bluuebunny/crossref_metadata_2025_split huggingface dataset:
LMLPA: Language Model Linguistic Personality Assessment
Authors: Zheng Jingyao , Wang Xian , Hosio Simo , Xu Xiaoxian , Lee Lik-Hang 
Published: January 2025

Abstract
Large Language Models (LLMs) are increasingly used in everyday life and research. One of the most common use cases is conversational interactions, enabled by the language generation capabilities of LLMs. Just as between two humans, a conversation between an LLM-powered entity and a human depends on the personality of the conversants. However, measuring the personality of a given LLM is currently a challenge. This article introduces the Language Model Linguistic Personality Assessment (LMLPA), a system designed to evaluate the linguistic personalities of LLMs. Our system helps to understand LLMs’ language generation capabilities by quantitatively assessing the distinct personality traits reflected in their linguistic outputs. Unlike traditional human-centric psychometrics, the LMLPA adapts a personality assessment questionnaire, specifically the Big Five Inventory, to align with the operational capabilities of LLMs, and also incorporates the findings from previous language-based personality measurement literature.
Return to On-Snow Performance in Ski Racing After Anterior Cruciate Ligament Reconstruction
Authors: Morris Nathaniel , da Silva Torres Ricardo , Heard Mark , Doyle Baker Patricia , Herzog Walter , Jordan Matthew J. 
Published: January 2025

Background: The individual variation in on-snow performance outcomes after anterior cruciate ligament (ACL) reconstruction (ACLR) in elite alpine ski racers has not been reported and may be influenced by specific injury characteristics. Purpose: To report the performance statistics of elite ski racers before and after ACLR and to identify surgical and athlete-specific factors that may be associated with performance recovery. Study Design: Descriptive epidemiological study. Methods: International Ski and Snowboard Federation (FIS) points, FIS ranking, average placing, and average percentage behind the winning time in each race were calculated for 30 national and provincial team ski racers at 1 year before and 3 years after ACLR. Injury characteristics were obtained from operative reports and clinical notes. Results: The mean age at the time of primary ACLR was 21.6 ± 3.5 years. Overall, 27 of 30 (90%) ski racers returned to the same preinjury competition level. Yet, only 16 of 30 (53%) improved in FIS points, and 13 of 30 (43%) improved in FIS ranking, in one of the speed or technical disciplines by 3 years after surgery. Of the skiers who improved in FIS points, 36% sustained multiligamentous injuries, 45% sustained meniscal tears, and 45% sustained chondral lesions. Of those who failed to improve in FIS points, 50% sustained multiligamentous injuries, 50% sustained meniscal tears, and 60% sustained chondral lesions. Meniscal tears and chondral lesions occurred mostly on the lateral side. The medial collateral ligament was involved in 8 of 9 multiligamentous injuries. Conclusion: These findings suggest significant individual variation in the recovery of on-snow performance of ski racers after ACLR, despite returning to the same competition circuit. The pattern of secondary injuries alongside primary ACL ruptures showed little association with improved performance.
Fuelling Electric Vehicles Growth: Factors that Matter in India’s Electric Vehicles Growth Story
Authors: Rajmal  , Gupta Kirti 
Published: January 2025

The recent impetus to the electric vehicle (EV) policies at the national and sub-national levels with the medium to long-term objective of reducing greenhouse gas emissions from vehicle traffic motivates an assessment of the key drivers of EVs in India. The sale of EVs especially two-wheelers is rising due to the push by government policies, reduction in upfront costs and increased awareness about EVs. However, the sale of electric cars has not picked up significantly and is uneven across states. The study finds a strong correlation between the use of electric cars in states and the availability of public charging stations. The empirical analysis finds that the availability of public charging infrastructure and the price differentials between electric cars and comparable internal combustion engine cars are significantly associated with the demand for cars across states. A focused and liberal policy assumes importance to stimulate the demand for EVs and to harness its manifold environmental and financial gains. JEL Classifications: Q42, Q48, Q49
Association Between Rotator Cuff Tears and Shoulder MRI Parameters: Importance of Arthroscopic Validation in Coronal Acromiohumeral Interval Measurement
Authors: Ilyas Gokhan , Ipci Fikri Burak , Egeli Ercument , Kalenderer Onder 
Published: January 2025

