bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using intervention mapping to develop evidence-based toolkits that provide mental wellbeing support to workers and their managers whilst on long-term sick leave and following return-to-work
Authors: Varela-Mato Veronica , Blake Holly , Yarker Joanna , Godfree Kate , Daly Guy , Hassard Juliet , Meyer Caroline , Kershaw Charlotte , Marwaha Steven , Newman Kristina , Russell Sean , Thomson Louise , Munir Fehmidah 
Published: April 2023

Abstract

Background Managing long-term sickness absence is challenging in countries where employers and managers have the main responsibility to provide return to work support, particularly for workers with poor mental health. Whilst long-term sick leave and return to work frameworks and guidance exist for employers, there are currently no structured return to work protocols for employers or for their workers encompassing best practice strategies to support a positive and timely return to work outcome. Purpose To utilise the intervention mapping (IM) protocol as a framework to develop return to work toolkits that are underpinned by relevant behaviour change theory targeting mental health to promote a positive return to work experience for workers on long-term sick leave. Methods This paper provides a worked example of intervention mapping (IM) to develop an intervention through a six-step process to combine theory and evidence in the development of two toolkits – one designed for managers and one to be used by workers on long-term sick leave. As part of this process, collaborative planning techniques were used to develop the intervention. A planning group was set up, through which researchers would work alongside employer, worker, and mental health professional representatives to develop the toolkits. Additionally, feedback on the toolkits were sought from the target populations of workers and managers and from wider employer stakeholders (e.g., human resource specialists). The implementation and evaluation of the toolkits as a workplace intervention were also planned. Results Two toolkits were designed following the six steps of intervention mapping. Feedback from the planning group (n = 5; psychologist, psychiatrist, person with previous experience of poor mental health, employer and charity worker) and participants (n = 14; employers = 3, wellbeing director = 1; human resources = 2, managers = 2, employees with previous experience of poor mental health = 5) target populations indicated that the toolkits were acceptable and much needed. Conclusion Using IM allowed the development of an evidence-based practical intervention, whilst incorporating the views of all the impacted stakeholder groups. The feasibility and acceptability of the toolkits and their supporting intervention components, implementation process and methods of assessment will be evaluated in a feasibility pilot randomised controlled trial.
An Exploration/Investigation of General Practitioners’ and General Practice Nurses’ Opinions on Physical Activity Promotion to their Patients in Ireland
Authors: Kelliher Sean , Dowling Maura , Foley Sean Gerard , gupta ananya 
Published: April 2023

Abstract
Chronic disease rates are increasing globally, this is partially attributable to the global epidemic of physical inactivity. Physical activity promotion in primary care is regarded as the best approach for combating chronic disease. This study investigated the common beliefs and opinions among general practitioners and nurses on promoting physical activity to patients in Ireland. This research took a mixed-methods approach consisting of an online questionnaire (n=79) and semi-structured interviews (n=8). Lack of time, expertise, cohesiveness, referral pathways, and exercise professionals were the main barriers to physical activity promotion experienced. A small minority (7.6%) of participants were trained in exercise prescription, and 40.5% had knowledge of a local exercise professional. Furthermore, the research indicated that 70.2% of GPs and 86.4% of GP nurses did not provide an exercise referral. Physical activity promotion in primary care needs a cohesive approach. Involving an exercise professional is crucial to help facilitate to aid physical activity promotion.
Indicator-based Hydrological Resilience Framework for Urban Stormwater Management Systems
Authors: Valizadeh Nariman , Shamseldin Asaad Y. , Wotherspoon Liam 
Published: April 2023

