bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the heartbeat-evoked potential are associated with functional seizures
Authors: Elkommos Samia , Martin-Lopez David , Koreki Akihiro , Jolliffe Claire , Kandasamy Rohan , Mula Marco , Critchley Hugo D , Edwards Mark J , Garfinkel Sarah , Richardson Mark P , Yogarajah Mahinda 
Published: May 2023

BackgroundPatients with functional seizures (FS) can experience dissociation (depersonalisation) before their seizures. Depersonalisation reflects disembodiment, which may be related to changes in interoceptive processing. The heartbeat-evoked potential (HEP) is an electroencephalogram (EEG) marker of interoceptive processing.AimTo assess whether alterations in interoceptive processing indexed by HEP occur prior to FS and compare this with epileptic seizures (ES).MethodsHEP amplitudes were calculated from EEG during video-EEG monitoring in 25 patients with FS and 19 patients with ES, and were compared between interictal and preictal states. HEP amplitude difference was calculated as preictal HEP amplitude minus interictal HEP amplitude. A receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of HEP amplitude difference in discriminating FS from ES.ResultsThe FS group demonstrated a significant reduction in HEP amplitude between interictal and preictal states at F8 (effect size rB=0.612, false discovery rate (FDR)-corrected q=0.030) and C4 (rB=0.600, FDR-corrected q=0.035). No differences in HEP amplitude were found between states in the ES group. Between diagnostic groups, HEP amplitude difference differed between the FS and ES groups at F8 (rB=0.423, FDR-corrected q=0.085) and C4 (rB=0.457, FDR-corrected q=0.085). Using HEP amplitude difference at frontal and central electrodes plus sex, we found that the ROC curve demonstrated an area under the curve of 0.893, with sensitivity=0.840 and specificity=0.842.ConclusionOur data support the notion that aberrant interoception occurs prior to FS. Changes in HEP amplitude may reflect a neurophysiological biomarker of FS and may have diagnostic utility in differentiating FS and ES.
Occurrence of adverse events and change in disease activity after initiation of etanercept in paediatric patients with juvenile psoriatic arthritis in the CARRA Registry
Authors: Correll Colleen K , Stryker Scott , Collier David , Phillips Thomas A , Dennos Anne C , Balevic Stephen J , Beukelman Timothy 
Published: May 2023

ObjectiveEtanercept is commonly used to treat juvenile idiopathic arthritis, including juvenile psoriatic arthritis (JPsA); however, information on etanercept’s safety and effectiveness in clinical practice is limited. We used data from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry to evaluate etanercept’s safety and effectiveness in JPsA in clinical practice.MethodsWe analysed safety and effectiveness data for paediatric patients enrolled in the CARRA Registry who had a JPsA diagnosis and had used etanercept. Safety was assessed by calculating rates of prespecified adverse events of special interest (AESIs) and serious adverse events (SAEs). Effectiveness was assessed by a variety of disease activity measures.ResultsOverall, 226 patients had JPsA and received etanercept; 191 met criteria for safety analysis and 43 met criteria for effectiveness analysis. AESI and SAE incidence rates were low. There were five events: three uveitis, one new-onset neuropathy and one malignancy. Incidence rates were 0.55 (95% CI: 0.18, 1.69), 0.18 (95% CI: 0.03, 1.29) and 0.13 (95% CI: 0.02, 0.09) per 100 patient-years for uveitis, neuropathy and malignancy, respectively. Etanercept showed effectiveness for JPsA treatment; 7 of 15 (46.7%) had an American College of Rheumatology-Pediatric Response 90, 9 of 25 (36.0%) had a clinical Juvenile Arthritis Disease Activity Score 10-joint ≤1.1 and 14 of 27 (51.9%) had clinically inactive disease at the 6-month follow-up.ConclusionData in the CARRA Registry showed that etanercept treatment was safe in treating children with JPsA, with low AESIs and SAEs. Etanercept was also effective, even when assessed in a small sample size.
Alteration of innate lymphoid cell homeostasis mainly concerns salivary glands in primary Sjögren’s syndrome
Authors: Kawka Lou , Felten Renaud , Schleiss Cédric , Fauny Jean-Daniel , Le Van Quyen Pauline , Dumortier Hélène , Monneaux Fanny , Gottenberg Jacques-Eric 
Published: May 2023