Background: Magnetic resonance imaging (MRI) measurement parameters—the standard noninvasive diagnostic method for rotator cuff tears (RCTs)—have been used to compare groups with and without RCTs. Arthroscopy is used in definitive diagnosis and treatment. Purposes: To evaluate the association between RCT and shoulder angles and distances on MRI in patients with and without arthroscopically validated RCT and to determine whether the degree of rotator cuff fatty degeneration affects the MRI measurements. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Shoulder measurements on MRI were compared between patients with and without RCT as confirmed by shoulder arthroscopy performed by a single surgeon between 2019 and 2024, and non-RCT patients without arthroscopic confirmation. Interobserver reliability (Fleiss kappa coefficient) was calculated for the measurements. The groups were compared using the independent t test or the Mann-Whitney U test. The RCT group was further divided according to the level of fatty degeneration (Goutallier types 0-1-2 vs types 3-4) for subanalysis. Results: In addition to the 368 RCT and 55 non-RCT patients with arthroscopic confirmation, there were 92 non-RCT patients without arthroscopic confirmation. The sagittal acromiohumeral interval (AHI) (8.32 vs 9.24 mm), coronal AHI (7.87 vs 8.96 mm), and coronal AHI/glenoid height ratio (22.63% vs 24.88%) were significantly lower in the patients with RCT ( P < .001, P < .001, and P = .001, respectively). In contrast, the critical shoulder angle (CSA) (33.17° vs 31.92°) and the glenoid width/humeral head coverage ratio (57.52% vs 55.7%) were significantly higher in the patients with RCT ( P = .037 and P = .017, respectively). Higher rotator cuff fatty degeneration levels (Goutallier types 3-4) further increased these differences within the patients with RCT ( P < .001 for all). When the arthroscopically validated and nonvalidated non-RCT patients were compared, coronal AHI and AHI/glenoid height ratio values were found to be significantly lower in the nonvalidated group ( P = .034 and P = .047, respectively). Conclusion: In this study, RCT was associated with decreased sagittal AHI, coronal AHI, and coronal AHI/glenoid height ratios and increased CSA and glenoid width/humeral head coverage ratios.
Unveiling cell-type-specific microRNA networks through alternative polyadenylation in glioblastoma
Authors: Cihan Mert , Schmauck Greta , Sprang Maximilian , Andrade-Navarro Miguel A. 
Published: January 2025

Abstract

Background
Glioblastoma multiforme (GBM) is characterized by its cellular complexity, with a microenvironment consisting of diverse cell types, including oligodendrocyte precursor cells (OPCs) and neoplastic CD133 + radial glia-like cells. This study focuses on exploring the distinct cellular transitions in GBM, emphasizing the role of alternative polyadenylation (APA) in modulating microRNA-binding and post-transcriptional regulation.

Results
Our research identified unique APA profiles that signify the transitional phases between neoplastic cells and OPCs, underscoring the importance of APA in cellular identity and transformation in GBM. A significant finding was the disconnection between differential APA events and gene expression alterations, indicating that APA operates as an independent regulatory mechanism. We also highlighted the specific genes in neoplastic cells and OPCs that lose microRNA-binding sites due to APA, which are crucial for maintaining stem cell characteristics and DNA repair, respectively. The constructed networks of microRNA-transcription factor-target genes provide insights into the cellular mechanisms influencing cancer cell survival and therapeutic resistance.

Conclusions
This study elucidates the APA-driven regulatory framework within GBM, spotlighting its influence on cell state transitions and microRNA network dynamics. Our comprehensive analysis using single-cell RNA sequencing data to investigate the microRNA-binding sites altered by APA profiles offers a robust foundation for future research, presenting a novel approach to understanding and potentially targeting the complex molecular interplay in GBM.
Lessons from the pandemic: Relationship between patient visits and patient length of stay in California’s health system
Authors: Cho David D. , Wang Yu 
Published: January 2025

Abstract

Background
The coronavirus disease 2019 (COVID-19) pandemic placed a heavy strain on the United States healthcare system. Common hospital operational performances were impacted to varying degrees by the pandemic. This study examined the healthcare operational measures during COVID-19 pandemic.

