bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multinucleation resets human macrophages for specialized functions at the expense of their identity
Authors: Ahmadzadeh Kourosh , Pereira Marie , Vanoppen Margot , Bernaerts Eline , Ko Jeong‐Hun , Mitera Tania , Maksoudian Christy , Manshian Bella B , Soenen Stefaan , Rose Carlos D , Williams Graham R , Bassett J H Duncan , Matthys Patrick , Wouters Carine , Behmoaras Jacques 
Published: January 2023

AbstractMacrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign‐body giant cells (FBGCs) in reaction to exogenous material. How multinucleation per se contributes to functional specialization of mature mononuclear macrophages remains poorly understood in humans. Here, we integrate comparative transcriptomics with functional assays in purified mature mononuclear and multinucleated human osteoclasts, LGCs and FBGCs. Strikingly, in all three types of MGCs, multinucleation causes a pronounced downregulation of macrophage identity. We show enhanced lysosome‐mediated intracellular iron homeostasis promoting MGC formation. The transition from mononuclear to multinuclear state is accompanied by cell specialization specific to each polykaryon. Enhanced phagocytic and mitochondrial function associate with FBGCs and osteoclasts, respectively. Moreover, human LGCs preferentially express B7‐H3 (CD276) and can form granuloma‐like clusters in vitro, suggesting that their multinucleation potentiates T cell activation. These findings demonstrate how cell–cell fusion and multinucleation reset human macrophage identity as part of an advanced maturation step that confers MGC‐specific functionality.
New developments and future trajectories in supernumerary sex chromosome abnormalities: a summary of the 2022 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY
Authors: Gravholt Claus H , Ferlin Alberto , Gromoll Joerg , Juul Anders , Raznahan Armin , van Rijn Sophie , Rogol Alan D , Skakkebæk Anne , Tartaglia Nicole , Swaab Hanna 
Published: January 2023

The 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and 47,XYY syndrome was held in Leiden, the Netherlands, on September 12–14, 2022.
Here, we review new data presented at the workshop and discuss scientific and clinical trajectories. We focus on shortcomings in knowledge and therefore point out future areas for research.
We focus on the genetics and genomics of supernumerary sex chromosome syndromes with new data being presented. Most knowledge centre specifically on Klinefelter syndrome, where aspects on testosterone deficiency and the relation to bone, muscle and fat were discussed, as was infertility and the treatment thereof. Both trisomy X and 47,XYY syndrome are frequently affected by infertility.
Transitioning of males with Klinefelter syndrome was addressed, as this seemingly simple process in practise is often difficult.
It is now realized that neurocognitive changes are pervasive in all supernumerary sex chromosome syndromes, which were extensively discussed. New intervention projects were also described, and exciting new data concerning these were presented.
Advocacy organizations were present, describing the enormous burden carried by parents when having to explain their child’s specific syndrome to most professionals whenever in contact with health care and education systems. It was also pointed out that most countries do not have health care systems that diagnose patients with supernumerary sex chromosome syndromes, thus pinpointing a clear deficiency in the current genetic testing and care models.
At the end of the workshop, a roadmap towards the development of new international clinical care guidelines for Klinefelter syndrome was decided.
Epicurus’ Swerve and the Randomness Objection to Free Will
Authors: Keršys Matas 
Published: January 2023

Modern opponents of free will often aim to demonstrate its unviability by employing the standard argument against free will, which claims that either determinism or randomness is true, and that both options preclude free will. It is frequently assumed that Epicurus defended free will by positing the swerve as a third, uncaused type of atomic motion. This makes Epicurus vulnerable to criticism via the standard argument by seemingly committing him to randomness. This paper asks whether Epicurus can avoid the criticisms of the standard argument and seeks to show that he is not as vulnerable as first appearances indicate. A closer look at De Rerum Natura 2.251–293 reveals the important role of the independent deliberating mind in acts of free volition, while the claim that free volitions are a basic, sense-perceptible aspect of reality raises the question as to whether the swerve really was Epicurus’ main defence of free will.
What’s so Funny? Democritus ridens in Juvenal 10
Authors: Adomėnas Mantas 
Published: January 2023

