bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical coherence tomography for in vivo longitudinal monitoring of artificial dermal scaffold
Authors: Chen Ziye , Cheng Qiong , Wang Lingyun , Mo Yunfeng , Li Ke , Mo Jianhua 
Published: February 2023

AbstractObjectivesArtificial dermal scaffold (ADS) has undergone rapid development and been increasingly used for treating skin wound in clinics due to its good biocompatibility, controllable degradation, and low risk of disease infection. To obtain good treatment efficacy, ADS needs to be monitored longitudinally during the treatment process. For example, scaffold‐tissue fit, cell in‐growth, vascular regeneration, and scaffold degradation are the key properties to be inspected. However, to date, there are no effective, real‐time, and noninvasive techniques to meet the requirement of the scaffold monitoring above.Materials and MethodsIn this study, we propose to use optical coherence tomography (OCT) to monitor ADS in vivo through three‐dimensional imaging. A swept source OCT system with a handheld probe was developed for in vivo skin imaging. Moreover, a cell in‐growth, vascular regeneration, and scaffold degradation rate (IRDR) was defined with the volume reduction rate of the scaffold's collagen sponge layer. To measure the IRDR, a semiautomatic image segmentation algorithm was designed based on U‐Net to segment the collagen sponge layer of the scaffold from OCT images.ResultsThe results show that the scaffold‐tissue fit can be clearly visualized under OCT imaging. The IRDR can be computed based on the volume of the segmented collagen sponge layer. It is observed that the IRDR appeared to a linear function of the time and in addition, the IRDR varied among different skin parts.ConclusionOverall, it can be concluded that OCT has a good potential to monitor ADS in vivo. This can help guide the clinicians to control the treatment with ADS to improve the therapy.
Fabrication of Multifunctional Composite Nanofibers by Green Electrospinning
Authors: González Edurne , Barquero Aitor , Paulis Maria , Leiza Jose Ramon 
Published: February 2023

AbstractThe present work takes advantage of green electrospinning to create novel composite multifunctional nanofibers (NFs) bearing inorganic nanoparticles (NPs), more specifically quantum dots (QDs), cerium oxide nanoparticles (CeO2 NPs) and iron oxide nanoparticles (Fe3O4 NPs). This is achieved by first encapsulating the desired inorganic NPs into polymer particles by the use of miniemulsion polymerization, and second, spinning the hybrid polymer particles using polyvinyl alcohol (PVA) as template polymer. It is proved that using green electrospinning, it is not only possible to ensure an excellent distribution and encapsulation of the inorganic NPs along the NFs, but also allows to control and change the concentration, size, and type of the inorganic NPs without altering the NFs size, a fact that is not possible by conventional solution electrospinning. As proof of concept, NFs with up to three different types of inorganic NPs have been created in a single electrospinning step, but this technology allows to incorporate as much inorganic NPs as desired without altering the NFs morphology and ensuring a good distribution and encapsulation of the NPs. This paper demonstrates that green electrospinning is a powerful and attractive technology to create multifunctional NFs that are promising materials for sensing and biomedical applications.
Morus alba derived Kuwanon‐A combined with 5‐fluorouracil reduce tumor progression via synergistic activation of GADD153 in gastric cancer
Authors: Su Jingjing , Thakur Abhimanyu , Pan Guangzhao , Yan Jianglong , Gaurav Isha , Thakur Sudha , Yang Zhijun , Cili Alma , Zhang Kui 
Published: February 2023

