bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple procedure to identify children with B‐lineage acute lymphoblastic leukemia who can be successfully treated with low or moderate intensity: Sequential versus single‐point minimal residual disease measurement
Authors: Popov Alexander , Henze Guenter , Roumiantseva Julia , Budanov Oleg , Belevtsev Mikhail , Verzhbitskaya Tatiana , Boyakova Elena , Movchan Liudmila , Tsaur Grigory , Fadeeva Maria , Lagoyko Svetlana , Zharikova Liudmila , Miakova Natalia , Litvinov Dmitry , Khlebnikova Olga , Streneva Olga , Stolyarova Elena , Ponomareva Natalia , Novichkova Galina , Fechina Larisa , Aleinikova Olga , Karachunskiy Alexander 
Published: March 2023

AbstractSequential monitoring of minimal residual disease (MRD) by molecular techniques or multicolor flow cytometry (MFC) has emerged over the past two decades as the primary tool to optimize treatment in pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). The aim of our study was to compare the prognostic power of repeated MFC–MRD measurement with single‐point MRD assessment in children with BCP‐ALL treated with the reduced‐intensity protocol ALL‐MB 2008. Data from consecutive MFC–MRD at day 15 and day 36 (end of induction, EOI) were available for 507 children with Philadelphia‐negative BCP‐ALL. They were stratified into standard risk (SR, n = 265), intermediate risk (ImR, n = 211), and high risk (HR, n = 31) according to the initial clinical characteristics defined in the ALL‐MB 2008 protocol. Quantitative (relative to quantitative thresholds) and kinetic (logarithmic reduction) assessments of MFC–MRD at both time points effectively separated patients into three groups with different risk of recurrence. On the other hand, starting with low (for the SR group) and moderate (for the ImR group) induction therapy, a single MFC–MRD measurement at EOI proved sufficient to unequivocally identify patients in whom this therapy is highly effective and distinguish them from those who cannot be successfully treated with such therapy. Therefore, initiating treatment with low or moderate treatment from the start, together with careful consideration of initial clinical risk factors and just one EOI–MFC–MRD measurement is simple, inexpensive, and entirely sufficient for treatment optimization. Furthermore, for a large proportion of patients, this approach allows better adjustment, in particular also reduction of therapy intensity than sequential MRD measurements.
Extracellular vesicles released during hypoxia transport heparanase and enhance macrophage migration, endothelial tube formation and cancer cell stemness
Authors: Tripathi Kaushlendra , Bandari Shyam K. , Sanderson Ralph D. 
Published: March 2023

AbstractHeparanase is upregulated during the progression of most cancers and via its enzyme activity promotes extracellular matrix degradation, angiogenesis and cell migration. Heparanase expression is often associated with enhanced tumor aggressiveness and chemoresistance. We previously demonstrated that increased heparanase (HPSE) expression in tumor cells enhances secretion and alters the composition of tumor‐released exosomes. In the present study, we discovered that extracellular vesicles (EVs) secreted by human multiple myeloma cells growing in hypoxic conditions exhibited elevated levels of HPSE cargo compared to EVs from cells growing in normoxic conditions. When macrophages (RAW 264.7 monocyte/macrophage‐like cells) were exposed to EVs released by tumor cells growing in either hypoxic or normoxic conditions, macrophage migration and invasion was elevated by EVs from hypoxic conditions. The elevated invasion of macrophages was blocked by a monoclonal antibody that inhibits HPSE enzyme activity. Moreover, the HPSE‐bearing EVs from hypoxic cells greatly enhanced endothelial cell tube formation consistent with the known role of HPSE in promoting angiogenesis. EVs from hypoxic tumor cells when compared with EVs from normoxic cells also enhanced cancer stemness properties of both CAG and RPMI 8226 human myeloma cells. Together these data indicate that under hypoxic conditions, tumor cells secrete EVs having an elevated level of HPSE as cargo. These EVs can act on both tumor and nontumor cells, enhancing tumor progression and tumor cell stemness that likely supports chemoresistance and relapse of tumor.
The development and preliminary implementation evaluation of the Fear Of Recurrence Therapy intervention virtual training workshop
Authors: Lamarche Jani , Sehabi Ghizlène , Chu Alanna , Boudjatat Wassim Adlane , Giguère Lauriane , Langmuir Tori , Maheu Christine , Lebel Sophie 
Published: March 2023

Key points

Several fear of cancer recurrence (FCR) interventions have demonstrated their efficacy but are not yet implemented in routine clinical care.

