bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic interaction of injected liquid jet with skin layer interfaces revealed by microsecond imaging of optically cleared ex vivo skin tissue model
Authors: Mohizin Abdul , Imran Jakir Hossain , Lee Kee Sung , Kim Jung Kyung 
Published: February 2023

Abstract
Background
Needle-free jet injection (NFJI) systems enable a controlled and targeted delivery of drugs into skin tissue. However, a scarce understanding of their underlying mechanisms has been a major deterrent to the development of an efficient system. Primarily, the lack of a suitable visualization technique that could capture the dynamics of the injected fluid–tissue interaction with a microsecond range temporal resolution has emerged as a main limitation. A conventional needle-free injection system may inject the fluids within a few milliseconds and may need a temporal resolution in the microsecond range for obtaining the required images. However, the presently available imaging techniques for skin tissue visualization fail to achieve these required spatial and temporal resolutions. Previous studies on injected fluid–tissue interaction dynamics were conducted using in vitro media with a stiffness similar to that of skin tissue. However, these media are poor substitutes for real skin tissue, and the need for an imaging technique having ex vivo or in vivo imaging capability has been echoed in the previous reports.

Methods
A near-infrared imaging technique that utilizes the optical absorption and fluorescence emission of indocyanine green dye, coupled with a tissue clearing technique, was developed for visualizing a NFJI in an ex vivo porcine skin tissue.

Results
The optimal imaging conditions obtained by considering the optical properties of the developed system and mechanical properties of the cleared ex vivo samples are presented. Crucial information on the dynamic interaction of the injected liquid jet with the ex vivo skin tissue layers and their interfaces could be obtained.

Conclusions
The reported technique can be instrumental for understanding the injection mechanism and for the development of an efficient transdermal NFJI system as well.
Incidence of near-death experiences in patients surviving a prolonged critical illness and their long-term impact: a prospective observational study
Authors: Rousseau Anne-Françoise , Dams Laurence , Massart Quentin , Choquer Laila , Cassol Héléna , Laureys Steven , Misset Benoit , Dardenne Nadia , Gosseries Olivia , Martial Charlotte 
Published: February 2023

Abstract
Background
So far, the few prospective studies on near-death experience (NDE) were carried out only in intensive care unit (ICU) patients with homogeneous aetiologies, such as cardiac arrest or trauma survivors. The aims of this 1-year prospective and monocentric study were to investigate the incidence of NDE in ICU survivors (all aetiologies) as well as factors that may affect its frequency, and to assess quality of life up to 1 year after enrolment.

Methods
We enrolled adults with a prolonged ICU stay (> 7 days). During the first 7 days after discharge, all eligible patients were assessed in a face-to-face interview for NDE using the Greyson NDE scale, dissociative experiences using the Dissociative Experience Scale, and spirituality beliefs using the WHOQOL-SRPB. Medical parameters were prospectively collected. At 1-year after inclusion, patients were contacted by phone to measure quality of life using the EuroQol five-dimensional questionnaire.

Results
Out of the 126 included patients, 19 patients (15%) reported having experienced a NDE as identified by the Greyson NDE scale (i.e. cut-off score ≥ 7/32). In univariate analyses, mechanical ventilation, sedation, analgesia, reason for admission, primary organ dysfunction, dissociative and spiritual propensities were associated with the emergence of NDE. In multivariate logistic regression analysis, only the dissociative and spiritual propensity strongly predicted the emergence of NDE. One year later (n = 61), the NDE was not significantly associated with quality of life.

Conclusions
The recall of NDE is not so rare in the ICU. In our cohort, cognitive and spiritual factors outweighed medical parameters as predictors of the emergence of NDE.
Trial registration This trial was registered in Clinicaltrials.gov in February 2020 (NCT04279171).
Proactive and Integrated Management and Empowerment in Parkinson’s Disease protocol for a randomised controlled trial (PRIME-UK) to evaluate a new model of care
Authors: Lithander Fiona E. , Tenison Emma , Ypinga Jan , Halteren Angelika , Smith Matthew D. , Lloyd Katherine , Richfield Edward W. , Brazier Danielle E. , Ó Breasail Mícheál , Smink Agnes J. , Metcalfe Chris , Hollingworth William , Bloem Bas , Munneke Marten , Ben-Shlomo Yoav , Darweesh Sirwan K. L. , Henderson Emily J. 
Published: February 2023

