bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Constant-wavelength Concurrent Selective Fluorescence Method for Assay of Ibuprofen and Chlorzoxazone in Presence of Chlorzoxazone Degradation Product
Authors: Abdallah Nora A. , Fathy Mona E. , Tolba Manar M. , El-Brashy Amina M. , Ibrahim Fawzia A. 
Published: February 2023

AbstractLower back pain is a universal dilemma leaving a negative effect on both health and life quality. It was found that a fixed dose combination of chlorzoxazone and ibuprofen gave a higher efficiency than analgesic alone in treatment of acute lower back pain. Based on the significant benefit of that combination, a green, sensitive, rapid, direct, and cost-effective method is created for concurrent determination of ibuprofen and chlorzoxazone in presence of 2-amino para chlorophenol (a synthetic precursor and potential impurity of chlorzoxazone) adopting the synchronous spectrofluorimetric technique. Synchronous spectrofluorimetric technique is adopted to avoid the highly overlapped native spectra of both drugs. The synchronous spectrofluorometric method was applied at Δλ = 50 nm, ibuprofen was measured at 227 nm while chlorzoxazone was measured at 282 nm with no hindering from one to another. The various experimental variables affecting the performance of the suggested technique were explored and adjusted. The suggested technique showed good linearity from 0.02 to 0.6 and 0.1 to 5.0 µg/mL for ibuprofen and chlorzoxazone, respectively. The produced detection limits were 0.27 × 10–3and 0.03, while the quantitation limits were 0.82 × 10–3and 0.09 µg/mL for ibuprofen and chlorzoxazone, respectively. The suggested approach was successfully applied for the analysis of the studied drugs in the synthetic mixture, different pharmaceutical preparations, and spiked human plasma. The suggested technique was validated with respect to the International Council of Harmonization (ICH) recommendations. The suggested technique was found to be simpler and greener with lower cost compared to the earlier reported methods which required complicated techniques, longer time of analysis, and less safe solvents and reagents. Green profile assessment for the developed method compared with the reported spectrofluorometric method was performed using four assessment tools. These tools confirmed that the recommended technique attained the most possible green parameters, so it could be used as a greener option in routine quality control for analyzing the two drugs in genuine form and pharmaceutical preparations.
Second-Order Symmetric Duality for Multiple Objectives Nonlinear Programming Under Generalizations of Cone-Preinvexity Functions
Authors: Kassem Mohamed Abd El-Hady 
Published: February 2023

AbstractIn this article, we present generalizations of the cone-preinvexity functions and study a pair of second-order symmetric solutions for multiple objective nonlinear programming problems under these generalizations of the cone-preinvexity functions. In addition, we establish and prove the theorems of weak duality, strong duality, strict converse duality, and self-duality by assuming the skew-symmetric functions under these generalizations of the cone-preinvexity functions. Finally, we provide four nontrivial numerical examples to demonstrate that the results of the weak and strong duality theorems are true.
Unpacking an affordance-based model of chronic pain: a video game analogy
Authors: Coninx Sabrina , Ray B. Michael , Stilwell Peter 
Published: February 2023

AbstractChronic pain is one of the most disabling medical conditions globally, yet, to date, we lack a satisfying theoretical framework for research and clinical practice. Over the prior decades, several frameworks have been presented with biopsychosocial models as the most promising. However, in translation to clinical practice, these models are often applied in an overly reductionist manner, leaving much to be desired. In particular, they often fail to characterize the complexities and dynamics of the lived experience of chronic pain. Recently, an enactive, affordance-based approach has been proposed, opening up new ways to view chronic pain. This model characterizes how the persistence of pain alters a person’s field of affordances: the unfolding set of action possibilities that a person perceives as available to them. The affordance-based model provides a promising perspective on chronic pain as it allows for a systematic investigation of the interactive relation between patients and their environment, including characteristic alterations in the experience of their bodies and the space they inhabit. To help bridge the gap from philosophy to clinical practice, we unpack in this paper the core concepts of an affordance-based approach to chronic pain and their clinical implications, highlighting aspects that have so far received insufficient attention. We do so with an analogy to playing video games, as we consider such comparative illustration a useful tool to convey the complex concepts in an affordance-based model and further explore central aspects of the lived experience of chronic pain.
Qualities of consent: an enactive approach to making better sense
Authors: Vassilicos Basil , McGann Marek 
Published: February 2023

