bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Resveratrol in Aging and Senescence: A Focus on
Molecular Mechanisms
Authors: Kohandel Zeynab , Darrudi Majid , Naseri Kobra , Samini Fariborz , Aschner Michael , Pourbagher-Shahri Ali Mohammad , Samarghandian Saeed 
Published: June 2023

Abstract:
Resveratrol (Res), a polyphenol found in red wine, has been shown to
decelerate aging, the progressive loss of physiological integrity and cellular senescence,
characterized by the inability to progress through the cell cycle. No successful clinical
trials have yet to be completed in humans on dose limitations. Yet, the potent anti-aging
and anti-senescence efficacy of Res has been documented in several in vivo animal
models. In this review, we highlight the molecular mechanisms of Res efficacy in antiaging
disorders, such as diabetes, neurodegenerative disorders, eye diseases, and
cardiovascular diseases.
Disrupted Balance of Gray Matter Volume and Directed Functional Connectivity
in Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Xiong Yu , Ye Chenghui , Sun Ruxin , Chen Ying , Zhong Xiaochun , Zhang Jiaqi , Zhong Zhanhua , Chen Hongda , Huang Min 
Published: June 2023

Background:
Alterations in functional connectivity have been demonstrated in Alzheimer’s
disease (AD), an age-progressive neurodegenerative disorder that affects cognitive function;
however, directional information flow has never been analyzed.

Objective:
This study aimed to determine changes in resting-state directional functional connectivity
measured using a novel approach, granger causality density (GCD), in patients with AD, and mild
cognitive impairment (MCI) and explore novel neuroimaging biomarkers for cognitive decline detection.

Methods:
In this study, structural MRI, resting-state functional magnetic resonance imaging, and neuropsychological
data of 48 Alzheimer’s Disease Neuroimaging Initiative participants were analyzed,
comprising 16 patients with AD, 16 with MCI, and 16 normal controls. Volume-based morphometry
(VBM) and GCD were used to calculate the voxel-based gray matter (GM) volumes and directed
functional connectivity of the brain. We made full use of voxel-based between-group comparisons of
VBM and GCD values to identify specific regions with significant alterations. In addition, Pearson’s
correlation analysis was conducted between directed functional connectivity and several clinical variables.
Furthermore, receiver operating characteristic (ROC) analysis related to classification was performed
in combination with VBM and GCD.

Results:
In patients with cognitive decline, abnormal VBM and GCD (involving inflow and outflow
of GCD) were noted in default mode network (DMN)-related areas and the cerebellum. GCD in the
DMN midline core system, hippocampus, and cerebellum was closely correlated with the Mini-
Mental State Examination and Functional Activities Questionnaire scores. In the ROC analysis combining
VBM with GCD, the neuroimaging biomarker in the cerebellum was optimal for the early detection
of MCI, whereas the precuneus was the best in predicting cognitive decline progression and
AD diagnosis.

Conclusion:
Changes in GM volume and directed functional connectivity may reflect the mechanism
of cognitive decline. This discovery could improve our understanding of the pathology of AD and
MCI and provide available neuroimaging markers for the early detection, progression, and diagnosis
of AD and MCI.
Integrated Single-cell and Bulk RNA Sequencing Analysis Cross Talk
between Ferroptosis-related Genes and Prognosis in Oral Cavity Squamous
Cell Carcinoma
Authors: Lan Tianjun , Ren Siqi , Hu Huijun , Wang Ruixin , Chen Qian , Wu Fan , Xu Qiuping , Li Yanyan , Shao Libin , Wang Liansheng , Liu Xin , Cao Haotian , Li Jinsong 
Published: June 2023

Background:
Ferroptosis is a new type of programmed apoptosis and plays an important
role in tumour inhibition and immunotherapy.

Objective:
In this study, we aimed to explore the potential role of ferroptosis-related genes (FRGs)
and the potential therapeutic targets in oral cavity squamous cell carcinoma (OCSCC).

