bluuebunny/crossref_metadata_2025_split huggingface dataset:
SnFe 2 O 4 Nanocatalyst for the Synthesis of Arylbenzimidazoles from Aqueous Cascade Reaction and the Computational Study of the Mechanism and Application of the Products as Putative Human Transmembrane Protein Activators
Authors: Jafari-Chermahini Mohammad Taqi , Tavakol Hossein 
Published: May 2023

Abstract

In this work, an efficient and green method has been presented to prepare arylbenzimidazoles via an aqueous one-pot two–step cascade reaction. The reaction conditions were optimized by varying the reaction parameters. The products were obtained using the reaction between aldehydes, malononitrile, and 1,2–phenylenediamine. Moreover, SnFe2O4 nanoparticles were used as the heterogeneous catalyst at room temperature under an inert atmosphere. The structural properties of synthesized arylbenzimidazoles were investigated by using FT-IR, NMR, and mass spectrometry. The morphology and composition of the catalyst have been defined by SEM, XRD, UV–Vis, FTIR, and Raman spectroscopy. Ten different arylbenzimidazoles derivatives were prepared in 70–98% yield and the structural properties of them were investigated using FT–IR, NMR, and mass spectrometr. The plausible reaction mechanism was proved using DFT calculations. Furthermore, molecular docking simulations identified that the synthesized arylbenzimidazoles as an activator of transmembrane proteins of the human innate immune system. The effectiveness of this new method for the synthesis of Arylbenzimidazoles has been proved by experimental data and DFT calculations. The usefulness of the product as Human Transmembrane Protein Activators was proved using Docking studies.
Tuning of the chiral nematic phase of cellulose nanocrystals by the adsorption of a short polymer on their surface
Authors: Voisin Hugo , Vasse Adèle , Bonnin Estelle , Cousin Fabrice , Capron Isabelle 
Published: May 2023

Abstract
Concentrated cellulose nanocrystals (CNC) suspensions are known to self-assemble into liquid crystalline cholesteric phase. However, the origin of this chirality transfer is still matter of discussion. In this work, we used a tailor-made biopolymer, xyloglucan (XG), at a very small molar mass (20,000 g/mol) that adsorb flat on the cellulose surface. We showed that the addition to a dispersion of CNC at 60 g/L of XG up to 10 g/L decreased the anisotropic volume fraction, increased the cholesteric pitch, and kept constant the inter-CNC distance implying a change in the twist angle and a lower chiral strength. These results indicate that a very limited modification of CNC in surface can induce important variation of the cholesteric order. Above 10 g/L XG, XG-covered CNCs decreased the cholesteric pitch and preferentially concentrated in the isotropic phase, decreasing the global cholesteric liquid crystal (CLC) order.
Mitochondrial transplantation combined with coenzyme Q10 improves mitochondrial function and induces full cardioprotection in aged rats with myocardial ischemia/reperfusion injury
Authors: Bafadam Soleyman , Mokhtari Behnaz , Vafaee Manoucheher Seyedi , Oskuye Zohreh Zavvari , Nemati Samira , badalzadeh Reza 
Published: May 2023

Abstract
Background:
Ischemic heart diseases (IHD) are among the major causes of mortality in elderly population. Although timely reperfusion is a commen treatment for IHD, it also causes additional damage to the ischemic myocardium known as ischemia/reperfusion (IR) injury. Considering the importance of preventing reperfusion injuries, we aimed to examine the combination effect of mitochondrial transplantation and coenzyme Q10 (CoQ10) in myocardial IR injury of aged rats.
Methods:
Seventy-two aged male Wistar rats were randomly divided into 6 groups: Sham, IR, CoQ10, mitochondrial transplantation (MT), combination therapy (MT+CoQ10), and vehicle. Myocardial IR injury was established by occlusion of the left anterior descending coronary artery and re-opening. Young male Wistar rats were used as mitochondria donors. Isolated mitochondria were injected intraventricularly (500µl of the respiration buffer containing 6×106±5×105 mitochondria) in MT receiving groups at the onset of reperfusion. CoQ10 (10mg/kg/day) was injected intraperitoneally for two weeks before IR induction. Twenty-four hours after reperfusion, hemodynamic parameters, myocardial infarct size (IS), LDH level, and cardiac mitochondrial function (mitochondrial ROS generation and membrane potential) were measured.
Result:
Combination of mitochondrial transplantation and CoQ10 improved hemodynamic index changes and reduced IS and LDH level (P<.05). It also decreased mitochondrial ROS generation and increased membrane potential (P<.05).
showed a significant cardioprotective effect. Combination therapy showed greater cardioprotective effects than single treatments.
Conclusion:
This study revealed that mitochondrial transplantation and CoQ10 combination treatment can be considered as a promising cardioprotective strategy to reduce myocardial IR injury in aging, in part by restoring mitochondrial function.
Associations among preoperative albumin concentration, coagulation status, and severity of postoperative complications in patients with abdominal trauma
Authors: Takematsu Toru , Kosumi Keisuke , Tajiri Takuya , Kanemitsu Kosuke , Mima Kosuke , Inoue Mitsuhiro , Mizumoto Takao , Kubota Tatsuo , Miyanari Nobutomo , Baba Hideo 
Published: May 2023

