bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human-Centered Design and Iterative Refinement of Tools and Methods to Implement a Surveillance and Risk Prediction System for Clinical Deterioration in Ambulatory Cancer Care
Authors: France Daniel J. , Nath Paromita , Slagle Jason , Anders Shilo , Salwei Megan , Vogus Timothy , Slater Hannah , Reale Carrie , Novak Laurie , Parker-Danley Lori-Anne , Kohutek Zachary , Agarwal Rajiv , Harris Joyce , Yudiskas Barbara , Conwill Ralph , Smith Terrell , Rhodes Evan , Schremp Emma , Gillaspie Erin A. , Wright Adam , Freundlich Robert E. , Myles Ryan , Faiman Janelle , Mahadevan Sankaran , Weinger Matthew 
Published: February 2025

Abstract
Background A common cause of preventable harm is the failure to detect and appropriately respond to clinical deterioration. Timely intervention is needed, particularly in medically complex patients, to mitigate the effects of adverse events, disease progression, and medical error. This challenging problem requires clinical surveillance, early recognition, timely notification of the appropriate clinicians, and effective intervention.
Objectives We determined the feasibility of designing, developing, and implementing the tools and processes to create a surveillance-and-risk prediction system to detect clinical deterioration in cancer outpatients.
Methods We used systems engineering and iterative human-centered design to develop a functional prototype of a surveillance-and-risk prediction system. The system includes passive surveillance involving wearable sensors, active surveillance involving patient event and symptom reporting as well as extraction of selected patient data from the electronic health record (EHR), a predictive model, and communication of estimated risk to clinicians. System usability was evaluated using patient and clinician interviews and clinician ratings using the System Usability Scale (SUS).
Results Fifty of 71 recruited patients enrolled in the feasibility study. Patient-reported outcome measures and clinical data extracted from the EHR were the best predictors of a patient's 7-day risk of experiencing unplanned treatment events (UTEs, i.e., emergency room visits, hospital admissions, or major treatment changes). Deep learning neural network models using these predictors demonstrated modest performance in predicting 7-day UTE risk (PROMS, F-measure: 0.900, area under the receiver operating characteristic curve [AUC-ROC]: 0.983; clinical data from EHR F-measure: 0.625, AUC-ROC: 0.983). Patient risk scores were communicated to clinicians using a risk communication prototype rated favorably by clinicians with a SUS score of 76 out of 100 (median = 80; range: 60–85).
Conclusion We demonstrate the feasibility of a surveillance-and-risk prediction system for detecting and reporting clinical deterioration in cancer outpatients. Future research is needed to fully implement and evaluate system adoption and effectiveness under different clinical situations.
Outcome of Arthroscopic Dorsal Peripheral Repairs of the Triangular Fibrocartilage with a Positive Hook Test and an Intact Foveal Ligament
Authors: Ecker Jeff , Pavleski Karolina , de Jong Jess , Jones Zoe , Andrijich Courtney 
Published: February 2025

Abstract
Background This study was performed to determine whether an arthroscopic dorsal peripheral triangular fibrocartilage complex (TFCC) repair can stabilize symptomatic distal radioulnar joint (DRUJ) instability in patients with a positive hook test, an intact foveal insertion, and a dorsal peripheral detachment of the TFCC.
Materials and Methods All patients who had an isolated arthroscopic dorsal peripheral TFCC repair performed by the primary author between August 2018 and April 2023 were included in the study. Functional measures of range of motion (ROM), gross grip, lateral pinch, force plate, pronation strength, supination strength, visual analogue scale (VAS) at rest, VAS on use, patient rated wrist evaluation (PRWE), and disabilities of the arm, shoulder, and hand (DASH) were recorded pre- and postoperatively.
Results For this study 31 patients met the inclusion criteria. Measures taken at a mean of 13.8 months post-surgery demonstrated improvement in all functional parameters, with the exception of ulnar deviation and pronation which remained unchanged. Resolution of symptomatic DRUJ instability was documented in all cases. There were no cases of recurrent instability. There were no complications.
Conclusions Arthroscopic dorsal TFCC repair can successfully resolve symptomatic DRUJ instability in patients with a positive hook test, a dorsal peripheral detachment of the TFCC, and an intact foveal insertion.
Level of Evidence I-4
The Effect of Episiotomy Applied in Vaginal Delivery on Breastfeeding
Self-Efficacy and Mother-Infant Attachment in the Postpartum
Period
Authors: Yılmaz Esencan Tuğba , Yıldırım Ayça Demir , Yıldız Mehtap 
Published: February 2025

