bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemanfaatan Podcast Spotify sebagai Media Pembelajaran Bahasa Indonesia
Authors: Ramadhani Jihan Safira , Firmansyah M. Bayu , Wilujeng Ifin Tri , Putri Nafisah Nilamsari , Nafisah Durotun 
Published: July 2023

Media pembelajaran adalah alat yang digunakan oleh pendidik untuk menyampaikan materi. Seiring berkembangnya teknologi, media pembelajaran hadir dalam berbagai bentuk, salah satunya adalah podcast. Tujuan dari penelitian ini adalah memaparkan proses penggunaan podcast Spotify sebagai media pembelajaran bahasa Indonesia. Metode yang digunakan pada penelitian ini adalah deskriptif-kualitatif dengan desain penelitian studi pustaka. Data penelitian ini diambil dari beberapa buku, jurnal, dan prosiding yang membahas topik serupa. Hasil penelitian ini adalah langkah-langkah pemanfaatan podcast Spotify sebagai media pembelajaran bahasa Indonesia. Adapun langkah-langkah yang dapat dilakukan oleh pendidik yaitu: (1) Mengawali pembelajaran dengan mengadakan pretes untuk menguji kemampuan analisis peserta didik; (2) Mendengarkan materi melalui podcast Spotify yang telah dipersiapkan; (3) Postes dapat diberikan usai peserta didik mendengarkan podcast. Postes ini berguna menguji pengetahuan yang dimiliki oleh peserta didik setelah mendengarkan materi di dalam Spotify. Penggunaan podcast sebagai media pembelajaran dapat melatih kemampuan menyimak peserta didik.
Розробка методик оцінки технологічної якості лікарського засобу у формі мазі
Authors: Ostashchenko Т. М. 
Published: July 2023

Вступ. Розробка нового лікарського засобу потребує встановлення основних показників контролю якості активних фармацевтичних інгредієнтів (АФІ) у складі лікарського засобу. Згідно «Настанови СТ-Н МОЗУ 42-3.2:2004 Лікарські засоби. Специфікації: контрольні випробування та критерії прийнятності» якість лікарського засобу визначається у тому числі і специфікацією. Тобто таких методик випробувань, які відіграють провідну роль у забезпеченні якості АФІ та нового лікарського препарату при їх випуску та протягом терміну зберігання. Тому питання контролю якості лікарських засобів у процесі виробництва та реалізації, розробка методик і методів якісного і кількісного визначення АФІ є актуальною.
Мета дослідження – розробка методик визначення та виявлення активних фармацевтичних інгредієнтів у складі лікарського засобу у формі мазі.
Матеріали і методи. Виявлення лідокаїну гідрохлориду, ібупрофену та метилурацилу проводили методом високоефективної рідинної хроматографії (ВЕРХ) згідно методик, що наведено для кількісного визначення АФІ на рідинному хроматографі «Agilent 1100».
Результати. Хроматографічні дослідження показали достатню селективність та ефективність розділення. Час утримання піків метилурацилу, та ібупрофену складав в середньому 6,44; та 15,3 хв, відповідно. Різниця в часах утримання вказаних компонентів на хроматограмах випробувального розчину та розчину порівняння, не перевищує допустимі 2 %. Коефіцієнт розділення між піками стрептоциду та метилурацилу був не менш 1,0, а між піками метилурацилу та еритроміцину не менш 5,0. Коефіцієнти симетрії піків усіх компонентів не перевищували 1,5. Відносне стандартне відхилення, розраховане для площ піків усіх трьох компонентів не перевищувало 2,0 %. Приблизний час утримання піку лідокаїну гідрохлориду 13,5 хв.
Висновки. Розроблено методики визначення та виявлення АФІ у складі лікарського складу у формі мазі – метод ВЕРХ. На хроматограмі випробувального розчину, час утримання піку лідокаїну гідрохлориду, ібупрофену, метилурацилу збігається з часом утримання піку лідокаїну гідрохлориду, ібупрофену, метилурацилу на хроматограмах розчину порівняння з точністю ± 2 %. Визначення АФІ у складі лікарського засобу показав, що вміст лідокаїну гідрохлориду в 1 г препарату складає 19,84 мг/г при нормі 18 – 22 мг/г., ібупрофену - 40 мг/г при нормі 39,2 – 40,9 мг/г, метилурацилу - 40 мг/г при нормі 39,2 – 40,9 мг/г. знаходиться в межах допустимих норм.
SIKAP REMAJA DALAM PERILAKU PENCEGAHAN HIV/AIDS
Authors: Mahayati Lina , Darmawan Taufan Citra , Santiasari Retty Nirmala 
Published: July 2023

