bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Novel Diagnostic and Prognostic Gene Signature Biomarkers for Breast Cancer Using Artificial Intelligence and Machine Learning Assisted Transcriptomics Analysis
Authors: Mirza Zeenat , Ansari Md Shahid , Iqbal Md Shahid , Ahmad Nesar , Alganmi Nofe , Banjar Haneen , Al-Qahtani Mohammed H. , Karim Sajjad 
Published: June 2023

Background: Breast cancer (BC) is one of the most common female cancers. Clinical and histopathological information is collectively used for diagnosis, but is often not precise. We applied machine learning (ML) methods to identify the valuable gene signature model based on differentially expressed genes (DEGs) for BC diagnosis and prognosis. Methods: A cohort of 701 samples from 11 GEO BC microarray datasets was used for the identification of significant DEGs. Seven ML methods, including RFECV-LR, RFECV-SVM, LR-L1, SVC-L1, RF, and Extra-Trees were applied for gene reduction and the construction of a diagnostic model for cancer classification. Kaplan–Meier survival analysis was performed for prognostic signature construction. The potential biomarkers were confirmed via qRT-PCR and validated by another set of ML methods including GBDT, XGBoost, AdaBoost, KNN, and MLP. Results: We identified 355 DEGs and predicted BC-associated pathways, including kinetochore metaphase signaling, PTEN, senescence, and phagosome-formation pathways. A hub of 28 DEGs and a novel diagnostic nine-gene signature (COL10A, S100P, ADAMTS5, WISP1, COMP, CXCL10, LYVE1, COL11A1, and INHBA) were identified using stringent filter conditions. Similarly, a novel prognostic model consisting of eight-gene signatures (CCNE2, NUSAP1, TPX2, S100P, ITM2A, LIFR, TNXA, and ZBTB16) was also identified using disease-free survival and overall survival analysis. Gene signatures were validated by another set of ML methods. Finally, qRT-PCR results confirmed the expression of the identified gene signatures in BC. Conclusion: The ML approach helped construct novel diagnostic and prognostic models based on the expression profiling of BC. The identified nine-gene signature and eight-gene signatures showed excellent potential in BC diagnosis and prognosis, respectively.
Determinants of forgiveness after experiencing infidelity in a marital relationship
Authors: Dacka Monika , Kulik Agnieszka , Nowak Katarzyna 
Published: June 2023

Marital infidelity, of whatever kind, causes serious conflicts in the relationship between spouses. Forgiveness is recognised as an important element in improving the relationship between spouses. It aids the conflict resolution process and increases commitment to the relationship. The aim of this study was to determine the determinants of forgiveness of infidelity in married people. A total of 373 people (339 women, 34 men), aged between 22 and 64 years, were studied. The study was conducted electronically using: Marital Forgiveness Scale (MOFS, Paleari, Regalia, Fincham, 2009; Polish adaptation Brudek, Steuden, 2015), Positivity Orientation Scale (Positivity Scale, Caprara et al., 2012; Polish adaptation Laguna, Oleś, Filipiuk, 2011), TIPI-PL (Ten Item Personality Inventory, Polish adaptation Sorokowska, Słotwińska, Zbieg, Sorokowski, 2014) and a personal questionnaire.
The correlational analyses conducted showed a positive relationship between relationship commitment, relationship fulfilment, positive orientation and emotional stability and forgiveness in the subjects. The higher the level of forgiveness, the higher the positive orientation. The relationship between personality traits and forgiveness in people experiencing betrayal was partially confirmed. A positive relationship was shown at a weak level between benevolence and agreeableness and a negative one with conscientiousness. Fulfilment and commitment were shown to be significant predictors of forgiveness. The relationship between commitment and forgiveness is moderated by the trait conscientiousness. The adopted pattern of variables explains respectively 17% of the variation in the results of the forgiveness variable.
Deux printemps et trente lunes
Authors: Lemus López Encarnación 
Published: June 2023