Clinicians have expressed an interest in receiving FCR training, but access and availability are limited.

This paper reports on the evaluation of a 5h workshop over 2 days on the Fear Of Recurrence Therapy (FORT) intervention.

40 international psychosocial oncology clinicians were provided the workshop at no cost. Evaluation measures included feedback on the workshop, and preliminary outcome measures of their knowledge, self‐efficacy, usage, and implementation barriers/enablers.

Majority of participants utilized some or most of the FORT intervention. Results from the training indicate that it was effective, feasible and acceptable.
Oxymatrine suppresses colorectal cancer progression by inhibiting NLRP3 inflammasome activation through mitophagy induction in vitro and in vivo
Authors: Liang Li , Sun Weiliang , Wei Xiaoxuan , Wang Li , Ruan Huaqiang , Zhang Junchuan , Li Suyan , Zhao Bi , Li Mengshi , Cai Zhengwen , Huang Jie'an 
Published: March 2023

AbstractChinese herb Radix sophorae tonkinensis extract oxymatrine shows anticancer effects. This study evaluated the role of oxymatrine in colorectal cancer (CRC) and the underlying molecular events in vitro and in vivo. CRC cells were treated with different doses of oxymatrine to assess cell viability, reactive oxygen species production, gene expression, and gene alterations. Meanwhile, mouse xenograft and liver metastasis models were used to assess the effects of oxymatrine using histology examination, transmission electron microscopy, and Western blot, respectively. Our results showed that oxymatrine treatment triggered CRC cell mitophagy to inhibit CRC cell growth, migration, invasion, and metastasis in vitro and in vivo. At the gene level, oxymatrine inhibited LRPPRC to promote Parkin translocation into the mitochondria and reduce the mitophagy‐activated NLRP3 inflammasome. Thus, oxymatrine had an anticancer activity through LRPPRC inhibition, mitophagy induction, and NLRP3 inflammasome suppression in the CRC cell xenograft and liver metastasis models. In conclusion, the study demonstrates the oxymatrine anti‐ CRC activity through its unique role in regulating CRC cell mitophagy and NLRP3 inflammasome levels in vitro and in vivo.
Long‐term prognosis of focal segmental glomerulosclerosis treated with therapeutic low‐density lipoprotein‐apheresis in patients with severe kidney dysfunction and proteinuria
Authors: Kitajima Shinji , Osima Megumi , Ogura Hisayuki , Nakagawa Shiori , Yamamura Yuta , Miyake Taito , Miyagawa Taro , Toyama Tadashi , Hara Akinori , Sakai Norihiko , Shimizu Miho , Wada Takashi , Iwata Yasunori 
Published: March 2023

AbstractBackgroundThe prognosis of focal segmental glomerulosclerosis patients with nephrotic syndrome is estimated to be 10%–20% in 5 years and 30%–50% in 10 years, leading to end‐stage kidney disease. The response rate with steroid therapy is 40%–60%. Therapeutic low‐density lipoprotein‐apheresis (LDL‐A) may be effective in patients with steroid resistance. Information regarding the long‐term prognosis of patients with focal segmental glomerulosclerosis receiving this therapy is scarce.MethodsWe investigated the effectiveness of treatment in 50 patients with primary focal segmental glomerulosclerosis diagnosed between 1961 and 2017 at Kanazawa University Hospital and related facilities. The patients were observed at least 12 months after biopsy or until end‐stage kidney disease occurrence or death.ResultsLDL‐A was performed in four patients who presented with steroid‐resistant nephrotic syndrome (two patients had concurrent acute renal failure for which hemodialysis was performed). In comparison with 17 patients who did not receive LDL‐A after 1989, the LDL‐A group had higher urinary protein excretion (13.7 vs. 5.2 g/day, P = 0.053) and serum creatinine (4.11 vs. 1.65 mg/dL) levels at onset, and a numerically higher remission rate (75.0% vs. 58.7%) compared with the nonlipoprotein‐apheresis group.ConclusionTherapeutic LDL‐A can be performed for critical cases and may improve the remission rate.
Characterizing adaptive teaching expertise: Teacher profiles based on epistemic orientation and knowledge of epistemic tools
Authors: Suh Jee K. , Hand Brian , Dursun Jale E. , Lammert Catherine , Fulmer Gavin 
Published: March 2023

