bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Mechanisms of Pseudomonas-Assisted Plant Nitrogen Uptake: Opportunities for Modern Agriculture
Authors: Sanow Stefan , Kuang Weiqi , Schaaf Gabriel , Huesgen Pitter , Schurr Ulrich , Roessner Ute , Watt Michelle , Arsova Borjana 
Published: March 2023

Pseudomonas spp. make up 1.6% of the bacteria in the soil and are found throughout the world. More than 140 species of this genus have been identified, some beneficial to the plant. Several species in the family Pseudomonadaceae, including Azotobacter vinelandii AvOP, Pseudomonas stutzeri A1501, Pseudomonas stutzeri DSM4166, Pseudomonas szotifigens 6HT33bT, and Pseudomonas sp. strain K1 can fix nitrogen from the air. The genes required for these reactions are organized in a nitrogen fixation island, obtained via horizontal gene transfer from Klebsiella pneumoniae, Pseudomonas stutzeri, and Azotobacter vinelandii. Today, this island is conserved in Pseudomonas spp. from different geographical locations, which, in turn, have evolved to deal with different geo-climatic conditions. Here, we summarize the molecular mechanisms behind Pseudomonas-driven plant growth promotion, with particular focus on improving plant performance at limiting nitrogen (N) and improving plant N content. We describe Pseudomonas-plant interaction strategies in the soil, noting that the mechanisms of denitrification, ammonification, and secondary metabolite signaling are only marginally explored. Plant growth promotion is dependent on the abiotic conditions and differs at sufficient and deficient N. The molecular controls behind different plant responses are not fully elucidated. We suggest that superposition of transcriptome, proteome, and metabolome data and their integration with plant phenotype development through time will help fill these gaps. The aim of this review is to summarize the knowledge behind Pseudomonas-driven nitrogen fixation and to point to possible agricultural solutions. [Formula: see text] Copyright © 2023 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
High-Flow Nasal Cannula Compared With Noninvasive Positive Pressure Ventilation in Acute Hypoxic Respiratory Failure: A Systematic Review and Meta-Analysis
Authors: Chaudhuri Dipayan , Trivedi Vatsal , Lewis Kimberley , Rochwerg Bram 
Published: March 2023

OBJECTIVES:
To evaluate the efficacy and cost-effectiveness of high-flow nasal cannula (HFNC) when compared with noninvasive positive pressure ventilation (NIPPV) in patients with acute hypoxic respiratory failure (AHRF).

DATA SOURCES:
We performed a comprehensive search of MEDLINE, Embase, CINAHL, the Cochrane library, and the international Health Technology Assessment database from inception to September 14, 2022.

STUDY SELECTION:
We included randomized control studies that compared HFNC to NIPPV in adult patients with AHRF. For clinical outcomes, we included only parallel group and crossover randomized control trials (RCTs). For economic outcomes, we included any study design that evaluated cost-effectiveness, cost-utility, or cost benefit analyses.

DATA EXTRACTION:
Clinical outcomes of interest included intubation, mortality, ICU and hospital length of stay (LOS), and patient-reported dyspnea. Economic outcomes of interest included costs, cost-effectiveness, and cost-utility.

DATA SYNTHESIS:
We included nine RCTs (n = 1,539 patients) and one cost-effectiveness study. Compared with NIPPV, HFNC may have no effect on the need for intubation (relative risk [RR], 0.93; 95% CI, 0.69–1.27; low certainty) and an uncertain effect on mortality (RR, 0.84; 95% CI, 0.59–1.21; very low certainty). In subgroup analysis, NIPPV delivered through the helmet interface—as opposed to the facemask interface—may reduce intubation compared with HFNC (p = 0.006; moderate credibility of subgroup effect). There was no difference in ICU or hospital LOS (both low certainty) and an uncertain effect on patient-reported dyspnea (very low certainty). We could make no conclusions regarding the cost-effectiveness of HFNC compared with NIPPV.

CONCLUSIONS:
HFNC and NIPPV may be similarly effective at reducing the need for intubation with an uncertain effect on mortality in hospitalized patients with hypoxemic respiratory failure. More research evaluating different interfaces in varying clinical contexts is needed to improve generalizability and precision of findings.
Long-Term Prognosis Following Early Rehabilitation in the ICU: A Retrospective Cohort Study
Authors: Murooka Yukie , Sasabuchi Yusuke , Takazawa Tomonori , Matsui Hiroki , Yasunaga Hideo , Saito Shigeru 
Published: March 2023

OBJECTIVES:
Critically ill patients often have residual functional disabilities. Studies have shown that early rehabilitation improves short-term physical function. However, it remains unknown whether early rehabilitation affects long-term prognosis and healthcare resource utilization.

