bluuebunny/crossref_metadata_2025_split huggingface dataset:
Up-regulation of Myocardial Klotho Expression to Promote Cardiac Functional Recovery in Old Mice following Endotoxemia
Authors: Li Xueting , Zhai Yufeng , Yao Qingzhou , The Erlinda , Ao Lihua , Fullerton David A. , Yu Kai-Jiang , Meng Xianzhong 
Published: May 2023

Abstract
Objective: Endotoxemic cardiac dysfunction contributes to greater morbidity and mortality in elderly patients with sepsis. This study tested the hypothesis that Klotho insufficiency in aging heart exaggerates and prolongs myocardial inflammation to hinder cardiac function recovery following endotoxemia.
Methods:Endotoxin (0.5 mg/kg, iv) was administered to young adult (3-4 months) and old (18-22 months) mice with or without subsequent treatment with recombinant interleukin-37 (IL-37, 50 µg/kg, iv) or recombinant Klotho (10 µg/kg, iv). Cardiac function was analyzed using a microcatheter 24, 48 and 96 h later. Myocardial levels of Klotho, ICAM-1, VCAM-1 and IL-6 were determined by immunoblotting and ELISA.
Results: In comparison to young adult mice, old mice had worse cardiac dysfunction accompanied by greater myocardial levels of ICAM-1, VCAM-1 and IL-6 at each time point following endotoxemia and failed to fully recover cardiac function by 96 h. The exacerbated myocardial inflammation and cardiac dysfunction were associated with endotoxemia-caused further reduction of lower myocardial Klotho level in old mice. Recombinant IL-37 promoted inflammation resolution and cardiac functional recovery in old mice. Interestingly, recombinant IL-37 markedly up-regulated myocardial Klotho levels in old mice with or without endotoxemia. Similarly, recombinant Klotho suppressed myocardial inflammatory response and promoted inflammation resolution in old endotoxemic mice, leading to complete recovery of cardiac function by 96 h.
Conclusion: Myocardial Klotho insufficiency in old endotoxemic mice exacerbates myocardial inflammatory response, impairs inflammation resolution and thereby hinders cardiac functional recovery. IL-37 is capable of up-regulating myocardial Klotho expression to improve cardiac functional recovery in old endotoxemic mice.
Three plant- and animal-based dietary patterns and their relationship to serum uric acid levels
Authors: Mao Danhui , Feng Jin , Zhou Yangzilin , Li Honggang 
Published: May 2023

Abstract
Background
Dietary patterns play an important role in the development of hyperuricemia and gout, but evidence for the association between different kinds of plant-based and animal-based dietary patterns and individual serum uric acid levels is scarce and inconsistent.
Methods
We analyzed data from the sixth wave of the China Health and Nutrition Survey. The plant-based diet of 7,806 participants was determined using three consecutive 24-hour dietary recalls, and latent profile analysis was used to identify dietary patterns among participants. Serum uric acid levels were analyzed using the enzymatic colorimetric method. The association between intakes of different types of dietary pattern and individual serum uric acid levels was analyzed using linear regression analysis, after adjusting for confounding variables.
Results
We identified three types of plant-based dietary patterns, namely, low tuber starches and vegetable plant-based diet (LTVP), high cereal, tuber starches and vegetable plant-based diet (HCTVP), and high legume and fruit plant-based diet (HLFP). We also identified three types of animal-based dietary patterns, namely, high milk and egg animal-based diet (HMiEA), low egg and fish animal-based diet, and high meat and fish animal-based diet (HMeFA). Significant coefficients for participant serum uric acid levels were observed for the HCTVP diet (β = −0.022, P = 0.031) and HMeFA diet (β = 0.061, P < 0.001). The median intake of foods in the HCTVP diet was as follows: cereals and cereal products, 444.83 g/d; tubers and starch products, 166.67 g/d; dried legumes and legume products, 8.33 g/d; vegetables and vegetable products, 333.33 g/d; and fruits and fruit products, 0 g/d. The median intake of foods in the HMeFA diet was as follows: meat and meat products, 73.33 g/d; poultry and poultry products, 0 g/d; milk and milk products, 0 g/d; eggs and egg products, 26.67 g/d; and fish, shellfish, and mollusks, 180.00 g/d.
Conclusion
We showed that individual serum uric acid levels (1) might decrease under the plant-based HCTVP diet, (2) might increase under the animal-based HMeFA diet, (3) might not decrease under the plant-based HLFP diet, and (4) might not increase under the animal-based HMiEA diet. Further studies are needed to confirm these associations.
The Relationship Between Systemic Inflammation Index, Systemic Immune-Inflammatory Index, and Inflammatory Prognostic Index and 90-Day Outcomes in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
Authors: Ma Fei , Li Lulu , Xu Liang , Wu Jiacheng , Zhang Aimei , Liao Junqi , Chen Jingyi , Li Yunze , Li， Li , Chen Zhaoyao , Li Wenlei , Zhu Qing , Zhu Yuan , Wu Minghua 
Published: May 2023

