bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of interval type-2 fuzzy logic and type-1 fuzzy logic-based approaches to social networks for spam detection with combined feature capabilities
Authors: Atacak İsmail , Çıtlak Oğuzhan , Doğru İbrahim Alper 
Published: April 2023

Background
Social networks are large platforms that allow their users to interact with each other on the Internet. Today, the widespread use of social networks has made them vulnerable to malicious use through different methods such as fake accounts and spam. As a result, many social network users are exposed to the harmful effects of spam accounts created by malicious people. Although Twitter, one of the most popular social networking platforms, uses spam filters to protect its users from the harmful effects of spam, these filters are insufficient to detect spam accounts that exhibit new methods and behaviours. That’s why on social networking platforms like Twitter, it has become a necessity to use robust and more dynamic methods to detect spam accounts.

Methods
Fuzzy logic (FL) based approaches, as they are the models such that generate results by interpreting the data obtained based on heuristics viewpoint according to past experiences, they can provide robust and dynamic solutions in spam detection, as in many application areas. For this purpose, a data set was created by collecting data on the twitter platform for spam detection. In the study, fuzzy logic-based classification approaches are suggested for spam detection. In the first stage of the proposed method, a data set with extracted attributes was obtained by applying normalization and crowdsourcing approaches to the raw data obtained from Twitter. In the next stage, as a process of the data preprocessing step, six attributes in the binary form in the data set were subjected to a rating-based transformation and combined with the other real-valued attribute to create a database to be used in spam detection. Classification process inputs were obtained by applying the fisher-score method, one of the commonly used filter-based methods, to the data set obtained in the second stage. In the last stage, the data were classified based on FL based approaches according to the obtained inputs. As FL approaches, four different Mamdani and Sugeno fuzzy inference systems based on interval type-1 and Interval Type-2 were used. Finally, in the classification phase, four different machine learning (ML) approaches including support vector machine (SVM), Bayesian point machine (BPM), logistic regression (LR) and average perceptron (Avr Prc) methods were used to test the effectiveness of these approaches in detecting spam.

Results
Experimental results were obtained by applying different FL and ML based approaches on the data set created in the study. As a result of the experiments, the Interval Type-2 Mamdani fuzzy inference system (IT2M-FIS) provided the highest performance with an accuracy of 0.955, a recall of 0.967, an F-score 0.962 and an area under the curve (AUC) of 0.971. However, it has been observed that FL-based spam models have a higher performance than ML-based spam models in terms of metrics including accuracy, recall, F-score and AUC values.
Metabolic shift and the effect of mitochondrial respiration on the osteogenic differentiation of dental pulp stem cells
Authors: Wan Lingyun , Wang Linyan , Cheng Ran , Cheng Li , Hu Tao 
Published: April 2023

Background
Metabolism shifts from glycolysis to mitochondrial oxidative phosphorylation are vital during the differentiation of stem cells. Mitochondria have a direct function in differentiation. However, the metabolic shift and the effect of mitochondria in regulating the osteogenic differentiation of human dental pulp stem cells (hDPSCs) remain unclear.

Methods
Human dental pulp stem cells were collected from five healthy donors. Osteogenic differentiation was induced by osteogenic induction medium. The activities of alkaline phosphatase, hexokinase, pyruvate kinase, and lactate dehydrogenase were analyzed by enzymatic activity kits. The extracellular acidification rate and the mitochondrial oxygen consumption rate were measured. The mRNA levels of COL-1, ALP, TFAM, and NRF1 were analyzed. The protein levels of p-AMPK and AMPK were detected by western blotting.

