bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression
Authors: Lei Dan , Xiao Wenyong , Zhang Bo 
Published: August 2023

Abstract

Background
Recent studies have highlighted that circular RNAs regulate cancer-related genes’ expression by functioning as microRNA sponges in cancers. Herein, we investigated the function and molecular mechanism of circYIPF6 in glioma.

Methods
5-Ethynyl-2′-deoxyuridine assay, colony formation, and flow cytometry were performed to assess the proliferation and apoptosis of glioma cells. The levels of glycolytic metabolism were evaluated by measuring the glucose uptake and lactate production. The protein levels of Bax, Bcl2, GLUT1, LDHA, and PTBP1 were examined by western blot. The interplay between miR-760 and circYIPF6 or PTBP1 was confirmed by a dual-luciferase reporter. The effect of circYIPF6 silencing on the growth of glioma in vivo was determined by a xenograft experiment.

Results
circYIPF6 was significantly upregulated in glioma. Knockdown of circYIPF6 suppressed glioma cell proliferation and glycolysis while promoting cell apoptosis. Mechanistic studies revealed that circYIPF6 targeted miR-760 and could abundantly sponge miR-760 to inhibit the expression of its downstream target gene PTBP1. Functional rescue experiments showed that both miR-760 inhibition and PTBP1 overexpression could attenuate the regulatory effect of circYIPF6 silencing on glioma cells. Furthermore, circYIPF6 knocking down effectively impeded glioma growth in vivo.

Conclusion
These findings suggested that circYIPF6 participated in the proliferation, apoptosis, and glycolysis of glioma through the miR-760/PTBP1 axis.
Towards Humanistic Management in professional sports: How to make mobility and fan-related tourism more sustainable?
Authors: Zitzke Arne , Brand Alexander , Reiser Dirk 
Published: August 2023

Abstract
Ideas of (a more) humanistic management have taken hold in multiple tourism contexts. In particular, we can see this in specific niches of tourism such as sports-related mobility and adjacent forms of athlete and fan travel, it has become more commonplace to pay attention to questions of ecological integrity as well as sustainability. Rather than being mere rhetorical exercises to create the appearance of more responsible practices (a ‘CSR façade’), substantial changes seem to be underway, through which authentic transformation towards genuinely humanistic management practices may be possible. We take the case of the inclusion of sustainability considerations in the organisation of team and fan travel alongside professional football in Germany to highlight such incremental change. While far from constituting mass phenomena, any such reforms have the capacity to set a trend, and to re-orient business practices across larger industries. Based on a qualitative case study of five professional football teams in Germany and their recently adjusted mobility activities, we argue that sports-related tourism and mobility management has the capacity to create role models in steering societies towards more sustainable, and hence: more humanistic modes of action.
WRKY transcription factors and OBERON histone‐binding proteins form complexes to balance plant growth and stress tolerance
Authors: Du Ping , Wang Qi , Yuan Dan‐Yang , Chen Shan‐Shan , Su Yin‐Na , Li Lin , Chen She , He Xin‐Jian 
Published: August 2023

AbstractWRKY transcription factors in plants are known to be able to mediate either transcriptional activation or repression, but the mechanism regulating their transcriptional activity is largely unclear. We found that group IId WRKY transcription factors interact with OBERON (OBE) proteins, forming redundant WRKY‐OBE complexes in Arabidopsis thaliana. The coiled‐coil domain of WRKY transcription factors binds to OBE proteins and is responsible for target gene selection and transcriptional repression. The PHD finger of OBE proteins binds to both histones and WRKY transcription factors. WRKY‐OBE complexes repress the transcription of numerous stress‐responsive genes and are required for maintaining normal plant growth. Several WRKY and OBE mutants show reduced plant size and increased drought tolerance, accompanied by increased expression of stress‐responsive genes. Moreover, expression levels of most of these WRKY and OBE genes are reduced in response to drought stress, revealing a previously uncharacterized regulatory mechanism of the drought stress response. These results suggest that WRKY‐OBE complexes repress transcription of stress‐responsive genes, and thereby balance plant growth and stress tolerance.
Análisis comparativo de las dimensiones de calidad de vida laboral en organizaciones de Colombia, América Latina y Europa.
Authors: Garzón Garzón Eliana Katherine , Parra Rodríguez Vanessa , Castillo Cruz Diana Marcela , Camacho Camacho Hernando 
Published: August 2023

