bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-based diets and total and cause-specific mortality: a meta-analysis of prospective studies
Authors: Mo Qiwang , Wu Jizhongrong , Lu Yi , Zhang Xiao 
Published: January 2025

ObjectiveThe adherence to plant-based diets has been shown to positively impact longevity by reducing the incidence and severity of lifestyle-related diseases. Previous studies on the association of plant-based dietary pattern, as evaluated by plant-based dietary index (PDI), healthy plant-based dietary index (hPDI) and unhealthy plant-based dietary index (uPDI), with mortality risk have reported inconsistent results. We performed the present meta-analysis to summarize evidence on this association and to quantify the potential dose–response relationship based on all available cohort studies.MethodsA comprehensive literature search and systematic review of relevant articles up to October 2024 was performed in PubMed and Scopus. The summary risk estimates (RR) with 95% confidence interval (CI) for the highest versus the lowest category of PDIs, hPDIs and uPDIs were calculated. Dose–response meta-analysis was also performed for studies reporting categorical risk estimates for at least three quantitative levels of PDIs, hPDIs and uPDIs.ResultsA total of 11 eligible cohort studies (13 datasets) were eventually included in this meta-analysis. Participants in the highest quintile of both the PDI and hPDI had a significantly decreased risk of all-cause mortality (pooled HRPDI = 0.85; 95% CI: 0.80–0.90; pooled HRhPDI = 0.86; 95% CI: 0.81–0.92) compared to participants in the lowest quintile. In contrast, the highest uPDI was associated with an increased risk of mortality (pooled HRuPDI = 1.20; 95% CI: 1.11–1.31). Dose–response meta-analysis showed that there was a non-linear relationship between PDI or hPDI level and all-cause mortality (p = 0.001 and p &lt; 0.001 for non-linearity, respectively). No evidence of a non-linear relationship was observed for uPDI (p = 0.596 for non-linearity).ConclusionGreater adherence to PDI or hPDI dietary pattern was associated with a lower risk of mortality, whereas uPDI dietary pattern was positively associated with mortality risk. Thus, promoting a plant-based dietary pattern may be a key strategy in improving public health and reducing the burden of diet-related mortality.
Clinical analysis of molecular typing of 146 cases of endometrial carcinoma
Authors: Zhang Bo , Zhou Dan , Zhang Shuo , Yan Jinbowen , Meng Qingwei , Lv Qiubo 
Published: January 2025

ObjectiveTo investigate the application of TCGA molecular typing in endometrial carcinoma, compare the relationship between molecular typing and clinicopathologic features, and provide a new idea for individual treatment of patients.MethodsA total of 146 EC patients who underwent surgical treatment and TCGA molecular typing in Beijing Hospital from December 2019 to March 2023 were collected. The clinicopathologic features, immunohistochemistry, and prognosis of the four TCGA molecular types were analyzed retrospectively.ResultAmong the 146 patients with endometrial cancer (EC), 8 patients (5.5%) exhibited the POLE hypermutant type, 29 patients (19.9%) displayed the MSI-H type, 94 patients (64.4%) presented the low copy-number type, and 15 patients (10.3%) manifested the high copy-number type. A comparative analysis of the four TCGA types and age yielded statistically significant results (p = 0.012). Notably, significant associations were observed between menopausal status, the expression of ER, PR, and the four TCGA types. However, no significant difference was observed in CA125 levels before surgery among the four TCGA types (p = 0.587). There were significant differences observed among the four TCGA types and pathological types, pathological grades, FIGO stage, lymph node metastasis, and LVSI. The progression-free survival (PFS) rates of patients with POLE hypermutation, MSI-H type, CNL type, and CNH type were 100%, 100%, 93.62%, and 73.3%, respectively. There was a statistically significant difference between the four groups(p=0.006). POLE mutant and MSI-H type patients have higher PFS, while high copy type patients have the lowest.ConclusionsTCGA molecular typing has feasibility and application value in the clinical application of endometrial cancer, and has a certain predictive effect on the prognosis of EC patients. It has a certain guiding significance for the individual treatment of patients with endometrial cancer.
Association between transarterial chemoembolization refractoriness and prognosis in Chinese patients with hepatocellular carcinoma: a large retrospective cohort study
Authors: Sun Qinxue , Wu Ziliang , Yin Xi , Li Feng , Liu Ri 
Published: January 2025

