bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of predictive factors associated with the technical difficulty of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma: Japanese multicenter retrospective study
Authors: Yamamoto Yoshinobu , Yoshizaki Tetsuya , Kushida Saeko , Tanaka Shinwa , Ose Takayuki , Ishida Tsukasa , Kitamura Yasuaki , Sako Tomoya , Iwatate Mineo , Ikeda Atsushi , Ariyoshi Ryusuke , Kawara Fumiaki , Abe Hirofumi , Takao Toshitatsu , Morita Yoshinori , Sano Yasushi , Umegaki Eiji , Nishisaki Hogara , Toyonaga Takashi , Kodama Yuzo 
Published: August 2023

ObjectivesEndoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) is performed for the treatment of lesions with varied backgrounds and factors. However, the predictive factors associated with the technical difficulty of ESD remain unknown in patients with varied lesions. Therefore, this study aimed to identify the predictive factors associated with the technical difficulty of ESD for ESCC using a retrospective cohort.MethodsThis multicenter, retrospective study was conducted in 10 hospitals in Japan. Consecutive patients who underwent esophageal ESD between January 2013 and December 2019 were enrolled. Lesions of subepithelial tumors, adenocarcinoma, and adenoma were excluded. Difficult lesions were defined as ESD requiring a long procedure time (≥120 min), perforation development, piecemeal resection, or discontinued ESD. In the present study, the clinical factors were assessed to identify the technical difficulty of ESD using univariate and multivariate analyses.ResultsAmong 1708 lesions treated with esophageal ESD, eight subepithelial tumors, 44 adenocarcinomas, and two adenomas were excluded. Finally, 1505 patients with 1654 lesions were analyzed, and 217 patients with 217 lesions (13.1%) were classified as patients with difficult lesions. In multivariate analysis, the predictive factors associated with the technical difficulty of ESD were as follows: tumors with varices, tumors with diverticulum, antiplatelet use (discontinued), circumference of tumor (≥1/2), preoperative tumor size ≥30 mm, trainee, and nonhigh‐volume center.ConclusionThis multicenter retrospective study identified the predictive factors associated with the technical difficulty of ESD for ESCC with varied backgrounds and factors.
Pandemic exposure and long‐run psychological well‐being
Authors: Ma Chao , Li Yiwei , Jiang Wenxin , Zhang Xing 
Published: August 2023

AbstractUsing individuals' life history information from a large‐scale national survey (N = 13,044), we causally evaluate how exposure to SARS‐Cov‐1, the first global pandemic in the 21st century, affects long‐term psychological well‐being. We find that exposure to local pandemic risk, that is, local deaths due to the pandemic, significantly reduced people's mental health 12 years later. Consistent with the belief‐based account of depression, exposure to pandemic risk resulted in more pessimistic beliefs about the future and survival probability. People reduced savings and increased hedonic consumption, suggesting a “carpe diem” effect of the pandemic exposure.
Acceptability and utility of digital well‐being and mental health support for university students: A pilot study
Authors: Pankow Kurtis , King Nathan , Li Melanie , Byun Jin , Jugoon Liam , Rivera Daniel , Dimitropoulos Gina , Patten Scott , Kingslake Jonathan , Keown‐Stoneman Charles , Duffy Anne 
Published: August 2023

AbstractAimTo assess the acceptability and explore the utility of a novel digital platform designed as a student‐facing well‐being and mental health support.MethodsAn adapted version of i‐spero® was piloted as a student‐facing well‐being support and as part of routine university‐based mental health care. In both pathways, student participants completed baseline demographics and brief validated measures of well‐being and mental health. Weekly measures of anxiety (GAD‐7) and depression (PHQ‐9) and a Week 8 Experience Survey were also scheduled. Integrated mixed methods analysis was used to assess acceptability and explore the utility of these platforms.ResultsStudents in the well‐being (n = 120) and care pathways (n = 121) were mostly female and between 19 and 22 years of age. Baseline screen positive rates for anxiety and depression were high in both the well‐being (68%) and care pathways (80%). There was a substantial drop in adherence over Week 1 (50% well‐being; 40% care) followed by minor attrition up to Week 8. Anxiety and depressive symptom levels improved from baseline in students who dropped out after Week 1 (p ≤ .06). The student experience was that i‐spero® improved their emotional self‐awareness, understanding of progress in care, and knowledge about when to seek help. Most students agreed (>75%) that i‐spero® should form part of regular university student wellness support.ConclusionsDigital well‐being and mental health support seems acceptable to university students; however, engagement and persistence are areas for further development. Such digital tools could make a positive contribution to an evidence‐based stepped approach to student well‐being and mental health support.
Validity and reliability of the Spanish version of the consultation and relational empathy measure in dental students (Sp‐Dent‐CARE): A cross‐sectional study
Authors: Sánchez‐Torres Alba , Camps‐Font Octavi , Figueiredo Rui , Valmaseda‐Castellón Eduard 
Published: August 2023

