bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemispherectomy Outcome Prediction Scale: a validity study
Authors: Hale Andrew T. , Estevez-Ordonez Dagoberto , Badrani Jana , Sha Wen , Arynchyna-Smith Anastasia , Goyal Monisha , Mohamed Ismail , Kankirawatana Pongkiat , Rozzelle Curtis J. , Blount Jeffrey P. 
Published: July 2023

OBJECTIVE
Hemispherectomy is highly effective for patients with medically refractory epilepsy (MRE) arising from a single hemisphere. Recently, the Hemispherectomy Outcome Prediction Scale (HOPS) was developed as a prediction tool for seizure freedom after hemispherectomy. The authors’ goal was to perform a validation study to determine the generalizability of the HOPS score.

METHODS
The authors present an observational, retrospective, 20-year, single-institution, two-surgeon experience using the lateral peri-insular hemispherectomy approach to validate the HOPS score. Variables used to derive the HOPS score included seizure onset age, semiology, PET hypometabolism, seizure substrate, and history of prior epilepsy resection. Multivariable logistic regression, multiple imputation, and Bayesian analyses were used to determine validity.

RESULTS
The authors’ cohort comprised 60 patients; 55% of patients were male and 78% were Caucasian. The median age at first hemispherectomy surgery was 72 months. At 1 year postoperatively, 80% of patients had Engel class I outcomes, analogous to most contemporary series. All patients who experienced seizure recurrence after hemispherectomy did so within the first 2 years postoperatively. Sixteen (27%) and 10 (17%) patients had contralateral MRI findings and hypometabolism on PET, respectively. Both a multivariable logistic regression model using HOPS score variables (model p = 0.2588) and a revised model that included contralateral MRI findings (model p = 0.4715) were not statistically significant in this cohort. Bayesian analysis also did not validate the HOPS score.

CONCLUSIONS
While seizure outcome prediction tools may be helpful for counseling patients about postoperative outcomes, rigorous validity and reliability testing are required. Prospective, standardized, and longitudinal evaluation of patients undergoing hemispherectomy are needed.
A comparison of modern-era anterior lumbar interbody fusion and minimally invasive transforaminal lumbar interbody fusion at the lumbosacral junction
Authors: Farber S. Harrison , Dugan Robert K. , White Michael D. , Walker Corey T. , O’Neill Luke K. , Alan Nima , Zhou James J. , Turner Jay D. , Tumialán Luis M. , Uribe Juan S. 
Published: July 2023

OBJECTIVE
Interbody fusion is the primary method for achieving arthrodesis across the lumbosacral junction in the setting of degenerative pathologies, such as spondylosis and spondylolisthesis. Two common techniques are anterior lumbar interbody fusion (ALIF) and posterior transforaminal lumbar interbody fusion (TLIF). In recent years, interbody design and technology have advanced, and most earlier studies comparing ALIF and TLIF did not specifically assess the lumbosacral junction. This study compared changes in radiographic and clinical parameters between patients undergoing modern-era single-level ALIF and minimally invasive surgery (MIS) TLIF at L5–S1.

METHODS
Consecutive patients who underwent single-segment L5–S1 ALIF or MIS TLIF performed by the senior authors over a 6-year interval (January 1, 2016–November 30, 2021) were retrospectively reviewed. Upright radiographs were used to determine pre- and postoperative lumbar lordosis, segmental lordosis, disc angle, and neuroforaminal height. Improvements in patient-reported outcome scores (Oswestry Disability Index and SF-36) were also compared.

