bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term multiwavelength monitoring and reverberation mapping of NGC 2617 during a changing-look event
Authors: Oknyansky V L , Brotherton M S , Tsygankov S S , Dodin A V , Tatarnikov A M , Du P , Bao D -W , Burlak M A , Ikonnikova N P , Lipunov V M , Gorbovskoy E S , Metlov V G , Belinski A A , Shatsky N I , Zheltouhov S G , Maslennikova N A , Wang J -M , Zhai S , Fang F -N , Fu Y -X , Bai H -R , Kasper D , Huseynov N A , McLane J N , Maithil J , Zastrocky T E , Olson K A , Chen X , Chelouche D , Oknyansky R S , Buckley D A H , Tyurina N V , Kuznetsov A S , Rebolo R L , Zhao B -X 
Published: August 2023

ABSTRACT
We present the results of photometric and spectroscopic monitoring campaigns of the changing look AGN NGC 2617 carried out from 2016 until 2022 and covering the wavelength range from the X-ray to the near-IR. The facilities included the telescopes of the SAI MSU, MASTER Global Robotic Net, the 2.3-m WIRO telescope, Swift, and others. We found significant variability at all wavelengths and, specifically, in the intensities and profiles of the broad Balmer lines. We measured time delays of ∼6 d (∼8 d) in the responses of the Hβ (Hα) line to continuum variations. We found the X-ray variations to correlate well with the UV and optical (with a small time delay of a few days for longer wavelengths). The K-band lagged the B band by 14 ± 4 d during the last three seasons, which is significantly shorter than the delays reported previously by the 2016 and 2017–2019 campaigns. Near-IR variability arises from two different emission regions: the outer part of the accretion disc and a more distant dust component. The HK-band variability is governed primarily by dust. The Balmer decrement of the broad-line components is inversely correlated with the UV flux. The change of the object’s type from Sy1 to Sy1.8 was recorded over a period of ∼8 yr. We interpret these changes as a combination of two factors: changes in the accretion rate and dust recovery along the line of sight.
astrophot: fitting everything everywhere all at once in astronomical images
Authors: Stone Connor J , Courteau Stéphane , Cuillandre Jean-Charles , Hezaveh Yashar , Perreault-Levasseur Laurence , Arora Nikhil 
Published: August 2023

ABSTRACT
We present astrophot, a fast, powerful, and user-friendly python based astronomical image photometry solver. astrophot incorporates automatic differentiation and graphics processing unit (GPU), or parallel central processing unit (CPU), acceleration, powered by the machine learning library pytorch. Everything: astrophot can fit models for sky, stars, galaxies, point spread functions (PSFs), and more in a principled χ2 forward optimization, recovering Bayesian posterior information and covariance of all parameters. Everywhere: astrophot can optimize forward models on CPU or GPU; across images that are large, multiband, multi-epoch, rotated, dithered, and more. All at once: The models are optimized together, thus handling overlapping objects and including the covariance between parameters (including PSF and galaxy parameters). A number of optimization algorithms are available including Levenberg–Marquardt, Gradient descent, and No-U-Turn Markov chain Monte Carlo sampling. With an object-oriented user interface, astrophot makes it easy to quickly extract detailed information from complex astronomical data for individual images or large survey programs. This paper outlines novel features of the astrophot code and compares it to other popular astronomical image modelling software. astrophot is open-source, fully python based, and freely accessible at https://github.com/Autostronomy/AstroPhot .
Association between individual resilience and depression or anxiety among general adult population during COVID-19: a systematic review
Authors: Yap Mei Chen , Wu Fei , Huang Xulei , Tang Lingli , Su Kehan , Tong Xin , Kwok Sze Chai , Wu Chenkai , Wang Shan , He Zhengting , Yan Lijing L 
Published: August 2023

Abstract

Background
The coronavirus disease (COVID-19) pandemic exacerbated depression and anxiety worldwide. Resilience is important to maintain mental health during uncertain times, but limited study has systematically reviewed its association with depression or anxiety with an emphasis on the general population.

