bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective and preliminary observation of cardiovascular responses to the head-up tilting test in patients with over 1-year follow-up after coronary artery bypass grafting
Authors: Hori Shinnosuke , Nishimura Yoshiharu , Kamijo Yoshi-ichiro , Minami Kohei , Umemoto Yasunori , Yokoyama Mao , Mikami Yukio , Nishimura Yukihide , Ogawa Takahiro , Tajima Fumihiro 
Published: January 2023

Abstract
Hori et al. have suggested previously that blood pressure during a head-up tilt (HUT) in a patient after CABG at discharge was likely to decrease, even they took exercise therapy. Medication status after CABG and reduced stroke volume, one of index for blood volume, would be related with it. On the other hand, some natural adaptations to orthostatic stress in the patients may be expected over long-term recovery. However, there was no study to assess blood pressure during HUT after CABG while monitoring medication status and stroke volume over a long period. Changes in cardiovascular responses to HUT in 6 patients were preliminarily tested during supine and 15-min 60°HUT before (P0) and after coronary artery bypass grafting (CABG) (P1) and over 1-year after surgery (P2). Mean arterial pressure (MAP) decreased during HUT at P0 and P1 and the decrease at P1 was greater than P0, while it remained unchanged at P2. Heart rate (HR) increased during HUT at P0 and P1 and the increase at P1 tended to be greater than P0, while that at P2 were comparable to P0. Stroke volume (SV) was 30% lower during baseline at P1 and P2 than P0. Cardiac output reduced by HUT at P0, but was not affected at P1 and P2, while the baseline at P2 was lower than P0. Ejection fraction remained unchanged at 3 periods. In conclusion, baseline SV at P2 remained lower than P0, but MAP was maintained during HUT. The present results suggest that although the poor control of blood pressure just after is improved over 1 year after CABG, hypovolemia might not be corrected. Assessments of an exercise regimen over long term after CABG would be expected in the future.
WITHDRAWN: Predictive value of neutrophil-to-lymphocyte ratio in mortality of critically ill patients with atrial fibrillation: a retrospective analysis of the Medical Information Mart for Intensive Care IV Database
Authors: Ma Ruicong , Chen Yucheng , Zhang Guolin , Ding Yanchun 
Published: January 2023

Abstract

Objective
Inflammation plays an important role in the occurrence and development of atrial fibrillation. We aim to explore the predictive value of neutrophil-to-lymphocyte ratio (NLR) in mortality of critically ill patients with atrial fibrillation (AF).
Methods
The data of this retrospective cohort study was collected from the MIMIC-IV database. Patients were divided into four groups according to NLR level (cut-off: 7.26) and whether they were diagnosed with AF. The primary outcome of our study was in-hospital mortality. Secondary outcomes included 30-day mortality, 90-day mortality, and 1-year mortality. Restricted cubic spline curve to show the relationship between NLR and in-hospital mortality. Cox Survival analysis and cox regression models were used to assess the association between NLR and mortality.
Results
A total of 20,707 patients were eligible for analysis. Restricted cubic spline curve showed that NLR level was associated with the lowest risk of in-hospital mortality was 7.26 in all patients, 7.22 in non-AF patients and 7.67 in AF patients. Cox Survival analysis curves showed that patients with AF combined with high-level NLR (Group 4) had higher all-cause mortality compared with other groups. The results of multivariate analysis showed that high NLR was an independent risk factor for poor prognosis in AF patients. The association was consistent among patients in different ICU types.
Conclusions
Critically ill patients with AF comorbidity and elevated levels of NLR had higher risks of mortality. Moreover, high NLR was an independent risk factor for poor prognosis in AF patients. However, further prospective studies are still needed to reveal this relationship.
MCL-DTI: Using Drug Multimodal Informationand Bi-directional Cross-Attention Learningmethod for Predicting Drug-Target Interaction
Authors: Qian Ying , Wu Jian , Zhang Qian 
Published: January 2023

