bluuebunny/crossref_metadata_2025_split huggingface dataset:
Porous materials: Covalent Organic Frameworks (COFs) as game-changers in practical applications, a review
Authors: Shahbaz Amsal , Ahmad Khalil , Qureshi Khizar , Majeed Hammad , Arshad Ifzan , Tabinda Tabinda , Iftikhar Tehreema , Kashaf-ul Khair  , Ashfaq Muhammad , Rehman Shah Habib Ur , Ahmad Muhammad Zubair , Lee Shern-long 
Published: September 2023

Abstract
Covalent Organic Frameworks (COFs) represents a class of remarkable porous materials composed of organic building blocks that are covalently linked in a periodic manner to form crystalline structures. High surface area, high porosity, tunable pore size, and high stability are their exceptional properties, which make them attractive candidates for various applications in the fields of catalysis, energy storage devices, biomedical applications, gas separation and storage applications. In fact, the great interest shown in COFs gave us a stimulus to review the output of the recent substantial efforts in this area. Meanwhile, the development of portable and sophisticated systems based on these particles is believed to create deeper insights for the scientists to embark on new investigations to pave the way for discovering new fundamental characteristics of COFs, modifications. Furthermore, the effect of modifications/fractionalizations on the performance of COFs will be thoroughly explained and challenging problems are mentioned. Moreover, the paper covers an inclusive collection of referenced recent research articles, providing readers with a comprehensive understanding of the subject matter and an extensive bibliography for further exploration. Through this comprehensive overview, the paper alleviates the noteworthy contributions of COFs in driving innovation and progress in a range of key scientific disciplines.
Exploring the anticancer potential of sulfate-hydroxy-butanone derivatives: insights from experimental and quantum chemical investigations
Authors: Owen Aniekan E. , Ime Emmah I. , Mbim Elizabeth N. , Edet Henry O. , Benjamin Innocent , Iniama Grace I. , Edet Uwem O. , Manicum Amanda-Lee E. , Louis Hitler 
Published: September 2023

Abstract
Urinary incontinence and erectile dysfunction represent enduring adverse outcomes resulting from prostate cancer, a leading cause of global mortality. Given this critical context, there exists an imperative to explore efficacious therapeutic interventions. In this context, a comprehensive investigation of the potential roles of 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2-butanone (CDR1), 4-(3ʹ-O-sulfate-4ʹ-hydroxyphenyl)-2(R)-butanol (CDR2), and dihydrodehydrodiconiferyl alcohol 9-O-sulfate (CDR3) as agents for prostate cancer is of paramount importance. These compounds, extracted from the mangrove plant Acrostichum aureum, have been meticulously characterized through GC-MS, FT-IR, and NMR analyses. Detailed insights into the molecular structures, reactivity, bonding nature, and vibrational behaviors of these studied compounds were gleaned via rigorous examination at the DFT/B3LYP-GD3BJ/6-311+G (d,p) level of theory. Moreover, in-depth in-silico molecular docking investigations were conducted, delineating their potential as agents against castration-resistant prostate cancer. Electronic assessments underscored the reactivity of the studied compounds, while analysis of natural bond orbitals affirmed their stability, thus signifying their prospective utility as potent anticancer agents. The bioactivity and compatibility profiles of the investigated compounds in relation to cancer proteins were meticulously evaluated through molecular docking analyses, and the results were meticulously benchmarked against recommended drugs. Among the discernible outcomes, compound CDR3 emerged as a standout candidate, boasting binding affinities of −6.7, −8.6, and −6.4 kcal/mol, predicated on pivotal hydrogen bonding interactions, which inherently dictate the potency of a potential therapeutic agent. Importantly, CDR3 exhibits promising characteristics as an anticancer agent, surpassing its counterparts, and even the recommended drug dorlutamide, thus positioning it favorably for further consideration in prostate cancer treatment modalities.
Rapid Weight Loss Practices Within Olympic Weightlifters
Authors: Gee Thomas I. , Campbell Paul , Bargh Melissa J. , Martin Daniel 
Published: September 2023

