bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis and cerebral microbleeds
Authors: Zhihui Yu , Jun Ma , Ke Shen , Jianguang Chen 
Published: April 2023

Abstract
Background: Intracranial atherosclerotic stenosis (ICAS) is one of the important causes of occurrence and recurrence of ischemic stroke worldwide. Combined antiplatelet therapy may increase the risk of intracerebral hemorrhage, especially in patients with intracerebral microhemorrhage,Objective The aim of this study is to investigate the safety of dual antiplatelet drugs in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) and cerebral microbleeds(CMBs).
Methods and Results: 305 patients with sICAS were divided into two groups: 215 patients without CMBs and 90 patients with CMBs. All patients were treated with dual antibody therapy for 3 months according to the existing treatment, and were followed up for half a year. The NIHSS and modified Rankin score (mRS) before and after treatment were compared between the two groups, and the incidence of adverse reactions and bleeding conversion were observed. At the same time, the two groups were compared. Moderate to severe CMBs (>6) increased the risk of bleeding in sICAS.
Conclusion For patients with sICAS, it is necessary to conduct head MRI SWI sequence examination to screen out high load CMBs.
Extreme Partitioning of Relic and Contemporary Waters in Arid Environments
Authors: Moran Brendan , Boutt David , Munk LeeAnn , Fisher Joshua 
Published: April 2023

Abstract
Deciphering the dominant controls on groundwater-surface water-climate connections is critical to understanding water cycles in arid environments, yet persistent uncertainties remain. The growing demand for critical minerals such as lithium and associated water demands has amplified the urgency to address these unknowns. We present an integrated hydrological analysis of the Dry Andes utilizing a uniquely large and comprehensive set of tracer data (3H, 18O/2H) and physical observations. We find two strongly decoupled hydrological systems which interact only under specific hydrogeological conditions where preferential conduits have developed. These conduits which efficiently transport contemporary water (wks to yrs old) in the system control the interplay between modern hydroclimate variations and groundwater aquifers. Contemporary waters account for a small portion of basin budgets but are critical to sustaining surface waters, as a result, these systems are sensitive to short-term climate and anthropogenic perturbations. This framework describes a new understanding of dominant controls on natural water cycles intrinsic to these arid mountain systems.
Formation mechanisms, interrelationships, and effects of cognitive factors on diet and physical activity during the post-bariatric surgery period: a cross-sectional study based on compensatory carry-over action model
Authors: Zhao Kang , Zhu Hanfei , Huang Lidong , Yang Ningli , Othman Saleh Mohammed Alhaj , Shi Wenbing , Hua Hongxia , Liang Hui , Xu Qin 
Published: April 2023

Abstract

Background Diet and physical activity (PA) are the two most important behaviors to control energy balance after bariatric surgery, post-bariatric patients need dual behavioral management, and these behaviors are jointly affected by various cognitive factors. This study applied compensatory carry-over action model (CCAM) to investigate the effects of cognitive factors on behaviors, and the effects of behaviors on subjective health outcomes.
Methods This cross-sectional study was conducted among patients at the third month after bariatric surgery in China. We collected patients’ data of status of diet and PA, behavioral cognitive factors (intention, self-efficacy, compensatory belief, transfer cognition), and subjective health outcomes (perceived stress, well-being, quality of life). Structural equation model (SEM) were established to test the hypotheses in CCAM and the mediation relationships.
Results A total of 239 patients data were collected. The results of SEM analysis showed: (1) Among the antecedent cognitive factors, only compensatory belief had a significant effect on diet (P<0.001). (2) Both intention and self-efficacy formed direct associations with their corresponding behaviors, compensatory belief exerted significant effects on intention, transfer cognition exerted significant effects on self-efficacy(P<0.05), which were consistent with the original hypotheses in CCAM. (3) PA demonstrated significant influence only on perceived stress (P=0.004), diet demonstrated significant effects on all subjective health outcomes (P<0.05). (4) The results of mediation analysis showed intention exerted partial mediating effects on the relationship between compensatory belief and diet and exerted complete mediating effects on the relationship between compensatory belief and PA, self-efficacy exerted complete mediating effects on the relationship between transfer cognition and diet and between transfer cognition and PA.
Conclusion Among the antecedent cognitions, the carry-over effect of transfer cognition did not directly affect the behaviors, and interventions should mainly focus on improventment of diet through inhibition of compensatory belief. The associations between behaviors and subjective health outcomes showed that diet exerted more critical effects on the overall health than PA. Overall, based on the analysis of CCAM and from the perspective of joint promotion of behaviors after bariatric surgery, dietary intervention had a higher priority than PA intervention.
Correlation analysis of lumbar disc herniation with lumbar lordosis, intervertebral angle and lumbosacral angle in young patients
Authors: Zhan Zihao , Li Ran , Fu Dongming , Han Hao , Meng Bin 
Published: April 2023

