bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of economic context and reward amount on delay and probability discounting
Authors: Anderson Molly A. B. , Cox David J. , Dallery Jesse 
Published: June 2023

AbstractSteep delay and shallow probability discounting are associated with myriad problem behaviors; thus, it is important to understand factors that influence the degree of discounting. The present study evaluated the effects of economic context and reward amount on delay and probability discounting. Two hundred thirteen undergraduate psychology students completed four delay‐ or probability‐discounting tasks. Participants were exposed to hypothetical narratives involving four bank amounts ($750, $12,000, $125,000, and $2,000,000). The delayed/probabilistic amount was $3,000 for the two smaller bank amounts and $500,000 for the two larger bank amounts. The discounting tasks included five delays to, or probabilities of, receipt of the larger amount. The area under the empirical discounting function was calculated for each participant. Participants discounted delayed and uncertain outcomes more when the bank amount was smaller than the outcome (i.e., the economic context was low). Participants discounted the delayed larger amounts less than delayed smaller amounts, even when the relative economic context was the same. In contrast, probability discounting did not differ across magnitudes, which suggests that economic context may attenuate the magnitude effect in probability discounting. The results further highlight the importance of considering the economic context in delay and probability discounting.
Peptidome‐wide association analysis of Epstein−Barr virus identifies epitope repertoires associated with nasopharyngeal carcinoma
Authors: Deng Chang‐Mi , Wang Tong‐Min , He Yong‐Qiao , Zhang Wen‐Li , Xue Wen‐Qiong , Li Dan‐Hua , Yang Da‐Wei , Wang Qiao‐Ling , Liao Ying , Diao Hua , Jiang Cheng‐Tao , Zhang Jiang‐Bo , Yuan Lei‐Lei , Chen Xue‐Yin , Zhou Ting , Li Xi‐Zhao , Zhang Pei‐Fen , Zheng Xiao‐Hui , Zhang Shao‐Dan , Hu Ye‐Zhu , Xu Miao , Zeng Mu‐Sheng , Feng Lin , Jia Wei‐Hua 
Published: June 2023

AbstractHuman leukocyte antigen (HLA) molecules are essential for presenting Epstein−Barr virus (EBV) antigens and are closely related to nasopharyngeal carcinoma (NPC). This study aims to systematically investigate the association between HLA‐bound EBV peptides and NPC risk through in silico HLA‐peptide binding prediction. A total of 455 NPC patients and 463 healthy individuals in NPC endemic areas were recruited, and HLA‐target sequencing was performed. HLA‐peptide binding prediction for EBV, followed by peptidome‐wide logistic regression and motif analysis, was applied. Binding affinity changes for EBV peptides carrying high‐risk mutations were analyzed. We found that NPC‐associated EBV peptides were significantly enriched in immunogenic proteins and core linkage disequilibrium (LD) proteins related to evolution, especially those binding HLA‐A alleles (p = 3.10 × 10−4 for immunogenic proteins and p = 8.10 × 10−5 for core LD proteins related to evolution). These peptides were clustered and showed binding motifs of HLA supertypes, among which supertype A02 presented an NPC‐risk effect (padj = 3.77 × 10−4) and supertype A03 presented an NPC‐protective effect (padj = 4.89 × 10−4). Moreover, a decreased binding affinity toward risk HLA supertype A02 was observed for the peptide carrying the NPC‐risk mutation BNRF1 V1222I (p = 0.0078), and an increased binding affinity toward protective HLA supertype A03 was observed for the peptide carrying the NPC‐risk mutation BALF2 I613V (p = 0.022). This study revealed the distinct preference of EBV peptides for binding HLA supertypes, which may contribute to shaping EBV population structure and be involved in NPC development.
The role of periodontitis‐associated bacteria in Alzheimer's disease: A narrative review
Authors: Eslami Saba , Hosseinzadeh Shakib Nafiseh , Fooladfar Zahra , Nasrollahian Sina , Baghaei Saman , Mosaddad Seyed Ali , Motamedifar Mohammad 
Published: June 2023

