bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the impact of prior COVID‐19 on IgG antibody and interferon γ responses after BBIBP‐CorV vaccination in a disease endemic population: A prospective observational study
Authors: Hasan Zahra , Masood Kiran Iqbal , Qaiser Shama , Khan Erum , Hussain Areeba , Ghous Zara , Khan Unab , Yameen Maliha , Hassan Imran , Nasir Muhammad Imran , Qazi Muhammad Farrukh , Memon Haris Ali , Ali Shiza , Baloch Sadaf , Bhutta Zulfiqar A. , Veldhoen Marc , Pedro Simas J. , Mahmood Syed Faisal , Ghias Kulsoom , Hussain Rabia 
Published: September 2023

AbstractBackground and AimsCOVID‐19 vaccinations have reduced morbidity and mortality from the disease. Antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) have been associated with immune protection. Seroprevalence studies revealed high immunoglobulin G (IgG) antibody levels to SARS‐CoV‐2 in the Pakistani population before vaccinations. We investigated the effect of BBIBP‐CorV vaccination on circulating IgG antibodies and interferon (IFN)‐γ from T cells measured in a cohort of healthy individuals, with respect to age, gender, and history of COVID‐19.MethodsThe study was conducted between April and October 2021. BBIBP‐CorV vaccinated participants were followed up to 24 weeks. Antibodies to SARS‐CoV‐2 Spike protein and its receptor‐binding domain (RBD) were measured. IFNγ secreted by whole blood stimulation of Spike protein and extended genome antigens was determined.ResultsStudy participants with a history of prior COVID‐19 displayed a higher magnitude of IgG antibodies to Spike and RBD. IgG seropositivity was greater in those with prior COVID‐19, aged 50 years or younger and in females. At 24 weeks after vaccination, 37.4% of participants showed IFN‐γ responses to SARS‐CoV‐2 antigens. T cell IFN‐γ release was higher in those with prior COVID‐19 and those aged 50 years or less. Highest IFN‐γ release was observed to extended genome antigens in individuals both with and without prior COVID‐19.ConclusionWe found that IgG seropositivity to both Spike and RBD was affected by prior COVID‐19, age and gender. Importantly, seropositive responses persisted up to 24 weeks after vaccination. Persistence of vaccine induced IgG antibodies may be linked to the high seroprevalence observed earlier in unvaccinated individuals. Increased T cell reactivity to Spike and extended genome antigens reflects cellular activation induced by BBIBP‐CorV. COVID‐19 vaccination may have longer lasting immune responses in populations with a higher seroprevalence. These data inform on vaccination booster policies for high‐risk groups.
Cultural brokering in pregnancy care: A critical review
Authors: DiMeo Amanda , Karlage Ami , Schoenherr Karen , Spigel Lauren , Chakraborty Saugata , Bazan Maria , Molina Rose L. 
Published: September 2023

AbstractPeople who speak languages other than English face structural barriers in accessing the US healthcare system. With a growing number of people living in countries other than their countries of birth, the impact of language and cultural differences between patients and care teams on quality care is global. Cultural brokering presents a unique opportunity to enhance communication and trust between patients and clinicians from different cultural backgrounds during pregnancy care—a critical window for engaging families in the healthcare system. This critical review aims to synthesize literature describing cultural brokering in pregnancy care. We searched keywords relating to cultural brokering, pregnancy, and language in PubMed, Embase, and CINAHL and traced references of screened articles. Our search identified 33 articles. We found that cultural brokering is not clearly defined in the current literature. Few of the articles provided information about language concordance between cultural brokers and patients or clinicians. No article described the impact of cultural brokering on health outcomes. Facilitators of cultural brokering included: interprofessional collaboration within the care team, feeling a family connection between the cultural broker and patients, and cultivating trust between the cultural broker and clinicians. Barriers to cultural brokering included: misunderstanding the responsibilities, difficulty maintaining personal boundaries, and limited availability and accessibility of cultural brokers. We propose cultural brokering as interactions that cover four key aims: (1) language support; (2) bridging cultural differences; (3) social support and advocacy; and (4) navigation of the healthcare system. Clinicians, researchers, and policymakers should develop consistent language around cultural brokering in pregnancy care and examine the impact of cultural brokers on health outcomes.
Segmentation and classification of medical big data on brain tumor using bacteria foraging optimization algorithm along with learning automata
Authors: Keerthi Devarahatty Shivakumar , Maithri Chandrashekhar , Dayanidhi Mohapatra , Kavitha Malali Vishveshwarappa Gowda , Ananda Babu Jayachandra 
Published: September 2023

