bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological insulin resistance and its impact on self‐management in type II diabetes mellitus patients treated with insulin therapy
Authors: Fu Chiung‐Hui , Lee Li‐Yun , Huang Li‐Chuan , Tsay Shiow‐Luan , Chen Shu‐Ching 
Published: August 2023

AbstractAimsPsychological insulin resistance is a common barrier to initiation and persistence with insulin therapy that affects approximately 42.7% of people living with type II diabetes mellitus, which may negatively impact self‐management. This study aimed to assess patients' levels of psychological insulin resistance and to identify factors associated with self‐management in patients with type II diabetes mellitus treated with insulin therapy.MethodsWe adopted a cross‐sectional design. Subjects from the metabolism and endocrinology outpatient departments of a regional teaching hospital in central Taiwan were recruited by consecutive sampling. Patients were assessed for psychological insulin resistance and self‐management using the barriers to insulin treatment questionnaire and the partners in health scale.ResultsA total of 222 patients with type II diabetes mellitus were recruited. Patients had an average psychological insulin resistance score of 3.14 (maximum of 8). Positive self‐management was associated with insulin therapy injection by patient, fewer expectations regarding positive insulin‐related outcomes, no diabetes‐related complications, less fear of injection and self‐testing, no hypoglycaemia within the previous year, and younger age.ConclusionInsulin therapy injection by patient and no diabetes‐related complications were the most common factors associated with overall self‐management and with each domain of self‐management in patients with type II diabetes mellitus treated with insulin therapy. Insulin therapy education should be offered to improve patients' beliefs about insulin therapy and enhance patients' ability to perform self‐management.
Extracellular vesicles‐transmitted long non‐coding RNA MTUS2‐5 promotes proliferation and vascularization of human vascular endothelial cells in patients with Budd–Chiari syndrome
Authors: Zhang Longfei , Feng Benchi , Zhou Zhuxin , Huang Hanlin , Yu Chaowen , Wang Xiaogao , Xu Chao , Gao Yong , Chen Shiyuan 
Published: August 2023

AbstractThe high rates of misdiagnosis and untreated mortality with regard to Budd–Chiari syndrome (BCS) indicated the need to screen effective biomarkers. The aim of this study was to explore the function of extracellular vesicles (EVs) in patients with BCS as well as associated mechanisms. First, differentially expressed long non‐coding RNAs (lncRNAs) from EVs separated from serum between BCS and healthy controls were screened using microarray analysis. Second, the proliferation, migration and tube formation of human vascular endothelial cells (HUVECs) were detected after EVs treatment, along with vascular endothelial growth factor (VEGF) levels and inflammatory factors from the cell supernatant. Last, the overexpressed lncRNA was transfected into the cells to further explore the mechanisms involved. Extracellular vesicles of BCS patients have significantly higher levels of lncRNA MTUS2‐5 than healthy controls. Apparently, treatment with EVs from BCS or the ones transfected with plasmids that overexpress lncRNA MTUS2‐5 enhances proliferation, migration and angiogenesis capacity. The results were considerably better than those obtained from treatment with EVs from healthy controls or transfection with the normal control plasmid, which also elevated the level of VEGF and inflammatory factors. Furthermore, FOS and PTGS2 were potentially regulated by the lncRNA MTUS2‐5 transmitted by EVs. The lncRNA MTUS2‐5 in EVs plays an important role in angiogenesis in the Budd–Chiari syndrome.
Effects of different hormones as dietary supplements on biological characteristics of Coccinella septempunctata L.
Authors: Cheng Ying , Zhou Yuhang , Ran Haiyan , Li Fengliang 
Published: August 2023

