bluuebunny/crossref_metadata_2025_split huggingface dataset:
PTTG1 Reprograms Asparagine Metabolism to Promote Hepatocellular Carcinoma Progression
Authors: Zhou Qi , Li Leijia , Sha Feifei , Lei Yiming , Tian Xuan , Chen Lingjun , Chen Yan , Liu Huiling , Guo Yunwei 
Published: May 2023

Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a poor prognosis. Pituitary tumor transforming gene 1 (PTTG1) is highly expressed in HCC, suggesting it could play an important role in hepatocellular carcinogenesis. Here, we evaluated the impact of PTTG1 deficiency on HCC development using a diethylnitrosamine (DEN)-induced HCC mouse model and a hepatitis B virus (HBV) regulatory X protein (HBx)–induced spontaneous HCC mouse model. PTTG1 deficiency significantly suppressed DEN- and HBx-induced hepatocellular carcinogenesis. Mechanistically, PTTG1 promoted asparagine synthetase (ASNS) transcription by binding to its promoter, and asparagine (Asn) levels were correspondingly increased. The elevated levels of Asn subsequently activated the mTOR pathway to facilitate HCC progression. In addition, asparaginase treatment reversed the proliferation induced by PTTG1 overexpression. Furthermore, HBx promoted ASNS and Asn metabolism by upregulating PTTG1 expression. Overall, PTTG1 is involved in the reprogramming of Asn metabolism to promote HCC progression and may serve as a therapeutic and diagnostic target for HCC.

Significance:
PTTG1 is upregulated in hepatocellular carcinoma and increases asparagine production to stimulate mTOR activity and promote tumor progression.
Medical Financial Hardship and Food Security among Cancer Survivors in the United States
Authors: Hallgren Emily , Narcisse Marie-Rachelle , Andersen Jennifer A. , Willis Don E. , Thompson Tess , Bryant-Smith Gwendolyn , McElfish Pearl A. 
Published: May 2023

Abstract

Background:
Some cancer survivors experience medical financial hardship, which may reduce their food security. The purpose of this study was to explore whether medical financial hardship is related to food security among cancer survivors.

Methods:
The study was based on cross-sectional data from the 2020 National Health Interview Survey. We used ordinal logistic regression to examine the relationship between material, psychological, and behavioral medical financial hardships and household food security (i.e., high, marginal, low, or very low) among individuals ages ≥18 years who reported a cancer diagnosis from a health professional (N = 4,130).

Results:
The majority of the sample reported high household food security (88.5%), with 4.8% reporting marginal, 3.6% reporting low, and 3.1% reporting very low household food security. In the adjusted model, the odds of being in a lower food security category were higher for cancer survivors who had problems paying or were unable to pay their medical bills compared with those who did not [OR, 1.73; 95% confidence interval (CI), 1.06–2.82, P = 0.027], who were very worried about paying their medical bills compared with those who were not at all worried (OR, 2.88; 95% CI, 1.64–5.07; P &lt; 0.001), and who delayed medical care due to cost compared with those who did not (OR, 2.56; 95% CI, 1.29–5.09; P = 0.007).

Conclusions:
Food insecurity is rare among cancer survivors. However, medical financial hardship is associated with an increased risk of lower household food security among cancer survivors.

Impact:
A minority of cancer survivors experience medical financial hardship and food insecurity; social needs screenings should be conducted.
Cancer InFocus: Tools for Cancer Center Catchment Area Geographic Data Collection and Visualization
Authors: Burus Justin Todd , Park Lee , McAfee Caree R. , Wilhite Natalie P. , Hull Pamela C. 
Published: May 2023

Abstract

Background:
The NCI added Community Outreach and Engagement (COE) requirements for NCI-designated cancer centers in 2017, including the charge of characterizing the cancer burden in the geographic area served by their center (i.e., catchment area). Doing so helps cancer centers better identify needs and areas of inequality in their populations to guide research and outreach. To accomplish this, current and comprehensive data must be gathered from multiple sources and analyzed by the COE—a task that is tedious and inefficient. In this paper we present an efficient solution, known as Cancer InFocus, to collecting and visualizing quantitative data that we have generalized for use by other cancer centers on their catchment areas.

