bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health literacy and associated factors among undergraduate health sciences students in western Nepal: a cross-sectional study
Authors: Gairhe Samikshya , Gyawali Bishal , Pahari Sandip , Jnawali Kalpana , Poudel Arati , Khatri Dhurba , Paneru Damaru Prasad 
Published: March 2023

AbstractDespite the importance of health literacy for health promotion, Nepalese undergraduate students are largely unaware of its importance. The present study assessed the health literacy levels of undergraduate health sciences students and explored various sociodemographic, clinical and health information-related factors associated with health literacy at Pokhara University in the Kaski district of western Nepal. A cross-sectional web-based observational study was conducted among 406 undergraduate students university students from five faculties at the School of Health and Allied Sciences affiliated with Pokhara University. Data on sociodemographic information, clinical characteristics and sources of health information were collected. Health literacy was assessed using the 44-item measure that captures the concept of health literacy across nine distinct domains. Associated factors were examined using a one-way analysis of variance followed by stepwise backward multiple linear regression analysis at the level of significance of 0.05. The mean score for the health literacy questionnaire was 3.13 ± 0.26. Outcomes of multivariable analyses demonstrated various factors associated with health literacy scores, including age (β = 0.10; p = 0.001), physical exercise (β = −0.13; p &lt; 0.001), monthly household income (β = 0.05; p = 0.029) and routine health checkup (β = −0.14; p &lt; 0.001). The study showed that there is a need to understand and address sociodemographic factors and clinical factors, including age, physical exercise, monthly household income and routine health checkups to improve health literacy levels among undergraduate students in western Nepal. More research, including longitudinal studies, is needed to better understand factors that influence health literacy among undergraduate students in Nepal.
Social network and health behaviors among Japanese older adults: a three-wave longitudinal study
Authors: Harada Kazuhiro , Masumoto Kouhei , Okada Shuichi 
Published: March 2023

SummaryIdentifying modifiable determinants of behavior is essential for developing effective strategies to promote health behaviors among older adults. Although social networks are potentially modifiable determinants of health behaviors, their longitudinal associations have not been established in previous studies. The present study examined whether a larger social network is associated with higher dietary variety, longer time spent exercising and shorter time spent viewing TV among older adults. This is a longitudinal study. The data of 908 Japanese older adults were obtained through a three-wave questionnaire survey (Wave 1, December 2017 to January 2018; Wave 2, after 1 year; Wave 3, after 3 years) and analyzed. In each wave of the survey, dietary variety (dietary variety score), exercise time (hours per day), TV viewing time (hours per day) and social network (family and friend subscales of the Japanese version of the abbreviated Lubben Social Network Scale) were measured. The present study used latent growth, cross-lagged and simultaneous effect models to investigate the longitudinal associations of family and friend social networks with dietary variety, exercise time and TV viewing time. However, these models did not show clear and robust associations. Whether social networks are determinants of health behaviors among older adults remains inconclusive.
Salud postpandemia: influencia supranacional y coordinación regulatoria
Authors: Benavides Reverditto Ximena 
Published: March 2023

Abstract
The dominant position of the U.S. Food and Drug Administration (FDA) as the most influential regulator in the world has been particularly salient during the COVID-19 pandemic, in the context of COVID-19 vaccines’ emergency use authorizations. In the context of adjustment toward a post-COVID-19 regulatory order of harmonization for medicines approval, this essay proposes a critical reflection about the justifications and political dynamics behind the FDA’s power and its impact in latinamerican countries’ regulatory systems, considering the already regulatory reliance on the FDA. In particular, this essay asks whether regulatory ‘agility’ and ‘coordination’ will benefit countries of the region in addressing the problems of scarcity and inequitable access to medicines that have become evident with the pandemic.
Heat- and Wave-Type Equations with Nonlocal Operators, I. Compact Lie Groups
Authors: de Moraes Wagner A A , Restrepo Joel E , Ruzhansky Michael 
Published: March 2023