DESIGN:
Retrospective cohort study.

SETTING:
This study used an administrative claims database in Kumamoto Prefecture, Japan, from April 2012 to February 2017.

PATIENTS:
We identified patients who were admitted to the ICU and received rehabilitation. Eligible patients were divided into those who underwent rehabilitation within 3 days (early rehabilitation group) and after 4 or more days of ICU admission (delayed rehabilitation group). Propensity score matching analyses were conducted to compare the number of outpatient consultations within 1 year and 3 years after discharge from the index hospitalization, total duration of hospitalization after discharge, healthcare costs, and survival.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
A total of 6,679 patients were included in the study. Propensity score matching created 2,245 pairs. No difference was observed in the number of outpatient consultations 1 year after discharge, although there were differences between the groups 3 years after discharge. Long-term observation revealed a shorter overall duration of hospitalization (1.9 vs 2.6 mo; p < 0.001) and lower total costs ($28,159 vs $38,272; p < 0.001), as well as lower average costs per month ($1,690 vs $1,959; p = 0.001) in the early compared with the delayed rehabilitation group. No differences in survival were observed (log-rank test; p = 0.18).

CONCLUSIONS:
Starting rehabilitation within 3 days of ICU admission was associated with shorter durations of future hospitalization and lower healthcare costs. Early rehabilitation for ICU patients might be associated with reduced healthcare resource utilization.
Addressing the Mental Health Needs of Inmates Through Education for Correctional Officers—A Narrative Review
Authors: Darani Shaheen A. , McMaster Robert , Wolff Elena , Bonato Sarah , Simpson Alexander (Sandy) , Glancy Graham , Sandhu Kiren , Quinn Jason 
Published: March 2023

Introduction:
People with mental illness are overrepresented in correctional facilities. Correctional officers (COs) lack education to respond to inmates with mental illness. A review was conducted of mental health education programs for COs to identify factors related to effectiveness.

Methods:
Medical and criminal justice databases were searched for articles describing mental health education for COs. Studies including measurable outcomes were analyzed using an inductive analytic approach. The review adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for scoping reviews. Data were synthesized using Moore seven levels of outcomes for continuing professional development education. Findings were grouped by curriculum content and described according to levels of outcome.

Results:
Of 1492 articles, 11 were included in the analysis. Six described mental health programs, two described skill-specific programs, and three described suicide prevention programs. Programs reviewed content about mental illness, practical skills, included didactic and experiential teaching. The programs achieved level 5 on Moore taxonomy. Programs led to improvements in knowledge, skills, and attitudes among officers; however, improvements declined post-training. Officers were receptive to facilitators with correctional or lived mental health experience. Experiential teaching was preferred. Common themes related to programs' effectiveness included applicability to COs, information retention, program facilitators, and teaching methods.

Discussion:
There is limited, but positive literature suggesting that education programs are beneficial. The decline in improvements suggests need to ensure sustainability of improvements. This review can guide the planning of future education programs for COs based on continuing professional development best practices.
Factors Influencing General Dermatologists When Referring Patients With Head and Neck Melanoma for Mohs Micrographic Surgery: A Nationwide Cross-Sectional Survey
Authors: Neill Brett C. , Siscos Spyros M. , Bar Anna A. , Seger Edward W. , Latour Emile , Tolkachjov Stanislav N. 
Published: March 2023

BACKGROUND
Mohs micrographic surgery (MMS) for cutaneous melanoma has demonstrated higher cure rates, lower local recurrence rates, and improved survival compared with wide local excision (WLE). However, factors affecting referrals by general dermatologists for MMS of head and neck melanoma (HNM) are unknown.

OBJECTIVE
To elucidate referral factors and treatment perspectives of general dermatologists regarding MMS for melanoma in situ (MIS)/lentigo maligna (LM) and early-stage melanoma on the head and neck.

MATERIALS AND METHODS
A cross-sectional analysis was performed using survey responses of general dermatologists with membership in the American Academy of Dermatology.

