bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of low-impact development facility area based on surrogate model
Authors: Feng Jing , Yang Yuanyuan , Li Jianzhu 
Published: June 2023

Abstract
Low impact development (LID) facilities are an important element of sponge cities. In this paper, a system of siting suitability indicators was established for three types of LID facility: green roofs, permeable pavement and rain gardens. Based on the superposition analysis tool of ArcGIS, the suitable area and its upper limit of the LID facilities in each sub-catchment were determined respectively. A non-linear function of the LID deployment area and rainfall characteristics was constructed separately using a multi-layer perceptron (MLP) as a surrogate model. The results showed that: (1) The upper limit of the suitable area for the deployment of green roofs in each sub-catchment ranged from 5.46% to 22.87%. The upper limit of the suitable layout area for permeable pavement was between 8.31% and 23.65%. The maximum percentage of suitable area for rain gardens was between 18.12% and 36.95%. (2) The final layout scheme of the LID facilities was selected when the total outflow from the sub-catchment was 10,700,000 m3, the peak discharge was 3.49 m3/s and the total investment in construction and management was 0.76 billion Yuan. (3) The total outflow reduction rate of the sub-catchment under the LID model ranged from 32.15% to 40.29%, and the peak discharge reduction rate ranged from 17.93% to 36.20%. (4) The computation time of the surrogate optimization model could be compressed to 0.37% of that of SWMM violent optimization. The surrogate optimization model had both good convergence measure and diversity measure. This paper provides new ideas for the optimal deployment of LID facilities.
Smart Embedded Health Monitoring System and Secure Electronic Health Record (EHR) Transactions Using Blockchain Technology
Authors: V VijayaDeepa , AL Sriram , B Thamotharan , Mahto Dindayal , R Venkatesan , P Rajendiran 
Published: June 2023

Abstract
The proposed work integrates a smart Embedded health monitoring system with IoT. The data that is sensed and analyzed from the system is secured using blockchain technology and is transmitted and further analyzed. Blockchains are used in various sectors. Mainly they are welcomed for their secure transactions and the privacy that we can ensure through it. In this paper, our proposed system explored its uses in the Health Care sector. The health sector is where information is of privacy concern for patients and needed information for doctors treating them. Blockchain is the best-suited solution for Identity and Access Management (IAM) needed in the HealthCare sector. As blockchains have different types named public and private blockchains, We recommend private blockchains be implemented where no anyone can make transactions and mine the transactions. Patients, Doctors, and hospital organizations care for their privacy, and authorized access to others’ data, is the reason for the choice of the private blockchain. Adding to the IAM, blockchain also accounts for flexibility, decentralization, and an Immutable ledger. Those operations are authenticated and authorized by a blockchain Admin who has no relationship with the entities that exist in the network. The owner of the data is given the sole control of permitting access to their data. Our system asks patients for permission to be given to any doctor who is requesting access to that data. Also, patients can permit a doctor they want within the network. Hyperledger uses no online currencies hence no miners to wait for. This is important as it reduces the waiting time for a transaction to be verified. REST API is used for collecting information requested from the blockchain and presenting it to the end-users. Our system provides a secure, reliable, and IAM-included network in a webpage that can be accessed across all devices.
The value of Heparin-binding protein in bronchoalveolar lavage fluid in ARDS：a case control study
Authors: Liu Yang , Zhang Haitao , Wang Xuebing , Ma Shaolin 
Published: June 2023

