bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Normal Weight Obesity and Normal Weight Central Obesity is Associated with Geriatric Syndromes in Hospitalized Older Adults
Authors: Nascimento Stephany Beatriz do , Santos Roana Carolina Bezerra dos , Santos Letícia Sabino , Mendes Taynara de Sousa Rego , Pereira Jarson Pedro da Costa , LEMOS MARIA CONCEIÇÃO CHAVES , PINHO CLAUDIA PORTO SABINO 
Published: August 2023

Abstract
Purpose. To evaluate the prevalence of Normal Weight Obesity (NWO) and Normal Weight Central Obesity (NWCO) and its associated factors in hospitalized older adults.
Methods. This is a cross-sectional study involving older patients at a University Hospital in Northeastern of Brazil. The NWO was determined by the coexistence of normal BMI (18.5 – 25kg/m2) and high fat percentage (>33.5% for men and >42.8% for women). The NWCO was determined by the coexistence of normal BMI and a very increased waist circumference (> 102cm for men and > 88cm for women). Demographic data, clinical, geriatric, behavior and nutritional aspects were also collected.
Results. The prevalence of NWO was 8% and NWCO was 7.4%. NWO was associated to weight loss (p=0.006), calf circumference (p<0.001), low muscle mass (p<0.001) and sarcopenia (p<0.001). The frequency of NWCO was higher in women (p<0.001), also in those who presented weight loss (p=0.04), in patients with lower calf circumference (p<0.001), low muscle mass (p<0.001), low muscle strength (p=0,018), in sarcopenic (p<0.001), in fragile (p=0.049) and those with functional dependency (p=0,004).
Conclusion. The risk factors associated with NWO were weight loss >5%, low muscle mass and sarcopenia. The risk factors to NWCO were sex (women), weight loss > 5%, functional dependency, low muscle mass, low muscle strength, sarcopenia and frailty.
Sentiment Analysis Using Multinomial LR-LSTM Model
Authors: Rani Seema , Boora Jaibhagwan , Kumar Sanjeev , Chaba Yogesh , Godara Sunila , Noliya Amandeep , Sindhu Sumit 
Published: August 2023

Abstract
Sentiment analysis (SA) refers to a technique utilized to ascertain the emotional state conveyed in information or text. It involves categorizing the text into three classes: positive, negative, or neutral. For instance, when someone says "the aqi of the city is good," they are expressing a positive opinion about the aqi of a specific place, while the statement "the aqi is bad" reflects the opposite. The introduction of social media increased the amount of content on the internet of sentiment data. Users on various social media platforms have been able to offer their opinions on various products, services, etc. These opinions are often expressed on social media in the form of movie reviews, product reviews, user comments, posts, etc. In light of this context, one of the captivating research areas in Natural Language Processing (NLP) is Twitter sentiment analysis. The paper proposes a stacked Multinomial-LR-LSTM model for the classification of tweets into three classes. Tweets are re-annotated using Text Blob. Twitter Sentiment dataset was used for experiments with accuracy of 97%.
A Study to Explore the Substance Basis and Mechanism of Action of the Potential Intestinal-Hepatic-Brain Toxicity of Densefruit Pittany Root-Bark Based on Toxicological Evidence Chain (TEC)
Authors: Xu Xiaomin , Sun Huijuan , Wang Yu , Chen Pingping , Hu Wenkai , Wo Jiameixue , Jia Suxia , Liu Sujie , Lu Fang , Liu Shumin 
Published: August 2023

