bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy associated breast cancer: Correlation between Parity and Prognostic Factors
Authors: CHEN Yaling , CHEN Jiajian , QI Xiuzhu , LIU Yajing , Qian Yu , CHANG Cai , LI Na , GAO Yi 
Published: August 2023

Abstract
Background and Purpose
Pregnancy associated breast cancer (PABC) has attracted more attention recently. Previous studies have focused on comparison between the prognosis of PABC and non-PABC. This study aimed to investigate the correlation between parity and prognostic factors of PABC.
Methods
In this retrospective study, patients with PABC who underwent surgery at Fudan University Shanghai Cancer Center between 2017 and 2021 were analyzed. Data concerning tumor characteristics, reproductive history and survival outcome were recorded.
Results
In total, the median age of 203 patients enrolled was 34 years (range, 22 years to 46 years). Compared with primiparous group, multiparous group had higher rate of clinical stage III ~ IV [33.9% (41/121) vs 18.3% (15/82), P < 0.001], higher rate of IDC of histological grade III [72.9% (62/85) vs 62.5% (40/64), P = 0.002], higher rate of lymphatic metastasis [57.0% (69/121) vs 41.5% (34/82), P = 0.030]. Among the patients who underwent neoadjuvant chemotherapy, multiparous group had higher rate of pathological complete response than primiparous group [57.8% (26/45) vs 34.4% (11/32), P = 0.043]. The 2-year disease-free survival rate of primiparous and multiparous group were 82.0% and 74.2% respectively (P = 0.212).
Conclusions
Multiparity was correlated with worse prognostic factors in PABC patients, but no evidence suggesting correlation with worse survival yet.
WITHDRAWN: The Generalized Weibull Poisson G Family of Continuous Probability Distributions with Copulas, Mathematical Properties and Applications to Real Data Sets
Authors: Hashem Atef F. , Abdelkawy M. A. , Muse Abdisalam Hassan , Yousof Haitham M. 
Published: August 2023

Abstract
This scientific report aims to provide a comprehensive understanding of new compound G family of probability distributions with copulas, shedding light on their mathematical properties and demonstrating their applicability in various real data settings. The insights from this study can benefit researchers, statisticians, and practitioners in their efforts to model complex dependencies and make informed decisions based on multivariate data analysis. The versatility of compound families of continuous probability distributions makes them useful for modelling a variety of events. They can be used to simulate the distribution of a system's time to failure, the amount of money lost in a financial transaction, or the number of accidents in a particular year, for instance. One of the main advantages of using compound families of continuous probability distributions is that they are flexible. This means that they can be used to model a wide range of phenomena, even those that are not well-described by other distributions. Additionally, compound families of continuous probability distributions are often easy to understand and use. Another advantage of using compound families of continuous probability distributions is that they can be used to model the dependence between two or more random variables. In this work, a novel G family called the generalized Weibull Poisson G family is derived and analyzed. The new compound G family of distributions is derived based on the zero-truncated-Poisson G and the generalized Weibull G families. Its statistical characteristics are mathematically studied. The Clayton copula, Archimedean-Ali-Mikhail-Haq copula, Renyi's entropy copula, copula of Farlie, Gumbel and Morgenstern and its modified version which contains four minor types are used to construct some new bivariate type G families. The Lomax model with one parameter receives special attention. The relevance of the new family is demonstrated through two examples from everyday life.
The role of preoperative hematology markers in the classification and molecular subtypes of newly diagnosed high-grade gliomas
Authors: Jia Xin , Han Xian , Xiong Mingsong , Zhao Sheng , Liu Jun , Xu Dengbang , Luo Jiben , Chen Xiaozhong , Luo Heng 
Published: August 2023

