bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reporting Findings from an Exploratory Study of Social Workers’ Perceptions about autism Training
Authors: Heslop Philip , Bushell Matthew 
Published: April 2023

Abstract
There is considerable literature on autism but a paucity of literature on social work with autistic people. This is surprising when autistic people may be overrepresented in the populations that social workers assess and support. This article reports the findings from a qualitative study exploring social workers’ perceptions of training needs about autism through two focus groups involving social workers. Social workers frequently engage with autistic people, either as practitioners in specialist teams but more frequently through generic adult and/or childcare services; therefore, awareness of autism is important. Autism is complex because it is sometimes hidden, which is exacerbated when autistic people may mask and camouflage their autism and any difficulties they experience. Data from the focus groups were thematically analysed to identify themes that highlight how social workers benefit from training about autism and how to work with autistic people, which includes training from autistic people and others with lived experience. The authors of this article represent different perspectives: the first author is a social work educator with over three decades’ practice and personal autism experience, and the second author is a social work manager and practitioner in a specialist service.
Unlocked doors: the trans glitch in Kitty Horrorshow’s Anatomy
Authors: Prevas Christine 
Published: April 2023

Abstract
This article explores the glitch as a trans mechanic of speculation in Kitty Horrorshow’s (2016) video game Anatomy. Through the glitch, Anatomy rewrites the “walking simulator” in favor of a non-linear form of movement that relies on gaps and breaks in the structure of the game. Drawing on scholarship in trans studies including Eva Hayward’s work on the scar as a site of trans possibility and Lucas Crawford’s examination of the relationship between architecture and trans subjectivity, I read Anatomy as one ludic form of trans worldmaking which unsettles the relationship between the trans body and the space of the house, and the relationship between the player and the act of play, invoking a trans ethos of indeterminacy that rejects coherent narratives of progression and legibility in favor of the refusal and possibility of the glitch.
How incubation temperature affects hatchling performance in reptiles: an integrative insight based on plasticity in metabolic enzyme
Authors: Wu Dan-Yang , Han Xing-Zhi , Li Teng , Sun Bao-Jun , Qin Xiao-Yan 
Published: April 2023

Abstract
Evaluating the effects of temperature variations on animals plays an important role in understanding the threat of climate warming. The effects of developmental temperature on offspring performance are critical in evaluating the effects of warming temperatures on the fitness of oviparous species, but the physiological and biochemical basis of this developmental plasticity is largely unknown. In this study, we incubated eggs of the turtle Pelodiscus sinensis at low (24 °C), medium (28 °C), and high (32 °C) temperatures, and evaluated the effects of developmental temperature on offspring fitness, and metabolic enzymes in the neck and limb muscles of hatchlings. The hatchlings from eggs incubated at the medium temperature showed better fitness-related performance (righting response and swimming capacity) and higher activities of metabolic enzymes (hexokinase, HK; lactate dehydrogenase, LDH) than hatchlings from the eggs incubated at high or low temperatures. In addition, the swimming speed and righting response were significantly correlated with the HK activities in limb (swimming speed) and neck (righting response) muscles, suggesting that the developmental plasticity of energy metabolic pathway might play a role in determining the way incubation temperature affects offspring phenotypes. Integrating the fitness-related performance and the activities of metabolic enzymes, we predict that the P. sinensis from high latitude would not face the detrimental effects of climate warming until the average nest temperatures reach 32 °C.
Prognostic implications of left ventricular systolic dysfunction in patients with spontaneous coronary artery dissection
Authors: Díez-Villanueva Pablo , García-Guimarães Marcos , Sanz-Ruiz Ricardo , Sabaté Manel , Macaya Fernando , Roura Gerard , Jimenez-Kockar Marcelo , Flores-Ríos Xacobe , Moreu Jose , Fuertes-Ferre Georgina , Jimenez-Valero Santiago , Tizón Helena , Nogales Juan Manuel , Velázquez Maite , Lozano Íñigo , Avanzas Pablo , Salamanca Jorge , Bastante Teresa , Alfonso Fernando 
Published: April 2023

Abstract

Aims
Spontaneous coronary artery dissection (SCAD) is a relatively infrequent cause of acute coronary syndrome. Clinical features, angiographic findings, management, and outcomes of SCAD patients who present reduced left ventricular ejection fraction (LVEF) remain unknown.

