bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving short text classification with augmented data using GPT-3
Authors: Balkus Salvador V. , Yan Donghui 
Published: August 2023

AbstractGPT-3 is a large-scale natural language model developed by OpenAI that can perform many different tasks, including topic classification. Although researchers claim that it requires only a small number of in-context examples to learn a task, in practice GPT-3 requires these training examples to be either of exceptional quality or a higher quantity than easily created by hand. To address this issue, this study teaches GPT-3 to classify whether a question is related to data science by augmenting a small training set with additional examples generated by GPT-3 itself. This study compares two augmented classifiers: the Classification Endpoint with an increased training set size and the Completion Endpoint with an augmented prompt optimized using a genetic algorithm. We find that data augmentation significantly increases the accuracy of both classifiers, and that the embedding-based Classification Endpoint achieves the best accuracy of about 76%, compared to human accuracy of 85%. In this way, giving large language models like GPT-3 the ability to propose their own training examples can improve short text classification performance.
How effective were government food box schemes for those who were shielding during the first wave of the COVID-19 pandemic in the United Kingdom? Local and national stakeholder perspectives
Authors: Lambie-Mumford Hannah , Loopstra Rachel , Gordon Katy 
Published: August 2023

AbstractObjective:In spring 2020, governments across the UK put in place food box schemes to protect access to food for the population told to ‘shield’ from COVID-19 (i.e. not leave their house for any reason). This article explores the design, implementation and impact of food box schemes intended to regularly provide a week’s worth of food for individuals who were shielding.Design:Interviews and workshops with national and local stakeholders over summer 2020 to autumn 2021.Setting:England, Northern Ireland, Scotland and Wales.Participants:National and local government and NGO stakeholders involved in food response during the COVID-19 pandemic.Results:Local authorities played a crucial role, implementing and supplementing the national provision of food box schemes. Three key shortcomings of the schemes were identified: coverage, contents and accessibility. In England and Wales, the scheme only provided food for shielding individuals, not their household members. Across the schemes, box contents were criticised for not containing sufficient amounts of fresh or healthy food and for not being able to meet individual dietary requirements. They were also inaccessible for people who required support with lifting or preparing food.Conclusions:The inadequacy of shielding food box schemes may have undermined people’s ability to shield during the first UK lockdown. The COVID-19 pandemic required rapidly implemented policy responses, but these findings underscore the importance of universal provision and nutrition, physical accessibility and cultural food needs when formulating public health nutrition interventions.
The effects of illness perception on death anxiety and satisfaction with life in patients with advanced gastrointestinal cancer
Authors: Bahçecioğlu Turan Gülcan , Türkben Polat Hilal 
Published: August 2023

AbstractObjectivesThis study was conducted to determine the effects of illness perception on death anxiety and satisfaction with life in patients with advanced gastrointestinal cancer.MethodsThis cross-sectional and correlational study was conducted with 125 patients with cancer who were admitted to the oncology clinic of a university hospital in the Central Anatolian Region of Turkey between March and December 2022 and who met the research criteria and accepted to participate in the study. The data were collected with “Patient descriptive information form,” “Brief Illness Perception Questionnaire (BIPQ),” “Scale of Death Anxiety (SDA),” and “Satisfaction with Life Scale (SWLS).”ResultsIt was found that mean BIPQ score of the patients was 39.54 ± 12.82, the mean SDA score was 8.02 ± 3.16, and the mean SWLS score was 14.74 ± 5.19. BIPQ total score was found to affect SDA total score positively (β = .751) and SWLS total score negatively (β = − .591). SDA total score was found to affect SWLS total score negatively (β = −.216) (p < .05).Significance of resultsIt was found that patients with advanced gastrointestinal cancer had moderate level of illness perception and life satisfaction, and high death anxiety. It was found that as illness perception of the patients increased, their death anxiety increased and satisfaction with life decreased. In addition, it was found that as the death anxiety of patients increased, their satisfaction with life decreased.
Rethinking colonialism through early modern global diplomacy: A tale of Pampangan mobility
Authors: Tremml-Werner Birgit 
Published: August 2023