Abstract
Background and purpose
This study aimed to explore the association between the systemic inflammatory index (SIRI), systemic immune-inflammatory index (SII), and inflammatory prognosis index (IPI) with the 90-day outcomes of patients with acute ischemic stroke (AIS) after intravenous thrombolysis.
Methods
190 AIS patients who underwent intravenous thrombolysis from September 2019 to December 2022 were enrolled in the present study. The National Institutes of Health Stroke Scale (NIHSS) and modified Rankin score (mRS) were assessed in AIS patients who met the inclusion criteria before thrombolysis, immediately after thrombolysis, and at 90 days. Peripheral venous blood was collected within 24 hours after admission and used to assess the following parameters: neutrophil count, lymphocyte count, monocyte count, platelet count, average platelet volume, and albumin. Next, the SIRI, SII, and IPI values were calculated, respectively. The correlation among SIRI, SII, IPI, and admission NIHSS scores was examined by Spearman correlation analysis. ROC curve analysis was conducted to determine the optimal cut-off value of SIRI, SII, and SIRI and their corresponding sensitivity and specificity to evaluate their predictive value on admission for poor prognosis. To investigate whether high SIRI, SII, and IPI were independent predictors of poor outcomes within 90 days, variables with P-value < 0.05 during univariate analysis were included in multivariate analysis.
Results
Compared with the good outcome group, the poor outcome group had higher age, baseline NIHSS, neutrophil count, mRS, NLR, SIRI, IPI, and SII, while the lymphocyte count was lower. Spearman correlation analysis showed that the SIRI, IPI, and SII levels significantly correlated with the admission NIHSS score (r = 0.338, 0.356, 0.427, respectively; Ps < 0.001). The Mann-Whitney U test showed that the SIRI, SII, and IPI levels in patients with moderate and severe AIS were higher than in patients with mild AIS (P < 0.001). Univariate analysis showed that admission NIHSS, NLR, SIRI, SII, and IPI were significantly correlated with poor 90-day prognosis. Although age, smoking and drinking history, and underlying diseases were not significantly associated with prognosis, they were considered potential risk factors for AIS and included in the analysis as potential confounding factors. Using the optimal cut-off value determined by ROC analysis, multivariate logistic regression analysis revealed high SIRI, SII, and IPI values as independent risk factors for poor 90-day prognosis (OR = 2.867, 3.721, and 2.877, respectively).
Conclusions
High SIRI, IPI, and SII values are correlated with poor 90d outcomes in AIS patients undergoing intravenous thrombolysis.
Neoadjuvant chemoradiotherapy followed by minimally invasive esophagectomy for borderline resectable esophageal squamous cell carcinoma; A retrospective cohort study with short- and mid-term oncological outcomes
Authors: Hosogi Hisahiro , Yoshida Shinya , Sakaguchi Masazumi , Kanaya Seiichiro 
Published: May 2023

Abstract
Background
The best treatment strategy for borderline resectable locally advanced esophageal squamous cell carcinoma (ESCC) is unknown. Although neoadjuvant chemoradiotherapy (NACRT) provides good local control, the subsequent surgery is complicated by edema or fibrosis, particularly in minimally invasive esophagectomy (MIE). This retrospective cohort study sought to assess the feasibility of NACRT followed by MIE for borderline resectable ESCC.
Methods
Consecutive patients who underwent NACRT (40Gy radiotherapy with chemotherapy of 5-FU and Cisplatin) followed by MIE with gastric tube reconstruction for locally advanced ESCC were included. Following a review of pretreatment CT by 2 independent physicians, clinically borderline resectable T3 (cT3br) tumors were chosen, with resectable (cT3r) and unresectable (cT4b) tumors excluded. The short- and mid-term oncological outcomes were assessed.
Results
Patients with 33 cT3br tumors were included. There was no postoperative mortality, and 11 and 7 patients had postoperative Clavien-Dindo Grade ≥ II and Grade ≥ III complications, respectively. R0 resection was achieved in 32 patients, with 4 patients showing pathological complete response. With a median follow-up of 675 days, 15 patients had relapsed, the majority of which included distant metastasis, and only one patient had a pure locoregional recurrence. Patients who experienced postoperative complications had significantly lower relapse-free survival (RFS) than those who did not (p = 0.049) (2-year RFS: 0% and 65%, respectively).
Conclusions
NACRT followed by MIE for cT3br tumors was feasible with adequate R0 resection rates. Although locoregional control was adequate, distant metastasis was poorly controlled. MIE with fewer postoperative complications would provide better oncological results.
Genes encoding vascular cambium activity of Eucalyptus urophylla × Eucalyptus grandis revealed by transcriptomic analyses
Authors: Liu Guo , Wu Zhihua , Luo Jianzhong , Wang Chubiao , Shang Xiuhua , Zhang Guowu 
Published: May 2023