Results
Glycolysis decreased after a slight increase, while mitochondrial oxidative phosphorylation continued to increase when cells grew in osteogenic induction medium. Therefore, the metabolism of differentiating cells switched to mitochondrial respiration. Next, inhibiting mitochondrial respiration with carbonyl cyanide-chlorophenylhydrazone, a mitochondrial uncoupler inhibited hDPSCs differentiation with less ALP activity and decreased ALP and COL-1 mRNA expression. Furthermore, mitochondrial uncoupling led to AMPK activation. 5-Aminoimidazole-4-carboxamide ribonucleotide, an AMPK activator, simulated the effect of mitochondrial uncoupling by inhibiting osteogenic differentiation, mitochondrial biogenesis, and mitochondrial morphology. Mitochondrial uncoupling and activation of AMPK depressed mitochondrial oxidative phosphorylation and inhibited differentiation, suggesting that they may serve as regulators to halt osteogenic differentiation from impaired mitochondrial oxidative phosphorylation.
Feeding preferences and the effect of temperature on feeding rates of the graceful kelp crab, Pugettia gracilis
Authors: Johnson Katrina H. , Dobkowski Katie A. , Seroy Sasha K. , Fox Shelby , Meenan Natalie 
Published: April 2023

Graceful kelp crabs (Pugettia gracilis) are abundant consumers in shallow subtidal ecosystems of the Salish Sea. These dynamic habitats are currently experiencing multiple changes including invasion by non-native seaweeds and ocean warming. However, little is known about P. gracilis’ foraging ecology, therefore we investigated their feeding preferences between native and invasive food sources, as well as feeding rates at elevated temperatures to better assess their role in changing coastal food webs. To quantify crab feeding preferences, we collected P. gracilis from San Juan Island, WA and conducted no-choice and choice experiments with two food sources: the native kelp, Nereocystis luetkeana, and the invasive seaweed, Sargassum muticum. In no-choice experiments, P. gracilis ate equal amounts of N. luetkeana and S. muticum. However, in choice experiments, P. gracilis preferred N. luetkeana over S. muticum. To test effects of temperature on these feeding rates, we exposed P. gracilis to ambient (11.5 ± 1.3 °C) or elevated (19.5 ± 1.8 °C) temperature treatments and measured consumption of the preferred food type, N. luetkeana. Crabs exposed to elevated temperatures ate significantly more than those in the ambient treatment. Our study demonstrates the diet flexibility of P. gracilis, suggesting they may be able to exploit increasing populations of invasive S. muticum in the Salish Sea. Warming ocean temperatures may also prompt P. gracilis to increase feeding, exacerbating harmful impacts on N. luetkeana, which is already vulnerable to warming and invasive competitors.
Calciphylaxis: A Rare Clinical Presentation in a Patient with End-Stage Renal Disease (ESRD)
Authors: Okikiade Adedeji , Browne-Caesar Twanna , Afolayan-Oloye Olayinka , Agboola Rasheed , Browne Kevin 
Published: April 2023

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), affects small arteries of the skin in patients with end-stage renal failure, dialysis patients, and patients with hypercalcemia. The condition is characterized by the calcification of small blood vessels leading to skin necrosis without inflammation. It is frequently complicated by superimposed infection and bleeding and has a high mortality rate.
The rare condition is yet to be documented on the islands of Saint Vincent and the Grenadines. The authors have, therefore, made efforts to document, educate, and discuss this rare presentation in a 65-year-old local Vincentian male with 30 years history of poorly controlled diabetes mellitus and hypertension who commenced hemodialysis two years prior to the presentation for end-stage chronic renal failure. With the increasing incidence and prevalence of diabetes mellitus, hypertension, and complications of chronic kidney disease, and renal failure, this article is written as a case study with a concise literature review on calciphylaxis to provide continuing medical education and increase the level of awareness among medical students and index of suspicion among healthcare providers.
Participation of Diverse Gender in Negros Occidental in the Production of Goats
Authors: Delmonte Meg Aui O. , Tongol Mae Ann S. , Pillones Chiremy T. , Pardillo Nyle A. 
Published: April 2023

