bluuebunny/crossref_metadata_2025_split huggingface dataset:
The adaptive evolution of cold‐activated TRPM8 in wildlife vertebrates
Authors: Lu Xiancui , Wu Jiayi , Shi Longyan , Zhou Yi , Su Yuqing , Wang Yunfei , Yang Shilong 
Published: March 2023

AbstractTemperature influences all biological processes. In wild animals, the evolution of molecular thermosensors is crucial in ambient temperature adaption and habitat selection with species specificity. The transient receptor potential melastatin 8 (TRPM8, the most established cold receptor expressed in thermosensory nerve endings) is a cation permeable ion channel, which plays a critical role in thermal sensation and adaptation. The transition of TRPM8 from the closed to open state can be attributed to strong cold dependence. Comparative studies of TRPM8 orthologs have provided valuable insights into how thermosensation has evolved in wild vertebrates over time. Specifically, the appearance of the trpm8 gene in lungfishes provided a protogene structure without function. During the water‐to‐land transition, the trpm8 protogene accumulated mutations mainly in the MHR1‐3 domain that confer cold sensitivity to TRPM8 proteins of terrestrial vertebrates. Furthermore, trpm8 in terrestrial vertebrates acquired mutations at the pore domain that resulted in a change in cold activation efficacy at the molecular level. In marine mammals, TRPM8 orthologs are cold‐sensitive, based on the expectation that the MHR1‐3 domain and pore domain are consistent with those of terrestrial mammals. This review discusses the relationship between the biophysical properties of TRPM8 cold activation and ambient temperature adaptation in vertebrates.
Teacher Education of the Future: Trends and Possible Scenarios in the Nordic Context
Authors: Elstad Eyvind 
Published: March 2023

AbstractThis chapter uses current trends to outline possible scenarios in teacher education programmes in the Nordic countries. The starting point is that, aside from Finnish teacher education, teacher education programmes in Nordic countries have almost never been considered genuinely excellent. Therefore, teacher education has become a policy problem. As the developmental features of today’s teacher education in the Nordic region are deeply complex and partly characterized by inherent tensions between contradictory considerations, making predictions is a daunting task. There is considerable diversity among teacher education programmes in Nordic countries, and future developments might take several paths. Therefore, one cannot talk about a single current or future model for Nordic teacher education.Several premises for discussing the future of teacher education are considered in this chapter, including the idea of a knowledge economy and an emphasis on equality values. Policy-making is often set within general critical discourse about teaching and teacher education. The question is how teacher education institutions will respond to the various challenges that exist. In this chapter, trends and possible scenarios for teacher education in the Nordic context are discussed on the basis of a complex theoretical framework.
The Evolution of the Extended Comprehensive School Model and the Modern Profession-Oriented Teacher Education After World War II
Authors: Elstad Eyvind 
Published: March 2023

AbstractDespite the fact that the Nordic countries had very different experiences during World War II, cooperation intensified in the 1950s. The Nordic school model, with its emphasis on the child in focus, inclusion, equal opportunities for all, and an extended comprehensive and undifferentiated school system, emerged. The sorting of pupils into different tracks took place at age 15 or 16. The 1960s saw a significant expansion of the education systems, with the Swedish school model emerging as a paradigm for the other Nordic countries. With Finland’s success in the first comparative education studies, Finnish teacher education became the standard for teacher education in Iceland and Norway. Sweden follows more complex models for teacher education, while Danish teacher education is an outlier from a Nordic comparison perspective. While Finnish teacher education has shown stability, frequent changes in models of teacher education in the other Nordic countries are typical. In public discourse, crises in teacher education are a recurring theme. These crises concern criticism of the quality of applicants, what student teachers learn, and insufficient graduate production. The problems facing teacher education are varied, but where they occur, they are dire; there are no simple solutions to the challenges that currently exist.
Erzählstrategien
Authors: Stübe Raphael 
Published: March 2023

