bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Broad-Spectrum Antibiotic De-escalation on Critically Ill Patient Outcomes: A Retrospective Cohort Study
Authors: Aldardeer Namareq , Qushmaq Ismael , AlShehail Bashayer , Ismail Nadia , AlHameed Abrar , Damfu Nader , Al Musawa Mohammad , Nadhreen Renad , Kalkatawi Bayader , Saber Bashaer , Nasser Mohannad , Ramdan Aiman , Thabit Abrar , Aldhaeefi Mohammed , Al Shukairi Abeer 
Published: June 2023

Abstract
Purpose
Antibiotic de-escalation (ADE) in critically ill patients is controversial. Previous studies mainly focused on mortality; however, data are lacking about superinfection. Therefore, we aimed to identify the impact of ADE versus continuation of therapy on superinfections rate and other outcomes in critically ill patients.

Methods
This was a two-center retrospective cohort study of adults initiated on broad-spectrum antibiotics in the intensive care unit (ICU) for ≥ 48 h. The primary outcome was the superinfection rate. Secondary outcomes included 30-day infection recurrence, ICU and hospital length of stay, and mortality.

Results
250 patients were included, 125 in each group (ADE group and continuation group). Broad spectrum antibiotic discontinuation occurred at a mean of 7.2 ± 5.2 days in the ADE arm vs. 10.3 ± 7.7 in the continuation arm (P value = 0.001). Superinfection was numerically lower in the ADE group (6.4% vs. 10.4%; P = 0.254), but the difference was not significant. Additionally, the ADE group had shorter days to infection recurrence (P = 0.045) but a longer hospital stay (26 (14–46) vs. 21 (10–36) days; P = 0.016) and a longer ICU stay (14 (6–23) vs. 8 (4–16) days; P = 0.002).

Conclusion
No significant differences were found in superinfection rates among ICU patients whose broad-spectrum antibiotics were de-escalated versus patients whose antibiotics were continued. Future research into the association between rapid diagnostics with antibiotic de-escalation in the setting of high resistance is warranted.
Analysing Dewey’s vocational aspects of education and Maslow’s theory of motivation in support of vocational education and training
Authors: Takyi Mensah Elijah , Chen Mingkun , Ntim Seth Yeboah , Gabrah Antoinette 
Published: June 2023

Abstract
Aim
The aim of this article is to analyse Dewey’s writing on vocational aspects of education in his book Democracy and Education: An introduction to the philosophy of education to identify and to relate the main philosophical ideas to Maslow’s theory of motivation and to establish the key similarities between the two theories to support contemporary Vocational Education and Training.
Concept.
The paper used content analysis to identify key themes from Dewey's vocational aspect of education and synthesised them with Maslow's theory of motivation. Based on both theories the article describes how motivation is critical in people’s pursuit of vocational career goals.

Result
The study identified source of livelihood, sustainable livelihood, social recognition, social contributions, academic, and career progression from Dewey’s vocational aspect of education as key ideas that are like Maslow’s physiological needs, safety needs, love and belonging needs, esteem needs, and self-actualization needs that influence people’s choice in vocational career goals.

Conclusion
We argue that if contemporary vocational education and training can be attractive to the young generation, the ideas expressed in Dewey’s vocational aspect of education and Maslow’s hierarchy of motivation should be considered by vocational education and training stakeholders when making vocational education career choice or goals.
Anatomical and molecular characterization of some rhigonematid parasites of millipedes in Nigeria, with new insights into their phylogeny
Authors: Fabiyi O.A. , Bello T.T. , Liébanas G. , Clavero-Camacho I. , Cantalapiedra-Navarrete C. , Archidona-Yuste A. , Palomares-Rius J.E. , Hunt D.J. , Castillo P. 
Published: June 2023

