bluuebunny/crossref_metadata_2025_split huggingface dataset:
Letter: serum hepatitis B virus DNA and risk of hepatocellular carcinoma in patients with chronic hepatitis B
Authors: Huang Rui , Liu Jiacheng , Wang Jian , Yan Xiaomin , Wu Chao 
Published: September 2023

LINKED CONTENTThis article is linked to Kim et al and Kin & Lim papers. To view these articles, visit https://doi.org/10.1111/apt.15725 and https://doi.org/10.1111/apt.16278
Letter: the improvement of sarcopenia after TIPSS might result from the survivor bias—authors' reply
Authors: Artru Florent , Labreuche Julien , Duhamel Alain , Louvet Alexandre 
Published: September 2023

LINKED CONTENTThis article is linked to Artru et al and Chen et al papers. To view these articles, visit https://doi.org/10.1111/apt.16080 and https://doi.org/10.1111/apt.16255
Editorial: is enteral nutrition back in acute severe ulcerative colitis? Authors' reply
Authors: Sahu Pabitra , Kedia Saurabh , Kumar Vuyyuru Sudheer , Travis Simon , Ahuja Vineet 
Published: September 2023

LINKED CONTENTThis article is linked to Sahu et al and Laharie papers. To view these articles, visit https://doi.org/10.1111/apt.16249 and https://doi.org/10.1111/apt.16260
The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis
Authors: Zhang Chengyuan , Qiu Yongjia , Yuan Feng 
Published: September 2023

AbstractNucleus pulposus (NP) cell apoptosis is regarded as a critical risk factor for intervertebral disc degeneration (IVDD). Melatonin exerts a protective role on NP cells. The study concentrates on the role and mechanism of lncRNA MEG3 in melatonin‐mediated effects on NP cells. An in vitro IVDD model was constructed using IL‐1β on human NP cells. qRT‐PCR investigated MEG3, miR‐15a‐5p and PGC‐1α mRNA levels in tissues and NP cells. IL‐1β‐treated NP cells subsequent to transfection, followed by melatonin treatment. NP cell proliferation, viability, apoptosis and inflammatory reactions were assayed. Western blot checked the profiles of PGC‐1α, SIRT1 and NF‐κB p65. Student's t‐test or one‐way analysis of variance (ANOVA) followed by Tukey's test was used for statistical tests. As indicated by the data, melatonin weakened NP cell inflammation and apoptosis and enhanced MEG3 expression. MEG3 expression was attenuated in IVDD tissues. MEG3 knockdown impaired the function of melatonin, which was, however, strengthened by miR‐15a‐5p knockdown. MEG3 targeted miR‐15a‐5p, which targeted PGC‐1α and repressed the PGC‐1α/SIRT1 pathway. Collectively, this study has disclosed that the MEG3‐miR‐15a‐5p‐PGC‐1α/SIRT1 pathway modulated by melatonin can hamper NP cell apoptosis and inflammation elicited by IL‐1β.
Long‐term follow‐up of haploidentical haematopoietic stem cell transplantation in paediatric patients with high‐risk acute myeloid leukaemia: Report from a single centre
Authors: Bai Lu , Zhang Zhi‐Xiao , Hu Guan‐Hua , Cheng Yi‐Fei , Suo Pan , Wang Yu , Yan Chen‐Hua , Sun Yu‐Qian , Chen Yu‐Hong , Chen Huan , Liu Kai‐Yan , Xu Lan‐Ping , Huang Xiao‐Jun 
Published: September 2023

