bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment
Authors: Sun Yuting , Jin De , Zhang Ziwei , Zhang Yuehong , Zhang Yuqing , Kang Xiaomin , Jiang Linlin , Tong Xiaolin , Lian Fengmei 
Published: January 2023

AbstractDiabetic kidney disease (DKD) is more prevalent with an increase in diabetes mellitus. Oxidative stress is a major factor in the occurrence and progression of DKD. Defending against oxidative stress and restoring antioxidant defense might be key to preventing and treating DKD. The purpose of this article is to provide an explanation of how oxidative stress affects DKD, conduct a systematic review and meta-analysis on DKD, and examine the effect of antioxidants on the disease. An analysis of 19 randomized controlled trials showed that the use of antioxidants could reduce UAE (albumin excretion rate) in patients with DKD (SMD: − 0.31; 95% CI [− 0.47, − 0.14], I2 = 0%), UACR (urine albumin/creatinine ratio) (SMD: − 0.60; 95% CI [− 1.15, − 0.06], I2 = 89%), glycosylated hemoglobin (hbA1c) (MD: − 0.61; 95% CI [− 1.00, − 0.21], I2 = 93%) and MDA (malonaldehyde) (SMD:-1.05; 95% CI [− 1.87, − 0.23], I2 = 94%), suggesting that antioxidants seemed to have therapeutic effects in patients with DKD, especially in reducing proteinuria and hbA1c. The purpose of this study is to provide new targets and ideas for drug research and clinical treatment of DKD.
Molecular insights into sex-specific metabolic alterations in Alzheimer’s mouse brain using multi-omics approach
Authors: Strefeler Abigail , Jan Maxime , Quadroni Manfredo , Teav Tony , Rosenberg Nadia , Chatton Jean-Yves , Guex Nicolas , Gallart-Ayala Hector , Ivanisevic Julijana 
Published: January 2023

Abstract
Background
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by altered cellular metabolism in the brain. Several of these alterations have been found to be exacerbated in females, known to be disproportionately affected by AD. We aimed to unravel metabolic alterations in AD at the metabolic pathway level and evaluate whether they are sex-specific through integrative metabolomic, lipidomic, and proteomic analysis of mouse brain tissue.

Methods
We analyzed male and female triple-transgenic mouse whole brain tissue by untargeted mass spectrometry-based methods to obtain a molecular signature consisting of polar metabolite, complex lipid, and protein data. These data were analyzed using multi-omics factor analysis. Pathway-level alterations were identified through joint pathway enrichment analysis or by separately evaluating lipid ontology and known proteins related to lipid metabolism.

Results
Our analysis revealed significant AD-associated and in part sex-specific alterations across the molecular signature. Sex-dependent alterations were identified in GABA synthesis, arginine biosynthesis, and in alanine, aspartate, and glutamate metabolism. AD-associated alterations involving lipids were also found in the fatty acid elongation pathway and lysophospholipid metabolism, with a significant sex-specific effect for the latter.

Conclusions
Through multi-omics analysis, we report AD-associated and sex-specific metabolic alterations in the AD brain involving lysophospholipid and amino acid metabolism. These findings contribute to the characterization of the AD phenotype at the molecular level while considering the effect of sex, an overlooked yet determinant metabolic variable.
The internal mammary artery perforator flap for neck reconstruction after palliative resection of advanced anaplastic thyroid cancer: a case report
Authors: Amrillaeva Vera , Dralle Henning , Weber Frank , Deneken Frauke , Farzaliyev Farhad 
Published: January 2023

Abstract
Introduction
Defects of the neck after palliative resection of exulcerated tumors could be reconstructed with different skin flaps.

Case presentation
The present report describes the case of a 40-year-old Caucasian female patient with advanced anaplastic thyroid cancer. The exophytically growing, bad-smelling massive exulcerated tumor caused an esthetic defect, neck mobility restrictions, and mental state deterioration.

Primary diagnosis, interventions, and outcomes
Palliative debulking of the tumor was performed. The 10 × 5 cm skin defect of the neck was successfully reconstructed with an internal mammary artery perforator island flap. The donor site was closed primarily. The patient had an uneventful clinical course; the cosmetic results and mental state were very pleasing.

