bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOXOPLASMA GONDII (NICOLLE & MANCEAUX, 1908) NO ES LIBERADO EN LAS HECES DE LAS AVES
Authors: Traviezo-Valles Luis Eduardo 
Published: February 2023

Estimado Editor, leyendo con detenimiento un interesante artículo de la revista Biotempo intitulado “La paloma, Columba livia (Gmelin, 1789): biología, deterioro estructural y principales enfermedades zoonóticas” (Ramos et al., 2021), sobre el mismo quisiera hacer algunas consideraciones.
La toxoplasmosis es considerada la zoonosis de mayor expansión mundial, ya que su agente etiológico (parásito eurixéno o eurioíco) ha sido demostrado en humanos y en más de 363 especies de animales homeotermos, específi camente en 330 especies de mamíferos domésticos y salvajes, más 33 especies de aves de corral y silvestres (Pantoja & Pérez, 2001; Triolo & Traviezo, 2006; Zhang et al., 2018).
Encéphalopathie anoxo-ischémique du nouveau-né à terme : particularités en Afrique subsaharienne
Authors: Akaffou A.E. , Cardenat M. , Ake Assi Konan M.H. , N’Guessan-Sika R. , Oussou E.A.O.V. , Amon Tanoh-Dick F. 
Published: February 2023

Introduction : L’encéphalopathie anoxo-ischémique du nouveau-né à terme reste très fréquente en Afrique. Notre étude a pour objectif d’identifier ses particularités dans la zone subsaharienne afin d’en déduire les actions adaptées permettant d’en réduire la morbidité et la mortalité.
Méthodes : Il s’agit d’une étude prospective transversale menée du 1er mars au 31 mai 2019 à Abidjan en Côted’Ivoire. Ont été inclus, avec le consentement éclairé des parents, les nouveau-nés à terme, hospitalisés au centre hospitalier universitaire (CHU) de Yopougon à Abidjan, pour un diagnostic d’encéphalopathie anoxo-ischémique (EAI) retenu devant l’existence d’un score d’APGAR inférieur à 7 en cinq minutes, la présence d’un ou de plusieurs signes neurologiques à la naissance et l’existence d’un contexte d’asphyxie périnatale. Les nouveau-nés issus d’une grossesse multiple et/ou ayant une malformation de l’axe neuroméningé n’ont pas été inclus.
Résultats : La prévalence de l’EAI était de 24,5 %. Les particularités relevées étaient le recours aux ocytociques traditionnels au cours du travail chez 58,3 % des parturientes, le retard à l’admission au-delà de H6 de vie pour 55,6 % des patients, la fréquence élevée d’une détresse respiratoire (73,6 %), une prise en charge comportant le maintien initial en hypothermie passive et un traitement symptomatique. La mortalité était de 22,2 %, le risque de décès étant lié au grade III de SARNAT (p = 0,0001) et à un nombre de consultations prénatales inférieur à 4 (p = 0,01).
Conclusion : Ces particularités sont à considérer pour la mise en œuvre d’interventions efficaces et adaptées, afin de réduire la morbimortalité de l’EAI du nouveau-né à terme en Afrique subsaharienne.
Centro e periferia no discurso do rei Agrippa II: uma interpretação Josefiana sobre a dominação Romana na Era Flaviana (Século I E.C.)
Authors: Passuello Victor 
Published: February 2023