SummaryData from 200 children with high‐risk acute myeloid leukaemia who underwent their first haploidentical haematopoietic stem cell transplantation (haplo‐HSCT) between 2015 and 2021 at our institution were analysed. The 4‐year overall survival (OS), event‐free survival (EFS) and cumulative incidence of relapse (CIR) were 71.9%, 62.3% and 32.4% respectively. The 100‐day cumulative incidences of grade II–IV and III–IV acute graft‐versus‐host disease (aGVHD) were 41.1% and 9.5% respectively. The 4‐year cumulative incidence of chronic GVHD (cGVHD) was 56.1%, and that of moderate‐to‐severe cGVHD was 27.3%. Minimal residual disease (MRD)‐positive (MRD+) status pre‐HSCT was significantly associated with lower survival and a higher risk of relapse. The 4‐year OS, EFS and CIR differed significantly between patients with MRD+ pre‐HSCT (n = 97; 63.4%, 51.4% and 41.0% respectively) and those with MRD‐negative (MRD‐) pre‐HSCT (n = 103; 80.5%, 73.3% and 23.8% respectively). Multivariate analysis also revealed that acute megakaryoblastic leukaemia without Down syndrome (non‐DS‐AMKL) was associated with extremely poor outcomes (hazard ratios and 95% CIs for OS, EFS and CIR: 3.110 (1.430–6.763), 3.145 (1.628–6.074) and 3.250 (1.529–6.910) respectively; p‐values were 0.004, 0.001 and 0.002 respectively). Thus, haplo‐HSCT can be a therapy option for these patients, and MRD status pre‐HSCT significantly affects the outcomes. As patients with non‐DS‐AMKL have extremely poor outcomes, even with haplo‐HSCT, a combination of novel therapies is urgently needed.
The small‐molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti‐inflammatory in mouse precision‐cut lung slices
Authors: Studley William R. , Lamanna Emma , Martin Katherine A. , Nold‐Petry Claudia A. , Royce Simon G. , Woodman Owen L. , Ritchie Rebecca H. , Qin Cheng Xue , Bourke Jane E. 
Published: September 2023

AbstractBackground and PurposePulmonary arterial hypertension (PAH), a rare fatal disorder characterised by inflammation, vascular remodelling and vasoconstriction. Current vasodilator therapies reduce pulmonary arterial pressure but not mortality. The G‐protein coupled formyl peptide receptors (FPRs) mediates vasodilatation and resolution of inflammation, actions possibly beneficial in PAH. We investigated dilator and anti‐inflammatory effects of the FPR biased agonist compound 17b in pulmonary vasculature using mouse precision‐cut lung slices (PCLS).Experimental ApproachPCLS from 8‐week‐old male and female C57BL/6 mice, intrapulmonary arteries were pre‐contracted with 5‐HT for concentration–response curves to compound 17b and 43, and standard‐of‐care drugs, sildenafil, iloprost and riociguat. Compound 17b‐mediated relaxation was assessed with FPR antagonists or inhibitors and in PCLS treated with TNF‐α or LPS. Cytokine release from TNF‐α‐ or LPS‐treated PCLS ± compound 17b was measured.Key ResultsCompound 17b elicited concentration‐dependent vasodilation, with potencies of iloprost > compound 17b = riociguat > compound 43 = sildenafil. Compound 17b was inhibited by the FPR1 antagonist cyclosporin H but not by soluble guanylate cyclase, nitric oxide synthase or cyclooxygenase inhibitors. Under inflammatory conditions, the efficacy and potency of compound 17b were maintained, while iloprost and sildenafil were less effective. Additionally, compound 17b inhibited secretion of PAH‐relevant cytokines via FPR2.Conclusions and ImplicationsVasodilation to compound 17b but not standard‐of‐care vasodilators, is maintained under inflammatory conditions, with additional inhibition of PAH‐relevant cytokine release. This provides the first evidence that targeting FPR, with biased agonist, simultaneously targets vascular function and inflammation, supporting the development of FPR‐based pharmacotherapy to treat PAH.LINKED ARTICLESThis article is part of a themed issue Therapeutic Targeting of G Protein‐Coupled Receptors: hot topics from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 2021 Virtual Annual Scientific Meeting. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.14/issuetoc
Tone management: An environmental scan of current management practices across Canada
Authors: Tran My‐An , Thipse Madhura , Tsampalieros Anne , Webster Richard , McCormick Anna , Alazem Hana , Venkateswaran Sunita , Cheung Kevin , Smit Kevin , Tu Albert 
Published: September 2023

