bluuebunny/crossref_metadata_2025_split huggingface dataset:
What drives the public's use of data? The mediating role of trust in science and data literacy in functional scientific reasoning concerning COVID‐19
Authors: Tabak Iris , Dubovi Ilana 
Published: March 2023

AbstractIs public engagement with science deliberative and evidence‐based? The public is often perceived as underprepared to use data and susceptible to partisan and emotional manipulation. Consequently, educational efforts focus on the ability to identify reliable information. We posit that effective engagement with science goes beyond this and hinges on data literacy. We leveraged the unique circumstances of COVID‐19, where diverse people inundated with pandemic‐related data representations in the media needed to make consequential decisions, to examine whether people use data and what factors affect such use. In a survey of a representative Israeli adult sample, participants reported their information habits and beliefs before and during COVID‐19. On being presented with graphs and datasets, they answered data literacy and COVID‐19‐related functional reasoning assessments (e.g., would you travel abroad?). Data literacy distinguished those who incorporated data from those who did not. Yet, participants incorporated moral, social, and economic considerations at all data literacy levels, suggesting that people may be deliberative even when they do not attend to quantified data. Moreover, participants' trust in science and data interpretation competence were key factors mediating the relationship between self‐efficacy in data interpretation skills and the incorporation of data in reasoning. The findings extend beyond COVID‐19 to a broader understanding of the factors influencing public engagement with quantitative representations. Rather than focusing solely on remediating data interpretation, we suggest that educative efforts work on multiple fronts and that cultivating trust in science is key to a broader, more deliberative engagement with science.
Electrocatalytic Multicomponent Transformation of Aldehyde, 5‐Amino‐3‐methyl‐1‐phenylpyrazole and Dimedone: An Efficient Protocol for Substituted Pyrazolo[3,4‐b]quinolines
Authors: Qian Cunwei , Wang Ying , Li Xian , Yao Changsheng 
Published: March 2023

AbstractA convenient, rapid and electrochemical one‐pot protocol was developed successfully for the preparation of pyrazolo[3,4‐b]‐quinoline derivatives. The reaction is carried out in a 25 mL three neck flask equipped with graphite electrode as anode and iron electrode as cathode (electrode area of 1 cm2) with sodium bromide as supporting electrolyte at room temperature in ethanol. Fourteen pyrazolo‐[3,4‐b]‐quinoline derivatives were synthesized by use of various aldehyde (including aryl aldehydes and aliphatic aldehydes), dimedone and 5‐amino‐3‐methyl‐1‐phenylpyrazole as substrates in good yields (76–86 %) with a constant current of 30 mA after 0.14 F/mol of electricity passed. All aimed products were characterized by IR, 1H NMR and HRMS. Notably, the presented method features ecologically sound, simple experimental procedure and good yields.
Controlled 5‐FU Release from P(NIPAM‐co‐VIm)‐g‐PEG Dual Responsive Hydrogels
Authors: Güngör Ahmet , Özdemir Tonguç , Genç Rükan 
Published: March 2023

Abstract5‐fluorouracil (5‐FU) forms the basis of many chemotherapy regimens and is one of the most widely used chemotherapeutic drugs in the treatment of solid malignancies. In this study, (i) Poly N‐isopropyl acrylamide (PNIPAM) synthesized by free radical polymerization method, (ii) temperature and pH responsive P(NIPAM‐co‐VIm) synthesized by copolymerization of N‐isopropyl acrylamide (NIPAM) with 1‐vinyl imidazole (VIm) and (iii) the 5‐FU release of P(NIPAM‐co‐VIm)‐g‐PEG prepared by grafting with polyethylene glycol (PEG). In the temperature and pH sensitivity analyzes revelaed that the LCST value increased as a result of the treatment of PNIPAM with VIm and PEG, on the other hand the hydrogel in the swollen phase in the acidic environment, the hydrogel turned into a precipitated form as the environment became alkaline. To investigate the utilize of hydrogels, release mediums of two different pHs (pH 5.5 and 7.4) and two different temperatures (25 °C and 37 °C) were applied. The cumulative release results showed that the release ratio of 5‐FU was 95 % when the release medium pH was 7.4 and ambient temperature 37 °C. Consequently, P(NIPAM‐co‐VIm)‐g‐PEG hydrogels at different pH and temperature mediums could be beneficially utilized as an material with a potential to be used in targeted drug delivery systems.
Surprising Tribo‐catalytic Conversion of H2O and CO2 into Flammable Gases utilizing Frictions of Copper in Water
Authors: Cui Xiaodong , Wang Hongbo , Lei Hua , Jia Xuchao , Jiang Ying , Fei Linfeng , Jia Yanmin , Chen Wanping 
Published: March 2023

