bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Ro52 antibody is a risk factor for depression and anxiety in patients with connective tissue diseases: an observational, single-center, cross-sectional study
Authors: Yang Leilei , Wang Xiaoqin , Kang Haiyan , Gu Bingjie , Ren Qijie , Su Dinglei , Shen Minning 
Published: May 2023

Abstract
Background The risk of mental disorders such as depression and anxiety is increased in connective tissue diseases (CTDs). However, little is known about whether this risk is related to autoantibodies. We conducted an observational, single-center, cross-sectional study to investigate the correlation of depression and anxiety with the presence of autoantibodies in patients with CTDs.Methods Three hundred and fifty-two inpatients with CTDs were recruited and their demographic, serological and imaging data were collected through the medical record system. Depression and anxiety were assessed by the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 Scale (GAD-7) respectively. Analysis of variance (ANOVA), rank sum test, chi-square test and logistic regression were performed to investigate risk factors for depression and anxiety.Results The prevalence of depression (PHQ-9 ≥ 5) and anxiety (GAD-7 ≥ 5) in CTD patients was significantly higher than that in the Chinese general population (depression: 44.3% vs 32.2%, anxiety: 39.5% vs 22.2%). Sleep time was a protective factor for both depression and anxiety (OR = 0.719, 95% CI: 0.605 ~ 0.856, P = 0.0002 and OR = 0.639, 95% CI: 0.528 ~ 0.773, P < 0.0001, respectively) while anti-Ro52 antibody was a risk factor for them (OR = 5.545, 95% CI: 3.053 ~ 10.074, P < 0.001 and OR = 5.642, 95% CI: 3.071 ~ 10.363, P < 0.0001, respectively). Further analysis showed that anti-Ro52 antibody was a risk factor for depression and anxiety in all four subgroups, namely SLE, SS, RA, and other CTDs.Conclusion Anti-Ro52 antibody is a risk factor for depression and anxiety in patients with connective tissue diseases. CTD patients with the presence of anti-Ro52 antibody are more prone to depression and anxiety than those without it.
A comparison of the effects of Ketamine-Midazolam and Ketamine-Propofol combinations on vital signs of uncooperative children with dental diseases in a crossover study with repeated measurements: The Bayesian approach
Authors: Abbasi-Asl Tahereh , Zayeri Farid , Ghasemi Erfan , Ghajari Masoud Fallahinejad , Amiritehranizadeh Narjes , Meymeh Maryam Heydarpour , Baghban Alireza Akbarzadeh 
Published: May 2023

AbstractBackground:To calm non-cooperative children needing dental treatment, sedatives are used. Vital parameters must be monitored during sedation. This study aimed to evaluate the effects of Ketamine-Midazolam (KM) and Ketamine-Propofol (KP) combinations on the heart rate (HR) and oxygen saturation (SPO2) of uncooperative children. The model parameters were estimated using the Bayesian approach.Methods:The data were collected in a double-blind crossover study with repeated measurements (CSWRM). Twenty-two 3-6-year-old uncooperative children were included, and the linear mixed model was adopted for data analysis.Results:A significant difference of 4.47 beats per minute (bpm) was found in the mean HR of KM recipients compared to KP recipients. The mean HR in KP was lower than that of KM, but it did not make a difference in SPO2.Conclusions:Although there was no difference in the two drug combinations regarding SPO2, they differed in HR. As such, the KP combination is recommended. The study was registered in the Iranian Registry of Clinical Trials (IRCT20090506001882N10) at the date of 2021-03-08.
Primary gastrinoma of the gallbladder: a case report and review of the literature
Authors: Liu Yao-Ge , Jiang Shi-Tao , Zhou Yang , Zhang Jun-Wei , Sang Xin-Ting , Zhang Lei , Xu Yi-Yao , Lu Xin 
Published: May 2023

