bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of morphine administration for refractory dyspnoea among hospitalised patients with advanced heart failure: the Morphine-HF study
Authors: Hamatani Yasuhiro , Iguchi Moritake , Moriuchi Kenji , Anchi Yuta , Inuzuka Yasutaka , Nishikawa Ryusuke , Shimamura Kiyotaka , Kondo Hirokazu , Mima Hibiki , Yamashita Yugo , Takabayashi Kensuke , Takenaka Kotoe , Korai Kengo , Kawase Yuichi , Murai Ryosuke , Yaku Hidenori , Nagao Kazuya , Kitano Mariko , Aono Yuya , Kitai Takeshi , Sato Yukihito , Kimura Takeshi , Akao Masaharu 
Published: May 2023

ObjectivesMorphine is effective in alleviating dyspnoea in patients with cancer. We aimed to investigate the effectiveness and safety of morphine administration for refractory dyspnoea in patients with advanced heart failure (HF).MethodsWe conducted a multicentre, prospective, observational study of hospitalised patients with advanced HF in whom morphine was administered for refractory dyspnoea. Morphine effectiveness was evaluated by dyspnoea intensity changes, assessed regularly by both a quantitative subjective scale (Visual Analogue Scale (VAS; graded from 0 to 100 mm)) and an objective scale (Support Team Assessment Schedule—Japanese (STAS-J; graded from 0 to 4 points)). Safety was assessed by vital sign changes and new-onset severe adverse events, including nausea, vomiting, constipation and delirium based on the Common Terminology Criteria for Adverse Events.ResultsFrom 15 Japanese institutions between September 2020 and August 2022, we included 28 hospitalised patients with advanced HF in whom morphine was administered (mean age: 83.8±8.7 years, male: 15 (54%), New York Heart Association class IV: 26 (93%) and mean left ventricular ejection fraction: 38%±19%). Both VAS and STAS-J significantly improved from baseline to day 1 (VAS: 67±26 to 50±31 mm; p=0.02 and STAS-J: 3.3±0.8 to 2.6±1.1 points; p=0.006, respectively), and thereafter the improvements sustained through to day 7. After morphine administration, vital signs including blood pressure, pulse rate and oxygen saturation did not change, and no new-onset severe adverse events occurred through to day 7.ConclusionsThis study suggested acceptable effectiveness and safety for morphine administration in treating refractory dyspnoea in hospitalised patients with advanced HF.
Ten-year follow-up investigation of stroke risk in systemic lupus erythematosus
Authors: Huang Jin-An , Lin Ching-Heng , Wu Ming-Ju , Chen Yi-Hsing , Chang Kuo-Cheng , Hou Chung-Wei 
Published: May 2023

Background and purposeTo analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus (SLE).MethodsA retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance Research Database. Patients with SLE between 2000 and 2008 were registered and matched with two controls by the index date, age, gender and Charlson Comorbidity Index (CCI). These subjects were followed until either stroke event or 31 December 2013. Adjusted HRs (aHRs) for strokes were estimated with Cox regression models, and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival analysis.ResultsIn total, 8310 patients with SLE and 16 620 patients without SLE were included. In general, patients with SLE had higher rates of ischaemic stroke (5.4% vs 3.3%) and haemorrhagic stroke (1.5% vs 0.6%) than in controls. In multivariate analysis adjusted to age, gender, CCI, urbanisation level and antithrombotics uses, aHRs of all strokes, ischaemic stroke and haemorrhagic stroke were 1.73 (95% CI: 1.54 to 1.94), 1.65 (95% CI: 1.45 to 1.87) and 2.24 (95% CI: 1.71 to 2.95), respectively, in patients with SLE. Patients with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE, even 10 years after SLE diagnosis (6.12% vs 3.50%, p<0.001). Antiplatelet use increased the risk of haemorrhagic stroke in SLE group (aHR=1.74, 95% CI: 1.18 to 2.57).ConclusionsPatients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 years. Antiplatelets should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.
Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design
Authors: Zhao Zi-Ai , Qiu Jing , Li Wei , Nguyen Thanh , Wang Shouchun , Shi Huaizhang , Wei Ming , Wang Feng , Li Di , Chen Hui-Sheng 
Published: May 2023

