bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critically ill severe hypothyroidism: a retrospective multicenter cohort study
Authors: Bourcier Simon , Coutrot Maxime , Ferré Alexis , Van Grunderbeeck Nicolas , Charpentier Julien , Hraiech Sami , Azoulay Elie , Nseir Saad , Aissaoui Nadia , Messika Jonathan , Fillatre Pierre , Persichini Romain , Carreira Serge , Lautrette Alexandre , Delmas Clément , Terzi Nicolas , Mégarbane Bruno , Lascarrou Jean-Baptiste , Razazi Keyvan , Repessé Xavier , Pichereau Claire , Contou Damien , Frérou Aurélien , Barbier François , Ehrmann Stephan , de Montmollin Etienne , Sztrymf Benjamin , Morawiec Elise , Bigé Naïke , Reuter Danielle , Schnell David , Ellrodt Olivier , Dellamonica Jean , Combes Alain , Schmidt Matthieu 
Published: March 2023

Abstract
Background
Severe hypothyroidism (SH) is a rare but life-threatening endocrine emergency. Only a few data are available on its management and outcomes of the most severe forms requiring ICU admission. We aimed to describe the clinical manifestations, management, and in-ICU and 6-month survival rates of these patients.

Methods
We conducted a retrospective, multicenter study over 18 years in 32 French ICUs. The local medical records of patients from each participating ICU were screened using the International Classification of Disease 10th revision. Inclusion criteria were the presence of biological hypothyroidism associated with at least one cardinal sign among alteration of consciousness, hypothermia and circulatory failure, and at least one SH-related organ failure.

Results
Eighty-two patients were included in the study. Thyroiditis and thyroidectomy represented the main SH etiologies (29% and 19%, respectively), while hypothyroidism was unknown in 44 patients (54%) before ICU admission. The most frequent SH triggers were levothyroxine discontinuation (28%), sepsis (15%), and amiodarone-related hypothyroidism (11%). Clinical presentations included hypothermia (66%), hemodynamic failure (57%), and coma (52%). In-ICU and 6-month mortality rates were 26% and 39%, respectively. Multivariable analyses retained age > 70 years [odds ratio OR 6.01 (1.75–24.1)] Sequential Organ-Failure Assessment score cardiovascular component ≥ 2 [OR 11.1 (2.47–84.2)] and ventilation component ≥ 2 [OR 4.52 (1.27–18.6)] as being independently associated with in-ICU mortality.

Conclusions
SH is a rare life-threatening emergency with various clinical presentations. Hemodynamic and respiratory failures are strongly associated with worse outcomes. The very high mortality prompts early diagnosis and rapid levothyroxine administration with close cardiac and hemodynamic monitoring.
Territories in Transition: how social contexts influence wildland fire adaptive capacity in rural Northwestern European Mediterranean areas
Authors: Uyttewaal Kathleen , Prat-Guitart Núria , Ludwig Fulco , Kroeze Carolien , Langer E. R. 
Published: March 2023

Abstract
Background
Rural and semi-rural areas are complex and dynamic social-ecological systems, many of which have experienced profound impacts from wildland fires, particularly this decade. Under uncertain climate change conditions, these areas require new adaptive strategies to support landscape and community resilience. While these areas vary widely, some patterns of local social context have become apparent through wildland fire research. These patterns can help decision-makers better understand what influences communities’ abilities to adapt to fire. We focused our study on a northwestern European Mediterranean context, where communities are adapting to wildland fire and other climate change impacts through varied programs and policies. This area is composed of diverse landscapes, cultures, histories, languages and governance structures, but it also shares fire-based learning networks and collaborations, providing a sound indicator of shared elements of social context. Our study analyzed local social contexts in rural areas of Spain, Italy and France and assessed how these may inform adaptive capacity to wildland fire. A two-step process achieved this: (1) a targeted literature review of local social context elements as they relate to wildland fire in Mediterranean Europe; and (2) conducting semi-structured interviews with 20 key experts in rural Mediterranean areas, including fire managers, foresters, local administrators and technicians.