RESULTS
A total of 231 and 132 of the 402 responding general dermatologists routinely referred melanoma in situ MIS/LM and early invasive melanoma for MMS, respectively. Lack of local access to a Mohs surgeon was the most common deterring reason for MIS/LM referral to MMS, whereas the preference for WLE was the most common deterring reason for early invasive melanoma.

CONCLUSION
Lack of local access to a Mohs surgeon treating HNM with MMS is the primary barrier in referrals to Mohs surgeons for MIS and LM. Among general dermatologists, WLE is preferred for early invasive HNM.
Current Fat Grafting Practices and Preferences: A Survey from Members of ISPRES
Authors: Vizcay Macarena , Saha Shivangi , Mohammad Arbab , Pu Lee L.Q. , Yoshimura Kotaro , Magalon Guy , Khouri Roger , Coleman Sydney , Rigotti Gino , DeFazio Stefania 
Published: March 2023

Background:
Fat grafting has established its niche in a wide spectrum of aesthetic and reconstructive procedures. A consensus-based method of harvest, processing, enrichment, injection, and assessment is lacking, despite the rising trends in its application. We conducted a survey among plastic surgeons to evaluate and identify trends of fat grafting practices.

Methods:
We conducted an electronic survey with a 30-item questionnaire of 62 members of the International Society of Plastic Regenerative Surgeons. We collected demographic information, techniques, and experiences related to large volume (100–200 ml) and small-volume (<100 ml) fat grafting.

Results:
The majority of the respondents worked predominantly as aesthetic surgeons. The donor area selection was based on the patient’s fat availability (59.7%). For fat enrichment, platelet-rich-plasma and adipose stem cells were routinely used by 12.9% and 9.7% of respondents, respectively. A 3- to 4-mm cannula with three holes was the most preferred instrument for large-volume fat harvesting (69.5%). For small-volume fat grafting, 2-mm cannulas (75.8%) with Mercedes tip (27.3%) were used most commonly. For processing, decantation of fat was performed by 56.5% of respondents (without exclusivity). For handheld injections (without exclusivity), respondents preferred a 1- to 2-mm cannula with a 1 cm3 syringe. The most popular method of outcome assessment was photographic evaluation.

Conclusions:
The respondents’ tendencies were similar to those reported in the previous literature, with some exceptions, such as the technique for preparing fat and enrichment. A wider cross-sectional survey, involving national delegates and global representatives of plastic surgeons, is anticipated.
Long-term progression pattern of myopic tractional maculopathy: outcomes and risk factors
Authors: Meng Jiaqi , Chen Yuxi , Cheng Kaiwen , Qi Jiao , Du Yu , Yao Yunqian , He Wenwen , Zhang Keke , Lu Yi , Zhu Xiangjia 
Published: March 2023

Abstract

Purpose:
To evaluate the long-term progression pattern of myopic tractional maculopathy (MTM) and the risk factors.

Methods:
The prevalence and grade of MTM were assessed with OCT at enrollment and at 2-year follow up. The severity of posterior staphyloma (PS) and presence of dome-shaped macula (DSM) was also evaluated.

Results:
Totally 610 highly myopic eyes of 610 patients were analyzed. The prevalence of epiretinal membrane (ERM), myopic retinoschisis (MS) and macular hole (MH) increased from 26.7%, 12.1% and 4.4% at enrollment to 41.1%, 18.2% and 9.5% at 2-year follow up, respectively. ERM progressed in 21.8% of eyes, but visual acuity (VA) did not decline significantly in these eyes. MS progressed in 6.8% of eyes, and MH progressed in 14.8% of eyes. Significantly greater BCVA reduction was detected in the eyes with MS or MH progression than the rest (p<0.05). Multivariate analysis showed longer axial length (AL), more-severe PS and absence of DSM were associated with MTM progression.

Conclusion:
In highly myopic eyes, long-term VA was relatively stable in those with ERM, but was significantly affected by MS or MH progression. Longer AL, more-severe PS and absence of DSM were risk factors for MTM progression.
Repeatability and Reproducibility of Corneoscleral Topography Measured With Scheimpflug Imaging in Keratoconus and Control Eyes
Authors: Yang Zhengfei , Wang Mengyi , Li Zhouyue , Hu Yin , Jiang Jinyun , Yu Fei , Zeng Junwen , Chen Weiyin , Yang Xiao 
Published: March 2023

Objectives:
To determine and compare the repeatability and reproducibility of anterior scleral parameters measured by the corneoscleral profile (CSP) module of Pentacam in keratoconus (KC) and control eyes.

