bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability of intra-atrial ECG method of insertion of central venous line through right internal jugular vein when compared to formula and radiological landmark method: a prospective randomized study
Authors: Kamath Manjunatha R. , Tiku Sakshi , Gopalakrishnan M. , Kiran Amith 
Published: August 2023

Abstract
Background
Ideal position of central venous catheter tip should be within 2 cm above and 1 cm below superior vena cava–right atrium (SVC-RA) junction. The objective of the study was to compare intra-atrial ECG method of Central venous catheterization of right internal jugular vein (IJV) with traditional methods. A prospective randomized trial enrolling 90 patients were alternatively allocated to three groups and comparison of intra-atrial electrocardiography, radiological landmark and Pere’s formula method for correct positioning of central venous catheter tip were done and tip position were confirmed with post-procedural TEE (transesophageal echocardiography).

Results
Catheter tip was present at the ideal position in 100% cases in intra-atrial ECG method compared to only 23.4% in formula method and 93.3% in landmark method (p value 0.001). In intra-atrial method group, the central venous catheter tip was placed perfectly in all patients, position of the catheter tip was not acceptable in 71.4% of the patients where formula method is used and not acceptable in 11.1% when landmark method is used (p value 0.001). However, we did not encounter any catheter related complications in any of these groups.

Conclusions
Intra-atrial ECG method carries the advantage of ideal positioning of the central venous catheter tip by right IJV route in almost all cases when compared to conventional formula and landmark method to some extent. Also, immediate confirmation and real time verification of central venous catheter (CVC) tip is possible, thereby avoids the need for post-procedural chest X-ray and other methods of central venous placement confirmation like arterial blood gas analysis etc., Hence, intra-atrial ECG method is cost effective and safer for confirmation of CVC tip in all the situations.
Evaluation of beta-blocker effects on patients with traumatic brain injury: interventional double-blinded randomized controlled trial
Authors: Mansour Mostafa Saieed , Seidy Nihal Shahat El , Fathey Yasser Ibrahim 
Published: August 2023

Abstract
Background
Traumatic brain injury (TBI) is a major cause of death and disability throughout the world. Traumatic injury is one of the most common causes of death in people under the age of 40 worldwide, and one-third of all trauma-related deaths are a result of intracranial insults. We aimed to conduct a randomized controlled trial examining the effect of beta-blockers on outcomes in TBI patients.

Result
Regarding CT brain, 45% of cases in the beta-blocker group and 60% of cases in the control group had abnormal CT findings. Contusion and brain edema were still observed in the beta-blocker group (5% in each), while hemorrhage was still found in 35% of cases in the beta-blocker group and 55% of cases in the control group. Furthermore, a fractured skull was observed in 5% of cases in the beta-blocker group and 20% of cases in the control group. No significant differences were found between the two groups regarding CT brain findings (p-value was > 0.05).
Mortality was 15% in the beta-blocker group and 30% in the control group, while 95% of patients in the beta-blocker group and 90% of patients in the control group had ICU stay ≤ 14 days.

Conclusions
Total hospital stay > 14 days showed a significant rise in the beta control group when compared to the blocker group while no significant differences between them in survival, ICU stay, total hospital stay, and total hospital length of stay for patients stayed ≤ 14. Patients in the beta-blocker group showed no significant differences in overall survival compared to patients in the control group.

Trial registration
ClinicalTrials.gov ID: NCT05195996.
Evaluating change in a pressured healthcare system: a cross-sectional study of implementation outcomes using routine data indicators and proxies
Authors: Hanbury Andria , Mafirakureva Nyasha , Chicken Nicola , Bailey Liam 
Published: August 2023

Abstract
Background
Implementation evaluation should focus on implementation success, guided by theories and frameworks. With high staff vacancies in the health services, it is important to consider pragmatic methods of data collection for implementation evaluation. This paper presents a cross-sectional rapid evaluation of a handheld medical device designed for remote examinations, piloted in Northern England. By using downloaded device data and administrative records mapped to domains from the implementation outcomes framework, this evaluation offers a pragmatic example of assessing implementation success.

