bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inferring the impact of feedback on the matter distribution using the Sunyaev Zel’dovich effect: insights from CAMELS simulations and ACT + DES data
Authors: Pandey Shivam , Lehman Kai , Baxter Eric J , Ni Yueying , Anglés-Alcázar Daniel , Genel Shy , Villaescusa-Navarro Francisco , Delgado Ana Maria , di Matteo Tiziana 
Published: July 2023

ABSTRACT
Feedback from active galactic nuclei and stellar processes changes the matter distribution on small scales, leading to significant systematic uncertainty in weak lensing constraints on cosmology. We investigate how the observable properties of group-scale haloes can constrain feedback’s impact on the matter distribution using Cosmology and Astrophysics with MachinE Learning Simulations (CAMELS). Extending the results of previous work to smaller halo masses and higher wavenumber, k, we find that the baryon fraction in haloes contains significant information about the impact of feedback on the matter power spectrum. We explore how the thermal Sunyaev Zel’dovich (tSZ) signal from group-scale haloes contains similar information. Using recent Dark Energy Survey weak lensing and Atacama Cosmology Telescope tSZ cross-correlation measurements and models trained on CAMELS, we obtain 10 per cent constraints on feedback effects on the power spectrum at $k \sim 5\, h\, {\rm Mpc}^{-1}$. We show that with future surveys, it will be possible to constrain baryonic effects on the power spectrum to $\mathcal {O}(\lt 1~{{\ \rm per\ cent}})$ at $k = 1\, h\, {\rm Mpc}^{-1}$ and $\mathcal {O}(3~{{\ \rm per\ cent}})$ at $k = 5\, h\, {\rm Mpc}^{-1}$ using the methods that we introduce here. Finally, we investigate the impact of feedback on the matter bispectrum, finding that tSZ observables are highly informative in this case.
STE20‐type kinases MST3 and MST4 promote the progression of hepatocellular carcinoma: Evidence from human cell culture and expression profiling of liver biopsies
Authors: Caputo Mara , Xia Ying , Anand Sumit Kumar , Cansby Emmelie , Andersson Emma , Marschall Hanns‐Ulrich , Königsrainer Alfred , Peter Andreas , Mahlapuu Margit 
Published: July 2023

AbstractHepatocellular carcinoma (HCC) is one of the most fatal and fastest growing malignancies. Recently, nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation, cell injury (hepatocyte ballooning), and different stages of fibrosis, has emerged as a major catalyst for HCC. Because the STE20‐type kinases, MST3 and MST4, have been described as critical molecular regulators of NASH pathophysiology, we here focused on determining the relevance of these proteins in human HCC. By analyzing public datasets and in‐house cohorts, we found that hepatic MST3 and MST4 expression was positively correlated with the incidence and severity of HCC. We also found that the silencing of both MST3 and MST4, but also either of them individually, markedly suppressed the tumorigenesis of human HCC cells including attenuated proliferation, migration, invasion, and epithelial‐mesenchymal transition. Mechanistic investigations revealed lower activation of STAT3 signaling in MST3/MST4‐deficient hepatocytes and identified GOLGA2 and STRIPAK complex as the binding partners of both MST3 and MST4. These findings reveal that MST3 and MST4 play a critical role in promoting the progression of HCC and suggest that targeting these kinases may provide a novel strategy for the treatment of liver cancer.
The role ofSMURFsin non‐cancerous diseases
Authors: Wang Dong , Zou Yuanming , Huang Xinyue , Yin Zeyu , Li Mohan , Xu Jiaqi , Wu Boquan , Li Da , Zhang Ying , Sun Yingxian , Zhang Xingang , Zhang Naijin 
Published: July 2023

