bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed elimination communication is a crucial factor in disposable diaper dependence in Chinese preschool-aged children
Authors: Yu Jia-ting , Mao Qiu-fang , Ji Feng-ping , Zhao Ying , Hu Hui-jie , Zhang Yan-ping , Yang Jing , Wang Qing-wei , Lu Wei , Wen Jian Guo 
Published: January 2023

PurposeElimination communication (EC) is considered to be a milestone in a child's development. Nowadays, a trend toward an older age at EC initiation has been observed globally, probably due to the convenience of disposable diaper use in daily life. The study aimed to identify potential risk factors for disposable diaper dependence (DDD) and evaluate whether an early/proper EC can reduce the risk of DDD among children in China.MethodsA cross-sectional study was performed on 13,500 children in mainland China from October 2019 to March 2020. An anonymous questionnaire was used to collect information including the sociodemographic characteristics, details about DDD and EC, and the effect of DDD on the quality of life of children. Data were analyzed by SPSS and R software.ResultsThe overall prevalence of DDD was 4.17% (4.31% in boys; 4.02% in girls) and decreased with age, from 8.71% at 2 years to 0.73% at 6 years (χ2trend = 210.392, P &lt; 0.001). In univariable analysis, age, location or EC were associated with DDD. Four independent factors—age, location (urban), caregivers with high education levels (junior college or above) and delayed EC (after 12 months of age)—were identified to be significantly associated with DDD risk in logistic regression model. Compared with EC onset after 12 months of age, EC onset before 12 months of age was associated with a 79.6% (model 2) reduction in DDD. Four independent factors were selected to establish the nomogram for DDD based on the results of logistic regression analysis. The C-index (0.770) and the AUC (&gt;0.7) indicated satisfactory discriminative ability of the nomogram. The calibration diagrams showed favorable consistency between the prediction of the nomogram and actual observations.ConclusionOur findings indicate the joint contribution of age, location, caregivers’ education level and EC to DDD in Chinese preschool-aged children. Timely cessation of the use of disposable diapers and early/proper EC may help to reduce the risk of DDD in children.
Management and effects of residual limbus inversion following closed reduction in developmental hip dysplasia: Protocol for a multicenter randomized controlled trial
Authors: Li Chenyang , Zhou Weizheng , Chen Yufan , Canavese Federico , Li Lianyong 
Published: January 2023

Closed reduction is a common treatment method for developmental dysplasia of the hip (DDH) in children aged 6–18 months. Residual acetabular dysplasia (RAD) is the most common complication associated with closed reduction. Residual limbus inversion (RLI) is a common condition following DDH closed reduction. Previously, we confirmed that when limbus inversion exceeds 32.2% of the acetabular depth after closed reduction, RLI persists and leads to RAD; however, this was based on a small cohort with a short-term follow-up period. The long-term fate of RLI and the correlation between RLI and RAD have yet to be verified. Therefore, this multicenter clinical study protocol was designed in three parts to investigate the effect of RLI on acetabular development after closed reduction of DDH (a multicenter retrospective cohort study), effect of RLI clearance on acetabular development (a multicenter retrospective and prospective randomized controlled study), and influence of inverted limbus clearance on acetabular development during DDH reduction (a multicenter prospective cohort study). Statistical analysis was performed by assessing the basic measures of acetabular development including the acetabular index and central-edge angle using frontal pelvic radiographs; the magnitude of limbus inversion, cartilaginous acetabular index, and T1ρ mapping values were measured using magnetic resonance imaging. The multicenter retrospective cohort studies required 5 years of follow-up period at minimum, and the prospective randomized controlled studies required reviews of frontal pelvic radiographs every 6 months as well as data pooling every 2 years to compare the short- and mid-term outcomes of hip joint morphological development between the two groups of pediatric patients. This research program is expected to verify that RLI following closed reduction of DDH can affect acetabular development and that limbus excision during DDH reduction can improve postoperative RAD. Therefore, the indication and timing of surgical intervention for RLI after closed reduction of DDH provide a basis for revising the acceptable criteria for utilizing closed reduction of DDH to reduce the incidence of osteoarthritis caused by RAD following DDH treatment.Clinical Trial:http://www.chictr.org.cn/showproj.aspx?proj=35045 (ChiCTR1900020996)
Single-incision laparoscopic splenectomy in children with massive splenomegaly: A prospective, monocentric pilot study
Authors: Wang Congjun , Su Cheng , Chen Chao , Tang Xianming , Wang Hong , Li Wei , Li Yanqiang , Liu Qiang , Chen Peng , Li Yong , Luo Yige 
Published: January 2023

