bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolerability of endometriosis medical treatment: a comparison between combined hormonal contraceptives and progestins
Authors: Pinheiro Denise Joffily Pereira da Costa , Pereira Ana Maria Gomes , Antonini Marcelo , Salgado Isabella Maria Albuquerque , Dias Alexandre Torchio , Lopes Reginaldo Guedes Coelho 
Published: March 2023

Abstract
Endometriosis is a chronic inflammatory disease that occurs in women of reproductive age. Much of the treatment involves hormone therapy that suppresses the proliferation of endometriosis lesions.

Objective

to compare discontinuation rates of pharmacological treatment with estrogen-progestins and progestins medications. The secondary objective is to evaluate the main side effects of these drugs in patients with endometriosis.

Methods

this retrospective study analyzed data from 330 patients who attended the Hospital of the State Public Servant of São Paulo from August 1999 to September 2020 and received pharmacological treatment for endometriosis. The data were obtained by review of the files of medical appointments with specialized staff.

Results

the median treatment time was 18 months, ranging from 1 to 168 months, and 177 patients interrupted the proposed treatment. The combined contraceptives with estrogens and progestins were significantly linked to treatment interruption, with a relative risk of 1,99 (p = 0,005). The most important side effects that resulted in treatment interruption were pain persistence (p = 0,043), weight gain (p = 0,017) and spotting (p < 0,001).
Seroprevalence of SARS-CoV-2 Among Healthcare Workers in Two Governorates Hospitals, Yemen
Authors: Taher Watheq Thabet , Bawazir* Amen , Salam Talal , Alsurimi Khaled 
Published: March 2023

Abstract
Background
Healthcare workers (HCWs) are at a higher risk of contracting COVID-19 due to their close contact with infected patients. However, the true burden of COVID-19 among HCWs in Yemen is unknown due to the inadequacy of the healthcare system and the subclinical nature of the disease. This study aims to estimate the seroprevalence of SARS-CoV-2 infection among HCWs in two Yemeni governorates and identify associated factors using a cross-sectional design.
Method
A total of 404 HCWs were surveyed from June 2022 to September 2022 in Lahj and AL-Dhalea hospitals. A self-administered questionnaire collected demographic data, COVID-19 infection history, and vaccination status. Sera were tested using a specific electrochemiluminescence immunoassay assay. Association analysis was conducted to identify associations between antibody prevalence and demographic and vaccine-related variables.
Result
The mean age of the HCWs was 33 ± 9.0 years, with 65.0% being male and 35.0% female. Of all HCWs surveyed, 94% were SARS-CoV-2 seropositive, and 72.0% had no confirmed test of COVID-19-related symptoms. There was no significant association between seropositivity and age, gender, occupation, or COVID-19 vaccination (P > 0.05).
Conclusion
The seroprevalence of SARS-CoV-2 was high among HCWs in Yemen, primarily due to natural infection rather than vaccination. Compliance with infection prevention and control measures did not significantly affect seropositivity. This study highlights the need for improved healthcare systems and resources to reduce the burden of COVID-19 among HCWs in Yemen.
Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized AdV-hACE2 NIKO mouse model
Authors: Yong Kylie Su Mei , Anderson Danielle E , Zheng Adrian Kang Eng , Liu Min , Tan Sue Yee , Tan Wilson Wei Sheng , Chen Qingfeng , Wang Lin-Fa 
Published: March 2023

Abstract
The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized AdV-hACE2 NOD-SCID IL2Rγ-/- (NIKO) mouse model and compared infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized AdV-hACE2 NIKO mice. Humanized AdV-hACE2 NIKO mice infected with the WT and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
Friction-induced planar vibration of a two-rigid-disc system with a finite contact area subjected to uncertain friction
Authors: Hu Han , Batou Anas , Ouyang Huajiang , Liu Ningyu 
Published: March 2023