Abstract
Urbanisation changes the nature of urban catchments by altering landcover, soil conditions and runoff storage capacity, resulting in increased runoff volume and peak flow due to disruption of the hydrological cycle. Contemporary stormwater management approaches such as Best Management Practice (BMP), Water Sensitive Design (WSD) and Sponge cities have introduced a new philosophy in stormwater management to reduce the impact of urbanization on surface runoff and improving the hydrological cycle in urban areas. These approaches mainly focus on hydrological mitigation by minimizing the impact of increasing runoff volume and peak flow. However, there are no robust approaches to evaluate the effect of changes in the hydrological characteristics of urban developed catchments on the resilience of stormwater management system to flooding. This paper introduces a novel framework to characterize the resilience of stormwater management systems in terms of the hydrological characteristics of an urban catchment. The framework is based on the differences in the peak flow and runoff volume of a catchment between the urbanized and greenfield conditions. A set of indices are defined to represent relationships between catchment performance capacities in stormwater management and design rainfall, culminating in the quantification of the hydrological resilience degree (\({R}_{hg}\)). The framework is tested in an urban catchment in Auckland, New Zealand to demonstrate the reduction in \({R}_{hg}\) as a function of rainfall depth and the influence of changes in hydrological characteristics. Different scenarios are analysed to demonstrate the effect of stormwater runoff control systems on resilience, with volume control devices providing the greatest increase in resilience. Mapping of the indices across sub-catchments provides a spatial representation of these changes and can be used as a tool in catchment management plans to optimize the hydrological mitigation and resilience of stormwater management systems.
Antioxidant, anti-inflammatory, antimicrobial and anticancer activities of the pods of green broad bean (Vicia faba L.), in vitro
Authors: Elbadrawy Elsayed , Mostafa Mona Y. 
Published: April 2023

Abstract

This study aimed to benefit from the pods’ byproduct of the broad bean (the outer shell). The chemical composition of the green pods was estimated. The methanolic extract of the broad bean pods (BBPs) activity was investigated in vitro as an antioxidant, anti-inflammatory, antimicrobial, and anticancer against prostate cancer (Pc3) and liver cancer (HepG2) cells. The findings revealed that BBPs have a high content of carbohydrates, fiber, protein, potassium, calcium, and magnesium. The total phenols and flavonoids of BBP extract were 286 mg GAE / g and 105 mg QE/g, respectively. The antioxidant activity of the BBP methanolic extract was measured by 1, 1- diphenyl-2-picryl hydrazyl (DPPH) assay. The highest value of DPPH scavenging activity (80.5%) was achieved by the extract concentrations of 1000 ug/ml. The concentrations of 500 and 250 ug/ml of BBP extract also showed high levels of DPPH scavenging activity (73.7 and 65.7%), respectively whereas the IC50 value was 87.35 ug/ml. The methanolic extract of BBP has an anti-inflammatory effect as it significantly reduces RBCs hemolysis. The maximum inhibition percentage reached 66.7% with a concentration of 1000 ug/ml. Regarding the antimicrobial activity, it was noticed that BBP extract prevented the growth of B. subtilis, Staph. Aureus, E. coli and Pseudomonas aeruginosa bacteria as well as the fungus Candida albicans. The effect of the methanolic extract of BBP against human hepatocarcinoma (HepG2) and prostate cancer (PC3) cells showed significant decreases in their cell viability in a concentration-dependent manner. It also caused significant changes in cell shape compared to the control.
Surgical outcomes of Gonioscopy-assisted Transluminal Trabeculotomy (GATT) in Primary and Secondary Open and Closed Angle Glaucoma
Authors: Yehezkeli Veronika , Ben-Haim Liron Naftali , Dar Nimrod , Sharon Tal , Harel Gal , Burgansky Zvia , Belkin Avner 
Published: April 2023