Methods:
The transcription data of OCSCC samples were obtained from the Cancer Genome Atlas
(TCGA) database as a training dataset. The prognostic FRGs were extracted by univariate Cox
regression analysis. Then, we constructed a prognostic model using the least absolute shrinkage
and selection operator (LASSO) and Cox analysis to determine the independent prognosis FRGs.
Based on this model, risk scores were calculated for the OCSCC samples. The model’s capability
was further evaluated by the receiver operating characteristic curve (ROC). Then, we used the
GSE41613 dataset as an external validation cohort to confirm the model’s predictive capability.
Next, the immune infiltration and somatic mutation analysis were applied. Lastly, single-cell transcriptomic
analysis was used to identify the key cells.

Results:
A total of 12 prognostic FRGs were identified. Eventually, 6 FRGs were screened as independent
predictors and a prognostic model was constructed in the training dataset, which significantly
stratified OCSCC samples into high-risk and low-risk groups based on overall survival.
The external validation of the model using the GSE41613 dataset demonstrated a satisfactory predictive
capability for the prognosis of OCSCC. Further analysis revealed that patients in the highrisk
group had distinct immune infiltration and somatic mutation patterns from low-risk patients.
Mast cell infiltrations were identified as prognostic immune cells and played a role in OCSCC
partly through ferroptosis.

Conclusion:
We successfully constructed a novel 6 FRGs model and identified a prognostic immune
cell, which can serve to predict clinical prognoses for OCSCC. Ferroptosis may be a new
direction for immunotherapy of OCSCC.
Seismic displacement prediction methods, procedure, comparison and application
Authors: Rojas Gomez Luis Felipe , Ortiz Galindo Lesly Scarlet , Cabrera Conislla Jesús Andrés 
Published: June 2023

The methodology in the seismic design of slopes has evolved with technological advancement and the development of geotechnical engineering. Since methods with great limitations such as pseudo-static analysis to rigorous methods that require a lot of information for a better understanding of the behavior of the soil such as the dynamic analysis.
This article develops the procedure, comparison, and application of methods for estimating seismic displacements, which are the Newmark (1965), Sarma (1975), Makdisi & Seed (1978) and Bray, Macedo & Travasarou (2018). Each of these methods considering the criteria of each one to obtain permanent displacements, such as yield acceleration, degraded period, spectral acceleration, magnitude, etc.
As an applicative case, a rockfill dam and core central 50 m high placed in sandstone strata and moraine deposits interspersed with shale intrusions is shown, as seismic scenarios the Lima 1974 earthquake, the Attic 2001 earthquake and the earthquake were used. of Pisco 2007, considering both NS and EW directions. Likewise, the response spectrum on the base of the failure surface, resulting from a nonlinear seismic response analysis from 3 columns in the dam, is considered as information. The methods of Newmark (1965), Sarma (1975), Makdisi & Seed (1978), and Bray, Macedo & Travasarou (2018) were applied, obtaining deformation results between 1 to 30 cm that according to their order of magnitude represent a stable condition for the dam.
Optimasi Konsentrasi Sukrosa dan Propilen Glikol dalam Formulasi Chewable Gummy Tablet Ekstrak Daun Kelor (Moringa oleifera L)
Authors: Rani Karina Citra , Nikmatul Ikhrom Eka Jayani  , Maulidia Setaratika  , Syalza Mumpuni Kusuma Dewi  
Published: June 2023

