bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Electronic Health Record-Based Machine Learning Models to Predict Barrett's Esophagus and Esophageal Adenocarcinoma Risk
Authors: Iyer Prasad G. , Sachdeva Karan , Leggett Cadman L. , Codipilly D. Chamil , Abbas Halim , Anderson Kevin , Kisiel John B. , Asfahan Shahir , Awasthi Samir , Anand Praveen , Kumar M Praveen , Singh Shiv Pratap , Shukla Sharad , Bade Sairam , Mahto Chandan , Singh Navjeet , Yadav Saurav , Padhye Chinmay 
Published: September 2023

INTRODUCTION:
Screening for Barrett's esophagus (BE) is suggested in those with risk factors, but remains underutilized. BE/esophageal adenocarcinoma (EAC) risk prediction tools integrating multiple risk factors have been described. However, accuracy remains modest (area under the receiver-operating curve [AUROC] ≤0.7), and clinical implementation has been challenging. We aimed to develop machine learning (ML) BE/EAC risk prediction models from an electronic health record (EHR) database.

METHODS:
The Clinical Data Analytics Platform, a deidentified EHR database of 6 million Mayo Clinic patients, was used to predict BE and EAC risk. BE and EAC cases and controls were identified using International Classification of Diseases codes and augmented curation (natural language processing) techniques applied to clinical, endoscopy, laboratory, and pathology notes. Cases were propensity score matched to 5 independent randomly selected control groups. An ensemble transformer-based ML model architecture was used to develop predictive models.

RESULTS:
We identified 8,476 BE cases, 1,539 EAC cases, and 252,276 controls. The BE ML transformer model had an overall sensitivity, specificity, and AUROC of 76%, 76%, and 0.84, respectively. The EAC ML transformer model had an overall sensitivity, specificity, and AUROC of 84%, 70%, and 0.84, respectively. Predictors of BE and EAC included conventional risk factors and additional novel factors, such as coronary artery disease, serum triglycerides, and electrolytes.

DISCUSSION:
ML models developed on an EHR database can predict incident BE and EAC risk with improved accuracy compared with conventional risk factor-based risk scores. Such a model may enable effective implementation of a minimally invasive screening technology.
Die epistemische Verflechtung von Kanonkritik und kanonischen Repräsentationspraktiken
Authors: Steins Antonia 
Published: September 2023

Abstract
The critical reception of racist, sexist and anti-Jewish dimensions in the works of canonical authors has moved to the center of philosophical discourse. Many of those who engage in the history of philosophy have defended the established canon and advocated for critical readings. I want to show that the current discourse on Hegel’s treatment of religion misreads his position as “modern”, because it does not take the works of his Jewish contemporaries into account. In my own reading of the Grundlinien, I will show that Hegel’s concept of the division of Church and state does not remain neutral when it comes to religious affiliation but has a clear anti-Jewish bias (I). This serves to show that one can neither adequately identify nor address identity-based discrimination in the works of majoritarian thinkers without an equal commitment to diversifying the canon to include positions of marginalised authorship (II).
Design parameters and mechanical efficiency of jet wind turbine under high wind speed conditions
Authors: Dahham Abbas Waheed , Kasenov Asylbek Zhumabekovich , Aljibory Mohammed Wahhab , Hilal Mahmood Mohammed , Abishev Kairatolla Kayrollinovich , Kereyovna Mussina Zhanara , Sembayev Nurbolat Sakenovich , Dahham Hussein Waheed , Bykov Petr Olegovich , Alirakhimovich Adamov Abilmazhin 
Published: September 2023

Abstract
Turbines are one of the most important means of producing clean energy, as they do not cause any negative emissions affecting the environment. Recently, the need to design turbines capable of facing strong winds has appeared because the currently designed turbines must be cut off in such circumstances. This study aims to find the best design parameters and investigate the efficiency of the jet turbine at high wind speed conditions. SolidWorks and MatLab are used to design and analyze small jet wind turbines. The design parameters were chosen to obtain the best efficiency. The turbine diameter is 0.5 m, and the short blade length helps withstand the generated stresses due to strong wind, especially fatigue stress, and resists bending. Blade pitch angle beta starts from 2° from the vertical axis at the hub and changes harmonically along the length to end at an angle of 88° at the blade’s tip to allow air to pass through and not form a wall. The blade number has chosen 15 blades, corresponding to the Betz limit, to obtain the maximum power coefficient. As a result, the assigned power was obtained at a wind speed of 28 m/s. At a lower wind speed, it will work with acceptable efficiency and more efficiently at higher speeds. Therefore, this turbine is suitable to use in such cases.
The promise of genetic screens in human in vitro brain models
Authors: Beirute-Herrera Julianne , López-Amo Calvo Beatriz , Edenhofer Frank , Esk Christopher 
Published: September 2023

