bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remembering America Without Remembering Women
Authors: Hasday Jill Elaine 
Published: January 2025

Abstract
Remembering America Without Remembering Women ties the judicial tendency to ignore women’s mobilization to persistent gaps in the nation’s collective memory. Commemorations weave stories about the nation through memorable occasions and everyday life. But America’s commemorative landscape too often leaves women out, and there has been too little improvement over time. Our cultural habit of thinking about women’s treatment as a product of consensus rather than conflict can tempt us to blame inertia for the gendered lopsidedness of America’s commemorations. That would miss the deliberate forces at work. From the start, women have endeavored to add their struggles for equality to America’s dominant stories about itself. Women have linked their activism to foundational expressions and symbols of American democratic ideals, like the Declaration of Independence and the Statue of Liberty. Women have sought to teach Americans about women’s history. Yet efforts to focus public memory on women—whether with monuments, museums, currency redesign, or otherwise—have repeatedly faced bitter and protracted opposition, for generations and to the present day. Struggles over commemorating women have often attracted less attention than they deserve. These battles rage nonetheless because they revolve around how to understand women’s place in the nation’s past, present, and future.
Supporting endocrine therapy adherence in women with breast cancer: findings from the ROSETA pilot fractional factorial randomized trial
Authors: Smith Samuel G , Green Sophie M C , McNaught Emma , Graham Christopher D , Foy Robbie , Ow Pei Loo , French David P , Hall Louise H , Wilkes Hollie , Taylor, BA Christopher , Ellison Rachel , Raine Erin , Walwyn Rebecca , Howdon Daniel , Clark Jane , Rousseau Nikki , Buxton, BA Jacqueline , Moore Sally J L , Waller Jo , Parbutt Catherine , Velikova Galina , Farrin Amanda , Collinson Michelle 
Published: January 2025

Abstract

Background
Adherence to adjuvant endocrine therapy (AET) in women with breast cancer is poor. Multicomponent intervention packages are needed to address adherence barriers. Optimizing these packages prior to definitive evaluation can increase their effectiveness, affordability, scalability, and efficiency.

Purpose
To pilot procedures for an optimization-randomized controlled trial (O-RCT) of the 'Refining and Optimizing Strategies to support Endocrine Therapy Adherence' (ROSETA) intervention.

Methods
This was a multisite individually randomized external pilot trial using a 24-1 fractional factorial design (ISRCTN10487576). Breast cancer survivors prescribed AET were recruited from 5 hospitals and randomized to one of 8 conditions, each comprising a combination of 4 intervention components set to “on” or “off” (SMS messages, information leaflet, guided self-help, and self-management website). We set criteria to inform the decision to progress to an O-RCT for consent rate, component adherence, and availability of outcome measures, with predefined cutoffs for “green” (proceed), “amber” (minor changes), and “red” (major changes).

Results
Among 141 eligible patients, 54 (38.3%) consented (green range). At least 50.0% of participants adhered to the minimum threshold set for each intervention component (green range). Data for one of the 3 medication adherence measures were available (amber range). Most (86.8%) participants were satisfied with their trial experience. Exploratory analysis indicated some evidence of a negative main effect of the information leaflet on medication adherence (adjusted mean difference = 0.088, 95% CI, 0.018, 0.158).

Conclusions
Progression to a fully powered O-RCT of the ROSETA intervention package is feasible, but review of medication adherence measures is required.
Revealing trends in measles immunity during periods of varying measles circulation in Madagascar
Authors: Menezes Arthur , Hay James A , Razafindratsimandresy Richter , Randriamanantena Andriamasina Herivelo , Yang Luojun , Héraud Jean-Michel , Cauchemez Simon , Wesolowski Amy , Grenfell Bryan , Graham Andrea L , Metcalf C Jessica E 
Published: January 2025