Abstract
We prove existence and uniqueness and give the analytical solution of heat and wave type equations on a compact Lie group $G$ by using a nonlocal (in time) differential operator and a positive left invariant operator (maybe unbounded) acting on the group. For heat type equations, solutions are given in $L^q(G)$ for data in $L^p(G)$ with $1&lt;p\leqslant 2\leqslant q&lt;+\infty $. We also provide some asymptotic estimates (large-time behavior) for the solutions. Some examples are given. Also, for wave-type equations, we give the solution on some suitable Sobolev spaces over $L^2(G)$. We complement our results, by studying a multi-term heat-type equation as well.
The primary pharmacology of ceftazidime/avibactam: microbiology from clinical studies, and development of resistance during treatment
Authors: Nichols Wright W , Bradford Patricia A , Stone Gregory G 
Published: March 2023

AbstractAs one of a series of thematically linked reviews of the primary pharmacology of the β-lactam/β-lactamase inhibitor combination, ceftazidime/avibactam, this article reviews the microbiological findings in drug-exposed patients. Earlier articles in the series focused on basic in vitro and in vivo translational biology (J Antimicrob Chemother 2022; 77: 2321–40 and 2341–52) and the development and mechanisms of resistance in vitro (J Antimicrob Chemother 2023: Epub ahead of print. doi: 10.1093/jac/dkac449). In clinical trials of ceftazidime/avibactam, combined favourable microbiological responses for evaluable patients infected at baseline by susceptible Enterobacterales or Pseudomonas aeruginosa were 86.1% (851/988). The corresponding percent favourable among patients infected by ceftazidime/avibactam-resistant pathogens was 58.8% (10/17), noting that the majority (15/17) of the resistant examples were P. aeruginosa. Microbiological response rates to comparator treatments in the same clinical trials ranged between 64% and 95%, depending on the type of infection and the analysis population. Uncontrolled case studies over a wide range of patients infected by antibiotic multiresistant Gram-negative bacteria have demonstrated that ceftazidime/avibactam can elicit microbiological clearance of ceftazidime/avibactam-susceptible strains. In case studies where a matched cohort of patients had been treated with antibacterial agents other than ceftazidime/avibactam, microbiological outcomes were comparable between treatments, mostly being observationally more favourable for ceftazidime/avibactam (recognizing that numbers were too small for definitive superiority assessments). Development of resistance to ceftazidime/avibactam during therapy is reviewed. The phenomenon has been reported multiple times, mostly in difficult-to-treat patients infected by KPC-producing Enterobacterales. Molecular mechanisms, when determined, have frequently been observed previously in vitro, such as the ‘Ω-loop’ D179Y (Asp179Tyr) substitution found in KPC variant enzymes. In human volunteers exposed to therapeutic levels of ceftazidime/avibactam, faecal numbers of Escherichia coli, other enterobacteria, lactobacilli, bifidobacteria, clostridia and Bacteroides spp. decreased. Clostridioides difficile was detected in the faeces, but this was of uncertain significance, because no unexposed controls were studied.
Identification of a novel carbapenem-hydrolysing class D β-lactamase RAD-1 inRiemerella anatipestifer
Authors: Li Pei , Yang Zhishuang , Lei Ting , Dai Yujie , Zhou Yang , Zhu Dekang , Luo Hongyan 
Published: March 2023

AbstractObjectivesTo elucidate the role of a novel carbapenem-hydrolysing class D β-lactamase (RAD-1) from Riemerella anatipestifer.MethodsWe applied WGS and bioinformatic analysis to screen putative β-lactamase genes in R. anatipestifer SCVM0004. A putative class D β-lactamase gene was cloned into pET24a and transferred into Escherichia coli BL21 (DE3) for antibiotic susceptibility determination and protein purification. Meanwhile, the purified native protein was used to determine the enzymatic activities.ResultsA class D β-lactamase, RAD-1, was identified in the genome of R. anatipestifer SCVM0004. It was distinct from all characterized class D β-lactamases (≤42% amino acid sequence identity). Searching in GenBank showed that blaRAD-1 was widely disseminated among R. anatipestifer. Genomic environment analysis indicated that the chromosomal structures of blaRAD-1-located regions were relatively conserved. Expression of RAD-1 in E. coli results in elevated MICs for various β-lactam antibiotics, including penicillins, extended-spectrum cephalosporins, a monobactam and carbapenems. Moreover, kinetic analysis of purified RAD-1 revealed: (i) high-level activity against penicillins; (ii) highest affinity for carbapenems; (iii) moderate hydrolysis of extended-spectrum cephalosporins and a monobactam; and (iv) no activity for oxacillin and cefoxitin.ConclusionsThis study identified a novel chromosomally located class D carbapenemase RAD-1 (Bush–Jacoby functional group 2def) in R. anatipestifer SCVM0004. Moreover, bioinformatic analysis confirmed that the RAD-1 was widely prevalent and conserved in R. anatipestifer.
Fecal microbiota transplantation in patients with irritable bowel syndrome: an overview of current studies
Authors: Körner Elena , Lorentz Axel 
Published: March 2023

