bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Design and Evaluation of a Novel Therapeutic Agent
Against the Spike Protein as a Novel Treatment Strategy for
COVID-19 Treatment
Authors: Sarmadi Soroush , Rahbar Mohammad Reza , Najafi Hamideh , Chukwudozie Onyeka S. , Morowvat Mohammad Hossein 
Published: May 2023

Background:
Coronavirus disease 2019 (COVID-19) is a viral respiratory disease
that is associated with severe damage to other human organs. It causes by a novel
coronavirus, and it is spreading all over the world. To date, there is some approved vaccine
or therapeutic agent which could be effective against this disease. But their effectiveness
against mutated strains is not studied completely. The spike glycoprotein on the surface of
the coronaviruses gives the virus the ability to bind to host cell receptors and enter cells.
Inhibition of attachment of these spikes can lead to virus neutralization by inhibiting viral
entrance.

Aims:
In this study, we tried to use the virus entrance strategy against itself by utilizing virus
receptor (ACE-2) in order to design an engineered protein consisting of a human Fc antibody
fragment and a part of ACE-2, which reacts with virus RBD, and we also evaluated
this interaction by computational methods and in silico methods. Subsequently, we have
designed a new protein structure to bind with this site and inhibit the virus from attaching
to its cell receptor, mechanically or chemically.

Methods:
Various in silico software, bioinformatics, and patent databases were used to retrieve
the requested gene and protein sequences. The physicochemical properties and possibility
of allergenicity were also examined. Three-dimensional structure prediction and
molecular docking were also performed to develop the most suitable therapeutic protein.

Results:
The designed protein consisted of a total of 256 amino acids with a molecular
weight of 28984.62 and 5.92 as a theoretical isoelectric point. Instability and aliphatic index
and grand average of hydropathicity are 49.99, 69.57 and -0.594, respectively.

Conclusions:
In silico studies can provide a good opportunity to study viral proteins and
new drugs or compounds since they do not need direct exposure to infectious agents or
equipped laboratories. The suggested therapeutic agent should be further characterized in
vitro and in vivo.
A Review on Soft Exoskeletons for Hand Rehabilitation
Authors: Tang Dedong , Lv Xin , Zhang Yongde , Qi Lingzhi , Shen Chengcheng , Shen Wenshuo 
Published: May 2023

Background:
How to enhance the quality of life for the elderly has emerged as a key issue in many nations due to the ageing population. Stroke is the most prevalent disease among the elderly; specifically, the hand dysfunction caused by stroke is also a powerful obstacle to the daily life of the elderly. Soft Exoskeletons for Hand Rehabilitation (SEHRs) have become a major trend for the future due to the increasing demand for hand rehabilitation.

Objective:
To provide a reference for readers in this field by introducing the most recent research developments in the field of SEHR, including their classification and properties.

Methods:
By reviewing different types of hand rehabilitation exoskeleton research papers and patents, the advantages and disadvantages, differences, and applications of various SEHRs were summarized.

Results:
According to the driving mode and realizing the function of SEHRs, the structure characteristics of SEHRs are analyzed and compared. The key problems and future development trends of SEHRs were expounded.

Conclusion:
According to the driving method, the research shows that SEHRs can be divided into Air-Driven Soft Exoskeletons for Hand Rehabilitation (ADSEHRs), Motor-Driven Soft Exoskeletons for Hand Rehabilitation (MDSEHRs), and Hybrid-Driven Soft Exoskeletons for Hand Rehabilitation (HDSEHRs). Future research is required to further optimize the flexibility and adaptability of soft exoskeletons, improve their accuracy and sensitivity, and enhance human-machine interaction with the human hand.
Trust Computational Model for IoT using Machine Learning
Authors: Marigowda Chikkade Krishnegowda , J Thriveni , Subrahmanyam Gowrishankar , Rajuk Venugopal Kuppanna , A Muthyamala 
Published: May 2023

Aims and Background:
The Internet of Things has evolved over the years to a greater extent,
where objects communicate with each other over a network. Heterogenous communication between
the nodes leads to a large amount of information sharing, and sensitive information could be
shared over the network. It is important to maintain privacy and security during information sharing to
protect devices from communicating with malicious nodes.

