bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression
Authors: Macke Amanda J. , Pachikov Artem N. , Divita Taylor E. , Morris Mary E. , LaGrange Chad A. , Holzapfel Melissa S. , Kubyshkin Anatoly V. , Zyablitskaya Evgeniya Y. , Makalish Tatiana P. , Eremenko Sergey N. , Qiu Haowen , Riethoven Jean-Jack M. , Hemstreet George P. , Petrosyan Armen 
Published: June 2023

Abstract

Prostate cancer progression to the lethal metastatic castration-resistant phenotype (mCRPC) is driven by αv integrins and is associated with Golgi disorganization and activation of the ATF6 branch of unfolded protein response (UPR). Overexpression of integrins requires N-acetylglucosaminyltransferase-V (MGAT5)-mediated glycosylation and subsequent cluster formation with Galectin-3 (Gal-3). However, the mechanism underlying this altered glycosylation is missing. For the first time, using HALO analysis of IHC, we found a strong association of integrin αv and Gal-3 at the plasma membrane (PM) in primary prostate cancer and mCRPC samples. We discovered that MGAT5 activation is caused by Golgi fragmentation and mislocalization of its competitor, N-acetylglucosaminyltransferase-III, MGAT3, from Golgi to the endoplasmic reticulum (ER). This was validated in an ethanol-induced model of ER stress, where alcohol treatment in androgen-refractory PC-3 and DU145 cells or alcohol consumption in patient with prostate cancer samples aggravates Golgi scattering, activates MGAT5, and enhances integrin expression at PM. This explains known link between alcohol consumption and prostate cancer mortality. ATF6 depletion significantly blocks UPR and reduces the number of Golgi fragments in both PC-3 and DU145 cells. Inhibition of autophagy by hydroxychloroquine (HCQ) restores compact Golgi, rescues MGAT3 intra-Golgi localization, blocks glycan modification via MGAT5, and abrogates delivery of Gal-3 to the cell surface. Importantly, the loss of Gal-3 leads to reduced integrins at PM and their accelerated internalization. ATF6 depletion and HCQ treatment synergistically decrease integrin αv and Gal-3 expression and temper orthotopic tumor growth and metastasis.

Implications:
Combined ablation of ATF6 and autophagy can serve as new mCRPC therapeutic.
Deep Learning Versus Neurologists: Functional Outcome Prediction in LVO Stroke Patients Undergoing Mechanical Thrombectomy
Authors: Herzog Lisa , Kook Lucas , Hamann Janne , Globas Christoph , Heldner Mirjam R. , Seiffge David , Antonenko Kateryna , Dobrocky Tomas , Panos Leonidas , Kaesmacher Johannes , Fischer Urs , Gralla Jan , Arnold Marcel , Wiest Roland , Luft Andreas R. , Sick Beate , Wegener Susanne 
Published: June 2023

BACKGROUND:
Despite evolving treatments, functional recovery in patients with large vessel occlusion stroke remains variable and outcome prediction challenging. Can we improve estimation of functional outcome with interpretable deep learning models using clinical and magnetic resonance imaging data?

METHODS:
In this observational study, we collected data of 222 patients with middle cerebral artery M1 segment occlusion who received mechanical thrombectomy. In a 5-fold cross validation, we evaluated interpretable deep learning models for predicting functional outcome in terms of modified Rankin scale at 3 months using clinical variables, diffusion weighted imaging and perfusion weighted imaging, and a combination thereof. Based on 50 test patients, we compared model performances to those of 5 experienced stroke neurologists. Prediction performance for ordinal (modified Rankin scale score, 0–6) and binary (modified Rankin scale score, 0–2 versus 3–6) functional outcome was assessed using discrimination and calibration measures like area under the receiver operating characteristic curve and accuracy (percentage of correctly classified patients).

RESULTS:
In the cross validation, the model based on clinical variables and diffusion weighted imaging achieved the highest binary prediction performance (area under the receiver operating characteristic curve, 0.766 [0.727–0.803]). Performance of models using clinical variables or diffusion weighted imaging only was lower. Adding perfusion weighted imaging did not improve outcome prediction. On the test set of 50 patients, binary prediction performance between model (accuracy, 60% [55.4%–64.4%]) and neurologists (accuracy, 60% [55.8%–64.21%]) was similar when using clinical data. However, models significantly outperformed neurologists when imaging data were provided, alone or in combination with clinical variables (accuracy, 72% [67.8%–76%] versus 64% [59.8%–68.4%] with clinical and imaging data). Prediction performance of neurologists with comparable experience varied strongly.