Abstract
Background
People living with Parkinson’s disease experience progressive motor and non-motor symptoms, which negatively impact on health-related quality of life and can lead to an increased risk of hospitalisation. It is increasingly recognised that the current care models are not suitable for the needs of people with parkinsonism whose care needs evolve and change as the disease progresses. This trial aims to evaluate whether a complex and innovative model of integrated care will increase an individual’s ability to achieve their personal goals, have a positive impact on health and symptom burden and be more cost-effective when compared with usual care.

Methods
This is a single-centre, randomised controlled trial where people with parkinsonism and their informal caregivers are randomised into one of two groups: either PRIME Parkinson multi-component model of care or usual care. Adults ≥18 years with a diagnosis of parkinsonism, able to provide informed consent or the availability of a close friend or relative to act as a personal consultee if capacity to do so is absent and living in the trial geographical area are eligible. Up to three caregivers per patient can also take part, must be ≥18 years, provide informal, unpaid care and able to give informed consent. The primary outcome measure is goal attainment, as measured using the Bangor Goal Setting Interview. The duration of enrolment is 24 months. The total recruitment target is n=214, and the main analyses will be intention to treat.

Discussion
This trial tests whether a novel model of care improves health and disease-related metrics including goal attainment and decreases hospitalisations whilst being more cost-effective than the current usual care. Subject to successful implementation of this intervention within one centre, the PRIME Parkinson model of care could then be evaluated within a cluster-randomised trial at multiple centres.
Virtually supported penicillin allergy de-labelling during COVID-19
Authors: Ghassemian Arian , Sadi Geetanjalee , Mak Raymond , Erdle Stephanie , Wong Tiffany , Jeimy Samira 
Published: February 2023

Abstract
Background
Penicillin allergy is a commonly listed medication allergy despite rare overall incidence. Many patients erroneously have this label, which has personal, health, and societal costs. Penicillin allergy delabelling requires an oral challenge, which can be a rate limiting step in the de-labeling process; this is even more relevant with the reduction of in-person visits during the COVID-19 pandemic.

Objective
To identify the utility and broader applicability of using a virtually supported platform, initially adopted given COVID-19 restrictions, to expedite penicillin oral provocation challenge and penicillin de-labeling in patients at low to moderate risk of immediate hypersensitivity reaction and based on shared decision making.

Methods
Patients in Vancouver catchment area were referred for penicillin allergy and virtually assessed by the consulting allergist between July 2020 and April 2021. Those deemed appropriate for oral challenge based on the allergist consultant were offered the option of a virtual oral provocation challenge to oral amoxicillin in a subsequent virtual visit. Patients who agreed and were consented underwent a virtually supervised oral amoxicillin challenge during the second virtual visit. Findings are summarized in this case series.

Results
Twenty-three patients, both adult and pediatric, ranging from no to significant co-morbidities were consented and underwent the virtual challenge. One hundred percent of patients were successful with no reaction after an hour post virtual oral provocation challenge with amoxicillin.

Conclusion
Virtual medicine is likely to remain in the allergist’s practice. Virtually supported penicillin allergy delabelling, based on shared decision making and risk stratification, presents another pathway for penicillin allergy delabelling.
DRESS syndrome due to iodinated contrast media. A case report
Authors: Zambrano Ibarra G. , Noguerado Mellado B. , Tornero Molina P. , Cuevas Bravo C. , Rojas Pérez-Esquerra P. 
Published: February 2023

Abstract
Background
The most frequent non-immediate reactions described with iodinated contrast media (ICM) are mild to moderate, however, some cases of patients with severe non-immediate reactions, such as drug eruption with eosinophilia and systemic symptoms (DRESS) have been described.

Case presentation
An 84-year-old patient developed DRESS syndrome after administration of ICM ioversol. The patient fullfilled the RegiSCAR diagnostic criteria for DRESS (definite score = 6). He underwent intradermal skin testing (IDT) with the widest panel of ICM available at our center. IDT was positive with ioversol and iomeprol. A punch biopsy was performed on the positive IDT with the culprit drug (ioversol) and histopathology was compatible with a T-cell mediated mechanism.

