bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the applicability of methods and tools in process systems engineering for fermentation processes
Authors: Brito Rodrigues de Jesus Alexandre , de Carvalho Miranda Júlio Cesar 
Published: July 2023

AbstractFermentation is the main process for converting substrates into bioproducts such as ethanol, bioplastics, and different foods and drinks. However, there are numerous challenges associated with the fermentation process in bioreactors and many of them can be solved using simulations based on process systems engineering (PSE). This study's objective is the design and assessment of the applicability of simulations of three fermentation processes (alcoholic, lactic, and propanoic) through their kinetic parameters, using the commercial process system engineering platform Aspen Plus, integrated with a chemical kinetics subroutine made as a Fortran User Model for calculating the process balances. The simulations of fermentation models in Aspen Plus were consistent, considering the experimental models available in the literature. In most cases, the residual standard deviation (RSD) (%) obtained was below 10%, which is acceptable for biotechnological processes. Some cases did not represent the literature models due to the limitations of the simulator (thermodynamics and components), linked with the complexity of the model. The applicability of these models within a commercial simulator, although limited, is therefore valid for the design, analysis, and optimization of complex reactional systems, such as fermentation, which implies quick technological advances, especially regarding bioprocesses. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
Application of action observation therapy in stroke rehabilitation: A systematic review
Authors: Zhang Chenping , Li Xiawen , Wang Hongbiao 
Published: July 2023

AbstractBackgroundNumerous studies have described the positive effects of action observation therapy (AOT) on motor recovery among patients with stroke. However, there is no standardized procedure for when and how to intervene with AOT.ObjectivesThus, we reviewed and analyzed previous studies to provide a guideline for the application of AOT in stroke rehabilitation.MethodWe searched PubMed, Cochrane Library, and EMBASE from inception to October 31 2022, using title and abstract search terms of “action observation” and “stroke” or “hemiplegia.” Of 4108 potential articles, 29 articles (sample size = 429 in AOT groups; sample size = 423 in control groups) that met inclusion criteria were included in final analyses.ResultsThe results suggested starting adjuvant AOT > 23 days after stroke onset and conducting 30–40 min/session, 3–5 times/week for at least 4 weeks.ConclusionBased on our results, many factors will impact the effect of AOT on stroke rehabilitation, when to apply (timing) and how to apply (frequency, single, and total duration) should be fully considered when applying AOT as adjuvant therapy in stroke rehabilitation.
Depression diagnosis based on electroencephalography power ratios
Authors: Chang Jinwon , Choi Yuha 
Published: July 2023

AbstractBackgroundDepression is a common mental disorder that impacts millions of people across the world. However, its diagnosis is difficult due to the dependence on subjective testing. Although quantitative electroencephalography (EEG) has been investigated as a promising diagnostic tool for depression, the associated results have proven contradictory. The current study determines whether the alpha/beta (ABR), alpha/theta (ATR), and theta/beta (TBR) ratios can serve as biological markers of depression.MethodsWe used open‐access EEG data from OpenNeuro to investigate power ratios in the resting state of 46 patients with depression and 75 healthy controls. Spectral data were extracted by fast Fourier transform at the theta band (4–8 Hz), alpha band (8–13 Hz), and beta band (13–32 Hz). Neural network, logistic regression, and receiver operating characteristic (ROC) curves were used to assess the diagnostic accuracies of each suggested index. Additionally, the cutoff point, sensitivity, specificity, positive predictive value, and negative predictive value at the maximized Youden index were compared for each variable.ResultsDecreased anterior frontal, frontal, central, parietal, occipital, and temporal ABR and decreased central and parietal TBR were observed in the depression group. The area under the curve of the ROC curves further revealed that these ratios could all effectively differentiate depression. In particular, the central, frontal, and parietal ABR exhibited high discrimination scores. Multiple logistic regression analysis demonstrated that the Beck Depression Inventory and Spielberger Trait Anxiety Inventory scores, as well as the probability of depression, increased with a decrease in the central ABR. Moreover, neural network analysis revealed that the global ABR was the most effective index for diagnosing depression among the three global EEG power ratios.ConclusionsThe central, frontal, and parietal ABR represent potential biomarkers to differentiate patients with depression from healthy controls.
Clinical characterization of epilepsy in children with chromosomal aberration 47, XXY
Authors: Chen Congjie , Luo Yuanyuan , Hou Xueqing , Li Tingsong 
Published: July 2023