AbstractPhilosophical work on the concept of consent in the past few decades have got to grips with it as a rich notion. We are increasingly sensitive to consent not as a momentary, atomic, transactional thing, but as a complex idea admitting of various qualities and dimensions. In this paper we note that the recognition of this complexity demands a theoretical framework quite different to those presently extant, and we suggest that the enactive approach is one which offers significant value in this regard. In consonance with arguments made by Laurie Penny about how consent is a continuous and dynamic process, we outline how an enactive approach identifies consent as temporally extended (rather than momentarily transactional), and as affected by the skilfulness of the agents involved, the fitness of community-provided resources to negotiate the consensual relationship over time, and the unfolding of circumstances in the situation in which the joint action is taking place. We argue that the value of an enactive perspective on consent is in highlighting these complexities, and in providing resources to articulate and theorise them in ways that are not open to other current approaches.
Synthetic indicators to analyze work-related physical and psychosocial risk factors: evidence from the European Working Conditions Survey
Authors: Capecchi Stefania , Cappelli Carmela , Curtarelli Maurizio , Di Iorio Francesca 
Published: February 2023

AbstractIn modern workplaces, alongside physical, chemical, and biological hazards, other risks are linked to the organisation of work and to the nature of the work itself. This paper investigates the association between workers’ well-being and both psychosocial and physical risk factors at work proposing a synthetic measure suitable to generate insights on well-being at work and on individual risk factors. Exploiting data from the European Working Conditions Survey, we select as response variable the “self-assessed health”. As this proxy of well-being is measured on a Likert scale, Ordered Probit analyses are run, and respondents’ profiles are illustrated. Then, a Principal Component Analysis is carried out to build two synthetic measures summarising the selected risk determinants. The resulting first principal components are subsequently used as synthetic indicators in further, simplified, Ordered Probit models to explain the impact of different sets of risks on perceived health. Such a methodology allows for a straightforward interpretation of the results since many different risk drivers are replaced by two continuous synthetic indicators. Our findings, in line with existing research, confirm that both types of risk factors do exert a substantial impact on workers’ health, although the psychosocial determinants seem to be more prominent.
Seasonality and the female happiness paradox
Authors: Blanchflower David G. , Bryson Alex 
Published: February 2023

AbstractMost studies tracking wellbeing do not collect data across all the months in a year. This leads to error in estimating gender differences in wellbeing for three reasons. First, there are seasonal patterns in wellbeing (particularly life satisfaction and happiness) which are gendered, so failure to account for those confounds estimates of gender differences over time. Second, studies fielded in discrete parts of the year cannot extrapolate to gender differences in other parts of the year. Making inferences about trends over time is particularly problematic when a survey changes its field survey dates across years. Third, without monthly data, surveys miss big shifts in wellbeing that occur for short periods. This is a problem because women’s wellbeing is more variable over short periods of time than men’s wellbeing. It also bounces back faster. We show that simply splitting the data by months in a happiness equation generates a positive male coefficient in one subset of months from September to January and a negative coefficient in months February to August. Such a split has no impact on the male coefficients in an anxiety equation. Months matter.
Treatment of localized prostate cancer in elderly patients: the role of partial cryoablation
Authors: Selvaggio Oscar , Finati Marco , Falagario Ugo Giovanni , Silecchia Giovanni , Recchia Marco , Checchia Andrea Alberto , Milillo Paola , Sanguedolce Francesca , Cindolo Luca , Busetto Gian Maria , Bettocchi Carlo , Cormio Luigi , Carrieri Giuseppe 
Published: February 2023

Abstract
Purpose
To evaluate oncological outcomes of partial gland cryoablation (PGC) for localized prostate cancer (PCa) in a cohort of elderly patients who required an active treatment.

