bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of social burden and underage children in neuro-oncological patients
Authors: Kamp Marcel A. , Sass Christiane , Januzi Donjetë , Dibué Maxine , Libourius Katharina , McLean Anna Lawson , Baumgarten Peter , McLean Aaron Lawson , Dinc Nazife , Senft Christian 
Published: July 2023

Abstract
Objective
Brain tumours can cause significant burden for patients and their families, including physical, psychological, and social challenges. This burden can be particularly difficult for patients with malignant brain tumours and those with underage children. However, the frequency of social burden among neuro-oncological patients and the proportion of patients with underaged children is currently unknown. The aim of this retrospective study is to determine the frequency of social and family dysfunction among neuro-oncological patients, the percentage of such patients who have underage children, and to assess their associated burden.
Methods
During a 22-month period, all outpatient brain tumour patients were asked to complete a short questionnaire that included epidemiological data, the EORTC-qlq-C30 and -BN20 questionnaire, and the distress thermometer. Data were collected and analysed using Prism 9 for macOS (Version 9, GraphPad Prism).
Results
Our analysis included 881 brain tumour patients, of which 540 were female. Median age was 61 years (ranging from 16 – 88 years). Of all patients, 228 suffered from malignant intracranial tumours. More than half of all patients and more than 65 % of patients with malignant tumours reported that their illness or medical treatment interfered with their social activities and family life. Almost 30 % of patients reported moderate or severe complaints. About 27 % of all patients (and 31 % of patients with malignancies) expressed moderate or major concerns that their family life could be disrupted.
Among the patients with malignancies, 83.5 % of patients had a total of 318 children at the time of tumour diagnosis, with a mean age of 33 ± 0.9. Of these patients with malignancies, 38 (17.9 %) had a total of 56 underage children at the time of tumour diagnosis, and currently have 53 underage children. Patients with minor children had more financial worries but less interference of their disease with social activities, less psycho-oncological distress, and a more positive outlook into the future (each, p < 0.0001). They evaluated their general health status and quality of life in the week prior to their current appointment significantly better (each p < 0.0001).
Conclusion
Our study found that 17.9 % of patients with malignant brain tumours have underage children. However, having underage children may actually be a positive resource for these patients, as they show lower distress values and better quality of life.
Systemic immune-inflammation index predicted clinical outcome in patients with aortic stenosis
Authors: Tang Yiyang , Zha Lihuang , Liu Zhenghui , Chen Qin , Feng Yilu , Juaiti Mukamengjiang , Zeng Xiaofang , Sun Jing , Yu Zaixin , Liang Benhui 
Published: July 2023

AbstractBackground Systemic immune-inflammation index (SII) is a novel inflammatory-related biomarker, and we aim to explore whether it can predict the poor prognosis of patients with aortic stenosis (AS). Methods The detailed data of patients with AS were extracted from the MIMIC-IV database. Restricted cubic spline (RCS) and COX regression analyses were used to reveal the potential association between SII and all-cause mortalities. Propensity score matching (PSM), inverse probability of treatment weighting (IPTW), and subgroup analyses were conducted to validate our findings. Receiver operating characteristic (ROC) analysis was performed to assess the performance of SII prognostic model. Results 839 patients were included in the study cohort. RCS analysis elucidated that the death risk of patients was gradually elevated with the increase of SII. Multivariate-adjusted 30-day (HR: 2.130; 95% CI: 1.167–3.885), 90-day (HR:1.644; 95% CI: 1.059–2.552) and 1-year (HR: 1.634; 95% CI: 1.136–2.350) all-cause mortalities were significantly higher in patients with high SII, which remained robust after PSM, IPTW, and subgroup analyses. The area under the ROC curve of SII (AUC: 0.727; 95% CI: 0.683–0.771) was superior to that of SOFA (AUC: 0.577; 95% CI: 0.525–0.629) and SAPSII (AUC: 0.681; 95% CI: 0.638–0.724) scores. Conclusion For patients with AS, SII was an independent predictor of elevated short-and long-term all-cause mortalities, with good predictive capability.
Poor periodontal health is linked to impaired cognitive performance in older people: A cross-sectional study
Authors: Arenas-Márquez María Jesús , Toro Pablo , Aguayo Sebastian 
Published: July 2023

