bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN TEKNIK MENYUSUI DENGAN KELANCARAN PRODUKSI ASI PADA IBU MENYUSUI DI DERMAWATI MEDAN
Authors: Suwardi Suyanti , Marsaulina Ivansri , Harahap Novy Ramini , Yuliana Yuliana 
Published: July 2023

Breastmilk is the only baby's best food for up to six months because it has a nutritional composition for baby's growth and development. According to WHO in 2016 there were 40% of infants aged 0-6 months given exclusive breastfeeding. The aim of this research is to know the relationship of breastfeeding techniques with the smothness of breastmilk production on nursing mothers at Dermawati Medan. The type of this research is analytical survey research method with cross sectional approach. This research was conducted at Dermawati Clinic from July to September 2022. The populations in the study were breastfeeding mothers as many as 43 people. The samples of the study were 32 people with accidental sampling techniques. The data analysis used univariate and bivariate analysis and tested by using chi square test (sig-α 0,05). Based on the chi-square statistical test results obtained p-value value of 0.002 <sig α (0.05), means that there was a significant relationship between breastfeeding techniques and smoothness of Breasmilk production. The conclusion of this study shows that there is a relationship between breastfeeding techniques and the smoothness of breastmilk on nursing mothers at Deremawati Clinic Medan. It is suggested that the results of this study are expected to add insight and knowledge of mothers who are breastfeeding about the relationship of breastfeeding techniques with the smoothness of breastmilk production.

Abstrak
ASI merupakan satu-satunya makanan terbaik bayi sampai enam bulan karena mempunyai komposisi gizi untuk pertumbuhan dan perkembangan bayi. Menurut WHO tahun 2016, terdapat 40% bayi berusia 0-6 bulan diberikan ASI eksklusif. Tujuan penelitian ini Untuk Mengetahui Hubungan Teknik Menyusui dengan Kelancaran produksi ASI pada Ibu Menyusui di Klinik Dermawati Medan. Jenis penelitian yang digunakan adalah metode penelitian survei analitik dengan pendekatan cross sectional. Penelitian ini dilakukan di Klinik Dermawati, dari bulan Juli sampai September 2022. Populasi dalam penelitian adalah ibu yang menyusui yaitu 43 orang, sampel penelitian berjumlah 32 orang dengan teknik sampling accidental. Analisa data yang digunakan adalah analisa univariat dan bivariat dengan menggunakan uji chi square (sig-α 0,05). Berdasarkan hasil uji statistik chi-square diperoleh hasil nilai p-value sebesar 0,002 < sig α (0,05), artinya ada hubungan yang signifikan antara teknik menyusui dengan kelancaran produki ASI. Kesimpulan dalam penelitian ini ada hubungan Teknik Menyusui Dengan Kelancaran produksi Pada Ibu Menyusui di Klinik Dermawati Medan. Disarankan hasil penelitian ini diharapkan dapat menambah wawasan dan ilmu pengetahuan ibu yang menyusui tentang hubungan teknik menyusui dengan kelancaran produksi ASI.
Concomitant Use of Proton Pump Inhibitors and Palbociclib Among Patients With Breast Cancer
Authors: Lee Ju-Eun , Kwon Sun-Hong , Kwon Swan , Jung Hye-In , Nam Jin Hyun , Lee Eui-Kyung 
Published: July 2023

ImportanceProton pump inhibitors (PPIs) are commonly used drugs to relieve gastrointestinal tract symptoms, but their acid-inhibitory action negatively affects the bioavailability and clinical outcomes of orally administered concomitant drugs.ObjectiveTo identify the clinical outcomes of patients with advanced breast cancer who concomitantly use PPIs and palbociclib.Design, Setting, and ParticipantsThis retrospective cohort study used nationwide claims data between November 1, 2016, and July 31, 2021, in South Korea. Patients with breast cancer receiving palbociclib between November 1, 2017, and July 31, 2020, were identified. Patients whose prescriptions for palbociclib and PPI overlapped by at least 33% were classified into a concomitant PPI group. Patients who never received PPI during the palbociclib treatment period were classified into a nonconcomitant PPI group. Patients were selected through 1:3 propensity score matching for analyses.ExposuresConcomitant use of PPIs with palbociclib.Main Outcomes and MeasuresTime to progression and death. These outcomes were presented as progression-free survival (PFS) and overall survival (OS) and were analyzed using the Kaplan-Meier method and log-rank test. Cox proportional hazards regression was used to estimate the hazard ratio (HR) of concomitant PPI use associated with clinical PFS and/or OS.ResultsA total of 344 women were included in the concomitant PPI group and 966 in the nonconcomitant PPI group. Among 1310 patients identified after matching, 1108 (84.6%) were older than 50 years; 1111 (84.8%) were treated with letrozole and anastrozole (endocrine sensitive); and 199 (15.2%) were treated with fulvestrant (endocrine resistant). The median clinical PFS in the concomitant PPI group was shorter than that of the nonconcomitant PPI group (25.3 [95% CI, 19.6-33.0] vs 39.8 [95% CI, 34.9 to not applicable] months; P &amp;lt; .001), and the HR was 1.76 (95% CI, 1.46-2.13). Concomitant use of PPI was also associated with shorter OS (HR, 2.71 [95% CI, 2.07-3.53]). Both clinical PFS and OS in the concomitant PPI group were consistently poor in patients receiving endocrine-sensitive and endocrine-resistant treatment.Conclusions and RelevanceThese findings suggest that concomitant use of PPIs with palbociclib may hinder the complete therapeutic benefits of palbociclib in patients with breast cancer.
Superhydrophobic Surfaces to Combat Bacterial Surface Colonization
Authors: Ashok Deepu , Cheeseman Samuel , Wang Yi , Funnell Bronte , Leung Siu‐Fung , Tricoli Antonio , Nisbet David 
Published: July 2023