Abstract

Background: The purpose of our study was to explore the diagnostic value of single and combined hematological makers for the classification and isocitrate dehydrogenase (IDH)-1/2 mutation molecular subtypes of high-grade gliomas (HGGs).
Methods: A total of 354 newly diagnosed HGG patients were included in this study. First, we compared the levels of hematology indicators in the classification and molecular subtypes of HGGs. Next, the correlation between the levels of hematology indicators and basic clinical features was analyzed. Finally, the diagnostic value of the single and combined hematology indicators for identifying the classification and molecular subtypes of HGGs was determined.
Results: The level of fibrinogen (FIB) was higher in Grade IV (G4) gliomas and G4 IDH wild type (G4 IDH-wt). Nutrition-related indicators such as serum albumin (ALB), albumin/globulin ratio (AGR), and prognostic nutrition index (PNI) were negatively correlated with age, whereas FIB was positively associated with age. Compared with women, men with G4 had a significantly higher AGR and lower serum globulin (GLOB). We found that the best single and combined indicators for distinguishing G4 and G4 IDH-wt from HGGs were FIB [0.595 (0.519-0.672) and 0.615 (0.546-0.684)] and age+FIB [0.712 (0.642-0.783) and 0.726 (0.662-0.791)], respectively.
Conclusions: Preoperative hematological indicators have high diagnostic value for distinguishing G4 and G4 IDH-wt from HGGs, especially FIB combined with age.
Determining the Relationship Between Smoking Behaviors and Menstrual Irregularity in Women
Authors: YAVUZ Nurgül ŞİMAL , Kucukkelepce Didem Simsek , Golbası Zehra 
Published: August 2023

Abstract

Purpose
Smoking rates are increasing among women. Considering that menstrual irregularities are also common, it is thought that there is a need for studies examining the relationship between menstrual irregularities and smoking in women of reproductive age. Therefore, this study was carried out to determine the relationship between women's smoking behaviors and menstrual irregularities.
Methods
Between November and December 2022, the study was done among women aged 15 to 49 in Turkey. The data were collected using the Personal Information Form and the Fagerstrom test for Nicotine Dependence. Data collection tools were converted online via Google Forms, and the link was shared with the participants via e-mail and the WhatsApp messenger application. This cross-sectional and relational study was conducted with a total of 630 women. Descriptive statistics an independent t-test, an ANOVA, and Post hoc analyses were used for the statistical analysis of the study. In statistical analyses, p < 0.05 was accepted as significant.
Results
The study showed that the mean total nicotine dependence of women was 3,06 ± 2,47, and 11% were highly nicotine dependent. The regression analysis showed that the relationship between the nicotine dependence total score and menstrual pain severity was significant (F = 7,168; p = 0,008 < 0.05). The nicotine dependence total score increased the level of menstrual pain severity (ß=0,106).
Conclusion
This study demonstrated that smoking may be a risk factor for menstrual irregularities and that the level of nicotine dependency affects the severity of dysmenorrhea.
An innovative method for occluding the urethral meatus and accessing urethra strictures in retrograde urethrography in males
Authors: Li Wei , Man Libo , Huang Guanglin 
Published: August 2023

Abstract
Objectives: To observe and evaluate the effectiveness and safety of using a sponge plug method to occlude the urethral meatus during retrograde urethrography (RUG) for accessing male urethral strictures.
Methods: 40 male patients with a mean age of 51.4 years and a history of urethral injury were primarily diagnosed with urethral stricture using a urethrocystoscope. RUG was performed using a ureteral catheter with a sponge plug inserted into the external meatus. Iodixanol, a contrast medium, was injected into the urethra or bladder for performing RUG and voiding cystourethrography (VCUG). The patients were positioned obliquely to obtain urethrograms.
Results: All X-ray radiologic procedures for performing urethrography were successful without any overflow of contrast liquid observed. In all cases, the sponge plugs became visible in the resulting images. The external meatuses were directly visualized in all cases on the obtained images, allowing identification of the number, location, and length of strictures as well as coexistent pathologies such as fistulas. In one case, the plug slipped off the meatus immediately after completing the procedure. The pain Visual Analogue Scale (VAS) was 0 to 2, mean 0.35. No instances of complication or adverse reactions was observed.
Conclusions: The sponge plug effectively occludes the external urethral meatus for retrograde urethrography, enabling visualization of the actual caliber of the entire urethra, including the strictures and external meatus, by filling it with contrast liquid. This technique is safe and well-tolerated by patients.
Perceived patient safety culture and its associated factors among clinical managers of tertiary hospitals: A cross-sectional survey
Authors: He Haiyan , Chen Xi , Tian Lingyun , Long Yanfang , Li Li , Yang Ning , Tang Siyuan 
Published: August 2023

