bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of K.H Muhammad Burkan Saleh in The Development of Islam in Kerinci
Authors: Satria Oga 
Published: July 2023

The process of Islamic development in each region was heavily influenced by scholars from outside the region and local residents within the area. As time goes by, the role of the clergy in the process of Islamic development becomes increasingly important because it is accompanied by various problems and needs of the people they face. Therefore, it is important to confirm their contribution from time to time as K.H Muhammad Berkan Saleh has done. This survey uses a qualitative research method. While the approach used in this study is historical in nature which allows us to see the events that surrounded K.H Muhammad Berkan Saleh throughout his lifetime. In addition, this study uses a philological approach to the works written by K.H Muhammad Berkan Saleh.

Proses perkembangan Islam di setiap daerah banyak dipengaruhi oleh para ulama baik dari luar daerah maupun penduduk lokal di dalam daerah tersebut. Seiring berjalannya waktu, peran ulama dalam proses pembangunan Islam menjadi semakin penting karena dibarengi dengan berbagai masalah dan kebutuhan umat yang dihadapinya. Oleh karena itu, penting untuk mengkonfirmasi kontribusi mereka dari waktu ke waktu sebagaimana yang dilakukan oleh K.H Muhammad Berkan Saleh. Survei ini menggunakan metode survei kualitatif. Sedangkan pendekatan yang digunakan dalam penelitian ini bersifat historis yang memungkinkan kita untuk melihat peristiwa-peristiwa yang melingkupi K.H. Muhammad Berkan Saleh semasa hidupnya. Selain itu, penelitian ini menggunakan pendekatan filologi terhadap karya-karya yang ditulis oleh K.H. Muhammad Berkan Saleh.
PROGRESS ON THE BREAKDOWN VOLTAGES AND LEAKAGE CURRENTS ANALYSIS OF MULLITE PRODUCED FROM KAOLIN
Authors: Aliyu A. , Imam R. I. , Galadima A. I. , Suleiman S. A. 
Published: July 2023

Kaolin is a clay mineral that has found its huge use in electrical insulation. In electrical power industries, mullite insulators plays a vital role during electric power transmission. The transformation of kaolin to mullite via sintering method was carried out by varying the temperature during heating at interval of from to . The mass of the kaolin was observed to have changed during the heating until the complete transformation took place at the temperature of 11500C. The dielectric strength (breakdown voltage) was analysed by sending high input voltage through the samples and measuring the output voltage until breakdown occurred. The input voltage of to was passed through the samples and breakdown occurred at input voltage for almost all the samples. The leakage current was also determined using Ohm’s law. 11500C was found to be the optimum temperature for the transformation of kaolin to mullite. The leakage current value ( )was found to be negligible making mullite a good dielectric material for insulation.
Hubungan Kebiasaan Bermain Gadget dengan Prestasi Belajar pada Anak Usia Sekolah
Authors: Rahmat Sandi  , Sunarti  , Yusrah Taqiyah  
Published: July 2023

ABSTRAK
Perkembangan teknologi dan informasi mengalami kemajuan yang sangat pesat yang ditandai dengan kemajuan pada bidang informasi dan teknologi. teknologi yang berkembang saat ini salah satunya yaitu gadget. Gadget digunakan oleh kalangan muda diantaranya siswa di usia sekolah oleh karenanya gadget juga memiliki nilai dan manfaat tersendiri, khususnya prestasi belajar siswa. maka penelitian ini bertujuan untuk mengetahui hubungan kebiasaan bermain gadget dengan prestasi belajar pada anak usia sekolah di SDN Inpres 3 Kalumbatan Kecamatan Totikum Selatan Kabupaten Banggai Kepulauan. Desain penelitian yang digunakan dalam penelitian ini adalah deskriptif korelasi dengan menggunakan pendekatan Cross Sectional. Adapun penentuan sampel dilakukan dengan teknik simpel Random Sampling dengan besar sampel sebanyak 95 siswa. Uji hubungan dengan menggunakan uji statistik Uji Chi Square (X2) dengan tingkat kemaknaan = 0.05. Hasil penelitian menunjukkan, siswa yang terbiasa menggunakan gadget sebanyak 70,5% dan siswa yang tidak terbiasa menggunakan gadget sebanyak 29,5%. Sedangkan siswa dengan kategori prestasi baik yaitu 36 (37,9%) dan jumlah siswa kategori prestasi kurang sebanyak 24,2%. uji statistik chi-square didapatkan nilai ρ = 0.447 lebih besar dari α= 0.05. Kesimpulan dari penelitian ini yaitu bermain gadget tidak memiliki hubungan yang signifikan dengan prestasi belajar pada anak usia sekolah di SDN Inpres 3 Kalumbatan Kecamatan Totikum Selatan Kabupaten Banggai Kepulauan. Saran dalam penelitian ini diharapkan bahwa gadget dingunakan untuk hal-hal yang bermanfaat bagi prestasi belajar.
Hubungan Perilaku Merokok dengan Prestasi Belajar pada Siswa SMK
Authors: Wiwin Ferdita  , Alwi Muhammad Khidri , Asfar Akbar 
Published: July 2023

