bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artemisinin-naphthoquine plus lower-dose primaquine to treat and prevent recurrence of Plasmodium vivax malaria: an open-label randomized and non-inferiority trial
Authors: Liu Hui , Xu Jian-Wei , Deng Dao-Wei , Yaw Bi , Nbwi Hkawn Shawng , Wei Chun , Zhou Xing-Wu , Li Jian-Xiong 
Published: July 2023

Abstract
Background: Plasmodium vivax malaria with the widest geographic distribution is also capable of causing severe disease and death. Primaquine is the main licensed antimalarial drug that can kill hypnozoites. The dose-dependent acute haemolysis in individuals with glucose-6-phospate dehydrogenase (G6PD) deficiency is the main safety concern in use of primaquine. The recommended treatment regimen for P. vivax malaria is chloroquine plus primaquine over 14 days (CQPQ14) in Myanmar. The study aimed to evaluate the therapeutic efficacy, safety and adherence of the regimen of artemisinin-naphthoquine plus primaquine over 3 days (ANPQ3) in patients of P. vivax infections compared to those of CQPQ14.
Methods: A patient in group ANPQ3 was given fixed-dose artemisinin-naphthoquine (a total 24.5mg per kilogram) plus a lower total primaquine dose (0.9 mg per kilogram)over 3 days (group ANPQ3). The patient in group CQPQ14 were given a total chloroquine dose of 30 mg per kilogram of body weight over 3 days plus a total primaquine dose of 4.2 mg per kilogram over 14 days. All patients were followed up for 365 days.
Results: A total of 288 patients were completed follow up, 172 in group ANPQ3 and 116 in group CQPQ14. No recurrences were observed till day 57. By day 182, a total 31 recurrences were recorded: 12 (7.0%) in Group ANPQ3 and 4 (3.4%) patients in Group CQPQ14. The difference of recurrence-free patients was 3.5 (-8.6 – 1.5) percentage points between group ANPQ3 and group CQPQ14 (P=0.2946). By day 365, the percentage of recurrence-free patient was not significant between the two groups (P=0.2257). Mean fever and parasite clearance time of group ANPQ3 were shorter than those of group CQPQ14 (P≤0.001). No any severe adverse effect was observed in group ANPQ3, but 5 (3.9%) patients with acute haemolysis in group CQPQ14 (P=0.013).Medication percentage of group ANPQ3 was significantly higher than that of group CQPQ14 (P<0.0001).
Conclusions: The radial cue efficacy is no non-inferiority between the ANPQ3 and the CQPQ14. The ANPQ3 clears fever and parasites faster than the CQPQ14. The ANPQ3 is a safer and better adherence treatment regimen for P. vivax malaria along China-Myanmar border.
Prospects for New Antibiotics Discovered through Genome Analysis
Authors: Singh Arun Kumar , Malviya Rishabha , Sharma Rishav 
Published: July 2023

Abstract:
Antibiotic-resistant illnesses are on the rise worldwide, and the pipeline for developing new antibiotics is drying up. As a result, researchers need to create novel compounds with antimicrobial action. Recent decades have seen a dearth of novel antibiotics because of the reliance on conventional empirical screening procedures using both natural and synthetic chemicals to find them. There is hope that the massive amount of bacterial genome sequence data that has become accessible since the sequencing of the first bacterial genome more than 20 years ago might help lead to the development of new antibiotic drugs. Genes with significant levels of conservation both within and between bacterial species can be found using comparative genomic techniques; these genes may be involved in essential bacterial functions. Bioactive chemicals found in natural products have been successfully used in treating everything from infectious diseases to cancer, but over the past 20-30 years, the effectiveness of screening methods based on fermentation has decreased. Researchers urgently need answers to the unmet demand for bacterial infection resistance. Now more than ever, with the advent of cheap, high-throughput genomic sequencing technology, natural product discovery can be revitalized. Using bioinformatics, investigators may foretell whether or not a certain microbial strain would generate compounds with novel chemical structures, which may have novel modes of action in inhibiting bacterial growth. This manuscript describes how this potential might be utilised, with a particular emphasis on manipulating the expression of dormant biosynthetic gene clusters that are hypothesised to encode new antibiotics. Additionally, it consolidates the work of the past and the present to utilise bacterial genomic data in the identification and development of new antibiotics.
Maxims of Politeness Performed by Female Sellers at Traditional Market in Sumatera Barat
Authors: Revita Ike , Marwati Sofia , Ayumi Ayumi , Mardiah Ainun 
Published: July 2023

