bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of metabolic activity of lactic acid bacteria and propionibacteria on cheese protein digestibility and fatty acid profile
Authors: Ziarno Małgorzata , Bryś Joanna , Kowalska Ewa , Cichońska Patrycja 
Published: September 2023

AbstractThis study aimed at investigating the influence of different variants of bacterial starter cultures on the metabolism of the bacteria used, cheese protein digestibility, and fatty acid profile. The results revealed that lactic acid bacteria had a significant effect on the proportions of fatty acids in cheeses, with saturated fatty acids being predominant in in all cheese variants. Fatty acid proportions are complex and depend on the type of cheese culture and monoculture used. Additionally, the analysis of fatty acid composition showed variations in the proportion of saturated and unsaturated fatty acids, impacting the values of atherogenic and thrombogenic indices. Notably, the atherogenic index was highest in samples of mature cheeses obtained from a typical mesophilic cheese culture, whereas it was lowest in samples of fresh milk and mature cheeses obtained from a mesophilic cheese culture and monocultures of Lacticaseibacillus casei and Propionibacterium. The study also highlighted the influence of lactobacilli on the content of available free lysine, glycine, and methionine in cheese proteins. Mature cheeses obtained with Propionibacterium and L. casei starter cultures exhibited higher free lysine and glycine content compared with fresh cheeses and those obtained solely with the cheese culture. Additionally, mature cheeses obtained with starter cultures of mesophilic cheese culture, Propionibacterium, and L. casei had the highest free methionine content. Based on these findings, it is evident that the choice of cheese making cultures and monocultures can significantly affect the fatty acid composition and amino acid content of cheese and fresh milk, potentially bearing important health implications.
Interactions between C-steel and blended cement in concrete under radwaste repository conditions at 80 °C
Authors: Fabian Margit , Czompoly Otto , Tolnai Istvan , De Windt Laurent 
Published: September 2023

AbstractDeep geological repository is widely considered as the preferred solution for the final disposal of high-level radioactive waste. Investigation representative of the Hungarian disposal concept was conducted using mock-up diffusion cells to study the chemical changes of S235JR carbon steel canister and CEM II/B concrete of the Public Limited Company for Radioactive Waste Management under anerobic and water saturated conditions at 80 °C. Micro-Raman, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy, fluid and potentiometric analysis were performed over a period of 12 months. The analysis was supported by thermodynamic and reactive transport modeling using the HYTEC code. The findings revealed that a uniform corrosion process occurred, leading to rapid passivation of the C-steel with magnetite as the primary corrosion product. Modeling demonstrated that the increase in temperature to 80 °C and the chemical evolution of the concrete did not significantly affect the corrosion passivation process. Although the formation of Fe-siliceous hydrogarnets is thermodynamically possible at 80 °C, it did not jeopardize magnetite passivation. The results show that the passivation of the containers occurred under the test conditions and this is a promising result for further investigations.
Feasibility of administration of calcitonin gene-related peptide receptor antagonist on attenuation of pain and progression in osteoarthritis
Authors: Nekomoto Akinori , Nakasa Tomoyuki , Ikuta Yasunari , Ding Chenyang , Miyaki Shigeru , Adachi Nobuo 
Published: September 2023

AbstractSuppressing inflammation and abnormal subchondral bone turnover is essential for reducing osteoarthritis (OA) progression and pain relief. This study focused on calcitonin gene-related peptide (CGRP), which is involved in inflammation and bone metabolism, and investigated whether a CGRP receptor antagonist (rimegepant) could suppress OA progression and relieve pain in two OA models. C57BL/6 mice (10-week-old) underwent surgical destabilization of the medial meniscus, and Rimegepant (1.0 mg/kg/100 μL) or phosphate-buffered saline (100 μL) was administered weekly intraperitoneally after OA surgery and evaluated at 4, 8, and 12 weeks. In the senescence-accelerated mice (SAM)-prone 8 (SAMP8), rimegepant was administered weekly before and after subchondral bone sclerosis and sacrificed at 9 and 23 weeks, respectively. Behavioral assessment and immunohistochemical staining (CGRP) of the dorsal root ganglion (DRG) were conducted to assess pain. In DMM mice, synovitis, cartilage degeneration, and osteosclerosis were significantly suppressed in the rimegepant group. In SAMP8, synovitis, cartilage degeneration, and osteosclerosis were significantly suppressed by rimegepant at 9 weeks; however, not at 23 weeks. Behavioral assessment shows the traveled distance and the number of standings in the rimegepant group were significantly longer and higher. In addition, CGRP expression of the DRG was significantly lower in the rimegepant group at 8 and 12 weeks of DMM and 9 weeks of SAMP8 treatment. No adverse effects were observed in either of the mouse models. Inhibition of CGRP signaling has the potential to be a therapeutic target to prevent OA progression and suppress pain through the attenuation of subchondral bone sclerosis and synovitis.
The effect of material defect orientation on rolling contact fatigue of a ball bearing
Authors: Ghazanfari Holagh Akbar , Alizadeh Kaklar Javad 
Published: September 2023

