bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Approach to Acute SARS-CoV-2 Management with Complementary Neuraltherapeutic Medicine: A Case Report
Authors: Bustamante Carlos , Pinilla Laura , Amaris Oscar 
Published: April 2023

Background: It has been proposed that the immunomodulatory capacity of neuraltherapeutic medicine (NTM) functions by means of stimuli to the nervous system, which influences the self-regulatory and plastic capacity of the nervous system, especially through the autonomic balance between the sympathetic and parasympathetic nervous systems. Several studies report the usefulness of NTM in inflammatory pathologies. Case presentation: A case report through a retrospective review of the medical history of an 82-year-old male patient with a diagnosis of acute SARS-CoV-2 who received a therapeutic intervention of NTM at the beginning of his hospitalization and presented satisfactory clinical evolution, with a follow-up for 18 months without post-COVID sequelae. A patient diagnosed with acute pneumonia for SARS-CoV-2, and mild ARDS, with markers of severity given by the history of COPD, advanced age, and elevation of LDH, ferritin, and CRP. On the third day of hospitalization, he presented an episode of pulmonary thromboembolism. He presented significant clinical improvement with in-hospital management for 9 days and underwent out-patient control with no post-COVID sequelae. Conclusions: NTM could be useful for the management of acute inflammatory diseases, including viral diseases such as SARS-CoV-2, in a mild or severe state of inflammation, when added to allopathic medicine, and it can improve clinical evolution and long-term sequelae. More studies are needed to validate this information.
Mechanical thrombectomy with Q catheter in stroke caused by primary and secondary distal and medium vessel occlusions
Authors: Kobeissi Hassan , Ghozy Sherief , Flood Richard , Mortimer Alex , Crossley Robert , Cox Anthony , Minks David , Wareham James 
Published: April 2023

Background The MIVI Q aspiration catheters have been shown to achieve significantly greater flow rates than other intracranial aspiration catheters in vitro. We describe our initial real-world experience with the MIVI Q catheter in emergent acute ischemic stroke (AIS) caused by distal and medium vessel occlusions (DMVO). Methods Data was collated from a prospectively maintained database which included patients from October 2019 to December 2022. Occlusion demographics, thrombectomy technique, reperfusion scoring, procedural complications and disposition were assessed. The primary outcome of interest was rate of successful reperfusion defined as thrombolysis in cerebral infarction (TICI) score 2b-3. Secondary outcomes included rate of first pass effect (FPE) and complications. Results We included 64 target occlusions in 51 patients. The Q catheter successfully reached the DMVO in all occlusions. Successful reperfusion was achieved in 49/64 (76.6%) occlusions, and TICI scores were similar for primary and secondary DMVOs (P value = 0.41). FPE was achieved in 39/64 (60.9%) occlusions and did not differ between primary and secondary DMVOs (P value = 0.13). Reperfusion hemorrhage occurred in 3/64 (4.7%) cases, small volume subarachnoid hemorrhage in 3/64 (4.7%) cases, and small hemorrhagic transformation in 1/64 (1.6%) cases; the rate of complications did not differ based on primary versus secondary DMVO (P value = 0.29). Conclusion The MIVI Q catheter is both safe and effective. Our real-world experience supports the superior flow rates demonstrated in vitro and translates into high rates of successful reperfusion in AIS caused by DMVO in clinical practice.
Knowledge of arteriovenous fistula care in patients with end-stage kidney disease in south Asian countries: A systematic review and meta-analysis
Authors: Natti Krishna Veena , Tiwary Bhaskar , Nayak Megha Nagaraj , Patel Nikita , Gandhi Priyaj , Majumdar Piyusha 
Published: April 2023