Remaja dimasa era globalisasi seperti ini banyak timbulnya pengaruh-pengaruh dari luar yang diantaranya ada yang membawa dampak positif dan dampak negatif. Dalam hal ini seorang remaja berada pada masa coba-coba atau masa dimana remaja selalu ingin tahu dengan apa yang ada di lingkungan sekitar. Pada masa ini remaja berada pada masa labil, yang artinya pada masa ini mereka sangat mudah terpengaruh oleh pergaulan yang berkembang pada saat ini. Pada usia remaja penuh dengan rasa penasaran dan rasa ingin tahu yang tinggi dengan hal-hal yang baru. Untuk lebih jelasnya para remaja saat ini sudah tidak asing lagi dengan adanya pengaruh dan rasa ingin tahu terhadap rokok. Remaja saat ini sudah menyadari bahwa sebenarnya merokok memiliki banyak dampak negatif yang membahayakan kondisi kesehatan tubuh seseorang. Penelitian ini bertujuan untuk mengetahui hubungan perilaku merokok dengan prestasi belajar pada siswa di SMK Negeri 4 Kota Bima. Desain penelitian yang digunakan adalah korelasional kuantitatif non-eksperimen dengan menggunakan teknik pengambilan sampel secara proportional stratified random sampling dengan jumlah sampel 49 siswa. Uji statistik yang digunakan yaitu uji chi-square dengan α 0,05. Hasil penelitian menunjukkan bahwa perilaku merokok ringan yang prestasi belajar baik sebanyak 58,3%, perilaku merokok ringan yang kondisi prestasi belajar kurang baik sebanyak 41,7%, sedangkan perilaku merokok berat dengan prestasi belajar baik sebanyak 27,0%, perilaku merokok berat yang prestasi belajar kurang baik sebanyak 73,0%. Kesimpulan dari penelitian ini bahwa ada hubungan perilaku merokok dengan prestasi belajar dengan nilai p-value 0,048.
Efecto de disrupción endocrina de la genisteína sobre Caenorhabditis elegans
Authors: Mallarino Miranda Liset Paola , Palacio Villalba Belkis de la Candelaria , Arroyo Salgado Bárbara Julia , Tejeda Benítez Lesly Patricia , García Espiñeira María Cecilia 
Published: July 2023

La genisteína es una isoflavona presente en la soya, de alto consumo en la población infantil por su uso como sucedáneo de la leche materna, sin embargo, poco se sabe acerca de los efectos a nivel endocrino. En este trabajo, Caenorhabditis elegans se utilizó como modelo para evaluar el efecto de disrupción endocrina de la genisteína a través de letalidad, crecimiento, reproducción, almacenamiento de lípidos y cambios en la expresión de genes de respuesta al estrés (hsp-3, sod-4 y gpx-4). Los resultados indicaron que, aunque la genisteína no indujo letalidad, sí promovió la reproducción, el aumento de la longitud del cuerpo, el incremento en la expresión de genes relacionados con estrés celular y estrés oxidativo y la acumulación lipídica. En conclusión, la genisteína generó efectos relacionados con el efecto de disrupción endocrina en C. elegans, muy probablemente a través de mecanismos de estrés oxidativo.
Motivos de diferimiento de potenciales donantes de un banco de sangre de Medellín-Colombia, 2012-2018
Authors: Gómez Alvarez Alejandro , Flórez Duque Jenniffer , Cardona Arias Jaiberth Antonio 
Published: July 2023

