bluuebunny/crossref_metadata_2025_split huggingface dataset:
Niraparib enhances radiosensitivity in glioblastoma with redistribution of DDX21
Authors: Luo Jia , Xiao He , Li Yanlan , Chen Qian , Wang Wanneng , Geng Mingying 
Published: February 2023

Abstract
Objective
To explore the feasibility and mechanism of PARP inhibitor niraparib as a radiosensitizer for Glioblastoma (GBM).
Methods
Bioinformatics analysis was used to reveal the mechanism of PARP inhibitor in glioma and its correlation with radiotherapy. CCK8 determined the optimal concentration and time of Niraparib in GBM cell lines (A172, U251 and U87). Clonogenic assay was used to detect the radiosensitivity of niraparib in GBM cells. The radiosensitization mechanism of niraparib in GBM cells was studied by flow cytometry, western blot, immunofluorescence and CCK8.
Results
Pathways relevant to ribosome biosynthesis and functions such as eukaryotic translation initiation, rRNA processing was found to be responsible for cytotoxicity of niraparib in 519 tumor cell lines. Moreover, mRNA expression of PARP1/2, genes participated in ribosome biosynthesis and homologous recombination (HR) were all significantly negatively associated with SF2 in 44 NCI-60 cell lines. The IC50 of niraparib in A172 and U87 cell lines were 10.77 ± 3.31 and 32.37 ± 2.84 uM respectively. The DEF37 was established as 1.99 at 348 nM, 2.17 at 1044 nM for A172 cell line and 1.10 at 1056 nM, 1.44 at 3169 nM for U87 cell line, respectively. The treatment of 1056nM niraparib combination with radiation (4Gy) resulted in significant increase in fraction of G2 phase in A172 and U87 cells. The protein expression of DDX21 was only slightly decreased in treated with irradiation alone or niraparib combined with irradiation. Niraparib combined with irradiation could promote the redistribution of DDX21 from the nucleolus to the nucleoplasm in U87 cells. Knockdown of DDX21 significantly reduced proliferation in U87 cells. Niraparib combined with radiotherapy further decreased clonogenic number in U87 cells compared with those treated with niraparib alone or irradiation alone, likewise the U87 cells after knockdown of DDX21. Interestingly, knockdown of DDX21 resulted in significant increasing in clonogenic number of U87 cells.
Conclusion
Niraparib affected ribosome biosynthesis via redistribution of DDX21 from the nucleolus to the nucleoplasm, caused G2/M phase arrest, thus increased the radiosensitivity of U87 cells. Niraparib may be a good radiosensitizer for GBM.
Interval-valued intuitionistic fuzzy symmetric point criterion-based MULTIMOORA method for sustainable recycling partner selection in SMEs
Authors: Rani Pratibha , Mishra Arunodaya Raj , Pamucar Dragan , Ali Jabil , Hezam Ibrahim M. 
Published: February 2023

Abstract
The need and strategy of eco-economy encourage enterprises to reach sustainability by employing sustainable supply chain management. Contrary to the numerous literatures focusing on green design and sustainability practices, this paper presents sustainable recycling partner (SRP) assessment with economic, environmental and social pillars. To propose an integrated framework for SRP selection in small-and-medium enterprises (SMEs), interval-valued intuitionistic fuzzy set (IVIFS)-based model is applied to deal with the vague, uncertain and qualitative information. Inspired by these topics, we propose IVIF-improved Dombi weighted averaging and IVIF-improved Dombi weighted geometric operators to aggregate the decision-making expert’s preferences and discuss some sophisticated characteristics of developed aggregation operators. Further, we establish an integrated weighting model by combining the IVIF-symmetric point of criterion (IVIF-SPC) and IVIF-rank sum (IVIF-RS) tools. Then, the classical multi-attribute multi-objective optimization by ratio analysis (MULTIMOORA) model has been extended using the proposed divergence measure and improved Dombi operators for treating multi-criteria decision analysis problems on IVIFS setting. To explore the effectiveness and practicability of the proposed model, a case study of SRP selection in SMEs is conducted. Further, the sensitivity investigation and comparative discussion are presented to check the stability and robustness of the presented technique.
An automatic classification grading of spinach seedlings water stress based on N-MobileNetXt
Authors: Xu Yanlei , Cong Xue , Zhai Yuting , Gao Zhiyuan , Yu Helong 
Published: February 2023

