bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Posterior Tibial Slope Increases Force on the Posterior Medial Meniscus Root
Authors: Melugin Heath P. , Brown Justin R. , Hollenbeck Justin F.M. , Fossum Bradley W. , Whalen Ryan J. , Ganokroj Phob , Provencher CAPT Matthew T. 
Published: September 2023

Background: Posterior medial meniscus root (PMMR) tears have been associated with increased posterior tibial slope, but this has not been fully evaluated biomechanically. In addition, the effects of knee flexion and rotation on the PMMR are not well understood biomechanically because of technological testing limitations. A novel multiaxial force sensor has made it possible to elucidate answers to these questions. Purpose: (1) To determine if increased posterior tibial slope results in increased posterior shear force and compression on the PMMR, (2) to evaluate how knee flexion angle affects PMMR forces, and (3) to assess how internal and external rotation affects force at the PMMR. Study Design: Controlled laboratory study. Methods: Ten fresh-frozen cadaveric knees were tested in all combinations of 3 posterior tibial slopes and 4 flexion angles. A multiaxial force sensor was connected to the PMMR and installed below the posterior tibial plateau maintaining anatomic position. The specimen underwent a 500-N compression load followed by a 5-N·m internal torque and a 5-N·m external torque. The magnitude and direction of the forces acting on the PMMR were measured. Results: Under joint compression, an increased tibial slope significantly reduced the tension on the PMMR between 5° and 10° (from 13.5 N to 6.4 N), after which it transitioned to a significant increase in PMMR compression, reaching 7.6 N at 15°. Under internal torque, increased tibial slope resulted in 4.7 N of posterior shear at 5° significantly changed to 2.0 N of anterior shear at 10° and then 8.2 N of anterior shear at 15°. Under external torque, increased tibial slope significantly decreased PMMR compression (5°: 8.9 N; 10°: 4.3 N; 15°: 1.1 N). Under joint compression, increased flexion angle significantly increased medial shear forces of the PMMR (0°, 3.8 N; 30°, 6.2 N; 60°, 7.3 N; 90°, 8.4 N). Under internal torque, 90° of flexion significantly increased PMMR tension from 2.3 N to 7.5 N. Under external torque, 30° of flexion significantly increased PMMR compression from 4.7 N to 12.2 N. Conclusion: An increased posterior tibial slope affects compression and anterior shear forces at the PMMR. An increased flexion angle affects compression, tension, and medial shear forces at the PMMR. Clinical Relevance: The increase in compression and posterior shear force when the knee is loaded in compression may place the PMMR under increased stress and risk potential failure after repair. This study provides clinicians with information to create safer protocols and improve repair techniques to minimize the forces experienced at the PMMR.
Vasopressin Initiation as a Second-Line VasoPressor in Early Septic Shock (VISPSS)
Authors: Ragoonanan David , Nickelsen Paige , Tran Nicolas , Allen Bryan , Emborski Rebecca , Legare Anit , Vilella Antonia , Hampson Lauryn , Busey Kirsten , Shomo Eileen , Broomfield Abby , Hailu Kirubel 
Published: September 2023

Background Vasopressin is recommended as a second-line vasoactive agent for the management of septic shock; however, a paucity of data to guide its optimal use remains. The aim was to evaluate the effect of time-to vasopressin initiation and norepinephrine (NE) dose at vasopressin initiation on clinical outcomes in patients presenting with septic shock. Methods This was a multi-centered, retrospective, observational study conducted in patients with septic shock. Patients were divided into 2 groups: patients initiated on vasopressin when NE-equivalent dose (NEE) < 0.25 mcg/kg/min or ≥ 0.25 mcg/kg/min. The primary outcome was time-to-vasopressor discontinuation (hours). Secondary outcomes included 28-day in-hospital mortality, intensive care unit (ICU) length of stay (LOS), fluid balance after 72 hours, and the change in NEE at 12 hours. Results A total of 302 patients were included in this study. After propensity-score matching, 73 patients in each group were identified for analysis. There was no significant difference in the time-to-vasopressor discontinuation (hours) between the groups (88.8 [55–187.5] vs 86.7 [47–172]); p = 0.7815). Fluid balance (mL) at 72 hours was significantly lower when vasopressin was initiated at NEE < 0.25 mcg/kg/min (1769 [71–7287] vs 5762 [1463–8813]; p = 0.0077). A multivariable linear regression showed shorter time to shock resolution with earlier vasopressin initiation, defined as within 4 hours (p < 0.05). Conclusion In this propensity-score matched cohort, vasopressin initiation at NEE < 0.25 mcg/kg/min was not associated with shorter vasopressor duration. There was a lower fluid balance at 72 hours when vasopressin was initiated at lower NE doses.
Effectiveness of videoconference-delivered psychotherapy for children, adolescents, and their parents: A meta-analysis of randomized controlled trials
Authors: von Wirth Elena , Willems Sarah , Döpfner Manfred , Kohl Lea Teresa 
Published: September 2023