Abstract
Background
Patient safety is a global challenge influenced by perceived patient safety culture. However, limited knowledge exists regarding the patient safety culture perceived by hospital clinical managers and its associated factors. This study aims to investigate the perceptions of patient safety culture and associated factors among clinical managers of tertiary hospitals in China.
Methods
A cross-sectional survey was conducted from June 19 to July 16 in 2021, involving 539 clinical managers from four tertiary hospitals in Changsha. The Hospital Survey on Patient Safety Culture (HSOPSC) was utilized to assess perceived patient safety culture. Bivariate, multivariable linear regression, and logistic regression analyses were performed.
Results
The mean score for the total HSOPSC was 72.5 ± 7.6, with dimensional scores ranging from 62.1 (14.9) to 86.6 (11.7). Three dimensions exhibited positive response rates (PRRs) < 50%, indicating areas that need to be improved: “nonpunitive response to errors” (40.5%), “staffing” (41.9%), and “frequency of events reported” (47.4%). Specialized hospitals (β = 1.744, P = 0.037), female gender (β = 2.496, P = 0.003), higher professional title (β = 1.413, P = 0.049), a higher education level (β = 1.316, P = 0.001), and shorter time delays per shift (β=-1.13, P < 0.001) were correlated with higher perceived patient safety culture. Education level, work department, “teamwork within a unit”, “management support for patient safety”, “communication openness”, and “staffing” dimensions were associated with patient safety grades (all P < 0.05). Working years in hospitals, occupations, education level, work departments, hospital nature, professional title, “communication openness”, and “handoffs & transitions” dimensions were associated with the number of adverse events reported (all P < 0.05).
Conclusions
Our study revealed a generally low level of patient safety culture perceived by clinical managers and identified priority areas requiring urgent improvement. The associated factors of patient safety culture provide important guidance for the development of targeted interventions in the future. Promoting patient safety by optimizing the patient safety culture perceived by clinical managers should be prioritized.
ZIF-8-incorporated Cellulose Air Filter for Carbon Dioxide Capture
Authors: Singh Angaraj , Singh Aman , Vedrtnam Ajitanshu , Wdowin Magdalena 
Published: August 2023

Abstract
ZIF-8 (zeolitic imidazolate framework-8) has emerged as a highly promising material for CO2 capture due to its outstanding adsorption capacity and selectivity. In the present study, ZIF-8 and a ZIF-8-based cellulose air filter (ZCAF) were synthesized using a rapid synthesis route and the kraft pulping method, respectively. The synthesized ZIF-8 and ZCAF samples were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The SEM analysis revealed a rhombic dodecahedron morphology characterized by rough and porous features, while energy-dispersive X-ray (EDX) analysis confirmed the presence of constituent elements. Furthermore, XRD analyses demonstrated that all observed peaks and bands aligned with the crystalline structure present in the prepared samples. The particle size of the synthesized ZIF-8 samples varied based on the synthesis parameters, measuring approximately 99.46 nm, 101.9 nm, and 105.7 nm. To develop a ZIF-8-based air filter for CO2 capture, the ZIF-8 crystals were incorporated into a filter medium. The resulting ZIF-8-based air filter demonstrated significant improvements in CO2 loading compared to the standard MEA (monoethanolamine) reference. The calculated percentage increase in CO2 loading was approximately 41% for ZIF-8 (ZS3) and 22% for ZCAF (ZCAF3) samples respectively, relative to the MEA reference.
Effect of Biofilm Formation on the Color Properties of CAD/CAM Materials
Authors: Topçu Sümeyra , Özcelik Eda Yazıcı , Kopuz Dilan , Kolaylı Fetiye , Tekçe Neslihan , Demirci Mustafa , Tuncer Safa 
Published: August 2023

