bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of maternal pre-pregnancy body mass index with macrosomia: a birth cohort study from China
Authors: Yan Mingxin , Zhang Yunbo , Zhao Doudou , Zhao Yan , Liu Danmeng , Shan Li , Mi Yang , Pei Leilei , Qu Pengfei 
Published: September 2023

Abstract

To investigate the association between pre-pregnancy body mass index (BMI) and the risk of macrosomia through a preconception-early pregnancy-birth cohort in China. From July 2018 to December 2021, we recruited a total of 12,254 women of childbearing age from the Northwest Women's and Children's Hospital of China. We collected basic demographic characteristics and lifestyle behavior information of the subjects through questionnaires and practical measurements, and conducted further follow-up for pregnancy outcomes. The study assessed the association of pre-pregnancy BMI with macrosomia using logistic regression models, and performed a linear trend test. Moreover, we utilized restricted cubic splines and polynomial regression to investigate the non-linear relationship of pre-pregnancy BMI with macrosomia. A total of 11438 subjects were included in this study and the prevalence of macrosomia among all infants was 5.64 per cent. The results indicated that, when compared to the normal weight group, the risk of macrosomia was higher in the overweight and obesity groups (overweight: (OR=1.66 (1.35-2.01)); obesity: (OR=1.66 (1.13-2.45))), and the risk of macrosomia was lower in the underweight group (OR=0.55 (0.41-0.73)). Additionally, similar findings were observed concerning the relationship between pre-pregnancy BMI and grade 1 macrosomia. The use of restricted cubic splines revealed that the prevalence of macrosomia/grade 1 macrosomia increased with rising pre-pregnancy BMI. Furthermore, when we stratified the data by covariates, the nonlinear relationship between pre-pregnancy BMI and macrosomia/grade 1 macrosomia persisted. The results of the polynomial regression showed a gradual increase in fetal birth weight with increasing pre-pregnancy BMI levels. Pre-pregnancy overweight and obesity were associated with higher risks of macrosomia. Therefore, it indicates that it may be possible to decrease the risk of macrosomia through preconception weight regulation.
Analyzing Tattoo Pigments in a Laboratory Setting: Application of UV-Vis and FTIR Spectroscopy Methods supported with Chemometric Modelling
Authors: Singh Ajay Vikram , Bansod Girija , Schumann Angelina , Bierkandt Frank S. , Laux Peter , Nakhale Sweta Vijay , Shelar Amruta , Patil Rajendra , Luch Andreas 
Published: September 2023

Abstract

Physicochemical characterization of tattoo inks has a major impact on their safe usage in tattoo art. Analytical measurements of pigments used in tattoo inks is a real challenge when monitoring their quality. UV-Vis (ultraviolet visible) and Fourier-transform infrared (FTIR) spectroscopy with chemometrics could be used to predict pigment contents in tattoo inks. This study sought to determine the pigments red (PR) 170/254 and pigment blue (PB) 15:3 content, purchased from different suppliers, to examine the different chemical structures and existing impurities of the samples. In this study, UV-Vis and FTIR spectra were collected, and regression models were used to analyze the data. There were significant correlations across both spectrum areas, with coefficients of determination for cross validation greater than 0.7 for most parameters. The two spectroscopic methods come to almost identical results with regard to pigment identity. UV-Vis spectroscopy was found to be suitable method for analyzing changes in pigment concentration and structural evolution. Chemometric modeling showed improved predictions of FTIR parameters, especially in the functional group and fingerprint region of the spectra. The results highlight the significance of utilizing UV-Vis/IR wavelengths to determine pigment structures in samples from various suppliers.
Neutrophilic activity biomarkers (plasma neutrophil extracellular traps and calprotectin) in established rheumatoid arthritis patients receiving biological or JAK inhibitors: a clinical and ultrasonographic study
Authors: Frade-Sosa Beatriz , Ponce Andrés , Ruiz-Ortiz Estíbaliz , de-Moner Noemí , Gómara María J. , Azuaga Ana Belén , Sarmiento-Monroy Juan C , Morlà Rosa , Ruiz-Esq Virginia , Macías Laura , Sapena Nuria , Tobalina Lola , Ramirez Julio , Cañete Juan D , Yague Jordi , Auge Josep M , Gómez-Puerta Jose A , Viñas Odette , Haro Isabel , Sanmartí Raimon 
Published: September 2023