AbstractWhen Coccinella septempunctata L. was fed on an artificial diet, development was prolonged and survival and reproduction were decreased, thus negatively affecting population growth. Juvenile hormone and moulting hormones are important factors in insect reproduction and development. This study aims to screen out the optimal hormones that can solve the problems such as slow population growth of the C. septempunctata during mass rearing, thus improving their effectiveness as a biological control agent. The effects of juvenile hormone analogues and moulting hormones on C. septempunctata larval growth and adult reproduction were investigated by supplementing an artificial diet with different doses of methoprene, kinoprene, juvenile hormone Ш, fenoxycarb and 20‐hydroxyecdysone. Multiple parameters were measured for C. septempunctata including development, survival, pupation, emergence, pre‐oviposition, fecundity and hatching rates. The addition of juvenile hormone analogues to the diet significantly lengthened larval development times and reduced pupation and emergence. Conversely, juvenile hormone analogues significantly shortened pre‐oviposition period, reduced survival and increased fecundity. The shortest pre‐oviposition period was 9.6 days, and the highest oviposition number was 578 eggs in response to 5 μL kinoprene. The highest hatching rate was 66% in 1.7 mg 20‐hydroxyecdysone treatment. The results of this study provide a theoretical basis for hormone selection and dosage in C. septempunctata artificial diets, thus enhancing the survival, pupation and emergence of larvae and improving the fecundity and hatching rate of ladybird adults.
Northerly range expansion and first confirmed records of the smalltooth sand tiger shark, Odontaspis ferox, in the United Kingdom and Ireland
Authors: Curnick David J. , Deaville Rob , Bortoluzzi Jenny R. , Cameron Luke , Carlsson Jeanette E. L. , Carlsson Jens , Dolton Haley R. , Gordon Cat A. , Hosegood Phil , Nilsson Alicia , Perkins Matthew W. , Purves Kevin J. , Spiro Simon , Vecchiato Marco , Williams Rosie S. , Payne Nicholas L. 
Published: August 2023

AbstractThree Odontaspis ferox (confirmed by mtDNA barcoding) were found in the English Channel and Celtic Sea in 2023 at Lepe, UK (50.7846, −1.3508), Kilmore Quay, Ireland (52.1714, −6.5937), and Lyme Bay, UK (50.6448, −2.9302). These are the first records of O. ferox in either country, and extend the species' range by over three degrees of latitude, to >52° N. They were ~275 (female), 433 (female), and 293 cm (male) total length, respectively. These continue a series of new records, possibly indicative of a climate change−induced shift in the species' range.
Bronchial tree of the human embryo: Examination based on a mammalian model
Authors: Fujii Sena , Muranaka Taiga , Matsubayashi Jun , Yamada Shigehito , Yoneyama Akio , Takakuwa Tetsuya 
Published: August 2023

AbstractThe symmetry of the right and left bronchi, proposed in a previous comparative anatomical study as the basic model of the mammalian bronchial tree, was examined to determine if it applied to the embryonic human bronchial tree. Imaging data of 41 human embryo specimens at Carnegie stages (CS) 16–23 (equivalent to 6–8 weeks after fertilization) belonging to the Kyoto collection were obtained using phase‐contrast X‐ray computed tomography. Three‐dimensional bronchial trees were then reconstructed from these images. Bronchi branching from both main bronchi were labeled as dorsal, ventral, medial, or lateral systems based on the branching position with numbering starting cranially. The length from the tracheal bifurcation to the branching point of the labeled bronchus was measured, and the right‐to‐left ratio of the same labeled bronchus in both lungs was calculated. In both lungs, the human embryonic bronchial tree showed symmetry with an alternating pattern of dorsal and lateral systems up to segmental bronchus B9 as the basic shape, with a more peripheral variation. This pattern is similar to that described in adult human lungs. Bronchial length increased with the CS in all labeled bronchi, whereas the right‐to‐left ratio was constant at approximately 1.0. The data demonstrated that the prototype of the human adult bronchial branching structure is formed and maintained in the embryonic stage. The morphology and branching position of all lobar bronchi and B6, B8, B9, and the subsegmental bronchus of B10 may be genetically determined. On the other hand, no common structures between individual embryos were found in the peripheral branches after the subsegmental bronchus of B10, suggesting that branch formation in this region is influenced more by environmental factors than by genetic factors.
Implementation strategies to improve posttraumatic stress disorder care in rural veterans
Authors: Bernardy Nancy C. , Cuccurullo Lisa‐Ann J. , Montano Macgregor , Bowen Michelle , Breen Kristen , Matteo Rebecca , Cole Bernard 
Published: August 2023

