bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Ventricular-Vascular Interactions Associated with Aerobic Capacity
Authors: Morrison Barbara N. , Mittermaier Peter M. , Lester Garth , Bodner Michael , Cote Anita 
Published: June 2023

Abstract
Background: Aerobic capacity as measured by peak oxygen uptake (VO2peak), is related to functional capacity and is a strong independent predictor of all-cause and disease-specific mortality. Lifelong exercise is associated with reduced central arterial and ventricular stiffness, potential mechanisms that may underpin cardiovascular health benefits as a result of endurance training. The purpose of this study was to evaluate sex-specific ventricular-vascular interactions associated with VO2peak in healthy males and females.
Methods: Sixty-eight males and females (35 10 years) characterized as recreational exercisers to highly trained endurance athletes, and free of chronic disease underwent a cycle ergometer test to exhaustion to assess aerobic capacity (VO2peak). Resting arterial compliance and echocardiographic evaluation of left ventricular (LV) function were measured.
Results: VO2peak was similar between groups (54 6 vs. 50 7). LV mass indexed to body surface area (LVMI) was higher (110 20 vs. 94 18, p=0.001) and longitudinal diastolic strain rate was lower (1.6 0.3 vs. 1.4 0.2, p=0.005) in males. Linear regression analysis revealed LVMI and longitudinal diastolic strain rate were significantly associated with VO2peak (r2=0.32, p=0.001) in males, while in females LVMI and large artery compliance were the key factors influencing VO2peak (r2=0.61, p<0.001).
Conclusion: These findings reveal that in females much of the variance in VO2peak can be attributed to ventricular and vascular adaptations, whereas in males, cardiac factors of structure and function accounted for the majority of this variance. The substantive central vascular adaptations to exercise observed in females in this study further validates engagement in endurance training to prevent age-related arterial stiffening in women.
A Study on the Classification of Geological Background Source Cadmium Migration Phases in Zhejiang Provence, China
Authors: Zhou Wenda , Lu Xinze , Huang Chunlei , Wang Jinghe , Guo Kegan , Xie Shuyun 
Published: June 2023

Abstract
The release of cadmium during the natural weathering process of cadmium-containing strata constitutes a significant source of cadmium pollution in both water and soil. The Hetang Formation, located in western Zhejiang Province in China, is a typical example of a cadmium-rich black shale stratum. The bottom coal seam of this formation has been found to contain high levels of cadmium, with concentrations reaching up to 11.2 mg/kg. The continuous weathering and erosion of cadmium-bearing bedrock by fluvial processes results in the release of cadmium, leading to geological background cadmium contamination of downstream soils. This study relies on the strong adsorption characteristics of iron-sediment for cadmium during migration and uses FE-SEM, EDS, optical microscopes and other means to observe the distribution of iron elements in rock fragments of different weathering degrees in the Hetang Formation in river channels. The aim is to explore the state of cadmium from geological background sources during migration. By comparing detritus from upstream and downstream sections of the river channel, it was determined that under weathering conditions, the occurrence state of geological background source cadmium could be divided into three distinct stages: unweathered stage; intra-detritus migration stage; and completely weathered stage. Furthermore, after leaving the Hetang Formation shale outcrop area, there was a sharp decrease in content for Hetang Formation detritus. At this point geological background source cadmium had largely escaped from constraints imposed by rock structure and had come into full contact with water. The findings from this research deepen our understanding regarding migration patterns for geological background source cadmium. They also reveal formation processes for geological background source cadmium pollution and provide a theoretical basis for identification and treatment for geological background source cadmium pollution.
Synthesis, Structural Characterization, XRD Analysis, Hirshfeld Surface Analysis, and Biological Studies of New Fe(II) and Cu(II) complexes of 2-acetyl pyridine derivative sulfonyl hydrazone Schiff Base
Authors: Çınarlı Murat , Ataol Çiğdem Yüksektepe , Öğütçü Hatice , Açık Leyla , Bati Humeyra 
Published: June 2023

