bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal regeneration risk assessment in the treatment of intrabony defects
Authors: Levine Robert A. , Saleh Muhammad H. A. , Dias Debora R. , Ganeles Jeffrey , Araújo Maurício G. , Renouard Franck , Pinsky Harold M. , Miller Preston D. , Wang Hom‐Lay 
Published: June 2023

AbstractBackgroundRegenerative approaches performed in periodontics seems to be efficient in treating intrabony defects. There are, however, many factors that may affect the predictability of the regenerative procedures. The present article aimed to propose a new risk assessment tool for treating periodontal intrabony defects by regenerative therapy.MethodsDifferent variables that could affect the success of a regenerative procedure were considered based on their impact on (i) the wound healing potential, promoting wound stability, cells, and angiogenesis, or (ii) the ability to clean the root surface and maintain an optimal plaque control or (iii) aesthetics (risk for gingival recession).ResultsThe risk assessment variables were divided into a patient, tooth, defect, and operator level. Patient‐related factors included medical conditions such as diabetes, smoking habit, plaque control, compliance with supportive care, and expectations. Tooth‐related factors included prognosis, traumatic occlusal forces or mobility, endodontic status, root surface topography, soft tissue anatomy, and gingival phenotype. Defect‐associated factors included local anatomy (number of residual bone walls, width, and depth), furcation involvement, cleansability, and number of sides of the root involved. Operator‐related factors should not be neglected and included the clinician's level of experience, the presence of environmental stress factors, and the use of checklists in the daily routine.ConclusionsUsing a risk assessment comprised of patient‐, tooth‐, defect‐ and operator‐level factors can aid the clinician in identifying challenging characteristics and in the treatment decision process.
Synthesis, Antioxidant and Antiproliferative Evaluation, Molecular Docking and DFT Studies of Some Novel Coumarin and Fused Coumarin Derivatives
Authors: Gouda Mustafa A. S. , Salem Mounir A. I. , Marzouk Magda I. , Mahmoud Naglaa F. H. , Ismail Mahmoud F. 
Published: June 2023

AbstractN′‐[(4‐Chloro‐2‐oxo‐2H‐chromen‐3‐yl)methylene]‐2‐cyanoacetohydrazide (3) was synthesized in excellent yield from the condensation of 4‐Chloro‐2‐oxo‐2H‐chromene‐3‐carbaldehyde with cyanoacetohydrazide. Compound 3 was utilized as a building block to synthesize novel coumarin and heterocycle‐fused coumarin derivatives. The chemical structures of all the new coumarin compounds were identified by spectral analyses. Some of the new coumarins compounds were screened in human cancer cell lines (HEPG‐2, MCF‐7, HCT‐116 and PC‐3) to learn about their cytotoxic effects in addition to the study of their DNA damage and antioxidant activity. Three of these compounds exhibited remarkable antioxidant and anti‐proliferative activities. Moreover, they have the capability to protect DNA from damage induced by bleomycin. Molecular docking, DFT and molecular electrostatic potential studies were performed on the compounds in vitro.
Density Functional Theory Calculations for Multiple Conformers Explaining the Regio‐ and Stereoselectivity of Ti‐Catalyzed Hydroaminoalkylation Reactions
Authors: Thoben Niklas , Kaper Tobias , de Graaff Simon , Gerhards Luca , Schmidtmann Marc , Klüner Thorsten , Beckhaus Rüdiger , Doye Sven 
Published: June 2023

AbstractHybrid Density Functional Theory (DFT) calculations for multiple conformers of the insertion reactions of a methylenecyclopropane into the Ti−C bond of two differently α‐substituted titanaaziridines explain the experimentally observed differences in regioselectivity between catalytic hydroaminoalkylation reactions of methylenecyclopropanes with α‐phenyl‐substituted secondary amines and corresponding stoichiometric reactions of a methylenecyclopropane with titanaaziridines, which can only be achieved with α‐unsubstituted titanaaziridines. In addition, the lack of reactivity of α‐phenyl‐substituted titanaaziridines as well as the diastereoselectivity of the catalytic and stoichiometric reactions can be understood.
Sustainable Polyvinyl Chloride‐Derived Soft Carbon Anodes for Potassium‐Ion Storage: Electrochemical Behaviors and Mechanism
Authors: He Xing , Zhong Lei , Qiu Xueqing , Wen Fuwang , Sun Shirong , Zu Xihong , Zhang Wenli 
Published: June 2023