BackgroundHepatocellular carcinoma (HCC) is commonly treated with transarterial chemoembolization (TACE) in intermediate stages. Existing international definitions of TACE refractoriness may not fully suit Chinese patients. The Chinese College of Interventionalists (CCI) proposed a tailored definition, but its impact on HCC prognosis is still limited.MethodsThis study included 844 patients with Barcelona Clinic Liver Cancer (BCLC) stage B HCC from a multicenter dataset. Propensity score matching (PSM) was used to minimize baseline differences between the TACE-Refractoriness (n = 54) and TACE-Non-Refractoriness (n = 108) groups. Kaplan-Meier survival analysis and multivariate Cox regression models were performed to evaluate the association between TACE-Refractoriness and OS. Subgroup analyses were conducted across key clinical and tumor-related characteristics.ResultsKaplan-Meier survival analysis indicated that patients classified as TACE-Refractory exhibited significantly shorter OS compared to those categorized as TACE-Non-Refractory in both the original and matched cohorts (P &lt; 0.001). Furthermore, multivariate analysis identified TACE refractoriness as a significant predictor of poorer OS, yielding an adjusted hazard ratio (HR) of 5.96 (95% CI: 3.39-10.5, P &lt; 0.001). Subgroup analysis further demonstrated the robustness of these findings across subgroups, except in female patients (HR = 3.0, 95% CI: 0.72–12.52; P=0.131).ConclusionsCCI-defined TACE refractoriness is associated with reduced OS in patients with BCLC stage B HCC undergoing TACE.
Unveiling the role of SYNGR4 in breast cancer development: a novel target for immunotherapy
Authors: Ma Jie , Wang Hongtao , Gui Zhengwei , Yang Yuanrong 
Published: January 2025

IntroductionSYNGR4 is considered to be one of the causative genes for amyotrophic lateral sclerosis, but its role in breast cancer development has not been revealed.MethodsThe expression of SYNGR4 in a variety of malignancies including breast cancer was analyzed using Genotype Tissue Expression (GTEx) and the Cancer Genome Atlas (TCGA) databases and verified by specimens collected from our center. The effect of SYNGR4 on breast cancer prognosis was analyzed using bioinformatics and possible pathways by which this molecule affects breast cancer prognosis were explored. The effect of SYNGR4 on immune infiltration of breast cancer was analyzed using GSVA, and the effects of SYNGR4 on breast cancer proliferation, migration, and tumor-associated macrophage polarization in cancer foci were verified by cellular and animal experiments, respectively.ResultsSYNGR4 is highly expressed in a variety of malignant tumors, including breast cancer, and affects the prognosis of breast cancer patients. This may be a volatile effect through Organelle fission, chromosome segregation, nuclear division, etc. SYNGR4 overexpression affects breast cancer proliferation, migration, and tumor immune infiltration, and promotes breast cancer tumor-associated macrophage polarization toward M2.DiscussionSYNGR4 overexpression can affect the prognosis of breast cancer patients by promoting M2 polarization of tumor-associated macrophages in breast cancer, and this molecule may be a novel target for breast cancer immunotherapy.
Effects of a therapeutic suit based on myofascial meridians on postural control and balance in children with cerebral palsy: a multiple-baseline, single-subject study
Authors: Cruz Thalita Karla Flores , Souto Deisiane Oliveira , Capuchinho Rafhael Guimarães , Lima Arthur Felipe Barroso de , Nascimento Amanda Aparecida Alves Cunha , Silva Ianara Pereira , Santana Patrícia Aparecida Neves , Criscoullo Lia Constantino , Haase Vitor Geraldi 
Published: January 2025

