bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization method for rough- finish milling allowance based on depth control of milling affected layer
Authors: Xin Hongmin , Dong Maiming , Xian Chao , Cheng Qingsi , Dai Hui , Yao Changfeng , Cui Minchao , Li Xingtong 
Published: December 2022

Abstract
The optimization of machining allowance has an important influence on the machining quality of workpieces. This paper determined an optimization method for rough-finish milling allowance based on depth control of milling affected layer. Firstly, the coupling influence of rough-finish milling cutting depth on milling affected layer depth is studied by experiment. Secondly, the influence rule of rough milling and finish milling on the affected layer depth is studied by experiment, and the prediction model of the milling affected layer depth based on the cutting depth of rough milling and finish milling is established, as well as the surface roughness prediction model of the finish milling cutting depth. Finally, the effectiveness of the optimization results was verified by experiments. The experimental results show the optimized machining parameters can increase the machining efficiency by 31.2%, and the milling affected layer is 91 µm, which indicates that the depth of milling affected layer is effectively controlled.
Primary Empty Sella and Acromegaly: Case Series and Systematic Review
Authors: Sharifi Guive , Ohadi Mohammad Amin Dabbagh , Azadi Masoumeh , Jahanbakhshi Amin , Dilmaghani Nader Akbari , Mohammadi Essmail , Tehrani Mohammadreza Mohajeri , Hatami Neda , Banihashemi Gelareh , Zenonos Georgios A. , Smith Timothy R. 
Published: December 2022

Abstract
Purpose: Investigating Primary empty sella (ES) in patients with acromegaly for possible etiology, complications, and treatment options.
Method: We searched for primary ES, among 220 acromegaly patients referred to our center from 2013 to 2020. Data were collected from hospital records and were completed through phone calls with patients. Finally, we conducted a systematic literature review of previous reports for patients with primary ES and acromegaly who underwent transsphenoidal surgery.
Result: We found 31 patients with primary ES. The mean age was 46 years with a male to female ratio of 12:11. Surgical data was available for 23 patients. Total ES was found in 18 patients. Six patients had adenoma invasion into the clivus or sphenoid sinus. The tumor extended into the cavernous sinus in 10 patients. CSF leak was observed in three patients during surgery. Hormonal laboratory data were available for 17 patients. GH/IGF1 was controlled without any replacement therapy in nine patients. The most common simultaneous hormonal disturbance was high prolactin levels. No pituitary hormonal abnormalities occurred after transsphenoidal surgery except for hypothyroidism in one patient.
Conclusion: Primary ES is not an unusual finding in acromegaly patients. Transsphenoidal surgery as a first-line treatment carries a reasonable complication rate.
Endovascular treatment of large hemoptysis for pulmonary pseudoaneurysm: Report of 23 cases
Authors: Li Fen-Qiang , Su Dong-Jun , Zhang Wan-Jia , Chen Zhong-Ke , Li Geng-Xiang , Li Shuang-Xi , Peng Yu-xing , Dang Lei , Wang Wen-Hui 
Published: December 2022

Abstract
Purpose: To evaluate the safety and effectiveness of endovascular treatment for massive hemoptysis caused by pulmonary pseudoaneurysm (PAP).
Methods: The clinical data, imaging data, and endovascular treatment of 23 patients with massive hemoptysis caused by continuous PAP were retrospectively analyzed. The success, complication, postoperative recurrence rate, and influence of the treatment on pulmonary artery pressure were also evaluated.
Results：Nineteen patients with bronchial artery (BA) or NBSA-PA fistula underwent bronchial artery embolization (BAE) + non-bronchial systemic artery embolization (NBSAE) + pulmonary artery embolization (PAE). The pulmonary artery (PA) pressures before and after embolization were 52.11±2.12 (35-69 cmH2O) and 33.58±1.63 (22-44 cmH2O), respectively (P=0.001). Four patients did not have BA or NBSA-PA fistula. Embolization was performed in two patients with distal pulmonalis lobar arteria PAP. Bare stent-assisted micro coil embolization was performed in the other two patients with PAP of main pulmonalis lobar arteria. The PA pressures of the four patients before and after treatment were 24.50±1.32 (22-28 cmH2O) and 24.75±1.70 (22-29 cmH2O), respectively (P=0.850). The technique had 100% success rate with no serious complications and a postoperative recurrence rate of 30%.
Conclusion: Endovascular treatment is safe and effective for massive hemoptysis caused by PAP. The presence of BA or NBSA-PA fistula, BAE, or NBSAE can effectively reduce pulmonary hypertension.
Effectiveness of a theory-based behavior change intervention on physical activity in patients with chronic obstructive pulmonary disease
Authors: Xiang Xinyue , Han Maomao , Luo Xiaolin , Yu Yudi , Lu Xiaorong , Cai Shasha , Huang Lihua 
Published: December 2022