Methods:
This is a prospective observational study. Thirty KC participants (30 eyes) and 24 control participants (24 eyes) were examined three times using the CSP. Sagittal height mean (SHM), sagittal height astigmatism (SHA), and mean bulbar slope (BSM) were measured in 12 mm and 16 mm chord lengths. The repeatability and reproducibility of these measurements were also assessed. Coefficients of variation (CoV), intraclass correlation coefficient (ICC), coefficient of repeatability (CoR1), and coefficient of reproducibility (CoR2) were adopted to assess the reliability.

Results:
In the KC and control groups, SHM showed high repeatability and reproducibility (coefficients of variation [CoVs]≤0.96%, intraclass correlation coefficient [ICCs]≥0.97), and SHM of control eyes showed higher repeatability and reproducibility than that of KC eyes at 12 mm chord length (KC group, CoRs ranged from 35.56 μm to 43.52 μm, control group, ranged from 23.50 μm to 30.31 μm) and 16 mm chord length (KC group, CoRs ranged from 79.54 μm to 81.58 μm, control group, ranged from 48.25 μm to 66.10 μm). Mean bulbar slope also showed high repeatability and reproducibility (CoVs≤3.65%, CoRs≤2.64). Furthermore, the SHA of control eyes showed higher repeatability and reproducibility when compared with KC eyes (control group: CoVs≤29.95%, KC group: CoVs≥32.67%).

Conclusions:
Keratoconus and control eyes demonstrated high repeatability and reproducibility when using CSP measurements, which may prove helpful in fitting contact lenses.
Comparison of Trabeculectomy Outcomes Performed by Residents in Training and Ophthalmologists
Authors: Lima-Fontes Mário , Faria-Pereira Ana , Leuzinger-Dias Mariana , Silva Marta Inês , Barbosa-Breda João , Araújo Joana , Estrela-Silva Sérgio , Benevides-Melo António , Alves Flávio , Tavares-Ferreira João 
Published: March 2023

Précis:Resident-performed trabeculectomies present higher intraocular pressure and lower complete success rate at 1 year.Purpose:To compare the 1-year outcomes of ab externo trabeculectomy between residents in training and staff ophthalmologists.Patients and Methods:This retrospective study included all consecutive eyes submitted to ab externo trabeculectomy between January 2015 to June 2020. A 1-year complete success rate was considered using all the following criteria: intraocular pressure (IOP)≤21 mm Hg and ≥6mm Hg without ocular hypotensive medications; IOP reduction≥30%; without loss of light perception, phthisis bulbi, and further glaucoma surgery (excluding suture lysis and bleb needling).Results:One hundred and ten eyes from 99 patients were included. Thirty percent (n=33) of the trabeculectomies were performed by residents. There were no significant preoperative differences between groups, apart from age at surgery, which was higher in the residents' group (72.39±6.83 vs. 62.00±15.07 years,P<0.001), and visual field index (Humphrey Field Analyzer), which was lower in the ophthalmologists’ group (51.81±34.74% vs. 32.04±33.83%,P=0.013). IOPat 1-, 3-, 6 months, and 1 year after surgery was significantly higher in the resident’s group (P<0.05). Resident-performed trabeculectomies achieved a significantly lower complete success rate when compared with the ophthalmologists’ group (39.39% vs. 64.94%,P=0.013). The overall rate of the postoperative complications and reintervention did not differ between groups, but the occurrence of a shallow anterior chamber was more frequent in the residents’ group (15.15% vs. 4.05%,P=0.037).Conclusions:Resident-performed trabeculectomies present significantly higher postoperative IOP levels and a lower complete success rate when compared with staff ophthalmologists. It is, therefore, fundamental to adopt strategies to change this gap, improve patient safety, and strengthen resident confidence.
Assessing the Diagnostic Accuracy of SD BIOLINE for Detection of Hepatitis C Virus: A Systematic Review and Meta-analysis
Authors: Weng Shu-Chang , Zhou Jie , Zhong Xiao-Ying , Xin Qing , Mai Yue-Xue , Ji Li-Qin , Li Ya-Ping , Cao Xun-Jie , Yang Wen-Hui , Chen Hao-Kai , Guo Xu-Guang 
Published: March 2023