Abstract
Background Densefruit pittany root-bark is derived from the dried root bark of rutaceae Baixian, a traditional Chinese medicine widely used to treat eczema, psoriasis, and other skin diseases in China. However, in recent years, there have been an increasing number of reports about its negative effects. The potential toxic components and targets of densefruit pittany root-bark intestinal-liver-brain toxicity were screened in this study using pharmacochemistry and network drug/toxicology, molecular docking and molecular dynamics simulation, and were verified by evidence of adverse outcome (AOE).Methods HPLC was used to characterise the densefruit pittany root-bark.TCMSP, TCM-ID, TCM@Taiwan, and CTD databases are used to filter Densefruit pittany root-bark. PharmMapper, SwissTargetPrediction, GeneCards, DisGeNET, and OMIM databases were used to predict the targets of Dense Fruit Root-Bark-induced intestinal-liver-brain tissue damage, and the intersecting targets were chosen for PPI protein interaction analysis, KEGG pathway analysis, and GO enrichment analysis. To depict the core regulatory network, a "drug-compound-toxic target-pathway" map was created using Cytoscape software. The binding affinity and reliability were investigated using molecular docking and molecular dynamics simulation. Finally, HPLC, HE staining, immunohistochemistry, and WB were used to confirm AOE.Results Three compounds in densefruit pittany root-bark were tested, and 125 targets were found to be related to the intestinal-liver-brain toxicity caused by Dense fruit pittance root-bark. The primary targets, according to PPI network analysis, were AKT1, JUN, RELA, SRC, and TP53.Furthermore, GO/KEGG enrichment analysis revealed that densefruit pittany root-bark may modulate Lipid and atherosclerosis, fluid shear stress and atherosclerosis, and the TNF signalling pathway to cause intestinal-liver-brain tissue injury. According to the "herb-compound-toxic target-pathway-organ damage" network, dictamine, obakunone, and fraxinone may be therapeutic or main toxic compounds. Molecular docking and molecular dynamics simulation results show that the core compound has a high affinity for the target.Conclusion This study clarified the mechanism of densefruit pittany root-bark-induced intestinal-liver-brain toxicity, which was the first study on the toxicity of densefruit pittany root-bark based on the concept of TEC, and provided a reference for future research on the toxicity mechanism of densefruit pittany root-bark. However, further experimental validation is required before using densefruit pittany root-bark in clinical practise.
Chromosomal Microarray Analysis for Prenatal Diagnosis of Uniparental Disomy: A Retrospective Study
Authors: xu chenxia , Li Miaoyuan , Gu Tiancai , Xie Fenghua , Zhang Yanfang , Wang Degang , Peng Jianming 
Published: August 2023

Abstract
Background: Chromosomal microarray analysis (CMA) is a valuable tool in prenatal diagnosis for detecting chromosome uniparental disomy (UPD). This retrospective study examines fetuses undergoing invasive prenatal diagnosis through Affymetrix CytoScan 750K array analysis. We evaluated both chromosome G-banding karyotyping data and CMA results from 2007 cases subjected to amniocentesis.
Results: The detection rate of regions of homozygosity (ROH) ≥10 Mb was 1.8% (33/2007), with chromosome 11 being the most frequently implicated (17.1%, 6/33). CMA successfully identified three cases of UPD stemming from imprinted genes.
Conclusion: The combination of karyotyping and CMA can provide a more accurate prenatal genetic diagnosis. CMA proves effective in identifying ROH and in averting the birth of children afflicted with imprinting diseases.
Seasonal distribution, source identification, health and eco-toxicological risk assessment of PAHs in water and sediment from the Danube River in Hungary
Authors: Grmasha Ruqayah Ali , Stenger-Kovács Csilla , Al-sareji Osamah J. , Al-Juboori Raed A. , Meiczinger Mónika , Andredaki Manolia , Idowu Ibijoke A. , Hashim Khalid S. 
Published: August 2023

Abstract
The Danube is one of the largest transboundary rivers word-wide, having several tributaries. The discharges from industrial activities and wastewater treatment facilities affect the river's aquatic environment. These discharges pose a serious risk to aquatic life by degrading the water and sediment quality. Therefore, 16 Polycyclic Aromatic Hydrocarbons (PAHs) compounds in six different locations were examined along the river over 12 months to investigate the temporal and special variations of the compounds in water and sediment. The findings highlighted a broad variance range in PAHs concentration in water within a year, ranging from 224.85 ng/L in summer to 365.87 ng/L in winter, whereas PAHs in sediment samples recorded values ranging from 316.72 ng/g in dry weight in summer to 422.98 ng/g in dry weight in winter. The overall results indicate that the putative anthropogenic sources of PAHs were of pyrolytic and pyrogenic origin; with pyrogenic sources being more prominent. Generally, except for Acenaphthylene and Fluorene concentrations, the eco-toxicological concerns for the aquatic environment of the Danube River do not pose a significant threat. In addition, the combined impact of the 16 PAHs pollutants in sediments suggests a low chance for negative biological impacts and low ecological risk. The total ILCR for both children and adults is more than 1/104 in all seasons, with the highest values recorded in spring followed by winter time, which becomes a matter of urgency.
Stick Roller: A Case Study on Efficiently Learning Precise Tactile Dynamics for In-hand Manipulation
Authors: Du Yipai , Wang Michael Yu , Lian Wenzhao , She Yu 
Published: August 2023