Abstract
Background:The aim of this study was to evaluate whether a theory-based behavior change intervention could promote changes in physical activity (PA) and sedentary behavior (SB) among patients with chronic obstructive pulmonary disease (COPD), as well as its effects on symptoms of dyspnea, lung function, exercise capacity, self-efficacy, and health-related quality of life (HRQoL).
Methods: A quasi-experimental design and convenience sampling were adopted. 92 patients with stable COPD were recruited from two hospitals in Zhejiang province, China. Both the experimental and control groups received usual care provided in the hospital. The control group received usual care only, while the experimental group performed a PA program based on the behavior change wheel theory. Outcomes were measured at baseline (T0), 4 weeks (T1), 8 weeks (T2), and 12 weeks of the intervention (T3). The primary outcome, PA, was measured by the International Physical Activity Questionnaire (IPAQ). Secondary outcomes included: sedentary behavior (SB) measured by the IPAQ, dyspnea measured by the modified Medical Research Council (mMRC) questionnaire, exercise capacity assessed by six minute walking test (6MWT), self-efficacy measured by the Exercise Self-Regulatory Efficacy Scale (EX-SRES), and HRQOL measured by the COPD Assessment Test (CAT). In addition, we measured lung function, using the Spirometer at baseline and 12 weeks.
Results: Of the 89 patients included in this study, 64 were male (71.91%); with a mean age of 67.03 ±6.15 years. At 12 weeks, the improvement of PA, SB, mMRC, 6MWT, EX-SRES and CAT were all statistically significant (P<0.05) in the experimental group compared to the control group.There was no difference between groups in lung function. Repeated measures analysis of variance showed that there were group effects and time effects on total PA, SB, mMRC, 6MWT, EX-SRES, and CAT in both groups (P<0.001).
Conclusion: PA program based on theoretical significantly improved PA, reduce sedentary time and promote healthy behavior change in patients with COPD. Due to the limited intervention time in this study, lung function in COPD patients may not be reversed in a short period of time, thus further research is necessary.
Trial registration: Clinical Trials.gov (ChiCTR2200060590).
Migration and invasion suppression by Taraxerol in Triple Negative Breast Cancer cell line MDA-MB-231 via ERK/Slug axis
Authors: XIA Yu-ting , ZHANG Yu-qin , CHEN Lu , MIN Liang-liang , HUANG Da , ZHANG Yu-lu , LI Cong , LI Zhi-hua 
Published: December 2022

Abstract
Taraxerol (TRX) is one of triterpenoid extracts from traditional Chinese medicine (TCM) Taraxacum, and its anti-tumor effect has been extensively proved. However, the effects and molecular mechanisms of TRX in Triple Negative Breast Cancer (TNBC) have not been illustrated completely. In this study, we found that TRX inhibited the migration and invasion of the TNBC cell line MDA-MB-231, and further identified 20 targets both closely related to TNBC and TRX through network pharmacology. Subsequently, analyzing these targets by GO and KEGG enrichment, and MAPK3 was the most potential candidate target. It was found by molecular docking that could combine stably with TRX, as well it was illustrated by experiments in vitro that could inhibit the migration and invasion of MDA-MB-231 cells by acting on Slug. Meanwhile, ERK activator (tert-Butylhydroquinone, tBHQ) could significantly reverse the suppression of TRX on the migration and invasion of MDA-MB-231 cells. In conclusion, TRX could inhibit the migration and invasion of MDA-MB-231 cells via ERK/Slug axis.
Efficacy and Safety of Catheter Ablation for Atrial Fibrillation in Patients with History of Cancer
Authors: Ganatra Sarju , Abraham Sonu , Kumar Ashish , Parikh Rohan , Patel Rushin , Khadke Sumanth , Kumar Amudha , Liu Victor , Diaz Andrea Nathalie Rosas , Neilan Tomas G. , Martin David , Hook Bruce , Dani Sourbha S. , Asnani Aarti , Nohria Anju 
Published: December 2022