L’exil espagnol au Chili est généralement identifié avec l’expédition à bord du Winnipeg (le bateau des rouges, comme on disait alors) préparée par Pablo Neruda en 1939 ; mais l’exil espagnol au Chili est bien plus complexe : d’abord, il commence au début de la Guerre d’Espagne, de plus, il engendre de graves problèmes diplomatiques, au moins jusqu’à la fin de l’année 1940. Cet article analyse le refuge d’un petit groupe de républicains à l’ambassade du Chili à Madrid, à la fin de la guerre. Durant leur confinement, jusqu’à leur départ en exil – en octobre 1940 –, ils ont créé le magazine culturel Luna.
Exil, répression et mémoires, le triptyque des trajectoires chiliennes en France à partir du 11 septembre 1973
Authors: Prognon Nicolas 
Published: June 2023

Le renversement violent du gouvernement de l’Unité populaire de Salvador Allende le 11 septembre 1973 constitue une rupture dans l’histoire politique chilienne. Une chape de plomb tombe immédiatement sur le pays et la Junte entame une croisade pour sauver le pays au bord du chaos. Les violations systématiques des droits de l’Homme terrorisent la population et elles provoquent un exil massif. Immédiatement des milliers de Chiliens et étrangers réfugiés au Chili deviennent des cibles à éliminer. Ce coup d’État radiophonique, télévisuel, puis cinématographique, et sa couverture médiatique singulière, confère à ce flux d’exilés une connotation particulière qui se traduit, en France, par une solidarité exceptionnelle. Dans ce contexte, la France, à l’instar de quelques pays, va devenir une terre d’asile pour des milliers de Chiliennes et de Chiliens. L’apport de la mémoire des victimes complète le triptyque édifié à partir de 1973 dont les trois panneaux représentent chronologiquement la répression, l’exil et la mémoire.
نحو تنظيم قانوني لسحب الحكم القضائي في التشريع الأردني
Authors: الجراح د. جهاد , بني طه القاضي عثمان إبراهيم محمود , العكور د. عمر صالح علي 
Published: June 2023

تتمثل إشكالية الدراسة بأن المشرع الأردني لم ينظم نظرية سحب الحكم القضائي كنظرية عامة في قانون أصول المحاكمات المدنية من حيث شروطها وضوابطها وإجراءاتها والمحكمة المختصة بسحب الحكم والميعاد القانوني الذي يتوجب أن يقدم طلب السحب خلاله والأثار القانونية المترتبة على السحب وتوصلت الدراسة الى أنه يمكن تلمُّس الأساس التشريعي لها في المادة (204/2) من قانون أصول المحاكمات المدنية التي نصت على إحدى تطبيقات نظرية سحب الحكم وهو إعادة النظر بقرار محكمة التمييز أو القرار الصادر برفض منح الإذن شكلاً، وإن كان سحب الحكم أوسع مجالاً من إعادة النظر؛لأن إعادة النظر يقتصر على الأحكام الصادرة عن محكمة التمييز في حين أن سحب الحكم يمتد ليشمل الأحكام الصادرة عن محكمة الموضوع مثل محكمة البداية ومحكمة الاستئناف إذا كانت قطعية وغير قابلة للطعن إذا توافرت شروط سحب الحكم. كما وتوصلت الدراسة إلى أنه يوجد تطبيق آخر من تطبيقات نظرية سحب الحكم يتمثل بالمادة (133) من القانون نفسه التي نصت على بطلان الحكم القضائي وإمكانية إلغائه وإعادة النظر فيه في حال توافر إحدى حالات عدم صلاحية القضاة. في حين أن محكمة التمييز الأردنية، وكسابقة قضائية، قد أخذت بنظرية سحب الحكم القضائي ووضعت مجموعة من الشروط القانونية لذلك تتمثل بأن يكون الخطأ المبرر للسحب خطأ إجرائياً وليس موضوعياً وأن يكون مؤثر في النزاع وأن لا يتسبب فيه الخصوم وأن لا يكون هنالك وسيلة قانونية أخرى لتدارك هذا الخطأ. وقد أوصت الدراسة المشرع الأردني بتنظيم نظرية سحب الحكم القضائي ضمن قانون أصول المحاكمات المدنية كنظرية إجرائية عامة مُستحدثة وتقنينها ضمن نصوص قانونية تنظم شروطها وأحكامها القانونية وضوابطها وطرق السحب والأثار القانونية المترتبة عليها.
Typology of red maradi dairy goat farms in the north east of Benin
Authors: Lucrèce Marie Reine MEHOU-LOKO , Brice Gérard Comlan ASSOGBA , Maximilien AZALOU , TRAORE Ibrahim ALKOIRET 
Published: June 2023