HIV merupakan suatu penyakit yang menyerang sistem kekebalan tubuh seseorang yang disebabkan oleh suatu virus dan dapat menyebabkan AIDS. Penyakit ini muncul tidak mengenal usia karena dapat menyerang siapa saja ketika kekebalan tubuh seseorang melemah khususnya pada remaja. Pendidikan kesehatan akan sangat bermanfaat untuk meningkatkan sikap pemahaman tentang seksual secara sehat dan mencegah terjadinya perilaku menyimpang seksual. Penelitian ini bertujuan untuk menganalisis apakah ada pengaruh pendidikan kesehatan terhadap sikap remaja dalam perilaku pencegahan HIV/AIDS. Metode yang digunakan dalam penelitian ini adalah menggunakan metode deskriptif. Jumlah populasi pada penelitian ini adalah sebanyak 36 dengan jumlah sampel yang digunakan sebagai responden penelitian adalah sebanyak 36 responden kelas 11 SMA di Sidoarjo. Pengambilan sampel dilakukan dengan cara Total Sampling. Instrumen penelitian yang digunakan adalah kuisoner. Hasil penelitian menunjukkan bahwa Sikap remaja tentang pencegahan HIV/AIDS sebanyak 25 remaja (70%) memiliki sikap yang tidak baik dalam pencegahan perilaku HIV/AIDS. Hal ini dapat disimpulkan bahwa remaja perlu mendapatkan edukasi tentang upaya pencegahan perilalu HIV/AIDS, Pihak sekolah diharapkan dapat meningkatkan sikap remaja dalam berperilaku baik dalam mencegah HIV/AIDS melalui edukasi dalam mencegah HIV/AIDS dengan cara mengembangkan kebiasaan hidup sehat yang dilakukan secara terpadu & memberikan edukasi tambahan kepada siswa-siswi mengenai penularan & stigma HIV/AIDS.
LENTES HIDROFÍLICAS: ALTERAÇÕES POR FLUORESCEÍNA SÓDICA
Authors: Trentin Sonoda Rodrigo , Da Silva Francisca Kelly , Alves Pereira Rita de Cássia , Lobianco de Moura Karen 
Published: July 2023

A fluoresceína sódica é um composto de enorme importância para a semiologia sistêmica, em especial para a avaliação ocular. Sua aplicação em diferentes concentrações coopera para exames de imagem como agente de contraste pela alta capacidade de abrasão a diferentes tipos de tecido e avaliação de extravasamento vascular por sua reação a comprimentos de onda específicos. Durante a avaliação ocular utiliza-se para a avaliação de anomalias corneanas como ulcerações, abrasões, desepitelizações e edemas. Para a semiologia em contatologia é aplicado a fluoresceína observando o tempo de ruptura do filme lacrimal, e, é aplicável na avaliação durante a adaptação lentes rígidas de contato. Através de revisão bibliográfica e estudo experimental, busca-se determinar a compatibilidade do corante em testes de adaptação de lentes hidrofílicas, buscando determinar se existe risco de absorção do corante em concentração de 1% e 2% por diferentes materiais hidrofílicos.
ĐẶC ĐIỂM LÂM SÀNG, VI SINH VÀ KẾT QUẢ ĐIỀU TRỊ VIÊM PHỔI CÓ SỬ DỤNG VANCOMYCIN Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI NGHỆ AN
Authors: Bùi Anh Sơn , Nguyễn Thị Diệu Thúy , Nguyễn Thị Thúy Hằng 
Published: July 2023

