bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual-related determinants of life satisfaction among married women: A cross-sectional study
Authors: Bahrami Nasim , Hosseini Mobina , Griffiths Mark D. , Alimoradi Zainab 
Published: April 2023

AbstractBackground and aimLife satisfaction refers to the perceived satisfaction of individuals concerning various aspects of their lives. The present study investigated the predictive role of sexual-related determinants in life satisfaction among married women.MethodsA cross-sectional study was conducted from August to November 2021. A total of 350 married women with at least six months of cohabitation with husbands were included in the study. The study utilized a multi-stage random sampling method from 10 comprehensive health centers in Qazvin, Iran. Scores on the Emotional Intimacy Questionnaire (EIQ), Dyadic Sexual Communication Scale (DSCS), Female Sexual Distress Questionnaire (FSDQ), Female Sexual Quality of Life Scale (FSQLS), Female Sexual Function Index (FSFI), and Life Satisfaction Scale (LSS) were assessed. Data were analyzed using univariable and multivariable linear regression models with a significance level ofp < 0.05.ResultsThe mean age of participants was 33.77 years (SD = 9.77) and they had been married for an average of 10.21 years (SD = 9.93). The mean scores on the LSS were 20.16 (out of 35; SD = 6.79). Based on the multivariable linear regression model adjusted for socio-demographic characteristics, the two strongest predictors of life satisfaction among Iranian married women were marital intimacy (β = 0.49,p < 0.001) and sexual functioning (β = 0.17,p = 0.009). Together, these variables explained 45% of variance in life satisfaction.ConclusionGiven that marital intimacy and sexual functioning were the most significant sexual-related determinants of life satisfaction among married women, designing and implementing interventions which increase women’s marital intimacy and sexual functioning might improve married women’s life satisfaction.
Effects of empowerment education on the self-management and self-efficacy of liver transplant patients: a randomized controlled trial
Authors: Guo Limin , Li Lezhi , Lu Yanfang , Li Ting , Chen Linjun , Jiang Liya , Zhang Shihan , Yuan Meijiao 
Published: April 2023

Abstract
Background
Despite the increasing survival rates, liver transplant patients experience numerous postoperative complications and encounter significant challenges in long-term self-management. This study aims to examine the effectiveness of empowerment education in enhancing self-management skills and self-efficacy among liver transplant recipients.

Methods
A randomized, single-blind, single-center trial was conducted in China between August 2019 and September 2020, involving liver transplant recipients. The intervention group received 12 weeks of empowerment education, while the control group received 12 weeks of routine education. .The study assessed the patients’ self-management and self-efficacy using the Liver Transplant Recipient Self-Management Questionnaire and the Self-efficacy for Managing Chronic Disease 6-Item Scale. Follow-up assessments were conducted at 1, 3, and 6 months after the intervention.

Results
Eighty-four patients were initially randomized to either the intervention group (n1 = 42) or the routine education group (n2 = 42). Twelve patients were excluded from the analysis due to loss of follow-up or discontinuation of the intervention, leaving 72 patients (n1 = 35, n2 = 37) for the final analysis. The scores for exercise and lifestyle management were significantly higher in the intervention group than in the control group at 1, 3, and 6 months after the intervention (t = 3.047, 5.875, 8.356, and t = 5.759, 4.681, 11.759, respectively; P < 0.05). At 3 and 6 months after the intervention, the scores for cognitive symptom management, communication with physicians, and self-efficacy were significantly higher in the intervention group than in the control group (t = 5.609, 6.416, and t = 5.576, 11.601, and t = 6.867, 15.071, respectively; P < 0.001). Within the intervention group, self-management scores increased significantly over time, while within the control group, the scores for communication with physicians, lifestyle, and self-efficacy showed a significant decline from 3 to 6 months after routine health education.

Conclusions
The results of this study suggest that empowerment education is an effective means of improving the self-management and self-efficacy of liver transplant patients, with better outcomes compared to routine health education. These findings have important implications for nursing practice and provide valuable guidance for clinical education of liver transplant patients.

