bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart Biomaterials for Articular Cartilage Repair and Regeneration
Authors: Gu Zhanghao , Wang Jiayi , Fu Yu , Pan Hao , He Hongyan , Gan Qi , Liu Changsheng 
Published: January 2023

AbstractArticular cartilage defects bring about disability and worldwide socioeconomic loss, therefore, articular cartilage repair and regeneration is recognized as a global issue. However, due to its avascular and nearly acellular characteristic, cartilage tissue regeneration ability is limited to some extent. Despite the availability of various treatment methods, including palliative drugs and surgical regenerative therapy, articular cartilage repair and regeneration still face major challenges due to the lack of appropriate methods and materials. Smart biomaterials can regulate cell behavior and provide excellent tissue repair and regeneration microenvironment, thus inducing articular cartilage repair and regeneration. This process is adjusted by controlling drug/bioactive factors release via responding to exogenous/endogenous stimuli, tailoring materials’ structure and function similar to native cartilage or providing physiochemical and physical signaling factors. Herein, smart biomaterials, recently applied in articular cartilage repair and regeneration, are elaborated from two aspects: smart drug release system and smart scaffolds. Furthermore, articular cartilage and its defects and advanced manufacturing techniques of smart biomaterials are discussed in brief. Finally, perspectives for smart biomaterials used in articular cartilage repair and regeneration are presented and the clinical translation of smart biomaterials is emphasized.
Preparation of 2D Polyaniline/MoO3−x Superlattice Nanosheets via Intercalation‐Induced Morphological Transformation for Efficient Chemodynamic Therapy
Authors: Hu Tingting , Xue Baoli , Meng Fanqi , Ma Lu , Du Yonghua , Yu Shilong , Ye Ruquan , Li Hai , Zhang Qinghua , Gu Lin , Zhou Zhan , Liang Ruizheng , Tan Chaoliang 
Published: January 2023

AbstractOrganic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge. Herein, the preparation of 2D polyaniline/MoO3−x (PANI/MoO3−x) superlattice nanosheets via intercalation‐induced morphological transformation from MoO3 nanobelts, as efficient Fenton‐like reagents for chemodynamic therapy (CDT), is reported. Micrometer‐long MoO3 nanobelts are co‐intercalated with Na+/H2O followed by the guest exchange with aniline monomer for in situ polymerization to obtain PANI/MoO3−x nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO3 nanobelts to 2D PANI/MoO3−x nanosheets along with the partial reduction of Mo6+ to Mo5+, and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation‐induced activation, the PANI/MoO3−x nanosheets exhibit excellent Fenton‐like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H2O2 compared with the MoO3 nanobelts. It is speculated that the good conductivity of PANI can facilitate electron transport during the Fenton‐like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone‐modified PANI/MoO3−x nanosheets can function as Fenton‐like reagents for highly efficient CDT to kill cancer cells and eradicate tumors.
Printing on Particles: Combining Two‐Photon Nanolithography and Capillary Assembly to Fabricate Multimaterial Microstructures
Authors: van Kesteren Steven , Shen Xueting , Aldeghi Michele , Isa Lucio 
Published: January 2023

AbstractAdditive manufacturing at the micro‐ and nanoscale has seen a recent upsurge to suit an increasing demand for more elaborate structures. However, the integration of multiple distinct materials at small scales remains challenging. To this end, capillarity‐assisted particle assembly (CAPA) and two‐photon polymerization direct laser writing (2PP‐DLW) are combined to realize a new class of multimaterial microstructures. 2PP‐DLW and CAPA both are used to fabricate 3D templates to guide the CAPA of soft‐ and hard colloids, and to link well‐defined arrangements of functional microparticle arrays produced by CAPA, a process that is termed “printing on particles.” The printing process uses automated particle recognition algorithms to connect colloids into 1D, 2D, and 3D tailored structures, via rigid, soft, or responsive polymer links. Once printed and developed, the structures can be easily re‐dispersed in water. Particle clusters and lattices of varying symmetry and composition are reported, together with thermoresponsive microactuators, and magnetically driven “micromachines”, which can efficiently move, capture, and release DNA‐coated particles in solution. The flexibility of this method allows the combination of a wide range of functional materials into complex structures, which will boost the realization of new systems and devices for numerous fields, including microrobotics, micromanipulation, and metamaterials.
Heterogeneous Structure Omnidirectional Strain Sensor Arrays With Cognitively Learned Neural Networks
Authors: Lee Jun Ho , Kim Seong Hyun , Heo Jae Sang , Kwak Jee Young , Park Chan Woo , Kim Insoo , Lee Minhyeok , Park Ho‐Hyun , Kim Yong‐Hoon , Lee Su Jae , Park Sung Kyu 
Published: January 2023

