bluuebunny/crossref_metadata_2025_split huggingface dataset:
Should I Stay or Should I Go (Later)? Teacher Intentions and Turnover in Low-Performing Schools and Districts before and during the COVID-19 Pandemic
Authors: Harbatkin Erica , Nguyen Tuan D. , Strunk Katharine O. , Burns Jason , Moran Alex J. 
Published: January 2025

Abstract
Teacher turnover is a perennial concern, especially in low-performing, high-poverty schools. While districts and schools may try to anticipate and mitigate turnover by surveying teachers about their future plans, existing research on whether teacher-reported intent is predictive of actual turnover behavior is mixed. Using unique survey data from teachers in 35 low-performing, high-poverty districts in Michigan linked at the teacher level to statewide administrative data, we are able to measure turnover behavior one, two, and three years following reported intent. We find that intent is a significant predictor of turnover and becomes increasingly predictive over time. We also find organizational commitment and school organizational conditions are important factors in teachers' intent and, to a lesser degree, actual turnover behavior.
How the Engagement of High-Profile Partisan Officials Affects Education Politics, Public Opinion, and Polarization
Authors: Houston David M. , Barone Alyssa 
Published: January 2025

Abstract
What happens to public opinion when prominent partisan officials intervene in education policy debates? We analyzed the results of 18 survey experiments conducted between 2009 and 2021 with nationally representative samples of U.S. adults. In each experiment, some respondents were randomly assigned to receive the current U.S. president's position on a specific education policy before all respondents were asked to indicate their support or opposition to that policy. Our results indicated that the engagement of high-profile partisan officials typically did little to move public opinion in the direction of the cue-giver's preferred policies. Instead, the chief consequence was increased polarization among the public along partisan lines. A key exception applied to endorsements of policies that diverged from the traditional position of the cue-giver's own party, which tended to shift aggregate public opinion modestly in favor of those policies. Such cross-party cues also had nontrivial de-polarizing consequences.
The impact of free-roaming dogs on lemurs in Madagascar: a decade of research and intervention
Authors: Valenta Kim , Rajaonarivelo Tsiky , Ferreira Angelique , Raharinirina Ange , Rafaliarison Radoniaina R. , Farris Alisha , Watson Jonas M. , deFrance Susan , Mayo Dominic , Filla Caitlynn , Ross Abigail , Bornbusch Sally L. , Satishchandran Siddharth , Kelly Thomas , Levy Julie K. , Randriana Zoavina , Farris Zach J. 
Published: January 2025

Abstract
Lemurs are the most endangered group of mammals on earth, and invasive species, including domestic dogs, are considered to be the second greatest threat to biodiversity after habitat loss. Here, we describe and summarize the challenges and results of a decade of research aimed at understanding the impact of dogs on lemurs, and efforts to humanely reduce dog populations in protected areas in Madagascar, to reduce their impact on lemurs and other wildlife, via the non-profit the Mad Dog Initiative. We have found that free-roaming domestic dog populations living in and around Madagascar’s protected areas both predate and displace native wildlife, and that the presence of dogs in forests drives a reduction of wildlife in forests. Additionally, dogs vector a number of pathogens that can have lethal consequences for lemur populations, as well as serving as important vectors of anti-microbial resistance. We propose several future directions for research, outreach, and capacity building in Madagascar and other low and middle income countries aimed at better quantifying the threat of domestic species on wildlife, and mitigating its impact.
Current concepts of high intensity interval training: a clinical commentary
Authors: Bidhuri D. , Kalra S. , Saher T. , Parveen A. , Ajmera P. , Miraj M. 
Published: January 2025

Abstract
Regular exercise produces a variety of physiological changes that improve exercise capacity and health, regardless of age, gender, or chronic illness status. Despite widespread physical inactivity due to time restrictions, High-Intensity Interval Training (HIIT) has evolved as a popular and time-saving strategy for strenuous exercise that improves physical fitness by increasing maximum oxygen uptake (VO2max) and muscle power. HIIT, which consists of brief bursts of intense activity at or near peak effort interspersed with intervals of rest or low-intensity exercise, causes a variety of physiological changes that improve exercise capacity and metabolic health in both clinical and healthy populations. Given the expanding scientific understanding and broad use of HIIT, this clinical commentary seeks to thoroughly investigate its definition, parameters, scientific foundations, multifarious benefits, and evidence across varied groups and situations.
Adapting Responsibility to Protect (r2p) for a Multipolar World: Sovereignty, Intervention, and Veto Power
Authors: Cüre Fatih 
Published: January 2025

