bluuebunny/crossref_metadata_2025_split huggingface dataset:
Range‐edge populations of seaweeds show niche unfilling and poor adaptation to increased temperatures
Authors: Hernández Sandra , García Ana G. , Arenas Francisco , Escribano M. Pilar , Jueterbock Alexander , De Clerck Olivier , Maggs Christine A. , Franco João N. , Martínez Brezo D. C. 
Published: February 2023

AbstractAimGlobal warming is affecting the distribution of species worldwide, but the level of adaptation of edge populations to warmer temperatures remains an open question. Here, we assess the thermal tolerance of populations of two habitat‐forming seaweeds along their latitudinal range, using thermal niche unfilling to assess their resilience to global warming.LocationEuropean Atlantic coastline.TaxonAscophyllum nodosum (Linnaeus) Le Jolis (Phaeophyceae) and Chondrus crispus Stackhouse (Rhodophyta).MethodsWe studied the ecotypic variation in upper survival temperatures (USTs) by measuring survival and growth of adults representing populations under a gradient of seawater temperature (12–30°C). Comparing the USTs with maximum seawater temperatures obtained from satellites, we investigated safety margins and niche unfilling states, both in recent history and under future climate scenarios.ResultsUSTs (≈24°C) did not differ significantly between populations, except for higher values (27.9°C) for the northernmost populations (cold edge) of A. nodosum. Populations of both species had thermal safety margins over the last few decades (from 1982 to 2021). However, projections based on USTs showed that in several years these margins have been eliminated and will completely disappear in the Bay of Biscay under RCP4.5 and RCP6.0 2090–2100 IPCC scenarios for C. crispus and under RCP8.5 for both species, threatening the populations there.Main ConclusionsSouthern marginal populations were not better adapted to global warming than populations elsewhere. Both seaweed species tolerated higher temperatures than the ambient maxima, suggesting a thermal niche unfilling state with thermal safety margins in their recent history. However, those are being depleted by ongoing climate change and this trend is predicted to increase. Marine heat waves are important threats to these habitat‐forming species, transiently reducing or even eliminating safety margins in the hottest parts of the European Atlantic coastline, contributing to explaining the distributional gap there.
Impact of unipolar voltage criteria for left atrial posterior wall on atrial fibrillation recurrence after pulmonary vein isolation
Authors: Watanabe Tomonori , Watanabe Hiroaki , Hachiya Hitoshi , Sato Masafumi , Mitama Tadayuki , Okuyama Takafumi , Yokota Ayako , Kamioka Masashi , Komori Takahiro , Kabutoya Tomoyuki , Imai Yasushi , Kario Kazuomi 
Published: February 2023

