bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications
Authors: McElligott Brian , Shi Zhuqing , Rifkin Andrew S. , Wei Jun , Zheng S. Lilly , Helfand Brian T. , Woo Jonathan S. H. , Xu Jianfeng 
Published: February 2023

BackgroundPatients with sepsis are at increased risk for cardiovascular complications, including myocardial infarction (MI), ischemic stroke (IS), and venous thromboembolism (VTE). Our objective is to assess whether genetic risk score (GRS) can differentiate risk for these complications.MethodsA population-based prospective cohort of 483,177 subjects, derived from the UK Biobank, was followed for diagnosis of sepsis and its complications (MI, IS, and VTE) after the study recruitment. GRS for each complication was calculated based on established risk-associated single nucleotide polymorphisms (SNPs). Time to incident MI, IS, and VTE was compared between subjects with or without sepsis and GRS risk groups using Kaplan–Meier log-rank test and Cox-regression analysis.ResultsDuring an average of 12.6 years of follow-up, 10,757 (2.23%) developed sepsis. Patients with sepsis had an overall higher risk than non-sepsis subjects for each complication, but the risk differed by time after a sepsis diagnosis; exceedingly high in short-term (0–30 days), considerably high in mid-term (31 days to 2 years), and reduced in long-term (&gt;2 years). Furthermore, in White subjects, GRS was a significant predictor of complications, independent of sepsis and other risk factors. For example, GRSMI further differentiated their risk in patients with sepsis; 3.49, 4.73, and 9.03% in those with low- (&lt;0.5), intermediate- (0.5–1.99), high- GRSMI (≥2.0), Ptrend &lt; 0.001.ConclusionRisk for post-sepsis cardiovascular complications differed considerably by time after a sepsis diagnosis and GRS. These findings, if confirmed in other ancestry-specific populations, may guide personalized management for preventing post-sepsis cardiovascular complications.
Response of wood decomposition to different forms of N deposition in subtropical forests
Authors: Wu Chunsheng , Shu Chunjie , Yuan Xi , Deng Bangliang , Shen Fangfang , Zhang Yi , Liu Yuanqiu 
Published: February 2023

AimsWood decomposition plays an important role in ecosystem soil fertility and nutrient cycling, but how different forms of nitrogen (N) affect these biogeochemical processes is still unclear. The effects of N deposition on wood decomposition have been widely studied, but the decomposition process and biotic driver response to different forms of N have rarely been studied.MethodsIn this study, we conducted a two-year field factorial fertilization experiment with different N forms in a subtropical Chinese forest. Glycine and urea were selected as organic N (ON), and ammonium nitrate was selected as inorganic N (IN). Six different ratios (control, 0:10, 3:7, 5:5, 7:3, 10:0) of IN:ON with equal N amounts were uniformly added to the studied wood.ResultsWe found that both forms of N deposition, i.e., ON and IN, accelerated the wood decomposition rates across the four studied species, and the magnitude of the increase was species specific. Mixed fertilizer with ON and IN resulted in the highest responses in the wood decomposition rate, which was 1.73- and 1.48-fold higher than that in the control and in response to IN addition alone across species. The ON + IN treatment resulted in the highest faunal and microbial community abundance of the decomposing wood.ConclusionIn summary, our results indicate that different forms of anthropogenic N enrichment can promote wood decomposition through the modification of microbial and faunal communities in the wood decomposition process. Our results show that future studies need to consider N forms and components when estimating exogenous N deposition effects on the woody material nutrient cycle and terrestrial ecosystem carbon cycles.
Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry
Authors: Busca Alessandro , Salmanton-García Jon , Marchesi Francesco , Farina Francesca , Seval Guldane Cengiz , Van Doesum Jaap , De Jonge Nick , Bahr Nathan C. , Maertens Johan , Meletiadis Joseph , Fracchiolla Nicola S. , Weinbergerová Barbora , Verga Luisa , Ráčil Zdeněk , Jiménez Moraima , Glenthøj Andreas , Blennow Ola , Tanase Alina Daniela , Schönlein Martin , Prezioso Lucia , Khanna Nina , Duarte Rafael F. , Žák Pavel , Nucci Marcio , Machado Marina , Kulasekararaj Austin , Espigado Ildefonso , De Kort Elizabeth , Ribera-Santa Susana José-María , Marchetti Monia , Magliano Gabriele , Falces-Romero Iker , Ilhan Osman , Ammatuna Emanuele , Zompi Sofia , Tsirigotis Panagiotis , Antoniadou Anastasia , Zambrotta Giovanni Paolo Maria , Nordlander Anna , Karlsson Linda Katharina , Hanakova Michaela , Dragonetti Giulia , Cabirta Alba , Berg Venemyr Caroline , Gräfe Stefanie , Van Praet Jens , Tragiannidis Athanasios , Petzer Verena , López-García Alberto , Itri Federico , Groh Ana , Gavriilaki Eleni , Dargenio Michelina , Rahimli Laman , Cornely Oliver A. , Pagano Livio ,   EPICOVIDEHA Consortium
Published: February 2023

