bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous coronary intervention with ridaforolimus-eluting stents in long lesions: the BIONICS 38 mm prospective trial
Authors: Jonas Michael , Ben-Yehuda Ori , Banai Shmuel , Segev Amit , Danenberg Haim , Assali Abid , Tuvali Ortal , Haberman Dan , Chernin Gil 
Published: July 2023

Background
The ridaforolimus-eluting stent (RES) system is a novel cobalt alloy-based coronary stent with a durable elastomeric polymer eluting ridaforolimus. The aim of this trial was to assess the performance of a 38 mm RES in long coronary lesions.

Methods
A prospective, multicenter, single-arm, open-label clinical trial. Clinical follow-up was performed at 30 days, 6 months, and 1 year after the procedure. Target lesions were located in native coronary arteries or bypass graft conduits, with visually estimated diameters of ≥2.75 mm to ≤4.25 mm. The primary endpoint was combined efficacy (final in-stent residual diameter stenosis <30%) without 30-day major adverse cardiovascular events (MACE) (composite of cardiac death, any myocardial infarction), or ischemia-driven target lesion revascularization.

Results
A total of 50 patients were enrolled in the study. Fourteen (28%) had acute coronary syndromes; 17 (34%) had diabetes. The mean lesion length was 32.4 mm ± 8.3, reference vessel diameter 2.88 mm ± 0.45, minimal lumen diameter 0.80 mm ± 0.41, and percent diameter stenosis 72.6% ± 13.2. The primary endpoint was achieved in 88% (44/50) of the patients (95% confidence interval: 75.7–95.5%). Thirty-day and 1-year MACE rates were 6% and 8%, respectively. Target lesion failure after 1 year occurred in three patients (6%). Forty-seven lesions (94%) were treated successfully, with final in-stent diameter stenosis of < 30% [95% confidence interval: (84–99%).

Conclusion
Percutaneous coronary intervention (PCI) of long lesions with a 38 mm RES achieved satisfactory results, and support the safety and efficacy of PCI with RES in patients with long lesions. (ClinicalTrials.gov NCT03702608).
Financial toxicity in thyroid cancer survivors
Authors: Bogdanovski Anastasia K. , Sturgeon Cord , James Benjamin C. 
Published: July 2023

Purpose of review
Financial burden and distress are high in patients with thyroid cancer. However, little has been done to evaluate potential interventions to mitigate financial toxicity in survivors. This review will cover current data on the impact of financial toxicity on quality of life and clinical outcomes in patients with thyroid cancer and highlight areas for future study.

Recent findings
Thyroid cancer incidence has nearly tripled in the past decades, and cost of treatment is predicted to rise more than other cancers over the next decade. With mean age of diagnosis at 51 years, most patients begin treatment while still working, do not qualify for Medicare or Social Security, and are susceptible to higher financial burden. Though thyroid cancer has high survival rates, some studies suggest patients have worse quality of life and higher financial burden than more morbid cancers.

Summary
Thyroid cancer survivors have high rates of financial toxicity, and there remains need for longitudinal studies to evaluate how financial burden may change during the treatment process while also assessing potential tools to mitigate this burden.
Recent Advances in Blood-Based Liquid Biopsy Approaches in Prostate Cancer
Authors: Cani Andi K. , Salami Simpa S. 
Published: July 2023

Abstract
The advent of high-throughput technologies has enabled the analysis of minute amounts of tumor-derived material purified from body fluids, termed “liquid biopsies.” Prostate cancer (PCa) management, like in many other cancer types, has benefited from liquid biopsies at several stages of the disease. Although initially describing circulating tumor cells in blood, the term “liquid biopsy” has come to more prominently include cell-free, circulating tumor DNA, as well as RNA, proteins, and other molecules. They provide tumor molecular information representing the entire, often-heterogeneous disease, relatively noninvasively and longitudinally. Blood has been the main liquid biopsy specimen in PCa, and urine has also proven beneficial. Technological advances have allowed clinical implementation of some liquid biopsies in PCa, in disease monitoring and precision oncology. This narrative review introduces the main types of blood-based PCa liquid biopsies focusing on advances in the past 5 years. Clinical adoption of liquid biopsies to detect and monitor the evolving PCa tumor biology promises to deepen our understanding of the disease and improve patient outcomes.
Refining Auxiliary Orthotopic Liver Transplantation (AOLT) Improves Outcomes in Adult Patients with Acute Liver Failure
Authors: Pravisani Riccardo , Cocchi Lorenzo , Cesaretti Manuela , Dondero Federica , Sepulveda Ailton , Farges Olivier , Weiss Emmanuel , Vilgrain Valérie , Francoz Claire , Roux Olivier , Belghiti Jacques , Durand Francois , Lesurtel Mickaël , Dokmak Safi 
Published: July 2023

