bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Competency Framework for Participatory Modeling
Authors: Elsawah Sondoss , Bakhanova Elena , Hämäläinen Raimo P. , Voinov Alexey 
Published: February 2023

AbstractParticipatory modeling (PM) is a craft that is often learned by training ‘on the job’ and mastered through years of practice. There is little explicit knowledge available on identifying and documenting the skills needed to perform PM. In the modeling literature, existing attempts to identify relevant competencies have focused on the specific technical skills required for specific technical model development. The other skills required to organize and conduct the stakeholder process seem to be more vaguely and poorly defined in this context. The situation is complicated by PM being an essentially transdisciplinary craft, with no single discipline or skill set to borrow ideas and recommendations from. In this paper, we aim to set the foundation for both the practice and capacity-building efforts for PM by identifying the relevant core competencies. Our inquiry into this topic starts with reviewing and compiling literature on competencies in problem-solving research areas related to PM (e.g., systems thinking, facilitated model building, operations research, and so forth). We augment our inquiry with results from a PM practitioners’ survey to learn how they perceive the importance of different competencies and how the scope of these competencies may vary across the various roles that participatory modellers play. As a result, we identified five core competency areas essential for PM: systems thinking, modeling, group facilitation, project management and leadership, and, more recently, designing and running virtual workshops and events.
Terahertz Beam Steering: from Fundamentals to Applications
Authors: Monnai Yasuaki , Lu Xuyang , Sengupta Kaushik 
Published: February 2023

AbstractFree-space transmission of terahertz (THz) waves opens great opportunities for wireless applications including sensing and communication in the 6G era and beyond. Owing to their wider bandwidths and shorter wavelengths, the use of THz waves enhances information capacity and spatial resolution while downsizing aperture sizes compared to microwaves. On the other hand, the shorter wavelengths of THz waves can involve severe path loss. To compensate for the path loss, directional transmission based on beam steering is indispensable. In this article, we review the development of THz beam steering, which has been a longstanding challenge as well as the generation of high-power THz waves. While the use of active or passive phased arrays is the predominantly utilized approach to implement beam steering, other approaches based on variable diffractive structures and frequency dispersive structures offer low-cost alternatives. We also emphasize that application-driven system design approaches, in which THz beam steering is tightly coupled to signal processing, have been emerging to overcome hardware limitations.
Arabincoside B isolated from Caralluma arabica as a potential anti-pneumonitis in LPS mice model
Authors: El-Shiekh Riham A. , Nabil Ghazal , Shokry Aya A. , Ahmed Yasmine H. , Al-Hawshabi Othman S. S. , Abdel-Sattar Essam 
Published: February 2023

AbstractAcute lung injury (ALI) is a life-threatening condition usually associated with poor therapeutic outcomes and a high mortality rate. Since 2019, the situation has worsened due to the COVID-19 pandemic. ALI had approximately 40% of deaths before COVID-19, mainly due to the dysfunction of the blood–gas barrier that led to lung edema, failure of gas exchange, and dyspnea. Many strategies have been taken to mitigate the disease condition, such as diuretics, surfactants, antioxidants, glucocorticoids, heparin, and ventilators with concomitant sedatives. However, until now, there is no available effective therapy for ALI. Thus, we are presenting a new compound termed Arabincoside B (AR-B), recently isolated from Caralluma arabica, to be tested in such conditions. For that, the lipopolysaccharide (LPS) mice model was used to investigate the capability of the AR-B compound to control the ALI compared to standard dexamethasone. The results showed that AR-B had a significant effect on retrieving ALI. A further mechanistic study carried out in the serum, lung homogenate, histological, and immunohistochemistry sections revealed that the AR-B either in 50 mg/kg or 75 mg/kg dose inhibited pro-inflammatory cytokines such as IL-6, IL-13, NF-κB, TNFα, and NO and stimulated regulatory cytokines IL-10. Moreover, AR-B showed a considerable potential to protect the pulmonary tissue against oxidative stress by decreasing MDA and increasing catalase and Nrf2. Also, the AR-B exhibited an anti-apoptotic effect on the lung epithelium, confirmed by reducing COX and BAX expression and upregulating Bcl-2 expression. These results pave its clinical application for ALI.
Implementing artificial intelligence education for middle school technology education in Republic of Korea
Authors: Park Woongbin , Kwon Hyuksoo 
Published: February 2023

