bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcutaneous Immunoglobulin 16.5% (Cutaquig®) in Primary Immunodeficiency Disease: Safety, Tolerability, Efficacy, and Patient Experience With Enhanced Infusion Regimens
Authors: Gupta Sudhir , DeAngelo James , Melamed Isaac , Walter Jolan E. , Kobayashi Ai-Lan , Bridges Tracy , Sublett J. Wesley , Bernstein Jonathan A. , Koterba Alan , Manning Michael , Maltese Joanna , Hoeller Sonja , Turpel-Kantor Eva , Kreuwel Huub , Kobayashi Roger H. 
Published: March 2023

Abstract
Purpose
To achieve reductions in infusion time, infusion sites, and frequency, a prospective, open-label, multicenter, Phase 3 study evaluated the safety, efficacy, and tolerability of subcutaneous immunoglobulin (SCIG) 16.5% (Cutaquig®, Octapharma) at enhanced infusion regimens.
Methods
Three separate cohorts received SCIG 16.5% evaluating volume, rate, and frequency: Cohort 1) volume assessment/site: up to a maximum 100 mL/site; Cohort 2) infusion flow rate/site: up to a maximum of 100 mL/hr/site or the maximum flow rate achievable by the tubing; Cohort 3) infusion frequency: every other week at twice the patient’s weekly dose.
Results
For Cohort 1 (n = 15), the maximum realized volume per site was 108 mL/site, exceeding the currently labeled (US) maximum (up to 40 mL/site for adults). In Cohort 2 (n = 15), the maximum realized infusion flow rate was 67.5 mL/hr/site which is also higher than the labeled (US) maximum (up to 52 mL/hr/site). In Cohort 3 (n = 34), the mean total trough levels for every other week dosing demonstrated equivalency to weekly dosing (p value = 0.0017). All regimens were well tolerated. There were no SBIs. Most patients had mild (23.4%) or moderate (56.3%) adverse events. The majority of patients found the new infusion regimens to be better or somewhat better than their previous regimens and reported that switching to SCIG 16.5% was easy.
Conclusions
SCIG 16.5% (Cutaquig®), infusions are efficacious, safe, and well tolerated with reduced infusion time, fewer infusion sites, and reduced frequency. Further, the majority of patients found the new infusion regimens to be better or somewhat better than their previous regimens.
Prenatal diagnosis of cleft lip and palate: a study of clinical utility
Authors: Zhang Yan , Wang Degang , Wang Degang , Lu Jian , Yin Aihua , Tan Haowen , Lu Jiaqi , Ji Xueqi , Ding Hongke , Liu Qian , Tang Hui , Wang Limin , Huang Yanlin , Zhang Victor Wei , Wang Chunli , Liu Fenghua 
Published: March 2023

Abstract
Background
When a fetus was found has cleft lip palate (CL/P) by prenatal anatomical ultrasound assessment, it is difficult to determine the CL/P is isolated or companied with other animalities such as intellectual disability. We preformed comprehensive genetic test to support prenatal genetic counselling for CL/P fetus which is detected by ultrasound screening.
Results
105 unrelated fetuses with CL/P were enrolled. After excluding aneuploidy cases, SNP array and clinical exome sequencing (CES) were preformed simultaneously. All the fetuses were followed-up. Fetuses with CL/P were divided into two groups, cleft lip (CL)and cleft palate with or without cleft lip (CP/CLP). The detection rate was 12.4% (13/105) of the cases, in which SNP array contributed 3.8% (4/105) while CES added 8.6% yields. The positive rate of the CL group was lower than that of the CP/CLP group (0% (0/23) versus 15.9% (13/82), P = 0.067). CP/CLP with additional anomalies has higher positive rate than that of the apparently isolated CP/CLP (53.3% (8/15) versus 7.5% (5/67), P < 0.001). Furthermore, midline or bilateral CP/CLP had different yields in subgroups of CP/CLP. The rate of termination of pregnancy in positive group is much higher than that of the negative group (84.6% (11/13) versus 36.9% (31/84)).
Conclusions
Prenatal diagnosis with SNP array companied with CES was helpful for etiology analysis of fetuses with CL/P. Genetic etiology analysis was more valuable for CP/CLP than for CL. Moreover, SNP array companied with CES could change the clinical outcome for prenatal CL/P fetuses and reduce the residual risk for negative cases.
COVID-19 Resulted in Classrooms Without Walls: What can Pedagogical and Content Knowledge (PCK) Offer?
Authors: Bedeker Michelle 
Published: March 2023

