bluuebunny/crossref_metadata_2025_split huggingface dataset:
WSES consensus guidelines on sigmoid volvulus management
Authors: Tian Brian W. C. A. , Vigutto Gabriele , Tan Edward , van Goor Harry , Bendinelli Cino , Abu-Zidan Fikri , Ivatury Rao , Sakakushev Boris , Di Carlo Isidoro , Sganga Gabriele , Maier Ronald V. , Coimbra Raul , Leppäniemi Ari , Litvin Andrey , Damaskos Dimitrios , Broek Richard Ten , Biffl Walter , Di Saverio Salomone , De Simone Belinda , Ceresoli Marco , Picetti Edoardo , Galante Joseph , Tebala Giovanni D. , Beka Solomon Gurmu , Bonavina Luigi , Cui Yunfeng , Khan Jim , Cicuttin Enrico , Amico Francesco , Kenji Inaba , Hecker Andreas , Ansaloni Luca , Sartelli Massimo , Moore Ernest E. , Kluger Yoram , Testini Mario , Weber Dieter , Agnoletti Vanni , Angelis Nicola De’ , Coccolini Federico , Sall Ibrahima , Catena Fausto 
Published: May 2023

AbstractSigmoid volvulus is a common surgical emergency, especially in elderly patients. Patients can present with a wide range of clinical states: from asymptomatic, to frank peritonitis secondary to colonic perforation. These patients generally need urgent treatment, be it endoscopic decompression of the colon or an upfront colectomy. The World Society of Emergency Surgery united a worldwide group of international experts to review the current evidence and propose a consensus guidelines on the management of sigmoid volvulus.
Identification and validation of m5c-related lncRNA risk model for ovarian cancer
Authors: Wang Chong , Zhang Chunxiao , Yang Shimin , Xiang Jiangdong , Zhou Dongmei , Xi Xiaowei 
Published: May 2023

AbstractOvarian cancer (OC) is one of the common malignant tumors that seriously threaten women's health, and there is a lack of clinical prognostic predictors, while m5c and lncRNA have been shown to be predictive of multiple cancers, including OC. Therefore, our goal was to construct a risk model for OC based on m5c-related lncRNA.340 m5c-related lncRNA were identified and a novel risk model of OC ground on nine m5C-related lncRNA was constructed using LASSO-COX regression analysis. Kaplan–Meier analysis showed there was a significant difference in prognosis between risk groups. We established a nomogram which was a good predictor of overall survival. In addition, GSEA was enriched in multiple pathways and immune function analysis suggested that immune infiltration varies depending on the risk group. In vitro experiments show that AC005562.1, a key lncRNA of the risk model, is highly expressed in OC cells and promotes OC cell proliferation. Finally, we further explored the potential biological markers of m5c-related lncRNA in OC with WGCNA analysis and established a ceRNA network. In conclusion,we have developed a reliable m5c-related prediction model and performed systematic validation and exploration of various aspects. These results can be used for the assessment of OC prognosis and the discovery of novel biomarkers.
Prevalence and risk factors of hypertension among public servants in Ejisu-Juaben municipality, Ghana
Authors: Agyemang-Pambour Bernice , Osei Isaac , Boateng-Osei Estella Antoinette , Kwarteng Alexander , Dzomeku Veronica 
Published: May 2023

Abstract
Objectives
We determined the prevalence and risk factors of hypertension among public servants of Ejisu Juaben municipality.

Results
The overall prevalence of hypertension was 29.3% (95%CI:22.5–36.1%) and only 8.6% of the participants were aware of their hypertensive status. Respondents who were > 40 years were twice as likely to develop hypertension compared to those who were ≤ 40 years [adjusted odds ratio (AOR) = 2.37, 95% confidence interval (CI) 1.05–5.32]. Those who were married were 2.54 times more likely to be hypertensive compared with those unmarried [AOR = 2.54, 95%CI: 1.06–6.08]. Compared to health workers, Judicial and Security service workers were almost five times more likely to be hypertensive [AOR = 4.77, 95%CI: 1.20–18.96]. Being overweight [AOR = 2.25, 95%CI: 1.06–6.41] and obese [AOR = 4.80, 95%CI: 1.82–12.91] was associated with increased odds of hypertension. The prevalence of hypertension among the participants in this study is high. Employee wellness programs are needed at workplaces and the Ghana Health Service must adopt targeted intervention programs such as regular screening for non-communicable diseases and promotion of physical activities at the workplace.
Metastasis of spine from adenoid cystic carcinoma of the parotid gland: two case reports
Authors: Safaei Saeid , Azimi Parisa , Yazdanian Taravat 
Published: May 2023

