bluuebunny/crossref_metadata_2025_split huggingface dataset:
The strengths and complexities of European registries concerning paediatric kidney transplantation health care
Authors: Oomen Loes , De Wall Liesbeth L. , Krupka Kai , Tönshoff Burkhard , Wlodkowski Tanja , Van Der Zanden Loes FM , Bonthuis Marjolein , Duus Weinreich Ilse D. , Koster-Kamphuis Linda , Feitz Wout FJ , Bootsma-Robroeks Charlotte MHHT 
Published: March 2023

IntroductionPatient data are increasingly available in (multi)national registries, especially for rare diseases. This study aims to provide an overview of current European registries of paediatric kidney transplantation (PKT) care, their coverage, and their focus. Based on these data, we assess whether the current status is optimal for achieving our common goal: the optimalisation of health care.MethodsA list of all PKT centres within the European Union (EU) as well as active PKT registries was compiled using existing literature and the European Platform on Rare Disease Registration. Registry staff members were contacted to obtain information about the parameters collected and the registry design. These data were compared between registries.ResultsIn total, 109 PKT centres performing PKT surgery were identified in the 27 EU Member States. Currently, five European PKT registries are actively collecting data. In 39% of these centres, no data were registered within any of these five existing international registries. A large variety was observed in the number of patients, centres, and countries involved in the registries. Furthermore, variability existed regarding the inclusion criteria, definitions used, and parameters collected. Collection of perioperative urologic data are currently underrepresented in the registries.DiscussionCurrently, multiple registries are collecting valuable information in the field of PKT, covering the majority of PKT centres in Europe. Due to a large variety in the parameters collected as well as different focuses, data collection is currently fragmented and suboptimal; therefore, the current existing data are incomplete. In addition, a considerable proportion of the transplantation centres do not enter data in any international registry. Combining available information and harmonising future data collection could empower the aim of these registries—namely increasing insights into the strengths and potential of current care and therefore improve healthcare
Optimisation of alpha-amylase inhibitor production in solid state fermentation
Authors: Fatoki O. A. , Onilude A. A. , Ekanola Y. A. , Akanbi C. T. 
Published: March 2023

Though not a known producer of alpha-amylase inhibitor, the potential of Streptomyces xinghaiensis AAI-2 to produce this important metabolite was assessed and the process optimised in solid substrate using response surface methodology. The isolate was grown in an inoculum medium, inoculated into wheat bran and supplemented with a basal medium for production of alpha amylase inhibitor. Optimum conditions were determined by Response Surface Methodology. The extract was recovered using sodium phosphate buffer at refrigerated temperature and assay for the presence of alpha-amylase inhibitor was carried out by Dinitrosalicylic acid method. Based on the results of the experimental trials and iteration with those values, it was predicted that optimal pH for alpha-amylase inhibitor production using S. xinghaiensis in solid culture of wheat bran was pH 6.4–6.9 while optimal moisture content and incubation time were predicted as 71%–73% and 9–12 days respectively.
Pharmacokinetic comparison of sitagliptin and metformin HCl extended-release tablets versus JANUMET® XR in healthy volunteers under fasting and fed conditions
Authors: Que Linling , Qin Wei , Shi Yunfei , Ding Ying , Huang Kai , Qian Zhenzhong , Huang Bingjie , Zhou Peipei , He Qing 
Published: March 2023