AbstractPurposePrior research has noted treatment inequalities in the care of rural veterans with posttraumatic stress disorder (PTSD). This project sought to increase the delivery, or reach, of recommended PTSD treatments in 2 rural health care systems of the Department of Veterans Affairs (VA) using implementation facilitation.MethodsThe quality improvement project involved 6 months of facilitation to 2 low‐reach PTSD clinics within 2 VA health care systems. The clinics were matched to a control clinic at another regional system similar in reach, rurality, and patient volume. We compared the delivery of evidence‐based psychotherapies (EBPs) for PTSD at 3 timepoints: baseline, 6 months, and 1 year using difference‐in‐difference effect estimation. Facilitators and barriers of EBP reach were identified through interviews with clinic staff and informed specific implementation plans. We also measured reductions in benzodiazepine prescriptions and polypharmacy to determine the impact of an academic detailing intervention aimed at improving PTSD prescribing practices at the 2 sites.FindingsEBP reach at 6 months more than doubled in the 2 PTSD clinics that received facilitation, while our control clinic experienced a decrease in EBP reach (DID = 24.6; SE = 6.71%). Both intervention clinics identified similar administrative barriers to the delivery of EBPs, offering useful information for improvement at other rural clinics. The use of academic detailing as part of our facilitation intervention further appears to have positively impacted care.ConclusionsIn this preliminary work, facilitation is a promising strategy for increasing the delivery of PTSD EBPs to veterans seen in under‐resourced rural VA clinics.
Teaching Chaucer in Tunisia: An interdisciplinary approach
Authors: Ayed Wajih 
Published: August 2023

AbstractPedagogies of the premodern in anglophone contexts face many obstacles, like cultural differences, linguistic remoteness, and stereotypical representations. In EFL learning and teaching settings, student motivation, cultural adequation, and historical imagination are also needed. In Tunisia, this was further complicated after the Jasmine Revolution when newly radicalised students of English resented aspects of premodern literature which they considered inaccurate, uninteresting, or inappropriate. In this paper, the author presents a learning and teaching model developed to help post‐revolutionary Tunisian learners with diverse backgrounds and orientations better understand and appreciate the works of Geoffrey Chaucer. Combining elements of cognitive studies, comparative literature, and digital codicology, this bricolage was used in graduate seminars at the University of Sousse to study digitised manuscripts and texts in Arabic, Latin, and (Middle) English. Informed by active pedagogy and enhanced by audio‐visual aids, activities based on this model effectively addressed challenges, helped achieve learning outcomes, and made Tunisians more at home with Chaucer.
The correlates of flow in the L2 classroom: Linking basic L2 task features to learner flow experiences
Authors: Zuniga Michael 
Published: August 2023

AbstractFlow is an intrinsic motivational state associated with full task engagement, positive affect, and enhanced performance. While research has examined how different language tasks interact with flow experiences, no study has examined learner flow experiences in a wide range of tasks using an experience sampling method to determine how universal basic task features (e.g., modality, participant structure, information distribution, and targeted skills) interact with flow. The present study aims to respond to this gap in the research. Participants were 13 teachers and 327 students from 18 intact French L2 classes in a Canadian postsecondary school. Teachers selected and implemented an average of six tasks from their personal repertoires at random moments throughout the semester. Immediately following each task, learners anonymously completed a flow experience questionnaire (N = 1408;α = 0.91), and teachers a task description questionnaire containing 17 basic task features (N = 81). Statistical analyses show that 10 of the 17 variables significantly interacted with learners’ flow experiences. The results not only validate a frequently used flow measurement and establish norms for future research but also outline a framework language teachers can use to evaluate and modify practices to improve learners’ subjective classroom experience.
Use of word lists in a high‐stakes, low‐exposure context: Topic‐driven or frequency‐informed
Authors: Marsden Emma , Dudley Amber , Hawkes Rachel 
Published: August 2023