AbstractIn this study, finite element method (FEM) is applied to investigate the effect of material defect orientation on subsurface crack initiation in rolling bearings. First, the history of stress intensity factors (SIFs) of a subsurface cubic material defect is calculated. SIFs calculation is conducted when it is parallel to the rolling surface of a bearing ring ($$\varphi = 0^\circ$$

φ
=

0
∘

) under a ball rolling on the ring. Then, the effect of defect orientation, varying from $$\varphi = 0^\circ$$

φ
=

0
∘

to $$\varphi \; = \;30,\; 45\; {\text{and}} \;60^\circ$$

φ

=

30
,

45

and

60
∘

, on the history of SIFs is investigated. It is deduced that changing the defect orientation results in a threefold increase in the equivalent SIF range compared to parallel orientation.
Outcomes of targeted treatment in immunocompromised patients with asymptomatic or mild COVID-19: a retrospective study
Authors: Lahouati M. , Cazanave C. , Labadie A. , Gohier P. , Guirlé L. , Desclaux A. , Gigan M. , Malvy D. , Pedeboscq S. , Xuereb F. , Duvignaud A. ,   The Bordeaux COVID-19 Treatment Group, Barthod Laure , Bellecave Pantxika , Blanc Jean-Frédéric , Blanchard Elodie , Bonnet Fabrice , Camou Fabrice , Carrer Mathilde , Cazanave Charles , Chermak Faiza , Couzi Lionel , Daste Amaury , Dauchy Frédéric-Antoine , De Ledinghen Victor , Domblides Charlotte , Duffau Pierre , Dutronc Hervé , Duvignaud Alexandre , Faure Maxime , Forcade Edouard , Issa Nahéma , Kaminski Hannah , Hiriart Jean-Baptise , Lahouati Marin , Leitao Julie , Lescure Maëlig , Lazaro Estibaliz , Maachi Isabelle , Neau Didier , Nguyen Duc , Nubret Karine , Pédeboscq Stéphane , Pistone Thierry , Pribat Frédérique , Puges Mathilde , Ruet Aurélie , Tumiotto Camille , Vandenhende Marie-Anne , Wirth Gaétane 
Published: September 2023

AbstractThe aim of this study was to describe the outcomes of targeted COVID-19 treatments in immunocompromised patients with asymptomatic or mild COVID-19 during the period of expansion of the different Omicron subvariants in France. A retrospective monocentric observational study was performed. All immunocompromised patients aged 18 or more, with asymptomatic SARS-CoV-2 infection or mild COVID-19, and who had received a targeted treatment with sotrovimab, tixagevimab/cilgavimab, nirmatrelvir/ritonavir or remdesivir at the Bordeaux University Hospital from 1st January 2022 to 31st December 2022 were eligible. The primary outcomes of interest was defined as a composite of either (i) progression to moderate (WHO-Clinical Progression Scale at 4 or 5) or severe COVID-19 (WHO-CPS ≥ 6), or (ii) the occurrence of COVID-19-related death. The secondary outcomes of interest were the components of the primary outcome. Outcomes were collected until day 30 after targeted treatment administration or at discharge for patients still hospitalised in relation with COVID-19 at day 30. 223 immunocompromised patients received targeted treatment for asymptomatic SARS-CoV-2 infection or mild COVID-19: 114 received sotrovimab, 50 tixagevimab/cilgavimab, 49 nirmatrelvir/ritonavir, and 10 remdesivir. Among 223 treated patients, 10 (4.5%) progressed to moderate or severe disease: three patients (1.3%) progressed to moderate COVID-19 and 7 (3.1%) patients progressed to severe disease. Among them, 4 (1.8%) died of COVID-19. More than 95% of immunocompromised patients with asymptomatic SARS-CoV-2 infection or mild COVID-19 treated by targeted therapies during the Omicron subvariants era did not progress to moderate or severe disease.
Landslide risk evaluation method of open-pit mine based on numerical simulation of large deformation of landslide
Authors: Jia Lan , Wang Jiaqi , Gao Shisong , Fang Linhao , Wang Dong 
Published: September 2023

