bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a renal risk score for Japanese patients with ANCA-associated glomerulonephritis in a multi-center cohort study
Authors: Uchida Tomohisa , Ichinose Kunihiro , Yamashita Ayuko , Muta Kumiko , Kitamura Mineaki , Sato Shuntaro , Iwamoto Naoki , Nishino Tomoya , Kawakami Atsushi 
Published: March 2023

BackgroundIn patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, prediction of renal survival should guide the choice of therapy, but a prediction of the histological classification has inconsistencies.ObjectivesTo evaluate the usefulness of renal risk score (RRS) for Japanese patients with ANCA-associated glomerulonephritis (AAGN) and compare the prediction for end-stage renal disease (ESRD) between RRS and the histological classification.MethodsWe retrospectively analyzed 96 patients with AAGN who underwent a renal biopsy. Renal survival was categorized by RRS, and the histological classification was assessed separately. We compared the predictive values for RRS and the histological classification.ResultsThe median observational period was 37.5 (interquartile range [IQR] 21.5–77.0) months. The median RRS point at the time of renal biopsy was 2 (IQR 0–7.8), and the patients were categorized into low- (n = 29), medium- (n = 43), and high-risk groups (n = 24) using RRS. As expected, the renal prognosis was the worst in the “high-risk” group and the best in the “low-risk” group. In the histological classification, the survival deteriorated progressively from “focal” (best) to “mixed,” “crescentic,” and “sclerotic” (worst) classes, different from the order in the original proposal for this system. Multivariable Cox regression analysis revealed that RRS was independently associated with ESRD. The difference in prediction for renal survival between RRS and the histological classification was not significant using area under receiver-operating-characteristic curves.ConclusionWe evaluated the usefulness of RRS in Japanese patients with AAGN and found it a stable predictor of renal survival in such patients.
Metabolomic and cultivation insights into the tolerance of the spacecraft-associated Acinetobacter toward Kleenol 30, a cleanroom floor detergent
Authors: Mogul Rakesh , Miller Daniel R. , Ramos Brian , Lalla Sidharth J. 
Published: March 2023

IntroductionStringent cleaning procedures during spacecraft assembly are critical to maintaining the integrity of life-detection missions. To ensure cleanliness, NASA spacecraft are assembled in cleanroom facilities, where floors are routinely cleansed with Kleenol 30 (K30), an alkaline detergent.MethodsThrough metabolomic and cultivation approaches, we show that cultures of spacecraft-associated Acinetobacter tolerate up to 1% v/v K30 and are fully inhibited at ≥2%; in comparison, NASA cleanrooms are cleansed with ~0.8-1.6% K30.ResultsFor A. johnsonii 2P08AA (isolated from a cleanroom floor), cultivations with 0.1% v/v K30 yield (1) no changes in cell density at late-log phase, (2) modest decreases in growth rate (~17%), (3) negligible lag phase times, (4) limited changes in the intracellular metabolome, and (5) increases in extracellular sugar acids, monosaccharides, organic acids, and fatty acids. For A. radioresistens 50v1 (isolated from a spacecraft surface), cultivations yield (1) ~50% survivals, (2) no changes in growth rate, (3) ~70% decreases in the lag phase time, (4) differential changes in intracellular amino acids, compatible solutes, nucleotide-related metabolites, dicarboxylic acids, and saturated fatty acids, and (5) substantial yet differential impacts to extracellular sugar acids, monosaccharides, and organic acids.DiscussionThese combined results suggest that (1) K30 manifests strain-dependent impacts on the intracellular metabolomes, cultivation kinetics, and survivals, (2) K30 influences extracellular trace element acquisition in both strains, and (3) K30 is better tolerated by the floor-associated strain. Hence, this work lends support towards the hypothesis that repeated cleansing during spacecraft assembly serve as selective pressures that promote tolerances towards the cleaning conditions.
Predictors of cognitive impairment in newly diagnosed Parkinson’s disease with normal cognition at baseline: A 5-year cohort study
Authors: Chen Jing , Zhao Danhua , Wang Qi , Chen Junyi , Bai Chaobo , Li Yuan , Guo Xintong , Chen Baoyu , Zhang Lin , Yuan Junliang 
Published: March 2023

