bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional outcome and athletic level after arthroscopic repair followed by triple pelvic osteotomy in patients with labral tears resulting from acetabular dysplasia
Authors: Jaber Ayham , Bangert Yannic , Gather Katharina , Hagmann Sébastien , Renkawitz Tobias , Barié Alexander 
Published: June 2023

Abstract
Background
Patients with acetabular dysplasia are at a higher risk of developing symptomatic labral tears. Isolated treatments that address these pathologies are well established. Combined treatment with hip reorientation osteotomy using Bernese periacetabular osteotomy in addition to arthroscopic labral repair show good results. Studies that report the outcome in patients who received both arthroscopic labral repair and a triple pelvic osteotomy (TPO) are lacking. The aim of this study is to investigate the short to midterm functional outcome and activity level in these patients.

Methods
This case series retrospectively included 8 patients (2 male, 6 female) with acetabular dysplasia (lateral center-edge angle [LCEA] ≤ 25°) and a labral tear on magnetic resonance arthrography (MRA). All patients underwent arthroscopic labral repair followed by TPO after an average period of 3 months (range 2–6). Average age at the time of surgery was 25 years (range 15–37). Patients were followed up and the following main parameters were assessed: LCEA, modified Harris hip score (mHSS), Tegner score, UCLA score, patient satisfaction on a scale of 1–4.

Results
The mean follow-up was 19 months (range 15–25). The mean LCEA increased from 18° to 37° (p < 0.0001). The mHSS improved from a mean of 79 to 94 on final follow-up (p = 0.00123). The Tegner and UCLA scores had a median of 4 and 5, respectively. The mean LCEA increased from 18° to 37° (p < 0.0001). The mean patient satisfaction was 3.6.

Conclusion
Patients with evidence of a labral tear resulting from acetabular dysplasia benefit from arthroscopic repair followed by a TPO. The literature still lacks evidence that labral repair and reorientation osteotomy produce superior outcome compared to osteotomy alone. Treatment should consider clinical presentation in addition to radiological findings with emphasis on MRA.
Positive Lyapunov Exponent in the Hopf Normal Form with Additive Noise
Authors: Chemnitz Dennis , Engel Maximilian 
Published: June 2023

AbstractWe prove the positivity of Lyapunov exponents for the normal form of a Hopf bifurcation, perturbed by additive white noise, under sufficiently strong shear strength. This completes a series of related results for simplified situations which we can exploit by studying suitable limits of the shear and noise parameters. The crucial technical ingredient for making this approach rigorous is a result on the continuity of Lyapunov exponents via Furstenberg–Khasminskii formulas.
Clinical outcomes of vacuum-dehydrated amniotic membrane (Omnigen) mounted on contact lens (Omnilenz) in eyes with acute chemical eye injuries
Authors: Lotfy Nancy M. , Al Rashidi Salah , Hagras Sherein M. 
Published: June 2023

Abstract
Background
Omnigen is a vacuum-dehydrated amniotic membrane transplant. It can be delivered to the eye pre-mounted on a special bandage contact lens (Omnilenz) that enables its application without the need for sutures or glue; the aim of this study is to evaluate the short-term clinical outcomes of Omnilenz-Omnigen complex in eyes with acute chemical injury (CEI).

Methods
A prospective interventional study included patients with different grades of acute CEI attending the casualty between July 2021 and November 2022. All patients received first aid measures followed by the application of Omnilenz-Omnigen within the first 2 days. Patients were followed up for at least 1 month. Primary outcomes include epithelial defect and limbal ischemia. Secondary outcomes include best-corrected visual acuity (BCVA) and tolerability.

Results
The study included 23 eyes of 21 patients with acute CEI mostly due to alcohol (34.8%). After the 1st application, the size of the epithelial defect showed a statistically significant reduction (p = 0.016) with improvement in BCVA (p < 0.001). Restoration of the limbal vascularity was obtained in 56.5% of the eyes. Repeated application of Omnilenz was required in 5 eyes (21.7%). The size of the epithelial defect was reduced after the second application (p = 0.504) with improved BCVA (p = 0.185). After 1st month, complete epithelial healing was achieved in all the eyes. Mild limbal ischemia persists in 3 (13%) of the eyes. Final BCVA showed statistically significant improvement (p < 0.001). None of the patients develops any serious complications.

