bluuebunny/crossref_metadata_2025_split huggingface dataset:
A literature review: developing an information feedback interface to encourage water conservation behavior among utility customers
Authors: Hawkins Chelsea A.J. , Berthold T. Allen 
Published: March 2023

Water conservation behavior among water utility customers can be encouraged by engaging and educating customers about their consumption habits. To be successful, the information used to engage and educate must (1) be comprehensive, including both broad and narrow information, so that individuals understand where they fit into water management and how their actions impact water management and their community, and (2) help them make decisions about their use.
This article is a literature review of elements that can be incorporated into a customer-friendly information feedback interface. Some elements discussed are billing features, information about the water cycle, and local water sources, and local partnerships. The use of data is also addressed, and to that end, benefits of advanced metering infrastructure systems are mentioned. The details of these systems are not addressed. The intent of this research is to provide types and styles of information that can be combined to create an effective and meaningful information feedback system for water utility customers to encourage conservation.
Citation: Hawkins CAJ, Berthold TA. 2016. A literature review: developing an information feedback interface to encourage water conservation behavior among utility customers. Texas Water Journal. 7(1):40-55. Available from: https://doi.org/10.21423/twj.v7i1.7029.
Rhythmological features of the nasal mucociliary system functioning in healthy children and children with bronchial asthma
Authors: Golikova E. V. , Kondratyeva E. I. , Shemyakina T. A. , Krivonogova T. S. , Tyuteva E. Yu. , Zhelev V. A. , Solnyshko A. L. 
Published: March 2023

Introduction. The circadian rhythms of the nasociliary system of children with bronchial asthma have not been practically studied.Objective. To evaluate seasonal variations of circa-annual rhythms of the nasociliary system in healthy children and children with year-round bronchial asthma.Materials and methods. 134 children were examined; the main group consisted of 99 children aged 1.5–7 years with mild and moderate bronchial asthma, the control group was represented by 45 healthy children of the same age. The biorhythms of the nasociliary system were studied for three years, 4 times during each year (in October, January, April, July): smears-prints from the nasal mucosa were studied with the calculation of the specific gravity of neutrophils, eosinophils, cylindrical and squamous epithelium as a percentage, the calculation of the cytolysis index of cells and the average destruction index for each type of cell. To study the near-seasonal rhythms, the KOSINOR program and the computer system of intra-laboratory control “VlCC” were used.Results. The presence of seasonal changes in cytological parameters of the nasal mucosa with the maximum values of the average values of the average destruction of the flat, cylindrical epithelium, neutrophils in January and acrophases in January was revealed. If eosinophils on the nasal mucosa were not detected in healthy children, then the presence of this type of cells was noted in children with asthma throughout the year. The period of fluctuations of the average destruction index in the flat epithelium (1.7 months) was 4 times shorter, and in the cylindrical epithelium (21.6 months) – 3.5 times longer in children with asthma compared with healthy children. The periods, amplitude and mesor of the average neutrophil destruction index in children with asthma and healthy peers did not differ significantly. Acrophases and bathyphases of the average index of destruction of the flat, cylindrical epithelium, neutrophils in patients with asthma and healthy children were recorded at different times.Conclusions. The study showed that in children with AD there are no patterns of rhythmological organization in the work of the nasociliary system, characteristic of healthy children.
G-1082A IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus
Authors: Popadyuk V. I. , Kastyro I. V. , Korshunova I. A. , Chernolev A. I. , Kirichenko I. M. , Mikhalskaia P. V. , Spirin E. A. , Gusev K. S. , Dubova V. V. , Dolgonovskaya A. S. , Shalamov K. P. 
Published: March 2023