Abstract
Background: Vascular cambium activities mainly include cambium proliferation and vascular tissue formation through secondary growth, thereby producing new secondary phloem inward and secondary xylem outward and leading to continuous tree thickening and wood for-mation. Therefore, the analysis of the molecular mechanism underlying wood vascular cambium activities can lead to the identification of both key and related genes involved in the for-mation, development, and differentiation of vascular cambium.
Results: In the present study, RNA-Seq and Pac-Bio Iso-Seq were used for profiling gene expression changes in Eucalyptus urophylla × E. grandis (E. urograndis) vascular cambium at four different ages. A total of 59,770 non-redundant transcripts and 1892 differentially expressed genes (DEGs) were identified. The expression trends of the DEGs related to cell division and differentiation, cell wall biosynthesis, phytohormone, and transcription factors were analyzed. The DEGs encoding expansin, kinesin, cycline, PAL, GRP9, KNOX, C2C2-dof, REV, etc., were highly expressed in E. urograndis at three years old, leading to positive effects on growth and development. Moreover, some gene family members, such as NAC, MYB, HD-ZIP III, RPK, and RAP, play different regulatory roles in vascular cambium activity because of their sophisticated transcriptional network and function redundantly.
Conclusions: These candidate genes are a potential resource to further study vascular cambium activity, espe-cially in fast-growing and adaptable eucalyptus. The results may also serve as a basis for further research to unravel the molecular mechanism underlying wood formation.
Arabidopsis phyB functions as a green light photoreceptor to promote photomorphogenesis
Authors: Xu Miqi , Wu Yujie , Tao Kunying , Wang Xuncheng , Wang Yi-Yuan , Li Jian , Wu Qingqing , Ling Jun-Jie 
Published: May 2023

Abstract
Although green light (GL, 500–600 nm) occupies half the visible light spectrum and regulates a series of plant developmental processes, the mechanism by which GL regulates seedling morphogenesis is enigmatic. Here, we reported that pure GL (500–600 nm, λmax, 527 nm) promoted the cotyledon development of Arabidopsis seedlings through phytochrome B (phyB). Genetic analysis indicated that phyB was involved in cotyledon development under continuous GL. Compared with red light (RL), GL induced phyB translocation from the cytoplasm to the nucleus and speckle-like photobody formation with a slower rate, which was reversed by far red light. Further transcriptomic data demonstrated that phyB participated in GL-responsive transcriptional networks in concert with four PHYTOCHROME-INTERACTING FACTORS (PIFs, PIF1, PIF3, PIF4, and PIF5). As expected, protein levels of the PIFs were decreased by GL. Similar to RL, GL induced the rapid degradation of PIF3 in a phy-dependent manner. Our results suggest that pure GL (527 nm) leads to the migration of phyB into the nucleus to trigger photomorphogenesis by possibly promoting the degradation of PIFs.
Hotspots and Frontiers of Congenital Biliary Dilatation: A Bibliometric Analysis from 1990 to 2022
Authors: Zheng Chen , Ye Shiru , Zhang Yifan , Diao Mei , Li Long 
Published: May 2023

