bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Control and Weight Loss After Bariatric Surgery: the BARICO Study
Authors: Custers Emma , Vreeken Debby , Kaufmann Lisa-Katrin , Pujol-Gualdo Natalia , Asbreuk Marije , Wiesmann Maximilian , Aarts Esther , Hazebroek Eric J. , Kiliaan Amanda J. 
Published: July 2023

Abstract
Background and Objectives
Bariatric surgery (BS) is an effective treatment for obesity. However, some individuals experience insufficient weight loss after surgery. Therefore, we investigated whether cognitive control affects weight loss after Roux-en-Y gastric bypass (RYGB).

Methods
Within this exploratory observational study, part of the BARICO study (BAriatric surgery Rijnstate and Radboudumc neuroImaging and Cognition in Obesity), participants aged between 35 and 55 years eligible for RYGB were included. Before and after BS, body weight, (delta) BMI and percentage total body weight loss (%TBWL) were determined. Additionally, at baseline, Stroop task-performance, -activation and -connectivity were assessed by a color-word paradigm task during functional neuroimaging to determine the ability of participants to inhibit cognitive interference.

Results
Seventy-six participants were included, of whom 14 were excluded from fMRI analysis, leaving 62 participants. Participants were aged 45.0 ± 5.9 years with a mean pre-surgery BMI of 40.2 ± 3.3 kg/m2, and 86% were women. Mean decrease in BMI was 13.8 ± 2.5 kg/m2, and mean %TBWL was 34.9 ± 6.3% 1 year after BS. Stroop task performance did not correlate with (delta) BMI and %TBWL. The inferior parietal/middle occipital gyrus, inferior frontal gyrus, and supplementary motor cortex were involved in cognitive interference, although activity in these regions did not predict weight loss after surgery. Lastly, generalized psychophysiological interaction did not provide evidence for (delta) BMI- and %TBWL-dependent connectivity modulation.

Discussion
Cognitive control did not predict weight loss after surgery. Future studies should focus on longer follow-up periods to understand the relation between cognitive control and weight loss.

Trial Registration
NL7090 (https://www.clinicaltrialregister.nl/nl/trial/28949)

Graphical Abstract
Spatial Patterns and Health-Based Characterization of the Retail Food Environment in Mexico City
Authors: Ortega-Avila Ana G. 
Published: July 2023

AbstractThe public health burden of obesity and non-communicable diseases in Mexico is one of the highest in the world, and one of its main causes is the change in diet of the population. The urban food environment has been suggested as a key contributor towards the increasing deterioration in diets. Our objective was to present the first spatial and health characterization of the food environment of Mexico City. The data source was the National Statistics Directory of Economic Units 2020, which provides data on the urban supply of food and beverages. Food outlets were classified into 14 types according to the food items that are mainly sold. Local spatial autocorrelation methods were used to assess the existence of spatial patterns. The results suggest all types of food outlet showed high- density clusters and low -density clusters, with the geographic location of these clusters varying based on the type of establishment and by socioeconomic status of the census tracts. This paper puts forward a health-based classification of food retail outlets, to identify the spatial distribution of food outlets in relation to nutrition and health. This could guide researchers and policymakers towards improvements, particularly to direct interventions towards specific areas of the city.
How two leading partners learn to tango: The case of IoT-based business model co-innovation between a retailer and an electronics supplier
Authors: Sturm Michael , Weking Jörg , Böhm Markus , Schreieck Maximilian , Krcmar Helmut 
Published: July 2023

AbstractDue to eroding business models, companies are seeking new growth opportunities. Business model innovation (BMI) can enable sustainable competitive advantage and future growth. Yet many companies are struggling to innovate their business models. Recent research reveals that collaboration concerning stakeholder integration and open business model innovation can foster BMI, but research has addressed both topics in isolation. By combining these topics, we establish business model co-innovation (BMCI) as a new perspective. Based on a longitudinal case study of an incumbent retailer and an incumbent electronics supplier, we investigate how both parties contribute to innovating the supplier’s business model. We document a BMCI process model highlighting the direct and indirect business model changes of the retailer and the supplier and we identify BMCI characteristics. We contribute to research with a new perspective on how partners co-innovate a business model.
Kinematic tests on a docking mechanism for microsatellites
Authors: Lion Luca , Caon Alex , Olivieri Lorenzo , Branz Francesco , Francesconi Alessandro 
Published: July 2023