Abstract

Background: Research into blood biomarkers of disease activity in rheumatoid arthritis (RA) has grown significantly. Accumulating evidence suggests that neutrophils play a crucial role in the initiation and progression of RA. This study assesses the accuracy of neutrophil activation markers, including neutrophil extracellular traps (NETs) and calprotectin, as biomarkers of disease activity in patients with established RA. We also analyse the relationship between NETs and various types of therapies as well as their association with autoimmunity.
Methods: We performed an observational cross-sectional study of RA patients receiving treatment with biological disease-modifying antirheumatic drugs (DMARDs) or JAK inhibitors for at least 3 months. Plasma calprotectin levels were measured using an enzyme-linked immunosorbent assay (ELISA) test kit. NETs were assessed by measuring their remnants in plasma, including neutrophil elastase–DNA (NE-DNA) and histone–DNA (H3-DNA) complexes. We also assessed clinical disease activity, joint ultrasound (US) findings and autoantibody status (rheumatoid factor (RF), anti-citrullinated peptide/protein antibodies (ACPAs) and anti-carbamylated protein (anti-CarP) antibodies). Associations between neutrophilic biomarkers and clinical or US scores were sought using correlation analysis. The discriminatory capacity of both neutrophilic biomarkers to detect US synovitis was analysed through ROC curves.
Results: Plasma NET levels did not correlate with clinical disease status, regardless of the clinic index analysed or the specific biological therapy administered. Moreover, no significant correlation was observed between NET remnants and US-detected synovitis. Additionally, there was no correlation between plasma NET levels and autoantibodies (RF, ACPAs, anti-CarP). In contrast, plasma calprotectin positively correlated with clinical parameters (SJC rho=0.49, CDAI rho=0.30; p<0.001) and US parameters (rho>0.50; p<0.001). Notably, this correlation was stronger than that observed with acute phase reactants (high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR)).
Conclusion: While NETs formation induced by neutrophils may play a role in RA pathogenesis, our study raises questions about the utility of NET remnants in peripheral circulation as a biomarker for inflammatory activity. In contrast, this study strongly supports the usefulness of blood calprotectin as a biomarker of inflammatory activity and local synovitis in patients with RA, consistent with previous findings.
Soil contamination around porphyry copper mines; an example from a semi-arid climate
Authors: Alizadeh Arezu , Ghorbani Jamshid , Motamedi Javad , Vahabzadeh Ghorban , Ent Antony , Edraki Mansour 
Published: September 2023

Abstract

Extraction and processing of metalliferous ores can cause severe disturbances and contamination in natural ecosystems but little known about such effects for copper mines in semi-arid areas of southwest Asia. This study was conducted on seven sites around Sungun Copper Mine area, northwest Iran. Electrical Conductivity (EC), pH, nitrogen, phosphorous, potassium, organic matter, soil texture along with 16 metal and metalloids concentrations were measured in 94 soil samples. Results showed that sites were distributed along a gradient of contamination from low contamination in natural hillsides to high contamination in Waste Rock Dump, Oxide Dump, alongside Pakhir and Sungun Rivers. Nutrient (N, K, Ca, Mg) deficiency occurred in disturbed sites. The main contaminant sources were Waste Rock Dump, mine pit drainage, and Oxide Dump. The results of Non-metric multidimensional scaling ordination showed elevated Cd, Zn, Fe, Cu, Pb, As, Mo, Mn, Co, S concentrations, high EC, and higher sand percentage in the sites affected by mine waste and acid mine drainage. Geo-Accumulation and Potential Ecological Risk Indices indicate that Pakhir riverside, Sungun riverside and Oxide Dump have severe to moderate levels of environmental risks. Positive correlations between some metal elements imply their common sources and similar reaction pathways could also be a reason for their similar geochemical behaviour in transport and deposition and their interdependence. Overall, the deficiency of organic matter nutrients along with the soil sandy texture in contaminated sites of Sungun Copper Mine are the main limiting factors in managing metal mobility and soil remediation.
Cleft lip and palate severity and COVID-19 related risk factors in five Arab Countries
Authors: Sabbagh Heba Jafar , Zeinalddin Mohammad , Al-Batayneh Ola B. , Bulushi Taimoor Al , AboulHassan Mamdouh A. , Koraitim Mohamed , Alkharafi Lateefa , Almuqbali Buthaina , Alghamdi Sultan Musaad , Bahdila Dania , Refahee Shaimaa Mohsen , Quritum Maryam , Taqi Fatemah Fahad , Albassam Bader , Ayed Mariam , Embaireeg Alia , Alnahdi Raqiya , AlSharif Mona Talal , Aljohar Aziza Johar , Abdulhameed Fatma Dawood , Alrejaye Najla Sulaiman , Viswapurna P S , Halasa Tamara Al , Tantawi Maha El , Basri Osama Adel , Alamoudi Rana A. 
Published: September 2023

