bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple accessory fimbriae on fallopian tubes with unilateral fallopian diverticulum
Authors: Qiang Xiaoteng , Li Yin 
Published: May 2023

Abstract
This paper reports a rare case of subtle distal tubal pathology (SDTP) (diverticulum combined with a single accessory fimbria on the left fallopian tube + two accessory fimbriae on the right fallopian tube). Laparoscopic surgery can correct the pathological changes in the fimbrial end of the fallopian tubes and improve fertility potential.
Vitamin D Levels in the Small Newborn for Gestational Age. How Much do Maternal Levels Influence?
Authors: Pierdant-Pérez Mauricio , Ramos-Jimenez Alicia Yasmin , Villegas-Álvarez Carolina , Bravo-Ramirez Ana María , Roman-Flores Adolfo San , Flores-García José Andrés 
Published: May 2023

Abstract
Introduction: Relationship between maternal vitamin D (VitD) levels and newborn (NB) small for gestational age (SGA) is uncertain, maternal deficit may imply low levels at birth and affect evolution of NB.
Objective: Determine if maternal VitD levels influence its (SGA) levels, and relationship with maternal body mass index (BMI).
Material and methods: Cohort study, multiple regression model, Wilcoxon SR and Spearman's rho used to compare the VitD levels.
Results: 63 mothers, 25.88 (±5.1) years, BMI 31.2 (±4) Kg/m2, median VitD 14.8 [9.05] ng/ml, VitD levels: 35 (55.5%) deficient, 13 (21%) insufficient and 15 (24%) sufficient. 68 NB 35.78 (±2.58) GW, weight 1871.98 (±449) g, 7 (10.3%) percentile <5 and 61 (89.7%) percentile 5- 10, VitD 10.1 [6.72] ng/dl, VitD levels: 6 (8.8%) severely deficient, 45 (66.2%) deficient, 10 (14.7%) insufficient and 7 (10.3%) sufficient; significantly different.
Conclusions: VitD levels in overweight mothers significantly influence vitamin levels in SGA NB.
Terfenol-D’s induction magnetic field in the case of electromagnetic drive GMA
Authors: Wang Qingdong , Wei Jianfeng 
Published: May 2023

Abstract
Under the role of applied magnetic field, different values and directions of magnetic induction intensity will be produced in different sections of the magnetostrictive material (Terfenol-D) in GMA (giant magnetostrictive actuator). When mono-coil is used to measure the magnetic induction intensity of the magnetostrictive material, measures must be taken to reduce the influence of the coil on the magnetic induction intensity. The method proposed in this paper can accurately measure the magnetic induction intensity of magnetostrictive material, it uses multi-coils to create the most suitable near-zero magnetic field at the detecting points, so as to reduce the influence of the coils on the magnetostrictive material itself and realize the accurate measurement of magnetostrictive material’s magnetic induction intensity.
The Impact of Treosulfan -based Conditioning for Inborn Errors of Immunity: Is Dose Monitoring Crucial?
Authors: Ersoy Gizem Zengin , Cipe Funda , Fisgin Tunç , Aksoy Basak Adaklı , Oner Ozlem Basoglu , Hashemi Nazli , Aydogdu Selime , Erdem Melek , Dikme Gurcan , Murat Koza , Bozkurt Ceyhun 
Published: May 2023

Abstract
In children with inborn errors of immunity (IEI) who receive a hematopoietic stem cell transplant (HSCT), treosulfan-based conditioning is currently preferred. This study aimed to investigate early and late outcomes and examine the effect of treosulfan dose monitoring on outcomes. Seventy-three pediatric patients receiving this management between 2015 and 2022 were included. Overall survival rate was 80%, and event-free survival was 67.8%. A larger treosulfan dose AUC increased the rate of early toxicity (p=0.034) and slowed lymphocyte engraftment (r=0.290; p=0.030). Underlying disease, treosulfan AUC, donor type, stem cell type, number of immunosuppressive agents, the dose of anti-thymocyte globulin, and post-transplantation cyclophosphamide did not increase acute graft-versus-host disease. The risk of mixed chimerism (MC) in patients with autoimmune lymphoproliferative syndrome and leukocyte adhesion deficiency was higher than those with severe combined immunodeficiency (p=0.021 and p=0.014, respectively). The risk of MC was lower in those receiving peripheral blood stem cells (SC) compared with bone marrow-derived SC (OR=0.204, p=0.022). The AUC of treosulfan dose was not associated with poorer late outcomes. Treosulfan is an agent that can be used safely in the IEI patient group; level measurement appears essential to identify early toxicities. Prospective studies with more extended follow-up periods are needed.
Assessing the Malaria burden and Community Response to the Malaria Control and Management Programs in Omoro District, Northern Uganda
Authors: Divas Soyekwo , Opiyo Elizabeth A , Austin Reginald , Ochaya Stephen 
Published: May 2023

