bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomic response to early head‐up tilt in patients with severe traumatic brain injury: Analysis from a randomized feasibility trial
Authors: Schultz Michala Dalsgaard , Alstrup Morten , Olsen Markus Harboe , Berg Ronan M. G. , Mehlsen Jesper , Møller Kirsten , Gunge Riberholt Christian 
Published: April 2023

AbstractPatients with severe traumatic brain injury (TBI) may have autonomic dysfunction, one manifestation of which is orthostatic intolerance. This potentially impairs physical rehabilitation. However, the exact mechanisms remain elusive. In 30 patients participating in a trial of early tilt training versus standard care and 15 healthy volunteers, 5‐min electrocardiography was recorded in the supine position and during 70° head‐up tilt. Heart rate variability was analyzed by the low‐ and high‐frequency (LF and HF) power, the LF–HF ratio, the total power, the ratio of the standard deviation of normal‐to‐normal intervals (SDNN), the root mean square of successive differences (RMSSD), the detrended fluctuations, and sample entropy. In patients in the upright compared to the supine position, SDNN (p < 0.001), RMSSD (p < 0.001), and total power (p = 0.004) all decreased, while the remaining variables were unchanged; no long‐term differences in heart rate variability in the supine position were found between early tilt training and standard care. In the healthy volunteers, all measures besides SDNN and total power changed significantly between supine and upright position. In patients with severe TBI compared to healthy volunteers, several measures of heart rate variability changed differentially during mobilization from the supine to the upright position.
Towards a theory of syntactic workspaces: neighbourhoods and distances in a lexicalised grammar
Authors: Krivochen Diego Gabriel 
Published: April 2023

AbstractRecent work on structure building and mapping in Minimalist syntax makes explicit reference toworkspaces; however, it is still an underexplored area. This paper is an attempt to (a) analyse the notion of ‘workspace’ as used in current Minimalist syntax and (b) provide a definition of ‘syntactic workspace’ that can help us capture interesting empirical phenomena. In doing this, we confront set-theoretic and graph-theoretic approaches to syntactic structure in terms of the operations that can affect syntactic objects and how their properties are related to the definition of workspace. We analyse the consequences of conceptualising ‘syntax’ as a set of operations that affect local regions of the workspace, defining directed graphs.
A small RNA system ensures accurate homologous pairing and unpaired silencing of meiotic chromosomes
Authors: Tabara Hiroaki , Mitani Shohei , Mochizuki Megumi , Kohara Yuji , Nagata Kyosuke 
Published: April 2023

AbstractDuring meiosis, chromosomes with homologous partners undergo synaptonemal complex (SC)‐mediated pairing, while the remaining unpaired chromosomes are heterochromatinized through unpaired silencing. Mechanisms underlying homolog recognition during SC formation are still unclear. Here, we show that the Caenorhabditis elegans Argonaute proteins, CSR‐1 and its paralog CSR‐2, interacting with 22G‐RNAs, are required for synaptonemal complex formation with accurate homology. CSR‐1 in nuclei and meiotic cohesin, constituting the SC lateral elements, were associated with nonsimple DNA repeats, including minisatellites and transposons, and weakly associated with coding genes. CSR‐1‐associated CeRep55 minisatellites were expressing 22G‐RNAs and long noncoding (lnc) RNAs that colocalized with synaptonemal complexes on paired chromosomes and with cohesin regions of unpaired chromosomes. CeRep55 multilocus deletions reduced the efficiencies of homologous pairing and unpaired silencing, which were supported by the csr‐1 activity. Moreover, CSR‐1 and CSR‐2 were required for proper heterochromatinization of unpaired chromosomes. These findings suggest that CSR‐1 and CSR‐2 play crucial roles in homology recognition, achieving accurate SC formation between chromosome pairs and condensing unpaired chromosomes by targeting repeat‐derived lncRNAs.
Axin2 coupled excessive Wnt‐glycolysis signaling mediates social defect in autism spectrum disorders
Authors: Wang Mengmeng , Xian Panpan , Zheng Weian , Li Zhenzhen , Chen Andi , Xiao Haoxiang , Xu Chao , Wang Fei , Mao Honghui , Meng Han , Zhao Youyi , Luo Ceng , Wang Yazhou , Wu Shengxi 
Published: April 2023