Abstract
Objective  The aim of this study was to examine the effect of episiotomy
applied in vaginal delivery on breastfeeding self-efficacy and mother-infant
attachment in the postpartum period.
Methods  This descriptive study includes 110 puerperal women who were
registered in 3 family health centers in a district in Istanbul between July and
December 2022 and had a vaginal delivery. Data was collected using a descriptive
information form, maternal bonding scale and postpartum breastfeeding
self-efficacy scale.
Results  The mean age of the participants was 30.04±5.13 years. 61.9% of
the puerperal women were multiparous, the mean gestational age at delivery was
39±1.21 weeks, and 72.7% had an episiotomy at delivery. There was a
statistically significant correlation between the number of deliveries, having
problems during labor, and episiotomy application (p=0.005, p=0.044). There was
no statistically significant difference between the maternal bonding scale
scores and postpartumbreastfeeding self-efficacy scale scores of women who
underwent episiotomy at delivery and women who did not.
Conclusion  Episiotomy alone had no effect on maternal bonding and
postpartum breastfeeding self-efficacy, and episiotomy-induced pain was found to
be an effective factor in the postpartum period.
Analogues of the Potent and Selective ERβ Agonist trans-4-(4-Hydroxyphenyl)cyclohexanemethanol: Synthesis and Evaluation
Authors: Donaldson William A. , Chaudhury Subhabrata , Wetzel Edward A. , Elmansy Mohamed F. , Hanson Alicia M. , Brown-Ford Sandra , Gleason Alexandra , Perera K. L. Iresha Sampathi , Sem Daniel S. 
Published: February 2025

AbstractActivation of estrogen receptor-beta (ERβ) has potential benefits for vasomotor symptoms as well as memory consolidation in menopausal women. Ten 4-(4-substituted cyclohexyl)phenols were synthesized and evaluated as ERβ agonists in a TR-FRET ligand displacement assay. Four of the more potent compounds, all of which contained fluoroalkyl groups as the 4-substituent, were further assessed for agonist and antagonist activity in cell-based functional assays for ERβ and ERα. The 4-(4-fluoroalkyl-cyclohexyl)phenols were all >50-fold selective for ERβ over ERα, and none were found to be antagonists for either ERβ or ERα at 7,250 nM. Detection of 200 μM of trans-4-(4-(fluoromethyl)cyclohexyl)phenol in the presence of mouse brain homogenate was possible by 19F NMR spectroscopy.
Functional Assessment of Congenital Radioulnar Synostosis in Children
Authors: Moghamis Isam Sami , Abuhejleh Hasan , Abuodeh Yousef , Nasef Hazem Mohamad , Thanaraj Harris Manova , Preez Ilse Du , Kawas Mohamad Alaa 
Published: February 2025

Abstract
Background Congenital radioulnar synostosis (CRUS) is a rare condition caused by segmentation failure in embryonic life. The forearm is usually fixed in pronation, affecting the upper limb and hand functions. Treatment ranges from observation to surgical options to restore limb function and prevent disease recurrence. The study aimed to assess the functional outcome of patients with CRUS.
Methods We conducted a prospective evaluation of eight patients with CRUS between 2010 and 2020. The data involved history, physical examination, and functional assessment using the ABILHAND-Kids functional scale to determine children's adaptation to this deformity and the indication for surgical management. A control sample of four patients was included in the study for comparison.
Results Eight patients with 11 limb deformities were included in the study. The affected limbs' range of motion (ROM) was compared with the ROM of the unaffected limbs and the control patients. There were no statistically significant differences in ROM between the two groups except for fixed pronation deformity of the synostosis (p = 0.0133). The average ABILHAND-Kids score for all children was 38.625 ± 3.021, close to the average score of 42. Only one patient with bilateral involvement underwent surgical correction of the deformity 5 years from the initial presentation.
Conclusion CRUS is a rare congenital condition that can affect daily living activities. Surgical correction is rarely indicated and is only preserved for patients with bilateral involvement and significant functional impairment.
“You will be defeated by a tripod and a camera:” Sedat Peker and the antihero narrative in contemporary politics
Authors: Altınordu Ateş 
Published: February 2025