AbstractIt is of great practical significance to carry out quantitative risk assessment of landslide disaster to protect people’s lives and property safety and maintain the sustainable development of social economy. The delineation of landslide disaster range is the key link of landslide risk evaluation in open-pit mine. This study took the open-pit coal mine coal mine in Block I of Thar coal field in Pakistan as the research background, and constructed a framework for landslide risk evaluation in open-pit mines. Based on the numerical simulation method of large deformation of landslide, the disaster range of landslide in open-pit mine was delineated. The stability of stope slope was analyzed based on rigid body limit equilibrium method. The probability of landslide instability was calculated based on Monte Carlo method. And the comprehensive fuzzy evaluation model was established to calculate the total risk value of landslide. The results showed that: through numerical simulation and empirical formula calculation, the landslide disaster range was accurately delineated, and the comprehensive vulnerability of the disaster bearing body was determined to be medium vulnerability; the annual probability of landslide instability under natural conditions was 0.003, which belongs to moderate risk. The annual probability of landslide instability under rainstorm conditions was 0.024, which was highly dangerous; the annual probability of landslide instability under seismic conditions was 0.018, which was highly dangerous. Under natural conditions, the total risk value of landslide was 114,686.4 rmb, and the annual mortality rate of population was 0.0255 people/year. The total risk value of landslide under rainstorm condition was 11,707,570 rmb, and the annual mortality rate of population was 0.18375 people/year. The total risk value of landslide under earthquake condition was 43,007,400 rmb, and the annual mortality rate of population was 0.135 person/year, which was an unacceptable risk. The economic loss was a small geological disaster risk under natural conditions, and it was a medium-sized geological disaster risk under both rainstorm and earthquake conditions. Therefore, landslide prevention and control and management measures such as slope deformation monitoring were proposed to ensure the safety of personnel and property in open-pit mines.
Mild sleep restriction increases endothelial oxidative stress in female persons
Authors: Shah Riddhi , Shah Vikash Kumar , Emin Memet , Gao Su , Sampogna Rosemary V. , Aggarwal Brooke , Chang Audrey , St-Onge Marie-Pierre , Malik Vikas , Wang Jianlong , Wei Ying , Jelic Sanja 
Published: September 2023

AbstractSleep restriction is associated with increased cardiovascular risk, which is more pronounced in female than male persons. We reported recently first causal evidence that mild, prolonged sleep restriction mimicking “real-life” conditions impairs endothelial function, a key step in the development and progression of cardiovascular disease, in healthy female persons. However, the underlying mechanisms are unclear. In model organisms, sleep restriction increases oxidative stress and upregulates antioxidant response via induction of the antioxidant regulator nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Here, we assessed directly endothelial cell oxidative stress and antioxidant responses in healthy female persons (n = 35) after 6 weeks of mild sleep restriction (1.5 h less than habitual sleep) using randomized crossover design. Sleep restriction markedly increased endothelial oxidative stress without upregulating antioxidant response. Using RNA-seq and a predicted protein–protein interaction database, we identified reduced expression of endothelial Defective in Cullin Neddylation-1 Domain Containing 3 (DCUN1D3), a protein that licenses Nrf2 antioxidant responses, as a mediator of impaired endothelial antioxidant response in sleep restriction. Thus, sleep restriction impairs clearance of endothelial oxidative stress that over time increases cardiovascular risk.Trial Registration: NCT02835261
Unclear tumor border in magnetic resonance imaging as a prognostic factor of squamous cell cervical cancer
Authors: Sato Mamiko , Tamauchi Satoshi , Yoshida Kosuke , Yoshihara Masato , Ikeda Yoshiki , Yoshikawa Nobuhisa , Kajiyama Hiroaki 
Published: September 2023

