bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonepisodic angioedema with eosinophilia after COVID-19 vaccination: a case successfully treated with reslizumab
Authors: Nam Young-Hee 
Published: February 2023

Abstract
Background
Angioedema with eosinophilia (AE) is a rare allergic disease classified as episodic or nonepisodic. AE is characterized by angioedema, urticaria, fever, weight gain, and eosinophilia, but its etiology and pathogenesis have not yet been clarified.

Case presentations
We present a 70-year-old woman presented with generalized edema and urticaria after Moderna COVID-19 vaccination. Peripheral blood eosinophil count was marked elevated and echocardiography and Doppler ultrasonography of both the upper and lower extremities were unremarkable. Her symptoms and peripheral blood eosinophil count were improved after systemic steroid therapy, but she failed to respond to steroid tapering. Reslizumab (anti-interluekin-5) was administered intravenously, and she remained symptom free with a normal eosinophil count during 8 months of reslizumab treatment without steroids.

Conclusions
We report a case of nonepisodic AE after COVID-19 vaccination that was successfully treated with reslizumab.
Modulation of foraging-like behaviors by cholesterol-FGF19 axis
Authors: Huang Alyssa , Maier Matthew T. , Vagena Eirini , Xu Allison W. 
Published: February 2023

Abstract
Background
Foraging for food precedes food consumption and is an important component of the overall metabolic programming that regulates feeding. Foraging is governed by central nervous system neuronal circuits but how it is influenced by diet and hormonal signals is still not well understood.

Results
In this study, we show that dietary cholesterol exerted suppressive effects on locomotor activity and that these effects were partially mediated by the neuropeptide Agouti-related protein (AgRP). High dietary cholesterol stimulated intestinal expression of fibroblast growth factor 15 (Fgf15), an ortholog of the human fibroblast growth factor 19 (FGF19). Intracerebroventricular infusion of FGF19 peptide reduced exploratory activity in the open field test paradigm. On the other hand, the lack of dietary cholesterol enhanced exploratory activity in the open field test, but this effect was abolished by central administration of FGF19.

Conclusions
Experiments in this study show that dietary cholesterol suppresses locomotor activity and foraging-like behaviors, and this regulation is in part mediated by AgRP neurons. Dietary cholesterol or the central action of FGF19 suppresses exploratory behaviors, and the anxiogenic effects of dietary cholesterol may be mediated by the effect of FGF19 in the mouse brain. This study suggests that dietary cholesterol and intestinal hormone FGF15/19 signal a satiating state to the brain, thereby suppressing foraging-like behaviors.
Evaluation, management and future perspectives of anal pruritus: a narrative review
Authors: Jakubauskas Matas , Dulskas Audrius 
Published: February 2023

Abstract
Purpose
The without a time limitation. Most recent search was performed on 1st June 2022.

Results
Thorough history and physical examination are very important in view of multiple possible causes of anal pruritus. Most of the focus during examination is drawn on to the perianal region. A digital rectal examination and an anoscopy are essential. It is necessary aim of this narrative review is to overview the classification, diagnostics, possible treatment options and future perspective of anal pruritus.

Methods
The search was performed by two authors (AD and MJ) independently in the following electronic databases: PubMed, EMBASE, Web of Science, Cochrane Library, CENTRAL and the Allied and Complementary Medicine Databases (AMED). Search was restricted to English language only to avoid moisture and the use of soaps in the perianal region. Furthermore, the patient should avoid certain foods and increase the intake of fiber. If the symptoms do not resolve, topical steroids, capsaicin (0.006%) and tacrolimus (0.1%) ointments may be used. For intractable cases, intradermal methylene blue injection might give a long-lasting symptom relief.

Conclusion
Anal pruritus is a long-term deteriorating quality of life issue. Most of the time it is a symptom with a difficult diagnosis. Thorough history and examination should be performed for the best possible treatment.
Validity of household survey indicators to monitor food security in time and space: Burkina Faso case study
Authors: Deléglise Hugo , Bazié Yves Gérard , Bégué Agnès , Interdonato Roberto , Roche Mathieu , Teisseire Maguelonne , Maître d’Hôtel Elodie 
Published: February 2023

Abstract
Background
The timely and accurate identification of food insecurity situations represents a challenging issue. Household surveys are routinely used in low-income countries and are an essential tool for obtaining key food security indicators that are used by decision makers to determine the targets of food security interventions.

Methodology
This paper investigates the spatial and temporal quality of the food security indicators obtained through household surveys. The empirical case of Burkina Faso is used in this paper, where a large-scale rural household survey has been conducted yearly since 2009. From this data set, three food security indicators (the Food Consumption Score, the Household Dietary Diversity Score and the Coping Strategies Index) are calculated at the regional level for each year during the 2009–2017 period.

