bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rewindable Quantum Computation and Its Equivalence to Cloning and Adaptive Postselection
Authors: Hiromasa Ryo , Mizutani Akihiro , Takeuchi Yuki , Tani Seiichiro 
Published: January 2025

Abstract
We define rewinding operators that invert quantum measurements. Then, we define complexity classes

$$\textsf{RwBQP}$$

RwBQP

,

$$\textsf{CBQP}$$

CBQP

, and

$$\textsf{AdPostBQP}$$

AdPostBQP

as sets of decision problems solvable by polynomial-size quantum circuits with a polynomial number of rewinding operators, cloning operators, and adaptive postselections, respectively. Our main result is that

$$\textsf{BPP}^\textsf{PP}\subseteq \textsf{RwBQP}=\textsf{CBQP}=\textsf{AdPostBQP}\subseteq \textsf{PSPACE}$$

BPP
PP

⊆
RwBQP
=
CBQP
=
AdPostBQP
⊆
PSPACE

. As a byproduct of this result, we show that any problem in

$$\textsf{PostBQP}$$

PostBQP

can be solved with only postselections of events that occur with probabilities polynomially close to one. Under the strongly believed assumption that

$$\textsf{BQP}\nsupseteq \textsf{SZK}$$

BQP
⊉
SZK

, or the shortest independent vectors problem cannot be efficiently solved with quantum computers, we also show that a single rewinding operator is sufficient to achieve tasks that are intractable for quantum computation. Finally, we show that rewindable Clifford circuits remain classically simulatable, but rewindable instantaneous quantum polynomial time circuits can solve any problem in

$$\textsf{PP}$$

PP

.
Multifocal osteochondromatous proliferation and paraneoplastic hematologic dyscrasia in the context of latent Epstein-Barr virus reactivation: a case of oncologic and infectious pathophysiology
Authors: Khalil Zeyad Hossam Atta , Osman Taha Ali 
Published: January 2025

Abstract
This case report describes a 15-year-old male with multifocal osteochondromatous proliferation and paraneoplastic hematologic dyscrasia, linked to latent Epstein-Barr virus reactivation. Radiographic and advanced imaging revealed widespread skeletal lesions consistent with osteochondromatosis. Hematologic evaluation indicated pancytopenia with dysplastic megakaryocytes and marrow infiltration. Immunohistochemical staining confirmed latent Epstein-Barr virus infection, suggesting its role in the pathogenesis of both the osteochondromatous and hematologic abnormalities. This case highlights the correlation between Epstein-Barr virus reactivation, bone proliferation, and paraneoplastic hematologic processes, which we believe has not yet been reported in the literature, emphasizing the need for a comprehensive diagnostic approach.
Integrated care for multi-domain vulnerability during pregnancy: a retrospective cohort study
Authors: Munshi Sushma C. , Hoex Eline C. I. , Weggelaar-Jansen Anne Marie , Knijff Esther M. , van der Wilk Eline C. , Steegers Eric A. P. , Bijma Hilmar H. 
Published: January 2025

Abstract

Purpose
Psychosocial risk factors are frequently present in pregnant women and are associated with adverse maternal and neonatal outcomes. Professional guidelines recommend early detection of vulnerability and provision of multidisciplinary care, including an integrated care plan for pregnant women with social factors, such as residing in deprived areas, teenage pregnancy, and psychiatric illness. However, to date, such approach is impeded by lack of data on co-occurrence of vulnerability. Therefore, we aim to describe co-occurrence of psychiatric illness, social factors or substance use during pregnancy.

Methods
A retrospective cohort study of 1002 pregnant women referred for evaluation by a multidisciplinary team because of psychiatric illness, social factors or substance use in a university hospital in a large city in the Netherlands. Data from medical charts between January 2017 and May 2022 were extracted and analyzed by univariate and bivariate analysis.

Results
Multi-domain vulnerability was present in 83% of women and most frequently involved the following patterns: psychiatric illness with social factors and chronic physical illness (24%), psychiatric illness with social factors (14%), social factors with chronic physical illness (13%) and psychiatric illness with chronic physical illness (12%). Single-domain vulnerability was present in 17% of women, involving most frequently social factors (9%) and psychiatric illness (8%).