Conclusion
Omnilenz proved to be easy to apply and well tolerated by patients, with promising clinical outcomes.
Mixed methodology in human brain research: integrating MRI and histology
Authors: Alkemade Anneke , Großmann Rosa , Bazin Pierre-Louis , Forstmann Birte U. 
Published: June 2023

AbstractPostmortem magnetic resonance imaging (MRI) can provide a bridge between histological observations and the in vivo anatomy of the human brain. Approaches aimed at the co-registration of data derived from the two techniques are gaining interest. Optimal integration of the two research fields requires detailed knowledge of the tissue property requirements for individual research techniques, as well as a detailed understanding of the consequences of tissue fixation steps on the imaging quality outcomes for both MRI and histology. Here, we provide an overview of existing studies that bridge between state-of-the-art imaging modalities, and discuss the background knowledge incorporated into the design, execution and interpretation of postmortem studies. A subset of the discussed challenges transfer to animal studies as well. This insight can contribute to furthering our understanding of the normal and diseased human brain, and to facilitate discussions between researchers from the individual disciplines.
Impulse für eine nachhaltige Stahlproduktion – Aufbereitungstechnische Charakterisierung von Reststoffen der Stahlwerksindustrie
Authors: Marousek Lukas , Flachberger Helmut , Sorger Christoph , Griessacher Thomas 
Published: June 2023

ZusammenfassungStahlwerke, die einen LD-Konverter oder Elektrolichtbogenofen betreiben, leisten einen maßgebenden Beitrag, die in Schrotten enthaltenen Wertmetalle wieder verfügbar zu machen und damit dem Stoffkreislauf abermals zuzuführen. Für gleichmäßige Stahlproduktqualitäten werden nur ausgewählte Schrotte eingesetzt, welche wiederum gewisse Qualitätskriterien aufweisen müssen. Trotz hoher Schrottqualitäten unterliegen Schrotte gewissen inhaltlichen Schwankungen, je nach Sorte, Lieferant, Herkunft oder Jahreszeit. Um diese Schwankungen so gering wie möglich zu halten, wird vor dem Schrotteinsatz eine so genannte Störstoffentfrachtung durchgeführt, wobei z. B. mittels Magnetscheidung die eingesetzte Qualität der zum Einsatz gelangenden Schrotte verbessert wird.Die Stahl- und Walzwerk Marienhütte GmbH plant zu diesem Zweck eine Investition in eine neue Aufbereitungsanlage. Das Stahlwerk erhofft sich so verbesserte Prozessbedingungen, beispielsweise ein verbessertes metallisches Ausbringen, eine verringerte Hüttenschottermenge und eine Reduktion unerwünschter Metalle wie Kupfer oder Aluminium. Aufbereitungstechnische Untersuchungen vom Labor- bis zum Pilotmaßstab zeigten zudem das hohe Potenzial für eine weitere Verwendung der unmagnetischen Schrottstoffströme auf.
COMET Module FuLIBatteR – Auf der Suche nach der besten Lösung für das Recycling von Lithium-Ionen-Batterien der Zukunft
Authors: Rutrecht Bettina , Rieger Johannes , Nigl Thomas 
Published: June 2023

ZusammenfassungFuLIBatteR, ein Modul (bestehend aus drei Sub-Projekten) koordiniert vom metallurgischen Kompetenzzentrum K1-MET GmbH, und gefördert im Rahmen des österreichischen Kompetenzzentrums COMET der Österreichischen Forschungsförderungsgesellschaft (FFG), untersucht in Zusammenarbeit mit internationalen Partnern aus Industrie und Wirtschaft die Steigerung der Recyclingfähigkeit von Lithium-Ionen-Batterien (LIB). Im Fokus steht dabei die Rückgewinnung von Wertmetallen wie Aluminium, Kupfer, Kobalt, Mangan und Nickel und der kritischen Rohstoffe Lithium, Phosphor, Silizium und Graphit. Am Ende des Moduls mit einer Laufzeit von vier Jahren wird die Weiterentwicklung und Kombination bestehender LIB-Behandlungsverfahren aus den Bereichen Pyrometallurgie, (Bio‑)Hydrometallurgie und mechanisch-physikalischer Aufbereitung erwartet, welche zu einer Best-Practice-Behandlungsroute führen kann. Diese optimierte Route wird am Ende der Projektzeit einer ökologischen Bewertung im Vergleich zum bestehenden Referenzverfahren (LIBRES/REDUX) unterzogen, um Maßnahmen brach liegender Verbesserungspotentiale für das LIB-Recycling aufzuzeigen. Stoffkreisläufe kritischer Rohstoffe werden geschlossen und die Versorgungssicherheit der darauf angewiesenen Industriezweige verbessert. Durch die Bewertung ökologischer Auswirkungen werden Daten generiert, die bisher nicht oder kaum öffentlich zugänglich waren. Das ermöglicht die Diskussion über ökologisch sinnvolles LIB-Recycling im Sinne einer nachhaltigen Produktion.
Standardization of rectal cancer surgery and bowel preparation in Austria
Authors: Widmann Kerstin M. , Dawoud Christopher , Harpain Felix , Aigner Felix , Presl Jaroslav , Rosen Harald , Zitt Matthias , Schoppmann Sebastian F. , Emmanuel Klaus , Riss Stefan 
Published: June 2023

