bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second-order Optimality Conditions for Nonsmooth Multiobjective Fractional Optimization Problems
Authors: Wang Haijun , Kang Gege 
Published: January 2023

Abstract
The aim of this paper is to discuss the theoretical aspects of multiobjective fractional problems. We consider a class of multiobjective fractional optimization problems (FOP) with inequality and degenerate equality constraints in which the objective function and the inequality constraints are only locally Lipschitz. We give second-order necessary conditions for the existence of local weak Pareto minimum and strict local Pareto minimum of order two for (FOP). Then we establish Fritz-John type necessary conditions for local weak Pareto minimum to problem (FOP), meanwhile, by introducing two constraint qualifications, we prove that the Fritz-John type necessary conditions become the Kuhn-Tucker type. The applicability of our conclusions is illustrated with some examples.
WITHDRAWN: Optimization Technique For Optimal Location Selection Based On Medical Image Watermarking On Healthcare System
Authors: Umaamaheshvari A. , Sivasankari K. , Suguna N. , Kshirsagar Pravin R. , Tirth Vineet , Rajaram A. 
Published: January 2023

Abstract
The optimization algorithms mimic the process of natural evolution. In watermarking, appropriate positions to insert the watermark is identified by the image that covers. These positions represent the populations of genetic algorithms. The major drawback in genetic algorithm are that it may get stuck-up at a local optimum while moving towards the best global solution and hence the result is poor when compared to other local optimization techniques. The proposed work based on Bandelet based biogeography firefly hybrid algorithms. The Number of pixels, Intensity of the pixel and contrast are considered for watermarking. The redundancy is reduced by Bandelet and used to determine the best location to embed the information into an image both locally and globally. Results of these techniques are compared based on coefficient correlation, index structural similarity, and noise ratio from peak signal.
Neuroprotective role of DPP-4 inhibitor Linagliptin against neurodegeneration, neuronal insulin resistance and neuroinflammation induced by intracerebroventricular streptozotocin in rat model of Alzheimer’s disease
Authors: Siddiqui Nazia , Ali Javed , Parvez Suhel , Najmi Abul Kalam , Akhtar Mohd 
Published: January 2023

Abstract
Alzheimer’s disease (AD) is an age-related, multifactorial progressive neurodegenerative disorder manifested by cognitive impairment and neuronal death in the brain hippocampus, yet the precise neuropathology of AD is still unclear. Continuous failure of various clinical trial studies demands the utmost need to explore more therapeutic targets against AD. Type 2 Diabetes Mellitus and neuronal insulin resistance due to serine phosphorylation of Insulin Receptor Substrate-1 at 307 exhibits correlation with AD. Dipeptidyl Peptidase-4 inhibitors (DPP-4i) have also indicated therapeutic effects in AD by increasing the level of Glucagon-like peptide-1 in the brain after crossing Blood Brain Barrier. The present study is hypothesized to examine Linagliptin, a DPP-4i in intracerebroventricular streptozotocin induced neurodegeneration, and neuroinflammation and hippocampal insulin resistance in rat model of AD. Following infusion on 1st and 3rd day, animals were treated orally with Linagliptin (0.513mg/kg, 3mg/kg, and 5mg/kg) and donepezil (5 mg/kg) as a standard for 8 weeks. Neurobehavioral, biochemical and histopathological analysis was done at the end of treatment. Dose-dependently Linagliptin significantly reversed behavioral alterations done through locomotor activity (LA) and morris water maze (MWM) test. Moreover, Linagliptin augmented hippocampal GLP-1 and Akt-ser473 level and mitigated soluble Aβ (1–42), IRS-1 (s307), GSK-3β, TNF-α, IL-1β, IL-6, AchE and oxidative/nitrosative stress level. Histopathological analysis also exhibited neuroprotective and anti-amylodogenic effect in Hematoxylin & eosin and Congo red staining respectively. The findings of our study concludes remarkable dose-dependent therapeutic potential of Linagliptin against neuronal insulin resistance via IRS-1 and AD-related complication. Thus, demonstrates unique molecular mechanism that underlie AD.
Improved reliability of intraoperative language testing through pre-operative baseline linguistic scores and baseline object naming
Authors: Moritz Ina , Dreyer Felix R. , Ohlerth Ann-Kathrin , Koerber Mareike , Chenitir Chokri , Schneider Heike , Gebert Pimrapat , Vajkoczy Peter , Picht Thomas , Faust Katharina 
Published: January 2023