1	ABSTRACT The characterization of livestock systems enables to identify the diversity of livestock farms in order to define development actions. The aim of this study is to characterize the different farming practices observed in the Red Maradi goat farms located in the North East of Benin. Data collection took place between August and December 2019, in 90 goat farms with at least one breeding nucleus of the Red Maradi breed. Using the Multiple Correspondence Factor Analysis (AFCM) and Ascending Hierarchical Classification (CAH) methods, a typology of Red Maradi goat farms in the region was developed. Thus, four types of breeding of Red Maradi goats were identified. Agro-pastoralists, traders (27.59%) and craftsmen (17.24%) mostly from the Bariba socio-cultural ethnic group (38.72%) characterize wandering peasant farms (type 1). They are responsible for herds of modest numbers (15 ± 8 heads) made up by purchase. The mode of rearing goat straying is practiced in 93.1% of these farms against 6.9% of semi-straying. The animals hardly have a sheepfold. The farms (type 2), semi-scavenging peasant herds, are mainly characterized by breeders and agro-breeders of the Fulani and Gando socio-cultural ethnic group (56%). They are responsible for small herds (16 ± 8 heads) and practice the seasonal straying of goats (88%). The animals are housed on these farms (58.07%) in a basic sheepfold and receive crop residues as a supplement. The breeders of type 3, semi-improved peasant breeding are from a very diverse socio-cultural ethnic group Dendi (23%), Yorouba (19%), Fon (11.5%), Bariba (12.5%) with a relatively higher level of education. Over 75% of type breeders have reached secondary level. They combine their main activity, public service, commerce and crafts, the breeding of goats with herds of relatively larger size (20 ± 15 heads). The animals are housed in more improved sheepfolds built in roughcast or hard earth and in 75% of these farms receive food and water in the pen. Type 4, semi-intensive dairy farming of Red Maradi goats, brings together farm farms producing and upgrading goat's milk. Fon (51.25%) and Bariba (48.75%) mostly own these farms. They are responsible for larger herds (57 ± 7 heads) so 35% is made up of the Red Maradi goat and the rest of the Saanen breed. The animals have a permanent sheepfold and, in addition to the basic ration consisting of fodder, a production supplement consisting of concentrate.
ANALISIS PENDAPATAN USAHA PENANGKARAN BENIH PADI DI DESA KARANG TUNGGAL KECAMATAN TENGGARONG SEBERANG KABUPATEN KUTAI KARTANEGARA (Analysis of Rice Seed Breeding Business Income in Karang Tunggal Village, Tenggarong Seberang District)
Authors: BEWTY SYSWY NUR , AIDA SYARIFAH , SURIAATMAJA MUHAMMAD ERWAN 
Published: June 2023