Abstract
Friction-induced vibration of mechanical systems has significant academic appeal and industrial implications. This paper presents a novel approach to studying the friction-induced planar vibrations of a two-rigid-disc system with a finite contact area. In this approach, a set of discrete two-dimensional LuGre models are introduced to calculate the dynamics of the system, eliminating the need for a stick-slip transition criterion required by static friction models. Complex eigenvalue analysis and transient dynamic analysis are performed to analyse the linear stability and bifurca- tion properties of the system. The spatial variation of the coefficient of friction is also considered, modelled for the first time as an interval field, and is found to greatly impact the system’s stick-slip behaviour and cause oscillations around equilibrium points.
Nationwide incidence of congenital and infantile cataract requiring surgery in Korea
Authors: Kim Dong Geun , Lee Da Yun , Woo Se Joon , Park Kyu Hyung , Park Sang Jun 
Published: March 2023

Abstract
Congenital and infantile (CI) cataract is one of the most important and preventable cause of blindness in children but the incidence has not been studied in Korea. We collected data from the national claims database of the National Health Insurance Service of Korea from 2002 through 2019. We identified children who underwent cataract surgery within the age of 5 years, and cumulative incidence rates were calculated for each of the three age criteria. 989 patients out of 4,221,459 births underwent surgery with CI cataract during the period. The cumulative incidence rates per 10,000 births were 1.60 (0–1 years), 2.38 (0–3 years), and 2.95 (0–5 years), respectively. The incidence peaked in the 2007 birth cohort, which coincides with the start of the national screening program for infants/children. Primary intraocular lens implantation was performed in 439 patients (44%). Strabismus and glaucoma were diagnosed in 825 (83%) and 692 (70%) within 8 years of cataract surgery. The incidence rates of CI cataract in Korea appear to be comparable to previous studies in other regions. The early screening program for infants may reduce delayed diagnosis and increase the proportion of patients undergoing surgery at a critical time for visual development.
HIV-Related Knowledge &amp; Health Care Seeking Barriers among Transgender Individuals in Dhaka City: A cross-sectional Study
Authors: Rahman Md. Mantaka , Alam Ummul Khair 
Published: March 2023

Abstract
Background: The prevalence of HIV among Transgender is 1% while only 0.9% in Dhaka City having one-third times a lifetime higher risk of HIV infection. Being minority group barriers faced by transgenders for healthcare-seeking are major public health concerns.
Methods: This was a cross-sectional study purposively selecting 135 transgender from Drop-in-center and three Hijra pollis of Dhaka City. Data was collected using a semi-structured questionnaire containing a Likert scale regarding HIV-related knowledge.
Results: Majority were professional sex sellers including 54.1% having irregular sexual clients. 48.9% had been engaged in sex work for more than 10 years. Although more than half (57%) had good HIV-related knowledge. Only one-third (37.3%) sometimes used barrier method and more than half (58%) had knowledge of HIV symptoms. The barriers were negligence (16%), inconvenient location(12.43%), long waiting time(8.1%), and not knowing where to get the service (5.8%). Transgenders from DIC had higher HIV-related knowledge than hijra pollis [t (95% CI)=.168, p=.000] Those having HIV-related higher knowledge didn’t feel the necessity of isolated health corners [t (95% CI)= -3.799, p= .001]
Conclusion: Although DIC provides healthcare services but existing facilities barriers need to be addressed to extend health services.
Tamoxifen reduces mitochondrial respiration, oncogenic signaling and mutant allele burden in a myeloproliferative neoplasm subset
Authors: Fang Zijian , Fattori Giuditta , McKerrell Thomas , Boucher Rebecca , Jackson Aimee , Fletcher Rachel , Forte Dorian , Martin Jose-Ezequiel , Fox Sonia , Roberts James , Glover Rachel , Harris Erica , Bridges Hannah , Grassi Luigi , Rodriguez-Meira Alba , Mead Adam , Knapper Steven , Ewing Joanne , Butt Nauman , Jain Manish , Francis Sebastian , Clark Fiona , Coppell Jason , McMullin Mary , Wadelin Frances , Narayanan Srinivasan , Milojkovic Dragana , Drummond Mark , Sekhar Mallika , ElDaly Hesham , Hirst Judy , Paramor Maike , Baxter Elizabeth , Godfrey Anna , Harrison Claire , Mendez-Ferrer Simon 
Published: March 2023