The article analyzes Juvenal’s use of Democritean material in his tenth Satire. The famous juxtaposition of laughing Democritus and weeping Heraclitus (which popularized and perpetuated the image of contrasting philosop­hers) is habitually interpreted in terms of Juvenal’s poetic strategy, as indicating the shift in the tone of his satires and the change of Juvenal’s stance from the anger as the dominant emotion of his earlier satires to laughter and irony of the later ones. There is a tendency to assume that the totality of Democritean material in Juvenal 10 derives solely from Seneca. However, close reading of the concluding lines of the Satire suggests a different argumentative strategy and deeper engagement with Democritus’ thought by Juvenal. The comparison with Pseudo-Hippocratic ‘epistolary novel’ suggests Cynic diatribai as the source of the Democritean material in Juvenal 10.
Recursos digitais na promoção da saúde mental de trabalhadores: Protocolo de revisão sistemática
Authors: Jacques João Paulo Belini , Pinhatti Evelin Daiane Gabriel , Aroni Patricia , Leachi Helenize Ferreira Lima , Ribeiro Renata Perfeito 
Published: January 2023

Introdução: os agravos decorrentes das cargas psíquicas de trabalho são expressos no corpo do mesmo pela ocorrência de doenças ocupacionais, principalmente em trabalhadores da saúde, que estão diretamente ligados aos pacientes.
Objetivo: analisar as evidências científicas disponíveis na literatura, sobre o uso de recursos digitais na promoção da saúde mental de trabalhadores da saúde, os quais serão considerados neste estudo, todos aqueles que têm contato direto com pacientes.
Método: protocolo de revisão sistemática segundo o Manual Cochrane, onde utilizará o anagrama PICOS para Patient, Intervention, Comparator, Outcomes e Study design no desenvolvimento da pesquisa. Serão consultadas as plataformas: Medical Literature Analysis and Retrieval System Online, Cumulative Index to Nursing and Allied Health Literature, Literatura Latino-Americana e do Caribe em Ciências da Saúde, banco de dados produzido pela Associação Americana de Psicologia, banco de dados da Elsevier, Cochrane Central Register of Controlled Trials e a base da Clarivate Analytics.
Resultados: Serão apresentados em forma narrativa, com esquemas, tabelas e quadros.
Conclusão: o protocolo de pesquisa garante o rigor metodológico do processo de revisão. Dessa forma espera-se encontrar evidências de intervenções por meios digitais que promovam a saúde mental do trabalhador.
Algunas consideraciones liminares sobre la integración curricular de la investigación jurídica
Authors: Baltodano Mayorga Jose Daniel 
Published: January 2023

Este estudio tiene como objetivo analizar algunos aspectos epistemológicos y pedagógicos que sirvan como insumo en la construcción de un marco orientador para el desarrollo de acciones dirigidas a integrar la investigación al currículo en la carrera de Derecho. Para ello, se realiza una revisión documental, con el fin de contextualizar la investigación a la disciplina y, a partir de esto, determinar un esquema básico que comprende algunos conocimientos, habilidades y actitudes, además de sugerencias para orientar la didáctica.
Se concluye que, para aprender a investigar, es necesario primero saber relacionarse con el conocimiento, por lo que, además de incluir asignaturas sobre metodología de la investigación en la malla curricular, se debe disponer integralmente el proceso educativo hacia el desarrollo progresivo de los requerimientos necesarios para esta práctica, todo ello sobre la base de una educación problematizadora del derecho y la realidad.
Ransomware, una amenaza latente en Latinoamérica
Authors: Avila Niño Fredy Yesid 
Published: January 2023

En el presente artículo se evidencia que los ataques de ransomware en América Latina se han convertido en una de las ciber amenazas más importantes y a su vez más peligrosas para las organizaciones y usuarios en genera. Inicialmente se realizó una revisión bibliográfica y de casos relevantes ocurridos, lo que permitió recopilar información para determinar su evolución e impacto desde el año 2015. En esta fase se logró entender este concepto y sus características, posteriormente se identificaron los vectores de ataque y metodologías que utilizan los atacantes. Esto contribuyó a identificar los tipos de ransomware que han aparecido en los últimos años para así describir los métodos de infección que se utilizan por parte de los ciber criminales. Al reconocer el comportamiento de este malware y las tendencias asociadas a esta amenaza, se generan recomendaciones que permiten orientar a las organizaciones y a las personas para que eviten ser víctimas de ataques de este tipo, lo que constituye una contribución para mitigar este tipo de riesgo. El presente documento se obtiene de la investigación realizada en el desarrollo del trabajo de grado: “EVOLUCIÓN E IMPACTO DEL RANSOMWARE EN AMÉRICA LATINA DESDE EL AÑO 2015”.
Densification of nanoporous metals during nanoindentation: The role of structural and mechanical properties
Authors: Huber N. , Ryl I. , Wu Y. , Hablitzel M. , Zandersons B. , Richert C. , Lilleodden E. 
Published: January 2023

