bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Threshold Technique Study to Understand Patient Preference for Smooth Versus Textured Breast Implants
Authors: Wood Dallas , Williams Peyton N. , Thompson Jessica E. , Peinado Susana , Tilley Avery A. , Gebben David , Major Jacqueline M. , Weinberg Jessica P. , Yoon Sung W. , Tarver Michelle E. 
Published: January 2025

Background:
Breast implant surfaces are categorized as smooth or textured. Compared with smooth implants, textured surface implants have a higher risk of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but may have a lower risk of capsular contracture (CC). This study aimed to quantify whether survey respondents would be willing to accept a higher risk of BIA-ALCL in exchange for the potential reported benefits of textured breast implants.

Methods:
We fielded a threshold technique survey to 405 respondents from 4 cohorts: (1) patients with breast cancer who were considering but did not receive reconstruction with implants, (2) patients with breast cancer who had received reconstruction with implants, (3) persons considering breast augmentation with implants, and (4) patients who had received breast augmentation with implants.

Results:
The average maximum increase in the risk of BIA-ALCL that the survey respondents were willing to accept in exchange for textured implants—with both a teardrop-shaped option and a 10% reduction in the risk of CC—were as follows: 0.83% for patients who were considering breast reconstruction, 0.61% for patients who had received breast reconstruction, 0.85% for persons considering breast augmentation, and 0.60% for patients who had received breast augmentation.

Conclusions:
We found respondents generally were willing to accept the higher risk of BIA-ALCL associated with textured implants to gain the potential benefit of reduced risk of CC and the option of the teardrop-shaped implant. Patient perspectives and preferences are integral, and continued assessment of patient perspectives can help inform regulatory and care paradigms.
Utility of Free Fibula Flap With an Extended Banana-shaped Skin Paddle for Oro-mandibular Reconstructions
Authors: Hamahata Atsumori , Konoeda Hisato , Shirakura Satoshi , Yagihara Kazuhiro , Sakurai Hiroyuki 
Published: January 2025

Summary:
The free fibula flap is a common technique for mandibular bone defects. However, its limited skin paddle is disadvantageous in cases with significant soft-tissue defects. A free fibula dual-skin paddle flap is used for medium-sized soft-tissue defects. Just as the anterolateral thigh flap can be extended through linking vessels, so the peroneal skin flap can be extended to the adjacent proximal area through linking vessels. This has led to the development of the free fibula banana-shaped flap. From 2021 to 2023, 8 patients, with an average age of 68.1 years, underwent head and neck reconstructive surgery using the free fibula banana-shaped flap at the Saitama Cancer Center in Japan. Their primary disease, defect sites, flaps, bone size, and postoperative complications were analyzed retrospectively. The blood flow of the flap was examined using intraoperative indocyanine green imaging. All 8 patients had successful operations with only 1 partial necrosis of the flap tip. Four patients had buccal mucosa cancers, 3 had osteoradionecrosis of the jaw, and 1 had lower gingival cancer. The flap size averaged 25.0 ± 3.0 cm (long axis) and 4.1 ± 0.4 cm (short axis), with a transplanted bone length of 8.4 ± 1.9 cm. The number of perforators was 1–3 in the distal to the central area. All flaps’ microcirculation was confirmed with intraoperative indocyanine green imaging; the average time was 3 minutes 59 seconds. Postoperative complications included 1 surgical site infection and 1 minor salivary leak. The free fibula banana-shaped flap is a good option for head and neck reconstructive surgery in medium-sized soft-tissue defects with mandibular bone defects.
Evaluating the Safety and Satisfaction of HYAcorp MLF2 for Noninvasive Buttock Augmentation: A Multicenter Study
Authors: Crabai Piero , Campos-Martínez Luis , Marchetti Francesco , Fantozzi Fabio , Marques Ruben , Fontenete Silvia 
Published: January 2025

Background:
The increasing demand for noninvasive gluteal augmentation using hyaluronic acid (HA) gel highlights the need for research into its safety and effectiveness. This study aimed to assess the safety and satisfaction levels of patients and physicians regarding HA body filler for buttock enhancement. It also explores variations in outcomes across different injection sites and among different practitioners.

Methods:
This retrospective, observational, descriptive multicenter study analyzed the outcomes of using a body HA filler (HYAcorp MLF2) for buttock augmentation across 4 Italian centers, with a 6-month follow-up period. Patients’ and physicians’ satisfaction levels were measured immediately postprocedure, and adverse events were monitored throughout the study period.

