bluuebunny/crossref_metadata_2025_split huggingface dataset:
EKSPLORASI PENGALAMAN PERAWAT TERHADAP STIGMATISASI SELAMA PANDEMI COVID-19
Authors: Siahaan Mindo Kristofani Elizabeth , Kadar Kusrini S , Sjattar Elly Lilianty 
Published: January 2023

Pendahuluan : Meningkatnya kasus dan kematian selama pandemic COVID-19, menyebabkan petugas kesehatan sebagai garda terdepan memperoleh berbagai tekanan sosial termasuk isolasi , stigma dan diskriminasi maupun masalah psikologis lainnya. Tidak jarang petugas kesehatan seringkali diberi label, ditetapkan sebagai bagian yang terpapar dan menghadapi kehilangan status dan diskriminasi karena stigma terkait dengan COVID-19. Tujuan: untuk menggali pengalaman perawat terhadap stigmatisasi selama pandemic COVID-19. Metode: Penelitian ini menggunakan metode kualitatif dengan pendekatan eksplorasi deskriptif kualitatif. Hasil: Terdapat 6 tema yang didapatkan: Penyebab terjadinya stigmatisasi; Sumber stigmatisasi terhadap perawat; Bentuk stigmatisasi yang dialami perawat; Respon perawat terhadap stigmatisasi yang dirasakan; Mekanisme koping yang digunakan perawat; dan Dukungan sosial bagi perawat dalam menghadapi stigmatisasi. Kesimpulan: Mayoritas perawat mengungkapkan bahwa stigmatisasi yang mereka alami disebabkan karena kurangnya pengetahuan, tingginya resiko penularan, dan informasi yang kurang tepat atau hoax yang diterima oleh keluarga maupun masyarakat. Untuk mengatasi stigmatisasi penting untuk menciptakan lingkungan yang kondusif dengan melakukan pendidikan kesehatan dan diskusi terbuka antara masyarakat dengan petugas kesehatan tentang Covid-19 untuk mendukung mereka mengambil tindakan yang efektif dalam memerangi penyakit, mengurangi ketakutan dan stigma.
EFEKTIFITAS PENGGUNAAN MEDIA LEAFLET DALAM PENINGKATAN PENGETAHUAN DAN SIKAP TERHADAP PENCEGAHAN TUBERKULOSIS
Authors: Pratiwi Gilang Dwi , Vita Lucya  , Paramitha  
Published: January 2023

Pendahuluan: Fakta bahwa tuberkulosis (TB) terus menjadi ancaman kesehatan, diperlukan tindakan dalam percepatan mengakhiri Tuberkulosis, salah satunya dengan strategi promosi kesehatan. Media leaflet sebagai sarana yang sederhana dan mudah dibawa, masih menjadi pilihan dalam promosi kesehatan. Tujuan: untuk mengetahui efektifitas media leaflet dalam peningkatan pengetahuan dan sikap terhadap pencegahan TB di Puskesmas Garuda Bandung. Metode: Sebanyak 60 responden dibagi kedalam kelompok kontrol dan perlakuan. Pengambilan informasi mengenai pengetahuan dan sikap responden terhadap pencegahan TB, dilakukan pada awal penelitian dan 2 minggu setelah diberikan perlakuan. Data dianalisis menggunakan t-test dan ANCOVA. Hasil: sebagian besar responden berada pada kelompok usia 33-40 tahun, berjenis kelamin perempuan, dengan tingkat Pendidikan terakhir SMA dan bekerja di bidang infomal. Pengetahuan dan sikap responden sebelum perlakuan menunjukkan perbedaan yang bermakna diantara kedua kelompok (p<0.05). Analisis bivariat pada kelompok perlakuan menunjukkan hasil yang signifikan antara pre dan post-test, baik pada aspek pengetahuan (p<0.05) maupun sikap (p<0.05). Pada analisis kovarians, didapatkan bahwa perlakuan menunjukkan pengaruh yang signifikan terhadap pengetahuan (p<0.05) maupun sikap (p<0.05). Kesimpulan:Media leaflet efektif sebagai metode untuk meningkatkan pengetahuan dan sikap masyarakat terhadap pencegahan tuberculosis. Diperlukan studi lebih lanjut untuk menjelaskan resistensi dari pengetahuan dan sikap.
PENGARUH PEMBERIAN EKSTRAK IKAN GABUS (CHANNA STARATA) TERHADAP LUKA PERINIUM DI WILAYAH KERJA PUSKEMAS WALANTAKA KOTA SERANG
Authors: Rositah  , Ita Herawati  
Published: January 2023