AbstractObjectiveThe phenotype of the chromosomal aberration 47, XXY exhibits considerable heterogenicity. In addition, epilepsy is extremely uncommon in individuals with this chromosomal disorder. As a result, the clinical characteristics of epilepsy in these patients remain poorly understood.MethodsClinical data and the evolution of epilepsy in a boy diagnosed with chromosomal aberration 47, XXY were collected and analyzed. Furthermore, a systematic literature review was conducted to examine the relationship between chromosomal aberration 47, XXY and epilepsy in children.ResultsWe identified a novel phenotype associated with the chromosomal anomaly 47, XXY in a 2‐year‐2‐month‐old boy who presented with self‐limited epilepsy with autonomic seizures at onset, followed by developmental and/or epileptic encephalopathy with spike‐wave activation in sleep (D/EE‐SWAS), which was responsive to corticosteroid treatment. Including the present case, we analyzed 21 cases of children diagnosed with epilepsy due to the presence of the 47, XXY chromosomal anomaly. The most common types of epilepsy were focal combined generalized epilepsy (n = 9), epileptic spasms (n = 6), and generalized epilepsy (n = 4). There were six cases of infantile epileptic spasm syndrome (IESS) (n = 5) and developmental and epileptic encephalopathy (n = 1), one case of Lennox–Gastaut syndrome, and one case of D/EE‐SWAS. Apart from corticosteroids in IESS, 15 antiseizure medications (ASMs) were prescribed to eight children in this cohort, with valproate (n = 5) being the most frequently used.ConclusionsThe epilepsy types and syndromes associated with the chromosomal anomaly 47, XXY demonstrated considerable heterogeneity. Among the observed phenotypes, IESS and focal epilepsy, which displayed partial responsiveness to multiple ASMs, were the most prevalent.
An HGF‐dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis
Authors: Li Yuting , Zheng Hanhao , Luo Yuming , Lin Yan , An Mingjie , Kong Yao , Zhao Yue , Yin Yina , Ai Le , Huang Jian , Chen Changhao 
Published: July 2023

AbstractBackgroundCancer‐associated fibroblasts (CAFs) play a vital role in facilitating tumor progression through extensive reciprocal interplay with cancer cells. Tumor‐derived extracellular vesicles (EVs) are the critical mediators involved in the crosstalk between cancer cells and stromal cells, contributing to the metastasis of cancers. Yet, the biological mechanisms of tumor‐derived EVs in triggering CAFs phenotype to stimulate the lymph node (LN) metastasis of bladder cancer (BCa) are largely unknown. Here, we aimed to explore the effects and molecular mechanisms of tumor‐derived EV‐mediated CAFs phenotype in regulating BCa LN metastasis.MethodsThe high‐throughput sequencing was utilized to identify the crucial long non‐coding RNA (lncRNA) associated with CAF enrichment in BCa. The functional role of the transition of fibroblasts to CAFs induced by LINC00665‐mediated EVs was investigated through the in vitro and in vivo assays. Chromatin isolation by RNA purification assays, fluorescence resonance energy transfer assays, cytokine profiling and patient‐derived xenograft (PDX) model were performed to explore the underlying mechanism of LINC00665 in the LN metastasis of BCa.ResultsWe found that CAFs are widely enriched in the tumor microenvironment of BCa, which correlated with BCa lymphangiogenesis and LN metastasis. We then identified a CAF‐associated long non‐coding RNA, LINC00665, which acted as a crucial mediator of CAF infiltration in BCa. Clinically, LINC00665 was associated with LN metastasis and poor prognosis in patients with BCa. Mechanistically, LINC00665 transcriptionally upregulated RAB27B expression and induced H3K4me3 modification on the promoter of RAB27B through the recruitment of hnRNPL. Moreover, RAB27B‐induced EVs secretion endowed fibroblasts with the CAF phenotype, which reciprocally induced LINC00665 overexpression to form a RAB27B‐HGF‐c‐Myc positive feedback loop, enhancing the lymphangiogenesis and LN metastasis of BCa. Importantly, we demonstrated that blocking EV‐transmitted LINC00665 or HGF broke this loop and impaired BCa lymphangiogenesis in a PDX model.ConclusionOur study uncovers a precise mechanism that LINC00665 sustains BCa LN metastasis by inducing a RAB27B‐HGF‐c‐Myc positive feedback loop between BCa cells and fibroblasts, suggesting that LINC00665 could be a promising therapeutic target for patients with LN metastatic BCa.
Shades of awe: The role of awe in consumers' pro‐environmental behavior
Authors: Kaplan Begum , Miller Elizabeth G. , Iyer Easwar S. 
Published: July 2023

