bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alleviative effects of pinostrobin against cadmium-induced renal toxicity in rats by reducing oxidative stress, apoptosis, inflammation, and mitochondrial dysfunction
Authors: Ijaz Muhammad Umar , Shahzadi Sabahat , Hamza Ali , Azmat Rabia , Anwar Haseeb , Afsar Tayyaba , Shafique Huma , Bhat Mashooq Ahmad , Naglah Ahmed M. , Al-Omar Mohamed A. , Razak Suhail 
Published: May 2023

IntroductionCadmium (Cd) is a highly toxic heavy metal that can be found everywhere in the environment and can have harmful effects on both human and animal health. Pinostrobin (PSB) is a bioactive natural flavonoid isolated from Boesenbergia rotunda with several pharmacological properties, such as antiinflammatory, anticancer, antioxidant, and antiviral. This investigation was intended to assess the therapeutic potential of PSB against Cd-induced kidney damage in rats.MethodsIn total, 48 Sprague Dawley rats were divided into four groups: a control, a Cd (5 mg/kg), a Cd + PSB group (5 mg/kg Cd and 10 mg/kg PSB), and a PSB group (10 mg/kg) that received supplementation for 30 days.ResultsExposure to Cd led to a decrease in the activities of catalase (CAT), glutathione reductase (GSR), superoxide dismutase (SOD), and glutathione peroxidase (GSH-PX), whereas levels of reactive oxygen species (ROS) and malondialdehyde (MDA) increased. Cd exposure also caused a substantial increase in urea, kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and creatinine levels. Moreover, a noticeable decline was noticed in creatinine clearance. Moreover, Cd exposure considerably increased the levels of inflammatory indices, including interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), nuclear factor kappa-B (NF-kB), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) activity. Cd treatment decreased the expression of the antiapoptotic markers (Bcl-2) while increasing the expression of apoptotic markers (Bax and Caspase-3). Furthermore, Cd treatment substantially reduced the TCA cycle enzyme activity, such as alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and isocitrate dehydrogenase. Moreover, mitochondrial electron transport chain enzymes, succinatedehydrogenase, NADH dehydrogenase, cytochrome c-oxidase, and coenzyme Q-cytochrome reductase activities were also decreased following Cd exposure. PSB administration substantially reduced the mitochondrial membrane potential while inducing significant histological damage. However, PSB treatment significantly reduced Cd-mediated renal damage in rats.ConclusionThus, the present investigation discovered that PSB has ameliorative potential against Cd-induced renal dysfunction in rats.
Applying machine learning techniques to predict the risk of lung metastases from rectal cancer: a real-world retrospective study
Authors: Qiu Binxu , Shen Zixiong , Yang Dongliang , Wang Quan 
Published: May 2023