Pendahuluan: Secara fisiologis luka perineum akan mulai membaik dalam jangka waktu 6 sampai 7 hari postpartum. Berdasarkan data yang diperoleh dari Puskesmas Walantaka Kota Serang untuk penyembuhan luka perinium masih menggunakan jenis terapi farmakologi yaitu penggunaan seperti analgesik dan antibiotik. Berdasarkan data yang diperoleh bahwa masih lamanya proses penyembuhan luka perineum pada ibu nifas dan rendahnya pengetahuan ibu tentang penyembuhan luka perineum yang lebih cepat selain dengan konsumsi terapi farmakologi.Tujuan: Untuk mengetahui Pengaruh pemberian ekstrak ikan gabus (channa starata) terhadap luka perinium di wilayah kerja Puskemas Walantaka Kota Serang. Metode: Penelitian quasy experimental design ini menggunakan pendekatan one group pretest-postest design. Sampel dikumpulkan menggunakan quota sampling berjumlah 40 orang ibu postpartum. Lembar observasi yang digunakan untuk mengukur penyembuhan luka perineum pada kelompok intervensi dan kontrol. Hasil: Rata-rata penyembuhan luka perineum antara kelompok intervensi (3,65) dan kontrol (5,50) pada ibu di wilayah kerja Puskemas Walantaka Kota Serang. Simpulan dan Saran: Ada pengaruh pemberian ekstrak ikan gabus (channa starata) terhadap luka perinium dengn hasil (p.value 0,000). Diharapkan penelitian ini dapat memberikan informasi khususnya dibidang ilmu kebidanan pada masa nifas terhadap asuhan kebidanan tentang fungsi, kegunaan dan manfaat ekstrak ikan gabus (channa starata) sehingga dapat mencegah terjadinya infeksi perinium dan membantu proses penyembuhan luka perineum.
Pelatihan Pembuatan MP-ASI Berbahan Ubi Jalar Kuning dan Ikan Oci kepada Ibu Balita di Posyandu Kumudagu
Authors: Sriyanti Sriyanti , Sada Merinta , Kamaruddin Mustamir 
Published: January 2023

The malnutrition among children under five in West Papua was still high, at about 26,2%. This condition was related to nutritional intake that was not optimal. This PkM aims to increase the knowledge of the posyandu cadre and mothers of children in processing local foodstuffs of yellow potato and oci fish into various MP-ASI. This PkM was carried out with two visits targeting cadres and mothers of toddlers. The methods used were counseling about PMBA, demonstration, and training on the manufacture of MP-ASI made from yellow sweet potato and oci fish, testing the level of preference for MP-ASI products, and evaluating knowledge using a questionnaire. The results of the PkM show an increase in the knowledge of kader and mothers of toddlers about PMBA, which is indicated by the level of knowledge of most participants before being given counseling in the less category as much as 62.5% and after being given counseling most of them have a sufficient level of knowledge (68.7%). The level of preference of participants for the biscuit products of yellow sweet potato flour and oci fish meal as a whole showed an average of 4.06, which was included in the liking scale.
Application of MIA-QSAR in Designing New Protein P38 MAP Kinase Compounds Using a Genetic Algorithm
Authors: Mirshafiei Mithra , Niazi Ali , Yazdanipour Ateesa 
Published: January 2023

