bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alpha Cell Stimulus-Secretion Coupling and Intercellular Interactions in Health and Type 2 Diabetes
Authors: Pohorec Viljem , Zadravec Nika , Turk Marko , Dolenšek Jurij , Stožer Andraž 
Published: July 2023

Beta cell dysfunction has long been thought to be at the root of type 2 diabetes pathogenesis; however, a bi-hormonal model of the disease appears to be more realistic. Alpha cells play a significant role in glucose homeostasis due to their communication with other cells within the islets of Langerhans and tissues like the liver through glucagon action. Although a concise model of their physiology is still lacking, new approaches provide more insight into the pathways of glucagon secretion and processes regulating it, which gives insight into alpha cell function in health and disease, with potential implications for type 2 diabetes management.
Impacts of the 2019 pandemic of severe acute respiratory syndrome–coronavirus 2 on the quality of life of patients with inflammatory rheumatic diseases
Authors: Lah Domen , Holc Iztok 
Published: July 2023

Purpose: The aim of this study was to assess the impact of the SARS-CoV-2 pandemic and protective measures on the QoL of patients with inflammatory rheumatic diseases (IRDs) who received treatment at the Department of Rheumatology at the University Medical Centre Maribor (UCM-MB).
Methods: A questionnaire was sent to IRD patients who visited a rheumatology outpatient clinic or were contacted by phone or virtually at least once between February 1, 2020 and May 30, 2021. The questionnaires were included if returned to UCM-MB by January 1, 2022 and were completed correctly and in full.
Results: Of the 125 patients who met the inclusion criteria, 57 (45.6%) had no cancelled rheumatology appointments, 52 (41.6%) had one, 15 (12.0%) had two, and one patient (0.8%) had three. The most preferred mode of communication was in-person meetings with a rheumatologist (89%) and the least was a video call (1%). Only 2% of patients had problems obtaining medication during the pandemic, but none reported consequences with disease status. More than half (58%) of patients agreed with the restrictions during the pandemic and 5% stated the restrictions should be terminated. Most (70%) patients were vaccinated against SARS-CoV-2 and 21% reported SARS-CoV-2 infection. The mean disease activity score (DAS-28) was 3.100 ± 1.292 (rheumatoid arthritis, 3.252 ± 1.209; psoriatic arthritis, 2.927 ± 1.376; p = 0.274; t = 1.101).
Conclusion: The pandemic and associated protective measures had deleterious effects on the QoL of IRD patients.
Different Psychological Processes in Traditional and ACT-Enhanced ERP for Obsessive-Compulsive Disorder
Authors: Buchholz Jennifer L. , Abramowitz Jonathan S. , Hellberg Samantha N. , Ojalehto Heidi J. , Twohig Michael 
Published: July 2023

Background:Acceptance and commitment therapy (ACT) has been shown to promote willingness to experience intrusive thoughts among individuals with obsessive-compulsive disorder (OCD). Exposure with response prevention (ERP) delivered from an ACT framework (i.e., ACT+ERP) may facilitate changes in how patients relate to their unwanted internal experiences.Aims:Accordingly, the present study aimed to examine the effect of ACT+ERP on appraisals of intrusive thoughts, relative to standard ERP.Methods:Forty-eight adults who received 16 treatment sessions as part of a randomized controlled trial comparing standard ERP to ACT+ERP completed the Interpretation of Intrusions Inventory (III) at pre-treatment, post-treatment, and follow-up.Results:Results showed a significant main effect of time for all III subscales, suggesting that appraisals of intrusive thoughts shift over the course of treatment. The effect of the condition × time interaction, however, differed between the III subscales. Specifically, a significant interaction emerged for the control of thoughts subscale, such that individuals who received ACT+ERP experienced greater reductions in beliefs about the need to control thoughts. The interaction term was not significant for importance of thoughts or responsibility subscales.Conclusions:Findings suggest that augmenting ERP with ACT enhances change in beliefs about the need to control thoughts, but not in beliefs about responsibility and the importance of thoughts. Clinical implications and future research directions will be discussed.
Analyticity and uniqueness of the fractional electromagnetic BVP
Authors: ALi Ahmed Refaie 
Published: July 2023