Abstract
Background
Congenital biliary dilatation (CBD) is a rare malformation in the development of the biliary duct. Since 1990, there have been significant advancements in CBD research and substantial changes in treatment methods. This study aims to identify and evaluate global trends in CBD research over the past 30 years, as well as visualize research hotspots and potential frontiers through bibliometric analysis.
Methods
This study conducted a comprehensive search of CBD articles published from January 1990 to December 2022 in the Web of Science Core Collection database. Visual analysis was performed on the countries, research institutions, authors, keywords, and research frontiers included in the articles using CiteSpace and VOSviewer software.
Results
A total of 1794 articles were published, and the overall number of articles showed an upward trend. The United States, Japan, and China are the top three countries in terms of article output. Juntendo University has the highest number of publications. Li Long, Miyano Takeshi, and Cheng Wei are the top three researchers in terms of publication volume. Co-occurrence analysis of keywords shows that "choledochal cyst", "management", and "children" are the three most important keywords. Keyword co-occurrence forms 19 clusters, and burst citation analysis (2013–2022) identifies 13 cutting-edge keywords. CBD research hotspots mainly focus on diagnosis, minimally invasive surgery, and carcinoma.
Conclusions
This study employs bibliometric analysis to examine the literature on CBD from 1990 to 2022, revealing the development and changes in the field of CBD, identifying three main research hotspots, and exploring potential research frontiers. The findings of this study offer valuable references for researchers in the field of CBD.
Study on Creep Damage Model of Yellow Sandstone with Step Loading and Unloading under the Action of Wetting-drying Cycles
Authors: Qin Zhe , Liu Yongde , Pang Wenlong , Han Jihuan , Liu Wenlong , Feng Qiang 
Published: May 2023

Abstract
This study performs uniaxial compression and step loading and unloading creep tests on rock samples under different wetting-drying cycles with yellow sandstone to investigate the creep characteristics of rock bodies after excavation or excavations with step loading and unloading under external forces. Moreover, it constructs a creep damage model based on the nonlinear rheological theory and damage mechanics to describe the instantaneous elastic strain, instantaneous plastic strain, nonlinear viscoelastic strain, and nonlinear viscoplastic strain of rocks. Besides, it proposes a creep model parameter identification method based on the creep curve characteristics. The results have shown that the action of wetting-drying cycles causes a weakened decrease in elastic modulus, uniaxial compressive strength, and long-term compressive strength of yellow sandstone, in line with the exponential function change relationship. The specimen damage type evolves from shear damage of a single oblique section to conical shear damage of a double oblique section. Additionally, the creep rate is not constant in the steady-state creep stage but constantly changes with time, and the fluctuation range increases with the increase in the wetting-drying cycles. The creep damage model parameters Eme, Emp, Eve, and ηve do not differ much under the same stress condition, and each parameter is influenced by the creep stress σ at a specific law. The Eme, Emp, and σ have a linear relationship, whereas the Eve, ηve, and σ have an exponential one.
Colloidal NafionTM particles: Are Cylinders Ubiquitous?
Authors: Klein Jeffrey M. , Welch Cynthia , Ponnurangam Sathish , Tarokh Atefeh , Karan Kunal , Hawley Marilyn E. , Sokolova Anna , Yim Sung-Dae , Hjelm Rex P. , Kim Yu Seung 
Published: May 2023

Abstract

Colloidal NafionTM morphology plays a critical role in determining the performance of fuel cells and electrolyzers. While previous small angle neutron scattering (SANS) studies described NafionTM in liquid media as dispersed cylinders, the analysis remains non-unique with multiple possible morphological descriptions of the data. Here, we show that NafionTM morphology in liquid media differs substantially from the previously described morphology. SANS and all-atomistic molecular dynamics simulation studies indicate NafionTM dispersed in N-methyl pyrrolidone as swollen cluster particles with physically cross-linked ionic groups. NafionTM dispersion in water has a highly elongated cylindrical morphology (radius = 10 ± 1.5 Å, height = 358 ± 4.7 Å) with fully dissociated and solvated sulfonic acid groups on the particle wall. Our approach describes precise NafionTM particle morphology and chain conformation, which opens a new horizon on the tailored interface design of NafionTM for fuel cells and electrolyzers.
Quantized wrinkle and fracture of stiff membrane on soft film
Authors: Meng Yancheng , Xiang Henggao , Zhang Jianqiang , Hu Zhili , Yin Jun , Li Liqiang , Zhang Zhuhua , Guo Wanlin 
Published: May 2023