Methods:
Cancer InFocus utilizes open source programming languages and modern data collection techniques to gather and transform publicly-available data from various sources for use in specific geographic contexts.

Results:
Cancer InFocus delivers a choice of two routes for creating interactive online mapping applications that visualize cancer incidence and mortality rates, along with relevant social determinant and risk factor variables, at various geographic levels for a defined cancer center catchment area.

Conclusions:
Generalized software has been produced to collect and visualize data on any set of U.S. counties, which can be automated to continue providing the most up-to-date data.

Impact:
Cancer InFocus provides tools for cancer centers to accomplish the critical task of maintaining current and comprehensive catchment area data. The open source format will facilitate future enhancements through user collaboration.
Taming Glioblastoma in “Real Time”: Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology
Authors: de Godoy Laiz Laura , Chawla Sanjeev , Brem Steven , Mohan Suyash 
Published: May 2023

Abstract
The highly aggressive nature of glioblastoma carries a dismal prognosis despite aggressive multimodal therapy. Alternative treatment regimens, such as immunotherapies, are known to intensify the inflammatory response in the treatment field. Follow-up imaging in these scenarios often mimics disease progression on conventional MRI, making accurate evaluation extremely challenging. To this end, revised criteria for assessment of treatment response in high-grade gliomas were successfully proposed by the RANO Working Group to distinguish pseudoprogression from true progression, with intrinsic constraints related to the postcontrast T1-weighted MRI sequence. To address these existing limitations, our group proposes a more objective and quantifiable “treatment agnostic” model, integrating into the RANO criteria advanced multimodal neuroimaging techniques, such as diffusion tensor imaging (DTI), dynamic susceptibility contrast-perfusion weighted imaging (DSC-PWI), dynamic contrast enhanced (DCE)-MRI, MR spectroscopy, and amino acid-based positron emission tomography (PET) imaging tracers, along with artificial intelligence (AI) tools (radiomics, radiogenomics, and radiopathomics) and molecular information to address this complex issue of treatment-related changes versus tumor progression in “real-time”, particularly in the early posttreatment window. Our perspective delineates the potential of incorporating multimodal neuroimaging techniques to improve consistency and automation for the assessment of early treatment response in neuro-oncology.
Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies
Authors: Luke Jason J. , Piha-Paul Sarina A. , Medina Theresa , Verschraegen Claire F. , Varterasian Mary , Brennan Aoife M. , Riese Richard J. , Sokolovska Anna , Strauss James , Hava David L. , Janku Filip 
Published: May 2023

Abstract

Purpose:
SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle 1917 (EcN) engineered to produce cyclic dinucleotides under hypoxia, leading to STimulator of INterferon Genes (STING) activation in phagocytic antigen-presenting cells in tumors and activating complementary innate immune pathways.

Patients and Methods:
This first-in-human study (NCT04167137) enrolled participants with refractory advanced cancers to receive repeat intratumoral injections of SYNB1891 either alone or in combination with atezolizumab, with the primary objective of evaluating the safety and tolerability of both regimens.

Results:
Twenty-four participants received monotherapy across six cohorts, and 8 participants received combination therapy in two cohorts. Five cytokine release syndrome events occurred with monotherapy, including one that met the criteria for dose-limiting toxicity at the highest dose; no other SYNB1891-related serious adverse events occurred, and no SYNB1891-related infections were observed. SYNB1891 was not detected in the blood at 6 or 24 hours after the first intratumoral dose or in tumor tissue 7 days following the first dose. Treatment with SYNB1891 resulted in activation of the STING pathway and target engagement as assessed by upregulation of IFN-stimulated genes, chemokines/cytokines, and T-cell response genes in core biopsies obtained predose and 7 days following the third weekly dose. In addition, a dose-related increase in serum cytokines was observed, as well as stable disease in 4 participants refractory to prior PD-1/L1 antibodies.