AbstractWith an ultimate goal of characterizing teachers' movement toward understanding the epistemic complexity of generative learning environments, this study refers to adaptive teaching expertise (AdTex) as a developmental teaching capacity observable through a teacher's ability to utilize various resources to address the epistemic complexity of knowledge generation practices. The analysis and discussions centered on how teachers develop and utilize epistemic orientation and understandings of epistemic tools for adaptive teaching, making this study distinct from previous research on AdTex. In particular, this study shows a new way to create systematic profiles of AdTex based on the multiple qualitative data sources, including vignettes, interviews, and reflections collected through a multiple‐case study with 24 teachers. The qualitative profile analysis suggests that the development of epistemic resources is closely related to teachers' attention to student ideas, student agency, and a balance between flexibility and productivity regardless of context. The analysis demonstrates that the development of epistemic resources can represent the degree of development of AdTex and provide a rich research pathway for future analysis.
Unpacking the sustainable development goals (SDGs) interlinkages: A semantic network analysis of the SDGs targets
Authors: Song Jaemin , Jang Chang‐Ho 
Published: March 2023

AbstractUnderstanding sustainable development goal (SDG) targets and their interlinkages is crucial for achieving national and local SDGs since policies must be designed and implemented at the target level rather than at the macro goal level. However, due to their extensive nature, it remains challenging to fully determine their interlinkages. This study aims to identify the interlinkages between the SDG targets, employing a semantic network analysis with text‐mining and Word2Vec machine‐learning methodology. The network analysis of the entire SDG target network reveals that each community of closely connected targets comprises targets from multiple SDG goals, while targets within the same SDG goal also belong to different communities. The findings indicate that the current framework of 17 SDG goals may not be a suitable basis for developing SDG policies. Instead, intersectoral strategies focusing on a community of interconnected targets that necessitate coordination based on their actual interlinkages are required.
The Effect of COVID-19 on Surgical Management of Skin Cancers of the Head, Face and Neck in Elderly Patients
Authors: Borg Tiffanie-Marie , Eisold Jessica , Miyanjo Yusuf , Pappa Elena 
Published: March 2023

Abstract

Background
The Corona Virus (COVID-19) has had a profound impact on healthcare systems worldwide, with interruptions to medical practices including the delivery of cancer treatment. Skin cancer is one of the leading causes of malignancy worldwide, with later stages of disease correlating to poorer prognosis. Immunocompromized and elderly patients represent populations that are at higher risk for adverse outcomes related to skin cancer, treatment delay and COVID-19 infection.

Methodology
Patients aged 65 and above who underwent surgical management of skin cancers from 31 January 2020 to 31 January 2021 were included in this study then compared with samples pre- and post-pandemic. Retrospective analysis was performed regarding: date of referral to date of surgery, skin cancer type, location of cancer, surgery performed, anaesthesia used, sutures used and outcomes. Data was compared to national guidelines.

Results
Five hundred and twenty skin cancers were included in this analysis, of which 340 were treated during the COVID-19 pandemic. Of the cohort treated during the pandemic, 44.2% (n = 111) received excision and direct closure, 13.1% (n = 33) underwent reconstruction by integra dermal substitute, 3.2% (n = 8) by split thickness skin graft, 6.4% (n = 16) by full thickness skin grafts and 33.1% (n = 83) by local flaps. Complete excision was achieved in 88.5% of cases (n = 301). The mean time from referral to surgery was 119 days. There were no deaths associated with COVID-19.

Conclusion
Safe and prompt treatment of head and neck skin cancers is achievable despite the COVID-19 pandemic. Measures to minimize infection risk include the use of teledermatology, reliable COVID-19 testing, Green Pathways and a reduction in the mean referral to surgery time.
Structural Engineering Enabled Bimetallic (Ti1‐yNby)2AlC Solid Solution Structure for Efficient Electromagnetic Wave Absorption in Gigahertz
Authors: Xu Tongtong , Li Jun , Zhao Dongpeng , Chen Xiping , Sun Guangai , Zhou Zhongxiang 
Published: March 2023

