bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ligand-induced cold activation of TRPV3
Authors: Wang Guangyu 
Published: January 2025

Abstract

Both hot and cold sensation of the homotetrameric thermosensitive transient receptor potential vanilloid 1–4 (TRPV1-4) channels have been predicted by a single Gibbs-Helmholtz equation for a change in molar heat capacity. However, cold activation has not been confirmed for those heat-responsive TRPV1-4 channels. Given the cooperative heat unfolding and non-cooperative cold unfolding behaviors in proteins, two different open states at low and high temperatures should be detected in TRPV1-4 channels. To test this hypothesis, the temperature-dependent quaternary and tertiary structures of oxidized TRPV3 in the presence and absence of the natural cannabinoid tetrahydrocannabivarin (THCV) were characterized along a lipid-dependent minimal gating pathway. Further thermoring analyses showed that gating state-dependent thermostability allowed oxidized TRPV3 to be activated and then inactivated only below 30°C. However, no inactivation would be observed above 30°C once the lipid at the active vanilloid site was released by THCV binding. Therefore, such two temperature-dependent gating pathways of oxidized TRPV3 actually resulted from cold and heat activation. (161 words)
WITHDRAWN: Effect of pulse pests infestation sensitivity and ozone control on seed quality characteristics
Authors: Zinhoum Rasha A. , Omran Azza A. , Ebian Eman F. , Kassem Enas M.K. 
Published: January 2025

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Vesuvianite as a key tool for the reconstruction of skarn formation conditions: An example from the Sauce Chico Complex, Argentina
Authors: Justiniano Carlos A. Ballivián , Rodríguez Maricel G. , Panikorovskii Taras L. , Benítez Manuela E. , Recio Clemente , Ramos Cinthia P. , Lanfranchini Mabel E. , Di Salvo Florencia 
Published: January 2025

Abstract
In the Sauce Chico Complex (Neoproterozoic-middle Cambrian age; Ventania System, Argentina), polymetamorphosed carbonate xenoliths known as the Loma Marcelo skarn are hosted in an Ediacaran peraluminous granite. The skarn has three types of vesuvianite, namely a, b and c, with different colors, habits, and/or mineral assemblages. They were studied through petrographic microscopy, electron microprobe, inductively-coupled mass and atomic emission spectrometry, Raman and Mössbauer spectroscopy, X-ray (powder and single crystal) diffraction, and fluid inclusions and stable isotope analyses. The averaged composition of the Loma Marcelo skarn vesuvianite is XCa19.00Y(Al9.57Fe2+1.29Fe3+0.50Mg1.17Ti0.48Mn2+0.04)Σ = 13.05T□Z(Si18O68)W(OH5.79F3.03Cl0.28O0.90)Σ = 10.00 and corresponds to vesuvianite sensu stricto. Negligible amounts of XNa and TB were detected. Only Zn, Sr, Ce, La, and Sn are in concentrations &gt;50 ppm. Through single-crystal XRD, the crystal structure of vesuvianite types a and b was refined in the P4/nnc space-group (domains with P4/n symmetry are also present). Type c vesuvianite could not be satisfactorily refined; however, a P4/n symmetry is suspected. By comparing the Loma Marcelo skarn vesuvianite cell parameters with those from other vesuvianites worldwide, it becomes clear that the symmetry does not influence such parameters. Based on Raman, single-crystal XRD data, and structural and chemical characteristics, formation temperatures of 550 °C (type b), 450 °C (type a), and 300–400 °C (type c) were estimated. δ18OH2O values of ca. +11.9‰ calculated for these temperatures from δ18O values determined on vesuvianite concentrates and the vesuvianite-water fractionation factors are compatible with a peraluminous granitic source. According to this, the Loma Marcelo skarn vesuvianite appear to reflect a retrograde process related to the crystallization of the Ediacaran granite hosting the metasomatized xenoliths. During a subsequent protracted Permian tectono-metamorphic event, biphasic secondary fluid inclusions were trapped at ca. 270–339 °C (ca. 250 MPa) from low salinity metamorphic fluids. Stable isotope determinations of H and O on vesuvianite concentrates indicate that the interaction with magmatic and metamorphic aqueous fluids promoted modifications in the 2H/1H ratios of the hydroxyl groups from the W sites, whereas the 18O/16O ratios of the silicate groups were not substantially modified. Notably, the vesuvianite structure is highly stable, remaining unchanged after formation. This stability suggests vesuvianite-group minerals could serve as a reliable XRD-based thermometer.
The influence of agricultural planting in rural landscape design and tourism development — A case of Shandong Yinshi Village
Authors: Bai Jie , Johar Suhana Binti , Mohammad Noraziah Binti 
Published: January 2025