AbstractDOCKS is a smart docking system developed within the framework of the Space Rider Observer Cube mission (SROC) but suitable for use in more general scenarios. This paper presents the mechanical design of the system and the kinematic tests performed on it. The system merges a classical probe drogue configuration with a gripper-like design, to manage the connection between the parts, and it is equipped with a suite of sensors to estimate the relative pose of the target. The system is also equipped with a dedicated computer, making it a smart standalone system. A series of kinematic tests have been conducted to validate the capability of the system to passively manage misalignment during the docking manoeuvre. The final tests are presented to assess the maximum load that the system could handle, even when inactive.
Spatial characteristics of food insecurity and food access in Los Angeles County during the COVID-19 pandemic
Authors: Livings Michelle Sarah , Wilson John , Miller Sydney , Bruine de Bruin Wändi , Weber Kate , Babboni Marianna , Xu Mengya , Li Kenan , de la Haye Kayla 
Published: July 2023

AbstractFood insecurity spiked in some U.S. regions during the COVID-19 pandemic, as did food access challenges. Concerns were raised that these food issues were more prominent in food deserts, or neighborhoods lacking access to a grocery store or supermarket. Using data collected from a representative sample of Los Angeles County adults between April and October 2020, this study examined relationships between self-reported food insecurity, perceived food access barriers, and residing in a food desert, and examined differences across key geographic regions of the county. There was little relationship between residing in a food desert and experiencing food insecurity. However, perceived grocery store closures/limited hours and not having access to a vehicle were commonly reported barriers to food access, which were associated with more food insecurity. These findings suggest that geographic disparities in food access impact food insecurity. Efforts to address food insecurity should center on achieving food justice and addressing disparities across geographic regions.
Numerical Study of the Robustness of Steel Frames with Bolted End-Plate Joints Subjected to Sudden and Gradual Internal Column Loss
Authors: Kukla Damian , Kozlowski Aleksander 
Published: July 2023

AbstractThe research project was carried out to estimate the robustness of flat steel-framed structures in a selected accidental situation. For this purpose, a multistage approach based on experimental tests and numerical analysis was performed. As the main objective of the work, a numerical dynamic analysis of the steel frames was performed under a sudden and gradual internal column loss scenario. FEA models were created in Abaqus software using solid and shell elements. Computer analyzes were carried out in a number of different cases, taking into account the size of the structure, the type of joints, and the method of removing the column from the structure. Detailed results on the axial forces and rotation of the joints under analysis are presented, and the robustness of the structures is estimated. In all cases of frames with flush end-plate joints, an insufficient level of robustness was observed and failures of the structures were obtained. In the cases of application of extended end-plate joints in frame analysis, the required level of robustness was reached in all cases and the stop of collapse was obtained. Finally, practical recommendations for designing robust joints and the whole frame structure are presented.
Norovirus-associated neurological manifestations: summarizing the evidence
Authors: Deb Shramana , Mondal Ritwick , Lahiri Durjoy , Shome Gourav , Roy Aakash Guha , Sarkar Vramanti , Sarkar Shramana , Benito-León Julián 
Published: July 2023

