bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic mapping and identification of Rht8-B1 that regulates plant height in wheat
Authors: Zhou Chunyun , Xiong Hongchun , Fu Meiyu , Guo Huijun , Zhao Linshu , Xie Yongdun , Gu Jiayu , Zhao Shirong , Ding Yuping , Li Yuting , Li Xuejun , Liu Luxiang 
Published: March 2023

Abstract
Background
Plant Height (PH) and Spike Compactness (SC) are important agronomic traits that affect yield improvement in wheat crops. The identification of the loci or genes responsible for these traits is thus of great importance for marker-assisted selection in wheat breeding.
Results
In this study, we used a RIL population with 139 lines derived from crossing between the mutant Rht8-2 and the local wheat variety NongDa5181 (ND5181) to construct a high-density genetic linkage map by applying the Wheat 40K Panel. We identified 7 stable QTLs for PH (3) and SC (4) under two environments using the RIL population, and found that Rht8-B1 is the causal gene of qPH2B.1 by further genetic mapping, gene cloning and gene editing analyses. Our results further showed that two natural variants from GC to TT in the coding region of Rht8-B1 resulted in an amino acid change from G (ND5181) to V (Rht8-2) at the 175th position, reducing PH by 3.6%~6.2% in the RIL population. Moreover, gene editing analysis suggested that the height of T2 generation in Rht8-B1 edited plants was reduced by 5.6%, and that the impact of Rht8-B1 on PH was significantly lower than Rht8-D1. Additionally, distribution analysis of Rht8-B1 in various wheat resources suggested that Rht8-B1b have not been widely utilized in modern wheat breeding
Conclusions
The combination of Rht8-B1b with other favorable Rht genes might be an alternative approach for developing lodging-resistant crops. Our study brings important information for marker-assisted selection in wheat breeding.
Developing a Turbulence-Inspired Zonal Combustion Modeling Approach, Implementing the CRNs in Turbulent Diffusion Flames
Authors: Modarres MohammadReza 
Published: March 2023

Abstract
Computational modeling of the combustion systems not only depends on the flow field typology but also requires well considering the turbulence-reaction interactions. Complex combustion chambers can increase numerical costs dramatically. This paper addresses a novel CFD-based chemical reactor network (CFD-CRN) integrated approach to predict combustion byproducts with high accuracy. This methodology uses turbulence intensity as a determining factor to generate clusters of reactors. The CFD simulations were performed with fine grids using the GRI-Mech 2.11 methane-air combustion mechanism with 277 elementary reactions of 49 species. The GRI-Mech 3.0 including NO formation and reburn chemistry, with 53 species and 325 reactions, is used for the CRN analysis. Implementing the CFD-based CRN, the authors found that the rate of production of NOx from the prompt, thermal, and N2O pathways are calculated as 47.37%, 22.18%, 30.45%, and 40.24%, 29.13%, and 30.63% for the Sandia flames D and E, respectively. The computational fluid dynamics reports for those pathways are predicted as 50.39%, 19.78%, 29.83%, and about 43.58%, 28.45%, and 27.97% entire the Sandia flames D and E, in order. It is deduced that the application of the hybrid CFD-CRN in combustion systems is not only reliable for its high accuracy but also is noticeably efficient for fewer CPU requirements and numerical costs, especially in industrial combustion systems.
Moisture control of tropical cyclones in high-resolution simulations of paleoclimate and future climate
Authors: Raavi Pavan Harika , Chu Jung-Eun , Timmermann Axel , Lee Sun-Seon , Walsh Kevin 
Published: March 2023

