bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflective supervision and consultation and its impact within early childhood‐serving programs: A systematic review
Authors: Huffhines Lindsay , Herman Rachel , Silver Rebecca B. , Low Christine M. , Newland Rebecca , Parade Stephanie H. 
Published: August 2023

AbstractReflective supervision and consultation (RS/C) is regarded as best practice within the infant/early childhood mental health field. Benefits of RS/C on the early childhood workforce and children and families have been demonstrated through case studies, conceptual pieces, and individual research studies. However, findings across studies have not been summarized using gold‐standard methodology, thus the state of existing empirical support for RS/C is unclear. This systematic review examined the collective evidence for RS/C across diverse early childhood‐serving programs. Electronic databases were searched to identify studies investigating associations between RS/C and professionals’ reflective capacity and well‐being, child/family outcomes, and implementation factors. Twenty‐eight papers were identified. Studies showed positive associations between RS/C and early childhood‐serving professionals’ reflective capacity and well‐being, with qualitative studies reporting more consistent results than studies using quantitative methods. Many methodological limitations were identified, including incomplete reporting of study designs and participant characteristics, variability in outcome measures, and lack of randomization and comparison groups. Furthermore, few studies examined child and family outcomes. Therefore, while RS/C shows great promise, it was difficult to ascertain its overall effectiveness from an empirical standpoint. Establishing RS/C as an empirically supported approach will be possible with more rigorous research.
Front Cover
Authors: Bowen Robert , Arany Praveen R. 
Published: August 2023

There is increasing recognition of post‐COVID‐19 sequelae involving chronic fatigue and brain fog for which Photobiomodulation (PBM) therapy has been utilized. The study by outlines the benefits of PBM therapy (transcranial or wholebody) as a non‐invasive, sustainable approach for the increasing need for long‐COVID management.For further details please visit the article by Robert Bowen and Praveen R Arany (e202200391). Image: the_lightwriter/stock.adobe.com
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Serum leucine‐rich alpha‐2 glycoprotein in monitoring disease activity and intestinal mucosal healing for biotherapy‐naïve cases with ulcerative colitis
Authors: Kono Masashi , Komeda Yoriaki , Tribonias George , Yoshida Saki , Nomura Kenji , Handa Kohei , Nagai Tomoyuki , Hagiwara Satoru , Omoto Shunsuke , Takenaka Mamoru , Nishida Naoshi , Tsuji Naoko , Kashida Hiroshi , Kudo Masatoshi 
Published: August 2023

AbstractBackground and AimSerum leucine‐rich alpha‐2 glycoprotein level has been reported to be a useful biomarker in assessing mucosal healing in patients undergoing biotherapy, where mucosal lesions caused by ulcerative colitis are difficult to assess endoscopically. However, no such reports have been reported in biotherapy‐naïve cases.MethodsSixty‐eight patients with ulcerative colitis (UC) who were biotherapy‐naïve at Kindai University Hospital between October 2021 and October 2022 were enrolled. We prospectively examined the correlation between leucine‐rich alpha‐2 glycoprotein (LRG), C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), and Geboes scores with clinical endoscopic activity using the Mayo endoscopic subscore (MES).ResultsMucosal healing was achieved in 39 (57%) patients. Univariate analysis revealed that the factors associated with mucosal healing were LRG (P = 0.0024), CRP (P = 0.1078), ESR (P = 0.0372), and Geboes scores (P = 0.0075). Logistic regression analysis identified LRG and Geboes scores as independent factors associated with mucosal healing assessed using MES (P = 0.0431 for LRG and P = 0.0166 for Geboes scores).ConclusionLRG was found to be the easiest marker to monitor disease activity and mucosal inflammation in UC patients with biotherapy‐naïve cases, with a performance equivalent to that of Geboes scores.
Global value chains participation and environmental pollution in developing countries: Does digitalization matter?
Authors: Ali Essossinam , Bataka Hodabalo , Wonyra Kwami Ossadzifo , Awade Nadège Essossolim , Braly Nèmè Nalèwazou 
Published: August 2023