BackgroundOur recent pilot study suggests intra-arterial tenecteplase (TNK) during the first pass of endovascular treatment (EVT) seems safe, may increase first-pass reperfusion and good outcome in acute ischaemic stroke (AIS) patients with large-vessel occlusion (LVO).AimsTo determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24 hours from symptom onset.Sample size estimatesA maximum of 380 patients are required to test the superiority hypothesis with 80% power according to a two-side 0.05 level of significance, stratified by age, gender, baseline systolic blood pressure, prestroke modified Rankin Scale (mRS), baseline National Institute of Health stroke scale, baseline ASPECTS, time from onset to groin puncture, intravenous thrombolysis before EVT, stroke territory and stroke aetiology.DesignIntra-arterial TNK during thrombectomy for acute stroke (BRETIS-TNK II) study is a prospective, randomised, adaptive enrichment, open-label, blinded end point, multicentre study. Eligible AIS-LVO patients are randomly assigned into the experimental group and control group with a ratio of 1:1. The experimental group will be treated with intra-arterial infusion of TNK during EVT. The control group will be treated with standard EVT.OutcomeThe primary end point is a favourable outcome, defined as an mRS score of 0–2 at 90 days. The primary safety end point is symptomatic intracranial haemorrhage within 48 hours, which is defined as an increase in the National Institutes of Health Stroke Scale score of ≥4 points as a result of the intracranial haemorrhage.ConclusionsThe results of BRETIS-TNK II will provide evidence for the efficacy and safety of intra-arterial TNK administration during EVT in AIS patients with LVO.
Constraining the Lorentz-violating bumblebee vector field with big bang nucleosynthesis and gravitational baryogenesis
Authors: Khodadi Mohsen , Lambiase Gaetano , Sheykhi Ahmad 
Published: May 2023

AbstractBy assuming the cosmological principle i.e., an isotropic and homogeneous universe, we consider the cosmology of a vector-tensor theory of gravitation known as the bumblebee model. In this model a single Lorentz-violating timelike vector field with a nonzero vacuum expectation value (VEV) couples to the Ricci tensor and scalar, as well. Taking the ansatz $$B(t)\sim t^\beta $$

B

(
t
)

∼

t
β

for the time evolution of the vector field, where $$\beta $$
β
is a free parameter, we derive the relevant dynamic equations of the Universe. In particular, by employing observational data coming from the Big Bang Nucleosynthesis (BBN) and the matter–antimatter asymmetry in the baryogenesis era, we impose some constraints on the VEV of the bumblebee timelike vector field i.e., $$\xi b^2$$

ξ

b
2

, and the exponent parameter $$\beta $$
β
. The former and the latter limit the size of Lorentz violation, and the rate of the time evolution of the background Lorentz-violating bumblebee field, respectively.
Non-ambiguous and simplified quantum teleportation protocol
Authors: Mastriani Mario 
Published: May 2023

AbstractIn this study, a new version of the quantum teleportation protocol is presented, which does not require a Bell state measurement (BSM) module on the sender side (Alice), a unitary transform to reconstruct the teleported state on the receiver side (Bob), neither a disambiguation process through two classic bits that travel through a classic disambiguation channel located between sender and receiver. The corresponding theoretical deduction of the protocol, as well as the experimental verification of its operation for several examples of qubits through implementation on an optical table, complete the present study. Both the theoretical and experimental outcomes show a marked superiority in the performance of the new protocol over the original version, with more simplicity and lower implementation costs, and identical fidelity in its most complete version.
Noncommutative instantons in diverse dimensions
Authors: Szabo Richard J. , Tirelli Michelangelo 
Published: May 2023

AbstractThis is a mini-review about generalized instantons of noncommutative gauge theories in dimensions 4, 6 and 8, with emphasis on their realizations in type II string theory, their geometric interpretations, and their applications to the enumerative geometry of non-compact toric varieties.
Orthogonal Inner Product Graphs over Finite Fields of Odd Characteristic
Authors: Zhao Shouxiang , Zhang Hengbin , Nan Jizhu , Tang Gaohua 
Published: May 2023