Background and objectiveCognitive impairment (CI) is a substantial contributor to the disability associated with Parkinson’s disease (PD). We aimed to assess the clinical features and explore the underlying biomarkers as predictors of CI in patients with newly diagnosed PD (NDPD; less than 2 years).MethodsWe evaluated the cognitive function status using the Montreal Cognitive Assessment (MoCA) and a battery of neuropsychological tests at baseline and subsequent annual follow-up for 5 years from the Parkinson’s Progression Markers Initiative (PPMI) database. We assessed the baseline clinical features, apolipoprotein (APO) E status, β-glucocerebrosidase (GBA) mutation status, cerebrospinal fluid findings, and dopamine transporter imaging results. Using a diagnosis of CI (combined mild cognitive impairment and dementia) developed during the 5-year follow-up as outcome measures, we assessed the predictive values of baseline clinical variables and biomarkers. We also constructed a predictive model for the diagnosis of CI using logistic regression analysis.ResultsA total of 409 patients with NDPD with 5-year follow-up were enrolled, 232 with normal cognitive function at baseline, and 94 patients developed CI during the 5-year follow-up. In multivariate analyses, age, current diagnosis of hypertension, baseline MoCA scores, Movement disorder society Unified PD Rating Scale part III (MDS-UPDRS III) scores, and APOE status were associated with the development of CI. Predictive accuracy of CI using age alone improved by the addition of clinical variables and biomarkers (current diagnosis of hypertension, baseline MoCA scores, and MDS-UPDRS III scores, APOE status; AUC 0.80 [95% CI 0.74–0.86] vs. 0.71 [0.64–0.77], p = 0.008). Cognitive domains that had higher frequencies of impairment were found in verbal memory (12.6 vs. 16.8%) and attention/processing speed (12.7 vs. 16.9%), however, no significant difference in the prevalence of CI at annual follow-up was found during the 5-year follow-up in NDPD patients.ConclusionIn NDPD, the development of CI during the 5-year follow-up can be predicted with good accuracy using a model combining age, current diagnosis of hypertension, baseline MoCA scores, MDS-UPDRS III scores, and APOE status. Our study underscores the need for the earlier identification of CI in NDPD patients in our clinical practice.
Adjuvant chemotherapy compared with observation in patients with T2aN0 stage IB lung adenocarcinoma
Authors: Lee Po-Hsin , Chiang Chun-Ju , Tseng Jeng-Sen , Zheng Zhe-Rong , Chen Kun-Chieh , Chu Cheng-Hsiang , Huang Yen-Hsiang , Hsu Kuo-Hsuan , Lee Wen-Chung , Yang Tsung-Ying , Liu Tsang-Wu , Hsia Jiun-Yi , Chang Gee-Chen 
Published: March 2023

IntroductionFor patients with T2aN0 stage IB lung adenocarcinoma, benefits of adjuvant chemotherapy remain controversial. Here, we aimed to evaluate such benefits.MethodsThis retrospective cohort study was conducted on the database of the National Taiwan Cancer Registry. We analyzed patients with T2aN0 stage IB lung adenocarcinoma (re-classified by AJCC 8th edition) diagnosed during the period from January 2011 to December 2017. They were divided into two groups: (1) group 1: tumor &lt;=3 cm with visceral pleural invasion (VPI); (2) group 2: tumor &gt;3 cm, but &lt;=4 cm. Overall survival (OS) and cancer specific survival (CSS) were evaluated. Risk factors for survival were determined.ResultsA total of 2,100 patients with T2aN0 stage IB lung adenocarcinoma (1,265 in group 1 and 835 in group 2) were enrolled for study. The proportions of patients receiving adjuvant chemotherapy in group 1 and 2 were 39.1% and 68.6%, respectively. Amongst group 1 patients, adjuvant chemotherapy was not an independent risk factor for OS and CSS. Amongst group 2 patients, high-grade histologic findings and receiving sublobar resection were two risk factors for poorer survival. Adjuvant chemotherapy was also associated with an OS (adjusted hazard ratio (aHR), 0.52; 95% confidence interval (CI), 0.38-0.72; P&lt;0.001) and CSS (aHR, 0.54; 95% CI, 0.37-0.78; p=0.001) benefit regardless of the presence or absence of risk factors.ConclusionFor patients with T2aN0 stage IB lung adenocarcinoma, adjuvant chemotherapy improved OS and CSS in those with tumors &gt;3 cm, but &lt;=4 cm.For patients with tumors &lt;=3 cm with VPI, adjuvant chemotherapy had no survival benefit.
Evaluation of aerial spraying application of multi-rotor unmanned aerial vehicle for Areca catechu protection
Authors: Wang Juan , Ma Chao , Chen Pengchao , Yao Weixiang , Yan Yingbin , Zeng Tiwei , Chen Shengde , Lan Yubin 
Published: March 2023

