bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy comparison of vascularized iliac crest bone flap and Ilizarov bone transport in the treatment of traumatic bone defects of the tibia combined with large soft tissue defects
Authors: Cao Zhe-ming , Sui Xin-lei , Xiao Yu , Qing Li-ming , Wu Pan-feng , Tang Ju-yu 
Published: May 2023

Abstract
Background
Traumatic tibial defect complicated with soft tissue defect is a difficult problem in clinic. Vascularized iliac crest bone flap (VIBF) and Ilizarov bone transport are effective methods to treat tibial defects with limited defect length, which most need to be explored accordingly.

Methods
In this study, a total of 68 patients with traumatic tibial defect (ranging from 4 to 10 cm) and large soft tissue defect were collected retrospectively. The soft tissue defects were repaired by latissimus dorsal musculocutaneous flap (LD), anterolateral thigh flap (ALTF) or both. Thirty-three cases were treated with vascularized iliac crest bone flap transplantation and 35 cases were treated with Ilizarov bone transport. Intraoperative and postoperative follow-up data (including operation time, blood loss, bone union time, external fixation time, external fixation index, complication rate, reoperation rate, and functional evaluation) were recorded, and comparative analysis was performed.

Results
The median follow-up time was 32 months. Compared with Ilizarov group, the VIBF group exhibited statistically faster bone union time (6.3 ± 1.0 vs. 18.2 ± 3.0 months). Moreover, the VIBF group showed shorter EFT (7.3 ± 1.0 vs. 19.2 ± 3.0 months) and a better EFI (34.8 ± 9.2 vs. 84.2 ± 23.7 days/cm). The excellent and good rate of lower limb appearance evaluation in VIBP group was significantly better than that in Ilizarov group. The complication rate and reoperation rate were significantly higher in Ilizarov group.

Conclusion
In summary, compared with Ilizarov bone transport, VIBP has the advantages of faster healing, shorter external fixation time, lower complication and reoperation rate, and better appearance within the limited defect length. Ilizarov bone transport is still preferred when the defect length exceeds the maximum repair length of the iliac flap. The daily handling required by bone transport process is painful.

Level of evidence
III, Case–control study.
Bushen-Yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via AMPK/Sirt1 signaling pathway in D-gal-induced aging rats
Authors: Liao Yanfang , Lai Yiyi , Xu Huilin , Gao Li , Fu Xiaomei , Wang Xue , Wang Qi , Shen Jiangang , Fang Jiansong , Fang Shuhuan 
Published: May 2023

Abstract
Background
As a major risk factor for neurodegenerative diseases, aging has become a heavy health care burden worldwide. Age-related decline in mitochondrial function and oxidative stress is strongly associated with neurodegeneration. The previous study demonstrated that Bushen-Yizhi formula (BSYZ), a traditional Chinese medicine formula, is effective in reducing neurodegeneration.

Methods
This study is the first to investigate the effect of BSYZ on D-gal-induced learning memory in rats. Secondly, the potential metabolic mechanism of BSYZ was explored by 1H-NMR metabolomics analysis. Then based on the comparison of differential metabolites implied that BSYZ ameliorated mitochondrial dysfunction through choline metabolic pathway in D-gal-treated rats. Finally, pharmacological validation was conducted to explore the effects of BSYZ on D-gal-induced oxidative stress, neuroinflammation, and neuronal apoptosis.

Results
Our data showed that BSYZ increased aspartate and betaine levels, while decreasing choline levels. Furthermore, BSYZ also increased the proteins level of CHDH and BHMT to regulate choline metabolic pathway. Meanwhile, BSYZ alleviated mitochondrial damage and oxidative stress, including enhanced ATP production and the ratio of NAD+/NADH, reduced the level of MDA, enhanced GSH and SOD activity, upregulated the expressions of p-AMPK, SIRT1 proteins. In addition, BSYZ downregulated the levels of inflammatory cytokines, such as TNF-α, IL-1β and IL-6, as well as suppressed Bcl-2 proteins family dependent apoptosis.

