bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Plok‐plok” syndrome: Posttraumatic stress disorder following an SEEG thermocoagulation and direct electrical stimulation procedure
Authors: Soncin Lisa‐Dounia , Arthuis Marie , Scholly Julia , Carron Romain , McGonigal Aileen , Pizzo Francesca , Trébuchon Agnès , Lagarde Stanislas , Bartolomei Fabrice 
Published: March 2023

AbstractThe psychological impact of intracerebral electroencephalography (stereoelectroencephalography [SEEG]) including the thermocoagulation procedure has not yet been clearly studied. We present a case of a patient who, following an SEEG procedure for presurgical evaluation of intractable focal epilepsy, developed severe symptoms of posttraumatic stress disorder. Such an occurrence may be under‐estimated. Perceived traumatic exposure during SEEG and the development of posttraumatic psychological symptoms should be further studied in order to define risk factors and to improve the monitoring and psychological management of patients during their hospitalization. A careful and systematic procedure of prevention and support before, during, and after SEEG could decrease the risk of development or worsening of symptoms of anxiety, depression, and posttraumatic stress disorder.
Normal variants and artifacts: Importance in EEG interpretation
Authors: Amin Ushtar , Nascimento Fábio A. , Karakis Ioannis , Schomer Donald , Benbadis Selim R. 
Published: March 2023

AbstractOverinterpretation of EEG is an important contributor to the misdiagnosis of epilepsy. For the EEG to have a high diagnostic value and high specificity, it is critical to recognize waveforms that can be mistaken for abnormal patterns. This article describes artifacts, normal rhythms, and normal patterns that are prone to being misinterpreted as abnormal. Artifacts are potentials generated outside the brain. They are divided into physiologic and extraphysiologic. Physiologic artifacts arise from the body and include EMG, eyes, various movements, EKG, pulse, and sweat. Some physiologic artifacts can be useful for interpretation such as EMG and eye movements. Extraphysiologic artifacts arise from outside the body, and in turn can be divided into the environments (electrodes, equipment, and cellphones) and devices within the body (pacemakers and neurostimulators). Normal rhythms can be divided into awake patterns (alpha rhythm and its variants, mu rhythm, lambda waves, posterior slow waves of youth, HV‐induced slowing, photic driving, and photomyogenic response) and sleep patterns (POSTS, vertex waves, spindles, K complexes, sleep‐related hypersynchrony, and frontal arousal rhythm). Breach can affect both awake and sleep rhythms. Normal variants or variants of uncertain clinical significance include variants that may have been considered abnormal in the early days of EEG but are now considered normal. These include wicket spikes and wicket rhythms (the most common normal pattern overread as epileptiform), small sharp spikes (aka benign epileptiform transients of sleep), rhythmic midtemporal theta of drowsiness (aka psychomotor variant), Cigánek rhythm (aka midline theta), 6 Hz phantom spike–wave, 14 and 6 Hz positive spikes, subclinical rhythmic epileptiform discharges of adults (SREDA), slow‐fused transients, occipital spikes of blindness, and temporal slowing of the elderly. Correctly identifying artifacts and normal patterns can help avoid overinterpretation and misdiagnosis. This is an educational review paper addressing a learning objective of the International League Against Epilepsy (ILAE) curriculum.
The potential of the Lempel–Ziv complexity of the EEG in diagnosing cognitive impairment in patients with temporal lobe epilepsy
Authors: Ren Zhe , Yue Mengyan , Han Xiong , Zhao Zongya , Wang Bin , Hong Yang , Zhao Ting , Wang Na , Zhao Pan , Hong Yingxing , Wang Qi , Zhao Yibo 
Published: March 2023

