bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment‐Responsive BAPTA‐AM/BAC Co‐Delivery Nanosystem
Authors: Yan Jiahui , Wang Yanan , Zhang Jingwen , Liu Xiaohu , Yu Liangmin , He Zhiyu 
Published: January 2023

AbstractCalcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI), are self‐amplifying and mutually reinforcing, forming a complicated cascading feedback loop that induces kidney cell “suicide” and ultimately renal failure. There are currently no clinically effective drugs for the treatment of AKI, excluding adjuvant therapy. In this study, a porous silicon‐based nanocarrier rich in disulfide bond skeleton (<50 nm) is developed that enables efficient co‐loading of the hydrophilic drug borane amino complex and the hydrophobic drug BAPTA‐AM, with its outer layer sealed by the renal tubule‐targeting peptide PEG‐LTH. Once targeted to the kidney injured site, the nanocarrier structure collapses in the high glutathione environment of the early stage of AKI, releasing the drugs. Under the action of the slightly acidic inflammatory environment and intracellular esterase, the released drugs produce hydrogen and BAPTA, which can rapidly eliminate the excess ROS and overloaded Ca2+, blocking endoplasmic reticulum/mitochondrial apoptosis pathway (ATF4‐CHOP‐Bax axis, Casp‐12‐Casp‐3 axis, Cyt‐C‐Casp‐3 axis) and inflammatory pathway (TNF‐α‐NF‐κB axis) from the source, thus rescuing the renal cells in the “critical survival” state and further restoring the kidney function. Overall, this nanoparticle shows substantial clinical promise as a potential therapeutic strategy for I/R injury‐related diseases.
Honoring Diverse Cultures Through Family Literacy Approaches That Build Family, School, and Community Partnerships
Authors: Miller Gloria E. , Khatib Sara M. 
Published: January 2023

AbstractFamilies play a critical role in promoting students’ literacy development. Family literacy practices refer to oral, written, and reading strategies that impart cultural traditions and knowledge of the world and that occur in the dominant or native language of a family. It is especially important for educators to understand and build upon such practices when working with multilingual, immigrant, refugee, or asylee students who are the first in their family to attend school in a new host country. Unfortunately, teachers frequently report they are at a loss as to how to engage with the adult guardians of these students on joint efforts to encourage reading in a second language. In this review, effective family literacy programs published in the last several decades reported in the U.S. or internationally are analyzed for how they promote early English literacy skills while honoring a family's native language and culture and simultaneously encouraging strong partnerships between homes, schools, and communities. Culturally sustaining pedagogical approaches reflected within these programs provide ideas for how to intentionally encourage future enhancements of family literacy programming and research.
Introduction
Authors: Al-Tamimi Nawaf , Amin Azzam , Zarrinabadi Nourollah 
Published: January 2023

AbstractThis chapter presents the introductory remarks about the book and its content. In so doing, the chapter describes the blockade of Qatar and the ways in which Qatari government reacted to it. The authors describe different analytical perspectives and arguments put forward to understand Qatari policies in order to respond to the blockade. The chapter ends with an overview of the content of different chapters and the organization of the study.
Erfahrungen und Lösungsansätze für die Einführung eines digitalen Assistenzsystems in der Instandhaltung
Authors: Keller Alinde , Schöner Judith , de la Barré Jeanette , Groß Hardy , Ehlers Thalke , Schulze Martin , Kühnel Hagen , Motsch Christian , Haase Tina , Weber Susanne Maria 
Published: January 2023