Conclusions
The present case illustrates that palliative resection of the tumor and plastic reconstruction of the neck defect promoted other treatments such as radiation or chemotherapy due to the improved local situation.
Jointly optimized design of distributed RS-coded spatial modulation by appropriate selection at the relay
Authors: Zhao Chunli , Yang Fengfan , Ullah Waheed , Guo Pengcheng 
Published: January 2023

AbstractThis paper proposes the distributed Reed–Solomon (RS)-coded spatial modulation (DRSC-SM) scheme over quasi-static Rayleigh fading channel. Two different RS codes are used, one having a smaller minimum distance at the source and the other having a larger minimum distance at the relay. In order to obtain an optimized code at the destination, a proper encoding strategy must be adapted at the relay. Thus, an efficient design approach is proposed that suitably selects the symbols at the relay. Using this optimized approach as a benchmark, another design is proposed to achieve reduced complexity. To jointly decode the source and relay RS codes, three different decoding algorithms known as the naive, smart and improved smart algorithms are presented. Monte Carlo simulated results reveal that the proposed DRSC-SM scheme utilizing the improved smart decoding algorithm outperforms its counterpart DRSC-SM scheme employing the naive and smart decoding algorithms under identical conditions. The simulation results also validate the superiority of the proposed DRSC-SM scheme over its corresponding coded noncooperative scheme under the same decoding algorithm.
The emerging scenario of immunotherapy for T-cell Acute Lymphoblastic Leukemia: advances, challenges and future perspectives
Authors: Caracciolo Daniele , Mancuso Antonia , Polerà Nicoletta , Froio Caterina , D’Aquino Giuseppe , Riillo Caterina , Tagliaferri Pierosandro , Tassone Pierfrancesco 
Published: January 2023

AbstractT-cell acute lymphoblastic leukemia (T-ALL) is a challenging pediatric and adult haematologic disease still associated with an unsatisfactory cure rate. Unlike B-ALL, the availability of novel therapeutic options to definitively improve the life expectancy for relapsed/resistant patients is poor. Indeed, the shared expression of surface targets among normal and neoplastic T-cells still limits the efficacy and may induce fratricide effects, hampering the use of innovative immunotherapeutic strategies. However, novel monoclonal antibodies, bispecific T-cell engagers (BTCEs), and chimeric antigen receptors (CAR) T-cells recently showed encouraging results and some of them are in an advanced stage of pre-clinical development or are currently under investigation in clinical trials. Here, we review this exciting scenario focusing on most relevant advances, challenges, and perspectives of the emerging landscape of immunotherapy of T-cell malignancies.
Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity
Authors: Wang Haichao , Ainiwaer Aisima , Song Yaxiang , Qin Ling , Peng Ai , Bao Hui , Qin Huanlong 
Published: January 2023

Abstract
Background
Chronic kidney disease (CKD) is a severe public health problem associated with a disordered gut microbiome. However, the functional alterations of microbiota and their cross talk with metabolism pathways based on disease severity remain unclear.

Results
We performed metagenomics and untargeted metabolomics in a cohort of 68 patients with CKD of differing severities and 20 healthy controls to characterize the complex interplay between the gut microbiome and fecal and serum metabolites during CKD progression. We identified 26 microbial species that significantly changed in patients with CKD; 18 species changed as the disease progressed, and eight species changed only in a specific CKD group. These distinct changes in gut microbiota were accompanied by functional alterations in arginine and proline, arachidonic acid, and glutathione metabolism and ubiquinone and other terpenoid-quinone biosynthesis pathways during CKD progression. Further metabolomic analyses revealed that the distributions of toxic and pro-oxidant metabolites from these four essential metabolic pathways varied in the feces and serum as CKD progressed. Furthermore, we observed a complex co-occurrence between CKD severity-related bacteria and the characterized metabolites from the four essential metabolic pathways. Notably, Ruminococcus bromii, fecal hydroquinone, and serum creatinine were identified as the main contributors to the integrated network, indicating their key roles in CKD progression. Moreover, a noninvasive model including R. bromii and fecal hydroquinone, L-cystine, and 12-keto-tetrahydro-LTB4 levels classified the CKD severity (area under the curve [AUC]: > 0.9) and had better performance than the serum creatinine level for mild CKD (AUC: 0.972 vs. 0.896).