Abstract
It is known that sulfonyl hydrazones and their metal complexes may have potential biological activity. We have prepared new Fe(II) (1) and Cu(II) (2) complexes of 2-acetyl pyridine derivative sulfonyl hydrazone (LH). The new metal complexes were characterized by elemental analysis, IR spectra, UV spectra, and magnetic moment measurements. The molecular structure of (2) was elucidated by X-ray diffraction analysis and the crystal package in three-dimensional space was obtained. To support the intermolecular interactions obtained from X-ray diffraction results, Hirshfeld surface analysis and two-dimensional fingerprint maps of (2) were generated. It was determined that H...H (47.4%), H...C/C...H (25.8%), H...O/O...H (17.4%), and H...N/N...H (8%) interactions will play an effective role in the crystal packing of the molecule. From elemental analysis data, the stoichiometries of (1) and (2) were found to be 1:2 (metal/ligand). All data indicated that the ligand coordinated with metal atoms through pyridine nitrogen, imine nitrogen, and sulfonyl oxygen. The well-diffusion approach was also used to test the ligand and the complexes for their antibacterial properties against harmful microbes. The substances were tested for DNA cleavage using the agarose gel electrophoresis technique. The complex (1) was found to be effective on the plasmid DNA of pBR322.
Rare acute pulmonary thromboembolism after internal fixation for isolated multiple rib fractures: a case report
Authors: Xu Bao-ping , Yang Hao , Pen Huai-wen , Zhu Sen , Li Zhen-jun , Wang Xiao-tao 
Published: June 2023

Abstract
Background
Multiple rib fractures are common in emergency trauma patients with high mortality. Acute pulmonary thromboembolism (PTE) is rare and has not been reported in patients with isolated multiple rib fractures after surgical stabilization of rib fractures (SSRF). We report a case of a 64-year-old patient presenting with PTE after SSRF due to non-standardized anticoagulant therapy; it should attract enough attention from thoracic surgeons.
Case presentation
A 64-year-old male was admitted to our hospital with multiple rib fractures, pulmonary contusion, bilateral pleural effusion, and incomplete right lung expansion. The patients were treated on the sixth day of their hospitalization with thoracoscopic exploration combined with internal fixation of the right fracture of the sixth to eighth ribs. He started anticoagulant therapy 48 h after the operation to prevent deep vein thrombosis with low molecular weight heparin 2500 units once daily. He gradually recovered from the operation, and his symptoms improved. The patient was diagnosed with acute PTE based on pulmonary artery angiography of CT on the fourth day after surgery; since that time, he has been treated with a subcutaneous injection of 60 mg enoxaparin every 12 h. After two weeks of anticoagulant therapy, they were discharged from the hospital and continued to receive oral anticoagulant therapy. The patient was followed up for three months after discharge, and everything was normal.
Conclusion
Acute PTE after isolated multiple rib fractures is rare; although SSRF is a relatively safe and effective treatment for multiple rib fractures with dislocation, perioperative deep vein thrombosis, including PTE and deep vein thrombosis, should be given sufficient attention by clinicians. The standardized prevention of perioperative venous thromboembolism for multiple rib fractures requires further research due to the lack of high-quality clinical evidence support.
A comparison of the epidemiological factors and burden of autism spectrum disorders worldwide and in China
Authors: Hai Yang , Muhammad Shan , Ain Qurat ul , Zou Mingyang , Liu Di , LiJie Wu 
Published: June 2023

Abstract
Objective
This study uses disability-adjusted life years to examine global and Chinese autism burden trends by year, age, gender, area, socioeconomic, environmental, and behavioral factors.
Methods
We analyzed ASD burden using 1990–2019 prevalence and DALYs. The Global Burden of Disease 2019 database provided global and national epidemiological data. Socioeconomic, environmental, and behavioral characteristics were correlated with age-standardized DALYs using linear regression.
Results
ASD DALYs increased by 39% globally and 14% in China from 1990 to 2019. The global ASD peak age for both men and women is 5, with numerous peaks of increasing tendencies in China at 5, 30, and 50 years. DALYs, incidence, and prevalence are 3–4 times higher in men. China had the most DALYs in 2019, and the UK had the most age-standardized. Countries differed in how ASD affected health. Socioeconomic factors considerably influenced age-standardized DALYs (GDP per capita, R2 = 0.305; HDI, R2 = 0.287; Health expenditure (% of GDP), R2 = 0.088; p < 0.05). ASD-related age-standardized DALYs were positively connected with per capita alcohol intake, negatively correlated with PM2.5, and insignificantly correlated with cigarette use prevalence.
Conclusions
Over the last 30 years, the health impact of ASD has steadily risen. It caused significant health loss, particularly for preschool children in households with a drinking habit from a higher socioeconomic level country.
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Authors: Vorobyeva Nadezhda E. , Krasnov Alexey N. , Erokhin Maksim , Chetverina Darya , Mazina Marina 
Published: June 2023