Abstract
Background: Prediction of drug-target interaction (DTI) is an essential step fordrug discovery and drug reposition. Traditional methods are mostlytime-consuming and labor-intensive, and deep learning-based methods addressthese limitations and are applied to engineering. Most of the current deeplearning methods employ representation learning of unimodal information such as SMILES sequences, molecular graphs, or molecular images of drugs. In addition,most methods focus on feature extraction from drug and target alone withoutfusion learning from drug-target interacting parties, which may lead toinsufficient feature representation.
Results: To enhance feature learning between drugs and targets, we propose anovel model based on deep learning for DTI task called MCL-DTI which usesmultimodal information of drug and learn the representation of drug-targetinteraction for drug-target prediction. In order to further explore a morecomprehensive representation of drug features, this paper first exploits twomultimodal information of drugs, molecular image and chemical text, to representthe drug. We also introduce to use bi-rectional multi-head corss attention (MCA)method to learn the interrelationships between drugs and targets. Thus, we buildtwo decoders, which include an multi-head self attention (MSA) block and anMCA block, for cross-information learning. We use a decoder for the drug andtarget separately to obtain the interaction feature maps. Finally, we feed thesefeature maps generated by decoders into a fusion block for feature extraction andoutput the prediction results.
Conclusions: MCL-DTI achieves the best results in all the three datasets:Human, C.elegans and Davis, including the balanced datasets and an unbalanceddataset. The results on the drug-drug interaction (DDI) task show that MCL-DTIhas a strong generalization capability and can be easily applied to other tasks.
Attitudes of Nursing Students Towards’ Ethical Values. Comparative study in two country
Authors: Lesińska-Sawicka Małgorzata , Kızılırmak Aynur 
Published: January 2023

Abstract
Background
Ethical values are a guideline for behavior in certain situations. They take on particular importance in patient care. Ethical values depend on many factors including culture.
Objective
The aim of the study is to compare the attitudes of nursing students from different countries towards ethical values.
Design:
A cross-sectional study design was used.
Methods
The aim of this study is to compare the attitudes of nursing students towards ethical values. 463 students participated in the survey, including 191 from Poland and 272 from Turkiye. The study was conducted from April to June 2022. For the purposes of this study was used Ethical Values Scale (IEVS). The criteria for excluding participants from the study were nursing student status and consent to participate in the study.
Results
The IEVE total score for all respondents was 68.20 and the median was 68. In the individual subscales: Love-Respect 34.76 (median 35), Justice-Honesty 21.29 (median 21) and Cooperation 12.14 (median 12). Polish students' total IEVS score average was 70.48 ± 6.81 and Turkish students' IEVS total score average was 66.61 ± 9.65. There is a statistically significant difference between the total score average on the IEVS of students from the two countries (p < 0.001).
Conclusion
The formation of ethical attitudes among students should be strengthened, paying attention to their cultural conditions. Research should be continued, expanding to include other socio-cultural factors.
Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease activated receptor-2
Authors: Hennes Aurélie , Devroe Johanna , De Clercq Katrien , Ciprietti Martina , Held Katharina , Luyten Katrien , Ranst Nele Van , Maenhoudt Nina , Peeraer Karen , Vankelecom Hugo , Voets Thomas , Vriens Joris 
Published: January 2023

Abstract

Background:Early embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive endometrium. Embryo development and endometrial receptivity must be synchronized and an adequate two-way dialogue between them is necessary for maternal recognition and implantation. Proteases have been described as blastocyst-secreted proteins involved in the hatching process and early implantation events. These enzymes stimulate intracellular calcium signaling pathways in endometrial epithelial cells. However, the exact molecular players underlying protease-induced calcium signaling, the subsequent downstream signaling pathways and the biological impact of its activation remain elusive.Methods:To identify gene expression of the receptors and ion channels of interest in human and mouse endometrial epithelial cells, RNA sequencing, RT-qPCR andin situhybridization experiments were conducted. Calcium microfluorimetric experiments were performed to study their functional expression.Results:We showed that trypsin evoked intracellular calcium oscillations in EEC of mouse and human, and identified the protease-activated receptor 2 (PAR2) as the molecular entity initiating protease-induced calcium responses in EEC. In addition, this study unraveled the molecular players involved in the downstream signaling of PAR2 by showing that depletion and re-filling of intracellular calcium stores occurs via PLC, IP3R and the STIM1/Orai1 complex. Finally,in vitroexperiments in the presence of a specific PAR2 agonist evoked an upregulation of the pre-decidualization response in human endometrial epithelial cells.Conclusions:These findings provide new insights into the blastocyst-derived protease signaling and allocate a key role for PAR2 as maternal sensor for signals released by the developing blastocyst.
Interaction of Depressive Status and Cognitive Ability Predicts Psychological Resilience of Young Adults in Taiwan
Authors: Lin Szu-Hung , Huang Tzu-Yun , Liao Yu-Chi , Wu Chia-Huei , Hsieh Shulan , Yang Cheng-Ta 
Published: January 2023

