bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Antibiotic-Impregnated Spacers on Bone Healing in an Animal Model of the Induced Membrane Technique
Authors: Sun Hening , Godbout Charles , Ryan Gareth , Ali Ikran , Higgins James , Hoit Graeme , Hall Jeremy , Halai Mansur , Khoshbin Amir , Schemitsch Emil H. , Nauth Aaron 
Published: February 2025

Background:
Surgeons performing the induced membrane technique (IMT) often incorporate antibiotics into the spacer at the first stage of the surgical procedure to prevent or treat infection. However, the effect of antibiotic use on subsequent bone healing is not clear. This study aimed to investigate if antibiotic-impregnated spacers impact subsequent bone healing in a rat model of the IMT.

Methods:
Inbred male rats (Fischer 344) were randomly divided into 3 groups according to the antibiotic dose in the spacer: (1) control (no antibiotics), (2) low-dose (1.2 g tobramycin and 1.0 g vancomycin per 40 g of polymethylmethacrylate [PMMA]), and (3) high-dose (3.6 g tobramycin and 3.0 g vancomycin per 40 g of PMMA). We created a 5-mm segmental defect in the right femoral diaphysis. The bone was stabilized with a plate and screws, and the assigned spacer was inserted into the defect. Four weeks later, the spacer was removed and bone graft was placed within the defect. Radiographs made 12 weeks after grafting were scored according to union status and degree of bone healing. Micro-computed tomographic (CT) analysis and biomechanical testing were also performed at 12 weeks.

Results:
Full radiographic union was achieved in 10 (83%) of 12 control animals, 13 (100%) of 13 low-dose animals, and 8 (62%) of 13 high-dose animals (high-dose compared with low-dose: risk ratio, 11.0; p = 0.039). The control group demonstrated higher bone volume compared with the high-dose group (mean difference, 9.0 mm3; p = 0.039), and there was a trend toward higher bone volume in the low-dose group compared with the high-dose group (mean difference, 8.1 mm3; p = 0.06). The biomechanical results demonstrated that maximum stiffness was significantly higher in the low-dose group compared with the high-dose group (mean difference, 14.1 N*mm/degree; p = 0.009).

Conclusions:
Our results demonstrated that low doses of antibiotics in PMMA spacers used for the IMT did not impair bone healing. However, high doses of antibiotics demonstrated inferior bone healing.

Clinical Relevance:
The addition of high-dose antibiotics to the PMMA spacers used for the IMT may result in impaired bone healing and should be used with caution.
First Evidence of Coexistence of Pseudo Pelger-Huët Anomaly and Balanced Translocation in a two decades retrospectively exposed human subject
Authors: Chaurasia Rajesh Kumar , Pathak Ranjana S. , Goel Anjana , Shirsath Kapil B. , Bhat Nagesh N. , Khan Arshad , Sapra Balvinder K. 
Published: February 2025

Abstract

This study investigated the long-term stability of cytogenetic and morphological markers, including dicentric chromosomes (DC), unbalanced translocation (UT), balanced translocation (BT), and Pseudo Pelger-Huët Anomaly (PHA), in a radiation worker exposed to an acute dose of 60Co-γ radiation. Initial dose assessment, immediately after exposure via thermoluminescent dosimeters (TLDs) and DC, yielded a physical dose of 438.8 mGy and a biological dose of 398 mGy respectively. A follow-up biodosimetry evaluation, conducted 24 years postexposure, yielded a dose estimate of 449 mGy on the basis of BT, closely matching the initial TLD measurement (+2.3% relative error). In contrast, the DC, UT, and micronuclei (MN) frequencies fell within the background range, confirming their instability over time. We also assessed the presence of PHA in blood smears from the same volunteer. PHA, a morphological marker of neutrophils originating exclusively in vivo from bone marrow progenitor cells, demonstrated a more than twofold increase in frequency compared to background levels, suggesting an association with radiation exposure. This is the first report of concurrent BT and PHA persistence in the same individual, demonstrating the stability of these biomarkers for retrospective dose estimation. BT offered reliable dose reconstruction decades after exposure. We could not translate the PHA yield into an absorbed dose, as no in-house dose‒response curve was established.
Characterization of enteric pathogens in Harare, Zimbabwe using environmental surveillance and metagenomics
Authors: Cheung Samantha , Zhou Nicolette A. , Ruhanya Vurayai , Jesser Kelsey , Nezomba Ignitious , Musvibe John , Manyisa Brendon , Nyandoro George , Chibukira Paradzai , Mukaratirwa Arnold , Muserere Simon Takawira , Masunda Kudzai , Ong Angelo , Meschke John Scott 
Published: February 2025