BackgroundThe outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT.MethodsThis multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022.ResultsThe median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53).ConclusionsMortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.
Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-κB/NLRP3/GSDMD and GSDME signaling pathway
Authors: Ding Mengyang , Liu Jingyu , Lv Honghui , Zhu Yanlin , Chen Yumiao , Peng Hui , Fan Sairong , Chen Xiaoming 
Published: February 2023

BackgroundPancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is a highly lethal malignancy with poor prognosis. Polypeptide N-acetylgalactosaminyltransferase-6 (GALNT6) is frequently overexpressed in PDAC. However, the role of GALNT6 in the PDAC remains unclear.MethodsThe expression of GALNT6 in pancreatic cancer and normal tissues were analyzed by bioinformatic analyses and immunohistochemistry. CCK8 and colony formation were used to detect cell proliferation. Flow cytometry was applied to detect cell cycle.The pyroptosis was detected by scanning electron microscopy. The mRNA expression was detected by qRT-PCR. The protein expression and localization were detected by western blot and immunofluorescence assay. ELISA was used to detect the levels of inflammatory factors.ResultsThe expression of GALNT6 was associated with advanced tumor stage, and had an area under curve (AUC) value of 0.919 in pancreatic cancer based on the cancer genome atlas (TCGA) dataset. Knockdown of GALNT6 inhibited cell proliferation, migration, invasion and cell cycle arrest of PDAC cells. Meanwhile, knockdown of GALNT6 increased the expression levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18), the release of inflammasome and an increasing of Gasdermin D (GSDMD), N-terminal of GSDMD (GSDMD-N), Gasdermin E (GSDME) and N-terminal of GSDME (GSDME-N) in PDAC cells. GALNT6 suppressed the expression of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and GSDMD by glycosylation of NF-κB and inhibiting the nucleus localization of NF-κB. Additionally, GALNT6 promotes the degradation of GSDME by O-glycosylation.ConclusionWe found that GALNT6 is highly expressed in pancreatic cancer and plays a carcinogenic role. The results suggested that GALNT6 regulates the pyroptosis of PDAC cells through NF-κB/NLRP3/GSDMD and GSDME signaling. Our study might provides novel insights into the roles of GALNT6 in PDAC progression.
Relationships reduce risks for child maltreatment: Results of an experimental trial of Infant Mental Health Home Visiting
Authors: Julian Megan M. , Riggs Jessica , Wong Kristyn , Lawler Jamie M. , Brophy-Herb Holly E. , Ribaudo Julie , Stacks Ann , Jester Jennifer M. , Pitzen Jerrica , Rosenblum Katherine L. , Muzik Maria ,   on behalf of The Michigan Collaborative for Infant Mental Health Research (MCIMHR)
Published: February 2023

BackgroundResearch examining the effectiveness of home visiting programs that reduce child maltreatment or associated risks yield mixed findings; some find positive significant impacts on maltreatment, whereas others find small to no effects. The Michigan Model of Infant Mental Health Home Visiting (IMH-HV) is a manualized, needs-driven, relationship-focused, home-based intervention service that significantly impacts maternal and child outcomes; the effect of this intervention on child maltreatment has not been sufficiently evaluated.ObjectiveThe current study examined associations between treatment and dosage of IMH-HV and child abuse potential in a longitudinal, randomized controlled trial (RCT).Participants and settingParticipants included 66 mother-infant dyads (Mother M age = 31.93 years at baseline; child M age = 11.22 months at baseline) who received up to 1 year of IMH-HV treatment (Mdn = 32 visits) or no IMH-HV treatment during the study period.MethodsMothers completed a battery of assessments including the Brief Child Abuse Potential Inventory (BCAP) at baseline and at the 12-month follow-up assessment.ResultsRegression analyses indicated that after controlling for baseline BCAP scores, those who received any IMH-HV treatment had lower 12-month BCAP scores compared to those who received no treatment. Additionally, participation in more visits was associated with lower child abuse potential at 12 months, and a reduced likelihood of scoring in the risk range.ConclusionFindings suggest that greater participation in IMH-HV is associated with decreased risk for child maltreatment 1 year after initiating treatment. IMH-HV promotes parent-clinician therapeutic alliance and provides infant-parent psychotherapy which differentiate it from traditional home visiting programs.
Thermal strain is greater in the late afternoon than morning during exercise in the gym without airflow and air conditioning on a clear summer day
Authors: Otani Hidenori , Goto Takayuki , Kobayashi Yuki , Goto Heita , Shirato Minayuki , Hosokawa Yuri , Tokizawa Ken , Kaya Mitsuharu 
Published: February 2023

