bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of drug-induced sleep endoscopy in Germany—an analysis based on claims data
Authors: Braun M. , Stuck B. A. , Schöbel C. , Steffen A. 
Published: February 2023

Abstract
Background
Drug-induced sleep endoscopy (DISE) has recently gained relevance as a diagnostic tool for obstructive sleep apnea (OSA). However, it is unclear to what extent and in which patient cohorts DISE is used in Germany. With introduction of specific coding for this method in 2021 (Operationen- und Prozedurenschluessel, OPS code), usage can now be analyzed based on diagnosis-related groups (DRG) claims data.

Methods
Aggregated data from all inpatient DISE procedures conducted in German hospitals in 2021 were obtained from the publicly available Institut fuer das Entgeltsystem im Krankenhaus (InEK) database. Patient-relevant information as well as data on hospitals providing the examinations were exported and analyzed.

Results
Between January and December 2021, a total of 2765 DISE procedures were conducted and documented using the newly introduced specific code (1-611.01). Most patients were male (75.6%), in the age categories 30–39 (15.2%) and 40–49 years (17.2%), and presented with the lowest patient clinical complexity level (PCCL; class 0 = 81.88%). Pediatric use was rare (1.8%). Leading main diagnoses of patients were G47.31 (OSA) and J34.2 (deviation of nasal septum). The most common procedures conducted together with DISE were nasal surgery, and the examination was mostly provided in large public hospitals with more than 800 beds.

Conclusion
Though the OSA prevalence in Germany is high, use of DISE as a diagnostic tool is low and represented only 4.4% of cases with a main diagnosis of OSA in 2021. Since specific coding was only introduced in January 2021, trends cannot yet be identified. Noticeable is the frequent combination of DISE with nasal surgery, which is not obviously related to a diagnosis of OSA. Limitations of the study are mainly related to the underlying data, which are available for the inpatient sector only, and due to potentially limited use of the OPS code, which was introduced recently and might not be known to all hospitals.
Services for What and for Whom? A Literature Review of Private Forest Owners’ Decision-Making in Relation to Forest-Based Services
Authors: Matilainen Anne , Andersson Elias , Lähdesmäki Merja , Lidestav Gun , Kurki Sami 
Published: February 2023

AbstractThe more distanced forest owners become from their forests, the more room there is for different kinds of advice and service provision to help them in their forest management decisions. Therefore, the quality and adaptation of these services impact the use of forest resources significantly, including at a broader scale. Even though the forest owners’ decision-making at the general level, as well as the role of advisory services and their efficiency has been the subject of various studies, literature on how forest owners make decisions in relation to the various types of service provisions appears to be limited, and no systematic review has been found. To offer a better understanding of the present state of knowledge on, and the relations between, decision-making, forest related services, and forest ownership, this literature review provides an overview of the scientific research between 2008 and 2020 on private forest owners’ decision-making related to services. The results show that the forest owners’ decision-making related to services has been gaining increasing interest as a research topic, especially during the last 5–6 years. However, it is still dominated by a few countries and contexts. In addition, in the current research decision-making concept is mostly understood as a decision outcome i.e., the forest owners’ choice between typically two alternatives. The importance of process-based understanding on decision-making, on the other hand, seemed to be largely missing from the forest owner studies. As conclusions, five proposals for future research avenues are presented.
Ocular oncology service during the COVID-19 outbreak: uveal melanoma characteristics presenting in 2019 compared to 2020
Authors: Mc Glacken-Byrne Aisling , Murtagh Patrick , O’Neill Valerie , Horgan Noel 
Published: February 2023

Abstract
Aim
We aim to evaluate the impact of the COVID-19 pandemic on ocular oncology in Ireland, comparing uveal melanoma trends in 2019 to 2020.

Methods
Patients included for analysis were those that presented to the ocular oncology service from January 2019 to December 2020 in the Royal Victoria Eye and Ear Hospital in Dublin, who underwent primary treatment for uveal melanoma—proton beam therapy, brachytherapy or enucleation.

