bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convolutional neural network based object detection system for video surveillance application
Authors: Bhimavarapu John Philip , Ramaraju Sriharsha , Nagajyothi Dimmita , Rao Inumula Veeraraghava 
Published: December 2022

SummaryVideo surveillance is emerging as a promising solution for the humans to lead a peaceful and independent life in their homes. The recognition and localization of moving objects plays a central role in the video surveillance. The manual surveillance is time consuming and tedious. Therefore, novel object detection via optimized deep learning model is developed in this work that supports the video surveillance application. In the initial phase, proposed angle and distance based Local Binary Pattern (LBP) features are extracted. Subsequently, these extracted features are subjected to object detection phase, where optimized Convolutional Neural Network (CNN) will expose the information about the detected object. Further, the learning quality of CNN is decided by the weight parameter, which is responsible to distinguish the objects with high accuracy. Therefore, a hybrid optimization concept referred as Sealion Leader Update with Particles (SLUP) is introduced in this research work to fine‐tune the weight of CNN. Finally, a comparative analysis is made between the proposed and the extant approaches in terms of “positive, negative, and other measures.”
Social big data applications and challenges
Authors: Erol Salih Erdem , Aksoy Çağla , Sağıroğlu Şeref 
Published: December 2022

AbstractLifestyles of individuals have changed drastically in the last two decades with the impact of social media platforms which transforms individuals from being users into an asset of social media. The assets now become very precious and seriously attract who can generate useful or harmful values. In this context, studies conducted in the last 5 years are analyzed based on the methodology covering implementation areas, data sources, data size, methods and tools. The studies were classified and summarized under nine main “research fields,” and a “purpose‐based” classification under three main purposes was investigated. The results have shown that even if data obtained from social media platforms are often preferred in the studies, issues such as compliance with legal regulations, data processing, confidentiality and privacy of data also bring difficulties; collection and processing of social big data are a serious obstacle to the realization of many studies; not enough data sources provided by public or private enterprises; most of the studies carried out on text data, and the rest focused on location and image data; mostly machine learning methods are preferred in applications. This study differs from previous literature reviews by revealing comprehensively how social big data can be transformed into practice with a holistic perspective.
Sexual offense victims' responses to the question #WhyIDidntReport? Examining restorative justice as an alternative dispute resolution mechanism
Authors: Peleg‐Koriat Inbal , Klar‐Chalamish Carmit 
Published: December 2022

AbstractThe aim of the present study was to examine barriers to reporting sexual offenses as reflected in texts by victims who participated in the #WhyIDidntReport protest that revolved around the reasons for not reporting sexual offenses. Content analysis was used to analyze 95 public posts of Israeli victims published on social media. The findings revealed two main barrier dimensions—personal and social—each comprising several main themes. The most common barrier in the personal dimension was difficulty naming or labeling the experience as a sexual offense to begin with. The most prominent barriers in the social dimension were the power gap between offender and victim, and concern with others' reactions. We discuss the theoretical and practical implications of our findings from the perspectives of alternative dispute resolution, with focus on restorative justice as an optional platform for victims.
Multi‐omics integration reveals a core network involved in host defence and hyperkeratinization in psoriasis
Authors: Deng Jingwen , Leijten Emmerik , Nordkamp Michel Olde , Zheng Guangjuan , Pouw Juliëtte , Tao Weiyang , Hartgring Sarita , Balak Deepak , Rijken Rianne , Huang Runyue , Radstake Timothy , Lu Chuanjian , Pandit Aridaman 
Published: December 2022