Methods
This cross-sectional study examined the COVID-19 cases and death counts of 56 California counties and hospital-level utilization data of 397 hospitals in California from January 2019 to March 2021.

Results
A total of 56 California counties were analysed, of which 37 counties were urban and 19 counties were rural. Average patient length of stay was positively associated with the number of intensive care unit visits by COVID-19 patients for all counties, as well as urban and rural counties separately. However, average patient length of stay was negatively associated with the number of inpatient visits by COVID-19 patients for all counties and urban counties.

Conclusions
The findings suggest that, while the need for additional beds and nursing staff in intensive care units exceeded initial estimates, there were also opportunities to streamline the care process for improved efficiency in regular acute care units. The understanding of factors impacting average patient length of stay would be valuable for hospital administrators in optimizing resource allocation and utilization to balance patient outcomes with financial sustainability during disruptive events.
A comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment?
Authors: Mohr Isabelle , Lamade Patrick , Weber Christophe , Leidner Viola , Köhrer Sebastian , Olkus Alexander , Lang Matthias , Langel Andrea , Dankert Patrischia , Greibich Melanie , Wolf Silke , Zimmer Holger , Michl Patrick , Poujois Aurélia , Weiss Karl Heinz , Merle Uta 
Published: January 2025

Abstract

Background & Aim
Twenty-four-hour urinary copper excretion (24 h-UCE) is the standard diagnostic tool for dose adjustments in maintenance therapy in Wilson disease (WD) patients. Guidelines lack data if both variants of 24 h-UCE measurement (with or without 48 h of treatment interruption) are equally interpretable.

Methods
Eighty-four patients with a confirmed diagnosis of WD treated with chelators (50% of patients with D-Penicillamine and 50% with trientine) and with pairwise 24-h-UCE values on-therapy and off-therapy were included in the analysis. Pairwise urinary sampling between October 2022 (T0) and a 12-month FU (T2) was compared, and exchangeable copper (CuEXC) was additionally measured at T0.

Results
Among the 84 patients, 65% had predominant hepatic symptoms, the median age was 42 years, and 58% were female. At T0, patients were in the stable maintenance phase, with a median treatment duration of 21.9 years. The levels of the biochemical markers liver and copper metabolism remained stable over the 12-month observation period for all patients. 24 h-UCE off-therapy significantly decreased from T0 to T2 (p = 0.03), whereas no statistically significant differences were detected for 24 h-UCE after therapy. Both sampling methods did not correlate. CuEXC was significantly correlated with 24 h-UCE after 48 h of dose interruption (p = 0.018) but not with 24 h-UCE after therapy. A total of 46% of the 24 h-UCE value pairs were discordant, laying out the aimed therapeutic ranges given in current international guidelines.

Conclusion
Off-therapy 24 h-UCE reflects the “free” copper pool more accurately than does urinary sampling. The study shows discordant results for both sampling methods in approximately half of the patients, revealing that interpretation of 24 h-UCE with respect to chelator-dosing decisions should be performed with caution.
Identification of novel RIPK4 variants in a Chinese patient with Arthrogryposis Multiplex Congenita (AMC)
Authors: Lu Yi-Lei , Liu Meng-wei , Jin Jie-Yuan , Pan Ding 
Published: January 2025

Abstract

Background
Arthrogryposis multiplex congenita (AMC) is a congenital disorder characterized by multiple joint involvement, primarily affecting limb mobility and leading to various tissue contractures. Variations in the RIPK4 gene may impact connective tissues, thereby resulting in a spectrum of malformations. This study aimed to identify the genetic etiologies of AMC patients and provide genetic testing information for further diagnosis and treatment of AMC.

Methods
We recruited a Chinese female patient with hand-related AMC and her family members. Whole-exome sequencing (WES) was employed to determine the genetic etiologies of the patient’s disease. The pathogenic mechanisms of the identified variations were analyzed using protein tolerance profiling and modeling.

