bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein‐DNA Competition at the Bio‐Nano Interface: Structural and Biological Insights From Graphene Oxide Coronas
Authors: Quagliarini Erica , Giulimondi Francesca , Renzi Serena , Pirrottina Andrea , Zingoni Alessandra , Carboni Nicholas , Pozzi Daniela , Caracciolo Giulio 
Published: January 2025

AbstractUnderstanding interactions between nanomaterials and biomolecules is essential for advancing biomedical nanotechnologies. This study investigates how double‐stranded DNA of varying sizes affects the protein corona (PC) surrounding Graphene Oxide (GO) nanosheets in DNA‐supplemented human plasma. The findings reveal that DNA plays a pivotal role in modulating the PC composition through dynamic competition governed by factors like surface charge, affinity, and DNA fragment size. At lower DNA concentrations, competition between DNA and proteins for binding sites on GO leads to a corona predominantly composed of proteins, with some DNA molecules also bound. However, as the DNA concentration increases beyond a threshold, a shift occurs. DNA increasingly outcompetes proteins for binding sites, resulting in a two‐component corona enriched with both DNA and proteins. Notably, the proportion of DNA within the corona progressively increases with rising DNA concentration, while the protein content decreases. This dynamic interplay between DNA and proteins has significant biological implications. A monotonic increase in Toll‐like receptor 9 (TLR9) activation is observed as the DNA content within the corona increases. As the corona composition and its influence on cellular responses are crucial, this study emphasizes the relevance of exploring competition at the bio‐nano interface for the advancement of these applications.
Intramolecular Crossed [2+2] Cycloaddition through Visible‐Light Triplet Sensitization: Expedient Access to Bridged Bicyclic Alkene
Authors: Li Min , Tao Le‐Yi , Gu Xin‐Tao , Wei Yin , Shi Min 
Published: January 2025

AbstractA visible‐light‐induced intramolecular crossed [2+2] cycloaddition reaction of allene‐tethered alkylidenecyclopropanes was reported in this paper. The reactions were conducted under mild conditions using Iridium(III) catalyst FirPic as a photosensitizer for energy transfer, affording bridged bicyclic alkenes in moderate to good yields with excellent regioselectivity and stereoselectivity through the regulation of substituents at the olefin's terminal position. Meanwhile, the computational study explained the special region control assisted by sulfonyl radicals in detail.
An sp2 Carbon‐Conjugated Covalent Organic Framework for Fusing Lipid Droplets and Engineered Macrophage Therapy
Authors: Guan Qun , Zhou Le‐Le , Yang Zhiqing , Xie Beibei , Li Yan‐An , Wang Ruibing 
Published: January 2025

AbstractEngineered immune cell therapy has proven to be a transformative cancer treatment despite the challenges of its prohibitive costs and manufacturing complexity. In this study, we propose a concise “lipid droplet fusion” strategy for engineering macrophages. Because of the integration of hydrophobic alkyl chains and π‐conjugated structures, the mildly synthesized sp2C‐conjugated covalent organic framework (COF) UM‐101 induced lipid droplet fusion and metabolic reprogramming of macrophages, thus promoting their antitumor classical activation. Intravenous injection of UM‐101–engineered macrophages effectively inhibited tumor progression. These results represent the first report of room‐temperature synthesis of sp2C‐conjugated COFs for engineered immune cell therapy, providing a new perspective for the development of therapeutic immune cells via organelle manipulation.
Altermagnetism in NiSi and Antiferromagnetic Candidate Materials with Non‐Collinear Spins
Authors: Singh Deepak K. , Cheong Sang‐Wook , Guo Jiasen 
Published: January 2025

