bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bony Remodeling of Adolescent Displaced Clavicle Fractures: A FACTS Study
Authors: Pennock Andrew T. , Bastrom Tracey P. , Boutelle Kelly E. , Carroll Alyssa N. , Edmonds Eric W. , Nepple Jeffrey J. , Polinsky Samuel G. , Spence David D. , Perkins Crystal , Willimon Samuel C. , Bae Donald S. , Busch Michael T. , Ellis Henry B. , Hergott Katelyn , Kocher Mininder S. , Li Ying , Pandya Nirav K. , Sabatini Coleen S. , Wilson Philip L. ,   FACTS Study Group, Heyworth Benton E. 
Published: February 2023

Background: Bony remodeling of displaced clavicle fractures in adolescents remains poorly understood. Purpose: To evaluate and quantify clavicle remodeling in a large population of adolescents with completely displaced fractures, which were treated nonoperatively, to better understand the factors that may influence this process. Study Design: Case series; Level of evidence, 4. Methods: Patients were identified from the databases of a multicenter study group investigating the functional outcomes of adolescent clavicle fractures. Patients between the ages of 10 and 19 years with completely displaced middiaphyseal clavicle fractures that were treated nonoperatively and who had further radiographic imaging of the affected clavicle at a minimum of 9 months from initial injury were included. Fracture shortening, superior displacement, and angulation were measured on the injury and final follow-up radiographs using previously validated techniques. Furthermore, fracture remodeling was classified as complete/near complete, moderate, or minimal, using an original classification system found to have good to excellent reliability (interobserver reliability = 0.78, intraobserver reliability = 0.90). Classifications were subsequently analyzed quantitatively and qualitatively to determine the factors associated with deformity correction. Results: Ninety-eight patients (mean age, 14.4 ± 2.0 years) were analyzed at a mean radiographic follow-up of 3.4 ± 2.3 years. Fracture shortening, superior displacement, and angulation significantly improved during the follow-up period by 61%, 61%, and 31%, respectively ( P < .001). Furthermore, while 41% of the population had initial fracture shortening >20 mm at final follow-up, only 3% of the cohort had residual shortening >20 mm. Fracture remodeling was found to be associated with follow-up time; those with longer follow-up time demonstrated more remodeling ( P = .001). Eighty-five percent of patients aged <14 years and 54% of patients aged ≥14 years at time of injury with a minimum follow-up of 4 years underwent complete/near-complete remodeling. Conclusion: Significant bony remodeling occurs in adolescent patients with completely displaced clavicle fractures, including older adolescents, and appears to continue over longer time intervals, even beyond the adolescent years. This finding may help explain the low rate of symptomatic malunions in adolescents, even in severely displaced fractures, and particularly when compared with rates reported in adult studies.
Role of IVIg in Severe Neonatal Jaundice due to Isoimmunization A Retrospective Cohort Study
Authors: Sharma Preeti , Bhatti Anuj , Bakshi Vasundhara 
Published: February 2023

Aim To see the efficacy of intravenous immunoglobulin (IVIg) in reducing the need for exchange transfusion (ET) in neonates with isoimmune hemolytic disease with serum bilirubin at or above exchange level. Methods Retrospective cohort study conducted in neonatal intensive care unit of a tertiary care center from March 2015 to February 2020 included neonates with gestational age ≥35 weeks with positive Direct Coombs Test with serum bilirubin at or above exchange level according to American Academy of Pediatrics charts with no bilirubin encephalopathy at presentation. Study subjects were followed till discharge. Results ET was prevented in 8/41 (19.5%) cases who received IVIg initially vs. 2/51 cases (3.92%) who didn’t ( P = .02, relative risk: 1.98 with 95% confidence interval [1.32-2.98] with number needed to treat: 2.51). Total duration of phototherapy was significantly lesser in those receiving IVIg ( P < .0001). Conclusion Targeted use of IVIg in isoimmune hemolytic disease of newborn with serum bilirubin rising despite intensive phototherapy or within 2 to 3 mg/dL of the exchange level is more likely to benefit than harm and remain prudent.
The parable of the Therapeutic Goods Administration approval of esketamine (Spravato) in Australia
Authors: Lugg William 
Published: February 2023