Abstract
Hepatitis C virus (HCV) is a globally widespread ribonucleic acid virus that transmits through blood and sexual contact. Its morbidity and mortality are particularly higher in economically underdeveloped areas. Therefore, an economical and effective diagnostic method for detection of HCV is urgently needed. In this study, we evaluated the diagnostic accuracy of the SD BIOLINE rapid diagnostic test for HCV detection. We searched for studies related to SD BIOLINE and HCV in PubMed, Embase, Web of Science, and the Cochrane Library and then designed inclusion and exclusion criteria. After extracting valid data, the included literature was evaluated with the quality assessment tool Quality Assessment of Diagnostic Accuracy Studies. After our data analysis, the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic accuracy, summary receiver operating characteristic curve, funnel plot, box plot, and Fagan plot of the diagnostic method were determined. Nine articles with nine sets of data were finally included. The sensitivity and specificity were 0.94 and 0.98, respectively, the positive likelihood ratio was 79.53, the negative likelihood ratio was 0.05, the diagnostic odds ratio was 1590.32, and the summary receiver operating characteristic curve was 0.9958. The SD BIOLINE test has the advantages of high sensitivity, high specificity, low cost, and easy operation for diagnosing HCV. Therefore, we recommend using SD BIOLINE for rapid and effective screening of HCV, which is especially applicable for economically underdeveloped areas.
Rare case of horseshoe lung associated with scimitar syndrome in Palestine: a case report
Authors: Shrateh Oadi N. , Rajab Amjad , Issawi Mohammed , Owienah Haneen , Sulaiman Sa’d , Sweileh Thaer , Taqa Mohammad A. , Hijjeh Nizar , Asbeh Yousef A. 
Published: March 2023

Introduction:
The caudal and basal parts of the lungs are fused together in a rare congenital bronchopulmonary anomaly known as horseshoe lung. The majority of horseshoe lung cases are associated with scimitar syndrome. Most patients present with nonspecific symptoms. Multidetector pneumoangiography can be used to diagnose horseshoe lung, which shows that the isthmus of the pulmonary parenchyma traverses the midline, connecting the two lungs together. Treatment and prognosis are usually determined depending on the presence of other concomitant anomalies and the degree of symptom severity.

Case Presentation:
A 3-month-old-male patient presented with respiratory symptoms and a history of chest infection. Chest imaging revealed anomalous venous drainage from the right lower lobe of the lung, right lung hypoplasia with mediastinal shift, and a parenchymal isthmus extending between the two lungs. The patient was diagnosed with horseshoe lungs associated with scimitar syndrome. He was also found to have extralobar sequestration to the right lower lobe of the lung. The patient underwent surgical management in the form of tunneling of the anomalous vein into the left atrium using pericardium autograft ligation of the sequestration artery.

Clinical Discussion:
Because of its common association with other congenital malformations such as scimitar syndrome and cardiovascular defects, clinicians should be meticulous in the investigation and workup process of patients with horseshoe lung in order not to miss any of these associated abnormalities.

Conclusion:
Although it is very rare, horseshoe lung should be considered in the differential diagnosis of respiratory distress symptoms, especially in children younger than 1 year.
Acute hemorrhagic edema of infancy: a rare case report from Syria
Authors: Ataya Jamal , Hanifa Hamdah , Alsoud Eman 
Published: March 2023

Introduction and Importance:
Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis clinically characterized by the classic triad (palpable purpuric skin lesions, edema, and fever) and is commonly misdiagnosed as Henoch–Schönlein purpura. AHEI frequently occurs after infections, drug treatment, or vaccination, even though its etiology is undetermined. Besides having a sudden onset, AHEI is also characterized by a self-limiting course with complete and spontaneous recovery within 1–3 weeks.

Case Presentation:
We report a rare case of a 1-year-old Syrian infant who presented to the clinic with an abnormal rash covering his entire body following a viral respiratory infection. On physical examination, he had many purpuric lesions across his body, and laboratory tests revealed that they were within the normal range. AHEI was determined based on clinical evaluation and laboratory analysis.

Discussion and Conclusion:
The authors focus on this entity as a differential diagnosis of his Henoch–Schönlein purpura. To prevent potentially serious complications, doctors should recognize purpura lesions in children exposed to respiratory infections, which received particular drugs or were given vaccinations. Furthermore, there is no danger associated with this disease, and it is benign.