AbstractIntroductionAn evaluation was made of the psychometric properties of a Spanish version of the Consultation and Relational Empathy Measure (CARE) to assess relational empathy in undergraduate dental students. In addition, the influence of demographic, socio‐economic and consultation‐related factors upon the degree of perceived empathy and overall satisfaction was studied.Materials and MethodsA cross‐sectional study was carried out in patients seen in the Oral Surgery Unit by fourth year dental students. Dentists, specialized translators and psychologists developed the translation of the questionnaire. After a pilot test, a convenience sample of patients was included. Construct validity was tested by factor analysis using principal component analysis with varimax rotation and Kaiser standardization, and internal consistency was assessed by Cronbach's α.ResultsTwo pilot tests were carried out with a panel of experts until the final version of the questionnaire was established. In the validation stage, 191 patients participated (92 men and 99 women), with a mean age of 52.5 ± 17 years. The mean score of the CARE measure was 47.2 ± 4.4, and 57.6% of the patients (n = 110) reported the maximum score on the questionnaire. The final version showed a 1‐factor solution explaining 68.6% of the total variance, with excellent final internal consistency (α = 93.4%).ConclusionThe Spanish version of the CARE measure affords high reliability and validity in assessing relational empathy in dental students. Perceived empathy is related to overall satisfaction. Patient demographics and the number of visits do not influence perceived empathy.
Effects of transcranial magnetic stimulation (TMS) current direction and pulse waveform on cortico‐cortical connectivity: A registered report TMS‐EEG study
Authors: Guidali Giacomo , Zazio Agnese , Lucarelli Delia , Marcantoni Eleonora , Stango Antonietta , Barchiesi Guido , Bortoletto Marta 
Published: August 2023

AbstractTranscranial magnetic stimulation (TMS)‐evoked potentials (TEPs) are a promising proxy for measuring effective connectivity, that is, the directed transmission of physiological signals along cortico‐cortical tracts, and for developing connectivity‐based biomarkers. A crucial point is how stimulation parameters may affect TEPs, as they may contribute to the general variability of findings across studies. Here, we manipulated two TMS parameters (i.e. current direction and pulse waveform) while measuring (a) an early TEP component reflecting contralateral inhibition of motor areas, namely, M1‐P15, as an operative model of interhemispheric cortico‐cortical connectivity, and (b) motor‐evoked potentials (MEP) for the corticospinal pathway. Our results showed that these two TMS parameters are crucial to evoke the M1‐P15, influencing its amplitude, latency, and replicability. Specifically, (a) M1‐P15 amplitude was strongly affected by current direction in monophasic stimulation; (b) M1‐P15 latency was significantly modulated by current direction for monophasic and biphasic pulses. The replicability of M1‐P15 was substantial for the same stimulation condition. At the same time, it was poor when stimulation parameters were changed, suggesting that these factors must be controlled to obtain stable single‐subject measures. Finally, MEP latency was modulated by current direction, whereas non‐statistically significant changes were evident for amplitude. Overall, our study highlights the importance of TMS parameters for early TEP responses recording and suggests controlling their impact in developing connectivity biomarkers from TEPs. Moreover, these results point out that the excitability of the corticospinal tract, which is commonly used as a reference to set TMS intensity, may not correspond to the excitability of cortico‐cortical pathways.
A conflict escalation comparison: Couples from the general population and couples engaged in high‐intensity conflict
Authors: Sowan Wafaa 
Published: August 2023