AbstractDetecting the early stage of brain tumors is significant for an effective therapy that can probably minimize the death rate of patients affected from brain tumors. Magnetic resonance imaging is the benchmark standard for diagnosing brain cancers but, it was difficult to split and categorize different kinds of brain tumors due to the delicate arrangement of the brain's anatomy. To overcome these difficulties and provide an effective classification, this research introduced a hybridized optimization technique which enhance the performance of the classifier. The hybridization is done between Bacteria Foraging Optimization Algorithm (BFOA) along with Learning Automata (LA), these two techniques improve the search speed and automate the learning capability of Convolutional Neural Network (CNN) classifier. The obtained results show that proposed BFOA LN‐CNN classifier better than the existing Deep Convolutional Neural Network (DCNN) based on Improved Harris Hawks Optimization (HHO) known as G‐HHO and Improved Invasive Bat (IIB)‐based Deep Residual network model. The classification accuracy of the proposed method is 99.41% whereas the DCNN‐G‐HHO and IIB deep residual neural network provides accuracy of 97% and 91.9% respectively.
Effect of unsoluble corrosion products of WE43 alloys in vitro on macrophages
Authors: Dong Li , Shen Zhiyuan , Zhang Huidi , Zhang Binmei , Zhou Yinze , Lv Xin , Hong Xiaojian , Liu Jiaren , Yang Wei 
Published: September 2023

AbstractMagnesium alloys have been used to manufacture biodegradable implants, bone graft substitutes, and cardiovascular stents. WE43 was the most widely used magnesium alloy. The degradation process begins when the magnesium alloy stent is implanted in the body and comes into contact with body fluid. The degradation products include hydrogen, Mg2+, local alkaline environment, and unsoluble products. A large number of studies focused on Mg2+ and pH in vitro, and in vivo of magnesium alloys, but few studies on unsoluble corrosion products (UCPs). In this study, UCPs of WE43 alloy were prepared by immersion in vitro, and their effects on macrophages were investigated. The results showed that the unsoluble corrosion products were Mg24Y5, Mg12YNd, and MgCO3·3H2O, which were dose‐dependent on the apoptosis and necrosis of macrophages. After phagocytosis of UCPs, macrophages mainly metabolize in lysosome, and autophagy also participates in the metabolism of UCPs. It also decreases mitochondrial membrane potential and increases lysosomes, endoplasmic reticulum stress, and P2X7 receptor activation. These will increase reactive oxygen species (ROS) in cells, activating NLRP3 inflammatory corpuscles, activating the downstream pro‐IL18 and pro‐IL1β, and converting it to IL‐18, and IL‐1β. However, its pro‐inflammatory effect is far lower than that of the classical Lipopolysaccharide (LPS) pro‐inflammatory pathway. This work has increased our understanding of magnesium alloy metabolism and provides new ideas for the clinical application of magnesium alloys.
Mesenchymal stem cells and ovarian cancer: Is there promising news?
Authors: Jahani Saleheh , Zare Nabi , Mirzaei Yousef , Arefnezhad Reza , Zarei Hooman , Goleij Pouya , Bagheri Nader 
Published: September 2023

AbstractOvarian cancer (OC) is described as a heterogeneous complex condition with high mortality, weak prognosis, and late‐stage presentation. OC has several subgroups based on different indices, like the origin and histopathology. The current treatments against OC include surgery followed by chemotherapy and radiotherapy; however, these methods have represented diverse side effects without enough effectiveness on OC. Recently, mesenchymal stem cell (MSC)‐based therapy has acquired particular attention for treating diverse problems, such as cancer. These multipotent stem cells can be obtained from different sources, such as the umbilical cord, adipose tissues, bone marrow, and placenta, and their efficacy has been investigated against OC. Hence, in this narrative review, we aimed to review and discuss the present studies about the effects of various sources of MSCs on OC with a special focus on involved mechanisms.
Oncogenic miR‐1825 promotes head and neck carcinogenesis via targeting FREM1
Authors: Capik Ozel , Gundogdu Betul , Tatar Arzu , Sahin Abdulkadir , Chen Fengju , Creighton Chad J. , Karatas Omer Faruk 
Published: September 2023