Conclusion
The majority of women with psychiatric illness, social factors or substance use have multi-domain vulnerability. There is a need for a novel approach to care to address vulnerability in pregnant women.
Advancements in gene therapies targeting mutant KRAS in cancers
Authors: Wang Yuhang , Bui Thuy Anh , Yang Xinpu , Hutvagner Gyorgy , Deng Wei 
Published: January 2025

Abstract
Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically, these mutations promote uncontrolled cell proliferation and alter the tumour microenvironment during early carcinoma stages. Given their critical carcinogenic functions, significant progress has been made in developing KRAS inhibitors for cancer treatment. However, clinical applications of these KRAS inhibitor compounds are limited to specific cancer types which carry the relevant KRAS mutations. Additionally, clinical findings have shown that these compounds can induce moderate to serious side effects. Therefore, new approaches have emerged focusing on the development of universal therapeutics capable of targeting a wider range of KRAS mutations, minimising toxicity and enhancing the therapeutic efficacy. This review aims to examine these therapeutic strategies in the context of cancer treatment. It firstly provides an overview of fundamental KRAS biology within the cell signalling landscape and how KRAS mutations are associated with cancer pathogenesis. Subsequently, it introduces the development of current KRAS inhibitors which target certain KRAS mutants in different types of cancer. It then explores the potential of gene therapy approaches, including siRNA, miRNA and CRISPR methodologies. Furthermore, it discusses the use of lipid-based nanocarriers to deliver gene cargos for targeting KRAS gene mutants. Finally, it provides the insights into the future prospects for combatting KRAS mutation-associated cancers.

Graphical Abstract
Inefficient incentives for energy saving in tenancy law and policy options to remedy the landlord-tenant dilemma
Authors: Reutter Leo 
Published: January 2025

Abstract
The rental building sector faces challenges due to the so-called landlord-tenant dilemma. This issue arises because landlords have no direct financial benefits from energy efficiency retrofits if the tenant pays the energy bill. On the other hand, tenants have little motivation to save energy if the landlord covers this cost. The primary landlord-tenant dilemma results from rent control limiting rent levels in existing tenancies. The secondary dilemma is due to the undervaluation of energy cost savings in the new rental market. Tenancy law, through the allocation system for energy and retrofit costs, can either address or worsen these issues. This paper develops an analytical model to examine how efficiently various allocation systems incentivize retrofits and energy conservation and how they compare in terms of improving the welfare of both landlords and tenants. I analyze several systems: a free market model without and with rent control, the current German system, a slight variation of the German system, the Swedish inclusive rent system, a consumption-based partially inclusive rent system, and a novel demand-based partially inclusive rent system. The German status quo could theoretically offer optimal incentives if it were ideally set up; however, it interacts in a complex way with other aspects of German tenancy law, hindering optimal design. In contrast, the demand-based partially inclusive rent system is more likely to set efficient incentives consistently but would require substantial reforms in tenancy law.
The hyperintensionality of art
Authors: Vacek Daniela , Vacek Martin 
Published: January 2025

Abstract
Daniel Nolan successfully predicted a hyperintensional revolution in metaphysics in his 2014 paper ‘Hyperintensional Metaphysicsʼ. He argued that hyperintensionality is not restricted to representations. However, it seems that one of the most promising candidates for non-representational hyperintensionality has not yet been considered as such: art. We will argue that art can provide a rather strong case for non-representational hyperintensionality. One reason for this is that the hyperintensionality of art cannot be captured via a representational kind of hyperintensionality.
The bright and dark side of blue-enriched light on sleep and activity in older adults
Authors: Barroggi Constantino Débora , Lederle Katharina A. , Middleton Benita , Revell Victoria L. , Sletten Tracey L. , Williams Peter , Skene Debra J. , van der Veen Daan R. 
Published: January 2025