Latar Belakang: Moringa leaves extract is promising to develop into nutraceutical products, especially a chewable gummy. The desirable characteristics of chewable gummies are soft, elastic, springy, and flexible. Gelatin is a widely used gelling agent which has been proven to maintain gel structure during storage. The other ingredients which also determine the chewable gel structure are filler and plasticizer. The aim of this study was to determine the effect of sucrose and propylene glycol concentration on Moringa leaves extract based chewable gummy. Metode: The preparation of chewable gummy tablets was conducted by the pour method. Factorial design study (22) was applied in this study to analyze the effect of two factors herein filler and plasticizer. Two levels of concentration were optimized in each factor, herein sucrose (30% and 35% concentration) and propylene glycol (2% and 4% concentration) on the physical characteristics of the gummy tablet. Hasil: The results of the factorial analysis showed that the increase in sucrose concentration will produce a longer dispersion time and lower swelling ratio. Meanwhile, the increase in propylene glycol decreases the syneresis potency. The alteration of physical characteristics was observed during 14 days of storage, particularly in dispersion time, swelling ratio, and syneresis percentage. Kesimpulan: Based on the results of feasible design space, sucrose concentration (30-35%) and propylene glycol concentration (2-4%) optimized in this study produce the desirable characteristics of chewable gummy.
Molecular and biochemical characterization of solid waste biodegrading microbes isolated from municipal waste dump site
Authors: Afshan Naheed , Ghouri Maham , Hayat Aliya , Nadeem Sayyada Ghufrana 
Published: June 2023

Solid waste dump site-based pollution is one of the colossal health concerns globally due to presence of cellulose, starch, protein, and lipids, which is a perfect nutrient waste for the development of biodegrading potential microbes. The current study aimed to determine the productive microorganisms for waste biodegradation. Ten samples were collected from different areas of Karachi waste dump sites. The identification and characterization of isolates were done by morphological and biochemical tests. The isolated microbes were qualitatively screened for the action of making industrially key bio-enzymes. The potential enzymes producing microbes were subjected to waste degradation test for 90 days. Changes of odor, color and weight loss of decomposing garbage were noted. The highest degradation ability in term of weight loss was shown by Aspergillus (SSI14) and Bacillus (SSI6). Four metals (zinc sulphate, cadmium chloride, copper sulphate and iron sulphate) were chosen for the purpose of metals tolerance test and minimum inhibitory concentration (MIC) of the isolated microbial strains. Current study reported that Zn was found to be more lethal in in comparison to Cu and Fe. Molecular identification of the isolated microbes was done by polymerase chain reaction. The microbial strains were characterized by the polymerase chain reaction (PCR) followed by confirmation of product by agarose gel electrophoresis. The findings can be served as baseline data to develop microbial apparatus for biodegradation and management of solid waste.
Perfil Antropométrico y composición corporal en Futbolistas de Elite Ecuatorianos según su posición de juego
Authors: Álvarez Córdova Ludwig Roberto 
Published: June 2023

Introducción: La cineantropometría en deportistas es imprescindible para la valoración cuantitativa de su Composición Corporal (CC) y nutricional, llevándonos a una percepción personalizada permitiendo establecer objetivos y estrategias que convergen en el entrenamiento y la dieta, con el fin de conseguir el éxito deportivo. Objetivo: Describir las caracteristicas antropométricas, la CC y el somatotipo específico por posición de juego en futbolistas profesionales de la primera división del Ecuador, con el propósito de establecer patrones antropométricos, que permitan en un futuro referenciar a la población de futbolistas y que pueda ser comparado con otros equipos profesionales Método: Se analizaron las variables antropometricas según protocol ISAK, de 30 futbolistas profesionales masculinos de un equipo de primera de la liga ecuatoriana de fútbol, evaluándose el somatotipo según Heath-Carter y su CC cálculándose la Masa Grasa (MG) de Yuhaz modificada por Carter y el cálculo de la Masa Libre de Grasa (MLG) y Masa Muscular (MM) por Lee; empleándose una estadística descriptiva (media±desviación estándar (Ds)) a través de SPSS 25.0 aplicando t- Student bilateral pareada (two-tailed paired t test) (P<0.005). Resultados: Los valores medios obtenidos son estatura (179±5,1 cm), peso (78±7,1 Kg), y la edad (25±5 años), siendo de mayor edad los centrocampistas y los de mayor altura los porteros y delanteros. Con respecto al IMC se obtuvo un valor de 24,9±2,2, siendo el valor medio de porcentaje de grasa corporal (%GC) de 13,1±3,3%, teniendo un valor superior los porteros y los defensas en menor proporción; con MLG 45,2 ±1,7%, con MG (9,8±2,9 Kg) y MM (66±,8Kg). El somatotipo es mesomorfo balanceado en todas las posiciones de juego (1,8 - 5,4 - 1,8). Discusión: Según su posición de juego, no existe diferencia entre los somatotipos con y con una CC acorde a lo publicado en este deporte deporte practicado.
Organization of foreign language adaptation training in a technical university during the pandemic
Authors: Маркова Наталия Александровна 
Published: June 2023

