, its morphology, functional groups and mineral phases were studied. Dipyrone has been extensively used as an antipyretic, increased due to cases of COVID‐19, and due to excretion by urine, incorrect disposal and industrial effluents has been destined to wastewater, being harmful to human and animal life. The present study proposes using biomass ash for the adsorption of dipyrone.ResultsThe characterization of biomass ash shows a sufficient surface area size for adsorption, and a mainly amorphous structure with some peaks of quartz, calcite and other mineral phases. The results show that the kinetic model which best describes the adsorption is the pseudo‐first‐order model. The Langmuir model best fits at 25 °C, and the Freundlich model best describes the adsorption at 35 and 45 °C. The thermodynamic parameters indicated that the process is endothermic with a maximum adsorptive capacity of 65.27 mg g−1. In addition, the adsorption is spontaneous, disordered and chemical. The ionic strength study reveals that the adsorbent is promising for real effluent treatment and there is evidence that electrostatic interaction is not the primary adsorptive mechanism, agreeing with the result obtained from pH testing. The proposed mechanism for dipyrone removal involves hydrogen bonds, π bonds and electron donor–acceptor complex.ConclusionsThe results are promising in comparison with recent literature and solve two environmental problems: biomass bottom ash disposal and pharmaceutical removal in aqueous medium. The ash may be regarded as a low‐cost and environmentally friendly adsorbent. © 2023 Society of Chemical Industry (SCI).
Prognostic Value of Left Ventricular Longitudinal Function and Myocardial Fibrosis in Patients With Ischemic and Non‐Ischemic Dilated Cardiomyopathy Concomitant With Type 2 Diabetes Mellitus: A 3.0 T Cardiac MR Study
Authors: Zhang Hong‐Kai , Du Yu , Shi Chun‐Yan , Zhang Nan , Gao Hui‐Qiang , Zhong Yong‐Liang , Wang Mao‐Zhou , Zhou Zhen , Gao Xue‐Lian , Li Shuang , Yang Lin , Liu Tong , Fan Zhan‐Ming , Sun Zhong‐Hua , Xu Lei 
Published: April 2023

BackgroundPoorly controlled type 2 diabetes mellitus (T2DM) is known to result in left ventricular (LV) dysfunction, myocardial fibrosis, and ischemic/nonischemic dilated cardiomyopathy (ICM/NIDCM). However, less is known about the prognostic value of T2DM on LV longitudinal function and late gadolinium enhancement (LGE) assessed with cardiac MRI in ICM/NIDCM patients.PurposeTo measure LV longitudinal function and myocardial scar in ICM/NIDCM patients with T2DM and to determine their prognostic values.Study TypeRetrospective cohort.PopulationTwo hundred thirty‐five ICM/NIDCM patients (158 with T2DM and 77 without T2DM).Field Strength/Sequence3T; steady‐state free precession cine; phase‐sensitive inversion recovery segmented gradient echo LGE sequences.AssessmentGlobal peak longitudinal systolic strain rate (GLPSSR) was evaluated to LV longitudinal function with feature tracking. The predictive value of GLPSSR was determined with ROC curve. Glycated hemoglobin (HbA1c) was measured. The primary adverse cardiovascular endpoint was follow up every 3 months.Statistical TestsMann–Whitney U test or student's t‐test; Intra and inter‐observer variabilities; Kaplan–Meier method; Cox proportional hazards analysis (threshold = 5%).ResultsICM/NIDCM patients with T2DM exhibited significantly lower absolute value of GLPSSR (0.39 ± 0.14 vs. 0.49 ± 0.18) and higher proportion of LGE positive (+) despite similar LV ejection fraction, compared to without T2DM. LV GLPSSR was able to predict primary endpoint (AUC 0.73) and optimal cutoff point was 0.4. ICM/NIDCM patients with T2DM (GLPSSR < 0.4) had more markedly impaired survival. Importantly, this group (GLPSSR < 0.4, HbA1c ≥ 7.8%, or LGE (+)) exhibited the worst survival. In multivariate analysis, GLPSSR, HbA1c, and LGE (+) significantly predicted primary adverse cardiovascular endpoint in overall ICM/NIDCM and ICM/NIDCM patients with T2DM.ConclusionsT2DM has an additive deleterious effect on LV longitudinal function and myocardial fibrosis in ICM/NIDCM patients. Combining GLPSSR, HbA1c, and LGE could be promising markers in predicting outcomes in ICM/NIDCM patients with T2DM.Evidence Level3Technical Efficacy5
Population dynamics and harvest management of eastern mallards
Authors: Roberts Anthony J. , Hostetler Jeffrey A. , Stiller Joshua C. , Devers Patrick K. , Link William A. 
Published: April 2023