Trial registration
ChiCTR2200061561.
Facilitators and barriers of the implementation of point-of-care devices for cardiometabolic diseases: a scoping review
Authors: Tenorio-Mucha Janeth , Busta-Flores Patricia , Lazo-Porras María , Vetter Beatrice , Safary Elvis , Moran Andrew E. , Gupta Reena , Bernabé-Ortiz Antonio 
Published: April 2023

Abstract
Background
Point-of-care testing (POCT) devices may facilitate the delivery of rapid and timely results, providing a clinically important advantage in patient management. The challenges and constraints in the implementation process, considering different levels of actors have not been much explored. This scoping review aimed to assess literature pertaining to implementation facilitators and barriers of POCT devices for the diagnosis or monitoring of cardiometabolic diseases.

Methods
A scoping review of the literature was conducted. The inclusion criteria were studies on the inception, planning, or implementation of interventions with POCT devices for the diagnosis or monitoring of cardiometabolic diseases defined as dyslipidemia, cardiovascular diseases, type 2 diabetes, and chronic kidney disease. We searched MEDLINE, Embase, and Global Health databases using the OVID searching engine until May 2022. The Consolidated Framework of Implementation Research (CFIR) was used to classify implementation barriers and facilitators in five constructs. Also, patient, healthcare professional (HCP), and organization level was used.

Results
Twenty studies met the eligibility criteria for data extraction. All studies except two were conducted in high-income countries. Some findings are: 1) Intervention: the most widely recognized facilitator was the quick turnaround time with which results are obtained. 2) Outer setting: at the organizational level, the lack of clear regulatory and accreditation mechanisms has hindered the adoption and sustainability of the use of POCT. 3) Inner setting: for HCP, performing POCT during the consultation was both a facilitator and a barrier in terms of time, personnel, and service delivery. 4) Individuals: the implementation of POCT may generate stress and discomfort in some HCP in terms of training and new responsibilities. 5) Process: for patients, it is highly appreciated that obtaining the sample was simple and more comfortable if venipuncture was not used.

Conclusion
This scoping review has described the facilitators and barriers of implementing a POCT device for cardiometabolic conditions using the CFIR. The information can be used to design better strategies to implement these devices and benefit more populations that have low access to cardiometabolic tests.
Apoptosis related genes mediated molecular subtypes depict the hallmarks of the tumor microenvironment and guide immunotherapy in bladder cancer
Authors: Zhou Liquan , Xu Guanglong , Huang Fu , Chen Wenyuan , Zhang Jiange , Tang Yong 
Published: April 2023

AbstractApoptosis has been discovered as a mechanism of cell death. The purpose of this study is to identify the diagnostic signature factors related to bladder cancer (BLCA) through apoptosis related genes (ARGs). Clinicopathological parameters and transcriptomics data of 1,440 BLCA patients were obtained from 7 datasets (GSE13507, GSE31684, GSE32548, GSE32894, GSE48075, TCGA-BLCA, and IMvigor210). We first identified prognosis-related ARGs in BLCA and used them to construct two ARGs molecular subtypes by using consensus clustering algorithm. By using principal component analysis algorithms, a ARGscore was constructed to quantify the index of individualized patient. High ARGscore correlated with progressive malignancy and poor outcomes in BLCA patients. High ARGscore was associated with higher immune cell, higher estimate scores, higher stromal scores, higher immune scores, higher immune checkpoint, and lower tumor purity, which was consistent with the “immunity tidal model theory”. Preclinically, BLCA immunotherapy cohorts confirmed patients with low ARGscore demonstrated significant therapeutic advantages and clinical benefits. These findings contribute to our understanding of ARGs and immunotherapy in BLCA. The ARGscore is a potentially useful tool to predict the prognosis and immunotherapy in BLCA.
Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma
Authors: Li Ying , Tai Zongguang , Ma Jinyuan , Miao Fengze , Xin Rujuan , Shen Cuie , Shen Min , Zhu Quangang , Chen Zhongjian 
Published: April 2023

Abstract
Background
Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments for cSCC are associated with limited penetrating ability to achieve the desired outcome. Therefore, there remains an urgent requirement to develop drugs with efficient anticancer activity suitable for treating cSCC and to overcome the skin physiological barrier to improve the efficiency of drug delivery to the tumor.

