bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-parameter imaging by finite difference frequency domain full waveform inversion of GPR data: A guide for sedimentary architecture modeling
Authors: Layek Mrinal Kanti , Sengupta Probal 
Published: June 2023

Abstract

The need for reconstruction of the distribution of physical properties like dielectric permittivity and electrical conductivity of shallow subsurface sedimentary architecture leads to the development of an optimum strategy of GPR data inversion. In this paper, we present finite difference frequency domain (FDFD) full waveform inversion (FWI) method to get high-resolution subsurface model using GPR data. FWI is an optimization technique which involves in search of the minima between recorded and predicted data. The inversion process includes the quasi-Newton method and simultaneous frequency sampling strategy of irregular sampling. The Hessian term in quasi-Newton algorithm is approximated using preconditioned-LBFGS consideration and the search directions are also optimized after following the Wolfe conditions. At the end of each iteration during inversion, permittivity and conductivity models were updated and became ready to be the initial model for the next iteration. The goals of the study were to establish a suitable guideline for sedimentary-GPR data inversion and to test the effectiveness of newly proposed grid strategy during FWI. In this paper, a comparative study between existing and newly proposed methods are presented with aid of some numerical experiments performed using our own MATLAB programming. Numerical tests conducted on a benchmark from previously published article, established the fact that new grid formulation produces a faster converging rate and required less computation time. This method is very much effective for the realistic sedimentary model of the lossy medium. The proposed method is also applicable for modeling of the acoustic wave with some necessary modifications.
Intranasal Immunization of Mice with a Chimeric Antigen of Cholera Toxin B and Salmonella Typhi outer membrane protein T2544 elicits protective antibodies and T cell response at the intestinal mucosa
Authors: Chakraborty Suparna , Dutta Pujarini , Pal Ananda , Chakraborty Swarnali , Banik George , Halder Prolay , Gope Animesh , Miyoshi Shin-ichi , Das Santasabuj 
Published: June 2023

Abstract
Development of safe, highly effective and affordable enteric fever vaccines is a global health priority. Live, oral typhoid vaccines induce strong mucosal immunity and long-term protection, but safety remains a concern. In contrast, efficacy wears off rapidly for injectable, polysaccharide-based vaccines, which elicit poor mucosal response. We previously reported Salmonella Typhi outer membrane protein, T2544 as a potential candidate for bivalent (S. typhi and S. Paratyphi A) vaccine development. Here, we show that intranasal immunization with a subunit vaccine (chimera of T2544 and cholera toxin B subunit) induced strong systemic and intestinal mucosal immunity and protection from S. Typhi challenge in a mouse model. CTB-T2544 augmented gut-homing receptor expression on lymphocytes that produced Th1 and Th17 cytokines, secretory IgA in stool that inhibited bacterial motility and epithelial attachment, antibody recall response and affinity maturation with increased number of follicular helper T cells and CD4 + central and effector memory cells.
The association between Selenium and Epithelial Ovarian Cancer (EOC) among women; A protocol of a systematic review and meta-analysis
Authors: Perera K.C.M. , Perera W.N.D. , Abeysena H. T. C. S. 
Published: June 2023

Abstract
Introduction: Selenium (Se) may have a protective effect against some selected cancers. Ovarian cancer
is ranked as one of the major killers of all gynecological malignancies worldwide. The objective of this study
is to find the relationship between selenium intake and Epithelial Ovarian Cancer risk in women who have
not had an oophorectomy.
Methods: A comprehensive electronic search was carried out according to the prepared strategy from
the starting date of the PubMed/Medline, EMBASE, Scopus, Proquest, and Web of Science databases up to
30th of September 2022 without limitations related to language and publication status. Studies were screened by COVIDENCE. Cohort studies, case-control studies, cross-sectional analytical studies, ecological studies, and randomized control studies were included, and descriptive studies were excluded from the systematic review. The exposure of interest is high selenium intake from either food sources or supplements and also high measures of selenium in blood, toenails, or other biological samples, and high measures of serum selenoproteins. Data extraction will be done. New Castle Ottawa Scale will be used to assess the bias of observational studies. The findings will be synthesized first via a narrative description. If data permits results will be displayed via forest plots. All analyses will be conducted using STATA-17.
Discussion: Ovarian cancer is the most fatal gynecological malignancy among women. Due to the lack of recommended screening tools, the identification of modifiable effective risk factors and preventive tools are essential to reduce ovarian cancer burden. Selenium is a powerful antioxidant, therefore it prevents cell damage. It was proven in some studies that selenium protects against the development of some selected cancers. Therefore it is envisaged to find whether there is an inverse relationship between selenium and ovarian cancer for future preventive strategies.
Systematic review registration: Registered in the International Prospective Register of Systematic Reviews (PROSPERO)- CRD42022356472
FENOMENOLOGI AGAMA: PENDEKATAN FENOMENOLOGI UNTUK MEMAHAMI AGAMA
Authors: Ahimsa-Putra Heddy Shri 
Published: June 2023