Methods and results
The Spanish multicentre prospective SCAD registry (NCT03607981), included 389 consecutive patients with SCAD. In 348 of these patients, LVEF could be assessed by echocardiography during the index admission. Characteristics and outcomes of patients with preserved LVEF (LVEF ≥50%, n = 295, 85%) were compared with those with reduced LVEF (LVEF &lt;50%, n = 53, 15%). Mean age was 54 years and 90% of patients in both groups were women. The most frequent clinical presentation in patients with reduced LVEF was ST-segment elevation myocardial infarction (STEMI) (62% vs. 36%, P &lt; 0.001), especially anterior STEMI. Proximal coronary segment and multi-segment involvement were also significantly more frequent in these patients. No differences were found on initial revascularization between groups. Patients with reduced LVEF significantly received more often neurohormonal antagonist therapy, and less frequently aspirin. In-hospital events were more frequent in these patients (13% vs. 5%, P = 0.01), with higher rates of death, cardiogenic shock, ventricular arrhythmia, and stroke. During a median follow-up of 28 months, the occurrence of a combined adverse event did not statistically differ between the two groups (19% vs. 12%, P = 0.13). However, patients with reduced LVEF had higher mortality (9% vs. 0.7%, P &lt; 0.001) and readmission rates for heart failure (HF) (4% vs. 0.3%, P = 0.01).

Conclusion
Patients with SCAD and reduced LVEF show differences in clinical characteristics and angiographic findings compared with SCAD patients with preserved LVEF. Although these patients receive specific medications at discharge, they had higher mortality and readmission rates for HF during follow-up.
At Long Last: Short, All-Oral Regimens for Multidrug-Resistant Tuberculosis in the United States
Authors: Sinha Pranay , Jacobson Karen R , Horsburgh C Robert , Acuña-Villaorduña Carlos 
Published: April 2023

Abstract
Multidrug-resistant tuberculosis (MDR-TB) has historically required longer treatment regimens that were associated with higher unfavorable outcomes and side effects rates compared with drug susceptible TB (DS-TB). During the last decade, several studies conducted mostly in high-incidence settings have shown that MDR-TB can be successfully treated using all-oral shorter regimens of 6- to 9-month duration. In this article, we review the evolution of MDR-TB treatment from the early long regimens with injectables agents (IAs), followed by the shorter regimens with IA, to the groundbreaking, all-oral, 6- to 9-month regimens. Finally, we propose a framework for implementation of the shorter all-oral regimens in the United States.
Cell-of-origin–specific proteomics of extracellular vesicles
Authors: Kehrloesser Sebastian , Cast Oliver , Elliott Thomas S , Ernst Russell J , Machel Anne C , Chen Jia-Xuan , Chin Jason W , Miller Martin L 
Published: April 2023

Abstract
The ability to assign cellular origin to low-abundance secreted factors in extracellular vesicles (EVs) would greatly facilitate the analysis of paracrine-mediated signaling. Here, we report a method, named selective isolation of extracellular vesicles (SIEVE), which uses cell type-specific proteome labeling via stochastic orthogonal recoding of translation (SORT) to install bioorthogonal reactive groups into the proteins derived from the cells targeted for labeling. We establish the native purification of intact EVs from a target cell, via a bioorthogonal tetrazine ligation, leading to copurification of the largely unlabeled EV proteome from the same cell. SIEVE enables capture of EV proteins at levels comparable with those obtained by antibody-based methods, which capture all EVs regardless of cellular origin, and at levels 20× higher than direct capture of SORT-labeled proteins. Using proteomic analysis, we analyze nonlabeled cargo proteins of EVs and show that the enhanced sensitivity of SIEVE allows for unbiased and comprehensive analysis of EV proteins from subpopulations of cells as well as for cell-specific EV proteomics in complex coculture systems. SIEVE can be applied with high efficiency in a diverse range of existing model systems for cell–cell communication and has direct applications for cell-of-origin EV analysis and for protein biomarker discovery.
After-Action Reviews and the Big Black Hole of Improvement Processes
Authors: Hipple Natalie Kroovand , Hunter Benjamin D 
Published: April 2023

