bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression and clinical significance of NRLP1 in patients with ST-segment elevation myocardial infarction combined with malignant ventricular arrhythmia
Authors: Xie Sixin , Jiang Huiqiong , Gao Zilin , Lin Yongjun , Hong Najiao 
Published: May 2023

Objective: To investigate the clinical effects of NRLP1 expression in patients with ST-segment elevation myocardial infarction (STEMI) combined with arrhythmia.
Methods: We enrolled 231 patients with STEMI in the first hospital of Guangzhou affiliated to Fujian Medical University from January 2019 to December 2020 to the observational group and 230 healthy individuals as the control group. We divided patients with STEMI into a malignant ventricular arrhythmia (MVA) group (n=36) and non-MVA(NMVA) group (n=195) depending on whether the individuals had experienced an episode of MVA within 48 hours after PCI. We recorded general variables such as age, gender, history of smoking, hypertension, of diabetes, hyperlipidemia, left ventricular ejection fraction (LVEF), Gensini score, and mortality. Moreover, we determined NLRP1, IL-1β, TNF-α, high-sensitivity C-reactive protein (hs-CRP), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), cardiac troponin-1 (cTnI), and creatine kinase isoenzyme (CK-MB) in peripheral blood by ELISA.
Results: We found significant differences in LVEF, Gensini scores, smoking history, and mortality between the MVA and NMVA groups. The mean NLRP1 expression was highest in the MVA group, which was positively correlated with the levels of IL-1β, TNF-α, hs-CRP, NT-pro-BNP, cTnI and CK-MB. The expression of NLRP1 was associated with the smoking history, the LVEF value, the Gensini score, the MVA incidence and the mortality. Patients with higher NLRP1 expression levels had a higher MACE incidence and worse overall survivals within one year.
Conclusion: The NLRP1 pathway is associated with the presence of arrhythmias after PCI treatments, and the NLRP1 expression level may be useful as a predictor of arrhythmia in patients with STEMI.
doi: https://doi.org/10.12669/pjms.39.4.7324
How to cite this: Xie S, Jiang H, Gao Z, Lin Y, Hong N. Expression and clinical significance of NRLP1 in patients with ST-segment elevation myocardial infarction combined with malignant ventricular arrhythmia. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7324
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The proliferation and angiogenesis in hemangioma-derived endothelial cells is affected by STC2 medicated VEGFR2/Akt/eNOS pathway
Authors: Ren Shanshan , Yang Yuchang 
Published: May 2023

Objective: Stanniocalcin-2 (STC2), a secreted glycoprotein that is involved in the regulation of angiogenesis, was proposed as one of the mechanisms of neovascularization in hemangioma (HA). We aimed to investigate the effect of STC2 on proliferation and angiogenesis in hemangioma-derived endothelial cells.
Methods: The hemangioma samples from HA patients with the median age of six months were surgically collected in the Affiliated Hospital of Weifang Medical University from October 2019 to June 2021, and divided into normal skin tissues (n=10), involuting-phase HAs (n=10) and proliferating-phase HAs (n=10) according to the Mulliken classification. The expression of STC2 was detected in involuting-phase HAs and proliferating-phase HAs. Hemangioma endothelial cells (HemEC) were transfected with small interfering RNA (siRNA) specific for STC2, and cell survival and tube formation were analyzed.
Results: STC2 expression in proliferating-phase HAs was markedly higher than in the normal skin tissues and involving-phase HAs. Similarly, STC2 expression was higher in HemEC compared to the control human umbilical vein endothelial cells (HUVEC). Knockdown of STC2 slowed the proliferation of HemEC and decreased the expression of proliferating cell nuclear antigen (PCNA) in HemEC. Moreover, knockdown of STC2 in HemEC inhibited vascular endothelial cell angiogenesis and regulated the expression and phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2). Mechanistically, STC2 knockdown attenuated the activation of Akt/eNOS signaling, which was abolished by insulin growth factor-1 (IGF-1), the activator of Akt signaling, accompanying by increased proliferation and tube formation of HemEC.
Conclusion: Inhibition of STC2 suppresses HemEC proliferation and angiogenesis by VEGFR2/Akt/eNOS pathway, which warrants further development of STC2-based strategies for HA treatment.
doi: https://doi.org/10.12669/pjms.39.4.7384
How to cite this: Ren S, Yang Y. The proliferation and angiogenesis in hemangioma-derived endothelial cells is affected by STC2 medicated VEGFR2/Akt/eNOS pathway. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7384
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Effectiveness of deep brain stimulation in Parkinson’s disease treatment with Single-center experience in Pakistan
Authors: Kalhoro Aurangzeb , Hashim Abdul Sattar M 
Published: May 2023

