bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modularisierung in der Prozessindustrie – Bericht von der ACHEMA 2022
Authors: Markaj Artan , Reiche Leif-Thore , Neuendorf Laura , Oeing Jonas , Klose Anselm 
Published: February 2023

AbstractAuf der ACHEMA 2022 wurden vielfältige Lösungen zur Modularisierung in der Prozessindustrie vorgestellt. In diesem Nachbericht werden insbesondere neue Bereiche der Modularisierung vorgestellt sowie Ergebnisse von Expertenbefragungen hinsichtlich der aktuellen und zukünftigen Herausforderungen der modularen Produktion beleuchtet. Obwohl in den letzten Jahren umfassende Fortschritte erzielt worden sind, stehen viele Unternehmen vor großen Herausforderungen, die nur in enger Zusammenarbeit von Modul‐ und Komponentenlieferanten, Anlagenbetreibern und Systemintegratoren sowie Anbietern von Automatisierungslösungen gemeistert werden können.
Removal of methylene blue and safranin orange pollutants from liquid effluents by soy residue
Authors: Natal Jean Paulo Silva , Cusioli Luis Fernando , Magalhães‐Ghiotto Grace Anne Vieira , Bergamasco Rosangela , Gomes Raquel Guttierres 
Published: February 2023

AbstractMethylene blue and safranin orange dyes, which are used in the textile and pharmaceutical industries, can severely damage the environment and human health. This study investigated the use of okara residue as an alternative biosorbent for the removal of methylene blue and safranin orange dyes. Substantial amounts of okara residue are generated daily during the processing of soy milk in the agro‐industrial sector. Dye adsorption was not affected by pH. An adsorption study identified the optimal experimental conditions as: 298 K, 0.03 g of adsorbent in 30 mL of dye solution at a concentration of 50 mg L−1, and a contact time of 300 min for methylene blue dye, and 298 K, 0.02 g of adsorbent in 30 mL of dye solution at a concentration of 50 mg L−1, and a contact time of 200 min for safranin orange dye; the maximum adsorption capacities were 93.201 ± 0.01 and 184 592 ± 0.02 mg g−1, respectively. Okara has considerable advantages over other natural materials as an alternative for the treatment of industrial effluents. Because it is easily obtained and does not require any physicochemical treatment, adsorption does not require any specific operation temperature. In addition, okara exhibited a high adsorption capacity compared to other natural materials that require chemical and physical processing for adsorbent preparation.
Identification of Drug Metabolites with Infrared Ion Spectroscopy – Application to Midazolam in vitro Metabolism**
Authors: van Outersterp Rianne E. , Martens Jonathan , Berden Giel , Lubin Arnaud , Cuyckens Filip , Oomens Jos 
Published: February 2023

AbstractThe identification of biotransformation products of drug compounds is a crucial step in drug development. Over the last decades, liquid chromatography‐mass spectrometry (LC‐MS) has become the method of choice for metabolite profiling because of its high sensitivity and selectivity. However, determining the full molecular structure of the detected metabolites, including the exact biotransformation site, remains challenging on the basis of MS alone. Here we explore infrared ion spectroscopy (IRIS) as a novel MS‐based method for the elucidation of metabolic pathways in drug metabolism research. Using the drug midazolam as an example, we identify several biotransformation products directly from an in vitro drug incubation sample. We show that IR spectra of the aglycone MS/MS fragment ions of glucuronide metabolites establish a direct link between detected phase I and phase II metabolites. Moreover, using quantum‐chemically computed IR spectra of candidate structures, we are able to assign the exact sites of biotransformation in absence of reference standards. Additionally, we demonstrate the utility of IRIS for structural elucidation by identifying several ring‐opened midazolam derivatives formed in an acidic environment.
Environmental color interventions on a macro scale: Tactical urbanism and issues of global concern
Authors: O'Connor Zena 
Published: February 2023

