bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjunctive virtual reality pain relief after traumatic injury: a proof-of-concept within-person randomized trial
Authors: Morris Nicholas A. , Wang Yang , Felix Ryan B. , Rao Aniruddha , Arnold Shannon , Khalid Mazhar , Armahizer Michael J. , Murthi Sarah B. , Colloca Luana 
Published: April 2023

Abstract
In this study, we hypothesized that immersive virtual reality (VR) environments may reduce pain in patients with acute traumatic injuries, including traumatic brain injuries. We performed a randomized within-subject study in patients hospitalized with acute traumatic injuries, including traumatic brain injury with moderate pain (numeric pain score ≥3 of 10). We compared 3 conditions: (1) an immersive VR environment (VR Blu), (2) a content control with the identical environment delivered through nonimmersive tablet computer (Tablet Blu), and (3) a second control composed of donning VR headgear without content to control for placebo effects and sensory deprivation (VR Blank). We enrolled 60 patients, and 48 patients completed all 3 conditions. Objective and subjective data were analyzed using linear mixed-effects models. Controlling for demographics, baseline pain, and injury severity, we found differences by conditions in relieving pain (F2,75.43 = 3.32, P = 0.042). VR Blu pain reduction was greater than Tablet Blu (−0.92 vs −0.16, P = 0.043), but VR Blu pain reduction was similar to VR Blank (−0.92 vs −1.24, P = 0.241). VR Blu was perceived as most effective by patients for pain reduction (F2,66.84 = 16.28, P < 0.001), and changes in measures of parasympathetic activity including heart rate variability (F2,55.511 = 7.87, P < 0.001) and pupillary maximum constriction velocity (F2,61.41 = 3.50, 1-tailed P = 0.038) echoed these effects. There were no effects on opioid usage. These findings outlined a potential clinical benefit for mollifying pain related to traumatic injuries.
Sex and time-of-day differences in kidney oxygen consumption
Authors: Dutta Pritha , Layton Anita T. 
Published: April 2023

AbstractRenal hemodynamics, renal transporter expression levels, and urine excretion all exhibit circadian variations. Disturbance of these diurnal patterns is associated with hypertension and chronic kidney disease. Renal hemodynamics determines oxygen delivery, whereas renal transport and metabolism determines oxygen consumption. The balance between oxygen delivery and consumption then yields renal oxygenation. We hypothesized that kidney oxygenation also demonstrates 24-h periodicity. Another notable modulator of kidney function is sex, which has impacts on renal hemodynamics and transport function that are regulated by as well as independent of the circadian clock. The goal of this study was to investigate the diurnal and sexual variations in renal oxygen consumption and oxygenation. For this purpose, we developed computational models of rat kidney function that represent sexual dimorphism and circadian variation in renal hemodynamics and transporter activities. Model simulations predicted substantial differences in tubular Na+transport and oxygen consumption among different nephron segments. We also simulated the effect of loop diuretics, which are used in the treatment of renal hypoxia, on the outer medullary oxygen tension. Our model predicted a significantly higher effect of loop diuretics on renal oxygenation in female rats compared to male rats. In addition, loop diuretics were more effective when administered during the active phase.
Pharmacological characterization of FC-12738: A Novel Retro-Inverso Pentapeptide for Treating Neuroinflammation
Authors: Ellison Siobhan 
Published: April 2023

AbstractFC-12738, a retro-inverso pentapeptide developed by Neurodegenerative Disease Research, Inc., is currently under investigation for treating neuroinflammation associated with amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the pharmacokinetic properties of FC-12738, including absorption, distribution, metabolism, excretion, and drug-drug interactions. Pharmacokinetics were assessed in Sprague-Dawley rats and beagle dogs following intravenous and subcutaneous administration. Our findings suggest that FC-12738 demonstrates many favorable pharmacokinetic properties, although further optimization may be required to improve CNS penetrance.
OVERVIEW OF ETHICS COMMITTEE REGISTRATION AND RE-REGISTRATION WITH THE DEPARTMENT OF HEALTH RESEARCH IN INDIA
Authors: Kamath Yash , Shetty Yashashri , Kulkarni Ankita 
Published: April 2023