Tại Việt Nam, viêm phổi là một trong các bệnh đứng hàng đầu gây mắc và tử vong ở trẻ em. Với tình trạng kháng kháng sinh như hiện nay, Vancomycin được lựa chọn là kháng sinh chính điều trị nhiễm khuẩn nặng do vi khuẩn Gram dương ở trẻ em, đặc biệt là Streptococcus pneumoniae. Phương pháp: Đây là nghiên cứu mô tả cắt ngang trên 219 trẻ viêm phổi được điều trị bằng phác đồ có Vancomycin tại bệnh viện sản nhi Nghệ an. Kết quả: Tuổi trung bình của trẻ là 21,3 ± 26,6 tháng, nhóm từ 13-60 tháng tuổi chiếm tỉ lệ cao nhất là 41,1%. Triệu chứng lâm sàng thường gặp nhất là ho và thở nhanh (>90%). 32,1% trẻ mắc viêm phổi xác định được căn nguyên gây bệnh, với nguyên nhân thường gặp nhất là Streptococcus pneumoniae, chiếm 22,4%. Sau 7 ngày điều trị, triệu chứng lâm sàng cải thiện rõ rệt, với 5,9% trẻ sốt, 63,9% giảm khò khè, 62,4% hết rales ở phổi. Tỉ lệ tử vong là 0,8%. Có 2,7% trẻ có phản ứng khi sử dụng vancomycin, chủ yếu là triệu chứng đỏ da. Kết luận: Vancomycin là kháng sinh có hiệu quả trong điều trị viêm phổi. Tuy nhiên không nên chỉ định sử dụng kháng sinh này rộng rãi vì gây tăng nguy cơ kháng thuốc.
Morphometric Assessment of Bi-caudate Index Using Computerized Tomographic Scan from Sokoto North-Western Nigeria
Authors: Danjuma Jibrin Usman , Abubakar Bello 
Published: July 2023

Aim: To determine the bi-caudate index (BCI) of Nigerians using computerized tomography from Sokoto North-Western Nigeria.
Study Design: Retrospective cross- sectional.
Place and Duration of Study: Department of Anatomy Usmanu Danfodiyo University Sokoto and Department of Radiology Usmanu Danfodiyo University Teaching Hospital Sokoto, between January, 2020 and January, 2022.
Methodology: CT scans of 186 apparently healthy normal individuals of age group 1 to 70 years were taken and the subjects were categorized into age intervals of 10 years; males and females taken separately. The linear measurements of caudate and brain were taken directly from the screen. The Bi Caudate Index were calculated. The mean values in each group were compared with age and sex, using appropriate statistical tests.
Results: The least BCI in male was 6.0mm and was seen in the age group 1-10 years while in female the least BCI was 5.0mm, seen in the age group 1-10. The largest BCI in male was 21mm, observed in the age group 61-70years, while the largest BCI in female 19.0mm, seen in the age group 61-70 years.
Conclusion: Bi Caudate Index shows positive correlation with age.
Multi‐Ion Engineering Strategies toward High Performance Aqueous Zinc‐Based Batteries
Authors: Yue Jiasheng , Chen Shi , Yang Jingjing , Li Shuqiang , Tan Guoqiang , Zhao Ran , Wu Chuan , Bai Ying 
Published: July 2023