Abstract

Background At present, there is no cure for dementia, and most available treatments have shown marginal or no effect. This fact makes it crucial to identify factors that increase the risk of cognitive decline in the population. Evidence suggests that poor periodontal health may be one of those factors; nonetheless, to ascertain this possibility, it is necessary to account for the influence of education, as it is frequently the determining factor that explains the association between a risk factor and cognitive impairment. Therefore, this study aimed to determine whether poor periodontal health is associated with impaired cognitive performance in older people from an agricultural community in Chile, independent of education. Methods A cross-sectional study was conducted with the entire universe of participants older than 60 years from the MAUCO cohort in 2015. The exposure of interest was periodontal health status assessed through a proxy measure based on gum appearance (color) and bleeding, and individuals were categorized into three groups: healthy periodontium, signs of possible disease, and unhealthy periodontium. The dependent variable was cognitive performance evaluated using the ACE-R test. The confounding effect generated by sociodemographic factors was controlled through regression models: linear regression with the score obtained in the ACE-R test and multinomial regression for normal cognition, cognitive impairment, and dementia as outcomes. Results The study included 2,716 participants with a mean age of 65.7 ± 4 years, of whom 52% were women and 63% had a low educational level. Unhealthy periodontium was observed in 10.8% of the individuals, while 17.6% had cognitive impairment or dementia. People with an unhealthy periodontium scored two points lower on the ACE-R test and were almost twice as likely to have dementia (OR 1.86 95% CI 1.07–3.25) than those with periodontal health, regardless of age, sex, and educational level. Conclusion Older people with unhealthy periodontium seem to have worse cognitive performance and a higher possibility of suffering from dementia than those with healthy periodontium, regardless of sociodemographic factors. Education does not explain this outcome.
Brown vs Green Energy Sources and Resource Productivity: The Role of Human Capital and Technology Transfer in Developing Economies
Authors: Aladejare Samson Adeniyi , Salihu Bobbi 
Published: July 2023

Abstract
This study determined the impacts of non-renewable and renewable energy consumption on natural resource productivity alongside human capital and technology transfer roles for 40 selected developing economies. The study relied on a dataset sourced between 1991 and 2021. The study applied the novel method of moments quantile regression (MMQREG) procedure for the analyses while ensuring inferential robustness through the fully modified ordinary least squares (FMOLS), dynamic OLS (DOLS), and Driscoll-Kraay (D-K) methods. Empirically, the study revealed that an increase in brown energy consumption exhausted resource productivity from the lower to the upper quantiles. In contrast, green energy utilisation enhanced resource productivity from the lower to the higher quantiles. Also, while human capital adversely affected resource productivity for both energy means, technology transfer positively impacted it from the lower to the upper quantiles. Likewise, inferences from the DOLS, FMOLS, and D-K techniques revealed similar findings. However, despite non-renewable energy being the dominant means of energy in these developing economies, the size of its adverse impact on resource productivity falls short of the increasing effect of renewable energy across all quantiles. Also, the magnitude of the negative impact of human capital on resource productivity is marginally more substantial with non-renewable energy. In contrast, the robustness of the enhancing impact of technology transfer is slightly more with renewable energy.
JEL Classification: O47, Q2, Q32.
Identification and analysis of influencing factors on construction quality management for rural drinking water safety projects
Authors: Xu Shuitai , Chen Meiling , Zhou Yuhui , Wang Yabo 
Published: July 2023