Results
We identified two novel RIPK4 variants (c.1354G > A, p.E452K; c.1558A > T, p.T520S). Pathogenicity studies indicated that the c.1354G > A, p.E452K variant changed the charge from negative to positive and altered the chemical properties from acidic to alkaline, potentially significantly affecting protein function.

Conclusions
We reported the discovery of two novel RIPK4 variants (c.1354G > A, p.E452K; c.1558A > T, p.T520S) in a Chinese AMC female patient’s family. Our study enhances the genetic repository for AMC and highlights the pathogenicity of RIPK4 variants, underscoring the significance of comprehensive management for genetic-related diseases, particularly the critical roles of prenatal diagnosis and genetic counseling.

Trial registration
The research protocol received approval from the Ethics Review Committee of Xiangya Hospital of Central South University in China (approval number: 202103427), registered in March 2021, with all participants providing duly signed informed consent forms.
A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease
Authors: Scutari Rossana , Linardos Giulia , Ranno Stefania , Pisani Mara , Vittucci Anna Chiara , Coltella Luana , Colagrossi Luna , Di Maio Velia Chiara , Sisto Annamaria , Mancinelli Livia , Landi Simona , Cristaldi Sebastian , Raponi Massimiliano , Bernaschi Paola , Villani Alberto , Russo Cristina , Perno Carlo Federico 
Published: January 2025

Abstract

Background
In recent months, Bordetella pertussis has reappeared after maintaining a low rate for many years. Although pertussis is usually characterized by a favorable course, several factors can contribute to the severity of the disease, such as mixed respiratory infections. In this study, we evaluate B.pertussis cases observed in the pediatric population followed at the Bambino Gesù Children's Hospital and analyzed the potential impact of co-infections in relation to disease severity.

Methods
From January to May 2024, a total of 1,151 children and adolescents (both inpatients and outpatients) were screened for the presence of respiratory pathogens, including B.pertussis, with clinically relevant respiratory symptoms.

Results
Among the 1,151 patients screened, 66 tested positive for B.pertussis. Fourteen patients had respiratory failure, and six of them required intensive care unit (ICU) admission, while 52 had mild infection. 23.3% of patients had B.pertussis alone, while 76.7% had co-infections (including 5 patients admitted to the ICU). A higher co-infection rate was observed in patients with respiratory failure than in those without failure (92.9% vs. 69.0%, p-value:0.041). Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure.

Conclusions
Our results highlighted an increase in B.pertussis cases from January to May 2024, reaching a peak of cases in the month of May. This study shows a high rate of B.pertussis co-infection, and a trend toward association between B.pertussis and specific viruses, that might play a role in increasing disease severity.
Prehospital lactate analysis in suspected sepsis improves detection of patients with increased mortality risk: an observational study
Authors: Andersson Maria , Fröderberg Schooner Karin , Karlsson Werther Viktor , Karlsson Thomas , De Geer Lina , Wilhelms Daniel B. , Holmbom Martin , Fredrikson Mats , Östholm Åse , Berg Sören , Hanberger Håkan 
Published: January 2025

Abstract

Background
Rapid, adequate treatment is crucial to reduce mortality in sepsis. Risk stratification scores used at emergency departments (ED) are limited in detecting all septic patients with increased mortality risk. We assessed whether the addition of prehospital lactate analysis to clinical risk stratification tools improves detection of patients with increased risk for rapid deterioration and death in sepsis.

Methods
A10-month observational study with consecutive, prospective prehospital inclusion of adult patients with suspected sepsis. Prehospital lactate was used as a continuous variable and in intervals. Analyses of patient subgroups with high and lower priorities according to Rapid Emergency Triage and Treatment System (RETTS) and National Early Warning Score 2 (NEWS2) were performed. Primary outcome was 30-day mortality, secondary outcomes were sepsis at the ED and in-hospital mortality.

