bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiotherapy of orbital metastases: a systematic review of management and treatment outcomes on behalf of palliative care study group of Italian association of radiotherapy and clinical oncology (AIRO)
Authors: Pezzulla Donato , Di Franco Rossella , Zamagni Alice , Pastore Francesco , Longo Silvia , Dominici Luca , Lillo Sara , Ciabattoni Antonella , Arcidiacono Fabio , Deodato Francesco , Muto Paolo , Morganti Alessio Giuseppe , Cellini Francesco , Maranzano Ernesto 
Published: September 2023

Objectives: We search the current literature on data regarding the role of RT in OM treatment, focusing on the improvement of symptoms and patient quality of life. Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Results: From 340 citations, 60 papers were finally selected: 45 case reports and 15 case series. The case reports accounted for 47 patients. In 37/39 cases (95%), EBRT was done. Patients were mainly treated with 3DCRT, IMRT, and with SBRT. The most used RT regimens were 30 Gy in 10 fractions (23%) and 20–25 Gy in 5 fx (13%). No sever toxicity was reported. A median LC of 11 months (range 1–54 months) and a median OS of 12 months (range 1–54 months) were registered. Among the case series, a total of 457 patients were examined, 227 of whom underwent RT. The main used techniques were 3DCRT, CK, GK, SBRT, and BRT. RT doses could vary from 30 Gy/10 fractions to 60 Gy/30 fractions, 50 Gy/5 fractions, or 16.5–21 Gy in single fraction. No toxicity above G2 was reported. ORR could vary between 75 and 100%. Only two study provided information on response duration: a mean LC time of 22.8 months and a mean time to local progression of 5 months (range: 3–7). Regarding OS, the data were heterogeneous, ranging between 1 and 54 months. Conclusions: RT for OM seems to be a safe and feasible option. More information on the RT ideal techniques and dose are still needed. Advances in knowledge: This paper tried to sum up the few and fragmented data on the use of radiotherapy for orbital metastases: the possible option ranged from 3D- and 2D-CRT to SBRT, CK, and GK, with different possible fractionations (30Gy in 10 fractions, 60 Gy/30 fractions, 20-50 Gy/5 fractions, or 16.5-21 Gy in single fraction). Regardless of the chosen approach, almost all treated patients experienced a benefit after RT in terms of OM-related symptom intensity reduction and a good acute and late toxicity profile.
Arm-only combined transarterial and transvenous access for neurointerventional procedures: a double-center retrospective study
Authors: Zhu Deyuan , Wang Chuanchuan , Ma Peipei , Qi Dayong , Cao Wei , Li Suya , Du Meng , He Juanling , Ye Shifei , Song Tonghui , Hu Rongguo , Li Peng , Zheng Tianheng , Liu Jianmin , Fang Yibin 
Published: September 2023

Objective
This study aims to share our experience with the arm-only combined transarterial and transvenous access approach for neurointerventional procedures and evaluate its efficacy and safety.

Methods
The arm-only combined transarterial and transvenous access approach was performed using the right/bilateral proximal radial arteries and the right forearm superficial vein system, guided by ultrasonic guidance. Arterial access closure was achieved using a transradial band radial compression device, while manual compression was utilized for venous approach closure.

Results
Thirteen procedures were successfully performed using the arm-only combined transarterial and transvenous access approach, yielding favorable outcomes. The procedures included dural arteriovenous fistula embolization (seven cases), cerebral arteriovenous malformation embolization (four cases), venous sinus thrombosis catheter-directed thrombolysis and intravenous thrombectomy (one case), and cerebral venous sinus stenosis manometry (one case). All procedures were uneventful, allowing patients to ambulate on the same day. At discharge, all patients exhibited modified Rankin scores of 0–2, without any access site or perioperative complications.

Conclusion
This double-center study preliminarily demonstrates the feasibility and safety of arm-only combined transarterial and transvenous access applied in neurointerventional procedures for complicated cerebrovascular diseases. The proximal radial artery and forearm superficial vein are recommended as the primary access sites. Unobstructed compression is strongly recommended for radial approach closure.

