bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beads and Stamps in the Middle Orinoco: Archaeological Evidence for Interaction and Exchange in the Atures Rapids from AD 1000 to 1480
Authors: Lozada-Mendieta Natalia , Riris Philip , Oliver José R. 
Published: December 2022

AbstractThe area of the Atures Rapids in the Middle Orinoco River (Venezuela), where multiple Indigenous communities gathered to trade goods, has been identified as a prominent center of commerce since early colonial times. However, the exchange activities taking place there between local and nonlocal actors before European colonization are poorly understood, based only on the ethnohistoric record. This article presents an archaeometric analysis of stone beads and ceramic roller stamps, items previously associated with trade practices, from two recently excavated sites in the region, Picure (AD 1030–1480) and Rabo de Cochino (AD 1000–1440); it assesses their provenance, production, and value. We propose that Picure was a site of a bead-manufacturing workshop and a place where roller stamps were exchanged. The stamps were acquired and produced by different potting groups. Analysis of the chaîne opératoire and production techniques shows processes of adaptation and emulation associated with the multiple, multiethnic communities during the period from AD 1000 to 1480. Both beads and stamps are linked to identity regalia that were likely used as part of ceremonies taking place in the area of the Rapids, as indicated by the numerous and monumental petroglyphs found on the islands.
NEWLY DISCOVERED ILLUSTRATED TEXTS OF ARATUS AND ERATOSTHENES WITHIN CODEX CLIMACI RESCRIPTUS
Authors: Williams Peter J. , James Patrick , Klair Jamie , Malik Peter , Zaman Sarah 
Published: December 2022

AbstractThis article presents texts recovered by post-processing of multispectral images from the fifth- or sixth-century underwriting of the palimpsest Codex Climaci Rescriptus. Texts identified include the Anonymous II Proemium to Aratus’ Phaenomena, parts of Eratosthenes’ Catasterisms, Aratus’ Phaenomena lines 71–4 and 282–99 and previously unknown text, including some of the earliest astronomical measurements to survive in any Greek manuscript. Codex Climaci Rescriptus also contains at least three astronomical drawings. These appear to form part of an illustrated manuscript, with considerable textual value not merely on the basis of its age but also of its readings. The manuscript undertexts show significant overlap with the Φ Edition, postulated as ancestor of the various Latin Aratea.
A review of natural hydrofractures in rocks
Authors: Bons Paul D , Cao Dongsheng , de Riese Tamara , González-Esvertit Eloi , Koehn Daniel , Naaman Isaac , Sachau Till , Tian He , Gomez-Rivas Enrique 
Published: December 2022

AbstractHydrofractures, or hydraulic fractures, are fractures where a significantly elevated fluid pressure played a role in their formation. Natural hydrofractures are abundant in rocks and are often preserved as magmatic dykes or sills, and mineral-filled fractures or mineral veins. However, we focus on the formation and evolution of non-igneous hydrofractures. Here we review the basic theory of the role of fluid pressure in rock failure, showing that both Terzaghi’s and Biot’s theories can be reconciled if the appropriate boundary conditions are considered. We next discuss the propagation of hydrofractures after initial failure, where networks of hydrofractures may form or hydrofractures may ascend through the crust as mobile hydrofractures. As fractures can form as a result of both tectonic stresses and an elevated fluid pressure, we address the question of how to ascertain whether a fracture is a hydrofracture. We argue that extensional or dilational fractures that formed belowc.2–3 km depth are, under normal circumstances, hydrofractures, but at shallower depth they may, but must not be hydrofractures. Since veins and breccias are often the products of hydrofractures that are left in the geological record, we discuss these and critically assess which vein structures can, and which do not necessarily, indicate hydrofracturing. Hydrofracturing can suddenly and locally change the permeability in a rock by providing new fluid pathways. This can lead to highly dynamic self-organization of crustal-scale fluid flow.
Neural-learning-enhanced Cartesian Admittance control of robot with moving RCM constraints
Authors: Su Hang , Schmirander Yunus , Valderrama-Hincapié Sarah Elena , Qi Wen , Ovur Salih Ertug , Sandoval Juan 
Published: December 2022

