bluuebunny/crossref_metadata_2025_split huggingface dataset:
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
Authors: Perike Srikanth , Gonzalez-Gonzalez Francisco J. , Abu-Taha Issam , Damen Frederick W. , Hanft Laurin M. , Lizama Ken S. , Aboonabi Anahita , Capote Andrielle E. , Aguilar-Sanchez Yuriana , Levin Benjamin , Han Zhenbo , Sridhar Arvind , Grand Jacob , Martin Jody , Akar Joseph G. , Warren Chad M. , John Solaro R. , Ong Sang-Ging , Darbar Dawood , McDonald Kerry S. , Goergen Craig J. , Wolska Beata M. , Dobrev Dobromir , Wehrens Xander H.T. , McCauley Mark D. 
Published: September 2023

BACKGROUND:
Atrial fibrillation (AF)—the most common sustained cardiac arrhythmia—increases thromboembolic stroke risk 5-fold. Although atrial hypocontractility contributes to stroke risk in AF, the molecular mechanisms reducing myofilament contractile function remain unknown. We tested the hypothesis that increased expression of PPP1R12C (protein phosphatase 1 regulatory subunit 12C)—the PP1 (protein phosphatase 1) regulatory subunit targeting MLC2a (atrial myosin light chain 2)—causes hypophosphorylation of MLC2a and results in atrial hypocontractility.

METHODS:
Right atrial appendage tissues were isolated from human patients with AF versus sinus rhythm controls. Western blots, coimmunoprecipitation, and phosphorylation studies were performed to examine how the PP1c (PP1 catalytic subunit)-PPP1R12C interaction causes MLC2a dephosphorylation. In vitro studies of pharmacological MRCK (myotonic dystrophy kinase-related Cdc42-binding kinase) inhibitor (BDP5290) in atrial HL-1 cells were performed to evaluate PP1 holoenzyme activity on MLC2a. Cardiac-specific lentiviral PPP1R12C overexpression was performed in mice to evaluate atrial remodeling with atrial cell shortening assays, echocardiography, and AF inducibility with electrophysiology studies.

RESULTS:

In human patients with AF, PPP1R12C expression was increased 2-fold versus sinus rhythm controls (
P
=2.0×10
−2
; n=12 and 12 in each group) with >40% reduction in MLC2a phosphorylation (
P
=1.4×10
−6
; n=12 and 12 in each group). PPP1R12C-PP1c binding and PPP1R12C-MLC2a binding were significantly increased in AF (
P
=2.9×10
−2
and 6.7×10
−3
, respectively; n=8 and 8 in each group). In vitro studies utilizing drug BDP5290, which inhibits T560-PPP1R12C phosphorylation, demonstrated increased PPP1R12C binding with both PP1c and MLC2a and dephosphorylation of MLC2a. Mice treated with lentiviral PPP1R12C vector demonstrated a 150% increase in left atrial size versus controls (
P
=5.0×10
−6
; n=12, 8, and 12), with reduced atrial strain and atrial ejection fraction. Pacing-induced AF in mice treated with lentiviral PPP1R12C vector was significantly higher than in controls (
P
=1.8×10
−2
and 4.1×10
−2
, respectively; n=6, 6, and 5).

CONCLUSIONS:
Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.
The impact of quality control on cortical morphometry comparisons in autism
Authors: Bedford Saashi A. , Ortiz-Rosa Alfredo , Schabdach Jenna M. , Costantino Manuela , Tullo Stephanie , Piercy Tom ,   Lifespan Brain Chart Consortium, Lai Meng-Chuan , Lombardo Michael V. , Di Martino Adriana , Devenyi Gabriel A. , Chakravarty M. Mallar , Alexander-Bloch Aaron F. , Seidlitz Jakob , Baron-Cohen Simon , Bethlehem Richard A.I. 
Published: September 2023