Abstract
Estimating the durability of immunity from vaccination is complicated by unreported re-vaccination, and unobserved natural infection or reexposure, which could result in overestimation of protection longevity. We tested serial cross-sectional serum samples from 2005 to 2015 (N=2,530) for IgG to examine measles seroprevalence, spatiotemporal patterns of titers across regions and antibody dynamics among children aged 1-9 years who grew up during varying measles circulation in Madagascar under a one-dose vaccination schedule. We found that measles seroprevalence has generally decreased over this time period. Furthermore, we conducted two nested serological surveys, analyzing 393 samples taken in 2005 (N=158), a time-point preceded by high levels of measles circulation, and 2015 (N=235), a time-point preceded by low levels of measles circulation. Among children alive during periods of limited measles circulation, we found lower measles seroprevalence in all age groups and lower antibody titers in children aged 7-9 years old. Notably, titers among children aged 7-9 dipped near the threshold of protection, highlighting the importance of additional measles vaccine doses. Our findings suggest that vulnerabilities might emerge during periods of limited measles circulation for countries with a one-dose schedule due to both the build-up of susceptible individuals and waning titers.
Continual Versus Occasional Blood Pressure (COOL-BP) in Remote Hypertension Management
Authors: Unlu Ozan , Cannon Christopher P , Lee Simin , Gabovitch Daniel , Zelle David , Chin Nicholas , Figueroa Christian , Collins Emma , Ruggiero Ryan , Almeida Tiago P , Perruchoud David , Sola Josep , Scirica Benjamin M , Fisher Naomi D L 
Published: January 2025

Abstract

BACKGROUND
Remote hypertension management programs have emerged as potential solutions to improve poor rates of blood pressure (BP) control. The Continual Versus Occasional Blood Pressure (COOL-BP) Study investigated the feasibility and efficacy of using a cuffless wrist BP monitor in a remote hypertension (HTN) program.

METHODS
COOL-BP was a prospective single-arm study within a larger HTN management program at Mass General Brigham (MGB). Participants had uncontrolled HTN, were already engaged in the MGB Remote Hypertension Program, and used a smartphone. The study involved patients wearing the Aktiia cuffless wrist BP monitor and performing traditional home BP monitoring (HBPM). The primary endpoint was the correlation of BP measurements between devices. Secondary endpoints included concordance between HBPM and cuffless pressures following a medication titration, and patient satisfaction with the cuffless device.

RESULTS
We enrolled 38 patients, of whom 25 provided BP data on overlapping dates with both devices. There was moderate correlation between average nonsimultaneous daytime BPs within the same time periods (r = 0.57, 95% CI: 0.39–0.71 for systolic BP [P &lt; 0.001]; r = 0.64, 95% CI: 0.48–0.76, for diastolic BP [P &lt; 0.001]). The concordance of systolic BP changes detected by the two devices post medication titration was 87.5%. Most patients (91%) preferred the cuffless device, citing ease of use and convenience.

CONCLUSIONS
Cuffless BP devices demonstrate promise in enhancing patient compliance and effectiveness in HTN management. Their integration into clinical practice could offer a more patient-friendly and reliable approach to BP monitoring, though more research is needed to establish their utility in large populations.
Galactocele Following Aesthetic Breast Augmentation: Diagnosis, Management, and Prevention
Authors: El Hajj Hiba , Eid Dollen , Tohme Roland , Sleilati Fadi 
Published: January 2025

Abstract

Galactorrhea and galactocele are rare complications following breast augmentation. These conditions can lead to significant patient discomfort and require careful management. This article aims to report 3 cases of galactocele that developed after aesthetic breast augmentation, proposing approaches for diagnosis, management, and prevention of galactocele. Three patients who underwent breast augmentation presented with galactocele. Clinical evaluations included aspiration of fluid collections, imaging studies, and laboratory tests to rule out infections and hormonal imbalances. Surgical interventions were tailored to each case based on patient preferences and clinical findings. In Case 1, a 40-year-old female experienced bilateral swelling 1-month postsurgery. Despite aspiration, symptoms recurred, leading to surgical revision and drainage. The implants were removed at her request. In Case 2, a 37-year-old female developed a unilateral galactocele 3 months postaugmentation after starting Norethisterone. Ultrasound-guided aspiration and surgical drainage were performed, with the implants kept in place. In Case 3, a 36-year-old female presented with wound dehiscence and lactescent discharge 7 months postaugmentation. Emergency surgery was needed for fluid evacuation, but worsening symptoms led to implant removal and drainage of bilateral galactoceles. Effective management of galactocele and galactorrhea postbreast augmentation requires a personalized approach, addressing both clinical presentations and patient-specific factors. Further awareness of these complications is essential for optimizing patient outcomes.