Results
Results highlight that observed spatiotemporal variations in these indicators are consistent with the major regional food shocks reported in food warning system reports and are significantly correlated with variations computed from other sources of data, such as satellite images, rainfall and food prices.

Conclusion
These results raise new research questions on food security monitoring systems and on the use of heterogeneous data and multiple food security indicators.
Tsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex
Authors: Kashii Hirofumi , Kasai Shinya , Sato Atsushi , Hagino Yoko , Nishito Yasumasa , Kobayashi Toshiyuki , Hino Okio , Mizuguchi Masashi , Ikeda Kazutaka 
Published: February 2023

Abstract
Background
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline mutations of either the TSC1 or TSC2 gene, but somatic mutations were identified in both genes, and the combined effects of TSC1 and TSC2 mutations have been unknown.

Methods
The present study investigated social behaviors by the social interaction test and three-chambered sociability tests, effects of rapamycin treatment, and gene expression profiles with a gene expression microarray in Tsc1 and Tsc2 double heterozygous mutant (TscD+/−) mice.

Results
TscD+/− mice exhibited impairments in social behaviors, and the severity of impairments was similar to Tsc2+/− mice rather than Tsc1+/− mice. Impairments in social behaviors were rescued by rapamycin treatment in all mutant mice. Gene expression profiles in the brain were greatly altered in TscD+/− mice more than in Tsc1+/− and Tsc2+/− mice. The gene expression changes compared with wild type (WT) mice were similar between TscD+/− and Tsc2+/− mice, and the overlapping genes whose expression was altered in mutant mice compared with WT mice were enriched in the neoplasm- and inflammation-related canonical pathways. The “signal transducer and activator of transcription 3, interferon regulatory factor 1, interferon regulatory factor 4, interleukin-2R α chain, and interferon-γ” signaling pathway, which is initiated from signal transducer and activator of transcription 4 and PDZ and LIM domain protein 2, was associated with impairments in social behaviors in all mutant mice.

Limitations
It is unclear whether the signaling pathway also plays a critical role in autism spectrum disorders not caused by Tsc1 and Tsc2 mutations.

Conclusions
These findings suggest that TSC1 and TSC2 double mutations cause autistic behaviors similarly to TSC2 mutations, although significant changes in gene expression were attributable to the double mutations. These findings contribute to the knowledge of genotype–phenotype correlations in TSC and suggest that mutations in both the TSC1 and TSC2 genes act in concert to cause neurological symptoms, including autism spectrum disorder.
Do executive functions predict physical activity behavior? A meta-analysis
Authors: Gürdere Ceren , Strobach Tilo , Pastore Massimiliano , Pfeffer Ines 
Published: February 2023

Abstract
Background
Executive functions (EFs) are important determinants of health behaviors. In the present study, a meta-analysis was conducted to investigate the relationship between EFs and physical activity (PA) behavior.

Methods
Systematic searches were carried out in PsycInfo, MEDLINE, and SPORTDiscus databases throughout April 2021. Prospective empirical studies conducted with general healthy populations across the lifespan, which reported the relationship between baseline EFs and later PA behavior were selected.

Results
Eight studies were found eligible. Results of the multilevel meta-analysis revealed a small but significant total effect size for EFs on PA behavior of z = 0.12. High heterogeneity was observed among studies. When potential moderators were tested, residual heterogeneity remained significant and the effects of the moderators were not significant. The effect size dropped when accounted for publication bias.

Conclusions
Despite limitations, the study provided evidence for EFs’ determinant role on PA behavior. More research is however encouraged to inform PA promotion programs that are well-prepared for individual differences in EFs.
Processing speed predicts SuperAging years later
Authors: Ticha Zuzana , Georgi Hana , Schmand Ben , Heissler Radek , Kopecek Miloslav 
Published: February 2023

Abstract
Background
SuperAging is one of the current concepts related to elite, resilient or high-functioning cognitive aging. The main aim of our study was to find possible predictors of SuperAgers (SA).

Methods
Community-dwelling older persons (N = 96) aged 80–101 years in 2018 were repeatedly tested (year 2012 and 2018). SA were defined based on their performance in 2018 as persons of 80+ years of age who recalled ≥ 9 words in the delayed recall of the Philadelphia Verbal Learning Test, and had a normal performance in non-memory tasks [the Boston Naming Test, the Trail Making Test Part B, and Category Fluency (“Animals”)], which was defined as a score within or above one standard deviation from the age and education appropriate average. Three composite scores (CS; immediate memory, processing speed, and executive functions) were created from the performance in 2012, and analysed as possible predictors of SA status in 2018.