Рассматриваются вопросы организации адаптационной иноязычной подготовки в российском техническом вузе в период пандемии COVID-19. Автор полагает, что общие объективные изменения вынужденного дистанционного образовательного процесса также характерны и для адаптационного обучения. Выявлены противоречия, возникшие в период обязательного дистанционного обучения и препятствующие достижению ожидаемых результатов в адаптационном обучении английскому языку на примере Томского политехнического университета. Обосновывается необходимость более углубленного изучения механизмов и принципов адаптационного обучения. Подчеркивается важность определения ключевых моментов, которые обеспечили успешное педагогическое сопровождение адаптационного курса в период пандемии. Делается вывод о том, что цифровая трансформация российской системы образования неизбежна, однако необходимо задуматься о системном подходе к построению новой образовательной среды.
In connection with the threat of the spread of a new coronavirus in March 2020, all Russian universities had to switch to a distance learning format. The mass transition to a distance format of training has revealed a number of problems and contradictions in the possibilities of implementing higher education programs in a distant form. This required a deep and detailed analysis of different aspects of distance training, the readiness of all participants in the educational process, the availability of material, technical and methodological support. The article considers the issues of organization of Foreign Language adaptation training in a technical university during the COVID-19 pandemic. The author believes that the general objective changes of compulsory distance training process are also typical for Foreign Language adaptation training. The contradictions emerged in this period are revealed on the example of Tomsk Polytechnic University. The article gives proof of the necessity of more in-depth study of the adaptation training mechanisms and principles. The importance of identifying the key points that ensured successful pedagogical support of adaptation course during the pandemic is emphasized. The conclusion is made that the digital transformation of the Russian education system is inevitable, but it is necessary to think about a systematic approach to building a new educational environment.
The essence and specifics of pedagogical support for preschool children with special educational needs
Authors: Акулова Елена Геннадьевна 
Published: June 2023

В статье описана специфика педагогического сопровождения детей дошкольного возраста. Представлены теоретическое обоснование и методологические подходы педагогического сопровождения, его практическая значимость. Выделены сущностные характеристики, обозначены смыслы и значение педагогического сопровождения в дошкольном образовании. Выдвинут принцип диверсификации педагогического сопровождения и показана его взаимообусловленность с вариативностью образования в дошкольных организациях. Классифицированы основные процессы взаимодействия педагога и ребенка и отмечена динамика изменений в системе сопровождения дошкольников в связи с появлением в массовых образовательных учреждениях детей с особенностями в развитии. Дано расширенное понимание термина «дети с особыми образовательными потребностями» с позиции поддержки многообразия детства. Представлена классификация категорий детей с особыми образовательными потребностями, обучающихся в российских дошкольных организациях. Определены необходимые условия и перспективы развития педагогического сопровождения дошкольников с особыми образовательными потребностями в рамках вариативного социокультурного образовательного пространства.
The article describes the specifics of pedagogical support for preschool children. The theoretical substantiation and methodological approaches of pedagogical support, its practical significance are presented. The meanings and significance of the phenomenon are indicated, the essential characteristics of pedagogical support in preschool education are highlighted. The topic of personalization of education, development, upbringing of children with various starting opportunities is updated. The principle of diversification of pedagogical support is put forward and its interdependence with variability as an actual quality of Russian education is proved. The main processes of interaction between a teacher and a child are classified and the dynamics of changes in the system of support for preschoolers in connection with the appearance of children with developmental disabilities in mass educational institutions is shown. The term “children with special educational needs” is presented, which is disclosed from the position of supporting the diversity of childhood. Classification of categories of children with special educational needs studying in Russian preschool organizations has been developed. The necessary conditions and prospects for the development of pedagogical support for preschoolers with special educational needs within the framework of a multivariate socio-cultural educational space are determined.
The Impact of Oral Health on Severity of COVID-19 Infection: A Cross-sectional Study of Recovered Patients in Syria
Authors: Mohamad Nebras 
Published: June 2023