AbstractAlzheimer's disease causes memory loss and dementia in older adults through a neurodegenerative mechanism. Despite the pathophysiological clarification of this cognitive disorder, novel molecular and cellular pathways should be identified to determine its exact mechanism. Alzheimer's disease (AD) is pathologically characterized by senile plaques comprising beta‐amyloid and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau as a microtubule‐associated protein with a key role in the pathogenesis of AD. Periodontitis through inflammatory pathways is a risk factor for deteriorating cognitive impairment in AD patients. Poor oral hygiene coupled with immunocompromised status in older adults causes periodontal diseases and chronic inflammations through an oral bacterial imbalance. Toxic bacterial products, including bacteria themselves, can reach the central nervous system through the bloodstream and evoke inflammatory responses. The present review was conducted to investigate relationships between AD and periodontitis‐involved bacteria as a risk factor.
Selective removal of Pb(II) from yellow rice wine using magnetic carbon‐based adsorbent
Authors: Shao Zhiying , Xing Changrui , Xue Mei , Fang Yong , Li Peng 
Published: June 2023

AbstractBACKGROUNDThe non‐distilled property and prolonged production period of yellow rice wine have significantly increased the metal residue problem, posing a threat to human health. In this study, a magnetic carbon‐based adsorbent, named magnetic nitrogen‐doped carbon (M‐NC), was developed for the selective removal of lead(II) (Pb(II)) from yellow rice wine.RESULTSThe results showed that the uniformly structured M‐NC could be easily separated from the solution, exhibiting a high Pb(II) adsorption capacity of 121.86 mg g−1. The proposed adsorption treatment showed significant Pb(II) removal efficiencies (91.42–98.90%) for yellow rice wines in 15 min without affecting their taste, odor, and physicochemical characteristics of the wines. The adsorption mechanism studied by X‐ray photoelectron spectroscopy (XPS) and Fourier‐transform infrared (FTIR) analyses indicated that the selective removal of Pb(II) could be attributed to the electrostatic interaction and covalent interaction between the empty orbital of Pb(II) and the π electrons of the N species on M‐NC. Additionally, the M‐NC showed no significant cytotoxicity on the Caco‐2 cell lines.CONCLUSIONSelective removal of Pb(II) from yellow rice wine was achieved using magnetic carbon‐based adsorbent. This facile and recyclable adsorption operation could potentially address the challenge of toxic metal pollution in liquid foods. © 2023 Society of Chemical Industry.
VExUS Score in the Management of Patients With Acute Kidney Injury in the Intensive Care Unit: AKIVEX Study
Authors: Rihl Marcos Frata , Pellegrini José Augusto Santos , Boniatti Márcio Manozzo 
Published: June 2023

ObjectivesVenous congestion is a potential cause of acute kidney injury (AKI) and venous excess ultrasound (VExUS) score is a potentially useful tool in this scenario. The aim of this study is to verify whether the VExUS score can serve as a guide to decongestion in patients with severe AKI and whether the modification of the score can be associated with an increase in the number of renal replacement therapy (RRT)‐free days in 28 days.MethodsThis quasi‐experimental study was conducted in patients admitted to the intensive care unit who developed severe AKI. The intervention was to suggest to the attending physician the use of diuretic in patients with VExUS >1. After 48 hours, a new VExUS assessment was performed. Primary outcome was RRT‐free days at Day 28.ResultsNinety patients were included. Patients with a VExUS score >1 (n = 36) at enrollment had a greater use of diuretics in the following 48 hours (75.0%, n = 27) than patients with a VExUS ≤1 (n = 54) at enrollment (38.9%, n = 21), P = .001. Patients who reduced the VExUS score had a significantly greater number of RRT‐free days at Day 28 (28.0; 8.0–28.0) when compared with those who did not reduce (15.0; 3.0–27.5), P = .012.ConclusionsWe found a higher diuretic use in patients with a higher VExUS score, and patients who reduced the VExUS in 48 hours had significantly more RRT‐free days in 28 days.
Interaction between rhizobacterial community and host root determines poplar salt tolerance
Authors: Liao Yangwenke , Cao Chaoyang , Zhang Qingyue , Zhang Peiyao , Li Xiaogang 
Published: June 2023