AbstractClimate change is a critical issue right now. Despite substantial work in academia examining this issue, more solutions are needed to encourage consumers to engage in more pro‐environmental behavior. In the current research, we explore the ability of awe, a unique and powerful self‐transcendent emotion, to motivate pro‐environmental behavior and green consumption. Using different methods to induce awe and assess the effect of awe on consumers' pro‐environmental behavior, we conducted three experimental studies. Across our studies, our results show that when consumers feel awe, they are more likely to engage in pro‐environmental behavior and consumption. Further, we distinguish among three kinds of awe (awe of nature, awe of God, and awe from man‐made wonders) and show that awe arising from nature and from God increases pro‐environmental behavior more than awe from man‐made wonders. In addition, a series of mediation analyses show that the effects distinguishing different sources of awe are best accounted for by different mediators rather than one common mediator; specifically these relationships are mediated by consumers' feelings of small self (i.e., diminished self‐concept) and their level of spirituality, respectively. Implications for how marketers and practitioners can best utilize the power of awe for encouraging pro‐environmental behavior are discussed.
Acute decompensated heart failure after transcatheter aortic valve implantation: A case report
Authors: Kim Hong Nyun , Yang Dong Heon , Park Bo Eun 
Published: July 2023

Key Clinical MessageTranscatheter aortic valve implantation (TVAI) is a widely used treatment modality for severe aortic stenosis. The complication rates of the procedure have gradually decreased over time, owing to the improvements in procedural skills and development of TVAI devices. However, several rare but serious complications can still occur after TAVI. We recently encountered acute decompensated heart failure as a rare and fatal complication of TAVI and would like to share our experience.
Surgical reconstruction for spheno‐orbital meningioma extending into the sphenoid sinus with hyperostosis
Authors: Maki Toshihito , Ito Eiji , Saito Kiyoshi , Saito Ryuta 
Published: July 2023

Key Clinical MessageSpheno‐orbital meningiomas (SOMs) are complex tumors that grow and extend into nearby structures. SOM tumor growth is often associated with hyperostosis caused by tumor cell infiltration and bone alteration. We describe the case of a 64‐year‐old man with SOM that extended into the sphenoid sinus without a direct connection between the intracranial and extracranial lesions. This report emphasizes the importance of identifying the growth patterns of SOMs and assessing the paranasal sinuses adjacent to the hyperostotic orbit walls from preoperative images.
Oscillating neural circuits: Phase, amplitude, and the complex normal distribution
Authors: Urban Konrad N. , Bong Heejong , Orellana Josue , Kass Robert E. 
Published: July 2023

AbstractMultiple oscillating time series are typically analyzed in the frequency domain, where coherence is usually said to represent the magnitude of the correlation between two signals at a particular frequency. The correlation being referenced is complex‐valued and is similar to the real‐valued Pearson correlation in some ways but not others. We discuss the dependence among oscillating series in the context of the multivariate complex normal distribution, which plays a role for vectors of complex random variables analogous to the usual multivariate normal distribution for vectors of real‐valued random variables. We emphasize special cases that are valuable for the neural data we are interested in and provide new variations on existing results. We then introduce a complex latent variable model for narrowly band‐pass‐filtered signals at some frequency, and show that the resulting maximum likelihood estimate produces a latent coherence that is equivalent to the magnitude of the complex canonical correlation at the given frequency. We also derive an equivalence between partial coherence and the magnitude of complex partial correlation, at a given frequency. Our theoretical framework leads to interpretable results for an interesting multivariate dataset from the Allen Institute for Brain Science.
Feasibility and preliminary effect of a couple‐based posttraumatic growth intervention for colorectal cancer couples: A randomized controlled pilot study
Authors: Wang Zhiming , Chen Xuan , Zhou Junrui , Lin Chunyan , Luo Huamin , Li Qiuping 
Published: July 2023