Methods
The pilot design was pragmatic: sites volunteered, decided which services to use the device in, and launched when ready. The pilot and evaluation together lasted 1 year. Data was downloaded from the devices, and administrative records for the pilot accessed. Variables were mapped to five of the implementation outcomes, after reviewing with the device manufacturer and pilot team to assess robustness.

Results
N=352 care episodes were recorded using the device with 223 patients. Out of 19 sites ‘signed up’ to the pilot, 5 launched and delivered 10 of 35 proposed projects: a site and project adoption rate of 26 and 29%, respectively. Six sites signed up to an extension period; three had launched and three had not during the original timelines, indicating some sustainability. Feasibility was high, with only one in seven care episodes needing to be repeated due to poor device quality or error (sound/audio/internet). Fidelity of device usage was low for two of the eight available device examinations. Device and staffing costs were high but potential cost savings were attributable to fewer in-person appointments.

Conclusions
Through using device and administrative data, this evaluation minimised burden on busy healthcare staff yet was still guided by an evaluation framework. Five out of the eight implementation outcomes were measured, including sustainability and costs. The findings give insight into implementation challenges, particularly around adoption. For future research, it is recommended to engage with staff to prioritise outcome measurements and to focus on meaningful interpretation of indicators.
Harnessing disordered photonics via multi-task learning towards intelligent four-dimensional light field sensors
Authors: Zhu Sheng-ke , Zheng Ze-huan , Meng Weijia , Chang Shan-shan , Tan Yingling , Chen Lu-Jian , Fang Xinyuan , Gu Min , Chen Jin-hui 
Published: August 2023

AbstractThe complete description of a continuous-wave light field includes its four fundamental properties: wavelength, polarization, phase and amplitude. However, the simultaneous measurement of a multi-dimensional light field of such four degrees of freedom is challenging in conventional optical systems requiring a cascade of dispersive and polarization elements. In this work, we demonstrate a disordered-photonics-assisted intelligent four-dimensional light field sensor. This is achieved by discovering that the speckle patterns, generated from light scattering in a disordered medium, are intrinsically sensitive to a high-dimension light field given their high structural degrees of freedom. Further, the multi-task-learning deep neural network is leveraged to process the single-shot light-field-encoded speckle images free from any prior knowledge of the complex disordered structures and realizes the high-accuracy recognition of full-Stokes vector, multiple orbital angular momentum (OAM), wavelength and power. The proof-of-concept study shows that the states space of four-dimensional light field spanning as high as 1680=4 (multiple-OAM) $$\times$$
×
2 (OAM power spectra) $$\times$$
×
15 (multiple-wavelength) $$\times$$
×
14 (polarizations) can be well recognized with high accuracy in the chip-integrated sensor. Our work provides a novel paradigm for the design of optical sensors for high-dimension light fields, which can be widely applied in optical communication, holography, and imaging.
Giant cell carcinoma of the lung with hypertrophic pulmonary osteoarthropathy as a paraneoplastic syndrome: a case report
Authors: Sobue Akimu , Mizobuchi Teruaki , Ishibashi Fumihiro , Nagato Kaoru , Imabayashi Hiroki , Ishida Yasuo , Sugano Isamu 
Published: August 2023

Abstract
Background
Hypertrophic pulmonary osteoarthropathy is a rare syndrome characterized by a triad that includes periostitis, digital clubbing, and painful arthropathy of the large joints, especially large joints in the lower limbs with lung cancer. Herein we describe a case of a giant cell carcinoma of the lung with hypertrophic pulmonary osteoarthropathy as a paraneoplastic syndrome. The tumor was successfully resected, and complete remission of the syndrome was achieved after surgery.

