bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonhomogeneous multiparameter problems in Orlicz–Sobolev spaces
Authors: Rădulescu Vicenţiu D. , dos Santos Gelson C. G. , Tavares Leandro S. 
Published: April 2023

AbstractThis paper is concerned with the existence and multiplicity of solutions for a class of problems involving the Φ‐Laplacian operator with general assumptions on the nonlinearities, which include both semipositone cases and critical concave convex problems. The research is based on the subsupersolution technique combined with a truncation argument and an application of the Mountain Pass Theorem. The results in this paper improve and complement some recent contributions to this field.
Do non‐controlling large shareholders affect corporate over‐financialization?: A shareholder hybrid perspective
Authors: Li Bingxiang , Zhang Dan 
Published: April 2023

AbstractThis study investigates the monitoring role of non‐controlling large shareholders (NCLS) on firms' over‐financialization. We compared over‐financialized firms with NCLS with those without. Our first finding suggests that firms with NCLS have a lower extent of over‐financialization. We also find that the hybridity between controlling shareholders and NCLS in a firm decreases over‐financialization. Additional analyses show that NCLS monitor over‐financialization by alleviating corporate myopia. Furthermore, our results reveal that over‐financialization decreases with the relative strength of NCLS compared to controlling shareholders, NCLS' number, and NCLS' shareholdings. Our conclusions remain valid after accounting for endogeneity and employing measures of over‐financialization.
Pushing the limits of low‐cost ultra‐low‐field MRI by dual‐acquisition deep learning 3D superresolution
Authors: Lau Vick , Xiao Linfang , Zhao Yujiao , Su Shi , Ding Ye , Man Christopher , Wang Xunda , Tsang Anderson , Cao Peng , Lau Gary K. K. , Leung Gilberto K. K. , Leong Alex T. L. , Wu Ed X. 
Published: April 2023

PurposeRecent development of ultra‐low‐field (ULF) MRI presents opportunities for low‐power, shielding‐free, and portable clinical applications at a fraction of the cost. However, its performance remains limited by poor image quality. Here, a computational approach is formulated to advance ULF MR brain imaging through deep learning of large‐scale publicly available 3T brain data.MethodsA dual‐acquisition 3D superresolution model is developed for ULF brain MRI at 0.055 T. It consists of deep cross‐scale feature extraction, attentional fusion of two acquisitions, and reconstruction. Models for T1‐weighted and T2‐weighted imaging were trained with 3D ULF image data sets synthesized from the high‐resolution 3T brain data from the Human Connectome Project. They were applied to 0.055T brain MRI with two repetitions and isotropic 3‐mm acquisition resolution in healthy volunteers, young and old, as well as patients.ResultsThe proposed approach significantly enhanced image spatial resolution and suppressed noise/artifacts. It yielded high 3D image quality at 0.055 T for the two most common neuroimaging protocols with isotropic 1.5‐mm synthetic resolution and total scan time under 20 min. Fine anatomical details were restored with intrasubject reproducibility, intercontrast consistency, and confirmed by 3T MRI.ConclusionThe proposed dual‐acquisition 3D superresolution approach advances ULF MRI for quality brain imaging through deep learning of high‐field brain data. Such strategy can empower ULF MRI for low‐cost brain imaging, especially in point‐of‐care scenarios or/and in low‐income and mid‐income countries.
Anxiety and depression among patients attending a multidisciplinary foot clinic
Authors: Almaqhawi Abdullah , Morrison Amy E , Berrington Rachel , Kong Marie‐France 
Published: April 2023

AbstractAim: Diabetic foot ulcers (DFUs) are linked to morbidity, decreased mobility, and feelings of isolation, powerlessness and sadness. The aim of our study was to explore the prevalence of anxiety and depression symptoms in adult patients with DFU.Method: We analysed questionnaires completed by patients with DFU attending our University Hospital Multidisciplinary Foot Clinic service over a one‐month period in March 2022. The patients had completed three questionnaires, comprising of questions relating to socio‐demographic status and care perceptions, the Patient Health Questionnaire‐9 (PHQ‐9) scale to assess depression, and the Generalized Anxiety Disorder scale (GAD‐7) to assess anxiety.Results: Of the 60 patients who completed the questionnaires, 35% (n=21) reported anxiety symptoms and 40% (n=24), depressive symptoms. Individuals with comorbidities were three times more likely to report depression relative to those without any comorbidities (OR 3.3; 95% CI 1.13–12.56). Younger individuals (less than 50 years), were almost nine times more likely to report anxiety in comparison to those aged 60 years or more (adjusted OR 8.9; 95% CI 1.01–86.41), despite adjustment for confounding variables.Conclusion: The prevalence of depression and anxiety in this cohort of patients with DFU was low, but those who were affected reported moderate to severe symptoms. Younger individuals and those with comorbid conditions with DFU are more likely to experience an adverse impact on their mental health. This is a crucial factor to consider in the management of people undergoing DFU care. Strategies to reduce anxiety and/or depressive symptoms could impact both quality of life and wound healing. Copyright © 2023 John Wiley & Sons.
Rescheduling gabapentinoids had negligible effects on prescribing behaviour by general practitioners in England
Authors: Kamerman Peter 
Published: April 2023

