bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breaking Consecutive Hydrogen‐Bond Network Toward High‐Rate Hydrous Organic Zinc Batteries
Authors: Cui Changjun , Han Daliang , Lu Haotian , Li Zhiguo , Zhang Kangyu , Zhang Bo , Guo Xiaoxia , Sun Rui , Ye Xiaolin , Gao Jiachen , Liu Yingxin , Guo Yong , Meng Rongwei , Wei Chunguang , Yin Lichang , Kang Feiyu , Weng Zhe , Yang Quan‐Hong 
Published: June 2023

AbstractZinc batteries hold great potential for stationary energy storage but suffer from severe dendrite growth, corrosion, and hydrogen evolution troubles in aqueous electrolytes. Despite the impressive efficacy of non‐flammable hydrous organic electrolytes in addressing these problems, the insufficient ionic conductivity hinders the rate capability and practicability of hydrous organic Zn batteries. Here, methanol is proposed as a co‐solvent for ethylene glycol (EG)‐based hydrous organic electrolytes, where its methyl terminal group can interrupt the continuous intermolecular hydrogen bond network among EG. The new hydrous organic electrolyte exhibits a doubled ionic conductivity without sacrificing the exceptional nonflammability. As a result, the Zn anode exhibits a long‐term cycling stability over 4000 h at 0.5 mA cm−2, a high Coulombic efficiency of 99.5%, high‐rate capability up to 20 mA cm‒2, and impressive low‐temperature tolerance of ‒60 °C. The Zn||V2O5 pouch cell with the electrolyte is capable of operating under extreme operation conditions involving needling, package breakage, and even exposure to fire. This work paves an avenue toward electrolyte design for high‐rate practical Zn batteries and beyond.
A Network Imaging Biomarker of X‐Linked Dystonia‐Parkinsonism
Authors: Niethammer Martin , Tang Chris C. , Jamora Roland Dominic G. , Vo An , Nguyen Nha , Ma Yilong , Peng Shichun , Waugh Jeff L. , Westenberger Ana , Eidelberg David 
Published: June 2023

ObjectiveThe purpose of this study was to characterize a metabolic brain network associated with X‐linked dystonia‐parkinsonism (XDP).MethodsThirty right‐handed Filipino men with XDP (age = 44.4 ± 8.5 years) and 30 XDP‐causing mutation negative healthy men from the same population (age = 37.4 ± 10.5 years) underwent [18F]‐fluorodeoxyglucose positron emission tomography. Scans were analyzed using spatial covariance mapping to identify a significant XDP‐related metabolic pattern (XDPRP). Patients were rated clinically at the time of imaging according to the XDP‐Movement Disorder Society of the Philippines (MDSP) scale.ResultsWe identified a significant XDPRP topography from 15 randomly selected subjects with XDP and 15 control subjects. This pattern was characterized by bilateral metabolic reductions in caudate/putamen, frontal operculum, and cingulate cortex, with relative increases in the bilateral somatosensory cortex and cerebellar vermis. Age‐corrected expression of XDPRP was significantly elevated (p < 0.0001) in XDP compared to controls in the derivation set and in the remaining 15 patients (testing set). We validated the XDPRP topography by identifying a similar pattern in the original testing set (r = 0.90, p < 0.0001; voxel‐wise correlation between both patterns). Significant correlations between XDPRP expression and clinical ratings for parkinsonism—but not dystonia—were observed in both XDP groups. Further network analysis revealed abnormalities of information transfer through the XDPRP space, with loss of normal connectivity and gain of abnormal functional connections linking network nodes with outside brain regions.InterpretationXDP is associated with a characteristic metabolic network associated with abnormal functional connectivity among the basal ganglia, thalamus, motor regions, and cerebellum. Clinical signs may relate to faulty information transfer through the network to outside brain regions. ANN NEUROL 2023;94:684–695
Safety and immunogenicity of a third dose of mRNA‐1273 vaccine among cancer patients
Authors: Giuliano Anna , Kuter Barbara , Pilon‐Thomas Shari , Whiting Junmin , Mo Qianxing , Leav Brett , Sirak Bradley , Cubitt Christopher , Dukes Christopher , Isaacs‐Soriano Kimberly , Kennedy Kayoko , Ball Somedeb , Dong Ning , Jain Akriti , Hwu Patrick , Lancet Jeffrey 
Published: June 2023

