bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Free-Standing Riser Concept for Deepwater Developments
Authors: Bomfimsilva Carlos Terencio Pires , Netto Theodoro Antoun 
Published: June 2023

Abstract
Free-standing hybrid risers (FSHR) are well established in deepwater field developments in the oil and gas industry. The major advantages foreseen for the FSHR are the possibility of safely anticipating production and requiring significantly reduced payloads at the floating production unit. This work addresses the feasibility of a novel proposed optimized concept, the free-standing integrated riser (FSIR), where the pipeline is integrated into the riser by means of a transition section, which is kept in place by a multiple line mooring system, developed to keep the functionality and integrity of the entire riser along its lifetime. The work provides the findings from numerical analysis simulated in orcaflex, a finite element simulation software dedicated to global analysis of risers, considering the design criteria provided in API 2RD Standard. As part of the FSIR evaluation, screening static analysis was performed to identify the most promising configurations for the multiple line mooring system, followed by a series of dynamic analyses to evaluate the behavior of the riser in extreme conditions. In addition, several investigations were performed to assess the functionality and the robustness of the system, including parametric studies to check for installation and dimensional tolerances, assessment of fatigue damage, and checking the impact of pipe size on the design. The results show that the proposed novel FSIR concept can provide a practical and economical solution for deepwater projects.
Cobalt mineralogy at the Iron Creek deposit, Idaho cobalt belt, USA: Implications for domestic critical mineral production
Authors: Holley E.A. , Zaronikola N. , Trouba J. , Pfaff K. , Thompson J. , Spiller E. , Anderson C. , Eggert R. 
Published: June 2023

AbstractCurrent U.S. policies aim to establish domestic supply chains of critical minerals for the energy transition. The Iron Creek deposit in the Idaho cobalt belt (ICB) is one of the most promising cobalt (Co) targets. Our case study illustrates the importance of mineralogy in strategic evaluations of critical mineral potential. Most of the Co at Iron Creek occurs as Fe substitution in pyrite, with lattice-bound and inclusion-hosted Ag, As, Bi, Ni, Pb, Se, Te ± trace Au and Sb. Cobalt also occurs in minor cattierite-vaesite. The Co minerals are intergrown with Co-poor chalcopyrite hosting Cu ± minor In and Zn. Worldwide, most Co is recovered from deposits mineralogically distinct from the ICB, and the United States currently lacks infrastructure to recover this Co and its associated metals. ICB ore minerals could be processed by autoclave, roaster, smelter, bioleach, or heap leach. Recovery of the Ag, As, Au, Bi, In, Pb, Se, Te, and Zn would be costly by autoclave, and construction of a custom smelter for ICB ores is likely uneconomic, so these elements would become waste irrespective of criticality. The Co-Fe and Co-As sulfide minerals are most suitable for Co and Ni recovery by a hydrometallurgical autoclave process, with potential pretreatment of cobaltiferous pyrite/arsenopyrite in an inert-atmosphere roaster, in new domestic or anticipated international facilities. The ICB is the second largest known Co resource in the United States. Consideration of ore mineralogy in the ICB is essential in strategies for domestic production.
Subclinical congestion assessed by lung ultrasound in ST segment elevation myocardial infarction
Authors: Carreras-Mora José , Simón-Ramón Clara , Vidal-Burdeus María , Rodríguez-Sotelo Laura , Sionis Alessandro , Giralt-Borrell Teresa , Izquierdo-Marquisá Andrea , Rodríguez-González Clara , Farré Núria , Cainzos-Achirica Miguel , Tizón-Marcos Helena , Garcia-Picart Joan , Milà-Pascual Laia , Vaquerizo Beatriz , Rivas-Lasarte Mercedes , Ribas-Barquet Núria 
Published: June 2023