Methods
Data from 110 consecutive patients treated with PGC for localized PCa were collected. All patients underwent the same standardized follow-up with serum-PSA level and digital rectal examination. Prostate MRI and eventual re-biopsy were performed at twelve months after cryotherapy or in case of suspicion of recurrence. Biochemical recurrence was defined according to Phoenix criteria (PSA nadir + 2 ng/ml). Kaplan–Meier curves and Multivariable Cox Regression analyses were used to predict disease progression, biochemical recurrence- (BCS) and additional treatment-free survival (TFS).

Results
Median age was 75 years (IQR 70–79). PGC was performed in 54 (49.1%) patients with low-risk PCa, 42 (38.1%) with intermediate risk and 14 (12.8%) high risk. At a median follow-up of 36 months, we recorded a BCS and TFS of 75 and 81%, respectively. At 5 years, BCS was 68.5% and CRS 71.5%.
High-risk prostate cancer was associated with lower TFS and BCS curves when compared with low-risk group (all p values < .03). A PSA reduction < 50% between preoperative level and nadir resulted as an independent failure predictor for all outcomes evaluated (all p values < .01). Age was not associated with worse outcomes.

Conclusions
PGC could be a valid treatment for low- to intermediate PCa in elderly patients, when a curative approach is suitable in terms of life expectancy and quality of life.
Long-Term Water Management Model for Preserving Sustainable Useful Capacity of Reservoirs
Authors: Molino Bruno , De Vincenzo Annamaria , Minó Antonio , Ambrosone Luigi 
Published: February 2023

AbstractIn this study, we present a long-term water management model which can be an important tool for the ordinary management of a reservoir. The model can be made simple and applicable in a graphic form. The key point of the model is that the sedimentation rate of solids can be modeled according to a power law. The basic equation of the model is tested using bathymetric surveys of different dams located in different parts of the world. Robustness and predictive power are evaluated both numerically and by comparison with satellite results. Then the model is transformed into the form of a management plot and applied to the real case of the Camastra dam.
A comprehensive study for Al2O3 nanofluid cooling effect on the electrical and thermal properties of polycrystalline solar panels in outdoor conditions
Authors: Ibrahim Ali , Ramadan Muhammad Raafat , Khallaf Abd EL-Monem , Abdulhamid Muhammad 
Published: February 2023

Abstract
Photovoltaic (PV) technology is considered one of the most effective and promising renewable sources of energy. The PV system’s efficiency strongly depends on its operating temperature, which acts as a defect to the electrical efficiency by increasing over 25 °C. In this work, a comparison was performed between three traditional polycrystalline solar panels simultaneously at the same time and under the same weather conditions. The electrical and thermal performances of the photovoltaic thermal (PVT) system integrated with a serpentine coil configured sheet with a plate thermal absorber setup are evaluated using water and aluminum oxide nanofluid. For higher mass flow rates and nanoparticle concentrations, an improvement in the PV modules short-circuit current (Isc) and open-circuit voltage (Voc) yield and electrical conversion efficiency is achieved. The enhancement in the PVT electrical conversion efficiency is 15.5%. For 0.05% volume concentration of Al2O3 and flow rate of 0.07 kg/s, an enhancement of 22.83% of the temperature of PVT panels’ surface over the reference panel has been obtained. An uncooled PVT system reached a maximum panel temperature of 75.5 °C at noontime and obtained an average electrical efficiency of 12.156%. Water and nanofluid cooling reduce the panel temperature by 10.0 °C and 20.0 °C at noontime, respectively.
Copper toxicity leads to accumulation of free amino acids and polyphenols in Phaeodactylum tricornutum diatoms
Authors: Santiago-Díaz Paula , Rivero Argimiro , Rico Milagros , González González Aridane , González-Dávila Melchor , Santana-Casiano Magdalena 
Published: February 2023