Abstract
Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. While the involvement of several IBPs in organising chromatin architecture in Drosophila has been described, the specific contribution of the Suppressor of Hairy wings (Su(Hw)) IBP to genome topology remains unclear. In this study, we provide evidence for the existence of long-range interactions (LRIs) between Su(Hw) and Combgap ChIP-Seq peaks, reflected in the indirect binding of these proteins to chromatin in ChIP experiments. Loss of Su(Hw) binding results in the disappearance of Su(Hw)-Combgap LRIs and a decrease in spatial self-interactions among a subset of Su(Hw) sites. Our findings suggest that Su(Hw)-Combgap LRIs are associated with active chromatin rather than Polycomb-directed repression. Furthermore, we observe that the majority of transcription start sites that are down-regulated upon loss of Su(Hw) binding to chromatin are located within 2 kb of Combgap peaks and exhibit Su(Hw)-dependent changes in Combgap and transcriptional regulators’ binding.
Tell me who you go with and I will tell you what you do: Antarctic seal lice behave differently
Authors: Soto Florencia Anabella , Crespo José , Negrete Javier , Leonardi María Soledad 
Published: June 2023

Abstract
Lice of the family Echinophthiriidae are obligate and permanent ectoparasites of pinnipeds and sea otters. Morphological, ecological, and behavioral adaptations have enabled them to survive in their amphibian hosts. However, it has been shown experimentally that the eggs do not survive submerged. This physiological limitation restricts their reproductive events to the terrestrial periods of their hosts, mainly during molting and reproduction. We studied the reproductive strategies of Antarctophthirus lobodontis on crabeater seals (CS, n = 54) and A. carlinii on Weddell seals (WS, n = 54) from Danco Coast, Antarctic Peninsula, during the molting season. Lice were sexed and classified as adults or nymphs under a stereomicroscope. The 20.37% of the CS had potentially viable eggs and all the nymphal stages and adults. However, in the WS we only found N3 and adults. Our results would suggest that A. lobodontis lays viable eggs that can survive immersion. Instead, the transmission of A. carlinii would be mainly by adults. According to previous studies, A. carlinii would reproduce during the reproductive season of WS. These reproductive strategies of seal lice would be related to the life history of their host, mainly to diving behavior and the haul-out patterns during their life cycle, reflecting the strong coadaptation and coevolution mechanisms between seals and lice. The differences in the population structure of the two species observed here may indicate that they are different species, or at least that they have undergone different co-evolutionary processes depending on the habit of their hosts.
Clinical features of ataxia with oculoapraxia type 2 in China
Authors: Tian Tian , Yang Junxia , Gao Meina 
Published: June 2023

Abstract
Background: Ataxia with oculomotor apraxia type 2 (AOA2) is very rare in China. This study aims to report on a Chinese girl with AOA2, and summarize the characteristics of Chinese AOA2 patients previously reported.
Methods: We compiled a series of seven previously reported and one novel ataxic patients who underwent senataxin gene (SETX) sequencing because of suspected AOA2. The clinical and molecular features of a series of Chinese AOA2 patients with proven SETX mutations were summarized.
Results: A novel homozygous missense mutation c.3455T>G (p.Phe1152Cys) in SETX was identified in a 17-year-old girl with ataxia, tremor, cervical dystonia and significantly elevated level of AFP (346 ng/mL). We reviewed a series of eight Chinese AOA2 patients from five families, including two males and six females. Onset of the disease occurred at an average age of 15.1 years, ranging from 10 to 20 years. The disease duration ranged from 3 to 24 years. The initial symptom was cerebellar ataxia in all cases (100%). Slurred speech and gaze nystagmus were present in six subjects (75%). None of the patients had OMA (0). One patient showed mild mental decline (12.5%). Cerebellar atrophy, pes cavus and polyneuropathy were found in 7 out of 8 cases (87.5%). Raised serum AFP levels were detected in five patients (62.5%). Extrapyramidal symptoms were found in three subjects (37.5%). Early-onset menopause was reported in one patient (12.5%). Five new mutations in the SETX were identified by molecular analyses. Among the variants, 10 homozygous or compound heterozygous variants in SETX were exonic, comprising 6 missense mutations, 2 nonsense mutations, 2 frameshift mutations.
Conclusions: This is the first reported AOA2 case in China, exhibiting tremor, cervical dystonia and high AFP, which broadens the spectrum of Chinese AOA2. The phenotype of Chinese AOA2 shows a higher frequency of pes cavus, lower percentage of AFP elevation and the absence of OMA in comparison with AOA2 patients worldwide. Future studies in a larger cohort are needed to validate these findings.
T cell invigoration is associated with the clinical response to anti-PD-1 based immunotherapy in non-small cell lung cancer
Authors: Wu Hui , Weng Gui zhen , Sun Lina , Pan Zhang chi , Zhang Lu , Chen Qiang , Shi Chun mei 
Published: June 2023

