bluuebunny/crossref_metadata_2025_split huggingface dataset:
A performance study of R717 and R22 as the working fluid for OTEC plant
Authors: Chan W L , Chiong M S 
Published: March 2023

Abstract
The purpose of this paper is to compare the thermal efficiency of an ocean thermal energy conversion (OTEC) cycle using R717 and R22 working fluids. An OTEC system typically operates at the temperature difference between the average warm surface seawater of 30 °C and the cold deep seawater of 8 °C. The temperature difference will then power a turbine to produce electricity. R22 and R717 are two potential working fluids to be used in the OTEC cycle to absorb heat due to their saturation temperature. However, R22 is associated with higher global warming potential and the global warming potential (GWP) of 1,760, compared to R717 with zero GWP. The study shows that the thermal efficiency of R22 is 0.211% higher than R717. Moreover, the thermal power required by the water circuit to cool/heat the OTEC circuit for R717 is 13% higher than R22. However, the required working fluid flow rate of the R717 system is 81.5% lower than R22, making the former significantly smaller in size.
The application of analytic hierarchy process for innovative solution: A review
Authors: Samanaseh V , Noor Z Z , Mazlan M A 
Published: March 2023

Abstract
The Analytic Hierarchy Process (AHP) serves as an all-inclusive and logical approach to evaluate complex decisions making. This paper discusses a review on the methods of AHP in various power plant and production plant for multiple factors as well as indicates potential gaps from the researchers’ perspectives. Many analyses have identified various AHP applications to solving problems that necessitate both qualitative and quantitative elements. Generally, the applications of AHP cover large scale (complicated and real) and industrial oriented problems. A larger part of these applications or AHP case studies are arranged and a couple of paper focused on adding to AHP displaying prior to applying practical problems. As evidenced in this review, AHP has been applied in innovative solutions in industries such as biological treatment process, hydropower plant, electricity generation, and plastic waste management. Hence, this review provides a comprehensive list of the various applications of AHP in activities and fosters a system for highlighting the areas that that future researchers should focus on to assure a more thorough evaluation of the gaps.
Application of GeoWEPP model in ditch crossing soil landfill engineering
Authors: Yang Luying 
Published: March 2023

Abstract
Loess Plateau provides a broad growing environment for crops. However, due to the loose soil, soil erosion is serious. Gully Consolidation and Highland Protection is the key work in the construction of ecological civilization in Loess Plateau. Using the method of simulating the Gully Consolidation and Highland Protection, the terrain conditions are changed, and the hydrological model is used to simulate the change of erosion before and after ditch head landfill. In this paper, Yangjiagou, was chosen as the research area. The spatial analysis function of ArcGIS was used to process DEM, and GeoWEPP model was used to simulate soil erosion, the variation of runoff and sediment yield in gully head landfill before and after landfill was analyzed. Results show that gully head landfill has effective on soil erosion control and provides an effective verification method for the feasibility of soil erosion control scheme in the Loess Plateau.
Assessment of safety control measures for centralized Chlorine gas system
Authors: Idris M A , Chelliapan S 
Published: March 2023

Abstract
As a glove manufacturing plant, the chemical is one of the most highly used materials. Some chemicals impact human health, environmental aspects, and physical hazards such as highly flammable gas. Chlorine gas is one of them. Besides the accidental release of chlorine gas incidents, ill-health issues are another aspect that should be taken care of. This study aims to determine the current chlorine concentration at a centralized chlorine gas manifold system in a rubber glove manufacturing plant and evaluate the existing safety control measures. A concept of safety by design, inherently safety, and the fail-safe system was considered during the study. The results show that the chlorine concentration level during drum replacement by the crew is at an average of 1.154 ppm and the standard deviation at 0.3478. The highest concentration was at 1.8 ppm. The wet scrubber assessment was done using the Industrial Ventilation and visual assessments and measurements within the system, including capture velocity, face velocity, and duct velocity or transport velocity. Other assessed parameters are total pressure, static pressure, and velocity pressure. The assessment found that the duct performance for all parameters complies with a minimum requirement of the American Conference of Governmental Industrial Hygienists (ACGIH) guidelines.
Impact of pandemic COVID-19 on solid waste compositional trends in pasar awam maharani Muar
Authors: Isa N , Tamunaidu P , Ali A H M , Goto M , Yen L P , Balasundram V , Huzir N M , Rosly M B , Hussin M H , Amin A N R 
Published: March 2023

