bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatiotemporal electrogram dispersion ablation targeting rotors is more effective for elderly patients than non‐elderly population
Authors: Sakata Kensuke , Tanaka Tomomi , Yamashita Soichiro , Kobayashi Masanori , Ito Mitsuaki , Yamashiro Kohei 
Published: May 2023

AbstractBackgroundModulating atrial fibrillation (AF) drivers has been proposed as one of the effective ablation strategies for non‐paroxysmal AF (non‐PAF). However, the optimal non‐PAF ablation strategy is still under debate because the exact mechanisms of AF persistence including focal activity and/or rotational activity, are not well‐understood. Recently, spatiotemporal electrogram dispersion (STED) assumed to indicate rotors in the form of rotational activity is proposed as an effective target for non‐PAF ablation. We aimed to clarify the effectiveness of STED ablation for modulating AF drivers.MethodsSTED ablation plus pulmonary vein isolation was applied in 161 consecutive non‐PAF patients not undergoing previous ablation. STED areas within the entire left and right atria were identified and ablated during AF. After the procedures, the STED ablation's acute and long‐term outcomes were investigated.Results(1) Despite a more effective acute outcome of the STED ablation for both AF termination and non‐inducibility of atrial tachyarrhythmias (ATAs), Kaplan–Meier curves showed that the 24‐month freedom ratio from ATAs was 49%, which resulted from the higher recurrence ratio of atrial tachycardia (AT) rather than AF. (2) A multivariate analysis showed that the determinant of ATA recurrences was only a non‐elderly age, not long‐standing persistent AF, and an enlarged left atrium, which were conventionally considered as key factors.ConclusionsSTED ablation targeting rotors was effective in elderly non‐PAF patients. Therefore, the main mechanism of AF persistency and the component of the fibrillatory conduction might vary between elders and non‐elders. However, we should be careful about post‐ablation ATs following substrate modification.
Inter‐joint coordination variability is associated with pain severity and joint loading in persons with knee osteoarthritis
Authors: Huang Chun‐Hao , James Khara , Lanois Corey , Corrigan Patrick , Yen Sheng‐Che , Stefanik Joshua 
Published: May 2023

AbstractAs the lower extremity is a linked‐joint system, the contribution of movements at the hip and ankle, in addition to the knee, to gait patterns should be considered for persons with knee osteoarthritis (OA). However, the relationships of joint coordination variability to OA symptoms, particularly knee pain, and joint loading is unknown. The purpose of this study was to determine the relationship of joint coordination variability to knee pain severity and joint loading in persons with knee OA. Thirty‐four participants with knee OA underwent gait analysis. Vector coding was used to assess coordination variability during the early, mid, and late stance phase. Hip–knee coupling angle variability (CAV) during midstance was associated with Knee Injury and Osteoarthritis Outcome Score (KOOS) pain (r = −0.50, p = 0.002) and Visual Analog Scale pain (r = 0.36, p = 0.04). Knee–ankle CAV during midstance was associated with KOOS pain (r = −0.34, p = 0.05). Hip–knee CAV during early and midstance were associated with knee flexion moment (KFM) impulses (r = −0.46, p = 0.01). Knee–ankle CAV during early and midstance were associated with peak KFM (r = −0.51, p < 0.01; r = −0.70, p < 0.01). Moreover, knee–ankle CAV during early, mid, and late stance phase were associated with KFM impulses (r = −0.53, p < 0.01; r = −0.70, p < 0.01; r = −0.54, p < 0.01). These findings suggest that joint coordination variability may be a factor that influences pain and knee joint loading in persons with knee OA. Statement of Clinical Significance: Movement coordination of the hip, knee, and ankle should be considered in the clinical management and future research related to knee OA.
Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling
Authors: Wang Huan , Zhang Weidong , Cai Yan , Guo Qianping , Pan Liangbin , Chu Genglei , Chen Jianquan , Yuan Zhangqin , Li Bin 
Published: May 2023

