bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of exercise and antioxidant supplementation on cellular lipid peroxidation in elderly individuals: Systematic review and network meta-analysis
Authors: Ni Chunxia , Ji Yiyi , Hu Keke , Xing Kai , Xu Yining , Gao Yanan 
Published: February 2023

Background: The viewpoints of previous studies on the correlation between exercise and cellular lipid peroxidation are contradictory from many perspectives and lack evidence for elder individuals. A new systematic review with network meta-analysis is necessary and will have significant practical value to provide high-quality evidence in the development of exercise protocols and an evidence-based guide for antioxidant supplementation for the elderly.Aims: To identify the cellular lipid peroxidation induced by different types of exercise, with or without antioxidant supplementation, in elderly individuals.Methods: Randomized controlled trials that recruited elderly participants and reported cellular lipid peroxidation indicators and were published in peer-reviewed journals in English were searched by a Boolean logic search strategy and screened in the databases PubMed, Medline, Embase, and Web of Science. The outcome measures were the biomarkers of oxidative stress in cell lipids in urine and blood, namely F2-isoprostanes, hydrogen peroxide (LOOH, PEROX, or LIPOX), malondialdehyde (MDA), and thiobarbituric acid reactive substances (TBARS).Result: 7 trials were included. A combination program of aerobic exercise (AE), low-intensity resistance training (LIRT), and a placebo intake (Placebo) and a combination program of aerobic exercise, low-intensity resistance training, and antioxidant supplementation (S) had the most and sub-most potential to dampen cellular lipid peroxidation (AE + LIRT + Placebo: 0.31 in Rank 1 and 0.2 in Rank 2; AE + LIRT + S: 0.19 in Rank 1 and 0.20 in Rank 2); A placebo intake (Placebo) and a blank intervention without exercise (NE) had the most and sub-most potential to induce an enhancement of cellular lipid peroxidation (Placebo: 0.51 in Rank 9 and 0.16 in Rank 8; NE: 0.16 in Rank 9 and 0.28 in Rank 8). All included studies had an unclear risk of selecting reporting. There were no high confidence ratings in all the direct and indirect comparisons, 4 comparisons in the direct evidence structure and 7 comparisons in the indirect evidence structure had moderate confidence.Conclusion: A combined protocol consisting of aerobic exercise and low-intensity resistance training is recommended to dampen cellular lipid peroxidation. Extra antioxidant supplementation might be unnecessary if an elderly individual has enough aerobic and resistance exercise.Systematic Review Registration: CRD42022367430
High-mobility group box 1 protein, receptor for advanced glycation end products and nucleosomes increases after marathon
Authors: Schoenfeld Julia , Roeh Astrid , Holdenrieder Stefan , von Korn Pia , Haller Bernhard , Krueger Kimberly , Falkai Peter , Halle Martin , Hasan Alkomiet , Scherr Johannes 
Published: February 2023

Background: Prolonged and strenuous exercise has been linked to potential exercise-induced myocardial damages. One potential key to unmask the discussed underlying mechanisms of this subclinical cardiac damage could be markers of immunogenic cell damage (ICD). We investigated the kinetics of high-mobility group box 1 protein (HMGB1), soluble receptor for advanced glycation end products (sRAGE), nucleosomes, high sensitive troponin T (hs-TnT) and high sensitive C-reactive protein (hs-CRP) before and up to 12 weeks post-race and described associations with routine laboratory markers and physiological covariates.Methods: In our prospective longitudinal study, 51 adults (82% males; 43 ± 9 years) were included. All participants underwent a cardiopulmonary evaluation 10–12 weeks pre-race. HMGB1, sRAGE, nucleosomes, hs-TnT and, hs-CRP were analysed 10–12 weeks prior, 1–2 weeks before, immediately, 24 h, 72 h, and 12 weeks post-race.Results: HMGB1, sRAGE, nucleosomes and hs-TnT increased significantly from pre- to immediately post-race (0.82–2.79 ng/mL; 1132–1388 pg/mL; 9.24–56.65 ng/mL; 6–27 ng/L; p &lt; 0.001) and returned to baseline within 24–72 h. Hs-CRP increased significantly 24 h post-race (0.88–11.5 mg/L; p &lt; 0.001). Change in sRAGE was positively associated with change in hs-TnT (rs = 0.352, p = 0.011). Longer marathon finishing time was significantly associated with decreased levels of sRAGE [−9.2 pg/mL (β = −9.2, SE = 2.2, p &lt; 0.001)].Conclusion: Prolonged and strenuous exercise increases markers of ICD immediately post-race, followed by a decrease within 72 h. An acute marathon event results in transient alterations of ICD, we assume that this is not solely driven by myocyte damages.
The relationship between intolerance of uncertainty, coping style, resilience, and anxiety during the COVID-19 relapse in freshmen: A moderated mediation model
Authors: Wang Ting , Jiang Lingwei , Li Tiantian , Zhang Xiaohang , Xiao Sanrong 
Published: February 2023