La calidad de vida laboral es la satisfacción de los trabajadores ante la variedad de actividades, recursos y resultados generados de la participación en el lugar de trabajo, cuando los colaboradores perciben un gusto por su puesto de trabajo, se estimula la capacidad de trabajar, se demuestra interés y se realizan las tareas asignadas sin ningún inconveniente, aumentando así la satisfacción por el trabajo, aceptando labores desafiantes, persistiendo y adaptándose al cambio sin necesidad de abandonar su puesto de trabajo lo que genera productividad individual y organizacional, que se traduce en desempeño institucional.
En el presente artículo se realiza un análisis comparativo entre las dimensiones de calidad de vida laboral de diferentes organizaciones de Colombia, América Latina y Europa donde se identifican las dimensiones que se tienen en común y se analiza el aporte positivo que estas dimensiones generan en el desempeño de los trabajadores del sector solidario.
La metodología utilizada en este artículo de investigación se desarrolló mediante un enfoque mixto, dado que combina aspectos cuantitativos y cualitativos al momento de analizar los datos de la comparación de las encuestas de calidad de vida; como principal resultado de la investigación se evidencio que, para todos los países investigados, la dimensión común más importante es que las organizaciones les brinden a sus trabajadores un salario digno y justo.
Como conclusión relevante se determinó que no solo el factor monetario cumple las necesidades y expectativas de los trabajadores, por el contrario, para tener un impacto positivo eficaz en el desempeño de los colaboradores, se debe integrar las dimensiones tanto a nivel intelectual como afectivo, físico, socio -laboral, emocional y espiritual.
Plan de Integración de las Normas ISO 9001 e ISO 45001. Caso de estudio: Cooperativa de Ahorro y Crédito CANAPRO C.A.C. Tunja
Authors: Wilches Torres Laura Daniela , Mejia Espitia Miguel Leonardo , Cipagauta Esquivel Edna Carolina 
Published: August 2023

El objetivo de este estudio es proponer un modelo de integración basado en los Sistemas de Gestión de Calidad y Seguridad Salud en el Trabajo, aplicado a los procesos estratégicos, misionales y de apoyo del caso de estudio: Cooperativa CANAPRO C.A.C., conforme a las normas ISO 9001 e ISO 45001; esto debido a que la cooperativa actualmente cuenta con estos sistemas de gestión pero de forma independiente, lo que da origen a actividades repetitivas, duplicidad de documentación y procesos ineficientes, entre otros. Para tal fin, se definieron tres fases metodológicas; la primera orientada al diagnóstico inicial de los sistemas de gestión de la entidad, posteriormente la selección del método de integración según los lineamientos de la norma UNE 66177 como base para la realización de la propuesta de articulación de los dos sistemas de gestión ya mencionados, finalmente se propone una actualización al cuadro de mando con que cuenta la cooperativa con el fin de tener una herramienta que permita el monitoreo de cumplimiento de la propuesta de integración formulada. Se concluye que la integración de dichos sistemas de gestión genera aprovechamiento de tiempo y brinda a las partes interesadas información objetiva y sencilla que permite optimizar las dinámicas de la organización.
Evolución del proceso estadístico en Colombia a partir de referentes internacionales: Revisión bibliográfica
Authors: Gómez Arciniegas María del Pilar , Cerón Salas Suly Samira , Moreno Ingrid Carolina 
Published: August 2023

El Departamento Administrativo Nacional de Estadística – DANE define en su misión aspectos fundamentales en el desarrollo de un proceso estadístico desde la planeación, implementación y evaluación de la calidad estadística, teniendo como fin verificar el cumplimiento por parte de las entidades del Sistema Estadístico Nacional – SEN, de los lineamientos definidos para el proceso estadístico, y la Norma Técnica de Calidad del Proceso Estadístico (NTC PE 1000). Como resultado de las evaluaciones de calidad y de diferentes instrumentos de recolección (Plan Estadístico Nacional, 2020), se ha identificado que la producción de información estadística no cumple en su totalidad con los atributos requeridos. Por ello, se considera relevante identificar cuál ha sido la evolución del proceso estadístico en Colombia a partir de modelos internacionales; que orientan a las entidades del SEN para asegurar la calidad de la información y establecer un referente comparativo con la NTC PE 1000, norma que incorpora los lineamientos para el proceso estadístico en el país.
Esta investigación tiene enfoque cualitativo, realizando búsqueda sistemática de literatura a 37 artículos publicados entre 2004 y 2022, identificando10 dimensiones agrupadas en 3 variables: Estructura, aplicación internacional y nacional, que influenciaron la evolución del proceso estadístico colombiano.
Sistemas de gestión de innovación, caso Colombia: revisión sistemática de literatura
Authors: Barrera Gómez Marien Rocio , Alfonso Díaz Andres Leonardo , Dworaczek Conde Helga Ofelia 
Published: August 2023