ZusammenfassungSo unterschiedlich die Diskurse über eine neue Romantik auch ausfallen, so lassen sich auf einer literarischen Ebene wiederkehrende Momente beobachten, mit denen Romantik um 1900 aufgegriffen und aktualisiert wird. Heinrich Mann, Hanns Heinz Ewers und Hermann Hesse repräsentieren drei unterschiedliche Spielarten einer Neoromantik, die mit jeweils verschiedenen Argumenten und in heterogenen Phasen betrieben wird. Dennoch zeigen die frühen Prosatexte dieser Autoren strukturelle Gemeinsamkeiten, sobald man auf ihre Remodellierung des Romantischen achtet. Die Perspektivenvielfalt zum Beispiel, mit der romantische Texte noch einen absoluten Fluchtpunkt umkreisen, weicht hier einer Tendenz zur Monoperspektivität, in der exotische Figuren einzelne Subbereiche des ‚Lebens‘ entschlüsseln. Mikroskopische Einzelgesetze dieser Art können mit den Blicken der Außenseiter durchdrungen werden, scheitern jedoch daran, in die Gesellschaft zurückübersetzt zu werden. Exkurse zur Idiosynkrasie der Routines, zum Lebensmonismus und zu den Autorinnen binden die Neoromantik an die aktuellen Forschungsdiskurse zurück.
Schedulability Analysis of Mixed-Criticality Data Under Fixed-Priority Scheduling
Authors: Jin Xi , Xia Changqing , Xu Chi , Li Dong 
Published: March 2023

AbstractWirelessHART, as a robust and reliable wireless protocol, has been widely-used in industrial systems. Its real-time performance has been extensively studied, but limited to the single-criticality case. Many advanced applications have mixed-criticality communications, where different data flows come with different criticality levels. Hence, in this chapter, we study the real-time mixed-criticality communication based on WirelessHART networks, and present an end-to-end delay analysis method under fixed priority scheduling.
Identification of a key locus, qNL3.1, associated with seed germination under salt stress via a genome-wide association study in rice
Authors: Zhan Chengfang , Zhu Peiwen , Chen Yongji , Chen Xinyi , Liu Kexin , Chen Shanshan , Hu Jiaxiao , He Ying , Xie Ting , Luo Shasha , Yang Zeyuan , Chen Sunlu , Tang Haijuan , Zhang Hongsheng , Cheng Jinping 
Published: March 2023

Abstract
Key message
Two causal OsTTL and OsSAPK1genes of the key locus qNL3.1 significantly associated with seed germination under salt stress were identified via a genome-wide association study, which could improve rice seed germination under salt stress.

Abstract
Rice is a salt-sensitive crop, and its seed germination determines subsequent seedling establishment and yields. In this study, 168 accessions were investigated for the genetic control of seed germination under salt stress based on the germination rate (GR), germination index (GI), time at which 50% germination was achieved (T50) and mean level (ML). Extensive natural variation in seed germination was observed among accessions under salt stress. Correlation analysis showed significantly positive correlations among GR, GI and ML and a negative correlation with T50 during seed germination under salt stress. Forty-nine loci significantly associated with seed germination under salt stress were identified, and seven of these were identified in both years. By comparison, 16 loci were colocated with the previous QTLs, and the remaining 33 loci might be novel. qNL3.1, colocated with qLTG-3, was simultaneously identified with the four indices in two years and might be a key locus for seed germination under salt stress. Analysis of candidate genes showed that two genes, the similar to transthyretin-like protein OsTTL and the serine/threonine protein kinase OsSAPK1, were the causal genes of qNL3.1. Germination tests indicated that both Osttl and Ossapk1 mutants significantly reduced seed germination under salt stress compared to the wild type. Haplotype analysis showed that Hap.1 of OsTTL and Hap.1 of OsSAPK1 genes were excellent alleles, and their combination resulted in high seed germination under salt stress. Eight accessions with elite performance of seed germination under salt stress were identified, which could improve rice seed germination under salt stress.
Neighbourhood cohesion, loneliness and perceived social isolation prior and during the COVID-19 pandemic. Longitudinal evidence from the German Ageing Survey
Authors: Hajek André , Kretzler Benedikt , Walther Carolin , Aarabi Ghazal , Zwar Larissa , König Hans-Helmut 
Published: March 2023

Abstract
Purpose
To investigate the longitudinal association between neighbourhood cohesion and loneliness as well as perceived social isolation prior and during the COVID-19 pandemic (stratified by sex).