AbstractRecently, a new class of magnetic phenomenon, called altermagnetism, is proposed where the underlying spin configuration resembles antiferromagnetic structure, but the system violates PT (PT: Parity times Time reversal) symmetry due to the alternation of crystalline symmetry across magnetic ions. Although the original idea is proposed for the collinear spin structure, a recent report by Cheong et al. has suggested that antiferromagnetic materials with non‐collinear spin structure and local alternation of crystalline arrangement can also manifest altermagnetism. Besides breaking the PT symmetry, altermagnetic compounds are also expected to exhibit anomalous Hall effects of odd orders. Here, possible candidates are discussed in this regard. One example is nickel monosilicide, which is recently shown to exhibit high temperature antiferromagnetism with non‐collinear spin structure. It fulfills both criteria of breaking the PT symmetry and manifesting nonlinear anomalous Hall effect. In addition to NiSi, other potential antiferromagnetic materials are also discussed with non‐collinear spin configuration for the exploration of altermagnetic states.
Controllable Synthesis of Heterogeneous ZnS/SnS2 Encapsulated in Hollow Nitrogen‐Doped Carbon Microcubes as Anode for High‐Performance Li‐ion Capacitors
Authors: Liu Huandong , Zhu Zhengju , Demir Muslum , He Ying , Saha Petr , Cheng Qilin 
Published: January 2025

AbstractLi‐ion capacitors (LICs) integrate the desirable features of lithium‐ion batteries (LIBs) and supercapacitors (SCs), but the kinetic imbalance between the both electrodes leads to inferior electrochemical performance. Thus, constructing an advanced anode with outstanding rate capability and terrific redox kinetics is crucial to LICs. Herein, heterostructured ZnS/SnS2 nanosheets encapsulated into N‐doped carbon microcubes (ZnS/SnS2@NC) are successfully fabricated. The sufficient ZnS/SnS2 heterostructure possesses abundant active sites, and the built‐in electric field formed at the heterojunction interface can facilitate electron/ion migration. The interconnected hollow carbon layers could reduce the electron transfer resistance effectively and accommodate the volume change of SnS2, thereby maintaining the structural stability. Due to the synergy between multi‐components, the ZnS/SnS2@NC anode demonstrates impressive Li storage performance with an excellent cyclic durablity (690 mAh g−1 at 0.5 A g−1 after 600 cycles) and considerable rate capability. Moreover, when matched with active carbon, the ZnS/SnS2@NC based LIC device delivers an admirable energy density of 134.1 Wh kg−1 and a high power output of 11,250 W kg−1, as well as remarkable capacity retention of 73.2 % after 6,000 cycles at 1.0 A g−1. The experimental results demonstrate the significance of optimized heterointerface engineering toward construction of electrode materials with high‐performance for Li storage.
Radiofrequency Induced Time‐Dependent Alterations in Gene Expression and Apoptosis in Glioblastoma Cell Line
Authors: Tuysuz Mehmet Zahid , Kayhan Handan , Saglam Atiye Seda Yar , Senturk Fatih , Bagriacik Emin Umit , Yagci Munci , Canseven Ayse Gulnihal 
Published: January 2025

ABSTRACTThe widespread use of wireless communication technologies has increased human exposure to radiofrequency electromagnetic fields (RF‐EMFs). Considering the brain's close proximity to mobile phones and its entirely electrical transmission network, it emerges as the organ most profoundly impacted by the RF field. This study aims to investigate the potential effects of RF radiation on cell viability, apoptosis, and gene expressions in glioblastoma cells (U118‐MG) at different exposure times (1, 24, and 48 h). To achieve this, we designed and implemented an in vitro RF exposure system operating at a frequency of 2.1 GHz, specifically for cell culture studies, with an average specific absorption rate (SAR) of 1.12 ± 0.18 W/kg determined through numerical dosimetry calculations. Results reveal a significant influence of a 48 h exposure to a 2.1 GHz RF field on U118‐MG cell viability, gene expression, and the induction of caspase (CASP) dependent apoptosis. Notably, increased CASP3, CASP8, and CASP9 mRNA levels were observed after 24 and 48 h of RF treatment. However, only the 48 h RF exposure resulted in apoptotic cell death and a significant elevation in the BAX/BCL‐2 ratio. This observed effect may be influenced by extended exposure durations surpassing the cell's doubling time. The increased BAX/BCL‐2 ratio, which acts as a key switch for apoptosis, and the heterogeneous morphology of the astrocyte‐derived U118‐MG cell line may also play a role in this effect.
Poe or Gemini for fostering writing skills in Japanese upper‐intermediate learners: Uncovering the consequences on positive emotions, boredom to write, academic self‐efficacy and writing development
Authors: Wu Qiong , Xu Anfeng 
Published: January 2025

