bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proinflammatory Cytokine Polymorphisms and Severity of Periodontitis in a Cohort of Bulgarian Patients
Authors: Pashova-Tasseva Z. , Popova Ch. , Tosheva E. , Mlachkova A. 
Published: September 2023

Abstract
In this manuscript we are discussing our research of the presence of single nucleotide polymorphisms (SNPs) of two proinflammatory cytokines – interleukin 17F (IF-17F) and interleukin 23 (IL-23) in a cohort of Bulgarian patients.

The aim of the study was to investigate the presence of SNPs of IL-17F and IL-23 and to explore a relation between IL-23 and IL-17F and severity of periodontitis. In the study 83 individuals were included – 62 patients with severe periodontitis and 21 healthy participants. Detailed periodontal status was taken in order to estimate the diagnosis of each participant. A Real-Time PCR for determination of SNP of IL-17 and IL-23 was performed. The data was summarised and processed by the means of statistical analysis.

The results showed that when testing individuals for SNP of IL-17F, three genotypes were detected – TT, CT, CC, with prevalence of the TT genotype. In regards to SNP of IL-23, the widespread distribution of GG genotype represents the major share among all individuals with only three representatives with GA genotype. Important tendencies about the severity of the periodontal disease with regards to the SNPs and their simultaneous presence were found.

Conclusion: In the present study two proinflammatory cytokine gene polymorphisms were explored and studied in relation to the severity of the periodontal disease. Their distribution among the tested individuals was established and relation to major parameters of the periodontal disease was evaluated.
Giant Lipoma of the Hand
Authors: Georgiev G. P. , Telang M. , Firoozi B. , Ananiev J. , Landzhov B. , Olewnik Ł. , Stokov L. 
Published: September 2023

Abstract
Lipomas have been called “innocent tumors” due to their slow growth without infiltrating neighbouring structures, usually with a rounded or ovoid shape, rarely over 2 cm in size. In the area of the upper limb, lipomas over 5 cm are defined as “giant lipomas”. In this report, we present a rare case of a “giant lipoma” in the hand in a 60-year-old man. He complained of painless swelling, which appeared eight years before and gradually increased in size until the last year, when a significant enlargement appeared; thus, the soft tissue mass led to the inability to perform daily tasks, and the patient sought medical care. Computed tomography suggested the diagnosis of lipoma. Thereafter, successful surgical excision was performed, and no recurrences were observed two years after the operation. The clinical signs, imaging, and treatment methods of this case are briefly presented.
Interprofessional education: the attitude among students of health science bachelor's degree programmes at universities of applied sciences in Austria / Interprofessionelle Ausbildung: Die Einstellung der Studierenden gesundheitswissenschaftlicher Bachelor-Studiengänge an österreichischen Fachhochschulen
Authors: Kühteubl Monika , Pekar Thomas 
Published: September 2023

Abstract

Introduction
Interprofessional collaboration is a strategy to meet the challenges of increasing complexity in the health system. The basis for cooperation in professional life must already be established in the context of interprofessional education (IPE). Students’ attitude towards IPE is a crucial factor in the development of interprofessional competences.
The aim of this study is to investigate the attitude towards interprofessional education among students of health science bachelor's degree programmes at selected universities of applied sciences in Austria.

Method
An empirical, quantitative, non-experimental approach in the form of a cross-sectional study was chosen, with the survey being carried out online using the questionnaire University of the West of England Interprofessional Questionnaire © (Pollard et al., 2004) in its German translation von Mahler et al. (2017), as a self-assessment measuring instrument to investigate the students’ attitude towards communication and teamwork, interprofessional learning and interprofessional interaction. The data evaluation was both descriptive and analytical.

Results
505 students from nine different health science degree programmes participated in the survey. 79 % (n = 504) rate their communication and teamwork skills positively and 76.6 % (n = 505) have a positive attitude towards interprofessional learning. However, only 8 % (n = 396) have a positive opinion on interprofessional interaction. In the group comparisons, significant differences are observed between the various study programmes, semesters of study and previous professional experience.