AbstractIntroductionBeyond pulmonary vein isolation (PVI), additional therapeutic strategies for atrial fibrillation (AF) have not been established. Remodeling of the left atrium (LA) could impact AF recurrence post‐PVI. We investigated the impact of unipolar voltage (UV) criteria for the LA posterior wall (LA‐PW) on AF recurrence post‐PVI.MethodsWe reviewed the cases of 106 AF patients (mean age 63.8 years, nonparoxysmal AF: 59%) who underwent extensive encircling PVI by radiofrequency ablation guided by a 3‐dimension mapping system, investigating the impact on AF recurrence of the UV criteria of the LA.ResultsOut of all patients, 26 patients had AF recurrence during post‐PVI follow‐up [median 603 days]. They showed a higher percentage of nonparoxysmal AF (80.8 vs. 52.5%, p = .011), longer AF duration (2.9 ± 2.7 vs. 1.0 ± 1.7 years, p = .002), and larger area size of UV < 2.0 mV in LA‐PW (2.8 ± 1.8 vs. 1.0 ± 1.5 cm2, p < .001) than those without recurrence. Cox Hazard analysis for AF recurrence adjusted by age, gender, AF duration, body mass index and left atrial volume index revealed that an area size over 2.0 cm2 of UV < 2.0 mV in LA‐PW (HR 6.9 [95% CI:1.3–35.5], p = .021) posed independent risks for AF recurrence post‐PVI. The atrial arrhythmia‐free survival rate was higher in those with no area of UV < 3.0 mV in LA‐PW compared to those with a sizable area (>2.0 cm2) of UV < 3.0 mV and <2.0 mV (95.0% vs. 74.2% vs. 57.1%, Log‐Rank: p < .001). In the AF etiology of patients with AF recurrence, 9 of 14 patients who underwent the 2nd procedure had no PV reconnection, and 8 patients required the LA‐PW isolation for their non‐PV AF.ConclusionUV criteria of LA‐PW is a useful parameter for AF‐recurrence post‐PVI. Lower UV in LA‐PW as an indication of electrical remodeling could indicate a higher risk of AF recurrence and the need for further therapeutic strategies.
Relationship between amiodarone response prior to ablation and 1‐year outcomes of catheter ablation for atrial fibrillation
Authors: Yadav Ritu , Brilliant Justin , Akhtar Tauseef , Milstein Jenna , Sampognaro James R. , Marine Joseph , Berger Ronald , Calkins Hugh , Spragg David 
Published: February 2023

AbstractIntroductionCatheter ablation for atrial fibrillation (AF) is a common therapeutic strategy for patients with either paroxysmal AF (PAF) or persistent AF (persAF), but long‐term ablation success rates are imperfect. Maintenance of sinus rhythm immediately before ablation with antiarrhythmic drug (AAD) therapy has been associated with improved outcomes in patients undergoing ablation. Amiodarone has superior efficacy relative to other AADs. Whether failure of amiodarone to maintain sinus rhythm before ablation for either PAF or persAF is associated with poor outcomes is unknown.MethodsA total of 307 patients who received amiodarone in a 1‐year window before undergoing catheter ablation for AF were included. Patients were divided into amiodarone success (n = 183) and amiodarone failure (n = 124) groups based on the response to pre‐ablation amiodarone treatment. Analysis of procedural outcomes as a function of response to amiodarone therapy was performed. Patients were followed for at least 12 months postablation, to assess outcomes (adverse events and arrhythmia recurrence). Procedural success was defined by the absence of documented arrhythmia (>30 s) without any antiarrhythmic agents beyond a 90‐day blanking period.ResultsFollowing ablation for either PAF or persAF, freedom from any recurrent atrial arrhythmia at 1 year was 57.7% for the entire cohort. One‐year freedom from recurrent arrhythmia in the amiodarone success group was comparable to that in the amiodarone failure group (55.7% vs. 60.5%; p = .54). Success rates following ablation did not vary by the response to amiodarone when analyzed for PAF or persAF subgroups.ConclusionFailure to restore and maintain sinus rhythm with amiodarone before ablation for either PAF or persAF is not a predictor of ablation procedural failure. Amiodarone failure alone should not deter practitioners from considering ablation therapy for patients with AF.
Effect of scar and His–Purkinje and myocardium conduction on response to conduction system pacing
Authors: Strocchi Marina , Gillette Karli , Neic Aurel , Elliott Mark K. , Wijesuriya Nadeev , Mehta Vishal , Vigmond Edward J. , Plank Gernot , Rinaldi Christopher A. , Niederer Steven A. 
Published: February 2023