Abstract
Background: It is generally believed that lumbar disc herniation is more common in the elderly population. But with the continuous change of life and working style, more and more young people are suffering from lumbar disc herniation due to their long hours at the desk and poor posture.
Purpuse: To analyze the characteristics of lumbar lordosis (LL), intervertebral angle (IVA) and lumbosacral angle (LSA) in young patients with low back pain and their relationship with lumbar disc herniation.
Material and Methods: 148 young patients with low back pain underwent lumbar magnetic resonance (MR) and digital radiography (DR). According to the results, they were divided into non-lumbar disc herniation group (NLDH group) and lumbar disc herniation group (LDH group). LL, IVA and LSA were measured on the lateral plainradiographs. Then we compare and analyze the characteristics of LL, IVA and LSA of the two groups and their relationship with lumbar disc herniation.
Results: In both groups, IVA gradually increased from L1-L2 to L5-S1, and it reached the maximum at L5-S1. IVA of each segment and the mean LL in LDH group were both smaller than those in NLDH group, but the mean LSA was larger in LDH group, and the differences were all statistically significant (P<0.05). Lumbar disc herniation was negatively correlated with IVA from L1-L2 to L5-S1 and LL, but positively correlated with LSA. Young patients with lower LL and IVA and higher LSA are more likely to develop lumbar disc herniation.
Conclusion: LL, IVA and LSA measured on the lateral plain radiographs can be used as important reference indexes to reflect the condition of lumbar disc herniation.
Position Dependent Formula for the Effect of Opening in Infilled Frame
Authors: Tabeshpour Mohammad Reza , Arasteh Arash Mahdipour 
Published: April 2023

Abstract
Infills can have both positive and negative effects on structures. If designers neglect infills in their design, they may face problems such as over-designing of the main elements of the structure due to not utilizing the stiffness and strength of infills. Moreover, problems like soft-story or short-columns may occur during an earthquake. There are several equations available for calculating the effects of infill stiffness. This article aims to calculate the reduction factor in stiffness when there is an opening in the infill. Furthermore, the present paper considers various parameters that can affect the reduction factor, which have not been addressed by many researchers. These parameters include the location, area, width, and height of the opening, as well as the frame section. For this reason, over 500 different models were analyzed, each varying in at least one parameter from the others. Based on these models, a new formula for calculating the reduction factor of stiffness in perforated infills is introduced. This new formula is more precise and comprehensive than the previous formulas.
Impact of urban‒rural medical insurance integration on the health of the elderly: Evidence from China
Authors: Zhao Jianguo , Liu Ziqiong 
Published: April 2023