Abstract
Background
Spinal metastasis from adenoid cystic carcinoma of the salivary gland is extremely rare. We present two interesting cases of spinal metastasis from adenoid cystic carcinoma of the parotid gland.

Case summary
A 29-year-old Persian male and a 48-year-old Persian female presented with parotid gland mass. The two patients received parotidectomy and radiotherapy. The pathological examination result was adenoid cystic carcinoma. Because of intractable back pain, patients were referred to the hospital after 7 years and 9 months, respectively. Both cases underwent spinal surgery. Histopathology confirmed spinal metastasis from adenoid cystic carcinoma of the parotid gland (case 1: T6, T12, and L1; case 2: T12). Anterior corpectomy of T12 and lateral screw fixation at T11 and L1 were done in case 2. Posterior spinal fusions from T2 to L3 and from T10 to L2 were performed in case 1 and case 2, respectively. Both patients showed good clinical improvement. The last follow-up (case 1: 24 months; case 2: 6 months after surgery), plain radiographs and computed tomography scan showed good fusion without instrumental failure and magnetic resonance imaging revealed good decompression of the spinal cord of both cases.

Conclusion
Although spinal metastasis from adenoid cystic carcinoma of the parotid gland is extremely rare, it is necessary to be careful in the differential diagnosis.
Expression of microRNAs in leukocytes and serum of asbestosis patients
Authors: Kauschke Vivien , Philipp-Gehlhaar Monika , Schneider Joachim 
Published: May 2023

Abstract
Background
Although asbestos use is banned in many countries, long latency of asbestos-related diseases like pleural plaques or asbestosis mean it is still a public health issue. People suffering from these diseases have a higher risk of developing mesothelioma or lung cancer, which can progress quickly and aggressively. MicroRNAs were suggested as potential biomarkers in several diseases. However, in asbestosis, blood microRNAs are less explored. Since miR-32-5p, miR-143-3p, miR-145-5p, miR-146b-5p, miR-204-5p and miR-451a are involved in fibrotic processes and in cancer, expression of these microRNAs was analyzed in leukocytes and serum of asbestosis patients.

Methods
MicroRNA expression was analyzed in leukocytes and serum of 36 patients (26 affected by pleural plaques and 10 by asbestosis) and 15 healthy controls by real-time RT-PCR. Additionally, data analyses were performed regarding disease severity based on ILO classification.

Results
MicroRNA miR-146b-5p was significantly down-regulated in leukocytes of patients suffering from pleural plaques with a large effect indicated by η2p = 0.150 and Cohen’s f = 0.42, a value of difference of 0.725 and a 95% confidence interval of 0.070–1.381. In patients suffering from asbestosis miR-146b-5p was not significantly regulated. However, data analyses considering disease severity only, revealed that miR-146b-5p was significantly down-regulated in leukocytes of mildly diseased patients compared to controls with a large effect indicated by η2p = 0.178 and Cohen’s f = 0.465, a value of difference of 0.848 and a 95% confidence interval of 0.097–1.599. Receiver operating characteristic (ROC) curve and an area under the ROC curve value of 0.757 for miR-146b-5p indicated acceptable discrimination ability between patients suffering from pleural plaques and healthy controls. Less microRNAs were detectable in serum than in leukocytes, showing no significant expression differences in all participants of this study. Moreover, miR-145-5p was regulated significantly differently in leukocytes and serum. An R2 value of 0.004 for miR-145-5p indicated no correlation in microRNA expression between leukocytes and serum.

