bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Promo Gratis Ongkos Kirim, Iklan, Dan Celebrity Endorsement Terhadap Keputusan Pembelian
Authors: Dia Maulud , Zakariya Novie Andriani 
Published: January 2025

This study aims to determine the effect of free shipping promos, advertisements, and celebrity endorsements on purchasing decisions. The influence to be proven is the effect of each independent variable on the dependent variable. This type of research is survey research, namely research that obtains data from a place naturally (not artificially) by distributing questionnaires, interviews, and so on. In this study, a sample of 53 respondents was obtained through an online questionnaire. Sampling uses a non-probability sampling technique which refers to judgment sampling which indicates sampling by selecting the subject in the most preferred place or in the best position to convey the required information. The research technique uses SPSS version 17. The results of this study indicate that free shipping promotions have an effect but not significant, which means they have no effect on purchasing decisions, advertising has no significant effect on purchasing decisions, and celebrity endorsements have no effect. and not significant.

Abstrak
Penelitian ini memiliki tujuan untuk mengetahui pengaruh dari promo gratis ongkos kirim, iklan, dan celebrity endorsement terhadap keputusan pembelian. Pengaruh yang ingin dibuktikan ialah pengaruh setiap variabel independenterhadap variabel dependen. Jenis penelitian ini adalah penelitian survei, yaitu penelitian yang mendapatkan data dari suatu tempat secara alamiah (bukan buatan) bisa dengan cara mengedarkan kuesioner, wawancara, dan sebagainya. Pada penelitian ini me mpergunakan sampel sebanyak 53 responden yang didapatkan melalui penyebaran kuesioner secara online. Pengambilan sampel menggunakan teknik non-probability sampling yang mengacu pada judgement sampling yang menandakan pengambilam sampel dengan memilih subjek di tempat yang paling disukai atau di posisi yang paling baik untuk menyampaikan informasi yang diperlukan. Teknik penelitian mengunakan SPSS versi 17. Hasil dari penelitian menunjukkan bahwa promosi gratis ongkos kirim berpengaruh tapi tidak signifikan yang berarti tidak berpengaruh terhadap keputusan pembelian, iklan tidak berpengaruh secara signifikan terhadap keputusan pembelian, dan celebrity emdorsement tidak berpengaruh dan tidak signifikan.
Increasing Participation and Completion Rates in Questionnaire Surveys of Primary Care Patients: Cluster-Randomized Study
Authors: Sebo Paul , Tudrej Benoit , Bernard Augustin , Delaunay Bruno , Dupuy Alexandra , Malavergne Claire , Maisonneuve Hubert 
Published: January 2025

Background
Participation and completion rates in questionnaire-based surveys are often low.

Objective
This study aims to assess participation and completion rates for a survey using paper and mixed mode questionnaires with patients recruited by research assistants in primary care waiting rooms.

Methods
This cluster-randomized study, conducted in 2023 in France, involved 974 patients from 39 practices randomized into 4 groups: “paper with incentive” (n=251), “paper without incentive” (n=368), “mixed mode with tablet” (n=187), and “mixed mode with QR code” (n=168). Analyses compared the combined paper group with the 2 mixed mode groups and the “paper with incentive” and “paper without incentive” groups. Logistic regressions were used to analyze participation and completion rates.

Results
Of the 974 patients recruited, 822 (women: 536/821, 65.3%; median age 52, IQR 37-68 years) agreed to participate (participation rate=84.4%), with no significant differences between groups. Overall, 806 patients (98.1%) answered all 48 questions. Completion rates were highest in the combined paper group (99.8%) compared to mixed mode groups (96.8% for paper or tablet, 93.3% for paper or QR code; P<.001). There was no significant difference in completion rates between the “paper with incentive” and “paper without incentive” groups (100% vs 99.7%).