Introduction Over the last years, videoconference-delivered psychotherapy (VCP) has found its way into clinical practice. This meta-analysis is the first to evaluate the effectiveness of VCP for children and adolescents with a mental disorder and their parents. Methods A systematic literature search was performed to identify randomized controlled trials (RCTs) that compared the effectiveness of VCP for youths with a mental disorder to a control condition. Twelve studies were included. Two reviewers independently extracted data and rated study quality. Results Effect size estimates for measures of children's symptoms of mental disorders were large for comparison between VCP and waitlist (posttreatment: Hedges's g = −1.26, k = 5) and negligible for comparisons between VCP and in-person treatment (posttreatment: g = 0.00, k = 6; follow-up: g = −0.05, k = 3). Similarly, effect size estimates for measures of children's functional impairments were large for comparison between VCP and waitlist (posttreatment: g = −1.10, k = 3) and negligible for comparisons between VCP and in-person treatment (posttreatment: g = −0.23, k = 3; follow-up: g = 0.04, k = 2). VCP more effectively reduced symptoms in children with an internalizing disorder ( g = −0.88, k = 5) compared to externalizing disorders ( g = 0.25, k = 2) or tic disorders ( g = −0.08, k = 3). Discussion The results provide preliminary evidence that VCP is an effective treatment for youths with a mental disorder and their parents. VCP was equally effective as in-person treatment in reducing children's symptoms and functional impairments. Limitations include the limited number of RCTs and incomplete reporting of methodological features.
Antiangiogenic Activity of Mangostins Isolated from Thailand Stingless Bee Propolis
Authors: Ohta Toshiro , Ishizu-Nagashima Eriko , Mizuno Sayaka , Miyata Ryo , Vongsak Boonyadist , Kumazawa Shigenori 
Published: September 2023

Background/Objective Propolis, a resinous substance collected by honeybees from origin plants to protect their beehive, has been reported to have various biological activities and gained popularity as an alternative medicine in recent years. We have previously reported the plant origin, the chemical composition and some biological activities of native Thailand stingless bee propolis. In this study, we further elucidated its active components and their mode of action. Methods/Results Among nine prenylated xanthones isolated from this propolis, α-mangostin and γ-mangostin were shown to strongly inhibit tube formation of human umbilical vein endothelial cells (HUVECs), an indication of antiangiogenic activity in vitro. Further investigation of their effects at a molecular level revealed that both mangostins inactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and activated p38 in tube-forming HUVECs in a concentration-dependent manner. Taken together, the two mangostins were shown to inhibit angiogenesis in vitro by inactivating angiogenic signal ERK1/2 and activating stress signal p38. Detailed comparison revealed that α-mangostin seemed to have a slightly stronger effect than γ-mangostin in these experiments. Combined with the fact that being the most abundant component among the nine prenylated xanthones tested, α-mangostin might be responsible for the antiangiogenic activity of this Thailand stingless bee propolis. Conclusion These results indicate that α-mangostin isolated from Thailand stingless bee propolis may be a good candidate for future applications in the prevention of angiogenesis-related diseases.
Mental Health Screening Differences in Non-English Speaking Patients: Results From a Retrospective Cohort Study
Authors: Müller Frank , Abdelnour Alyssa M. , Rutaremara Diana N. , Arnetz Judith E. , Achtyes Eric D. , Alshaarawy Omayma , Holman Harland T. 
Published: September 2023