Objectives To find the prevalence of knowledge of arteriovenous fistula (AVF) self-care, its characteristics, and associated factors among hemodialysis patients and summarize the findings of various domains of AVF self-care in south Asian countries. Methods The systematic literature search was performed on online databases and additional sources to retrieve published articles on AVF self-care. We estimated the pooled prevalence using a random effects model in meta-analysis. Additionally, thematic knowledge regarding various aspects of AVF self-care was narratively summarized. Results Among the articles retrieved seven studies met our inclusion and exclusion criteria. The prevalence of AVF self-care in individual studies ranged from 59% to 99%, with an overall random pooled prevalence of 81% (95% CI, 68% to 94%). Major factors associated with self-care of AVF knowledge included patients’ educational status, age, vintage of hemodialysis, and healthcare personnel’s advice. Discussion Knowledge scarcity regarding potential measures of AVF self-care obligates the need for continuous education in hemodialysis patients. A multidisciplinary approach is vital to enhance self-care from pre- to post-creation of AVF in hemodialysis patients as well as their caregivers in order to prolong the patency rates and decrease the subsequent morbidity and mortality due to failure of AVF.
The Variable Impact of Clinical Risk-Adjustment Models to Evaluate Hospital Design
Authors: Mead Mitchell , Nanda Upali , Ibrahim Andrew M. 
Published: April 2023

Objectives: To identify the impact of clinical risk adjustment models for evaluating pain medication consumption differences between private rooms and a multibed ward. Background: Views of nature are reported to reduce anxiety and pain for patients. This often leads to prioritizing large windows with views for patient rooms; however, it is not clear how other factors influencing pain (e.g., patient demographics) may confound evaluations of room design. Methods: We identified 1,284 patients at the University of Michigan undergoing thyroidectomy where patients recovered in one of the two locations: a private room with a view to nature or a multibed ward with no windows. We used pain medication data from the electronic medical record and risk adjustment models to evaluate pain medication consumption between the room types. Results: Private room patients did not use more pain medications when measured using unadjusted morphine milligram equivalents (18.3 vs. 15.3 mg, p = .06). Risk adjusting for age, gender, comorbidities, opioid history, and procedure subtype resulted in private room patients demonstrating higher consumption of morphine milliequivalents (17.5 vs. 15.5 mg, p < .01). In contrast, risk adjusting for age, gender, opioid history, and selected comorbidities estimated higher pain medication consumption for multibed ward patients relative to private rooms (16.27 vs. 15.51 mg, p < .05). Conclusion: Estimated differences of pain medication consumption for patients in differently designed rooms varied depending on the risk adjustment model. These findings underscore the importance of understanding appropriate clinical measurement and risk adjustment strategies to accurately estimate the impact of design, before applying research into practice.
Background Music’s Impact on Patients Waiting in Surgery and Radiology Clinics
Authors: Yeoh Joanne Pei Sze , Spence Charles 
Published: April 2023

Objectives: To assess the impact of different types of background music on patients’ anxiety and perceptions in a healthcare setting. Background: An overwhelming number of studies in the West have been conducted on the use of background music in reducing patients’ anxiety and their perception of hospitals. Despite the optimism for Western classical music in such settings, evidence documenting the successful use of this genre of music in waiting rooms across other people groups has, thus far, been inconclusive. Method: A single-blind randomized study in which a total of 303 participants were recruited from both surgery and radiology clinics using a between-groups experimental design. Patients were seated in the waiting room for at least 20 min while music (Western classical, lo-fi) or no music was playing in the background. Participants were then required to complete a questionnaire that consisted of a shortened 6-item State Trait Anxiety Inventory (STAI-6), and eight questions relating to overall perceptions of the hospital. Results: The results from both clinics revealed that patients in the no music condition rated themselves as feeling significantly less anxious than those in either of the two music conditions. Patients’ perceptions of the hospital’s overall service and expectations were higher in the no music condition. Conclusions: Firstly, the choice of background music should match the differing pace of the day; for example, a more upbeat song would better fit the mood of a busy clinic, leading to a more “congruent” atmosphere. Secondly, playing background music in a “task-oriented” and highly charged/anxious environment may increase arousal levels, which in turn could result in negative perceptions of the hospital and an increase in anxiety among patients. Finally, music is a cultural product and music that primes certain beliefs in one culture may not have similar effects among other people groups. Hence, specific curated playlists are necessary to convey “intentions” to different people groups.
Reconstructing Historical Distribution of Large Mammals and their Habitat to Inform Rewilding and Restoration in Central Tanzania
Authors: Athumani Paulo C. , Munishi Linus K. , Ngondya Issakwisa B. 
Published: April 2023