AbstractMicrostructures play a critical role to influence the polarization behavior of dielectric materials, which determines the electromagnetic response ability in gigahertz. However, the relationship between them, especially in the solid‐solution structures is still absent. Herein, a series of (Ti1‐yNby)2AlC MAX phase solid solutions with nano‐laminated structures have been employed to illuminate the aforementioned problem. The relationship has been investigated by the lattice distortion constructed via tuning the composition from Ti to Nb in the M‐site atomic layer. Experimental characterizations indicated that the dielectric response behaviors between declined conduction loss and boosted polarization loss can be well balanced by niobium atom manipulative solid‐solution engineering, which is conducive to impedance matching and electromagnetic absorption performance. Theoretical calculation further proved that the origin of electric dipoles is ascribed to the charge density differences resulting from the altered microscopic atomic distribution. As a result, the Ti1.2Nb0.8AlC exhibits the mostly optimized microwave absorption property, in which a minimum reflection loss of −42 dB and an effective absorption bandwidth of 4.3 GHz under an ultra‐thin thickness of 1.4 mm can be obtained. This work provides insight into the structural engineering in modifying electromagnetic response performance at gigahertz and which can be expanded to other solid‐solution materials.
Moiré Superlattice Structure in Two‐Dimensional Catalysts: Synthesis, Property and Activity
Authors: Wang Li , Yin Sisi , Yang Jianping , Dou Shi Xue 
Published: March 2023

AbstractTwo‐dimensional (2D) layered materials have been widely used as catalysts due to their high specific surface area, large fraction of uncoordinated surface atoms, and high charge carrier mobility. Moiré superlattice emerges in 2D layered materials with twist angle or lattice mismatch. By manipulating the moiré superlattice structure, 2D layered materials present modulated electronic band structure, topological edge states, and unconventional superconductivity which are tightly associated with the performance of catalysts. Hence, engineering moiré superlattice structures are proposed to be an important technology in modifying 2D layered materials for improved catalytic properties. However, currently, the investigation of moiré superlattice structure in a catalytic application is still in its infancy. This perspective starts with the discussion of structural features and fabrication strategy of 2D materials with moiré superlattice structure. Afterward, the catalytic applications, including electrocatalytic and photocatalytic applications, are summarized. In particular, the promotion mechanism of the catalytic performance caused by the moiré superlattice structure is proposed. Finally, the perspective is concluded by outlining the remaining challenges and possible solutions for the future development of 2D materials with moiré superlattice structure towards the catalytic applications.
Band Modification and Localized Lattice Engineering Leads to High Thermoelectric Performance in Ge and Bi Codoped SnTe–AgBiTe2 Alloys
Authors: Nie Chang , Wang Chong , Xu Yongjie , Liu Yuxin , Niu Xiaojian , Li Shuang , Gong Yaru , Hou Yunxiang , Zhang Xuemei , Zhang Dewei , Li Di , Zhang Yongsheng , Tang Guodong 
Published: March 2023

AbstractSnTe, emerging as an environment‐friendly alternative to conventional PbTe thermoelectrics, has drawn significant attention for clean energy conversion. Here, a high peak figure of merit (ZT) of 1.45 at 873 K in Ge/Bi codoped SnTe–AgBiTe2 alloys is reported. It is demonstrated that the existence of Ge, Bi, and Ag facilitate band convergence in SnTe, resulting in remarkable enhancement of Seebeck coefficient and power factor. Simultaneously, localized lattice imperfections including dislocations, point defects, and micro/nanopore structures are caused by incorporation of Ge, Bi, and Ag, which can effectively scatter heat carrying phonons with different wavelengths and contribute to an extremely low κL of 0.61 W m−1 K−1 in Sn0.92Ge0.04Bi0.04Te–10%AgBiTe2. Such high peak ZT is achieved by decouples electron and phonon transport through band modification and localized lattice engineering, highlighting promising solutions for advancing thermoelectrics.
Chiral Bisphosphoric Acids and Their Applications in Asymmetric Catalysis
Authors: Han Zhi‐Yong , Gong Liu‐Zhu 
Published: March 2023

AbstractAsymmetric Brønsted acid catalysis has been recognized as a powerful concept for asymmetric synthesis. In the process of pursuing more robust and highly effective chiral Brønsted acid catalysts, chiral bisphosphoric acids have received much attention in the last two decades. Their unique catalytic properties are mainly attributed to the inherent intramolecular hydrogen bonding interactions that could increase the overall acidity and tune the conformation property. Integrating hydrogen bonding into the catalyst design, quite a few structurally unique and effective bisphosphoric acids have been synthesized, which frequently exhibited superior selectivity in a broad range of asymmetric transformations. This review summarizes the status quo of chiral bisphosphoric acid catalysts and their applications in catalyzing asymmetric transformations.
Efficacy of autonomous recording units to evaluate wild turkey gobbling chronology in North Carolina, USA
Authors: Kreh Christopher D. , Pease Brent S. , Pacifici Krishna 
Published: March 2023

