bluuebunny/crossref_metadata_2025_split huggingface dataset:
The crystal structure of ethyl 4-hydroxy-2-(4-methoxyphenyl)-5-oxo-1-(2-oxo-2H-chromen-6-yl)-2,5-dihydro-1H-pyrrole-3-carboxylate, C23H19NO7
Authors: Chakraborty Bimal Bhushan , Paul Saurav , Anwar Siddique , Choudhury Sudip 
Published: September 2023

Abstract
C23H19NO7, monoclinic, P21/n (no. 14), a = 17.9964(9) Å, b = 5.9211 Å, c = 18.8608(10) Å, β = 98.201(3)°, V = 1989.23(18) Å3, Z = 4, R

gt
(F) = 0.0496, wR

ref
(F
2) = 0.1561, T = 296 K.
Design and optimization of a TiO2/RGO-supported epoxy multilayer microwave absorber by the modified local best particle swarm optimization algorithm
Authors: Karami Mohammad Reza , Jaleh Babak , Eslamipanah Mahtab , Nasri Atefeh , Rhee Kyong Yop 
Published: September 2023

Abstract
Microwave absorbers have many applications in medical, industrial, and military devices. Polymeric composites including carbon-based filler can be used as lightweight absorbers with high electromagnetic (EM) wave absorption performance. Hence, multilayer microwave absorbers were designed using titanium dioxide (TiO2)/reduced graphene oxide (RGO)/epoxy nanocomposites with different weight percentages manufactured using refluxing and annealing methods. The characterization of nanocomposite indicated thin layers of TiO2/RGO as divided sheets in epoxy. The EM properties of the nanocomposites were examined using the Nicolson-Ross-Weir (NRW) detection method. The S-parameters were measured using PNA-N5222A Microwave Network Analyzer. The multilayer absorber software was designed based on the modified local best particle swarm optimization algorithm by MATLAB software, in which the material and thickness of layers were optimized with two cost functions in X-band frequencies. The first cost function seeks to reach the best absorption bandwidth, and the second cost function seeks to reach the maximum average return loss (RL) of the frequency range of 8.2–12.4 GHz. A maximum bandwidth with an RL of less than −12.81 dB was obtained with a thickness of 2.4 mm. A maximum average RL of −22.1 dB was obtained with a thickness of 2.6 mm. The maximum absorption peak was observed with a thickness of 2.5 mm with −62.82 dB at a frequency of 10.86 GHz.
Post-ovulatory aging affects mitochondria, spindle and protein metabolism in mouse oocytes
Authors: Zhang Chuanxin , Dong Xueqi , Yuan Xinyi , Song Jinzhu , Wang Jiawei , Yin Xiaoyu , Hou Zhenzhen , Li Cheng , Ma Shuiying , Chen Zi-Jiang , Wu Keliang 
Published: September 2023

In brief
Post-ovulatory aging (POA) results in a decline in oocyte quality and embryonic developmental capacity although the underlying mechanisms remain elusive. This study provides comprehensive mRNA expression profiles of fresh and aging oocytes in mice for the first time.

Abstract
POA impairs the quality of mammalian oocytes with harmful effects on the developmental potential of the embryo. This is a major problem for humans since it is associated with low rate of natural fertility, with high rate of spontaneous abortion and low efficiency of in vitro fertilization. However, the molecular mechanisms underlying this process remain unclear and new methods are demanded to control POA. In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis on fresh and aging MII mouse oocytes and compared their global RNA transcription patterns. Nine hundred and twenty-one differentially expressed genes (DEGs) were identified. Five hundred and sixty-nine genes were downregulated, while 356 were upregulated in the group of aging oocytes. Gene ontology (GO) enrichment analysis demonstrated that a series of DEGs were significantly enriched involving mitochondrial functions, spindle functions and protein metabolism. The results of qPCR and a series of functional tests further confirmed that the disorder of mitochondrial functions, spindle functions and impairment of protein metabolism were actually involved in the progression of POA. In this study, panoramic mRNA expression profiles of fresh and aging oocytes were depicted and fully validated. Our data will provide a useful resource for further research on the regulation of gene expression of POA and suggest potential strategies to delay and reverse POA.
TEORINĖ PRIEIGA: EUROPEIZACIJA, ELITAI, VALSTYBĖS UŽGROBIMAS IR VYSTYMASIS
Authors: MANIOKAS KLAUDIJUS 
Published: September 2023