AbstractAs alternatives to batteries with organic electrolytes, aqueous zinc‐based batteries (AZBs) have been intensively studied. However, the sluggish kinetics, side reactions, structural collapse, and dissolution of the cathode severely compromise the commercialization of AZBs. Among various strategies to accelerate their practical applications, multi‐ion engineering shows great feasibility to maintain the original structure of the cathode and provide sufficient energy density for high‐performance AZBs. Though multi‐ion engineering strategies could solve most of the problems encountered by AZBs and show great potential in achieving practical AZBs, the comprehensive summaries of the batteries undergo electrochemical reactions involving more than one charge carrier is still in deficiency. The ambiguous nomenclature and classification are becoming the fountainhead of confusion and chaos. In this circumstance, this review overviews all the battery configurations and the corresponding reaction mechanisms are investigated in the multi‐ion engineering of aqueous zinc‐based batteries. By combing through all the reported works, this is the first to nomenclate the different configurations according to the reaction mechanisms of the additional ions, laying the foundation for future unified discussions. The performance enhancement, fundamental challenges, and future developing direction of multi‐ion strategies are accordingly proposed, aiming to further accelerate the pace to achieve the commercialization of AZBs with high performance.
A Bioinspired Injectable, Adhesive, and Self‐Healing Hydrogel with Dual Hybrid Network for Neural Regeneration after Spinal Cord Injury
Authors: Xiao Longyou , Xie Pengfei , Ma Junwu , Shi Kaixi , Dai Yu , Pang Mao , Luo Jinghua , Tan Zan , Ma Yahao , Wang Xiaoying , Rong Limin , He Liumin 
Published: July 2023

AbstractHydrogel‐based regenerated scaffolds show promise as a platform for neural regeneration following spinal cord injury (SCI). Nevertheless, the persistent problem of poor mechanical strength and limited integration with the host tissue still exists. In this study, a bioinspired hydrogel with highly sophisticated features for neural regeneration after SCI is developed. The hydrogel is composed of dihydroxyphenylalanine (DOPA)‐grafted chitosan and a designer peptide, offering a unique set of qualities such as being injectable, having self‐healing abilities, and adhering to tissues. Compared to conventional hydrogels, this hydrogel ensures a significant promotion of immune response modulation and axon regrowth while featuring synapse formation of various neurotransmitters and myelin regeneration. Subsequently, functional recoveries are enhanced, including motor function, sensory function, and particularly bladder defect repair. These positive findings demonstrate that the hydrogel has great potential as a strategy for repairing SCI. Moreover, the versatility of this strategy goes beyond neural regeneration and holds promise for tissue regeneration in other contexts. Overall, this proposed hydrogel represents an innovative and multifaceted tool for engineering structures in the biomedical field.
Catenane and Rotaxane Synthesis from Cucurbit[6]uril‐Mediated Azide‐Alkyne Cycloaddition
Authors: Tse Yuen Cheong , Au‐Yeung Ho Yu 
Published: July 2023

AbstractThe chemistry of mechanically interlocked molecules (MIMs) such as catenane and rotaxane is full of new opportunities for the presence of a mechanical bond, and the efficient synthesis of these molecules is therefore of fundamental importance in realizing their unique properties and functions. While many different types of preorganizing interactions and covalent bond formation strategies have been exploited in MIMs synthesis, the use of cucurbit[6]uril (CB[6]) in simultaneously templating macrocycle interlocking and catalyzing the covalent formation of the interlocked components is particularly advantageous in accessing high‐order catenanes and rotaxanes. In this review, catenane and rotaxane obtained from CB[6]‐catalyzed azide‐alkyne cycloaddition will be discussed, with special emphasis on the synthetic strategies employed for obtaining complex [n]rotaxanes and [n]catenanes, as well as their properties and functions.
Zn Promotes Chemical Looping Ammonia Synthesis Mediated by LiH−Li2NH Couple
Authors: Wang Runze , Gao Wenbo , Feng Sheng , Guan Yeqin , Wang Qianru , Guo Jianping , Chen Ping 
Published: July 2023