Introduction. Adenoid hypertrophy (pharyngeal tonsil hypertrophy) is considered as one of the most common diseases of the ENT organs.Aim. To study the polymorphism of the IL-10 gene (interleukin 10) and infections caused by human herpesvirus 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with AH.Materials and methods. The study included 106 children with adenoid hypertrophy and 38 healthy children aged 2 to 11 years. All children with adenoid hypertrophy were divided into three subgroups depending on the size of the pharyngeal tonsil. Viruses were determined by real-time quantitative polymerase chain reaction (PCR).Results. In patients with AH, HHV6 was detected more often than in CMV and EBV. Among the three subgroups of children with HGM, HHV6 and EBV infections prevailed in children with the maximum degree of pharyngeal tonsil hypertrophy. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest size of the pharyngeal tonsil compared to other subgroups.Discussions. The frequencies of HHV-6 and CMV in the control group are significantly different. HHV-6 was the most frequently detected virus in patients with HGM compared with CMV and EBV. The frequency of the GG genotype was in the control group of children. A significantly higher frequency of the G allele and GG genotypes was found in the first subgroup of children compared to the second and exclusive subgroups. We found a lower frequency of the G allele and GG and GA genotypes in a significant subgroup of children compared to the second subgroup. Previous studies show a significant increase in the frequency of the A allele and the AA and IL-10 genotypes (rs1800896-1082G/A) in patients resistant to HHV-6 and CMV infections compared to those infected.Conclusions. The presence of HHV-6 and CMV infections contributes to the development of pharyngeal tonsil hypertrophy, and HHV-6 and EBV may contribute to the size of the pharyngeal tonsil.
Quantitative assessment of structural changes in the cornea against the background of long-term wearing of contact lenses according to the results of confocal microscopy
Authors: Surnina Z. V. , Averich V. V. 
Published: March 2023

Introduction. The article presents an objective assessment of the morphofunctional status of the cornea during the long-term wear of soft contact lenses (SCLs). Aim. To assess the qualitative and quantitative changes in the cornea microstructure using the laser confocal microscopy during the long-term wear of SCLs, as well as combined tear replacement therapy based on formulations consisting of trehalose and hyaluronic acid. Materials and methods. The study included 62 patients (124 eyes) divided into three groups. The first two groups included 32 patients (64 eyes) with different degrees of myopia, using SCLs as an optical correction for 7–15 years (11 years on average): Group 1 included 15 patients (30 eyes) using tear replacement therapy in the form of a drug containing trehalose and hyaluronic acid twice a day for 3 months, Group 2 included 17 patients (34 eyes) who did not receive any tear replacement therapy. The laser corneal confocal microscopy was performed using Heidelberg Retinal Tomograph III followed by digital image processing aided by author software with the focus on the state of nerve fibers and dendritiform macrophages (Langerhans cells). Results and discussion. The laser corneal confocal microscopy with assessment of the structure of the corneal nerve fibers and Langerhans cells can be used for the dynamic monitoring of the state of the anterior segment of the eye in SCL users. When pathological changes are detected, a patient may be recommended the corneotrophic therapy and (or) switching to another type of contact lenses. Conclusion. The use of tear replacement medications containing trehalose and hyaluronic acid improves the subjective tolerance of SCLs and also makes it possible to significantly reduce the severity of epitheliopathy in patients, who use SCLs as optical correction for a long time.
Severe acute bronchiolitis in children: etiology, therapy, effectiveness of 3% hypertonic saline containing sodium hyaluronate
Authors: Tsygankov A. E. , Ovsyannikov D. Yu. , Ivanova A. G. , Solodovnikova O. N. , Gosteva O. M. , Dyagileva A. Yu. , Nosov S. A. , Nikolishin A. N. , Gorev V. V. 
Published: March 2023