Abstract
Gee, TI, Campbell, P, Bargh, MJ, and Martin, D. Rapid weight loss practices within Olympic weightlifters. J Strength Cond Res 37(10): 2046–2051, 2023—Rapid weight loss (RWL) practices are common among athletes to “make weight” for a chosen bodyweight class. This study's purpose was to investigate RWL prevalence, magnitude, and methods within Olympic weightlifters from Great Britain. Subjects (n = 39, male = 22, female = 17) were recruited from International Weightlifting Federation lifting populations (mandatory two-hour competition weigh-in). Subjects were categorized into competitive groups based on Sinclair coefficient total (high, mid, low) and also gender (male, female). The validated Rapid Weight Loss Questionnaire was used to establish RWL magnitude and practices. Of respondents, 33 of 39 (84.6%) had purposely acutely reduced body mass to compete, a higher proportion present within females (94.1%) than males (77.3%). The cohort's mean habitual precompetition acute body mass loss was 3.8 ± 1.7% and the “rapid weight loss score” (RWLS) was 23.6 ± 9.5. Across competitive groups there were no significant differences in habitual or highest precompetition body mass loss, postcompetition body mass gain or RWLS (p > 0.05). However, females attributed a significantly greater “highest” relative precompetition body mass loss compared with males (7.4 vs 4.9%, p = 0.045). For RWL methods used, frequencies of “always” and “sometimes” were reported highest for “restricting fluid ingestion” (81.8%), “gradual dieting” (81.8%), and “water loading” (54.5%). The prevalence of RWL is high among competitive Olympic weightlifters, and especially within the sampled female athletes. Magnitude of RWL was similar across different standards of athlete; however, female lifters demonstrated a higher maximum precompetition RWL.
Reliability and Validity of Different Lower-Limb Strength Tests to Determine 1RM in the Keiser A300 Leg Press
Authors: Larsen Fredrik , Loturco Irineu , Sigvaldsen Eirik , Strand Martin Frank , Kalhovde John Magne , Haugen Thomas 
Published: September 2023

Abstract
Larsen, F, Loturco, I, Sigvaldsen, E, Strand, MF, Kalhovde, JM, and Haugen, T. Reliability and validity of different lower-limb strength tests to determine 1RM in the Keiser A300 leg press. J Strength Cond Res 37(10): 1963–1968, 2023—The aim of this study was to explore the reliability and validity of different lower-limb strength tests to determine the one-repetition maximum (1RM) value in the Keiser A300 leg press. Twenty-eight recreationally active subjects performed load-velocity (L-V) relationship, 1RM, isometric midthigh pull (IMTP), and maximal repetitions to failure (MRF) tests on 3 separated sessions. Predicted 1RMs for the L-V relationship were estimated from a linear regression equation, correlating movement velocity and relative loads. The number of repetitions from the MRF tests (at loads relative to bodyweight) and peak force from the IMTP tests were used in regression equations to predict 1RM. The level of significance was set to ρ ≤ 0.05. All 1RM prediction methods were highly comparable with the traditional 1RM test, as only trivial and nonsignificant differences were observed. Furthermore, the L-V relationship was the most reliable (intraclass correlation coefficient [± 95% confidence interval] = 0.99 [0.98, 0.996]; effect size = −0.01 [-0.38, 0.36], standard error of the measurement = 6.4 kg; coefficient of variation = 3.0 [2.2–3.8]% and valid (r = 0.95 [0.89, 0.98], effect size = 0.08 [-0.29, 0.45], standard error of the estimate = 20.4 kg; coefficient of variation = 7.4 [5.5–9.3]%) when compared with direct 1RM measurements. The L-V relationship test showed a significant change score relationship (r = 0.41 [0.04, 0.68]) against the direct 1RM measurements. In conclusion, the tests used in this study cannot be used interchangeably, but they represent a good alternative in training settings where 1RM testing is not feasible.
Time of Day Effects on Anaerobic Performance Using a Nonmotorized Treadmill
Authors: Renziehausen Justine M. , Bergquist Amy M. , Park Joon-Hyuk , Hill Ethan C. , Wells Adam J. , Stout Jeffrey R. , Fukuda David H. 
Published: September 2023

