bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspectives of pharmacists and patients on pharmacist services to improve medication adherence among patients with diabetes in Indonesia
Authors: Presley Bobby , Groot Wim , Setiawan Eko , Pavlova Milena 
Published: April 2023

Abstract

Objectives
Pharmacists’ role in diabetes care is developing in improving medication adherence. Implementation of pharmacist services needs to consider patients’ and pharmacists’ perspectives as service users and providers, respectively. Therefore, this study investigates both perspectives on suitable pharmacist services to improve medication adherence in Indonesia.

Methods
This study used data collected based on open-ended survey questions, which were part of a survey among 917 patients and 99 pharmacists in community health centres (CHCs) and three hospitals in Surabaya, Indonesia. The open-ended questions aimed to elicit the perspective of patients and pharmacists on pharmacist services. The data were digitally recorded, transcribed and analysed in Atlas.ti 9th software using a pre-defined coding book. The data were then quantified.

Key findings
Most patients indicated they did not need services to improve medication adherence (67.25% CHCs vs. 63.06% hospitals). Those who did need services mostly preferred educational-based pharmacist services. This was also pharmacists’ most frequently mentioned service (45.45%). Consultation/counselling was the most common service to improve adherence according to pharmacists (66.67%) and patients (15.53% CHCs vs. 19.89% hospitals). Reminders about medication use and providing discussion sessions/seminars, and home care were other options mentioned. Limited human resources, time and pharmacists’ high workload were the most commonly identified barriers to implementing the desired pharmacist services.

Conclusion
Patients and pharmacists had similar perspectives on the desired services to improve medication adherence, especially educational-based services and consultation/counselling. Barriers to implementing services should be considered when evaluating the current practice and preparing for pharmacists’ future role in patient care.
Taming Pereboom’s Wild Coincidences
Authors: Müller Thomas 
Published: April 2023

AbstractPereboom’s ‘wild coincidences’ argument against agent-causal libertarianism is based on the claim that in a world governed by statistical laws, the dovetailing of indeterministic physical happenings with the free actions of agent causes would be a coincidence too wild to be credible. In this paper it is shown that the conclusion is valid for deterministic laws, but that it fails for statistical laws. Therefore, the ‘wild coincidences’ argument does not provide the promised empirical refutation of agent-causal libertarianism.
Thermodynamic properties of small flares in the quiet Sun observed by Hα and EUV: plasma motion of the chromosphere and time evolution of temperature/emission measure
Authors: Kotani Yuji , Ishii T T , Yamasaki D , Otsuji K , Ichimoto K , Asai A , Shibata K 
Published: April 2023

ABSTRACT
Small flares frequently occur in the quiet Sun. Previous studies have noted that they share many common characteristics with typical solar flares in active regions. However, their similarities and differences are not fully understood, especially their thermal properties. In this study, we performed imaging spectroscopic observations in the Hα line taken with the Solar Dynamics Doppler Imager on the Solar Magnetic Activity Research Telescope (SMART/SDDI) at the Hida Observatory and imaging observations with the Atmospheric Imaging Assembly onboard Solar Dynamics Observatory (SDO/AIA). We analysed 25 cases of small flares in the quiet Sun over the thermal energy range of $10^{24}{\!-\!}10^{27}\, \mathrm{erg}$ , paying particular attention to their thermal properties. Our main results are as follows: (1) We observe a redshift together with line centre brightening in the Hα line associated with more than half of the small flares. (2) We employ differential emission measure analysis using AIA multitemperature (channel) observations to obtain the emission measure and temperature of the small flares. The results are consistent with the Shibata & Yokoyama (1999, 2002) scaling law. From the scaling law, we estimated the coronal magnetic field strength of small flares to be 5–15 G. (3) The temporal evolution of the temperature and the density shows that the temperature peaks precede the density peaks in more than half of the events. These results suggest that chromospheric evaporations/condensations play an essential role in the thermal properties of some of the small flares in the quiet Sun, as does for large flares.
Multimass modelling of Milky Way globular clusters – I. Implications on their stellar initial mass function above 1 M⊙
Authors: Dickson N , Hénault-Brunet V , Baumgardt H , Gieles M , Smith P J 
Published: April 2023