BackgroundThe repeated outbreaks of COVID-19 and the rapid increase in uncertainty have had many negative effects on the public’s mental health, especially on emotional aspects such as anxiety and depression. However, in previous studies, there are few studies exploring the positive factors between uncertainty and anxiety. The innovation of this study is the first to explore the mechanism of coping style and resilience as people’s psychological protective factors between uncertainty and anxiety caused by the COVID-19 pandemic.MethodsThis study explored the relationship between intolerance of uncertainty and anxiety of freshmen with coping style as mediating variable and resilience as moderating variable. A total of 1049 freshmen participated in the study and completed the Intolerance of Uncertainty Scale (IUS-12), Self-rating Anxiety Scale (SAS), Simplified Coping Style Questionnaire (SCSQ), and Connor-Davidson Resilience Scale (CD-RISC).ResultsSAS score of the surveyed students (39.56 ± 10.195) was significantly higher than that of the Normal Chinese score (29.78 ± 10.07, p &lt; 0.001). Intolerance of uncertainty was significantly positively correlated with anxiety (β = 0.493, p &lt; 0.001). Positive coping style has a significant negative impact on anxiety (β = −0.610, p &lt; 0.001), negative coping style has a significant positive impact on anxiety (β = 0.951, p &lt; 0.001). Resilience moderates the second half of the influence of negative coping style on anxiety (β = 0.011, t = 3.701, p &lt; 0.01).ConclusionThe findings suggest that high levels of intolerance of uncertainty had negative effects mental burden during the COVID-19 pandemic. The knowledge of the mediating role of coping style and the moderating role of resilience may be used by health care workers when consulting freshmen with physical health complaints and psychosomatic disorders.
Predictive potential of somatic symptoms for the identification of subthreshold depression and major depressive disorder in primary care settings
Authors: Li Xiuwen , Zhang Huimin , Han Xue , Guo Lan , Ceban Felicia , Liao Yuhua , Shi Jingman , Wang Wanxin , Liu Yifeng , Song Weidong , Zhu Dongjian , Wang Hongqiong , Li Lingjiang , Fan Beifang , Lu Ciyong , McIntyre Roger S. 
Published: February 2023