Results
In all, 714 patients were included with a 30-day mortality of 10%. Among the 322 cases (45%) fulfilling Sepsis-3 criteria, the 30-day mortality was 14%. Prehospital lactate was higher among non-survivors (2.6 vs 2.0 mmol/L, p < 0.001). Mortality at different lactate intervals were: 6.7%, at 0–2 mmol/l; 10.0% at > 2–3 mmol/l; 19.2% at > 3–4 mmol/l; and 17.0% at levels > 4 mmol/l. The highest RETTS priority (red) group had higher lactate levels than the lower (non-red) priority group (2.5 vs 1.9 mmol/L, p < 0.001). In the non-red group, prehospital lactate was higher among non-survivors (2.4 vs 1.8 mmol/L, p = 0.002). In the multivariable regression analysis, prehospital lactate > 3 mmol/l was a predictor of 30-day mortality (OR 2.20, p = 0.009) This association was even stronger in the lower priority RETTS non-red group (OR 3.02, p = 0.009). Adding prehospital lactate > 3 mmol/l increased identification of non-survivors from 48 to 68% in the RETTS red group and from 77 to 85% for the NEWS2 ≥ 7 group.

Conclusion
The addition of a prehospital lactate level > 3 mmol/l improved early recognition of individuals with increased mortality risk in a cohort with suspected sepsis admitted to the ED. This was particularly evident in patients whose risk stratification scores did not indicate severe illness. We suggest that the addition of prehospital lactate analysis could improve recognition of subjects with suspected sepsis and increased mortality risk.

Graphical Abstract
Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease
Authors: Ou Kaili , Jia Qingqing , Li Dandan , Li Shihua , Li Xiao-Jiang , Yin Peng 
Published: January 2025

Abstract
Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches have been developed based on the genetic causes and potential mechanisms of ALS and HD. Currently, available treatments for various neurodegenerative diseases can alleviate symptoms but do not provide a definitive cure. Gene therapy, which aims to modify or express specific proteins for neuroprotection or correction, is considered a powerful tool in managing neurodegenerative conditions. To date, antisense oligonucleotide (ASO) drugs targeting the pathological genes associated with ALS and HD have shown promising results in numerous animal studies and several clinical trials. This review provides a comprehensive overview of the development, mechanisms of action, limitations, and clinical applications of ASO drugs in neurodegenerative diseases, with a specific focus on ALS and HD therapeutic strategies.
Spatiotemporal variation of high-temperature events and its relation to coral bleaching in the Ryukyu Islands, Japan
Authors: Yasunaka Sayaka , Kurihara Haruko , Doi Takeshi 
Published: January 2025

Abstract
Coral bleaching occurs when symbiotic dinoflagellate algae leave corals due to warming surface waters. Since the early 1980s, the number and intensity of coral bleaching events have significantly risen globally, and many coral reefs are concerned to undergo irreversible phase shifts due to global warming. In this study, we examine spatiotemporal variations and relationships of high-temperature events, high-temperature anomaly events, and coral bleaching around the Ryukyu Islands, Japan. We also explore the correlation between these occurrences and the large-scale climate variability, El Niño–Southern Oscillation and Indian Ocean Dipole. More than 99% of the high-temperature events occurred from June to October, and more than 80% occurred from July to September, whereas high-temperature anomaly events occurred all year round. Corresponding with high-temperature events, more than 10% of the data reported overall bleaching, and more than 25% reported partial bleaching from June to October. Over 40% of data reported bleaching in August, of which 50% of these reports were categorized as overall bleaching and the remainder as partial. The spatial distribution of coral bleaching also corresponded better with high-temperature events than high-temperature anomaly events. In 2016, extensive and severe coral bleaching was reported around the Okinawa, Miyako, and Yaeyama Islands, where intense high-temperature events had occurred. The central-to-eastern equatorial Pacific displayed a negative sea surface temperature anomaly, and the eastern Indian Ocean did a positive anomaly following high-temperature events near the Ryukyu Islands. These findings indicated that the high-temperature events around the Ryukyu Islands show correlation with La Niña and a negative Indian Ocean Dipole. If the cumulative temperature of high-temperature events exceeds 56 °C-days every three years in the late 2030s, then the corals around the Ryukyu Islands will suffer high mortality within 20 years.