AbstractThis work is focused on the effect of lethal and sub-lethal copper (Cu) concentrations on the free amino acid and polyphenol production by the marine diatom Phaeodactylum tricornutum (P. tricornutum) after 12, 18, and 21 days of exposure. The concentrations of 10 amino acids (arginine, aspartic acid, glutamic acid, histidine, lysine, methionine, proline, valine, isoleucine, and phenylalanine) and 10 polyphenols (gallic acid, protocatechuic acid, p-coumaric acid, ferulic acid, catechin, vanillic acid, epicatechin syringic acid, rutin, and gentisic acid) were measured by RP-HPLC. Under lethal doses of Cu, free amino acids reached levels significantly higher than those in the control cells (up to 21.9 times higher), where histidine and methionine showed the highest increases (up to 37.4 and 65.8 times higher, respectively). The total phenolic content also increased up to 11.3 and 5.59 times higher compared to the reference cells, showing gallic acid the highest increase (45.8 times greater). The antioxidant activities of cells exposed to Cu were also enhanced with increasing doses of Cu(II). They were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability (RSA), cupric ion reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays. Malonaldehyde (MDA) exhibited the same tendency: cells grown at the highest lethal Cu concentration yielded the highest MDA level. These findings reflect the involvement of amino acids and polyphenols in protective mechanisms to overcome the toxicity of copper in marine microalgae.
Graphical Abstract
Surgery assistance system for continuous resection of brain tumors-proposal of continuous tumor resection forceps, tumor cell separation, dehydration, and isolation mechanism
Authors: Koguchi Taro , Shimizu Funika , Nagame Tomohiro , Goto Yuka , Iwasaki Hikaru , Hanafusa Akihiko , Takagi Motoki , Mohamaddan Shahrol , Nomura Kenichi , Muragaki Yoshihiro , Iseki Hiroshi , Masamune Ken , Akitaya Toyohisa 
Published: February 2023

AbstractThe tumor resection ratio must be improved due the increased possibility of recurrence or malignancy. The purpose of this study was to develop a system that includes forceps with a continuous suction function and flow cytometry to diagnose the malignancy of the tumor for safe, accurate, and effective surgery. A newly developed continuous tumor resection forceps consists of a triple pipe structure, which enables continuous suction of the tumor by integrating the reflux water and suction system. The forceps includes tip opening/closure detection switch to control the adsorption and suction strength when tip is opened and closed. To perform accurate tumor diagnosis using flow cytometry, a filtering mechanism was developed for dehydrating reflux water from continuous suction forceps. In addition, a cell isolation mechanism comprising a roller pump and shear force loading mechanism was also newly developed. By using a triple pipe structure, a significantly larger tumor collection ratio was observed compared to the previous double-pipe structure. By performing suction pressure control with the opening/closure detection switch, inaccurate suction can be prevented. By widening the filter area of dehydration mechanism, it was possible to improve the reflux water dehydration ratio. The most appropriate filter area was 85 mm2. By using a newly developed cell isolation mechanism, the processing time can be reduced to less than 1/10 of the original time, keeping the same cell isolation ratio, when compared to the existing pipetting method. Neurosurgery assistance system with continuous tumor resection forceps and a cell separation, dehydration and isolation mechanism was developed. An effective and safe tumor resection, accurate and fast diagnosis of malignancy can be achieved by using the current system.
Der Kompass Digitalisierung
Authors: Kopp Ralf , Wienzek Tobias 
Published: February 2023

ZusammenfassungDieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) stellt den Kompass Digitalisierung als soziotechnische Gestaltungshilfe für Führungskräfte im Kontext von Digitalisierungsvorhaben vor. Obwohl soziotechnische Forschung in den letzten Jahren im Zuge der Auseinandersetzung um Industrie 4.0 und KI eine kleine Renaissance erfahren hat, wurden bisher kaum soziotechnisch fundierte Führungskonzepte und hiermit verknüpfte Gestaltungshilfen entwickelt.Unter der Prämisse, dass Führung im Kern eine Form der Interaktionsarbeit darstellt, werden Konturen eines solchen Konzeptes umrissen und mit der Skizzierung des Kompass Digitalisierung ein anschlussfähiges Instrument präsentiert, welches es Führungskräften bei Technikeinführungen ermöglicht Gestaltungsoptionen und ihre Konsequenzen für Arbeit frühzeitig in partizipativer Form erkenn- und bearbeitbar zu machen.
Soziotechnisches Assistenzsystem zur lernförderlichen Arbeitsgestaltung in der robotergestützten Montage
Authors: Albu-Schäffer Alin , Huchler Norbert , Kessler Ingmar , Lay Florian , Perzylo Alexander , Seidler Michael , Steinmetz Franz , Weitschat Roman 
Published: February 2023