Abstract
Renziehausen, JM, Bergquist, AM, Park, J-H, Hill, EC, Wells, AJ, Stout, JR, and Fukuda, DH. Time of day effects on anaerobic performance using a nonmotorized treadmill. J Strength Cond Res 37(10): 2002–2007, 2023—The purpose of this study was to determine the effects of time of day on performance during a maximal effort sprinting assessment (30nmt) and determine potential differences based on chronotype and sex. Twenty-six recreationally active men (n = 12) and women (n = 14) between the ages of 18 and 35 years old (21.5 ± 2.4 years) completed the 30nmt at 9:00 am, 2:00 pm, and 7:00 pm in a randomized order over a 24-hour period. Resting heart rate and temperature assessments were taken at each visit. A dietary recall and the Morningness-Eveningness Questionnaire were used to assess kilocalories (kcals) and chronotype, respectively. Two-way (time x sex) repeated measures analyses of variance were conducted to determine differences in peak/mean power, peak/mean velocity, distance, resting heart rate, temperature, and kcals at each time point. Paired sample t tests were used to assess peak and nadir of each performance variable. A significance level was set at p < 0.05. There was a significant main effect for temperature (p < 0.001), resting heart rate (p = 0.007), and pre-exercise caloric intake (p = 0.021) throughout the day. No significant main effects for time were found for peak power (p = 0.766), mean power (p = 0.094), peak velocity (p = 0.497), mean velocity (p = 0.193), or distance (p = 0.262). There were no significant time × sex interactions for any dependent performance variables (p > 0.05). Significant differences were shown between the peak and nadir of each performance variable (p < 0.001). There were no significant differences in performance during maximal effort anaerobic assessments shown throughout the day; however, peak/nadir of performance times may be individualized and differ between morning types and intermediate types.
Spo13/MEIKIN ensures a Two‐Division meiosis by preventing the activation of APC/CAma1 at meiosis I
Authors: Rojas Julie , Oz Tugce , Jonak Katarzyna , Lyzak Oleksii , Massaad Vinal , Biriuk Olha , Zachariae Wolfgang 
Published: September 2023

AbstractGenome haploidization at meiosis depends on two consecutive nuclear divisions, which are controlled by an oscillatory system consisting of Cdk1‐cyclin B and the APC/C bound to the Cdc20 activator. How the oscillator generates exactly two divisions has been unclear. We have studied this question in yeast where exit from meiosis involves accumulation of the APC/C activator Ama1 at meiosis II. We show that inactivation of the meiosis I‐specific protein Spo13/MEIKIN results in a single‐division meiosis due to premature activation of APC/CAma1. In the wild type, Spo13 bound to the polo‐like kinase Cdc5 prevents Ama1 synthesis at meiosis I by stabilizing the translational repressor Rim4. In addition, Cdc5‐Spo13 inhibits the activity of Ama1 by converting the B‐type cyclin Clb1 from a substrate to an inhibitor of Ama1. Cdc20‐dependent degradation of Spo13 at anaphase I unleashes a feedback loop that increases Ama1's synthesis and activity, leading to irreversible exit from meiosis at the second division. Thus, by repressing the exit machinery at meiosis I, Cdc5‐Spo13 ensures that cells undergo two divisions to produce haploid gametes.
RNA‐based medicine: from molecular mechanisms to therapy
Authors: Sparmann Anke , Vogel Jörg 
Published: September 2023

AbstractRNA‐based therapeutics have the potential to revolutionize the treatment and prevention of human diseases. While early research faced setbacks, it established the basis for breakthroughs in RNA‐based drug design that culminated in the extraordinarily fast development of mRNA vaccines to combat the COVID‐19 pandemic. We have now reached a pivotal moment where RNA medicines are poised to make a broad impact in the clinic. In this review, we present an overview of different RNA‐based strategies to generate novel therapeutics, including antisense and RNAi‐based mechanisms, mRNA‐based approaches, and CRISPR‐Cas‐mediated genome editing. Using three rare genetic diseases as examples, we highlight the opportunities, but also the challenges to wide‐ranging applications of this class of drugs.
The post‐translational regulation of transcription factor EB (TFEB) in health and disease
Authors: Takla Michael , Keshri Swati , Rubinsztein David C 
Published: September 2023

AbstractTranscription factor EB (TFEB) is a basic helix–loop–helix leucine zipper transcription factor that acts as a master regulator of lysosomal biogenesis, lysosomal exocytosis, and macro‐autophagy. TFEB contributes to a wide range of physiological functions, including mitochondrial biogenesis and innate and adaptive immunity. As such, TFEB is an essential component of cellular adaptation to stressors, ranging from nutrient deprivation to pathogenic invasion. The activity of TFEB depends on its subcellular localisation, turnover, and DNA‐binding capacity, all of which are regulated at the post‐translational level. Pathological states are characterised by a specific set of stressors, which elicit post‐translational modifications that promote gain or loss of TFEB function in the affected tissue. In turn, the resulting increase or decrease in survival of the tissue in which TFEB is more or less active, respectively, may either benefit or harm the organism as a whole. In this way, the post‐translational modifications of TFEB account for its otherwise paradoxical protective and deleterious effects on organismal fitness in diseases ranging from neurodegeneration to cancer. In this review, we describe how the intracellular environment characteristic of different diseases alters the post‐translational modification profile of TFEB, enabling cellular adaptation to a particular pathological state.
In vitro fertilization program in white rhinoceros
Authors: Hildebrandt Thomas Bernd , Holtze Susanne , Colleoni Silvia , Hermes Robert , Stejskal Jan , Lekolool Isaac , Ndeereh David , Omondi Patrick , Kariuki Linus , Mijele Domnic , Mutisya Samuel , Ngulu Stephen , Diecke Sebastian , Hayashi Katsuhiko , Lazzari Giovanna , de Mori Barbara , Biasetti Pierfrancesco , Quaggio Alessandra , Galli Cesare , Goeritz Frank 
Published: September 2023