Results:
Thirty-five subjects received injections, with an average volume of 85.1 ± 42.2 mL per subject injected. Throughout follow-up, 94% of patients and 100% of physicians rated the improvement as “very good” or “good.” Adverse events were generally mild-to-moderate, typically resolving within 2–7 days. The most frequently recorded adverse effects were swelling, pain, and redness. No significant differences were observed among injectors (P > 0.05).

Conclusions:
HYAcorp MLF2 is safe and effective for buttock augmentation, demonstrated by high satisfaction rates and manageable, mild-to-moderate adverse events, with no significant variation based on practitioner experience or clinic site.
Reconstruction of Back Defect from Giant Congenital Melanocytic Nevus Using Dermal Substitute Matrix
Authors: Makkawi Kareem W. , Beaineh Paul T. , Emsieh Saif E. , Chrabieh Edwin E. , Ibrahim Amir E. 
Published: January 2025

Summary:
Giant congenital melanocytic nevi are large pigmented premalignant lesions present at birth that have an associated risk of malignant transformation. Full-thickness excision of these lesions would be required to eliminate this risk. However, giant nevi can leave behind large defects that can be challenging to reconstruct. We present the case of a pediatric patient with a lesion occupying the entirety of the back, or around 18% total body surface area, and in whom Integra and meshed skin grafts were successfully used. This represents the largest defect size in the literature resulting from a giant nevus that has been treated by this method. Full take of the skin grafts was observed 26 days from the excision of the lesion with satisfactory functional outcomes.
Herpetic Endotheliitis Induced Interface Fluid Syndrome 16 years After Laser in Situ Keratomileusis
Authors: Bough Matthew , Hwang Bryce , Santos Matthew , Syed Zeba A. 
Published: January 2025

Purpose:
To report a case of herpes simplex virus (HSV) endotheliitis inducing acute interface fluid syndrome in a patient with a remote history of laser in situ keratomileusis (LASIK).

Methods:
Case report and literature review.

Results:
A 51-year-old man with a history of LASIK 16 years prior presented with unilateral HSV endotheliitis and was found to have acute interface fluid syndrome secondary to endothelial decompensation. The patient was treated with oral valacyclovir 1 g 3 times daily, prednisolone acetate 1% drops 4 times daily, timolol maleate 0.5% drops twice daily, topical 5% sodium chloride hypertonic ophthalmic solution drops 4 times daily, and 5% sodium chloride hypertonic ophthalmic ointment nightly. At 1-month follow-up, the patient had full resolution of the interface fluid and returned to baseline visual acuity.

Conclusions:
This case underscores the importance of considering viral etiologies, such as HSV endotheliitis, in interface fluid syndrome beyond a decade after LASIK.
The Handmann line and its visual consequences after LASIK
Authors: Chua Nicolette Eunice T. , Tan Reginald Robert G. 
Published: January 2025

Introduction:
The purpose of this study was to describe the symptomatology, etiology, and management of a new type of dysphotopsia after laser-assisted in situ keratomileusis (LASIK).

Patient and Clinical Findings:
This report presents the case of a 32-year-old man who complained of new-onset bilateral vertical light streaks 9 years after LASIK. This was described as long, thick, vertical rays emanating from pinpoint light sources; more prominent in scotopic conditions; leaning toward the side of head tilt; and disappearing with eyelid fissure widening. There was no resolution with contact lenses or miotics. Corrected distance visual acuity was 6/6 with seemingly unremarkable corneas.

Diagnosis, Intervention, and Outcomes:
This photic phenomenon is related to eyelid position because of its distinct behavior. The upper eyelid imprints an arch line on the cornea, historically named “Handmann line,” which simulates a Maddox rod effect. Corneal epithelial mapping showed a sharp demarcation from the thinner superior epithelium covered by the upper eyelid vs the uncovered epithelium inferiorly. Scleral lenses were prescribed as barrier, which through time lessened the light streaks. Repeat epithelial mapping revealed a decreased epithelial thickness gradient on both eyes.