AbstractThe Government of India requires all ethics committees (EC) to register themselves with the Department of Health Research (DHR) and the study aimed to analyze the same. Since post-graduation mandates research – necessitating the presence of EC in the institution – we aimed to analyze the status of registrations along with the presence of ECs in National Medical Council(NMC) and Dental Council of India(DCI)-permitted colleges and also to study zone-wise differences in the same. We also studied the impact of COVID-19 on the registration process. The status of ECs was obtained from the DHR website. ECs information was extracted [location, date & type of Approval]. The search terms “College” and “Hospital” were used to locate Institutional ECs (IEC). A list of Medical and Dental colleges was obtained from the NMC and DCI Websites with their location information. Of 931 IECs, 103(11.06%) had final, 728(78.2%) had provisional approval while 100(10.74%) ECs registration had expired. The median delay to file for provisional approval was 857 (IQR=407) days. The expired ECs functioning without registration for 90 (IQR=131) days. 440 of 931 (47.3%) ECs got registered during the COVID-19 period. The IEC to Medical Colleges ratio shows a significant zone-wise difference (Kruskal-Wallis, p=0.019) with the Northern Zone having the highest mean ratio of 0.90(SD=0.63). It is vital to improve DHR compliance and the EC/College Ratio for appropriate ethical governance and improve international acceptance of Indian Research.
Machine learning detection of SARS-CoV-2 high-risk variants
Authors: Li Lun , Li Cuiping , Li Na , Zou Dong , Zhao Wenming , Xue Yongbiao , Zhang Zhang , Bao Yiming , Song Shuhui 
Published: April 2023

AbstractThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved many high-risk variants, resulting in repeated COVID-19 waves of pandemic during the past years. Therefore, accurate early-warning of high-risk variants is vital for epidemic prevention and control. Here we construct a machine learning model to predict high-risk variants of SARS-CoV-2 by LightGBM algorithm based on several important haplotype network features. As demonstrated on a series of different retrospective testing datasets, our model achieves accurate prediction of all variants of concern (VOC) and most variants of interest (AUC=0.96). Prediction based on the latest sequences shows that the newly emerging lineage BA.5 has the highest risk score and spreads rapidly to become a major epidemic lineage in multiple countries, suggesting that BA.5 bears great potential to be a VOC. In sum, our machine learning model is capable to early predict high-risk variants soon after their emergence, thus greatly improving public health preparedness against the evolving virus.
Atlas drug-eluting coronary stents inhibits neointimal hyperplasia in sheep modeling
Authors: Dinc Rasit , Yerebakan Halit 
Published: April 2023

AbstractBackgroundCoronary artery disease (CAD) is one of the leading causes of mortality and morbidity worldwide. Many patients with CAD require mechanical revascularization. However, restenosis after minimally invasive intervention is a major problem for these patients. Fortunately, due to the controlled drug delivery properties of drug-eluting stents (DES), this problem seems to be significantly overcome. In this study, the pharmacodynamic and pharmacokinetic properties of Atlas sirolimus-eluting coronary stents coated with PLGA were evaluated.Materials and MethodsThis study was carried out in 20 non-atherosclerotic female sheep, divided into four groups that included 4 study and 1 control randomly assigned to each group. The animals in the study groups were stented with Atlas Drug-eluting coronary stents and the pharmacodynamic and pharmacokinetic properties were evaluated.ResultsA statistically important effectivity of sirolimus on the vascular endothelium was shown. With time, the decrease in sirolimus in blood samples was statistically significant. In the others, no clinically significant side effects were observed.ConclusionsThe results in this study showed a significant reduction in neointimal hyperplasia after experimental implantation of Atlas drug-eluting stents coated with PLGA polymer. Pharmacokinetic studies also showed that the stent did not release significant left sirolimus after 28 days.
A rapid review of the effectiveness, efficiency, and acceptability of surgical hubs in supporting planned care activity
Authors: Okolie Chukwudi , Everitt Jordan , Wale Alesha , Morgan Helen , Ayres Toby , Shaw Hannah , Lewis Ruth , Cooper Alison , Edwards Adrian 
Published: April 2023