Objective: To assess the effectiveness and accuracy of deep brain stimulation in Parkinsonian Disease (PD).
Methods: This study was a descriptive prospective study, and patients were treated at Neurospinal and Cancer Care Institute Karachi, from February 1, 2016, to June 30, 2020. We had 21 cases of parkinsonian disease. Inclusion criteria was Idiopathic Parkinson’s disease, marked motor fluctuations against the response to dopaminergic therapy, UPDRS-III scores, which is 30 or higher, with a duration of disease of five years or longer, developing dyskinesia while the exclusion criteria was patient with known comorbid or active psychiatric disease
Results: Mean age of patient was 64 years. The standard deviation was 1.11697. The male patients’ mean, median and mode had a standard deviation of 0.3. For the duration of disease, the mean was 1.4, the median 1 (5-6 years) and mode one. The standard deviation was 0.51177. The primary symptoms’ mean was 2.2857, the median was 2.0, and the mode was two (tremor). The mean on medication (age) was 2 (45-49), and the median and mode were the same.
Conclusion: Deep brain stimulation (DBS) is an effective treatment option for a carefully selected patient. DBS improves tremors, dyskinesias, rigidity, motor fluctuations and bradykinesia. DBS is unlikely to benefit Autonomic dysfunction, cognitive disorders, hypophonia, and postural instability. Although it is an expensive treatment compared to lesioning or gamma knife, it is reversible.
doi: https://doi.org/10.12669/pjms.39.4.7680
How to cite this: Kalhoro A, Hashim ASM. Effectiveness of deep brain stimulation in Parkinson’s disease treatment with Single-center experience in Pakistan. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.7680
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Knowledge, attitudes, and behaviour of college students in disposing used masks during the COVID-19 pandemic in DKI Jakarta Province
Authors: Inovasanti Avicenna , Susanna Dewi , Poddar Sandeep , Hermawati Ema , Kusuma Aria 
Published: May 2023

Background: The COVID-19 pandemic has increased the need for and production of masks. This creates a problem, namely the generation of mask waste which ends up in the environment without being managed. This research was conducted to determine the relationship between knowledge, attitudes, and sociodemographic factors with college student behaviours in managing household mask waste in Daerah Khusus Ibukota (DKI) Jakarta Province. Methods: This study used a quantitative approach and cross-sectional study design. Data collection was carried out using an online questionnaire consisting of the respondents' sociodemographic, knowledge, attitudes, and behaviours. Results: The majority of students had high knowledge (63.3%), positive attitudes (52.5%), and good behaviours (50.6%). Statistically, there was a significant relationship between knowledge and behaviours (p-value = 0.022), but there was no significant relationship between attitudes and behaviours (p-value = 0.269). In addition, the sociodemographic factor variables showed a significant relationship between place of residence and behaviours (p-value = 0.008). However, there was no significant relationship between age, gender, education, and study program groups and behaviours (p value> 0.05). Multivariate analysis showed that living with family was a dominant factor for bad behaviours (OR 1.664, 95% CI=1.124-2.464), and the second risk factor was the low level of knowledge has a significant relationship with the behaviours of mask waste management at home (OR=1.559, 95% CI=1.044-2.330). Conclusions: Students who live alone show better behaviour compared to students who live with their families. The place of residence variable has the greatest influence on the behaviour of mask waste management at the household, followed by the knowledge variable.
Exercises on a balancе cushion to influence of lumbar vertebral syndrome
Authors: Zlatkova Krasimira , Zlatkov Yuliyan 
Published: May 2023