AbstractCopper rotary disks were fabricated through mounting copper disks and magnets on opposite surfaces of Teflon disks separately, and quartz glass reactors (150 mL) were modified through covering their bottoms with Al2O3, copper, and titanium disks separately. For a glass‐bottomed reactor placed with a copper rotary disk and filled with 50 mL water and 1 atm CO2, flammable gases of 670.96 ppm H2, 22.21 ppm CO, 3.98 ppm CH4, 0.96 ppm C2H4, and 0.66 ppm C2H6 were surprisingly produced after the copper rotary disk was driven to rotate for 5 h; flammable gases were obtained in comparable amounts for reactors with Al2O3, copper, and titanium bottoms separately. A tribo‐catalytic mechanism has been proposed, in which water at micro‐holes in friction surfaces is squeezed by elastically deformed copper of rotating copper disks, and under increased pressure CO2 and H2O are catalyzed to react to form flammable gases by copper.
Simultaneous Determination of Ranitidine and Metronidazole at Low Potential Using an Acid‐Activated Glassy Carbon Electrode
Authors: Karim Rejwana , Saha Protity , Akter Riva , Falguni Rokaiya , Shital Regoana Amin , Awal Abdul , Al Mamun Mohammad , Ahammad A. J. Saleh 
Published: March 2023

AbstractA simple, highly sensitive and inexpensive electrochemical method was established using an activated glassy carbon electrode (AGCE) in an acidic condition for the determination of ranitidine (RT) and metronidazole (MT) simultaneously at a low potential range. The AGCE was characterized using various techniques such as electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and morphology was studied through field‐emission scanning electron microscope (FE‐SEM). The AGCE exhibited an electrocatalytic behavior towards the reduction of RT and MT in 0.5 M acidic solution. Both CV and DPV responses for the mixture of RT and MT gave well‐resolved peaks at low potential. Analysis of these experiments helps us to predict interactions that took place on the surface of AGCE and RT and MT with each other for having different types of functional groups. Furthermore, AGCE also promoted the electron transfer process. The linear dynamic range of MT and RT was 0.5–580 μM and 0.5–500 μM, respectively with the regression coefficient 0.99. The detection limit (S/N=3) calculated for MT and RT was 0.062 μM and 0.13 μM, respectively. Decent results were obtained from the reproducibility and stability test. The performance of the sensor was evaluated for the possible interferences which show high selectivity. Additionally, the real sample analysis was carried out to understand our sensor‘s applicability in real life.
Morphological Regulation Mechanism of Tubular Ferrous Oxalate: Theoretical and Experimental Study
Authors: Xu Peilin , Chen Xiumin , Wu Jian , Liu Li , Yin Qi , Liu Bo , Yang Lianfeng , Zhao Xiran , Xu Baoqiang , Jiang Wenlong , Liu Dachun , Yang Bin 
Published: March 2023

AbstractThe formation mechanism and morphology regulation mechanism of tubular ferrous oxalate were investigated by density functional theory. The calculation results showed that the pH value of the reaction solution changed from slightly alkaline to acidic was an important condition for the formation of tubular ferrous oxalate. The size and dispersion of ferrous oxalate can be controlled by introducing Na+ and ethylene glycol (EG) into the reaction system. Guided by theoretical calculations, using sodium oxalate as material to guarantee the initial solution to be slightly basic, while also introducing Na+. Regular tubular ferrous oxalate was successfully obtained by using different ratios of EG and H2O as reaction solution and adjusting pH values at different stages, verified the rationality of the theoretical calculation results. The tubular ferric oxide was obtained by thermal decomposition using tubular ferrous oxalate as the precursor, and the electrochemical performance test results showed that this material is a potential electrode material for supercapacitors.
A Promising HKUST‐1@SiO2 Composite for the Effective Adsorption of Chlorpyriphos from Aqueous Medium
Authors: Sharma Prachi , Jatrana Anushree , Mondal Sanchit , Maan Sheetal , Kumar Vinay 
Published: March 2023