Purpose: To assess differences in mental health screening based on patient’s preferred language. Methods: For this retrospective cohort study, data for 85 725 unique patients from 10 primary care clinics in West Michigan were analyzed if patients received at least 1 mental health screening with the Patient Health Questionnaire 4 (PHQ-4) within a 12-month period (10/15/2021-10/14/2022). A general linear regression model was used to assess the adjusted odds ratios (aOR) of being screened. Results: Patients having a preferred language other than English (n = 2755) had an 87.0% chance of receiving the recommended mental health screening, compared to 76.7% of English-speaking patients ( P < .001). A multivariable model revealed decreased screening odds for Kinyarwanda (aOR 0.29, 95% CI 0.19-0.45) and Persian/Dari/Pashto (aOR 0.46, 95% CI 0.23-0.91) speaking patients and higher screening odds for Spanish (aOR 1.45, 95% CI 1.19-1.77), Bosnian (aOR 2.13, 95% CI 1.11-4.11), and Vietnamese (aOR 2.25 95% CI 1.64-3.08) speaking patients compared to English speaking patients. Conclusions: Results highlight the inequities between the language groups that are probably the result of the challenges to access multilingual depression and anxiety screening instruments. Furthermore, providers may be prone to bias about who they think “needs” a mental health screening. We suggest that measures are implemented to ensure consistency in mental health screening regardless of a patients’ preferred language.
Efficacy and safety of modular versus monoblock stems in revision total hip arthroplasty: a systematic review and meta-analysis
Authors: Wang Daofeng , Li Hua , Zhang Wupeng , Li Huanyu , Xu Cheng , Liu Wanheng , Li Jiantao 
Published: September 2023

Abstract
Background
Both modular and monoblock tapered fluted titanium (TFT) stems are increasingly being used for revision total hip arthroplasty (rTHA). However, the differences between the two designs in clinical outcomes and complications are not yet clear. Here, we intend to compare the efficacy and safety of modular versus monoblock TFT stems in rTHA.

Methods
PubMed, Embase, Web of Science, and Cochrane Library databases were searched to include studies comparing modular and monoblock implants in rTHA. Data on the survivorship of stems, postoperative hip function, and complications were extracted following inclusion criteria. Inverse variance and Mantel–Haenszel methods in Review Manager (version 5.3 from Cochrane Collaboration) were used to evaluate differences between the two groups.

Results
Ten studies with a total of 2188 hips (1430 modular and 758 monoblock stems) were finally included. The main reason for the revision was aseptic loosening. Paprosky type III was the most common type in both groups. Both stems showed similar re-revision rates (modular vs monoblock: 10.3% vs 9.5%, P = 0.80) and Harris Hip Scores (WMD = 0.43, P = 0.46) for hip function. The intraoperative fracture rate was 11.6% and 5.0% (P = 0.0004) for modular and monoblock stems, respectively. The rate of subsidence > 10 mm was significantly higher in the monoblock group (4.5% vs 1.0%, P = 0.003). The application of extended trochanteric osteotomy was more popular in monoblock stems (22.7% vs 17.5%, P = 0.003). The incidence of postoperative complications such as periprosthetic femoral fracture and dislocation was similar between both stems.

Conclusions
No significant difference was found between modular and monoblock tapered stems as regards postoperative hip function, re-revision rates, and complications. Severe subsidence was more frequent in monoblock stems while modular ones were at higher risk of intraoperative fracture.
Level of evidence: Level III, systematic review of randomized control and non-randomized studies.
Trial Registration: We registered our study in the international prospective register of systematic reviews (PROSPERO) (CRD42020213642).
National spine surgery registries’ characteristics and aims: globally accepted standards have yet to be met. Results of a scoping review and a complementary survey
Authors: Pascucci Simona , Langella Francesco , Franzò Michela , Tesse Marco Giovanni , Ciminello Enrico , Biondi Alessia , Carrani Eugenio , Sampaolo Letizia , Zanoli Gustavo , Berjano Pedro , Torre Marina 
Published: September 2023

Abstract
Background
Surgery involving implantable devices is widely used to solve several health issues. National registries are essential tools for implantable device surveillance and vigilance. In 2017, the European Union encouraged Member States to establish “registries and databanks for specific types of devices” to evaluate device safety and performance and ensure their traceability. Spine-implantable devices significantly impact patient safety and public health; spine registries might help improve surgical outcomes. This study aimed to map existing national spine surgery registries and highlight their features and organisational standards to provide an essential reference for establishing other national registries.