AbstractNorovirus, a positive-stranded RNA virus, is one of the leading causes of acute gastroenteritis among all age groups worldwide. The neurological manifestations of norovirus are underrecognized, but several wide-spectrum neurological manifestations have been reported among infected individuals in the last few years. Our objective was to summarize the features of norovirus-associated neurological disorders based on the available literature. We used the existing PRISMA consensus statement. Data were collected from PubMed, EMBASE, Web of Science, and Scopus databases up to Jan 30, 2023, using pre‐specified searching strategies. Twenty-one articles were selected for the qualitative synthesis. Among these, seven hundred and seventy-four patients with norovirus-associated neurological manifestations were reported. Most cases were seizure episodes, infection-induced encephalopathy, and immune-driven disorders. However, only a few studies have addressed the pathogenesis of norovirus-related neurological complications. The pathogenesis of these manifestations may be mediated by either neurotropism or aberrant immune-mediated injury, or both, depending on the affected system. Our review could help clinicians to recognize these neurological manifestations better and earlier while deepening the understanding of the pathogenesis of this viral infection.
Computerized adaptive test strategies for the matrix reasoning subtest of the Wechsler Adult Intelligence Scale, 4th Edition (WAIS-IV)
Authors: Reise Steven P. , Wong Emily , Block Jared , Widaman Keith F. , Gullett Joseph M. , Bauer Russell M. , Drane Daniel L. , Loring David W. , Umfleet Laura Glass , Wahlstrom Dustin , Enriquez Kristen , Whelan Fiona , Shih Stone , Bilder Robert M. 
Published: July 2023

AbstractObjective:Most neuropsychological tests were developed without the benefit of modern psychometric theory. We used item response theory (IRT) methods to determine whether a widely used test – the 26-item Matrix Reasoning subtest of the WAIS-IV – might be used more efficiently if it were administered using computerized adaptive testing (CAT).Method:Data on the Matrix Reasoning subtest from 2197 participants enrolled in the National Neuropsychology Network (NNN) were analyzed using a two-parameter logistic (2PL) IRT model. Simulated CAT results were generated to examine optimal short forms using fixed-length CATs of 3, 6, and 12 items and scores were compared to the original full subtest score. CAT models further explored how many items were needed to achieve a selected precision of measurement (standard error ≤ .40).Results:The fixed-length CATs of 3, 6, and 12 items correlated well with full-length test results (with r = .90, .97 and .99, respectively). To achieve a standard error of .40 (approximate reliability = .84) only 3–7 items had to be administered for a large percentage of individuals.Conclusions:This proof-of-concept investigation suggests that the widely used Matrix Reasoning subtest of the WAIS-IV might be shortened by more than 70% in most examinees while maintaining acceptable measurement precision. If similar savings could be realized in other tests, the accessibility of neuropsychological assessment might be markedly enhanced, and more efficient time use could lead to broader subdomain assessment.
Metabolism of plant-derived toxins from its insect host increases the success of the entomopathogenic fungus Beauveria bassiana
Authors: Sun Ruo , Hong Benke , Reichelt Michael , Luck Katrin , Mai Duc Tam , Jiang Xingcong , Gershenzon Jonathan , Vassão Daniel Giddings 
Published: July 2023

Abstract
Beauveria bassiana is a soil fungus that parasitizes a large number of arthropod species, including numerous crop pests, causing white muscardine disease and is therefore used as a biological insecticide. However, some insects, such as the cabbage aphid (Brevicoryne brassicae), defend themselves chemically by sequestering dietary pro-toxins (glucosinolates) from their Brassicales host plants. Glucosinolates are accumulated by cabbage aphids and activated to form toxic isothiocyanates when under attack. While isothiocyanate formation protects aphids against most attackers, B. bassiana is still able to infect the cabbage aphid under natural conditions. We therefore investigated how this fungus is able to circumvent the chemical defense system of the cabbage aphid. Here, we describe how B. bassiana infection activates the cabbage aphid defense system, but the resulting toxins are metabolized by B. bassiana via the mercapturic acid pathway, of which the first step is catalyzed by glutathione-S-transferases of low substrate specificity. This detoxification pathway enhances B. bassiana growth when isothiocyanates are present in natural concentrations, and so appears to be an important factor in fungal parasitization of these chemically defended aphids.
The DNA methylation landscape of the human oxytocin receptor gene (OXTR): data-driven clusters and their relation to gene expression and childhood adversity
Authors: Müller Svenja , Sicorello Maurizio , Moser Dirk , Frach Leonard , Limberg Alicia , Gumpp Anja M. , Ramo-Fernandez Laura , Köhler-Dauner Franziska , Fegert Jörg M. , Waller Christiane , Kumsta Robert , Kolassa Iris-Tatjana 
Published: July 2023

