bluuebunny/crossref_metadata_2025_split huggingface dataset:
Custom-made acetabular revision arthroplasty for pelvic discontinuity: Can we handle the challenge?
Authors: Faraj Sayf , de Windt Tommy S. , van Hooff Miranda L. , van Hellemondt Gijs G. , Spruit Maarten 
Published: January 2023

Aims The aim of this study was to assess the clinical and radiological results of patients who were revised using a custom-made triflange acetabular component (CTAC) for component loosening and pelvic discontinuity (PD) after previous total hip arthroplasty (THA). Methods Data were extracted from a single centre prospective database of patients with PD who were treated with a CTAC. Patients were included if they had a follow-up of two years. The Hip Disability and Osteoarthritis Outcome Score (HOOS), modified Oxford Hip Score (mOHS), EurQol EuroQoL five-dimension three-level (EQ-5D-3L) utility, and Numeric Rating Scale (NRS), including visual analogue score (VAS) for pain, were gathered at baseline, and at one- and two-year follow-up. Reasons for revision, and radiological and clinical complications were registered. Trends over time are described and tested for significance and clinical relevance. Results A total of 18 females with 22 CTACs who had a mean age of 73.5 years (SD 7.7) were included. A significant improvement was found in HOOS (p < 0.0001), mOHS (p < 0.0001), EQ-5D-3L utility (p = 0.003), EQ-5D-3L NRS (p = 0.013), VAS pain rest (p = 0.008), and VAS pain activity (p < 0.0001) between baseline and final follow-up. Minimal clinically important improvement in mOHS and the HOOS Physical Function Short Form (HOOS-PS) was observed in 16 patients (73%) and 14 patients (64%), respectively. Definite healing of the PD was observed in 19 hips (86%). Complications included six cases with broken screws (27%), four cases (18%) with bony fractures, and one case (4.5%) with sciatic nerve paresthesia. One patient with concurrent bilateral PD had revision surgery due to recurrent dislocations. No revision surgery was performed for screw failure or implant breakage. Conclusion CTAC in patients with THA acetabular loosening and PD can result in stable constructs and significant improvement in functioning and health-related quality of life at two years' follow-up. Further follow-up is necessary to determine the mid- to long-term outcome. Cite this article: Bone Jt Open 2023;4(2):53–61.
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems
Authors: Barry Florent , Chai Feng , Chijcheapaza-Flores Henry , Garcia-Fernandez Maria José , Blanchemain Nicolas , Nicot Romain 
Published: January 2023

Objective
To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs).

Method
Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models.

Results
For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components.

Conclusions
MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.
Outcome of Concurrent Chemoradiation after Induction Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma - A Prospective Study among Patients Attending a Tertiary Care Center in Kerala, India
Authors: Preeya Vasanthakumary  , Binitha Tresa Thomas  , Devi Mohan  
Published: January 2023

