bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-care educational guide for mothers with gestational diabetes mellitus: A systematic review on identifying self-care domains, approaches, and their effectiveness
Authors: Haron Zarina , Sutan Rosnah , Zakaria Roshaya , Abdullah Mahdy Zaleha 
Published: February 2023

Background: Gestational Diabetes Mellitus (GDM) is a common form of poor carbohydrate intolerance, prevalent among pregnant women and associated with unhealthy lifestyle behaviors. Given the dearth of information on self-empowerment among mothers with GDM, a self-care health education package needs to be developed to prevent related complications.
Objective: This review aimed to identify self-care approaches, domains, and their effectiveness for a proper self-care educational guide package for women with GDM.
Design: A systematic review using electronic literature databases published between January 2016 and December 2022 was conducted.
Data Sources: Web of Science, Scopus, and Ovid databases were used.
Review Methods: This review utilized the PICO (Population, Intervention, Comparison, and Outcomes) framework to screen the retrieved articles for eligibility in which mothers with GDM, educational materials, standard practice or intervention, and effectiveness were considered the PICO, respectively. The CIPP (Context, Input, Process, Product) model served as a framework for adopting the education development model. Mixed methods appraisal tool was used for quality assessment. Data extraction and synthesis without meta-analysis were presented as evidence tables.
Results: A total of 19 articles on GDM were included in the final analysis (16 Intervention studies, two qualitative studies, and one mixed-methods study). Four broad domains emerged from the analysis: 1) information or knowledge of GDM, 2) monitoring of blood glucose levels, 3) practice of healthy lifestyles, and 4) other non-specific activities. The majority of the articles employed a face-to-face approach in executing the educational group sessions, and most studies disclosed their positive effects on GDM management. Other methods of evaluating intervention effectiveness were described as improved self-care behavior, increased satisfaction score, enhanced self-efficacy, good glucose control, and better pregnancy outcome.
Conclusion: Knowledge or information about GDM, healthy diet, and exercise or physical activity was found to be the most applied domains of intervention. Framework domains based on the present review can be used in the future development of any interventional program for GDM women in enhancing health information reaching the targeted group in promoting self-efficacy.
PROSPERO registration number: CRD42021229610.
The effect of the multimodal intervention on blood pressure in patients with first ischemic stroke: A randomized controlled trial
Authors: Jullmusi Orapin , Yunibhand Jintana , Jitpanya Chanokporn 
Published: February 2023

Background: Multimodal intervention is currently promoted to control blood pressure in patients with first ischemic stroke. However, a dearth of studies has examined the influence of the intervention among patients with ischemic stroke, particularly in Thailand. Objective: This study aimed to determine the effect of the multimodal intervention on blood pressure in patients with first ischemic stroke. Methods: A randomized controlled trial was conducted. Sixty participants were randomly selected from two tertiary hospitals in Thailand. Eligible participants were randomly assigned into an experimental group (n = 30) and a control group (n = 30). The experimental group was provided with the multimodal intervention, while the control group was given the usual care. Data were collected from May 2021 to October 2021 at baseline (pre-test), 4th week, 8th week, and 12th week using the demographic data form and sphygmomanometer. The data were analyzed using the Chi-square test, t-test, and repeated measure analysis of variance (ANOVA). Results: The participants’ blood pressures after receiving the multimodal intervention were lower than those before receiving the multimodal intervention. Both systolic and diastolic blood pressure were statistically significantly decreased over time, starting from baseline to the 8th week and 12th week (p <0.001). In addition, the participants’ mean scores of systolic blood pressure (F (1, 58) = 4.059, p = 0.049) and diastolic blood pressure (F (1, 58) = 4.515, p = 0.038) were lower than the control group. Conclusion: The multimodal intervention is effective in controlling blood pressure. Therefore, nurses should educate patients with ischemic stroke to manage systolic and diastolic blood pressure, facilitate the patient’s participation in the exercise program, and monitor the patients via telephone to continue blood pressure control. Trial Registry: Thai Clinical Trials Registry (TCTR) identifier number 20210318001.
A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization
Authors: Xi Xiaozhi , Xiao Guokai , An Guiqi , Liu Lin , Liu Xiaochun , Hao Peiyu , Wang Jennifer Yiyang , Song Dandan , Yu Wengong , Gu Yuchao 
Published: February 2023

IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA). Thousands of proteins, that are involved in various physiological and pathological processes, have been found to be O-GlcNAcylated. However, due to the lack of favorable tools, studies of the O-GlcNAcylation and OGT were impeded. Immunoglobulin new antigen receptor (IgNAR) derived from shark is attractive to research tools, diagnosis and therapeutics. The variable domain of IgNARs (VNARs) have several advantages, such as small size, good stability, low-cost manufacture, and peculiar paratope structure.MethodsWe obtained shark single domain antibodies targeting OGT by shark immunization, phage display library construction and panning. ELISA and BIACORE were used to assess the affinity of the antibodies to the antigen and three shark single-domain antibodies with high affinity were successfully screened. The three antibodies were assessed for intracellular function by flow cytometry and immunofluorescence co-localization.ResultsIn this study, three anti-OGT VNARs (2D9, 3F7 and 4G2) were obtained by phage display panning. The affinity values were measured using surface plasmon resonance (SPR) that 2D9, 3F7 and 4G2 bound to OGT with KD values of 35.5 nM, 53.4 nM and 89.7 nM, respectively. Then, the VNARs were biotinylated and used for the detection and localization of OGT by ELISA, flow cytometry and immunofluorescence. 2D9, 3F7 and 4G2 were exhibited the EC50 values of 102.1 nM, 40.75 nM and 120.7 nM respectively. VNAR 3F7 was predicted to bind the amino acid residues of Ser375, Phe377, Cys379 and Tyr 380 on OGT.DiscussionOur results show that shark single-domain antibodies targeting OGT can be used for in vitro detection and intracellular co-localization of OGT, providing a powerful tool for the study of OGT and O-GlcNAcylation.
Opium consumption and long-term outcomes of CABG surgery in patients without modifiable risk factors
Authors: Sheikhy Ali , Fallahzadeh Aida , Nayebirad Sepehr , Nalini Mahdi , Sadeghian Saeed , Pashang Mina , Shirzad Mahmoud , Salehi-Omran Abbas , Mansourian Soheil , Bagheri Jamshid , Hosseini Kaveh 
Published: February 2023

BackgroundThe question about the significance of opium consumption as a coronary artery disease (CAD) risk factor still remains open. The present study aimed to evaluate the association between opium consumption and long term outcomes of coronary artery bypass grafting (CABG) in patients without standard modifiable CAD risk factors (SMuRFs; hypertension, diabetes, dyslipidemia, and smoking).MethodsIn this registry-based design, we included 23,688 patients with CAD who underwent isolated CABG between January 2006 to December 2016. Outcomes were compared in two groups; with and without SMuRF. The main outcomes were all-cause mortality, fatal and nonfatal cerebrovascular events (MACCE). Inverse probability weighting (IPW) adjusted Cox's proportional hazards (PH) model was used to evaluate the effect of opium on post-op outcomes.ResultsDuring 133,593 person-years of follow-up, opium consumption was associated with increased risk of mortality in both patients with and without SMuRFs (weighted Hazard Ratio (HR)s: 1.248 [1.009, 1.574] and 1.410 [1.008, 2.038], respectively). There was no association between opium consumption and fatal and non-fatal MACCE in patients without SMuRF (HR = 1.027 [0.762–1.383], HR 0.700 [0.438–1.118]). Opium consumption was associated with earlier age of CABG in both groups; 2.77 (1.68, 3.85) years in SMuRF-less and 1.70 (1.11, 2.38) years in patients with SMuRFs.ConclusionOpium users not only undergo CABG at younger ages but also have a higher rate of mortality regardless of the presence of traditional CAD risk factors. Conversely, the risk of MACCE is only higher in patients with at least one modifiable CAD risk factor.
Sistem Pakar Rekomendasi Menu Makanan Sehat Penderita Penyakit dengan Metode Forward Chaining
Authors: Sufi Husin , Utomo Danang Wahyu , Darmawati Gusnita 
Published: February 2023

