bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the multiattempt minimal repair and the corresponding counting process
Authors: Cha Ji Hwan , Finkelstein Maxim 
Published: September 2023

AbstractMinimally repaired items are considered. In practice, minimal repair can be unsuccessful, and in this case, it should be repeated. The Polya‐Aeppli process, which is a generalization of the Poisson process is used in the article for the corresponding modeling. Some properties, useful for optimal maintenance, are derived. An important generalization to the case when the probability of the unsuccessful attempt is time‐dependent is described. An application of the derived results to obtaining the optimal time of replacement for a system with multiattempt minimal repairs is discussed. The study is illustrated by detailed numerical examples.
Multi‐Akteur‐Fabrikation im Bauwesen
Authors: Amtsberg Felix , Yang Xiliu , Skoury Lior , Ron Gili , Kaiser Benjamin , Sousa Calepso Aimée , Sedlmair Michael , Verl Alexander , Wortmann Thomas , Menges Achim 
Published: September 2023

AbstractDie aktuelle Generation von Planern ist mit der Aufgabe konfrontiert, neue, nachhaltigere Bausysteme zu entwickeln, um der Problematik der Ressourcenknappheit, der Verstädterung, dem Klima‐, aber auch dem demografischen Wandel entgegenzuwirken. Hierbei ist die Frage nach deren effizienter Herstellung unter Nutzung nachwachsender Rohstoffe in den Fokus der Forschungsbemühungen gerückt. In den letzten Jahren hat der Automatisierungsgrad in der Vorfertigung unter der Agenda der produktbasierten Bausysteme zugenommen, die ein hohes Potenzial aufweisen, aber in Umgebungen, wo eine höhere Flexibilität erforderlich ist, nur bedingt zielführend sind. Die Realisierung ressourcensparender Entwürfe führt unweigerlich zu kleinen Losgrößen und einmalig zu produzierenden Bauelementen, die für eine effiziente Fabrikation anpassungsfähige Vorfertigungsanlagen für eine Vielzahl von Lösungen erfordern. Am Exzellenzcluster Integratives computerbasiertes Planen und Bauen für die Architektur (IntCDC) werden Methoden erforscht, welche mittels Mensch‐Maschine‐Kollaboration eine Steigerung von Flexibilität und Adaptivität der Vorfabrikation und Konstruktion von Bauwerken anstreben. Dazu werden neben der Durchführung von Untersuchungen zur Augmented‐Reality‐Technologie‐unterstützten Integration und Kommunikation von Mensch und Maschine auch auf maschinellem Lernen basierende Trainingsmethoden und Vorhersagemodelle entwickelt.
Rhombohedral (R) Prussian White as Cathode Material: An Ab‐initio Study
Authors: Baumgart Sebastian , Sotoudeh Mohsen , Groß Axel 
Published: September 2023

AbstractPrussian Whites (PW) have gained attention for their potential application as high energy density cathodes in Na‐ion batteries. However, the rhombohedral phase of this compound still remains elusive. This study addresses the electronic and structural properties of the rhombohedral host material, as well as its ionic conductivity. Using periodic density functional theory calculations, we identified the critical factors that determine the sodium‐ion site preference and their ionic mobility. Specifically, the significant role of octahedral tilting and trigonal distortions of the structure have been highlighted. The study shows that the competition between coordination and bond length governs the Na site preference in the rhombohedral phase upon distortion. The results furthermore suggest that the redox activity is dominated by the transition metals. These findings provide insight into the fundamental mechanisms underlying ionic conductivity in solid hosts and could help enhance ion transport in battery electrodes.
The influence of moisture on the sieving performance of lignocellulosic biomass
Authors: Varela Alejandro , Castillo‐Ruiz Francisco J. , Arbizu‐Milagro Julia , Tascón Alberto 
Published: September 2023