IntroductionThere are no reports examining the time-of-day effect on team training sessions in the gym without airflow and air conditioning on thermal strain in the summer heat. We investigated this effect during badminton training sessions on a clear summer day.MethodsNine male high school badminton players (Mean ± SD; age 17.1 ± 0.6 y, height 171 ± 4 cm, body mass 59 ± 7 kg) completed two 2.5-h badminton training sessions in the gym without airflow and air conditioning. The training sessions were started at 0900 h (AM) and 1600 h (PM) on separate days in August. Skin temperatures (chest, triceps, thigh, calf), infrared tympanic temperature, heart rate, thermal sensation and rating of perceived exertion were recorded at rest and at regular intervals during the sessions.ResultsIndoor and outdoor environmental heat stress progressively increased in AM and decreased in PM during the sessions. Ambient temperature (AM 30.1 ± 0.9°C; PM 33.2 ± 1.0°C: P &lt; 0.001) and wet-bulb globe temperature (AM 28.1 ± 0.5°C; PM 30.0 ± 0.9°C: P = 0.001) during the sessions in the gym were higher in PM than AM. Mean skin temperature (AM 34.2 ± 1.0°C; PM 34.7 ± 0.7°C: P &lt; 0.001), infrared tympanic temperature (AM 37.8 ± 0.5°C; PM 38.1 ± 0.4°C: P = 0.001) and thermal sensation (AM 2.7 ± 1.4; PM 3.3 ± 1.0: P &lt; 0.001) during the sessions were higher in PM than AM. Body heat storage (AM 159 ± 30 W·m−2; PM 193 ± 30 W·m−2: P &lt; 0.05) was greater in PM than AM. There were no time-of-day differences in the average heart rate (AM 75 ± 4% age-predicted maximal heart rate; PM 76 ± 5 age-predicted maximal heart rate: P = 0.534), body mass loss (AM 0.6 ± 0.3 kg; PM 0.8 ± 0.2°C: P = 0.079), the volume of water ingested (AM 1.5 ± 0.1 L; PM 1.6 ± 0.3 L: P = 0.447) and rating of perceived exertion (AM 16 ± 2; PM 16 ± 3: P = 0.281).ConclusionsThis study indicates greater thermal strain in PM trial than in AM trial during team training sessions in the gym without airflow and air conditioning on a clear summer day. Therefore, athletes and coaches of indoor sports should perceive that athletes may be exposed to a greater risk for thermal strain in the late afternoon from 1600 h than in the morning from 0900 h during the sessions in the gym under these conditions.
Maximizing Energy Performance of University Campus Buildings through BIM Software and Multicriteria Optimization Methods
Authors: Tsantili Angeliki , Koronaki Irene , Polydoros Vasilis 
Published: February 2023

University buildings have high energy requirements due to their size, numerous users, and activities, which considerably contribute to environmental contamination. Implementing energy-saving solutions in these structures has a favorable influence on the economics and the conservation of energy resources. A higher education building’s energy behavior can be simulated using software to identify the optimal strategies that result in energy savings. In this research, Autodesk Revit, Autodesk Insight, and Green Building Studio are among the programs utilized to examine the energy efficiency of the university building in four European cities. Following the development of several energy-saving scenarios for the building, the offered solutions are evaluated based on their annual energy consumption, energy costs, and CO2 emissions. Finally, multicriteria analysis techniques such as the AHP and PROMETHEE are applied to choose the best scenario for each instance. The study’s findings indicate that the ASHRAE Terminal Package Heat Pump scenario performed well in all of the cities examined, reducing yearly energy usage by 43.75% in Wien and annual energy costs by 47.31% in Mallorca. In comparison, the scenario utilizing a high-efficiency VAV system with a gas boiler and chiller came in last in all situations, resulting in a decrease of 12.67% in Mallorca’s annual energy usage and a reduction of 17.57% in Palermo’s annual energy expenses.
Penggunaan Tepung Karagenan Sebagai Pengganti Pektin Dalam Pembuatan Selai Buah
Authors: Luthfi Tristy Firlyanie 
Published: February 2023