Introducción: en Colombia no se dispone de investigaciones sobre las causas de diferimiento de potenciales donantes de sangre.
Objetivo: determinar la prevalencia de los motivos de diferimiento de donantes de un banco de sangre en Medellín-Colombia.
Métodos: estudio transversal con 43.002 sujetos en quienes se estimó la prevalencia general de diferimientos y las específicas por sexo y edad. Para cada motivo de diferimiento se estimaron razones de odds crudas y ajustadas mediante modelos de regresión logística.
Resultados: Los principales motivos de diferimiento fueron el riesgo del compañero sexual (25,2%), hemoglobina inadecuada (15,2%) y procedencia de zonas endémicas de malaria o Chagas (8,2%), la menor prevalencia se registró en la exposición o reactividad a infecciones trasmisibles por transfusión. En las mujeres la mayor prevalencia fue baja hemoglobina, reactividad en pruebas inmunohematológicas, riesgo con elementos cortopunzantes y tratamientos contraindicados para donar, y en los hombres fueron las enfermedades de base, reactividad en marcadores de infección del banco y riesgo sexual.
Conclusión: El banco presentó una alta prevalencia de diferimientos por el comportamiento sexual y la hemoglobina, con diferencias estadísticas según la edad y el sexo. Esto constituye una evidencia relevante para mejorar procesos de captación, campañas educativas y acciones de salud pública, prevención y vigilancia epidemiológica de los diferimientos más prevalentes para garantizar un suministro suficiente de sangre.
Survey of the degree of burnout in state hospitals among Durban and Pietermaritzburg anaesthetists in KwaZulu Natal, South Africa.
Authors: Allie Leana , Govender Komalan 
Published: July 2023

Background: The most widely accepted model that defines the syndrome of burnout is Maslach Multidimensional Theory of Burnout. According to the theory burnout has three dimensions: emotional exhaustion (EE), depersonalisation (DP), and reduced personal accomplishment (PA). The primary aim of this study is to describe the degree of burnout experienced by anaesthetists working in the eThekwini Hospital Complex and Pietermaritzburg Metropolitan state hospitals in KwaZulu Natal in South Africa.
Methods: The Maslach Burnout Inventory a well‐tested instrument with high reliability and validity was used as a measure of burnout with three subscales of emotional exhaustion, depersonalisation, and personal accomplishment.
Results: Of the 160 anaesthetic care givers available, 139 completed the questionnaires giving a response rate of 86.8%. Burnout occurred in all participants that is medical officers (general medical doctors with a diploma in anaesthetics), registrars (general medical doctors with a diploma in anaesthetics or residents training and specializing in anaesthesiology) and consultants (specialists anaesthesiologists with a diploma and a fellowship in anaesthesiology). The prevalence of burnout was 17.9%. Of the total number of participants, greater proportion of anaesthetic care givers were female aged 31 to 40 years and that a substantial percentage had 4 to 8 years’ experience in anaesthesiology. The dimensional scores when considered individually showed that 42% of anaesthetists experienced high levels of emotional exhaustion, 38% reported high levels of depersonalisation and the lack of personal achievements was observed in more than 50% of the practising anaesthetists.
Conclusion:. High levels of burnout were noted among anaesthetists in Kwazulu Natal. An association was noted between quality of sleep and emotional exhaustion and depersonalization. This information could be of value to the department of anaesthesiology as they are in position to implement interventions that promote participants well-being. Anaesthesiology practices should evaluate the balance between the demands they place on anaesthetic care providers and the resources provided to sustain an engaged, productive, and satisfied anaesthetic workforce. If the multiple stressors that lead to burnout are not addressed the department of anaesthesiology will be plagued by burnout.
Reporte de caso: carcinoma metaplásico de mama con componente epitelial escamoso puro y mutación de PIK3CA
Authors: León Crespo Karen Vanessa , Coronel Montero Jorge Sebastián , León Crespo Kevin Sebastián 
Published: July 2023