AbstractThe recent COVID‐19 pandemic and the accelerating rise of deaths associated with antibiotic‐resistant bacterial strains have highlighted the global health and economic threats caused by the super spreading of pathogens. A major route of transmission for pathogens is via surfaces contaminated by touch or droplets generated via sneezing and coughing. Current surface disinfection strategies are having diminishing efficacy, due to the increasing number of superbugs and the short‐lasting effect of disinfectants resulting in recontamination. New strategies for inhibiting surface‐mediated pathogen transmission are the focus of significant multi‐disciplinary efforts. Among those, the development of superhydrophobic surfaces (SHS) is increasingly regarded as a powerful alternative, or additive, to antimicrobial strategies. SHS provide a neutral/inert interface that can prevent viral and bacterial surface colonization. Here, the use of such water‐repellent coatings are critically reviewed to impede the surface‐mediated transmission of pathogens, addressing the challenges and future directions for their translation into real‐world settings.
Hetero‐Interface Manipulation in MoOx@Ru to Evoke Industrial Hydrogen Production Performance with Current Density of 4000 mA cm−2
Authors: Zhang Yu , Ma Chaoqun , Zhu Xiaojuan , Qu Kaiyu , Shi Peidong , Song Leyang , Wang Jing , Lu Qipeng , Wang An‐Liang 
Published: July 2023

AbstractConstructing and manipulating hetero‐interfaces for the electrocatalytic hydrogen evolution reaction (HER) is highly desirable, but still poses a significant challenge. Herein, this work adopts a facile way to controllably synthesize three different hetero‐interfaces by anchoring ultrafine Ru nanoparticles on various MoOx nanotube (NT) substrates, including MoO2, MoO2/MoO3, and MoO3. Remarkably, MoO2@Ru NT displays excellent HER activity with tiny overpotentials of 89 and 131 mV delivering large current densities of 500 and 1000 mA cm−2, respectively, far surpassing two other hetero‐interfaces, commercial Ru/C, Pt/C catalysts. Impressively, this hetero‐interface even achieves an exceptionally large current density of 4000 mA cm−2 at an overpotential of 322 mV. Moreover, MoO2@Ru NT presents exceptional stability for at least 100 h at 1000 mA cm−2 with negligible degradation. Both experimental observations and theoretical calculations suggest that moderate electron transfer from Ru to MoO2 enhances the water dissociation kinetics, and optimizes the hydrogen adsorption/desorption, thus simultaneously speeding up the HER kinetics. Furthermore, an anion exchange membrane electrolyzer assembled by obtained MoO2@Ru NT as a cathode electrocatalyst, shows attractive activity and excellent durability, with a low voltage of 1.78 V at 1000 mA cm−2, and a prolonged time period for 200 h at 1000 mA cm−2.
Associated anomalies in Pierre Robin sequence
Authors: Stoll Claude , Alembick Y. , Roth M. P. 
Published: July 2023