AbstractSoft carbon is a promising anode material for potassium‐ion batteries due to its favorable properties such as low cost, high conductivity, stable capacity, and low potential platform. Polyvinyl chloride, as a white pollutant, is a soft carbon precursor that can be carbonized at varying temperatures to produce soft carbons with controllable defect and crystal structures. This work investigates the effect of carbonization temperature on the crystalline structures of the obtained soft carbons. In situ Raman spectroscopy was used to elucidate the adsorption‐intercalation charge storage mechanism of potassium ions in soft carbons. Soft carbons prepared at the temperature of 800 °C have a defect‐rich, short‐range ordered structure, which provides optimal intercalation and adsorption sites for potassium ions, resulting in a satisfactory capacity of 302 mAh g−1. This work presents new possibilities for designing soft carbon materials from recycling plastics for potassium‐ion batteries.
Narrow‐band imaging with magnification for the diagnosis of colorectal adenoma in a patient with Cronkhite‐Canada syndrome
Authors: Fukase Hitoshi , Honda Munenori , Miyamoto Hideaki , Nakashima Masatoshi , Gushima Ryosuke , Naoe Hideaki , Yamada Rin , Komohara Yoshihiro , Tanaka Yasuhito 
Published: June 2023

AbstractCronkhite‐Canada syndrome (CCS) is a rare disease characterized by gastrointestinal polyposis, skin pigmentation, alopecia, and abnormal nailfolds. Although colorectal cancer has been reported in patients with CCS, reports are limited regarding the effectiveness of the usage of image‐enhanced endoscopy in CCS lesions. Here, we report a case of CCS in which narrow‐band imaging (NBI) magnifying endoscopy was applied to detect an adenomatous component in multiple hamartomatous polyps. A 79‐year‐old female complained of taste disorder, anorexia, and weight loss over several months. Endoscopic examination revealed multiple reddened polyps in the stomach and colon, leading to a diagnosis of CCS. Narrow‐band imaging magnification showed sparse and dilated round pits on the CCS polyps. Furthermore, 12 out of the numerous colorectal CCS polyps had a coexisting light reddish elevated component with a regular distribution of microvessels and a regular reticular pattern. This pattern satisfied the criteria for Type 2A of the Japan Narrow‐band‐imaging Expert Team classification, indicating adenoma. After resection, these twelve polyps were subject to pathological analysis, which confirmed they were all hamartomatous polyps with low‐grade adenoma on the superficial layer. Immunohistochemical analysis revealed a significant increase in the Ki‐67 index and p53 staining only in the adenomatous lesions. We conclude that narrow‐band imaging magnifying endoscopy would be useful in differentiating adenoma from CCS‐related polyps, which thereby facilitates early detection and treatment of precancerous lesions.
Barriers and enablers to participation in the National Cervical Screening Program experienced by young women and people with a cervix aged between 25 and 35
Authors: Temminghoff Lauren , Russell Claire , Andersson Tove , Broun Kate , McGrath Nikki , Wyatt Kerryann 
Published: June 2023

AbstractIssue AddressedCervical screening rates for young women aged between 25 and 35 are lower than older Australian women, however, little research has been conducted to understand why. This study aimed to identify and explore the barriers and enablers faced by young Victorians with a cervix to regular cervical screening.MethodsThis study used a mixed method exploratory design consisting of qualitative focus groups and a quantitative online survey. Four focus groups were conducted with 24 Victorians with a cervix aged between 25 and 35. Barriers, enablers and knowledge of cervical screening were explored. Focus groups were recorded and transcribed for thematic analysis of common themes. A supporting online survey was completed by 98 respondents. Summary statistics were analysed for differences in age.ResultsFocus groups and the online survey revealed four main factors that influence young people's cervical screening behaviour. These include past negative screening experiences, practitioner factors, priority placed on cervical screening, and cervical screening knowledge. These factors differ to the opinions of people older than 35, with young people focusing more on the psychological elements of cervical screening compared with practical factors.ConclusionsThis research provides a unique insight into cervical screening barriers faced by women and people with a cervix aged between 25 and 35 as well as what factors motivate them to screen.So What?These findings should be utilised to inform the design of public health campaign messaging targeting this age demographic. Findings can also assist practitioners to improve how they communicate with young people in a clinical setting.
A Randomized, Controlled Study to Assess Changes in Biomarkers of Exposures Among Adults Who Smoke That Switch to Oral Nicotine Pouch Products Relative to Continuing Smoking or Stopping All Tobacco Use
Authors: Rensch Jesse , Edmiston Jeffery , Wang Jingzhu , Jin Xiaohong , Sarkar Mohamadi 
Published: June 2023

