bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the antioxidant and anti-inflammatory potential of Nypa fruticans: a multifaceted approach to skin protection and aging
Authors: Kim Seul Ki , Kim Sang-Back , Lee Seul Bi , Kim Kang sub , Son So-Ri , Choi En Jin , Park Byung Chul , Hong Eunyoung , Kim You Ah , Moon Byoung Seok , Lee Sullim 
Published: January 2025

Abstract
Reactive oxygen species (ROS) produced in the mitochondria of skin cells play a significant role in the degradation of the extracellular matrix and induction of inflammatory responses, both of which are major contributors to skin aging. Antioxidants that reduce ROS production and inhibit inflammatory skin lesions are considered beneficial for the treatment of inflammatory skin diseases and prevention of skin aging. In this study, we evaluated the potential of Nypa fruticans (NF), which is known for its antioxidant properties, to mitigate tumor necrosis factor-alpha (TNF-α)- and interferon-gamma (IFN-γ)-induced damage in normal human epidermal keratinocytes. The major active constituents identified in NF include protocatechuic acid, hydroxybenzoic acid, procyanidin B, catechin, and epicatechin. NF significantly suppressed the production of ROS, nitric oxide (NO), and prostaglandin E2 (PGE2), while also reducing the levels of inflammatory cytokines interleukin-6 (IL-6) and interleukin-1 beta (IL-1β), which were elevated by TNF-α/IFN-γ stimulation. Furthermore, NF restored the expression of key skin barrier-related proteins such as serine peptidase inhibitor kazal type 5 (SPINK5), collagen type I alpha 1 chain (COLIA1), loricrin (LOR), aquaporin-3 (AQP3), and filaggrin (FLG). Additionally, NF significantly upregulated the expression of hyaluronan synthase (HAS) -1 and − 2 and human β-defensin (HBD) -2 and − 3, which are important for skin hydration and innate immune defense. These findings underscore the potential therapeutic applications of Nypa fruticans (NF) in mitigating oxidative stress, inflammation, skin barrier dysfunction, dehydration, and microbial imbalances. By targeting multiple pathways implicated in skin aging, NF represents a promising comprehensive approach for preserving skin health and addressing age-related dermatological conditions. Moreover, NF holds significant potential not only to alleviate the manifestations of skin aging but also to provide a basis for the development of innovative dermatological therapies. Future investigations should aim to further elucidate the clinical applications of NF in dermatology to maximize its therapeutic benefits.
How do red foxes (Vulpes vulpes) explore their environment? Characteristics of movement patterns in time and space
Authors: Oehler Felicitas , Hagen Robert , Hackländer Klaus , Walton Zea , Ashish Kumar , Arnold Janosch 
Published: January 2025

Abstract

Background
Many animals must adapt their movements to different conditions encountered during different life phases, such as when exploring extraterritorial areas for dispersal, foraging or breeding. To better understand how animals move in different movement phases, we asked whether movement patterns differ between one way directed movements, such as during the transient phase of dispersal or two way exploratory-like movements such as during extraterritorial excursions or stationary movements.

Methods
We GPS collared red foxes in a rural area in southern Germany between 2020 and 2023. Using a random forest model, we analyzed different movement parameters, habitat features—for example landclasses and distances to linear structures—and time variables (season and time of day) within red fox exploratory, transient and stationary movement phases to characterize phase specific movement patterns and to investigate the influence of different variables on classifying the movement phases.

Results
According to the classification model, the movement patterns in the different phases were characterized most strongly by the variables persistence velocity, season, step length and distance to linear structures. In extraterritorial areas, red foxes either moved straight with high persistence velocity, close to anthropogenic linear structures during transient movements, or more tortuously containing a higher variance in turning angles and a decrease in persistence velocity during exploratory-like movements. Transient movements mainly took place during autumn, whereas exploratory-like movements were mainly conducted during winter and spring.