ABSTRACT
High diarrheal disease burden remains an urgent concern in low- and middle-income countries, greatly affecting children under the age of 5 years and those living with HIV and AIDS. Treatment of infectious diseases has also become increasingly difficult with the rapid rise of antimicrobial resistance (AMR). Environmental surveillance of wastewater can supplement gaps in clinical surveillance as residents on a sewage system contribute to the wastewater, providing simple, composite samples that can improve understanding about both pathogens and AMR in the community. This study evaluated the effectiveness of environmental surveillance with shotgun metagenomics as a tool to characterize a broad range of enteric pathogens, antibiotic resistance genes, and virulence factor genes (VFGs) in wastewater from six neighborhoods in Harare, Zimbabwe. Alpha and beta diversity of the microbial community were similar between high-income and low-income suburbs. Enteric pathogens of high AMR and clinical concern, including Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella enterica, were detected in all samples. The top VFGs encoded for delivery, adherence, and motility, functions important in toxin secretion, colonization, and immune modulation. The findings provide a foundation for future studies to explore environmental surveillance and shotgun metagenomics as a public health monitoring tool for enteric diseases.
Prediksi Kesulitan Keuangan Dengan Menggunakan Model Altman Modifikasi Z-Score
Authors: Wahyuni Sri 
Published: February 2025

Textile industry is contracted due to the Covid-19 pandemic, reduction of export, increase of import, and the spread of thrifting trend. This unfavorable condition has put losses to the issuers of textile industry. Here financial distress prediction analysis is crucial since the earlier the financial distress is detected, the more useful information received by internal parties. Such information is used by the stakeholders as a consideration in their decision-making. The objective of this research is to identify and analyze the prediction of financial distress obtained from the use of the modified Altman Z”-Score. Using purposive sampling technique, twelve companies were selected as the sample of this quantitative descriptive study. The financial distress was measured using the modified Altman Z”-Score, which incorporates four financial ratios. This study finds that seven companies (58%) are predicted to have financial distress for three years, that two companies (17%) have fluctuating financial conditions, that two companies (17%) improves their financial performance and tat one company (8%) has good financial condition for three years. The results of this research are useful for investors as a signal for the consideration of investment decision-making and for companies as an early warning and early cues for evaluation to prevent bankruptcy.