AbstractObjectivesTo investigate the effect of biofilm formation on the coloration properties of CAD/CAM materials.Materials and Methods106 samples of 2-mm thickness were prepared from two different CAD/CAM materials (IPS e.max CAD; Cerasmart) and a total of 53 samples were prepared from extracted caries-free human-teeth. Five samples from each sample group were used to measure the amount of alive biomass in the biofilm. The remaining 48 samples in each group were divided into four subgroups: group-1, kept in water without the formation of dental biofilm; group-2, kept in tea without the formation of dental biofilm; group-3, kept in water after the formation of dental biofilm; group-4: kept in tea after the formation of dental biofilm (n=12). After finishing and polishing, color and surface roughness measurements were made. After baseline measurements, a biofilm layer was formed in groups-3 and 4, and the measurements were repeated. Afterward, all samples were brushed, and a third measurement was performed. Data were statistically analyzed (p<0.05).ResultsThe lowest roughness value was observed in Cerasmart. Tooth-IPS e.max CAD gave similar results. The Cerasmart material had the most viable biomass, whereas the IPS e.max CAD material had the least. Group-4 had the highest ΔE1 value for all materials and group-1 had the lowest. The presence of biofilm on CAD/CAM materials immersed in water caused an unacceptable degree of coloration (ΔE>1.8), and immersion in tea caused much more color change.ConclusionsThe brushing process allowed CAD/CAM materials to return to their original color.Clinical RelevanceThe adhesion of biofilm to restorative dental materials plays an important role in the coloring of dental treatment.
Anthropogenic Influence and Climate Change: Water and Nutrient Dynamics in the Kebir- Rhumel Basin, (Northeastern Algeria)
Authors: Bouchareb Noureddine , Bousbia Sabri , Lefilef Abdelhak , Akboudj Alaeddine , Chardib Marwa , Bouguenna Rawiya 
Published: August 2023

Abstract
This study investigates Anthropogenic Influence and Climate Change: Water and Nutrient Dynamics in the Kebir-Rhumel Basin in Northeastern Algeria. Integrating 10 physicochemical variables, a PCA analysis highlights two distinct factors accounting for 80.90% of the total variance and identifies a strong positive correlation between various variables, particularly NH4 and PO4. Two contrasting river areas were noted: Oued Radjas and Oued Rhumel rivers, displaying evidence of anthropogenic activities, and Oued Kebir and Oued El-Kotone rivers, indicative of pristine conditions. Seasonal fluctuations were noted in atmospheric temperature, precipitation, humidity, and wind speed, as well as in physical parameters and nutrient concentrations of surface water, suggesting the potential impact of human activities on water quality and ecosystem health. High EC and TDS values in the Oued Radjas River point to anthropogenic pollution, and high nitrogen nutrient concentrations in the Oued El-Kotonne River hint at potential eutrophication. The study underscores the importance of understanding the interplay between human activities and natural processes in managing water resources and ecosystems. Further research is needed to identify specific human contributors to water quality degradation and nutrient imbalances and to explore mitigation measures for sustainable development.
Exploring the use of nanofluids in pump-free systems for solar thermal applications
Authors: Kosinska Anna , Balakin Boris V. , Kosinski Pawel 
Published: August 2023

Abstract
By using nanofluids as a working fluid in pump-free designs, thermal energy systems can become more efficient and have reduced maintenance costs, ultimately extending the system’s lifespan. In this paper, our goal is to investigate unsteady phenomena in the irradiation process and highlight their significance. To accomplish this, we conducted a series of experiments using a square loop of glass pipes filled with carbon black nanofluids and irradiated with a halo-gen lamp to simulate solar irradiation. The resulting convective motion of the nanofluids allowed us to observe the performance of different concentrations of carbon black, with 0.005-0.01 wt.% proving to be the most effective. Additionally , we identified unsteady processes that occur at the beginning of the process or when the irradiation changes. Finally, we employed computational fluid dynamics simulations to gain further insight into these phenomena.
A Hybrid Multi-objective Optimization Approach for Warehouses Location Problem
Authors: Mankour Ikram , Yachba Khadidja 
Published: August 2023