Abstract
Background The government of Uganda have implemented several malaria controls programs like Indoor Residual Spraying, use of Insecticide Treated Nets, tests and treat strategy, IPT for pregnant women, introduction of Village Health Teams to manage fevers and radio and TV education programs on malaria prevention and control. However, malaria is still the leading cause of hospitalization and death in our health systems. This study explored the malaria burden and community response to government malaria control programs in Omoro district.Method This retrospective and perspective study involved 576 patient results from Health facilities data from HCIIIs of Odek, Bobi, Lapainat, Lalogi HCIV and 288 study participants from Lutori and Lagude cells, Atyang A and Lagwaya villages who consented to answer the pre-tested questionnaire. The health facilities were purposively selected for malaria confirmed cases with microscopy and mRDTs, while households were simple randomly selected.Results The prevalence of malaria in Omoro district in 2018 and 2019 was at 69.46% and 93%, respectively. And the average number of malaria attacks an individual gets in district obtained from the health facility 3 and community data was 3. Among the local remedies used was Bidens pilosa from leave extracts. The use of oloevera, carica papaya, mango roots and bark, lemon grass leaves, bitter leaf, aloevera, cotton leaves were used for treatment and prevention of malaria. The obtained chi-square value P = 0.001, 0.000, 0.000, 0.001 denotes that there was significant association of malaria attacks between household size, household head, age, and occupation, respectively.Conclusion The average combined health facility and community number of malaria attacks an individual gets in Omoro district is 3 times a year with malaria prevalence of 69.46% and 93% in 2018 and 2019, respectively. The number of people who use local herbal herbs for malaria treatment and management were few, though these had less number of malaria attacks. Response to government malaria control programs was limited by high poverty level in the community.
The clinical significance of plasma sCD25 as valuable biomarker for progression and prognosis of tuberculosis
Authors: Yu Xin , Niu Yayan , Xu Junchi , Zhang Xiaolong , Wu Haiyan , Wang Yuhan , Zhang Jianping , Wu Meiying 
Published: May 2023

Abstract
Background sCD25 is an important immune molecule for T cell regulation. Tracking the detection of plasma sCD25 plays an important role in the evaluation of immune function, progression, and prognosis of tuberculosis (TB) patients. This study analyzed the association of plasma sCD25 levels with clinical, laboratory, CT imaging characteristics, and clinical outcome of TB patients.Methods The clinical data of 303 TB patients treated in the Fifth People's Hospital of Suzhou from October 2019 to January 2022 were retrospectively analyzed. The levels of sCD25 in plasma were detected by ELISA. According to the cut-off threshold of plasma sCD25 levels, the patients were divided into below (Group TB1) and above (Group TB2) groups. The correlation of plasma sCD25 levels with clinical, laboratory, and CT imaging characteristics of TB patients, as well as their TB treatment outcome were analyzed.Results The levels of plasma sCD25 of patients with TB patients were higher than that of the healthy control group (P < 0.01). Among the 303 TB patients, the levels were increased in Group TB2 patients (0.602 ± 0.216 vs. 1.717 ± 0.604 ng/ml, P < 0.001), and there was a progressive reduction after anti-TB treatment. Furthermore, patients in Group TB2 showed higher positive rates in sputum smear (52.0% vs. 34.3%; P = 0.003), sputum culture (69.7% vs. 56.9%; P = 0.032), Xpert MTB/RIF (66.3% vs. 51.2%; P = 0.013) and TB-DNA (51.5% vs. 31.2%; P = 0.001) than those in Group TB1. Patients in Group TB2 had higher incidence in cough (78.8% vs. 62.3%; P = 0.004), expectoration (64.4% vs. 45.1%; P = 0.001), concomitant extrapulmonary TB (14.1% vs. 5.9%; P = 0.016), cavities (47.9% vs. 34.0%; P = 0.022), and unfavorable outcomes after anti-TB treatment.Conclusion sCD25 plays an important role in the prognosis and clinical outcome of TB. Tracking plasma sCD25 detection of TB patients has evident clinical significance. It is noteworthy that when the plasma sCD25 levels are significantly elevated, patients should be cautious of the progression and unfavorable outcomes of TB.
Association between non-dipping blood pressure pattern and different glucometabolic profile during oral glucose tolerance test
Authors: Condoleo Valentino , Maio Raffaele , Cassano Velia , Bonfrate Leonilde , Pelaia Corrado , Armentaro Giuseppe , Miceli Sofia , Fiorentino Teresa Vanessa , Perticone Maria , Succurro Elena , Andreozzi Francesco , Sesti Giorgio , Sciacqua Angela 
Published: May 2023