Advances in knowledge
This study aimed to add evidence and experience on the arm-only combined transarterial and transvenous access, as a new approach, for neurointerventional treatment that required arteriovenous approaches.
How to 19F MRI: applications, technique, and getting started
Authors: Maxouri Olga , Bodalal Zuhir , Daal Mariah , Rostami Sajjad , Rodriguez Ivonne , Akkari Leila , Srinivas Mangala , Bernards René , Beets-Tan Regina 
Published: September 2023

Abstract
Magnetic resonance imaging (MRI) plays a significant role in the routine imaging workflow, providing both anatomical and functional information. 19F MRI is an evolving imaging modality where instead of 1H, 19F nuclei are excited. As the signal from endogenous 19F in the body is negligible, exogenous 19F signals obtained by 19F radiofrequency coils are exceptionally specific. Highly fluorinated agents targeting particular biological processes (i.e., the presence of immune cells) have been visualised using 19F MRI, highlighting its potential for non-invasive and longitudinal molecular imaging. This article aims to provide both a broad overview of the various applications of 19F MRI, with cancer imaging as a focus, as well as a practical guide to 19F imaging. We will discuss the essential elements of a 19F system and address common pitfalls during acquisition. Last but not least, we will highlight future perspectives that will enhance the role of this modality. While not an exhaustive exploration of all 19F literature, we endeavour to encapsulate the broad themes of the field and introduce the world of 19F molecular imaging to newcomers. 19F MRI bridges several domains, imaging, physics, chemistry, and biology, necessitating multidisciplinary teams to be able to harness this technology effectively. As further technical developments allow for greater sensitivity, we envision that 19F MRI can help unlock insight into biological processes non-invasively and longitudinally.
A note on positive solutions of Lichnerowicz equations involving the $\Delta_\lambda$-Laplacian
Authors: Duong Anh Tuan , Nguyen Thi Quynh 
Published: September 2023

In this paper, we are concerned with the parabolic Lichnerowicz equation involving the $\Delta_\lambda$-Laplacian
$$
v_t-\Delta_\lambda v=v^{-p-2}-v^p,\quad v> 0, \quad
\mbox{ in }\mathbb R^N\times\mathbb R,
$$
where $p> 0$ and $\Delta_\lambda$ is a sub-elliptic operator of the form
$$
\Delta_\lambda=\sum_{i=1}^N\partial_{x_i}\big(\lambda_i^2\partial_{x_i}\big).
$$
Under some general assumptions of $\lambda_i$ introduced by A.E. Kogoj
and E. Lanconelli in Nonlinear Anal. {\bf 75} (2012), no.\ 12, 4637-4649,
we shall prove a uniform lower bound of positive
solutions of the equation provided that $p> 0$. Moreover, in the case $p> 1$,
we shall show that the equation has only the trivial solution $v=1$.
As a consequence, when $v$ is independent of the time variable, we obtain the similar results for	the elliptic Lichnerowicz equation involving
the $\Delta_\lambda$-Laplacian
$$
-\Delta_\lambda u=u^{-p-2}-u^p,\quad u> 0,\quad \mbox{in }\mathbb R^N.
$$
Temporal Bin Packing with Half-Capacity Jobs
Authors: Muir Christopher , Marshall Luke , Toriello Alejandro 
Published: September 2023

Motivated by applications in cloud computing, we study a temporal bin packing problem with jobs that occupy half of a bin’s capacity. An instance is given by a set of jobs, each with a start and end time during which it must be processed (i.e., assigned to a bin). A bin can accommodate two jobs simultaneously, and the objective is an assignment that minimizes the time-averaged number of open or active bins over the horizon; this problem is known to be NP hard. We demonstrate that a well-known “static” lower bound may have a significant gap even in relatively simple instances, which motivates us to introduce a novel combinatorial lower bound and an integer programming formulation, both based on an interpretation of the model as a series of connected matching problems. We theoretically compare the static bound, the new matching-based bounds, and various linear programming bounds. We perform a computational study using both synthetic and application-based instances and show that our bounds offer significant improvement over existing methods, particularly for sparse instances. Funding: This work was supported by the National Science Foundation [Grants CMMI-1552479 and NSF GRFP]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoo.2023.0002 .
Hospital-Wide Inpatient Flow Optimization
Authors: Bertsimas Dimitris , Pauphilet Jean 
Published: September 2023