ObjectiveInnate lymphoid cells (ILCs) are a cell population implicated in the pathogenesis of various chronic inflammatory diseases, but little is known about their role in primary Sjögren’s syndrome (pSS). The aim of this study was to assess the frequency of ILC subsets in peripheral blood (PB) and their quantity and location in minor salivary glands (MSGs) in pSS.MethodsThe frequency of ILC subsets was analysed in the PB of patients with pSS and healthy controls (HCs) by flow cytometry. The amount and location of ILC subsets in MSGs were studied in patients with pSS and sicca controls by immunofluorescence assay.ResultsIn PB, the frequency of ILC subsets did not differ between patients with pSS and HCs. The circulating frequency of the ILC1 subset was increased in patients with pSS with positive anti-SSA antibodies and that of the ILC3 subset was reduced in patients with pSS with glandular swelling. In MSGs, the ILC3 number was higher in lymphocytic-infiltrated than non-infiltrated tissue in patients with pSS and normal glandular tissues in sicca controls. The ILC3 subset was preferentially located at the periphery of infiltrates and was more abundant in small infiltrates of recently diagnosed pSS.ConclusionAltered ILC homeostasis mainly concerns salivary glands in pSS. Most ILCs in MSGs consist of the ILC3 subset, located at the periphery of lymphocytic infiltrates. The ILC3 subset is more abundant in smaller infiltrates and in recently diagnosed pSS. It might play a pathogenic role in the development of T and B lymphocyte infiltrates in the early stages of pSS.
Growth and survival of native wetland species in shallow capped centrifuged tailings and co-mixed tailings: a meso-scale greenhouse study
Authors: Degenhardt Dani , Van Dongen Angeline , Hudson Jessica J. , Utting Nicholas , Schreiber Stefan G. 
Published: May 2023

This 3-year meso-scale greenhouse study used 55-gallon columns to evaluate the survival and growth of boreal wetland communities planted on centrifuge (CF) tailings and co-mixed (CM) tailings capped with different reclamation cover soil capping designs. The CF tailings were capped with a shallow layer (10 and 30 cm) of peat reclamation material (PRM) and the CM tailings were capped with a shallow layer (5 cm) of PRM above 15 or 35 cm of reclamation subsoil (till). After 3 years, plant survival and growth on CF tailings showed significant improvement with a 10 cm PRM cap compared to the uncapped tailings, and plants growing on a 30 cm PRM cap outperformed those on the 10 cm PRM cap. Plant growth on CM tailings was significantly improved with a soil cover containing 5 cm PRM and at least 15 cm till. Among the seven native wetland species included in this study, the top performing species in terms of survival and above-ground biomass were Salix bebbiana, Scirpus microcarpus, and Carex aquatilis.
Association of HIV Infection and Incident Abdominal Aortic Aneurysm Among 143 001 Veterans
Authors: Filipkowski Alexandra M. , Kundu Suman , Eden Svetlana K. , Alcorn Charles W. , Justice Amy C. , So-Armah Kaku A. , Tindle Hilary A. , Wells Quinn S. , Beckman Joshua A. , Freiberg Matthew S. , Aday Aaron W. 
Published: May 2023

Background:
People with HIV (PWH) have an increased risk of cardiovascular disease. Previous cross-sectional data suggest there is a higher prevalence of abdominal aortic aneurysm (AAA) in PWH than in those without HIV. Whether PWH have an increased risk of incident AAA compared with those without HIV is unknown.

Methods:
We analyzed data among participants without prevalent AAA from the Veterans Aging Cohort Study, a prospective, observational, longitudinal cohort of veterans with HIV matched 1:2 with veterans without HIV infection. We calculated AAA rates by HIV status and assessed the association between HIV infection and incident AAA using Cox proportional hazards models. We defined AAA using the International Classification of Diseases, 9th or 10th revision, or Current Procedural Terminology codes and adjusted all models for demographic characteristics, cardiovascular disease risk factors, and substance use. Secondary analyses examined the association between time-varying CD4+ T-cell count or HIV viral load and incident AAA.

