bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic damage evaluation of lining across the main sliding surface reinforced with multi-anchor round piles under different seismic sequences
Authors: Pai Lifang , Wu Honggang 
Published: April 2023

Abstract
To study the dynamic damage effect of lining across the main-sliding surface reinforced with multi-anchor round piles under different seismic sequences, shaking table test is used for the first time to design two loading sequences of "foreshock-main shock" and "mainshock-aftershock". Based on acceleration, the seismic performance evaluation factor (SPEC) and seismic effect coefficient (Sec) of reinforced lining are proposed. Based on dynamic strain, a calculation method of shear force (Sf) and bending moment (Mb) of multi-anchor round piles is proposed, and the distribution characteristics are given. The evaluation index of reinforcement effect evaluation coefficient (REEC) of reinforced lining is put forward. The results show that the acceleration of the main-aftershock sequence to the multi-anchor round piles is greater than that of the foreshock-main shock sequence. The Sf of pile presents inverted "S" type distribution, while the Mb presents "S" type distribution. Compared with the unoptimized multi-anchor round piles, the seismic effect of Sec and REEC can reach 3.04%-18.96% and 120%-180% respectively. The seismic effect of anchor head optimization is related to seismic sequence, and it is more suitable for seismic structure design of foreshock-main shock sequence. It has great popularization value in tunnel-landslide engineering treatment in high intensity area.
High-efficient biosorbent of Pb2+ derived from the organic frameworks of Cladophora rupestris
Authors: Zhang Lu-sheng , Feng Xiao-yu , Li Ling-sheng , Sun Yu , Tao Xin-yi , Yin Qian , Li Xin-yue , Ma Shi-ying , Cao deju , Liu Zhao-wen 
Published: April 2023

Abstract
This study aims to investigate the Pb2+ adsorption performance of the organic frameworks derived from Cladophora rupestris (CROF). The characterizations of CROF and Pb2+ adsorption process was analysed using SEM-EDS, LPSA, BET, PHPZC, FTIR and XPS. The results was showed that CROF was porous structure, had both macroporous and microporous properties. The particle size is normally distributed with a median diameter of 36.8 µm. PHPZC of CROF was 7.02. The CROF adsorption isotherms and kinetics closely matched Langmuir model and Pseudo-second-order(PSO), respectively, the adsorption behaviors can be classified as monolayer chemical adsorption. The maximum adsorption capacity (Qm) was 15.02 mg/g and 97% of the Pb2+ was adsorbed onto the CROF within 20 min. And the adsorption was exothermic, spontaneous and minimised randomness. Additionally, the biosorbent has outstanding Pb2+adsorption capability due to pore filling, ion exchange, Pb-πinteraction, and surface complexation between nitrogen and oxygen functional groups(OFGs and NFGs). CROF is economical and environmentally friendly and it can be used as an adsorbent to take Pb2+ out from waterbodies.
Complications and Related Risk Factors of Transradial Access Cannulation for Hemodynamic Monitoring in General Surgery： A Prospective Observational Study
Authors: Hou Qin , Zhou Bin , He Juanjuan , Chen Xueying , Zuo Yunxia 
Published: April 2023

Abstract
Purpose To examine the short-term complications of arterial cannulation for intraoperative monitoring and their related risk factors.Methods We included adult inpatients (≥ 18 years old) who underwent an initial transradial access (TRA) cannulation and were scheduled for general surgery between April 8 and November 30, 2020. We used 20G arterial puncture needles for puncturing and manual compression for hemostasis. Demographic, clinical, surgical, anesthetic, and laboratory data were extracted from electronic medical records. Vascular, neurologic, and infectious complications of TRA cannulation were recorded and analyzed. Univarable and multivariable logistic regression analyses were used to identify risk factors related to TRA cannulation for intraoperative monitoring.Results Among 509 included patients, 174 developed TRA cannulation-related complications. Puncture site bleeding/hematoma and median nerve injury were observed in 158 (31.0%) and 16 (3.1%) patients, respectively. No patient developed cannula-related infections. Multivariable regression analysis revealed increased odds of puncture site bleeding/hematoma in women (odds ratio 4.49, 95% CI 2.73–7.36; P < 0.001) and patients who received intraoperative red blood cell (RBC) suspension transfusion ≥ 4U (odds ratio 5.26, 95% CI 1.41–19.57; P = 0.01). No risk factors for nerve injury were identified.Conclusion Bleeding/hematoma was a common complication of TRA cannulation for intraoperative hemodynamic monitoring during general surgery. Median nerve injury may be an underrecognized complication. Female sex and extensive intraoperative RBC transfusion are associated with an increased risk of bleeding/hematoma; however, the risk factors for nerve injury remain unclear.Trial registration The study protocol was registered at https://www.chictr.org.cn (ChiCTR1900025140).
The effect of risperidone on behavioral reactions and gene expression of pro and anti-inflammatory cytokines in neuropathic pain model induced by chronic constriction injury of the sciatic nerve in rat
Authors: Lari Mohammad Mehdi Haghighat , Banafshe Hamid Reza , Hosseini Elahe Seyed , Kashani Hamed Haddad 
Published: April 2023