Objective:
To investigate whether and how experience accumulation and technical refinements simultaneously implemented in auxiliary orthotopic liver transplantation (AOLT) may impact on outcomes.

Background:
AOLT for acute liver failure(ALF) provides the unique chance of complete immunosuppression withdrawal after adequate native liver remnant regeneration, but is a technically demanding procedure. Our department is a reference center for ALF and an early adopter of AOLT.

Methods:
This is a single center retrospective before/after study of a prospectively-maintained cohort of 48 patients with ALF who underwent AOLT between 1993 and 2019. In 2012 technical refinements were implemented to improve outcomes: (i)favoring the volume of the graft rather than that of the native liver, (ii)direct anastomosis of graft hepatic artery with recipient right hepatic artery instead of the use of large size vessels, (iii)end-to-side hepatico-choledocostomy instead of bilio-enteric anastomosis. Early experience(1993-2011) group(n=26) and recent experience(2012-2019) group(n=22) were compared. Primary endpoint was 90-day severe morbidity rate (Clavien-Dindo≥IIIa) and secondary endpoints were overall patient survival and complete immunosuppression withdrawal rates.

Results:
Compared with the earlier experience group, the recent experience group was associated witha lower severe complication rate (27% vs. 65%,P<0.001), as well as less biliary (18% vs. 54%,P=0.017) and arterial (0% vs. 15%,P=0.115) complications. The 1-, 3- and 5-year patient survival was significantly improved(91%, 91%, 91% vs. 76%, 61%, 60%,P=0.045). The rate of complete immunosuppression withdrawal increased to 94% (vs. 70%,P=0.091) with no need of long-term graft explant.

Conclusions:
These technical refinements favoringthe liver graftand reducing morbidity may promote AOLT implementation among LT centers.
Quick changeover design: a new Lean methodology to support the design of machines in terms of rapid changeover capability
Authors: Braglia Marcello , Di Paco Francesco , Frosolini Marco , Marrazzini Leonardo 
Published: July 2023

PurposeThis paper presents Quick Changeover Design (QCD), which is a structured methodological approach for Original Equipment Manufacturers to drive and support the design of machines in terms of rapid changeover capability.Design/methodology/approachTo improve the performance in terms of set up time, QCD addresses machine design from a single-minute digit exchange of die (SMED). Although conceived to aid the design of completely new machines, QCD can be adapted to support for simple design upgrades on pre-existing machines. The QCD is structured in three consecutive steps, each supported by specific tools and analysis forms to facilitate and better structure the designers' activities.FindingsQCD helps equipment manufacturers to understand the current and future needs of the manufacturers' customers to: (1) anticipate the requirements for new and different set-up process; (2) prioritize the possible technical solutions; (3) build machines and equipment that are easy and fast to set-up under variable contexts. When applied to a production system consisting of machines subject to frequent or time-consuming set-up processes, QCD enhances both responsiveness to external market demands and internal control of factory operations.Originality/valueThe QCD approach is a support system for the development of completely new machines and is also particularly effective in upgrading existing ones. QCD's practical application is demonstrated using a case study concerning a vertical spindle machine.
Experimental investigation on residual capacity of square steel-reinforced concrete-filled steel tubular columns after fire
Authors: Sun Jinhua 
Published: July 2023