Conclusions
Recruiting patients in waiting rooms with research assistants resulted in high participation and completion rates across all groups. Mixed mode options did not enhance participation or completion rates but may offer logistical advantages. Future research should explore incentives and mixed-mode strategies in diverse settings.
A Review on Computer Aided Drug Design – In Silico
Authors: Pranali R. Bhujade  , Khemutai G. Shedame  , Pooja R. Hatwar  , Dr. Ravindra L. Bakal  , Krushnali N. Nehar  , Ankita Y.Gawai  
Published: January 2025

The process of drug discovery takes a long time and costs a lot of money. Computer-Aided Drug Design (CADD) has become an important part of modern drug discovery because it speeds up the process and lowers prices. CADD includes many methods, such as Structure-Based Drug Design (SBDD) and Ligand-Based Drug Design (LBDD). These use computer programs to do things like molecular docking, virtual screening, QSAR, pharmacophore modeling, and molecular dynamics. LBDD is used when the shapes of receptors are unknown, while SBDD uses machine learning. This review provides a comprehensive overview of CADD methods, classification, principles, and uses in drug creation. The article discusses about how important it is to find targets, find lead compounds, and make things work better. It also talks about the role of computers in pharmaceutical chemistry and molecular biology. CADD has increased the speed and accuracy of drug finding, making it possible to find new medicines. The review shows how CADD could change the way drugs are made, help people who don't have access to proper medical care, and make patient results better. Researchers can speed up the process of finding new drugs by using CADD strategies. This review is a great resource for researchers, clinicians, and industry workers who want to use CADD in pharmaceutical research. Using CADD has changed the way drugs are found, and its continued growth could lead to better health for everyone.
Effects of Aqueous Extract of Cymbopogon Citratus Leaves on Exercise-Induced Oxidative Stress and Lipid Profile in Wistar Albino Rats
Authors: Ngarsou Pierre  , Agbodjogbé Kpèdétin Wilfrid Dieu-Donné  , Bonoy Lamou  , Taiwe Sotoing Germain  , Messan Folly  , Dansou Pierre  
Published: January 2025

Physical activity induces oxidative stress which causes fatigue which can be acute or chronic in athletes, responsible for a reduction in physical performance. The objective of the study was to evaluate the antioxidant activity of the aqueous extract of Cymbopogon citratus and its effects on the lipid profile in albino rats of the Wistar strain subjected to forced swimming. Twenty (25) male rats were fed a standard laboratory ration and divided into 5 batches of 5 rats, then subjected to a 14-day treatment with distilled water, 100 mg/kg, 200 mg/kg or 400 mg/kg of extract and swam every 2 days. On the 14th day, the rats except the control groups were subjected to the forced swimming test with a load of 10% of body weight attached to the tail. The results showed that Cymbopogon citratus reduces the DPPH radical and prevents tissue lipid peroxidation, dose dependent by decreasing Malondialdehyde level (p ˂ 0.001) in liver, lung and gastrocnemius muscle, increases dose dependent cellular concentrations of reduced Glutathione in liver (p ˂ 0.05) and studentthe specific activity of Superoxide dismutase in the lungs (p < 0.001). C. citratus reduced serum levels of total cholesterol (p ˂ 0.05) and LDL-cholesterol (p ˂ 0.01). C.citratus fights against oxidative stress induced by physical activity in rats. It would be interesting to test its action on other rat strains and endurance models.
Family foci of HDV infection in the Republic of Sakha (Yakutia)
Authors: Zamorshchikova O. M. , Sleptsova S. S. , Sleptsov S. S. 
Published: January 2025

This study is devoted to the analysis of the epidemiological situation of chronic hepatitis D in Yakutia, as a region where chronic viral hepatitis is widespread.Aim: To characterize family foci of chronic hepatitis D in the Republic of Sakha (Yakutia).Materials and methods: The study is based on data from the registry “Chronic viral hepatitis in the Republic of Sakha (Yakutia)” and official statistics of the Territorial Administration of Rospotrebnadzor in the Republic of Sakha (Yakutia) for 2013­2023. There was conducted an analysis of case histories of patients with chronic hepatitis D, including those from family foci of HDV infection (n = 13). Statistical data processing was carried out using the IBM SPSS Statistics 26.0 program.Results: The article presents data on the number of registered cases of chronic forms of viral hepatitis B and D in Yakutia, analyzed family foci of HDV infection, highlights of the features of infection and the dynamics of disease development in family groups associated with infection of spouses and perinatal transmission.Conclusion: The work reflects the importance of natural routes of transmission of HDV infection and emphasizes the relevance of perinatal prevention of hepatitis B, including the use of vaccination and specific HBV immunoglobulin for family members with replicative form of hepatitis B and D. This study has practical significance for the development of programs for the prevention and early detection of HDV infection.
Experience in using specific recombinant monoclonal antibodies in comorbid patients with coronavirus infection
Authors: Sokotun S. A. , Simakova A. I. , Mikhailov A. O. , Plekhova N. G. 
Published: January 2025