Abstrak
Industri tekstil terkontraksi akibat pandemi Covid-19, penurunan ekspor tekstil, peningkatan impor produk tekstil serta maraknya trend thrifting yang mengakibatkan emiten tekstil mengalami kerugian. Analisis prediksi kesulitan keuangan penting karena semakin dini tanda kesulitan keuangan terdeteksi, maka akan semakin baik bagi pihak internal serta dapat memberikan informasi yang berguna sebagai sinyal bagi pemangku kepentingan untuk bahan pertimbangan dalam pengambilan keputusan. Penelitian ini bertujuan untuk mengetahui dan menganalisis prediksi kesulitan keuangan dengan menggunakan model Altman Modifikasi Z”-Score. Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Pemilihan sampel menggunakan teknik purposive sampling sehingga didapatkan sampel berjumlah 12 perusahaan. Kesulitan keuangan diukur dengan menggunakan model Altman Modifikasi Z"-Score yang memanfaatkan empat rasio keuangan. Hasil penelitian menunjukkan bahwa terdapat 58% atau 7 perusahaan diprediksi mengalami kesulitan keuangan selama tiga tahun, 17% atau 2 perusahaan kondisi keuangannya berfluktuasi, dan 17% atau 2 perusahaan mengalami peningkatan kinerja keuangan dan 8% atau 1 perusahaan memiliki keuangan yang sehat selama 3 tahun. Hasil penelitian ini berguna bagi investor sebagai sinyal untuk bahan pertimbangan dalam pengambilan keputusan investasi serta bagi perusahaan sebagai tanda peringatan dini dan evaluasi untuk mencegah terjadinya kebangkrutan.
Pengaruh Kinerja Keuangan Perusahaan Terhadap Return Saham
Authors: Ramadhan Bimansyah Saktiaji , Aisjah Siti 
Published: February 2025

The objective of this research is to identify the effects of company financial performance, which is proxied by Quick Ratio (QR), Debt-to-Equity Ratio (DER), and Earnings Per Share (EPS), on the stock returns of mining companies. The population is 47 mining companies listed on the Indonesia Stock Exchange that have consecutively paid their dividend during the 2016-2020 period. Using purposive sampling, ten of them were selected as the sample. The data of this research was analyzed using descriptive statistics, classical assumption test, hypothesis test (R2, F, and t tests), and multiple linear regression. The results of the analyses indicate that quick ration significantly influences stock return, that dent-to-equity ratio significantly affects stock return, return on equity significantly impacts stock return, and that earning per share significantly influences stock return. Therefore, it can be concluded that financial performance has significant effects on stock return.

Abstrak
Tujuan penelitian ini untuk mengetahui Pengaruh Kinerja Keuangan Perusahaan yaitu quick ratio (QR), debt to equity ratio (DER), return on equity (ROE), earning per share (EPS) terhadap return saham pada perusahaan pertambangan. Populasi penelitian ini adalah perusahaan pertambangan yang terdaftar di Bursa Efek Indonesia (BEI) yang membayarkan dividen secara terus menerus selama periode 2016-2020. Metode pengambilan sampel dalam penelitian ini menggunakan purposive sampling menghasilkan 20 sampel perusahaan dengan total keseluruhan populasi 47. Metode analisis data yang digunakan dalam penelitian ini yaitu statistik deskriptif dan menggunakan uji asumsi klasik dan uji hipotesis (uji R2, F, dan uji t) dengan metode analisis regresi linier berganda. Berdasarkan hasil analisis menunjukkan quick ratio berpengaruh signifikan terhadap return saham, debt to equity ratio berpengaruh signifikan terhadap return saham, return on equity berpengaruh signifikan terhadap return saham, earning per share berpengaruh signifikan terhadap return saham. Hasil tersebut menunjukkan bahwa kinerja keuangan perusahaan berpengaruh signifikan terhadap return saham.
Association of body mass index pre-pregnancy with hypertension disorders of pregnancy in Bantul District Special Region of Yogyakarta
Authors: Cahyaningtyas Ayu , Hakimi Mohammad 
Published: February 2025

