bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mismatch novelty exploration training shifts VPAC1receptor mediated modulation of hippocampal synaptic plasticity by endogenous VIP in male rats
Authors: Aidil-Carvalho F , Caulino-Rocha A , Ribeiro JA , Cunha-Reis D 
Published: December 2022

AbstractNovelty influences hippocampal-dependent memory through metaplasticity. Mismatch novelty detection activates the human hippocampal CA1 area and enhances rat hippocampal-dependent learning and exploration. Remarkably, mismatch novelty training (NT) also enhances rodent hippocampal synaptic plasticity. Inhibition of VIP interneurons by prefrontal cortex GABAergic projections promotes rodent exploration. Since VIP, acting on VPAC1receptors (Rs), restrains hippocampal LTP and depotentiation by modulating disinhibition we now investigated the impact of NT on VPAC1modulation of hippocampal synaptic plasticity in male Wistar rats. NT enhanced both CA1 hippocampal LTP and depotentiation unlike exploring an empty holeboard (HT) or a fixed configuration of objects (FT). Blocking VIP VPAC1Rs with PG 97-269 (100nM) enhanced both LTP and depotentiation in naïve animals but this effect was less effective in NT rats. Altered endogenous VIP modulation of LTP was absent in animals exposed to the empty environment (HT). HT and FT animals showed mildly enhanced synaptic VPAC1R levels but neither VIP nor VPAC1R levels were altered in NT animals. Conversely, NT enhanced the GluA1/GluA2 AMPAR ratio and gephyrin synaptic content but not PSD-95 excitatory synaptic marker. In conclusion, NT influences hippocampal synaptic plasticity by reshaping brain circuits modulating disinhibition and its control by VIP-expressing hippocampal interneurons while upregulation of VIP VPAC1Rs is associated to maintenance of VIP control of LTP in FT and HT animals. This suggests VIP receptor ligands may be relevant to co-adjuvate cognitive recovery therapies in aging or epilepsy, where LTP/LTD imbalance occurs.Significance statementThis work sheds light into the contribution of hippocampal neuropeptide VIP and VIP containing GABAergic neurons on the reformulation of hippocampal circuit communication leading to altered synaptic plasticity responses upon training in repeated exposure to object mismatch novelty as compared with routine training paradigms with and without objects. Although still far from the clinic, the results suggest that VIP receptor ligands may be useful to co-adjuvate cognitive stimuli therapies based on these aspects of novelty, aiming at the cognitive rescue of aged individuals or epilepsy patients, that show impaired capacity in novelty induced adaptations of cognitive function.Graphical abstract
Mechanism of LLPS of SARS-CoV-2 N protein
Authors: Dang Mei , Li Tongyang , Song Jianxing 
Published: December 2022

AbstractSARS-CoV-2 nucleocapsid (N) protein with low mutation rate is the only structural protein not only functioning to package viral genomic RNA, but also manipulating the host-cell machineries, thus representing a key target for drug development. Recent discovery of its liquid-liquid phase separation (LLPS) not only sheds light on previously-unknown mechanisms underlying the host-SARS-CoV-2 interaction and viral life cycle, but most importantly opens up a new direction for developing anti-SARS-CoV-2 strategies/drugs. However, so far the high-resolution mechanism of LLPS of N protein still remains unknown because it is not amenable for high-resolution biophysical investigations. Here we systematically dissected N protein into differential combinations of domains followed by DIC and NMR characterization. We successfully identified N (1-249), which not only gives high-quality NMR spectra, but phase separates as the full-length N protein. The results together decode for the first time: 1) nucleic acid modulates LLPS by dynamic but specific interactions multivalently over both folded NTD/CTD and Arg/Lys residues within IDRs. 2) ATP, mysteriously with concentrations >mM in all living cells but absent in viruses, not only specifically binds NTD/CTD, but also Arg residues within IDRs with Kd of 2.8 mM. 3) ATP dissolves LLPS by competitively displacing nucleic acid from binding the protein. Therefore, ATP and nucleic acid interplay in modulating LLPS by specific competitions for binding over the highly overlapped binding sites. Our study deciphers the mechanism of LLPS of N protein, which is targetable by small molecules. ATP is not only emerging as a cellular factor controlling the host-SARS-CoV-2 interaction, but also provides a lead for developing anti-SARS-CoV-2 drugs efficient for different variants of SARS-CoV-2. Fundamentally, our results imply that the mechanisms of LLPS of IDR-containing proteins mediated by ATP and nucleic acids appear to be highly conserved from human to virus.
Examining the slow acceptance of HR analytics in the Indian engineering and construction industry: a SEM-ANN-based approach
Authors: Arora Meenal , Prakash Anshika , Mittal Amit , Singh Swati 
Published: December 2022