AbstractBackgroundColorectal cancer (CRC) causes severe physical and psychological impacts on the patients as well as their spousal caregivers. To facilitate the psychological adaptation of the CRC suffered couples, a couple‐based posttraumatic growth (PTG) intervention was developed based on the PTG affective‐cognitive processing model. The feasibility, acceptability and preliminary effect of this intervention were tested.MethodsA pre–post randomized controlled pilot trail was conducted for Chinese couples coping with CRC. Participants in the intervention group were provided five weekly sessions consecutively, while those in the control group were treated with usual care during the testing period. Outcomes were described as positive changes (PTG, benefit finding [BF]), marital satisfaction, quality of life and anxiety and depression. Qualitative method was also used to evaluate the programme participating sense of the couples.ResultsThe rate of programme recruitment and programme retention amounts to 78.6% and 87.5%, respectively. The participants have reported overall satisfaction for the programme attendance and have suggested detailed diet guidance. Significant effects were revealed in the outcomes for the CRC couples, including PTG, marital satisfaction, BF, physical and mental health and anxiety and depression.ConclusionThe study confirmed the feasibility and preliminary positive effect of the couple‐based PTG intervention for the CRC couples. However, in order to extend it in more general applications, large‐scale researches are warranted.Practical implicationThe couple‐based intervention is effective for couples coping with CRC. Clinicians should take the components of the intervention into consideration in their practice work for the CRC couples.
What makes an obsession? A systematic‐review and meta‐analysis on the specific characteristics of intrusive cognitions in OCD in comparison with other clinical and non‐clinical populations
Authors: Audet Jean‐Sébastien , Bourguignon Lysandre , Aardema Frederick 
Published: July 2023

AbstractThe Diagnostic and Statistical Manual 5th ed. defines obsessions in obsessive–compulsive disorder (OCD) as frequent, persistent, intrusive, unwanted thoughts that provoke anxiety and distress and lead to attempts to neutralize them with either thoughts or actions. However, no systematic review has yet evaluated characteristics that are specific to obsessions occurring in OCD. The aim of the current systematic review and meta‐analysis was to investigate the specific features of obsessions occurring in OCD by comparing them to both obsessionally and non‐obsessionally‐themed intrusions in non‐clinical and other clinical populations. Based on a registered protocol, 832 records were found, of which 15 were included in the systematic review and meta‐analysis, with a total of 1891 participants. Obsessionally‐themed intrusions that occur among those with OCD caused more distress, guilt, negative emotion and interference as compared to similarly‐themed intrusions that occur within the general population. The distinction between obsessionally‐themed intrusions among those with OCD as compared to those occurring in anxiety and depressive disorder primarily revolves around a higher level of persistence, pervasiveness and distress associated with their occurrence. Further, unacceptability, uncontrollability, ego‐dystonicity, alienness, guilt, the form of the intrusion, association with the self and lack of any basis in reality also differentiates between obsessions and intrusions occurring in other disorders. Obsessions share many characteristics with thoughts occurring in other disorders and can be distinguished using a combination of characteristics specific to individual disorders.
Spring wheat canopy effects on light dynamics and yield of intercropped fine fescues
Authors: Breuillin‐Sessoms Florence , Petrella Dominic P. , Ehlke Nancy J. , Vellekson Donn , Watkins Eric 
Published: July 2023