El sistemas de gestión de innovación, es una estructura organizada y sistematizada, para el despliegue de una estrategia al interior de una organización permitiendo resultados impactantes a nivel de competitividad. En Colombia, esta estructura se estableció a través del compendio de normas voluntarias NTC 5800, las cuales se alinean con el contexto internacional aplicable al país.
El objetivo de esta investigación, fue determinar a través de una revisión sistemática de literatura, el alcance de los sistemas de gestión de innovación en Colombia, aplicando la metodología PRISMA. Esta se estructura a través de 27 ítems agrupados en 4 fases, que permitieron la construcción de un panorama desde lo general a lo particular, teniendo como fuentes de información la base de datos Scopus, con el soporte de información de instituciones oficiales.
Como resultado se identificó que, en Colombia, el sistema de gestión de innovación fue diseñado para ser integrado a otros sistemas existentes, como son calidad y medio ambiente. De igual manera, el marco de trabajo propuesto en el compendio, se alinea con estructuras internacionales como el Manual de Frascati y el Manual de Oslo, permitiendo a las organizaciones, el desarrollo de capacidades que mejoran su competitividad en un lenguaje global.
METODOLOGÍA PARA REALIZAR UN DIAGNÓSTICO INSTITUCIONAL PARA IMPLEMENTAR UN SISTEMA INTEGRADO DE GESTIÓN: CASO UNIVERSIDAD SANTO TOMÁS
Authors: González Gil Eduardo , Velásquez Nadia Verónica , Losada Rodriguez Sandra Jastri 
Published: August 2023

En este artículo se presenta la experiencia de la Universidad Santo Tomas en la primera fase de la implementación del Sistema Integrado de Gestión que se refiere a definir la metodología para la integración y la identificación de brechas de los sistemas de gestión que se integraran: sistema de gestión de la calidad, NTC – ISO 9001/2015; sistemas de gestión para organizaciones educativas, NTC – ISO 21001/2019; sistema de gestión ambiental NTC – ISO 14001/2015, sistema de gestión de la seguridad y salud en el trabajo NTC – ISO 45001/2018, en el marco del Sistema Institucional de Aseguramiento de la Calidad (SIAC).
Con la finalidad de identificar la madurez de los sistemas de gestión existentes en la Universidad y priorizar oportunidades de mejora para disminuir las brechas con relación al cumplimiento de los requisitos de los sistemas de gestión, se realizaron, en los lugares de desarrollo que tiene la universidad en el País, actividades de autodiagnóstico del cumplimiento de los requisitos de las normas internacionales; aplicación de encuestas de percepción a los grupos de interés de la comunidad universitaria y el desarrollo de preauditorias para validar el cumplimiento de requisitos de las normas ISO 14001, ISO 45001 e ISO 2100.
Como resultado se identificaron las brechas en relación a los requisitos de cada una de las normas evaluadas, y así mismo las diferencias entre cada uno de los lugares de desarrollo. Con base en esto, la Universidad definió un plan de acción para cumplir con todos los requisitos de las normas e iniciar un proceso de certificación. El primer logro de este ejercicio, es la obtención de la Certificación ISO 21001.
En conclusión, se identificó un avance significativo en la implementación de cada una de las normas y su valor para aportar a la gestión de la Universidad para el cumplimiento de su misión, así mismo se resalta como buena práctica el realizar autodiagnósticos y preauditorías externas que ayudan a optimizar recursos al unificar los requisitos transversales de cada sistema.
THE IMPACT OF COVID-19 ON MORTALITY IN CANCER PATIENTS IN THE INTENSIVE CARE UNIT
Authors: KARABACAK Pınar , BİNDAL Ahmet , ÖZDEN Eyyüp Sabri , ÖZCAN Mustafa Soner , OSMANLIOĞLU Hacı Ömer , KIRDEMİR Pakize 
Published: August 2023