Abstract
The pandemic resulted in countless tips about how technology can replace face-to-face instruction. This paper illustrates how pedagogical philosophies can impact online course decisions and how a PCK frame offers a gateway for thinking about epistemological access and social justice during Emergency Online Teaching (EOT). This research followed an intrinsic case study design including multiple data sets that were analyzed through inductive, deductive, and axial coding before generalizing patterns across students' reflective journals, FlipGrid recordings, daily tasks, and end-of-course feedback. The results showed that a collaborative online community of practice, self-directed learning, and integrated assessment provided student access and encouraged voice and engagement. Thus, post-COVID-19 PCK holds potential for instructional design and emancipatory online pedagogies in higher education.
Neuroprotective effects of ferrostatin and necrostatin against entorhinal amyloidopathy- induced electrophysiological alterations mediated by voltage-gated Ca 2+ channels in the dentate gyrus granular cells
Authors: Naderi Soudabeh , Motamedi Fereshteh , Pourbadie Hamid Gholami , Rafiei Shahrbanoo , Khodagholi Fariba , Naderi Nima , Janahmadi Mahyar 
Published: March 2023

Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is the main form of dementia. Abnormal deposition of amyloid-beta (Aβ) peptides in neurons and synapses cause neuronal loss and cognitive deficits. We have previously reported that ferroptosis and necroptosis were implicated in Aβ25−35 neurotoxicity, and their specific inhibitors had attenuating effects on cognitive impairment induced by Aβ25−35 neurotoxicity. Here, we aimed to examine the impact of ferroptosis and necroptosis inhibition following the Aβ25−35 neurotoxicity on the neuronal excitability of dentate gyrus (DG) and the possible involvement of voltage-gated Ca2+ channels in their effects. After inducing Aβ25−35 neurotoxicity, electrophysiological alterations in the intrinsic properties and excitability were recorded by the whole-cell patch-clamp under current-clamp condition. Voltage-clamp recordings were also performed to shed light on the involvement of calcium channel currents. Aβ25−35 neurotoxicity induced a considerable reduction in input resistance (Rin), accompanied by a profoundly decreased excitability and a reduction in the amplitude of voltage-gated calcium channel currents in the DG granule cells. However, three days of administration of either ferrostatin-1 (Fer-1), a ferroptosis inhibitor, or Necrostatin-1 (Nec-1), a necroptosis inhibitor, in the entorhinal cortex could almost preserve the normal excitability and the Ca2+ currents. In conclusion, these findings suggest that ferroptosis and necroptosis involvement in EC amyloidopathy could be a potential candidate to prevent the suppressive effect of Aβ on the Ca2+ channel current and neuronal function, which might take place in neurons during the early stages of AD.
Targeting Liver Metastases to Potentiate Immunotherapy In MS-stable colorectal cancer- A Scoping Review of Literature
Authors: Zlotnik Oran , Krzywon Lucyna , Kalil Jennifer , Bloom Jessica , Tubi Ikhtiyar Al , Lazaris Anthoula , Metrakos Peter 
Published: March 2023

Abstract
While Immunotherapy has revolutionized the treatment of several cancers such as lung cancer, melanoma, and other cancers, most colorectal cancer patients remain resistant. This resistance to immunotherapy may partially stem from the fact that colorectal cancer very commonly metastasizes to the liver. The liver is known to play an immunotolerant role in in other contexts such as organ transplantation, viral disease, and autoimmune disease. Recent studies reveal the mechanisms in which liver metastases restrict the efficacy of immunotherapy. This effect was shown to be reversable in colorectal cancer mice models, when colorectal liver metastases were irradiated. It is possible that targeting liver metastases with locoregional therapies such as ablation, resection or irradiation may reverse the immunosuppressive effect of liver microenvironment and potentiate immunotherapy systemically. During the past decade, several clinical trials are trying to extrapolate the results achieved in animal model to clinical trials by combining immunotherapy with locoregional therapy. In this scoping review, the current clinical and translational literature was surveyed, to determine whether there is evidence to support the validity of this concept in human patients. If indeed immunotherapy can be potentiated for MS- Stable colorectal cancer utilizing locoregional interventions, a wide array of innovative protocols can be utilized to help cancer patients who have no other available treatment options and thus revolutionize the treatment of cancer patients with liver metastases.
Evaluation of an app-based food frequency questionnaire: Comparison with 24-hour dietary recalls among women in two rural areas of Kenya
Authors: Kishino Madoka , Hida Azumi , Kariuki Lucy , Maundu Patrick , Irie Kenji , Morimoto Yasuyuki 
Published: March 2023