Case presentation
A 48-year-old man with right fingers and bilateral ankle arthralgias was referred to our hospital. These arthropathies were painful and refractory to the oral administration of several non-steroidal anti-inflammatory drugs; thus, oxycodone hydrochloride hydrate was prescribed. Additionally, the fingers and toes had a clubbed appearance and the tubular bones were shown as double lines on radiographs of both arms and legs, indicating periosteal thickening. A 45-mm mass-like shadow was present on the right upper-to-middle lung field on the chest x-ray, which was confirmed to be a mass in the upper lobe of the right lung on the chest CT scan. An abnormal uptake was observed in the area of the mass on the FDG-PET scan; the standardized uptake value maximum was 11.8. The histologic diagnosis of a bronchoscopic biopsy was an undifferentiated carcinoma, and the clinical diagnosis was non-small cell lung cancer. The clinical stage was c-T2bN0M0 with paraneoplastic syndrome as a hypertrophic pulmonary osteoarthropathy. A right upper lobectomy with an S6 partial resection adjacent to the upper lobe of the right lung and an ND2a-2 lymph node dissection was performed. The postoperative course was uneventful. The pathologic diagnosis was a giant cell lung carcinoma, which was classified as p-T3 (52 mm in diameter) N0M0, stageIIB. A gradual decrease in arthritic pain was observed from the first operative day. No anodyne, including oxycodone, was required approximately 2 months after surgery. No tumor or paraneoplastic syndrome recurrence was observed 2 years postoperatively.

Conclusions
Hypertrophic pulmonary osteoarthritis may occur as a secondary manifestation of lung malignancies. Thus, the paraneoplastic syndrome should be considered in such cases.
Murakami Haruki's Postmemory of the Asia-Pacific War
Authors: Abe Kodai 
Published: August 2023

AbstractThis article shows how Murakami Haruki's novel The Wind-Up Bird Chronicle (1994–95) constructs a historical narrative to overcome the victim/perpetrator dichotomy and demands ethical response from readers. Drawing on Marianne Hirsch's term postmemory, the author analyzes the novel as a postmemory generation's struggle over the question of how postmemory generations of a former perpetrator country would be able to ethically respond to a temporally distanced, shameful, and traumatic past. Murakami's postmemory protagonist archives scattered pieces of the wartime and postwar pasts narrated by directly traumatized others and constructs a historical narrative to critically overcome the victim/perpetrator dichotomy that regulates the discourse surrounding wartime Japan's violent history. By having his nonviolent protagonist assume a violent aspect and turn into a perpetrator, the author argues, Murakami demands an ethical response from contemporary readers, that is, not simply understanding historical violence as a past to be criticized but imagining it as “our” own, ongoing problem.
Rapid Implementation of a 3-Dimensional–Printed Patient-Specific Titanium Sacrum Implant for Severe Neuropathic Spinal Arthropathy and Guide to Compassionate US Regulatory Approval
Authors: Ruiz-Cardozo Miguel A. , Trevino Gabriel , Pando Alejandro , Brehm Samuel , Olufawo Michael , Barot Karma , Carey-Ewend Abigail , Yahanda Alexander T. , Perdomo-Pantoja Alexander , Jauregui Julio J. , Cadieux Magalie , Costa Megan , Coenen Julie , Dorward Ian , Anolik Rachel A. , Sacks Justin M. , Molina Camilo A. 
Published: August 2023

BACKGROUND AND OBJECTIVE:
Rapid design and production of patient-specific 3-dimensional–printed implants (3DPIs) present a novel opportunity to restore the biomechanically demanding integrity of the lumbopelvic junction. We present a unique case of a 61-year-old patient with severe neuropathic spinal arthropathy (Charcot spine) who initially underwent a T4-to-sacrum spinal fusion. Massive bone destruction led to dissociation of his upper body from his pelvis and legs. Reconstruction of the spinopelvic continuity was planned with the aid of a personalized lumbosacral 3DPI.