AbstractColor is a common design element in the built environment and is considered to have the capacity to elicit human response. In respect to environmental color interventions, outcomes tend to occur on a localized, microscale and relate to improving visual amenity, enhancing engagement and activation, and supporting initiatives relating to environmental visual literacy, wayfinding, orientation, and cultural diversity. Recently, a new type of color intervention has emerged. Relating to geopolitical issues of global concern, these occur on a “pop‐up” basis, carry a sense of immediacy, and relate to specific issues on a broader, crosscultural, macro scale. Falling under the category of tactical urbanism and representing a new form of environmental color intervention, this article identifies and documents two such interventions, both of which feature color as an integral element. In doing so, a secondary aim was to discuss the likely intended outcomes of these interventions. Adopting a case study methodology in tandem with a grounded theory qualitative approach, this investigation represents insight into this new form of environmental color intervention. Outcomes indicate that these interventions focus on communicating information aimed at initiating change on a global, macro scale. Future research will indicate the extent to which these aims are met.
Mechanism of the Early Catalytic Events in the Collagenolysis by Matrix Metalloproteinase‐1
Authors: Waheed Sodiq O. , Varghese Ann , DiCastri Isabella , Kaski Brenden , LaRouche Ciara , Fields Gregg B. , Karabencheva‐Christova Tatyana G. 
Published: February 2023

AbstractThe front cover artwork is provided by Dr. Karabencheva‐Christova's group at Michigan Technological University. The images show the initially formed and the catalytically productive conformations of MMP‐1 complex with the Triple Helical Peptide (THP), the free energy profile connecting them as well as the coordination geometry of the catalytic zinc (II). The background shows the collagen macromolecule. Read the full text of the Research Article at 10.1002/cphc.202200649.
Applicability of the Milan system for reporting salivary gland cytopathology: A single Brazilian institution experience
Authors: Tokunaga Juliana Akemi Dornellas , de Peres Eduardo Augusto Souza , Camilo‐Junior Deolino João , Xavier‐Junior José Cândido Caldeira 
Published: February 2023

AbstractIntroductionThe Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) emerged in 2015 as an attempt to establish protocols for a most appropriate follow‐up and treatment of patients with salivary gland lesions. Through fine needle aspiration (FNA), a safe and minimally invasive way to obtain cytological samples, the lesion is classified into one of the six categories, which have different risks of malignancy (ROM) and, therefore, different management.Materials and MethodsFNA cytology procedures performed between January 2016 and June 2020 (54 months) at the Pathology Institute of Araçatuba, São Paulo, Brazil, were analyzed by two pathologists with more than 5 years of experience. The ROM for each of the diagnostic categories was determines and compared with the ROM expected by the MSRSGC.ResultsA total of 99 FNA of salivary gland lesions were reviewed and retrospectively categorized. Histopathological follow‐up was available for 58 of 96 patients (60.42%). The patients age ranged from 23 to 98 years with the mean of 58.15 ± 15.29 years. The parotid gland was the most affected (81.82%). The average size of the lesions was 2.59 cm. The ROM for each category was 16.67%, 0%, 0%, 2.86%, 50%, 100%, 100%, respectively.ConclusionThis is the first Brazilian study describing the application of the MSRSGC in the routine of a private Laboratory out of a cancer center service. Therefore, it is an effective method in the classification of salivary gland lesions, when associated with the MSRSGC, to determine the ROM and its appropriate treatment.
Two cases of esophageal basaloid squamous cell carcinoma which achieved long‐term survival by endoscopic submucosal dissection and additional chemoradiotherapy
Authors: Morihisa Yoshiki , Iwagami Hiroyoshi , Akamatsu Takuji , Nakano Shogo , Wakita Midori , Edagawa Takeya , Konishi Takafumi , Nakatani Yasuki , Yamashita Yukitaka 
Published: February 2023

AbstractHerein, we report two rare basaloid squamous cell carcinoma (BSCC) cases. Esophagogastroduodenoscopy revealed a submucosal tumor‐like lesion and a biopsied specimen showed a finding suspected of BSCC in both cases. Both lesions underwent endoscopic submucosal dissection with en bloc resection, and long‐term survival was achieved using additional chemoradiotherapy. The standard treatment for BSCC has not been determined, and there are few reports of esophageal BSCC treated using endoscopic resection. Endoscopic submucosal dissection and additional chemoradiotherapy for superficial BSCC may be effective treatment options.
The effects of fresh mango consumption on gut health and microbiome – Randomized controlled trial
Authors: Asuncion Pia , Liu Changqi , Castro Robert , Yon Viviana , Rosas Martin , Hooshmand Shirin , Kern Mark , Hong Mee Young 
Published: February 2023