AbstractThe ubiquitin‐proteasome system is a crucial mechanism for regulating protein levels in cells, with substrate‐specific E3 ubiquitin ligases serving as an integral component of this system. Among these ligases are SMAD‐specific E3 ubiquitin‐protein ligase 1 (SMURF1) and SMAD‐specific E3 ubiquitin‐protein ligase 2 (SMURF2), which belong to the neural precursor cell‐expressed developmentally downregulated 4 (NEDD4) subfamily of Homologous to E6‐AP COOH terminus (HECT)‐type E3 ligases. As E3 ligases, SMURFs have critical functions in regulating the stability of multiple proteins, thereby maintaining physiological processes such as cell migration, proliferation, and apoptosis. The occurrence of many diseases is attributed to abnormal cell physiology and an imbalance in cell homeostasis. It is noteworthy that SMURFs play pivotal roles in disease progression, with the regulatory functions being complex and either facilitative or inhibitory. In this review, we elucidate the mechanisms by which SMURF1 and SMURF2 can regulate disease progression in non‐cancerous diseases. These significant findings offer potential novel therapeutic targets for various diseases and new avenues for research on SMURF proteins.
Ocular surface inflammation and ectatic corneal disorders
Authors: Erdinest Nir , Wajnsztajn Denise , London Naomi , Solomon Abraham 
Published: July 2023

Purpose of review
Inflammatory mediators are a focus of recent corneal ectasia (CE) research and are a profound, modifiable contributor to CE in general and keratoconus (KC) in particular, opening a path to explore new methods of control. As advanced imaging technology and expanded population screening allow for earlier detection, the possibility of early intervention can profoundly change the prognosis of CE.

Recent findings
Significant increases in the inflammatory mediators and immune components have been observed in the cornea, tear fluid, and blood of ectasia patients, while inflammation dampeners such as vitamin D and their receptors are reduced. Atopy and allergy have a strong association with KC, known to increase itch factors and stimulate eye rubbing, a risk factor in ectasia pathogenesis. Management of atopy or allergic conditions and topical anti-inflammatories has helped stabilize CE disease.

Summary
Strategies such as monitoring inflammatory factors and using immune or inflammatory modulators, including managing subclinical inflammation, may be clinically beneficial in stabilizing the disease and improving outcomes. The detected factors are biomarkers, but as yet unproven to be sensitive or specific enough to be considered biomarkers for early detection of CE. The establishment of such biomarkers could improve the therapeutic outcome.
Real-world pharmacogenetics of statin intolerance: effects of SLCO1B1, ABCG2, and CYP2C9 variants
Authors: Lönnberg K. Ivar , Tornio Aleksi , Hirvensalo Päivi , Keskitalo Jenni , Mustaniemi Anna-Liina , Kiiski Johanna I. , Filppula Anne M. , Niemi Mikko 
Published: July 2023

Objective
The association of SLCO1B1 c.521T>C with simvastatin-induced muscle toxicity is well characterized. However, different statins are subject to metabolism and transport also by other proteins exhibiting clinically meaningful genetic variation. Our aim was to investigate associations of SLCO1B1 c.521T>C with intolerance to atorvastatin, fluvastatin, pravastatin, rosuvastatin, or simvastatin, those of ABCG2 c.421C>A with intolerance to atorvastatin, fluvastatin, or rosuvastatin, and that of CYP2C9*2 and *3 alleles with intolerance to fluvastatin.

Methods
We studied the associations of these variants with statin intolerance in 2042 patients initiating statin therapy by combining genetic data from samples from the Helsinki Biobank to clinical chemistry and statin purchase data.

Results
We confirmed the association of SLCO1B1 c.521C/C genotype with simvastatin intolerance both by using phenotype of switching initial statin to another as a marker of statin intolerance [hazard ratio (HR) 1.88, 95% confidence interval (CI) 1.08–3.25, P = 0.025] and statin switching along with creatine kinase measurement (HR 5.44, 95% CI 1.49–19.9, P = 0.011). No significant association was observed with atorvastatin and rosuvastatin. The sample sizes for fluvastatin and pravastatin were relatively small, but SLCO1B1 c.521T>C carriers had an increased risk of pravastatin intolerance defined by statin switching when compared to homozygous reference T/T genotype (HR 2.11, 95% CI 1.01–4.39, P = 0.047).

Conclusion
The current results can inform pharmacogenetic statin prescribing guidelines and show feasibility for the methodology to be used in larger future studies.
Nurse support for pain and anxiety control in women undergoing diagnostic hysteroscopy: a randomized clinical trial
Authors: de Campos Belisa Franco , Benetti-Pinto Cristina Laguna , Yela Daniela Angerame 
Published: July 2023

Abstract

Objective
The aim of the study is to evaluate the effectiveness of nurse support for controlling pain and anxiety in women undergoing diagnostic hysteroscopy.