AbstractObjectiveThe purpose of the present study was to test a model that examines the characteristics of the escalation process among heterosexual couples. It also examined how women's use of verbal and physical violence is associated with a sense of danger in men.BackgroundThe prevalence of intimate partner violence (IPV) is a critical concern for public health. IPV has serious physical and mental health consequences on the victim.MethodsParticipants were 165 women. The first subsample (n = 70, 42.42%) comprised women from the general population, and the second (n = 95, 57.57%) was composed of women living in relationships characterized by high‐intensity conflict (research population). Structural equation modeling was performed to assess the hypothesized model and to test the research hypotheses.ResultsAnalysis indicates that the use of violence (verbal and/or physical) by one partner was positively correlated to the use of violence by the other partner. The analysis also shows that the woman's use of violence positively affects the man's sense of danger only for couples from the general population. Finally, the man's sense of danger is related to his violence toward the woman.ConclusionIn a high‐conflict relationship, violence is less reciprocal but escalates more easily, whereas in the general population, violence is more reciprocal but more moderate. In addition, emotions are an essential component of marital conflict and influence the development and management of conflict. Emotional components, such as a sense of danger, may be a risk factor in the escalation of conflict to violence.
Potentiating‐antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi‐drug resistant (MDR) strains
Authors: de Araújo Ana Carolina Justino , Freitas Priscilla Ramos , Araújo Isaac Moura , Siqueira Gustavo Miguel , de Oliveira Borges João Arthur , Alves Daniel Sampaio , Miranda Gustavo Marinho , dos Santos Nascimento Igor José , de Araújo‐Júnior João Xavier , da Silva‐Júnior Edeildo Ferreira , de Aquino Thiago Mendonça , Junior Francisco Jaime Bezerra Mendonça , Marinho Emmanuel Silva , dos Santos Helcio Silva , Tintino Saulo Relison , Coutinho Henrique Douglas Melo 
Published: August 2023

AbstractBackgroundThiadiazines are heterocyclic compounds that contain two nitrogen atoms and one sulfur atom in their structure. These synthetic molecules have several relevant pharmacological activities, such as antifungal, antibacterial, and antiparasitic.ObjectivesThe present study aimed to evaluate the possible in vitro and in silico interactions of compounds derived from thiadiazines.MethodsThe compounds were initially synthesized, purified, and confirmed through HPLC methodology. Multi‐drug resistant bacterial strains of Staphylococcus aureus 10 and Pseudomonas aeruginosa 24 were used to evaluate the direct and modifying antibiotic activity of thiadiazine derivatives. ADMET assays (absorption, distribution, metabolism, excretion, and toxicity) were conducted, which evaluated the influence of the compounds against thousands of macromolecules considered as bioactive targets.ResultsThere were modifications in the chemical synthesis in carbon 4 or 3 in one of the aromatic rings of the structure where different ions were added, ensuring a variability of products. It was possible to observe results that indicate the possibility of these compounds acting through the cyclooxygenase 2 mechanism, which, in addition to being involved in inflammatory responses, also acts by helping sodium reabsorption. The amine group present in thiadiazine analogs confers hydrophilic characteristics to the substances, but this primary characteristic has been altered due to alterations and insertions of other ligands. The characteristics of the analogs generally allow easy intestinal absorption, reduce possible hepatic toxic effects, and enable possible neurological and anti‐inflammatory action. The antibacterial activity tests showed a slight direct action, mainly of the IJ23 analog. Some compounds were able to modify the action of the antibiotics gentamicin and norfloxacin against multi‐drug resistant strains, indicating a possible synergistic action.ConclusionsAmong all the results obtained in the study, the relevance of thiadiazine analogs as possible coadjuvant drugs in the antibacterial, anti‐inflammatory, and neurological action with low toxicity is clear. Need for further studies to verify these effects in living organisms is not ruled out.
Daidara: A gigantic Gypsy LTR retrotransposon lineage in the springtail Allacma fusca genome
Authors: Kojima Kenji K. 
Published: August 2023

AbstractLong terminal repeat (LTR) retrotransposons are the major contributor to genome size expansion, as in the cases of the maize genome or the axolotl genome. Despite their impact on the genome size, the length of each retrotransposon is limited, compared to DNA transposons, which sometimes exceed over 100 kb. The longest LTR retrotransposon known to date is Burro‐1 from the planarian Schmidtea medierranea, which is around 35.7 kb long. Here through bioinformatics analysis, a new lineage of gigantic LTR retrotransposons, designated Daidara, is reported from the springtail Allacma fusca genome. Their entire length (25–33 kb) rivals Burro families, while their LTRs are shorter than 1.5 kb, in contrast to other gigantic LTR retrotransposon lineages Burro and Ogre, whose LTRs are around 5 kb long. Daidara encodes three core proteins corresponding to gag, pol, and an additional protein of unknown function. The phylogenetic analysis supports the independent gigantification of Daidara from Burro or Ogre.
Effect on BN interphase thickness upon SiCnws@BN/HfC coating performance under impact and ablation environment
Authors: Tong Mingde , Fu Qiangang , Feng Tao , Dai Ying , Hou Wanbo , He Pengfei 
Published: August 2023