RESULTS
Overall, 108 patients (58 [54%] men, 50 [46%] women; mean [SD] age 57.6 [13.5] years) were included in the study. ALIF was performed in 49 patients, and TLIF was performed in 59 patients. The most common treatment indications were spondylolisthesis (50%, 54/108) and spondylosis (46%, 50/108). The cohorts did not differ in terms of intraoperative (p > 0.99) or postoperative (p = 0.73) complication rates. The mean (SD) hospital length of stay was significantly shorter for patients undergoing TLIF than ALIF (1.3 [0.6] days vs 2.0 [1.4] days, p < 0.001). Both techniques significantly improved L5–S1 segmental lordosis, disc angle, and neuroforaminal height (p ≤ 0.008). ALIF versus TLIF significantly increased mean [SD] segmental lordosis (12.5° [7.3°] vs 2.0° [5.7°], p < 0.001), disc angle (14.8° [5.5°] vs 3.0° [6.1°], p < 0.001), and neuroforaminal height (4.5 [4.6] mm vs 2.4 [3.0] mm, p = 0.008). Improvements in patient-reported outcome parameters and reoperation rates were similar between cohorts.

CONCLUSIONS
When treating patients at a single segment across the lumbosacral junction, ALIF resulted in significantly greater increases in segmental lordosis, L5–S1 disc angle, and neuroforaminal height compared with MIS TLIF. Improvements in clinical parameters and reoperation rates were similar between the 2 techniques.
Natural history of mild trigonocephalic deformities
Authors: Xu Summer , Leclair Nathan K. , Angelo Sophia , Paro Mitch , Stoltz Petronella , Anderson Megan , Martin Jonathan E. , Hersh David S. , Bookland Markus J. 
Published: July 2023

OBJECTIVE
Ridging along the metopic suture line can be a common cause of concern for parents and has been theorized to represent a mild form of trigonocephaly, a cranial deformity associated with risks of negative cosmetic outcomes, if not surgically corrected. Yet the literature contains sparse reports of long-term cosmetic results or expectations for infants with isolated metopic ridging compared with those with severe trigonocephaly, or even what objective metrics discriminate isolated metopic ridging from severe trigonocephaly. Therefore, the authors’ goals for this study were to 1) quantify the degree of frontal deformity among patients with metopic ridge, metopic craniosynostosis, and normocephalic head shapes; and 2) document the natural history of frontal deformities in isolated metopic ridge patients in the 1st year of life.

METHODS
This was a retrospective cohort study of patients with normocephalic head shapes, metopic ridges, and metopic craniosynostoses who presented at < 1 year of age to the Connecticut Children’s neurosurgery clinic from January 2019 to December 2021. Data were collected regarding demographics and photograph-based craniometrics.

RESULTS
A total of 212 normocephalic, 34 metopic ridge, and 29 metopic craniosynostosis patients were included. Both the normocephalic and metopic ridge groups had a significantly higher anterior arc angle (AAA) value compared with the metopic craniosynostosis group (p < 0.0001). The AAA did not differ significantly among normocephalic patients and those with ridging. Over the course of 1 year of follow-up, patients with metopic ridging demonstrated a slight decrease in AAA values, but overall remained within the same range as normocephalic patients.

CONCLUSIONS
Photograph-based craniometrics suggest that metopic ridge patients with frontal bone angulations > 2.2 radians have a mild degree of frontal constriction that does not significantly worsen over the 1st year of life.
Pengaruh Return On Asset dan Debt To Total Asset Terhadap Pertumbuhan Laba Pada PT Unilever Indonesia Tbk
Authors: Erwin Aji , Prasetyo Hendri , Yanuarti Maghfiroh 
Published: July 2023