Abstract
Background: Primary gallbladder gastrinoma is an exceptionally uncommon tumor which is a rare form of neuroendocrine neoplasm. Until now, no cases of primary gallbladder gastrinoma and rare cases of primary gastrinoma from the biliary system have been reported.
Case presentation: We reported a 50-year-old female with watery diarrhea and intermittently received proton pump inhibitors as treatment. Enhanced computed tomography (CT) imaging and Octreotide imaging uncovered a solitary tumor at the hepatic hilar region. The tumor was found originated from the wall of the gallbladder during the surgery and a subsequent laparoscopic cholecystectomy was exerted. Histological analysis revealed a primary neuroendocrine tumor from the gallbaldder.
Conclusion: This case confirmed that primary gallbladder gastrinoma represents a distinct nosological entity. Immunohistochemical analysis plays a pivotal role in the diagnosis process. Due to limited knowledge regarding primary gallbladder gastrinoma, we aim to contribute valuable insights into this rare condition by providing unique information and present the therapeutic value of surgery.
Natural course of perianal abscess in infants: a Real-World Study
Authors: Yin Wanbin , Li Yansen , Zhang Jingfeng , Jiao Yang , Pei Wenju , Xu Xiangjun , Fan Mingfeng , Xu Juan , Zhou Yue , Wang Shuai , Wei Yanhua 
Published: May 2023

Abstract
OBJECTIVE:
Natural course of perianal abscess (PA) in infancy remains obscure. This study aimed to investigate the natural course of infants with PA after conservative treatment.
METHODS:
A retrospective cohort study was conducted in infants with PA who were treated conservatively, for more than 2 months between 2014 and 2020 at a single tertiary center.
RESTULTS:
153 patients (149 boys and 4 girls) were identified. The median follow-up was 5.3 years (range 3-8.2 years). Initially, 119 patients (77.8%) were completely cured by conservative treatment, and 34 (22.2%) failed (fistula formation, abscess recurrence, or new-onset abscess). Among the 34 patients, 23 continued conservative treatment (20 cure, 3 fistula formation) and 11 underwent surgery (incision and drainage or incision and drainage with fistulotomy). Overall, 139 patients (90.8%) were cured conservatively without surgery, and 11 (7.2%) underwent surgical management. In addition, 3 (2.0%) patients developed fistula-in-ano (under observation).
CONCLUSIONS:
PA in infants may be a time-limited and self-limited condition. Conservative management should be the first choice of treatment in most cases. Surgical management of PA in infants is indicated when conservative treatment fails.
Blue color of ribbontail stingray skin stems from a core-shell photonic glass ultrastructure
Authors: Surapaneni Venkata A , Blumer Michael J , Tadayon Kian , McIvor Ashlie , Redl Stefan , Honis Hanne-Rose , Mollen Frederik H. , Amini Shahrouz , Dean Mason N 
Published: May 2023

Abstract
Blue structural colors, produced by diverse tissue nanostructures, are known from all
major vertebrate clades except cartilaginous fishes (e.g. sharks, rays). We describe a
bright angle-independent structural blue from ribbontail stingray skin, arising from a
novel cell type with unique quasi-ordered arrays of nano-vesicles enclosing guanine
nanoplatelets. This natural architecture —an intracellular photonic glass— coherently
scatters blue, while broadband absorption from closely-associated melanophores
obviates the low color-saturation typical for photonic glasses. This first demonstration
of structural color in elasmobranchs (the oldest extant clade of jawed vertebrates)
illustrates that the capacity for guanine-based colors likely arose extremely early in
vertebrate evolution. The structure-function mechanisms underlying ribbontail stingray
coloration point to selective pressures driving elasmobranch visual ecology and
communication, but also strategies for biomimetic color production.
Statistical analysis of climate change over Hanumangarh district
Authors: Patel Shahid , Mehta Darshan 
Published: May 2023

Abstract

Precipitation is the most critical element of the hydrological cycle that might influence the frequency of floods or drought. Therefore, for drought and flood forecasting, knowing the precipitation pattern and its trend is mandatory. The research aims to estimate the monthly, seasonal, and annual precipitation trend using statistical (Mann Kendall test & Sen's Slope estimator) and graphical (Innovative Trend Analysis method) for the Hanumangarh district of N-E Rajasthan. The mean monthly precipitation data were gathered from the India-WRIS from 1901 to 2022 (122 years). Seasonal and annual precipitation trend variations were examined by statistical methods and compared with the graphical method. The study results conclude that precipitation trends showed variability for the SW monsoon season from the graphical to the statistical method. For the SW monsoon season, the decreasing trend was seen using statistical methods. In contrast, the graphical method revealed an increasing trend. During the annual precipitation, increasing trends were seen using statistical and graphical methods. It is found that the ITA method is more efficient in finding trends because it does not assume any assumptions like that of the MK test. This study will help water resources engineers and local people with sustainable management, planning, and development of water resources in the Hanumangarh district.
Performance of municipal waste stabilization ponds in the Saharan desert (Morocco)
Authors: Achag Badre , Mouhanni Hind , Bendou Abdelaziz 
Published: May 2023