AbstractThe COVID-19 pandemic further exacerbated disruptions to elective care services in the UK, leading to longer waits for treatment and a growing elective surgery backlog. There have been growing calls for the creation of surgical hubs to help reduce this backlog. Surgical hubs aim to increase surgical capacity by providing quicker access to procedures, as well as facilitate infection control by segregating patients and staff from emergency care. This rapid review aimed to assess the effectiveness, efficiency, and acceptability of surgical hubs in supporting planned care activity, to inform the implementation of these hubs in Wales.The review identified evidence available up until January 2023. Twelve primary studies were included, eight of which used comparative methods. Most of the studies were conducted during the COVID-19 pandemic and described surgical hubs designed mainly to mitigate the transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Outcome measures reported included clinical, performance, economic, and patient reported outcomes across a variety of different surgical disciplines. Most of the studies did not describe surgical hubs based on their structure, i.e., standalone, integrated, or ring-fenced hubs.The evidence relating to the impact of surgical hubs on clinical outcomes appeared to be heterogenous and limited. Included studies did not appear to control for the impact of the COVID-19 pandemic on outcomes. Evidence of the impact of surgical hubs on performance outcomes such as efficiency, utilisation/usage, volume of surgeries/treatments, performance, cancellations, and time from diagnosis to treatment is limited. Evidence relating to the economic impact of surgical hubs is also limited, however there is evidence to suggest that total average costs are lower in surgical hubs when compared to general hospitals. Evidence relating to the impact of surgical hubs on patient reported outcomes is limited but indicates there may be a positive effect on patient satisfaction and compliance.Considerable variation in the types of surgical hubs reviewed, surgical disciplines, along with the small number of comparative studies, as well as methodological limitations across included studies, could limit the applicability of these findings.
Learning radar cross section of an intermeshing-rotor helicopter with blade pitch
Authors: Zhou Zeyang , Huang Jun 
Published: April 2023

Purpose
This study aims to study the radar cross-section (RCS) of an intermeshing rotor with blade pitch.

Design/methodology/approach
The variation of rotor blade pitch is designed into three modes: fixed mode, linear mode and smooth mode. The dynamic process of two crossed rotors is simulated, where the instantaneous RCS is calculated by physical optics and physical theory of diffraction.

Findings
Increasing the pitch angle in the fixed mode can reduce the average RCS of rotor at the given head azimuth. The RCS curve of helicopter in linear mode and smooth mode will have a large peak in the side direction at the given moment. Although the blade pitch in smooth mode is generally larger than that in fixed mode, the smooth mode is conducive to reducing the peak and mean value of helicopter RCS at the given heading azimuth.

Originality/value
The calculation method for analyzing RCS of intermeshing rotor with variable blade pitch is established.
The intricate web: network and rhizome metaphors in hypertext and the web and the epistemic challenge of fake news
Authors: Tredinnick Luke 
Published: April 2023

PurposeThis article analyses the structure of hypertext and the world wide web through the contrasting metaphors of the network and the rhizome and applies that analysis to the epistemic challenge presented by fake news.Design/methodology/approachThe paper is a critical and theoretical study of the development of concepts in information science. It outlines the limitations of the network metaphor and analyses the ways in which it has influenced both the development and critical understanding of the World Wide Web and its wider social and cultural consequences. The paper develops an alternative description of the ontological structure of the Web in terms of interrupted and dissipated energy flows.FindingsThe paper argues that the Web is better described as a dynamic reorganization of the socio-cultural system that has no determinate boundaries and which is constituted properly in the spaces between technologies and the spaces between persons.Originality/valueThe paper contributes to and extends research into the rhizomic nature of hypertext and the Word Wide Web and in understanding the role of metaphor in descriptions of hypertext and the web.
A model of collusion formation and measurement in the open ascending bid auctions in the agricultural markets
Authors: Das Dipankar 
Published: April 2023