Abstract
The intensity of tropical cyclones (TCs) is expected to increase in response to greenhouse warming. However, how future climate change will affect TC frequencies and tracks is still under debate. To further elucidate the underlying sensitivities, we study TCs response to different past and future climate forcings. Using a high-resolution TC-resolving global Earth system model with 1/4o atmosphere and 1/10o ocean resolution we conducted a series of paleo-snapshot and future greenhouse warming simulations targeting the last interglacial (Marine Isotope Stage (MIS) 5e, 125 ka), glacial sub-stage MIS5d (115 ka), present-day (PD), and CO2 doubling (2×CO2) conditions. Our analysis reveals that precessional forcing creates an interhemispheric difference in simulated TC densities, whereas future CO2 forcing impacts both hemispheres in the same direction. In both cases, we find that TC genesis frequency, density, and intensity are primarily controlled by changes in tropospheric thermal and moisture structure, with warmer hemispheres exhibiting a reduction in TC density.
Teaser
Precessional and CO2 effects on tropical cyclone formation are primarily controlled by moisture-related processes.
Chemoembolization Combined Radiofrequency Ablation vs. Chemoembolization Alone for Treatment of beyond the Milan Criteria viable Hepatocellular Carcinoma (CERFA): Study protocol for a randomized controlled trial
Authors: Lee Soon Kyu , Yang Hyun , Kwon Jung Hyun , Shim Dong Jae , Kim Doyoung , Nam Soon Woo , Yoo Sun Hong , Bae Si Hyun , Lee Ahlim , Lee Young Joon , Jeon Changho , Jang Jeong Won , Sung Pil Soo , Chun Ho Jong , Kim Su Ho , Choi Joon-Il , Oh Jung Suk , Yang Yun-Jung 
Published: March 2023

Abstract
• Background

Many previous studies evaluated a combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) for treating early hepatocellular carcinoma (HCC); however, studies evaluating combination therapy for beyond-the-Milan criteria HCC are scarce.

• Methods

A total of 120 patients with beyond-the-Milan criteria HCC who have viable tumour after first TACE will be enrolled in this multi-institutional, parallel, pragmatic, randomized controlled trial. Patients with metastasis, vascular invasion, or a sum of tumour diameter > 8 cm will be excluded. Eligible patients will be randomly assigned to combination TACE and RFA therapy or TACE monotherapy groups. Patients in the combination therapy group will receive a second TACE and subsequent RFA at the viable tumour. Patients in the TACE monotherapy group will receive only second TACE. Patients in both groups will undergo magnetic resonance imaging 4–6 weeks after second TACE. The primary endpoint is 1-month tumour response, and secondary endpoints are progression-free survival, overall response rate, number of treatments until CR, overall survival, and change in liver function.

• Discussion

Although TACE can be used to treat intermediate-stage HCC, it is difficult to achieve CR by first TACE in most intermediate-stage patients. Recent studies show a survival advantage of combination therapy over monotherapy. However, most studies evaluating combination therapy included patients with a single tumour sized < 5 cm, and no studies included patients with intermediate-stage but more advanced (i.e., beyond-the-Milan criteria) HCC. This study will evaluate the efficacy of combined TACE and RFA therapy for patients with advanced HCC within the intermediate stage.

Trial registration:

Clinical Research Information Service (CRiS) KCT0006483
Hoarseness as the first symptom in a patient with acute suppurative thyroiditis secondary to a pyriform sinus fistula: A case report
Authors: Otsuki Toshifumi , Onuma Ryoichi , Tonsho Kohei , Saito Dai , Sakai Hideyuki , Kamimura Miki , Watanabe Yohei , Kurihara Noriko , Ishida Eiichi , Kumaki Satoru 
Published: March 2023

Abstract
Background

Pyriform sinus fistulas (PSFs) are rare congenital anomalies of the third or fourth brachial clefts. Dyspnea is reportedly secondary to compression by a neck mass. However, hoarseness, as the first symptom of PSF, has not yet been reported.

Case presentation

This report describes an eleven-year-old girl presenting with hoarseness as the first symptom of PSF. Hoarseness occurred 2 days prior to admission. On admission, she had fever, hoarseness, and an elastic soft mass on her left anterior neck. Contrast-enhanced computed tomography of the cervical region demonstrated an abscess partially infiltrating the thyroid gland and an air pocket near the pyriform sinus. Pharyngoscopy revealed swelling of the left arytenoid region, with purulent retention. The left vocal cord was swollen but not paralyzed. Additionally, the laboratory data indicated thyrotoxicosis. Suspecting a PSF infection, parenteral treatment with cefotaxime and dexamethasone was initiated. On the following day, the hoarseness disappeared, and the fever resolved. Four weeks after onset, the thyroid hormone levels returned to the normal range, and a barium esophagogram revealed residual contrast in the left pyriform sinus, leading to a diagnosis of PSF.

