bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulse design for joint optimization of semisolid saturation and free water rotation
Authors: Leitão David , Tomi-Tricot Raphael , Bridgen Pip , Wilkinson Tom , Liebig Patrick , Gumbrecht Rene , Ritter Dieter , Giles Sharon , Baburamani Ana , Hajnal Joseph , Malik Shaihan 
Published: August 2023

In MT imaging, particularly at ultra-high field, results can be influenced by spatial variations in both (1) on-resonance flip angle and (2) RF saturation specified by B1rms including on- and off-resonance contributions. Conventional pulse design with parallel transmission focuses on homogenizing flip angle (&alpha;) distributions but does not explicitly account for B1rms distribution.
In this work we propose a generalized pulse design framework that considers both &alpha; and B1rms and apply it to achieve uniform excitation and saturation at the same time. Performance is confirmed in phantom experiments at 7T, resulting in more uniform MTR compared to conventionally-designed pulses.
Beyond the Surface: The Psychosocial Effects of Atopic Dermatitis
Authors: Mudd Kara 
Published: August 2023

Purpose The purpose of this article is to review the psychosocial effects of atopic dermatitis. It is important for providers to identify the psychosocial comorbidities associated with atopic dermatitis to provide well rounded patient care. Method A PubMed literature search was conducted with search terms “atopic dermatitis,” “psychosocial,” and “comorbidities.” Filters were set to articles published after 2015 and limited to clinical and systematic reviews, meta-analysis, and clinical trials. This yielded nine articles. A second search was performed using the terms “atopic dermatitis,” “anxiety,” and “depression” with similar parameters and 41 studies were revealed. Additional searches were performed in Medline and the Cochrane library with the same key terms. Results Several quality studies showed that atopic dermatitis is associated with increased risk of anxiety, depression, attention deficit hyperactivity disorder, suicidality, and decreased quality of life. Additional research is needed to determine the relationship between atopic dermatitis and obsessive-compulsive disorder, and schizophrenia. Many studies proposed pruritus and sleep deprivation as primary factors in increasing mental health comorbidities of atopic dermatitis. Conclusion Dermatology providers should screen for associated comorbidities of atopic dermatitis and refer for appropriate treatment as necessary. Aggressive treatment of atopic dermatitis can improve overall quality of life and subsequently lessen the rate of associated comorbidities.
A Survey of Nurse Practitioner and Physician Assistant Advanced Practice Providers Uncovers a Need for Precision Medicine in Psoriasis Management
Authors: Harkiewicz Adam , Martin George , Dickerson Tobin J. , Deren-Lewis Ann 
Published: August 2023

Objective The arrival of biologics has considerably improved the treatment of psoriasis and psoriatic arthritis; however, it can be difficult to identify which biologic(s) a patient will respond to without undergoing a trial-and-error approach. The current survey was designed to investigate biologic switching in the clinic and whether a biomarker test would assist in selecting the appropriate treatment for patients and improve psoriasis management. Methods A survey of 157 nurse practitioner and physician assistant (NP/PA) advanced practice providers was conducted to assess (1) the frequency of biologic switching and (2) the perceived clinical utility of a biomarker test that stratifies psoriasis patients to predict biologic response. Results More than half of advanced practice providers (55%) indicated that psoriasis patients require at least two different biologics to achieve an adequate response to treatment, with 59% of respondents specifying that 10% to 30% of their patients switch biologics the first year of treatment. Ninety-six percent of respondents indicated that a biomarker test would likely improve their practice, with the majority of participants (84%) suggesting a biomarker test could improve their ability to determine the most appropriate therapy for their patients. Ninety-one percent indicated they would use a biomarker test (Mind.Px, Mindera Health, San Diego, California), and 63% said they would perform the test in their office. Conclusions A biomarker test may help shift psoriasis management from a trial-and-error approach to precision care, thereby reducing the time to effective treatment and improving patient outcomes.
Developing Website for Belimbing Tourism Village, Tabanan, Bali
Authors: Dewi Ni Wayan Sintya , Sutama I Ketut , Murni Ni Gst Nym Suci , Sudiarta Made 
Published: August 2023