Purpose: This research was to identify the relationship between body mass index pre-pregnancy and the incidence of hypertension in pregnancy in Bantul District in 2020.
Methods: This research used a retrospective cohort design based on secondary data from an online maternal cohort with SIPIA Bantul in the Bantul district in 2020. The effect size was calculated using Relative Risk (RR) from bivariate chi-square, multivariate binomial regression, and stratification by Mantel-Haenszel. The total sample of this research was 670 pregnant women.
Results: Bivariate analysis results showed that there was body mass index pre-pregnancy (RR: 1.45; CI 95%: 1.220 – 1.730; p-value=0,00), mother age (RR: 1.47; CI 95%: 1.243 – 1.745; p-value=0,00), upper arm circumference (RR: 1.45; CI 95%; 1.194 – 1.761; p-value=0,001), and gestational weight gain (RR: 1,34; CI 95%: 1.123 – 1.598; p-value=0,002) have significant association with hypertension in pregnancy in Bantul District 2020. The multivariate analysis showed that body mass index pre-pregnancy and mother's age were the most significant variables with hypertension in Bantul District 2020. The stratification analysis showed that maternal age, upper arm circumference, gestational weight gain, and parity were not confounding. Still, there were modifying effects between body mass index pre-pregnancy and the incidence of hypertension in pregnancy in Bantul District in 2020.
Conclusion: Pregnant women who are overweight and obese can increase the incidence of hypertension in pregnancy in Bantul District 2020. Collaboration with nutritionist workers needs to be done to reduce the incidence of hypertension in pregnancy in Bantul District.
Исследование уровня развития критического мышления у подростков
Authors: Афоничев Г.А. , Яковлева Е.В. 
Published: February 2025

Статья посвящена вопросу диагностирования уровня развития критического мышления у подростков, обучающихся в общеобразовательной организации. В работе доказана необходимость формирования критического мышления у учащихся, приведен анализ понятия «критическое мышление», на основе анализа определены критерии и показатели сформированности критического мышлении у подростков, дана характеристика уровней. В статье указаны диагностические методики, которые позволяют определить уровень сформированности критического мышления у учащихся 8–9 классов. Представлены результаты замеров уровня развития критического мышления у подростков.
The article considers diagnostics of the level of’critical thinking development of adolescents studying in a comprehensive educational institution. The study substantiates the necessity of fostering critical thinking in students and provides an analysis of the concept of "critical thinking." Based on this analysis, criteria and indicators of critical thinking formation in adolescents are identified, and a description of its developmental levels is given in the article. The article specifies diagnostic methodologies that allow for the assessment of the level of critical thinking development in 8th–9th grade students, and gives the results of measurements of adolescents' critical thinking development.
Pengaruh Inquiry Learning terhadap Hasil Belajar Siswa pada Materi Gelombang Bunyi di SMA
Authors: Sihotang Lilis Susanti , Hakim Abd 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran inkuiri terbimbing terhadap hasil belajar fisika siswa SMA pada gelombang Bunyi. Penelitian ini merupakan jenis penelitian Quasi eksperimen dengan desain two group pretes postes design. Populasi dalam penelitian ini adalah seluruh kelas XI MIPA SMAN 2 Percut Sei Tuan T.P 2022/2023 dan sampel dalam penelitian ini adalah kelas XI B (kelas eksperimen) dan XI A (kelas kontrol) yang diambil dengan cara cluster random sampling. Instrumen yang digunakan adalah tes hasil belajar berbentuk pilihan berganda sebanyak 10 soal dan aktivitas siswa dengan menggunakan lembar observasi. Hasil penelitian diperoleh bahwa nilai rata- rata pretest dan postest di kelas eksperimen adalah 28,33 dan 72,66 sedangkan di kelas kontrol adalah 30,66 dan 64,66. Analisis data dilakukan dengan uji t diperoleh bahwa = . Sehingga dapat disimpulkan bahwa ada pengaruh yang signifikan dari model pembelajaran inkuiri terhadap hasil belajar siswa pada materi gelombang bunyi.Kata Kunci: Inquiry Learning , Hasil Belajar, Gelombang Bunyi
Smart Maritime Surveillance: Leveraging YOLO Detection and Blockchain traceability for Vessel Monitoring
Authors: Ezzeddini Lotfi , Affes Nesrine , Ktari Jalel , Frikha Tarek , Halima Riadh Ben , Hamam Habib 
Published: February 2025