AbstractIntervertebral disc degeneration (IDD) is a leading cause of low back pain. The inflammatory responses caused by aberrant mechanical loading are one of the major factors leading to annulus fibrosus (AF) degeneration and IDD. Previous studies have suggested that moderate cyclic tensile strain (CTS) can regulate anti‐inflammatory activities of AF cells (AFCs), and Yes‐associated protein (YAP) as a mechanosensitive coactivator senses diverse types of biomechanical stimuli and translates them into biochemical signals controlling cell behaviors. However, it remains poorly understood whether and how YAP mediates the effect of mechanical stimuli on AFCs. In this study, we aimed to investigate the exact effects of different CTS on AFCs as well as the role of YAP signaling involving in it. Our results found that 5% CTS inhibited the inflammatory response and promoted cell growth through inhibiting the phosphorylation of YAP and nuclear localization of NF‐κB, while 12% CTS had a significant proinflammatory effect with the inactivation of YAP activity and the activation of NF‐κB signaling in AFCs. Furthermore, moderate mechanical stimulation may alleviate the inflammatory reaction of intervertebral discs through YAP‐mediated suppression of NF‐κB signaling in vivo. Therefore, moderate mechanical stimulation may serve as a promising therapeutic approach for the prevention and treatment of IDD.
Assessing the surveillance use of 2018 EFP/AAP classification of periodontitis: A validation study and clustering analysis
Authors: Du Mi , Mo Yuanqiu , Li An , Ge Shaohua , Peres Marco A. 
Published: May 2023

AbstractBackgroundThe performance of the 2018 European Federation of Periodontology/American Academy of Periodontology (EFP/AAP) classification of periodontitis for epidemiology surveillance purposes remains to be investigated. This study assessed the surveillance use of the 2018 EFP/AAP classification and its agreement with the unsupervised clustering method compared with the 2012 Centers for Disease Control and Prevention(CDC)/AAP case definition.MethodsParticipants (n = 9424) in the National Health and Nutrition Examination Survey (NHANES) were staged by the 2018 EFP/AAP classification and classified into subgroups via k‐medoids clustering. Concordance levels between periodontitis definitions and the clustering method were evaluated through the multiclass area under the receiver operating characteristic curve (multiclass AUC) among “periodontitis cases” and the general population, respectively. The multiclass AUC of the 2012 CDC/AAP definition versus clustering was used as a reference. The associations of periodontitis with chronic diseases were estimated using multivariable logistic regression.ResultsAll the participants were identified as “periodontitis cases” by the 2018 EFP/AAP classification, and the prevalence of stage III–IV was 30%. The optimal numbers of clusters were three and four. The 2012 CDC/AAP definition versus clustering yielded a multiclass AUC of 0.82 and 0.85 among the general population and “periodontitis cases,” respectively. The multiclass AUC of the 2018 EFP/AAP classification versus clustering was 0.77 and 0.78 for different target populations. Similar patterns prevailed in associations with chronic diseases between the 2018 EFP/AAP classification and clustering.ConclusionsThe validity of the 2018 EFP/AAP classification was verified by the unsupervised clustering method, which performed better in distinguishing “periodontitis cases” than classifying the general population. For surveillance purposes, the 2012 CDC/AAP definition showed a higher agreement level with the clustering method than the 2018 EFP/AAP classification.
Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorate cognitive dysfunction in AD mice induced by a combination of d‐gal and AlCl3 by suppressing oxidative stress and inflammation reaction
Authors: Zhao Hong , Liu Jiayue , Wang Yanyan , Shao Mengting , Wang Lihong , Tang Weiwei , Wang Yuliang , Li Xiaoliang 
Published: May 2023