ABSTRACT
The distribution of stars and stellar remnants (white dwarfs, neutron stars, and black holes) within globular clusters holds clues about their formation and long-term evolution, with important implications for their initial mass function (IMF) and the formation of black hole mergers. In this work, we present best-fitting multimass models for 37 Milky Way globular clusters, which were inferred from various data sets, including proper motions from Gaia EDR3 and HST, line-of-sight velocities from ground-based spectroscopy and deep stellar mass functions from HST. We use metallicity-dependent stellar evolution recipes to obtain present-day mass functions of stars and remnants from the IMF. By dynamically probing the present-day mass function of all objects in a cluster, including the mass distribution of remnants, these models allow us to explore in detail the stellar (initial) mass functions of a large sample of Milky Way GCs. We show that, while the low-mass mass function slopes are strongly dependent on the dynamical age of the clusters, the high-mass slope (α3; m &gt; 1 M⊙) is not, indicating that the mass function in this regime has generally been less affected by dynamical mass loss. Examination of this high-mass mass function slope suggests an IMF in this mass regime consistent with a Salpeter IMF is required to reproduce the observations. This high-mass IMF is incompatible with a top-heavy IMF, as has been proposed recently. Finally, based on multimass model fits to our sample of Milky Way GCs, no significant correlation is found between the high-mass IMF slope and cluster metallicity.
Stirred, not shaken: star cluster survival in the slingshot scenario
Authors: Matus Carrillo D R , Fellhauer M , Boekholt T C N , Stutz A , Morales Inostroza M C B 
Published: April 2023

ABSTRACT
We investigate the effects of an oscillating gas filament on the dynamics of its embedded stellar clusters. Motivated by recent observational constraints, we model the host gas filament as a cylindrically symmetrical potential, and the star cluster as a Plummer sphere. In the model, the motion of the filament will produce star ejections from the cluster, leaving star cluster remnants that can be classified into four categories: (a) filament-associated clusters, which retain most of their particles (stars) inside the cluster and inside the filament; (b) destroyed clusters, where almost no stars are left inside the filament, and there is no surviving bound cluster; (c) ejected clusters, that leave almost no particles in the filament, since the cluster leaves the gas filament; and (d) transition clusters, corresponding to those clusters that remain in the filament, but that lose a significant fraction of particles due to ejections induced by filament oscillation. Our numerical investigation predicts that the Orion Nebula cluster is in the process of being ejected, after which it will most likely disperse into the field. This scenario is consistent with observations which indicate that the Orion Nebula cluster is expanding, and somewhat displaced from the integral-shaped filament ridgeline.
Rotational state-changes in C5N− by collisions with He and H2
Authors: Biswas R , Giri K , González-Sánchez L , Gianturco F A , Lourderaj U , Sathyamurthy N , Veselinova A , Yurtsever E , Wester R 
Published: April 2023

ABSTRACT
The anion C5N− is one of the largest linear (C,N)-bearing chains detected in the interstellar medium. Here we present and discuss the general features of new ab initio potential energy surfaces describing the interaction of this linear anion with He and H2. We employ a Legendre Polynomials expansion representation for the former and an artificial neural network fit for the latter. We then carry out quantum scattering calculations to yield rotationally inelastic cross-sections for collisions with He and H2, using relative translational energy values in the range of 0.1–300 cm−1. We then obtained the corresponding inelastic rate coefficients as a function of temperature covering the range from 1 to 100 K. The results for these two systems are compared with each other, as well as with the earlier results on the C3N− colliding with the same partners. We found that the final inelastic rate coefficients for this anion are all fairly large, those from collisions with H2 being the largest. The consequences of such findings on their non-equilibrium rotational populations in interstellar environments are discussed in our conclusions.
Witnessing the intracluster medium assembly at the cosmic noon in JKCS 041
Authors: Andreon S , Romero C , Aussel H , Bhandarkar T , Devlin M , Dicker S , Ladjelate B , Lowe I , Mason B , Mroczkowski T , Raichoor A , Sarazin C , Trinchieri G 
Published: April 2023