AimTo investigate the effects of an intervention programme based on the TREINI Exoflex therapeutic suit on balance, postural control, activity, and participation outcomes in children with cerebral palsy (CP).MethodA multiple-baseline, single-subject A/B research design was used. Balance, postural control, mobility, activities of daily living (ADLs), and goal attainment measures were collected for four children with CP. The intervention was a programme designed for the use of a therapeutic suit, that is, the TREINI Exoflex. The 2-SD band and percentage of non-overlapping data methods were used to compare outcomes between the baseline and intervention phases.ResultsThe intervention improved balance and postural control in all four children. The scope of the intervention on activity and participation outcomes varied between children. All children showed improvements in at least one stipulated goal and two in mobility and ADLs. Improvements in goal achievement occurred mainly for balance-related goals, whereas behavioural goals were not achieved.ConclusionThe results of this study support the use of the TREINI Exoflex suit during functional activities by children with CP. Future research should examine the effects of this approach in children of different ages and at different functional levels.
Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia
Authors: Botero-Rosas Daniel , Agudelo-Pérez Sergio , Troncoso Gloria , Gómez Maria C. , Tuta-Quintero Eduardo 
Published: January 2025

ObjectiveRenal autoregulation, hemodynamic response, and endothelial dysfunction play significant roles in acute kidney injury (AKI) during perinatal asphyxia. A third mechanism of autoregulation, involving very low-frequency oscillations, has been described. This study aimed to evaluate the relationship between the power of the very low-frequency component of the Fast Fourier Transform (FFT) and AKI during therapeutic hypothermia (TH) treatment in neonates with perinatal asphyxia.Study designA retrospective longitudinal study was conducted on neonates with moderate and severe perinatal asphyxia. AKI was defined as a decrease of less than 33% in the serum creatinine level by day 3. The power of the very low-frequency component in the FFT was assessed by analyzing renal oxygen saturation using near-infrared spectroscopy (NIRS), focusing on a frequency band of approximately 0.01 Hz. Bivariate analyses were performed to explore the association between the power of the very-low-frequency component and AKI. The predictive ability of this component for AKI was evaluated using a receiver operating characteristic (ROC) curve. Additionally, a generalized estimating equation (GEE) was developed to investigate whether changes in the power of the very-low-frequency component during treatment differed according to the presence of AKI.ResultsA total of 91 patients were included in the study, of whom 15 (16.5%) developed AKI. Neonates with AKI exhibited a significantly lower power of the very low-frequency component on the second day of treatment (p = 0.001). This component demonstrated good predictive ability for AKI (ROC curve 0.77, 95% CI 0.63–0.90).ConclusionAmong neonates with perinatal asphyxia who developed AKI, a lower power of the very-low-frequency component in FFT (approximately 0.01 Hz) was observed on the second day of therapeutic hypothermia. This finding suggests that alterations in very-low-frequency oscillations may reflect endothelial dysfunction and contribute to the development of AKI, warranting further investigation in larger cohorts.
Ecological risk assessment of future suitable areas for Piper kadsura under the background of climate change
Authors: Li Shimeng , Li Yuanxin , Hu Mingli , Li Yankun , Yang Mingrong , Wang Shi , Yu Wei , Cheng Chunsong , Cheng Qiqing 
Published: January 2025

