bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomics reveals serum metabolic signatures in H‐type hypertension based on mass spectrometry multi‐platform
Authors: Gao Siqi , Zhao Jinhui , Liu Xiaowei , Liu Liyan , Chen Rui 
Published: July 2023

AbstractBackgroundH‐type hypertension (HHT) is a disease combined with hyperhomocysteinaemia and hypertension (HT). This study aims to find specific metabolic changes and reveal the pathophysiological mechanism of HHT, which provide the theoretical basis for the early prevention and treatment of HHT.MethodsSerum samples from three groups including 53 HHT patients, 36 HT patients and 46 healthy controls (HC) were collected. The targeted and untargeted metabolomics analyses were performed to determine the metabolic changes. Based on multivariate statistical analysis, the serum potential metabolites were screened and different metabolic pathways were explored.ResultsOur results demonstrated that there were 28 important potential metabolites for distinguishing HT from HHT patients. Metabolic pathway analysis showed that the different metabolic pathways between HHT and HC group were arginine biosynthesis, arginine and proline metabolism, and tyrosine metabolism. The changed metabolic pathway of HT and HC group included linoleic acid metabolism. The specific metabolic pathways of HT‐HHT comparison group had phenylalanine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis; glycine, serine and threonine metabolism.ConclusionsMetabolomics analysis by mass spectrometry multi‐platform revealed the differences of metabolic profiles between HHT and HT subjects. This work laid the groundwork for understanding the aetiology of HHT, and these findings may provide the useful information for explaining the HHT metabolic alterations and try to prevent HHT.
Psychological toxicity in classical hematology
Authors: Pfeffer Michael A. , Martens Kylee , Kartika Thomas , McMurry Hannah , Olson Sven , DeLoughery Thomas , Shatzel Joseph J. 
Published: July 2023

AbstractAlthough considered “benign,” mild blood count abnormalities, genetic factors imparting inconsequential thrombotic risk, and low‐risk premalignant blood disorders can have significant psychological and financial impact on our patients. Several studies have demonstrated that patients with noncancerous conditions have increased levels of anxiety with distress similar to those with malignancy. Additionally, referral to a classical hematologist can be a daunting process for many patients due to uncertainties surrounding the reason for referral or misconstrued beliefs in a cancer diagnosis ascribed to the pairing of oncology and hematology in medical practice. If not properly triaged, incidental laboratory abnormalities can trigger extensive and costly evaluation. These challenges are compounded by a lack of consensus guidance and generalizability of modern reference ranges that do not adequately account for common influencing factors. Although often benign, incidental hematologic findings can lead to emotional suffering and careful consideration of the potential psychological and financial duress imparted to an individual must be considered. In this article, we will review the current literature describing the psychological effect of some commonly known hematologic conditions, identify benign causes for variations in hematologic laboratory values, and provide recommendations to reduce psychological toxicity as it pertains to hematologic testing.
Applying a Mixture Rasch Model‐Based Approach to Standard Setting
Authors: Peabody Michael R. , Muckle Timothy J. , Meng Yu 
Published: July 2023

AbstractThe subjective aspect of standard‐setting is often criticized, yet data‐driven standard‐setting methods are rarely applied. Therefore, we applied a mixture Rasch model approach to setting performance standards across several testing programs of various sizes and compared the results to existing passing standards derived from traditional standard‐setting methods. We found that heterogeneity of the sample is clearly necessary for the mixture Rasch model approach to standard setting to be useful. While possibly not sufficient to determine passing standards on their own, there may be value in these data‐driven models for providing additional validity evidence to support decision‐making bodies entrusted with establishing cut scores. They may also provide a useful tool for evaluating existing cut scores and determining if they continue to be supported or if a new study is warranted.
Repurposing synthetic and natural derivatives induces apoptosis in an orthotopic glioma‐induced xenograft model by modulating WNT/β‐catenin signaling
Authors: Daisy Precilla Senthilathiban , Kuduvalli Shreyas S. , Biswas Indrani , Bhavani Krishnamurthy , Pillai Agieshkumar Balakrishna , Thomas Jisha Mary , Anitha Thirugnanasambandhar Sivasubramanian 
Published: July 2023

