bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal stromal cell therapy for feline chronic gingivostomatitis: Long term experience
Authors: Soltero-Rivera Maria , Hart Sterling , Blandino Andrew , Vapniarsky Natalia , Arzi Boaz 
Published: April 2023

IntroductionMesenchymal stromal cells (MSC) therapy has emerged as a potential treatment option for refractory FCGS. However, there is a lack of long-term data on the use of MSC therapy in cats. This study aimed to evaluate the long-term safety and efficacy of MSC therapy for FCGS and investigate potential factors associated with treatment outcomes.MethodsThis study was a retrospective evaluation of 38 client-owned cats with refractory FCGS who received MSC therapy. Medical records, histopathology, and the Stomatitis Activity Disease Index (SDAI) were reviewed. Correlations of the long-term follow-up success rates with SDAI and cell line type used were conducted. A client survey was also performed to assess side effect occurrence, quality-of-life following treatment, and overall treatment satisfaction.ResultsLong-term follow-up ranged from 2 to 9 years post-MSC treatment. The overall positive response rate to MSC treatment was 65.5%, with 58.6% of cats exhibiting permanent improvement or cure. Adverse effects occurring during or immediately after treatment were noted in 34.2% of cases, the majority being transient, self-resolving transfusion-like reactions. No long-term adverse events were noted. No significant correlation in outcome was detected between allogeneic and autologous MSC treatment (p = 0.871) or the severity of the SDAI at entry (p = 0.848) or exit (p = 0.166), or the delta SDAI between entry and exit (p = 0.178). The status 6 months (none to partial improvement vs. substantial improvement to resolution) post-therapy was a predictor of long-term response (value of p &lt; 0.041). Most clients were satisfied with the treatment and outcomes, with 90.6% willing to pursue treatment again, given a similar situation.DiscussionThe results of this study support the use of both autologous and allogeneic MSC as an efficacious and safe therapeutic option for refractory FCGS.
Transcriptional Activation of a Pro-Inflammatory Response (NF-κB, AP-1, IL-1β) by the Vibrio cholerae Cytotoxin (VCC) Monomer through the MAPK Signaling Pathway in the THP-1 Human Macrophage Cell Line
Authors: Escartín-Gutiérrez Julio Rodrigo , Ponce-Figueroa Mariana , Torres-Vega Miguel Ángel , Aguilar-Faisal Leopoldo , Figueroa-Arredondo Paula 
Published: April 2023

This study describes, to some extent, the VCC contribution as an early stimulation of the macrophage lineage. Regarding the onset of the innate immune response caused by infection, the β form of IL-1 is the most important interleukin involved in the onset of the inflammatory innate response. Activated macrophages treated in vitro with VCC induced the activation of the MAPK signaling pathway in a one-hour period, with the activation of transcriptional regulators for a surviving and pro-inflammatory response, suggesting an explanation inspired and supported by the inflammasome physiology. The mechanism of IL-1β production induced by VCC has been gracefully outlined in murine models, using bacterial knockdown mutants and purified molecules; nevertheless, the knowledge of this mechanism in the human immune system is still under study. This work shows the soluble form of 65 kDa of the Vibrio cholerae cytotoxin (also known as hemolysin), as it is secreted by the bacteria, inducing the production of IL-1β in the human macrophage cell line THP-1. The mechanism involves triggering the early activation of the signaling pathway MAPKs pERK and p38, with the subsequent activation of (p50) NF-κB and AP-1 (cJun and cFos), determined by real-time quantitation. The evidence shown here supports that the monomeric soluble form of the VCC in the macrophage acts as a modulator of the innate immune response, which is consistent with the assembly of the NLRP3 inflammasome actively releasing IL-1β.
Two Arabidopsis Splicing Factors, U2AF65a and U2AF65b, Differentially Control Flowering Time by Modulating the Expression or Alternative Splicing of a Subset of FLC Upstream Regulators
Authors: Lee Hee Tae , Park Hyo-Young , Lee Keh Chien , Lee Jeong Hwan , Kim Jeong-Kook 
Published: April 2023