Abstract
Background
As the aging population continues to grow at an accelerating pace, it is crucial to pay attention to the impact of public medical insurance policies on the health of older adults. Therefore, based on the health status of older adults in China, we aim to evaluate the effectiveness of the implementation of the integrated policy of urban and rural medical insurance in China.
Methods
Data were obtained from China Health and Retirement Longitudinal Study (CHARLS) of 2015and 2018. we use the difference-in-differences model (DID) to investigate the impact of the urban‒rural medical insurance integration policy on the health status of elderly individuals, we further use Propensity score matching method-difference-in-differences (PSM-DID) and individual fixed effect method to conduct robustness checks on the benchmark regression results.
Results
The results indicate that the urban‒rural medical insurance integration policy effectively improved the health status of elderly individuals. Heterogeneity analysis confirms that the health promotion effect brought about by the urban-rural medical insurance integration policy is more significant among elderly individuals with chronic diseases, higher age and lower education levels. Furthermore, The mechanism test reveals that the implementation of the urban‒rural medical insurance integration policy can effectively improve the medical satisfaction of elderly individuals, which in turn benefits the health of elderly individuals.
Conclusion
The implementation of the integrated policy of urban and rural medical insurance has a significant positive effect on the health status of older adults, particularly for the vulnerable elderly population. This finding indicates that there is still room for further optimization of the current basic medical insurance policies and the level of medical security in China.
Icariside II targets in vitro MAPK and PI3K/Akt signaling in human nasopharyngeal carcinoma cells to induce apoptotic death and suppress proliferation
Authors: XIE Mao , TANG Shengping , LIAO Shijie , LIU Fangxian , WANG Renjun , GUO Zhaoliang , TAN Songhua , TANG Anzhou , LIU Yun , HE Guangyao 
Published: April 2023

Abstract
Background
Icariside II is a derivative of Herba Epimedii, which is a traditional Chinese medicine. While prior reports have demonstrated that this flavonoid exerts a diverse array of antitumor activities when used to treat different human tumor cells, its impact on nasopharyngeal carcinoma (NPC) cells remains to be rigorously investigated.
Methods
In this study, MTT assays and flow cytometry were used to examine the impact of icariside II treatment on the proliferative and apoptotic activity of NPC cells in vitro. In addition, changes in MAPK and PI3K/Akt pathway activation were examined via qPCR and Western immunoblotting.
Results
Together, these analyses suggested that icariside II was able to markedly suppress NPC proliferation in a dose- and time-dependent fashion. Mechanistically, exposure to this flavonoid promoted the apoptotic death of the CNE1 and CNE2 cell lines through the simultaneous downregulation of Bcl-2 and the upregulation of Bax. In addition, icariside II suppress ERK1/2 and Akt phosphorylation while enhancing p38 phosphorylation.
Conclusions
As such, icariside II is capable of inhibiting NPC cell proliferation and inducing apoptotic death at least in part by modulating MAPK and PI3K/Akt signaling.
Traditional pattern enhancement based on improved singular value decomposition and gamma function in the frequency domain
Authors: Dong Yingda , He Chunguang , Yuan Yunmei , yan Yanping , Gao Fan , Wang Ximing , Duo hua 
Published: April 2023

Abstract
Aiming at the problems of blurring and distortion of traditional patterns, an enhancement method to improve resolution and contrast is proposed.First, the discrete wavelet transform, stationary wavelet transform, and interpolation algorithm are used to obtain high-resolution images of traditional patterns. Then, the improved singular value matrix coefficients and the reconstructed gamma function are used to enhance the image contrast to obtain high-resolution and contrast-enhanced patterns. The experimental results show that the evaluation indexes such as mean square error, peak signal-to-noise ratio, and structural similarity corresponding to this method are improved compared with other comparison methods. It can effectively improve the quality of traditional patterns and is of great significance to the research on the restoration and protection of traditional patterns.
Association of lysophosphatidic acid molecules with liver fibrosis – different roles indicated
Authors: Tobita Hiroshi , Sakai Hiromichi , Yamaguchi Akane , Notsu Yoshitomo , Kataoka Masatoshi , Yazaki Tomotaka , Nabika Toru , Ishihara Shunji , Kobayashi Hironori 
Published: April 2023