ABSTRACT
In this work, we study the intracluster medium (ICM) of a galaxy cluster at the cosmic noon: JKCS 041 at z = 1.803. A 28 h long Sunyaev-Zel’dovich (SZ) observation using MUSTANG-2 allows us to detect JKCS 041, even if intrinsically extremely faint compared to other SZ-detected clusters. We found that the SZ peak is offset from the X-ray centre by about 220 kpc in the direction of the brightest cluster galaxy, which we interpret as due to the cluster being observed just after the first passage of a major merger. JKCS 041 has a low central pressure and a low Compton Y compared to local clusters selected by their ICM, likely because the cluster is still in the process of assembly but also in part because of a hard-to-quantify bias in current local ICM-selected samples. JKCS 041 has a 0.5 dex fainter Y signal than another less massive z ∼ 1.8 cluster, exemplifying how much different weak-lensing mass and SZ mass can be at high redshift. The observations we present provide us with the measurement of the most distant resolved pressure profile of a galaxy cluster. Comparison with a library of plausibly descendants shows that JKCS 041 pressure profile will likely increase by about 0.7 dex in the next 10 Gyr at all radii.
Heat shock transcription factors demonstrate a distinct mode of interaction with mitotic chromosomes
Authors: Price Rachel M , Budzyński Marek A , Shen Junzhou , Mitchell Jennifer E , Kwan James Z J , Teves Sheila S 
Published: April 2023

Abstract
A large number of transcription factors have been shown to bind and interact with mitotic chromosomes, which may promote the efficient reactivation of transcriptional programs following cell division. Although the DNA-binding domain (DBD) contributes strongly to TF behavior, the mitotic behaviors of TFs from the same DBD family may vary. To define the mechanisms governing TF behavior during mitosis in mouse embryonic stem cells, we examined two related TFs: Heat Shock Factor 1 and 2 (HSF1 and HSF2). We found that HSF2 maintains site-specific binding genome-wide during mitosis, whereas HSF1 binding is somewhat decreased. Surprisingly, live-cell imaging shows that both factors appear excluded from mitotic chromosomes to the same degree, and are similarly more dynamic in mitosis than in interphase. Exclusion from mitotic DNA is not due to extrinsic factors like nuclear import and export mechanisms. Rather, we found that the HSF DBDs can coat mitotic chromosomes, and that HSF2 DBD is able to establish site-specific binding. These data further confirm that site-specific binding and chromosome coating are independent properties, and that for some TFs, mitotic behavior is largely determined by the non-DBD regions.
UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease
Authors: Paisana Eunice , Cascão Rita , Custódia Carlos , Qin Nan , Picard Daniel , Pauck David , Carvalho Tânia , Ruivo Pedro , Barreto Clara , Doutel Delfim , Cabeçadas José , Roque Rafael , Pimentel José , Miguéns José , Remke Marc , Barata João T , Faria Claudia C 
Published: April 2023

Abstract

Background
Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies.

Methods
Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identified the upregulation of UBE2C, a gene that ensures the correct transition from metaphase to anaphase, across different primary tumor origins.

Results
Tissue microarray analysis of an independent BM patient cohort revealed that high expression of UBE2C was associated with decreased survival. UBE2C-driven orthotopic mouse models developed extensive leptomeningeal dissemination, likely due to increased migration and invasion. Early cancer treatment with dactolisib (dual PI3K/mTOR inhibitor) prevented the development of UBE2C-induced leptomeningeal metastases.

Conclusions
Our findings reveal UBE2C as a key player in the development of metastatic brain disease and highlight PI3K/mTOR inhibition as a promising anticancer therapy to prevent late-stage metastatic brain cancer.
Symmetry dictionary on charge and spin nonlinear responses for all magnetic point groups with nontrivial topological nature
Authors: Zhang Zhi-Fan , Zhu Zhen-Gang , Su Gang 
Published: April 2023

ABSTRACT
Recently, charge or spin nonlinear transport with nontrivial topological properties in crystal materials has attracted much attention. In this paper, we perform a comprehensive symmetry analysis for all 122 magnetic point groups (MPGs) and provide a useful dictionary for charge and spin nonlinear transport from the Berry curvature dipole, Berry connection polarizability and Drude term with nontrivial topological nature. The results are obtained by conducting a full symmetry investigation of the matrix representations of six nonlinear response tensors. We further identify every MPG that can accommodate two or three of the nonlinear tensors. The present work gives a solid theoretical basis for an overall understanding of the second-order nonlinear responses in realistic materials.
A multifunctional nanocomposite hydrogel with controllable release behavior enhances bone regeneration
Authors: Mao Yingji , Zhang Yiwen , Wang Ying , Zhou Tao , Ma Bingxu , Zhou Pinghui 
Published: April 2023