AbstractIn this manuscript, a scheme for neural-learning-enhanced Cartesian Admittance control is presented for a robotic manipulator to deal with dynamic environments with moving remote center of motion (RCM) constraints. Although some research has been implemented to address fixed constrained motion, the dynamic moving movement constraint is still challenging. Indeed, the moving active RCM constraints generate uncertain disturbance on the robot tool shaft with unknown dynamics. The neural-learning-enhanced decoupled controller with disturbance optimisation is employed and implemented to maintain the performance under the kinematic uncertain and dynamic uncertain generated. In addition, the admittance Cartesian control method is introduced to control the robot, providing compliant behaviour to an external force in its operational space. In this proposed framework, a neural-learning-enhanced disturbance observer is investigated to calculate the external factor operating on the end effector premised on generalised momentum in order to ensure accuracy. Finally, the experiments are implemented using a redundant robot to validate the efficacy of the suggested approach with moving RCM constraints.
The effect of clinical and haemodynamic variables on post-operative length of stay immediately upon admission after biventricular repair with Yasui operation following an earlier Norwood operation
Authors: Loomba Rohit S. , Dyamenahalli Umesh , Savorgnan Fabio , Acosta Sebastian , Elhoff Justin J. , Farias Juan S. , Villarreal Enrique , Flores Saul 
Published: December 2022

AbstractBackground:There are a variety of approaches to biventricular repair in neonates and infants with adequately sized ventricles and left-sided obstruction in the presence of a ventricular septal defect. Those who undergo this in a staged manner initially undergo a Norwood procedure followed by a ventricular septal defect closure such that the neo-aorta is entirely committed to the left ventricle and placement of a right ventricular to pulmonary artery conduit (Yasui operation). This study aimed to determine clinical and haemodynamic factors upon paediatric cardiac ICU admission immediately after the two-stage Yasui operation that was associated with post-operative length of stay.Methods:This was a retrospective review of patients who underwent the Yasui procedure after the initial Norwood operation between 1 January 2011 and 31 December 2020. Patients with complete data on admission were identified and analysed using Bayesian regression analysis.Results:A total of 15 patients were included. The median age was 9.0 months and post-operative length of stay was 6days. Bayesian regression analysis demonstrated that age, weight, heart rate, mean arterial blood pressure, central venous pressure, pulse oximetry, cerebral near infrared spectroscopy, renal near infrared spectroscopy, pH, pCO2, ionised calcium, and serum lactate were all associated with post-operative length of stay.Conclusion:Discrete clinical and haemodynamic factors upon paediatric cardiac ICU admission after staged Yasui completion are associated with post-operative length of stay. Clinical target ranges can be developed and seem consistent with the notion that greater systemic oxygen delivery is associated with lower post-operative length of stay.
Web-based support for spouses of patients with life-threatening illness cared for in specialized home care – A feasibility study
Authors: Tibell Louise Häger , Alvariza Anette , Kreicbergs Ulrika , Wallin Viktoria , Steineck Gunnar , Holm Maja 
Published: December 2022

AbstractObjectivesPsychoeducational interventions for family caregivers have shown to be effective but not possible for all caregivers to attend; thus, web-based interventions may be a complement. This study aimed to evaluate feasibility of a web-based intervention, “narstaende.se,” from the perspective of spouses of patients receiving specialized home care.MethodsA website was developed, containing videos with conversations between health-care professionals and family caregivers (actors), informative texts, links to further information, and a chat forum. The aim of the website is to provide support and promote preparedness for caregiving and death, and the content is theoretically and empirically grounded. The study had a descriptive cross-sectional design. Altogether, 26 spouses answered a questionnaire, before accessing the website, and 4 weeks after this, 12 spouses were interviewed. Descriptive statistics and qualitative content analysis were used.ResultsSpouses experienced the website as being easy to use, welcoming, and with relevant content. Participating spouses would recommend “narstaende.se” to others in similar situations, and the majority found the website introduced timely. Videos seemed easily accessible and were most used, contributing to a feeling of recognition and sharing the situation. The online format was perceived as flexible, but still not all spouses visited the website, stating the desire for support in real life.Significance of resultsA web-based intervention can be feasible for spouses in specialized home care; however, the digital format is not suitable for everyone. Further research is needed to determine the website’s potential to provide support and increase preparedness for family caregivers in general.
Quantitative Mineral Analysis of Ordinary Chondrites and Primitive Achondrites Using Reflectance Spectroscopy
Authors: Wang PengYue , Cloutis Edward , Zhang QinWei , Wu YunZhao 
Published: December 2022