AbstractDespite the application of conventional strategies including chemotherapy, radiotherapy, surgery, or immunotherapy, the mortality of gastric cancer (GC) patients remains high. Often, GC is not diagnosed until it has reached late stage, resulting in a missed surgical window. Therefore, a new therapeutic intervention for GC is necessary. Here, the combined application of Kuwanon‐A (KA) and 5‐fluorouracil (5‐FU) was evaluated for its potential to combat GC for the first time. To determine the anticancer activity of KA (from Morus alba) along with 5‐FU against GC, and their mechanism via GADD153, we examained anticancer potential of KA along with 5‐FU via in vitro assays with GC cells, namely MKN‐45, SGC‐7901, HGC‐27, and BGC‐823, and in vivo assays with mouse xenograft of GC. KA alone could induce G2/M phase arrest and apoptosis in GC cells by activating GADD153 through the PERK/elF2α/ATF4 and IRE1/XBP1 signaling pathways, suggesting a critical role of increased endoplasmic reticulum stress in KA‐induced apoptosis of GC cells. Moreover, the combination of KA and 5‐FU showed an enhanced synergistic anticancer effect against GC both in vitro and in vivo. Conclusively, the combination of KA and 5‐FU can act as an effective anticancer regimen in combating GC.
Modeling of the Copolymerization of Propylene with 1‐Hexene to Predict the Copolymer Molecular Weight and Composition
Authors: Herrero Franco , Brandolin Adriana , Sarmoria Claudia , Asteasuain Mariano 
Published: February 2023

AbstractA detailed mathematical model of the propylene‐1‐hexene copolymerization based on the two‐dimensional probability generation function technique is developed. It calculates the joint molecular weight‐copolymer composition distribution (MWD‐CCD) of the copolymer, as well as the average copolymer composition distribution, the molecular weight distribution (MWD), the copolymer composition distribution (CCD), average molecular weights and composition, and yield. The parallelized execution of the model code allows for obtaining the different copolymer microstructure distributions efficiently. The model allows for reaching a thorough understanding of the copolymer microstructure under different operating conditions of a semibatch reactor. It also has the potential to become a powerful tool for selecting operating conditions to obtain a material with target molecular properties.
Voiding dynamics of pelvic organ prolapse: Large scale comparative study
Authors: Çetinel Bülent , Kırlı Elif A. , Önal Bülent , Kalender Göktuğ , Demirbilek Muhammet , Okur Alper , Can Günay 
Published: February 2023

AbstractPurposeTo determine the voiding dynamics of the patients with pelvic organ prolapse (POP).Materials and methodsA retrospective patient file review was performed of 877 female patients with lower urinary tract symptoms. After exclusion criteria 373 female patients were eligible for the study. Two patient groups w/wo prolapse were identified. The symptoms, patient characteristics, patterns of free urine flow, and detrusor voiding pressure curves were compared between two groups. A comparison of the urodynamic findings between the subgroups (mild/moderate, severe, and w/o prolapse) was made and shown on a scatter plot graphics of PdetQmax versus Qmax as well.ResultsA total of 373 patients with median age 54 (18–92), 189 (51%) had varying degrees and forms of POP while 184 (49%) did not have any prolapse (p < 0.003). Logistic regression analysis results showed that older age [p = 0.023, odds ratio (OR) = 1.01, confidence interval (CI): (1.00–1.03)], weaker pelvic floor muscle strength [p = 0.032, OR = 1.67, CI: (1.04–2.69)], more frequent symptom of hesitancy [p = 0.003 OR = 2.15 CI: (1.29–3.58)], prolonged‐tailed shaped curve pattern of free urine flow [p = 0.027 OR = 1.97 CI: (1.08–3.58)], and higher PdetQmax (22 cmH2O) values [p = 0.002, OR = 1.02, CI: (1.00–1.03)] were the independent different features of the patients with prolapse. Subgroup urodynamic analysis showed significantly lower free flowmetry Qmax and higher PdetQmax values in patients with severe prolapse. Prolonged/tailed‐shaped curve pattern of free urine flow was significantly more frequent in patients with prolapse.ConclusionsVoiding dynamics of the patients with prolapse were significantly different from the patients' w/o prolapse. They had higher PdetQmax values, more frequent symptom of hesitancy, and prolonged shaped free flow curve pattern. Free flow Qmax values were lower in patients with severe prolapse.
Artificial instabilities of finite elements for nonlinear elasticity: Analysis and remedies
Authors: Bieber Simon , Auricchio Ferdinando , Reali Alessandro , Bischoff Manfred 
Published: February 2023