AbstractSocial dysfunction is the core syndrome of autism spectrum disorder (ASD) and lacks effective medicine. Although numerous risk genes and relevant environmental factors have been identified, the convergent molecular mechanism underlying ASD‐associated social dysfunction remains largely elusive. Here, we report aberrant activation of canonical Wnt signaling and increased glycolysis in the anterior cingulate cortex (ACC, a key brain region of social function) of two ASD mouse models (Shank3−/− and valproic acid‐treated mice) and their corresponding human neurons. Overexpressing β‐catenin in the ACC of wild‐type mice induces both glycolysis and social deficits. Suppressing glycolysis in ASD mice partially rescued synaptic and social phenotype. Axin2, a key inhibitory molecule in Wnt signaling, interacts with the glycolytic enzyme enolase 1 (ENO1) in ASD neurons. Surprisingly, an Axin2 stabilizer, XAV939, effectively blocked Axin2/ENO1 interaction, switched glycolysis/oxidative phosphorylation balance, promoted synaptic maturation, and rescued social function. These data revealed excessive neuronal Wnt‐glycolysis signaling as an important underlying mechanism for ASD synaptic deficiency, indicating Axin2 as a potential therapeutic target for social dysfunction.
Pragmatic orientation of syntax in spontaneous speech: A corpus-based comparison between Brazilian Portuguese and Italian adverbial clauses
Authors: Bossaglia Giulia 
Published: April 2023

This paper reports on the syntax of finite adverbial clauses in spoken Brazilian Portuguese (BP) and Italian (IT), based on C-ORAL-BRASIL and Italian C-ORAL-ROM corpora and founded onLanguage into Act Theory (L-AcT: Cresti 2000). The analysis of adverbial clauses here is mainly focused on the syntax/pragmatics and syntax/information structure interfaces, aiming to show significant differences in the syntax of spoken versus written language.
The role of duration and intensity factors in the characterization of modal intonation in Brazilian Portuguese spoken in the North of Brazil. Exploration of AMPER-POR data.
Authors: Cruz Regina , Rilliard Albert 
Published: April 2023

The major aim of the current paper is to present an individual analysis of two physical parameters – duration (ms) and intensity (dB) – on four survey areas of Brazilian Portuguese spoken in the north of Brazil: Belém, Baião, Mocajuba and Curralinho. The selected data for this analysis stem originally from AMPER-POR database normalized by z-score. Formerly, statistics analysis has shown that duration and intensity play a secondary role in the modal intonation characterization. These results comply with the main analysis performed on intensity in prosody studies of Portuguese by the AMPER project where it emerges not as strong parameter in modal intonation discrimination. Contrastingly, ‘duration’ has shown up as a vigorous physical parameter for the characterization of modal intonation.
I think we need…: Verbal expressions of opinion in conference presentations in English and in French
Authors: Hartwell Laura , Esperança-Rodier Emmanuelle , Tutin Agnès 
Published: April 2023

This paper examines the frequency and functions of English and French opinion markers in 60 presentation transcripts of the EIIDA corpus in Linguistics and in Chemistry, Geochemistry, Marine, and Water Sciences. These functions, found in all four sub-corpora, include highlighting a general or strong opinion, proposing a hypothesis or negotiating with the audience, expressing doubt, or classifying information. Several important differences can be observed. First, the English verb think frequently functions as a discourse marker, more so than the French penser. In French, adverbials, the pronoun on and the conjunction que are frequent with an opinion verb, but were largely absent in English. In Linguistics, English speakers are more likely to express the subjective opinion that a result is “interesting”, whereas in the other three sub-corpora speakers are more likely to employ a modal verb, except with think, to hedge a statement. As regards to discipline, there appears to be slightly more markers of opinion in Linguistics. In the Sciences, markers of opinion are often related to an observation (on se rend compte, ‘one realizes’). Overall, opinion verbs tend here to be dialogic, serving to express doubt or to negotiate with the audience, rather than to confirm a forceful personal position.Keywords: oral academic discourse, opinion, English, French
Effects of virtual music therapy on Burnout Syndrome in health workers in Tertiary Hospitals
Authors: Ardani Yanuar , Putranto Rudi , Yunir Em , Koesnoe Sukamto , Muhadi  , Shatri Hamzah , Mansyur Muchtaruddin , Oliviera Ivona , Anggono Rendi Faris , Putri Kezia 
Published: April 2023