Abstract
Current therapies for myeloproliferative neoplasms (MPN) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem and progenitor cells (HSPCs). TAMARIN is a Phase-II, multicenter, single-arm clinical trial assessing tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2V617F, CALRins5 or CALRdel52 peripheral blood allele burden ≥20%. The primary outcome (≥50% allele burden reduction at 24 weeks) was met by 3/38 patients; 5/38 additional patients showed ≥25% reductions. Tamoxifen was well tolerated. Baseline analysis of HSPC transcriptome segregated responders and non-responders, suggesting a predictive signature. In responder HSPCs, longitudinal analysis showed high baseline expression of JAK-STAT signaling and oxidative phosphorylation genes, which were downregulated by tamoxifen. In JAK2V617F+ cells, 4-hydroxytamoxifen inhibited mitochondrial complex-I, activating proapoptotic integrated stress response (ISR) and decreasing pathogenic JAK2 signaling. Therefore, tamoxifen inhibits mitochondrial respiration, modulates ISR and suppresses pathogenic JAK-STAT signaling in a subset of prospectively identifiable MPN patients.
Modelling antimicrobial resistance transmission to guide personalized antimicrobial stewardship interventions and infection control policies in healthcare setting: a pilot study
Authors: Durazzi Francesco , Pezzani Maria Diletta , Arieti Fabiana , Simonetti Omar , Canziani Lorenzo Maria , Carrara Elena , Barbato Lorenzo , Onorati Francesco , Remondini Daniel , Tacconelli Evelina 
Published: March 2023

Abstract
Infection control programs and antimicrobial stewardship have been proven effective in reducing the burden of diseases due to multidrug-resistant organisms, but quantifying the effect of each intervention is an open issue. For this aim, we propose a model to characterize the effect of interventions at single ward level. We adapted the Ross-Macdonald model to describe hospital cross-transmission dynamics of carbapenemase-resistant Klebsiella pneumoniae, considering healthcare workers as the vectors transmitting susceptible and resistant pathogens among admitted patients. The model parameters were estimated from a literature review, further adjusted to reproduce observed clinical outcomes, and validated using real life data from a 2-year study in a university hospital. The model has been further explored through extensive sensitivity analysis, in order to assess the relevance of single interventions as well as their synergistic effects. Our model has been shown to be an effective tool to describe and predict the impact of interventions in reducing K. pneumoniae colonisations and infections, and can be extended to other specific hospital and pathological scenarios to produce tailored estimates of the most effective strategies.
Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year- old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?
Authors: Azzarà Cecilia , Lombardi Andrea , Gramegna Andrea , Ori Margherita , Gori Andrea , Blasi Francesco , Bandera Alessandra 
Published: March 2023

Abstract
Background: Immune checkpoint inhibitors (ICIs) are drugs growingly employed in cancer immunotherapy which have significantly improved the prognosis of several tumours. ICIs act by restoring the "exhausted" immune system against a specific pathogen and this have been linked to an increased risk of infectious events.
Case presentation: We present the case of a 67-year-old man with locally advanced lung adenocarcinoma treated with the anti-PD-L1 durvalumab. Three months after immunotherapy started, a radiologic progression was found with elements suggesting a parenchymal superinfection associated with weight loss, asthenia, and sputum emission. A bronchoalveolar lavage resulted positive for Mycobacterium chimaera, and treatment with amikacin iv (for eight weeks) and daily azithromycin, ethambutol, and rifampicin was started. Ten months after treatment started, the patient is alive with a stable lung condition.
Conclusions: The case highlights the risk of non-tuberculous mycobacteria lung disease (NTM-LD) in patients receiving ICIs treatment. Our hypothesis is that durvalumab induced an exaggerated immune response toward mycobacteria, leading to immunopathology and overt clinical manifestations. Clinicians should be aware of this possibility in patients receiving ICIs developing new signs/symptoms related to the respiratory tract, especially in countries with a high prevalence of NTM-LD.
Application of data mining based on swarm intelligence algorithm in financial support of livestock and poultry breeding insurance
Authors: Wang Yuanyuan 
Published: March 2023