Abstract
Background: Though the incidence of atrial fibrillation (AF) is increased in patients with cancer, the effectiveness of catheter ablation (CA) for AF in patients with cancer is not well studied.
Methods: We conducted a retrospective cohort study of patients who underwent CA for AF. Patients with a history of cancer within 5-years prior to, or those with an exposure to anthracyclines and/or thoracic radiation at any time prior to the index ablation were compared to patients without a history of cancer who underwent AF ablation. The primary outcome was freedom from AF, with or without anti-arrhythmic drugs (AADs), and need for repeat CA at 12-months post-ablation. Secondary endpoints included freedom from AF at 12 months post-ablation with AADs and without AADs. Safety endpoints included bleeding, pulmonary vein stenosis, stroke, and cardiac tamponade. Multivariable regression analysis was performed to identify independent risk predictors of the primary outcome.
Results: Among 502 patients included in the study, 251 (50%) had a history of cancer. Freedom from AF at 12 months did not differ between patients with and without cancer (83.3% vs 72.5%, p 0.28). Need for repeat ablation was also similar between groups (20.7% vs 27.5%, p 0.29). Multivariable regression analysis did not identify a history of cancer or cancer-related therapy as independent predictors of recurrent AF after ablation. There was no difference in safety endpoints between groups.
Conclusion: CA is a safe and effective treatment for AF in patients with a history of cancer and those with exposure to potentially cardiotoxic therapy.
WITHDRAWN: Linking public perspectives on watershed issues to indicators and how they differ between natural regions within the Red Deer River watershed, AB, Canada
Authors: Montemayor Marilou B. 
Published: December 2022

Abstract
Public consultation workshops were held at three locations that corresponded to natural regions within the Red Deer River watershed. Participants were asked what their watershed issues were. Issues were linked to watershed indicators used in the completed state of the watershed report (SOW) that would eventually be used in the future watershed management plan (WMP). Issues gathered were sorted, counted, averages calculated and ranked, and comparisons made between locations. Two main categories of issues were found: environmental and socio-economic. Issues under each category were sorted and these generated nine environmental and eight socio-economic watershed indicators. Three new environmental indicators were found, and a whole new set of socio-economic indicators. These indicators should be considered in the future WMP and the next SOW report. Natural regions influenced environmental indicators that in turn could influence socio-economic indicators. Dividing the large watershed (4,965,000 ha) using natural regions as management units could create a “common-place” for their respective communities and local governments; a step towards the place-based approach. The use of natural regions could facilitate the incorporation of biodiversity related plans and programs into a WMP. Public consultations were found useful and should be included in future watershed indicators selection processes. This study is relevant to places in the world that practice collaborative watershed management planning.
GPNMB expression associates with inferior prognosis in patients with small cell lung cancer
Authors: Liu Qian , Zhang Jun , Hu Pengchao , Lohinai Zoltan , Mao Shiqi , Yang Shuo , Dong Youhong , Sun Daoyuan , Ren Shengxiang , Hirsch Fred R. 
Published: December 2022

Abstract
Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which contribute to it as a recalcitrant malignancy. Previously, we found 4 significantly top up-regulated genes in lymph node (LN) metastases tissue when compared with primary tumor by HTG Edge-seq. Among them, Glycoprotein non-metastatic melanoma protein B (GPNMB) was highly expressed in the metastatic lymph node in SCLC. The aim of this study was to investigate the prognostic value and cellular functions of GPNMB in SCLC. Plasma concentration of GPNMB was performed by enzyme-linked immunosorbent assay (ELISA). Clinical characteristic and Overall survival (OS) based on GPNMB concentration was evaluated. Invasion, migration, proliferation and apoptosis ability of SCLC cells were evaluated using migration, matrigel invasion assays, CCK8 assay and flow cytometry respectively. We found that GPNMB was significantly up-regulated in LN than primary SCLC lesions by HTG Edge-seq. 88 patients with SCLC were included in this study. Plasma GPNMB concentration was significantly higher in patients with extensive disease than local disease (P = 0.043). Baseline plasma GPNMB expression was higher in liver metastasis when compared with non-liver metastasis (P = 0.0148), bone metastasis (P = 0.031), brain metastasis (P = 0.035) and non-organ metastasis (P = 0.0045). Patients with high baseline plasma GPNMB had shorter overall survival (OS) (10.32 vs. 16.10 months, P = 0.0299). Importantly, both univariate and multivariate analyses indicated GPNMB higher expression was an independent biomarker for OS (P = 0.040, HR = 0.444). We also found that inhibit GPNMB expression by siRNA significantly suppressed SCLC metastatic and proliferation ability whereas increased apoptosis ability and caused a significant downregulation of vimentin and upregulation of E-cadherin. Our results suggest that expression of GPNMB is associated with metastasis and poor prognosis, and might be served as a novel potential therapeutic target in SCLC.
Can Apparent Diffusion Coefficient (ADC) maps replace Diffusion Tensor Imaging (DTI) maps to predict the volumetric response of meningiomas to Gamma Knife Radiosurgery?
Authors: Speckter Herwin , Palque-Santos Sarai , Mota-Gonzalez Ruben , Bido Jose , Hernandez Giancarlo , Rivera Diones , Suazo Luis , Valenzuela Santiago , Gonzalez-Curi Maria , Stoeter Peter 
Published: December 2022