Abstract
This article discusses how the Responsibility to Protect (r2p) doctrine can evolve within a shifting global order, marked by multipolarity and declining liberal norms. It identifies three main challenges: sovereignty, selective implementation, and the use of veto power. Although r2p frames sovereignty as a responsibility, resistance from non-Western powers like China and Russia underscores the need to integrate diverse perspectives on state sovereignty, reflecting these countries’ growing influence in international norms. This resistance has exposed the fragile consensus around r2p within the United Nations, as inconsistent application has led to scepticism and diminished credibility. To sustain r2p’s relevance, the article proposes adapting the doctrine to align with geopolitical realities, advocating a nuanced approach that respects varied views on intervention while encouraging accountability in veto use for atrocity prevention. In doing so, it offers pathways for r2p to retain its humanitarian goals amid the complexities of a multipolar world.
Selective breeding of heat-tolerant black soldier fly (Hermetia illucens) larvae: gut microbial shifts and transcriptional patterns
Authors: Feng X. , Huang Z. , Ahmad S. , Ma C. , Zhu J. , Li K. , Peng G. , Tettamanti G. , Hu W. , Xu H. , Tian L. 
Published: January 2025

Abstract
The black soldier fly larvae (BSFL) have garnered great attention for their potential role in converting organic waste into high-quality insect proteins, providing valuable feed components for animal production and highly enriched organic manure for crop production. However, environmental factors such as high temperatures can compromise their productivity. To address this, we conducted selective breeding of BSFL at 40 °C, and the bred group was improved with higher body weight, survival rates, and substrate reduction after nine generations of breeding. Notably, the gut microbiota of the heat-tolerant colony was highly represented by the bacteria belonging to Proteobacteria, Firmicutes, and Actinobacteria, while the Bacteroidetes phyla were decreased. Transcriptomic analysis revealed that the upregulated genes in 40 °C bred groups were primarily involved in biological processes such as Spliceosome, FoxO signaling pathway, longevity regulating pathways, Drug metabolism, and Xenobiotic metabolism via cytochrome P450. These findings provide a detailed understanding of the molecular mechanisms underlying BSFL’s adaptation to heat stress, facilitating future industrial application advancements.
One new species and one new record of family Photidae Boeck, 1871 (Amphipoda: Senticaudata) from Gujarat, India
Authors: THACKER DIMPLE , MYERS ALAN A. , TRIVEDI JIGNESHKUMAR N. 
Published: January 2025

The present study was conducted based on the amphipod specimens collected from the Veraval coast of Gujarat state, India. From the collection, 2 species of family Photidae Boeck, 1871 were identified: Audulla sindhu sp. nov. and Latigammaropsis photisimilis (Ruffo, 1969). Audulla sindhu sp. nov. can be differentiated from its only congener Audulla chelifera Chevreux, 1901 by having gnathopod 2 propodus comparatively longer and slender and presence of uropod 1 inter-ramus spur. Another species Latigammaropsis photisimilis (Ruffo, 1969) is first time reported from India in the study which was only reported from Red Sea (Ruffo, 1969) till now.
Exploring Fagonia cretica and Berberis lycium as α-Amylase Inhibitors: Potential Therapeutic Strategies for Diabetes Mellitus Investigated Through In Vitro and In Silico Approaches
Authors: Chen Yan-Kun , Ahmad Imtiaz , Rahman Noor , Shafiullah  , Khan Haroon , Rastrelli Luca , Alam Said , Jardan Yousef A. Bin , Bourhia Mohammed , Jiang Changan 
Published: January 2025