AbstractHead and neck squamous cell carcinoma (HNSCC) is the sixth most common malignant cancer type worldwide. Although the therapeutic modalities currently used for patients with HNSCC improved in recent decades, HNSCC prognosis is still poor. Therefore, it is an urgent necessity to understand the pathogenesis of HNSCC, to develop novel and effective treatment strategies, and to characterize and identify the oncogenes that are responsible for an aggressive HNSCC phenotype. In this study, we aimed to better understand the roles of miR‐1825 in the pathogenesis of HNSCC. We examined the impacts of miR‐1825 deregulation on the cancer‐associated phenotypes using in vitro tests evaluating cell viability, clonogenicity, cell migration, invasion, apoptosis, and stem cell characteristics. In addition, we investigated the effects of miR‐1825 overexpression on the tumor formation capacity of head and neck cancer cells in vivo using nude mice. We searched for potential targets of miR‐1825 using microarray analysis and luciferase assay. We found that miR‐1825 expression is upregulated in head and neck cells and clinical tumor samples in comparison to corresponding controls, where it potentially acts as an oncogene. We, then, showed that ectopic miR‐1825 overexpression promotes cellular phenotypes related to head and neck cancer progression in vitro and has a stimulating potential on cancer formation in vivo. We also identified FREM1 as a direct target of miR‐1825 and demonstrated its reduced expression in HNSCC samples using immunohistochemistry analysis. Collectively, we suggest that the miR‐1825/FREM1 axis serves as an important mediator of HNSCC development, where miR‐1825 acts as an oncogene.
β‐catenin inhibitor ICG‐001 suppress cell cycle progression and induce autophagy in endometrial cancer cells
Authors: Hsin I‐Lun , Wu Pei‐Ju , Tang Sheau‐Chung , Ou Chu‐Chyn , Chang Hui‐Yi , Shen Huang‐Pin , Ko Jiunn‐Liang , Wang Po‐Hui 
Published: September 2023

AbstractThe incidence of endometrial cancer has been rising in recent years. Gene mutation and high protein expression of β‐catenin are commonly detected in endometrioid endometrial cancer. ICG‐001 is a β‐catenin inhibitor via blocking the complex formation of β‐catenin and cAMP response element‐binding protein (CREB)‐binding protein (CBP). This study aims to investigate the effect of ICG‐001 on endometrial cancer inhibition. First, endometrial carcinoma patient‐derived xenograft (PDX)‐derived organoids and primary cells were used to verify the inhibiting ability of ICG‐001 on endometrial cancer. Furthermore, endometrial cancer cell lines were used to investigate the anticancer mechanism of ICG‐001. Using MTT assay and tumor spheroid formation assay, ICG‐001 significantly reduced the cell viability of HEC‐59 and HEC‐1A cells. ICG‐001 enhanced cisplatin‐mediated cytotoxicity. ICG‐001 decreased cancer stem cell sphere formation. ICG‐001 decreased the protein expressions of CD44, hexokinase 2 (HK2), and cyclin A. ICG‐001 lowered the cell cycle progression by flow cytometer analysis. Autophagy, but no apoptosis, was activated by ICG‐001 in endometrial cancer cells. Autophagy inhibition by ATG5 silencing enhanced ICG‐001‐mediated suppression of cell viability, tumor spheroid formation, and protein expression of cyclin A and CD44. This study clarified the mechanism and revealed the clinical potential of ICG‐001 against endometrial cancer.
Research progress on the regulation of bone marrow stem cells by noncoding RNAs in adolescent idiopathic scoliosis
Authors: Li Meng‐Jun , Liang Zhuo‐Tao , Sun Yang , Li Jiong , Zhang Hong‐Qi , Deng Ang 
Published: September 2023