AbstractThe purpose of this study is multifold: First, to develop an educational program using artificial intelligence (AI) in middle school free semester system of South Korea. Second, to verify the program’s effectiveness, the study clarified the definition of AI and AI education and considered their meaning in technology education. This study used three steps: preparation, development, and improvement. In the preparation step, this study set the theme and purpose of the AI program and selected the free semester activity type “theme selection activity.” After analyzing the technology curriculum and extracting AI-related elements in the development step, this study laid out the program for 16 h of class time. In the improvement step, to augment the program’s validity, the researcher revised and supplemented it as a whole through expert consultation. This research differentiated the developed program from the AI education program of other subjects and specialized it, focusing on the specificity of technology education. The study emphasized the social impact of the latest technology, ethics of AI, physical computing using AI, and technological problem-solving activity using AI. The final developed program was applied to the students, and students participated in a pretest and posttest. The study used the PATT and AI competency test tools. The PATT results showed a significant increase in the mean of both constructs in “interest in technology” and “career aspirations in technology.” In AI competency, the mean of two constructs increased significantly in “social impact of AI” and “AI performance.” In particular, “AI performance” showed the largest increase. There was no statistically significant change in “interaction with AI.” The study results confirmed that the developed AI program was effective in technology education and career exploration, which is the primary purpose of the free semester. In addition, it was possible to confirm the technology educational value of the AI education program centered on technological problem-solving. These research results have implications for bringing AI into technology education.
The teleNIDA: Early Screening of Autism Spectrum Disorder Through a Novel Telehealth Approach
Authors: Riva Valentina , Villa Laura , Fulceri Francesca , Arduino Giuseppe Maurizio , Leonti Guido , Valeri Giovanni , Casula Laura , Zoccante Leonardo , Puttini Elena , Sogos Carla , Presicce Mariaelena , Bentenuto Arianna , Apicella Fabio , Molteni Massimo , Scattoni Maria Luisa 
Published: February 2023

AbstractThe COVID-19 pandemic has fast-tracked interest in telehealth methods to guarantee the continuity of care of children with Autism Spectrum Disorder (ASD). Store-and-forward telehealth approaches offer the opportunity to facilitate timely screening of ASD, allowing parents to record videos of their child’s behaviors, subsequently shared with clinicians that provide an assessment remotely. This study aimed to examine the psychometric properties of a new telehealth screening tool, the teleNIDA, administered in home settings for remote observation of early signs of ASD in toddlers aged 18–30 months. Results showed good psychometric properties of the teleNIDA, as compared to the gold standard in-person assessment, and the predictive validity on the diagnosis of ASD at 36 months was demonstrated. This study supports the teleNIDA as a promising level 2 screening tool for ASD able to speed up diagnostic and intervention processes.
Acute and long-term results with the 3rd generation visually guided laser balloon ablation system for pv isolation
Authors: Funasako Moritoshi , Petrů Jan , Hála Pavel , Janotka Marek , Škoda Jan , Chovanec Milan , Šedivá Lucie , Reddy Vivek Y. , Neužil Petr 
Published: February 2023

Abstract
Background
Visually guided laser balloon ablation is known as an effective pulmonary vein (PV) isolation device. The third-generation laser balloon ablation system (X3) equipped with compliant balloon and an automated motor-driven laser output mechanism, namely RAPID mode, has been clinically proven for PV isolation.

Methods
PV isolation with X3 was performed in all the patients with paroxysmal and early-stage persistent atrial fibrillation (AF). Acute data for PV isolation and clinical outcomes including supraventricular tachyarrhythmia (SVT: AF, atrial flutter, or atrial tachycardia)-free survival rate beyond 1 year were analyzed.