Abstract

Associations among cognitive ability, depressive symptoms, and psychological resilience have been found, but the interaction among these variables remains unclear, especially for young adults. The current study aimed to investigate how these variables interact in young adults in Taiwan. A total of 192 participants (97 female) with a mean age of 21.84 years (range 19–30 years) were analyzed for this study. Participants’ cognitive ability was assessed by the Taiwanese version of the Montreal Cognitive Assessment. Depressive status was evaluated by the revision of Beck Depression Inventory-II. Participants with a score of 14 or above were defined as mild-to-severe-depressed (MSD). Otherwise, they were defined as minimal-depressed (MD). For the psychological resilience measurement, a Chinese version of the Resilience Scale for Adults (RSA) was used. A linear regression model was applied to investigate the interaction of cognitive ability and depressive status on psychological resilience after adjusting for the covariates of gender and age. The interaction of BDI-II and MoCA was significantly associated with the RSA score (B = -6.519, p = .044) and other effects were not significant. The results indicated that a negative relationship between cognitive ability and psychological resilience was only observed in MSD young adults but not in MD. This study had a limited number of participants in the MSD group. Young adults with higher cognitive ability reported lower psychological resilience when they had mild-to-severe depression. In contrast, cognitive ability does not relate to psychological resilience among young adults with minimal depression.
The sustainability of lean implementations at the hospitals of Ministry of Health Malaysia: a study protocol
Authors: Lum Kah Yee , Putera Ku Anis Shazura binti Indera , Krishnan Muniamal , Libasin Zalina binti , Abdullah Nur Nadia Renu binti , Saman@Saimy Intan Syafinaz binti 
Published: January 2023

Abstract
Background
In Malaysia, lean was initiated in 2012 as part of an effort to reduce waiting time at the Ministry of Health (MOH) hospitals. As of now, there are 52 public hospitals that have officially implemented lean however these hospitals have demonstrated difficulties in sustaining it. In addition, monitoring on the progress and maintenance of lean within the MOH are based on performance indicators that prove inadequate in indicating whether lean is sustaining. Therefore, this study protocol aims to fill the gap by (i) identifying the critical success factors (CSFs) for lean sustainability in the MOH and using it to (ii) develop a validated framework to support hospitals in sustaining lean (iii) the framework will be adapted into a measurement tool in the form of checklist to measure the level of lean sustainability (iv) interview hospitals with the lowest and highest level of lean sustainability to further explore the barriers and boosters in sustaining lean
Methods
This study will employ a mixed-method approach and will be conducted in three phases. The first phase involves a combination of scoping review and interviews with key informants to identify the CSFs known to affect lean sustainability at the MOH hospitals and the findings will be presented in a validated framework. In the second phase, the framework will then be converted into a checklist to measure the level of lean sustainability in the MOH hospitals. Results from the second phase will subsequently be used to select the hospital with the lowest and highest level of lean sustainability for a further interview in the third phase.
Discussion
The findings from this study will benefit policymakers and lean practitioners involved in evidence-based lean implementations in the MOH. The developed lean sustainability framework will be able to provide more relevant guidance on how to increase the likelihood of lean sustainability and serves as a validated measurement tool for MOH hospitals. In addition, this study will be able to outline the differences in the contributing factors between health organizations that showed a high level of lean sustainability compared to those struggling to sustain.
A Framework for Energy-saving Selection and Scheduling of Equipment Resources in a Networked Manufacturing Environment
Authors: Zhou Lirong , Wang Yue , Liu Peiji , Deng Wei , Kong Ling , Wang Guangcun , Xie Xun 
Published: January 2023