Abstract
Advances of in vitro culture models have allowed unprecedented insights into human neurobiology. At the same time genetic screening has matured into a robust and accessible experimental strategy allowing for the simultaneous study of many genes in parallel. The combination of both technologies is a newly emerging tool for neuroscientists, opening the door to identifying causal cell- and tissue-specific developmental and disease mechanisms. However, with complex experimental genetic screening set-ups new challenges in data interpretation and experimental scope arise that require a deep understanding of the benefits and challenges of individual approaches. In this review, we summarize the literature that applies genetic screening to in vitro brain models, compare experimental strengths and weaknesses and point towards future directions of these promising approaches.
Efficient employment of VCSEL light sources in high speed dispersion compensation system
Authors: Haritha Thotakura , Thulasi Bai Archana Babu , Sudhakar Jayavel , Krishnan Kannan , Prabu Ramachandran Thandaiah , Anwer Karem Tarek , Hossain Md. Amzad 
Published: September 2023

Abstract
This paper demonstrated the efficient employment of vertical cavity surface emitting laser (VCSEL) light sources in high speed dispersion compensation systems. VCSEL are compared with CW laser and distributed feedback laser in the modulated light output power, signal quality factor and minimum data error rates through the fiber system. Light signal base band modulated power is clarified with spectral frequencies after LiNb MZ modulators. Light signal base band modulated amplitude is simulated against base band time frequencies after LiNb MZ modulators. The total light signal index base band modulated power/amplitude value is estimated after LiNb MZ modulators for various light sources. The light signal base band modulated power is demonstrated with both spectral frequencies and time interval after fiber loop control length with compensation system. Total light signal index base band modulated power/amplitude value is estimated numerically after fiber loop control length with compensation system. The modulated electronic signal base band modulated power is indicated with spectral frequencies after PIN receiver. The light signal base band modulated amplitude is studied clearly against base band time frequencies after PIN receiver. The signal quality factor, BER, and modulated lighted output power are clarified and sketched against fiber system lengths for various light sources.
First-principles study of the radiolytic degradation of diglycolamides
Authors: Verlinden Bart , Van Hecke Karen , Wilden Andreas , Modolo Giuseppe , Binnemans Koen , Cardinaels Thomas , Kowalski Piotr M. 
Published: September 2023

Abstract
Understanding the degradation mechanisms of organic compounds in an extreme radiolysis induced environment is important for designing efficient organic extractants for the separation of radionuclides from used nuclear fuel. In this paper, we present an in-depth computational chemistry-based molecular level analysis of the radiolytic degradation of diglycolamides, with a focus on structural and thermodynamic aspects of the process. The most vulnerable parts of the organic ligands prone to attack and degradation by radicals are identified via electronic density and bond strength analysis. We identified the C–O of the ether group as the weakest bond, which is further weakened by methylation. A plausible degradation path resulting from breaking the C–O bond by H radical attack is obtained by computation of free energy of the process. To investigate realistic reaction conditions, we accounted for the impact of solvation effects on the thermodynamic quantities, including solvation entropy effects. The resulting degradation mechanism is consistent with experimentally observed degradation products.
Dark Web Drug Markets and Cartel Crime
Authors: Meehan Brian , Farmer Nicholas 
Published: September 2023

