bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infrastructure and the cognitive ecosystem: an irrevocable transformation
Authors: Chester Mikhail V , Allenby Braden 
Published: August 2023

Abstract
Disruption of legacy infrastructure systems by novel digital and connected technologies represents not simply the rise of cyberphysical systems as hybrid physical and digital assets but, ultimately, the integration of legacy systems into a new cognitive ecosystem. This cognitive ecosystem, an ecology of massive data flows, artificial intelligence, institutional and intellectual structures, and connected technologies, is poised to alter how humans and artificial intelligence understand and control our world. Infrastructure managers need to be ready for this paradigm shift, recognizing their systems are increasingly being absorbed into an emerging suite of data, analytical tools, and decisionmaking technologies that will fundamentally restructure how legacy systems behave and are controlled, how decisions are made, and most importantly how workers interact with the systems. Infrastructure managers must restructure their organizations and engage in cross-organizational sensemaking if they are to be capable of navigating the complexity of the cognitive ecosystem. The cognitive ecosystem is fundamentally poised to change what infrastructures are, necessitating the need for managers to take a close look at the functions and actions of their own systems. The continuing evolution of the Anthropocene and the cognitive ecosystem has profound implications for infrastructure education. A sustained commitment to change is necessary that restructures and reorients infrastructure organizations within the cognitive ecosystem, where knowledge is generated, and control of services is wielded by myriad stakeholders.
Jeffrey imaging revisited
Authors: Fusco Melissa 
Published: August 2023

Abstract
In ‘The logic of partial supposition’ (Analysis vol. 81), Benjamin Eva and Stephan Hartmann investigate partial imaging, a credence-revision method which combines the partiality familiar from Jeffrey Conditioning(The Logic of Decision, 1983) with the formal notion of imaging familiar from Lewis’s ‘Causal decision theory’ (1981). They argue that because partial imaging is non-monotonic, it ‘fail[s] to provide a plausible account of the norms of partial subjunctive suppositions’.
In this note, I present a notion of partial imaging that does satisfy monotonicity, and discuss some of the applications and ramifications. The account frames conditioning as a form of imaging, and rejects Gärdenfors’s principle of linearity in ‘Imaging and conditionalization’ (1982).
Induced endometrial inflammation compromises conceptus development in dairy cattle
Authors: Husnain Ali , Arshad Usman , Zimpel Roney , Schmitt Eduardo , Dickson Mackenzie J , Perdomo Milerky C , Marinho Mariana N , Ashrafi Nadia , Graham Stewart F , Bishop Jeanette V , Hansen Thomas R , Jeong Kwang C , Gonella-Diaza Angela M , Chebel Ricardo C , Sheldon I Martin , Bromfield John J , Santos José E P 
Published: August 2023

AbstractEndometrial inflammation is associated with reduced pregnancy per artificial insemination (AI) and increased pregnancy loss in cows. It was hypothesized that induced endometritis alters histotroph composition and induces inflammatory signatures on conceptus that compromise development. In Experiment 1, lactating cows were assigned to control (CON; n = 23) or to an intrauterine infusion of Escherichia coli and Trueperella pyogenes (ENDO; n = 34) to induce endometritis. Cows received AI 26 days after treatment, and the uterine fluid and conceptuses were collected on day 16 after AI. In Experiment 2, Holstein heifers were assigned to CON (n = 14) or ENDO (n = 14). An embryo was transferred on day 7 of the estrous cycle, and uterine fluid and conceptuses were recovered on day 16. Composition of histotroph and trophoblast and embryonic disc gene expression were assessed. Bacterial-induced endometritis in lactating cows altered histotroph composition and pathways linked to phospholipid synthesis, cellular energy production, and the Warburg effect. Also, ENDO reduced conceptus length in cows and altered expression of genes involved in pathogen recognition, nutrient uptake, cell growth, choline metabolism, and conceptus signaling needed for maternal recognition of pregnancy. The impact of ENDO was lesser on conceptuses from heifers receiving embryo transfer; however, the affected genes and associated pathways involved restricted growth and increased immune response similar to the observed responses to ENDO in conceptuses from lactating cows. Bacterial-induced endometrial inflammation altered histotroph composition, reduced conceptus growth, and caused embryonic cells to activate survival rather than anabolic pathways that could compromise development.
Evaluating Fiscal Policy Under Cyclical Balance in Developed Countries
Authors: Lu Ching-Yi , Chang Ming-Jen 
Published: August 2023

