bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Canadian Landscape of Genetics and Genomics in Nursing: A Policy Document Analysis
Authors: Puddester Rebecca , Limoges Jacqueline , Dewell Sarah , Maddigan Joy , Carlsson Lindsay , Pike April 
Published: March 2023

Background Genetics and genomics (GG) are transforming approaches to healthcare in Canada and around the globe. Canadian nurses must be prepared to integrate GG in their practice, but modest research in this area suggests that Canadian nurses have limited GG competency. Countries that have integrated GG across nursing provided guidance to nurses about the practice implications of GG through regional nursing policy documents. These documents propelled action to integrate GG across nursing. Little is known about the GG content in the nursing policy document infrastructure in Canada. Purpose This study aimed to examine the guidance for GG-informed nursing practice as provided by Canadian nursing organizations in official professional documents. Methods Qualitative document analysis was used. A hybrid inductive/deductive analysis approach was used to analyze findings within the diffusion of innovation theory framework. Results There is an overall lack of depth and breadth of Canadian nursing documents that include content related to GG. Of the (n  =  37) documents analyzed, four themes were generated including (a) GG guidance in nursing education; (b) regulators’ requirements for foundational GG knowledge, (c) Canadian Nurses Association (CNA) as an early catalyst to GG integration; and (d) early adopters in speciality practice. Conclusion There are opportunities to enhance the guidance available to Canadian nurses for the application of GG, through documents of nursing professional associations, nursing education accreditation organizations, and regulatory bodies. Findings suggest oncology and perinatal nurses are the early adopters which is an important consideration in future strategies to implement GG into Canadian nursing.
Rural Home Care Nursing During COVID-19
Authors: Pavloff Michelle , Labrecque Mary Ellen , Bally Jill , Kirychuk Shelley , Lasiuk Gerri 
Published: March 2023

Background The SARS-CoV-2 (COVID-19) pandemic continues to be a challenging time for the nursing profession globally. Research indicates that the care of patients with COVID-19 has caused significant psychological stress for nurses. Although much of the world's attention has been on nurses working in emergency departments and intensive care units, the pandemic also posed significant challenges for nurses providing home care services in rural communities. Purpose The purpose of this work was to describe the experiences of rural Canadian home care nurses during the early stages of the COVID-19 pandemic. Methods The data for this analysis was derived from a study that explored the continuing education needs of rural home care nurses. Since the data collection for the primary objective occurred in the early stages of the COVID-19 pandemic, COVID-19 related themes were created using interpretive description methodology. Snowball and purposive sampling were used to recruit rural home care registered nurses who were employed in the central and southern areas of a western Canadian province. Results Six themes were constructed from the data including: Nurses Must Work, Constant State of Flux, Threatened Safety, Loss of Learning Opportunities, Fearing the Unknown, and Hindsight is Easy. Conclusion The experiences of rural home care nurses during COVID-19 reflects the chaos, uncertainty, and fear that was felt globally. Based on the findings of this study, recommendations for future pandemic planning are suggested.
Frequency of Physical Activity Done with a Companion: Changes Over Seven Years in Adults Aged 60+ Living in an Australian Capital City
Authors: Smith Genevieve S. E. , Moyle Wendy , Burton Nicola W. 
Published: March 2023

Objectives:This study examined how often adults 60+ years were physically active with a partner, close family, friends, and neighbors, over 7 years. Methods: Data from 2062 adults living in an Australian capital city were collected using a mail survey at four time points and analyzed using multinomial logistic regression. Results: A partner was the most frequent companion at all time points. From baseline to 7 years, the greatest decline was activity with family 1–4x/month (.79 [.64–.98]) and ≥5x/month (.54 [.36–.80]). There were also decreases in activity 1–4x/month with a partner (OR = .75, [.62–.92]), friends (.55 [.44–.68]), and neighbors (.79 [.64–.98]). Physical activity with friends or neighbors ≥5x/month did not decline. Discussion: Findings extend understanding of physical activity and activity companions among older adults. More research is needed to understand factors contributing to changes in activity done with companions.
Efficacy of Demineralized Bone Matrix for Revision Alveolar Bone Grafting in Patients Previously Treated with Bone Morphogenetic Protein 2 (BMP-2)
Authors: Francoisse Caitlin A. , Sescleifer Anne M. , Okeke Raymond I. , Tyson Cody V. , Plikaitis Christina 
Published: March 2023