Conclusion
Movement patterns of red foxes differ between transient, exploratory and stationary phases, reflecting displacement, searching and resident movement strategies. Our results signify the importance of the combined effect of using movement, habitat and time variables together in analyzing movement phases. High movement variability may allow red foxes to navigate in extraterritorial areas efficiently and to adapt to different environmental and behavioral conditions.
Fluid flow in crustal fault zones with varying lengthwise thickness: application to the Margeride fault zone (French Massif Central)
Authors: Penhoët Emmy , Arbaret Laurent , Guillou-Frottier Laurent , Duwiquet Hugo , Gumiaux Charles , Bellanger Mathieu 
Published: January 2025

Abstract
Crustal fault zones, holding promise as potential geothermal reservoirs, remain largely untapped and unexplored. Located in the southern Massif Central, France, the Margeride fault zone (MFZ) varies in thickness (lateral extension perpendicular to the fault plane) from 100 m to over 2500 m. Reactivated several times under different stress regimes since the Variscan orogeny, this zone is characterized by an intense alteration and fracturing. As a result, the multiple reactivation of the fault zone has maintained permeability, leading to favourable conditions for fluid circulation. Structural measurements and geological cross sections were used to precisely constrain thickness and geometry of the fault zone. North of the MFZ, the Coren thermal spring indicates reservoir temperatures of about 200–250 °C, hinting at the possible existence of a temperature anomaly. To investigate this geothermal potential, 3D numerical models simulating fluid circulation within a fault zone were conducted. Various configurations were explored, altering fault zone thickness and permeability for two key geometries. The first geometry, which manipulated the width of the fault zone along its length, demonstrated a direct correlation between fault zone thickness and amplitude of thermal anomaly. Thinner faults (< 500 m) exhibited multiple weak positive thermal anomalies, while thicker faults (> 500 m) tended to develop a single, substantial positive thermal anomaly. In the second examined geometry, where fault zone thickness increased longitudinally, a consistent positive temperature anomaly emerged at the thickest section of the fault zone. Depending on the permeability value, an additional anomaly may develop but will migrate laterally towards the thinnest part of the fault zone. This multi-disciplinary approach, combining numerical modelling and field measurements, presents a predictive methodology applicable to geothermal exploration in analogous basement domains. In our case, it has shown that the northern end of the Margeride fault zone could represent an area that needs to be explored further to assert its high geothermal potential. Our numerical models will increase understanding of how fault width and geometry impact the geothermal potential of the Margeride fault zone and similar areas in crystalline basement.
An overview of evaluating the efficacy of microbial pathogens for biological control of the red palm weevil Rhynchophorus ferrugineus (Olivier, 1790) (Coleoptera: Curculionidae) insights from laboratory and field studies
Authors: Sutanto Koko Dwi , Febrayanto Catur Raharjo , Wiratno Wiratno , Utami Dwinita Wikan , Susiyanti Fitri , Yulianto Mohammad Agus , Meilin Araz , Trisawa Iwa Mara 
Published: January 2025

Abstract

Background
This overview explores the use of entomopathogenic nematodes (EPNs), fungi (EPFs), bacteria (EPBs), and viruses (EPVs) as biological control strategies against the red palm weevil (RPW) (Rhynchophorus ferrugineus), a significant pest of date palms in Saudi Arabia. Laboratory and field studies have evaluated the efficacy of these pathogens, which employ different infection mechanisms to manage RPW populations. The review aims to provide insights into the pathogenicity and application methods of these microbial agents, supporting the development of sustainable integrated pest management strategies for date palm cultivation.

Results
The results indicate that entomopathogenic nematodes (EPNs), fungi (EPFs), bacteria (EPBs), and viruses (EPVs) are effective microbial agents for controlling the red palm weevil (RPW), a significant pest of date palms in Saudi Arabia. Laboratory and field studies have demonstrated their efficacy, utilizing different infection mechanisms to manage RPW populations at various life stages. However, limitations exist, including a lack of comprehensive research on certain microbial pathogens and the need for further studies to optimize application methods and environmental adaptability. These gaps highlight the importance of this review in synthesizing findings and providing a solid foundation for future research on sustainable integrated pest management strategies for RPW control.