A partir da Era Flaviana é possível observar uma transição do poder político romanos, antes centrado no imperador e na cidade de Roma. Essa transição, leva-nos a identificar uma nova ordem do poder político, que passa a ser proveniente das legiões romanas e seus generais. Assim depõe Josefo, em sua obra A Guerra dos Judeus, ao publicar o discurso do rei Agrippa II. A hegemonia romana será aqui analisada à luz do conceito geográfico e político de centro/periferia. O exército romano, espalhado nas províncias, passa a definir os aspectos geográficos e até religiosos, do império, diferentemente do que ocorria na Era Júlio-Claudiana. O artigo também discutirá a ausência de um poder fixo, personificado nas legiões romanas que estavam em movimento, refletindo uma concepção religiosa pagã e também judaica, definida como quietista. Uma concepção teológica que pode ser relacionada à tradição grega da deusa Fortuna, como descrita pelo historiador grego Políbio. Josefo, também um quietista, era contrário à guerra contra os romanos, porém igualmente demonstrava uma crítica à dominação romana da Era Flaviana.
Palavras-chaves: Império Romano. Agrippa II. Centro-periferia. Quietismo.
A Sacrament of Intellectual Self-Gratification
Authors: Doja Albert 
Published: February 2023

Abstract
Agamben claimed that the experience of language, as it is manifested in the oath, precedes and gives rise to religion, law and politics, and therefore should be seen as a crucial element of the human process. It is my contention to argue here that a particular aspect of Agamben's own language suffers from substantial and conceptual flaws and self-assertive opinions on language and oath. They may put in question his own engagement with the textual evidence and philosophical literature, which makes his own text self-recommending and self-gratifying. In addition, he relied on obscure authors and obsolete interpretations and he failed to engage the relevant issues in the relevant literature that are crucial to his argument. More importantly, Agamben's argument on a certain impotence of language offers little suggestion, except calling upon philosophical obfuscation, to break down the state of exception in the current post-modern condition and avoid the technical apparatuses of the sacrament of power that led first to oath, and then to religion, law and politics.
The Construction of Muslim Women Characters in Early English Drama
Authors: Abdul Muttaleb Fuad , Odeh Mai Rushdi 
Published: February 2023

Abstract
This article examines the portrayal of Islam and Muslim women in Renaissance England by considering the historical framework and the changes in the attitudes towards Islam at that time. It contends that Renaissance drama has presented Islam as the Other and the Muslim world as antithetical to Christendom. This article examines two specific Muslim women characters in two early English plays, Queen Tota in Thomas Heywood's The Fair Maid of the West Parts I and II, and the Turkish queen in George Peele's The Battle of Alcazar. The work relies on the ideas of several critics, historians and theorists in its analysis of these dramatic works. The two texts are read from a New Historicist perspective. Historical, socio-political and economic factors prevalent during the time are brought back to life and the plays will be explored in light of these.
Constructing Childhood through Remembrance in Selected Short Stories by Alice Munro
Authors: Abdulmuttalib Zeinab 
Published: February 2023

Abstract
This article attempts to study a selection of short stories by the contemporary Canadian writer Alice Munro (1931–) focusing on the theme of childhood. It examines the representation of childhood as remembered by adult narrators. The research approaches the stories through the theories of narratology and psychoanalysis. The concepts of the narrator in addition to Freud's theorisation about childhood memories are especially utilised to explore the childhood memories of the adult narrators. The stories selected for this study are ‘The Ottawa Valley’ (1974), ‘Chaddeleys and Flemings’ (1979), ‘The Progress of Love’ (1985) and ‘The Eye’ (2012) with adult narrators.
Jabung Village Dairy Farmers: Milk Education Center
Authors: Ifit Novita Sari  , Fajarianto Otto , Kurniawan Citra , Wulandari Tri Candra , Marlina Ena 
Published: February 2023

Abstract
Jabung village has a fairly high number of dairy farmers compared to other livelihoods, such as employees, farmers and laborers. This is a great potential for the village to become a special tourism village on dairy farmer edutourism. Currently, the village government is taking inventory of various potential villages that are developed to become tourist villages. The inventory is carried out in stages in line with the activities of the Regrestrasi Awal Sosial Ekonomi (regrosek) specifically for the economy in 2022. The purpose of this service activity is based on the village government's desire to empower a number of dairy farmers to become learning centers for other farmers outside Jabung Village. Preparation is carried out by fixing various supports for the maintenance of dairy cattle. Starting from feeding to milking. Stimulation in the form of animal feed chopping tools, electric cow milking, and the creation of a website following e-learning about dairy cattle.
Keywords: edutourism, dairy farmers, e-learning

