bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the impact of PSO, ABC, BFO and Cuckoo search optimization techniques on UPFC device for sustainable voltage stability margin improvement
Authors: Ikeli Ndubuisi Hyginus , Ashigwuike Chinemezu Evans , Alabi Ibitayo Isaac 
Published: May 2023

AbstractThis paper investigates the enhancement of voltage stability margin using Unified Power Flow Control (UPFC) device tuned with Particle Swarm Optimization (PSO), Artificial Bee Colony (ABC), Bacterial Foraging Optimization (BFO) and Cuckoo Search techniques (CS) on Nigerian 330 kV 56-bus practical network. In order to have a voltage stable power system, it is good to keep voltages within the acceptable limits. This is achieved using continuation power flow embedded in Power System Analysis Toolbox (PSAT). The optimal location and tuning of the UPFC device is determined using line stability index and the met-heuristics techniques. The effects of UPFC and the proposed optimizing techniques on voltage stability margin are examined. The results so obtained for tuning PSO, ABC, BFO and Cuckoo Search with UPFC device are compared to know the technique that yields the best loading parameter for Nigerian 56- bus power system for voltage stability margin enhancement. It is found that UPFC tuned with Cuckoo Search outperforms the other techniques in terms of the increased loading parameter of the Nigerian power system with margin improvement of 86.6%, 90% and 88.6% for Adiabor (Bus 45), Jalingo (Bus 34) and Jos (Bus 13). The tuned UPFC device has proved beyond reasonable doubt that it can improve voltage stability margin of the entire Nigerian 330 kV Network as envisaged from results before and after optimization.
Crinum jagus: antiproliferative studies of extracts on HepG2 cell line and in silico assessment of phytoconstituents as potential inhibitors of p53–mortalin interaction
Authors: Alawode Taye Temitope , Lajide Labunmi , Olaleye Mary , Owolabi Bodunde 
Published: May 2023

Abstract
Background
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and has a poor prognosis in black Africans. Traditional herbal practitioners in southwestern Nigeria use Crinum jagus (J. Thompson) Dandy for cancer treatment. This study screens methanol and ethyl acetate extracts of C. jagus leaves for activity against hepatocellular carcinoma (HepG2) cell line using the 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assay. The antiproliferative properties of the extracts were assessed by comparing their IC50 values with that of the standard drug, cisplatin.
The GC–MS technique was used to identify the phytoconstituents in the extracts. The drug-likeness of each identified phytoconstituents in the extracts was determined by following Lipinski’s rule of five. In addition, phytoconstituents having drug-like properties were screened as potential inhibitors of the p53–mortalin interaction by docking them against the mortalin residues 3N8E and 4KBO using Swissdock.

Results
For the antiproliferative study, the IC50 values obtained for cisplatin, methanol, and ethyl acetate extracts of leaves were 5 µg/mL, 5 µg/mL, and 70 µg/mL, respectively, indicating that the methanol extract and cisplatin possess comparable antiproliferative properties. Hexadecanoic acid, hexadecanoic acid methyl ester, tangeretin, galanthamine, and crinamine, which were part of the constituents identified in the leaves, possess drug-like properties and are known to show cytotoxic properties against several cancer cell lines. On docking with mortalin residue 3N8E, hexadecanoic acid and hexadecanoic acid methyl ester had comparable binding energy (− 8.21 kcal mol−1) with withaferin A and withanone (8.29 kcal mol−1 and 8.14 kcal mol−1). Hexadecanoic acid, hexadecanoic acid methyl ester, and galanthamine had binding energy of − 7.66, − 7.45, and − 7.47 kcal mol−1, respectively, with mortalin residue, 4KBO, comparable to values of − 7.68 and − 7.59 kcal mol−1 obtained for withaferin A and withanone, respectively.

Conclusion
The methanol extract of C. jagus leaves demonstrated remarkable antiproliferative activities against HepG2, justifying its use in traditional medicine for cancer treatment. The ethyl acetate and methanol extracts contain drug-like compounds with known cytotoxic properties against several cancer cell lines. Some of these compounds (hexadecanoic acid, hexadecanoic acid methyl ester, tangeretin, and galanthamine) are inhibitors of the p53–mortalin interaction.

