bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and crystal structure of the copper (II) carboxylate with 2,2-bipyridine, [Cu(4-mba)2(bipy)(H2O)]
Authors: Kanmazalp Sibel Demir , Qadir Adnan , Dege Necmi 
Published: March 2023

The new Cu(II) carboxylate complex, aqua(2,2'-bipyridine-κ2N,N')bis(4-methylbenzoato-κO)copper(II) [Cu(4-mba)2(bipy)(H2O)] (4-mba: 4-methylbenzoate, bipy: 2,2'-bipyridine) was synthesized, and the molecular structure of the complex was characterized by the single crystal X-ray diffraction technique. The X-ray diffraction analysis indicated that the asymmetric unit comprises an independent molecule. Crystal data for [Cu(4-meb)2(2,2-bipy)(H2O)]: Triclinic, space group P-1 (no. 2), a = 7.0452(13) Å, b = 11.260(2) Å, c = 16.635(3) Å, α = 103.543(7)°, β = 91.002(7)°, γ = 104.106(6)°, V = 1240.4(4) Å3, Z = 2, T = 296 K, μ(MoKα) = 0.918 mm-1, Dcalc = 1.360 g/cm3, 51364 reflections measured (5.054° ≤ 2Θ ≤ 57.38°), 6258 unique (Rint = 0.0398, Rsigma = 0.0284) which were used in all calculations. The final R1 was 0.0392 (I > 2σ(I)) and wR2 was 0.1021 (all data). The Cu(II) ion was found to be coordinated with two nitrogen atoms of the 2,2'-bipyridine ligand, two oxygen atoms of the 4-methyl benzoate molecule, and one oxygen atom of the aqua ligand. In the three-dimensional supramolecular architecture, molecules are connected through pairs of O-H···O and C-H···O intermolecular interactions, consisting of chains. The molecule also demonstrates Cg···Cg intermolecular interactions between six-membered rings of 2,2'-bipyridine.
PENURUNAN KADAR BESI (Fe) DENGAN SISTEM AERASI DAN FILTRASI PADA AIR SUMUR GALI
Authors: Amiliza Miarti  
Published: March 2023

Pengadaan air bersih di Indonesia khususnya untuk skala yang besar masih terpusat didaerah perkotaan, dan dikelola oleh Perusahaan Air Minum (PAM) kota yang bersangkutan. Namun demikian secara nasional jumlahnya masih relatif kecil dan dapat dikatakan belum mencukupi.
Penelitian ini bertujuan untuk mengetahui penurunan kadar besi (Fe) dengan sistem aerasi dan filtrasi pada air sumur gali. Penelitian untuk mengetahui kadar besi dengan sistem aerasi dan filtrasi pada air sumur gali dengan desain pre-pos Test atau melakukan uji pada air baku dan air hasil pengolahan. Dalam proses penelitian akan dilakukan replikasi atau pengulangan proses pengolahan hingga media filter mencapai titik jenuh.
Penurunan kadar besi (Fe) setelah perlakuan Aerasi dapat menurunkan kadar besi (Fe) hingga mencapai persentase Penurunan sebesar 66,7%. Dan hasil yang diperoleh telah sesuai persyaratan yang telah di tentukan sesuai Permenkes RI No. 416/MENKES/PER/IX/1990, yaitu 1.0 mg/l.
Phenomenology Causes of the Low Application of Community-Based Total in Coastal Area, Konawe Island Regency
Authors: Anil Musmina Nila , Azizi Jayadipraja Erwin , Umi Nurlila Ratna 
Published: March 2023