AbstractThis study is an intervention in early modern global diplomacy. Integrating an indigenous community of the Philippines into foreign relations and maritime connections, the article reevaluates the complex story of the Pampangans of Luzon, allegedly long-term allies of the Spanish conquerors, and the narrative of indigenous collaboration. Foregrounding the Pampangans’ involvement in military campaigns, as well as territorial and maritime expansion in the early decades of the 1600s, the article introduces three scenarios of Pampangan power bargaining with global consequences. The focus on Pampangan foreign relations opens new analytical perspectives on the role of language and knowledge for internal coloniality on the one hand, foreign and diplomatic negotiations on the other. Methodologically, it proposes a deep (re-)reading of the polyvocal archive of the colonial-indigenous encounter and integrates insights with the largely separated scholarship of diplomatic and indigenous history as a new avenue in global history.
Dieu dans la commune: religion and voting in the 2017 French election
Authors: Overos Henry David , Sauer Jeffery 
Published: August 2023

AbstractEuropean political parties, particularly radical right parties (RRPs), increasingly use religious symbols during elections. Despite the prevalence of these symbols, evidence on the association between religion and far-right vote share is mixed. We compare two leading arguments explaining the relationship between religion and RRPs. We hypothesize that the number of religious buildings, identifiable as Islamic or Catholic, will be associated with higher RRP support. We test this as a most likely crucial case using results from the French 2017 presidential election. Controlling for other demographic factors, more Catholic buildings in a commune are associated with a decrease in votes for the Front Nationale (FN). An increase in the number of mosques in non-urban communes is associated with increased support for FN. We argue these findings are evidence that RRPs use religious symbolism to draw on nativist or anti-Islamic support rather than traditional religious support.
Social rights scapegoating
Authors: Chilton Adam , Eyzaguirre Cristián , Versteeg Mila 
Published: August 2023

AbstractIn Chile, many commentators, academics and political leaders have spent years arguing that the limited nature of the social rights in the national constitution is partially responsible for the country’s economic and social inequality. It is thus unsurprising that changing the scope of the country’s social rights was a major focus of the recently failed constitutional reform effort. However, we argue that the long-running claim that Chile’s social problems were due to the limited nature of social rights can be thought of as social rights scapegoating, by which we mean that commentators blamed outcomes on constitutional rights, even though there is little evidence that countries’ socio-economic outcomes are a product of their social rights.
Yesterday's High Tide Is Today's New Normal
Authors: Piecuch Christopher G. , Hamlington Benjamin D. 
Published: August 2023

AbstractThe daily rise and fall of the tides are intimately familiar to those living on the coast. However, due to sea‐level rise, what communities in the United States now experience as the highest, lowest, and average water levels on a typical day no longer corresponds to the official definitions of high tide, low tide, and mean sea level, respectively. Water levels now regularly exceed official high tide along parts of the Chesapeake Bay, Gulf Coast, and Puerto Rico. In other words, yesterday's high tide is becoming today's new normal. This demonstrates how sea‐level rise is radically redefining the American shore.
Renewed Epicentral Distribution of Low Frequency Marsquakes by Varying‐Parameter Polarization Analysis of InSight Data
Authors: Wang Xu , Chen Ling , Wang Xin 
Published: August 2023

AbstractAccurate information about marsquake locations is crucial for understanding the tectonic activity, subsurface structures, and dynamics of Mars. We designed a varying‐parameter scheme for polarization analysis to determine the back‐azimuths of marsquakes. For two Martian meteorite impact events with ground‐truth locations known from orbital images, our scheme yields back‐azimuths that are ∼5° and ∼14° closer to the true values than those reported previously, demonstrating our method's advantages in constraining back‐azimuths. We applied this method to determine the back‐azimuths of 44 Low Frequency marsquakes and 39 were reliably relocated. Nearly half of these marsquakes occur in Cerberus Fossae, while the rest are broadly distributed, including along the dichotomy boundary and within the northern lowlands and southern highlands. Although further studies are required to understand the mechanisms of these marsquakes, the widespread seismicity implies that present‐day Mars, especially the ancient southern highlands, is more tectonically active than previously thought.
A New GRACE Filtering Approach Based on Iterative Image Convolution
Authors: Zhou Hao , Wang Penghui , Tang Lu , Luo Zhicai 
Published: August 2023