Results:

Among 143 001 participants (43 766 with HIV), over a median follow-up of 8.7 years, there were 2431 incident AAA events (26.4% among PWH). Rates of incident AAA per 1000 person-years were similar among PWH (2.0 [95% CI, 1.9–2.2]) and people without HIV (2.2 [95% CI, 2.1–2.3]). There was no evidence that HIV infection increased the risk of incident AAA compared with no HIV infection (adjusted hazard ratio, 1.02 [95% CI, 0.92–1.13]). In adjusted analyses with time-varying CD4+ T-cell counts or HIV viral load, PWH with CD4+ T-cell counts <200 cells/mm
3
(adjusted hazard ratio, 1.29 [95% CI, 1.02–1.65]) or HIV viral load ≥500 copies/mL (adjusted hazard ratio, 1.29 [95% CI, 1.09–1.52]) had an increased risk of AAA compared with those without HIV.

Conclusions:
HIV infection is associated with an increased risk of AAA among those with low CD4+ T-cell counts or elevated HIV viral load over time.
ExoCounter Assays Identify Women Who May Develop Early-Onset Preeclampsia From 12.5 μL First-Trimester Serum by Characterizing Placental Small Extracellular Vesicles
Authors: Jiang Shuhan , Zhang Wei , Cao Qing , Rahbar Maryam , Cooke William , Ono Masayuki , Fujimaki Kenichi , Saito Atsushi , Itonaga Makoto , Oda Kenta , Redman Christopher , Vatish Manu 
Published: May 2023

Background:
Preeclampsia is a major cause of maternal and perinatal morbidity and mortality worldwide. Identifying women with high risk of developing preeclampsia in early pregnancy remains challenging. Extracellular vesicles released from the placenta offer an attractive biomarker but have been elusive to quantify.

Methods:
Here, we tested ExoCounter, a novel device that immunophenotypes size-selected small extracellular vesicles <160 nm, for its ability to perform qualitative and quantitative placental small extracellular vesicles (psEV) analysis. To investigate disease-specific and gestational age-specific changes, we analyzed psEV counts in maternal plasma samples taken at each of the 3 trimesters from women who had (1) normal pregnancy (n=3); (2) women who developed early-onset preeclampsia (EOPE; n=3); and (3) women who developed late-onset preeclampsia (n=4) using 3 antibody pairs, CD10-placental alkaline phosphatase (PLAP), CD10-CD63, and CD63-PLAP. We further validated the findings in first-trimester serum samples among normal pregnancy (n=9), women who developed EOPE (n=7), and women who developed late-onset preeclampsia (n=8).

Results:

We confirmed that CD63 was the major tetraspanin molecule coexpressed with PLAP—a known placental extracellular vesicles marker on psEV. Higher psEV counts for all 3 antibody pairs were detected in the plasma of women who developed EOPE than the other 2 groups in the first trimester, which persisted through the second and third trimesters. Significantly higher CD10-PLAP (
P
<0.01) and CD63-PLAP (
P
<0.01) psEV counts were validated in the serum of the first trimester of women who developed EOPE compared with normal pregnancy.

Conclusions:
Application of the ExoCounter assay developed here could identify patients at risk of developing EOPE in the first trimester, thereby providing a window of opportunity for early intervention.
A Lesson with Francis Bacon Forced Me to See Outside the Software Box
Authors: Diaz Nelson J. 
Published: May 2023

Abstract
Computers became more standard in the early 1980s, and science and technology were influencing artists like the author. He began using a supercomputer and FORTRAN 77 software to define a non-Euclidean geometry model using conformal mapping to create art. A series of twisted and curved space images was manifested, reflective of Albert Einstein’s theories of general and special relativity. It was the author’s encounter with Edward Teller, “father of the H-bomb,” that led the author to artist Francis Bacon. It was a private lesson with the artist that forced the author out of the box and into his own visual world.
The Pandemic in Words: Tracking Fast Semantic Changes via a Large-Scale Word Association Task
Authors: Laurino Julieta , De Deyne Simon , Cabana Álvaro , Kaczer Laura 
Published: May 2023