Seed breeding is an effort to produce superior seeds. Seeds play a big role in determining the success of crop production and productivity. One of the technological innovations that are expected to be introduced to improve paddy rice cultivation is the technology of breeding high-yielding varieties of rice seeds. The purpose of this study is to determine the production costs of rice seed breeding businesses, to determine the total receipts and income received, and to analyze the feasibility of rice seed breeding businesses in the Mekar Sari Seed Breeding Group, Karang Tunggal Village, Tenggarong Seberang District, Kutai Kartanegara Regency.The study was conducted from April to June 2022. The research location was determined intentionally (purposive) in the Mekar Sari Seed Breeding Group, Karang Tunggal Village, Tenggarong Seberang District, Kutai Kartanegara Regency. The data needed in this study are primary and secondary data. The method used in sampling is a saturated sampling method or census with a total of 15 respondents. The data analysis method used is the analysis of production costs, receipts, income, and R/C Ratio.The results showed that the rice seed breeding business in Karang Tunggal Village, Tenggarong Seberang District, obtained an average production cost of Rp. 9,408,574.76 mt⁻¹ with an average per hectare of Rp. 8,846,379.29 Ha⁻¹ mt⁻¹ average receipt of Rp. 25,360,000 mt ⁻¹ with an average per hectare of Rp. 23,520,000 Ha⁻¹ mt⁻¹ and an average income of Rp. 15,951,425.24 mt⁻¹ with an average per hectare of Rp. 14,673,620.71 Ha⁻¹ mt⁻¹.The result of the R/C Ratio analysis is 2.6. The R/C Ratio value shows that the rice seed business in the Mekar Sari Group is profitable and worth working on because of the R/C Ratio > 1.
PENGARUH TINGKAT PENDIDIKAN ORANG TUA, LINGKUNGAN SEKOLAH, SARANA & PRASARANA, DAN POLA ASUH ORANG TUA TERHADAP PRESTASI BELAJAR SISWA PADA SEKOLAH DASAR NEGERI SELAT BARU DI KABUPATEN BARITO SELATAN PROVINSI KALIMANTAN TENGAH
Authors: HANDAYU AGUNG 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui dan menganalisis variabel tingkat pendidikan orang tua, lingkungan sekolah, sarana & prasarana, dan pola asuh orang tua terhadap prestasi belajar siswa pada Sekolah Dasar Negeri Selat Baru di Kabupaten Barito Selatan Provinsi Kalimantan Tengah secara simultan, parsial dan dominan. Metode penelitian menekankan pada pembagian angket yang disebarkan kepada 32 responden yakni siswa Sekolah Dasar Negeri Selat Baru di Kabupaten Barito Selatan Provinsi Kalimantan Tengah. Teknik analisis data untuk mengetahui gambaran secara keseluruhan tentang pengaruh variabel bebas dan terikat dalam penelitian ini, maka dilakukan dengan uji instrumen, uji asumsi klasik dan analisis regresi linier berganda. Ketiga hipotesis dalam penelitian ini terbukti dan diterima bahwa variabel tingkat pendidikan orang tua, lingkungan sekolah, sarana & prasarana, dan pola asuh orang tua terdapat pengaruh baik secara simultan, parsial dan dominan terhadap prestasi belajar siswa pada Sekolah Dasar Negeri Selat Baru di Kabupaten Barito Selatan Provinsi Kalimantan Tengah.
Kata Kunci : Tingkat Pendidikan Orang Tua, Lingkungan Sekolah, Sarana & Prasarana, Pola Asuh Orang Tua, Prestasi Belajar Siswa
Influence of Electronic Use Media on Sleep Disturbance Severity among Adolescents
Authors: Abod Wafaa Salim , Obaid Khamees Bander 
Published: June 2023

