bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical digital ischemia and biliary cholangitis related to graft versus host disease: A case report and systematic literature review
Authors: Hidalgo Calleja Cristina , Montilla Morales Carlos Alberto , Sánchez González María Dolores , Pastor Navarro Sonia , Ibáñez Martínez Marta , Conde Ferreiros Alberto , López Corral Lucía 
Published: January 2023

Rationale:
Chronic graft versus host disease (cGVHD) is a systemic immune-mediated complication that occurs in approximately half of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT), and remains the leading cause of late morbidity and mortality. cGVHD involves a heterogeneous group of organic manifestations, many of which mimic autoimmune diseases such as scleroderma, primary biliary cholangitis, Sjögren syndrome and polymyositis.

Patient concerns:
A 60-years-old female with a history of allo-HCT developed de novo cGVHD 11 months after allo-HCT with isolated liver involvement. The patient presented with jaundice, cytolysis, cholestasis and concomitant acute digital ischemia. Liver biopsy and autoimmunity tests were performed and were found to be compatible with immune-mediated liver damage. Nailfold capillaroscopy revealed microangiopathy, characterized by avascular areas and some enlarged capillaries resembled an early systemic sclerosis pattern.

Diagnosis:
Biliary cholangitis-like and digital ischemia related to cGVHD.

Interventions:
The patient was treated with high-dose prednisone and ursodeoxycholic acid, and extracorporeal photopheresis. The patient required hospital admission for administration of intravenous prostacyclin due to refractory Raynaud syndrome.

Outcomes:
After 6 to 8 weeks, the patient achieved a good response, with evident clinical improvement and progressive normalization of liver function.

Lessons:
cGVHD is a multiorgan pathological condition, and this case emphasizes that a multidisciplinary team, including rheumatologists, should be involved in the follow-up of allo-transplant patients to ensure that the clinical complications are adequately addressed. Early intervention is critical for improving patient’ prognosis.
In addition, we performed a systemic literature review based on published case articles on hepatic cGVHD and digital ischemia published up to August 2022. To the best of our knowledge, this is the first reported case of such an association.
A leading bibliometric author does not have a dominant contribution to research based on the CJAL score: Bibliometric analysis
Authors: Tam Hon-Pheng , Hsieh Wan-Ting , Chien Tsair-Wei , Chou Willy 
Published: January 2023

Background:
A total of 22,367 bibliometric articles have been indexed by Web of Science (WoS). The most significant contribution to the field has not yet been identified through bibliometric analysis. A comparison of individual research achievements (IRAs) and trend analysis of article citations are required after extracting bibliometric articles. The study aimed to confirm whether the leading author has a dominant RA and which articles are worth reading for readers using trend analysis.

Methods:
We identified authors with at least 100 articles related to bibliometrics in the WoS core collection. A total of 399 articles were collected to cluster author collaborations. Co-word analysis and chord diagrams were used to match chief authors in clusters with Keywords Plus in WoS core collection. The category, journal impact factor, authorship, and L-index (CJAL) score and the absolute advantage coefficient (AAC) were used to compare IRAs and identify the leading author who dominated the field significantly beyond the next 2 authors. In addition to network charts and chord diagrams, 4 visualizations were used to report study results, including a Sankey diagram, a dot plot, a temporal trend graph, and a radar plot. The temporal bubble graph was used to select articles that deserve to be read.

Results:
The top 3 authors were Lutz Bornmann, Yuh-Shan Ho, and Giovanni Abramo, with CJAL scores of 176.22, 176.02, and 112.06, respectively, from Germany, Italy, and Taiwan. Based on the weak dominance coefficient (AAC = 0.20 < 0.70), it is evident that the leading bibliometric author has no such significant power beyond the next 2 leading authors in IRAs. A trend analysis of the last 4 years was used to illustrate the 2 articles that deserve to be read.