Objectives and Methodology:
The concept of trust was introduced to prevent nodes from communicating
with malicious nodes. A trust computation model for the IoT based on machine learning concepts
was designed, which evaluates trust based on the Trust Marks. There are three trust marks, out
of which two are evaluated. The three trust marks are knowledge, experience, and reputation.
Knowledge trust marks are evaluated separately based on their trust property mathematical formulations,
and then based on these properties, machine learning-based algorithms are applied to train the
model to classify the objects as trustworthy and untrustworthy.

Results:
The effectiveness of the Knowledge Trust Mark is measured by a simulation and confusion
matrix. The accuracy of the trained model is shown by the accuracy score. The trust computational
model for IoT using machine learning shows higher accuracy in classifying the objects as trustworthy
and untrustworthy.

Conclusion:
The experience trust mark is evaluated based on its properties, and the behaviour of the
experience is shown over time graphically.
Antimicrobial Compounds from Microorganisms-Associated with Selected
Desert Flora
Authors: Tawfik Kamilia , AlBekiry Daliah , Hamdan Eman , Ayas Mahria , Almousa Amal 
Published: May 2023

Background:
The immense genetic variety found in plants and microbes provides a plethora of opportunities for human advancement in the creation of medicine. Microorganisms have been exceptionally rich sources of drugs. Nowadays, the emergence of new infectious diseases and the resistance of some pathogenic microbes necessitates further attempts to find new antimicrobial agents in the fight against infections.

Objective:
The main goal of this study was to explore and evaluate the biologically active secondary metabolites from selected desert flora-associated microorganisms.

Methods:
This was achieved through the isolation of bacteria and fungi associated with plants selected from diverse parts of the Saudi Arabian desert. This study was directed to test the optimal microbial culture composition for the production of biologically active metabolites against pathogenic microbes.

Results:
The produced secondary metabolites showed profound antibiosis activities. Some of which were comparable to or more potent than some of the currently used antibiotics.

Conclusion:
These findings lay the foundation for further discoveries of new metabolites that are urgently needed to face the uprising microbial resistance and mutations that the whole world is continuously suffering from.
Effects of Active Video Games in Patients With Cancer: Systematic Review
Authors: Peyrachon Romane , Rébillard Amélie 
Published: May 2023

Background
Physical activity (PA) is now considered an adjuvant therapy in cancer treatment; nevertheless, multiple barriers could reduce PA engagement during treatment. Active video games (AVGs) lead to the achievement of mild- to moderate-intensity PA and represent a promising tool for regular movement and exercise.

Objective
This paper aims to review the current literature and provide updated content on the physiological and psychological effects of AVG-based interventions in patients with cancer undergoing treatment.

Methods
Four electronic databases were investigated. Studies reporting on AVG interventions delivered to patients undergoing treatment were included. A total of 21 articles (17 interventions) were identified for data extraction and quality assessment.

Results
A total of 362 patients with cancer participated in the studies (number of participants 3-70). The majority underwent treatment for breast, lung, prostate, hematologic, or oral or laryngeal cancer. The types and stages of cancer varied in all studies. Participants ranged in age from 3 to 93 years. Four studies included patients with pediatric cancer. The duration of interventions ranged from 2 to 16 weeks, with a minimum of 2 sessions per week and a maximum of 1 daily session. Sessions were supervised in 10 studies, and 7 included home-based interventions. AVG interventions improved endurance, quality of life, cancer-related fatigue, and self-efficacy. Effects were mixed on strength, physical function, and depression. AVGs did not affect activity level, body composition, or anxiety. Compared with standard physiotherapy, physiological effects were lower or similar, and psychological effects were higher or similar.