Introduction. Acute bronchiolitis (АB) is a common infection in children under the age of 2 years. In modern clinical protocols, routine use of the studied drugs is not recommended. The effectiveness of a 3% hypertonic sodium chloride solution (HSCS) at vol.Аim. Тo study the etiology, risk factors, the therapy of acute care in children in intensive care units (ICU), the effectiveness of inhalations with 3% HSCS with hyaluronate sodium (HS) in comparison with therapy without the inclusion of this drug.Materials and methods. The medical documentation of 54 patients with AB from January 2021 to January 2023 who were treated in the ICU was analyzed. An ambispective comparative study of the effectiveness of therapy of 3% HSCS with HS AB was conducted in comparison with historical control.Results. Respiratory syncytial viral (RSV) etiology was established in 50% of patients. The most common risk factor for the disease was the age younger than 3 months (40.7%). The presence of risk factors for severe course of acute respiratory failure had an impact on the average bed-day and on the need for respiratory support (p = 0.04), in addition to which patients often received drug therapy. There were no statistically significant differences in the terms of hospitalization, the duration of respiratory support depending on the appointment of 3% of HSCS with HS (p > 0.05), however, there was an improvement in clinical and functional dynamics estimated by the modified clinical scale of Wood’s asthma by the 2nd day of the disease.Conclusion. AB in ICU patients most often has RSV etiology, developing in the presence of risk factors for severe course. The influence of modern guidelines for the treatment of AB in the ICU remains controversial. The addition of 3% HSCS with HS can improve the flow of AB.
International literature characteristics and hotspots evolution of the impact of climate change on cotton: A bibliographic study
Authors: Li Na , Liang Jiaping , Yang Qiliang , Du Tianmu 
Published: March 2023

Abstract
This study uses information visualization analysis software to quantitatively analyze the literature characteristics and hotspot evolution in the field of research on the impact of climate change on cotton. The results showed that the number of literature was on the rise, and environmental sciences, agronomy, plant sciences, water resources and agriculture were the main disciplines in this field. Countries and regions such as China, the U.S.A, Argentina, Pakistan and India pay great attention to the research field, and the cooperation between countries was relatively closed. Many well-known institutions such as the Chinese Academy of Sciences, University of Agriculture Faisalabad, Nanjing Agricultural University and United States Department of Agriculture-Agricultural Research Service were committed to research in this field. ‘Yield’, ‘CO2’, ‘Adaptation strategy’, ‘Irrigation’, ‘Model’, etc., were the hot words in the research. Research hotspots had developed from the research on assessing the impact of climate change on future cotton production to focus on the impact of CO2 concentration on cotton production, coping strategies for cotton industry development under climate change and climate-smart agriculture issues.
The Value of Emerging Prostate Cancer-associated lncRNA PCGEM1 in
Various Tumors
Authors: Lv Xing , Zhang Mingzhu , Xu Wen 
Published: March 2023

Background:
LncRNA not only plays an auxiliary role as an intermediate carrier of genetic
information, but also mediates various regulatory functions. The complex and precise regulatory function
of lncRNA in development and gene expression has greatly explained the complexity of the genome,
and also opened a new avenue for people to understand the complexity of life from the dimension
of gene expression. Long non-coding RNA (lncRNA) prostate cancer gene expression marker 1
(PCGEM1) is a characterized oncogenic lncRNA in different cancers. This review is dedicated to
summarizing the various molecular mechanisms of PCGEM1 and demonstrates that the biological
functions exerted by PCGEM1 are good starting points for therapy.

Methods:
The molecular mechanism of PCGEM1 acting on tumors has been summarized by reviewing
the literature available on PubMed.

Results:
The expression of lncRNA PCGEM1 is abnormally increased in all kinds of tumors, including
cervical cancer, prostate cancer, renal carcinoma, gastric cancer, lung cancer, ovarian carcinoma,
cough variant asthma, and castration tolerant prostate cancer. Besides, PCGEM1 mediates multiple
processes involved in carcinogenesis, including proliferation, invasion, anti-apoptosis, and migration.

Conclusion:
The potential of PCGEM1 as a therapeutic target for cancer is revealed.
New Psychometric Strategies for the Evaluation of Affective, Cognitive,
and Psychosocial Functioning in Unipolar versus Bipolar Depression:
Impact of Drug Treatment
Authors: Guerrera Claudia Savia , Platania Giuseppe Alessio , Varrasi Simone , De Vivo Simona , Pirrone Concetta , Vezzosi Venera Francesca , Tascedda Fabio , Drago Filippo , Di Nuovo Santo , Blom Johanna M.C. , Castellano Sabrina , Caraci Filippo 
Published: March 2023

Background:
Different studies have been conducted to understand how patients with unipolar
and bipolar depression differ in terms of cognitive and affective symptoms as well as in psychosocial
function. Furthermore, the impact of antidepressants, second-generation antipsychotics, and mood
stabilizers on these dimensions needs to be characterized, as well as the best psychometric approach to
measure changes after pharmacological treatment.