Abstract
This study investigates the cyclical patterns of fiscal policy rules using various policy variables that respond to the macroeconomic performance of developed countries over the past few decades. The study reveals that regardless of whether the economy is in a recession or a boom, fiscal policy basically displays counter-cyclical behavior. However, the degree of cyclicality varies depending on the output gap measurements chosen and the countries analyzed. Additionally, the estimates using various fiscal policy indicators demonstrate a strong time variation in fiscal cyclical behavior, resulting in a significant increase in the counter-cyclicality of the fiscal balance. The article also applies the time-varying coefficients vector autoregression model to assess the effects of fiscal policy on output and finds that a boost in the cyclically adjusted primary balance positively impacts production in the short run.
Experimental Design Application for Measuring Histamine in Tuna Fish Samples by Phenyl Isothiocyanate Derivation Method Using Ultra-Performance Liquid Chromatography
Authors: Ameri Maede , Daryanavard Seyed Mosayeb 
Published: August 2023

Abstract
Histamine as an important biogenic amino acid was measured in tuna fish samples by ultra-performance liquid chromatography using a phenyl isothiocyanate derivative. Minitab software was used to design the experiment and investigate the effective factors during the process, which includes screening and optimization steps. A partial factorial design was used in the screening stage and a central composite design was used in the optimization. Effective parameters in histamine derivatized were examined in the screening step including triethylamine volume, phenyl isothiocyanate volume, reaction temperature, reaction time and mobile phase pH. Then, in the optimization, effective parameters were identified and finally, the calibration curve was drawn from a concentration of 0.5–10.0 μg.mL−1 for histamine derivatized and a correlation coefficient of 0.994 was obtained for histamine derivatized. The method detection limit was 0.36 μg.mL−1 and the limit of quantification (LOQ) was 1.19 μg.mL−1. The relative standard deviation of the method was obtained for concentrations of 1.0–100.0 μg.mL−1 in the range between 1.06 and 2.21%. The recovery method was obtained from 90.8 to 103.1% for measuring histamine derivatized in real fish samples.
A Blockchain-Based Public Key Infrastructure For IoT-Based Healthcare Systems
Authors: Joseph Antony Amalan , Singh Kunwar 
Published: August 2023

Abstract
Secure exchange of data among the various stake holders of healthcare systems is of prime importance. As the size of the healthcare networks grew, several variants of Public Key Infrastructures (PKIs) were proposed as a means to achieve reliable authentication, confidentiality, non-repudiation, etc. The most prevalent approach to PKI has been the use of Certificate Authorities (CAs). But, events like the breach of the CA DigiNotar, and the ensuing fake certificates for Google, among other noteworthy high-profile domains, has cast doubts on the reliability of a CA, and therefore on PKIs modelled as CAs too. In this paper, we propose a new approach to a healthcare PKI modelled on a blockchain, incorporating Elliptic Curve Cryptographic methods for secure key generations.
Suppression of hemp russet mite, Aculops cannabicola (Acari: Eriophyidae), in industrial hemp in greenhouse and field
Authors: Szczepaniec Adrianna , Lathrop-Melting Abby , Janecek Taylor , Nachappa Punya , Cranshaw Whitney , Alnajjar Gabriel , Axtell Alice 
Published: August 2023

Abstract
Hemp russet mite, Aculops cannibicola Farkas (Acari: Eriophyidae), is one of the key pests of hemp, Cannabis sativa L. (Rosales: Cannabaceae). Hemp russet mite feeds primarily on new growth and can reach high densities, frequently exceeding a thousand mites per leaf, and leading to a decrease in yield and quality of cannabinoids. The objective of this experiment was to determine the efficacy of reduced-risk pesticides used in organic crop protection as well as conventional insecticides in managing hemp russet mites in a greenhouse and field. Hemp (var. Unicorn) was exposed to leaves heavily infested with hemp russet mites, and once mite densities reached an average of 50 mites per leaf, the following insecticides were applied to the plants: abamectin, etoxazole, fenpyroximate, rosemary oil, and 2 concentrations of a mineral oil. An application of sulfur was also included in the field experiment. Treatments were replicated 9 times in the greenhouse and 6 times in the field. Each of the pesticides significantly reduced hemp russet mite densities in the greenhouse, with all treatments resulting in significant decrease in mite populations 10 days after the initial treatment that persisted until the end of the experiment. On the other hand, only fenpyroximate, sulfur, and rosemary oil provided strong and effective suppression of the mites in the field. This is the first study to test these products against hemp russet mites in hemp, and our outcomes indicate that several pesticides available for organic crop production can provide effective control of the pest.
Predators attracted to combination of bark beetle pheromones and host kairomones in pine forests of southeastern United States
Authors: Miller Daniel R , Asaro Christopher 
Published: August 2023