The aim of the paper is to present conceptual framework used to assess Europeanization in Lithuania during the last 10 years across the classical to Europeanization literature dimensions of polity, politics and policy. In the article author reviews Europeanization literature, the main approaches as well as their critique and weak points. Author argues that because usually consequences of Europeanization are fragmented and hardly possible to generalize, therefore, it is wise to look at the new EU member states, where this impact was concentrated. The latest Europeanization literature, however,mostly critically views the very concept of Europeanization, especially because of its inability to include factors of domestic politics. Transitology approach also has certain drawbacks which cannot explain changes in the new EU members. Thus, it is argued by the author that Europeanization theory has to be complemented by additional approaches accounting for a domestic change. Therefore, Europeanization is put into a broader development studies. The theory of development produced by Douglass C. North, John Joseph Wallis and Barry R. Weingast serves as theoretical framework in the research. This theory is about a long-term change based on depatrimonialization of a given society and move from the so-called natural state characterized by the use of rents into an open access regime characterized by universal rights, competition, wide use of public goods and density of organizations. This developmental approach puts an emphasis on the role of elites, state capture and broader transformation of the society and thus focuses and complements the current theory of Europeanization. It also provides a framework to analyse the issue of corruption and state capture, which is no longer considered as a deviation, but rather as a norm.
A Morbid Kíváncsiság Skála magyar nyelvű változatának adaptációja
Authors: Kiss Botond László , Bali Cintia , Basler Julia , Fehér Adrián , Zsidó András Norbert 
Published: September 2023

Háttér és célkitűzésekAz erőszakos, kellemetlen vagy halálhoz köthető tartalmak iránti érdeklődés a morbid kíváncsiság mértékével jellemezhető. Az ilyen tartalmak általában félelmet, undort, illetve elkerülő viselkedést váltanak ki, ugyanakkor egyes embereket a kiváltott arousal emelkedés miatt mégis vonzanak. A jelenség részletesebb feltárásával pontosabb képet kaphatunk arról, milyen tényezők játszanak szerepet olyan specifikus fóbiák esetén, ahol mind az undor, mind pedig a félelem releváns érzelmi reakció. A jelen tanulmány célja a Morbid Kíváncsiság Skála pszichometriai elemzése egy megfelelően nagy és az életkor szempontjából diverz magyar anyanyelvű mintán.MódszerA kutatás során összesen 592 fő (442 nő, 150 férfi) töltötte ki a kérdőívcsomagot. A kitöltők átlagéletkora 34,2 év (SD: 10,64; terjedelem: 18–73 év). A Morbid Kíváncsiság Skála mellett a résztvevők a Szenzoros Élménykereséses Skálát és az Undorérzékenység Skálát töltötték ki. A Morbid Kíváncsiság Skála pszichometriai mutatóit klasszikus és modern tesztelméleti eljárásokkal is ellenőriztük.EredményekA Morbid Kíváncsiság Skála megfelelő pszichometriai mutatókkal rendelkezik a vizsgált magyar mintán. A kérdőív tételei megfelelően diszkriminálnak a látens változó különböző szintjeivel rendelkező kitöltők között, és a kérdőív megbízhatóan mér az átlaghoz viszonyított kétszeres szórástartományban. A kérdőív összpontszáma és alskáláinak pontszámai pozitív irányú összefüggést mutattak a szenzoros élménykereséssel, míg az összpontszám, az Erőszak és a Test megsértése alksálák pedig az undorérzékenységgel mutattak negatív irányú kapcsolatot.KövetkeztetésekMindent összevetve eredményeink alapján a Morbid Kíváncsiság Skála magyar mintán is megbízható és érvényes kérdőív. A kérdőív releváns eszköz lehet kellemetlen vagy undorító tartalmakhoz való viszonyulás mérésére, a megközelítő-elkerülő viselkedéses rendszer vizsgálatára; mind kutatások, mind pedig terápiák során utánkövetésre.
Design and optimization of an improved qPCR assay for the detection of Histoplasma capsulatum
Authors: da Silva Bianca Kelly Neves Izidro , Alves Cortez Ana Cláudia , Oliveira Luciana Aires , de Almeida Juan Diego Ribeiro , de Souza Érica Simplício , Cruz Katia Santana , Jackisch Matsuura Ani Beatriz , Ogusku Mauricio Morishi , Solórzano Chavarría Karolina Jeaneth , Baía-da-Silva Djane , Bassat Quique , Guimarães Lacerda Marcus Vinícius , Frickmann Hagen , de Souza João Vicente Braga 
Published: September 2023