Within the framework of China's rural revitalization strategy, there is a notable positive trend in rural construction and development across various regions, accompanied by a burgeoning interest in rural tourism development. This paper focuses on Yinshi Village in Linqu County, Shandong Province, examining how the village capitalizes on its persimmon industry to shape, design, and advance tourism development within its rural landscapes. The results of this study illustrate that the persimmon industry plays a pivotal role in diversifying rural landscapes, improving the overall planning and design of rural areas, enhancing the attractiveness of rural tourism, and boosting the economic prosperity of the local population. This research contributes valuable development strategies for integrating agricultural planting into rural landscape design and tourism development. Moreover, it investigates the substantial influence of agricultural planting on both rural landscape design and tourism development, ultimately providing insights and experiences that are applicable not only in China but also in similar regions globally.
The impact of Cognitive Behavioral Therapy (CBT) program on anxiety disorder and memory recall
Authors: Al-Habies Feras Ali Mohammad , Tarawneh Hussein , Al Dalaeen Issam Duhelan Abed Al Nabi , Tarawneh Haya Hussien , Dawaghreh Sawsan Adnan , Jawarneh Abedalraheem Ismail Ahmad , Al-Ja’afreh Somaya Abdel-Hameed Ateeq , Alorani Omar Ismail Hamzeh 
Published: January 2025

The efficient treatment of anxiety-related disorders and memory recall is significant, regarding the occurrence of these disorders and their relationship with poor psychology operational. Thus, this study aims to measure the modern evidence on the efficacy of CBT on anxiety- disorders and memory recall in elderly in Amman, Jordan. Quasi-experimental intervention was conducted combined with qualitative approach. Purposive sampling method was used to sample 46 elderly resident in Amman. Feedback and observation were used to collect qualitative data. The tests of “The State-Trait Anxiety Inventory” (STAI), “Rey Auditory Verbal Learning Test” (RAVLT), and Narrative Recall Assessment (NRA) were used to collect the data. SPSS 25.0 and NVivo software analyzed the data. The findings show that the Cognitive Behavioral Therapy program has a positive effect on anxiety decreasing, memory function and recalling in elderly people. Three major themes emerged “improved coping, increased confidence, positive engagement”. The positive findings highlight the importance of personalized CBT interventions in improving mental health among elderly people residing within an institutionalized care setting. The study contributions, recommendations, and future directions were explained at the end of the study.
From traditional finance to neurofinance: Literature review
Authors: Faris Ali Ahmed , Jwan Hayder Khudhair , Al-Bidairi Karrar Hatam Attieh 
Published: January 2025

The research aims to study a new branch to financial decision-making called neuro-finance, as it provides an another explanation for the failure of behavioral finance, which came recently in research and studies as a new way to analyze the factors that have a role in financial decision, One of the objectives of this research is to develop a systematic review based on many published papers and articles on neurofinance to organize the main ideas and issues that have addressed the neurophysiological links of financial choices. After reviewing many studies on neurofinance, we conclude that researchers debate about neurofinance in the early stages, but the results reached by most researchers are that neurofinance is of wide interest by researchers in financial management, and this research is important not only for reviewing previous studies, but rather a guide to assist researchers and scholars interested in this topic by collecting and analyzing previous studies.
Effectiveness of internal control in green credit: Influential factors in Vietnam's commercial banking sector
Authors: Nguyen Tan Huu , Nguyen Binh Van , Nguyen Thuong Thu , Luu Duc Huu 
Published: January 2025

This study investigates the effectiveness of internal controls governing green credit operations in Vietnamese commercial banks. We employ regression analysis to identify key factors influencing control effectiveness. Six key areas emerge: Risk Management, Macroeconomic Factors, Monitoring Activities, Group Benefits, Work Motivation, and Information and Communication. Independent sample T-tests and one-way ANOVA tests reveal significant variations in control effectiveness based on employee age groups and positions within the banks. Further analysis categorizes these factors into strong and weak impact groups based on their Beta coefficients. Risk Management and Macroeconomic Factors emerge as strong influencers, highlighting the critical role of robust risk management practices and favorable economic conditions. Conversely, Monitoring Activities, Group Benefits, Information and Communication, and Work Motivation have weaker but still notable impacts, suggesting areas for improvement in internal supervisory practices, communication systems, and employee motivation strategies. The findings underscore the critical role of risk management and macroeconomic factors while highlighting opportunities for enhancing supervisory practices, internal communication, and employee motivation within Vietnamese commercial banks.
Auranofin-loaded PLGA Nanoparticles for Neuroprotection against Aluminium-induced Alzheimer’s Disease
Authors: Kushwaha Shiv Kumar , Ashawat Mahendra Singh , Arora Rimpi , Baldi Ashish 
Published: January 2025

Aim:
The aim of the current study was to explore nano-formulation for effective neuroprotection by
auranofin.