Results
Results illustrate numerous shared patterns in rural social contexts that influence local fire adaptive capacity. Dynamic local relationships among residents, local fire knowledge and environmental movements, the role of fire managers and administrators, and embeddedness in broader sociopolitical trends all interconnect to influence local fire adaptive capacity. Some key elements of context can act as primary enablers or barriers to this process, such as the presence (or lack) of local fire knowledge, and the opportunity (or lack thereof) for sustainable local economic development. Results also demonstrate high diversity in terms of governance structures and development trajectories.

Conclusions
We argue the need for deepened empirical transdisciplinary research to connect fire and land management tailored to local characteristics. Centering these local perspectives and diverse cultural values is necessary to foster long term adaptive wildland fire management strategies in rural Mediterranean communities and globally.
Remixing to Queer the Archives of Diaspora: Qajar Photography and the Persian Carpet
Authors: Akhtari Nazli 
Published: March 2023

Abstract
This article reveals how engagements with the photographic archives of premodern Iran and the Persian carpet break open transtemporal, affective, and queer interplays in diaspora. Examining a digital remix of a photograph of a Qajar princess, ‘Ismat al-Dowlah, from the archives of nineteenth-century Iran, the article argues that the digital (mis)use of archives exposes what forms such as the Persian carpet and photography erase: each medium's close ties with power, labor, gender, and sexuality. It develops a relational approach to understandings of photography that highlights the performative registers for a diasporic gaze while also troubling the imperial investment in understanding photography's history and its practices as a new technology that developed in the nineteenth century. This work considers how unlearning the history of Qajar photography entails deemphasizing the Qajar's king Naser Al Din Shah's fascination with photography's technological newness and instead exposes what desires his fascination was tethered to. This piece brings into conversation techno-historical overlaps between carpet weaving, the Jacquard machine, and computational arts, opening up critical questions about gender vis-à-vis production, labor, and computation within both carpets and computers as media interface.
Appropriate Feminisms: Ambivalence and Citational Practice in Appropriate Behavior
Authors: Bradbury-Rance Clara 
Published: March 2023

Abstract
Across her body of work in film, television, and digital media, Desiree Akhavan has captured the awkward politics of cultural production for female filmmakers and media-makers. Yet she has also refused to straightforwardly align her work with feminist critiques of dominant cultural production practices, however much she is interpellated by them. Akhavan, a queer woman of color in a racist, sexist, and homophobic industry, negotiates both contemporary feminism's potentials for solidarity and its intersectional shortcomings. Akhavan's autobiographical characters wrestle with the need for social justice while questioning the “appropriate behaviors” demanded by serious commitments to the cause. Her work reveals the ambivalence of feminist attachments. This article reads the queer feminist politics of Akhavan's work, with a particular focus on her debut feature Appropriate Behavior (UK/US, 2014), through the lens of citational practice. The author argues that Akhavan employs citational codes that function in Clare Hemmings's words as a “storytelling tactic,” sustaining normative narratives about feminism's recent past. By employing an ambivalent trope that the author calls citation→disavowal, Akhavan troubles both the dominant cultures she is excluded from and the viability and legibility of her place within the movements that resist them.
Understanding the Unique Challenges Faced by Homeless Patients With Acute Traumatic Neurosurgical Injuries
Authors: Cole Kyril L. , Findlay Matthew C. , Earl Emma , Sherrod Brandon A. , Cutler Christopher B. , Nguyen Sarah , Grandhi Ramesh , Menacho Sarah T. 
Published: March 2023

BACKGROUND:
Homelessness is associated with high risk of acute neurotraumatic injury in the ∼600 000 Americans affected on any given night.

OBJECTIVE:
To compare care patterns and outcomes between homeless and nonhomeless individuals with acute neurotraumatic injuries.

METHODS:
Adults hospitalized for acute neurotraumatic injuries between January 1, 2015, and December 31, 2020, were identified in this retrospective cross-sectional study at our Level 1 trauma center. We evaluated demographics, in-hospital characteristics, discharge dispositions, readmissions, and adjusted readmission risk.