BackgroundMetastasis in the lungs is common in patients with rectal cancer, and it can have severe consequences on their survival and quality of life. Therefore, it is essential to identify patients who may be at risk of developing lung metastasis from rectal cancer.MethodsIn this study, we utilized eight machine-learning methods to create a model for predicting the risk of lung metastasis in patients with rectal cancer. Our cohort consisted of 27,180 rectal cancer patients selected from the Surveillance, Epidemiology and End Results (SEER) database between 2010 and 2017 for model development. Additionally, we validated our models using 1118 rectal cancer patients from a Chinese hospital to evaluate model performance and generalizability. We assessed our models’ performance using various metrics, including the area under the curve (AUC), the area under the precision-recall curve (AUPR), the Matthews Correlation Coefficient (MCC), decision curve analysis (DCA), and calibration curves. Finally, we applied the best model to develop a web-based calculator for predicting the risk of lung metastasis in patients with rectal cancer.ResultOur study employed tenfold cross-validation to assess the performance of eight machine-learning models for predicting the risk of lung metastasis in patients with rectal cancer. The AUC values ranged from 0.73 to 0.96 in the training set, with the extreme gradient boosting (XGB) model achieving the highest AUC value of 0.96. Moreover, the XGB model obtained the best AUPR and MCC in the training set, reaching 0.98 and 0.88, respectively. We found that the XGB model demonstrated the best predictive power, achieving an AUC of 0.87, an AUPR of 0.60, an accuracy of 0.92, and a sensitivity of 0.93 in the internal test set. Furthermore, the XGB model was evaluated in the external test set and achieved an AUC of 0.91, an AUPR of 0.63, an accuracy of 0.93, a sensitivity of 0.92, and a specificity of 0.93. The XGB model obtained the highest MCC in the internal test set and external validation set, with 0.61 and 0.68, respectively. Based on the DCA and calibration curve analysis, the XGB model had better clinical decision-making ability and predictive power than the other seven models. Lastly, we developed an online web calculator using the XGB model to assist doctors in making informed decisions and to facilitate the model’s wider adoption (https://share.streamlit.io/woshiwz/rectal_cancer/main/lung.py).ConclusionIn this study, we developed an XGB model based on clinicopathological information to predict the risk of lung metastasis in patients with rectal cancer, which may help physicians make clinical decisions.
A phase 1, first-in-child, multicenter study to evaluate the safety and efficacy of the oncolytic herpes virus talimogene laherparepvec in pediatric patients with advanced solid tumors
Authors: Moreno Lucas , Teira Pierre , Croop James M. , Gerber Nicolas U. , André Nicolas , Aerts Isabelle , Gros Subias Luis , De Wilde Bram , Bautista Francisco , Turpin Brian , Kunduri Srinivasa , Hamidi Ali , Lawrence Tatiana , Streby Keri A. 
Published: May 2023

BackgroundThe survival rates for pediatric patients with relapsed and refractory tumors are poor. Successful treatment strategies are currently lacking and there remains an unmet need for novel therapies for these patients. We report here the results of a phase 1 study of talimogene laherparepvec (T-VEC) and explore the safety of this oncolytic immunotherapy for the treatment of pediatric patients with advanced non–central nervous system tumors.MethodsT-VEC was delivered by intralesional injection at 106 plaque-forming units (PFU)/ml on the first day, followed by 108 PFU/ml on the first day of week 4 and every 2 weeks thereafter. The primary objective was to evaluate the safety and tolerability as assessed by the incidence of dose-limiting toxicities (DLTs). Secondary objectives included efficacy indicated by response and survival per modified immune-related response criteria simulating the Response Evaluation Criteria in Solid Tumors (irRC-RECIST).ResultsFifteen patients were enrolled into two cohorts based on age: cohort A1 (n = 13) 12 to ≤21 years old (soft-tissue sarcoma, n = 7; bone sarcoma, n = 3; neuroblastoma, n = 1; nasopharyngeal carcinoma, n = 1; and melanoma, n = 1) and cohort B1 (n = 2) 2 to &lt;12 years old (melanoma, n = 2). Overall, patients received treatment for a median (range) of 5.1 (0.1, 39.4) weeks. No DLTs were observed during the evaluation period. All patients experienced at least one treatment-emergent adverse event (TEAE), and 53.3% of patients reported grade ≥3 TEAEs. Overall, 86.7% of patients reported treatment-related TEAEs. No complete or partial responses were observed, and three patients (20%) overall exhibited stable disease as the best response.ConclusionsT-VEC was tolerable as assessed by the observation of no DLTs. The safety data were consistent with the patients' underlying cancer and the known safety profile of T-VEC from studies in the adult population. No objective responses were observed.Trial RegistrationClinicalTrials.gov: NCT02756845. https://clinicaltrials.gov/ct2/show/NCT02756845.
Understanding feeling “high” and its role in medical cannabis patient outcomes
Authors: Stith Sarah S. , Li Xiaoxue , Brockelman Franco , Keeling Keenan , Hall Branden , Vigil Jacob M. 
Published: May 2023