PurposeThis paper gives a model of collusion formation and a method of measuring the degree of it among the traders/bidders in the agricultural commodity markets in India. The important assumption is that the bidding is repetitive with a set of common bidders. The theory has been derived based on the behavior of the wholesale market of agricultural commodities in India. The paper is based on full information in the collusion formation. The paper first derives the theoretical structure of the bidders' behavior and thereafter derives a measure of collusion formation with the help of real-life data.Design/methodology/approachThe paper used the standard theory of optimization and the theory of auction and probability statistics.FindingsThis is a complete information model of cartel formation. The bidding is repetitive and continues forever in discrete time. Hence bidders behavior is observable. Using the proposed method, if the APMC measures for each market and publishes on a periodic basis, say weekly basis, then it will be easier to break the collusion in the market where relative collision is present. For example, if a farmer has three options to sell in three different markets, then the published data would help them to select the market where the degree of collusion is relatively lower. Moreover, the undesirable loss can be avoided based on the right choice of market. As a result, transaction costs will be optima.Originality/valueThe paper first derives the theoretical structure of the bidders' behavior and thereafter derives a measure of collusion formation with the help of real-life data.
Innovative technology services: the human side of knowledge
Authors: Curto da Costa Daniele de Lourdes , Gomes Giancarlo , Borini Felipe Mendes , Alegre Joaquin 
Published: April 2023

PurposeAmong the existing literature, transformational leadership (TL), organizational culture (OC) and work–life balance (WLB) act as determinants of service innovation (SI). Specifically, the authors combine TL, OC and WLB into a model that clarifies these variables' influence on SI, particularly technological knowledge-intensive business services (T-KIBS).Design/methodology/approachA cross-sectional survey of 282 respondents from T-KIBS in Santa Catarina (Brazil) was conducted. The study used structural equation modeling (SEM) to test hypothesized relationships between the variables.FindingsThe results suggest a strong alignment of culture, leadership and WLB in T-KIBS. Therefore, it is shown that when the culture is strong and focused on SI, supporting the practices of employees, the transformative leaders can contribute with the same direction of actions supporting both WLB and SI. Likewise, the WLB is underpinned by cultures offering their employees support, well-being, creativity and innovation incentives.Originality/valueThe relationship between WLB and innovation is still emerging in research, not clearly defined in literature. Therefore, this study brings new and more in-depth information about these dimensions and their interrelations that influence SI. In addition, this conceptual framework has implications for practitioners not previously contemplated by the mainstream literature on KIBS.
A conceptual appraisal towards the contextualization of product and process innovation in clothing manufacturing
Authors: Ndwiga Duncan Kariuki , Ciera Lucy Wanjiru , Mokabi Geoffrey Ngugi 
Published: April 2023

Purpose
This study aims to address the aspects of product and process innovation strategies and their determining factors to understand their characteristics in clothing manufacturing and contribution for a successful and competitive clothing industry.

Design/methodology/approach
This general review is based on literature data of previous studies on innovation that transcend and cover the aspects of innovation applicable in the clothing industry. Although the scope of discussion is theoretically broad, it focusses on the context of innovation strategies in clothing manufacturing and the determinant factors indicating the acquisition and implementation of product and process-related innovation activities, simultaneously exploring and linking their implications for adopting, managing and integrating enterprise activities to the values of desired innovation novel models.

Findings
Based on theoretical background and pragmatic generalizations, product and process innovation strategies in clothing manufacturing firms tend to incline more towards computer-integrated technologies and concepts meant to promote product development, process optimization and organizational integration. Industry, technological and R&D factors tend to significantly determine innovation capability of a clothing firm.

Originality/value
This review generates integrated conceptual frameworks for product and process innovation strategies applicable in clothing firms and their determinant factors as prelude to empirical validation.
Influence of parents' education and home literacy environment on reading interest of deaf children
Authors: Wang Qianqian , Ma Minjie , Huang Yan , Wang Xichen , Wang Tingzhao 
Published: April 2023