Multivariate image analysis quantitative structure-activity relationship (MIA-QSAR) study aims to obtain information from a descriptor set, which are image pixels of two-dimensional molecule structures. In the QSAR study of protein P38 mitogen-activated protein (MAP) kinase compounds, the genetic algorithm application for pixel selection and image processing is investigated. There is a quantitative relationship between the structure and the pIC50 based on the information obtained. (The pIC50 is the negative logarithm of the half-maximal inhibitory concentration ( IC50 ), so pIC50 = −log IC50 .) Protein P38 MAP kinase inhibitors are used in the treatment of malignant tumors. The development of a model to predict the pIC50 of these compounds was performed in this study. To accomplish this, the molecules were first plotted and fixed in the same coordinates in ChemSketch. Then, the images were processed in the MATLAB program. Partial least squares (PLS) model, orthogonal signal correction partial least squares (OSC-PLS) model, and genetic algorithm partial least squares (GA-PLS) model methods are used to generate quantitative models, and pIC50 prediction is performed. The GA-PLS model has the highest predictive power for a series of statistical parameters such as root mean square error of prediction (RMSEP) and relative standard errors of prediction (RSEP). Finally, the molecular junction (docking) was done for predicted molecules in quantitative structure activity relationship (QSAR) with an appropriate receptor and acceptable results were obtained. These results are good and proper for the prediction of compounds with better properties.
Optimization of an analytical method for carbaryl and chlorpyrifos residues determination by LC-MS/MS
Authors: Prodhan Mohammad Dalower Hossain , Afroze Marina , Begum Afroza , Ahmed Md Sultan , Dutta Nirmal Kumar , Sarker Debasish 
Published: January 2023

The present study was aimed to optimize an analytical method for the quantification of carbamate and organophosphorus insecticide residues using Liquid Chromatography tandem Mass Spectrometry (LC-MS/MS). A series of experiments were conducted to select the parent ion and precusor ion and based on these findings, the analytical method for the determination of carbamate and organophosphorus insecticide residues using LC-MS/MS was developed. The electrospray ionization (ESI) mode was used to develop the method. The linearity of the developed analytical method was very good and it was 0.999 for carbaryl, while it was 0.998 for chlorpyrifos. The optimization of MS/MS parameters has been done properly for both of the selected pesticides through direct infusion of 100 ug/L pure analytical standard solutions.
Asian Australas. J. Biosci. Biotechnol. 2022, 7 (3), 107-113
Rancang Bangun Sistem Informasi Akuntansi Sekolah di SMK Cendika Bangsa berbasis Web
Authors: Cahyanti Nungky Dwi , Hanif Fahmi Muhammad , Anugrah Hamdhana Raka 
Published: January 2023

Sistem manual yang digunakan dalam proses pencatatan transaksi di SMK Cendika Bangsa Kepanjen ini menimbulkan banyak kendala. Kendala-kendala tersebut diantaranya yaitu terjadinya penumpukan data, kesulitan saat pengolahan dan pencarian data serta menyebabkan timbulnya kesalahan data. Oleh sebab itu, maksud dari penelitian ini yaitu untuk membangun sistem informasi akuntansi sekolah berbasis web yang menghasilkan laporan keuangan yang akurat dan transparan. Pengumpulan data yang digunakan yaitu dengan menggunakan metode wawancara, observasi dan metode kepustakaan. Sistem ini merupakan sistem berbasis web yang dibangun menggunakan bahasa pemrograman PHP dan database MySQL dengan menerapkan metode waterfall atau air terjun serta menggunakan pengjjian black-box. Sistem ini dibuat dengan beberapa tahap seperti analisis kebutuhan sistem, perancangan desain sistem, perancangan desain tampilan hingga implementasi ke dalam kode-kode program serta pengujian sistem. Sistem ini mencakup beberapa konten, diantaranya yaitu dashboard, data akun, rekening bank, data transaksi serta laporan. Hasil dari pengujian black-box disimpulkan bahwa fungsi-fungsi yang ada pada sistem ini berjalan sesuai dengan apa yang diharapkan user. Oleh sebab itu, diharapkan dengan adanya sistem informasi akuntansi sekolah ini bisa memudahkan kinerja staf keuangan dalam mencatat dan mengolah transaksi menjadi laporan keuangan di SMK Cendika Bangsa Kepanjen.
A modified method for constructing experimental rat periodontitis model
Authors: Zhang Xuyang , Xu Minglu , Xue Qin , He Yao 
Published: January 2023