Background and Objectives: Janumet® XR is the combination of sitagliptin and extended metformin hydrochloride produced by Merck Sharp &amp; Dohme. It is specially designed for diabetes mellitus patients taking both drugs already. Janumet® XR exhibited clinically significant blood glucose lowering efficacy and long-term use safety. However, no generic form of Janumet® XR has been approved in western countries. The relatively high cost made the medication less prescribed. A more affordable form of this drug may benefit an immense diabetes mellitus population. The current study compared the bioequivalence (BE) of sitagliptin 100 mg and metformin 1000 mg produced by Nanjing Chia-Tai Tianqing Pharmaceutical Company to Janumet® XR in healthy Chinese subjects.Methods: Twenty-eight healthy Chinese subjects were enrolled in Study 1 and 2, respectively. Both studies were conducted with an open, randomized, two-period crossover design using the test (T) or the reference (R) drug. Study 1 is conducted under the fasting state, and Study 2 is under the fed state. Subjects received an oral dose of sitagliptin 100 mg and metformin 1000 mg, and plasma concentrations of sitagliptin and metformin were determined up to 72 h post-dose. Pharmacokinetic (PK) parameters, including maximum serum concentration (Cmax) and area under the concentration-time curve up to the last quantifiable concentration (AUC0–t) of both sitagliptin and metformin, were calculated and compared between the T and R treatments.Results: In the fasting study, the geometric mean ratios of Cmax, AUC0–t, and AUC0-∞ for sitagliptin were 109.42%, 101.93%, and 101.95%, respectively; the corresponding ratios for metformin were 98.69%, 94.12%, and 93.42%, respectively. In the fed study, the geometric mean ratios of Cmax, AUC0–t, and AUC0-∞ for sitagliptin were 98.41%, 100.30%, and 100.24%, respectively; the corresponding ratios for metformin were 97.79%, 99.28%, and 100.69%, respectively. The 90% CIs of Cmax, AUC0–t, and AUC0-∞ in both studies were all within acceptance limits (80.00%–125.00%).Conclusion: The results demonstrated for the first time that sitagliptin 100 mg and metformin 1000 mg produced by Nanjing Chia-Tai Tianqing Pharmaceutical Company was bioequivalent to the branded Janumet® XR, and both drugs were well tolerated.
Changes in the oxidative status and damage by non-essential elements in the digestive gland of the gastropod Pomacea canaliculata
Authors: Campoy-Diaz Alejandra D. , Malanga Gabriela , Giraud-Billoud Maximiliano , Vega Israel A. 
Published: March 2023

The freshwater gastropod Pomacea canaliculata fulfills the ideal conditions of a bioindicator species since its digestive gland bioconcentrates elements toxic for human and ecosystems health. The aim of this work was to study the balance between production of free radicals and antioxidant defenses, and the generation of oxidative damage in the digestive gland of this mollusk after exposure (96 h) to three elements with differential affinities for functional biological groups: mercury (5.5 μg/L of Hg+2 as HgCl2), arsenic [500 μg/L of (AsO4)−3 as Na3AsO47H2O], or uranium [700 μg/L of (UO2)+2 as UO2(CH2COOH)2]. Bioconcentration factors of Hg, As, and U were 25, 23, and 53, respectively. Snails exhibited a sustained increase of reactive species (RS), and protein and lipid damage. Lipid radicals increased between 72 and 96 h, respectively, in snails exposed to U and Hg while this parameter changed early (24 h) in As- exposed snails. Snails showed protein damage, reaching maximum values at different endpoints. This redox disbalance was partially compensated by non-enzymatic antioxidant defenses α-tocopherol (α-T), β-carotene (β-C), uric acid, metallothionein (MTs). Snails consumed α-T and β-C in an element-dependent manner. The digestive gland consumed rapidly uric acid and this molecule was not recovered at 96 h. Digestive gland showed a significant increase in MTs after elemental exposure at different endpoints. The enzymatic antioxidant defenses, represented by the catalase and glutathione-S-transferase activities, seems to be not necessary for the early stages of the oxidative process by metals. This work is the first attempt to elucidate cellular mechanisms involved in the tolerance of this gastropod to non-essential elements. The bioconcentration factors and changes in the oxidative status and damage confirm that this species can be used as a bioindicator species of metal pollution in freshwater bodies.
Potential mitigation of environmental impacts of intensive plum production in southeast China with maintenance of high yields: Evaluation using life cycle assessment
Authors: Yan Xiaojun , Ye Delian , Tang Yafu , Muneer Muhammad Atif , Christie Peter , Tou Congyue , Xu Weidong , Shen Bingrong , Xu Jinxian , Zhang Jiangzhou 
Published: March 2023