Abstract
Background
Heparin-binding protein (HBP) play an important role in ARDS. Plasma HBP is a good biomarker on predicting ARDS, but the value of bronchoalveolar lavage fluid (BALF) HBP in ARDS has not been studied.
Methods
We use cecum ligation and puncture (CLP) to induce ARDS model in mice and study plasma HBP, BALF HBP and lung injury severity, lung wet/dry ratio and total protein levels in BALF. Also we included a total of 44 patients with ARDS and 38 patients with cardiogenic pulmonary edema (CPE). We compared BALF and plasma HBP levels between the two groups and studied their correlation.
Results
Animal study show, compare with sham group, CLP group mice show significant higher lung WD Ratio(P = 0.002), BALF protein(P < 0.001), BALF HBP(P = 0.013) and plasma HBP(P = 0.003) than sham group. Lung injury index WD Ratio and BALF protein have significant correlation with plasma HBP and BALF HBP in CLP group mice. Plasma and BALF HBP also have significant correlation (P = 0.026). Study in patients showed there are significant difference in BALF HBP (P < 0.001), BALF Protein (P < 0.001) and Plasma HBP (P < 0.001) between ARDS and CPE patients. There are significant correlation between P/F ratio and BALF HBP(P = 0.005) and plasma HBP(P = 0.021).We also found a strong correlation between BALF HBP and plasma HBP levels (P < 0.001).
Conclusions
Our study suggests that both in animal or human, Both BALF and Plasma HBP were significantly increased during lung injury, and were significantly correlated with the severity of lung injury, while BALF was better correlated with lung injury. BALF is associated with elevated plasma HBP levels. BALF HBP could be used as a biomarker to guide the diagnosis and treatment of ARDS.
Factors associated with exclusive breastfeeding in neonatal “Near Miss” in Brazil
Authors: Marano Daniele , Pereira Theonas Gomes , Fonseca Vânia Matos 
Published: June 2023

Abstract
Objective To assess the association between sociodemographic and perinatal factors and hospital practices to encourage exclusive breastfeeding in near miss neonates in maternity hospitals.Methods This is a prospective cohort with 518 cases of neonatal near miss evaluated between 2011 and 2012. Exclusive breastfeeding at hospital discharge and 45 days after delivery were dependent variables of the study. The sociodemographic and perinatal factors of the puerperal women and hospital practices to encourage breastfeeding were independent variables.Results Mothers with incomplete elementary education were more likely to have exclusive breastfeeding at discharge. Women who did not offer the breast to the newborn in the joint accommodation were less likely to be breastfeeding exclusively at discharge. Primiparity and having the newborn in the delivery room were associated with exclusive breastfeeding after 45 days of delivery.Conclusion Exclusive breastfeeding in neonatal near misses was associated with maternal characteristics and hospital practices.
Construction of prognostic model and molecular subtypes based on endoplasmic reticulum stress-related lncRNAs in endometrial cancer
Authors: Wang Caixia , Luo Yue , Yin Rutie 
Published: June 2023

Abstract
Background
Recently, TCGA molecular typing of endometrial cancer is a research hotspot and plays an important role in clinical practice. However, microsatellite instability hypermutated and low copy number groups still lack a clear prognostic significance. Here, we established a prognostic model and molecular subtypes on the basis of ten ERS-related lncRNAs in UCEC, which complement TCGA molecular subtypes.
Methods
Significant ERS-related lncRNAs were identified through co-expression and differential analysis of the TCGA cohort. Using least absolute shrinkage and selection operator (LASSO), univariate and multivariate Cox regression methods, we collected ten ERS-related lncRNAs, developed a prognostic model and molecular subtypes, and analyzed overall survival (OS), tumor microenvironment (TME), and drug susceptibility. Afterwards, we validated the predictive accuracy of the ERS score and developed a nomogram to optimize the ERS prognostic model.
Results
High ERS score and cluster 1 predicted shorter OS in UCEC. ERS score and molecular subtypes were related to immune responses, checkpoints, and drug sensitivity. To sum up, our research indicates that ERS prognostic model and molecular subtypes contribute to the formation of the diverse and complex TME and predict OS as well as drug sensitivity in UCEC.
Conclusions
Collectively, we constructed a prognostic model and molecular subtypes based on ten ERS-related lncRNAs. Findings from this study will provide a deeper understanding of how ERS-related lncRNAs function in UCEC, allow for new directions in prognostic assessment, and help develop personalized treatments for UCEC patients.
Single-cell transcriptome sequencing reveals alfalfa root tip developmental landscape
Authors: Yan Zhenfei , Yan Su , He Yong , Ma Lichao , Li Shuo , Liang Jian , Zhang Xiaoyuan , Gong Yayun , Cong Lili , Wang Zengyu , Yang Guofeng 
Published: June 2023