SummaryWithin the framework of plane strain nonlinear elasticity, we present a discussion on the stability properties of various Enhanced Assumed Strain (EAS) finite element formulations with respect to physical and artificial (hourglassing) instabilities. By means of a linearized buckling analysis we analyze the influence of element formulations on the geometric stiffness and provide new mechanical insights into the hourglassing phenomenon. Based on these findings, a simple strategy to avoid hourglassing for compression problems is proposed. It is based on a modification of the discrete Green‐Lagrange strain, simple to implement and generally applicable. The stabilization concept is tested for various popular element formulations (namely EAS elements and the assumed stress element by Pian and Sumihara). A further aspect of the present contribution is a discussion on proper benchmarking of finite elements in the context of hourglassing. We propose a simple bifurcation problem for which analytical solutions are readily available in the literature. It is tailored for an in‐depth stability analysis of finite elements and allows a reliable assessment of its stability properties.
Reducing ageism combining ageing education with clinical practice: A prospective cohort study in health sciences students
Authors: San‐Martín‐Gamboa Batirtze , Zarrazquin Idoia , Fernandez‐Atutxa Ainhoa , Cepeda‐Miguel Silvia , Doncel‐García Borja , Imaz‐Aramburu Idoia , Irazusta Amaia , Fraile‐Bermúdez Ana B. 
Published: February 2023

AbstractAimTo analyse the impact of an intervention combining ageing education with clinical practice in nursing homes on a nursing cohort's negative stereotypes and prejudices towards ageing.DesignA prospective cohort study was conducted in September 2019–October 2020 in a population of health sciences students (n = 222).MethodsQuestionnaire of Negative Stereotypes towards Aging (CENVE) and Aging Semantic Differential (DSE) were used to examine negative stereotypes and prejudices towards ageing in the nursing cohort exposed to the ageing education and practice intervention compared to a medical cohort that received no intervention. Group‐by‐time interaction, controlled by sex and age, for the effect of the intervention on CENVE and DSE scores was determined by mixed‐design ANOVA.ResultsThe nursing cohort significantly reduced negative stereotypes and prejudices towards ageing when compared to the medical cohort in total (F = 26.926; p < 0.001), health factor (F = 16.812; p < 0.001), motivational and social factor (F = 11.266; p = 0.001), and character and personality factor (F = 19.202; p < 0.001) scores of CENVE scale and in DSE (F = 7.826; p = 0.006).
Testing the guidelines of the New Coimbra Method for recording entheseal changes via interobserver agreement in a Bronze Age skeletal sample from Kültepe‐Kanesh, Türkiye
Authors: Kale Donald , Üstündağ Handan , Özen Semih , Özgü Doruk Cafer 
Published: February 2023

AbstractThe New Coimbra Method is the most recently proposed standardized method to assess entheseal changes (EC). However, the method's developers acknowledge the inadequacy of their guidelines and state that those who will use the method need in‐person training from them. This study aims to determine the applicability of the method's guideline by testing the interobserver agreement (IOA) with observers who were not trained by the developers. The second objective of this study is to apply the New Coimbra Method to a relatively small archeological sample, in this case a Bronze Age population from Kültepe‐Kanesh, Türkiye. Four observers (the authors) scored EC in three entheses of the right upper limb of 52 adults. IOA was analyzed via Fleiss' kappa (FK) and percentage of agreement (PA) tests. FK test results indicate moderate overall agreement (0.458), while PA implies significantly high agreement (95%). The results of the FK and PA tests contradict each other due to the known limitations of the latter. However, FK values among features vary broadly; some of the features indicate substantial agreement and surpass the required benchmark, while the rest remains moderate or lower. The features that revealed substantial agreement indicate the sufficiency of the method's guidelines. However, the guidelines for the other features appear to be inadequate. Further revision of the guidelines could make the method more applicable for all researchers with no requirement of in‐person training.
Self‐assembly of side‐chain liquid crystalline block copolymers to anisotropic polymeric nanoparticles
Authors: Sun Yalan , Deng Zichao , Chen Aihua 
Published: February 2023