Abstract
Purpose
Abdominal trauma has many causes and requires rapid treatment. Because of injuries to multiple organs, cross-abdominal objective predictors derived from preoperative information are important for management. This study was performed to identify which preoperative clinical features are associated with worse postoperative complications.
Methods
Using our institutional database, we identified 80 consecutive patients who underwent emergency surgery after abdominal trauma from 2010 to 2020. We assessed the associations between clinical features and complications graded using the Clavien–Dindo (CD) classification.
Results
The most frequent causes of abdominal trauma were stab wounds (40%) and car accidents (38%). The most commonly injured organs were the small intestine (39%) and mesentery (16%). We observed a strong negative relationship between the CD classification and albumin level (r < −0.4, P < 0.0001) and strong positive relationships between the CD classification and the fibrinogen degradation product (FDP) level, D-dimer level, and blood transfusion volume (all r > 0.4, all P < 0.0001). In the logistic regression models, all four abovementioned variables were significantly associated with severe complications (all P < 0.04).
Conclusion
The albumin, FDP, and D-dimer levels and the blood transfusion volume might be useful predictors of postoperative complications in patients with abdominal trauma.
Transplantation of induced endothelial progenitor-like cells pretreated with Defined Factors promotes Diabetic Wound Healing
Authors: Cheng Fuyi , Zhang Yong , Jiang Qingyuan , Du Fei , Pan Cheng , Ye Yixin , Zhang lin , Su Dongsheng , Ren Yushuang , Zhao Pusong , Wang Huilin , Xu Hua , Su Xiaolan , Deng Hongxin 
Published: May 2023

Abstract
Diabetic foot disease (DFD) is a major public health concern and is characterized by impaired angiogenesis. Transplantation of endothelial progenitor cell (EPC) holds great potential for treating DFD. However, the poor cell survival of transplant-derived EPCs limits their beneficial effects. Here, we report a preconditioning scheme for the generation of endothelial progenitor-like cells by chemical induction in nutrients deprivation and D-glucose-containing conditions with TGF inhibitor sb431542. The preconditioned endothelial progenitor-like cells (pEPCs) were induced from human umbilical vein endothelial cells (huvecs) and the expression of CD34 was markedly upregulated (༞90%) in pEPCs. Furthermore, pEPCs have the potential to resist pathological environmental stress, which is characterized by their high cell viability, oxidative stress tolerance and enhanced tubulogenesis under simulated DFD conditions. The protective effect of preconditioning in pEPCs is partly achieved by activating the PI3K/AKT pathway to up-regulate the expression of Nrf2 and HIF-1α. Importantly, due to its enhanced retention and angiogenesis, the transplanted pEPCs showed improved therapeutic potential for wound regeneration in diabetic mice. Overall, this study explores a novel preconditioning condition and provides an easy and efficient strategy to obtain pEPCs, which could be an ideal cell source for treating DFD and for endothelialization of tissue-engineered constructs.
Quantifying Urban Carrying Capacity towards Sustainable Tourism in Labuan Bajo Flores, Indonesia: A GIS Spatial Analyses Approach
Authors: Sejati Anang Wahyu , Putri Savira Nur Afifah Kusuma , Tyas Wido Prananing , Buchori Imam , Handayani Wiwandari , Basuki Yudi , Barbarossa Ghiffari , Husna Isnaini Nur 
Published: May 2023