AbstractThe study analyses the effect of global value chains participation (GVCP) on CO2 emissions and assesses whether digitalization technologies can enhance environmental quality. We use panel data estimation techniques for 112 developing countries over the period 1990–2018. Findings show that the GVCP contributes to environmental degradation. Other factors that increase environmental damage include FDI inflows, industrial value‐added and electricity consumption. However, renewable energy consumption significantly reduces CO2 emissions. Findings show that digitalization is an effective channel in reducing CO2 emissions in the GVCP in developing countries. These findings have important policy implications in exploring the GVCP's development dynamics in upgrading opportunities from digital technologies to reduce environmental pollution and promote sustainable growth in developing economies.
Incidence and severity of SARS‐CoV‐2 reinfection, a multicenter cohort study in Shanghai, China
Authors: Yu Weien , Guo Yue , Hu Tiantian , Liu Yuqi , Fan Qingqi , Guo Li , Zheng Binrong , Kong Yide , Zhu Haoxiang , Yu Jie , Chen Shiqi , Zhang Yongmei , Wang Jinyu , Li Fahong , Yang Feifei , Wang Yuee , Zhu Yuzhen , Huang Yuxian , Shen Zhongliang , Ruan Yi , Mao Richeng , Zhang Jiming 
Published: August 2023

AbstractDuring March 2022 to January 2023, two Omicron waves hit Shanghai and caused a massive number of reinfections. To better understand the incidence and clinical characteristics of SARS‐CoV‐2 reinfection in Shanghai, China, we conducted a multicenter cohort study. COVID‐19 patients first infected with BA.2 (March 1, 2022–May 23, 2022) who were quarantined in Huashan Hospital, Renji Hospital, and Shanghai Jing'an Central Hospital were followed up for reinfection from June 1, 2022 to January 31, 2023. Of 897 primary infections, 148 (16.5%) experienced reinfection. Incidence rate of reinfection was 0.66 cases per 1000 person‐days. Female gender (adjusted odds ratio [aOR]= 2.19, 95% confidence interval [CI]: 1.29–3.83) was a risk factor for reinfection. The four most common symptoms of reinfections during the circulation of BA.5 sublineages were cough (62.59%), sore throat (54.42%), fatigue (48.98%), and fever (42.57%). Having received a booster vaccination was not associated with reduced severity of reinfection in comparison with not having received booster vaccination. After matched 1:1 by age and sex, we found that reinfections with BA.5 sublineages had significantly lower occurrence and severity of fever, fatigue, sore throat, and cough, as compared to primary infections with BA.5 sublineages. SARS‐CoV‐2 Omicron reinfections were less severe than Omicron primary infections during the circulation of the same subvariant. Protection offered by both vaccination and previous infection was poor against SARS‐CoV‐2 reinfection.
Increasing connections of the leading internal mode of the summertime Northwest Pacific subtropical anticyclone with preceding ENSO under greenhouse warming in FGOALS‐g3 super‐large ensemble
Authors: Ma Jing , Lin Pengfei , Wang Lu , Zhao Bowen , Xu Haiming 
Published: August 2023

AbstractWhile much progress has been made in understanding how anthropogenic forcing influences the climate mean state, less attention has been paid to how it may modulate the internal variability of air–sea coupled mode. This study investigates forced changes of the leading internal mode of the summertime Northwest Pacific subtropical anticyclone (NWPSA) and the related sea surface temperature (SST) anomalies based on the 110‐member FGOALS‐g3 super‐large ensemble for the period of 1850–2099. The leading internal mode of the NWPSA variability is obtained by applying snapshot‐empirical orthogonal function analyses across the ensemble dimension each year. It is shown that the connection between the NWPSA and the preceding El Niño–Southern Oscillation (ENSO) strengthens in response to anthropogenic forcing, and the precipitation along the northwestern flank of the NWPSA increases correspondingly due to stronger water vapour transport. The SST anomalies corresponding to the change invoke a rapid transition from El Niño to La Niña in a warming world, which induces a zonal SST contrast between the Indian Ocean warming and the equatorial Pacific cooling, favouring a strengthening of the NWPSA. The stronger influence of ENSO on the NWPSA in the ensuing summer under greenhouse warming may result from the pronounced increase in the internal variability of the central deep‐equatorial Pacific SST and precipitation over the western‐central equatorial Pacific in winter. The stronger influence indicates that ENSO may serve as a stronger predictor of the summertime NWPSA in a warming climate, and may improve the skills of the seasonal forecast of the climate over East and South Asia in summer.
Moringa oleifera: a valuable insight into recent advances in medicinal uses and pharmacological activities
Authors: Jikah Agatha Ngukuran , Edo Great Iruoghene 
Published: August 2023