AbstractRhizosphere microbes play important roles in plant tolerance to abiotic stresses. Plants of different genetic backgrounds acquire stress resistance by assembling specific rhizosphere microbial communities or typical beneficial microbiota. However, the molecular mechanisms by which plants recruit microbiota during plant acclimation to environmental stresses are unclear. Here, we investigated transcription pattern in three poplar genotypes, namely Populus davidiana × P. bolleana Loucne (SXY), P. deltoides × P. euramericana ‘Nanlin 895’ (NL895) and P. alba × P. glandulosa ‘84K’ (84K), and their effect on the rhizosphere microbial community under salinity. The results showed that SXY exhibited salt tolerance characterized by the best performance of photosynthesis and antioxidant system upon salt stress, while salt stress severely damaged the growth and membrane system of 84K. 16S rRNA sequencing revealed the lowest rhizobacterial community diversity associated with SXY compared to 84K and NL895, implying strong enrichment of certain bacterial taxa by the salt tolerant cultivar. Specifically, SXY recruited higher abundances of Hydrogenophaga and Pseudomonas. Furthermore, RNA‐seq analysis of roots combined with weighted gene co‐expression network analysis (WGCNA) identified module eigengene (ME)yellow, a module positively correlated to the SXY‐enriched OTUs. KEGG analysis revealed significant enrichment of lipid metabolic and amino acid biosynthetic pathways in MEyellow. Twenty‐four genes selected from the pathways enriched in MEyellow showed the highest expression levels in SXY. Our results suggest a “gene expression‐rhizosphere‐microbiota‐salt tolerance” regulatory process in the poplar under salinity and provide new insights into the mechanisms by which plants shape the soil microbiome to improve salt tolerance.
Patient tolerance in office‐based blue laser therapy for lesions of the vocal folds: Correlation with patients' characteristics, disease type and procedure‐related factors
Authors: Hamdan Abdul‐Latif , Hosri Jad , Abou Raji Feghali Patrick , Ghanem Anthony , Fadel Charbel , Jabbour Christopher 
Published: June 2023

AbstractObjectiveTo report patient tolerance in office‐based blue laser therapy for vocal fold lesions.MethodsA retrospective review of the medical records of patients who underwent office‐based blue laser therapy for lesions of the vocal folds between November 2021 and February 2023 was conducted. A total of 48 patients were included. Patient tolerance was assessed using the Iowa Satisfaction with Anesthesia Scale (IOWA). Patient tolerance was analyzed in relation to patients' demographic characteristics, disease type and severity, and procedure‐related factors.ResultsThe mean tolerance score of the study group was 1.51 ± 1.1. There was a significant difference in the mean tolerance score between smokers and non‐smokers (p = .038). Patients with vocal fold cyst (n = 3) had the highest mean tolerance score followed by patients with vocal fold polyps (n = 15). There was a nonsignificant difference in the mean tolerance score between benign lesions of the vocal folds and leukoplakia. Patients with lesions extending to more than half the vocal fold had less tolerance than those with lesions limited to less than half the vocal fold (1.91 vs. 1.27, p value .041). There was a moderate and significant negative correlation between vocal fold movement VAS, swallowing VAS, and tolerance score. The mean total duration of the procedures was 10.38 ± 4.8 min. There was a mild negative correlation between the duration of the procedure and tolerance.ConclusionOffice‐based blue laser therapy for vocal fold lesions is a well‐tolerated procedure. Patient should be instructed how to breathe quietly and avoid swallows to improve tolerance to surgery.Level of Evidence4.
Lifelong Association of Disorders Related to Military Trauma with Subsequent Parkinson's Disease
Authors: Scott Gregory D. , Neilson Lee E. , Woltjer Randy , Quinn Joseph F. , Lim Miranda M. 
Published: June 2023