AbstractSieving is an important operation for sorting solid particles both in industry and the laboratory. Although sorting is necessary for almost every process or energy conversion applied to biomass materials, sieving has not received enough scientific attention. The aim of this study was to obtain experimental data on the sieving performance of biomass materials. Three different biomasses – two wood pellets from the same species but each one obtained from a different process, plus a poplar sawdust residue – were sieved using a laboratory sieve shaker before milling with a hammer mill. Samples with three different levels of moisture were also studied: non‐dried, dried for 1.5 h at 75 °C, and dried for 3 h at 75 °C. The results were unexpected because the three samples showed quite different behaviors. A slight drying before sieving significantly enhanced the sieving performance of one of the wood pellets but its effect on the poplar sawdust was just the opposite; in the case of the other type of wood pellets, the effect was intermediate, because it improved the sieving performance but only for a short time and for the finest fraction. These results suggest the importance of conducting a preliminary study of the material to be sieved to save energy, time, and effort. Further research in this area is still necessary to understand the influence of variables in order to reduce blinding during biomass sieving.
A fluorescent magnetic nanosensor for imidacloprid based on the incorporation of polymer dots and Fe3O4 nanoparticles into the covalent organic framework
Authors: Haghighi Shishavan Yalda , Amjadi Mohammad , Manzoori Jamshid L. 
Published: September 2023

AbstractA magnetic nanoprobe was designed for imidacloprid by encapsulating nonconjugated polymer dots (NCPDs) and Fe3O4 nanoparticles in the covalent organic framework (COF). The fluorescence intensity of the COF‐based nanocomposite is markedly suppressed by imidacloprid. As the absorption spectrum of imidacloprid was close to the band‐gap of the NCPDs, and due to the presence of a nitro group (as an electron acceptor), the electrons can be easily transferred from the conduction band of NCPDs to the LUMO of imidacloprid, so fluorescence quenching was more likely to have been caused by the electron transfer process. The COF‐based nanosensor was used for the determination of imidacloprid in the linear range 1.3–130 nM with a detection limit of 1.2 nM. The high sensitivity of the nanoprobe for imidacloprid is due to the combination of COF benefits (accumulation of the imidacloprid into the COF cavities) and the high adsorption ability of the Fe3O4 nanoparticles, which leads to further enrichment of imidacloprid. The magnetic nature of the nanocomposite enables the preconcentration and easy separation of the analyte, and so reduces matrix interference and lowers the detection limits. The practicality of this nanoprobe was confirmed by quantification of imidacloprid in the wastewater and fruit juice samples.
Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto‐parietal network in adolescents with internet addiction
Authors: Wang Yang , Qin Yun , Li Hui , Yao Dezhong , Sun Bo , Gong Jinnan , Dai Yu , Wen Chao , Zhang Lingrui , Zhang Chenchen , Luo Cheng , Zhu Tianmin 
Published: September 2023

AbstractBackgroundInternet addiction (IA), recognized as a behavioral addiction, is emerging as a global public health problem. Acupuncture has been demonstrated to be effective in alleviating IA; however, the mechanism is not yet clear. To fill this knowledge gap, our study aimed to investigate the modulatory effects of acupuncture on the functional interactions among the addiction‐related networks in adolescents with IA.MethodsThirty individuals with IA and thirty age‐ and sex‐matched healthy control subjects (HCs) were recruited. Subjects with IA were given a 40‐day acupuncture treatment, and resting‐state functional magnetic resonance imaging (fMRI) data were collected before and after acupuncture sessions. HCs received no treatment and underwent one fMRI scan after enrollment. The intergroup differences in functional connectivity (FC) among the subcortical nucleus (SN) and fronto‐parietal network (FPN) were compared between HCs and subjects with IA at baseline. Then, the intragroup FC differences between the pre‐ and post‐treatment were analyzed in the IA group. A multiple linear regression model was further employed to fit the FC changes to symptom relief in the IA group.ResultsIn comparison to HCs, subjects with IA exhibited significantly heightened FC within and between the SN and FPN at baseline. After 40 days of acupuncture treatment, the FC within the FPN and between the SN and FPN were significantly decreased in individuals with IA. Symptom improvement in subjects with IA was well fitted by the decrease in FC between the left midbrain and ventral prefrontal cortex and between the left thalamus and ventral anterior prefrontal cortex.ConclusionThese findings confirmed the modulatory effects of acupuncture on the aberrant functional interactions among the SN and FPN, which may partly reflect the neurophysiological mechanism of acupuncture for IA.
A novel hierarchically hybrid structure of MXene and bi‐ligand ZIF‐67 based trifunctional electrocatalyst for zinc‐air battery and water splitting
Authors: Mane Rupali S. , Mane Suyash , Somkuwar Vaishnavi , Thombre Nitin V. , Patwardhan Anand V. , Jha Neetu 
Published: September 2023