AbstractThe purpose of this open‐label, randomized, controlled, in‐clinic, 5‐parallel‐group study was to assess biomarkers of exposure (BoE) to select harmful and potentially harmful constituents in adults who smoke (N = 144) switching to oral tobacco products (on!® mint nicotine pouches; test products) compared to continuing smoking cigarettes (CS) and completely quitting all tobacco products (NT). Changes in 20 BoE to select harmful and potentially harmful constituents, including 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL), were evaluated. Adult smokers smoked their usual brand of cigarettes for 2 days (baseline assessments) and then were randomly assigned to ad libitum use of 2, 4, or 8 mg test products, CS, or NT for 7 days. Analysis of covariance was used to assess the Day 7 BoE levels between each group using test products, CS, and NT. The creatinine‐adjusted total urinary NNAL and other 18 of 19 BoE levels (except nicotine equivalents [NEs]) were significantly lower (P < .05) on Day 7, among all test product groups compared to CS. Geometric least‐square means were reduced for all biomarkers of exposure, except NEs, in test product groups by approximately 42%–96% compared to the CS group, and reductions were comparable to the NT group. The geometric least‐square means for urinary NE between the test product and the CS groups, although not significantly different, the Day 7 mean change relative to the CS group were 49.9%, 65.8%, and 101% for the 2, 4, and 8 mg test product groups, respectively. The substantial reduction in harmful and potentially harmful constituent exposure suggests complete switching from cigarettes to test products may present a harm reduction opportunity for adults who smoke.
Multilevel analysis of matching behavior: A comparison of maximum likelihood and Bayesian estimation
Authors: Ilagan Michael John , Caron Pier‐Olivier , Miočević Milica 
Published: June 2023

AbstractWhile trying to infer laws of behavior, accounting for both within‐subjects and between‐subjects variance is often overlooked. It has been advocated recently to use multilevel modeling to analyze matching behavior. Using multilevel modeling within behavior analysis has its own challenges though. Adequate sample sizes are required (at both levels) for unbiased parameter estimates. The purpose of the current study is to compare parameter recovery and hypothesis rejection rates of maximum likelihood (ML) estimation and Bayesian estimation (BE) of multilevel models for matching behavior studies. Four factors were investigated through simulations: number of subjects, number of measurements by subject, sensitivity (slope), and variance of the random effect. Results showed that both ML estimation and BE with flat priors yielded acceptable statistical properties for intercept and slope fixed effects. The ML estimation procedure generally had less bias, lower RMSE, more power, and false‐positive rates closer to the nominal rate. Thus, we recommend ML estimation over BE with uninformative priors, considering our results. The BE procedure requires more informative priors to be used in multilevel modeling of matching behavior, which will require further studies.
Construction of a prognostic model based on genes associated with mitochondrial energy metabolic pathway in colon adenocarcinoma and its clinical significance
Authors: Zhang Xiangcheng , Liang Ce , Zhou Bingchuan , Pang Liming 
Published: June 2023

AbstractMitochondria are the main sites of oxidative metabolism and energy release of sugars, fats and amino acids in the body. According to studies, malignant tumor occurrence and development have been linked to abnormal mitochondrial energy metabolism (MEM). However, the feasible role of abnormal MEM in colon adenocarcinoma (COAD) is poorly understood. In this work, we obtained COAD patient data from The Cancer Genome Atlas (TCGA) as the training set, and GSE103479 from Gene Expression Omnibus (GEO) as the validation set. Combined with the mitochondrial energy metabolic pathway (MEMP)‐related genes in Kyoto Encyclopedia of Genes and Genomes (KEGG) database, a risk prognostic model was constructed by utilizing Cox regression analysis to identify 6 feature genes (CYP4A11, PGM2, PKLR, PPARGC1A, CPT2 and ACAT2) that were significantly associated with MEMP in COAD. By stratifying the samples based on riskscore, two distinct groups, namely the high‐ and low‐risk groups, were identified. The model demonstrated accurate assessment of the prognosis risk in COAD patients and exhibited independent prognostic capability, as evidenced by the survival curve and receiver operating characteristic (ROC) curve analysis. A nomogram was plotted based on clinical information and riskscore. We proved it could predict the survival time of COAD patients effectively combined with the calibration curve of risk prediction. Subsequently, based on the immune evaluation and mutation frequency analysis performed on COAD patients, patients in high‐risk group had observably higher immune scores, immune activity and PDCD1 expression level than low‐risk group. In general, the prognostic model developed using MEMP‐related genes served as a valuable biomarker for forecasting the prognosis of COAD patients, which offered a reference for the prognosis evaluation and clinical cure of COAD patients.
Spatial tissue proteomics reveals distinct landscapes of heterogeneity in cutaneous papillomavirus‐induced keratinocyte carcinomas
Authors: Schäfer Miriam , Schneider Martin , Müller Torsten , Franz Natascha , Braspenning‐Wesch Ilona , Stephan Sonja , Schmidt Gabriele , Krijgsveld Jeroen , Helm Dominic , Rösl Frank , Hasche Daniel 
Published: June 2023