Background: Growing diabetes prevalence prompts investigation into plant-derived compounds’ potential to inhibit α-amylase, offering novel therapeutic avenues for treating diabetes mellitus (DM). Purpose: In the current study, ethanolic and methanolic extracts of Fagonia cretica and Berberis lycium were evaluated against α-amylase. Methods: The inhibitory activity of ethanolic and methanolic extracts was analyzed based on their IC50 values. An in vitro activity of α-amylase inhibition was performed, followed by molecular docking and molecular dynamics (MD) simulation of selected compounds. Results: Results indicated that F. cretica and B. lycium extracts have strong inhibitory effects against α α-amylase. In ethanolic and methanolic extracts, the methanolic B. lycium extract was the most potent with an IC50 value of 2.10 µg/mL; the ethanolic B. lycium, ethanolic, and methanolic F. cretica extracts also showed significant anti-α-amylase effects with IC50 values of 3.88, 4.09, and 7.26 µg/mL, respectively. Further, a total of 36 phytochemicals were docked against the α-amylase enzyme to explore the binding mode of these phytochemicals. Docking results confirmed that most of the phytochemicals accommodate well in the active site of α-amylase and made strong interactions compared to the standard drug acarbose. Also, the MD simulation results confirmed that both phytochemicals revealed greater stability than the standard acarbose. Conclusion: Based on these results, we concluded that the extract showed good effectiveness and further in vivo study is needed to manage DM.
Physicians’ and patients’ perceived risks of chronic pain medication and co-medications in Quebec, Canada: a cross-sectional study
Authors: De Clifford-Faugère Gwenaëlle , Lacasse Anaïs , Nguena Nguefack Hermine Lore , Godbout-Parent Marimée , Boulanger Aline , Julien Nancy 
Published: January 2025

Abstract

Background
The risks associated with medications and co-medications for chronic pain (CP) can influence a physician’s choice of drugs and dosages, as well as a patient’s adherence to the medication. High-quality care requires patients to participate in medication decisions. This study aimed to compare perceived risks of medications and co-medications between physicians and persons living with CP.

Methods
This cross-sectional survey conducted in Quebec, Canada, included 83 physicians (snowball sampling) and 141 persons living with CP (convenience sampling). Perceived risks of adverse drug reaction of pain medications and co-medications were assessed using 0–10 numerical scales (0 = no risk, 10 = very high risk). An arbitrary cutoff point of 2-points was used to ease the interpretation of our data. Physicians scored the 36 medication subclasses of the Medication Quantification Scale 4.0 (MQS 4.0) through an online survey, while CP patients scored the medication subclasses they had taken in the last three months through telephone interviews.

Results
Persons living with CP consistently perceived lower risks of adverse drug reaction compared to physicians. For eight subclasses, the difference in the mean perceived risk score was > 2 points and statistically significant (p < 0.05): non-specific oral NSAIDs, acetaminophen in combination with an opioid, short-acting opioids, long-acting opioids, tricyclic antidepressants, antipsychotics, benzodiazepines, and medical cannabis.

Conclusions
Divergent risk perceptions between physicians and patients underscore the necessity of facilitating a more extensive discussion on medications and co-medications risks to empower patients to make informed decisions and participate in shared decision-making regarding their treatments.
Treatment of gingival recession with vestibular incision subperiosteal tunnel access and advanced platelet-rich fibrin
Authors: Abdelhaleem Marwa , Saleh Wafaa , Elmeadawy Samah 
Published: January 2025

Abstract

Objectives
The current literature about the effect of advanced platelet rich fibrin(A-PRF) with vestibular incision subperiosteal tunnel access (VISTA) technique in treating gingival recession is scarce. Therefore, the aim of the current randomized clinical trial is to evaluate the effect of A-PRF with VISTA technique in the treatment of Cairo class 1 gingival recession (RT1).

Methods
Twenty-four patients who met the eligibility criteria were randomly allocated into two groups. VISTA + A-PRF was the treatment of the study group, while VISTA + collagen matrix was performed for the control group. The clinical outcomes were assessed by a single-blind assessor at baseline, three months, and six months. They were divided into primary and secondary outcomes. The primary outcomes included recession depth (RD), recession width (RW), gingival thickness (GT), mean of root coverage % (MRC%), and width of attached gingiva (WAG) while the secondary outcome included clinical attachment level (CAL).