Tujuan pada riset ini ialah untuk mengetahui apakah ada pengaruh antara ROA (return on assets) dan DAR (Dept to total asset) terhadap Pertumbuhan laba pada PT. Unilever Indonesia Tbk tahun 2010 – 2019 secara parsial dan simultan. Metode penelitian pada riset ini ialah metode kuantitatif dengan menggunakan perhitungan yang dimulai dengan uji susmsi klasik, analisis regresi linear, analisis koefisien korelasi, koefisien determinasi, dan uji hipotesis. Hasil riset ini menunjukkan bahwa (1) terdapat pengaruh ROA terhadap pertumbuhan laba yang ditunjukkan oleh nilai t hitung > t table yaitu 2,679 > 2,365; (2) Tidak terdapat pengaruh DAR terhadap perttumbuhan laba yang ditunjuukan oleh nilai t hitung < t table yaitu -0,768 < 2,365; dan (3) Terdapat pengaruh ROA dan DAR terhadap pertumbuhan laba yang ditunjuukan oleh nilai f hitung > f table yaitu 6,809 > 4,46. The purpose of this research is to find out whether there is an influence between ROA (return on assets) and DAR (Dept. to total assets) on profit growth at PT. Unilever Indonesia Tbk 2010 – 2019 partially and simultaneously. The research method in this research is a quantitative method using calculations that begin with the classical assumption test, linear regression analysis, correlation coefficient analysis, coefficient of determination, and hypothesis testing. The results of this research indicate that (1) there is an effect of ROA on profit growth as indicated by the t count > t table, namely 2.679 > 2.365; (2) There is no effect of DAR on profit growth as indicated by the value of t count < t table, namely -0.768 < 2.365; and (3) there is an effect of ROA and DAR on profit growth as shown by the value of f count > f table, namely 6.809 > 4.46.
ПРОБЛЕМИ КРИМІНАЛЬНОЇ ВІДПОВІДАЛЬНОСТІ ЗА НЕЗАКОННЕ ПЕРЕМІЩЕННЯ ОСІБ В КОНТЕКСТІ ЗБРОЙНОГО КОНФЛІКТУ: НАУКОВИЙ АНАЛІЗ ЗАКОНОДАВЧИХ ІНІЦІАТИВ
Authors: ЛИТВИНОВ О.М. , ОРЛОВ Ю.В. , ЯЩЕНКО А.М. 
Published: July 2023

Стаття присвячена науковому аналізу законопроєктів, якими пропонується внесення змін та доповнень до Кримінального кодексу України з питань кримінальної відповідальності за незаконне (насильницьке) переміщення осіб в умовах збройного конфлікту в Україні. З урахуванням положень міжнародного кримінального, гуманітарного права, практики діяльності міжнародних судів ad hoc, а також вітчизняної доктрини кримінального права здійснено висновки, висловлено критичні судження щодо окремих положень законопроєктів, сформовано авторські пропозиції у виді альтернативних проєктів законів про кримінальну відповідальність.
ДО ПИТАННЯ ПРО НЕОБХІДНІСТЬ ВНЕСЕННЯ ЗМІН ДО КРИМІНАЛЬНОГО ЗАКОНОДАВСТВА УКРАЇНИ В УМОВАХ ДІЇ ПРАВОВОГО РЕЖИМУ ВОЄННОГО СТАНУ
Authors: Шевчук Т.А. 
Published: July 2023

Розглянуто зміни у кримінальному законодавстві України у зв’язку із введенням на її території режиму воєнного стану. Визначено основні вектори змін та доповнень до Кримінального кодексу України, зокрема це стосується таких діянь: колабораційна діяльність; пособництво державі- агресору; несанкціоноване поширення інформації про направлення, переміщення зброї, озброєння та бойових припасів в Україну, рух, переміщення або розміщення Збройних Сил України; незаконне використання з метою отримання прибутку гуманітарної допомоги, благодійних пожертв або безоплатної допомоги та ін.
Окреслено основні проблеми застосування кримінального законодавства України у зв’язку із змінами, які були внесені до Кримінального кодексу України після 24 лютого 2022 року.
Акцентовано увагу на необхідності дотримання основних принципів законодавчої техніки та недопущення розбалансування системи всього кримінального законодавства України.
ВИДИ КРИМІНАЛЬНОГО РАДИКАЛІЗМУ: КРИМІНОЛОГО- ЕКЗИСТЕНЦІАЛЬНИЙ ПІДХІД
Authors: ДАНИЛЬЧЕНКО П.Ю. 
Published: July 2023