Abstract
Among the components of China's actual economic structure, aquaculture has always been a key project, and as a part of agriculture, it has been greatly developed. However, there are still many problems in the actual breeding process, such as low financial support, low information transparency, high financing difficulty and lack of channels, high claims costs and serious moral hazard in the livestock and poultry breeding insurance field, which will affect the development and progress of the industry, Therefore, in this context, this paper improves the efficiency analysis of financial support for livestock and poultry breeding insurance by introducing data mining and swarm intelligence algorithms. Then use the analysis data to build a model to further evaluate the efficiency of financial support. The construction of the model is roughly divided into four parts: insurance density, insurance depth, insurance amount and income. The weight of different indicators is calculated through the analytic hierarchy process, and the overall ranking results are output through consistency test. Some data of the above models are used as the output indicators of DEA decision-making units for top-down ranking. The result analysis shows that the development of technology in this industry can effectively improve the actual productivity of agricultural crops, thus effectively promoting the development of local agriculture. In this paper, data mining and swarm intelligence algorithms are introduced into livestock and poultry breeding insurance to complete the analysis and evaluation of financial support.
Modeling policy pathways to maximize renewable energy growth and investment in Democratic Republic of the Congo using OSeMOSYS
Authors: Dalder Jacob 
Published: March 2023

Abstract
Keeping global warming from evolving into irreversible climate disaster requires immediate and sustained decarbonization of global energy systems. Of urgent priority are the energy systems in low- and middle-income countries (LMICs) where billions of people are projected to gain energy access in the next several decades. Therefore, leapfrogging traditional fossil fuel-based electricity production in favor renewable energy technologies is a critical issue area for sustainability. In the Democratic Republic of the Congo, political and economic challenges mean $44B in external investment is required to achieve its 2030 emissions reduction targets. Additionally, RETs are often more expensive.
This study sought to generate, evaluate, and recommend possible national policies for the DRC government to implement to most effectively boost growth and investment in RETs. Financial incentives were identified as the policy type most practical for DRC. Modeling the resulting energy systems for policy pathways involving a 16% RET subsidy, a 70% fossil fuel tax, and both in combination relative to no-policy baseline scenarios, the scenarios including the tax had the lowest net costs and the highest proportion of RETs (above 90%). Additionally, despite current reliance on hydropower to fulfill 98% of its energy needs, hydropower plays a very minor role in all modeled scenarios. Finally, a post-modeling market potential assessment was performed on the technology that dominated off-grid supply across policy pathways: the 0.3 kW small solar home system (SHS). Based on learning rates for solar PV, demand for the small SHS system in DRC (>160 million units in total) was found to be sufficient to substantially reduce the unit cost as deployment scales.
Putting results into context, emissions reductions for the policy pathways were higher than a past study focused on distributed RETs in DRC, and system costs were 15% higher than estimated in other analysis. These results provide a novel contribution to the literature by demonstrating how financial incentive policies can influence RET uptake in DRC specifically. Ultimately, this study yielded four policy recommendations for the DRC government:
1. Pursue financial incentives to catalyze DRC’s renewable energy supply
2. Tax fossil fuel energy production
3. Re-evaluate focus on hydropower
4. Promote DRC as a healthy market for solar home systems
Effect of Knee Isometric Flexion on Hamstring and Vertical Spine Muscle Stiffness
Authors: Chen Mengtong , Zhang Yuting , Li Yuanchao , He Yanan , Liang Hongying , Yu Suiqing , Huang Chen , Zhang Zheng , Liu Chunlong 
Published: March 2023

