bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning Ion Transport at the Anode‐Electrolyte Interface via a Sulfonate‐Rich Ion‐Exchange Layer for Durable Zinc‐Iodine Batteries
Authors: Zhang Leiqian , Huang Jiajia , Guo Hele , Ge Lingfeng , Tian Zhihong , Zhang Mingjie , Wang Jingtao , He Guanjie , Liu Tianxi , Hofkens Johan , Brett Dan J.L. , Lai Feili 
Published: February 2023

AbstractRechargeable aqueous zinc‐iodine batteries (ZIBs) are considered a promising newly‐developing energy‐storage system, but the corrosion and dendritic growth occurring on the anode seriously hinder their future application. Here, the corrosion mechanism of polyiodide is revealed in detail, showing that it can spontaneously react with zinc and cause rapid battery failure. To address this issue, a sulfonate‐rich ion‐exchange layer (SC‐PSS) is purposely constructed to modulate the transport and reaction chemistry of polyiodide and Zn2+at the zinc/electrolyte interface. The resulting ZIBs can work properly over 6000 cycles with high‐capacity retention (90.2%) and reversibility (99.89%). Theoretical calculations and experimental characterization reveal that the SC‐PPS layer blocks polyiodide permeation through electrostatic repulsion, while facilitating desolvation of Zn(H2O)62+and restricting undesirable 2D diffusion of Zn2+by chemisorption.
Japanese national survey on declined liver allografts from brain‐dead donors: High decline rate but promising outcomes in allografts with moderate steatosis
Authors: Takemura Yusuke , Shinoda Masahiro , Hasegawa Yasushi , Yamada Yohei , Obara Hideaki , Kitago Minoru , Kasahara Mureo , Umeshita Koji , Eguchi Susumu , Kitagawa Yuko , Ohdan Hideki , Egawa Hiroto 
Published: February 2023

AbstractAimLiver allografts from brain‐dead donors, which were declined and were eventually not transplanted due to accompanying marginal factors, have never been surveyed in Japan. We surveyed the declined allografts and discussed the graft potential focusing on various marginal factors.MethodsWe collected data on brain‐dead donors between 1999 and 2019 from the Japan Organ Transplant Network. We divided their liver allografts into declined (nontransplanted) and transplanted ones, and then characterized declined ones focusing on their timepoints of decline and accompanying marginal factors. For each marginal factor, we calculated the decline rate from the number of declined and transplanted allografts, and assessed the 1‐year graft survival rate from transplanted allografts.ResultsA total of 571 liver allografts were divided into 84 (14.7%) declined and 487 (85.3%) transplanted ones. In the declined allografts, a majority was declined after laparotomy (n = 55, 65.5%), most of which had steatosis and/or fibrosis (n = 52). Out of the moderate steatotic (without F ≥ 2 fibrosis) allografts (n = 33), 21 were declined and 12 were transplanted, leading to a 63.6% decline rate. The latter 12 achieved a 92.9% 1‐year graft survival rate after transplantation. Comparison of donor background showed no significant difference between the declined and transplanted allografts.ConclusionPathological abnormalities of steatosis/fibrosis seem to be the most common donor factor leading to graft decline in Japan. Allografts with moderate steatosis were highly declined; however, transplanted ones achieved promising outcomes. This national survey highlights the potential utility of liver allografts with moderate steatosis.
Habitat and ecological niche characteristics of the elusive Hairy‐eared Dwarf Lemur (Allocebus trichotis) with updated occurrence and geographic range data
Authors: Schüßler Dominik , Rabemananjara Naina R. , Radriarimanga Tahiriniaina , Rafamantanantsoa Stephan M. , Randimbiharinirina Roger D. , Radespiel Ute , Hending Daniel 
Published: February 2023