Abstract
Structural magnetic resonance imaging (MRI) quality is known to impact and bias neuroanatomical estimates and downstream analysis, including case-control comparisons, and a growing body of work has demonstrated the importance of careful quality control (QC) and evaluated the impact of image and image-processing quality. However, the growing size of typical neuroimaging datasets presents an additional challenge to QC, which is typically extremely time and labour intensive. One of the most important aspects of MRI quality is the accuracy of processed outputs, which have been shown to impact estimated neurodevelopmental trajectories. Here, we evaluate whether the quality of surface reconstructions by FreeSurfer (one of the most widely used MRI processing pipelines) interacts with clinical and demographic factors. We present a tool, FSQC, that enables quick and efficient yet thorough assessment of outputs of the FreeSurfer processing pipeline. We validate our method against other existing QC metrics, including the automated FreeSurfer Euler number, two other manual ratings of raw image quality, and two popular automated QC methods. We show strikingly similar spatial patterns in the relationship between each QC measure and cortical thickness; relationships for cortical volume and surface area are largely consistent across metrics, though with some notable differences. We next demonstrate that thresholding by QC score attenuates but does not eliminate the impact of quality on cortical estimates. Finally, we explore different ways of controlling for quality when examining differences between autistic individuals and neurotypical controls in the Autism Brain Imaging Data Exchange (ABIDE) dataset, demonstrating that inadequate control for quality can alter results of case-control comparisons.
Ambiguous Prayers in 1 Timothy 2:1–2: A Postcolonial Reading
Authors: Jeong Donghyun 
Published: September 2023

Abstract
This article examines the request for prayers ὑπὲρ βασιλέων in 1 Timothy 2:1–2 by focusing on three exegetical questions: (1) Who are the βασιλεῖς? (2) Are prayers for βασιλεῖς distinguishable from prayers to βασιλεῖς? And (3) to whom is this exhortation directed? The article argues that the rhetorical construction of this passage emulates and internalizes imperial ideology, but the very act of imitation has the potential to cause colonial anxiety by obscuring the colonial subjects behind this document and by disrupting any attempt at fixed interpretation.
Partisans and Participants: Democracy, New Media, and Nigerian Diaspora in New Zealand
Authors: Musa Muhammed , Antwi-Boateng Osman 
Published: September 2023

Abstract
This article argues that in the era of neo-liberal globalization there has been intensification in the movement of goods, people, and capital across national boundaries. Our ethnographic studies of Nigerian immigrants in New Zealand point to the dispersal of Africans with very active partisan roles in their homeland democratic developments. This African transnationalism, as will be seen in the case of Nigeria, is made possible and sustained by developments and transformations in the media where today new Internet-based media enable Africans abroad to play a central, partisan, and participatory role in democratic developments in the same way as those residing on the continent. The article will also argue that through the unfolding mediation new terms and acts of citizenship have been imposed on transmigrant Africans.
Cyber Security Risks in Emerging South African Smart Cities: Towards a Cyber Security Framework
Authors: Cornelius Francois Paul , Jansen van Rensburg Shandré Kim , Kader Sarika 
Published: September 2023

Abstract
Smart cities have the potential to improve the lives of citizens through the application of ICT systems that increase sustainability, service delivery, and efficiency. But, through vast connectivity and interconnected infrastructure, smart cities run the risk of falling victim to various types of cyber-attacks and information security risks. This article outlines those risks and, using a qualitative research approach, explores how a cyber security framework can inform cyber security risks in emerging South African smart cities. As such, a South African, smart city, cyber security risk framework is proposed based on the findings of interviews conducted with 17 Subject Matter Experts (SMEs). The framework is aimed at assisting smart city developers during the design, selection, and implementation of the cyber security operations within the South African context and serves as an example to other developing countries.
Less than Confirming, and Doing More than That: Comparing Responses to Requests for Confirmation in German and Yurakaré
Authors: Gipper Sonja , Groß Alexandra 
Published: September 2023