Conclusion
In this case, the IDT-positive biopsy was consistent with DRESS syndrome caused by T-lymphocyte activation, supporting the clinical diagnosis.
Radiographic quantification of the normal and near-normal coxofemoral conformation in Labrador Retrievers and German Shepherds: a comparative study
Authors: Nahla Menna A. , Berry Clifford R. , Mostafa Ayman A. 
Published: February 2023

AbstractBackgroundCanine hip dysplasia (CHD) is a multifactorial disease affecting large breed dogs with associated joint laxity and incongruity that predisposes them to osteoarthritis. The purpose of the study is to objectively compare the conformation of normal and near-normal coxofemoral joints (CFJS) in Labrador Retrievers versus German Shepherds on the extended ventrodorsal radiograph. Investigated groups were categorized as normal and near-normal CFJSaccording to the morphometric criteria established by the FCI scoring system. Center-edge (CE) angle, Norberg angle (NA), indices of dorsal AFH coverage width and area, acetabular slope (AS) angle, and inclination angle were determined for each group. CE angle and AS angle were modified from previously described human techniques. The width and area of dorsal AFH coverage were standardized by the corresponding femoral head diameter and area. Variables were compared between groups using an unpaired, two-tailedt-test. A Spearman correlation coefficient determined the relationship between selected variables.ResultsIn Labradors, CE angle (lateral coverage) and dorsal AFH coverage area index (dorsal coverage) were greater in normal versus near-normal CFJS. In German Shepherds, lateral AFH coverage (CE angle and NA) was greater in normal versus near-normal hip joints; whereas, dorsal AFH coverage did not differ between the two groups. Lateral AFH coverage was greater in normal versus near-normal CFJSof both breeds. In Labradors, the inclination angle was greater in near-normal versus normal CFJS. Normal CFJSof Labradors revealed greater lateral and dorsal AFH coverages compared to German Shepherds. Near-normal joints of Labradors showed greater lateral AFH coverage compared to those of German Shepherds; whereas, dorsal AFH coverage did not differ between the two breeds. A steeper acetabular slope angle was noted in normal and near-normal CFJSof German Shepherds compared to Labrador Retrievers. The inclination angle of near-normal joints was greater in Labrador Retrievers compared to German Shepherds.ConclusionsOverall, normal and near-normal CFJSof German Shepherds had lesser AFH coverage and steeper acetabular slope angle compared to Labrador Retrievers. Labrador Retrievers and German Shepherds with CE-angles < 27° and < 21.8°, dorsal AFH coverage width indices < 51 and < 49%, and/or dorsal AFH coverage area indices < 53 and < 50%, respectively, may be consistent with CHD. Thus, the authors would recommend excluding subjects with lower values from breeding. Validating the reported measurements is still warranted.
Optimal partial regularity for very weak solutions to a class of nonlinear elliptic systems
Authors: Chen Shuhong , Tan Zhong 
Published: February 2023

AbstractWe consider optimal partial regularity for very weak solutions to a class of nonlinear elliptic systems and obtain the general criterion for a very weak solution to be regular in the neighborhood of a given point. First, by Hodge decomposition and the technique of filling holes, we establish the relation between the very weak solution and the classical weak solution. Furthermore, combining the technique of p-harmonic approximation with the method of Hodge decomposition, we obtain the partial regularity result. In particular, the partial regularity we obtained is optimal.
A new closed analytical solution for the elastodynamic half-space Green’s function
Authors: Sánchez-Sesma Francisco J. , Luzón Francisco , García-Jerez Antonio , Perton Mathieu , Sáenz-Castillo Mario A. , Sierra-Álvarez César A. 
Published: February 2023