AbstractMechanically stretchable strain sensors gain tremendous attention for bioinspired skin sensation systems and artificially intelligent tactile sensors. However, high‐accuracy detection of both strain intensity and direction with simple device/array structures is still insufficient. To overcome this limitation, an omnidirectional strain perception platform utilizing a stretchable strain sensor array with triangular‐sensor‐assembly (three sensors tilted by 45°) coupled with machine learning (ML) ‐based neural network classification algorithm, is proposed. The strain sensor, which is constructed with strain‐insensitive electrode regions and strain‐sensitive channel region, can minimize the undesirable electrical intrusion from the electrodes by strain, leading to a heterogeneous surface structure for more reliable strain sensing characteristics. The strain sensor exhibits decent sensitivity with gauge factor (GF) of ≈8, a moderate sensing range (≈0–35%), and relatively good reliability (3000 stretching cycles). More importantly, by employing a multiclass–multioutput behavior‐learned cognition algorithm, the stretchable sensor array with triangular‐sensor‐assembly exhibits highly accurate recognition of both direction and intensity of an arbitrary strain by interpretating the correlated signals from the three‐unit sensors. The omnidirectional strain perception platform with its neural network algorithm exhibits overall strain intensity and direction accuracy around 98% ± 2% over a strain range of ≈0–30% in various surface stimuli environments.
Mace‐Like Plasmonic Au‐Pd Heterostructures Boost Near‐Infrared Photoimmunotherapy
Authors: Feng Yanlin , Ning Xin , Wang Jianlin , Wen Zhaoyang , Cao Fangfang , You Qing , Zou Jianhua , Zhou Xin , Sun Teng , Cao Jimin , Chen Xiaoyuan 
Published: January 2023

AbstractPhotoimmunotherapy, with spatiotemporal precision and noninvasive property, has provided a novel targeted therapeutic strategy for highly malignant triple‐negative breast cancer (TNBC). However, their therapeutic effect is severely restricted by the insufficient generation of tumor antigens and the weak activation of immune response, which is caused by the limited tissue penetration of light and complex immunosuppressive microenvironment. To improve the outcomes, herein, mace‐like plasmonic AuPd heterostructures (Au Pd HSs) have been fabricated to boost near‐infrared (NIR) photoimmunotherapy. The plasmonic Au Pd HSs exhibit strong photothermal and photodynamic effects under NIR light irradiation, effectively triggering immunogenic cell death (ICD) to activate the immune response. Meanwhile, the spiky surface of Au Pd HSs can also stimulate the maturation of DCs to present these antigens, amplifying the immune response. Ultimately, combining with anti‐programmed death‐ligand 1 (α‐PD‐L1) will further reverse the immunosuppressive microenvironment and enhance the infiltration of cytotoxic T lymphocytes (CTLs), not only eradicating primary TNBC but also completely inhibiting mimetic metastatic TNBC. Overall, the current study opens a new path for the treatment of TNBC through immunotherapy by integrating nanotopology and plasmonic performance.
Nanoreporter for Real‐Time Monitoring of Inflammasome Activity and Targeted Therapy
Authors: Nandi Dipika , Forster James , Ramesh Anujan , Nguyen Anh , Bharadwaj Hariharan , Kulkarni Ashish 
Published: January 2023