Background: Health workers are vulnerable to experiencing psychological and physiological stress, including burnout syndrome (BOS). BOS can be measured using the Maslach Burnout Inventory (MBI) assessment. BOS can also affect heart rate variability (HRV). Music therapy is one of the BOS therapies in the recovery phase. This study aims to evaluate the effects of virtual music therapy on "Burnout Syndrome" in health workers in Tertiary Hospitals
Methods: This research is a qualitative study and a randomized control trial using a pre-and post-test control group study design on healthcare workers at Dr. Kariadi Hospital and Dr. Cipto Mangunkusumo Hospital for three months. Subjects were divided into two groups, namely the intervention group and the control group, each consisting of 20 people. The instruments used were the MBI-HSS questionnaire and heart rate variability measuring devices for the pretest and posttest. Depending on the data distribution analysis performed using the Shapiro-Wilk test, data analysis was performed using either the Mann-Whitney test or the independent T-test. Data were analyzed using SPSS version 21.0 for Windows.
Results: This study shows significant differences in the MBI-HSS scores between the intervention and control groups (p<0.05). In the HRV-SDNN scores, there were only significant differences in the control group (p<0.05), although there was an increase in the mean values in the intervention group.
Conclusion: The use of music therapy according to culture and individual preferences can significantly affect the MBI-HSS score, which indicates burnout and increases the HRV value.
Photothermal switch of drug release from polydopamine-modified nanosheets
Authors: Shimizu Ken , Takeoka Shinji 
Published: April 2023

AbstractColorectal cancer, which is difficult to treat and has a high recurrence rate, is a challenging target. Here, we propose a novel multi-layered sheet-like device with photothermal switching for the achievement of both hyperthermia and local chemotherapy. The device was fabricated by modifying polydopamine on the surface of a polymer thin film (nanosheet) and combining it with a drug-loaded poly(lactic acid) nanosheet, and was demonstrated to control the drug release reversibly. It is suggested that several percent of loaded drug was repeatedly released by irradiating near-infrared light, indicating the high potential of minimally invasive long-term treatment of colorectal cancer.

Graphical abstract
Asociación entre la composición elemental del suelo y la planta y la morfología de Dasylirion cedrosanum Trel.
Authors: Serafín-Higuera Emir Lenin , Reyes-Valdés M. Humberto , Morales-Díaz América Berenice , Villarreal-Quintanilla José Angel , Benavides-Mendoza Adalberto 
Published: April 2023

Antecedentes: La producción de sotol ha crecido en los últimos años. Existe el interés de establecer monocultivos para mitigar la sobreexplotación de las poblaciones silvestres. Sin embargo, para un establecimiento y manejo eficiente de plantaciones es importante conocer la composición elemental de Dasylirion cedrosanum.
Hipótesis: La composición mineral de Dasylirion cedrosanum refleja la composición mineral de la solución del suelo del sitio en donde crece.
Especie de estudio: Dasylirion cedrosanum Trel.
Sitios y años de estudio: Se muestrearon plantas y suelos durante septiembre y octubre del 2020 en San Lorenzo, Buenavista y General Cepeda, Coahuila.
Métodos: Se colectaron tallos, hojas y suelos y se analizaron sus elementos. Además, se midieron caracteres morfológicos a cada espécimen. Los datos se analizaron con técnicas estadísticas multivariadas.
Resultados: El Ca y N presentaron alta concentración en el suelo y en las plantas. En las tres localidades los niveles de Se fueron altos en las plantas. No obstante, el Se en la solución del suelo no fue detectable. Los individuos de San Lorenzo y General Cepeda mostraron niveles altos de Cu y Ba, a pesar de que el Cu no fue detectable en el suelo. El crecimiento mostró asociación negativa con el As, Ba, Cd, Cr, Mo, Ni y Pb y el Mg estuvo relacionado con un mayor crecimiento de Dasylirion cedrosanum.
Conclusiones: Dasylirion cedrosanum dispone de mecanismos para la adquisición y concentración de los elementos de la solución del suelo, incluso cuando estos estén en concentraciones bajas.
Impact of COVID-19 pandemic on elementary school children’s sleep hygiene
Authors: Luma Nita Beluli 
Published: April 2023