Purpose: The purpose of this research is to evaluate the Belimbing Village website in development efforts website by model information, communication, transaction, relationship and techical-merit (ICTRT) carried out to support the Belimbing Tourism Village produces dimensions of effectiveness website the maximum in helping the promotion of Belimbing Tabanan Tourism Village.
Research methods: The data collection methods used were observation, interviews, questionnaires and interviews. In this study using qualitative and quantitative approaches or better known as mixed method research by using SWOT analysis techniques and Importance Performance Analysis.
Findings: The results of the research using the interview method show that the application website in Belimbing Village is still very minimal because there are many features and items that need to be developed, one of which is the information dimension, transaction dimension and communication dimension. The results of the study using SWOT analysis showed that Belimbing Village has utilized ICT, but even though it has implemented ICT there are still many aspects that are lacking in website, so that more in-depth research is needed to assess its effectiveness in website Belimbing Village. Based on analysis Importance Performance Analysis produce effectiveness attributes. The researcher adopted the ICTRT model which consisted of 47 evaluation instruments which were divided into 5 evaluation dimensions.
Implication: Site evaluation website expected to maximize promotion through website in Belimbing Village because website is an effective solution to introduce and market products/services by utilizing the internet as an information medium.
Green Tourism-Based Food and Beverage Service to Increase Customer Satisfaction at Four Points By Sheraton Bali Kuta
Authors: Agustini Ni Kadek , Sudiarta Made , Elistyawati Ida Ayu , Winia I Nyoman , Suparta I Ketut 
Published: August 2023

Purpose: This study to determine the application of green tourism based service by the food and beverage service department at Four Points By Sheraton Bali Kuta and how it impact on customer satisfaction.
Research methods: The research sample was determined by the incidental sampling method with a sampe of 80 guest who had received service from the food and beverage service department at Four Points By Sheraton Bali Kuta as respondents. The data collection method used in a questionnaire. The data analysis technique is descriptive qualitative analysis with descriptive statistics on a likert scale range using microsoft excel 2010.
Findings: The results show that the application of green tourism-based services on green service and energy-saving variables according to customers is not good. The variables of green product, green design and consumption reduction according to customers are good.
Implications: The impact of green tourism-based services on customer satisfaction at The Eatery Restaurant is that customers agree to take actions such as buying back products and services, recommending products and services to others, buying other types of products from The Eatery Restaurant, being interested in buying food and beverage products from The Eatery Restaurant.
Peran Masyarakat Dalam Penegakan Hukum di Indonesia
Authors: Aaron Alelxander  
Published: August 2023

Penegakan hukum merupakan sarana efektif untuk mencapai tujuan hukum. Karena itu sudah semestinya seluruh tenaga dikerahkan agar hukum mampu bekerja untuk mewujudkan nilai-nilai moral dalam hukum. Dalam konteks penegakan hukum di Indonesia, maka peran aktif masyarakat tentunya tidak mungkin dapat dipisahkan. Di Indonesia sendiri masyarakat memiliki peran penting dalam setiap upaya yang dilakukan oleh negara untuk menegakan hukum. Penelitian ini menggunakan metode tinjauan literature (library research) yaitu penelitian yang didasarkan pada pendapatan-pendapat ahli. Hasil penelitian ini menunjukan, bahwa masyarakat juga merupakan bagaian terpenting dalam sebuah negara, karena masyarakat memiliki peran untuk pemeliharaan dan dukungan untuk mencapai tujuan dari suatu negara. Untuk mengupayakan adanya penegakan hukum yang berkeadilan di Indonesia, sangat diperlukan kepekaan dan keaktifan masyarakat dalam menghargai hak yang dimiliki oleh setiap orang, meningkatkan etika dan moral dengan kesadaran sendiri, serta menunaikan kewajiban dalam bermasyarakat. Partisipasi masyarakat merupakan unsur penting dalam perlindugan dan penegakan hukum. Masyarakat yang aktif dapat membantu menghilangkan kemungkinan terjadinya pengabaian terhadap kasus hukum. Peran masyarakat dalam penegakan hukum di Indonesia dapat dilakukan dengan dua Jalan, yaitu pengawasan aktif masyarakat harus dalam perlindungan dan control terhadap penegakan hukum. Bentuk partisipasi warga negara dalam perlindungan dan penegakan hukum didalam lingkungan sekitarnya bisa berupa masyarakat aktif dalam melaporkan dugaan tindakan kriminal yang ada disekitarnya.
Teknik Pengumpulan Data Dan Instrumen Penelitian Ilmiah Pendidikan Pada Pendekatan Kualitatif dan Kuantitatif
Authors: Ardiansyah  , Risnita  , Jailani M. Syahran 
Published: August 2023