In brief
To save endangered rhinoceros species, assisted reproductive technologies are warranted. We here report in vitro blastocyst generation of the Near-Threatened Southern white rhinoceros and, for the first time, also of the technically Extinct Northern white rhinoceros.

Abstract
The Anthropocene is marked by a dramatic biodiversity decline, particularly affecting the family Rhinocerotidae. Three of five extant species are listed as Critically Endangered (Sumatran, Javan, black rhinoceros), one as Vulnerable (Indian rhinoceros), and only one white rhino (WR) subspecies, the Southern white rhinoceros (SWR), after more than a century of successful protection is currently classified as Near Threatened by the IUCN, while numbers again are declining. Conversely, in 2008, the SWR’s northern counterpart and second WR subspecies, the Northern white rhinoceros (NWR), was declared extinct in the wild. Safeguarding these vanishing keystone species urgently requires new reproductive strategies. We here assess one such strategy, the novel in vitro fertilization program in SWR and – for the first-time NWR – regarding health effects, donor-related, and procedural factors. Over the past 8 years, we performed 65 procedures in 22 white rhinoceros females (20 SWR and 2 NWR) comprising hormonal ovarian stimulation, ovum pick-up (OPU), in vitro oocyte maturation, fertilization, embryo culture, and blastocyst cryopreservation, at an efficiency of 1.0 ± 1.3 blastocysts per OPU, generating 22 NWR, 19 SWR and 10 SWR/NWR hybrid blastocysts for the future generation of live offspring.
Qualidade de vida e sobrecarga de mães de crianças com microcefalia
Authors: Conceição dos Santos Daniel Batista , Costa Cardoso Luana da Conceição , Barbosa Torales Andréia Poschi , Prado Reis II Francisco , Costa da Cunha Oliveira Cristiane , Oliveira Lima Sonia 
Published: September 2023

Introdução: Devido a infecção congênita, a criança com microcefalia possui grandes limitações de sua condição de saúde. Estas limitações fazem com que a criança necessite de maior atenção de saúde e domiciliar. Geralmente, a mãe torna-se cuidadora principal desta criança, esse papel pode levar a sobrecarga com prejuízos em sua qualidade de vida.
Objetivo: Analisar sobrecarga do cuidado e a qualidade de vida de mães ou cuidadoras principais de crianças com microcefalia relacionada à infecção congênita.
Método: Estudo transversal, correlacional, realizado com 105 participantes do estado de Sergipe, Brasil, durante o período de outubro de 2017 a abril de 2018, através da aplicação questionários: sociodemográfico, WHOQOL-Bref e Sobrecarga do cuidador. Para análise estatística foram utilizados testes ANOVA, teste t e Person (r).
Resultados: A totalidade dos participantes era do sexo feminino, 39 % foram classificadas com sobrecarga severa e 30,5% com sobrecarga intensa. A média total da sobrecarga (49,47) indica classificação de moderada à severa. Houve uma forte associação (p<0,0001) entre os níveis de sobrecarga e os domínios da qualidade de vida, sendo o de maior prejuízo o ambiental (36,57) e o físico (38,53). Foi observada uma correlação significativa e inversamente proporcional (r=-0,547, p<0,0001) entre a qualidade de vida e a sobrecarga do cuidador.
Conclusão: As mães sofrem sobrecarga severa e intensa que pode levar a repercussões negativas em sua qualidade de vida. A enfermagem pode contribuir na criação e implementação de linhas de cuidados específicas para estas mulheres com ênfase na promoção da saúde física, mental e melhora da qualidade de vida.
Report on the Creation of the "Sense of Vision" Application Using Android-Based Augmented Reality Technology
Authors: Setiyawati Siska Dyah , Falah Muhammad , Pramudhita Tesyalonika Dhevina , Hadi Rizdha Buwana , Yulaikha Yulaikha 
Published: September 2023