Abstract
Visual object naming (vON) is the most commonly applied linguistic test during awake surgeries with electrical stimulation mapping. Little is known about the predictive value of general preoperative linguistic and cognitive function for the intraoperative object naming ability of the patient. We aimed at analyzing these correlations, in order to potentially define cut-off values for when intraoperative vON tasks may no longer be gainful. Also, we aimed to assess the benefits of patient-specific tailoring of object-images. 46 patients with left-sided perisylvian tumors, scheduled for awake surgeries, underwent a preoperative workup including a comprehensive test battery for general linguistic function, a cognitive function test, and an object naming task, employing a set of objects that was validated prior in an inhouse study. For intraoperative use, the initial set of 80 objects was tailored down to a slack of objects, each patient could reproducibly name. Correlations between the respective tests were drawn using multivariate analyses. On average, patients were only able to correctly name 81% of the original validated baseline set of objects (range from 16%-88%). Aachen Aphasia Test (AAT) scores and DemTect test scores (DS) correlated tightly with the vON. Patients with initial AAT scores of < 80%, DS of < 50%, and baseline vON scores of < 50% were no longer able to reliably comply with the intraoperative task. Patient specific tailored sets of objects improve the reliability of intraoperative object naming tasks. An elaborate preoperative language evaluation will give an estimate of the expected object naming ability of the patient and will help put into perspective intraoperative performances. There may be cut-off values in a-priori language function that may disqualify for awake surgeries.
Traditional Chinese Patent Medicine Qizhijiangtang Capsule for Non- Proliferative Diabetic Retinopathy: Study Protocol for a Randomized Controlled Trial
Authors: Pang Bing , Guo He , Zhang Yue-ying , Feng Shuo , Hu Hua-jie , Sun Ye , Cao Ai-mei , Lu Chun-qian , Zhang Wei-hua , Ni Qing 
Published: January 2023

Abstract
Background: Diabetic retinopathy remains a leading cause of vision loss globally. Here, we investigated the efficacy and safety of Qizhijiangtang capsule (QZJC), a kind of traditional Chinese patent medicine, for patients with NPDR.
Methods: This study is a multi-center, randomized, controlled clinical trial. A total of 100 participants will be randomly assigned in a 1:1 ratio to QZJC group or QZJC placebo group. The treatment duration lasts 24 weeks. The primary outcome is the changes in the degree of retinal microaneurysm lesions assessed by fundus photography and fundus fluorescence angiography before and after treatment. The secondary outcomes include the changes in corrected visual acuity, blood glucose, glycosylated hemoglobin, urinary microalbumin excretion rate, the improvement of TCM syndromes and TCM symptoms.
Discussion: We postulate that NPDR patients will benefit from QZJC. If successful, this work will provide preliminary evidence that QZJC could delay the progress of DR.
Trial registration: Chinese Clinical Trial Registry no. ChiCTR1900023506. The protocol has registered at http://www.chictr.org.cn/showprojen.aspx?proj=39622. Registered 31 May 2019.
Template (preprint statement): This manuscript has been preprinted [https://doi.org/10.21203/rs.3.rs-596869/v1].
Effect of composite coating of konjac glucomannan with green tea polyphenols on antioxidant activity and shelf-life of post-harvest passion fruit
Authors: Feng Shaobiao , Pan Huahong , Li Gangfeng , Li Xiang , Luo Linjie , Yang Tao , Lv Zhenzhen 
Published: January 2023