AbstractPierre Robin sequence (PRS) is frequently co‐occurring with other non‐PRS congenital anomalies. The types and the prevalence of anomalies co‐occurring with PRS vary in the reported studies. The aims of this report was to study the types and the prevalence of the anomalies co‐occurring with PRS in a well‐studied population northeastern France. The types and the prevalence of anomalies co‐occurring in cases with PRS were ascertained in all terminations of pregnancy, stillbirths and live births in 387,067 births occurring consecutively during the period 1979–2007 in the area covered by our registry of congenital anomalies which is population‐based, 89 cases of PRS were registered during the study period with a prevalence of 2.29 per 10,000 births, 69.7% of the cases had associated non‐PRS anomalies. Chromosomal abnormalities were present in 10 (11.2%) cases including three 22 q11.2 deletion. Non‐chromosomal recognizable conditions were diagnosed in 27 cases (30.3%) including 10 Stickler syndrome, 8 Treacher Collins syndrome, 3 cases with short stature and 6 other syndromes. Multiple congenital anomalies (MCA) were present in 25 cases (28.1%). The most frequent MCA were in the ear, face and neck (35 out of 98 anomalies, 35.7%), cardiovascular (18 anomalies, 18.4%), musculoskeletal (11 anomalies, 11.2%), central nervous (7 anomalies, 7.1%), urinary (6 anomalies, 6.1%), and eye (6 anomalies, 6.1%) system. The high prevalence of associated anomalies justifies a thorough screening for other congenital anomalies in cases with PRS.
Communicating shared situational awareness in times of chaos: Social media and theCOVID‐19 pandemic
Authors: Shahbazi Maryam , Bunker Deborah , Sorrell Tania C. 
Published: July 2023

AbstractTo effectively manage a crisis, most decisions made by governments, organizations, communities, and individuals are based on “shared situational awareness” (SSA) derived from multiple information sources. Developing SSA depends on the alignment of mental models, which “represent our shared version of truth and reality on which we can act.” Social media has facilitated public sensemaking during a crisis; however, it has also encouraged mental model dissonance, resulting in the digital destruction of mental models and undermining adequate SSA. The study is concerned with the challenges of creating SSA during the COVID‐19 pandemic in Australia. This paper documents a netnography of Australian public health agencies' Facebook communication, exploring the initial impact of COVID‐19 on SSA creation. Chaos theory is used as a theoretical lens to examine information perception, meaning, and assumptions relating to SSA from pre to post‐pandemic periods. Our study highlights how the initial COVID‐19 “butterfly effect” swamped the public health communication channel, leaving little space for other important health issues. This research contributes to information systems, information science, and communications by illustrating how the emergence of a crisis impacts social media communication, the creation of SSA, and what this means for social media adoption for crisis communication purposes.
DNAmetabarcoding illuminates the contribution of small and very small prey taxa to the diet of lions
Authors: Groen Kevin , Beekenkamp Sophie , de Iongh Hans H. , Lesilau Francis , Chege Mumbi , Narisha Luka , Veldhuis Michiel , Bertola Laura D. , van Bodegom Peter M. , Trimbos Krijn B. 
Published: July 2023

AbstractKnowledge of food web interactions is essential for understanding the role of carnivores in an ecosystem and designing appropriate conservation and management strategies to preserve them. These interactions can only be understood by studying carnivores' diets and obtaining comprehensive and unbiased diet data. For large carnivores—which typically rely on large herbivores as prey—the role of smaller prey species has not received attention. This study aims to quantify the contribution of small (5–50 kg) and very small (<5 kg) prey taxa in the diet of lions (Panthera leo melanochaita) in four Kenyan National Parks (NPs). We use DNA metabarcoding to achieve higher‐resolution insights into prey composition, which is less biased toward large prey species compared to traditional methods, such as carcass counts. Our study identified 24 prey taxa in a total of 171 lion fecal samples. Small and very small prey taxa together contributed 18.7% out of 278 prey occurrences in all fecal samples, with comparable small prey presence (ranging from 8% to 15%) in the diet for each NP studied. This approach proved to be useful in detecting small and very small prey species in the diet of lions and can therefore be used in future research to uncover the diverse diet composition of these large carnivores. The consistent presence of smaller prey species in the diet indicates that lions generally supplement their large prey diet with smaller prey.
Revisiting the fragmentation mechanism of catechin isomers
Authors: Syue Pai‐Chi , Li Kuok‐Fai , Ku Kuo‐Lung 
Published: July 2023