Results
We identified 19 SA (15 females) and 77 nonSA (42 females), groups did not significantly differ in age, years of education, and sex. The logistic regression model (p = 0.028) revealed three predictors of SA from the baseline (year 2012), including processing speed (p = 0.006; CS-speed: the Prague Stroop Test—Dots and the Digit Symbol Substitution Test), sex (p = 0.015), and age (p = 0.045).

Conclusions
Thus, SA may be predicted based on the level of processing speed, which supports the hypothesis of the processing speed theory of healthy aging.
E-diagnostic assessment of collaborative and individual oral tiered task performance in differentiated second language instruction framework
Authors: Rafi Fahimeh , Pourdana Natasha 
Published: February 2023

AbstractDifferentiated second/foreign language (L2) instruction (DI) has received growing attention in pedagogical research. Yet, as a cornerstone of inclusive education, the DI is still under-documented. In this study, we integrated diagnostic assessment (DIA) and collaborative language learning in a differentiated (tiered) oral tasks intervention and mediated them in a Google Meet cyber classroom. To do so, an intact group of 64 non-English major university students was selected, pretested, and randomly assigned to collaborative (CG) and individual (IG) groups. Each group was partitioned into higher, middle, and lower language ability tiers. The objectives were to examine (1) how differently mixed-ability English-as-a-foreign-language (EFL) learners could improve their collaborative and individual oral tiered task performances on which they received e-DIA for 10 weeks, and (2) how differently e-DIA could affect their postintervention learning achievement in oral skills. The statistical analysis indicated the positive and equal impact of e-DIA on CG-tiers, but a positive and divisive impact on IG-tiers. Responded to e-DIA, both groups had significant pretest-to-postest learning achievement in oral skills, but CG-tiers’ collaboration resonated with the impact of e-DIA to outperform the IG-tiers on the posttest. The findings implied the integration of e-DIA and collaborative learning in the DI framework to mitigate L2 learners’ diversity in inclusive L2 education.
Does more mean better? Remote-sensing data for monitoring sustainable redevelopment of a historical granary in Mydlniki, Kraków
Authors: Gawronek Pelagia , Noszczyk Tomasz 
Published: February 2023

Abstract
The Post-2015 UN Development Agenda includes culture and links the preservation of cultural heritage (CH) to sustainable development. In principle, sustainable redevelopment of CH should preserve historical qualities and ensure the financial profitability of the asset. Still, being a construction process, it has to be under constant change monitoring. Bearing in mind the quality of data achieved by measurement systems, TLS instruments can be used to capture 3D spatial data for cultural heritage. The authors analyse the usefulness of TLS data as the spatial database for the redevelopment and functional reuse of a historical granary. Following measurements on various stages of the redevelopment of the CH asset, TLS data undergo principally simple and rapid analyses (shape analysis, determination of the pace and scope of redevelopment, detection of conservation effort results, HBIM) to improve decision-making capabilities within the project. Contrary to the universal approach, periodic CH redevelopment scanning involves the entire structure, not merely its most valuable heritage components. As a result, not only doesthe remote-sensing data acquisition for monitoring of sustainable redevelopment of cultural heritage record the state of the revitalised building, but it also demonstrates the potential of periodic measurements as the primary source of insight into the heritage asset and the directions and quality of changes it undergoes.
Hollow Ni/NiO/C composite derived from metal-organic frameworks as a high-efficiency electrocatalyst for the hydrogen evolution reaction
Authors: Do Ha Huu , Tekalgne Mahider Asmare , Le Quyet Van , Cho Jin Hyuk , Ahn Sang Hyun , Kim Soo Young 
Published: February 2023

AbstractMetal-organic frameworks (MOFs) constitute a class of crystalline porous materials employed in storage and energy conversion applications. MOFs possess characteristics that render them ideal in the preparation of electrocatalysts, and exhibit excellent performance for the hydrogen evolution reaction (HER). Herein, H–Ni/NiO/C catalysts were synthesized from a Ni-based MOF hollow structure via a two-step process involving carbonization and oxidation. Interestingly, the performance of the H–Ni/NiO/C catalyst was superior to those of H–Ni/C, H–NiO/C, and NH–Ni/NiO/C catalysts for the HER. Notably, H–Ni/NiO/C exhibited the best electrocatalytic activity for the HER, with a low overpotential of 87 mV for 10 mA cm−2 and a Tafel slope of 91.7 mV dec−1. The high performance is ascribed to the synergistic effect of the metal/metal oxide and hollow architecture, which is favorable for breaking the H–OH bond, forming hydrogen atoms, and enabling charge transport. These results indicate that the employed approach is promising for fabricating cost-effective catalysts for hydrogen production in alkaline media.
Comparison of tropospheric delay correction methods for InSAR analysis using a mesoscale meteorological model: a case study from Japan
Authors: Sailellah Sardila Nurulhikmah , Fukushima Yo 
Published: February 2023