AbstractThis study focuses on the preparation of HKUST‐1@SiO2 composite and its application as an adsorbent for the removal of chlorpyriphos from water environment. For studying the physical properties, synthesized HKUST‐1@SiO2 was characterized using FTIR, XRD, BET, FE‐SEM and EDS. Characterization results indicated that the interaction of HKUST‐1 with SiO2 resulted in improvement of various physicochemical properties. The integration of HKUST‐1 and SiO2 resulted in improved adsorption of chlorpyrifos, where maximum 85 % removal was obtained at 30 °C. The adsorption data was best fitted into Langmuir isotherms, and it was in well accordance with pseudo second order kinetic model. High adsorption efficiency of the composite is related to its high pore volume which results in high number of adsorption sites on silica surface for the attachment of various functional groups present in chlorpyriphos.
Design, Synthesis and Anticancer Activity of New Benzofuran‐Chalcone Hybrids and Their Water Soluble Sodium Salts
Authors: Cinar‐Asa Sibel , Coskun Demet , Akgun Oguzhan , Akgun Halime , Fatih Coskun Mehmet , Ari Ferda 
Published: March 2023

AbstractIn this study, firstly, 1‐(7‐ethoxy‐1‐benzofuran‐2‐yl) ethanone and 1,1’‐(7‐ethoxy‐1‐benzofuran‐2,4‐diyl)diethanone were synthesized for the starting reagent purposes. The synthesized benzofuran‐chalcone salts were soluble in water at room temperature. Structural analysis of the synthesized compounds was characterized by elemental analysis, FT‐IR and NMR spectroscopy techniques. The anticancer activities of the compounds were determined by SRB viability assay in human lung cancer (A549, H1299) and breast cancer (MCF‐7, MDA‐MB‐231) cell lines. Findings for apoptosis were determined by flow cytometry analysis and the PARP‐ELISA method. The results of the in vitro SRB analysis of the compounds showed that some of the chalcone hybrids were very effective on both types of cancer in a dose and time‐dependent manner. Treatment of all cancer cell types with these hybrids resulted in a significant increase in the percentage of early and mainly late apoptotic cells, demonstrating their apoptosis‐inducing effects via the Caspase 3/7 Activity.
Green One‐Pot Chemo‐Enzymatic Synthesis of a Key Chiral Amine Intermediate: Useful to Pralsetinib Synthesis
Authors: Rajendra Gaikwad , Ganesh Krithika , Rajulu G Govinda , Sambasivam Ganesh , Selvaraj Ramaraj , Kumar G Charan , Ravikumar Shashank C , Acharya Prajwal C , Shivashankarappa Nagashree 
Published: March 2023

AbstractA facile, chemo‐enzymatic one‐pot and scalable procedure was developed for the synthesis of the key chiral intermediate of pralsetinib in an aqueous micellar medium. This method afforded the desired chiral intermediate with high enantioselectivity without the use of any expensive chiral ligands and toxic reagents that are difficult to handle. A green synthesis of chiral intermediate of pralsetinib was carried out using an enzyme ATA‐260 in an aqueous media with >99.9 % ee that was confirmed by a chiral reverse‐ phase HPLC. This study hence represents a mild and scalable procedure for the synthesis of the chiral intermediate of Pralsetinib with yields exceeding 80 %, which forms a crucial step in the synthesis of the anti‐ cancer drug.
1,3‐Benzodioxole Tagged Lidocaine Based Ionic Liquids as Anticancer Drug: Synthesis, Characterization and In Silico Study
Authors: Sangeeta  , Sonaxi  , Tomar Ravi , Agrawal Swati , Sarkar Anjana 
Published: March 2023

AbstractSkin cancer is by far the most frequent type of cancer in humans which gradually increases day by day. Numerous treatments are traditionally and conventionally available in the market but due to various factors such as high dose, high cost, adverse side effects, and so on. So, these treatments require novel routes of action and target drugs that can overcome these drawbacks. As per the ritual of our research group to design a new drug for mankind, we have synthesized derivatives of 1,3‐Benzodioxole tagged lidocaine‐based ionic liquid in the present work and characterized using techniques like 1H, 13C NMR, and infrared spectroscopy. The in‐silico studies were conducted which provided information regarding the binding mode of active 1,3‐benzodioxole‐derived ILs with the tubulin protein (1TUB) receptor. The binding affinity for [Pip‐Lid]OAc and [Pip‐Lid]OTf are −384.47 kJ/mol and −355.74 kJ/mol respectively. The properties of these ionic liquids like ADMET, blood‐brain barrier permeability, and drug‐likeliness proved the potency of the given compound for the treatment of skin cancer. Briefly, the current study showed the good anticancer potential of synthesized ionic liquids against skin cancer.
Metal‐Free Synthesis via Intramolecular Cyclization, Enzyme Inhibition Properties and Molecular Docking of Novel Isoindolinones
Authors: Atmaca Ufuk , Saglamtas Ruya , Sert Yusuf , Çelik Murat , Gülçin İlhami 
Published: March 2023