Objective This study investigates the effectiveness of demineralized bone matrix (DBX) to close alveolar clefts in patients previously treated with bone morphogenic protein-2 (BMP-2) who remained with bone nonunion. Design This is an IRB-approved retrospective, single-center study. Setting This study was conducted at a tertiary academic center Patients/Participants We searched for all surgical encounters with the Current Procedural Terminology (CPT) code 42210 from the years 2013–2019. Included patients were diagnosed with cleft alveolus, previous BMP-2 exposure and required revision bone grafting during mixed dentition for persistent alveolar defects. Interventions 17 patients underwent revision alveolar bone grafting (ABG) with either DBX (n = 10) or autograft (n = 7) to repair persistent bony cleft. Main Outcome Measure(s) The primary study outcome measured was alveolar bone graft revision failure described as continued alveolar nonunion. Results The median age at revision ABG was 13.1 ± 3.3 years, with a mean follow-up time of 4.9 years (1.1–9.2 years). Patients were 53% male, 47% had a unilateral cleft lip and alveolus. 58.8% of patients were treated with DBX in the cleft, 41.2% treated with autograft from iliac crest. Overall, 11.8% (n = 2) of all revisions failed, requiring a second revision. The average time to reoperation was 2.06 years, and both were re-grafted with autograft. There was no statistically significant difference between the type of bone graft source used and the failure rate obtained ( P = .1544). Conclusions DBX and autologous iliac crest bone grafts achieve similar alveolar union rates during revision ABG in patients treated with previous BMP-2 to the alveolar cleft.
Topical netarsudil for treatment of glaucoma with elevated episcleral venous pressure: A pilot investigation in sturge-weber syndrome
Authors: Kaufman Aaron R , Elhusseiny Abdelrahman M , Edward Deepak P , Vajaranant Thasarat Sutabutr , Aref Ahmad A , Abbasian Javaneh 
Published: March 2023

Purpose Topical netarsudil 0.02% may reduce intraocular pressure (IOP) by decreasing episcleral venous pressure (EVP), which carries theoretical utility for glaucoma associated with elevated EVP. A role for netarsudil in patients with elevated EVP is evaluated in a pilot investigation using a cohort of individuals with Sturge-Weber syndrome (SWS). Methods Retrospective study of patients with SWS and glaucoma who were treated with netarsudil. Five patients (six eyes) were identified. Data collected included demographics, visual acuity, IOP, glaucoma medical and surgical treatments, and adverse effects of netarsudil. Results Mean age was 13.6  ±  8.5 years. EVP elevation was presumed based on clinical stigmata and/or historical features. Mean number of baseline glaucoma medications was 3.3  ±  1.2. There was a significant reduction in the IOP at netarsudil initiation (mean 26.2  ±  4.5 mmHg) to 1 month of netarsudil therapy (mean 20.2  ±  3.8 mmHg, p  =  0.0283 ) and latest IOP on netarsudil (mean 17.6  ±  1.4 mmHg, p  =  0.0034). Mean duration of netarsudil therapy was 18.7  ±  11.8 months. Three patients required additional glaucoma procedures; one patient required an additional glaucoma medication. Three eyes (50%) developed conjunctival hyperemia. One patient discontinued netarsudil at 29 months, to reduce drop burden. Conclusions Netarsudil can effectively reduce IOP in patients with SWS, even when used as a fourth or fifth glaucoma medication. A possible role for netarsudil in the management of patients with elevated EVP is suggested pending further future investigations.
The influence of corneal tunnel length on surgically induced astigmatism after various types of microincision phacoemulsification
Authors: Wilczynski Michal , Kucharczyk-Pospiech Magdalena , Omulecki Wojciech 
Published: March 2023