AbstractAimTo analyze whether the Lempel–Ziv Complexity (LZC) in quantitative electroencephalogram differs between the temporal lobe epilepsy (TLE) patients with or without cognitive impairment (CI) and explore the diagnostic value of LZC for identifying CI in TLE patients.MethodsTwenty‐two clinical features and 20‐min EEG recordings were collected from 48 TLE patients with CI and 27 cognitively normal (CON) TLE patients. Seventy‐six LZC features were calculated for 19 leads in four frequency bands (alpha, beta, delta, and theta). The clinical and LZC features were compared between the two groups. A support vector machine (SVM) was subsequently constructed using the leave‐one‐out method of cross‐validation for LZC features with statistical differences.ResultsRegarding the clinical features, the level of education (p < .001), hippocampal atrophy and sclerosis (p = .029), and depression (p = .037) were statistically different between the two groups. For the LZC features, there were statistically significant differences in the alpha (Fp1, Fz, Cz, Pz, C3, C4, T3, T4, T5, T6, F3, F4, F7, F8, O1, and O2), beta (Fp2), and theta (F7) oscillations. The mean LZC in the alpha band was higher in the TLE‐CI group than that in the CON group, and there were no differences in the remaining bands. The SVM model showed 74.51% accuracy, 79.63% sensitivity, 84.30% F1 score, 68.75% specificity, and .85 area under the curve scores.ConclusionsThe LZC in the alpha band might have the potential to be used as a biomarker for the diagnosis of TLE combined with CI. The TLE‐CI group, on the other hand, exhibited a higher degree of complexity in alpha oscillations, which were widespread and occurred in all brain regions.
Toward a statistical validation of brain signatures as robust measures of behavioral substrates
Authors: Fletcher Evan , Farias Sarah , DeCarli Charles , Gavett Brandon , Widaman Keith , De Leon Fransia , Mungas Dan 
Published: March 2023

AbstractThe “brain signature of cognition” concept has garnered interest as a data‐driven, exploratory approach to better understand key brain regions involved in specific cognitive functions, with the potential to maximally characterize brain substrates of behavioral outcomes. Previously we presented a method for computing signatures of episodic memory. However, to be a robust brain measure, the signature approach requires a rigorous validation of model performance across a variety of cohorts. Here we report validation results and provide an example of extending it to a second behavioral domain. In each of two discovery data cohorts, we derived regional brain gray matter thickness associations for two domains: neuropsychological and everyday cognition memory. We computed regional association to outcome in 40 randomly selected discovery subsets of size 400 in each cohort. We generated spatial overlap frequency maps and defined high‐frequency regions as “consensus” signature masks. Using separate validation datasets, we evaluated replicability of cohort‐based consensus model fits and explanatory power by comparing signature model fits with each other and with competing theory‐based models. Spatial replications produced convergent consensus signature regions. Consensus signature model fits were highly correlated in 50 random subsets of each validation cohort, indicating high replicability. In comparisons over each full cohort, signature models outperformed other models. In this validation study, we produced signature models that replicated model fits to outcome and outperformed other commonly used measures. Signatures in two memory domains suggested strongly shared brain substrates. Robust brain signatures may therefore be achievable, yielding reliable and useful measures for modeling substrates of behavioral domains.
The use of hippocampal grading as a biomarker for preclinical and prodromal Alzheimer's disease
Authors: Morrison Cassandra , Dadar Mahsa , Shafiee Neda , Collins D. Louis ,   For Alzheimer's Disease Neuroimaging Initiative
Published: March 2023

AbstractHippocampal changes are associated with increased age and cognitive decline due to mild cognitive impairment (MCI) and Alzheimer's disease (AD). These associations are often observed only in the later stages of decline. This study examined if hippocampal grading, a method measuring local morphological similarity of the hippocampus to cognitively normal controls (NCs) and AD participants, is associated with cognition in NCs, subjective cognitive decline (SCD), early (eMCI), late (lMCI), and AD. A total of 1620 Alzheimer's Disease Neuroimaging Initiative participants were examined (495 NC, 262 eMCI, 545 lMCI, and 318 AD) because they had baseline MRIs and Alzheimer's disease Assessment Scale (ADAS‐13) and Clinical Dementia Rating—Sum of Boxes (CDR‐SB) scores. In a sub‐analysis, NCs with episodic memory scores (as measured by Rey Auditory Verbal Learning Test, RAVLT) were divided into those with subjective cognitive decline (SCD+; 103) and those without (SCD−; 390). Linear regressions evaluated the influence of hippocampal grading on cognition in preclinical and prodromal AD. Lower global cognition, as measured by increased ADAS‐13, was associated with hippocampal grading: NC (p < .001), eMCI (p < .05), lMCI (p < .05), and AD (p = .01). Lower global cognition as measured increased CDR‐SB was associated with hippocampal grading in lMCI (p < .05) and AD (p < .001). Lower RAVLT performance was associated with hippocampal grading in SCD− (p < .05) and SCD+ (p < .05). These findings suggest that hippocampal grading is associated with global cognition in NC, eMCI, lMCI, and AD. Early changes in episodic memory during pre‐clinical AD are associated with changes in hippocampal grading. Hippocampal grading may be sensitive to progressive changes early in the disease course.
High PD‐L1 expression associates with low T‐cadherin expression and poor prognosis in human papillomavirus‐negative head and neck squamous cell carcinoma
Authors: Wang Qiuju , Zhao Yanzhen , Chen Yan , Chen Yibo , Song Xiaoyu , Zhang Li , He Qiao , Ye Bo , Wu Lichun , Huang Xinyue , Wang Dongsheng 
Published: March 2023

