bluuebunny/crossref_metadata_2025_split huggingface dataset:
Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor
Authors: Schürfeld Robin , Sandner Benjamin , Hoffmann Annett , Klöting Nora , Baratashvili Ekaterine , Nowicki Marcin , Paeschke Sabine , Kosacka Joanna , Kralisch Susan , Bachmann Anette , Frille Armin , Dietel Anja , Stolzenburg Jens-Uwe , Blüher Matthias , Zhang Ming-Zhi , Harris Raymond C. , Isermann Berend , Stumvoll Michael , Tönjes Anke , Ebert Thomas 
Published: May 2023

ObjectiveAcyl-CoA-binding protein (ACBP)/diazepam-binding inhibitor has lately been described as an endocrine factor affecting food intake and lipid metabolism. ACBP is dysregulated in catabolic/malnutrition states like sepsis or systemic inflammation. However, regulation of ACBP has not been investigated in conditions with impaired kidney function, so far.Design/methodsSerum ACBP concentrations were investigated by enzyme-linked immunosorbent assay i) in a cohort of 60 individuals with kidney failure (KF) on chronic haemodialysis and compared to 60 individuals with a preserved kidney function; and ii) in a human model of acute kidney dysfunction (AKD). In addition, mACBP mRNA expression was assessed in two CKD mouse models and in two distinct groups of non-CKD mice. Further, mRNA expression of mACBP was measured in vitro in isolated, differentiated mouse adipocytes - brown and white - after exposure to the uremic agent indoxyl sulfate.ResultsMedian [interquartile range] serum ACBP was almost 20-fold increased in KF (514.0 [339.3] µg/l) compared to subjects without KF (26.1 [39.1] µg/l) (p&lt;0.001). eGFR was the most important, inverse predictor of circulating ACBP in multivariate analysis (standardized β=-0.839; p&lt;0.001). Furthermore, AKD increased ACBP concentrations almost 3-fold (p&lt;0.001). Increased ACBP levels were not caused by augmented mACBP mRNA expression in different tissues of CKD mice in vivo or in indoxyl sulfate-treated adipocytes in vitro.ConclusionsCirculating ACBP inversely associates with renal function, most likely through renal retention of the cytokine. Future studies need to investigate ACBP physiology in malnutrition-related disease states, such as CKD, and to adjust for markers of renal function.
Validation and marker-assisted selection of DArT-genomic regions associated with wheat yield-related traits under normal and drought conditions
Authors: Hashem Mostafa , Sandhu Karansher Singh , Ismail Saleh M. , Börner Andreas , Sallam Ahmed 
Published: May 2023

Quantitative trait loci (QTL) is one of the most important steps in marker-assisted selection. Few studies have validated quantitative trait loci for marker-assisted selection of yield traits under drought stress conditions in wheat. A set of 138 highly diverse wheat genotypes were tested under normal and drought stress conditions for 2 years. Plant height, heading date, spike length, grain number per spike, grain yield per spike, and 1000-kernel weight were scored. High genetic variation was found among genotypes in all traits scored under both conditions in the 2 years. The same panel was genotyped using a diversity-array technology (DArT) marker, and a genome-wide association study was performed to find alleles associated with yield traits under all conditions. A set of 191 significant DArT markers were identified in this study. The results of the genome-wide association study revealed eight common markers in wheat that were significantly associated with the same traits under both conditions in the 2 years. Out of the eight markers, seven were located on the D genome except one marker. Four validated markers were located on the 3D chromosome and found in complete linkage disequilibrium. Moreover, these four markers were significantly associated with the heading date under both conditions and the grain yield per spike under drought stress condition in the 2 years. This high-linkage disequilibrium genomic region was located within the TraesCS3D02G002400 gene model. Furthermore, of the eight validated markers, seven were previously reported to be associated with yield traits under normal and drought conditions. The results of this study provided very promising DArT markers that can be used for marker-assisted selection to genetically improve yield traits under normal and drought conditions.
Epidemiological characteristics for patients with traumatic brain injury and the nomogram model for poor prognosis: an 18-year hospital-based study
Authors: Guo Shaochun , Han Ruili , Chen Fan , Ji Peigang , Liu Jinghui , Zhai Yulong , Chao Min , Zhao Wenjian , Jiao Yang , Fan Chao , Huang Tao , Wang Na , Ge Shunnan , Qu Yan , Wang Yuan , Wang Liang 
Published: May 2023