Makanan adalah sumber penting kehidupan bagi manusia untuk keberlangsungan hidup. Banyak sekali makanan di dunia ini, namun pada dasarnya ada 2 sumber jenis makanan yang diolah pada kehidupan sehari-hari, yaitu hewani dan nabati. Makanan memiliki keterkaitan erat terhadap penyakit yang diderita manusia. Apabila makanan yang dikonsumsi tidak tepat maka akan menimbulkan penyakit bawaan sebelumnya dan menjadi penyakit yang lebih serius atau kambuh. Penyakit kolestrol adalah penyakit yang paling serius dan banyak menyerang kesehatan manusia. Penyakit ini disebabkan oleh konsumsi makanan yang tidak sehat secara terus menerus sehingga kandungan lemak menumpuk didalam tubuh. Kadar kolsetrol yang menumpuk akan mengakibatkan tingginya kadar kolsetrol serta dapat memicu penyakit yang berkelanjutan seperti penyakit jantung coroner. Tujuan penelitian ini adalah membangun sistem pakar rekomendasi menu makanan sehat penderita penyakit kolesterol. Sistem pakar yang dibangun menggunakan metode forward chaining dalam proses pendiagnosaan yang didasari pengetahuan pakar. Hasil penelitian ini menyajikan sebuah sistem pakar yang mampu mendiagnosa dalam rekomendasi menu makanan bagi penderita penyakit kolesterol secara tepat dan akurat. Hasil tersebut tersaji dalam sebuah sistem yang dibangun menggunakan pemograman berbasis android. Sistem pakar ini ini dapat digunakan oleh pasien penderita kolestrol dimana saja kapan saja, pasien penderita kolestrol tidak perlu bentemu langsung dengan pakar gizi cukup mengakses aplikasi tersebut dari android masing-masing pasien. Secara keseluruhan hasil penelitian ini dapat memberikan kontribusi positif bagi para penderita kolestrol dalam menentukan menu makanan sehat yang bisa dikunsumsi.
Analisis Sentimen Relokasi Ibukota Nusantara Menggunakan Algoritma Naïve Bayes dan KNN
Authors: Syahril Dwi Prasetyo  , Shofa Shofiah Hilabi  , Fitri Nurapriani  
Published: February 2023

Pemindahan serta pembangunan Ibu Kota Negara Nusantara pada masa Presiden Bapak Ir. H. Joko Widodo akan direlokasi secara bertahap dari tahun 2024 hingga 2045. Dengan hal ini tersebut maka menjadi sebuah perbincangan dan mengundang banyak reaksi, terutama bagi masyarakat Indonesia. Persoalan dalam Pemindahann Ibu Kota Negara merupakan hal yang sensitif sehingga ramai diperbincangkan di media sosial termasuk Twitter. Pada dasarnya media sosial digunakan untuk menyampaikan pendapat atau sebuah ekspresi. Pemanfaatan media sosial ini tentunya menjadi layanan dan fasilitas yang dapat dimanfaatkan untuk sebuah isu politik atau hal-hal yang sedang dibahas. Maka dari itu penelitian ini bertujuan untuk melakukan analisis sentimen masyarakat Indonesia terhadap pemindahan Ibu Kota Nusantara. Dalam penelitian ini metode yang digunakan adalah Naïve Bayes (NB) dan K-Nearest Neighbor (KNN). Hasil penelitian menyajikan hasil komparasi kinerja metode tersebut bahwa metode Naïve Bayes memberikan tingkat akurasi analisis sentimen sebesar 82.27%, nilai Precision sebesar 86.36% dan nilai Recall sebesar 76.93%. Kinerja metode KNN juga menyajikan hasil analisis dengan tingkat akurasi sebesar 88,12%, Precision sebesar 93.%98 dan nilai recall sebesar 81.53%. Berdasarkan hasil analisis tersebut maka proses analisis menggunakan metode KKN mengungguli metode NB dalam mengukur sentimen terhadap pemindahan Ibu Kota Nusantara.
ANALISIS STRUKTUR BIAYA DAN PEMASARAN USAHATANI JAGUNG MANIS (Zea mays L. Saccharata )
Authors: Wahyuni MS Etty , Afriani Noor 
Published: February 2023