Abstract

Improving the energy efficiency of manufacturing industry is a globally common choice to pursue sustainable development and achieve the goals of carbon peak and carbon neutrality. Networked manufacturing is a new business model formed under enterprise informatization. Networked manufacturing mode has some environmental characteristics that affect its energy saving potential, for example machining devices are numerous and scattered, manufacturing services are driven by customer orders, and significant random uncertainty occurs in manufacturing processes. This paper proposes a framework for equipment resource energy-saving selection and scheduling in networked manufacturing environment, mainly including: 1) Developing a fuzzy multi-objective decision-making model that takes into account economy, energy consumption, technology, and inter-enterprise collaboration, in pursuit of the selection of machining devices and logistics equipment to increase energy efficiency during the customer orders demand stage; 2) Establishing an energy-saving scheduling model for equipment resources based on non-cooperative game theory to meet the diverse needs of customers, that can balance the competitive interests between customer orders, and reduce manufacturing energy consumption, costs, and delivery dates in manufacturing tasks implementation stage; 3) In order to deal with random disturbance in the networked manufacturing, a scheduling model for equipment resources based on random chance constraint programming is built to optimize energy, economy, and production efficiency at the preventive stage of manufacturing tasks change; 4) A cloud platform implementation method of the proposed framework is briefly summarized. The framework plays common theoretical analysis that is significant to energy-saving allocation of the equipment resources in networked manufacturing.
Piezo1/ERK signaling pathway is activated in aortic VSMCs of patients with aortic dissection or aneurysm
Authors: Zhang Hong , Cao Wenxuan , Zhuang Yingzhu , Zhang Hui , Hu Haoyu , Shi Chunying , Yang Sumin 
Published: January 2023

Abstract
Background
Piezo1 in vascular smooth muscle cells(VSMCs) is sensitive to the change of hemodynamic pressure and play the specific biological roles. ERK may be the key potential downstream signal of Piezo1. However, it remains unknown whether Piezo1/ERK signaling can be activated in aortic VSMCs of patients with aortic dissection(AD) or aneurysm(AA).
Methods
Piezo1 and p-ERK protein expressions were compared between AD/AA human aortic samples and normal samples by western blotting analysis and Immunohistochemistry. In addition, the rat thoracic VSMCs were divided into control, Yoda1( Piezo1 agonist), sch772984(ERK inhibitor) and Yoda1 + sch772984 groups. The cell life activities, including cell proliferation, migration, apoptosis, autophagy and phenotypical switch were measured.
Results
The patients with AD/AA had higher blood pressure than that of donors. We found that the expressions of Piezo1 and p-ERK in aortic media of AD/AA were higher than normal samples. In vitro experiments showed that Piezo1 could induce cell proliferation and migration by evoking ERK signaling, and this effect can be blocked by sch772984.
Conclusions
Piezo1/ERK signaling pathway is significantly activated in aortic VSMCs of patients with AD/AA, which might participate in AD/AA via promoting VSMCs proliferation and migration. This study provides a new insight into the biological action of Piezo1/ERK signaling pathway in the pathogenesis of AD/AA.
Nurses’ Humanistic Care Behaviour in China: A Cross-sectional Survey
Authors: Zhang Yi , Chen Xing , Chen Xi , Luo Jiang , Chen Zhangqun , Gan Ting , Zeng Liting , Wang Jianjian , Zhao Liping 
Published: January 2023

Abstract
Background
More attention has been focused on the development of nurses' humanistic care behavior during the COVID-19 outbreak in China. However, its level is unknown.
Method
A cross-sectional study was conducted with an online questionnaire administered in August 2020. Descriptive statistics and binary logistics regression analyses were conducted using the SPSS 26.0.
Results
The total score of nurses' humanistic care behaviour is 117.59 ± 22.434. Different genders, age, marital status, nursing ages, professional titles, and attention degrees of hospital humanities have a varied impact on the nurses' humanistic care behaviour (p < 0.05). The binary logistic regression model was statistically significant (p < 0.01).
Conclusion
This study reported the level and influencing factors of caring behavior among Chinese nurses and provided evidence-based strategies to improve its level.
Toxicity Study of a New Scale Inhibitor for Seawater Desalination
Authors: Duan Lian , Li Yimin , Gu Wen , Wang Chao , Shi Ying , Yang Hongbin , Wang Mengmeng , Long Yuehan , Tang Song , Kong Jian , Zhang Shaoping , Zhang Lixia , Wei Lei , Wang Chong , Lu Kai 
Published: January 2023

