bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediagnostic serum glyceraldehyde‐derived advanced glycation end products and mortality among colorectal cancer patients
Authors: Mao Ziling , Baker Jacqueline Roshelli , Takeuchi Masayoshi , Hyogo Hideyuki , Tjønneland Anne , Eriksen Anne Kirstine , Severi Gianluca , Rothwell Joseph , Laouali Nasser , Katzke Verena , Kaaks Rudolf , Schulze Matthias B. , Palli Domenico , Sieri Sabina , de Magistris Maria Santucci , Tumino Rosario , Sacerdote Carlotta , Derksen Jeroen W. G. , Gram Inger T. , Skeie Guri , Sandanger Torkjel M. , Quirós Jose Ramón , Crous‐Bou Marta , Sánchez Maria‐Jose , Amiano Pilar , Colorado‐Yohar Sandra M. , Guevara Marcela , Harlid Sophia , Johansson Ingegerd , Perez‐Cornago Aurora , Freisling Heinz , Gunter Marc , Weiderpass Elisabete , Heath Alicia K. , Aglago Elom , Jenab Mazda , Fedirko Veronika 
Published: January 2023

AbstractGlyceraldehyde‐derived advanced glycation end products (glycer‐AGEs) could contribute to colorectal cancer development and progression due to their pro‐oxidative and pro‐inflammatory properties. However, the association of glycer‐AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer‐AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer‐AGEs concentrations with CRC‐specific and all‐cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow‐up, 529 participants died (409 from CRC). Glycer‐AGEs were statistically significantly positively associated with CRC‐specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04‐2.25, Ptrend = .002) and all‐cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16‐2.26, Ptrend < .001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer‐AGEs and CRC‐specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74‐1.42; HRdistal colon = 1.51, 95% CI: 1.20‐1.91; Peffect modification = .02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer‐AGEs category relative to lowest BMI and glycer‐AGEs category for both CRC‐specific (HR = 1.78, 95% CI: 1.02‐3.01) and all‐cause mortality (HR = 2.15, 95% CI: 1.33‐3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer‐AGEs are positively associated with CRC‐specific and all‐cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.
Homogeneous Pt nanostructures surface functionalized with phenylboronic acid phosphonic acid derivatives as potential biochemical nanosensors and drugs: SERS and TERS studies
Authors: Proniewicz Edyta , Gralec Barbara , Ozaki Yukihiro 
Published: January 2023

AbstractHere, surface‐enhanced Raman scattering (SERS) and tip‐enhanced Raman scattering (TERS) were used to characterize the selective adsorption of N‐substituted 4‐[(NH‐R)(phosphono)‐S‐methyl]phenylboronic acids on the surface of platinum nanoparticles (PtNPs) from an aqueous solution and from air. The nature of the interaction of the studied compounds with the PtNPs/H2O and PtNPs/air interfaces was discussed and compared. For this purpose, 4‐[(N‐anilino)(phosphono)‐S‐methyl]phenylboronic acid (1‐PBA‐PA) and its two analogs (2‐PBA‐PA and bis{1‐PBA‐PA}) as well as the PtNPs were synthesized in surfactant/ion‐free solution via a synthetic route that allows control of the size and morphology of the NPs. The positively charged PtNPs with a size of ~12 nm were characterized by ultraviolet–visible spectroscopy (UV–Vis), dynamic light scattering (DLS), scanning electron microscopy (SEM), and X‐ray powder diffraction (XRD).
Dexamethasone leads to Zn2+ accumulation and increased unbound Zn2+ in C2C12 muscle and 3T3‐L1 adipose cells
Authors: Maier Michelle C. , Nankervis Scott , Wallace Morgan E. , Develyn Tamekha , Myers Mark A. 
Published: January 2023