Abstract
This study proposed an automatic classification method for water stress level of spinach seedlings based on N-MobileNetXt network, solving inefficient water stress classification of spinach seedlings under complex background. Firstly, this study reconstructed the Sandglass Block in MobileNetXt model to effectively increase the model accuracy by adopting up-dimension and down-dimension, and introduced NAM and two-dimensional adaptive average pooling; secondly, this study introduced the group convolution module and a two-dimensional adaptive average pool, which can significantly compress the model parameters and enhance the model robustness separately; finally, this study innovatively proposed the NCAM to enhance the image features obviously. The experimental results showed that the classification accuracy of N-MobileNetXt model for spinach seedlings under the natural environment reached 90.35%, and the number of parameters was decreased by 66% compared with the original MobileNetXt model. While, the model size is only 3.89 MB. Comparing the N-MobileNetXt model with the deep network models proposed in the past five years, the N-MobileNetXt model was superior to other network models in terms of parameters and accuracy of identification. The N-MobileNetXt exhibited a considerable advantage in the rapid and accurate classification of spinach seedlings, and can provide theoretical basis and technical support for automatic irrigation.
The Cycle of Value - A Conservationist Approach to Economics
Authors: Harkiolakis Nicholas 
Published: February 2023

Abstract
A representation of economic activity in the form of a law of conservation of value is presented based on the definition of value as potential to act in an environment. This allows the encapsulation of the term as a conserved quantity throughout transactions. Marginal value and speed of marginal value are defined as derivatives of value and marginal value, respectively. Traditional economic statements are represented here as cycles of value where value is conserved. The role of the government in the economy is also explained through the cycles of value the government is involved in.
Analytical multiconfiguration treatment to one-center many-electron He-isoelectronic ions and Period-II elements with H-like orbitals
Authors: Kapil Bharti , Sharma Shivalika , Aggarwal Priyanka , Hazra Ram Kuntal 
Published: February 2023

Abstract
Employing H-like spin-orbitals (SOs) in electronic structure theory is a long-awaited quantum problemas the analytical integral of Coulomb interaction is very difficult to solve for one-center manyelectron(1c-ne) system. He-isoelectronic ions become a benchmark. Complexity grows fast forPeriod-II s- and p-block elements with increasing number of electrons. Moreover, Hartree-FockSelf-Consistent Field (SCF) and post Hartree-Fock SCF theories generally make use of closed-shell,restricted and unrestricted open-shell single configurations (SCs) but actual electronic bound statesurge for multiconfigurations (MCs). After Born-Oppenheimer (BO) approximation, utilization ofassociated Laguerre polynomial/Whittaker-M function basis sets of H-like SOs for the CoulombGreen′s function among electrons furnishes analytical, terminable, simple and finitely summed integralsin terms of Lauricella functions. MCs complying with so-called ground, singly and multiplyexcited states incurring s- and p-SOs are constructed to capture monopole and dipole factors only.However, we believe that quadrupole and higher order poles can be achieved as a product of angularintegrals using Wigner 3-j symbols and closed forms of radial integrals. We have observed goodagreement among literature and exact ground state energies (GSEs) of He-isoelectronic ions andPeriod-II elements with both their so-called ground electronic configurations as well as MCs. Forcertain elements, we have found satisfactory results for ionization energies (IEs).
Economic tolerance design of the P2 raceway based on the quasi-static model of ball bearings
Authors: Chang Zhou , Hu Lai 
Published: February 2023

Abstract
This study focused on designing the raceway tolerance of high-precision roller bearings. First, a five-degree of freedom quasi-static model was established for angular contact ball bearings. The waviness was included in the manufacturing error, and the radial and axial runouts of the bearing inner ring were calculated. Second, the error homogenization effect of the rolling bearing was studied, and the error homogenization coefficient was defined. The results of the study demonstrated that the bearing rotary accuracy was higher than the raceway error by an order of magnitude. Third, the manufacturing error range of each precision grade of the roller bearing raceway was obtained by investigating errors of the equalization coefficient. Finally, the specific value of the raceway tolerance of P2 roller bearings was obtained.
The effect of luteinizing hormone changes in GnRH antagonist protocol on the outcome of controlled ovarian hyperstimulation and embryo transfer
Authors: Jing-shuang Zhou , Jian-hong Chen , Fei-fei Tang , Jian-ping Ou , Xin Tao , Liu-hong Cai 
Published: February 2023