Results
We introduced lycorine (LR) into the topical treatment for cSCC and developed a cell-penetrating peptide (CPP)-modified cationic transfersome gel loaded with lycorine-oleic acid ionic complex (LR-OA) (LR@DTFs-CPP Gel) and investigated its topical therapeutic effects on cSCC. The anti-cSCC effects of LR and skin penetration of LR-OA transfersomes were confirmed. Simultaneously, cationic lipids and modification of R5H3 peptide of the transfersomes further enhanced the permeability of the skin and tumor as well as the effective delivery of LR to tumor cells.

Conclusions
Topical treatment of cSCC-xenografted nude mice with LR@DTFs-CPP Gel showed effective anticancer properties with high safety. This novel formulation provides novel insights into the treatment and pathogenesis of cSCC.
The relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted to hospital with COVID-19
Authors: McGovern Josh , Wadsworth John , Catchpole Anthony , Richards Conor , McMillan Donald C. , Kelliher Tadhg , Goodall Emma , Murray Ellie , Melaugh Terry , McPhillips Shannon , Brice Kathryn , Barbour Katie , Robinson Sophie , Moffitt Peter , Kemp Olivia , Talwar Dinesh , Maguire Donogh 
Published: April 2023

Abstract
Background
Micronutrients have been associated with disease severity and poorer clinical outcomes in patients with COVID-19. However, there is a paucity of studies examining if the relationship with micronutrient status and clinical outcomes is independent of recognised prognostic factors, specifically frailty and the systemic inflammatory response (SIR). The aim of the present study was to examine the relationship between micronutrient status, frailty, systemic inflammation, and clinical outcomes in patients admitted with COVID-19.

Methods
Retrospective analysis of prospectively collected data was performed on patients with confirmed COVID-19, admitted to hospital between the 1st April 2020–6th July 2020. Clinicopathological characteristics, frailty assessment, biochemical and micronutrient laboratory results were recorded. Frailty status was determined using the Clinical Frailty scale. SIR was determined using serum CRP. Clinical outcomes of interest were oxygen requirement, ITU admission and 30-day mortality. Categorical variables were analysed using chi-square test and binary logistics regression analysis. Continuous variables were analysed using the Mann–Whitney U or Kruskal Wallis tests.

Results
281 patients were included. 55% (n = 155) were aged ≥ 70 years and 39% (n = 109) were male. 49% (n = 138) of patients were frail (CFS > 3). 86% (n = 242) of patients had a serum CRP > 10 mg/L. On univariate analysis, frailty was significantly associated with thirty-day mortality (p < 0.001). On univariate analysis, serum CRP was found to be significantly associated with an oxygen requirement on admission in non-frail patients (p = 0.004). Over a third (36%) of non-frail patients had a low vitamin B1, despite having normal reference range values of red cell B2, B6 and selenium. Furthermore, serum CRP was found to be significantly associated with a lower median red cell vitamin B1 (p = 0.029).

Conclusion
Vitamin B1 stores may be depleted in COVID-19 patients experiencing a significant SIR and providing rationale for thiamine supplementation. Further longitudinal studies are warranted to delineate the trend in thiamine status following COVID-19.
Perspectives on sexual and reproductive health self-care among women, healthcare providers, and other key informants: a mixed-methods study in South Africa and Zambia
Authors: Cartwright Alice F. , Velarde Marissa , Beksinska Mags , Smit Jennifer , Kasaro Margaret , Tang Jennifer H. , Milford Cecilia , Maphumulo Virginia , Chinyama Manze , Chabu Esther , Mudenda Mayaba , Wong Christina , Fawzy Maria , Callahan Rebecca 
Published: April 2023

Abstract
Background
“Self-care” for sexual and reproductive health (SRH) includes contraceptive methods and other supplies that people can use with or without the support of a healthcare provider. Self-administered tests, self-injection of injectable contraception, or self-removal of intrauterine devices (IUDs) can increase people’s access to and autonomy over their own SRH. Objectives of this study were to assess women’s current interest in and use of SRH self-care and explore key informants’ (KI) opinions of self-care, especially during the COVID-19 pandemic.