Background:
Currently, the treatment options for various CNS disorders, particularly neurodegenerative disorders,
are greatly constrained. A significant obstacle in this pursuit is the blood-brain barrier, a shielding covering
that hinders the route of numerous biochemical treatments into the brain. To overcome this problem, nanoformulation-
based approaches are gaining interest, increasing the compound's BBB penetrability.

Objective:
The objective of this study was to evaluate whether nanoparticles fabricated from poly(lactic-co-glycolic
acid) encapsulated with auranofin could oppose aluminium chloride-induced Alzheimer's disease

Method:
Auranofin-encapsulated PLGA nanoparticles were prepared, and their particle size, Entrapment Efficiency
(EE), distribution of particles, morphological surface charge, and structural characteristics were characterized.
During the in vivo study, rats were orally administered AlCl3 at 100 mg/kg for 21 days. Meanwhile, auranofin
and auranofin nanoparticles were orally administered at doses of 5 and 10 mg/kg and 2.5 and 5 mg/kg,
respectively, within 2 weeks. After the course therapy, the rats were decapitated, and the hippocampus was collected
for the estimated biochemical and neuroinflammatory markers.

Results:
The auranofin nanoparticles were characterized, revealing % entrapment efficiency (98%) and % loading
dose (76%). The nanoparticles exhibited a morphological surface charge of 27.5 ± 5.10 mV, a polydispersity
index of 0.438 ± 0.12, and a mean particle size of 101.5 ± 10.3 nm. In the in vivo study, administering a
gold compound (auranofin) and formulation (auranofin nanoparticles) resulted in a significant improvement in
cognitive deficits, changes in biochemical parameters, and markers of neuroinflammation triggered with aluminium
chloride.

Conclusion:
The results have suggested that auranofin nanoparticles demonstrate abilities to protect neurons
compared to auranofin alone. The noticed therapeutic benefits of the auranofin-encapsulated PLGA nanoparticles
can be attributed to modulation in particle size with antioxidative and anti-inflammatory impacts of auranofin.
Consequently, the outcome of the research has revealed that gold compound nanoparticles hold the potential
to be a promising option for altering the therapeutic course of Alzheimer's disease.
Evaluation of the Therapeutic Potential of the Methanolic Extract and Fractions of Datura stramonium in Paracetamol-intoxicated Rabbits
Authors: Attaullah Mohammad , Ul Haq Hussain , Khan Abdullah , Ahmad Bashir , Alhegaili Alaa , Hamayun Muhammad , Ali Sajid 
Published: January 2025

Introduction:
Datura stramonium (DS) possesses strong medicinal and therapeutic potential but
has been rarely evaluated in this context.

Methods:
The present study was intended to evaluate the antioxidant, hepatoprotective, and nephroprotective
potential of the crude methanolic leaf extract and ethyl acetate, chloroform, n-hexane, and aqueous fractions
of DS in paracetamol-intoxicated rabbits. Paracetamol (2 g/Kg BW) was applied to induce liver and kidney
injury in rabbits while the methanolic extract and fractions of DS were applied in the dose range of 150
mg/Kg to 300 mg/Kg body weight for 21 days. Histopathology of the liver, and kidney and analysis of ALT
(Alanine Transaminase), ALP (Alkaline Phosphatase), total bilirubin, serum urea, serum creatinine, and serum
uric acid were carried out. In-vitro antioxidant potential of the extract and fractions of DS was carried out
through DPPH (1,1-diphenyl 2-picrylhydrazyl) free radical scavenging assays.