AbstractThe integration of AI‐based platforms, such as Poe and Gemini, into language instruction has garnered increasing attention for their potential to enhance writing skills. Despite this interest, little is known about their effects on EFL learners' positive emotions (PEs), academic self‐efficacy and boredom in writing. Addressing this gap, the present study investigated the effectiveness of Poe and Gemini in developing writing skills and explored their impact on learners' PEs, academic self‐efficacy and boredom among learners at the upper‐intermediate level. For this purpose, a total of 519 Japanese upper‐intermediate EFL learners were randomly assigned to three groups: (1) Poe‐assisted writing instruction; (2) Gemini‐assisted writing instruction; and (3) a control group (CG) receiving traditional instruction. The study employed a mixed‐methods design, incorporating both quantitative and qualitative data collection. Writing development was assessed through pre‐ and post‐tests, while learners' emotions, boredom and academic self‐efficacy were measured using validated scales. Additionally, qualitative data were gathered through interviews and analysed using coding and thematic analysis to understand learners' attitudes and perceptions. Quantitative data were analysed using ANOVA and MANOVA to compare the outcomes across the three groups. The findings revealed that both Poe and Gemini significantly improved learners' writing skills compared to the CG, with no substantial differences in effectiveness between the two platforms. Participants in the Poe and Gemini groups reported heightened PEs and increased academic self‐efficacy, alongside reduced boredom during writing tasks. The qualitative findings corroborated these results, highlighting the platforms' role in fostering greater enthusiasm, engagement, autonomy and motivation in English language learning. The study concludes by offering a range of implications for different stakeholders.
Acute Osmotic and pH Shock to Bioluminescent Bacteria Is Reversible in Terms of Luminescence Response
Authors: Ranjan Rajeev , Goswami Sakshi , Sharma Navendu , Vashishtha Lalit Mohan , Singh Meenu , Verma Yeshvandra , Rana Suresh Vir Singh , Kratasyuk Valentina , Kumar Satyandra , Pandey Archna 
Published: January 2025

ABSTRACTBioluminescence inhibition (BLI) measurements in bioluminescent bacteria (BB) is perceived as a potential qualitative and quantitative indicator of hazardous materials. Acute but minor fluctuations in osmolarity and pH do not affect the living systems significantly. However, significant BLI is observed from marine BB due to acute osmolarity or pH changes that may affect the bioassay sensitivity. Often, real samples have low pH and osmolarity, interfering with the hazard assessment based on the principles of BLI. This anomaly in BLI measurements may lead to false positives. Therefore, modifications in existing analytical methods to overcome such practical constraints are envisaged. In the present research, a marine BB was utilized to study the luminescence reversal effect when exposed to stressful environments such as hypotonic (deionized water), acidic (50 μM to 50 mM HCl), and 0.1–100 ppm of Hg(II) for 0–30 min. Postincubation, the calcium alginate immobilized bioluminescent bacteria (biophotonic beads) were transferred to Boss media to observe any luminescence enhancement. The results showed that osmotic shock and low‐strength acidic environments (50 μM to 0.5 mM HCl) at specified incubation times were not detrimental to the biophonic beads regarding luminescence response.
Technology Adoption Intention and Sustainable Entrepreneurship Ability of Rural Women in Bangladesh
Authors: Sarker Tanwne , Roy Rana , Yeasmin Sabina , Rabbany Md. Ghulam , Asaduzzaman Muhammad 
Published: January 2025

ABSTRACTThe expansion of women entrepreneurs in Bangladesh is essential for economic development, primarily driven by the use of Information and Communication Technology (ICT). This expansion is more noticeable in urban areas, generating a research gap to find out the adoption of ICT among rural women entrepreneurs. Our present study seeks to identify the factors influencing ICT adoption intentions among women entrepreneurs in rural Bangladesh. Data from 315 respondents were collected and analyzed utilizing partial least squares‐structural equation modeling through Smart PLS 3.3v software. Our results reveal that women's utilization of ICT is positively associated with their access to material, mental, skill, usage, and ICT in microfinance. This adoption significantly upgrades the business skills of rural Bangladeshi women, offering essential insights for future entrepreneurs. Our study provides a comprehensive framework for assessing ICT adoption access points and offers policymakers' practical implications for empowering women by expanding ICT access to achieve Sustainable Development Goal 5.
Improved Predictability of Diagnosis and Prognosis Using Serum‐ and Tissue‐Derived Extracellular Vesicles From Bulk mRNA Sequencing in Pancreatic Ductal Adenocarcinoma
Authors: Zhu Qian , Chen Zhang , Tian Ming , Yan Xin , Gongye Xiangdong , Liu Zhicheng , Zhao Anbang , Yang Zhiyong , Yuan Yufeng 
Published: January 2025