Conclusion
The knowledge of the attitude towards IPE should be considered when designing interprofessional activities during the course of studies in order to influence the students’ attitude positively.
Regional and local border effects after two decades of Central European unification. What matters?
Authors: Neumannová Michaela , Pařil Vilém , Hrůza Filip , Jakubčinová Martina , Farbiak Martin 
Published: September 2023

Abstract
This article deals with the border effect phenomenon affecting the mobility of inhabitants in border regions. It aims to identify the determinants of the border effect in transport at the municipal level, considering the distance from the border, the populations and the characteristics of the closest bordering country. The survey in the Czech Republic eventually involved 675 representatives of municipalities who answered questions on inter-municipal mobility. The results confirmed that the most substantial handicap was population size, with small populations corresponding to the limited use of public transport when travelling beyond a given border. The results confirmed that the characteristics of the state or region that shares the border must be considered when assessing border regions. Therefore, the solution to the problems of individual border regions cannot be viewed with a single instrument. It is necessary to consider substantial differences resulting from the economic level of neighbouring countries.
Autonomous Vehicles and the Linkages to Smart Mobility: Impact and Implications on Digital Globalisation
Authors: Reghunadhan Ramnath , Stanley Ansel Elias 
Published: September 2023

Abstract
Human civilisation is undergoing a transformation, perceived as the institutionalisation of digital globalisation. The 20th century witnessed greater strides in the form of the internet revolution, automobile technologies and smart mobility, related transformation, dissemination and integration of related technologies as well, leading to the emergence of digital globalisation. The integration of cyber-physical systems has accelerated the rate of urbanisation, and the currently prevailing enhanced standards of living have increased the number of automobiles in cities that have been integrated into the digitally globalised ecosystems, leading to the emergence of autonomous vehicles (AVs). The present study analyses the emerging threats and vulnerabilities of AVs and smart mobility, which have created more security concerns for AVs across nation-states, leading as well to the emergence of digital globalisation. The article theorises the aspects of human security linkages and utilises a capacity matrix (qualitative approach) to examine the development, institutionalisation and integration of AVs into digital globalisation and the related challenges emerging along with it.
Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure
Authors: Vlajovic Sladjana , Andrejic Olivera , Sreckovic Miodrag , Davidovic Goran , Bankovic Dragic , Milovanovic Nada , Vucic Rada 
Published: September 2023

Abstract
NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.
Is the likelihood of receiving cataract surgery determined by place of residence? A systematic review and meta-analysis
Authors: Fachir Farisa Shauma , Arifin Syamsul , Febriana Silvia Kristanti Tri , Wanahari Tenri Ashari 
Published: September 2023

Objectives:
This study aims to systematically review the literature and identify the association between place of residence and cataract surgery utilisation.

Materials and Methods:
We conducted a systematic review and meta-analysis according to preferred reporting items for systematic review and meta-analysis guidelines. A literature search was performed on PubMed and ProQuest databases, screening all related articles in the past 10 years (2012–2022). Data were analysed using RevMan 5.3 software, with pooled effect estimates reported as an odds ratio (OR) with a 95% confidence interval (CI).

Results:
A total of 10 studies from eight articles were identified and included in the meta-analysis. The pooling results of these studies suggest that there is a statistically significant association between residence and cataract surgery utilisation. Those who live in rural areas (OR: 0.70, 95% CI: 0.52–0.95, P = 0.02) are 0.7 times less likely to use cataract surgical services compared to urban areas. The heterogeneity was significant (P < 0.0001 and I2 = 76%) and a random effect model was adopted.

Conclusion:
Our findings indicate that there is an association between place of residence and cataract surgery utilisation, with individuals residing in rural areas being less likely to use such treatment. These findings can inform targeted interventions aimed at improving cataract surgical coverage among rural populations.
Identificación cultural y emocional con Madrid a través de la serie Valeria (Netflix, 2020-2023)
Authors: Higueras Ruiz María José 
Published: September 2023

Los servicios de VoD —video on demand— favorecen la configuración de un mercado televisivo global en la industria audiovisual contemporánea. El carácter trasnacional del operador de Netflix permite la distribución internacional de series de ficción producidas localmente y, con ello, la transmisión de identidades culturales nacionales en un contexto global. El presente artículo[1] se dirige a determinar la representación de la idiosincracia nacional española a través de las imágenes de la ciudad de Madrid incluidas en la serie de producción original de Netflix: Valeria (2020-2023). Se aplica una metodología cualitativa basada en la revisión bibliográfica de trabajos previamente publicados y el examen de la citada ficción. Con este fin se elabora una tabla de análisis con los datos técnicos, la identificación cultural y emocional, y el lenguaje audiovisual de las escenas que muestran localizaciones de la ciudad. Los resultados revelan la inclusión de exteriores y arquitecturas, locales de actividad económica y símbolos identitarios a través de imágenes que articulan las tramas personales y profesionales de los personajes con una cuidada realización audiovisual. Las conclusiones evidencian la proximidad cultural para la audiencia local y las opciones turísticas de la ciudad de Madrid a través de la serie y su material promocional.