Multi-rotor unmanned aerial vehicle (UAV) is a new chemical application tool for tall stalk tropical crop Areca catechu, which could improve deposit performance, reduce operator healthy risk, and increase spraying efficiency. In this work, a spraying experiment was carried out in two A. catechu fields with two leaf area index (LAI) values, and different operational parameters were set. Spray deposit quality, spray drift, and ground loss were studied and evaluated. The results showed that the larger the LAI of A. catechu, the lesser the coverage of the chemical deposition. The maximum coverage could reach 4.28% and the minimum 0.33%. At a flight speed of 1.5 m/s, sprayed droplets had the best penetration and worst ground loss. The overall deposition effect was poor when the flight altitudes were greater than 11.09 m and the flight speed was over 2.5 m/s. Comparing flight speed of 2.5 to 1.5 m/s, the overall distance of 90% of the total drift increased to double under the same operating parameters. This study presents reference data for UAV chemical application in A. catechu protection.
Impact of inclusive leadership on employees’ innovative behavior: A relational silence approach
Authors: Wu Guo-feng , Li Mei 
Published: March 2023

IntroductionAlthough employees’ silence is a common phenomenon in organizations, the mediating role of relational silence has not been studied in inclusive leadership and innovative behavior. In this study, based on the theory of social exchange, relational silence is used as a mediating variable to explore the internal mechanisms of inclusive leadership on employees’ innovative behavior.MethodsData from 263 in-service leaders and employees were collected using convenience sampling and analyzed using Amos and SPSS statistical software package via questionnaires distributed to companies in six cities in the Guangdong province of China.ResultsThe results showed that inclusive leadership has a significant positive predictive effect on employees’ innovative behavior (β = 0.590, p &lt; 0.01), while inclusive leadership is negative and significantly correlated with relational silence (β = −0.469, p &lt; 0.01). More so, relational silence has a significant negative correlation with employees’ innovative behavior (β = −0.408, p &lt; 0.01), and relational silence partially mediates the relationship between inclusive leadership and employee innovation behavior.DiscussionThe mediating role of relational silence between inclusive leadership and employees’ innovative behavior is revealed for the first time, theoretically broadening and enriching the connotation of inclusive leadership’s influence mechanism on employees’ innovative behavior and providing new ideas in practice for constructing inclusive leadership styles, reducing the incidence of relational silence, and evoking employees’ innovative behavior.
Physical performance and muscle strength rather than muscle mass are predictor of all-cause mortality in hemodialysis patients
Authors: Chen Xiaoyu , Han Peipei , Zhang Kun , Liang Zhenwen , Yu Chen , Lu Ningtao , Shen Zhouyue , Chang Fengyan , Fang Xin , Guo Qi 
Published: March 2023

ObjectivesPatients undergoing maintenance hemodialysis usually suffer a high burden of poor functional status. The aim of this study was to investigate the association between muscle mass, muscle strength as well as physical performance with all-cause mortality in hemodialysis patients.Methods923 hemodialysis patients (565 men, mean aged 61.3 ± 12.7 years) were included from eight facilities in Tianjin and Shanghai of China from 2019 to 2021. Muscle mass was evaluated by skeletal muscle index (SMI) and muscle strength was assessed by handgrip strength. Different measures of physical performance were measured via gait speed, Timed Up and Go Test (TUGT) and short physical performance battery (SPPB). Cox proportional hazards regression models were used to determine the adjusted hazard ratios (HRs) of mortality with 95% confidence intervals (95% CIs) for baseline muscle mass, muscle strength and different measures of physical performance. Additionally, the area under the Receiver Operating Characteristic (ROC) curves were constructed to determine which index is a better predictor of mortality.ResultsDuring a median follow-up of 14 (12–17 months), 79 (8.6%) patients died. Using the Cox regression analysis, we founded that muscle strength and physical performance rather than muscle mass were significantly negatively associated with mortality. The C-index for different measures of physical performance in predicting mortality were 0.709 for SPPB, 0.7 for TUGT and 0.678 for gait speed, respectively. The C-index for muscle strength was 0.635, and the ability of prediction was significantly lower than the physical performance.ConclusionsPhysical performance seems to a better indicator of mortality than muscle mass and strength in hemodialysis patients. Simple measures of physical performance may be appropriately used as a screening tool targeting high-risk hemodialysis patients for the prevention of mortality.
The role of immunosuppression in long-term graft hepatitis and fibrosis after paediatric liver transplant – comparison of two treatment protocols
Authors: Haller Wolfram , Hodson James , Brown Rachel , Lloyd Carla , Hubscher Stefan , McKiernan Patrick , Kelly Deirdre 
Published: March 2023

