bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regio‐ and Stereoselective Hydroelementation of SF5‐Alkynes and Further Functionalizations.
Authors: Popek Lucas , Cabrera‐Trujillo Jorge Juan , Debrauwer Vincent , Blanchard Nicolas , Miqueu Karinne , Bizet Vincent 
Published: March 2023

AbstractHerein is described a fully regio‐ and stereoselective hydroelementation reaction of SF5‐alkynes with N, O and S‐nucleophiles and further functionalization of the corresponding Z‐(hetero)vinyl‐SF5 intermediates, a suitable platform to access α‐SF5 ketones and esters, β‐SF5 amines and alcohols under mild reaction conditions. Experimental and computational comparative studies between SF5‐ and CF3‐alkynes have been performed to highlight and explain the difference of reactivity and selectivity observed between these two fluorinated motifs.
Come, tell me how you live: Habitat suitability analysis for Ostrea edulis restoration
Authors: Pogoda Bernadette , Hausen Tanja , Rothe Marko , Bakker Felix , Hauser Sarah , Colsoul Bérenger , Dureuil Manuel , Krause Jochen , Heinicke Kathrin , Pusch Christian , Eisenbarth Simone , Kreutle Axel , Peter Corina , Pesch Roland 
Published: March 2023

Abstract

Against the background of the UN decade on ecosystem restoration and the new EU Biodiversity Strategy for 2030, and in the context of marine spatial planning and complex maritime user conflicts, reliable information on habitat suitability for large‐scale restoration is an important prerequisite for implementing conservation management and for supporting successful, sustainable, and ecologically efficient restoration measures.
In this study, habitat suitability was assessed using multicriteria decision analysis (MCDA) for the restoration of the European oyster, Ostrea edulis, in marine protected areas (MPAs) of the German Bight in the North Sea: Borkum Reef Ground (Borkum Riffgrund, BRG) and Sylt Outer Reef – Eastern German Bight (Sylter Außenriff, SAR).
Based on site selection criteria, exclusion and suitability factors for the MCDA were defined. Results were integrated with the available geodata to produce habitat suitability maps for oyster restoration in the area of interest.
Suitable as well as unsuitable habitats have been successfully identified for both MPAs: several hundred square kilometres (≥97.2% of BRG) or several thousand square kilometres (≥74.5% of SAR) were classified as ecologically and logistically suitable for oyster restoration measures in the respective MPAs. As oyster restoration is significantly limited by human activities (e.g. bottom trawl fisheries), the management of fisheries is an important prerequisite for successful oyster restoration in both MPAs. Results show that designated fishery management measures will increase the possibilities for oyster restoration.
In BRG, our results correspond to the known historical distribution. In SAR, our results significantly exceed the historically known distribution. The habitat suitability analysis will facilitate decision‐making regarding ocean use, and will reduce restoration costs through targeted management activities in areas of high suitability and expand species recovery by improving the survival of reintroduced individuals.
The habitat suitability analysis procedure is easily adaptable for application to other areas, other species, or other habitat restoration projects, or to other conservation management settings. The software applied is open source and the suitability calculation is described in detail to inform wider applications.
Materialeffiziente hybride Tragstrukturen – Hochbauprojekt BSCW München
Authors: Pürgstaller Andreas , Taras Andreas , Bergmeister Konrad 
Published: March 2023

AbstractDer Neubau der Berufsschulen für Farben und Gestaltung in München (BSCW) erforderte eine Vielzahl von Lösungsansätzen, welche ihn von Out‐of‐the‐box‐Hochbauprojekten unterscheiden. Der Beitrag gibt Einblicke in die Tragwerksfindung, numerische Modellbildung, wichtige Meilensteine der Baustelle sowie Überlegungen zu Ressourceneffizienz und zirkulärem Bauen mit Verbundkonstruktionen. Hybride Tragstrukturen des Stahl‐, Beton‐ und Verbundbaus können einen wichtigen Beitrag zur Steigerung der Ressourceneffizienz leisten, wenn die Baustoffe Beton und Stahl funktionsgerecht und effizient ausgenutzt werden. Das weitgespannte und integrale Tragwerk mit den markanten sichtbaren Stahl‐Fachwerkträgern als Lastabfangebene im Erdgeschoss kombiniert die Vorteile der Just‐in‐time‐Montage und hohen Vorfertigungsrate mit stark reduziertem Konstruktionseigengewicht. Der numerischen Modellbildung, Lastpfadfindung und konstruktiven Durchbildung kommen entscheidende Bedeutung zu. Tragwerksfindung, Modellbildung und Ressourceneffizienz als zentrale Aufgaben erfordern Kreativität und Mut, neue, ungewohnte Wege aufzuzeigen. Den Tragwerksplanern kommt hierbei eine entscheidende Rolle zu.
A neutral comparison of statistical methods for analyzing longitudinally measured ordinal outcomes in rare diseases
Authors: Geroldinger Martin , Verbeeck Johan , Thiel Konstantin E. , Molenberghs Geert , Bathke Arne C. , Laimer Martin , Zimmermann Georg 
Published: March 2023