In this article the author explains what is called ‘phenomeno­logical approach’ in the study of religion. Starting from Husserl’s philosophy of phenomenology, the author tracing its influences in social science through one of Husserl’s students, Alfred Schutz. Based on Husserl’s ideas developed by Schutz, the author presents his views how those ideas can be applied in the study of religion, and how religion can be defined phenomeno­logically. The author further explains some methodo­logical ethical implications of doing phenomeno­logical research on religion.***Dalam tulisan ini penulis menjelaskan apa yang disebut ‘pen­dekatan feno­menologi’ dalam kajian agama. Berangkat dari filsafat fenomeno­logi Husserl, penulis melacak pe­ngaruhnya pada ilmu sosial melalui salah seorang murid Husserl, Alfred Schultz. Berdasarkan ide Husserl yang di­kembangkan oleh Schultz, penulis menyajikan pan­dang­an­nya bagaimana ide-ide itu dapat diterapkan dalam kajian agama, dan bagaimana agama dapat didefinisikan secara fenomenologis. Penulis selanjutnya menjelaskan beberapa impli­kasi etis metodologis jika me­lakukan kajian fenomeno­logis terhadap agama.
Statistical blending of global-gridded climatological products: an approach to inverse hydrological model
Authors: Mousavi Rahimeh , Nasseri Mohsen , Abbasi Saeed 
Published: June 2023

Abstract
The growing use of global-scale environmental products in hydro-climatic modeling has increased the variety of their applications and the complications of their uncertainties and evaluations. Researchers have recently turned to statistical blending of these products to achieve optimal modeling. The proposed statistical blending in this study includes five large-scale and satellite precipitation (CHIRPS, ERA5-Land of ECMWF, GPM (IMERG), TRMM, and Terra) and evapotranspiration (GLEAM, SSEBop, MODIS, Terra, and ERA) products committed in three modeling scenarios. The blending procedures are organized using a conceptual water balance model to achieve the best precipitation and evapotranspiration results for the conceptual production of streamflow using hydrological inverse modeling. Based on the results, the proposed blending procedures of precipitation and evapotranspiration improved the performance of the model using different statistical metrics. In addition, the results show the conformity of the pattern and behavior of the blended precipitation calculated using the moving least square method in the study area. This happened by changing the estimation based on in situ values, particularly in cold months considering the orographic/snow effects. The combining method provides a good fusion procedure to improve the realistic estimation of precipitation and evapotranspiration in ungagged watersheds as well.
Using a compact unit for nitrification and denitrification processes followed by activated carbon filtration to remove total nitrogen from ammonium-contaminated groundwater
Authors: Ayoub Mohamed 
Published: June 2023

Abstract

The current study aims to evaluate the removal of ammonium-nitrogen (NH4+-N), generated nitrite (NH2−-N), and nitrate (NH3−-N) from groundwater using a compact unit for nitrification and denitrification processes that consist of a dripping nitrification reactor followed by a denitrification biofilter filled with treated cotton. Moreover, activated carbon filtration was applied as a post-treatment technique to remove the released total organic carbon (TOC) after the denitrification biofilter. The raw groundwater had an average NH4+-N concentration of 29.8 mg/L. To complete the analytical measurements, samples were taken from the compact unit's inlet, outlet, and sampling points for nitrification and denitrification, as well as the activated carbon filter. The obtained results indicated that the nitrification efficiency reached 98.81%, while the denitrification efficiency reached 95.98%. Moreover, the removal rate of total nitrogen ranged between 122.5 and 147 mg/d. On the other hand, the denitrification process utilizing cotton media resulted in a considerable increase in the outlet TOC concentrations, which ranged from 52.1 to 74.2 mg/L. The activated carbon filtration was applied to vanish the released TOC from the denitrification process after 10 days of operation.
Identifying 2PHDO as a SOCE inhibitor from Chinese herbal extracts
Authors: Wang Youjun , Liu Jindou , Deng Hao , Li Yaxin , Du Yangchun , Wang Liuqing , Wang Yuqing , Liu Jin , Xi Chao , Gao Ping , Zhou Yandong , Han Ling , Gill Donald L. , Lu Chuanjian 
Published: June 2023