BackgroundThe presence of heterogenous somatic symptoms frequently obscures the recognition of depression in primary care. We aimed to explore the association between somatic symptoms and subthreshold depression (SD) and Major Depressive Disorder (MDD), as well as to determine the predictive potential of somatic symptoms in identifying SD and MDD in primary care.MethodsData were derived from the Depression Cohort in China study (ChiCTR registry number: 1900022145). The Patient Health Questionnaire-9 (PHQ-9) was used to assess SD by trained general practitioners (GPs), and the Mini International Neuropsychiatric Interview depression module was used to diagnose MDD by professional psychiatrists. Somatic symptoms were assessed using the 28-item Somatic Symptoms Inventory (SSI).ResultsIn total of 4,139 participants aged 18–64 years recruited from 34 primary health care settings were included. The prevalence of all 28 somatic symptoms increased in a dose-dependent manner from non-depressed controls to SD, and to MDD (P for trend &lt;0.001). Hierarchical clustering analysis grouped the 28 heterogeneous somatic symptoms into three clusters (Cluster 1: energy-related symptoms, Cluster 2: vegetative symptoms, and Cluster 3: muscle, joint, and central nervous symptoms). Following adjustment for potential confounders and the other two clusters of symptoms, per 1 increase of energy-related symptoms exhibited significant association with SD (OR = 1.24, 95% CI, 1.18–1.31) and MDD (OR = 1.50, 95% CI, 1.41–1.60) The predictive performance of energy-related symptoms in identifying individuals with SD (AUC = 0.715, 95% CI, 0.697–0.732) and MDD (AUC = 0.941, 95% CI, 0.926–0.963) was superior to the performance of total SSI and the other two clusters (P &lt; 0.05).ConclusionsSomatic symptoms were associated with the presence of SD and MDD. In addition, somatic symptoms, notably those related to energy, showed good predictive potential in identifying SD and MDD in primary care. The clinical implication of the present study is that GPs should consider the closely related somatic symptoms for early recognition for depression in practice.
Association of coffee consumption pattern and metabolic syndrome among middle-aged and older adults: A cross-sectional study
Authors: Nina Ren , Lingling Huang , Qiushuang Li , Honglin Guo , Liyuan Sun , Yuting Zhang 
Published: February 2023

ObjectivesThe association between coffee consumption and the risk of metabolic syndrome (MetS) remains inconsistent. The aim of this study was to evaluate the association between coffee intake and components of MetS.MethodA cross-sectional survey including 1,719 adults was conducted in Guangdong, China. Data on age, gender, education level, marriage status, body mass index (BMI), current smoking and drinking status and breakfast habit, coffee consumption type, and daily servings were derived based on 2-day, 24-h recall. MetS were assessed according to the International Diabetes Federation definition. Multivariable logistic regression was conducted to examine the association between the coffee consumption type, daily servings, and the components of MetS.ResultsRegardless of the coffee type, compared with non-coffee consumers, coffee consumers had higher odds ratios (ORs) of the elevated fasting blood glucose (FBG) in both men [OR: 3.590; 95% confidence intervals (CI): 2.891–4.457] and women (OR: 3.590; 95% CI: 2.891–4.457). In women, the risk of elevated blood pressure (BP) was 0.553 times (OR: 0.553; 95% CI: 0.372–0.821, P = 0.004) for people who drank total coffee &gt; 1 serving/day than for non-coffee drinkers.ConclusionIn conclusion, regardless of type, coffee intake is associated with an increased prevalence of FBG in both men and women, but has a protective effect on hypertension only in women.
Axes of social inequities in COVID-19 clinical trials: A systematic review
Authors: Ponjoan Anna , Jacques-Aviñó Constanza , Medina-Perucha Laura , Romero Victor , Martí-Lluch Ruth , Alves-Cabratosa Lia , Ramos Rafel , Berenguera Anna , Garcia-Gil María del Mar 
Published: February 2023