Abstract
This paper presents a comprehensive study on utilizing artificial intelligence (AI) and advanced detection techniques for the study and monitoring of ships. The primary objective is to prevent various issues, such as ship intrusion detection, ship detection in satellite images, and ship detection in river images. To achieve this, the study proposes innovative methods; including enhancing the capabilities of YOLOv3 and YOLOv8 neural networks to improve the accuracy of ship detection. Additionally, the study leverages IoT technology for real-time tracking and integrates feature fusion modules for more effective information integration. A crucial aspect highlighted in this study is the necessity of controlling pollution caused by ships. By addressing this environmental concern, the study aims to contribute to the preservation of marine ecosystems and enhance maritime safety. The results of the study demonstrate a significant enhancement in detection accuracy, showcasing the potential of these advanced methods for efficient and reliable ship monitoring systems.
Glioblastoma mimicking autoimmune meningitis in an adult: A complex diagnostic challenge
Authors: Wakabayashi Mana , Ogiwara Toshihiro , Ito Kiyoshi , Sato Atsushi , Hanaoka Yoshiki , Kobayashi Kenichi , Shimizu Yusaku , Hongo Kazuhiro 
Published: February 2025

Background
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor with a poor prognosis. It commonly affects the brain and rarely spreads outside the central nervous system owing to barriers like the blood–brain barrier. We present a rare case of GBM with atypical features mimicking autoimmune meningitis, complicating the diagnosis.

Case Description
A 45-year-old previously healthy man presented with persistent headaches, dizziness, vomiting, neck pain, diplopia from bilateral abducens nerve palsy, and cognitive dysfunction. The cerebrospinal fluid analysis did not confirm meningitis, although initial clinical and radiological findings suggested autoimmune meningitis. Head magnetic resonance imaging (MRI) showed postcontrast leptomeningeal enhancement and meningeal thickening. A spinal MRI revealed a contrast-enhancing lesion at the L1 level with leptomeningeal enhancement of the spinal cord. Despite empirical steroid therapy, his condition worsened, resulting in severe neurological deficits and impaired consciousness. A biopsy confirmed GBM through L1-2 laminectomy. Although adjuvant therapy was scheduled, his health rapidly declined, and he passed away on the 24th day of admission before receiving chemotherapy or radiotherapy.

Conclusion
GBM can rarely present with noticeable symptoms and radiological features resembling autoimmune meningitis, posing diagnostic challenges. GBM cases involving spinal dissemination typically have a poorer prognosis, emphasizing the necessity of thorough diagnostic strategies. These should encompass histopathological biopsy and advanced imaging for optimal management, as delayed intervention significantly impacts survival. This report highlights the importance of maintaining a high level of suspicion for GBM and prompt intervention, including biopsy, in the presence of atypical clinical, radiological, and laboratory signs suggestive of meningitis.
Utilization of L5-S1 interbody cage in adult spinal deformity patients undergoing lumbar spinal osteotomies and spinopelvic fixation: A retrospective comparative study
Authors: Rostami Mohsen , Moghadam Navid , Rashidbeygi Milad , Roohollahi Faramarz , Shafizadeh Milad , Faghih Jouibari Morteza , Jafari Mohammad , Abbaspoor Mohammad Javad , Painmahalli Abolfazl , Bagherzadeh Sadegh 
Published: February 2025

Background
Adult spinal deformity (ASD) surgeries often face complications, such as pseudoarthrosis and rod fractures (RFs), particularly at the lumbosacral junction. While transforaminal lumbosacral interbody fusion (TLIF) at L5-S1 is thought to improve outcomes, its efficacy in major ASD surgeries remains unclear. This study aims to compare clinical and radiological outcomes and implant complications in patients undergoing spinopelvic fixation with or without L5-S1 TLIF.