AbstractInfection with certain cutaneous human papillomaviruses (HPV), in conjunction with chronic ultraviolet (UV) exposure, are the major cofactors of non‐melanoma skin cancer (NMSC), the most frequent cancer type worldwide. Cutaneous squamous cell carcinomas (SCCs) as well as tumors in general represent three‐dimensional entities determined by both temporal and spatial constraints. Whole tissue proteomics is a straightforward approach to understand tumorigenesis in better detail, but studies focusing on different progression states toward a dedifferentiated SCC phenotype on a spatial level are rare. Here, we applied an innovative proteomic workflow on formalin‐fixed, paraffin‐embedded (FFPE) epithelial tumors derived from the preclinical animal modelMastomys coucha. This rodent is naturally infected with its genuine cutaneous papillomavirus and closely mimics skin carcinogenesis in the context of cutaneous HPV infections in humans. We deciphered cellular networks by comparing diverse epithelial tissues with respect to their differentiation level and infection status. Our study reveals novel regulatory proteins and pathways associated with virus‐induced tumor initiation and progression of SCCs. This approach provides the basis to better comprehend the multistep process of skin carcinogenesis.
Genomic and ultrastructural analysis of monkeypox virus in skin lesions and in human/animal infected cells reveals further morphofunctional insights into viral pathogenicity
Authors: Paniz‐Mondolfi Alberto , Reidy Jason , Pagani Nina , Lednicky John A. , McGrail Joseph Patrick , Kasminskaya Yana , Patino Luz H. , Garcia‐Sastre Adolfo , Palacios Gustavo , Gonzalez‐Reiche Ana Silvia , van Bakel Harm , Firpo Betancourt Adolfo , Hernandez Matthew M. , Cordon‐Cardo Carlos , Simon Viviana , Sordillo Emilia M. , Ramírez Juan David , Guerra Susana 
Published: June 2023

AbstractMonkeypox (MPOX) is a zoonotic disease that affects humans and other primates, resulting in a smallpox‐like illness. It is caused by monkeypox virus (MPXV), which belongs to the Poxviridae family. Clinically manifested by a range of cutaneous and systemic findings, as well as variable disease severity phenotypes based on the genetic makeup of the virus, the cutaneous niche and respiratory mucosa are the epicenters of MPXV pathogenicity. Herein, we describe the ultrastructural features of MPXV infection in both human cultured cells and cutaneous clinical specimens collected during the 2022–2023 MPOX outbreak in New York City that were revealed through electron microscopy. We observed typical enveloped virions with brick‐shaped morphologies that contained surface protrusions, consistent with the classic ultrastructural features of MPXV. In addition, we describe morpho‐functional evidence that point to roles of distinct cellular organelles in viral assembly during clinical MPXV infection. Interestingly, in skin lesions, we found abundant melanosomes near viral assembly sites, particularly in the vicinity of mature virions, which provides further insight into virus‐host interactions at the subcellular level that contribute to MPXV pathogenesis. These findings not only highlight the importance of electron microscopic studies for further investigation of this emerging pathogen but also in characterizing MPXV pathogenesis during human infection.
Corrosion of metal parts in the power plant
Authors: Radojković Bojana , Pejić Jovanka , Marunkić Dunja , Simović Anđela , Pantović Sanja Eraković , Jegdić Bore , Bajat Jelena 
Published: June 2023