AbstractBackgroundThis study aimed at exploring the correlation between T‐cadherin and programmed death‐ligand 1 (PD‐L1), as well as their prognostic value in patients with human papillomavirus (HPV)‐negative head and neck squamous cell carcinoma (HNSCC).MethodsImmunohistochemical staining was used to identify the protein expression of T‐cadherin and PD‐L1. Spearman linear correlation analysis was used to determine their association. Kaplan–Meier analysis was utilized to plot overall survival (OS) and disease‐free survival (DFS) curves. Cox proportional hazards regression was used to conduct univariate and multivariate analysis.ResultsThe results showed a negative association between protein expression of T‐cadherin and PD‐L1 (r = −0.760, p < 0.001), positive expression of T‐cadherin was associated with a better OS (p < 0.001) and DFS (p < 0.001), while positive PD‐L1 expression was associated with a worse OS (p = 0.002) and DFS (p < 0.001). The expression of T‐cadherin and PD‐L1 were independent prognostic predictors for OS and DFS.ConclusionsIn conclusion, expression of T‐cadherin and PD‐L1 were largely inversely correlated and independent prognostic factors for patients with HPV‐negative HNSCC.
Stress compensation based on interfacial nanostructures for stable perovskite solar cells
Authors: Zhu Cheng , Wang Xi , Li Hangxuan , Wang Chenyue , Gao Ziyan , Zhang Pengxiang , Niu Xiuxiu , Li Nengxu , Xu Zipeng , Su Zhenhuang , Chen Yihua , Zai Huachao , Xie Haipeng , Zhao Yizhou , Yang Ning , Liu Guilin , Wang Xueyun , Zhou Huanping , Hong Jiawang , Gao Xingyu , Bai Yang , Chen Qi 
Published: March 2023

AbstractThe long‐term stability issue of halide perovskite solar cells hinders their commercialization. The residual stress–strain affects device stability, which is derived from the mismatched thermophysical and mechanical properties between adjacent layers. In this work, we introduced the Rb2CO3 layer at the interface of SnO2/perovskite with the hierarchy morphology of snowflake‐like microislands and dendritic nanostructures. With a suitable thermal expansion coefficient, the Rb2CO3 layer benefits the interfacial stress relaxation and results in a compressive stress–strain in the perovskite layer. Moreover, reduced nonradiative recombination losses and optimized band alignment were achieved. An enhancement of open‐circuit voltage from 1.087 to 1.153 V in the resultant device was witnessed, which led to power conversion efficiency (PCE) of 22.7% (active area of 0.08313 cm2) and 20.6% (1 cm2). Moreover, these devices retained 95% of its initial PCE under the maximum power point tracking (MPPT) after 2700 h. It suggests inorganic materials with high thermal expansion coefficients and specific nanostructures are promising candidates to optimize interfacial mechanics, which improves the operational stability of perovskite cells.
Bringing a mentalizing framework to understanding mothers with addiction: The groundbreaking work of Nancy E. Suchman
Authors: Slade Arietta 
Published: March 2023

AbstractNancy Suchman is remembered as a pioneer whose mentalization‐based intervention—Mothering from the Inside Out (MIO)—transformed the treatment of parents struggling with substance use disorders. Specifically, Suchman's work highlighted the neural mechanisms underlying substance use disorders and identified the promotion of parental mentalizing as a key therapeutic focus in enhancing early parent‐child relationships. Her work transformed parenting support models for this population of parents. Several randomized controlled trials (RCT) show the effectiveness of MIO in promoting parental reflective functioning (PRF) and positive relational outcomes in parents with substance use disorders and their children. Suchman's MIO model has since been extended to parenting in many contexts. She is also remembered as a generous colleague, a gifted researcher and clinician, and an inspiration to generations of researchers and practitioners working with parents who aspire to raise healthy, secure children despite multiple challenges and adversities. This special issue compiles the work of researchers inspired by Suchman as they carry on her legacy in examining aspects of parental mentalization. Collectively, the research presented yields confirmation of MIO core assumptions, offers new insights into roles of positive sentiment and savoring in mentalization processes, and presents evaluations of MIO in multiple contexts and with new adaptations.
Sending, receiving, and nonconsensually sharing nude or near‐nude images by youth
Authors: Seto Michael C. , Roche Kailey , Stroebel Melissa , Gonzalez‐Pons Kwynn , Goharian Amanda 
Published: March 2023