AbstractThe oxytocin receptor gene (OXTR) is of interest when investigating the effects of early adversity on DNA methylation. However, there is heterogeneity regarding the selection of the most promising CpG sites to target for analyses. The goal of this study was to determine functionally relevant clusters of CpG sites within the OXTR CpG island in 113 mother-infant dyads, with 58 of the mothers reporting childhood maltreatment (CM). OXTR DNA methylation was analyzed in peripheral/umbilical blood mononuclear cells. Different complexity reduction approaches were used to reduce the 188 CpG sites into clusters of co-methylated sites. Furthermore, associations between OXTR DNA methylation (cluster- and site-specific level) and OXTR gene expression and CM were investigated in mothers. Results showed that, first, CpG sections differed strongly regarding their statistical utility for research of individual differences in DNA methylation. Second, cluster analyses and Partial Least Squares (PLS) suggested two clusters consisting of intron1/exon2 and the protein-coding region of exon3, respectively, as most strongly associated with outcome measures. Third, cross-validated PLS regression explained 7% of variance in CM, with low cross-validated variance explained for the prediction of gene expression. Fourth, substantial mother-child correspondence was observed in correlation patterns within the identified clusters, but only modest correspondence outside these clusters. This study makes an important contribution to the mapping of the DNA methylation landscape of the OXTR CpG island by highlighting clusters of CpG sites that show desirable statistical properties and predictive value. We provide a Companion Web Application to facilitate the choice of CpG sites.
ATAD2 is a driver and a therapeutic target in ovarian cancer that functions by upregulating CENPE
Authors: Guruvaiah Praveen , Chava Suresh , Sun Chiao-Wang , Singh Nirupama , Penn Courtney A. , Gupta Romi 
Published: July 2023

AbstractOvarian cancer is a complex disease associated with multiple genetic and epigenetic alterations. The emergence of treatment resistance in most patients causes ovarian cancer to become incurable, and novel therapies remain necessary. We identified epigenetic regulator ATPase family AAA domain-containing 2 (ATAD2) is overexpressed in ovarian cancer and is associated with increased incidences of metastasis and recurrence. Genetic knockdown of ATAD2 or its pharmacological inhibition via ATAD2 inhibitor BAY-850 suppressed ovarian cancer growth and metastasis in both in vitro and in vivo models. Transcriptome-wide mRNA expression profiling of ovarian cancer cells treated with BAY-850 revealed that ATAD2 inhibition predominantly alters the expression of centromere regulatory genes, particularly centromere protein E (CENPE). In ovarian cancer cells, changes in CENPE expression following ATAD2 inhibition resulted in cell-cycle arrest and apoptosis induction, which led to the suppression of ovarian cancer growth. Pharmacological CENPE inhibition phenotypically recapitulated the cellular changes induced by ATAD2 inhibition, and combined pharmacological inhibition of both ATAD2 and CENPE inhibited ovarian cancer cell growth more potently than inhibition of either alone. Thus, our study identified ATAD2 as regulators of ovarian cancer growth and metastasis that can be targeted either alone or in combination with CENPE inhibitors for effective ovarian cancer therapy.
Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron
Authors: Bordoni Luca , Kristensen Anders M. , Sardella Donato , Kidmose Hanne , Pohl Layla , Krag Søren Rasmus Palmelund , Schiessl Ina Maria 
Published: July 2023

AbstractAcute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely understood. In this study, we aimed for dynamic tracking of tubule injury and remodeling to understand if focal injury upon AKI may spread over time. Here, we present a model of AKI, in which we rendered only half of the kidney ischemic. Using serial intravital 2-photon microscopy and genetic identification of cycling cells, we tracked dynamic tissue remodeling in post- and non-ischemic kidney regions simultaneously and over 3 weeks. Spatial and temporal analysis of cycling cells relative to initial necrotic cell death demonstrated pronounced injury propagation and expansion into non-necrotic tissue regions, which predicted tubule atrophy with epithelial VCAM1 expression. In summary, our longitudinal analyses of tubule injury, remodeling, and fate provide important insights into AKI pathology.
MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial and ciliary functions by controlling gene promoters
Authors: Wang Dongmei , Li Haimin , Chandel Navdeep S. , Dou Yali , Yi Rui 
Published: July 2023