Introduction: Community-based total sanitation is a strategy for involving the community in sanitation programs that are carried out to change sustainable hygienic and sanitary behavior. The coastal area of Konawe Kepulauan Regency ranks the 2nd lowest in the implementation of Community-based total sanitation. The purpose of this study was to determine the cause of the low community-based total sanitation Stop Open Defecation and Management of Household Waste in the Coastal Area of Konawe Islands Regency.
Method: This type of research uses qualitative research, a phenomenological approach. Informants consist of key informants as many as 5 people, regular informants 7 people, and people residing in the area of Langara and Lansilowo Health Center. Snowball sampling technique and data analysis using data reduction, data display, and data conclusion techniques.
Result: The results showed thatthere are still many people who have not implemented stop defecation due to a lack of knowledge, housing conditions in coastal areas, lack of latrines, habituation, and the economy. The community does not dispose of waste in its place due to several factors, namely the absence of a temporary disposal site and final disposal site.
Conclusion: The phenomenon that causes people not to apply community-based total sanitation in the Coastal Area of Konawe Islands Regency is due to a lack of community knowledge, economic factors, lack of facilities or infrastructure, and also a habitual factor so that they have not implemented Community-based total sanitation on the coast of Konawe Islands Regency
MỘT SỐ YẾU TỐ TẾ BÀO TRONG TIÊN LƯỢNG Ở BỆNH NHÂN ĐA U TỦY XƯƠNG CÓ SUY THẬN ĐƯỢC ĐIỀU TRỊ TẠI BỆNH VIỆN BẠCH MAI
Authors: Phạm Phương Thảo , Vũ Minh Phương , Dương Hải Yến 
Published: March 2023

Mục tiêu: 1. Mô tả một số yếu tố tế bào ở bệnh nhân đa u tủy xương (ĐUTX) có suy thận. 2. Phân tích mối liên quan giữa yếu tố tế bào với kết quả điều trị nhóm bệnh nhân nghiên cứu. Đối tượng và phương pháp nghiên cứu: thiết kế nghiên cứu: thuần tập hồi cứu. 51 bệnh nhân đa u tủy xương có suy thận tại Trung tâm Huyết học Truyền máu bệnh viện Bạch Mai từ năm 2019 đến năm 2022 được phân tích các chỉ số trước điều trị bao gồm: NLR (tỷ lệ bạch cầu trung tính/ bạch cầu lympho), LMR (tỷ lệ bạch cầu lympho/ bạch cầu mono), NMLR (tỷ lệ bạch cầu trung tính + mono/ bạch cầu lympho), HGB (nồng độ hemoglobin), SLTC (số lượng tiểu cầu), và đánh giá mức độ lui bệnh, OS (thời gian sống toàn bộ).Kết quả nghiên cứu: Tuổi trung bình của nhóm nghiên cứu là 58,5 tuổi, nam giới chiếm 64,7%, thể bệnh gặp nhiều nhất là ĐUTX chuỗi nhẹ (49,1%). Chỉ số NLR ≥ 2, LMR < 3,6, HGB <100 g/l, SLTC <150 G/l, là những yếu tố tiên lượng xấu có liên quan đến giảm thời gian sống toàn bộ (OS), và tỷ lệ lui bệnh 1 phần rất tốt (MPRT) trở lên. Kết luận: NLR, NMLR tăng cao, LMR, SLTC, HGB giảm thấp là yếu tố tiên lượng xấu đối với OS và đáp ứng điều trị của bệnh nhân đa u tủy xương có suy thận.
Entre o texto e a vida: a formação continuada de professores da educação infantil na região do alto Sertão da Paraíba
Authors: De Oliveira Hellyegenes , Pandini-Simiano Luciane 
Published: March 2023