AbstractThe analysis of the densification behavior of nanoporous metals in nanoindentation is challenging in simulations and experiments. A deeper understanding of the densification behavior provides valuable information about the different deformation mechanisms in nanoindentation and compression experiments. The developed two-scale model allows for predicting the densification field for variable microstructure and elastic–plastic behavior. It could be shown that the penetration depth of the densification field is mainly controlled by the ratio of the macroscopic work hardening rate to yield stress. The shape as well as the value at characteristic isolines of densification depend mainly on the macroscopic plastic response of the nanoporous material. This could be confirmed by nanoindentation experiments, where the densification under the indenter was measured for ligament sizes from 35 to 150 nm. Although the depth of the densification field was underpredicted by the simulations, the experiments confirmed the predicted trends.
Graphical abstract
Complications of neck dissection and their management: Retrospective study
Authors: Kumari Sheetal 
Published: January 2023

Neck dissection (ND) is a surgical procedure performed in treating head and neck cancer patients with or without cervical nodal neck metastasis. The aim of neck dissection is to achieve loco-regional control thus optimizing the cancer cure rate. Various complications may potentially occur following this surgery. Previous studies done have documented the complication rate following neck dissection surgery to range between 5% to 15%. Most of the complications are inevitable and various efforts have been made to try and reduce complications by modifying the aggressive surgical procedure. The objective of this study is to report the various complications, its rate in various neck dissection procedures, their management and to seek improved patient care and outcome. : A systematic review of 73 patients who underwent neck dissection for various head and neck cancers from August 2017 to July 2020. These patients were studied for post-operative complications and their management.Out of 73 patients, Vascular injury observed in the current study was internal jugular vein (IJV) and was seen in 22.7%) cases and was repaired intraoperatively. Throracic duct injury was identified in 3(4.1%) and it was identified and ligated intraoperatively. Immediate post-operative complication being hemorrhage was seen among 2 cases, both the cases were re-opened. Marginal mandibular nerve and spinal accessory nerve injury was observed in 3 cases and they both came under the delayed type of complications.: A careful preoperative assessment, meticulous surgical technique, high quality postoperative care and appropriate rehabilitation are the cornerstone of preventing and managing complications.
Análise Econômica e ambiental frente a implementação das unidades de conservação do munícipio de Quissamã/RJ
Authors: Santana Gildo Rafael de Almeida , Santos Paulo Guilherme Terra dos , Pinto Augusto Eduardo Miranda 
Published: January 2023

O ICMS Ecológico consiste no repasse, segundo critérios ambientais, de parte dos repasses da parcela do Imposto sobre Circulação de Mercadorias e Serviços que cabe aos municípios (ICMS). A política se presta à compensação e incentivo de ações favoráveis ao meio ambiente. Este estudo demonstra os benefícios econômicos gerados após a criação das unidades de conservação e direcionado à conservação ICMS Ecológico, que possui efeitos redistributivos da renda gerada, com sua implementação, benefícios que vem a contribuir economicamente com a captação de recursos estaduais e federais é com a qualidade e manutenção do meio ambiente além da redução de desmatamento. Realizou-se análise da destinação dos recursos recebidos em razão da política, dos gastos municipais com gestão ambiental e da ingerência territorial municipal para compreender o impacto da introdução do critério ecológico de repartição sobre o município que possui uma vasta área de grande biodiversidade ambiente. Os resultados indicam que o município vem sendo beneficiado com a introdução do ICMS Ecológico e mais ainda com a criação das unidades de conservação ambiental implicado em um aumento na conservação ambiental ali existente e, beneficiando economicamente o município por meio da arrecadação de verbas para que possa investir ainda mais em seus projetos. Conclui-se que houve um grande benefício ao município ao implementar novas unidades de conservação, pois as mesmas auxiliam no não desmatamento, na conservação de espécies nativas e em uma fonte de maior geração na captação de ICMS Ecológico para o município de Quissamã, com ressalvas para pontos específicos que podem ser melhorados em seu projeto.
Design of a Web-Based New Student Admission Information System Accompanied by a Midtrans Payment Gateway Payment Method at SMP PGRI 16 Sidoarjo
Authors: Ramadhan Diky Chandra , Rosid Mochammad Alfan 
Published: January 2023