Conclusions
Perturbed CKD severity-related gut microbiota may contribute to unbalanced toxic and pro-oxidant metabolism in the gut and host, accelerating CKD progression, which may be an early diagnostic and therapeutic target for CKD.
Dispositional employability and self-regulation in antisocial and prosocial personalities: different contributions to employability
Authors: Lisá Elena , Valachová Michaela 
Published: January 2023

AbstractThe manuscript is based on the dispositional approach of employability, dispositional personality trait theories (dark triad, light triad, HEXACO honesty-humility), and reinforcement sensitivity theory. The facet-focused analysis allowed a more targeted interpretation of the results about the contribution of dark/light personalities and self-regulation for employability and a deeper understanding of practical implications. We analyzed the mediating effect of the behavioral activating system (BAS drive) on antisocial and prosocial traits in predicting employability. The convenient research sample consisted of 343 students. Participants completed: The short dark triad, light triad, honesty-humility, dispositional employability, and BIS/BAS. Dark traits explained 17.5% of work/career resilience, 12% of work identity, 6.4% of career motivation, and 6.6% of openness to changes at work. Narcissism explained 20% of work/career resilience. Prosocial traits explained 19.7% of work/career resilience, 16.8% of work identity, 11.8% of career motivation, and 5.3% of openness to changes at work. Modesty explained 10% of career motivation variance. BAS drive mediates predictions of employability by prosocial and antisocial traits. Demanding attention from others and focusing on making a good impression are effective tools for employability. Prosocial traits significant for BAS drive-activated participants (believing in the goodness of people and avoiding fraud and corruption) can be supported in organizations by providing career growth opportunities.
The role of molecular oxygen (O2) and UV light in the anion radical formation and stability of TCNQ and its fluorinated derivatives
Authors: Bang Jieun , Park JaeHong 
Published: January 2023

AbstractWe report the electronic absorption spectroscopy of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and its fluorinated derivatives (F2TCNQ and F4TCNQ), well-known electron-accepting molecules in common organic solvents (toluene, chlorobenzene, acetonitrile, and ethanol) under controlled exposure to air (O2) and UV light. All compounds (FxTCNQ (x = 0, 2, 4)) were stable in a neutral state (FxTCNQ0) in toluene and chlorobenzene, even under both O2 and UV light. On the other hand, in EtOH, the formation of FxTCNQ·− was monitored upon controlled exposure to O2 or UV light. Especially in air-equilibrated ethanol upon the UV-illumination, efficient α,α-dicyano-p-toluoylcyanide anion (DCTC−) and its fluorinated derivatives were generated evinced by the absorption peak near 480 nm, whereas the reaction was shut off by removing O2 or blocking UV light, thereby keeping FxTCNQ·− stable. However, even in deaerated ethanol, upon the UV-illumination, the anion formation of TCNQ and its fluorinated derivatives (FxTCNQ·−, x = 0, 2, 4) was inevitable, showing the stability of FxTCNQ0 depends on the choice of solvent.
Impact of COVID-related policies on gunshot wound assault hospitalizations in the United States: a statewide time series analysis
Authors: Strassle Paula D. , Ko Jamie S. , Ponder Madison , Nápoles Anna María , Kinlaw Alan C. , Schiro Sharon E. 
Published: January 2023