AbstractThe Gravity Recovery and Climate Experiment (GRACE) mission and its successor GRACE Follow‐On (GRACE‐FO) mission provide humans with a unique perspective on mass distribution through accurate temporal gravity field models. However, these models suffer from unavoidable stripe errors in the spatial domain. A new approach based on image processing has been developed for filtering GRACE and GRACE‐FO spherical harmonic solutions. In this approach, the gravity fields are treated as noise‐contaminated images, and the stripe errors are expected to be suppressed by convolving the input with an appropriate kernel. To verify the effectiveness of the proposed approach, a closed‐loop simulation environment over the nominal mission lifetime of 5 years is designed. Image processing indicators and geophysical information evaluation results demonstrate the superior performance of the new approach in suppressing stripe errors. In the context of real GRACE data processing, our new approach still yields better results as follows: (a) The comprehensive ability of de‐striping and retaining details has slight advantages over some commonly used filters, as demonstrated through spatial distributions, amplitude spectra, and coefficient spectra. (b) The equivalent water height time series at the basin scale is comparable to the results derived from other filters or Level‐3 products. (c) The estimated signal amplitude of the Mw9.1 2004 Sumatra earthquake co‐seismic gravity change is 52.7% larger than that derived from the Gaussian 300 km filter, which is much closer to the theoretical value derived from the dislocation theory.
Estuarine Hypoxia—Identifying High Risk Catchments Now and Under Future Climate Scenarios
Authors: Waddington K. , Harrison A. , Rayner D. , Tucker T. , Glamore W. 
Published: August 2023

AbstractHypoxic blackwater events occur worldwide, affecting inland and coastal waters. These events have been exacerbated by man‐made floodplain drainage, leading to large‐scale fish kills and ecological degradation. This paper presents a new method to identify estuarine catchment areas that are most likely to generate hypoxic conditions. The method uses established risk factors, including vegetation type, inundation extent and duration, ground‐truthed in eastern Australia. A catchment is at higher risk of hypoxic blackwater generation if (a) it is located where floodwaters are high and/or drainage is impeded, (b) the site topography includes an extensive, low‐lying floodplain; and/or (c) the land‐use and environmental characteristics have a high deoxygenation potential. Consequent impacts to an estuary are determined by the floodplain connectivity with the estuary, and the discharge characteristics of the catchment drainage system. Where multiple, proximate catchments have similar drainage conditions, compounding plumes of hypoxic blackwater can overwhelm the assimilation capacity of the estuary. Climate change may significantly increase the volume and frequency of blackwater events in estuarine environments as a result of reduced drainage due to sea level rise, higher temperatures, and more intense and sporadic rainfall events. It is recommended that management measures be introduced to mitigate the effects of climate change and avoid further widespread hypoxic blackwater events.
Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice
Authors: Bi Ruiye , Li Qianli , Li Haohan , Wang Peng , Fang Han , Yang Xianni , Wang Yiru , Hou Yi , Ying Binbin , Zhu Songsong 
Published: August 2023