Introduction: against the background of the ongoing incidence of coronavirus infection, the selection of therapy often requires individual approaches, especially in comorbid patients. Despite the emergence of specific prevention methods and new antiviral drugs, there are risk groups for severe disease and high mortality.Target. To evaluate the effectiveness and safety of the use of SARS­CoV­2 neutralizing antibodies for the treatment of comorbid patients with coronavirus infection.Materials and methods: A retrospective study was conducted to evaluate the clinical efficacy of virus­neutralizing antibodies for the treatment of comorbid patients with coronavirus infection who were hospitalized in 2022. A total of 244 patient records (mean age 60.0±14.2 years) with confirmed SARS­CoV­2 coronavirus infection were analyzed. The first group consisted of patients who received monoclonal virusneutralizing antibodies (monotherapy with Sotrovimab or Regdanvimab, combination therapy with Casirivimab and Imdevimab, or Bamlanivimab and Etesevimab), and the second group consisted of patients without therapy. All patients were comorbid. The most frequently observed nosologies were: hypertension (74.1%), chronic kidney disease (55.2%), malignant neoplasms (31%), 1–3 degree of obesity (22.4%), diabetes mellitus (17.2%), and autoimmune diseases (17.2%). In the comparison groups, the duration of the disease, the area of lung tissue damage, the duration of respiratory support, the percentage of complications, the need to use immunosuppressive therapy, as well as the percentage of fatal outcomes, were assessed.Results: The duration of the disease in patients who received monoclonal virus­neutralizing antibodies was 16.0±8.1 days, the area of lung tissue damage was on average 14.9±13.0%, the duration of respiratory support was 2.2±3.1 days, complications of coronavirus infection were noted in 31%, the mortality rate decreased to 1.7%. In patients without therapy with these drugs, complications of the disease were detected 2 times more often – in 64% of cases, the duration of the disease was 20.0±6.1 days, the area of lung tissue damage was on average 21.7±12.1%, and the duration of respiratory support was 8.0±6.1 days. Immunosuppressive therapy was used significantly more often in patients without therapy with antiviral monoclonal antibodies (51.2%) than with it (3.4%). A study of the clinical efficacy of various monoclonal antibodies showed an advantage in using Regdanvimab in comorbid patients, as indicated by the absence of fatal outcomes and a reduction in the duration of the disease to 9.8±4.8 days.Conclusions: Preparations of synthetic recombinant monoclonal neutralizing antibodies to SARS­CoV­2, provided that they are used in the early stages of the disease, significantly reduce the severity of coronavirus infection, the development of complications and significantly reduce mortality in comorbid patients.
Identification of rare single nucleotide polymorphisms in the genome of hospitalized COVID-19 patients
Authors: Perederiy A. A. , Komissarov A. B. , Danilenko D. M. , Venev E. V. , Konopleva S. A. , Korzhanova M. , Pisareva M. M. , Gusev D. A. , Lioznov D. A. 
Published: January 2025