Abstract
Background
An initiative aimed at improving nutrition intervention programs by providing food consumption data for better decision-making and promoting local foods has led to the development of an application-based food assessment tool called the Agrobiodiversity and Diet Diagnosis for Interventions Toolkit (ADD-IT). A new food frequency questionnaire (FFQ) was developed based on our previous study, which included 49 dishes and food items and asked about their frequency of consumption and portion size with photos. This study aimed to evaluate the validity of the FFQ.
Methods
We compared the estimated intake of energy, macro- and micronutrients, and food groups collected with the ADD-IT-based FFQ for one month with the estimated intake by means of nonconsecutive two-day 24-hour dietary recalls (24hDRs) of food consumption among women aged 19–70 years (mean = 33.7) in two rural areas—Kitui and Vihiga—in Kenya (N = 179). Spearman's rank correlation coefficients, cross-classification agreement, and Bland-Altman plots were used to assess the validity of the FFQ against the 24hDRs. Food consumption patterns for different communities were characterized by the FFQ and 24hDRs using the Mann-Whitney U test to ensure consistency in the results.
Results
The correlation coefficients ranged from low (-0.062) to moderate (0.479) between the FFQ and 24hDR. On median, approximately 71% of participants were correctly classified into the same or adjacent quartile, while 9% were misclassified by estimated nutrient intake from the FFQ. Bland-Altman plots ensured that there was no significant systematic bias for energy and macronutrients. The FFQ identified each community’s characteristic food consumption patterns as almost the same as those of the 24hDRs.
Conclusions
The newly developed app-based FFQ can be used to rank or classify individuals within each population according to their dietary intake and estimate the characteristics of their food intake patterns. However, selective reporting errors exist for specific foods. Several suggestions have been made to reduce such errors and improve the validation.
Anxiety and depression during the COVID-19 pandemic in healthcare students
Authors: Luz Adriana Gomes , Gazzoli Emily , Juliato Cássia Raquel Teatin , Tanaka Erika Zambrano Tanaka , Angelini Carina Fernanda Robles , Mazzola Priscila Gava , Surita Fernanda Garanhani de Castro 
Published: March 2023

Abstract
Background: The coronavirus (COVID-19) pandemic corroborated a state of mental stress worldwide, in health students like health professionals, so it is essential to analyze the emotional stability of these students.
OBJECTIVE: To evaluate depression and anxiety among undergraduate healthcare students using validated scales, in addition to knowing their reactions and perceptions about the implementation of emergency remote education (ERS) in this period of isolation due to the COVID-19 pandemic.
METHODS: We invited by institutional e-mail, healthcare students regularly enrolled at the University of Campinas. After agreement and consent, a google form link was sent to access the data collection form.
RESULTS: We sent 1204 invitations and 270 (22.4%) students agreed to participate (medicine 17.4%, nursing 19.3%, pharmacy 36.3%, and phonoaudiology 27%). Most participants were female (83%), up to 22 years of age (63%), white (69%), and between the first and third years of the course (64. 5%). Regarding remote education, 51.1% of participants reported having some degree of difficulty to follow up. Regarding the perception of social relationships, 37.8% considered themselves to be compromised, and 72.2% reported not feeling able to act in the COVID pandemic. Regarding mental health, 74% had high levels of anxiety, and 37% had moderate or severe depression.
CONCLUSION: Healthcare students had high levels of severe anxiety and moderate/severe depression. Dissatisfaction with remote education contributed to the increase in depression rates in all courses. Healthcare students’ needs future strategies for mental health during pandemic conditions.
Primary care provider perspectives on the role of community pharmacy in colorectal cancer screening: A qualitative study
Authors: Brenner Alison T , Rohweder Catherine L. , Wangen Mary , Atkins Dana L. , Ceballos Rachel M. , Correa Sara , Ferrari Renée M. , Issaka Rachel B. , Ittes Annika , Odebunmi Olufeyisayo , Reuland Daniel S. , Waters Austin R. , Wheeler Stephanie B. , Shah Parth D. 
Published: March 2023