Background: Adolescents' growth, cognitive development, learning, and general well-being are all affected by sleep, which is both a physiological phenomenon and a behavioral process. Adolescents' physiological and psychological development has a negative effect on their sleep, but it is also possible that access to electronic media and other outside variables like early school starts and the bedroom's surroundings also contribute to bad sleep.
Methodology: A descriptive design was used to guide this study. Data were collected for the period of October 10th, 2022, to December 20th, 2023. The study was carried out through different secondary schools in Holy Kerbala city to assess the effect of excessive use of electronic media on sleep disturbances among adolescents. The samples were selected non-randomly (a convenience sample) from separate areas of the center of Kerbala Holy Governorate, where the samples were chosen from the population only because they were available to the researcher. A sample of 382 total students was chosen to obtain the data. The sample of the study includes 139 females and 243 males.
Results : The study results reveal that the mean of hours students spend in internet is less than a half spend 2-5-hours in internet use (47.4%), followed by those who spend 6-10-hours in internet use (36.3%), those who spend 11-15-hours (9.2%), those who spend less than hour in internet use (5.8%), and those who spend 16-20 hours in electronic media use (1.3%). The study results reveal that the number of hours students spend on electronic media use every day and sleep hours positively predict excessive use of electronic media (p-value = .000, .024) respectively. The study results reveal that the sleep hours negatively predict sleep disturbance (p-value .004). On the other hand, excessive use of electronic media positively predict sleep disturbance (p-value = .000).
Conclusion : The majority of participants in the current study believe that sleep disturbances are strongly correlated with excessive use of electronic media and that the more excessive use of electronic media, the higher the incidence of sleep disturbances.
STRATEGI PENETAPAN HARGA OLEH PEDAGANG DI PASAR BATIK PAMEKASAN (kajian Undang-Undang Anti Monopoli dan Kompilasi Hukum Ekonomi Syariah)
Authors: Nisak Khoirun , Muqsith Abdurrahman 
Published: June 2023

Permaian penetapan harga dalam persaingan usaha selalu menjadi polemik bagi masyarakat termasuk pula di pasar batik pamekasan atau yang biasa dikenal dengan istilah p asar Bhere’ oleh masyarakat Pamekasan. Berangkat dari hal tersebut tujuan penelitian ini adalah mengkaji penetapan harga di pasar batik Pamekasan dengan menggunakan kajian Undang-Undang No.5 Tahun 1999 Anti Monopoli dan hukum ekonomi Syariah (KHES) dengan menggunakan penelitian empiris atau deskriptif kualitatif yang disesuaikan dengan fokus penelitian sehingga mengasilkan beberapa temuan sebagaimana berikut; (1) penetapkan harga batik di pasar batik Pamekasan jika dilihat dari perspektif UU Anti Monopoli telah melanggar Pasal 7 (tujuh) UU Anti Monopoli, indikasi pelanggaran tersebut terdapat pada cara penetapan harga di bawah harga pasar yang dilakukan oleh beberapa kelompok tertentu. Meskipun kesepatakan tersebut tidak secara tertulis namun adanya kata sepakat dalam menetapkan harga dibawah harga pasar, telah menjadi indikasi adanya perjanjian tidak tertulis yang jelas dilarang dalam Pasal 7 UU Anti Monopoli. (2) jika di tinjau dari perspektif hukum ekonomi Syariah, penetapan harga di pasar batik Pamekasan masih belum memenuhi kreteria-kreteria keislaman seperti kejujuran, keadilan, dan keterbukaan. Sehingga tujuan utama KHES guna dalam mencapai dalam jual beli dipasar batik Pamekasan belum terlaksanai dengan baik . Hal tersebut dikarenakan masih banyak ditemukan dari pedagang batik yang melakukan kecurangan dan bahkan kebohongan terhadap para konsumenya.
Metode K-Means Clustering Dalam Merancang Strategi Promosi Penerimaan Mahasiswa Baru Pada STIE Serelo Lahat
Authors: Farozi Mohamad 
Published: June 2023