IntroductionPiper kadsura is a well-known medicinal plant that belongs to woody liana, possessing high therapeutic and economic value. The market demand of P. kadsura is huge, but its wild resources are scarce and artificial cultivation methods have not been established, which leads to a situation with strong contradiction and imbalance between supply and demand.MethodsIn this study, 303 sample of distribution data for P. kadsura in China were collected, 33 environmental variables related to terrain, climate and soil were analyzed and the suitable habitats of P. kadsura during various periods were predicted by MaxEnt model and ArcGIS software, aiming to provide a basis for scientific cultivation and effective utilization of resources.ResultsThe results indicated that precipitation and temperature were significant factors in the distribution of P. kadsura. The primary environmental variables influencing the potential distribution of P. kadsura were precipitation during the driest quarter (Bio17), annual precipitation (Bio12), mean diurnal range (Bio2), and annual temperature range (Bio7). Among them, precipitation of driest quarter (Bio17) was the most influential environmental variable for the distribution of P. kadsura with the range between 100.68 and 274.48 mm. The current distribution of P. kadsura is mainly located in the coastal areas of eastern and southern China, especially Guangxi, Guangdong, Zhejiang and Fujian, with a total area of 51.74 × 104 km2. Future climate change of global warming will lead to a reduction in the total suitable areas and high suitable areas under various climate scenarios. Especially in the SSP585 scenario, the total suitable area and the highly suitable area will be significantly reduced by 89.26% and 87.95% compared with the present during the 2090s.DiscussionOverall, these findings can provide useful references for the suitable areas’ determination of wild resources, optimization of artificial cultivation and scientific selection of high quality medicinal materials on P. kadsura.
Genome skimming provides evidence to accept two new genera (Apiaceae) separated from the Peucedanum s.l.
Authors: Song Bo-Ni , Liu Chang-Kun , Deng Jiao-Jiao , Tan Wei-Yan , Zhou Song-Dong , He Xing-Jin 
Published: January 2025

BackgroundThe Peucedanum s.l. genus, the backbone member of subfamily Apioideae, includes many medically and economically important plants. Although previous studies have proved that the genus was not a natural taxonomic unit and taxonomists also conducted several taxonomic revisions for taxa of this genus, classifications of numerous taxa of the genus still have not been satisfactorily resolved, especially for those endemic to China. Therefore, we conducted a comprehensive taxonomic revision of taxa within the polyphyletic Peucedanum s.l. genus in this study.MethodsWe used two molecular datasets (103 plastomes and 43 nrDNA sequences) generated by genome skimming to reconstructed a reliable phylogenetic framework with high support and resolution. In addition, we also investigated the divergence time of core clade of endemic taxa.Results and DiscussionBoth analyses failed to recover Peucedanum s.l. as a monophyletic group and robustly supported that P. morisonii, the representative of Peucedanum s.s., was distantly related to other Peucedanum s.l. members, which implied that these Peucedanum s.l. taxa were not “truly Peucedanum plants”. Among these Peucedanum s.l. members, plastid-based phylogenies recognized two monophyletic clades, clade A (four species) and clade B (10 taxa). Meanwhile, obvious recognized features for morphology, plastome, and chromosome number for each clade were detected: dorsally compressed and glabrous mericarps with filiform dorsal ribs, winged lateral ribs, numerous vittae in commissure and each furrow, IRa/LSC border falling into rpl23 gene, an overall plastome size of 152,288-154,686 bp, and chromosome numbers of 2n=20 were found in clade A; whereas dorsally compressed and pubescent mericarps with filiform dorsal ribs, winged lateral ribs, numerous vittae in commissure and each furrow, IRa/LSC border falling into the ycf2 gene, an overall plastome size of 146,718-147,592 bp, and chromosome numbers of 2n=22 were discovered in clade B. Therefore, we established two new genera (Shanopeucedanum gen. nov. and Sinopeucedanum gen. nov.) to respectively accommodate the taxa of clades A and B. Furthermore, molecular dating analysis showed that the diversification of clades A and B occurred in the early Pleistocene and late Pliocene, respectively, which may have been driven by the complex geological and climate shifts of these periods. In summary, our study impelled a revision of Peucedanum s.l. members and improved the taxonomic system of the Apiaceae family.
Factors of suicide-related behaviors based on stress-vulnerability model and prevention strategies among nurses: a scoping review
Authors: Yang Xiaoyu , Hu Deying , Li Lecheng , Rezak Rezvanguli 
Published: January 2025