AbstractThe AISI 304 (X5CrNi19‐10) stainless steel is widely used for the production of various metal parts in power plants. A procedure for testing the influence of the dust from a power plant on resistance to general and pitting corrosion of the AISI 304 stainless steel is developed and performed. The quantitative (XRD method) and qualitative (Fourier–transform infrared spectroscopy [FTIR] method) composition of the dust present in the power plant is determined. Applying the Mott–Schottky method, the properties of the passive layer are analyzed, while a degree of chromium depletion of the grain boundary is determined by the electrochemical potentiokinetic reactivation method with double loop method. Values of polarization resistance (linear polarization resistance and electrochemical impedance spectroscopy methods) and the corrosion current density (polarization measurements) indicate that the stainless steel has a higher resistance to general corrosion in the dust solutions than in the etalon solution. Also, based on the measured value of the pitting potential (Epit) and the difference between the values of the pitting potential and the corrosion potential (Epit – Ecorr), it can be seen that stainless steel has a higher resistance to localized types of corrosion, such as pitting corrosion, in dust solutions than in the etalon solution.
The Effect of a Fish Oil and/or Probiotic Intervention from Early Pregnancy Onwards on Colostrum Immune Mediators: A Randomized, Placebo‐Controlled, Double‐Blinded Clinical Trial in Overweight/Obese Mothers
Authors: Soukka Jenni , Polari Lauri , Kalliomäki Marko , Saros Lotta , Laajala Teemu D. , Vahlberg Tero , Toivola Diana M. , Laitinen Kirsi 
Published: June 2023

ScopeModifying the composition of colostrum by external factors may provide opportunities to improve the infant's health. Here, we evaluated how fish oil and/or probiotics supplementation modify concentrations of colostrum immune mediators and their associations with perinatal clinical factors on mothers with overweight/obesity.Methods and resultsPregnant women were randomized in a double‐blind manner into four intervention groups, and the supplements were consumed daily from early pregnancy onwards. Colostrum samples were collected from 187 mothers, and 16 immune mediators were measured using bead‐based immunoassays.Interventions modified colostrum composition; the fish oil+probiotics group had higher concentrations of IL‐12p70 than probiotics+placebo and higher FMS‐like tyrosine kinase 3 ligand (FLT‐3L) than fish oil+placebo and probiotics+placebo (one‐way analysis of variance, post‐hoc Tukey's test). Although the fish oil+probiotics group had higher levels of IFNα2 compared to the fish oil+placebo group, these differences were not statistically significant after correction for multiple testing. Multivariate linear model revealed significant associations between several immune mediators and the perinatal use of medication.ConclusionFish oil/probiotics intervention exerted a minor effect on concentrations of colostrum immune mediators. However, medication during the perinatal period modulated the immune mediators. These changes in colostrum's composition may contribute to immune system development in the infant.
Retrospective analysis for predictors of postsurgical complications from third molar extraction with use of oxytetracycline–hydrocortisone‐coated gauze inserted in extraction socket
Authors: Matsuda Sayumi , Sato Yoko , Otake Hiroki , Takei Shingo , Nakamura Arihiro , Fukuta Kohta , Abe Atsushi , Adachi Moriyasu 
Published: June 2023

AbstractAimOur previous study proposed a technique of inserting gauze coated with oxytetracycline–hydrocortisone ointment into the extraction socket that suppressed the occurrence of dry socket and post‐extraction pain compared with the gauze‐free group. In this study, we estimated the incidence of dry socket and post‐extraction infection in patients with ointment gauze insertion and identified predictors of post‐extraction pain and change in maximum opening volume.MethodsThis retrospective study was carried out on patients who underwent lower third molar extraction in the Department of Oral Surgery at a general hospital in Japan.ResultsThe incidence of dry socket and infection after tooth extraction was 1.05% and 0.35%. The mean visual analog scale (VAS) on the operative day was 4.15; the VAS for postoperative day (POD)1 and POD7 were 2.28 and 0.55, respectively. The percentage change in maximum mouth opening on POD1 was −9.88%, and that on POD7 was −1.51%. Multivariable analysis indicated that age and Winter position classification were predictors of POD1 VAS, and female sex, smoking, and Winter position classification were predictors of POD7 VAS. Winter position classification and preoperative maximum mouth opening, respectively, were identified as predictors of maximum mouth opening percent change on POD1 and POD7.ConclusionsThe insertion of gauze coated with oxytetracycline–hydrocortisone ointment into the extraction socket of the mandibular third molar showed a low incidence of dry socket and post‐extraction infection. Moreover, the Winter position classification was suggested to be an independent predictor of postoperative pain and the maximum mouth opening percent change.