AbstractSkeletal muscle atrophy is associated with increases in circulating glucocorticoid levels and insulin resistance. Zinc accumulates in atrophic muscle, but the relationship between atrophy, insulin resistance, and Zn2+ homeostasis remains unclear. In this study, the effect of the glucocorticoid dexamethasone (DEX) on insulin and Zn2+ homeostasis was explored. Treatment of differentiated C2C12 skeletal myotubes and 3T3‐L1 adipocytes with DEX significantly increased mRNA expression of the metal‐binding proteins Mt1 and 2 and altered energy storage as shown by the increased size of lipid droplets in 3T3‐L1 cells. In C2C12 cells the total cellular Zn2+ was higher after DEX treatment, and in both C2C12 and 3T3‐L1 adipocytes, free unbound Zn2+ was increased. Insulin treatment led to a gradual increase in free Zn2+ in C2C12 cells, and no significant change in DEX‐treated cells such that concentrations were similar 10 min after insulin treatment. These data demonstrate that DEX disturbs Zn2+ homeostasis in muscle and fat cells. Further study of the molecular pathways involved to identify novel therapeutic targets for treatment of skeletal muscle atrophy is warranted.
Murburn posttranslational modifications of proteins: Cellular redox processes and murzyme‐mediated metabolo‐proteomics
Authors: Manoj Kelath Murali 
Published: January 2023

AbstractMurburn concept constitutes the thesis that diffusible reactive species or DRS are obligatorily involved in routine metabolic and physiological activities. Murzymes are defined as biomolecules/proteins that generate/modulate/sustain/utilize DRS. Murburn posttranslational modifications (PTMs) result because murburn/murzyme functionalism is integral to cellular existence. Cells must incorporate the inherently stochastic nature of operations mediated by DRS. Due to the earlier/inertial stigmatic perception that DRS are mere agents of chaos, several such outcomes were either understood as deterministic modulations sponsored by house‐keeping enzymes or deemed as unregulated nonenzymatic events resulting out of “oxidative stress”. In the current review, I dispel the myths around DRS‐functions, and undertake systematic parsing and analyses of murburn modifications of proteins. Although it is impossible to demarcate all PTMs into the classical or murburn modalities, telltale signs of the latter are evident from the relative inaccessibility of the locus, non‐specificities and mechanistic details. It is pointed out that while many murburn PTMs may be harmless, some others could have deleterious or beneficial physiological implications. Some details of reversible/irreversible modifications of amino acid residues and cofactors that may be subjected to phosphorylation, halogenation, glycosylation, alkylation/acetylation, hydroxylation/oxidation, etc. are listed, along with citations of select proteins where such modifications have been reported. The contexts of these modifications and their significance in (patho)physiology/aging and therapy are also presented. With more balanced explorations and statistically verified data, a definitive understanding of normal versus pathological contexts of murburn modifications would be obtainable in the future.
Comparison of shear wave elastography with gray‐scale USG and CT for quantitative evaluation of rectus femoris muscle
Authors: Yi Jisook , Cha Jang Gyu , Hahn Seok 
Published: January 2023

AbstractPurposeThe purpose of this study was to compare the measurement of shear wave elastography (SWE) and gray scale ultrasonography (GSU) and CT attenuation of mid‐rectus femoris (RF) muscle in healthy adults.MethodsThis prospective study included 70 participants with a healthy body mass index (<25 kg/m2) between June 2019 and January 2020. Echo intensity (EI) grading of RF on GSU was performed. SWE was performed for the three levels of the RF. Measurements were repeated 10 min after the first measurement. The mid‐RF attenuation on CT was also measured. Interobserver agreement of EI grade among three readers was assessed using weighted‐kappa statistics. The reliability of SWE was assessed using intraclass correlation coefficient. The correlations between the SWE and CT/GSU measurements were analyzed.ResultsInterobserver agreement of EI grade on GSU by the three radiologists was moderate to substantial (k = 0.562–0.767). The inter‐session agreements for SWE were almost perfect for mid RF (k = 0.822–0.829) and substantial for proximal and distal RF (k = 0.767–0.795). There were significant correlations between SWE‐EI and SWE‐CT attenuation (p < 0.001, respectively) at the mid‐RF.ConclusionsSWE measurements on mid‐RF demonstrated the highest reliability. SWE parameters showed a strong correlation with EI on GSU and attenuation on CT.
Characterization of the structural and mechanical properties of pinecone fish (Monocentris japonica) scales
Authors: Guo Mingzhuo , Wu Siyang , Zhao Jiale , Zhuang Jian , Wu Qian 
Published: January 2023