AbstractThe development of cost‐effective and durable electrocatalysts possesses a broad spectrum of applications in sustainable energy systems. Herein, a hierarchical composite of Co‐based bi‐ligand zeolite imidazole framework (ZIF‐67) with highly conducting 2D MXene as highly efficient noble metal free electrocatalyst for electrochemical oxygen reduction reaction (ORR), complete water splitting, along with zinc‐air battery (ZAB) has been studied. ZIF‐67 is reported as an efficient electrocatalyst due to its porous structures, high surface area and atomically dispersed active metal centres while low conductivity and structural instability have been addressed by pyrolysis. In this work, structural disintegration due to temperature effect has been handled by using bi‐ligand linkers in ZIF (b‐ZIF‐67) which controls its sharp morphology and uniform mesoporous structure. This b‐ZIF‐67 has been supported on highly conducting 2D MXene material which exposes ample accessible active sites to accelerate the electroactivity of the synthesized catalyst. The resultant b‐CZIF‐67/MXene catalyst exhibits superior onset of 0.91 and 0.93 V in acidic and alkaline medium respectively for ORR. At the current density of 10 mA/cm2 catalyst shows a very low overpotential of 0.170 mV and 1.47 V for HER and OER, respectively. The excellent specific charge storage of 550.6 mAh/g was displayed by the homemade ZAB pouch.
The crosstalk between ferroptosis and anti‐tumor immunity in the tumor microenvironment: molecular mechanisms and therapeutic controversy
Authors: Zheng Yichen , Sun Lingqi , Guo Jiamin , Ma Ji 
Published: September 2023

AbstractThe advent of immunotherapy has significantly reshaped the landscape of cancer treatment, greatly enhancing therapeutic outcomes for multiple types of cancer. However, only a small subset of individuals respond to it, underscoring the urgent need for new methods to improve its response rate. Ferroptosis, a recently discovered form of programmed cell death, has emerged as a promising approach for anti‐tumor therapy, with targeting ferroptosis to kill tumors seen as a potentially effective strategy. Numerous studies suggest that inducing ferroptosis can synergistically enhance the effects of immunotherapy, paving the way for a promising combined treatment method in the future. Nevertheless, recent research has raised concerns about the potential negative impacts on anti‐tumor immunity as a consequence of inducing ferroptosis, leading to conflicting views within the scientific community about the interplay between ferroptosis and anti‐tumor immunity, thereby underscoring the necessity of a comprehensive review of the existing literature on this relationship. Previous reviews on ferroptosis have touched on related content, many focusing primarily on the promoting role of ferroptosis on anti‐tumor immunity while overlooking recent evidence on the inhibitory effects of ferroptosis on immunity. Others have concentrated solely on discussing related content either from the perspective of cancer cells and ferroptosis or from immune cells and ferroptosis. Given that both cancer cells and immune cells exist in the tumor microenvironment, a one‐sided discussion cannot comprehensively summarize this topic. Therefore, from the perspectives of both tumor cells and tumor‐infiltrating immune cells, we systematically summarize the current conflicting views on the interplay between ferroptosis and anti‐tumor immunity, intending to provide potential explanations and identify the work needed to establish a translational basis for combined ferroptosis‐targeted therapy and immunotherapy in treating tumors.
Single‐nucleotide polymorphism at alcohol dehydrogenase 1B: A susceptible gene marker in oro‐/hypopharyngeal cancers from genome‐wide association study
Authors: Chien Hui‐Tzu , Tsai Chia‐Lung , Young Chi‐Kuan , Lee Yun‐Shien , Liao Chun‐Ta , Yeh Chih‐Ching , Chao Angel , Cho Kai‐Lun , Chen Ching‐Han , Huang Shiang‐Fu 
Published: September 2023