AbstractPurposeTo determine whether the rescheduling of gabapentinoids in England as Schedule 3 Controlled Substances in April 2019, changed prescribing behaviour for gabapentinoids by general practitioners.MethodsData on the monthly number of prescription items and the monthly average dose per prescription item were analysed for the period April 2017 to April 2021 under three models: (i) a simple linear regression, (ii) a linear spline with a knot at April 2019, and (iii) a parallel slopes model with time before and after the rescheduling as a covariate. Best fit models were selected based on them having the lowest corrected Akaike's information criterion. Auto‐regressive integrated moving average (ARIMA) models were also generated.ResultsFor gabapentin, the best fit model for the number of prescription items was the simple linear model, and for the dose per prescription item it was the parallel slopes model. For pregabalin, the best fit model was the linear spline for the number of prescription items and the dose per prescription item. For all models, the interval estimates for the slopes were consistent with no change or no meaningful change in prescribing behaviour after April 2019. Forecasts from ARIMA models for gabapentin and pregabalin were consistent with no change in the number of prescription items per month. However, forecasts for the dose per prescription item for gabapentin or pregabalin did not fully capture the post‐April 2019 trajectories.ConclusionThe reclassification of gabapentinoids did not materially change the prescribing behaviour of these drugs by general practitioners in England.
First‐principles study on the CH4 adsorption performance of Mn‐modified N‐doped graphdiyne
Authors: Chen Zhiwei , Zhao Qiuyu , Chen Yuhong , Sun Jialin , Zhang Meiling , Sang Cuicui , Zhang Cairong 
Published: April 2023

AbstractNGDY has high‐N atom doping rate, many active sites, large pore size, outstanding thermal stability, and excellent lithium‐ion storage properties. The mixed adsorption of the Mn‐modified NGDY (Mn‐NGDY) system has been studied with the first principles approach, which shows the effects and the mechanism of action about the modified Mn atom and H2 molecules on the adsorption of CH4. From the results, more electrons are transferred from the Mn atom to the neighboring six‐membered ring, making the Mn atom positively charged and forming a strong Coulomb interaction with the substrate. There is Coulomb interaction between the first two methane molecules and Mn atoms, and CH4 molecules have strong polarization phenomenon under this interaction, which causes the surrounding CH4 molecules of the first layer (The CH4 molecules around the first two CH4 molecules) inducing polarization along the XY plane (parallel substrate), and the surrounding CH4 molecules of the second layer inducing polarization along the Z‐axis direction, which improve the adsorption properties of other CH4 molecules. In the first layer, the interaction forces of the adsorbed CH4 molecules region mainly come from the interaction forces between CH4 and the substrate, and the interaction forces between CH4 molecules dominate in the adsorption of second layer. Polarization of H2 molecules along the Z‐axis direction causes the formation of a weak negative center above it, which promotes the adsorption of CH4 molecules above it. For the 2Mn‐NGDY system, a maximum of 72 CH4 molecules and 4 H2 molecules can be adsorbed simultaneously on both sides, when the average adsorption energy and adsorption amount reach −0.169 eV and 73.41 wt%.
Resilient time‐varying formation tracking for mobile robot networks under deception attacks on positioning
Authors: Liu Yen‐Chen , Liu Kai‐Yuan , Song Zhuoyuan 
Published: April 2023