Abstract
This paper presents a novel investigation that establishes the uniqueness and analyticity of the fractional solution to a fractional electromagnetic boundary value problem (BVP). The BVP is defined by specifying the tangential electromagnetic components. It has been proven that the analytical expressions for the fractional electromagnetic fields Eα, E*α, Hα, and H*α do not vanish in any subregions Ωαo or Ωα - Ωαo. Furthermore, the unique solution makes Eα= E*α and Hα= and H*α without singular fields at same region of the space. Analyticity of the fractional time-harmonic electromagnetic field within lossy or lossless dielectric regions is proven. This paper is generalization of works [2,4] and [24,25].
Research on Bionic Design of Cylindrical Milling Cutter Based on the Curvilinear Configuration of the Rake Face of Beaver Teeth
Authors: lei chao , Xie Feng , Wu Fangchao , Yan Qiang 
Published: July 2023

Abstract
Bionic design of cutting tools to reduce working resistance and energy consumption has always been a concern of people. The curve of the rake face of beaver teeth is fitted and its general expression is obtained. The function is used in the configuration design of the bionic alignment of the front cutter face of cylindrical milling cutter, and the bionic curvilinear configuration rake face cylindrical milling cutter is designed. By constructing a three-dimensional milling simulation model of a cylindrical milling cutter, the cutting performance of a cylindrical milling cutter with a bionic collinear configuration and a cylindrical milling cutter with a flat front face was analyzed by comparing the milling simulation with a cylindrical milling cutter with a bionic collinear configuration composed of different combinations of front face collinear parameter values. The results show that the designed bionic collinear configuration front face cylindrical milling cutter exhibits certain force saving effect and is verified by right angle free cutting experiments, but its drag reduction performance is affected by the parameter values of the collinear. The optimized parameter values of the front face collinear of the tool with a certain side draft are obtained by genetic algorithm combined with finite element simulation analysis, and the optimal combination of collinear parameter values is obtained.
Depletion of Muscularis Macrophages Ameliorates Inflammation- driven Dysmotility in Murine Colitis Model
Authors: Ferenczi Szilamer , Mogor Fruzsina , Takacs Peter , Kovacs Tamas , Toth Viktoria E. , Varga Zoltan V. , Kovacs Krisztina , Lohinai Zoltan , Nagy Nandor , Dora David 
Published: July 2023

Abstract
Previously, the presence of a blood-myenteric plexus barrier and its disruption was reported in experimentally induced colitis via a macrophage-dependent process. The aim of this study is to reveal how myenteric barrier disruption and subsequent neuronal injury affects gut motility in vivo in a murine colitis model. We induced experimental colitis with dextran sulfate sodium (DSS), with the co-administration of liposome-encapsulated clodronate (L-clodronate) to deplete muscularis macrophages (MMs) in male mice. DSS-treated animals receiving concurrent L-clodronate injection showed significantly decreased MM-density compared to DSS-treated control (DSS-vehicle). DSS-clodronate-treated mice exhibited significantly slower whole gut transit time than DSS-vehicle-treated animals and comparable to that of controls. Experiments with oral gavage-fed Evans-blue dye show similar whole gut transit times in DSS-clodronate-treated mice as in control animals. Furthermore, qPCR-analysis on colon muscularis samples revealed that factors associated with neuroinflammation and neurodegeneration are overexpressed after DSS-treatment, but not in the case of concurrent L-clodronate administration. Our findings highlight that MM-infiltration in the muscularis layer is responsible for colitis-associated dysmotility and enteric neuronal dysfunction along with the release of mediators associated with neurodegeneration in a murine experimental model.
Determining the role of innovative teaching practices, sustainable learning, and the adoption of e-learning tools in leveraging academic motivation for students' mental well-being.
Authors: Li Jiuxiang , Wang Rufeng 
Published: July 2023