Abstract

Aim: Lysophosphatidic acid (LPA), which is produced by autotaxin (ATX) known as a marker of liver fibrosis, is a member of the group of lysophospholipids that function as extracellular mediators to activate specific G‐protein‐coupled receptors. This lipid is composed of LPA molecules with varied chemical forms that may have different biological roles. The present cross-sectional study was conducted to investigate the associations of various LPA molecules with liver fibrosis.
Methods: Forty-six patients affected by various types of liver disease, including 16 with non-alcoholic fatty liver disease, who underwent an ultrasound-guided liver biopsy were recruited for this study. Liver fibrosis was evaluated using histological grading, as well as shear wave velocity (Vs) and serum level of type Ⅳcollagen 7S (T4c7s). Serum levels of LPA molecules were determined using liquid-chromatography tandem mass-spectrometry (LC-MSMS), while ATX in serum was measured by use of an immunoassay.
Results: Total LPA showed a significant positive association with fibrosis severity evaluated based on histological grading, Vs, and T4c7s used as parameters, following adjustment for other confounding factors, including disease type, age, gender, body mass index, and high-sensitivity C-reactive protein. This association was replicated when 16:0-LPA was substituted for total LPA. In contrast, when 20:4-LPA was substituted for total LPA, no significant association with liver fibrosis was observed. Additionally, 20:4-LPA did not demonstrate a significant correlation with serum ATX, in contrast to 16:0-LPA as well as total LPA.
Conclusions: Although total LPA concentration was shown to be associated with liver fibrosis, the degree of association varied among the different LPA molecule chemical forms, suggesting different pathophysiological roles of individual LPA molecules. The present findings indicate the importance of analyzing individual LPA molecules for determination of association with liver fibrosis and the usefulness of LC-MSMS for that purpose.
Lessons from two series by physicians and caregivers’ self-reported data, and DNA methylation profile in DDX3X-Related Disorders
Authors: Geneviève David , Ruault Valentin , Burger Pauline , Gradels-Hauguel Johanna , Ruiz-Pallares Nathalie , Association Xtraordinaire , Jamra Rami Abou , Afenjar Alexandra , Alembik Yves , Alessandri Jean-Luc , Stéphanie Arpin , Barcia Giulia , Bendová Šárka , Bruel Ange-Line , Charles Perrine , Chatron Nicolas , Chopra Maya , Conrad Solène , Cormier-Daire Valérie , Cospain Auriane , Coubes Christine , Coursimault Juliette , Delahaye-Duriez Andrée , Doco-Fenzy Martine , Dufour William , Durand Benjamin , ENGEL Camille , Faivre Laurence , Ferroul Fanny , FRADIN Mélanie , Frenkiel Hélène , Fusco Carlo , Garavelli Livia , Garde Aurore , Gérard Bénédicte , Germanaud David , Goujon Louise , Gouronc Aurélie , Ginglinger Emmanuelle , Goldenberg Alice , Hancarova Miroslava , Hancarova Miroslava , Héron Delphine , Isidor Bertrand , Marçais Nolwenn Jean , Keren Boris , Koch-Hogrebe Margarete , Kuentz Paul , Lamure Victoria , Lebre Anne-Sophie , Lecoquierre François , Lehman Natacha , Lesca Gaetan , Lyonnet Stanislas , Martin Delphine , Mignot Cyril , Neuhann Teresa , Nicolas Gaël , Nizon Mathilde , Petit Florence , Philippe Christophe , Piton Amélie , Pollazzon Marzia , Prchalova Darina , Putoux Audrey , RIO Marlène , Rondeau Sophie , Rossi Massimiliano , Sabbagh Quentin , Saugier-Veber Pascale , Schmetz Ariane , Steffann Julie , Thauvin-Robinet Christel , Toutain Annick , Tran-Mau-Them Frédéric , Trimarchi Gabriele , Vincent Marie , Vlckova Marketa , Wieczorek Dagmar , Willems Marjolaine , yauy kevin , Zelinová Michaela , Ziegler Alban , Chaumette Boris , Sadikovic Bekim , Mandel Jean-Louis 
Published: April 2023

Abstract
We report two series of individuals with DDX3X variations, one (48 individuals) from physicians and one (44 individuals) from caregivers. These two series include several symptoms in common, with fairly similar distribution, which suggests that caregivers’ data are close to physicians’ data. For example, both series identified early childhood symptoms that were not previously described: feeding difficulties, mean walking age and age at first words. Each of the two datasets provide complementary knowledge. We confirmed that symptoms are similar to those in the literature and provide more details on feeding difficulties. Caregivers considered that the symptom attention-deficit/hyperactivity disorder was most worrisome. Both series also reported sleep disturbance. Recently, anxiety has been reported in individuals with DDX3X variants. We strongly suggest that attention-deficit/hyperactivity disorder, anxiety and sleep disorders need to be treated. In addition, we demonstrate preliminary evidence of a mild genome-wide DNA methylation profile in patients carrying mutations in DDX3X.
Image restoration technology of Tang Dynasty tomb murals based on adversarial edge learning
Authors: Yan Yao , Zhang Rui , He Hao , Lei Tong , Ma Li , Wang Wei , Jiang Chao 
Published: April 2023