BACKGROUND
Concurrent chemoradiation (CCRT) is the standard of care for locally advanced head and neck squamous cell carcinoma (LAHNSCC). In settings with considerable waiting period for radiation, institutional protocols advocate induction chemotherapy before CCRT. This study aimed to assess the outcome of concurrent chemoradiation after induction of chemotherapy among patients with LAHNSCC attending a tertiary care radiotherapy center in Kerala, India.
METHODS
Patients with non-metastatic LAHNSCC (stage 111 and 1V) with good performance score of 0-1 who received induction chemotherapy (with docetaxel 75mg/m2and cisplatin 75 mg/m2, day 1 and 5-fluorouracil 750 mg/m2, day 1 and 2 as infusion every 3 weeks for 3 cycles) followed by CCRT (with concurrent cisplatin 40 mg/m2 weekly) were selected for the study. CCRT was administered only to those patients who showed more than 30 % response to induction chemotherapy. They were followed up for 24 months. The primary end point was the clinical response assessed by ENT evaluation 8 weeks after the completion of CCRT.
RESULTS
117 patients with LAHNSCC were enrolled. Four patients (3.4 %) dropped out after induction therapy. Out of 113 patients who initiated concurrent chemo radiation, two patients (1.7 %) dropped out while on CCRT, two patients (1.7 %) were intolerant to CCRT and two patients (1.7 %) left soon after CCRT. 107 patients were available for follow up after treatment completion. Acute toxicities were noticed in 9 (7.7 %) while on induction treatment. Mucositis occurred in 1 (0.9 %), haematological toxicities in 4 (3.4 %), gastrointestinal toxicities in 2 (1.7 %) and fatigue and malaise in 2 (1.7 %). In patients who underwent concurrent chemo radiation, 53 (49.03 %) had acute mucosal, skin, GIT and haematological toxicities. On treatment completion, 82 patients (70.1 %) had complete response, 24 (20.5 %) had partial response and one (0.9 %) had stable disease. During the follow up period of 24 months, locoregional failure (relapse) was noted in 15 patients (12.8 %) while 61 patients (52.1 %) remained disease free. Organ preservation rate was 53.4 % for laryngeal primaries. 4 patients (3.4 %) developed distant metastases during the follow up.
CONCLUSIONS
Induction chemotherapy with docetaxel containing regime followed by concurrent chemoradiation was associated with good clinical response and acceptable toxicity profile.
Incidence of Hepatic Decompensation After Nucleos(t)ide Analog Withdrawal: Results From a Large, International, Multiethnic Cohort of Patients With Chronic Hepatitis B (RETRACT-B Study)
Authors: Hirode Grishma , Hansen Bettina E. , Chen Chien-Hung , Su Tung-Hung , Wong Grace , Seto Wai-Kay , Van Hees Stijn , Papatheodoridi Margarita , Brakenhoff Sylvia M. , Lens Sabela , Choi Hannah S.J. , Chien Rong-Nan , Feld Jordan J. , Forns Xavier , Sonneveld Milan J. , Papatheodoridis George V. , Vanwolleghem Thomas , Yuen Man-Fung , Chan Henry L.Y. , Kao Jia-Horng , Hsu Yao-Chun , Cornberg Markus , Jeng Wen-Juei , Janssen Harry L.A. ,   on behalf of the RETRACT-B study group
Published: January 2023

INTRODUCTION:
Despite improvements in the management of chronic hepatitis B (CHB), risk of cirrhosis and hepatocellular carcinoma remains. While hepatitis B surface antigen loss is the optimal end point, safe discontinuation of nucleos(t)ide analog (NA) therapy is controversial because of the possibility of severe or fatal reactivation flares.

METHODS:
This is a multicenter cohort study of virally suppressed, end-of-therapy (EOT) hepatitis B e antigen (HBeAg)-negative CHB patients who stopped NA therapy (n = 1,557). Survival analysis techniques were used to analyze off-therapy rates of hepatic decompensation and differences by patient characteristics. We also examined a subgroup of noncirrhotic patients with consolidation therapy of ≥12 months before cessation (n = 1,289). Hepatic decompensation was considered related to therapy cessation if diagnosed off therapy or within 6 months of starting retreatment.

RESULTS:
Among the total cohort (11.8% diagnosed with cirrhosis, 84.2% start-of-therapy HBeAg-negative), 20 developed hepatic decompensation after NA cessation; 10 events were among the subgroup. The cumulative incidence of hepatic decompensation at 60 months off therapy among the total cohort and subgroup was 1.8% and 1.1%, respectively. The hepatic decompensation rate was higher among patients with cirrhosis (hazard ratio [HR] 5.08, P < 0.001) and start-of-therapy HBeAg-positive patients (HR 5.23, P < 0.001). This association between start-of-therapy HBeAg status and hepatic decompensation remained significant even among the subgroup (HR 10.5, P < 0.001).

DISCUSSION:
Patients with cirrhosis and start-of-therapy HBeAg-positive patients should be carefully assessed before stopping NAs to prevent hepatic decompensation. Frequent monitoring of viral and host kinetics after cessation is crucial to determine patient outcome.
Effects of Jinkui Shenqi and Wuzi Yanzong pill on sperm motility and sperm DNA fragmentation rate in asthenospermia
Authors: Xu Liangliang , Xiao Chun Hong , Cao Hongyan , Yuan Jianfen , Wu Zhimei 
Published: January 2023