Methods
We searched PubMed and Embase for quantitative or mixed-methods studies on the general adult population published between 1 January 2020 and 31 April 2022 (PROSPERO ID: CRD 42022340935). National Institute of the Health quality assessment tools was used to assess the risk of bias. We qualitatively synthesized findings by outcome and study design.

Results
A total of 2945 studies were screened and 35 studies were included in the narrative analysis (5 on depression, 9 on anxiety, and 21 on both). Overall, 21 studies identified statistically significant inverse associations between resilience and depression, while 24 studies found statistically significant inverse associations between resilience and anxiety. Eight studies reported no statistically significant relationships between resilience with depression or anxiety.

Conclusions
Resilience was found to be inversely associated with depression and anxiety during the COVID-19 pandemic. The findings highlight the importance of resilience-enhancing intervention in migrating the global mental health burden from outbreaks of infectious diseases.
A Novel Method to Determine the Maximum Output of Individual Patients for an Active Transcutaneous Bone Conduction Implant Using Clinical Routine Data
Authors: Ghoncheh Mohammad , Busch Susan , Lenarz Thomas , Maier Hannes 
Published: August 2023

Objectives:
The maximum output provided by a bone conduction (BC) device is one of the main factors that determines the success when treating patients with conductive or mixed hearing loss. Different approaches such as sound pressure measurements using a probe microphone in the external auditory canal or a surface microphone on the forehead have been previously introduced to determine the maximum output of active transcutaneous BC devices that are not directly accessible after implantation. Here, we introduce a method to determine the maximum output hearing level (MOHL) of a transcutaneous active BC device using patients’ audiometric data.

Design:
We determined the maximum output in terms of hearing level MOHL (dB HL) of the Bonebridge using the audiometric and direct BC threshold of the patient together with corresponding force levels at hearing threshold and the maximum force output of the device. Seventy-one patients implanted with the Bonebridge between 2011 and 2020 (average age 45 ± 19 years ranging from 5 to 84 years) were included in this study. The analyses of MOHLs were performed by (1) dividing patients into two groups with better or worse average audiometric BC threshold (0.5, 1, 2, 4 kHz), on the ipsilateral side or (2) by separating the MOHLs based on better or worse frequency-by-frequency specific audiometric BC thresholds on the ipsilateral (implanted) side.

Results:
When using a frequency-by-frequency analysis obtained average ipsilateral MOHLs were in the range between 51 and 73 dB HL for frequencies from 0.5 to 6 kHz in the group with better audiometric BC threshold on the ipsilateral ears. The average contralateral MOHLs in the group with better contralateral hearing were in the range from 43 to 67 dB HL. The variability of the data was approximately 6 to 11 dB (SDs) across measured frequencies (0.5 to 6 kHz). The average MOHLs were 4 to 8 dB higher across frequencies in the group with better audiometric BC threshold on the ipsilateral ears than in the group with better audiometric BC threshold on the contralateral ears. The differences between groups were significant across measured frequencies (t test; p < 0.05).

Conclusions:
Our proposed method demonstrates that the individual frequency-specific MOHL on the ipsilateral and contralateral side of individual patients with a transcutaneous BC device can be determined mainly using direct and audiometric BC threshold data of the patients from clinical routine. The average MOHL of the implant was found 4 to 8 dB higher on the ipsilateral (implanted) side than on the contralateral side.
MicroRNAs in idiopathic inflammatory myopathies: state-of-the-art and future perspectives
Authors: Pettorossi Federico , Gasparotto Michela , Ghirardello Anna , Franco Chiara , Ceolotto Giulio , Giannella Alessandra , Iaccarino Luca , Zanatta Elisabetta , Doria Andrea , Gatto Mariele 
Published: August 2023

Purpose of review
Idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune disorders characterized by muscle weakness and inflammation. MicroRNAs (miRNAs) are the main class of small noncoding RNAs regulating a wide range of physiological and pathological processes and play a role in mediating autoimmunity and inflammation. In this review, we summarize the latest knowledge on the role of miRNAs in systemic autoimmune diseases with particular focus on IIMs.