AbstractTo inhibit the negative influence of impact on ablation performance of HfC coating reinforced by SiC nanowires (SiCnws/HfC coatings), BN interphases were fabricated and introduced into SiCnws/HfC coatings by chemical vapor deposition. The effect on BN interphase thickness upon SiCnws@BN/HfC coatings performance under impact‐ablation environment was investigated. The interphase thickness was adjusted by changing the deposition time of BN. Impact and ablation tests were carried out by drop hammer and oxyacetylene ablation devices. Among the prepared coatings, the one with 150 ± 20 nm thickness interphase possessed a good performance under impact test, of which the crack propagation path exhibited a significant deflection. After ablation, the coating could still maintain intact surface, because the interphase thickness of 150 ± 20 nm was appropriate to ensure the toughness of the coating and to avoid the porous structure formation.
From Detractors to Promoters: A comparative analysis of patient experience drivers across Net Promoter Score subcategories
Authors: Adams Corey , Harrison Reema , Iqbal Maha Pervaz , Schembri Anthony , Walpola Ramesh 
Published: August 2023

AbstractBackgroundThe utilization of patient experience surveying by health care institutions has become increasingly prevalent, yet its effectiveness in promoting quality improvement remains uncertain. To enhance the utility of patient feedback, the examination of free‐text comments may provide valuable insights to guide patient experience strategy.AimsThis study aims to explore the utility of free‐text comments and identify key differences for patient experience drivers between Net Promoter Score (NPS) subcategories of Detractors, Passives, and Promoters.MethodsEvaluation and classification of comments was conducted using the eight Picker Principles of Person Centred Care, with descriptive analysis of patient comments performed on the NPS data.ResultsAnalysis of patient NPS comments can be classified into three key drivers: “feeling well‐treated” (for Detractors), “feeling comfortable” (for Passives), and “feeling valued” (for Promoters). Specifically, Detractor comments provided the most comprehensive and detailed feedback to guide patient experience improvement activities.ConclusionThis study highlights differences between NPS subcategories, particularly regarding aspects of safety, comfort, and feeling valued. Comments from Detractor respondents may be especially useful for guiding quality improvements due to increased specificity and insights. These results also emphasize the essential nature of empathy and compassionate interactions between patients and clinicians to achieve the highest level of patient satisfaction and experience.
Impact of spinal Anaesthesia versus general Anaesthesia on the incidence of surgical site infections after knee or hip arthroplasty: A meta‐analysis
Authors: Li Zhizhuo , Xu Xingquan , Zhuang Zaikai , Lu Jun , Gao Fuqiang , Jiang Qing 
Published: August 2023

AbstractPostoperative Surgical Site Infections (SSIs) pose significant challenges to recovery after joint arthroplasty. This systematic review and meta‐analysis aim to compare the incidence of SSIs after knee or hip arthroplasty under Spinal Anaesthesia (SA) versus general anaesthesia (GA). We conducted the systematic review and meta‐analysis following the PRISMA guidelines, analysing data from 15 studies selected from PubMed, Embase, Web of Science, and Cochrane Library up to May 16, 2023. The analysis included studies comparing SSIs incidence in patients aged 18 years and above who underwent knee or hip arthroplasty under SA or GA. Quality assessment was performed using the Cochrane Collaboration's risk of bias tool. The effect size was calculated using random or fixed‐effects models based on the observed heterogeneity. We assessed the heterogeneity between studies and conducted a sensitivity analysis. Of 1651 initially identified studies, 15 articles encompassing 353 169 patients were included in the final analysis. A total of 156 405 patients were under SA, while 196 764 received GA. The studies demonstrated substantial heterogeneity (p = 0.007, I2 = 53.7%), resulting in a random‐effects model being employed. Patients receiving SA showed a 23% lower likelihood of developing SSIs postoperatively compared to GA patients (OR: 0.77, 95% CI: 0.70–0.86, p < 0.001). Sub‐group analysis further confirmed these findings regardless of the type of joint arthroplasty. This meta‐analysis indicated a significantly lower incidence of SSIs following knee or hip arthroplasty under SA compared to GA. Despite observed heterogeneity, the results underscore the potential benefit of SA over GA in orthopaedic surgeries to reduce the risk of SSIs.
Die beruhigende Wirkung der Partner‐Nähe bei der monogamen Garnele Hymenocera picta
Authors: Seibt Uta 
Published: August 2023