Methods
This randomized clinical trial included 192 women who underwent diagnostic hysteroscopy at an academic hospital. Women were divided into two groups: those who received nurse support (n = 95) as the intervention group and those who did not (n = 97) as the control group.

Results
The mean age of women was 54.24 ± 13.91 years and 53.47 ± 13.24 years (P = 0.670) in the intervention and control groups, respectively. There were no differences in clinical and sociodemographic variables between the groups. The mean pain score during examination was 6.62 ± 2.60 and 7.05 ± 2.30 (P = 0.327) for the intervention and control groups, respectively. Most women in both groups were satisfied with the examination (P = 0.777). There was a significant reduction in systolic blood pressure and heart rate during the examination in the intervention group (P = 0.029 and P < 0.001, respectively) and an increase in anxiety scores in the control group (P = 0.009).

Conclusions
There was no reduction in pain scores during hysteroscopy with nurse support. However, the control group showed an increase in anxiety scores after the hysteroscopy.
PNEUMATIC DISPLACEMENT OF HEMORRHAGIC BACILLARY LAYER DETACHMENT
Authors: Alderman David R. B. , Bracha Peter 
Published: July 2023

Purpose:
The purpose of this study was to describe the management of a hemorrhagic bacillary layer detachment (BALAD) in a patient with neovascular age-related macular degeneration.

Methods:
The clinical records and imaging were reviewed.

Results:
A 74-year-old woman presented with acute-onset hemorrhagic neovascular age-related macular degeneration with a large hemorrhagic BALAD. The intra-BALAD hemorrhage was amenable to displacement with SF6 pneumatic displacement with subsequent VA recovery.

Conclusion:
Sulfur hexafluoride (SF6) pneumatic displacement in combination with aflibercept injection is a viable means by which to manage a hemorrhagic BALAD in the context of neovascular age-related macular degeneration. Displacement of large intra-BALAD hemorrhages can result in good visual recovery.
Impact of Hurricane Harvey on Inpatient Asthma Hospitalization Visits Within Southeast Texas, 2016–2019
Authors: Li Yiyao , Buendia Justin , Sears Sabeena , Ibrahimovic Mirela , Bertero Heather , Wiseman Rachel , Bhakta Nimisha 
Published: July 2023

Objective
The aim of the study is to estimate inpatient asthma hospital visit rates among impacted Texans in Public Health Region 6/5S during the year of and after Hurricane Harvey.

Methods
Asthma inpatient hospitalization discharges were collected from the Texas Health Care Information Collection database (2016–2019).

Results
Females (age-adjusted rates [AARs] = 4.8–5.0) and Black Texans (AARs = 5.0–8.1) experienced significantly higher AARs compared with males and White Texans during the year of and after Harvey. During the year of Hurricane Harvey, females were 1.49 times as likely to have an inpatient asthma visit compared with males, while Black Texans were 2.78 times as likely to have an inpatient asthma hospitalization compared with White Texans.

Conclusions
Findings from this study may assist public health professionals and local officials to allocate future resources to the most impacted subgroups as well as establish effective processes to mitigate consequences.
Nutritional and feeding challenges in aerodigestive patients
Authors: Chen Charles B. 
Published: July 2023

Purpose of review
Aerodigestive disorders encompass conditions that affect both the airway and gastrointestinal tract. These include conditions such as acquired and congenital defects of the airway and esophagus as well as neuromuscular disorders. Patients often suffer from dysphagia, aspiration, and respiratory disorders. This article will provide a review of current practices in the management of feeding disorders, oropharyngeal dysphagia, and nutritional support in the aerodigestive population.

Recent findings
Oral aversion, aspiration, and feeding-tube dependence are all commonly encountered problems in the aerodigestive population. Intensive inpatient and outpatient programs along with use of appetite stimulants and psychotropic medications may help to improve feeding-related disorders. Aspiration affects many patients and requires close monitoring of clinical symptoms along with routine assessment with video fluoroscopy. Developments in blenderized feeds and formula supplementation have also provided new options for patients with feeding intolerance.