This research is aimed at describing the maxims of politeness used by female sellers in a traditional market in Sumatera Barat. The research was conducted in one tradititonal market in Sumatera Barat, namely Batu Sangkar. The data are any utterances produced by female sellers in a traditional market in a traditional market in Batu Sangkar. The data were taken by the observational method with note-taking, recording, and interviewing techniques. The analysis was done by using the concept proposed by (Oktavianus & Revita, 2013; Leech, 1983). The result of the analysis was descriptively done and used the chart. The percentage was also used to identify the number of maxims that occurred. Having analyzed the data, it is found that the female sellers used four maxims in their interaction with the buyers. They are 1) tact, 2) agreement, and 3)modesty. There are two types of agreement between the sellers and the buyers, namely using 1) verbal and 2) non-verbal agreement. The non-verbal agreement is the indication of the insincerity of the sellers of the price bargained by the buyers. The sellers do not get much profit from the price offered by the buyers.
Development of cognitive activity of older preschool children with disabilities of the compensating group
Authors: Куфтерина А.С. , Мамедова Л.В. 
Published: July 2023

В статье было отражено проведенное исследование, направленное на изучение развития познавательной активности детей старшего дошкольного возраста. Подобранные методы и приемы, направленные на развитие познавательной активности детей старшего дошкольного возраста с ОВЗ, могут быть полезны психологам, педагогам специальных образовательных учреждений и студентами педагогических специальностей при прохождении производственной практики. Были сделаны выводы, что динамика уровня развития познавательной активности у детей старшего дошкольного возраста после проведенных занятий стала положительной, таким образом, проведенная нами работа была эффективной. Данное исследование посвящено развитию познавательной активности детей старшего дошкольного возраста с ограниченными возможностями здоровья (ОВЗ) в компенсирующей группе. Авторы исследуют методы и подходы, направленные на стимулирование познавательных процессов у детей с ОВЗ. Работа основана на анализе педагогического опыта и эмпирических данных. В статье рассматриваются факторы, влияющие на развитие познавательной активности детей с ОВЗ, и приводятся примеры эффективных практик и инновационных подходов в работе с такими детьми. Результаты исследования имеют важное значение для специалистов, занимающихся образованием и развитием детей с ОВЗ, и могут быть использованы в практике компенсирующих групп и специальных дошкольных учреждений.
The article reflects the conducted research aimed at studying the development of cognitive activity of older preschool children. The selected methods and techniques aimed at the development of cognitive activity of older preschool children with disabilities can be useful to psychologists, teachers of special educational institutions and students of pedagogical specialties during practical training. It was concluded that the dynamics of the level of cognitive activity development in older preschool children after the classes became positive, so the work we carried out was effective. This study is devoted to the development of cognitive activity of older preschool children with disabilities in the compensating group. The authors investigate methods and approaches aimed at stimulating cognitive processes in children with disabilities. The work is based on the analysis of pedagogical experience and empirical data. The article examines the factors influencing the development of cognitive activity of children with disabilities, and provides examples of effective practices and innovative approaches in working with such children. The results of the study are important for specialists involved in the education and development of children with disabilities, and can be used in the practice of compensating groups and special preschool institutions.
UTILIZATION OF FLY ASH FROM PLTU KETAPANG AS FILLER ON HOT ROLLED SHEET (HRS-Base)
Authors: Juanda Rizky Hendarta , Azwansyah Heri , Kadarini S. Nurlaily , Erwan Komala 
Published: July 2023