AbstractIntroductionConduction system pacing (CSP), in the form of His bundle pacing (HBP) or left bundle branch pacing (LBBP), is emerging as a valuable cardiac resynchronization therapy (CRT) delivery method. However, patient selection and therapy personalization for CSP delivery remain poorly characterized. We aim to compare pacing‐induced electrical synchrony during CRT, HBP, LBBP, HBP with left ventricular (LV) epicardial lead (His‐optimized CRT [HOT‐CRT]), and LBBP with LV epicardial lead (LBBP‐optimized CRT [LOT‐CRT]) in patients with different conduction disease presentations using computational modeling.MethodsWe simulated ventricular activation on 24 four‐chamber heart geometries, including His–Purkinje systems with proximal left bundle branch block (LBBB). We simulated septal scar, LV lateral wall scar, and mild and severe myocardium and LV His–Purkinje system conduction disease by decreasing the conduction velocity (CV) down to 70% and 35% of the healthy CV. Electrical synchrony was measured by the shortest interval to activate 90% of the ventricles (90% of biventricular activation time [BIVAT‐90]).ResultsSevere LV His–Purkinje conduction disease favored CRT (BIVAT‐90: HBP 101.5 ± 7.8 ms vs. CRT 93.0 ± 8.9 ms, p < .05), with additional electrical synchrony induced by HOT‐CRT (87.6 ± 6.7 ms, p < .05) and LOT‐CRT (73.9 ± 7.6 ms, p < .05). Patients with slow myocardium CV benefit more from CSP compared to CRT (BIVAT‐90: CRT 134.5 ± 24.1 ms; HBP 97.1 ± 9.9 ms, p < .01; LBBP: 101.5 ± 10.7 ms, p < .01). Septal but not lateral wall scar made CSP ineffective, while CRT was able to resynchronize the ventricles in the presence of septal scar (BIVAT‐90: baseline 119.1 ± 10.8 ms vs. CRT 85.1 ± 14.9 ms, p < .01).ConclusionSevere LV His–Purkinje conduction disease attenuates the benefits of CSP, with additional improvements achieved with HOT‐CRT and LOT‐CRT. Septal but not lateral wall scars make CSP ineffective.
The MAX2‐KAI2 module promotes salicylic acid‐mediated immune responses in Arabidopsis
Authors: Zheng Xiujuan , Liu Fangqian , Yang Xianfeng , Li Weiqiang , Chen Sique , Yue Xinwu , Jia Qi , Sun Xinli 
Published: February 2023

ABSTRACTArabidopsis MORE AXILLARY GROWTH2 (MAX2) is a key component in the strigolactone (SL) and karrikin (KAR) signaling pathways and regulates the degradation of SUPPRESSOR OF MAX2 1/SMAX1‐like (SMAX1/SMXL) proteins, which are transcriptional co‐repressors that regulate plant architecture, as well as abiotic and biotic stress responses. The max2 mutation reduces resistance against Pseudomonas syringae pv. tomato (Pst). To uncover the mechanism of MAX2‐mediated resistance, we evaluated the resistance of various SL and KAR signaling pathway mutants. The resistance of SL‐deficient mutants and of dwarf 14 (d14) was similar to that of the wild‐type, whereas the resistance of the karrikin insensitive 2 (kai2) mutant was compromised, demonstrating that the KAR signaling pathway, not the SL signaling pathway, positively regulates the immune response. We measured the resistance of smax1 and smxl mutants, as well as the double, triple, and quadruple mutants with max2, which revealed that both the smax1 mutant and smxl6/7/8 triple mutant rescue the low resistance phenotype of max2 and that SMAX1 accumulation diminishes resistance. The susceptibility of smax1D, containing a degradation‐insensitive form of SMAX1, further confirmed the SMAX1 function in the resistance. The relationship between the accumulation of SMAX1/SMXLs and disease resistance suggested that the inhibitory activity of SMAX1 to resistance requires SMXL6/7/8. Moreover, the exogenous application of KAR2 enhanced resistance against Pst, but KAR‐induced resistance depended on salicylic acid (SA) signaling. Inhibition of karrikin signaling delayed SA‐mediated defense responses and inhibited pathogen‐induced protein biosynthesis. Together, we propose that the MAX2–KAI2–SMAX1 complex regulates resistance with the assistance of SMXL6/7/8 and SA signaling and that SMAX1/SMXLs possibly form a multimeric complex with their target transcription factors to fine tune immune responses.
Chronic inflammatory demyelinating polyradiculoneuropathy: Diagnostic problems in clinical practice in Serbia
Authors: Basta Ivana , Delic Neda , Gunjic Ilija , Arsenijevic Zdraljevic Mirjana , Kacar Aleksandra , Bozovic Ivo , Peric Stojan 
Published: February 2023