PurposeSteel-reinforced concrete-filled steel tubular (SRCFST) columns have been increasingly popular in engineering practice for the columns' excellent seismic and fire performance. Significant design progress guidance has been made through continuous numerical and experimental research in recent years. This paper tested and analysed the residual loading capacity of SRCFST columns under axial loading after experiencing non-uniform ISO-834 standard fire.Design/methodology/approachThe experimental research covered the main parameter of heating conditions, 1-side and 2-side fire, through two specimens. Two specimens were heated and loaded simultaneously in the furnace for 240 min. After cooling, the columns were moved to the hydraulic loading system and loaded to failure to determine the columns' residual capacity.FindingsThe experimental results indicated that the non-uniform heating area plays an essential role in the overall performance of SRCFST columns, the increasing heating area of columns results in lower residual loading capacity and stiffness. The SRCFST columns still had a high loading capacity after heating and loading in the fire.Originality/valueThe comparison of experimental data against design results showed that the design method generated a 16% safety margin for S2H4 and a 39% safety margin for S1H4.
One foot in academia and one in work-life – the case of Swedish industrial PhD students
Authors: Bernhard Irene , Olsson Anna Karin 
Published: July 2023

Purpose
The purpose of this study is to explore the benefits and barriers for learning in industrial PhD education through the perspectives of industrial PhD students. A work-integrated learning (WIL) approach is applied to highlight key issues that university and industry need to consider promoting mutual learning.

Design/methodology/approach
The empirical context is a Swedish university profiling WIL offering PhD programs in three disciplines for industrial PhD students from both the private and public sectors. Data was gathered using qualitative methods; 19 semistructured interviews with industrial PhD students.

Findings
Findings show that industrial PhD students are developing practical and transferable skills, hence, contributing to research of interest for academia and work–life. Identified benefits for learning include proximity and access to data, project and networks and contextual understanding and tacit knowledge. Barriers for learning are the perceived limited understanding of employers, the dilemma of balancing and switching between different roles, lack of belonging and identity, deficient collaboration agreements and ethical dilemmas.

Research limitations/implications
Contributes insights into an industrial PhD education transforming along with societal needs promoting a future workforce of researchers with skills, new work practices and learning capabilities applicable in the work–life of contemporary society.

Originality/value
This study contributes to the emerging field of studies of alternative doctoral educations by identifying benefits and barriers for learning and providing recommendations for how university and industry may promote learning in a resilient industrial PhD education collaboration.
Ketamine for postoperative pain treatment in spinal surgery: Systematic review with meta‐analysis and trial sequential analysis
Authors: Tornøe Anders Schou , Pind Alison Holten , Laursen Christina Cleveland Westerdahl , Andersen Cheme , Maagaard Mathias , Mathiesen Ole 
Published: July 2023

AbstractAimWe aimed to assess the beneficial and harmful effects of perioperative pain treatment with ketamine in patients undergoing spinal surgery.MethodsWe searched Medline, Embase, and CENTRAL from inception until 15 February 2023 for randomised clinical trials comparing ketamine with placebo or no intervention in patients undergoing spinal surgery. The primary outcomes were cumulative opioid consumption at 24 h postoperatively and serious adverse events. We adhered to recommendations of the Cochrane Collaboration and performed meta‐analysis, Trial Sequential Analysis (TSA) to assess the risks of random errors, risk of bias assessment to evaluate the risks of systematic errors, and used the Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsWe included a total of 28 randomised clinical trials enrolling 2110 participants providing data for our pre‐defined outcomes. Twenty‐three trials enrolled adult participants and 5 trials enrolled paediatric participants. Three trials were at low risk of bias. Meta‐analysis and TSA of trials including adults showed that ketamine versus placebo or no intervention seemed to reduce the cumulative 24‐h opioid consumption (mean difference −17.57 mg; TSA‐adjusted 95% confidence interval, −24.22 to −10.92; p < .01; low certainty of evidence), and there was no evidence of a difference of ketamine versus placebo or no intervention on the risk of serious adverse events (risk ratio 2.16; 96.7% confidence interval, 0.35 to 13.17; p = .36; very low certainty of evidence).ConclusionIn adults undergoing spinal surgery, ketamine may reduce cumulative 24‐h opioid consumption. Ketamine may increase the occurrence of serious adverse events, but the evidence was very uncertain.
Intraoperative ultrasonography (IOUS)‐guided vs conventional laparoscopic nephrectomy: a randomised control trial
Authors: Das Manoj K. , Rohith Gorrepati , Mandal Swarnendu , Gaur Abhay Singh , Nayak Prasant , Kumaraswamy Santosh , Tarigopula Vivek , Dheroo Dheeraj Kumar , Tripathy Sambit 
Published: July 2023