AbstractThe awarding organizations that create and administer high‐stakes assessments for beginner‐to‐low‐intermediate 16‐year‐old learners of French, German, and Spanish in England provide optional topic‐driven word lists as guides for teachers and textbook writers. Given that these lists are developed by the awarding organizations, they exert a powerful washback effect on teaching and learning. However, we do not know how much of these lists have actually been used in exams. We therefore analyzed the extent to which these lists have been used when developing the General Certificate of Secondary Education listening and reading exams, a corpus totaling 116,647 words. One key finding showed that approximately half of the awarding organizations’ lists had never been used in any of the exams to date. Given recent changes to curriculum policy, we also investigated how word list type—frequency‐informed versus the awarding organizations’ topic‐driven lists—affected lexical coverage of the exams. Overall, our findings suggested that using the topic‐driven lists was likely to be a suboptimal use of lesson time, as they did not provide learners with enough words to understand any given text with ease. Frequency‐informed word lists, however, seemed to better prepare learners for the exams.
Translingual caring and translingual aggression: (Re)centering criticality in the research and practice of translanguaging pedagogy
Authors: Qin Kongji , Llosa Lorena 
Published: August 2023

AbstractOver the last decade, translanguaging pedagogy has gained much traction in language education and has been taken up in a wide range of educational settings. Studies on translanguaging pedagogy, however, have largely focused on its affordances; research on its challenges remains limited. This classroom discourse study examines both the affordances and challenges of translanguaging pedagogy by analyzing the functions of translanguaging practices in one US superdiverse, multilingual secondary science classroom. Taking up the lens of criticality and superdiversity, we view classrooms as power‐laden spaces and translanguaging as a social practice shaped by and shaping social norms and ideologies. Through discourse analyses of classroom interactions and interview data, we identified seven functions of classroom translanguaging practices. Our analysis shows that translanguaging offered students translingual support for accessing meaning and instruction and allowed the teacher to build relationships with students through translingual caring and translingual critical love. Students also engaged in translanguaging for translingual bonding and creating translingual safe houses. However, translanguaging was also used for translingual exclusion and translingual aggression. Our analysis sheds light on the complexity of translanguaging pedagogy. We call for (re)centering criticality in the research and practice of translanguaging pedagogy and developing students’ critical language awareness in translanguaging classrooms.
The Austrian landscape of diagnostic capacity and access to treatment for invasive fungal infections
Authors: Salmanton‐García Jon , Hoenigl Martin , Salzer Helmut J. F. , Lackner Michaela , Prattes Juergen , Dichtl Karl , Winkler‐Zamani Markus , Krause Robert , Stemler Jannik , Lass‐Flörl Cornelia , Cornely Oliver A. , Willinger Birgit 
Published: August 2023

AbstractIntroductionImmunosuppression after chemotherapy, stem cell transplantation or solid organ transplantation are the main risk factors for invasive fungal infections in Austria. Here, we aim to describe the status of laboratory mycology and the access to antifungal treatment in Austria.MethodsBetween October and November 2021, hospitals were contacted to participate in our online survey: www.clinicalsurveys.net/uc/IFI_management_capacity/. Centres were required to provide information on their institutional profile; self‐assessment of burden of invasive fungal infections; access to microscopy, culture, serology, antigen detection and molecular testing; and availability of antifungal agents and therapeutic drug monitoring.ResultsResponses were collected from university hospitals and laboratories in Graz, Innsbruck, Linz and Vienna. The four hospitals can provide tertiary care and were highly specialised, including management of patients with severe immunosuppression. All sites consider the incidence of invasive fungal infections to be moderate. Access to microscopy, culture, serology, antigen detection and molecular testing is provided regardless of laboratory. The maximum capacity to identify fungi varies from institution to institution. All currently marketed antifungal agents are available at the four sites.ConclusionAustria is currently well equipped to deal with the emerging threat of invasive fungal infections. However, hospitals may consider preparing for the potential endemicity of certain infections in the near future.
Evaluating the understandability and actionability of online educational videos on pre‐dialysis chronic kidney disease
Authors: Furukawa Emi , Okuhara Tsuyoshi , Okada Hiroko , Fujitomo Yumiko , Osa Mari , Hashiba Toyohiro , Kiuchi Takahiro 
Published: August 2023