AbstractObjectivesThe precise pathogenesis of psoriasis remains incompletely explored. We aimed to better understand the underlying mechanisms of psoriasis, using a systems biology approach based on transcriptomics and microbiome profiling.MethodsWe collected the skin tissue biopsies and swabs in both lesional and non‐lesional skin of 13 patients with psoriasis, 15 patients with psoriatic arthritis and healthy skin from 12 patients with ankylosing spondylitis. To study the similarities and differences in the molecular profiles between these three conditions, and the associations between the host defence and microbiota composition, we performed high‐throughput RNA‐sequencing to quantify the gene expression profile in tissues. The metagenomic composition of 16S on local skin sites was quantified by clustering amplicon sequences and counted into operational taxonomic units. We further analysed associations between the transcriptome and microbiome profiling.ResultsWe found that lesional and non‐lesional samples were remarkably different in terms of their transcriptome profiles. The functional annotation of differentially expressed genes showed a major enrichment in neutrophil activation. By using co‐expression gene networks, we identified a gene module that was associated with local psoriasis severity at the site of biopsy. From this module, we found a ‘core’ set of genes that was functionally involved in neutrophil activation, epidermal cell differentiation and response to bacteria. Skin microbiome analysis revealed that the abundances of Enhydrobacter, Micrococcus and Leptotrichia were significantly correlated with the genes in core network.ConclusionsWe identified a core gene network that associated with local disease severity and microbiome composition, involved in the inflammation and hyperkeratinization in psoriatic skin.
Blockchain‐based secure deduplication of encrypted data supporting client‐side semantically secure encryption without trusted third party
Authors: Qin Guiyun , Li Limin , Liu Pengtao , Hu Chengyu , Guo Shanqing 
Published: December 2022

AbstractTo accommodate the new demand for the deduplication of encrypted data, secure encrypted data deduplication technologies have been widely adopted by cloud service providers. At present, of particular concern is how deduplication can be applied to the ciphertexts encrypted by semantically secure symmetric encryption scheme. Avoiding disadvantages of the existing methods, in this article, we propose a blockchain‐based secure encrypted data deduplication protocol supporting client‐side semantically secure encryption. In the proposed protocol, the smart contracts are deployed by the first file uploader, and then the subsequent uploaders implement an interactive proof of ownership for the same file with the help of the smart contracts executing a cloud data integrity auditing protocol. The smart contracts play the role of the trusted third party and therefore make up for the poor feasibility for the existence of a trusted third party in real scenario. In addition, in the proposed protocol, there is no need for other clients who have uploaded the same file to be online to help the current uploader obtain the encryption key. We also prove its security and evaluate its performance.
Analysis of adolescents' perception and awareness level for Sexual and Reproductive Health Rights in Pakistan
Authors: Khan Muhammad Danyal , Daniyal Muhammad , Abid Khadijah , Tawiah Kassim , Tebha Sameer Saleem , Essar Mohammad Yasir 
Published: December 2022

AbstractBackgroundAwareness of rights is a precondition to establishing rule of law in society. Sexual and Reproductive Health and Rights (SRHR) are closely knitted in the human rights framework as they overlap with other human rights such as the right to health and life. However, awareness about these rights remains a challenge. Considering the importance of these rights this study has measured the awareness of adolescents about SRHR in Bahawalpur (Division) of Pakistan.MethodologyWe conducted a cross‐sectional study in the Divison of Bahawalpur, Pakistan from October 2019 to December 2019. The study included a sample size of 500 respondents which included 250 young females of age 15–19 and 250 their parents (mother). The reasoning behind including only females in this study was the increased vulnerability and greater impact of SRHR in their life compared to males. The age range 15–19 was primarily selected as females this age will better understand and respond to the questionnaire compared to females in their early adolescent years. The quantitative research was conducted using two‐stage cluster sampling. Detailed structured questionnaires were distributed among the respondents to obtain their points of view on the awareness of SRHR. The population was divided into multi‐clusters with 25 households comprising 250 households for the division of Bahawalpur. The information was also gathered from the doctors and the teachers through interviews. The data were analyzed using SPSS version 21.ResultsThe study explored the knowledge and understanding of adolescent SRHR thereby highlighting the key restrictions in Bahawalpur, Pakistan, which prohibit adolescents from gaining access to SRHR and exercising it. There is a significant portion of adolescents who strongly agreed with the importance and awareness level and think they should be more aware of information regarding SRHR. However, they are of the view that they are less independent in practicing them.ConclusionThe study found a low level of awareness about SRHR among young female and their parents in Bahawalpur, Pakistan. It is a need of time and responsibility of the local government of the Bahawalpur region to devise clear and proper policies which give access to these rights. This can be done by including the information on these rights in the course curriculum and teachers keeping in view the cultural and regional restrictions that guide the young female about SRHR.
Why do corporate social responsibility‐oriented companies opt for bond debt? Evidence from crisis periods
Authors: Abbassi Wajih , Boubaker Sabri , Louhichi Wael 
Published: December 2022