Abstract
In May and June of 2021, a series of YouTube videos posted by Sedat Peker, a Turkish crime boss, disclosed inside information implicating senior government officials and other public figures in major corruption scandals and crimes. Peker quickly gained popularity and became for the opposition a symbol of the impending fall of the Erdoğan regime. Based on a systematic analysis of these videos and the public debate they engendered, this article argues that the efficacy of Peker’s political campaign depended as much on the stylistic elements and cultural references of his performances as on the grave nature of his allegations about public officials. By showing how the antihero narrative—a genre ubiquitous in contemporary popular culture—is put to use in political performances, the study fills an important gap in narrative genre analysis in cultural sociology.
Resource productivity and sustainability—a comparison of two European countries
Authors: Malatyinszki Szilárd , Zéman Zoltán , Kálmán Botond Géza 
Published: February 2025

Abstract
This research analyzes resource productivity by identifying key elements and their effects. The goal is to examine resource productivity and GDP-DMC correlations in EU member states, notably Hungary and the Netherlands. Researchers selected Eurostat sustainability statistics based on literature. Regression and path models were used to examine the data. GDP is strongly influenced by DMC, according to the research. The research also found that circular material usage might unexpectedly increase material consumption and lower national GDP. The ratio of GDP to DMC, Resource Productivity, oversimplifies sustainability analysis since its numerator and denominator are not independent. SEM showed that GDP and DMC are not separately explained. GDP is the only evident dependent variable, according to this study. The findings show that understanding the complex relationship between material use and economic production is essential to improving resource productivity and sustainability. Hungary and the Netherlands must develop measures to boost resource productivity while balancing economic development and environmental sustainability.
Refashioning linguistic expertise: Translanguaging TESOL in social media
Authors: Lee Tong King , Wei Li 
Published: February 2025

Abstract
This article examines the performative reconfiguration of linguistic expertise and the mode of TESOL at the intersection of language teaching, networked technology, and the culture of ludification. Applying van Dijck and Alinejad’s (2020 ‘Social media and trust in scientific expertise: Debating the COVID-19 pandemic in The Netherlands’, Social Media + Society, 6/4) distinction of institutional versus networked models of communication, it addresses the shifting ecology of foreign language education in an age of digital platforms in which linguistic expertise is no longer the exclusive preserve of institutional establishments, but rather can be claimed or self-professed by individuals operating on the basis of multiplex networks. A case example of networked TESOL in social media is presented to explore how the affordances of the networked model give rise to a radically different teacher-student dynamic than in the standard classroom, speaking to the idea of translanguaging pedagogy. The article discusses the implications of networked TESOL for theory and practice in applied linguistics in the post-multilingual era, proposing the idea of ludic literacy, where the instructor-influencer’s persona tends toward the performative and the sardonic, and where resources are flexibly orchestrated across the boundaries of languages, modes, and media.
A new ensemble learning method stratified sampling Blending (ssBlending) optimizes conventional blending and improves prediction performance
Authors: Miao Na , Yang Mengke , Han Pingping , Qiao Jiakun , Che Zhaoxun , Xu Fangjun , Dai Xiangyu , Zhu Mengjin 
Published: February 2025

Abstract

Motivation
Ensemble learning, as a powerful machine learning method, improves overall prediction performance by combining the prediction results of multiple base models. Blending, as a popular ensemble learning method, can train multiple base models, input the resulting prediction results to further train meta model and obtain final prediction results. However, conventional blending divides the training set by simple random sampling, which causes bias and large variance, thus affecting the stability and accuracy of prediction performance. In this study, we propose a new algorithm of stratified sampling blending (ssBlending), which addresses the algorithm instability of conventional blending caused by the random partition of the training set, further improving the prediction accuracy.

Results
We used multiple genotype data sets from different species including animal (pig), plant (loblolly pine), and microorganism (yeast) to test the prediction performance of ssBlending. The across-species multi-dataset verification results reveal that ssBlending is superior to conventional blending in terms of prediction accuracy and stability. In addition, we optimized the training set sampling rate (BestH) to facilitate the practical application of the ssBlending algorithm. In summary, this study proposes a completely new algorithm combing stratification strategy with the conventional blending, which provides more options for ensemble learning in various fields.