Abstract
In this study, the effect of konjac glucomannan (KGM) and green tea polyphenols (GTP) on the preservation quality of passion fruit was explored by using different GTP (0.1%, 0.2%, and 0.3%) in combination with 0.5% KGM. Quality indexes, physicochemical parameters, and antioxidant enzyme activities of passion fruit were measured every three days during storage. Overall, the results revealed that the 0.2% GTP/0.5% KGM composite coating prevailed as the best preservation group, effectively delaying the increase of shrinkage index, weight loss rate, and respiratory intensity. Moreover, the GTP/KGM composite coating could inhibit the increase of polyphenol oxidase and peroxidase activities while retarding the aging and browning of passion fruit. In conclusion, these results suggested that the treatment of natural composite materials (GTP/KGM) has positive effects on extending post-harvest life and improving the quality of passion fruit.
Proximate chemical analysis and effect of age and height of Oxytenanthera abyssinica on fiber morphology and chemical compositions for pulp and paper production potential
Authors: Worku Limenew Abate , Bachheti Archana , Tadesse Mesfin Getachew , Bachheti Rakesh Kumar 
Published: January 2023

Abstract
This study examined the chemical composition, fiber morphology, and physical properties of Oxytenanthera abyssinica culm to assess its pulping potential. TAPPT and Franklin's methods have been used for experiments. The statistical analysis showed that the chemical composition of Oxytenanthera abyssinica is influenced by the age of the plant.The amount of cellulose in the culm increases with age, while ash and extractive content decrease with an increase in age. Thethree-year agedaverage chemical content of the plant was 49.26 ± 0.13, 21.31 ± 0.15, and 20.63 ± 0.12 cellulose, hemicellulose, and lignin contents respectively. There is a significant difference between one, two, and three-year-aged plants (P < 0.05) in cellulose, lignin, ash, and extractive content. The position of the culm also affectsthe fiber morphology of Oxytenanthera abyssinica. The fiber's length, diameter, cell wall thickness, and lumen diameter increase from top to bottom, whereas the flexibility and slenderness ratio decrease. The average fiber morphology of Oxytenanthera abyssinica was flexibility ratio (0.72 ± 0.10), Runkel ratio (0.35 ± 0.10), slenderness ratio (109.98 ± 0.21), lumen diameter (15.63 ± 0.03 µm), cell wall thickness (2.74 ± 0.03 µm), fiber length (2.40 ± 0.10 mm) and fiber diameter (21.83 ± 0.09 µm). The above data showed that the mean value of the fiber length of the plant is greater than 1.5mm, the Runkel ratio was less than 1, and the slenderness ratio was greater than 70 standard values. The result also showed that the average bulk density and the moisture content were 660 kg/m3 and 9.6%, respectively. Although Oxytenanthera abyssinica is widely grown in the study area, no comprehensivestudies have been carried out on fiber morphology, chemical composition, and physical properties based on age and height. Thus, this research was carried out to study the plant's fiber characteristics to assess its suitability for pulp and paper production.Based on the above data, the three-year aged bottom part of Oxytenanthera abyssinica is recommended for moreyield of pulp and high-quality paper production than the first and second-year aged plant.
Application Value of Mind Mapping and Self-Drawing in the Residency Standardized Training Examination During the COVID-19 pandemic
Authors: Lin zimei , Zhang Chao , Pan Hui-li , Xu Wen , Hong Yu-rong , Huang Pin-tong 
Published: January 2023

Abstract
Purpose To explore the effect of mind mapping and self-drawing on medical residents preparing for the standardized national residency training examination.
Methods Eighteen residents (third year) in an ultrasound program were enrolled in this study. All residents used traditional methods plus mind mapping and self-drawing to study for the examination. The effect of the learning methods on residents was evaluated and analyzed by test scores and surveys.
Results The mean pretest score was 74.33 ± 11.08, compared to a mean posttest score of 89.54 ± 4.21. For each body system— urology, obstetrics/gynecology, cardiology and alimentary system— posttest scores were significantly higher than pretest scores (P < 0.01). The difference was not significant for the superficial and general principles of the ultrasound system (P = 0.94, 0.13). However, overall, residents obtained significantly higher practical posttest scores than those on the pretest (P < 0.01), and the level of satisfaction among residents was high(94.4%).
Conclusions Mind mapping and self-drawing can be applied to the review process for standardized residency training examinations and can help medical residents improve review efficiency and retain medical knowledge.
Seismic Performance and SSI effects of a Two-Storey RC School Building during the 2014 Cephalonia, Greece, earthquake sequence
Authors: Giarlelis Christos , Repapis Constantinos , Lamprinou Evlalia , Mylonakis George , Manolis George , Sextos Anastasios 
Published: January 2023