AbstractUsing a large panel of 19,208 listed companies across 40 countries, we investigate the relation between corporate social responsibility (CSR) and bond debt issuance through two main channels: information asymmetry and monitoring. The information asymmetry channel supports that CSR helps firms exhibit more transparency and thereby opt for bond debt. On the other side, the monitoring channel stipulates that CSR makes managers less inclined to engage in value‐diverting activity which makes worthless the scrutiny of banks' monitoring. Results hold after conducting a series of robustness tests and a cross‐sectional heterogeneity analysis at the country level. In addition, the positive relationship between CSR and bond debt is tested in the pre‐ during‐ and post‐ global financial crisis. The relation is more pronounced (i) during periods of uncertainty, (ii) for countries with better informational environment and (iii) for countries with higher levels of agency costs. Overall, our findings are of interest to managers, investors, and policymakers as they show the benefits of CSR commitment during crisis periods marked by a strong need for trust and for more responsible finance.
Laparoscopic redo pyeloplasty with a buccal mucosal graft
Authors: Shimizu Nobuhiko , Naya Yukio , Sekine Keita , Hou Kyokushin , Okato Atsushi , Suyama Takahito , Araki Kazuhiro , Masuda Hiroshi , Kojima Satoko 
Published: December 2022

IntroductionRedo pyeloplasty can be difficult due to scar tissue or fibrosis. Ureteral reconstruction with a buccal mucosal graft is performed safely and successfully, but most reports of ureteral reconstruction using a buccal mucosal graft are of robot‐assisted surgery, with few reports of laparoscopic‐assisted surgery. A case of laparoscopic‐assisted redo pyeloplasty using a buccal mucosal graft is presented.Case presentationA 53‐year‐old woman was diagnosed with ureteropelvic junction obstruction, and a double‐J stent was placed to relieve backache. She visited our hospital 6 months after double‐J stent placement. Three months later, laparoscopic pyeloplasty was performed. At 2 months postoperatively, anatomic stenosis occurred. Holmium laser endoureterotomy and balloon dilation were performed; however, the anatomic stenosis recurred, and laparoscopic redo pyeloplasty with a buccal mucosal graft was performed. After redo pyeloplasty, obstruction was improved, and her symptoms disappeared.ConclusionThis is the first case of using a buccal mucosal graft for laparoscopic pyeloplasty in Japan.
Circ_0000284 upregulates RHPN2 to facilitate pancreatic cancer proliferation, metastasis, and angiogenesis through sponging miR‐1179
Authors: Zhang Jian , Li Jiangwei , Xiong Yongqiang , Li Ren 
Published: December 2022

AbstractBackgroundCircular RNA (circRNA) has been confirmed to be a key regulator for pancreatic cancer (PC) progression, but the role of circ_0000284 in PC development remains unclear.MethodsQuantitative real‐time PCR was used to measure the expression of circ_0000284, microRNA (miR)‐1179, and rhophilin 2 (RHPN2). PC cell proliferation, metastasis, angiogenesis, and apoptosis were assessed by EdU assay, transwell assay, tube formation assay, and flow cytometry. Relative protein expression was determined by western blot analysis. The interaction between miR‐1179 and circ_0000284 or RHPN2 was confirmed by dual‐luciferase reporter assay and RNA pull‐down assay.ResultsCirc_0000284 was significantly upregulated in PC tissues and cells, and its knockdown inhibited PC cell proliferation, migration, invasion, and angiogenesis while promoting apoptosis. MiR‐1179 was downregulated in PC tissues and cells, and it could be sponged by circ_0000284. Moreover, the miR‐1179 inhibitor reversed the regulation of circ_0000284 knockdown on PC cell progression. The highly expressed RHPN2 was found in PC tissues and cells, and it could be targeted by miR‐1179. Also, circ_0000284 sponged miR‐1179 to regulate RHPN2 expression. Overexpressed RHPN2 could reverse the regulation of circ_0000284 knockdown on PC cell progression. In addition, interference of circ_0000284 was discovered to repress PC tumor growth by regulating miR‐1179/RHPN2.RHPN2.ConclusionTo sum up, our data confirmed that circ_0000284 facilitated PC malignant progression depending on the regulation of miR‐1179/RHPN2 axis, suggesting that circ_0000284 might be a potential target for PC treatment.
Predicting the prognosis of esophageal cancer based on extensive analysis of new inflammatory response‐related signature
Authors: He Hongbo , Zhang Peng , Li Feng , Zeng Cheng , Liu Donglei , Wu Kai 
Published: December 2022

