bluuebunny/crossref_metadata_2025_split huggingface dataset:
A seven-Lnc RNA signature for prognosis prediction of patients with lung squamous cell carcinoma through tumor immune escape
Authors: lin zhong , hu yan 
Published: May 2023

Abstract
Lung squamous cell carcinoma (LUSC) is a malignant disease with poor therapeutic response and a poor prognosis. Some basic researches had confirmed that dysregulation of long non-coding RNAs (LncRNAs) was associated with cancer development and prognosis. However, related studies in LUSC are rare. In this paper, we purposed to develop a group LncRNAs signature to improve prognosis prediction of LUSC and describe the underlying mechanism. The LncRNAs expression and related clinical information of 471 patients with LUSC from TCGA randomly divided into a training set (n = 236) and a testing set (n = 235). A seven-LncRNAs prognostic signature model were constructed with the data of training group by multivariate Cox regression. All patients were divided into high risk group (n = 101) and low risk group (n = 370) according to the risk-score level calculated by the constructed model at the cutoff value of -0.12 (log2-transformed). The high risk group had a significantly worse overall survival (OS) compared to the low risk group (p < 0.0001). The risk-score also displayed an excellent prognostic predictive ability for LUAC patients by the results of ROC curve (AUC:0.66, 0.67 and 0.67) and nomogram (C-index, Calibration analysis, and Decision Curve Analysis) in years 1, 3, and 5. The risk group [HR = 0.3, 95%CI (0.22–0.4)], stage [HR = 1.78, 95%CI (1.28–2.48)] and age [HR = 1.02, 95%CI (1.00-1.04)] were as an independent predictor among LUAC patients. KEEG enrichment revealed that the mRNA influenced by the hunted seven LncRNAs which involved in immune escape function may be mainly related to the pathway of Chemical carcinogenesis, Th17 cell differentiation, NF − κB and Proteoglycans in cancer, etc. And the CIBERSORT score calculated from the expression level of the immune cell rerated gene between the normal cell and LUSC cell were showed that the immune system in the LUSC patients was activated. To sum up, our study demonstrated the potential clinical significance of 7-LncRNA characteristics in the prediction of survival in patients with LUSC.
Dislocations after total hip arthroplasty by direct anterior approach: An overview on dislocations after total hip arthroplasty by direct anterior approach; A retrospective study of 2933 procedures with one-year follow-up.
Authors: Oosting Ellen , Yau Chris L. , Reniers Luca I. , Duit Robin A. , Kapitein Paul J.C. 
Published: May 2023

Abstract
Aims: The use of the direct anterior approach (DAA) for total hip arthroplasty (THA) has increased but occasions for dislocations and treatment, course and the outcome after dislocation are rarely evaluated. Therefore, in this study we aim to give an overview of dislocations after THA by DAA.
Material and methods: We retrospectively analyzed all patients who had THA by DAA for osteoarthritis (OA) between 2014 and 2019 with 1-year follow-up in our hospital. We studied occasions and risk factors and compared outcome of hip function at 1-year follow-up by use of the Oxford Hip Score (OHS) for patients with and without dislocation.
Results: A total of 2933 patients were included. Dislocation rate was 0.7% (n=21). 15 patients had a single dislocation, 6 patients had a second dislocation (29%) of which 1 had a third dislocation. Of the dislocations, 81% (17/21) were in the anterior direction and 86% (18/21) were in the first postoperative month. Most dislocations took place when patients were sitting, sitting and turning or getting up from a chair (n=9). Patients with a dislocation had a higher Body Mass Index than those without a dislocation (29.6 vs 27.0 kg/m2, 95% CI -4.4 to -0.7, p=0.007). Five patients had revision surgery (24%). OHS at 1y-FU (42 vs 44, 95% CI -1.2 to 5.2, p=0.25) and mean change (16 vs 18, 96% CI -2.1 to 7.3, p=0.22) did not significantly differ between patients with or without dislocation.
Conclusion: Dislocation rate after THA by DAA is low and causes vary. Outcomes after dislocation can still be satisfying, as Oxford Hip Scores at 1-year follow-up were comparable for those with and without dislocation, especially for those with conservative treatment. These findings may support shared decision in treatment strategies and information for patients with a dislocation.
On the usage of the Aviation Colour Code system at European Volcano Observatories: experiences and open questions
Authors: Barsotti Sara , Scollo Simona , Macedonio Giovanni , Rielo Alicia Felpeto , Peltier Aline , Vougioukalakis Georgios , Dalfsen Elske de Zeeuw - van , Ottemöller Lars , Pimentel Adriano , Komorowski Jean-Christophe , Loughlin Susan , Carmo Rita , Coltelli Mauro , Corbeau Jordane , Vye-Brown Charlotte , Vito Mauro Di , de Chabalier Jean-Bernard , Ferreira Teresa , Fontaine Fabrice R. , Lemarchand Arnaud , Marques Rui , Medeiros Joana , Moretti Roberto , Pfeffer Melissa Anne , Saurel Jean-Marie , Vlastelic Ivan , Vogfjörd Kristín 
Published: May 2023