Abstract

Background: Little is known about factors associated with the severity of cleft lip with or without cleft palate (CL/P) especially during COVID-19 pandemic with its dramatic changes.
Objectives: The aim of this multi-national study is to measure the association between CL/P severity, COVID-19 infection, and fear of COVID-19 in Five-Arab countries.
Methods: This cross-sectional study took place in major governmental hospitals in Five-Arab countries from November-2020 to April-2023. Participants were infants born with CL/P and their mothers who were in their 1sttrimester during the COVID-19 pandemic. Clinical examination was carried out and CL/P cases were grouped according to phenotype (cleft lip and palate (CLP) versus cleft lip (CL)), cleft extension (incomplete versus complete) and site (unilateral versus bilateral) to assess severity. Information on maternal COVID-19 infection and fear of COVID-19 were gathered.
Results: The study recruited 274 CL/P infants. Maternal COVID-19 infection during pregestation and 1st trimester was significantly associated with higher odds of CL/P severity (AOR=2.707; P=0.002) than mothers without COVID-19 infection. Using supplements during pregnancy showed protective effect (AOR=0.573; P=0.065).
Conclusion: Mothers infected with COVID-19 before and during pregnancy had more than two folds’ higher odds of having infant with a more severe CL/P phenotype.
The Relationship between Safety Climate and Job Satisfaction Among Employees in a Tire Manufacturing Company
Authors: Vosoughi Shahram , Shekaftik Soqrat Omari , Arbousara Fatemeh Shabani , Noushabadi Zhaleh Sedghi 
Published: September 2023

Abstract

This research aimed to investigate the influence of safety climate on job satisfaction and determine the relative importance of these variables among employees employed in a tire manufacturing organization. A descriptive-analytical cross-sectional study was conducted involving 280 individuals working in a tire manufacturing company. The data collection process involved the utilization of Dante's job satisfaction questionnaire and the NOSACQ Nordic Safety climate questionnaire. Data analysis was performed using the software SPSS version 29.0 and R programming language version 4.2.2. The findings revealed that individuals who had not experienced workplace accidents exhibited significantly higher levels of job satisfaction compared to those who had encountered such incidents. Moreover, the results of multiple regression analysis demonstrated a significant relationship between job satisfaction and factors including overall safety climate score, history of workplace accidents, and educational status. These findings undeniably underscore the crucial role of safety climate in influencing employees' job satisfaction levels within the tire manufacturing industry.
Hyperglycemia with hypogonadism and growth hormone deficiency in a 17-year-old male with H Syndrome: The first case report from Syria
Authors: Hamsho Suaad , Alaswad Mohammed , Sleiay Mouhammed , ALHUSSEINI AYHAM 
Published: September 2023

Abstract
Background: The nucleoside transport capabilities of the human equilibrative nucleoside transporter-3 (hENT3) are disrupted by mutations in SLC29A3 (10q22.2), which are genes for the nucleoside transporter and are the cause of the unusual autosomal recessive disease known as H syndrome. As a result, histiocytic cells invade a number of organs.
Case presentation: A 17-year-old Syrian male was admitted to the internal medicine department with a one-month history of polyuria, polydipsia, general weakness, and pallor. He had a history of progressive bilateral sensorineural hearing loss and failure to gain weight for three years. Physical examination revealed various abnormalities, including scrotal mass, small penis and testicles, absence of pubic and axillary hair, joint abnormalities, short stature, hallux valgus, fibrous protrusion near the navel, and hyperpigmented non-itchy painful skin plaques. Clinical signs along with laboratory test results confirmed type 1 diabetes mellitus, primary hypogonadism, osteopenia, and growth hormone deficiency. After a review of the relevant medical literature, this patient’s presentation of hyperglycemia with hypogonadism, hyperpigmentation, hallux valgus, hearing loss, hematological abnormalities, and low height suggested the diagnosis of H syndrome. The patient received treatment with insulin and testosterone, leading to a significant improvement in his presenting symptoms.
Conclusions: H syndrome is a very rare illness, and the fact that the first case has only recently been reported in Syria only serves to emphasize how rare it is. H Syndrome should be suspected if a person has short stature and signs of hyperglycemia. We are reporting this instance to increase public knowledge of this exceedingly rare and unique syndrome.
Tracking Multiple Episodes of Carlin-Type Gold Mineralization Using Zircon Fission-Track Thermochronology
Authors: Shan Jiangtao , Pi Qiaohui , Luo Xianrong , Li Wei , Pailong Luo 
Published: September 2023