Abstract
In-hand manipulation is challenging in robotics due to the intricate contact dynamics and high degrees of control freedom. Precise manipulation with high accuracy often requires tactile perception, which adds further complexity to the system. This paper addresses these challenges in perception and control and proposes a framework for learning high-resolution tactile dynamics on real hardware that is feasible and scalable. Specifically, we use a case study on manipulating a small stick using the Allegro hand equipped with the Digit vision-based tactile sensor to demonstrate the framework's effectiveness. The framework includes an action space reduction module, tactile perception module, and learning with uncertainty module, all designed to operate in low data regimes. With minimal manually collected data, our learned contact dynamics model achieves grasp stability, sub-millimeter precision, and zero-shot generalizability across novel objects. The proposed framework demonstrates promising results for enabling precise in-hand manipulation with tactile feedback on real hardware.
Cell structure of epiphytic orchids’ root cortex and exodermis shape fungal colonization
Authors: Bibikov Nikita , Voronina Elena , Eskov Alen , Ignatov Mikhael 
Published: August 2023

Abstract
Epiphytic orchids unlike terrestrial species possess water storage elements as an adaptation to dry habitats. Two types of structures are present in roots and thus involved in interaction with mycorrhizal fungi that obligately colonize roots. Lignified water storage cells (WSC) are situated in cortex and perform the function of water storage. Among lignified exodermis cells thin-walled passage cells (PC) are present. These elements are necessary for water exchange between cortex and the environment. In this study we measure colonization rate of water storage cells and passage cells and discuss how these two functions interact in orchid root. We show that water storage cells may be colonized but less favorably than thin-walled cortex cells and support exiting data that passage cells are the only way for fungal hyphae to pass through exodermis. This evidence provokes discussion on water uptake and mycorrhiza of epiphytic orchids.
Simultaneous multiple target detection platform based on vertical flow immunoassay
Authors: Yong Taek , Kim Dami , Kim Sanghyo 
Published: August 2023

Abstract

In general, vertical flow assay (VFA) has a disadvantage of requiring a complex analysis process that involves manually injecting various reagents (target analyte, washing buffer, detection conjugate, etc.) sequentially. However, in this study, we have developed an innovative paper-based VFA device that replaces the complex analysis process with one-step and enables the detection of multiple targets. The fabrication process of the multi-target detection VFA device is as follows: preparation and pre-treatment of the strip materials, design of strip cartridge, design of the multiple detection VFA device, optimization experiments for strip sample flow rates, determination of device analysis time, determination of device limit of detection (LOD), multiple target signal uniformity experiment, IgG and CRP antigen-antibody multiple detection experiment, and data extraction and analysis method. The use of paper-based materials enables the device to be produced at cost-effective, and cartridge production allowed for uniform array formation. IgG and CRP are used to evaluate the performance of the device as common biomarkers. To validate multiple target detection capability of the VFA device proposed in this study, two types of antigens-antibodies (Human IgG and Human CRP) were employed. In conclusion, the VFA device proposed in this study consists of a one-step analysis process, and it has been confirmed that it can detect multiple targets simultaneously.
Loss of CYP2D6 sensitizes hepatocellular carcinomas and neuroblastomas to talazoparib
Authors: Sjöblom Tobias , Zhang Xiaonan , Rameika Natallia , Zhong Lei , Rendo Verónica , Kundu Snehangshu , Nuciforo Sandro , Dupuis Jordan , Azhar Muhammad Al , Tsiara Ioanna , Seeburger Pauline , Nassralla Shahed Al , Ljungström Viktor , Svensson Richard , Stoimenov Ivaylo , Artursson Per , Heim Markus , Globisch Daniel 
Published: August 2023

Abstract
Cancers often have reduced allelic diversity because of loss of heterozygosity (LOH). Therefore, tumors arising in patients heterozygous for a functional and a loss-of-functon(LoF) allele may lose the functional allele, rendering them sensitive to allele-specific therapies. To discover such alleles, we mined the 1000 Genomes dataset for SNVs causing protein truncation through base substitution, indels or splice site disruptions, resulting in 60 LoF variants in 60 genes. The LoF splice site variant rs3892097 in CYP2D6 was selected as it resides in a genomic region undergoing LOH in different tumor types, is highly polymorphic with over 135 allelic variants, and metabolizes ~25% of clinically used drugs. We generated cell systems and screened anticancer agents in clinical use or in clinical trials for differential toxicity, and Talazoparib and MK-8776 were shown to exhibit consistent cytotoxicity against hepatocellular carcinoma and MYCN-amplified neuroblastoma cells with low CYP2D6 activity in 2D and 3D culture. Moreover, Talazoparib displayed CYP2D6 genotype dependent effects on primary hepatocellular carcinoma organoids. These findings support a new therapeutic strategy targeting LoF variants of drug-metabolizing enzymes, enabling anticancer drug selection for precision medicine.
Some New Properties of Hyperbolic K-fibonacci and K-lucas octonions
Authors: Godase A. D. 
Published: August 2023

