bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forming-based geometric correction methods for thin-walled metallic components: a selective review
Authors: Zhou Xianyan , Ma Jun , Zhou Wenbin , Welo Torgeir 
Published: July 2023

AbstractGeometric correction processes contribute to zero-defect manufacturing for improved product quality. Thin-walled metallic components are widely used in numerous applications such as electric vehicles and aircraft due to the lightweight feature, facilitating to achieve zero-emission goals. However, many components suffer geometric imperfections and inaccuracies such as undesired curvatures and twists, seriously affecting subsequent manufacturing operations, for example, automatic welding and assembly. Geometric correction techniques have been established to address these issues, but they have drawn little attention in the scientific community despite their wide applications and urgent demands in the industry. Due to the strict geometric tolerances demanded in high-volume automated production, it is urgent to increase the knowledge needed to develop new techniques to address future industrial challenges. This review paper presents an overview of typical geometric defects in thin-walled components and clarifies the associated underlying generation mechanisms. Attempts have also been made to discuss and categorize geometric correction techniques based on different forming mechanisms. The challenges in correcting complex thin-walled products are discussed. This review paper also provides researchers and engineers with directions to find and select appropriate geometric correction methods to achieve high geometric accuracy for thin-walled metallic components.
Confocal micro X-ray fluorescence analysis for the non-destructive investigation of structured and inhomogeneous samples
Authors: Heimler Korbinian , Gottschalk Christine , Vogt Carla 
Published: July 2023

AbstractConfocal micro X-ray fluorescence (CMXRF) spectroscopy is a non-destructive, depth-resolved, and element-specific technique that is used to analyze the elemental composition of a sample. For this, a focused beam of mono- or polychromatic X-rays is applied to excite the atoms in the sample, causing them to emit fluorescence radiation which is detected with focusing capillary optics. The confocal design of the instrument allows for depth-resolved analysis, in most cases with a resolution in the lower micrometer dimension after collecting X-rays from a predefined volume within the sample. The element-specific nature of the technique allows information to be obtained about the presence and concentration of specific elements in this volume. This makes CMXRF spectroscopy a valuable tool for a wide range of applications, especially when samples with an inhomogeneous distribution of elements and a relatively light matrix have to be analyzed, which are typical examples in materials science, geology, and biology. The technique is also commonly used in the art and archaeology fields to analyze the elemental composition of historical artifacts and works of art, helping to provide valuable insights into their provenance, composition, and making. Recent technical developments to increase sensitivity and efforts to improve quantification in three-dimensional samples will encourage wider use of this method across a multitude of fields of application in the near future.
Graphical abstract
Confocal micro X-ray fluorescence (CMXRF) is based on the confocal overlap of two polycapillary lens foci, creating a depth-sensitive and non-destructive probing volume. Three-dimensional resolved element distribution images can be obtained by measuring the fluorescence intensity as function of the three-dimensional position.
Open Field Exercise Testing in Pediatric Congenital Heart Disease Patients: A Subsumption of Cardiovascular Parameters
Authors: Rückert J. , Michaelis A. , Markel F. , Kalden P. , Löffelbein F. , Klehs S. , Dähnert I. , Schöffl I. , Rottermann K. , Paech C. 
Published: July 2023

AbstractHeart failure is a common phenomenon in congenital heart disease patients. Cardiopulmonary exercise testing is used for a reliable assessment of heart failure but is still challenging, especially for young children. Implementing mobile cardiopulmonary exercise testing (CPET) can close that diagnostic gap. While average values for healthy children have already been published, this study aims to describe typical ranges of cardiovascular performance parameters of young children with congenital heart disease performing an 8-min running cardiopulmonary exercise test. Children aged 4–8 years with common congenital heart defects after corrective surgery (Tetralogy of Fallot; transposition of the great arteries and univentricular hearts after palliation) were included. The outdoor running protocol consisted of slow walking, slow jogging, fast jogging, and maximum speed running. Each exercise was performed for 2 min, except the last, in which children were instructed to keep up maximal speed as long as possible. A total of 78 children (45 male/33 female, mean age 6,24) with congenital heart disease participated in the study, of which 97% completed the CPET successfully. A detailed description of participating patients, including data on cardiac function and subjective fitness levels, is given to help physicians use this method to classify their patients. This study presents a typical range for cardiovascular performance parameters in a population of 4–8-year-old children with congenital heart disease tested in a newly developed outdoor running protocol for CPET.
Comparison of Four-Dimensional Flow MRI, Two-Dimensional Phase-Contrast MRI and Echocardiography in Transposition of the Great Arteries
Authors: Warmerdam Evangeline G. , Westenberg Jos J. M. , Voskuil Michiel , Rijnberg Friso M. , Roest Arno A. W. , Lamb Hildo J. , van Wijk Bram , Sieswerda Gertjan T. , Doevendans Pieter A. , ter Heide Henriette , Krings Gregor J. , Leiner Tim , Grotenhuis Heynric B. 
Published: July 2023