ObjectiveTraumatic brain injury (TBI) is a global social, economic, and health challenge that is associated with premature death and long-term disability. In the context of rapid development of urbanization, the analysis of TBI rate and mortality trend could provide abundant diagnosis and treatment suggestions, which helps to form future reference on public health strategies.MethodsIn this study, as one of major neurosurgical centers in China, we focused on the regime shift of TBI based on 18-year consecutive clinical data and evaluated the epidemiological features. In our current study, a total of 11,068 TBI patients were reviewed.ResultsThe major cause of TBI was road traffic injuries (44.%), while the main type of injury was cerebral contusion (n = 4,974 [44.94%]). Regarding to temporal changes, a decreasing trend in TBI incidence for patients under 44 years old was observed, while an increasing trend for those aged over 45 years was indicated. Incidences of RTI and assaults decreased, while ground level fall presented increasing incidences. The total number of deaths was 933 (8.43%), with a decreasing trend in overall mortality since 2011. Age, cause of injury, GCS at admission, Injury Severity Score, shock state at admission, trauma-related diagnoses and treatments were significantly associated with mortality. A predictive nomogram model for poor prognosis was developed based on patient's GOS scores at discharge.ConclusionsThe trends and characteristics of TBI patients changed with rapid development of urbanization in the past 18 years. Further larger studies are warranted to verify its clinical suggestions.
Cochlear implant electrode impedance subcomponents as biomarker for residual hearing
Authors: Schraivogel Stephan , Aebischer Philipp , Weder Stefan , Caversaccio Marco , Wimmer Wilhelm 
Published: May 2023

Introduction and objectivesMaintaining the structural integrity of the cochlea and preserving residual hearing is crucial for patients, especially for those for whom electric acoustic stimulation is intended. Impedances could reflect trauma due to electrode array insertion and therefore could serve as a biomarker for residual hearing. The aim of this study is to evaluate the association between residual hearing and estimated impedance subcomponents in a known collective from an exploratory study.MethodsA total of 42 patients with lateral wall electrode arrays from the same manufacturer were included in the study. For each patient, we used data from audiological measurements to compute residual hearing, impedance telemetry recordings to estimate near and far-field impedances using an approximation model, and computed tomography scans to extract anatomical information about the cochlea. We assessed the association between residual hearing and impedance subcomponent data using linear mixed-effects models.ResultsThe progression of impedance subcomponents showed that far-field impedance was stable over time compared to near-field impedance. Low-frequency residual hearing demonstrated the progressive nature of hearing loss, with 48% of patients showing full or partial hearing preservation after 6 months of follow-up. Analysis revealed a statistically significant negative effect of near-field impedance on residual hearing (−3.81 dB HL per kΩ; p &lt; 0.001). No significant effect of far-field impedance was found.ConclusionOur findings suggest that near-field impedance offers higher specificity for residual hearing monitoring, while far-field impedance was not significantly associated with residual hearing. These results highlight the potential of impedance subcomponents as objective biomarkers for outcome monitoring in cochlear implantation.
Evaluation of dihydrotestosterone and dihydroprogesterone levels and gene expression of genes involved in neurosteroidogenesis in the SH-SY5Y Alzheimer disease cell model
Authors: Radagdam Saeed , Khaki-Khatibi Fatemeh , Rahbarghazi Reza , Shademan Behrouz , Nourazarian Seyed Manouchehr , Nikanfar Masoud , Nourazarian Alireza 
Published: May 2023