Results
The primary outcomes analysis demonstrated statistically significant improvements in RD, RW, MRC%, GT, and WAG after 3 and 6 months in both groups (p < 0.001). However, the study group demonstrated a significantly greater improvement than the control group in RD, RW, and MRC%. No significant differences were observed between the two groups regarding GT and WAG.

Conclusions
Both treatment approaches were effective in the treating of RT1 adjacent gingival recessions. A-PRF showed promising results compared to collagen matrix.

Trial registration
The current randomized clinical trial was registered at ClinicalTrials.gov (Registration number: NCT06357351) and it was released on 10/04/2024.
Signal integrator function of CXXC5 in Cancer
Authors: An Zihao , Wang Jiepu , Li Chengzuo , Tang Chao 
Published: January 2025

Abstract
CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. In this article, we correspondingly describe the composition of the ZF-CXXC family, emphatically introducing the features of the CXXC5 gene and protein, review the role of CXXC5 in cellular signaling networks, the physiological and pathological processes associated with CXXC5 dysregulation, and particularly focus on the correlation between CXXC5 and cancers. Finally, we summarize the current therapies targeting CXXC5 and their potential applications, and discuss the intriguing findings from current studies, and the opportunities and challenges in future.

Graphical Abstract
Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease
Authors: Rubino Elisa , Italia Maria , Giorgio Elisa , Boschi Silvia , Dimartino Paola , Pippucci Tommaso , Roveta Fausto , Cambria Clara Maria , Elia Gabriella , Marcinnò Andrea , Gallone Salvatore , Rogaeva Ekaterina , Antonucci Flavia , Brusco Alfredo , Gardoni Fabrizio , Rainero Innocenzo 
Published: January 2025

Abstract

Background
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with both genetic and environmental factors contributing to its pathogenesis. While early-onset AD has well-established genetic determinants, the genetic basis for late-onset AD remains less clear. This study investigates a large Italian family with late-onset autosomal dominant AD, identifying a novel rare missense variant in GRIN2C gene associated with the disease, and evaluates the functional impact of this variant.

Methods
Affected and unaffected members from a Northern Italian family were included. Genomic DNA from family members was extracted and initially screened for pathogenic mutations in APP, PSEN1, and PSEN2, and screened for 77 genes associated with neurodegenerative conditions using NeuroX array assay. Exome sequencing was performed on three affected individuals and two healthy relatives. Bioinformatics analyses were conducted. Functional analysis was performed using primary neuronal cultures, and the impact of the variant was assessed through immunocytochemistry and electrophysiology.

Results
Pathogenic variants were not identified in APP, PSEN1, or PSEN2, nor in the 77 genes in NeuroX array assay. Exome Sequencing revealed the c.3215C > T p.(A1072V) variant in GRIN2C gene (NM 000835.6), encoding for the glutamate ionotropic receptor N-methyl-D-aspartate receptor (NMDA) type subunit 2C (GluN2C). This variant segregated in 6 available AD patients in the family and was absent in 9 healthy relatives. Primary rat hippocampal neurons overexpressing GluN2CA1072V showed an increase in NMDAR-induced currents, suggesting altered glutamatergic transmission. Surface expression assays demonstrated an elevated surface/total ratio of the mutant GluN2C, correlating with the increased NMDAR current. Additionally, immunocytochemistry revealed in neurons expressing the mutant variant a reduced colocalization between the GluN2C subunit and 14-3-3 proteins, which are known to facilitate membrane trafficking of NMDARs.