Abstract
The response of a two-storey RC school building in the town of Argostoli, Cephalonia Island, Greece, during the seismic sequence of January and February 2014, is examined. The structure was built following an older generation of seismic codes dating from the 1950s, which provide limited strength and ductility against lateral loads. Despite the severity of ground shaking, the building suffered relatively minor damage, like most of the RC buildings in the town. Following a short presentation of some basic seismological, structural and geotechnical aspects of the seismic sequence, the paper focuses on the seismic performance of the structure at hand. To this end, a series of detailed non-linear static and time-history dynamic analyses are reported, which highlight the interplay of soil, foundation and superstructure in modifying the seismic demand. It is demonstrated that SSI had an unexpectedly important (detrimental) role in the behaviour of the structure, by increasing its natural period by about 11-13% and aggravating ductility demand in almost all columns, despite the stiff soil conditions (Vs = 440 m/s). The results shed light on the seismic performance of the building and help drawing conclusions on the engineering effects of the 2014 Cephalonia earthquake sequence.
Fabrication of graphitized carbon fibers from fusible lignin and their application in supercapacitors
Authors: Zhou Linfei , You Xiangyu , Wang Lingjie , Qi shijie , Wang Ruichen , Uraki Yasumitsu , Zhang Hui Jie 
Published: January 2023

Abstract
Lignin-based carbon fibers (LCFs) with graphitized structures decorated on their surfaces were successfully prepared using simultaneous catalyst loading and chemical stabilization of melt-spun lignin fibers, followed by quick carbonization functionalized as catalytic graphitization. This technique not only enables surficial graphitized LCF preparation at a relatively low temperature of 1200 °C but also avoids additional treatments used in conventional carbon fiber production. The LCFs were then used as electrode materials in a supercapacitor assembly. Electrochemical measurements confirmed that LCF-0.4, a sample with relatively low specific surface area of 89.9 m2 g−1, exhibited the best electrochemical properties. The supercapacitor with LCF-0.4 had a specific capacitance of 50.2 F g−1 at 0.5 A g−1, power density of 644.9 kW kg−1, energy density of 15.7 Wh kg−1, and capacitance retention of 100% after 1500 cycles even without activation.
Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta- analyses
Authors: Frigerio Gianfranco , Ferrari Chiara Matilde , Fustinoni Silvia 
Published: January 2023

Abstract
Background.
Per-/polyfluoroalkyl substances (PFASs) are persistent organic pollutants and suspected endocrine disrupters.
Objective.
The aim of this work was to conduct a systematic review with meta-analysis to summarise the associations between prenatal or childhood exposure to PFASs and childhood overweight/obesity.
Methods.
The search was performed on the bibliographic databases PubMed and Embase with text strings containing terms related to prenatal, childhood, overweight, obesity, and PFASs. Only papers describing a biomonitoring study in pregnant women or in children up to 18 years that assessed body mass index (BMI), waist circumference (WC), or fat mass in children were included. When the estimates of the association between a PFAS and an outcome were reported from at least 3 studies, a meta-analysis was conducted; moreover, to correctly compare the studies, we developed a method to convert the different effect estimates and made them comparable each other.
Results.
In total, 354 and 565 articles were retrieved from PubMed and Embase, respectively, resulting in a total of 613 articles after merging duplicates. The papers included in this systematic review were 31: 18 evaluating prenatal exposure to PFASs, 11 childhood exposure, and 2 both. Overall, results were conflicting, with positive, negative, and null associations. 17 papers were included in meta-analyses (12 prenatal, 3 children, and 2 both). The method implemented for data conversion allowed a suitable comparison of different effect estimates. Meta-analyses evaluating the associations between prenatal exposure to PFOA, PFOS, PFNA, PFHxS, and the outcomes BMI, WC, and Dual-Energy X-ray Absorptiometry (DXA) showed no significant results. Meta-analyses for the associations between childhood exposure to PFASs and the outcomes BMI showed no significant results except for a negative association between PFNA and BMI (pooled estimate from a random effect model: -0.045; 95%CI: -0.087, -0.002), however, more studies are required to confirm the strength of this association.
Conclusion.
To increase the reliability of meta-analyses in environmental epidemiology we suggest the conversion of effect estimates to compare different studies. The pooled evidence of the meta-analyses of the present study suggests that there is no overall association between exposure to PFASs and childhood overweight/obesity.
Predictors of Renal Damage in non diabetic Metabolic Dysfunction associated Fatty Liver Disease (MAFLD) Patients: Role of Tumor Necrosis Factor α
Authors: Younis Mustafa Adel Ahmed , Zaghloul Amr M , Hashim Marwa S. , Ali Tasneem Mohammed , Mohammed Ali Hussein , Ahmed Nesma M. 
Published: January 2023