Objective To review the sequence of events that led to the Therapeutic Goods Administration (TGA) approval of esketamine in Australia, and to explore the potential ethical and clinical consequences of it. Conclusions Trust in the TGA is of paramount importance to Australian psychiatrists. The approval of esketamine raises serious questions about the processes, independence and authority of the TGA, and therefore the confidence Australian psychiatrists can have in the ‘quality, safety and efficacy’ of the drugs they offer their patients.
Evaluation of Response to High-Dose Intravenous Vitamin K Administration
Authors: Chapman April R. , Yerke Jason R. , Lumpkin Mollie , Rudoni Michael A. , Militello Michael , Wang Lu , Bass Stephanie N. 
Published: February 2023

Background: Essential to the coagulation pathway, vitamin K (phytonadione) is used to correct clotting factor deficiencies and for reversal of warfarin-induced bleeding. In practice, high-dose intravenous (IV) vitamin K is often used, despite limited evidence supporting repeated dosing. Objective: This study sought to characterize differences in responders and nonresponders to high-dose vitamin K to guide dosing strategies. Methods: This was a case-control study of hospitalized adults who received vitamin K 10 mg IV daily for 3 days. Cases were represented by patients who responded to the first dose of IV vitamin K and controls were nonresponders. The primary outcome was change in international normalized ratio (INR) over time with subsequent vitamin K doses. Secondary outcomes included factors associated with response to vitamin K and incidence of safety events. The Cleveland Clinic Institutional Review Board approved this study. Results: There were 497 patients included, and 182 were responders. Most patients had underlying cirrhosis (91.5%). In responders, the INR decreased from 1.89 at baseline (95% CI = [1.74-2.04]) to 1.40 on day 3 (95% CI = [1.30-1.50]). In nonresponders, the INR decreased from 1.97 (95% CI = [1.83-2.13]) to 1.85 ([1.72-1.99]). Factors associated with response included lower body weight, absence of cirrhosis, and lower bilirubin. There was a low incidence of safety events observed. Conclusions: In this study of mainly patients with cirrhosis, the overall adjusted decrease in INR over 3 days was 0.3, which may have minimal clinical impact. Additional studies are needed to identify populations who may benefit from repeated daily doses of high-dose IV vitamin K.
Which hematology/oncology patients are high priority for ambulatory clinical pharmacist review? A three-round Delphi survey by the National Comprehensive Cancer Network
Authors: Booth Jennifer P , Kennerly-Shah Julie M , Kelley Lindsey R , Capozzi Donna , Prescott Hillary A , Soefje Scott A , Pace Makala B , Barbour Sally Y , Tizon Ricky F , DeVincenzo Sarah , Carnes Cynthia A , Neidecker Marjorie V 
Published: February 2023

Introduction Prioritization and acuity tools have been leveraged to facilitate targeted and efficient clinical pharmacist interventions. However, there is a lack of established pharmacy-specific acuity factors in the ambulatory hematology/oncology setting. Therefore, National Comprehensive Cancer Network's Pharmacy Directors Forum conducted a survey to establish consensus on acuity factors associated with hematology/oncology patients that are high priority for ambulatory clinical pharmacist review. Methods A three-round electronic Delphi survey was conducted. During the first round, respondents were asked an open-ended question to suggest acuity factors based on their expert opinion. Respondents were then asked in the second round to agree or disagree with the compiled acuity factors, in which those with ≥75% agreement were included in the third round. The final consensus was defined as a mean score ≥3.33 on a modified 4-point Likert scale (4 = strongly agree, 1 = strongly disagree) during the third round. Results A total of 124 hematology/oncology clinical pharmacists completed the first round of the Delphi survey (invitation response rate, 36.7%), of which 103 completed the second round (response rate, 83.1%) and 84 the third round (response rate, 67.7%). A final consensus was achieved for 18 acuity factors. Acuity factors were identified in the following themes: antineoplastic regimen characteristics, drug interactions, organ dysfunction, pharmacogenomics, recent discharge, laboratory parameters, and treatment-related toxicities. Conclusions This Delphi panel of 124 clinical pharmacists achieved consensus on 18 acuity factors that would identify a hematology/oncology patient as a high priority for ambulatory clinical pharmacist review. The research team envisions incorporating these acuity factors into a pharmacy-specific electronic scoring tool.
Executive Functions Contribute to the Differences Between ADHD and Sluggish Cognitive Tempo (SCT) in Adults
Authors: Godoy Victor Polignano , Serpa Alexandre Luiz de Oliveira , Fonseca Rochele Paz , Malloy-Diniz Leandro Fernandes 
Published: February 2023