ObjectiveWe evaluated the prognostic value of subclinical congestion assessed by lung ultrasound (LUS) in patients admitted for ST segment elevation myocardial infarction (STEMI).MethodsThis was a multicentre study that prospectively enrolled 312 patients admitted for STEMI without signs of heart failure (HF) at admission. LUS was performed during the first 24 hours after revascularisation and classified patients as having either wet lung (three or more B-lines in at least one lung field) or dry lung. The primary endpoint was a composite of acute HF, cardiogenic shock or death during hospitalisation. The secondary endpoint was a composite of readmission for HF or new acute coronary syndrome or death during 30-day follow-up. Zwolle score was calculated in all patients to assess predictive improvement by adding the result of the LUS to this score.Results14 patients (31.1%) in the wet lung group presented the primary endpoint vs 7 (2.6%) in the dry lung group (adjusted RR 6.0, 95% CI 2.3 to 16.2, p=0.007). The secondary endpoint occurred in five patients (11.6%) in the wet lung group and in three (1.2%) in the dry lung group (adjusted HR 5.4, 95% CI 1.0 to 28.7, p=0.049). Addition of LUS improved the ability of the Zwolle score to predict the follow-up composite endpoint (net reclassification improvement 0.99). LUS showed a very high negative predictive value in predicting in-hospital and follow-up endpoints (97.4% and 98.9%, respectively).ConclusionEarly subclinical pulmonary congestion identified by LUS in patients with Killip I STEMI at hospital admission is associated with adverse outcomes during hospitalisation and 30-day follow-up.
Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans
Authors: Angelini Elsa D , Yang Jie , Balte Pallavi P , Hoffman Eric A , Manichaikul Ani W , Sun Yifei , Shen Wei , Austin John H M , Allen Norrina B , Bleecker Eugene R , Bowler Russell , Cho Michael H , Cooper Christopher S , Couper David , Dransfield Mark T , Garcia Christine Kim , Han MeiLan K , Hansel Nadia N , Hughes Emlyn , Jacobs David R , Kasela Silva , Kaufman Joel Daniel , Kim John Shinn , Lappalainen Tuuli , Lima Joao , Malinsky Daniel , Martinez Fernando J , Oelsner Elizabeth C , Ortega Victor E , Paine Robert , Post Wendy , Pottinger Tess D , Prince Martin R , Rich Stephen S , Silverman Edwin K , Smith Benjamin M , Swift Andrew J , Watson Karol E , Woodruff Prescott G , Laine Andrew F , Barr R Graham 
Published: June 2023

BackgroundTreatment and preventative advances for chronic obstructive pulmonary disease (COPD) have been slow due, in part, to limited subphenotypes. We tested if unsupervised machine learning on CT images would discover CT emphysema subtypes with distinct characteristics, prognoses and genetic associations.MethodsNew CT emphysema subtypes were identified by unsupervised machine learning on only the texture and location of emphysematous regions on CT scans from 2853 participants in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS), a COPD case–control study, followed by data reduction. Subtypes were compared with symptoms and physiology among 2949 participants in the population-based Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study and with prognosis among 6658 MESA participants. Associations with genome-wide single-nucleotide-polymorphisms were examined.ResultsThe algorithm discovered six reproducible (interlearner intraclass correlation coefficient, 0.91–1.00) CT emphysema subtypes. The most common subtype in SPIROMICS, the combined bronchitis-apical subtype, was associated with chronic bronchitis, accelerated lung function decline, hospitalisations, deaths, incident airflow limitation and a gene variant nearDRD1, which is implicated in mucin hypersecretion (p=1.1 ×10−8). The second, the diffuse subtype was associated with lower weight, respiratory hospitalisations and deaths, and incident airflow limitation. The third was associated with age only. The fourth and fifth visually resembled combined pulmonary fibrosis emphysema and had distinct symptoms, physiology, prognosis and genetic associations. The sixth visually resembled vanishing lung syndrome.ConclusionLarge-scale unsupervised machine learning on CT scans defined six reproducible, familiar CT emphysema subtypes that suggest paths to specific diagnosis and personalised therapies in COPD and pre-COPD.
SN1987A neutrino burst: limits on flavor conversion
Authors: Dedin Neto Pedro , dos Santos Marcos V. , de Holanda Pedro Cunha , Kemp Ernesto 
Published: June 2023

AbstractIn this paper, we revisit the SN1987A neutrino data to see its constraints on flavor conversion. We are motivated by the fact that most works that analyze this data consider a specific conversion mechanism, such as the MSW (Mikheyev–Smirnov–Wolfenstein) effect, although flavor conversion is still an open question in supernovae due to the presence of neutrino–neutrino interactions. In our analysis, instead of considering a specific conversion mechanism, we let the electron antineutrino survival probability $$P_{{\overline{e}}{\overline{e}}}$$

