bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing of New Technologies Driving Advances in Precision Agriculture to optimise inputs and reduce environmental footprint
Authors: Glass Charles Richard , Egea Gonzalez Francisco J 
Published: February 2023

Technological advances in the agri-tech sector offer the opportunity for food production systems to contribute to achieving global policy aims such as achieving net zero carbon systems and reducing environmental footprint through eliminating harmful emissions and increasing biodiversity. A range of sensors can detect crop health and stress due to biotic and abiotic threats, often with an early detection which permits appropriate action to be taken before crop yield is affected or pest and disease pressure cannot be controlled without the use of synthetic pesticides. Detection technology uses imaging techniques, often beyond the visible spectrum, detection of volatile compounds using e-nose techniques and real time molecular diagnostic techniques to identify plant pathogens collected in air samples. The data generated by such technologies relies on connectivity of the hardware and subsequent analytical processes to provide growers with temporal and spatial information. It is possible to identify plant locations with great accuracy, even with satellite systems, which permits precision application of crop inputs, such as fertilisers and pesticides, directly to the plant or crop area as required. Spray application techniques can now treat individual plants, both crop and weeds, using data acquired to control the flow to individual nozzles
Hydraulic sand test and analysis based on sound emission data and fracture surface
Authors: Zhang Shuhui 
Published: February 2023

Abstract
Due to the extremely low permeability of shale reservoirs, large-scale reservoir fracturing is required. Hydraulic fracturing is one of the most important technologies in shale gas exploration and development. In this paper, the acoustic emission energy and the number of location and fracture surface morphology of specimens before and after fracture are studied through hydraulic sand fracturing test. The test results show that: (1) the energy ratio obtained during hydraulic fracturing without proppant is the smallest, and increasing the confining pressure, as well as reducing the displacement and viscosity of the fracturing fluid will cause the energy ratio to decrease. From the perspective of acoustic emission energy, the proppant It plays an important role in the generation of fractures during hydraulic sand fracturing; (2) when the confining pressure increases, the number of shale specimens before and after rupture is the largest, but the total number of locating events is smaller than when the sanding ratio is increased; when there is no proppant hydraulic fracturing, the number of specimens before and after the rupture is the largest And the total number reached the minimum, indicating that the proppant can play an important role in the hydraulic sand fracturing test; (3) the sand is relatively large, the specific surface and standard deviation both reach the maximum, indicating that the fracture surface roughness is the largest under this test condition, and the fracturing effect is the best, but the specific surface and standard deviation are the minimum when fracturing without proppant, Indicating that the fracture surface fracturing effect is the worst at this time.
Utilization of reeds to sequester Ni and/or Cu from wastewater and to produce valuable products
Authors: vudang Ken , Duran Valeria , Brdecka Michael , Seigerroth Julia , Jang Ben , guo lin 
Published: February 2023

Abstract

This project evaluated the potential of common reed to uptake Ni and Cu from wastewater and then investigated the feasibility of converting the resulted biomass to valuable products. Common reeds were grown in 25, 50, or 75 ppm Ni and/or Cu solutions for 4 weeks to evaluate its potential to uptake metals followed by converting the contaminated biomass to valuable products by hydrothermal conversion (HTC). The higher concentration of metals in solution, the more metals accumulated in plants. The amounts of metals accumulated in different parts of reeds were root > stem > rhizome ~ leave. Roots and stems treated with binary metals contained less Ni/Cu than those cultured in single metal. The yields of bio-oils and hydrochars from reeds treated with different levels of metals were similar. About 6%-10% of bio-oil, 50%-60% of hydrochars were produced. The results suggest that metal accumulated in reeds does not affect the utilization of contaminated reeds via HTC. About 0.1–1.5% of Cu and/or Ni were transmitted from contaminated reeds to bio-oils after HTC at 250°C.
Systematic pan-cancer analysis identifies 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) as a biomarker of tumor invasion and metastasis, immunity, and prognosis
Authors: Liu Dandan , Liu Yingying , Zhang Chaoyang , Zhang Jingting , Xu Guo-Tong 
Published: February 2023