Results:
The hepatoprotective and nephroprotective potential of the extract and fractions of DS at the dose
level of 300 mg/Kg BW was highly significant (P ˂ 0.01). ALT was found elevated in the paracetamol-treated
group (117.3 ± 1.61 U/L) compared to the group treated with methanolic extract of DS, (57.3 ± 0.87 U/L) and
normal control group (60.6 ± 1.58 U/L) at 300 mg/kg BW. Elevated levels of ALP (120 ± 1.58 U/L) and Bilirubin
(1.6 ± 0.32 mg/dl) were found in the paracetamol-treated group compared with the group treated with
methanolic extract of DS (67.5 ± 1.35 U/L; 0.2 ± 1.0 mg/dl) and normal control group (70.1 ± 1.53 U/L; 0.4 ±
0.16 mg/dl) respectively at 300 mg/kg BW. The methanolic extract of DS produced a marked scavenging activity
of the DPPH free radicals (88.2 ± 0.006 %) followed by the fractions of DS compared to ascorbic acid
(95.5 + 0.003 %) at a concentration of 1000 μg/ml. The effects were comparable to those produced by ascorbic
acid. Liver and kidney histology of the rabbits treated with extract, fractions, and ascorbic acid of DS
caused reductions in the pathological features compared to the paracetamol-treated animals. The histological
observations and chemical pathological alterations demonstrated the significant hepatoprotective and nephroprotective
benefits of the DS extract and its fractions.

Conclusion:
It has been concluded that the methanolic extract and fractions of DS possess antioxidant, hepatoprotective,
and nephroprotective properties in paracetamol-intoxicated rabbits.

conclusion:
It has been concluded that the methanolic extract and fractions of DS possess strong antioxi-dant, hepatoprotective, and nephroprotective potential
in paracetamol-intoxicated rabbits.
Biotechnological Perspectives on the Therapeutic Potential of Phenylpropanoid Cinnamaldehyde in Inflammatory Diseases: Signaling Pathways
Authors: Oliveira Sousa Ian Jhemes , Nogueira Kerolayne De Melo , Oliveira Rita de Cássia Meneses 
Published: January 2025

Abstract:
The traditional use of plants of the Cinnamomum genus dates back to traditional
Eastern medicine for millennia and they have also been used in Western integrative medicine
practices, especially for their anti-inflammatory activity. In the context of chemical diversity,
the absolute majority of species in this genus have cinnamaldehyde as the majority component,
which in turn holds the title of the active ingredient, whose biological effect profile has
already been demonstrated in numerous experiments in acute and chronic inflammatory conditions.
In this context, the objective of this research was to investigate how cinnamaldehyde
can influence inflammatory phenomena. To this end, the data search was carried out in Pub-
Med, SciELO, and LILACS databases using the following descriptors: "cinnamaldehyde OR
cinnamaldehyde" and "inflammation". Next, the methodological quality of the selected articles
was checked, excluding repeated studies, which were purely in silico and not relevant to the
construction of this research. The findings showed cinnamaldehyde to modulate the inflammatory
response by inhibiting pro-inflammatory mediators and important signaling trajectories,
including NF-κB, NLRP3 inflammasome, TGF-β/Smads, and the NRF2/ARE antioxidant
pathway. Cinnamaldehyde's scope of investigation also involves aspects of translational science,
exhibiting therapeutic effects in human models, which suggests that it may have clinical
relevance. The data support that cinnamaldehyde is a promising candidate for development as
a treatment in inflammatory pathologies.
Association between Sputum Culture Conversion and Body Mass
Index among Multidrug-Resistant Tuberculosis Patients in Punjab,
Pakistan: A Multicenter Retrospective Study
Authors: Akhtar Abdul Majeed , Khan Iqra Hamid , Shah Fatima Iftikhar , Kanwal Shamsa , Majeed Sufia , Ullah Najeeb , Shehzadi Somia , Ullah Asmat 
Published: January 2025

Background:
The global challenge of Multidrug-resistant Tuberculosis
(MDR-TB) presents a substantial public health concern, requiring extended and
complex treatment regimens. Understanding the factors impacting treatment results,
particularly sputum culture conversion and Body Mass Index (BMI), is crucial. This
retrospective cohort investigation conducted in Punjab, Pakistan, sought to explore the
correlation between BMI and sputum culture conversion in individuals diagnosed with
MDR-TB.