Abstract
Objective
To investigate the effect of LH level changes on the outcomes of controlled ovarian hyperstimulation (COH) and embryo transfer (ET) in gonadotropin-releasing hormone antagonist (GnRH-ant) protocol. Methods: A total of 721 patients undergoing GnRH-ant protocol COH for the first IVF/ICSI cycles were retrospectively analyzed. COH process were divided into 2 stages, before (stage 1) and after (stage 2) the GnRH-ant initiation, and each with 5 groups basing on LH levels: LH decreased more than 50% (A1, A2), decreased 25%-50% (B1, B2), change less than 25% (C1, C2), increased 25%-50% (D1, D2), and increased more than 50% (E1, E2). Results: There were no significant differences among groups of stage1 regarding COH and ET outcomes. For stage 2, the more obvious the decrease of LH level, the more the number of oocytes retrieved, mature oocytes, fertilized oocytes, embryos cleavaged and the numbers of embryo available (P < 0.05), but without significant differences regarding ET outcomes. We also found the freeze-all rate in Group A2 was higher (P < 0.001). Conclusion: LH level changes before GnRH-ant addition were not related to COH and ET outcomes. LH level changes after the addition of GnRH-ant were related to the outcome of COH, and no significant differences were found relating to ET outcomes.
A cross-sectional analysis between physical activity levels, weight status and empathy-related behaviors in a sample of Tuscany primary school children.
Authors: Masini Alice , Rossi Chiara , Dallolio Laura , Mascherini Gabriele 
Published: February 2023

Abstract

Purpose. The present study aims to investigate the relationship between physical activity (PA) and the development of relational empathy skills in children, taking into account weight status.
Methods. Parents/guardians of primary school children were involved in filling out a questionnaire: the Empathy Questionnaire (EmQue-I13) and children were asked to complete the PAQ-C to investigate the self-reported PA levels. The weight status was assessed using a self-reported Body Mass Index (BMI).
Results. 370 parents or guardians of students who attended primary school (8.53±1.61 yrs) were recruited. The total score was 2.41±0.89 for PAQ-C and 41.17±6.32 for EmQue-I13. The three domains of EmQue-I13 were: Contagion (8.16±2.67), Attention to Others’ Feelings (19.40±2.99) and Prosocial actions (13.62±3.01). Linear regression models showed that a higher PAQ-C score was positively associated with empathy-related total score p <0.001. Weight status, age and gender were not associated with EmQue-I13.
Conclusion. Our results underline the positive association between physical activity and the development of relational empathic skills.
A review of the development and future challenges of case-based reasoning
Authors: Yan Aijun , Cheng Zijun 
Published: February 2023

Abstract
Case-based reasoning (CBR), which is based on the cognitive assumption that similar problems have similar solutions, is an important problem-solving and learning method in the field of artificial intelligence. In this article, the development of CBR is mainly reviewed, and the major challenges of CBR are summarized. The paper is organized into four parts. First, the basic framework and concepts of CBR are introduced. Then, the developed technology and innovative work that were formed in solving problems by CBR are summarized. Moreover, the application fields of CBR are sorted. Finally, according to the idea of deep learning and interpretable artificial intelligence, the main challenges for the future development of CBR are proposed.
Comparison of relevance in patient status index (PSI) and spectral edge frequency (SEF) with end-expiratory sevoflurane concentration (ETSEV) during general anesthesia surgery
Authors: Qin Kai , Li Guanzhu 
Published: February 2023