Aims: This study aims to identify the demographic profile of each involved in goat raising and to identify the different practices of each gender involved in goat raising.
Study Design: The study used the descriptive type of research design using a structured questionnaires based on the Philippine Recommend for Goat Production.
Place and Duration of Study: Sample: All cities and municipalities of the Province of Negros Occidental conducted from February 2021 to April 2021.
Methodology: It employed a purposive sampling technique where 25 respondents were surveyed in each municipality and/or city. The interviewed respondents were based on the farmer’s database of the local agriculture office. A total of 580 backyard goat raisers were interviewed in this study. Data gathered were coded and analyzed using the SPSS statistical software. Interpretation of data was determined using frequencies, mean, and standard deviation.
Results: Among 580 goat raisers, 57.6 % were male while the remaining 42.4% is female. In the said production, 50 years old and above dominantly engaged with 31% age, followed by 40-49, 30-39, and 20-29 age groups with 30%, 28.3%, and 9.8% respectively. Most of them were married with 81.9%. Females (46.7%) tend to raise goats for breeding purposes while males (71.6%) raised goats for meat purposes.
The majority of the male (49.1%) practice crop-livestock integration while most of the females (44.3%) practice mono-farming. Both genders have almost the same percentages when it comes to diversified farming. Moreover, in terms of goat raising system, tethering was dominantly practiced by both gender (F-91.9% & M-95.8%) followed by range (F-12.6 & M-16.5%) and feedlot (F-3.7% & M-0.9%).
Conclusion: This study observed that there are declining number of young men and women involved in livestock farming, indicating less interest in the next generation to venture into agriculture. It has also been found out that males raised goats for meat type as a source of income, practice crop-livestock integration, and feed their goats in tether and range systems. On the other hand, females raised goats for breeding for easy care, practiced mono-farming, and feed goats in the feedlot system for them to do other household activities.
Epidemiological Profile and Management of Kawasaki Syndrome at Rabat Children’s Hospital: A retrospective study from Morocco
Authors: Mebrouk Nadia , Chtouki Loubna , Bentahila Abdelali 
Published: April 2023

Kawasaki disease (KD) is a common pediatric vasculitis with a risk of coronary artery aneurysm. In this report, we review some particularities of KD disease, especially coronary involvement, and highlight its aspects during the COVID-19 epidemic which saw the emergence of a syndrome named multisystem inflammatory syndrome in children (MIS-C). Because of its many similarities with KD, MIS-C is often referred to as Kawasaki-like disease (KLD) or pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS).We report on a retrospective study on the different epidemiological, clinical, and evolutionary aspects of KD and the coronary involvement resulting from this disease before and after the pandemic. The study is based on the echocardiography records of the P4 Department at Rabat Children’s Hospital, from January 2002 to December 2021. A total of 379 patients were diagnosed with KD during that period. This includes 47 cases that were reported during the first year of the COVID-19 epidemic in Morocco (March 2020). Echocardiography results for our series show that cardiac complications wererelatively more frequent among KD patients during the COVID-19 period, perhaps because they were relatively older (67 months on average) than classic KD patients (37 months on average). However, all patients had a favorable outcome after treatment with a combination of intravenous immunoglobulin (IVIG) and aspirin. The few patients who did not respond to standard treatment received corticosteroids, and no mortality occurred. We conclude that as far as cardiac complications,KD, KLD, and MIS-C are the same core disease that is triggered under different conditions for different age groups.The emergence of the Sars-Cov-2 virus changed the epidemiologic profile of KD but not its treatment. Insights from this study would help in the decision to initiate targeted immunotherapy quickly and reduce the risk factors associated with KD.
Effect of Hayani Date (Phoenix dactylifera L) Peels on Blood Sugar, Blood Lipids, Liver and Kidney Functions, and Inflammation in Diabetic Rats
Authors: Elbadrawy Elsayed , Elzainy Ashraf , Elkewawy Hala , Elsaid Nagia 
Published: April 2023

This study aimed to investigate the effect of Hayani date peel powder and its methanolic extract on glycemia and lipidemia in streptozotocin-induced diabetic rats as well as their effects on kidney and liver functions in addition to their anti-inflammatory activity. Twenty-four rats were used in this study, six of them served as normal control (group 1) which continued feeding on the basal diet, while the remaining 18 rats were injected with streptozotocin (50mg/kg) to induce diabetes. The diabetic rats were divided into three groups (6 rats each), one of them feeding on the basal diet only which acted as diabetic control (group 2), another group fed on the basal diet and treated orally with the peel extract in a concentration of 250 mg/kg body weight (group 3), while the third group was treated with peel powder merged in the basal diet with a concentration of 5% w/w (group 4). The results showed that the extract and the powder of the peels significantly decreased the blood glucose, glycated hemoglobin (HbAlc), total cholesterol (TC), total triglycerides (TG), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), alanine transaminase (ALT), aspartate transaminase (AST), creatinine, and uric acid as well as cyclooxygenase-2 (COX-2), prostaglandin 2 (PGE2), tumor necrosis factor alpha (TNF-α), interleukin 1B (IL-1β), and inducible nitric oxide synthase (iNOS) levels. In contrast, significant increases in serum insulin, high density lipoprotein cholesterol (HDL-c), and albumin were noticed in comparison to diabetic control. Generally, the peel extract was more effective than the peel powder. It is recommended by eating the whole fruit of date without peeling.
Mental Health Effects of COVID-19 Pandemic on Learners in Primary and Secondary Schools in Kenya
Authors: Mbutitia Francisca , Mburugu Beatrice , Chepchieng Micah , Kung’u Lucy , Ngure Peter , Raburu Pamela , Kangethe Mary , Maina Grace Ngugi , Avisa Hellen , Gitau Susan 
Published: April 2023