Summary
Patients with aerodigestive disorders require complex medical care, and multidisciplinary teams are the most effective in addressing their medical needs. Advances in feeding, occupational, and pharmacologic therapy have allowed healthcare providers to better address the needs of these patients.
Screening for mental health problems in childhood cancer survivorship: a systematic review
Authors: Holmer Pauline , Bolliger Céline , Vokinger Anna Katharina , Dyntar Daniela , Michel Gisela 
Published: July 2023

Abstract
Many survivors of childhood cancer suffer from psychological late effects. Therefore, regular psychological screening is strongly advised. Experts recommend screening for mental disorders and symptoms for all survivors at every follow-up visit, regardless of age. However, there is little practical guidance on screening for mental health problems in childhood cancer survivorship care. The aims of this systematic review were to (a) collect comprehensive information on available screening tools, (b) determine which health care professionals performed the screening, and (c) identify practical considerations regarding the timing of screening. The databases PubMed, PsycINFO, and CINAHL were systematically searched for peer-reviewed publications concerning childhood cancer, mental health problems, survivorship, and screening published between January 1990 and January 2023. The search yielded 2268 potentially relevant articles, of which 32 were included in the narrative synthesis. We found that (a) many suitable screening tools are available for the target population, of which the Distress Thermometer, Brief Symptom Inventory-18, Symptom Checklist-90, and Pediatric Quality of Life Inventory were the most commonly used in all studies; (b) professionals of different disciplines were involved in screening, and examples include clinical nurse specialists and psychologists; and (c) early onset, regular, and long-term screening are recommended if resources are available. In conclusion, selecting a screening tool in a clinical setting depends on various factors such as time and cost. However, many brief screening tools can be easily implemented without a large investment of resources. Furthermore, professionals from various disciplines can perform the screening. If they have no background in psychology, training is recommended to give them confidence in dealing with mental health issues. In conclusion, consistent and regular mental health screening is crucial for childhood cancer survivors, and we believe that the benefits outweigh the costs.
Reconstruction of Finger Soft Tissue Defects With a Thinned Free Anterolateral Thigh Flap
Authors: Sơn Trần Thiết , Việt Dung Phạm Thị , Nghĩa Phan Tuấn , Hồng Thúy Tạ Thị 
Published: July 2023

Background
Reconstructing complex soft tissue defects of the finger requires both functional and aesthetic aspects. There are many free tissue transfers as suitable options for digital resurfacing. The anterolateral thigh (ALT) flap is not the first choice for reconstruction of this area because it has the disadvantage that the subcutaneous tissue is too thick; however, its use as a thinned form has yet to be described much. This study presents the flap thinning technique in the small-sized ALT flap for the finger soft tissue defect.

Method
From May 2009 to March 2018, 10 patients with complete circumferential or semicircumcision defects in the fingers underwent reconstructive procedures that included thinned ALT flap transfer. Finger soft tissue damage due to contusion trauma includes loss of skin and exposure of the bone and tendon. The flap is thinned in 2 different ways: peripheral thinning and total microsurgical thinning, which is selected based on the perforator vessel structure of the flap.

Result
The ALT flap sizes, averaging 4–9 cm wide and 6–12 cm long, were thinned to 4–7 mm. One perforator was included in the flaps with a pedicle length average of 6.1 cm. The flaps survived entirely in all patients except one with a 30% area in the distal part of the thinned ALT flap that became necrotic because of venous occlusion. Donor sites were closed primarily for all patients. No patients required secondary flap defatting.

Conclusions
The small thinned ALT perforator flap can be an excellent option for full circumferential or semicircumferential soft tissue defects of the finger. Follow-up showed this as an excellent alternative for finger reconstruction in terms of aesthetic appearance and functional outcome.
The Innovation Press
Authors: Kirloskar Kunal M. , Haffner Zoë K. , Abadeer Andrew , Yosaitis John , Baker Stephen B. ,   MI2 Innovations
Published: July 2023