AbstractThis paper investigates the resilient control, analysis, recovery, and operation of mobile robot networks in time‐varying formation tracking under deception attacks on global positioning. Local and global tracking control algorithms are presented to ensure redundancy of the mobile robot network and to retain the desired functionality for better resilience. Lyapunov stability analysis is utilized to show the boundedness of the formation tracking error and the stability of the network under various attack modes. A performance index is designed to compare the efficiency of the proposed formation tracking algorithms in situations with or without positioning attacks. Subsequently, a communication‐free decentralized cooperative localization approach based on extended information filters is presented for positioning estimate recovery where the identification of positioning attacks is based on Kullback–Leibler divergence. A gain‐tuning resilient operation is proposed to strategically synthesize formation control and cooperative localization for accurate and rapid system recovery from positioning attacks. The proposed methods are tested using both numerical simulation and experimental validation with a team of quadrotors.
Exploration of HPTLC Technology for Rapid Chemical Fingerprinting and Simultaneous Determination of Bioactive Constituents from Clitoria ternatea Linn.
Authors: Makasana Jayanti , Gajbhiye Narendra , Kumar Bishoyi Ashok , Savaliya Mehulkumar , Raju Saravanan , Bansod Shrikant , Baldaniya Lalji , Dholakiya Bharatkumar 
Published: April 2023

AbstractThe analytical methods used for herbal analysis are need to be economic, fast and also produce minimum quantities of hazardous chemical waste. Presently analytical community put interest in the research area of non‐hazardous and eco‐friendly practices to develop various green chromatographic methods for routine quality analysis. High cost of phytochemical analysis and uses of hazardous chemicals with high‐end sophisticated instrument, the attempt made to develop a simple analytical method for multiple samples with short time and less uses of solvents. A HPTLC method was developed for simultaneous determination of biological important constituents like β‐sitosterol, taraxerol, clitorienolactone B and β‐sitosterol glycoside from Clitoria ternatea Linn. The proposed method was validated and satisfied the ICH guidelines to demonstrate that the method is adaptable for its intended purpose. The method is simple, sensitive and economic it therefore embraces potential for detection, monitoring, and simultaneous quantification of the four bioactive compounds for C. ternatea and could also be apply to other species.
Stannous Chloride Redefined: A Mild and an Efficient Catalyst System for Poly(butylene succinate) (PBS) Synthesis
Authors: Savitha K. S. , Senthil Kumar M. , Jagadish R. L. 
Published: April 2023

AbstractThe efficiency of stannous chloride as a mild and efficient catalyst system towards PBS synthesis is described in detail. A plausible mechanism has also been proposed for the synthesis of medium to high molecular weight PBS.
Copper (I) Catalysed Tandem C−C and C−N Bond Cleavage of N‐Fused Imidazoles towards the Synthesis of N‐pyridinylamides
Authors: Ahmad Sofi Firdoos , Masoodi Mubashir H. , Ovais Dar Mohammad , Bharatam Prasad V. 
Published: April 2023

AbstractCopper(I) catalysed oxidative conversion of imidazopyridines into N‐pyridinylamides has been achieved via tandem C−C and C−N bond cleavages under oxidative reaction conditions. The methodology has wide substrate scope and products were formed in good to excellent yields. This method is suitable for the oxidative conversion of both C‐3 functionalized as well as non‐functionalized imidazopyridines
Enhanced Activity of Cerium‐Doped Co−Cr−O Composite Catalyst in Selective Catalytic Reduction of NO with NH3
Authors: Jin Leying , Li Haixia , Zhang Yun , Peng Dan , Sun Zhijun , Zhang Anchao 
Published: April 2023

AbstractCobalt‐chromium oxide catalyst and cerium‐doped cobalt‐chromium oxide catalyst were prepared by the coprecipitation method. The doping effect of Ce on the catalyst for selective catalytic reduction of NO with NH3 was investigated. Compared to Cobalt‐chromium oxide catalyst, the doping of Ce improved the catalytic activity and water and sulfur resistance of the catalyst. The doping of Ce significantly changed the surface morphology, reduced the crystallinity and increased the specific surface area of the catalyst. The large specific surface area of the catalyst facilitated the high dispersion of the acidic sites and promoted the adsorption and desorption of NH3. The doping of Ce increased the chemisorbed oxygen content and the number of acidic sites, enhancing the SCR activity of the catalyst. In addition, the doping of Ce increased the percentage of Co3+ and changed the ionic state of Cr, promoting the interaction between metal ions.
Green Synthesis of TiO2 Nanoparticles in a Deep Eutectic Solvent for High‐Performance Photocatalysis: The Role of the Cosolvent
Authors: Guzmán‐Cruz Andrés , Lourdes Ruiz‐Peralta Ma. , Pal Umapada , Paraguay‐Delgado F. , Pal Mou 
Published: April 2023