Graphical Abstract
Surgery for mitral annular caseous calcification-related calcified amorphous tumor: a case report
Authors: Morisaki Akimasa , Takahashi Yosuke , Sakon Yoshito , Sumii Yosuke , Shibata Toshihiko 
Published: May 2023

Abstract
Background
A calcified amorphous tumor (a non-neoplastic tumor) with caseous calcification of the mitral annulus is a rare pathology that causes severe embolic events. We present a rare case of mitral valve surgery for a mitral annular caseous calcification-related calcified amorphous tumor found in cerebral infarction.

Case presentation
A 69-year-old man was diagnosed with a mitral valve calcified amorphous tumor with mitral annular caseous calcification found in cerebral infarction. He was admitted because of acute multiple embolic cerebral infarctions. A search for the embolic source through transesophageal echocardiography revealed a mitral valve tumor raised from the posterior mitral valve leaflet on the side of the left ventricle. Computed tomographic cardiac angiography revealed a calcified mitral valve tumor invading the posterior mitral valve annulus and left ventricular muscle. Intraoperative findings revealed a mitral annular calcification-related calcified amorphous tumor with caseous calcification of the posterior leaflet and annulus, which was suspected. Therefore, we performed radical debridement of the mitral annular calcification and bioprosthetic mitral valve replacement with patch repair of the posterior mitral valve annulus 2 weeks after the onset of cerebral infarction. The patient recovered well post operation, without any embolic events.

Conclusions
A calcified amorphous tumor with caseous mitral annulus calcification may be highly associated with embolic events. In this case, mitral valve replacement with annular patch repair may be a favorable procedure for preventing embolic events.
Thermal evolution and hydrocarbon generation history of the Weibei uplift in the Ordos Basin
Authors: Cui Junping , Ren Zhanli , Tao Hua , Qi Kai , Liu Hao , Chen Kezhang , Liu Jingjing 
Published: May 2023

The Weibei uplift in the Ordos Basin has a distinctive tectonic setting and intricate evolutionary history. Along these lines, we have used the stratum temperature, apatite fission track, and vitrinite reflectance data to restore the thermal and hydrocarbon generation histories of the Weibei uplift. The average value of the present geothermal gradient of the Weibei uplift was 27.9°C/km, and the heat flow was 64.9 mW/m2. The Weibei uplift exhibited a moderate geothermal field. Three uplift cooling events occurred in the Weibei uplift during the Mesozoic era: the late Jurassic-early Cretaceous (162–125 Ma), the late Cretaceous (105–65 Ma), and the Eocene-Oligocene (40–27 Ma). The uplift history indicates an early uplift in the south region and a late uplift in the later stage. The thermal evolution history simulation demonstrates that the lower Palaeozoic Ordovician source rocks began to enter the hydrocarbon generation threshold in the middle Permian-late Permian (270 Ma) era and joined the hydrocarbon generation peak in the early-middle Jurassic event (180 Ma). The upper Palaeozoic Carboniferous-Permian source rocks began to enter the hydrocarbon generation threshold in the later period of the middle Permian period (235 Ma). They joined the hydrocarbon generation peak in the late Jurassic-early Cretaceous period (150 Ma). In addition, Triassic source rocks entered the hydrocarbon generation threshold in the early Cretaceous era (135 Ma) and did not enter the hydrocarbon generation peak until now. The low geothermal gradient of the Weibei uplift in the Palaeozoic-early Mesozoic reached the maximum paleotemperature in the early Mesozoic era (100 Ma) because of tectonic thermal events. The highest geothermal gradient of the early Cretaceous reached 51.5°C/km. The peak period of the hydrocarbon generation of source rocks of the different horizons in the Weibei uplift was regulated by the geothermal field of the early Cretaceous event. Since the late Cretaceous period, the stratum has been uplifted and cooled rapidly, and the hydrocarbon generation process of the source rocks has ceased.
Development and Validation of a Prediction Model for Incident Hypothyroidism in a National Chronic Kidney Disease Cohort
Authors: Rhee Connie M , You Amy S , Narasaki Yoko , Brent Gregory A , Sim John J , Kovesdy Csaba P , Kalantar-Zadeh Kamyar , Nguyen Danh V 
Published: May 2023

Abstract

Context
Hypothyroidism is a common yet under-recognized condition in patients with chronic kidney disease (CKD), which may lead to end-organ complications if left untreated.