Abstract
Low indoor light in urban housing can disrupt health and wellbeing, especially in older adults who experience reduced light sensitivity and sleep/circadian disruptions with natural aging. While controlled studies suggest that enhancing indoor lighting may alleviate the negative effects of reduced light sensitivity, evidence for this to be effective in the real world is lacking. This study investigates the effects of two light conditions on actigraphic rest-activity rhythms and subjective sleep in healthy older adults (≥ 60 years) living at home. Two photon-matched lights were compared; a control white light (4000 K) and a blue-enriched white light (17000 K) at two different intensities (300–450 lx and 1100–1200 lx respectively). Participants (n = 36, 25 female) completed an 11-week randomized, cross-over study, comprising 1 week of baseline, 3 weeks of self-administered light exposure (2 h in the morning and 2 h in the evening), and 2 weeks of washout for each light condition. Participants completed sleep diaries, wore a wrist actigraph and a light sensor necklace, and collected urine to measure 6-sulphatoxymelatonin. Longer duration of morning blue-enriched light significantly improved rest-activity rhythm stability and decreased sleep fragmentation. More time spent above 2500 lx increased actigraphy amplitude, daytime activity, and advanced bedtime. Evening light exposure, however, increased sleep latency and lowered sleep efficiency. Our findings show morning blue-enriched light is beneficial whereas evening light should be avoided. Optimal timing of self-administered light interventions thus may offer a promising strategy to improve sleep and rest-activity rhythms in older adults in real-world settings.
Robotic hiatus hernia surgery: learning curve and lessons learned
Authors: Garsot Elisenda , Company-Se Georgina , Clavell Arantxa , Viciano Marta , Herrero Christian , Nescolarde Lexa 
Published: January 2025

Abstract
New procedures like the robotic approach require proficiency to ensure patient safety and satisfactory functional results. Hiatal hernia surgery serves as a suitable training procedure for upper gastrointestinal tract surgeons transitioning to the robotic approach. This study aims to evaluate the outcomes of implementing the robotic approach in hiatal hernia surgery at a tertiary hospital and to assess the associated learning curve. A retrospective review was conducted on 54 patients (58 surgeries) between June 2019 and March 2024, including both primary and revision robotic antireflux surgeries. The study focused on perioperative outcomes, symptom resolution, and the surgical learning curve, assessed using Cumulative Sum analysis. The results showed that global surgical time averaged 124 ± 57 (54–350) min, 127 ± 38 (116–139) for Primary Surgery and 164 ± 84 (115–212) min for Revisional Surgery. There were no conversions to laparoscopic or open approach. The global median of hospital stay was 2 days (2 for Primary Surgery and 3 for Revisional Surgery) and three patients required readmission (2 for Primary Surgery and 1 for Revisional Surgery). Postoperative complications occurred in 3 patients. Symptom resolution was achieved in 90% of Primary Surgery group and 85.7% of Revisional Surgery group. Learning curve described three phases: 1-training (case 1 to 14), 2-plateau (15 to 25) and 3-expertise phase (25 onwards). The robotic approach in hiatal hernia surgery is feasible with minimal morbidity, short hospital stays, and excellent functional results. With previous experience in laparoscopic approach and esophagogastric surgery the learning curve can be reduced to 14 procedures.
Grocery Shopping Under Simplified Marginal Value Theorem Predictions
Authors: Schlender Tabea , Rieger Alex , Eggert Frank 
Published: January 2025

Abstract
This study examined whether supermarkets can be considered patches in the marginal value theorem (MVT) sense despite their particular features and whether they are models of human food foraging in resource-dense conditions. On the basis of the MVT, the quantitative relationship between gains in the Euro and patch residence time was modeled as an exponential growth function toward an upper asymptote, allowing the choice of an optimal strategy under diminishing returns. N = 61 participants were interviewed about their current shopping trip and contextual variables at a German supermarket and provided data to estimate relevant model parameters. A nonlinear model of the patch residence time and resulting gain based on an exponential function was fitted via nonlinear orthogonal distance regression. The results generally revealed the relationships predicted by the model, with some uncertainty regarding the estimation of the upper asymptote due to a lack of data from participants with long residence times. Despite this limitation, the data support the applicability of the MVT-based model. The results show that approaches from optimal foraging theory, such as the MVT, can be used successfully to model human shopping behavior even when participants’ verbal reports are used.
Sensorless Position Estimation in Electromagnetic Launchers Using Recurrent Neural Networks with Repeated k-Fold Cross-Validation
Authors: Özbay Harun , Özer İlyas , Dalcali Adem , Çetin Onursal , Temurtaş Feyzullah 
Published: January 2025