AbstractThe elastodynamic half-space Green’s function has been the subject of research for more than a century since the Lamb’s classical solution. Here, we revisit the problem and present a new closed analytical solution, in frequency domain, based upon the Principle of Equipartition (EQP) of Energy. This principle asserts that the imaginary parts of the Green’s tensor components equal the average cross-correlations of the fields generated by the uniform incidence of P and S body waves and by Rayleigh surface waves with amplitudes weighted by partition factors. The real part of the Green’s function is the Hilbert transform of the imaginary part. We validate our results by comparing synthetic seismograms of well-known solutions for surface and buried forces and discuss the implications of this new solution. Constructing synthetic diffuse fields is a first step for identifying them in nature.
Graphical Abstract
Analyzing gender differentials in dietary diversity across urban and peri-urban areas of Hyderabad, India
Authors: Marla Kiran Suryasai , Padmaja Ravula 
Published: February 2023

Abstract
Background
India’s recent increase in urbanization alongside with feminization of rural agriculture could increase the existing gender disparities in dietary diversity. With many rural men migrating to urban areas, women have increased domestic burdens as well as productive burdens such as making informed crop production decisions so household members consume a diverse diet. Given the rapid and recent onset of this phenomenon, there is a need to explore gender differentials in diet diversity across urban and rural areas to assess if certain populations are being disproportionately impacted by this trend. There are limited established quantitative studies discussing this gender disparity with respect to urbanization. Therefore, this paper compares dietary diversity among adult men, adult women, adolescent males, and adolescent females in urban and peri-urban locations. The authors also assess if various sociodemographic factors correlate with dietary diversity.

Methods
Analyses were conducted on dietary diversity data collected by the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) from selected urban (1108 individuals) and peri-urban (808 individuals) locations of Hyderabad, India. The total sample size of the population is n = 1816: 660 adult males, 662 adult females, 205 adolescent males, and 289 adolescent females.

Results
Adult women and adolescent females have a higher diet disparity between peri-urban and urban areas when compared to adult males and adolescent males. Multivariate analyses followed by post hoc multiple comparisons testing further support that peri-urban adult women consume a less diverse diet compared to their urban counterparts and less than other peri-urban adult men and adolescent women. It was also found that marital status, type of household card owned, and the highest degree of education are statistically significant correlators of an individual’s dietary diversity.

Conclusions
Given that urbanization could negatively impact already vulnerable populations such as peri-urban adult women, who play a key role in children’s nutrition, it is important to provide support to these populations. This paper suggests it is possible to do so through government subsidization of peri-urban farmers to grow more diverse crops, fortifying easily accessible foods with commonly lacking micronutrients, including Vitamin A, folic acid, and iron, market access, and affordable prices.
A case report of lingual nerve injury after a prolonged laparoscopic cholecystectomy using supraglottic airway device (i-gel®)
Authors: Afifi Mohamed , Cozma Stefan 
Published: February 2023

Abstract
Background
This is a case report of postoperative tongue numbness after a prolonged laparoscopic cholecystectomy using i-gel®.

Case presentation
A female patient 62 years old, ASA physical status II and with weight 72.7 kg, height 159 cm and BMI 28.8 kg/m2 had general anaesthesia using i-gel size 4 as artificial airway; vital data was stable and within normal range all through the surgery, the surgery was complicated due to the presence of intra-abdominal adhesions and the surgery was prolonged to 90 min With the insertion of surgical drains, she mentioned tongue numbness at the tip of the tongue on postoperative day 1, and this was completely resolved 4 weeks later on further follow-up.

Conclusions
We conclude that postoperative tongue numbness is one of the complications that should be highlighted after the i-gel®.
Screening crucial lncRNAs and genes in osteoarthritis by integrated analysis
Authors: Wang Jun , Zhang Yumin , Ma Tao , Wang Tao , Wen Pengfei , Song Wei , Zhang Binfei 
Published: February 2023

Abstract
Background
Osteoarthritis (OA) is one of the most frequent chronic diseases with high morbidity worldwide, marked by degradation of the cartilage and bone, joint instability, stiffness, joint space stenosis and subchondral sclerosis. Due to the elusive mechanism of osteoarthritis (OA), we aimed to identify potential markers for OA and explore the molecular mechanisms underlying OA.

Methods
Expression profiles data of OA were collected from the Gene Expression Omnibus database to identify differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs) in OA. Functional annotation and protein–protein interaction (PPI) networks were performed. Then, nearby DEmRNAs of DElncRNAs was obtained. Moreover, GO and KEGG pathway enrichment analysis of nearby DEmRNAs of DElncRNAs was performed. Finally, expression validation of selected mRNAs and lncRNAs was performed by quantitative reverse transcriptase-polymerase chain reaction.