Results
Ninety-seven patients presented in 2019 (n = 46) and 2020 (n = 51) who underwent primary treatment for uveal melanoma. Presentation via the eye casualty department was more common in 2020. Dimensions of choroidal melanomas were increased both in basal diameter and thickness compared to those in 2019. More patients had enucleations in 2020 than in 2019 (21.6% vs 9.3%, respectively) and less had proton beam therapy (6.2% vs 12.4%). More patients had evidence of extra-scleral extension at the time of surgery in 2020 compared to 2019 (4.1%, n = 4 versus 0%, respectively). The mean duration of brachytherapy therapy was longer in 2020 (5.3 days ± 35.8) compared to 2019 (4.6 days ± 38.7). Mean time between presentation and primary treatment was 35.6 ± 28.8 days in 2019 and 24.1 ± 20.4 days in 2020.

Conclusions
More advanced disease is suggested by the increased mean basal diameter and tumour thickness, extra-scleral extension and longer duration of brachytherapy. Time from diagnosis to treatment was not delayed in 2020.
Cardiac Involvement in Mitochondrial Disorders
Authors: Popoiu Tudor-Alexandru , Dudek Jan , Maack Christoph , Bertero Edoardo 
Published: February 2023

Abstract

Purpose of Review
We review pathophysiology and clinical features of mitochondrial disorders manifesting with cardiomyopathy.

Recent Findings
Mechanistic studies have shed light into the underpinnings of mitochondrial disorders, providing novel insights into mitochondrial physiology and identifying new therapeutic targets.

Summary
Mitochondrial disorders are a group of rare genetic diseases that are caused by mutations in mitochondrial DNA (mtDNA) or in nuclear genes that are essential to mitochondrial function. The clinical picture is extremely heterogeneous, the onset can occur at any age, and virtually, any organ or tissue can be involved. Since the heart relies primarily on mitochondrial oxidative metabolism to fuel contraction and relaxation, cardiac involvement is common in mitochondrial disorders and often represents a major determinant of their prognosis.
Using Finite Element Modeling in Bone Mechanoadaptation
Authors: Meslier Quentin A. , Shefelbine Sandra J. 
Published: February 2023

AbstractPurpose of the ReviewBone adapts structure and material properties in response to its mechanical environment, a process called mechanoadpatation. For the past 50 years, finite element modeling has been used to investigate the relationships between bone geometry, material properties, and mechanical loading conditions. This review examines how we use finite element modeling in the context of bone mechanoadpatation.Recent FindingsFinite element models estimate complex mechanical stimuli at the tissue and cellular levels, help explain experimental results, and inform the design of loading protocols and prosthetics.SummaryFE modeling is a powerful tool to study bone adaptation as it complements experimental approaches. Before using FE models, researchers should determine whether simulation results will provide complementary information to experimental or clinical observations and should establish the level of complexity required. As imaging technics and computational capacity continue increasing, we expect FE models to help in designing treatments of bone pathologies that take advantage of mechanoadaptation of bone.
Exploring the Use of Artificial Intelligence in the Management of Prostate Cancer
Authors: Chu Timothy N. , Wong Elyssa Y. , Ma Runzhuo , Yang Cherine H. , Dalieh Istabraq S. , Hung Andrew J. 
Published: February 2023

Abstract
Purpose of Review
This review aims to explore the current state of research on the use of artificial intelligence (AI) in the management of prostate cancer. We examine the various applications of AI in prostate cancer, including image analysis, prediction of treatment outcomes, and patient stratification. Additionally, the review will evaluate the current limitations and challenges faced in the implementation of AI in prostate cancer management.

Recent Findings
Recent literature has focused particularly on the use of AI in radiomics, pathomics, the evaluation of surgical skills, and patient outcomes.

Summary
AI has the potential to revolutionize the future of prostate cancer management by improving diagnostic accuracy, treatment planning, and patient outcomes. Studies have shown improved accuracy and efficiency of AI models in the detection and treatment of prostate cancer, but further research is needed to understand its full potential as well as limitations.
Effect of Ultrafiltered Milk on the Rheological and Microstructure Properties of Cream Cheese Acid Gels
Authors: Wu Qihui , Ong Lydia , Yao Shenggen , Kentish Sandra E , Gras Sally L 
Published: February 2023