AbstractBackgroundCurrently, there are no standardized approaches to care or evaluation for tone dysfunction in Canada. The study authors hypothesize that there is significant practice variation across the country. This environmental scan is aimed to describe the current practice for management of paediatric patients with hypertonia across Canada.MethodsA web‐based survey was developed by the authors with a multi‐disciplinary approach and sent to representative paediatric rehabilitation sites in each province in Canada. Disciplines at the rehabilitation sites surveyed included all or some of the following disciplines: physiatry, neurology, neurosurgery, plastic surgery, orthopaedic surgery, physiotherapy and occupational therapy. All statistical analyses were performed using the R statistical software version 4.0. Fifteen rehabilitation sites were contacted, and 12 sites were used for the final analysis.ResultsCerebral palsy was found to be the most common diagnosis for tone dysfunction, with 58% of sites diagnosing greater than 20 new patients per year. In 67% of sites, patients were seen within a formal multidisciplinary clinic to manage hypertonia. All 12 sites utilized oral baclofen and gabapentin, and 92% of sites utilized trihexyphenidyl. Botulinum toxin injections were offered at 50% of sites. Upper and lower extremity surgical procedures were offered in 83% of the sites.ConclusionThe information gained from this study provides some insight into the current practice across Canada for children with hypertonia. This study may assist in the development of a national, standardized strategy to tone management, potentially facilitating more equitable access to care for patients.
Reconceptualising coproduction as activism together
Authors: McMellon Christina , McCusker Pearse , Roesch‐Marsh Autumn , Hall Lauren , Bartlett Thomas , McDermott Rachel 
Published: September 2023

AbstractThe COVID‐19 pandemic disrupted life across the world in multiple ways and those already minoritised and disenfranchised, like care‐experienced young people, bore the brunt of losses and mental health difficulties. This article reports on the findings of ‘Feeling Well, Feeling Cared For’ an innovative knowledge exchange project on care experience and mental health in Scotland that was seriously disrupted by the pandemic. The article explores how these disruptions created new opportunities for deepening and slowing down coproductive practices, allowing relationships between collaborators to become stronger. Three finding areas are presented and discussed through the lenses of coproduction and quiet activism. These include lessons developed through the process of carrying out this project during a pandemic, the findings from our discussions with young people about mental health, and our reflections on the meanings of activism in the context of a coproductive knowledge exchange process. The discussion highlights how learning from this project might benefit coproductive practices in the future, especially as global interest in coproduction continues to grow across a range of disciplines.
Being me in times of change: Young children's reflections on their lives during the COVID‐19 pandemic
Authors: Carpenter Euna , Siegel Abigail , Urquiola Sofia , Liu Judy , Kushnir Tamar 
Published: September 2023

AbstractResearch from the perspective of parents, educators and mental health professionals has documented the negative impacts of pandemic isolation on children, but few studies have sought children's own perspectives on this difficult year. The current study aims to provide a first‐person perspective on children's psychological health by asking children directly about their experiences of isolating at home. We interviewed 28 seven‐ to eleven‐year‐olds in early days of lockdowns with follow‐ups 6 months later. Children answered questions about family, school, friendships and feelings about the changes in their lives during lockdown. Children's reflections showed resilience, adaptability, positive appraisals and an ability to maintain meaningful social connections. This data underscores the value of including children's narratives to better understand the pandemic's lasting effects on their lives.
A quantitative and T‐pattern analysis of anxiety‐like behavior in male GAERS, NEC, and Wistar rats bred under the same conditions, against a commercially available Wistar control group in the hole board and elevated plus maze tests
Authors: Casarrubea Maurizio , Radic Manuela , Morais Tatiana P , Mifsud Erika , Cuboni Eleonora , Aiello Stefania , Crescimanno Giuseppe , Crunelli Vincenzo , Di Giovanni Giuseppe 
Published: September 2023