Backgroundand research aim: In the anthropogenic landscapes where historically wildlife existed, there can be a potential for rewilding to reverse extinction. However, there is limited literature providing approaches to achieve successful rewilding. The current study aimed at providing empirical based methodological procedures for successful rewilding of the University of Dodoma (UDOM) and nearby degraded landscape by assessing past and current vegetation and large mammal species’ occurrence. Methodology: The past occurrence of mega-herbivores and their habitat was assessed using systematic literature survey, past vegetation maps and key informant interviews. EBSCOhost database and Google Scholar search engine were used for literature searching. A survey was conducted at UDOM area which is one of the remaining habitat patches in central Tanzania to examine present plant diversity. Results: The baseline vegetation map of 1960 indicated that the study area was mainly Savanna woodland. Literature suggested that anthropogenic activities resulted into Land-Use Land-Cover Changes (LULCC) leading into wild animals’ extirpation leaving remnant populations in the surrounding protected areas. While the key informant interviews verified local loss of mega-herbivores, field data collected at UDOM campus in 2022 indicated the vegetation transformation to bushland dominated by Dichrostachys cinerea. The area’s past vegetation composition was 33% grasses, 29% herbs, 21% shrubs and 17% trees while the current was 18% grasses, 42% herbs, 30% shrubs and 10% trees. Conclusion: The study revealed that central Tanzania hosted spectacular large mammal populations that interacted with the savanna which has recently been transformed to bushland. However, observed evidence on past existence of large mammals and recent elephants’ sightings at UDOM area indicate great potential for rewilding. Implication for conservation: Reconstructing historical information of ecosystems is crucial for successful rewilding. Such information can guide conservation efforts aiming at reversing extinction and reestablishing connectivity of large herbivore population across ecosystems.
Secondary haemophagocytic lymphohistiocytosis vs methotrexate toxicity – a diagnostic conundrum
Authors: Hawkins Leah , Gibbs Jack , MacMillan Connor 
Published: April 2023

Summary A 74-year-old female with a background of rheumatoid arthritis, managed with weekly methotrexate, was admitted with; oedema, dyspnoea, cachexia and jaundice. Bloods revealed pancytopenia, hyperferritinaemia, hyperbilirubinaemia, hypoalbuminaemia and hypofolataemia. Imaging showed a large right-sided pleural effusion, requiring therapeutic aspiration, and splenomegaly. Bone marrow aspirate revealed haemophagocytosis. Differential diagnoses included methotrexate toxicity (MTXT) and haemophagocytic lymphohistiocytosis (HLH). Management was initiated for MTXT whilst ongoing investigation for possible HLH continued.
Diagnosis of struma peritonei 15 years after rupture of mature teratoma
Authors: Griffin Julia , Abdulrahim Ahmed , Elger Breanna , Sharma Poonam , Hilgers Teresa 
Published: April 2023

Background: Struma peritonei is an extremely rare presentation of struma ovarii. Case: Here we report the case of a 38-year-old woman with a history of papillary thyroid cancer, left ovary struma ovarii, ruptured mature cystic teratoma of the right ovary, and endometriosis presenting with pelvic pain, dysmenorrhea, abnormal uterine bleeding, and infertility. A diagnostic laparoscopy was performed to evaluate for recurrence of endometriosis. However, multiple abnormal appearing lesions were found on her left hemidiaphragm and left abdominal wall. The tissue was identified as ectopic thyroid tissue identical to the patients ruptured mature cystic teratoma which occurred 15 years prior. A second subsequent laparoscopy was performed to excise the lesions. Eleven additional lesions were identified as ectopic thyroid tissue. This peritoneal dissemination was likely a result of tissue seeding post-mature teratoma rupture. Conclusion: Gynecologists should consider the possibility of struma peritonei in patients who have a history of papillary thyroid cancer and struma ovarii who present with significant pelvic pain and abnormal uterine bleeding.
Attitudes and Perceived Barriers to Research Among Residents in Obstetrics and Gynecology in Trinidad and Tobago: A National Multicenter Cross-sectional Study
Authors: Persad Sunil , Mehra Saksham , Harry Vanessa 
Published: April 2023