AbstractInflammasome activation is associated with a myriad of inflammatory diseases. However, existing methods provides a limited understanding of spatiotemporal kinetics of inflammasome activation, with restricted scope for early detection of associated treatment efficacy. This limitation offers an opportunity for the development of biocompatible in‐vivo inflammasome monitoring tools with translational prospects. To achieve this, they report developing a pair of lipid‐based nanoparticle systems, a reporter nanoparticle consisting of a caspase‐1 activatable probe alone, and a theranostic nanoparticle combining the probe with an inflammasome‐inhibiting drug. This biocompatible platform enhances the probe's residence time in circulation by preventing its opsonization and allowing its sustained release over time. Their results demonstrate the specificity of reporter nanoparticles towards caspase‐1 activity and provides early‐on monitoring of inflammasome activation both in‐vitro as well as in‐vivo. Additionally, the delivery of disulfiram, an inflammasome‐inhibiting drug, along with reporter probe using theranostic nanoparticles enables real‐time tracking of treatment efficacy in the gouty‐arthritis inflammatory model. In summary, they report an unparalleled pair of the inflammasome‐associated reporter and theranostic platforms suited not only for diagnostic applications but can also detect inflammasome‐targeted treatment efficiency in real‐time. These findings establish two novel, sensitive nanotools for non‐invasive evaluation of inflammasome‐targeted immunotherapy.
Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli‐Responsive Cell‐Adhesive Micromaterials
Authors: Kamperman Tom , Willemen Niels G. A. , Kelder Cindy , Koerselman Michelle , Becker Malin , Lins Luanda , Johnbosco Castro , Karperien Marcel , Leijten Jeroen 
Published: January 2023

AbstractEngineered living microtissues such as cellular spheroids and organoids have enormous potential for the study and regeneration of tissues and organs. Microtissues are typically engineered via self‐assembly of adherent cells into cellular spheroids, which are characterized by little to no cell–material interactions. Consequently, 3D microtissue models currently lack structural biomechanical and biochemical control over their internal microenvironment resulting in suboptimal functional performance such as limited stem cell differentiation potential. Here, this work report on stimuli‐responsive cell‐adhesive micromaterials (SCMs) that can self‐assemble with cells into 3D living composite microtissues through integrin binding, even under serum‐free conditions. It is demonstrated that SCMs homogeneously distribute within engineered microtissues and act as biomechanically and biochemically tunable designer materials that can alter the composite tissue microenvironment on demand. Specifically, cell behavior is controlled based on the size, stiffness, number ratio, and biofunctionalization of SCMs in a temporal manner via orthogonal secondary crosslinking strategies. Photo‐based mechanical tuning of SCMs reveals early onset stiffness‐controlled lineage commitment of differentiating stem cell spheroids. In contrast to conventional encapsulation of stem cell spheroids within bulk hydrogel, incorporating cell‐sized SCMs within stem cell spheroids uniquely provides biomechanical cues throughout the composite microtissues’ volume, which is demonstrated to be essential for osteogenic differentiation.
Emerging Epigenetic‐Based Nanotechnology for Cancer Therapy: Modulating the Tumor Microenvironment
Authors: Zhang Jiaxin , Huang Leaf , Ge Guangbo , Hu Kaili 
Published: January 2023

AbstractDysregulated epigenetic modifications dynamically drive the abnormal transcription process to affect the tumor microenvironment; thus, promoting cancer progression, drug resistance, and metastasis. Nowadays, therapies targeting epigenetic dysregulation of tumor cells and immune cells in the tumor microenvironment appear to be promising adjuncts to other cancer therapies. However, the clinical results of combination therapies containing epigenetic agents are disappointing due to systemic toxicities and limited curative effects. Here, the role of epigenetic processes, including DNA methylation, post‐translational modification of histones, and noncoding RNAs is discussed, followed by detailed descriptions of epigenetic regulation of the tumor microenvironment, as well as the application of epigenetic modulators in antitumor therapy, with an emphasis on the epigenetic‐based advanced drug delivery system in targeting the tumor microenvironment.
Synergistic Approach toward Developing Highly Compatible Garnet‐Liquid Electrolyte Interphase in Hybrid Solid‐State Lithium‐Metal Batteries
Authors: Sarkar Subhajit , Chen Bowen , Zhou Chengtian , Shirazi Shahram Nouri , Langer Frederieke , Schwenzel Julian , Thangadurai Venkataraman 
Published: January 2023