Objectives:
This study aims to analyze the impact of psychotropic drugs on cognitive, affective, and
psychosocial functioning in MDD and BD patients; to test the sensitivity of psychometric tools for
measuring those changes; also, to understand how psychosocial abilities are associated with affective
and cognitive dimensions in patients with MDD and BD.

Methods:
A total of 22 patients with MDD and 21 patients with BD in the depressive phase were recruited.
Several psychometric tests were administered to assess affective, cognitive, and psychosocial symptoms
before and after 12 weeks of drug treatment (T0 and T1) with different psychotropic drugs including
second-generation antidepressants, second-generation antipsychotics and mood stabilizers (lamotrigine).

Results:
MDD patients showed significant improvement in MoCA, Delayed Recall of Rey’s 15 Words
and HDRS, while a significant worsening was detected on Digit Span Backwards and on FAST scores.
Instead, patients with BD showed significant improvements in the MoCA as the MDD patients, but only
a trend of improvement (non-statistically significant) on the BDI-II. A positive correlation was detected
in both groups between FAST and HDRS and BDI-II scores, especially in BD patients.

Conclusion:
Our results demonstrate that drug treatment with psychotropic drugs can improve cognitive
and affective symptoms, but not all psychometric tools may be equally sensitive to detect those
changes in MDD vs. BD patients. Moreover, we found that affective and cognitive dimensions can be
considered as different psychopathological dimensions both in unipolar and bipolar depression.
Pharmacological Progress of Mitophagy Regulation
Authors: Sehgal Sheikh Arslan , Wu Hao , Sajid Muhammad , Sohail Summar , Ahsan Muhammad , Parveen Gulnaz , Riaz Mehreen , Khan Muhammad Saleem , Iqbal Muhammad Nasir , Malik Abbeha 
Published: March 2023

Abstract:
With the advancement in novel drug discovery, biologically active compounds are considered
pharmacological tools to understand complex biological mechanisms and the identification of potent
therapeutic agents. Mitochondria boast a central role in different integral biological processes and mitochondrial
dysfunction is associated with multiple pathologies. It is, therefore, prudent to target mitochondrial
quality control mechanisms by using pharmacological approaches. However, there is a scarcity of
biologically active molecules, which can interact with mitochondria directly. Currently, the chemical
compounds used to induce mitophagy include oligomycin and antimycin A for impaired respiration and
acute dissipation of mitochondrial membrane potential by using CCCP/FCCP, the mitochondrial uncouplers.
These chemical probes alter the homeostasis of the mitochondria and limit our understanding of the
energy regulatory mechanisms. Efforts are underway to find molecules that can bring about selective removal
of defective mitochondria without compromising normal mitochondrial respiration. In this report,
we have tried to summarize and status of the recently reported modulators of mitophagy.
Recent Updates on the Management of Human Papillomavirus-related
Cancers
Authors: Karikalan Barani , Chakravarthi Srikumar 
Published: March 2023

Abstract:
Cervical cancer incidence and mortality rates have been steadily decreasing in developed
nations owing to the excellent screening programs executed. However, it still remains one of the
most prevalent tumors in developing nations, contributing significantly to cancer-related mortality in
females. The major causal factor in the genesis of cervical cancer is recognized to be human papillomavirus
(HPV) infection. The female population, particularly in poor countries, is highly susceptible
to HPV infections and cervical cancer as a result of the increasing costs posed by widespread
cervical screening and HPV vaccination methods. Understanding the roles of HPV oncoproteins (E6
and E7) and non-coding RNAs, along with their many cellular targets, can help us develop targeted
drug therapy to manage cervical cancer. In the hunt for novel ways for effective disease control and
prevention, new insights and methodologies in molecular biology keep evolving continuously. In the
recent past, newer studies have revealed deeper knowledge of HPV-activated molecular signaling
pathways as well as prospective targets for early diagnosis, prevention, and therapy of HPV-related
malignancies. Also, there has been much new research conducted on genome-editing tools for HPVinduced
cervical cancer treatment in conjunction with other treatment strategies, such as immunotherapy
and therapeutic vaccines.
Analysis of Microbial and Physicochemical Properties of Raw and
Pasteurized Milk at Some Selected Areas of Tangail District, Bangladesh
Authors: Dey Dipa , Sharmin Saima , Mahmud Shahin , Ali Md. Firoz , Mia Md. Younus 
Published: March 2023

Objectives:
The aim of this study is to analyze the microbial quality and physicochemical
properties of raw and pasteurized milk from Tangail District of Bangladesh.

