bluuebunny/crossref_metadata_2025_split huggingface dataset:
(27) FEELING HOT: EVALUATING NOCTURNAL ERECTION DETECTION WITH PENILE TEMPERATURE MEASUREMENTS IN THE SEARCH OF A MODERN ERECTILE DYSFUNCTION DIAGNOSTIC TOOL
Authors: Hille Torenvlied , Evelien Trip , Dr. Wouter Olthuis , Dr. Jack Beck 
Published: July 2023

Abstract

Objectives
In the search of a modernized tool for erectile dysfunction nature differentiation, implementation of overnight penile temperature measurements as a patient-friendly alternative for RigiScan® diagnostics, has gained interest. Until now, no study has investigated the effect of overnight environmental circumstances on the penile temperature during erection. The Feeling Hot study aims to determine the feasibility of (mimicked) nocturnal erection detection with penile temperature sensing.

Methods
Ten healthy young men obtained two visually aroused erections with commercially available pornography. Measurements of the penile temperature during erection in naked and blankets & underwear circumstance were performed with a thermistor sensor. Additionally, overnight penile temperature and simultaneous recorded RigiScan® measurements were conducted in the same test subjects. Data was analyzed to study the absolute penile temperature change during (mimicked) nocturnal erections as well as the visible detectability.

Results
Significant increase in penile temperature was found in the naked and mimicked overnight circumstance measurements at a mean temperature increase of respectively 1.70 0C and 0.67 0C. The first nocturnal erections, which showed a significant average temperature increase of 1.47 0C, were visibly detectable in all subjects. The penile temperature remained at peak levels for over 30-minutes after visually aroused erection. This lasting elevated temperature was also seen during overnight measurements and resulted in challenging detection of subsequent nocturnal erections.

Conclusions
The Feeling Hot study has shown that nocturnal erection detection with penile temperature measurements is feasible. Especially the first nocturnal erection can be validly detected. The detection of subsequent erections, which is challenged due to the low conductivity of overnight environmental circumstances, could be assisted by reference temperature measurements, slope analysis, artificial intelligence techniques or penile saturation measurements. Further research should focus on result validation and studying implementation for erectile dysfunction patients.

Conflicts of Interest
The Feeling Hot studies are part of a PhD studies investigating the feasibility of nocturnal erection detection with penile temperature measurements as an alternative for RigiScan diagnostics. There are no conflicts of interest and the used sensing system was created solely to perform the clinical studies of the research.
(54) MANAGING SMALL PENIS SYNDROME USING FILLER INJECTION FOR PENILE AUGMENTATION
Authors: Prof. Mykola I Boiko , Notsek S Mykola 
Published: July 2023

Abstract

Objectives
Research is conducted to evaluate the effectiveness of filler injection techniques for penile augmentation in managing small penis syndrome (SPS) or small penis anxiety.

Methods
We included 57 patients with SPS elected using Cosmetic Procedure Screening Scale for Penile Dysmorphic Disorder (COPS-P) in the study. Each patient underwent the procedure of penile augmentation with the injection of hyaluronic acid filler in the shaft (10 ml) and glans (4 ml) of the penis. The effectiveness was evaluated with Self-Esteem And Relationship (SEAR) questionnaire before and 3 months after the procedure.

Results
Regarding the SEAR questionnaire, the satisfaction of sexual life and self-esteem improved significantly compared with the results before surgery by 8.6 ± 0.46 (P &lt;0.001) points. The most serious complications after the procedure we observed in 2 patients: nodal formations and irregular filler distribution. These complications were resolved with hyaluronidase injections. It was reflected in the SEAR scores of those patients and had some effect on overall statistical results.

Conclusions
The injection method of penile augmentation significantly improves psychosexual status of the patients. It could be considered for the management of small penis syndrome after more detailed research as a safe and effective alternative to conservative approaches to therapy.

Conflicts of Interest
None
(161) COMPLICATIONS IN A SMALL VOLUME PENILE PROSTHESIS IMPLANT CENTRE.
Authors: Dr. Antonio Tienza , C Vega , M Guldris , R J Escribano , M A Podadera , A Pieras , Dr. Xavier Brugarolas 
Published: July 2023

Abstract

Objectives
To assess the complications that have occurred in a small volume centre.