AbstractChemical looping ammonia synthesis (CLAS) is a promising alternative route to ammonia production because of its advantages of avoiding competitive adsorption of N2 and hydrogen source (H2O or H2) and intervening the scaling relations in the catalytic process. Our previous studies showed that NH3 can be synthesized at low temperatures via a CLAS mediated by an alkali or alkaline earth metal hydride‐imide couple with the aid of transition metal catalysts. Herein, we demonstrate that a group‐IIB metal Zn, which has rarely been studied in the thermal‐catalytic process, can significantly promote the performance of the lithium hydride‐lithium imide (LiH−Li2NH)‐mediated CLAS process (denoted as Zn−LiH−Li2NH). The addition of Zn dramatically changes the reaction pathway of the LiH−Li2NH mediated loop by forming a series of intermediates including Li2NH, lithium zinc intermetallic compounds (LiZnx), and a ternary metal nitride (LiZnN). LiZnN together with Li2NH functions as nitrogen carrier in the Zn−LiH−Li2NH‐mediated CLAS. Because of these properties, the kinetics of N2 fixation is significantly enhanced with a reduction in apparent activation energy from 102 kJ mol−1 to 50 kJ mol−1. The ammonia production rate reaches 956 μmol g−1 h−1 at 350 °C, which is 19 times higher than that of the neat LiH−Li2NH‐mediated CLAS.
Conventional and advanced extraction methods of some bioactive compounds with health benefits of food and plant waste: A comprehensive review
Authors: Waseem Muhammad , Majeed Yaqoob , Nadeem Tayyaba , Naqvi Laraib Haider , Khalid Muhammad Arslan , Sajjad Muhammad Muzzammil , Sultan Muhammad , Khan Muhammad Usman , Khayrullin Mars , Shariati Mohammad Ali , Lorenzo Jose Manuel 
Published: July 2023

AbstractFood bioactive compounds have a beneficial biological effect on human health, fending off cancer, cardiovascular disease, metabolic syndrome, and neurodegenerative disease, among other noncommunicable diseases and neurodegenerative disorders. Secondary metabolites like polyphenols, glucosinolates, carotenoids, vitamins, terpenoids, saponins, and fibers have been linked to these health benefits due to their antioxidant, antiatherogenic, anti‐inflammatory, antimicrobial, cardioprotective, and vasodilator properties. This review comprehensively illustrates the extraction of bioactive compounds in food formulations along plant wastes and provides insight into the efficient delivery systems for health‐promoting compounds. There is an insight into how to choose which bioactive to use, how to extract them in a bioavailable state, and how to include and deliver them. Grapes, garlic, sweet potato leaves, cactus pears, beetroot, amaranth, Picea abies bark waste, olive leaves, and black plum are discussed comprehensively in terms of extraction and health benefits. The novel and emerging technologies are discussed in detail, and a comprehensive review and comparison with conventional methods are presented. The significant health benefits associated with bioactive compounds are also discussed.
Construction System Failures: Frame Notation of Project Pathogens and their Propagation Across Time and System Hierarchy
Authors: Igarashi Takaharu , Marais Karen 
Published: July 2023

AbstractA construction system is an organizational and technological system that produces buildings or civil engineering structures for human use by fabricating and installing materials into an integrated structure according to design specifications. Failures of such construction systems materialize in various forms, including defective design, rework, and dysfunctional building systems. Frequent accidents and building defects in the construction sector clearly indicate that our society still needs to improve the safety of construction systems. Research studies on how major accidents and minor defects occur are often conducted in isolation by different researchers, and existing system safety concepts and frameworks are not necessarily suited to handling the dynamic nature of temporary multiple organizations (TMOs)—a feature that characterizes the uniqueness of construction projects. We need a framework that can better describe failures specific to construction, and capture the wide spectrum of these failures. Here, we build on concepts from system safety research to develop a graphical notation with “frames” and system hierarchy as the main components to illustrate how pathogens are generated and propagated by defective processes and end up embedded in the physical structure.
Automatic Text Classification of PDF Documents using NLP Techniques
Authors: Abdoun Nabil , Chami Mohammad 
Published: July 2023