Results
A total of 110 patients (62 ± 13 years old, 80% of paroxysmal AF) were treated with X3. RAPID mode with was utilized to achieve PV isolation in all cases. In combination with RAPID mode and spot mode laser ablation, 91.1% (380/417) of veins were isolated on the first circumferential lesion set and did not require touch-up ablation and during the index procedure 100% of attempted veins were isolated. The mean procedure time was 77.0 ± 22.7 min and LA dwell time was 61.9 ± 22.0 min. Total duration of laser application was 5.1 ± 2.3 min per vein. At 1 year, SVT-free survival rate was 93.7% in paroxysmal AF patients, and 81.1% in persistent AF patients.

Conclusions
A novel continuous automatic laser balloon ablation system was proved to be safe and effective for both paroxysmal and persistent AF patients. The clinical result demonstrated that PV isolation with X3 could achieve a high SVT-free survival rate.
Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis
Authors: Arango-Franco Carlos A. , Migaud Mélanie , Ramírez-Sánchez Isabel Cristina , Arango-Bustamante Karen , Moncada-Vélez Marcela , Rojas Julián , Gervais Adrian , Patiño-Giraldo Santiago , Perez-Zapata Lizeth J. , Álvarez Álvarez Jesús A. , Orrego Julio César , Roncancio-Villamil Gustavo , Boisson-Dupuis Stéphanie , Jouanguy Emmanuelle , Abel Laurent , Casanova Jean-Laurent , Bustamante Jacinta , Arias Andrés A. , Franco José Luis , Puel Anne 
Published: February 2023

Abstract

Background
Cryptococcosis is a potentially life-threatening fungal disease caused by encapsulated yeasts of the genus Cryptococcus, mostly C. neoformans or C. gattii. Cryptococcal meningitis is the most frequent clinical manifestation in humans. Neutralizing autoantibodies (auto-Abs) against granulocyte–macrophage colony-stimulating factor (GM-CSF) have recently been discovered in otherwise healthy adult patients with cryptococcal meningitis, mostly caused by C. gattii. We hypothesized that three Colombian patients with cryptococcal meningitis caused by C. neoformans in two of them would carry high plasma levels of neutralizing auto-Abs against GM-CSF.

Methods
We reviewed medical and laboratory records, performed immunological evaluations, and tested for anti-cytokine auto-Abs three previously healthy HIV-negative adults with disseminated cryptococcosis.

Results
Peripheral blood leukocyte subset levels and serum immunoglobulin concentrations were within the normal ranges. We detected high levels of neutralizing auto-Abs against GM-CSF in the plasma of all three patients.

Conclusions
We report three Colombian patients with disseminated cryptococcosis associated with neutralizing auto-Abs against GM-CSF. Further studies should evaluate the genetic contribution to anti-GM-CSF autoantibody production and the role of the GM-CSF signaling pathway in the immune response to Cryptococcus spp.
Compression-based Facies Modelling
Authors: Manzocchi Tom , Walsh Deirdre A. , Carneiro Marcus , López-Cabrera Javier 
Published: February 2023

AbstractSimple object- or pixel-based facies models use facies proportions as the constraining input parameter to be honored in the output model. The resultant interconnectivity of the facies bodies is an unconstrained output property of the modelling, and if the objects being modelled are geometrically representative in three dimensions, commonly-available methods will produce well-connected facies when the model net:gross ratio exceeds about 30%. Geological processes have more degrees of freedom, and facies in high net:gross natural systems often have much lower connectivity than can be achieved by object-based or common implementations of pixel-based forward modelling. The compression method decouples facies proportion from facies connectivity in the modelling process and allows systems to be generated in which both are defined independently at input. The two-step method first generates a model with the correct connectivity but incorrect facies proportions using a conventional method, and then applies a geometrical transform to scale the model to the correct facies proportions while retaining the connectivity of the original model. The method, and underlying parameters, are described and illustrated using examples representative of low and high connectivity geological systems.
Role of long noncoding RNAs; BDNF-AS and 17A and their relation to GABAergic dysfunction in Egyptian epileptic patients
Authors: Zayed Aya A. , Seleem Mae M. , Darwish Hebatallah A. , Shaheen Amira A. 
Published: February 2023