ABSTRACTBackgroundEarly‐stage pancreatic ductal adenocarcinoma (PDAC) is frequently misdiagnosed, contributing to its high mortality rate. Exosomal microRNAs (miRNAs) have emerged as potential biomarkers for the early detection of PDAC.AimsThis study aimed to evaluate the feasibility of using exosomal miRNAs from PDAC tissues and serum as biomarkers for early detection and prognosis.Materials & MethodsExosomes were isolated from healthy individuals and PDAC patients via tissue and serum samples, then identified by analyzing their particle size and protein content. PDAC‐specific exosomal miRNAs were identified using a microRNA array. A large cohort was subsequently recruited to validate these findings. The diagnostic capacity of the identified miRNAs was assessed using the Brier score and area under the curve (AUC). Verified miRNAs were also used to confirm intracellular mRNA change patterns.ResultsThe combination of miR142‐3p, miR148a‐3p, and CA199 showed a higher AUC (0.747) compared to CA199 alone (0.716) in ROC curve analysis. Gene Ontology (GO) annotations revealed that the two‐miRNA panel was associated with multiple oncogenic pathways.Discussion142‐3p and miR148a‐3p were identified as specific to PDAC and, when combined with CA199, improved diagnostic accuracy. Their involvement in oncogenic pathways underscores their relevance as diagnostic and prognostic biomarkers.ConclusionMiR142‐3p and miR148a‐3p, alongside CA199, show promise as non‐invasive biomarkers for early detection and prognosis of PDAC, improving diagnostic accuracy.
Deep Learning and Multidisciplinary Imaging in Pediatric Surgical Oncology: A Scoping Review
Authors: Buser M. A. D. , van der Rest J. K. , Wijnen M. H. W. A. , de Krijger R. R. , van der Steeg A. F. W. , van den Heuvel‐Eibrink M. M. , Reismann M. , Veldhoen S. , Pio L. , Markel M. 
Published: January 2025

ABSTRACTBackgroundMedical images play an important role in diagnosis and treatment of pediatric solid tumors. The field of radiology, pathology, and other image‐based diagnostics are getting increasingly important and advanced. This indicates a need for advanced image processing technology such as Deep Learning (DL).AimOur review focused on the use of DL in multidisciplinary imaging in pediatric surgical oncology.MethodsA search was conducted within three databases (Pubmed, Embase, and Scopus), and 2056 articles were identified. Three separate screenings were performed for each identified subfield.ResultsIn total, we identified 36 articles, divided between radiology (n = 22), pathology (n = 9), and other image‐based diagnostics (n = 5). Four types of tasks were identified in our review: classification, prediction, segmentation, and synthesis. General statements about the studies'’ performance could not be made due to the inhomogeneity of the included studies. To implement DL in pediatric clinical practice, both technical validation and clinical validation are of uttermost importance.ConclusionIn conclusion, our review provided an overview of all DL research in the field of pediatric surgical oncology. The more advanced status of DL in adults should be used as guide to move the field of DL in pediatric oncology further, to keep improving the outcomes of children with cancer.
Functional Proteins/Peptides Targeting to Clear Amyloid‐β for Alzheimer's Disease Therapy
Authors: Gao Ziran , Hou Renjie , Qian Chenggen 
Published: January 2025

AbstractAlzheimer's disease (AD) is a significant neurodegenerative disorder primarily affecting individuals over the age of 65. It is characterized by impairments in memory, thinking, analytical judgment, visuospatial recognition, and mood. In recent years, the development of protein and peptide drugs targeting amyloid‐beta (Aβ) has gained momentum, with several therapies entering clinical trials and even receiving marketing approval. Novel functional protein and peptide drugs, as the first‐generation immunotherapeutic agents for neurodegenerative diseases, have pioneered cellular immunotherapy for AD. However, the currently available drugs are associated with toxicity issues, which can lead to serious complications such as cerebral hemorrhage or edema. Consequently, this study examines the potential for a new generation of Aβ‐targeting drugs to mitigate the side effects of existing treatments and offers innovative perspectives for the advancement of therapies for AD.
Genetically Encoded Nucleic Acid Nanostructures for Biological Applications
Authors: Yang Changping , Fan Jing , Zhu Hanyin , Wang Hong , He Yuling , Liu Jianbing , Ding Baoquan 
Published: January 2025