Conclusions:
Light streaks are a newly described visual phenomenon after LASIK brought about by the Handmann line. Management strategies should be aimed at minimizing pressure of the upper eyelid on the cornea.
Unveiling disparities in cancer care: a comparative study of service availability in low- and middle-income countries (LMICs) versus high-income countries (HICs)
Authors: Wang Ashley Wei-Ting , Bergerot Cristiane Decat , Bahcivan Ozan , Csaba Dégi L. , Kim Youngmee 
Published: January 2025

Abstract

Background:
Accessible supportive care is crucial for reducing unmet needs in cancer care and for improving cancer outcomes. However, significant disparities in supportive care resources exist between low- and middle-income countries (LMICs) and high-income countries (HICs). Health care priority is often set by health care professionals' (HCPs') evaluation about the adequacy of services and programs to meet their patients' needs. Thus, this study aimed to compare the perspectives of HCPs from LMICs versus HICs on the availability of supportive care services for patients with cancer and survivors (Aim 1). In addition, the study examined differences in service provision across four major age groups (Aim 2) and identified the types of services offered (Aim 3).

Methods:
Secondary analysis was conducted using the International Psycho-Oncology Society (IPOS) Survivorship Online Survey, targeting HCPs involved in clinical services and research with patients with cancer and survivors worldwide. The data from 177 (81 from LMICs and 96 from HICs) participants were subjected to subsequent analysis. Chi-squared tests were used to compare the availability of services for each of the 13 types of unmet needs overall and across four age groups and the types of services provided between LMICs and HICs.

Results:
HCPs from LMICs reported fewer services addressing patients' unmet needs related to sexuality/intimacy and financial concerns across all age groups and fewer services for various unmet needs (including symptom management, emotional distress, spiritual concerns, medical care, insomnia and fatigue, and personal care) of adolescents, young adults, and older adult patients, compared with HCPs from HICs. No significant differences were found between LMICs and HICs regarding service provision for middle-aged patients. Psychological counseling or psychotherapy was the most frequently provided service in both LMICs and HICs. However, HCPs from LMICs reported significantly fewer self-help materials and pharmacological services available but more support groups available for financial concerns and personal care.

Conclusions:
The study revealed significant disparities in the provision of supportive care services for patients with cancer between LMICs and HICs, highlighting the urgent need for targeted interventions and policy changes in LMICs. Future research should include broader geographical representation and focus on developing effective strategies to address critical unmet needs, particularly in sexuality/intimacy and financial concerns, to improve the quality of cancer care in LMICs.
Effect of fertility desire-based service on HIV seroconversion among serodiscordant partners: A 12-year retrospective cohort study
Authors: Yu Bin , Jike Chunnong , Lan Xiaomei , Wang Ju , Yu Gang , Yang Shujuan 
Published: January 2025

Background:
Fertility desire-based service guided by behavioral theory is a potential strategy to mitigate the HIV transmission risk, while related evidence remains scarce. We examined the long-term effect of theory-guided fertility desire-based services on HIV seroconversion between seropositive/seronegative partners in areas with high HIV prevalence and a cultural emphasis on fertility in China.

Methods:
We established a retrospective cohort by recruiting 8,653 seropositive partners with seronegative partners between January 1, 2009, and December 31, 2020, in Liangshan, China. The differences in HIV seroconversion between partners who received fertility desire-based services guided by the extended Information-Motivation-Behavioral Skills (IMB) model and those who did not were estimated, based on multivariable and inverse probability weighting (IPW) adjusted multivariable Cox regression models. Subgroup analysis was conducted based on participants’ demographic and HIV-related characteristics.

Results:
Among the 8,653 HIV-seropositive partners, 7,958 (92.0%) and their seronegative partners received fertility desire-based services. At the end of the 12-year follow up, 18 seronegative partners who did not receive fertility desire-based services experienced HIV seroconversion (incidence density: 7.4/1,000 person-years), while 98 seronegative partners receiving such services exhibited HIV seroconversion (3.4/1,000 person-years). Fertility desire-based services significantly reduced the risk of HIV seroconversion according to multivariable (HR=0.32, 95%CI: 0.19-0.53) and IPW-adjusted multivariable Cox regression models (HR=0.48, 95%CI: 0.27-0.84). The effect of fertility desire-based services was more pronounced in males and those above 40 years old.