ObjectiveThe objective of this scoping review was to explore, appraise and synthesize the current literature regarding the incidence, factors influencing, and prevention strategies related to suicide risk among nurses.MethodsAn extensive literature search was conducted using databases such as PubMed, Web of Science, Medline, and Embase from its formation to June 20, 2024, specifically focusing on the suicide-related behaviors of nurses written in Chinese or English. Two researchers independently screened the literature, and disagreements were debated until a consensus was reached. Data extraction was conducted for the studies that were included. The process of data synthesis was carried out using narrative analysis.ResultsThe study encompassed 40 papers from 15 different countries. This study found that nurses’ suicide ideation ranged from 4.3 to 44.58%, while suicide attempts ranged from 2.9 to 12.6%. Based on the stress-vulnerability model, factors influencing nurses’ suicide-related behaviors include vulnerability (personality traits, coping styles), stressors (mental disorders, workplace bullying, etc.) and protective factors (social support, resilience, etc.). The strategies for preventing nurse suicide encompass primary prevention (for all nurses), secondary prevention (for nurses at risk of suicide), and tertiary prevention (for nurses who have attempted suicide).ConclusionThe suicide rate among nurses exceeds that of the general population. Mental disorders and workplace bullying are significant stressors that contribute to nurse suicide. Suicide-related behaviors among nurses can be effectively prevented and managed through the implementation of the tertiary prevention strategies. Primary prevention is essential in reducing suicide. Cognitive exercises and schedule shifts reasonably are primary preventive measures tailored for nurses. This study addresses the gaps in influencing factors about suicide-related behaviors among nurses and the strategies for preventing suicide, and provides a complete review of the current situation of nurses’ suicide-related behaviors, providing references for the safe management of nurses’ suicide.
Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium
Authors: Labrenz Oliver , Waedel Lucie , Kölch Michael , Lezius Susanne , Wacker Christina , Fröhlich Antonia , Paschke Kerstin , Thomasius Rainer , Reis Olaf 
Published: January 2025

BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. In particular, children and adolescents who live in families that are part of the child and youth welfare system and receive support services are considered to be at high risk of developing mental disorders. It is less likely that these families will choose a therapeutic setting for the treatment of DMUD. The objective is to reduce DMUD-related symptoms and improve media use behaviour through the implementation of an app-based training programme.MethodsThe efficacy of Res@t digital, initially conceived as an adjunct to child and adolescent psychiatric treatment, is to be evaluated for n= 32 children and adolescents with a media use disorder or at risk of developing this disorder, and their families enrolled in child and youth welfare services. The efficacy of the app will be evaluated in a randomised controlled trial with a waitlist control group. The primary outcome is the reduction of DMUD symptoms over a 20-week period following the onset of app training. Secondary outcomes include EEG measurements and changes in standardised psychopathological variables.DiscussionShould the Res@t app prove efficacious when compared to a waitlist control group, it would constitute an evidence-based intervention for the treatment of DMUD in children and adolescents. For high-risk families, the app could serve as a motivational tool to prompt action regarding potential DMUD and facilitates access to therapeutic facilities.Clinical trial registrationhttps://drks.de, identifier DRKS00033379.
A mixed-methods systematic review of mental health activities among urban left-behind children in mainland China
Authors: Long Siyu , Madon Zainal Bin , Norowi Noris Mohd , Ang Mei Foong 
Published: January 2025

IntroductionThe mental health of left-behind children has garnered attention from Chinese scholars in recent years. Although several interventions have been implemented to address these children’s mental health in urban areas, a gap remains in understanding the types of interventions, their effectiveness, and the factors that act as barriers or facilitators during the implementation process.MethodsA mixed methods systematic review informed by JBI methodology. Researchers conducted a comprehensive search of databases in both English and Chinese, covering the years 2005 to 2023. The initial search took place in January 2024 and was updated in March 2024. This study includes all studies results available up to December 31, 2023. The protocol has been registered on PROSPERO (CRD42023384078) and includes 14 studies in the review.ResultsThe activity categories included group psychological activities, individual family activities and multiple formats services. Three barriers to implementation emerged: social workers, activities and parents. The facilitators were parents and activity design.ConclusionThis review revealed that some studies suffered from poor data collection methods and data quality. Studies on services for mental health in urban left-behind children requires methodologically robust study designs for broader dissemination and rigorous evaluation.Systematic review registrationPROSPERO, CRD42023384078, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023384078.