Abstract
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a potent regulator of glycolysis in tumor cells, and high PFKFB3 expression is significantly associated with the invasion and metastasis of several tumors. However, there are no comprehensive reports on whether PFKFB3 promotes tumor invasion and its mechanism in different cancer types. In addition, there are no systematic reports on the effect of PFKFB3 on the stemness and immune infiltration ability of different tumors and on the survival rate of patients. Herein, we conducted a pan-cancer analysis of PFKFB3 with the aim of exploring the key cellular and molecular mechanisms regulating the pathogenesis and progression of human cancers, and propose potential strategies for the prevention and treatment of cancer by targeting PFKFB3. Using bioinformatics analysis and integrative exploration from the Gene Expression Omnibus (GEO) and Cancer Genome Atlas (TCGA) databases, the differential expression of PFKFB3 or phosphorylated PFKFB3 and its correlation with tumor staging and stemness, survival prognosis, and immune invasion were extensively analyzed. The analysis showed differential expression of PFKFB3 in normal tissues and in various cancers. Increased PFKFB3 expression is positively correlated with the invasive ability and immune infiltration of 31 cancers and significantly affects the staging, stemness, prognosis, and survival rate of several cancers. Alterations in phosphorylated PFKFB3 and RNA modifications are also involved in the development and progression of various cancers. PFKFB3 is involved in multiple protein interactions and has complex molecular functions, such as ATP/ADP metabolic and glycolytic processes. Furthermore, PFKFB3 has a high mutation frequency, especially amplification, in multiple tumors. These findings highlight the significance of PFKFB3 in cancer progression, which might serve as a surrogate pan-cancer biomarker to predict the progression and outcome of cancers, as well as the invasion and immune infiltration of different cancers. Ethical compliance: This study did not involve any patient or animal samples and was approved by the academic committee of Tongji University.
An Improved Deep Neural Network Based on Combination of GRU and Auto Encoder for Sentiment Analysis
Authors: Zulqarnain Muhammad , Alsaedi Ahmed Khalaf Zager , Sheikh Rubab , Javid Irfan , Ahmad Maqsood , Ullah Ubaid 
Published: February 2023

Abstract
Sentiment analysis is a particularly common task for determining user thoughts and has been widely used in Natural Language Processing (NLP) applications. Gated Recurrent Unit (GRU) was already effectively integrated into the NLP process with comparatively excellent results. GRU networks outperform traditional recurrent neural networks in sequential learning tasks and solve gradient vanishing and explosion limitation of RNNs. In this paper, a novel approach as known Normalize Auto-Encoded GRU (NAE-GRU) was proposed, in order to reduce dimensionality of data through an Auto-Encoder and enhance the performance of the proposed approach by using batch normalization. Empirically, we demonstrate that the proposed model, with minor hyperparameters modification, and statistic vectors optimization, achieves outstanding sentiment classification performance on benchmark datasets. The developed NAE-GRU approach outperforms than other different traditional methods in terms of accuracy and convergence rate. The experimental results have showed that the developed approach accomplished excellent performance than existing approaches on four benchmark datasets included, Amazon review, Yelp review, IMDB and SSTb. The experimental results have showed that the developed approach is proficient to reduce the loss function, and capture long-term relationships with an effective design that achieved excellent results as compared state-of-the-art methods.
Analysis and prediction of surface topography characteristics and influence factors of tool passive vibration in milling process
Authors: Zhang Wei , Su Peibin , Zhang Lei , Bai Fengsong 
Published: February 2023

Abstract
The surface topography of the work-piece after machining has an important influence on the service performance, and the passive vibration of the tool will occur due to the influence of the milling force during the machining process. This paper focuses on the influence of the milling parameters and the passive vibration of the tool on the formation process of the surface topography. Firstly, the forming mechanism of the surface topography when the tool is passively vibrated is studied, and the cutting edge motion trajectory model considering the milling parameters and the tool passive vibration is established; The influence of milling parameters on surface topography with or without tool passive vibration is analyzed through experiments and simulations; The prediction models of maximum height Sz and three-dimensional arithmetic mean height Sa of surface topography are established by least squares support vector machine. The improved PSO algorithm is used to search the optimal solution of the kernel width coefficient and regularization parameters in the least squares support vector machine, and the program of the improved PSO-LSSVM prediction model is compiled. The prediction model proposed by error verification can provide a theoretical basis for the selection of actual milling processing parameters.
The Effect of Cytotoxic CD8+ T-Cells Secretory Proteins on Hypoxic Pancreatic Cancer Cells
Authors: Abdo Eiman , Ismail Mohammad A. , Hadidi Sabal Al , Al-Mrahleh Mairvat , Zihlif Malik , Ababneh Nidaa A 
Published: February 2023