Abstract

Background: Root development relies on establishing stem cells and meristems, which differentiate into different heterogeneous cell types with varying temporal and spatial gradients. Constructing the developmental trajectories and dissecting the transcriptional regulatory networks of these cells, therefore, improves the functional understanding of the stem cells and meristems of dicot root tips. Single-cell RNA sequencing (scRNA-seq) has more advantages in obtaining the dynamic expression of genes in time and space than traditional RNA sequencing (RNA-seq). Pseudo-time trajectory analysis enables a re-study of the developmental process of root tips, stem cells, and meristems.
Results: This study used high-throughput single-cell RNA sequencing to analyze 11,344 cells of the 5-day-old alfalfa root tips and identified 17 cell clusters and cluster-specific marker genes. Pseudo-time analysis of the single-cell transcriptome data using an unsupervised algorithm enabled the reconstruction of developmental trajectories between cells in different developmental states. The gene expression status during the differentiation of meristem cells was also revealed.
Conclusions: Our study constructed a single-cell transcriptomic map of alfalfa roots and revealed heterogeneity among the different root cells. The study also conducted a single-cell resolution of the root cells during differentiation and intermediate transitions. The gene expression characteristics of the living cells provide valuable information and a resource library for studying the developmental biology of alfalfa.
Insulin-induced Gene 2 Protects against Hepatic Ischemia-reperfusion Injury via Metabolic Remodeling
Authors: Wu Yichao , Li Changbiao , Khan Abid Ali , Chen Kangchen , Su Renyi , Shengjun Xu , Sun Yiyang , Gao Fengqiang , Wang Kai , Wang Xiaodong , Lian Zhengxing , Wang Shuo , Yu Mengyuan , Hu Xin , Yang Fan , Zheng Shusen , Qiu Nasha , Liu Zhikun , Xu Xiao 
Published: June 2023

Abstract
Background:Hepatic ischemia-reperfusion (IR) injury is the primary reason for complications following hepatectomy and liver transplantation (LT). Insulin-induced gene 2 (Insig2) is one of several proteins that anchor the reticulum in the cytoplasm and is essential for metabolism and inflammatory responses. However, its function in IR injury remains ambiguous.
Methods: Insig2 global knock-out (KO) mice and mice with adeno-associated-virus8 (AAV8)-delivered Insig2 hepatocyte-specific overexpression were subjected to a 70% hepatic IR model. Assessment of liver injury was performed by monitoring hepatic histology, inflammatory responses, and apoptosis. Hypoxia/reoxygenation stimulation (H/R) of primary hepatocytes was used for in vitro experiments. Multi-omics analysis of transcriptomics, proteomics, and metabolomics was used to investigate the molecular mechanisms underlying Insig2.
Results: Insig2 expression was significantly reduced in both clinical samples undergoing LT and the mouse IR model. Our findings showed that Insig2 depletion significantly aggravated IR-induced hepatic inflammation, cell death and injury, whereas Insig2 overexpression caused the opposite phenotypes. The results of in vitro H/R experiments were consistent with those in vivo. Mechanistically, multi-omics analysis revealed that Insig2 is associated with an increase in antioxidant pentose phosphate pathway (PPP) activity. The inhibition of glucose-6-phosphate-dehydrogenase (G6PD), rate-limited enzyme of PPP, rescued the protective effect of Insig2 overexpression exacerbating the liver injury. Finally, our findings indicated that mouse IR injury could be attenuated through the development of a nanoparticle delivery system that enable liver-targeted delivery of substrate (glucose 6-phosphate) of PPP.
Conclusions: Insig2 has a protective function in liver IR by upregulating the PPP activity. This may serve as a viable therapeutic target for alleviating hepatic IR.
The potential coordination benefits in disease control - evidence from rabies elimination efforts in Africa
Authors: Bucher Alvar , Dimov Artemiy , Fink Günther , Chitnis Nakul , Bonfoh Bassirou , Zinsstag Jakob 
Published: June 2023