Introduction: We measure for the first time the associations between subjective patient experiences of feeling “high” and treatment outcomes during real-time Cannabis flower consumption sessions.Methods: Our study uses data from the mobile health app, Releaf App™, through which 1,882 people tracked the effects of Cannabis flower on a multitude of health conditions during 16,480 medical cannabis self-administration sessions recorded between 6/5/2016 and 3/11/2021. Session-level reported information included plant phenotypes, modes of administration, potencies, baseline and post-administration symptom intensity levels, total dose used, and real-time side effect experiences.Results: Patients reported feeling high in 49% of cannabis treatment sessions. Using individual patient-level fixed effects regression models and controlling for plant phenotype, consumption mode, tetrahydrocannabinol (THC) and cannabidiol (CBD) potencies, dose, and starting symptom level, our results show that, as compared to sessions in which individuals did not report feeling high, reporting feeling high was associated with a 7.7% decrease in symptom severity from a mean reduction of −3.82 on a 0 to 10 analog scale (coefficient = −0.295, p &lt; 0.001) with evidence of a 14.4 percentage point increase (p &lt; 0.001) in negative side effect reporting and a 4.4 percentage point (p &lt; 0.01) increase in positive side effect reporting. Tetrahydrocannabinol (THC) levels and dose were the strongest statistical predictors of reporting feeling high, while the use of a vaporizer was the strongest inhibitor of feeling high. In symptom-specific models, the association between feeling high and symptom relief remained for people treating pain (p &lt; 0.001), anxiety (p &lt; 0.001), depression (p &lt; 0.01) and fatigue (p &lt; 0.01), but was insignificant, though still negative, for people treating insomnia. Although gender and pre-app cannabis experience did not appear to affect the relationship between high and symptom relief, the relationship was larger in magnitude and more statistically significant among patients aged 40 or less.Discussion: The study results suggest clinicians and policymakers should be aware that feeling high is associated with improved symptom relief but increased negative side effects, and factors such as mode of consumption, product potency, and dose can be used to adjust treatment outcomes for the individual patient.
An ecological approach to understanding the impact of sexual violence: a systematic meta-review
Authors: Stockman Dagmar , Haney Laura , Uzieblo Kasia , Littleton Heather , Keygnaert Ines , Lemmens Gilbert , Verhofstadt Lesley 
Published: May 2023

AimA systematic meta-review was conducted to examine (1) the broad range of negative and positive individual and interpersonal changes following adult sexual violence, as well as (2) the risk/protective factors at multiple levels of the social ecology (e.g., individual, assault, and micro/meso/exo/macro/chronosystem factors)—influencing the impact of sexual violence.MethodsSearches of Web of Science, Pubmed, and ProQuest resulted in inclusion of 46 systematic reviews or meta-analyses. Review findings were extracted for summary and a deductive thematic analysis was conducted.ResultsExperiencing sexual violence is associated with many negative individual and sexual difficulties as well as revictimization risk. Only a limited number of reviews reported on interpersonal and positive changes. Factors at multiple levels of the social ecology play a role in the intensity of these changes. Reviews including macrolevel factors were non-existent, however.ConclusionReviews on sexual violence are fragmented in nature. Although the use of an ecological approach is often lacking, adopting such a perspective in research is necessary for a fuller understanding of the multiple influences on survivor outcomes. Future research should evaluate the occurrence of social and positive changes following sexual violence, as well as the role of macrolevel factors in influencing post-assault outcomes.
The effectiveness of an additive informal social network intervention for forensic psychiatric outpatients: results of a randomized controlled trial
Authors: Swinkels Lise T. A. , van der Pol Thimo M. , Twisk Jos , ter Harmsel Janna F. , Dekker Jack J. M. , Popma Arne 
Published: May 2023