AbstractIntroductionThe reason for the neutral loss of 44 Da in catechin tandem mass spectrometry analysis is not yet clear. Past studies used low‐resolution mass spectrometers, which made isobaric ions easily misjudged or ignored. One of the important fragment ions [(epi)Catechin‐H+‐44]− is usually determined to be derived from the loss of C2H4O (MW = 44.0262) at the C‐ring of catechin anion. However, in the results of high‐resolution mass spectrometry, this ion is m/z = 245.0808, which does not meet the expected theoretical value (m/z = 245.0454). Because this ion should be the parent ion losing CO2 (MW = 43.9898), not C2H4O. Therefore, it is necessary to re‐deduce the structure and generation path of fragment ions.MethodIn this study, high‐resolution mass spectrometry was used to analyze and compare the mass fragmentation differences of phenol, phloroglucinol, and three dihydroxybenzene isomers to establish the source of CO2‐neutral loss of catechins.ResultIt was found that both phloroglucinol and resorcinol, which have the same structure as the A‐ring of catechin, can generate [M‐H+‐CO2]− fragment ions, while phenol, hydroquinone, and catechol are not.ConclusionsIt is demonstrated that the part of catechin anion contributing to CO2 neutral loss is the A‐ring rather than the B‐ring.
Adipocyte hypertrophy in mesenchymal stem cells from infants of mothers with obesity
Authors: Keleher Madeline Rose , Shubhangi Shreya , Brown Asya , Duensing Allison M. , Lixandrão Manoel E. , Gavin Kathleen M. , Smith Harry A. , Kechris Katerina J. , Yang Ivana V. , Dabelea Dana , Boyle Kristen E. 
Published: July 2023

AbstractObjectiveFat content of adipocytes derived from infant umbilical cord mesenchymal stem cells (MSCs) predicts adiposity in children through 4 to 6 years of age. This study tested the hypothesis that MSCs from infants born to mothers with obesity (Ob‐MSCs) exhibit adipocyte hypertrophy and perturbations in genes regulating adipogenesis compared with MSCs from infants of mothers with normal weight (NW‐MSCs).MethodsAdipogenesis was induced in MSCs embedded in three‐dimensional hydrogel structures, and cell size and number were measured by three‐dimensional imaging. Proliferation and protein markers of proliferation and adipogenesis in undifferentiated and adipocyte differentiating cells were measured. RNA sequencing was performed to determine pathways linked to adipogenesis phenotype.ResultsIn undifferentiated MSCs, greater zinc finger protein (Zfp)423 protein content was observed in Ob‐ versus NW‐MSCs. Adipocytes from Ob‐MSCs were larger but fewer than adipocytes from NW‐MSCs. RNA sequencing analysis showed that Zfp423 protein correlated with mRNA expression of genes enriched for cell cycle, MSC lineage specification, inflammation, and metabolism pathways. MSC proliferation was not different before differentiation but declined faster in Ob‐MSCs upon adipogenic induction.ConclusionsOb‐MSCs have an intrinsic propensity for adipocyte hypertrophy and reduced hyperplasia during adipogenesis in vitro, perhaps linked to greater Zfp423 content and changes in cell cycle pathway gene expression.image
ModeIIIfracture of composite laminates with elastic couplings in edge ring crack torsion test
Authors: Gong Yu , Gao Yuting , Li Zhaobin , Lin Wenjuan , Zhang Jianyu , Zhao Libin , Hu Ning 
Published: July 2023

AbstractIn this work, the distribution of the strain energy release rate (SERR) at the crack front of carbon fiber‐reinforced polymer laminates with elastic coupling is analyzed using the edge ring crack torsion (ERCT) test configuration. The SERR at the delamination front is calculated by virtual crack closure technique (VCCT). Elastic coupling laminates, including bending‐extension (BE) and bending‐torsion (BT) ones with different stacking sequences are studied. The effect of two different loading boundary conditions on the SERR distribution of laminates is also investigated. The results demonstrate that the distribution of SERR is significantly affected by the elastic coupling and stacking sequence. In addition, elastic coupling introduces mode I and mode II components in the ERCT configuration. However, their contribution is negligible. In comparison to unidirectional laminates, better uniformity of SERR distribution can be obtained in the BE and BT laminates. Pure mode III fracture without non‐uniformity is achievable by designing the elastic coupling of laminates. The obtained results can provide guidance for the standardization of the ERCT configuration used for the measurement of mode III fracture toughness.
Empiric dosing strategies to predict lamotrigine concentrations during pregnancy
Authors: Barry Jessica M. , French Jacqueline A. , Pennell Page B. , Karanam Ashwin , Harden Cynthia L. , Birnbaum Angela K. 
Published: July 2023