ABSTRACTBackgroundTrauma‐related disorders such as traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are emerging as risk factors for Parkinson's disease (PD), but their association with development of PD and independence from comorbid disorders remains unknown.ObjectiveTo examine TBI and PTSD related to early trauma in military veterans using a case‐control study.MethodsPD was identified by International Classification of Diseases (ICD) code, recurrent PD‐specific prescriptions, and availability of 5+ years of earlier records. Validation was performed by chart review by a movement disorder–trained neurologist. Control subjects were matched 4:1 by age, duration of preceding health care, race, ethnicity, birth year, and sex. TBI and PTSD were identified by ICD code and onset based on active duty. Association and interaction were measured for TBI and PTSD with PD going back 60 years. Interaction was measured for comorbid disorders.ResultsA total of 71,933 cases and 287,732 controls were identified. TBI and PTSD increased odds of subsequent PD at all preceding 5‐year intervals back to year −60 (odds ratio range: 1.5 [1.4, 1.7] to 2.1 [2.0, 2.1]). TBI and PTSD showed synergism (synergy index range: 1.14 [1.09, 1.29] to 1.28 [1.09, 1.51]) and additive association (odds ratio range: 2.2 [1.6, 2.8] to 2.7 [2.5, 2.8]). Chronic pain and migraine showed greatest synergy with PTSD and TBI. Effect sizes for trauma‐related disorders were comparable with established prodromal disorders.ConclusionsTBI and PTSD are associated with later PD and are synergistic with chronic pain and migraine. These findings provide evidence for TBI and PTSD as risk factors preceding PD by decades and could aid in prognostic calculation and earlier intervention. © 2023 International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.
Characterization and Pharmacokinetic Profile of Herbs and Spices' Phytochemicals over 24 h after Consumption in Overweight/Obese Adults
Authors: Huang Yudai , Edirisinghe Indika , Burton‐Freeman Britt M. , Sandhu Amandeep K. 
Published: June 2023

ScopeThis study aims to characterize the phytochemicals in commonly consumed herbs/spices (H/S) in the United States and their pharmacokinetic profile (PK) over 24 h in humans after consumption.Method and resultsThe clinical trial is a randomized, single‐blinded, four‐arm, 24 h, multi‐sampling, single‐center crossover design (Clincaltrials.gov NCT03926442) conducted in obese/overweight adults (n = 24, aged 37 ± 3 years, BMI = 28.4 ± 0.6 kg m−2). Study subjects consume a high‐fat high‐carbohydrate meal with salt and pepper (control) or the control meal with 6 g of three different H/S mixtures (Italian herb: rosemary, basil, thyme, oregano, and parsley in the same ratio; cinnamon; and pumpkin pie spice containing cinnamon, ginger, nutmeg, and allspice, the ratio is unknown). Three H/S mixtures are analyzed and 79 phytochemicals are tentatively identified and quantified. Following H/S consumption, 47 metabolites are tentatively identified and quantified in plasma samples. The PK data suggest that some metabolites appear in blood as early as 0.5 h while others can extend up to 24 h.ConclusionPhytochemicals from H/S include in a meal are absorbed and undergo phase I and phase II metabolism and/or catabolized to phenolic acids peaking at different times.
Simultaneous activation of Kras–Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway
Authors: Namikawa Mio , Fukuda Akihisa , Mizukoshi Kenta , Iwane Kosuke , Kawai Munenori , Yamakawa Go , Omatsu Mayuki , Sono Makoto , Masuda Tomonori , Araki Osamu , Nagao Munemasa , Yoshikawa Takaaki , Ogawa Satoshi , Hiramatsu Yukiko , Muta Yu , Tsuda Motoyuki , Maruno Takahisa , Nakanishi Yuki , Tsuruyama Tatsuaki , Taura Kojiro , Hatano Etsuro , Seno Hiroshi 
Published: June 2023

AbstractBiliary tract cancer (BTC) has poor prognosis. The Notch receptor is aberrantly expressed in extrahepatic cholangiocarcinoma (eCCA). However, the role of Notch signaling in the initiation and progression of eCCA and gallbladder (GB) cancer remains unknown. Therefore, we investigated the functional role of Notch signaling during tumorigenesis of the extrahepatic bile duct (EHBD) and GB. Activation of Notch signaling and oncogenic Kras resulted in the development of biliary intraepithelial neoplasia (BilINs) in the EHBD and GB, which were premalignant lesions that progressed to adenocarcinoma in mice. The expression of genes involved in the mTORC1 pathway was increased in biliary spheroids from Hnf1b‐CreERT2; KrasLSL‐G12D; Rosa26LSL‐NotchIC mice and inhibition of the mTORC1 pathway suppressed spheroid growth. Additionally, simultaneous activation of the PI3K–AKT and Notch pathways in EHBD and GB induced biliary cancer development in mice. Consistent with this, we observed a significant correlation between activated NOTCH1 and phosphorylated Ribosomal Protein S6 (p‐S6) expression in human eCCA. Furthermore, inhibition of the mTORC1 pathway suppressed the growth of Notch‐activated human biliary cancer cells in vitro and in vivo. Mechanistically, the Kras/Notch–Myc axis activated mTORC1 through TSC2 phosphorylation in mutant biliary spheroids. These data indicate that inhibition of the mTORC1 pathway could be an effective treatment strategy for Notch‐activated human eCCA. © 2023 The Pathological Society of Great Britain and Ireland.
Capillary surface modification using millimolar levels of aminosilane reagent for highly efficient separation of phenolic acids and flavonols by capillary electrophoresis with UV detection
Authors: Hemwech Pattamaporn , Obma Apinya , Detsangiamsak Sasinun , Wirasate Supa , Wilairat Prapin , Chantiwas Rattikan 
Published: June 2023