AbstractBackgroundGlioblastomas arise from multistep tumorigenesis of the glial cells. Despite the current state‐of‐art treatment, tumor recurrence is inevitable. Among the innovations blooming up against glioblastoma, drug repurposing could provide profound premises for treatment enhancement. While considering this strategy, the efficacy of the repurposed drugs as monotherapies were not up to par; hence, the focus has now shifted to investigate the multidrug combinations.AimTo investigate the efficacy of a quadruple‐combinatorial treatment comprising temozolomide along with chloroquine, naringenin, and phloroglucinol in an orthotopic glioma‐induced xenograft model.MethodsAntiproliferative effect of the drugs was assessed by immunostaining. The expression profiles of WNT/β‐catenin and apoptotic markers were evaluated by qRT‐PCR, immunoblotting, and ELISA. Patterns of mitochondrial depolarization was determined by flow cytometry. TUNEL assay was performed to affirm apoptosis induction. In vivo drug detection study was carried out by ESI‐Q‐TOF MS analysis.ResultsThe quadruple‐drug treatment had significantly hampered glioma proliferation and had induced apoptosis by modulating the WNT/β‐catenin signaling. Interestingly, the induction of apoptosis was associated with mitochondrial depolarization. The quadruple‐drug cocktail had breached the blood–brain barrier and was detected in the brain tissue and plasma samples.ConclusionThe quadruple‐drug combination served as a promising adjuvant therapy to combat glioblastoma lethality in vivo and can be probed for translation from bench to bedside.
“I prefer working with mares, like women, difficult in character but go the extra mile”: A study of multiple inequalities in equine (sports) business
Authors: Jammaers Eline , Huopalainen Astrid 
Published: July 2023

AbstractThe idea that a “single category”—focus in the study of workplace inequality leads to oversimplification and obscures its complex nature is now generally accepted. Yet few concerns have been raised with regard to the “single species”—focus of inequalities in the context of management and organization studies. In this paper, we shed light on the interplay of multiple inequalities in the multispecies, sex‐integrated setting of equine (sports) business in the Belgian context, and paying particular attention to show jumping activities. An Ackerian analysis reveals the persistence of gendered inequalities despite women's “theoretically” improved chances of identifying with the ideal rider construct, following changed breeding preferences and an organizational logic of “passion‐merit.” Popular imageries of horses paradoxically reveal the lack of agency awarded to animals and the instrumental nature of the human–horse bond. This study opens the debate on how nonhuman animals may be integrated into core feminist organizational concepts, looking at organizational logic through a multispecies lens. We initiate a claim to knowledge about overlapping and intersecting forms of inequality in a posthumanist spirit whilst reflexively acknowledging our human‐centered approach to data collection. Finally, we ponder upon the question of what ontological and methodological shifts would be required to convincingly speak of multispecies inequality regimes.
A Complex Brownfields Case Study—The Former Bannister Federal Complex, Kansas City, Missouri
Authors: Cohen Harvey A. , Breslin Kevin P. , Rafferty Michael T. 
Published: July 2023