IntroductionAlzheimer’s disease (AD) is the most common form of dementia worldwide. This study investigated the effects of lipopolysaccharide on neurosteroidogenesis and its relationship to growth and differentiation using SH-SY5Y cells.MethodsIn this study, we used the MTT assay to assess the impact of LPS on SH-SY5Y cell viability. We also evaluated apoptotic effects using FITC Annexin V staining to detect phosphatidylserine in the cell membrane. To identify gene expression related to human neurogenesis, we utilized the RT2 Profiler TM PCR array human neurogenesis PAHS-404Z.ResultsOur study found that LPS had an IC50 level of 0.25 μg/mL on the SH-SY5Y cell line after 48 h. We observed Aβ deposition in SH-SY5Y cells treated with LPS, and a decrease in DHT and DHP levels in the cells. Our analysis showed that the total rate of apoptosis varied with LPS dilution: 4.6% at 0.1 μg/mL, 10.5% at 10 μg/mL, and 44.1% at 50 μg/mL. We also observed an increase in the expression of several genes involved in human neurogenesis, including ASCL1, BCL2, BDNF, CDK5R1, CDK5RAP2, CREB1, DRD2, HES1, HEYL, NOTCH1, STAT3, and TGFB1, after treatment with LPS at 10 μg/mL and 50 μg/mL. LPS at 50 μg/mL increased the expression of FLNA and NEUROG2, as well as the other genes mentioned.ConclusionOur study showed that LPS treatment altered the expression of human neurogenesis genes and decreased DHT and DHP levels in SH-SY5Y cells. These findings suggest that targeting LPS, DHT, and DHP could be potential therapeutic strategies to treat AD or improve its symptoms.
Modelling performance by continents in swimming
Authors: Yustres Amores I. , Santos del Cerro J. , González-Mohíno F. , Hermosilla F. , González-Ravé J. M. 
Published: May 2023

Introduction: There is a growing interest in the scientific community about the progression and congruity in the performance of talented participants who complete representing different nations in the most important international events. The prediction of incoming performances is nowadays in demand with the objective of returning in talent investment. Talent identification programs have tried to select and develop sports talent over years. However, to our knowledge, there is a lack of research about success in swimming World Championships (WCs) performance considering continents-country and how successful outcomes are influenced by these variables. Therefore, the primary goal is to analyze the effect of early specialization comparing the performance progression model of the countries gathered by continents.Methods: Participant’s data from all Junior and Senior WCs between 2006 and 2017 from International Swimming Federation (FINA). One-way ANOVA, ANCOVA and regression model were used to explain whether the variable category, age, best z-score, experience, and continent influences the performance obtained in Absolute WC.Results: Significant differences (p &lt; 0.01) were found between the average performance obtained by the two different categories (junior: swimmers participating in junior WCs before senior WCs; senior: swimmers participating in senior WCs without previous participation in junior WCs), where swimmers from category junior showed significant better performance’s times than seniors, except in America. ANCOVA results showed that generally, the greatest differences where in the earliest ages, with best performance registered in category junior in all the continents. Also, the experience was a significant variable in the general model.Conclusion: Swimmers who had participated in junior category prior absolute obtained better performance’s times than those swimmers who participated directly in absolute, in the first participation in senior WC. Thus, early specialization is a key factor to obtain better results in senior WCs for all the continents, except in America.
Effects of a 24-week exercise program on anthropometric, body composition, metabolic status, cardiovascular response, and neuromuscular capacity, in individuals with intellectual and developmental disabilities
Authors: Jacinto Miguel , Matos Rui , Monteiro Diogo , Antunes Raul , Caseiro André , Gomes Beatriz , Campos Maria João , Ferreira José Pedro 
Published: May 2023