Abstract
Volcano Observatories (VOs) around the world are required to maintain surveillance of their volcanoes and inform civil protection and aviation authorities about impending eruptions. They often work through consolidated procedures to respond to volcanic crises in a timely manner and provide a service to the community aimed at reducing the potential impact of an eruption. Within the International Airways Volcano Watch (IAVW) framework of the International Civil Aviation Organisation, designated State Volcano Observatories (SVOs) are asked to operate a colour coded system designed to inform the aviation community about the status of a volcano and the expected threats associated. Despite the IAVW documentation defining the different colour-coded levels, operating the Aviation Colour Code (ACC) in a standardised way is not easy, as sometimes, different SVOs adopt different strategies on how, when, and why to change it. Following two European VOs and Volcanic Ash Advisory Centres (VAACs) workshops, the European VOs agreed to present an overview on how they operate the ACC. The comparative analysis presented here reveals that not all VOs in Europe use the ACC as part of their operational response, mainly because of a lack of volcanic eruptions since the ACC was officially established, or the absence of a formal appointment as an SVO. We also note that the VOs, which do regularly adopt ACC, operate differently depending on the frequency and styles of eruptions, the historical eruptive activity, the nature of the unrest, the monitoring level, and also on the agreement they may have with the local Air Transport Navigation providers. This study shows that even though the ACC system was designed to provide a standard, its usage strongly depends on the evaluation of the actors responding to the volcano emergencies. Some common questions have been identified across the different (S)VOs that will need to be addressed by ICAO in order to have a more harmonised approach and usage of the ACC.
Electromagnetic signatures of chiral quantum spin liquid
Authors: Lin Shi-Zeng , Banerjee Saikat , Zhu W. 
Published: May 2023

Abstract
Quantum spin liquid (QSL) has become an exciting topic in interacting spin systems that do not order magnetically down to the lowest experimentally accessible temperature; however, conclusive experimental evidence remains lacking. Motivated by the recent surge of theoretical and experimental interest in a half-filled Hubbard model on the triangular lattice, where chiral QSL can be stabilized, we investigate the electromagnetic signature of the chiral QSL to aid experimental detection. We systematically studied the electrical charge and orbital electrical current associated with a spinon excitation in the chiral QSL based on parton mean-field theory and unbiased density-matrix renormalization group calculations. We then calculated both longitudinal and transverse optical conductivities below the Mott gap. We also conduct quantum field theory analysis to unravel the connection between spinon excitation and emergent and physical gauge fields. Our results show that the chiral QSL phase has a clear electromagnetic response even in a Mott insulator regime, which can facilitate the experimental detection of this long-sought-after phase.
Novel three-dimensional live skin-like in vitro composite for safety tests
Authors: Tomita Tatsunosuke , Nakajima Yoshihiro , Ohmiya Yoshihiro , Miyazaki Koyomi 
Published: May 2023