AbstractWild turkey (Meleagris gallopavo)gobbling is a key component of hunter satisfaction, also providing insight into the underlying reproductive ecology of wild turkeys that can inform regulatory decisions. However, monitoring gobbling chronology over large geographic areas can be logistically challenging and identifying efficient monitoring schemes can help wildlife agencies better manage the species. We evaluated the efficacy and utility of autonomous recording units (ARUs) to detect wild turkey gobbles and deployed 51 ARUs to monitor gobbling chronology in North Carolina, USA. We conducted controlled field‐tests at 20 locations to compare how detection of gobbles differed by ARU software, manual review of ARUs, and in‐field human observers. Autonomous detections had the lowest probability, with detection probabilities approaching 0 at 300 m from the ARU. Autonomous detections of gobbles were affected by leaf‐on conditions and topographical interference while vegetation type surrounding ARUs had minimal and inconsistent effects on detection. We deployed ARUs on properties with little or no turkey hunting across North Carolina from March–May during 2016 through 2019 to explore annual and regional variation in gobbling chronology. We used ARUs to monitor gobbling chronology and recorded 53,943 hours of audio files from which we confirmed 113,737 gobbles out of a total of 602,053 possible sound events identified. We identified multimodal gobbling chronology across 3 primary physiographic regions in North Carolina. We also found comparable timing of gobbling chronology across the 3 regions, with 57–61% of gobbling occurring during the weeks in which hunting seasons occur. We recommend that researchers validate ARU performance to calibrate monitoring of gobbling chronology. Additionally, our gobbling chronology data suggest that a statewide framework, rather than a regionally split framework, is appropriate for wild turkey hunting in North Carolina.
A U-spin anomaly in charm CP violation
Authors: Schacht Stefan 
Published: March 2023

Abstract
Recent LHCb data shows that the direct CP asymmetries of the decay modes D0 → π+π− and D0 → K+K− have the same sign, violating an improved U-spin limit sum rule in an unexpected way at 2.1σ. From the new data, we determine for the first time the imaginary part of the CKM-subleading, U-spin breaking ∆U = 1 correction to the U-spin limit ∆U = 0 amplitude. The imaginary part of the ∆U = 0 amplitude is determined by $$ \Delta {a}_{\textrm{CP}}^{\textrm{dir}} $$
∆

a
CP
dir

. The corresponding strong phases are yet unknown and could be extracted in the future from time-dependent measurements. Assuming $$ \mathcal{O}(1) $$
O

1

strong phases due to non-perturbative rescattering, we find the ratio of U-spin breaking to U-spin limit contributions to the CKM-subleading amplitudes to be $$ \left({173}_{\hbox{--} 74}^{+85}\right)\% $$

173

–
74

+
85

%
. This highly exceeds the Standard Model (SM) expectation of ~ 30% U -spin breaking, with a significance of 1.95σ. If this puzzle is confirmed with more data in the future, in the SM it would imply the breakdown of the U -spin expansion in CKM-subleading amplitudes of charm decays. The other solution are new physics models that generate an additional ∆U = 1 operator, leaving the U-spin power expansion intact. Examples for the latter option are an extended scalar sector or flavorful Z′ models.
Holographic Characterisation of Locally Anti-de Sitter Spacetimes
Authors: McGill Alex 
Published: March 2023

AbstractIt is shown that an $$(n+1)$$

(
n
+
1
)

-dimensional asymptotically anti-de Sitter solution of the Einstein-vacuum equations is locally isometric to pure anti-de Sitter spacetime near a region of the conformal boundary if and only if the boundary metric is conformally flat and (for $$n \ne 4$$

n
≠
4

) the boundary stress–energy tensor vanishes, subject to (i) sufficient (finite) regularity in the metric and (ii) the satisfaction of a conformally invariant geometric criterion on the boundary region. A key tool in the proof is the Carleman estimate of Chatzikaleas and Shao (Commun Math Phys, 2022)—a generalisation of previous work by the author with McGill and Shao in (Class Quant Gravity 38(5), 2020)—which is applied to prove a unique continuation result for the Weyl curvature at the conformal boundary given vanishing to sufficiently high order over the boundary region.