ObjectiveThe representativeness of participants is crucial to ensure external validity of clinical trials. We focused on the randomized clinical trials which assessed COVID-19 vaccines to assess the reporting of age, sex, gender identity, race, ethnicity, obesity, sexual orientation, and socioeconomic status in the results (description of the participants' characteristics, loss of follow-up, stratification of efficacy and safety results).MethodsWe searched the following databases for randomized clinical trials published before 1st February 2022: PubMed, Scopus, Web of Science, and Excerpta Medica. We included peer-reviewed articles written in English or Spanish. Four researchers used the Rayyan platform to filter citations, first reading the title and abstract, and then accessing the full text. Articles were excluded if both reviewers agreed, or if a third reviewer decided to discard them.ResultsSixty three articles were included, which assessed 20 different vaccines, mainly in phase 2 or 3. When describing the participants' characteristics, all the studies reported sex or gender, 73.0% race, ethnicity, 68.9% age groups, and 22.2% obesity. Only one article described the age of participants lost to follow-up. Efficacy results were stratified by age in 61.9%, sex or gender in 26.9%, race and/or, ethnicity in 9.5%, and obesity in 4.8% of the articles. Safety results were stratified by age in 41.0%, and by sex or gender in 7.9% of the analysis. Reporting of gender identity, sexual orientation or socioeconomic status of participants was rare. Parity was reached in 49.2% of the studies, and sex-specific outcomes were mentioned in 22.9% of the analysis, most of the latter were related to females' health.ConclusionsAxes of social inequity other than age and sex were hardly reported in randomized clinical trials that assessed COVID-19 vaccines. This undermines their representativeness and external validity and sustains health inequities.
Pre-pandemic physical activity as a predictor of infection and mortality associated with COVID-19: Evidence from the National Health Insurance Service
Authors: Park Saengryeol , Kim Hyeseong , Park So-Youn , Oh In-Hwan 
Published: February 2023

IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, many populations have experienced reduced physical activity (PA) levels, weight gain, and increased anxiety and depression. However, according to a previous study, engaging in PA has a positive effect on damages caused by COVID-19. Therefore, this study aimed to investigate the association between PA and COVID-19 using the National Health Insurance Sharing Service Database in South Korea.MethodsLogistic regression analysis was used to analyze the association of PA with COVID-19 and mortality. The analysis was adjusted for body mass index, sex, age, insurance type, comorbidity, and region of residence at baseline. Disability and lifestyle (weight, smoking, and drinking status) were adjusted consecutively.ResultsThe results indicated that engaging in insufficient PA as per the WHO guidelines predicts a higher risk of COVID-19 when controlling for personal characteristics, comorbidity, lifestyle, disability, and mortality.DiscussionThis study revealed the need to engage in PA and manage weight to reduce the risk of infection and mortality associated with COVID-19. Because engaging in PA is an important component of weight management and can help restore physical and mental health after the COVID-19 pandemic, it should be emphasized as a pillar of recovery after COVID-19.
Clinical-pathological features and perioperative outcomes of mediastinoscopy vs. thoracoscopy esophagectomy in esophageal cancer: A meta-analysis
Authors: Gong Sheng , Rao Xin , Yuan Ye , Yao Xiaojun , Li Gang , Wang Ning , Li Dan , Jiang Liangshuang 
Published: February 2023

ObjectiveTo compare the clinicopathological features and perioperative outcomes of video-assisted mediastinoscopy esophagectomy (VAME) compared to video-assisted thoracoscopy esophagectomy (VATE) in esophageal cancer.MethodsWe comprehensively searched online databases (PubMed, Embase, Web of Science and Wiley online library) to find available studies exploring the clinicopathological features and perioperative outcomes between VAME and VATE in esophageal cancer. Relative risk (RR) with 95% confidence interval (CI) and standardized mean difference (SMD) with 95% CI were used to evaluate the perioperative outcomes and clinicopathological features.ResultsA total of seven observational studies and one randomized controlled trial involving 733 patients were considered eligible for this meta-analysis, of which 350 patients underwent VAME in contrast to 383 patients underwent VATE. Patients in the VAME group had more pulmonary comorbidities (RR = 2.18, 95% CI 1.37–3.46, P = 0.001). The pooled results showed that VAME shortened the operation time (SMD = −1.53, 95% CI −2.308–−0.76, P = 0.000), and retrieved less total lymph nodes (SMD = −0.70, 95% CI −0.90–−0.50, P = 0.000). No differences were observed in other clinicopathological features, postoperative complications or mortality.ConclusionsThis meta-analysis revealed that patients in the VAME group had more pulmonary disease before surgery. The VAME approach significantly shortened the operation time and retrieved less total lymph nodes and did not increase intra- or postoperative complications.
Effect of oral administration of gabapentin on the minimum alveolar concentration of isoflurane in cats
Authors: Chen Hangbin , Yang Huan , Li Mengqing , Peng Haojie , Guo Weibin , Li Meng 
Published: February 2023