ZusammenfassungDigitale Assistenzsysteme fördern den Austausch und den Erhalt von Wissen in Unternehmen. Ein Einsatzfeld ist die Instandhaltung, wo Problemlösefähigkeiten und Erfahrungswissen gefordert sind. Um das Potenzial von Assistenzsystemen zu realisieren, müssen diese erfolgreich in den Arbeitsalltag integriert sein. Im Projekt EVerAssist wurde daher der Einführungsprozess eines kognitiven Assistenzsystems für die Instandhaltung in KMU gestaltet und erforscht. Die Ergebnisse zeigen: Eine erfolgreiche Einführung hat mehrere Stellschrauben. Diese sind z. B. ein Vorgehen für die Erfassung von relevantem Erfahrungswissen, das von den Instandhaltern mitgetragen wird. Auch das Anlegen einer Ablagestruktur für Assistenzinhalte oder ein ganzheitliches Befähigungskonzept zur Gestaltung des digitalen Wissenstransfers zählen dazu.Der Beitrag stellt für diese und weitere Gestaltungsfelder Erfahrungen und Lösungsansätze aus dem Projekt vor. Den wissenschaftlichen Rahmen bildet ein organisationspädagogischer Designforschungs-Ansatz. Abschließend werden zentrale Erfolgsfaktoren sowie die Übertragbarkeit der entwickelten Lösungen herausgearbeitet.
Particle Identification
Authors: Hanagaki Kazunori , Tanaka Junichi , Tomoto Makoto , Yamazaki Yuji 
Published: January 2023

AbstractIn this chapter, we discuss the method of particle identification, which is also called object identification because what we reconstruct or identify is usually not a particle but an object such as a charged particle trajectory, a jet that is a cluster of many particles, missing transverse energy and so on.
Higher-group structure in 2n-dimensional axion-electrodynamics
Authors: Nakajima Tatsuki , Sakai Tadakatsu , Yokokura Ryo 
Published: January 2023

Abstract
We investigate 2n-dimensional axion electrodynamics for the purpose of exploring a higher-group structure underlying it. This is manifested as a Green-Schwarz transformation of the background gauge fields that couple minimally to the conserved currents. The n = 3 case is studied most intensively. We derive the identities of correlation functions among the global symmetry generators by using a gauge transformation that maps two correlation functions with each other. A key ingredient in this computation is given by the Green-Schwarz transformation and the ’t Hooft anomalies associated with the gauge transformation. The algebraic structure of these results and its physical interpretations are discussed in detail. In particular, we find that the higher-group structure for n = 3 is endowed with a multi-ary operation among the symmetry generators.
The sphaleron rate from 4D Euclidean lattices
Authors: Mancha Marc Barroso , Moore Guy D. 
Published: January 2023

Abstract
We develop a new method to determine thermal activation rates, such as for bubble nucleation, topology change, etc., using 4-dimensional Euclidean methods. This allows nonperturbative study on the lattice. We then investigate the strong sphaleron rate in pure-glue QCD at temperatures between 1.3 Tc and 1000 Tc, making contact with previous results but extending them down close to the critical temperature. The extension to full QCD will be straightforward. Limitations of the proposal (the inability to compute a certain dynamical prefactor, puzzling large-volume behavior, and the inability to treat temperatures T < 1.3 Tc) are also discussed.
Long range, large charge, large N
Authors: Giombi Simone , Helfenberger Elizabeth , Khanchandani Himanshu 
Published: January 2023

Abstract
We study operators with large charge j in the d-dimensional O(N) model with long range interactions that decrease with the distance as 1/rd+s, where s is a continuous parameter. We consider the double scaling limit of large N, large j with $$ j/N=\hat{j} $$
j
/
N
=

j
̂

fixed, and identify the semiclassical saddle point that captures the two-point function of the large charge operators in this limit. The solution is given in terms of certain ladder conformal integrals that have recently appeared in the literature on fishnet models. We find that the scaling dimensions for general s interpolate between $$ {\Delta }_j\sim \frac{\left(d-s\right)}{2}j $$

∆
j

∼

d
−
s

2

j
at small $$ \hat{j} $$

j
̂

and $$ {\Delta }_j\sim \frac{\left(d+s\right)}{2}j $$

∆
j

∼

d
+
s

2

j
at large $$ \hat{j} $$

j
̂

, which is a qualitatively different behavior from the one found in the short range version of the O(N) model. We also derive results for the structure constants and 4-point functions with two large charge and one or two finite charge operators. Using a description of the long range models as defects in a higher dimensional local free field theory, we also obtain the scaling dimensions in a complementary way, by mapping the problem to a cylinder in the presence of a chemical potential for the conserved charge.
Diametrically Complete Sets with Empty Interior and Constant Width Sets with Empty Interior
Authors: Kaczor Wiesława , Kuczumow Tadeusz , Reich Simeon , Walczyk Mariola 
Published: January 2023

