bluuebunny/crossref_metadata_2025_split huggingface dataset:
The burden of disease and economic impact of sugar-sweetened beverages’ consumption in Argentina: A modeling study
Authors: Bardach Ariel Esteban , Espínola Natalia , Cairoli Federico Rodríguez , Perelli Lucas , Balan Darío , Palacios Alfredo , Augustovski Federico , Pichón-Riviere Andrés , Alcaraz Andrea Olga 
Published: February 2023

Background
Approximately two-thirds of Argentine adults are overweight or obese, and 11% have diabetes. Over the last two decades, all population groups have increased their consumption of ultra-processed foods and sugar-sweetened beverages (SSB). We aimed to estimate the disease burden—deaths, events, and costs to the health system—attributed to SSB consumption in Argentina.

Methods
We used a comparative risk assessment framework to estimate the health and economic impacts that would be avoided in a scenario without sugar-sweetened beverage (SSB) consumption. We calculated the direct effects on diabetes, cardiovascular disease, and BMI, and then estimated the effects of BMI on disease incidence. Finally, we applied the population attributable factor to calculate the health and economic burden avoided in Argentina in 2020.

Results
Our model estimated that about 4,425 deaths, 110,000 healthy life years lost to premature death and disability, more than 520,000 cases of overweight and obesity in adults, and 774,000 in children and adolescents would be attributed to SSB Consumption in Argentina. This disease burden corresponds to 23% of type-2 diabetes cases and other significant proportions of cardiovascular disease and cancer. The overweight and obesity costs attributable to SSB totaled approximately $47 million in adults and $15 million in children and adolescents.

Conclusion
A significant number of disease cases, deaths, and health care costs could be attributed to SSB consumption in Argentina. Implementing measures to reduce the sugar content in beverages is a pending debt for the country and could lead to measurable improvements in population health, especially among children and adolescents.
Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
Authors: Saeheng Teerachat , Na-Bangchang Kesara 
Published: February 2023

Background
Declining in susceptibility of Plasmodium falciparum to mefloquine is reported in South-East Asia. A revisiting on mefloquine pharmacokinetics-pharmacodynamics (PK/PD) could assist in finding new appropriate dosage regimens in combination with artesunate as a three-day course treatment.

Objective
This study aimed to investigate promising alternative artesunate-mefloquine combination regimens that are effective for the treatment of patients with mefloquine-sensitive and resistant P. falciparum malaria.

Methods
Data collected during 2008–2009 from 124 patients with uncomplicated P. falciparum malaria were included in the analysis, 90 and 34 patients with sensitive and recrudescence response, respectively. All patients were treated with a three-day combination of artesunate-mefloquine. Population PK-PD models were developed. The developed models were validated with clinically observed data. Simulations of clinical efficacy of alternative mefloquine regimens were performed based on mefloquine sensitivity, patients’ adherence and parasite biomass.

Results
The developed PK/PD models well described with clinically observed data. For mefloquine-resistant P. falciparum, a three-day standard regimen of artesunate-mefloquine is suitable (>50% efficacy) only when the level of parasite sensitivity was < 1.5-fold of the cut-off level (IC50 < 36 nM). For mefloquine-sensitive parasite with IC50 < 23.19 nM (0.96-fold), all regimens provided satisfactory efficacy. In the isolates with IC50 of 24 nM, regimen-I is recommended. Curative treatment criteria for mefloquine and artesunate were C336h (>408 ng.mL-1) or Cmax/IC50 (>130.1 g.m/M), and Cmax/IC50 (>381.2 g.m/M), respectively.

Conclusions
Clinical use of a three-day standard artesunate-mefloquine is suitable only when the IC50 of P. falciparum isolates is lower than 36 nM. Otherwise, other ACT regimens should be replaced. For mefloquine-sensitive parasite, a dose reduction is recommended with the IC50 is lower than 23.19 nM.
Is metformin use associated with low mortality in patients with type 2 diabetes mellitus hospitalized for COVID-19? a multivariable and propensity score-adjusted meta-analysis
Authors: Ma Zhiyuan , Krishnamurthy Mahesh 
Published: February 2023