Abstract
Background
The United States Preventive Services Task Force (USPSTF) lists 32 grade A or B recommended preventive services for non-pregnant United States (US) adults, including colorectal cancer screening (CRC). Little guidance is given on how to implement these services with consistency and fidelity in primary care. Given limited patient visit time and competing demands, primary care providers (PCPs) tend to prioritize a small subset of these recommendations. Completion rates of some of these services, including CRC screening, are suboptimal. Expanding delivery of preventive services to other healthcare providers, where possible, can improve access and uptake, particularly in medically underserved areas or populations. Fecal immunochemical testing (FIT) (at-home, stool-based testing) for CRC screening can be distributed and resulted without PCP involvement. Pharmacists have long delivered preventive services (e.g., influenza vaccination) and may be a good option for expanding CRC screening delivery using FIT, but it is not clear how PCPs would perceive this expansion.
Methods
We used semi-structured interviews with PCPs in North Carolina and Washington state to assess perceptions and recommendations for a potential pharmacy-based FIT distribution program (PharmFIT™). Transcripts were coded and analyzed using a hybrid inductive-deductive content analysis guided by the Consolidated Framework for Implementation Research (CFIR) to elucidate potential multi-level facilitators of and barriers to implementation of PharmFIT™.
Results
We completed 30 interviews with PCPs in North Carolina (N = 12) and Washington (N = 18). PCPs in both states were largely accepting of PharmFIT™, with several important considerations. First, PCPs felt that pharmacists should receive appropriate training for identifying patients eligible and due for FIT screening. Second, a clear understanding of responsibility for tracking tests, communication, and, particularly, follow-up of positive test results should be established and followed. Finally, clear electronic workflows should be established for relay of test result information between the pharmacy and the primary care clinic.
Conclusion
If the conditions are met regarding pharmacist training, follow-up for positive FITs, and transfer of documentation, PCPs are likely to support PharmFIT™ as a way for their patients to obtain and complete CRC screening using FIT.
Decision tree predictive model for dimensional control of side flange bearing housings
Authors: Soares Rafael Gonçalves , Dalpra Gabriella , Silva Alisson 
Published: March 2023

Abstract
This paper introduces a prediction model based on machine learning techniques for dimensional control in the manufacturing process of side flange bearing housings, according to the technical standard DIN 31693. The process is implemented in a journal-bearing manufacturing industry positioned among the three brands with the highest participation in the international market in 2023. The manufacturing process consists of rigid machining processes composed of a universal horizontal machining center and dimensional control composed of a coordinate measuring machine. After machining, the piece is measured, and its dimensional report is generated. Qualified professionals use deviations obtained from this report to support the decision-making. The method used is based on the holistic monitoring of the surface geometry of the machined piece. The approach used to compensate for dimensional deviations is based on monitoring and modeling the total deviation. In this context, the effects of all sources of systematic errors are compensated regardless of their origin. The heuristic is used for the steps that make up the decision-making process. The way to implement the predictive model in the production line is based on the interaction between human and machine experience. This paper proposes using the regression decision trees for defining the displacement parameters of the machining center axes from the dimensional results of housings obtained in the coordinate measuring machine. The model is validated if the mean absolute error is less than or equal to 0.003mm. A comparison between an assembled model is performed to verify the performance between different predictive models.
Emerging Electric or Magnetic Parts of Weyl Tensor on PNDP- Manifold
Authors: Sati Monika , Petwal K. C. , Pigazzini Alexander , Ozel Cenap , Bisht Manoj Singh , Linker Patrick 
Published: March 2023