Availability and implementation
https://figshare.com/s/23122a18dc8a35f12ff6
AskBeacon—Performing genomic data exchange and analytics with natural language
Authors: Wickramarachchi Anuradha , Tonni Shakila , Majumdar Sonali , Karimi Sarvnaz , Kõks Sulev , Hosking Brendan , Rambla Jordi , Twine Natalie A , Jain Yatish , Bauer Denis C 
Published: February 2025

Abstract

Motivation
Enabling clinicians and researchers to directly interact with global genomic data resources by removing technological barriers is vital for medical genomics. AskBeacon enables Large Language Models to be applied to securely shared cohorts via the GA4GH Beacon protocol. By simply “asking” Beacon, actionable insights can be gained, analyzed and made publication-ready.

Results
In the Parkinson's Progression Markers Initiative (PPMI) we use natural language to ask whether the sex-differences observed in Parkinson's disease are due to X-linked or autosomal markers. AskBeacon returns a publication-ready visualization showing that for PPMI the autosomal marker occurred 1.4 times more often in males with Parkinson’s disease than females, compared to no differences for the X-linked marker. We evaluate commercial and open-weight LLM models, as well as different architectures to identify the best strategy for translating research questions to Beacon queries. AskBeacon implements extensive safety guardrails to ensure that genomic data is not exposed to the LLM directly, and that generated code for data extraction, analysis and visualization process is sanitized and hallucination resistant, so data cannot be leaked or falsified.

Availability
AskBeacon is available at https://github.com/aehrc/AskBeacon.

Supplementary information
Supplementary data are available at Bioinformatics online.
AsaruSim: a single-cell and spatial RNA-Seq Nanopore long-reads simulation workflow
Authors: Hamraoui Ali , Jourdren Laurent , Thomas-Chollier Morgane 
Published: February 2025

Abstract

Motivation
The combination of long-read sequencing technologies like Oxford Nanopore with single-cell RNA sequencing (scRNAseq) assays enables the detailed exploration of transcriptomic complexity, including isoform detection and quantification, by capturing full-length cDNAs. However, challenges remain, including the lack of advanced simulation tools that can effectively mimic the unique complexities of scRNAseq long-read datasets. Such tools are essential for the evaluation and optimization of isoform detection methods dedicated to single-cell long read studies.

Results
We developed AsaruSim, a workflow that simulates synthetic single-cell long-read Nanopore datasets, closely mimicking real experimental data. AsaruSim employs a multi-step process that includes the creation of a synthetic UMI count matrix, generation of perfect reads, optional PCR amplification, introduction of sequencing errors, and comprehensive quality control reporting. Applied to a dataset of human peripheral blood mononuclear cells (PBMCs), AsaruSim accurately reproduced experimental read characteristics.

Availability
The source code and full documentation are available at: https://github.com/GenomiqueENS/AsaruSim.

Supplementary information
Supplementary data are available at Bioinformatics online.
The Caring Encounters Guiding Framework: A Narrative Inquiry-Informed Innovative Model for Navigating Diversity
Authors: Braganza Morgan E , Hodge David R 
Published: February 2025

Abstract
Countries worldwide are characterised by increasing diversity. In Western societies, social diversification has contributed to escalating tension amongst people holding different worldviews. The emergence of what some have called superdiverse societies has led to calls for new models to assist social workers navigate differences. In response, the present study developed an innovative model—the Caring Encounters Guiding Framework—to successfully navigate difficult interactions. To develop this model, narrative inquiry was used with a sample of thirty-two individuals who self-identified as members of diverse groups. Analysis produced a preliminary Framework comprising three interconnected elements: Context, Core Issues and Prescriptions. The Framework provides guiding principles and processes for transversing interactions in both direct practice and educational settings. Included amongst these are considering the context in which interactions occur, attending to how differences are perceived and discussed, and using flexibility in approaching each interaction. Implementing the strategies embedded in this Framework positions social workers to interact with each individual in a caring and sensitive manner that respects their unique differences and cultural backgrounds.
A scoping review of birth alerts: A Canadian context
Authors: Elke Danielle , Choate Peter , Tortorelli Christina 
Published: February 2025