AbstractOrdinal data in a repeated measures design of a crossover study for rare diseases usually do not allow for the use of standard parametric methods, and hence, nonparametric methods should be considered instead. However, only limited simulation studies in settings with small sample sizes exist. Therefore, starting from an Epidermolysis Bullosa simplex trial with the above‐mentioned design, a rank‐based approach using the R package nparLD and different generalized pairwise comparisons (GPC) methods were compared impartially in a simulation study. The results revealed that there was not one single best method for this particular design, because a trade‐off exists between achieving high power, accounting for period effects, and for missing data. Specifically, nparLD as well as the unmatched GPC approaches do not address crossover aspects, and the univariate GPC variants partly ignore the longitudinal information. The matched GPC approaches, on the other hand, take the crossover effect into account in the sense of incorporating the within‐subject association. Overall, the prioritized unmatched GPC method achieved the highest power in the simulation scenarios, although this may be due to the specified prioritization. The rank‐based approach yielded good power even at a sample size of , whereas the matched GPC method could not control the type I error.
Fibrin gel enhanced trilayer structure in cell‐cultured constructs
Authors: Snyder Yuriy , Jana Soumen 
Published: March 2023

AbstractEfficient cell seeding and subsequent support from a substrate ensure optimal cell growth and neotissue development during tissue engineering, including heart valve tissue engineering. Fibrin gel as a cell carrier may provide high cell seeding efficiency and adhesion property, improved cellular interaction, and structural support to enhance cellular growth in trilayer polycaprolactone (PCL) substrates that mimic the structure of native heart valve leaflets. This cell carrier gel coupled with a trilayer PCL substrate may enable the production of native‐like cell‐cultured leaflet constructs suitable for heart valve tissue engineering. In this study, we seeded valvular interstitial cells onto trilayer PCL substrates with fibrin gel as a cell carrier and cultured them for 1 month in vitro to determine if this gel can improve cell proliferation and production of extracellular matrix within the trilayer cell‐cultured constructs. We observed that the fibrin gel enhanced cellular proliferation, their vimentin expression, and collagen and glycosaminoglycan production, leading to improved structure and mechanical properties of the developing PCL cell‐cultured constructs. Fibrin gel as a cell carrier significantly improved the orientations of the cells and their produced tissue materials within trilayer PCL substrates that mimic the structure of native heart valve leaflets and, thus, may be highly beneficial for developing functional tissue‐engineered leaflet constructs.
Firm's biodiversity initiatives disclosure and board gender diversity: A multi‐country analysis of corporations operating in Europe
Authors: Issa Ayman , Zaid Mohammad A. A. 
Published: March 2023

AbstractEnvironmental practices, in particular biodiversity protection, are crucial for a business to maintain its market valuation and social license. Grounded in resource dependency theory and upper echelon theory, we test the link between board gender diversity and firm's biodiversity initiatives disclosure. Also, we investigate potential moderating variables such as eco‐innovation, resource consumption reduction, and firm's corporate social responsibility (CSR) awards that could strengthen the link between board gender diversity and corporate biodiversity initiatives disclosure. To empirically test our study's framework, we rely on a sample of non‐financial firms operating in 13 European countries between 2002 and 2021. Our estimation results show that women's presence on boards is positively associated with better disclosure of biodiversity conservation initiatives of a firm. Also, our study suggests that firm's eco‐innovation, resource usage, and CSR awards are important and moderate the board gender diversity and biodiversity conservation disclosure nexus. Our results hold to a battery of sensitivity analyses.
Widely Targeted Metabolomics Analysis ofDendrobium officinaleat Different Altitudes
Authors: Jia Xiaohuan , Wu Faming , Lu Anjing , Tan Daopeng , Zhang Qianru , He Yuqi , Qin Lin 
Published: March 2023