Background:
STIM- and Orai-mediated store operated calcium entry (SOCE) is a ubiquitous Ca2+ signaling process, crucial for the proper function of immune, muscle and neuronal systems. To treat SOCE-related disorder or diseases of these systems, and to mechanistically dissect activation and function of SOCE, specific SOCE inhibitors are needed. However, strategies for developing new SOCE modifiers are still limited.

Methodology:
In this study, we identified a novel SOCE inhibitor named 2PHDO from a small pool of Chinese herbal extracts used for treating psoriasis. It could block SOCE and SOCE-mediated NFAT translocation in multiple types of cells with a half inhibitory concentration around 1 µM. At this concentration, 2PHDO was specific for SOCE. Mechanistically, 2PHDO didn’t affect the activation of STIM1 or its physical coupling with Orai1. Rather, 2PHDO inhibited SOCE via its actions on Orai1.

Results:
2PHDO may serve as a good template for developing new medicines aiming to treat SOCE related diseases.

Conclusion:
Overall, we proved the feasibility of screening and identification of novel SOCE inhibitors from active monomers of Chinese herbal medicine.
Navigating Molecular Pathways: An Update on Drugs in Colorectal
Cancer Treatment
Authors: Maurya Neha Shree , Mani Ashutosh 
Published: June 2023

Abstract:
Colorectal cancer (CRC) is a multifaceted and heterogeneous ailment that affects the
colon or rectum of the digestive system. It is the second most commonly occurring form of cancer
and ranks third in terms of mortality rate. The progression of CRC does not occur due to a single
mutational event; rather, it is the result of the sequential and cumulative accumulation of mutations
in key driver genes of signaling pathways. The most significant signaling pathways, which have
oncogenic potential due to their deregulation, include Wnt/β-catenin, Notch, TGF-β,
EGFR/MAPK, and PI3K/AKT pathways. Numerous drug target therapies have been developed to
treat CRC using small molecule inhibitors, antibodies, or peptides. Although drug-targeted therapy
is effective in most cases, the development of resistance mechanisms in CRC has raised questions
about their efficacy. To overcome this issue, a novel approach to drug repurposing has come to
light, which utilizes already FDA-approved drugs to treat CRC. This approach has shown some
promising experimental results, making it a crucial avenue of research in the treatment of CRC.
Recent Advances in Synthesis and Applications of Organic Ionic Saltsbased
Sensor Arrays
Authors: Kaur Pawanpreet , Parmar Anupama , Chopra Harish Kumar 
Published: June 2023

Abstract:
Sensor arrays contain a group of sensors, improve observations with new dimensions, provide
better estimations, and additional parameters in comparison to the individual selective sensor. The
array-based sensing technique provides good performance to respond to various gaseous or liquid analytes.
Room temperature ionic liquids (RTILs) (melting point <25oC) and Group of uniform materials
based on organic salts (GUMBOS) (melting point =25-250oC) are organic ionic salts, composed of an
oppositely charged pair of bulky organic cations and bulky organic/inorganic anion and shows interesting
tunable physicochemical properties. In this review article, we will discuss the sensing performance
of ILs- and GUMBOS-based sensor arrays. ILs-based sensor arrays have been used in electrochemical
gas sensing, solvent discrimination, colorimetric gas sensing, sensing of organic compounds, optoelectronic
sensing of vapors and solutions, and vapour sensing through IL/QCM systems. GUMBOS-based
sensor arrays have been employed in vapour sensing through the GUMBOS/QCM method, detection,
and discrimination of proteins.
Prenatal Supplementation of Docosahexaenoic Acid for the Management
of Preterm Births: Clinical Information for Practice
Authors: Thakur Shubham , Sharma Ritika , Jain Subheet Kumar 
Published: June 2023