Abstract
Background
The COVID-19 pandemic has brought about significant changes in the educational landscape, with a significant shift towards e-learning and remote teaching practices. As such, it has become increasingly important to understand the role of innovative teaching practices, sustainable learning, and the adoption of e-learning tools in leveraging academic motivation for students' mental well-being.
Purpose
The study aims to determine whether academic motivation can helpful for mental wellbeing of students directly and through the adoption of e-learning tools, and sustainable learning considering the role of innovative teaching.
Methods
Target population of this research were the students of Chinese universities. Data was collected from 308 students and was analyzed by using Mplus software.
Results
Students expressed higher motivation, quality education and good mental health. Additionally, it was discovered that academic motivation helped the students to develop good academic record and mental health.
Conclusion
The research's conclusions can help the policy makers creating successful educational initiatives and programs that promote students' overall growth. These results can also guide the university administration and teachers to adopt effective policies and practices for creating academic motivation in order to construct a healthy environment not just for better academic results but also for the well-being of students. Additionally, this research draws attention of future researchers to explore mechanisms that can drive students’ academic and psychological outcomes.
Who stays engaged in long term follow up studies? A study of adolescent retention across 7 years.
Authors: Furneaux-Bate Ainsley , Bryant Zachary , Newton Nicola , Slade Tim , Teesson Maree , Chapman Cath , Mewton Louise , Ellem Rhiannon , Catakovic Amra , Hides Leanne , McBride Nyanda , Allsop Steve , Baker Megan , Niklasson Lena , Chatterton Mary Lou , Birrell Louise 
Published: July 2023

Abstract
Background
Mental health and substance use disorders typically emerge early in life with impacts extending into early adulthood. Longitudinal studies are well-placed to investigate the progression of mental health and substance use disorders in adolescents. However, a significant challenge of longitudinal studies is sample attrition, or failure to retain participants. The impact of attrition may be reduced by understanding factors related to drop out, which can then be mitigated through optimised research design. To date, there remains a gap in the literature in determining characteristics of adolescent participants that are associated retention in school-based studies.
Methods
This paper aimed to; (1) investigate the baseline characteristics of adolescent participants who are retained in long-term follow-up research, and (2) retrospectively explore the effectiveness of methods used to retain adolescents in long-term follow up. Data from the Climate Schools Combined (CSC) study was used to understand which baseline participant characteristics predicted retention at either 60- and 72-month long term follow-up occasions. Of the 5,417 eligible participants, 1877 (34.65%; 61.40% female) were retained at either the 5- or 6-year post-baseline survey occasion. On average, participants were aged 18.5 years (SD = 0.60) at the 5-year follow-up and 19.9 years (SD = 0.50) at the 6-year follow-up.
Results
Being female (OR = 1.22, [1.03–1.45]), reporting grades between 80–89% (OR = 2.01, [1.21–3.32]) and 90–100% (OR = 2.41, [1.46–3.98]), higher self-reported depression (PHQ) scores (OR = 1.03, [1.02–1.05]) and higher mental health knowledge scores (OR = 1.08, [1.05–1.11]) at baseline were significant predictors of participant retention in long term follow-up.
Conclusions
Longitudinal clinical trial research is key to better understanding trajectories of mental health and substance use and the durability of prevention programs. Researchers need to be aware of the constantly changing technological landscape, including social media and shifting privacy policies, that may impact the ability to contact study participants. Researchers should consider these factors when designing retention strategies for groups that are more likely to drop out if they are to minimise the impact of missing data on results. This paper has outlined several practical strategies that can be implemented in future research trials.
Comparison of wire-guided localization (WGL) and radio-guided occult lesion localization(ROLL) in localization of non-palpable breast lesions
Authors: elzohery Yasmine hany abd el moamen , gomaa Mohammed Mohammed , abdelsalam ghada mohamed , fadlalla waleed Mohamed , taha sherif Nasser , ibraheem maher Hassan 
Published: July 2023