Methods
Longitudinal data were taken from a nationally representative sample (German Ageing Survey) of inhabitants aged 40 years and over in Germany prior (wave 6: year 2017) and during the COVID-19 pandemic (wave 8: November 2020 until February 2021; n = 6688 observations, mean age was 67.4 years). The De Jong Gierveld tool was used to measure loneliness and the Bude and Lantermann tool was used to measure perceived social isolation. Neighbourhood cohesion was assessed based on different items.

Results
FE regressions showed that decreases in closeness of contact with neighbours were associated with increases in loneliness and perceived social isolation levels among men, but not women. In contrast, decreases in different indicators of involvement in neighbourhood activities were associated with increases in loneliness and perceived social isolation levels among women, but not men.

Conclusion
Changes in neighbourhood factors are differently associated with loneliness and perceived social isolation among middle-aged and older women and men. Gender-specific efforts to avoid loneliness and social isolation are, therefore, needed.
Adjustment of the geometries of the cutting front and the kerf by means of beam shaping to maximize the speed of laser cutting
Authors: Lind Jannik , Hagenlocher Christian , Weckenmann Niklas , Blazquez-Sanchez David , Weber Rudolf , Graf Thomas 
Published: March 2023

AbstractThe shape of the laser beam used for fusion cutting significantly influences the geometry of both the cutting front and the cutting kerf. The angle of the cutting front in turn impacts the local absorptivity, while the width of the kerf defines the amount of material, which has to be molten. The kerf’s geometry therefore determines the maximum possible cutting speed at which a successful cut is feasible with a given available laser power. The absorptivity, the width of the kerf, and the maximum possible cutting speed can be estimated from a simple model considering the conservation of energy and rough geometrical approximations. In order to verify the prediction of the model, the geometry of the cutting front and kerf resulting from different processing conditions was observed by means of online high-speed X-ray diagnostics. The geometry of the interaction zone was recorded with a framerate of 1000 Hz during fusion cutting of 10-mm-thick samples of stainless steel. Comparing the results obtained with different shapes of the laser beam, it was found that the absorptivity is increased when the beam’s longitudinal cross-section (parallel to the feed) is enlarged. Reducing the width of the beam in the transversal direction normal to the feed reduces the cross-sectional area of the cutting kerf. The findings show a good agreement with the geometric model which enabled the prediction of the absorptivity and the cross-sectional area of the cutting kerf and hence allows to reliably estimate the maximum cutting speed for different shapes of the laser beam, laser power, and sheet thicknesses.
Graphical characterizations of robust stability in biological interaction networks
Authors: Al-Radhawi M. Ali 
Published: March 2023

AbstractPrevious studies have inferred robust stability of reaction networks by utilizing linear programs or iterative algorithms. Such algorithms become tedious or computationally infeasible for large networks. In addition, they operate like black boxes without offering intuition for the structures that are necessary to maintain stability. In this work, we provide several graphical criteria for constructing robust stability certificates, checking robust non-degeneracy, verifying persistence, and establishing global stability. By characterizing a set of stability-preserving graph modifications that includes the enzymatic modification motif, we show that the stability of arbitrarily large nonlinear networks can be examined by simple visual inspection. We show applications of this technique to ubiquitous motifs in systems biology such as post-translational modification (PTM) cycles, the ribosome flow model (RFM),T-cell kinetic proofreading, and others. The results of this paper are dedicated in honor of Eduardo D. Sontag’s seventieth birthday and his pioneering work in nonlinear dynamical systems and mathematical systems biology.
Integrated transcriptomics and metabolomics analysis reveals the biomolecular mechanisms associated to the antitumoral potential of a novel silver-based core@shell nanosystem
Authors: Aragoneses-Cazorla Guillermo , Vallet-Regí María , Gómez-Gómez Ma. Milagros , González Blanca , Luque-Garcia Jose L. 
Published: March 2023

AbstractA combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for the antitumor action of a nanosystem based on a Ag core coated with mesoporous silica on which transferrin has been anchored as a targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis has been carried out by gene microarrays and RT-qPCR, while high-resolution mass spectrometry has been used for metabolomics. This multi-omics strategy has enabled the discovery of the effect of this nanosystem on different key molecular pathways including the glycolysis, the pentose phosphate pathway, the oxidative phosphorylation and the synthesis of fatty acids, among others.Graphical Abstract
Neue epilepsiechirurgische Techniken und intraoperatives Monitoring bei nichtläsioneller MRT-negativer Epilepsie
Authors: Rössler Karl , Dorfer Christian 
Published: March 2023