AbstractIn order to investigate the differences in the chemical composition ofDendrobium officinaleat different altitudes, we collectedDendrobium officinalefrom different altitudes in Guizhou Province, China, and firstly determined its polysaccharide content by using a sulfuric acid‐phenol color development method with reference to the Chinese Pharmacopoeia, and further determined its metabolites by using widely targeted metabolomics, and explored the differences in the chemical composition ofDendrobium officinaleat different altitudes using multivariate statistical analysis. We found that the polysaccharide content was higher in plants growing at 1122 m, a total of 902 secondary metabolites were detected by wildly targeted metabolomics, and amino acids and their derivatives were more highly expressed at 1122 m, while other metabolites were more highly expressed at 835 m. Furthermore, we found that the phenolic acid compound nerugein was only present inplantsat 835 m, and two lipid compounds, namely Lyso PE 20 : 4 and its isomer, were only present at 1122 m. Taken together, these results may provide a basis for the selection and clinical application ofD. officinalecultivated at different altitudes.
Relationship Between Phenolic Content Determined by LC/MS/MS and Antioxidant Capacity and Enzyme Inhibition of Cyclotrichium niveum L.
Authors: Güzel Abdussamat 
Published: March 2023

AbstractCyclotrichium niveum (Boiss.) Manden & Scheng belonging to the Lamiaceae family, which is an endemic species in the eastern Anatolian region of Turkey, has an important place in terms of ethno‐botany. The phytochemical composition of the plant, inhibition of acetylcholinesterase (AChE) (which hydrolyzes the neurotransmitter acetylcholine), inhibition of paraoxonase for antiatherosclerotic activity (hPON 1) (which detoxifies organophosphates), and antioxidant capacity were all investigated in this study. Phytochemical content was determined by LC/MS/MS, and enzyme inhibition and antioxidant capacity studies were determined by spectrophotometer. Antioxidant capacity of C. niveum extracts (methanol, hexane, and water) was determined by applying ABTS⋅+, DPPH⋅, FRAP, and CUPRAC methods. Both the water and the methanol extracts of the C. niveum exhibited significant inhibition on the AChE (IC50 value for methanol and water extract 0.114±0.14 mg/mL (R2:0.997) and 0.178±0.12 mg/mL (R2: 0.994), respectively). In contrast, the methanol and water extracts of the C. niveum did not exhibit the inhibition effect on hPON 1. The highest activity for ABTS⋅+ was 66.53 % in the water extract, and DPPH⋅ was 55.03 % in the methanol extract. In the metal‐reducing power assay, the absorbance was 0.168±0.04 for FRAP water extract and 0.621±0.01 for CUPRAC methanol extract. According to LC/MS/MS analyses, hydroxybenzoic acid, salicylic acid, syringic acid, acetohydroxamic acid and luteolin determined in the plant extract. As a consequence, C. niveum which has antioxidant, anti‐atherogenic and anti‐neurodegenerative properties has the potential to be used as a natural medication instead of synthetic drugs used in Alzheimer's patients.
Syntheses and Antibacterial Evaluation of New Penicillium Metabolites Gregatins G and Thiocarboxylics C
Authors: Gillsch Franziska , Mbui Fredrick , Bilitewski Ursula , Schobert Rainer 
Published: March 2023

AbstractTwo pairs of side‐chain epimeric 3‐methoxycarbonyl‐dihydrofuran‐4‐ones with structures purported for thiocarboxylics C1/2 and gregatins G1/2, isolated from Penicillium sp. Sb62, were synthesised for the first time in five steps and 17–25 % yield. Key steps were a Suzuki cross‐coupling, a Yamaguchi esterification, and a base‐induced Knoevenagel‐type condensation. The optimum protecting group for the 10‐OH group in the dienyl side‐chain, orthogonal to necessary protecting groups on O‐10 of the furanone, was found to be t‐butyldiphenylsilyl (TBDPS). The specific rotations of our synthetic products deviated markedly from those reported for the natural isolates. In contrast to the isolates, the synthetic products were not active against Escherichia coli and Staphylococcus aureus bacteria.
Up to snuff (box): Coalescing advances in dorsal radial arterial access
Authors: Soofi Muhammad , Gilchrist Ian C. 
Published: March 2023