AbstractThis paper aims to explain the findings of an inquiry into urban carrying capacity as a factor in Labuan Bajo Flores tourism development planning. This study uses the superimpose method of GIS spatial modelling to analyse land, water, electricity, settlements, and waste carrying capacity. In 2042, it is expected that three of the five carrying capacity variables will experience a deficit, according to the data. The three deficiency variables are the availability of land, electricity, and water. In addition, these conditions are assessed through spatial distribution using GIS, which identifies four regions in the Labuan Bajo urban area that fall under the category of high-priority treatment. It implies that quick action is required to solve the carrying capacity issue in 2042. The treatment areas with the greatest carrying capacity are Labuan Bajo, Wae Kelambu, Batu Cermin, and Golo Bilas. Based on these findings, tourism development in Labuan Bajo must prioritize sustainability so that the spatial planning and allocation of tourist attractions are cognizant of carrying capacity in order to realize sustainable tourism, particularly in the urban area of Labuan Bajo.
Tadpole morphological characterization of Ranitomeya variabilis (Zimmermann &amp; Zimmermann, 1988) (Anura: Dendrobatidae), with skeleton, muscle system and inner organs
Authors: Regnet Ruth A. , Lukas Paul , Rödder Dennis , Wipfler Benjamin , Solé Mirco 
Published: May 2023

Abstract

In this study we morphologically examine larval specimens of Ranitomeya variabilis, which were breed in captivity and genetically determined to belong to the French Guiana population. We provide detailed data on the external morphology, chondrocranium, cranial muscle systems and inner organs of the tadpoles. Additionally, we provide essential characteristics for the recognition of the tadpoles of the different Ranitomeya species. The external morphology of the R. variabilis tadpoles was assessed by measurements and photographs of the specimens. Internal morphology was analysed using µCT images, µCT-based three dimensional reconstructions, and dissection of specimens for organ and muscle descriptions. The majority of the muscle configurations observed herein for larval specimens of R. variabilis are consistent with data presented in previous studies for larvae of other Ranitomeya species. In addition, several of the observed morphological characters are defined for different taxonomic levels within Dendrobatidae, e.g. the reduction of tectal cartilages and the insertion of the Muscular rectus cervicis on the third or fourth branchial arch. The absence of the anterolateral process of the ceratohyal in Ranitomeya and Dendrobates further strengthens their close relationship, in contrast to the more distantly related Epipedobates and Phyllobates where this structure is present. The absence of the musculi levator arcuum branchialium I and II, the musculus interhyoideus posterior and the musculus diaphragmatopraecordialis might be defining traits for Ranitomeya. Already a unique character observed in this study, is the fusion of the superficialis and profundus portion of the musculus levator longus for the R. variabilis larvae.
Algal Biomass, Biochar and Hydrochar from Chlorella Vulgaris for Cadmium Removal from Aqueous Streams
Authors: Sufian Jafar , Sari Mohamad Babakbari , Marchelli Filippo , Fiori Luca , Avanes Armen , Moradi Salahedin 
Published: May 2023

Abstract

Chlorella Vulgaris is an inexpensive and accessible raw material that can be evaluated for environmental remediation. As its derivatives have the potential for environmental pollutant removal, further investigations to evaluate their feasibility for this purpose are needed. This study aimed to investigate and compare the physiochemical properties of Chlorella Vulgaris algae biomass with biochar and hydrochar derived from it. This study was conducted in a completely randomized block design with three replicates at the University of Zanjan, Iran. The detailed physico-chemical characterization of three substances (algae biomass with biochar and hydrochar) was measured. Adsorption isotherms were used to explain the adsorption process. The effects of the adsorbents dosage (0.1, 0.2, 0.4, 0.8, 1, and 2 g), pH (3, 5, 6, 7, 8, and 9), initial cadmium (Cd) concentration (0, 2, 5, 10, 20, and 40 mg l− 1), and contact time (0, 5, 15, 30, 60, 90, and 180 minutes) on Cd removal were evaluated. The carbon content, ash content, volatile matter, and specific surface area of biochar and hydrochar are higher, while hydrogen, oxygen, nitrogen, and sulfur are lower compared to algae biomass. Results showed that FTIR spectra of algae biomass, biochar, and hydrochar followed a similar trend, but the corresponding biochar showed fewer peaks than microalgae, and the peaks were sharper and taller. For biochar, hydrochar, and algae biomass, the maximum adsorption capacities for Cd were 24.39, 23.58, and 16.56 mg g− 1, respectively. Optimum conditions for the highest removal of Cd were observed at the adsorbents dosage of 0.8 g l− 1, 30 mg l− 1 initial concentration of Cd solution, pH of 6, and contact time of 30 minutes. The adsorption isotherm data of Cd could be well-described by the Langmuir and Temkin models. The results indicated that biochar, hydrochar, and algae biomass could be used as a biosorbent for the removal of heavy metals from aqueous streams.
Duodenal Plasmablastic Lymphoma in HIV Negative Patient A rare presentation
Authors: Hussain Abbas Ali , Shah Aresha Masood , Kumar Sumeet 
Published: May 2023