Abstract
Objective. To investigate the correlation between PSI, SEF and ETSEV in patients undergoing general anesthesia.
Methods. In this study, 26 general anesthesia patients (11 males and 15 females, aged 21-70 years, ASA I-III) underwent lower extremity orthopedic surgery were selected. PSI, SEF, and ETSEV were recorded by Sedline brain function monitor and PHILIPS MP20 monitor, respectively, and the difference between SEF-L and SEF-R ΔSEF was calculated. Spearman correlation analysis was used for the correlation between PSI, SEF and ETSEV, and Bland-Altman was used to analyze the consistency of SEF-L and SEF-R.
Results. Spearman correlation analysis showed that PSI (r=-0.401, P=0.001), SEF-L (r=-0.705, P=0.000), and SEF-R (r=-0.635, P=0.000) were all negatively correlated with ETSEV, and SEF was more strongly correlated with ETSEV compared to PSI. Bland-Altman analysis showed that there were 2 points outside the limits of agreement between SEF-L and SEF-R, and SEF-L remained in agreement with SEF-R.
Conclusion. Under sevoflurane-maintained general anesthesia, SEF was more responsive to intraoperative depth of anesthesia changes in patients, and left and right brain SEF remained consistent.
Management dilemma in Pelvi-Ureteric Junction Obstruction : Is Transit Time the answer?
Authors: Malla Aishwarya , Govindarajan Krishna Kumar , Ponnusamy Madhusudhanan , Sambandan Kumaravel , Naredi Bikash Kumar , Jindal Bibekanand 
Published: February 2023

Abstract
Purpose
Pelvi-ureteric junction obstruction (PUJO) is the leading cause for Hydronephrosis in children. Diuretic renography used in the pre and post operative evaluation of Pyeloplasty may not be reliable in predicting the outcome.
Methods
A prospective study was conducted from October 2018 – November 2020, including all children with unilateral PUJO undergoing Pyeloplasty. Renal Diuretic renography scans done in the pre and post operative periods were assessed for Transit time. The time taken for the isotope to reach the renal pelvis was noted by a single observer as the Transit time, from the dynamic frames of the Diuretic renogram.
Results
Of the 65 children, 74% were boys. The transit time (median) in the preoperative renography was 10minutes, whereas the same was 4minutes 45seconds in the postoperative period, the decrease was statistically significant.
On evaluation of Transit time with ROC (Receiver Operating Characteristics) curve, a cut off of 4minutes and 25 seconds was arrived at, which could identify the delayed drainage reliably.
Conclusion
Improvement in Transit time is a reliable predictor of renal function improvement after Pyeloplasty, comparing favorably in relation to split renal function.
Heat Treatment Enhances the Neuroprotective Effects of Crude Ginseng Saponin by Increasing Minor Ginsenosides
Authors: Ji Yun-Jeong , Kim Hyung Don , Lee Eun Suk , Jang Gwi Yeong , Seong Hyun-A 
Published: February 2023

Abstract
Ginsenoside is the primary active substance of ginseng and has many pharmacological effects, such as anti-cancer, immune- sugar- and lipid metabolism-regulating, and antioxidant effects. It also protects the nervous and cardiovascular systems. This study analyzed the effects of thermal processing on the bioactivities of crude ginseng saponin. Heat treatment increased the contents of minor ginsenosides in crude saponin, such as Rg3, and heat-treated crude ginseng saponin (HGS) had better neuroprotective effects than non-treated crude saponin (NGS). HGS reduced glutamate-induced apoptosis and reactive oxygen species generation in pheochromocytoma 12 (PC12) cells significantly more than NGS. HGS protected PC12 cells against glutamate-induced oxidative stress by upregulating Nrf2-mediated antioxidant signaling and downregulating MAPK-mediated apoptotic signaling. HGS has potential for the prevention and treatment of neurodegenerative disorders, such as Alzheimer's and Parkinson's disease.
Consensus DNA and amino acids sequences of the recombinant panfilovirus glycoprotein specific mAb 4B3B5 and its expression in CHO mammalian cell lines
Authors: Bongcam-Rudloff Erik , Plewczynski Dariusz , Vlachakis Dimitrios , Jovelin Fabien , Weyer Jacqueline , Paweska Janusz T , Wayengera Misaki 
Published: February 2023