Objectives: This paper analyses the relationship between sociodemographic variables, executive dysfunctions, Sluggish Cognitive Tempo (SCT) and the mainly dimensions of ADHD: hyperactivity-impulsivity (ADHD-H/I) and inattention (ADHD-IN) in Brazilian adults. Method: A cross-sectional, exploratory, and comparative design was used. A total of 446 participants (295 women) aging from 18 to 63 years old ( M = 3,499 years, SD = 10.7) were recruited on the internet. Correlations, t independent tests and regressions were conducted. Results: Higher scores in ADHD dimensions were associated to more executive functioning problems and time perception distortions in comparison to those participants without significant ADHD symptoms. However, ADHD-IN dimension as well as SCT were higher associated with these dysfunctions than ADHD-H/I. The regression results showed that ADHD-IN was more related to Self-Management to time while ADHD-H/I to Self-Restraint and SCT to Self-Organization/Problem Solving. Conclusion: This paper contributed to the distinction between SCT and ADHD in adults in important psychological dimensions.
Investigation of viscoelastic properties in composite sandwich panels subjected to low-velocity impact: Experimental and numerical approaches
Authors: Hosseinkhani Milad , Ghavami Hamed , Haghighi-Yazdi Mojtaba , Mosavi Mashhadi Mahmoud , Safarabadi Majid 
Published: February 2023

This study investigates the effect of viscoelastic properties in the numerical modeling of foam-filled sandwich panels when their composite facesheets are exposed to low-velocity impact loading. A finite element (FE) model is developed using the software package of ABAQUS and used to investigate the effect of both considering and ignoring the time-dependent behavior of composite laminate facesheets as well as the foam core. Material constitutive equations, damage characteristics, and failure modes are defined in a FORTRAN user-subroutine VUMAT. To characterize the material behavior of both polyurethane foam and glass/epoxy composite material, a set of experimental tests are conducted under compression, tension, and stress relaxation modes. To validate the numerical results, low-velocity impact tests at two energy levels of 9.81 and 17 joules are carried out on sandwich panels with foam core. The results of numerical simulations are found to be in good agreement with the experimental test results. It is shown that ignoring the viscoelastic properties in the composite laminate and the foam core can lead to deviations of up to 7% and 25%, respectively, from experimental results. The analysis reveals that, ignoring the viscoelastic behavior along the fiber-direction in the composite facesheets does no change the results considerably. The viscoelastic properties perpendicular to the fibers, however, has a more noticeable effect on the results due to the prevalence of the properties of the polymeric resin in that direction.
Seizure risk in multiple sclerosis patients treated with disease-modifying therapy: A systematic review and network meta-analysis
Authors: Dang Yew Li , Yong Vivien TY , Sharmin Sifat , Perucca Piero , Kalincik Tomas 
Published: February 2023

Background: Multiple sclerosis patients experience 3–6 times more seizures than the general population, but observations vary among studies. Seizure risk in disease-modifying therapy recipients remains unknown. Objective: The objective of this study was to compare seizure risk in multiple sclerosis patients receiving disease-modifying therapy versus placebo. Methods: MEDLINE(OVID), Embase, CINAHL, and ClinicalTrials.gov were searched from database inception until August 2021. Phase 2–3 randomized, placebo-controlled trials reporting efficacy and safety data for disease-modifying therapies were included. Network meta-analysis followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, using Bayesian random effects model for individual and pooled (by drug target) therapies. Main outcome was loge seizure risk ratios [95% credible intervals]. Sensitivity analysis included meta-analysis of non-zero-event studies. Results: A total of 1993 citations and 331 full-texts were screened. Fifty-six included studies (29,388 patients—disease-modifying therapy = 18,909; placebo = 10,479) reported 60 seizures (therapy = 41; placebo = 19). No individual therapy was associated with altered seizure risk ratio. Exceptions were daclizumab (−17.90 [−65.31; −0.65]) and rituximab (−24.86 [−82.71; −1.37]) trending toward lower risk ratio; cladribine (25.78 [0.94; 4.65]) and pegylated interferon-beta-1a (25.40 [0.78; 85.47]) trended toward higher risk ratio. Observations had wide credible intervals. Sensitivity analysis of 16 non-zero-event studies revealed no difference in risk ratio for pooled therapies (l0.32 [−0.94; 0.29]) Conclusion: No evidence of association was found between disease-modifying therapy and seizure risk—this informs seizure management in multiple sclerosis patients.
Perspectives of social workers and supervisors about the supervision of protective services
Authors: Yu Mei-Kuei , Liao Min-Yu 
Published: February 2023