AbstractMaking diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is challenging since it can mimic a multitude of disorders, and is misdiagnosed in at least 50% of cases. We sought to determine the frequency of CIDP misdiagnosis in clinical practice in Serbia, to uncover CIDP mimics, and to identify factors that may aid in CIDP diagnosis. Our longitudinal retrospective cohort study included 86 eligible adult patients referred to the Neurology Clinic, University Clinical Centre of Serbia, with a diagnosis of CIDP. We also included 15 patients referred to us with different diagnoses that ended up having CIDP as their final diagnosis. Exactly half of patients referred as CIDP failed to meet the established diagnostic criteria (non‐CIDP) and were given an alternative diagnosis at the first hospitalization. At the 1‐year follow‐up, the diagnosis was further revised in four subjects. Confirmed CIDP patients usually had their initial diagnosis based on the nerve conduction studies (NCS), a typical presentation with symmetrical involvement of all four limbs, as well as higher frequencies of elevated protein levels and albuminocytologic dissociation in the cerebrospinal fluid (CSF). CIDP patients also responded better to immune therapy. We found that 52% of the patients initially referred to our Clinic as CIDP were given other diagnoses after a 1‐year follow‐up. Out of all CIDP cases, 27% had been unrecognized prior to referral to our Center. Utilization of clear and objective indicators ‐ conclusive NCS, improvement on therapy, and elevated CSF proteins may provide greater certainty in diagnosing CIDP.
Model Secrecy and Stress Tests
Authors: LEITNER YARON , WILLIAMS BASIL 
Published: February 2023

ABSTRACTShould regulators reveal the models they use to stress‐test banks? In our setting, revealing leads to gaming, but secrecy can induce banks to underinvest in socially desirable assets for fear of failing the test. We show that although the regulator can solve this underinvestment problem by making the test easier, some disclosure may still be optimal (e.g., if banks have high appetite for risk or if capital shortfalls are not very costly). Cutoff rules are optimal within monotone disclosure rules, but more generally optimal disclosure is single‐peaked. We discuss policy implications and offer applications beyond stress tests.
Modeling the risk factors of women with very severe menopausal symptoms
Authors: Koçak Derya Yüksel , Beji Nezihe Kizilkaya 
Published: February 2023

AbstractAimIndividual differences and sociodemographic, gynecological, and cultural characteristics affect the severity of menopausal symptoms. This study aimed to reveal the severity of menopausal symptoms experienced by Turkish women and the risk factors that cause women to experience very severe menopausal symptoms.MethodsThis cross‐sectional and descriptive study was conducted with 435 women in menopause. The Personal Information Form and the Menopause Rating Scale were used to collect data. In logistic regression analysis, backward stepwise Wald binary logistic regression method was used. In the logistic regression analysis, there were 30 independent variables. The dependent variable was determined as the total MRS score.ResultsThe mean score of the somatic symptoms sub‐dimension was 3.14 ± 2.12, the mean score of the psychological symptoms sub‐dimension was 10.11 ± 5.66, and the mean score of the urogenital symptoms sub‐dimension was 3.58 ± 2.90. The total mean score of the Menopause Rating Scale was 16.83 ± 9.31. Menopausal age between 44 and 50 years old (OR = 10.681), having a chronic illness (OR = 6.432), having more than 5 pregnancies (OR = 5.372), and spouse's primary school or below education level (OR = 4.02) increase the severity of menopausal symptoms.ConclusionIt is recommended that healthcare professionals evaluate the symptoms of women in the menopause period to provide them with psychological and social support and to help the spouse and family cooperate with women in menopause in compliance with the process.
Comparing the prognosis of in vitro fertilization/intracytoplasmic sperm injection and embryo transfer between unexplained primary infertility patients with repeated artificial insemination with homologous semen failure and tubal infertility patients
Authors: Ma Wenhong , Zeng Zhonghong , Xie Jiayan , Wang Xi , Li Liuming , Yang Yihua 
Published: February 2023