AbstractMoringa oleifera is an important medicinal plant in several countries; for example, Nigeria, the USA, Turkey, Germany, Greece, and Ukraine. The abundant bioactive and nutritional properties of this plant make it useful in many and diverse areas of life, including the health, cosmetic, agricultural, and food industries to mention but a few. Research has found that the presence of proteins, carbohydrates, lipids, vitamins, minerals, flavonoids, phenols, alkaloids, fatty acids, saponins, essential oils, folate, aromatic hydrocarbons, sterols, glucosinolates, and glycosides, among others, characterize the moringa nutrient profile and, as a result, give rise to its remedial effects on ailments such as wounds, stomach and duodenal ulcers, allergies, obesity, diabetes, inflammation, asthma, and so on. It is the aim of this review to provide an insight into such medicinal and pharmacological remedies attributed to moringa, stating both the past and recent discoveries. This review article also takes a look into the botanical features, bioactive compounds, antinutrients, food applications, bacterial fermentation products, biosafety, industrial applications, and other uses of moringa. Finally, with the belief that knowledge is progressive, we acknowledge that there are things yet undiscovered about this wonder plant that will be of value both to medicine and general life; we therefore recommend that research work continues on the moringa plant. © 2023 Society of Chemical Industry.
A repertoire of alginate lyases in the alginate polysaccharide utilization loci of marine bacterium Wenyingzhuangia fucanilytica: biochemical properties and action pattern
Authors: Li Jiajing , Pei Xiaojie , Xue Changhu , Chang Yaoguang , Shen Jingjing , Zhang Yuying 
Published: August 2023

AbstractBACKGROUNDAlginate lyases are important tools for alginate biodegradation and oligosaccharide production, which have great potential in food and biofuel fields. The alginate polysaccharide utilization loci (PUL) typically encode a series of alginate lyases with a synergistic action pattern. Exploring valuable alginate lyases and revealing the synergistic effect of enzymes in the PUL is of great significance.RESULTSAn alginate PUL was discovered from the marine bacterium Wenyingzhuangia fucanilytica CZ1127T, and a repertoire of alginate lyases within it was cloned, expressed and characterized. The four alginate lyases in PUL demonstrated similar optimal reaction conditions: maximum enzyme activity at 35–50 °C and pH 8.0–9.0. The results of action pattern indicated that they were two PL7 endolytic bifunctional enzymes (Aly7A and Aly7B), a PL6 exolytic bifunctional enzyme (Aly6A) and a PL17 exolytic M‐specific enzyme (Aly17A). Ultra‐performance liquid chromatography–mass spectrometry was employed to reveal the synergistic effect of the four enzymes. The end products of Aly7A were further degraded by Aly7B and eventually generated oligosaccharides, from disaccharide to heptasaccharide. The oligosaccharide products were completely degraded to monosaccharides by Aly6A, but it was unable to directly degrade alginate. Aly17A could also produce monosaccharides by cleaving the M‐blocks of oligosaccharide products, as well as the M‐blocks of polysaccharides. The combination of these enzymes resulted in the complete degradation of alginate to monosaccharides.CONCLUSIONA new alginate PUL was mined and four novel alginate lyases in the PUL were expressed and characterized. The four cooperative alginate lyases provide novel tools for alginate degradation and biological fermentation. © 2023 Society of Chemical Industry.
Minimally invasive stabilization of pelvic metastatic bone disease: A review of an emerging technique
Authors: Lee Linus , Brown Anthony , Lerman Daniel M. 
Published: August 2023

AbstractPercutaneous pelvic stabilization is an emerging technique that provides mechanical stability to pathologic fractures of the pelvic ring and acetabulum. Variability exists in procedural technique among institutions; however, early case series consistently demonstrate an acceptable complication profile and significant improvement in patients' pain and function. This minimally invasive approach is less morbid than traditional, open acetabular and pelvic reconstructions. Therefore, this procedure is an encouraging palliative intervention for a growing patient population in need.
Prognostic factors in the primary care of patients with Merkel cell carcinoma: A monocentric cohort study of 108 patients from a tertiary referral centre
Authors: Placke Jan‐Malte , Zahn Maximilian , Zillikens Hannah , Krefting Frederik , Lodde Georg C. , Zimmer Lisa , Livingstone Elisabeth , Hadaschik Eva , Sucker Antje , Roesch Alexander , Tasdogan Alpaslan , Srinivas Nalini K. , Schadendorf Dirk , Becker Jürgen C. , Ugurel Selma 
Published: August 2023