Abstrak
Desa Jabung memiliki jumlah peternak sapi perah cukup tinggi dibanding dengan mata pencarian hidup lainnya, seperti pegawai, petani dan buruh. Hal ini menjadi potensi besar bagi desa untuk menjadi desa wisata khusus pada eduwisata peternak sapi perah. Saat ini pemerintah desa sedang menginventarisir berbagai potensi desa yang dikembangkan untuk menjadi desa wisata. Inventarisasi dilakukan bertahap sejalan dengan kegiatan Regrestrasi Awal Sosial Ekonomi (regrosek) khusus ekonomi tahun 2022. Tujuan kegiatan pengabdian ini berlatar pada keinginan pemerintah desa untuk memberdayakan sejumlah peternak sapi perah untuk menjadi pusat belajar bagi para peternak lain di luar Desa Jabung. Persiapan dilakukan dengan membenahi berbagai penunjang pada pemeliharaan ternak sapi perah. Mulai dari pemberian pakan hingga pemerahan susu. Stimulasi berupa alat pencacah pakan ternak, pemerah susu sapi elektrik, dan pembuatan website berikut e-learning tentang ternak sapi perah..
Kata kunci: eduwisata, peternak sapi perah, e-learning
Characterization of Depressive Symptoms in Dementia and Examination of Possible Risk Factors
Authors: Sinclair Lindsey I. , Lawton Michael A. , Palmer Jennifer C. ,   for the Alzheimer’s Disease Neuroimaging Initiative, Ballard Clive G. 
Published: February 2023

Background: Depression in individuals with Alzheimer’s disease (AD) is common, distressing, difficult to treat, and inadequately understood. It occurs more frequently in AD than in older adults without dementia. The reasons why some patients develop depression during AD and others do not remain obscure. Objective: We aimed to characterize depression in AD and to identify risk factors. Methods: We used data from three large dementia focused cohorts: ADNI ( n = 665 with AD, 669 normal cognition), NACC ( n = 698 with AD, 711 normal cognition), and BDR ( n = 757 with AD). Depression ratings were available using the GDS and NPI and in addition for BDR the Cornell. A cut-off of≥8 was used for the GDS and the Cornell Scale for Depression in Dementia,≥6 for the NPI depression sub-scale, and≥2 for the NPI-Q depression sub-scale. We used logistic regression to examine potential risk factors and random effects meta-analysis and an interaction term to look for interactions between each risk factor and the presence of cognitive impairment. Results: In individual studies there was no evidence of a difference in risk factors for depressive symptoms in AD. In the meta-analysis the only risk factor which increased the risk of depressive symptoms in AD was previous depression, but information on this was only available from one study (OR 7.78 95% CI 4.03–15.03). Conclusion: Risk factors for depression in AD appear to differ to those for depression per se supporting suggestions of a different pathological process, although a past history of depression was the strongest individual risk factor.
PENGARUH KOMBINASI SENAM LANSIA DENGAN BERDIRI JINJIT TERHADAP PENURUNAN NYERI SENDI PADA LANSIA
Authors: Marwiati Marwiati , Mustajab Abdullah Azam , Khoiriyah Siti 
Published: February 2023

The elderly is an individual who experiences various deteriorations of organ function so that it is susceptible to diseases and infections. Joint pain is a chronic complaint of the elderly, the main pain occurs when waking up in the morning which makes the elderly even more unproductive. The experimental quasy study was used in this study with post test only control design approach for the elderly given routine elderly gymnastics by combining with tiptoe standing. The results of the study found that the elderly experienced a decrease in joint pain, the joint muscles of the legs became more flexible and because the elderly gymnastics was carried out together, the elderly became happier so that they felt more comfortable. The combination of physical therapy of elderly gymnastics, gathering together with peers and music rhythms is a psychosocial impact that can reduce pain in addition to walking in place and tiptoe standing can train muscle strength and flexibility.
ANALISIS PELUANG BANK SYARIAH INDONESIA (BSI) MENJADI TOP 5 BANK DI INDONESIA BERDASARKAN KEKUATAN ASET DAN VISI MISI
Authors: Kunaifi Aang , Ali Said Achmad , Mawardi Ahmad 
Published: February 2023