Purpose To evaluate the influence of the corneal tunnel length on surgically induced astigmatism (SIA) after 3 phacoemulsification techniques. Methods Patients who underwent a planned phacoemulsification surgery with an implantation of a foldable, acrylic IOL were selected for the study. All surgeries were performed under topical anaesthesia, with the same phaco machine. Group I consisted of 30 eyes of 30 patients after bimanual 1.4 mm microincision cataract surgery (B-MICS). Group II consisted of 30 eyes of 30 patients after coaxial 1.8 mm microincision cataract surgery (C-MICS). Group III consisted of 30 eyes of 30 patients after coaxial 2.4 mm small incision cataract surgery (C-SICS). Best corrected visual acuity, autorefractometry, tonometry, a slit lamp examination and anterior segment OCT were performed preoperatively and 1, 7, 30 and 90 days postoperatively. The temporal peripheral corneal thickness and the chord length of the main incision were measured. Vector method was used to calculate SIA. Results Mean preoperative BCVA was 0.52 ± 0.19 and it improved to 0.98 ± 0.05 (p < 0.05). Mean corneal tunnel chord length was 1.30 ± 0.16 mm 90 days postoperatively in group I, 1.30 ± 0.19 mm in group II and 1.48 ± 0.22 mm in group III. SIA was 0.54 ± 0.48 mm in group I, 0.45 ± 0.21 mm in group II and 0.62 ± 0.30 mm in group III. There were no correlations between the chord length of the corneal tunnel and SIA calculated with using vector analysis method. Conclusions Unlike the incision width, the length of the clear corneal tunnel in small incisions and microinicions, has no significant influence on SIA.
A randomized trial comparing percutaneous endoscopic gastrostomy (PEG) and radiologically inserted percutaneous gastrostomy (RIG)
Authors: Sundbom Magnus , Cabrera Eladio , Nyman Rickard , Barbier Charlotte Ebeling , Johnson Ulf , Ljungdahl Mikael 
Published: March 2023

Background and objective: At present, percutaneous endoscopic gastrostomy (PEG) is the procedure of choice in establishing a permanent feeding tube in patients with chronic severe dysphagia. This is the first prospective randomized study in adults comparing PEG with radiologically inserted gastrostomy (RIG). Methods: Randomization of 106 patients, eligible for both techniques, to PEG (pull method) or RIG. The groups were comparable in terms of age, body mass index, and underlying diseases. Adverse events were reported 10 and 30 days after the operative procedure, and mortality was up until 6 months. The validated European Quality of life 5 Dimensions 3 level version (EQ-5D) questionnaire was used for health status measurements. Results: The procedures were successfully completed in all patients. The median operative time was 10 min for PEG and 20 min for RIG (p < 0.001). The overall rate of adverse events was lower for PEG (22%) than for RIG (51%, p = 0.002), mostly due to less local self-limiting stoma reactions and tube problems. The 30-day mortality was lower after PEG (2% versus 14%, p = 0.020). Patient-scored health status remained low for the entire cohort, with an EQ-5D utility index of 0.164. Self-rated health was low but improved in the RIG group (52.5 from 41.1, out of 100). Conclusion: PEG can be recommended as the primary procedure in patients in need of a feeding gastrostomy, mainly due to a lower frequency of tube complications. However, as the two techniques complement each other, RIG is also a valid alternative method. Clinical trial registration: International Standard Randomized Controlled Trial Number ISRCTN17642761. https://doi.org/10.1186/ISRCTN17642761
Blood management practices during rapid transfer of urgent trauma patients pre- and post-implementation of ROTEM®-guided transfusion
Authors: Wyssusek Kerstin H. , Wagner Matthew K. , Lee Julie , Okano Satomi , Wullschleger Martin , van Zundert André A. 
Published: March 2023