The aim of this controlled study was to identify polymorphisms in the genome of COVID­19 patients associated with the frequency of hospitalization.Materials and methods: Two groups of patients were formed: the main group – 56 patients with COVID­19, hospitalized at least twice during the study period, and the control group – 107 patients for whom only one hospitalization with COVID­19 was confirmed during the study period. Wholeexome sequencing of residual nasopharyngeal swabs from patients hospitalized with COVID­19 was performed on the MGI platform, followed by bioinformatics analysis and gene enrichment analysis.Result: For the first time, exome sequencing was performed from oropharyngeal swabs from 163 patients hospitalized with COVID­19 using the MGI platform. In the main group, unique variants of genetic polymorphisms were identified, including six previously undescribed ones.Conclusion: No genetic variants were statistically significantly associated with single or multiple hospitalizations of COVID­19 patients in the study. Nasopharyngeal swabs can be used for whole exome sequencing. Further studies are needed to identify unique genetic variants responsible for susceptibility to infectious diseases. Nasopharyngeal swabs can be used for whole­exome sequencing. Further studies are needed to identify unique genetic variants responsible for susceptibility to infectious diseases.
Analysis of Protein Metabolism by Biochemical Parameters in Holstein Cows for Preventing the Reproductive System Pathologies
Authors: Novak M. D. , Novak A. I. 
Published: January 2025

Introduction. Protein metabolism disorder (dysproteinemia) in dry and freshly calved cows often becomes a complicating factor during mastitis and endometritis and leads to the animal's liveweight decrease. Timely detection of physiological disorders and diseases in the highly productive animals by means of a biochemical blood test is the basic method to preserve the optimal indicators of herd productivity and prevent the economic losses, however, this issue is insufficiently followed up in the dairy farms. The aim of the present research is to analyse the protein metabolism in highly productive Holstein cows by biochemical parameters for timely prevention of the dysproteinemia and pathologies of the reproductive system.Materials and Methods. The research was carried out in the conditions of a large dairy farm in the Central district of the Russian Federation in the period from March to June 2019. The objects of the research were 45 highly productive Holstein cows (dry, freshly calved and milking cows — 15 heads in each group). To analyse the protein metabolism and inflammatory processes in the tissues and organs of dry and freshly calved cows, the following biochemical blood parameters were studied: total protein, albumin, globulin, urea, creatinine, uric acid, transferase enzymes — ASAT and ALAT. The analysis was carried out by comparing the results obtained with the normal values of physiological parameters.Results. In 5 out of 15 dry cows, the albumin level was 5.3–16% lower, and in freshly calved cows it corresponded to the lower limit of the physiological norm values. The total protein in the blood of the freshly calved cows was lower than normal by 20–23%, on average. The concentration of urea in blood of all cows under research was reduced by 1.5– 2.5 times, creatinine was 2–2.5 times elevated (56–89%). The ASAT enzyme activity in 75% of dry and in all freshly calved cows was 2–4 times higher. The reserve alkalinity parameter was 0,6–2,4 times less than the physiological norm values in all animals under research.Discussion and Conclusion. During the research it was found that the compliance of the protein level in the diet of productive animals with the biological needs of their organisms should be determined by the concentration of total protein and albumin in the blood serum, and dysproteinemia and various pathologies of the reproductive system — by the content of urea, creatinine and activity of the aspartate aminotransferase (ASAT) enzyme.
CULTURAL VALUES IN PARUNTUK KANA LITERATURE: A STUDY IN DATARA VILLAGE, TOMPOBULU, GOWA REGENCY
Authors: Syamhari  , Ishak Ihdiana , Hidayat Amirullah 
Published: January 2025

This study examines the Paruntuk Kana among the people of Datara Village, Tompobulu, Gowa Regency. This research aims to analyze the use of Paruntuk Kana among the community in Datara Village, Tompobulu, Gowa Regency, while examining the cultural values embedded within its practice in the same context. This field research employs a descriptive qualitative methodology. Data collection was conducted through interviews. The findings of this study reveal that Paruntuk Kana is a local literary work that remains prevalent in the Datara village community. Paruntuk Kana embodies the refinement of language, which is integral to the community's way of life and facilitates communication and the expression of humanitarian aspects within society. The indicators of linguistic subtlety and gentleness in Paruntuk Kana literature, as evidenced by the research, demonstrate that the diction in Paruntuk Kana plays a crucial role in addressing the audience, imbued with the values of politeness and local traditions. The cultural values embedded in Paruntuk Kana literature are local values that reflect linguistic refinement, mutual respect, honor, and the practice of life based on humanist principles.
External economic and financial control - Comparative constitutional perspective
Authors: Gera Anton 
Published: January 2025