Berhasil atau tidaknya suatu penelitian ilmiah pendidikan tidak lepas dari teknik pengumpulan data dan instumen penelitian yang digunakan. Tujuan makalah ini adalah untuk membahas tentang teknik pengumpulan data dan instrumen penelitian ilmiah pendidikan pada pendekatan kualitatif dan kuantitatif. Makalah ini menggunakan pendekatan studi kepustakaan, dimana penulis mengumpulkan referensi berupa buku dan jurnal yang berkaitan dengan tema dalam makalah ini. Hasil makalah ini dapat diuraikan bahwa dalam penelitian kualitatif, teknik pengumpulan data yang umum digunakan antara lain wawancara, observasi, dan dokumentasi, wawancara melibatkan interaksi langsung antara peneliti dan responden untuk mendapatkan data berupa pandangan, pengalaman, dan persepsi mereka, observasi melibatkan pengamatan langsung terhadap subjek penelitian, studi dokumentasi melibatkan pengumpulan data dari dokumen, arsip, atau bahan tertulis lainnya. Sementara itu, dalam penelitian kuantitatif, teknik pengumpulan data yang umum digunakan adalah angket atau kuesioner, observasi terstruktur, eksperimen, angket atau kuesioner digunakan untuk mengumpulkan data melalui pertanyaan yang telah disusun sebelumnya, observasi terstruktur melibatkan pengamatan yang telah dirancang sebelumnya dengan variabel-variabel yang telah ditentukan, eksperimen melibatkan manipulasi variabel-variabel tertentu untuk melihat dampaknya terhadap variabel lainnya. Instrumen penelitian dalam penelitian kualitatif meliputi panduan wawancara, daftar periksa observasi, pedoman dokumentasi, sedangkan dalam penelitian kuantitatif, instrumen penelitian meliputi angket atau kuesioner, daftar periksa observasi terstruktur, instrumen pengukuran dalam eksperimen.
Prevalence of bone loss surrounding dental implants as detected in cone beam computed tomography: a cross-sectional study
Authors: Algahtani Fahda N. , Hebbal Mamata , Alqarni Moath M. , Alaamer Rahaf , Alqahtani Anwar , Almohareb Rahaf A. , Barakat Reem , Abdlhafeez Manal M. 
Published: August 2023

Objectives
The objective of this study was to assess the prevalence of crestal, and apical bone loss (CBL & ABL) associated with dental implants in CBCT scans. The second objective was to assess the radiographic stage of implant disease and the visible predisposing factors.

Materials and Methods
The CBCT scans that were taken from January 2015 to January 2022 in King Saud Medical City were screened to examine the marginal and periapical condition of dental implants. Information related to demographic variables, stage of bone loss, and radiographically evident predisposing factors were collected. The results were analyzed using descriptive statistics, chi-square test, and logistic regression analysis.

Results
In total, 772 implant scans were analyzed. The prevalence of crestal bone loss and apical bone loss around the implants were 6.9% and 0.4% respectively. The amount of bone loss was moderate in 52.8% of cases of CBL and 100% mild in cases of ABL. The risk factors for CBL were patient age (p < 0.001), implant location (p < 0.001), bone loss in proximal teeth (p < 0.001), and adjacent edentulous sites (p < 0.001). The risk factors for ABL were adjacent periapical infection (p < 0.001) and endodontic therapy (p = 0.024).

Conclusion
The prevalence of CBL and ABL was low. The CBCT can be used as a diagnostic tool for studying the prevalence of bone loss associated with peri-implant disease and relevant risk factors. The implantation of CBCT to evaluate the success and the prognosis of dental implants or the treatment of peri-implant diseases can be further considered in future research.
Nitrogen Management through Nano Urea and Conventional Urea and its Effect on Wheat (Triticum aestivum L.) Growth and Yield
Authors: Singh Divya , Yadav Atish , Tiwari Himanshu , Singh Anil Kumar , Singh Shivendra , Yadav Rishi Kumar , Gangwar Parthik , Sachan Dhruvendra Singh 
Published: August 2023