AbstractPulmonary artery (PA) stenosis is a common complication after the arterial switch operation (ASO) for transposition of the great arteries (TGA). Four-dimensional flow (4D flow) CMR provides the ability to quantify flow within an entire volume instead of a single plane. The aim of this study was to compare PA maximum velocities and stroke volumes between 4D flow CMR, two-dimensional phase-contrast (2D PCMR) and echocardiography. A prospective study including TGA patients after ASO was performed between December 2018 and October 2020. All patients underwent echocardiography and CMR, including 2D PCMR and 4D flow CMR. Maximum velocities and stroke volumes were measured in the main, right, and left PA (MPA, LPA, and RPA, respectively). A total of 39 patients aged 20 ± 8 years were included. Maximum velocities in the MPA, LPA, and RPA measured by 4D flow CMR were significantly higher compared to 2D PCMR (p < 0.001 for all). PA assessment by echocardiography was not possible in the majority of patients. 4D flow CMR maximum velocity measurements were consistently higher than those by 2D PCMR with a mean difference of 65 cm/s for the MPA, and 77 cm/s for both the RPA and LPA. Stroke volumes showed good agreement between 4D flow CMR and 2D PCMR. Maximum velocities in the PAs after ASO for TGA are consistently lower by 2D PCMR, while echocardiography only allows for PA assessment in a minority of cases. Stroke volumes showed good agreement between 4D flow CMR and 2D PCMR.
“Sandwich” protocol based on modified SMILE regimen for children with newly extranodal NK/T cell lymphoma, nasal type: a single-arm, single-center clinical study
Authors: Shen Cheng-qi , He Guo-qian , Wan Zhi , Lin Chao , Yang Xue , Lu Xiao-xi , Zhu Yi-ping , Gao Ju , Guo Xia 
Published: July 2023

AbstractExtranodal NK/T-cell lymphoma, nasal type (ENKTL), which is a rare form of mature T/NK cell lymphoma in children, currently lacks a standardized first-line treatment approach. However, a treatment protocol known as the “sandwich” regimen has been used in children newly diagnosed with ENKTL. This protocol combines the administration of methotrexate, ifosfamide, etoposide, pegaspargase, and dexamethasone (referred to as SMILE) with the addition of radiotherapy (RT). From September 2017 to December 2020, a total of five patients were included in the study, consisting of three males and two females. The median age of onset was 10.6 years (range, 9.8 to 14.0 years). Among the patients, four had nasal/nasopharyngeal disease at stage II, while one patient had extra nasal disease involving the skin at stage IV. The median EBV-DNA level in plasma was 1.68 × 103 copies/ml (range, 0.44 to 21.1 × 103copies/ml). All the patients had good overall response after 2 cycles of chemotherapy and radiotherapy, including 4 of the patients who had a complete response and 1 of the patients with partial remission. The patient with stage IV received allogeneic hematopoietic stem cell transplantation after the EBV-DNA level was elevated again during treatment. One patient in the low-risk group experienced grade 4 oral mucositis, while no other severe complications or treatment-related deaths were observed. The median follow-up period was 22 months (range, 5 to 57 months). All five patients successfully completed their treatment, with four patients achieving event-free survival, and one patient was lost to follow-up. The median OS time and EFS time was 33 months (range: 18–57 months) and 20 months (range: 5–47 months), respectively. The sandwich protocol has demonstrated a high response rate, good tolerance to chemotherapy, and no treatment-related fatalities. However, further confirmation is necessary through additional clinical studies involving larger sample sizes. Clinical trial registration number: Due to modified SMILE regimens with sandwiched radiotherapy yielded promising outcomes in children ENKTL, we have carried out a phase II multicenter clinical trial (ChiCTR220005954) for children ENKTL in China to further verify the efficacy and safety.
Vector Field Models for Nematic Disclinations
Authors: Acharya Amit , Fonseca Irene , Ganedi Likhit , Stinson Kerrek 
Published: July 2023