Recent findings
Study on miRNA expression in IIMs is helping in understanding the pathogenetic basis of the disease at a tissue and systemic level. Several miRNAs, even with a muscle-specific expression (myomiRs), have been shown to be involved in immune and nonimmune mechanisms of myofiber damage. MiRNAs modulate and orchestrate the local inflammatory infiltrate and could be used as potential biomarkers as they correlate with disease activity and response to therapy.

Summary
IIMs comprise different clinical phenotypes and still little is known about the molecular signature of each subset. Further research about miRNA profiling will provide additional insights in the disease characterization with an expected impact on the therapeutic strategies.
Differentiating Radiation Necrosis and Metastatic Progression in Brain Tumors Using Radiomics and Machine Learning
Authors: Salari Elahheh , Elsamaloty Haitham , Ray Aniruddha , Hadziahmetovic Mersiha , Parsai E. Ishmael 
Published: August 2023

Objectives:
Distinguishing between radiation necrosis (RN) and metastatic progression is extremely challenging due to their similarity in conventional imaging. This is crucial from a therapeutic point of view as this determines the outcome of the treatment. This study aims to establish an automated technique to differentiate RN from brain metastasis progression using radiomics with machine learning.

Methods:
Eighty-six patients with brain metastasis after they underwent stereotactic radiosurgery as primary treatment were selected. Discrete wavelets transform, Laplacian-of-Gaussian, Gradient, and Square were applied to magnetic resonance post-contrast T1-weighted images to extract radiomics features. After feature selection, dataset was randomly split into train/test (80%/20%) datasets. Random forest classification, logistic regression, and support vector classification were trained and subsequently validated using test set. The classification performance was measured by area under the curve (AUC) value of receiver operating characteristic curve, accuracy, sensitivity, and specificity.

Results:
The best performance was achieved using random forest classification with a Gradient filter (AUC=0.910±0.047, accuracy 0.8±0.071, sensitivity=0.796±0.055, specificity=0.922±0.059). For, support vector classification the best result obtains using wavelet_HHH with a high AUC of 0.890±0.89, accuracy of 0.777±0.062, sensitivity=0.701±0.084, and specificity=0.85±0.112. Logistic regression using wavelet_HHH provides a poor result with AUC=0.882±0.051, accuracy of 0.753±0.08, sensitivity=0.717±0.208, and specificity=0.816±0.123.

Conclusion:
This type of machine-learning approach can help accurately distinguish RN from recurrence in magnetic resonance imaging, without the need for biopsy. This has the potential to improve the therapeutic outcome.
Another Day, Another 82 Cents: A National Survey Assessing Gender-based Wage Differences in Board-certified Plastic Surgeons
Authors: Raborn Layne N. , Gokun Yevgeniya , Molina Bianca J. , Janse Sarah , Schoenbrunner Anna R. , Janis Jeffrey E. 
Published: August 2023

Background:
Of 7461 actively practicing United States American Board of Plastic Surgery certified plastic surgeons, only 17% are women. In relation to this small number, gender inequities within the field have been the source of national discussions. Our study assessed the status of the gender-based wage-gap in plastic surgery and sought to identify possible causes.

Methods:
An anonymous 43-question survey was distributed to 2981 members of the American Society of Plastic Surgeons in 2021. Male and female responses were compared; an analysis also considering board-certification year was performed. Chi-square and Fisher exact tests were used for bivariate analysis. Continuous variables were compared with two-sample t tests and Wilcoxon rank sum tests.

Results:
Ten percent of contacted American Society of Plastic Surgeons members responded to our survey. Of the 288 respondents, 111 (38.5%) were women, and 177 (61.5%) were men. Men were more likely to have salaries over $400K USD per year (P < 0.0001). Earlier certification year was associated with pay greater than $400K per year (P = 0.0235) but was insignificant once stratified by gender (women: P = 0.2392, men: P = 0.7268). Earlier certification year was associated with production-based and self-determined wages (P = 0.0097), whereas later board-certification year was associated with nonnegotiable salaries (P < 0.0001).