AbstractIn this paper, the microstructure characteristics and mechanical properties (including nano‐indentation, tensile, and penetration behaviors) of the scales from pinecone fish (Monocentris japonica) were investigated. The M. japonica scales display a unique hierarchical structure and consist of three layers: an outer bone layer with high mineralization, an intermediate bone layer with obvious pore structures, and an inner collagen layer composed of multiple plies of collagen fibers. The hardness and indentation modulus of the three structural layers exhibit gradient changes, and decrease gradually from the outer layer to the inner layer. Tensile tests show that the tensile response and failure modes of the scales are different under dry and hydrated conditions. The dry scales have higher tensile strength (46.35 MPa) and Young's modulus (0.74 GPa), while the hydrated scales exhibit higher ultimate strain (20.18%) and toughness (4.57 MPa). Penetration tests indicate that the scales have a significantly high resistance to penetration, and increase the penetration force by more than six times compared with the descaled skin. Furthermore, the structure–property relationship of the M. japonica scales was discussed. It is found that the hard outer layer and the porous intermediate layer help to disperse the stress, and the soft inner layer containing collagen fiber plies helps to deflect the crack propagation, which are responsible for the excellent mechanical properties of the scales. The outcome of this study can provide a valuable biomimetic design inspiration for lightweight and high‐strength composite materials in engineering fields.Research Highlights
Microstructure characteristics and mechanical properties of the Monocentris japonica scales were investigated.
The M. japonica scales can be divided into three layers rather than two layers.
The M. japonica scales exhibited high tensile strength and penetration resistance.
Significance of pretreatment alpha‐fetoprotein in patients with compensated severe fibrosis after hepatitis C viral eradication
Authors: Ishigami Masatoshi , Honda Takashi , Ishizu Yoji , Imai Norihiro , Ito Takanori , Yamamoto Kenta , Kawashima Hiroki 
Published: January 2023

AbstractBackgroundWe aimed to investigate the factors associated with improvement of liver functional reserve after sustained virological response using interferon‐free, direct‐acting antiviral combination treatment in patients with compensated, severe fibrosis.MethodsBetween September 2014 and April 2020, 492 patients received direct‐acting antiviral combination treatment in our hospital. Among them, 173 patients who had severe fibrosis based on a fibrosis‐4 index ≥3.25, showed sustained virological response after treatment. We investigated the dynamic change in albumin‐bilirubin score and the baseline factors associated with its improvement, 48 weeks after treatment.ResultsThe baseline significant factors associated with albumin‐bilirubin ≦ −0.5 were lower albumin (HR: 15.625, 95% CI: 4.273–58.824, P < .001), higher hepatitis C virus RNA (HR: 4.995, 95% CI: 1.882–13.260, P = .001), and higher alpha‐fetoprotein (HR: 1.033, 95% CI: 1.011–1.055, P = .003). Patients with alpha‐fetoprotein ≧10 ng/mL showed significant improvement of albumin‐bilirubin score from baseline to 48 weeks after treatment compared to those with alpha‐fetoprotein <10 ng/mL (P < .001).ConclusionsBaseline serum alpha‐fetoprotein might be a predictive factor for improvement of liver function after sustained virological response in patients with severe fibrosis.
Methylene blue as a photo‐redox catalyst employed for the synthesis of pyrano[2,3‐d]pyrimidine scaffolds via a single‐electron transfer/energy transfer pathway
Authors: Mohamadpour Farzaneh 
Published: January 2023

AbstractThe radical tandem Knoevenagel‐Michael cyclocondensation reaction of barbituric acid/1,3‐dimethylbarbituric acid, malononitrile, and aryl aldehydes was used to establish a green tandem method for the metal‐free synthesis of pyrano[2,3‐d]pyrimidine scaffolds. At ambient temperature, photo‐excited state functions made from methylene blue (MB+) were used as single‐electron transfer and energy transfer catalysts in an aqueous solvent, utilizing visible light as a sustainable energy source. The purpose of this project is to enhance the use of a non‐metal cationic dye that is both affordable and widely available. Methylene blue is photochemically catalyzed with the least amount of catalyst feasible, yielding excellent yields, energy efficiency, and environmental friendliness, as well as excellent atom economy, time‐saving features, and ease of operation. As a result, a wide range of environmental and long‐term chemical properties can be obtained. The pyrano[2,3‐d]pyrimidine scaffolds' turnover number and turnover frequency have been calculated. Surprisingly, gram‐scale cyclization is conceivable, indicating that the technology could be used in industry.
Inequality and the middle‐income trap
Authors: Hu Xiaoshan , Wan Guanghua , Yang Chen , Zhang Anqi 
Published: January 2023