AbstractManaging sustainable harvest of wildlife populations requires regular collection of demographic data and robust estimates of demographic parameters. Estimates can then be used to develop a harvest strategy to guide decision‐making. Mallards (Anas platyrhynchos) are an important species in the Atlantic Flyway for many users and they exhibited exponential growth in the eastern United States between the 1970s and 1990s. Since then, estimates of mallard abundance have declined 16%, prompting the Atlantic Flyway Council and United States Fish and Wildlife Service to implement more restrictive hunting regulations and develop a new harvest strategy predicated on an updated population model. Our primary objective was to develop an integrated population model (IPM) for use in an eastern mallard harvest management strategy. We developed an IPM using annual estimates of breeding abundance, 2‐season banding and recovery data, and hunter‐harvest data from 1998 to 2018. When developing the model, we used novel model selection methods to test various forms of a sub‐model for survival including estimating the degree of harvest additivity and any age‐specific trends. The top survival sub‐model included a negative annual trend on juvenile survival. The IPM posterior estimates for population abundance tracked closely with the observed estimates and estimates of mean annual population growth rate ranged from 0.88 to 1.08. Our population model provided increased precision in abundance estimates compared to survey methods for use in an updated harvest strategy. The IPM posterior estimates of survival rates were relatively stable for adult cohorts, and annual growth rate was positively correlated with the female age ratio, a measure of reproduction. Either or both of those demographic parameters, juvenile survival or reproduction, could be a target for management efforts to address the population decline. The resulting demographic parameters provided information on the equilibrium population size and can be used in an adaptive harvest strategy for mallards in eastern North America.
A compact formulation for the base station deployment problem in wireless networks
Authors: Avella Pasquale , Calamita Alice , Palagi Laura 
Published: April 2023

AbstractThis article considers the base station deployment problem in a wireless network. The natural formulation of this problem usually leads to numerical and memory issues, preventing users from dealing with real‐world cases. We provide a compact reformulation that allows us to get beyond the drawbacks of the natural formulation. Tests are done on ten instances derived from realistic LTE scenarios. The computational results show that the proposed reformulation enables mixed‐integer programming solvers to provide an optimal solution in a short amount of time.
The role of patient activation in self‐care behaviours of Korean older adults with heart failure
Authors: Son Youn‐Jung , Lee Suk Jeong , Kim Sun‐Hee 
Published: April 2023

AbstractAimThis study was aimed at investigating the level of patient activation, and its association with self‐care behaviours in older people with heart failure.DesignCross‐sectional secondary data analysis was conducted.MethodsWe included a total of 182 Korean patients with heart failure who were aged ≥65 years for a cardiovascular outpatient clinic visit. Baseline characteristics, the Patient Activation Measure (PAM), health literacy, disease knowledge and self‐care behaviours were collected via a self‐administered questionnaire.ResultsThe proportion of patient activation at Levels 1 and 2 was 22.5% and 14.3%, respectively. Highly activated patients had a high level of health literacy, disease knowledge and self‐care behaviours. After adjusting for confounding factors, we observed that patient activation was the only statiscally significant predictor of self‐care behaviours among older people with heart failure. Healthcare professionals should help patients take active roles in their self‐care through a comprehensive needs assessment including health literacy and disease knowledge.
The use of a modified rescue cervical cerclage in a diamniotic dichorionic twin pregnancy that had cervical dilatation
Authors: Bailey Michelle , Reid Marvin , DaCosta Vernon 
Published: April 2023