Abstract
The world was astounded by the emergence of the deadly virus COVID-19 at the end of 2019. In March 2020, Malaysia’s first Movement Control Order (MCO) was initiated to stop the spread of the virus that ended in June 2021. Hence, this paper was initiated to study the impact of the pandemic and MCO on the generation of waste in Pasar Awam Maharani Muar (PAMM). The waste generation rate and the trend of waste accumulation according to different categories were recognised. The PAMM operates 8 hours daily, and the area strictly observes Standard Operating Procedures (SOP) established by the government. The compositional study was performed two times for 14 days in a month. The solid waste was segregated, and the weight were measured accordingly. The average total solid waste generated from 30 stalls was around 1.5 tonnes daily. It was further established that 38.5% of the waste comprised of chicken and fish waste, 36.3% formed inorganic waste, and 25.2% constituted vegetable and fruit waste. Several limitations were acknowledged in this research which was the short operational time, unpredictable weather, public holidays, and the closure of PAMM on Sundays. Observations also showed that some stall owners were highly mindful of the solid waste segregation and some of the organic wastes were reused as ruminant feed and some for composting.
Research on the energy consumption mechanism and characteristics of the gallium indium tin liquid metal arcing process
Authors: MA Yaguang , GAO Guoqiang , XIANG Yu , PENG Wei , DONG Keliang , QIAN Pengyu , YOU Bingyan , YANG Zefeng , WEI Wenfu , WU Guangning 
Published: March 2023

Abstract
For high-voltage direct current (HVDC) power grid transmission with higher voltages, the energy-consuming branch of the DC circuit breaker is required to dissipate huge energies of more than megajoules in a short time in the case of a fault and short circuit. The requirements for huge volume and weight are difficult to meet with energy-consuming equipment based on ZnO. In this paper, a new energy consumption method is proposed based on gallium indium tin (GaInSn) liquid metal in the arcing process, and a test platform with adjustable short-circuit current is built. The mechanism triggering GaInSn liquid metal arcing energy consumption is studied. It is found that short-circuit current and channel aperture are the key parameters affecting the energy consumption of liquid metal arcing. The characteristics of GaInSn liquid metal energy consumption are investigated, and four stages of liquid metal energy consumption are found: oscillatory shrinkage, arc breakdown, arc burning phase change and arc extinction. The influence of short-circuit current and channel aperture on the energy consumption characteristics of GaInSn liquid metal is investigated. To further explore the physical mechanism of the above phenomena, a magneto-hydrodynamic model of energy consumption in the GaInSn liquid metal arcing process is established. The influence of short-circuit current and channel aperture on the temperature distribution of the liquid metal arc is analyzed. The mechanism of the effect of short-circuit current and channel aperture on peak arc temperature and the temperature diffusion rate is clarified. The research results provide theoretical support for this new liquid metal energy consumption mode DC circuit breaker.
Expanding the Immunophenotypic Spectrum of Neoplastic and Reactive Plasmacytoid Dendritic Cells
Authors: Wu Sarah J , Sadigh Sam , Lane Andrew A , Pinkus Geraldine S 
Published: March 2023

Abstract

Objectives
Targeted therapies for blastic plasmacytoid dendritic cell neoplasm (BPDCN) have presented a diagnostic dilemma for differentiating residual BPDCN from reactive plasmacytoid dendritic cells (pDCs) because these conditions have a similar immunoprofile, necessitating discovery of additional diagnostic markers.

Methods
Fifty cases of BPDCN involving bone marrow (26/50) and skin (24/50) as well as other hematologic malignancies (67) and nonneoplastic samples (37) were included. Slides were stained using a double-staining protocol for the following immunohistochemical marker combinations: TCF4/CD123, TCF4/CD56, SOX4/CD123, and IRF8/CD123.