We investigated the transcriptomic changes in the shoot apices during floral transition in Arabidopsis mutants of two closely related splicing factors: AtU2AF65a (atu2af65a) and AtU2AF65b (atu2af65b). The atu2af65a mutants exhibited delayed flowering, while the atu2af65b mutants showed accelerated flowering. The underlying gene regulatory mechanism of these phenotypes was unclear. We performed RNA-seq analysis using shoot apices instead of whole seedlings and found that the atu2af65a mutants had more differentially expressed genes than the atu2af65b mutants when they were compared to wild type. The only flowering time gene that was significantly up- or down-regulated by more than two-fold in the mutants were FLOWERING LOCUS C (FLC), a major floral repressor. We also examined the expression and alternative splicing (AS) patterns of several FLC upstream regulators, such as COOLAIR, EDM2, FRIGIDA, and PP2A-b’ɤ, and found that those of COOLAIR, EDM2, and PP2A-b’ɤ were altered in the mutants. Furthermore, we demonstrated that AtU2AF65a and AtU2AF65b genes partially influenced FLC expression by analyzing these mutants in the flc-3 mutant background. Our findings indicate that AtU2AF65a and AtU2AF65b splicing factors modulate FLC expression by affecting the expression or AS patterns of a subset of FLC upstream regulators in the shoot apex, leading to different flowering phenotypes.
A Critical Investigation of Factors Influencing Ugandan Family-Owned Manufacturing Businesses’ Performance
Authors: Kwoba Tadeo Bwire , Ebewo Patrick Ebong 
Published: April 2023

Objective: This study investigated the role of resources, capabilities, entrepreneurial orientation, and stewardship on the performance of family-owned manufacturing businesses in Uganda to establish how a firm can identify the rare and valuable resources that simultaneously enable better performance levels and competitive advantage. Research Design & Methods: A qualitative study with 15 participants from six family manufacturing businesses using interviews. The transcribed data was analysed and grouped into themes. Findings: General management skills, financial management, marketing management, and technology benefits are key resources and capabilities that enhance the smooth operations of the family manufacturing businesses and play are pivotal in achieving better performance and sustainability. Secondly, it was found that proactiveness, risk management, and continuous evaluation and appraisals of their performance were practised among family-owned manufacturing businesses. Thirdly, decision-making systems and lines of authority, enabling them to constantly analyse market trends and know about competitors were in place. Lastly, although there are supporting programmes for the manufacturing industries to help family-owned manufacturing businesses acquire start-up resources and import raw materials, there still needs to be more consistency in implementing such support programmes in Uganda. Implications & Recommendations: Family business owners should embrace proactivity, risk management, and continuous evaluation and appraisals of business performance. Furthermore, a review of current government policies, particularly those about industry financing and labour management, is recommended. Contribution & Value Added: The study was the first attempt to examine the performance of family-owned manufacturing businesses in Uganda. An improved framework was developed for their entrepreneurial success.
Du sumaan ndiig au paludisme infantile : la dynamique des représentations en milieu rural sereer sinig (Sénégal)
Authors: Faye Sylvain 
Published: April 2023

Cet article examine, par le biais d’une recherche qualitative, le processus de construction des représentations populaires du sumaan ndiig
infantile chez les Sereer sinig de Niakhar au Sénégal. Il s’agit de montrer que les données biomédicales sont intégrées à ces représentations et d’examiner les modalités de cette intégration. Dans un contexte de brassages sociaux et d’ouverture, on note que la circulation des informations biomédicales — IEC (information, éducation, communication), médias, équipes de recherche, expériences migratoires — a eu un effet sur les représentations populaires : le moustique, ainsi que ses médiateurs, sont associés au sumaan ndiig, une maladie moins banalisée. La perception de la fièvre persistante est en mutation. Au-delà de l’effet des campagnes d’information, cette attitude est aussi déterminée par les expériences subjectives actuelles des familles face à cette maladie. Pourtant, la spécificité des représentations qui tournent autour de l’hivernage, de la vulnérabilité de l’enfant et de certains savoirs populaires reste encore évoquée dans les constructions étiologiques du paludisme. Ces passerelles établies, de manière syncrétique, entre ces divers référents font du paludisme une maladie en mutation dans les registres interprétatifs des parents.
Predicting Moral Elevation Conveyed in Danmaku Comments Using EEGs
Authors: Bao Chenhao , Hu Xin , Zhang Dan , Lv Zhao , Chen Jingjing 
Published: April 2023