Abstract

BackgroundPlasmablastic lymphoma is a rare type of Non-Hodgkin lymphoma, which generally presents an aggressive clinical course. It is strongly associated with HIV infection and the most common site of involvement is oral cavity.Case PresentationHere we describe an exceptionally rare case of a 24-years-old immunocompetent male patient with newly diagnosed Plasmablastic lymphoma of the Duodenum. Computed Tomography of the abdomen (triphasic) of the patient showed thickness at the 2nd part of the duodenum measuring 2.6cm in width and 16 cm in length.ConclusionsDuodenal involvement to the extent seen in our patient is exceptionally rare, and, to the best of our knowledge, has hardly been described. The main goal of the article is to review the literature and report a case.
Idiopathic subglottic stenosis arises at the epithelial interface of host and pathogen
Authors: Gelbard Alexander , Shilts Meghan H. , Strickland Britton , Motz Kevin , Tsai Hsiu-Wen , Boone Helen , Drake Wonder P. , Wanjalla Celestine , Smith Paula Marincola , Brown Hunter , Ramierez Marisol , Atkinson James B. , Powell Jason , Simpson John , Rajagopala Seesandra V. , Mallal Simon , Sheng Quanhu , Hillel Alexander T. , Das Suman R. 
Published: May 2023

Abstract
Background
Idiopathic subglottic stenosis (iSGS) is a rare fibrotic disease of the proximal airway affecting adult Caucasian women nearly exclusively. Life-threatening ventilatory obstruction occurs secondary to pernicious subglottic mucosal scar. Disease rarity and wide geographic patient distribution has previously limited substantive mechanistic investigation into iSGS pathogenesis.
Result
By harnessing pathogenic mucosa from an international iSGS patient cohort and single-cell RNA sequencing, we unbiasedly characterize the cell subsets in the proximal airway scar and detail their molecular phenotypes. Results show that the airway epithelium in iSGS patients is depleted of basal progenitor cells, and the residual epithelial cells acquire a mesenchymal phenotype. Observed displacement of bacteria beneath the lamina propria provides functional support for the molecular evidence of epithelial dysfunction. Matched tissue microbiomes support displacement of the native microbiome into the lamina propria of iSGS patients rather than disrupted bacterial community structure. However, animal models confirm that bacteria are necessary for pathologic proximal airway fibrosis and suggest an equally essential role for host adaptive immunity. Human samples from iSGS airway scar demonstrate adaptive immune activation in response to the proximal airway microbiome of both matched iSGS patients and healthy controls. Clinical outcome data from iSGS patients suggests surgical extirpation of airway scar and reconstitution with unaffected tracheal mucosa halts the progressive fibrosis.
Conclusion
Our data support an iSGS disease model where epithelial alterations facilitate microbiome displacement, dysregulated immune activation, and localized fibrosis. These results refine our understanding of iSGS and implicate shared pathogenic mechanisms with distal airway fibrotic diseases.
Cross-sectional and longitudinal associations of creatinine-to-cystatin C ratio with sarcopenia parameters in older adults
Authors: Kitgo Moe , Seino Satoshi , Shinkai Shoji , Nofuji Yu , Yokoyama Yuri , Abe Takumi , Taniguchi Yu , Amano Hidenori , Murayama Hiroshi , Kitamura Akihiko , Akishita Masahiro , Fujiwara Yoshinori 
Published: May 2023