AbstractThe addition of ultrafiltered (UF) milk retentate is known to impact milk properties during mozzarella and cheddar cheese production, but the effect during cream cheese production is less well understood. Little is known about the impact of UF retentate on the intermediate stages of manufacture, such as protein assembly and the formation of hydrated acid gel structures. Here, milk prepared for cream cheese manufacture using a concentration factor of 2.5 or 5 had a similar particle size distribution to unconcentrated cheese milk after homogenization but increased viscosity and a slower rate of acidification, which could be altered by increasing starter culture concentration. The acid gels formed contained more protein and fat, resulting in a higher storage modulus, firmness, and viscosity. A denser microstructure was observed in acid gels formed with UF retentate addition, and quantitative two- or three-dimensional analysis of confocal images found a greater volume percentage of protein and fat, decreased porosity, and increased coalescence of fat. The mobility of water, as assessed by proton nuclear magnetic resonance, was reduced in the dense UF gel networks. Water movement was partially obstructed, although diffusion was possible between interconnected serum pores. These insights improve our understanding of acid gel formation. They can be used by manufacturers to further optimize the early and intermediate stages of cream cheese production when using concentrated milk to reduce acid whey production and lay the foundation for larger pilot scale studies of intermediate and final cream cheese structure.
The Influence of Follicular Fluid Metals on Assisted Reproduction Outcome
Authors: Rodríguez-Díaz Rubí , Blanes-Zamora Raquel , Paz-Montelongo Soraya , Gómez-Rodríguez Jorge , Fiestas Sonsoles Rodríguez , González-Weller Dailos , Gutiérrez Ángel J. , Rubio Carmen , Hardisson Arturo , Niebla-Canelo Daniel , Vega Samuel Alejandro , González-Dávila Enrique 
Published: February 2023

AbstractInfertility has become more common, with an increased exposure to toxic compounds including heavy metals (HM). Follicular fluid (FF) surrounds the developing oocyte in the ovary and can be analysed to assess metal content. The levels of twenty-two metals were measured in the FF of ninety-three females in a reproduction unit, and their influence on assisted reproduction technique (ART), were examined. The metals were determined by optical emission spectrophotometry. Low values of copper, zinc, aluminium, and calcium favour polycystic ovary syndrome. The relationships between the number of oocytes and metals: iron (rs=0.303; p=0.003) and calcium (rs=−0.276; p=0.007) are significant, as well as between the number of mature oocytes with iron (rs=0.319; p=0.002), calcium (rs=−0.307; p=0.003) and sodium (rs=−0.215; p=0.039) and are near to significance in the case of aluminium (rs=−0.198; p=0.057). In the group with a fertilisation rate ≤ 75%, 36% of the women presented calcium >176.62 mg/kg compared to the group with a fertilisation rate ≥ 75% where this percentage was only 10% (p=0.011). An excess of iron and calcium reduces the good quality embryo rate, and an excess of potassium impairs the blastocyst rate. If potassium is above 237.18 mg/kg and calcium is below 147.32 mg/kg, these conditions favour embryo implantation. Pregnancy is influenced by high potassium and low copper levels. Controlling exposure to toxic elements is recommended for all couples with reduced fertility or receiving an ART.
Inhibition of Vesicular Glutamate Transporters (VGLUTs) with Chicago Sky Blue 6B Before Focal Cerebral Ischemia Offers Neuroprotection
Authors: Pomierny Bartosz , Krzyżanowska Weronika , Skórkowska Alicja , Jurczyk Jakub , Bystrowska Beata , Budziszewska Bogusława , Pera Joanna 
Published: February 2023

AbstractBrain ischemia is one of the leading causes of death and long-term disability in the world. Interruption of the blood supply to the brain is a direct stimulus for many pathological events. The massive vesicular release of glutamate (Glu) after ischemia onset induces excitotoxicity, which is a potent stress on neurons. Loading of presynaptic vesicles with Glu is the first step of glutamatergic neurotransmission. Vesicular glutamate transporters 1, 2, and 3 (VGLUT1, 2, and 3) are the main players involved in filling presynaptic vesicles with Glu. VGLUT1 and VGLUT2 are expressed mainly in glutamatergic neurons. Therefore, the possibility of pharmacological modulation to prevent ischemia-related brain damage is attractive. In this study, we aimed to determine the effect of focal cerebral ischemia on the spatiotemporal expression of VGLUT1 and VGLUT2 in rats. Next, we investigated the influence of VGLUT inhibition with Chicago Sky Blue 6B (CSB6B) on Glu release and stroke outcome. The effect of CSB6B pretreatment on infarct volume and neurological deficit was compared with a reference model of ischemic preconditioning. The results of this study indicate that ischemia upregulated the expression of VGLUT1 in the cerebral cortex and in the dorsal striatum 3 days after ischemia onset. The expression of VGLUT2 was elevated in the dorsal striatum and in the cerebral cortex 24 h and 3 days after ischemia, respectively. Microdialysis revealed that pretreatment with CSB6B significantly reduced the extracellular Glu concentration. Altogether, this study shows that inhibition of VGLUTs might be a promising therapeutic strategy for the future.
Xylose Metabolization by a Saccharomyces cerevisiae Strain Isolated in Colombia
Authors: Lagos Margareth Andrea Patiño , Caviativa Jorge Alejandro Cristancho , Pinzón Diana Carolina Tusso , Roa Diego Hernando Romero , Basso Thiago Olitta , Lozano Mario Enrique Velásquez 
Published: February 2023