AbstractHerein, we report a unique surfactant‐free synthetic pathway for the synthesis of anatase TiO2 catalysts in the size range of 13 to 20 nm by solvothermal method using choline chloride‐urea deep eutectic solvent (DES) as green media and 2‐propanol as cosolvent. The composition of reline was tuned by adding 0 (pure reline), 5, 10, 20 and 50 wt% of 2‐propanol. The amount of cosolvent was found to have a significant influence on TiO2 particle size, N2 isotherms and the magnitude of Urbach energy formed within the band gap of mesoporous TiO2 nanostructures. The sample obtained with 10 wt% of propanol showed the best photocatalytic activity in the degradation of Rhodamine B (RhB), which is attributed to the combined effect of Urbach tail states, specific surface area, particle size and band gap energy of TiO2 NPs. Radical trapping experiments with scavengers revealed that OH⋅ radicals are primarily responsible for RhB decomposition.
Synthesis, Characterization, Bioactivity Impacts of New Anthranilic Acid Hydrazones Containing Aryl Sulfonate Moiety as Fenamate Isosteres
Authors: Tokalı Feyzi Sinan , Taslimi Parham , Sadeghian Nastaran , Taskin‐Tok Tugba , Gülçin İlhami 
Published: April 2023

AbstractIn this study, it was planned to synthesize new members of fenamate isosteres and investigate its effect on some metabolic enzymes such as Acetylcholinesterase, Butyrylcholinesterase, α‐Glucosidase, Carbonic andyhrase I–II. The target compounds were obtained from the reaction of N‐subtituted anthranilic hydrazides with sulfonylated aldehyde derivatives. The structures of the compounds were characterized using Fourier‐transform Infrared, Nuclear Magnetic Resonance, and High‐resolution Mass Spectroscopy. Compounds had potent inhibitory strength with Ki values in the range of 0.23±0.03–7.12±0.41 μM against carbonic anhydrase‐I and 0.13±0.01–6.21±0.52 μM against carbonic anhydrase‐II. Compounds inhibited acetycholinesterase and butyrylcholinesterase with the Ki values in the range of 42.73±15.80 nM–977.52±32.67 nM and 25.84±4.09 nM–261.36±34.05 nM, respectively. All compounds showed potent inhibitory activity against α‐glucosidase enzyme with IC50 value 1.51–23.51 nM, compared to the standard acarbose (64.53 nM). The orientation of binding of the synthesized compounds were further appraised by molecular docking studies, which reflects the importance of sulfonyl, furan, thiophene, and methoxy groups in protein‐ligand interaction. The docking results are complementary with the Ki values of compounds while the interaction pattern of the current compounds clearly indicates their structure‐activity relationship.
Renewable synthesis of novel acrylates from biomass‐derived 5‐substituted‐2‐furaldehydes by Morita‐Baylis‐Hillman reaction
Authors: Anchan Harshitha N. , Dutta Saikat 
Published: April 2023

AbstractBiomass‐derived furfurals are becoming increasingly popular as renewable chemical building blocks for synthesizing specialty chemicals. Morita‐Baylis‐Hillman (MBH) reaction is a classic carbon‐carbon bond‐forming transformation between the α‐position of an activated alkene and a carbon electrophile (e. g., aldehyde) using a nucleophilic catalyst, such as a tertiary amine or phosphine. The MBH reaction is highly atom economical, affords excellent yields of adducts under mild reaction conditions, introduces substantial molecular complexity, and enjoys broad substrate scope. In this work, several novel MBH adducts have been synthesized starting from biomass‐derived 5‐substituted‐2‐furaldehydes and acrylates using 1,4‐diazabicyclo[2.2.2]octane (DABCO) as the organocatalyst. This work reports the first systematic study of the MBH reaction of 5‐substituted‐2‐furaldehydes and acrylates. A general synthetic protocol for the high‐yielding synthesis of MBH adducts has been developed. The reactions were performed at room temperature under solvent‐free conditions, and the spectroscopically pure products were produced in good to excellent isolated yields. Moreover, DABCO was recovered from the reaction mixture and successfully recycled.
Total Synthesis of Okaspirodiol
Authors: Madasu Madhu , Mohapatra Debendra K. 
Published: April 2023