OBJECTIVES High-quality research forms the basis of evidence-based practice and sets the foundation for trainees to develop critical thinking skills and approach clinical problems with an inquisitive mind. The attitudes to research however vary widely and there are significant barriers to conducting research relevant to each clinical discipline. Understanding both the attitudes of residents to research and the barriers to conducting research could allow for strategies to improve this core aspect of clinical development. This aim of this study was to characterise current attitudes and perceived barriers towards conducting research among residents in Obstetrics and Gynecology in Trinidad and Tobago. METHODS An online survey was sent to all residents in the four major public hospitals in Trinidad and Tobago. The 10-min previously piloted questionnaire contained questions related to demographics, career level, research experience, attitudes to research as well as perceived barriers to conducting research. RESULTS The response rate was 74% (48/65). Although most (77%) respondents were interested in performing research, lack of time (56%) and insufficient training in research (59%) were the main barriers. Lack of mentorship or supervision as well as departmental issues such as access to case notes, electronic databases and bureaucratic issues were also found to hamper a research-oriented environment. CONCLUSION For residents in Obstetrics and Gynecology, curricula revision is urgently required to include protected research time, training in research methodology, formal and dedicated research mentors in order to promote a research-oriented culture that ensures a greater understanding and output of research in this specialty.
clusterMaker2: a major update to clusterMaker, a multi-algorithm clustering app for Cytoscape
Authors: Utriainen Maija , Morris John H. 
Published: April 2023

AbstractBackgroundSince the initial publication ofclusterMaker, the need for tools to analyze large biological datasets has only increased. New datasets are significantly larger than a decade ago, and new experimental techniques such as single-cell transcriptomics continue to drive the need for clustering or classification techniques to focus on portions of datasets of interest. While many libraries and packages exist that implement various algorithms, there remains the need for clustering packages that are easy to use, integrated with visualization of the results, and integrated with other commonly used tools for biological data analysis.clusterMaker2has added several new algorithms, including two entirely new categories of analyses: node ranking and dimensionality reduction. Furthermore, many of the new algorithms have been implemented using the CytoscapejobsAPI, which provides a mechanism for executing remote jobs from within Cytoscape. Together, these advances facilitate meaningful analyses of modern biological datasets despite their ever-increasing size and complexity.ResultsThe use ofclusterMaker2is exemplified by reanalyzing the yeast heat shock expression experiment that was included in our original paper; however, here we explored this dataset in significantly more detail. Combining this dataset with the yeast protein–protein interaction network from STRING, we were able to perform a variety of analyses and visualizations from withinclusterMaker2, including Leiden clustering to break the entire network into smaller clusters, hierarchical clustering to look at the overall expression dataset, dimensionality reduction using UMAP to find correlations between our hierarchical visualization and the UMAP plot, fuzzy clustering, and cluster ranking. Using these techniques, we were able to explore the highest-ranking cluster and determine that it represents a strong contender for proteins working together in response to heat shock. We found a series of clusters that, when re-explored as fuzzy clusters, provide a better presentation of mitochondrial processes.ConclusionsclusterMaker2represents a significant advance over the previously published version, and most importantly, provides an easy-to-use tool to perform clustering and to visualize clusters within the Cytoscape network context. The new algorithms should be welcome to the large population of Cytoscape users, particularly the new dimensionality reduction and fuzzy clustering techniques.
Insight into the evolutionary and domesticated history of the most widely cultivated mushroom Agaricus bisporus via mitogenome sequences of 361 global strains
Authors: Zhang Ming-Zhe , Xu Jian-Ping , Callac Philippe , Chen Mei-Yuan , Wu Qi , Wach Mark , Mata Gerardo , Zhao Rui-Lin 
Published: April 2023

AbstractAgaricus bisporus is the most widely cultivated edible mushroom in the world with a only around three hundred years known history of cultivation. Therefore, it represents an ideal organism not only to investigate the natural evolutionary history but also the understanding on the evolution going back to the early era of domestication. In this study, we generated the mitochondrial genome sequences of 352 A. bisporus strains and 9 strains from 4 closely related species around the world. The population mitogenomic study revealed all A. bisporus strains can be divided into seven clades, and all domesticated cultivars present only in two of those clades. The molecular dating analysis showed this species origin in Europe on 4.6 Ma and we proposed the main dispersal routes. The detailed mitogenome structure studies showed that the insertion of the plasmid-derived dpo gene caused a long fragment (MIR) inversion, and the distributions of the fragments of dpo gene were strictly in correspondence with these seven clades. Our studies also showed A. bisporus population contains 30 intron distribution patterns (IDPs), while all cultivars contain only two IDPs, which clearly exhibit intron loss compared to the others. Either the loss occurred before or after domestication, that could suggest that the change facilitates their adaptation to the cultivated environment.
Myocardial injury defined as elevated high-sensitivity cardiac troponin T is associated with higher mortality in patients seeking care at emergency departments with acute dyspnea
Authors: Wessman T , Zorlak A , Wändell Per , Melander O , Carlsson AC , Ruge T 
Published: April 2023