Moral elevation, the emotion that arises when individuals observe others’ moral behaviors, plays an important role in determining moral behaviors in real life. While recent research has demonstrated the potential to decode basic emotions with brain signals, there has been limited exploration of affective computing for moral elevation, an emotion related to social cognition. To address this gap, we recorded electroencephalography (EEG) signals from 23 participants while they viewed videos that were expected to elicit moral elevation. More than 30,000 danmaku comments were extracted as a crowdsourcing tagging method to label moral elevation continuously at a 1-s temporal resolution. Then, by employing power spectra features and the least absolute shrinkage and selection operator regularized regression analyses, we achieved a promising prediction performance for moral elevation (predictionr = 0.44 ± 0.11). Our findings indicate that it is possible to decode moral elevation using EEG signals. Moreover, the small-sample neural data can predict the continuous moral elevation experience conveyed in danmaku comments from a large population.
Improving prevention measures for healthcare-associated urinary tract infections
Authors: Sursyakova K. I. , Safyanova T. V. 
Published: April 2023

Aim. To develop an algorithm for a comprehensive assessment of endogenous and exogenous factors and risks of urinary tract infections (UTI) to improve prevention measures in multidisciplinary healthcare organizations.Materials and methods. All patients included in the study were divided into two groups. Group 1 was formed on the basis of the Altai Regional Hospital for War Veterans (700 medical histories). Regional Clinical Hospital provided 500 medical histories. Endogenous and exogenous risk factors were assessed in patients included in the study.Results. Following a comprehensive assessment of exogenous and endogenous risk factors of healthcare-associated UTI among patients of different ages, an algorithm for improving prevention measures has been developed.Conclusions. The algorithm of prevention measures for expert evaluation of risk factors and groups of healthcare-associated UTI enables the prevention of these infections to be improved. The creation of databases of risk factors that contribute to infection is essential for providing expert evaluation of standard operating procedures and internal quality audits of medical activities, as well as for determining the optimal prevention measures reducing the incidence of UTIs.
Evaluating etiological significance of <i>Enterococcus faecalis</i> isolated from children with urinary tract infection
Authors: Komenkova T. S. , Zaitseva E. A. 
Published: April 2023

Aim. To conduct comprehensive evaluation of microbiological properties of Enterococcus faecalis, isolated from urine in children with urinary system infections (UTI), to determine their etiological significance.Materials and methods. The study employed clinical isolates E. faecalis (n = 51) from the urine of children aged 3 days to 17 years who were treated for urinary tract infection between 2013 and 2017. The biological properties of enterococci were evaluated by means of classical microbiological and up-to-date molecular genetic methods. Statistical processing of digital data was carried out using non-parametric methods.Results. Phenotypic and genetic heterogeneity of microbiological properties of the studied urinary enterococci isolates was revealed. Using statistical methods of analysis, the authors established significant correlations between pathogenicity genes, antibiotic resistance and phenotypic manifestations of biological properties in urinary isolates E. faecalis. The results of evaluating the phenotypic manifestations of biological properties and the presence of certain genes enabled the enterococci to be classified into groups that correlated with certain sequence types (ST). Based on the revealed relationships of some biological properties of urinary isolates E. faecalis with certain sequence types, the authors developed an algorithm for assessing etiologically significant and highly virulent E. faecalis isolated from the urine of children with UTI.Conclusions. A comprehensive determination of some, potentially relevant biological properties, of the pathogen – enzymatic activity associated with pathogenicity and biochemical activities, antibiotic resistance (not only at the phenotypic, but also at the genetic level) – allows for assessing the diagnostic value of urostams E. faecalis, isolated from the urine of children with UTI, which will contribute to a personalized approach to treatment of these patients.
Wound microflora and antibiotic resistance in burn patients
Authors: Potapov A. F. , Shamaeva S. H. , Ivanova A. A. , Semenova S. V. 
Published: April 2023