Abstract
Background
Previous research suggests that dog mass vaccination campaigns can eliminate rabies locally, resulting in large human and animal life gains. Despite these demonstrated benefits, dog vaccination programs remain scarce on the African continent.
Methods
In this paper, we conduct a detailed benefit-cost analysis to demonstrate that the low deployment of dog vaccination campaigns is the result of systematic coordination failure between key stakeholders, resulting in a suboptimal policy equilibrium. Combining the most recent cost and effectiveness data with a mathematical model of rabies transmission, we compute the benefits and costs of multiple strategies for 48 countries in mainland Africa.
Findings
Lack of or incomplete human post-exposure prophylaxis (PEP) and not vaccinating dogs is currently the dominant practice for all countries in Africa. We show that coordinated dog mass vaccination between countries and PEP would lead to the elimination of dog rabies in Africa with total welfare gains of USD 9.5 billion (95% CI: 8.1 – 11.4 billion). Uncoordinated dog mass vaccination between countries and incomplete human PEP have lower welfare gains and don’t lead to the elimination of dog rabies. Nevertheless, for many countries, even with the possibility of reintroduction of rabies from other countries, mass dog vaccination is the dominant strategy in the game-theoretic sense.
Interpretation
Coordinated disease control between African countries can lead to more socially and ecologically equitable outcomes by reducing the number of lost human lives to almost zero and possibly eliminating rabies. African inter-governmental platforms like the African Union Inter-African Bureau for Animal Resources (AU-IBAR) and regional platforms like the Economic Community of West African States (ECOWAS) are best placed to achieve such coordination.
Coexistence of early gastric cancer and benign submucosal lesions mimic invasive cancer: a retrospective multicenter experience
Authors: YANG Huawei , LI Zhen , WEI Zhi , LI Guodong , LI Yi , WU Shanbin , JI Rui 
Published: June 2023

Abstract
Objective:
To present a study to identify the characteristics of coexisting early gastric cancer (EGC) and benign submucosal lesions, with the aim of reducing the adverse consequences of overdiagnosis and overtreatment.
Methods:
In this retrospective study, we searched the endoscopic databases of three tertiary centers. We screened of patients suspected of early gastric cancer submucosal infiltration by conventional endoscopy and ultimately selected for endoscopic submucosal dissection treatment after endoscopic ultrasonography and magnifying endoscopy with narrow-band imaging examination. Patients with coexisting EGC and benign submucosal lesions in histological sections were included. Clinical data and endoscopic images were reviewed. To evaluate the precision of endoscopists' diagnoses for this type of lesion, eight endoscopists with different experiences were recruited to judge the infiltration depth of these lesions and analyze the accuracy rate.
Results:
We screened 520 patients and retrospectively identified 18 EGC patients with an invasive cancer-like morphology. The most common lesion site was the cardia (12/18, 66.67%). The coexisting submucosal lesions could be divided into solid (5/18, 27.78%) and cystic (13/18, 72.22%). The most common type of submucosal lesion was gastritis cystica profunda (12/18, 66.67%), whereas leiomyoma was the predominant submucosal solid lesion (3/18, 16.67%). Ten (55.56%) patients underwent endoscopic ultrasonography; submucosal lesions were definitively diagnosed in 6 patients (60.00%). The accuracy of judgement of the infiltration depth was significantly lower in coexistence with EGC and benign submucosal lesions than in simple EGC (38.50% versus 65.60%, P = 0.0167), especially for inexperienced endoscopists, and the overdiagnosis rate was up to 75.00%.
Conclusions:
We should be aware of the coexistence of EGC and benign submucosal lesions, the most common of which is early cardiac-differentiated cancer with gastritis cystica profunda. Endoscopic ultrasonography is a useful modality for diagnosing these coexisting submucosal lesions.
Text mining and association rules-based analysis of 245 cement production accidents in a cement manufacturing plant
Authors: Wang Bing , Gong Yan , Zhou Jiasheng 
Published: June 2023

Abstract
Accidents such as collapse, fire, suffocation, poisoning, scalding and mechanical injuries occur frequently in cement industries. Understanding the causes of past accidents in cement companies is essential to prevent cement production accidents and reduce safety risks. However, there is currently no cause analysis of accidents that have occurred in cement companies. Hence, this paper takes cement accident cases as the basis of research, proposes a unified report analysis framework, combines data mining technology, probes deeply into the law of cement production accidents, and establishes cement accident causation analysis model to provide a basis for current safety management decisions. Firstly, 245 accident records were collected to categorize the causal factors of cement accidents in this plant according to the LDA model, and then a systematic accident causal analysis method was proposed according to the 24Model to establish a unified report analysis framework. Based on this, an improved Apriori algorithm suitable for multi-dimensional multi-layer cement enterprise accident correlation rule mining was proposed to improve the efficiency of accident mining. Using the improved Apriori algorithm, the correlation between accident causative factors and accident types as well as accident causative factors of cement enterprises was quantitatively mined, and targeted safety management suggestions were put forward.
Lumbar Multifidus Characteristics in University Level Athletes May be Predictors of Low Back Pain and Lower Limb Injury
Authors: Anstruther Meagan , Valentin Stephanie , Dover Geoffrey , Fortin Maryse 
Published: June 2023