Conclusion

PSF presenting with hoarseness as the first symptom in patients should be considered.
The impact of eHealth on relationships and trust in primary care: A review of reviews
Authors: Ramachandran Meena , Brinton Christopher , Wiljer David , Upshur Ross , Gray Carolyn Steele 
Published: March 2023

Abstract
Background: Given the increasing integration of digital health technologies in team-based primary care, this review aimed at understanding the impact of eHealth on patient-provider and provider-provider relationships.
Methods: A review of reviews was conducted on three databases to identify papers published in English from 2008 onwards. The impact of different types of eHealth on relationships and trust and the factors influencing the impact were thematically analyzed.
Results:A total of 79 reviews were included. Patient-provider relationships were discussed more frequently as compared to provider-provider relationships. Communication systems like telemedicine were the most discussed type of technology. eHealth was found to have both positive and negative impacts on relationships and/or trust. This impact was influenced by a range of patient-related, provider-related, technology-related, and organizational factors, such as patient sociodemographics, provider communication skills, technology design, and organizational technology implementation, respectively.
Conclusions:Recommendations are provided for effective and equitable technology selection, application, and training to optimize the impact of eHealth on relationships and trust. The review findings can inform providers’ and policymakers’ decision-making around the use of eHealth in primary care delivery to facilitate relationship-building.
The effect of fibrinoid necrosis on the clinical features and outcomes of primary IgA nephropathy
Authors: Chen Hongshan , Liu Youxia , Wei Li , Wang He , Zheng Zhenfeng , Yan Tiekun , Jia Junya , Li Dong 
Published: March 2023

Abstract
Background: To explore the clinicopathologic features and outcomes of IgAN patients who presented with fibrinoid necrosis (FN) lesions or not and the effect of immunosuppressive (IS) treatment in IgAN patients with FN lesions as well.
Methods: This was a retrospective cohort study with 720 patients diagnosed with primary IgAN from January 2010 to December 2020 in Tianjin Medical University General Hospital and having detailed baseline and follow-up characteristics. Explore the difference of clinicopathological characteristics in different group IgAN patients. Compare the survival from a composite endpoint rate in different group IgAN patients by Kaplan-Meier survival curve as well. The univariate and multivariate Cox models were used to establish the basic model for renal outcomes in patients with FN lesions.
Results:(1) A total of 233 patients (35.04%) were found FN lesions in all participants. Patients with FN lesions suffered more severe hematuria than those without. On the hand of pathological characteristic, patients with FN lesions showed higher proportions of M1, E1, C1/C2 and T1/T2 lesions compared with those without FN lesions. (2) The 1-year, 3-year, and 5-year survival of the composite endpoint were lower in the FN1 group than FN0 group. By contrast, patients showed no statistical significance on the survival of the composite kidney endpoint between patients with or without FN lesions after IS treatment. (3) After adjusting for clinicopathological variables, the presence of FN lesions was a significantly independent risk factor for composite endpoint. By using multivariate Cox regression analyses, we also found when the fraction of FN lesions exceeded 10%, the risk of progression into composite endpoint increased 3.927 times.
Conclusion: Fibrinoid necrosis of capillary loops is an independent risk factor of poor renal outcomes. More effective treatment like IS treatment should be considered for those who had FN lesions.
Lower rates of return to sport in patients with generalised joint hypermobility two years after ACL reconstruction: a prospective cohort study
Authors: Lindskog Jakob , Piussi Ramana , Simonson Rebecca , Högberg Johan , Samuelsson Kristian , Thomeé Roland , Sundemo David , Senorski Eric Hamrin 
Published: March 2023

Abstract
Background

Generalised joint hypermobility (GJH) is associated with an increased risk of suffering an anterior cruciate ligament (ACL) injury. Patients with GJH exhibit lower muscle strength and poorer scores for patient-reported outcomes after ACL reconstruction, compared with patients without GJH. The aim of this study was to examine differences in the percentages of patients who return to sport (RTS) or pre-injury level of activity (RTP), muscle function and patient-reported outcomes at the time of RTS or RTP, as well as the time of RTS or RTP in patients with GJH compared with patients without GJH in the first two years after ACL reconstruction.

Methods

This prospective study used data from a rehabilitation-specific register. A total of 1,198 patients aged between 16 and 50, who had an ACL injury treated with reconstruction, were included. Data up to two years after ACL reconstruction were used and consisted of results in isokinetic muscle function tests for knee extension and flexion and patient-reported outcomes (Knee Self-Efficacy Scale, Knee injury and Osteoarthritis Outcome Score and ACL-Return to Sport after Injury scale) at the time of RTS, as well as the time of RTP. A Beighton Score of ≥ 5/9 was used to define GJH. A Tegner Activity Scale of ≥ 6 was used to define RTS, while a Tegner equal to or above pre-injury level was used to define RTP.

