bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholesterol induces inflammation and reduces glucose utilization
Authors: Hong Pingping , Wang Qing , Chen Guoping 
Published: May 2023

Abstract
Cholesterol stimulates inflammation and affects the normal function of islet tissues. However, the precise mechanism underlying the effects of cholesterol on islet cells requires clarification. In this study, we explored the role of cholesterol in glucose utilization in pancreatic cells. Beta-TC-6 cells and mice were treated with cholesterol. We used glucose detection kits to identify the glucose content in the cell culture supernatant and mouse serum and an enzyme-linked immunosorbent assay was used to detect insulin levels in the serum. Glucose-6-phosphatase catalytic subunit 2 (G6PC2), 78 kDa glucose-regulated protein (GRP78), 94 kDa glucose-regulated protein (GRP94), nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), caspase-1 (casp1), and interleukin-1β (IL-1β) expression levels were detected using immunofluorescence, immunohistochemistry, western blotting, and reverse transcription-quantitative polymerase chain reaction. Hematoxylin–eosin staining was used to detect the histological alterations in pancreatic tissues. Cholesterol decreased beta-TC-6 cell glucose utilization; enhanced pancreatic tissue pathological alterations; increased glucose and insulin levels in mouse serum; increased G6PC2, GRP78, GRP94, and NLRP3 expression levels; and elevated casp1 and pro-IL-1β cleavage. Cholesterol can attenuate glucose utilization efficiency in beta-TC-6 cells and mice, which may be related to endoplasmic reticulum stress and inflammation.
Thermal characterization of heat source (sink) on hybridized (Cu–Ag/EG) nanofluid flow via solid stretchable sheet
Authors: Hussain Syed M. , Eid Mohamed R. , Prakash M. , Jamshed Wasim , Khan Abbas , Alqahtani Haifa 
Published: May 2023

Abstract
The goal of this research is to consider the thermal impact on varied convection flow in hybrid nanofluids with heat generation over a two-dimensional heated flat around a stretchable sheet. The flow is considered steady and incompressible while the stretchable sheet is assumed an impermeable. Two distinctive nano-level particles are considered, namely copper (Cu) and silver (Ag) with ethylene glycol base fluid. The boundary layer was generated on a stretchable sheet surface by mixed convection flow in hybrid nanofluids. Ideally, the sink and source are thermal reservoirs of internal thermal capacities. This means you can extract or reject heat from them without changing their temperature. To make a study of thermodynamic systems like heat engines and refrigerator systems, the governing equations were solved numerically with Keller-box methodology depending on the implicit finite-difference technique. Research findings were worked with the parameters of mixed convection, Prandtl number, nanoparticle volume fraction, through various non-dimensional parameters, and heat generation. Especially for thermal generation enhancement, the fluidity and thermal dispersal get elevated. Even though the flowing behavior and the thermal dispersal of hybridity fluids with the combinations of Cu and Ag nanoparticles were similar, their values are distinct, which reflect in graphical displays. The hybrid nanofluidity gets improved with the volume variation of nanoparticles if the

ϕ

\phi

value is

0.01
≤
ϕ
≤
0.05

0.01\le \phi \le 0.05

and if the flow profile value decreases

ϕ

h

{\phi }_{{\rm{h}}}

, where

0.01
≤

ϕ

h

≤
0.05

0.01\le {\phi }_{{\rm{h}}}\le 0.05

as the dispersal of temperature enhances when the nanoparticle nanofluid constraint is improved.
Deutungsmodelle von Arbeit im Spiegel kolonialer und geschlechtlicher Dimensionen:
Authors: Wobbe Theresa , Renard Léa , Schalkowski Nicola , Braig Marianne 
Published: May 2023

ZusammenfassungAus wissenssoziologischer Perspektive fragt dieser Beitrag nach Deutungsmodellen von Arbeit, die historisch-soziologisch aus Debatten über freie vs. unfreie Arbeit erschlossen werden. Um das Begriffs- und Referenzfeld dieser Unterscheidung zu analysieren, verwenden wir O. Pattersons Soziologie der Sklaverei und der Freiheit als theoretischen Bezugsrahmen. Sie wird durch die historische Wissenssoziologie und die vergleichstheoretische Perspektive spezifiziert. Empirisch basiert der Beitrag auf einer explorativen Studie zur Kategorisierung von Zwangsarbeit durch die International Labour Organization (ILO), die den instruktiven Fall einer frühen internationalen Beobachtungsordnung bildet. Die Ergebnisse zeigen, dass die Kategorisierung in den kulturellen Rahmen der europäischen Zivilisierungsmission eingebettet war. Zwangsarbeit wurde im Spiegel kolonialer und geschlechtlicher Differenzierung von der Sklaverei unterschieden und am Kriterium der freien Lohnarbeit verglichen. Der heuristische Gewinn des Beitrags liegt darin, die Wissenskultur und historische Kontingenz freizulegen, in der heutige soziologische Begriffe von Arbeit, Differenzierung und Geschlecht entstanden sind.
Semantik und soziale Rationalität der universalistischen Moral – eine universelle oder kulturspezifische Konstruktion?
Authors: Rosenow Joachim 
Published: May 2023