Summary
Background
Standardized management of colorectal cancer is crucial for achieving an optimal clinical and oncological outcome. The present nationwide survey was designed to provide data about the surgical management of rectal cancer patients. In addition, we evaluated the standard approach for bowel preparation in all centers in Austria performing elective colorectal surgery.

Methods
The Austrian Society of Surgical Oncology (ACO[“Arbeitsgemeinschaft für chirurgische Onkonlogie”]-ASSO) conducted a multicenter questionnaire-based study comprising 64 hospitals between October 2020 and March 2021.

Results
The median number of low anterior resections performed annually per department was 20 (range 0–73). The highest number was found in Vienna, with a median of 27 operations, whereas Vorarlberg was the state with the lowest median number of 13 resections per year. The laparoscopic approach was the standard technique in 46 (72%) departments, followed by the open approach in 30 (47%), transanal total mesorectal excision (TaTME) in 10 (16%) and robotic surgery in 6 hospitals (9%). Out of 64 hospitals 51 (80%) named a standard for bowel preparation before colorectal resections. No preparation was commonly used for the right colon (33%).

Conclusion
Considering the low number of low anterior resections performed in each hospital per year in Austria, defined centers for rectal cancer surgery are still scarce. Many hospitals did not transfer recommended bowel preparation guidelines into clinical practice.
“Now is the time for institutions to be investing in growing exercise programs as part of standard of care”: a multiple case study examining the implementation of exercise oncology interventions
Authors: Czosnek Louise , Rankin Nicole M. , Cormie Prue , Murnane Andrew , Turner Jane , Richards Justin , Rosenbaum Simon , Zopf Eva M. 
Published: June 2023

Abstract
Background
Implementation science seeks to systematically identify determinants, strategies, and outcomes within a causal pathway to help explain successful implementation. This process is applied to evidence-based interventions (EBIs) to improve their adoption, implementation, and sustainment. However, this method has not been applied to exercise oncology services, meaning we lack knowledge about implementing exercise EBIs in routine practice. This study aimed to develop causal pathways from the determinants, strategies (including mechanism of change), and implementation outcomes to explain exercise EBIs implementation in routine cancer care.

Methods
A multiple-case study was conducted across three healthcare sites in Australia. Sites selected had implemented exercise within routine care for people diagnosed with cancer and sustained the delivery of services for at least 12 months. Four data sources informed the study: semi-structured interviews with staff, document reviews, observations, and the Program Sustainability Assessment Tool (survey). Framework analysis was applied to understand the findings. The Implementation Research Logic Model was used to identify commonalities in implementation across sites and develop causal pathways.

Results
Two hundred and eighteen data points informed our findings. Across sites, 18 determinants and 22 implementation strategies were consistent. Sixteen determinants and 24 implementation strategies differed across sites and results of implementation outcomes varied. We identified 11 common pathways that when combined, help explain implementation processes. The mechanisms of implementation strategies operating within the pathways included (1) knowledge, (2) skills, (3) secure resources, (4) optimism, and (5) simplified decision-making processes associated with exercise; (6) relationships (social and professional) and support for the workforce; (7) reinforcing positive outcomes; (8) capability to action plan through evaluations and (9) interactive learning; (10) aligned goals between the organisation and the EBI; and (11) consumer-responsiveness.

Conclusion
This study developed causal pathways that explain the how and why of successful implementation of exercise EBIs in cancer care. These findings can support future planning and optimisation activities by creating more opportunities for people with cancer to access evidence-based exercise oncology services.