Abstract
It’s known that, a not physiological blood pressure (BP) circadian pattern has been associated with increased risk of organ damage and cardiovascular (CV) event. The aim of this study was to assess the association between circadian BP pattern and glucometabolic phenotypes occurring after oral glucose tolerance test (OGTT). We recruited 810 hypertensive Caucasian patients. All participants underwent to OGTT, laboratory test and 24-hours ambulatory BP monitoring (ABPM). The analysis of collected data allowed classifying patients based on nocturnal BP profiles into four categories: dippers, non-dippers, extreme dippers, and inverse dippers. Considering the dipping pattern, the proportion of non-dippers in normal glucose tolerance patients with 1-hour glucose ≥ 155 mg/dL (NGT ≥ 155) (36.4%) was higher than NGT < 155 (29.6%) and impaired glucose tolerance (IGT) (34.8%), but lower than type 2 diabetes group (T2DM) (52.6%) (p = 0.001). The proportion of dippers was lower in NGT ≥ 155 (47%) and T2DM (34.6%), when compared with NGT < 155 (53.8%) and IGT (51.2%) (p = 0.017). From logistic regression analysis, 1-hour glucose ≥ 155 increased the risk of a pathological nocturnal drop in BP by 74%, (OR = 1.740, 95% CI = 1.254–2.415, p < 0.0001). In addition, the improvement in 1 unit of Matsuda was responsible for a 3.5% risk decrease (OR = 0.965, 95% CI = 0.958–0.971, p < 0.0001) while e-GFR determined a 0.9% risk reduction of nocturnal BP drop (OR = 0.991, 95% CI = 0.984–0.999, p = 0.020). Our data demonstrated the existence, in newly diagnosed hypertensive patients, of an association between circadian BP profile and altered glycemic response during OGTT, in particular NGT ≥ 155 subjects are associated with a non-dipper BP pattern, this is clinically relevant because may explain, at least in part, the increased CV risk in this setting of patients.
WITHDRAWN: Resveratrol inhibits ferroptosis and decelerates heart failure progression via Sirt1/p53 pathway activation
Authors: Wei Zhang , Shaohuan Qian , Bi Tang , Heng Zhang , Chao Shi 
Published: May 2023

Abstract
Resveratrol is an organic compound widely studied for its therapeutic uses. We investigated whether resveratrol exerts cardioprotective effects by inhibiting ferroptosis via the Sirt1/p53 pathway. A heart failure model was established by aortic coarctation in Sirt1knockout mice. The superoxide dismutase (SOD), glutathione (GSH) levels, and mitochondrial morphology in murine heart tissues were assessed at different time points to determine the role of ferroptosis in heart failure progression. The cardiac function of mice with heart failure was evaluated by determining the brain natriuretic peptide (BNP) and sST2 concentration. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were transfected with the p53 K382R mutant and Sirt1 interference lentiviral vectors. Immunoprecipitation (IP) experiments were performed to investigate whether Sirt1 influences ferroptosis via p53 K382 acetylation and SLC7A11 expression modulation. Resveratrol improved cardiac function in mice and decelerated ferroptosis and fibrosis progression in heart failure. However, the ability of resveratrol to prevent ferroptosis and treat heart failure was lost after silencing Sirt1. Sirt1 reduced ferroptosis by diminishing the levels of p53 K382 acetylation, reducing the degradation of SLC7A11, and increasing the levels of GSH and glutathione peroxidase 4 (GPX4) in cells. In conclusion, by activating the Sirt1/p53 pathway in heart failure, resveratrol decreased the depletion of SLC7A11, inhibited ferroptosis, and improved cardiac function.
A novel T cell function positive regulators-related signature for the immunotherapeutic efficacy prediction to colorectal cancer
Authors: Pu Ke , Gao Jingyuan , Xu Chuan 
Published: May 2023