The effect on sleep in elementary school-age, healthy children during the pandemic has been studied in various online survey studies with varied conclusions. However, no research study has been conducted in North Macedonia to examine the impact of the pandemic on the prevalence of sleep problems among elementary school-age children. Therefore, the present study is focused on exploring sleep patterns, sleep disturbances, and other associated factors during the COVID-19 pandemic outbreak in elementary school children. Approximately 85 respondents were surveyed from a public elementary school in North Macedonia. The Children Sleep Habits Questionnaire was used to assess children's sleep habits. From the research, we were able to conclude that children aged 7-8, are more prone to experiencing few sleep subscales that relate to common sleep problems such as bedtime resistance, sleep anxiety, night waking, and parasomnia while children at aged 10-11 would perform more sleep onset delays than younger ones.
Keywords: children's mental health, sleep patterns, sleep health, sleep disruptions, COVID-19.
The Protection Relay Coordination Studies (Over Current Relays and Ground Fault Relays) On The Power Plant Electrical System, PT. Rekind Daya Mamuju By Using The ETAP 12.6 Program
Authors: S Fatma 
Published: April 2023

Abstract-, This research is an ex-post facto descriptive study, which aims to determine: a) the results of the safety relay coordination settings (OCR and GFR) and b) the working sequence and operating time of the safety relay when a disturbance occurs in the electrical system of PT. Rekind Daya Mamuju. Electrical system data obtained in the form of Single Line Diagram of PLTU Mamuju 2x25 MW, protection equipment data, and safety relay coordination data which are then processed and analyzed using the ETAP 12.6 program. The results showed that on the OCR inverse time curve the secondary side of the 0.4 kV transformer is set with a pickup current of 0.45 s, the primary side relay of the transformer is 6.3 kV 0.25 s and the relay is connected between unit I and unit II. 0.84 s. The GFR setting value for the definite time curve for the secondary side of the pickup current is 0.4 s, and the relay on the primary side is 0.2 s. The working time interval of the relay to break the disturbance is 0.3 s. Coordination of safety relays for PLTU Mamuju unit I and Unit II has worked well, with no overlapping or miss-coordination curve plot values. The sequence of work and the time of operation of the relay when a disturbance occurs is in the order of the simulation results with the coordinated setting values.

Keywords : Coordination; OCR; GFR; ETAP 12.6 Program
Microbial Quality of Paddy fields at Alfurat Alawsat Area, Iraq and the Effect of Milling Process on the Rice Contamination Level
Authors: Alhendi Abeer S. , Ali Aqeel M. , Mohammed Abeer K. 
Published: April 2023

Fifty-Four paddy samples, 45 soil samples, and nine irrigation water samples of some paddy fields at Alfurat Alawsat Area, Iraq were collected to investigate the microbial quality including total count bacteria (TCB), molds and yeast, total coliform (TC), and E. coli bacteria. Paddy samples were processed at the laboratory level to produce rice at 32 and 36 whiteness, and the microbial quality of the produced rice was conducted too. The results showed that all irrigation water samples were overpassed the FDA limit for E. coli. All paddy samples were exceeded the good limit of TCB, but no sample exceeded the acceptable limit. Most paddy samples were exceeded the FDA limit for molds and yeast, and few paddy samples exceeded the total coliform limit. The milling process reduced microbial levels for some samples, while the effect was undetectable for other samples. Ten rice samples at 32 whiteness and eight rice samples at 36 whiteness out of 13 paddy samples overpassed FDA and Iraqi Quality Standardization (IQS) for molds and yeast. All produced rice at both whiteness levels was exceeded the total coliform of IQS, while only six and three samples out of 13 rice samples at 32 and 36 whiteness respectively overpassed the FDA limit. In conclusion, paddy samples taken from Alfurat Alawsat fields were overpassed some microbial levels from fields without the effect of storage or milling processing. Irrigation water was probably the main source of fields’ contamination, therefore, the paddy fields need to be monitored and controlled in terms of their microbial contamination.
Estimating the chemical composition of secondary compounds of Iraqi wild Agaricus bellaniae characterized morphologically and genetically
Authors: Abdul-Qader Ziena M. , Chechan Rukiabaa A. , Al-Taweel Sudad k.M. 
Published: April 2023