AbstractSaccharomyces cerevisiae (S. cerevisiae) is the most widely used yeast in biotechnology in the world because its well-known metabolism and physiology as well as its recognized ability to ferment sugars such as hexoses. However, it does not metabolize pentoses such as arabinose and xylose, which are present in lignocellulosic biomass. Lignocellulose is a widely available raw material, with xylose content of approximately 35% of total sugars. This xylose fraction could be used to obtain high added-value chemical products such as xylitol. One of these yeasts isolated from a Colombian locality, designated as 202-3, showed interesting properties. 202-3 was identified through different approaches as a strain of S. cerevisiae, with an interesting consumption of xylose metabolizing into xylitol, in addition with excellent ability as a hexose fermenter with high ethanol yields and shows resistance to inhibitors present in lignocellulosic hydrolysates. The xylose metabolization by the 202-3 strain and their kinetics parameters had not been previously reported for any other natural strain of S. cerevisiae. These results suggest the great potential of natural strains for obtaining high value-added chemical products using sugars available in lignocellulosic biomass.
The Future of the Monograph in the Arts, Humanities and Social Sciences: Publisher Perspectives on a Transitioning Format
Authors: Shaw Philip , Phillips Angus , Gutiérrez Maria Bajo 
Published: February 2023

AbstractA web-based survey of academic publishers was undertaken in 2021 by a team at Oxford International Centre for Publishing into the state of monograph publication in the arts, humanities, and social sciences. 25 publishing organisations responded, including many of the larger presses, representing approximately 75% of monograph output. Responses to the survey showed that the Covid 19 pandemic has accelerated the existing trend from print to digital dissemination and that Open Access (OA) titles receive substantially greater levels of usage than those published traditionally. Responses also showed that for most publishers OA publication stands at under 25% of output and that fewer than 10% of authors enquire about OA publication options. Continuing problem areas highlighted by respondents were the clearing of rights for OA publication and the standardisation of title and usage metadata. All responding organisations confirmed that they expect to be publishing monographs in ten years’ time, but that they anticipate the format and/or the model will be different, with open access expected to play a key part in the future, perhaps in the context of a mixed economy of OA and ‘toll access’ publication.
Constructions of Sexual Identities in the Ageing Body: A Qualitative Exploration of Older Norwegian Adults’ Negotiation of Body Image and Sexual Satisfaction
Authors: Schaller Sidsel Louise , Kvalem Ingela Lundin , Træen Bente 
Published: February 2023

AbstractOlder adults face age-related changes as well as stigma in relation to their bodies and sexuality, challenging their understanding of themselves as sexual, thought to impact both sexual desire, activity and satisfaction. A qualitative study with a semi-structured interview was completed with 32 people, aged 65–85, to investigate how older people construct understanding of their self as sexual in an ageing body. The analysis generated two main themes; “Positions of the ageing body as sexual”, with three subthemes, and “Negotiating change, transitions in identities”, with two sub themes. Results showed variations in participants’ thoughts about their body and how either appearance, agency or body function influenced different aspects of current sexuality and sexual satisfaction, and understandings of self. Statements showed examples of both internalized ageist understandings of the ageing body as sexual, but also rejections or low relevance of ageist attitudes in the understandings of present body image and sexual satisfaction. Results showed differences in how changes were understood and negotiated either through enhancement strategies or through cognitive-emotional, and social regulation. The findings demonstrated paradoxes and contradictions in the understanding and management of the ageing body and sexual satisfaction, where variations were found along but also across the divides of gender, relationship status and quality, sexual orientation, self-esteem and age cohorts. Implications indicate that health care strategies and policies should understand sexual ageing from a developmental perspective to support individual projects of developing affirmative and adjusted identities as sexual in an ageing body.
Cyberbullying during COVID-19 lockdowns: prevalence, predictors, and outcomes for youth
Authors: António Raquel , Guerra Rita , Moleiro Carla 
Published: February 2023