AbstractIn this paper, a model for defects in nematic liquid crystals that was introduced in Zhang et al. (Physica D Nonlinear Phenom 417:132828, 2021) is studied. In the literature, the setting of many models for defects is the function space SBV (special functions of bounded variation). However, the model considered herein regularizes the director field to be in a Sobolev space by introducing a second vector field tracking the defect. A relaxation result in the case of fixed parameters is proved along with some partial compactness results as the defect width vanishes.
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
Authors: Aly Amr , Laszlo Zsofia I. , Rajkumar Sandeep , Demir Tugba , Hindley Nicole , Lamont Douglas J. , Lehmann Johannes , Seidel Mira , Sommer Daniel , Franz-Wachtel Mirita , Barletta Francesca , Heumos Simon , Czemmel Stefan , Kabashi Edor , Ludolph Albert , Boeckers Tobias M. , Henstridge Christopher M. , Catanese Alberto 
Published: July 2023

AbstractAmyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly affecting upper and lower motoneurons. Several functionally heterogeneous genes have been associated with the familial form of this disorder (fALS), depicting an extremely complex pathogenic landscape. This heterogeneity has limited the identification of an effective therapy, and this bleak prognosis will only improve with a greater understanding of convergent disease mechanisms. Recent evidence from human post-mortem material and diverse model systems has highlighted the synapse as a crucial structure actively involved in disease progression, suggesting that synaptic aberrations might represent a shared pathological feature across the ALS spectrum. To test this hypothesis, we performed the first comprehensive analysis of the synaptic proteome from post-mortem spinal cord and human iPSC-derived motoneurons carrying mutations in the major ALS genes. This integrated approach highlighted perturbations in the molecular machinery controlling vesicle release as a shared pathomechanism in ALS. Mechanistically, phosphoproteomic analysis linked the presynaptic vesicular phenotype to an accumulation of cytotoxic protein aggregates and to the pro-apoptotic activation of the transcription factor c-Jun, providing detailed insights into the shared pathobiochemistry in ALS. Notably, sub-chronic treatment of our iPSC-derived motoneurons with the fatty acid docosahexaenoic acid exerted a neuroprotective effect by efficiently rescuing the alterations revealed by our multidisciplinary approach. Together, this study provides strong evidence for the central and convergent role played by the synaptic microenvironment within the ALS spinal cord and highlights a potential therapeutic target that counteracts degeneration in a heterogeneous cohort of human motoneuron cultures.
Hero and the tradition of the circle segment
Authors: Mendell Henry 
Published: July 2023

AbstractIn his Metrica, Hero provides four procedures for finding the area of a circular segment (with b the base of the segment and h its height): an Ancient method for when the segment is smaller than a semicircle, $$(b + h)/2 \, \cdot \, h$$

(
b
+
h
)
/
2

·

h

; a Revision, $$(b + h)/2 \, \cdot \, h + (b/2)^{2} /14$$

(
b
+
h
)

/
2

·

h
+

(
b
/
2
)

2

/
14

; a quasi-Archimedean method (said to be inspired by the quadrature of the parabola) for cases where b is more than triple h, $${\raise0.5ex\hbox{$\scriptstyle 4$} \kern-0.1em/\kern-0.15em \lower0.25ex\hbox{$\scriptstyle 3$}}(h \, \cdot \, b/2)$$

4

/

3

(
h

·

b
/
2
)

; and a method of Subtraction using the Revised method, for when it is larger than a semicircle. He gives superficial arguments that the Ancient method presumes $$\pi = 3$$

π
=
3

and the Revision, $$\pi = {\raise0.5ex\hbox{$\scriptstyle {22}$} \kern-0.1em/\kern-0.15em \lower0.25ex\hbox{$\scriptstyle 7$}}$$