Conclusion:
Three leading authors were identified through a co-word analysis of bibliometrics. There was no evidence of an author who possessed a dominant position due to a lower AAC on the leading author. The CJAL score and the AAC can be applied to many bibliographical studies in the future rather than being limited to bibliometric studies that evaluate the leading authors in a field, as we did in this study.
Efficacy of 11 anticoagulants for the prevention of venous thromboembolism after total hip or knee arthroplasty: A systematic review and network meta-analysis
Authors: Huang Zhihao , Xu Xinru , Xu Dan , Zhao Pengfei , Zou Miao 
Published: January 2023

Background:
To systematically review the efficacy of 11 anticoagulants in the treatment of venous thromboembolism (VTE) after total hip or knee arthroplasty.

Methods:
PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, Wanfang Data, VIP, and China Biology Medicine databases were electronically searched for studies assessing the efficacy of different anticoagulants for the prevention of VTE after total hip or knee arthroplasty from January 1, 2010, to January 27, 2022. Two reviewers independently screened the literature, extracted data, and graded the evidence using Confidence in Network Meta-Analysis. The network meta-analysis was then performed using Stata 16.0 software and R 4.1.0 software.

Results:
A total of 61 articles were included. The results of network meta-analysis showed that apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban were the most effective anticoagulants for the prevention of deep vein thrombosis in patients undergoing total hip or knee arthroplasty (P < .05), while there was no difference in the efficacy among the anticoagulants for the prevention of pulmonary embolism (P > .05).

Conclusion:
Apixaban, edoxaban, fondaparinux, rivaroxaban, and darexaban have the best efficacy for the prevention of VTE after total hip or knee arthroplasty.
Metformin-associated severe lactic acidosis combined with multi-organ insufficiency induced by infection with Aeromonas veronii: A case report
Authors: Xia Yu , Zhu Xiaofeng , Wu Changxue 
Published: January 2023

Rationale:
Lactic acidosis is a disease in which lactic acid accumulates in the blood and causes acidosis in the patient. The criteria for diagnosis are a lactate level of >2 mmol/L in the blood and a blood pH of <7.2.

Patient concerns:
A 72-year-old Asian female with a history of diabetes for 20+ years was admitted to the hospital with the chief complaint of “dry mouth, polydipsia for 20+ years, loss of appetite for 5+ days, vomiting for 1-day.” She was admitted with a blood gas pH of 6.795, and a lactate level of >30 mmol/L.

Diagnoses:
Type 2 diabetes mellitus with lactic acidosis, ketoacidosis, chronic renal insufficiency, hypertensive disease, and coronary arteriosclerotic heart disease.

Interventions:
She was treated with symptomatic rehydration and ketone reduction immediately, but then became unconscious and was admitted to the intensive care unit, where she was administered symptomatic support and continuous renal replacement therapy. As the blood culture showed Aeromonas veronii, she was administered a sensitive antibiotic in conjunction.

Outcomes:
However, after achieving a stable internal environment and good infection control, the patient’s family decided to discontinue treatment because of persistent heart failure with acute exacerbation of chronic renal insufficiency complicated by gastrointestinal bleeding.

Lessons:
Lactic acidosis has low incidence, poor prognosis, and high morbidity and mortality rates. Special attention should be paid to infection-induced acidosis, especially in patients with combined multi-organ insufficiency. Early diagnosis and active management can improve the patient prognosis.
A case report of hypertrophic olivine degeneration complicated with OSAHS exacerbation: Case report and retrospective analysis
Authors: Geng Minxia , Wang Lulu , Xing Jiahao , Li Shuang , Dong Lulu , Jiang Chao , Wang Tianjun 
Published: January 2023

Rationale:
Hypertrophic subolivine degeneration (HOD) was destroyed by Guillain–Mollaret triangle (GMT) due to various injuries, resulting in anterograde cavity-like degeneration of the lower olive nucleus. In addition, the brain stem is related to the muscle coordination of the upper respiratory tract. Obstructive sleep apnea hypopnea syndrome may affect the respiratory center due to the injury of the brain stem. Brain stem hemorrhage damage GMT, resulting in transsynaptic neuronal degeneration. Clinical manifestations can be complex, and enhanced magnetic resonance imaging can be helpful in distinguishing them.

Patient concerns:
HOD is a self-limiting disease with no effective treatment and a long course of disease. Most patients can improve their symptoms after symptomatic treatment, and some patients can relieve their symptoms by themselves after 3 to 4 years.