Methods
The andrology unit started to perform penile prosthesis implant after a programmed organization five years ago, two urologist/andrologist were working together. Prospective data of consecutive patients were included from 2017 to 2021.
The following characteristics were collected: date of birth, chronic diseases, year of beginning of (erectile dysfuction) ED and the cause, treatments received, toxic habits, American Society of Anesthesiologist score, height and weight, date of the surgery, type of implant. Complications were collected as local: haematoma, infection; difficulties to learn to use it, limited use of the device.
Descriptive analysis: mean and range and percentage.

Results
20 male patients were collected. Mean age was 62 years (49-79). By cause of ED: 5 radical pelvic surgery, 3 multifactorial, 2 vascular, 1 diabetes, 1 peyronie disease, 6 unknown, 1 medullary lesion. Seven patients have concomitant peyronie disease. By chronic disease: 14 have hypertension, 8 diabetes, 7 obese, 10 overweight. 12 were activo or ex smokers.
2 were replacements and 18 first-implant surgeries. By type of implant we performed: 3 semirrigid, 7 2-piece and 10 3-piece.
Complications: 1 patients died due to previous oncological disease, 1 required to extract the device, 4 peno-escrotal haematoma without requiring drain, 3 reported difficulties to learn how to use it and 9 lack of use. The pandemic period, limited operating room available and reduced budget are the main enemies to increase the volume of implants.

Conclusions
Few complications were reported in our small volume center. A step period of surgeries and small group of surgeons are the key of the results.

Conflicts of Interest
None.
(133) BETTER PREOPERATIVE SEXUAL FUNCTION IS CORRELATED WITH FEWER DEPRESSIVE SYMPTOMS POSTOPERATIVELY: A RETROSPECTIVE STUDY OF PATIENTS OF A SEXUAL REHABILITATION AFTER RADICAL PROSTATECTOMY CLINIC
Authors: Stavros Kontogiannis , Anastasios Natsos , Mohammed Obaidat , Spyridon Tsounakos , Evangelia Goulimi , Konstantinos Asimakopoulos , Evangelos Liatsikos , Petros Drettas 
Published: July 2023

Abstract

Objectives
Prostate cancer has not only oncological and sexual effects, but psychological effects as well. The objective of this study was to evaluate the postoperative psychological state of patients after radical prostatectomy and to investigate the potential correlation with erectile function and prostate cancer aggressiveness.

Methods
We studied patients who visited the Sexual Rehabilitation after Radical Prostatectomy Clinic in the last 18 months. In our Clinic, we apply the biopsychosocial model in the evaluation of sexual dysfunctions. Because of this approach, patients were asked to fill in the Hospital Anxiety and Depressions Scale (HADS) questionary. HADS is an instrument used to evaluate anxiety (HADS-A) and depression (HADS-D) separately. Scores above 8 raise suspicion for underlying mental conditions. International Index of Erectile Function-5 (IIEF-5) was utilized to evaluate the erectile function. IIEF-5 was completed one day before surgery, while, both IIEF-5 and HADS were completed two months postoperatively. Postoperative Gleason score (GS)&gt;8 and pT3 according to pTNM staging were used as indicators of aggressive disease.

Results
In a total of 70 patients, the mean age was 65.7 years and the mean PSA of 9.4 ng/dl. Of those, 62.8% had pT3 staging and 28.5% had a GS of 8-10. Mean HADS-A & HADS-D scores were 7.4 and 5.8 respectively. Mean IIEF-5 score was 20.2 preoperatively and 6.5 postoperatively. The frequency of patients scoring above 8 for HADS-A and HADS-D was 40.2% and 28.5% respectively. A correlation between postoperative HADS-D and preoperative IEEF-5 was found. More specifically, higher preoperative IIEF-5 scores were associated with lower HADS-D scores (p=0.016). No correlation was found between both questionnaires and pT3 or GS of 8-10.

Conclusions
Patients with good preoperative erectile function have fewer depressive symptoms after radical prostatectomy. Mental state and erectile function are not correlated with prostate cancer agressiveness.

Conflicts of Interest
There is no conflict of interest for any of the authors.
(16) PEYRONIE’S DISEASE: MALE AND FEMALE PERSONAL EXPERIENCE
Authors: Vanessa Andrade , Thiago Guimarães , Mariana Medeiros , João Guerra , Miguel Gil , João Cunha , Pedro Silva , Fernando Calais , Luís C Pinheiro 
Published: July 2023

Abstract

Objectives
Evaluate the sexual impact of Peyronie’s disease in male and their female partners.