PurposeDespite the extensive benefits of human resource (HR) analytics, the intention to adopt such technology is still a matter of concern in the engineering and construction sectors. This study aims to examine the slow adoption of HR analytics among HR professionals in the engineering and construction sector.Design/methodology/approachA cross-sectional online survey including 376 HR executives working in Indian-based engineering and construction firms was conducted. Hierarchal regression, structural equation modeling and artificial neural networks (ANN) were applied to evaluate the relative importance of HR analytics predictors.FindingsThe results reveal that hedonic motivation (HM), data availability (DA) and performance expectancy (PE) influence the behavioral intention (BI) to use HR analytics, whereas effort expectancy (EE), quantitative self-efficacy (QSE), habit (HA) and social influence (SI) act as barriers to its adoption. Moreover, PE was the most influential predictor of BI.Practical implicationsBased on the findings of this study, engineering and construction industry managers can formulate strategies for the implementation and promotion of HR analytics to enhance organizational performance.Originality/valueThis study draws attention to evidence-based decision-making, emphasizing barriers to the adoption of HR analytics. This study also emphasizes the concept of DA and QSE to enhance adoption among HR professionals, specifically in the engineering and construction industry.
Brand systems: integrating branding research perspectives
Authors: Padela Shoaib M. Farooq , Wooliscroft Ben , Ganglmair-Wooliscroft Alexandra 
Published: December 2022

Purpose
This paper aims to conceptualise and characterise brand systems and outline propositions and research avenues to advance the systems’ view of branding.

Design/methodology/approach
A conceptual synthesis approach is adopted to integrate the extant branding research perspectives. The conceptual framework is grounded in the theoretical foundation of marketing systems theory.

Findings
The conceptual framework delineates brand inputs, throughputs, outcomes and feedback effects within a brand system. It configures the complexity and dynamics of brand value formation among brand actors within the branding environment.

Research limitations/implications
This paper contributes to systems thinking in branding and brand value co-creation research. It extends marketing systems theory into the branding context and provides research directions for exploring the structural and functional configurations, cause–consequence processes and outcome concerns of brand value formation.

Practical implications
This conceptual framework informs brand development, management and regulation at a macro level. Managers can apply the brand system concept to identify and manage conflicting expectations of brand actors and alleviate adverse brand outcomes such as negative brand externalities, enhancing overall brand system health and societal value.

Originality/value
This research expands the scope of brand actor agency and identifies the likelihood of disproportionate brand outcomes. It provides methodological guidelines for analysis and intervention in brand systems.
The effects of major earthquakes on the labor market: evidence from Turkey
Authors: Dolu Aslı , İkizler Hüseyin 
Published: December 2022

PurposeThe purpose of this paper is to explore the impact of earthquakes on the labor market. The authors try to estimate the impact of two major earthquakes (Izmir and Elazig) in Turkey.Design/methodology/approachIn order to analyze the effects of devastating earthquakes in the nearby regions of the province where the earthquake took place, on the labor market, monthly and annual data from the TUIK and ISKUR database will be used. For this purpose, the authors consider the earthquake a natural experiment and employ a Synthetic Control Method (SCM). In addition, the analysis will be carried out using seasonally adjusted data, taking into account the seasonal effects of the monthly data to be used in the study.FindingsThe results show that the impact varies based on the labor market structure of the regions. While the earthquake positively affects the labor market of agriculture-oriented regions, it harms the labor market of nonagricultural-oriented regions.Research limitations/implicationsA major limitation of the study is that we cannot fully separate the impact of Covid-19 from our estimate. The authors believe that Covid-19 overestimates the negative impact of earthquakes on the labor market.Social implicationsEarthquakes have adverse effects on the labor market. The estimation of the earthquake-related costs may provide a useful guide on policy planning and government incentives.Originality/valueThe originality of the study lies in the fact that this is the first study to evaluate how the dynamics of the labor market has changed as a result of the earthquakes that have taken place in Turkey, within the framework of causality.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-08-2022-0568
Virtual gifting behavior on new social media: the perspectives of the community gift-giving model and face-negotiation theory
Authors: Hsieh Jung-Kuei , Kunz Werner H. , Wu Ai-Yun 
Published: December 2022