AbstractEcological niche modeling (ENM) is particularly useful in the study of cryptic and elusive species that are only rarely seen, difficult to study in the wild, and simultaneously threatened by a multitude of anthropogenic factors. We collected presence records one such example, the understudied Hairy‐eared Dwarf Lemur (Allocebus trichotis), from the literature and supplemented these with observations from surveys in previously unstudied areas to model its fundamental and realized niche throughout Madagascar. We further evaluated habitat characteristics at each sighting location to judge its conservation status and its adaptability toward habitat degradation. We found 31 presence localities in the literature and directly observed A. trichotis a further 23 times. According to the ENMs, precipitation of the driest quarter and maximum temperature of the warmest month mostly influenced its distribution, restricting it to the higher altitudes of the northeastern humid forests of Madagascar. Its fundamental niche, extent of occurrence, and area of occupancy were estimated as 65,819, 53,054, and 16,967 km² respectively. The latter, however, declined by 29.2% since 1990. On a habitat level, it was most often observed in primary forest habitats of different degradation stages (85.7%, n = 21). The fundamental niche of A. trichotis is most likely restricted by climatic factors. Although it can be found in moderately degraded forests, it is known to depend on the availability of tree holes and therefore old‐growth forest structures. Ongoing deforestation and habitat fragmentation are likely to be the major threats to the survival of this species. Our ENMs provide evidence on where to intensify survey efforts on the elusive Hairy‐eared Dwarf Lemurs of Madagascar.
Dried blood spot characterization of sex‐based metabolic responses to acute running exercise
Authors: Cendali Francesca , D'Alessandro Angelo , Nemkov Travis 
Published: February 2023

AbstractMetabolomics and lipidomics techniques are capable of comprehensively measuring hundreds to thousands of small molecules in single analytical runs and have been used to characterize responses to exercise traditionally using venipuncture‐produced liquid samples. Advanced microsampling devices offer an alternative by circumventing the requirement to maintain frozen samples. This approach combines a microneedle puncture for blood draw with microfluidic sample collection onto a dried carrier and has thus far been employed for targeted measurements of a few analytes. To demonstrate the utility of advanced dried microsampling to characterize metabolomic and lipidomic changes during exercise, we obtained samples before and after a 2‐mile run from twelve (8 male, 4 female) healthy volunteers with various ranges in activity levels. Results highlighted significant changes in whole blood levels of several metabolites associated with energy (glycolysis and Tricarboxylic Acid cycle) and redox (Pentose Phosphate Pathway) metabolism. Lipid changes during this same period were individualized and less uniform. Sex‐based differences in response to running highlighted reliance on carbohydrate or fat substrate utilization in males or females, respectively. The results presented herein illustrate the ability of this approach to monitor circulating metabolome and lipidome profiles from field sampled blood in response to exercise.
Modified Dirac Fermions in the Crystalline Xenon and Graphene Moiré Heterostructure
Authors: Im Suji , Im Hayoon , Kim Kyoo , Lee Ji‐Eun , Hwang Jinwoong , Mo Sung‐Kwan , Hwang Choongyu 
Published: February 2023

AbstractThe interface between two‐dimensional (2D) crystals often forms a Moiré superstructure that imposes a new periodicity, which is a key element in realizing complex electronic phases as evidenced in twisted bilayer graphene. Acombined angle‐resolved photoemission spectroscopy measurements and first‐principles calculations reveal the formation of a Moiré superstructure between a 2D Dirac semi‐metallic crystal, graphene, and a 2D insulating crystal of noble gas, xenon. Incommensurate diffraction pattern and folded Dirac cones around the Brillouin zone center imply the formation of hexagonal crystalline array of xenon atoms. The velocity of Dirac fermions increases upon the formation of the 2D xenon crystal on top of graphene due to the enhanced dielectric screening by the xenon over‐layer. These findings not only provide a novel method to produce a Moiré superstructure from the adsorption of noble gas on 2D materials, but also to control the physical properties of graphene by the formation of a graphene‐noble gas interface.
Towards an integrated decision‐making support framework for the sustainable production and use of biomass
Authors: Ebadian Mahmood , Gonzales‐Calienes Giovanna , Shadbahr Jalil , Vazifehkoorabbasloo Zahra , Bensebaa Farid 
Published: February 2023