AbstractIn November 2017, 225 acres (91 ha) of the former Bannister Federal Complex (BFC) in Kansas City, Missouri were transferred from the Federal Government to Bannister Transformation & Development, LLC (BTD), for demolition; environmental corrective measures; and preparation of the site for redevelopment. This presented a once‐in‐a‐lifetime opportunity to reconfigure groundwater remedies and address long‐standing soil contamination issues. The property included more than 40 previously‐identified Solid Waste Management Units, 3.9 million square feet (362,000 m2) of buildings, subsurface utilities dating back to the 1940s, and an active groundwater containment system. Demolition of buildings and installation of an interim groundwater containment system began almost immediately after property transfer. In 2018, BTD substantially modified its project schedule to incorporate the construction of the first new buildings while demolition and remedial activities were ongoing. By October 2020, construction of the first new warehouse commenced while excavation and capping of contaminated soils, installation of a groundwater containment treatment systems, and abandonment of legacy utilities were still underway. Completion of this work, within the originally planned timeframe, was made possible by factors including up‐front multi‐year funding, early and ongoing engagement of regulators, an extended 3‐year due diligence program and planning stage, and establishment of well‐defined environmental targets. Both the soil and groundwater remedies were also designed with the flexibility needed to accommodate unknown conditions, changing schedules, and revisions to the regrading and redevelopment plans. This case study highlights key technical and management factors that led to the successful completion of this complex brownfields remediation project.
Fecal microbiota transplantation for recurrent Clostridioides difficile infection in frail and very old patients
Authors: Montalto Massimo , Gallo Antonella , Agnitelli Maria Chiara , Pellegrino Simona , Lipari Alice , Pero Erika , Covino Marcello , Landi Francesco , Gasbarrini Antonio , Cammarota Giovanni , Ianiro Gianluca 
Published: July 2023

AbstractBackgroundOlder age is a well‐known risk factor for recurrent and severe Clostridioides difficile infection (CDI). Fecal microbiota transplantation (FMT) is widely recognized as an effective and safe therapeutic option for the treatment of recurrent CDI (rCDI). However, the efficacy and safety of FMT for rCDI in very old patients are uncertain. This study evaluated the efficacy and safety of FMT in a group of very old subjects with rCDI, and the reliability of overall comorbidity and frailty assessment for identifying patients at higher risk of worse clinical outcomes.MethodsThis is a retrospective single‐center study including patients ≥85 years undergoing FMT for rCDI between 2014 and 2022. Primary outcomes included efficacy of FMT, defined as cure of CDI at 8 week‐follow‐up, and safety evaluation. At baseline, comorbidity was measured with the Charlson Comorbidity Index (CCI). Frailty was measured with the Clinical Frailty Scale (CFS).ResultsOverall, 43 patients with a median age of 88 years underwent FMT by colonoscopy in the study period. The rate of first FMT success was 77%. Five of the 10 patients who failed the first FMT infusion were cured after repeat FMT, with an overall efficacy of 88%. In patients with successful treatment, the CFS was significantly lower compared to those who failed the FMT or underwent repeat FMT (p < 0.01 for both). Mild adverse events occurred in 11 patients (25%). One death, not related to FMT or rCDI, occurred within 7 days from the first procedure.ConclusionsFMT is effective and safe in very old patients. Frailty and high comorbidity do not limit use of FMT in these patients. Frailty assessment has potential to better identify patients at higher risk of worse outcomes or for repeat treatment with FMT.
Work strains and disabilities in French workers: A career‐long retrospective study
Authors: Barnay Thomas , Defebvre Éric 
Published: July 2023

AbstractThis study aims to estimate the causal impact of detrimental working conditions on the self‐reported disabilities in France. Using a retrospective lifelong panel, we implement a mixed econometric strategy that relies on difference‐in‐differences and matching methods to take into account for selection biases as well as unobserved heterogeneity. Deleterious effects from exposure on disability are found, depending on the nature and magnitude of the strains. These results provide insights into the debate on legal retirement age postponement and justify policies being enacted early in individuals' careers, but also schemes that are more focused on psychosocial risk factors.
Dietary sodium intake and its relation to sleep duration, sleep quality and nocturnal urination in working‐aged Korean adults
Authors: Jung Ju Young , Oh Chang‐Mo , Kim Eugene , Park Sung Keun 
Published: July 2023