AbstractIntroductionMaintaining seizure control with lamotrigine is complicated by altered pharmacokinetics and existence of subpopulations in whom clearance increases or remains constant during pregnancy.ObjectiveOur objective was to characterize the potential for particular dosing scenarios to lead to increased seizure risk or toxicity.MethodsLamotrigine pharmacokinetic parameters obtained from our previous study were applied to a one‐compartment model structure with subpopulations (75:25%) exhibiting different clearance changes. A single‐patient simulation was conducted with typical pharmacokinetic parameter values from each subpopulation. Population‐level simulations (N = 48,000) included six dosing scenarios and considered four preconception doses using the R package mrgsolve (Metrum Research Group). Thresholds for efficacy and toxicity were selected as drug concentration that are 65% lower than preconception concentrations and doubling of preconception concentrations, respectively.ResultsIndividual simulation results demonstrated that without dose increases, concentrations fell below 0.65 at 6–8 weeks in the high clearance change (HC) subpopulation, depending on preconception clearance. While no simulated dosing regimen allowed all women in both subpopulations to maintain preconception concentrations, some regimens provided a more balanced risk profile than others. Predicted concentrations suggested potential increased seizure risk for 7%–100% of women in the HC group depending on preconception dose and subpopulation. Additionally, in 63% of dosing scenarios for women with low clearance change (LC), there was an increased risk of toxicity (34%–100% of women).SignificanceA substantial percentage of simulated individuals had concentrations low enough to potentially increase seizure risk or high enough to create toxicity. Early clearance changes indicate possible subpopulation categorization if therapeutic drug monitoring is conducted in the first trimester. An arbitrary “one‐size‐fits‐all” philosophy may not work well for lamotrigine dosing adjustments during pregnancy and reinforces the need for therapeutic drug monitoring until a patient is determined to be in the LC or HC group.
Interfacial Engineering Enables Perovskite Heteroepitaxial Growth on Black Phosphorus for Flexible X‐ray Detectors
Authors: Huang Hao , Zheng Ying , Liu Chang , Zhang Zhenyu , Gao Ming , Wang Jiahong , Liu Yanliang , Chu Paul K. , Yu Xue‐Feng 
Published: July 2023

Abstract2D materials with atomic‐scale thickness and mechanical robustness are required for flexible devices. The superior optoelectronic properties and high‐Z atoms in metal halide perovskites render them desirable for X‐ray detection, but the intrinsic brittleness is an obstacle hampering the applications in flexible detectors. Herein, an interfacial engineering strategy is demonstrated for the epitaxial growth of methylammonium lead bromide (MAPbBr3) on black phosphorus (BP) for flexible X‐ray detectors. The mechanically robust, high‐quality heterostructure consisting of a Pb transition layer is synthesized for the two‐way bridging of BP and MAPbBr3. Excellent optoelectronic properties such as a high X‐ray sensitivity of 1,609 ± 122 µC Gy−1 cm−2 (80 times higher than that of the commercial amorphous Se), a fast response time of 40 ± 5 ms, as well as a low detection limit of 3 µGys−1 (about a fifteenth of the medical chest X‐ray dose rate) are achieved from the simple and planar direct X‐ray detector fabricated on an organic filter membrane. More importantly, these flat and simple devices are bendable and mechanically durable by exhibiting only 10% photocurrent degradation after 200 bending cycles. The novel heterostructure has great potential in large‐area, flexible, and sensitive X‐ray detection applications.
A Multifunctional Asymmetric Fabric for Sustained Electricity Generation from Multiple Sources and Simultaneous Solar Steam Generation
Authors: Sun Shuangjie , Li Hui , Zhang Miaomiao , Sun Binbin , Xie Yibing , Zhou Wei , Yang Peipei , Mi Hao‐Yang , Guo Zhanhu , Liu Chuntai , Shen Changyu 
Published: July 2023

AbstractHarvesting electrical energy from water and moisture has emerged as a novel ecofriendly energy conversion technology. Herein, a multifunctional asymmetric polyaniline/carbon nanotubes/poly(vinyl alcohol) (APCP) that can produce electric energy from both saline water and moisture and generate fresh water simultaneously is developed. The constructed APCP possesses a negatively charged porous structure that allows continuous generation of protons and ion diffusion through the material, and a hydrophilicity–hydrophobic interface which results in a constant potential difference and sustainable output. A single APCP can maintain stable output for over 130 h and preserve a high voltage of 0.61 V, current of 81 µA, and power density of 82.4 µW cm−3 with 0.15 cm3 unit size in the water‐induced electricity generation process. When harvesting moisture energy, the APCP creates dry‐wet asymmetries and triggers the spontaneous development of electrical double layer with a current density of 1.25 mA cm−3, sufficient to power small electronics. A device consisting of four APCP can generate stable electricity of 3.35 V and produce clean water with an evaporation rate of 2.06 kg m−2 h−1 simultaneously. This work provides insights into the fabrication of multifunctional fabrics for multisource energy harvesting and simultaneous solar steam generation.