Abstract
In the present paper, we study the PNDP- manifold, which has shown to be effective in applications, particularly in the field of general relativity, by introducing a new topological approach to the emergent electric or magnetic parts associated to the Weyl tensor. The working hypothesis in this study is that the electric or magnetic parts of the Weyl tensor are the dimensions of the PNDP - manifold and the interaction that emerges as ”virtual” pointlike manifolds and as a manifold with positive/ negative dimensions results in the generation of the purely electric or purely magnetic parts of the Weyl tensor. The PNDP metric for the electric or magnetic parts of the Weyl tensor is also derived.
The generalized Lorentz transformations on the PNDP manifold are introduced. These can give rise to novel forms of gauge theories if we consider local Lorentz transformations. Also we briefly show that principal fiber bundles with PNDP manifolds as base manifolds can be constructed.
Mathematics Subject classifiction (2010): 53C25; 83C99; 53A45; 53B50
Interface Engineering Induced NiFe/Ni-Mo-S@CC Heterostructure with excellent OER and HER performance
Authors: Gong Zhangquan , Cheng Wentao , Fang Zheng , Li Na , Qin Yanmin , Wang Xing , Bao Haifeng 
Published: March 2023

Abstract
The development of high-efficiency, low-cost and stable noble-metal-free electrocatalysts for water splitting is essential for the sustainable production of hydrogen. Herein, hierarchical Ni-Mo-S nanosheet decorated by NiFe alloy nanoparticle grown on carbon cloth (NiFe/Ni-Mo-S@CC) is designed as bifunctional electrocatalyst for overall water splitting. Benefiting from the strong synergistic effect between NiFe alloy and Ni-Mo-S, the NiFe/Ni-Mo-S@CC heterostructure exhibits superior electrocatalytic activity with extremely low overpotentials of 161 mV for oxygen evolution reaction (OER) at 10 mA cm-2 and 72 mV for hydrogen evolution reaction (HER) at 10 mA cm-2, respectively. In addition, the alkaline electrolyzer with NiFe/Ni-Mo-S@CC as both cathode and anode yield a low cell voltage of only 1.49 V to reach the current density of 10 mA cm-2. The formation of NiFe/Ni-Mo-S@CC heterostructure provides an efficient way to develop catalysts for water splitting.
COVID-19 Infection and Dementia: Analyses of time-varying risk, subtypes, and subpopulations from the UK Biobank
Authors: Cao Yaying , Feng Chengwu , Chen Jing , Liu Yunman , Sheng Aili , Li Shuai , Hu Yonghua , Yuan Changzheng , Xie Junqing , Zong Geng 
Published: March 2023

Abstract
Background
Although COVID-19 patients were suggested to experience worse cognitive outcomes, there is a paucity of evidence on time-varying risk of dementia, especially the subtypes, as well as among critical subpopulations.
Methods
Out of over 50000 individuals from general population in the UK Biobank, SARS-COV-2 infected patients between March 1, 2020, and July 31, 2021 and maximally 5:1 propensity score matched contemporary non-infected individuals were selected, with baseline dementia excluded. Matching was done on demographic characteristics, lifestyle, and comorbidities. Dementia was captured according to primary care, inpatient records, and death registry, with the follow-up ending at the earliest of outcome occurrence, death, or August 31, 2021. Associations were evaluated using time-varying hazard ratios (HRs) and odds ratios (ORs).
Results
With a mean age of 64.5 years for 18032 COVID-19 patients and 83,008 controls, participants were followed for a median of 247 (IQR: 204–305) days and 255 dementia cases occurred, including 90 Alzheimer’s disease (AD) cases and 42 vascular dementia (VaD) cases. Compared with matched controls, dementia risk declined drastically after COVID-19 infection and sustained for all-cause dementia, VaD, and other dementia. During the acute phase (first 30 days), COVID-19 infection was associated with increased risks of dementia, with HRs (95% CIs) being 12.77 (6.77, 24.08) for all-cause dementia, 9.21 (2.77, 30.59) for AD, 5.53 (1.69, 18.11) for VaD, and 25.35 (8.74, 73.56) for other dementia. Among those not hospitalized within 30 days of enrollment, elevated dementia risk remained for all-cause dementia, VaD, and other dementia, with ORs being 1.82, 4.55, and 1.64, respectively. Among most of the subpopulations classified by demographic characteristics, APOE genotype, and comorbidities (except for those with chronic obstructive pulmonary diseases at enrollment), COVID-19 infection was associated with an elevated all-cause dementia risk and no modification effect was detected.
Conclusions
Declined yet sustained elevated dementia risk since COVID-19 infection was found and vascular risk factors may need extra attention during the long-term follow-up. Increased dementia risk from COVID-19 infection also applied for the non-hospitalized during the acute phase and most subpopulations. The potential dementia risk associated with Omicron and newer variants warrants further evaluation.