SMP PGRI 16 Sidoarjo is an educational unit with junior high school level with NPSN number 20501661 which has private status and is under the auspices of the Ministry of Education and Culture. SMP PGRI 16 Sidoarjo has its address at Jl. Raden Patah No. 91 E, Pucang Anom, Sidoarjo District, Sidoarjo Regency, East Java Province with postal code 61217.
The problem that is owned by SMP PGRI 16 Sidoarjo is at the time of PPDB implementation, where implementation still takes a long time and requires extra energy for the committee in accepting new students. Starting with students having to come to school to queue for taking forms and filling out the forms provided. In addition, announcement information for prospective students is placed on the bulletin board, so that information may not be fully received by prospective students. For prospective students who have been declared graduated by the student body, prospective students will return to school and make payments offline. And for the process of accepting prospective students using conventional, namely using special notes and processing student data using the Microsoft Excel application, so that data processing of prospective students takes a long time and is not integrated with each other.
Therefore, in this study, it is proposed to make a web-based application for Admission of New Students. It is hoped that it can help the registration process for new students, so that prospective participants do not need to come to school again. Starting from registration, payment of prospective students who have passed and filling out forms are all done online so that it can simplify and shorten the time for new students.
Los filtros culturales y las estrategias del traductor: Estudio de la traducción china de Del Sentimiento Trágico de la Vida basado en la Teoría de Variación
Authors: Chen Huiting 
Published: January 2023

Las variaciones en la traducción son resultado de las medidas que ha adoptado el traductor, las cuales, revelan la historia, el medio sociopolítico y la propia cultura del país receptor. (Álvarez y Vidal, 1996, p. 5) Con este trabajo se pretende revisar las versiones chinas de Del Sentimiento Trágico de la Vida basado en el mecanismo de los filtros culturales de la Teoría de Variación. Tras la introducción y el fundamento teórico, se organiza el análisis a tres niveles: el contexto social, la traducción lingüística y la cultura tradicional, con el objetivo de indagar qué variaciones ha sufrido la traducción china de Del Sentimiento Trágico de la Vida, las posibles razones, así como las estrategias del traductor.
Palabras clave: Teoría de Variación, Filtro cultural, Del Sentimiento Trágico de la Vida, Traducción español-chino, Estudio transcultural
La gestión de proyectos de traducción: una tarea pendiente en los planes de estudio del Grado en Traducción e Interpretación en España
Authors: Quijano Peña Paula 
Published: January 2023

Actualmente, la figura del gestor de proyectos de traducción continúa siendo una gran desconocida para gran parte de los recién egresados del Grado de Traducción e Interpretación en España. No obstante y, debido al auge del sector y del gran volumen de traducciones del mercado, esta figura resulta cada vez más necesaria. Por ello, se ha convertido recientemente en una de las principales salidas dentro del mercado laboral de este sector, aunque sus funciones y competencias siguen siendo, en ocasiones, desconocidas para las nuevas generaciones de traductores.
Esto podría deberse, principalmente, al hecho de que debido a la limitación en tiempo y en créditos ETCS a la que están sujetos los vigentes planes de estudio en el Grado de Traducción e Interpretación en España, en donde la formación con respecto a la gestión de proyectos queda relevada, en ocasiones, a un segundo plano.
En el presente artículo se muestran los resultados obtenidos de una encuesta distribuida entre 41 egresados de dicho grado que ejercen o han ejercido como gestores para comprobar hasta qué punto disponen de las competencias y conocimientos necesarios para ejercer como tal. Finalmente, se analiza la oferta vigente en esta materia, tanto dentro de los planes de estudio del Grado de Traducción e Interpretación, como de posgrado en las universidades españolas para determinar si, en caso de existir carencias a este respecto, podrían estas ser suplidas a posteriori.
Palabras clave: Gestión de Proyectos, Estudio basado en encuesta, Grado en Traducción e Interpretación, Planes de estudio, Sistema ECTS
O uso do software Biome Viewer e da maquete para o estudo dos biomas brasileiros
Authors: Kraisch Aluisiane , Groh Odair , Fuchs Pablo , Rizzi Carlos 
Published: January 2023