Level of Evidence: 5 (Diagnostic)
Is More Always Better? A Randomized Comparative Clinical Trial About the Impact of Polydioxanone Threads Quantity for Facial Lifting
Authors: Germani Marcelo , Munoz-Lora Victor R M , Carnevali Ana C N , Geroldo Adriana Marques , Teixeira Fernanda Fogolin , Giro Gabriela 
Published: January 2025

Abstract

Background
Minimally invasive aesthetic procedures, such as the use of polydioxanone (PDO) threads, are increasingly popular for facial rejuvenation.

Objectives
This study investigates the impact of the number of PDO threads on tissue displacement, volume changes, and patient satisfaction.

Methods
This randomized controlled trial involved 22 patients seeking facial lifting using PDO threads. Participants were divided into 2 groups: G1 with 3 threads per hemiface and G2 with 6 threads per hemiface. Three-dimensional stereophotogrammetry was used to evaluate volumetric changes and tissue displacement at baseline, 20 days, and 60 days posttreatment. Patient satisfaction was assessed using the Global Aesthetic Improvement Scale (GAIS).

Results
Significant volumetric changes were observed over time in both midface and lower face regions (P &lt; .05), but no significant intergroup differences were found (P &gt; .6). Tissue displacement showed statistical significance over time (P = .039) but not between groups (P = .821). GAIS scores did not differ significantly between groups or between patients and specialists. Adverse events were minor and transient, primarily involving pain.

Conclusions
The number of PDO threads used did not significantly influence sustained lifting outcomes or patient satisfaction. Initial improvements in volume and tissue displacement diminished by 60 days, suggesting that additional threads do not enhance long-term efficacy. Further studies with longer follow-up are needed to better understand collagen stimulation’s potential role in lasting effects.

Level of Evidence: 2 (Therapeutic)
Sphae: an automated toolkit for predicting phage therapy candidates from sequencing data
Authors: Papudeshi Bhavya , Roach Michael J , Mallawaarachchi Vijini , Bouras George , Grigson Susanna R , Giles Sarah K , Harker Clarice M , Hutton Abbey L K , Tarasenko Anita , Inglis Laura K , Vega Alejandro A , Souza Cole , Boling Lance , Hajama Hamza , Cobián Güemes Ana Georgina , Segall Anca M , Dinsdale Elizabeth A , Edwards Robert A 
Published: January 2025

Abstract

Motivation
Phage therapy offers a viable alternative for bacterial infections amid rising antimicrobial resistance. Its success relies on selecting safe and effective phage candidates that require comprehensive genomic screening to identify potential risks. However, this process is often labor intensive and time-consuming, hindering rapid clinical deployment.

Results
We developed Sphae, an automated bioinformatics pipeline designed to streamline the therapeutic potential of a phage in under 10 minutes. Using Snakemake workflow manager, Sphae integrates tools for quality control, assembly, genome assessment, and annotation tailored specifically for phage biology. Sphae automates the detection of key genomic markers, including virulence factors, antimicrobial resistance genes, and lysogeny indicators such as integrase, recombinase, and transposase, which could preclude therapeutic use. Among the 65 phage sequences analyzed, 28 showed therapeutic potential, 8 failed due to low sequencing depth, 22 contained prophage or virulent markers, and 23 had multiple phage genomes. This workflow produces a report to assess phage safety and therapy suitability quickly. Sphae is scalable and portable, facilitating efficient deployment across most high-performance computing and cloud platforms, accelerating the genomic evaluation process.

Availability and implementation
Sphae source code is freely available at https://github.com/linsalrob/sphae, with installation supported on Conda, PyPi, Docker containers.
Organ-specific malperfusion in acute type A aortic dissection: epidemiological meta-analysis of incidence rates
Authors: Chandiramani Ashwini , Al-Tawil Mohammed , Elleithy Assem , Kakar Sahil , Rajasekar Tharun , Panda Abinash , Sabry Haytham , Haneya Assad , Harky Amer 
Published: January 2025

Abstract

Background
Acute type A aortic dissection is a life-threatening clinical emergency that necessitates immediate surgical intervention with an estimated mortality rate of approximately 1–2% per hour. When complicated by malperfusion, the perioperative mortality rate is reported to be increased by up to 39%. Malperfusion can affect many vascular beds with varying incidence and severity, resulting in coronary, cerebral, visceral, peripheral, renal or spinal malperfusion. The primary aim of this systematic review and meta-analysis is to investigate the epidemiology of specific types of organ malperfusion in acute type A aortic dissection and to analyse the impact on the survival outcomes associated with each malperfusion type.