Abstract
The majority of cities in the Saharan territory of south Morocco utilize waste stabilization ponds (WSPs) for municipal wastewater treatment because of their relatively low capital, operational costs, and minimal complexity. New national effluent quality regulations have been implemented in Morocco, and they will be applied to all treatment systems. In this study, we chose three cities that are located in the Saharan area characterized by an arid climate and water scarcity. They are facing the challenges of rapid urbanization and the need to improve wastewater treatment and management. Treatment performance is impacted by community water use, pond design, and climate. The performance evaluation concerns seven physicochemical parameters during the year 2020. Monitoring results showed that WSPs in this climate can achieve removal rates between 75% and 85% for organic pollution and total suspended matter, but were challenged to produce effluent quality that meets reuse standards. Performance and statistical analysis have been done and confirm the existence of correlations between these parameters and the climate of the region. For the improvement of the quality of these waters, it is legitimate to upgrade the three WSPs with a tertiary treatment with maturation ponds.
LINC00891 Promotes Tumorigenesis and Metastasis of Thyroid
Cancer by Regulating SMAD2/3 via EZH2
Authors: Si Yuhao , Wen Jialiang , Hu Chunlei , Chen Hao , Lin Lizhi , Xu Yiying , Ren Disuo , Meng Xinyu , Wang Yinghao , Xia Erjie , Bhandari Adheesh , Wang Ouchen 
Published: May 2023

Background:
Thyroid cancer (TC), the most common endocrine malignant tumor,
is increasingly causing a huge threat to our health nowadays.

Methods:
To explore the tumorigenesis mechanism of thyroid cancer, we identified that
long intergenic non-coding RNA-00891 (LINC00891) was upregulated in TC using the
Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and local databases.
LINC00891 expression was correlated with histological type and lymph node metastasis
(LNM). The high expression of LINC00891 could serve as a diagnostic marker for TC
and its LNM. In vitro experiments demonstrated that LINC00891 knockdown could inhibit
cell proliferation, migration, invasion and prompt apoptosis and G1 arrest of TC
cells. We also investigated the related mechanisms of LINC00891 promoting TC progression
using RNA sequencing, Gene Set Enrichment Analysis, and Western blotting.

Results:
Our experiments demonstrated that LINC00891 promoted TC progression via
the EZH2-SMAD2/3 signaling axis. In addition, overexpression of EZH2 could reverse
the suppressive epithelial-to-mesenchymal transition (EMT) caused by LINC00891
knockdown.

Conclusion:
In conclusion, the LINC00891/EZH2/SMAD2/3 regulatory axis participated
in tumorigenesis and metastasis of thyroid cancer, which may provide a novel target
for treatment.
Phytochemicals and Biological Activities of Pulicaria genus: Emphasis on the Flavonoids
and Sesquiterpenoids and Cytotoxicity Effects
Authors: Alamdary Marzieh Pourhossein , Baharfar Robabeh 
Published: May 2023

Abstract:
The use of herbal remedies is more current in illnesses with chronic diseases. One
of these important applications is the usage of many plant-derived compounds as cytotoxic
agents for the treatment of cancers. Various research has been done on several species of Pulicaria
genus for the evaluation of antihistaminic, antimicrobial, antitumor, antiinflammatory,
antioxidant, antibacterial, antifungal, insecticide, and leishmanicidal activities.
Some studies have shown that these plants have a rich pool of biometabolites like diterpenes,
sesquiterpenes, caryophyllenes, flavonoids, and sesquiterpenoids. The main components in
several species of this genus are flavonoids and sesquiterpenoids, which have been identified
in chemotaxonomic studies and have shown cytotoxic properties. The Scopus and Science
Direct sites were studied to find articles on flavonoid and sesquiterpenoid compounds that
have been isolated from the Pulicaria genus.