Background and aimsWe have previously demonstrated high rates of chronic allograft hepatitis and fibrosis in liver transplant patients on long-term cyclosporine monotherapy. We subsequently changed practice to add low-dose prednisolone to maintenance treatment with tacrolimus post-transplant. The aim of the study was to assess the impact of the immunosuppression change on graft histopathology.MethodsPatients treated in this era (Tac + Pred, 2000–2009, N = 128) were compared to a historical cohort, who had been maintained on a steroid-free, cyclosporine-based regime (CSA-Only, 1985–1996, N = 129). Protocol liver biopsies and laboratory tests were performed five- and ten-years post-transplant in both groups.ResultsCompared to CSA-Only, the Tac + Pred cohort had significantly lower rates of chronic hepatitis (CH) at five (20% vs. 44%, p &lt; 0.001) and ten (15% vs. 67%, p &lt; 0.001) years post-transplant, with similar trends observed in inflammation and fibrosis at five years. The Tac + Pred cohort also had significantly lower hepatic transaminases and IgG levels and was less likely to be autoantibody positive at both time points. However, the degree of graft fibrosis at ten years did not differ significantly between eras (p = 0.356).ConclusionIncreased immunosuppression effectively reduced chronic allograft hepatitis and fibrosis at five years, suggesting it is an immunologically driven variant of rejection. However, there was no significant reduction in the degree of fibrosis at ten years, indicating a multifactorial origin for long term graft fibrosis.
Evaluation of the effect of a resorbable membrane on the closure of palatal fistulas
Authors: Wang Yufeng , Yang Fangling , Liu Weilong , Fan Xiaofen , Lu Yong 
Published: March 2023

PurposeA palatal fistula following the closure of palatal clefts remains a difficult clinical complication. Surgical treatment of fistulas is often complicated, with high recurrence rates. We present our results of fistula closure augmented with GTR, a resorbable membrane designed to promote guided tissue regeneration.MethodsWe reviewed the records of 75 patients operated on between 2008 and 2022 for closure of the palatal fistula. The patients included 24 who underwent fistula closure augmented with GTR and 51 who underwent fistula closure with other techniques. We reviewed the age at surgery, sex, fistula location, and outcome. Operation success was defined as an asymptomatic patient with a healed fistula on clinical examination.ResultsThe overall fistula closure rate was 79.1% in the GTR group and 76.5% in the non-GTR group(p = 0.79).DiscussionThe success rate of fistula closure in the GTR group is comparable to that in the non-GTR group in this study. An additional advantage is that this procedure does not require harvesting any autologous tissue and reduces tissue damage in the long term.
Age and sex ratios of wintering Long-tailed Ducks Clangula hyemalis can be determined by analysis of photos of flying flocks at sea: A method description
Authors: Larsson Kjell 
Published: March 2023

The West Siberian/North European population of Long-tailed Duck Clangula hyemalis that breeds in Fennoscandia and Northwestern Russia, and winters in the Baltic Sea, has declined by at least 65% since the 1990s and is classified as globally vulnerable. To propose effective management actions to stop the decline, knowledge about demographic parameters is required. A photo survey method by which it is possible, in winter, to collect data on sex ratios and production of first-winter birds is presented here. The plumage traits and bill patterns, which are detectable in photos taken at a distance, are described. The traits can be used to discriminate between three categories of birds: adult males, first-winter males, and females. To extrapolate results from several photo surveys and obtain population-wide estimates of demographic parameters, knowledge about non-random distributions of different bird categories is needed. It was found that different age and sex categories were distributed differently across flocks of different sizes. The required sample sizes and the possible constraints and biases related to the photo survey method are discussed.
Mapping Chinese Medical Entities to the Unified Medical Language System
Authors: Chen Luming , Qi Yifan , Wu Aiping , Deng Lizong , Jiang Taijiao 
Published: March 2023

Background
Chinese medical entities have not been organized comprehensively due to the lack of well-developed terminology systems, which poses a challenge to processing Chinese medical texts for fine-grained medical knowledge representation. To unify Chinese medical terminologies, mapping Chinese medical entities to their English counterparts in the Unified Medical Language System (UMLS) is an efficient solution. However, their mappings have not been investigated sufficiently in former research. In this study, we explore strategies for mapping Chinese medical entities to the UMLS and systematically evaluate the mapping performance.