Abstract
In this paper, we compare practices of formulating responses to requests for confirmation oriented toward confirmation but doing less or more than that in German and Yurakaré (isolate, Bolivia). The German particle joa is identified as a versatile resource for navigating the functional spectrum of such responses, being deployed for less than confirming in terms of epistemic or propositional downgrading, and for more than confirming in terms of addressing terms of questions or a confirmable’s valence. When exercising these specific tasks, speakers of Yurakaré, in contrast, rely mostly on repetitional strategies, while a highly specialised particle constitutes an ‘escape strategy’ when a repeat would convey unwanted implications. We propose that doing less and more than confirming is contingent on a more fundamental distinction: a preference for particles (German) vs. repeats (Yurakaré) in the realm of plain confirmation, which carries over to responses doing less and more than confirming.
A Person-Centered Approach to Emotional Security: Latent Profile Analysis of the Dark Triad and Psychological Symptoms
Authors: Kaya Alican , Mukba Gamze , Özok Halil İbrahim 
Published: September 2023

Few studies have examined emotional security utilizing a person-centered approach. Therefore, in the present study, we conceptualized a multidimensional construct that includes psychological symptoms (i.e., depression, anxiety, and stress) and the dark triad traits (i.e., Machiavellianism, narcissism, and psychopathy). Applying latent profile analysis (LPA) allows the exploration of the interaction of emotional security with the dark triad traits and psychological symptoms in the sample at the level of sub-classes. Depression, stress, anxiety, Machiavellianism, narcissism, and psychopathy were determined as profile indicators. Moreover, satisfaction with life and the psychological well-being of the sub-classes were predicted. Data were gathered from 558 participants (418 females, %74.9) with an average age of 22.44 years). LPA indicated four distinct profiles: ‘High emotional security and low psychological symptoms, and dark triad traits’ (22%), ‘Low emotional security and high psychological symptoms, dark triad traits’ (5%), ‘Low emotional security and moderate dark triad traits’ (28%), ‘Moderate emotional security, psychological symptoms, and dark triad traits’ (45%). Mixture modeling approach-based research provides a complementary view of the previous psychopathology literature. The findings could help practitioners target at-risk university students with low emotional security, low psychological well-being, and low life satisfaction and design programs to aid them in alleviating the psychological symptoms and the dark triad traits.
A prospective study comparing the quality of coronary computed tomography angiography images from photon counting and energy integrating detector systems
Authors: Skoog Susann , Sandborg Michael , Henriksson Lilian , Sandstedt Mårten , Gustafsson Håkan , Persson Anders 
Published: September 2023

Background As guidelines endorse the use of computed tomography (CT) for examining coronary artery disease (CAD), it is important to compare the advantages and disadvantages of the novel photon counting detector CT (PCD-CT) technology with the established energy integrating detector CT (EID-CT). Purpose To compare the image quality of coronary computed tomography angiography (CCTA) and the Agatston scores (AS) derived from EID-CT and PCD-CT. Material and Methods In this prospective observational study, 28 patients underwent clinical calcium score and CCTA scans on an EID-CT and a PCD-CT scanner. CCTA images were qualitatively analyzed by five observers using visual grading characteristics. The correlation and agreement of the AS were assessed using Spearman's rank correlation and Bland–Altman plots. Results This qualitative analyses demonstrated a high fraction of “good” or “excellent” ratings for the image criteria in both CT systems. The sharpness of the distal lumen and image quality regarding motion artifacts were rated significantly higher for EID-CT ( P < 0.05). However, the sharpness of coronary calcification was rated significantly higher for PCD-CT ( P < 0.05). Spearman's rank correlation and Bland–Altman plots showed good correlation ( P = 0.95) and agreement regarding the AS between EID-CT and PCD-CT. Conclusion Both CT systems exhibited high CCTA image quality. The sharpness of calcifications was rated significantly higher for PCD-CT. A good correlation was observed between the AS derived from the two systems.
Machine learning models based on multi-parameter MRI radiomics for prediction of molecular glioblastoma: a new study based on the 2021 World Health Organization classification
Authors: Kong Xin , Mao Yu , Luo Yuqi , Xi Fengjun , Li Yan , Ma Jun 
Published: September 2023