IntroductionIntensive plum production usually involves high yields but also high environmental costs due to excessive fertilizer inputs. Quantitative analysis of the environmental effects of plum production is thereby required in the development of optimum strategies to promote sustainable fruit production.MethodsWe collected survey questionnaires from 254 plum production farms in Zhao’an county, Fujian province, southeast China to assess the environmental impacts by life cycle assessment (LCA) methodology. The farms were categorized into four groups based on yield and environmental impacts, i.e., LL (low yield and low environmental impact), LH (low yield but high environmental impact), HL (high yield but low environmental impact), and HH (high yield and high environmental impact).ResultsThe environmental impacts, i.e., average energy depletion, global warming, acidification, and eutrophication potential in plum production were 18.17 GJ ha-1, 3.63 t CO2 eq ha-1, 42.18 kg SO2 eq ha-1, and 25.06 kg PO4 eq ha-1, respectively. Only 19.7% of farmers were in the HL group, with 13.3% in the HH group, 39.0% in LL, and 28.0% LH. Plum yields of the HL group were 109-114% higher than the mean value of all 254 farms. Additionally, the HL group had a lower environmental impact per unit area compared to the overall mean value, with a reduction ranging from 31.9% to 36.7%. Furthermore, on a per tonne of plum production basis, the energy depletion, global warming potential, acidification potential, and eutrophication potential of HL farms were lower by 75.4%, 75.0%, 75.6%, and 75.8%, respectively. Overall, the total environmental impact index of LL, LH, HL, and HH groups were 0.26, 0.42, 0.06, and 0.21, respectively.DiscussionExcessive fertilizer N application was the main source of the environmental impacts, the potential to reduce fertilizer N rate can be achieved without compromising plum yield by studying the HH group. The results provide an important foundation for enhancing the management of plum production, in order to promote ‘green’ agricultural development by reducing environmental impacts.
The role of psychopathological symptoms in lumbar stenosis: A prediction model of disability after lumbar decompression and fusion
Authors: Mazzucchi Edoardo , La Rocca Giuseppe , Cusumano Davide , Bazzu Paola , Pignotti Fabrizio , Galieri Gianluca , Rinaldi Pierluigi , De Santis Vincenzo , Sabatino Giovanni 
Published: March 2023

IntroductionPre-operative psychological factors may influence outcome after spine surgery. The identification of patients at risk of persisting disability may be useful for patient selection and possibly to improve treatment outcome.MethodsPatients with neurogenic claudication associated with degenerative lumbar spinal stenosis (DLSS) performed a psychological assessment before lumbar decompression and fusion (LDF) surgery. The following tests were administrated: Visual Analogic Scale; Symptom Checklist-90 (SCL-90-R), Short Form-36 and Oswestry Disability Index (ODI). The primary outcome was ODI score lower than 20. A cross correlation matrix (CCM) was carried out with significant variables after univariate analysis and a linear logistic regression model was calculated considering the most significant variable.Results125 patient (61 men and 64 women) were included in the study. Seven parameters of the SCL-90-R scale showed statistical significance at the univariate analysis: obsessivity (p &lt; 0.001), Current Symptom Index (p = 0.001), Global Severity Index (p &lt; 0.001), depression (p &lt; 0.001), positive Symptom Total (p = 0.002), somatization (p = 0.001) and anxiety (p = 0.036). Obsessivity was correlated with other significant parameters, except GSI (Pearson’s correlation coefficient = 0.11).The ROC curve for the logistic model considering obsessivity as risk factor, has an area under the curve of 0.75.ConclusionPre-operative psychopathological symptoms can predict persistence of disability after LDF for DLSS. Future studies will evaluate the possibility of modifying post operative outcome through targeted treatment for psychological features emerged during pre-operative assessment.
Adjunctive transcranial alternating current stimulation for patients with major depressive disorder: A systematic review and meta-analysis
Authors: Zheng Wei , Cai Dong-Bin , Nie Sha , Chen Jian-Hua , Huang Xing-Bing , Goerigk Stephan , Brunoni Andre Russowsky , Zheng Wei 
Published: March 2023