Conclusion
Leukocytes seem more suitable than serum for microRNA analyses regarding disease and potentially cancer risk assessment of patients suffering from asbestos-related pleural plaques or asbestosis. Long-term studies may reveal whether down-regulation of miR-146b-5p in leukocytes might be an early indicator for an increased cancer risk.
Antibiotic therapy by intrathecal or intraventricular approach for postsurgical meningitis or ventriculitis: a systematic review and meta-analysis
Authors: Florez-Perdomo William A. , Escobar-Cardona Daniela , Janjua Tariq , Agrawal Amit , Vasquez Harold , Lozada-Martinez Iván David , Moscote-Salazar Luis Rafael 
Published: May 2023

Abstract
Objective
To systematically review the evidence for intrathecal or intraventricular plus intravenous administration of antibiotics compared with standard management for postsurgical meningitis or ventriculitis.

Methods
The following databases were searched: MEDLINE, the Central Register of Controlled Trials (CENTRAL); PubMed, EMBASE; and reference list of articles.

Results
Administration of intrathecal/intraventricular antibiotics was associated with decreased mortality (OR 0.27 [95% CI 0.15–0.49] p =  < 0.00001), increased cure rate (OR 3.4 [95% CI 1.6–7.22] p = 0.001). There was no difference in the occurrence of reinfection rate, and in poor functional outcome (OR 0.57 [95% CI 0.21–1.60] p = 1.6 p = 0.29; OR 0.43 [95% CI 0.11–1.68] p = 0.22).

Conclusions
Intrathecal/intraventricular plus intravenous administration of antibiotics improves survival and cure rate in patients with postoperative meningitis or ventriculitis. More high-quality studies are needed.
The role of physiotherapy in recovery from generalized tetanus: two case reports
Authors: Fafolahan Abiola O. , Sodipo Oladunni P. , Adeoye Kafayat K. , Musa Badiru O. , Jegede Erioluwa , Musari Titilope , Adeyemi Blessing O. 
Published: May 2023

AbstractBackgroundA toxin produced by Clostridium tetani causes an acute illness called tetanus. Although there are still isolated incidences of the disease in emerging nations with social and economic squalor, the number of cases has dropped as a result of vaccination. This case report intends to describe the physical therapy treatments given to two patients at the Federal Medical Center in Abeokuta who were diagnosed with generalized tetanus.Case presentationsA 14-year-old girl and a 7-year-old boy were admitted to the Federal Medical Centre Abeokuta (FMCA) with symptoms of tetanus including an inability to open their mouths and muscle stiffness, and they were treated by pediatric physiotherapists with a combination of soft tissue massage, passive stretching, and passive movements to improve their muscle function. The patient in case 1 showed improvement in all clinical outcomes, such as muscle spasm, hypertonicity, muscle strength in the upper and lower limbs, and overall functional status, after undergoing therapy for 14 days. Similarly, the patient in case 2 also showed improvement in the same clinical outcomes after undergoing therapy for 8 days. Specifically, both patients showed Oxford muscle grading of 4/5 on both left and right limbs, and case 1 showed a functional independence measure score of 66/126 while case 2 showed a score of 56/126.ConclusionsThese case reports provide evidence that physical therapy interventions are effective in improving clinical outcomes and functional status in patients with generalized tetanus, and highlight the importance of incorporating physiotherapy in the management of this condition.
Evaluation of anti-atherosclerotic potential of Tinospora cordifolia in high-fat diet-induced atherosclerosis with associated changes in histological and biochemical parameters on Wistar rats
Authors: Nipate S. S. , Koradkar K. , Gojare S. A. 
Published: May 2023

Abstract
Background
Atherosclerosis is a chronic inflammatory disease. Atherosclerosis starts with fatty streak which is an accumulation of lipid-laden foam cells in the intimal layer of the artery. Atherosclerosis is a major cause of vascular disease globally. Hydro-alcoholic extract of Tinospora cordifolia stem possesses hypolipidemic and thrombolytic activity that might be effective in Atherosclerosis. Hence the present study is to determine the anti-atherosclerotic effect of ethyl acetate fraction of stem of Tinospora cordifolia (EATC) in the high-fat diet-induced atherosclerotic model on Wistar rats. Atherosclerosis was induced in male Wistar rats by high-fat diet (cholesterol, cholic acid, Propylthiouracil and salad oil) for 60 days. After completion of induction oral administration of EATC (100, 200 mg/kg) and Atorvastatin (10 mg/ kg) were given to animals for next 20 days. The success of the model was determined by histological and biochemical parameters at 80 days.