The field experiment was carried out at Agronomy Research Farm of Acharya Narendra Dev University of Agriculture and Technology, Kumarganj, Ayodhya (U.P.) during Rabi Season 2021-22 to study the “Study on performance of nitrogen management through nano urea and conventional urea in wheat (Triticum aestivum L.)” The experiment was laid out in Randomized Block Design with four replications and six treatments i.e. T1: Control, T2 : 100% recommended dose of nitrogen (RDN) through conventional Urea (40% at Basal+ 30% at 30days after sowing (DAS)+30% at 50DAS), T3 : 75% RDN through conventional Urea as Basal + 25% RDN through Nano Urea as Topdressing (at 30 and 50 DAS), T4 : 50% RDN through conventional Urea as Basal + 50% RDN through Nano Urea as Topdressing (at 30 and 50 DAS), T5 : 25% RDN through conventional Urea as Basal + 75% RDN through Nano Urea as Topdressing (at 30 and 50 DAS), T6 : 100% RDN through Nano Urea as Topdressing (50% at 30DAS+50% at 50DAS). The observation on different growth and yield parameters were recorded and analyzed statistically. The experimental results revealed that among the treatments, treatment T4 recorded highest plant height, number of tillers m-2, leaf area index, dry matter accumulation, number of spikes m-2, length of spike, grains spike-1, yield and nutrient uptake. The highest net returns (₹ 51286 ha-1) and B:C ratio (1.42) were noticed by the application of T4 (50% RDN through conventional Urea as Basal + 50% RDN through Nano Urea as Topdressing (at 30 and 50 DAS). From this study, it can be concluded that T4 (50% RDN through conventional Urea as Basal + 50% RDN through Nano Urea as Topdressing (at 30 and 50 DAS) found most economical over other treatments, it gave more net returns.
Association of Pregnancy-Specific Alcohol Policies With Infant Morbidities and Maltreatment
Authors: Roberts Sarah C. M. , Schulte Alex , Zaugg Claudia , Leslie Douglas L. , Corr Tammy E. , Liu Guodong 
Published: August 2023

ImportanceResearch has found associations of pregnancy-specific alcohol policies with increased low birth weight and preterm birth, but associations with other infant outcomes are unknown.ObjectiveTo examine the associations of pregnancy-specific alcohol policies with infant morbidities and maltreatment.Design, Setting, and ParticipantsThis retrospective cohort study used outcome data from Merative MarketScan, a national database of private insurance claims. The study cohort included individuals aged 25 to 50 years who gave birth to a singleton between 2006 and 2019 in the US, had been enrolled 1 year before and 1 year after delivery, and could be matched with an infant. Data were analyzed from August 2021 to April 2023.ExposuresNine state-level pregnancy-specific alcohol policies obtained from the National Institute on Alcohol Abuse and Alcoholism’s Alcohol Policy Information System.Main Outcomes and MeasuresThe primary outcomes were 1 or more infant injuries associated with maltreatment and infant morbidities associated with maternal alcohol consumption within the first year. Logistic regression, adjusting for individual-level and state-level controls, and fixed effects for state, year, state-specific time trends, and SEs clustered by state were used.ResultsA total of 1 432 979 birthing person–infant pairs were included (mean [SD] age of birthing people, 32.2 [4.2] years); 30 157 infants (2.1%) had injuries associated with maltreatment, and 44 461 (3.1%) infants had morbidities associated with alcohol use during pregnancy. The policies of Reporting Requirements for Assessment/Treatment (adjusted odds ratio [aOR], 1.28; 95% CI, 1.08-1.52) and Mandatory Warning Signs (aOR, 1.18; 95% CI, 1.10-1.27) were associated with increased odds of infant injuries but not morbidities. Priority Treatment for Pregnant Women Only was associated with decreased odds of infant injuries (aOR, 0.83; 95% CI, 0.76-0.90) but not infant morbidities. Civil Commitment was associated with increased odds of infant injuries (aOR, 1.26; 95% CI, 1.08-1.48) but decreased odds of infant morbidities (aOR, 0.57; 95% CI, 0.53-0.62). Priority Treatment for Pregnant Women and Women With Children was associated with increased odds of both infant injuries (aOR, 1.12; 95% CI, 1.00-1.25) and infant morbidities (aOR, 1.08; 95% CI, 1.03-1.13). Reporting Requirements for Child Protective Services, Reporting Requirements for Data, Child Abuse/Neglect, and Limits on Criminal Prosecution were not associated with infant injuries or morbidities.Conclusions and RelevanceIn this cohort study, most pregnancy-specific alcohol policies were not associated with decreased odds of infant injuries or morbidities. Policy makers should not assume that pregnancy-specific alcohol policies improve infant health.
Critical Appraisal of Guideline Recommendations on Systemic Therapies for Advanced Hepatocellular Carcinoma
Authors: Cappuyns Sarah , Corbett Virginia , Yarchoan Mark , Finn Richard S. , Llovet Josep M. 
Published: August 2023