Conclusion
BSYZ treatment effectively rescues neurobehavioral impairment by improving mitochondrial dysfunction, oxidative stress, neuroinflammation and neuroapoptosis via AMPK/SIRT1 pathway in D-gal-induced aging.
IMPOWER: a national patient-generated registry for intestinal malrotation exploring diagnosis, treatment, and surgical outcomes
Authors: Martinez Sydney A. , Fligor Scott C. , Tsikis Savas , Short Meagan , Corcoran Katie E. , Rogers Amy , Gura Kathleen M. , Puder Mark 
Published: May 2023

AbstractBackgroundIntestinal malrotation is a rare congenital condition with potentially devastating consequences due to potential volvulus and massive intestinal necrosis. Diagnosis is often delayed and long-term symptoms following surgical correction are poorly characterized. We developed theIntestinal Malrotation Patient Outcomes and WEllness Registry (IMPOWER), a national patient-generated registry (PGR), to capture data related to presenting symptoms, testing, diagnosis, treatment, and follow-up of individuals diagnosed with malrotation. IMPOWER captures patient-reported information from adult patients and parents/caregivers of children diagnosed with malrotation at the time of enrollment and at ongoing 6-month intervals. We present baseline characteristics of patients enrolled during the first two months of the registry.ResultsWithin the first two months, 354 patients with malrotation enrolled in IMPOWER, and 191 (53.9%) completed all baseline assessments. Nearly 90% of the 119 pediatric participants and 37.7% of the 72 adult participants experienced symptoms prior to diagnosis. Vomiting was the predominant symptom for pediatric participants compared to abdominal pain in adults. Yellow bilious emesis was more commonly reported than green, and volvulus at diagnosis occurred in 70% of pediatric and 27% of adult participants. One-third of pediatric participants had a bowel resection as part of their initial surgical procedure, resulting in 23.4% with diagnosed short bowel syndrome. More than 60% of pediatric and 80% of adult registrants reported gastrointestinal symptoms that persisted throughout the first year following their initial operation. Approximately 25% of registrants reported visiting four or more gastroenterologists for management of ongoing symptoms.ConclusionsFewer than half of pediatric patients presented with the “classic” presentation of green bilious colored emesis. Yellow bilious emesis was more commonly reported, and chronic gastrointestinal symptoms (i.e., abdominal pain, reflux, constipation, diarrhea) and feeding intolerance were common following surgical procedures for malrotation. This novel PGR highlights the need for a multicenter prospective registry to characterize the natural history and develop consistent standards of care related to the diagnosis, treatment, and long-term care for patients with malrotation.
The effectiveness of a computer-aided system in improving the detection rate of gastric neoplasm and early gastric cancer: study protocol for a multi-centre, randomized controlled trial
Authors: Dong Zehua , Zhu Yijie , Du Hongliu , Wang Junxiao , Zeng Xiaoquan , Tao Xiao , Yang Ting , Wang Jiamin , Deng Mei , Liu Jun , Wu Lianlian , Yu Honggang 
Published: May 2023

Abstract
Background
This protocol is for a multi-centre randomised controlled trial to determine whether the computer-aided system ENDOANGEL-GC improves the detection rates of gastric neoplasms and early gastric cancer (EGC) in routine oesophagogastroduodenoscopy (EGD).

Methods
Study design: Prospective, single-blind, parallel-group, multi-centre randomised controlled trial.
Settings: The computer-aided system ENDOANGEL-GC was used to monitor blind spots, detect gastric abnormalities, and identify gastric neoplasms during EGD.
Participants: Adults who underwent screening, diagnosis, or surveillance EGD.
Randomisation groups:

1. Experiment group, EGD examinations with the assistance of the ENDOANGEL-GC;
2. Control group, EGD examinations without the assistance of the ENDOANGEL-GC.
Randomisation: Block randomisation, stratified by centre.
Primary outcomes: Detection rates of gastric neoplasms and EGC.
Secondary outcomes: Detection rate of premalignant gastric lesions, biopsy rate, observation time, and number of blind spots on EGD.
Blinding: Outcomes are undertaken by blinded assessors.
Sample size: Based on the previously published findings and our pilot study, the detection rate of gastric neoplasms in the control group is estimated to be 2.5%, and that of the experimental group is expected to be 4.0%. With a two-sided α level of 0.05 and power of 80%, allowing for a 10% drop-out rate, the sample size is calculated as 4858. The detection rate of EGC in the control group is estimated to be 20%, and that of the experiment group is expected to be 35%. With a two-sided α level of 0.05 and power of 80%, a total of 270 cases of gastric cancer are needed. Assuming the proportion of gastric cancer to be 1% in patients undergoing EGD and allowing for a 10% dropout rate, the sample size is calculated as 30,000. Considering the larger sample size calculated from the two primary endpoints, the required sample size is determined to be 30,000.