AbstractAutologous and allogeneic bone grafts remain the gold standard for repairing bone defects. However, donor shortages and postoperative infections contribute to unsatisfactory treatment outcomes. Tissue engineering technology that utilizes biologically active composites to accelerate the healing and reconstruction of segmental bone defects has led to new ideas for in situ bone repair. Multifunctional nanocomposite hydrogels were constructed by covalently binding silver (Ag+) core-embedded mesoporous silica nanoparticles (Ag@MSN) to bone morphogenetic protein-2 (BMP-2), which was encapsulated into silk fibroin methacryloyl (SilMA) and photo-crosslinked to form an Ag@MSN-BMP-2/SilMA hydrogel to preserve the biological activity of BMP-2 and slow its release. More importantly, multifunctional Ag+-containing nanocomposite hydrogels showed antibacterial properties. These hydrogels possessed synergistic osteogenic and antibacterial effects to promote bone defect repair. Ag@MSN-BMP-2/SilMA exhibited good biocompatibility in vitro and in vivo owing to its interconnected porosity and improved hydrophilicity. Furthermore, the multifunctional nanocomposite hydrogel showed controllable sustained-release activity that promoted bone regeneration in repairing rat skull defects by inducing osteogenic differentiation and neovascularization. Overall, Ag@MSN-BMP-2/SilMA hydrogels enrich bone regeneration strategies and show great potential for bone regeneration.
COMMERCIAL VOLTAGE INDICATOR AS A GAMMA RADIATION DETECTOR
Authors: Pejović Milić , Pejović Svetlana , Živanović Miloš 
Published: April 2023

Abstract
The paper analyses the possibility of commercial neon indicator lamp at low pressure application as a gamma radiation detector. The diode is most often used as an indicator in electrical switchers. The analysis was performed on the basis of experimental electrical breakdown time delay data as a function of relaxation time, applied voltage and gamma ray air kerma rate. It has been shown that the indicator can be used as a detector for relaxation time greater than 70 ms. During this time period, a complete recombination/de-excitation of the particles formed during previous breakdown and subsequent self-sustaining discharge, which can further initiate next breakdown, takes place. It was also shown that gamma radiation leads to a significant reduction in electrical breakdown time delay for applied voltages close to indicator breakdown voltage. Based on the behavior of the dependence of the mean value of the electrical breakdown time delay on the gamma ray air kerma rate, it was shown that the indicator can be used very efficiently as a detector up to air kerma rate of $\textsf{2.3}\cdot \textsf{10}^{-\textsf{5}}$ Gy/h, when the electrical breakdown time delay is measured for applied voltage 10% higher than the breakdown voltage.
Global trajectories of liver cancer burden from 1990 to 2019 and projection to 2035
Authors: Yang Fan , Sun Dianqin , Xia Changfa , Li He , Cao Maomao , Yan Xinxin , He Siyi , Zhang Shaoli , Chen Wanqing 
Published: April 2023

Abstract

Background:
Large disparities exist in liver cancer burden trends across countries but are poorly understood. We aimed to investigate the global trajectories of liver cancer burden, explore the driving forces, and predict future trends.

Methods:
Data on the liver cancer burden in 204 countries and territories from 1990 to 2019 were extracted from the Global Burden of Disease Study. The age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) trajectories were defined using growth mixture models. Five major risk factors contributing to changes in the ASIR or ASMR and socioeconomic determinants were explored using the identified trajectories. A Bayesian age-period-cohort model was used to predict future trends through 2035.

Results:
Three trajectories of liver cancer burden were identified: increasing, stable, and decreasing groups. Almost half of the American countries were classified in the decreasing group (48.6% for ASIR and ASMR), and the increasing group was the most common in the European region (ASIR, 49.1%; ASMR, 37.7%). In the decreasing group, the decrease of liver cancer due to hepatitis B contributed 63.4% and 60.4% of the total decreases in ASIR and ASMR, respectively. The increase of liver cancer due to alcohol use, hepatitis C, and hepatitis B contributed the most to the increase in the increasing group (30.8%, 31.1%, and 24.2% for ASIR; 33.7%, 30.2%, and 22.2% for ASMR, respectively). The increasing group was associated with a higher sociodemographic index, gross domestic product per capita, health expenditure per capita, and universal health coverage (all P <0.05). Significant variations in disease burden are predicted to continue through 2035, with a disproportionate burden in the decreasing group.