Abstract
The aim of this paper is to establish some novel identities for hyperbolic k-Fibonacci octonions and k-Lucas octonions. We prove these properties using the identities of k-Fibonacci and k-Lucas numbers, which we determined previously. Mathematics Subject Classification (2010). Primary 11B39; Secondary 11B37, 11B52.
Multimodal Imaging of Retinal Toxicity in a Patient Taking Axitinib
Authors: Çomçalı Sebile , Coşkun Çiğdem , Çavdarlı Cemal , Alp Mehmet Numan 
Published: August 2023

Abstract
Background: Axitinib is a selective inhibitor of vascular endothelial growth factor receptors.
Case presentation: A forty-five years old female presented with blurred vision who had been taking 7 mg of Axitinib bid for 5 months. Initial best corrected visual acuity (BCVA) was 20/32 at the right and counting fingers at the left eye. Funduscopic examination revealed bilaterally widespread intraretinal hemorrhages, cotton-wool spots, and hard exudates with a star-like appearance at the macula. The optical coherence tomography revealed central macular edema. There was hyperreflective edema in the inner layers, exudates in the middle retinal layers and subfoveal subretinal fluid. Fundus fluorescein angiography revealed localized ischaemic findings in the early phase and multifocal perivascular ink-blot fluorescein leakage in the middle and late phases.
Conclusions: Axitinib treatment was discontinued immediately, and at the 3-month of follow-up, the macular edema and fundus findings improved with final BCVA 20/20 at the right, and 20/32 at the left eye.
Contribution of 18F-FDG PET/MR Imaging in Detection of Peritoneal Carcinomatosis in Patients with Ovarian Cancer
Authors: Baltacioglu Muhammet Halil , Soydal Cigdem , Araz Mine , Oz Digdem Kuru , Taskin Salih , Kucuk Nuriye Ozlem , Erden Gul Ayse , Elhan Atilla Halil 
Published: August 2023

Abstract
Purpose: Presence of peritoneal metastasis in ovarian cancer is one of the most important factors affecting the prognosis of the disease. In this study, it was aimed to compare the diagnostic performances of 18F-FDG PET/CT and 18F-FDG PET/MR imaging for the detection of peritoneal recurrence in patients with ovarian cancer.
Material-Methods: 66 images of 45 patients with ovarian cancer who had elevated serum Ca-125 levels at post-operative follow-up and were referred to 18F-FDG PET/CT for restaging of disease were prospectively recruited in the study. All patients underwent whole body 18F-FDG PET/CT followed by whole abdomen PET/MRI. The peritoneal carcinomatosis index (PCI) was calculated for each patient in both imaging modalities. PET/CT and PET/MRI were evaluated for the presence and localization of peritoneal recurrences for each modality.
Results: In study-based analysis; PET/MRI was positive in 49 studies (74%), while PET/CT was positive in 34 studies (51%) (p=0.001). The total number of regions with peritoneal uptake was 144 in PET/CT and 243 in PET/MRI (p<0.001). The median PCI was 1.5 in PET/CT and 4 in PET/MRI (p<0.001). In the evaluation of liver-spleen capsule metastases, the detection rate was 17/66 (26%) for PET/CT and 30/66 (45%) for PET/MRI (p=0.008). Distant organ metastases were detected on PET/MR in 3 studies where PET/CT was negative. In our study, additional findings obtained from PET/MRI changed the treatment strategy in 15 patients.
Conclusion: Peritoneal metastasis detection rate is higher in PET/MRI than PET/CT in patients with recurrent ovarian cancer with elevated Ca-125 levels. In addition, PET/MRI is useful in the evaluation of the liver-spleen capsule metastases. PET/MRI findings can help to selection of appropriate treatment strategy in recurrent ovarian cancer patients.
Toll-like receptor 9-positive plasmacytoid dendritic cells promote Th17 immune responses in oral lichen planus stimulated by epithelium-derived cathepsin K
Authors: Miyahara Yuka , Hu Chen , Moriyama Masafumi , Mochizuki Keita , Kaneko Naoki , Haque Rafiul ASM , Chinju Akira , Kai Kazuki , Sakamoto Mizuki , Kakizoe-Ishiguro Noriko , Yamauchi Masaki , Ogata Kenichi , Kiyoshima Tamotsu , Kawano Shintaro , Nakamura Seiji 
Published: August 2023