Material and Methodology:
Data from 2663 confirmed MDR-TB patients across
multiple Programmatic Management of Drug-Resistant Tuberculosis PMDT sites in
Punjab, Pakistan, were retrospectively analyzed. Demographic and clinical
characteristics, BMI, comorbidities, previous TB treatments, and drug resistance were
evaluated. Cox proportional hazards regression models were employed to assess the
association between time to sputum culture conversion and patient characteristics

Results:
The study compared MDR-TB treatment outcomes based on BMI categories
(≥18.5 vs. <18.5 Kg/m^2). It involved 1626 employed patients, with a mean age of 33 ±
15 years, displaying baseline body weights averaging 48±7 kg (normal weight) and
37±6 kg (underweight). On average, sputum culture conversion occurred at four
months, with approximately 37% achieving conversion within this period. Among
several factors studied, the univariate analysis identified BMI <18.5 Kg/m^2, prior firstline drug treatment, and comorbidities as significantly associated with failure to achieve
sputum culture conversion within 6 months. In multivariate analysis, the inability to
achieve conversion was notably linked to BMI <18.5 Kg/m^2, previous first-line drug
treatment, and resistance to fluoroquinolone drugs

Conclusion:
This study provided valuable insights into sputum culture conversion,
BMI, and drug resistance among MDR-TB patients. While around half of the patients
achieved sputum culture conversion within six months, factors, such as comorbidities,
previous TB treatment, and drug resistance, significantly influenced treatment
outcomes
Mechanism of Ginkgo biloba Extract in the Treatment of Tinnitus Based on Network Pharmacology
Authors: Huang Qiao , Hou Tao , Ren Yi , Liao Xingwei , Du Kejiang , Yin Shihua 
Published: January 2025

Objective:
This study aimed to examine the active constituents and therapeutic targets of
Ginkgo biloba extract (GBE) through a network pharmacology methodology to elucidate the mechanisms
underlying the efficacy of GBE in treating tinnitus.

Methods:
The active constituents and potential targets of GBE were identified via the Traditional
Chinese Medicine Systems Pharmacology (TCMSP) database, while tinnitus-related targets were
sourced from the GeneCards database. Protein-protein interaction (PPI) data relevant to tinnitus were
retrieved from the STRING database. Subsequently, an active constituent-target network was constructed,
and Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes
(KEGG) pathway analyses were conducted using Cytoscape 3.7.1.

Results:
The analysis identified 27 active constituents and 73 potential therapeutic targets of GBE
relevant to tinnitus treatment. A total of 418 GO terms were identified, including 408 biological processes,
4 cellular components, and 6 molecular functions, which were associated with processes,
such as cell cycle regulation, apoptosis, inflammatory response, oxidative stress, and angiogenesis.
Additionally, 116 KEGG pathways were identified, including pathways involved in cancer, the
AGE-RAGE signaling pathway in diabetic complications, human cytomegalovirus infection, and
apoptosis, among others.

Conclusion:
The treatment of tinnitus with GBE may target several potential therapeutic candidates,
including MYC, TNF, AKT1, CXCL8, CASP3, IL6, TP53, VEGFA, PTGS2, EGFR, EGF, JUN,
ESR1, MMP9, CCND1, and MAPK1. This approach may involve various mechanisms, such as antiinflammatory,
antioxidant, and anti-apoptotic pathways. Network pharmacology provides a robust
framework for further investigation into the pharmacological targets and molecular mechanisms
through which GBE may exert its effects in the context of tinnitus.
Promising Anticancer Activity of Pyrazole Compounds against Glioblastoma Multiforme: Their Synthesis, In vitro, and Molecular Docking Studies
Authors: Nalcı Kemal Alp , Mete Cihat , Demir Zeynep , Bildirici İshak , Cetin Adnan 
Published: January 2025

Background:
Glioblastoma Multiforme (GBM), a highly aggressive and prevalent brain
cancer with a higher incidence in males, has limited treatment success due to drug resistance, inadequate
targeting and penetration of cancer cells, and an incomplete understanding of its molecular
pathways. GBM is a highly aggressive brain cancer with limited treatment options. This study investigates
the anticancer potential of synthesized pyrazole compounds against GBM cells.

Methods:
A series of pyrazole derivatives were synthesized and tested for their efficacy against
GBM using MTT assays. Molecular docking studies were conducted to explore the binding interactions
of these compounds with GBM receptors.

Results:
Compounds 3 and 5 demonstrated significant anticancer activity, reducing cell viability
more effectively than the control group. MTT assay results confirmed their potency. Molecular
docking studies revealed strong binding interactions with GBM receptors, highlighting their potential
as anticancer agents.

Conclusion:
The study evaluated the anticancer activity of synthesized compounds on human
GBM cells, with compounds 3 and 5 showing the most promising results. Pyrazole 3 significantly
reduced cell viability at high concentrations, while both pyrazoles 3 and 5 required higher doses to
achieve substantial effects, as indicated by their IC50 values. Molecular docking studies confirmed
strong binding interactions with the GBM receptor, and the pharmacokinetic properties suggest
their potential as anticancer agents. These results highlight compounds 3 and 5 as candidates for
further investigation.