Abstract
Background:
Neuropathic pain is caused by injury or disease that affects the somatosensory system. Management of patients with chronic neuropathic pain remains a challenge Multiple studies have reported the analgesic effects of serotonin receptor antagonists in different experimental pain models. This study aimed to investigate the effect of systemic administration of risperidone on the behavioral score of neuropathic pain in the chronic contraction (CCI) model in rats.
Methods:
Inducing neuropathic pain with the CCI model which causes heat hyperalgesia, heat & mechanical allodynia was performed on rats then in 2 phases risperidone effect was determined. in the acute phase, risperidone 1,2,4 mg was administered for 3 groups half an hour before behavioral tests on the 7th,14th, and 21st day after surgery, and in the chronic phase risperidone 1,2,4 mg was administered for 3 different groups from the 1st to 14th days after surgery than on 14th-day behavioral scores were performed. For gene expression analysis, samples are taken from spinal cord tissues in lumbar segments.
Results:
This study shows chronic administration of risperidone as an antipsychotic drug was effective on heat hyperalgesia & allodynia. However, only the max dosage (4mg) of risperidone showed meaningful improvement in increasing mechanical allodynia. however acute administering of risperidone didn’t show any meaningful changes in behavioral tests on neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. In addition, gene expression results showed an increase in IL-4 and IL-10 gene expression in the risperidone group compared to the sham group.
Conclusion:
This study suggests the helpful preventive effects of risperidone in developing and increasing neuropathic pain but it doesn’t have any instant effect.
A Study on the Mesoscale Eddies In the Northern Indian Ocean and the Concentration of Its Inner Chlorophyll-a
Authors: Zhao Sicong , Shen Zhichao , Shen Zhou , Zhu Guohao , Ji Fangzheng , Sun Jialong 
Published: April 2023

Abstract
This paper uses the observation data set of the interaction among the atmosphere, ocean, and organisms caused by the global mesoscale eddy and the data of chlorophyll-a in the tertiary sea surface (OC-CCI 5.0 version) to make month-on-month and year-on-year statistical analysis on the life cycle, movement trajectory and generation number of mesoscale eddies in the North Indian Ocean (5°N-30°N, 45°E-100°E) from 2009 to 2019. It also summarizes the spatiotemporal variation characteristics of chlorophyll concentration inside the mesoscale eddies in this sea area and makes a brief analysis accordingly. The analysis results show that the life cycle, spatial distribution, and frequency distribution of the number of cyclone and anticyclone vortices in the North Indian Ocean are relatively consistent, and they all move westward. The average lifespan of the cyclone vortex is 7.94 weeks, slightly longer than that of the anticyclone vortex, which is 7.87 weeks. The monthly average number of cyclone vortices is 9, more than the monthly average number of anticyclone vortices of 8. There are obvious seasonal differences. Cyclonic eddies will increase the sea surface Chl-a concentration, while anticyclonic eddies will reduce the sea surface Chl-a concentration. And the concentration distribution of Chl-a may be affected by the seasonality of mesoscale eddies.
Dual-frequency piezoelectric micromachined ultrasound transducer based on polarization switching in ferroelectric thin film
Authors: Lee Byung Chul , Park Jin Soo , Jung Soo Young , Kim Dong Hun , Park Jung Ho , Jang Ho Won , Kim Tae Geun , Baek Seung-Hyub 
Published: April 2023