ZusammenfassungDer universalistischen Moral, dem moralischen Komplement zu den Menschenrechten, wird in philosophischen und politischen Diskursen der Gegenwart ein universeller Geltungsanspruch zugewiesen. Dieser Anspruch kann sich aber kaum auf kognitiv überzeugende Begründungen stützen. In Auseinandersetzung mit dieser Situation führe ich drei Thesen aus: 1) Produktiver als die wiederholte Behauptung eines universellen Geltungsanspruches erscheint eine Lesart, die diese Moral auf dem Hintergrund einer Unterscheidung von universell und kulturspezifisch als eine kulturspezifische Moral interpretiert. 2) In ihrer auf die Freiheit des Individuums zentrierten Semantik ist diese Moral eng mit den Ordnungsproblemen moderner, funktional differenzierter Gesellschaften und den Beweglichkeitsanforderungen an die Subjekte verwoben. 3) In ihrem unausgeglichenen Verhältnis von Rechten und Pflichten weist diese Moral eine Selbstwidersprüchlichkeit und begrenzte Rationalität auf. Sie ist – so meine These – tief in destruktive Funktionszusammenhänge kapitalistischer Ökonomie eingebunden, ohne einen antizipativen Blick dafür zu öffnen.
Viral Coinfections in Kawasaki Disease: A Meta-analysis
Authors: Neubauer Hannah C. , Lopez Michelle A. , Haq Heather A. , Ouellette Lara , Ramirez Andrea A. , Wallace Sowdhamini S. 
Published: May 2023

CONTEXT
Viral infections are suspected triggers in Kawasaki disease (KD); however, a specific viral trigger has not been identified.

OBJECTIVES
In children with KD, to identify (1) overall prevalence of viral infections; (2) prevalence of specific viruses; and (3) whether viral positivity was associated with coronary artery aneurysms (CAAs) or refractoriness to intravenous immunoglobin (IVIG).

DATA SOURCES
We searched Embase, Medline, and Cochrane databases and gray literature.

STUDY SELECTION
Eligible studies were conducted between 1999 and 2019, and included children diagnosed with KD who underwent viral testing.

DATA EXTRACTION
Two investigators independently reviewed full-text articles to confirm eligibility, extract data, appraise for bias, and assess evidence quality for outcomes using the Grading of Recommendations Assessment Development and Evaluation criteria. We defined viral positivity as number of children with a positive viral test divided by total tested. Secondary outcomes were CAA (z score ≥2.5) and IVIG refractoriness (fever ≥36 hours after IVIG).

RESULTS
Of 3189 unique articles identified, 54 full-text articles were reviewed, and 18 observational studies were included. Viral positivity weighted mean prevalence was 30% (95% confidence interval [CI], 14–51) and varied from 5% to 66%, with significant between-study heterogeneity. Individual virus positivity was highest for rhinovirus (19%), adenovirus (10%), and coronavirus (7%). Odds of CAA (odds ratio, 1.08; 95% CI, 0.75–1.56) or IVIG refractoriness (odds ratio, 0.88; 95% CI, 0.58–1.35) did not differ on the basis of viral status.

LIMITATIONS
Low or very low evidence quality.

CONCLUSIONS
Viral infection was common with KD but without a predominant virus. Viral positivity was not associated with CAAs or IVIG refractoriness.
Calidad de vida en pacientes egresados de una unidad de cuidados intensivos de tercer nivel; estudio prospectivo de 12 meses
Authors: Campos Vargas Carolina , Salas Segura Donato 
Published: May 2023