Abstract
Background
Elevated levels of cardiac troponin T has been observed in patients seeking care at the emergency department (ED) presenting with chest pain but without myocardial infarction (MI). The clinical importance of this observation remains, however, still unclear. Our main aim was to study the role of cardiac troponin T in patients admitted to the emergency department with acute dyspnea, a group of patients with a high cardiovascular comorbidity, but no primary acute MI.

Population and methods
Patients from the age of 18 seeking care at the ED for dyspnea, without an acute cardiac syndrome, and with a recorded assessment of high-sensitivity cardiac troponin T (hs-cTnT), were included (n = 1001). Patients were categorized into 3 groups by hs-cTnT level, i.e. <15, 15–100 and > 100 µg/l. Cox regression with Hazard Ratios (HRs) and 95% Confidence Intervals (CI) for 3-months mortality was performed, with adjustment for sex, age, respiratory frequency, saturation, CHF, renal disease, and BMI.

Results
Fully adjusted HRs (95% CI) for 3-month mortality, with hs-cTnT < 15 µg/l as reference level, showed for hs-cTnT 15–100 a HR of 3.682 (1.729–7.844), and for hs-cTnT > 100 a HR of 10.523 (4.465–24.803).

Conclusion
Elevated hs-cTnT seems to be a relevant marker of poor prognosis in patients with acute dyspnea without MI and warrants further validation and clinical testing.
Post-COVID-19 condition and persisting symptoms in English schoolchildren: repeated surveys to March 2022
Authors: Warren-Gash Charlotte , Lacey Andrea , Cook Sarah , Stocker Dylan , Toon Samantha , Lelii Ffion , Ford Ben , Ireland Georgina , Ladhani Shamez N. , Stephenson Terence , Nguipdop-Djomo Patrick , Mangtani Punam ,   the COVID-19 Schools Infection Survey 2 Study Group, McClenahan Elliot , McKay Gillian , Phelan Jody , Lin Liang-Yu , Lewin Alex , Judd Alison , Davies Byron , Saib Anisah , McCrae James , Kelly Joe , Diamond Ian , Rourke Emma , Dawe Fiona , Jones Pete 
Published: April 2023

Abstract
Background
Both post-COVID-19 condition (long COVID) and the presence of persisting symptoms that do not meet formal definitions of post-COVID-19-condition may adversely affect quality of life and function. However, their prevalence among children and young people in England is unclear.

Methods
We used data from repeated surveys in a large cohort of English schoolchildren from the COVID-19 Schools Infection Survey (SIS) for the school year 2021/22 to describe the weighted prevalence of post-COVID-19-condition and compare persisting symptoms between individuals with a positive SARS-CoV-2 test and those with neither a positive test history nor suspected infection.

Results
Among 7797 children from 173 schools, 1.8% of primary school pupils (aged 4 to 11 years), 4.5% of secondary school pupils in years 7–11 (aged 11 to 16 years) and 6.9% of those in years 12–13 (aged 16 to 18 years) met a definition of post-COVID-19 condition in March 2022. Specific persisting symptoms such as anxiety or difficulty concentrating were frequently reported regardless of prior infection status and increased with age: 48.0% of primary school pupils, 52.9% of secondary school pupils in years 7–11 and 79.5% in years 12–13 reporting at least one symptom lasting more than 12 weeks. Persisting loss of smell and taste, cardiovascular and some systemic symptoms were more frequently reported by those with a previous positive test.

Conclusions
We showed that ongoing symptoms were frequently reported by English schoolchildren regardless of SARS-CoV-2 test results and some specific symptoms such as loss of smell and taste were more prevalent in those with a positive test history. Our study emphasises the wide-ranging impacts of the COVID-19 pandemic on the health and wellbeing of children and young people.