Methods
A scoping search was performed using the Embase, PubMed/Medline, Scopus, and Web of Science databases for the terms “registry”, “register”, “implantable”, and all terms and synonyms related to spinal diseases and national registries in publications from January 2000 to December 2020. This search was later updated and finalised through a web search and an ad hoc survey to collect further detailed information.

Results
Sixty-two peer-reviewed articles were included, which were related to seven national spine registries, six of which were currently active. Three additional active national registries were found through the web search. The nine selected national registries were set up between 1998 and 2021. They collect data on the procedure and use patient-reported outcome measures (PROMs) for the follow-up.

Conclusion
Our study identified nine currently active national spine surgery registries. However, globally accepted standards for developing a national registry of spine surgery are yet to be established. Therefore, an international effort to increase result comparability across registries is highly advisable. We hope the recent initiative from the Orthopaedic Data Evaluation Panel (ODEP) to establish an international collaboration will meet these needs.
Potential for high toxicity of polystyrene nanoplastics to the European Daphnia longispina
Authors: de Souza Machado Anderson Abel , Ghadernezhad Nesar , Wolinska Justyna 
Published: September 2023

Abstract
Background
Current regulatory discussions about microplastics are often questioned based on a lack of data indicating high ecotoxic hazards of these particles within standard and recognized definitions. Moreover, there is scientific debate on what metrics to report the micro-nanoplastics toxicity (i.e. mass or particle counts-based exposure). We present here the high potential sensitivity of three genotypically different clones of the European Daphnia longispina species complex exposed to non-functionalized polystyrene nanobeads of 50 nm and 100 nm in diameter according to adapted OECD 202 test protocol.

Results
EC50s 48 h varied from 0.2 to 8.9 mg L−1 (mean 2.49 mg L−1) for 50 nm beads, and from 32.7 to 90.3 mg L−1 (mean 59.39 mg L−1) for the 100 nm. EC10s 48 h varied from 0.0007 to 7.5 mg L−1 (mean 0.28 mg L−1) for 50 nm beads, and from 25.5 to 69.1 mg L−1 (mean 47.51 mg L−1) for the 100 nm. Inter-clonal variability was about tenfold. Therefore, several 1000 s-fold variations in mass-based ecotoxicity for these polystyrene beads was observed if particle size and Daphnia genotype are considered jointly.

Conclusions
Such ecotoxicity potential is comparable to highly toxic chemicals in global and EU-based regulatory classification and labelling. Ecotoxicity based on particle counts suggested convergence of EC50s, with effects generally observed around 1011 to1015 particles L−1. The present results highlight the potential high hazard of these particles and the relevance of particle size and exposure metrics on hazard conclusion.

Graphical Abstract
Comparative transcriptomic analysis of wheat cultivars differing in their resistance to Fusarium head blight infection during grain-filling stages reveals unique defense mechanisms at play
Authors: Chen Can , Guo Qi , He Qifang , Tian Zhuangbo , Hao Weihao , Shan Xinyu , Lu Jie , Barkla Bronwyn J. , Ma Chuanxi , Si Hongqi 
Published: September 2023

AbstractFusarium head blight (FHB) is a devastating fungal disease that poses a significant threat to wheat production, causing substantial yield losses. Understanding the molecular mechanisms of wheat resistance to FHB is crucial for developing effective disease management strategies. This study aimed to investigate the mechanisms of FHB resistance and the patterns of toxin accumulation in three wheat cultivars, Annong8455, Annong1589, and Sumai3, with different levels of resistance, ranging from low to high respectively, under natural field conditions. Samples were taken at three different grain-filling stages (5, 10, and 15 DPA) for gene expression analysis and phenotypic observation. Results found that toxin concentration was inversely correlated with varietal resistance but not correlated with disease phenotypes, indicating that toxin analysis is a more accurate measure of disease status in wheat ears and grains. Transcriptomic data showed that Sumai3 exhibited a stronger immune response during all stages of grain filling by upregulating genes involved in the active destruction of pathogens and removal of toxins. In contrast, Annong1589 showed a passive prevention of the spread of toxins into cells by the upregulation of genes involved in tyramine biosynthesis at the early stage (5 DPA), which may be involved in cell wall strengthening. Our study demonstrates the complexity of FHB resistance in wheat, with cultivars exhibiting unique and overlapping defense mechanisms, and highlights the importance of considering the temporal and spatial dynamics of gene expression in breeding programs for developing more resistant wheat cultivars.
Clinical characteristics and prognostic nomograms of 12555 non-severe COVID-19 cases with Omicron infection in Shanghai
Authors: Yin Chun , Hu Bo , Li Kunyan , Liu Xian , Wang Shuili , He Rulin , Ding Haibing , Jin Mingpeng , Chen Cheng 
Published: September 2023