AbstractEpilepsy is a chronic neurological disorder characterized by recurrent unprovoked seizures. Lately, long noncoding RNAs (lncRNAs) have been increasingly appreciated as regulators of epilepsy-related processes, however, their functional role in its pathogenesis is still to be explored. This study investigated the expression levels of lncRNAs; BDNF-AS and 17A in the sera of Egyptian patients with idiopathic generalized and symptomatic focal epilepsy and correlated their levels with brain-derived neurotrophic factor (BDNF), phosphorylated cAMP reaction element -binding protein (p-CREB), gamma- aminobutyric acid (GABA) and glutamate, to underline their related molecular mechanism. A total of 70 epileptic patients were divided into two clinical types, besides 30 healthy controls of matched age and sex. The expression levels of both lncRNAs were markedly upregulated in epileptic groups versus the healthy control group with predominance in the symptomatic focal one. Epileptic patients showed significantly lower levels of BDNF, p-CREB, GABA along with significant increase of glutamate levels and glutamate/ GABA ratio, especially in symptomatic focal versus idiopathic generalized epileptic ones. The obtained data raised the possibility that these lncRNAs might be involved in the pathogenesis of epilepsy via inhibition of GABA/p-CREB/BDNF pathway. The study shed light on the putative role of these lncRNAs in better diagnosis of epilepsy, particularly symptomatic focal epilepsy.
The Association Between Neurocognitive Disorders and Gustatory Dysfunction: A Systematic Review and Meta-Analysis
Authors: Mantovani Elisa , Zanini Alice , Cecchini Maria Paola , Tamburin Stefano 
Published: February 2023

AbstractOlfactory and gustatory dysfunction have been reported in mild and major neurocognitive disorders (NCDs), with variable results. While olfactory dysfunction has been consistently explored, reports on gustatory alterations are limited. We systematically reviewed case-control studies evaluating gustatory function in NCDs with various etiologies and different neuropathology. Eighteen studies were included in the systematic review, and eight were included in the meta-analysis. Most studies were on Alzheimer’s disease (AD) and Parkinson’s disease (PD). Pooled analyses showed worse global taste threshold and identification (sour in particular) scores in AD than controls and worse global, sweet, and sour scores in AD compared to mild cognitive impairment (MCI). PD with MCI showed worse global, sweet, salty, and sour scores than controls and cognitively unimpaired PD. Taste dysfunction was differentially associated with the severity of cognitive deficits. Gustatory dysfunction may represent a potential cross-disease chemosensory biomarker of NCD. Whether gustatory alterations may be a pre-clinical biomarker of NCD requires further studies.
Thinking in circles: Kojève and Russian Hegelianism
Authors: Jacobs Isabel 
Published: February 2023

AbstractThis paper analyzes Russian-French philosopher Alexandre Kojève’s dialogue with proponents of Hegelianism and phenomenology in Soviet Russia of the 1920–30s. Considering works by Dmytro Chyzhevsky, Ivan Ilyin, Gustav Shpet, and Alexandre Koyré, I retrace Hegelian themes in Kojève, focusing on the relation between method and time. I argue that original reflections on method played a key role in both Russian Hegelianism and Kojève’s work, from his famous Hegel lectures to the late fragments of a system. As I demonstrate, Kojève’s Hegelianism was significantly shaped by his encounter with Ilyin’s 1918 commentary on Hegel, a detailed study of the relation between method and the experience of time. However, in Kojève’s hands, Ilyin’s ideas were transformed, some radicalized, others abandoned. Comparatively reading texts by these thinkers in their respective contexts, I resituate and evaluate claims that Hegel’s method was less dialectical than phenomenological. I finally argue that early Soviet Hegelian discourses not only shaped the trajectory of Kojève’s Hegelianism but also radically anticipated concepts of time in French post-structuralism.
Introducing a four-fold way to conceptualize artificial agency
Authors: van Lier Maud 
Published: February 2023