AbstractSweet corn commodity has good prospects for development, but there are various problems in the sweet corn farming agribusiness system, namely the weak linkages between upstream to downstream subsystems such as distribution and supply of production factors, agricultural production processes, processing and marketing as well as risks to income. This study aims to analyze the cost structure, marketing channels and marketing efficiency of Sweet Corn (Zea mays L. Saccharata) in Tarakan City. Respondents obtained by purposive sampling method from sweet corn farmers in Tarakan City amounted to 112 people. Data analysis to answer existing problems includes analysis of cost structure, marketing channels, marketing margins, farmer's share and marketing efficiency. The results showed that variable costs gave the highest contribution to total production costs of 61.39% compared to fixed costs of 38.61%, with the highest percentage being labor costs. The marketing channel consists of 2 marketing channels, namely marketing channels that involve 1 marketing agency, namely market traders to consumers and marketing channels that involve 2 marketing institutions, namely collectors and market traders. Marketing channels 1 and 2 are in the efficient category based on the farmer's share value, namely 82% for channel 1 and 72% for channel 2.Key words: the cost structure, marketing, sweet corn AbstrakKomoditas jagung manis memiliki prospek yang baik untuk dikembangkan, namun terdapat berbagai permasalahan dalam sistem agribisnis usahatani jagung manis yaitu lemahnya keterkaitan antar subsistem hulu sampai ke hilir seperti distribusi dan penyediaan faktor produksi, proses produksi pertanian, pengolahan dan pemasaran serta risiko pada pendapatan. Penelitian ini bertujuan untuk menganalisis struktur biaya, saluran pemasaran dan efisiensi pemasaran Jagung Manis (Zea mays L. Saccharata) di Kota Tarakan. Responden diperoleh berdasarkan metode purposive sampling dari para petani jagung manis di Kota Tarakan berjumlah 112 orang. Analisis data untuk menjawab permasalahan yang ada meliputi analisis struktur biaya, saluran pemasaran, margin pemasaran, farmer’s sharedan efisensi pemasaran. Hasil penelitian menunjukkan biaya variabel memberi kontribusi tertinggi terhadap total biaya produksi sebesar 61,39% dibandingkan biaya tetap sebesar 38,61%, dengan persentase tertinggi adalah biaya tenaga kerja dan biaya pupuk. Adapun saluran pemasaran terdiri dari 2 saluran pemasaran yaitu saluran pemasaran yang melibatkan 1 lembaga pemasaran yaitu pedagang pasar ke konsumen dan saluran pemasaran yang melibatkan 2 lembaga pemasaran yaitu pengepul dan pedagang pasar. Saluran pemasaran 1 dan 2 termasuk kategori efisien berdasarkan nilai farmer’s share yaitu 82% untuk saluran 1 dan 72% untuk saluran ke 2.Kata kunci: struktur biaya, pemasaran, jagung manis
Kontribusi Madrasah Dalam Penerapan Konsep Akhlak Modern Di Era Disrupsi
Authors: Madjid Yuan Nisa , Qomariyah Lailatul , Khalidi Ahmad , Deviana Ade Destri 
Published: February 2023

<p><em>Lulusan madrasah dianggap belum mampu bersaing dalam kancah dunia khususnya pada bidang non Islamic studies seperti sains, kesehatan, dan teknik informatika, sebab penerapan pendidikan akhlak hanya berfokus pada akhlak secara tekstual tanpa diiringi akhlak untuk mengembangkan potensi diri dan keberlangsungan hidup. Akhlak modern (inovatif, produktif dan kreatif) menjadi konsep penting untuk solusi tersebut dan diterapkan dalam pendidikan madrasah melalui kegiatan pembelajaran dan life skill. Tujuan penelitian adalah untuk mengetahui konstribusi madrasah MTsN 4 Hulu Sungai Utara dalam penerapan akhlak modern. Penelitian ini menggunakan pendekatan kualitatif dengan library research. Hasil penelitian adalah konstribusi madrasah MTsN 4 Hulu Sungai Utara untuk menanamkan akhlak modern dilakukan melalui: 1) kegiatan ekstrakurikuler yang berpusat pada pengembangan life skill dan kewirausahaan, crafting, Teknologi Informatika (pengembangan software maupun aplikasi), inovasi barang dengan kreatifitas budaya lokal, pengolahan sampah, sains dan robotik, serta optimalisasi organisasi di madrasah; 2) metode pembejaran berbasis pemecahan masalah maupun menciptakan solusi berupa peluang dan usaha; 3) seminar dan pelatihan life skill yang bersifat modern dengan pembicara yang mampu mendobrak pasar nasional maupun internasional.</em></p>
Analisis Penggunaan Model Pembelajaran Kolaboratif Tipe Buzz Group Dalam Peningkatan Keaktifan Siswa SD
Authors: Maulidiya Maulidiya , Martati Badruli , Putra Deni Adi 
Published: February 2023