π
=

22

/

7

. We are left with many questions. How ancient is the Ancient? Why did anyone think it worked? Why would anyone revise it in just this way? In addition, why did Hero think the Revised method did not work when $$b > 3\;h$$

b
>
3

h

? I show that a fifth century BCE Uruk tablet employs the Ancient method, but possibly with very strange consequences, and that a Ptolemaic Egyptian papyrus that checks this method by comparing the area of a circle calculated from the sum of a regular inscribed polygon and the areas of the segments on its sides as determined by the Ancient method with the area of the circle as calculated from its diameter correctly sees that the calculations do not quite gel in the case of a triangle but do in the case of a square. Both traditions probably could also calculate the area of a segment on an inscribed regular polygon by subtracting the area of the polygon from the area of the circle and dividing by the number of sides of the polygon. I then derive two theorems about pairs of segments, that the reviser of the Ancient method should have known, that explain each method, why they work when they do and do not when they do not, and which lead to a curious generalization of the Revised method. Hero’s comment is right, but not for the reasons he gives. I conclude with an exploration of Hero’s restrictions of the Revised method and Hero’s two alternative methods.
Clinical exome sequencing elucidates underlying cause of death in sudden unexpected death of infants: two case reports
Authors: Heathfield Laura Jane , Martin Lorna Jean , van der Heyde Yolande , Molefe Itumeleng , Ramesar Raj 
Published: July 2023

AbstractSudden unexpected death in infants (SUDI) is a traumatic event for families, and unfortunately its occurrence remains high in many parts of the world. Whilst cause of death is resolved for most cases, others remain undetermined following postmortem investigations. There has been a recognition of the role of genetic testing in unexplained cases, where previous studies have demonstrated the resolution of cases through DNA analyses. Here we present two case reports of SUDI cases admitted to Salt River Mortuary, South Africa, and show that underlying causes of death were determined for both infants using clinical exome sequencing. The first infant was heterozygous for a variant (rs148175795) in COL6A3, which suggested a bronchopulmonary dysplasia phenotype. This hypothesis led to finding of a second candidate variant in DMP1 (rs142880465), which may contribute towards a digenic/polygenic mechanism of a more severe phenotype. Histological analysis of retained tissue sections showed an asphyxial mechanism of death, where bronchiolar muscle weakness from an underlying bronchopulmonary dysplasia may have contributed to the asphyxia by affecting respiration. In the second infant, a homozygous variant (rs201340753) was identified in MASP1, which was heterozygous in each parent, highlighting the value of including parental DNA in genetic studies. Whilst mannose-binding lectin deficiency could not be assessed, it is plausible that this variant may have acted in combination with other risk factors within the triple-risk model to result in sudden death. These results may have genetic implications for family members, and represent possible new candidate variants for molecular autopsies.
Contrasting intra-individual variation in size-based trophic and habitat shifts for two coastal Arctic fish species
Authors: Pettitt-Wade Harri , Hussey Nigel E. , Gallagher Colin P. , Lea Ellen V. , Orrell Danielle L. , Loseto Lisa L. 
Published: July 2023

AbstractWithin and among species variation in trophic and habitat shifts with body size can indicate the potential adaptive capacity of species to ecosystem change. In Arctic coastal ecosystems, which experience dramatic seasonal shifts and are undergoing rapid change, quantifying the trophic flexibility of coastal fishes with different migratory tactics has received limited attention. We examined the relationships among body length and condition (Fulton’s K, phase angle from Bioelectrical Impedance Analysis) with trophic and habitat shifts (differences in δ15N and δ13C between blood tissues with different turnover rates) of two abundant and culturally important species, anadromous Arctic char (Salvelinus alpinus, n = 38) and sedentary Greenland cod (Gadus ogac, n = 65) during summer in coastal marine waters near Ulukhaktok, Northwest Territories, Canada. Habitat shifts (δ13C) increased with length (i.e., pelagic to benthic-littoral) and crossed-equilibrium (zero) at mid-sizes for both species. Seasonal trophic shifts (δ15N) were generally positive (i.e., increasing trophic level) for Arctic char and negative for Greenland cod. As hypothesised, intra-individual variation in size-based trophic shifts (δ15N-length residuals) increased with length for Arctic char. However, there were no trends with length in Greenland cod. Our findings highlight the importance of flexibility through ontogeny and mobility for Arctic char, whereas Greenland cod were generalist to localized prey and habitat across all sizes. The significant effect of body condition (phase angle) on size-based trophic shifts in Arctic char, and size-based habitat shifts in Greenland cod, highlight the potential trade-offs of contrasting life history strategies and capacity for ontogenetic niche plasticity.
Feasibility of on-demand robotics in colorectal surgery: first cases
Authors: Hahnloser Dieter , Rrupa Djana , Grass Fabian 
Published: July 2023