AbstractBackgroundThis study aimed at improving a real-time polymerase-chain-reaction (qPCR) assay for the detection of Histoplasma capsulatum, a fungal pathogen that can cause severe respiratory infections in humans, in clinical and soil samples.MethodsPrimer and probes were in-silico designed, in-silico and in-vitro evaluated including clinical biopsy materials and finally subjected to a real-world application with collected soil samples.ResultsApplying the qPCR assay with liver and lung biopsies from 71 patients each, including 59 patients infected with human immunodeficiency virus (HIV), as well as with Sabouraud (SAB) agar culture as the diagnostic reference standard, diagnostic accuracy of the qPCR assay of 100% (5/5) sensitivity and 96% (63/66) specificity for liver samples and 100% (4/4) sensitivity and 94% (63/67) specificity for the lung samples was recorded. When applying the assay with soil samples from caves near of Presidente Figueiredo city, Amazonas, Brazil, one sample from the Maroaga cave was confirmed as positive.ConclusionsThe improved qPCR assessed in this study was successful in detecting H. capsulatum with high efficiency and accuracy in in-vitro evaluation, including the identification of the target pathogen in both clinical and environmental samples.
Psychedelics and critical theory
Authors: Tempone-Wiltshire Julien , Dowie Tra-ill 
Published: September 2023

AbstractIn the monograph Philosophy and Psychedelics: Frameworks for Exceptional Experience, Hauskeller raises the important subject of individualization and alienation in psychedelic psychotherapy. Under the prevailing conditions of neoliberalism, Hauskeller contends that psychedelic-assisted psychotherapy appropriates Indigenous knowledges in an oppressive fashion, may be instrumentalised to the ends of productivity gain and symptom suppression, and may be utilised to mask societal systems of alienation. Whilst offering a valuable socio-political critique of psychedelics' clinical uptake, we suggest that Hauskeller's view does not adequately acknowledge the ways in which psychedelics offer a challenge to the Western reductive bio-medical understanding of healing and wellbeing. It is contended herein that Indigenous knowledges, in alliance with a range of emerging sciences, offer both an engagement with ethnomedicines in a less harmfully appropriative fashion, and a renewed understanding of the means by which psychedelics achieve therapeutic change. With this understanding, what becomes apparent are the potential ways in which psychedelic medical usage may produce positive feedback upon the oppressive systems in which we are embedded. That is, transpersonal experience through encounters with the ineffable may offer a revisioning of Western psychology and cognitive science. Indeed, if psychedelics are approached with an understanding of the actual means by which they produce therapeutic outcomes—changing mental representations of the self, or self-insight derived through non-ordinary states of consciousness—then psychedelic psychotherapy offers a reimagining of psychiatric nosology, challenging conventional understandings of both pathology and wellbeing through an overturning of specified and discrete deficit models of psychopathology. This may provide both a critique of the prevailing categories used to describe madness and an expansion of our understanding of the mind-body relation, as well as an increased recognition of positive psychology grounded in cross-cultural contemplative traditions. This provides an implicit challenge to the pharmaceutical industrial-complex and its profit motives; and the corresponding neoliberalist, globalising tendencies which Hauskeller seeks to address.
Do we pay more attention to the label that is considered more expensive? Eye-tracking analysis of different wine varieties
Authors: Szakál Dorina , Fekete-Frojimovics Zsófia , Bin Zulkarnain Abdul Hannan , Rozgonyi Erik , Fehér Orsolya 
Published: September 2023

AbstractIn our study, using a combination of eye-tracking parameter analysis and the van Westendorp method, we investigate whether participants pay more attention to products that they perceive as more expensive or to those that they prefer in the ranking process. The experiment involved 50 participants, a questionnaire with ranking and pricing tasks, and an eye-tracking measurement. Three wine varieties (Irsai Olivér, Rosé and Merlot-Shiraz) and three different label alternatives were tested. When comparing the results of the ranking and the pricing tasks, the product that is considered more expensive is not always the one that is most appealing to the participants. If we compare the results from the analysis of the eye-tracking parameters and the pricing, we can say that in all cases the labels that received the most visual attention were those that were priced more expensively by the participants.
Crossbar operation of BiFeO3/Ce–CaMnO3 ferroelectric tunnel junctions: From materials to integration
Authors: Halter Mattia , Morabito Elisabetta , Olziersky Antonis , Carrétéro Cécile , Chanthbouala André , Falcone Donato Francesco , Offrein Bert Jan , Bégon-Lours Laura 
Published: September 2023