AbstractIntroductionThere is growing evidence about the prevalence of sending, receiving, or resharing nude images by youth (sexting). Less is known about the demographic, technology use, and social context correlates of sexting. Using logistic regression, we looked at predictors of sexting behaviors in minors.MethodsParticipants were a market panel sample of 394 youths aged 9–12 and 602 youths aged 13–17 (Mage = 13.5, SD = 2.50, 60.3% females) recruited for an anonymous online survey in the United States. The survey comprised questions about demographic characteristics, sexting behaviors, technology use, attitudes, and perceived norms. The four outcomes were sending nude or near‐nude images or videos (images), receiving images sent without the depicted person's knowledge, nonconsensually resharing images, or having one's own images nonconsensually reshared.ResultsRegression analyses showed gender, gender/sexual minority status, use of dating apps and particular online platforms, self‐sharing and resharing attitudes, and friend norms predicted sending images. Age, resharing attitudes, and friend norms all predicted receiving nude images of other youths. Household income, geographic location, some online platforms, resharing attitudes, and friend norms all predicted nonconsensual resharing of nudes. Age, use of encrypted apps, and friend norms predicted having one's own image nonconsensually reshared.ConclusionsWe partially replicated prior research by finding associations between age and gender. Further, we identified technology use factors including the use of dating apps and particular platforms. Attitudes about sexting and perceived friend norms were robust across sexting behaviors, suggesting these factors are potentially important for intervention.
Process optimization of metabolically engineered Escherichia coliNSK015 fermentation for progressive improvement of 1,3‐propanediol production
Authors: Wong Nonthaporn , Jantama Kaemwich , Cassan Claire Joannis , Taillandier Patricia 
Published: March 2023

AbstractBACKGROUNDPreviously, Escherichia coli NSK015 was developed for high yield of 1,3‐propanediol (1,3‐PDO) production. To further improve 1,3‐PDO concentration, parameters including kLa values with different agitations and impeller numbers, concentrations of coenzyme B12 and feeding strategies during fed‐batch fermentation were investigated.RESULTSIn this study, aerobic conditions at 300 rpm agitation and 1 vvm aeration with two Rushton turbine impellers (kLa = 33.6 h−1) and the concentration of coenzyme B12 at 7.5 μmol L−1 were identified as the best optimized conditions to improve 1,3‐PDO production by the strain. With a two‐pulsed continuous feeding, E. coli NSK015 produced 1,3‐PDO up to 60.3 g L−1 with the 1,3‐PDO yield approaching a theoretical maximum of 0.97 g g−1 and productivity of 0.42 g L−1 h−1 in fed‐batch fermentation, in which concentration was improved about 60% compared to that of batch fermentation.CONCLUSIONThe result indicated the efficiency of E. coli NSK015 in producing 1,3‐PDO under optimal aerobic conditions. The strain could even enhance growth and maintain enzymatic activities involved in the 1,3‐PDO pathway without utilizing antibiotics, isopropyl β‐d‐1‐thiogalactopyranoside (IPTG) or enriching nutrients. Plasmid instability, high production cost related to medium preparation and purification, and waste disposal were not of concern. This may provide a new insight for large‐scale 1,3‐PDO production by E. coli NSK015. Additionally, E. coli NSK015 could be a microbial host model for further developing new 1,3‐PDO‐producing microorganisms regardless of plasmid, inducer, antibiotics and rich nutrients in fermentation medium. © 2023 Society of Chemical Industry (SCI).
Crowned dens syndrome: A case series of 72 patients at eight teaching hospitals in Japan
Authors: Isono Hiroki , Kuno Haruka , Hozumi Takunori , Emoto Ken , Nishiguchi Sho , Sakai Masahiro , Ito Madoka , Kitamura Koichi , Hirose Kazuhito , Hiraoka Eiji , Ishimaru Naoto , Kobayashi Hiroyuki , Tokuda Yasuharu 
Published: March 2023