Results

A smaller proportion of patients with GJH achieved RTS compared with patients without GJH (49.2% vs 57.3%). Furthermore, patients with GJH were marginally less symmetrical on the knee extension strength test, expressed as a Limb Symmetry Index, at the time of RTP compared with patients without GJH (87.3 ± 13.5 vs 91.7 ± 14.3). No further differences were found between groups regarding any muscle function tests or patient-reported outcomes.

Conclusion

A smaller proportion of patients with GJH achieved RTS compared with patients without GJH. Patients with GJH display less symmetrical knee extension strength at the time of RTP compared with patients without GJH.
Characteristics of distal radius fractures in east China-an observational cohort study of 1954 individual fractures
Authors: Luo Zhenyu , Zhu Wei , Jiang Chao , He Wei , Zuo Hua 
Published: March 2023

Abstract
OBJECTIVE: To investigate the epidemiological characteristics and changing trends of distal radius fractures during 5 years, which gains insight into the incidence of the disease in the region.
METHODS: Utilizing the medical imaging computer system (PACS), 1954 clinical records of radial radius fractures from patients treated at the affiliated hospital of Jiangsu University from January 2017 to December 2021 were collected and analyzed for age, gender, side, osteoporosis status, and incidence of the season.
RESULTS: there were a total of 1954 distal radius fractures, with 731 (37.4%) being male and 1223 (62.6%) being female (ratio 0.59:1), and the highest proportion was female. The median age was 56 years (range 1-102 years) with an average of 50.48 years, 1033 (52.7%) on the left side, 885 (45.1%) on the right side, and 36 (1.8%) on both sides, the left side being the highest. The age distribution was highest in the 61-70 year old group (23.9%, 467/1954), and the highest proportion in males was in the 11-20 year old group (23.8%, 174/731), and in females was in the 61-70 year old group (30.83%, 377/1223). In the 50 years and older group, there were 276 males and 991 females (ratio 1:3.59), with osteoporosis in 536 cases, accounting for 42.03% of the older fractures. The seasonal distribution was highest in summer and autumn (55.1%, 1076/1954).
CONCLUSION: In east China, distal radius fractures were predominantly female and left-sided, with the highest proportion in the age group of 61-70 years and in summer and autumn（rainy season）.
Preoperative fasting blood glucose combined with age-adjusted D-dimer levels as a predictive score to assess postoperative prognosis of early-stage cervical cancer patients: a retrospective cohort study
Authors: Zhu Chunyu , Zhang Li , Chen Xinyi , Jin Beibei , Ding Xiaoyin , Wei Qinru , Du Hongxiang , Wu Xirong , Zhang Yuquan , Peng Chen , Yang Xiaoqing 
Published: March 2023

Abstract
Background. There is a lack of methods to predict the prognosis of early-stage cervical cancer patients undergoing radical hysterectomy at present. In this study, a nomogram was constructed using commonly clinical data to evaluate the prognostic value.
Methods. Retrospective, double-center analysis of the biochemical parameters and clinicopathological factors was performed in 381 patients. Area under the curve (AUC) was used to evaluate the prognostic efficacy of FBG, D-dimer, age-adjusted D-dimer, and their combination in early-stage cervical cancer patients undergoing radical hysterectomy. Multivariable analysis of both progression-free survival (PFS) and overall survival (OS) was performed with Cox proportional hazards regression models.
Results. A new calculation formula for age-adjusted D-dimer was established. Kaplan-Meier survival analysis and AUC showed that FBG, D-dimer, and age-adjusted D-dimer had a good predictive ability for OS and PFS. A new score was established based on the cut-off values for FBG and age-adjusted D-dimer [5.45 mmol/L, 0.184 mg/L (fibrinogen equivalent units)]. Score2 for high FBG level (FBG≥5.45) and high age-adjusted D-dimer level [D-D(a)≥0.184], score1 for abnormalities in only one of the biochemical indices, and score0 for no abnormalities in both biochemical indices [FBG<5.45 and D-D(a)<0.184]. Multivariate Cox regression analysis showed that tumor size, deep stromal invasion, and score2 were independent prognostic factors for PFS and OS. These factors were used to build a nomogram for predicting OS in early-stage cervical cancer patients undergoing radical hysterectomy.
Conclusions. The score2 model combining FBG and age-adjusted D-dimer can effectively predict the prognosis of early-stage cervical cancer patients undergoing radical hysterectomy.
Savoring Life During The Pandemic: An online intervention to promote well-being in emerging adults
Authors: Villani Daniela , Pancini Elisa , Pesce Francesca , Scuzzarella Lucia 
Published: March 2023