Results
The nuclear marker SOX4 is expressed in neoplastic pDCs; in our cohort, SOX4/CD123 showed 100% sensitivity and 98% specificity in distinguishing BPDCN from reactive pDCs and other neoplasms. TCF4/CD56 had a 96% sensitivity and 100% specificity for BPDCN. IRF8 is a nonspecific marker that is positive in BPDCN and pDCs as well as other myeloid malignancies.

Conclusions
The novel immunohistochemical combination SOX4/CD123 distinguishes BPDCN, including CD56-negative BPDCN, from both reactive pDCs and other neoplasms. Because of their high diagnostic sensitivity and specificity, the double-staining marker combinations TCF4/CD123, TCF4/CD56, and SOX4/CD123 can be used to confirm lineage in BPDCN cases and detect minimal/measurable residual disease in tissue specimens.
Mitochondrial, morphological and environmental data partially support current subspecies designation inAmazilia yucatanensishummingbirds
Authors: Vásquez-Aguilar Antonio Acini , MacSwiney G M Cristina , Rodríguez-Gómez Flor , Ornelas Juan Francisco 
Published: March 2023

AbstractHistorical geological events and Pleistocene climatic fluctuations have played important roles in shaping distribution and population differentiation across taxa. The buff-bellied hummingbird (Amazilia yucatanensis) is widely distributed along the Gulf of Mexico slope and the Yucatan Peninsula. Here, we obtained measurements and sequenced two mitochondrial DNA fragments from currently recognized subspecies: Amazilia yucatanensis yucatanensis (YUC), Amazilia yucatanensis cerviniventris (CER) and Amazilia yucatanensis chalconota (CHA). Additionally, we tested for their genetic and morphological differentiation, demographic expansion, palaeoclimatic distribution and niche overlap. Our results reveal genetic differentiation between two groups of populations: (1) from the Yucatan Peninsula to Veracruz (YUC+CER); and (2) from Veracruz to Tamaulipas (CHA). Neutrality tests and Bayesian skyline plots suggest past demographic expansion without changes in the effective population size over time. The potential distribution was fragmented at the Trans-Mexican Volcanic Belt and expanded northwards during the Last Glacial Maximum and Mid-Holocene to current conditions. Niche overlap was higher between YUC and CER. The environmental space occupied by subspecies was more similar to each other than expected by chance but significantly non-equivalent. Our results provide new insight on the distribution of this widespread hummingbird species and suggest that fragmentation during glaciations and differences in habitat have played a role in the recent diversification.
Global epidemiology and disparities in atopic dermatitis
Authors: Mosam Anisa , Todd Gail 
Published: March 2023

Abstract
Atopic dermatitis (AD) affects children and adults worldwide. Advancements have been made towards unravelling the pathogenesis of AD, identifying various triggers, linking the environment and psychosocial factors with disease and the development of therapeutic targets to improve disease control. This article describes the global epidemiology of AD and the disparities that exist in various populations and regions across the globe. AD prevalence and burden varies widely both within and between countries inhabited by the same ethnic groups, which suggests strong environmental influences in disease expression, with socioeconomic status and affluence considered to be the main driving factors. Inequities in access to healthcare, and the quality of healthcare provided, among racial and ethnic minority groups are well documented. Disparities in access to various topical and systemic therapies are affected by barriers to registration and approval, cost, manufacturing, supply and approval by medical insurance companies and governments. Identifying the factors driving the inequities in access to healthcare is central to achieving better patient care.
Polygenic risk of type 2 diabetes is associated with incident vascular dementia: a prospective cohort study
Authors: Dybjer Elin , Kumar Atul , Nägga Katarina , Engström Gunnar , Mattsson-Carlgren Niklas , Nilsson Peter M , Melander Olle , Hansson Oskar 
Published: March 2023