Abstract
There can be no talk of external economic and financial control in a dictatorial state. Consequently, external control is a significant component of democratic states. As for the definition of external audit, it consists of an assessment carried out by an independent and competent entity. This assessment allows the compilation of an opinion in relation to national or international standards on the financial status, internal control of the institution, procedures and any activity of a given institution. Audit is an independent assessment that aims to obtain evidence in relation to a specific object and its objective assessment to determine to what extent predetermined criteria have been met or not. The concept of audit can be applied both in the public and private sectors, where it was invented. Regarding auditing in the public sector, there should be a distinction between internal and external audit. Internal Audit is an independent activity that provides objective assurance and advice to management designed to add value and improve the operations of a public entity. As for the origins of auditing in general through the use of inventory, it is found in Domesday, created by William I of England. In the late Middle Ages, there are references to auditors and auditing in Italy, France and England as an activity and as a formalization of the institution of control. In this sense main objective of this manuscript is a comparative constitutional perspective of the economic and financial control.
The role of school leadership in media literacy in Albanian primary education
Authors: Isaraj Merita , Gjolleshi Irma 
Published: January 2025

Abstract
This paper focuses on the influence of media in the educational system and the need for the curricula improvements, Albanian primary education case. Living in the digital era, people are definitely faced with many challenges, mainly regarding the vast information which is often excessive and comes from a variety of sources. The information students are provided with, is not always true or the appropriate knowledge they have to acquire.
In this sense, the target group that is mostly exposed to this issue are the primary and even secondary school children who do not have the maturity to analyze, filter and select what the internet offers them. Students graduating from K-12 education need media literacy skills to engage, participate, and learn in a world in which literacy must keep pace with rapidly changing technologies.
In this context, school leaders can play a very important educational and sensitizing role and become supporters of media literacy projects. Moreover, the transformative influence of principals in fostering teacher professional development emerges as a critical catalyst for literacy improvement. Leadership influence is essential in finding the instruments to improve the curricula and involve all the influential factors in raising the awareness and to prepare the future citizens with all the media sources they are living with.
Through surveys, we have collected quantitative and qualitative data from primary school leaders in South Albania regarding their attitude towards media literacy, their knowledge on the subject, as well as their ability and willingness to include media literacy in curricular or extracurricular activities with the goal of educating students from an early age to be capable of successfully facing the challenges of the digital era that are advancing and gaining more and more ground.
Antimicrobial resistance pattern and species distribution profile of aerobic bacteria causing sterile body fluid infection from a tertiary care hospital
Authors: Khatiyan Shubham , Singh Peetam , Pandey Anita 
Published: January 2025

Objectives:
Body fluids such as pleural fluid, ascitic fluid, and cerebrospinal fluid are sterile but they can get infected by different microorganisms leading to life-threatening infections. We conducted this study to evaluate the distribution profile of various aerobic bacteria and their antimicrobial resistance pattern isolated from sterile body fluids from the patients attending a tertiary care hospital in North India.

Materials and Methods:
This hospital-based cross-sectional observational study was conducted in the Department of Microbiology of a tertiary care hospital. A total of 495 sterile body fluid samples were processed for species-level identification of aerobic bacteria by conventional methods following standard laboratory procedures. The antimicrobial susceptibility testing was performed by Kirby–Bauer disc diffusion method according to clinical and laboratory standards institute guidelines 2020.

Results:
Out of a total of 495 sterile body fluid samples, 48 were found positive on culture for bacterial pathogens. The predominant organisms isolated from sterile body fluids were Acinetobacter species (35%), followed by Klebsiella species (23%), Escherichia coli (13%), Pseudomonas species (12%), Staphylococcus aureus (13%), and Streptococcus species (4%). All of the Gram-negative isolates were 100% sensitive to Colistin followed by amikacin (67.50%) and gentamicin (60%). The Gram-positive isolates were 100% sensitive to vancomycin and linezolid followed by gentamicin (50%).

Conclusion:
Infections of sterile body fluids can lead to high morbidity and mortality. The knowledge of the bacteriological and antimicrobial resistance profile of bacteria causing sterile body fluid infections is vital in determining appropriate antimicrobial therapy.