Methods
Electronic databases PubMed, MEDLINE and Embase were searched through to September 2024 to identify original studies that presented data on the incidence and the survival outcome of organ malperfusion in association with acute type A aortic dissection. The extracted data included patient characteristics and incidence of organ-specific malperfusion. Primary outcomes were the respective in-hospital mortality rate associated with each organ-specific malperfusion and a proportional meta-analysis was conducted to pool results. Quality assessment was performed using the modified National Institutes of Health quality assessment tool for single-arm observational studies.

Results
A total of 40 studies met the inclusion criteria, including a total of 35 361 patients. Peripheral limb malperfusion was the most prevalent with a pooled incidence of 12% (95% c.i. 10 to 14). This was followed by lower limb or iliofemoral with 11% (95% c.i. 9 to 14). Spinal malperfusion was the lowest with 1% (95% c.i. 1 to 2). The pooled mortality rate with organ malperfusion varied between 18 and 36%. Within this population the highest mortality rate was associated with mesenteric malperfusion with 36% (95% c.i. 28 to 45). Following this the highest mortality rate was found with coronary at 33% (95% c.i. 26 to 40) and cerebral at 28% (95% c.i. 24 to 33) malperfusion.

Conclusion
Survival during hospital admission after acute type A aortic dissection can vary depending on the presence and type of malperfusion, with mesenteric, coronary and cerebral malperfusion being associated with the highest in-hospital mortality rates. Organ-specific malperfusion syndromes should be considered when assessing the perioperative risk and surgical planning of patients undergoing surgical repair for acute type A aortic dissection.
Synthesis of multisubstituted naphthalenes through consecutive aryne reactions
Authors: Tanaka Takanori , Tabata Shinya , Nakamura Keisuke , Hazama Yuki , Sakata Yuki , Hosoya Takamitsu , Yoshida Suguru 
Published: January 2025

Abstract
Consecutive aryne reactions using naphthodiyne equivalents are disclosed. Selective naphthalyne generations were achieved by selective activation of the silyl or iodo group in a reagent controlled manner. By virtue of the divergence in transformations of aryne intermediates, a wide variety of molecules that contain a naphthalene core were synthesized from simple modules by the consecutive aryne reactions.
Unsupervised clustering of intra-ventricular haemodynamic forces for the phenotyping of left ventricular function in non-ischaemic left ventricular cardiomyopathy
Authors: Airale Lorenzo , Giustiniani Alessandro , Ródenas-Alesina Eduard , Lozano-Torres Jordi , Escribano-Escribano Pablo , Vila-Olives Rosa , Tobias-Castillo Pablo Eduardo , Calvo-Barceló Maria , Badia-Molins Clara , Cesareo Marco , Lopez-Gutierrez Pere , Ferreira-Gonzalez Ignacio , Milan Alberto , Rodriguez-Palomares Jose , Guala Andrea 
Published: January 2025

Abstract

Aims
Cardiac magnetic resonance (CMR) is essential for diagnosing cardiomyopathy, serving as the gold standard for assessing heart chamber volumes and tissue characterization. Haemodynamic forces (HDFs) analysis, a novel approach using standard cine CMR images, estimates energy exchange between the left ventricular (LV) wall and blood. While prior research has focused on peak or mean longitudinal HDF values, this study aims to investigate whether unsupervised clustering of HDF curves can identify clinically significant patterns and stratify cardiovascular (CV) risk in non-ischaemic LV cardiomyopathy (NILVC).

Methods and results
A retrospective cohort of 279 patients with NILVC who underwent cardiac CMR at Vall d’Hebron University Hospital (Barcelona) was examined. Unsupervised clustering of longitudinal and transversal HDF curves was performed using dynamic time warping for dissimilarity measurement and the partitioning around medoids algorithm. Outcomes were defined as a composite of CV mortality, heart failure hospitalization, and ventricular arrhythmias. The median age was 65 (57.0; 74.0) years, with 27.2% females and 35.5% showing late gadolinium enhancement (LGE). Unsupervised clustering identified three distinct clusters, delineating risk groups with worsening LA and LV function, indicating a stepwise increase in CV risk profile. Over a median follow-up of 40 months, 60 patients experienced the composite outcome. After adjusting for LGE, LV ejection fraction (EF), and LV size, Clusters 2 and 3 demonstrated a significantly higher risk of adverse events (both P &lt; 0.05) compared with Cluster 1.