Abstract
University and campus public safety departments deal with a wide range of planned events and incidents from felonious crimes, chemical spills, and other emergent incidents to routine activities that require consistent reviews like commencement ceremonies. After-Action reviews (AARs) are a standard process in several industries including public safety, yet there is little empirical research when it comes to how AARs are applied to campus public safety entities and their outcomes. The Indiana University Public Safety Department (IUPS) reviewed 153 AAR reports, from 2017 through 2020, across seven Indiana University campuses and two academic centres. We highlight the key empirical findings from that review and how they influenced policy and practice at IUPS. We also highlight the role of the researcher–practitioner partnership in the process. We present lessons learned from the project along with suggestions for agencies interested in implementing a robust AAR process.
Parity versus Ignorance
Authors: Schulz Moritz 
Published: April 2023

AbstractWhy are hard decisions hard? According to the incomparabilists, hard choices are hard because the options cannot be compared. Proponents of parity hold that hard choices are hard because the options can be compared but only in terms of a fourth value relation—parity—in addition to the three standard relations: better, worse, and equally good. Others claim that hard choices are hard because it is vague (or indeterminate) how the options relate in terms of the three standard relations. Lastly, there is the epistemicist. For the epistemicist, hard choices are hard because one is irresolvably ignorant about how the options compare. In the debate about hard choices, epistemicism is often mentioned but rarely defended. The present paper is a contribution to closing this gap.
The role of the microbiome in rheumatoid arthritis: a review
Authors: Tsetseri Maria-Nefeli , Silman Alan J , Keene David J , Dakin Stephanie G 
Published: April 2023

AbstractThe close bidirectional relationship between the microbiome and the immune system is well supported, and a role of gut dysbiosis has been implied in many systemic autoimmune diseases. This review aims to provide a critical summary and appraisal of 6 murine studies and 16 clinical studies. The findings of the literature review suggest that gut dysbiosis precedes arthritis and that local intestinal inflammation leads to systemic inflammation in genetically predisposed individuals. However, the exact mechanism by which microorganisms provoke immune responses at distal sites remains to be elucidated. Although a characteristic RA microbiome was not identified, there were some common findings among studies: overabundance of Prevotella copri in early RA patients, and proliferation of the genus Collinsela and some Lactobacillus species. Three mechanisms by which microbiota might contribute to RA pathogenesis were proposed: inflammatory responses (P. copri and Lactobacillus), molecular mimicry (P. copri) and loss of intestinal barrier integrity (Collinsella). Larger longitudinal studies are required in order to shed light on the mechanisms involved and unravel the therapeutic potential of the microbiome, and clinical trials are needed to evaluate the safety and efficacy of the implied therapeutic interventions.
The impact of comorbidities on interleukin-17 inhibitor therapy in psoriatic arthritis: a Danish population-based cohort study
Authors: Petersen Magnus B , Hansen Rebekka L , Egeberg Alexander , Jørgensen Tanja S , Merola Joseph Frank , Coates Laura C , Kristensen Lars Erik 
Published: April 2023

Abstract

Objective
To investigate the influence of comorbidities on treatment response, disease activity and persistence with first-line IL-17 inhibitor (IL-17i) treatment in patients with PsA.

Methods
Patients were divided into three groups depending on the presence and/or severity of comorbidities using the Charlson Comorbidity Index (CCI). Groups were CCI 0: no comorbidities, CCI 1: one comorbidity and CCI ≥2: two or more comorbidities or one or more severe comorbidities. Outcomes in the groups were compared for treatment persistence, treatment response and disease activity.

Results
A higher CCI score was associated to an elevation in baseline CRP, swollen joint count and frequency of depression and/or anxiety. The median drug persistence in the groups were CCI 0: 1.8 years, CCI 1: 1.9 years and CCI ≥2: 1.5 years, but was not statistically significant to the CCI score. There were no significant differences in clinical response rates between the groups.

