bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the Tacrolimus Trough Level Adequately Predict Drug Exposure in Patients Requiring a High Tacrolimus Dose?
Authors: Haverals Lien , Roosens Laurence , Wouters Kristien , Marquet Pierre , Monchaud Caroline , Massart Annick , Abramowicz Daniel , Hellemans Rachel 
Published: March 2023

Background.
Tacrolimus (Tac) has a narrow therapeutic range. Dosing is generally targeted at Tac trough levels (C
0), notwithstanding conflicting reports on the correlation between Tac C
0 and systemic exposure measured by the area-under-the-concentration-over-time curve (AUC). The Tac dose required to meet the target C
0 varies highly among patients. We hypothesized that patients requiring a relatively high Tac dose for a certain C
0 may show a higher AUC.

Methods.
We retrospectively analyzed data from 53 patients in which a 24-h Tac AUC24 estimation was performed at our center. Patients were divided into those taking a low (≤0.15 mg/kg) or high (>0.15 mg/kg) once-daily Tac dose. Multiple linear regression models were used to investigate if the association between C
0 and AUC24 changes according to dose level.

Results.
Despite the large difference in mean Tac dose between the low- and high-dose group (7 versus 17 mg/d), C
0 levels were similar. However, the mean AUC24 was substantially higher in the high-dose group (320 ± 96 h·μg/L versus 255 ± 81 h·μg/L, P < 0.001). This difference remained significant after adjusting for age and race. For a same C
0, every 0.01 mg/kg increase in Tac dose resulted in an AUC24 increase of 3.59 h·μg/L.

Conclusions.
This study challenges the general belief that C
0 levels are sufficiently reliable to estimate systemic drug exposure. We demonstrated that patients requiring a relatively high Tac dose to attain therapeutic C
0 levels have higher drug exposure and could therefore potentially be overdosed.
Amino acid substitution in the S1 or CH1-CH2 linker domain of TRPM4: Two newTRPM4variants found in complete heart block patients lead to gain of expression and gain of current
Authors: Boukenna Mey , Arullampallam Prakash , Taib Choshiman , Guichard Sabrina , Rougier Jean-Sébastien , Gollob Michael H. , Abrie Hugues 
Published: March 2023

Withdrawal Statement“The authors have withdrawn their manuscript owing to the following: In an effort to conduct blinded reproducibility experiments, they encountered difficulties in reproducing a portion of the data pertaining to the pathogenicity of the variants. While the clinical data presented in the manuscript are not affected, they are actively working to address and resolve these issues. The authors will resubmit the manuscript once they have ensured the accuracy and integrity of all the experimental data. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding authors.”
Interlinkages of cryptocurrency and stock markets during the COVID-19 pandemic by applying a QVAR model
Authors: Yen Nguyen Hong , Ha Le Thanh 
Published: March 2023

PurposeThis paper aims to study the interlinkages between cryptocurrency and the stock market by characterizing their connectedness and the effects of the COVID-19 crisis on their relations.Design/methodology/approachThe author employs a quantile vector autoregression (QVAR) to identify the connectedness of nine indicators from January 1, 2018, to December 31, 2021, in an effort to examine the relationships between cryptocurrency and stock markets.FindingsThe results demonstrate that the pandemic shocks appear to have influences on the system-wide dynamic connectedness. Dynamic net total directional connectedness implies that Bitcoin (BTC) is a net short-duration shock transmitter during the sample. BTC is a long-duration net receiver of shocks during the 2018–2020 period and turns into a long-duration net transmitter of shocks in late 2021. Ethereum is a net shock transmitter in both durations. Binance turns into a net short-duration shock transmitter during the COVID-19 outbreak before receiving net shocks in 2021. The stock market in different areas plays various roles in the short run and long run. During the COVID-19 pandemic shock, pairwise connectedness reveals that cryptocurrencies can explain the volatility of the stock markets with the most severe impact at the beginning of 2020.Practical implicationsInsightful knowledge about key antecedents of contagion among these markets also help policymakers design adequate policies to reduce these markets' vulnerabilities and minimize the spread of risk or uncertainty across these markets.Originality/valueThe author is the first to investigate the interlinkages between the cryptocurrency and the stock market and assess the influences of uncertain events like the COVID-19 health crisis on the dynamic interlinkages between these two markets.
The impact of differentiated empowering leadership on employees’ depression: moderation of employees’ envy and gender
Authors: Qasim Neelam , Arshad Muhammad , Farooq Omer , Raoof Rabeeya 
Published: March 2023

Purpose
This study aims to investigate the effect of differentiated empowering leadership on employees’ depression. Using the behavioral theory of depression, this study further explores the simultaneous moderation of gender and employees’ envy on the relationship between such leadership and employees’ depression.