Aim. To explore the etiological structure of wound microflora and its antimicrobial susceptibility in burn patients treated in hospital burn departments.Materials and methods. The authors analyzed the microbiology testing results of 2354 wound exudates in samples of 1581 patients with severe burns who underwent treatment in the Burn Unit and Department of Anesthesiology, Resuscitation and Intensive Care of the Center for Emergency Medical Care of the Republic of Sakha (Yakutia) in the period from 2016 to 2020. Data processing and antibiotic resistance analysis were performed via AMRcloud online platform (Beta version, 05.07.2022).Results. Of the pathogens isolated in the burn wounds, Staphylococcus aureus accounted for 26.1%, Enterococcus faecalis – 24.5%, Pseudomonas aeruginosa – 11.9%, Klebsiella pneumonia – 9.4%, Acinetobacter baumannii – 7.9% and Escherichia coli – 6.0%. The susceptibility of isolated microbial strains to carbapenems and high resistance to cephalosporins and fluoroquinolones were established.Conclusion. Microbial strains detected in burn patients indicate infection of wounds with representatives of nosocomial flora and their high resistance to commonly used antibiotics.
Critical Discourse Analysis in the Education Community to Respond the Hoax Based on Technology and Information
Authors: Muhammadiah Mas’ud , Tannuary Arwin , Romadhianti Rona , Fatmawati Endang , Herman Herman 
Published: April 2023

The research looked at how people in the Education community responded to the hoax phenomenon from the point of view of technology and information. This research aims to improve the educational component's ability to analyse different kinds of information or news. This will make it less likely that fake information will be used as a talking point or a guide. The method used is qualitative with critical discourse analysis, where the program's implementation is through the ASSURE method. The number of respondents is 60 consisting of teachers, parents and students in the sixth grade of an elementary school in Medan city. The technique used by researchers to gather data involves grouping various data, processing it in accordance with the aim to be recorded, and then deconstructing it using an essential conversation investigation preparation software created using the ASSURE approach. The technique of analyzing data was by implementing the six stages in the ASSURE model, which represent three other stages: pre-program, program implementation and post-program. The results show that critical discourse analysis through the basic conversation investigation program using the ASSURE method has proven to be effective and can be used to prevent the spread of hoax information that can cause various disputes.
Teaching Speaking Model in Student Exchange MBKM Program in Indonesian Universities
Authors: La'biran Roni , Dewi Resnita 
Published: April 2023

The goal of this research is to obtain a model in teaching speaking in Students Exchange MBKM program between PBSI Universitas Pancasakti Tegal and PBSI UKI Toraja. This research applies qualitative research. Sampling of data is students and lecturer PBSI from the University of Pancasakti Tegal, and Universitas Kristen Indonesia Toraja the research use total sampling. The instrument of this research used observation, interview, and questionnaire. In data analysis, researchers used qualitative methods. The results showed model of teaching speaking in students exchange MBKM program was Illustration, Interaction, Induction (III), Presentation, Practice, Production (PPP), and Mastery Learning. From the three models obtained based on field data, the model can be constructed into Contraction, Stimulation, Explanation, Demonstration, and Assessment.
PENERAPAN METODE CEPAT MENGHAFAL PERKALIAN UNTUK ANAK DI SEKOLAH DASAR
Authors: Hani Siti Umi , Pandji Vioneta Cattravelly , Hikmah Nurul , Rahmat Abdul , Wahab Abdul 
Published: April 2023

Tujuan dari dilakukannya observasi ini adalah untuk memudahkan siswa dalam mempelajari dan menghafal perkalian 1 Hinga 10 kenyataannya masih banyak siswa yang belum begitu memahami dan menghafal perkalian untuk anak sekolah dasar kelas 4 hingga 6. Oleh karena itu untuk memudahkan siswa dalam menghafal perkalian 1 hingga 10 tahap pertama yang lakukan adalah pendekatan, tahap kedua adalah menerapkan metode cepat pada pembelajaran perkalian, tahap terakhir adalah pengetesan seberapa paham siswa dalam pembelajaran menggunakan metode cepat. Dalam observasi kali ini terdapat tiga orang anak masing-masing kelas 4, 5 dan 6 di Sekolah Dasar. Masing-masing siswa memiliki kesulitan yang sendiri-sendiri namun setelah menggunakan metode cepat lambat laun siswa menjadi hafal perkalian 1 hingga 10 dengan baik dan benar tanpa kesalahan sedikit pun.
First-principles calculations and device characterizations of formamidinium-cesium lead triiodide perovskite crystals stabilized by germanium or copper
Authors: Enomoto Ayu , Suzuki Atsushi , Oku Takeo , Fukunishi Sakiko , Tachikawa Tomoharu , Hasegawa Tomoya 
Published: April 2023