AbstractHighly effective one‐pot synthesis of novel isoindolinones from various 2‐benzoylbenzoic acid derivatives with intramolecular cyclization in the presence of chlorosulfonyl isocyanate was reported in mild conditions in the absence a metal catalyst. Novel synthesized compounds were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐glycosidase and carbonic anhydrase I and II (hCA I and hCA II) enzymes that associated with Alzheimer's disease (AD), type‐2 diabetes mellitus (T2DM), epilepsy, and glaucoma. A series of novel isoindolinones (2 a–l) were evaluated as highly potent inhibition ability toward AChE (Kis: 2.33–13.81 μM), BChE (Kis: 1.45–12.27 μM), α‐glycosidase (Kis: 8.03–23.05 μM), hCA I (Kis: 2.23–17.35 μM) and hCA II (Kis: 2.86–18.13 μM). Also, for these inhibitors, in silico molecular docking simulations and calculations were done with the Autodock Vina program to support the in vitro experimental studies.
Synthesis and Characterization of API‐Related Substances in Abiraterone Acetate**
Authors: Sasikala Ch. V. A. , Namshamgari Srikanth , Bandreddi Veeranjaneyulu , Nahide Pradip D. , Kiran Kumar C. , Kumar Roy Amrendra , Vakamulla Malati , Kumar Madhra Mukesh , Annapragada Ratnamala , Bandichhor Rakeshwar 
Published: March 2023

AbstractAbiraterone acetate (Zytiga®) is known as an anticancer medication that inhibits an enzyme called cytochrome P450 (CYP17) responsible for androgen production. The monographs of United States Pharmacopeia (USP) reported the list of eleven process‐related impurities for its active pharmaceutical ingredient (API). This article pertains to the identification and synthesis of eight process‐related impurities that were detected during the process development of Abiraterone acetate. The detection and identification of these impurities were accomplished using HPLC and LCMS. Further, the structures of these impurities were confirmed by synthesizing them in moderate to excellent yield and characterized by various orthogonal techniques.
Phthalimides Represent a Promising Scaffold for Multi‐Targeted Anticancer Agents
Authors: Matore Balaji Wamanrao , Banjare Purusottam , Sarthi Ajay Singh , Roy Partha Pratim , Singh Jagadish 
Published: March 2023

AbstractFrom the last two decades, phthalimide analogues received prime interest from scientists due to its potent inhibitory action on different cancer‐causing receptors. A variety of anticancer drugs are coming into the market but challenges of drug resistance, toxicities, and failure in therapy still remain. Cancer is a group of complex disorders it involves multiple receptors. So there is a need of targeting multiple receptors to get desired potent anticancer drugs with minimum harmful effects. Phthalimide scaffolds fit into these criteria as it is extensively reported for the inhibition of different cancer receptors such as VEGFR, HDAC, EGFR, TNF‐α, etc. The multi‐targeted mechanism of phthalimide derivatives plays a major role in anticancer therapy. Due to this advantage, there is the hope of developing some novel effective multi‐targeted anticancer agents. Consider structural features and pharmacological advancement of phthalimide analogues may fulfill the current need of cancer patients. In this review, we covered history, chemistry, SAR, anticancer mechanisms, and the current status of phthalimide derivatives reported till 2022. The article specifically focused on different cancer‐causing receptors inhibited by phthalimide derivatives and their mechanism of action in brief. Finally, we provided the future scope and role of phthalimide derivatives in multi‐targeted anticancer drug discovery.
Fluorometric Detection of Methanol by Using Triphenylamine Fluorophore Tethered Terpyridine Probe
Authors: Jose Karolin P. , Ravi Sasikala , Sivadas Deepanjaly K. , Anthony Savarimuthu Philip , Madhu Vedichi 
Published: March 2023