ObjectivesA supportive social network is associated with better mental health and wellbeing, and less criminal behavior. Therefore, this study examined the effectiveness of an additive informal social network intervention to treatment as usual (TAU) among forensic psychiatric outpatients.Materials and methodsAn randomized controlled trial (RCT) was conducted in forensic psychiatric care, allocating eligible outpatients (N = 102) to TAU with an additive informal social network intervention or TAU alone. Participants receiving the additive intervention were matched to a trained community volunteer over 12 months. TAU consisted of forensic care (e.g., cognitive behavioral therapy and/or forensic flexible assertive community treatment). Follow-up assessments were conducted at 3, 6, 9, 12, and 18 months after baseline. The primary outcome was the between-group effect on mental wellbeing at 12 months. Between-group effects on secondary outcomes (e.g., general psychiatric functioning, hospitalization, criminal behavior) were explored.ResultsIntention-to-treat analyses showed non-significant between-group effects on mental wellbeing on average over time and at 12 months. However, significant between-group effects were found on hospitalization duration and criminal behavior. Specifically, TAU participants were hospitalized 2.1 times more days within 12 months and 4.1 more days within 18 months than participants in the additive intervention. Furthermore, TAU participants reported 2.9 times more criminal behaviors on average over time. There were no significant effects on other outcomes. Exploratory analyses revealed that sex, comorbidity, and substance use disorders moderated effects.ConclusionThis is the first RCT examining the effectiveness of an additive informal social network intervention in forensic psychiatric outpatients. Although no improvements were found on mental wellbeing, the additive intervention was effective in reducing hospitalization and criminal behavior. The findings suggest that forensic outpatient treatment can be optimized by collaborating with informal care initiatives aimed at improving social networks within the community. Future research is warranted to determine which specific patients might benefit from the intervention and if effects can be improved by extending the intervention duration and enhancing patient compliance.Clinical Trial Registration: [https://trialsearch.who.int/Trial2.aspx?TrialID=NTR7163], identifier [NTR7163].
Wellbeing measures for workers: a systematic review and methodological quality appraisal
Authors: Jarden Rebecca J. , Siegert Richard J. , Koziol-McLain Jane , Bujalka Helena , Sandham Margaret H. 
Published: May 2023

IntroductionIncreasing attention on workplace wellbeing and growth in workplace wellbeing interventions has highlighted the need to measure workers' wellbeing. This systematic review sought to identify the most valid and reliable published measure/s of wellbeing for workers developed between 2010 to 2020.MethodsElectronic databases Health and Psychosocial Instruments, APA PsycInfo, and Scopus were searched. Key search terms included variations of [wellbeing OR “well-being”] AND [employee*OR worker*OR staff OR personnel]. Studies and properties of wellbeing measures were then appraised using Consensus-based Standards for the selection of health Measurement Instruments.ResultsEighteen articles reported development of new wellbeing instruments and eleven undertook a psychometric validation of an existing wellbeing instrument in a specific country, language, or context. Generation and pilot testing of items for the 18 newly developed instruments were largely rated 'Inadequate'; only two were rated as 'Very Good'. None of the studies reported measurement properties of responsiveness, criterion validity, or content validity. The three instruments with the greatest number of positively rated measurement properties were the Personal Growth and Development Scale, The University of Tokyo Occupational Mental Health well-being 24 scale, and the Employee Well-being scale. However, none of these newly developed worker wellbeing instruments met the criteria for adequate instrument design.DiscussionThis review provides researchers and clinicians a synthesis of information to help inform appropriate instrument selection in measurement of workers' wellbeing.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=79044, identifier: PROSPERO, CRD42018079044.
Analisis Potensi dan Prioritas Pengembangan Ekowisata Lembah Baliem Selama Masa Pandemi Covid-19
Authors: Siska Defran , Sumaryadi Agus , Gunawan Nanang 
Published: May 2023

Lembah Baliem memiliki berbagai macam situs wisata yang berpotensi untuk dikembangkan. Nilai jual dari mayoritas objek wisata di Lembah Baliem bertumpu pada keunikan dan kelestarian baik kondisi alam maupun budaya masyarakat setempat. Upaya pengembangan tersebut semestinya juga harus memperhatikan aspirasi-aspirasi masyarakat lokal seperti yang berhubungan dengak hak ulayat, penghormatan terhadap situs-situs yang dianggap keramat dan adat istiadat setempat. Hal tersebut menuntut arah pengembangan produk wisata berbasis lingkungan atau ecotourism. Di samping itu, pandemi covid-19 tidak hanya berdampak negatif bagi industri pariwisata tetapi juga memberikan kesempatan positif bagi restorasi lingkungan sekaligus menjadi variabel penting dalam pengembangan untuk menghadapi era new normal. Oleh karena itu penelitian ini bertujuan untuk menganalisis potensi pengembangan situs wisata yang ada di Lembah Baliem dengan kerangka kerja Ecotourism Opportunity Spectrum. Selain itu, lokasi yang telah teridentifikasi perlu ditentukan prioritas pengembangannya sesuai dengan kriteria ecotourism menggunakan metode analytical hierarchy process agar dapat menjadi rekomendasi kepada stake holder di Lembah Baliem. Sebanyak 8 situs wisata telah teridentifikasi dan telah ditetapkan urutan prioritas pengembangannya antara lain: (1) Festival Budaya Lembah Baliem dengan skor prioritas sebesar 0,255. (2) Pasir Putih (Intermediates) (0,131), (3) Mumi Yiwika (0,125), (4) Mumi Aikima (Ecogeneralist) (0,119), (5) Goa Bunda Maria (Intermediates)(0,099), (6) Danau Habema (Ecospecialist) (0,093), (7) Air Terjun Napua (0,091), dan (8) Telaga Biru (Ecogeneralist) (0,088).
اثر خرائط المفاهيم في التحصيل والتفكير الرياضي
Authors: أ.م. د. صادق مطشر عليخ  
Published: May 2023