Abstract
Systems utilizing electromagnetic launchers transform energy from one state to another. In electromagnetic launchers, the launched object follows the magnetic field generated by one or more fixed coils to achieve motion. Knowing the position of the projectile within the coil is crucial for efficient launching. In traditional systems, the position of the projectile is detected using different sensors. In this study, a sensorless method is proposed using Recurrent Neural Networks (RNNs) to estimate the projectile’s position based on current and voltage signals. Various RNNs architectures, including SimpleRNN, Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), and Bidirectional GRU (Bi-GRU), are evaluated through repeated k-fold cross-validation. The GRU model achieved the highest accuracy with 94.88%, demonstrating the feasibility of sensorless position estimation in electromagnetic launchers. However, limitations such as the sensitivity of the model to noise in electrical measurements and the need for extensive data for training must be addressed. Despite these challenges, the proposed method offers a cost-effective and simplified alternative to sensor-based systems, particularly in environments where sensor integration is impractical. This approach has the potential to enhance the reliability and performance of electromagnetic launch systems.
Chronic Urticaria in Africa, What We Know and What We Do Not: A Systematic Review
Authors: Day Cascia , Peter Jonny 
Published: January 2025

Abstract

Purpose of Review
Despite global incidence, considerable morbidity, and diverse triggers, CU is poorly characterized amongst diverse African populations. This systematic review aims to describe available African CU studies and unmet needs.

Recent Findings
Overall 221 publications were screened and 29 were eligible for full review. These publications represented only 12 of 54 African countries, with 38% from Nigeria. Most publications described CU within the context of dermatology out-patient clinics(21/29), with a CU prevalence of 0.03–10.4%. Two studies detailed CU demographics, with a female predominance and median age of 30–40 years. CU patients reported variable associations with infections, including T.canis(Egypt), and H.pylori(Nigeria and South Africa), with other risk factors including foods, food additives, and low vitamin D levels. UAS was reported for < 100 CU patients, and only two studies detailed and CU co-morbidities, while none addressed other patient-reported outcome or quality-of-life measures, treatment access and/or efficacy.

Summary
Despite considerable disease prevalence, CU is poorly detailed in African populations. Further CU studies are required to detail phenotypes, disease severity and describe treatment use and unmet needs.
Effect of artificial viscosity on shocked particle-laden flows for staggered grid Lagrangian methods
Authors: Barclay Paul L. , Harrison Alan K. 
Published: January 2025

Abstract
Shocked particle-laden flows are important to many natural and industrial processes. When simulating these systems, artificial viscosity is often required to prevent numerical artifacts, such as ringing, from arising in the pressure and density fields. The linear and quadratic coefficients of the artificial viscosity determine the amount of smoothing that occurs in these fields. For particle-laden flows, however, many of the fluid–particle interaction forces, for example, the pressure gradient force and unsteady forces, depend on gradients in the fluid fields. Furthermore, while the shock passes over a particle, these forces can be more dominant than drag. This means that the artificial viscosity coefficients affect how a particle and fluid interact when simulating shocked particle systems. Here this effect is investigated for isolated particles and for a particle curtain using a staggered grid Lagrangian approach. The artificial viscosity coefficients have a significant impact on the maximum force that a fluid imparts to a particle, which is important for determining whether a particle will break up in response to the shock. Furthermore, it is found that the density ratio between the particle and the fluid is important in determining whether the artificial viscosity coefficients have a significant impact on the particle’s motion.
Exponiertheit im Sportunterricht
Authors: Edelmann Tino , Müller Arno , Jurkowski Susanne 
Published: January 2025