Abstract
Background: Pancreatic cancer is a highly progressive cancer with limited effective treatment. The tumor microenvironment in pancreatic cancer is aggressive and severely hypoxic with a high immunosuppressive effect. This has raised the attention to understanding the pancreatic cancer microenvironment and the interaction between pancreatic cancer cells and cytotoxic T-cells.
Objective: This study aimed to investigate the crosstalk between hypoxic pancreatic cancer cells (PANC-1) and cytotoxic CD8+ T-cells.
Methods: Pancreatic cancer cells (PANC-1) were exposed to 20 cycles of chronic hypoxic conditions for 72 hours followed by a re-oxygenation period for 24 hours. On cycles 10 and 20, PANC1 hypoxic conditioned media (CM) were harvested and the hypoxic PANC-1 cells were co-cultured with the activated cytotoxic CD8+ T-cells or with CD8+ T-cells CM. CD8+ T-cells CM was collected after 5 days of cell activation using anti-CD3/CD28 antibodies and interleukin-2 (IL-2). On the other hand, CD8+ T-cells were activated for 72 hours, and then cultured with the hypoxic PANC-1 CM.
Results: Hypoxic PANC-1 cells showed a significant increase in resistance to the lytic effect of either CD8+ T-cells coculture or CD8+ T-cells CM treatment when compared with normoxic PANC-1 cells. A significant decrease in TNF-α and IFN-γ levels was also detected. Additionally, a significant increase in IL-6, P53 and TNF-α gene expression levels was observed in PANC-1 cells treated with CD8+ T-cells CM. Moreover, IL-6 gene expression level showed a significant difference between hypoxic and normoxic PANC-1 cells. Furthermore, CD8+ T-cells proliferation and cytokines production were significantly higher in cells cultured with PANC-1 CM. However, no significant differences were observed after treatment with either hypoxic or normoxic PANC-1 CM.
Conclusion: Hypoxia influences PANC-1 cells' sensitivity to cytotoxic CD8+ T-cells. Several mechanisms of PANC-1 resistance were detected in this study; an increase in IL-6 production and a depletion in TNF-α and IFN-γ levels when co-cultured with PANC-1 cells. In treated PANC-1 cells, an increase in TP53 and TNF-α gene expression were observed. IL-6 activation is one of the mechanisms that may increase the resistance to CD8+ T-cells in hypoxic PANC-1 cells.
Insomnia plays a key role in mental health problems of COVID-19 patients in Square Cabin Hospitals: a network analysis
Authors: Zhang Tian , Li Yijun , Sun Jingjing , Yu Jing , He Wei , Wu Lin , Lin Xinxin , Wang Lingling , Peng Xiyuan , Mao Li , Peng Jiaxi , Fang Peng 
Published: February 2023