AbstractAimIt remains undetermined whether online education videos for Japanese patients with chronic kidney disease (CKD) are easy to understand and allow adoption of behavioural changes. This study quantitatively assessed the understandability and applicability of online education videos for patients with CKD.MethodsIn September 2021, we identified 200 videos on YouTube using the Japanese translations of the keywords ‘kidney,’ ‘kidney disease,’ ‘CKD,’ and ‘chronic kidney disease.’ We used the Japanese version of the Patient Education Materials Assessment Tool to evaluate the understandability and usability of webpages on a scale of 0% to 100%. The cut‐off was set at 70%.ResultsA total of 54 videos were evaluated. The overall understandability and actionability of the materials were 57.6 (SD = 22.6) and 53.7 (SD = 33.4), respectively. Approximately 70% and 60% of the materials were considered insufficiently understandable and actionable, respectively. Most videos lacked a summary and had difficulty in using only everyday language. Most videos included at least one action for the audience to take. However, many failed to break down the action into sequential steps. They also lack visual aids to encourage the audience to take action.ConclusionOur results suggest that current information on pre‐dialysis chronic kidney disease was not presented in a manner that can be applied by laypeople.
A receptor‐like kinase SlFERL mediates immune responses of tomato to Botrytis cinerea by recognizing BcPG1 and fine‐tuning MAPK signaling
Authors: Ji Dongchao , Liu Wei , Cui Xiaomin , Liu Kui , Liu Yuhan , Huang Xinhua , Li Boqiang , Qin Guozheng , Chen Tong , Tian Shiping 
Published: August 2023

Summary

FERONIA (FER) is a receptor‐like kinase showing versatile functions during plant growth, development, and responses to environmental stimuli. However, its functions during the interaction between fruit and necrotrophic fungal pathogens are still unclear.

Combining reverse genetic approaches, physiological assays, co‐immunoprecipitation, protein phosphorylation identification, and site‐directed mutagenesis, we reported a tomato FER homolog SlFERL (Solanum lycopersicum FERONIA Like) involved in the immune responses to Botrytis cinerea invasion.

The results indicated that SlFERL extracellular domain recognized and interacted with the secreted virulence protein BcPG1 from B. cinerea, further revealed that SlFERL triggered downstream signaling by phosphorylating SlMAP3K18 at Thr45, Ser49, Ser76, and Ser135. Moreover, we verified that SlMAP2K2 and SlMAP2K4 synergistically contributed to immune response of tomato to B. cinerea, in which SlFERL‐SlMAP3K18 module substantially modulated protein level and/or kinase activity of SlMAP2K2/SlMAP2K4.

These findings reveal a new pattern‐triggered immune pathway, indicating that SlFERL participates in the immune responses to B. cinerea invasion via recognizing BcPG1 and fine‐tuning MAPK signaling.
Characterizing affiliative touch in humans and its role in advancing haptic design
Authors: Kryklywy James H. , Vyas Preeti , Maclean Karon E. , Todd Rebecca M. 
Published: August 2023

AbstractAn emerging view in cognitive neuroscience holds that the extraction of emotional relevance from sensory experience extends beyond the centralized appraisal of sensation in associative brain regions, including frontal and medial‐temporal cortices. This view holds that sensory information can be emotionally valenced from the point of contact with the world. This view is supported by recent research characterizing the human affiliative touch system, which carries signals of soft, stroking touch to the central nervous system and is mediated by dedicated C‐tactile afferent receptors. This basic scientific research on the human affiliative touch system is informed by, and informs, technology design for communicating and regulating emotion through touch. Here, we review recent research on the basic biology and cognitive neuroscience of affiliative touch, its regulatory effects across the lifespan, and the factors that modulate it. We further review recent work on the design of haptic technologies, devices that stimulate the affiliative touch system, such as wearable technologies that apply the sensation of soft stroking or other skin‐to‐skin contact, to promote physiological regulation. We then point to future directions in interdisciplinary research aimed at both furthering scientific understanding and application of haptic technology for health and wellbeing.