AbstractBACKGROUNDThe therapeutic properties of Hippophae rhamnoides L. were known in Ancient Greece and in Tibetan and Mongolian medicine, which commonly used it for the treatment of heart ailments, rheumatism, and brain disorders. Modern studies have indicated that Hippophae rhamnoides L. polysaccharide (HRP) can improve cognitive impairment in mice with Alzheimer's disease (AD) but the specific mechanisms of the protective effect of HRP have not been elucidated fully.RESULTSOur results showed that Hippophae rhamnoides L. polysaccharide I (HRPI) improved pathological behaviors related to memory and cognition, and reduced 1Beta‐amyloid (Aβ) peptide deposition and neuronal cell necrosis. Pretreatment with Hippophae rhamnoides L. polysaccharide I (HRPI) also decreased the level of Toll‐like receptor 4 (TLR4) and Myeloid differentiation factor 88 (MyD88), and reduced the release of inflammatory factors Tumor necrosis factor alpha (TNFα) and interleukin 6 (IL‐6) in the brains of mice with AD. Treatment with HRPI also suppressed the expression level of Recombinant Kelch Like ECH Associated Protein 1 (KEAP1), and increased the levels of Nuclear factor erythroid 2‐Related Factor 2 (Nrf2), antioxidant enzymes Superoxide dismutase (SOD) and Glutathione peroxidase (GSH‐Px) in the brains of AD mice.CONCLUSIONSOn the whole, these findings revealed that HRPI could improve the learning and memory ability and attenuate pathologic impairment in AD mice, and the underlying mechanisms may involve mediating oxidative stress and inflammation, possibly through the regulation of the Keap1/Nrf2 and TLR4/MyD88 signaling pathways. © 2023 Society of Chemical Industry.
The effect of anastomotic leakage on the incidence of recurrence after tri‐modality therapy for esophageal adenocarcinomas
Authors: Stam Wessel T. , Schuring Nannet , Hulshof Maarten , van Laarhoven Hanneke , Derks Sarah , van Berge Henegouwen Mark I. , van der Peet Donald L. , Gisbertz Suzanne S. , Daams Freek 
Published: May 2023

AbstractBackgroundNeoadjuvant chemoradiotherapy (nCRTx) reduces the incidence of recurrence, while anastomotic leakage has shown increase the risk of recurrence. The primary objective of this retrospective study was to investigate the incidence and pattern of recurrence and secondary median recurrence‐free interval and post‐recurrence survival in patients with and without anastomotic leakage after multimodal therapy for esophageal adenocarcinoma.MethodsPatients with recurrence after multimodal therapy between 2010 and 2018 were included.ResultsSix hundred and eighteen patients were included, 91 (14.7%) had leakage and 278 (45.0%) recurrence. Patients with leakage did not develop recurrence more often (48.4%) than those without (44.4%, [p = 0.484]). Recurrence‐free interval for patients with (n = 44) and without leakage (n = 234) was 39 and 52 weeks, respectively (p = 0.049). Post‐recurrence survival was 11 and 16 weeks, respectively (p = 0.702). Specified by recurrence site, post‐recurrence survival for loco‐regional recurrences was 27 versus 33 weeks (p = 0.387) for patients with and without leakage, for distant 9 versus 13 (p = 0.999), and for combined 11 versus 18 weeks (p = 0.492).Conclusion and DiscussionNo higher incidence of recurrent disease was observed in patients with anastomotic leakage, however it is associated with a shorter recurrence‐free interval. This could have implications for surveillance, as early detection of recurrent disease could influence therapeutic options.
Amphiphilic polymers facilitated solid‐phase extraction coupled with ultra‐performance liquid chromatography‐tandem mass spectrometry for direct extraction and analysis of zearalenone and zearalanone in corn juice samples
Authors: Wu Zhuqiang , Jiang Xiangqiong , Yang Yanqun , Shi Rui , Ruan Guihua , Huang Yipeng 
Published: May 2023

In this work, amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions are demonstrated to be capable of direct extracting zearalenone and zearalanone in samples consisting of an oil‐water emulsion system. Under optimal conditions, the maximum adsorption capacities for zearalenone and zearalanone are 17.27 and 13.26 mg/g. The adsorption is mainly attributed to π‐π interaction, hydrophobic interaction, and hydrogen‐bonding interaction for zearalenone and zearalanone. The adsorption isotherms reveal that the adsorption of zearalenone and zearalanone on amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions follows Freundlich model with multilayer and heterogeneous adsorption due to the presence of multiple kinds of adsorption sites. The relative recoveries of the spiked zearalenone and zearalanone in corn juice samples range from 85% to 93% with relative standard deviations lower than 3.52%. The results manifest the high efficiency of amphiphilic polymers synthesized from carboxylated carbon nanotubes stabilized high internal phase emulsions for the adsorption and separation of analytes in the oil‐water emulsion system. This study provides a new perspective on adsorbent engineering for the adsorption application in heterogeneous media.
Decomposition reaction kinetics of double‐base propellant catalyzed with graphene oxide–copper oxide nanocomposite
Authors: Louafi Elamine , Boulkadid Moulai Karim , Belgacemi Raouf , Touidjine Sabri , Akbi Hamdane , Belkhiri Samir , Benaliouche Fouad 
Published: May 2023