AbstractAnisotropic polymeric nanoparticles (NPs) have attracted considerable attention due to their morphology‐dependent applications in the fields of nanocatalysts, drug delivery and sensors. By introducing liquid crystalline (LC) driving force into NPs, the region of non‐spherical shapes in phase diagrams can be broadened effectively, which attracts great interest of many researchers. LC mesogens can be easily introduced to monomers, such as acrylates and methacrylates, as side groups connected by spacers with tunable length, and then side‐chain LC polymers can be acquired after polymerization accordingly. Among these polymers, amphiphilic block copolymers (BCPs) have been widely studied, attributed to their property of spontaneous assembly into NPs under appropriate conditions. In this review, based on traditional solution self‐assembly and polymerization‐induced self‐assembly, the recent research into side‐chain LC BCP NPs is elaborated in terms of the aspects of the types of LC mesogens, LC phases, morphologies and functionalities. Finally, we summarize recent progress, and prospect the development trend in the future. © 2023 Society of Industrial Chemistry.
Rational design of stimuli‐responsive magnetic polymer hybrid (nano)materials
Authors: Nguyen Thi Phuong Thu , Ménager Christine , Rieger Jutta , Coumes Fanny 
Published: February 2023

AbstractCombining organic and inorganic materials is a fascinating strategy to produce hybrid materials that combine the advantages of both polymeric and inorganic materials. Among the various types of organic–inorganic hybrids, stimuli‐responsive magnetic polymer hybrids (RMPHs) are particularly promising materials for a wide variety of applications. While the magnetic properties are generally provided by the presence of magnetic nanoparticles, such as iron oxide nanoparticles, the polymeric compound brings the stimuli‐responsiveness, e.g. responsiveness to pH, temperature, redox reaction or irradiation. Furthermore, as the chemical structure and architecture of the polymeric materials are diverse and easily tunable, stimuli‐RMPHs have found applications in various domains, including catalysis, biotechnology, (bio)imaging and cancer therapy. Given the importance of the hybrids' shape and morphology for the targeted application, this review presents the possible synthetic strategies to rationally design stimuli‐RMPHs of various morphologies ranging from nanometric core–shell structures to nanogels, microgels and membranes. © 2023 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.
Exploring the polysaccharide composition of plant cell walls in succulent aloes
Authors: Isager Ahl Louise , Pedersen Henriette L. , Jørgensen Bodil , Willats William G. T. , Grace Olwen M. , Barnes Christopher J. , Rønsted Nina 
Published: February 2023

Societal Impact StatementAloes are iconic succulent plants native to Africa, Madagascar and the Arabian Peninsula. The succulent leaf mesophyll of aloes has been used extensively as a herbal product for centuries, contributing to their overexploitation. Health benefits are attributed to their polysaccharide content. We present a comprehensive comparison of the polysaccharide composition of succulent tissues from 93 Aloe species. We found polysaccharide composition primarily related to leaf morphology in alignment with the broad range of Aloe species used medicinally. All aloes except Aloe ferox and Aloe vera are endangered raising concern about over‐harvesting of wild species.Summary

Aloes are iconic succulent plants native to Africa, Madagascar and the Arabian Peninsula. All aloes except the commercially grown Aloe ferox and Aloe vera are protected according to the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Major factors contributing to their over‐exploitation are their ornamental value and medicinal use with more than 25% of Aloe species being utilised. The succulent inner leaf mesophyll of aloes is used in traditional medicine, with the healing effect ascribed to the properties of their structural polysaccharides.
To explore the correlation between Aloe polysaccharide profiles and other biologically relevant traits across the genus, we (1) extracted polysaccharides and created profiles for nearly 100 representative species using carbohydrate microarrays and molecular probes. We targeted six major plant cell wall polysaccharide groups using 27 different molecular probes. We (2) tested for phylogenetic signal in the polysaccharide profiles and (3) assembled an exhaustive database from literature on the geographic region, level of endemism, altitude, habitat, habit, medicinal use and leaf morphology of the individual species of Aloe.
In the absence of phylogenetic signal of polysaccharide profiles, multivariate linear modelling without phylogenetic correction was used and showed that polysaccharide composition primarily correlated with leaf morphology, highlighting the fundamental role of polysaccharides as the building blocks of plants. No correlations between polysaccharide composition of commercial and non‐commercial species were found.
We found polysaccharide composition to primarily relate to leaf morphology emphasising the fundamental and structural role of polysaccharides.
Physiologically based pharmacokinetic modeling of tacrolimus for food–drug and CYP3A drug–drug–gene interaction predictions
Authors: Loer Helena Leonie Hanae , Feick Denise , Rüdesheim Simeon , Selzer Dominik , Schwab Matthias , Teutonico Donato , Frechen Sebastian , van der Lee Maaike , Moes Dirk Jan A. R. , Swen Jesse J. , Lehr Thorsten 
Published: February 2023