Abstract
T-cell function positive regulators (TFPRs) as T-cell proliferation and activation factors seem to be a prognostic value for colorectal cancer (CRC). However, the roles of the tumor microenvironment (TME) and immunotherapeutic response are still unknown. We analyzed their expression patterns based on the prognostic top-ranked TFPRs using the four independent transcriptome datasets. According to the differential expression genes (DEGs) of two subtypes, the TFPR risk scoring model was constructed using the LASSO and Cox regression. Then, we analyzed the association of the TFPR risk model with the survival time, clinical information, TME, tumor mutation, microsatellite instability (MSI), Cell stem cells (CSC) index, chemotherapy, targeted therapy, and immunotherapy. The TFPR risk model had a significant predictive association with CRC and predicted the immune cell content, HLA, immune checkpoint blade expression levels, mutation burden, CSC index characteristic, and immunotherapeutic efficacy. These findings may improve our understanding of TFPRs in CRC development and provide a new assessment system for CRC immunotherapy.
Bi-axially Loaded RC Beam-Column Joints and Haunch Retrofit
Authors: Marchisella Angelo , Muciaccia Giovanni 
Published: May 2023

Abstract
The issue of reinforced concrete (RC) beam--column joints in existing frames, built without regards on seismic provisions, is considerably actual. In fact, beam--column failure has been often mentioned as one of the causes of buildings' collapses post--surveying strong earthquakes. The last witness belongs to Turkey's event of February 2023. In this paper, an experimental investigation on RC beam--column joints under bi--axial load condition is presented. Three full--scale beam--column joints were tested both in as--built and retrofit condition. Haunch retrofit was employed for the latter. Tests were carried out using hexagonal displacement protocol which is essentially to apply load in one direction double with respect to the other. Results obtained for as--built condition were included in a database of corner joints tested bi--axially and discussed in the light of the impact of bi--axial load on joint's shear strength. Numerical analyses using brick finite elements were employed to thoroughly evaluate the coupled structural response. Bi--axial shear demand proved to be detrimental but mitigation effect of joint's confinement was proved as well therefore conclusive statement on the subject was not reached. Haunch retrofit proved to satisfactorily reduce the shear demand at joint. Experimentally--derived internal forces were used to validate Strut-and-Tie models of the joints. Such design tool is recommended for practice cases adopting haunch retrofit.
Outward oriented gravitational attraction in the innermost part of the compact objects - new, always-present property of relativistic gravity and its consequences
Authors: Neslu\v{s}an Lubo\v{s} 
Published: May 2023

Abstract
We point out a new property of general-relativistic gravity:in reality, the gravity in the innermost region of relativistic compactobjects (RCOs) is oriented outward from the object's center. We explainhow an attractive gravity can result in such the orientation. Further,we point out an erroneous identification of a tensor with a scalarwithin the old RCO concept. This misidentifying caused that almostwhole general relativity (GR) was forbidden in the astrophysics of RCOs;the Oppenheimer-Volkoff upper-mass limit is a consequence of thisprohibition. Our analysis of RCO properties, derived from some modelsthat were constructed by using unlimited GR, indicates that gaseous RCOsare the objects in the form of hollow sphere with an inner physicalsurface. Its radius can be whatever small (but never exactly zero), andthis has been, likely, the reason of why the phenomenon of the outwardoriented gravity has escaped our attention. One can also model thesuper-massive RCOs, the nuclei of which resemble the objects found inthe centers of galaxies and quasars. Perhaps, the most importantproperty of a super-massive RCO is the fact that the energy content ofthe RCO nucleus appears to be several orders of magnitude larger thanderived from a gravitational action. In conclusion, we argue that thereis no reason to demand that only the normalized solutions of the fieldequations, implying the RCOs in the form of quasi-fulfilled sphere andwith an upper mass limit, can be used in the modeling of the stableRCOs.
Biotechnology patenting: Limits of ordre public and morality provisions
Authors: Mafu Mhlambululi 
Published: May 2023