Abstract

The mineralization ages of Carlin-type gold deposits in the Golden Triangle area of Southwest (SW) China have not been adequately defined. We applied zircon fission-track (ZFT) analysis to determine the mineralization ages. The age groups were divided into three periods by ZFT dating and a decomposition method: 230–200, 180–150, and 130 Ma, corresponding to the three magmatic–mineralization episodes in SW China. ZFT analysis was employed to effectively track the multiepisode mineralization history of the Carlin-type gold deposits. Based on the results from this study and existing studies, the Carlin-type gold deposits were probably formed predominantly during 230–200 Ma and were overprintedby the Yanshanian mineralization episodes.
Harnessing Striga-Tolerant Varieties and Enhanced Crop Nutrition: Synergistic Strategies for Managing Striga hermonthica in Maize.
Authors: AMENYOGBE MAWULI KORSI , Alhassan Abdul Mugis 
Published: September 2023

Abstract

Background and aims
In Ghana, maize production is currently faced with low yields due to the infestation of Striga hermonthica. As a result, this study was conducted to examine the combined effect of Striga-tolerant maize varieties and integrated nutrient management (INM) on Striga control and host performance.
Methods
The experiment was a factorial design laid out in a Randomized Complete Block in triplicate. In a Striga-infested field, the maize varieties (Wang-dataa and Omankwa) were evaluated under three levels of poultry manure (0, 5, and 10 t ha− 1) and four levels of ammonium sulfate (0, 30, 60, and 120 kg ha− 1).
Results
The ANOVA revealed that the interaction effect between the soil amendments and maize varieties significantly (p < 0.001) influenced the emergence of Striga plants and the productivity of the maize varieties. The Wang-dataa variety exhibited higher tolerance than the Omankwa variety under 10 t ha− 1 PM + 120 kg ha− 1 AS. Across the range of PM and AS applications, the highest growth and yield outputs were obtained by Wang-dataa with the application of 10 t ha− 1 PM + 120 kg ha− 1 AS. The percentage increase in grain yield for Wang-dataa and Omankwa varieties was 82 and 35%, respectively, over the control. Grain yield was positively correlated with plant height (r = 0.61*), leaf area index (0.53*), and cob weight (0.90***).
Conclusion
This study has established that a higher tolerance and productivity of Wang-dataa over the Omankwa variety were achieved with the highest combination rate of PM and AS under S. hermonthica infestation.
Identification of core genes and pathways in vacuum sealing drainage for the treatment of diabetic ulcers via bioinformatics and histological
Authors: Lu Yongpan , Cao Guoqi , Zhao Dejie , Yin Siyuan , Liu Chunyan , Song Ru , Ma Jiaxu , Sun Rui , Wu Zhenjie , Liu Jian , Wu Peng , Wang Yibing 
Published: September 2023

Abstract
Diabetic ulcers are one of the common complications of diabetes mellitus and the foot is the main site of diabetic ulcers, which involves small and medium-sized arteries, peripheral nerves, microcirculation, etc., with a high rate of disability and high treatment costs. Multidisciplinary treatments spanning medicine and material science have been applied for diabetic foot, but the molecular mechanisms are unclear. Bioinformatics was used to evaluate the differentially expressed genes when the vacuum sealing drainage (VSD) technique was used for the treatment of diabetic foot, and histological studies were performed on tissues from six clinical diabetic foot patients before and after treatment with VSD. Interleukin-6 (IL6) and prostaglandin endoperoxide synthase 2 (PTGS2) were decreased and Epidermal Growth Factor Receptor (EGFR) was increased in patients with diabetic ulcers after VSD treatment. Notably, PTGS2 likely facilitates the healing of diabetic foot ulcers by controlling ferroptosis and may be both a significant prognostic marker and a potential therapeutic target.
Acute thyroid hormone exposure in children: A national retrospective study using health data routinely collected by the French Poison Control Centers
Authors: PARADIS Camille , COURTOIS Arnaud , VAUCEL Jules-Antoine , BLANC-BRISSET Ingrid , RECORD Cécile , GRENET Guillaume , GOMES Elisabete , NARDON Audrey , LABADIE Magali 
Published: September 2023