AbstractMost words have a variety of senses that can be added, removed, or altered over time. Understanding how they change across different contexts and time periods is crucial for revealing the role of language in social and cultural evolution. In this study we aimed to explore the collective changes in the mental lexicon as a consequence of the COVID-19 pandemic. We performed a large-scale word association experiment in Rioplatense Spanish. The data were obtained in December 2020, and compared with responses previously obtained from the Small World of Words database (SWOW-RP, Cabana et al., 2023). Three different word-association measures detected changes in a word’s mental representation from Precovid to Covid. First, significantly more new associations appeared for a set of pandemic-related words. These new associations can be interpreted as incorporating new senses. For example, the word ‘isolated’ incorporated direct associations with ‘coronavirus’ and ‘quarantine’. Second, when analyzing the distribution of responses, we observed a greater Kullback-Leibler divergence (i.e., relative entropy) between the Precovid and Covid periods for pandemic words. Thus, some words (e.g., ‘protocol’, or ‘virtual’) changed their overall association patterns due to the COVID-19 pandemic. Finally, using semantic similarity analysis, we evaluated the changes between the Precovid and Covid periods for each cue word’s nearest neighbors and the changes in their similarity to certain word senses. We found a larger diachronic difference for pandemic cues where polysemic words like ‘immunity’ or ‘trial’ increased their similarity to sanitary/health words during the Covid period. We propose that this novel methodology can be expanded to other scenarios of fast diachronic semantic changes.
The Agent Preference in Visual Event Apprehension
Authors: Isasi-Isasmendi Arrate , Andrews Caroline , Flecken Monique , Laka Itziar , Daum Moritz M. , Meyer Martin , Bickel Balthasar , Sauppe Sebastian 
Published: May 2023

Abstract
A central aspect of human experience and communication is understanding events in terms of agent (“doer”) and patient (“undergoer” of action) roles. These event roles are rooted in general cognition and prominently encoded in language, with agents appearing as more salient and preferred over patients. An unresolved question is whether this preference for agents already operates during apprehension, that is, the earliest stage of event processing, and if so, whether the effect persists across different animacy configurations and task demands. Here we contrast event apprehension in two tasks and two languages that encode agents differently; Basque, a language that explicitly case-marks agents (‘ergative’), and Spanish, which does not mark agents. In two brief exposure experiments, native Basque and Spanish speakers saw pictures for only 300 ms, and subsequently described them or answered probe questions about them. We compared eye fixations and behavioral correlates of event role extraction with Bayesian regression. Agents received more attention and were recognized better across languages and tasks. At the same time, language and task demands affected the attention to agents. Our findings show that a general preference for agents exists in event apprehension, but it can be modulated by task and language demands.
Eye Movement Traces of Linguistic Knowledge in Native and Non-Native Reading
Authors: Berzak Yevgeni , Levy Roger 
Published: May 2023

Abstract
The detailed study of eye movements in reading has shed considerable light into how language processing unfolds in real time. Yet eye movements in reading remain inadequately studied in non-native (L2) readers, even though much of the world’s population is multilingual. Here we present a detailed analysis of the quantitative functional influences of word length, frequency, and predictability on eye movement measures in reading in a large, linguistically diverse sample of non-native English readers. We find many similar qualitative effects as in L1 readers, but crucially also a proficiency-sensitive “lexicon-context tradeoff”. The most proficient L2 readers’ eye movements approach an L1 pattern, but as L2 proficiency diminishes, readers’ eye movements become less sensitive to a word’s predictability in context and more sensitive to word frequency, which is context-invariant. This tradeoff supports a rational, experience-dependent account of how context-driven expectations are deployed in L2 language processing.
Androsace artvinensis sp. nov. (Primulaceae): A new species from northeastern Anatolia, Turkey
Authors: SEFALI ABDURRAHMAN , YAPAR YAKUP 
Published: May 2023

Androsace artvinensis (Primulaceae) from Artvin province (northeastern Anatolia) has been described as a new species to science. The new species is morphologically similar to A. armeniaca var. macrantha but differs from it by several morphological characters, such as bracts shape, calyx (calyx length and lobes), corolla (corolla length, lobes, and indumentum), hairs, leaves, pollen features, and habitat preference. Diagnostic morphological characteristics, a full description, and a distribution map are provided.
How Governor Directives Changed Health Workforce Flexibility in Response to the COVID-19 Pandemic
Authors: Ziemann Margaret , Strasser Julia , Krips Maddie , Yang Y. Tony , Pittman Patricia 
Published: May 2023