Abstract
Parasitic nematodes of millipedes from Nigeria are molecularly characterized for the first time. During nematode surveys on live giant African millipedes from several localities in Nigeria, 4 species of rhigonematids were identified by application of integrative taxonomical approaches (morpho-anatomy and molecular markers), including Brumptaemilius sp., Gilsonema gabonensis, Obainia pachnephorus, and Rhigonema disparovis. The results of morphometric and molecular analyses of D2-D3 28S, ITS, partial 18S rRNA, and cytochrome oxidase c subunit 1 (COI) gene sequences further characterized the rhigonematid species, and clearly separated them from other related species. Phylogenetic relationships based on 28S and 18S rRNA genes suggest that genera within Ransomnematoidea (Ransomnema, Heth, Carnoya, Brumptaemilius, Cattiena, Insulanema, Gilsonema) and Rhigonematoidea (Rhigonema, Obainia, Xystrognathus, Trachyglossoides, Ichthyocephaloides) clustered rather closer than could be expected in view of their morphological differences. Phylogenetic relationships based on ITS and COI are congruent with those of other ribosomal genes; however, they are not conclusive due to the scarcity of available sequences of these genes for these genera in NCBI.
Political regimes and firms' decisions to pay bribes: theory and evidence from firm-level surveys
Authors: Nishioka Shuichiro , Sharma Sumi , Le Tuan Viet 
Published: June 2023

AbstractThis paper makes the most of the observed actions of bribe takers and givers from the World Bank Enterprise Surveys and studies how a taker's action influences a giver's decision to pay bribes. To motivate our empirical study, we consider Kaufmann and Wei's (1999) Stackelberg game between a tax authority and a firm that undergoes tax inspection. The model predicts that, when the authority can use its action as a credible threat for the firm's profitability, the authority disturbs the firm by inspecting more, and the firm is more likely to pay bribes. Consistent with the theoretical prediction, we find correlational evidence that the propensity to pay bribes increases with the number of inspection visits, particularly for non-democratic countries.
Population-based cohort study of oral contraceptive use and risk of depression
Authors: Johansson T. , Vinther Larsen S. , Bui M. , Ek W. E. , Karlsson T. , Johansson Å. 
Published: June 2023

Abstract

Aim
Research on the effect of oral contraceptive (OC) use on the risk of depression shows inconsistent findings, especially in adult OC users. One possible reason for this inconsistency is the omission of women who discontinue OCs due to adverse mood effects, leading to healthy user bias. To address this issue, we aim to estimate the risk of depression that is associated with the initiation of OCs as well as the effect of OC use on lifetime risk of depression.

Methods
This is a population-based cohort study based on data from 264,557 women from the UK Biobank. Incidence of depression was addressed via interviews, inpatient hospital or primary care data. The hazard ratio (HR) between OC use and incident depression was estimated by multivariable Cox regression with OC use as a time-varying exposure. To validate causality, we examined familial confounding in 7,354 sibling pairs.

Results
We observed that the first 2 years of OC use were associated with a higher rate of depression compared to never users (HR = 1.71, 95% confidence interval [CI]: 1.55–1.88). Although the risk was not as pronounced beyond the first 2 years, ever OC use was still associated with an increased lifetime risk of depression (HR = 1.05, 95% CI: 1.01–1.09). Previous OC use were associated with a higher rate of depression compared to never users, with adolescent OC users driving the increased hazard (HR = 1.18, 95% CI: 1.12–1.25). No significant association were observed among adult OC users who had previously used OCs (HR = 1.00, 95% CI: 0.95–1.04). Notably, the sibling analysis provided further evidence for a causal effect of OC use on the risk of depression.

Conclusions
Our findings suggest that the use of OCs, particularly during the first 2 years, increases the risk of depression. Additionally, OC use during adolescence might increase the risk of depression later in life. Our results are consistent with a causal relationship between OC use and depression, as supported by the sibling analysis. This study highlights the importance of considering the healthy user bias as well as family-level confounding in studies of OC use and mental health outcomes. Physicians and patients should be aware of this potential risk when considering OCs, and individualized risk–benefit assessments should be conducted.
Komplementäre Therapien bei Depression
Authors: Kollak Ingrid 
Published: June 2023