Abstract
In 2006, we evaluated the effects of combining lures releasing pine host kairomones (ethanol + α-pinene) with lures releasing bark beetle pheromones (ipsenol + ipsdienol) on trap catches of predators associated with bark and woodboring beetles in Florida, Georgia, Louisiana, and Virginia. Catches in traps baited with all 4 compounds were greater than those in traps baited with either binary blend for the common predators Thanasimus dubius (F.) (Coleoptera: Cleridae), Temnoscheila virescens (F.) (Coleoptera: Trogossitidae), Aulonium tuberculatum LeConte (Coleoptera: Zopheridae), and Lasconotus spp. (Coleoptera: Zopheridae). The same was true for: Enoclerus nigripes (Say) (Coleoptera: Cleridae) at 2 of 3 locations; Platysoma cylindricum (Paykull) (Coleoptera: Histeridae) at 3 of 4 locations; and Corticeus spp. (Coleoptera: Tenebrionidae) at 2 of 6 locations. In contrast, the addition of ethanol + α-pinene to traps baited with ipsenol + ipsdienol reduced catches of Platysoma attenuatum LeConte (Coleoptera: Histeridae) at 2 of 4 locations.
A valve embolized twice: a case report of Sapien 3 embolization in left ventricle and left atrium during transcatheter transapical mitral valve-in-valve implantations for a failed bioprosthesis
Authors: Lin Huan-Chiu , Lee Yung-Tsai , Tsao Tien-Ping , Yin Wei-Hsian 
Published: August 2023

Abstract

Background
Transcatheter mitral valve-in-valve (TMVIV) using the Sapien 3 (Edwards Lifesciences, Irvine, CA, USA) transcatheter heart valve is associated with high technical success and sustained valve performance. However, complications may occur or be detected during or after the procedure.

Case summary
We herein describe a rare case of a 59-year-old female who underwent TMVIV for a failed surgical mitral bioprosthesis. During the procedure, the device was embolized twice into the left ventricle and left atrium, respectively, resulting from the crimped transcatheter valve partially detaching from the balloon of the Certitude delivery system during passage through a tight transapical sheath. Fortunately, we were able to catch the dislodged valve and anchor it by the partially inflated device balloon, followed by successful repositioning and deployment.

Discussion
In cases where the valve has already detached, as in the present case, the sheath may be advanced against the proximal end of the valve as a pusher, providing good support to push the entire system to cross the bioprosthesis. Then, the delivery catheter should be withdrawn with the counteraction of the sheath in order to correct the interrelated positions of the valve and the balloon. Finally, the valve can be positioned and deployed after the sheath is withdrawn.
Expert systematic review on the choice of conduits for coronary artery bypass grafting: endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and The Society of Thoracic Surgeons (STS)
Authors: Gaudino Mario , Bakaeen Faisal G , Sandner Sigrid , Aldea Gabriel S , Arai Hirokuni , Chikwe Joanna , Firestone Scott , Fremes Stephen E , Gomes Walter J , Bong-Kim Ki , Kisson Kalie , Kurlansky Paul , Lawton Jennifer , Navia Daniel , Puskas John D , Ruel Marc , Sabik Joseph F , Schwann Thomas A , Taggart David P , Tatoulis James , Wyler von Ballmoos Moritz 
Published: August 2023

Abstract

Preamble
The finalized document was endorsed by the EACTS Council and STS Executive Committee before being simultaneously published in the European Journal of Cardio-thoracic Surgery (EJCTS) and The Annals of Thoracic Surgery (The Annals) and the Journal of Thoracic and Cardiovascular Surgery (JTCVS).
The socioeconomic burden of acromegaly
Authors: Störmann Sylvère , Cuny Thomas 
Published: August 2023