P

e
¯

e
¯

be a free parameter. We fit the data from Kamiokande-II, Baksan, and IMB detected spectrum with two classes of models: time-integrated and time-dependent. For the time-integrated model, it is not possible to put limits above $$1\sigma $$

1
σ

(68% confidence level) on the survival probability. The same happens for the time-dependent model when cooling is the only mechanism of antineutrino emission. However, for models considering an accretion phase, $$P_{{\overline{e}}{\overline{e}}}\sim 0$$

P

e
¯

e
¯

∼
0

is strongly rejected, showing a preference for the existence of an accretion component in the detected antineutrino flux, and a preference for normal mass ordering when only the MSW is present.
Detection of baby food sterilized with ionizing radiation using thermoluminescence
Authors: Kazakis N. A. , Betsou Ch. 
Published: June 2023

AbstractFood sterilization with ionizing radiation is a well-established technology, which is constantly extending to several products due to its numerous advantages. However, radiosterilization is prohibited to several food categories, such as baby food products since it could cause nutrient degradation of such foods with significant effects on the infants’ health. As a result, any governmental agency responsible for the detection of irradiated products should first focus on products consumed by babies/children. To this respect, the present work explores whether TL can be employed as a method for post-sterilization dosimetry on baby food, by studying the properties of their glass containers since they would be equally and jointly exposed to the ionizing radiation during the sterilization process. Two different reputable brands, i.e., Hipp® and Nestle®, are used for this purpose. Both glass containers exhibit a linear TL dose response for doses up to 3 kGy, while no sensitization of the main peaks is observed. Though their behavior is not very stable with time (strong fading) yet fading correction is possible. Dose recovery tests were successfully conducted, calculating the administered dose with high accuracy. A computerized curve deconvolution analysis (CCDA) was also performed revealing that all glow curves can be fitted with one peak of continuous trap distribution and three discrete-energy peaks, which also demonstrate a linear dose response over the range 50–3000 Gy. Thus, findings are very promising towards the post-sterilization dosimetry of baby food through their glass containers.
CR-39 detector-based Radon dosimetry system calibration in the self-decay mode
Authors: Lüley J. , Filova V. , Blahušiak P. , Vrban B. , Čerba Š. , Bonková I. , Nečas V. 
Published: June 2023

AbstractThis paper describes cooperation of the Slovak University of Technology in Bratislava (STU) and the Slovak Institute of Metrology (SMU) in the verification of the calibration factors for the solid-state nuclear track detector utilized for radon dosimetry and establishing traceability for the STU laboratory. The SMU operates the Air Radon Standard which consists of a radon chamber and calibrated radon atmosphere monitoring system. A specification of the radon chamber is that the radon concentration changes during the exposure time. The radon atmosphere is created by the insertion of a specified amount of radon gas into the chamber, which subsequently decays over time. The STU laboratory is equipped with the TASLImage™ system for radon dosimetry with corresponding TASTRAK CR-39 type detectors and diffusion chambers. These chambers allow radon to diffuse inside and prevent dust and radon progeny to enter the container. Each diffusion container is characterized by its own diffusion rate, which should be considered in the metrology calibration approach, especially when the radon chamber is operated in the decay mode. Therefore, several measurements were carried out to determine the optimal condition for conversion factor verification. The experiments were conducted for low radon concentrations, but still in the range that the radon chamber can reliably provide (100 Bq m−3 to 100 kBq m−3) and in combination with several times of exposure. Based on the achieved results the default calibration factor was verified, and an optimal calibration approach was proposed. To improve the capability of the radon measurement, a custom diffusion container design was proposed. The design incorporates compact dimensions with an aerosol filter at the entrance to the container. This allows to increase in an entry hole and thus increases the diffusion rate. Subsequently, the homogeneity of the radon atmosphere in the chamber was tested.
Abstract A013: Minor intron splicing is critical for survival of lethal prostate cancer
Authors: Augspach Anke , Rubin Mark Andrew , Kanadia Rahul 
Published: June 2023