BackgroundCoronavirus disease 2019 (COVID-19) is a new pandemic that the entire world is facing since December of 2019. Increasing evidence has shown that metformin is linked to favorable outcomes in patients with COVID-19. The aim of this study was to address whether outpatient or inpatient metformin therapy for type 2 diabetes mellitus is associated with low in-hospital mortality in patients hospitalized for COVID-19.MethodsWe searched studies published in PubMed, Embase, Google Scholar and Cochrane Library up to November 1, 2022. Raw event data extracted from individual study were pooled using the Mantel-Haenszel approach. Odds ratio (OR) or hazard ratio (HR) adjusted for covariates that potentially confound the association using multivariable regression or propensity score matching was pooled by the inverse-variance method. Random effect models were applied for meta-analysis due to variance among studies.ResultsTwenty-two retrospective observational studies were selected. The pooled unadjusted OR for outpatient metformin therapy and in-hospital mortality was 0.48 (95% CI, 0.37–0.62) and the pooled OR adjusted with multivariable regression or propensity score matching was 0.71 (95% CI, 0.50–0.99). The pooled unadjusted OR for inpatient metformin therapy and in-hospital mortality was 0.18 (95% CI, 0.10–0.31), whereas the pooled adjusted HR was 1.10 (95% CI, 0.38–3.15).ConclusionsOur results suggest that there is a significant association between the reduction of in-hospital mortality and outpatient metformin therapy for type 2 diabetes mellitus in patients hospitalized for COVID-19.
Scenography and Art History: Performance Design and Visual Culture, Astrid Von Rosen and Viveka Kjellmer (eds) (2021)
Authors: Rewa Natalie 
Published: February 2023

Review of: Scenography and Art History: Performance Design and Visual Culture, Astrid Von Rosen and Viveka Kjellmer (eds) (2021)
London: Bloomsbury Visual Arts, 256 pp.,
ISBN 978-1-35020-444-7, h/bk, £85.00
Elevated Hemolysis Index is associated with higher risk of cardiovascular diseases
Authors: Gils Charlotte , Hansen Dennis Lund , Nybo Mads , Frederiksen Henrik 
Published: February 2023

Abstract

Objectives

In vivo hemolysis is associated with thromboembolism. Although an increased Hemolysis Index (HI) can be due to in vitro as well as in vivo hemolysis, both reflects a more fragile erythrocyte population. We therefore hypothesized that HI above upper reference limit would be associated with an increased risk of cardiovascular disease (CVD).

Methods
We identified persons with two elevated HI (HI+) from blood samples analyzed at a university hospital laboratory from 2012 to 2017. We compared their risk of CVD with the risk in matched comparators with normal HI and from the general population. HI+ persons and comparators were followed from start date (date of the second elevated HI) until the first of the main outcome: CVD, emigration, death, or end of observation time on December 31, 2018.

Results
In 43,102 unique HI+ persons, the risk of developing CVD was 40% higher compared with the general population and 13% higher compared with the matched blood sample cohort. HI+ was associated with a significantly increased cumulative incidence of both arterial and venous CVD compared with the matched blood sample cohort and the general population (respectively 47 and 14% for arterial CVD; 78 and 24% for venous CVD). Moreover, overall mortality risk was significantly higher in patients with HI+ than in the two comparator groups.

Conclusions
Elevated HI is associated with increased risk of arterial and venous CVD and with increased mortality. Our findings imply that HI may contribute as a CVD risk biomarker.
Evaluation of a rough-surface evaporator applied to an absorption heat transformer for water desalination
Authors: Romero David Juárez , Rivera Irán Ortiz , Canela Sánchez Isaac Justine , Ortega Mojica Nancy Isamar , Huicochea Armando , Gonzaga Javier Delgado 
Published: February 2023

Abstract
The purpose of this work is to evaluate the performance of a rough-textured evaporator applied to a single-stage absorption heat transformer for water desalination (SAHT-WD). The stainless-steel evaporator was subjected to an abrasive material release treatment (sandblast texture) to provide a texture that fosters phase change heat transfer compared to a smooth surface. To determine the performance of the evaporator, the evaluation has been divided into an experimental and a theoretical analysis. The experimental analysis focused on determining the operating conditions that favor the performance of the evaporator and the SAHT-WD. For the theoretical analysis, a mathematical model was developed to predict the wetting efficiency and the heat-transfer coefficients of the evaporator. To quantify the improvement in the performance of the rough-surface evaporator, the experimental results were compared with those reported in a reference work. The results indicate that the sandblasted texture improved the performance of the evaporator as well as that of the SAHT-WD. The results of the mathematical model suggest that the rough tube improved the wetting efficiency of the evaporator.
Food or rut: contrasting seasonal patterns in fat deposition between males and females of northern and southern sika deer populations in Japan
Authors: Takatsuki Seiki , Hosoi Eiji , Tado Hiroyuki 
Published: February 2023