Conclusions
Overall, our results suggest that AVGs can be recommended to patients undergoing cancer treatment, given the physiological and psychological benefits. When AVGs are proposed, supervision of the sessions should be considered as it can limit dropouts. In the future, it is important to develop AVGs that combine endurance and muscle strengthening, with the possibility of achieving moderate to high exercise intensity, depending on the physical abilities of the patients, as indicated in the World Health Organization’s recommendations.
Application of Artificial Intelligence in Geriatric Care: Bibliometric Analysis
Authors: Wang Jingjing , Liang Yiqing , Cao Songmei , Cai Peixuan , Fan Yimeng 
Published: May 2023

Background
Artificial intelligence (AI) can improve the health and well-being of older adults and has the potential to assist and improve nursing care. In recent years, research in this area has been increasing. Therefore, it is necessary to understand the status of development and main research hotspots and identify the main contributors and their relationships in the application of AI in geriatric care via bibliometric analysis.

Objective
Using bibliometric analysis, this study aims to examine the current research hotspots and collaborative networks in the application of AI in geriatric care over the past 23 years.

Methods
The Web of Science Core Collection database was used as a source. All publications from inception to August 2022 were downloaded. The external characteristics of the publications were summarized through HistCite and the Web of Science. Keywords and collaborative networks were analyzed using VOSviewers and Citespace.

Results
We obtained a total of 230 publications. The works originated in 499 institutions in 39 countries, were published in 124 journals, and were written by 1216 authors. Publications increased sharply from 2014 to 2022, accounting for 90.87% (209/230) of all publications. The United States and the International Journal of Social Robotics had the highest number of publications on this topic. The 1216 authors were divided into 5 main clusters. Among the 230 publications, 4 clusters were modeled, including Alzheimer disease, aged care, acceptance, and the surveillance and treatment of diseases. Machine learning, deep learning, and rehabilitation had also become recent research hotspots.

Conclusions
Research on the application of AI in geriatric care has developed rapidly. The development of research and cooperation among countries/regions and institutions are limited. In the future, strengthening the cooperation and communication between different countries/regions and institutions may further drive this field’s development. This study provides researchers with the information necessary to understand the current state, collaborative networks, and main research hotspots of the field. In addition, our results suggest a series of recommendations for future research.
Overview of international and Moscow experience in urban renovation
Authors: Kolobova Svetlana V. 
Published: May 2023

Introduction. The problem of rehabilitation and modernization of panel residential buildings covered many European countries in the nineties. The renovation programme started in Moscow in 2017. Despite the typical panel mass housing construction in European countries and in Russia, there are still many urban planning, architectural and construction differences, and therefore different methods of residential renovation have been adopted. Considerable positive and negative construction experience has been accumulated over the past period which should be taken into account for the extension of the renovation to Russian regions.
Materials and methods. The analysis of socio-economic methods of rehabilitation and modernization of residential buildings in several European countries was carried out, and the experience of residential buildings renovation in Moscow was studied in detail. The organizational and financial conditions for the implementation of residential rehabilitation and renovation programs have been studied and a number of features have been noted.
Results. Based on the studied methods of implementation of rehabilitation, modernization and renovation programs in Euro­pean cities and in Moscow, a table with positive and negative factors was compiled. Considering these factors, a flowchart for the choice of renovation method in relation to the specific built-up area was developed. The socio-economic vector ofthe renovation programme on the management of the housing and communal services has been proposed.
Conclusions. When choosing a method of renovation of residential buildings, it is necessary to consider the interests of residents and business entities. For megacities where the number and density of the population is high, the Moscow model of renovation may be preferable, taking into account positive and negative experience. For small cities in Russia, where low-rise buildings are of historical and architectural value and a population density is low, the European renovation experience can be applied. When developing renovation programs, it is important to maintain a balance between new construction and the preservation of historically established urban development.
Corruptive Factors in Local Government (Case of St. Petersburg)
Authors: Semenov V. A. , Ereshkin V. V. 
Published: May 2023