Objective
We developed a prediction tool to identify CKD patients at risk for incident hypothyroidism.

Methods
Among 15 642 patients with stages 4 to 5 CKD without evidence of pre-existing thyroid disease, we developed and validated a risk prediction tool for the development of incident hypothyroidism (defined as thyrotropin [TSH] &gt; 5.0 mIU/L) using the Optum Labs Data Warehouse, which contains de-identified administrative claims, including medical and pharmacy claims and enrollment records for commercial and Medicare Advantage enrollees as well as electronic health record data. Patients were divided into a two-thirds development set and a one-third validation set. Prediction models were developed using Cox models to estimate probability of incident hypothyroidism.

Results
There were 1650 (11%) cases of incident hypothyroidism during a median follow-up of 3.4 years. Characteristics associated with hypothyroidism included older age, White race, higher body mass index, low serum albumin, higher baseline TSH, hypertension, congestive heart failure, exposure to iodinated contrast via angiogram or computed tomography scan, and amiodarone use. Model discrimination was good with similar C-statistics in the development and validation datasets: 0.77 (95% CI 0.75-0.78) and 0.76 (95% CI 0.74-0.78), respectively. Model goodness-of-fit tests showed adequate fit in the overall cohort (P = .47) as well as in a subcohort of patients with stage 5 CKD (P = .33).

Conclusion
In a national cohort of CKD patients, we developed a clinical prediction tool identifying those at risk for incident hypothyroidism to inform prioritized screening, monitoring, and treatment in this population.
Van Wyk Grumbach Syndrome and Ovarian Hyperstimulation in Juvenile Primary Hypothyroidism: Lessons From a 30-Case Cohort
Authors: Kusuma Boddu Sirisha , Ayyavoo Ahila , Hebbal Nagarajappa Vani , Kalenahalli Kiran V , Muruda Shantakumar , Palany Raghupathy 
Published: May 2023

Abstract

Context
Prolonged hypothyroidism in children commonly causes short stature with delayed bone maturation, and delayed puberty. However, a paradoxical occurrence of peripheral precocious puberty and pituitary enlargement in chronically untreated juvenile hypothyroidism was first reported by Van Wyk and Grumbach in 1960.

Objective
To create increased awareness and a better understanding of this clinical entity among emergency room physicians, pediatricians, surgeons, gynecologists and oncologists.

Methods
Case records of children diagnosed with Van Wyk–Grumbach syndrome (VWGS) were analyzed retrospectively.

Results
Twenty-six girls and 4 boys were identified (2005-2020). All had profound primary hypothyroidism (total thyroxine [T4]: 2.5-33.5 nmol/L, thyrotropin: &gt; 75-3744 μIU/mL). Hypothyroidism was not the referral diagnosis in any of the girls. Among them, 17 were referred for precocious puberty, 5 with a diagnosis of pituitary tumor on magnetic resonance imaging, and others for acute surgical abdomen in 7 girls (painful abdominal mass—2, ovarian tumor—2, ovarian torsion—2, ruptured ovarian cyst—1), acute myelopathy in 1, and menorrhagia with headache in another. All girls were successfully managed with levothyroxine replacement alone, except for the 2 with ovarian torsion, who required surgery. Menstruation ceased promptly with T4 therapy in all girls, occurring at an age-appropriate later date. All boys had testicular enlargement at presentation that regressed partially after T4 treatment. Catch-up growth was remarkable during the first treatment year, but the final height was compromised in all.

Conclusion
Increased awareness of varied presentations of VWGS is vital among pediatricians to facilitate early diagnosis and targeted investigations, and to help in the initiation of the simple yet highly rewarding T4 replacement therapy to avoid all possible complications.
The quality of life of HIV positive Transgender and homosexual population in Karachi, Pakistan
Authors: Hussain Aneela , Rahim Anum , Rajput Fozia 
Published: May 2023