AbstractBackgroundThe CDC recently reported that firearm homicide rates in the United States increased in 2020, particularly among Black/African American individuals and men 25–44 years old. It is unclear whether firearm hospitalizations also increased, and more importantly, what impact the COVID-19 pandemic and COVID-related policies had. Using the North Carolina Trauma Registry, a statewide registry of trauma admissions to eighteen North Carolina hospitals, we calculated weekly GSW hospitalization rates from 1/2019 to 12/2020, overall and stratified by race-ethnicity, age, and sex. Interrupted time-series design and segmented linear regression were used to estimate changes in weekly hospitalization rates over time after (1) U.S. declaration of a public health emergency; (2) statewide Stay-at-Home order; (3) Stay-at-Home order lifted with restrictions (Phase 2: Safer-at-Home); and (4) further lifting of restrictions (Phase 2.5: Safer-at-Home). Non-GSW assault hospitalizations were used as a control to assess whether trends were observed across all assault hospitalizations or if effects were specific to gun violence.FindingsOverall, 47.3% (n = 3223) of assault hospitalizations were GSW. Among GSW hospitalizations, median age was 27 years old (interquartile range [IQR] 21–25), 86.2% were male, and 49.5% occurred after the U.S. declared a public health emergency. After the Stay-at-Home order was implemented, weekly GSW hospitalization rates began increasing substantially among Black/African American residents (weekly trend change = 0.775, 95% CI = 0.254 to 1.296), peaking at an average 15.6 hospitalizations per 1,000,000 residents. Weekly hospitalization rates declined after restrictions were lifted but remained elevated compared to pre-COVID levels in this group (average weekly rate 10.6 per 1,000,000 at the end of 2020 vs. 8.9 per 1,000,000 pre-pandemic). The Stay-at-Home order was also associated with increasing GSW hospitalization rates among males 25–44 years old (weekly trend change = 1.202, 95% CI = 0.631 to 1.773); rates also remained elevated among 25–44-year-old males after restrictions were lifted in 2020 (average weekly rate 10.1 vs. 7.9 per 1,000,000). Non-GSW hospitalization rates were relatively stable in 2020.ConclusionsThe COVID-19 pandemic and statewide Stay-at-Home orders appeared to have placed Black/African American residents and men ages 25–44 at higher risk for GSW hospitalizations, exacerbating pre-existing disparities. Persistent gun violence disparities must be addressed.
Adsorptive removal of levofloxacin and antibiotic resistance genes from hospital wastewater by nano-zero-valent iron and nano-copper using kinetic studies and response surface methodology
Authors: Hamad Mohammed Taha Moustafa Hussien , El-Sesy Marwa E. 
Published: January 2023

AbstractIn the twenty-first century, water contamination with pharmaceutical residues is becoming a global phenomenon and a threat. Antibiotic residues and antibiotic resistance genes (ARGs) are recognized as new emerging water pollutants because they can negatively affect aquatic ecosystems and human health, thereby posing a complex environmental problem. These nano-adsorbents of the next generation can remove these pollutants at low concentrations. This study focuses on the chemical synthesis of copper oxide nanoparticles (CuONPs) and nano-zero-valent iron (nZVI) used as nano-adsorbents for levofloxacin removal from water samples and antibiotic-resistant genes. The CuONPs and nZVI are initially characterized by transmission electron microscopy, scanning electron microscopy, and X-ray diffraction. The levofloxacin adsorption isotherm on the CuONPS and nZVI shows the best fit with the Langmuir isotherm model, exhibiting correlation coefficients (R2) of 0.993 and 0.999, respectively. The adsorption activities of CuONPS and nZVI were fitted to a pseudo-second-order kinetic model with correlation coefficients (R2) of 0.983 and 0.994, respectively. The maximum levofloxacin removal capacity was observed at (89%), (84%), (89%), (88%) and (71.6) at pH 7 and adsorbent dose(0.06 mg/L), initial LEV concentration (1 mg/L), temperature 25 °C, and contact time 120 min for CuONPs. Removal efficiency was (91%), (90.6%), (91%), (89%), and (80%), at pH 7, adsorbent dose(0.06), initial LEV concentration (1 mg/L), temperature 35 °C, and contact time 120 min. The levofloxacin adsorption is an exothermic process for nZVI and CuONPs, according to thermodynamic analysis. A thermodynamic analysis indicated that each adsorption process is spontaneous. Several genera, including clinically pathogenic bacteria (e.g., Acinetobacter_baumannii, Helicobacter_pylori, Escherichia_coli, Pseudomonas_aeruginosa, Clostridium_beijerinckii, Escherichia/Shigella_coli, Helicobacter_cetorum, Lactobacillus_gasseri, Bacillus_cereus, Deinococcus_radiodurans, Rhodobacter_sphaeroides, Propionibacterium_acnes, and Bacteroides_vulgatus) were relatively abundant in hospital wastewater. Furthermore, 37 antibiotic resistance genes (ARGs) were quantified in hospital wastewater. The results demonstrated that 95.01% of nZVI and 91.4% of CuONPs are effective adsorbents for removing antibiotic-resistant bacteria from hospital effluent. The synthesized nZVI and CuONPs have excellent reusability and can be considered cost effective and eco-friendly adsorbents.
Graphical Abstract
Beehives possess their own distinct microbiomes
Authors: Santorelli Lorenzo A. , Wilkinson Toby , Abdulmalik Ronke , Rai Yuma , Creevey Christopher J. , Huws Sharon , Gutierrez-Merino Jorge 
Published: January 2023