Design/methodology/approach
Data were collected using two surveys conducted with a time lag of one week. In Time 1, data on differentiated empowering leadership and employees’ envy were collected. After a week, data on employees’ depression were collected. Model testing was conducted using data on a sample of 420 employees from 87 departments in 27 service sector organizations in Pakistan. Hypotheses were tested using the structural equation modeling technique in Mplus.

Findings
Results indicate that perceived differentiated empowering leadership positively affects employees’ depression. In addition, this positive effect is further moderated by employees’ envy and gender simultaneously, such that this effect is weakest among the male individuals who feel low envy, whereas, for highly envious females, this effect is strongest.

Originality/value
To the best of the authors’ knowledge, this is the first study to examine the effect of differentiated empowering leadership on employees’ depression along with the moderation of employees’ envy and gender. Furthermore, this study provides some policy implications based on its findings to decrease employees’ depression.
Effect of natural resources rents on income inequality in sub-Saharan Africa: exploring the direct and indirect transmission mechanisms
Authors: Akpa Armand Fréjuis 
Published: March 2023

Purpose
The reduction of income inequality and the ways to fight against it are source of debate among scientific communities and policymakers. Rents from natural resources that African countries are endowed with remain one way to cope with income inequality, but its influence on income inequality is mixed. Thus, the purpose of this paper is to explore the direct and indirect transmission mechanisms through which natural resources rents can affect income inequality in sub-Saharan Africa.

Design/methodology/approach
This study obtained data on income inequality from the Standardised World Income Inequality Data database, natural resources rents from World Bank’s Development Indicators and education from United Nations Development Programme for the period 1990–2018. It was analysed using system generalised method of moments.

Findings
The results of this study showed that natural resources rents solely increased income inequality, but its interaction with education significantly reduced income inequality.

Research limitations/implications
These findings suggest that the reduction of income inequality by natural resources rents passes through a good education system in sub-Saharan African countries.

Originality/value
In previous studies, authors analysed the role of education in the relationship between natural resources rents and income inequality by inserting the two variables separately in the model. But in this paper, the author analysed the role of education in the relationship between natural resources rents and income inequality by using the interaction of natural resources rents and education.
Economic migrants in the Czech segmented labour market: Covid-19 as a magnifying glass
Authors: Gheorghiev Olga 
Published: March 2023

PurposeThis study examines Covid-19-related policies as a showcase for priorities in migration governance, the role of the state and employers’ associations, as well as gaps in social security and social protection.Design/methodology/approachThis paper looks at how immigration interacts with the labour market in the Czech Republic through the prism of the varieties of capitalism framework and its relation to the concepts of labour market segmentation and flexibility.FindingsThe findings show that pandemic-related measures focused on continuously adjusting a legislative framework granting access to third-country workers. However, protective measures that would guarantee migrant workers and their families access to social rights, such as healthcare, were lacking. In this context, several lines of segmentation are observed: between migrant workers in standard employment and those in non-standard employment, when looking at their access to healthcare; between migrants hired directly by employers and those working through temporary agencies in terms of their wages, stability and protection; and, at a sectoral level, between the skilled workforce and migrants that are pushed to low-qualified poorly paid, and routinised jobs.Originality/valueThis paper expands the existing literature on the preferences and influence of governments, employers and trade unions regarding the demand for foreign labour in varieties of capitalism by adding the perspective of a Central European economic model. At the same time, its findings contribute to the understanding that labour market inequalities are not fostered on the supply side of migrant labour, through exogenous societal or cultural characteristics specific to countries of origin, but rather through institutionalised measures, practices and policies in countries of destination.
Unspoken teacher conflict: uncovering female novice teachers' conflict experiences in professional learning community
Authors: Hou Yansi , Chen Shuangye , Yu Shulin 
Published: March 2023

PurposeThe professional development of novice teachers is receiving increased attention. Although conflict is regarded as an essential factor affecting the effectiveness of the school professional learning community, it is often hidden unspokenly. This study uncovers the conflict experiences of female novice teachers in an Asian cultural context and investigates how such experiences influence their professional development and emotions.Design/methodology/approachThe case study approach was adopted. Four participants were selected according to specific criteria, and two rounds of semi-structured interviews were conducted in five years to identify the conflicting parties, conflict types, coping strategies and resulting impact.FindingsLongitudinal qualitative data have revealed that female novice English language teaching (ELT) teachers mainly reported conflicts with their female colleagues. Goal, task and relationship conflict are the most common types of conflict encountered, while the strategies of avoiding, dominating and obliging are the most popular. This study also discusses the impacts of such conflict experiences.Originality/valueThis study identifies the influence of culture, particularly a culture of high power distance and an emphasis on “precious harmony”, on novice female teachers' conflict coping and offers insights into how conflict can be utilised to enhance novice teachers' professional development in the school professional learning community.
On whose side are you: perspective-taking and attribution of blame in handling sexual harassment complaints
Authors: Adikaram Arosha S. , Kailasapathy Pavithra 
Published: March 2023