AbstractAimThe Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are an inbred polygenic model of childhood absence epilepsy (CAE), which, as their non‐epileptic control (NEC) rats, are derived from Wistar rats. While the validity of GAERS in reproducing absence seizures is well established, its use as a model for CAE psychiatric comorbidities has been subject to conflicting findings. Differences in colonies, experimental procedures, and the use of diverse controls from different breeders may account for these disparities. Therefore, in this study, we compared GAERS, NEC, and Wistar bred in the same animal facility with commercially available Wistar (Cm Wistar) as a third control.MethodsWe performed hole board (HB) and elevated plus maze (EPM) tests that were analyzed with standard quantitative and T‐pattern analysis in male, age‐matched Cm Wistar and GAERS, NEC, and Wistar, bred under the same conditions, to rule out the influence of different housing factors and provide extra information on the structure of anxiety‐like behavior of GAERS rats.ResultsQuantitative analysis showed that GAERS and NEC had similar low anxiety‐like behavior when compared to Cm Wistar but not to Wistar rats, although a higher hole‐focused exploration was revealed in NEC. T‐pattern analysis showed that GAERS, NEC, and Wistar had a similar anxiety status, whereas GAERS and NEC exhibited major differences with Cm Wistar but not Wistar rats. EPM results indicated that GAERS and NEC also have similar low anxiety compared to Cm Wistar and/or Wistar rats. Nevertheless, the analysis of the T‐pattern containing open‐arm entry showed GAERS and Wistar to be less anxious than NEC and Cm Wistar rats.ConclusionTo summarize, comorbid anxiety may not be present in male GAERS rats. This study also highlighted the importance of including a control Wistar group bred under the same conditions when evaluating their behavior, as using Wistar rats from commercial breeders can lead to misleading results.
Pure laparoscopic donor right hepatectomy in patients over 50 years old: Why age should not be a barrier
Authors: Han Eui Soo , Hong Suk Kyun , Hong Kwangpyo , Hong Su young , Lee Jeong‐Moo , Choi YoungRok , Yi Nam‐Joon , Lee Kwang‐Woong , Suh Kyung‐Suk 
Published: September 2023

AbstractIntroductionGiven the global aging population, the average age of liver donors is increasing. This study aimed to evaluate the surgical outcomes of grafts from pure laparoscopic donor right hepatectomy (PLDRH) in liver donors aged > 50 years.MethodsThe medical records of liver donors were retrospectively reviewed. The donors underwent conventional donor right hepatectomy (CDRH) from January 2011 to May 2019 or PLDRH from March 2016 to May 2019. We divided the donors into three groups: PLDRH donors aged ≥50 (n = 26; Group 1) and aged < 50 (n = 257; Group 2), and CDRH donors aged ≥50 years (n = 66; Group 3).ResultsOperation time (p < .01) and hospital stay (p < .01) were significantly lower in Group 1 than in Group 3. Other postoperative outcomes of donors including graft anatomical variation, graft weight, graft‐to‐recipient weight ratio, and hepatic steatosis were similar among the three groups. Although no postoperative complications occurred in Groups 1 and 3, they were detected in 17 cases (6.6%) in Group 2. No postoperative complications were detected among the recipients.ConclusionsPLDRH was feasible and safe in donors aged over 50 years, with outcomes similar to those for donors aged <50 years. PLDRH should not be avoided solely based on the donor's age ≥50 years.
A proposed objective scale for extracorporeal membrane oxygenation circuit thrombosis
Authors: Konsek Haley , Mealer Corey , Skidmore Savannah , Collins Monika , Tchantchaleishvili Vakhtang , Rajab Taufiek Konrad 
Published: September 2023

AbstractPatients undergoing extracorporeal membrane oxygenation (ECMO) are susceptible to thrombosis, which is a major cause of death and morbidity. However, there is no objective ECMO thrombosis grading scale to standardize evaluation, guide treatment, and facilitate further research. In this letter, we propose an objective grading scale for ECMO circuit thrombosis based on physical characteristics and location within the circuit. This ECMO thrombosis scale will allow for protocolized escalation of ECMO thrombosis treatment, ranging from watchful observation, intensified anticoagulation, and circuit exchange.
Development of a localization‐based algorithm for the prediction of leg ulcer etiology
Authors: Deinsberger Julia , Moschitz Irina , Marquart Elias , Manz‐Varga Alexander Konstantin , Gschwandtner Michael E. , Brugger Jonas , Rinner Christoph , Böhler Kornelia , Tschandl Philipp , Weber Benedikt 
Published: September 2023