Abstract

Exploring the influencing factors of construction quality management is the key to ensuring the quality of rural drinking water safety projects. Based on grounded theory, the influencing factors were identified and 65 relevant staff were selected by the objective sampling method for in-depth interviews to obtain the original data. In this study, 34 initial concepts, 18 main categories, and five core categories were collected and extracted for the rural drinking water project's safety engineering and construction quality management evaluation system. Furthermore, the incremental model of influencing factors on construction quality management performance of rural drinking water safety projects was established by the Decision-Making Trial and Evaluation Laboratory–Interpretive Structural Modeling (DEMATEL-ISM) model. Through calculation and analysis, the key influencing factors of construction quality management performance of rural drinking water safety projects were identified as controls on common quality problems, quality specification implementation, leadership level, acceptance management, design disclosure and modification, and human environment. Countermeasures and suggestions are proposed to improve the construction quality management performance of rural drinking water safety construction projects.
A organização textual da macroestrutura do sermão temático: um estudo funcionalista das relações retóricas
Authors: Nery Nascimento Simone Maria Barbosa 
Published: July 2023

O sermão bíblico, gênero pertencente à esfera religiosa, existe há milhares de anos, no entanto, é ainda um gênero de grande difusão e que merece ser investigado. Com o objetivo de analisar a sua organização estrutural, o presente trabalho adotou a Teoria da Estrutura Retórica (Rhetorical Structure Theory - RST) e a Perspectiva Textual-Interativa (PTI) como embasamento teórico. Como unidade de análise, adotou-se o tópico discursivo. O corpus do trabalho é constituído de um sermão temático. A análise demonstrou que existe uma organização macroestrutural ordenada conforme os princípios da retórica (basicamente: introdução, desenvolvimento e conclusão). Foram identificadas nesse nível as seguintes relações: fundo, parentética, evidência, elaboração, lista ou sequência, e conclusão. Dessa maneira, verificou-se que as relações retóricas não são essenciais apenas para a compreensão da organização microestrutural do texto, mas também se manifestam a favor da caracterização do gênero textual. Portanto, acredita-se que a articulação teórica proposta possa contribuir no tratamento também de outros gêneros que requerem um planejamento prévio e que tenham um caráter persuasivo.
Estratégias de indeterminação de sujeito nas línguas bantu: o caso da língua ronga
Authors: Dimande Ernesto Mário 
Published: July 2023

No presente artigo discutimos as estratégias de indeterminação de sujeito na língua ronga, uma língua bantu integrada no grupo Tswa-Ronga (S50), falada na Província e Cidade de Maputo. A discussão deste tema tem como objetivo identificar estratégias que os falantes desta língua adotam no processo de indeterminação de sujeito. A análise de dados recolhidos através de um questionário estruturado e administrado a 20 falantes nativos da variante dialectal Xinondrwana e analisados com base nas abordagens de Mioto, Silva e Lopes (2004), Perini (2010), Bechara (2010) e Cunha e Cintra (2011), sugere que para os falantes desta língua indeterminar o sujeito implicam a adoção de três estratégias: i. flexão do verbo na 3ª pessoa do plural; ii. uso da passiva, através dos morfemas indeterminadores ku- e -iw-; e iii. o preposicionamento de sujeito com referência genérica.
A Multimodal Approach to Analgesia in Anorectal Surgery
Authors: Garmanova T. N. , Markaryan D. R. , Kazachenko E. A. , Lukianov A. M. , Kazachenko M. A. , Agapov M. A. 
Published: July 2023