La calidad de vida los pacientes que son egresados de las unidades de cuidado intensivo es una preocupación frecuente por la alta incidencia de secuelas cognitivas y las complicaciones funcionales que padece esta población luego de su egreso. Este trabajo presenta el resultado de un seguimiento de 6 meses de pacientes que pasaron por cuidados intensivos y luego del alta hospitalaria. Este estudio fue parte de una investigación mayor que dio seguimiento a los pacientes por espacio total de 12 meses. Materiales y método: Se trató de un estudio observacional, descriptivo y prospectivo de un año de duración que dio seguimiento a los pacientes egresados de la UCI hasta los 6 meses del egreso hospitalario. La información recabada incluyó datos demográficos y de condición de salud que se recolectaron al ingreso a la UCI, al momento del alta hospitalaria, a los 28 días y a los 6 meses. Además, se evaluó la calidad de vida a partir de su grado de independencia y reinserción laboral o regreso a las actividades normales. Resultados: Completaron el estudio un total de 118 pacientes, 52% de ellos hombres, con una edad promedio de 50 años. La estancia promedio en la Unidad fue de 6,5 días y la estancia promedio de hospitalización posterior a la UCI fue de 6 días. La mayor parte de los pacientes ingresaron por cardiopatía isquémica. La mortalidad intrahospitalaria fuera de la unidad de cuidados intensivos fue del 3%, con una mortalidad a los 28 días de un 3%, para una mortalidad global del 14 % a los 6 meses. A los 6 meses, el 64% de los pacientes tenían una reinserción adecuada, 24% tenían problemas en un área, 10% presentaban problemas en dos áreas, y el 1% presentó problemas en 3 áreas. Las mujeres presentaron una mejor tasa de reinserción. Conclusión: A los 6 meses, los pacientes egresados de la unidad de cuidados intensivos presentan un alto porcentaje de reinserción completa a sus labores habituales. Los hombres presentaron mayores problemas de reinserción en relación a secuelas de trauma.
Autologous platelet-rich plasma treatment in a dog with vincristine extravasation injury
Authors: Boztok Ozgermen Basak 
Published: May 2023

AbstractExtravasation of vincristine sulfate (VS) is a common complication encountered during canine transmissible venereal tumor treatment and other hematopoietic neoplasms, such as lymphoma and leukemias. The leakage of the chemotherapeutic agent may result in soft tissue damage leading to ulceration and necrosis. Studies have shown that platelet-rich plasma consists of growth factors and cytokines, thus plays a crucial role in wound healing. This study aimed to evaluate the effects of autologous platelet-rich plasma and antimicrobial wound dressing for the treatment of VS extravasation-related acute full-thickness skin wounds. A male Aksaray Malakli shepherd dog (3 years old) was brought to our clinic with a wound on the left forelimb which appeared two days after intravenous injection of VS. Extravasation was suspected. A total of 3.5 mL autologous platelet-rich plasma was injected into the wound margins and an antimicrobial dressing containing chlorhexidine acetate was used weekly to close the wound. The wound healed without any complications in 6 weeks. It was concluded that autologous platelet-rich plasma treatment is a simple and cost-effective method for the treatment of VS extravasation-related acute full-thickness skin wounds.
African Latin: The problem of labdacism
Authors: Bohacsek Dóra 
Published: May 2023

AbstractIn late antiquity, there has been a public opinion that African Latin is specific and different from the Latin spoken in other regions of the Roman Empire. Several grammarians also mention – in comparison with the so-called classical Latin – incorrect (linguistic) phenomena, which are associated with the Latin speakers of the African provinces. In my paper, I will examine one of these (perceived?) Africanisms, the wrong use of the l sound/letter (labdacism) through a selection of texts available in the grammatical tradition, and finally, with the inclusion of African epigraphical material, I will discuss the phenomenon of wrong gemination and degemination in African provinces, which might closely be related to the phenomenon called labdacism by grammarians.
The influence of calcium formate on the hydration of calcium sulfate hemihydrate
Authors: Fobbe Nicholas , Goetz-Neunhoeffer Friedlinde , Jansen Daniel 
Published: May 2023

AbstractIn this study, the influence of calcium formate (CF) on the hydration of a synthesized calcium sulfate hemihydrate (HH) powder was investigated. Isothermal calorimetry measurements showed that CF retards the hydration reaction of HH. This was confirmed by XRD of stored samples and pore solution analysis. Two retardation mechanisms were identified. The combination of pore solution and laser granulometric experiments revealed that firstly, the initial dissolution of hemihydrate decelerates because of high Ca2+ ion concentrations, donated by the faster dissolving CF. Secondly, the HCOO− species of CF adsorb on surfaces of the gypsum crystals, as further pore solution measurements showed. This impedes their formation kinetic. The gypsum crystals exhibited anisotropic peak narrowing in XRD measurements when CF was added. This was caused by a morphology change, which could be verified using the anisotropic domain size morphology approach during Rietveld refinement analysis and SEM images. Gypsum crystals exhibit a blockier shape with CF addition compared to the usual acicular shape in pure water.
Pengembangan Monopoli Bahasa Arab untuk Pembelajaran Kosakata Kelas IX Madrasah Tsanawiyah
Authors: Larasati Ariyani Dwi , Ahsanuddin Mohammad 
Published: May 2023