Abstract
Dual-frequency ultrasound has advantages over conventional ultrasound, which operates at a specific frequency band, due to its additional frequency response. Moreover, a tunable frequency from a single transducer enables sonographers to achieve ultrasound images with a large detection area and high resolution. This facilitates the availability of more advanced techniques that require low- and high frequency ultrasound simultaneously such as harmonic imaging and image-guided therapy. In this article, we present a novel method for dual-frequency ultrasound generation from a ferroelectric piezoelectric micromachined ultrasound transducer (PMUT). Uniformly designed transducer arrays can be used for both deep low-resolution imaging and shallow high-resolution imaging. To switch the ultrasound frequency, the only requirement is to tune a DC bias for controlling the polarization state of the ferroelectric film. Flextensional vibration of the PMUT’s membrane strongly depends on the polarization state, producing low- and high-frequency ultrasound from a single excitation frequency. This strategy for dual-frequency ultrasound dispenses with the requirement for either multi-electrode configurations or hetero-designed elements, which are integrated into an array. Consequently, this technique significantly reduces the design complexity of transducer arrays and their associated driving circuits.
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-kB, NLRP3 inflammasome, and autophagy pathways.
Authors: Abdelaziz Rania R. , Awad Ahmed M. , Elshaer Sally L. , Gangaraju Rajashekhar , Nader Manar A. 
Published: April 2023

Abstract
Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic complications and the trigger of end-stage renal disease (ESRD), underscoring the concern of any therapeutic intervention directed at ameliorating the development and progression of DN. The current study explored the renoprotective impact of montelukast (Mon) against streptozotocin (STZ)-induced DN in rats compared to a standard anti-hyperglycemic insulin (Ins) treatment. Diabetes was induced by a single dose of STZ (55 mg/kg). Diabetic rats were treated with Mon (10 and 20 mg/kg, oral gavage) for eight weeks. Mon administration for 8 weeks after induction of diabetes conferred significant dose-dependent renoprotection, independent of blood glucose levels (unlike Ins), as evidenced by the improvement in serum creatinine, and blood urea nitrogen (BUN), and ameliorated STZ-induced renal necrotic, inflammatory alterations, and renal fibrosis. Additionally, Mon treatment in diabetic rats significantly restored redox hemostasis as evidenced by malondialdehyde (MDA) and total antioxidant capacity (TAC) levels; significantly reduced the renal expression of high mobility group box (HMGB) 1, toll-like receptor (TLR) 4, nuclear factor kappa B (NF-κB) (in the nucleus), NOD-like receptor family pyrin domain containing (NLRP) 3, and interleukin (IL) -1β. Moreover, Mon administration ameliorated the dysregulation in autophagy as evidenced by p62 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-II levels. In conclusion, the renoprotective effect of Mon is potentially associated with its modulatory effect on inflammatory cytokines, antioxidant properties and autophagy.
Hemagglutinin genetic characteristics of the influenza B virus Victoria lineage in Fujian Province from 2015 to 2022，China
Authors: LIN Qi , YAN Yuqing , ZHANG Yanhua , WU Jingjing , Chen Hongbin 
Published: April 2023

Abstract
Objective This study analyzed the molecular characteristics of hemagglutinin(HA) of the influenza B virus (IBV) Victoria lineage in Fujian Province from 2015 to 2022.Methods Fujian flu surveillence data during 2015.1.1-2022.3.31 were collected through China’s Disease Prevention and Control Information System and counted.The strains were obtained from canine kidney passaged cells or chicken embryo culture isolates of influenza-like cases from the 2015–2022 Influenza Network Surveillance System.The virus nucleic acid was extracted, and the HA gene fragment was amplified by RT-PCR and sequenced .MEGA5.0, Net NGlyc 1.0 Server software to analyse genetic characteristics.Results From 2015 to 2022, the HA gene of the influenza B virus Victoria lineage in Fujian Province had three nucleotide lengths, 1758 bp、1752 bp and 1749 bp respectively.The HA gene differential loci are mainly involved in the antigenic determinant clusters 120-loop, 150-loop, 160-loop, 190-helix and several receptor binding sites(RBS).145, 166 and 197 glycosylation sites are more diverse relative to other glycosylation sites.Conclusion The variation of the HA gene of influenza B virus Victoria lineage in Fujian Province from 2015 to 2022 is diversifying and the number of variant loci is increasing year by year, and research should continue to be strengthened to provide basic data for the prevention and control of the epidemic in Fujian Province.
Knowledge, Experiences, and Attitude towards Tuberculosis Disease among Clinical and Pre-clinical Medical Students in the West Bank, Palestine: a cross-sectional study
Authors: Dukmak Osama N. , Tos Salem M. , Alawi Ranin F. F. , Farhat Walaa K. Y. , Asad Diya M. , Elqadi Muawiyah 
Published: April 2023