AbstractIntroductionIn the era of precision preventive medicine, susceptible genetic markers for oro‐/hypopharyngeal squamous cell carcinoma (OPSCC) have been investigated for genome‐wide associations.Materials and MethodsA case–control study including 659 male head and neck squamous cell carcinoma (HNSCC) patients, including 331 oropharyngeal cancer, treated between March 1996 and December 2016 and 2400 normal controls was performed. A single‐nucleotide polymorphism (SNP) array was used to determine genetic loci that increase susceptibility to OPSCC.ResultsWe analyzed the allele frequencies of 664,994 autosomal SNPs in 659 HNSCC cases; 7 SNPs scattered in loci of chromosomes 5, 7, 9, 11, and 19 were significant in genome‐wide association analysis (Pc < 1.0669 × 10−7). In OPSCCs (n = 331), two clustered regions in chromosomes 4 and 6 were significantly different from the controls. We successfully identified a missense alteration of the SNP region in alcohol dehydrogenase 1B (ADH1B) (https://genome.ucsc.edu; hg38); the top correlated locus was rs1229984 (p = 1 × 10−11). Adjusted for environmental exposure, including smoking, alcohol, and areca quid, a region in chromosome 12, related to alcohol metabolism, was found to independently increase the susceptibility to OPSCC. The ADH1B rs1229984 AA genotype had better overall survival compared to the AG and GG genotypes (p = 0.042) in OPSCC. The GG genotype in rs1229984 was significantly associated with a younger age of onset than other genotypes (p = 0.001 and <0.001, respectively) in OPSCC patients who consumed alcohol.ConclusionADH1B was an important genetic locus that significantly correlated with the development of OPSCCs and patient survival.
Real‑world survival outcome comparing abiraterone acetate plus prednisone and enzalutamide for nonmetastatic castration‐resistant prostate cancer
Authors: Tsujino Takuya , Tokushige Satoshi , Komura Kazumasa , Fukuokaya Wataru , Adachi Takahiro , Hirasawa Yosuke , Hashimoto Takeshi , Yoshizawa Atsuhiko , Saruta Masanobu , Ohno Takaya , Nakamori Keita , Maenosono Ryoichi , Nishimura Kazuki , Yamazaki Shogo , Uchimoto Taizo , Yanagisawa Takafumi , Mori Keiichiro , Urabe Fumihiko , Tsuzuki Shunsuke , Iwatani Kosuke , Yamamoto Shutaro , Takahara Kiyoshi , Inamoto Teruo , Kimura Takahiro , Ohno Yoshio , Shiroki Ryoichi , Azuma Haruhito 
Published: September 2023

AbstractBackgroundThere is little evidence of abiraterone acetate (AA) plus prednisone for patients with non‐metastatic castration‐resistant prostate cancer (nmCRPC). In this study, we conducted a comparative analysis of real‐world survival outcomes between AA plus prednisone and enzalutamide (Enz) in patients with nmCRPC, utilizing our consortium dataset.Materials and MethodsThe clinical records of 133 nmCRPC patients treated with first‐line Enz or AA plus prednisone were analyzed. The primary endpoints of the study were overall survival (OS) and cancer‐specific survival (CSS). Cumulative incidence function (CIF) using Fine and Gray models was also utilized to assess non‐cancer‐caused death considering the competing risk of cancer‐caused death.ResultsDuring a median follow‐up of 36 months, 34 patients (25.6%) had deceased, with a median OS of 99 months in the entire cohort. There were no significant differences in comorbidities between the Enz and AA groups. Time to PSA progression (TTPP: HR 0.81, 95% CI 0.51–1.30, P = 0.375) and CSS (HR 1.32, 95% CI 0.55–3.44, P = 0.5141) were comparable between the two groups. However, intriguingly, there was a trend towards shorter OS in patients treated with AA plus prednisone compared to Enz (HR 0.57, 95% CI 0.29–1.12, P = 0.0978, median of 99 and 69 months in Enz and AA groups, respectively). CIF analysis revealed that nmCRPC patients treated with AA plus prednisone were more likely to result in non‐cancer‐caused death than those treated with Enz (HR 5.22, 95% CI 1.88–14.50, P = 0.0014).ConclusionsOur real‐world survival analysis suggests that while AA plus prednisone may demonstrate comparable treatment efficacy to Enz in the context of nmCRPC, there may be an increased risk of non‐cancer‐caused death. Physicians should take into consideration this information when making treatment decisions for patients with nmCRPC.
Stimuli‐Responsive and Multifunctional Nanogels in Drug Delivery
Authors: Ashwani P. V. , Gopika G. , Arun Krishna K. V. , Jose Josena , John Franklin , George Jinu 
Published: September 2023