Making the "Sense of Sight" application using Android-based augmented reality technology is an innovation that was created as a means to help elementary school children understand natural sciences class IV (four) theme 5 material on the sense of sight more effectively and interactively. When viewed in terms of the theoretical benefits of research, this research was created in order to provide a new concept in the world of education and can be used as reference material for further similar research. Then, the practical benefit of this research is that researchers gain knowledge to apply a technology in learning in the form of an application and can be used by students so that learning will be more effective and enjoyable. The results of this study are in the form of visual sensory application products using Android based Augmented Reality technology, which teachers can use as one of the learning media on theme 5, namely the sense of sight
FÓRMULAS RUTINARIAS EN EL ESPAÑOL COLOQUIAL DE MEDELLÍN Y SU ÁREA METROPOLITANA
Authors: García Zapata Carlos 
Published: September 2023

Este artículo analiza el significado de las fórmulas rutinarias de uso frecuente en el español hablado en la ciudad de Medellín y su área metropolitana. Para tal fin, se mencionan, en la primera parte, los antecedentes y aspectos teóricos característicos de dichas fórmulas; luego, se señala la metodología de análisis utilizada, según la modalización en su doble distinción de modalidad del enunciado y modalidad de la enunciación. Finalmente, entre las conclusiones del estudio, se hace énfasis en el significado que puede esclarecerse en las fórmulas analizadas, a partir de los diferentes tipos de modalidad: epistémica, deóntica y subjetiva.
COLONIA CHINA EN EL PERÚ COMO REGIÓN CULTURAL DISEMINADA EN EL TRAMO FINAL DE SIU KAM WEN
Authors: Vela Diana 
Published: September 2023

Los cuentos reunidos en El tramo final (1986) del escritor chino-peruano Siu Kam Wen (Guangdong, 1951) despliegan a la colonia china en el Perú como una región cultural diseminada. Esta región se configura en la medida en que los chinos, tras despojarse del estigma de inferioridad que los marcó en un inicio, diseminan sus raíces por diferentes zonas y estratos de la ciudad de Lima, e incluso, por latitudes que se erigen más allá de la misma.
REGIONES, ETNICIDAD Y LITERATURA EN COLOMBIA: LECTURAS ABIERTAS DE MANUEL ZAPATA OLIVELLA
Authors: Sandoval Correa Sergio Andrés 
Published: September 2023

La estrecha vinculación entre el hombre y su territorio, entre la literatura y su región, es estudiada por Zapata Olivella desde una mirada étnica, antropológica, estética, histórica y social, basándose en las herencias de diversos continentes, en la geografía y en las expresiones tradicionales. Por esto, las regiones adquieren tanta importancia en los libros del escritor colombiano, directamente relacionadas con los grupos étnicos que las habitan. Las concepciones de literatura como facultad creadora del ser humano y de las regiones como espacios culturales, son leídas de manera abierta con el objetivo de buscar diversas relaciones entre regiones, etnicidad y literatura.
CUESTIÓN MODERNO-COLONIAL EN EL PAPEL PERIÓDICO (1791-1796): LAS PRÁCTICAS ILUSTRADAS DE MANUEL DEL SOCORRO RODRÍGUEZ
Authors: Moreno Chuquen Liz 
Published: September 2023

El artículo se propone establecer las características y paradojas derivadas de la irrupción, recepción y reelaboración de las ideas, valores y prácticas Ilustradas provenientes de España en las últimas décadas del siglo XVIII en Nueva Granada y que configuran una experiencia moderna particular. El concepto de modernidad europea se presenta brevemente a través de uno de sus estudiosos más representativos en contraste con la perspectiva de Aníbal Quijano quien introduce la colonialidad como uno de los elementos más importantes para la consolidación de la modernidad europea y de las experiencias modernas en los territorios objeto de colonización. La experiencia neogranadina se aborda y analiza a través del Papel periódico.
“CONTANDO DESPUÉS DE MUERTA”
Authors: Pérez Sastre Paloma 
Published: September 2023

En su obra Impresiones de viaje (escritas por una abuela para sus nietos), Isabel Carrasquilla expresa desde un principio su deseo de “seguir contando después de muerta”. Este detalle y las circunstancias que rodearon la escritura del libro en 1931, a los 66 años, a escondidas de su hermano Tomás —a la sazón del más célebre escritor antioqueño—, permiten pensar en una fuerte pero oculta necesidad de expresión estética. Con el fin de identificar las marcas de una subjetividad creadora, este artículo, luego de algunas consideraciones sobre el género literario en el que se inscribe la obra, se detiene en la relación entre este y la intención de la autora, para terminar mostrando las facetas que asume la auto-representación.