AbstractThe COVID-19 pandemic posed additional challenges to the safety and well-being of young people who were forced to engage in online learning, spending more time than ever online, and cyberbullying emerged as a notable concern for parents, educators, and students. Two studies conducted online examined the prevalence, predictors, and outcomes of cyberbullying episodes during the lockdowns due to the outbreak of COVID-19 in Portugal. Study 1 (N = 485) examined the prevalence of cyberbullying among youth during the first lockdown period in 2020, focusing on predictors, symptoms of psychological distress and possible buffers of the effects of cyberbullying. Study 2 (N = 952) examined the prevalence of cyberbullying, predictors, and symptoms of psychological distress during the second lockdown period in 2021. Results revealed that most participants experienced cyberbullying, symptoms of psychological distress (e.g., sadness and loneliness) during the lockdowns were higher for those who experienced than for those who did not experience cyberbullying, and those who experienced cyberbullying with higher levels of parental and social support showed lower levels of symptoms of psychological distress (i.e., suicidal ideation). These findings contribute to the existing knowledge on online bullying among youth, specifically during COVID-19 lockdowns.
Analysis of music-exposure interventions for impacting prosocial behaviour via behaviour change techniques and mechanisms of action: a rapid review
Authors: Grimani Aikaterini , Moog Alexander , Vlaev Ivo 
Published: February 2023

AbstractThe aim of the study is to evaluate the interventions examining music exposure’s effects on prosocial behaviour, to identify the behaviour change techniques (BCTs) through which they change it, and to examine the mechanisms of action (MoAs) that mediate the relationship between music exposure and prosocial behaviour. The review identified 15 research articles, comprising 19 relevant studies. The results revealed that, though many of the included studies did not provide enough information to code them adequately, the BCTs “Instruction on how to perform a behaviour”, “Salience of consequences”, “Reduce negative emotions” and “Identification of self as role model” were the most commonly utilized techniques. Additionally, “Emotion” was the most significant MoA in the intervention-behaviour relationship in this context, but too few BCTs were able to be coded to make conclusions about any BCT-MoA relationships.
Combined tumor necrosis factor-α (−308 G/A) and tumor necrosis factor-β (+ 252 A/G) nucleotide polymorphisms and chronicity in Egyptian children with immune thrombocytopenia
Authors: El-Ghamrawy Mona , El-Gharbawi Nesrine , Shahin Gehan , Abdelhady Alaa , Sayed Rasha , Diaa Nehal , Bishai Irene 
Published: February 2023

Abstract
Background
Primary immune thrombocytopenia (ITP) is a common autoimmune disorder. Secretion of TNF-α, TNF-β and IFN-γ plays a major role in the pathogenesis of ITP.

Objective
This cross-sectional study aimed to detect TNF-α (−308 G/A) and TNF-β (+ 252 A/G) gene polymorphism in a cohort of Egyptian children with chronic ITP (cITP) to clarify their possible association with progression to chronic disease.

Methods
The study included 80 Egyptian cITP patients and 100 unrelated age- and sex-matched controls. Genotyping was performed using polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP).

Results
Patients with TNF-α homozygous (A/A) genotype had significantly higher mean age, longer disease duration and lower platelet counts (p values 0.005, 0.024 and 0.008, respectively). TNF-α wild (G/G) genotype was significantly more frequent among responders (p = 0.049). Complete response was more frequent among wild (A/A) TNF-β genotype patients (p = 0.011), and platelet count was significantly lower among homozygous (G/G) genotype (p = 0.018) patients. Combined polymorphisms were strongly associated with susceptibility to chronic ITP.

Conclusion
Homozygosity in either gene might contribute to a worse course of disease, increased severity and poor response to therapy. Patients expressing combined polymorphisms are more prone to progression to chronic disease, severe thrombocytopenia and longer disease duration.