Abstract
Background
Gonioscopy assisted transluminal trabeculotomy (GATT) is a minimally invasive, ab interno conjunctival sparing glaucoma surgery aimed at the trabecular meshwork and the inner wall of Schlemm’s canal. The goal of this study is to report on the success of GATT in a large group of patients with a wide variety of open and closed angle glaucomas with or without cataract extraction, and to search for risk factors for failure.
Methods
A retrospective chart review of consecutive patients with primary or secondary open or closed angle glaucoma who underwent GATT, with or without concomitant phacoemulsification. Demographics, baseline clinical characteristics and postoperative outcomes were collected from patients' medical records. Primary outcomes were success and complication rates. IOP and the number of glaucoma medications were secondary outcome measures.
Results
GATT was performed on 127 eyes of 121 patients. Mean follow up was 8.7 ± 4.6 months (Range 3–23 months). Cumulative success at 6 months was 0.85 for GATT combined with cataract extraction, 0.92 for GATT alone, 0.9 for both POAG and SOAG and 0.73 for PACG. IOP decreased from a mean of 20.65 mmHg to 13 mmHg and 13.7 mmHg at 12 and 18 months, respectively. Medication decreased from a mean of 3.47 to 1.47 and 1.44 at 12 and 18 months, respectively. Twenty-five eyes (19.5%) were classified as failures. Pre-operative factors associated with an increased risk of failure requiring further surgery for pressure control were: preoperative maximal IOP (p = 0.001, OR: 1.177), post-operative IOP spike (p = 0.012, OR: 16.25), and prior incisional glaucoma surgery (p = 0.002, OR: 0.016).
Conclusion
GATT achieved good surgical success with good IOP and medication reduction across a wide range of glaucomas, in combination with lens extraction or as a standalone procedure. Gatt should be considered early in the treatment paradigm of medically uncontrolled glaucoma.
Inflammatory markers and increased carotid intimal thickness in asymptomatic growth hormone naive patients of Sheehan syndrome - A case control study
Authors: Naik Aasif Ahmad , mir Shahnaz Ahmad , kawa Iram Ashaq , Arshed Uzma , Khan Naseer Ahmad , Bhat Javid Ahmad , Hussain Altaf , Kousar Shazia , Amin Shazia , Sharma Puran , Singh Hardeep 
Published: April 2023

Abstract
Objective
The dyad of cardio-metabolic risk factors and endothelial dysfunction observed in hypopituitarism untreated for growth hormone deficiency (GHD), a characteristic of Sheehan's syndrome (SS), contributes to the increased cardiovascular mortality and morbidity. The elevated inflammatory markers reported in these patients along with conventional cardiovascular risk factors are pivotal contributors to coronary endothelial dysfunction and cardiovascular events. We aim to investigate the level of conventional cardiovascular risk factors, inflammatory markers and carotid artery Intima-Media Thickness (CIMT) in patients of SS compared to group of healthy women.
Methods
A total of 37 SS patients fulfilling the case definition for this study and same number (n = 37) healthy age, BMI and parity matched controls were recruited for the study. The participants underwent detailed clinical, biochemical, hormone analysis and measurement of Tumor necrosis factor-alpha (TNF-α) and Interleukin-6 (IL-6)levels. CIMT assessment was also done using high-resolution echo-colour Doppler system in both cases and controls.
Results
Patients with SS had significantly higher mean triglyceride, total cholesterol, low-density lipoprotein cholesterol and lower high-density cholesterol concentrations. The markers of inflammation including TNF-α and IL-6 levels were significantly higher (23.41 ± 10.97 vs. 20.05 ± 2.76pg/ml; p = 0.041) for TNF- α and (37.19 ± 5.38 vs. 32.08 ± 1.18pg/ml; p = 0.004) for IL-6, compared to healthy controls. Furthermore, mean carotid intima medial thickness in patients was significantly increased in comparison to healthy controls (0.71 ± 0.07 vs. 0.59 ± 0.05mm; p = 0.001).
Conclusion
Our study demonstrated that patients with SS have clustering of cardiovascular risk factors that may contribute to the increased risk for cardiovascular events.
Discovery of a new exotic cactus, Opuntia megapotamica Arechav. (Cactaceae) in South Africa using molecular data.
Authors: Mayonde Samalesu , Paterson Iain D , Byrne Marcus J 
Published: April 2023