Conclusion
This overview underscores the potential of entomopathogenic microorganisms as effective biocontrol agents against the red palm weevil, emphasizing their role in sustainable pest management strategies. Continued research is essential to address existing gaps and optimize the application of these microbial agents in date palm cultivation.
TALome and phenotypic analysis of Pakistani Xanthomonas oryzae pv. oryzae population revealed novel virulent TALEs contributing to bacterial blight of rice
Authors: Shah Syed Mashab Ali , Ahsan Rafia , Liu Linlin , Li Ying , Wang Qi , Wang Yong , Yan Jiali , Khojasteh Moein , Xu Xiameng , Xu Zhengyin , Rasheed Awais , Zakria Muhammad , Chen Gongyou 
Published: January 2025

Abstract
Bacterial blight (BB) of rice caused by Xanthomonas oryzae pv. oryzae (Xoo), is an important disease in rice-growing countries, including Pakistan, where it was first reported in the mid-1970s. Transcription activator-like effectors (TALEs) play vital roles in many plant diseases caused by Xanthomonas spp.; however, Pakistani Xoo TALome diversity and their contribution to pathogenicity is largely unknown. In this study, 101 Xoo strains were screened using specific PCR primers. The genomic DNA from these strains underwent BamHI digestion and hybridized with the internal SphI fragment of PthXo1. Southern blot analysis revealed 16 to 20 putative tale fragments among the tested strains. These strains were further classified into 11 genotypes based on the number and size of the hybridizing bands. Genotypes 1, 2, 3, and 4 represented 24, 2, 51, and 17 strains, respectively. Pathogenicity assays on near-isogenic lines (NILs) containing different resistance (R) genes exhibited that CBB23 was incompatible with all tested Pakistani-Xoo genotypes, whereas IRBB5 and IRBB4 showed resistance against specific genotypes. In contrast, paddy trails on NILs containing single, double, and triple mutants of OsSWEET11a, OsSWEET13, and OsSWEET14 in the effector binding elements (EBEs) of cv. Kitaake revealed that KP-22 and LD-5 harbor novel virulent TAL effector/s. Interestingly, the expression analysis of six clade-III OsSWEET genes suggests that novel TALE/s targeting unidentified susceptibility gene/s. Altogether, this study highlights gene-for-gene relationships between tested rice lines and Pakistani-Xoo strains. This is the first report providing the diversity of TALEs and their relationship to R and S (susceptibility) genes. Further identification of novel virulent TALE/s and their cognate target/s is warranted to precisely elucidate their role in BB.
Use of implementation logic models in the Quadruple Aim QUERI: conceptualization and evolution
Authors: Glasgow Russell E. , McCreight Marina S. , Morgan Brianne , Sjoberg Heidi , Hale Anne , Motta Lexus Ujano-De , McKown Lauren , Kenney Rachael , Gilmartin Heather , Jones Christine D. , Frank Joseph , Rabin Borsika A. , Battaglia Catherine 
Published: January 2025

Abstract

Background
Implementation strategies are essential to deliver evidence-based programs that align with local context, resources, priorities, and preferences. However, it is not always clear how specific strategies are selected (vs. others) and strategies are not always operationalized clearly, distinctly, and dynamically. Implementation logic models provide one useful way to conceptualize the role and selection of implementation strategies, plan evaluation of their intended impacts on implementation and effectiveness outcomes, and to communicate key aspects of a project.

Methods
This paper describes our initial plans, experiences, and lessons learned from applying implementation logic models in the Quadruple Aim Quality Enhancement Research Initiative (QUERI) a large multi-study program funded by the Veterans Health Administration (VA). We began with two primary implementation strategies based on our earlier work (i.e., Iterative RE-AIM and Relational Facilitation) that were applied across three different health outcomes studies.

Results
Our implementation strategies evolved over time, and new strategies were added. This evolution and reasons for changes are summarized and illustrated with the resulting logic models, both for the overall Quadruple Aim QUERI and the three specific projects. We found that implementation strategies are often not discrete, and their delivery and adaptation is dynamic and should be guided by emerging data and evolving context. Review of logic models across projects was an efficient and useful approach for understanding similarities and differences across projects.