This study, which is considered the first of its kind in the world and the Arab homeland, was carried out in the laboratory of mushroom production belonging to the Medicinal Plant Unit/ College Of Agricultural Engineering Sciences/ University of Baghdad during the period from July 21, 2016, to December 30, 2018, aiming to isolate and purify the mycelium of the wild isolation in addition to the genetic and morphological identification of the mushroom Agaricus bellaniae. The obtained pure isolation was tagged in the American National Center for Biotechnology Information (NCBI) with symbol MF987843.1, thus Iraq would be the second country in the world in which the mushroom is grown following the United States of America. The optimum temperature for the mycelium growth rate was also determined in the laboratory, as they ranged between 50 -60 ◦C. Furthermore, the dried fruit bodies were recognized qualitatively and quantitatively to identify their content of medicinally active compounds. Theyhave shown a high percentage of Linoleic acid (47.77%), total anti-oxidants, and total phenols in addition to the high content of essential chemicals including high protein percentage (44%), mineral elements- selenium in particular (0.369 ppm), and amino acid where glutamic and aspartic acids recorded the highest percentage, reached 4.02% and 2.226% respectively.
Preparing New Ceramic Membranes from Syrian Zeolite Coated with Silver Nanoparticles to Treatment Wells Water
Authors: Hammal Abdulrazzaq 
Published: April 2023

As a result of the exacerbation of the problem of water pollution, research was directed towards studying the treatment using ceramic membranes, which proved to be highly effective in treating all water sources. The research aims to study the possibility of preparing a new type of ceramic membranes from Syrian zeolite that was not previously used in this field. In this research, ceramic membranes were prepared from Syrian raw zeolite in several stages. Zeolite sample was characterized, grinded, mixed with boric acid, pressed to form desks, treated thermally according to experiment program, finally coated with silver nanoparticles. Specifications of prepared membranes were determined according to reference methods, effectiveness of prepared membranes were tested in well water handling, that water sample was filtrated through prepared membranes, and then it type MAC, so removal degree was 100%, While removal degree was 97% for bacterial strains on Agar with type PCA, 93% on Agar with type PDA which were conformed to Syrian standard /45 /2007.
Specifications of prepared membranes were determined according to reference methods, effectiveness of prepared membranes were tested in well water handling, that water sample was filtrated through prepared membranes, then it was Characterized after treatment.
Results showed that prepared zeolite membranes were high effectiveness through decrease chemical and microbial pollutants which were conformed to Syrian standard /45 /2007
Determining ACE-2 Level and Some Relevant Biochemical Parameters and studying the effect of Gender in Iraqi Diabetic Patients with Glomeruli and Renal Tubules Fibrosis as Early Prediction Marker
Authors: Ibrahim Reham Khuldon , Ghudhaib Kadhim K. , Allawi Ali Abdulmajid Dyab 
Published: April 2023

Diabetic kidney disease is an illness of the glomerulus that interferes with the glomerular filtration barrier (GFB), which is worked to enable kidney to selective purification of water and solutes in addition to limiting the movement of large macromolecules such as albumin. In the glomerular endothelium, mesangial cells, foot cells, and the brush border of the proximal tubules, ACE-2 is expressed and that the kidneys represent the highest-expressing region of this enzyme. Thus, the current study aimed to evaluate ACE-2 level in this case compared to healthy condition. The study Conducted with 120 male and female ranging in age (30-65) years old. Ninety patients with type 2 diabetes subdivided into three groups on the basis of ACR criteria including normoalbuminuria, microalbuminuria, macroalbuminuria (30 patients for each group) and 30 healthy people served as the control group, all visited Baghdad Teaching Hospital / Medical City and Al-Yarmouk Teaching Hospital, at the period between December 2021 and May 2022. ACE-2 levels were determined using the ELISA technique. Urea results showed significant differences between diabetic nephropathy in patient and control group in female cases but no significant differences in male patients with diabetic nephropathy and control group. Similar results were obtained in K ion. Also the results revealed significant differences in Na ion, ACR, eGFR, Urea, FBS, creatinine between diabetic nephropathy groups and healthy group.ACE-2 represents a good marker for early prediction in diabetic nephropathy case. ROC data analysis support the importance of ACE-2 in diagnosis of the studied disease case.