This study was designed to compare the effects of Jinkui Shenqi and Wuzi Yanzong pill on sperm motility and sperm DNA fragmentation rate in patients with asthenospermia. 130 cases were randomly divided into an observation and control group (n=65). The control group was treated with the Wuzi Yanzong pill while the observation group with the Jinkui Shenqi pill. The sperm motility parameters rate (PR), semen concentration, sperm motility, DFI and α-glucosidase, fructose, seminal plasma zinc (Zn), acid phosphatase (ACP) in seminal plasma biochemistry and other indexes of were observed. The biochemical indexes of seminal plasma of α-glucosidase, fructose, Zn, ACP in two groups were significantly (p<0.05) improved after treatment. Compared with the control group, the indexes of the observation group improved more obviously after treatment. Pearson correlation analysis of DFI and PR indexes in 130 patients before treatment showed that sperm DFI and PR percentage were negatively correlated in asthenospermia patients (r =-0.572, P<0.05). There was no significant difference in DFI, semen concentration, PR, and sperm motility between the two groups before treatment. The DFI, semen concentration, PR and sperm viability of the two groups showed a tendency to improve after treatment, and the effect of the observation group was less significant than that of the control group (p<0.05). Two groups of patients have completed treatment successfully, no adverse events occurred during treatment. Jinkui Shenqi pill can effectively treat asthenospermia, which can effectively improve the effect of sperm motility in patients. It has less adverse reactions, safe and reliable, and is worthy of promotion.
ADSORPSI ZAT WARNA RHODAMIN B DAN CONGO RED DENGAN SILIKA GEL DARI LIMBAH AMPAS TEBU (Saccharum officinarum)
Authors: Furozi Nur , Fajriyati Imelda , Artsanti Pedy , Krisdiyanto Didik 
Published: January 2023

Telah dilakukan sintesis silika gel dari ampas tebu (bagasse) yang berasal dari Pabrik gula madukismo Yogyakarta dan pabrik gula gondang klaten, menggunakan Natrium Hidroksida dan Asam Klorida sebagai pembentukan natrium silikat dan gel dengan metode sol-gel dilanjutkan karakterisasi dengan FT-IR dan GSA (Gas Sorption Analyzer). Tujuan penelitian ini adalah mengetahui efektifitas dsorbsi zat warna Rhodamin B dan Congo Red, kinetika adsorpsi dan kesetimbangan isotermis adsorpsi. Hasil adsorbsi FT-IR menunjukkan adanya gugus silanol pada bilangan gelombang 790,91 cm-1 dengan 50,1 % sebagai silika gel. Hasil adsorpsi GSA (Gas Sorption Analyzer) menghasilkan luas permukaan 43,422 m2/g, volume pori total 0,151 cc/g dan diameter 15,233 Amstrom. Kinetika adsorpsi Rhodamin B berlangsung pada reaksi orde satu dengan nilai R2 = 0,971 dan nilai K1 = 0,042. Kesetimbangan isotermis adsorpsi mengikuti model kesetimbangan Freundlich karena nilai R2 = 0,775 dan cenderung mendekati 1
Consciousness and the mind-brain-body-world relationship: towards a transdisciplinary and transcultural approach.
Authors: Facco Enrico 
Published: January 2023

The aim of this paper is to overview the main epistemological implications of the scientific approach to consciousness and the mind-brain relationship, undergone a lively debate in the past decades by strict materialist monist and dualist stances. Their limits, as well as the limits of reductionism and the shortcomings of classical Western thought, suggest the need for a broader perspective. Actually, a transdisciplinary approach helps overcoming the limits and incompleteness of single axiomatic disciplines. Likewise, a transcultural, metaphilosophical approach allows to understand key concepts and meanings common to different philosophies and cultures and properly face them beyond the multiplicity and ostensible oddity of forms. This approach seems to be appropriate in the study of consciousness and subjective phenomena, where the first-person perspective and the meaning of the experience are the condition sine qua non for their comprehension.
Unifying a posteriori error analysis of five piecewise quadratic discretisations for the biharmonic equation
Authors: Carstensen Carsten , Gräßle Benedikt , Nataraj Neela 
Published: January 2023

Abstract
An abstract property (H) is the key to a complete a priori error analysis in the (discrete) energy norm for several nonstandard finite element methods in the recent work [Lowest-order equivalent nonstandard finite element methods for biharmonic plates, Carstensen and Nataraj, M2AN, 2022]. This paper investigates the impact of (H) to the a posteriori error analysis and establishes known and novel explicit residualbased a posteriori error estimates. The abstract framework applies to Morley, two versions of discontinuous Galerkin, C
0 interior penalty, as well as weakly overpenalized symmetric interior penalty schemes for the biharmonic equation with a general source term in H
−2(Ω).
How Does Social Media Impact Consumers’ Sustainable Purchase Intention?
Authors: Arora Nilesh , Rana Meghna , Prashar Sanjeev 
Published: January 2023