AbstractNucleic acid, as a carrier of genetic information, has been widely employed as a building block for the construction of versatile nanostructures with pre‐designed sizes and shapes through complementary base pairing. With excellent programmability, addressability, and biocompatibility, nucleic acid nanostructures are extensively applied in biomedical researches, such as bio‐imaging, bio‐sensing, and drug delivery. Notably, the original gene‐encoding capability of the nucleic acids themselves has been utilized in these structurally well‐defined nanostructures. In this review, we will summarize the recent progress in the design of double‐stranded DNA and mRNA‐encoded nanostructures for various biological applications, such as gene regulation, gene expression, and mRNA transcription. Furthermore, the challenges and future opportunities of genetically encoded nucleic acid nanostructures in biomedical applications will be discussed.
The Effect of Social CSR on Labor Investment Decisions: Theory and International Evidence
Authors: Palmeira Rafael , Pindado Julio 
Published: January 2025

ABSTRACTThis study analyzes how the social aspects of corporate social responsibility (CSR) influence firms' labor investment decisions. We provide new evidence using an international sample of 612 companies in 30 countries from 2012 to 2019; we use the generalized method of moments for our estimations. Our empirical analysis shows that increasing social CSR leads to labor overinvestment but reduces labor underinvestment. Our results also demonstrate that employment protection legislation limits the effects of social CSR on labor underinvestment. In conclusion, this study disentangles the relationship between social CSR and labor investment decisions. Finally, we discuss some relevant practical implications for managers and shareholders as we reveal the effect of social CSR on labor investment decisions and suggest a substitution effect between social CSR efforts and employment protection legislation.
Modification Strategies of Bismuth‐Based Halide Perovskites for Solar to Fuel Conversion by Photocatalytic CO2 Reduction
Authors: Tian Pei , Ding Yan , Zhang Fei , Zhang Yihao , Wei Jinjia , Chen Jie 
Published: January 2025

AbstractIn light of the increasingly pressing energy and environmental challenges, the use of photocatalysis to convert solar energy into chemical energy has emerged as a promising solution. Halide perovskites have recently attracted considerable interest as photocatalysts due to their outstanding properties. Early developments focused on Lead‐based perovskites, but their use has been severely restricted due to the toxicity of Lead. Consequently, researchers have introduced non‐toxic elements to replace Lead, with common substitutes being transition metals such as Tin (Sn), Bismuth (Bi), and Antimony (Sb). Among them, Bi‐based perovskites have demonstrated superior photocatalytic performance. Nevertheless, the inherent instability of perovskites and the severe recombination of charge carriers have necessitated the development of various modification strategies to enhance their performance. This Review discusses the modification strategies for Bi‐based halide perovskites and illustrates the impact of these strategies on the photocatalytic performance. Finally, future research directions and challenges of Bi‐based perovskites for photocatalysis are proposed.
Chemical and Enzymatic Mechanosynthesis of Organocatalytic Peptide Materials Based on Proline and Phenylalanine
Authors: Rios‐Echeverri Alexandra , Puerto Galvis Carlos E. , Ardila‐Fierro Karen J. , Hernández José G. 
Published: January 2025

AbstractIn recent years, mechanosynthesis of peptides through either chemical or enzymatic routes has been accomplished. In part, this advancement has been driven due to the organocatalytic properties of peptide‐based biomaterials. In this work, we report the merging of chemical and enzymatic protocols under mechanochemical conditions to synthesize peptide materials based on L‐proline and L‐phenylalanine. Compared to traditional step‐by‐step peptide synthesis in solution, our mechanochemical approach combining peptide coupling reagents with the proteolytic enzyme papain offers a more sustainable route by reducing the number of synthetic steps, shortening reaction times, increasing chemical yields, and minimizing waste production. Notably, the mechanosynthesized peptides exhibited organocatalytic activity in the asymmetric aldol reaction between cyclohexanone and 4‐nitrobenzaldehyde.