Abstract
To avoid formation of the photo-inactive δ-phase of formamidinium-cesium lead triiodide, copper or germanium was added to the perovskite compounds to stabilize the photoactive α-phase. It was found that the substitution of lead by germanium (Ge) or copper (Cu) provided the stabilization of the α-phase in the present work. The first-principles molecular dynamics calculations indicated that displacements of formamidinium molecules were suppressed by the Ge doping. X-ray diffraction results indicated that the Ge or Cu doping of the perovskite compounds could be effective for suppression the phase transition from α- to δ-phase.
ﺍﻟﺠﻬﻮﺩ ﺍﻟﻨﻘﺪﻳﺔ ﻟﺤﺎﺯﻡ ﺍﻟﻘﺮﻁﺎﺟﻨﻲ ﻓﻲ ﻛﺘﺎﺑﻪ ﻣﻨﻬﺎﺝ ﺍﻟﺒﻠﻐﺎء ﻭﺳﺮﺍﺝ ﺍﻷﺩﺑﺎء
Authors: Dr.. Majeed Ali Mahdi  
Published: April 2023

ﻋﻨدﻤﺎ ﻴﺠري اﻟﺤدﻴث ﺒﻴن طﻼب اﻷدب وﻨﻘﺎدﻩ ﺒﺨﺼوص اﻟﻨﻘـد أﻟﺘﻨظـﻴري واﻋﻼﻤﺔ / ﻴﻛون
ﺤﺎزم اﻟﻘرطﺎﺠﻨﻲ اﺤد أﻗطﺎﺒﻪ اﻟﺒﺎرزﻴن اﻟذي ﻴﺘﻤﺤور اﻟﺤدﻴث ﻋﻨدﻩ ٬ وﺘﺒﻘﻰ آ ارؤﻩ اﻟﻨﻘدﻴﺔ اﻟﺠرﻴﺌﺔ ٬
وﻨظ ارﺘﻪ اﻟﺼﺎﺌﺒﺔ ﻋن اﻟﺸﻌر وأﺼوﻟﻪ ٬ وطرق ﺒﻨﺎﺌﻪ ﻤﺤط إﻋﺠﺎب اﻟﺠﻤﻴﻊ ﻟﻛوﻨﻪ اﺴﺘﻘطب اﻟﻨظرﻴﺔ
اﻟﻨﻘدﻴﺔ ﻟﻠﺒﻼﻏﻴﻴن واﻟﻨﻘﺎد اﻟذﻴن ﺴﺒﻘوﻩ أﻤﺜﺎﻝ أﺒﻲ ﻫﻼﻝ اﻟﻌﺴﻛري وﻋﺒد اﻟﻘﺎﻫر اﻟﺠرﺠﺎﻨﻲ ٬ واﺒن
اﻷﺜﻴر واﻟﻌﻠوي ﺼﺎﺤب اﻟط ارز وﻏﻴرﻫم ٬ إذ ﻫﻀم ﻨظرﻴﺎﺘﻬم ﻓﻲ أﺼوﻝ اﻹﺒداع اﻷدﺒﻲ ﻓﻲ
ﻤﻴداﻨﻲ اﻟﺸﻌر ٬ واﻟﻨﺜر ٬ وﻟﻛﻨﻪ ﻟم ﻴﻘف ﻋﻨد ﺤدود اﻹﺘﺒﺎع ٬ وﻓﻲ ﻤﻴدان اﻟﺘﻠﻤذة ٬ ﺒﻝ اﺴﺘطﺎع ﺒﻌﻘﻠﻪ