Abstract
Recent evidence suggests that legal marijuana markets in several U.S. states have decreased violence in Mexican-U.S. border regions. As legal markets for production and distribution displace drug cartel distribution, the violence associated with cartel trafficking and distribution decreases. Prior analysis has not considered an important emerging innovation for drug distribution: online anonymous marketplaces. The increasing volume of drug trade that has occurred on this “Dark Web” could result in reduced drug cartel violence as production and distribution use this substitute network and turn away from the cartel distribution networks. This paper investigates the relationship between border violence and the volume of drug trade that occurs on the Dark Web using a difference in differences model. We examine differences in crime rates at the U.S.-Mexico border and away from the border during the emergence of the Dark Web. Data on Dark Web transactions, users, and markets allows us to measure changes in Dark Web activity and the subsequent impact on crime. We find evidence that the rise in Dark Web marketplaces results in crime reductions at the border of the U.S., relative to non-border counties.
Combined matrix of diagonally equipotent matrices
Authors: Bru Rafael , Gassó Maria T. , Giménez Isabel , Santana Máximo , Scott José 
Published: September 2023

Abstract
Let

C

(

A

)

=
A

∘

A

−
T

{\mathcal{C}}\left(A)=A\circ {A}^{-T}

be the combined matrix of an invertible matrix

A

A

, where

∘

\circ

means the Hadamard product of matrices. In this work, we study the combined matrix of a nonsingular matrix, which is an

H

H

-matrix whose comparison matrix is singular. In particular, we focus on

C

(

A

)

{\mathcal{C}}\left(A)

when

A

A

is diagonally equipotent, and we study whether

C

(

A

)

{\mathcal{C}}\left(A)

is an

H

H

-matrix and to which class it belongs. Moreover, we give some properties on the diagonal dominance of these matrices and on their comparison matrices.
Rhesus factor is a stronger predictor for the risk of Sars-CoV-2 and mortality than ABO blood types
Authors: Yesilyurt Soner , Erinc Osman , Senat Almila , Gezmis Cem Tugrul , Balci Mustafa Bahadir Can 
Published: September 2023

Abstract

Objectives
In this study, we aimed to evaluate the relationship between ABO blood groups and Rhesus factor (Rf) and severe acute respiratory syndrome coronavirus-2 (Sars-CoV-2), as well as the risk of infection susceptibility and death according to pre-existing comorbidities.

Methods
This retrospective study included patients medical record between March 2020 and March 2021. A total 470 patients were included in the study. The subjects were categorized according to diagnose of Sars-CoV-2. Also, we evaluated the subject according to severity of Sars-CoV-2 infection. The logistic and multivariate regression analysis were performed to predict possible effect of ABO and Rf types as well as comorbidities on indicators of Sars-CoV-2 severity including Intensive care unit (ICU) hospitalization, intubation, and mortality.

Results
The distribution of ABO blood type and Rf were not statistically different cases with and without Sars-CoV-2. Blood type B and A were the most groups in intubation and mortality among patients with Sars-CoV-2. However, ABO blood types had no significant effect on risk of Sars-CoV-2 and mortality while, Rf had a significantly effect on it. Additionally, Rf had a statistically significant effect on all severity indicators of Sars-CoV-2 but ABO had not.

Conclusions
While Rf was significantly associated with risk of Sars-CoV-2 and had a strong effect on ICU admission, intubation, and mortality, ABO groups were not associated with risk of disease. Intubation and mortality rates were higher in patients with blood group B (OR: 2.93 p:0.390 95 % CI [0.253–33.9], OR: 0.217 p:0.211 95 % CI [0.020–2.37]) and Rh factor + (OR: 1.63 p:0.027 95 % CI [0.046–0.828]).
Electrocatalytic hydrogen evolution at carbon paste electrodes doped with a manganese(II) imidazoledicarboxylate complex
Authors: Wu Zhengwei , Wan Tiantian , Kong Xiaoxia , Shen Qinqin , Li Kaiyi , Wu Huilu 
Published: September 2023