BackgroundSingle-incision laparoscopic splenectomy (SILS) remains a challenging procedure because of the technical difficulty. In this prospective study, we aimed to evaluate the efficacy and safety of SILS in children with massive splenomegaly.MethodsPediatric patients with massive splenomegaly were recruited for SILS in a university-affiliated hospital. The data on patient demographics, clinical features, operative variables, and perioperative outcomes were collected prospectively and analyzed. According to the different surgical instruments, the patients were randomly assigned into two groups: the SILS with straight surgical instrument (SILS-S) group and the SILS with curved surgical instrument (SILS-C) group. A two-group comparative analysis was conducted using perioperative data from the different surgical instrumentation systems.ResultsA total of 120 patients were included, of which 103 patients (success group, 85.83%) had complete SILS, the other 17 (failure group, 14.17%) patients were converted to open (n = 4, 3.33%) or multi-incision laparoscopic surgery (n = 13, 10.83%). The major cause for surgical failure is uncontrollable bleeding (n = 14, 82.35%), and age, height, and weight were the risk factors for failure of SILS, but none of the parameters were independent risk factors. The blood loss in the success group was less than that in the failure group, but no significant differences in other operative and outcome indicators. For SILS, the mean (±SD) operative time was 188 (±48.70) minutes, the median intraoperative blood loss (min, max) was 20 (5, 290) ml, the mean (±SD) time of first anal exhaust was 23.9 (±7.73) hours, and the mean (±SD) postoperative hospital stay was 4.72 (±1.03) days. The median pain score was 3 on 1 day, and 1 on 3 days after the operation. Postoperative complications were identified in 8 (7.77%) cases. However, there were no peri-operative deaths in this series. The SILS-C group had a significantly shorter operation time than the SILS-S group (mean ± SD, 172 ± 44.21 vs. 205 ± 47.90 min). There were no significant differences between the two groups in other perioperative data (P &lt; 0.05).ConclusionSILS is a safe and feasible treatment in pediatric patients with massive splenomegaly, and curved surgical instrumentation has contributed to developing surgical manipulation.
Effect of massage therapy on infants with congenital muscular torticollis: A retrospective comparative study
Authors: Tang Wei , Li Zhoujin , Xu Weihui , Ye Yong , Wang Huijuan , Wang Ying , Shao Xiangning , Wang Mengqing , Xu Jianda 
Published: January 2023

ObjectiveTo detect the effect and safety of massage therapy on infants with congenital muscular torticollis.MethodsA total of 56 infants with unilateral congenital muscular torticollis were enrolled in this retrospective comparative study. The subjects were divided in two groups, namely, the control group and the massage group. The control group (n = 28) received the treatment of sternocleidomastoid muscle (SCM) stretching, while the massage group (n = 28) received massage therapy combined with SCM stretching. The following parameters were compared: the cervical range of motion (ROM) and functional level (muscle function scale and ratio of muscle function scale scores). Complications, if any, were also recorded.ResultsOf the 56 infants, 7 infants (12.5%) underwent surgery with little functional improvement. The total effective rate of conservative treatment was 87.5%. No significance was found in terms of the surgery rate between both groups (14.29 vs. 10.71%, P = 0.693). After treatment, the ROM (including rotation and lateral flexion) and the ratio of muscle function scale scores improved significantly (P &lt; 0.05). In the latest follow-up, the massage group showed a greater improvement in rotation and lateral flexion. However, no significant difference in the muscle function scale score ratio was found (P = 0.126). Importantly, no adverse events related to blood vessels, nerves, and SCM occurred.ConclusionsProviding massage therapy in infants with congenital muscular torticollis is a safe and effective method to improve the cervical range of motion and function. However, this study did not find any decrease in the surgical rate between two groups of patients despite adding such therapy.
Anti-inflammatory activities of Coleus forsteri (formerly Plectranthus forsteri) extracts on human macrophages and chemical characterization
Authors: Nicolas Mael , Lasalo Malia , Chow Sharron , Antheaume Cyril , Huet Karl , Hnawia Edouard , Guillemin Gilles J. , Nour Mohammed , Matsui Mariko 
Published: January 2023