Background: Periodontitis is a prevalent disease caused teeth lost. The present rat models inducing periodontitis with thread ligature and metal steel ligature have some disadvantages.Methods: We modified the existing rat ligature periodontitis model by fixing the thread ligature on the metal steel ligature passed through the gap between the first and second molars of rats with detailed modeling steps and illustrations. We research the pathological process of the periodontitis induced by the modified model, and briefly compared the modified model with the thread ligature model and the metal steel ligature model.Result: Our experimental results showed that there was an aggravation in inflammatory infiltration and alveolar bone resorption in modeling area within 14 days of initial induction. After that, the inflammatory infiltration was reduced. And no significant increase in alveolar bone destruction appeared. The modified model was more reliable compared to the thread ligature model, and had greater ability of bacterial aggregation compared to the metal steel ligature model.Conclusion: The modified method covered pathological process of the periodontitis, and showed sufficient efficiency and reliability in inducing rat periodontitis.
Prevalence and grade of diabetic peripheral neuropathy among known diabetic patients in rural Uganda
Authors: Munyambalu Dalton Kambale , Hildago Idania , Bafwa Yves Tibamwenda , Lagoro Charles Abonga , Sikakulya Franck Katembo , Vahwere Bienfait Mumbere , Dafiewhare Ephraim , Martinez Lazaro , Charles Fardous Abeya 
Published: January 2023

BackgroundDiabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus (DM). Approximately 50% of diabetic patients are estimated to develop DPN, depending on disease duration and diabetic control. Early diagnosis of DPN will avoid complications, including non-traumatic lower limb amputation, which is considered the most debilitating complication, as well as significant psychological, social, and economical problems. There is a paucity of literature on DPN from rural Uganda. This study aimed to deliver the prevalence and grade of DPN among DM patients in rural Uganda.MethodsA cross-sectional study that recruited 319 known DM patients was conducted in an outpatient clinic and a diabetic clinic at Kampala International University-Teaching Hospital (KIU-TH), Bushenyi, Uganda, between December 2019 and March 2020. Questionnaires were used to obtain clinical and sociodemographic data, a neurological examination was carried out to assess the DPN, and a blood sample was collected from each participant (for random/fasting blood glucose and glycosylated hemoglobin analyses). Data were analyzed using Stata version 15.0.ResultsThe sample size was 319 participants. The mean age of study participants was 59.4 ± 14.6 years and there were 197 (61.8%) females. The prevalence of DPN was 65.8% (210/319) (95% CI 60.4% to 70.9%), and 44.8% of participants had mild DPN, 42.4% had moderate DPN, and 12.8% had severe DPN.ConclusionThe prevalence of DPN at KIU-TH was higher among DM patients and its stage might have a negative impact on the progression of Diabetes Mellitus. Therefore, clinicians should consider neurological examination as a routine during assessment of all DM patients especially in rural areas where resources and facilities are often limited so that complications related to Diabetic mellitus will be prevented.
LL-VNS attenuates SK2 expression and incidence of arrhythmias following acute myocardial infarction in rats
Authors: Chen Mingxian , Zhu Tongjian , Wu Zhihong , Hu Lin , Wu Zhijian , Liu Qiming , Zhou Shenghua 
Published: January 2023