Conclusions:
Repeat intratumoral injection of SYNB1891 as monotherapy and in combination with atezolizumab was safe and well tolerated, and evidence of STING pathway target engagement was observed.
“Nenhum lugar é um deserto”: Dois museus de Álvaro Siza
Authors: Moreira Fernando Diniz , Medeiros Julia Silva de 
Published: May 2023

Ancorado em uma abordagem fenomenológica da arquitetura, este artigo analisa dois museus projetados por Álvaro Siza, buscando explicitar como estratégias projetuais podem contribuir positivamente para a relação entre os museus contemporâneos e a cidade. Siza foi escolhido pela sensível e criteriosa maneira que insere seus edifícios em situações urbanas complexas que articulam tecidos históricos, paisagens naturais e vestígios antigos de ocupação humana. A análise busca revelar como esses museus adquirem significado pela maneira como experienciamos seus espaços, através do arranjo de percursos, do manejo da luz, materiais e processos construtivos e da relação estabelecida com o sítio, a topografia e o território.
Diffusion-Derived Vessel Density Computed From a Simplified Intravoxel Incoherent Motion Imaging Protocol in Pregnancies Complicated by Early Preeclampsia: A Novel Biomarker of Placental Dysfunction
Authors: He Junshen , Chen Chunlin , Xu Liqun , Xiao Benheng , Chen Zhao , Wen Ting , Wáng Yì Xiáng J. , Liu Ping 
Published: May 2023

BACKGROUND:
Early preeclampsia is associated with significant placental hypoperfusion. We explore the diagnostic value of placental diffusion-derived vessel density (DDVD), a biomarker derived from diffusion-weighted magnetic resonance imaging, which measures in vivo vessel microperfusion, in the differential diagnosis of normal and early preeclampsia pregnancies.

METHODS:

This was a prospective study involving 29 controls and 17 singleton pregnancies affected by early preeclampsia. Nineteen pregnancies from 28 to 34 weeks of gestational age were included from the normal group for a comparison with the early preeclampsia group. Using a 3.0 T magnetic resonance imaging scanner, diffusion-weighted images were obtained with the diffusion weighting
b
values of 0, 20, and 40 s/mm
2
. DDVD
mean
was the mean of DDVD
b0b20
and DDVD
b0b40
, while DDVD
b0b20
and DDVD
b0b40
refer to the diffusion-derived vessel density values computed from
b
=0 and 20 s/mm
2
images, and from
b
=0 and 40 s/mm
2
images, respectively. The correlation between DDVD
mean
and gestational age was examined using a linear regression model. The area under the curve of the DDVD
mean
for early preeclampsia pregnancies detection was calculated by the receiver operating characteristic analysis.

RESULTS:

As gestational age increased, DDVD
mean
linearly decreased. DDVD
mean
was significantly decreased in the early preeclampsia pregnancies compared with the normal pregnancies (52.72±46.73 versus 213.34±93.50 au/pixel;
P
<0.001). The area under the curve (DDVD
mean
) for discriminating between normal and early preeclampsia pregnancies regardless of fetal growth restriction was 0.954, and the area under the curve was 1.000 when early preeclampsia pregnancies without fetal growth restriction were excluded.

CONCLUSIONS:

DDVD
mean
, an in vivo vessel microperfusion measure, allowed total separation of normal and early preeclampsia pregnancies.
Ibn ʿ⁠Arabī on the Circle of Trusteeship and the Divine Name al-Wakīl
Authors: Khalil Atif 
Published: May 2023

Abstract
With special reference to chapters 119 and 558 of the Meccan Revelations, the article draws out Ibn ʿ⁠Arabī’s (d. 638/1240) understanding of the divine Name al-Wakīl (“The Trustee”) and the nature of trusteeship (wakāla). In the process, it demonstrates how for our mystic trusteeship forms a circle that begins with the human being entrusting his affairs to God, and returns to its point of origin with God entrusting him to be His vicegerent (khalīfa). Trusteeship, which finds its archetypical perfection in the divine Wakīl, descends through various degrees of perfection, to all levels and strata of human society. The capacity to embody and manifest the Name al-Wakīl is, for Ibn ʿ⁠Arabī, itself made possible by the theomorphic nature of the human being, a child of the primordial Adam fashioned in the image of God.
From the Cross to the Pyre: The Representation of the Martyrs of Japan in Jesuit Prints
Authors: Rappo Hitomi Omata 
Published: May 2023