Conclusion
The presence of comorbidities was associated with increased baseline disease activity and frequency of depression and/or anxiety, but was not associated with shorter treatment persistence or lower clinical response rates in a cohort of 155 Danish patients with PsA treated with first-line IL-17i.
Are Carbon Emissions Associated with Stock Returns?
Authors: Aswani Jitendra , Raghunandan Aneesh , Rajgopal Shiva 
Published: April 2023

Abstract
An influential emerging literature documents strong correlations between carbon emissions and stock returns. We re-examine those data and conclude that these associations are driven by two factors. First, stock returns are correlated only with unscaled emissions estimated by the data vendor, but not with unscaled emissions actually disclosed by firms. Vendor-estimated emissions systematically differ from firm-disclosed emissions and are highly correlated with financial fundamentals, suggesting that prior findings primarily capture the association between such fundamentals and returns. Second, unscaled emissions, the variable typically used in academic literature, is correlated with stock returns but emissions intensity (emissions scaled by firm size), an equally important measure used in practice, is not. While unscaled emissions represent an important metric for society, we argue that, for individual firms, emissions intensity is an appropriate measurement choice to assess carbon performance. The associations between emissions and returns disappear after accounting for either of the issues above.
Brain Structure Measurements Predict Individualized Treatment Outcome of 12-Week Antipsychotic Monotherapies in First-episode Schizophrenia
Authors: Chen Ying , Cao Hengyi , Liu Shanming , Zhang Bo , Zhao Gaofeng , Zhang Zhuoqiu , Li Shuiying , Li Haiming , Yu Xin , Deng Hong 
Published: April 2023

Abstract

Background and Hypothesis
Early prediction of treatment response to antipsychotics in schizophrenia remains a challenge in clinical practice. This study aimed to investigate if brain morphometries including gray matter volume and cortical thickness could serve as potential predictive biomarkers in first-episode schizophrenia.

Study Design
Sixty-eight drug-naïve first-episode patients underwent baseline structural MRI scans and were subsequently randomized to receive a single antipsychotic throughout the first 12 weeks. Assessments for symptoms and social functioning were conducted by eight “core symptoms” selected from the Positive and Negative Syndrome Scale (PANSS-8) and the Personal and Social performance scale (PSP) multiple times during follow-ups. Treatment outcome was evaluated as subject-specific slope coefficients for PANSS-8 and PSP scores using linear mixed model. LASSO regression model were conducted to examine the performance of baseline gray matter volume and cortical thickness in prediction of individualized treatment outcome.

Study Results
The study showed that individual brain morphometries at baseline, especially the orbitofrontal, temporal and parietal cortex, pallidum and amygdala, significantly predicted 12-week treatment outcome of PANSS-8 (r[predicted vs observed] = 0.49, P = .001) and PSP (r[predicted vs observed] = 0.40, P = .003) in first-episode schizophrenia. Moreover, the gray matter volume performed better than cortical thickness in the prediction the symptom changes (P = .034), while cortical thickness outperformed gray matter volume in the prediction of outcome of social functioning (P = .029).

Conclusions
These findings provide initial evidence that brain morphometry have potential to be used as prognostic predictors for antipsychotic response in patients, encouraging the future investigation of the translational value of these measures in precision psychiatry.
A Genome Resource for 192 Verticillium dahliae Isolates Infecting Potatoes Across Canada
Authors: Arseneault Tanya , Lafond-Lapalme Joël , Gonzalez Chary Esteban Quinche , Jordan Katerina S. , Yevtushenko Dmytro , Barrett Ryan , Van der Heyden Hervé , Chen Dahu , Tenuta Mario , Mimee Benjamin 
Published: April 2023

Verticillium dahliae is an important soilborne pathogen causing Verticillium wilt. It is also the primary causal agent of potato early dying, a disease complex involving the root-lesion nematode. Here, we report the whole-genome sequencing of 192 isolates of V. dahliae originating from the major potato production areas across Canada. Our results yielded a resource of 277,010 genetic variations that will be useful for genetic analyses and revealed the presence of two major lineages, both present in all provinces but exhibiting differences in regional prevalence. [Formula: see text] Copyright © 2023 His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food Canada. This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Association of an Emergency Critical Care Program With Survival and Early Downgrade Among Critically Ill Medical Patients in the Emergency Department*
Authors: Mitarai Tsuyoshi , Gordon Alexandra June , Nudelman Matthew J. R. , Urdaneta Alfredo E. , Nesbitt Jason Lawrence , Niknam Kian , Graber-Naidich Anna , Wilson Jennifer G. , Kohn Michael A. 
Published: April 2023

OBJECTIVES:
To determine whether implementation of an Emergency Critical Care Program (ECCP) is associated with improved survival and early downgrade of critically ill medical patients in the emergency department (ED).

DESIGN:
Single-center, retrospective cohort study using ED-visit data between 2015 and 2019.

SETTING:
Tertiary academic medical center.