Monopoli bahasa Arab untuk pembelajaran kosakata merupakan hasil modifikasi dari monopoli bergambar berbagai negara menjadi kartu kosakata bahasa Arab. Tujuan dalam penelitian ini men-deskripsikan pengembangan dan kelayakan monopoli bahasa Arab untuk pembelajaran kosakata kelas IX MTs. Dengan metode penelitian dan pengembangan yang bertujuan menghasilkan dan menguji kelayakan produk. Menggunakan model ADDIE yang meliputi tahap analisis dengan me-wawancarai guru bahasa Arab dan perwakilan siswa kelas IX MTs Darussalam untuk memperoleh informasi permasalahan tentang kosakata. Tahap desain, peneliti membuat prototipe monopoli ba-hasa Arab untuk pembelajaran kosakata. Tahap pengembangan, peneliti mengembangkan prototipe hingga menjadi produk cetak dan memvalidasinya kepada guru bahasa Arab MTs Darussalam, ahli materi dan ahli media. Tahap implementasi, peneliti melakukan uji coba kepada 20 siswa kelas IX MTs. Adapun hasil pengembangan monopoli bahasa Arab untuk pembelajaran kosakata yaitu papan monopoli, daftar pertanyaan, petunjuk permainan, kunci jawaban dan hasil kelayakan monopoli 94 persen aspek materi dan 94 persen aspek media dari guru bahasa Arab MTs Darussalam, 88 persen dari ahli materi, 90,6 persen dari ahli media dan setelah melakukan uji coba 96,6 persen dari 20 respon siswa kelas IX MTs Darussalam, serta peningkatan nilai rata-rata siswa dari 50 menjadi 80. Sehingga Monopoli bahasa Arab untuk pembelajaran kosakata kelas IX Madrasah Tsanawiyah sangat layak sebagai media pembelajaran.
Kata kunci: monopoli; pembelajaran kosakata; bahasa Arab; Madrasah Tsanawiyah; ADDIE
The Development of Arabic Monopoly for Vocabulary Learning for Class IX Islamic Junior High School
The monopoly of Arabic for vocabulary learning modifies various countries’ images to be vocabulary cards. The research aims to describe the development and eligibility of the Arabic monopoly for vocabulary learning class IX MTs. Research methods are research and development to produce and test the eligibility of products, using the ADDIE model with analyze part is the researcher interviewed an Arabic teacher and a student of class IX MTs for information of the problem. Design, the researcher made a prototype. Development, the researcher developed prototype to be product and validated it to Arabic teacher, material expert, and media expert. Implementation, the researchers conducted trials on 20 students IX MTs. And the results of development of the Arabic monopoly for vocabulary learning is a monopoly boards, question lists, game clues, answer keys and the eligibility results were 94 percent of MTs Darussalam Arabic teachers, 88 percent of material experts, 90,6 percent of media experts and 96,6 percent of 20 responses of class IX MTs Darussalam students. There was an increase in the average score of students from 50 to 80. So the monopoly of Arabic for vocabulary learning class IX MTs deserves to be as a learning medium.
Keywords: monopoly; vocabulary learning; Arabic language; junior high school; ADDIE
Un acercamiento a los bancos de biodiversidad: una alternativa para la inversión en conservación y protección de los recursos naturales
Authors: Villanueva Cáceres Gabriela Alejandra 
Published: May 2023

Los recursos naturales pueden protegerse por medio de la implementación de diferentes mecanismos. Uno de estos y sobre el cual versa el presente artículo, son los bancos de biodiversidad. Estos últimos constituyen una medida privada de inversión que tiene como finalidad ayudar en la conservación de especies, hábitats y ecosistemas naturales. Cabe mencionar que los bancos de biodiversidad se han comenzado a implementar con bastante éxito en diferentes países extranjeros. En el presente texto, se analizará qué son los bancos de biodiversidad y cómo estos funcionan. Luego, se abordará la forma en cómo estos bancos han sido regulados e incorporados en ciertos países del extranjero. Finalmente, el artículo destaca los principales beneficios que podría generar la implementación de estos bancos en el caso peruano.
Successful surgical treatment of mediastinal lung hernia with a mesh implant. Consequent results
Authors: Tarasov R. V. , Krasnikova E. V. , Sadovnikova S. S. , Shergina E. A. , Chesalina Y. O. , Bagirov M. A. 
Published: May 2023