[1] Este artículo ha sido escrito en el marco del proyecto de la Conserjería de Universidad, Investigación e Innovación de la Junta de Andalucía y FEDER, Una manera de Hacer Europa/Proyecto (B-SEJ-370-UGR20) “La industria cinematográfica andaluza en el HIPERSECTOR AUDIOVISUAL-TIC: retos y oportunidades” (CINATIC). Investigadores Principales: Francisco Javier Gómez-Pérez y Jordi Alberich Pascual.
Currency Substitution and General Business Indicators in Nigeria
Authors: Adekunle Ahmed Oluwatobi 
Published: September 2023

Purpose: This paper examines the effects of currency substitution on general business indicators in Nigeria.

Theoretical framework: This paper is based on portfolio balance theory which is concerned with interest rate adjustment and achieving the market equilibrium on currency substitution aggregate.

Design/Methodology/Approach: The paper employed appropriate econometric techniques such as the cointegration and error correction model (ECM) approach to examine the long run and short run attendant relationships.

Findings: Empirical findings from this study indicate that there is a long run relationship between currency substitution and general business indicators variables as inflation, interest rate differentials, and exchange rate depreciation in Nigeria, the magnitudes of the impact of each are weak.

Research, Practical & Social implications: The construction and analysis of currency substitution and general business environment by this study have provided relevant information for Nigerian economy in preparing for substantial currency substitution that would give clear understanding of the aggregate business environment on existing currency substitution policy that may lessen the anxiety of the apparent environmental challenges faced by the countries, and this will further provide policy directions for future currency substitution reforms in the various segment of the economy.

Originality/Value: The originality of this study lies in its analysis of currency substitution and general business environment. Furthermore, the study highlights the relevance of tackling regulatory issues to ensure the safe and effective use of currency substitution.
Procesos de digitalización, seguimiento de la información política y cambios en la cultura política de América Latina
Authors: Cazorla Martín Ángel 
Published: September 2023

El presente trabajo analiza los procesos de digitalización en América Latina a lo largo de los últimos años, al mismo tiempo que su relación con los cambios en las dinámicas de seguimiento de la información y participación política. En primer lugar se realiza una caracterización de los cambios en la cultura política de la región, teniendo en cuenta tanto sus factores estructurales como condicionantes subjetivos y cognitivos, prestando especial atención a la confianza y satisfacción política e institucional. En segundo lugar se presenta el estado de la cuestión sobre los medios de comunicación en la región y su relación con la cultura política para así profundizar en algunas de las dinámicas de participación política ciudadana y sus cambios a partir de los nuevos medios digitales. Posteriormente se analizan los resultados del trabajo de campo, obtenidos a partir de la recopilación de datos de sucesivas oleadas del Latinobarómetro[1].
En relación a los procesos de digitalización y al uso de medios digitales para la información política, los resultados muestran el gran avance que ha tenido la región, al mismo tiempo que pone de manifiesto las grandes diferencias entre países, encontrando como principal variable explicativa el desarrollo económico. En cuanto a la relación entre los componentes de cultura política tenidos en cuenta y el uso de medios digitales para la información política, los resultados muestran el papel que tanto la confianza institucional como la satisfacción democrática juegan en el uso político de medios digitales.

[1] Se ha realizado el análisis de las series del Latinobarómetro en las cuales se indaga al respecto del seguimiento de la información política a través de medios digitales, Internet y Redes Sociales. La última oleada del Latinobarómetro (referente al año 2020 y publicada en noviembre de 2021) ha eliminado las variables referidas a esta cuestión, condicionando por ello el fin de la serie al año 2018.
The Differences of Male and Female Students’s Problem Solving Ability in Environmental Change Topic Based on Education for Sustainable Development (ESD)
Authors: Budianti Dewi Arum , Nugroho Ary Susatyo , Hayat Muhammad Syaipul 
Published: September 2023

This study aims to determine the differences between male and female students’s problem solving abilities in environmental change topic based on ESD. This study used pre-experimental method with one group pretest – post test design. This study located at MA Darul Muqorrobin with subjects 30 students of class X who selected using a purposive sampling technique. Generally, female students’s problem solving ability is higher than male student’s, with a final value of 77.7 for male students and 82.3 for female students. Male students have an average total score higher than female students on the problem understanding indicator, namely 7.7 for male students and 7.4 for female students. In the problem-solving design indicator, female students have a higher average total score than male students, namely 6.1 for male students and 6.5 for female students. Female students have an average total score higher than male students on the indicator of carrying out problem solving, namely 5.8 for male students and 6.4 for female students. In the indicators evaluating problem solving, female students have an average total score higher than male students, namely 5.3 for male students and 5.9 for female students. The high female students’s problem solving ability due to the structure of woman’s corpus collasum which thicker than the men’s. Testosterone hormone causes men prefer learning that hands-on. The preoptic region in the men’s hypothalamus is larger than women’s so men can understand problem better than women. The interpretation of the N-Gain value is sufficient, so the learning of environmental change topic based on ESD is effective to improve problem solving ability in both students.
INDICATORS OF AUTONOMIC REGULATION OF THE HEART IN YOUNGER SCHOOL CHILDREN WHO EXPERIENCED THE STRESS OF MILITARY OPE
Authors: Ershova Irina 
Published: September 2023