ZusammenfassungEinzeln sitzende Individuen der normalerweise in Paaren lebenden Garnele Hymenocera picta zeigen eine doppelt so hohe allgemeine Aktivität als nahe beim Partner sitzende.Das Aufsuchen der Partners, an dem man die Paarbindung erkennt, wird als Appetenzverhalten nach dem vom Partner vermittelten Ruhezustand gedeutet. Der Zusammenhang zwischen unspezifischer Aktivierung, Appetenzverhalten und Stress wird erörtert.
Microstructure, dielectric, and piezoelectric properties of BiFeO3–SrTiO3 lead‐free ceramics
Authors: Wang Shenghao , Liu Hongbo , Wang Yuanyuan , Qin Hailan , Zhao Jianwei , Lu Zhilun , Mao Zhu , Wang Dawei 
Published: August 2023

AbstractBiFeO3–SrTiO3 (BF–ST) ceramics have been considered a novel class of lead‐free dielectric materials exhibiting notable dielectric constants and remarkable thermal stability. In this work, we fabricated a series of (1 − x)BF–xST (0.32 ≤ x ≤ 0.44) ceramics near the morphotropic phase boundary and comprehensively investigated their microstructure and electrical properties, which seeks to optimize the piezoelectric performance. As the ST content increases, a gradual reduction in the rhombohedral phase fraction is observed alongside a corresponding increase in the cubic phase fraction. Although x = 0.38, the maximum grain size of 5.66 μm is obtained, accompanied by a distinctive heterogeneous core–shell microstructure, which demonstrates a high remanent polarization of 51.2 μC/cm2 and a maximum d33 value of 72 pC/N. Furthermore, impedance spectroscopy analysis reveals the formation of a conductive core and a nonconductive shell within the sample. These findings highlight the potential of optimized BF–ST ceramics as promising alternatives to lead‐based piezoelectric materials, offering exceptional ferroelectric and piezoelectric properties.
Microstructure and mechanical property of thick Cu/AlN joints formed at low temperature
Authors: Chen Shu , Xu Zhiwu , Ma Zhongwei , Li Zhengwei , Yan Jiuchun 
Published: August 2023

AbstractThe bonding of thick Cu and AlN is necessary in power modules with the development of high‐frequency communication technology. In this work, 2 mm‐thick Cu was successfully bonded with AlN by using Sn9Zn solder with the assistance of ultrasonication at 230°C. Results showed that an AlN/Sn9Zn/Cu joint without crack was manufactured with a cooling rate of 7°C/min. Nonreactive wetting was realized between AlN and Sn9Zn, forming an amorphous transition layer. CuZn2 and CuZn were formed at the Sn9Zn/Cu interface. A joint with the highest bonding strength of 30.07 MPa was obtained, in which the AlN/Sn9Zn interface was no longer the weakest location. This work provides a low‐temperature manufacturing method for thick Cu/AlN joints.
Hard piezoelectric properties of lead‐free BiFeO3–BaTiO3 ceramics
Authors: Lee Myang Hwan , Choi Hae In , Kim Da Jeong , Kim Ji Su , Song Tae Kwon 
Published: August 2023

AbstractHard piezoelectric properties are investigated in lead‐free BiFeO3–BaTiO3 (BF–BT) ceramics. Rhombohedral (R) phase ceramics of (1 – x)BF–xBT (x = 0.20–0.30) were prepared using a conventional solid‐state reaction and water‐quenching process. The R structure is observed in x = 0.20–0.275, and the R and tetragonal phases coexist at x = 0.30. The piezoelectric charge sensor coefficient (d33) and electromechanical planar coupling factor (kp) increase with increasing BT content, whereas the mechanical quality factor (Qm) decreases. The x = 0.20 ceramic shows the best hard piezoelectric properties: the highest Qm = 403 and the highest TC = 607°C. In contrast, x = 0.30 ceramic shows soft piezoelectric properties: d33 = 301 pC/N and kp = 0.33 with TC = 510°C. These results show that the BF–BT system in R‐phase‐rich region has good hard piezoelectric properties for transducer applications.