Objective
New corona virus disease (COVID-19) is a respiratory
disease associated with high mortality that emerged
in December 2019. Individuals with preexisting health
conditions, such as heart disease, hypertension,
diabetes, and chronic obstructive pulmonary disease,
and those with weakened immune systems are at
increased risk for severe complications. Cancer
patients have been adversely affected by the pandemic,
both due to the disease itself and its treatments. The
aim of this study is to evaluate the impact of COVID 19
on mortality in cancer patients followed in the intensive
care unit (ICU).
Material and Method
We conducted a retrospective analysis of 275
COVID-19 patients who were admitted to the ICU
between January 2020 and April 2022. Among these
patients, 72 had a cancer diagnosis and were classified
into two groups: Group 1 (n=203) included patients
without cancer, and Group 2 (n=72) included patients
with cancer. We recorded age, gender, comorbidities,
PCR test results, laboratory parameters, APACHE2
and SOFA scores, duration of ICU stay, mechanical
ventilation requirement, and duration of mechanical
ventilation for all patients.
Results
Hypertension was significantly more common in Group
1 compared to Group 2 [97 (48%) and 24 (33%),
respectively); p
Millipede Diversity and Distribution in the Sirumalai Hills (Eastern Ghats), Tamil Nadu, India
Authors: Ramanathan B. , Gnanamani R. , Pathan T.S. , Indira Rani G. 
Published: August 2023

Millipedes are one of the significant terrestrial fauna in the forest ecosystem to decompose the plants' debris. Despite their environmental significance, records on millipede distribution are quite scarce and invalid in Tamil Nadu, India. The first investigation is an attempt to assess the population of millipedes at different elevation levels of Sirumallai Hills from July 2020 to June 2021. The number of millipedes was recorded using pitfall trapping and quadrant sampling. Millipede diversity and distribution in different elevations were evaluated with the help of Shannon’s and Simpson’s indexes and richness and evenness were estimated by standard methods. A total of 8 species of millipede belonging to the order Polydesmida, Sphaerotheriida and Spirobolida were recorded in lower, middle and higher elevations. Our results showed that Orthomorpha coarctata, Oxidus gracilis, Haphaphe haydeniana, Aulabolus newtoni and Trigoniulus corallinus species were in found all the elevations and most abundant in lower elevations. Arthosphaera magna, Arthosphaera dalyi and Arthosphaera distica species were abundant in middle elevations and scarce in upper and lower elevations. Diplopod species abundance and diversity were lesser in lower and higher elevations when compared to the middle elevation. Despite their richness similarities in all elevations, there were differences in the composition of the millipede species between the elevations.
The Predictors of the Consequences of Secondary Exposure to Trauma Among Professionals Working With Trauma Victims
Authors: Juczyński Zygfryd , Ogińska-Bulik Nina 
Published: August 2023

Helping those who have experienced trauma exposes the helpers to secondary traumatization. The mechanisms of its development are most often explained using the cognitive model of trauma processing. The aim of the research is to determine how disturbances of core beliefs and cognitive processing in the form of coping with stress are associated with secondary traumatic stress (STS) and secondary posttraumatic growth (SPTG). The study was conducted among psychologists and social workers (N = 240), working with people after traumatic experiences. Four standardized measurement tools were used. Based on the differential diagnosis, four types of consequences were identified. Discriminant analysis was used to establish the optimal configuration of predictors explaining the differences between the four subgroups. Two significant discriminant functions were significant, each identifies different beliefs and coping strategies. The first is associated with the disruptions of core beliefs about the world and cognitive processing in the form of a non-adaptive strategy; the second—with disturbed beliefs about oneself and adaptation strategies. Our results show a much greater exposure of social workers to the negative consequences of secondary traumatic stress disorder. A system of constant monitoring should be introduced, and the principles of prevention and therapy should be implemented.
Morbidity And Mortality In Very Low Birth Weight Infants: A Comparison Of Two Five-Year Periods With A 15-Year Interval
Authors: AKÇURA Yağmur Damla , ARMAĞAN Coşkun , AKYILDIZ Can , DELİLOĞLU Burak , DUMAN Nuray , TUZUN Funda , ÖZKAN Hasan 
Published: August 2023