AbstractBackgroundCompared to the general population, cancer patients are at higher risk of morbidity and mortality following SARS‐CoV‐2 infection. The immune response to a two‐dose regimen of mRNA vaccines in cancer patients is generally lower than in immunocompetent individuals. Booster doses may meaningfully augment immune response in this population. We conducted an observational study with the primary objective of determining the immunogenicity of vaccine dose three (100 μg) of mRNA‐1273 among cancer patients and a secondary objective of evaluating safety at 14 and 28 days.MethodsThe mRNA‐1273 vaccine was administered ∼7 to 9 months after administering two vaccine doses (i.e., the primary series). Immune responses (enzyme‐linked immunosorbent assay [ELISA]) were assessed 28 days post‐dose three. Adverse events were collected at days 14 (± 5) and 28 (+5) post‐dose three. Fisher exact or X2 tests were used to compare SARS‐CoV‐2 antibody positivity rates, and paired t‐tests were used to compare SARS‐CoV‐2 antibody geometric mean titers (GMTs) across different time intervals.ResultsAmong 284 adults diagnosed with solid tumors or hematologic malignancies, dose three of mRNA‐1273 increased the percentage of patients seropositive for SARS‐CoV‐2 antibody from 81.7% pre‐dose three to 94.4% 28 days post‐dose three. GMTs increased 19.0‐fold (15.8‐22.8). Patients with lymphoid cancers or solid tumors had the lowest and highest antibody titers post–dose three, respectively. Antibody responses after dose three were reduced among those who received anti‐CD20 antibody treatment, had lower total lymphocyte counts and received anticancer therapy within 3 months. Among patients seronegative for SARS‐CoV‐2 antibody pre‐dose three, 69.2% seroconverted after dose three. A majority (70.4%) experienced mostly mild, transient adverse reactions within 14 days of dose three, whereas severe treatment‐emergent events within 28 days were very rare (<2%).ConclusionDose three of the mRNA‐1273 vaccine was well‐tolerated and augmented SARS‐CoV‐2 seropositivity in cancer patients, especially those who did not seroconvert post–dose two or whose GMTs significantly waned post–dose two. Lymphoid cancer patients experienced lower humoral responses to dose three of the mRNA‐1273 vaccine, suggesting that timely access to boosters is important for this population.
Dust‐ion‐acoustic shock wave excitations at super‐critical points with quartic nonlinearity
Authors: Akter Parvin , Hafez M. G. 
Published: June 2023

AbstractProgress in understanding the propagation of dust ion acoustic shock waves for the super critical values of any specific parameter which accompany an unmagnetized collisionless four‐component dusty multi‐ion nonextensive plasma is presented. To accomplish this goal, the formation of modified Burgers‐type equation having quartic nonlinearity via the reductive perturbation method and its analytical solution is yielded for the first time. It is found that the compressive electrostatic shocks are supported not only around the super critical values but also at the super critical values of the specific parameters. The presented results would be applicable to comprehend wave propagation in interplanetary plasmas and laboratory plasmas.
Take me for a ride: Herbivores can facilitate plant reinvasions
Authors: Sullivan Lauren L. , Shaw Allison K. 
Published: June 2023