Objectives: To study the demographics and the quality of life of Transgenders and men who have sex with men (MSM) infected with Human Immunodeficiency Virus (HIV).
Methods: A Cross sectional study conducted from 2019 to 2021 in the Indus Hospital Karachi. A 30 minutes interview was conducted among HIV positive homosexual participants.
Results: Out of 100 patients enrolled 58% were transgender, 39% uneducated, 76% not supported financially by family, 20% reported hospital misconduct, 50% were commercial sex workers and 64% had anxiety. Our results also showed that increasing patient knowledge does not guarantee safe sex habits (p-value=0.82).
Conclusion: We found declining psycho-social wellbeing in this population. Education and family support may help establish a good standard of living in them. More studies are needed in the Pakistani transgender population in order to understand their needs better.
doi: https://doi.org/10.12669/pjms.39.4.6445
How to cite this: Hussain A, Rahim A, Fozia Rajput3. The quality of life of HIV positive Transgender and homosexual population in Karachi, Pakistan. Pak J Med Sci. 2023;39(4):---------. doi: https://doi.org/10.12669/pjms.39.4.6445
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Efficacy of Moringa oleifera Lam. extracts and Pediococcus pentosaceus, Lactobacillus acidophilus, Lactobacillus plantarum probiotic during starter period on growth performance of male broiler chicken
Authors: Karwanti Novita Wanda , Arumdani Dynda Febriana , Yulianto Andreas Berny , Marbun Tabita Dameria , Sherasiya Anjum , Al Arif Mohammad Anam , Lamid Mirni , Lokapirnasari Widya Paramita 
Published: May 2023

Background: Probiotics and medicinal plants have been used to support human and livestock health. This research aimed to evaluate the efficacy of Moringa oleifera Lam. leaf extract on the growth of P. pentosaceus, L.acidophilus and L. plantarum during starter period on nutrient intake, body weight gain, FCR and feed efficiency in broiler chicken. Methods: This study consisted of three sub studies:(1) Screening test for phytochemical compounds. The flavonoid test was conducted by Bate Smith-Metcalf and Wilstatter method. The Tannin test with Denis’ reagent. The saponin test was performed by the Forth method. Triterpenoid tests were performed by the Liebermann-Bouchard method and the alkaloids test was conducted by the method of Mayer, Bouchardat and Wagner. (2) evaluation of level M.oleifera extract, where each test tube was added with 1 mL of each isolate and incubated at 37°C. The growth of probiotic bacteria was calculated by using the TPC. (3) evaluation of probiotics and M. oleifera in vivo to prove growth performance. All results were analyzed by analysis of variance (ANOVA) then followed by the Duncan test. Results: (1)The phytochemical screening test of M. Oleifera extract showed the presence of flavonoids, saponins, tannins, triterpenoids and alkaloids; (2) in vitro evaluation of M. oleifera extract could increased the growth of bacteria probiotic (p <0.05); (3) The use of probiotics and M. oleifera extract could improve growth performance. The result of body weight, body weight gain, FCR and feed efficiency signifcantly differed (p<0.05), but there was no significant difference (p >0.05) on nutrient intake. Conclusions: The use of M.oleifera extract at doses of 0.1%, 0.2% and 0.3% increased the growth of P. pentosaceus, L. acidophilus and L. plantarum bacteria in vitro and the use of probiotics, M.oleifera extract and their combination by in vivo improved the growth performance on starter phase of broilers chicken.
Role of nutritional supplements on oral health in adults – A systematic review
Authors: Shodhan Shetty Aishwarya , Shenoy Ramya , Dasson Bajaj Parul , Rao Ashwini , KS Aparna , Pai Mithun , BR Avinash , Jodalli Praveen 
Published: May 2023

Purpose: The word ‘diet’ usually encompasses the consumption of food that includes all the necessary nutrients required for the optimal functioning of the body. Nutritional supplements hold a supreme position due to the demanding lifestyles or medical conditions in this current era. Although medical literature has sufficient evidence exploring the effect of nutrients on general health, this systematic review aimed at specifically evaluating the role of nutritional supplements on oral health in adults. Methods: PRISMA guidelines were followed in conducting this systematic review where four electronic databases including Scopus, PubMed, EMBASE, and Web of Science were reviewed. Based on the inclusion criteria, four studies exploring the effect of oral nutritional supplements on oral health among the adult population were included in this systematic review. Results: This review generated evidence suggesting a positive effect of nutritional supplements on oral health. These findings were depicted in the form of a reduction in plaque scores, probing depths, gingival inflammation, and greater improvement in periodontal healing among individuals with higher intakes of nutritional supplements within recommended doses. Conclusions: The systematic review outlines the positive impact of consuming nutritional supplements in the recommended dosage on oral health. Additionally, this review stresses the necessity for interventional studies to further investigate the effects of nutritional supplements on oral health, particularly in regard to periodontal healing. PROSPERO registration: CRD42021287797 (27/11/2021).
Implication of the 2014 World Health Organization Integrated Management of Childhood Illness Pneumonia Guidelines with and without pulse oximetry use in Malawi: A retrospective cohort study
Authors: Hooli Shubhada , Makwenda Charles , Lufesi Norman , Colbourn Tim , Mvalo Tisungane , McCollum Eric D. , King Carina 
Published: May 2023