Abstract
Oral lichen planus (OLP) is a chronic inflammatory disease associated with T cell infiltration. The crosstalk between oral epithelium and mucosal T cells was considered to play an important role in the pathogenesis of OLP. Here, we selectively extracted the normal and lesional epithelium (LE) of buccal mucosa specimens from three patients with OLP by laser capture microdissection due to identify the pathogenic factors. Cathepsin K (CTSK) was identified as one of common upregulated genes in the LE by DNA microarray. Immunohistochemically, CTSK was distinctly detected in and around the LE, while it was rarely seen in the NE. Recent studies showed that CTSK enhanced Toll-like receptor 9 (TLR9) signaling in antigen-presenting cells, leading to Th17 cell differentiation. TLR9 expression mainly co-localized with CD123+ plasmacytoid dendritic cells (pDCs). The number of RORγt-positive cells correlated with that of CTSK-positive cells in OLP tissues. CD123+ pDCs induced the production of Th17-related cytokines (IL-6, IL-23, and TGF-β) upon stimulation with TLR9 agonist CpG DNA. Moreover, single cell RNA-sequencing analysis revealed that TLR9-positive pDCs enhanced in genes associated with Th17 cell differentiation in comparison with TLR9-negative pDCs. CTSK may induce Th17-related production of CD123+ pDCs via TLR9 signaling to promote the pathogenesis of OLP.
An Extended Sparse Model for Blind Image Deburring
Authors: Ge Xianyu , Liu Jing , Hu Dandan , Tan Jieqing 
Published: August 2023

Abstract
Blind image deburring is a classical ill-posed problem that usually requires constraints on the clean image, the blur kernel, and noise to make it well-posed. Recently, a simple yet effective sparse norm le is proposed, which adds two widely-adopted sparse norms, i.e., l0 and l1. By using le to regularize the gradients of the clean image, and l2 + ∇le as the noise fitting function, an enhanced sparse model for blind image deburring is established and achieves surprisingly attractive results. In this paper, inspired by the facts that the gradients of a natural image tend to obey a heavy-tailed distribution, and the noise exhibits spatial random-ness, we propose a more flexible model called the extended sparse model which can take the enhanced sparse model as a special case. Specifically, for the image gradients, we suggest a improved sparse norm lP , which is developed from l0 and lp(0 < p ≤ 1). Furthermore, we constrain the second-order derivative of noise to boost the percentage of high-frequencies in the fidelity such that the recovery focuses more on high-frequencies that are erased in the blurry image. Based on the half-quadratic splitting method and a variant of the generalized iterated shrinkage algorithm (GISA), we provide an effective optimization scheme for the overall model. Extensive evaluations of benchmark datasets and real images indicate the superiority of the proposed method against state-of-the-art deburring algorithms.
Comparison of daily 400 and 600 units of vitamin D in prevention of osteopenia of prematurity in infants with gestational age of less than and equal to 32 weeks
Authors: Barekatain Behzad , Hamidipour Shima , Badiei Zohreh , Farghadani Maryam 
Published: August 2023

Abstract
Background
Use of vitamin D in premature infants is one of the important preventive factors for Osteopenia of prematurity but there are conflicting results on the appropriate doses, so this study aimed to compare the dose of 400 and 600 units vitamin D in the prevention of osteopenia of prematurity in infants with gestational age ≤ 32 weeks.
Methods
This clinical trial study was conducted on 108 premature infants divided into two groups of 54 with gestational age of ≤ 32 weeks born between 2020-2021 in Shahid Beheshti and Al-Zahrai hospitals in Isfahan. In the first group, daily vitamin D was 400 units from the 7th day of birth, and in the second group, it was 600 units. At the age of 5 weeks, levels of calcium, phosphorus, alkaline phosphatase and vitamin D were evaluated. If the alkaline phosphatase level was above 1000, the wrist radiography was requested.
Also, the baby was examined for clinical symptoms of rickets at the age of 5 weeks. The data were analyzed by SPSS software version 26 and P-value<0.05 was considered significant.
Results
In the present study, there was no significant difference between the level of alkaline phosphatase in the two groups (p=0.596), but the level of vitamin D was significantly higher in 600 units group (p<0.001). The level of calcium was higher in 400 units group, but this difference was slightly significant (p=0.062). The level of phosphorus in 600 units group was higher than the 400 units, and the difference was slightly significant (P=0.062).
Conclusion
The present study showed that daily 600 and 400 units of vitamin D in infants with gestational age of ≤ 32 weeks had no effect on the incidence of clinical symptoms and radiological findings of rickets at the age of 5 weeks.