Abstract
Background:
The number of patients with non-palpable breast lesions has increased gradually. This is because of the technological development in imaging techniques and the screening programs that lead to early detection of breast lesions.
The aim of marking the non-palpable breast lesions is to achieve accurate lesion localization, to obtain the better cosmetic result with less tissue loss and to provide negative surgical margin.
Aim:the aim of the study is to compare the wire-guided localization (WGL) technique with the radioguided occult lesion localization (ROLL) technique to assess their accuracy and efficacy in non-palpable breast lesions localization.
Methods:From January 2018 and June2022 a total of 670 patients underwent an excision for non-palpable lesions were enrolled randomly in ROLL group (n = 320 ) and WGL (n =350 ) at Baheya center for Early Detection and Treatment of Breast Cancer.
Results: There were no differences between the two groups in terms of age, localization technique.Both the localization time and the time of operation were decreased with the ROLL. Complete lesion excision with clear margins were reported in (88.2%) of ROLL patients and in (81.8%) of WGL patients. Reoperations were done as a second operation on16( 11.8%)of ROLL patients and on 29( 18.2%) of WGL patients.
Conclusion:This study shows that ROLL is as effective as WGL for non-palpable breast lesions excision. Also, ROLL improve the outcomes by decreasing the duration of surgery, localization time,achieving a higher percentage of clear margin in spite of lower specimen size and scar length.
Relationship between fungal bioaerosols and biotic stress on crops – A case study on wheat rust fungi
Authors: Varghese Emil , Krishnamoorthy Sarayu , Patel Ankit , Thazhekomat Hredhya , Kumari Kiran , Bhattacharya Bimal K , Kundu Shyam S , Goswami Jonali , Verma Rama Shanker , Raghunathan Ravikrishna , Yadav Shweta , Gunthe Sachin S 
Published: July 2023

Abstract
This study proposes the relationship between fungal bioaerosols and biotic stress on crops using a case study on wheat leaf rust reported from northern India. We sampled and quantified the size-resolved fungal bioaerosols using the Next-Generation Sequencing technique from a wheat crop field during winter. Puccinia recondita, the fungal pathogen that causes wheat leaf rust, was identified during the study period. The pathogen is known for its frequent and widespread occurrence of new variants that causes disease-resistant crop varieties susceptible to infections. This reveals the need for frequent and systematic monitoring to prevent rust infection. In the current study, the size-resolved fungal bioaerosol characterisation was linked to the dispersal properties of the fungal propagules, and using a theoretical dispersion model, originating source and the areas of high risk for wheat leaf rust infection were identified. Our findings may serve as a vital reference for crop pathologists, agro technologists, environmentalists, and policymakers to expand the investigation on the biotic stress caused by the invasion of fungal bioaerosols on various crops and to implement preventive measures to ensure global food security.
Second-order calibration-assisted excitation-emission matrix fluorescence detection of multi-class mycotoxins in grape, wine and raisin for food safety risk assessment
Authors: Yao Zhang , Qian Ge , Yi Lv , Shuannan Xie , Jiaojiao Huang , Lijin Ma , Chao Tang , Zhi Liu , Guolong Wu 
Published: July 2023

Abstract
Mycotoxin risks in grape and its products (wine, raisin) are widely concerned food safety issues, it closely associated with consumers’ health. In this study, an analytical strategy by combining second-order calibration method with excitation-emission matrix (EEM) fluorescence detection followed photo derivatization (PD) was explored for rapid and sensitive analysis of aflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEA) in grape, raisin and wine. Except simple solvent extraction by ethyl acetate and concentration by vacuum distillation, samples don’t need other complicated treatment steps any more. With the aid of predominant second-order advantages of alternative trilinear decomposition (ATLD) algorithm, ‘pure’ spectra and quantitative signals of targeted mycotoxins can be resolved from the heavily interfered EEM profile of sample even in the presence of spectral overlaps and unknown backgrounds. The recoveries of AFB1, OTA and ZEA in four kinds of samples are in the range of 90–110%, the limits of detection (LODs) were low to 0.1 µg kg− 1, 0.5 µg kg− 1 and 0.8 µg kg− 1, respectively. This analytical strategy may be as an alternative method for improving mycotoxin analysis in complex food matrices and ensuring food safety in grape industry.
Preservation vs. Dissection of Inferior Pulmonary Ligament for Thoracoscopic Upper Lobectomy: A Prospective Randomized Controlled Trial
Authors: Qian Jiekun , Cai Shixian , Lin Pinghua , Chi Wanzhong , Chen Chun , Xu Guobin , Xu Chi , Wu Weidong , Zheng Wei , Zheng Bin 
Published: July 2023