AbstractThe anterior disc displacement (ADD) leads to temporomandibular joint osteoarthritis (TMJOA) and mandibular growth retardation in adolescents. To investigate the potential functional role of fibrocartilage stem cells (FCSCs) during the process, a surgical ADD-TMJOA mouse model was established. From 1 week after model generation, ADD mice exhibited aggravated mandibular growth retardation with osteoarthritis (OA)-like joint cartilage degeneration, manifesting with impaired chondrogenic differentiation and loss of subchondral bone homeostasis. Lineage tracing using Gli1-CreER+;Tmfl/-mice and Sox9-CreER+;Tmfl/-mice showed that ADD interfered with the chondrogenic capacity of Gli1+ FCSCs as well as osteogenic differentiation of Sox9+ lineage, mainly in the middle zone of TMJ cartilage. Then, a surgically induced disc reposition (DR) mouse model was generated. The inhibited FCSCs capacity was significantly alleviated by DR treatment in ADD mice. And both the ADD mice and adolescent ADD patients had significantly relieved OA phenotype and improved condylar growth after DR treatment. In conclusion, ADD-TMJOA leads to impaired chondrogenic progenitor capacity and osteogenesis differentiation of FCSCs lineage, resulting in cartilage degeneration and loss of subchondral bone homeostasis, finally causing TMJ growth retardation. DR at an early stage could significantly alleviate cartilage degeneration and restore TMJ cartilage growth potential.
Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn
Authors: Timberline Sage , Bhatt Avni , Sunderji Sherzana , Tancredi Daniel J. , Lakshminrusimha Satyan , Siefkes Heather 
Published: August 2023

Abstract
Objective
To obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent pulmonary hypertension of the newborn (PPHN).

Study design
Retrospective chart review of 100 consecutive neonates admitted to a Children’s hospital from 2016–2021 with PPHN, gestational age ≥34 weeks, and echocardiograms in the first week. We assessed the correlation between HRF/PH score and short-term outcomes using linear and logistic regressions.

Results
HRF/PH scores ranged 2–12 (mean 8.5), and were classified mild (0–5), moderate (6–10), and severe (11–15), with 6%, 77% and 17% infants in respective categories. HRF/PH score category correlated with invasive ventilation, nitric oxide, high frequency ventilation, vasoactive infusions, extracorporeal life support and death. HRF/PH score category did not correlate with duration of support or length of stay.

Conclusion
The HRF/PH score offers a promising representation of disease severity for PPHN. The tool requires further validation in prospective studies and evaluation for long-term outcomes.
Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation
Authors: Luo Jiao , Song Ge , Chen Ningning , Xie Mengyue , Niu Xuan , Zhou Shuyue , Ji Yanan , Zhu Xiaoxiao , Ma Wanli , Zhang Qianqian , Yu Dianke 
Published: August 2023

AbstractAlcohol abuse is a significant cause of global morbidity and mortality, with alcoholic liver disease (ALD) being a common consequence. The pathogenesis of ALD involves various cellular processes, including oxidative stress, inflammation, and hepatic cell death. Recently, ferroptosis, an iron-dependent form of programmed cell death, has emerged as a potential mechanism in many diseases. However, the specific involvement and regulatory mechanisms of ferroptosis in ALD remain poorly understood. Here we aimed to investigate the presence and mechanism of alcohol-induced ferroptosis and the involvement of miRNAs in regulating ferroptosis sensitivity. Our findings revealed that long-term ethanol feeding induced ferroptosis in male mice, as evidenced by increased expression of ferroptosis-related genes, lipid peroxidation, and labile iron accumulation in the liver. Furthermore, we identified dysregulation of the methionine cycle and transsulfuration pathway, leading to severe glutathione (GSH) exhaustion and indirect deactivation of glutathione peroxidase 4 (GPx4), a critical enzyme in preventing ferroptosis. Additionally, we identified miR-214 as a ferroptosis regulator in ALD, enhancing hepatocyte ferroptosis by transcriptionally activating the expression of ferroptosis-driver genes. Our study provides novel insights into the involvement and regulatory mechanisms of ferroptosis in ALD, highlighting the potential therapeutic implications of targeting ferroptosis and miRNAs in ALD management.
BRD7 suppresses tumor chemosensitivity to CHK1 inhibitors by inhibiting USP1-mediated deubiquitination of CHK1
Authors: Li Lemin , Wang Linchen , Liu Dian , Zhao Yongchao 
Published: August 2023