Abstract
Background: Savoring, that is the ability to create and increase positive emotions, represents a promising approach to enhance subjective well-being (SWB) in emerging adults in times of the COVID-19 pandemic. This study aims to investigate the preliminary effects of a self-help e-savoring intervention on increasing savoring beliefs and strategies and SWB in emerging adult participants. It also examines the user experience and the perceived usefulness of the intervention.
Methods: Forty-nine participants were involved, and the experimental group (N = 23) completed six online exercises (two exercises per week for three weeks) while the control group (N = 26) did not follow the intervention. Both groups filled out online questionnaires before and after the intervention.
Results: A repeated measures ANOVA revealed a significant increase for the experimental group in savoring beliefs (especially toward the present and the future) and in positive emotions compared to the control group. The perspicuity, attractiveness, and efficiency of the online platform were very positively evaluated, and most participants rated the intervention as useful.
Conclusions: The results of this preliminary study are promising and indicate its potential for promoting savoring and positive emotions in emerging adults. Future research could evaluate its long-term effects and verify its results with other age groups.
Association between vascular access types and mortality in hemodialysis patients: A systematic review and meta-analysis
Authors: Peimin Gan , Huang Qingxiu , Xu Juan , ruan Shaowei , Pan Yurong , Liu Linna , Li Yanlin 
Published: March 2023

Abstract
Objective
To compare the mortality of different vascular access types in hemodialysis patients by using systematic review and meta-analysis of observational research.
Methods
Through a systematic literature search in PubMed and Embase databases, the English publications that directly compared the mortality of vascular access types in hemodialysis patients from 2000 to 2022 were determined. The outcomes of this study are based on the mortality hazard ratio (HR) of vascular access types. Moreover, using a random-effects model to calculate the pooled HR [95% CI] and I2 to show the heterogeneity among the included studies.
Results
Of the 4,802 studies screened, 19 studies involving 575,109 patients met the inclusion criteria and were included in the analysis. Meta-analyses revealed the significant difference for the adjusted HR of death among various vascular access types. The results of meta-analysis showed that the mortality of using central venous catheter (CVC) for hemodialysis patients was higher than using arteriovenous fistula (AVF) (pooled HR = 1.85; 95% CI, 1.55–2.22). Further, the mortality of patients with arteriovenous graft (AVG) was higher than patients with AVF (pooled HR = 1.24; 95% CI, 1.12–1.36), while the mortality have no statistically significant difference between CVC use and AVG use was found (pooled HR = 1.41; 95% CI, 1.31–1.52; P > 0.05).
Conclusions
The mortality of patients with CVC was higher than those with AVF for hemodialysis, while patients using AVG had higher mortality than those using AVF.
Facile preparation of black electrochromic ink using a copper oxide nanoparticle suspension
Authors: Jeong Chan Yang , Watanabe Hiroshi , Tajima Kazuki 
Published: March 2023

Abstract
Electrochromic (EC) materials for smart windows must exhibit a dark colour and block visible light (wavelength = 380–780 nm) to reduce environmental impact. Many researchers have attempted to use organic materials like polymers to produce these dark tones. However, their fabrication methods are complicated, expensive, and may even use hazardous substances; moreover, they are often not sufficiently durable, such as upon exposure to ultraviolet light. Therefore, herein we focused on using copper oxide (CuO) to develop an ecofriendly, inexpensive dark inorganic EC thin film by printing ink prepared using our nanoparticle (NP) dispersion technology. Specifically, we dispersed CuO NPs, synthesised by simply heating basic copper carbonate, in easily purified water using citric acid to adjust the pH. This research will enable the creation of EC smart windows using existing inorganic materials and methods, such as printing technology, and is the first step towards developing environment-friendly, cost-effective, and functional dark inorganic materials.