AbstractNanogels represent promising drug delivery systems in the biomedical field, designed to overcome challenges associated with standard treatment approaches. Stimuli‐responsive nanogels, often referred to as intelligent materials, have garnered significant attention for their potential to enhance control over properties such as drug release and targeting. Furthermore, researchers have recently explored the application of nanogels in diverse sectors beyond biomedicine including sensing materials, catalysts, or adsorbents for environmental applications. However, to fully harness their potential as practical delivery systems, further research is required to better understand their pharmacokinetic behaviour, interactions between nanogels and bio distributions, as well as toxicities. One promising future application of stimuli‐responsive multifunctional nanogels is their use as delivery agents in cancer treatment, offering an alternative to overcome the challenges with conventional approaches. This review discusses various synthetic methods employed in developing nanogels as efficient carriers for drug delivery in cancer treatment. The investigations explore, the key aspects of nanogels, including their multifunctionality and stimuli‐responsive properties, as well as associated toxicity concerns. The discussions presented herein aim to provide the readers a comprehensive understanding of the potential of nanogels as smart drug delivery systems in the context of cancer therapy.
State estimation for one‐dimensional agro‐hydrological processes with model mismatch
Authors: Liu Zhuangyu , Liu Jinfeng , Zhao Shunyi , Luan Xiaoli , Liu Fei 
Published: September 2023

AbstractThe importance of accurate soil moisture data for the development of modern closed‐loop irrigation systems cannot be overstated. Due to the diversity of soil, it is difficult to obtain an accurate model for the agro‐hydrological system. In this study, soil moisture estimation in one‐dimensional (1D) agro‐hydrological systems with model mismatch is the focus. To address the problem of model mismatch, a nonlinear state‐space model derived from the Richards equation is utilized, along with additive unknown inputs. The determination of the number of sensors required is achieved through sensitivity analysis and the orthogonalization projection method. To estimate states and unknown inputs in real‐time, a recursive expectation maximization (EM) algorithm derived from the conventional EM algorithm is employed. During the E‐step, the extended Kalman filter (EKF) is used to compute states and covariance in the recursive Q‐function, while in the M‐step, unknown inputs are updated by locally maximizing the recursive Q‐function. The estimation performance is evaluated using comprehensive simulations. Through this method, accurate soil moisture estimation can be obtained, even in the presence of model mismatch.
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
Authors: Ropponen Henni‐Karoliina , Diamanti Eleonora , Johannsen Sandra , Illarionov Boris , Hamid Rawia , Jaki Miriam , Sass Peter , Fischer Markus , Haupenthal Jörg , Hirsch Anna K. H. 
Published: September 2023

AbstractDiscovery of novel antibiotics needs multidisciplinary approaches to gain target enzyme and bacterial activities while aiming for selectivity over mammalian cells. Here, we report a multiparameter optimisation of a fragment‐like hit that was identified through a structure‐based virtual‐screening campaign on Escherichia coli IspE crystal structure. Subsequent medicinal‐chemistry design resulted in a novel class of E. coli IspE inhibitors, exhibiting activity also against the more pathogenic bacteria Pseudomonas aeruginosa and Acinetobacter baumannii. While cytotoxicity remains a challenge for the series, it provides new insights on the molecular properties for balancing enzymatic target and bacterial activities simultaneously as well as new starting points for the development of IspE inhibitors with a predicted new mode of action.
Ionic‐Liquid‐Based Nanofluids and Their Heat‐Transfer Applications: A Comprehensive Review
Authors: Lingala Syam Sundar 
Published: September 2023

AbstractDue to the improved thermophysical characteristics of ionic liquids (ILs), such as their strong ionic conductivity, negligible vapor pressure, and thermal stability at high temperatures, they are being looked at viable contender for future heat transfer fluids. Additionally, the dispersing nanoparticles can further improve the thermophysical characteristics and thermal performance of ionic liquids, which is one of the emerging research interests to increase the heat transfer rates of the thermal devices. The latest investigations about the utilization of ionic liquid nanofluids as a heat transfer fluid is summarized in this work. These summaries are broken down into three types: (a) the thermophysical parameters including thermal conductivity, viscosity, density, and specific heat of ionic liquids (base fluids), (b) the thermophysical properties like thermal conductivity, viscosity, density, and viscosity of ionic liquids based nanofluids (IL nanofluids), and (iii) utilization of IL nanofluids as a heat transfer fluid in the thermal devices. The techniques for measuring the thermophysical characteristics and the synthesis of IL nanofluids are also covered. The suggestions for potential future research directions for IL nanofluids are summarized.