AbstractSome individual fruits have been widely researched for their effects on overall health and correlations with chronic diseases. The beneficial effects of mango supplementation on metabolic diseases have been detected. However, research into mango consumption on gut health, including the microbiome, is limited to processed mango preparations or peels. Our goal was to examine the effects of fresh mango consumption on the gut microbiome, gut permeability proteins, and bowel movement habits in overweight/obese individuals. In a 12‐week crossover design study, 27 participants consumed 100 kcal/day of either mangos or low‐fat cookies with a washout period of 4 weeks. The mango intervention showed higher Shannon–Wiener and Simpson alpha diversity indices of the microbiome than the low‐fat cookie intervention in week 4. Significant differences in beta diversity of the microbiome were found between diet interventions at week 12. Mango consumption increased the abundance of Prevotella maculosa, Corynebacterium pyruviciproducens, and Mogibacterium timidum while it decreased Prevotella copri. Low‐fat cookie intake increased Cyanobacterium aponinum and Desulfovibrio butyratiphilus and reduced Alloscardovia omnicolens. There were no significant differences in circulating gut permeability protein (ZO‐1, claudin‐2, and occludin) levels. There was a slight increase in the amount of bowel movement with mango consumption, but no significant findings for frequency, consistency, strain, pain, and constipation in bowel movement between trials. Given these results, it can be concluded that consumption of mango may have positive effects on the gut health, which may yield possible health benefits for chronic disease that deserve further study.
Understanding and Targeting the Endocannabinoid System with Activity‐Based Protein Profiling
Authors: Zhu Na , Janssen Antonius P. A. , van der Stelt Mario 
Published: February 2023

AbstractThe endocannabinoid system (ECS) is a widespread modulatory system composed of cannabinoid receptors, endogenous signaling lipids termed endocannabinoids and the enzymes for the biosynthesis and degradation of these endocannabinoids. It plays a crucial role in diverse (patho)physiological functions, such as neurotransmission, neural development, synaptic plasticity, mood, food intake, and inflammation. Enzymes involved in the biosynthesis (e. g. NAPE‐PLD, DAGLs) and degradation (e. g. FAAH, MAGL) of endocannabinoids have attracted attention from both academia and industry due to their therapeutic potential. The discovery of selective inhibitors for these enzymes is important for functional assignment and biomedical applications. Activity‐based protein profiling (ABPP) has emerged as a powerful technique, which to a large extend accelerated the development of selective inhibitors for ECS enzymes. This review summarizes the representative activity‐based probes (ABPs) and small molecular inhibitors developed in the past two decades for ECS enzymes and will discuss the biological discoveries attributed by the application of these small molecules.
AdvanCE, a capsule endoscope delivery device, is effective in investigating a waterfall stomach
Authors: Miyaguchi Kazuya , Tsuzuki Yoshikazu , Imaeda Hiroyuki 
Published: February 2023

AbstractAdvanCE is a useful device in patients who cannot swallow capsule endoscopes, or when these remain in the patient's stomach without passing into the duodenum. A net or snare may be used to guide the capsule endoscope into the duodenum when the capsule endoscope becomes stuck in the stomach, but it may be difficult to guide the capsule into the duodenum in some cases, particularly in those of waterfall stomach. In such cases, AdvanCE is found to be an effective guidance tool.
Influence of cropland on resource selection by pronghorn
Authors: Opatz Anthony P. , Fulbright Timothy E. , Mizer Gary , DeYoung Randy W. , Conway Warren C. , Gray Shawn S. , Hewitt David G. 
Published: February 2023