AbstractThe world is experiencing explosive technological progress in biotechnology, leading to unprecedented benefits such as improved or new medicines, treatments, and processes with the potential to transform and save human lives. However, as novel technological frontiers are crossed, there have been increased concerns about how biotechnology inventions are granted or refused exclusive patent protection. Besides meeting patentability requirements, various countries consider most biotechnology inventions contrary to their ordre public and morality provisions and exclude them from protection using intellectual property rights. Notably, the meaning of these provisions is dynamic and varies from jurisdiction to jurisdiction, thus affecting the patentability of biotechnology inventions. Adopting the doctrinal research approach, we comparatively study various case laws, statutes, and legal sources from international, national and regional patent laws, including the impact of patent flexibilities on biotechnology inventions. Furthermore, we investigate the limit imposed by ordre public or morality provisions as grounds to refuse to grant biotechnology patents to benefit the community’s interest and invalidate it for the inventor. We review the current landscape for ordre public and morality limits on the patentable subject matter by analyzing relevant patent disputes and the impact of the decisions. We argue that ordre public and moral exclusions or exceptions have become entangled in Patent Law, so they must be interpreted and applied such that their outcomes do not hamstring patent granting for disruptive biotechnology inventions because of their more expansive ethical, societal, and legal effects. Moreover, this might require a critical demand to deal with controversial biotechnological issues on case-by-case decisions instead of a broad, inflexible, and comprehensive ban. While there is a need to adapt the ordre public and morality exclusions to accommodate biotech inventions, Patent Officers and Courts must be resourced to handle these exclusions. Most significantly, this study exposes the interplay and impact between patent laws as a commercial tool and the role of regulatory systems in the administration of biotechnology inventions. This is crucial to ensure fair and equal access to the merits of using biotechnologies for scientific development.
Analysis of depression incidence and influencing factors among middle-aged and elderly diabetic patients in China—Based on CHARLS data
Authors: BAI SHUO , Wang Jinsong , Liu jinteng , miao yamin , Zhang anqi , Zhang ziyi 
Published: May 2023

Abstract
Objective
To investigate the incidence of depression in middle-aged and elderly diabetic patients in China and the influencing factors, in order to provide a theoretical basis for improving the mental health of middle-aged and elderly diabetic population and formulating prevention, control and intervention strategies.
Methods
The sample of this study was obtained from the China Health and Aging Tracking Survey (CHARLS) 2018 survey data, and middle-aged and older diabetic patients aged 45 years and above were selected as the study subjects (n=2613 ), and the depressive symptoms of the study subjects were determined by using the simplified version of the Depression Scale for Epidemiological Surveys (CES-D) scores, and the influence factors were analyzed by binary logistic regression, and the proportion of depressive symptoms was standardized by the sex ratio of the seventh census.
Results
Among 2613 middle-aged and elderly diabetic patients, 1782 (68.2%) had depressive symptoms and 831 (31.8%) had no depressive symptoms, and the depression rate among middle-aged and elderly Chinese diabetic patients after standardization correction was 67.5%. Binary logistic regression results showed that age, education level, life satisfaction, marital satisfaction, self-rated health grade, somatic pain, visual impairment, physical disability, and the presence of comorbid chronic diseases were factors influencing the onset of depression in Chinese middle-aged and elderly diabetic patients (P < 0.05).
Conclusion
According to the survey analysis of CHARLS 2018 data, depressive symptoms are more serious among middle-aged and elderly diabetic patients in China, and depression is influenced by a combination of factors. Therefore, for this population of middle-aged and elderly diabetic patients, targeted prevention and control should be carried out for key populations such as middle-aged and elderly people, poor physical health, and low life satisfaction and marital satisfaction from various dimensions such as demographic and sociological factors, physical health status, and life satisfaction and marital satisfaction.
An Optimal Multipath Routing for Data Transmission Using Bird Swarm Algorithm
Authors: B Shunmugapriya , A Shenbagharaman , M Ms.Pappathi Jancy Rani 
Published: May 2023

Abstract
A Vehicular Ad-Hoc Network (VANET) collects wireless nodes that dynamically swap information among them and with the Road Side equipment without relying on a predetermined base station or a wired medium. Every node in the VANET is equipped with sensors that allow it to sense its environment and relay relevant details, such as a notice to neighbouring nodes in case of emergency. At first, the vehicles are deployed in a Highway Environment. The nodes can be clustered using the fuzzy clustering logic to obtain better scalability and stability. The header node is chosen for network administration. Cluster Header is capable for sending and gathering data from cluster member nodes to the intended recipient. Multipath routing protocols improve trustworthiness and fault tolerance. In this paper, a Bird Swarm Algorithm (BSA) is proposed to establish the best possible multipath for broadcasting the data from sender to the receiver in the network. This research was experimented by using Network Simulator version 2. The multipath is best selected using the AOMDV routing strategy based on the fitness metric (Trust, Throughput and Connectivity). The results are contrasted with those of the currently used methods. Regarding parameters like PDR, E2E delay, throughput, overhead, and PLR. The proposed work performs better while comparing with other algorithms.