Abstract
Type 2 diabetes and dementia are associated, but it is unclear whether the two diseases have common genetic risk markers that could partly explain their association. It is also unclear whether the association between the two diseases is of a causal nature. Furthermore, few studies on diabetes and dementia have validated dementia end-points with high diagnostic precision. We tested associations between polygenic risk scores for type 2 diabetes, fasting glucose, fasting insulin and haemoglobin A1c as exposure variables and dementia as outcome variables in 29 139 adults (mean age 55) followed for 20–23 years. Dementia diagnoses were validated by physicians through data from medical records, neuroimaging and biomarkers in cerebrospinal fluid. The dementia end-points included all-cause dementia, mixed dementia, Alzheimer’s disease and vascular dementia. We also tested causal associations between type 2 diabetes and dementia through two-sample Mendelian randomization analyses. Seven different polygenic risk scores including single-nucleotide polymorphisms with different significance thresholds for type 2 diabetes were tested. A polygenic risk score including 4891 single-nucleotide polymorphisms with a P-value of &lt;5e-04 showed the strongest association with different outcomes, including all-cause dementia (hazard ratio 1.11; Bonferroni corrected P = 3.6e-03), mixed dementia (hazard ratio 1.18; Bonferroni corrected P = 3.3e-04) and vascular dementia cases (hazard ratio 1.28; Bonferroni corrected P = 9.6e-05). The associations were stronger for non-carriers of the Alzheimer’s disease risk gene APOE ε4. There was, however, no significant association between polygenic risk scores for type 2 diabetes and Alzheimer’s disease. Furthermore, two-sample Mendelian randomization analyses could not confirm a causal link between genetic risk markers of type 2 diabetes and dementia outcomes. In conclusion, polygenic risk of type 2 diabetes is associated with an increased risk of dementia, in particular vascular dementia. The findings imply that certain people with type 2 diabetes may, due to their genetic background, be more prone to develop diabetes-associated dementia. This knowledge could in the future lead to targeted preventive strategies in clinical practice.
In-Depth Excavation and Screening of Triterpene Saponins From the Rhizome of Panax japonicus Using High Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry
Authors: Ling Yun , Ouyang Yukun , Xue Yiran , Yu Jingmou , Liu Wenbo 
Published: March 2023

Abstract
The rhizome of Panax japonicus (RPJ) has been used for thousands of years in west China. Triterpene saponins (TSs) were considered to be the main pharmacologically bioactive ingredients in RPJ. However, it is difficult and time-consuming to profile and identify them according to the traditional phytochemical methods. High-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) was used for chemical identification of TSs from the extract of RPJ in negative ion mode. Their chemical structures were tentatively elucidated based on exact formulas, fragmentation patterns and literature data. In all, 42 TSs were discovered and tentatively characterized in RPJ, of which 12 TSs were identified as potential new compounds according to their molecular mass, fragmentation pattern and chromatographic behavior. The results demonstrated that the developed HPLC-ESI-QTOF-MS/MS method was conducive to the discovery of the active ingredients of RPJ and the establishment of quality standards.
Real-World Application of Oral Therapy for Infective Endocarditis: A Multicenter, Retrospective, Cohort Study
Authors: Freling Sarah , Wald-Dickler Noah , Banerjee Josh , Canamar Catherine P , Tangpraphaphorn Soodtida , Bruce Dara , Davar Kusha , Dominguez Fernando , Norwitz Daniel , Krishnamurthi Ganesh , Fung Lilian , Guanzon Ashley , Minejima Emi , Spellberg Michael , Spellberg Catherine , Baden Rachel , Holtom Paul , Spellberg Brad 
Published: March 2023

Abstract

Background
We sought to compare the outcomes of patients treated with intravenous (IV)-only vs oral transitional antimicrobial therapy for infective endocarditis (IE) after implementing a new expected practice within the Los Angeles County Department of Health Services (LAC DHS).

Methods
We conducted a multicentered, retrospective cohort study of adults with definite or possible IE treated with IV-only vs oral therapy at the 3 acute care public hospitals in the LAC DHS system between December 2018 and June 2022. The primary outcome was clinical success at 90 days, defined as being alive and without recurrence of bacteremia or treatment-emergent infectious complications.

Results
We identified 257 patients with IE treated with IV-only (n = 211) or oral transitional (n = 46) therapy who met study inclusion criteria. Study arms were similar for many demographics; however, the IV cohort was older, had more aortic valve involvement, were hemodialysis patients, and had central venous catheters present. In contrast, the oral cohort had a higher percentage of IE caused by methicillin-resistant Staphylococcus aureus. There was no significant difference between the groups in clinical success at 90 days or last follow-up. There was no difference in recurrence of bacteremia or readmission rates. However, patients treated with oral therapy had significantly fewer adverse events. Multivariable regression adjustments did not find significant associations between any selected variables and clinical success across treatment groups.