As Tecnologias de Informação e Comunicação (TIC) permitem a elaboração de atividades de ensino que tenham como base práticas multi letradas e abordagens multimodais. Ao pensarmos em aulas de Geografia que tenham como base essas perspectivas, podemos desenvolver atividades de ensino interativas e que coloquem o estudante como centro do processo de ensino e aprendizagem. Neste plano de aula pretendemos abordar os Biomas brasileiros utilizando essas diferentes linguagens. Recursos didáticos como o software Biome Viewer, que permite ao estudante observar os Biomas de maneira interativa e representações tridimensionais, como as maquetes, aliados a uma pesquisa bibliográfica e a um seminário de integração, mediados pelo professor, podem contribuir não só para a apreensão dos conteúdos, mas também desenvolver o pensamento espacial.
Lithiated porous silicon nanowires stimulate periodontal regeneration
Authors: Kaasalainen Martti , Zhang Ran , Vashisth Priya , Birjandi Anahid Ahmadi , S'ari Mark , Martella Davide , Isaacs Mark , Makila Ermei , Wang Cong , Moldenhauer Evelin , Clarke Paul , Pinna Alessandra , Caprettini Valeria , Morell Alexander , Addison Owen , Zhang Xuehui , Bergholt Mads , Al-Jamal Khuloud , Angelova-Volponi Ana , Salonen Jarno , Hondow Nicole , Sharpe Paul , Chiappini Ciro 
Published: January 2023

Abstract
Periodontal disease is a significant burden for oral health, causing progressive and irreversible damage to the support structure of the tooth. This complex structure, the periodontium, is composed of interconnected soft and mineralised tissues, posing a challenge for regenerative approaches. Materials combining silicon and lithium are widely studied in periodontal regeneration, as they stimulate bone repair via silicic acid release while providing regenerative stimuli through lithium activation of the Wnt/β-catenin pathway. Yet, existing materials for combined lithium and silicon release have limited control over ion release amounts and kinetics. Porous silicon can provide controlled silicic acid release, inducing osteogenesis to support bone regeneration. Prelithiation, a strategy developed for battery technology, can introduce large, controllable amounts of lithium within porous silicon, but yields a highly reactive material, unsuitable for biomedicine. This work debuts a strategy to lithiate porous silicon nanowires (LipSiNs) which generates a biocompatible and bioresorbable material. LipSiNs incorporate lithium to between 1% and 40% of silicon content, releasing lithium and silicic acid in a tailorable fashion from days to weeks. LipSiNs combine osteogenic, cementogenic and Wnt/β-catenin stimuli to regenerate bone, cementum and periodontal ligament fibres in a murine periodontal defect.
Interface optimization of dissimilar wire arc additive manufactured wall through ANN-TOPSIS conjugate algorithm
Authors: Paul Amrit Raj , Bose S. , Dhar A.R. , Biswas S. , Mukherjee Manidipto , Manivannan R. 
Published: January 2023

Abstract
The development of functionally graded structures (FGS) through the wire arc additive manufacturing (WAAM) technique is frequently associated with a number of interface-related issues that are mostly controlled by the input parameters. However, it is frequently noticed that the input-output correlation of FGS is quite complex, and a general statistic/stochastic optimisation technique is not very helpful in optimising the process objectives. Therefore, ANN-TOPSIS conjugate algorithm is proposed in this study to predict and optimise the Al-Ni and Ni-SS dissimilar interfaces. The proposed model shows more than 95% accurate prediction of interface characteristics along with <15% error between the validated and optimised responses. The metallurgical characterisation revealed the formation of AlNi intermetallic layer at the Al-Ni interface surrounded by Al3Ni at the Al side and AlNi3 at the Ni side closer to the interface. The SS-Ni interface mainly consist of FeNi3. The microhardness of the Al-Ni interface increases as the Al content of the Al-Ni IMC increases. The hardness of the Al-Ni interface is higher than that of the SS-Ni interface.