Methods
A retrospective cohort study was conducted, including 157 ASD patients who underwent high-grade osteotomies and spinopelvic fixation from 2021 to 2024. Patients were divided into two groups: those with L5-S1 TLIF (C group, n = 71) and those without (NC group, n = 86). Outcomes included rod fracture (RF) rate, sagittal alignment, and patient-reported measures such as the Visual Analog Scale (VAS), Oswestry disability index (ODI), and 36-Item Short Form Survey (SF-36), assessed at baseline, 1, 6, and 12 months postoperatively.

Results
RFs were significantly lower in the C group (4% vs. 13%, P = 0.03). Improved postoperative sagittal vertical axis and pelvic tilt were noted in the C group (P < 0.01). Both VAS and ODI scores were significantly better at 6 and 12 months in the C group (P < 0.01), along with higher SF-36 scores. No significant differences in baseline characteristics, estimated blood loss, or operation time were observed.

Conclusion
The use of L5-S1 TLIF reduces RF rates, improves sagittal alignment, and clinical outcomes in ASD surgery. Incorporating TLIF at L5-S1 may optimize outcomes without increasing perioperative risks.
Reaktivität von Koordinationsverbindungen XX : Redoxverhaiten von Oxo-3,5-disulfobrenzcatechinato-vanadium(V)
Authors: Braun-Steinle D. , Fallab S. 
Published: February 2025

The oxydation of pyrocatechole-3,5-disulfonic acid by vanadium(V) in acidic solution has been studied spectrophotometrically. Analysis of kinetic data suggests two parallel reaction paths: (a) An initially formed intensely coloured VO2+ substrate complex reacts monomolecularily to give a semiquinone intermediate which is rapidly oxidized to the quinone by a second VO2+. (b) The VO2+-substrate complex is attacked directly by a second VO2+ yielding the quinone and 2 VO2+. Catalysis by Fe3+ is explained by reaction of the corresponding iron(III)-chelate of the substrate with VO2+.
PENINGKATAN KETERAMPILAN LITERASI SASTRA MELALUI STRATEGI SAMBEL TUKAR (SATU PEMBELAJARAN SATU KARYA) PADA TEMA CITA-CITAKU KELAS IV MI MISBAHUSSUDUR
Authors: Silmi Idam Matus 
Published: February 2025

Â Â Penelitian ini bertujuan untuk mengetahui peningkatan keterampilan literasi sastra melalui strategi Sambel Tukar (satu pembelajaran satu karya) pada tema cita-citakuku di kelas 4 MI Misbahussudur Malangsari. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) atau Classroom Action ResearchÂ menggunakan model penelitian dari Kemmis dan Tanggart yaitu perencanaan, tindakan, observasi, refleksi. Penelitian dilakukan dengan 2 siklus dengan subyek 18 siswa yang terdiri dari 8 laki-laki dan 10 perempuan. Analisis data yang digunakan peneliti yaitu analisis data dengan teknik deskriptif yang dikembangkan oleh Miles and Huberman. Hasil penelitian ini menunjukan keterampilan literasi sastra melalui strategi Sambel Tukar mengalami peningkatan baik individual maupun kasial. Peningkatan tesebut dilihat dari prosentase pada Siklus I yaitu 53,4% meningkat pada siklus II menjadi 72,6 %.Kata kunci: literasi, sastra, dan strategi sambel tukarÂ Â This study aims to find out the improvement of literary literacy skills through sambel tukar (one work learning) strategy on the theme of my goals in grade 4 mi Misbakhussudur Malangsari. This type of research is class action research (PTK) or Classroom Action Research using research models from Kemmis and Tanggrat namely planning, action, observation, reflection. The study was conducted in 2 cycles with subjects of 18 students consisting of 8 men and 10 women. Data analysis used by researchers is data analysis with descriptive techniques developed by Miles and Huberman. The results of this study show that literary skills through the Sambel Tukar strategy have improved both individually and kasial. The increase is seen from the percentage in cycle I of 53.4% increased in cycle II to 72.6%.Keyword: literacy, literary and sambel tukal stategiÂ