ImportanceThe combination of immune checkpoint inhibitors with antiangiogenic agents has revolutionized the treatment landscape of advanced hepatocellular carcinoma (HCC). However, due to rapid publication of new studies that attained their predefined primary end points, a lack of robust cross-trial comparison of first-line therapies, and diverging clinical guidelines, no clear-cut treatment flowchart and sequence of therapies are available. This critical analysis of the recommendations for the management of advanced HCC from the main scientific societies in the US and Europe adopted an integrated approach to provide information on the clinical benefit (overall survival and progression-free survival) and safety profile of these therapies using the European Society for Medical Oncology (ESMO)–Magnitude of Clinical Benefit Scale (MCBS) score and an ad hoc network meta-analysis.ObservationsThere is a major consensus among guidelines that atezolizumab plus bevacizumab has a primacy as the recommended first-line treatment of choice in advanced HCC. On progression after immunotherapy-containing regimens and for patients with contraindications for immunotherapies, most guidelines maintain the established treatment hierarchy, recommending lenvatinib or sorafenib as the preferred options, followed by either regorafenib, cabozantinib, or ramucirumab. Thus far, the first-line immune-based regimen of tremelimumab plus durvalumab has been integrated only in the American Association for the Study of Liver Diseases guidance document and the latest National Comprehensive Cancer Network guidelines and has particular utility for patients with a high risk of gastrointestinal bleeding. Overall, in the first-line setting, both atezolizumab plus bevacizumab and sintilimab plus IBI305 (a bevacizumab biosimilar) and durvalumab plus tremelimumab received the highest ESMO-MCBS score of 5, indicating a substantial magnitude of clinical benefit. In a network meta-analysis, no significant differences in overall survival were found among the various combination regimens. However, the newly reported combination of camrelizumab plus rivoceranib was associated with a significantly higher risk of treatment-related adverse events compared with atezolizumab plus bevacizumab (relative risk, 1.59; 95% CI, 1.25-2.03; P &amp;lt; .001).Conclusions and RelevanceThis narrative review found that atezolizumab plus bevacizumab is regarded as the primary standard of care for advanced HCC in the first-line setting. These findings from integrating the recommendations from scientific societies’ guidelines for managing advanced HCC along with new data from cross-trial comparisons may aid clinicians in decision-making and guide them through a rapidly evolving and complex treatment landscape.
Carbon Nanotube‐Directed 7 GPa Heterocyclic Aramid Fiber and Its Application in Artificial Muscles
Authors: Yan Dan , Luo Jiajun , Wang Shijun , Han Xiaocang , Lei Xudong , Jiao Kun , Wu Xianqian , Qian Liu , Zhang Xinshi , Zhao Xiaoxu , Di Jiangtao , Zhang Zhong , Gao Zhenfei , Zhang Jin 
Published: August 2023

AbstractPoly(p‐phenylene‐benzimidazole‐terephthalamide) (PBIA) fibers with excellent mechanical properties are widely used in fields that require impact‐resistant materials such as ballistic protection and aerospace. The introduction of heterocycles in polymer chains increases their flexibility and makes it easier to optimize the fiber structure. However, the inadequate orientation of polymer chains is one of the main reasons for the large difference between the measured and theoretical mechanical properties of PBIA fibers. Herein, carbon nanotubes (CNTs) are selected as an orientation seed. Their structural features allow CNTs to orient during the spinning process, which can induce an orderly arrangement of polymers and improve the orientation of the fiber microstructure. To ensure the complete 1D topology of long CNTs (≈10 µm), PBIA is used as an efficient dispersant to overcome dispersion challenges. The p‐CNT/PBIA fibers (10 µm single‐walled carbon nanotube 0.025 wt%) exhibit an increase of 22% in tensile strength and 23% in elongation, with a maximum tensile strength of 7.01 ± 0.31 GPa and a reinforcement efficiency of 893.6. The artificial muscle fabricated using CNT/PBIA fibers exhibits a 34.8% contraction and a 25% lifting of a 2 kg dumbbell, providing a promising paradigm for high‐performance organic fibers as high‐load smart actuators.