Penelitian ini merupakan kontribusi terhadap pemanfaatan rumput laut yang diolah menjadi tepung karagenan sebagai pengganti pektin untuk pembuatan selai buah. Tujuan dari penelitian ini adalah untuk membuktikan bahwa tepung karagenan yang berasal dari tumbuhan rumput laut memiliki fungsi yang sama dengan pektin dan dapat menjadi bahan pengganti dalam pembuatan selai buah. Pada penelitian ini, penulis akan menggunakan metode eksperimental yakni metode percobaan dan observasi sistematis terhadap objek eksperimen, hanya beberapa faktor saja yang diamati dan dikenakan perlakuan-perlakuan tertentu dengan kondisi-kondisi yang dapat dikontrol sehingga penulis bisa mengamati proses eksperimennya. Jenis selai buah yang digunakan adalah selai nanas karena nanas merupakan buah yang paling umum digunakan dalam pembuatan selai buah. Hasil dari penelitian ini adalah tepung karagenan memiliki fungsi yang sama dengan pektin untuk proses pengentalan pada selai buah dan untuk uji organoleptic (rasa, tekstur, aroma dan warna), selai buah yang menggunakan 50% tepung karagenan memiliki selisih rata-rata yang kecil dibandingkan dengan selai yang menggunakan 100% pektin.
Wisata Makam, Sebuah Pergeseran Nilai-Nilai Religiusities, Dari Wisata Agama Menjadi Wisata Budaya (Animism)
Authors: Supriadi Herman , Irwan Rahadi  , H. M. Mugni  
Published: February 2023

Kuatnya pengaruh budaya, menyebabkan terjadinya akulturasi budaya dengan agama. Sebagai akibat dari akulturasi ini maka terjadi pergeseran nilai agama yang seharusnya mengikuti aturan yang telah diajarkan oleh tuhan menjadi praktik-praktik kebudayaan yang dibuat oleh manusia. Hasil dari pergeseran ini membuat nilai dasar (motivasi) agama terutama dalam hal ini agama Islam menjadi berubah. Inilah yang menjadi tujuan dari penenlitian ini yaitu untuk mengetahui pergeseran nilai-nilai agama dalam praktik ritual wisata makam. Fokus pada penelitian ini adalah makam pahlawan nasional sekaligus seorang ulama kharismatik di pulau Lombok yaitu Maulana Syeikh Muhammad Zainuddin Abdul majdid. Dari kuesioner yang disebar, peneliti mendapatkan 157 respondents. Dari data yang sudah ditabulasikan didapatkan motivasi peziarah makam Maulana syeikh Muhammad Zainuddin Abdul Madjid terklasifikasi menjadi delapan kelompok. Delapan kelompok ini salah satunya adalah ritual tertentu (berobat) dimana sekitar 9 pengunjung atau 9.6% pengunjung dari keseluruhannya telah menyimpang dari ajaran agama Islam yang mengajarkan untuk meminta sepenuhnya kepada tuhan. Dengan demikian bisa kita mendapatkan simpulkan bahwa pemahaman masyarakat mengenai Islam belum kaffah (menyeluruh) sesuai dengan anjuran agama. Sehingga Perlu kiranya bagi para ulama atau sekolah sekolah yang kurikulumya agama untuk lebih meningkatkan peran mereka untuk berdakwah lebih massive lagi sehingga agama Islam bisa dipraktikkan sesuai dengan ajaran tuhan.
Preferensi Pemilihan Daerah Tujuan Wisata oleh Wisatawan Masa Pandemi Covid-19 di Jawa Barat
Authors: Gunawan Hendra , Rachim Sugiarti 
Published: February 2023