Conclusions:
Women are significantly less likely to make salaries comparable to those of male plastic surgeons, related to shorter careers on average. An increase in female representation and career duration within the field is needed to improve the current wage-gap.
Botulinum Toxins and Lip Repositioning Surgery with Repeated Botulinum Toxin Injection: A Combined Approach for Gummy Smile Treatment
Authors: Adel Noury 
Published: August 2023

Summary:
This study was conducted to evaluate the longevity and efficacy of neurotoxin injection before lip repositioning surgery in addition to reinjection of two sustaining doses along three different postoperative intervals (2, 4, and 8 months). This experimental study included 10 female patients who had a gummy smile resulting from upper lip hypermobility or short upper lip. Preoperative measurements were taken during spontaneous smiling: the interlabial distance and the amount of gingival exposure. IncoBotulinum Toxin A was injected into the elevator muscles of the upper lip followed by performing the lip repositioning surgery after 2 weeks of IncoBotulinum Toxin A injection. IncoBotulinum Toxin A was then reinjected at three different postoperative intervals (2, 4, and 8 months). All patients were followed up at 14 days, 4 months, 8 months, and 12 months. Postoperative measurements at 14 days follow-up showed a significant reduction in the amount of gum exposure and in the interlabial distance during smiling. Both changes remained stable up to 1 year, despite the minimal relapse that was observed; all the patients reported a high degree of satisfaction. Combining neurotoxins before and after the lip repositioning surgery may provide long-lasting results up to 1 year and better stability for the success rate of the surgery, where the use of each approach alone (IncoBotulinum Toxin A alone/surgery alone) may offer a temporary improvement.
SUBRETINAL FLUID ASSOCIATED WITH PEMIGATINIB THERAPY FOR CHOLANGIOCARCINOMA: A CASE REPORT AND LITERATURE REVIEW
Authors: Caranfa Jonathan T. , Mellen Phoebe , Liang Michelle C. 
Published: August 2023

Purpose:
To describe the retinal findings associated with pemigatinib, an oral competitive inhibitor of fibroblast growth factor receptor approved for the treatment of cholangiocarcinoma.

Methods:
A case report is presented, and a literature review was performed, revealing only two prior reported cases of pemigatinib-mediated subretinal fluid.

Results:
A 72-year-old woman presented with transient visual symptoms while on pemigatinib for the treatment of cholangiocarcinoma. Optical coherence tomography revealed subfoveal subretinal fluid bilaterally that resolved during a drug holiday; however, it fluctuated throughout her treatment course. She remained on pemigatinib for 10 months without other ocular sequelae.

Conclusion:
This is one of the few reported cases of pemigatinib-related retinopathy, which further supports the self-limited and benign nature of subretinal fluid associated with fibroblast growth factor receptor inhibitors.
Student Experiences of a Home-Based Acute Care Curriculum
Authors: Trojanowski Suzanne , Sherman Erica , Huang Min Hui 
Published: August 2023

Background/Purpose:
The COVID-19 pandemic disrupted physical therapy education beginning in March 2020. Acute care physical therapy is complex and has substantive psychomotor skills and safety demands. Students can experience significant challenges during acute care clinical education experiences (CEE); therefore, assessment of the effect of curricular adjustments on preparation for clinical experiences is paramount. Students can experience significant challenges during acute care CEE. Educational programs continue to assess the effect of pandemic dictated altered modes of delivery of laboratory-based courses on student outcomes. The purpose of this qualitative case report is to explore students' experiences of an online delivery mode of an acute care course and their perception of its ability to prepare the student for an acute care CEE.

Case Description:
Interviews were completed with physical therapist students after their terminal acute care CEE. Qualitative analysis was approached from an interpretive epistemological perspective and a phenomenological approach was used to explore students' experience in participating in an online delivery mode to gain the required skills to be effective during acute care physical therapist practice. Data analysis was completed using a thematic analysis approach.