Abstract

Background Low back pain (LBP) is highly prevalent in athletes, with lumbar multifidus (LM) atrophy and increased LM cross-sectional area (CSA) reported in athletes with LBP. Decreased LM CSA and thickness have also been previously associated with lower limb injury (LLI) in athletes. Yet, previous research has only investigated connections between LM, LBP, and LLI in small samples of athletes in a single sport at a time. The current study aimed to (1) examine LM morphology and function across a general sample of male and female university level varsity athletes; (2) investigate whether LM characteristics were predictors of LBP and LLI. Methods Exclusion criteria included previous severe spinal trauma or spinal fracture, spinal surgery, observable spinal abnormalities, and pregnancy. Ultrasound images of LM at L5 were acquired in prone and standing. Body composition was assessed with DEXA and a self-reported questionnaire provided demographics and history of injury. Paired t-tests and independent t-tests compared LM measurements between the sides and sex, respectively. Univariate and multivariate logistic regression analyses were used to assess if LM characteristics were predictors of LBP and LLI. Results 134 university varsity athletes (mean age, 21.0 ± 1.5, 84 male) were evaluated. LM CSA was larger on the non-dominant side in both males (non-dominant, 10.54 ± 1.55, dominant, 10.34 ± 1.58, p < 0.05) and females (non-dominant, 8.26 ± 1.32, dominant, 8.11 ± 1.33, p < 0.05) in prone. Increased LM thickness was associated with decreased odds of LBP in the previous 4-week (OR = 0.49 [0.27, 0.88], p = 0.02) and 3-month (OR = 0.43 [0.21, 0.89], p = 0.02) in the multivariable model, while a greater number of years playing at the university level was associated with increased odds of LBP (OR = 1.29 [1.01, 1.65], p = 0.04). Greater LM CSA asymmetry (OR = 1.14 [1.01, 1.28], p = 0.03) and sport (OR = 1.44 [1.04, 1.96], p = 0.02) were significant predictors of LLI in the previous 12 months. Conclusion Leg dominance may play a role in unilateral differences. LM thickness and LM CSA asymmetry were predictors of injury. Preseason screening of LM morphology and function could help identify athletes at risk of LBP and LLI. This could allow coaches, medical staff, and strength and conditioning staff to target these individuals and provide specific injury prevention programs.
Discharge to home from a palliative care unit: impact on survival and factors associated with home death after the discharge: a cohort study
Authors: Murakami Nozomu , Kajiura Shinya , Tanabe Kouichi , Tsukada Kenichiro , Shibata Kazuhiko , Minabe Yoshio , Morita Tatsuya , Hayashi Ryuji 
Published: June 2023

Abstract
Background
Staying at home during the dying process is important for many patients; and palliative care units (PCUs) can help facilitate home death. This study aimed to compare patient survival between those who were discharged to home from a palliative care unit and those who were not, and identify the factors associated with home death after the discharge.
Methods
This retrospective cohort study used a database of the patients admitted to a palliative care unit at Kouseiren Takaoka Hospital in Japan. All consecutive patients admitted to the hospital’s PCU between October 2016 and March 2020 were enrolled. Patient survival and factors potentially associated with survival and place of death were obtained. A total of 443 cancer patients were analyzed, and 167 patients were discharged to home and 276 were not.
Results
Propensity score matching analyses revealed that median survival time was significantly longer in patients who were discharged to home than those who were not (57 vs. 27 days, P < 0.001). Multiple logistic regression analysis identified that worse Palliative Prognostic Index and family members’ desire for home death were significantly associated with home death after their discharge (odds ratio, 1.21 [95% CI, 1.03, 1.44], p = 0.025 and 6.30 [2.32, 17.1], p < 0.001, respectively).
Conclusions
This study found that discharge to home from palliative care units might have some positive impact on patient survival.