Die häufig gestellte Diagnose Depression erfordert eine genauere Betrachtung
Dieses Buch stellt Menschen vor, die unter Depressionen leiden. Sie erleben Panikattacken, Trauer und Wut, Angst vor dem Altern, Alkoholabhängigkeit.
Die meisten Betroffenen bekommen Medikamente gegen ihre Depressionen. Ohne genauere Betrachtung der Lebensumstände, Gewohnheiten, Erlebnisse usw. nehmen sie Beruhigungstabletten und Schlafmittel, Antidepressiva und Johanniskraut und wollen schnell wieder gesund werden. So leicht geht das leider selten. Oft gibt es Nebenwirkungen, Depressionen wiederholen sich, eine Medikamentenabhängigkeit tritt auf, langwierige Entzugstherapien werden erforderlich.
Behandlungsleitlinien bewerten die Wirksamkeit von Psychotherapien als sehr hoch. Was Psychotherapien beinhalten, wie sie vorgehen und worauf sie abzielen, wird am Beispiel der Systemischen Therapie, Kognitiven Verhaltenstherapie, Tiefenpsychologischen Therapie, Klientenzentrierten Gesprächspsychotherapie und Familientherapie verdeutlicht.
Wie Betroffene aktiv ihre Behandlung gestalten können, um aus ihrer Depression herauszufinden, zeigen Beispiele aus der Entspannungs- und Körperarbeit, aus Tanz, Meditation und Psychoedukation, dem kreativen Schreiben, Übungsjournalen, Stimmungstagebüchern u.v.m.
Das Buch richtet sich an Fachleute aus der Ergo-, Physio-, Psychotherapie, Pflege und Medizin sowie an interessierte Betroffene und Angehörige. Es lädt ein, sich Standard- und komplementäre Therapien, wissenschaftliche Erkenntnisse und individuelle Erfahrungen anzusehen, um eigene Ansichten zu reflektieren und mehr Selbstsorge zu leben.

Aufbau und Inhalt
•Auslöser für Depressionen
•Krankheitserleben und Ursachenverständnis
•Standardtherapien, Studienergebnisse und Erfahrungsberichte
•Psychotherapien und ihre Vorgehensweisen
•Komplementäre Methoden in ihrer Vielfalt
Improving Surface Wave Retrieval From Traffic Noise by Deconvolution of the Decomposed Wavefield
Authors: Cao Weiping , Huang Xuri , Hu Yezheng , Xu Yungui , Tang Jing , Yao Hai 
Published: June 2023

AbstractTraffic noise is an important type of passive seismic data because it usually includes strong dispersive surface wave components and can be easily accessed. It can be used to extract virtual surface waves via seismic interferometry algorithms for the purpose of imaging subsurface shear wave velocity distribution. In this paper, we propose a scheme to improve the retrieval of surface waves from traffic noise recorded using linear arrays along traffic roads. By deconvolving the decomposed traffic noise wavefield, robust surface wave traces can be computed from a short noise record. First the far‐field component of the traffic noise recording is extracted and separated into unidirectionally propagating components. Then deconvolution interferometry is applied to these separated far‐field wavefield to extract surface wave Green's function. With this scheme, crosstalk noise and near‐field artifacts are excluded from the computation, and surface wave traces with high signal‐to‐noise ratio (SNR) are achieved using short traffic noise traces. In a synthetic test virtual surface waves estimated with the proposed method show significantly higher SNR than those computed with the conventional interferometry workflows, and matches well with simulated active source traces. A field data example with traffic noise recorded in a distributed acoustic sensing experiment also shows that surface waves estimated using the proposed methodology demonstrate higher SNR than those computed with the conventional interferometry schemes and that the virtual surface waves generated using 4 s of traffic noise demonstrate signal quality comparable to the surface waves recorded in this experiment with an active source.
Some Backscatter Modeling Issues Complicating the Sonar‐Based Monitoring of Suspended Sediments in Rivers
Authors: Vergne Adrien , Le Coz Jérôme , Berni Céline 
Published: June 2023

AbstractThe measurement of suspended sediments from acoustic backscatter was originally developed in marine science for monitoring near‐bottom suspensions usually composed of sand particles. In the last decade, there has been a growing interest in adapting these techniques to rivers. The so‐called “solid particle theory” developed in oceanography mainly applies to suspensions of non‐cohesive solid particles producing incoherent backscatter signal. So far, this theory has been used for interpreting river backscatter even if it relies on assumptions that are not obviously met in rivers. This study uses a set of measurements made on the Rhône River in France to discuss the typical issues which challenge the interpretation of sound backscattering for monitoring suspended sediments in rivers. Large discrepancies between model outputs and measurements for frequencies lower than 2.5 MHz suggest that other scattering processes including flocculation and air micro‐bubbles may have a large impact on acoustic backscatter and attenuation. Deviations of the backscatter echo distribution from Rayleigh statistics were observed, suggesting that the assumption of incoherent backscattering is not always met. This work calls for the development of a more complete theory for interpreting river backscatter.
Forecasting >300 MeV SEP Events: Extending SPARX to High Energies
Authors: Waterfall C. O. G. , Dalla S. , Marsh M. S. , Laitinen T. , Hutchinson A. 
Published: June 2023