Conclusions:
Fertility desire-based services based on the extended IMB model may help reduce the HIV transmission risk between seropositive/seronegative partners in areas with high HIV prevalence.
Differentiation of Atherosclerotic Carotid Plaque Components With Dual-Energy Computed Tomography
Authors: Aizaz Mueez , Bierens Juul , Gijbels Marion J.J. , Schreuder Tobien H.C.M.L. , van Orshoven Narender P. , Daemen Jan-Willem H.C. , Mess Werner H. , Flohr Thomas , van Oostenbrugge Robert J. , Postma Alida A. , Kooi M. Eline 
Published: January 2025

Objectives
Carotid plaque vulnerability is a strong predictor of recurrent ipsilateral stroke, but differentiation of plaque components using conventional computed tomography (CT) is suboptimal. The aim of our study was to evaluate the ability of dual-energy CT (DECT) to characterize atherosclerotic carotid plaque components based on the effective atomic number and effective electron density using magnetic resonance imaging (MRI) and, where possible, histology as the reference standard.

Materials and Methods
Patients with recent cerebral ischemia and a ≥2-mm carotid plaque underwent computed tomography angiography and MRI. A subgroup underwent carotid endarterectomy. Trained observers delineated plaque components on histology or MRI, independent of computed tomography angiography. DECT was coregistered with MRI and/or histology. Intraplaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), fibrous tissue, and calcifications were delineated on DECT, and ρeff and Zeff values were determined in the derivation cohort (n = 55). Spatial separation of these components was evaluated in a ρeff-Zeff-cluster plot. Ranges that optimally differentiate plaque features were determined. For validation, plaque components were quantified in the validation cohort (n = 29) using these ρeff-Zeff ranges and literature-based Hounsfield unit (HU) ranges and correlated to MRI volumes.

Results
Eighty-four participants (68 ± 8 years; 55 male) were evaluated. In the derivation cohort, plaque components were well separated on the cluster plot, resulting in the following ranges: IPH:ρeff < 1.15, Zeff < 7.5, LRNC:ρeff < 1.15, Zeff:7.5–8.75, fibrous tissue:ρeff < 1.15, Zeff > 8.75, and calcifications: ρeff > 1.15, Zeff > 0. In the validation cohort, significant correlations were found between ρeff-Zeff-based and MRI plaque volumes for fibrous tissue (r = 0.69, P < 0.001), LRNC (r = 0.94, P < 0.001), IPH (r = 0.35, P = 0.03), and calcifications (r = 0.70, P < 0.001). Lower correlations were found between HU-based and MRI plaque volumes for fibrous tissue (r = 0.40, P = 0.02), LRNC (r = 0.86, P < 0.001), and calcifications (r = 0.47, P = 0.005), with no correlation for IPH (r = 0.02, P = 0.45).

Conclusions
We determined ρeff-Zeff ranges for plaque assessment. ρeff-Zeff-based volumes showed strong-to-very strong correlations with MRI for LRNC, fibrous tissue, and calcifications and a weak correlation for IPH. ρeff-Zeff-based volumes demonstrated superior agreement with MRI for all plaque components compared with HU-based volumes, highlighting the potential of DECT for the identification of patients with vulnerable plaques.
Jannaschia maritima sp. nov., a novel marine bacterium isolated from the biofilm of concrete breakwater structures
Authors: Feng Hao , Liang Shuyi , Li Ruisi , Wang Hui , Cai Runlin 
Published: January 2025

Marine biofilms were newly revealed as a bank of hidden microbial diversity and functional potential. In this study, a Gram-stain-negative, aerobic, oval and non-motile bacterium, designated LMIT008T, was isolated from the biofilm of concrete breakwater structures located in the coastal area of Shantou, PR China. Strain LMIT008T was found to grow at salinities of 1–7% NaCl, at pH 5–8 and at temperatures 10–40 °C. Phylogenetic analysis based on 16S rRNA gene sequence indicated that strain LMIT008T belonged to the genus Jannaschia and was closely related to the type strains Jannaschia aquimarina KCTC23555T (96.03%) and Jannaschia marina SHC-163T (95.31%). The draft genome size of the strain LMIT008T was 3.67 Mbp, and the genomic DNA G+C content was 69.83 mol%. The average nucleotide identity value between strain LMIT008T and the closely related type strain J. aquimarina KCTC23555T was 74.82%. The predominant cellular fatty acids were identified as summed feature 8 (C18 : 1
ω7c/C18 : 1
ω6c) and C18 : 0, and the major polar lipids were phosphatidylethanolamine, phosphatidylglycerol and phosphatidylcholine. Ubiquinone-10 (Q-10) is the sole respiratory quinone. Further, genomic analysis of strain LMIT008T showed that the strain harbours abundant genes associated with biofilm formation and environmental adaption, explaining the potential strategies for living on concrete breakwater structures. Based on the morphological, phylogenetic, chemotaxonomic and phenotypic characterization, the strain LMIT008T was considered to represent a novel species in the genus of Jannaschia, for which the name Jannaschia maritima sp. nov. was proposed, with LMIT008T (=MCCC 1K08854T=KCTC 8321T) as the type strain.
Leukocyte Count Is Better than LDL-C as Predictor of Novel Carotid Atherosclerosis
Authors: Li Y , Cao H , Ding L , Naren T G , Zhang Q Q , Wang Z 
Published: January 2025