Abstract
We describe the construction of novel three-dimensional (3D) skin-like cultures of spontaneously immortalised normal keratinocytes derived from human HaCaT cells using a non-woven membrane of silica fibre in differentiation medium. Analyses of skin differentiation markers in a 3D-skin-like in vitro composite (SLIC) revealed the expression of keratin 2, keratin 10, filaggrin, and involucrin, indicating mature skin characteristics. We further engineered SLIC to incorporate real-time bioluminescence monitoring driven by the IL-8 and UBC genes. We also monitored the time- and dose-dependent responses of SLIC to UV stress, and to hydrophilic chemicals, and hydrophobic ones which are difficult to assay so far as they do not disperse in water. We propose that SLIC could serve as a novel alternative to using animals to test the safety of various chemicals on skin for medical, cosmetic purposes.
Diaspora of The Skilled: What Is The Role of Institutions?
Authors: Chen Fanyu , Wong Vivien Zi Wen , Law Siong Hook 
Published: May 2023

Abstract
Brain drain is closely associated with human capital deficiencies and obstacles in economic development. In spite of its crucial economic implications, nations, especially the developing ones, have failed to prevent brain drain due to the focus on simple restrictive policies and the ignorance of institutional factors like weakly-enforced law and order, unfulfilled basic human rights, and others in preventing the outflow high skilled labor. Thus, this paper aims to investigate the impact of institutional quality on brain drain in 100 countries from 2007 to 2019, using system Generalized Method of Moments estimator to estimate the model involving data collected from the International Country Risk Guide, The Quality of Government Institute, and the World Bank. The empirical results indicated that quality of institutions is essential in preventing the outflow of highly skilled workers. It has become imperative for policy-makers in these countries to uphold and strengthen their nations’ institutional frameworks in order to retain and attract the valuable talents to stay on and reside in their own countries.
Assistance Force-line of Exosuit Affects Ankle Multidimensional Motion: A Theoretical and Experimental Study
Authors: Zhang XinYue , Li Ying , Sun Ronglei 
Published: May 2023

Abstract
Background: The talocrural joint and the subtalar joint are the two major joints of the ankle-joint complex. The position and direction of the exosuit force line relative to these two joint axes can influence ankle motion. We aimed to understand the effects of different force-lines on ankle multidimensional motion.
Methods: In this article, three assistance force line schemes for ankle exosuits were proposed: perpendicular to the talocrural joint axis (PT), intersecting with the subtalar joint axis (IS), and parallel to the triceps surae (PTS). A theoretical model was proposed to calculate the exosuit's assistance moment. Seven participants completed four experimental tests of ankle plantar flexion, including three passive motions assisted by the PT, PTS, and IS, and one active motion without exosuit assistance.
Results: The simulation results showed that all three exosuit schemes produced considerable ankle plantarflexion moments. Among the three schemes, the PT scheme generated the highest moments in all three dimensions, followed by the PTS and IS schemes. The experimental findings revealed that there was no significant difference in the angle of plantarflexion between passive and active plantarflexion (P < 0.05). However, there was an increase in the average peak angle of ankle inversion and adduction compared to no assistance, with the increment of approximately 21.07°, 6.57°, and 2.41° for inversion and 8.29°, 2.65°, and 0.33° for adduction, respectively. Our study demonstrated that all three exosuit schemes were beneficial for ankle plantar flexion. The IS scheme had the least effect on ankle inversion/eversion and adduction/abduction and was most similar to active ankle plantarflexion in all three directions compared to the other two schemes.
Conclusions: Our research indicates that the position of the exosuit force line to the subtalar joint has a significant impact on ankle inversion and adduction. Among all three schemes, the IS, which has almost no effect on the subtalar joint, has the greatest kinematic similarity to active ankle plantarflexion and might be a better choice for ankle assistance and rehabilitation.
Development and preclinical assessment of nanoemulgel loaded with phytoconstituents for the management of rheumatoid arthritis
Authors: Chando Anita , Basudkar Vivek , Gharat Sankalp , momin Munira , Khan Tabassum 
Published: May 2023