Abstract
MyotonPRO was used to measure the stiffness of hamstring and erector spinae muscles to investigate the degree of activation of different regions of hamstring and erector spinae muscles by isometric knee flexion at different angles, and to analyze the continuity of myofascial mechanical chains between the tissues of low back and lower extremity by the characteristics of changes in the stiffness of hamstring and erector spinae muscles to provide reference for the practical application of rehabilitation training. 20 healthy adult females were recruited, and the stiffness of semitendinosus (ST), biceps femoris muscle(BF), dominant and non-dominant side erector spinae muscles were measured by MyotonPRO at different angles (90°, 60°, 30°) of prone knee isometric flexion. We found that the stiffness of the ST and nondominant erector spinae muscles gradually increased as the knee flexion angle decreased, with the highest muscle stiffness at 30°. BF and dominant erector spinae muscles showed a tendency to increase and then decrease, with the highest muscle stiffness at 60°; there was a moderate to strong correlation between the BF and nondominant erector spinae muscles (r=0.451,p<0.05; r=0.716, p< 0.0001)The data suggest that 30°-60° is the optimal angle range for training the hamstrings and that there is a moderate to strong correlation between stiffness changes in the lower extremity muscles and the erector spinae, providing data to support the analysis of the continuity of the myofascial mechanical chain between the low back and lower extremity tissues.
Careless response effect in the moderation analysis of the self-efficacy construct: A brief report
Authors: Merino-Soto César , Cruz Gustavo Calderón-de la , Manzanares-Medina Eduardo , Correa-Rojas Jossué , García-Rivas Javier , Toledano-Toledano Filiberto 
Published: March 2023

Abstract
There are many studies on the relationship between academic self-efficacy and academic performance; however, there has not been a moderation analysis performed on the impact of carelessness/insufficient effort (C/IE) on the relationship between academic self-efficacy and perceived academic performance. A total of 731 adolescents school children (Lima, Peru) from a public educational institution participated. Two moderators were used, namely the sex and age of participants, and a sensitivity analysis was performed using both clean and dirty C/IE data. The prevalence of C/IE was 14.3% of the possible cases. The interaction between self-efficacy and age was affected, while the main effect of self-efficacy remained strong. It is concluded that the effect of moderators changes only slightly when their effect size is not weak.
Simulation of Video image detection in leisure sports tourism industry based on convolutional neural network
Authors: Tao Tingxue , Long Juan 
Published: March 2023

Abstract
Due to the continuous development of information technology, emerging technologies such as 5G networks, Turing devices and deep learning are widely used in people's lives. At present, the sports and tourism industry has become a pillar industry supporting the national economy. Sports events have attracted many people's attention, and people are willing to devote themselves to sports activities. Participants and visitors are also increasing day by day. The article also conducts research on the rapid detection of human video behavior, obtains more representative features for this demand. This research is of great help to the development of the industry. This allows the network to manipulate the input video behavior at different scales and extract deeper video information. Therefore, this paper proposes another 3D convolutional neural network model that combines a multi-level pyramid network with an attention mechanism. The visual attributes in the video behavior data set are explicitly learned to refine the classification of similar features. This paper also proposes an integrated neural network based on visual attribute enhancement. It also shows good adaptability, and can complete video data processing based on time series. The extraction of time and space functions is realized by the two-stream neural network method,the two networks learn the corresponding pixel ratios, and it is not easy to lose the clues of the action recognition. This paper also proposes a spatio-temporal convolutional neural network video for human body recognition algorithm, which is applied to the leisure tourism industry according to the specific analysis of the above method, and promotes the development of the industry.