AbstractIntroductionPhytochemical analysis of phenolic acids and flavonols poses a challenge, necessitating the development of an efficient separation method. This facilitates the quantification of these compounds, yielding valuable insights into their benefits.ObjectiveTo develop a highly effective separation of phenolic acids and flavonols by capillary electrophoresis and ultraviolet (UV) detection through the modification of the capillary surface using 3‐aminopropyltriethoxysilane (APTES) at millimolar concentrations.MethodsThe capillary surface is modified with 0.36 mM‐APTES solution. The electrolyte is 20.0 mM borate buffer (pH 9.0). Separation performance (plate number N, resolution Rs), stability, and reproducibility of the coating procedure are evaluated using the analysis of phenolic acids, rutin and quercetin.ResultsThe modified capillary provided efficient separation with plate numbers N ≥ 1.0 × 104 m−1 and resolution Rs ≥ 0.8 for all pairs of adjacent peaks of the separation of five selected phenolic acids, rutin, quercetin, caffeine and methylparaben (as internal standard). The precisions of the relative migration times for 17 consecutive analyses of samples over 3 h were 1% relative standard deviation (RSD) for rutin and 7% RSD for quercetin. The analysis of rutin and quercetin in 12 dietary supplement product samples only required a simple dilution step for sample preparation.ConclusionA straightforward modification technique utilising millimolar concentrations of APTES resulted in highly efficient separation of phenolic acids, rutin and quercetin, accompanied by high precision and surface stability. The modified capillary proved successful in analysing rutin and quercetin content in dietary supplements.
Degradation of high density polyethylene packaging by accelerated aging in sea water
Authors: Elkori Rabiaa , Lamarti Amal , Salmi Houda , Hachim Abdelilah , El had Khalid 
Published: June 2023

AbstractThe increase of plastic waste in the marine environment raises several ecological, human, and biological problems. In this work, an accelerated artificial aging study was conducted in seawater after immersing samples of high‐density polyethylene bottles for several aging times and at three different temperatures. The deterioration of the mechanical properties of High density polyethylene (HDPE) under different aging conditions was investigated using tensile and compression tests. The absorption of seawater by the samples was analyzed using a gravimetric method and Fourier transform infrared spectrometry (FTIR). Further surface analysis of the samples during accelerated aging was performed using a scanning electron microscope. The results show that HDPE loses its ductility and rigidity. FTIR analysis confirms the increase in crystallinity during aging.
Chloramines of amino acids as precursors of bactericidal activity in cell culture media DMEM and RPMI treated by RF‐driven He/O2 plasma jet
Authors: Jirásek Vít , Tarabová Barbora , Lukeš Petr 
Published: June 2023

AbstractAntibacterial properties and chemical changes of two culture media, Dulbecco's Modified Eagle Medium (DMEM) and Roswell Park Memorial Institute (RPMI), treated by RF‐driven He/O2 plasma jet, were studied using various chemical diagnostics and assessing Escherichia coli inactivation. The antibacterial effect increased with the plasma treatment time and was stronger in RPMI than in DMEM. Formation of organic mono‐ and dichloramines of amino acids in DMEM/RPMI by hypochlorite produced by the reaction of plasma‐generated O atoms with Cl− ions present in culture media were the major causes of the biocidal activity. This behavior was attributed to the action of tertiary chemical products formed by the decay of organic dichloramines. The thiobarbituric acid assay revealed malondialdehyde formation from glucose oxidation as the major component of the media.