Abstract
Maleic acid polymer scale inhibitor is a new domestic seawater desalination scale inhibitor. Guided by the Organization for Economic Cooperation and Development method, this study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this new inhibitor. The LD50 obtained from the acute oral toxicity test was 6810 and 9260 mg/kg·BW for male and female rats, as well as 1/5, 1/10 and 1/20 LD50 were as the dose for sub-chronic toxicity test. It showed the weight of male rats with high dose was significantly lower than the control group during the exposure period (p<0.05), and the food consumption in the first 4 weeks was lower than the control group (p_week1 = 0.0261, p_week4 = 0.00222). The blood biochemical results showed the UREA in the medium- and high-dose groups were significantly higher than the control group (p_ female medium = 0.0047, p_high = 0.0037; p_male medium= 0.0026, p_ high<0.001), and increased as a dose dependence. Based on UREA results, the NOAEL and LOAEL were 1/20 LD50 and 1/10 LD50, respectively (males: 340.5 and 170.25 mg/kg·BW, females: 436 and 231.5 mg/kg·BW). Comet assay in vitro and Mammalian Erythrocyte Micronucleus Test were jointly to judge genotoxicity. This inhibitor did not cause chromosome aberrations in mouse bone marrow cells. However, the tail moment of CHO cell in all groups (p<0.01) and the DNA% in tail in the 1/4 IC50 and IC50 groups were higher than the negative control (p<0.001) in comet assay, suggesting the potential DNA damage in CHO cell. The oral LD50 and the NOAEL and LOAEL obtained in this study provides a theoretical basis for further toxicity research and risk assessment.
Integrated analyses of single-cell and bulk transcriptome reveal cell type-specific metastasis- and prognosis-related genes in breast cancer
Authors: Dong Jiahan , Li Congjun 
Published: January 2023

Abstract
Background
Single-cell technologies raise the possibility of providing type-specific insights into tumor microenvironment and facilitate the development of personalized medicine. The object of this research was to afford a novel means to explore the cell type-specific differentially expressed genes (DEGs) between primary cancer and metastatic lymph nodes which were also utilized to investigate the potentials of clinical practice.
Methods
We collected single-cell and bulk transcriptome sequencing data from two public databases. With single-cell data, we explored the cell type-specific DEGs between primary cancer and metastatic lymph nodes. Also, the cell type-specific DEGs among different states through single-cell pseudotime analysis were identified as the potential genes cardinal for cell differentiation. With the intersection DEGs and bulk transcriptome sequencing data, we further delineated the therapeutic potentials of these DEGs through identification of a prognostic signature which could be used to facilitate the stratification of patients with different outcomes. We also investigated the different cell communication patterns between primary cancer and metastatic lymph nodes.
Results
We identified 2177 cell type-specific DEGs between primary cancer and metastatic lymph nodes. We further identified 2330 cell type-specific DEGs among different states through single-cell pseudotime analysis. The intersection DEGs were incorporated into bulk transcriptome sequencing data, with which we constructed a signature comprising of eight genes and validated it using an independent cohort. The samples with high-risk also exhibited low levels of immune infiltration compared to high-risk samples. The cell interactions in metastatic lymph nodes were mainly downregulated except macrophage migration inhibitory factor (MIF) signal pathway.
Conclusion
The cell type-specific DEGs identified though single-cell data might be the potential therapeutic targets. The robust signature could be used to predict outcomes of patients especially in combination with conventional TNM stages. We also demonstrated the benefits of immune infiltration in breast cancer. The exclusive MIF signal pathway in metastatic lymph nodes might be correlated with the metastasis and deserved more studies.