Background: Under-5 pneumonia mortality remains high in low-income countries. In 2014 the World Health Organization (WHO) advised that children with chest indrawing pneumonia, but without danger signs or peripheral oxygen saturation (SpO2) < 90% be treated in the community, rather than hospitalized. In Malawi there is limited pulse oximetry availability. Methods: Secondary analysis of 13,413 under-5 pneumonia cases in Malawi. Pneumonia associated case fatality ratios (CFR) were calculated by disease severity under the assumptions of the 2005 and 2014 WHO Integrated Management of Childhood Illness (IMCI) guidelines, with and without pulse oximetry. We investigated if pulse oximetry readings were missing not at random (MNAR). Results: The CFR of patients classified as having non-severe pneumonia per the 2014 IMCI guidelines doubled under the assumption that pulse oximetry was not available (1.5% without pulse oximetry vs 0.7% with pulse oximetry, P<0.001). When 2014 IMCI guidelines were applied with pulse oximetry and a SpO2 < 90% as the threshold for referral and/or admission, the number of cases meeting hospitalization criteria decreased by 70.3%. Unrecorded pulse oximetry readings were MNAR with an adjusted odds for mortality of 4.9 (3.8, 6.3), similar to that of a SpO2 < 90%. Although fewer girls were hospitalized, female sex was an independent mortality risk factor. Conclusions: In Malawi, implementation of the 2014 WHO IMCI pneumonia guidelines, without pulse oximetry, will miss high risk cases. Alternatively, implementation of pulse oximetry may result in a large reduction in hospitalization rates without significantly increasing non-severe pneumonia associated CFR if the inability to obtain a pulse oximetry reading is considered a WHO danger sign.
Profunda femoris mycotic aneurysm as a complication of bacterial endocarditis: a case report and review of the literature
Authors: Dixon J , Mirtorabi N , Valenti D 
Published: May 2023

Profunda femoris aneurysms account for only 0.5% of all peripheral artery aneurysms. This case documents a profunda femoris mycotic aneurysm (MA) in a 47-year-old woman, three years post-treatment of bacterial endocarditis. The patient underwent an open surgical excision of the aneurysm with antibiotic cover and made a successful recovery. A literature review was carried out to look at other MA cases to summarise the most common presentations, infective agents and management strategies.
Integrating instructional design principles into surgical skills training models: an innovative approach
Authors: Rajaratnam V , Rahman NA , Dong C 
Published: May 2023

Objective Surgical training programmes are evolving from time-based to competency-based schedules, which define expected learning outcomes in surgical knowledge, clinical and technical skills according to training levels. This article aims to review current models in surgical skills acquisition and to propose an integrative process-driven, outcomes-based model for surgical skills acquisition and mastery. Design A literature review was conducted on the theories of motor skills acquisition using PubMed, Web of Science and Google Scholar from 2010 to February 2020. The review was limited to theories and models on surgical skills acquisition and mastery. Four models of surgical skills acquisition were included: Fitts and Posner’s three-stage model of motor skills acquisition, Bandura’s social learning theory, Ericsson’s deliberate practice model and Jeannerod’s motor simulation theory. These models are deficient in that there is no universally accessible opportunity to practise the surgical procedure outside of the operating theatre and without access to physical simulators. Results We propose an innovative model that allows deliberate practice of the procedure without the need for expensive physical simulators, and provides an on-demand, self-directed practice by the trainees to achieve the level of mastery. This new model, which incorporates motor imagery and mental practice, augmented by deliberate practice, will provide an alternative training path for expert performance in surgical procedures. Conclusions The innovative model provides a solution to the reduced opportunity for practice by surgical trainees to achieve mastery in surgical motor skills.