AbstractObjectiveWe describe the successful utilization of a modified rescue cerclage in a 32‐year‐old G4 P1213 woman of Afro‐Caribbean descent with a Diamniotic Dichorionic twin gestation who presented at 20 weeks and 2 days for a routine anomaly scan and was found to have a dilated (1.7 cm) and short (0.49 cm) cervix.DesignA standard prophylactic cervical cerclage was done at 12 weeks' gestation using Mersilene™ tape. For the rescue cerclage, the client was placed in a steep Trendelenburg position, with back filling of the bladder. The cervix was grasped with ring forceps, and an inflated foley balloon catheter was introduced into the cervical opening to aid in reduction of membranes. In addition to the initial cerclage, two 1‐ Prolene™ sutures were inserted distally to the tape and a second Mersilene™ tape was inserted proximally at the vesicocervical junction (reinforcement cerclages). The first Prolene™ was to provide additional structural support to prevent prolapse of the membrane. The second Prolene™ was used to close the external cervical or to minimize the risk of an ascending infection. The procedure was uneventful and postoperatively she was treated with antibiotics, vaginal micronized progesterone and venous thromboembolism prophylaxis. The membranes remained intact.ResultThe twins were successfully delivered by a scheduled repeat caesarean section at 36 weeks with Twin 1 Apgar scores of 9 and 9 at 1 and 5 min, respectively, and Twin 2 Apgar scores of 8 and 10, respectively.ConclusionIn the context of a challenging obstetric history as in this case, a more aggressive approach inclusive of reinforcement cerclage may be considered. The successful outcomes in this case further reiterates the need for larger clinical trials with pregnant individuals with larger cervical dilations at entry.
Share density‐based clustering of income data
Authors: Condino Francesca 
Published: April 2023

AbstractThe Lorenz curve is a fundamental tool for analyzing income and wealth distribution and inequality. Indeed, the Lorenz curve and its derivative, the so‐called share density, provide valuable information regarding inequality. There is a widely recognized connection between the Lorenz curve and elements from information theory field. Starting from this evidence, the aim of this work is to compare the income inequality of different subgroups, by using a proper dissimilarity measure, borrowed from information theory, between parametric share densities. This measure is then considered for clustering purposes. To this end, a dynamic clustering algorithm is considered to group unconventional data, such as density functions. Finally, an application, regarding data from Survey on Households Income and Wealth (SHIW) by Bank of Italy, is shown.
Modeling and maximum likelihood based inference of interval‐censored data with unknown upper limits and time‐dependent covariates
Authors: Wu Jing , Geng Lijiang , Starkweather Angela , Chen Ming‐Hui 
Published: April 2023

AbstractDue to the nature of study design or other reasons, the upper limits of the interval‐censored data with multiple visits are unknown. A naïve approach is to treat the last observed time as the exact event time, which may induce biased estimators of the model parameters. In this paper, we first develop a Cox model with time‐dependent covariates for the event time and a proportional hazards model with frailty for the gap time. We then construct the upper limits using the latent gap times to resolve the issue of interval‐censored event time data with unknown upper limits. A data‐augmentation technique and a Monte Carlo EM (MCEM) algorithm are developed to facilitate computation. Theoretical properties of the computational algorithm are also investigated. Additionally, new model comparison criteria are developed to assess the fit of the gap time data as well as the fit of the event time data conditional on the gap time data. Our proposed method compares favorably with competing methods in both simulation study and real data analysis.
Ni(OH)2 nanoparticles as a recyclable catalyst in acceptorless dehydrogenation of alcohols to acids/acid salts under aerobic conditions
Authors: Paul Tumpa , Saikia Partha Pratim , Borah Dhrubajit , Mahanta Nilkamal , Baruah Arabinda , Borah Jayanta M. , Saikia Bhaskar J. , Raidongia Kalyan , Gogoi Raj Kumar , Gogoi Raktim 
Published: April 2023

AbstractWe demonstrate herein the catalytic performance of unsupported Ni(OH)2 nanoparticles towards the dehydrogenation of primary alcohols to corresponding acids under aerobic conditions in refluxing toluene. An assortment of aromatic and aliphatic carboxylic acids/acids salts was prepared from corresponding alcohols in moderate to excellent yields. Interestingly, the protocol can also be employed to synthesize carboxylic acids on a gram scale, demonstrating the practical utility of the method. Mechanistic studies suggest that the reaction proceeds through an acceptorless dehydrogenation strategy and follow both Cannizzaro and catalytic dehydrogenative path. Broad substrate scope, operational simplicity, low cost, and reusability are the most interesting features of the current heterogeneous catalytic protocol described herein.