Abstract
In recent years, natural ingredients have gained importance for therapeutic treatment due to their minimal toxicity. However, the delivery of these phytoconstituents poses a challenge to provide better efficacy. Current research reports the development of nanoemulgel (NEG) loaded with ginger oleoresin (GOR) and lipid guggul extract (LGE) for the management of rheumatoid arthritis (RA). The nanoemulsion (NE) was developed using the spontaneous emulsification technique by the pseudo-ternary method. The optimized nanoemulsion exhibited globule size of 16.08±2.55, PDI of 0.187±0.06 and Zeta Potential of-22.4±0.31. The cumulative release from in-vitro diffusion studies at pH 7.4 was about 99.72±3.47%, 57.98±2.11% and 86.42±5.13% of 6-gingerol, E-guggulsterone and Z-guggulsterone respectively at the end of 24 hours. The ex vivo studies on porcine ear skin showed sustained release with 92.8±3.21% for 6-gingerol, 55.61±0.91% for E-guggulsterone, and 84.2±4.22% for Z-guggulsterone released at the end of 24 hours. The cell culture studies on RAW 264.7 cells indicated a robust inhibition of LPS-induced IL-6 and TNF-α production indicating its efficacy in the management of RA. The Preclinical studies on male Wistar rats suggests that the developed NEG exhibited a comparable decrease in paw edema inflammation as compared to the marketed diclofenac sodium gel. These encouraging results demonstrates the potential of the developed nanoemulgel containing combination of GOR and LGE for the management of RA.
The Measurement and Modeling of Gravitational Deformation for Large Radio Telescope Based on Wavefront Perturbation Method
Authors: Wang Jinqing , Lou Zheng , Jiang Yongbin , Sun Zhengxiong , Yu Linfeng , Zhong Weiye , Jiang Yongchen , Zhao Rongbin , Fu Li , Ye Qian , Shi Shengcai , Liu Qinghui , Zuo Yingxi 
Published: May 2023

Abstract
In this paper, the wavefront perturbation method based on power detection of radio sources is used to measure the surface error of the Tianma radio telescope. By measuring the surface errors at different elevation angles, a surface compensation model to correct gravitational deformation is established. Observation results shows that the efficiency reduction caused by the gravitational deformation can be effectively compensated by loading this model on the active surface, especially at high and low elevations. A dual-beam calibration scheme is further used to remove atmospheric background fluctuations, which significantly improves data quality at lower elevations. The form and order of the perturbation modes and data processing are optimized to improve measurement accuracy. This paper presents the first attempt to apply the wavefront perturbation method to large radio telescopes and demonstrates its capacity and effectiveness in telescope runtime surface measurement and maintenance.
The correlation between non-traumatic avascular necrosis of femoral head and insulin-like growth factor-1 and bone metabolism markers
Authors: Li Hongyi , Yang Lang , Wen Guohong , Guan Hong , Liu Guiwang , Ru Jiangying , Wang Guiqing , Wang Xiangjiang 
Published: May 2023

Abstract
Objectives: To explore the correlation and significance of serum insulin-like growth factor-1 (IGF-1) and bone metabolism markers in patients with non-traumatic avascular necrosis of femoral head (N-ANFH).
Methods: A prospective study was conducted on the patients with control and N-ANFH cohorts admitted from the orthopedic department of The Sixth Affiliated Hospital of Guangzhou Medical University from July 2020 to February 2023. The control (n=25) and N-ANFH cohorts (n=30) were randomly selected using block randomization method. The gender, age, body mass index (BMI), IGF-1, bone metabolism markers, including type I collagen hydroxyl terminal peptide β special sequence (β-CTX), N-terminal mid-fragment of osteocalcin (N-MID), total aminoterminal propeptide of type I procollagen (T-PINP), serum 25-hydroxyvitamin (D25(OH)D), parathormone and bone density, were compared between the two cohorts. Single and multiple factor logistic regression analysis were applied to study the correlation between dependent variable and N-ANFH. The expression pattern of IGF-1 in bone tissue from control and N-ANFH cohorts was detected by immunofluorescence (IF). Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DXA) scanning. Pearson correlation analysis was used to analyze the relationship between IGF-1 and BMD, the value of IGF-1 in the diagnosis N-ANFH was evaluated by receiver operating characteristic curve (ROC) analysis.
Results: The bone metabolism markers of the control cohort were significantly higher than those of the N-ANFH cohort (p< 0.05), and IF revealed that the expression level of IGF-1 in the control cohort was significantly higher than that of the N-ANFH cohort. The expression level of IGF-1 was positively correlated with hip BMD (r= 0.7569, p= 0.0001). The area under ROC curve (AUC) in the diagnosis of N-ANFH was 0.7373, p= 0.0026, with a cutoff value of 139.6, corresponding sensitivity of 80%, and a specificity of 64%.
Conclusion: The bone metabolism level of N-ANFH is significantly reduced, and IGF-1 is not only closely related to the level of osteoporosis, but also one of vital biomarkers for diagnosing N-ANFH, suggesting that decreased bone metabolism level and osteoporosis may be the main causes of N-ANFH.
Detection of African swine fever virus in archived Formalin fixed Paraffin embedded swine tissue sections in Uganda using Immunohistochemistry (IHC) and Polymerase chain reaction (PCR)
Authors: Afayoa Mathias , Ojok Lonzy , Okuni Julius Boniface 
Published: May 2023