AbstractThe prognosis of esophageal cancer (ESCA) is very poor, with a 5‐year survival rate of less than 20%. On the other hand, inflammation is the characteristic hallmark of ESCA; however, the prognostic relationship between inflammatory response‐related genes and ESCA has not been clarified yet. Therefore, in the present manuscript, we intend to investigate the correlation and specific signature of inflammation for the prediction of the prognosis of ESCA. A total of 173 samples were obtained from The Cancer Genome Atlas (TCGA) database, including 162 tumors and 11 normal specimens. The prognostic signature was established by least absolute shrinkage and selection operator Cox regression analysis. The transcription factor regulatory network with genes of the prognostic signature was analyzed from the transcriptional regulatory relationships unravelled by sentence‐based text‐mining database. Chemotherapy sensitivity and immunotherapy analysis were also performed. Multivariate Cox analysis showed that the signature was an independent prognostic risk factor. The low‐risk group had poorer outcomes than the high‐risk group. In the high‐risk group, the infiltration of most immune cells was high and strongly correlated with the riskScore. In chemotherapeutic drug sensitivity analysis, OSM, AHR, and BTG2 were significantly correlated with the current chemotherapeutic drugs of ESCA. We have demonstrated a valid prognostic signature of inflammatory response‐related genes and found strong associations with immune cells, targeted genes, and chemotherapeutic agents.
Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells
Authors: Mumtaz Noreen , Dudakovic Amel , Nair Asha , Koedam Marijke , van Leeuwen Johannes P. T. M. , Koopmans Marion P. G. , Rockx Barry , van Wijnen Andre J. , van der Eerden Bram C. J. 
Published: December 2022

AbstractArboviruses target bone forming osteoblasts and perturb bone remodeling via paracrine factors. We previously reported that Zika virus (ZIKV) infection of early‐stage human mesenchymal stromal cells (MSCs) inhibited the osteogenic lineage commitment of MSCs. To understand the physiological interplay between bone development and ZIKV pathogenesis, we employed a primary in vitro model to examine the biological responses of MSCs to ZIKV infection at different stages of osteogenesis. Precommitted MSCs were infected at the late stage of osteogenic stimulation (Day 7) with ZIKV (multiplicity of infection of 5). We observe that MSCs infected at the late stage of differentiation are highly susceptible to ZIKV infection similar to previous observations with early stage infected MSCs (Day 0). However, in contrast to ZIKV infection at the early stage of differentiation, infection at a later stage significantly elevates the key osteogenic markers and calcium content. Comparative RNA sequencing (RNA‐seq) of early and late stage infected MSCs reveals that ZIKV infection alters the mRNA transcriptome during osteogenic induction of MSCs (1251 genes). ZIKV infection provokes a robust antiviral response at both stages of osteogenic differentiation as reflected by the upregulation of interferon responsive genes (n > 140). ZIKV infection enhances the expression of immune‐related genes in early stage MSCs while increasing cell cycle genes in late stage MSCs. Remarkably, ZIKA infection in early stage MSCs also activates lipid metabolism‐related pathways. In conclusion, ZIKV infection has differentiation stage‐dependent effects on MSCs and this mechanistic understanding may permit the development of new therapeutic or preventative measures for bone‐related effects of ZIKV infection.
A nomogram and risk classification system predicting esophageal stricture after endoscopic submucosal dissection of a large area for early esophageal cancer
Authors: Li Xue , Xing Jie , Li Peng , Xie Sian , Lin Qianyun , Zhang Qian , Zhang Shutian 
Published: December 2022