AbstractWe show that each infinite-dimensional reflexive Banach space $$(X,\left\| \cdot \right\| _X)$$

(
X
,

·

X

)

has an equivalent norm $$\left\| \cdot \right\| _{X,0}$$

·

X
,
0

such that $$(X,\left\| \cdot \right\| _{X,0})$$

(
X
,

·

X
,
0

)

is LUR and contains a diametrically complete set with empty interior. We also prove that after a suitable equivalent renorming, the Banach space $$C([0,1],{\mathbb {R}})$$

C
(
[
0
,
1
]
,
R
)

contains a constant width set with empty interior.
The queens of the stingless bees: from egg to adult
Authors: Bueno F. G. B. , dos Santos C. F. , Otesbelgue A. , Menezes C. , van Veen J. , Blochtein B. , Gloag R. , Heard T. , Imperatriz-Fonseca V. L. , Alves D. A. 
Published: January 2023

AbstractQueens play an essential role in the colonies of stingless bees. Typically, only one queen occurs in a colony at any time, and she dominates the egg laying. Their presence maintains colony cohesion and ensures the development and survivorship of these matriarchal societies. Yet there remain significant gaps in our knowledge of queen life cycles as compared to their daughters, the workers. In this review, we follow chronologically the life of queens from pre-emergence inside brood cells (caste determination), to their interaction with workers (queen selection) and males (sexual selection), and up to adulthood. Stingless bee queens can be determined either trophically or genetically. After emergence, the virgin queens undergo a selection process whereby many are executed by workers. The body size, pheromones, age and behaviour of virgin queens may play a role in queen selection. Queens then leave the nest on a nuptial flight during which they mate just once. After mating, queens are still susceptible to workers’ harassment. For example, if they produce diploid males they are killed by workers. Previous studies have successfully in vitro reared and mated virgin queens under laboratory conditions, which have revealed new insights of queen development time, the threshold of minimum and maximum provided food to larvae developing into queens, and lethal and sublethal effects of agrochemical substances. These new techniques have also provided new information about queen physiology. However, the daily routine of queens inside colonies demands further well-designed experiments to capture other patterns of behaviour which remain poorly understood, including their interactions with other queens, workers and even males.
Asymptotic Simplification of Aggregation-Diffusion Equations Towards the Heat kernel
Authors: Carrillo José A. , Gómez-Castro David , Yao Yao , Zeng Chongchun 
Published: January 2023

AbstractWe give sharp conditions for the large time asymptotic simplification of aggregation-diffusion equations with linear diffusion. As soon as the interaction potential is bounded and its first and second derivatives decay fast enough at infinity, then the linear diffusion overcomes its effect, either attractive or repulsive, for large times independently of the initial data, and solutions behave like the fundamental solution of the heat equation with some rate. The potential $$W(x) \sim \log |x|$$

W
(
x
)
∼
log
|
x
|

for $$|x| \gg 1$$

|
x
|
≫
1

appears as the natural limiting case when the intermediate asymptotics change. In order to obtain such a result, we produce uniform-in-time estimates in a suitable rescaled change of variables for the entropy, the second moment, Sobolev norms and the $$C^\alpha $$

C
α

regularity with a novel approach for this family of equations using modulus of continuity techniques.
Polyangiitis overlap syndrome: a rare clinical entity
Authors: Bruno Lorenza , Mandarano Martina , Bellezza Guido , Sidoni Angelo , Gerli Roberto , Bartoloni Elena , Perricone Carlo 
Published: January 2023