Results
EATC was able to significant decreased the raised serum level of total cholesterol, triglyceride, Low Density Lipoprotein, V Low Density Lipoprotein and significant increased the serum High Density Lipoprotein level as compared to the diseased control group. EATC exhibited less damage to the endothelial lining of the aorta and showed significant protective effect by lowering the deposition of cholesterol thereby increasing the lumen size compared to the diseased control group.

Conclusion
The present study reveals that Tinospora cordifolia could be a potential source of drug in treatment of Atherosclerosis.
Hydrogel as an alternative to agar for laboratory rearing of the green peach aphid Myzus persicae
Authors: Silva Ana Paula Nascimento , Chagas Camila Faria , de Andrade Alves Emanuel Lucas , de Castro Carvalho Vinícius , Haddi Khalid 
Published: May 2023

Abstract
Background
Rearing methodologies are critical for successful insect production. In this context, standard laboratory rearing of aphid species, like the green peach aphid Myzus persicae, uses plant leaf disks floating on an agar layer. However, agar is costly and its use in insect rearing is not always cost-effective. Here, the synthetic polymer hydrogel was tested as an affordable alternative for laboratory rearing of the green peach aphid.

Methods
Initially, the effects of three concentrations of hydrogel (0.3, 0.6, and 0.9 g per 100 ml) and agar (1 g per 100 ml) on the ability of aphids to complete their life cycle were compared. Then, using age-stage, two-sex life tables, the suitability of the hydrogel (0.6 g) as a substrate for two different host plants (e.i; Brassica oleraceae and Nicandra physalodes) under two different temperatures in aphids’ production was assessed. Subsequently, the response of the produced aphids in toxicological bioassays was tested.

Results
The hydrogel concentration of 0.6 g allowed the production of aphids in high numbers, similarly to the agar (1 g), without affecting their life cycle parameters or their reproductive outputs. Furthermore, the most significant differences between the evaluated treatments resulted mostly from the combined effects of the host plants and the temperatures. Therefore, colonies of M. persicae can be maintained over time producing sufficient offspring using N. physalodes leaves on a layer of hydrogel (0.6 g) at 20 °C. Moreover, in toxicological bioassays, the use of higher hydrogel concentrations (0.9 g) is recommended.

Conclusions
The hydrogel can be adopted as a viable alternative to replacing the widely used agar-based methodology for the green peach aphid rearing.
The impact of increased flooding caused by climate change on heritage in England and North Wales, and possible preventative measures: what could/should be done?
Authors: Anderson Kelly 
Published: May 2023

AbstractDespite 30 years of discussion, adaptation work is not routinely being carried out at heritage sites to minimise future impacts of climate change, particularly increased flooding risks. To understand barriers to essential work being carried out, interviews were carried out with six heritage sites that have already experienced river flooding to understand levels of preparation both before and after the flooding occurred. The results prove that despite funding, or lack of, being an important contributor, it is not the sole barrier to adaptation. Previously flooded sites still do not have a flood plan in place, outside agencies are preventing work being carried out, measures which have been put in place through listing status are prohibiting necessary work and delays in decision making about what is acceptable are all delaying adaptation while allowing more damage to be caused from weather impacts. While responsibility for adaptation lies locally this situation will not improve; responsibility needs to lie more centrally. While the principle of replacing like for like is a sound one with the best of intentions behind it, this is also contributing to losses in heritage and must be reconsidered when big decisions are finally made about what will be acceptable if impacts to heritage from future climate change are to be minimised.
Impact of legislative precision in the management of the Casbah
Authors: Hadji Farah , Aslan Zaki , Bougherira Quenza , Mushtaha Emad 
Published: May 2023