AbstractBackgroundMerkel cell carcinoma (MCC) is one of the deadliest skin cancers. Despite existing national guidelines, treatment of MCC patients is not as well standardized as for more common skin cancers.ObjectivesThe study objective was to investigate factors predisposing to favourable/unfavourable patient outcomes and to which extent guideline‐based care affects patient survival.MethodsThis noninterventional study investigated a monocentre real‐world patient cohort with a histologically confirmed diagnosis of MCC who presented at the skin cancer centre, University Hospital Essen. Patient and tumour characteristics (age, sex, primary localization, Merkel cell polyomavirus [MCPyV], tumour stage at initial diagnosis and primary treatment measures [surgery, radiation]) were correlated with the patient outcome in terms of recurrence‐free survival (RFS) and overall survival (OS).ResultsA total of 108 patients were identified. The median age of the patients was 69.9 years (range 39–88), with patients aged <70 years showing a trend towards a longer RFS (p = 0.192). Regarding sex, 69 (63.9%) of the patients were male, with females showing a trend towards a longer RFS (0.189). MCPyV+ primary tumours are less frequently located in the head/neck region (p = 0.003). Patients with primary tumours in the head/neck region had a significantly worse OS than patients with primary tumours at the trunk/extremities (p = 0.007). Patients with positive sentinel lymph nodes (SLNs) showed a tendency towards shorter RFS (p = 0.126) and OS (p = 0.089). Patients with American Joint Committee on Cancer stages I, IIA and IIB had a slightly better RFS (p = 0.803) and OS (p = 0.820) compared to patients with stages IIIA and IIIB. Moreover, the administration of adjuvant radiotherapy resulted in a slightly better RFS (p = 0.299) and OS (p = 0.276) in patients with tumour stages I, IIA and IIB.ConclusionsIn the present study, the outcome of MCC patients depended on primary tumour localization, SLN status, sex and age. The tumour stage and the adjuvant radiation had only limited effects on patient outcomes.
Organizational knowledge heterogeneity: Between conceptual nuances and the quest for a measure
Authors: El Louadi Mohamed 
Published: August 2023

AbstractThis paper is a survey of relevant empirical literature pertaining to knowledge heterogeneity. Its purpose focuses on highlighting issues surrounding its definition and measurement. First, it shows that knowledge heterogeneity is definitionally close to several other concepts, each measured in a certain way. Second, the same measures have been used indiscriminately for several of these concepts. Third, different measures have been used for the same concepts. The point being made is that comparable empirical results cannot be achieved if the same measures are used for different concepts. Research in knowledge management and innovation management centered around knowledge heterogeneity could be impeded if different emphases are put on different words while studying a concept that is defined similarly across studies yet measured differently, or that is measured similarly despite being defined differently. Results in future research are more likely to converge if knowledge heterogeneity is defined separately from similar concepts such as knowledge sharing and knowledge overlap, for example.
Binocular microscopes versus exoscopes: Experiences and performance in simulated otologic surgery
Authors: Larkin Riley , Langlie Jake , Roldan Luis Pablo , Thielhelm Torin , Mahfood Christopher , Chiossone Juan A. 
Published: August 2023