Аim: Evaluation of methods for pain prevention and pain reduction after anorectal surgery at all stages of treatment based on publications found in available databases.Key points. Most anorectal diseases are benign and do not affect life expectancy, meanwhile about 40 % of the population suffer from it. Mainly anorectal disorders affect middle-aged people reducing their life quality. At the same time many articles aimed at studying only postoperative anesthesia. 2 researchers independently searched for articles published in Medline, Scopus, Cochrane, Web of Science, E-library databases using keywords. A total of 54 publications were included. A multimodal approach should include the pain prevention during pre-, intra- and postoperative periods. Acetaminophen is recommended for pain reduction according to the dosing protocols. Acetaminophen combined with other systemic analgesics is advisable for patients with severe pain. The opioids use is justified only for moderate-severe postoperative pain. Metronidazole and lidocaine with nitroglycerin ointment/ nifedipine/сorticosteroids effectiveness has been proven for local postoperative anesthesia. Prophylactic use of antibiotics and bowel preparation do not reduce postoperative pain. Stool softeners are recommended for reducing postoperative pain severity. Additional local anesthesia such as nerve blockade or infiltration anesthesia is recommended for all patients. Modern minimally invasive treatment methods of hemorrhoid are associated with less severe postoperative pain.Conclusion. The recommended scheme of multimodal anesthesia for patients after anorectal surgery is shown on Fig.1. Further studies are needed to evaluate preoperative anesthesia effectiveness, the feasibility of the perioperative flavonoids use, as well as comparisons of various minimally invasive treatment methods of anorectal diseases.
Evaluation of Small Intestinal Permeability in Patients with Overlap Syndrome (Autoimmune Hepatitis/Primary Biliary Cholangitis)
Authors: Akberova D. R. , Odintcova A. Kh. , Abdulganieva D. I. 
Published: July 2023

Аim: to evaluate the state of small intestine permeability by the “double sugar test” in patients with overlap syndrome (autoimmune hepatitis / primary biliary cholangitis (AIH / PBC)).Materials and methods. Prospectively, 56 people were included in the study. Of these, 26 were diagnosed with AIH/PBC, 30 were in the control group. The diagnosis was made in accordance with the current recommendations. The average age of patients was 49.7 ± 13.8 years, healthy volunteers — 48.6 ± 9.2 years. The determination of the permeability of the small intestine was carried out by a “double sugar test” (the ratio of lactulose/mannitol in urine), using the method of high-performance liquid chromatography — mass spectrometry.Results. In patients with AIH/PBC, an increase in intestinal permeability was found — 0.20 [0.09; 0.30] (p < 0.001) compared with the control group 0.01 [0.01; 0.02]. We divided patients at the stage of liver damage. An increased small intestinal permeability was revealed: hepatitis stage — 0.19 [0.13; 0.30] (p < 0.001), liver cirrhosis stage — 0.18 [0.09; 0.30] (p < 0.05) compared with the control group. In the early stages of disease (1 month from the onset of the disease) had an increased lactulose/mannitol ratio — 0.13 [0.05; 0.26] (p < 0.001) compared to the control group. In the presence of portal hypertension (PH), small intestinal permeability was increased — 0.18 [0.09; 0.30] (p < 0.001) compared with the control group.Conclusions. An increase in small bowel permeability was found in patients with overlapping syndrome. All patients had increased intestinal permeability (regardless of the presence of extrahepatic manifestations).
Large Rearrangements in Genes Responsible for Familial Adenomatous Polyposis, <i>MUTYH</i>-Associated Polyposis and Peutz–Jeghers Syndrome in Russian Patients
Authors: Loginova A. N. , Shelygin Yu. A. , Shubin V. P. , Kuzminov A. M. , Pikunov D. Yu. , Saveleva T. A. , Tsukanov A. S. 
Published: July 2023