AbstractTurfgrass stakeholder surveys have indicated fine fescue (Festuca spp.) seed will become in higher demand, but fine fescue seed production in the United States, especially in Oregon, has not increased. Northern Minnesota is conducive for cool‐season turfgrass seed production and has existing infrastructure to produce turfgrass seed. There is an exciting opportunity for Northern Minnesotan farmers to increase revenue by producing fine fescue seed; however, fine fescues require a growing season for establishment prior to seed production, and an economic crop during the first growing season is needed. Most fine fescues are considered shade tolerant and should establish under spring wheat (Triticum aestivum L.), which is the current cropping system used for perennial ryegrass (Lolium perenne L.) seed production in Minnesota. Experiments were established in Roseau (2018 and 2019) and St. Paul (2018) in which several cultivars of Chewings, hard and strong creeping red fescue were interseeded with spring wheat. Our objectives were to examine stand and seed production of these three fine fescue taxa in comparison with perennial ryegrass. All three taxa were negatively affected by wheat, possibly from excessive shade from the wheat canopy. The fine fescue culm index (number of culms relative to whole‐plant biomass) grown in wheat was lower, indicating that vernalization was negatively impacted, resulting in seed yield reduction. Our results demonstrate that the currently used perennial ryegrass–spring wheat cropping system is not optimized for fine fescue seed production, especially hard fescue, and more research is needed to improve this cropping system in Northern Minnesota.
Fusarium wilt–common bean pathosystem: Pathogen variability and genetic control
Authors: Benchimol‐Reis Luciana L. , Bueno César J. , Carbonell Sérgio A. M. , Chiorato Alisson F. 
Published: July 2023

AbstractSustainable management of plant diseases has been a challenge in the effort to feed a human population that has increased substantially. One of the main diseases that affect common bean and dry bean is Fusarium wilt, caused by the fungus Fusarium oxysporum f. sp. phaseoli (Fop), which can cause losses of up to 100% in crop production. The Fop infection process starts in the roots, followed by colonization and obstruction of xylem vessels, leading to leaf wilting, vascular discoloration, chlorosis, dwarfism, and premature plant death. Fop show high genetic variability, and seven different physiological races have been reported in different regions of the world. There is also a study in which the formae specialis designation has been replaced by Fusarium species. Different studies in common bean have shown that physical, biological, and chemical changes are involved in the Fop resistance mechanism and in the Fusarium and common bean pathosystem. Many studies have been conducted to detect candidate genes and pathways associated with resistance to Fop. This work offers useful information for advancing common bean resistance breeding.
The vitamin B5/coenzyme A axis: A target for immunomodulation?
Authors: Miallot Richard , Millet Virginie , Galland Franck , Naquet Philippe 
Published: July 2023

AbstractCoenzyme A (CoA) serves as a vital cofactor in numerous enzymatic reactions involved in energy production, lipid metabolism, and synthesis of essential molecules. Dysregulation of CoA‐dependent metabolic pathways can contribute to chronic diseases, such as inflammatory diseases, obesity, diabetes, cancer, and cardiovascular disorders. Additionally, CoA influences immune cell activation by modulating the metabolism of these cells, thereby affecting their proliferation, differentiation, and effector functions. Targeting CoA metabolism presents a promising avenue for therapeutic intervention, as it can potentially restore metabolic balance, mitigate chronic inflammation, and enhance immune cell function. This might ultimately improve the management and outcomes for these diseases. This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin B5/pantothenate in vivo and modulating the development of Th17‐mediated inflammation, CD8‐dependent anti‐tumor immunity but also tissue repair processes in chronic inflammatory or degenerative diseases.
Toward development of dual optical and electrical cell‐based biosensor: An investigation on electrode geometry and transparent conductive material function
Authors: Arman Seyedyousef , Gonçales Vinicius R. , Yang Ying , Tilley Richard D. , Gaus Katharina , Gooding J. Justin 
Published: July 2023

AbstractHerein is explored a dual optical and electrical cell based biosensor that can provide insights into cellular events. The fabrication steps along with the electrical characterization of the microelectrodes is described. Initial experiments show that the ability of indium tin oxide (ITO) to detect biological cells at the electrode‐cell layer interface mainly depends on the size of sensing area. Following this, the impact of conductivity was also explored to assess the real time impedance signal during the adhesion of a non‐confluent layer of the cells on different substrates. Electrodes with a higher conductivity than ITO gave much higher senstivity of impedance changes which allowed the dynamics of subtle cellular morphology changes to be monitored at densities far lower than a confluent layer of cells. Finally, the capability of ITO and gold microelectrode as a functional readout for G protein couple receptor activation were determined. These set of analyses highlighted the challenges and opportunities of ITO substrate as a dual cell‐based assay for quantitative analysis of subtle changes in cell morphology.