Abstract
Expanding expenditures and emphasis on sustainable marketing necessitate additional research to comprehend how to effectively influence sustainable attitudes and behaviour, particularly in the under-researched realms of social media. The role of social media in creating and building attitudes towards sustainable purchasing is vastly underexplored. Based on social learning theory and the theory of planned behaviour, the present study has been endeavoured to investigate the factors that influence consumers’ sustainable purchase attitudes and intentions. With the data sets obtained from three hundred 50 respondents, structural equation modelling (SEM) was employed using AMOS 22.0. From the study findings, it is observed that social media usage, social influence, drive for environmental responsibility, and perceived trust in social media are the major antecedents of consumers’ sustainable purchasing attitudes, which in turn influence their sustainable purchase intentions. It is pertinent for prominent stakeholders, including governments and regulatory agencies, to employ the findings of this study while designing campaigns to encourage individuals to practise sustainable buying behaviour. Fostering sustainable buying behaviour could help mitigate the negative consequences of impulsive purchasing on human beings and the environment. Thus, deciphering the function of social media in promoting sustainable purchasing attitudes makes the current research novel and valuable.
Differences and Relationships Between Push-up and Sit-up Variations Among Male Law Enforcement Cadets
Authors: Lopes dos Santos Marcel , Thompson Megan , Dinyer-McNeely Taylor , Torrence Troy , Lockie Robert G. , Orr Robin M. , Dawes J. Jay 
Published: January 2023

Abstract
Lopes dos Santos, M, Thompson, M, Dinyer-McNeely, T, Torrence, T, Lockie, RG, Orr, RM, and Dawes, JJ. Differences and relationships between push-up and sit-up variations among male law enforcement cadets. J Strength Cond Res 37(9): 1865–1869, 2023—The purpose of this study was to explore variation-dependent differences in push-up and sit-up tests, as well as to identify the relationships between push-up and sit-up variations commonly performed among tactical personnel. Data from 41 (age = 21.1 ± 1.8 years, body mass = 89.5 ± 15.5 kg) male police cadets from one US-based training academy who performed the standard push-up (PUStandard), hand-release push-up (PUHand-release), standard sit-up (SUStandard), and hands behind the head sit-up (SUBehindHead) were examined. The maximum number of repetitions completed for each exercise was used for analyses with paired-samples t tests used to identify significant differences between outcome measures and effect sizes (ES) to determine change in magnitude. A significant difference, with a large ES, was found in the number of repetitions completed between the push-up variations (p < 0.001, ES = 0.75) and sit-up variations (p < 0.001, ES = 1.02). Performance in PUStandard was only able to explain 39% of the variation in PUHand-release (r = 0.62, r
2 = 0.39, p < 0.001), and performance in the SUStandard was only able to explain 29% of the variation in SUBehindHead (r = 0.54, r
2 = 0.29, p < 0.001). The current study suggests differences in performance capabilities may be dependent on the push-up and sit-up variations chosen for testing. Although it is still unclear whether one variation would be a better predictor of police work performance, agencies must give special attention to the overall construct validity of fitness tests for entry and retention of law enforcement officers.
Hippocampal Neuronal Activity Preceding Stimulus Predicts Later Memory Success
Authors: Jun Soyeon , Kim June Sic , Chung Chun Kee 
Published: January 2023

AbstractHippocampal neuronal activity at a time preceding stimulus onset affects episodic memory performance. We hypothesized that neuronal activity preceding an event supports successful memory formation; therefore, we explored whether a characterized encoding-associated brain activity, viz. the neuronal activity preceding a stimulus, predicts subsequent memory formation. To address this issue, we assessed the activity of single neurons recorded from the hippocampus in humans, while participants performed word memory tasks. Human hippocampal single-unit activity elicited by a fixation cue preceding words increased the firing rates (FRs) and predicted whether the words are recalled in a subsequent memory test; this indicated that successful memory formation in humans can be predicted by a preceding stimulus activity during encoding. However, the predictive effect of preceding stimulus activity did not occur during retrieval. These findings suggest that the preparative arrangement of brain activity before stimulus encoding improves subsequent memory performance.
ABCB‐mediated shootward auxin transport feeds into the root clock
Authors: Chen Jian , Hu Yangjie , Hao Pengchao , Tsering Tashi , Xia Jian , Zhang Yuqin , Roth Ohad , Njo Maria F , Sterck Lieven , Hu Yun , Zhao Yunde , Geelen Danny , Geisler Markus , Shani Eilon , Beeckman Tom , Vanneste Steffen 
Published: January 2023