PurposeThe authors aim to explore how perspective-taking and attribution of blame lead to side-taking by human resource professionals (HRPs) when making judgements and handling complaints of sexual harassment.Design/methodology/approachEmploying qualitative methodology, the authors used semi-structured in-depth interviews with 35 HRPs from 30 companies in Sri Lanka. Attribution theory and perspective-taking were used as theoretical lenses.FindingsIn handling complaints of sexual harassment incidents, HRPs take the perspectives of the alleged perpetrator, complainant, or the company and attribute the blame to the alleged perpetrator or the complainant. Irrespective of the gender of the HRPs and the perspective they take, they would most often blame the female complainants due to sexual harassment myths and misperceptions and traditional sex-role beliefs. Thus, they either take the side of the alleged perpetrator or the company, explicitly/implicitly or intentionally/unintentionally.Originality/valueThe central originality of this research is the finding that HRPs take sides in resolving complaints of sexual harassment and perspective-taking and attribution of blame by HRPs lead to this side-taking in organisational settings.
Next generation employability and career sustainability in the hospitality industry 5.0
Authors: Hussain Sarah , Singh Anubha Mahender , Mohanty Priyakrushna , Gavinolla Mahender Reddy 
Published: March 2023

PurposeWith an industry 5.0 revolution taking place in the hospitality industry, a shift from manual to cognitive labor is anticipated, characterized by greater sustainability, resilience and a human-centric approach. In this regard, hospitality educators' ability and willingness to teach novel topics such as automation at work, upskilling of employees, man-machine interaction and service robots have become more important than ever. This study aims to interpret the perspectives of hospitality educators about bridging the gap in the employability skills of (next-gen) hospitality graduates and the concerns relating to career sustainability in times of transition.Design/methodology/approachA case study method was used given the novelty of the topic in a developing country like India. A qualitative survey with open-ended questions, is employed to understand the viewpoints of Indian hospitality educators, including those with more than 15 years of teaching experience. In-depth interviews were conducted with 23 hospitality educators to reach the theoretical saturation point. MAXQDA software was used to analyze the qualitative data collected in the study.FindingsThe findings reveal the challenges and motivations of hospitality educators in adapting to frequently changing business environments. In doing so, it sheds light on the methods employed to create a generation of hospitality graduates aligned with the changing dynamics of the industry.Originality/valueThe paper presents the viewpoints of hospitality educators in India in relation to a futuristic approach to next-gen employability and career sustainability. Whilst numerous studies have focused on the role of robots and artificial intelligence in replacing the human component of the service environment, the concept of people working alongside advanced technologies is fairly new and needs to be fully explored.
Trophic interrelationships of bacteria are important for shaping soil protist communities
Authors: Nguyen Thi Bao Anh , Chen Qing‐Lin , Yan Zhen‐Zhen , Li Chaoyu , He Ji‐Zheng , Hu Hang‐Wei 
Published: March 2023

AbstractProtists occupy multiple trophic positions in soil food webs and significantly contribute to organic matter decomposition and biogeochemical cycling. Protists can ingest bacteria and fungi as main food sources while being subjected to predation of invertebrates, but our understanding of how bottom‐up and top‐down regulations structure protists in natural soil habitats is limited. Here, we disentangle the effects of trophic regulations to the diversity and structure of soil protists in natural settings across northern and eastern Australia. Bacterial and invertebrate diversity were identified as important drivers of the diversity of functional groups of protists. Moreover, the compositions of protistan taxonomic and functional groups were better predicted by bacteria and fungi, than by soil invertebrates. There were strong trophic interconnections between protists and bacteria in multiple organismic network analysis. Altogether, the study provided new evidence that, bottom‐up control of bacteria played an important role in shaping the soil protist community structure, which can be derived from feeding preferences of protists on microbial prey, and their intimate relationships in soil functioning or environmental adaptation. Our findings advance our knowledge about the impacts of different trophic groups on key soil organismic communities, with implications for ecosystem functions and services.
COVID‐19 and preeclampsia: The unique and the mutually nonexclusive clinical manifestations
Authors: Shetty Shrimati , Kshirsagar Shrinath , Bansal Shweta , Rangarajan Savita , Phadke Varsha 
Published: March 2023