Tujuan organisasi perusahaan dapat dicapai melalui beberapa strategi yang digunakan dalam menentukan keunggulan bersaing yaitu dengan menggunakan berbagai macam strategi yakni dengan mengedentifikasi faktor internal dan eksternal perusahaan yang diantaranya peran tenaga kerja atau karyawan . Selain itu juga melakukan pengembangan layanan suatu produk melalui digitalisasi yang lebih fleksibilitas dan nyaman untuk nasabah seperti halnya penggunaan single system yang artinya sekarang Bank Syariah Indonesia memiliki satu core banking system, satu enterprise data, satu sandi kode bank 451, dan satu pelaporan keuangan, semua dengan nama Bank Syariah Indonesia (BSI). Penelitian ini bertujuan untuk mengukur peluang BSI dalam mencapai target menjadi 5 besar dalam industry perbankan nasional. Penelitian ini merupakan penelitian dengan pendekatan deskriptif kualitatif. Penelitian ini di laksanakan di Bank Syariah indonesia KCP Molyosari Surabaya, subjek penelitian ini adalah Brance Manager (BM), Mikro Relationship and Manager Tim Leader (MRMTL), Consumer Bussines Staf (CBS), Custumer Service (CS), Branch Operation and Servis manager (BOSM). Metode pengumpulan data dalam penelitian ini menggunakan wawancara, observasi, dan dokumentasi, kemudian dianalisis secara kualitatif deskriptif. Melalui temuan dalam penelitian ini diharapkan diperoleh strategi yang tepat dan terukur dalam mencapai targaet 5 besar perbankan di Indonesia
Determination of Cr, Se, Ge, and V in Hypothyroidism Patients by Using Graphite Furnace Atomic Absorption Spectrometry and mixture matrix modification
Authors: Halah Hamid Hammadi  
Published: February 2023

A simple, accurate and rapid method was developed for routine determination of trace elements in blood serum. The method based on the direct determination for Cr, Se, Ge, and V in hypothyroidism patients before therapy. By using atomic absorption spectrometry with graphite surface coated and uncoated pyrolysis GF-AAS, and a mixture of palladium nitrate and magnesium nitrate as the matrix modifier, with deuterium background correction and no sample pretreatment except dilution was necessary. This permitted direct determination hence the risk of sample contamination was reduced. Further, the use of graphite surface-coated GF-AAS decreased the ashing and atomization temperatures of Cr, Ge, and V to values that were lesser than the corresponding values obtained using uncoated pyrolysis GF-AAS, by 100°C; in case of Se, the atomization temperature decreased to a value that was 200°C lesser than that obtained using uncoated pyrolysis GF-AAS.
A mixture of (3µL) palladium nitrate, and (2µL) magnesium nitrate was successfully applied to improve the sensitivity, reproducibility, recovery, limit of detection and the accuracy of the measurements. The correlation coefficients of the calibration curves of Cr, Se, Ge, and V were found to be (0.9999, 0.9999, 0.9995 and 0.9999) respectively, the relative standard deviation of the measurements for Cr, Se, Ge and V were (0.027, 0.075, 0.054 and 0.068) respectively. The statistical analysis of the acquired data showed acceptable accuracy. The analyses thus performed indicated that the levels of serum trace elements Cr, Se, Ge, and V in hypothyroidism patients were lower than those in the control group.
Factores de riesgo cardiovasculares relacionados con la diabetes mellitus tipo 2: Revisión sistemática
Authors: Ortiz Atiencia Gissela Vanesa , Salas Contreras Francy Hollminn 
Published: February 2023