AbstractPronghorn (Antilocapra americana) are a grassland specialist that have experienced a >60% reduction in their historical range due to habitat fragmentation and encroachment of woody vegetation. Pronghorn populations are increasing in the Texas Panhandle despite conversion of grassland to cropland (27–43% of the regional landscape) and associated fragmentation. We hypothesized that pronghorn avoid cropland when selecting seasonal home ranges and avoid cropland within their home ranges. We captured 64 adult pronghorn of equal sex ratios in both the High Plains (n = 32) and Rolling Plains (n = 32) ecoregions of Texas, USA, during February 2017 and fitted them with iridium satellite global positioning system (GPS) collars. We collared 27 additional pronghorn in 2018 to account for mortalities and collar failures. We estimated resource selection functions for the High Plains and Rolling Plains populations using mixed‐effects logistic regression at the home range (second order) and within home range (third order) scales separately for each ecoregion and season (fawning, summer, rut, and winter). Our hypothesis that pronghorn avoid cropland was supported in the Rolling Plains ecoregion at the home range scale; otherwise, cropland was inconsistently and seasonally important in resource selection. Furthermore, pronghorn often avoided paved roads more strongly than cropland. At the home range scale during 2017–2019, female pronghorn in the High Plains selected cropland during rut and winter. Males exhibited weak selection for cropland during rut. Within home ranges in the High Plains, female pronghorn avoided cropland during fawning in 2017, during rut in 2017 and 2018, and during winter 2019 but selected areas closer to cropland in winter 2017 and fawning 2018. Males selected areas farther from cropland during all sampling dates in 2017 and winter 2019. Avoidance and selection of cropland within home ranges also varied among seasons and years in the Rolling Plains. Overall, pronghorn avoided cropland when selecting home ranges in the Rolling Plains and cropland was otherwise inconsistently and only seasonally important in resource selection at the home range and within home range scales. We speculate that loss of pronghorn habitat to cropland in the High Plains and Rolling Plains of Texas may outweigh temporary nutritional benefits from seasonal use of crops.
Ultrasonic Pin Placement for Resorbable Rigid Fixation of a Thyroid Cartilage Fracture
Authors: Gutierrez Claudia , Zaninovich Andrew , Vozzo Rebecca , Daniero James 
Published: February 2023

ObjectiveTo present the first use of an ultrasonic pin resorbable plate fixation system for rigid fixation of a laryngeal fracture.MethodsPresentation of a 20‐year‐old male with a high velocity injury to his neck, via a lacrosse ball, resulting in a displaced laryngeal cartilage fracture.ResultsIntraoperatively, a Poly‐D, L‐Lactic Acid (PDLLA) polymer plate was contoured in‐situ, bridging the fracture, and secured with ultrasonically placed resorbable pins. He was extubated on post‐op day one and had return to vocal baseline one‐month post‐op.ConclusionUltrasonic pin placement systems for resorbable rigid fixation of a thyroid cartilage fracture optimizes recovery of respiratory and phonatory functions. Laryngoscope, 133:1470–1472, 2023
Investigation of potential gender bias in the peer review system at Reproduction
Authors: Biolková Marie , Moore Tom , Schindler Karen , Swann Karl , Vail Andy , Flook Lindsay , Dick Helen , Fitzharris Greg , Price Christopher A. , Spears Norah 
Published: February 2023

AbstractThis study examined whether publication outcome was affected by the gender of author, handling associate editor (AE), or reviewer, and whether there was gender bias in reviewer selection, in the journal Reproduction. Analyses were carried out on 4289 original research manuscripts submitted to the journal between 2007 and 2019. Both female and male AEs appointed more male reviewers than female reviewers, but female AEs were significantly more likely to appoint female reviewers than male AEs were (p < 0.001). When examining the gender of either first or last author manuscripts, those with female authors that were reviewed by female reviewers received better scores than those with male authors that were reviewed by female reviewers (p < 0.05): where the reviewer was male, no such effect was observed. Acceptance rates of manuscripts were similar for both female and male authors, whether first or last, regardless of AE gender. Overall, there was no significant correlation between gender of first or last author, or of AE, on the likelihood of acceptance of a research paper. These data suggest no bias against female authors during the peer review process in this reproductive biology journal.
Large‐Area X‐Ray Scintillator Screen Based on Cesium Hafnium Chloride Microcrystals Films with High Sensitivity and Stability
Authors: Zhang Fei , Zhou Yingchun , Chen Zhipeng , Niu Xiaowei , Wang Heyong , Jia Mochen , Xiao Jiawen , Chen Xu , Wu Di , Li Xinjian , Shi Zhifeng , Shan Chongxin 
Published: February 2023