CONCLUSIONS:
We hypothesize that early prediction of functional outcome in large vessel occlusion stroke patients may be significantly improved if neurologists are supported by interpretable deep learning models.
Intracranial Atherosclerotic Plaque Morphologic Pattern and Enhancement Change With High‐Intensity Statin Therapy
Authors: Sanchez Sebastian , Miller Jacob M. , Jones Matthew T. , Ojeda Diego J. , Samaniego Edgar A. 
Published: June 2023

BackgroundPlaque enhancement after gadolinium contrast administration may assess plaque instability and response to medical therapy. We used high‐resolution vessel wall imaging to evaluate changes in plaque morphologic pattern and enhancement after treatment with high‐intensity statins.MethodsPatients with a history of stroke or transient ischemic attack attributable to intracranial atherosclerotic disease underwent 7‐T high‐resolution vessel wall imaging. T1 and T1+gadolinium sequences were obtained at baseline. Follow‐up images were acquired at a minimum of 6 months after the initial scan. Low‐density lipoprotein levels were also recorded at baseline and at follow‐up, after maximal medical therapy was started. Plaque burden, degree of stenosis, and area degree of stenosis were calculated at baseline and follow‐up. Gadolinium enhancement was quantified using a 3‐dimensional pipeline for plaque analysis.ResultsFive patients were included. The mean age was 56 years, and the average time to follow‐up imaging was 17.7 months. Low‐density lipoprotein decreased from a mean of 122 to 111 mg/dL at follow‐up. Plaque burden decreased from μ=76% to 60%, area degree of stenosis decreased from μ=61% to 56%, and gadolinium uptake decreased from a mean of μ=4.11 to 3.76. Furthermore, a lower low‐density lipoprotein at follow‐up was correlated with decreased plaque burden (r=0.86), lower area degree of stenosis (r=0.8), and less gadolinium uptake (r=0.82).ConclusionsPlaque morphologic pattern and gadolinium uptake changed at follow‐up with high‐intensity statin therapy. High‐resolution vessel wall imaging shows promise in assessing plaque response to medical therapy.
Counterfactual History: Three Worries and Replies
Authors: Zhao Helen 
Published: June 2023

Abstract
This article aims to shed light on what lies at the heart of skepticism towards counterfactual, alternative, or what-if history. On its face, counterfactual history gives historians and philosophers good reason to worry. First, because counterfactual pasts leave no traces, historians lack an important source of empirical warrant. Second, because rewriting historical events might unpredictably change the past, inferences about what might have happened seem only weakly supported by generalizations about what actually did happen. Third, counterfactual narratives appear especially vulnerable to wishful thinking. Ultimately, through consideration of the epistemic values that regulate the construction of counterfactual narratives, I marshal arguments against these objections and defend the legitimacy of the project. Still, I hope to show that far from being a mere ‘parlor game’, counterfactual history raises deep and provocative questions about historians’ ability to know our past, only some of which I address here.
Culture’s Impact on the Historical Sciences
Authors: Perkins T.J. 
Published: June 2023

Abstract
In this paper I introduce the thesis of cultural readiness about science found in the historical analysis of the Alvarez impact hypothesis of the end-Cretaceous mass extinction. Cultural readiness posits that in some scientific domains, there are scientifically apt questions, methodologies or theories that are only developed, considered, and adopted by a scientific community once some combination of empirical and cultural factors obtains within and without that domain. I demonstrate that 21st century philosophy of the historical sciences has been motivated by a commitment to legitimization and has prioritized epistemic ingenuity and has not addressed cultural readiness. I then argue that one vehicle for cultural readiness in the historical sciences is their use of narrative explanatory forms. Narratives offer an arena to blend cultural and empirical phenomena by their characteristic elicitation of familiarity and emotionality.
Narrative Explanation and Non-Epistemic Value
Authors: Turner Derek D. , AboHamad Ahmed 
Published: June 2023