An ideal that supports quality and delivery of care is to have hospital operations that are coordinated and optimized across all services in real time. As a step toward this goal, we propose a multistage adaptive robust optimization approach combined with machine learning techniques. Informed by data and predictions, our framework unifies the bed assignment process across the entire hospital and accounts for present and future inpatient flows, discharges, and bed requests from the emergency department, scheduled surgeries and admissions, and outside transfers. We evaluate our approach through simulations calibrated on historical data from a large academic medical center. For the 600-bed institution, our optimization model was solved in seconds and reduced off-service placement by 24% on average and boarding delays in the emergency department and postanesthesia units by 35% and 18%, respectively. We also illustrate the benefit of using adaptive linear decision rules instead of static assignment decisions. This paper was accepted by Carri Chan, healthcare management. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4933 .
Tinidazole versus Ornidazole in Amebic Dysentery in Children (a double blind trial)
Authors: Panggabean Amer , Sutjipto Adi , Aldy Dachrul , Sutanto A. H. , Siregar Helena 
Published: September 2023

Between January and June 1978, a double blind trial was conducted in 3.5 children, suffering from Amebic Dysentery in the OPD of the General Hospital Medan.
The children were treated ambulatory, either with Tinidazole or Ornidazole, with a dose of 50 mg/kg body weight/day for 3 consecutive days, under close supervision. All the children, except on in the Tinidazole group (case no. 20), gave excellent responses.
Disappearance of ameba's blood and mucus from the stools occurred in all of the patients after 2 days of treatment. There was no significant difference in the results of treatment with Tinidazole and Ornidazole (p>0.05). Side effects were minimal. Marked vomiting occurred in one patirnt of the Ornidazole group.
Access structures determined by uniform polymatroids
Authors: Kawa Renata , Kula Mieczysław 
Published: September 2023

Abstract
In this article, all multipartite access structures obtained from uniform integer polymatroids were investigated using the method developed by Farràs, Martí-Farré, and Padró. They are matroid ports, i.e., they satisfy the necessary condition to be ideal. Moreover, each uniform integer polymatroid defines some ideal access structures. Some objects in this family can be useful for the applications of secret sharing. The method presented in this article is universal and can be continued with other classes of polymatroids in further similar studies. Here, we are especially interested in hierarchy of participants determined by the access structure, and we distinguish two main classes: they are compartmented and hierarchical access structures. The main results obtained for access structures determined by uniform integer polymatroids and a monotone increasing family

Δ

\Delta

can be summarized as follows. If the increment sequence of the polymatroid is non-constant, then the access structure is connected. If

Δ

\Delta

does not contain any singletons or the height of the polymatroid is maximal and its increment sequence is not constant starting from the second element, then the access structure is compartmented. If

Δ

\Delta

is generated by a singleton or the increment sequence of the polymatroid is constant starting from the second element, then the obtained access structures are hierarchical. They are proven to be ideal, and their hierarchical orders are completely determined. Moreover, if the increment sequence of the polymatroid is constant and

∣
Δ
∣
>
1

| \Delta | \gt 1

, then the hierarchical order is not antisymmetric, i.e., some different blocks are equivalent. The hierarchical order of access structures obtained from uniform integer polymatroids is always flat, that is, every hierarchy chain has at most two elements.
Assessment of pubertal onset and disorders of puberty in Indian children and youth with type-1 diabetes
Authors: Oza Chirantap , Antani Misha , More Chidvilas , Mondkar Shruti , Khadilkar Vaman , Gondhalekar Ketan , Khadilkar Anuradha 
Published: September 2023

Abstract

Objectives
Disorders of pubertal development are enlisted as associated conditions in children and adolescents with type-1 diabetes (T1D). We conducted this study with objective (1) To estimate the median age at onset of puberty and luteinizing hormone (LH) and sex-steroid concentrations in Indian adolescents with T1D and (2) To assess the impact of puberty on glycemic control and insulin resistance (IR).

Methods
This cross-sectional study included 399 children and youth aged 6–23 years with T1D. Demographic, anthropometric, biochemical and pelvic ultrasound data were collected using standard protocols. IR was calculated using estimated glucose disposal rate and puberty was assessed using Tanner staging.