Abstract
Background:
The risk of chronic kidney disease (CKD) has shown increasing incidence among patients with metabolic dysfunction associated fatty liver disease (MAFLD). The kidney is affected in inflammatory conditions and TNFα has been involved in different inflammatory cascade leading to renal damage. Less is known about the relation between MAFLD and the risk of CKD in Egyptian non diabetic patients. Our study explores the role of TNFα as a predictor of renal damage in those patients.
Method:
We evaluated 237 non diabetic patients with MAFLD using transient elastography (TE) with CAP.
CKD was defined by an albumin-to creatinine ratio (A/Cr) >30 mg/g if persistent for more than 3 months. Patients were subgrouped into two groups: group (A) included patients with CKD and group (B) included patients without CKD. Human TNF levels in serum were assessed utilizing an enzyme-linked immunosorbent assay (ELISA) . In addition, logistic regression and stepwise multiple logistic regression were used for the evaluation of the factors associated with renal damage. The ROC analysis was used to assess the role of TNF in predicting renal damage and the best cut off point.
Results: The prevalence of CKD among the studied group was (61.6 %.). Patients with CKD had higher values of waist circumference and BMI. They also have a significantly higher liver stiffness measurements (LSM) and CAP values. The ROC curves showed that the TNF α could predict the presence of chronic kidney disease with cut off value (23.05 ng/L) with a sensitivity of 98% and a speciﬁcity of 72%.
Conclusion:
In patients MAFLD and with other metabolic risk factors for CKD, TNF α could predict the presence of chronic kidney disease.
However, we need more studies with a higher number of patients to confirm our results.
Anisotropy and Asymmetry of the Elasticity of Lattice Materials
Authors: Yin Huiming 
Published: January 2023

Abstract
Lattice materials formed by hinged springs or elastic bonds may exhibit diverse anisotropy and asymmetry features of the overall elastic behavior depending on their unit cell configuration. The recently developed singum model transfers the force-displacement relationship of the springs in the lattice to the stress-strain relationship in the continuum particle, and provides the analytical form of tangential elasticity. When a pre-stress exists in the lattice, the stiffness tensor significantly changes due to the effect of the configurational stress. Different lattice structures lead to different symmetry of the stiffness tensors, which is demonstrated by five lattices. When all bonds exhibit the same length, regular hexagonal, honeycomb, and auxetic lattices demonstrate that the stiffness changes from an isotropic to anisotropic, from symmetric to asymmetric tensor. When the central symmetry of the unit cell is not satisfied, the primitive cell will contain more than one singums and the Cauchy-Born rule fails by the loss of equilibrium of the single singum. A secondary stress is induced to balance the singums, which may lead to the loss of minor symmetry of the stiffness tensor. Displacement gradient dij=uj,i is proposed to replace strain in the constitutive law for the general case because u1,2 and u2,1 may produce different stress states. Although the honeycomb lattice still exhibits isotropic behavior, for general auxetic lattices, an anisotropic and asymmetric elasticity is obtained with the loss of both minor and major symmetry, which is also demonstrated in a square lattice with unbalanced central symmetry and a chiral lattice. The modeling procedure and results may be generalized to three dimension and other lattices with the anisotropic and asymmetric stiffness.