AbstractAs dysbiosis is a key factor associated with irritable bowel syndrome (IBS), modulation of the intestinal microbiota could improve IBS symptoms and quality of life. Fecal microbiota transplantation (FMT) could be one efficient way to restore bacterial composition in IBS patients. This review comprises 12 clinical trials published from 2017 to 2021. Inclusion criteria were the assessment of IBS symptoms using the IBS symptom severity score, quality of life measured by the lBS quality of life scale, and gut microbiota analysis. Improved symptoms were reported in all 12 studies, paralleling with an increased quality of life after FMT, but also partly after placebo treatment. The use of oral capsules showed that the placebo treatment can have similar or even stronger positive effects on IBS patients than FMT. Gastroscopic FMT appears to link modulation of the gut microbiome to significant symptom reduction in patients. The patient’s microbiota profile shifted toward their respective donors. Symptom worsening or decreased quality of life after FMT was not reported. The results show that FMT could be a therapeutic approach in IBS patients. Further research is needed to investigate whether FMT has a more beneficial effect on IBS patient than placebo treatment with the patient’s own stool, placebo capsules, or bowel cleansing. Moreover, optimal donor selection, frequency, dosage, and route of delivery still need to be defined.
Transcriptomic characterization of Lonrf1 at the single-cell level under pathophysiological conditions
Authors: Li Dan , Wang Teh-Wei , Aratani Sae , Omori Satotaka , Tamatani Maho , Johmura Yoshikazu , Nakanishi Makoto 
Published: March 2023

Abstract
The LONRF family of proteins consists of three isozymes, LONRF1–3, which harbors RING (really interesting new gene) domain and Lon substrate binding domain. We have recently identified LONRF2 as a protein quality control ubiquitin ligase that acts predominantly in neurons. LONRF2 selectively ubiquitylates misfolded or damaged proteins for degradation. LONRF2−/− mice exhibit late-onset neurological deficits. However, the physiological implications of other LONRF isozymes remain unclear. Here, we analysed Lonrf1 expression and transcriptomics at the single-cell level under normal and pathological conditions. We found that Lonrf1 was ubiquitously expressed in different tissues. Its expression in LSEC and Kupffer cells increased with age in the liver. Lonrf1high Kupffer cells showed activation of regulatory pathways of peptidase activity. In normal and NASH (nonalcoholic steatohepatitis) liver, Lonrf1high LSECs showed activation of NF-kB and p53 pathways and suppression of IFNa, IFNg and proteasome signalling independent of p16 expression. During wound healing, Lonrf1high/p16low fibroblasts showed activation of cell growth and suppression of TGFb and BMP (bone morphogenetic protein) signalling, whereas Lonrf1high/p16high fibroblasts showed activation of WNT (wingless and Int-1) signalling. These results suggest that although Lonrf1 does not seem to be associated with senescence induction and phenotypes, LONRF1 may play a key role in linking oxidative damage responses and tissue remodelling during wound healing in different modes in senescent and nonsenescent cells.
Food and feeding strategies of the deep-sea shrimpHeterocarpus woodmasoni, Alcock 1901 (Decapoda: Pandalidae) from southwestern India
Authors: Ambatt Padmanabhan Gayathri , Chakraborty Rekha Devi , Lakshman Sreesanth 
Published: March 2023