AbstractA major source of error in interferometric synthetic aperture radar (InSAR), used for mapping ground deformation, is the delay caused by changes in the propagation velocity of radar microwaves in the troposphere. Correcting this tropospheric delay noise using numerical weather models is common because of their global availability. Various correction methods and tools exist; selecting the most appropriate one by considering weather models, delay models, and delay calculation algorithms is essential for specific applications. We compared the performance of two tropospheric delay correction methods applied to Advanced Land Observing Satellite-2 (ALOS-2) data acquired over Japan, where the atmospheric field is complex with significant seasonal variation. We tested: (1) a method of delay integration along the slant radar line-of-sight (LOS) path using the mesoscale model (MSM) provided by the Japan Meteorological Agency and (2) the Generic Atmospheric Correction Online Service (GACOS) for InSAR, which estimates delay using the high-resolution forecast (HRES)-European Centre for Medium-Range Weather Forecasts (ECMWF) products along with an iterative decomposition approach. The results showed that the tropospheric delay correction using the slant-delay integration approach with MSM, which has a finer temporal and spatial resolution, performed slightly better than GACOS. We further found that the differences in the refractivity models would have limited significance, suggesting that the difference in performance mainly originates from differences in the numerical weather models being used. This study highlights the importance of using the best-available numerical weather model data for tropospheric delay calculations.
Graphical Abstract
Anti-vibriosis bioactive molecules from Arctic Penicillium sp. Z2230
Authors: Guo Jiacheng , Yang Jin , Wang Pei , Guo Bo , Li Huifang , Zhang Di , An Faliang , Gao Song 
Published: February 2023

AbstractVibrio species (Vibrio sp.) is a class of Gram-negative aquatic bacteria that causes vibriosis in aquaculture, which have resulted in big economic losses. Utilization of antibiotics against vibriosis has brought concerns on antibiotic resistance, and it is essential to explore potential antibiotic alternatives. In this study, seven compounds (compounds 1–7) were isolated from the Arctic endophytic fungus Penicillium sp. Z2230, among which compounds 3, 4, and 5 showed anti-Vibrio activity. The structures of the seven compounds were comprehensively elucidated, and the antibacterial mechanism of compounds 3, 4, and 5 was explored by molecular docking. The results suggested that the anti-Vibrio activity could come from inhibition of the bacterial peptide deformylase (PDF). This study discovered three Penicillium-derived compounds to be potential lead molecules for developing novel anti-Vibrio agents, and identified PDF as a promising antibacterial target. It also expanded the bioactive diversity of polar endophytic fungi by showing an example in which the secondary metabolites of a polar microbe were a good source of natural medicine.
Graphical Abstract
Ensemble rainfall–runoff and inundation simulations using 100 and 1000 member rainfalls by 4D LETKF on the Kumagawa River flooding 2020
Authors: Kobayashi Kenichiro , Duc Le , Kawabata Takuya , Tamura Atsushi , Oizumi Tsutao , Saito Kazuo , Nohara Daisuke , Sumi Tetsuya 
Published: February 2023

AbstractThis paper presents the 1000 ensemble flood simulations using ensemble rainfalls simulated by 4D LETKF. The number of ensemble rainfall members is large as 1000 compared to the operational rainfall products of two-digit numbers to avoid sampling errors in the three-dimensional meteorological simulation based on chaotic theory. Using the large data set, 1000 ensemble rainfall–runoff for dam catchments and high-resolution inundation simulations of large area are carried out focusing on the Kumagawa river catchment. Herewith, the comparisons were carried out with 21-member ensemble rainfalls of an operational forecast by Japan Meteorological Agency and 100-member 4D-LETKF ensemble rainfalls simulated independent of 1000-member 4D-LETKF. At the same time, the accuracy of selective 100-member ensembles out of 1000 members is investigated. As a result, although many previous research works show a large number of ensemble simulations are necessary for three-dimensional meteorological field, the number could be reduced in the catchment-average rainfall–runoff and 2.5-dimensional inundation simulations given that the rainfall prediction has a certain level of accuracy since improving the discharge prediction accuracy with lower dimension is sometimes possible by adjusting the horizontally/vertically integrated model parameters determined by topography and soil characteristics in advance against the observed rainfall. Also, the 1000 ensembles could be classified into several patterns in horizontally accumulated 2D rainfall field. Likewise, the flood flow moves toward the low elevation area and river; thus, the resultant 2.5-dimensional flood field does not show much variety as three-dimensional meteorological simulation. The paper summarizes these studies.