The Coronavirus desease-19 pandemic since the beginning of 2020 has had a negative impact on the tourism sector, not only reducing the number of visits but also changing the trend of choice of tourist destinations. This study aims to assess people's preferences towards tourist destinations during the pandemic. A survey using a questionnaire was conducted on 90 visitors to the National Flower and Animal Love Day exhibition at the Bogor Botanical Garden. The results of the study found that natural tourism became a trend during the pandemic, reaching 48.9% with the main objective of enjoying a pristine environment, a quiet and calm atmosphere, and cool and fresh air. Botanical gardens have the highest selection index for residents over the age of 50, while zoos, safari parks, national parks and natural parks have the highest selection index for the age group of adolescents to 20 years. Zoos and safari parks were favored by informants from the city, botanical gardens were favored by informants from the village, while national parks and natural parks were favored by both. Extreme tourism activities are preferred by the 31–40-year age group, moderate activities are preferred by the 41–50-year age group, while special interest tourism is preferred by the age group of 50 years and over. There is a trend of male informants liking natural tourism and modern tourism, while female informants like cultural, culinary and religious tourism. Due to changes in preferences for selecting tourist destinations and types of tourist activities, tourism managers are advised to carry out various product innovations or tour packages, visitor services, promotion/marketing, improve visitor facilities adapted to new normal conditions, and continue to implement health protocols.
ESTRATÉGIAS DE EXPLORAÇÃO DA SITUAÇÃO CONTRAINTUITIVA “JOGO INTERROMPIDO” POR ALUNOS DO ENSINO MÉDIO
Authors: Fernandes José António 
Published: February 2023

Neste artigo analisam-se as estratégias de resolução de uma situação contraintuitiva por alunos do ensino médio e extraem-se algumas implicações do uso desta tarefa para o ensino de Probabilidades. A situação contraintuitiva é uma versão mais simples do famoso problema colocado por Chevalier de Méré a Pascal, que trata da questão da divisão do prémio num jogo que foi interrompido antes de ter terminado. Participaram no estudo 203 alunos do ensino médio que responderam a um questionário com nove questões de Probabilidades, entre a quais se incluía a situação contraintuitiva objeto deste estudo. Em termos de resultados, salienta-se que os alunos adotaram estratégias variadas, em que combinam argumentos analíticos com argumentos intuitivos e em que está muito presente a ideia de equidade, seja ao nível das partidas do jogo ou do jogo. Por outro lado, essa diversidade de estratégias e a mobilização de aspetos analíticos e intuitivos revelam o potencial da tarefa para a sua exploração em termos do ensino de Probabilidades. Tal diversidade, ao favorecer o confronto, a discussão e a partilha entre os alunos, promove a construção de um conceito de probabilidade multifacetado e, em última instância, bem integrado na mente do aprendiz.
Palavras-chave: Probabilidades; Situação contraintuitiva; Estratégias de resolução; Alunos do ensino médio.
PAR OU ÍMPAR: M (2) ou ~M (2)? 2N OU 2N + 1?
Authors: Porto Rozimeire , Sandramagina@gmail.com Sandra Maria Pinto Magina 
Published: February 2023

Este artigo é um recorte de uma pesquisa de mestrado em Educação Matemática que investigou as competências e os esquemas que os estudantes dos 3º e 5º anos do Ensino Fundamental apresentam em situações-problemas e os níveis de raciocínio algébricos mobilizados nessas situações. Teve por suporte uma metodologia descritiva com abordagem diagnóstica. O objetivo proposto foi identificar e compreender a natureza das estratégias apresentadas nos teoremas-em-ação e relacioná-las ao campo aritmético e algébrico simultaneamente. Para tanto foram selecionadas três situações-problema da pesquisa original juntamente com os extratos dos protocolos de respostas de oito estudantes. Na análise qualitativa identificamos nas estratégias resolutivas dos estudantes uma coexistência entre a aritmética e álgebra, uma relação de continuidade filial. Verificamos que, nas relações operacionais adotadas na resolução das situações-problemas (ou tentativas), o estudante ao generalizar e/ou explicitar uma sequência numérica, mesmo sem saber, transitaram entre os campos da aritmética e a álgebra. O estudo demonstrou que situações-problema de natureza aritmética se mediada por um viés algébrico poderá ser explorado nas atividades de ensino da Matemática desde os primeiros anos escolares como proposta formativa do raciocínio algébrico precoce.
Palavras-chaves: aritmética- álgebra-anos iniciais-Ensino Fundamental