Abstract
Explanations in the natural historical sciences often take the form of stories. This paper examines two accounts of the sources of narrative’s explanatory power: Beatty’s suggestion that narrative explanation is closely connected to historical contingency, and that narratives explain by contrasting what happened with what might have happened; and Ereshefsky and Turner’s view that narratives explain by organizing events around a central subject with a distinctive direction of historical development. In both accounts, it turns out that non-epistemic values typically play a role in the construction of narrative, and hence contribute to narrative’s explanatory force. Two case studies from historical science – the plate tectonic story of the Avalonian terrane, and the story of the evolution of trichromatic vision in (some) mammals – help to motivate and illustrate this argument.
Narrating Cultural Displacement and (Dis)Locating Beur Identity in Fouad Laroui’s De Quel Amour Blessé
Authors: Baba Nouzha 
Published: June 2023

Abstract
In this article, I analyse the prominent Moroccan-French author, Fouad Laroui’s novella De quel amour blessé (What Wounded Love, 1998) which narrates a story of an intercultural love affair in the diaspora, shaped in-between France and Morocco. This tragicomedy romance story, maps migrants’ cultural displacement and identity (re)construction. I look into how Maghrebian migrants’ French-born youths, known as the Beur generation, plot transcendent cultural and national routes of belonging. Through the protagonist’s case, the son of Moroccan migrants, the novella unfolds how postcolonial Maghrebian migration in France has engendered an intercultural and relational identity that belongs to different cultural subjectivities. It suggests a deconstruction of the idea that migrants’ identity are inextricably linked to a fixed culture, time and place, and instead, stresses identity as a process of becoming. Laroui’s narrative is a productive literary form of self-representation, of contesting homeland roots, (re)deconstructing identity and mapping intercultural attachments of belongings.
Speculative Cartographies
Authors: Mushaandja Nashilongweshipwe 
Published: June 2023

Abstract
There are far too few studies on Namibian art and artists in the diaspora. In response to this, I look at the work of Herman Mbamba, Jackson Wahengo and Shishani Vranckx. Mbamba is a visual artist based in Haugesund, Norway while musicians Wahengo and Vranckx are based in Copenhagen, Denmark and Amsterdam, The Netherlands, respectively. I offer an aesthetic reading, unpacking their work as counter-hegemonic maps, that signal the places of imagining otherwise. Wahengo and Vranckx’s songs lean towards national cultural memory while Mbamba’s abstract and figurative paintings conceal everyday realities. The concept of speculative cartography is applied, to read how these artists as African Diasporic subjects, speak to historic displacements and scatterings, while orientating themselves within national cultural memory that goes beyond ‘Namibianess’ or the African Diaspora. I argue that the speculative cartographies generate Thirdspaces that collapse binaries between settled and unsettled, imaginable and unimaginable, material and metaphysical spaces.
Paul Choart de Buzanval: A Learned French Ambassador and the Republic of Letters
Authors: De Smet Ingrid A. R. 
Published: June 2023

Abstract
Although he enjoys some renown as a friend of Joseph Scaliger and Isaac Casaubon, Henri iv’s ambassador to the United Provinces, Paul Choart de Buzanval (1551–1607) has rarely been studied in his own right since the 1960s. Yet Choart was a significant champion of the protestant cause, who built a network of contacts spread across Europe, from Venice over Germany to England. This article assesses, first, how Buzanval’s network grew as his career evolved during the final decades of the French Wars of Religion and their immediate aftermath. Secondly, it takes stock of Buzanval’s role as an early modern emissary abroad: it demonstrates how, over and above his diplomatic agency for Henri de Navarre/Henri iv, Buzanval also emerged as a patron and cultural intermediary with the – mostly protestant – Republic of Letters. Thus, from relatively modest beginnings, Buzanval became a notable player in a network that encompassed political as well as intellectual and merchant spheres.
The Missing Link: Modeling Readers of Multilingual Writing
Authors: Grutman Rainier 
Published: June 2023

Abstract
This contribution tries to fill the gap concerning the place and role of readers in multilingual studies by focusing on the ways in which multilingual texts both do and do not create multilingual readers. Three scenarios are illustrated with two examples each. So-called ‘shared multilingualism’ implies bilingual competence (and excludes monolingual readers) by juxtaposing languages with little overlap. Other texts exhibit more than one language yet construct a monolingual reader, while others still reward bilingual competence and at the same time accommodate monolingual incompetence.
Reactionary Multilingualism: Ezra Pound’s “Addendum for C”
Authors: Grønlie Espen 
Published: June 2023