AbstractPolyangiitis overlap syndrome is a rare clinical entity comprising patients with overlapping features of more than one vasculitis, usually eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis (GPA). Few cases of polyangiitis overlap syndrome have been described in the literature, mostly associated with c-ANCA, anti-proteinase (PR)-3 positivity, a protean clinical picture characterized by vasculitis, eosinophilia and eosinophilic infiltrates in tissues and a favorable response to steroids and immunosuppressant treatments. Herein, we present a case of a 66-year-old woman with nasal obstruction, external nose deformity, sensorineural hearing loss, peripheral blood eosinophilia, high titer anti-PR3 antibodies and lung involvement. Nasal septum biopsies showed inflammatory infiltrate with eosinophilic component; histopathology of the lung demonstrated necrotizing granulomas associated with inflammatory infiltrate composed of numerous neutrophils and some eosinophils. The patient was diagnosed with polyangiitis overlap syndrome and successfully treated with cyclophosphamide. Recognizing this entity is fundamental given the distinct clinical phenotype and outcomes to therapy in the complex scenario of ANCA-associated vasculitides.
Reduced anterior insular cortex volume in male heroin addicts: a postmortem study
Authors: Müller Ulf J. , Schmalenbach Lucas J. , Dobrowolny Henrik , Guest Paul C. , Schlaaff Konstantin , Mawrin Christian , Truebner Kurt , Bogerts Bernhard , Gos Tomasz , Bernstein Hans-Gert , Steiner Johann 
Published: January 2023

AbstractWe and others have observed reduced volumes of brain regions, including the nucleus accumbens, globus pallidus, hypothalamus, and habenula in opioid addiction. Notably, the insular cortex has been under increasing study in addiction, and a smaller anterior insula has been found in alcohol-addicted cases. Here, we have investigated whether similar effects occur in heroin addicts compared to healthy controls. Volumes of the anterior and posterior insula in heroin addicts (n = 14) and controls (n = 13) were assessed by morphometry of Nissl-myelin-stained serial whole-brain coronal sections. The mean relative volume of the anterior insular cortex was smaller than in non-addicted controls (3010 ± 614 *10–6versus 3970 ± 1306 *10–6;p = 0.021). However, no significant differences in neuronal cell counts were observed. Therefore, the observed volume reduction appears to be a consequence of damaged connecting structures such as neuropil and glial cells. The findings were not confounded by age or duration of autolysis. Our results provide further evidence of structural deficits in key hubs of the addiction circuitry in heroin-dependent individuals and warrant further research in this area.
Dysphagia After Esophageal Replacement and Its Treatment
Authors: Horváth Örs Péter , Pavlovics Gábor , Cseke László , Vereczkei András , Papp András 
Published: January 2023

AbstractDysphagia occurs temporarily or permanently following esophageal replacement in at least half of the cases. Swallowing disorder, in addition to severe decline in the quality of life, can lead to a deterioration of the general condition, which may lead to death if left untreated. For this reason, their early detection and treatment are a matter of importance. Between 1993 and 2012, 540 esophageal resections were performed due to malignant tumors at the Department of Surgery, Medical Center of the University of Pécs. Stomach was used for replacement in 445 cases, colon in 38 cases, and jejunum in 57 cases. The anastomosis with a stomach replacement was located to the neck in 275 cases and to the thorax in 170 cases. The colon was pulled up to the neck in each case. There were 29 cases of free jejunal replacements located to the neck and 28 cases with a Roux loop reconstruction located to the thorax. Based on the literature data and own experience, the following were found to be the causes of dysphagia in the order of frequency: anastomotic stenosis, conduit obstruction, peptic and ischemic stricture, foreign body, local recurrence, functional causes, new malignant tumor in the esophageal remnant, and malignant tumor in the organ used for replacement. Causes may overlap each other, and their treatment may be conservative or surgical. The causes of many dysphagic complications might be prevented by improving the anastomosis technique, by better preservation the blood supply of the substitute organ, by consistently applying a functional approach, and by regular follow-up.
Monolithic parallel overlapping Schwarz methods in fully-coupled nonlinear chemo-mechanics problems
Authors: Kiefer Bjoern , Prüger Stefan , Rheinbach Oliver , Röver Friederike 
Published: January 2023