Introduction: The prevalence of overweight and obesity has increased in the last decades, including in people with Intellectual and Developmental Disabilities (IDD). This is even more concerning when it is globally accepted that a low physical condition contributes to the deterioration of functionality and increases the risk of developing chronic diseases during life, with effective implications for health and well-being. The aim of the present study is to investigate the effects of two physical exercise intervention programs on institutionalized individuals with IDD.Methods: Twenty-one adults with IDD (43.04 ± 11.18 years) were split by convenience into three groups: i) an indoor training group (IG; N = 7; 24-week machine-based gym intervention), ii) an outdoor training group (OG; N = 7; 24-week outdoor intervention with low-content materials), and iii) a control group (CG; N = 7). Assessed outcomes included indicators of health and neuromuscular capacity. The ShapiroWilk (n &lt; 50) and Levene tests were used to verify data normality and homoscedasticity. A Kruskal-Walli test was performed to understand if there were differences between the groups. For comparison purposes and to assess hypothetical differences between groups, the Wilcoxon signed-rank test and the Friedman test were used. The respective effect size was calculated, and the significance level was defined at 0.05.Results/Discussion: There was a difference in fat mass in OG (initial ≠ intermediate; Bonferroni corrected: t = 2.405; p = 0.048; W = 0.08 and initial ≠ final moments; Bonferroni corrected: t = 2.405; p = 0.048; W = 0.08). Indoor intervention programs seem to be more effective than outdoor intervention programs for reducing heart rate rest (t = −2.912; p = 0.011; W = −0.104) when compared with CG.Conclusion: A low-cost outdoor intervention in contact with nature appears to be more effective for fat mass reduction. The results for heart rate variability are not clear and robust. Finally, an indoor intervention using weight-training machines appears to be a good method to promote neuromuscular capacity.
Documenting heritage language experience using questionnaires
Authors: Tomić Aleksandra , Rodina Yulia , Bayram Fatih , De Cat Cécile 
Published: May 2023

IntroductionThere exists a great degree of variability in the documentation of multilingual experience across different instruments. The present paper contributes to the “methods turn” and individual differences focus in (heritage) bilingualism by proposing a comprehensive online questionnaire building on existing questionnaires and the experience of using them to document heritage bilingualism: the Heritage Language Experience (HeLEx) online questionnaire. HeLEx is validated against and contrasted to an extended version of the Language and Social Background Questionnaire designed for heritage speakers (HSs), LSBQ-H.MethodsWe compare data elicited with both questionnaires in turn from a group of Turkish HSs (n = 174, mean age=32). Our validation focuses on traditional language background variables, including language exposure and use, language proficiency, language dominance, as well as a more novel measure of language entropy. The analyses are based on a subset of key questions from each questionnaire that capture language experience for up to five languages, four modalities, and five social contexts. In a subsequent set of analyses, we explore the impact of different types of response scales, response mechanisms, and manners of variable derivation on the informativity of the data they can provide, in terms of the scope, granularity and distributional properties of the derived measures.Results and DiscussionOur results show that both HeLEx and LSBQ-H are successful at detecting the important distributional patterns in the data and reveal a number of advantages of HeLEx. In the discussion, we consider the impact of methodological choices regarding question phrasing, visual format, response options, and response mechanisms. We emphasize that these choices are not trivial and can affect the derived measures and subsequent analyses on the impact of individual differences on language acquisition and processing.
Supratentorial cerebrospinal fluid diversion using image-guided trigonal ventriculostomy during retrosigmoid craniotomy for cerebellopontine angle tumors
Authors: Roethlisberger Michel , Eberhard Noëmi Elisabeth , Rychen Jonathan , Al-Zahid Saif , Jayapalan Ronie Romelean , Zweifel Christian , Karuppiah Ravindran , Waran Vicknes 
Published: May 2023

BackgroundCerebellar contusion, swelling and herniation is frequently encoutered upon durotomy in patients undergoing retrosigmoid craniotomy for cerebellopontine angle (CPA) tumors, despite using standard methods to obtain adequate cerebellar relaxation.ObjectiveThe aim of this study is to report an alternative cerebrospinal fluid (CSF)-diversion method using image-guided ipsilateral trigonal ventriculostomy.MethodsSingle-center retro- and prospective cohort study of n = 62 patients undergoing above-mentioned technique. Prior durotomy, CSF-diversion was performed to the point where the posterior fossa dura was visibly pulsatile. Outcome assessment consisted of the surgeon's intra- and postoperative clinical observations, and postoperative radiological imaging.ResultsFifty-two out of n = 62 (84%) cases were eligible for analysis. The surgeons consistently reported successful ventricular puncture and a pulsatile dura prior durotomy without cerebellar contusion, swelling or herniation through the dural incision in n = 51/52 (98%) cases. Forty-nine out of n = 52 (94%) catheters were placed correctly within the first attempt, with the majority of catheter tips (n = 50, 96%) located intraventricularly (grade 1 or 2). In n = 4/52 (8%) patients, postoperative imaging revealed evidence of a ventriculostomy-related hemorrhage (VRH) associated with an intracerebral hemorrhage [n = 2/52 (4%)] or an isolated intraventricular hemorrhage [n = 2/52 (4%)]. However, these hemorrhagic complications were not associated with neurological symptoms, surgical interventions or postoperative hydrocephalus. None of the evaluated patients demonstrated radiological signs of upward transtentorial herniation.ConclusionThe method described above efficiently allows CSF-diversion prior durotomy to reduce cerebellar pressure during retrosigmoid approach for CPA tumors. However, there is an inherent risk of subclinical supratentorial hemorrhagic complications.
TRADITIONAL AND INNOVATIVE PEDAGOGICAL TECHNOLOGIES FOR THE FORMATION OF VALUES OF MASTERS IN HUMANITIES IN THE PROCESS OF PROFESSIONAL TRAINING
Authors: Lukyanenko O. , Vynnychuk R. 
Published: May 2023