AbstractThe forecasting of solar energetic particles (SEPs) is a prominent area of space weather research. Numerous forecasting models exist that predict SEP event properties at proton energies <100 MeV. One of these models is the Solar Particle Radiation SWx (SPARX) system, a physics‐based forecasting tool that calculates >10 and >60 MeV flux profiles within minutes of a flare being detected. This work describes SPARX−H, the extension of SPARX to forecast SEP events above 300 MeV. SPARX−H predicts fluxes in three high energy channels up to several 100 MeV. Correlations between SEP peak flux and peak intensity of the associated solar flare are seen to be weak at high energies, but improved when events are grouped based on the field polarity during the event. Initial results from this new high energy forecasting tool are presented here and the applications of high energy forecasts are discussed. Additionally, the new high energy version of SPARX is tested on a set of historic SEP events. We see that SPARX−H performs best when predicting peak fluxes from events with source locations in well‐connected regions, where many large SEP events tend to originate.
α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis
Authors: Cai Yiqing , Lv Liemei , Lu Tiange , Ding Mengfei , Yu Zhuoya , Chen Xiaomin , Zhou Xiangxiang , Wang Xin 
Published: June 2023

AbstractMetabolic reprogramming is a hallmark of human malignancies. Dysregulation of glutamine metabolism is essential for tumorigenesis, microenvironment remodeling, and therapeutic resistance. Based on the untargeted metabolomics sequencing, we identified that the glutamine metabolic pathway was up-regulated in the serum of patients with primary DLBCL. High levels of glutamine were associated with inferior clinical outcomes, indicative of the prognostic value of glutamine in DLBCL. In contrast, the derivate of glutamine alpha-ketoglutarate (α-KG) was negatively correlated with the invasiveness features of DLBCL patients. Further, we found that treatment with the cell-permeable derivative of α-KG, known as DM-αKG, significantly suppressed tumor growth by inducing apoptosis and non-apoptotic cell death. Accumulation of a-KG promoted oxidative stress in double-hit lymphoma (DHL), which depended on malate dehydrogenase 1 (MDH1)-mediated 2-hydroxyglutarate (2-HG) conversion. High levels of reactive oxygen species (ROS) contributed to ferroptosis induction by promoting lipid peroxidation and TP53 activation. In particular, TP53 overexpression derived from oxidative DNA damage, further leading to the activation of ferroptosis-related pathways. Our study demonstrated the importance of glutamine metabolism in DLBCL progression and highlighted the potential application of α-KG as a novel therapeutic strategy for DHL patients.
Oculofaciocardiodental syndrome caused by a novel BCOR variant
Authors: Yamashita Tomoyo , Hotta Junko , Jogu Yukiko , Sakai Eri , Ono Chie , Bamba Haruka , Suzuki Hisato , Yamada Mamiko , Takenouchi Toshiki , Kosaki Kenjiro , Yorifuji Tohru , Hamazaki Takashi , Seto Toshiyuki 
Published: June 2023

AbstractOculofaciocardiodental syndrome is caused by variants in the BCL6 corepressor (BCOR) gene. We identified a novel heterozygous frameshift variant, NM_001123385.2(BCOR):c.2326del, that arose de novo in a Japanese girl with characteristic facial features, congenital heart disease, bilateral syndactyly of toes 2 and 3, congenital cataracts, dental abnormalities, and mild intellectual disability. Reports of BCOR variants are rare, and further case accumulation is warranted.
Tailoring magnetic hysteresis of additive manufactured Fe-Ni permalloy via multiphysics-multiscale simulations of process-property relationships
Authors: Yang Yangyiwei , Oyedeji Timileyin David , Zhou Xiandong , Albe Karsten , Xu Bai-Xiang 
Published: June 2023