AbstractWe consider the swelling of hydrogels as an example of a chemo-mechanical problem with strong coupling between the mechanical balance relations and the mass diffusion. The problem is cast into a minimization formulation using a time-explicit approach for the dependency of the dissipation potential on the deformation and the swelling volume fraction to obtain symmetric matrices, which are typically better suited for iterative solvers. The MPI-parallel implementation uses the software libraries deal.II, p4est and FROSch (Fast of Robust Overlapping Schwarz). FROSch is part of the Trilinos library and is used in fully algebraic mode, i.e., the preconditioner is constructed from the monolithic system matrix without making explicit use of the problem structure. Strong and weak parallel scalability is studied using up to 512 cores, considering the standard GDSW (Generalized Dryja-Smith-Widlund) coarse space and the newer coarse space with reduced dimension. The FROSch solver is applicable to the coupled problems within in the range of processor cores considered here, although numerical scalablity cannot be expected (and is not observed) for the fully algebraic mode. In our strong scalability study, the average number of Krylov iterations per Newton iteration is higher by a factor of up to six compared to a linear elasticity problem. However, making mild use of the problem structure in the preconditioner, this number can be reduced to a factor of two and, importantly, also numerical scalability can then be achieved experimentally. Nevertheless, the fully algebraic mode is still preferable since a faster time to solution is achieved.
Local gingival crevicular fluid, synovial fluid, and circulating levels of prolactin hormone in patients with moderately active rheumatoid arthritis and stage III and IV periodontitis before and after non-surgical periodontal treatment—a controlled trial
Authors: El-Wakeel Naglaa Mohamed , Shalaby Zienab Farid , Abdulmaguid Rania Farouk , Elhamed Sally Said Abd , Shaker Olfat 
Published: January 2023

Abstract
Objectives
We aimed to investigate prolactin (PRL) levels in gingival crevicular fluid (GCF), synovial fluid, and serum in patients suffering from moderately active rheumatoid arthritis (RA) with and without periodontitis (P). Further, to evaluate the effect of non-surgical periodontal treatment on these levels compared to controls.

Materials and methods
Eighty subjects were divided into 4 groups: group 1: 20 patients with RA + P, group 2: 20 periodontitis patients (systemically healthy), group 3: RA patients (periodontally healthy), and group 4: healthy controls. Patients with periodontitis received scaling and root planning (SRP). PRL was measured using enzyme‐linked immunosorbent assay.

Results
At baseline, in GCF of RA + P group showed the highest mean PRL levels, followed by P group whereas groups 3 and 4 showed a statistically less values than the first 2 groups. Serum values showed non-significant difference between the first three groups, although higher than healthy controls. SRP reduced GCF and serum levels of PRL in both P groups as well as synovial fluid PRL in group 1. SRP caused no change in DAS scores while reduced ESR values were observed in group 1 after treatment.

Conclusions
Local GCF and synovial levels of PRL seem to be linked to the disease process of both periodontitis and rheumatoid arthritis than serum levels. SRP reduced these local levels.

Clinical relevance
In patients with RA and CP, local PRL seems to play a role in the association between the two conditions; further, periodontal treatment is essential to improve periodontal condition in RA patients.

Trial registration
Clinicaltrials.gov. Identifier: NCT04279691.
Interpretable tabular data generation
Authors: Zhang Yishuo , Zaidi Nayyar , Zhou Jiahui , Li Gang 
Published: January 2023

AbstractGenerative adversarial network () models have been successfully utilized in a wide range of machine learning applications, and tabular data generation domain is not an exception. Notably, some state-of-the-art models of tabular data generation, such as , , , etc. are based on models. Even though these models have resulted in superior performance in generating artificial data when trained on a range of datasets, there is a lot of room (and desire) for improvement. Not to mention that existing methods do have some weaknesses other than performance. For example, the current methods focus only on the performance of the model, and limited emphasis is given on the interpretation of the model. Secondly, the current models operate on raw features only, and hence they fail to exploit any prior knowledge on explicit feature interactions that can be utilized during data generation process. To alleviate the two above-mentioned limitations, in this work, we propose a novel tabular data generation model—GenerativeAdversarial Network modelling inspired fromNaiveBayes andLogisticRegression’s relationship ($${ { \texttt {GANBLR} } }$$
GANBLR
), which not only address the interpretation limitation of existing tabular -based models but provides capability to handle explicit feature interactions as well. Through extensive evaluations on wide range of datasets, we demonstrate $${ { \texttt {GANBLR} } }$$
GANBLR
’s superior performance as well as better interpretable capability (explanation of feature importance in the synthetic generation process) as compared to existing state-of-the-art tabular data generation models.