Abstract
Acromegaly is a rare and insidious disease characterized by chronic excess growth hormone, leading to various morphological changes and systemic complications. Despite its low prevalence, acromegaly poses a significant socioeconomic burden on patients and healthcare systems. This review synthesizes the current state of knowledge on the psychosocial burden, disability, impact on daily life, and cost of acromegaly disease, focusing on the quality of life, partnership, medical care and treatment afflictions, participation in daily activities, professional and leisure impairment, and cost of treatment for acromegaly and its comorbidities. It also examines management strategies, coping mechanisms, and interventions aimed at alleviating this burden. A comprehensive understanding of the extent of the socioeconomic burden in acromegaly is crucial to develop effective strategies to improve treatment and care. Further research is warranted to explore the myriad factors contributing to this burden, as well as the efficacy of interventions to alleviate it, ultimately enhancing the quality of life for patients with acromegaly.
Expansion of the immature B lymphocyte compartment in Graves' disease
Authors: Lane Laura Claire , Cheetham Timothy David , Razvi Salman , Allinson Kathleen , Pearce Simon Henry Schofield 
Published: August 2023

AbstractObjectiveThe specific mechanisms driving autoimmunity in Graves' disease (GD) remain largely unknown. Kappa-deleting recombination excision circles (KRECs) are circular DNA molecules generated during B cell maturation in the bone marrow which provide a measure of B cell production and proliferation. We aimed to investigate the association between KRECs and B cell subpopulations, with thyroid status and clinical outcome in GD patients.MethodsKappa-deleting recombination excision circles were measured by quantitative real-time PCR using a triple-insert plasmid control in 132 GD patients and 140 healthy controls. In addition, KRECs in GD patients on withdrawal of antithyroid drug (ATD) and 6-10 weeks later were analysed according to a clinical outcome at 1 year. Flow cytometry was performed on isolated CD19+ B cells to quantitate 7 B lymphocyte subpopulations in 65 GD patients.ResultsCirculating KRECs were higher in GD vs. controls (P = 1.5 × 10−9) and demonstrated a positive correlation to thyroid hormones and autoantibodies (free thyroxine: P = 2.14 × 10−5, rho = .30; free triiodothyronine: P = 1.99 × 10−7, rho = .37; thyroid stimulating hormone receptor autoantibodies: P = 1.36 × 10−5, rho = .23). Higher KRECs in GD patients 6-10 weeks after ATD withdrawal were associated with relapse of hyperthyroidism at 1 year (P = .04). The KRECs were positively correlated to the total CD19+ B cell count (P = 3.2 × 10−7).ConclusionsThis study reports a robust association between KRECs and GD, highlighting the importance of B cells in the pathogenesis of GD and the influence of thyroid status on B cell activity. The findings indicate a potential role for KRECs as a marker of disease activity and outcome in GD.
Unipolar-voltage-based evaluation of left atrial tissue properties and ablation outcome in patients with atrial fibrillation
Authors: Kamioka Masashi , Makimoto Hisaki , Watanabe Tomonori , Watanabe Hiroaki , Okuyama Takafumi , Kaneshiro Takashi , Hijioka Naoko , Yokota Ayako , Komori Takahiro , Kabutoya Tomoyuki , Imai Yasushi , Kario Kazuomi 
Published: August 2023

Abstract

Aims
The relationship between local unipolar voltage (UV) in the pulmonary vein (PV)-ostia and left atrial wall thickness (LAWT) and the utility of these parameters as indices of outcome after atrial fibrillation (AF) ablation remain unclear.

Methods and results
Two-hundred seventy-two AF patients who underwent AF ablation were enrolled. Unipolar voltage of PV-ostia was measured using a CARTO system, and LAWT was measured using computed tomography. The primary endpoint was atrial tachyarrhythmia (ATA) recurrence including AF. The ATA recurrence was documented in 74 patients (ATA-Rec group). The UV and LAWT of the bilateral superior PV roof to posterior and around the right-inferior PV in the ATA-Rec group were significantly greater than in patients without ATA recurrence (ATA-Free group) (P &lt; 0.001). The UV had a strong positive correlation with LAWT (R2 = 0.446, P &lt; 0.001). The UV 2.7 mV and the corresponding LAWT 1.6 mm were determined as the cut-off values for ATA recurrence (P &lt; 0.001, respectively). Multisite LA high UV (HUV, ≥4 areas of &gt;2.7 mV) or multisite LA wall thickening (≥5 areas of &gt;1.6 mm), defined as LA hypertrophy (LAH), was related to higher ATA recurrence. Among 92 LAH patients, 66 had HUV (LAH-HUV) and the remaining 26 had low UV (LAH-LUV), characterized by history of non-paroxysmal AF and heart failure, reduced LV ejection fraction, or enlarged LA. In addition, LAH-LUV showed the worst ablation outcome, followed by LAH-HUV and No LAH (log-rank P &lt; 0.001).