AbstractCheckpoint kinase 1 (CHK1), a key effector in the cellular response to DNA lesions, is a crucial component of all cell cycle checkpoints. Recent reports have revealed that CHK1 is highly expressed in numerous cancer types in the clinical settings. However, the mechanisms underlying the regulation of CHK1 expression in tumor cells remain unclear. Here, we report that CHK1 is negatively regulated by the bromodomain-containing protein 7 (BRD7). Specifically, BRD7 silencing increased CHK1 (but not CHK2) expression at both mRNA and protein levels, in a p53-independent manner in multiple tumor cell lines. Furthermore, BRD7 silencing stabilized CHK1 via reducing its ubiquitination. Mechanistically, BRD7 knockdown not only increased the levels of USP1, a deubiquitinase for CHK1, but also promoted the interaction between CHK1 and USP1, subsequently enhancing the de-ubiquitination of CHK1. USP1 knockdown abrogated BRD7 silencing-induced CHK1 induction. Biologically, the increased expression of CHK1 in tumor cells caused by BRD7 silencing significantly increased cell sensitivity to CHK1 inhibitors by enhancing tumor cell apoptosis, and this effect was reversed by the simultaneous knockdown of CHK1 or USP1. Taken together, our findings suggest that BRD7 is a potential genetic or drug target that may help to improve the efficacy of chemotherapeutic drugs targeting CHK1 in combinatorial therapy.
Suppressed Akt/GSK-3β/β-catenin signaling contributes to excessive adipogenesis of fibro-adipogenic progenitors after rotator cuff tears
Authors: Lin Xingzuan , Wang Peng , Wang Wei , Zhou Hao , Zhu Siyuan , Feng Shujing , Chen Yuzhou , Zhou Han , Wang Qichao , Xin Hanlong , Shao Xiexiang , Wang Jianhua 
Published: August 2023

AbstractMuscular fatty infiltration is a common and troublesome pathology after rotator cuff tears (RCT), which mainly derives from fibro-adipogenic progenitors (FAPs). Compared to the RCT, fatty infiltration is not so severe in Achilles tendon tears (ATT). The knowledge of why fatty infiltration is more likely to occur after RCT is limited. In this study, more severe fatty infiltration was verified in supraspinatus than gastrocnemius muscles after tendon injury. Additionally, we revealed higher adipogenic differentiation ability of RCT-FAPs in vitro. Activation of Akt significantly stimulated GSK-3β/β-catenin signaling and thus decreased PPARγ expression and adipogenesis of RCT-FAPs, while the inhibition effect was attenuated by β-catenin inhibitor. Furthermore, Wnt signaling activator BML-284 limited adipogenesis of RCT-FAPs, alleviated muscular fatty infiltration, and improved parameters in gait analysis and treadmill test for RCT model. In conclusion, our study demonstrated that suppressed Akt/GSK-3β/β-catenin signaling increased PPARγ expression and thus contributed to excessive adipogenesis in RCT-FAPs. Modulation of Akt/GSK-3β/β-catenin signaling ameliorated excessive fatty infiltration of rotator cuff muscles and improved shoulder function after RCT.
Combination human umbilical cord perivascular and endothelial colony forming cell therapy for ischemic cardiac injury
Authors: Iqbal Farwah , Johnston Alexander , Wyse Brandon , Rabani Razieh , Mander Poonam , Hoseini Banafshe , Wu Jun , Li Ren-Ke , Gauthier-Fisher Andrée , Szaraz Peter , Librach Clifford 
Published: August 2023

AbstractCell-based therapeutics are promising interventions to repair ischemic cardiac tissue. However, no single cell type has yet been found to be both specialized and versatile enough to heal the heart. The synergistic effects of two regenerative cell types including endothelial colony forming cells (ECFC) and first-trimester human umbilical cord perivascular cells (FTM HUCPVC) with endothelial cell and pericyte properties respectively, on angiogenic and regenerative properties were tested in a rat model of myocardial infarction (MI), in vitro tube formation and Matrigel plug assay. The combination of FTM HUCPVCs and ECFCs synergistically reduced fibrosis and cardiomyocyte apoptosis, while promoting favorable cardiac remodeling and contractility. These effects were in part mediated by ANGPT2, PDGF-β, and VEGF-C. PDGF-β signaling-dependent synergistic effects on angiogenesis were also observed in vitro and in vivo. FTM HUCPVCs and ECFCs represent a cell combination therapy for promoting and sustaining vascularization following ischemic cardiac injury.