AbstractBackgroundBoth in vitro fertilization and embryo transfer (IVF‐ET) and intracytoplasmic sperm injection and embryo transfer (ICSI‐ET) have been recommended for unexplained primary infertility after recurrent artificial insemination with homologous semen failure (UAIHF), but few studies focused on the safety and efficiency of the IVF/ICSI‐ET technique for these patients. In this study, we compared the IVF/ICSI‐ET outcomes and perinatal and postnatal complications between UAIHF patients and tubal infertility (TI) patients.MethodsWe conducted a retrospective study of UAIHF and TI patients who underwent IVF/ICSI‐ET at Guangxi Reproductive Medical Center, the First Affiliated Hospital of Guangxi Medical University from January 2012 to March 2021. After propensity score matching (PSM), we analyzed the IVF/ICSI‐ET outcomes and rates of perinatal and postnatal complications.ResultsPSM analysis revealed that the baselines of age, infertility duration, and body mass index were comparable. The fertilization method was significantly different between the two groups. Through IVF/ICSI‐ET, UAIHF patients had a similar clinical outcome compared to TI patients. Regarding perinatal and postnatal complications, the incidence of premature rupture of membranes (PROM) (7.54% vs. 3.17%,p = 0.030) was significantly higher in UAIHF patients.ConclusionsUAIHF patients could achieve satisfying pregnancy outcomes by IVF/ICSI‐ET. ICSI‐ET did not seem to improve the clinical outcomes of UAIHF patients compared to those of TI patients who underwent IVF‐ET, which might be related to possible underlying diseases in these patients. In addition, the incidence of PROM was significantly higher in UAIHF patients, which might be related to the ICSI technique used and uncertain potential idiopathic diseases associated with unexplained infertility patients. Trial registration: Chinese Clinical Trial Registry, ChiCTR2200057572. Registered 15 March 2022.
Predicting Big Five personality traits from smartphone data: A meta‐analysis on the potential of digital phenotyping
Authors: Marengo Davide , Elhai Jon D. , Montag Christian 
Published: February 2023

AbstractObjectiveSince the first study linking recorded smartphone variables to self‐reported personality in 2011, many additional studies have been published investigating this association. In the present meta‐analyses, we aimed to understand how strongly personality can be predicted via smartphone data.MethodMeta‐analytical calculations were used to assess the association between smartphone data and Big Five traits. Because of the lack of independence of many included studies, analyses were performed using a multilevel approach.ResultsBased on data collected from 21 distinct studies, extraversion showed the largest association with the digital footprints derived from smartphone data (r = .35), while remaining traits showed smaller associations (ranging from 0.23 to 0.25). For all traits except neuroticism, moderator analyses showed that prediction performance was improved when multiple features were combined together in a single predictive model. Additionally, the strength of the prediction of extraversion was improved when call and text log data were used to perform the prediction, as opposed to other types of smartphone dataConclusionsOur synthesis reveals small‐to‐moderate associations between smartphone activity data and Big Five traits. The opportunities, but also dangers of the digital phenotyping of personality traits based on traces of users' activity on a smartphone data are discussed.
Effect of feed enzymes and functional immunostimulants supplementation on growth performance and overall health of postlarvae and juvenile Pacific white shrimp, Penaeus vannamei, fed soybean‐based diets
Authors: Chuchird Niti , Rairat Tirawat , Keetanon Arunothai , Seguin Daranee , Chotikachinda Rutchanee , Manomaitis Lukas , Kanjanamayoon Chuchai 
Published: February 2023