Objective The ‘Red Blanket’ protocol fast tracks trauma patients with severe blood loss to the designated trauma operating theatre directly from the hospital helipad or Emergency Department. This study aimed to assess the impact of patient blood management (PBM) strategies on severely injured trauma patients treated under the ‘Red Blanket’ protocol at a quaternary referral hospital. Methods This retrospective review was conducted on all urgent trauma cases that were treated under the ‘Red Blanket’ protocol in a ten-year period between January 2007 and December 2017. The use of blood products and patient outcomes was compared between the 3.5-year periods pre- and post-ROTEM® implementation on 30th June 2014 (Jan 2011-June 2014 versus July 2014-Dec 2017). Results During the study period, 120 trauma patients were treated under the ‘Red Blanket’ protocol at our institution. Intention to treat analysis showed a reduction in fresh frozen plasma usage following the introduction of ROTEM®-guided transfusion. Furthermore, subgroup analysis suggested reduced blood product usage in patients who survived. Conclusions Patient blood management is a coordinated package of systems and tools, including education, patient logistics, anaemia management, intraoperative cell salvage, rotational thromboelastometry and massive transfusion protocols that together conserve blood products and improve outcomes. The implementation of ROTEM®-guided transfusion demonstrated a reduction in fresh frozen plasma usage.
Numerical simulation of actuation processes and decoupling pyroshock of a pressure cartridge-type pin puller
Authors: Wang Jingcheng , Xiong Shihui , Wen Yuquan , Wang Yadong 
Published: March 2023

In this study, a finite element model of a pressure cartridge-type pin puller is used to simulate the actuation process and predict the actuation shock using the deflagration equation of state and the fluid-structure coupling algorithm of the MSC/Dytran. The established model is validated by comparing the simulation results with the experimental results for pressure and actuation shocks. Based on the established finite element model, the contribution of the four shock sources to the actuation shock is quantitatively decoupled by changing the state of the pin puller. The results demonstrate that the maximum shock caused by the piston impact was 7454.33 G in the analysis frequency range of 500 Hz–10 kHz. The piston impact was the primary contributor to the actuation shock, accounting for approximately 80.80%. The contribution of the shock caused by payload release was approximately 18.56%. However, the total contributions of the shock generated by the pyrotechnic charge combustion and piston cutting off the shear pin were less than 1%. The conclusions of this study can provide a reference for the structural and shock-reduction design of pressure cartridge-type pyrotechnic separation devices.
A bicultural model of social work with immigrants: Professional interventions, acculturation orientations, and burnout of social workers
Authors: Tartakovsky Eugene , Baltiansky Gil 
Published: March 2023

Summary In the present study, we developed a bicultural model of social work with immigrants consisting of professional interventions rooted in the dominant and the immigrant cultures. We further developed scales measuring the two types of interventions and investigated their connections with acculturation orientations and burnout of social workers working with immigrants from the Former Soviet Union (FSU) in Israel. The study was cross-sectional. The sample included 313 social workers, 254 Israeli-born and 59 born in the FSU. The data were analyzed using structural equation modeling. Findings In their work with immigrants, social workers equally used interventions rooted in the immigrant and the dominant cultures, and the two types of interventions were complimentary. Stronger adherence to the acculturation orientation related to preserving the immigrant culture was associated with more frequent use of interventions rooted in the immigrant culture. In addition, more frequent interventions rooted in the immigrant culture were associated with a higher level of personal accomplishment. On the other hand, more frequent use of interventions rooted in the dominant culture was associated with a higher level of burnout. Immigrant social workers reported a higher level of personal accomplishment but also a higher level of burnout than their colleagues belonging to the dominant group. Applications The main conclusion of the present study relates to the importance of accepting the immigrant culture and learning to effectively apply professional interventions rooted in both the immigrant and the dominant cultures in social work with immigrants.
Nanokaolin reinforced carboxylated nitrile butadiene rubber/polyurethane blend-based latex with enhanced tensile properties and chemical resistance
Authors: Aung QL , Chow WS , Yong YP , Lam CN 
Published: March 2023