Abstract
The iconography of the martyrs of Japan is often linked to that of the Twenty-Six Martyrs of Nagasaki. This group of mostly Franciscans was crucified in 1597 and beatified in 1627, and also included three Jesuits. The Society of Jesus, however, did not emphasize these martyrs in their engravings and representations of the victims of their Japanese mission especially before their beatification. The close study of two major works, Nicolas Trigault’s History of the Martyrs of Japan (Latin, 1623; French, 1624) and the famous Imago primi saeculi (1640), reveals how text and image combine to generate a different discourse of martyrdom that centered on sacrificial fire rather than death on the cross. Although the first three beatified martyrs were never forgotten, the Imago in particular foregrounds another Jesuit martyr, Carlo Spinola, whose prominent family had played an important role in that work’s creation.
“To have a printer at hand”: Jesuits and the Dissemination of Printing in the Polish-Lithuanian Commonwealth before 1620
Authors: Komorowska Magdalena 
Published: May 2023

Abstract
In the second half of the sixteenth century, the Jesuits considered the Polish–Lithuanian Commonwealth a missionary territory. This perception was linked to the exceptional writing and publishing activity. The Jesuits not only had about seven hundred editions of their writings published before 1620, they also established their own printing presses. This article identifies the main purposes of Jesuit publishing activity, demonstrates the Society’s proficiency with various printed media and reflects on their role in the dissemination of printing craft throughout the Commonwealth.
Severe tracheal tear – an alternative extracorporeal membrane oxygenation indication
Authors: Buschulte Katharina , Kahn Nicolas , Schmidt Werner , Reinhardt Lars 
Published: May 2023

Introduction Conservative management is usually preferred for iatrogenic tracheal injuries. Venovenous extracorporeal membrane oxygenation (V-V ECMO) is mostly used in acute refractory hypoxemia, airway lesions are an alternative indication. Case Report A 51-year-old female was transferred with a large tracheal tear after plastic tracheotomy. Due to a critical ventilation situation with hypercapnia, conservative management was set and V-V ECMO was installed. With optimized tube positioning, minimal ventilation and gas transfer via V-V ECMO, a complete healing of the injury could be achieved. Discussion Fast diagnosis of tracheal injuries is essential; transfer to a specialized centre should be considered. In our case, organ support via ECMO was necessary due to a difficult ventilation situation with persisting hypercapnia. Thus, reduction in ventilation pressures with reduction of possible leakage and healing of the tracheal tear could be achieved. Conclusion Management of tracheal tears is complex; in severe cases special therapy concepts such as the use of V-V ECMO may become necessary.
Evaluation of Unbiased Opinions Related to Orthodontic Treatment Decision-Making Using a Simplified Malocclusion Index: A Cross Sectional Study Within Two Tribal Populations With No Prior Treatment History
Authors: Digumarthi Uday Kumar , Prakash Ram 
Published: May 2023