Summary Although numerous studies have quantitatively examined the different aspects of supervision, such as satisfaction in clinical and student supervision, empirical evidence on current practices in the supervision of protective services is limited. The present study explored barriers that protective social workers and their supervisors (line managers) face with respect to supervisory support. Moreover, the perceived challenges related to supervision were identified. The participants were recruited from public and private protective service organizations across Taiwan. In-depth interviews were conducted by the authors on 10 social workers and 10 supervisors. Findings Through the analysis of the transcripts, four themes were identified: emotional responses, knowledge components, modeling of values and creation of a culture of equality, and tensions related to supervisory accountability. Exploring protective social workers and supervisors’ perspectives on supervision is essential for understanding the complex needs of these employees. Applications The present findings fill the research gap on the supervision of protective services and constitute a foundation for future studies on this subject. The findings contribute to the literature on the supervision of protective services, which is beginning to address issues concerning supervisees’ emotional responses, supervisory knowledge, supervisor–supervisee relationships, and supervisory accountability. Potential limitations of the study were also discussed.
Long-Term Survival and Quality of Life After Fenestrated Endovascular Repair for Complex Abdominal Aortic Aneurysms
Authors: Schreuder Wietske M. A. , Dijkstra Martijn L. , von Meijenfeldt Gerdine C. I. , Tielliu Ignace F. J. , Zeebregts Clark J. , Saleem Ben R. , van der Laan Maarten J. 
Published: February 2023

Objectives Fenestrated endovascular repair (FEVAR) has become a widely used treatment option for complex abdominal aortic aneurysms (AAA) but long-term survival and quality of life (QoL) outcomes are scarce. This single center cohort study aims to evaluate both long-term survival and QoL after FEVAR. Methods All juxtarenal and suprarenal AAA patients treated with FEVAR in a single-center between 2002 and 2016 were included. QoL scores, measured by the RAND 36-Item Short Form Survey (SF-36), were compared with baseline data of the SF-36 provided by RAND. Results A total of 172 patients were included at a median follow-up of 5.9 years (IQR 3.0-8.8). Follow-up at 5 and 10 years post-FEVAR yielded survival rates of 59.9% and 18%, respectively. Younger patient age at surgery had a positive influence on 10-year survival and most patients died due to cardiovascular pathology. Emotional well-being was better in the research group as compared to baseline RAND SF-36 1.0 data (79.2 ± 12.4 vs 70.4 ± 22.0; P < 0.001). Physical functioning (50 (IQR 30–85) vs 70.6 ± 27.4; P = 0.007) and health change (51.6 ± 17.0 vs 59.1 ± 23.1; P = 0.020) were worse in the research group as compared to reference values. Conclusions Long-term survival was 60% at 5-years follow-up, which is lower than reported in recent literature. An adjusted positive influence of younger age at surgery was found on long-term survival. This could have consequences for future treatment indication in complex AAA surgery but further large-scale validation is necessary.
A novel histological occlusion classification for coiled aneurysms based on multiphoton microscopy
Authors: Zoltan Szatmary , Jonathan Cortese , Jeremy Mounier , Marie-Laure Perrin , Kevin Janot , Claude Couquet , Le Flahec Aurélien , Claire Leger-Bretou , Charbel Mounayer , Aymeric Rouchaud , Bardet Sylvia M 
Published: February 2023