Methods
Retrospective analysis of all men submitted to a surgical repair of Peyronie’s disease from 2011 to 2021. The patients answered the “Peyronie’s Disease Questionnaire” and their female partners the “Peyronie’s Disease Questionnaire for Female Sexual Partners”.

Results
During this period, 25 patient had surgery to correct penile curvature due to Peyronie’s disease. 20 male patients and 16 female answered the questionnaires. Mean age was 61 years old. The majority of the patients had dorsal 30° curvature. Male and female partners reported a similar difficulty during vaginal intercourse (70% vs 68.4%, p=0,915) and similar discomfort during intercourse (85% vs 72.2%, p=0,438). Male were more frequently “very bothered” or “extremely bothered” about penis appearance than female partners (55% vs 20%, p=0,036), but female were more concern about damaging their partner’s penis than male (66,7% vs 5%, p&lt;0,001). Only 40% of men who answered the questionnaire were satisfied about penis appearance after surgery, with major problem being the shortening of penis.

Conclusions
Peyronie’s disease have similar impact during sexual intercourse for both male and female. Male have more concern about appearance and female about the possibility of damaging the partner’s penis. Most of the patients were not satisfied with the results of the surgery, mainly because of shortening of penis, a well-known complication of the surgery. It is really important to manage this condition with the couple and managing expectations about the results after correction.

Conflicts of Interest
None
(42) TREATMENT OF ACUTE PHASE OF PEYRONIE’S DISEASE WITH TAMOXIFEN AND VARDENAFIL/TADALAFIL OFF LABEL
Authors: Jeannette Verkerk-Geelhoed , Prof. Igle Jan D Jong , Dr. Jack Beck 
Published: July 2023

Abstract

Objectives
Peyronie’s Disease (PD) is a collagen disorder causing fibrotic tissue and curvature of the erect penis, with painful erections in the acute phase and difficulty with sexual intercourse. In two studies, rodent model and in vitro, Tamoxifen/Vardenafil together showed to be effective in the acute phase. In literature, spontaneous resolution of curvature is reported in 3-13%.
Aim: To investigate the effect of Tamoxifen and Tadalafil (T&T) off label on PD patients in the acute phase of PD.

Methods
Patients were included at the outpatient clinic for off label T&T treatment and vacuum erection device (VED) after extensive informed consent. Tadalafil 5mg prescribed once daily, Tamoxifen 10mg and VED twice daily. Descriptive statistics used for Baseline and outcome characteristics. Subgroup analysis by Fisher Exact and Chi-Square test for unpaired groups based on nominal or ordinal data.

Results
48 men included with mean age 53.0 (SD 9.5) and penile curvature at baseline 46.7° (SD 18.8). Median duration was four months, 70.8% (n=48) painful erections. Dorsal curvature in 27 (56.3%), mean stretched penile length 13.4 cm. Mean use of T&T was 13 weeks (1-52 weeks). Curvature improvement in 27.7%, pain reduction in 48.5%, sexual intercourse/coitus improvement in 34.2%, erection improvement in 14.6%. Adverse reactions of T&T in 39.6% (n=19), 1% dose related, 6% stopped within 3 months. No serious side effects reported on VED.

Conclusions
Drug treatment is combined with the VED. Due to the Covid-19, pandemic several patients were consulted by phone or video consultation only. Therefore missing data on penile length and location of nodule, due to not being able to perform physical examination. Some patients got lost to follow up, therefore creating missing data in the reported outcomes. Conclusion: 27.7% reported improvement of curvature with T&T. This is a better outcome than spontaneous improvement as described in literature.

Conflicts of Interest
Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events J. Verkerk-Geelhoed form Ipsen and Besins Healthcare I.J. de Jong from Astra Zeneca J. Beck from MSD, Astellas, Sobi, Besins Healthcare, Health investment.
(55) “PENILE GRAFTING FOR PEYRONIE'S DISEASE WITH TACHOSIL: OUR EXPERIENCE”
Authors: Dr. Christos Fliatouras , Dr. Nikos Karypidis , Dr. Theodoros Spinos , Dr. Konstantinos Konstantinidis 
Published: July 2023

Abstract

Objectives
The purpose of this presentation is to report the results of penile grafting with the use of Tachosil for the restoration of Peyronie's disease.