ObjectiveTo determine if oral gabapentin decreases the minimum alveolar concentration (MAC) of isoflurane in cats.Study designProspective, randomized, blinded, crossover, and experimental study.AnimalsA total of six healthy adult cats (three male, three female) aged 18–42 months, weighing 3.31 ± 0.26 kg.MethodsCats were randomly given oral gabapentin (100 mg cat−1) or placebo 2 h before starting MAC determination, with the crossover treatment given at least 7 days apart. Anesthesia was induced and maintained with isoflurane in oxygen. Isoflurane MAC was determined in duplicate using an iterative bracketing technique and tail clamp method. Hemodynamic and other vital variables were recorded at each stable isoflurane concentration and were compared between gabapentin and placebo treatments at lowest end-tidal isoflurane concentration when cats did not respond to tail clamping. A pairedt-test was used to compare normally distributed data, and a Wilcoxon signed-rank test was applied for non-normally distributed data. Significance was set atp&lt; 0.05. Data are mean ± standard deviation.ResultsIsoflurane MAC in the gabapentin treatment was 1.02 ± 0.11%, which was significantly lower than that in the placebo treatment (1.49 ± 0.12%;p&lt; 0.001), decreasing by 31.58 ± 6.94%. No significant differences were found in cardiovascular and other vital variables between treatments.Conclusion and clinical relevanceOral administration of gabapentin 2 h before starting MAC determination had a significant isoflurane MAC-sparing effect in cats with no observed hemodynamic benefit.
PENGAMBILAN TITANIUM DIOKSIDA (TiO2) DARI PASIR BESI KULONPROGO MENGGUNAKAN METODE HIDROMETALURGI (VARIASI KONSENTRASI DAN SUHU)
Authors: Grasella Florency Giovanni Saefeto  , Sri Rahayu Gusmarwani  
Published: February 2023

Pasir besi merupakan bahan alam yang ketersediannya sangat melimpah di Indonesia. pasir besi berada pada urutan ke empat terbanyak unsur yang membentuk bumi. Menurut hasil penelitian Indreswari Suroso Kandungan titanium pada pasir besi sebesar 12.87%. Hidrometalurgi merupakan Ilmu yang mempelajari cara memperoleh logam dari sumbernya pada bumi. Proses pelindian (leaching) adalah proses pemekatan kimiawi untuk melepaskan pengotor bijih dari suatu mineral dengan cara pelarutan dalam reagen tertentu.
Pada tahapan penelitian hal pertama yang harus dilakukan yaitu preparasi pasir besi dengan mengunakan magnet, kemudian proses dekomposisi dimana hasil separasi pasir besi dihomogenisasikan dengan NaoH kemudian difurnace pada suhu 550oC. selanjutnya dilakukan proses pemisahan larutan dengan padatan yang dimana padatan tersebut akan dikeringkan menggunakan oven pada suhu 110oC. dan tahapan terakhir yaitu pelindian.
Pada hasil preparasi dan proses dekomposisi didapatkan hasil hasil yaitu besi merupakan unsur utama pada pasir besi karena memiliki kandungan terbesar yaitu Fe (44.07%) dan yang memiliki kandungan terkecil yaitu Mn (0.726%). Kandungan titanium pada pasir besi yang telah diseparasi sebesar 4.618%.
Hasil pada jurnal yang telah direview menunjukan bahwa untuk mendapatkan hasil ekstrak titanium dan untuk mengetahui kandungan dalam titanium dapat menggunakan beberapa metode antara lain hidrometalurgi (leaching), peleburan, pemanasan gelombang mikro, dekomposisi dan pelindian, Hidrolisis, elektrolisis, kausik, dan sonokimia.
Dari metode tersebut didapatkan hasil kandungan titanium yang terdapat pada pasir besi dan bahan baku lainnya yaitu pada hidrometalurgi (leaching) didapatkan 12.2 % dan 6.51%, peleburan 5.71%, pemanasan gelombang mikro 5.89%, dekomposisi dan pelindian 5.33 %, Hidrolisis 45.35%, elektrolisis 4.22%, kausik 19.94 %, dan sonokimia.8.27 %
PEMANFAATAN KULIT JAGUNG DAN TONGKOL JAGUNG (Zea Mays) SEBAGAI BAHAN DASAR PEMBUATAN KERTAS SENI DENGAN PENAMBAHAN NATRIUM HIDROKSIDA (NaOH) (Variabel Konsentrasi NaOH dengan Waktu Pemasakan)
Authors: Rahmat Fikri  , Murni Yuniwati  
Published: February 2023