Background: The pain in the lumbar region is common. One of the causes of low back pain is lumbar vertebral syndrome. There is a wide range of options for treating low back pain. The purpose of the study is to describe exercises on a balance cushion to influence the pain in lumbar vertebral syndrome and to track the effect of their application. Methods: We studied 20 participants with low back pain. We applied the following tests to the patients: visual analogue scale, Schober test, measurement of lateral flexion and Straight leg raise test. The methodology includes exercises on a balance cushion. We performed manual manipulation techniques on each patient by treating trigger points in the lower back and buttocks once a week. Results: We achieved an improvement in the studied indicators after the applied therapy, which was expressed in a reduction of pain and restoration of normal mobility in the lumbar region. Conclusions: The application of exercises on a balance cushion allows in a short time to affect the pain and mobility in the lumbar spine to fully perform their work and professional activities.
SEPARATE ASPECTS OF THE CONTENT AND CONCLUSION OF CONTRACTS FOR THE PERFORMANCE OF SURVEYING WORKS
Authors: Berezina Yuliya P. 
Published: May 2023

Contracts of the performance of surveying works (provision of services) are concluded by subsoil users in the process of mining. The contract under study is a civil law nature, despite the fact that the results of contract work and services rendered are used in the public sphere. The quality of surveying work performance affects the safety of mining operations and the financial result of the subsoil user-customer.
Based on the analysis of the practice of concluding contracts and their content, the author comes to the conclusion that it is necessary to fix the requirements for technical conditions and regulations for the performance of surveying works (services) by the contractor (performer) as essential terms of the contract. The article is not only of scientific interest, but also has practical significance for the participants in contractual and claim work.
LEGAL REGULATION OF MEASURES OF STATE SUPPORT IN THE PROCESS OF THE IMPLEMENTATION OF NORTHERN DELIVERY
Authors: Goncharuk, Galina V. 
Published: May 2023

The relevance of the issue investigated in the article lies in the need to provide state support measures for the implementation of northern delivery measures to the territory of the Arctic zone of the Russian Federation in order to ensure the preservation of human capital here.
The purpose of the study is to substantiate the need for state participation in the process of northern delivery and to propose a number of changes to the legislation of the Russian Federation, based on the analysis of the legal regulation of measures of state financial support for the implementation of the northern delivery. On the example of the Republic of Sakha (Yakutia), the study presents a general characteristic of the measures of state financial support for the activities of the northern delivery and their regulatory and legal regulation, an analysis of the actual financial assistance provided to a number of organizations participating in the delivery.
In the final part of the article, the author comes to the conclusion about the exclusive role of the state in financing the processes of northern delivery to the territory of the Arctic zone of the Russian Federation, proposes to make a number of changes to the budget legislation of Russia.
Utility Preference Robust Optimization with Moment-Type Information Structure
Authors: Guo Shaoyan , Xu Huifu , Zhang Sainan 
Published: May 2023

Utility Preference Robust Optimization with Moment-Type Information Structure In some decision-making problems, information on the true utility function of the decision maker may be incomplete, which may bring potential modeling risk. In “Utility Preference Robust Optimization with Moment-Type Information Structure,” Guo, Xu, and Zhang propose a maximin utility preference robust optimization model where information about the DM’s preference is constructed by moment-type conditions. The authors propose a piecewise linear approximation approach to tackle the maximin problem, reformulate the approximate problem as a single mixed integer linear program, and derive error bounds for the approximate ambiguity set, the optimal value, and the optimal solutions. To examine the performance of the model and the computational schemes, they carry out extensive numerical tests and demonstrate the effectiveness of the model and efficiency of the computational methods.
Determination of stress waves and their effect on the damage extension induced by surface defects of KDP crystals under intense laser irradiation
Authors: Ding Wenyu , Zhao Linjie , Chen Mingjun , Cheng Jian , Chen Guang , Lei Hongqin , Liu Zhichao , Geng Feng , Wang Shengfei , Xu Qiao 
Published: May 2023