RESULTS:
Of 1308 patients, 8.5% (n = 111) were homeless on admission to neurointensive care. Compared with nonhomeless individuals, homeless patients were younger (P = .004), predominantly male (P = .003), and less frail (P = .003) but had similar presenting Glasgow Coma Scale scores (P = .85), neurointensive care unit stay time (P = .15), neurosurgical interventions (P = .27), and in-hospital mortality (P = .17). Nevertheless, homeless patients had longer hospital stays (11.8 vs 10.0 days, P = .02), more unplanned readmissions (15.3% vs 4.8%, P < .001), and more complications while hospitalized (54.1% vs 35.8%, P = .01), particularly myocardial infarctions (9.0% vs 1.3%, P < .001). Homeless patients were mainly discharged to their previous living situation (46.8%). Readmissions were primarily for acute-on-chronic intracranial hematomas (4.5%). Homelessness was an independent predictor of 30-day unplanned readmissions (odds ratio 2.41 [95% CI 1.33-4.38, P = .004]).

CONCLUSION:
Homeless individuals experience longer hospital stays, more inpatient complications such as myocardial infarction, and more unplanned readmissions after discharge compared with their housed counterparts. These findings combined with limited discharge options in the homeless population indicate that better guidance is needed to improve the postoperative disposition and long-term care of this vulnerable patient population.
Congenitally Fused Cervical Spine Is Associated With Adjacent-Level Degeneration in the Absence of Cervical Spine Surgery
Authors: Friedman Gabriel N. , Grannan Benjamin L. , Zinzuwadia Aniket , Williams Ziv M. , Coumans Jean-Valery 
Published: March 2023

BACKGROUND:
Cervical fusion surgery is associated with adjacent-level degeneration, but surgical and technical factors are difficult to dissociate from the mechanical effects of the fusion itself.

OBJECTIVE:
To determine the effect of fusion on adjacent-level degeneration in unoperated patients using a cohort of patients with congenitally fused cervical vertebrae.

METHODS:
We identified 96 patients with incidental single-level cervical congenital fusion on computed tomography imaging. We compared these patients to an age-matched control cohort of 80 patients without congenital fusion. We quantified adjacent-level degeneration through direct measurements of intervertebral disk parameters as well as the validated Kellgren & Lawrence classification scale for cervical disk degeneration. Ordinal logistic regression and 2-way analysis of variance testing were performed to correlate extent of degeneration with the congenitally fused segment.

RESULTS:
Nine hundred fifty-five motion segments were analyzed. The numbers of patients with C2-3, C3-4, C4-5, C5-6, and C6-7 congenitally fused segments were 47, 11, 11, 17, and 9, respectively. We found that patients with congenital fusion at C4-C5 and C5-C6 had a significantly greater extent of degeneration at adjacent levels compared with the degree of degeneration at the same levels in control patients and in patients with congenital fusion at other cervical levels, even while controlling for expected degeneration and age.

CONCLUSION:
Taken together, our data suggest that congenitally fused cervical spinal segments at C4-C5 and C5-C6 are associated with adjacent-level degeneration independent of fixation instrumentation. This study design removes surgical factors that might contribute to adjacent-level degeneration.
Epidermal growth factor receptor signaling protects epithelia from morphogenetic instability and tissue damage in Drosophila
Authors: Yoshida Kentaro , Hayashi Shigeo 
Published: March 2023