AbstractRecent developments in AI-research suggest that an AI-driven science might not be that far off. The research of for Melnikov et al. (2018) and that of Evans et al. (2018) show that automated systems can already have a distinctive role in the design of experiments and in directing future research. Common practice in many of the papers devoted to the automation of basic research is to refer to these automated systems as ‘agents’. What is this attribution of agency based on and to what extent is this an important notion in the broader context of an AI-driven science? In an attempt to answer these questions, this paper proposes a new methodological framework, introduced as the Four-Fold Framework, that can be used to conceptualize artificial agency in basic research. It consists of four modeling strategies, three of which were already identified and used by Sarkia (2021) to conceptualize ‘intentional agency’. The novelty of the framework is the inclusion of a fourth strategy, introduced as conceptual modeling, that adds a semantic dimension to the overall conceptualization. The strategy connects to the other strategies by modeling both the actual use of ‘artificial agency’ in basic research as well as what is meant by it in each of the other three strategies. This enables researchers to bridge the gap between theory and practice by comparing the meaning of artificial agency in both an academic as well as in a practical context.
Community composting strategies for biowaste treatment: methodology, bulking agent and compost quality
Authors: Alves David , Villar Iria , Mato Salustiano 
Published: February 2023

AbstractThe European Union’s commitment to increase recycling and recovery rates of municipal solid waste requires significant changes in current waste management. Local governments are developing various strategies for treating the organic fraction of municipal waste (biowaste) via composting. Community composting centres (CCC), green waste collection, treatment points and community gardens are some of these new approaches. Population density and spatial distribution, together with the existence of community green areas, determine the location of the various infrastructures for recycling local biowaste. The composting process consumes high amounts of bulking agent (BA) necessary to provide the structure that allows, amongst other uses, biowaste aeration and microbial surface colonisation. Shredded green waste from parks, gardens and households can be used as BA in community composting and home composting. In this study, a total of 46 compost samples obtained from CCC with two types of handling were analysed: 22 samples treated by vertical flow (VF) and 24 samples treated by horizontal flow (HF). The HF model allowed better use of the volume of modular composting units and the VF model required less effort and time for the CCC operator. Mature, stable and high-nutrient-content composts were obtained with both models. These composts met the legal requirements to be used as an organic amendment, and they can be delivered to the participants or used in community gardens in the municipality.
Seasonal variation observed in microplastic deposition rates in boreal lake sediments
Authors: Saarni S. , Soininen T. , Uurasjärvi E. , Hartikainen S. , Meronen S. , Saarinen T. , Koistinen A. 
Published: February 2023

Abstract
Purpose
The sediment trap method allows measurements of vertical microplastic flux rate into sediments and provides comparable information of the spatial microplastic deposition rates. Such data are essential for comparison of the microplastic pollution rates in different sedimentary systems and for future risk assessments.

Materials and methods
We monitored microplastic fluxes using sediment traps in a boreal lake seasonally during 1 year. The sites represent different level of exposure to anthropogenic activities, from construction work to the open water site. Microplastic fluxes were compared to sediment characteristics (organic content) and sediment accumulation rates.

Results and discussion
The highest annual microplastic deposition rate (2300 items m−2 year−1) was recorded at snow disposal site, a location where the snow collected from the city streets during winter is transported. The lowest rate was observed at the control site (660 items m−2 year−1) upstream from the city. Our results reveal the seasonal variation in microplastic deposition rates. In general, the highest microplastic flux rates were measured during growing season, accompanied with higher sedimentation rate. The low microplastic deposition rate during winter is likely explained by ice cover, frozen soil, and snow cover in the catchment. In contrast, microplastic concentration was higher in winter samples due to ceased sediment transport from catchment to lake. The sediment accumulation rate did not predict microplastic accumulation rate.

Conclusion
Our data suggest seasonal variation in microplastic deposition rates. The microplastic flux rates compared to their concentrations indicates that sites with high sedimentation rates can lead to underestimation of microplastic deposition and hence hamper recognition of hot spots.

Graphical Abstract