The residual crack defects on the surface of potassium dihydrogen phosphate (KDP) crystals are the bottleneck that limits the improvement of laser damage resistance in the application of high-power laser devices. The multiple stress waves introduced by these residual surface lateral cracks on crystals under laser irradiation are the main inducement for damage extension and reduction of laser damage resistance. However, the coupling of these stress waves complicates their propagation in the crystal, and the interaction mechanism between each stress wave and laser damage has not been quantitatively characterized. Herein, a laser damage dynamic model for surface lateral cracks is constructed to reproduce the dynamic behaviors of the evolution of micro-defects to sub-millimeter damage pits under laser irradiation. Combined with the time-resolved pump and probe technique, the distribution of stress waves induced by lateral cracks was detected in situ to determine the type of stress waves. Then, the initiation and extension of laser damage were analyzed quantitatively to establish the correlations between different stress waves and damage extension. It is found that the longitudinal, shear, and Rayleigh waves induced by lateral cracks lead to large crush zones on the surface of KDP crystals, as well as butterfly-like damage sites accompanied by a large number of cracks at the bottom in the longitudinal section. The scale of the damage site can reach up to approximately 150 µm for lateral crack defects with large surface widths. This study ultimately reveals the physical mechanism of damage evolution induced by lateral cracks, providing effective guidance for developing control standards of surface crack defects during optical ultra-precision machining processes. This is of great significance for the improvement of laser damage resistance of KDP crystals in high-power laser systems.
Can Ivermectin kill Sarcoptes scabiei during the molting process?
Authors: Feng Shenrui , Shi Minmin , Yin Zhijuan , Di Wenda , Guillot Jacques , Fang Fang 
Published: May 2023

BackgroundSarcoptes scabieiis a permanent obligate ectoparasite that lives and reproduces in the epidermis of humans and other mammals worldwide. There is a lack of information on the molting process ofSarcoptes scabiei. Ivermectin is widely used to treatSarcoptesinfection in humans and animals, while the survival of moltingSarcoptesmites in the presence of ivermectin is unknown. The aim of the present study is to investigate the molting process ofSarcoptesmites and assess the activity of ivermectin during the molting process ofSarcoptesmites.Methodology/Principal findingsmoltingSarcoptesmites were incubated at 35°C and 80% relative humidity and observed hourly until complete molt. Of the 192 molting mites recorded, the longest molt periods for larvae and nymphs were 23 and 30 h, respectively. The activity of ivermectin on moltingSarcoptesmites was also assessed using two concentrations of the drug (0.1 and 0.05 mg/ml). The exposure time for molting mites was determined by 100% mortality of female mites exposed to the solution of ivermectin. While all female mites were killed after exposure to 0.1 mg/ml ivermectin for 2 h and and 0.05 mg/ml for 7 h, 32% and 36% of molting mites survived and successfully molted, respectively.Conclusions/significanceThe present study demonstrated that moltingSarcoptesmites are less susceptible to ivermectin than active mites. As a consequence, mites may survive after two doses of ivermectin given 7 days apart due not only to hatching eggs but also to the resistance of mites during their molting process. Our results provide insight into the optimal therapeutic regimens for scabies and highlight the need for further research on the molting process ofSarcoptesmites.
Evaluation of 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic: A cross-sectional study and trend analysis involving 86,772 samples
Authors: Arayıcı Mehmet Emin , Korkut-Uysal Sila Ovgu , Leblebici Asim , Akcali Zeynep , Edizer Deniz Tuna , Kabul Seher , Cimrin Dilek , Ellidokuz Ender Berat 
Published: May 2023

Background
The aim of this paper was to evaluate the change in 25-hidroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic.

Methods
In this retrospective, cross-sectional and methodological study included 86,772 patients (18–75 years) samples who were admitted to the Izmir Dokuz Eylul University Hospital (latitude and longitude (Turkey): 27 E 09; 38 N 25, respectively) for various reasons and whose 25(OH)D levels were measured in the biochemistry unit between 2019–2020 and 2020–2021 (before and during the COVID-19 outbreak). A time series analysis of monthly averages for 25(OH)D was performed. For the purpose of seasonal study, the mean levels of 25(OH)D are grouped by years. Data were modeled in terms of 25(OH)D levels using the MATLAB Curve Fitting Toolbox.

Results
There was no significant difference between the sexes according to 25(OH)D levels (p>0.05). 25(OH)D levels were significantly higher in the summer months and lower in the winter months (p<0.001). When comparing the spring months, 25(OH)D levels in 2020 (18 ± 10) were found to be significantly lower than in 2019 (22 ± 12) (p<0.001); on the contrary, when examined based on the summer, autumn, and winter months, it was determined that 25(OH)D levels increased in 2020 (summer: 25 ± 13, autumn: 25 ± 14, and winter: 19 ± 10) compared to 2019 (summer: 23 ± 11, autumn: 22 ± 10, and winter: 19 ± 11) (p<0.001). In the estimates curve obtained with an error margin of 11% in the time series analysis, it was estimated that the 25(OH)D averages after the pandemic would be similar to those before the pandemic.