اﻟﻔذ أن ﻴﻔﻴد ﻤن اﻟﻨﻘد اﻟﻴوﻨﺎﻨﻲ اﻟﻤﺘﻤﺜﻝ ﺒﺄﻗطﺎﺒﻪ اﻟﺜﻼﺜﺔ ٬ ﺴﻘ ارط ٬ وأﻓﻼطون ٬ وأرﺴطو ٬ وﻏﻴرﻫم ﻤن
ﻨﻘﺎد اﻟﻴوﻨﺎن واﻟروﻤﺎن أﻴﻀﺎً ٬ وﺴﺨر ﺜﻘﺎﻓﺘﻪ اﻟﻌرﺒﻴﺔ ﻤﻊ ﺜﻘﺎﻓﺘﻪ اﻻﻏرﻴﻘﻴﻪ ﻓ ازوج ﺒﻴن اﻟﻨﻘدﻴن ﻤﺴﺘﻔﻴداً
ﻤن ﺘﺴﺨﻴر ذوﻗﻪ اﻟﻔﻨﻲ ٬ واﺴﺘﻴﻌﺎﺒﻪ اﻟﻨظرﻴﺎت اﻟﻨﻘدﻴﺔ اﻟﻤﺨﺘﻠﻔﺔ ﻓﻛﺎن ارﺌداً ﻓﻲ ﻤﻴﺎدﻴن اﻟﺒﻨﺎﻴﺔ اﻟﺸﻌرﻴﺔ
٬ وﻫﻴﻛﻠﻴﺔ أﻟﻘﺼﻴدﻩ ٬ وﻟوﺤﺎﺘﻬﺎ اﻟﻤﺨﺘﻠﻔﺔ ٬ ﺒﻝ ﺘدﺒر اﻟﺸﻌر اﻟﻌرﺒﻲ ٬ وﻗ أرﻩ ﺒﺼﺒر وأﻨﺎة ﻗ ارءة ﻨﻘدﻴﺔ
ﺼﺎﺌﺒﺔ وﻗﻠب أﻨواﻋﻪ ٬ وﺨرج ﺒﺄﺤﻛﺎم ﺘﺘﻌﻠق ﺒﺎﻷﺴﻠوب اﻟﺸﻌري وطرق اﻟﻨظم ٬ وأﺴﺎﻟﻴب ﻓن اﻟﻘوﻝ ٬
وأﻨواع اﻟﻘﺼﺎﺌد ذات اﻟﻠوﺤﺔ اﻟواﺤدة ٬ وذات اﻷﻟواح اﻟﻤﺨﺘﻠﻔﺔ ٬ وطرق اﻻﻨﺘﻘﺎﻝ ﻤن اﻟﻤطﻠﻊ إﻟﻰ
اﻟﻤﻘدﻤﺔ ٬ إﻟﻰ اﻟﻐرض اﻷﺼﻠﻲ ٬ ﻓﺄﻋطﻰ اﻀﺎءات وﻫﺎﺠﺔ ﻋن اﻟﻤﻘدﻤﺔ وﻫﻴﻛﻠﻴﺔ اﻟﻘﺼﻴدة ٬ وﻋن
ﻤﻌﺎﻨﻲ اﻟﺸﻌر واﻟﻔﺎظﺔ ٬ وﻤوﺴﻴﻘﺎﻩ ٬ ﻤن وزن ٬ وﻗﺎﻓﻴﻪ ٬ وﻤوﺴﻴﻘﻰ داﺨﻠﻴﺔ ﺘﺘﻌﻠق ﺒطرق رﺼف
اﻟﻛﻠﻤﺎت واﺨﺘﻴﺎر ﻤﻔردات اﻟﻠﻐﺔ اﻟﺸﻌرﻴﺔ وﺘﺸﻛﻠﻬﺎ ﺒﺄﺴﻠوب ﻴﺠﻌﻝ اﻟﺸﻌر ﻤوﺴﻴﻘﻰ ﻤﺘواﺼﻠﺔ ٬ وأﻨﻐﺎﻤﺎ
ﺸﺠﻴﻪ ﻋذﺒﺔ وﻛﺎن ﻟﺤﺎزم أﻴﻀﺎ إﺴﻬﺎﻤﺎت ﻓﻲ ﺘﻌرﻴف اﻟﺸﻌر وﻨﺸوﺌﻪ ٬ وﺘطورﻩ ٬ وﻗﻀﺎﻴﺎ اﻟﺼدق
اﻟﻔﻨﻲ ٬ واﻟﻤﺤﺎﻛﺎة واﻟﺘﺨﻴﻴﻝ واﻟﻤﻌـﺎﻨﻲ اﻟﺠﻤﻬورﻴﺔ ٬ واﻟﻤﻌﺎﻨﻲ اﻟﺨﺎﺼﺔ ٬ ﻓﻛﺎﻨت أﺤﻛﺎﻤﻪ ﺸﺎﻤﻠﺔ وطرﻴﻘﺔ
ﻤﻌﺎﻟﺠﺎﺘﻪ اﻟﻨﻘدﻴﺔ ﻓذة ﺒﻌﻴدة ﻋن اﻟﺘﻨﺎوﻝ اﻟﺠزﺌﻲ ﻟﻠﺒﻴت اﻟواﺤد ٬ واﻟﻠﻔظﺔ اﻟواﺤدة ٬ أو اﻻﻫﺘﻤﺎم ﺒﻤﺴﺎﺌﻝ
اﻟﺴرﻗﺔ اﻟﺸﻌرﻴﺔ ﻛﻤﺎ ﻨﺠد ذﻟك ﻋﻨد ﺒﻌض ﻨﻘﺎدﻨﺎ اﻟﻘداﻤﻰ ٬ ﻏﻴر أن ﺒﻌض أﺤﻛﺎﻤﻪ اﻟﺠزﺌﻴﺔ اﻟﺘﻲ
ﺴﺒﻘت ﻋﺼرﻩ ٬ أﺜﺎرت ﺤﻔﻴظﺔ اﻟﻨﻘﺎد اﻟﻤﺤﺎﻓظﻴن ٬ وﻷن ﺤﺎزﻤﺎً اﺒﺘﻌد ﻋن ﺘﻬوﻴﻤﺎت اﻟﻛﻼم وﻋﻤوﻤﻴﺎت
ﺍﻟﺮﺩ ﻋﻠﻰ ﻣﻨﻜﺮ ﺍﻟﻤﻌﺎﺩ ﻓﻲ ﺍﻟﻘﺮﺁﻥ ﺍﻟﻜﺮﻳﻢ
Authors: Taher Ismail Amin  
Published: April 2023