Аim: to reveal the rate of large rearrangements in the genes responsible for familial adenomatous polyposis, MUTYH-associated polyposis and Peutz–Jeghers syndrome.Materials and methods. The MLPA method was used for identification of large rearrangements. A total number of 135 patients was included in the study: 83 patients with a clinical diagnosis of “familial adenomatous polyposis”, 18 — with suspected MUTYH-associated polyposis, and 34 — with a clinical diagnosis of “Peutz–Jeghers syndrome”.Results. Seven large deletions and one large duplication in the APC gene were identified in 83 patients with classic familial adenomatous polyposis, with rate of large rearrangements 9.6 % (8/83). In 18 patients with suspected MUTYH-associated polyposis, no large rearrangements were found in the MUTYH gene. Four large deletions in the STK11 gene (12 %, 4/34) were detected in 34 patients with Peutz–Jeghers syndrome.Conclusion. For the first time, the expediency of including the method of detecting large rearrangements in routine DNA test list for Russian patients with various hereditary polyposis syndromes is demonstrated. Routine use of MLPA method makes it possible to increase the total frequency of detection of pathogenic variants in the APC and STK11 genes above 90 %. At the same time, the need for searching of large rearrangements in the MUTYH gene were not justified.
How to Make the Right Choice of Proton Pump Inhibitor for Patients with Gastroesophageal Reflux Disease?
Authors: Evsyutina Yu. V. 
Published: July 2023

Аim: to analyze the main pharmacokinetic properties of proton pump inhibitors (PPIs) and their significance in the treatment of gastroesophageal reflux disease (GERD).Key points. Pantoprazole has a high bioavailability, the absolute bioavailability of pantoprazole at a dose of 40 mg is 77 % from the first dose and does not change with repeated use. Pantoprazole shows a faster onset of action than omeprazole. Simultaneous food intake does not change the bioavailability of pantoprazole. Suppression of hydrochloric acid production while taking pantoprazole accompanies by the achievement of endoscopic remission of GERD by day 28 in 91 % of patients with reflux esophagitis and by day 56 in all patients in the PANSTAR studies. Pantoprazole has little effect on CYP2C19 compared to other PPIs, minimizing the risk of drug-drug interactions. Pantoprazole is the most pH-selective PPI, which determines the specificity of action only in the parietal cells of the stomach and the greatest safety of long-term use in patients with comorbid pathology.Conclusion. PPIs form the basis of the therapy of acid-dependent diseases, and, in particular, gastroesophageal reflux disease. Pantoprazole is distinguished from other PPIs by its persistent high bioavailability, long-term antisecretory effect, and very low affinity for cytochrome P450.
Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C
Authors: Ivashkin V. T. , Chulanov V. P. , Mamonova N. A. , Maevskaya M. V. , Zharkova M. S. , Tikhonov I. N. , Bogomolov P. O. , Volchkova E. V. , Dmitriev A. S. , Znojko O. O. , Klimova E. A. , Kozlov K. V. , Kravchenko I. E. , Malinnikova E. Yu. , Maslennikov R. V. , Mikhailov M. I. , Novak K. E. , Nikitin I. G. , Syutkin V. E. , Esaulenko E. V. , Sheptulin A. A. , Shirokova E. N. , Yushchuk N. D. 
Published: July 2023

Аim:diagnosis and treatment algorithms in the clinical recommendations intended for general practitioners, gastroenterologists, infectious disease specialists, hepatologists on the of chronic hepatitis C are presented.Summary.Chronic viral hepatitis C is a socially significant infection, the incidence of which in the Russian Federation remains significantly high. Over the past 10 years, great progress has been made in the treatment of hepatitis C — direct acting antiviral drugs have appeared. The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. Interferons are excluded from the recommendations due to their low effectiveness and a wide range of adverse events. The indications for the treatment have been expanded, namely, the fact of confirmation of viral replication. The terms of dispensary observation of patients without cirrhosis of the liver have been reduced (up to 12 weeks after the end of therapy). Also, these recommendations present approaches to active screening of hepatitis in risk groups, preventive and rehabilitation measures after the end of treatment.Conclusion.Great success has been achieved in the treatment of chronic hepatitis C. In most cases, eradication of viral HCV infection is a real task even in patients at the stage of cirrhosis of the liver, with impaired renal function, HIV co-infection, after solid organs transplantation.