In the new history of present states, one of the main risks to the socio-economic development of society is corruption. The fight against it is based on the development of normative and legal acts, prevention and prevention, information and investigative activities, and is expressed in the form of deterrence and counteraction.The fundamental regulatory framework is the “United Nations Convention against Corruption” (adopted in New York on October 31, 2003 by Resolution 58/4 at the 51st plenary session of the 58th UN General Assembly), the Federal Law “On Countering Corruption” of 12/25/2008 N 273-FL. At the same time, to date, combating corruption in local government is regulated superficially and is formal in character. Due to the actual closed nature of the activities and peculiarities of the functioning of local government, the issues of corruption are not fully studied in order to provide effective prevention and counteraction.The possibility of a detailed study of corruptionogenic factors of local government and the development of methods of counteraction became possible after the elections of 2019, after which non-systemic municipal deputies were elected to the representative bodies of local government. Exercising the powers in the representative body of local government, municipal deputies independent from the territorial executive bodies of state power were able to study the specifics of the functioning of local government, make public the issues of the problem field, identify vulnerable places in the activities, take response measures and make appropriate practical conclusions.The purpose of this article is to establish the causes of the emergence of corruption in local government on the example of a separate municipality of the MO Svetlanovskoye of St. Petersburg. Study of the causes of the emergence of corruptionogenic factors, search and proposal of possible ways to address the issue of effective counteraction to corruption in local government in the new conditions of life of modern society.On the basis of the study the authors declare the need to take specific measures of response of the public authorities of the subject of the Russian Federation and the representative body of local government, aimed at creating certain conditions for effective counteraction and prevention of corruption, minimizing the consequences of corruptogenic factors in the modern conditions of democratic functioning of local government.
PENDIDIKAN KESEHATAN MENCEGAH DAN MENGATASI HIPERTENSI DI IRNA 7 RS. UNIVERSITAS AIRLANGGA
Authors: Nimah Lailatun , Dwi C Marthalia Oktavianty , Pratama Victoria Putri , Biru Mustika Milenia Dwi Tunjung 
Published: May 2023

Tekanan Darah Tinggi (hipertensi) merupakan peningkatan tekanan darah di dalam arteri. Biasanya hipertensi tanpa gejala, dimana tekanan yang abnormal tinggi di dalam arteri menyebabkan meningkatnya risiko terhadap stroke, aneurisma, gagal jantung, serangan jantung dan kerusakan ginjal. Artikel ini berupaya memberikan gambaran dan penjelasan terkait program kerja pendidikan kesehatan pada pasien dan keluarga tentang hipertensi. Metode dalam penulisan artikel ini menggunakan pendekatan pre test dan post test yang bermaksud memberikan gambaran mendetail terkait program kerja pendidikan kesehatan selama pelaksanaan Praktik Keperawatan Dasar sekaligus menjelaskan langkah-langkah mulai dari sebelum pendidikan kesehatan, hingga output dari program pendidikan kesehatan tersebut. Hasil pre test dan post test menunjukkan peningkatan pemahaman materi dengan baik yang ditunjukkan dengan jawaban yang benar. Hasil wawancara yang dilakukan pasien dan keluarga merasa puas dengan pendidikan kesehatan yang dilakukan. Mereka mengatakan bahwa dulu mereka menganggap hipertensi adalah penyakit biasa yang pasti akan diderita pada usia tua.
Experience with the use of Hizentra, an immunoglobulin preparation for subcutaneous administration, in patients with primary immunodeficiency diseases
Authors: Avedova A. Ya. , Rodina Yu. А. , Yukhacheva D. V. , Burlakov V. I. , Deripapa E. V. , Shcherbina A. Yu. 
Published: May 2023