Background An analysis of the factors influencing the decision-making process in accepting orthodontic treatment can be of profound importance in establishing trust and ensuring an overall positive outcome. This is all the more significant when dealing with a patient who has not had any prior interaction with an orthodontist. The Simplified Malocclusion Index for Layperson Evaluation (SMILE Index) allows an unbiased cross-evaluation between the perceived need for treatment and the factors of orthodontic awareness and self-perceived esthetics. Objectives Tribal adolescents belonging to 2 regions with no prior access to orthodontic treatment were chosen for the study. Most adolescents of this region were assumed to have orthodontic awareness by way of information from their schools and dental camps. During the orthodontic screening process, a verbally assigned questionnaire base index was used to elicit their willingness to undergo treatment and to understand influencing factors. Methods A total of 2,835 tribal adolescents between the ages of 13 and 19 years belonging to the Revenue divisions of Paderu (Visakhapatnam) and Parvathipuram (Vizianagaram) were screened in this study. Chosen candidates presented with normal growth and development, and had no nutritional deficiencies or metabolic disorders. Consent and permissions were obtained from the regional tribal authorities, institutional ethical clearance committee, the school authorities, and the parents or guardians of the adolescents. The orthodontic screening was performed under natural daylight with strict adherence to infection prevention protocol. Observed occlusions were categorized into either an ideal occlusion or Angle’s Class I, II, and III malocclusions. During the screening, the SMILE index was assigned in the vernacular Telugu. A percentage distribution analysis was made of the responses of those presenting with malocclusion. Results An analysis of the SMILE index results of the adolescents of Paderu Revenue division revealed higher SMILE index scores in categories III and V with a percentage distribution of 24.46% for males and 26.86% for females in SMILE Index Score Category III and 63.40% for the males and 52.13% for the females in Category V. Similarly, the results of Parvathipuram division had a higher score distribution in the categories of III and V with a percentage distribution of 16.07% for males and 15.84% for females in category III and 78.67% for males and 74.25% for females in category V. Conclusion Orthodontic treatment with proper counseling providing clarity of facts facilitates an easier decision-making process and enables both the patient and the orthodontist to understand one another and the treatment process better for a much more predictable overall treatment outcome.
Association Between Growth Hormone Receptor Gene Polymorphisms rs6180, rs6182, and rs6184 and Craniofacial Parameters in Indian Population
Authors: Sameemullah Kathijathul Hidhaya , Tripathi Tulika , Polipalli Sunil Kumar , Kalra Shilpa , Rai Priyank , Kanase Anup 
Published: May 2023

Objective/Background Craniofacial growth and development is influenced by growth hormone, which is in turn facilitated by the growth hormone receptor (GHR). GHR gene polymorphisms have been found to be associated with mandibular morphology and skeletal facial profiles in various populations. The aim of this study was to determine the association of single nucleotide polymorphisms (SNP) of GHR gene rs6180, rs6182, and rs6184 with maxillomandibular parameters in the Indian population. Setting and Sample Population A cross sectional study was conducted on 174 male and female Indian subjects in the age range of 20 to 32 years who reported for orthodontic treatment. Material and Methods Venous blood and lateral cephalogram were collected from each participant for genetic and cephalometric analysis. Genotypes of each SNP were identified by polymerase chain reaction—restriction fragment length polymorphism. Independent t test and Analysis of Variance (ANOVA) were done for intra and inter group comparisons with SPSS software. Results SNPs rs6180, and rs6182 were found to be associated with sagittal position and length of maxilla and mandible, anterior facial height, and growth pattern. SNP rs6184 did not have any significant association with the craniofacial parameters. Conclusion The results suggest that the GHR gene might be a candidate gene for maxillomandibular morphology in the Indian population.
Geriatric Psychiatrists’ Perspectives on Palliative Care: Results From A National Survey
Authors: Elhassan Hana , Robbins-Welty Gregg A. , Moxley Jerad , Reid M. Carrington , Shalev Daniel 
Published: May 2023

Objectives Older adults with psychiatric illnesses often have medical comorbidities that require symptom management and impact prognosis. Geriatric psychiatrists are uniquely positioned to meet the palliative care needs of such patients. This study aims to characterize palliative care needs of geriatric psychiatry patients and utilization of primary palliative care skills and subspecialty referral among geriatric psychiatrists. Methods National, cross-sectional survey study of geriatrics psychiatrists in the United States. Results Respondents (n = 397) reported high palliative care needs among their patients (46-73% of patients). Respondents reported using all domains of palliative care in their clinical practice with varied comfort. In multivariate modeling, only frequency of skill use predicted comfort with skills. Respondents identified that a third of patients would benefit from referral to specialty palliative care. Conclusions Geriatric psychiatrists identify high palliative care needs in their patients. They meet these needs by utilizing primary palliative care skills and when available referral to subspecialty palliative care.