AbstractBoth sodium intake and sleep have an important effect on cardiovascular health. However, few studies have looked at the association between sodium intake and sleep. Therefore, we analysed the association of sodium intake with sleep quality, sleep duration and nocturnal urination. The data for the present study were obtained from the Kangbuk Samsung Health Study. Study participants were 156 696 working‐aged Korean adults (average age 38.0 years ±8.0 in men and 36.0 years ±8.1 in women). They were categorised into five groups by quintile of sodium intake, measured by food frequency questionnaire. Poor sleep quality and short sleep duration were determined by Pittsburgh Sleep Quality Index >5, and sleep duration <7 h, respectively. Nocturnal urination was defined as awakening to urinate more than three times a week. Multivariable adjusted logistic regression analysis was used in calculating the odds ratio (OR) and 95% confidence interval (CI) for poor sleep quality, short sleep duration and nocturnal urination (adjusted OR [95% CI]) across five study groups. In all study participants, increased sodium intake was significantly associated with poor sleep quality (quintile 1: reference, quintile 2: 1.07 [1.04–1.11], quintile 3: 1.12 [1.08–1.16], quintile 4: 1.15 [1.11–1.19] and quintile 5: 1.13 [1.09–1.18]). This pattern of relationship was similarly observed in association of sodium intake with short sleep duration (p for trend <0.001) and nocturnal urination (p for trend <0.001). In gender subgroup analysis, increased sodium intake had a significant association with poor sleep quality and short sleep duration in men and with poor sleep quality and nocturnal urination in women. In conclusion, high sodium intake is associated with an increased likelihood of poor sleep quality, short sleep duration and nocturnal urination.
Headache as the presenting manifestation of Gorlin‐Goltz syndrome with diastematomyelia: A case report
Authors: Ghosh Ritwik , León‐Ruiz Moisés , Purkait Siktha , Roy Dipayan , Ghosh Tapas , Benito‐León Julián 
Published: July 2023

AbstractGorlin‐Goltz syndrome (GGS) is an autosomal dominant multisystemic disease with high penetrance. Headache heralding GGS has been previously reported but without discussing potential sources. We report a patient with headache and a novel association (diastematomyelia), which helped with the diagnosis. A 46‐year‐old woman presented with persistent holocranial headache. On examination, countless hyperpigmented basal cell nevi over the face, pits over the palmar/plantar surface, and palmar and plantar keratosis were observed. A magnetic resonance imaging (MRI) of the spinal cord revealed diastematomyelia. Diagnosis of GGS was finally made. Headache and diastematomyelia should be included in the clinical picture of GGS.
Tannerella forsythia scavenges Fusobacterium nucleatum secreted NOD2 stimulatory molecules to dampen oral epithelial cell inflammatory response
Authors: Settem Rajendra P. , Ruscitto Angela , Chinthamani Sreedevi , Honma Kiyonobu , Sharma Ashu 
Published: July 2023

AbstractThe oral organism Tannerella forsythia is auxotrophic for peptidoglycan amino sugar N‐acetylmuramic acid (MurNAc). It survives in the oral cavity by scavenging MurNAc‐ and MurNAc‐linked peptidoglycan fragments (muropeptides) secreted by co‐habiting bacteria such as Fusobacterium nucleatum with which it forms synergistic biofilms. Muropeptides, MurNAc‐l‐Ala‐d‐isoGln (MDP, muramyl dipeptide) and d‐γ‐glutamyl‐meso‐DAP (iE‐DAP dipeptide), are strong immunostimulatory molecules that activate nucleotide oligomerization domain (NOD)‐like innate immune receptors and induce the expression of inflammatory cytokines and antimicrobial peptides. In this study, we utilized an in vitro T. forsythia–F. nucleatum co‐culture model to determine if T. forsythia can selectively scavenge NOD ligands from the environment and impact NOD‐mediated inflammation. The results showed that NOD‐stimulatory molecules were secreted by F. nucleatum in the spent culture broth, which subsequently induced cytokine and antimicrobial peptide expression in oral epithelial cells. In the spent broth from T. forsythia–F. nucleatum co‐cultures, the NOD‐stimulatory activity was significantly reduced. These data indicated that F. nucleatum releases NOD2‐stimulatory muropeptides in the environment, and T. forsythia can effectively scavenge the muropeptides released by co‐habiting bacteria to dampen NOD‐mediated host responses. This proof‐of‐principle study demonstrated that peptidoglycan scavenging by T. forsythia can impact the innate immunity of oral epithelium by dampening NOD activation.
Art dealers as competitors and community builders: Understanding the overlapping social logics of the contemporary art world
Authors: Rojas Fabio , De La Torre David 
Published: July 2023