Abstract:
Unhealthy pregnancy and the resultant abnormalities in newborns exhibit a significant drawback. Each year, an estimated 15 million babies are born prematurely, accounting for the ma-jority of deaths among children under the age of 5. India accounts for about a quarter of all preterm birth (PTB) incidences, with few therapeutic options available. However, research shows that con-suming more marine foods (rich in omega-3 fatty acids (Ω-3), particularly Docosahexaenoic acid (DHA), helps to maintain a healthy pregnancy and can manage or prevent the onset of PTB and its accompanying difficulties. Present circumstances raise concerns about the use of DHA as a medica-tion due to a lack of evidence on the dosage requirements, safety profile, molecular route, and commercially accessible strength for their therapeutic response. Several clinical experiments have been done over the last decade; however, the mixed outcomes have resulted in discrepancies. Most scientific organizations suggest a daily DHA consumption of 250-300 mg. However, this may differ from person to person. As a result, before prescribing a dosage, one should check the DHA concen-trations in the individual's blood and then propose a dose that will benefit both the mother and the unborn. Thus, the review focuses on the favourable benefits of Ω-3, particularly DHA during preg-nancy and postpartum, therapeutic dose recommendations, safety considerations, particularly during pregnancy, and the mechanistic pathway that might prevent or reduce the frequency of PTB acci-dents.
Philadelphia Chromosome Positive Chronic Myelogenous Leukemia Blastic
Crisis in a Patient with Unusual Primary Myelofibrosis Characteristics; A
Case Report
Authors: Razmara Lak Elahe , Sharifzadeh Sedigheh , Ramzi Mani , Mokhtari Maral , Asadpouri Reza , Abedi Elham , Tamaddon Gholamhossein 
Published: June 2023

Introduction:
Myeloproliferative neoplasms (MPNs) are divided into BCR-ABL positive
Chronic myeloid leukemia (CML) and BCR-ABL negative MPNs including Polycythemia
vera (PV), Essential Thrombocythemia (ET) and Primary myelofibrosis (PMF). Evaluation of the
Philadelphia chromosome in MPNs is a diagnostic requirement for classic CML.

Case Report:
In 2020, a 37-year-old woman with negative cytogenetic testing for Janus kinase2
(JAK2), Calreticulin (CALR), myeloproliferative leukemia virus oncogene (MPL), and positive
for BCR-ABL1 mutation with reticular fibrosis in bone marrow was diagnosed as CML. Some
years ago, the patient had been diagnosed with PMF with evidence of histiocytic necrotizing lymphadenitis
or Kikuchi-Fujimoto disease (KFD). The BCR-ABL fusion gene was initially evaluated
which was negative. Then, Cutaneous squamous cell carcinoma (cSCC) was confirmed by Dermatopathologist
with palpable splenomegaly and high white blood cell (WBC) count with basophilia.
Finally, BCR-ABL was detected positive by the fluorescence in situ hybridization (FISH)
and quantitative real-time polymerase chain reaction (qRT-PCR). In fact, the co-occurrence of
PMF with CML was identified.

Conclusion:
This case study highlighted the importance of some cytogenetic methods in the detection
and classification of MPNs. It is recommended that physicians pay more attention to it and be
aware of the planning treatment.
Associations Between Personality Traits and Energy Balance Behaviors in Emerging Adulthood: Cross-Sectional Study
Authors: Champion Katrina E , Chapman Cath , Sunderland Matthew , Slade Tim , Barrett Emma , Kelly Erin , Stapinski Lexine , Gardner Lauren A , Teesson Maree , Newton Nicola C 
Published: June 2023

Background
Internalizing and externalizing personality traits are robust risk factors for substance use and mental health, and personality-targeted interventions are effective in preventing substance use and mental health problems in youth. However, there is limited evidence for how personality relates to other lifestyle risk factors, such as energy balance–related behaviors, and how this might inform prevention efforts.

Objective
This study aimed to examine concurrent cross-sectional associations between personality traits (ie, hopelessness, anxiety sensitivity, impulsivity, and sensation seeking) and sleep, diet, physical activity (PA), and sedentary behaviors (SB), 4 of the leading risk factors for chronic disease, among emerging adults.

Methods
Data were drawn from a cohort of young Australians who completed a web-based, self-report survey in 2019 during early adulthood. A series of Poisson and logistic regressions were conducted to examine the concurrent associations between the risk behaviors (sleep, diet, PA, and sitting and screen time) and personality traits (hopelessness, anxiety sensitivity, impulsivity, and sensation seeking) among emerging adults in Australia.