Diagnosis interventions:
The limbs wobble involuntarily. His clinical symptoms and signs are consistent with HOD. Imaging with a clear primary lesion confirmed HOD. After treatment with antiepileptic drugs, the patient’s symptoms were relieved. Moreover, the patient had snoring and apnea, and respiratory sleep monitoring showed moderate obstructive sleep apnea hypopnea syndrome, which was treated with noninvasive ventilator.

Outcomes:
After treatment with antiepileptic drugs and noninvasive ventilator, the patient’s symptoms were significantly relieved.

Lessons:
HOD is a rare clinical disorder. Therefore, for similar patients, more attention should be paid to early diagnosis and treatment to avoid missed diagnosis, misdiagnosis and unnecessary intervention measures. The diagnosis can be confirmed by primary disease, clinical symptoms, and imaging based on GMT.
Severe Maternal Morbidity in Georgia, 2009–2020
Authors: Kramer Michael R. , Labgold Katie , Zertuche Adrienne D. , Runkle Jennifer D. , Bryan Michael , Freymann Gordon R. , Austin David , Adams E. Kathleen , Dunlop Anne L. 
Published: January 2023

Background:The increasing focus of population surveillance and research on maternal—and not only fetal and infant—health outcomes is long overdue. The United States maternal mortality rate is higher than any other high-income country, and Georgia is among the highest rates in the country. Severe maternal morbidity (SMM) is conceived of as a “near miss” for maternal mortality, is 50 times more common than maternal death, and efforts to systematically monitor SMM rates in populations have increased in recent years. Much of the current population-based research on SMM has occurred in coastal states or large cities, despite substantial geographical variation with higher maternal and infant health burdens in the Southeast and rural regions.Methods:This population-based study uses hospital discharge records linked to vital statistics to describe the epidemiology of SMM in Georgia between 2009 and 2020.Results:Georgia had a higher SMM rate than the United States overall (189.2 vs. 144 per 10,000 deliveries in Georgia in 2014, the most recent year with US estimates). SMM was higher among racially minoritized pregnant persons and those at the extremes of age, of lower socioeconomic status, and with comorbid chronic conditions. SMM rates were 5 to 6 times greater for pregnant people delivering infants <1500 grams or <32 weeks’ gestation as compared with those delivering normal weight or term infants. Since 2015, SMM has increased in Georgia.Conclusion:SMM represents a collection of life-threatening emergencies that are unevenly distributed in the population and require increased attention. This descriptive analysis provides initial guidance for programmatic interventions intending to reduce the burden of SMM and, subsequently, maternal mortality in the US South.
Collaborative Therapist-Patient Decision Making: A Power-Based Exercise Program for an Adolescent With CMT1A
Authors: Hedgecock James B. , Kelley Carolyn , Jensen Allison , Rapport Mary Jane 
Published: January 2023

Purpose:
The purpose of this case report is to describe an episode of care for an adolescent with Charcot Marie Tooth disease (CMT) using a power-based progressive resistance exercise (PRE) and balance program to improve performance of participant-defined goals with added description through the voice of the patient as “participant lived experience.”

Summary of Key Points:
Participant discussion demonstrates improvement of functional performance for an adolescent with CMT subtype 1A (CMT1A), a progressive neuromuscular disorder. Function and participation-specific movement observation, clinical evaluation, and resistance training fostered appropriate program design and intervention dosing.

Conclusions and Recommendations for Clinical Practice:
A power-based progressive resistance exercise and balance program with design based on participant-defined goals was feasible, well tolerated, and successful for an adolescent with CMT1A. Inclusion of viewpoints of the “lived experience” provides deeper insight into patient perspective and clinical outcomes. Outcomes may improve when intervention is specifically dosed to participant goals and individual muscle performance requirements for targeted tasks.
Opportunities for Participation: A Mapping Review of Inclusive Physical Activity for Youth With Disabilities
Authors: Sawade Samantha 
Published: January 2023

Introduction:
The purpose of this review is to map the literature regarding group-based inclusive and adapted physical activity opportunities for youth with disabilities, and to identify gaps in that literature.