Introducción. La diabetes mellitus tipo 2 (DM2) en los últimos años ha sido considerada como una patología de amenaza para la salud mundial debido a sus complicaciones cardiovasculares, las cuales provocaron el incremento de los índices de prevalencia y mortalidad. Objetivo. Examinar en la literatura científica sobre los factores de riesgo cardiovasculares relacionados con la diabetes. Metodología. Se realizo una revisión sistemática de publicaciones en los siguientes exploradores: Pubmed, Scopus, Web of Science, desde el año 2017, se escogieron aquellos que tuvieron alguna relación con la temática a tratar, de forma complementaria esta búsqueda se realizó utilizando las palabras claves: riesgo cardiovascular, diabetes mellitus, prevalencia, hipertensión, obesidad. Resultados. Se encontró un total de 24 artículos relacionados con el tema que reflejaron que la hipertensión arterial, hipercolesterolemia, hiperglicemias, la obesidad y el tabaquismo obesidad fueron factores de riesgo cardiovasculares relacionados con la diabetes. Conclusión. Al ser la diabetes mellitus tipo 2 de importancia mundial debido a sus índices de morbi-mortalalidad fue importante estudiarla y definir los diferentes factores de riesgo cardiovasculares relacionados con esta patología. Área de estudio: Enfermería
Manejo de hematoma subdural crónico: caso clínico
Authors: Uyaguari Yunga María Isabel , Torres Criollo Larry Miguel 
Published: February 2023

Introducción: El hematoma subdural crónico es una enfermedad caracterizada por una colección de sangre en el espacio subdural (duramadre y aracnoides), es uno de los tipos de hemorragia subaracnoidea con más frecuencia y si se les brinda el tratamiento correcto a los pacientes con esta patología tienen un diagnóstico favorable. Objetivo: determinar el manejo de hematoma subdural crónico en un paciente de 62 años del Hospital San José en la Ciudad de Azogues. Descripción caso clínico: Paciente de 62 años, sexo masculino, casado, procedente de Tulcán, residente en cuenca- Ecuador, con instrucción primaria, ocupación albañil, raza mestiza, religión testigo de jehová, tipo de sangre ORH +. Con diagnóstico de hematoma subdural crónico, con antecedentes patológicos ninguno. Evolución: Paciente después del procedimiento quirúrgico pasa a sala de recuperación con medidas posquirúrgicas y luego pasa sala respectiva con medidas anti edema cerebral, solución salina al 0.9%, anticonvulsivante, antibiótico, analgésicos, además corticoides, tras un día de recuperación paciente es dado de alta en buenas condiciones, vigil y orientado en tiempo ,espacio y persona con escala de Glasgow 15/15, pupilas fotorreactivos , isocóricas, y se retira dren bajo normas de asepsia y antisepsia y se sutura, y se envía al paciente a domicilio con tratamiento farmacológico ambulatorio. Conclusión: Tal fue el caso clínico expuesto, asegurando de esta manera el bienestar físico, mental y social del individuo.
Preclinical Evaluation of a New Anti-COVID-19 Intravenous Immunoglobulin
Authors: Nikolaeva A. M. , Ivanov A. V. , Smolyanova T. I. , Razumikhin M. V. , Belyakova O. V. , Shilova E. G. , Selezneva N. R. , Vyaznikova T. V. , Semicheva A. I. , Sakanyan E. I. 
Published: February 2023