Introducción. El carcinoma metaplásico de mama con componente epitelial escamoso puro corresponde a un tumor de mama muy raro con una prevalencia entre el 0,06% y 0,2%. Existen una cantidad limitada de reportes de caso sobre esta enfermedad, sus características moleculares están mal definidas y la base subyacente de la heterogeneidad histológica sigue siendo incierta. Objetivo. Describir el caso de una paciente femenina de 67 años diagnosticada con carcinoma metaplásico de mama con componente epitelial escamoso puro y mutación del gen PIK3CA, analizar las características clínicas, patrones histológicos y explorar el tratamiento en esta neoplasia. Metodología. La metodología usada fue un reporte de caso, la información recopilada fue mediante el análisis de la historia clínica de la paciente con previa autorización por medio del consentimiento informado. Resultados. Paciente femenina de 67 años detecta masa palpable en la mama derecha durante autoexploración. Se le realizan exámenes complementarios para valoración y se determina carcinoma metaplásico de mama con componente epitelial escamoso puro con alteración del gen PIK3CA. Actualmente, la paciente ha concluido su terapia adyuvante y se encuentra en control mediante estudio de imagen. Conclusión. El carcinoma metaplásico de mama con componente epitelial escamoso puro enfermedad representa una entidad poco común y agresiva que precisa de un diagnóstico preciso y un tratamiento adecuado. Conocer las alteraciones genéticas pueden ayudar al tratamiento y a la respuesta de este. Área de estudio general: Medicina. Área de estudio específica: Oncología, Patología.
Diseño y manufactura de un block mono cilindro para un motor de 150cc con una aleación Al 7075
Authors: Bravo Morocho Victor David , Abarca Pérez Edison Patricio , Sánchez Carrión Edgar Fabian 
Published: July 2023

Introducción: La manufactura asistida por computadora (CAM), y los procesos de fundición de aluminio, cumplen un papel fundamental en el desarrollo de partes y piezas automotrices con un alto grado de precisión, disminuyendo costos y tiempos. Objetivo: Manufacturar un block de motor mono cilindro de 150 cc, empleando como materia prima aluminio 7075, a partir de un proceso de fundición de tipo “galletas” obtenidas en un software CAD, luego impresas en una impresora 3D hasta obtener los moldes machos en arena de sílice combinada con silicato de sodio como aglutinante endurecedor y de conformado. Metodología: Revisión bibliográfica de procesos de fundición de aleaciones de aluminio, ingeniería inversa, impresión 3D, proceso de fundición por el método de “galleta”. Resultados: Se vertió aluminio líquido en el molde a una temperatura promedio de 850°C combinado con, zinc (5.1-6.1%), magnesio (2.1-2.9%), cobre (1.2-2%), y silicio, hierro, manganeso, cromo y titanio en mínimas proporciones. Una vez enfriado el prototipo se desmoldo y se mecanizó en un centro de mecanizado de 4 ejes y finalmente se insertó la camisa a presión hasta obtener el block terminado. Conclusiones: Se obtuvo un prototipo de block motor mono cilindro de 100 cc. completamente funcional. Área de estudio general: Ingeniería. Área de estudio especifica: Procesos de fundición.
Thermus thermophilus Argonaute-based signal amplifier for highly sensitive and specific microRNA detection
Authors: Wang Ziqi , Wang Zitong , Zhang Fan , Wu Lingyi 
Published: July 2023

The prokaryote-derived gene defense system as a new generation of nucleic acid detection tool exhibits impressive performance in the field of molecular diagnosis. Prokaryotic Argonaute (Ago) is a CRISPR-associated protein that is guided by a short DNA (gDNA) and then efficiently cleaves gDNA-complementary nucleic acids and presents unique characteristics that are different from the CRISPR/Cas system. However, the application of Ago in biosensing is still relatively scarce, and many properties of Ago need to be further clarified. In this study, we aim to systematically explore the properties of Thermus thermophilus Argonaute (TtAgo), including the dependence of TtAgo activity on guide DNA (gDNA) length, substrates’ length, and the position of gDNA complementary region on the substrate. Based on these properties, we constructed an exonuclease III-assisted target-recycled amplification system (exoAgo) for sensitive miRNA detection. The result showed that exoAgo can be used for miRNA profiling with a detection limit of 12.2 pM and single-base-resolution and keep good performance for the detection of complex samples, which indicates that Ago has great application potential in the detection of nucleic acids. In conclusion, this study will provide guidance for further development and utilization of Ago in the field of biosensing.
Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update
Authors: Xu An-ran , Jin Qiuyu , Shen Zhisheng , Zhang Jiaqi , Fu Qiang 
Published: July 2023