AbstractOne of the regular activities performed by engineers during the design and development of the technical systems is to determine which sentences in a PDF specification document represent a requirement, functional architecture, design solution, variability, or other types of systems engineering (SE) data. Extracting such data from these PDF documents and transferring it into system model elements is still performed manually, requires high effort, and is error prone. Hereby, automatic extraction and classification of such SE data has a great potential, but it is still relatively scarce and a challenging task for engineers working with large PDF specification documents. One solution is to follow a suitable writing formulation which provide an immediate and easy way to classify and analyze the PDF documents. However, such formulations are not always followed strictly. As part of our work towards adopting Artificial Intelligence (AI) for Model‐Based Systems Engineering (MBSE), we have been researching the data extraction and data classification topics from PDF files in order to transfer it to system models elements. In this paper, we present the early status of a solution based on AI that uses Natural Language Processing (NLP) techniques to label the SE data existing in PDF files, extract them, and classify them into predefined classes.
A Population-Based Registry Study of Extended Bisphosphonate Use: Minimal Shift After Landmark Publications About Shorter Treatment Duration
Authors: Kline Gregory A. , Morin Suzanne N. , Lix Lisa M. , Leslie William D. 
Published: July 2023

ABSTRACT
Optimal duration of bisphosphonate therapy was unknown until the FLEX study was published in 2006 showing a 5-year course to be adequate for most women. In 2008, a link between long-term bisphosphonate and atypical femoral fractures was reported and confirmed in later studies. We hypothesized these landmark observations should have led to a decrease in use of bisphosphonates for &gt;5 or 10 years, from 2010 onward. The Manitoba Bone Mineral Density (BMD) Registry with linkage to provincial pharmacy data was used to determine the percentage of long- and very long-term bisphosphonate users from therapy start. The cohort comprised women aged &gt;50 years with BMD between 1995 and 2018 with oral bisphosphonate first prescribed for &gt;90 days with adherence &gt;75% in the first year. For each calendar year of continued therapy, the percentage of patients and medication possession rate was tabulated. The percentage of users beyond 5 years was compared among patients who started therapy in 1998–2004 (those taking 5 years of therapy still finish before 2010) versus 2005–2012 (all new therapy starts overlap 2010 in those taking ≥5 years of treatment). The cohort included 2991 women with mean follow-up 8.8 (1.3) years, 64.9% of whom took continuous oral bisphosphonate for &gt;5 years and 41.9% for &gt;10 years. In the earlier versus later era, there were 74.4% versus 70.2% who completed 5 years. With respect to longer treatment, there were 68.0% and 60.5% of patients treated for 6 or more years (p &lt; 0.0001) and 46.6% versus 33.5% treated for &gt;10 years (p = 0.08). Medication possession rate was &gt;79% in every year of therapy. Landmark studies leading to more limited bisphosphonate courses may have slightly reduced longer-term treatment, but up to one-third of adherent patients in the modern era still receive continuous bisphosphonate therapy for &gt;10 years. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
Donors' giving decisions toward nonprofit commercialization: Do commercial form and intensity matter?
Authors: Hung ChiaKo , Suykens Ben 
Published: July 2023

AbstractCommercialization is an established yet contested practice in the nonprofit sphere. Whereas proponents point to increased financial stability, others warn about crowding out of individual donations. This ambiguity raises the question: Under which configuration is nonprofit commercialization (un)likely to uphold the promise of financial stability? Drawing on institutional theory, we conduct a survey experiment with U.S.‐based individuals (N = 1031) to examine the impact of nonprofit commercialization form (i.e., commercialization of core/ancillary activities) and intensity on individual donation likelihood. Contrary to our theoretical expectations, we find that individual donors (a) prefer commercial ancillary activities over commercial core activities, and (b) are not negatively affected by high levels of commercial income. This study advances our understanding of how nonprofit commercialization affects donors' giving likelihood. This study also offers guidance to nonprofit practitioners on how to commercialize for better financial health.