Implications for cancer survivors
Understanding how to implement exercise within routine cancer care successfully is important so cancer survivors can experience the benefits of exercise.
Combining portable cone penetration test and electrical resistivity tomography to assess residual risks after shallow landslides: a case at the Hokkaido Eastern Iburi earthquake in 2018 in Japan
Authors: Yoshihara Naoyuki , Umezawa Ryosuke 
Published: June 2023

AbstractLandscapes disturbed by shallow landslides present several residual risks. For example, residual soils on sliding surfaces may lead to the re-occurrence of shallow landslides, and landslide deposits on valley floors may introduce multiple hazards associated with river blocking or landslide damming. Despite such risks, few studies have investigated the residual risks following shallow landslides, and thus, no methodology has been established for assessing such risks. In this study, we combined portable cone penetration test (PCPT) and electrical resistivity tomography (ERT) to investigate the post-event risks associated with a landslide scar resulting from the 2018 Hokkaido Eastern Iburi earthquake (HEIE) in Japan. The multi-point PCPT identified the interface between a weak volcanic soil layer and underlying weathered sedimentary rocks. This interface exhibited an abrupt spatial change in resistivity, ranging from 20 to 100 Ωm. The thickness of the residual soil layer was 0.3–3.2 m and that of the landslide deposit exceeded 2.0 m. An infinite-slope stability analysis was performed to predict the re-occurrence of shallow landslides due to a lower intensity earthquake than that of HEIE in this region. Considering the area affected by the HEIE and the physical properties of soil layers, our findings imply a widespread risk of re-occurrence of shallow landslides over an area of 20 km × 20 km. Although the areal coverage of the combined ERT/PCPT method needs to be extended, it is effective for assessing the residual risks associated with shallow landslides.
Geometric and Inertial Properties of the Pig Head and Brain in an Anatomical Coordinate System
Authors: Soltan Nikoo , Siegmund Gunter P. , Cripton Peter A. , Jones Claire F. 
Published: June 2023

AbstractPorcine models in injury biomechanics research often involve measuring head or brain kinematics. Translation of data from porcine models to other biomechanical models requires geometric and inertial properties of the pig head and brain, and a translationally relevant anatomical coordinate system (ACS). In this study, the head and brain mass, center of mass (CoM), and mass moments of inertia (MoI) were characterized, and an ACS was proposed for the pre-adolescent domestic pig. Density-calibrated computed tomography scans were obtained for the heads of eleven Large White × Landrace pigs (18–48 kg) and were segmented. An ACS with a porcine-equivalent Frankfort plane was defined using externally palpable landmarks (right/left frontal process of the zygomatic bone and zygomatic process of the frontal bone). The head and brain constituted 7.80 ± 0.79% and 0.33 ± 0.08% of the body mass, respectively. The head and brain CoMs were primarily ventral and caudal to the ACS origin, respectively. The mean head and brain principal MoI (in the ACS with origin at respective CoM) ranged from 61.7 to 109.7 kg cm2, and 0.2 to 0.6 kg cm2, respectively. These data may aid the comparison of head and brain kinematics/kinetics data and the translation between porcine and human injury models.
Randomized phase III trial of a neoadjuvant regimen of four cycles of adriamycin plus cyclophosphamide followed by four cycles of docetaxel (AC4-D4) versus a shorter treatment of three cycles of FEC followed by three cycles of docetaxel (FEC3-D3) in node-positive breast cancer (Neo-shorter; NCT02001506)
Authors: Hwang Inhwan , Kim Jeong Eun , Jeong Jae Ho , Ahn Jin-Hee , Jung Kyung Hae , Son Byung Ho , Kim Hak Hee , Shin Junyoung , Lee Hee Jin , Gong Gyungyub , Kim Sung-Bae 
Published: June 2023

Abstract
Purpose
To determine whether six cycles of FEC3-D3 has a comparable efficacy to eight of AC4-D4.

Methods
The enrolled patients (pts) were clinically diagnosed with stage II or III breast cancer. The primary endpoint was a pathologic complete response (pCR), and the secondary endpoints were 3 year disease-free survival (3Y DFS), toxicities, and health-related quality of life (HRQoL). We calculated that 252 pts were needed in each treatment group to enable the detection of non-inferiority (non-inferiority margin of 10%).

Results
In terms of ITT analysis, 248 pts were finally enrolled. The 218 pts who completed the surgery were included in the current analysis. The baseline characteristics of these subjects were well balanced between the two arms. By ITT analysis, pCR was achieved in 15/121 (12.4%) pts in the FEC3-D3 arm and 18/126 (14.3%) in the AC4-D4 arm. With a median follow up of 64.1 months, the 3Y DFS was comparable between the two arms (75.8% in FEC3-D3 vs. 75.6% in AC4-D4). The most common adverse event (AE) was Grade 3/4 neutropenia, which arose in 27/126 (21.4%) AC4-D4 arm pts vs 23/121 (19.0%) FEC3-D3 arm cases. The primary HRQoL domains were similar between the two groups (FACT-B scores at baseline, P = 0.35; at the midpoint of NACT, P = 0.20; at the completion of NACT, P = 0.44).