AbstractDesigning the microstructure of Fe-Ni permalloy produced by additive manufacturing (AM) opens new avenues to tailor its magnetic properties. Yet, AM-produced parts suffer from spatially inhomogeneous thermal-mechanical and magnetic responses, which are less investigated in terms of process modeling and simulations. We present a powder-resolved multiphysics-multiscale simulation scheme for describing magnetic hysteresis in AM-produced material, explicitly considering the coupled thermal-structural evolution with associated thermo-elasto-plastic behaviors and chemical order-disorder transitions. The residual stress is identified as the key thread in connecting the physical processes and phenomena across scales. By employing this scheme, we investigate the dependence of the fusion zone size, the residual stress and plastic strain, and the magnetic hysteresis of AM-produced Fe21.5Ni78.5on beam power and scan speed. Simulation results also suggest a phenomenological relation between magnetic coercivity and average residual stress, which can guide the magnetic hysteresis design of soft magnetic materials by choosing appropriate processing parameters.
The roles of theaflavins in reducing dentin erosion
Authors: Guo Jing , Yang Mingqi , Hu Mengna 
Published: June 2023

AbstractThis study aimed to evaluate the effect of theaflavins [TFs] on the process of dentin erosion and investigation the potential mechanism. For erosion kinetics of the dentin, 7 experimental groups (n = 5) treated with 10% ethanol [EtOH] (negative control) are erosion for 1, 2, 3, 4, 5, 6, and 7 d erosion cycles (4 cycles/d). For the effect of TFs on dentin erosion, 6 experimental groups (n = 5) were treated with 1% epigallocatechin gallate [EGCG], 1% chlorhexidine [CHX], 1%, 2%, 4%, and 8% TFs for the 30 s and then subjected to erosion cycles (4 cycles/d for 7 d). The erosive dentin wear (μm) and surface morphology were evaluated and compared by laser scanning confocal microscope and scanning electron microscopy. The matrix metalloproteinase inhibition effects of TFs were investigated using in situ zymography and molecular docking. TFs-treated collagen was investigated by ultimate microtensile strength, Fourier-transform infrared spectroscopy, and molecular docking. Data were analyzed by ANOVA, Tukey’s test (P < 0.05). The TFs-treated groups (7.56 ± 0.39, 5.29 ± 0.61, 3.28 ± 0.33, and 2.62 ± 0.99 μm for 1%, 2%, 4%, and 8% TFs) had significantly lower erosive dentin wear than the negative control group (11.23 ± 0.82 μm), and the effect was concentration-dependent at low concentrations (P < 0.05). TFs inhibit matrix metalloproteinase [MMP]. Moreover, TFs crosslink dentin collagen and cause hydrophilic changes in dentin collagen. TFs preserve organic matrix within the demineralized dentin by inhibiting MMP activity and simultaneously improving collagen’s resistance to enzymes, both of which contribute to preventing or slowing down the progression of dentin erosion.
Bone aerophones from Eynan-Mallaha (Israel) indicate imitation of raptor calls by the last hunter-gatherers in the Levant
Authors: Davin Laurent , Tejero José-Miguel , Simmons Tal , Shaham Dana , Borvon Aurélia , Tourny Olivier , Bridault Anne , Rabinovich Rivka , Sindel Marion , Khalaily Hamudi , Valla François 
Published: June 2023

AbstractDirect evidence for Palaeolithic sound-making instruments is relatively rare, with only a few examples recorded from Upper Palaeolithic contexts, particularly in European cultures. However, theoretical considerations suggest that such artefacts have existed elsewhere in the world. Nevertheless, evidence for sound production is tenuous in the prehistoric archaeological record of the Levant, the study of music and its evolution being sparsely explored. Here we report new evidence for Palaeolithic sound-making instruments from the Levant with the discovery of seven aerophones made of perforated bird bones in the Final Natufian site of Eynan-Mallaha, Northern Israel. Through technological, use-wear, taphonomic, experimental and acoustical analyses, we demonstrate that these objects were intentionally manufactured more than 12,000 years ago to produce a range of sounds similar to raptor calls and whose purposes could be at the crossroads of communication, attracting hunting prey and music-making. Although similar aerophones are documented in later archaeological cultures, such artificial bird sounds were yet to be reported from Palaeolithic context. Therefore, the discovery from Eynan-Mallaha contributes new evidence for a distinctive sound-making instrument in the Palaeolithic. Through a combined multidisciplinary approach, our study provides important new data regarding the antiquity and development of the variety of sound-making instruments in the Palaeolithic at large and particularly at the dawn of the Neolithic in the Levant.