O texto tem por foco analisar as iniciativas e estratégias na formação continuada de professores da Educação Infantil. A pesquisa, desenvolvida em uma perspectiva quanti-qualitativa, foi realizada no âmbito do Mestrado em Educação. Teve como sujeitos treze secretários municipais de Educação que atuam nos municípios da região de Sousa, no Sertão da Paraíba. Como instrumento de pesquisa foi utilizado um questionário contendo perguntas fechadas e uma aberta. A análise do material produzido foi realizada por meio da técnica de análise de conteúdo de Bardin. A partir do diálogo com a legislação educacional brasileira e entre diferentes autores, como Campos, Kramer, Tardif e Lessard, e Dourado, o resultado permitiu observar que, embora todos os municípios relatem desenvolver formação continuada com os professores, ainda se evidenciam lacunas quanto à especificidade da formação na área da Educação Infantil. Do texto à vida, as políticas da Educação Infantil parecem imprimir a garantia do direito à formação continuada de professores nessa etapa da educação básica, contudo seus efeitos no contexto da prática ainda permanecem invisíveis, despercebidos. A organização, a forma e o conteúdo das formações remetem à necessidade de (re)pensar um percurso formativo que possibilite aos professores dialogar, refletir, questionar, ampliar sua leitura da educação e cuidado na primeira infância e de mundo.
MODEL PEMBELAJARAN QUANTUM LEARNING DENGAN MEDIA SQUARE BOARD TERHADAP HASIL BELAJAR SISWA PADA MATERI SEGIEMPAT
Authors: Octaviani Rosalia , Suprapti Endang , Hidayatullah Achmad 
Published: March 2023

This research aims to determine the effect of Square Board Media with Quantum Learning model on learning outcomes, student and teacher activities and student responses in class VII-D students of Muhammadiyah 2 Junior High School Surabaya. This research is a type of quantitative research with the True Experimental method. The design used in this study is Pretest-Posttest Control Group Design. Samples taken were 52 students consisting of 26 experimental class students and 26 control class students. The results showed that the average final test score in the experimental class was better than the average test final score in the class control; (2) The most dominant student activity occurs is the activity of students "discussing with groups and actively participating in activities" with a percentage of 33%; (3) Teacher's activity in managing learning gets an average score of 3.5 with very good criteria; and (4) Student responses to learning showed that ≥ 90 students respond positively. Thus, it can be concluded that mathematics learning with Square Board Media has a positive and significant effect on class VII-D students of Muhammadiyah 2 Junior High School Surabaya
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ANALISIS KEMAMPUAN REPRESENTASI MATEMATIS SISWA KELAS VII SMP NEGERI 16 KUPANG
Authors: Lopi Ridno , Yusuf St Muthmainnah , Ralmugiz Uke 
Published: March 2023

The purpose of this study is to analyze the mathematical representation capabilities of junior high school students. This research has been conducted at SMP Negeri 16 Kupang School Year 2019/2020. The method used in the study was a descriptive analysis method, which involved 76 students as samples. The student's mathematical representation ability test instrument used as many as 3 questions in the form of descriptions. The results revealed that students' mathematical representation skills in Comparative materials had an average score of 72.51. Students' mathematical representation ability on symbol representation indicators with an average of 85.33 is higher than the verbal representation and image representation indicators; image representation indicator with a score of 60 is still below average; and verbal representation indicators have an average of 72.66. There are several factors that affect the level of ability of mathematical representation of students, including students still find it difficult to convert mathematics symbols into images, turn math problems into mathematical symbols or models and convey mathematical ideas using their own language and words. The ability of students to solve math problems using symbol and verbal representation is quite satisfactory while students use image representation is not maximal.
PERBANDINGAN MODEL PEMBELAJARAN OSBORN DAN MODEL PEMBELAJARAN MATEMATIKA INTERAKTIF BERBASIS KOMPUTER TERHADAP HASIL BELAJAR SISWA KELAS X TKJ SMK NEGERI 1 SINJAI
Authors: Musdalifah  , P Sudirman , Nurjannah  
Published: March 2023