AbstractThe hybrid solid‐liquid electrolyte concept is one of the best approaches for counteracting the interface problems between solid electrolytes and Li anodes/cathodes. However, a solid‐liquid electrolyte layer forming at the interfaces degrades battery capacity and power during a longer cycle due to highly reactive chemical and electrochemical reactions. To solve this problem in the present study, a synthetic approach is demonstrated by combining AlCl3 Lewis acid and fluoroethylene carbonate as additives in a conventional LiPF6‐containing carbonate‐based electrolyte. This electrolyte design triggers the fluoroethylene carbonate polymerization by AlCl3 addition and can also form a mechanically robust and ionically conductive Al‐rich interphase on the surface of Li7La2.75Ba0.25Zr1.75Ta0.25O12 garnet‐type structured solid electrolytes, Li anodes and LiNi0.6Mn0.2Co0.2O2 cathodes. Benefitting from this approach, the assembled Li symmetric cell exhibits a remarkably high critical current density of 4.2 mA cm−2, and stable long‐term cycling over 3000 h at 0.5 mA cm−2 at 25 °C. The assembled hybrid full cell shows an impressive specific capacity retention of 92.2% at 1 C till 200 cycles. This work opens a new direction in developing safe, long‐lasting, and high‐energy hybrid solid‐state lithium‐metal batteries.
Stimulating and harnessing circularly polarized luminescence of helically assembled carbonized polymer dots via interfacial dynamics
Authors: Lin Jiaying , Liu Rulin , Chen Peixian , Lv Yangfei , Hao Junjie , Chen Meijuan , Zhang Dongxiang , Pan Ruikun , Li Yiwen , Zhu Xi , He Tingchao , Cheng Jiaji 
Published: January 2023

AbstractStimulating and harnessing circularly polarized luminescence (CPL) is not only a sine qua non for fundamentally unveiling chirogenesis in physical chemistry, but also a pivotal prerequisite for implementation of such phenomenon in research fields including chiral optoelectronics and theranostics. Herein, red‐emissive carbonized polymer dots (CPDs)‐based helical structures were synthesized in this work via biomolecule‐tailored organic–inorganic co‐assembly strategy. The surface states‐related chirality exhibits enhanced circular dichroism (CD) and CPL activities with anisotropic factors as high as gCD,max = 5.4 × 10−3 and glum,max = 1.5 × 10−2, respectively. The obtained CPL signals can be further manipulated in an excitation‐dependent manner, indicating that a synergistic‐competition phenomenon exists between configurational chirality and intermolecular energy‐transfer dynamics, which is further supported by simulations based on density function theory (DFT). Such tunable CPL behavior triggers revolutionary designs and applications of these chiral CPDs into the realm of chirality‐related biological issues and next‐generation chiral optoelectronics.
Atypical chronic myeloid leukemia and myelodysplastic/myeloproliferative neoplasm, not otherwise specified: 2023 update on diagnosis, risk stratification, and management
Authors: Patnaik Mrinal M. , Tefferi Ayalew 
Published: January 2023

AbstractDisease OverviewAtypical chronic myeloid leukemia (aCML) and myelodysplastic/myeloproliferative (MDS/MPN) neoplasms, not otherwise specified (NOS), are MDS/MPN overlap neoplasms characterized by leukocytosis, in the absence of monocytosis and eosinophilia, with <20% blasts in the blood and bone marrow.DiagnosisaCML, previously known as aCML, BCR::ABL1 negative, was renamed as aCML by the ICC classification, and as MDS/MPN with neutrophilia by the 5th edition of the WHO classification. This entity is characterized by dysplastic neutrophilia with immature myeloid cells comprising ≥10% of the white blood cell count, with prominent dysgranulopoiesis. MDS/MPN‐NOS consists of MDS/MPN overlap neoplasms not meeting criteria for defined categories such as chronic myelomonocytic leukemia (CMML), MDS/MPN‐ring sideroblasts‐thrombocytosis (MDS/MPN‐RS‐T), and aCML.Mutations and KaryotypeCytogenetic abnormalities are seen in 40–50% of patients in both categories. In aCML, somatic mutations commonly encountered include ASXL1, SETBP1, ETNK1, and EZH2 whereas MDS/MPN‐NOS can be further stratified by mutational profiles into CMML‐like, MDS/MPN‐RS‐T‐like, aCML‐like, TP35‐mutated, and “others”, respectively.Risk StratificationThe Mayo Clinic aCML model stratifies patients based on age >67 years, hemoglobin <10 g/dl, and the presence of TET2 mutations into low‐risk (0–1 points) and high‐risk (>2 points) groups, with median survivals of 18 and 7 months, respectively. MDS/MPN‐NOS patients have traditionally been risk stratified using MDS risk models such as IPSS and IPSS‐R.TreatmentLeukocytosis and anemia are managed like lower risk MPN and MDS. DNMT inhibitors have been used in both entities with suboptimal response rates. Allogeneic stem cell transplant remains the only curative strategy but is associated with high morbidity and mortality.
Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase
Authors: Messara Amélia , Panossian Armen , Mikami Koichi , Hanquet Gilles , Leroux Frédéric R. 
Published: January 2023