AbstractBackgroundCrowned dens syndrome (CDS) is characterized by calcification around the odontoid process, accompanied by neck pain. Although CDS is supposedly rare, we regularly diagnose and manage this condition, indicating a perception gap between previous studies and our experience. The purpose of this study was to determine the annual incidence of CDS, time to diagnosis in CDS, as well as the features of CDS.MethodsThe study design was a retrospective case series study conducted at eight teaching hospitals in Japan. We identified CDS cases from April 2013–March 2015. CDS was diagnosed when patients had acute onset of neck pain and CT showed calcification around the dens and when other diagnoses were unlikely.ResultsSeventy‐two CDS cases were identified. Mean annual incidence was 4.6 ± 2.3 cases at each hospital. Among those with available data, 57 of 64 had limited rotation (89.1%). The diagnosis of CDS was made in general internal medicine or the emergency medicine department in 61 cases (84.7%). A total of 62 cases (86.1%) were diagnosed within 1 day of presentation, and the median time from initial presentation at the hospital to diagnosis was 0.0 days (25th–75th percentiles, 0.0–1.0). For treatment, NSAIDs were used in 56cases (77.8%) and acetaminophen in 20 cases (27.8%).ConclusionCDS might be more common than has been reported to date. Time to diagnosis of CDS was within 1 day of visiting a teaching hospital. Cervical motion restriction is common in CDS and may be useful in establishing the diagnosis.
Consider hospice in end‐stage liver disease prognostic scale to open discussions regarding six‐month mortality
Authors: Brown Cristal , Aksan Nazan , Muir Andrew Joseph 
Published: March 2023

AbstractBackground and AimHospice is underutilized in the management of patients with end‐stage liver disease and may improve the patient experience at the end of life. This study aims to create a novel prognostic scale to accurately predict 6‐month mortality to more comprehensively facilitate hospice referral.MethodsSociodemographic, clinical, and laboratory variables associated with mortality from the United Network for Organ Sharing database were tested in univariate analysis followed by multivariate analyses with four predictor groups: Demographics, Diagnoses, Complexities, and Laboratory studies to develop the hospice in end‐stage liver disease prognostic scale (HELP) scale (70% sample, N = 13 516) followed with replication in a 30% (N = 5792) internal validation sample.ResultsOnly the predictor groups of Complexities and Laboratory studies met the c‐statistic threshold of 0.70 for inclusion in the multivariate analyses. Backward elimination in the final logistic regression and validated weighted transformation procedure resulted in: HELP scale = (functional status × 11) + (ascites × 3) + (SBP × 3) + (HE × 4) + (dialysis × 5) + (TIPS × −3) + (albumin × −3) + (MELD‐Na ≥ 21 × 20). HELP scale had a strong predictive value for six‐month mortality with Area under the Receiver Operating Curve (AUROC) 0.816 and replicated in the validation sample.ConclusionHELP scale is a novel prognostic score utilizing the strength of model of end‐stage liver disease‐sodium (MELD‐Na), along with clinical factors, for a more nuanced assessment of six‐month mortality. This scale can provide an individualized approach in opening discussions of hospice referral and may be better accepted by patients and providers given its contextualization of important clinical factors.
Autologous peripheral blood stem cell transplantation for Philadelphia chromosome‐positive acute lymphoblastic leukemia is safe but poses challenges for long‐term maintenance of molecular remission: Results of the Auto‐Ph17 study
Authors: Nishiwaki Satoshi , Sugiura Isamu , Sato Takahiko , Kobayashi Miki , Osaki Masahide , Sawa Masashi , Adachi Yoshitaka , Okabe Motohito , Saito Shigeki , Morishita Takanobu , Kohno Akio , Nishiyama Takahiro , Iida Hiroatsu , Kurahashi Shingo , Kuwatsuka Yachiyo , Sugiyama Daisuke , Ito Sachiko , Nishikawa Hiroyoshi , Kiyoi Hitoshi 
Published: March 2023

AbstractAutologous hematopoietic stem cell transplantation (SCT) is not a standard treatment option for Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph+ALL); however, its position has been reassessed since the introduction of tyrosine kinase inhibitors (TKIs). We prospectively analyzed the efficacy and safety of autologous peripheral blood SCT (auto‐PBSCT) for Ph+ALL patients aged between 55 and 70 years who had achieved complete molecular remission. Melphalan, cyclophosphamide, etoposide, and dexamethasone were used for conditioning. A total of 12 courses of maintenance therapy, including dasatinib, were performed. The required number of CD34+ cells was harvested in all five patients. No patient died within 100 days after auto‐PBSCT, and no unexpected serious adverse events were observed. Although 1‐year event‐free survival was 100%, hematological relapse was observed in three patients at a median of 801 days (range, 389–1088 days) after auto‐PBSCT. Molecular progressive disease was observed in the other two patients, although they maintained their first hematological remission at the last visit. Auto‐PBSCT can be safely performed for Ph+ALL with TKIs. A limitation of auto‐PBSCT was suggested, despite the increase in the intensity of a single treatment. The development of long‐term therapeutic strategies by including new molecular targeted drugs is warranted to maintain long‐term molecular remission.