هدف البحث الحالي الى التعرف على اثر خرائط المفاهيم في التحصيل والتفكير الرياضي، وتم اختيار تصميم جزئي ذي مجموعتين (التجربة والضابطة) حيث تكوين عينة البحث (60) طالب من طلبة المرحلة الاولى كلية التربية الاساسية ولتأكد تكافؤ طلبة المجموعتين في المتغيرات ( العمر الزمني _ التحصيل السابق _ الذكاء ) حيث اعد الباحثان اختبارين احدهما تحصيلي والاخر للتفكير الرياضي لمجالاته الستة ( الاستقراء – الاستنتاج - التعبير بالرموز – والتفكير العقلاني والتفكير المنظم – حل المشكلات ) تألف الاختبار التحصيلي من (30) فقرة من نوع الاختبار من متعدد والتأكد من الصدق الظاهري وصدق المحتوى وثم حساب معامل الصعوبة لكل فقرة حيث تراوحت (0.46 – 0.68 ) ومعاملات التمييز تراوحت (0.24- 0.52) وتم حساب معامل الثبات باستعمال معادلة KR-20 فكان معامل الثبات ( 0.84) اما الاختبار التفكير الرياضي تالف من (30) فقرة من نوع الاختبار المتعدد وتم التأكد من صدقه الظاهري وحساب معامل الصعوبة وجد انها تتراوح (0.20- 0.80 ) امل معامل الثبات فتم حسابه باستعمال معادلة KR-20 فكان (0.85) واظهرت النتائج وجود فرق ذي دلالة احصائية عند مستوى (0.05) من بين متوسطي درجات المجموعة التجريبية التي درست مادة الاحصاء باستخدام خرائط المفاهيم والمجموعة الثانية التي درست على وفق ( الطريقة الاعتيادية) في الاختبار التحصيلي واختبار التفكير الرياضي ولصالح المجموعة للتجريبية
اثر استراتيجية التعلم التعاوني وفقا لاستراتيجية التعلم معا والمجموعات المتداخلة في تعلم بعض المهارات بكرة القدم الصالات
Authors: هبة خلفة علي  , ا.د اسماعيل عبد زيد عاشور  
Published: May 2023