AbstractThe immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying causes include the effect of food intake on tacrolimus absorption as well as genetic polymorphism in the CYP3A5 gene. Furthermore, tacrolimus is highly susceptible to drug–drug interactions, acting as a victim drug when coadministered with CYP3A perpetrators. This work describes the development of a whole‐body physiologically based pharmacokinetic model for tacrolimus as well as its application for investigation and prediction of (i) the impact of food intake on tacrolimus PK (food–drug interactions [FDIs]) and (ii) drug–drug(−gene) interactions (DD[G]Is) involving the CYP3A perpetrator drugs voriconazole, itraconazole, and rifampicin. The model was built in PK‐Sim® Version 10 using a total of 37 whole blood concentration–time profiles of tacrolimus (training and test) compiled from 911 healthy individuals covering the administration of tacrolimus as intravenous infusions as well as immediate‐release and extended‐release capsules. Metabolism was incorporated via CYP3A4 and CYP3A5, with varying activities implemented for different CYP3A5 genotypes and study populations. The good predictive model performance is demonstrated for the examined food effect studies with 6/6 predicted FDI area under the curve determined between first and last concentration measurements (AUClast) and 6/6 predicted FDI maximum whole blood concentration (Cmax) ratios within twofold of the respective observed ratios. In addition, 7/7 predicted DD(G)I AUClast and 6/7 predicted DD(G)I Cmax ratios were within twofold of their observed values. Potential applications of the final model include model‐informed drug discovery and development or the support of model‐informed precision dosing.
E‐Bayesian estimation for the parameters and hazard function of Gompertz distribution based on progressively type‐II right censoring with application
Authors: Mohie El‐Din Marwa M. , Sharawy Ali , Abu‐Moussa Mahmoud H. 
Published: February 2023

AbstractE‐Bayesian inference is of incremental significance in the area related to the reliability of industrial products dealing with censored data sets. In this article, based on the progressive Type‐II right censored order statistics (PTIIRCOS), the E‐Bayesian estimates (E‐BE) for the parameters of Gompertz distribution (GD) and its hazard function are obtained and compared with the maximum likelihood (MLE) and Bayesian (BE) estimates. The squared error loss function (SE), linear‐exponential loss function (LINEX), and Al‐Bayyati loss function (ALB) are considered for the methods of BE and E‐BE. Some properties for the E‐BE estimates are discussed based on PTIIRCOS. Real data is established to clear the theoretical procedures. Akaike information criterion (AIC) is used to prove that GD is the best to model the data compared to other competitors and could potentially be very adequate in describing and modeling industrial products data. Finally, simulation study has been operated for comparing the E‐BEs with the MLEs and BEs.
The combined addition of citric and aromatic organic acids to an acid soil prolongs phosphorus availability
Authors: Rahman Md. Shahinur , Schefe Cassandra , Weatherley Anthony 
Published: February 2023

AbstractThe role of organic acids (both aliphatic and aromatic) in increasing soil P availability is well established. However, the effect of the combined addition of aliphatic and aromatic organic acids on soil P availability is not well studied, which is particularly important when assessing the efficacy of heterogeneous natural organic acid sources, such as compost and biochar, on soil P availability based on their total abundance of organic acid compounds. In this study, some naturally occurring aliphatic (oxalic and citric) and aromatic (benzoic, 4‐hydroxybenzoic, and protocatechuic) organic acids were incubated with an acidic soil for up to 110 days and their effect on soil P availability (Olsen extractable P) and phosphorus buffering capacity (PBC) were studied. The aliphatic and aromatic organic acids were added as individual and combined treatments. The experimental results suggested that aliphatic organic acids were more effective in increasing Olsen extractable P and decreasing soil PBC when compared to aromatic organic acids. The effect of citric acid on increasing soil P availability was prolonged when applied in combination with aromatic organic acids. The contrasting chemical nature and complementary effect between aliphatic and aromatic organic acids were suggested as the reason for this phenomenon.