Abstract
Background: While the emergence of the Coronavirus Disease 2019 (COVID-19) has greatly affected the mental health and wellbeing of people everywhere, the core symptoms of common syndromes of psychological distress remain unclear, especially among COVID-19 patients who have been quarantined in Square Cabin Hospitals. Using the method of network analysis, the current study explored the relations between stress, depression, anxiety and insomnia symptoms among COVID-19 patients in Shanghai Four-Leaf Clover Cabin Hospital.
Method: The study used an online survey to gauge the mental health issues of COVID-19 patients at Shanghai Four-Leaf Clover Cabin Hospital from April 18 to May 19, 2022. The Perceived Stress Scale, Patient Health Questionnaire, Generalized Anxiety Disorder Scale, and Insomnia Severity Index were used to assess perceived stress symptoms, depressive symptoms, anxiety symptoms, and insomnia symptoms, respectively. The central symptoms and bridge symptoms were determined using a regularized partial correlation network.
Results: A total of 1014 patients was included in this study. Overall, 61.5%, 49.2% , and 56.1% of all patients reported symptoms of depressive, anxiety, and insomnia, respectively. “Distress caused by the sleep difficulties” had the highest expected influence, followed by “Excessive worry”, “Severity of sleep onset”, “Overburden”, “Uncontrollable worry”, “Trouble relaxing”, “Restlessness”. Seven bridge symptoms were identified: “Sad Mood”, “Severity of sleep onset”, “Sleep”, “Motor”, “Feeling afraid”, “Nervousness”, “Appetite”. In addition, significant differences in network global strength were found between women and men.
Conclusions: Psychological distress was prevalent among COVID-19 patients and insomnia symptoms played a key role in the network of psychological distress symptoms. As a result, specific insomnia symptoms should be closely monitored as potential intervention targets in alleviating or preventing common, frequently co-occurring psychiatric syndromes.
Nano-kinematic indicators (Gulf of Aqaba, Saudi Arabia)
Authors: Genovese Alessandro , Fedorik Jakub , Afifi Abdulkader , Bernhard Grasemann 
Published: February 2023

Abstract
Strain and kinematic indicators are frequently investigated to assess the type, magnitude, and orientation of deformation fields. Typically, their analysis ranges from the outcrop to the thin section scale. The present study characterizes the structural and mineralogical development of a phyllosilicate-rich fault gouge from the core of a major strike-slip fault on the eastern margin of the Gulf of Aqaba. We used transmission electron microscopy and focused ion beam techniques to explore shear deformation structures down to the nanoscale. The fault gouge was differentiated at the micron-submicron scale into chlorite-rich and illite-rich bands. The observed nano-kinematic shear sense indicators were SC/SCC’ fabrics in phyllosilicate bands, inclined axial planes in kink-folded illite and chlorite plates, platy hematite clasts inclined against the shear direction, and a σ-type clast system with recrystallized material in strain shadow wings around the clasts. These indicators provide a consistent set of criteria to determine shear sense in phyllosilicate-rich fault gouges.
Genetic polymorphism of the growth hormone gene and their effects on growth metrics in the Assam Hill and Sirohi goats under subtropical climatic condition
Authors: Kumar Rakesh , Govindasamy Kadirvel , Khargharia Gautam , Lyngdoh Erica , Singh Mahak , Das Meena , Singh Vinay , Mishra Vinay 
Published: February 2023

AbstractGrowth hormone (GH) is a gene that regulates milk production, reproduction, and growth in animals. Therefore, the purpose of this study was to identify GH gene variations and their associations with growth metrics in Sirohi and Assam hill goats. We identified two polymorphic loci (GH1-HaeIII & GH2-HaeIII) which were connected to growth attributes in 161 animals of Assam hill (n = 114) and Sirohi (n = 47) goats using the methods of PCR-RFLP. According to PCR-RFLP results, the GH gene's GH1-HaeIII locus contains two alleles (A and B) and two genotypes (AA and AB), whereas the GH2-HaeIII locus contains two alleles (C and D) and two genotypes (CC and CD). In the two goat breeds, the allele frequencies of A and B were 0.36 − 0.28 and 0.64–0.72, respectively, while the frequencies of alleles C and D were 0.71 − 0.70 and 0.29–0.30. The polymorphic loci were demonstrated to be in a state of Hardy-Weinberg disequilibrium in both breeds of goats (P < 0.05). The growth characteristics of the Assam hill goat breed were shown to be correlated with GH gene variations. In both breeds, AB and CD genotypes displayed slightly higher values in most of the morphometric traits compared to AA and CC genotypes; however, only in Assam hill goats body length and chest girth were positively significant (P < 0.05). Hence, the AB and CD genotypes have been proposed as potential markers for improved growth parameters in the breeds that were tested. Therefore, we came to the view that the two variant loci of the GH gene will utilize as marker assisted selection for enhancing growth attributes in goats; however, more research with a bigger sample size is necessary to verify the validity of this conclusion.
Left versus right destroyed lung pneumonectomy:short-term and long-term prognosis and risk factors
Authors: Li YunSong , Wang Heng , Wang Chunmao , Zhang Li , Wang Yuxuan , Bai Zhexin , Yan Dongjie , Liu Fangchao , Ruan Hongyun 
Published: February 2023