ObjectivesTo assess the efficacy of routine use of intraoperative ultrasonography (IOUS) in improving perioperative outcomes in patients undergoing IOUS‐guided laparoscopic nephrectomy (IOUS‐LN) and conventional laparoscopic nephrectomy (C‐LN).Patients and MethodsThis was a parallel‐arm, single‐blinded, randomised controlled trial (CTRI/2021/12/038906). All patients undergoing LN, either for benign or malignant causes, were included. Patients undergoing partial/cytoreductive nephrectomy, with venous thrombus were excluded. In the study arm, IOUS‐guided renal vascular assessment was performed after colon mobilisation and a standard LN was performed in the control arm. The primary outcome was intraoperative duration. The secondary outcomes were blood loss, need for open conversion, blood transfusion, perioperative complications, duration of Intensive Care Unit (ICU) stay and length of hospitalisation (LOH). The patients were followed for 3 months after surgery.ResultsA total of 104 patients were included, with 52 in each arm. Demographic characteristics were comparable in both arms. A significant reduction in the operative duration (mean [sd] 181.69 [40.8] vs 199.7 [41.8] min, P = 0.02) was seen in the IOUS‐LN group. The difference in blood loss showed no significant difference when compared between both groups (median [interquartile range] 84.55 [74–105.5] vs 99.95 [78.5–111] mL, P = 0.08). On subgroup analysis, the reduction in the operative duration was significant in patients who underwent laparoscopic simple nephrectomy (LSN; mean [sd] 194.4 [42.5] vs 221.2 [36.4] min, P = 0.01), whereas comparable operative durations were seen in patients undergoing laparoscopic radical nephrectomy (LRN; mean [sd] 168.96 [35.3] vs 178.3 [35.9] min, P = 0.34). Similar conversion rates were seen in both groups (P = 0.98) along with blood transfusions (P = 0.78). The LOH, ICU stay, and complications were similar in both groups. Significantly less blood loss (P = 0.03) was noted with IOUS in patients undergoing LSN. IOUS did not influence any outcomes in patients undergoing LRN.ConclusionIntraoperative ultrasonography significantly reduced the operative duration in LN, but with no significant reduction in the volume of blood loss. Significant reduction in intraoperative duration and blood loss was seen in patients who underwent LSN on subgroup analysis.
Biomarkers of immune checkpoint inhibitor response and toxicity: Challenges and opportunities
Authors: Goodman Rachel S. , Jung Seungyeon , Balko Justin M. , Johnson Douglas B. 
Published: July 2023

SummaryImmune checkpoint inhibitors have transformed cancer therapy, but their optimal use is still constrained by lack of response and toxicity. Biomarkers of response may facilitate drug development by allowing appropriate therapy selection and focusing clinical trial enrollment. However, aside from PD‐L1 staining in a subset of tumors and rarely mismatch repair deficiency, no biomarkers are routinely used in the clinic. In addition, severe toxicities may cause severe morbidity, therapy discontinuation, and even death. Here, we review the state of the field with a focus on our research in therapeutic biomarkers and toxicities from immune checkpoint inhibitors.
Whole‐of‐government and joined‐up government: A systematic literature review
Authors: Aoki Naomi , Tay Melvin , Rawat Stuti 
Published: July 2023

AbstractWe conducted a systematic literature review of 340 journal articles (1992–2021) pertaining to whole‐of‐government (WG) and joined‐up government (JUG)—two terms that denote public sector efforts to promote cross‐boundary work and restructuring. This review clarifies and renews our understanding of developments with respect to WG/JUG research. While JUG articles do not appear to be increasing, the number of WG articles is on a general upward trend. As of 2021, more WG articles were published on countries other than the Western nations typically recognized as centers for these reforms, signaling increasing global relevance of the topic. These articles were published in over 200 journals and span various policy spheres, suggesting the wide impact research can have. While the qualitative studies we reviewed update the list of recommendations for effective WG/JUG, large‐N hypothesis testing remains limited—a gap that can be addressed to generate robust knowledge on this topic.
MdHB7‐like positively modulates apple salt tolerance by promoting autophagic activity and Na+ efflux
Authors: Yang Jie , Qiu Lina , Mei Quanlin , Sun Yunxia , Li Na , Gong Xiaoqing , Ma Fengwang , Mao Ke 
Published: July 2023