Key Points
Publications concerning the dorsal radial approach have proliferated providing an opportunity to evaluate the present state of knowledge with meta‐analysis.
Advantage to the dorsal radial compared to conventional radial access include less radial artery occlusion, quicker hemostasis time and less bleeding.
Disadvantages to dorsal radial continue to be an increased access time and greater risk of cross‐over, both characteristics that may be attenuated by experience.
Combined use of peripheral nerve stimulation and dorsal root ganglion stimulation for refractory complex regional pain syndrome type I to avoid amputation: A case report
Authors: Aman Mansoor M. , Ibrahim Yussr M. , Buluk Figueira Merve , Werhand Jessica M. 
Published: March 2023

AbstractWe describe a case of left foot and ankle complex regional pain syndrome type 1 that necessitated a novel combination of a functioning dorsal root ganglion stimulation and peripheral nerve stimulation. This approach optimized pain relief, functional improvement, and avoided amputation.
Reconstruction of persistent oronasal communication using an anteriorly based tongue flap following failed cleft palate repair—Report of two cases
Authors: Guthua Symon , Sarna Krishan , Kamau Martin , Ng'ang'a Peter M. 
Published: March 2023

AbstractThe tongue flap is a suitable alternative to local mucoperiosteal flaps in closure of wide, persistent oronasal communications, surrounded by scarred and fibrotic tissue as a result of previously attempted palatoplasty. Herein, we report two cases with large recurrent oronasal communication closed using the anteriorly based dorsal tongue flap.
Mid‐lateral approach for revascularization of an amputated second toe: A case report
Authors: Nishimura Ken , Fukasawa Katsuyasu , Sugawara Runa , Kobayashi Koichi 
Published: March 2023

AbstractThe plantar or dorsal approach has been previously reported for the replantation or revascularization of a completely or incompletely amputated lesser toe. However, no reports exist describing an alternative approach for the replantation or revascularization of an amputated lesser toe, either complete or incomplete. We encountered a rare case of revascularization of an incompletely amputated second toe using a mid‐lateral approach. The purpose of this case report was to describe the mid‐lateral approach, which is novel in its nature for the replantation or revascularization of a completely or incompletely amputated lesser toe. A 43‐year‐old male was involved in a motor vehicle accident and had incomplete crush amputation of a second toe at the base of the nail, along with open dislocation of the distal interphalangeal (DIP) joint in the third toe. We performed artery‐only revascularization of the second toe using a mid‐lateral approach, with the patient in the supine position with his hip in flexion and external rotation. The postoperative course was uneventful, and the second toe was deemed viable. The Japanese Society for Surgery of the Foot (JSSF) standard rating system of the lesser toe was rated 90 and the Self‐Administered Foot Evaluation Questionnaire (SAFE‐Q) scored 100 in all the mentioned categories. The mid‐lateral approach could be an option for the replantation or revascularization of an amputated lesser toe distal to the proximal interphalangeal (PIP) joint.
Stability of a Silica‐Supported Second Generation Hoveyda‐Grubbs Catalyst Under Atmospheric Conditions: Experimental and Computational Studies
Authors: Nieres Pablo D. , Vaillard Victoria A. , Zelín Juan , Neuman Nicolás I. , Trasarti Andrés F. , Apesteguía Carlos R. , Vaillard Santiago E. 
Published: March 2023

AbstractSecond generation Hoveyda‐Grubbs (HG2) is a reliable and extremely useful catalyst for the synthesis of olefins. Recent studies show that supported HG2 catalyst is particularly well suited for the self‐metathesis reaction of unsaturated fatty acid methyl esters, such as methyl oleate (MO), among other applications. Within the various supports that have been studied, silica gel appears as one of the most promising for large scale application of heterogeneous HG2. In this work we found that although the catalyst supported on silica gel retains its activity when stored under strictly controlled conditions (vacuum, 253 K), the activity deeply decreases when the supported complex is stored under atmospheric conditions at 298 K, compromising the stability and applicability of the heterogeneous catalyst. We carried out a detailed experimental and spectroscopic study of the deactivation process of the supported catalyst, which, aided by electronic structure calculations, allowed us to throw some light onto the catalyst decomposition process.
Highly Luminescent Blue Emitter with Balanced Hybridized Locally and Charge‐Transfer Excited‐States Emission
Authors: Wiefermann Julia , Kaminski Jeremy M. , Pankert Elisabeth , Hertel Dirk , Meerholz Klaus , Marian Christel M. , Müller Thomas J. J. 
Published: March 2023