Abstract
Xi'an, China houses a vast collection of valuable Tang dynasty (618AD-907AD) tomb murals that have experienced various degrees of damage over time due to weathering. This research proposes an adversarial edge learning-based mural restoration technique that provides a fast and accurate automatic repair of the murals. The method uses generative adversarial networks to learn how to repair the edge contour of the damaged mural and restore the missing content. The contour restoration network and the mural restoration network are trained and updated simultaneously to enhance the feature extraction and restoration coordination performance of the network. The experiments were conducted on a self-built Tang dynasty tomb mural painting restoration dataset and compared to several existing algorithms. The proposed algorithm showed a 1.3 increase in Peak Signal to Noise Ratio (PSNR) and a 1.43% increase in Structural Similarity (SSIM) value, providing a precise restoration of the structure and contour of the mural content. The algorithm successfully repaired damaged murals with fractures and small parts breaking off. The suggested method can be useful for both the technical repair and conservation of significant national visual cultural property and the digital restoration of historic murals.
Enhancing the nutritional management of boron in oil palm crops through a comprehensive evaluation of its dynamics in different plant organs
Authors: Viégas Ismael de Jesus Matos , Silva Washington Duarte Silva da , Ferreira Eric Victor de Oliveira , Pereira Greice Leal , Costa Milton Garcia , Silva Alasse Oliveira da , Conceição Heráclito Eugênio Oliveira da 
Published: April 2023

Abstract
This study aimed to evaluate the rates of B accumulation, immobilization, recycling, and exportation in oil palm plants at different cultivation ages and in various organs. The study was conducted in oil palm plantations owned by Agropalma S/A in the municipality of Tailândia, Pará State, Brazil. A completely randomized design was used, with four replications and seven treatments, representing plant ages ranging from 2 to 8 years of planting. The dynamics of B were evaluated in different plant organs, including petioles, rachis, leaflets, cabbage (palm heart), stipe, peduncles, arrows, male inflorescences, spikelets, and fruits. The findings showed that cabbage had the highest B concentration in the vegetative organs, while male inflorescences had the highest levels in the reproductive organs. Notably, stipe and fruits were the vegetative and reproductive organs with the highest B accumulation, which increased with plant age. In older plants, the largest amount of B exported occurred in bunches. Furthermore, the rates of B immobilization and recycling were higher than the amounts of B exported by oil palm trees. The results of this study have important implications for the nutritional management of B in oil palm crops. Given that B is the most limiting micronutrient in palm oil crop in the Amazon. In conclusion, this study provides a comprehensive understanding of the dynamics of B in oil palm plants, which could help unlock their full potential and promote sustainable crop management. This research highlights the importance of nutrient management to increase crop yield and sustainability.
Genome sequence and characterization of a novel ourmia-like virus infecting Botryosphaeria dothidea in China
Authors: Song Xinzheng , Wang Yanfen , Li Changshui , Xie Shunpei , Yin Xinming , Guo Yashuang , Geng Yuehua , Guo Lihua , Wu Haiyan , Zhang Meng 
Published: April 2023

Abstract
Here, we describe the complete genome sequence and molecular characterization of a novel ourmia-like virus, tentatively named “Botryosphaeria dothidea ourmia-like virus 3” (BdOLV3), isolated from the phytopathogenic fungus Botryosphaeria dothidea strain ZM190712-1, associated with branch dieback of walnut in Henan Province, China. The complete BdOLV3 genome is 2247 nucleotides (nt) in length, with a content of 31.55% G, 16.11% A, 23.54% U, and 28.79% C. The BdOLV3 genome contains a single large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp) of 612 amino acids (aa) with a molecular mass of 67.68 kDa. This RdRp protein contains a catalytic core domain associated with ourmia-like virus in the family Botourmiaviridae. A phylogenetic tree revealed that the novel ourmia-like virus clustered with members of the genus Magoulivirus and was separate from members of the other eleven genera of the family Botourmiaviridae.