AbstractDiet composition and feeding strategies of deep-sea caridean shrimp Heterocarpus woodmasoniAlcock,1901 are described from gut contents of 4,116 specimens collected from the southwestern coast of India. Knowledge of the species diet plays a prime effect on its biological aspects and its role in the ecological energetics of the community. All the analyses were performed in accordance with ecological (season) and biological factors (sex, size, and gonadal stages). The species was found to prey on diversified components such as detritus, foraminiferans, other crustaceans, molluscs, echinoderms, and fishes in their declining order of preponderance. Multivariate analysis of variance showed a significant difference (P&lt;0.05) in the diet components according to the combination of sex along with season and gonadal stages. Values of the gastro-somatic index (GSI) showed a positive correlation with feeding activity, and its intensity. GSI, feeding intensity, and activity reached their peak values during the post-monsoon season. High vacuity index was recorded in almost all conditions, which is a highlighted feature of this species. These observations provide fundamental information on the feeding pattern of H. woodmasoni, which aims to develop suitable fishing strategies in the future.
Life After Conviction at the International Criminal Tribunal for the former Yugoslavia
Authors: Strupinskienė Lina 
Published: March 2023

Abstract
Of the 92 persons convicted at the International Criminal Tribunal for the former Yugoslavia (ICTY), 60 have already served their sentences and been released. Even though in post-conflict environments, the public behaviour of perpetrators can help counter (atrocity crime) denial, establish an authoritative version of the truth and contribute to sustainable reconciliation, we still know little about what happens once they return to their communities. This article is one of the first attempts to systematically map and understand what pathways the ICTY convicts take after release, and why. It finds that those who promote nationalist interpretations of the past and deny their responsibility and involvement in crimes are often hailed by receptive domestic audiences across the Western Balkans. They successfully use certain support networks, such as dominant political parties or military and war veterans’ organizations, to take back their place in public life. On the other hand, those convicts who have admitted their guilt and responsibility and do not promote a nationalist interpretation of the past often find themselves ostracized, living in poverty and seclusion.
Reforming Shareholder Claims in Investor-State Dispute Settlement
Authors: Arato Julian , Claussen Kathleen , Lee Jaemin , Zarra Giovanni 
Published: March 2023

Abstract
Investor-state dispute settlement (ISDS) stands alone in empowering shareholders to bring claims for shareholder reflective loss (SRL)—meaning claims over harms allegedly inflicted upon the company, but which somehow affect share value. National systems of corporate law and public international law regimes generally bar SRL claims for strong policy reasons bearing on the efficiency and fairness of the corporate form. However, ISDS tribunals allow shareholders broad and regular access to seek relief for reflective loss. The availability of SRL claims in ISDS ultimately harms States and investors alike, imposing surprise ex post costs on States and various corporate stakeholders (particularly creditors), and creating perverse incentives likely to raise the cost of doing business ex ante. The article sets out the harms caused by allowing ISDS claims for reflective loss, as well as the possible justifications for allowing such claims in this specific context. Concluding that any potential benefits of SRL can be realized through less invasive means, we then canvas a number of plausible reform options, with an eye to their trade-offs.
Parent Perspectives of School/Daycare Experiences in Young Children Newly Diagnosed With Diabetes
Authors: Stern Alexa , Duran Brenda , Streisand Randi , Wang Christine H , Tully Carrie , Clary Lauren , Gallagher Katherine , Cogen Fran , Karaviti Lefkothea , Monaghan Maureen , Hilliard Marisa E 
Published: March 2023

AbstractObjectiveA central part of family adjustment to a new diagnosis of type 1 diabetes (T1D) is integrating T1D management into the child’s school/daycare. This may be particularly challenging for young children who rely on adults for their diabetes management. This study aimed to describe parent experiences with school/daycare during the first 1.5 years following a young child’s T1D diagnosis.MethodsAs part of a randomized controlled trial of a behavioral intervention, 157 parents of young children with new-onset (&lt;2 months) T1D reported on their child’s school/daycare experience at baseline and at 9- and 15-month post-randomization. We used a mixed-methods design to describe and contextualize parents’ experiences with school/daycare. Qualitative data were collected via open-ended responses, and quantitative data were collected from a demographic/medical from.ResultsWhile most children were enrolled in school/daycare at all time points, over 50% of parents endorsed that T1D affected their child’s enrollment, rejection, or removal from school/daycare at 9 or 15 months. We generated five themes related to parents’ school/daycare experiences: Child factors, Parent factors, School/Daycare factors, Cooperation between Parents and Staff, and Socio-historical factors. Parents of younger children and those with lower subjective socioeconomic status were significantly more likely to endorse challenges with school/daycare enrollment.ConclusionsSchool/daycare settings present challenges for parents of young children with T1D. Changes may need to occur across contexts to support early childhood education, including advocacy resources for parents to navigate school policies, increased training for school staff, and healthcare team outreach initiatives to parents and schools.
Estimation of temperature-dependent growth profiles for the assessment of time of hatching in forensic entomology
Authors: Pigoli Davide , Ferraty Frédéric , Aston John A D , Mazumder Anjali , Richards Cameron , Hall Martin J R 
Published: March 2023