PATIENTS:
Adult medical patients presenting to the ED with a critical care admission order within 12 hours of arrival.

INTERVENTIONS:
Dedicated bedside critical care for medical ICU patients by an ED-based intensivist following initial resuscitation by the ED team.

MEASUREMENTS AND MAIN RESULTS:
Primary outcomes were inhospital mortality and the proportion of patients downgraded to non-ICU status while in the ED within 6 hours of the critical care admission order (ED downgrade <6 hr). A difference-in-differences (DiD) analysis compared the change in outcomes for patients arriving during ECCP hours (2 pm to midnight, weekdays) between the preintervention period (2015–2017) and the intervention period (2017–2019) to the change in outcomes for patients arriving during non-ECCP hours (all other hours). Adjustment for severity of illness was performed using the emergency critical care Sequential Organ Failure Assessment (eccSOFA) score. The primary cohort included 2,250 patients. The DiDs for the eccSOFA-adjusted inhospital mortality decreased by 6.0% (95% CI, –11.9 to –0.1) with largest difference in the intermediate illness severity group (DiD, –12.2%; 95% CI, –23.1 to –1.3). The increase in ED downgrade less than 6 hours was not statistically significant (DiD, 4.8%; 95% CI, –0.7 to 10.3%) except in the intermediate group (DiD, 8.8%; 95% CI, 0.2–17.4).

CONCLUSIONS:
The implementation of a novel ECCP was associated with a significant decrease in inhospital mortality among critically ill medical ED patients, with the greatest decrease observed in patients with intermediate severity of illness. Early ED downgrades also increased, but the difference was statistically significant only in the intermediate illness severity group.
Bismuth, esomeprazole, metronidazole, and minocycline or tetracycline as a first-line regimen for Helicobacter pylori eradication: A randomized controlled trial
Authors: Suo Baojun , Tian Xueli , Zhang Hua , Lu Haoping , Li Cailing , Zhang Yuxin , Ren Xinlu , Yao Xingyu , Zhou Liya , Song Zhiqiang 
Published: April 2023

Abstract

Background:
Given the general unavailability, common adverse effects and complicated administration of tetracycline, the clinical application of classic bismuth quadruple therapy (BQT) is greatly limited. Whether minocycline can replace tetracycline for Helicobacter pylori (H. pylori) eradication is unknown. We aimed to compare the eradication rate, safety, and compliance between minocycline- and tetracycline-containing BQT as first-line regimens.

Methods:
This randomized controlled trial was conducted on 434 naïve patients with H. pylori infection. The participants were randomly assigned to 14-day minocycline-containing BQT group (bismuth potassium citrate 110 mg q.i.d., esomeprazole 20 mg b.i.d., metronidazole 400 mg q.i.d., and minocycline 100 mg b.i.d.) and tetracycline-containing BQT group (bismuth potassium citrate/esomeprazole/metronidazole with doses same as above and tetracycline 500 mg q.i.d.). Safety and compliance were assessed within 3 days after eradication. Urea breath test was performed at 4–8 weeks after eradication to evaluate outcome. We used a noninferiority test to compare the eradication rates of the two groups. The intergroup differences were evaluated using Pearson chi-squared or Fisher's exact test for categorical variables and Student's t-test for continuous variables.

Results:
As for the eradication rates of minocycline- and tetracycline-containing BQT, the results of both intention-to-treat (ITT) and per-protocol (PP) analyses showed that the difference rate of lower limit of 95% confidence interval (CI) was >-10.0% (ITT analysis: 181/217 [83.4%] vs. 180/217 [82.9%], with a rate difference of 0.5% [-6.9% to 7.9%]; PP analysis: 177/193 [91.7%] vs. 176/191 [92.1%], with a rate difference of -0.4% [-5.6% to 6.4%]). Except for dizziness more common (35/215 [16.3%] vs. 13/214 [6.1%], P = 0.001) in minocycline-containing therapy groups, the incidence of adverse events (75/215 [34.9%] vs. 88/214 [41.1%]) and compliance (195/215 [90.7%] vs. 192/214 [89.7%]) were similar between the two groups.

Conclusion:
The eradication efficacy of minocycline-containing BQT was noninferior to tetracycline-containing BQT as first-line regimen for H. pylori eradication with similar safety and compliance.

Trial registration:
ClinicalTrials.gov, ChiCTR 1900023646.