Let

F

q

be a finite field of odd characteristic and

2
ν
+
δ
≥
2

be an integer with

δ
=
0,1

, or 2. The orthogonal inner product graph

O
i

2
ν
+
δ
,
q

over

F

q

is defined, and a class of subgroup of the automorphism groups of

O
i

2
ν
+
δ
,
q

is determined. We show that

O
i

2
ν
+
δ
,
q

is a disconnected graph if

2
ν
+
δ
=
2

; otherwise, it is not. Moreover, we give necessary and sufficient conditions for two vertices and two edges of

O
i

2
ν
+
δ
,
q

, respectively, which are in the same orbit under the action of a subgroup of the automorphism group of

O
i

2
ν
+
δ
,
q

.
The Translation of Johann Arndt’s True Christianity into Dutch and the Distribution of his Books in the Dutch Republic
Authors: Matthias Markus A. 
Published: May 2023

Abstract
The impact of Puritan devotional literature on Reformed and Lutheran piety has been well researched in the past decades. Several studies about Dutch religious culture in the 17th century stress the interconfessional readership of devotional writings as a widespread practice. Obviously, the religious cultures were not so self-contained as the paradigm of confessionalization suggests. Until now we don’t have an exhaustive study over the impact and distribution of Johann Arndt’s devotional literature in the Dutch republic of the 17th century. The common opinion is that Arndt’s True Christianity had no noteworthy influence. In fact, it can be shown that there has been a long and intensive literary production and distribution of the True Christianity and other works of Arndt in Reformed circles in the Dutch Republic.
Rates of Recurrent Marginal Ulcer in Gastric Bypass Patients Undergoing Revisional Surgery
Authors: Pina Luis , Smith Benjamin , Smith Lynzi , Wood G. Craig , Horsley Ryan , Falvo Alexandra , Still Christopher , Petrick Anthony , Obradovic Vladan , Parker David M. 
Published: May 2023

Introduction The rate of marginal ulcer (MU) following primary Roux-en-Y Gastric Bypass (RYGB) is approximately .6-16%. Few studies have evaluated recurrence rates following surgical revision for MU. The primary aim of this study was to determine the rate of MU recurrence following revision. The secondary aim was to evaluate the impact of truncal vagotomy (TV) on the recurrence rates and analyze potential risk factors associated with the recurrence of MU after revision. Methods We conducted a retrospective cohort study examining data at a single tertiary academic medical center. Adult patients with a history of RYGB who underwent gastrojejunostomy revision for recurrent MU between the years of 2003-2020 were included. We sought to determine our overall rate of MU following revision, with and without TV. Additionally, we examined the association of risk factors with MU recurrence. Fisher’s exact test was used to determine the statistical significance of recurrence rates between the groups. Results We included 90 patients in the study. The overall recurrence rate for MU was 16.7%. Of the 90 patients, 35 (35.4%) patients underwent TV at the time of revision. The recurrence rate of MU after GJ revision with TV was 14.3% in comparison to those without TV, 18.2% ( P = .775). Smoking, steroid, alcohol use, history of cardiac surgery/intervention, and helicobacter pylori were not significantly associated with recurrent MU following revision. Conclusions The rate of recurrence after revision for MU is high. Adding TV trended towards decreased MU recurrence after revisional surgery, however not significant. Larger studies are needed to evaluate risk factors associated with recurrent MU after revision.
Internalizing disorders as a mediator of the association between adverse childhood experiences and perceived medication intolerance or poly-allergy
Authors: van den Berk-Clark Carissa , Grant Abigail , Ferber Megan 
Published: May 2023