Abstract
This article suggests a solution to the paradox that Ezra Pound both embraced literary multilingualism and endorsed ethnic segregation. The evident multilingualism of Pound’s poetry might tempt one into imagining that he was celebrating multilingualism as a societal fact. Focusing on Pound’s multilingual canto fragment “Addendum for C,” the article argues that this cannot possibly have been the case, and that a similar premise is too often taken for granted in contemporary studies of literary multilingualism.
Balkan, Creole, Other: Dislocating Contemporary Multilingualisms
Authors: Selimović Ena 
Published: June 2023

Abstract
Reading the language memoirs of Jhumpa Lahiri and Dubravka Ugrešić, this article investigates what it means to know or not know a language, particularly when that language is marked ‘foreign.’ The texts under analysis attend to languages that often fall under the rubric of ‘other languages’ and underexamined contact zones. Approaching the sociopolitical dominance of so-called global English and the literary marketplace of world literature, this article reveals the need to elaborate the concept of multilingualism through multiscalar reading practices that show the inter-imperial history of contemporary multilingualism.
Post-monolingual Anglophone Novels
Authors: Neumann Birgit 
Published: June 2023

Abstract
A range of recent anglophone novels is committed to weaving connections between English and other languages, thus turning English into a language of encounter. Activating both multilingual and translingual configurations, these novels are what one might—in line with Yasemin Yildiz (2012)—call “post-monolingual.” Post-monolingual novels are powerful expressions of the plurality of languages that coexist within seemingly homogeneous spaces. Fluidizing the boundaries between languages, these novels pose intricate challenges for literary studies, which concern all major dimensions of the literary text, that is, its poetics, its modes of reading, and the logic of publishing. The article explores the complexities at the heart of post-monolingual novels, offering close readings of Yvonne Adhiambo Owuor’s The Dragonfly Sea (2019) and Karina Lickorish Quinn’s The Dust Never Settles (2021).
Towards Understanding Small Cities: Zero Mile Series
Authors: Alam Mahtab 
Published: June 2023

Sanjay Kundan, Zero Mile Patna (Hindi), New Delhi, Vaam Prakashan, 2021, 148 pp., ₹250, ISBN 9789392017025 (Paperback). Bhuvendra Tyagi, Zero Mile Meerut (Hindi), New Delhi, Vaam Prakashan, 2022, 156 pp., ₹250, ISBN 9789392017025 (Paperback). Jai Singh, Zero Mile Aligarh (Hindi), New Delhi, Vaam Prakashan, 2023, 139 pp., ₹250, ISBN 978-93-92017-08-7 (Paperback).
High prevalence of food insecurity in peri-urban communities in Karachi, Pakistan: The flood aftermath
Authors: Haider Kaniz Amna , Surani Zoya , Khalid Ayesha , Jaffar Zaidi Syed Ali , Chohan Rumassah , Hoodbhoy Zahra 
Published: June 2023

Background Food insecurity (FI) is at a steep risk, especially in low middle-income countries. FI is further compounded in areas that experience environmental and economic instability, thus a reassessment in such critical times is required for burden estimation and to propose targeted interventions. Aims The objectives of this study were to assess the prevalence of, and sociodemographic factors associated with FI, as well as the coping strategies utilized in response to FI in peri-urban communities in Karachi, Pakistan. Methods We conducted a cross-sectional survey from November-December 2022 on 400 households in four peri-urban communities in Karachi, Pakistan. The Household Food Insecurity Access Scale (HFIAS) and reduced Coping Strategies Index (rCSI) questionnaire were used to assess FI. A Poisson regression was used to assess associations between sociodemographic factors and FI. Results The overall prevalence of FI was found to be 60.2% ( n = 241) of which 33.8% ( n = 135) were severely food insecure. Age, women's and breadwinners’ education, women's occupation, and parity were significantly associated with FI. Participants reported relying on less expensive foods (44%) and borrowing food or help from others (35%) as the most common coping strategies overall in the FI households. Conclusion With more than half the households facing FI and adopting severe measures to cope in these communities, it is pivotal to design and test interventions that can withstand economic and climate catastrophes and help ensure a safety need for food security for the most vulnerable.
Radiomics model based on intravoxel incoherent motion and diffusion kurtosis imaging for predicting histopathological grade and Ki-67 expression level of soft tissue sarcomas
Authors: Zhu Yi-feng , Li Yu-shi , Zhang Yu , Liu Ya-jie , Zhang Yi-ni , Tao Juan , Wang Shao-wu 
Published: June 2023