<p><em>Penelitian ini bertujuan untuk mendeskripsikan penggunaan metode pembelajaran kolaboratif tipe buzz group</em> <em>dalam hal peningkatan keaktifan siswa SD</em><em> salah satunya pada mata pelajaran PPKn yang cenderung kurang disukai oleh siswa SD, kajian pada artikel ini berfokuskan pada keaktifan siswa SD terhadap pelajaran PPKn menggunakan model pembelajaran kolaboratif tipe buzz group. Penelitian menggunakan metode diskriptif kualitatif. subjek yang digunakan dalam penelitian ini adalah siswa kelas 3 SD Muhammadiyah Surabaya. sumber data terdiri dari hasil wawancara dengan guru menggunakan lembar wawancara guru, dan dokumentasi. Analisis data dalam penelitian adalah pengumpulan data, reduksi data, penyajian data, dan kesimpulan. Dalam proses pembelajaran siswa cenderung kurang tertarik dan bosan dengan proses pembelajaran karena meode yang digunakan hanya ceramah dan monoton. Hasil penelitian ini adalah untuk mendeskripsikan keaktifan siswa sd terhadap pelajaran PPKn menggunakan model pembelajaran kolaboratif tipe buzz group. Sehingga peneliti melakukan penelitian ini agar siswa lebih aktif dalam proses pembelajaran. Keaktifan siswa sangat berperan penting dalam proses pembelajaran dan hasil belajar. </em></p>
Edukasi Kendalikan Tekanan Darah dengan Menerapkan Gaya Hidup Sehat di RW 11 Kelurahan Sukamentri Garut
Authors: Sumarni Nina , Rosidin Udin , Sumarna Umar , Shalahhudin Iwan , R Ema Arum , Noor Rohmahallia M 
Published: February 2023

Abstrak: Faktor-faktor penyebab tekanan darah tinggi diantaranya umur, jenis kelamin, keturunan, merokok, asupan garam berlebih, konsumsi lemak, minyak goreng bekas, kebiasaan minum alkohol, berat badan berlebih, aktivitas fisik kurang, stres dan penggunaan estrogen. Semua ini terkait dengan gaya hidup yang tidak sehat. Faktor resiko tersebut dapat dihindari dengan melakukan upaya-upaya preventif diantaranya dengan menerapkan pola hidup sehat, seperti minum obat rutin dan kontrol tekanan darah. Melalui pengendalian gaya hidup sehat adalah satu modalitas penting untuk mengontrol penyakit hipertensi. Tujuan dari kegiatan ini adalah peningkatan pengetahuan masyarakat tentang kendalikan tekanan darah dengan menerapkan gaya hidup sehat di RW 11 Kelurahan Garut. Metode yang digunakan untuk mencapai tujuan tersebut adalah melakukan kegiatan pendidikan kesehatan kepada masyarakat RW 11 Kelurahan Sukamentri Garut baik yang menderita tekanan darah tinggi maupun yang tidak. Hasil kegiatan menunjukkan terjadi peningkatan pengetahuan masyarakat RW 11 Kelurahan Sukamentri Garut sebelum dan sesudah dilaksanakan pendidikan kesehatan sebesar 22 point. Nilai pengetahuan sebelum pendidikan kesehatan terkecil 31 dan terbesar 78 dan nilai pengetahuan setelah dilaksanakan pendidikan kesehatan terkecil 79 dan terbesar 100. Dengan meningkatnya pengetahuan masyarakat tentang gaya hidup sehat mampu kendalikan tekanan darah.Abstract: Factors that cause high blood pressure include age, gender, family history, smoking, excess salt intake, saturated fat, used cooking oil, alcohol drinking habits, excess weight, lack of physical activity, stress and use of estrogen. Unhealthy lifestyle. These risk factors can be avoided by taking preventive measures, including by implementing a healthy lifestyle, such as taking regular medication and controlling blood pressure. Through controlling a healthy lifestyle, is an important modality to control hypertension. The purpose of this activity is to increase public knowledge about Controlling Blood Pressure by Implementing a Healthy Lifestyle in RW 11 Sukamentri, Garut. The method used to achieve this goal is to conduct health education activities for the community of Rw 11 Sukamentri, both those who suffer from high blood pressure and those who do not. The results of the activity showed that there was an increase in the knowledge of the people of Rw 11 Sukamentri Village before and after health education was carried out by 22 points. The smallest value of knowledge before health education is 31 and the largest is 78 and the smallest value of knowledge after health education is 79 and the largest is 100. With increasing public knowledge about a healthy lifestyle, they are able to control blood pressure.