Objectives There is a well-established link between adverse childhood events, mental health, and physical health conditions. There is also a large literature showing the relationship between medication intolerance or allergies, and poor health outcomes. However, less is understood about the role of medication intolerance and adverse childhood events. Thus, the present study examines the relationship between adverse childhood events, internalizing disorders (depression, anxiety) and medication intolerance. Method Three hundred forty-nine participants were recruited from 11 primary care practices and health networks located in a large, Midwestern metropolitan area. Unrelated linear and Poisson regression was used to determine whether internalizing disorders, such as depression and anxiety, mediated the relationship between adverse childhood experiences (ACEs) and allergies to medications, accounting for error terms in regression equations that were correlated. Results Results indicated an association between ACEs and number of allergies to medication, whereby ACEs was associated with depression, anxiety and number of allergies. Sensitivity analysis confirmed these findings. There was a small but significant indirect effect of anxiety on allergies to medication after bootstrapping. Conclusion This study found that inflammatory responses occurring because of trauma and depression may be increasing medication allergies. However, given the size of the sample, more research is needed to confirm these results. Implications for healthcare providers are discussed.
CEO cognitive competencies in managing turnaround: Complexity and focus
Authors: Liang Xin 
Published: May 2023

This study examines the knowledge structures (KSs) of CEOs of firms that attempted turnaround from performance decline. We developed and tested a theoretical model that describes how two cognitive characteristics of CEOs, complexity and centrality, influence the likelihood of turnaround. It is found that CEO KS centrality directly increases the chance of turnaround. In addition, CEO KS complexity is found to increasingly improve the chance of turnaround as a firm in decline launches a greater extent of strategic change to their organization. Together, in theory, our research suggests that CEO cognitive competencies matter for managing successful turnaround attempts. Practically speaking, the findings of this article imply that to improve their chance of achieving successful turnaround, declining firms should look for CEOs who are cognitively focused or who are cognitively complex enough to engage in the degree of strategic changes launched to save the firm. JEL Classification: L20, M1
Health and Social Care System Preparedness for Dementia Care in Mexico: Current Status and Recommendations to Achieve Optimal Care
Authors: López Ortega Mariana , Astudillo García Claudia I , Farrés Rosa , Gutiérrez Robledo Luis Miguel 
Published: May 2023

In this article, we summarise the findings of the situational analysis of dementia care generated as part of the STRiDE: Strengthening responses to dementia care in developing countries project, including a desk review, a SWOT analysis and views from relevant stakeholders. In addition, the article incorporates the experience of 4 years of work within the STRiDE project of FEDMA, Mexico’s Federation of Alzheimer’s and other dementias and its allied Associations in presenting specific recommendations to optimise dementia care in the country. All the information gathered brings together a detailed understanding of the current dementia care systems of diagnosis, treatment, and support in general and what is lacking, allowing for the generation of general recommendations to enhance the isolated efforts currently available and amplify their impact, as well as strategies to generate new services currently unavailable, but urgently needed.
Vertebral and Basilar Artery Dissection in a Patient With Alport Syndrome
Authors: Talbot-Stetsko Haley K. , Saleh Sara , Brent Ashley , Camelo-Piragua Sandra , Gordon David , Williamson Craig A. 
Published: May 2023

Basilar artery occlusion (BAO) is a rare cause of stroke associated with significant morbidity and mortality. It is most frequently thromboembolic in nature, but may be caused by vertebral artery dissection. We present a case of BAO in a 36-year-old woman with Alport syndrome. She was treated with emergent thrombectomy via the right vertebral artery with return to baseline neurological status. Her clinical status deteriorated later the same day and she was found to have re-occlusion. Repeat thrombectomy was complicated by persistent re-occlusion requiring 7 passes to achieve reperfusion. Unfortunately, her neurological exam remained poor and she was transitioned to comfort care, expiring on admission day 3. An autopsy demonstrated acute dissection of the left vertebral artery, basilar artery, and bilateral posterior cerebral arteries. Alport syndrome is a type IV collagenopathy most known for causing kidney disease. It may also be associated with vascular fragility as type IV collagen forms a significant component of the vascular basement membrane. There are reports of aortic, coronary, and cervical dissections, but few reports of intracranial dissections in patients with Alport syndrome. While iatrogenic dissection cannot be ruled out, the histological findings in this case are most consistent with spontaneous arterial dissection as the cause of her initial neurologic presentation. This highlights the need for further investigation into the relationship between Alport syndrome and vascular fragility and should alert clinicians to the possibility of intracranial dissection in patients with AS.
Accessibility of Water (H2O) and Untouchability in India
Authors: Sinha Kunal 
Published: May 2023