Стаття присвячена розкриттю кримінолого-екзтистенціального підходу до видової диференціації кримінального радикалізму. Встановлено, що останній є вельми різнобічним. Лише зовнішні його прояви характеризуються операційною, атрибутивною (за ознаками складів кримінальних правопорушень) одноманітністю. Внутрішні ж, психологічні, екзистенціальні грані кримінального радикалізму є варіативними. Проведене дослідження дозволило виділити 8 його видів: самоактуалізаційний, мегалотимний, ізотимний, солідаризаційний, танатофобний, ресентиментарний, свободо-центруючий та свободо-елімінуючий. Надано їх характеристику.
La Asociación de Autoeficacia y satisfacción con los estudios en estudiantes universitarios
Authors: Riveros Paredes Pamela Norma 
Published: July 2023

La autoeficacia académica (AA) es importante en la regulación de la estructura humana e influye en el desempeño académico (Bandura et al., 1999); así también la satisfacción con los estudios (SE) repercute en el empeño del alumno en lo que compete al éxito en su carrera, así como en su permanencia en la universidad (Gür Erdoğan & Arsal, 2015), también se ha identificado a la AA como predictor de la SE (DeWitz & Walsh, 2002). El presente es un estudio correlacional que está conformado por 200 jóvenes de edades comprendidas entre 17 y 36 años, 88 varones y 112 mujeres. Para la recolección de datos se utilizó la Adaptación de la Escala de Autoeficacia Percibida Específica en Situaciones Académicas (Dominguez Lara et al., 2012) y la Escala Breve de Satisfacción con los estudios (Merino-Soto et al., 2017). Los resultados señalan que existe una relación estadísticamente significativa entre la autoeficacia y satisfacción con los estudios (p < 0.001); además su correlación es alta (rho = 0.527); por otro lado, las mujeres presentaron mayor puntaje en la satisfacción con los estudios que los varones; en cuanto a la AA no se encontraron diferencias significativas.
Aplicación de la técnica PASER para reprocesar pensamientos traumáticos: Dos diseños de sujeto único de reversión
Authors: Piñeyro Diego , Azzollini Susana Celeste , Squillace Louhau Mario , Marquina Lujan Roman Jesús 
Published: July 2023

Diversas técnicas cognitivo-conductuales buscan reestructurar pensamientos que intrusivamente irrumpen en el foco atencional de sujetos que padecen problemas de estrés y ansiedad. Las técnicas de reestructuración cognitiva de Beck, la desensibilización sistemática de Wolpe, el uso de EMDR de Shapiro y las más recientes intervenciones de imagery rescripting, han mostrado diversos grados de eficacia, cada una abordando el problema con intervenciones propuestas desde las limitaciones del propio marco teórico. El presente estudio se basa en la aplicación de la técnica PASER (Procesamiento Asistido de Situaciones Estresantes Recientes) la cual integra intervenciones de los tratamientos mencionados de una forma novedosa y en tiempos muy breves. Dos sujetos adultos con Trastorno de Dependencia de la Personalidad fueron tratados individualmente en tres sesiones de PASER para reprocesar escenas altamente estresantes. Se evaluó el grado de perturbación emocional con el Inventario APPEM en seis fases de un diseño de sujeto único de reversión (ABABAB). Se complementó el estudio con una entrevista en profundidad. Se observó una reducción muy notoria de los niveles de perturbación emocional, reactividad ansiosa predominantemente cognitiva y fisiológica en uno de los casos y resultados modestos en el otro. Se requieren nuevas investigaciones para comprender los diferentes grados de eficacia.
Studi Deskriptif Pesan Dakwah tentang Kesehatan Pada Konten Kreator Youtube dr. Zaidul Akbar
Authors: Hasanah Nur , Ravico Ravico , Firtanosa Aan 
Published: July 2023