اﻟﺤﻤـد ﷲ اﻟـذي أﻨﻬـﻰ ﺒـﺎﻟﻤوت آﻤـﺎﻝ اﻟﻘﻴﺎﺼـرة ٬ وأﺸـﻬد أن ﻻ إﻟـﻪ إﻻ اﷲ وﺤـدﻩ ﻻ ﺸـرﻴك ﻟـﻪ ٬
وأﺸـﻬد أن ﺴـﻴدﻨﺎ ﻤﺤﻤـداً ﻋﺒـدﻩ ورﺴـوﻟﻪ ٬ ﻟﻘـد أدى اﻷﻤﺎﻨـﺔ وﺒﻠﱠـﻎ اﻟرﺴـﺎﻟﺔ ٬ وﻨﺼـﺢ اﻷﻤـﺔ ﻓﻛﺸـف اﷲ ﺒـﻪ

اﻟﻐﻤﺔ ٬ وﻟﺒس ﻓﻰ ﺘﺒﻠﻴﻎ اﻟرﺴﺎﻟﺔ وﺘﻠﺒﻴﺔ ﻨداء اﷲ ﺴﺒﺤﺎﻨﻪ وﺘﻌﺎﻟﻰ ﺤﺘﻰ أﺘﺎﻩ اﻟﻴﻘﻴن.
أﻤﺎ ﺒﻌد:

اﻟﻤﻌـﺎد: رﻛـن ﻋظـﻴم ﻤـن أرﻛـﺎن اﻹﻴﻤـﺎن ﻻ ﻴﺼـﺢ اﻹﻴﻤـﺎن إﻻ ﺒـﻪ ٬ وﻤﻤـﺎ ﻻﺸـك ﻓﻴـﻪ أﻨـﻪ ﻟـو
اﺴﺘﻘر ﺤﻘﻴﻘﺔ اﻹﻴﻤﺎن ﺒﻬذا اﻟﻴوم ﻓﻲ ﻗﻠـب اﻟﻌﺒـد وﻋﻠـم ﻋﻠـم اﻟﻴﻘـﻴن أَﻨـﻪ؛ ﻤوﻗـوف ﺤﺘﻤـﺎً ﻴوﻤـﺎً (ﻤـﺎ)؟ ﺒـﻴن
ﻴـدي اﷲ ﺴـﺒﺤﺎﻨﻪ وﺘﻌـﺎﻟﻰ ﻟﻴﻘـوﻝ ﻟـﻪ: (( ا ْﻗـَأرْ َﻛﺘَﺎَﺒـ َك َﻛﻔَـﻰ ِﺒَﻨ ْﻔ ِﺴـ َك اْﻟَﻴـْوَم َﻋﻠَْﻴـ َك َﺤ ِﺴـﻴًﺒﺎ )) ( 1 ) دﻓﻌـﻪ ذﻟـك