AbstractMagnetic resonance imaging (MRI) is used for pretreatment staging in cervical cancer. In the present study, we used pretreatment images to categorize operative cases into two groups and evaluated their prognosis. A total of 53 cervical cancer patients with squamous cell carcinoma who underwent radical hysterectomy were included in this study. Based on MRI, the patients were classified into two groups, namely clear and unclear tumor border. For each patient, the following characteristics were evaluated: overall survival; recurrence-free survival; lymph node metastasis; lymphovascular space invasion; and pathological findings, including immunohistochemical analysis of vimentin. The clear and unclear tumor border groups included 40 and 13 patients, respectively. Compared with the clear tumor border group, the unclear tumor border group was associated with higher incidence rates of recurrence (3/40 vs. 3/13, respectively), lymphovascular space invasion (24/40 vs. 13/13, respectively), lymph node metastasis (6/40 vs. 10/13, respectively), and positivity for vimentin (18/40 vs. 10/13, respectively). Despite the absence of significant difference in recurrence-free survival (p = 0.0847), the unclear tumor border group had a significantly poorer overall survival versus the clear tumor border group (p = 0.0062). According to MRI findings, an unclear tumor border in patients with squamous cell cervical cancer is linked to poorer prognosis, lymph node metastasis, and distant recurrence of metastasis.
North Atlantic subpolar gyre provides downstream ocean predictability
Authors: Fan Hongdou , Borchert Leonard F. , Brune Sebastian , Koul Vimal , Baehr Johanna 
Published: September 2023

AbstractSlowly varying large-scale ocean circulation can provide climate predictability on decadal time scales. It has been hypothesized that the North Atlantic subpolar gyre (SPG) exerts substantial influence on climate predictability. However, a clear identification of the downstream impact of SPG variations is still lacking. Using the MPI-ESM-LR1.2 decadal prediction system, we show that along the Atlantic water pathway, a dynamical link to the SPG causes salinity to be considerably better predicted than temperature. By modulating the slow northward ocean propagation, the subsurface memory of SPG variations enables salinity to be skillfully predicted up to 8 years ahead. In contrast, the SPG loses influence on temperature before Atlantic water penetrates into the Nordic Seas, and in turn, limits temperature to be predicted only 2 years ahead. This study identifies the key role of SPG signals in downstream prediction and highlights how SPG signals determine prediction time scales for different quantities, opening the door for investigating potentially associated predictions in the subarctic for the earth system, marine ecosystems in particular.
First-in-human prospective trial of sonobiopsy in high-grade glioma patients using neuronavigation-guided focused ultrasound
Authors: Yuan Jinyun , Xu Lu , Chien Chih-Yen , Yang Yaoheng , Yue Yimei , Fadera Siaka , Stark Andrew H. , Schwetye Katherine E. , Nazeri Arash , Desai Rupen , Athiraman Umeshkumar , Chaudhuri Aadel A. , Chen Hong , Leuthardt Eric C. 
Published: September 2023

AbstractSonobiopsy is an emerging technology that combines focused ultrasound (FUS) with microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive molecular diagnosis of brain diseases. Here, we report the first-in-human prospective trial of sonobiopsy in high-grade glioma patients to evaluate its feasibility and safety in enriching plasma circulating tumor biomarkers. A nimble FUS device integrated with a clinical neuronavigation system was used to perform sonobiopsy following an established clinical workflow for neuronavigation. Analysis of blood samples collected before and after FUS sonication showed that sonobiopsy enriched plasma circulating tumor DNA (ctDNA), including a maximum increase of 1.6-fold for the mononucleosome cell-free DNA (cfDNA) fragments (120–280 bp), 1.9-fold for the patient-specific tumor variant ctDNA level, and 5.6-fold for the TERT mutation ctDNA level. Histological analysis of surgically resected tumors confirmed the safety of the procedure. Transcriptome analysis of sonicated and nonsonicated tumor tissues found that FUS sonication modulated cell physical structure-related genes. Only 2 out of 17,982 total detected genes related to the immune pathways were upregulated. These feasibility and safety data support the continued investigation of sonobiopsy for noninvasive molecular diagnosis of brain diseases.
Efficient diagnosis of IDH-mutant gliomas: 1p/19qNET assesses 1p/19q codeletion status using weakly-supervised learning
Authors: Kim Gi Jeong , Lee Tonghyun , Ahn Sangjeong , Uh Youngjung , Kim Se Hoon 
Published: September 2023