Introduction. Using of immunoglobulins containing SARS-CoV-2 neutralizing antibodies may be an effective and safe tool for COVID-19 treatment. An intravenous immunoglobulin COVID-globulin from donor blood plasma containing SARS-CoV-2 neutralizing antibodies was developed at Joint-Stock Company Nacimbio.Aim. A pilot study of the safety of the "COVID-globulin".Materials and methods. When studying the safety of the preparation in animals the following parameters were evaluated: general toxicity, thrombogenic potential, influence on hematological and biochemical parameters, blood clotting and hemolytic activity, determination of local irritant action, pyrogenic properties, bacterial endotoxins, allergic effect of the drug preparation and its physicochemical characteristics.Results and discussion. Safety studies of "COVID-globulin" in animals showed no signs of intoxication, local irritant action and thrombogenic properties. Macroscopic and histological examination of the organs of rats treated with COVID-globulin showed no signs of necrosis, inflammation, atypia, or any significant pathological changes. Hematological and biochemical parameters of the blood of laboratory animals after the administration of "COVID-globulin" corresponded to the reference values. Administration of COVID-globulin to rabbits did not activate blood clot formation. The IgG subclasses distribution in the preparation corresponded to that in human plasma. The activity of the Fc-function of the immunoglobulin molecule was more than 130 % compared to the reference standard preparation, the concentration of the prekallikrein activator in the COVID-globulin ranged from 4.2 to 4.8 IU/ml, anticomplementary activity was less than 1 unit complement per 1 mg of protein.Conclusion. The results of all studies have demonstrated a high level of safety of the developed COVID-globulin preparation, which meets the safety requirements for human immunoglobulins for intravenous administration by national regulatory documents and the European Pharmacopoeia.
Obtaining a Water-soluble Form of Hydrophobic Indolelocarbazole Derivative Using Solubilizer Complex
Authors: Kolpaksidi A. P. , Dmitrieva M. V. , Nikolaeva L. L. , Orlova O. L. , Krasniuk I. I. 
Published: February 2023

Introduction. LHS-1269 is an indolocarbazole derivative with high antitumor activity. Due to the hydrophobic properties of the active substance, the use of organic co-solvents – dimethyl sulfoxide (DMSO) and ethanol – is required to obtain an injectable dosage form (DP). However, the inclusion of organic solvents in the composition of the DF carries a potential risk of side effects as a result of the use of the drug.Aim. Selection of auxiliary substances for obtaining an aqueous solution of hydrophobic indolecarbazole derivative, which allows minimizing the concentration of organic solvents in the composition of DF.Materials and methods. The object of the study is the active substance LHS-1269 series 010320, produced in the Chemical Synthesis Laboratory of the N. N. Blokhin National Medical Research Center of Oncology. The following auxiliary substances were used to obtain model compositions: Kollidon® 17 PF, Kollisolv® PEG-400, Kolliphor® P 188, Montanox™ 20, DMSO (p.a.), ethanol 95 % (standardized according to pharmacopoeia quality standard ФС.2.2.0019.18 of The State Pharmacopoeia of the Russian Federation). Analytical scales OHAUS Analytical Plus AP 100S and laboratory scales AND DL-120 were used for weighing LHS-1269 and auxiliary substances. The dissolution and mixing of the components was carried out on an IKA® C-MAG HS 4 magnetic stirrer.Results and discussion. In the course of the study, 2 groups of model compositions were obtained and estimated, comprising a complex of two or more auxiliary substances as a solubilizer. The first group of formulations contained DMSO at a concentration of 5 % and ethanol at concentrations from 0 to 15 %. The compositions of the second group included DMSO from 0 to 4 %. As a result, it was found that the addition of 5 % Kolliphor® P 188 to the composition of the solution reduces the content of ethanol to 5 %. In this case, with further decrease in ethanol, turbidity of the solution and precipitation are observed. Reducing the concentration of DMSO in the DF to 2 % was achieved by using a combination of 20 % ethanol and solubilizer complex – Kollidon® 17 (20 %), Kollisolv® PEG-400 (20 %) and Kolliphor® P 188 (5 %). In this case, the total dissolution of the active substance without DMSO was observed when compensating for the organic solvent by introducing additional auxiliary substances – Montanox™ 20 (5 %) and benzene (2 %).Conclusion. As a result of the research, the compositions of the auxiliary substances of solubilizers are selected, allowing to obtain an aqueous solution of the hydrophobic compound LHS-1269 with a minimum concentration of organic solvents.