Outcomes:
Seven students participated in qualitative interviews after their acute care educational experience. Qualitative results revealed 3 main themes: (1) Course Design, (2) Fidelity, and (3) Learner Characteristics as contributors to feelings of preparedness when transitioning from the classroom to an acute care CEE.

Discussion and Conclusion:
Despite COVID-19 disruptions to traditional in-person education delivery of an acute care laboratory-based course, a unique at-home delivery of acute care curriculum led to students reporting sufficient skill development to participate in an acute care CEE. Aspects of the unique course that students reported facilitated their learning were skill repetition and fidelity to clinical practice embedded in laboratory activities. Results can be used to intentionally design coursework to aide in building student confidence and preparation for acute care CEE.
Cocaine-induced pyoderma gangrenosum with negative anti-neutrophil cytoplasmic antibodies: A case report
Authors: Lim Rachel K. , Negbenebor Nicole A. , Lin Erica M. , Ragi Sara D. , Robinson-Bostom Leslie , Massoud Cathy M. 
Published: August 2023

Introduction:
Cutaneous pyoderma gangrenosum (PG) is an ulcerating autoinflammatory neutrophilic dermatosis often associated with inflammatory bowel disease, hematologic diseases, or arthritis. PG secondary to systemic medications is less commonly reported. PG is a diagnosis of exclusion that requires investigation of other causes of cutaneous ulcers prior to final diagnosis.

Case presentation:
We herein describe a case of cocaine-induced PG with atypical features (recurrent ulcerations limited to the lower extremities and perinuclear anti-neutrophil cytoplasmic antibody negativity) following years of abstinence from cocaine.

Discussion:
PG is a rare autoinflammatory neutrophilic dermatosis and a diagnosis of exclusion because of its nonspecific clinical presentation. Drug-induced PG is less common but presents an opportunity to further research the pathogenesis of PG.

Conclusion:
This unusual case reinforces that drug-induced PG may have non-classical features and may serve as an indicator of past or present substance abuse, allowing for patient education and counseling.
Pembrolizumab-induced erosive lichenoid reaction in a patient with metastatic lung adenocarcinoma: A case report
Authors: Venturi Federico , Melotti Barbara , Lambertini Martina , Alessandrini Aurora , Ardizzoni Andrea , Dika Emi 
Published: August 2023

Introduction:
Immune-related adverse events induced by immune checkpoint inhibitors are quite common. Cutaneous lichenoid immune-related adverse events are among the most frequent. However, oral lichenoid adverse reactions are extremely rare.
We herein describe a patient who was treated with pembrolizumab for metastatic lung cancer and developed an erosive oral lichenoid reaction induced by immunotherapy.

Case presentation:
An 87-year-old man treated with pembrolizumab for metastatic lung adenocarcinoma (stage IVa based on AJCC 2018) developed multifocal erosions of the oral mucosa mainly located on the buccal mucosa, palate, and inner portion of the lips with multiple small, irregular, hyperkeratotic areas. Histopathological examination showed epithelial necrosis and a dense band-like layer of an inflammatory infiltrate of lymphocytes and histiocytes within the upper dermis. Direct immunofluorescence was negative for both IgG and C3. A diagnosis of erosive oral lichenoid reaction of the mucosa induced by immunotherapy was established. Given the severity of the condition, pembrolizumab treatment was withheld and concomitant topical and systemic steroids were started. After 1 month, the drug-related toxicity was ameliorated and immunotherapy was re-introduced.

Discussion:
Only one other case of pembrolizumab-induced erosive lichen planus of the oral mucosa has been described to date. Previously reported drug-induced lichenoid rashes were mainly localized on the skin. Clinically, the main differential diagnoses of lichenoid erosive lesions are bullous immune-related disorders and should be excluded. In our patient, histological examination combined with negative results of both direct immunofluorescence and enzyme-linked immunosorbent assays confirmed the diagnosis of erosive lichenoid drug reaction.

Conclusion:
Clinicians should be aware of lichenoid involvement of the oral mucosa because related pain and food intake difficulties may seriously compromise treatment compliance. Prompt treatment of oral drug-related reactions may prevent interruption of immunotherapy and improve patients’ quality of life.