Methods:
A comprehensive search was completed across 5 electronic databases. Inclusion criteria were for any study type with youth ages 3 to 21 years who participated in any adapted group-based physical activity program, or their caregivers.

Results:
A total of 30 studies were included from 13 countries, consisting of more than 15 types of physical activity. Levels of evidence ranged from 2b to 4 as per the Oxford Centre for Evidence-Based Medicine Levels of Evidence system.

Conclusions:
A small but growing body of evidence exists regarding group-based inclusive and adapted physical activity. A dearth of evidence exists for rurally residing programs and programs that include children with severe disabilities.
Informing the Physical Therapy Management of Congenital Muscular Torticollis Clinical Practice Guideline: A Systematic Review
Authors: Castilla Adrianna , Gonzalez Mariah , Kysh Lynn , Sargent Barbara 
Published: January 2023

Purpose:
To systematically review current evidence on the physical therapy assessment, intervention, and prognosis of congenital muscular torticollis (CMT) to inform the update to the 2018 CMT Clinical Practice Guideline (CPG).

Methods:
Six databases were searched for studies that informed assessment, intervention, and prognosis for physical therapy management of infants with CMT.

Results:
Fifteen studies were included. Four studies investigated the psychometric properties of new and established assessments. Six studies informed the feasibility and efficacy of first-choice and supplemental interventions including traditional Chinese medicine and neural and visceral manipulation. One qualitative study found that parents of infants with mild and severe CMT had different concerns. Five studies informed prognosis, including factors associated with treatment duration, clinical outcomes, and use of supplemental interventions.

Conclusion:
Newer evidence reaffirms 5 of 17 recommendations of the 2018 CMT CPG and could increase the recommendation strength to strong for neck passive range of motion.
The Role of 68Ga-FAPI PET/CT in Detection of Metastatic Lobular Breast Cancer
Authors: Eshet Yael , Tau Noam , Apter Sara , Nissan Noam , Levanon Keren , Bernstein-Molho Rinat , Globus Ofer , Itay Amit , Shapira Tal , Oedegaard Cecilie , Gorfine Malka , Eifer Michal , Davidson Tima , Gal-Yam Einav , Domachevsky Liran 
Published: January 2023

Purpose
Invasive lobular breast cancer (ILC) may be hard to detect using conventional imaging modalities and usually shows less avidity to 18F-FDG PET/CT. 68Ga–fibroblast activation protein inhibitor (FAPI) PET/CT has shown promising results in detecting non–18F-FDG–avid cancers. We aimed to assess the feasibility of detecting metastatic disease in patients with non–18F-FDG–avid ILC.

Methods
This prospective study included patients with metastatic ILC, infiltrative to soft tissues, which was not 18F-FDG avid. The patients underwent 68Ga-FAPI PET/CT for evaluation, which was correlated with the fully diagnostic CT performed at the same time.

Results
Seven women (aged 57 ± 10 years) were included. Among the 30 organs and structures found to be involved by tumor, the number of findings observed by FAPI PET/CT was significantly higher than that observed by CT alone (P = 0.022), especially in infiltrative soft tissue and serosal locations.

Conclusions
This small pilot trial suggests a role for 68Ga-FAPI PET/CT in ILC, which needs to be confirmed by subsequent trials.
Diagnostic value of plasma microbial cell-free DNA sequencing in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis
Authors: Degner Nicholas , Vissichelli Nicole C. , Berman David M. , Smollin Matt , Morales Megan K. 
Published: January 2023