Discussion
The results of this trial will help determine the effectiveness of the ENDOANGEL-GC in clinical settings.

Trial registration
ChiCTR (Chinese Clinical Trial Registry), ChiCTR2100054449, registered 17 December 2021.
Template-assisted synthesis of molecularly imprinted polymers for the removal of methyl red from aqueous media
Authors: Shafqat Syed Rizwan , Bhawani Showkat Ahmad , Bakhtiar Salma , Ibrahim Mohamad Nasir Mohamad , Shafqat Syed Salman 
Published: May 2023

AbstractThis study entails the synthesis of molecularly imprinted polymers (MIPs) with good selectivity coefficients for azo dye as a potential sorbent material to extract azo dye from polluted aqueous media. A series of MIPs for methyl red (MR) as a template, were synthesized by changing the molar ratio of functional monomers, via precipitation polymerization format of non-covalent approach. Water-soluble functional monomer; acrylic acid (AA) was used to weave the frame work of polymers while ethylene glycol dimethacrylate (EGDMA) was utilized as crosslinking monomer. The impact of different experimental parameters, such as mole ratio of monomer (functional) to crosslinking monomer on the molecular recognition was investigated. The highly efficient and selective MR-MIP was used for the removal of spiked MR dye from different water samples. The selected imprinted polymer, MR1-MIP was able to selectively remove the MR molecules from aqueous media. A significant amount of dye was removed by MR1-MIP from the river water samples with a high degree of removal efficiency i.e. 92.25%. The imprinting factor of 3.75 for MR1-MIP indicated that the high selectivity in terms of adsorption for MR. A minimum loss of only ~ 3.35% in the removal efficiency within ten sequential cycles of adsorption–desorption study evidenced that MR-MIPs could be used as the most cost effective and best sorbent for the removal of MR from polluted water. Furthermore, the structural properties of MR-MIPs were characterized by FTIR and EDX, whereas TGA, SEM and BET were used to describe the thermal, morphological and surface structures of the particles, respectively.
Graphical Abstract
Orbital b-metric spaces and related fixed point results on advanced Nashine–Wardowski–Feng–Liu type contractions with applications
Authors: Rasham Tahair , Shabbir Muhammad Sajjad , Nazam Muhammad , Musatafa Arjumand , Park Choonkil 
Published: May 2023

AbstractIn this article, we prove some novel fixed-point results for a pair of multivalued dominated mappings obeying a new generalized Nashine–Wardowski–Feng–Liu-type contraction for orbitally lower semi-continuous functions in a complete orbital b-metric space. Furthermore, some new fixed-point theorems for dominated multivalued mappings are established in the scenario of ordered complete orbital b-metric spaces. Some examples are offered to demonstrate the validity of our new results’ premise. To demonstrate the applicability of our findings, applications for a system of nonlinear Volterra-type integral equations and fractional differential equations are shown. These results extend the theoretical results of Nashine et al. (Nonlinear Anal., Model. Control 26(3):522–533, 2021).
Task offloading optimization mechanism based on deep neural network in edge-cloud environment
Authors: Meng Lingkang , Wang Yingjie , Wang Haipeng , Tong Xiangrong , Sun Zice , Cai Zhipeng 
Published: May 2023