ObjectiveWe performed a meta-analysis of randomized, double-blind, controlled trials (RCTs) to systematically investigate the therapeutic effects and tolerability of transcranial alternating current stimulation (tACS) for the treatment of patients with major depressive disorder (MDD).MethodsElectronic search of PubMed, PsycINFO, EMBASE, Chinese National Knowledge Infrastructure, Wanfang database, and the Cochrane Library up to 1 April 2022. Double-blind RCTs examining the efficacy and safety of tACS for patients with MDD were included. The primary outcome was the improvement of depressive symptoms following a course of tACS treatment. Data were analyzed using Review Manager Version 5.3 (Cochrane IMS, Oxford, UK). Study quality was assessed using the Cochrane risk of bias and Jadad scale. Publication bias was assessed using a funnel plot and the Egger test.ResultsWe identified 883 articles, of which 4 RCTs with 5 active treatment arms covering 224 participants with MDD on active tACS (n = 117) and sham tACS (n = 107) were eligible for inclusion. Meta-analysis of depressive symptoms at post-tACS found an advantage of active tACS over sham tACS (n = 212, standard mean difference (SMD) = −1.14, 95% confidence interval (CI): −2.23, −0.06; I2 = 90%, P = 0.04). The significant superiority of active tACS over sham tACS in improving depressive symptoms remained in a sensitivity analysis. Active tACS was significantly superior to sham tACS regarding depressive symptoms at the 4 week follow-up (SMD = −1.07, 95% CI: −2.05, −0.08; I2 = 88%, P = 0.03) and study-defined remission [risk ratio (RR) = 2.07, 95% CI: 1.36, 3.14, I2 = 9%, P = 0.0006]. The discontinuation rate due to any reason was similar between the two groups (P &gt; 0.05). All included studies were rated as high quality (Jadad score ≥ 3), with funnel plots of primary outcome not suggestive of publication bias.ConclusiontACS appeared to be modestly effective and safe for improving depressive symptoms in patients with MDD, although further studies are warranted.
Antimicrobial activity of a new class of synthetic retinoid antibiotics and comparator agents against ocular staphylococci
Authors: André Camille , Schrank Cassandra L. , Cheng Jaramillo Ana Victoria , Mylonakis Eleftherios , Wuest William M. , Gilmore Michael S. , Kim Wooseong , Bispo Paulo J. M. 
Published: March 2023

ObjectivesAntimicrobial resistance is global pandemic that poses a major threat to vision health as ocular pathogens, especially staphylococcal species, are becoming increasingly resistant to first-line therapies. Here we evaluated the antimicrobial activity of a new class of synthetic retinoids in comparison to currently used antibiotics against clinically relevant ocular staphylococcal isolates.MethodsAntimicrobial susceptibility testing was performed by broth microdilution for 3 novel synthetic retinoids (CD1530, CD437, and a CD437 analogue) and 7 comparator antibiotics, against a collection of 216 clinical isolates.ResultsCD437 MIC50 and MIC90 were 2 µg/mL for Staphylococcus aureus, and 1 µg/mL and 2 µg/mL respectively, for coagulase-negative staphylococci (CoNS). CD1530 (MIC50 = 2 µg/mL for all species) also displayed good activity with an in vitro potency slightly lower (2-fold) for S. aureus (MIC90 = 4 µg/mL) when compared to CD437. A CD437 analogue also demonstrated good in vitro activity (MIC50 = 2 µg/mL for all species) and potency (MIC90 = 2 µg/mL for MRSA and 4 µg/mL for MSSA and CoNS). In vitro potencies were similar or higher than that of comparator agents, and were not impacted by multidrug resistance phenotypes.ConclusionOur results demonstrate that synthetic retinoids display potent in vitro activity against ocular staphylococcal species, including multidrug-resistant isolates.
A Survey on the Hausdorff Dimension of Intersections
Authors: Mattila Pertti 
Published: March 2023

Let A and B be Borel subsets of the Euclidean n-space with dimA+dimB>n. This is a survey on the following question: what can we say about the Hausdorff dimension of the intersections A∩(g(B)+z) for generic orthogonal transformations g and translations by z?
Der Carbon Intensity Indicator (CII) in der Schifffahrt
Authors: Hilgenfeld Carsten , Gerdes Rebecca , Loest Steffen , Raza Raghib 
Published: March 2023