AbstractPreeclampsia (PE) is a serious, unpredictable hypertensive disorder of pregnancy present in around 8–10% of all pregnancies resulting in high rate of maternal and fetal morbidity and mortality. With the pathophysiology partially known, delivery is the only cure for PE. The disease sets due to multiple pathologic processes involving endothelial cell activation, inflammation, multiorgan damage and syncytiotrophoblast stress. Though the primary target organ is lungs in COVID‐19, other systemic manifestations which include endothelial dysfunction, dysregulated angiogenesis, thrombosis, liver injury, thrombocytopenia, hypertension and kidney damage overlap with PE. COVID‐19 patients show a higher incidence of PE as compared to their noninfected counterparts and vice versa. Similar pathophysiology and clinical features make differential diagnosis challenging. For effective and specific management, it is important to differentiate actual PE from COVID‐19 with PE like features. There are contradictory reports about the accuracy of diagnostic tools in distinguishing PE from severe COVID‐19 with PE like features. With the available data, it can only be stated that PE is a common adverse pregnancy event, which may be exacerbated by, or may exacerbate, COVID‐19. Future research should focus on cohesive understanding of the pathophysiology of the clinical manifestations, and preventive strategies during pregnancy.
Globalization and Promissory Representation
Authors: Schneider Christina J. , Thomson Robert 
Published: March 2023

AbstractDespite the centrality of promise keeping to representation, we know little about how it is affected by economic globalization, which is one of the modern world's defining characteristics. We argue that globalization reduces governing parties' ability to keep their campaign promises. We test the empirical implications of our theory with a mixed‐methods approach that combines a large‐n quantitative comparative analysis of pledge fulfillment with a typical case study to trace the underlying causal mechanisms of the theory. The findings indicate that international economic integration exerts a large negative effect on the likelihood of pledge fulfillment in a broad range of contexts and that the hypothesized mechanisms are clearly observable in the detailed case study. These findings have important implications for democratic representation in a globalized world.
Covid‐19‐tested food labels
Authors: Shi Longzhong , Chen Xuan , Chen Bo 
Published: March 2023

AbstractWhile the transmission of virus SARS‐CoV‐2 via food is rare, some Chinese food retailers are considering a Covid‐19‐tested food label. However, how consumers may support such a label is unknown. We quantify Chinese consumers’ willingness to pay (WTP) for food carrying a Covid‐19‐tested label using an online choice experiment. We find that the WTPs for such a label are always positive for all food products considered. The amount of WTP depends on the entities authenticating the labels, country of origin of the food, and consumers’ socio‐demographic status. Contrary to expectation, the knowledge on Covid‐19 does not affect consumer preferences for the Covid‐19‐tested food labels. Our benefit and cost analysis suggests a possible large benefit of creating and administering a Covid‐19‐tested food label. This study provides insights for policymakers, global food manufacturers, and retailers to create marketing strategies to alleviate consumer food safety concerns associated with Covid‐19.
Prolonged diversion after ileal pouch‐anal anastomosis: Is it safe to wait?
Authors: Clancy Cillian , Connelly Tara M. , Jia Xue , Lipman Jeremy , Lightner Amy L. , Hull Tracy , Steele Scott R. , Holubar Stefan D. 
Published: March 2023

AbstractAimDiverting loop ileostomy reversal (DLI‐R) is routinely performed from 2–6 months following ileal pouch‐anal anastomosis (IPAA). The safety of delayed reversal after IPAA is not well‐defined. The aim of this study was to determine if prolonged diversion is associated with adverse outcomes compared to routine closure.MethodsAdult patients undergoing primary IPAA with DLI from 2000 to 2021 were included in this retrospective cohort study from our institutional database. Patients were stratified into tertiles based on timing of reversal: Routine (56–116 days), Delayed (117–180 days), or Prolonged (>6 months). Univariate analysis compared categorical variables between groups. Patients reversed at <8 weeks were excluded.ResultsIn total, 2615 patients underwent DLI‐R following IPAA (3‐stage 61%, 2‐stage 39%; mean age 39.9 years). DLI‐R was performed as Routine, Delayed and Prolonged in 1908 (72.9%), 426 (16.4%) and 281 (10.8%), respectively. Overall, DLI‐R related complications occurred in 12.4% (n = 324). The complication rate in the Routine group was 11% (n = 210), in the Delayed group was 12.2% (n = 52) and in the Prolonged group was 22.1% (n = 62). Reasons for prolonged diversion in the Prolonged group were complications at the time of IPAA in 207 (73.9%) or patient preference/scheduling in 73 (26.1%). DLI‐R >6 months after IPAA due to complications had higher rates of overall complications following ileostomy reversal (OR 2.6, 95% CI 1.85–3.72, p < 0.001) whereas when DLI‐R was delayed due to preference/scheduling outcomes were not different than the Routine group (p = 0.28).ConclusionProlonged time to ileostomy reversal after IPAA is probably safe without increased risk of complications when due to patient preference.