AbstractThe Front Cover image is provided by Julia Wiefermann, Institute of Organic Chemistry and Macromolecular Chemistry (HHU, Düsseldorf, Germany). The image shows the highly blue luminescent emitter 4’’‐(diphenylamino)‐2’’‐methyl‐[1,1’:4’,1’’‐terphenyl]‐4‐carbonitrile which exhibits balanced hybridized local and charge‐transfer (HLCT) excited state emission. This compound was successfully employed in an OLED device. Read the full text of the Research Article at 10.1002/cptc.202200265.
Comparison of flowcytometry‐based scoring system for the diagnosis of early T precursor‐acute lymphoblastic leukemia
Authors: Marballi Basavaraju Deepak , Mishra Shruti , Chhabra Gaurav , Chougule Sudarshan 
Published: March 2023

AbstractBackgroundEarly T cell precursor‐acute lymphoblastic leukemia (ETP‐ALL) is a hematolymphoid malignancy where the blasts demonstrate T cell differentiation markers along with stem cell and myeloid antigen expression. The differential diagnosis of ETP‐ALL from non‐ETP ALL and mixed phenotype acute leukemia is often challenging due to its overlapping immunophenotypic picture with co‐expression of myeloid antigens. In this study, we endeavored to describe the immune‐phenotype profile of ETP‐ALL in our patients and compared the utility of four different scoring systems for better discrimination of these entities.MethodsThis retrospective analysis included 31 ETP‐ALL out of 860 acute leukemia cases consecutively diagnosed at the two tertiary care centers. Flowcytometry‐based immunophenotype was reviewed for all the cases, and the utility of four flow‐based objective scorings was assessed for the diagnosis of ETP‐ALL. Receiver operating curves were drawn to compare the different flow‐based scoring systems.ResultsThe prevalence of ETP‐ALL was 40% (n = 31/77 T‐ALL) in our study group, comprised mainly of adults with a median age of 20 years. The five‐marker scoring system had the maximum area under the curve, followed by the seven‐marker scoring system. A cut‐off of ≥2.5 was more specific (sensitivity: 91%; specificity: 100%), while a score of ≥1.5 was more sensitive but slightly less specific (sensitivity: 94%, specificity: 96%).ConclusionThe WHO criteria for the diagnosis of ETP‐ALL should be followed across all laboratories to avoid confusion and for better treatment stratification. Flow‐based scoring systems can be objectively employed for better detection of cases.
Factors associated with fragility fractures in type 2 diabetes: An analysis of the randomised controlled Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Authors: Sheu Angela , O’Connell Rachel L. , Jenkins Alicia J. , Tran Thach , Drury Paul L. , Sullivan David R. , Li LiPing , Colman Peter , O’Brien Richard , Kesäniemi Y. Antero , Center Jacqueline R. , White Christopher P. , Keech Anthony C. 
Published: March 2023

AbstractAimsFracture risk is elevated in some type 2 diabetes patients. Bone fragility may be associated with more clinically severe type 2 diabetes, although prospective studies are lacking. It is unknown which diabetes‐related characteristics are independently associated with fracture risk. In this post‐hoc analysis of fracture data from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial (ISRCTN#64783481), we hypothesised that diabetic microvascular complications are associated with bone fragility.Materials and MethodsThe FIELD trial randomly assigned 9795 type 2 diabetes participants (aged 50–75 years) to receive oral co‐micronised fenofibrate 200 mg (n = 4895) or placebo (n = 4900) daily for a median of 5 years. We used Cox proportional hazards models to identify baseline sex‐specific diabetes‐related parameters independently associated with incident fractures.ResultsOver 49,470 person‐years, 137/6138 men experienced 141 fractures and 143/3657 women experienced 145 fractures; incidence rates for the first fracture of 4∙4 (95% CI 3∙8–5∙2) and 7∙7 per 1000 person‐years (95% CI 6∙5–9∙1), respectively. Fenofibrate had no effect on fracture outcomes. In men, baseline macrovascular disease (HR 1∙52, 95% CI 1∙05–2∙21, p = 0∙03), insulin use (HR 1∙62, HR 1∙03–2∙55, p = 0∙03), and HDL‐cholesterol (HR 2∙20, 95% CI 1∙11–4∙36, p = 0∙02) were independently associated with fracture. In women, independent risk factors included baseline peripheral neuropathy (HR 2∙04, 95% CI 1∙16–3∙59, p = 0∙01) and insulin use (HR 1∙55, 95% CI 1∙02–2∙33, p = 0∙04).ConclusionsInsulin use and sex‐specific complications (in men, macrovascular disease; in women, neuropathy) are independently associated with fragility fractures in adults with type 2 diabetes.