Aims: To assess the effect of COVID -19 on mental health of the learners in primary and secondary schools of Kenya.
Study Design: The study adopted a cross-sectional research design where 96.5% of the respondents of the study were between the age of 6- 18 years.
Place and Duration of the Study: The study was conducted in Kenya and it involved five counties namely Nairobi, Mombasa, Kajiado, Migori and Elgeyo Marakwet primary, secondary and special schools. The study was conducted between October 2021 and July, 2022.
Methodology: In the five selected counties 12 schools were selected in each county where different sub-counties were considered. A 31 item paper questionnaire for learners on mental health was administered to assess levels for anxiety with ten(10) items, depression had eleven(11) items and and post-traumatic stress disorder had ten (10) items. The learners responded to a 3 point Likert scale of; “Not at all”(1) “Sometimes”(2) and “All the Time”(3) The scores were tabulated as follows: Anxiety; Normal 10 – 15, Mild 16 -20, Moderate 21- 25 and Severe 25 and above, Depression; Normal 11 – 18, Mild 19 -26, Moderate 27- 31 Severe 32 and above and finally Scores for PTSD; Normal 9 – 14, Mild 15 -19, Moderate 20- 24, Severe 25 and aboveNormal (1), Mild (2), Moderate (3) and Severe (4) though some items were reverse scored if the statement was negatively phrased. All the learners who scored an average of moderate to severe in this tool were identified as vulnerable and predisposed to risks of mental illness and therefore recommended for mental health interventions.
Results: The study established that 25.7% of the learners reported moderate to severe levels of anxiety, 27.9% of the learners reported moderate to severe levels of depression and 44.4% of the learners reported moderate to severe levels of PTSD.
Conclusion: The study established that there were heightened level of anxiety was a reality among school learners. There is need to implement efforts that address depressive symptoms before they escalate to unmanageable levels. Learners are experiencing post-traumatic stress disorder whose effects will continue to be felt for long period of time unless intervention takes place. Therefore Kenyan schools not only need to prevent but also manage learners exhibiting the mental health symptoms to promote holistic growth with fully functional citizenry.
Macrophages – Controlling the Bifurcation Between Tumor Existence or Regression
Authors: Novobrantseva Tatiana , Manfra Denise , Nguyen Ani , Feldman Igor 
Published: April 2023

AbstractMacrophages are multifunctional cells that are employed by the tumor to further its growth and adaptation. While tumor‐associated macrophages (TAMs) have widely diverse phenotypes, tumors coevolve with the ones that can promote tumorigenesis. Functionally, TAMs/myeloid cells constitute the largest negative influence on the tumor microenvironment and need to be reprogrammed in order to enable successful anti‐tumor response in most tumors. It is predicted that successful TAM repolarization has the potential to become a staple of immuno‐oncology across most indications.
Neutralization of Cannabidiol Neurotoxicity in Neuron‐Astrocyte Sandwich Coculture
Authors: Kim Jungnam , Yang Seoin , Choi Insung S. 
Published: April 2023