Conclusions
Implementation logic models are helpful for clarifying key objectives and issues for both study teams and implementation partners. There are challenges in logic model construction and presentation when multiple strategies are employed, and when strategies change over time. We recommend presentation of both original and periodically updated project models and provide recommendations for future use of implementation logic models.
High triglyceride-glucose index in patients with diabetes mellitus is associated with an increased likelihood of nephropathy development: evidence from a meta-analysis among Asian population
Authors: Tiongco Raphael Enrique , Cayanan Neil David , Dominguez Michael John , Geonzon Kyll , Mercado Julie Ann , Pineda-Cortel Maria Ruth 
Published: January 2025

Abstract

Introduction
In recent years, the triglyceride-glucose (TyG) index, which is associated with insulin resistance and kidney dysfunction, has emerged as a promising and accessible biomarker for the diagnosis and prognosis of diabetic nephropathy (DN). In this study, we examined the association of TyG in DN by meta-analyzing relevant literature.

Methods
Literature search and serial omissions of articles yielded eight studies for inclusion in the meta-analysis. Relevant data were extracted from the included studies and were subjected to analysis using Review Manager 5.4. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were computed from the included studies. Subgroup analysis was also performed to control for the participant's ethnicity.

Results
Out of the 1,229 resulting studies, only eight were included based on the set inclusion criteria. The overall pooled outcomes resulted in significant and homogeneous findings favoring the development of DN among patients with diabetes due to high levels of TyG. The findings of the present study are supported by the homogeneous outcomes, stability of findings, and high significance level.

Conclusion
Overall, our results show that high levels of TyG are associated with DN development, especially among the Asian population with diabetes. However, further longitudinal and multi-ethnic studies are needed to verify these claims.
Assessment of Rare Cancers and Sarcoma Policy and Sarcoma Drug Approvals in Latin America: A Report From the LACOG Sarcoma Group
Authors: Dias e Silva Douglas , Lopes David Bruna Bianca , Pires de Camargo Veridiana , Zon Filipi Renee , González Donna María Lucila , Haro Varas Juan Carlos , Ramella Munhoz Rodrigo , Zapata Maycos L. , Cunha Martins Cicero Luiz , Chacon Matias , Schmerling Rafael , Jesus Garcia Reynaldo , Carmagnani Pestana Roberto 
Published: January 2025

PURPOSE
The availability of drugs and national public policies for patients with rare cancers, including sarcomas, varies in different parts of the world.

METHODS
In this manuscript, we have conducted a comprehensive analysis to evaluate rare cancer policies in Latin American countries' national policy documents. Additionally, we have reviewed the approvals for sarcoma drugs in selected Latin American countries and compared them with US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approvals.

RESULTS
The documents reviewed showed a lack of explicit focus on rare cancers, with no mention in 70% of the countries analyzed. Drug approval data reveal that in the last 15 years, the FDA and EMA have approved 19 and 13 drugs for sarcoma, whereas their Latin American counterparts, namely ANVISA, ANMAT, and COFEPRIS, approved six, eight, and seven drugs, respectively.

CONCLUSION
Our data suggest that improving rare cancer and sarcoma care in Latin America requires enhanced collaboration for better rare cancer policies.
Sensorimotor Physiological Mapping During Asleep Deep Brain Stimulation Lead Placement With Multichannel Intraoperative Neuromonitoring
Authors: Yamaguchi Craig , Anwar Hamsat , Lesko Alyx , Kaber Stacy M. , Oliveria Seth F. 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Lead placement during asleep deep brain stimulation (DBS) surgery has relied primarily on intraoperative imaging, forgoing traditional awake neurophysiological testing. We aimed to describe our experience of asleep macrostimulation mapping of implanted DBS leads using intraoperative neuromonitoring (IONM) techniques, which were used to guide electrode placement—in addition to intraoperative computed tomography imaging and in place of awake neurophysiological testing.

METHODS:
This was a single institution retrospective study of asleep DBS surgery with IONM mapping for Parkinson's disease, ET, and dystonia targeting the ventral intermediate nucleus, subthalamic nucleus, and globus pallidus interna.