Conclusions
These results demonstrate similar outcomes of real-world use of oral vs IV-only therapy for IE, in accord with prior randomized, controlled trials and meta-analyses.
Case report: a breathtaking complication after ablation—using multi-modal imaging for timely diagnosis of acquired pulmonary vein stenosis and its implication for effective management
Authors: Tseng Joyee , Younus Masood , Singh Gagan D , Lee Jin Sol Gene 
Published: March 2023

AbstractBackgroundAcquired pulmonary vein stenosis (PVS) is a rare, but serious, complication that can develop after treatment with ablations for atrial fibrillation. Prompt diagnosis is difficult because it can often present similarly to other pulmonary disease processes.Case summaryWe describe a 62-year-old female with history of persistent symptomatic atrial fibrillation that resolved status post two radio-frequency ablations who presents with ongoing dyspnoea, productive cough, pleuritic chest pain, and haemoptysis over multiple admissions. She was misdiagnosed with recurrent pneumonias and pulmonary embolism that failed to improve her symptoms. She was referred to our centre for further evaluation finding severe stenosis in the left superior pulmonary vein with complete obliteration of the left inferior pulmonary vein on computed tomography scan. Multi-modal imaging including an echocardiogram and pulmonary angiogram was used to confirm the diagnosis. Percutaneous intervention with transvenous pulmonary vein venoplasty with pulmonary vein stenting of the left upper pulmonary vein was offered which resolved the patient’s aforementioned symptoms.ConclusionPrompt diagnosis of acquired pulmonary vein stenosis is critical to plan for effective management. Our case highlights the need to consider PVS with a high index of clinical suspicion when a patient’s medical history is significant for a prior history of ablation. We also review the use of multi-modal imaging to diagnose and plan for effective management with percutaneous intervention.
Speckle tracking echocardiography-derived parameters as new prognostic markers in hypertrophic cardiomyopathies
Authors: Faro Denise Cristiana , Losi Valentina , Rodolico Margherita Stefania , Licciardi Salvatore , Monte Ines Paola 
Published: March 2023

AbstractAimsHypertrophic cardiomyopathies (HCM) are caused in 30–60% of cases by mutations in cardiac sarcomere genes but can also be an expression of cardiac involvement in multi-systemic metabolic diseases, such as Anderson–Fabry disease (AFD). HCM entails a risk of sudden cardiac death (SCD) of 0.9%/year and is the most common cause of SCD in young adults. Recent studies suggested mechanical dispersion (MD) by speckle tracking echocardiography (STE) as an additional arrhythmic risk marker. The aim of the study was to evaluate left ventricle global longitudinal strain (LV-GLS) and MD, in patients with HCM or AFD cardiomyopathy, and the association with ventricular arrhythmias (V-AR).Methods and resultsWe evaluated 40 patients with HCM, 57 with AFD (12 with LV hypertrophy and 45 without), and 40 healthy subjects, between January 2014 and June 2022. We performed a comprehensive echocardiographic study and analysed systolic and diastolic functions, LV-GLS, and MD. We also analysed V-AR, including ventricular fibrillation and sustained/non-sustained ventricular tachycardia, by Holter electrocardiogram (Holter-EKG), in a subset of hypertrophic patients. Data were analysed by unpaired Student t-test or chi-square/Fisher’s exact test as appropriate and binary logistic regression (SPSS Statistics ver.26). LV-GLS was significantly lower in the V-AR group compared with patients without V-AR (median −10.2% vs. −14%, P = 0.038); MD was significantly higher in the V-AR group (85.5 ms vs. 61.1 ms, P = 0.004). V-AR were found significantly associated with MD (OR, 1.030; 95% CI, 1.003–1.058; P = 0.03).ConclusionsMD is a useful additional index in the evaluation of patients with HCM and may be a promising prognostic predictor of increased arrhythmic risk.