Abstract
Purpose: Thyroid hormones are involved in many metabolic and physiological processes, including basal metabolism, thermoregulation, and heart rate. However, there is little information on acute exposure in children, with only a few cases reports or small cases series being available. Our study was undertaken to provide more information about the epidemiological and clinical course of l-thyroxine poisoning in a large pediatric population.
Study design: This multicenter historical cohort study was conducted using data from the French Poison Control Centers on the acute ingestion of thyroid hormone in children (0–12 years of age) between 1 January 2018 and 31 December 2020.
Results: Of the 2,321 files analyzed, 1,248 cases were included. Preschool children aged 2–5 years old accounted for 79.4% of the cases. Oral ingestion was unintentional in 98% of the cases. The medicine was from a relative in 97.5% of cases. Only 10 (0.8%) children were symptomatic. No symptoms were reported below a dose of 6.6 µg/kg and some patients remained asymptomatic up to an assumed dose of 500 µg/kg. The symptoms reported were minor, transitory, and limited to tremor, agitation, diarrhea, vomiting, and tachycardia. Comparing the assumed intake doses between unintentional and intentional exposure, and between asymptomatic and symptomatic cases, there were no significant differences (p > 0.05).
Conclusion: Acute l-thyroxine poisoning in children was mainly accidental (unintentional) and has only a few benign symptoms. The clinical outcome is good even if the assumed ingested dose is massive (up to 500 µg/kg).
A universal perovskite/C60 interface modification via atomic layer deposited aluminum oxide for perovskite solar cells and perovskite-silicon tandems
Authors: Wolff Christian , Artuk Kerem , Turkay Deniz , Mensi Mounir , Steele Julian , Jacobs Daniel , Othman Mostafa , Chin Xin Yu , Moon Soo-Jin , Tiwari Ayodhya , Hessler-Wyser Aïcha , Jeangoros Quentin , Ballif Christophe 
Published: September 2023

Abstract
The primary performance limitation in inverted perovskite-based solar cells is the interface between the fullerene-based electron transport layers and the perovskite. We developed atomic layer deposited thin AlOX interlayers that reduce nonradiative recombination at the perovskite/C60 interface, resulting in > 60 millivolts improvement in open-circuit voltage and 1% absolute improvement in power conversion efficiency. Surface-sensitive characterizations indicate the presence of a thin, conformally deposited AlOx layer, functioning as a passivating contact. These interlayers work universally using different lead-halide-based absorbers with different compositions where the 1.55 electron volts bandgap single junction devices reach >23% power conversion efficiency. We find a reduction of metallic Pb0 and the compact layer prevents in- & egress of volatile species, synergistically improving the stability. AlOX-modified wide-bandgap perovskite absorbers as a top cell in a monolithic perovskite-silicon tandem enable a certified power conversion efficiency of 29.9% and open-circuit voltages above 1.92 volts for 1.17 square centimeters device area.
Urbanization will drive changes in the African food system and biodiversity through dietary shifts rather than through urban expansion
Authors: De Vos Koen , Janssens Charlotte , Jacobs Liesbet , Campforts Benjamin , Boere Esther , Kozicka Marta , Leclère David , Havlík Petr , Hemerijckx Lisa-Marie , Rompaey Anton Van , Maertens Miet , Govers Gerard 
Published: September 2023

Abstract

The rapid urbanization in Africa profoundly affects local food and ecological systems. According to earlier research, urbanization may cause food production and biodiversity losses as agricultural or natural lands are absorbed by expanding cities. Although land use displacement effects may potentially buffer agricultural production losses or lead to additional biodiversity losses, they are often overlooked. Moreover, effects of urbanization-induced dietary changes are rarely considered. To address this, we combined spatially-explicit projections of African urban expansion and observed urbanization-induced rice consumption shifts in a partial equilibrium model (GLOBIOM). We highlight the importance of displacement effects to identify potential food production or biodiversity issues accurately and argue for their integration in land-use planning and policymaking across spatial scales. We also show that accounting for urbanization-induced dietary shifts for rice increases estimated values in rice production, trade, and agricultural methane emissions and thereby underscore the need for granularity in future food demand predictions.