Methods:
A rigorous study was carried out from April - August 2019 at the Tangail District of
Bangladesh for investigation. A total of 18 samples were examined by following the standard
bacteriological methods and by using a refractometer and digital pH meter.

Results:
The results revealed that the highest log of Total Viable Count (TVC) was found as 6.9
and 8.7 CFU/ml in raw and pasteurized milk, whereas the highest log of Total Coliform Count
(TCC) was found as 4.4 and 6.3 CFU/ml in raw and pasteurized milk, respectively. When the
mean value is greater, then the mean value is displayed on the graph as a logarithm. The highest
log of Total E. coli Count (TE.cC) was 6.6 and 6.4 CFU/ml in raw and pasteurized milk, whereas
the highest log of Total Staphylococcus Count (TSC) was found as 7.6 and 6.5 CFU/ml in raw
and pasteurized milk, respectively. The highest mean pH value was 7.43 and 7.19 in raw and
pasteurized milk and the greatest mean value of Total Soluble Solids (TSS) was found as 6.33
and 10.33% in raw and pasteurized milk.

Conclusion:
It can be summarized that both the raw and pasteurized milk bear higher microorganisms
than standards. It might hurt consumers in the long term. So, the milk producers should
be trained up properly and the apposite authority should inspect hygienic conditions around milk
production and processing and marketed milks to ensure the minimal legal requirements.
In vitro Anti-inflammatory Activity with Ethanolic Leaf Extracts of Rivea
hypocrateriformis LPS Stimulated Raw 264.7 Macrophages
Authors: Nachiar Shanthini , Ramachandran Pathangi Kumar 
Published: March 2023

Aims:
To investigate the effect of R. hypocrateriformis extract on the production of proinflammatory
cytokines by macrophages.

Background:
The whole plant was extracted with ethanol at room temperature. The in vitro antiinflammatory
activity of RH was investigated on lipopolysaccharide (LPS)-stimulated RAW264.7
macrophages.

Objective:
LPS-induced nitric oxide (NO) production was determined by the Griess method. Production
of pro-inflammatory cytokines including Interleukin-1 beta (IL-1 β), Interleukin-6 (IL-6),
tumor necrosis factor-alpha (TNF-α), and cyclooxygenase-2 (COX-2) was examined using reverse
transcriptase - polymerase chain reaction (RT-PCR) and Western blot analysis. Under in vitro conditions,
RH in doses ranging from 6.25 - 100 μg/mL significantly inhibited lipopolysaccharideinduced
nitric oxide production and the production of pro-inflammatory mediators.

Methods:
In vitro determinations of the toxic effects of unknown compounds have been performed
by counting viable cells after staining with a vital dye. Alternative methods used are the measurement
of radioisotope incorporation as a measure of DNA synthesis, counting by automated counters,
and others that rely on dyes and cellular activity. The MTT system is a means of measuring the
activity of living cells via mitochondrial dehydrogenases. The MTT method is simple, accurate, and
yields reproducible results.

Results:
In this study, we investigated whether R. hyocrateriformis can inhibit the production of
pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in LPS-activated macrophages. In addition to its
pivotal role in many body functions, NO has also been implicated in the pathology of many inflammatory
diseases, including arthritis, myocarditis, colitis, and nephritis.

Conclusion:
R. hypocrateriformis extract suppressed the pro-inflammatory cytokine production in
LPS-stimulated RAW264.7 macrophages. Hence, R. hypocrateriformis extract is a potential candidate
for the development of pharmacological agents useful in the treatment of inflammatory diseases.
Further research on the effects and molecular mechanisms of the active compound in the extract
is needed to precisely define thestructure-activity relationship in various molecular regulatory
mechanisms.