Zusammenfassung
Im Sportunterricht sind Schüler:innen aufgrund der Öffentlichkeit unterrichtlicher Handlungen besonders exponiert. Die damit einhergehende mögliche soziale Bewertung durch Mitschüler:innen kann das emotionale Erleben des Sportunterrichts beeinflussen. Positive Sozialbeziehungen, die einen sicheren Rahmen für die Lernenden schaffen, erscheinen unverzichtbar. In der vorliegenden Studie wurde der Zusammenhang zwischen der Qualität der Sozialbeziehungen und dem emotionalen Erleben in exponierten Sportunterrichtsphasen untersucht. Es nahmen N = 82 Schüler:innen aus vier Klassen der Jahrgangsstufen fünf bis sieben an der Untersuchung teil (M = 11,65, SD = 0,91, 56,1 % weibl.). Über Selbsteinschätzungen der Schüler:innen wurden die Qualität der Lehrer:in-Schüler:innen-Beziehung und die Qualität der Peerbeziehungen erfasst. Exponiertheit wurde für insgesamt 36 einzelne Unterrichtsphasen aus zwölf Sportstunden anhand eines Kodiersystems auf der Grundlage von Beobachtungen beurteilt. Darüber hinaus berichteten die Schüler:innen für jede Unterrichtsphase über ihr emotionales Erleben (Zufriedenheit, Freude, Wut/Ärger). Mehrebenenanalysen zeigen, dass eine stärkere Exponiertheit mit weniger Zufriedenheit und Freude und mehr Wut/Ärger zusammenhängt. Günstige Sozialbeziehungen wirken sich hingegen positiv auf das emotionale Erleben aus. Eine positive Beziehung zur Lehrkraft moderiert zudem den Zusammenhang zwischen der Exponiertheit und dem emotionalen Erleben in dem Sinne, dass auch bei stärkerer Exponiertheit mehr Freude und weniger Wut/Ärger erlebt werden. Die Ergebnisse unterstreichen die Bedeutung von Beziehungsqualitäten im Sportunterricht und verweisen darauf, Überlegungen zur Exponiertheit in der Unterrichtsgestaltung zu berücksichtigen.
Effects of Intermittent Sprint-Based Heat Acclimation at Various Pedal Resistances on Physiological Responses During Incremental Exercise
Authors: McGregor Callum , Marley Andrew , Babraj John 
Published: January 2025

Abstract

Purpose
Standard heat acclimation (HA) protocols (low-moderate intensity over a continuous 7–14 days) restore performance and thermoregulation but lack specificity and practicality for intermittent sports athletes. This study compared different pedal resistances in a 3-week intermittent sprint-based HA protocol.

Methods
Fourteen physically active adults were assigned to a sprint pedal resistance training group (TG): 0.075 kg/kg (7.5TG, 6 males, 1 female) or 0.085 kg/kg (8.5TG, 5 males, 2 females). Participants completed baseline incremental time to exhaustion test (TTE), continued with own training for 3 weeks before post-control TTE, then carried out 6 × 15 s cycle sprints with 30 s recovery followed by 30 min low intensity cycling thrice weekly for 3 weeks before completing post-HA TTE test. Testing and HA were completed at 38 °C and 30% relative humidity.

Results
Both groups improved TTE from baseline to post-HA (7.5TG: 9.6% ± 10.8%, 8.5TG: 7.4% ± 3.1%) and post-control to post-HA (7.5TG: 11.0% ± 11.7%, 8.5TG: 6.7% ± 3.9%). Maximal power improved from baseline to post-HA (7.5TG: 293 ± 40 W vs. 321 ± 46 W, 8.5TG: 318 ± 90 W vs. 339 ± 96 W), while only 7.5TG improved maximal power from post-control to post-HA (289 ± 42 W vs. 321 ± 46 W). From baseline to post-HA and post-control to post-HA, only 7.5TG increased time till maximum skin temperature (460 ± 76 s vs. 509 ± 75 s, 461 ± 72 s vs. 509 ± 75 s, respectively) and minimum core-skin gradient (461 ± 71 s vs. 510 ± 74 s, 455 ± 75 s vs. 510 ± 74 s, respectively), while exercising core temperature remained unchanged in both groups. Both groups increased sweat rate (7.5TG: 7.0 ± 3.4 mg/cm2/min vs. 9.6 ± 4.1 mg/cm2/min, 8.5TG: 5.7 ± 3.6 mg/cm2/min vs. 8.3 ± 4.3 mg/cm2/min). Only 7.5TG delayed the onset of blood lactate accumulation from baseline to post-HA (259 ± 126 s vs. 354 ± 86 s).

Conclusion
Intermittent sprint-based HA improves TTE performance and sweat rate while a lighter sprint pedal resistance offers, greater thermal adaptation and fatigue tolerance.