Abstract
Objectives: Accumulating evidence from cross-sectional studies suggests that the serum creatinine-to-cystatin C ratio (CCR) may be a useful biomarker for sarcopenia. This study aimed to assess the cross-sectional and longitudinal associations between CCR and sarcopenia parameters in community-dwelling older adults.
Design: Longitudinal study.
Setting and Participants: This 6-year prospective cohort study included the repeated measurement data from 1,253 Japanese residents (662 males and 591 females) aged ≥65 years who underwent medical checkups in Kusatsu and Hatoyama, Japan. A total of 4,421 observations were collected.
Measurements: The CCR was grouped into quartiles by sex (Q1–Q4) using Q4 as the reference category. Skeletal muscle mass index (SMI) measured using segmental multifrequency bioelectrical impedance analysis, handgrip strength (HGS), usual gait speed (UGS), and maximal gait speed (MGS) were measured repeatedly as sarcopenia parameters. The association between the CCR and changes in SMI, HGS, UGS, and MGS during the 6-year period were analyzed using a linear mixed-effects model.
Results: At baseline, SMI, HGS, and MGS were significantly inversely associated with the CCR quartile (P for trend < 0.001). During the 6-year follow-up period, significantly greater declines in SMI (B = −0.01 kg/m2/year; P = 0.044 for group-by-time interaction) and MGS (B = −0.008 m/sec/year; P = 0.041 for group-by-time interaction) were observed in participants with a baseline CCR in Q1 compared with those with a CCR in Q4. The baseline UGS and change in UGS did not differ significantly according to the baseline CCR quartile.
Conclusions: CCR can be a useful biomarker for the decline in clinical status and the subsequent risk of reduction in multiple sarcopenia parameters. CCR may identify those at high risk of sarcopenia and lead to early intervention, even in older adults whose physical function is difficult to assess.
Decision-making and coordination of green supply chain with CSR responsibility under loss aversion
Authors: Li Wenxia , Liu Linzhong , Li Yu , Li Zhuo 
Published: May 2023

Abstract
To investigate the influence of manufacturers' loss aversion preference and retailers' CSR behaviour on green supply chain decision making, a green CSR supply chain game model with three different Stackelberg structures for centralized decision making, manufacturers' rational preference and loss aversion preference are constructed using the Nash bargaining solution as the loss aversion reference point, and a combined revenue sharing-liability sharing contract is introduced to achieve green supply chain coordination under the two decentralized structures.The results show that the retailer's CSR responsibility is conducive to the green development of the supply chain, but the manufacturer's loss aversion not only damages the retailer's profits, but also damages its own profits;In addition, when the manufacturer's rational preference, with the improvement of the retailer's CSR level, the effective coordination interval length of the coordination factor under the combined contract increases, and the supply chain coordination flexibility increases; When the manufacturer's loss aversion preference increases, the upper and lower limits of the coordination factor of the combined contract will increase with the increase of the loss aversion preference, and the length of the coordination interval will also decrease with the increase of the loss aversion preference, which has a negative impact on the cooperation between the supply chain members.
Light-Stimulated Micromotor Swarms in an Electric Field with Versatile Spatial, Temporal, and Mode Control
Authors: Liang Zexi , Joh Hyungmok , Lian Bin , Fan Donglei (Emma) 
Published: May 2023

Abstract
Swarming, a phenomenon widely present in nature, is a hallmark of non-equilibrium living systems that harness external energy into collective locomotion. The constituting units with sizes ranging from nanometers to meters form complex patterns and synchronous motion. The creation and study of swarms made of artificial active matter may provide insights to their biological counterparts and shed light to the rules of life. Here, we propose an innovative concept and associated actuation mechanism for rationally creating multi-modal swarms with unprecedented spatial, temporal, and mode control. The research is realized in a system made of optoelectric semiconductor nanorods that can rapidly morph into three distinct modes, i.e., network formation, collectively enhanced rotation, and droplet-like clustering, and switch in between with light stimulation in an electric field. Theoretical analysis and semi-quantitative modeling well explain the observation via understanding the competition between two countering effects: the electrostatic assembly for orderliness and electrospinning-induced disassembly for disorderliness. This work could inspire the rational creation of a new class of reconfigurable swarms for both fundamental research and emerging applications.