AbstractVisible and near‐infrared spectroscopy is a widely used method to determine the mineral compositions of meteorites and asteroids. In this study, we first investigated the association of multiple spectral parameters with mineral compositions using published laboratory spectra and mineral analysis of ordinary chondrites and primitive achondrites. New models for deriving the abundances of mafic silicate minerals were determined. Second, the influence of different mineral compositions on the 1.25 μm region is discussed. Finally, a method to distinguish the ordinary chondrites from primitive achondrites is developed. Our results suggest that the 1.25–1 μm band depth ratio (BDR 1.25) and 1 μm band width (BW I) are mainly associated with mineral abundances and to a lesser extent, compositions. Olivine is the dominant mafic mineral phase that affects the 1.25 μm region in ordinary chondrites and primitive achondrites. The plot of the BDR 1.25 versus the BW I is a useful method for correctly distinguishing about 90% of the primitive achondrites from ordinary chondrites. It relies largely on differences in olivine abundance and olivine/pyroxene ratios and to a lesser extent, olivine composition. The quantitative mineral analysis in this study based on the correlation between the spectra and mineralogy of ordinary chondrites and primitive achondrites provides a chance for understanding the petrology and geochemistry of S‐type asteroids. This study can also distinguish the partially melted S‐type asteroids (parent body of primitive achondrites) from the unmelted S‐type asteroids (parent body of ordinary chondrites).
Linear Stochastic Analysis of the Partial Reversibility of Ensemble and Effective Dispersion in Heterogeneous Porous Media
Authors: Stettler Marie‐Madeleine , Dentz Marco , Cirpka Olaf A. 
Published: December 2022

AbstractMacrodispersion in heterogeneous formations is caused by spatial variability of the velocity field, making different parts of a plume experience different advective displacements. Differential advection interacts with diffusion, which hardly affects longitudinal ensemble dispersion (i.e., the spread of the ensemble‐averaged concentration) but determines effective dispersion, that is, the expected spread of individual plumes for point injections. The latter has been suggested as metric of solute mixing. Pure advection is fully reversible, whereas diffusion is completely irreversible. We quantify the partial reversibility of macrodispersion by analyzing the second central ensemble and effective spatial moments for advective‐diffusive transport in heterogeneous domains with flow reversal, applying linear stochastic theory to approximate the corresponding moments and comparing them to particle‐tracking random‐walk simulations in periodic media. Diffusion causes solute particles to deviate from their forward trajectories when flow is reversed. As long as advective memory dominates, both types of second central moments decrease during backward motion, then reach a minimum, and increase again. The reversibility is considerably bigger for ensemble than effective dispersion but the latter also shows partial reversibility, challenging its use as metric of mixing. The stronger diffusion is in comparison to advection, the less reversible dispersion becomes. After equally long times of forward and backward motion, the two types of second central moments differ, but to a much smaller extent than in pure forward motion. In realistic settings, the advective memory affects dispersion so strongly that the asymptotic regime is not reached before the plume center has returned to its origin.
Regulation of programmed cell death by Brd4
Authors: Hu Jinfeng , Pan Dun , Li Guo , Chen Kunqi , Hu Xiangming 
Published: December 2022

AbstractEpigenetic factor Brd4 has emerged as a key regulator of cancer cell proliferation. Targeted inhibition of Brd4 suppresses growth and induces apoptosis of various cancer cells. In addition to apoptosis, Brd4 has also been shown to regulate several other forms of programmed cell death (PCD), including autophagy, necroptosis, pyroptosis, and ferroptosis, with different biological outcomes. PCD plays key roles in development and tissue homeostasis by eliminating unnecessary or detrimental cells. Dysregulation of PCD is associated with various human diseases, including cancer, neurodegenerative and infectious diseases. In this review, we discussed some recent findings on how Brd4 actively regulates different forms of PCD and the therapeutic potentials of targeting Brd4 in PCD-related human diseases. A better understanding of PCD regulation would provide not only new insights into pathophysiological functions of PCD but also provide new avenues for therapy by targeting Brd4-regulated PCD.
Exceptional preservation and foot structure reveal ecological transitions and lifestyles of early theropod flyers
Authors: Pittman Michael , Bell Phil R. , Miller Case Vincent , Enriquez Nathan J. , Wang Xiaoli , Zheng Xiaoting , Tsang Leah R. , Tse Yuen Ting , Landes Michael , Kaye Thomas G. 
Published: December 2022