AbstractHistone H4 lysine 16 acetylation (H4K16ac), governed by the histone acetyltransferase MOF, orchestrates gene expression regulation and chromatin interaction. However, the roles of MOF and H4K16ac in controlling cellular function and regulating mammalian tissue development remain unclear. Here we show that conditional deletion of Mof in the skin, but not Kansl1, causes severe defects in the self-renewal of basal epithelial progenitors, epidermal differentiation, and hair follicle growth, resulting in barrier defects and perinatal lethality. MOF-regulated genes are highly enriched for essential functions in the mitochondria and cilia. Genetic deletion of Uqcrq, an essential subunit for the electron transport chain (ETC) Complex III, in the skin, recapitulates the defects in epidermal differentiation and hair follicle growth observed in MOF knockout mouse. Together, this study reveals the requirement of MOF-mediated epigenetic mechanism for regulating mitochondrial and ciliary gene expression and underscores the important function of the MOF/ETC axis for mammalian skin development.
Attosecond delays between dissociative and non-dissociative ionization of polyatomic molecules
Authors: Gong Xiaochun , Plésiat Étienne , Palacios Alicia , Heck Saijoscha , Martín Fernando , Wörner Hans Jakob 
Published: July 2023

AbstractThe interplay between electronic and nuclear motions in molecules is a central concept in molecular science. To what extent it influences attosecond photoionization delays is an important, still unresolved question. Here, we apply attosecond electron-ion coincidence spectroscopy and advanced calculations that include both electronic and nuclear motions to study the photoionization dynamics of CH4and CD4molecules. These molecules are known to feature some of the fastest nuclear dynamics following photoionization. Remarkably, we find no measurable delay between the photoionization of CH4and CD4, neither experimentally nor theoretically. However, we measure and calculate delays of up to 20 as between the dissociative and non-dissociative photoionization of the highest-occupied molecular orbitals of both molecules. Experiment and theory are in quantitative agreement. These results show that, in the absence of resonances, even the fastest nuclear motion does not substantially influence photoionization delays, but identify a previously unknown signature of nuclear motion in dissociative-ionization channels. These findings have important consequences for the design and interpretation of attosecond chronoscopy in molecules, clusters, and liquids.
p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism
Authors: Acosta Jonuelle , Li Qinglan , Freeburg Nelson F. , Murali Nivitha , Indeglia Alexandra , Grothusen Grant P. , Cicchini Michelle , Mai Hung , Gladstein Amy C. , Adler Keren M. , Doerig Katherine R. , Li Jinyang , Ruiz-Torres Miguel , Manning Kimberly L. , Stanger Ben Z. , Busino Luca , Murphy Maureen , Wan Liling , Feldser David M. 
Published: July 2023

AbstractThe p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse model of SCLC in which endogenous p53 expression can be conditionally and temporally regulated, we show that SCLC tumors maintain a requirement for p53 inactivation. However, we identify tumor subtype heterogeneity between SCLC tumors such that p53 reactivation induces senescence in a subset of tumors, while in others, p53 induces necrosis. We pinpoint cyclophilins as critical determinants of a p53-induced transcriptional program that is specific to SCLC tumors and cell lines poised to undergo p53-mediated necrosis. Importantly, inhibition of cyclophilin isomerase activity, or genetic ablation of specific cyclophilin genes, suppresses p53-mediated necrosis by limiting p53 transcriptional output without impacting p53 chromatin binding. Our study demonstrates that intertumoral heterogeneity in SCLC influences the biological response to p53 restoration, describes a cyclophilin-dependent mechanism of p53-regulated cell death, and uncovers putative mechanisms for the treatment of this most-recalcitrant tumor type.