This study aims to compare student learning outcomes in mathematics with the use of Osborn and computer-based interactive mathematics learning model in class X TKJ SMKN 1 Sinjai. This type of research is an experimental research with a quantitative approach with a pretest postest control group design research design. The population in this study were students of class X TKJ SMK Negeri 1 Sinjai. While the sample used is simple random sampling. Based on the descriptive analysis of student learning outcomes in class X TKJ 1 after the application of the Osborn learning model as a control class, the average pre-test of the Osborn learning model was 76.80 and the post-test was 79.25 which was greater than the KKM (65). Based on the inferential analysis, the results of this study indicate that the Sig. (2-tailed) in the paired sample t-test of 0.000 where the value is less than 0.05. Thus, it can be concluded that there are differences in learning outcomes between Osborn and the computer-based interactive learning model for the tenth graders of TKJ SMK Negeri 1 Sinjai.
Outcome of Coronary Artery Bypass Graft Surgery with Low Preoperative Ejection Fraction: A Cross-sectional study
Authors: Bhuyan Amirul Islam , Kawsar Syeda Masuma 
Published: March 2023

Background: Coronary artery bypass graft (CABG) surgery has been proven in several trials to have excellent outcomes in patients with coronary artery disease who have reasonably preserved cardiac function. Nonetheless, determining the value of coronary artery bypass grafting (CABG) in patients with low left ventricular ejection faction (shown as left ventricular ejection fraction 40B) has been challenging due to worries about increased operating mortality and decreased long-term survival.
Objective: Our main goal is to evaluate the Outcome of Coronary Artery Bypass Graft Surgery with Low Preoperative Ejection Fraction.
Methods: This cross-sectional study carried out at tertiary hospital from June 2021 to June 2022. Where 100 patients who underwent coronary artery bypass graft (CABG) surgery in the Department of Cardiac Surgery were included in the study. The patients were divided into 2 groups as follows: Group—I, EF < 40% (n = 50) and Group-ll EF>40% (n = 50).
Results: During the study, where 55% were belong to 50-60 years age group and majority were male. In both group majority had diabetes and hypertension. All of the co—morbidities/risk factors were almost equally distributed between groups (p > 0,05). Except incidence of bleeding, which was significantly higher in Croup—I than that in Group—II (p = 0.01 0). In addition to that, in group 1 Heart failure seen in 1.5% cases followed by 2.3% had pneumonia, prolonged ventilation seen in 13.5%. Where as in group 2 Heart failure seen in 0.5% cases followed by 1.8% had pneumonia, prolonged ventilation seen in 11%.
Conclusion: Lastly, the current study's large sample size suggests that CABG may be performed on patients with low EF <40% with outcomes (in terms of morbidity and death) that are equivalent to those of patients with EF > 40.
Association Between Daily Alcohol Intake and Risk of All-Cause Mortality
Authors: Zhao Jinhui , Stockwell Tim , Naimi Tim , Churchill Sam , Clay James , Sherk Adam 
Published: March 2023