AbstractFerroelectric Tunnel Junctions (FTJs) are a candidate for the hardware realization of synapses in artificial neural networks. The fabrication process for a 784 × 100 crossbar array of 500 nm large FTJs, exhibiting effective On/Off currents ratio in the range 50–100, is presented. First, the epitaxial 4 nm-BiFeO3/Ca0.96Ce0.04MnO3//YAlO3 is combined with Ni electrodes. The oxidation of Ni during the processing affects the polarity of the FTJ and the On/Off ratio, which becomes comparable to that of CMOS-compatible HfZrO4 junctions. The latter have a wider coercive field distribution: consequently, in test crossbar arrays, BiFeO3 exhibits a smaller cross-talk than HfZrO4. Furthermore, the relatively larger threshold for ferroelectric switching in BiFeO3 allows the use application of half-programming schemes for supervised and unsupervised learning. Second, the heterostructure is combined with W and Pt electrodes. The design is optimized for the controlled collapse chip connection to neuromorphic circuits.
Graphical abstract
Disparities in Food Security and Glycemic Control Among People with Type 2 Diabetes During the COVID-19 Pandemic
Authors: Tran Thanh , Cristello Sarteau Angelica , Fogleman Cy , Young Laura Anne , Mayer-Davis Elizabeth 
Published: September 2023

Background Little is known about the differing impacts of food insecurity on HbA1c by race in type 2 diabetes (T2D). Predictions around increased food insecurity from COVID-19 exacerbating racial disparities led us to estimate its prevalence and associations with HbA1c by race during the COVID-19 pandemic. Methods Data came from medical records and surveys among a clinic-based sample of T2D patients. Linear regression models estimated associations between food insecurity and HbA1c and between change in food insecurity and change in HbA1c. Likelihood ratio tests and examination of stratum-specific estimates assessed effect modification by race. Results Our sample was 59% White, 59% female, and mean age was 60.8 ± 12.6. During the pandemic, food insecurity prevalence and HbA1c were significantly (p < .05) higher among non-Whites (39%, 8.4% ± 2.1) compared to Whites (15%, 7.8% ±1.6). HbA1c among those who were very food insecure was 1.00% (95% CI: 0.222, 1.762, p = .01) higher than those who were food secure. Those with increased food insecurity had a 0.58% (95% CI: 0.024, 1.128, p = .04) higher HbA1c increase than among those experiencing no change. No effect modification was detected. Limitations Convenience sampling in an endocrinology clinic, recall bias, and inadequate power may underlie null effect modification results. Conclusion Although effect modification was not detected, racial disparities in HbA1c and food insecurity warrant further investigation. These disparities, combined with the significant impact of food insecurity on HbA1c, suggest that prioritization of resources to high-risk populations should be considered early during public emergencies to minimize short- and long-term health consequences.
EARLY DETECTION OF TUBERCULOSIS APPLICATION (E-TIBI): A NEW PARADIGM TO DETECT NEW CASE OF TUBERCULOSIS
Authors: Astha Triyono Erwin , Mahanani MVS , Anggraini Sulvy Dwi , Maulana Hafidh , Pratiwi Wahyu Dian , Yochanan Christian , Tan Feriawan , Masyfufah Lilis 
Published: September 2023

Background: Tuberculosis (TB) is still one of the major health problems in the world, especially in countries with dense populations. Indonesia is listed among the top three countries with the highest burden of tuberculosis worldwide. The low coverage of case detection in Indonesia is one of the reasons for ineffective TB control. Therefore, this disease remains a threat to spread in today’s Indonesian society. Digital technology can be used to increase the effectiveness and efficiency of case detection. This study aims to create a new paradigm for detecting new cases of tuberculosis using a self-assessment website-based application. Methods: This descriptive quantitative research used univariate analysis. Respondents for this research were sampled from all East Java people who filled out the E-TIBI application. Result: In total, there were 4,658 E-TIBI users in East Java, with 20.80% suspected of tuberculosis. The most frequent symptoms found in the respondents were fatigue, cough for > 2 weeks, and weight loss. Discussion: A self-assessment paradigm based on digital technology was applied to the design of this E-TIBI application. From this application, the public can quickly determine whether they or others are suspected of having tuberculosis. This result shows that the whole community can easily access the E-TIBI application for initial tuberculosis screening. Conclusion: Through this application, direct community participation can increase the detection of new cases to support the government and WHO programs in eliminating tuberculosis by 2030.
ADOLESCENT KNOWLEDGE AND PERCEPTION OF HIV/ AIDS STIGMATIZATION IN THE INDONESIAN CONTEXT
Authors: Maris Bakara Stella , Sahara Lubis Elvi , Fitriani Yessy 
Published: September 2023