AbstractThe decision‐making landscape to maximize the use of sustainable biomass resources, and achieve long‐term environmental and socioeconomic benefits, is complex with a high level of uncertainty in biomass supply and logistics, technical and economic performance of the biorefinery routes, lifecycle performance of the finished products, and other sustainability criteria. Numerous decision‐making support models have been developed but these models usually assess only a few specific aspects of technology, regulations, economic, environment, and society. Decision‐making support models with a limited capability to capture environmental and socioeconomic performance of the biorefining pathways are not able to identify the best available biorefining routes. This study reviews and discusses recent progress on the harmonization, standardization, and integration of the existing decision‐making support models that aim to improve the comparability of the results of these models when different pathways are being assessed and align the decisions made at the strategic, tactical and operational levels. With the growing number of climate‐change policies and greenhouse gas (GHG) emission reduction targets, national and international efforts to harmonize the input databases, the model assumptions and system boundaries, and the integration of the existing models have been increasing. However, the deployment of the integrated frameworks among the bioeconomy stakeholders that are capable of evaluating and identifying the promising biorefining routes with significant economic, social and environmental benefits is still not a common practice. This study proposes an integrated decision‐making support framework to identify cost‐competitive, low‐carbon fuel production pathways that are technically viable and can potentially provide maximum GHG emission reduction.
Evo‐devo beyond development: Generalizing evo‐devo to all levels of the phenotypic evolution
Authors: Salazar‐Ciudad Isaac , Cano‐Fernández Hugo 
Published: February 2023

AbstractA foundational idea of evo‐devo is that morphological variation is not isotropic, that is, it does not occur in all directions. Instead, some directions of morphological variation are more likely than others from DNA‐level variation and these largely depend on development. We argue that this evo‐devo perspective should apply not only to morphology but to evolution at all phenotypic levels. At other phenotypic levels there is no development, but there are processes that can be seen, in analogy to development, as constructing the phenotype (e.g., protein folding, learning for behavior, etc.). We argue that to explain the direction of evolution two types of arguments need to be combined: generative arguments about which phenotypic variation arises in each generation and selective arguments about which of it passes to the next generation. We explain how a full consideration of the two types of arguments improves the explanatory power of evolutionary theory. Also see the video abstract here: https://youtu.be/Egbvma_uaKc
Pheochromocytoma disguised as gestational hypertensive disease during pregnancy: A case report
Authors: Kumari Swati , Lamichhane Ramesh , Giri Subarna , Chaudhary Saroj , Neupane Shanta , Dangol Neha 
Published: February 2023

AbstractPheochromocytoma is often diagnosed prior to pregnancy. Sometimes, the disease may be diagnosed for the first‐time during pregnancy masking itself as a hypertensive disease in pregnancy. Early diagnosis and timely, appropriate management reduce possible maternal and fetal complications. We identified a case of pheochromocytoma during pregnancy misdiagnosed as preeclampsia.
A patient with leishmaniasis presenting with longstanding pancytopenia and hepatosplenomegaly
Authors: Onsongo Simon , Mulwa Evelyne , Mutiso Bonface 
Published: February 2023

AbstractLeishmaniasis is a common cause of pancytopenia and hepatosplenomegaly in tropical and subtropical regions. A high index of suspicion is required to diagnose and manage patients with leishmaniasis. Travel history should always be elicited in a patient with suggestive clinical presentation.
A tale about an unusual cause of pygalgia in non‐radiographic axial spondyloarthritis
Authors: Dhahri Rim , Bettaieb Hiba , Slouma Maroua , Khrifech Yasmine , Mallat Youssef , Amri Khalil , Harbaoui Ahmed , Metoui Leila , Gharsallah Imen , Louzir Bassem 
Published: February 2023

AbstractSchwannoma are tumors of Schwann cells of the peripheral nerve sheath. Sacral location is rarely reported especially in spondyloarthritis patients. Herein, we report a case of uncommon pygalgia in a 25‐year‐old man with history of a non‐radiographic axial spondyloarthritis and in whom the diagnosis of sacral Schwannoma was established.
Process Simulation of Twin‐Screw Granulator: Effect of Screw Configuration on Size Distribution
Authors: Arthur Tony B. , Sekyi Nana K. G. , Rahmanian Nejat , Pu Jaan 
Published: February 2023