Conclusions
Restrictions, partial or complete closures, and curfews can significantly affect individuals’ 25(OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support our results.
The effect of body mass index reduction on intraocular pressure in a large prospective cohort of apparently healthy individuals in Israel
Authors: Coster Dan , Rafie Ariel , Savion-Gaiger Noam , Rachmiel Rony , Kurtz Shimon , Berliner Shlomo , Shapira Itzhak , Zeltser David , Rogowski Ori , Shenhar-Tsarfaty Shani , Waisbourd Michael 
Published: May 2023

Purpose
To investigate the effect of change in body mass index (BMI) on intraocular pressure (IOP) in a large cohort of apparently healthy volunteers who underwent an annual comprehensive screening examinations.

Methods
This study included individuals who were enrolled in the Tel Aviv Medical Center Inflammation Survey (TAMCIS) and had IOP and BMI measurements at their baseline and follow up visits. Relationships between BMI and IOP and the effect of change in BMI on IOP were investigated.

Results
A total of 7,782 individuals had at least one IOP measurement at their baseline visit, and 2,985 individuals had ≥2 visits recorded. The mean (SD) IOP (right eye) was 14.6 (2.5) mm Hg and mean (SD) BMI was 26.4 (4.1) kg/m2. IOP positively correlated with BMI levels (r = 0.16, p<0.0001). For individuals with morbid obesity (BMI≥35 kg/m2) and ≥2 visits, a change in BMI between the baseline and first follow-up visits correlated positively with a change in the IOP (r = 0.23, p = 0.029). Subgroup analysis of subjects who had a reduction of at least 2 BMI units showed a stronger positive correlation between change in BMI and change in IOP (r = 0.29, p<0.0001). For this subgroup, a reduction of 2.86 kg/m2 of BMI was associated with a reduction of 1 mm Hg in IOP.

Conclusions
BMI loss correlated with reduction in IOP, and this correlation was more pronounced among morbidly obese individuals.
The characteristics and survival of second primary lung cancer after Hodgkin’s lymphoma: A comparison with first primary lung cancer using the SEER database
Authors: Lin Ling , Wang Daquan , Chen Haizhu 
Published: May 2023

Objective
The study aimed to compare the characteristics and prognosis between patients with second primary lung cancer following Hodgkin’s lymphoma and those with primary lung cancer.

Materials and methods
Using the SEER 18 database, the characteristics and prognosis were compared between the second primary non-small cell lung cancer following Hodgkin’s lymphoma (HL-NSCLC) (n = 466) and the first primary non-small cell lung cancer (n = 469,851)(NSCLC-1), as well as between the second primary small cell lung cancer following Hodgkin’s lymphoma (n = 93) (HL-SCLC) and the first primary small cell lung cancer (n = 94,168) (SCLC-1). Comparisons of categorical variables were performed using Chi-square or Fisher’s test. Continuous variables were compared using the Mann-Whitney U test. Overall survival (OS) was estimated using the Kaplan-Meier method, and the difference between groups was analyzed by log-rank test.

Results
HL-NSCLC group had more males than NSCLC-1 group, and the median age of HL-NSCLC group was younger than that of NSCLC-1 group. Patients with HL-NSCLC showed inferior OS than those with NSCLC-1 (median: 10 months vs. 11 months, P = 0.006). Both HL-SCLC and SCLC-1 groups had poor prognosis, with median OS of 7 months (P = 0.4). The 3-year cumulative risks of death from any cause for patients with the latencies from HL to NSCLC of 0 to 5 years, >5 to 10 years, >10 to 15 years, >15 to 20 years, and>20 years were 71.8%, 82.6%, 86.8%, 85.7% and 78.5%, respectively(P = 0.020).

Conclusion
HL-NSCLC patients had worse prognosis than NSCLC-1 patients, while HL-SCLC patients shared similar characteristics and survival with SCLC-1 patients.