Background: Stigmatization of People Living with HIV/AIDS (PLWHA) among adolescents today has become a significant barrier to preventing the increase of HIV/AIDS cases, including understanding those at risk and PLWHA themselves. Adolescents' knowledge and perceptions about PLWHA significantly influence HIV/AIDS stigma, given that adolescence signifies a phase of profound biological, psychological, and social transition. Objective: This research aims to determine the correlation between knowledge and perception of the stigma against people living with HIV/AIDS. Methods: This study utilizes secondary data from the Indonesian Demographic and Health Survey (IDHS) 2017, analyzed using a cross-sectional method. The sample consisted of 14,270 adolescents in Indonesia aged 15 to 24 years. The study employed questionnaires on HIV/AIDS knowledge, perception towards PLWHA, and stigma towards PLWHA. Data analysis was conducted using univariate analysis to observe frequency distribution and bivariate analysis with a chi-square test to examine the relationship between two variables. Results: The research results indicate a significant correlation between adolescents' knowledge and stigma towards PLWHA at 0.00 (p<0.05), as well as a significant correlation between adolescents' perception and stigma towards people with HIV/AIDS at 0.00 (p<0.05). Conclusion: Prevention efforts through education and comprehensive approaches in delivering health information in a way that is well-received by adolescents can be presented innovatively.
RISK FACTORS FOR THE INCIDENCE OF ANEMIA IN YOUNG WOMEN
Authors: Simatupang Nanda Agustian , Kalsum Ummi , Fitri Adelina , Agustia Dilma’aarij 
Published: September 2023

Background: The prevalence of anemia in adolescents is still high in Jambi Province at 60.45%. Anemia can cause a decrease in body resistance and fitness, thereby inhibiting adolescent productivity. Purpose: Research objectives to determine the prevalence of anemia and risk factors for the incidence of anemia in young women. Methods: Cross-sectional research design, located in State Senior High School 8 of Jambi City from January to April 2019. Population 552 girls, with a sample of 83 girls in classes X and XI. The proportioned stratified random sampling technique was taken. The research variables were knowledge, breakfast, tablets, blood consumption, nutritional status, enhancing foods and iron absorption inhibitors, infectious diseases, and heavy meal frequency. The dependent variable was anemia. Interviews and secondary data from the measurement of Hb were conducted for primary data collection. Data would be analyzed with chi-square analysis. Results: The incidence of anemia among young women was 42.17%. There was relationship of knowledge (PR=2.05; 95% CI=1.30-3.24), blood tablet supplementation (PR=2.95; 95% CI =1.02-8.54), Breakfast (PR=3.03; 95% CI=1.41-6.48), and frequency of heavy eating (PR = 0.52; 95% CI=0.28-0.97) with the incidence of anemia. Conclusion: Factors associated with anemia among young women are knowledge, consumption of tablets plus blood, breakfast, and frequency of heavy eating.
DIGNIDADE, DIREITOS E CUIDADO: UMA LEITURA ECOTEOLÓGICA
Authors: Murad Afonso , Susin Luiz Carlos 
Published: September 2023

Constatada a urgência ecológica de uma nova relação do ser humano com as outras criaturas, o artigo busca compreender a constituição de direitos e, na sua base, a categoria de dignidade. Para tanto, analisa a linguagem sobre a dignidade e um percurso histórico sobre a ampliação de reconhecimento de dignidade e direitos humanos. A partir dos animais, testa um reconhecimento alargado desses dois conceitos cada vez mais assimétricos. Dessa forma, a relação se transforma na gratuidade e na responsabilidade do Cuidado, assimétrico e interdependente, que configura, assim, um novo humanismo ecológico. Com Leonardo Boff e o Papa Francisco, o artigo sublinha as consequências dessa postura e os elementos teológico-pastorais de prática cristã do Cuidado.
PALAVRAS-CHAVE: Direitos humanos. Humanismo. Ecologia. Cuidado.