Abstract
Overwintering is important for the survival of northern mammals, and northern ungulates deposit body fat. Researchers have interpreted fat deposition as an adaptation to food shortages during winter. However, it is likely that reproductive activities also affect fat deposition. We compared kidney fat indices (KFIs) of sika deer (Cervus nippon) between the northern and southern populations in Japan. In the northern population, the KFIs of adult males and females peaked during summer and autumn, respectively. In adult males, the KFIs abruptly declined during the rut (October), while in yearling males and fawns, they were low in summer. In the southern population, KFIs of adult males were high in summer but decreased in October. KFIs of adult females were low and increased in December–January. KFIs of fawns were low. These results suggest that most classes of the southern population did not deposit much fat during the summer except for adult males. The result that southern adult males displayed as much fat deposition as the northern males suggests that body fat was deposited not only for overwintering but also for reproductive activity of adult males.
Wide field of view and full Stokes polarization imaging using metasurfaces inspired by the stomatopod eye
Authors: Liu Jianying , Chu Jinkui , Zhang Ran , Liu Rui , Fu Jiaxin 
Published: February 2023

Abstract
Wide field of view and polarization imaging capabilities are crucial for implementation of advanced imaging devices. However, there are still great challenges in the integration of such optical systems. Here, we report a bionic compound eye metasurface that can realize full Stokes polarization imaging in a wide field of view. The bionic compound eye metasurface consists of a bifocal metalens array in which every three bifocal metalenses form a subeye. The phase of the bifocal metalens is composed of gradient phase and hyperbolic phase. Numerical simulations show that the bifocal metalens can not only improve the focusing efficiency in the oblique light but also correct the aberration caused by the oblique incident light. And the field of view of the bionic compound eye metasurface can reach 120° × 120°. We fabricated a bionic compound eye metasurface which consists of three subeyes. Experiments show that the bionic compound eye metasurface can perform near diffraction-limited polarization focusing and imaging in a large field of view. The design method is generic and can be used to design metasurfaces with different materials and wavelengths. It has great potential in the field of robot polarization vision and polarization detection.
High-sensitivity polarization-independent terahertz Taichi-like micro-ring sensors based on toroidal dipole resonance for concentration detection of Aβ protein
Authors: Liu Wencan , Zhou Xinwei , Zou Shucai , Hu Zhengguang , Shen Yun , Cai Mengqiang , Lin Dongdong , Zhou Jia , Deng Xiaohua , Guo Tianjing , Lei Jiangtao 
Published: February 2023

Abstract
Terahertz (THz) metamaterial sensor is a newly-developing interdisciplinary technology, which combines the essential characteristics of THz spectroscopy and metamaterials, to obtain better sensitivity for trace detection of the different target analytes. Toroidal dipole resonances show great sensing potential due to their suppression of the radiative loss channel. Here, we found a high-quality planar toroidal dipole resonance in the breaking Chinese Taichi-like ring and then designed a novel polarization-independent terahertz toroidal sensor by combining four Taichi-like rings into a cycle unit. The sensor shows high-sensitivity sensing characteristics for the ultrathin analyte and refractive index. The optimized sensitivity of pure analytes under 4 μm coating thickness can numerically reach 258 GHz/RIU in the corresponding ∼1.345 THz frequency domain, which is much higher than that of previously reported sensors. We further fabricated experimentally the sensor and demonstrated its fascinating polarization-independent characteristics. Finally, it was successfully applied to the low-concentration detection (ranging from 0.0001 mg/mL to 10 mg/mL) of Aβ protein associated with Alzheimer’s disease. Our high-sensitivity polarization-independent THz toroidal dipole sensor would give access to rich applications in label-free biosensing.
Synthesis and crystal structure of (4aR,7S)-7-hydroxy-7-isopropyl-1,1-dimethyldecahydro-2H,6H-8a,4a-(epoxymethano)phenanthren-12-one, C20H32O3
Authors: Chen Ren-Song , Zhang Jing-Jie , Zhang Yi , Xu Chuan-Yan , Ye Jiang-Hai 
Published: February 2023