اﻹﻴﻤـﺎن واﻟﻴﻘـﻴن واﻟﻌﻠـم إﻟـﻰ اﻻﺴـﺘﻘﺎﻤﺔ ﻋﻠـﻰ ﻤـﻨﻬﺞ اﷲ ﺴـﺒﺤﺎﻨﻪ وﺘﻌـﺎﻟﻰ ورﺴـوﻟﻪ اﻷﻛـرم ٬(  ) وأن اﷲ

ﺘﻌـﺎﻟﻰ ﻓطـر اﻹﻨﺴـﺎن ﺒوﺠـود ﻋـﺎﻟم اﻵﺨـر ﺒﻌـد اﻟﻤـوت وﺤﻴـﺎة أﺨـرى ﺒﻌـد ﻫـذﻩ اﻟﺤﻴـﺎة ٬ ﻟـذﻟك ﺠـﺎءت
اﻟرﺴﺎﻻت اﻟﺴﻤﺎوﻴﺔ ﻗﺎطﺒﺔ ﻤﺒﻴﻨـﺔ ﺤﻘﻴﻘـﺔ ذﻟـك اﻟﻴـوم وﻤﺒﺸـرة ﺒﺤﻴـﺎة أﺨـرى ﺒﻌـد اﻟﻤـوت ٬ وﺠﻌﻠـت ﻤﺼـﻴر
ﻛـﻝ إﻨﺴـﺎن ﻤـرﺘﻬن ﺒﻤـﺎ ﻗـدﻤت ﻴـداﻩ ﻓـﻲ اﻟﺤﻴـﺎة اﻟـدﻨﻴﺎ ٬ وﺠـﺎء اﻟﻘـرآن اﻟﻛـرﻴم وﻫـو ﺨـﺎﺘم اﻟﻛﺘـب اﻟﺴـﻤﺎوﻴﺔ
واﻓﻴـﺎً ﺒﺎﻷدﻟـﺔ واﻟﺒـ ارﻫﻴن اﻟﻘﺎطﻌـﺔ ﻋﻠـﻰ اﻟﻤﻌـﺎد واﻟﺠـ ازء ﻓـﻲ ﻨﻤـﺎذج ﺤﻴـﺔ واﻀـﺤﺔ ﺤﺘـﻰ ﻛﺄﻨﻨـﺎ ٕواﻴـﺎﻩ أرس

اﻟﻌﻴن. 

ﻨﺴـﺄﻝ اﷲ ﺴـﺒﺤﺎﻨﻪ وﺘﻌـﺎﻟﻰ أن ﻴﺠﻌـﻝ أﻋﻤﺎﻟﻨـﺎ ﺨﺎﻟﺼـﺔ ﻟوﺠﻬـﻪ اﻟﻛـرﻴم وأن ﻴﺘﻘﺒـﻝ ﻤﻨـﺎ ﺠﻤﻴﻌـﺎً
ﺼﺎﻟﺢ اﻹﻋﻤﺎﻝ. واﻟﺤﻤد ﷲ رب اﻟﻌﺎﻟﻤﻴن.
Penerapan CRM untuk Kemudahan Pelanggaran pada PT Semen Baturaja
Authors: Ruslan Stephanie , Rachmadi Muhammad 
Published: April 2023

Pada PT Semen Baturaja memiliki beberapa masalah yang muncul yaitu, perusahaan mengalami kesulitan dalam melakukan cross selling kepada klien, serta klien mengalami kesulitan dalam mengetahui data histori dari pembelian produk yang sudah dilakukan sebelumnya dan juga keluhan yang diberikan oleh klien kepada perusahaan tidak sampai kepada perusahaan. Berdasarkan masalah yang terjadi kepada perusahaan diusulkan suatu solusi untuk menyelesaikan masalah tersebut yaitu pembuatan suatu aplikasi customer relationship management (CRM) berbasis web dengan menggunakan metode Rational Unified Process yang bisa membantu menyelesaikan permasalahan yang terjadi dan meningkatkan pelayanan kepada klien. Hasil penelitian dari pembuatan aplikasi customer relationship management (CRM) berbasis web yaitu dapat memberikan kemudahan dalam mengelola semua data pelanggannya dan juga memberikan informasi terkait apa yang diinginkan oleh pelanggan serta sistem yang bisa mengatasi permasalahan yang ada pada PT Semen Baturaja.