The utilization of stone dust waste produced from PLTU Ketapang coal combustion process is still below optimal level. Produced waste reached ± 23,13 ton /day which consists of 99,5% of fly ash and 0,5% bottom ash. As a result, the writer gained an idea of using fly ash as a filler in bitumen mixture, especially in Hot Rolled Sheet – BASE (HRS – BASE). The study was aimed to compare fly ash and stone dust if used as filler in Hot Rolled Sheet – BASE (HRS – BASE) mix in marshall test including void analysis which consistsed of VMA, VIM, VFB, and MQ. The planned test item concentration of tar was on the level of 6%, 6,5%, 7%, 7,5%, and 8%. The mixture which used stone dust as filler resulted in optimum bitumen content of 6,90% and the result of marshall test diplayed 912,072 kg of stability, 3,333 mm flow, 4,306% VIM, 18,018 % VMA, 82,681% VFB, and 273,745 kg/mm MQ. In the mixture which used fly ash as the filler resulted in optimum bitumen content of 7,1% with the marshall test displayed 877,132 kg of stability, 3,433 flow, 3,985% of VIM, 18,150% VFB, and the Marshall Quotient (MQ) 255,716 kg/mm.
The Role of Social Capital in Well-Being: A Bibliometric Perspective of the Literature
Authors: Herrera Maritza Alvarez , González Idolina Bernal , Verástegui Jesús Lavín 
Published: July 2023

Purpose of the Study: The objective of the study is to examine the literature trends that link the study of social capital with well-being.

Theoretical framework: The establishment of relationships within social capital, are characterized by mutual benefit, as well as trust and reciprocity between the actors within a certain community, for which the study of the subject of social capital related to well-being has gained relevance as a topic emerging in recent years.

Design/methodology/approach: The methodology used is through bibliometric tools on data extracted from the Web of Sciences platform, a total of 1248 indexed publications were reached, which provide a general and schematic overview of trends in research on the subject.

Findings: The results of annual scientific production, shows a growing trend in the development of publications related to the search terms raised in the research. Therefore, social capital represents an important element for the well-being of society, both individually and collectively, linked to elements such as trust, which is why they are strongly related to happiness, satisfaction with life and, consequently, with the well-being of the communities where social capital is present.

Research, Practical & Social implications: The study considers the relevance of the topic in the last five years, it can be clearly observed that more research on the subject is needed, so this can be a good start to this knowledge gap to increase interest and publications related to the subject.

Originality/value: The value of the study is the contribution it makes to the literature on the role of social capital in well-being. Therefore, the research can be of benefit to the scientific community with an interest in the study of the subject, since it will allow them to more efficiently identify the trends and areas of study on the subject.
Pengaruh Model Pembelajaran Kuantum Berbantuan Simulasi PHET Terhadap Penguasaan Konsep Fisika Peserta Didik
Authors: Aminah Siti , Doyan Aris , Hikmawati Hikmawati 
Published: July 2023

This research aim to into examine the effect of quantum learning model assisted phet simulation for students physic concept mastery. This type of research is quasi experiment with untreated control group design with pretest and posttest. The research popuplation was all students os XI MIA MAN 2 Mataram. Sampling technique of this research use cluster random sampling so that there are two classes that is XI MIA 5 as the experimental class and XI MIA 6 as the control class. Type test used 20 choice question for concept mastery. The posttest mean value for concept mastery in experimental class and control class is 54,29 and 44,54. Hypothesis testing of this research is MANOVA. The resul of MANOVA test show a significant 0,043 so H0 is rejected and Ha is accepted. The conclution of this research is there is the effect of quantum learning model assisted phet simulation for students physic concept mastery.
Analisis Miskonsepsi Siswa Pada Topik Pelajaran Tentang Gaya Gesek
Authors: Respasari Barinta Nur , Santika Heppy Dwi , Hasana Yosi , Hikmawati Hikmawati , Rokhmat Joni 
Published: July 2023

Penelitian ini bertujuan untuk dijadikan landasan dalam menyusun rencana pembelajaran agar guru mata pelajaran fisika dapat meminimalisir dan dapat mengatasi terjadinya miskonsepsi siswa pada konsep gaya gesek. Metode yang digunakan dalam penelitian ini adalah metode literature review. Peneliti mengumpulkan sumber referensi yang relevan sebagai bahan untuk membuat pembahasan. Hasil penelitian menunjukkan bahwa penyebab terjadinya miskonsepsi diakibatkan oleh informasi yang keliru dari teman, guru, atau sumber rujukan belajar lain, dan tidak lengkapnya pemahaman siswa terhadap konsep gaya gesek yang mereka pelajari. Pemikiran asosiatif siswa pada konsep gerak suatu objek secara keseluruhan dengan konsep gerak relatif objek yang mengalami gesekan, intuisi dalam bentuk gagasan yang diberikan oleh siswa muncul secara spontan tanpa sebelumnya secara objektif dan rasional diteliti/dianalisis. Reasoning yang salah atau tidak lengkap ketika siswa menganalisis gerak yang terjadi pada benda. Solusi yang ditawarkan untuk mengatasi miskonsepsi bagi guru antara lain: mencari atau menemukan bentuk-bentuk miskonsepsi, mencari penyebab terjadinya miskonsepsi, dan memilih metode yang sesuai untuk mengatasi miskonsepsi tersebut.
Keywords: misconceptions; student; friction
Influence of obesity on the tone of bronchial smooth muscles in rats
Authors: Birulina Ju. G. , Ivanov V. V. , Buyko E. E. , Voronkova O. V. , Hasanova R. R. , Volkhina M. O. , Nosarev A. V. , Gusakova S. V. 
Published: July 2023