AbstractSoybean meal (SBM) is widely used in shrimp feed agro‐industry as a fish meal (FM) replacement. However, high levels of SBM may compromise animal health as a result of nutrient imbalance. This study aimed to investigate the effects of feed enzyme combination (a mixture of 6‐phytase, serine protease, and endo‐1,3(4)‐β‐glucanase) and functional immunostimulant combination (a mixture of brewer's yeast, nucleotides, vitamin C, and vitamin E) in improving the overall health of Pacific white shrimp fed soybean‐based diet. Four diets were formulated with different amounts of SBM, FM, and poultry meal (PM): 0% SBM (with 25% FM and 12.6% PM), 30% SBM (with 12.5% FM and 5.7% PM), 30% SBM plus 0.045% feed enzymes, and 30% SBM plus 0.1% functional immunostimulants. The postlarvae were fed the test diets for 45 days. Then, the body weight, survival, FCR, Vibrio spp. count, and immune responses were analyzed. The resistance of shrimp to Vibrio parahaemolyticus infection was also evaluated. The results suggest that the diet with 30% SBM was deleterious to the shrimp's health. Feed enzymes and functional immunostimulant supplements improved overall performance, immune function, and resistance to V. parahaemolyticus infection of shrimp fed the diet containing 30% SBM compared with the 30% SBM diet without feed supplements.
Foreign passive ownership and tariff‐induced free technology transfer under vertical integration
Authors: Zhang Chuyuan , Lee Sang‐Ho 
Published: February 2023

AbstractThis study constructs a vertical structure model in which a foreign firm holds upstream partial passive ownership and examines tariff‐induced free technology transfer from the firm to its downstream rival. We show that a strategic tariff can induce technology transfer when the share of foreign ownership is large, which always yields higher welfare under both vertical separation and integration, while vertical integration can better induce technology transfer. We also consider an extensive analysis with some variations, such as upstream or downstream competition, downstream passive ownership, government commitments to no‐tariff policies, and foreign firm commitments to no‐licensing strategies, and discuss policy implications regarding the pro‐competitive effect of foreign passive ownership when free technology transfer is involved.
Why have a bottle when you can have draught? Exploring bottle refusal by breastfed babies
Authors: Maxwell Clare , Fleming Valerie , Porcellato Lorna 
Published: February 2023

AbstractBottle refusal by breastfed babies is a scenario that has received surprisingly little attention in the literature, given the number of mothers who appear to be experiencing it globally and the subsequent negative impact it can have. In line with this, we undertook a study to explore mothers’ views on why their breastfed baby refuses to bottle feed. A parallel, two‐stage, exploratory qualitative design was employed using 30 semi‐structured interviews and 597 online forum posts. Data were analysed using a thematic analysis, and a biopsychosocial model was applied resulting in four overarching themes being identified: ‘Breastfeeding is the answer to everything….’ ‘Bottle feeding: an alien concept… ‘Babies are individuals’ and ‘Find the right bottle and don't delay’. The psychological benefits of breastfeeding, not inherent in bottle feeding, appeared to underpin some mothers’ views on their baby's refusal. Other mothers explained refusal as being down to a baby's biological expectation to be fed by the breast; therefore, bottle feeding was not a normal concept to them. A baby's individual personality and temperament were also suggested as contributing to the scenario and refusal was linked to babies disliking a certain brand of bottle and being introduced to it ‘too late’. This study's findings point to a complex, multifactorial picture underpinning bottle refusal by breastfed babies, which transcends physical, psychological and biological concepts, and is influenced by socio‐cultural norms surrounding infant feeding. Recognition of these contributing factors is needed to aid those supporting mothers experiencing the scenario and, importantly, to underpin mothers’ decision‐making around managing it.