Abstract
Background: Monoclonal antibodies (mAbs) are a useful resource towards the detection and treatment of dangerous pathogens. The traditional approach to production of mAbs is, however, cumbersome and time consuming. An alternative option, would be to sequence, sub clone & express the genes encoding the mAbs from within a mammalian cell-line. This paper describes the consensus gene and amino acids sequences a recombinant mAb (4B3B5) targeting a conserved epitope (#1) with all filovirus glycoproteins, and its expression in CHO mammalian cells.
Methods: Mice hybridoma were prepared & cultured on Dulbecco’s modified eagle’s medium (DMEM) Total RNA was extracted using RNA-easy isolation reagent (Vazyme), and reverse transcribed into cDNA using SMARTScribe reverse transcriptase. Antibody fragments of heavy (H) and light (L) chains were amplified by rapid amplification of cDNA ends (RACE) and cloned into standard vectors for screening in 5 colonies. Inserts of matching phenotypic colonies were sequenced by Sanger capillary sequencing and aligned by IMGT analysis of VDJ. Isotyping was done by constant region analysis.
Results: Consensus sequences of the coding DNA of the heavy and light chains of an isotype IgG1/kappa recombinant mice mAb (Genbank accession #s OP966770 and OP966771, respectively) are presented. The biophysical profile of the full expressed recombinant mAb demonstrates a single protein of approximately 142 kda under non reducing conditions and tetramer of duplexes of 23ka and 48kda, respectively. The average area under sec-HPLC curve at a wavelength of 280 nm is 2490.55
Conclusions: This work summarizes the consensus DNA and amino acids sequences of the recombinant panfilovirus glycoprotein specific mAb 4B3B5 and its expression in CHO mammalian cell lines.
Population mortality before and during the COVID-19 epidemic in two Sudanese settings: a key informant study
Authors: AbuKoura Rahaf , Checchi Francesco , Abdalla Omamah , Ibrahim Omnia , Hemeadan Ahmed Tom , Eldirdiri Ahmed Ali Ahmed , Mohamed Direeg Ismail , Ahmed Aljaile , Ahmed Abd Elhameed , Abdelmagid Nada , Pepe Pasquale , Dahab Maysoon 
Published: February 2023

Abstract
Background
Population mortality is an important metric that sums information from different public health risk factors into a single indicator of health. However, the impact of COVID-19 on population mortality in low-income and crisis-affected countries like Sudan remains difficult to measure. Using a community-led approach, we estimated excess mortality during the COVID-19 epidemic in two Sudanese communities.
Methods
Three sets of key informants in two study locations, identified by community-based research teams, were administered a standardised questionnaire to list all known decedents from January 2017 to February 2021. Based on key variables, we linked the records before analysing the data using a capture-recapture statistical technique that models the overlap among lists to estimate the true number of deaths.
Results
We estimated that deaths per day were 5.5 times higher between March 2020 and February 2021 compared to the pre-pandemic period in East Gezira, while in El Obeid City, the rate was 1.6 times higher.
Conclusion
This study suggests that using a community-led capture-recapture methodology to measure excess mortality is a feasible approach in Sudan and similar settings. Deploying similar community-led estimation methodologies should be considered wherever crises and weak health infrastructure prevent an accurate and timely real-time understanding of epidemics' mortality impact in real-time.
Strategi Implementasi Manajemen Mutu Terpadu (MMT) dI SDN SN Kebun Bunga 4 Banjarmasin
Authors: Sari Mini 
Published: February 2023

Penelitian ini bertujuan menganalisis strategi implementasi manajemen mutu terpadu (MMT) yang sudah dijalankan oleh SDN SN Kebun Bangsa 4 Banjarmasin. Metode penelitian yang digunakan adalah pendekatan kualitatif, dengan jenis penelitian deskriptif. Dimana penelitian ini bertujuan untuk menggambarkan data dengan kata atau uraian dan penjelasan secara mendalam. Sumber data primer dalam penelitian ini adalah : (1) Kepala Sekolah, (2) Guru, (3) Orang tua siswa / wali, dan (4) Siswa. Sedangkan data sekunder adalah data yang diperoleh dari atau berasal dari kajian pustaka melalui media cetak maupan online seperti buku, artikel, juklak, karya tulis ilmiah yang mendukung objek penelitian. Dalam penelitian ini teknik pengumpulan data yang digunakan adalah: (1) (pengamatan), (2) teknik wawancara, dan (3) teknik dokumentasi. Analisis data dengan reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa strategi implementasi yang sudah ada dalam pelaksanaan manajemen mutu terpadu sudah baik dengan adanya penciptaan tujuan berupa visi dan misi yang jelas dan terukur, pengembangan dan peningkatan kompetensi pendidik dan tenaga kependidikan secara berkala, strategi pembelajaran inovatif yang selalu ada, serta penerapan konsep pengembangan diri siswa secara intens. Sehingga dapat disimpulkan bahwa apa yang telah diimplementasikan oleh SDN SN Kebun Bunga 4 Banjarmasin sudah sesuai dengan manajemen mutu terpadu.