Methods
The Egydio geometrical procedure was applied in patients with large penile curvature for whom penetration was extremely difficult. Interestingly, all patients had a preoperative penile curvature of 60 degrees or more. The decision for surgery was made following the guidelines of the European Association of Urology (EAU). The penile deformity has been stabilised preoperatively, while pain was absent in all patients for at least six months. All patients were potent or had mild erectile dysfunction preoperatively. All procedures were performed by the same high-volume surgeon who was highly experienced in the field of Andrology. All patients were older than 45 years, while many of them had comorbidities, such as coronary artery disease or diabetes mellitus. Most of them, had a dorsal curvature, while 1 patient had a left-sided curvature and another 1 had a simultaneous hourglass-type lesion.

Results
The penile curvature was successfully repaired in all patients, with concomitant preservation of penile length. Interestingly, the vast majority of patients had excellent erectile function postoperatively, as well as preoperatively, while in most patients with pre-existing erectile dysfunction this did not worsen postoperatively. Even the most complex cases were able to have sex postoperatively, using PDE5 inhibitors or penile self-injections and benefiting from the use of stem cells and/or shockwave therapy.

Conclusions
We thus concluded that penile grafting with tachosil, for Peyronie's disease repair with the Egydio geometrical procedure, perfectly improves the shape of the penis, maintaining its length, without significantly affecting erectile function postoperatively. The mild degree of erectile dysfunction which may arise from this procedure can be efficiently managed with applying various treatment methods.

Conflicts of Interest
The authors declare no conflicts of interest.
(162) PENILE TRAUMA ANALYSIS AND FOLLOW-UP OF A SERIES
Authors: Dr. Antonio Tienza , Dr. Cristian V Casu , Dr. Jorge Guimera , Dr. Luis Ladaria , Dr. Priscila Benito , Dr. Jose Luis Bauza , Prof. Enrique Pieras , Dr. Xavier Brugarolas 
Published: July 2023

Abstract

Objectives
To describe and review a series of penile trauma.

Methods
Patients with suspicions of penile fracture that received surgical treatment were included from 2015 to 2022. Characteristics were collected: date of birth, type of fracture and affected parts of the penis, evolution after surgery. Description of complications and outcomes.

Results
11 consecutive patients received surgical treatment due to suspicion of penile trauma. 3 patients had negative previous ultrasonography. 3 showed bleeding without rupture, 2 rupture of both corpora cavernosa and urethra, 6 only one corpora. After recovery time 9 patients reported altered erectile function. 1 urethral stenosis. 2 penile curvature. 1 skin necrosis that required surgery. The prefered repairing technique was single stitch of resorbable suture.

Conclusions
Penile trauma is an emergency disease that requires surgical treatment. Once the damage is done serious and permanent impairment may occur.

Conflicts of Interest
None.
(273) WHAT IS THE EFFICACY OF CBT INTERVENTIONS ON MENTAL AND SEXUAL HEALTH OF PROSTATE CANCER SURVIVORS? A SYSTEMATIC REVIEW
Authors: Sonia Pieramico , Rita Castro , Sandra Aguiar , Francisca Bismarck , Diana Ferreira , Ana L Quinta Gomes , Prof. Joana Carvalho , Prof. Pedro Nobre 
Published: July 2023

Abstract

Objectives
Prostate cancer (PCa) is the second most frequently diagnosed oncological condition among biological men, impacting physical and psychological well-being, as well as sexual health and quality of life. Cognitive behavioral interventions (CBT) have shown to be an effective approach for a wide range of psychological and sexual difficulties and have more recently been tested as an intervention to improve sexual and mental health of PCa survivors. The present systematic review aimed to methodically research and summarize results regarding CBT’s effectiveness regarding mental and sexual health variables of prostate cancer survivors.

Methods
A systematic search was carried out using electronic databases until August 2022. By means of a combination of search words (such as prostate cancer, psychological interventions, mental health, cognitive behavioral intervention, CBT, cognitive behavioral therapy, sexuality, sexual dysfunction, sexual health, depression, anxiety, quality of life, and randomized control trial) and by selecting articles according to inclusion and exclusion criteria, 15 randomized controlled trials were considered.

Results
Three studies showed evidence of intervention efficacy for the improvement of sexual health while other eight for mental health dimensions. More specifically, CBT interventions may be effective for PCa survivors to overcome cancer-related distress, and depressive symptoms while improving relaxation skills, emotional well-being, benefit finding, and their outlook on the future. Furthermore, such interventions may have the potential to improve sexual satisfaction, sexual function (such as erectile function), and sexuality-related self-esteem.