Abstract
Purpose
Noninvasive methods are desired to predict the treatment response to Stereotactic Radiosurgery (SRS) to improve individual tumor management. In a previous study, we demonstrated that Diffusion Tensor Imaging (DTI)-derived parameter maps significantly correlate to SRS response. This study aimed to analyze and compare the predictive value of intratumoral ADC and DTI parameters in patients with meningiomas undergoing radiosurgery.
Methods
MR images of 70 patients treated with Gamma Knife SRS for WHO grade I meningiomas were retrospectively reviewed. MR acquisition included pre- and post-treatment DWI and DTI sequences, and subtractions were calculated to assess for radiation-induced changes in the parameter values.
Results
After a mean follow-up period (FUP) of 52.7 months, 69 of 70 meningiomas were controlled, with a mean volume reduction of 34.9%. Whereas fractional anisotropy (FA) values of the initial exam showed the highest correlation to tumor volume change at the last FU (CC=-0.607), followed by the differences between first and second FU values of FA (CC=-0.404) and the first longitudinal diffusivity (LD) value (CC=-0.375), the correlation coefficients of all ADC values were comparably low. Nevertheless, all these correlations, except for ADC measured at the first follow-up, reached significance.
Conclusion
For the first time, the prognostic value of ADC maps measured in meningiomas before and at first follow-up after Gamma Knife SRS, was compared to simultaneously acquired DTI parameter maps. Quantities assessed from ADC maps present significant correlations to the volumetric meningioma response but are less effective than correlations with DTI parameters.
Effect of palladium and its nanogeometry on the redox electrochemistry of tetracyanoquinodimethane modified electrode; Application in electrochemical sensing of ascorbic acid
Authors: Maurya Kuldeep Kumar , Singh Kulveer , Malviya Manisha 
Published: December 2022

Abstract
The current finding report the effect of palladium nanoparticles and their nanogeometry on the redox electrochemistry of tetracyanoquinodimethane (TCNQ) modified electrode. Palladium nanoparticles are made in the presence of two different concentrations of 3-aminopropyltrimethoxysilane followed by calcination at 6000C to yield PdNP-1 and PdNP-2 of the average size of 1 µM size and 12 nm, respectively, and are characterized by TEM and XRD. Three types of TCNQ-modified electrodes, namely: (i) TCNQ-1, (ii) TCNQ-2, and TCNQ-3 made with TCNQ alone, TCNQ and PdNP-1; TCNQ with PdNP-2 to understand the dependence of redox electrochemistry of TCNQ on palladium and its nanogeometry. The redox electrochemistry of TCNQ-1, TCNQ-2, and TCNQ-3 with major findings: (a) the difference in anodic (Epa) and cathodic (Epc) peak potentials decrease from 243 mV to 231 mV; (b) increase in anodic peak current from 9.6 µA to 30 µA under similar conditions; (c) the current function gradually increases from 15 to 29 µA/(mV)0.5; (d) charge transfer resistance decreases from 150 k to 22.1 k; (e) the catalytic current increases from 3.18 to 9.28 µA under similar conditions and (f) sensitivity of electroanalysis under similar condition increases from 5 to 15 µA/mM; are recorded justifying the introduction of electrocatalysis along with mediated electrochemistry. In order to support these assertions, the data from cyclic voltammetry, differential pulse voltammetry, impedance spectroscopy, and amperometry are presented here.
Oxidation-induced nanolite crystallization triggered the 2021 phreatomagmatic eruption of Fukutoku-Oka-no-Ba, Japan
Authors: Yoshida Kenta , Miyake Akira , Okumura Shota H. , Ishibashi Hidemi , Okumura Satoshi , Okamoto Atsushi , Niwa Yasuhiro , Kimura Masao , Sato Tomoki , Tamura Yoshihiko , Ono Shigeaki 
Published: December 2022