Background The 2021 World Health Organization (WHO) classification considers a histological low grade glioma with specific molecular characteristics as molecular glioblastoma (mGBM). Accurate identification of mGBM will aid in risk stratification of glioma patients. Purpose To explore the value of machine learning models based on magnetic resonance imaging (MRI) radiomics features in predicting mGBM. Material and Methods In total, 166 patients histologically diagnosed as low-grade diffuse glioma (WHO II and III) were included in the study. Fifty-three cases were reclassified as mGBM based on molecular status. Four dimensionality reduction methods including distance correlation (DC), gradient boosted decision tree (GBDT), least absolute shrinkage and selection operator (LASSO) and minimal redundancy maximal relevance (MRMR) were used to select the optimal signatures. Six machine learning algorithms including support vector machine (SVM), linear discriminant analysis (LDA), neural network (NN), logistic regression (LR), K-nearest neighbour (KNN) and decision tree (DT) were used to develop the classifiers. The relative SD was used to evaluate the stability of the models, and the area under the curve values in the independent test group were used to evaluate their performances. Results NN_DC was determined as the optimal classifier due to the highest area under the curve of 0.891 in the test group. The classification accuracy, sensitivity, specificity, positive predictive value and negative predictive value of NN_DC were 0.915, 0.842, 0.950, 0.889 and 0.927, respectively. Conclusion Machine learning models can predict mGBM non-invasively, which may help to develop personalized treatment strategies for neurosurgeons and provide an effective tool for accurate stratification in clinical trials.
Damage behavior and dynamic response of nano-silica reinforced aluminum 2024-T3/GFRP composite laminate subjected to high-velocity impact
Authors: Vijayan Muniyan , Velappan Selladurai , Ayyavoo Karthikeyan 
Published: September 2023

This study focuses on analyzing the damages and ballistic limit for the fiber metal laminate (FML) and nano-silica reinforced FML. FML materials are hybrid sandwich composite materials used in lightweight structural applications. FML is constructed as a sandwich structure by bonding an aluminum alloy and a glass fiber reinforced composite. To enhance the impact strength of the FML composite, it was reinforced with nano-silica particles within the epoxy resin at various concentrations ranging from 1 wt% to 7 wt%. The laminates are then subjected to high-velocity impact tests using a single-stage gas gun setup, to assess the failure modes of the FML in an aluminum sheet and nanocomposite layers. The influence of nano-silica on natural frequency and damping factor is also examined by using a shock sensor and DAQ (Data Acquisition system). Results indicate that the FML laminate containing 5 wt% nano-silica demonstrates superior impact resistance compared to other filler percentages, as demonstrated by the ballistic limit and damage assessment. The ballistic limit for the pure FML laminate without nano-silica is 98 m/s, whereas the FML laminate containing 5 wt% nano-silica exhibits a peak value of 112 m/s, presenting a notable 14.3% increase in ballistic limit compared to the pure FML. Additionally, the dynamic response analysis reveals changes in the natural frequency values of the laminates before and after impact, indicating permanent damage to the laminate structure.
A numerical investigation of the effect of vaned diffuser water cooling on the internal flow field of a centrifugal compressor
Authors: Wang Yu , Chen Hua , Li Chao , Ma Chao 
Published: September 2023

Due to their high pressure rises, the gas temperature of high-speed centrifugal compressors can be very high to the detriment of compressor aerodynamic performance. A water-cooled vaned diffuser technique is proposed to alleviate this problem. Compressor housing integrated water-cooling passages are employed to introduce cooling water to the vanes through holes near the vane centre. The technique was applied to a 180 mm turbocharger compressor running at the tip speed of 452 m/s, and numerical studies with conjugate heat transfer and fluid-structure thermal interaction were carried out to find the effects of the cooling to compressor performance and the mechanical stress of diffuser vanes. The results show that compressor efficiency is improved by the cooling, and the improvement increases as compressor mass flow reduces. At modest pressure ratios around 3.3, the maximum improvement of 1.09 percentage points is achieved using 30°C inlet water temperature. The cooling is found to significantly reduce the air temperature near diffuser passage solid walls, thus lead to more uniform air temperatures at compressor exit. The reduction of 1.33°C and 2.21°C in the diffuser outlet temperature have been found at 1.68 kg/s air mass flow with 70°C and 30°C water inlet temperature respectively. Moreover, the thermal stress in diffuser vanes is shown to be lower with the cooling.
Professional values and nursing care quality: A descriptive study
Authors: Brickner Shanon , Fick Kerry , Panice Jessica , Bulthuis Katherine , Mitchell Rita , Lancaster Rachelle 
Published: September 2023