Abstract
OBJECTIVES
The proper procedure for inferior pulmonary ligament (IPL) during upper lobectomy remains a topic of debate. To investigate this issue, we conducted an open, multicenter prospective randomized controlled trial comparing the clinical effects of preserving IPL versus dissecting IPL during thoracoscopic upper lobectomy.
METHODS
Patients undergoing thoracoscopic left/right upper lobectomy were assigned to either the dissection group (Group D) or the preserved group (Group P). Our primary purpose lay in measuring and contrasting the change of postoperative residual bronchial angle change, postoperative lung volume change, and other intraoperative and postoperative outcomes between the two groups.
RESULTS
Our findings revealed that in thoracoscopic left upper lobectomy, Group P was able to reduce the degree of postoperative residual bronchial angle change at 3 and 6 months after surgery, as compared to Group D, with a significant difference (P < 0.05). IPL preservation during thoracoscopic left upper lobectomy can therefore reduce the movement of the left residual bronchus.
CONCLUSIONS
Our study suggests that it makes no sense to dissect IPL since its dissection is of no benefit. These findings have important implications for the clinical management of patients undergoing upper lobectomy.
Parents’ Self-Compassion as a Moderator Between Children’s Emotional Regulation Difficulties and Parents’ Depressive Symptoms
Authors: Larrucea-Iruretagoyena Maite , Orue Izaskun , Calvete Esther 
Published: July 2023

Abstract
Background: Recent studies suggest that children’s emotional difficulties may impact their parents’ psychological well-being, and certain protective factors could mitigate this association. The existing literature points to self-compassion as a potential protective factor against stress and difficulties. Therefore, the present study aims to analyze the protective role of parents’ self-compassion in the predictive association between children’s emotional regulation difficulties and parents’ depressive symptoms.
Methods: A total of 214 children (53.3% girls) and their parents (209 mothers and 181 fathers) answered self-report questionnaires in a two-wave longitudinal study conducted over one year. A multilevel analysis was performed to examine the predictive pathways from children’s emotional regulation difficulties, parents’ self-compassion, and their interaction to parents’ depressive symptoms. Gender differences were addressed in the predictive associations.
Results:Children’s emotional regulation difficulties predicted their parents’ depressive symptoms after one year, and this association was reduced by the parents’ self-compassion. No significant gender differences were found for depressive symptoms or self-compassion, and parents’ gender did not moderate any of the longitudinal associations.
Limitations: The study exhibited a small sample and a lack of cultural and socioeconomic diversity.
Conclusion: Children’s emotional regulation difficulties may predict a worsening of their parents’ depressive symptoms, but self-compassion mitigates this relationship.
A SACS deletion variant in Great Pyrenees dogs causes autosomal recessive neuronal degeneration
Authors: Ekenstedt Kari J , Minor Katie M , Shelton G Diane , Hammond James J , Miller Andrew D , Taylor Susan M , Huang Yanyun , Mickelson James R 
Published: July 2023

Abstract
ARSACS (autosomal recessive spastic ataxia of Charlevoix-Saguenay) is a human neurological disorder characterized by progressive cerebellar ataxia and peripheral neuropathy. A recently recognized disorder in Great Pyrenees dogs is similarly characterized by widespread central nervous system degeneration leading to progressive cerebellar ataxia and spasticity, combined with peripheral neuropathy. Onset of clinical signs occurred in puppies as young as four months of age, with slow progression over several years. A multi-generation pedigree suggested an autosomal recessive mode of inheritance. Histopathology revealed consistent cerebellar Purkinje cell degeneration, neuronal degeneration in brainstem nuclei, widespread spinal cord white matter degeneration, ganglion cell degeneration, inappropriately thin myelin sheaths or fully demyelinated peripheral nerve fibers, and normal or only mild patterns of denervation atrophy in skeletal muscles. Genome-wide single nucleotide polymorphism (SNP) genotype data was collected from 6 cases and 26 controls, where homozygosity mapping identified a 3.3Mb region on CFA25 in which all cases were homozygous and all controls were either heterozygous or homozygous for alternate haplotypes. This region tagged the SACS gene where variants are known to cause ARSACS. Sanger sequencing of SACS in affected dogs identified a 4bp deletion that causes a frame shift and truncates 343 amino acids from the C terminus of the encoded sacsin protein (p.Val4244AlafsTer32). Our clinical and histopathological descriptions of this canine disorder contribute significantly to the description of human ARSACS and represents the first naturally-occurring large animal model of this disorder.