Background. Overweight and obesity are key factors for the occurrence of many morphofunctional disorders in organs and tissues, including bronchopulmonary system.The aim. To study the influence of metabolic disorders that occur against the background of obesity on the state of the airways tone in rats.Materials and methods. Obesity in male Wistar rats was induced using a high-fat and high-carbohydrate diet. In animals, body weight and fat mass were measured, and the heart-lung complex was extracted. In blood serum, the levels of glucose, insulin, leptin, triglycerides, and cholesterol were assessed. Bronchoalveolar lavage fluid was obtained by an open method, in which the concentration of protein, interleukin (IL) 6 and IL-10 was determined. The contractile activity of the isolated bronchial smooth muscle segments was studied using mechanographic method. The effect of acetylcholine (10–7–10–4 M), indomethacin (10–5 M), and forskolin (10–7–10–5 M) on the changes in the tone of airway smooth muscles was assessed.Results. High-fat and high-carbohydrate diet caused an increase in body weight, visceral obesity, hyperglycemia, insulin resistance, leptinemia, dyslipidemia in rats of the experimental group. In the bronchoalveolar lavage fluid of experimental animals, an increase in the content of protein and IL-6 was found, which positively correlated with the level of leptin and the fat mass. In obese rats, the contractile responses of bronchial smooth muscle segments increased in response to the effect of the cholinergic agent acetylcholine. The bronchoconstrictor effect of acetylcholine was reduced by the cyclooxygenase inhibitor indomethacin. In turn, the adenylate cyclase activator forskolin caused relaxation of the airway segments smooth muscles in rats of both groups, which was more pronounced in the experimental group.Conclusion. The obtained results indicate that the change in the reactivity of the respiratory tract can be the cause of bronchospastic conditions in obesity and of the inflammatory reaction in the respiratory system induced by obesity.
THE DEVELOPMENT OF LEARNING MATERIALS PjBL-STEM TO IMPROVE STUDENTS’ SCIENTIFIC LITERACY SKILLS
Authors: Maghfirah Siti , Syukri Muhammad , Halim A , Mohammad Arsad Nurazidawati 
Published: July 2023

This study aims to develop the learning materials based on the STEM approach through the PjBL model that is feasible used to improve students’ scientific literacy in physics learning. The study is a development study using the ADDIE model which consists of five stages of development, namely Analysis, Design, Development, Implementation, and Evaluation. The subjects of this study were the students of grade 11th at SMA Negeri 5 Banda Aceh in the academic year 2019/2020. This study in the implementation stage used an experimental research design (quasi-experimental design) in which the model used was non-equivalent control group design by utilizing research instruments such as the questionnaire, validation questionnaire, and scientific literacy skills question test. The post-test results of students’ scientific literacy skills were then tested by using a t-test to investigate the differences between the experiment and control class. Based on the results of the study, the learning materials developed was feasibly used to improve students’ scientific literacy skill. AbstrakPenelitian ini bertujuan untuk mengembangkan perangkat pembelajaran berbasis pendekatan STEM melalui model PjBL yang layak digunakan untuk meningkatkan literasi sains siswa dalam pembelajaran fisika. Penelitian ini merupakan penelitian pengembangan dengan menggunakan model ADDIE yang terdiri dari lima tahap pengembangan, yaitu Analysis, Design, Development, Implementation, and Evaluation. Subjek penelitian ini adalah siswa kelas XI SMA Negeri 5 Banda Aceh. Uji lapangan pada tahap implementation menggunakan desaign penelitian eksperimen (quasi experimental design) model yang digunakan adalah non-equaivalent control group design. Instrumen penelitain berupa angket validasi, angket respon guru dan peserta didik serta soal tes kemampuan literasi sains. Hasil posttest kemampuan literasi sains peserta didik kemudian diuji menggunakan uji t untuk melihat perbedaan antara kelas eksperimen dan kelas kontrol. Berdasarkan hasil penelitian diketahui bahwa perangkat pembelajaran yang dikembangkan layak digunakan untuk meningkatkan kemampuan literasi sains peserta didik.
The association between blood heavy metals level and sex hormones among postmenopausal women in the US
Authors: Zhang Wenchao , Cui Yugui , Liu Jiayin 
Published: July 2023