Abstract
Background
African swine fever (ASF), a devastating viral disease of pigs, is one of the main hindrance to pig farming in sub-Saharan African. Sporadic outbreaks of the disease occur annually in various regions of Uganda most of which remain undocumented. This study employed histopathology, immunohistochemistry and conventional PCR comparatively on 290 formalin fixed paraffin embedded swine tissues in diagnosis of ASF. ASF was confirmed by conventional PCR using diagnostic primers recommended by World Organization for Animal Health, (forward primer, 5’- TGGATACCGAGGGAATAGC- 3’) and (reverse primer, 5’-CTTACCGATGAAATGATAC- 3’).
Results
It was found out that, more than a third of the archived pig lymphoid tissues, (lymph nodes 33.3%, 95/285 and spleen; 42.8%, 120/280) had lesions suggestive of ASF. In average, 17% and 15% of the archived samples had ASF viral DNA and antigen respectively. The positivity rate for ASF in the tested tissue samples was higher in spleen (PCR, 17.5% and IHC, 16.1%) than in other tissues. More than half (51.1%, 48/94) of the lymph nodes and 41.9% ( 49/117) of spleen tissues that had lesions suggestive of ASF tested positive for ASF using conventional PCR.
Conclusion
ASF is still wide spread in Uganda and is one of the major threats to pig production in the country. Immunohistochemistry other than PCR, is an effective and reliable technique for diagnosing ASF in tissues even after a long period of archiving.
Fatal Iatrogenic Cerebral Amyloid-Related Encephalitis in a patient treated with lecanemab for Alzheimer’s disease: neuroimaging and neuropathology.
Authors: Schrag Matthew , Solopova Elena , Romero-Fernandez Wilber , Harmsen Hannah , Antunes Lissa Ventura , Wang Emmeline , Maldonado Jose , Shostak Alena , Donahue Manus , Schultz Daniel , Coyne Thomas , Charidimou Andreas 
Published: May 2023

Abstract
We report the case of a 79-year-old woman in good general health aside from early-stage Alzheimer’s disease who was enrolled in a randomized controlled trial of the novel therapeutic monoclonal antibody lecanemab where she was treated with the placebo, and subsequently in the open label extension study where she received lecanemab infusions every two weeks. After the third infusion, she suffered a seizure followed by aphasia and progressively worsening encephalopathy. Magnetic resonance imaging revealed multifocal cerebral edema and an increased burden of cerebral microhemorrhages compared to pre-trial imaging, consistent with Amyloid Related Imaging Abnormality (ARIA). She was treated with an antiepileptic regimen and high-dose intravenous corticosteroids but continued to worsen and expired after five days in the hospital. The family requested an autopsy and consented to evaluation of her brain for research. Post-mortem MRI confirmed extensive microhemorrhagic changes in the temporal, parietal and occipital lobes, some of which were visible on gross inspection of the brain. Autopsy confirmed APOE genotype of E4/E4 and the presence of typical neuropathological features of Alzheimer’s disease along with severe cerebral amyloid angiopathy with inflammatory features, including perivascular lymphocytic infiltrates, reactive macrophages and fibrinoid degeneration of vessel walls. There were deposits of β-amyloid in meningeal vessels and penetrating arterioles with numerous microaneurysms. Cerebral microhemorrhages were associated with arterioles harboring β-amyloid deposits and having degenerative morphologies. We conclude from these results that the patient likely died as a result of severe cerebral amyloid angiopathy with marked microvascular degeneration and meningoencephalitis. Further study of the mechanism of ARIA and the neuropathological changes associated with plaque clearance are needed.