Methods
Data for this study came from female participants in the longitudinal Contraceptive Use Beyond ECHO (CUBE) study, and KIs, including healthcare providers, in South Africa and Zambia between September 2020 and June 2021. For this analysis, we used data from a participant phone survey (n = 537), and from in-depth interviews (IDIs) completed with a sub-sample of women (n = 39) and KIs (n = 36). Survey data were analyzed with descriptive statistics, and IDI data were analyzed using applied thematic analysis.

Results
Female survey participants in South Africa were more interested in learning about emergency contraceptive pills, subcutaneous injectable contraception, and CycleBeads, while Zambian participants wanted more information and access to condoms. However, in IDIs in both countries, women described minimal experience with self-care beyond condom use. In the Zambian KI IDIs, COVID-19 led to increased self-care counseling on subcutaneous injectable contraception and HIV self-testing. KIs who do not counsel on self-care were concerned that women may harm themselves or blame the provider for difficulties. Two KIs thought that women could possibly self-remove IUDs, but most expressed concerns. Reported barriers to self-care included COVID movement restrictions, transport costs, lack of accessible pharmacies, women’s low awareness, and possible stigma.

Conclusions
Women surveyed reported interest in learning more about SRH self-care methods and resources, but in IDIs did not report extensive previous use besides condoms. KIs described some concerns about women’s ability to use self-care methods. Counseling on and provision of self-care methods and supplies may have increased during the COVID-19 pandemic, but ensuring that self-care is more than just a temporary measure in health systems has the potential to increase access to SRH care and support women’s autonomy and healthcare needs.
The association between the multiple birth and breast cancer incidence: an update of a systematic review and meta-analysis from 1983 to 2022
Authors: Veisi Pedram , Nikouei Maziar , Cheraghi Mojtaba , Shahgheibi Sholeh , Moradi Yousef 
Published: April 2023

AbstractBackgroundIt has been assumed that perinatal factors such as multiple pregnancies may affect subsequent breast cancer risk in the mother. Considering the inconsistencies in the results of case-control and cohort studies published in the world, this meta-analysis was conducted in order to determine the exact association between multiple pregnancies (twins or more) and the breast cancer incidence.MethodsThis study was performed as a meta-analysis based on PRISMA guidelines by searching the international databases of PubMed (Medline), Scopus, and Web of Science as well as by screening selected articles based on their subject, abstract and full text. The search time was from January 1983 to November 2022. Then the NOS checklist was used to evaluate the quality of the final selected articles. The indicators considered for the meta-analysis included the odds ratio (OR) and the risk ratio (RR) along with the confidence interval reported in the selected primary studies. The desired analyzes were performed with STATA software version 17 to be reported.ResultsIn this meta-analysis, 19 studies were finally selected for analysis, which fully met the inclusion criteria. Of these, 11 were case-control studies and 8 were cohort ones. Their sample size was 263,956 women (48,696 with breast cancer and 215,260 healthy) and 1,658,378 (63,328 twin or multiple pregnancies and 1,595,050 singleton pregnancies), respectively. After combining the results of cohort and case-control studies, the effect of multiple pregnancies on the breast cancer incidence was equal to 1.01 (95% CI: 0.89–1.14; I2: 44.88%, P: 0.06) and 0.89 (95% CI: 0.83–0.95; I2: 41.73%, P: 0.07), respectively.ConclusionThe present meta-analysis results showed, in general, multiple pregnancies were one of the preventive factors of breast cancer.
Does agrivoltaism reconcile energy and agriculture? Lessons from a French case study
Authors: Carrausse Romain , Arnauld de Sartre Xavier 
Published: April 2023

Abstract
Background
Agrivoltaism is presented as an innovative production system that may combine agricultural activity and energy production on the same parcel of land. The deployment of this innovation has already begun in France as part of the energy transition initiatives, and many actors consider that its deployment only depends on social acceptance issues. However, given that agrivoltaism cuts across the agricultural and energy sectors, social, technical, and political concerns have arisen. While these concerns are primarily reflected in conflict and opposition, the problem goes far beyond the simple question of social acceptance. Indeed, it relates to the dynamics of innovation and governance, structured in different arenas at different scales that shape how this innovation is deployed.