AbstractAdolescent idiopathic scoliosis (AIS) is a common spinal deformity in young women, but its pathogenesis remains unclear. The primary pathogenic factors contributing to its development include genetics, abnormal bone metabolism, and endocrine factors. Bone marrow stem cells (BMSCs) play a crucial role in the pathogenesis of AIS by regulating its occurrence and progression. Noncoding RNAs (ncRNAs) are also involved in the pathogenesis of AIS, and their role in regulating BMSCs in patients with AIS requires further evaluation. In this review, we discuss the relevant literature regarding the osteogenic, chondrogenic, and lipogenic differentiation of BMSCs. The corresponding mechanisms of ncRNA‐mediated BMSC regulation in patients with AIS, recent advancements in AIS and ncRNA research, and the importance of ncRNA translation profiling and multiomics are highlighted.
Effects of drinking water treatment residual amendments to biosolids on plant uptake of per‐ and polyfluoroalkyl substances
Authors: Broadbent Emma , Gravesen Caleb , Choi Youn Jeong , Lee Linda , Wilson Patrick C. , Judy Jonathan D. 
Published: September 2023

AbstractDrinking water treatment residuals (DWTRs), solid by‐products of drinking water treatment, are dominated by calcium (Ca), iron (Fe), or aluminum (Al), depending on the coagulant used. DWTRs are often landfilled, but current research is exploring options for beneficial reuse. Previous studies have shown that Al‐ and Fe‐rich materials have potential to reduce the mobility of per‐ and polyfluoroalkyl substances (PFAS). Here, we investigated how amending biosolids with 5% wt/wt DWTRs affected plant bioavailable PFAS in two different simulated scenarios: (1) agricultural scenario with Solanum lycopersicum (tomato) grown in soil amended with an agronomically relevant rate of DWTR‐amended biosolids (0.9% w/w, resulting in 0.045% w/w DWTR in the biosolids‐amended soil) and (2) mine reclamation scenario examining PFAS uptake by Lolium perenne (perennial ryegrass) grown in soil that received DWTR‐amended biosolids amendment at a rate consistent with the mine remediation (13% w/w, resulting in 0.65% w/w DWTR in the biosolids‐amended soil). Amending biosolids with Ca‐DWTR significantly reduced perfluorobutanoic acid (PFBA) uptake in ryegrass and perfluorohexanoic acid uptake in tomatoes, possibly due to DWTR‐induced pH elevation, while Fe‐DWTR amendment reduced PFBA bioaccumulation in ryegrass. The Al‐DWTR did not induce a significant reduction in accumulated PFAS compared to controls. Although the reasons for this finding are unclear, the relatively low PFAS concentrations in the biosolids and relatively high Al content in the biosolids and soil may be partially responsible.
Low‐dose gemcitabine plus nab‐paclitaxel versus standard‐dose gemcitabine plus nab‐paclitaxel in elderly patients with metastatic pancreatic cancer: A randomized Phase II trial
Authors: Kamata Ken , Imai Hajime , Matsumoto Hisakazu , Yamashita Yukitaka , Kato Takao , Nishi Katsuhisa , Omoto Shunsuke , Minaga Kosuke , Yamao Kentaro , Hyodo Tomoko , Im Sung‐Woon , Hara Akane , Yoshikawa Tomoe , Ishikawa Rei , Okamoto Ayana , Yamazaki Tomohiro , Nakai Atsushi , Ueshima Kazuomi , Chiba Yasutaka , Takenaka Mamoru , Watanabe Tomohiro , Kitano Masayuki , Kudo Masatoshi 
Published: September 2023