Introduction and methods:
Thanks to developments in perinatal and neonatal care, the survival rate of premature babies has increased. Depending on the development level of countries and units, some of the morbidity rates may increase, while others may decrease. In this retrospective cross-sectional study; the morbidity and mortality results of very low birth weight (VLBW) infants were evaluated by comparing the results of the infants in our previous study and the data of developed countries.
Results:
203 infants were included in the last group. The mean birth weight of these babies was 976±308 g and the mean gestational age was 27.8±2.5 weeks. The rate of babies with a gestational age of 28 weeks and above were significantly lower than the first group containing 173 infants. Regarding major morbidities, the rates of bronchopulmonary dysplasia (moderate to severe) and necrotizing enterocolitis (>stage 2) were significantly higher in the last group; while the rates of retinopathy of prematurity (>grade 2), intraventricular hemorrhage (>grade 2) and periventricular leukomalacia were also similar among the two groups. While survival rates were found to be similar, the survival rate without major morbidity was significantly lower in the last group.
Conclusion:
While the survival rates remained unchanged despite the observation of smaller babies in terms of birth weight and gestational age in the last period when mortality and morbidity data were compared with developed countries, the study demonstrated a need for improvement in mortality rates especially in small gestational weeks, while major morbidity rates were generally encouraging.
Territórios sensíveis
Authors: Ribeiro Walmeri 
Published: August 2023

Partindo de uma breve introdução sobre a Performance como Pesquisa - PaR, esta escrita apresenta a metodologia, conceitos e procedimentos que fundamentam as ações desenvolvidas nos projetos da Plataforma Territórios Sensíveis. Ao longo do percurso de pesquisa que, por sua vez, atua no campo de diálogo entre arte e Antropoceno, alguns conceitos e procedimentos tornam-se basilares e serão aqui apresentados, como: experiência, processualidade, conhecimento corporificado, emergência e ecologias emergentes.
The Development and Investigation of the Diffusion-Stabilizing Burner with the Niche
Authors: Chernousenko Olga , Butovsky Leonid , Moroz Oleh , Kunyk Arsen , Khilimonchuk Dmutro 
Published: August 2023

The article presents the results of researches of the development and field tests in bench conditions of the microdiffusion stabilizer burner device of a rectangular slot type with a niche deepening along the entire perimeter of the burner. The air passes through a rectangular slot, gaseous fuel for combustion is supplied to the recirculation zone through a system of holes in the end wall of the stabilizer. On the side of the output end of the stabilizer, there is a niche deepening. As studies have shown, the niche deepening is an additional source of stabilization and intensification of torch burning. The experimental data and calculated dependences on the stabilization of the torch in the modes of “poor” disruption are obtained. It is shown that the stable operation of the burner on the lean limit expands – the coefficient of excess air increases with an increase in the width of the stabilizer, the diameter of the gas distribution holes, the coefficient of shading of the burner and air temperature, as well as with a decrease in the speed of the air flow. The research results showed that “rich” flame failure – flame failure with a gradual increase in gas flow occurs at air excess ratios less than unity. This ensures the reliable operation of the burner at the calculated operating modes with respect to the coefficient of excess air a = 1.15 – 6.0 and the air flow speed Wp = 12.0 m/s. A dependence was obtained that determines the influence of regime and design factors on the characteristics of a rich flare failure. The sustainability of the burner operation on the rich limit increases – the coefficient of excess air decreases, with an increase in the width of the stabilizer, the shading coefficient of the burner, air temperature and a decrease in air velocity. The experimental data and calculated dependences on the length of the combustion zone in the burner device are obtained. It was established that at the calculated coefficient of excess air a = 2.0 and higher coefficients, complete combustion of fuel occurs on the length of the combustion space X = 1000 mm. The relative length of the flame decreases when the shading coefficient of the burner and the air temperature increases. Measurements of harmful nitrogen oxides showed that the maximum content of oxides is observed at the coefficient of excess air a = 1.0 and is 125 mg/m3, which is less than the limit values which allowed by regulatory documents.