Conclusions
However, further research is needed to confirm these findings, and increase efficacy as well as assure generalizability. While there is evidence for the effectiveness of such interventions on mental and sexual health dimensions, further research with a larger and more diverse population is needed.
The present research is supported by the project “SexHealth & ProstateCancer” (NORTE-010145-FEDER-000057) financed by the Horizon Europe Funding Program.

Conflicts of Interest
We have no conflict of interest do disclose.
(247) VASECTOMY METHODS, THEIR RESULTS AND COMPLICATIONS
Authors: Marek Broul 
Published: July 2023

Abstract

Objectives
Vasectomy is a common method of male sterilization. However, it is less popular worldwide than tubal ligation in women. Vasectomy is also a potential cause of lawsuits related to its complications. This paper summarizes the early and late complications of this surgical procedure.

Methods
Data from the Medline database were used and the search terms used were "vasectomy complications", "vasectomy + infection", "vasectomy + endocarditis", "vasectomy + failure", vasectomy + cancer" and "vasectomy + death".

Results
According to the Guidelines of the European Urological Society, vasectomy is evaluated as a safe and effective method and is recommended as one of the methods of male contraception. The recommended vasectomy procedure is a scalpel-free approach to the fallopian tube, followed by dissection with fascia interposition or coagulation of the fallopian tube lumen. This method has fewer complications immediately after surgery and a higher long-term success rate than the method with a scalpel approach and without coagulation or fascial interposition. Furthermore, it is generally recommended to perform the procedure under local anaesthesia only, which again has fewer complications than general anaesthesia.

Conclusions
Vasectomy is a safe and relatively simple method of male contraception. It has a lower morbidity and mortality rate than tubal ligation in women. No relationship between vasectomy and the development of immunological, cardiovascular or cancer diseases has been confirmed. The possible complications are summarized in Table 1. Patients must always be informed before the procedure about the possible complications and the possibility of irreversibility of the procedure.

Conflicts of Interest
None.
(83) SERUM TESTOSTERONE MIRRORS INFLAMMATION PARAMETERS IN FEMALES HOSPITALIZED WITH COVID-19
Authors: Dr. Walter Vena , Dr. Maria F Birtolo , Dr. Alessandro Pizzocaro , Dr. Alessandro Brunetti , Dr. Simona Jaafar , Dr. Nazarena Betella , Dr. Antonio C Bossi , Prof. Gherardo Mazziotti , Prof. Andrea G Lania 
Published: July 2023

Abstract

Objectives
While low testosterone (T) was described as a predictor of unfavorable coronavirus-disease 19 (COVID-19) outcome in men, data concerning the role of T in women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are scant and limited to small cohorts. This study aimed to investigate the relationship between serum T values and outcomes of COVID-19 in a large female hospitalized cohort.

Methods
One-hundred-sixty-eight adult women (median age 77, range 18-100 years; 154 in post-menopause) hospitalized for COVID-19 were assessed for PaO2/Fio2 ratio, serum T and inflammatory parameters.

Results
Median duration for hospital stay was 14.2 days (range 1-115) with overall mortality of 26% (n=44). Subjects who died were significantly older (p&lt; 0.001), had significantly more comorbidities (p=0.015) and higher serum T (p=0.040), white blood cells (p=0.007), c-reactive protein (CRP; p&lt;0.001), interleukin-6 (IL-6; p&lt; 0.001), procalcitonin (PCT; p&lt;0.001), lactate dehydrogenase (LDH; p=0.001), D-dimer (p=0.035), fibrinogen (p=0.038) and lower serum free-triiodothyronine (FT3; p&lt;0.001) and luteinizing hormone (LH; p=0.024) values. In post-menopausal women, significant associations were observed between T levels and serum CRP (rho: 0.23; p=0.002), IL-6 (rho: 0.41; p&lt;0.001), LDH (rho: 0.34; p&lt;0.001), D-Dimer (rho: 0.21; p=0.008), PCT (rho: 0.26; p=0.001) and HDL cholesterol (rho: -0,22, p = 0.008). In multivariate regression analyses, serum T maintained the significant association with mortality after correction for age, coexistent comorbidities and serum LH and FT3, whereas it was lost after correction for inflammatory parameters.

Conclusions
In females, high serum T levels might be a mirror of inflammatory phenotype and worse COVID-19 course.

Conflicts of Interest
Walter Vena received a project grant from IBSA. All other authors declare they do not have conflict of interest that is relevant to the subject matter or materials included in this work.