Purpose: This study aimed to investigate the role of oral health in determining the severity of COVID-19 infection among recovered COVID-19 Syrian patients.
Clinical Significance: The severity of COVID-19 infection varies among individuals, and the general health status of individuals plays a crucial role in determining the severity of symptoms. The association between oral health and COVID-19 severity has not been widely explored. Understanding the impact of oral health on COVID-19 severity can help in developing strategies to prevent severe and aggressive COVID-19 infection.
Material and Methods: A cross-sectional trial based on a questionnaire survey was conducted among 319 recovered COVID-19 Syrian patients. The questionnaire was divided into two main sections: oral health evaluation and COVID-19 severity assessment. Participants were classified into three groups based on their responses for oral health and COVID-19 severity.
Results: Our observations revealed a significant difference between overall health and the severity of COVID-19 infection. Participants with worse general health had higher COVID-19 severity index scores. Patients with chronic conditions also had a considerably higher prevalence of COVID-19 severity index. Furthermore, our findings suggest that individuals with poor overall health and chronic diseases exhibited the worst oral health. However, there was no relationship between oral health status and the recovery period of COVID-19 infection. The association between oral health status and COVID-19 severity index revealed a positive correlation, although it was not statistically significant.
Conclusions: Our study provides evidence that the oral cavity and its components may contribute to an elevated risk of COVID-19 infection, as the association between COVID-19 severity and oral health status revealed a positive correlation, although it was not statistically significant. Further research with larger sample sizes and more reliable study designs will be required to confirm our findings. In the light of our findings, we recommend following simple oral health measures such as tooth brushing, regular dental check-ups, and periodontal screening to prevent severe and aggressive COVID-19 infection.
In vitro Antimicrobial Activities, Qualitative Phytochemical Screening, and Free Radical Scavenging Capacities of Gymnanthemum myrianthum
Authors: Zacchaeus Rotich K. , Richard Kagia 
Published: June 2023

Various members of the genus Vernonia are commonly used in traditional medicine to treat fever, malaria, diarrhoea, dysentery, hepatitis, cough, fertility inducer and as a laxative. Vernonia myrianthum (Gymnanthemum myrianthum) is one of the medicinal plants used by traditional healers in Uasin-Gishu and Elgeiyo Marakwet counties to treat communicable and non-communicable diseases such as diabetes mellitus. The objectives of this study were to evaluate the phytochemicals, free radical scavenging capacity and antimicrobial activities of the methanolic root extract of Vernonia myrianthum. Standard phytochemical screening methods were employed to qualitatively evaluate the classes of phytochemicals present in the plant. The anti-oxidant capacity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The disc diffusion method and minimum inhibitory concentration (MIC) were used to screen for antimicrobial activity against Escherichia coli and Staphylococcus aureus. Vernonia myrianthum was found to contain secondary metabolites such as alkaloids, flavonoids, tannins, terpenoids, carotenoids, and coumarin. The antioxidant activity on the extract as based on its IC50 values indicated good antioxidant activity. There was no significant difference (p≥0.01) between the zones of inhibition of Vernonia myrianthum and those of those of the positive control gentamycin (GEN, at 10 mcg) and amoxicillin (AMC, 30 mcg) at various test concentrations demonstrating that V. myrianthum could inhibit the growth of E. coli and S. aureus. The findings of this study are critical in understanding and documenting the phytochemistry, the antimicrobial properties and the antioxidant capabilities of V. myrianthum thus, laying the groundwork for future research on isolating bioactive compounds from these plants, as well as building the body of evidence needed to justify the ethnomedicinal usage of this plant in the treatment of numerous diseases by different communities.