Methods
First, Chinese medical entities are translated to English using multiple web-based translation engines. Then, 3 mapping strategies are investigated: (a) string-based, (b) semantic-based, and (c) string and semantic similarity combined. In addition, cross-lingual pretrained language models are applied to map Chinese medical entities to UMLS concepts without translation. All of these strategies are evaluated on the ICD10-CN, Chinese Human Phenotype Ontology (CHPO), and RealWorld datasets.

Results
The linear combination method based on the SapBERT and term frequency-inverse document frequency bag-of-words models perform the best on all evaluation datasets, with 91.85%, 82.44%, and 78.43% of the top 5 accuracies on the ICD10-CN, CHPO, and RealWorld datasets, respectively.

Conclusions
In our study, we explore strategies for mapping Chinese medical entities to the UMLS and identify a satisfactory linear combination method. Our investigation will facilitate Chinese medical entity normalization and inspire research that focuses on Chinese medical ontology development.
The Relationship Between Preschool Teachers’ Perceptions of Parental Approach and Levels of Emotional Labor
Authors: ŞEHİTOĞLU Münevver , KOÇYİĞİT Mehmet 
Published: March 2023

In this study, preschool teachers’ perceptions of parental approach, their
emotional labor levels, and the relationship between them were examined
regarding various variables. 220 preschool teachers working in public and private
preschool institutions in the 2020-2021 academic year participated in this
research. The Emotional Labor Scale and Parental Approach Scale were applied to
preschool teachers. It was found that there is a positive, moderate significant
relationship between the parental approach perceptions of preschool teachers
and their emotional labor levels. Preschool teachers scored highest from the
factor of "natural emotions" related to emotional labor, and the lowest in the
dimension of "superficial role playing". According to the answers given by the
preschool teachers regarding their perceptions of parental approach, the highest
mean was in the dimension of "positive and informative approach", and the lowest
was in the dimension of "negative and critical approach".
QUINZE ANOS DE EXISTÊNCIA
Authors: Ramos Rosangela Patriota , Ramos Alcides Freire , Costa Rodrigo de Freitas 
Published: March 2023

É com imensa satisfação que lançamos mais um número da Fênix – Revista de História e Estudos Culturais (Volume 17, Ano XVII, Número 1 – Janeiro / Junho – 2020). No momento em que a Fênix – Revista de História e Estudos Culturais completa QUINZE (15) anos de existência, temos de, mais uma vez, reiterar nossos sinceros agradecimentos e gratidão a todos(as) que se envolveram, com desprendimento e coragem, na efetividade desta revista.
Korelasi Kecepatan Dan Kelincahan Terhadap Keterampilan Dribbling Futsal
Authors: Mudian Deni , Prasetiyo Arif Fajar 
Published: March 2023

Penelitian ini bertujuan untuk mengetahui korelasi antara kecepatan dengan keterampilan dribbling pada permainan futsal, penelitian ini menggunakan metode deskriptif dengan studi korelasional. Populasi yang digunakan adalah klub ekstrakurikluer futsal dan sampel yang ambil sebanyak 30 orang atlet. Instrumen yang digunakan dalam penelitian ini yaitu pengukuran kecepatan menggunakan tes lari 40 meter), pengukuran kelincahan menggunakan illinois agiliti run, dan tes dribbling. Berdasarkan hasil pengolahan data yang dilakukan secara manual dan dengan bantuan software SPSS 20, dapat ditarik kesimpulan bahwa terdapat hubungan yang signifikan sebesar 0.858 dan memiliki interpretasi nilai koefisien korelasi bahwa kecepatan memiliki hubungan positif yang sangat kuat terhadap ketrampilan dribbling futsal dan memiliki kontribusi sebesar 70%. Terdapat hubungan yang signifikan sebesar 0.953 dan memiliki interpretasi nilai koefisien korelasi bahwa kelincahan memiliki hubungan positif yang sangat kuat terhadap ketrampilan dribbling futsal dan memiliki kontribusi 85,4%. Terdapat hubungan yang signifikan sebesar 0.965 dan memiliki interpretasi nilai koefisien korelasi bahwa kecepatan dan kelincahan memiliki korelasi positif terhadap ketrampilan dribbling futsal dan memiliki kontribusi sebesar 88,5%. Kesimpulannya adalah terdapat korelasi yang signifikan antara kecepatan, kelincahan dengan keterampilan dribbling pada permainan futsal