ZusammenfassungDurch die Einführung moderner Techniken für die neurochirurgische Intervention bei nichtläsionellen (NL) MRT-negativen medikamentös therapierefraktären Epilepsien (temporal, aber v. a. auch extratemporal) zeigte sich im letzten Jahrzehnt sowohl bei Kindern und Adoleszenten als auch bei Erwachsenen eine deutliche Zunahme diese Eingriffe um etwa 10–15 % [1]. Für die prächirurgische Evaluation von NL-Epilepsien ist das invasive Monitoring zur Diagnostik einer fokalen Epilepsie bzw. zur Definition der potenziellen epileptogenen Zone für eine mögliche Resektion oder Ablation – insbesondere extratemporal – wünschenswert. Die Technik der invasiven Abklärung von NL-Epilepsien hat im letzten Jahrzehnt eine grundsätzliche Strategieänderung erfahren, weg von über eine Kraniotomie eingebrachten subduralen Elektroden, hin zum weniger invasiven Stereo-EEG (sEEG) mit Tiefenelektroden. Das minimal-invasive und weniger komplikationsbehaftete sEEG kann auch tief gelegene Anfallsgeneratoren und unter Einbeziehung von künstlicher Intelligenz (AI) auch sterische Ausdehnung der potenziellen epileptogenen Zone darstellen, was für eine mögliche Resektion bei nichtläsionellen Epilepsien Voraussetzung ist. In sprachrelevanten Kortexarealen bleiben allerdings das Monitoring und Mapping mit Subduralelektroden alternativlos. Gleichzeitig ermöglichen neue Techniken in der Neurochirurgie wie Neuronavigation, Neuromonitoring (IONM) und intraoperative MR-Bildgebung, Robotik und Laserablation (LITT) die Schonung von eloquenten Hirnarealen in der Nachbarschaft der epileptogenen Zone. Zusätzlich können neuerdings traditionelle Techniken (Elektrokortikographie (ECoG) und Neuromonitoring (IONM)) mit der Bildgebung direkt durch Dateneinspiegelung ins Operationsmikroskop in den operativen Situs zur Resektion miteinbezogen werden. Diese Entwicklungen haben dazu geführt, dass für immer mehr NL-fokale Epilepsien die Resektion möglich ist und dass sich das postoperative Epilepsie-Outcome von NL-Epilepsien deutlich verbessert hat.
Mink on the brink: comparing survey methods for detecting a critically endangered carnivore, the European mink Mustela lutreola
Authors: Croose Elizabeth , Hanniffy Ruth , Harrington Andrew , Põdra Madis , Gómez Asun , Bolton Polly L. , Lavin Jenna V. , Browett Samuel S. , Pinedo Javier , Lacanal David , Galdos Iñaki , Ugarte Jon , Torre Aitor , Wright Patrick , MacPherson Jenny , McDevitt Allan D. , Carter Stephen P. , Harrington Lauren A. 
Published: March 2023

AbstractMonitoring rare and elusive species is critical in guiding appropriate conservation management measures. Mammalian carnivores are challenging to monitor directly, due to their generally nocturnal and solitary lifestyle, and relatively large home ranges. The European minkMustela lutreolais a critically endangered, small, semi-aquatic carnivore and is one of the most threatened mammal species in Europe. In northern Spain, the European mink population is monitored regionally using different methods and approaches, making assessment of national population status difficult. There is an urgent need to 1) assess the efficacy of survey methods and 2) identify a standard monitoring methodology that can be deployed rapidly and inexpensively over large areas of the mink’s range. We deployed four methods—camera trapping, hair tubes, live trapping, and environmental DNA (eDNA) from water samples—to compare the probability of detecting European mink when present at 25 sampling sites within five 10 × 10 km2, and the economic cost and time required for each method. All four methods successfully detected European mink but the probability of detection varied by method. Camera trapping and hair tubes had the highest probability of detection; however, eDNA and live trapping detected mink in one 10 × 10 km2where the latter two methods did not. For future European mink monitoring programs, we recommend a combination of at least two methods and suggest that camera traps or hair tubes are combined with live trapping or eDNA (depending on the scale and aims of the study), to gather critical information on distribution, occupancy and conservation status.
Anticancer effect of zanubrutinib in HER2-positive breast cancer cell lines
Authors: Dostálová Hana , Jorda Radek , Řezníčková Eva , Kryštof Vladimír 
Published: March 2023