Abstract
Purpose: Immune checkpoint inhibitors (ICIs) have been developed for clinical application and proven effective for non-small cell lung cancer (NSCLC). Blockade of the programmed cell death 1 (PD-1) protein can partially reinvigorate circulating exhausted-phenotype CD8+ T cells (Tex cells) in preclinical models, however the clinical implication in anti-PD-1 based immunotherapy in NSCLC is unknown.
Methods: Serum specimens were obtained before and during treatment from 145 patients with NSCLC patients who received anti-PD-1 treatment and their prognosis was followed-up. Indicators such as cell subpopulations, T cell invigoration were detected by clinical laboratory testing. Kaplan-Meier analysis was performed to draw survival curves and Cox regression analysis to confirm the independent prognostic factors of NSCLC patients.
Results: The expressions of Ki-67 in PD-1+/CD8+ T cells in most NSCLC patients (97 of 145 cases) increased after treatment. The responding Ki-67+/CD8+ T cell population was mainly CD45RAlo CD27hi, containing cells with high expression of CTLA-4, PD-1, and 2B4 and low expression of NKG2-D (P<0.0001). The maximum fold change of Ki-67+/PD-1+/CD8+T cells in treatment cycles and the tumor burden determined by imaging were associated with better progression-free survival (PFS) and overall survival (OS). A Ki-67 expression to tumor burden ratio greater than 0.6 at the 1st cycle of anti-PD-1 immunotherapy was associated with improvement of PFS and OS (P<0.05).
Conclusion: Activation of circulating Tex cells before therapy related to tumor burden may be associated with clinical efficacy of anti-PD-1 immune therapy in NSCLC.
Enhancement of Stability on Dc Microgrid Using Dual Seires Virtual Impedance Based Fuzzy Controller Under Variation of Constant Power Load
Authors: Yadav Mukhraj , Singh Navdeep 
Published: June 2023

Abstract
This paper investigates the stability issue in direct current microgrid (DC MGs) due to linear and nonlinear constant power load (CPL). The deterioration can be damped out by inserting virtual resistances to minimize the impact of negative resistance of the CPL. However, large virtual resistances caused low stability region. This paper proposed a dual series virtual impedance with fuzzy logic-based voltage and current feed-forward controller. The dual series virtual impedance and a fuzzy logic (FL) are used for improvement of transient behaviour and steady-state error. However, the crossover frequency increased by inserting of CPL is minimized but, not much improved by virtual impedance controller. A fuzzy logic-based voltage and current feedforward controller moves from instable to stable region. With FL based current feedforward controller, the crossover frequency has been minimized from to 454 rad/sec to 23.8 rad/sec for 5 kW load. The feedforward current can not only improve the transient response but also mitigate the crossover frequency for small-signal modelling stability of microgrids. The comparative stability and transient performance have been demonstrated for variation of CPL (5–9 kW) and source. Different scenario variations of loads and source has been validated through simulated for power management by bidirectional converter.
Factors associated with the severity of actinic keratosis on face and scalp in a Brazilian sample: a cross-sectional study.
Authors: Gioppo Ingrid Stresser , Martins Ivanka Miranda de Castro , Santos Stefany S , Preto João Felipe Rossival , Miola Anna Carolina , Miot Helio Amante 
Published: June 2023