Abstract
The role of major intron splicing in PCa is well established and highly investigated. However, the equally important and impactful minor spliceosome (MiS) and minor intron splicing have remained underexplored in PCa. Here for the first time, we show that minor intron containing genes (MIGs) are enriched as direct interactors of PCa-causing genes and that their expression levels correspond to different stages of PCa progression. Accordingly, we show that U6atac expression and MiS activity reinforces cell growth and correlates with PCa progression. Consequently, highly proliferative PCa cells are strongly susceptible to siU6atac-mediated MiS inhibition. In this sense, siU6atac is significantly more efficient in lowering the tumor burden of castration resistant prostate cancer (CRPC) cells and organoids than the current state-of-the-art combination therapy. Mechanistically, we show that inhibition of the MiS through siU6atac causes minor and major intron mis-splicing and aberrant expression of MIG and non-MIG transcripts and encoded proteins, which enriches for MAPK activity, DNA repair, and cell cycle. Single cell-RNAseq confirms cell cycle defects and lineage dependency on the MiS from primary to CRPC and neuroendocrine PCa. Finally, our data provides strong evidence that Androgen receptor signaling functions as a regulator of MiS activity throughout PCa disease progression to CRPC while p38MAPK influences MiS activity in neuroendocrine PCa. Furthermore, we discovered that MiS inhibition in neuroendocrine PCa shifts alternative splicing in favor of canonical REST1 isoform thereby blocking lineage plasticity and progression to lethal therapy resistant PCa. This finding positions the MiS as yet another disruptor of a crucial molecular pathway underpinning the emergence of CRPC and neuroendocrine PCa. Based on these findings we posit that the MiS may be a common denominator of prominent PCa driver genes and a driving factor of advanced lethal PCa. We hypothesize that the MiS represents a point of vulnerability in therapy-resistant PCa.
Citation Format: Anke Augspach, Mark Andrew Rubin, Rahul Kanadia. Minor intron splicing is critical for survival of lethal prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A013.
Abstract A026: BMX inhibition reverses HSD3B1-driven resistance in prostate cancer
Authors: Li Xiuxiu , Berk Michael , Goins Christopher , Alyamani Mohammad , Chung Yoon-Mi , Wang Chenyao , Patel Monaben , Rathi Nityam , Zhu Ziqi , Willard Belinda , Stauffer Shaun , Klein Eric , Sharifi Nima 
Published: June 2023

Abstract
Background: Prostate cancer is the second leading cause of cancer-related death in men in the United States and is dependent on androgens and androgen receptor (AR) activation. Androgen deprivation therapy (ADT) is the mainstay treatment, but it as well as next-generation treatments eventually fail. Disease then progresses as castration-resistant prostate cancer (CRPC), which is driven by reactivation of the androgen-AR axis. 3β-hydroxysteroid dehydrogenase-1 (3βHSD1) catalyzes the rate-limiting step for potent androgen synthesis from adrenal-derived precursors, thereby stimulating CRPC. HSD3B1, which encodes for 3βHSD1, has a common missense-encoding germline variation that enhances conversion from adrenal DHEA to potent androgens. Clinical studies demonstrate that this “adrenal-permissive” HSD3B1 genotype confers more rapid progression on ADT, and recent studies show that overall survival is shorter in patients with the adrenal-permissive genotype who are treated with ADT + enzalutamide. The Etk/BMX kinase may be involved in the development and progression of CRPC. We sought to determine whether phosphorylation of 3βHSD1 is required for its activation and that the necessary kinase could be a potential target. Methods: In prostate cancer lines, mouse xenograft models, and fresh patient prostatectomy tissues, mass spectrometry and HPLC were used to identify steroid metabolites. Genetic and pharmacological methods were used to identify inhibition of BMX-mediated 3βHSD1 phosphorylation in CRPC. Results: BMX inhibition suppressed castration-resistant prostate cancer through targeting 3βHSD1 phosphorylation. 3βHSD1 transcription level and enzyme activity were induced in enzalutamide-resistant prostate cancer cell lines. 3βHSD1 and SF-1 transcription levels were positively correlated in prostate adenocarcinoma (TCGA database). BMX inhibition by zanubrutinib suppressed enzalutamide resistance induced 3βHSD1 enzyme activity. Conclusions: BMX promotes CRPC by regulating 3βHSD1 phosphorylation. BMX inhibition has potential as a new therapy to optimize CRPC treatment.
Citation Format: Xiuxiu Li, Michael Berk, Christopher Goins, Mohammad Alyamani, Yoon-Mi Chung, Chenyao Wang, Monaben Patel, Nityam Rathi, Ziqi Zhu, Belinda Willard, Shaun Stauffer, Eric Klein, Nima Sharifi. BMX inhibition reverses HSD3B1-driven resistance in prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A026.
Abstract A070: Determining gene expression regulated by androgen receptor variant 7 in co-loss of MAP3K7/CHD1 prostate cancer
Authors: Gillette Claire , Jillson Lauren , Cramer Scott 
Published: June 2023