Abstract
Some of the most dominant and widespread invasive species in South Africa are in the Cactaceae. The genus Opuntia contains almost half of the invasive cacti including the taxonomically challenging O. engelmannii Salm-Dyck ex. Engelm from North America. Three morphologically distinct varieties, O. engelmannii Limpopo, O. engelmannii Northern Cape and O. engelmannii Eastern Cape, were considered to be present in South Africa until recently. Confirming the identity of invasive O. engelmannii varieties is crucial for biological control using species-specific cochineals. To determine the identity of the varieties we inferred the phylogenetic relationships among them using sequence data of the intergenic trnL-F chloroplast region with representatives of morphologically similar cactus species from both North and South America obtained from GenBank. The cpDNA sequence dataset resulted in 429 characters containing seven parsimonious base pairs. Our phylogenetic analysis indicated that the Eastern Cape variety of O. engelmannii was closely matched with the South American Opuntias, with an identical cpDNA sequence matching O. megapotamica Arechav, while the other members of the O. engelmannii species complex, including the Limpopo and Northern Cape varieties, formed a monophyletic clade of the North American Opuntias. Our study confirms the presence of this cactus species outside its native range, which was previously misidentified in South Africa. More importantly, our study shows that exploration for potential cochineal biocontrol agents of the invasive O. megapotamica should be conducted in South America rather than North America, where previous potential biological control agents have been imported from.
Refractive changes in children in the Chicagoland area during the COVID-19 pandemic: a retrospective observational study
Authors: Kim Eugene , Stec Magdalena , Shaikh Noreen , Huang Jonathan , Ranaivo Hanta Ralay , Mets-Halgrimson Rebecca 
Published: April 2023

Abstract
Background
With remote learning during the COVID-19 pandemic came behavioral changes such as increased screen time and decreased outdoor time. This unprecedented situation grants itself to the study of the association of environmental factors on the worsening burden of myopia in children. Hence, this study aimed to investigate the association between behavioral changes caused by the COVID-19 pandemic and myopia progression in children.
Methods
This was a retrospective observational study performed among 2,064 patients ages 2–17 with cycloplegic refractions in the years 2019–2021 at a single tertiary children’s hospital. Exclusion criteria were a medical history of relevant connective tissue diseases, pseudophakia, and aphakia.
Results
The overall cohort (n = 2,064) had a mean spherical equivalent (SE) of 0.12 ± 3.70 D in 2019, -0.07 ± 3.95 D in 2020, and − 0.49 ± 3.85 D in 2021. The change in mean SE (0.42 D) from 2020–2021 was 2.2 times greater than the change (0.19 D) from 2019–2020 at baseline. In the cohort of return patients, there was a significant difference in myopic shift between years (F-ratio = 14.4, p < 0.00001), and a significant change from 2020 to 2021 (p = 0.00008) but not from 2019 to 2020. When observing the prevalence of myopia grouped by age, 8-year-old and 17-year-old patients had the greatest increase compared to baseline. When grouped by refractive error, low myopia children (-0.5 D to -3.00 D) displayed the greatest change in mean SE 2020–2021.
Conclusions
There was a substantial increase in myopia progression for children in the Chicagoland area after the period of COVID-19 changes. These findings may be explained by the behavioral changes of home confinement and online learning during the pandemic.
Towards a global biogeography of the glacier-fed stream benthic microbiome
Authors: Battin Tom , Ezzat Leïla , Peter Hannes , Bourquin Massimo , Michoud Grégoire , Fodelianakis Stilianos , Kohler Tyler , Lamy Thomas , Busi Susheel Bhanu , Daffonchio Daniele , Deluigi Nicola , De Staercke Vincent , Marasco Ramona , Pramateftaki Paraskevi , Schön Martina , Styllas Michail , Tolosano Matteo 
Published: April 2023