AbstractBackground and AimA multicenter, open‐label randomized Phase II trial was conducted to determine whether low‐dose gemcitabine plus nab‐paclitaxel (GnP) could improve tolerability and show equivalent efficacy to the standard‐dose GnP for elderly patients with metastatic pancreatic cancer.MethodsConsecutive patients aged ≥65 years with metastatic pancreatic cancer who presented at one of four Japanese referral centers between November 2016 and January 2021 were enrolled. The 60 patients were randomly assigned to low‐ or standard‐dose groups with a 1:1 ratio. Patients in the low‐dose GnP group received gemcitabine at a dose of 250 mg/m2 and nab‐paclitaxel at 125 mg/m2.ResultsLow‐dose GnP significantly decreased the rate of cases requiring dose reduction (16.7% vs 63.3%). The response rate (36.7% vs 33.3%) and progression‐free survival (7.3 vs 8 months) were comparable between the low‐ and standard‐dose groups as determined by independent review. The difference in the median overall survival between the two groups was not significant (7.9 vs 12 months). The proportion of patients with hematologic and non‐hematologic treatment‐related adverse events was comparable between the two groups.ConclusionLow‐dose GnP had an equivalent efficacy to conventional therapy; however, it did not reduce adverse events.
Patterns description of hyperostosis observed in Atlantic moonfish Selene setapinnis and lookdown Selene vomer
Authors: Tuna Fernando A. P. , Calixto Flávia A. A. , Luz Marcelline , Mesquita Eliana F. M. 
Published: September 2023

AbstractHyperostosis manifests itself and develops differently in taxonomically related species. Radiographic images of individuals belonging to different size classes of Atlantic Moonfish Selene setapinnis and Lookdown Selene vomer were obtained from two different estuarine areas of Rio de Janeiro/Brazil. In S. setapinnis, hyperostosis occurred in 65.22% of the specimens analyzed in three different skeletal regions. All specimens of S. vomer had hyperostosis in four regions. Patterns of occurrence were detected in both species, and the affected regions did not coincide in the same bone region, except for the cleithrum. Hyperostosis in S. setapinnis were observed in high frequencies of seventh dorsal pterygiophore, whereas in specimens of S. vomer this condition was detected to a greater extent in the neural spines of the second abdominal vertebra and first to third caudal vertebrae. The data demonstrated a relationship between the sexual maturity and the occurrence and development of hyperostotic bones in ageing process of individuals. It is the first description of S. vomer with a hyperostosis phenomenon for the species on the Brazilian coast.
Value of Quantitative Susceptibility Mapping in Clinical Neuroradiology
Authors: Fushimi Yasutaka , Nakajima Satoshi , Sakata Akihiko , Okuchi Sachi , Otani Sayo , Nakamoto Yuji 
Published: September 2023

Quantitative susceptibility mapping (QSM) is a unique technique for providing quantitative information on tissue magnetic susceptibility using phase image data. QSM can provide valuable information regarding physiological and pathological processes such as iron deposition, hemorrhage, calcification, and myelin. QSM has been considered for use as an imaging biomarker to investigate physiological status and pathological changes. Although various studies have investigated the clinical applications of QSM, particularly regarding the use of QSM in clinical practice, have not been examined well. This review provides on an overview of the basics of QSM and its clinical applications in neuroradiology.Level of Evidence2Technical EfficacyStage 2
Sensitivity analysis of a layered piezoelectric system using ZFEM
Authors: Acosta Carlos , Bhalla Amar , Guo Ruyan 
Published: September 2023

AbstractThe complex variable finite element method (ZFEM) is a numerical technique which aims to find the partial derivatives of the independent variables with respect to variation in dependent parameters declared in the physics. This is done by combining the complex Taylor series expansion within the weak formulation of the governing equation in a coupled system of linear equations forming a complex valued block matrix given by the Cauchy–Riemann matrix representation. In this work, two‐dimensional linear first‐order elements have been implemented in ZFEM to predict the design derivatives of the mechanical displacement field and the voltage potential field for a layered piezoelectric system in a steady‐state study with Dirichlet boundary condition applied at the top and bottom edges of the geometry. This approach allows the standard FEM solution to quantify the sensitivity of the mechanical displacement and voltage potential fields with respect to small variations in the material properties through the information obtained from the computation of the derivatives. The domain is formed by a layered body with PZT‐4 and PZT‐5 stacked together. For result verification, the numerical solution obtained with ZFEM was compared to results from a commercial FEM package and the solution from the imaginary part was compared to the exact solution of a well‐known benchmark problem. Comparison of the results showed good agreement for both the real and imaginary parts of the solution and the largest sensitivities were found in PZT‐5 specifically in , , and .