PurposeThis study aims to investigate the factors that affect an audience's purchase decisions on a new type of social media, namely live video streaming platforms.Design/methodology/approachThis study is based on data from an online survey providing 488 valid responses. These responses are used to test the research model by employing partial least squares (PLS) modeling.FindingsThree antecedents (consumer competitive arousal, gift design aesthetics and broadcaster's image) influence the audience's purchase decisions (impulse buying and continuous buying intention). Chinese impression management (mianzi) acts as a moderator.Self-mianzi,mutual mianziandother mianzi(i.e. three subtypes ofmianzi) moderate the effects of consumer competitive arousal, gift design aesthetics and broadcaster's image on impulse buying.Practical implicationsThe findings encourage practitioners developing marketing strategies for live video streaming platforms in the Chinese cultural context to consider peer influence, gift appearance, broadcaster's image andmianzi.Originality/valueDrawing on the community gift-giving model and face-negotiation theory, this study provides an integrated research model to investigate a new type of social media (live video streaming). It offers insight into virtual gifting behaviors by confirming the effects of three antecedents on the audience's purchase decisions, withmianziacting as a moderator.
Determinants of online professor reviews: an elaboration likelihood model perspective
Authors: Li Yaojie , Wang Xuan , Van Slyke Craig 
Published: December 2022

PurposeDrawing on the elaboration likelihood model (ELM), the authors examine the influence of perceived professor teaching qualities, as central cues, on online professor ratings. Also, our study investigates how the volume and period of reviews, as peripheral cues, affect online professor ratings.Design/methodology/approachLeveraging stratified random sampling, the authors collect reviews of 892 Information Systems professors from 250 American universities. The authors employ regression models while conducting robustness tests through multi-level logistic regression and causal inference methods.FindingsOur results suggest that the central route from perceived professor qualities to online professor ratings is significant, including most qualitative pedagogical factors except positive assessment. In addition to course difficulty, the effect of the peripheral route is limited due to deficient diagnosticity.Research limitations/implicationsOur primary concern about the data validity is a lack of a competing and complementary dataset. However, an institutional evaluation survey or an experimental study can corroborate our findings in future research.Practical implicationsOnline professor review sites can enhance their perceived diagnosticity and credibility by increasing review vividness and promoting site interactivity. In addition to traditional institutional evaluations, professors can obtain insightful feedback from review sites to improve their teaching effectiveness.Originality/valueTo our best knowledge, this study is the first attempt to employ the ELM and accessibility-diagnosticity theory in explicating the information processing of online professor reviews. It also sheds light on various determinants and routes to persuasion, thus providing a novel theoretical perspective on online professor reviews.
Integrating Green Lean Six Sigma and industry 4.0: a conceptual framework
Authors: Kaswan Mahender Singh , Rathi Rajeev , Cross Jennifer , Garza-Reyes Jose Arturo , Antony Jiju , Yadav Vishwas 
Published: December 2022

PurposeThis research aims to propose a framework to integrate Green Lean Six Sigma (GLSS) and Industry 4.0 to improve organizational sustainability.Design/methodology/approachThe integration of GLSS and Industry 4.0 is proposed based on theoretical facets of the individual approaches. A generic, conceptual framework of an integrated GLSS-Industry 4.0 approach is then proposed using the application of different tools and techniques of GLSS and Industry 4.0 at different stages of the realization of a project.FindingsBoth approaches have common facets related to enablers and barriers, and the integrated application of tools and techniques of each approach supplements the common focus of both related to sustainability enhancement. The proposed, conceptual framework provides systematic guidelines from the project selection stage to the sustainment of the solution, with the enumerated application of different techniques and tools at each step of the framework.Originality/valueThis research is the first of its kind to propose the integration of GLSS and Industry 4.0 under the umbrella of a unified approach, including a conceptual framework of this integrated GLSS-Industry 4.0 approach.
Energy-conserving cryptocurrency response during the COVID-19 pandemic and amid the Russia–Ukraine conflict
Authors: Mnif Emna , Mouakhar Khaireddine , Jarboui Anis 
Published: December 2022