Abstract

Nearly 60% of the world’s glaciers are predicted to be lost by the end of the century because of global warming1. The impacts of this environmental change on the glacier-fed stream (GFS) ecosystems are profound, putting their ecological communities at risk2–4. Life in GFSs is dominated by benthic microbial biofilms, which regulate key ecosystem processes and form the basis of the food web5 . However, the biodiversity and biogeography of the biofilm microbiome of the world’s GFSs remain unknown, precluding a mechanistic understanding of its responses to glacier shrinkage. Here, applying metabarcoding to the benthic biofilm bacteria from 148 GFSs draining the world’s major mountain ranges, we unveil their global biodiversity and biogeography. We find that the global GFS benthic microbiome differs from other cryospheric microbiomes and is unexpectedly diverse. A large microbiome fraction (58% of the total amplicon sequence variants) is endemic to single mountain ranges, while 0.4% are disproportionately abundant and form a cosmopolitan core. These microbiome components have overlapping taxonomies, but their compositional turnover is differently shaped by dispersal limitation and environmental selection. Phylogenetic analyses relate prevalent clades to endemicity and microdiversity, the latter potentially buffering the GFS microbiome against climate-change impacts. Our global survey provides the basis for future climate-change microbiology studies6 on a rapidly changing ecosystem.
Improved Range of Motion and Decreased Complications After Total Knee Arthroplasty with Use of Plethy Recupe Remote Patient Monitoring – A Retrospective Study
Authors: Hui Timothy , Greene Hunter , Subramanian Subu , Ayalneh Bereket Sharew , Woldebirhan Yordanos , Sasaura Paul 
Published: April 2023

Abstract
Background
Home exercise plans are key to recovery from surgeries, but poor compliance limits the benefit. Though non-compliance can be up to 70% from previous research, digital health shows promise in improving compliance. This retrospective study compared pain, range of motion (ROM), and manipulation under anesthesia (MUA) complications after a total knee arthroplasty (TKA) from a clinic where one group used digital health and another did not. There is little previous research on this topic, so this study could show the benefits of digital health on joint replacement rehabilitation.
Methods
Patients were retrospectively selected from Summit Orthopedics TKA patients from 9/1/21 to 4/30/22. 41 patients used Recupe, a digital app that instructs and monitors home exercises along with live coaching with their TKA rehabillitation. 95 patients did not. Age, sex, and BMI between both groups were very similar.
Results
ROM improved significantly with the use of Recupe, improving to 120 degrees after 1 month - a key ROM level for functional use as indicated by studies. The non-recupe group improved to 112 degrees in the same timeframe.
The need for MUA was significantly better for the Recupe group, where 2% required MUA versus 5% for the other group, indicating a lower risk of major complications.
Pain averaged 2.34/10 for the Recupe group after 1 month versus 2.86/10 for the non-recupe group, though the decrease did not reach statistical significance.
The Recupe group performed their exercises an average of 5.1 times per week.
Conclusions
The Recupe group and the Non-Recupe group both attended medical and physical therapy visits, so the significant differences in results are likely due to non-adherence of HEP by the Non-Recupe group.
These results suggest that lengthened musculoskeletal recovery amongst workers may be due to non-adherence to their prescribed care plan, and that digital health may be an excellent way to improve their compliance.
Clinical Significance
Use of Recupe during rehabilitation after a Total Knee Arthroplasty results in significantly faster ROM improvement and significantly decreased risk of Manipulation Under Anesthesia. Pain was also decreased though not to statistical significance.
Detecting topics and polarity from Twitter: the ETSII-UPM case
Authors: Ruíz Almudena Sánchez , Galan Daniel , García-Beltrán Ángel , Rodríguez-Vidal Javier 
Published: April 2023

Abstract
Social networks have become a powerful communication tool, with millions of people exchanging information, opinions and experiences daily. Companies, organizations and even people have turned this tool into a marketing platform to position themselves and gain popularity. However, not only do companies present products or services to society, but society also provides feedback. This feedback has a significant impact as well. It is impossible to process all this vast information manually in time, but it is crucial. This information is precious even for governmental or state public entities such as universities. Potential future students will use social media to find out about the general feel of the institution. Therefore, this study presents a new dataset called CEIMaT2021, which compiles all the tweets in Spanish related to the Technical School of Industrial Engineering of the Universidad Politécnica de Madrid (ETSII-UPM). This dataset is designed for two of the main tasks of Online Reputation Management: (I) automatic detection of topics and (II) polarity. In addition, this study shows for these tasks that the SVM algorithm obtains a better performance for topic detection. Meanwhile, XGB obtains better results for polarity detection.