Abstract
Background Tuberculosis (TB) is one of the most common causes of mortality worldwide. The global tuberculosis report in 2020 states that TB remains a major public health problem. Even though the incidence of TB in Palestine has fluctuated recently, medical students' training and education about TB are necessary to perform effective clinical practice and to control the disease appropriately in the future. This study aims to assess the experiences, knowledge, and awareness toward TB among medical students in the West Bank, Palestine, and to compare the level of knowledge among clinical and pre-clinical medical students.Methods A cross-sectional study was conducted on medical students at two Palestinian medical schools. The students were enrolled voluntarily and were administered a well-structured electronic questionnaire analyzed using SPSS version 26.0 after ethical approval was given.Results A total of 383 students participated in the study and were divided into two groups, pre-clinical 252 (65.8%) and clinical 131 (34.2%). Most (89.1%) had never seen TB in clinical practice, and two-thirds (66.8%) considered themselves ignorant about TB. Although BCG vaccination is mandatory in Palestine, only 36.6% of medical students believed that they were vaccinated with BCG. Only 4.4% and 20.6% of clinical students had performed a Mantoux test and observed at least one X-ray of a TB case, respectively. The year of study was associated with students’ knowledge of TB (P > 0.05). 76.3% of clinical and 25.6% of preclinical sd that a positive Mantoux test doesn’t mean a definite TB infection and about 77.1% of clinical and 31.7% of preclinical perceived that Penicillin G is not useful for TB treatment. Medical students had poor knowledge about the prophylactic treatment of TB (9.9%) and the prevalence of TB disease in Palestine (12.5%).Conclusion Clinical students significantly had better knowledge than pre-clinical. The study showed limited experience, awareness, and knowledge regarding TB among medical students. The findings suggest that more effort is needed to improve medical students' knowledge regarding TB disease.
Adequacy of an automatic tool to select and stratify chronic complex patients with multiple unplanned visits to the emergency department
Authors: Abadías María José , Giménez Emmanuel , San-José Antonio , Losada Marta , Acezat Jordi , Ibañez Jordi , Marte Luis , Berrecheguren Miriam , Mendez Ana , Aguayo Marta , Ramos Rosa 
Published: April 2023

Abstract
Background: Unplanned emergency department visits are an ongoing challenge, since the patients are increasingly ageing, chronic, complex, frail and multimorbid. The aim is to demonstrate the feasibility of establishing a proactive intervention to detect and distribute complex, chronic, unplanned multiple emergency department patients, tailored to the patient's needs.
Methods: Prospective study to evaluate the intervention, which is divided into the following drivers: automated pre-selection sent lists, a specific experienced multiple frequent case-manager nurse, and a 3-level territorial derivation consensus protocol. Chronic complex patients presenting two or more times in the last six months to a tertiary hospital emergency department for COPD or HF. Analysis of the percentage of patients well selected by the three drivers, and their corresponding characterisation by the three levels of care to which they are referred: primary, intermediate and specialist care. Number of visits six months before and after referral.
Results: 368 patients were selected; the 85% were well selected. The patients' age, frailty, home care percentage, Barthel index and cognition are progressively consistent with the three levels of care of referral according to previously defined and consensus criteria. The intervention achieves lowering participant visits: 3.1 before (SD = 2.42) versus 1.6 after (p < 0.001).
Conclusions: An automated selection, plus a territorial protocol consensus of circuits and clinical profiles, together with the autonomous assessment of a multiple case-managing nurse, achieves in a proactive and simple manner, a better and adapted distribution of patients in coherent care levels institutions, regarding their socio-health needs.
Concordance between Virtual Physician advice and subsequent health service utilization for callers to a nurse-managed provincial health information telephone service: a time-to-event analysis
Authors: Duncan Ross , Stewart Kurtis , Scheuermeyer Frank X. , Abu-Laban Riyad B. , Ho Kendall , Lavallee Danielle , Christenson Jim , Wood Nancy , Bryan Stirling , Hedden Lindsay 
Published: April 2023