Results
In total, 2080 DEmRNAs and 664 DElncRNAs were determined in OA. PI3K-Akt signaling pathway, Endocytosis and Rap1 signaling pathway were significantly enriched KEGG pathways in OA. YWHAB, HSPA8, NEDD4L and SH3KBP1 were four hub proteins in PPI network. The AC093484.4/TRPV2 interact pair may be involved in the occurrence and development of OA.

Conclusion
Our study identified several DEmRNAs and DElncRNAs associated with OA. The molecular characters could provide more information for further study on OA.
Modelling the super-infection of two strains of dengue virus
Authors: Eegunjobi Adetayo Samuel , Anyanwu Michael Chimezie , Neossi-Nguetchue S. N. 
Published: February 2023

AbstractDengue is one of the vector borne diseases that threatened human race. It is imperative to understand the transmission dynamics of dengue, so that proficient and useful control can be developed. In this paper, we formulated dynamic transmission of two strains super-infection dengue. We used next generation matrix to obtain the basic reproduction numbers$${\mathcal {R}}_1$$R1,$${\mathcal {R}}_2$$R2,$${\mathcal {R}}_{12}$$R12. The obtained basic reproduction numbers are then used to test for stabilities whenever$${\mathcal {R}}_1<1$$R1<1,$${\mathcal {R}}_2<1$$R2<1,$${\mathcal {R}}_{12}<1$$R12<1, disease free-equilibrium is globally asymptotically stable or otherwise unstable. We also carried out numerical simulation with the aid of python software. Our results reveal that decreasing the value of tansmission probability$$\alpha ,$$α,slows down the spread of the disease.
Plasma and Urine Free Glycosaminoglycans as Monitoring and Predictive Biomarkers in Metastatic Renal Cell Carcinoma: A Prospective Cohort Study
Authors: Gatto Francesco , Bratulic Sinisa , Jonasch Eric , Limeta Angelo , Maccari Francesca , Galeotti Fabio , Volpi Nicola , Lundstam Sven , Nielsen Jens , Stierner Ulrika 
Published: February 2023

PURPOSENo liquid biomarkers are approved in metastatic renal cell carcinoma (mRCC) despite the need to predict and monitor response noninvasively to tailor treatment choices. Urine and plasma free glycosaminoglycan profiles (GAGomes) are promising metabolic biomarkers in mRCC. The objective of this study was to explore if GAGomes could predict and monitor response in mRCC.PATIENTS AND METHODSWe enrolled a single-center prospective cohort of patients with mRCC elected for first-line therapy (ClinicalTrials.gov identifier: NCT02732665 ) plus three retrospective cohorts (ClinicalTrials.gov identifiers: NCT00715442 and NCT00126594 ) for external validation. Response was dichotomized as progressive disease (PD) versus non-PD every 8‐12 weeks. GAGomes were measured at treatment start, after 6-8 weeks, and every third month in a blinded laboratory. We correlated GAGomes with response and developed scores to classify PD versus non-PD, which were used to predict response at treatment start or after 6-8 weeks.RESULTSFifty patients with mRCC were prospectively included, and all received tyrosine kinase inhibitors (TKIs). PD correlated with alterations in 40% of GAGome features. We developed plasma, urine, and combined glycosaminoglycan progression scores that monitored PD at each response evaluation visit with the area under the receiving operating characteristic curve (AUC) of 0.93, 0.97, and 0.98, respectively. For internal validation, the scores predicted PD at treatment start with the AUC of 0.66, 0.68, and 0.74 and after 6-8 weeks with the AUC of 0.76, 0.66, and 0.75. For external validation, 70 patients with mRCC were retrospectively included and all received TKI-containing regimens. The plasma score predicted PD at treatment start with the AUC of 0.90 and at 6-8 weeks with the AUC of 0.89. The pooled sensitivity and specificity were 58% and 79% at treatment start. Limitations include the exploratory study design.CONCLUSIONGAGomes changed in association with mRCC response to TKIs and may provide biologic insights into mRCC mechanisms of response.