AbstractHerbivores shape plant invasions through impacts on demography and dispersal, yet only demographic mechanisms are well understood. Although herbivores negatively impact demography by definition, they can affect dispersal either negatively (e.g., seed consumption), or positively (e.g., caching). Exploring the nuances of how herbivores influence spatial spread will improve the forecasting of plant movement on the landscape. Here, we aim to understand how herbivores impact how fast plant populations spread through varying impacts on plant demography and dispersal. We strive to determine whether, and under what conditions, we see net positive effects of herbivores, in order to find scenarios where herbivores can help to promote spread. We draw on classic invasion theory to develop a stage‐structured integrodifference equation model that incorporates herbivore impacts on plant demography and dispersal. We simulate seven herbivore “syndromes” (combinations of demographic and/or dispersal effects) drawn from the literature to understand how increasing herbivore pressure alters plant spreading speed. We find that herbivores with solely negative effects on plant demography or dispersal always slow plant spreading speed, and that the speed slows monotonically as herbivore pressure increases. However, we also find that plant spreading speed can be hump shaped with respect to herbivore pressure: plants spread faster in the presence of herbivores (for low herbivore pressure) and then slower (for high herbivore pressure). This result is robust, occurring across all syndromes in which herbivores have a positive effect on plant dispersal, and is a sign that the positive effects of herbivores on dispersal can outweigh their negative effects on demography. For all syndromes we find that sufficiently high herbivore pressure results in population collapse. Thus, our findings show that herbivores can speed up or slow down plant spread. These insights allow for a greater understanding of how to slow invasions, facilitate native species recolonization, and shape range shifts with global change.
Cardiovascular health‐related quality of life in cancer: a prospective study comparing the ESC HeartQoL and EORTC QLQ‐C30 questionnaire
Authors: Anker Markus S. , Potthoff Sophia K. , Lena Alessia , Porthun Jan , Hadzibegovic Sara , Evertz Ruben , Denecke Corinna , Fröhlich Ann‐Kathrin , Sonntag Frederike , Regitz‐Zagrosek Vera , Rosen Stuart D. , Lyon Alexander R. , Lüscher Thomas F. , Spertus John A. , Anker Stefan D. , Karakas Mahir , Bullinger Lars , Keller Ulrich , Landmesser Ulf , Butler Javed , von Haehling Stephan 
Published: June 2023

AbstractAimsHealth‐related quality of life (HRQoL) is highly relevant in cancer and often assessed with the EORTC QLQ‐C30. Cardiovascular HRQoL in cancer can be measured with the ESC HeartQoL questionnaire. We compared these instruments and examined their prognostic value.Methods and resultsSummary scores for EORTC QLQ‐C30 (0–100 points) and ESC HeartQoL (0–3 points) questionnaires were prospectively assessed in 290 patients with mostly advanced cancer (stage 3/4: 81%, 1‐year mortality: 36%) and 50 healthy controls (similar age and sex). Additionally, physical function and activity assessments were performed. Both questionnaires demonstrated reduced HRQoL in patients with cancer versus controls (EORTC QLQ‐C30: 67 ± 20 vs. 91 ± 11, p < 0.001; ESC HeartQoL: 1.8 ± 0.8 vs. 2.7 ± 0.4, p < 0.001). The instruments were strongly correlated with each other (summary scores [r = 0.76], physical [r = 0.81], and emotional subscales [r = 0.75, all p < 0.001]) and independently associated with all‐cause mortality (best cut‐offs: EORTC QLQ‐C30 <82.69: hazard ratio [HR] 2.33, p = 0.004; ESC HeartQoL <1.50: HR 1.85, p = 0.004 – adjusted for sex, age, left ventricular ejection fraction, N‐terminal pro‐B‐type natriuretic peptide [NT‐proBNP], high‐sensitivity troponin T, cancer stage/type), with no differences in the strength of the association by sex (p‐interaction > 0.9). Combining both questionnaires identified three risk groups with highest mortality in patients below both cut‐offs (vs. patients above both cut‐offs: HR 3.60, p < 0.001). Patients with results below both cut‐offs, showed higher NT‐proBNP and reduced physical function and activity.ConclusionsThe EORTC QLQ‐C30 and ESC HeartQoL – assessing cancer and cardiovascular HRQoL – are both associated with increased mortality in cancer patients, with even greater stratification by combing both. Reduced HRQoL scores were associated with elevated cardiovascular biomarkers and decreased functional status.
Intra‐ and interindividual reliability of muscle pain induced by an intramuscular injection of hypertonic saline injection into the quadriceps
Authors: Smith Samuel A. , Norbury Ryan , Hunt Adam J. , Mauger Alexis R. 
Published: June 2023