AbstractThe purpose of this paper is the investigation of the catalytic effect of graphene oxide–copper oxide nanocomposite (GCNC) on the thermal comportment and decomposition reaction kinetics of a double‐base propellant (DBP) formulation. Differential scanning calorimetry (DSC) was used to conduct the thermal analysis. Using well‐known iso‐conversional kinetics methods, namely, Vyazovkin's nonlinear integral with compensatory effect (VYA/CE), Kissinger–Akahira–Sunose (KAS), and Flynn–Wall–Ozawa (FWO), the thermokinetic parameters for the investigated propellant, including activation energy and frequency factor, were estimated. Additionally, based on the results obtained from the kinetic analysis, the critical ignition temperature was calculated. The results showed that after the addition of GCNC, the activation energy barrier is lowered by 18%, and the critical ignition temperature is reduced.
Prediction of spring agricultural drought using machine learning algorithms in the southern Songnen Plain, China
Authors: Chen Xiuxue , Li Xiaofeng , Jiang Bo , Su Jiajia , Zheng Xingming , Wang Guangrui 
Published: May 2023

AbstractWinter climate conditions have a great effect on spring soil moisture (SM) in cold regions. The frequent occurrence of spring drought events in the Songnen Plain poses a significant threat to food security. In this study, we selected the random forest (RF) algorithm from three currently popular machine learning algorithms to predict the spatial pattern of average SM for the period of April 1–15 and April 16–30 with 1 km resolution in the dry cropland of southern Songnen Plain (SSNP) using 0–10 cm SM data for each April from 81 agro‐meteorological stations and winter climate data (e.g., temperature, snowfall), soil properties and topographic relief. Compared to the existing ERA5_Land and SMAP SM products, we obtain higher precision SM data (April 1–15: r = 0.74, RMSE = 0.050 m3 m−3; April 16–30: r = 0.73, RMSE = 0.051 m3 m−3). Drought grades were classified based on predicted SM data, and the results indicate agricultural drought was mainly influenced by the change of winter snowfall/snow depth, with western SSNP being more susceptible to drought because of soil properties. Compared with current SM data products, the RF model proposed in this study can implement more accurate prediction of spring soil drought based on winter climate, provide important information for agricultural management departments to prepare for spring cropping and irrigation, and avoid further soil salinization caused by drought.
Formulation and tribological performance of engine oil blended with various non‐edible vegetable oils
Authors: Basiron Juliana , Abdollah Mohd Fadzli Bin , Abdullah Muhammad Ilman Hakimi Chua , Amiruddin Hilmi 
Published: May 2023

AbstractThis present study formulated eco‐friendly lubricants by combining non‐edible vegetable oils with a mineral oil and investigated their efficacy on the friction and wear characteristics of four AISI 52100 chrome steel balls. Multiple formulations containing varying combinations of 0 to 100 vol% of a mineral oil SAE 15W40 (S100), castor oil (C100), and jatropha oil (J100) were prepared using the sonification technique in an ultrasonic homogeniser. A fourier transform spectrometer (FTIR) was then used to investigate the molecular vibrations of each formulation. A tribological test was also performed with a four‐ball tribometer according to ASTM D4172‐94 engineering standards. Finally, a scanning electron microscope (SEM) equipped with an energy dispersive X‐ray spectroscope (EDX) was used to examine surface morphologies. The 80% S100, 10% C100, and 10% J100 (S80C10J10) formulation provided excellent tribological performance as it contained fatty acids composed of carbohydrates and carbonyl groups, particularly polysaccharides and glycerols.
Translation, cross‐cultural adaptation and evaluation of the Iranian Persian version of student survey on writing nursing care plan
Authors: Ramazanzadeh Nargess , Ghahramanian Akram , Zamanzadeh Vahid , Onyeka Tonia C. , Valizadeh Leila , Ghaffarifar Saeideh 
Published: May 2023