Objective Intracranial aneurysm (IA) coiling remains the most commonly used endovascular approach for ruptured and unruptured IA, and recanalization is a common drawback that impairs treatment success. Angiographic occlusion and aneurysm healing are not synonymous, and histological evaluation of embolized aneurysms remains a challenge. We propose here an experimental study of coil embolization in animal models by multiphoton microscopy (MPM) in comparison with conventional histological staining. The purpose of his work is to analyze coil healing process using histological sections of aneurysms. Methods Based on a rabbit elastase model, 27 aneurysms were fixed, embedded in resin, and cut in thin histological sections 1 month after coils implantation and after angiographic control. Hematoxylin and eosin (H&S) staining were realized. Non-stained adjacent slices were imaged for multiphoton excited autofluorescence (AF) and second-harmonic generation (SHG) to construct three-dimensional (3D) projections of sequentially and axially acquired images. Results The contrast provided by the combination of these two imaging modalities can be used to distinguish five levels of aneurysm healing, based on a combination of thrombus evolution and increased extracellular matrix (ECM) deposit. Conclusion RDPC:\Users\SHAHUL\RDP6|We have established a novel histological scale from a rabbit elastase aneurysm model after coiling with a classification of five different stages thanks to nonlinear microscopy. This classification is an actualized tool in order to obtain a more precise evaluation of occlusion device efficacy in the scope of new innovative microscopy for research.
Patient attitudes, experiences, and satisfaction with healthcare and office visit utilization among Medicare beneficiaries with type 2 diabetes
Authors: He Qing , Hawkins Georgianne Tiu , Park Chanhyun , Han Sola , LaManna Jacqueline B. , Ng Boon Peng 
Published: February 2023

Objectives To examine patient attitudes, experiences, and satisfaction with healthcare associated with office visit utilization among Medicare beneficiaries with type 2 diabetes. Methods We analyzed the 2019 Medicare Current Beneficiary Survey Public Use File of beneficiaries aged ≥65 years with type 2 diabetes ( n = 1092). The ordinal dependent variable was defined as 0, 1 to 5, and ≥6 office visits. An ordinal partial proportional odds model was conducted to examine associations of beneficiaries’ attitudes, experiences, and satisfaction with healthcare and office visit utilization. Results Among the beneficiaries, approximately 17.7%, 22.8%, and 59.5% reported having 0, 1 to 5, and ≥6 office visits, respectively. Being male (OR = 0.67, p = 0.004), Hispanic (OR = 0.53, p = 0.006), divorced/separated (OR = 0.62, p = 0.038) and living in a non-metro area (OR = 0.53, p < 0.001) were associated with a lower likelihood of attending more office visits. Trying to keep sickness to themselves (OR = 0.66, p = 0.002) and dissatisfaction with the ease and convenience of getting to providers from home (OR = 0.45, p = 0.010) were associated with a lower likelihood of having more office visits. Discussion The proportion of beneficiaries foregoing office visits is concerning. Attitudes concerning healthcare and transportation challenges can be barriers to office visits. Efforts to ensure timely and appropriate access to care should be prioritized for Medicare beneficiaries with diabetes.
Reliability and validity of the K-force grip dynamometer in healthy subjects: do we need to assess it three times?
Authors: Magni Nico , Olds Margie , McLaine Sally 
Published: February 2023

Introduction Digital dynamometers to assess grip strength are becoming more common in research and clinical settings. The aim of the study was to assess validity and reliability of the K-force dynamometer compared to the Jamar dynamometer. We also aimed to assess differences over the course of three measurements. Methods Twenty-seven healthy participants were included. Three trials with the K-force and Jamar dynamometers were completed. Testing order was randomised. Intraclass correlation coefficients (ICCs) with absolute agreement assessed reliability and validity. Standard error of the measurement (SEM) and minimal detectable change (MDC95) were calculated. Concurrent validity was assessed using Pearson’s correlations and ICCs. Differences between the three repetitions were assessed using one-way repeated measures ANOVAs. Results Both the K-force and the Jamar presented excellent intra-rater reliability with ICCs ranging from 0.96 to 0.97. The SEM ranged from 1.7 to 2 kg and the MDC from 4.7 to 5.7 kg for both dynamometers. The concurrent validity of the K-force was high ( r ≥ 0.89). However, the K-force underestimated the grip strength by 4.5–8.5 kg. There was no change in grip strength with either dynamometer over the course of three trials. Conclusions: The K-force is reliable, but it underestimates grip strength by 4.5–8.5 kg compared to the Jamar dynamometer. K-force can be used to monitor progress over time but cannot be used to compare results against normative data. The use of a single measurement when assessing grip strength is sufficient when assessing healthy subjects.