Conclusion
Analysing both longitudinal and transversal HDFs throughout the cardiac cycle enables the identification of distinct phenotypes with prognostic value beyond EF and LGE in NILVC patients.
Comprehensive transthoracic echocardiographic evaluation of doxorubicin-induced cardiotoxicity: a multimodal imaging approach in an animal model
Authors: Haesen Sibren , Steegen Lisa , Deluyker Dorien , Bito Virginie 
Published: January 2025

Abstract

Aims
Anthracycline-induced cardiotoxicity has high incidence rates and causes significant mortality among cancer survivors. Damage to myocardial tissue leads to left ventricular (LV) dilation with systolic dysfunction, typically assessed through echocardiographic measurement of LV ejection fraction (LVEF) and volumes. Early detection is crucial for improving patient outcomes. We aimed to evaluate cardiotoxicity progression and diagnostic performance of different echocardiographic modalities in an animal model.

Methods and results
Female Sprague Dawley rats received either intravenous doxorubicin (DOX) injections weekly for 8 weeks (2 mg/kg/week) or saline (control). Transthoracic LV echocardiography was performed before treatment and at 4, 6, and 8 weeks in the treatment course. Two researchers performed and evaluated M-mode, B-mode, and four-dimensional (4D) echocardiography. Bland–Altman plots were created to show the bias and limits of agreement when comparing echocardiographic modalities. Simple linear regression and Pearson correlation were applied to evaluate interobserver variability. Six weeks after the first DOX injection, LVEF, radial LV fractional shortening, LV end-systolic volume, and LV end-diastolic volume were significantly reduced compared with baseline. LV dysfunction and dilation became more pronounced after 8 weeks of DOX treatment. For all parameters, 4D- and M-mode showed the lowest bias and narrowest limits of agreement. The correlation between the researchers’ measurements was strong for most parameters.

Conclusion
Our rat model of DOX-induced cardiotoxicity demonstrates that volumetric changes are more pronounced. Both 4D- and M-mode imaging techniques proved effective and reliable compared with the standard B-mode approach, with minimal interobserver variability, indicating strong reproducibility.
Corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis stratified by left ventricular ejection fraction
Authors: Segawa Takatsugu , Taniguchi Tatsunori , Nabeta Takeru , Naruse Yoshihisa , Kitai Takeshi , Yoshioka Kenji , Tanaka Hidekazu , Okumura Takahiro , Baba Yuichi , Matsue Yuya , Sakata Yasushi 
Published: January 2025

Abstract

Aims
This study aimed to investigate the relationship between corticosteroid therapy and long-term outcomes in patients with cardiac sarcoidosis, stratified by left ventricular ejection fraction (LVEF) at diagnosis.

Methods and results
This study conducted a post hoc analysis of the ILLUstration of the Management and prognosIs of JapaNese PATiEnts with Cardiac Sarcoidosis, a retrospective multicentre registry. Cardiac sarcoidosis was diagnosed based on the 2016 Japanese Circulation Society and 2014 Heart Rhythm Society criteria. The primary endpoint was a composite of all-cause death, hospitalization for heart failure, and fatal ventricular arrhythmia events. Patients were divided into three groups based on LVEF: preserved LVEF (≥50%, n = 251), moderately impaired LVEF (LVEF, 35–49%; n = 149), and severely impaired LVEF (&lt;35%, n = 99). Among 499 patients with cardiac sarcoidosis (mean age: 61.6 ± 11.4 years, male: 36.1%), 419 (84.0%) were treated with corticosteroids after diagnosis. During a median follow-up of 33.7 months (interquartile range, 16.8–62.7 months), 144 primary endpoints (28.9%) occurred. Corticosteroid therapy was associated with better prognosis when assessed in terms of primary endpoint in the entire cohort [hazard ratio (HR) 0.61, 95% confidence interval (CI) 0.41–0.89, P = 0.010]. When stratified by LVEF, corticosteroid therapy was significantly associated with a lower incidence of primary endpoints in the preserved LVEF group (HR, 0.30; 95% CI, 0.15–0.57, P &lt; 0.001), but not in the moderately and severely impaired LVEF groups. This association remained robust, even after adjusting for confounders.

Conclusion
In this large cohort of cardiac sarcoidosis, corticosteroid therapy was associated with a lower incidence of long-term outcomes only in patients with preserved LVEF at diagnosis.

Clinical Trial Registration
UMIN000034974.