AbstractAccurate identification of molecular alterations in gliomas is crucial for their diagnosis and treatment. Although, fluorescence in situ hybridization (FISH) allows for the observation of diverse and heterogeneous alterations, it is inherently time-consuming and challenging due to the limitations of the molecular method. Here, we report the development of 1p/19qNET, an advanced deep-learning network designed to predict fold change values of 1p and 19q chromosomes and classify isocitrate dehydrogenase (IDH)-mutant gliomas from whole-slide images. We trained 1p/19qNET on next-generation sequencing data from a discovery set (DS) of 288 patients and utilized a weakly-supervised approach with slide-level labels to reduce bias and workload. We then performed validation on an independent validation set (IVS) comprising 385 samples from The Cancer Genome Atlas, a comprehensive cancer genomics resource. 1p/19qNET outperformed traditional FISH, achieving R2 values of 0.589 and 0.547 for the 1p and 19q arms, respectively. As an IDH-mutant glioma classifier, 1p/19qNET attained AUCs of 0.930 and 0.837 in the DS and IVS, respectively. The weakly-supervised nature of 1p/19qNET provides explainable heatmaps for the results. This study demonstrates the successful use of deep learning for precise determination of 1p/19q codeletion status and classification of IDH-mutant gliomas as astrocytoma or oligodendroglioma. 1p/19qNET offers comparable results to FISH and provides informative spatial information. This approach has broader applications in tumor classification.
Deep learning enabled topological design of exceptional points for multi-optical-parameter control
Authors: Fu Peng , Du Shuo , Lan Wenze , Hu Leyong , Wu Yiqing , Li Zhenfei , Huang Xin , Guo Yang , Zhu Weiren , Li Junjie , Liu Baoli , Gu Changzhi 
Published: September 2023

AbstractMetasurfaces are 2D artificial nanostructures that exhibit fascinating optical phenomena and flexible capabilities. Multi-optical-parameter metasurfaces have advantages over single-function or single-dimensional metasurfaces, especially in practical applications like holography, sub-diffraction imaging, and vectorial fields. However, achieving multi-optical-parameter control is challenging due to a lack of design strategy, limited manipulation channels, and signal-to-noise ratio problems. Exceptional points (EPs) possess inherent polarization decoupling properties and allow for amplitude and wavelength modulation, opening up research prospects for multi-optical-parameter electromagnetic field modulation and developing compact integrated devices. Leveraging deep learning, we observe topological charge conservation and utilize the topologically protected optical parameter distribution around scattered EPs. Based on these, we introduce amplitude-phase multiplexing and wavelength division multiplexing devices. Our work allows rapid and precise discovery of EPs topology, offers a powerful tool for digging related physics, and provides a paradigm for multi-optical parametric manipulation with high performance and less crosstalk, which is critical for imaging, encryption, and information storage applications.
Resilience‐oriented expansion planning of multi‐carrier microgrid utilizing bi‐level technique
Authors: Dehshiri Badi Alireza , Amir Vahid , Shariatmadar Seyed Mohammad 
Published: September 2023

AbstractThis paper presents the generation and transmission expansion planning (GTEP) in electricity and gas networks by considering their resilience against floods and earthquakes. These networks supply electricity, heat, and gas consumption energies as a multi‐carrier microgrid. The scheme is expressed in the form of bi‐level optimization, the upper level of which is the minimization of generation and transmission planning cost (total investment cost and expected operating cost) in the mentioned networks constrained to the investment budget and the planning model of the mentioned elements. Lower‐level formulation minimizes the total expected annual operating cost of these networks and the expected outage cost of electricity, heat, and gas consumers in the event of floods and earthquakes. This formulation is bound by the power flow equations of electricity and gas networks, the operation and resilience constraints of the networks, and the limitation on generation capability. In this problem, the expected energy not‐supplied and the outage cost during natural disasters are considered resilience indicators. Next, a single‐level model for the proposed design is extracted from the Karush–Kuhn–Tucker (KKT) method. The basic requirement of this method is the convexity of the lower‐level constraints. For this purpose, first, a linear approximation model is obtained for the lower‐level constraints of the problem. Furthermore, stochastic optimization is adopted to model the uncertainty of load, renewable power, and network equipment availability during floods and earthquakes. Finally, the extracted numerical results confirm the capability of the proposed scheme in improving the operation and resilience of the mentioned networks using optimal generation and transmission planning.