AbstractArt dealers are often described as gatekeepers who are focused on their own position as well as the status of their artists and collectors. We argue that this is an incomplete account of art dealing. The goal of this article is to explain how art dealing is a “toolkit” that does not exclusively focus on status building and social capital, but also includes behavior associated with accessing the visual arts field and community development. First, art dealers often have a background that has strong social ties to art, which provides them with intimate knowledge of the art world and social connections with artists, collectors, and other art world actors. For that reason, entry into art dealing reflects intimate knowledge of art practices, what we call “proximate connoisseurship.” Second, art dealerships reflect both competitive and communal factors. Art dealers may choose to work with artists based on their ability to generate income, social capital, and prestige (“competitive logic”), but art dealers may also employ a “communal logic” focused on friendships and creating community. This theory of art dealers is illustrated with excerpts from interviews with 34 dealers randomly selected from the rosters of international art fairs such as Art Basel Miami, EXPO Chicago, Aqua, and the New Art Dealers Alliance show.
“I'm Moderna, what are you?” Evidence that people favor those who received their same brand COVID‐19 vaccine
Authors: Meese William B. , Howell Jennifer L. 
Published: July 2023

AbstractIn two studies, we investigated the extent to which people are biased toward people with the same COVID‐19 vaccine brand using a monetary allocation task. Informed by theoretical approaches to intergroup bias and the minimal‐groups paradigm, we expected that, when deciding how to allocate financial resources among three different people—each with an equal need for assistance but a different COVID‐19 vaccine brand—people would allocate more money, on average, to those who received the same versus different vaccine brand than participants personally received. We found in Study 1 (N = 94) that people given a hypothetical $10.00 experimental endowment allocated an average of $2.00 more when a person was a member of their vaccine ingroup than to those from their vaccine brand outgroup. We replicated this effect in Study 2 (N = 219), finding that people continued to allocate more money ($1.42) to a person from their vaccine brand ingroup versus those from their vaccine brand outgroup. Taken together, this work suggests that, among vaccinated people, the brand of another person's vaccine meaningfully influences the allocation of monetary resources and that people are biased toward people with the same COVID‐19 vaccine brand. Implications for social identity theories are discussed.
Acquired perforating dermatosis: A clinicopathologic study, and the features of dermoscopy and reflective confocal microscopy of 37 cases
Authors: Gao Zhe , Lu Si‐Jia , Shan Shi‐Jun 
Published: July 2023

AbstractBackgroundAcquired perforating dermatosis (APD) is a rare skin condition characterized by degenerated materials eliminated from the dermis. Several retrospective studies on APD have been reported; however, few data are available on Chinese APD and their features on dermoscopy and reflective confocal microscope (RCM) assays.ObjectiveThe aim of this study was to retrospectively evaluate the clinical and histopathologic data of 37 acquired perforating dermatosis cases, and assess their features on dermoscopy and RCM.MethodsThirty‐seven APD patients were retrospectively enrolled in our study. We characterized the clinical histopathological features, concomitant diseases, treatment responses, and the dermoscopy and RCM findings.ResultsPruritus was the most common symptom, with the lower extremities as the most predilection sites (86.5%, n = 32; 91.9%, n = 34, respectively). Concomitant diseases were found in 34 patients (92.6%), among which diabetes mellitus was the most common, followed by thyroid nodules, allergic dermatosis, and chronic renal insufficiency. Dermoscopy and RCM assays were performed in 11 patients. The typical RCM images were hyperreflective cord‐like structures from the epidermis to dermis. Dermoscopy features of fully developed lesions showed central ulceration with peripheral hairpin‐like or loop‐like capillaries with characteristic garland arrangements.ConclusionAPD is an uncommon skin disorder associated with various systemic conditions in Chinese individuals. Thyroid disorders are an overlooked complication and may play an important role in the development of APD. The results of this study indicate that noninvasive dermoscopy and RCM examination are helpful in the rapid diagnosis and early intervention of APD.