Abstract
Background
Omicron variant of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global threat to public health. Numerous asymptomatic and mild cases had been admitted in shelter hospitals to quickly win the fight against Omicron pandemic in Shanghai. However, little is known about influencing factors for deterioration and length of stay (LOS) in hospitals among these non-severe cases.

Methods
This study included 12,555 non-severe cases with COVID-19 in largest shelter hospital of Shanghai, aiming to explore prognostic factors and build effective models for prediction of LOS.

Results
Data showed that 75.0% of participants were initially asymptomatic. In addition, 94.6% were discharged within 10 days, only 0.3% with deterioration in hospitals. The multivariate analysis indicated that less comorbidities (OR = 1.792, P = 0.012) and booster vaccination (OR = 0.255, P = 0.015) was associated with the decreased risk of deterioration. Moreover, age (HR = 0.991, P < 0.001), number of symptoms (HR = 0.969, P = 0.005), time from diagnosis to admission (HR = 1.013, P = 0.001) and Cycle threshold (CT) values of N gene (HR = 1.081, P < 0.001) were significant factors associated with LOS. Based on these factors, a concise nomogram model for predicting patients discharged within 3 days or more than 10 days was built in the development cohort. In validation cohort, 0.75 and 0.73 of Areas under the curve (AUC) in nomograms, similar with AUC in models of simple machine learning, showed good performance in estimating LOS.

Conclusion
Collectively, this study not only provides important evidence to deeply understand clinical characteristics and risk factors of short-term prognosis in Shanghai Omicron outbreaks, but also offers a concise and effective nomogram model to predict LOS. Our findings will play critical roles in screening high-risk groups, providing advice on duration of quarantine and helping decision-makers with better preparation in outbreak of COVID-19.
Prevalence of allergen sensitization among children with allergic rhinitis in Changzhou, China: a retrospective observational study
Authors: Hu Zhibang , Xue Jianrong , Pan Min , Bao Yongzheng , Zou Wenlan , Wang Chunhui , Ma Jing 
Published: September 2023

Abstract
Objective
To determine the prevalence of sensitivity to common inhaled and food allergens among children with allergic rhinitis (AR) in Changzhou in eastern China and provide a basis for epidemiological research of pediatric allergic rhinitis and allergen avoidance in this region.

Methods
This was a retrospective observational study, a total of 1248 children with AR were enrolled at the Third People’s Hospital of Changzhou between January 2018 and December 2019. The serum-specific immunoglobulin E (sIgE) to 19 kinds of inhaled and food allergens and serum total IgE were detected with the AllergyScreen test (Mediwiss Analytic GmbH, Moers, Germany). All participants had a positive reaction to at least one allergen in the test (the sIgE concentration ≥ 0.35 IU/ml).

Results
Among the patients, 818 (65.54%) were male and 430 (34.46%) were female, with 81 (6.50%) aged 1–3 year, 501 (40.14%) aged 4–7 year, and 666 (53.36%) aged 8–14 year. The positivity rate of inhaled allergens was 80.05% (n = 999), while the positivity rate of food allergens was 66.19% (n = 826). 828 patients (66.35%) were sensitized to multiple allergens. The most common inhaled allergens were Dermatophagoides pteronyssinus (65.38%), mold mix (25.56%), house dust (20.67%), and dog hair dander (13.94%), and the most common food allergens were cow’s milk (30.31%), cashew nut (27.9%), egg (22.68%), and beef (12.98%). With an increase in age, the inhaled allergen positivity rate showed a significant increase (P < 0.01), while the food allergen positivity rate decreased significantly (P < 0.01). There were significant age differences in total IgE levels (P < 0.01) and the total IgE level was highest in the group aged 8–14 year.

Conclusions
Dermatophagoides pteronyssinus was the most common sensitizing allergen in pediatric patients with AR in Changzhou. Several other inhaled and food allergens were also common. We observed that multiple allergenic factors play an important role in the occurrence and development of AR.