AbstractWith the rise of edge computing technology and the development of intelligent mobile devices, task offloading in the edge-cloud environment has become a research hotspot. Task offloading is also a key research issue in Mobile CrowdSourcing (MCS), where crowd workers collect sensed data through smart devices they carry and offload to edge-cloud servers or perform computing tasks locally. Current researches mainly focus on reducing resource consumption in edge-cloud servers, but fails to consider the conflict between resource consumption and service quality. Therefore, this paper considers the learning generation offloading strategy among multiple Deep Neural Network(DNN), proposed a Deep Neural Network-based Task Offloading Optimization (DTOO) algorithm to obtain an approximate optimal task offloading strategy in the edge-cloud servers to solve the conflict between resource consumption and service quality. In addition, a stack-based offloading strategy is researched. The resource sorting method allocates computing resources reasonably, thereby reducing the probability of task failure. Compared with the existing algorithms, the DTOO algorithm could balance the conflict between resource consumption and service quality in traditional edge-cloud applications on the premise of ensuring a higher task completion rate.
Effects of amendments on carbon and nitrogen fractions in agricultural soils of Yellow River Delta
Authors: Wu Lipeng , Zhang Kaijing , Zhu Xingyu , Lu Tongping , Wang Xiujun 
Published: May 2023

AbstractAlthough various measurements (including organic amendments) have been used to ameliorate saline–alkaline soils, soil organic matter (SOM) remains low in most salt-affected agriculture soils. It was hypothesized that lower SOM level was partly attributable to weaker SOM stability (thus greater desorption) in the salt-affected soils. To test this hypothesis, we conducted a 16-week incubation experiment using low- and high-salinity soils to evaluate the effects of soil ameliorants (gypsum, CaCO3, rice straw and biochar) on SOM labile fractions, i.e., water extractable organic carbon (WEOC) and nitrogen (WEON), together with microbial biomass carbon (MBC) and nitrogen (MBN). Our results showed an increase in MBC and MBN under all amendments in both low- and high-salinity soils, reflecting improvements in soil properties. Gypsum amendment led to a decrease in both WEOC (by 15–21%) and WEON (by 14–31%). CaCO3 amendment only caused a decrease in WEON (by 14–27%), with a greater decrease found in the high-salinity soil. There was an increase in WEOC (by 13–66%) but a decrease in WEON (7.6–46%) under biochar and straw amendments in both low- and high-salinity soils. WEOC:SOC ratio (an indicator for SOC desorption) showed a decrease under gypsum and biochar amendments but an increase with CaCO3 and straw treatments. There was a decrease in WEON:TN ratio (an indicator for ON desorption) under all amendments, with the greatest decrease under biochar treatment. Our analyses demonstrated an enhancement in SOC or ON adsorption under all amendments, indicating that SOM stability might be enhanced in association with soil amelioration. Our study also highlights that there is strong decoupling between carbon and nitrogen cycles and further studies are needed to examine the impacts of such decoupling on SOM stability.
Gastric tumor mimicking bronchial tissue associated with a laryngotracheoesophageal cleft: a case report
Authors: Nakatani Erika , Terui Keita , Nakata Mitsuyuki , Komatsu Shugo , Shibata Ryohei , Oita Satoru , Kawaguchi Yunosuke , Takenouchi Ayako , Harada-Kagitani Sakurako , Kishimoto Takashi , Fukumoto Koji , Hishiki Tomoro 
Published: May 2023

Abstract
Background
Laryngotracheoesophageal cleft (LTEC) is a rare disease in which the larynx and trachea communicate posteriorly to the esophagus. It is often associated with other congenital malformations, particularly gastrointestinal anomalies. Herein, we report a case of LTEC associated with a gastric polypoid lesion in bronchial tissue.

Case presentation
A gastric mass was detected in a male fetus since week 21 of gestation using fetal ultrasonography. Esophagogastroduodenoscopy performed after birth revealed a pedunculated polypoid lesion of the gastric fornix. The patient experienced frequent vomiting and aspiration pneumonia, which persisted after nasoduodenal tube feeding. Communication between the airway and esophagus was suspected. Laryngoscopy performed 30 days later revealed an LTEC (type III). Partial gastrectomy was performed when the patient was 93 days of age. Histopathological examination revealed tumor consisting of cartilage tissue covered with a layer of respiratory epithelium.