Abstract
Three-dimensional (3D) printing continues to revolutionize the field of plastic surgery, allowing surgeons to adapt to the needs of individual patients and innovate, plan, or refine operative techniques. The utility of this manufacturing modality spans from surgical planning, medical education, and effective patient communication to tissue engineering and device prototyping and has valuable implications in every facet of plastic surgery. Three-dimensional printing is more accessible than ever to the surgical community, regardless of previous background in engineering or biotechnology. As such, the onus falls on the surgeon-innovator to have a functional understanding of the fundamental pipeline and processes in actualizing such innovation. We review the broad range of reported uses for 3D printing in plastic surgery, the process from conceptualization to production, and the considerations a physician must make when using 3D printing for clinical applications. We additionally discuss the role of computer-assisted design and manufacturing and virtual and augmented reality, as well as the ability to digitally modify devices using this software. Finally, a discussion of 3D printing logistics, printer types, and materials is included. With innovation and problem solving comprising key tenets of plastic surgery, 3D printing can be a vital tool in the surgeon's intellectual and digital arsenal to span the gap between concept and reality.
Impact of Dynamic Tongue Reconstruction on Sequential Changes of Swallowing Function in Patients Undergoing Total or Near-Total Glossectomy
Authors: Kim Young Chul , Woo Soo Hyun , Jeong Woo Shik , Oh Tae Suk , Choi Jong Woo 
Published: July 2023

Purpose
This study aimed to compare the effects of motor-innervated free flap on sequential changes of swallowing function in patients undergoing total or near-total glossectomy with laryngeal preservation.

Materials and Methods
The medical charts of 21 patients who underwent tongue reconstruction after total or near-total glossectomy between April 2015 and December 2020 were retrospectively reviewed. Patients were divided into groups by reconstruction type: conventional, reconstruction using an anterolateral thigh free flap (n = 11), and dynamic, reconstruction using an anterolateral thigh with innervated vastus lateralis flap (n = 10). Demographics, surgical details, and survival outcomes were investigated. A videofluoroscopic penetration-aspiration scale and functional outcome swallowing scale were analyzed according to postoperative time courses, classified as within 6 months, 6 to 12 months, and after 12 months postoperative. A time-to-event analysis was performed for gastrostomy tube status.

Results
The dynamic group showed improved swallowing outcomes at 6 to 12 months postoperative (dynamic vs conventional group, penetration-aspiration scale: 3 ± 1.51 vs 6 ± 1.63, P = 0.024; functional outcome swallowing scale: 1.89 ± 1.36 vs 4 ± 1.41, P = 0.009). In the multivariate analysis, the dynamic group showed a decreased probability of decompensated swallowing function at 6 to 12 months postoperative (odds ratio, 0.062; 95% confidence interval, 0.004–1.084; P = 0.057). A time-to-event analysis revealed no significant difference in gastrostomy tube status between the dynamic and the conventional group.

Conclusions
Considering higher mortality in patients subjected to total or near-total glossectomy, dynamic reconstruction with motor-innervated free flap is worth to perform in terms of enhancing the swallowing function within 1-year postoperative period, thereby improving the quality of life.
Wide Awake Trigger Finger Releases Performed in the United States
Authors: Mookerjee Vikram G. , Kammien Alexander J. , Prsic Adnan , Grauer Jonathan N. , Colen David L. 
Published: July 2023

BackgroundTrigger finger release (TFR) has traditionally been performed in outpatient operating rooms. More recently, TFR may be performed in the office setting to achieve greater efficiency and cost savings.MethodsThe 2010–2020 Q2 PearlDiver M91Ortho data set was analyzed for cases of TFR. Exclusion criteria were age less than 18 years, <30 days of postoperative records, concomitant hand surgery, monitored anesthesia use, and inpatient surgery. Age, sex, and Elixhauser comorbidity index were recorded. Operating room and office procedures were matched 4:1 based on patient characteristics. Total and physician reimbursement for the day of surgery, as well as 30-day narcotics prescriptions, emergency department (ED) visits, and surgical site infections (SSI) were determined.ResultsBefore matching, TFRs were found to be increasingly performed in the office (from 7.9% in 2010 to 14.6% in 2020). Matched cohorts consisted of 63,951 operating room and 15,992 office procedures. Office procedures had lower mean total reimbursements ($435 vs $752,P< 0.001), slightly lower mean physician reimbursements ($420 vs $460,P< 0.001), and lower rates of narcotic prescriptions (30.5% vs 50.5%,P< 0.001) and 30-day ED visits (2.2% vs 2.9%,P< 0.05). There was no difference in 30-day SSI (0.5% vs 0.6%,P= 0.374).ConclusionsIn-office TFR is becoming increasingly prevalent. After matching, in-office TFRs were associated with lesser costs to the system, lower narcotic prescriptions, and fewer postoperative ED visits, without increased SSI. Although it is important to perform procedures in the best location for the patient, physician, and system, the current study supports the increased value offered by in-office TFR.