New Student Admission at STIE Serelo Lahat is an annual activity carried out by STIE Serelo Lahat. A marketing strategy with several promotions is carried out as an initial activity to get new students. Marketing strategies are always evolving from year to year by analyzing student data from new student registrations to accepted students stated and used as the basis for analyzing targeted and accurate marketing strategies. Cluster formation is one of the techniques used in extracting the trend pattern of a data. K-Means Clustering is able to find and group data that has characteristics (similarities) between one data and other data and different data in different groups will show unstructured data groups becoming structured. This study applies the K-Means Clustering Method in designing a promotion strategy for new student admissions at STIE Serelo Lahat based on new student registration data analyzed by the clustering method using the K-Means algorithm so as to produce K-Means group information into three parts with variable values that different so that information is obtained that most of the choices of students in the Management Study Program originating from the Lahat District in Domination are from Private SMA / MA and from East Kikim District originating from Private Vocational Schools and the most registration is in the Second Wave. Furthermore, designing a marketing promotion strategy for New Student Admissions at STIE Serelo Lahat can be determined by using a minimal K-Means clustering approach. This approach makes it possible to have a great opportunity to increase the number of new students at STIE Serelo Lahat.Â Keyword : K-Means Clustering, Information, Students Admission
APLIKASI ISC (INFORMATICS STUDENT CENTER) MENGGUNAKAN METODE PERSONAL EXTREME PROGRAMMING BERBASIS ANDROID
Authors: Anjuliani Rizka , Astuti Lastri Widya , Hartini Hartini 
Published: June 2023

Gathering for informations today can be classified as a primary need. Various kinds of activities can be done using technology, especially smartphones, for example, learning, interacting with other people, searching for information, or just for entertainment. There are many kinds of activities and Â many variety to access them. So it cannot be done all at once in a practical way, we need a solution to be able to carry out these activities at once with easy access. The above issue is one of the problems which is faced by the University of Indo Global Mandiri (UIGM). In order for learning and getting information can be done at once and easily accessible, then the researcher do research that aims to build applicationsÂ Informatics Student Center Â (ISC) which is developed by using the Personal Extreme Programming (PXP) consisting of several phases, such as requirements, planning, iteration initialization, design, implementation, and system testing. ISC applications using the Android operating system, built with the collaboration of the Java language, PHP, and MySQL database. In addition to ease of access, the ISC has some features that academic information, discussion forums, entertainment, and job opportunity. Based on test results, it was concluded that the ISC application can run on Android mobile devices which are tested. Result from this study is the availability of applications supporting learning activities and access information that can be accessed online through the Android mobile devices
ESTIMASI PENGUNJUNG MENGGUNAKANSIMULASI MONTE CARLO PADA WARUNG INTERNET XYZ
Authors: Irfani M. Haviz , Dafid Dafid 
Published: June 2023

Monte Carlo is a simulation method that using random numbers obtained from Linear Congruential Generator (multiplicative generator) as an approximation in estimating the number of visitors using previous time visitor data. The number of visitors who come to use internet services on internet cafes is often difficult to predict. Apart from some indicators that affect or may be experienced by the cafe owner with the activities of the internet service, it willÂ predicted the number of visitors using visitor data from 60 days ago with linear method congruential generator as scrambler and monte carlo method as estimator. The results obtained is the estimated number of visitor in uniform distribution [0,1] for the next 60 days that can be used as information for cafe owner.Keywords:Simulasi, Linier Congruential Generator, Monte Carlo, Estimasi, Random Number
OPTIMASI WAKTU QUERY DAN FILTERING NAMA DOMAIN PADA DNS SERVER LOKAL MENGGUNAKAN BIND 9
Authors: Novianto Dian 
Published: June 2023

DNS is made to facilitate users in accessing a website with a domain without having to continually update the files host.txt.DNS was developed in 1983, every user accessing a website using a domain name through a browser, will be routed by the router to a public DNS serverto get a web address in the form of ip address.It takes time for DNS servers to reverse and lookup for translate domain names into ip addresses and vice versa.By creating a local DNS server as a cache,then it can be applied forwarding technique on DNS Server,so the time required to find the web server address of a destination website becomes faster. In addition to minimizing query time by implementing a local DNS server, can also be filtered against a particular domain name even though using a secure protocol like httpsby creating a zone for the web address you want to filter. So the use of the Internet becomes more useful. In this study the software used linux debian 8 as the operating system, and BIND9 as the software that runs the function of DNS Server.Keywords:Forwarding DNS,BIND 9, Debian 8Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â