Conclusion
The gastric tumor associated with LTEC exhibited structures mimicking bronchial tissue. LTEC occurs because of foregut maldevelopment, and the tumorous respiratory tissue in the stomach may have been formed from the same abnormal foregut development event as LTEC.
Research evidence and implementation gaps in the engagement of people with lived experience in mental health and substance use research: a scoping review
Authors: Hawke Lisa D. , Sheikhan Natasha Y. , Roberts Sara , McKee Shelby 
Published: May 2023

Abstract
Background
There is growing recognition that engaging people with lived experience (PWLE) in mental health and substance use research improves the quality of the research in terms of relevance to the population and the feasibility of the work. Engagement also provides positive opportunities for research teams and the PWLE engaged. However, there are many gaps in the research on PWLE engagement. This scoping review synthesizes the gaps in the implementation of PWLE engagement and in the research on engagement as presented by research teams engaging PWLE in their work.

Method
A systematic electronic database search was conducted in 2022 for published articles on PWLE engagement in mental health and substance use research. Potential articles were screened for relevance. The search led to 49 final articles included in the review. The 49 articles were then coded using codebook thematic analysis to answer two research questions: (1) What are the research evidence gaps regarding the engagement of PWLE in mental health and substance use research?; and (2) What are the gaps in implementing PWLE engagement in mental health and substance use research? PWLE were engaged in the conduct of this review.

Results
Results showed that research evidence gaps include further work on conceptualizing engagement; developing resources, tools, and practice recommendations to support research teams; increasing diversity in evaluations of engagement; and evaluating engagement, including its impact on the research, on PWLE, and on researchers. Implementation gaps included several broader institutional gaps and gaps in the day-to-day practice of engagement.

Conclusions
Despite progress in PWLE engagement in mental health and substance use research in recent years, research evidence and implementation gaps remain. Research teams are encouraged to consider these gaps and conduct research and implementation activities to address them in a rigorous manner.
Delayed emergence from anesthesia caused by an intraoperative cerebral embolism of a malignant peripheral nerve sheath tumor in a neurofibromatosis type 1 patient: a case report
Authors: Kawano Keishi , Tani Makiko , Morimatsu Hiroshi 
Published: May 2023

Abstract
Background
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas which commonly arise from neurofibromatosis type 1. Lung metastases of the tumors are well-known, but intraoperative cerebral tumor embolisms of MPNSTs have not been reported in literature.

Case presentation
A 52-year-old female patient with neurofibromatosis type 1 underwent a right lung partial resection for lung tumors. She was extubated after adequate recovery of spontaneous breathing; however, she could not respond to verbal commands. In the intensive care unit, her neurological examination revealed conjugate eye deviation, right hemiparalysis, and aphasia. Magnetic resonance imaging revealed acute cerebral ischemia, so she underwent an endovascular thrombectomy. The histopathological diagnosis of emboli was a MPNST, which was identical with that of the resected lung tumor.

Conclusion
We report the first case of delayed emergence caused by a cerebral tumor embolism of MPNST during partial lung resection.
Physiological and productivity responses of fenugreek to foliar spraying with molybdenum and cysteine
Authors: Khater Mahmoud Ahmed , Wahed Mohamed Salama Abd El , Salama Dina Mohamed 
Published: May 2023

Abstract
Background
Fenugreek (Trigonella foenum-graecum L.) is one of the oldest cultivated medicinal plants, as well as it is rich with medicinal antioxidant components. The effect of foliar spraying with molybdenum, cysteine on growth, quality and productivity of fenugreek was evaluated in a conducted greenhouse experiment during 2019/2020 and 2020/2021 growing seasons.

Results
Results showed that there were different effects of molybdenum, cysteine and their interaction on morphological characters, photosynthetic pigments, seed yield and yield components and some chemical components of fenugreek plants. However, there was a variety of polypeptide bands with different molecular weights ranging from 18.94 to 250 kDa and was detected with polymorphic ratio 61.91%. Moreover, multiple bands varied in their molecular weight were detected in all tested plants using ISSR primers. The polymorphic percentage reached 70.00, 73.33, 76.19, 72.22, 77.77 and 70.59% in all tested plants with primer IS-01, Is-02, IS-03, IS-04, Is-05 and IS-06, respectively.

Conclusions
It was cleared that foliar spraying with molybdenum, cysteine and their interaction enhanced and improved growth, quality and productive characters of fenugreek. Moreover, there were molecular changes in fenugreek under study and generated bands using the six ISSR primers.