AbstractBackgroundIntramuscular injections of hypertonic saline are commonly used to induce experimental muscle pain, but reliability data on this technique are lacking. This study investigated the intra‐ and interindividual reliability of pain measures from a hypertonic saline injection into the vastus lateralis.MethodsFourteen healthy participants (6 female) attended three laboratory visits where they received an intramuscular injection of 1 mL hypertonic saline into the vastus lateralis. Changes in pain intensity were recorded on an electronic visual analogue scale, and pain quality was assessed after pain had resolved. Reliability was assessed with the coefficient of variation (CV), minimum detectable change (MDC) and intraclass correlation coefficient (ICC) with 95% CIs.ResultsMean pain intensity displayed high levels of intraindividual variability (CV = 16.3 [10.5–22.0]%) and ‘poor’ to ‘very good’ relative reliability (ICC = 0.71 [0.45–0.88]) but had a MDC of 11 [8–16] au (out of 100). Peak pain intensity exhibited high levels of intraindividual variability (CV = 14.8 [8.8–20.8]%) with ‘moderate’ to ‘excellent’ levels of relative reliability (ICC = 0.81 [0.62–0.92]), whereas the MDC was 18 [14–26] au. Measures of pain quality exhibited good reliability. Interindividual variability in pain measures was high (CV > 37%).ConclusionsIntramuscular injections of 1 mL of hypertonic saline into the vastus lateralis display substantial levels of interindividual variability, but MDC is below the clinically important changes in pain. This model of experimental pain is suitable for studies involving repeated exposures.SignificanceMany pain research studies have performed intramuscular injections of hypertonic saline to investigate responses to muscle pain. However, the reliability of this technique is not well established. We examined the pain response over three repeated sessions of a hypertonic saline injection. The pain induced by hypertonic saline has considerable interindividual variability but has largely acceptable intraindividual reliability. Therefore, the injections of hypertonic saline to induce muscle pain are a reliable model of experimental muscle pain.
Mitochondrial DNA control region typing from highly degraded skeletal remains by single‐multiplex next‐generation sequencing
Authors: Vinueza‐Espinosa Diana C. , Cuesta‐Aguirre Daniel R. , Malgosa Assumpció , Santos Cristina 
Published: June 2023

AbstractPoor nuclear DNA preservation from highly degraded skeletal remains is the most limiting factor for the genetic identification of individuals. Mitochondrial DNA (mtDNA) typing, and especially of the control region (CR), using next‐generation sequencing (NGS), enables retrieval of valuable genetic information in forensic contexts where highly degraded human skeletal remains are the only source of genetic material. Currently, NGS commercial kits can type all mtDNA‐CR in fewer steps than the conventional Sanger technique. The PowerSeq CRM Nested System kit (Promega Corporation) employs a nested multiplex‐polymerase chain reaction (PCR) strategy to amplify and index all mtDNA‐CR in a single reaction. Our study analyzes the success of mtDNA‐CR typing of highly degraded human skeletons using the PowerSeq CRM Nested System kit. We used samples from 41 individuals from different time periods to test three protocols (M1, M2, and M3) based on modifications of PCR conditions. To analyze the detected variants, two bioinformatic procedures were compared: an in‐house pipeline and the GeneMarker HTS software. The results showed that many samples were not analyzed when the standard protocol (M1) was used. In contrast, the M3 protocol, which includes 35 PCR cycles and longer denaturation and extension steps, successfully recovered the mtDNA‐CR from highly degraded skeletal samples. Mixed base profiles and the percentage of damaged reads were both indicators of possible contamination and can provide better results if used together. Furthermore, our freely available in‐house pipeline can provide variants concordant with the forensic software.
Subcritical hydrothermal purification from oily sludge recovered from petroleum oily sludge by adding sodium hydroxide, sodium bicarbonate, and formic acid
Authors: Duan Yuanwang , Wang Shuzhong , He Chao , Zhang Fan , Liu Rentong , Li Yanhui , Wang Yulong , Zhang Lanxin 
Published: June 2023

AbstractSubcritical water upgrading has received a great deal of attention because of its high efficiency and environmental protection technology features, but its high temperature and high‐pressure reaction conditions have limited its further development. This article investigates the hydrothermal upgrading recovered oil from oily sludge at 350°C and for a residence time of 60 min recovered oil. The effects of the type and concentration of various additives sodium hydroxide (NaOH), sodium bicarbonate (NaHCO3) and formic acid (CH3COOH) on the yield and quality of recovered oil were analyzed and discussed. The addition of 2 wt % NaOH increases the recovered oil yield to 78.6%, due to the demulsification effect of alkaline additives. Meanwhile, the CH3COOH effectively increased the H/C ratio of the recovered oil to 1.69, which can be attributed to the hydrogenation of large molecules in the sludge with hydrogen generated from the added CH3COOH. The effect characteristics and mechanisms of adding additives on the increase in the recovered oil yield and quality of oil‐bearing sludge in a sub‐critical hydrothermal environment were revealed. Subcritical water upgrading technology provides a new technological route for resource recovery of oily sludge with mild reaction conditions and high efficiency and simplicity.
Planar frame models considering system‐level interactions of a two‐story low‐damage concrete wall building
Authors: Gu Anqi , Zhou Ying , Lu Yiqiu , Yang Qun , Henry Richard S. , Rodgers Geoffrey W. 
Published: June 2023