dr. Zaidul Akbar was used YouTube as a media for da'wah by the health themes, YouTube is very good way to use for da’wah, because it presents interesting content. Then, da'wah messages with health themes will be easily accepted and understood. This research wanted to know about da'wah messages with health themes in videos that last 40:34 and 50:31 minutes durations which are uploaded on dr. Zaidul Akbar content. This reaserch was used a qualitative approach, and intsrument was used observation by the sense of sight, which means not asking questions, in other words, the researcher wanted to observe directly on Dr. Zaidul Akbar's YouTube content. After conducting the research, the researcher found that the results of da'wah messages about health in dr. Zaidul Akbar content, consists of 5 moral messages, 4 sharia messages, and 1 aqidah message. In both videos that are 40:34 and 50:31 minutes durations. Da'wah messages about health that are often discussed in their content are moral messages with a total of 5 discussions of moral messages. The health messages include explanations regarding the benefits of dates, spices such as ginger, turmeric, galangal, and lemongrass. dr. Zaidul Akbar also explained the benefits of almsgiving, prayer, fasting, doing good to others for physical, mental and other social health
Activity of tafasitamab in combination with rituximab in subtypes of aggressive lymphoma
Authors: Patra-Kneuer Maria , Chang Gaomei , Xu Wendan , Augsberger Christian , Grau Michael , Zapukhlyak Myroslav , Ilieva Kristina , Landgraf Karin , Mangelberger-Eberl Doris , Yousefi Kasra , Berning Philipp , Kurz Katrin S. , Ott German , Klener Pavel , Khandanpour Cyrus , Horna Pedro , Schanzer Jürgen , Steidl Stefan , Endell Jan , Heitmüller Christina , Lenz Georg 
Published: July 2023

BackgroundDespite recent advances in the treatment of aggressive lymphomas, a significant fraction of patients still succumbs to their disease. Thus, novel therapies are urgently needed. As the anti-CD20 antibody rituximab and the CD19-targeting antibody tafasitamab share distinct modes of actions, we investigated if dual-targeting of aggressive lymphoma B-cells by combining rituximab and tafasitamab might increase cytotoxic effects.MethodsAntibody single and combination efficacy was determined investigating different modes of action including direct cytotoxicity, antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) in in vitro and in vivo models of aggressive B-cell lymphoma comprising diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).ResultsThree different sensitivity profiles to antibody monotherapy or combination treatment were observed in in vitro models: while 1/11 cell lines was primarily sensitive to tafasitamab and 2/11 to rituximab, the combination resulted in enhanced cell death in 8/11 cell lines in at least one mode of action. Treatment with either antibody or the combination resulted in decreased expression of the oncogenic transcription factor MYC and inhibition of AKT signaling, which mirrored the cell line-specific sensitivities to direct cytotoxicity. At last, the combination resulted in a synergistic survival benefit in a PBMC-humanized Ramos NOD/SCID mouse model.ConclusionThis study demonstrates that the combination of tafasitamab and rituximab improves efficacy compared to single-agent treatments in models of aggressive B-cell lymphoma in vitro and in vivo.
Biological age markers in solid-phase structures of the oral fluid
Authors: Shabalin V.N. , Shatokhina I.S. , Shatokhina S.N. 
Published: July 2023

Markers of aging known today do not clearly define the biological age of the organism, which creates the need for their further search. The oral fluid is a convenient object for such studies, since it contains proteins whose conformation corresponds to the age of the organism. The method developed by the authors allows, by transferring biological fluids into a solid phase, to transform the structure of the molecular-level components dissolved in them to a level accessible to visual analysis.
The aim of the study is to search for markers of biological age in the solid-phase structures of the oral fluid.
Materials and methods. The structures of the solid phase oral fluid of 240 people with a sanitized oral cavity were studied. There are four age groups of 60 patients each: middle age; elderly; senile and long-livers. Oral fluid was taken in the morning on an empty stomach. The method of cuneiform dehydration of biological fluids was used. Dehydration of drops of oral fluid was carried out on special test cards under standard conditions. As a result, dry films (facies) were obtained, the structural features of which were examined by microscopy.
Results. The structure of oral fluid facies is determined by the ratio of salt and organic substances present in it. During the formation of a facies, salts bind to proteins that have an abnormal conformation. In middle-aged patients, the facies have a clear division into saline and marginal (protein) zones. With age (elderly and senile age), due to the increased activity of catabolic processes, in the facies of the oral fluid, an increasing area is occupied by organic substances, and the areas occupied by salts decrease, while the facies lose their physiological structuring. At the same time, the facies of the oral fluid of most long-livers retain a structure similar to the facies of middle-aged representatives.
Conclusions. The biological age of the organism is determined by the level of its autointoxication by proteins with pathological conformation. Autotoxins are contained in the oral fluid and are manifested in the structure of its facies. Due to natural age-related metabolic shifts towards an increase in catabolic processes, the protective systems that block autointoxication by metabolites cease to provide their complete neutralization, which is reflected in the facies structure. Facies of the oral fluid of long-livers have a fundamentally different structure compared with the facies of the elderly and senile persons, indicating a low degree of autointoxication of the organism of long-livers, which determines a longer life span. Thus, specific solid phase structures of oral fluid facies can be used as objective markers of biological age.
An Analysis of Code-Mixing in The Novel "Tentang Kamu" by Tere Liye
Authors: Raflis Raflis , Mouren Dian Agustin Mouren 
Published: July 2023