Abstract
Aim:
To compare and analyze postoperative short-term and long-term destroyed lung (DL) disease prognosis for patients undergoing left versus right pneumonectomy and to explore related risk factors.
Methods:
Retrospective analysis was conducted of clinical data obtained for 128 DL patients who underwent pneumonectomy in the thoracic surgery department of Beijing Chest Hospital from November 2001 to May 2022. Based on lesion site, cases were divided into two groups: a left pneumonectomy group (104 cases) and right pneumonectomy group (24 cases). Then, postoperative short-term and long-term DL disease clinical features and prognostic factors were analyzed and compared.
Results:
As compared with the left pneumonectomy group, the right pneumonectomy group experienced greater rates of preoperative diabetes and chronic pulmonary aspergillosis (CPA) rates and greater rates of intraoperative blood loss and postoperative respiratory failure. Right pneumonectomy group rates of rehospitalization, tuberculosis recurrence, BPF and empyema were higher than corresponding left pneumonectomy group rates. Results of binary logistic regression analysis revealed that CPA (OR: 5.234, 95% CI: 1.768-15.498) was a key risk factor for secondary respiratory failure, while residual cavity reinfection (OR: 4.402, 95% CI: 1.063-18.241) was a key risk factor for rehospitalization and right pneumonectomy was a key risk factor for tuberculosis recurrence (OR: 4.443, 95% CI: 1.241-15.907) and BPF/thoracic infection (OR: 6.713, 95% CI: 1.212-37.198).
Conclusion:
Patients undergoing right pneumonectomy experience poorer outcomes with regard to short-term postoperative safety and long-term prognosis as compared to left pneumonectomy patients. Furthermore, surgeons should exercise extreme caution when performing pneumonectomies on DL patients with CPA, who are most likely to experience residual cavity reinfection, in order to prevent this postoperative complication.
Evaluation of implementation outcomes of an integrated group postpartum and well-child care model at clinics in Malawi
Authors: Gresh Ashley , Mambulasa Janet , Ngutwa Nellie , Chirwa Ellen , Kapito Esnath , Perrin Nancy , Warren Nicole , Glass Nancy , Patil Crystal L. 
Published: February 2023

Abstract

Background
Persistently elevated rates of maternal and infant mortality and morbidities in Malawi indicate the need for increased quality of maternal and well-child care services. The first-year postpartum sets the stage for long-term health for the childbearing parent and infant. Integrated group postpartum and well-child care may improve maternal and infant health outcomes. The purpose of this study was to examine implementation outcomes for this model of care.
Methods
We used mixed methods to examine implementation outcomes of integrated group postpartum and well-child care. We piloted sessions at three clinics in Blantyre District, Malawi. During each session we evaluated fidelity using a structured observation checklist. At the end of each session, we administered three surveys to health care workers and women participants, the Acceptability of Intervention Measure, the Intervention Appropriateness Measure, and the Feasibility of Intervention Measure. Focus groups were conducted to gain greater understanding of people’s experience with and evaluation of the model.
Results
Forty-one women with their infants participated in group sessions. Nineteen health care workers across the three clinics co-facilitated group sessions, 9 midwives and 10 health surveillance assistants. Each of the 6 sessions was tested once at each clinic for a total of 18 pilot sessions. Both women and health care workers reported group postpartum and well-child care was highly acceptable, appropriate, and feasible across clinics. Fidelity to the group care model was high. During each session as part of structured observation the research team noted common health issues, the most common one among women was high blood pressure and among infants was flu-like symptoms. The most common services received within the group space was family planning and infant vaccinations. Women reported gaining knowledge from health promotion group discussions and activities. There were some challenges implementing group sessions.
Conclusion
We found that clinics in Blantyre District, Malawi were able to implement group postpartum and well-child care with fidelity and that it was highly acceptable, appropriate, and feasible to women and health care workers. Due to these promising results, we recommend future research examine the effectiveness of the model on maternal and child health outcomes.