ImportanceA previous meta-analysis of the association between alcohol use and all-cause mortality found no statistically significant reductions in mortality risk at low levels of consumption compared with lifetime nondrinkers. However, the risk estimates may have been affected by the number and quality of studies then available, especially those for women and younger cohorts.ObjectiveTo investigate the association between alcohol use and all-cause mortality, and how sources of bias may change results.Data SourcesA systematic search of PubMed and Web of Science was performed to identify studies published between January 1980 and July 2021.Study SelectionCohort studies were identified by systematic review to facilitate comparisons of studies with and without some degree of controls for biases affecting distinctions between abstainers and drinkers. The review identified 107 studies of alcohol use and all-cause mortality published from 1980 to July 2021.Data Extraction and SynthesisMixed linear regression models were used to model relative risks, first pooled for all studies and then stratified by cohort median age (&amp;lt;56 vs ≥56 years) and sex (male vs female). Data were analyzed from September 2021 to August 2022.Main Outcomes and MeasuresRelative risk estimates for the association between mean daily alcohol intake and all-cause mortality.ResultsThere were 724 risk estimates of all-cause mortality due to alcohol intake from the 107 cohort studies (4 838 825 participants and 425 564 deaths available) for the analysis. In models adjusting for potential confounding effects of sampling variation, former drinker bias, and other prespecified study-level quality criteria, the meta-analysis of all 107 included studies found no significantly reduced risk of all-cause mortality among occasional (&amp;gt;0 to &amp;lt;1.3 g of ethanol per day; relative risk [RR], 0.96; 95% CI, 0.86-1.06; P = .41) or low-volume drinkers (1.3-24.0 g per day; RR, 0.93; P = .07) compared with lifetime nondrinkers. In the fully adjusted model, there was a nonsignificantly increased risk of all-cause mortality among drinkers who drank 25 to 44 g per day (RR, 1.05; P = .28) and significantly increased risk for drinkers who drank 45 to 64 and 65 or more grams per day (RR, 1.19 and 1.35; P &amp;lt; .001). There were significantly larger risks of mortality among female drinkers compared with female lifetime nondrinkers (RR, 1.22; P = .03).Conclusions and RelevanceIn this updated systematic review and meta-analysis, daily low or moderate alcohol intake was not significantly associated with all-cause mortality risk, while increased risk was evident at higher consumption levels, starting at lower levels for women than men.
Mesenchymal Stem Cell Aggregation‐Released Extracellular Vesicles Induce CD31+EMCN+ Vessels in Skin Regeneration and Improve Diabetic Wound Healing
Authors: Liu Lu , Zheng Chen‐Xi , Zhao Na , Zhu Ting , Hu Cheng‐Biao , Zhang Nan , Chen Ji , Zhang Kai‐Chao , Zhang Sha , Liu Jie‐Xi , Zhang Kai , Jing Huan , Sui Bing‐Dong , Jin Yan , Jin Fang 
Published: March 2023

AbstractThe blood vessel system is essential for skin homeostasis and regeneration. While the heterogeneity of vascular endothelial cells has been emergingly revealed, whether a regeneration‐relevant vessel subtype exists in skin remains unknown. Herein, a specialized vasculature in skin featured by simultaneous CD31 and EMCN expression contributing to the regeneration process is identified, the decline of which functionally underlies the impaired angiogenesis of diabetic nonhealing wounds. Moreover, enlightened by the developmental process that mesenchymal condensation induces angiogenesis, it is demonstrated that mesenchymal stem/stromal cell aggregates (CAs) provide an efficacious therapy to enhance regrowth of CD31+EMCN+ vessels in diabetic wounds, which is surprisingly suppressed by pharmacological inhibition of extracellular vesicle (EV) release. It is further shown that CAs promote secretion of angiogenic protein‐enriched EVs by proteomic analysis, which directly exert high efficacy in boosting CD31+EMCN+ vessels and treating nonhealing diabetic wounds. These results add to the current knowledge on skin vasculature and help establish feasible strategies to benefit wound healing under diabetic condition.
MY‐1‐Loaded Nano‐Hydroxyapatite Accelerated Bone Regeneration by Increasing Type III Collagen Deposition in Early‐Stage ECM via a Hsp47‐Dependent Mechanism
Authors: Yanli Zhang , Jiayao Mo , Chunqing Zheng , Yuting Zeng , Zhiyan Zhou , Yulin Zhang , Minghan Li , Longquan Shao , Dehong Yang , Wenjuan Yan 
Published: March 2023