ABSTRACT
Dying cells in the epithelia communicate with neighboring cells to initiate coordinated cell removal to maintain epithelial integrity. Naturally occurring apoptotic cells are mostly extruded basally and engulfed by macrophages. Here, we have investigated the role of Epidermal growth factor (EGF) receptor (EGFR) signaling in the maintenance of epithelial homeostasis. In Drosophila embryos, epithelial tissues undergoing groove formation preferentially enhanced extracellular signal-regulated kinase (ERK) signaling. In EGFR mutant embryos at stage 11, sporadic apical cell extrusion in the head initiates a cascade of apical extrusions of apoptotic and non-apoptotic cells that sweeps the entire ventral body wall. Here, we show that this process is apoptosis dependent, and clustered apoptosis, groove formation, and wounding sensitize EGFR mutant epithelia to initiate massive tissue disintegration. We further show that tissue detachment from the vitelline membrane, which frequently occurs during morphogenetic processes, is a key trigger for the EGFR mutant phenotype. These findings indicate that, in addition to cell survival, EGFR plays a role in maintaining epithelial integrity, which is essential for protecting tissues from transient instability caused by morphogenetic movement and damage.
Reliability of the 44-question Home Fall Hazard Assessment Tool and personal characteristics associated with home hazards among the Thai elderly
Authors: Wittayapun Yuwadee , Nawarat Jiraphat , Lapmanee Sarawut , Mackenzie Lynette , Lektip Charupa 
Published: March 2023

Background: The 44-question Thai Home Fall Hazard Assessment Tool (Thai-HFHAT) was developed to assist healthcare professionals in identifying the risk of falls among community-dwelling elderly from their home environment. However, the reliability of this tool has not been studied. This study aimed to examine the reliability of the 44-question Thai-HFHAT and determine the personal characteristics associated with home hazards. Methods: A descriptive cross-sectional study design was used to evaluate interrater reliability. The participants in this study were 51 elderly people from various types of Thai houses: a one-story elevated house, a one-story non-elevated house, and a house with two or more floors, 51 caregivers of elderly patients, and 5 village health volunteers (VHV). A prospective design was used to evaluate test-retest reliability with older people at different times in their homes. All participants answered 44 Thai-HFHAT questions to determine inter-rater and test-retest reliabilities. The reliabilities were analyzed using an intra-class correlation coefficient (ICC). Personal characteristics including sex, occupation, and education were used to identify the factors affecting home hazards, and linear regression was used to analyze. Results: The ICC of inter-rater reliability of the 44-question Thai-HFHAT was 0.74 (95% CI: 0.57-0.84) and the test-retest reliability was 0.80 (95% CI: 0.64-0.88) for the elderly, 0.80 (95% CI: 0.65-0.89) for the caregivers and 0.70 (95% CI: 0.477-0.83) for the VHV. Personal business career and education level grades 1-3 are less than 0.05, which showed these factors had a significant relationship with the 44-question Thai-HFHAT score as the dependent variable. Conclusions: The 44-question Thai-HFHAT is suitable for home hazard assessment among the elderly in Thailand. Further studies are needed to investigate changes in the house environment after using the 44-question Thai-HFHAT to determine which changes can reduce fall risk.
The effect of Vitamin D levels on the course of COVID-19 in hospitalized patients – a 1-year prospective cohort study
Authors: Siuka Darko , Saletinger Rajko , Uršič Jure , Jevnikar Kristina , Janša Rado , Štubljar David , Osredkar Joško 
Published: March 2023

Background: The aim of the current study was to assess the patients with COVID-19 and the impact of vitamin D supplementation on the course of COVID-19. Methods: This prospective cohort study included patients hospitalized due to COVID-19 between December 2020 and December 2021. Patients' demographic, clinical, and laboratory parameters were analysed. Results: 301 participants were enrolled in the study. 46 (15,3%) had moderate, and 162 (53,8%) had severe COVID-19. 14 (4,7%) patients died, and 30 (10,0%) were admitted to the ICU due to disease worsening. The majority needed oxygen therapy (n=224; 74,4%). Average vitamin 25(OH)D3 levels were below optimal at the admittance, and vitamin D deficiency was detected in 205 individuals. More male patients were suffering from vitamin D deficiency. Patients with the more severe disease showed lower levels of vitamin 25(OH)D3 in their blood. The most severe group of patients had more symptoms that lasted significantly longer with progressing disease severity. This group of patients also suffered from more deaths, ICU admissions, and treatments with dexamethasone, remdesivir, and oxygen. Conclusion: Patients with the severe course of COVID-19 were shown to have increased inflammatory parameters, increased mortality, and higher incidence of vitamin D deficiency. The results suggest that the vitamin D deficiency might represent a significant risk factor for a severe course of COVID-19.
Branch-Price-and-Cut-Based Solution of Order Batching Problems
Authors: Wahlen Julia , Gschwind Timo 
Published: March 2023