Abstract
This scoping review examines the history and application of birth alerts in Canada, from social work, legal, policy, and social justice lenses. In Canada, child welfare authorities developed a practice commonly known as birth alerts. This evolved across the country in an uneven fashion but has certainly been active since the early 2000s. There are many criticisms including causing undue trauma with children and families and disrupting early attachment as well as focus on Indigenous women in Canada as an example of racial bias (Doenmez et al. 2022). Since the release of the National Inquiry into Missing and Murdered Women and Girls (2019) report, provinces and territories have ended the practice. Literature reviewed examine birth alerts, pre-birth child welfare involvement and child welfare involvement at the birth of a child. Primarily, Canadian sources are used; however, countries with similar child welfare structures such as Australia, the UK, and the USA are considered. Studies using various methods have been included: qualitative, quantitative, mixed-method, systematic reviews, grey literature, and case law. This review uses the JBI Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methods for scoping reviews (Peters et al. 2015).
Association between amyloid-β42 levels and neuropsychiatric symptoms in Alzheimer’s disease trials
Authors: Abanto Jesus Thomas , Dwivedi Alok K , Imbimbo Bruno P , Espay Alberto J 
Published: February 2025

Abstract
Research on how Alzheimer’s disease drugs impact neuropsychiatric symptoms is limited. Given the link between changes in cerebrospinal fluid (CSF) amyloid-β42 (Aβ42) levels and cognitive and clinical outcomes after anti-Aβ treatments, we hypothesized a similar association exists with neuropsychiatric symptoms.
We conducted a meta-analysis of anti-Aβ drugs clinical trials to evaluate whether the changes in cerebrospinal Aβ42 levels are associated with neuropsychiatric symptoms, as measured by the Neuropsychiatric Inventory and if any such effect is mediated by changes in cognitive performance, as measured by the Mini-Mental State Examination.
Data from 10 trials involving 10,746 Alzheimer’s disease patients were included. Decreases in Aβ42 levels were associated with worsening Neuropsychiatric Inventory scores (Regression Coefficient [RC]: -0.68; 95% Confidence Interval [CI]: -1.07 to -0.29; P = 0.002), and this association persisted after adjusting for Mini-Mental State Examination. Sensitivity analyses confirmed the robustness of these findings.
Changes in CSF Aβ42 levels are inversely and independently associated with the frequency and severity of neuropsychiatric symptoms in anti-Aβ trials, suggesting a potential role of Aβ42 in modulating neuropsychiatric symptoms in Alzheimer’s disease.
Humoral and cellular immunogenicity of a fourth dose BNT162b2 in children with chronic kidney diseases
Authors: Chan Jeffery C H , Chan Eugene Yu-Hin , Cheng Samuel M S , Leung Daniel , Ho Fanny Tsz-Wai , Tong Pak-Chiu , Lai Wai-Ming , Lee Matthew H L , Chim Stella , Tsang Leo C H , Kwan Tsz-Chun , Cheuk Yin Celeste , Wang Manni , Wong Howard H W , Lee Amos M T , Li Wing Yan , Chan Sau Man , Tam Issan Y S , Lam Jennifer H Y , Zhang Kaiyue , Tu Wenwei , Peiris Malik , Duque Jaime S Rosa , Lau Yu Lung , Ma Alison Lap-Tak 
Published: February 2025

Abstract

Background
Children with chronic kidney diseases (CKD) are at risk of severe complications after SARS-CoV-2 infection and are recommended to receive vaccine boosters. Although COVID-19 boosters are effective in providing immune responses among healthy children, data on the use of a fourth dose among children with CKD are limited.

Methods
We prospectively investigated the immunogenicity and safety of a fourth dose of BNT162b2 in children with CKD. Dosages were 0.1 mL and 0.3 mL for children aged 5–11 years and 11–18 years, respectively. Humoral and cellular immunogenicity was assessed at pre-dose 4, and 1- and 6-month post-dose 4.

Results
Twenty-one children, with a median age of 14.0 years, were included for evaluation. A fourth dose of BNT162b2 elicited significant increases in humoral spike receptor-binding domain IgG levels and T-cell responses. Antibody responses were significantly lower among kidney transplant recipients or children receiving calcineurin inhibitors than other CKD children at 1-month post-dose 4. Breakthrough COVID-19 occurred in three children after the fourth dose, and one was hospitalized. One child developed mild gross hematuria 1 day after the fourth dose, which spontaneously resolved. The overall safety profile was acceptable.

Conclusions
A fourth dose of BNT162b2 was immunogenic and safe in children with CKD.