AbstractAlthough strongly influenced by environmental conditions, lateral root (LR) positioning along the primary root appears to follow obediently an internal spacing mechanism dictated by auxin oscillations that prepattern the primary root, referred to as the root clock. Surprisingly, none of the hitherto characterized PIN‐ and ABCB‐type auxin transporters seem to be involved in this LR prepatterning mechanism. Here, we characterize ABCB15, 16, 17, 18, and 22 (ABCB15‐22) as novel auxin‐transporting ABCBs. Knock‐down and genome editing of this genetically linked group of ABCBs caused strongly reduced LR densities. These phenotypes were correlated with reduced amplitude, but not reduced frequency of the root clock oscillation. High‐resolution auxin transport assays and tissue‐specific silencing revealed contributions of ABCB15‐22 to shootward auxin transport in the lateral root cap (LRC) and epidermis, thereby explaining the reduced auxin oscillation. Jointly, these data support a model in which LRC‐derived auxin contributes to the root clock amplitude.
School Evaluation for Quality Improvement as The Gaze
Authors: Tumlovskaja Jelizaveta , Ruškus Jonas 
Published: January 2023

Within this paper, the authors examine the school performance quality assessment system in Lithuania from the standpoint of pedagogical staff who find themselves in the status of the assessed. The philosophical concept of The Gaze is used for the interpretation of the results of a quantitative and qualitative survey. The concept of the Gaze, as conceptualized by Sartre and Foucault, helps to understand the sense of tension between freedom and control as experienced by pedagogical staff who find themselves in the status of the assessed. The authors, by applying principles of phenomenological interpretative analysis and descriptive statistics, examine the process of school performance quality assessment as experienced by teachers. The informants identify themes such as stress, distress, work simulation, and creativity restrictions. The authors conclude that school performance quality assessments do emerge as the Gaze, and furthermore as a dilemma of communication known as the Double Bind, when at the same time contradictory objectives are held, and a regressive state of stress and distress is generated as a result. On the bases of results of their research, the authors suggest that the actual school performance quality assessment system in Lithuania must be fundamentally improved by applying the empowering consultancy approach, while measures of quality assessment should be focused on objective indicators of school performance quality assessment.
Induced color charge and quark propagation at Polyakov’s loop background
Authors: Skalozub V. , Turinov A. 
Published: January 2023

In quark­gluon plasma, the presence of the A0 (Polyakov loop (PL)) condensate results in the color Z(3) symmetry breaking and the Furry theorem violation. Due to these peculiarities, new phenomena ­ the induced color charges and other even­number diagram effects ­ are realized. Using the R̄ξ gauge, we ob­tain the ξ­-independent two­loop effective potential W (A0classical) expressed in terms of the PL. Its minimum position detects the value of the condensate. We calculate the one­loop tadpole diagram with one gluon line and the induced color charges Qind. Having these, we investigate the influence of the color charges on quark propagation and derive and partially investigate the contribution of them into the Schwinger­-Dyson equation for quarks. It is found that the presence of Qind effectively increases the strength of the A0 potential acting on colored particles in the plasma.
Semiclassical approach to perturbation theory
Authors: Turinov A. 
Published: January 2023

The problem of constructing approximate solution methods and finding convenient recurrent algorithms for the study of bound states of quantum mechanical equations is one of the central problems of modern theoretical physics. In this paper an explicit semiclassical treatment of perturbation theory for non-relativistic bound states based on ℏ–­expansions and corresponding quantization conditions of one­dimensional problems is developed. The wave functions are chosen in the same way as in the logarithmic perturbation theory. Due to the introduction of new quantization conditions, this method made it possible to obtain recurrent relations, which are convenient for finding the energy eigenvalues and wave functions of bound states in the case when nodes of wave functions are taken into account. Avoiding the flaws of the standard approach, the obtained recurrent relations have the same form both for the ground and perturbed states.