AbstractThe deprotonative functionalization of α,α‐difluoromethyl ketones is described herein. Using a catalytic organosuperbase and a silane additive, the corresponding difluoroenolate could be generated and trapped with aldehydes to deliver various α,α‐difluoro‐β‐hydroxy ketones in high yields. This new strategy tolerates numerous functional groups and represents the access to the difluoroenolate by direct deprotonation of the difluoromethyl unit. The diastereoselective version of the reaction was also investigated withd.r. up to 93 : 7. Several transformations were performed to demonstrate the synthetic potential of these α,α‐difluoro‐β‐hydroxy ketones. In addition, this method has been extended to the use of other electrophiles such as imines and chalcogen derivatives, and a difluoromethyl sulfoxide as nucleophile, thus leading to a diversity of difluoromethylene compounds.
Intense d‐p Hybridization in Nb3O15 Tripolymer Induced the Largest Second Harmonic Generation Response and Birefringence in Germanates
Authors: Chen Kaichuang , Lin Chensheng , Chen Jindong , Yang Guangsai , Tian Haotian , Luo Min , Yan Tao , Hu Zhanggui , Wang Jiyang , Wu Yicheng , Ye Ning , Peng Guang 
Published: January 2023

AbstractWe herein report two asymmetric germanate crystals, KNbGe3O9 and K3Nb3Ge2O13, with different structures and optical properties derived from divergent polymerized forms of GeO4 and NbO6 groups. Remarkably, K3Nb3Ge2O13 achieved a rare combination of the strongest second harmonic generation (SHG) response of 17.5×KDP @ 1064 nm and the largest birefringence of 0.196 @ 546 nm in germanates. It features unique [Nb3O12]∞ tubular chains constructed by circular Nb3O15 tripolymers. Theoretical calculations reveal that the d‐p interactions in the Nb3O15 group are responsible for outstanding optical properties. This work emphasizes the significance of the polymerizable functional units in obtaining high‐performance nonlinear optical (NLO) crystals.
Novel eugenol‐based antimicrobial coatings on aluminium substrates for food packaging applications
Authors: Orlo Elena , Stanzione Mariamelia , Lavorgna Margherita , Isidori Marina , Ruffolo Aldo , Sinagra Ciro , Buonocore Giovanna G. , Lavorgna Marino 
Published: January 2023

AbstractActive packaging systems, interacting directly with the enclosed food, can delay or inhibit those phenomena responsible for food quality decay, contributing to the food shelf‐life extension. In this work a vinyl resin‐based coating containing free or loaded eugenol (EG) in Santa Barbara Amorphous (SBA)15 mesoporous silica nanoparticles is designed to coat flexible aluminium foils to obtain an antimicrobial material. Thermogravimetric analysis shows a good loading capacity of eugenol in SBA15 (48% wt/wt). SEM analysis shows a good dispersion of free EG in the hosting polymeric matrix, whereas some EG/SBA15 particles aggregations are observed in the material. Water contact angle highlights a higher hydrophobicity of the eugenol based‐materials (>90°) compared to the pristine vinyl coating (85°). Electrochemical impedance spectroscopy highlights no corrosion phenomena of the VIN/5%(EG/SBA15EG) coating and corrosion phenomena of the VIN/5%EG coating after 7 days of exposure to lactic acid pH = 4. Finally, the two active coatings are studied to evaluate their antibacterial activity using the ISO 22196. Interestingly, results demonstrate that when eugenol is loaded in the SBA15 mesoporous silica nanoparticles the antimicrobial activity of the material significantly increases against both foodborne pathogens and food spoilage bacteria, achieving the highest microbial growth reduction on S. aureus (R = 3.62 log).