Results
A total of 978 participants (mean age 20.4, SD 0.5 years) completed the web-based survey. The results indicated that higher scores on hopelessness were associated with a greater daily screen (risk ratio [RR] 1.12, 95% CI 1.10-1.15) and sitting time (RR 1.05, 95% CI 1.0-1.08). Similarly, higher scores on anxiety sensitivity were associated with a greater screen (RR 1.04, 95% CI 1.02-1.07) and sitting time (RR 1.04, 95% CI 1.02-1.07). Higher impulsivity was associated with greater PA (RR 1.14, 95% CI 1.08-1.21) and screen time (RR 1.06, 95% CI 1.03-1.08). Finally, higher scores on sensation seeking were associated with greater PA (RR 1.08, 95% CI 1.02-1.14) and lower screen time (RR 0.96, 95% CI 0.94-0.99).

Conclusions
The results suggest that personality should be considered when designing preventive interventions for lifestyle risk behaviors, particularly in relation to SB, such as sitting and screen time.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12612000026820; https://tinyurl.com/ykwcxspr
Reliability of Medical Information Provided by ChatGPT: Assessment Against Clinical Guidelines and Patient Information Quality Instrument
Authors: Walker Harriet Louise , Ghani Shahi , Kuemmerli Christoph , Nebiker Christian Andreas , Müller Beat Peter , Raptis Dimitri Aristotle , Staubli Sebastian Manuel 
Published: June 2023

Background
ChatGPT-4 is the latest release of a novel artificial intelligence (AI) chatbot able to answer freely formulated and complex questions. In the near future, ChatGPT could become the new standard for health care professionals and patients to access medical information. However, little is known about the quality of medical information provided by the AI.

Objective
We aimed to assess the reliability of medical information provided by ChatGPT.

Methods
Medical information provided by ChatGPT-4 on the 5 hepato-pancreatico-biliary (HPB) conditions with the highest global disease burden was measured with the Ensuring Quality Information for Patients (EQIP) tool. The EQIP tool is used to measure the quality of internet-available information and consists of 36 items that are divided into 3 subsections. In addition, 5 guideline recommendations per analyzed condition were rephrased as questions and input to ChatGPT, and agreement between the guidelines and the AI answer was measured by 2 authors independently. All queries were repeated 3 times to measure the internal consistency of ChatGPT.

Results
Five conditions were identified (gallstone disease, pancreatitis, liver cirrhosis, pancreatic cancer, and hepatocellular carcinoma). The median EQIP score across all conditions was 16 (IQR 14.5-18) for the total of 36 items. Divided by subsection, median scores for content, identification, and structure data were 10 (IQR 9.5-12.5), 1 (IQR 1-1), and 4 (IQR 4-5), respectively. Agreement between guideline recommendations and answers provided by ChatGPT was 60% (15/25). Interrater agreement as measured by the Fleiss κ was 0.78 (P<.001), indicating substantial agreement. Internal consistency of the answers provided by ChatGPT was 100%.

Conclusions
ChatGPT provides medical information of comparable quality to available static internet information. Although currently of limited quality, large language models could become the future standard for patients and health care professionals to gather medical information.
Socio-Juridical Analysis on Polygamy Requirements in the Compilation of Islamic Law (KHI)
Authors: Widiani Ah. Kholish Hayatuddin Desti 
Published: June 2023

Abstract: Socio-Juridical Analysis on Polygamy Requirements in the Compilation of Islamic Law (KHI).This study is aimed at seeing the relevance of the requirement for polygamy in Law no. I of 1974 concerning marriage and in the Compilation of Islamic Law (KHI) including its implementation in several decisions on polygamy cases in the Religious Court (PA) of Ex Surakarta Regency. This type of research is field research using a socio-juridical approach. The results of this study conclude: 1) The requirements for polygamy as regulated in Law no. I of 1974 and KHI are complementary. While Law no. I of 1974 in article 5 specifies five conditions for polygamy, KHI mentions only three conditions. 2) In general, the reasons put forward by husbands for polygamy are always related to the condition of the wife who is unable to carry out her obligations. 3) Judges, in deciding polygamy cases, do not only base the reasons put forward by the husband but also make other considerations, especially related to matters of the benefit and welfare of the applicant’sfamily