AbstractThe effect of screw configuration on granule size distribution (GSD) using gPROMS FormulatedProduct (gFP) software to perform optimization, estimation of complex processes, and analyses is evaluated. Twin‐screw granulation modeling was used to investigate the contribution of screw configuration and liquid‐to‐solid (L/S) ratio on GSD. Lactose and Avicel were the granulating materials. Twelve different configurations were investigated under three feed rates as consistent with literature and at various L/S ratios. Results indicate that kneading elements promote the recovery of 100–1000 µm granules while reducing the production of oversized granules. Higher feed rates support the production of fines and agglomerates, while a low feed rate produces 100–1000 µm granules.
Efficient resolution of 4‐chlormandelic acid enantiomers using lipase@UiO‐67(Zr) zirconium–organic frameworks in organic solvent
Authors: Zhong Long‐Jin , Jiang Bihui , Tang Kewen 
Published: February 2023

AbstractA new biocatalyst PCL@UiO‐67(Zr) was successfully synthesized by immobilized lipases on metal–organic frameworks (MOFs) materials. Compare with free lipases, zirconium foundation organic framework material UiO‐67(Zr) modification on immobilized lipases Pseudomonas cepacia lipase (PCL) great boosts their enantioselectivity in the kinetic resolution racemic 4‐chloro‐mandelic acid (4‐ClMA) on the organic solvent. The acquired bio‐composite PCL@UiO‐67(Zr) was fully characterized by powder X‐ray diffraction (PXRD), Fourier transform infrared (FT‐IR) spectroscopy, N2 adsorption–desorption isotherm and aperture distribution map, and scanning electron microscopy (SEM). The catalytic performance of PCL@UiO‐67(Zr), such as temperature, reaction time, and lipase quantity, were deeply explored. The experiment results showed resolution racemic 4‐ClMA optimum conditions that 20 mmol/L of (R, S)‐4‐chloromandelic acid, 120 mmol/L vinyl acetate, 30‐mg immobilized lipases PCL@UiO‐67(Zr), 2 mL of MTBE, 500 rpm, and under the 55°C reaction 18 h. In this optimum conditions, c and eep could reach up to 47.6% and 98.7%, respectively.
Allergy screening with extract‐based skin prick tests demonstrates higher sensitivity over in vitro molecular allergy testing
Authors: Gureczny Tobias , Heindl Benjamin , Klug Livia , Wantke Felix , Hemmer Wolfgang , Wöhrl Stefan 
Published: February 2023

AbstractBackgroundAs extract‐based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how many patients would be underdiagnosed, if only one test could be used.MethodsIn a retrospective analysis, we investigated a cohort of 2646 patients seen by a single physician in a large Austrian outpatient allergy clinic in 2018. Only patients with an allergen source‐specific history and pairs of extract‐based skin prick (SPT) and in vitro molecular allergy tests to major allergens were included.ResultsFor all tested allergen sources, sensitivity was higher for SPT than for sIgE‐based molecular allergy testing. Concerning 1006 birch pollen‐allergic patients, 791 (78.6%) had positive results with both tests, while 153 (15.2%) only with the SPT and 62 (6.2%) only with the sIgE to Bet v1. The other allergen sources showed similar results: For house dust mite 816/1120 (72.9%), grass pollen 1077/1416 (76.1%) and cat 433/622 (69.6%) remained test‐positive with both procedures, whereas in 276 (24.6%), 224 (15.8%) and 173 (27.8%) times only the SPT and 28 (2.5%), 115 (8.1%) and 16 (2.6%) times only the sIgE to Der p1/2/23, Phl p1/5 and Fel d1 showed a positive result. Each comparison was statistically significant (each p < 0.0001, Chi‐squared test).ConclusionsScreening for allergy with major molecular allergens has lower sensitivity when compared with extract‐based skin tests. A combination of both is required for an optimal sensitivity.
Janus liquid marbles: Fabrication techniques, recent developments, and applications
Authors: Lekshmi Bindhu Sunilkumar , Varanakkottu Subramanyan Namboodiri 
Published: February 2023