Introduction: Formerly named Plectranthusforsteri, Coleus forsteri (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant.Method: Herein, we investigated anti-inflammatory potential of C. forsteri ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers.Results: Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished under ePE and cPE treatment in activated human monocyte-derived macrophages (MDMs). Seven abietane diterpenes were characterized from C. forsteri cPE including coleon U (1), coleon U-quinone (2), 8α,9α-epoxycoleon U-quinone (3), horminone or 7α-hydroxyroyleanone (4), 6β,7α-dihydroxyroyleanone (5), 7α-acetoxy-6β-hydroxyroyleanone (6) and 7α-formyloxy-6β-hydroxyroyleanone (7).Discussion: We discussed potential contributions of these molecules from C. forsteri extracts for their anti-inflammatory activities.
Immediate effects of forefoot wedges on multi-segment foot kinematics during jogging in recreational runners with a symptomatic pronated foot
Authors: Zhang Xianyi , Vanwanseele Benedicte 
Published: January 2023

Background: Foot orthoses (FOs) have been used to alter lower limb kinematics and kinetics in pronated feet. A clear relationship between FOs’ features, e.g., the amount of wedging and support, and the corresponding biomechanical responses is vital for the design and prescription of FOs. In this study, we sought to determine if changing the level of the forefoot wedge would cause a linear response in the multi-segment foot kinematics during jogging, and if this effect would be enhanced by an arch support.Methods: Ten pairs of 3D printed FOs with five levels of forefoot wedges and two levels of arch supports were tested on 12 recreational runners with a symptomatic pronated foot. Multi-segment foot kinematic data during jogging was measured using the Oxford Foot Model. Two-way ANOVAs were performed to examine the main effect of the forefoot wedge and arch support, as well as their interaction on peak joint angles. Statistical parametric mapping and paired-t tests were used to identify differences in the foot kinematic traces and the joint range of motion (ROM) between each FO and the control, respectively.Results: Linear main effects for the forefoot wedge level were found in the forefoot peak dorsiflexion, eversion and rearfoot peak dorsiflexion of jogging. FOs with a medial forefoot wedge caused an average of 2.5° reduction of the forefoot peak abduction during jogging. Furthermore, forefoot wedges showed an opposite effect on the sagittal ROM of the forefoot and rearfoot. Adding an arch support did not improve the kinematic performance of a forefoot wedge during jogging.Conclusion: This study highlights a linear dose-response effect of a forefoot wedge on forefoot kinematics during jogging, and suggests using a medial forefoot wedge as an anti-pronator component for controlling forefoot motion of a pronated foot.
The significant clinical correlation of the intratumor oral microbiome in oral squamous cell carcinoma based on tissue-derived sequencing
Authors: Li Zhengrui , Fu Rao , Wen Xutao , Wang Qi , Huang Xufeng , Zhang Ling 
Published: January 2023