Results
Median age at onset of thelarche, pubarche and menarche were 11.3, 11.4 and 12.8 years in girls and that of gonadarche and pubarche were 10.6 and 12.7 years for boys. The mean LH and sex-steroid concentrations of subjects with T1D were similar to healthy subjects at each stage of puberty. The cut-offs of LH and sex-steroids derived from healthy Indian children yielded high sensitivity and specificity in determining pubertal onset. The prevalence of precocity, delayed puberty, ovarian cysts and polycystic ovaries was 0.9 , 5.1, 5.1 and 8.6 %, respectively. Glycaemic control and insulin sensitivity was poor in pubertal subjects.

Conclusions
The age at onset of puberty, LH, and sex-steroid concentrations in subjects with T1D were like otherwise healthy Indian children with poor glycemic control and IR in pubertal subjects. Although most complications of T1D are associated with poor glycemic control, pubertal disorders were significantly low despite the less-than-optimal glycemic control.
Wavelength multiplexing infrared metasurfaces for protein recognition and trace detection
Authors: Dong Shiqing , Dong Chao , Shen Kesheng , Zheng Yun , Sun Jie , Zhen Cheng , Hu Haiyang , Zhang Feng , Zhang Zhe , Liu Hongchao , Lu Hai 
Published: September 2023

Abstract
Infrared metasurfaces have exhibited exceptional optical properties that differ from naturally occurring metallic and dielectric nanostructure, enabling non-destructive and label-free sensing in a broadband region. However, implementing wavelength multiplexing sensors in broadband infrared has faced significant challenges. These challenges arise from the difficulty in efficiently exciting high Q resonances at specific wavelengths and the inability to individually tune each resonance. Herein, we present a dual resonant metasurface that utilizes a metal–dielectric–metal plasmonic grating and a dielectric–metal channel. By adjusting the vertical and horizontal structures of metasurface, we can independently modify the spectrum of the metasurface in the near-infrared and mid-infrared regions. This broadband infrared metasurface exhibits robust spectral regulation, enabling a polarization-dependent strategy for the dual-resonance. It offers a competitive advantage over traditional metallic nanostructure in refractive index sensing at the second near-infrared window and ultrasensitive vibrational spectroscopy in mid-infrared. Specifically, our proposed metasurface achieves protein concentration sensing and dynamic monitoring of protein concentration in the infrared two-zone. Additionally, it enhances the mid-infrared absorption of amide II with a high Q resonance. The metasurface which combines wavelength multiplexing and polarization dependent switch for protein recognition and trace detection, presents a novel approach for developing high-performance sensors and Integrated photonics sensors in the broadband infrared region.
Using guaiacol as a capping agent in the hydrothermal depolymerisation of kraft lignin
Authors: Ahlbom Anders , Maschietti Marco , Nielsen Rudi , Hasani Merima , Theliander Hans 
Published: September 2023

Abstract
The depolymerisation of softwood kraft lignin was investigated, under hydrothermal conditions at 290 °C and 250 bar, with guaiacol in the reactor feed to evaluate its impact on the formation of char and on the molecular weights of the products. The effect of residence time was investigated in the time span 1–12 min. Lignin is depolymerised during the process and guaiacol is both formed and consumed during the reaction, with clearly noticeable changes as early as in the first minute of reaction. Although the addition of guaiacol in the reactor feed causes a reduction in the weight average molecular weight of the products, the yield of char increases. Longer residence times result in repolymerisation of the reaction products as well as a further increase in the yield of monoaromatic components and char.
A múzeumok változó szerepei a felnőtt tanulók készségeinek formálásában – Trendek és kérdések a készségek európai évében (European Year of Skills 2023)
Authors: Németh Balázs 
Published: September 2023