Discussion
We identified a rare missense variant in GRIN2C associated with late-onset autosomal dominant Alzheimer's disease. These findings highlight the role of GluN2C-containing NMDARs in glutamatergic signaling and their potential contribution to AD pathogenesis.
Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study
Authors: Tian Youli , Li Jintong , Jin Minggen , Piao YiHua , Sheng Jisheng , Mei Zhixiong , Cui Qingsong , Li Lilin 
Published: January 2025

Abstract

Background
Invasive procedures and environmental factors in the intensive care unit (ICU) may cause anxiety and discomfort in patients, who often require sedation therapy. The aim of this study was to assess the safety of remimazolam tosilate for procedural sedation in ICU patients receiving mechanical ventilation following endotracheal intubation. Eighty patients from a single centre were randomly assigned to either the propofol group or the remimazolam group. Blood tests were conducted to evaluate changes in lactate, blood lipids, liver and kidney function, and inflammatory markers, and patients’ vital signs were observed over several periods. This study compared the incidence of delirium, the impact on liver and kidney function, circulatory effects, and changes in blood lipids between the two groups. These findings have optimised the selection of medications, providing ICU patients with more options for sedation therapy.

Methods
In this single-centre randomised controlled trial, intubated patients were randomly assigned to the remimazolam group or the propofol group. Under the same analgesic regimen, the two groups received remimazolam and propofol for procedural sedation.

Results
Our primary outcome was the mean arterial pressure (MAP), which significantly differed on Days 4 and 7 (P = 0.021, control group vs. experimental group = 85.23 ± 11.24 vs. 94.36 ± 13.18, P = 0.023, 83.55 ± 8.94 vs. 92.66 ± 7.02). With respect to liver and kidney function, the ∆AST value in the remimazolam group was significantly lower than that in the control group on Day 7 (P = 0.023). There were significant differences in triglyceride (TG) levels on Days 4 and 7 (P = 0.020) and in the ∆LDL on Day 7 (P = 0.027). Furthermore, the rates of dyslipidaemia and delirium in the remimazolam group were lower than those in the propofol group (85.0%, n = 40 vs. 90.0%, n = 40; 27.5%, n = 40 vs. 55%, n = 40).

Conclusion
Remimazolam is a novel benzodiazepine that has demonstrated promising applications in general anaesthesia and procedural sedation; however, its use in ICU sedation is still in the early stages of research. Current evidence suggests that remimazolam is a safe sedative that is particularly well suited for patients with haemodynamic instability. Large sample-size randomised clinical trials are warranted.
Anti-allergic effect of 5,7-dihydroxy-4-methylcoumarin in IgE-mediated RBL-2H3 cells and PCA murine model
Authors: Gwon Sugeun , Shin Seong-Ah , Kim Moonsu , Moon Sun Young , Choi Seyeon , Kim Minji , Lee Jun Hyuck , Park Hyun Ho , Lee Chang Sup 
Published: January 2025

Abstract
Allergy is an immune-mediated disorder characterized by an exaggerated response of the immune system to non-hazardous substances, resulting in allergic symptoms such as rash, itching, and runny nose. Current therapeutic interventions include antihistamines and steroids; however, they induce several side effects. Although 5,7-dihydroxy-4-methylcoumarin, a phytochemical derivative, has been demonstrated to exhibit antioxidant, anti-apoptotic, and anti-aggregatory effects, its anti-allergic properties and underlying molecular mechanisms remain elusive. Therefore, this study was conducted to investigate the anti-allergic effects of 5,7-dihydroxy-4-methylcoumarin in two experimental models: rat basophilic leukemia-2H3 cells sensitized using dinitrophenyl-specific immunoglobulin E (IgE)/human serum albumin and a passive cutaneous anaphylaxis (PCA) murine model. Our findings demonstrated that 5,7-dihydroxy-4-methylcoumarin reduced the release of histamine and β-hexosaminidase and downregulated the mRNA expression of allergic-inflammatory cytokines, such as interleukin (IL)-4, IL-13, and tumor necrosis factor-alpha, as well as the inflammatory enzyme cyclooxygenase-2. Furthermore, 5,7-dihydroxy-4-methylcoumarin reduced the phosphorylation of mitogen-activated protein kinases such as extracellular signal-regulated kinase and p38, as well as protein kinase B. In vivo, 5,7-dihydroxy-4-methylcoumarin reduced PCA reaction, as evidenced by reduced Evans blue dye extravasation in IgE-mediated local allergic responses. Collectively, these results suggest that 5,7-dihydroxy-4-methylcoumarin holds promise as a novel candidate for the development of anti-allergic drugs.