BackgroundTriglyceride-glucose (TyG) index has been reported to be associated with various cardiovascular diseases in recent years. However, the conclusive association between the TyG index and hypertension was not established in the last meta-analysis. Furthermore, it remains unclear whether a linear relationship exists between these two variables.MethodsWe conducted a comprehensive search of the CNKI, VIP, WanFang Data, CBM, PubMed, EMbase, Web of Science, and The Cochrane Library databases up until May 10, 2023, to identify relevant studies conducted in China. We used Stata version 17.0 and Rstudio version 4.2.1 to analyze the data and assess the association between the TyG index and the risk of hypertension, as well as the dose-response relationship between these two variables. We will select either a random-effects model or a fixed-effects model based on the results of the heterogeneity tests and report 95% confidence intervals accordingly.ResultsIn the end, our analysis encompassed 22 studies involving a total of 668,486 participants, comprising 12 cross-sectional studies and 10 cohort studies. Meta-analysis results showed: Analysis of data from China revealed that an elevated TyG index was associated with a higher risk of developing hypertension, as indicated by an OR/HR of 1.36 [95%CI (1.28–1.45) I2 = 69.0% P &lt; 0.001]. Through meta-regression analysis of multiple covariates, we found that study type, study region, sample size, database source, and study quality score, the above five variables were able to explain 63.0% of the total heterogeneity. The results of the dose-response Meta-analysis showed: The TyG index has a linear relationship with the risk of developing hypertension, as indicated by non-significant coefficients of higher-order terms in the nonlinear model (P &gt; 0.05). The linear trend analysis showed that for every one-unit increase in the TyG index, the risk of developing hypertension increased by 1.5 times [1.532 95%CI (1.294, 1.813) P &lt; 0.001]. However, this result is influenced by the number of studies included in the dose-response analysis and requires further corroboration.ConclusionIn the Chinese region, there was an independent association between TyG index and the risk of developing hypertension, with a linear trend. However, the results of the linear trend need to be corrected by the more number of related studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425836.
Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer
Authors: Xu Yinghua , Chen Xionghuan , Liu Nan , Chu Zhong , Wang Qiang 
Published: July 2023

BackgroundSingle-cell sequencing technology has become an indispensable tool in tumor mechanism and heterogeneity studies. Pancreatic adenocarcinoma (PAAD) lacks early specific symptoms, and comprehensive bioinformatics analysis for PAAD contributes to the developmental mechanisms.MethodsWe performed dimensionality reduction analysis on the single-cell sequencing data GSE165399 of PAAD to obtain the specific cell clusters. We then obtained cell cluster-associated gene modules by weighted co-expression network analysis and identified tumorigenesis-associated cell clusters and gene modules in PAAD by trajectory analysis. Tumor-associated genes of PAAD were intersected with cell cluster marker genes and within the signature module to obtain genes associated with PAAD occurrence to construct a prognostic risk assessment tool by the COX model. The performance of the model was assessed by the Kaplan–Meier (K-M) curve and the receiver operating characteristic (ROC) curve. The score of endocrine pathways was assessed by ssGSEA analysis.ResultsThe PAAD single-cell dataset GSE165399 was filtered and downscaled, and finally, 17 cell subgroups were filtered and 17 cell clusters were labeled. WGCNA analysis revealed that the brown module was most associated with tumorigenesis. Among them, the brown module was significantly associated with C11 and C14 cell clusters. C11 and C14 cell clusters belonged to fibroblast and circulating fetal cells, respectively, and trajectory analysis showed low heterogeneity for fibroblast and extremely high heterogeneity for circulating fetal cells. Next, through differential analysis, we found that genes within the C11 cluster were highly associated with tumorigenesis. Finally, we constructed the RiskScore system, and K-M curves and ROC curves revealed that RiskScore possessed objective clinical prognostic potential and demonstrated consistent robustness in multiple datasets. The low-risk group presented a higher endocrine metabolism and lower immune infiltrate state.ConclusionWe identified prognostic models consisting of APOL1, BHLHE40, CLMP, GNG12, LOX, LY6E, MYL12B, RND3, SOX4, and RiskScore showed promising clinical value. RiskScore possibly carries a credible clinical prognostic potential for PAAD.