Abstract
C20H32O3, monoclinic, P21 (no. 4), a = 7.8981(17) Å, b = 10.302(2) Å, c = 11.028(3) Å, β = 90.020(2)°, V = 897.3(3) Å3, Z = 2, R

gt
(F) = 0.0603, wR

ref
(F
2) = 0.1342, T = 273(2) K.
Ultrasonic longitudinal torsion-assisted biotic bone drilling: An experimental study
Authors: Li Zhenhao , Yang Zhibo , Wang Wei , Guo Qiang , Sun Wang , Han Daocheng , Liu Xiaoning , Zhang Yanru 
Published: February 2023

Abstract
State-of-the-art treatment of such orthopedic diseases as fracture and femoral head necrosis implies the installation of prosthesis or fixed equipment into patients’ injured parts using bone drilling. This study proposes an ultrasonic longitudinal torsion-assisted drilling (ULTAD) technique for biotic bone drilling. A comparative experiment was carried out between conventional drilling and ULTAD drilling in biotic bone, namely porcine femur. These tests proved that under the same drilling parameters, the ultrasonic component in bone drilling could reduce the drilling temperature and forces, improve the material removal by chip breaking, shorten the length of bone debris, and facilitate their discharge. Moreover, the proposed ULTAD technique reduced the number, length, and width of microcracks in the borehole wall, thus protecting the drilled biotic bone from internal damage.
Common fixed-point theorems for non-linear non-self contractive mappings in convex metric spaces
Authors: Kumar Santosh , Aron David 
Published: February 2023

Abstract
In this article, two pairs of non-self mappings satisfying a collection of non-linear contractive conditions in convex metric space are considered to prove a common fixed-point theorem. An appropriate example is provided to support the results proved herein. In addition, we have proved a theorem as an application of our main result. Our results generalize and extend several existing theorems in the literature.
UNIDADE CUIDATIVA
Authors: Carriconde Fripp Julieta , Da Fonseca Sanghi Simone , Hartmann Buss Izabel 
Published: February 2023

A pandemia causada pelo novo coronavírus (COVID-19) tornou-se um dos grandes desafios do século XXI, configurando-se como um sério problema de saúde pública e requerendo ações para seu enfrentamento. De acordo com a Organização Mundial de Saúde (OMS), a pandemia já atingiu mais de 117 países pelo mundo com impactos ainda inestimáveis que afetam direta e/ou indiretamente a saúde e a economia da população mundial. Nesse sentido, este artigo pauta-se por ações de extensão que foram construídas com o objetivo de trabalhar, inicialmente, questões de prevenção e educação em saúde e, depois, fazer intervenções de cuidados, desde a reabilitação física aos aspectos psicossociais para pacientes que apresentaram sequelas da síndrome Pós COVID, em um Ambulatório de Cuidados Paliativos da Universidade Federal de Pelotas no RS. As ações focaram, inicialmente, a conscientização da população quanto ao uso de máscaras, confecção e distribuição das mesmas, gratuitamente, aos setores mais vulneráveis da cidade. Tudo isso contando com o envolvimento de pacientes, familiares e voluntários para minimizar o contágio e, consequentemente, contribuir para o achatamento da curva de contaminação populacional. Na sequência, foram realizadas ações para intervir em problemas de ordem física, psicossocial, ocupacional e espiritual em pessoas que foram acometidas pelo SARS-Cov- 2 com formas moderada e grave, egressos ou não de internação hospitalar pós covid. Dessa forma, essas ações vêm contribuindo de forma sequencial para o enfrentamento dessa pandemia, desde a prevenção até o processo de reabilitação.
EDUCAÇÃO INTERPROFISSIONAL E O USO DAS TICS, REDES SOCIAIS E PORTFÓLIOS NO CONTEXTO DA PANDEMIA PELO COVID-19
Authors: Fin Motta Roberta , Da Silva Meneses Amanda , Gabriele Silva da Silva Julie , Aguiar Lemos Eduarda , Souza da Silva Gabriela , Greggio Samuel 
Published: February 2023