METHOD:
Using high-resolution computed tomography scans, the custom 3DPI was made using additive titanium manufacturing. The unique 3DPI consisted of (1) a sacral platform with iliac screws, (2) modular corpectomy device with rigid connection to the sacral platform, and (3) anterior plate connection with screws for proximal fixation. The procedures to obtain compassionate use Food and Drug Administration approval were followed. The patient underwent debridement of a chronically open wound before undertaking the 3-stage reconstructive procedure. The custom 3DPI and additional instrumentation were inserted as part of a salvage rebuilding procedure.

RESULTS:
The chronology of the rapid implementation of the personalized sacral 3DPI from decision, design, manufacturing, Food and Drug Administration approval, and surgical execution lasted 28 days. The prosthesis was positioned in the defect according to the expected anatomic planes and secured using a screw–rod system and a vascularized fibular bone strut graft. The prosthesis provided an ideal repair of the lumbosacral junction and pelvic ring by merging spinal pelvic fixation, posterior pelvic ring fixation, and anterior spinal column fixation.

CONCLUSION:
To the best of our knowledge, this is the first case of a multilevel lumbar, sacral, and sacropelvic neuropathic (Charcot) spine reconstruction using a 3DPI sacral prosthesis. As the prevalence of severe spine deformities continues to increase, adoption of 3DPIs is becoming more relevant to offer personalized treatment for complex deformities.
Alkali Metal Carboxylates: Simple, Efficient, and Industrial Relevant Catalysts for Controlled Polymer Synthesis
Authors: Li Feng , Suzuki Ryota , Gao Tianle , Xia Xiaochao , Isono Takuya , Satoh Toshifumi 
Published: August 2023

Abstract
Polymer materials play a pivotal role in shaping modern society. The continuous development of polymer materials can be largely attributed to innovations in polymerization methods, especially in the development of new catalysts. When pursuing high-performance catalysts, it is crucial to consider their cost and safety for practical applications. Alkali metal carboxylates (AMCs) are widely available simple chemicals, and some of them are used as food additives. In the past few years, our group has demonstrated the ability of such simple compounds to catalyze the ring-opening polymerization of cyclic esters, cyclic carbonates, epoxides, and episulfides. Additionally, AMCs have demonstrated their efficacy in facilitating the ring-opening alternating copolymerization of cyclic anhydrides and cyclic ethers, resulting in the production of polyesters in a well-controlled manner. Moreover, AMCs can also catalyze the complicated self-switchable polymerization of a mixture of at least three monomers, yielding block copolymers with well-controlled block components and architectures. This account summarizes these successful examples, offering mechanistic insights and an outlook.
Predicting systemic lupus erithematosus disease activity index 2000 (Sledai 2k) score after pulse dose metyl prednisolone in severe systemic lupus erithematosus
Authors: Paramaiswari Ayu , Kertia Nyoman , Intansari Umi , Nugroho Dhite Bayu 
Published: August 2023

Background: Systemic lupus erythematosus (SLE) is a chronic multisystem rheumatic disease characterized by developing autoantibodies against nucleus antigen. It has a broad range of clinical symptoms and the potential to affect nearly all organs and tissues. Pulse dosage methylprednisolone (MEP) is the immunosuppression modality for life-threatening or organ-threatening SLE. However, it is challenging to estimate the MEP response rate. We combine clinical symptoms, routine laboratory examinations, and more specific protein examinations such as soluble B-cell activating factor (sBAFF), B-cell activating factor receptor (BAFF-R), and Interferon gamma-induced protein 10 (IP-10) to develop a formula that can predict the SLE Disease Activity Index 2K (SLEDAI 2K) score following a pulse dosage of methylprednisolone. Methods: In a prospective cohort study, patients with severe SLE with a SLEDAI 2K score of 12 or Lupus nephritis class III or IV according to WHO criteria were given methylprednisolone 500 mg/day for three consecutive days. Enzyme-linked immunosorbent assay (ELISA) tested blood samples for soluble (s) BAFF, IP 10, and flow cytometry for BAFF-R, CD-19. The SLEDAI 2K score was reevaluated after a pulse dose of methylprednisolone was administered. All statistical analyses were conducted using the Rstudio program. Results: Overall, 80 patients were included. Multivariate multiple regression analysis revealed that urine protein creatinine ratio (UPCR) (x1), CD19 percentage (x2), serum BAFF (x3), vasculitis (x4), and rash (x5) taken before MEP pulse were predictors for SLEDAI 2k score after pulse dose methylprednisolone in severe SLE with the formula 13.41+ (0.0008542 * x1) + -0.1829338 * x2) + (0.0008776 * x3) + (7.1801728 * x4) + (7.5429676 * x6). Conclusions: Formula to predict SLEDAI 2k score after MEP pulse was 13.41+ (0.0008542 * x1) + -0.1829338 * x2) + (0.0008776 * x3) + (7.1801728 * x4) + (7.5429676 * x6). Further validation is needed to be used in clinical practice.
Fast Then Slow: Choice Revisions Drive a Decline in the Attraction Effect
Authors: Crosetto Paolo , Gaudeul Alexia 
Published: August 2023