SummaryBackgroundDiagnostic work‐up of leg ulcers is time‐ and cost‐intensive. This study aimed at evaluating ulcer location as a diagnostic criterium and providing a diagnostic algorithm to facilitate differential diagnosis.Patients and MethodsThe study consisted of 277 patients with lower leg ulcers. The following five groups were defined: Venous leg ulcer, arterial ulcers, mixed ulcer, arteriolosclerosis, and vasculitis. Using computational surface rendering, predilection sites of different ulcer types were evaluated. The results were integrated in a multinomial logistic regression model to calculate the likelihood of a specific diagnosis depending on location, age, bilateral involvement, and ulcer count. Additionally, neural network image analysis was performed.ResultsThe majority of venous ulcers extended to the medial malleolar region. Arterial ulcers were most frequently located on the dorsal aspect of the forefoot. Arteriolosclerotic ulcers were distinctly localized at the middle third of the lower leg. Vasculitic ulcers appeared to be randomly distributed and were markedly smaller, multilocular and bilateral. The multinomial logistic regression model showed an overall satisfactory performance with an estimated accuracy of 0.68 on unseen data.ConclusionsThe presented algorithm based on ulcer location may serve as a basic tool to narrow down potential diagnoses and guide further diagnostic work‐up.
Common Challenges for All? A Critical Engagement with the Emerging Vision for Post‐pandemic Development Studies
Authors: Wiegratz Jörg , Behuria Pritish , Laskaridis Christina , Pheko Lebohang Liepollo , Radley Ben , Stevano Sara 
Published: September 2023

ABSTRACTThe COVID‐19 pandemic motivated calls for the field of development studies to be recast. This article analyses two prominent, future‐gazing ‘pandemic papers’ to illustrate salient features of the ascendant trend towards a new ‘global development’ paradigm. By unpacking and interpreting major lines of reasoning put forward by two agenda‐setting articles, this contribution appraises how these texts make the case for the future of development studies. Through this analysis, the article questions the core arguments that seek to shift the contours of the discipline, and thus the study of development generally. In making their call to adopt a universalist or global development framework that includes a focus on Europe and North America, the authors of the ‘pandemic papers’ overlook the Southern origins of and justifications for the North‒South framework they seek to overturn. The present article acknowledges the importance of and supports returning to and advancing — rather than jettisoning — the intellectual lineage anchored in non‐Truman understandings of development, including as a popular project of Southern emancipation from colonial, imperial and structural subordination. Rather than de‐centring the global North‒South framework, it suggests that the analytically more useful way forward is for development studies to (re)centre the global South and use global South theories and lenses to better understand the world economy and the majority world.
Echocardiography algorithms to assess high left atrial pressure and grade diastolic function in preterm infants
Authors: de Waal Koert , Phad Nilkant , Crendal Edward 
Published: September 2023

AbstractBackgroundRelaxation, restoring forces, myocardial stiffness and atrial function determine left ventricular (LV) diastolic function. This study aims to provide a comprehensive assessment of diastolic function in preterm infants using conventional echocardiography and speckle tracking imaging and determine the diagnostic accuracy of various algorithms to detect high left atrial pressure (LAP).MethodsPreterm infants received an echocardiogram 1 week after birth and diastolic reference values were derived from the outer percentiles of stable preterm infants. Impaired relaxation, LV stiffness and high LAP were defined by using algorithms where at least half of the parameters were outside the normal range. Diastolic function was graded using the 2016 American Society of Echocardiography algorithm and expanded with the EA ratio and left atrial strain. The diagnostic accuracy of various algorithms to detect high LAP was determined with sensitivity analysis.ResultsWe studied 146 infants (59 stable) with a mean of 27(1) weeks gestation. Impaired relaxation, LV stiffness and high LAP were found in 8%, 7%, and 14% of infants. The patent ductus arteriosus was a contributing factor to high LAP and LV stiffness, not impaired relaxation. Diagnostic accuracy improved from 90% to 96% and sensitivity from 40% to 90% by adding left atrial strain to the 2016 algorithm.ConclusionVarious grades of diastolic dysfunction could be appreciated in preterm infants using a multi‐parameter approach. Adding left atrial strain improved sensitivity to detect infants with high LAP.