Background Professional values are important in promoting healthy work environments, patient satisfaction, and quality of care. Magnet® hospitals are recognized for excellence in nursing care and as such, understanding the relationship between nurses' values and Magnet status is essential as healthcare organizations seek to improve patient outcomes. Research question/aim/objectives The research question is: are there differences in individual values, professional values, and nursing care quality for nurses and nurse managers practicing in Magnet, Magnet journey, and non-Magnet direct patient care settings? Research Design This descriptive cross-sectional study is guided and informed by the conceptual framework of the Professional Values Model including individual values, professional values, and nursing care quality. Participants and research context Convenience sampling of registered nurses and nurse managers, responsible for direct patient care, was utilized in a non-profit healthcare system in the Midwest region of the United States. Ethical Considerations Institutional review board approval was obtained. Participants were informed about the right to self-determine participation and assurance of anonymity. Findings 827 (n = 827) nurses and nurse managers responded to the survey. Significant differences were identified in individual values sub-scale: self-enhancement ( p = 0.38), professional values ( p = 0.037), practice environment: participation in hospital affairs ( p = 0.00), foundations for quality care ( p = 0.016), and resources adequacy ( p = 0.012) and in nurse sensitive HCAHPS questions: nurses explained things understandably ( p = 0.00), got help as soon as wanted ( p = 0.00), and treated with courtesy and respect ( p = 0.00). Discussion/Conclusions Findings indicate that fostering individual and professional values may impact nursing practice, regardless of Magnet designation. Promoting professional values may contribute to improved work environments, enhancing patient satisfaction. Study results offer valuable insights for organizations striving to enhance nursing values, impacting quality of care provided to patients. MeSH Terms Cross-Sectional Studies, Respect, Ethics Committees, Patient Satisfaction, Nurse Administrators, and Personal Satisfaction.
Unveiling the burden of compassion fatigue in nurses
Authors: Taşdemir Halil İbrahim , Aydın Ruveyde , Dursun Ergezen Fatma , Taşdemir Deniz , Ergezen Yahya 
Published: September 2023

Background The COVID-19 pandemic has placed an unprecedented burden on nurses who have been at the forefront of patient care. The continuous exposure to suffering, death, and overwhelming demands has the potential to lead to compassion fatigue, a state of emotional, physical, and cognitive exhaustion. Research aim The study aimed to explore and understand the phenomenon of compassion fatigue in nurses as the effect of the COVID-19 pandemic. Research design A constructivist grounded theory design was used. Participants and research context The research data were collected from 20 nurses who had been employed in pandemic clinics in Turkey for a minimum of 6 months. Data were collected using a two-step approach: purposeful sample selection followed by theoretical sample selection. Individual interviews were conducted via an online platform with participants who consented to participate in the study from January 16th to April 28th, 2022. The collected data underwent initial, focused, and theoretical coding for analysis. The research findings were reported following the Consolidated Criteria for Reporting Qualitative Research guidelines. Ethical considerations Ethical approval for the study was received from Non-Interventional Clinical Research Ethics Committee. The study was conducted following the Declaration of Helsinki. Findings The study identified a core category, namely the desire to provide the best care, which was accompanied by five main categories: causes, symptoms, consequences, coping methods, and the benefits of coping methods. Conclusion During the pandemic process, nurses have experienced compassion fatigue due to various factors and have seen its symptoms. Nurses have developed various coping mechanisms individually. However, they have not indicated any institutional-level support. It has become necessary to plan nurse-centered comprehensive interventions that will reduce compassion fatigue.