Background: The microbiota is a critical component of the complex human microenvironment, impacting various physiological processes and disease development via the microbe–host interaction. In particular, the oral microbiota profoundly affects tumor development and progression. There is increasing evidence that oral microbiota is associated with the development of oral cancer, especially oral squamous cell carcinoma (OSCC).Methods: We comprehensively analyzed the oral microbiota in 133 OSCC samples worldwide. Subsequently, we evaluated the microbial compositions between OSCC patients and healthy people and their correlation with clinical parameters. The value of the oral microbiota as a diagnostic and prognostic biomarker was also determined.Results: This study found differences in critical oral microbiota between OSCC and normal controls. The most notable differences are present in p_Firmicutes, p_Actinobacteria, c_Fusobacteriia, o_Fusobacteriales, f_Fusobacteriaceae, and g_Fusobacterium. All six-level oral microorganisms were also associated with the clinical characteristics of OSCC, particularly with the clinical outcomes (survival time and status). We developed a predictive model based on this. We found that five different oral microorganisms have high confidence and can be used for clinical diagnosis and prognostic prediction, except for p_Actinobacteria.Conclusion: This study revealed that the intratumor oral microbiota of OSCC patients worldwide and the microbial signatures of OSCC patients possess similar properties in different regions, further refining the shortcomings of the current research field. We revealed that the oral microbiota could be used as a biomarker to reflect human health and disease progression status. This will provide new directions for tumor microbiome research. This means we can develop strategies through diet, probiotics, and antibiotics for cancer prevention and treatment.
Analysis of the motivational processes involved in university physical activity
Authors: Durán-Vinagre Miguel Ángel , Ibáñez Sergio J. , Feu Sebastián , Sánchez-Herrera Susana 
Published: January 2023

IntroductionPhysical activity plays an important role in all stages of development, especially in adolescence, as it is a period in which different lifestyles are shaped. Therefore, regular practice of physical activity contributes to an improvement in quality of life. This study analyzed university students’ motivational processes and intention to be physically active when engaging in physical activity (PA) according to gender and fields of study.MethodsA total of 1.524 subjects participated in the study, 61.9% (n = 944) of whom were female and 38.1% (n = 580) were male, with an average age of 19.61 years. The fields of study consisted of Arts and Humanities (n = 118), Science (n = 132), Health Sciences (n = 351), Engineering and Architecture (n = 196) and Social and Legal Sciences (n = 727). The instruments used were the Behavioral Regulation in Exercise Questionnaire (BREQ-3) and the Intention to be Physically Active in the University Context (MIFAU) measurement scale.ResultsThe results showed statistically significant differences in favour of men (p &lt;0.01) in terms of intrinsic, integrated, identified, and introjected regulation of PA. Similarly, men were more likely to be physically active in the future than women (p &lt;0.001). In terms of the study variables relating to the fields of study, statistically significant differences were obtained in the case of both more self-determined behavior (intrinsic, integrated and identified regulation) and amotivation (p &lt;0.001).ConclusionIt was concluded that there is a need for the promotion of intervention strategies to encourage young adults to take up sporting activities as a means of preventing noncommunicable diseases, thereby avoiding the negative consequences of a sedentary lifestyle, physical inactivity, or abandonment of such activities.
How relationship-maintenance strategies influence athlete burnout: Mediating roles of coach–athlete relationship and basic psychological needs satisfaction
Authors: Fan Fenghui , Chen Jinyu , Chen Yunting , Li Bing , Guo Liya , Shi Yang , Yang Feng , Yang Qinjun , Yang Longfei , Ding Cody , Shi Huiying 
Published: January 2023