The demand for gloves (e.g., disposable gloves, medical gloves) is increasing due to the Coronavirus disease 2019 (COVID-19) pandemic. Stability in the supply chain in the glove industry is important, and thus strategies are used to solve the problem of the shortage of nitrile gloves. The blending of nitrile butadiene rubber (NBR) with polyurethane (PU) and the use of the nanocomposite concept is among the feasible approaches. The present study aims to investigate the effects of nanokaolin (NK) on the tensile and chemical properties of carboxylated nitrile butadiene rubber (NBR)/polyurethane (PU) latex blends. Three different loadings of NK (10, 20, and 30 parts per hundred rubber) were added to the NBR/PU (at a blending ratio of 85/15). The zeta potential showed that all the NBR compounds exhibit good colloidal stability. The incorporation of NK increased the crosslink density and tensile strength of the NBR/PU latex blends. The highest tensile strength was achieved when the NK loading was 20 phr. All the NBR blends and nanocomposites (NBR/PU-based) possess tensile properties that fulfill the requirements for glove application. The chemical resistance of NBR compounds was increased by the incorporation of NK due to the higher crosslink density and barrier properties contributed by the NK.
Age of asthma onset does not impact the response to omalizumab
Authors: Rogers Linda , Holweg Cecile TJ , Pazwash Hooman , Ko Jinnie , Louie Samuel 
Published: March 2023

Different ages of asthma onset can lead to similar clinical symptoms but have different underlying mechanisms that may influence treatment response. This post-hoc analysis assessed response to omalizumab in relation to the age of asthma onset. Using pooled data from two phase III studies (patients 12–75 years), changes in exacerbation rates, forced expiratory volume in 1 second (FEV1) and inhaled corticosteroids (ICS) were assessed by age of asthma onset (<18 [ n = 574], 18–40 [ n = 360], >40 years [ n = 136]). Exacerbations (week 16) were reduced with omalizumab versus placebo in all subgroups (relative rate reduction [95% confidence interval]: <18, −53.1% [–73.6,–16.6]; 18–40, −68.3% [–85.5,–31.0]; >40, −38.4% [–77.3,67.4]). FEV1 increased with omalizumab in all subgroups; increases were sustained in <18 and 18–40 years subgroups, but not in >40 years subgroup. ICS dose reductions (week 28) were greater with omalizumab versus placebo, regardless of age of asthma onset, as were percentages of patients with ICS doses reduced by at least 50% and 100%. In conclusion, omalizumab-treated patients had lower exacerbation rates and were more frequently able to reduce/discontinue ICS versus placebo, regardless of age of asthma onset, therefore omalizumab may be beneficial to all eligible patients with allergic asthma. Trial registration These studies were conducted before clinical trial registration was required; therefore, clinical trial registration numbers are not available.
Duplex-Guided Ipsilateral Antegrade Approach for Flush Superficial Femoral Artery Occlusion
Authors: Saleh Mahmoud Ismael , Ali Haitham , Gamal Walid M. , Taha Ashraf Gamal 
Published: March 2023

Objective Recanalization of flush ostial superficial femoral artery (SFA) occlusion is a very challenging procedure. Using the ipsilateral antegrade approach in such lesions has some difficulties. This study aimed to assess the feasibility, efficacy, and outcomes of duplex-guided ipsilateral antegrade access for endovascular treatment of atherosclerotic flush occlusion of the SFA. Methods This is a prospective two-center study that included chronic lower extremity ischemia patients with flush occlusion of SFA who underwent duplex-guided ipsilateral antegrade endovascular revascularization due to unfeasible contralateral femoral approach. Flush occlusions were preoperatively documented by duplex ultrasound and computed tomography angiography in all patients. The outcome measures were technical success, patency rates, perioperative morbidity and mortality, limb salvage, and amputation free survival rates. Results Between April 2019 and March 2021, 49 patients were enrolled in the current study with a mean age of 63.7 ± 5.7 years. Diabetes was the most common risk factor and was found in 40 (81.6%) patients. Associated popliteal lesions were found in seven (14.3%) patients, while 10 (20.4%) patients had combined tibial disease. Selective stenting was done in nine (18.4%) patients. Technical success was achieved in 43 (87.8%) patients. All failures were due to inability to cross the lesion rather than failure to access the common femoral artery. All complications were minor and occurred in seven (14.3%) patients. Primary, assisted primary, and secondary patency rates were 63.9% ± 7.1%, 82.8% ± 5.6%, and 93.5% ± 3.7% at 12 months, respectively. The overall 12-month limb salvage and amputation free survival rates were 91.8% and 83.3% ± 5.4%, respectively. Conclusion Duplex-guided ipsilateral antegrade femoral access is a feasible, safe, and effective endovascular treatment option for flush SFA occlusion when contralateral femoral access is not possible.