AbstractThe historic centre of Algiers (Casbah) presents a state of severe decay. Laws and legislative measures have been promulgated in the past three decades to provide an adequate framework for the conservation of the old city.This paper investigates the law and subsequent legal instruments used in heritage management and the impact of legislative provisions on the management of the living historic centre of the Casbah of Algiers.Before the issuance of Algerian Law n°98–04 relating to the protection of cultural heritage, the role of the various entities managing the Casbah was rather unclear. This law provides more details about the structure of urban heritage management. Additionally, a new heritage protection tool came into existence (the PPSMVSS, i.e., the Permanent Plan for Safeguarding and Enhancement of the Safeguarded Sector).Difficulties encountered in the field concerning the application of legislative tools caused considerable delays in preservation actions on the ground. This paper provides an analysis of the contradictions between text enforcement and conservation plans to understand the main reasons that led to the degradation of the historic area. Accordingly, the paper proposes a number of solutions to be implemented by the Algerian authorities.
Bayesian inversion for rapid multiwell interpretation of well logs and core data: Applications to unconventional organic-shale formations
Authors: Deng Tianqi , Ambía Joaquín , Torres-Verdín Carlos 
Published: May 2023

Multimineral analysis is widely used to calculate in situ porosity, fluid saturation, and mineralogy of rocks penetrated by a well. It delivers weight/volumetric concentrations of rock solid/fluid constituents by combining multiple borehole geophysical measurements and often is referred to as petrophysical joint inversion. Recently, a probabilistic method was developed for improved petrophysical estimation of rock constituents and their uncertainty from well logs. This method mitigates borehole and instrument-related environmental effects present in the measurements and efficiently propagates the uncertainty from measurement noise and rock-physics models (RPMs) to compositional/petrophysical estimations. The probabilistic estimation method is extended to the challenging conditions of multiple neighboring wells penetrating similar rock formations where borehole/drilling environmental conditions, borehole instruments, and measurement noise may vary from well to well. A calibration step is performed in a few key wells with core data and/or advanced borehole measurements; it enables the same RPMs and prior models to be implemented in nearby wells but with limited measurements. In addition, a precomputed surrogate model constructed with radial basis function interpolation is implemented for accurate and efficient nuclear-property calculations. The multiwell interpretation method is verified using synthetic and field examples of organic-rich shale formations. Results find that the probabilistic method (1) improves rock petrophysical/compositional estimations by mitigating borehole environmental effects and incorporating a priori knowledge, (2) yields regionally consistent compositions among wells, and (3) quantifies the uncertainty of the estimations. As a result, the probabilistic approach is especially suitable for assessing petrophysical/compositional properties in multiwell settings with complex rock constituents and/or limited borehole measurements.
New Insights in the Pathophysiology, Epidemiology, and Response to Treatment of Osteoporotic Vertebral Fractures
Authors: Skjødt Michael Kriegbaum , Abrahamsen Bo 
Published: May 2023

AbstractContextVertebral fractures (VFs) make up an important but challenging group of fractures often caused by osteoporosis. Osteoporotic fractures pose unique diagnostic challenges in generally requiring imaging for diagnosis. The objective of this narrative mini-review is to provide an overview of these recent advances in our knowledge of VF pathophysiology and epidemiology with particular focus on endocrine diseases, prevention, and treatment.Evidence AcquisitionWe searched PubMed on May 23, 2022, for studies of VFs in humans. Results were limited to papers available as full-text publications in English, published from 2020 and onward. This yielded 3457 citations. This was supplemented by earlier publications selected to add context to the recent findings.Evidence SynthesisStudies addressed VF risk in hyperthyreosis, hyperparathyroidism, acromegaly, Cushing syndrome, primary aldosteronism, and diabetes. For pharmaceutical treatment, new studies or analyses were identified for romosozumab and for weekly teriparatide. Several studies, including studies in the immediate pipeline, were intervention studies with vertebroplasty or kyphoplasty, including combination with stem cells or pharmaceuticals.ConclusionsEndocrinologists should be aware of the high likelihood of osteoporotic VFs in patients with endocrine diseases. Though licensed treatments are able to substantially reduce the occurrence of VFs in patients with osteoporosis, the vast majority of recent or ongoing randomized controlled trials in the VF area focus on advanced invasive therapy of the fracture itself.