Conclusion
Six cycles of FEC3-D3 could be an alternative to eight of AC4-D4. Trial registration ClinicalTrials.gov NCT02001506. Registered December 5,2013.https://clinicaltrials.gov/ct2/show/NCT02001506
A Practice Pathway for the Treatment of Night Wakings in Children with Autism Spectrum Disorder
Authors: Galion Anjalee W. , Farmer Justin G. , Connolly Heidi V. , Allhusen Virginia D. , Bennett Amanda , Coury Daniel L. , Lam Janet , Neumeyer Ann M. , Sohl Kristin , Witmans Manisha , Malow Beth A. ,   Autism Treatment Network/Autism Intervention Research Network on Physical Health (ATN/AIR-P) Sleep Committee
Published: June 2023

AbstractChildren with autism spectrum disorder (ASD) report high rates of sleep problems. In 2012, the Autism Treatment Network/ Autism Intervention Research Network on Physical Health (ATN/AIR-P) Sleep Committee developed a pathway to address these concerns. Since its publication, ATN/AIR-P clinicians and parents have identified night wakings as a refractory problem unaddressed by the pathway. We reviewed the existing literature and identified 76 scholarly articles that provided data on night waking in children with ASD. Based on the available literature, we propose an updated practice pathway to identify and treat night wakings in children with ASD.
On the origin of power-scaling exponents in silica aerogels
Authors: Aney Shivangi , Pandit Prakul , Ratke Lorenz , Milow Barbara , Rege Ameya 
Published: June 2023

AbstractThe macroscopic properties of open-porous cellular materials hinge upon the microscopic skeletal architecture and features of the material. Typically, bulk material properties, viz. the elastic modulus, strength of the material, thermal conductivity, and acoustic velocity, of such porous materials are expressed in terms of power-scaling laws against their density. In particular, the relation between the elastic modulus and the density has been intensively investigated. While the Gibson and Ashby model predicts an exponent of 2 for ideally connected foam-like open-cellular solids, the exponent is found to lie between 3 and 4 for silica aerogels. In this paper, we investigate the origins of this scaling exponent. Particularly, the effect of the pearl-necklace-like skeletal features of the pore walls and that of the random spatial arrangement is extensively computationally studied. It is shown that the latter is the driving factor in dictating the scaling exponent and the rest of the features play a negligible or no role in quantifying the scaling exponent.Graphical Abstract
The role of GLUT2 in glucose metabolism in multiple organs and tissues
Authors: Sun Bo , Chen Hui , Xue Jisu , Li Peiwu , Fu Xu 
Published: June 2023

AbstractThe glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis.
Characteristic of Przewalski horses population from Askania-Nova reserve based on genetic markers
Authors: Musiał Adrianna D. , Ropka-Molik Katarzyna , Stefaniuk-Szmukier Monika , Myćka Grzegorz , Bieniek Agnieszka , Yasynetska Nataliya 
Published: June 2023

AbstractPrzewalski horses are considered the last living population of wild horses, however, they are secondarily feral offspring of herds domesticated ~ 5000 years ago by the Botai culture. After Przewalski horses were almost extinct at the beginning of the twentieth century, their population is about 2500 individuals worldwide, with one of the largest breeding centers in Askania-Nova Biosphere Reserve (Ukraine). The research aimed to establish the maternal variation of Przewalski horses population maintained in Askania-Nova Reserve based on mitochondrial DNA hypervariable 1 and hypervariable 2 regions profiling, as well as, analysis of Y chromosome single nucleotide polymorphism unique for Przewalski horses, and coat color markers: MC1R and TBX3. The mtDNA hypervariable regions analysis in 23 Przewalski horses allowed assigning them to three distinctly different haplotypes, showing the greatest similarity to the Equus caballus reference, the Equus przewalskii reference, and to extinct species—Haringtonhippus. The Y chromosome analysis using fluorescently labelled assays differentiated horses in terms of polymorphism (g731821T>C) characteristic of Equus przewalskii. All male individuals presented genotype C characteristics for Przewalski horses. The polymorphisms within the coat color genes indicated only native, wild genotypes. The Y chromosome and coat color analysis denied admixtures of the tested horses with other Equidae.