AbstractThe asymmetric total synthesis of okaspirodiol was achieved following Sharpless asymmetric epoxidation, Gilman reaction, Wittig reaction, Horner–Wadsworth–Emmons olefination, and coupling of alkyne with the aldehyde, and acid‐catalyzed spiroketalization as key reactions.
Bis 1, 2, 3‐ Triazoles Linked Deoxybenzoin Hybrids as Antimicrobial Agents: Synthesis, In Vitro and In Silico Screening
Authors: Aitha Shalini , Thumma Vishnu , Ambala Shankaraiah , Matta Raghavender , Panga Shyam , Pochampally Jalapathi 
Published: April 2023

AbstractA series of new deoxybenzoin based bis 1,2,3‐triazole analogues were synthesized and reported in the present communication. Synthesis of analogues were accomplished by a convenient 3 step protocol incorporating Friedel craft acetylation, propargylation and copper‐catalyzed click chemistry in final step to afford 1,2,3‐triazole moiety. The title compounds were screened for antimicrobial activity against two gram positive bacteria viz. S. aureus, B. cereus and two gram negative bacteria viz. E. coli, P. aeruginosa, and three fungus viz. C. albicans, A. niger, A. flavus strains. Compound containing 4‐fluoro substitution (7a) showed slightly superior in‐vitro antimicrobial activity than reference drugs Ciprofloxacin and Fluconazole. SAR of developed hybrids with reference to antimicrobial activity was predicted and presented. In‐silico bioactivity is investigated by molecular docking studies against the crystal structures of glucosamine‐6‐phospate synthase (PDB ID: 2VF5) and secreted aspartic proteinase (PDB ID: 2QZW) which endorsed good binding interactions.
Anti‐proliferative and Apoptotic Effects of Coordination Compounds of Zinc(II), Palladium(II), and Platinum(II) with Tridentate 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine
Authors: Pekdemir Fatih , Sengul Abdurrahman , Akgun Oguzhan , Ari Ferda , Acar‐Selcuki Nursel 
Published: April 2023

AbstractThe mononuclear coordination compounds, [Zn(L)Cl2] (1), [Pd(L)Cl]Cl (2), and [Pt(L)Cl]Cl (3) (L) is a tridentate‐coordinated of 4‐(6‐hydroxyphenyl)‐2,6‐di(thiazol‐2‐yl)pyridine) were synthesized and characterized by different spectroscopic methods (FTIR, MALDI‐TOF‐MS, 1H NMR, 13C NMR, and UV/Vis). By using density functional theory (DFT) and time‐dependent DFT (TD‐DFT) methods, the geometrical parameters, UV/Vis absorption spectra, and infrared vibrational frequencies for the investigated compounds were explored. Anticancer activities of these compounds were determined by SRB viability assay in human lung (A549 and H1299), prostate (LNCAP), colorectal (HT‐29), breast cancer (MDA‐MB‐231) and healthy bronchial (BEAS‐2B), breast (MCF‐10A), colon (CCD‐18Co), and prostate (WPMY‐1) epithelial cells. Caspase 3/7 activity, cleaved cytokeratin‐18, and PARP levels were measured to determine apoptosis in the metal compounds found to be effective. Among the compounds, 1 showed a selective inhibiting effect and induced apoptosis on the cancer cells, thus further analyses are needed to evaluate its antitumor/anticancer activity.
Chemically Amplified Multiplex Detection of SARS‐CoV‐2 and Influenza A and B Viruses via Paint‐Programmed Lateral Flow Assays
Authors: Lee Dohwan , Ozkaya‐Ahmadov Tevhide , Sarioglu A. Fatih 
Published: April 2023

AbstractSevere acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) continues to threaten lives by evolving into new variants with greater transmissibility. Although lateral flow assays (LFAs) are widely used to self‐test for coronavirus disease 2019 (COVID‐19), these tests suffer from low sensitivity leading to a high rate of false negative results. In this work, a multiplexed lateral flow assay is reported for the detection of SARS‐CoV‐2 and influenza A and B viruses in human saliva with a built‐in chemical amplification of the colorimetric signal for enhanced sensitivity. To automate the amplification process, the paper‐based device is integrated with an imprinted flow controller, which coordinates the routing of different reagents and ensures their sequential and timely delivery to run an optimal amplification reaction. Using the assay, SARS‐CoV‐2 and influenza A and B viruses can be detected with ≈25x higher sensitivity than commercial LFAs, and the device can detect SARS‐CoV‐2‐positive patient saliva samples missed by commercial LFAs. The technology provides an effective and practical solution to enhance the performance of conventional LFAs and will enable sensitive self‐testing to prevent virus transmission and future outbreaks of new variants.