AbstractHematopoietic stem cell transplant (HSCT) recipients are at increased risk for a wide spectrum of infections, including opportunistic infections with atypical presentations. Diagnosis can be challenging and often requires extensive testing and invasive procedures. Sequencing of plasma microbial cell-free DNA (mcfDNA) allows non-invasive untargeted detections of human pathogens, making this modality appealing for this patient population.The purpose of this study was to perform a meta-analysis to evaluate the diagnostic value of sequencing of plasma mcfDNA for infections in HSCT recipients. We searched for relevant articles in BASE, PubMed, andClinicalTrials.govfrom January 1996 to November 2022. Studies were eligible for inclusion if they assessed the diagnostic performance of sequencing of plasma mcfDNA and included HSCT recipients with sufficient data to assign plasma mcfDNA test results as true positive, true negative, false positive, or false negative, which were used to calculate diagnostic test accuracy.A total of 6 studies and 69 patients were included. All included studies were published in 2019 or later and were conducted in the United States. Three studies were exclusively pediatric, two exclusively adult, and one a mixture of both adult and pediatric patients. The pooled sensitivity was 0.90 (95% CI 0.71-0.97) and the pooled specificity was 0.75 (0.49-0.90).The high pooled diagnostic odds ratio suggests that sequencing of plasma mcfDNA may have a unique diagnostic role in HSCT recipients. Its high sensitivity and capability to detect a broad array of pathogens makes it a promising adjunct to traditional diagnostic testing.
Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection
Authors: Skye Jax , Bruss Joel , Toescu Sebastian , Aquilina Kristian , Lola Gino Bardi , Boes Aaron D. 
Published: January 2023

AbstractBackground and ObjectivesApproximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome (CMS). Our group recently showed that damage to the cerebellar outflow pathway is associated with increased risk of CMS. Here, we tested whether these findings replicate in an independent cohort.MethodsWe evaluated the relationship between lesion location and the development of CMS in an observational study of 56 pediatric patients who underwent cerebellar tumor resection. We hypothesized that individuals that developed CMS after surgery (CMS+), relative to those that did not (CMS-) would have lesions that preferentially intersected with: 1) the cerebellar outflow pathway, and 2) a previously generated ‘lesion-symptom map’ of CMS. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods (https://osf.io/r8yjv/).ResultsWe found supporting evidence for both hypotheses. Compared with CMS-patients, CMS+ patients (n=10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen’s d=.73, p=.05), and the CMS lesion-symptom map (Cohen’s d=1.1, p=.004).DiscussionThese results strengthen the association of lesion location with risk of developing CMS and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to pediatric cerebellar tumors.
Pre-analytical variables influence zinc measurement in blood samples
Authors: Killilea David W. , Schultz Kathleen 
Published: January 2023

AbstractZinc deficiency continues to be a major concern for global public health. The zinc status of a target population is typically estimated by measuring circulating zinc levels, but the sampling procedures are not standardized and thus may result in analytical discrepancies. To examine this, we designed a study that controlled most of the technical parameters in order to focus on five pre-analytical variables reported to influence the measurement of zinc in blood samples, including (1) blood draw site (capillary or venous), (2) blood sample matrix (plasma or serum), (3) blood collection tube manufacturer (Becton, Dickinson and Company or Sarstedt AG & Co), (4) blood processing time (0, 4, or 24 hours), and (5) blood holding temperatures (4°C, 20°C, or 37°C). A diverse cohort of 60 healthy adults were recruited to provide sequential capillary and venous blood samples, which were carefully processed under a single chain of custody and measured for zinc content using inductively coupled plasma optical emission spectrometry. When comparing blood draw sites, the mean zinc content of capillary samples was 0.051 mg/L (8%) higher than venous blood from the same donors. When comparing blood sample matrices, the mean zinc content of serum samples was 0.034 mg/L (5%) higher than plasma samples from the same donors. When comparing blood collection tube manufacturer, the mean zinc content from venous blood samples did not differ between venders, but the mean zinc content from BD capillary plasma was 0.036 mg/L (6%) higher than Sarstedt capillary plasma from the same donors. When comparing processing times, the mean zinc content of plasma and serum samples was 5-12% higher in samples processed 4-24 hour after collection. When comparing holding temperatures, the mean zinc content of plasma and serum samples was 0.5-7% higher in samples temporarily held at 20°C or 37°C after collection. Thus even with the same donors and blood draws, significant differences in zinc content were observed with different draw sites, tube types, and processing procedures, demonstrating that key pre-analytic variables can have an impact on zinc measurement, and subsequent classification of zinc status. Minimizing these pre-analytical variables is important for generating best practice guidelines for assessment of zinc status.