Caste has always played an imperative role in shaping and reshaping the trajectories of any development in India. Scheduled Castes, or the lower castes, signify the categories devoid of resources generally confined to the upper caste in the social structure of Indian society. Due to the role of Dr B. R. Ambedkar in drafting the Indian Constitution, some rights and safeguards were granted to the lower castes, which comprise 16.6% of the total Indian population. From the 2001 census to 2011, the Scheduled Castes population increased by 20.8% (Express News Service, 2013). Through their policies, science, technology and innovation have often brought societal transformation by generating various avenues. The opportunity has remarkably influenced people’s habits and way of life. The hate and hate crime associated with the caste identity are practised explicitly and implicitly depending upon the circumstances. The so-called lower caste people are aware of the situation and cannot do anything to change the mindset of the so-called upper caste people. The paper is not suggestive but engages primarily by referring to the context of discrimination meted out to the Scheduled Castes people for accessibility of water (H2O- two molecules of hydrogen and one molecule of oxygen). The untouchables, or the untouchability associated with them, have been subjected to and made to amalgamate with cultural, social and political status and interaction. Lower caste people are humiliated and killed for touching, entering temples, drawing water (H2O) from upper caste people’s wells, or, for that matter, lower caste children being segregated from other children in the school for the Mid-Day Meals have become so functional and way of life that it does not allow the society to come together and address barbaric mindsets and practices. The paper is based on secondary sources.
Comparison of the effects of electronic cigarette vapours and tobacco smoke extracts on human neutrophilsin vitro
Authors: Richards Guy A. , Theron Annette J. , van den Bout Iman , Anderson Ronald , Feldman Charles , van Zyl Smit Richard , Chang Ju-Wei , Tintinger Gregory R. 
Published: May 2023

BackgroundElectronic cigarettes (ECs) are electronic aerosol delivery systems composed of nicotine and various chemicals, which are widely used to facilitate smoking cessation. Although ECs are considered safer than cigarettes, they do, however, contain chemical toxicants, some of which may interact with cells of the host's innate immune system of which neutrophils constitute a key component.MethodsThe current study was designed to compare the effects of aqueous EC aerosol extracts (ECEs; with or without nicotine) with those of cigarette smoke extract (CSE) on neutrophil and platelet reactivityin vitro.Neutrophil reactivity is characterised by the generation of reactive oxygen species (ROS), degranulation (elastase release) and the release of extracellular DNA (neutrophil extracellular trap (NET) formation: NETosis), which were measured using chemiluminescence, spectrophotometric and microscopic procedures, respectively. Platelet reactivity was measured according to the magnitude of upregulated expression of the adhesion molecule CD62P on activated cells using a flow cytometric procedure.ResultsExposure of neutrophils to either ECEs or CSE caused a significant inhibition of ROS generation and elastase release byN-formyl-l-methionyl-l-leucyl-l-phenylalanine (1 µM)-activated neutrophils. Pre-treatment of neutrophils with CSE also resulted in a marked attenuation of phorbol 12-myristate 13-acetate (6.25 nM)-mediated release of extracellular DNA, which was unaffected by the ECEs. Similarly, CSE, but not the ECEs, inhibited the expression of CD62P by platelets activated with ADP (100 µM).ConclusionsThese observations suggest that ECE aerosols may inhibit some of the immuno-protective activities of neutrophils such as ROS production and elastase release by activated cells, the effect of which was not enhanced by inclusion of nicotine. The inhibitory effects of CSE were significantly more pronounced than those of ECEs, especially so for suppression of NET formation and platelet activation. If operativein vivo, these harmful immunosuppressive effects of ECEs may compromise intrinsic pulmonary antimicrobial defence mechanisms, albeit less so than cigarette smoke.