Abstract
Background: British Columbia 8-1-1 callers who are advised by a nurse to seek urgent medical care can be referred to virtual physicians (VPs) for supplemental assessment and advice. Prior research indicates callers’ subsequent health service use may diverge from VP advice. We sought to 1) estimate concordance between VP advice and subsequent health service use, and 2) identify factors associated with concordance to understand potential drivers of discordant cases.Methods: We linked relevant provincial administrative databases to obtain inpatient, outpatient, and emergency service use by callers. We developed operational definitions of concordance collaboratively with researcher, patient, VP, and management perspectives. We used Kaplan-Meier curves to describe health service use post-VP consultation and Cox regression to estimate the association of caller factors (rurality, demography, attachment to primary care) and call factors (reason, triage level, time of day) with concordance as hazard ratios.Results: We analyzed 17,188 calls from November 16, 2020 to April 30, 2021. Callers advised to attend an emergency department (ED) immediately were the most concordant (73%) while concordance was lowest for those advised to seek Family Physician (FP) care either immediately (41%) or within 7 days (47%). Callers unattached to FPs were less likely to schedule an FP visit (hazard ratio = 0.76 [95%CI: 0.68–0.85]). Rural callers were less likely to attend an ED within 48 hours when advised to go immediately (0.53 [95%CI:0.46–0.61]) compared to urban callers. Rural callers advised to see an FP, either immediately (1.28 [95%CI:1.01–1.62]) or within 7 days (1.23 [95%CI: 1.11–1.37]), were more likely to do so than urban callers.Interpretation: Concordance between VP advice and subsequent caller health service use varies substantially by category of advice and caller rurality. Concordance with advice to “Go to ED” is high overall but to access primary care is below 50%, suggesting potential issues with timely access to FP care. Future research from a patient/caller centered perspective may reveal additional barriers and facilitators to concordance.
Dysregulated long non coding RNA as biomarkers for diagnosis of Mesothelioma: A Systematic Review
Authors: Elkahwagy Dina M. , Kiriacos Caroline Joseph , Mansour Manar 
Published: April 2023

AbstractBackground:Malignant Mesothelioma is a rare and fatal cancer caused by uncontrolled growth and proliferation of pleural mesothelial cells and it is frequently diagnosed late. Furthermore, diagnosis can be difficult, which provides incentive for the investigation of new methods of diagnosis. Biomarkers are biological indicators of a biological state or disease. lncRNA have been found to be linked to the progression of mesothelioma. LncRNAs were discovered to be expressed differently across tissues and conditions, which suggests potential as biomarkers.Aim:we discuss the potential in using lncRNA as biomarkers in Mesothelioma, emphasizing on specific lncRNA that have already been explored and to clarify their diagnostic value. In order to narrow down all lncRNA markers investigated for mesothelioma, we conducted a systematic review of the literature on the subject.Methods:Searches were conducted through four databases (Pubmed, JStor, Mdpi and Sciencedirect) for articles in time frame between 2010 and 2022. The search criteria based on the keywords: “Mesothelioma”, “lncRNA” or “Long non coding RNA”. The study was evaluated by 2 researches independently. Screening of 1141 articles, only 3 articles were included for fulfilling the criteria. Quality Assessment was carried using Diagnostic Accuracy Studies (QUADAS)-2Results:Three studies analyzed and confirmed the expression and diagnostic value of 4 lncRNAs (GAS5, lncRNA‐RP1‐86D1.3, SNHG8, POT1-AS1) by RT-qPCR in 96 patients of various ethnic backgrounds and gender groups.Conclusion:The present studies hold promise for LncRNAs as novel diagnostic markers for pleural mesothelioma. However, larger sample size and more standardized protocols are required for validation.