The article clarifies the prospects for the process of training Masters in the field of Humanities of those traditional pedagogical technologies that contain a set of methods, forms, techniques and tools aimed at forming the values of general culture and professional activity: modular, tutoring, project-based and individual as the most widely used in the world and the domestic practice of training specialists at the Master’s level. It was determined that in the process of choosing educational technologies as structural components of the system of training Masters in the humanitarian field (specialties 031 Religious studies, 032 History and archeology, 034 Cultural studies, 033 Philosophy, 035 Philology) on axiological principles, an innovative educational environment is formed based on the principles of: open learning; reliance on information technologies; designing the integrated content of education; application of innovative pedagogical approaches to the formation and development of universal and professional values; changes in the traditional role of a university teacher from a translator of knowledge to mastering the mission of a mentor, consultant, and senior colleague. The necessity of creative application of suggestive-pedagogical technology for the development of humanitarian values in the unity of three directions is proven: direct suggestion (imperative and motivated); use of efficiency catalysts (music, role-playing, theatricalization); and analysis of own valuable experience. The prospects of the research include the justification in the context of the selected problem of innovative aspects of technology / asynchronous learning and the search for methodological foundations for the implementation of suggestive-pedagogical methods based on the axiological scientific approach.
THE DISCIPLINE «SOCIO-CULTURAL DESIGN» IN THE SYSTEM OF PROFESSIONAL TRAINING OF A CULTUROLOGIST
Authors: Dmytrenko V. , Dmytrenko V. 
Published: May 2023

The article analyzes the place and role of the discipline «Socio-cultural design» in the system of professional training in cultural studies. It has been established that this course or a similar one by name is present in the educational programs of the majority of higher educational institutions that train cultural specialists. We believe that specialists from various educational institutions regard it as an essential component of the professional education of a bachelor of cultural studies. It has been found that the modern labor market needs a project-oriented professional which is why the developers of the standard of higher education in the specialty 034 Cultural studies have foreseen in its structure the competencies that form such a specialist.
The analysis of the educational content of some higher educational institutions has made it possible to single out the tasks characteristic of the subject «Socio-cultural design». These include elucidation of the theoretical and methodological foundations of socio-cultural design; analysis of the socio-cultural environment as a prerequisite for the project process; studying different types of design and mastering practical (technological) design skills. The study of the discipline content has showed that the topics presented in the programs are divided into theoretical and practical blocks/modules. Usually, the hourly preference is given to the practical module or their ratio is equal. This approach corresponds to the goals of education stated in the standard of higher education and shows that its teaching is oriented, first of all, to the formation of applied skills. It has been established that the selection of topics corresponds to the current state of scientific development of the issues of socio-cultural design and methodical approaches to its teaching. We note the fundamental similarity of the subjects in the programs of different higher education institutions.
We believe that the success of a culturologist’s professional activity largely depends on the level of his mastery of the technologies of competent analysis of a specific socio-cultural situation and the skills of developing and implementing projects and programs capable of significantly improving the existing situation.
It has been established that, in addition to the ability to generate projects, «Socio-cultural design» develops other competencies necessary for a cultural researcher. In particular, during its study, students of higher education develop skills in presenting the products of their professional activities, analytical skills, the ability to select appropriate arguments using current and relevant sources, etc.