Abstract

Many recent studies show that supply chain design positively impacts logistics performance and cost. Companies today are forced to make many types of decisions to ensure their medium- and long-term survival. Many issues are raised by this practice, such as the optimization of the supply chain. Our work is mainly focused on the research of distribution of products to customers. This network is made up of customers and warehouses. We suggest in this study a new method for selecting potential warehouses based on the particle swarm algorithm, which is a metaheuristic method. The proposed method, HWS-MOPSO (Hybrid Warehouse Selection Multi-Objective Particle Swarm Optimization), is a hybrid method based on two essential methods. The first step is to gather nearby customers using an unsupervised learning method. The second step is choosing the best warehouse location. This method makes it easier to perform three objectives. Finally, the analysis of its performance is carried out in a set of customers and warehouses. The test results demonstrate that the suggested method is effective and can select several warehouses (variables) and maintain the best cost, distance, and delay.
Plasma and Urinary Metabolomic Analysis of Gout and Asymptomatic Hyperuricemia and Profiling of Potential Biomarkers: A Pilot Study
Authors: Ohashi Yuki , Oyama Hiroshi , Makinoshima Hideki , Takada Tappei , Matsuo Hirotaka , Ichida Kimiyoshi 
Published: August 2023

Abstract
Gout results from monosodium urate deposition caused by hyperuricemia, but most individuals with hyperuricemia remain asymptomatic. The pathogenesis of gout remains uncertain. To identify potential biomarkers distinguishing gout from asymptomatic hyperuricemia, we conducted genetic analysis of urate transporters and metabolomic analysis as a proof-of-concept study including 33 patients with gout and 9 individuals with asymptomatic hyperuricemia. The variant allele frequencies of rs72552713, rs2231142, and rs3733591, which are related to serum urate levels (SUA) and gout, did not differ between the gout and asymptomatic hyperuricemia groups. In metabolomic analysis, the levels of citrate cycle intermediates, especially 2-ketoglutarate, were higher in patients with gout than in those with asymptomatic hyperuricemia (fold difference = 1.415, p = 0.039). The impact on the tricarboxylate (TCA) cycle was further emphasized in high-risk gout (SUA ≥ 9.0 mg/dL). Of note, urinary nicotinate was the most prominent biomarker differentiating high-risk gout from asymptomatic hyperuricemia (fold difference = 6.515, p = 0.020). Although urate transporters play critical roles in SUA elevation and promote hyperuricemia, this study suggests that the progression from asymptomatic hyperuricemia to gout might be closely related to other genetic and/or environmental factors affecting carbohydrate metabolism and urinary urate excretion.
Micro-CT-based HTPB propellant double-axis stretch test design
Authors: Chen Tiezhu , Qiang Hongfu , Wang Xueren , Wang Zhejun , Wang Jiaxiang , Li Shiqi , Yuan Bin 
Published: August 2023

Abstract
In order to study the microstructural damage evolution of solid propellants under biaxial tension, firstly, based on finite element numerical calculation, small specimens of HTPB propellant that can simultaneously meet the requirements of biaxial deformation characteristics were designed, and stress cloud maps of deformation were obtained for three different configurations of HTPB propellant small specimens under typical tensile ratios. Then, based on the 1172 Micro-CT and its corresponding biaxial tensile fixture, biaxial tensile microtests were conducted to verify the confirmed configuration of small specimens. The results show that under the same loading displacement conditions, the stress distribution in the central test area of the three configurations of small HTPB propellant specimens is relatively uniform. The average stress value, plane stress dispersion, and overall stress stability coefficient of the central test area are calculated, and the optimal configuration of the small specimen with a thinning radius of R = 2 mm in the center circle is analyzed and compared. The central test area shows a more significant biaxial tensile state; the damage evolution process of the microstructure of small specimens was obtained through biaxial tensile tests, and the changes in force and porosity of small specimens with loading displacement were obtained. Finally, by analyzing the experimental results, the design requirements for small specimens of HTPB propellant under biaxial tension were met, and the rationality and effectiveness of the small specimen configuration were verified.
Heart Disease Prediction System Using Machine Learning Algorithms (KNN and Decision Tree Algorithm)
Authors: lone zainab Fayaz Fayaz ahmad , Hod saurabh 
Published: August 2023

Abstract
Heart disease is a critical issue in the field of medical science, and accurate prediction plays a crucial role in improving patient outcomes. In recent years, machine learning algorithms have emerged as powerful tools for predicting disease. This thesis aims to produce and compare two popular machine learning algorithms K-Nearest Neighbors (KNN) and Decision Tree for Heart. Heart disease prediction