AbstractObjectivesExoscopes represent a promising alternative to conventional binocular microscopes (OM) in otology offering potential advantages such as enhanced ergonomics and a more compact device design. While previous research has demonstrated the effectiveness of exoscopes in various surgical specialties, their objective assessment in the field of otology remains limited. Therefore, this investigation aims to assess task‐based efficiency associated with exoscopes in the field of otology by use of simulated surgical models.MethodsA prospective cross‐over study design was used to compare an OM to an exoscope in otolaryngology residents and medical students. Participants performed five tasks on 3D‐printed ear models using both the exoscope and OM. Data collection included completion time, frequency of predefined errors, mental effort, and user experience. Subgroup analysis was performed based on level of experience.ResultsFourteen students and fifteen residents participated. Participants completed four of five tasks faster with the OM and there was no difference in number of errors committed. When separated by surgical experience, residents performed four of five tasks faster using the OM while students completed one of five tasks faster with the OM. Students committed more errors with the exoscope for one task with no difference in errors for residents. There was no difference in perceived difficulty performing tasks with either visualization system. Exit survey results showed more favorable opinions of the OM among residents and more favorable opinions of the exoscope among students.ConclusionsThe exoscope permits successful performance in simulated otologic tasks. Task performance and user experience between operative microscopes and exoscopes differ based on level of surgical experience.Level of Evidence2.
A Shear‐Thinning, Self‐Healing, Dual‐Cross Linked Hydrogel Based on Gelatin/Vanillin/Fe3+/AGP‐AgNPs: Synthesis, Antibacterial, and Wound‐Healing Assessment
Authors: Talodthaisong Chanon , Patramanon Rina , Thammawithan Saengrawee , Lapmanee Sarawut , Maikaeo Lamai , Sricharoen Phitchan , Khongkow Mattaka , Namdee Katawut , Jantimaporn Angkana , Kayunkid Navaphun , Hutchison James A. , Kulchat Sirinan 
Published: August 2023

AbstractA shear‐thinning and self‐healing hydrogel based on a gelatin biopolymer is synthesized using vanillin and Fe3+ as dual crosslinking agents. Rheological studies indicate the formation of a strong gel found to be injectable and exhibit rapid self‐healing (within 10 min). The hydrogels also exhibited a high degree of swelling, suggesting potential as wound dressings since the absorption of large amounts of wound exudate, and optimum moisture levels, lead to accelerated wound healing. Andrographolide, an anti‐inflammatory natural product is used to fabricate silver nanoparticles, which are characterized and composited with the fabricated hydrogels to imbue them with anti‐microbial activity. The nanoparticle/hydrogel composites exhibit activity against Escherichia coli, Staphylococcus aureus, and Burkholderia pseudomallei, the pathogen that causes melioidosis, a serious but neglected disease affecting southeast Asia and northern Australia. Finally, the nanoparticle/hydrogel composites are shown to enhance wound closure in animal models compared to the hydrogel alone, confirming that these hydrogel composites hold great potential in the biomedical field.
Carleson measures on convex domains with smooth boundary of finite type
Authors: Li Haichou , Liu Jinsong , Wang Hongyu 
Published: August 2023

AbstractFollowing M. Abate and A. Saracco's work on strongly pseudoconvex domains in , we characterize Carleson measures of in bounded convex domains in with smooth boundary of finite type. We also give examples of Carleson measures with uniformly discrete (with respect to the Kobayashi distance) sequences.
Ternary Organic Solar Cells with Power Conversion Efficiency Approaching 15% by Fine‐Selecting the Third Component
Authors: Chang Meijia , Zhang Chenyang , Li Na , Wang Cong , Sui Dong , Wang Fang , Wang Yinxia , Wang Yonggang , Wu Haitao , Meng Lingxian 
Published: August 2023

AbstractNonfullerene acceptors with mediate bandgap play a crucial role in ternary devices as the third component, further boosting the performance of organic solar cells (OSCs). Herein, three F‐series acceptors (F‐H, F‐Cl, and F‐2Cl) with mediate bandgap are selected and introduced into the PM6:BDT‐Br binary system as third component to find the detailed influence of end groups with chlorine (Cl) atom substitution on the performance of ternary organic solar cells. Due to the increased substitution of Cl atoms on the end groups, F‐Cl and F‐2Cl as guest acceptors reveal a superior ability to regulate the morphology of blend films, contributing to the ordered packing properties and high crystallinity. As a result, F‐Cl and F‐2Cl based ternary OSCs achieve significantly improved PCEs of 13.89% and 14.67%, respectively, compared with the binary devices (12.70%). On the contrary, F‐H without Cl atom displays a poor compatibility with the host system, resulting in an inferior ternary device with a low PCE of 10.79%. This work indicates that F‐series acceptors with mediate bandgap are a promising class of third component for high‐performance ternary OSCs. And introducing more Cl atoms substitution on the end groups, especially F‐2Cl, will own a broad applicability for other binary devices.