Abstract
Introduction
The key benefits of robotics are improved precision and control, thanks to fully articulated robotic instruments and enhanced, stable endoscope control. However, colorectal procedures also require large movements such as medialization of the colon where a robotic platform is not always needed. We present the world’s first experience in colorectal surgery with a new open platform of on-demand robotics.

Methods and procedures
Standard laparoscopic 3-D camera, insufflator, trocars and energy devices, available in all hospitals performing laparoscopic surgery, are used in combination with the Dexter System™ from Distalmotion SA, which includes two robotic instrument arms, one robotic endoscope arm and a sterile surgeon console. We present the first 12 colorectal cases of robotic assisted ventral mesh rectopexy (n = 2), oncologic right colectomies (n = 8), transverse colectomy (n = 1) and ileocecal resection (n = 1) using the Dexter System.

Results
The two ventral mesh rectopexies were fully robotic, requiring no switching from standard laparoscopy to robotic assistance. The robotic platform was used for central vascular ligation (CVL) in all 8 oncologic colectomies, whereas medialization of the colon and transection was performed with standard laparoscopy. The switch from laparoscopy to robotics and back was performed in 15–30 s. Intracorporal anastomosis was performed in 4 patients (stapling by standard laparoscopy and suturing of the defect with robotic assistance). Conversion or permanent switch to standard laparoscopy was required in two patients due to visceral obesity. No robotic platform-related intraoperative adverse event occurred. No major morbidity occurred at 60 days.

Conclusions
On-demand robotics is feasible and combines the best of two worlds: Robotics where precision and enhanced dexterity are required and standard laparoscopy where it is at its best. The surgeon remains scrubbed-in at all times, allowing a switch between robotics and laparoscopy within seconds.
Positive effects of the COVID-19 pandemic on depression and anxiety in Chinese adolescents
Authors: Yang Xinhua , Lawrence Andrew J. , Harrison Phillippa , Liu Yanlong , Chen Liangliang , Wang Chenglei , Yan Chao , Zahn Roland 
Published: July 2023

AbstractThe potential impact on mental health of home schooling and social isolation due to COVID-19 lockdowns has led to widespread concern, particularly for adolescents. However, studies including pre-pandemic data from longitudinal cohorts with an assessment of the longer-term impact of the Covid-19 pandemic beyond the first months of 2020 are scarce. This longitudinal study of 1534 adolescents attending a secondary school in Hunan province investigated self-reported symptoms of anxiety and depression using two validated scales (Screen for Child Anxiety Related Disorders, Child Mood and Feelings Questionnaire) at six time points before, during, and after the 2020 national lockdown restrictions in China. Perceived COVID-related stress was assessed by an author-developed scale at two timepoints during the lockdown. We investigated trends in symptoms over time with a fixed effects model and multiple imputations of missing data. Counter to our expectations, depressive and anxiety symptoms were reduced during the 2020 lockdown relative to pre-lockdown (depression: b = − 3.37, SE = 0.345, Cohen’s d = − 0.25, p < 0.0001; anxiety: b = − 4.55, SE = 0.382, Cohen’s d = − 0.30, p < 0.0001). Symptoms remained significantly reduced even after lockdown restrictions eased. Higher symptom levels during lockdown were associated with greater self-reported COVID-related stress (depression: b = 0.11, SE = 0.026, p < 0.0001; anxiety: b = 0.11, SE = 0.036, p < 0.0001). Although COVID-related stresses correlated with higher levels of anxiety and depression, the lockdown period was associated with improved symptom levels in the adolescents taking part in our study. School closures may have improved the mental health of adolescents in China. We speculate this beneficial effect of lockdown can be explained by the adverse effects of attending school itself such as exposure to bullying and achievement pressures.