This thesis deal with the types of Code Mixing found in Tere Liye’s Novel ”Tentang Kamu”. The thesis is focused on analyzing the code mixing used in the text within the novel. The main purpose of this thesis is to find out the types of Code Mixing in Tere Liye’s Novel ”Tentang Kamu”, to find out the most used type of the Code Mixing and to analyze the reasons and functionality of the particular Code Mixing used. The data of this study is 167 clauses containing code mixing that found in in Tere Liye’s Novel ”Tentang Kamu”. This research was conducted by using Descriptive Qualitative Research. The technique used to collect the data was documentary technique reading, studying, and analyzing all the data. The data were analyzed by using Hoffman theory of Code Mixing. Based on the data analysis, it was found that there were three types of Code Switching found in Tere Liye’s Novel ”Tentang Kamu” which is Intra-sentential Code Mixing, Intra-sentential Code Mixing and Involving Change of Pronunciation Code Mixing. Furthermore, There are seven functions Code Mixing that is found within the text in Tere Liye’s Novel ”Tentang Kamu”, which is Talking About Particular Topic, Quoting Somebody Else, Being Emphatic about Something, Interjection, Repetition Used for Clarification, Intention of Clarifying the Speech Content for Interlocutor, and Expressing Group Identity. The most dominant types of Code Mixing used in Tere Liye’s Novel ”Tentang Kamu” was Intra-sentential Switching with 134 clauses out of 167 clauses found in the text (80,2%). Furthermore, the most dominant functions of Code Mixing that is found within the text in Tere Liye’s Novel ”Tentang Kamu”, which is Talking About Particular Topic (126 clauses out of 167 clauses, 75,4%).
Restorative Justice Sebagai Alternatif Pengurangan Over Kapasitas Di Rutan Kelas I Jakarta Pusat
Authors: Theosalim Alicia Salsabila , Hutabarat Rugun Romaida 
Published: July 2023

Sejalan dengan perkembangan zaman yang begitu cepat, kesenjangan ekonomi semakin tinggi sehingga hal tersebut menyebabkan kriminalitas yang sangat tinggi di Indonesia yang berampak pada tingkat overkapasitas yang tinggi di RUTAN dan LAPAS seluruh Indonesia. Maka dari itu Indonesia perlu sebuah penyelesaian perkara tindak pidana ringan yang tidak hanya fokus pada pidana pemenjaraan yang pada akhirnya hanya menyebabkan overkapasitas di RUTAN dan LAPAS dan menyebabkan tidak efektifnya fungsi dari Lembaga permasyarakatan. Restorative Justice merupakan sebuah alternatif penyelesaian perkara tindak pidana ringan yang lebih mementingkan keadilan hak-hak para pihak yang terlibat tanpa melalui litigasi sehingga perkara dapat diselesaikan dengan mediasi antara korban, pelaku dan pihak terkait sehingga tercapainya perdamaian dan hak korban dapat terjamin. Dalam implemetasi keadilan restoratif salah satunya yang dilakukan oleh Jaksa dalam penghentian penuntutan.