Limbah kulit dan tonkol jagung banyak dijumpai setelah paska panen dan hanya dibuang oleh masyarakat, akan menyebabkan pencemaran lingkungan jika tidak ditangani. Limbah kulit dan tongkol jagung merupakan tanaman yang dapat digunakan sebagai bahan dasar pembuatan kertas seni, yang memiliki kandungan selulosa tinggi.
Kertas seni dalam penelitian ini dibuat dari kulit jagung dan tongkol jagung. Penelitian ini dilakukan Laboratorium Proses Kimia Institut Sains & Teknologi Akprind Yogyakarta. Penelitian dilakukan dengan menggunakan variable konsentrasi NaOH dan waktu pemasakan.
Proses pembuatan kertas seni diawali dengan pencucian, pemotongan, serta pengeringan kulit dan tongkol jagung. Pencucian berfungsi membersihkan kotoran yang menempel pada kulit dan tongkol jagung. Pemotongan berfungsi mempermudah proses pemasakan. Pengeringan berfungsi agar kandungan air dalam kulit dan tongkol jagung semakin rendah. Pemasakan dilakukan dengan menggunkan larutan NaOH konsentrasi yang ditentukan. Setelah itu dicuci, menggunakan aquadest sampai pH netral. Penggilingan pulp (blender) dengan penambahan lem PVAc dan garam (NaCl), kemudian dilakukan pencetakan dan pengeringan kertas dibawah sinar matahari. Setelah kertas kering kemudian dianalisis untuk mengetahui kuat sobek, kuat tarik dari kertas seni berbahan dasar kulit dan tongkol jagung dengan penambahan NaOH.
Berdasarkan penelitian diperoleh kondisi proses yang terbaik dengan menggunakan konsentrasi NaOH 4% dan waktu pemasakan 80 menit. Dengan kondisi proses tersebut diperoleh kadar alfa selulosa 83,33%, kuat sobek 6,36 mN, dan kuat tarik 5,73 MPa.
Penguatan Moderasi Beragama Berbasis Keluarga melalui Bimbingan Pra-Nikah bagi Calon Pengantin
Authors: Nurasiah Yayah 
Published: February 2023

Moderasi beragama atau sikap moderat dalam beragama secara umum merupakan sebuah proses untuk memahami sekaligus mengamalkan ajaran agama secara adil dan seimbang. Memahami dan mengamalkan agama secara adil dan seimbang dalam keluarga berguna agar pasangan yang sudah menikah dapat terhindar dari perilaku yang dapat merusak kehormatan dan martabat keluarga. Salah satu penguatan meoderasi agama berbasis keluarga yang bimbingan pranikah. Pendekatan yang dilakukan dalam penelitian ini yaitu pendekatan kualitatif dengan menggunakan metode studi kepustakaan. Hasil penelitian menunjukan bahwa cara pandang dan sikap moderat dalam beragama sangat penting bagi masyarakat. Terutama jika hal tersebut dimulai dari keluarga. Ada beberapa materi yang sangat penting untuk penguatan moderasi beragama dalam keluarga, diantaranya: toleransi, kepemimpinan dalam keluarga, pembagian peran dalam keluarga, relasi berkualitas antara kepala dan anggota rumah tangga, membudayakan musyawarah dalam pengambilan keputusan.