AbstractThis paper proposes an indicator measuring the likelihood for an economy to escape the middle income trap (MIT) and then estimates the impact of income inequality on this indicator using 1960‐2019 cross‐country data. Major findings include the following: (1) The likelihood of escaping MIT is relatively large for Asia, followed by Europe, Africa, North America and South America. (2) Inequality is negatively and significantly correlated with the MIT indicator, particularly in freer, high‐income and MIT country groups. (3) Regarding the mechanisms, domestic investment, human capital accumulation and trade openness contribute positively to this indicator, while ageing does the opposite.
Dust emission and potential diffusion process in Mongolia
Authors: Chen Zhuo , Gao Xin , Lei Jiaqiang 
Published: January 2023

AbstractMongolian dust is an important part of Asian aerosols, which highly influences regional ecological balance and atmospheric environment cycling. Detailed and systematic research is essential for downwind countries of Mongolia to formulate appropriate strategies for dust disaster prevention. In this study, a size‐resolved dust emission scheme and a hybrid single‐particle Lagrangian integrated trajectory model were coupled to reproduce the Mongolian dust events. For the dust storm that occurred on March 14, 2021, the simulated dust source was mainly located in the Gobi Provinces and a narrow strip between the Altai and Khangai Mountains. The potential diffusion area of dust was approximately 8.59 × 106 km2. The long‐term simulation between 2001 and 2020 shows that Mongolian dust sources can be divided into three areas: southwest Mongolia, the Gobi Provinces, and the area between the Altai and Khangai Mountains. Dust emissions can reach 100.6 Tg year−1, affecting approximately 12.6 × 106 km2 of land in East Asia. The emission and transport characteristics of Mongolian dust vary according to the sources. Southwestern Mongolia has the most severe dust emissions and the Gobi Provinces have the strongest diffusion capacity. Southern Mongolia and northern China have always been the hotspots of Mongolian dust transportation and deposition and thus require more research attention. This study provides a comprehensive analysis of Mongolian dust and presents a potential diffusion map that can be used to formulate preventive measures.
Outside the library: Early career researchers and use of alternative information sources in pandemic times
Authors: Herman Eti , Nicholas David , Clark David , Boukacem‐Zeghmouri Chérifa , Rodríguez‐Bravo Blanca , Abrizah Abdullah , Sims David , Watkinson Anthony , Xu Jie , Serbina Galina , Świgoń Marzena , Jamali Hamid R. , Tenopir Carol , Allard Suzie 
Published: January 2023

AbstractPresents findings from a study into the attitudes and practices of pandemic‐era early career researchers (ECRs) in regard to obtaining access to the formally published scholarly literature, which focused on alternative providers, notably ResearchGate and Sci‐Hub. The study is a part of the Harbingers project that has been exploring the work lives and scholarly communication practices of ECRs in pre‐pandemic times and during the pandemic, and utilizes data from two rounds of interviews with around 170 ECRs from the sciences and social sciences in eight countries. Findings show that alternative providers, as represented by ResearchGate and Sci‐Hub, have become established and appear to be gaining ground. However, there are considerable country‐ and discipline‐associated differences. ECRs' country‐specific level of usage of the alternative providers is partly traceable to the adequacy of library provisions, although there are other factors at play in shaping ECRs' attitudes and practices, most notably convenience and time saving, as well as the fact that these platforms have become embedded in the scholarly dashboard. There is a dearth of evidence of the impact of the pandemic on ECRs' ways of obtaining scholarly papers.
Mapping length of inpatient treatment duration and year‐wise relapse rates in eating disordered populations in a well‐defined Western‐European healthcare region across 1998–2020
Authors: Andersson Peter , Jamshidi Esmail , Ekman Carl‐Johan , Tedroff Kristina , Björkander Jonnie , Sjögren Magnus , Lundberg Johan , Jokinen Jussi , Desai Boström Adrian E. 
Published: January 2023