AbstractCannabidiol (CBD), a main nonpsychoactive phytocannabinoid in the Cannabis genus, has been in the limelight for its potential health benefits in various neurological diseases. However, the safety issue of CBD in the nervous system has not been settled fully, while CBD has been reported to have mild side effects including dizziness and somnolence. In this work, a platform of neuron‐astrocyte sandwich coculture to investigate the neurotoxicity of CBD, as well as the neuronal responses to CBD, in a more in vivo relevant mode is constructed. CBD (15 and 30 µm) causes the viability decrease, along with morphological damage, in the neuron‐alone culture, whereas its neurotoxic effects are significantly attenuated by the supports of astrocytes in the neuron‐astrocyte coculture. In addition, it is found that CBD‐induced increase of intracellular Ca2+ concentration and depolarization of mitochondrial membrane potential, via activation of transient receptor potential vanilloid 1, are noticeably ameliorated by coculturing neurons with astrocytes. This work provides crucial information in the development of CBD as therapeutics for neurological disorders, as well as in a fundamental understanding of how CBD works in the nervous system.
A Low‐Hysteresis and Highly Stretchable Ionogel Enabled by Well Dispersed Slidable Cross‐Linker for Rapid Human‐Machine Interaction
Authors: Du Ruichun , Bao Tianwei , Zhu Tangsong , Zhang Jing , Huang Xinxin , Jin Qi , Xin Ming , Pan Lijia , Zhang Qiuhong , Jia Xudong 
Published: April 2023

AbstractIonic conductive soft materials for mimicking human skin are a promising topic since they can be thought of as a possible basis for biomimetic sensing. In pursuit of devices with a long working range and low signal delay, conductive materials with low hysteresis and good stretchability are highly demanded. To overcome the challenges of highly stretchable conductive materials with good resilience, herein a chemical design is proposed where polyrotaxanes act as topological cross‐linkers to enhance the stretchability by sliding‐induced reduced stress concentration while the compatible ionic liquid is introduced as a dispersant for low hysteresis. The obtained ionogels exhibit versatile properties more than low hysteresis (residual strain = 7%) and good stretchability (550%), and also anti‐fatigue, biocompatibility, and good adhesion. The low hysteresis is attributed to lower energy dissipation from the well‐dispersed polyrotaxanes by compatible ionic liquids. The mechanism provides a new insight in fabricating highly stretchable and low‐hysteresis slide‐ring materials. Furthermore, the conductivity of the ionogels and their responses to strains and temperatures are measured. Benefiting from the good conductivity and low hysteresis, the ionogel is applied to develop a wireless communication system to realize rapid human‐machine interactions.
A Self‐Assembly Combined Nano‐Prodrug to Overcome Gemcitabine Chemo‐Resistance of Pancreatic Tumors
Authors: Yao Zhuo , Hu Qida , Jin Piaopiao , Li Bowen , Huang Yong , Zhang Fu , Wang Meng , Huang Junming , Huang Jing , Shao Shiyi , Zhao Xinyu , Ping Yuan , Liang Tingbo 
Published: April 2023

AbstractGemcitabine (GEM), as a first‐line chemotherapeutics for pancreatic ductal adenocarcinoma (PDAC) treatment, still faces several clinical challenges, restricted by instability in blood circulations, low tumor selectivity, and acquired nature characteristics of chemo‐resistance. To solve these challenges, the rational design of combination therapy with GEM and other therapy modalities is imperative. Herein, a small molecular self‐assembly nano‐prodrug is developed, which can achieve the co‐delivery of GEM, Ferrocene and nutlin‐3a on the achievement of GEM‐induced apoptosis with ferroptosis. In this nano‐prodrug, the disulfide linkage not only acts as a GSH‐responsive trigger but also plays an important role in self‐assembly behavior of nanoparticle that can load nutlin‐3a. Interestingly, nutlin‐3a plays an important role in both ferroptosis and apoptosis, one is effectively sensitized cells to ferroptosis by inhibiting cystine uptake, and the other is promoted apoptosis by elevating p53 expression. To further enhance the drug tumor accumulation and maintain stability in systemic circulations, this nano‐prodrug is then encapsulated into plectin1 receptor‐targeting phospholipid micelles (DSPE‐PEG‐PTP), which displays high selective tumor inhibition and good biosafety on different mice models, especially in orthotopic and patient‐derived xenograft (PDX) models. The findings provide new insights into the combination therapy of GEM with ferroptosis for reduced chemo‐resistance on PDAC treatment.