:
Several biological compounds were isolated from different species of the Pulicaria genus. The main compounds
are flavonoids and sesquiterpenoids, which have different biological effects. Its main effect is cytotoxic effect
against several cancer cell lines. This study indicates that the Pulicaria genus has cytotoxic activity but posterity
studies are needed to probe the active compounds and their possible expansion as novel anticancer drugs.
Phytochemical and Pharmacological Attributes of Nerium oleander: A Review
Authors: Pandey Amita , Usmani Shazia , Ahmad Mohd , Khatoon Shabana , Wahab Shadma , Prakash Om 
Published: May 2023

Background:Nerium Oleander is an Indian folk medicine popularly known as oleander, contains numerous phytoconstituents and nutritional agents for the treatment of multiple ailments.Objective:The prime objective for the current comprehensive review is to focus on the elaboration of phytochemistry along with the Pharmacological significance of N. oleander.Methods:As per literature investigations it was noticed that plant contains various phytochemical constituents, including Oleandric acid, Kaneroside, Cardenolide, Nerizoside, Neritaloside, Odoroside- H,3-Ocaffeoylquinic acid along with structural isomer, 5-Ocaffeoylquinic acid, α-tocopherol, Oleandrin, Digitoxgenin along with nutritional ingredients viz essential fatty acids like omega- 3 fatty acids, and other polyphenols reported in N. oleander.Results:In recent investigations, it was observed that oleander possesses a wide range of medicinal attributes viz. anti-inflammatory, larvicidal, anti-cancer, Antidiabetic, Cellular/humoral immune response, Hepatoprotective, Wound healing, Anti-microbial, Antioxidant, Antinociceptive, Locomotor, Diuretic, and Anti leukemic activities.Conclusion:N. oleander could be an excellent candidate for discovering new medications because of its wide range of pharmacological action and the large diversity of active phytochemicals. However, to disclose the favorable therapeutic, safety, and pharmacological virtues of N. oleander and its phytoconstituents, more clinical and experimental investigations are needed.
Global Misinformation Spillovers in the Vaccination Debate Before and During the COVID-19 Pandemic: Multilingual Twitter Study
Authors: Lenti Jacopo , Mejova Yelena , Kalimeri Kyriaki , Panisson André , Paolotti Daniela , Tizzani Michele , Starnini Michele 
Published: May 2023

Background
Antivaccination views pervade online social media, fueling distrust in scientific expertise and increasing the number of vaccine-hesitant individuals. Although previous studies focused on specific countries, the COVID-19 pandemic has brought the vaccination discourse worldwide, underpinning the need to tackle low-credible information flows on a global scale to design effective countermeasures.

Objective
This study aimed to quantify cross-border misinformation flows among users exposed to antivaccination (no-vax) content and the effects of content moderation on vaccine-related misinformation.

Methods
We collected 316 million vaccine-related Twitter (Twitter, Inc) messages in 18 languages from October 2019 to March 2021. We geolocated users in 28 different countries and reconstructed a retweet network and cosharing network for each country. We identified communities of users exposed to no-vax content by detecting communities in the retweet network via hierarchical clustering and manual annotation. We collected a list of low-credibility domains and quantified the interactions and misinformation flows among no-vax communities of different countries.

Results
The findings showed that during the pandemic, no-vax communities became more central in the country-specific debates and their cross-border connections strengthened, revealing a global Twitter antivaccination network. US users are central in this network, whereas Russian users also became net exporters of misinformation during vaccination rollout. Interestingly, we found that Twitter’s content moderation efforts, in particular the suspension of users following the January 6 US Capitol attack, had a worldwide impact in reducing the spread of misinformation about vaccines.