ObjectivesOur previous study has demonstrated that low-level vagus nerve stimulation (LL-VNS) protects the heart against ventricular arrhythmias (VAs) induced by acute myocardial infarction (AMI). However, the potential mechanisms by which it influences ventricular electrophysiology remain unknown.Materials and methodsForty-five rats were divided into three groups: a Control group (sham AMI followed by sham LL-VNS, n = 15), an AMI group (AMI followed by sham LL-VSN for 60 mins, n = 15), and an AMI + LL-VNS group (AMI followed by LL-VSN for 60 mins, n = 15). Heart rate variability (HRV), ventricular effective refractory period (ERP), ventricular fibrillation threshold (VFT), and left stellate ganglion (LSG) activity were measured at baseline and during AMI. Finally, myocardial tissues were collected for tissue analysis.ResultsAMI directly induced hyperactivity in the LSG and reduced vagal tone as indexed by HRV. AMI also decreased VFT, and shortened ERP but increased ERP dispersion. AMI resulted in an increase in expression of ventricular small-conductance Ca2+-activated K+ (SK2). However, LL-VNS significantly mitigated or eliminated the effects of AMI.ConclusionLL-VNS altered the electrophysiological properties of the ventricles through inhibition of cardiac sympathetic nervous activity and reduction in SK2 expression.
Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis
Authors: Cao Fen , Wu Kun , Zhu Yong-zhi , Jiang Jun-jun , Zhang Gui , Liu Jun , Xiao Ping , Tian Yang , Zhang Wei , Zhang Sheng , Hou Feng , Bao Zhong-wu 
Published: January 2023

BackgroundPulmonary arterial hypertension (PAH) is a fatal disease characterized by pulmonary vascular remodeling and increased pulmonary artery pressure, leading to impaired lung oxygenation, right heart failure, and even death. Although great advances have been made in PAH-targeted medications for pediatric patients, the efficacy and safety of these treatments are controversial.MethodsWe retrieved relevant articles from electronic databases including PubMed, EMBASE, Web of Science, and Cochrane Library until 12 April 2022. To compare the effectiveness and safety of endothelin receptor antagonists (ERAs), phosphodiesterase type 5 Inhibitors (PDE-5i), and prostaglandins (ProA) in the treatment of pediatric PAH, we investigated six hemodynamic parameters, four respiratory parameters, intensive care unit (ICU) stay duration, length of hospital stay, and two safety outcomes.ResultsA total of 27 randomized controlled trials (RCTs) were included in the meta-analysis with 1,574 pediatric participants. The duration of mechanical ventilation was shorter for patients using bosentan, sildenafil, and ProsA, compared with that for patients using the placebo. Bosentan helped to shorten more time for mechanical ventilation than ProsA did, while ProsA was more effective than sildenafil in this respect. As for the length of stay in the ICU, patients administered by ProsA or sildenafil needed shorter ICU stay, compared to those using the placebo, while ProsA was more effective for shortening ICU stay time. In light of safety outcomes, there was a statistically significant difference between the sildenafil and the placebo group. Sildenafil surpassed ProsA in reducing the incidence of pulmonary hypertension (PH) crisis.ConclusionsERAs were more effective than ProsA in shortening the duration of mechanical ventilation, while ProsA were better for shortening the duration of mechanical ventilation and ICU stay than PDE-5i. PDE-5i were found to generate more benefits in decreasing the occurrence of PH crisis, though further investigation is warranted.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=351505.
High-pass filter settings and the role and mechanism of discrete ventricular electrograms in left bundle branch pacing
Authors: Shen Jiabo , Jiang Longfu , Wu Hao , Li Hengdong , Zhang Lu , Zhong Jinyan , Zhuo Shanshan , Pan Lifang 
Published: January 2023