AbstractMorphology of keratinised toe pads and foot scales, hinging of foot joints and claw shape and size all inform the grasping ability, cursoriality and feeding mode of living birds. Presented here is morphological evidence from the fossil feet of early theropod flyers. Foot soft tissues and joint articulations are qualitatively assessed using laser-stimulated fluorescence. Pedal claw shape and size are quantitatively analysed using traditional morphometrics. We interpret these foot data among existing evidence to better understand the evolutionary ecology of early theropod flyers. Jurassic flyers like Anchiornis and Archaeopteryx show adaptations suggestive of relatively ground-dwelling lifestyles. Early Cretaceous flyers then diversify into more aerial lifestyles, including generalists like Confuciusornis and specialists like the climbing Fortunguavis. Some early birds, like the Late Jurassic Berlin Archaeopteryx and Early Cretaceous Sapeornis, show complex ecologies seemingly unique among sampled modern birds. As a non-bird flyer, finding affinities of Microraptor to a more specialised raptorial lifestyle is unexpected. Its hawk-like characteristics are rare among known theropod flyers of the time suggesting that some non-bird flyers perform specialised roles filled by birds today. We demonstrate diverse ecological profiles among early theropod flyers, changing as flight developed, and some non-bird flyers have more complex ecological roles.
A robust energy management system for Korean green islands project
Authors: Tightiz Lilia , Yoo Joon 
Published: December 2022

AbstractPenetration enhancement of renewable energy sources is a core component of Korean green-island microgrid projects. This approach calls for a robust energy management system to control the stochastic behavior of renewable energy sources. Therefore, in this paper, we put forward a novel reinforcement learning-driven optimization solution for the convex problem arrangement of the Gasa island microgrid energy management as one of the prominent pilots of the Korean green islands project. We manage the convergence speed of the alternating direction method of multipliers solution for this convex problem by accurately estimating the penalty parameter with the soft actor-critic technique. However, in this arrangement, the soft actor-critic faces sparse reward hindrance, which we address here with the normalizing flow policy. Furthermore, we study the effect of demand response implementation in the Gasa island microgrid to reduce the diesel generator dependency of the microgrid and provide benefits, such as peak-shaving and gas emission reduction.
Reliability of crowdsourced data and patient-reported outcome measures in cough-based COVID-19 screening
Authors: Xiong Hao , Berkovsky Shlomo , Kâafar Mohamed Ali , Jaffe Adam , Coiera Enrico , Sharan Roneel V. 
Published: December 2022

AbstractMass community testing is a critical means for monitoring the spread of the COVID-19 pandemic. Polymerase chain reaction (PCR) is the gold standard for detecting the causative coronavirus 2 (SARS-CoV-2) but the test is invasive, test centers may not be readily available, and the wait for laboratory results can take several days. Various machine learning based alternatives to PCR screening for SARS-CoV-2 have been proposed, including cough sound analysis. Cough classification models appear to be a robust means to predict infective status, but collecting reliable PCR confirmed data for their development is challenging and recent work using unverified crowdsourced data is seen as a viable alternative. In this study, we report experiments that assess cough classification models trained (i) using data from PCR-confirmed COVID subjects and (ii) using data of individuals self-reporting their infective status. We compare performance using PCR-confirmed data. Models trained on PCR-confirmed data perform better than those trained on patient-reported data. Models using PCR-confirmed data also exploit more stable predictive features and converge faster. Crowd-sourced cough data is less reliable than PCR-confirmed data for developing predictive models for COVID-19, and raises concerns about the utility of patient reported outcome data in developing other clinical predictive models when better gold-standard data are available.
What makes the unsupervised monocular depth estimation (UMDE) model training better
Authors: Wang Xiangtong , Liang Binbin , Yang Menglong , Li Wei 
Published: December 2022