Abstract
Forensic entomology contributes important information to criminal investigations. This paper proposes a novel method to estimate the hatching time of fly larvae based on the temperature profile at the crime scene and on experimental data on larval development, where larvae are exposed to a constant temperature. We develop a dynamic model to estimate the growth curve under time-varying temperature profiles and the corresponding hatching time at the crime scene. Asymptotic properties are provided for the proposed estimators, and we explore their robustness via simulations. The proposed methodology is demonstrated on data from two criminal cases from the UK.
Supraclavicular metastasis from prostate cancer: unusual case and literature review
Authors: Ascio Noelani-Mei , Qureshi Abid , Banayan Elliot , Asarian Armand , Genato Romulo , Xiao Philip 
Published: March 2023

AbstractProstate cancer is the most common cancer among men, with the most common metastatic sites in bone, regional lymph nodes, liver and thorax. It is most commonly diagnosed in the early stages with clinical findings of enlarged prostate on digital rectal exam and positive prostate specific antigen. Distant metastases associated with prostate cancer commonly occur to bone. It is imperative to be cautious in assuming primary breast, lung or head and neck malignancy in patients presenting with lymphadenopathy in the upper aerodigestive pathways. Cervical lymphadenopathy due to prostate cancer is becoming more prevalent since previously reported. Here we present a case of prostate cancer recurrence found through metastasis to supraclavicular lymph nodes and we also highlight homeobox protein CDX2 as a potential clinico-pathological marker in metastatic prostate cancer.
Perforated mediastinal gastric volvulus: an uncommon complication of hiatal hernia
Authors: Schneider Mateus Henrique , Solis-Pazmino Paola , Maldonado Pedro , Hamaoui Mohamed 
Published: March 2023

AbstractA woman in her 50s was admitted to the emergency department with a 3-day history of abdominal pain, mainly in the right hypochondrium, radiating to the back, associated with postprandial vomiting and dysphagia. The abdominal ultrasound study found no abnormalities. Laboratory tests showed increased C-reactive protein levels, creatinine and high white blood cell count without a left shift. Abdominal computed tomography scan exhibited mediastinal herniation, twist and perforation of the gastric fundus associated with air-fluid levels in the lower mediastinum. The patient underwent diagnostic laparoscopy requiring laparotomy conversion due to hemodynamic instability related to the pneumoperitoneum. During the intensive care unit (ICU) stay, thoracoscopy with pulmonary decortication was performed to treat complicated pleural effusion. After ICU and standard infirmary bed recovery, the patient was discharged from the hospital. This report illustrates a case of perforated gastric volvulus as the cause of nonspecific abdominal pain.
Rare dual surgical pathology at emergency laparotomy: a case report of concurrent small bowel obstruction and appendicitis
Authors: Tully Dylan S , Balasooriya Janaka , Lim James 
Published: March 2023

AbstractDual surgical pathology at emergency laparotomy is an uncommon finding outside of trauma scenarios. There is a scarcity of case reports of concomitant small bowel obstruction and appendicitis at laparotomy, likely in part because of advancements in investigative tools, diagnostic processes and the ready availability of medical care, which is demonstrated by harrowing statistics from developing nations where these factors are lacking. However, despite these advancements, initial diagnosis of dual pathology can be difficult. We report a case of concurrent small bowel obstruction and occult appendicitis discovered at emergency laparotomy in a previously well female with a virgin abdomen.