Abstract
Stiff membranes on soft substrates tend to wrinkle under compression1–11. The evolution of post-wrinkle instability through wrinkling3,12, period doubling to quadruple folds, and/or creases4,9,11 with increasing compression has been extensively studied, but how to control this intriguing evolution remains challenging. Here, we obtain a scaling law for wrinkle evolution in which a single parameter, consisting of thickness contrast of the soft film to the stiff membrane and a material constant, determines the final instability order of the wrinkle evolution. In sharp contrast to the common view that the thickness effect of soft substrate is negligible as the thickness contrast reaches a few tens, the soft film thickness plays a dominant role for thickness contrast across several orders of magnitude. The law proves to be universal in a sufficiently large range of materials and geometries, thus, should play a general role in controlling the complex behavior of natural and artificial stiff/soft bilayer systems.
Learning from Observations, a Bayesian Solution to the Secretary Problem
Authors: Sorkun Murat Cihan 
Published: May 2023

Abstract
The Secretary Problem is a well-known problem in optimal stopping theory that aims to determine the best strategy for selecting the best option from a pool of candidates. In this study, we focused on three sub-cases of the standard version of the Secretary Problem, which vary based on the availability of candidates' scores: no-information, full-information, and partial-information. First, we validated the existing theoretical solutions by conducting Monte Carlo simulations on generated data for the no-information and full-information cases which constitute the lower (0.37) and the upper (0.58) limits of the win rate, respectively. Then, we developed a Bayesian solution for the partial-information case which continuously learns the distribution of the scores from the interviewed candidates. The simulation results for the proposed solution showed that it is possible to reach the upper win rate limit without knowing any prior information about the population. We also tested the solution on a real dataset (Dutch exam scores) and achieved 0.53 win rate. We expect the proposed algorithm will provide a better solution than the commonly used no-information solution (37% rule) for the real-life applications of the Secretary Problem.
Land-use and land-cover change and its impact on flood hazard occurrence in Wabi Shebele River Basin of Ethiopia
Authors: Wudineh Fraol Abebe 
Published: May 2023

Abstract
Land-use and land-cover (LULC) changes can impact hydrological conditions such as land surface coefficient, runoff, and infiltration. This study investigates the changes in LULC and its impact on water resources of the Wabi Shebele basin using the soil and water assessment tool (SWAT) and a separation method. Surface and groundwater parameters in the northwestern; and soil and surface parameters in the eastern highland and southern lowland parts of the basin are identified as sensitive parameters in water production. The coverage of cropland was increased by 48.63% while forest and woodland decreased by 49.14 and 14.76%, respectively, between the 1980s and 2010. Streamflow simulated during this period indicates increases in those watersheds showing significant cropland increases and forest coverage decreases particularly in Wabi at Dodola, Maribo, Robe, and Erer watersheds. Flood indices (i.e., AMAX, SMW, SMSp, and SMSu) calculated from simulated daily streamflow under different LULC map indicates an increase in the middle and northwestern watersheds up to 1.83 and 0.44%, respectively. The impact level of LULC change on flood discharge shows a comparable level with climate change impact on flood hazard, particularly in the middle part of the basin.
To Explore the Putative Molecular Targets of Diabetic Nephropathy and their Inhibition Utilizing Potential Phytocompounds
Authors: Bhattacharjee Banani , Chakrovorty Arnob , Biswas Maharaj , Samadder Asmita , Nandi Sisir 
Published: May 2023

Background:This review critically addresses the putative molecular targets of Diabetic Nephropathy (DN) and screens effective phytocompounds that can be therapeutically beneficial, and highlights their mechanistic modalities of action.Introduction:DN has become one of the most prevalent complications of clinical hyperglycemia, with individual-specific variations in the disease spectrum that leads to fatal consequences. Diverse etiologies involving oxidative and nitrosative stress, activation of polyol pathway, inflammasome formation, Extracellular Matrix (ECM) modifications, fibrosis, and change in dynamics of podocyte functional and mesangial cell proliferation adds up to the clinical complexity of DN. Current synthetic therapeutics lacks target-specific approach, and is associated with the development of inevitable residual toxicity and drug resistance. Phytocompounds provides a vast diversity of novel compounds that can become an alternative therapeutic approach to combat the DN.Method:Relevant publications were searched and screened from research databases like GOOGLE SCHOLAR, PUBMED and SCISEARCH. Out of 4895 publications, the most relevant publications were selected and included in this article.Result:This study critically reviews over 60 most promising phytochemical and provides with their molecular targets, that can be of pharmacological significance in context to current treatment and concomitant research in DN.Conclusion:This review highlights those most promising phytocompounds that have the potential of becoming new safer naturally-sourced therapeutic candidates and demands further attention at clinical level.