AbstractTriphenylamine appended terpyridine donor‐acceptor fluorescent probe (TPA‐TP) exhibited specific detection of methanol in presence of other volatile organic compounds, such as benzene, ethanol and biodiesel were described. The role of the terpyridine group in the TPA‐TP toward methanol detection has been demonstrated. The detection mechanism origins from s‐trans to s‐cis and vice‐versa conformational change facilitated by hydrogen bonding interactions between TPA‐TP and methanol. Besides, TPA‐TP coated Whatman filter paper based strip was evaluated for detection of methanol from benzene prepared my means of practical and versatile applications of methanol detection. Thus, TPA‐TP was demonstrated as a sensitive, selective, and inexpensive probe for methanol detection over benzene, ethanol and biodiesel by naked‐eye and fluorescence spectroscopy methods.
Electrochemical Oxidation Involving Sulfonyl Hydrazine for the Synthesis of 2‐Sulfonyl Quinolines/Pyridines
Authors: Wang Luyao , Ning Zhitao , Xu Zheng , Liu Ruikai , Du Zhengyin 
Published: March 2023

AbstractA mild electrochemical method was developed for the direct C2 sulfonylation of heteroaromatic N‐oxides with sulfonyl hydrazides to obtain a serial of 2‐sulfonyl quinoline/pyridine derivatives. The method has simple conditions, using potassium carbonate as base, CH3CN/H2O (9 : 1) as solvent, and reacting for 3 h under 15 mA current to prepare expected products.
Direct and Regioselective C−H Selenylation of 4‐Aminocoumarin Derivatives Mediated by Selectfluor®
Authors: Belladona Andrei Lucca , Cardoso Dilelio Marina , Cargnelutti Roberta , Barcellos Thiago , Cruz Silveira Claudio , Schumacher Ricardo Frederico 
Published: March 2023

AbstractA mild and regioselective approach to the direct selenylation of 4‐(N‐substituted‐amino)‐2H‐chromen‐2‐ones employing Selectfluor® and diorganyl diselenides has been developed. The reactions were carried out under metal‐free conditions, without the need for special devices, and using NaHCO3 as a mild base at room temperature under air. This approach has been suitable for a wide substrate scope affording the 3‐selenyl‐4‐(N‐substituted‐amino)‐2H‐chromen‐2‐ones in good to excellent yields.
Effects of camera trap placement on photo rates of jaguars, their prey, and competitors in northwestern Costa Rica
Authors: Montalvo Victor H. , Sáenz‐Bolaños Carolina , Cruz‐Díaz Juan C. , Kamilar Jason M. , Carrillo Eduardo , Fuller Todd K. 
Published: March 2023

AbstractThe use of camera‐trap methods, though important, has pitfalls and inconsistencies such as factors and interactions that may influence species photo rates. Jaguar (Panthera onca) camera‐trap studies place cameras at sites where jaguar detections are likely greater (e.g., sites with previous evidence such tracks, feces, and other presence signs), but do not account for potential placement biases. Our study evaluated methodological implications of a paired camera‐trap design at trail and off‐trail locations, and climate seasonality, on photo rates of jaguars, their prey, and competitors. From June 2016 to June 2017, camera traps were deployed at 58 different sites in a hexagon grid array of 3 km2 each in the Sector Santa Rosa (SSR) of Área de Conservación Guancaste in Costa Rica. Half of the cameras were located at a trail location that jaguars were likely to use, and the other half at an off‐trail location closest to each hexagon centroid. We estimated a photographic relative abundance index (RAI; no. of independent photos/100 trap nights) and used Generalized Linear Models (GLMs) to assess statistical evidence of trail location and climate seasonality. With a total effort of 19,408 trap nights, we recorded 12,678 independent photo events of 64 species of amphibians, reptiles, birds, and mammals. For the 3 bird species and 14 mammal species we focused on, most species‐specific RAIs were greater at trail locations (n = 8 species, including jaguars and pumas [Puma concolor]), some were greater at off‐trail locations (n = 2 species, including collared peccaries [Pecari tajacu]), and there was no discernable location effect for others (n = 7 species, including tapirs [Tapirus bairdii] and white‐tailed deer [Odocoileus virginianus]). For jaguars, sex ratio data showed a smaller proportion of males at off‐trail locations. Analysis of competitor and prey interaction data indicated temporal segregation at trail locations. Further jaguar camera‐trap studies should highlight camera placement as important source of bias that might influence results; hence, conservationists must be aware of this to avoid erroneous decisions.