AbstractCurrent computer vision tasks based on deep learning require a huge amount of data with annotations for model training or testing, especially in some dense estimation tasks, such as optical flow segmentation and depth estimation. In practice, manual labeling for dense estimation tasks is very difficult or even impossible, and the scenes of the dataset are often restricted to a small range, which dramatically limits the development of the community. To overcome this deficiency, we propose a synthetic dataset generation method to obtain the expandable dataset without burdensome manual workforce. By this method, we construct a dataset called MineNavi containing video footages from first-perspective-view of the aircraft matched with accurate ground truth for depth estimation in aircraft navigation application. We also provide quantitative experiments to prove that pre-training via our MineNavi dataset can improve the performance of depth estimation model and speed up the convergence of the model on real scene data. Since the synthetic dataset has a similar effect to the real-world dataset in the training process of deep model, we finally conduct the experiments on MineNavi with unsupervised monocular depth estimation (UMDE) deep learning models to demonstrate the impact of various factors in our dataset such as lighting conditions and motion mode, aiming to explore what makes this kind of models training better.
Pilot study on the use of cold atmospheric plasma for preservation of bread
Authors: Starek-Wójcicka Agnieszka , Różyło Renata , Niedźwiedź Iwona , Kwiatkowski Michał , Terebun Piotr , Polak-Berecka Magdalena , Pawłat Joanna 
Published: December 2022

AbstractCold atmospheric plasma (CAP) is used as an emerging technology for food preservation. In this study, CAP treatment has been applied to bakery products for the first time. The aim of the work was to investigate the effect of the use of CAP on the amount of microorganisms during bread storage. Basic physicochemical properties and bread texture were determined during storage for 0, 3, and 6 days. The study material included gluten-free and mixed wheat-rye bread treated with CAP for 2 and 10 min. The results showed that no mesophilic bacteria or fungi were found after ten minutes of the bread exposure to CAP. In addition, only 2-min non-thermal sterilization resulted in complete inhibition of yeast and mould growth in the gluten-free and wheat-rye bread. A decrease in the microbial growth in the bread was noted; however, a simultaneous decrease in the moisture content of the bread was observed. After the application of plasma for 2 or 10 min, both the gluten-free and mixed wheat-rye bread was characterized by reduced humidity, which also resulted in a significant increase in the hardness and a slight increase in the springiness of the bread. The use of CAP in storage of bread is promising; nevertheless, it is necessary to further study the effect of this treatment in bread with improvers, especially with hydrocolloids and fibers.
Listeria-vectored multi-antigenic tuberculosis vaccine protects C57BL/6 and BALB/c mice and guinea pigs against Mycobacterium tuberculosis challenge
Authors: Jia Qingmei , Masleša-Galić Saša , Nava Susana , Horwitz Marcus A. 
Published: December 2022

AbstractMycobacterium tuberculosis (Mtb) infects one-third of the world’s population and is a leading cause of death from a single infectious agent. New TB vaccines are urgently needed to augment immunity conferred by the current modestly protective BCG vaccine. We have developed live attenuated recombinant Listeria monocytogenes (rLm)-vectored TB vaccines expressing five [Mpt64/23.5-EsxH/TB10.4-EsxA/ESAT6-EsxB/CFP10-Ag85B/r30] (rLmMtb5Ag) or nine (additionally EsxN-PPE68-EspA-TB8.4) immunoprotective Mtb antigens (rLmMtb9Ag) and evaluated them for safety, immunogenicity and efficacy as standalone vaccines in two mouse models and an outbred guinea pig model. In immunogenicity studies, rLmMtb5Ag administered subcutaneously induces significantly enhanced antigen-specific CD4+ and CD8+ T-cell responses in C57BL/6 and BALB/c mice, and rLmMtb9Ag induces antigen-specific CD4+ and CD8+ T-cell proliferation in guinea pigs. In efficacy studies, both rLmMtb5Ag and rLmMtb9Ag are safe and protect C57BL/6 and BALB/c mice and guinea pigs against aerosol challenge with highly virulent Mtb. Hence, multi-antigenic rLm vaccines hold promise as new vaccines against TB.