Conclusions
These findings may help public health institutions and social media platforms mitigate the spread of health-related, low-credibility information by revealing vulnerable web-based communities.
Ability of Black-Box Optimisation to Efficiently Perform Simulation Studies in Power Engineering
Authors: Peters Lukas , Kutzner Rüdiger , Schäfer Marc , Hofmann Lutz 
Published: May 2023

Abstract
In this study, the potential of the so-called black-box optimisation (BBO) to increase the efficiency of simulation studies in power engineering is evaluated. Three algorithms (“Multilevel Coordinate Search” (MCS) and “Stable Noisy Optimization by Branch and Fit” (SNOBFIT) by Huyer and Neumaier and “blackbox: A Procedure for Parallel Optimization of Expensive Black-box Functions” (blackbox) by Knysh and Korkolis) are implemented in MATLAB and compared for solving two use cases: the analysis of the maximum rotational speed of a gas turbine after a load rejection and the identification of transfer function parameters by measurements. The first use case has a high computational cost, whereas the second use case is computationally cheap. For each run of the algorithms, the accuracy of the found solution and the number of simulations or function evaluations needed to determine the optimum and the overall runtime are used to identify the potential of the algorithms in comparison to currently used methods. All methods provide solutions for potential optima that are at least 99.8% accurate compared to the reference methods. The number of evaluations of the objective functions differs significantly but cannot be directly compared as only the SNOBFIT algorithm does stop when the found solution does not improve further, whereas the other algorithms use a predefined number of function evaluations. Therefore, SNOBFIT has the shortest runtime for both examples. For computationally expensive simulations, it is shown that parallelisation of the function evaluations (SNOBFIT and blackbox) and quantisation of the input variables (SNOBFIT) are essential for the algorithmic performance. For the gas turbine overspeed analysis, only SNOBFIT can compete with the reference procedure concerning the runtime. Further studies will have to investigate whether the quantisation of input variables can be applied to other algorithms and whether the BBO algorithms can outperform the reference methods for problems with a higher dimensionality.
A Systematic Literature Review of the Context of the Sharing Economy and CSR in 2017–2021
Authors: Tetrevova Libena , Kopriva Jan , Zahorska Alexandra 
Published: May 2023

Abstract
The sharing of idle assets, on which the sharing economy model is based, is associated with positive economic, environmental, and social effects, the creation of which is the basis of the concept of corporate social responsibility (CSR). It would therefore seem expedient to examine the context of these phenomena, which have recently been gaining in importance, although they still remain outside mainstream research. So far, there is no study which comprehensively characterises the current state of knowledge of the context of the sharing economy and CSR, identifies research gaps, and postulates directions for future research in this area. This article addresses this gap by utilising a standalone literature review approach. An analysis of 20 publications, published on this topic in 2017–2021 in journals registered in the Web of Science and Scopus databases, was carried out. Four main research clusters were identified, these being (1) The sharing economy as a tool of the CSR concept; (2) The joint contribution of the sharing economy model and the concept of CSR towards reduction of overconsumption and wastage; (3) The importance of CSR communication for sharing economy platforms; and (4) The antagonistic relationship between the sharing economy model and the concept of CSR. The performed analysis shows the fragmented nature of existing research, but also the progressive nature of this area of research. At the same time, useful avenues for future research are postulated. This should focus on multiple lines of inquiry, including the possibility of incorporating different forms of B2B sharing into the concept of CSR, assessing the benefits, limitations, and risks of linking these two concepts, as well as exploring the synergies between the sharing economy model and the concept of CSR from the point of view of different industries, sharing segments, or regions.
Impact Evaluation of the Graduate Practice Intervention in Slovakia with the Application of the CART Method
Authors: Gabrikova Barbora , Svabova Lucia 
Published: May 2023

Abstract
In Slovakia, the contribution to graduate practice is one of the active labour market policy interventions, the main goal of which for young school-leavers is to gain first job experiences and contacts with potential employers. Among the young jobseekers, it is one of the most used interventions. This study aims to provide a counterfactual impact evaluation of this contribution on the employability of its participants and also on their monthly wages. The total period under review is 2014–2017, during which the treated individuals participated in the graduate practice during 2014–2015. Then, their course of employment and average monthly wages were monitored over a two-year impact period, covering the period 2015–2017. The study was carried out using a database of 12,953 treated eligible participants of graduate practice and 83,907 non–treated controls. The data used in the study is managed by the Central Office of Labour, Social Affairs and Family of the Slovak Republic (COLSAF SR) and the Social Insurance Agency (SIA). For the evaluation, propensity score matching was used, where the propensity scores were estimated using classification and regression trees. The results of the study show that the participants of the graduate practice were employed on average three months longer during the two-year impact period after the end of the intervention as full-time employees or self-employed, and their average salary was almost 217 euros higher than that of the control group of non-participants.