An observation from practice is given – surgical treatment of mediastinal pulmonary hernia in a patient after pneumonectomy using the method of anterior mediastinal plastic surgery with a mesh implant with demonstration of long-term results.The patient I. 31 years old was ill with pulmonary tuberculosis for 3 years, treatment was carried out, against which the stenosis of the left main bronchus progressed. The patient underwent endoscopic operations: argonoplasmic destruction of the left main bronchus, balloon dilation of the left main bronchus, with a temporary effect. Due to recurrent stenosis of the left main bronchus, a pneumonectomy was performed on the left. After 7 months, she complained of severe shortness of breath at rest. Computed tomography revealed a displacement of the mediastinal organs to the left, an upper-anterior pulmonary mediastinal hernia of the right lung to the left midclavicular line at the level of the anterior I-IV intercostals on the left. The patient underwent plastic surgery of the anterior mediastinum on the right using a polymer mesh implant. As a result of treatment, after 3 years, radiologically stable restoration of the position of the only right lung in its hemithorax. The patient is functionally compensated, shortness of breath is not observed. The patient has completely returned to her usual lifestyle.
Аortic arch atheroma as a source of arterio-arterial embolism and ischemic stroke
Authors: Ramazanov G. R. , Trofimova A. N. , Kovaleva E. A. , Shevchenko E. V. 
Published: May 2023

Introduction. Currently, despite the introduction of modern diagnostic algorithms in 20-40 % of patients with ischemic stroke, it is not possible to establish its cause. Potential causes of acute cerebral ischemia in patients with cryptogenic ischemic stroke include paroxysmal atrial fibrillation, patent foramen ovale, atrial cardiomyopathy, carotid network, aortic arch atheroma, and cancer-associated thrombophilia.Target: to systematize data on methods for diagnosing and preventing aortic arch atheroma.Material and methods. The literature search was carried out in electronic search systems Scopus, eLibrary, PubMed using the key words: ischemic stroke, cryptogenic stroke, aortic arch atheroma, pathogenesis of ischemic stroke.Results. At present, despite such a detailed study of therapeutic strategies for the prevention of recurrent thrombotic events in patients with aortic arch atheroma, none of the drugs has proven its advantage. Although the NAVIGATE ESUS and RESPECT ESUS trials did not show the superiority of oral anticoagulants over antiplatelet agents in preventing recurrent ischemic strokes in patients with cryptogenic stroke, it was found that cryptogenic ischemic stroke is heterogeneous, which requires a differentiated approach to secondary prevention.Conclusion. Аortic atheroma can be the cause of embolic syndrome and cryptogenic stroke. The main methods for diagnosing aortic atheroma are transesophageal echocardiography and computed tomographic angiography. The therapeutic strategy for the treatment of aortic atheroma is lipid-lowering, antithrombotic therapy in combination with blockers of the renin-angiotensin-aldosterone system.
Whole-body low-dose computed tomography in primary patients with multiple myeloma
Authors: Danilina A. M. , Mendeleeva L. P. , Kostina I. E. , Gribanova E. O. , Ryzhko V. V. , Bal'zhanova Ya. B. 
Published: May 2023

Imaging of bone lesions has an important role in diagnosis of multiple myeloma (MM) and evaluating the response to treatment. Computed tomography scan (CT) allows to detect osteolysis, plasmacytoma and the risk of fractures with high sensitivity. In the National Research Center For Hematologysince 2014 all patients with MM are diagnosed with the whole-body low-dose CT.The aim of the study was to demonstrate the sensitivity of the whole-body low-dose CT and to characterize localization, number and size of bone lesions in primary MM patients.Materials and methods. 50 patients with newly diagnosed MM were enrolled in the study. The diagnosis was established in accordance with international diagnostic criteria. All patients received the whole-body low-dose CT. According to the Durie-Salmon and ISS staging systems 62% and 66% of patients had stage III, respectively.Results. 96% of MM patients had bone lesions. In 30% of patients, bone involvement was the only criterion for CRAB. Pelvic bone lesions was most often diagnosed (92%). The destruction of the long bones of the arms and legs were most rarely detected (42% of patients) and mostly small. The presence of intraosseous plasmocytoma was noted in 40% of cases.Conclusion. The whole-body low dose CT was found to be the most sensitive modality for detection osteolytic bone lesions. Low-dose CT is available in MM case with bone disease only, for establish symptomatic stage. This patients require immedate antimyeloma treatment.