The autonomic nervous system is particularly susceptible to stress. The results of a study of
prospective features of heart rate variability in primary school children who have experienced the stress of
military operations are presented. 128 children of primary school age who found themselves in the zone of
active hostilities were under observation. The assessment of vegetative functions was carried out by analyzing
the components of heart rate variability. The younger students of the Io group had a more pronounced sym pathicotonia already a year after the start of the stress factor exposure. By the end of the third year, the sym pathicotonic orientation of the regulation of the heart rhythm was replaced by vagotonic in children living in
the territory of the stressful situation of the war. The peculiarities of vegetative regulation in children who are
and have left the combat zone indicate an increase in the costs of the functional reserve to maintain the normal
level of functioning of the body
Problem-based learning method in the context of a flipped classroom: Outcomes on pain management course acquisition
Authors: Merrou Soumia , Idrissi Jouicha Abdellah , Baslam Abdelmounaim , Ouhaz Zakaria , El Adib Ahmed Rhassane 
Published: September 2023

Introduction: A deep understanding of physiology, physiopathology, pharmacology, and the management of pain is crucial for nurse anaesthetists to ensure the well-being of their patients. Thus, the teaching strategies should enhance the transition from acquiring the fundamental pain phenomena, to developing translational and critical thinking. The aim of the study is to determine if the flipped classroom that is considered an active learning approach is most effective compared to the traditional method in teaching pain management and if it improves students' academic performance.
Methods: This study was quasi experimental, at a higher institute of nursing professions, among third-year anaesthesia resuscitation nursing students. participants were randomly allocated into either: the flipped classroom group where PBL was used (FG, n = 19), or the traditional lecture-based classroom group (TG, n = 19). The results and impact of the above approach were appreciated via the analysis of the summative assessment of the class group and from the questionnaire submitted to students.
Results: The present study revealed that in the midterm exam, the mean score of the flipped classroom group (14.0) which is significantly higher (p<0.01) than the traditional lecture group (11.9). Moreover, the standard deviation of this latter is slightly higher (2.41) which indicates scores far from the average. Also, a significant difference between the averages of the two approaches in favor of flipped classroom Group was revealed (p<0.01).
Conclusion: The assessment of student’s grades and their appreciation of both teaching approaches showed a preference for the PBL.

Keywords:	Flipped Classroom, Nursing Education, Pain Management, Problem-Based Learning
Remote learning readiness amidst the COVID-19 pandemic amongst undergraduate medical students
Authors: Tan Kit Mun , Foong Chan Choong , Adams Donnie , Hong Wei Han , Lee Yew Kong , Pallath Vinod 
Published: September 2023

Introduction: The global COVID-19 pandemic had greatly affected the delivery of medical education, where institutions had to convert to remote learning almost immediately. This study aimed to measure undergraduate medical students’ readiness and factors associated with readiness for remote learning.
Methods: A cross-sectional quantitative study was conducted amongst undergraduate medical students using the Blended Learning Readiness Engagement Questionnaire, during the pandemic where lessons had to be delivered fully online in 2020.
Results: 329 students participated in the study. Mean scores for remote learning readiness were 3.61/4.00 (technology availability), 3.60 (technology skills), 3.50 (technology usage), 3.35 (computer and internet efficacy), and 3.03 (self-directed learning). Male students appeared more ready for remote learning than females, in the dimensions of self-directed learning and computer and internet efficacy. Students in the pre-clinical years showed a lower level of readiness in the technology availability domain compared to clinical students. The lowest score however was in the self-directed learning dimension regardless of the students’ year of studies.
Conclusion: The pandemic had created a paradigm shift in the delivery of the medical program which is likely to remain despite resumption of daily activities post-pandemic. Support for student readiness in transition from instructor-driven learning models to self-directed learning models is crucial and requires attention by institutions of higher learning. Exploring methods to improve self-directed learning and increase availability of technology and conducting sessions to improve computer and internet efficacy can be considered in the early stages of pre-clinical years to ensure equitable access for all students.

Keywords:	Remote Learning, Student’s Readiness, Medical Education