ObjectiveThe characteristics of discrete intracardiac electrogram (EGM) in selective left bundle branch (SLBB) pacing (SLBBP) have not been described in detail previously. This study aimed to examine the effect of different high-pass filter (HPF) settings on discrete local ventricular components in an intracardiac EGM and to analyze its possible mechanisms.MethodsThis study included 144 patients with indications of permanent cardiac pacing. EGMs were collected at four different HPF settings (30, 60, 100, and 200 Hz) with a low-pass filter at 500 Hz, and their possible mechanisms were analyzed.ResultsLBBP was successfully achieved in 91.0% (131/144) of patients. SLBBP was achieved in 123 patients. The occurrence rates of discrete local ventricular EGM were 16.7, 33.3, 72.9, and 85.4% for HPF settings of 30, 60, 100, and 200 Hz, respectively. The analysis of discrete EGM detection showed significant differences between the different HPF settings. By using the discrete local ventricular component and isoelectric interval as the SLBB capture golden standard, the results of EGMs revealed that the 30 Hz HPF has a sensitivity of 19% and specificity of 100%. The 60 Hz HPF had a sensitivity of 39% and a specificity of 100%. The 100 Hz HPF had a sensitivity of 85% and a specificity of 100%. The 200 Hz HPF had a sensitivity of 100% and specificity of 100%.ConclusionAn optimal HPF setting of 200 Hz is recommended for discrete local ventricular EGM detection. A discrete local ventricular EGM should exhibit an isoelectric interval. A steep deflection and high-frequency ventricular EGM morphology nearly identify an intrinsic EGM morphology.
The effect of acute aerobic exercise on arterial stiffness in individuals with different body fat percentages: A cross-sectional study
Authors: Huang Zegui , Chen Guanzhi , Wang Xianxuan , Zang Yiran , Yue Qing , Cai Zefeng , Ding Xiong , Chen Zekai , Cai Zhiwei , Wu Kuangyi , Zheng Huancong , Wu Weiqiang , Wu Shouling , Chen Youren 
Published: January 2023

BackgroundBody fat percentage were positively correlated with arterial stiffness, but the acute change in arterial stiffness after aerobic exercise in individuals with different body fat percentages remains unclear. This study was aimed to determine the effect of acute aerobic exercise on arterial stiffness in individuals with different body fat percentages.MethodsIndividuals who both participated in the seventh survey of the Kailuan study and the fifth iteration of National Physical Fitness Monitoring were enrolled in our study. All participants underwent measurement of brachial–ankle pulse wave velocity, blood pressure, and heart rate before and after a two-stage load test on cycle ergometry. Additionally, the generalized linear model was established to analyse between-group differences of the change in brachial–ankle pulse wave velocity before and after exercise for individuals with different body fat percentages.ResultsThe participants (N = 940, 36.8 ± 7.7years old, all male) were divided into: Q1 10.0–19.3%, Q2 19.3–23.3%, Q3 23.3–27.1% and Q4 27.1–37.7% by body fat percentage quartile. Overall, after exercise, brachial–ankle pulse wave velocity decreased significantly (before, 1,375.1 ± 209.1; after, 1,341.5 ± 208.0cm/s; p &lt; 0.01). After adjusting for confounding factors, the generalized linear model showed that the β values and 95% confidence interval (CI) of Q1, Q2 and Q3 groups were −38.1 (95% CI: −57.3, −19.0), −8.5 (95% CI: −25.8, 3.7),−3.7 (95% CI: −20.5, 13.0), respectively, when compared with Q4. For an increase in body fat percentage by one standard deviation (5.8%), β = 14.5 (95% CI: 7.3, 21.6). Similar results were obtained in sensitivity analyses.ConclusionsAcute aerobic exercise had a positive effect on the arterial stiffness of adults with different body fat percentages. Compared with individuals with high body fat percentages, the arterial stiffness of people with low body fat percentages had significant reduction after exercise.