We explore the nature and robustness of the attraction effect. The attraction effect can be seen as a persistent bias or as the result of heuristics that may not persist upon reflection. We provide robust experimental evidence that the attraction effect first rises and then falls over time when participants are incentivized to make a quick choice they can later revise. Participants in two experiments under continuous time pressure make choices among options with the aim to maximize an objective, measurable value. We find that participants disproportionately favor the asymmetrically dominant option in the first seconds and then revise their choices until the effect disappears or is significantly reduced. The effect survives only in the special and often studied case of indifference among options. We develop a tractable extension to the multiattribute linear ballistic accumulator model to allow for choice revisions. That model explains how choice revisions reduce context effects. We estimate its parameters at the individual level and document differences between fast and slow participants that also play a role in explaining the rise-and-fall pattern in the attraction effect. We extend the analysis to similarity and compromise effects. We find a very small similarity effect, which does not exhibit any dynamics, and a significant reverse compromise effect displaying a rise-and-fall pattern. Our findings, although limited to objective-value tasks, are consistent with context effects being short-term heuristics that can be superseded by more reflective cognitive strategies when decision makers have time and incentive to do so. This paper was accepted by Manel Baucells, behavioral economics and decision analysis. Funding: This work was supported by the Institut National de la Recherche Agronomique [Grant SAE2 Jeune Chercheur 2017]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4874 .
Sustainability Implications of Supply Chain Responsiveness
Authors: Tuna Ali Kaan , Swinney Robert 
Published: August 2023

Problem definition: A critical decision made by firms is whether to adopt a responsive supply chain (prioritizing speed) or an efficient supply chain (prioritizing cost). We consider the environmental implications of this choice, distinguishing between responsiveness achieved via three pathways: responsive offshore supply chains increase speed by using expedited production and distribution methods; responsive nearshore supply chains increase speed by reducing the physical distance between source and destination for all production; and hybrid nearshore supply chains produce in multiple locations simultaneously, increasing speed by reducing distance on some portion of production. Methodology/results: Using a model wherein responsiveness increases fixed and marginal costs, decreases leadtimes, and changes the per-unit environmental impact of production and distribution, we identify several results. First, all types of responsiveness can decrease environmental impact relative to an efficient supply chain, showing any form of responsiveness has potential to improve sustainability. Second, despite this, all types of responsiveness can also increase environmental impact relative to an efficient supply chain, particularly if demand variability is high. This is precisely when responsiveness is most profitable to the firm, indicating a tension between firm and environmental preferences. Third, a win-win outcome in which responsiveness both maximizes firm profit and minimizes environmental impact is most likely to occur when demand variability is high and unsatisfied customers substitute with a product that generates high environmental impact. Fourth, the firm may have incentive to choose a supply chain that does not minimize (and may maximize) environmental impact, especially at low-to-moderate demand variability. Managerial implications: While responsive supply chains can improve sustainability, they also generate the potential for misalignment of profit and environmental performance. We discuss the implications of this for firms and for policymakers seeking to encourage firms to use supply chains that generate the least environmental impact. Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2022.0152 .