PurposeThe mining process is essential in cryptocurrency networks. However, it consumes considerable electrical energy, which is undoubtedly harmful to the environment. In response, energy-conserving cryptocurrency projects with reduced energy requirements or based on renewable energies have been developed. Recently, the COVID-19 pandemic and the Russian invasion of Ukraine ignited an unprecedented upheaval in financial products, especially in cryptocurrency and energy markets. Therefore, the paper aims to explore the response of these energy-conserving cryptocurrencies to the COVID-19 pandemic and the Russia–Ukraine conflict.Design/methodology/approachThis paper investigates the response of these energy-conserving cryptocurrencies to the COVID-19 pandemic and the Russia–Ukraine conflict. Their competitiveness is compared with conventional ones by analyzing their efficiency through multifractal detrended fluctuation analysis and automatic variance ratio during the COVID-19 and Russian invasion periods.FindingsThe empirical results show that all investigated energy-conserving cryptocurrencies negatively responded to the pandemic and positively reacted to the Russian invasion. On the other hand, all conventional cryptocurrencies reacted negatively to the COVID-19 pandemic and the amid-Russian attack. Besides, Bitcoin and SolarCoin were the least inefficient before the outbreak of COVID-19. Nevertheless, the Ethereum market became the most efficient after the pandemic spread. Similarly, the efficiency of Ripple was the most significant during the conflict between Russia and Ukraine. The energy crisis caused by Russia benefited the efficiency of the studied energy-conserving cryptocurrencies.Practical implicationsThis research is of interest to investors seeking opportunities in these energy-conserving cryptocurrencies and policymakers working to implement reforms to improve their market efficiency and promote long-term financial market growth.Originality/valueTo the best of the authors' knowledge, the behavior of cryptocurrencies based on renewable and reduced energy during the recent conflict between Russia and Ukraine has not been explored.
Work from home amid black swan event (Covid-19): a bibliometric analysis from a social science perspective
Authors: Dogra Prinka , Parrey Aubid Hussain 
Published: December 2022

PurposeThis paper aims to facilitate researchers, practitioners and policymakers in understanding and managing the impact of the black swan event – COVID-19 on work from home in the social science subject area through bibliometric analysis. For this purpose, the authors analyzed publications from the Scopus database.Design/methodology/approachIn this paper, the authors conducted bibliometric analysis based on two major techniques: performance analysis and science mapping. The authors applied VOSviewer and Biblioshiny to address the research questions of present study. The study explored the hot trend topics and summarized them with discussions and implications.FindingsBased on the analysis of 500 publications, the authors present an overview of performance and science mapping from the perspective of different aspects such as publication output and authors. Also, authors visualized the text mining by co-word analysis forming nine clusters as well as mapping trend topics. The existing publications were divided into ten clusters according to different keyword analyses: Leadership, Mental health, Technology, Crisis Management, Gender, Challenges, well-being and Work-life balance.Research limitations/implicationsSample from the Scopus database is not exhaustive, and the dataset may be skewed due to the adoption of the selection criteria. The authors’ concentration was on academic publications in English that excludes potentially intriguing and pioneering studies done in other languages. The study area was limited to social science only.Practical implicationsThe paramount lesson is that the COVID-19 quandary is multifaceted, necessitating not simply adaptations to current strategies but also an understanding and analysis of advancements in the economy, commerce and society. According to the analysis presented above, to overcome the COVID-19 “black swan event”, managers must think ahead. The analysis gives leaders and decision-makers a range of useful information on work from home (WFH) difficulties in COVID-19, as well as initiatives and revisions that must be implemented at the economic, social and scientific aspects when dealing with such uncertainties. The findings also aid managers in forecasting the need for sophisticated technology, organizational agility and resilience to attain the desired direction of progress.Originality/valueWith a focus on addressing WFH during COVID-19 from social science perspective and to synthesize its future research directions systematically, the authors performed Bibliometric analysis both with VOSviewer and Biblioshiny, in order to enhance the overall analysis for higher accuracy and more reliable results that is unique value addition and contribution to the existing literature.
Critical success factors of lean in the public services sector: the case of the Greek citizen's service centers
Authors: Keramida Efthalia , Psomas Evangelos L. , Antony Jiju 
Published: December 2022

PurposeThe aim of this study is to determine the most critical success factors (CSFs) of lean adoption in a specific Greek public services subsector namely citizen's service centers (CSCs) and to define their underlying structure (latent constructs).Design/methodology/approachIn this study an online structured questionnaire survey was distributed to all the Greek CSCs and six hundred and seventy-two employees responded and fully completed the questionnaire. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were applied to assess the reliability and validity of the latent constructs of the Lean CSFs.FindingsData analysis revealed that the latent constructs of the lean CSFs, namely communication, top management commitment and leadership, organizational culture, training and education, change and project management, availability of resources, teamwork, and employee involvement and empowerment are of major importance for the adoption of lean in the CSCs.Research limitations/implicationsThe small percentage of the responding employees of the Greek CSCs, given their large population and the subjective nature of the data collected constitute the main limitations of the present study.Practical implicationsThe findings of this research can guide managers and decision makers of CSCs in recognizing the key factors that potentially will influence the successful adoption of lean, and the enhancement of the quality management initiatives of these services organizations. Moreover, the formulated model can also serve as a reference for academics and researchers to generate new research ideas. Finally, the results may offer guidelines to managers of public services organizations of other countries with a similar structure of the public sector.Originality/valueThe present study is stimulated by the existing gap identified in the literature in the field of the public sector. Building on the public sector literature, this is the first study that evaluates the importance of the CSFs of lean in the Greek CSCs and defines their underlying structure.