BackgroundReading interest plays an important role in predicting and regulating the literacy development of deaf children, but the family factors influencing their reading interest have not been previously explored. The purpose of this study was to explore the effects of parents' education and home literacy environment (HLE) on reading interest of deaf children.MethodOne hundred and thirty‐two deaf children from Grades 1 to 6 aged 8–15 from China participated in our study. The parents of these children completed our survey of parents' education, HLE and children's reading interest. These variables were then processed and analysed by correlation, regression analyses and structural equation modelling.ResultsHLE played a complete intermediary role in the regression relationship between parents' education and reading interest of deaf children, and this effect had no significant difference between genders.ConclusionsParents' education has a positive and predictive effect on reading interest of deaf children, while creating a high‐quality HLE may improve this effect.
Social media and COVID‐19 vaccination hesitancy during pregnancy: a mixed methods analysis
Authors: Golder S. , McRobbie‐Johnson A. C. E. , Klein A. , Polite F. G. , Gonzalez Hernandez G. 
Published: April 2023

AbstractObjectiveTo evaluate the reasons for COVID‐19 vaccine hesitancy during pregnancy.DesignWe used regular expressions to identify publicly available social media posts from pregnant people expressing at least one reason for their decision not to accept COVID‐19 vaccine.SettingTwo social media platforms – WhatToExpect and Twitter.SampleA total of 945 pregnant people in WhatToExpect (1017 posts) and 345 pregnant people in Twitter (435 tweets).MethodsTwo annotators manually coded posts according to the Scientific Advisory Group for Emergencies (SAGE) working group's 3Cs vaccine hesitancy model (confidence, complacency and convenience barriers). Within each 3Cs we created subthemes that emerged from the data.Main Outcome MeasuresSubthemes were derived according to the people's posting own words.ResultsSafety concerns were most common and largely linked to the perceived speed at which the vaccine was created and the lack of data about its safety in pregnancy. This led to a preference to wait until after the baby was born or to take other precautions instead. Complacency surrounded a belief that they are young and healthy or already had COVID‐19. Misinformation led to false safety and efficacy allegations, or even conspiracy theories, and fed into creating confidence and complacency barriers. Convenience barriers (such as availability) were uncommon.ConclusionThe information in this study can be used to highlight the questions, fears and hesitations pregnant people have about the COVID‐19 vaccine. Highlighting these hesitations can help public health campaigns and improve communication between healthcare professionals and patients.
Progestogen maintenance therapy for prolongation of pregnancy after an episode of preterm labour: A systematic review and meta‐analysis
Authors: Breuking Sofie H. , De Ruigh Annemijn A. , Hermans Frederik J. R. , Schuit Ewoud , Combs C. Andrew , de Tejada Begoña Martinez , Oudijk Martijn A. , Mol Ben W. , Pajkrt Eva 
Published: April 2023

AbstractBackgroundEvidence for progestogen maintenance therapy after an episode of preterm labour (PTL) is contradictory.ObjectivesTo assess effectiveness of progestogen maintenance therapy after an episode of PTL.Search StrategyAn electronic search in Central Cochrane, Ovid Embase, Ovid Medline and clinical trial databases was performed.Selection CriteriaRandomised controlled trials (RCT) investigating women between 16+0and 37+0 weeks of gestation with an episode of PTL who were treated with progestogen maintenance therapy compared with a control group.Data Collection and AnalysisSystematic review and meta‐analysis were conducted. The primary outcome was latency time in days. Secondary neonatal and maternal outcomes are consistent with the core outcome set for preterm birth studies. Studies were extensively assessed for data trustworthiness (integrity) and risk of bias.Main ResultsThirteen RCT (1722 women) were included. Progestogen maintenance therapy demonstrated a longer latency time of 4.32 days compared with controls (mean difference [MD] 4.32, 95% CI 0.40–8.24) and neonates were born with a higher birthweight (MD 124.25 g, 95% CI 8.99–239.51). No differences were found for other perinatal outcomes. However, when analysing studies with low risk of bias only (five RCT, 591 women), a significantly longer latency time could not be shown (MD 2.44 days; 95% CI −4.55 to 9.42).ConclusionsProgestogen maintenance therapy after PTL might have a modest effect on prolongation of latency time. When analysing low risk of bias studies only, this effect was not demonstrated. Validation through further research, preferably by an individual patient data meta‐analysis is highly recommended.