Abstract
A mononuclear Mn(II) complex [Mn(p-MOPhH2IDC)2(H2O)2]·2(DMF), was synthesized by the reaction of p-MOPhH3IDC (2-(4-methoxyphenyl)-1H-imidazole-4,5-dicarboxylic acid) and Mn(CH3COO)2·4H2O under solvothermal conditions and characterized by single-crystal X-ray diffraction, elemental analysis, IR and UV–vis spectroscopy. The structure analysis revealed that the manganese(II) center has a six-coordinated octahedral coordination geometry. The performance of a Mn(II) complex-doped carbon paste electrode (Mn-CPE) in the electrocatalytic hydrogen evolution reaction (HER) was evaluated by linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) methods. The polarization curve shows that the η
10
298K (overpotential, 10 mA cm−2) of the Mn-CPE was positively shifted by 341 mV compared with the bare CPE (without complex). The Tafel slope of the Mn-CPE was 161 mV dec−1. These data indicate that the Mn-CPE was effective in the HER electrocatalytic reaction. For EIS experiments, the arc diameter of the high-frequency region of the Mn-CPE was much smaller than that of the bare CPE, which further indicates the effective catalytic capacity of the Mn(II) complex for hydrogen evolution. The information obtained from this study will help to expand the application of Mn(II) complexes in the field of electrochemistry.
How Sucrose Preference Is Gained and Lost: An In-Depth Analysis of Drinking Behavior during the Sucrose Preference Test in Mice
Authors: Wulff Andreas B. , Cooper Phylicia , Kodjo Emmanuela , Abel Eliana , Thompson Scott M. 
Published: September 2023

AbstractThe sucrose preference test (SPT) is a widely used preclinical assay for studying stress-sensitive reward behaviors and antidepressant treatments in rodents, with some face, construct, and predictive validity. However, while stress-induced loss of sucrose preference is presumed to reflect an anhedonic-like state, little detail is known about what behavioral components may influence performance in the SPT in stress-naive or stressed rodents. We analyzed the licking microstructure of mice during the SPT to evaluate how preference is expressed and lost following chronic stress. In stress-naive mice, preference is expressed as both longer and more numerous drinking bouts at the sucrose bottle, compared with the water bottle. We also found evidence that memory of the sucrose bottle location supports preference. Through manipulations of the caloric content of the sweetener or caloric need of the mouse, we found that energy demands and satiety signals do not affect either preference or the underlying drinking behavior. Both acute and chronic stress impaired sucrose location memory and reduced the number of drinking bouts at the sucrose bottle, the latter of which explained the loss of sucrose preference in stress susceptible mice compared with stress resilient mice. Female mice generally exhibited similar drinking behavior to male mice but may be less susceptible to chronic stress and display better memory performance than male mice, both before and after chronic stress. Our data suggest that chronic stress inhibits a sucrose preference by reducing reward seeking behavior without affecting palatability.
The Mathematics of Truth
Authors: Berlin K. Avvirin 
Published: September 2023

K. Avvirin Berlin, “The Mathematics of Truth: Peripatetic Freedom Calculations in the Narrative of Sojourner Truth” (pp. 114–141)
This essay reads passages in the Narrative of Sojourner Truth, a Northern Slave (1850) that pertain to walking and Black motherhood. In doing so, it theorizes Truth’s 1843 walking migration as a political pilgrimage whose spatial-temporal schema challenged federal and state policy. Armed with tactics borrowed from mathematics and the natural sciences, “sojourner laws” and other federal dictates worked to confine African American mothers like Truth to particular social and geographic places and to their status as enslaved and low-wage laborers. Casting a critical eye on Truth’s white feminist co-author Olive Gilbert’s representations of motherhood in the Narrative of Sojourner Truth, “The Mathematics of Truth” seeks to intervene into the reception of Truth’s life and politics.
Legal Formulation of Telemedicine Implementation as the Prevention of Malpractice Risk for Patients
Authors: Nasution Fatihana Ulya , Ibrahim Aji Lukman 
Published: September 2023