Abstract
Background
Honeybees use plant material to manufacture their own food. These insect pollinators visit flowers repeatedly to collect nectar and pollen, which are shared with other hive bees to produce honey and beebread. While producing these products, beehives accumulate a considerable number of microbes, including bacteria that derive from plants and different parts of the honeybees’ body. Whether bacteria form similar communities amongst beehives, even if located in close proximity, is an ecologically important question that has been addressed in this study. Specific ecological factors such as the surrounding environment and the beekeeping methods used can shape the microbiome of the beehive as a whole, and eventually influence the health of the honeybees and their ecosystem.

Results
We conducted 16S rRNA meta-taxonomic analysis on honey and beebread samples that were collected from 15 apiaries in the southeast of England to quantify the bacteria associated with different beehives. We observed that honeybee products carry a significant variety of bacterial groups that comprise bee commensals, environmental bacteria and symbionts and pathogens of plants and animals. Remarkably, this bacterial diversity differs not only amongst apiaries, but also between the beehives of the same apiary. In particular, the levels of the bee commensals varied significantly, and their fluctuations correlated with the presence of different environmental bacteria and various apiculture practices.

Conclusions
Our results show that every hive possesses their own distinct microbiome and that this very defined fingerprint is affected by multiple factors such as the nectar and pollen gathered from local plants, the management of the apiaries and the bacterial communities living around the beehives. Based on our findings, we suggest that the microbiome of beehives could be used as a valuable biosensor informing of the health of the honeybees and their surrounding environment.
An economic incentive package to support the wellbeing of caregivers of adolescents living with HIV during the COVID-19 pandemic in South Africa: a feasibility study protocol for a pilot randomised trial
Authors: Carries Stanley , Mkhwanazi Zibuyisile , Sigwadhi Lovemore , Moshabela Mosa , Nyirenda Makandwe , Goudge Jane , Govindasamy Darshini 
Published: January 2023

AbstractBackgroundThe mental and financial strain linked to unpaid caregiving has been amplified during the COVID-19 pandemic. In sub-Saharan Africa, carers of adolescents living with HIV (ALHIV) are critical for maintenance of optimum HIV treatment outcomes. However, the ability of caregivers to provide quality care to ALHIV is undermined by their ability to maintain their own wellbeing due to multiple factors (viz. poverty, stigma, lack of access to social support services) which have been exacerbated by the COVID-19 pandemic. Economic incentives, such as cash incentives combined with SMS reminders, have been shown to improve wellbeing. However, there is a lack of preliminary evidence on the potential of economic incentives to promote caregiver wellbeing in this setting, particularly in the context of a pandemic. This protocol outlines the design of a parallel-group pilot randomised trial comparing the feasibility and preliminary effectiveness of an economic incentive package versus a control for improving caregiver wellbeing.MethodsCaregivers of ALHIV will be recruited from public-sector HIV clinics in the south of the eThekwini municipality, KwaZulu-Natal, South Africa. Participants will be randomly assigned to one of the following groups: (i) the intervention group (n= 50) will receive three cash payments (of ZAR 350, approximately 23 USD), coupled with a positive wellbeing message over a 3-month period; (ii) the control group (n= 50) will receive a standard message encouraging linkage to health services. Participants will be interviewed at baseline and at endline (12 weeks) to collect socio-demographic, food insecurity, health status, mental health (stigma, depressive symptoms) and wellbeing data. The primary outcome measure, caregiver wellbeing, will be measured using the CarerQoL instrument. A qualitative study will be conducted alongside the main trial to understand participant views on participation in the trial and their feedback on study activities.DiscussionThis study will provide scientific direction for the design of a larger randomised controlled trial exploring the effects of an economic incentive for improving caregiver wellbeing. The feasibility of conducting study activities and delivering the intervention remotely in the context of a pandemic will also be provided.Trial registrationPACTR202203585402090. Registry name: Pan African Clinical Trials Registry (PACTR); URL:https://pactr.samrc.ac.za/; Registration. date: 24 March 2022 (retrospectively registered); Date first participant enrolled: 03 November 2021