AbstractLead‐halide perovskites have received extensive attention in X‐ray imaging applications recently. However, their poor stability, lead toxicity, and strong light self‐absorption seriously limit the commercial development. Here, we report a vacancy‐ordered Cs2HfCl6 double perovskite for scintillators applications. The Cs2HfCl6 microcrystals (MCs) are characterized by broadband blue emission with a large Stokes shift. Joined experimental‐theoretical characterizations reveal the highly localized charge distribution in Cs2HfCl6 and structural distortion of [HfCl6]2− octahedron in the excited state favor the formation of self‐trapped excitons (STEs), which contribute to the broadband emission. Benefiting from the radioluminescence of STEs with negligible self‐absorption, the light yield of Cs2HfCl6 scintillator reaches 21700 photons/MeV, and the detection limit is 55 nGyair s−1. Additionally, the Cs2HfCl6 scintillator exhibits extremely low hygroscopicity and good resistance to X‐ray irradiation. Further, a large‐area scintillator screen (20×20 cm2) is fabricated by combining scrape‐coating and soft‐pressing techniques, showing a spatial resolution of 11.2 lp mm−1. Given the high spatial resolution and fast light decay of this scintillator screen, static X‐ray imaging of bulky objects is realized, and dynamic X‐ray imaging of a rotating chopping fan is demonstrated without ghosting effects. These results demonstrate the great commercial promise of Cs2HfCl6 scintillation screens for indirect X‐ray detection.
A stability and numerical study of the solutions of a Timoshenko system with distributed delay
Authors: Nonato Carlos A. , Santos Manoel J. Dos , Avila Jorge A. J. , Raposo Carlos A. 
Published: February 2023

AbstractIn this work, we analyze the stability of the semigroup associated with a Timoshenko beam model with distributed delay in the rotation angle equation. We show that the type of stability resulting from the semigroup is directly related to some model coefficients, which constitute the velocities of the system's component equations. In the case of stability of the polynomial type, we prove that rate obtained is optimal. We conclude the work performing a numerical study of the solutions and their energies, associated to discrete system.
Cd2+ and Zn2+ Complexes with 2,4,6‐Tri(2‐pyridyl)‐s‐Triazine and Terephthalate for Rapid, High‐Capacity Adsorption of Congo Red
Authors: Zhao Yanfang , Zhao Yongliang , Guo Ziyang , Zhou Dan , Yuan Shuai , Zhang Xueqiong , Chu Haibin 
Published: February 2023

AbstractThree crystal complexes were designed and synthesised through the solvothermal method, with Cu2+, Zn2+, and Cd2+ ions as the metal centres and 2,4,6‐tri(2‐pyridyl)‐s‐triazine (TPTZ) and terephthalate (BDC2−) as the ligands. Their compositions were determined to be Cd(TPTZ)Cl2 (Cd‐MOF), {[Zn(TPTZ)(BDC)] ⋅ 3H2O}n (Zn‐MOF), and Cu2(PCA)2(BDC)(H2O)2 (Cu‐MOF) (PCA−=2‐pyridinium amide), respectively. Cd‐MOF can adsorb 90 % of Congo red (CR) in 10 s at room temperature and atmospheric pressure, and CR removal was complete at 20 s over a wide pH range. The adsorption capacity for CR reached 1440 mg g−1 in 5 min. Selective adsorption was demonstrated in mixed dyes. The adsorption kinetic data agree well with the pseudo‐second‐order kinetic model. The Temkin model was successfully used to evaluate the adsorption isotherms of CR on Cd‐MOF at room temperature, suggesting that adsorption occurs through a hybrid of monolayer and multilayer mechanisms.
The COVID Cash Transfer Study: The Impacts of a One‐Time Unconditional Cash Transfer on the Well‐Being of Families Receiving SNAP in Twelve States
Authors: Pilkauskas Natasha V. , Jacob Brian A. , Rhodes Elizabeth , Richard Katherine , Shaefer H. Luke 
Published: February 2023

AbstractThere is growing interest in the use of unconditional cash transfers as a means to alleviate poverty, yet little is known about the effects of such transfers in the U.S. This paper reports on the results of a randomized controlled study of a one‐time $1,000 unconditional cash transfer in May 2020 to families with low incomes in 12 U.S. states. The families were receiving, or had recently received, Supplemental Nutrition Assistance Program benefits. We examine the impact of the cash transfer on five pre‐registered outcomes (material hardship, mental health, parenting, child behavior, partner relationships) and several secondary outcomes (hardship avoidance, consumption, employment, benefit use). We find no statistically significant effects (powered to detect effects of 0.09 standard deviations) of the cash transfer on any outcomes for the full sample. In pre‐specified exploratory analyses, we find significant reductions in material hardship (‐0.17 standard deviations) among families with less than $500 of earnings in the previous month, roughly the bottom 50 percent of monthly earnings for the study sample.