ZusammenfassungDieser Beitrag der Zeitschrift Gruppe. Interaktion. Organisation. (GIO) widmet sich der lernförderlichen Gestaltung eines roboterbasierten Assistenzsystems für industrielle Montagetätigkeiten. Individualisierte Produkte, kleinere Losgrößen und beschleunigte Prozesse sind Aspekte des digitalen Wandels in der industriellen Fertigung und Teil des Leitbilds einer flexiblen Produktion. Mensch-Roboter-Kollaboration und wissensbasiertes Engineering sind aktuelle Ansätze, um diesen Anforderungen gerecht zu werden. Dieser Artikel stellt an einem Anwendungsbeispiel (Verdrahtung von Schaltschränken) einen ersten Ansatz vor, wie mittels wissensbasierter Technologien (v. a. Ontologien und deren logische Interpretation) Vorschläge zur Arbeitszuteilung zwischen Menschen und Robotern sowohl nach ökonomischen als auch nach Kriterien der humanen Arbeitsgestaltung automatisiert erstellt werden können. Zum einen können für jede Aufgabe ihre Anforderungen mit den individuellen Fähigkeiten und Stärken der Beschäftigten sowie mit denen des kollaborativen Robotersystems in einem Mixed-Skill-Konzept nach betrieblichen Kennziffern (z. B. Zeit, Qualität) abgeglichen werden, um sich so einem optimalen Produktionsablauf anzunähern. Zum anderen können dabei Aspekte einer humanen Gestaltung der Mensch-Maschine-Interaktion (MMI) berücksichtigt werden, die vordringlich mit Blick auf Lernförderlichkeit zusammengeführt werden. Lernförderlichkeit in der MMI setzt Zeit, Handlungsräume und förderliche Inhalte voraus und ist zugleich eine zunehmende Notwendigkeit, um vorausschauend auf den dynamisierten Wandel von Arbeit zu reagieren. Denn gerade mit dem Technikeinsatz ist ein starker Tätigkeitswandel in Richtung Entscheidungsträger und Problemlöser verbunden, der neben Qualifizierung und Weiterbildung auch niedrigschwelliger, arbeitsintegrierter Lerngelegenheiten bedarf. Gerade die kollaborative Robotik als Schlüsseltechnologie der flexiblen Fertigung macht es nötig, neue Konzepte für die Organisation des hybriden Zusammenwirkens von Mensch und Roboter zu entwickeln. Im Folgenden wird aufbauend auf den grundlegenden Ansatz das Konzept eines technischen Demonstrators vorgestellt, welches entlang eines empirischen Fallbeispiels entwickelt wurde. Die prototypische, technische Umsetzung basiert auf einer Arbeitsumgebung mit einem Roboterarm und zugehörigen Werkzeugen, formalen semantischen Beschreibungen der Fähigkeiten und Tätigkeiten von Menschen und Robotern sowie einer intuitiven Benutzeroberfläche, unter anderem für die individuelle Anpassung der generierten Arbeitszuteilungen.
Negative effects of time autonomy in digital collaboration
Authors: Mander Rebekka , Antoni Conny H. 
Published: February 2023

AbstractThis article in the journal Group. Interaction. Organization (GIO) focuses on the effects of time autonomy on job-to-home spillover and emotional exhaustion when employees face high time pressure in digital collaboration. We assume time autonomy to strengthen rather than to buffer the detrimental indirect effects of high time pressure on emotional exhaustion via job-to-home spillover, and that high digital collaboration amplifies this effect even further. In a sample of N = 111 employees, we investigated this research question using conditional process analysis. Results support our assumptions as for high digital collaboration high time autonomy amplified the detrimental indirect effect of time pressure on emotional exhaustion via job-to-home spillover, whereas for low digital collaboration high time autonomy buffered this indirect effect. Thus, employees’ risk for emotional exhaustion is higher when time pressure, time autonomy and digital collaboration are high. Therefore, employees and leaders should carefully consider their choices concerning the use of time in the context of digital collaboration.