Objectives: In times of heightened population health needs, the health workforce must respond quickly and efficiently, especially at the state level. We examined state governors’ executive orders related to 2 key health workforce flexibility issues, scope of practice (SOP) and licensing, in response to the COVID-19 pandemic. Methods: We conducted an in-depth document review of state governors’ executive orders introduced in 2020 in all 50 states and the District of Columbia. We conducted a thematic content analysis of the executive order language using an inductive process and then categorized executive orders by profession (advanced practice registered nurses, physician assistants, and pharmacists) and degree of flexibility granted; for licensing, we indicated yes or no for easing or waiving cross-state regulatory barriers. Results: We identified executive orders in 36 states containing explicit directives addressing SOP or out-of-state licensing, with those in 20 states easing regulatory barriers pertaining to both workforce issues. Seventeen states issued executive orders expanding SOP for advanced practice nurses and physician assistants, most commonly by completely waiving physician practice agreements, while those in 9 states expanded pharmacist SOP. Executive orders in 31 states and the District of Columbia eased or waived out-of-state licensing regulatory barriers, usually for all health care professionals. Conclusion: Governor directives issued through executive orders played an important role in expanding health workforce flexibility in the first year of the pandemic, especially in states with restrictive practice regulations prior to COVID-19. Future research should examine what effects these temporary flexibilities may have had on patient and practice outcomes or on permanent efforts to relax practice restrictions for health care professionals.
Transhiatal esophagectomy via mediastinoscopy versus sweet for T2 esophageal squamous cell carcinoma patients
Authors: Jiang Nanqing , Lu Yimin , Wang Jun 
Published: May 2023

Background The aim was to compare transhiatal esophagectomy via mediastinoscopy (TEM) with Sweet procedure for patients with T2 midpiece and distal esophageal squamous cell carcinoma (ESCC). Materials and Methods By virtue of propensity score matching, 42 T2 ESCC patients who underwent TEM ( n = 21) and Sweet procedure ( n = 21) were included. Both the short-term and long-term outcomes of these patients were observed. Results Compared with the Sweet procedure, the TEM procedure showed less operation time (133.8 ± 30.4 vs 171.2 ± 30.3 min, p = 0.038), reduced drainage volume in 24 h (83.8 ± 142.3 vs 665.2 ± 220.0 mL, p < 0.001), shorter reserving time of chest tube (26.2 ± 26.3 vs 82.8 ± 49.8 h, p < 0.001) and less dissected lymph nodes (12.4 ± 6.1 vs 17.0 ± 6.5, p = 0.041). The average survival period was 62.6 months for TEM group and 62.5 months for Sweet group ( p = 0.753). The COX regression showed that the nodal staging could be regarded as an independent prognostic factor ( p = 0.013), not the surgical method ( p = 0. 754). Conclusions The TEM procedure could reduce operative trauma compared with the Sweet procedure. The long-term survival rate of TEM group was acceptable. The lymph node resection was a major disadvantage of TEM procedure. The TEM procedure might be an alternate choice for T2 midpiece and distal ESCC patients, especially for patients who cannot tolerate transthoracic esophagectomy.
Complex relationships between inflammatory manifestations/type 1 and type 2 symptoms in systemic lupus erythematosus: A narrative literature review
Authors: Escoda Thomas , Jourde-Chiche Noémie , Granel Brigitte , Cornec Divi , Chiche Laurent 
Published: May 2023

Objective Recent studies have highlighted that systemic lupus erythematosus (SLE) is characterized by different types of symptoms: type 1 symptoms related to inflammation and disease activity and type 2 symptoms such as fatigue, anxiety-depression, and pain. Our aim was to investigate the relation between type 1 and type 2 symptoms, and their impact on health-related quality of life (HRQoL) in SLE. Methods A literature review was conducted about disease activity/type1 and type 2 symptoms. Articles in English published after 2000 were located on Medline via Pubmed. The articles chosen evaluated at least one type 2 symptom or HRQoL using a validated scale in adult patients. Results Overall, 182 articles were analyzed and 115 were retained including 21 randomized, controlled trials and corresponding to 36 831 patients. We found that in SLE, inflammatory activity/type 1 symptoms were mostly uncorrelated with type 2 symptoms and/or HRQoL. Several studies even showing an inverse relationship. No or weak correlation was observed in 85, 3% (92, 6%), 76, 7% (74, 4%) and 37, 5% (73, 1%) of studies (patients) for fatigue, anxiety-depression, and pain, respectively. For HRQoL, no or weak correlation was observed in 77, 5% of studies (88% of patients). Conclusion Type 2 symptoms are poorly correlated with inflammatory activity/type 1 symptoms in SLE. Possible explanations and implications for clinical care and therapeutic evaluation are discussed.