Der sechste Lagebericht des zwischenstaatlichen Ausschusses für Klimaänderungen (IPCC, Intergovernmental Panel on Climate Change) aus dem Jahr 2021 hat die Welt in hohem Maße sensibilisiert. Die IPCC-Prognosen besagen, dass die globale Temperatur um bis zu 5 Grad Celsius steigen könnte (vgl. IPCC 2021:13). Dies ist ein Extremszenario und daher unwahrscheinlich, aber eben auch nicht ausgeschlossen.
An dieser Situation ist die kommerzielle Schifffahrt maßgeblich beteiligt. Laut der 4. IMO Greenhouse Gas Study haben Schiffe mit einer Bruttoraumzahl über 100 weltweit im Jahr 2018 rund 1.076 Millionen Tonnen Kohlenstoffdioxid ausgestoßen (vgl. IMO 2021). Das entspricht fast 3 % der globalen CO2-Emissionen und einem Anstieg von fast 10 % im Vergleich zu 2012 (vgl. Europäische Kommission 2022; IMO 2019a). Die IMO setzt sich dafür ein, diesem unkontrollierten Emissionswachstum Einhalt zu gebieten und den Schaden zu begrenzen.
Daher hat sich die IMO das Ziel gesetzt, die CO2-Emissionen bis 2030 um 40 % und bis 2050 sogar um 70 % gegenüber dem Stand von 2008 zu senken (vgl. IMO 2019b). Um dieses Ziel zu erreichen, wurden unter anderem Mechanismen wie der EEDI (Energy Efficiency Design Index), der EEXI (Energy Efficiency Existing Ship Index), und jetzt der Kohlenstoffintensitätsindikator (Carbon Intensity Indicator, CII) eingeführt.
L’indemnisation des proches des victimes directes d’actes de terrorisme par le FGTI
Authors: Gibard Justine 
Published: March 2023

Le Fonds de garantie des victimes des actes de terrorisme et d’autres infractions (« FGTI ») a été créé en 1986 afin de réparer intégralement les dommages résultant d’une atteinte à la personne des victimes d’actes de terrorisme. À l’occasion de trois arrêts rendus le 27 octobre 2022, la Cour de cassation a précisé que les proches d’une victime directe d’acte de terrorisme ayant survécu peuvent être indemnisés par ce fonds de garantie au titre de leur préjudice personnel.
اتجاهات معلمي ومعلمات مدارس قضاء المقدادية نحو استعمال الدراما في التعليم الابتدائي
Authors: م. د. ناطق سعيد الحلاق  
Published: March 2023

هدفت الدراسة إلى التعرف معلمي ومعلمات مدارس قضاء المقدادية نحو استعمال الدراما في التعليم للمتغيرات (الجنس، المؤهل العلمي، الخبرة) على تلك الاتجاهات.
وتم اختيار عينة من معلمي ومعلمات قضاء المقدادية بالطريقة القصدية تكونت من (282) معلماً ومعلمة من مجموع الدراسة.
صمم الباحث استبانة عرضها على المحكمين من ذوي الخبر والاختصاص، وتم حسب معامل الثبات فبغ (81%) وبعد تطبيق الدراسة وجمع المعلومات تم معالجتها احصائياً منها (التكرارات، النسبة المئوية، المتوسط الحسابي، الانحراف المعياري، واختبارها (t- test) وتحليل التباين الاحادي، وقد توصلت الدراسة إلى ما يلي:

كانت اتجاهات معلمي ومعلمات مدارس قضاء المقدادية نحو استعمال الدراما ايجابية.
اظهرت نتائج الدراسة أن مجال إدراك المعلم لأثر الدراما في أساليب التدريس كان في الترتيب الاول حيث بلغ نسبته (84,6%).
أشارت نتائج الدراسة الى وجود فروق ذات دلالة احصائية عند مستوى (0,05%) في اتجاهات معلمي ومعلمات مدارس قضاء المقدادية تعزى لمتغير الخبره.
أشارت نتائج الدراسة إلى وجود فروق ذات دلالة احصائية عند مستوى (0,05%) في اتجاهات معلمي ومعلمات مدارس قضاء المقدادية تعزى لمتغير الجنس والمؤهل العلمي.