O objetivo deste trabalho é relatar a experiência realizada pelo subgrupo “Atenção à Saúde Mental” no projeto “PET-Saúde Interprofissionalidade” (2019-2021), na construção e desenvolvimento de ações extensionistas inovadoras durante a pandemia da COVID-19. O Programa de Educação pelo Trabalho para a Saúde (PET-Saúde) foi criado pelo Ministério da Saúde (MS), envolvendo preceptores, vinculados à Secretaria Municipal de Saúde de Porto Alegre (RS), docentes/tutores e estudantes/bolsistas de Escolas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Dentre as diversas atividades propostas e metodologias inovadoras realizadas pelo grupo, foi a construção do aprendizado junto à coordenação, à tutoria e à preceptoria que fizeram com que o projeto colocasse em prática o trabalho colaborativo em saúde. Concluímos que foi possível aplicar a interprofissionalidade na prática, enfatizando as estratégias utilizadas para ações de inovação social através dos portfólios, redes sociais e Tecnologias da Informação e Comunicação (TICs).
INOVAÇÃO NA “SALA DE AULA” DA UNIVERSIDADE ABERTA PARA IDOSOS
Authors: Schüler Cavalli Adriana , Laura Hennicka Ana , Segú Copello Fabiola , Gabrielle da Silva Reis Millen , Olivera Cavalli Marcelo 
Published: February 2023

A pandemia do COVID-19 mudou o cenário mundial e incentivou o uso das tecnologias digitais em ambientes educacionais e de interação social. Os idosos do programa estratégico da Universidade Aberta Para Idosos da UFPel tiveram que se reinventar e se adaptar ao estilo de aulas no modo remoto. Este estudo descritivo tem o objetivo de determinar a percepção subjetiva dos idosos neste novo formato de aulas não presenciais. Dos trinta e sete idosos participantes em dois cursos de atualização ofertados em 2021, vinte e dois deles responderam ao questionário no Google Forms. O uso do celular foi predominante no atendimento das palestras (90,9%), e mais da metade da amostra (59,5%) relatou ter considerado fácil o acesso às mesmas. Faz-se necessário ponderar que 72% dos idosos indicaram ter participação prévia em outros tipos de aulas pela Internet. Entretanto, 50% dos idosos afirmaram ter tido dificuldades no acesso às palestras por problemas de conexão da internet; por não ouvir direito as falas; e/ou não conseguir participar das discussões em grupo. As palestras de forma não presencial, apesar de terem sido um desafio para muitos dos idosos, trouxeram um pouco de acolhimento neste período de incertezas e ansiedades por meio da aproximação com seus pares e professores, mesmo que de forma remota. Os idosos demonstraram interesse e satisfação neste novo formato de ensino.
SKETCHES URBANOS EM PEQUENAS CIDADES NO NORDESTE BRASILEIRO
Authors: Gomes Machado Eduardo , Dias André , Valdelia Carlos Chagas de Freitas Maria , Maria Francolino da Silva Stefania , Anne Souza da Silva Geyse 
Published: February 2023

Esta memória visual apresenta oito sketches urbanos produzidos por André Dias, artista visual cearense, em parceria com grupo de extensão e pesquisa situado na Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB). Apresentamos oito sketches urbanos que registram duas pequenas cidades interioranas do Nordeste brasileiro, Redenção e Acarape, no Ceará. Os sketches retratam cenas ou situações cotidianas dos espaços urbanos, através de desenhos que articulam diferentes técnicas, materiais e suportes. Os sketches farão parte de uma exposição itinerante que circulará por espaços públicos e escolas das duas cidades, objeti- vando a efetivação de aprendizagem, a construção de diálogos, a valorização de conhecimentos e potenciais efeitos na produção social do espaço urbano. Essa experiência entrelaça ações de extensão e de pesquisa realizadas em duas pequenas cidades, impactadas pela implantação de uma universidade federal pública interiorizada e internacionalizada a partir de 2011. Interessam-nos os lugares, as situações e as dinâmicas urbanas cotidianas, considerando uma diversidade de agentes que, convivendo reiteradamente, ocupam, usam e produzem as cidades. Com destaque para as juventudes estudantis urbanas, com grande parcela delas sendo originária de outras localidades, municípios e países, buscamos perceber como vivenciam e lidam com os desafios cotidianos enfrentados nos espaços urbanos. A metodologia, envolvendo pré-produção, produ- ção e pós-produção, será detalhada no texto.