SUMMARYSalt stress adversely affects the yield and quality of crops and limits their geographical distribution. Studying the functions and regulatory mechanisms of key genes in the salt stress response is important for breeding crops with enhanced stress resistance. Autophagy plays an important role in modulating the tolerance of plants to various types of abiotic stressors. However, the mechanisms underlying salt‐induced autophagy are largely unknown. Cation/Ca2+ exchanger proteins enhance apple salt tolerance by inhibiting Na+ accumulation but the mechanism underlying the response to salt stress remains unclear. Here, we show that the autophagy‐related gene MdATG18a modulated apple salt tolerance. Under salt stress, the autophagic activity, proline content, and antioxidant enzyme activities were higher and Na+ accumulation was lower in MdATG18a‐overexpressing transgenic plants than in control plants. The use of an autophagy inhibitor during the salt treatment demonstrated that the regulatory function of MdATG18a depended on autophagy. The yeast‐one‐hybrid assay revealed that the homeodomain‐leucine zipper (HD‐Zip) transcription factor MdHB7‐like directly bound to the MdATG18a promoter. Transcriptional regulation and genetic analyses showed that MdHB7‐like enhanced salt‐induced autophagic activity by promoting MdATG18a expression. The analysis of Na+ efflux rate in transgenic yeast indicated that MdCCX1 expression significantly promoted Na+ efflux. Promoter binding, transcriptional regulation, and genetic analyses showed that MdHB7‐like promoted Na+ efflux and apple salt tolerance by directly promoting MdCCX1 expression, which was independent of the autophagy pathway. Overall, our findings provide insight into the mechanism underlying MdHB7‐like‐mediated salt tolerance in apple through the MdHB7‐like‐MdATG18a and MdHB7‐like‐MdCCX1 modules. These results will aid future studies on the mechanisms underlying stress‐induced autophagy and the regulation of stress tolerance in plants.
What influences decisions to donate plasma? A rapid review of the literature
Authors: Berger Mary , Easterbrook Adam , Holloway Kelly , Devine Dana , Bansback Nick 
Published: July 2023

AbstractBackground and ObjectivesPlasma has become an essential ingredient for various medical treatments. Many blood collection agencies rely on voluntary non‐remunerated donation when collecting plasma, but at present many do not collect sufficient plasma to meet domestic demands. This rapid review sought to explore the factors that have been found to influence people's decisions to donate plasma to inform future research.MethodsSearches were conducted in PubMed, PsycINFO, Social Sciences Citation Index and CINAHL for peer‐reviewed journal articles that discussed plasma donation and the factors associated with donor behaviour. Pertinent information from included articles was extracted and arranged in themes.ResultsIn total, 33 articles were included in this review. Three main themes were identified by the authors. The first focused on site‐level factors related to blood collection agencies' engagement with plasma donors and their influence on plasma donation experiences. The second theme considered how individual characteristics and experiences influence willingness to donate plasma. The third theme examined social and cultural‐level factors, such as how social networks and community shape perceptions and experiences with donation.ConclusionOur findings suggest that the current understanding of plasma donation is focused mainly on converting whole blood donors and also centres on individual‐level factors to donation. Further research must examine what factors attract non‐whole blood donors to become plasma donors, focusing on broader social‐level influences. This review will inform policies and interventions for blood collection agencies to increase plasma donors.
Draft genome sequence of
Pseudomonas
sp. GOM6, a lipolytic strain isolated from seawater of the Gulf of Mexico
Authors: Rojas-Vargas Jorge , Muriel-Millán Luis Felipe , Pardo-López Liliana 
Published: July 2023

ABSTRACT

We report here the draft genome sequence of a marine
Pseudomonas
sp. novel species with lipase activity isolated from a deep-sea water sample of the Gulf of Mexico. The genome consists of 4.3 Mbp in 48 contigs.