Given a set of customer orders each comprising one or more individual items to be picked, the order batching problem (OBP) in warehousing consists of designing a set of picking batches such that each customer order is assigned to exactly one batch, all batches satisfy the capacity restriction of the pickers, and the total distance traveled by the pickers is minimal. In order to collect the items of a batch, the pickers traverse the warehouse using a predefined routing strategy. We propose a branch-price-and-cut (BPC) algorithm for the exact solution of the OBP investigating the routing strategies traversal, return, midpoint, largest gap, combined, and optimal. The column-generation pricing problem is modeled as a shortest path problem with resource constraints (SPPRC) that can be adapted to handle the implications from nonrobust valid inequalities and branching decisions. The SPPRC pricing problem is solved by means of an effective labeling algorithm that relies on strong completion bounds. Capacity cuts and subset-row cuts are used to strengthen the lower bounds. Furthermore, we derive two BPC-based heuristics to identify high-quality solutions in short computation times. Extensive computational results demonstrate the effectiveness of the proposed methods. The BPC is faster by two orders of magnitude compared with the state-of-the-art exact approach and can solve to optimality hundreds of instances that were previously unsolved. The BPC-based heuristics are able to significantly improve the gaps reported for the state-of-the-art heuristic and provide hundreds of new best-known solutions. Funding: This research was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Grant 418727865]. This support is gratefully acknowledged. Supplemental Material: The e-companion is available at https://doi.org/10.1287/trsc.2023.1198 .
Iron supplementation for iron-deficiency anaemia
Authors: McDonald Elissa M , Mousa Sara , Ram Felix S F 
Published: March 2023

Background: In recent years, iron supplementation has increased significantly because of the damaging systemic effects of iron deficiency anaemia (IDA) being reported. The standard first-line therapy is oral iron tablets, with over 70% of recipients experiencing gastrointestinal adverse effects. Methods: This recent review of high-quality literature compares the effectiveness and adverse effects of tablet and liquid forms of iron supplementation in patients with IDA. Findings: The evidence to date indicates that both forms of iron supplementation are equally effective. However, the literature consistently and strongly supports the use of the liquid form of iron supplementation (ferrous sulfate) over the tablet form (ferrous sulphate or ferrous fumarate) in terms of adverse effects. Conclusions: Healthcare professionals should consider recommending the use of liquid iron formulation for the management of IDA and switch patients to this form if they experience gastrointestinal adverse effects. This may help to effectively manage IDA.
Development and Validation of a Concept Inventory for Interpreting Kinematics Graphs in the Tanzanian Context
Authors: Mbwile Beni , Ntivuguruzwa Celestin , Mashood K. K. 
Published: March 2023

<p style="text-align: justify;">This paper discusses the development and validation of a concept inventory for interpreting kinematics graphs in the Tanzanian context. The study involved 61 participants comprising physics pre-service teachers, secondary school teachers, diploma college tutors, and a university lecturer from Tanzania. We developed 25 multiple-choice questions for interpreting kinematics graphs. The different steps in the development process used are selecting the topic, setting objectives, constructing questions, validating questions, and reliability testing. We carried out descriptive and inferential statistical analysis by using Statistical Package for Social Science (SPSS) version 22 followed by item analysis for pre-and post-piloting. Findings revealed normal distribution scores with a mean and standard deviation of 39.28±10.893 for pre-piloting and 40.16±8.08 for post-piloting. It also revealed no significant difference between pre-and post-piloting results with a p-value of 0.414. In addition, correlation coefficients for test re-test reliability were .783 and .878 for single and average measures respectively. Moreover, item analysis in terms of difficulty index, discrimination index, and distractor efficiency agreed with the published standards. Based on these findings, the study recommends the use of developed and validated kinematics graphs concept inventory by physics educators in both research and classroom instructions in the Tanzanian context.</p>