AbstractBackgroundThis continuous retrospective cohort study aims to(1)screen the risk factors and cut-off values of initial occurrence of carotid atherosclerosis(CAS) and(2)identify whether the pathological procession of CAS is from carotid intima-media thickening(C-IMT) to carotid plaques CAP).MethodsBetween 2015 and 2024, the characteristics were recorded at three time points, which were the meaningful time point for the first new appearance of CAS or not, the baseline time point for the previous closest normal carotid status, and the validated time point for the first confirming the meaningful results. Statistics analyses, including student’s t test, Mann-Whitney U test, and Chi-square test, assessed the different results between observation group and healthy controls. Logistic regression, Cox regression, ROC curves and Kaplan-Meier analysis were used for screening the risk factors and cut-off points. Repeated-measures ANOVA was used for comparison between the groups and within each group.ResultsOf 3583 recruited participants, the final study analyses included 1141 individuals, there was no significant change in the proportion of C-IMT and CAP during continuous observation of a 1.04 years (P=0.561). After performed Propensity score matching for age and gender, leukocyte count 5.00*109/L and low-density lipoprotein cholesterol (LDL-C) 125.1mg/dl were significantly associated with the new appearance of CAS over a 1.09 years follow-up period compared to the reference group. Leukocyte count high level group was associated with CAS (log-rank P=0.01), nevertheless LDL-C was no significant difference (log-rank P=0.055).ConclusionsMiddle aged adults(aged 49.6± 8.0)with leukocyte count above 5.00*109/L were more likely progress CAS after an average of 1.09 years. CAS new lesions had no obvious specificity and no significant changes were found after an average of 1.04 years. This study identified early specific markers that predict the appearance of CAS in order to guide the timing of early lifestyle interventions.
Inversions Dominate Evolution in the Highly Admixed European Sardine (Sardina pilchardus)
Authors: Sabatino SJ , Cabezas M. P , Pereira P , Garrido S , Múrias A , Carneiro M , Talhadas PJ , Louro B , Cox C , Canário AVM , Veríssimo A 
Published: January 2025

AbstractInversions can play key roles in the genetic architecture of adaptation, but the scale of their effects across different species remains poorly understood. Here, we use whole- genome sequencing to investigate the influence of inversions on the population genomics of the r-selected European sardine (Sardina pilchardus). Allele frequency differences from millions of SNPs across 34 populations spanning the species’ range were analyzed. Genomic scans identified several extreme outlier regions overlapping chromosome-scale inversions, collectively representing over half the genome. Our findings suggest these inversions are associated with locally adapted life history strategies. First, SNPs within outlier regions containing inversions exhibited striking allele frequency differences between Atlantic and Mediterranean sardines, which differ in key adaptive life history traits. In the Atlantic, inversion allele frequencies varied latitudinally, while in the Mediterranean, they shifted longitudinally, aligning with temperature and oceanographic features that influence sardine life history strategies. Moreover, adjacent populations in contrasting environments displayed pronounced allele frequency differences in inversions. These spatial patterns of allele frequencies sharply contrasted with those based on neutral loci, indicating they are driven by selection. After rigorously filtering SNPs affected by selection and inversions, sardine populations showed high admixture across their range but significant population structure and isolation by distance, especially in the Mediterranean. This study demonstrates that inversions can shape genome-wide patterns of genetic diversity and population structure in highly admixed r-selected marine species. These findings also offer crucial insights for stock delimitation and management of this commercially valuable species in the face of climate change.