Conclusion
Combining UV and LAWT enables us to stratify recurrence risk and suggest a tailored ablation strategy according to LA tissue properties.
miR-871-5p/PGC1α Regulates Aging-Induced Lipid Deposition in Hepatocytes Through Fatty Acid β-Oxidation
Authors: Zheng Ying , Chen Xiaoling , Lu Ting , Lin Zhiyong , Liu Chaoqi , Yuan Ding , Yuan Chengfu 
Published: August 2023

Abstract
This study investigated the role of the miR-871-5p/proliferator-activated receptor α (PGC1α) pathway in ameliorating hepatic steatosis. We examined miR-871-5p expression in liver tissues of aging mice and AML12 senescent cells co-induced by low serum and palmitic acid (PA). Bioinformatics and multiple experiments were employed to validate the expression level of the target gene PGC1α for miR-871-5p. In this study, we aimed to investigate the potential role of miR-871-5p in regulating hepatic lipid deposition associated with aging. To do so, we performed in vitro transfection of both miR-871-5p mimic and inhibitor into senescent hepatocytes. Our results showed that miR-871-5p could inhibit PGC1α expression and cause lipid deposition in the liver due to aging. miR-871-5p controls this process by regulating PGC1α/fatty acid β-oxidation. H&E staining displayed the appearance of fat vacuoles in the livers of aging mice, and fatty acid β-oxidation-related genes (acyl-coenzyme A oxidase 1 carnitine palmitoyl transferase 1α and peroxisome proliferator-activated receptor α) expression was significantly reduced. Lipogenic genes (sterol regulatory element binding protein 1C and fatty acid synthase) expression level was increased in the livers of aging mice. In AML12 cells co-induced by low serum and PA, miR-871-5p mimics decreased PGC1α expression and increased lipid droplet accumulation in senescent hepatocytes. Conversely, miR-871-5p inhibitor promoted PGC1α expression and reduced lipid deposition in senescent hepatocytes. Our findings suggest that inhibiting miR-871-5p could be crucial in ameliorating aging-associated hepatic steatosis. These findings offer valuable insights into the molecular mechanisms driving hepatic steatosis in aging.
Comparison between alarm-based and probability-based earthquake forecasting methods
Authors: Biondini Emanuele , Gasperini Paolo 
Published: August 2023

SUMMARY
In a recent work, we applied the every earthquake a precursor according to scale (EEPAS) probabilistic model to the pseudo-prospective forecasting of shallow earthquakes with magnitude $M\ 5.0$ in the Italian region. We compared the forecasting performance of EEPAS with that of the epidemic type aftershock sequences (ETAS) forecasting model, using the most recent consistency tests developed within the collaboratory for the study of earthquake predictability (CSEP). The application of such models for the forecasting of Italian target earthquakes seems to show peculiar characteristics for each of them. In particular, the ETAS model showed higher performance for short-term forecasting, in contrast, the EEPAS model showed higher forecasting performance for the medium/long-term. In this work, we compare the performance of EEPAS and ETAS models with that obtained by a deterministic model based on the occurrence of strong foreshocks (FORE model) using an alarm-based approach. We apply the two rate-based models (ETAS and EEPAS) estimating the best probability threshold above which we issue an alarm. The model parameters and probability thresholds for issuing the alarms are calibrated on a learning data set from 1990 to 2011 during which 27 target earthquakes have occurred within the analysis region. The pseudo-prospective forecasting performance is assessed on a validation data set from 2012 to 2021, which also comprises 27 target earthquakes. Tests to assess the forecasting capability demonstrate that, even if all models outperform a purely random method, which trivially forecast earthquake proportionally to the space–time occupied by alarms, the EEPAS model exhibits lower forecasting performance than ETAS and FORE models. In addition, the relative performance comparison of the three models demonstrates that the forecasting capability of the FORE model appears slightly better than ETAS, but the difference is not statistically significant as it remains within the uncertainty level. However, truly prospective tests are necessary to validate such results, ideally using new testing procedures allowing the analysis of alarm-based models, not yet available within the CSEP.