Abstract
Actinic keratosis (AK) is a skin condition associated with several risk factors, such as age, sun exposure, and immunosuppression. Certain drugs, such as photosensitizing medications and calcium channel blockers (CCBs), have also been linked to AK. Therefore, his study aims to explore the impact of individual, behavioural, and exposure factors on the severity of AKs on the face and scalp. A multicentre cross-sectional study was conducted on immunocompetent individuals with at least one AK on their face or scalp. The study assessed demographic factors, sun exposure and protection, smoking and alcohol use, personal and family history of skin cancer, and medication use within the last six months. The primary outcome was the Actinic Keratosis Area and Severity Index (AKASI) score, and a hierarchical generalized linear model was used to evaluate the variation in AKASI scores, adjusting for sex, age, and skin phototype. A total of 270 subjects aged between 39 and 92 years were evaluated, with a majority having phototype I or II (77%), male gender (51%), a personal history of skin cancer (55%), and low adherence to sunscreen use (29%). The use of photosensitizing medications was reported by 61% of the sample. Through multivariate analysis, older age (βSE = 0.14; p < 0.01), lighter skin phototype (βSE = 0.15; p = 0.01), a personal history of skin cancer (βSE = 0.12; p < 0.01), sunburning (βSE = 0.12; p < 0.01), and the use of CCBs (βSE = 0.11; p = 0.02) were identified as independent risk factors for AK severity. However, regular use of sunscreen was associated with less severe AK (βSE=-0.10; p = 0.03). Photosensitizing drugs, including hydrochlorothiazide, were not identified as risk factors. Older age, lower skin phototype classifications, and a personal history of skin cancer were confirmed as severity risk factors for AK, while adherence to sun protection was identified as a protective factor. The use of CCBs was associated with more severe AK.
Evaluation of the Properties of Secondary Side Current Rectifiers for Wireless Power Transfer System
Authors: Kindl V. , Zavrel M. , Tyrpekl M. , Frivaldsky M. , Skorvaga J. 
Published: June 2023

Abstract
Current tendencies in the field of charging systems are continuously attracted by the phenomenon of the wireless power charging. It is worth to say that within past decade, significant attention was spent on the research and development of various configurations of the transmitters, receivers, compensation networks and alternative solutions for the power circuits on the primary and/or secondary side of the system. In this paper the proposal for the performance optimization of the wireless power transfer (WPT) system is given. The solution is based on the alternative configuration of the secondary side rectifier. It is represented by diode rectifier with current doubler. Comparing to the bridge rectifier, two diodes are replaced by the inductors. Initially, a system analysis was performed to investigate electrical behavior and to find the most optimal conditions referred to terms of efficiency performance at nominal power. Due to this requirement the rectifier inductors must be designed according to meet this condition. The experimental verification was realized as well, while the proposed solution was compared to other common alternatives of the secondary side rectification. The load sensitivity analysis in terms of efficiency performance was realized as well, to observe system behavior for wide operation range. From the results is seen, that proposed alternative of the secondary side rectification of WPT system gives promising results in terms of high operating efficiency.
Shifting Learning Atmosphere through Process Drama: Teaching English POS in Indian Classrooms
Authors: Mahant Pratik Kumar , Alam Sohaib , Ghosh Sanjukta , Jabeen Ismat 
Published: June 2023

Abstract

This paper investigates the effectiveness of process drama in teaching English parts-of-speech to middle school students in an eastern Indian school. For the application part, we developed process drama-based lesson plans following the structural approach and implemented them among the students of class VII studying English as a second language. The study employed a quasi-experimental design, with a pretest-posttest approach to data collection. Additionally, the facilitator consistently took observational field notes to understand the utility and limitations of process drama in a second-language classroom. The twenty-day intervention program resulted in significant growth in the treatment group and showed seminal benefits over the traditional method of teaching parts-of-speech through the structural approach. Moreover, observational field notes indicated the welcoming attitude of learners towards process drama-based language pedagogy and assisted in understanding the utility and limitations of process drama as a pedagogical tool in a second language classroom. The findings of this study have implications for language educators, curriculum designers, and policymakers, offering valuable insights and practical recommendations for integrating process drama in L2 teaching methodologies in diverse educational settings.