Ez a rövid írás azt mutatja be, hogy a felnőttek tanulásának aktuális trendje és kérdései rámutatnak a felnőttek tanulását ösztönző múzeumi szerepek változásaira, különös tekintettel a készségek fejlesztésére irányuló tanulási programok és szolgáltatások szerepére.
Noha a Készségek Európai Éve programjait főleg a foglalkoztatási célú készségfejlesztés szemlélete uralja, mégis a Szociális Jogok Európai Pillérének üzenetei alapján a felnőttek tanulását fejlesztő szakembereknek fel kell hívniuk a figyelmet arra, hogy a társadalmi integráció és beilleszkedés abban az esetben lehet sikeres az egyén számára, amennyiben a folyamatos, tehát életen át tartó tanulás révén erősödhetnek és megújulhatnak úgy az alapkészségek, mint az ún. soft skill-ek, melyek fejlesztésében a múzeumok lényeges szerepet játszanak. E folyamat sikere pedig attól függ, hogy a tanulási részvételt támogató hatékony módszerek milyen módon járulnak hozzá a transzformatív, a megtapasztalásra és együttműködésre építő tanuláshoz reflektív környezetben.
A múzeumi lifelong learning sokfélesége érzékelteti, hogy a felnőttek tanulásának hatékonysága és szükséglet-orientáltsága összefügg intergenerációs és interkulturális összefüggésekkel, melyek kiegészülnek a digitális és technológiai kihívások, a COVID-pandémia, valamint a globalizáció és a válságok okozta nehézségekkel. Mindezek alapján jelezzük, hogy a múzeumok négy irányban formálják szerepüket:

felelős a társadalmi és közösségi véleményformálóként folyamatokban részt vesz a befogadás, aktív és demokratikus állampolgárság és a méltányos magatartás megjelenítésében;
karakteres kulturális szereplőként és véleményformálóként hozzájárul a kreatív, a sokféleségre épülő, ugyanakkor az identitásra és a kritikus gondolkodásra egyaránt építő felfogások formálásához;
oktatási szereplőkként erősítik a hatékony tudás- és készség-megosztást a múzeumi lifelong learning sokféleségével akár személyes részvételre, akár virtuális együttműködésekre építve;
a fenntarthatóságot szem előtt tartó és azt képviselő tudatos véleményformálóként rámutatnak a környezeti érzékenyítés, a szolidaritás témájára orientáló és a felnőtteket cselekvéssel jobb helyzetbe hozó tanulások szerepére;

Ezen felelősséget is magában hordozó irányok erősíthetik azt a célt, hogy a múzeumok, melyek egyébként is összekapcsolják a felnőttek tanulásában a részvétel és a teljesítmény kérdéseit a kollaboratív és a párbeszédre, dialógusra építő tanuló-központú felfogással, eredményesen járulhassanak hozzá a felnőttek készségeinek, továbbá aktív állampolgárként felelősségeik gyakorlásának igényéhez. Ennek alapján a múzeumok értékes közösségi felnőtt-tanulási térként részt vehetnek a társadalom és a környezet tudatos, fenntartható formálásában.
Diversity of freshwater hydrozoans from Neotropical region: an annotated inventory of species
Authors: Deserti María I. , Stampar Sergio N. , Acuña Fabián H. 
Published: September 2023

Introduction: Worldwide, six genera of the class Hydrozoa are recognized in continental waters: the cosmopolitan Hydra, the colonial Cordylophora and Pachycordyle, the medusae Craspedacusta and Limnocnida and the little polyp Calpasoma. Even though interest in cnidarians has grown in recent years, those restricted to freshwater continue to be relegated and there is even little published information on the ubiquity of certain species. In the Neotropical region, knowledge about its distribution is still very scarce.
Methods: We reviewed the global literature on the subject and different online database platforms, presenting in this work a nomenclator, including discussions of the status of some species and provide the most recent identification key.
Results: This analysis reveals that in 15 countries corresponding to the Neotropical region, the finding of freshwater hydrozoans has been reported. Panama, Brazil and Argentina are the countries with the highest number of reports.
Conclusions: The heterogenity of environments where these genera have been found (from the Strait of Magellan to Mexico) offers a clear vision of their wide distribution and great adaptability to different environments. This study evidence the knowledge gap that still exists about the Neotropical freshwater hidrozoans and the importance of systematizing the current information about their distribution, biology and ecology, especially for those species considered invasive.
Fructus, Attianus, Ariomanus
Authors: Szabó Melinda 
Published: September 2023

AbstractThe study includes two inscriptions from Poetovio both on altars, one dedicated to Mithras, the other to Isis, both erected for the wellbeing of a person. In addition to the findspot they have in common that both persons mentioned in them were employees of the publicum portorium Illyrici customs office. This insight is the basis for the new additions to the study, as for both inscriptions it was possible to reinterpret the previously known inscriptions based on the pattern used by customs post employees, which could be observed on other inscriptions. The new addition will allow the two inscriptions to be included in the research on the operation and staffing of the Illyricum customs district.