AbstractLiquid marbles (LMs) are nonsticky droplets stabilized by hydrophobic solid particles that are adsorbed at the liquid–air interface. LMs are emerging as a potential platform in digital microfluidics, sensing applications, storage unit, biological incubation, and cosmetic applications. Incorporating multifunctional particles to form Janus liquid marble (JLM) could enhance the capabilities of the pristine LM. JLMs are multifunctional next‐generation LMs comprising two hemispherical domains of distinct physicochemical properties such as size, hydrophobicity, electrical conductivity, surface functionalization, stimuli‐responsivity, and so on. The JLMs offer precise control on the manipulability and enhanced performance over pristine LMs. Though the properties, applications, and progress of LMs are detailed in the recent literature, a focused review encompassing the fabrication, recent developments, potential applications of JLMs, and the challenges regarding its reliable fabrication remains a gap in the literature. The review provides insights into the importance of JLMs, systematically discussing the fabrication strategies, applications, challenges, and future directions.
Improvement in output power of vibration generators based on piezoelectric elements by using internal capacitor cancel control rectifier
Authors: Minami Masataka , Nakagaki Akito , Hase Genki 
Published: February 2023

AbstractRecently, energy harvesting has attracted increasing attention. The present study focuses on vibration generators based on piezoelectric elements by proposing an internal capacitor cancel control (ICCC) rectifier to improve the output power. The proposed rectifier cancels the internal capacitor to improve the output power while retaining the maximum output power. Accordingly, this paper experimentally demonstrates the improvement in output power by using the ICCC rectifier compared to conventional circuits and the previous proposed circuit.
DNA methylation‐based age prediction with bloodstains using pyrosequencing and random forest regression
Authors: Yang Fenglong , Qian Jialin , Qu Hongzhu , Ji Zhimin , Li Junli , Hu Wenjing , Cheng Feng , Fang Xiangdong , Yan Jiangwei 
Published: February 2023

AbstractThe use of DNA methylation to predict chronological age has shown promising potential for obtaining additional information in forensic investigations. To date, several studies have reported age prediction models based on DNA methylation in body fluids with high DNA content. However, it is often difficult to apply these existing methods in practice due to the low amount of DNA present in stains of body fluids that are part of a trace material. In this study, we present a sensitive and rapid test for age prediction with bloodstains based on pyrosequencing and random forest regression. This assay requires only 0.1 ng of genomic DNA and the entire procedure can be completed within 10 h, making it practical for forensic investigations that require a short turnaround time. We examined the methylation levels of 46 CpG sites from six genes using bloodstain samples from 128 males and 113 females aged 10–79 years. A random forest regression model was then used to construct an age prediction model for males and females separately. The final age prediction models were developed with seven CpG sites (three for males and four for females) based on the performance of the random forest regression. The mean absolute deviation was less than 3 years for each model. Our results demonstrate that DNA methylation‐based age prediction using pyrosequencing and random forest regression has potential applications in forensics to accurately predict the biological age of a bloodstain donor.
An optimized live bacterial delivery vehicle safely and efficaciously delivers bacterially transcribed therapeutic nucleic acids
Authors: Mora Darcy S. O. , Cox Madeline , Magunda Forgivemore , Williams Ashley B. , Linke Lyndsey 
Published: February 2023

AbstractThere is an unmet need for delivery platforms that realize the full potential of next‐generation nucleic acid therapeutics. The in vivo usefulness of current delivery systems is limited by numerous weaknesses, including poor targeting specificity, inefficient access to target cell cytoplasm, immune activation, off‐target effects, small therapeutic windows, limited genetic encoding and cargo capacity, and manufacturing challenges. Here we characterize the safety and efficacy of a delivery platform comprising engineered live, tissue‐targeting, non‐pathogenic bacteria (Escherichia coli SVC1) for intracellular cargo delivery. SVC1 bacteria are engineered to specifically bind to epithelial cells via a surface‐expressed targeting ligand, to allow escape of their cargo from the phagosome, and to have minimal immunogenicity. We describe SVC1's ability to deliver short hairpin RNA (shRNA), localized SVC1 administration to various tissues, and its minimal immunogenicity. To validate the therapeutic potential of SVC1, we used it to deliver influenza‐targeting antiviral shRNAs to respiratory tissues in vivo. These data are the first to establish the safety and efficacy of this bacteria‐based delivery platform for use in multiple tissue types and as an antiviral in the mammalian respiratory tract. We expect that this optimized delivery platform will enable a variety of advanced therapeutic approaches.