IntroductionEnvironmental pollutants could be implicated in female endocrine setting Q6 beyond traditional factors. Until now, few study has focused on the association of environmental exposure to heavy metals with sex hormones in postmenopausal women. This study intended to investigate whether serum levels of heavy metals(i.e., Cd, Pb, Hg, Mn, Se) would influence sex hormones in postmenopausal women.Methods and resultsA cross-sectional study was performed on 614 nationally representative participants from 2013-2016 National Health and Nutrition Examination Survey (NHANES) in the US. Multivariate linear regression models and restricted cubic spline plots revealed cadmium(Cd) had linear positive association with TT(β=3.25, 95%CI= 1.12, 5.38), bioavailable TT(β=1.78, 95%CI=0.36,3.21) and TT/E2(β=0.76, 95%CI=0.28,1.24), which was more apparent in natural menopausal and obese women. Lead(Pb) had linear positive association with SHBG(β=12.84, 95%CI= 6.77,18.91), which was apparent in nearly all subgroups except in normal BMI group, and TT/E2 (β=0.69, 95%CI 0.134,1.25), which was apparent in natural menopausal and normal BMI women. Manganese(Mn) had non-linear association with SHBG, which was more apparent in natural menopausal and obese women, and TT/E2, which was more apparent in natural menopausal and normal BMI women. Selenium(Se) had U shaped non-linear association with TT, which was more apparent in hysterectomy, overweight and obese women, and SHBG, which was apparent in nearly all subgroups except in normal BMI group.ConclusionIn summary, this cross-sectional study indicates a possible role that various degree of environmental exposure to heavy metals plays in the disruption of sex Q5 hormone levels in postmenopausal women. Further experiments are needed to elucidate the underlying mechanisms.
Microalgae-mediated tandem culture of shrimp and bivalve: an environmental and health co-benefits solution for phosphorus recovery and emission reduction
Authors: Ma Shuonan , Dong Xumeng , Luo Cheng , Zhao Chunpu , Xu Jilin 
Published: July 2023

Phosphorus (P) accumulation in aquaculture systems is damaging our environment beyond acceptable levels. Devising strategies to potentially recover P from aquaculture systems in a reusable bioresource form is paramount and aligns with circular economy policies. In this study, we constructed two culture models, monoculture (Mon) and tandem culture (Tan), using Exopalaemon carinicauda and Mercenaria mercenaria. By monitoring the performance of rearing organisms, P dynamic patterns, and pollutant emissions, we found that: i) Compared to the Mon system, the Tan system demonstrated no differences in the performance of E. carinicauda and M. mercenaria, suggesting that the Tan model was viable in terms of fishery yield; ii) P in the Tan system could be efficiently recovered and removed from water and sediment, as indicated by the lower phosphate concentration in water (0.01 mg L−1), and the decrease in labile P in surface sediment (from 0.04 to 0.02 mg L−1). A combination of assimilatory and dissimilatory processes, mediated by phototrophic (bait-microalgae) and heterotrophic organisms (bivalves), appeared to be the primary mechanism for P utilization and removal; iii) The Tan system reduced pollutant emissions four times lower than the Mon system due to its minimal tailwater discharge (10%, 230 L). The emissions of total P, phosphate, total organic carbon, ammonium, and chemical oxygen demand from the Tan systems were 19 mg m−2 d−1, 2 mg m−2 d−1, 2 g m−2 d−1, 38 mg m−2 d−1, and 11 g m−2 d−1, respectively, 1.3, 1.7, 1.4, 1.3, and 1.2 times lower than those from the Mon systems. The eco-friendly Tan culture model fully exploited the resources of pond culture, a solution with environmental and health co-benefits for P recovery and emission reduction.