IntroductionAthlete burnout has many potential negative effects on athletes’ sporting performance and careers. Maintaining and promoting the coach–athlete relationship to meet athletes’ basic psychological needs is one way to reduce burnout. Existing studies of the correlation between coach-athlete relationships and athlete burnout have mainly focused on the coaches’ leadership style, with little attention given to relationship-maintenance strategies and the mechanism of athlete burnout from the athletes’ perspective.MethodsUsing an online survey of 256 adolescent athletes, we explore the relationship between relationship-maintenance strategies and athlete burnout, including the potential mediating effects of the coach–athlete relationship and basic psychological needs satisfaction.Results(1) Athletes’ relationship-maintenance strategies negatively predicted athlete burnout. (2) Besides the direct effect, we found evidence to support three mediation paths: (a) the coach–athlete relationship, (b) basic psychological needs satisfaction, and (c) both as serial mediators.DiscussionThese findings enhance understanding of the mechanism of athlete burnout, demonstrating the influence of factors beyond the coach’s role. The study also provides a theoretical basis for practical intervention by coaches, athletes, and sports organizations to reduce athlete burnout by focusing on athletes’ perspectives.
How you get it matters: Moderating role of transfer method in guiding ownership assignments for modified objects
Authors: Li Zhanxing , Dong Dong 
Published: January 2023

IntroductionPrevious research has found that value change and creation drive people to support the laborer more than the original owner in ownership reasoning for modified objects; however, the transfer methods used to resolve conflicts have largely been ignored. In this work, two studies were designed to investigate the role of value change and creation in adults’ labor-based ownership judgments in four transfer conditions (i.e., take/steal/borrow/find).MethodsScenarios involving different extent of value change and creation in different transfer ways were presented to Chinese adult subjects after which they were asked to judge who is the owner.ResultsPeople were more likely to assign ownership to the original owner in the take, steal and borrow conditions but not in the find condition, and this reasoning held regardless of whether the original materials showed high or low value appreciation or successful creation, and it was applicable to raw materials with low (Study 1) and high values (Study 2). In addition, the effect of value change and creation on ownership reasoning varied according to different transfer methods.ConclusionThe results suggest the moderating role of transfer method in people’s ownership assignments, which will provide insights for real-life mediation of ownership conflicts.
Human threat circuits: Threats of pain, aggressive conspecific, and predator elicit distinct BOLD activations in the amygdala and hypothalamus
Authors: Bertram Teresa , Hoffmann Ayala Daniel , Huber Maria , Brandl Felix , Starke Georg , Sorg Christian , Mulej Bratec Satja 
Published: January 2023

IntroductionThreat processing, enabled by threat circuits, is supported by a remarkably conserved neural architecture across mammals. Threatening stimuli relevant for most species include the threat of being attacked by a predator or an aggressive conspecific and the threat of pain. Extensive studies in rodents have associated the threats of pain, predator attack and aggressive conspecific attack with distinct neural circuits in subregions of the amygdala, the hypothalamus and the periaqueductal gray. Bearing in mind the considerable conservation of both the anatomy of these regions and defensive behaviors across mammalian species, we hypothesized that distinct brain activity corresponding to the threats of pain, predator attack and aggressive conspecific attack would also exist in human subcortical brain regions.MethodsForty healthy female subjects underwent fMRI scanning during aversive classical conditioning. In close analogy to rodent studies, threat stimuli consisted of painful electric shocks, a short video clip of an attacking bear and a short video clip of an attacking man. Threat processing was conceptualized as the expectation of the aversive stimulus during the presentation of the conditioned stimulus.ResultsOur results demonstrate differential brain activations in the left and right amygdala as well as in the left hypothalamus for the threats of pain, predator attack and aggressive conspecific attack, for the first time showing distinct threat-related brain activity within the human subcortical brain. Specifically, the threat of pain showed an increase of activity in the left and right amygdala and the left hypothalamus compared to the threat of conspecific attack (pain &gt; conspecific), and increased activity in the left amygdala compared to the threat of predator attack (pain &gt; predator). Threat of conspecific attack revealed heightened activity in the right amygdala, both in comparison to threat of pain (conspecific &gt; pain) and threat of predator attack (conspecific &gt; predator). Finally, for the condition threat of predator attack we found increased activity in the bilateral amygdala and the hypothalamus when compared to threat of conspecific attack (predator &gt; conspecific). No significant clusters were found for the contrast predator attack &gt; pain.ConclusionResults suggest that threat type-specific circuits identified in rodents might be conserved in the human brain.