This study aims to determine the practice of implementing telemedicine in Indonesia and legal reformulation in telemedicine implementation as a prevention of malpractice risks to patients. This study used normative juridical research, with the statute approach, conceptual approach, and comparative approach. The data used is secondary data consisting of primary legal materials, secondary legal materials, and tertiary legal materials. The results of this study indicate that Indonesia does not yet have regulations that specifically regulate the use of telemedicine. Regulation of the Minister of Health Number 20 of 2019 is not sufficient to guide the implementation of telemedicine in Indonesia. Thus, the use of telemedicine has the potential to cause various legal problems. If referring to the principles of medical practice, telemedicine can pose a risk of malpractice to patients because doctors do not examine patients directly. Not only that, current regulations also do not specifically regulate the concept of administering electronic medical records in telemedicine, thus increasing the risk of malpractice in the form of leakage of electronic medical record data and resulting in legal uncertainty in proving in the event of malpractice. Therefore, it is necessary to reformulate the law by issuing telemedicine regulations whose substance regulates the relationship between doctors and patients, the rights and obligations of the parties, protection of electronic medical records, criminal sanctions, and an independent supervisory institution.
Keywords: Legal Reformulation, Malpractice, Telemedicine.
Prevention of Motor Vehicle Theft by the Samapta Patrol (Study at the Demak Resort Police)
Authors: Syabrina Lesha 
Published: September 2023

This study is to describe the samapta patrol units and efforts increased by the Demak Police samapta unit. This type of research uses a field of research and a qualitative approach. Data sources include primary data and secondary data with data collection techniques used are interviews, observations, and document studies Data analysis techniques used include data reduction, data presentation and conclusion drawing. Knife analysis in conducting discussions includes POAC theory and management theory. The results of the study found that curanmor crimes had fluctuated over the past three years, patrol activities carried out by the Samapta Unit of the Demak Police were carried out according to the SOP, divided into four stages, namely preparation stage, organization stage, implementation stage andevaluation/ termination stage. Some actors are inadequate and external facilities and infrastructure are the jurisdiction of the Demak Police which is quite wide and the intentions of criminals are difficult to predict. Based on the results of the study, the author suggests that in the creation of patrol routes always pay attention to the development of the last Kamtibmas situation in Kabupaten Demak. Often establish cooperation with the community, such as Hansip post, Kamra post, Security Guard post, and Kamling post selectively to facilitate monitoring locations prone to theft of motor vehicles and patrols through residential areas of the community.
Quality of fresh and cryopreserved bovine sperm is reduced by BPA and BPF exposure
Authors: Davis Ola S , Truong Vivien B , Hickey Katie D , Favetta Laura A 
Published: September 2023

Bisphenol A (BPA) is an endocrine-disrupting compound, used as the key monomer of polycarbonate plastics and epoxy resins. BPA has been detected in both humans and farm animals and has been correlated with decreased sperm counts and motility. BPS and BPF are structural analogs of BPA and are increasingly being used in manufacturing as BPA substitutes. In this study, we aim to assess the direct outcomes of BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure on bovine sperm parameters in vitro to elucidate how they affect sperm quality and fertilization potential, and to assess whether BPS and/or BPF are less harmful than BPA. Sperm from three or more bulls was obtained from either fresh samples or cryopreserved straws and exposed to 0.05 mg/mL of BPA, BPS, and BPF in vitro. After 4 h incubation, motility, capacitation, apoptosis/necrosis, and mitochondrial membrane potential levels were measured by computer-assisted sperm analysis or computational flow cytometry. Results showed that BPA exposure significantly reduced both fresh and cryopreserved sperm motility, capacitation, viability and mitochondrial membrane potential levels. Furthermore, BPF significantly decreased motility, capacitation and mitochondrial membrane potential in cryopreserved sperm only. BPS did not have any significant effects on any of the parameters measured. Our results suggest that BPA is the most harmful to sperm, while BPF is toxic under certain conditions, and BPS seems to be the least detrimental. Overall, this study provides an understanding of how the ubiquitous environmental chemicals, bisphenols, may impact male fertility even after ejaculation.

Lay summary
Bisphenol A (BPA) is a widespread man-made compound found in plastic products and the environment, and has been detected in human and animal biological fluids. BPA has been previously investigated for its negative effects on health, including its detrimental impacts on reproductive cells. Concerns over the use of BPA has led to its ban in some countries and has introduced the use of ‘BPA-free’ products, which typically contain substitutes such as bisphenols S and F (BPS and BPF). This current study investigates the effects of bull sperm exposure to BPA, BPS, and BPF to evaluate their impacts on sperm quality. After exposure, both BPA and BPF lowered sperm mobility, organelle function (by reducing mitochondrial activity), and overall survival; while BPS had no effects. Overall, this study shows that BPA and its common replacement, BPF, can both act on sperm directly, reducing their overall quality and function.