AbstractObjectivesUpdated international guideline recommendations for AN inpatient care rely on expert opinions/observational evidence and promote extended inpatient stays, warranting investigation using higher‐level ecological evidence.MethodsThe study was conducted according to Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Data encompassing 13,885 ED inpatients (5336 adolescents and 8549 adults) was retrieved from Swedish public health registries. Variables analyzed included (1) ED inpatient care opportunities, (2) unique number of ED inpatients and (3) mean length of ED‐related inpatient stays in age groups 15–19 and 20–88+, across 1998–2020.ResultsMean length of inpatient stays was inversely correlated to relapse to ED‐related inpatient care within the same year (p < 0.001, R‐squaredadj = 0.5216 and p < 0.00001, R‐squaredadj = 0.5090, in the 15–19 and 20–88+ age groups, respectively), independent of number of ED inpatients treated within a year in both age groups. Extending mean adolescent inpatient duration from 35 to 45 days was associated with a ∼30% reduction in the year‐wise relapse rate.ConclusionsMean length of ED‐related inpatient treatment stays was associated with reduced relapses to inpatient care within the same year, which could be interpreted as support for recommendations to include a stabilization phase in inpatient ED treatment.
Revisiting the empirical particle‐fluid coupling model used in DEM‐CFD by high‐resolution DEM‐LBM‐IMB simulations: A 2D perspective
Authors: Zeng Zhixiong , Fu Jinlong , Feng Y. T. , Wang Min 
Published: January 2023

AbstractThe work investigates the applicability of the unresolved Computational Fluid Dynamics and Discrete Element Method (CFDDEM) technique based on empirical equations for fluid‐particle coupling. We first carry out a series of representative volume element simulations using the high‐resolution particle‐resolved Lattice Boltzmann method and Discrete Element Method (LBMDEM) coupled by an Immersed Moving Boundary (IMB) scheme. Then, we compare the results obtained by both LBMDEM and empirical equations used in unresolved CFDDEM with analytical solutions. It is found that the existing empirical equations used in solving fluid‐particle interactions in 2D CFDDEM fail to accurately calculate the hydrodynamic force applied to solid particles. The underlying reason is that the existing empirical models are obtained based on 3D experimental results and thus are not applicable to 2D problems. Based on the simulation results, a new drag coefficient model is then proposed. The estimated drag forces using the new model are compared favourably with the simulated ones, indicating the good performance of the proposed model.
Stress response and influencing factors among fever outpatients and children's families during normalisation of the COVID‐19 epidemic: A cross‐sectional study
Authors: Lu Lifen , Zheng Gui , He Jiangqin , Wu Hui , He Xueqian , Yu Huajun , Wu Siying , Shen Xiulan 
Published: January 2023

AbstractAimTo examine the demographic characteristics associated with stress response of fever outpatients and children's families during normalisation of the COVID‐19 epidemic and to examine the relationship between stress response, coping style and resilience.DesignOnline cross‐sectional study.MethodsA total of 541 fever clinic participants from Yiwu, China, were recruited via WeChat from February to November 2021. Online self‐administered questionnaires were used to collect data. Data were analysed using t‐tests, one‐way analyses of variance, Pearson's correlation analyses and multiple linear regression analyses.ResultsThere were apparent physical and emotional responses among the fever outpatients, especially the adult patients. The main coping style was negative coping, and the degree of psychological resilience was low. Income, comorbidities, religious beliefs, tenacity, negative coping and positive coping were independent predictors of stress response.
Event‐triggered adaptive dynamic programming of nonlinear system with asymmetric input constraints and uncertain disturbances
Authors: Liu Yan , Qiu Guoqing , Gou Wenyao , Liu Qie 
Published: January 2023

AbstractIn this article, an uncertain disturbance rejection control problem for the affine system in the presence of asymmetric input constraints is addressed using an event‐triggered control method. The disturbance rejection control is converted to an optimal control problem, and a zero‐sum game‐based method is proposed to solve this optimal control problem. To deal with the input constraints, a new cost function is proposed. The event‐triggered controller is updated only when the triggering condition is satisfied, which can reduce the computational complexity.In order to obtain a controller that minimizes the performance index function in the worst‐case disturbance, we use a critic‐only network to solve the Hamilton–Jacobi–Isaacs (HJI) equation, and the critic network weight is tuned through a gradient descent method with the historical state data. The stability of the closed‐loop system and the uniform ultimate boundedness of the critic network parameters are proved by the Lyapunov method. Two numerical examples are provided to verify the effectiveness of the proposed methods.