AbstractThe extracellular matrix (ECM) plays a crucial part in regulating stem cell function through its distinctive mechanical and chemical effect. Therefore, it is worth studying how to activate the driving force of osteoblast cells by dynamic changing of ECM and accelerate the bone regeneration. In this research, a novel peptide MY‐1 is designed and synthesized. To achieve its sustained releasing, the nano‐hydroxyapatite (nHA) is chosen as the carrier of MY‐1 by mixed adsorption. The results reveal that the sustainable releasing of MY‐1 regulates the synthesis and secretion of ECM from rat bone marrow mesenchymal stem cells (rBMSCs), which promotes the cell migration and osteogenic differentiation in the early stage of bone regeneration. Further analyses demonstrate that MY‐1 increases the expression and nuclear translocation of β‐catenin, and then upregulates the level of heat shock protein 47 (Hsp47), thereby accelerating the synthesis and secretion of type III collagen (Col III) at the early stage. Finally, the promoted rapid transformation of Col III to Col I at late stage benefits the bone regeneration. Hence, this study can provide a theoretical basis for the local application of MY‐1 in bone regeneration.
Multiple Resonance Organoboron OLED Emitters with High Efficiency and High Color Purity via Managing Long‐ and Short‐Range Charge‐Transfer Excitations
Authors: Huang Feng , Fan Xiao‐Chun , Cheng Ying‐Chun , Xie Yue , Luo Shulin , Zhang Tao , Wu Hao , Xiong Xin , Yu Jia , Zhang Dan‐Dan , Chen Xian‐Kai , Wang Kai , Zhang Xiao‐Hong 
Published: March 2023

AbstractMultiple resonance (MR) type thermally activated delayed fluorescence (TADF) emitters are very promising in the high‐resolution and high‐efficiency displays, due to their narrow and highly efficient optical emissions. Early MR‐TADF cores that show only short‐range charge‐transfer (CT) electronic excitations hardly afford ideal performances (e.g., show low efficiencies) in organic light‐emitting diodes (OLEDs). This work thus designs and synthesizes two MR‐TADF emitters (TCzBN‐BP and TCzBN‐FP), where the same MR core TCzBN is chemically modified by the acceptor fragments benzophenone/9‐fluorenone (BP/FP) to incorporate long‐range CT excitations in the two molecules. OLEDs exploiting TCzBN‐BP as emitter, in which short‐range CT excitation is dominant in the first singlet (S1) excited state, achieve a maximum external quantum efficiency (EQE) of 35.6% and a narrow emission bandwidth of 35 nm. In contrast, OLEDs exploiting TCzBN‐FP with an overloaded long‐range CT excitation in the S1 state exhibit a maximum EQE of 27.2% and a broadened emission bandwidth of 56 nm. This work not only shows the importance of careful management of long‐ and short‐range CT excitations, but also provides a new insight into the structure–property relationship in the MR‐TADF emitters, which thus promotes the design of more novel MR‐TADF emitters with high efficiencies and high color purity.
Programming of Multicellular Patterning with Mechano‐Chemically Microstructured Cell Niches
Authors: Newman Peter L. H. , Yip Queenie , Osteil Pierre , Anderson Tim A. , Sun Jane Q. J. , Kempe Daryan , Biro Maté , Shin Jae‐Won , Tam Patrick P. L. , Zreiqat Hala 
Published: March 2023

AbstractMulticellular patterning of stem‐cell‐derived tissue models is commonly achieved via self‐organizing activities triggered by exogenous morphogenetic stimuli. However, such tissue models are prone to stochastic behavior, limiting the reproducibility of cellular composition and forming non‐physiological architectures. To enhance multicellular patterning in stem cell‐derived tissues, a method for creating complex tissue microenvironments endowed with programmable multimodal mechano‐chemical cues, including conjugated peptides, proteins, morphogens, and Young's moduli defined over a range of stiffnesses is developed. The ability of these cues to spatially guide tissue patterning processes, including mechanosensing and the biochemically driven differentiation of selected cell types, is demonstrated. By rationally designing niches, the authors engineered a bone‐fat assembly from stromal mesenchyme cells and regionalized germ layer tissues from pluripotent stem cells. Through defined niche‐material interactions, mechano‐chemically microstructured niches enable the spatial programming of tissue patterning processes. Mechano‐chemically microstructured cell niches thereby offer an entry point for enhancing the organization and composition of engineered tissues, potentiating structures that better recapitulate their native counterparts.