Background Accurate identification of the histopathological grade and the Ki-67 expression level is important in clinical cases of soft tissue sarcomas (STSs). Purpose To explore the feasibility of a radiomics model based on intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and diffusion kurtosis imaging (DKI) MRI parameter maps in predicting the histopathological grade and Ki-67 expression level of STSs. Material and Methods In total, 42 patients diagnosed with STSs between May 2018 and January 2020 were selected. The MADC software in Functool of GE ADW 4.7 workstation was used to obtain standard apparent diffusion coefficient (ADC), D, D*, f, mean diffusivity, and mean kurtosis (MK). The histopathological grade and Ki-67 expression level of STSs were identified. The radiomics features of IVIM and DKI parameter maps were used as the dataset. The area under the receiver operating characteristic curve (AUC) and F1-score were calculated. Results D-SVM achieved the best diagnostic performance for histopathological grade. The AUC in the validation cohort was 0.88 (sensitivity: 0.75 [low level] and 0.83 [high level]; specificity: 0.83 [low level] and 0.75 [high level]; F1-score: 0.75 [low level] and 0.83 [high level]). MK-SVM achieved the best diagnostic performance for Ki-67 expression level. The AUC in the validation cohort was 0.83 (sensitivity: 0.83 [low level] and 0.50 [high level; specificity: 0.50 [low level] and 0.83 [high level]; F1-score: 0.77 [low level] and 0.57 [high level]). Conclusion The proposed radiomics classifier could predict the pathological grade of STSs and the Ki-67 expression level in STSs.
Rôle du branding interne dans la transformation sociétale de la marque
Authors: Regany Fatima , Longo Cristina 
Published: June 2023

Résumé La recherche a étudié le contexte organisationnel nécessaire au développement de marques durables sans explorer comment leur transformation s’opère. En adoptant le cadre conceptuel du branding interne, nous étudions la transformation sociétale de la marque gérée par les acteurs internes et les enjeux émergeants. Une étude qualitative révèle des dynamiques de collaboration et de tension entre responsables RSE et marketing, donnant lieu à la co-création de marques durables et visant un positionnement RSE. La figure de l’ activiste, leader œuvrant pour faire de ses collègues des champions de marque en transition vers la durabilité, émerge. En connectant marketing interne et externe, des contradictions alimentent les dilemmes de la marque : communication transparente contre silence opaque, confiance en soi contre doute. Nos apports théoriques s’inscrivent en branding interne, co-création de marque et complexités des marques durables. Des recommandations visant à gérer en interne et à accélérer la transformation sociétale des marques sont proposées.
Tanshinone IIA inhibits ischemia-reperfusion-induced inflammation, ferroptosis and apoptosis through activation of the PI3K/Akt/mTOR pathway
Authors: Zhang Rui , Liu Yunen , You Jihui , Ge Baiping 
Published: June 2023

Ischemia-reperfusion (I/R) is a common clinical process, and the lung is one of the most sensitive organs of I/R injury, which often leads to acute lung injury (ALI). Tanshinone IIA (Tan IIA) has anti-inflammatory, antioxidant, and anti-apoptotic activities. However, the effects of Tan IIA on lung I/R injury remain uncertain. Twenty-five C57BL/6 mice were randomly divided into five groups: control (Ctrl), I/R, I/R + Tan IIA, I/R + LY294002 and I/R + Tan IIA + LY294002 group. Tan IIA (30 μg/kg) was injected intraperitoneally 1 h before injury in the I/R + Tan IIA and I/R + Tan IIA + LY294002 groups. These data showed that Tan IIA significantly improved I/R-induced histological changes and scores of lung injury, decreased lung W/D ratio, MPO and MDA contents, reduced infiltration of inflammatory cells, and decreased the expression of IL-1β, IL-6 and TNF-α. Meanwhile, Tan IIA significantly increased the expression of Gpx4 and SLC7A11, and decreased the expression of Ptgs2 and MDA. Moreover, Tan IIA significantly reversed the low expression of Bcl2, and the high expression of Bax, Bim, Bad and cleave-caspase 3. Furthermore, Tan IIA caused a significant increase in the phosphorylation levels of PI3K, Akt and mTOR in the lungs. However, these beneficial effects of Tan IIA on I/R-induced lung inflammation, ferroptosis and apoptosis were offset by LY294002. Our data suggest that Tan IIA significantly ameliorates I/R-induced ALI, which is mediated through activation of PI3K/Akt/mTOR pathway.