وبناءً على ذلك توصلت هذه الدراسة من نتائج منها التوصيات والمقترحات منها:

توفير أماكن خاصة في المدارس لاستعمالها لغرض تدريب التلاميذ على الدراما التعليمية.
عقد دورات تدريبيه على اهمية الدراما وطريقة استعمالها في العملية التعليمية.
مفاتحة قسم المناهج في وزارة التربية والتعليم العمل على مسرح المناهج.
الصلابة النفسية وعلاقتها بالمعتقدات الصحية التعويضية لدى طلبة الجامعة
Authors: م.د عماد عبد الامير نصيف  
Published: March 2023

هدف البحث الحالي إلى قياس المتغيرين الاثنين (الصلابة النفسية ، والمعتقدات الصحية التعويضية) لدى طلبة جامعة القادسية ، والموازنة في المتغيرين الاثنين (الصلابة النفسية ، والمعتقدات الصحية التعويضية) على وفق متغير النوع (ذكور، اناث) والتخصص (علمي ،انساني) لدى طلبة جامعة القادسية بالإضافة إلى التعرف على طبيعة العلاقة الارتباطية بين (الصلابة النفسية ، والمعتقدات الصحية التعويضية) لدى طلبة جامعة القادسية، ولتحقيق أهداف البحث تم اعتماد أداتان، الاولى لقياس الصلابة النفسية، والثانية للمعتقدات الصحية التعويضية لدى طلبة الجامعة، تتوفر فيهما الخصائص السيكومترية الواجب توافرها في بناء المقاييس النفسية كالصدق والثبات والقدرة على التمييز. حيث طبقت هذه الأدوات على عينة قوامها (100) طالب وطالبة تم اختيارها بطريقة عشوائية من طلبة جامعة القادسية ومن الاختصاصات العلمية والإنسانية.
وبعد معالجة البيانات إحصائيا ، أتضح أن الطلبة يتمتعون بصلابة نفسية، وظهر أن طلبة الجامعة لديهم معتقدات صحية تعويضية ، كذلك ظهر انه لا توجد فروق دالة إحصائياً على وفق متغير النوع (ذكور، إناث) في كلًّ من: (الصلابة النفسية ، والمعتقدات الصحية التعويضية) لدى طلبة الجامعة، كما تبين وجود فروق دالة احصائياً في كل من(الصلابة النفسية ، والمعتقدات الصحية التعويضية) على وفق متغير التخصص (علمي، انساني) ولصالح التخصص العلمي وفي كلا المتغيرين، كذلك ظهران هناك علاقة ارتباطية ايجابية بين (الصلابة النفسية ، والمعتقدات الصحية التعويضية). وقد تقدم الباحث بعدد من التوصيات والمقترحات.
Dysfunctional Families: A Study in Flannery O’Connor’s “A Good Man is hard to Find” and “Good Country People”
Authors: Jinan Abdulla Shafiq  
Published: March 2023

Flannery O’Connor is one of the great short stories writers of the twentieth century. She wrote about southern life. She reflects a theme that became well-known in most of the modern works, which is the dysfunctional family. It is the sense of vanity and disobedience that leads to dysfunctional families that became a modern age phenomena.
In “A Good Man is Hard to Find” one can find the self- reliant individualو the Baily, his kids and the grandmother. No one seems to pay any attention to the grandmother’s fears or suggestions, it is only her cat that gives her the sense she is not alone. In ‘Good Country People’ O’Connor’s other short story that deals with a prideful individual ‘Joy Hopefull’, with her fits of rage, she reveals an image of dysfunctional family. Challenging her mother who treats her as still a young child, Joy changes her name to Hulga. Breaking with her mother and the traditions, Hulga became an easy prey to a deceiving Bible salesman.