RESULTS:
A series of 88 consecutive patients from a single surgeon were included. 67 patients received DBS for Parkinson's disease, 14 for essential tremor, and 7 for dystonia. The DBS target was globus pallidus interna for 60 patients, subthalamic nucleus for 14, and ventral intermediate nucleus for 14, with 95.5% undergoing bilateral lead placement. The mean single stage surgery time was 170 minutes. No patients required surgical lead revision, and no unanticipated sensorimotor side effects were noted during DBS programming. Compared with patients undergoing awake DBS surgery, there was no significant difference in patient-reported outcomes.

CONCLUSION:
Asleep IONM mapping offers valuable physiological data to guide electrode asleep DBS placement and complement intraoperative imaging techniques.
ECOLOGICAL FUNCTION OF THE STATE AND PROBLEMS OF ITS REALIZATION IN MODERN CONDITIONS
Authors: Ryzhov Alexey A. 
Published: January 2025

The article deals with the environmental function of the state and the problems of its realisation in modern conditions. The study covers key aspects of the state environmental policy, including legal regulation, interaction with the private sector and civil society. Particular attention is paid to analysing the factors that hinder the effective implementation of the environmental function, such as lack of funding, imperfect law enforcement practices and contradictions between economic and environmental interests, which in turn negatively affects environmental security as a whole. The paper also offers recommendations for improving the implementation of the state’s environmental function, taking into account modern global challenges and trends in the transition to sustainable development. In the process of the research various opinions and approaches of many authors who have studied the topic of ecological function of the state have been analysed. The article also reflects different approaches to the definition of the essence of such legal category as ‘ecological function of the state’. It is proposed to use not only legal mechanisms for the implementation of environmental function, but also to use tax, sociological, economic tools that will make compliance with environmental legislation and minimisation of harmful impact on the environment a fashionable and economically beneficial activity. The variants and measures of realisation of ecological function are offered, introduction of which in practical activity will allow to improve quality of realisation of ecological function by the state that will positively reflect on ecological safety.
Results. The result of the work is a comprehensive study of such a legal category as ‘environmental function of the state’. The author, having studied the opinions of scientists on this problem, proposed to use a universal concept in doctrine. It is proposed to introduce in practice measures of economic nature, namely: tax breaks, subsidies, creation of a state fund for ecological restoration. The introduction of these measures will allow to contribute to a greater extent to ensuring environmental security.
Scope of application of the results. The results of the study can be applied in the doctrine of environmental law, as well as in legislative activity, when improving the legal framework regulating environmental legal relations.
Kidney Function and Extreme Endurance Races: Risks, Mechanisms, and Preventing Strategies
Authors: Kulbacka Julia , Dziedzic Karol , Arczewski Filip , Wójcikiewicz Michalina , Chuncia-Ileczko Marta , Kacperczyk Julia , Czyż Witold , Zys Damian , Pasek Piotr , Ryniecka Julia 
Published: January 2025

Background: The increasing popularity of ultra-endurance sports emphasizes the need for a deeper understanding of their health implications, particularly the impact on kidney function. Given the kidneys’ crucial role in waste filtration, fluid and electrolyte balance, and their close connection to the physiological demands of intense physical activity, it requires detailed investigation from this perspective.
Purpose: The objective of this study is to present the current state of knowledge on the topic of kidney function in the context of ultra-endurance sports. It examines the risk factors, underlying mechanisms, and potential strategies for preventing renal injuries associated with these specific types of physical activities.
Findings: Ultra-endurance sports present significant risks to kidney health, including acute kidney injury (AKI) estimated to affect approximately 40% of participants, rhabdomyolysis and dehydration, which are often compounded by additional factors such as gastrointestinal distress and the use of non-steroidal anti-inflammatory drugs (NSAIDs). There is a need for improved diagnostic criteria to detect acute renal injury in this population, with novel biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and cystatin C showing promise. A multifaceted preventive approach including strategies such as mandatory pre-event screening, the use of personal monitoring devices, proper hydration and nutrition, adequate race preparation, and the avoidance of NSAIDs is crucial to mitigate these risks and maintain renal health in ultra-endurance athletes.