Abstract
Prostate cancer (PCa) is the second leading cancer diagnosis in men. The ACS estimates 268,490 new cases of PCa and 34,500 deaths in 2022. Most patients with local PCa are disease free at the 5-year mark. Patients with metastatic PCa only have a 31% 5-year disease-free survival rate. While these patients may initially respond to androgen deprivation therapy, many will progress to castration-resistant prostate cancer (CRPC) and fail treatment. There is a need to develop new therapies to treat CRPC. The Cramer lab studies the dual deletion of MAP3K7 and CHD1 PCa subtype. In MAP3K7/CHD1-depleted PCa cell lines the ratio of AR splicing variants shifts to enrich for the constitutively active variant AR-v7, a known driver of CRPC. Other studies demonstrated that AR-v7 has unique target genes and can alter canonical AR target gene expression. I hypothesize that gain of AR-v7 signaling activates atypical gene targets which alter the gene expression of MAP3K7/CHD1-depleted PCa. I will determine the chromatin-binding targets and identify AR-v7 specific candidate genes. Patients with loss of MAP3K7 and CHD1 also enrich in the spliceosome protein U2AF2, therefore I will also perform transcriptomics with/without AR-FL and AR-v7 to characterize the larger impacts of AR-variant signaling at the RNA level. To this end, I will develop an inducible knockdown system in dual shMAP3K7/shCHD1 cells targeting AR-FL, AR-v7, and AR-Total. This will provide insight into the role of AR-v7 in two stages of gene expression and identify candidate therapeutic genes/pathways in loss of MAP3K7 and CHD1 PCa.
Citation Format: Claire Gillette, Lauren Jillson, Scott Cramer. Determining gene expression regulated by androgen receptor variant 7 in co-loss of MAP3K7/CHD1 prostate cancer [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A070.
Abstract A085: A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesis
Authors: Luo Fu , Tshering Lara F. , Tutuska Karis , Szenk Mariola , Rubel Diana , Rail James G. , Russ Savanah , Liu Jingxuan , Nemajerova Alice , Balázsi Gábor , Talos Flaminia 
Published: June 2023

Abstract
Cellular heterogeneity poses tremendous challenges for developing cell-targeted therapies and biomarkers of clinically significant prostate cancer. The origins of this heterogeneity within the cellular complexities of normal adult and aging tissue remain unknown leaving important cellular states and transcriptional programs that allow the expansion of malignant clones in early cancer unidentified. These unresolved questions hamper the development of novel therapies designed to block the deregulated proliferation of prostate epithelial cells. To define cell states that contribute to early cancer development, we performed in vivo lineage tracing with multicolor reporters, whole organ mapping and single cell transcriptomics of normal and malignant prostate from genetically-engineered mouse models. We show here that the long-term luminal homeostasis is maintained by multiple clones with various fitness levels. Long-term clonal expansions are enabled by a luminal transcriptional state harboring basal markers (Luminal Intermediate, LumI) and controlled by Wnt/p63 signaling. Moreover, LumI cells greatly expand during early stages of tumorigenesis in several mouse models of prostate cancer. Specific genetic ablation of p63 from luminal cells in vivo decreases clonal activity in homeostasis and reduces the formation of aggressive clones in prostate tumor models. Finally, the LumI cells and Wnt signaling appear to significantly increase in human aging prostate and prostate cancer samples, highlighting the importance of this hybrid cell state for human pathologies with potential translational impact. Our models reveal a continuity of this cell state from normal homeostasis to aging and early cancer with specific alterations at each stage. Understanding how the luminal intermediate cell state is regulated in homeostasis and deregulated in hyperproliferative contexts is crucial for the development of prognostic markers and new therapeutic interventions for prostate diseases.
Citation Format: Fu Luo, Lara F. Tshering, Karis Tutuska, Mariola Szenk, Diana Rubel, James G. Rail, Savanah Russ, Jingxuan Liu, Alice Nemajerova, Gábor Balázsi, Flaminia Talos. A luminal intermediate cell state maintains long-term prostate homeostasis and contributes to tumorigenesis [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A085.