AbstractSmall molecule Bruton’s tyrosine kinase (BTK) inhibitors have been developed for the treatment of various haemato-oncological diseases, and ibrutinib was approved as the first BTK inhibitor for anticancer therapy in 2013. Previous reports proved the receptor kinase human epidermal growth factor receptor 2 (HER2) to be a valid off-target kinase of ibrutinib and potentially other irreversible BTK inhibitors, as it possesses a druggable cysteine residue in the active site of the enzyme. These findings suggest ibrutinib as a candidate drug for repositioning in HER2-positive breast cancer (BCa). This subtype of breast cancer belongs to one of the most common classes of breast tumours, and its prognosis is characterized by a high rate of recurrence and tumour invasiveness. Based on their similar kinase selectivity profiles, we investigated the anticancer effect of zanubrutinib, evobrutinib, tirabrutinib and acalabrutinib in different BCa cell lines and sought to determine whether it is linked with targeting the epidermal growth factor receptor family (ERBB) pathway. We found that zanubrutinib is a potential inhibitor of the HER2 signalling pathway, displaying an antiproliferative effect in HER2-positive BCa cell lines. Zanubrutinib effectively inhibits the phosphorylation of proteins in the ERBB signalling cascade, including the downstream kinases Akt and ERK, which mediate key signals ensuring the survival and proliferation of cancer cells. We thus propose zanubrutinib as another suitable candidate for repurposing in HER2-amplified solid tumours.
Spatial and temporal patterns of stream nutrient limitation in an Arctic catchment
Authors: Hauptmann Demian , Myrstener Maria 
Published: March 2023

AbstractArctic stream biofilm responses to ongoing climate-related changes in physical and chemical conditions have major implications for stream food webs and biogeochemical cycles. Yet, such effects have rarely been studied outside summer months or at sub-catchment scales in the Arctic. We used deployments of nutrient diffusing substrates (NDS) to assess the spatial (20 deployments) and seasonal patterns (10 deployments) and physical and chemical drivers of nutrient limitation within an Arctic stream catchment. Results show that nutrient limitation of autotrophic processes was common during summer, but that light inhibited biomass accrual under the ice in winter. Alongside single N, P and C responses, co-limitation dominated the overall pattern of limitation over time and across the catchment. However, the primary limiting nutrient to autotrophs changed from N to P in parts of the catchment with higher N concentrations. As Arctic studies are often conducted at individual sites during summer, these may miss shifts in the drivers of stream productivity that arise from variable nutrient, temperature, and light regimes. Our results caution against focusing on one single most important limiting nutrient, as we found that this can shift seasonally and over small spatial scales in this Arctic catchment.
The green investment principles: from a nodal governance perspective
Authors: Cheng Wenting 
Published: March 2023

AbstractChina’s Belt and Road Initiative is now the world’s largest infrastructure initiative, with long-term climate change effects, and the Green Investment Principles (GIPs) for Belt and Road have been promoted as a key instrument to green the Belt and Road. This article focuses on the question: What role do the GIPs play in building a green Belt and Road and addressing relevant regulatory challenges? Based on the theory of nodal governance, it is argued that the GIPs’ two-layered networks facilitate China to influence investment decisions over many countries along the Belt and Road indirectly through fund providers as key nodes to transition toward green investment. China also avoided direct interference with the domestic policies of host countries through the GIP network. As a framework agreement, the GIPs also provide opportunities for signatories to contribute to the design and negotiation of specific implementation standards, enhanced capacity building, and the prospect of more stringent and prescriptive environmental standards in the future.
Aggregative Variational Inequalities
Authors: von Mouche Peter Hubert Mathieu , Szidarovszky Ferenc 
Published: March 2023

AbstractWe enrich the theory of variational inequalities in the case of an aggregative structure by implementing recent results obtained by using the Selten–Szidarovszky technique. We derive existence, semi-uniqueness and uniqueness results for solutions and provide a computational method. As an application we derive very powerful practical equilibrium results for Nash equilibria of sum-aggregative games and illustrate with Cournot oligopolies.