هدف البحث إعداد وحدات تعليمية على وفق التعلم معا والمجموعات المتداخلة في تعلم بعض المهارات بكرة القدم للصالات ومعرفة تأثير التعلم معا والمجموعات المتداخلة في تعلّم بعض المهارات بكرة القدم للصالات والتعرف على أي النمطين الأفضل في تعلم بعض المهارات بكرة القدم للصالات. استعمل الباحثان المنهج التجريبي الملائم في حل مشكلة البحث وتحقيق الأهداف، حيث إن المنهج التجريبي تم اختيار مجتمع البحث بالطريقة العمدية وذلك لقرب المدرسة من سكن الباحثان ووجود ادارة متعاونة مع الباحثان ولوجود مدرس كفؤ في المدرسة التي تمثل طلاب الصف الثاني للمرحلة المتوسطة من متوسطة الفتوة للبنين إحدى مدارس مديرية تربية بغداد الرصافة/3 للعام الدراسي (2021–2022) والبالغ عددهم (105) طالباً. أما اختيار عينة البحث فهي مهمة جدا ويجب الاهتمام بها لان العينة يجب أن تمثل مجتمع البحث تمثيلا حقيقيا وصادقا لآجل الحصول على نتائج أكثر شمولية لذلك فتم اختيار العينة بالطريقة العشوائية, وبعد ما قامت الباحثان بتحديد المجتمع وكان عددهم(105) طالباً, تم استبعاد (24) من الطلاب الراسبين والممارسين للعبة في الأندية الرياضية, والطلبة الذين يتعذر عليهم المشاركة بسبب سوء حالتهم الصحية ولديهم تقارير طبية تثبت ذلك, وتم اختيار (21) من الطلاب للتجربة الاستطلاعية , وعينة البحث تم اختيارها بطريقة القرعة وبهذا تكونت العينة من(60) طالباً ,(20) طالباً يمثلون شعبة (أ) الذين استخدمت معهم استراتيجية التعلم التعاوني وفق التعلم معا, و(20) طالباً يمثلون شعبة (ب)الذين استخدمت معهم التعلم التعاوني وفق المجموعات المتداخلة, و(20) طالباً يمثلون شعبة (ج) الذين استخدمت كمجموعة ضابطة تمارس على وفق الاستراتيجية المتبع من قبل المدرس في المدرسة وقد بلغت نسبة العينة لمجتمع البحث (57%).ومن اهم الاستنتاجات تحسن أداء بعض المهارات الأساسية بكرة القدم للصالات لأفراد المجموعة التي خضعت للمنهج التعليمي على وفق التعلم معا. تحسن أداء بعض المهارات الأساسية بكرة القدم للصالات لأفراد المجموعة التي خضعت للمنهج ألتعلمي وفق المجموعات المتداخلة ومن اهم التوصيات ضرورة استعمال استراتيجية التعلم التعاوني على وفق (التعلم معا والمجموعات المتداخلة ) في تطوير المهارات بكرة القدم للصالات و ضرورة تأكيد استعمال هذه النمطين عند تعلم هذه الفئة العمرية بالذات، لكونه يعزز روح الحماس والعمل الجماعي بين إفراد الفريق
التشوهات المعرفية لدى معلمات رياض الاطفال الحكومية والاهلية
Authors: أ.م. اسيل اسماعيل محمد  
Published: May 2023

يستهدف البحث الحالي التعرف على التشوهات المعرفية لدى معلمات رياض الاطفال الحكومية والاهلية ,و يقتصر البحث الحالي على معلمات رياض الاطفال في محافظة بغداد/ الرصافة الثالثة للعام الدراسي 2018/2019. اختارت الباحثة عينة بحثها من معلمات رياض الاطفال الحكومية التابعة لمديرية تربية/ الرصافة الثالثة البالغة عددهن (50) معلمة بالطريقة العشوائية البسيطة بواقع البالغ عددهن (30 ) معلمة من الروضات الحكومية في (3) روضات و (20) معلمة من الروضات الاهليه في (3) روضات اهلية. تبنت الباحثة مقياس (ثويني 2018 ) يتألف هذا المقياس من (50 فقرة) وامام كل فقرة ثلاث بدائل للاجابة هي (دائماً ، غالباً ، احياناً ) بحيث اعطيت درجة 3 للبديل دائماُ واعطيت درجة 2 للبديل غالباً واعطيت درجة 1 للبديل احياناً وبذلك تكون اعلى درجة تحصل عليها المعلمة على المقياس (150) درجة واقل درجة (50) وبذلك يصبح المتوسط الفرضي للمقياس (75). ولتحقق من الصدق الظاهري عرضت الباحثة اداة بحثها على مجموعة من الخبراء والمتخصصين في مجال العلوم التربوية والنفسية وقد اعتمدت الباحثة لحساب ثبات المقياس الحالي وهي طريقة الفاكر وبناخ بلغ معامل الثبات المحسوب بهذه الطريقة (0.81) وهو معامل ثبات جيد ،وتوصلت الباحثة الى ان معلمات رياض الاطفال الحكومية والاهلية لا يتصف بالتشوهات المعرفية