AbstractA system‐level shake‐table test of a two‐story low‐damage concrete wall building was conducted in 2019. The test building consisted of unbonded post‐tensioned (UPT) walls with perimeter frames and different wall‐to‐floor connections to provide deformation compatibility. The test results highlighted that the measured lateral strength of the building notably exceeded the design value. This over‐strength was largely attributed to the compatibility deformations imposed on the floor systems. Previous simulation results from planar models also underestimated the building global response and lateral strength, so a modified model was developed to improve the accuracy by accounting for the system‐level interactions. The floor slab out‐of‐plane strength was assessed by the floor slab models using shell elements to quantify their response when subjected to deformations induced by the UPT wall uplift. In addition, the unintended effects of the beam‐to‐floor connection strength were also calculated. The strength contributions from the floor and connections were included in the planar frame models using lumped rotational springs located at the slotted‐beam joints. Lastly, the models were also updated to include flexibility in the connections of the energy dissipations at the wall bases based on test observations. Nonlinear time history analysis of the updated models for unidirectional loading cases demonstrated an improved calculation of the test results for both the global and local responses. When considering the floor interaction in the updated models, the absolute relative errors of peak overturning moments reduced from 35.4% to 15.6% averagely for the longitudinal direction, and from 23.1% to 14.1% averagely for the transverse direction.
Unreliable determination of in situ stress orientation by cross multipole array acoustic logging in fractured shale reservoirs
Authors: Yang Haimeng , Yu Jifeng , Liu Jingshou , Hu Caifu , Zhang Binxin , Chen Peng 
Published: June 2023

AbstractWith the development of shale gas exploration in China, the use of conventional logging tools has been introduced, and cross multipole array acoustic logging tools have gradually been used to determine the stress orientation in shale. The direction of fast shear waves (FSWs) is generally parallel to the horizontal maximum principal compression stress (SHmax). However, the azimuth of FSWs is found to be parallel to the main strike (but not to the SHmax) direction of structural fractures in shale reservoirs. Outcrop and image logging data indicate that the natural fractures in this area strike NE‒SW. If the shear wave anisotropy is caused by only the stress around the borehole and the FSWs are known to be NE‒SW, SHmaxshould be parallel to NE‒SW; however, according to statistics of land movement in adjacent areas, anelastic strain recovery, earthquake focal mechanism, borehole breakouts, hydraulic fracturing data, deviated well data, and drilling‐induced fracture data in local regions, SHmaxis oriented in the NW‒SE direction, and the directions of FSWs are generally parallel to the structural fracture direction. This contradiction indicates that the development of structural fractures may affect the orientation of FSWs. Therefore, it is not reliable to use XMAC (Cross‐Multipole Array Acoustilog) logging only to determine the direction of in situ stress in fractured shale reservoirs. In addition, the direction of the FSWs in the middle of thick mudstones is NW‒SE, which may represent accurate information about the in situ stress direction.
Gastrochilus flabelliformis (Blatt. & McCann) C.J.Saldanha (Epidendroideae: Vandeae: Aeridinae), an addition to the orchid flora of Sri Lanka, with taxonomic notes on Gastrochilus dasypogon (Sm.) Kuntze
Authors: Amerasinghe Kumudu , Weerasinghe Nadeera , Abeysinghe Muditha , Bandara Champika , Wojtas K. Philip , Kumar Pankaj 
Published: June 2023

AbstractGastrochilus flabelliformis (Blatt. & McCann) C.J.Saldanha is added to the orchid flora of Sri Lanka from the lowland intermediate zone and G. obliquus (Lindl.) Kuntze is omitted from the list. A detailed taxonomic description, color plates, and line drawings with habitat ecology and distribution are provided for the former. Taxonomic notes on the identity of true Gastrochilus dasypogon (Sm.) Kuntze are also discussed in this paper, resulting in the merger of G. acutifolius (≡S. acutifolium), G. denticulatus (≡S. denticulatum), and G. dentatus (≡S. dentatum) under the synonymy of the former.