Abstract
Nanometer-sized crystals (nanolites) play an important role in controlling eruptions by affecting the viscosity of magmas and inducing bubble nucleation. We present detailed microscopic and nanoscopic petrographic analyses of nanolite-bearing and nanolite-free pumice from the 2021 eruption of Fukutoku-Oka-no-Ba, Japan. The nanolite mineral assemblage includes biotite, which is absent from the phenocryst mineral assemblage, and magnetite and clinopyroxene, which are observed as phenocrysts. The boundary between the nanolite-bearing brown glass and nanolite-free colorless glass is either sharp or gradational, and the sharp boundaries also appear sharp under the transmitted electron microscope. X-ray absorption fine structure (XAFS) analysis of the volcanic glass revealed that the nanolite-free colorless glass records an oxygen fugacity of QFM + 0.98 (log units), whereas the nanolite-bearing brown glass records a higher oxygen fugacity (~ QFM + 2). Thermodynamic modelling using MELTS indicates that higher oxygen fugacities increase the liquidus temperature and thus induced the crystallization of magnetite nanolites. The hydrous nanolite mineral assemblage and glass oxygen fugacity estimates suggest that an oxidizing fluid supplied by a hot mafic magma induced nanolite crystallization in the magma reservoir. The oxidation-induced nanolite crystallization then enhanced heterogeneous bubble nucleation, resulting in convection in the magma reservoir and triggering the eruption.
Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus
Authors: Tokunaga Kengo , Nakamura Hidehiro , Toue Sakino , Kato Yumiko , Ida Yosuke , Miyoshi Sawako , Yoneyama Rika , Ohnishi Hiroaki , Hisamatsu Tadakazu , Okamoto Susumu 
Published: December 2022

Abstract
To prevent the progression of type 2 diabetes mellitus (T2DM), early detection and intervention are important. Several studies have already shown that the serum adiponectin level could be useful for evaluating the future risk of T2DM. Recently, plasma free amino acid (PFAA) concentrations havealso emerged as potential biomarkers that predict the future onset of T2DM. In this study, we aimed to further characterise PFAA profiles by elucidating the association with the serum adiponectin level in this cross-sectional study. A total of 1,000 Japanese subjects who underwent medical check-upswere enrolled, and their plasma concentrations of 21 amino acids and clinical parameters were measured. The subjects without T2DM were divided into quartiles (Q1-4) by serum adiponectin level, andthe association between PFAA concentrations and the serum adiponectin level was analysed. Concentrations of glutamate, alanine, proline, tyrosine, histidine, methionine, lysine, branched-chain amino acids (BCAAs) and tryptophan varied significantly according to the adiponectin quartile. Furthermore, serum adiponectin levels showed significant inverse correlations with these amino acids. The change in the PFAA profile in the group with the lowest adiponectin concentrations (Q1) was similar to that of T2DM patients. Although both adiponectin levels and PFAA concentrations are known to be altered by the accumulation of visceral fat and insulin resistance, the levels of glutamate, BCAA, lysine and tryptophan remain significantly associated with adiponectin level after adjustment for age, body mass index and homeostasis model assessment of insulin resistance, showing the direct association between PFAA concentrations and the serum adiponectin level.
Massively recruited sTLR9+ neutrophils in rapidly formed nodules at the site of tumor cell inoculation and their contribution to a pro-tumor microenvironment
Authors: Wang Liying , Kou Mengyuan , Lu Wenting , Zhu Mengru , Qu Kuo , Yu Yongli 
Published: December 2022

AbstractNeutrophils exert either pro- or anti-tumor activities. However, few studies have focused on neutrophils at the tumor initiation stage. In this study, we unexpectedly found a subcutaneous nodule in the groin areas of mice inoculated with tumor cells. The nodule was developed 24 h after the inoculation, filled with tumor cells and massively recruited neutrophils, being designated as neutrophil-infiltrated nodules (NINs). 22% of the neutrophils in NINs are surface TLR9 (sTLR9) expressing neutrophils (sTLR9+neutrophils). With tumor progression, sTLR9+neutrophils were sustainably increased in NINs/tumor tissues, reaching to 90.8% on day 13 after inoculation, with increased expression of IL-10 and decreased or no expression of TNFα.In vivoadministration of CpG 5805 significantly reduced sTLR9 expression of the sTLR9+neutrophils. The reduction of sTLR9 on neutrophils in NINs contributed to the induction of an anti-tumor microenvironment conductive to the inhibition of tumor growth. Overall, the study provides insights for understanding the role of sTLR9+neutrophils in the tumor development, especially in the early stages.