Immunoglobulin replacement therapy is the gold standard of treatment for patients with antibody deficiencies. We aimed to investigate the efficacy and safety of replacement therapy with subcutaneous immunoglobulin (SCIG) Hizentra in patients with primary immunodeficiencies. This study was approved by the Independent Ethics Committee and the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. All patients and / or their legal representatives gave informed consent for this treatment. In our study, 12 patients under 18 years of age with various forms of primary immunodeficiencies who had previously received intravenous immunoglobulin were switched to SCIG treatment to receive weekly infusions of Hizentra. Therapy SCIG was administered weekly at a dose of 0.1–0.15 g/kg by rapid push infusion. All patients received Hizentra for at least 3 months. None of the patients included in the study developed severe infections. Immunoglobulin G levels in blood after 3 months of SCIG therapy were significantly higher compared to those achieved on previous intravenous immunoglobulin therapy. There were no severe adverse events associated with Hizentra administration. Our study demonstrated Hizentra to be effective and safe for the treatment of children with various forms of primary immunodeficiencies.
Comparison of a commercially available veterinary digital refractometer to analogue refractometer and laboratory chemistry analyzer in the evaluation of canine serum total protein
Authors: Carignan Katie , Thevelein Britt A. L. , Brainard Benjamin M. , Koenig Amie 
Published: May 2023

Abstract

OBJECTIVE
To assess the agreement between measurements of total protein (TP) concentrations in canine serum samples between a commercially available veterinary digital refractometer (DR), an analog handheld refractometer (AR), and a laboratory-based chemistry analyzer (LAB). An additional objective was to assess the effects of various potential interferents (ie, hyperbilirubinemia, increased BUN, hyperglycemia, hemolysis, and lipemia) on DR measurements.

SAMPLE
108 canine serum samples.

PROCEDURES
Serum samples were measured in duplicate on the DR, which reported TP concentration, assessed via optical reflectance and critical angle measurement. These serum samples were also assessed on the AR and LAB for comparison. Serum samples with grossly visible lipemia, hemolysis, and icterus were noted. Medical records were retrospectively assessed to determine concentrations of BUN, glucose, and bilirubin.

RESULTS
Method comparisons among the various data generated by the analyzers were completed using linear regression, Bland Altman, and calculation of intraclass coefficients. Mean bias between DRTP and LABTP in samples without potential interferents was 0.54 g/dL with 95% limits of agreement of –0.17 to 1.27 g/dL. One-third of DRTP samples without potential interferents had > 10% difference from their LABTP comparison. Interferents, particularly marked hyperglycemia, can result in inaccurate measurements on the DR.

CLINICAL RELEVANCE
There was a statistically significant difference between DRTP and LABTP measurements. TP measurements in samples with any potential interferent, particularly hyperglycemia, should be assessed cautiously on DR and AR.
People Exchange: A British Council’s Post-Colonial Distinguished Cultural Investment
Authors: Sahel Malika 
Published: May 2023

Abstract
Since the beginning of the post-colonial era, preserving already acquired links and pioneered cultural ties cultivated during the colonial era with overseas people, has remained a priority for the British Council. The latter did not mince efforts to protect British interests, particularly when strong competition from more powerful countries could threaten British position on the international scene. Thus, the Council’s People Exchange activity was considered as one of the most important cultural investment on which the British Council could rely to back Britain in times of turbulences.
Theoretical Approach to Enhance Information Literacy and Lifelong Learning Through Montessori Methodology
Authors: Boté Juan-José 
Published: May 2023

Abstract
This work is a theoretical proposal to apply the strongest points from the Montessori methodology to improve information literacy through lifelong learning. Since lifelong learning includes cognition and skills, information literacy permits the solving of problems as well as effectively communicating and interacting with the environment. This means having abilities and skills that through adequate training permit the acquisition of new knowledge or improving knowledge on any topic, within a formal or informal environment. It also could permit seeking, managing, and comparing information. However, there are some questions that arise with older individuals. Since lifelong learning usually takes place in informal environments, getting resources to learn may be a difficult task. Learning difficulties also involve information abstraction, text comprehension, and technological barriers. Consequently, lifelong learning and information literacy are likely to be affected. The question comes up as to which pedagogical methodology may fit better for lifelong learning and the acquisition of better information literacy skills. Task breakdown, guided repetition, and ordering activities from simple to complex are essential keys in the Montessori methodology, which help not only older people but also children to enhance information literacy as well as assist with lifelong learning.