AbstractAimThe objective of this study was to validate the Iranian translation and cross‐cultural adaptation of the Student Survey on Writing Nursing Care Plan (SSW‐NCP).BackgroundTo provide supporting evidence about the nursing students' skill in planning and documenting nursing care plans based on nursing process, Salvador et al. developed the SSW‐NCP to measure the extent to which nursing students are qualified in writing nursing care plans. However, an Iranian version of the SSW‐NCP is presently not available.MethodThe cross‐cultural adaptation and linguistic translation of the SSW‐NCP adhered to World Health Organization (WHO) guidelines. The reliability and validity process followed the COSMIN checklist.ResultsThe survey was well translated to Persian language and culturally adapted through confirming the relevancy, appropriateness and logical representation of all aspects on nursing process by bilingual experts and pre‐tested on Persian‐speaking nursing students. The Cronbach's Alpha coefficient (α) and test–retest stability assessing affirmed the reliability, and convergent validity of the adapted survey was confirmed through comparison to Influencing Factors of Nursing Students' Clinical Judgment (IFNSCJ). The adaptation process of the SSW‐NCP resulted in a conceptually equivalent translated version, which is comparable to the original version and is acceptably valid and reliable.Implications for Nursing ManagementKnowing the proficiency of nursing students as future nurses in writing nursing care plans can provide accurate professional information for better educational and practical level programming and management that can enhance nursing practice.Patient or Public ContributionThe target group of survey was nursing students who contributed and participated in the current study.
Toxicity and feasibility of vincristine, etoposide, and carboplatin alternating with vincristine, doxorubicin, and cyclophosphamide in children with advanced retinoblastoma in Guatemala
Authors: Graff Zachary , Giron Veronica , Miller Kristen , Pixtun Dyna , Alejos Amanda , Luna‐Fineman Sandra 
Published: May 2023

AbstractRetinoblastoma is highly curable, with event‐free survival (EFS) of greater than 95% in high‐income countries. However, in lower middle‐income countries, outcomes of EFS are 30%–60% due to delayed diagnosis and lack of resources resulting in extra‐ocular disease. We report the toxicity profile and outcomes of intensified therapy for advanced retinoblastoma: vincristine, etoposide, carboplatin (VEC) alternating with vincristine, doxorubicin, and cyclophosphamide (VDoCx) in Guatemala. Compared to VEC alone, similar rates of neutropenia, anemia, and thrombocytopenia were seen, with no toxic deaths. Although survival was not a primary objective, a modest survival benefit supports further investigation of VEC+VDoCx for advanced retinoblastoma.
Mechanical and fracture properties of carbon nano fibers/short carbon fiber epoxy composites
Authors: Nimbagal Vijayakumar , Banapurmath N. R. , Umarfarooq M. A. , Revankar Suraj , Sajjan Ashok M. , Soudagar Manzoore Elahi M. , Shahapurkar Kiran , Alamir Mohammed A. , Alarifi Ibrahim M. , Elfasakhany Ashraf 
Published: May 2023

AbstractThis work investigated the influence of carbon nanofibers (CNFs) and aggregate of CNFs with micro‐sized short carbon fibers (SCFs) on the mechanical, thermal, and fracture properties of epoxy (80%) ‐ Polylactic acid (PLA) (20%) composite. Epoxy‐PLA composite loaded with CNFs (0.2, 0.3, and 0.4 wt.%) and a combination of CNFs and SCFs (0.2 and 0.4 wt.% with equal content of each filler) were manufactured by sonication and manual casting. The synergistic effects of CNFs and SCFs in the epoxy matrix were investigated through mechanical and fracture characterization of nanocomposites. In comparison to CNF‐reinforced nanocomposites, the composites reinforced with integrated multiscale fillers have higher tensile, flexural, impact strength, and fracture toughness. Tensile, flexural and impact strength increased by 17.18–25.72%, 39.24–44.07%, and 39.87–97.05% respectively with the incorporation of both CNFs and SCFs into epoxy‐PLA matrices. An improvement in fracture toughness in the range of 37.93–38.77% was observed in hybrid nanocomposites in comparison to pristine epoxy‐PLA composite. The synergetic mechanism of nano and micro fillers was studied by using the fracture surfaces from tensile tests using scanning electron microscopy. The numerical analysis was also carried out to simulate the effects of filler concentration on the tensile and bending strength of nanocomposites through representative volume element using an ANSYS workbench.