AbstractBackground and ObjectivesEsophageal stricture is a troublesome adverse effect of endoscopic submucosal dissection (ESD) for early esophageal cancer. However, risk factors of post‐ESD esophageal stricture formation are incomprehensive. This study aimed to conduct a comprehensive analysis of independent risk factors and provide predictive tools.MethodsPatients who underwent ESD for early esophageal cancer between 2014 and 2021 at the Beijing Friendship Hospital, Capital Medical University, were recruited. A nomogram and risk classification system was established based on Cox proportional hazards analyses and validated using the concordance index (C‐index), calibration curves, decision curve analysis (DCA), and Kaplan–Meier (K–M) curves.ResultsStricture formed in 36 patients, while stricture was not observed in the remaining 112 patients. Operative time (odds ratio [OR]: 1.01; 95% confidence interval [CI]: 1.00–1.01; p < 0.01); lesions >3/4 circumferential range of esophagus (OR: 3.82; 95% CI: 1.90–7.66; p < 0.01), and tumor infiltration to the mucosal lamina propria (m2) or deeper (OR: 2.40; 95% CI: 1.24–4.66; p = 0.01) were independent predictive factors for post‐ESD esophageal stricture. The nomogram and risk classification system was developed and validated with 0.79 C‐index, good calibration curves, good DCA results, and good K–M curves.ConclusionsWe developed a nomogram and risk stratification system to predict post‐ESD esophageal stricture using three independent risk factors.
A Two‐Stage Method for Adult Congenital Microtia: The Essentials of 15‐Year Experience
Authors: Li Hanbo , Wang Yue , Qian Jin , Wang Bingqing , Liu Tun , Zhang Qingguo 
Published: December 2022

HypothesisTreatment of congenital microtia in adults remains challenging due to the unique physiological characteristics of the costal cartilages and retroauricular skin, which interfere with obtaining a satisfactory aesthetic result; thus, different perspectives and technical modifications during treatment are warranted. This article aims to present complementary new information and essential tips to refine the surgical technique in adult microtia reconstruction.MethodsA total of 346 adult microtia patients underwent surgical intervention at the Auricular Reconstruction Center of Plastic Surgery Hospital (Beijing, China) between 2006 and 2021. Each patient underwent a rigorous preoperative evaluation and stages one and two surgeries.ResultsPatients were followed in our clinic for 6 months to 10 years (average: 15.3 months). The postoperative complication rate was 8.1%, which included cartilage exposure, broken helix, local hematoma, infection, poor skin graft survival, and scar hypertrophy.ConclusionsOur results showed that the two‐stage treatment strategy for adults is versatile, reliable, and effective for the treatment of congenital microtia.Level of Evidence4 Laryngoscope, 133:2148–2153, 2023
Self‐care in coronary heart disease patient and caregiver dyads (HEARTS‐IN‐DYADS)—Protocol of a multicenter longitudinal study
Authors: Simonelli Niccolò , Bolgeo Tatiana , Iovino Paolo , Di Matteo Roberta , Maconi Antonio , Vellone Ercole 
Published: December 2022

AbstractSelf‐care performed by patients and the caregiver contribution to this self‐care are essential for improving cardiovascular outcomes; however, so far, no studies have sufficiently investigated this field in Italy. This paper describes a research protocol of a multi‐center longitudinal study designed to investigate the self‐care of patients affected by coronary heart disease (CHD), the caregiver's contribution to this self‐care, the predictors of patient and caregiver self‐care, the mediating role of self‐efficacy, and the self‐care outcomes. Data collection will be performed across seven Italian inpatient settings at baseline and 3 and 6 months from enrollment. Multilevel modeling and actor partner interdependence models will be implemented on a sample of 330 patient–caregiver dyads to adjust for the interdependence of measurements. The study received approval from an ethics committee in Italy and was financed in January 2021 by a grant from the Solidal Foundation in Alessandria. This research will advance the knowledge about the self‐care process in CHD. The results will guide research and clinical practice by identifying variables sensitive to educational interventions.