Conclusion:
Global disparities were observed in liver cancer burden trajectories. Hepatitis B, alcohol use, and hepatitis C were identified as driving forces in different regions.
Surgical Core Excision With Tongue Flap Closure in Combination With Electron Beam Radiotherapy in the Treatment of Ear Keloids
Authors: Ahmednaji Nebil Mahamoud , Wu Xiao-yan , Wang Yi-xiao , Chen Xiao-dong 
Published: April 2023

BACKGROUND
Ear keloids are disfiguring disorders resistant to various treatments.

OBJECTIVE
The authors aimed to assess the efficacy of surgical treatment of ear keloids in a Chinese population using a tongue flap with electron beam radiotherapy.

METHODS
The authors conducted a retrospective analysis of 41 patients treated at the Affiliated Hospital of Nantong University between January 2018 and May 2021. Core excision with a tongue flap was performed, followed by 3 days of electron beam radiotherapy and 3 to 6 months of pressure clip application. The Vancouver Scar Scale (VSS) and the Visual Analog Scale (VAS) were used to assess the results.

RESULTS
The mean age of the patients was 28.10 years (9–61 years). Postoperative follow-up ranged from 5 to 32 months (mean:12.07). The patients underwent 3 days of postoperative radiotherapy followed by pressure clips for 2 to 6 months. Thirty-seven patients had no recurrence, whereas 4 had a mild recurrence (<3 mm in height) with redness and itchiness. The VSS and VASscores significantly decreased. (p < .05)

CONCLUSION
Excision with a tongue flap and radiotherapy can be used as the primary treatment for ear keloids considering the good outcome and long-term management.
The Role of Extracellular Matrix in Wound Healing
Authors: Lin Pingping , Zhang Guohong , Li Hang 
Published: April 2023

BACKGROUND
Extracellular matrix communicates with surrounding cells to maintain skin homeostasis and modulate multiple cellular processes including wound healing.

OBJECTIVE
To elucidate the dynamic composition and potential roles of extracellular matrix in normal skin, wound healing process, and abnormal skin scarring.

MATERIALS AND METHODS
Literature review was performed to identify relevant publications pertaining to the extracellular matrix deposition in normal skin and wound healing process, as well as in abnormal scars.

RESULTS
A summary of the matrix components in normal skin is presented. Their primary roles in hemostasis, inflammation, proliferation, and remodeling phases of wound healing are briefly discussed. Identification of novel extracellular matrix in keloids is also provided.

CONCLUSION
Abnormal scarring remains a challenging condition with unmet satisfactory treatments. Illumination of extracellular matrix composition and functions in wound healing process will allow for the development of targeted therapies in the future.
Artificial sweeteners and cardiovascular risk
Authors: Gomez-Delgado Francisco , Torres-Peña Jose David , Gutierrez-Lara Gema , Romero-Cabrera Juan Luis , Perez-Martinez Pablo 
Published: April 2023

Purpose of review
Globalization and the increase in consumption of ultra-processed foods have led to a need for greater knowledge on the health impacts of certain nutrients such as artificial sweeteners. This review aims to analyse the role of artificial sweeteners (nutritive and nonnutritive) and their impact on cardiometabolic and cardiovascular disease (CVD) risk.

Recent findings
The detrimental effects of a high-calorie, high-sugar diet have been well established. In light of this, health authorities recommend limiting sugar consumption. This has led the food industry to develop different artificial sweeteners with specific properties, such as flavour and stability (nutritive artificial sweeteners: NAS), and others aimed at limiting sugar in the diet (nonnutritive artificial sweeteners: nNAS). Likewise, recent evidence explores the influence of artificial sweeteners (NAS and nNAS) on CVD risk through risk factors such as obesity and type 2 diabetes mellitus, among others.

Summary
This review aims to provide an updated overview of the impact of NAS and nNAS on cardiovascular health and provide recommendations regarding their consumption.