Methods
The authors conducted a qualitative study revolving around three methodological approaches: a press analysis, a review of scientific literature, and fieldwork in the Pyrénées-Atlantiques district in France. Drawing on the case of a disputed project, several semi-structured interviews were conducted. These interviews explored how the public sector, institutions, energy companies, and local farmers perceive the development of agrivoltaics and how they organise the dynamics of governance to control its deployment.

Results
Our analysis highlights four main results: (i) agrivoltaism is an innovation conceptualised in techno-scientific arenas which seek to define its agricultural viability; (ii) at the national level, the remote control by the State does not provide a framework for governance capable of involving the various actors in the fields of agriculture and energy; (iii) the deployment of agrivoltaism systems across regions engenders conflict while placing key local actors in a situation of uncertainty with regard to how best to manage this innovation; (iv) while individuals are subjected to territorialisation, this paradoxically favours structural policy innovations which outline the contours of territorial governance.

Conclusions
This study shows that agrivoltaism is the result of interactions between techno-scientific actors in the energy and agricultural fields. However, its political backing in France does not promote dynamics of governance capable of bringing these two fields together. At the local level, the deployment of agrivoltaism has faced opposition, but it has also led to the organisation of territorial governance strategies involving actors and institutions from different sectors.
New approaches to idiopathic neutropenia in the era of clonal hematopoiesis
Authors: Ogbue Olisaemeka D. , Kewan Tariq , Bahaj Waled S. , Gurnari Carmelo , Visconte Valeria , Maciejewski Jaroslaw P. 
Published: April 2023

AbstractIsolated chronic idiopathic neutropenia (CIN) is a rare disease with multiple contributing etiologies that must be ruled out before establishing a diagnosis. We studied clinical and molecular data of 238 consecutive adult patients with CIN. Autoimmune neutropenia was present in 28% of our cohort. In contrast, T cell-mediated neutropenia was the main underlying pathological mechanism among patients with T cell expansions, such as T-cell large granular lymphocytic leukemia (T-LGL) and T cell clonopathy of undetermined significance, found in 37% and 8% of cases, respectively. Patients with neutropenia also had hypogammaglobulinemia (6%) and/or monoclonal gammopathy of undetermined significance (5%). NGS application has further broadened the spectrum of causes of CIN by including manifestations of clonal hematopoiesis, present in 12% of cases. TET2 (3%), TP53 (2%), and IDH1/IDH2 (2%) mutations were the most commonly found and were enriched in cases with T-LGL. We show that these clinico-molecular associations can be simultaneously present, complicating a proper diagnostic distinction within the broader entity of seemingly idiopathic neutropenia of autoimmune origin. Identification of etiologic culprits may also guide rational selection of therapies.
The development and effectiveness of web-based psychological capital intervention on the mental well-being of tourism workers during the COVID-19 pandemic
Authors: Sumalrot Thanayot , Suwanwong Charin , Pimthong Saran , Surakarn Amaraporn , Chiangkhong Araya , Khunakorncharatphong Anon 
Published: April 2023

AbstractThe current COVID-19 situation has forced many tourism businesses to close. Tourism workers have suffered chronic stress, discouragement, despair, and failure to find solutions for their businesses, resulting in deteriorating mental health. A psychological capital intervention (PCI) is therefore deemed necessary as it promotes the mental well-being of tourism workers. This article reports the development of a web-based PCI for the mental well-being of tourism workers and an investigation of its effectiveness using a mixed-methods intervention design. A qualitative approach was used to develop the intervention by conducting interview techniques with 20 tourism entrepreneurs. A content analysis was carried out. The intervention was tested through an experimental research design. The sample comprised 600 tourism workers who undertook a web-based PCI. Data on their mental well-being were collected before the intervention and 1 month afterward and analyzed using ANCOVA. The research revealed that 4 themes are needed for the intervention: having a goal, tolerance of difficulties, inspiration from a role model, and the appropriate way of thinking. An effectiveness examination showed that the web-based PCI improves mental well-being scores significantly. In conclusion, this web-based PCI, which focuses on developing strengths, effectively improves the mental well-being of tourism workers facing difficulties during the COVID-19 pandemic.