bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Implementation Of Scientific Approach Based On English Learning Strategy (SABELS) To The Students’ Ability In Reading Comprehension
Authors: Sormin Rizky Khairunnisa , Sari Ika Purnama , Purba Anita 
Published: August 2023

This research aims to apply The Scientific Approach-Based English Learning Strategy (SABELS) on the students’ ability in comprehending text fourth semester students of STIKOM Tunas Bangsa. This research is descriptive qualitative, because the researcher used descriptive method to analize the data and the data are in the form of word. This research conducted in STIKOM Tunas Bangsa Pematangsiantar. The researcher used three techniques to collecting the data. Those are observation, interview and study document. The researcher did two observations in class. The subject of the interview is the teacher as implementer the teaching learning process. The research findings are (1) the Implementation of the Scientific Approach in the Teaching of Reading Comprehension to the fourth semester students at STIKOM Tunas Bangsa was good, because was appropriate with the regulation, (2) in applying scientific approach, the teacher used five phase, those are observing, questioning, experimenting, associating, and communicating. The teacher used authentic assessment in the evaluation. Based on the second meeting, the English teacher uses writing test to assess the cognitive aspect of the students. Finally, by knowing the result, it is better if English teachers apply the SABELS to improve the students’ achievement.
EFFECTIVENESS OF DECOY WATER TREATMENT ON REACTIVATORS AT PT GOODYEAR INDONESIA Tbk
Authors: Niati Sri Murda , Akbar Guruh , Cahya Gemala 
Published: August 2023

PT Goodyear Indonesia Tbk is a tire manufacturing industry whose main need is the provision of water for steam boiler decoys. This water is obtained from groundwater and surface water such as river water which is then treated in a reactivator using one of the coagulants, namely PAC, so that impurities from river water can be removed, so the water is cleaner and can be used for steam boilers and does not interfere with a further decoy water treatment. This study aims to determine the effectiveness of water treatment in reactivators to be a reference for further treatment considerations at PT Goodyear Indonesia Tbk. The test result data showed the efficiency value between the inlet and outlet and compared it with the control limit set by the company. The efficiency test parameters consist of pH, conductivity, clarity measurement, and color measurement. Based on the results of efficiency calculations, several test parameters show that water treatment in reactivators at PT Goodyear Indonesia Tbk is still good and has a high-efficiency value.
Association between systemic treatment with immune checkpoint inhibitor therapy in renal cell carcinoma and reduced risk of brain metastasis development
Authors: Damante Mark , Huntoon Kristin , Gibbs David , Pezzutti Dante , Olencki Thomas , Elder J. Bradley 
Published: August 2023

OBJECTIVE
Immune checkpoint inhibitor (ICI) efficacy in the treatment of metastatic renal cell carcinoma (RCC) without brain metastases (BMs) is well established in several clinical trials; however, patients with BMs were typically excluded from these trials. Therefore, the efficacy of ICI in the treatment or prevention of BM remains unclear. The primary aim of the study was to address the efficacy of ICI in treatment of patients with RCC BMs compared with patients receiving targeted therapies. A secondary aim was to evaluate the risk of RCC BM development among patients who received ICI versus targeted therapies early in their treatment course.

METHODS
A retrospective single-center review between 2011 and 2018 identified 425 patients treated for metastatic RCC. The study group included patients who received ICI and/or targeted therapies during their disease. Data analyzed included demographic information, systemic treatments, overall survival from RCC diagnosis (OSRCC) and from BM diagnosis (OSBM), and BM development. Fisher’s exact test was used to evaluate the frequency of BM occurrence. Survival was assessed using Kaplan-Meier curves and log-rank tests.

RESULTS
Of the 425 patients, 125 received ICI and 300 were treated with molecular targeted agents only during their clinical course. BMs occurred in 113 (9.5%) of the 425 patients. Among patients with BMs, OSRCC was improved with the use of ICI (77.2 vs 25.2 months, p < 0.001), with 1-, 2-, and 5-year survival rates of 93.9%, 81.8%, and 62.6%, respectively. The use of ICI was associated with increased OSBM (21.7 vs 8.9 months, p = 0.001). The rate of BM development was lower when patients were treated with ICI (8/100 [8.0%]) compared with targeted therapy (47/267 [17.6%]) (OR 0.41, 95% CI 0.18–0.89; p = 0.021).

CONCLUSIONS
ICI was associated with improved OSRCC and OSBM in patients with BMs and decreased the probability of BM development in patients with metastatic RCC. Prospective trials are needed to further evaluate optimal use of ICI in treatment of RCC BMs.
Stereotactic radiosurgery for sarcoma metastases to the brain: a single-institution experience
Authors: Zamarud Aroosa , Park David J. , Dadey David Y. A. , Yoo Kelly H. , Marianayagam Neelan J. , Yener Ulas , Szalkowski Gregory Arthur , Pollom Erqi , Soltys Scott , Chang Steven D. , Meola Antonio 
Published: August 2023

OBJECTIVE
Brain metastases (BMs) secondary to sarcoma are rare, and their incidence ranges from 1% to 8% of all bone and soft tissue sarcomas. Although stereotactic radiosurgery (SRS) is widely used for BMs, only a few papers have reported on SRS for sarcoma metastasizing to the brain. The purpose of this study was to evaluate the safety and effectiveness of SRS for sarcoma BM.

METHODS
The authors retrospectively reviewed the clinical and radiological outcomes of patients with BM secondary to histopathologically confirmed sarcoma treated with SRS, either as primary treatment or as adjuvant therapy after surgery, at their institution between January 2005 and September 2022. They also compared the outcomes of patients with hemorrhagic lesions and of those without.

RESULTS
Twenty-three patients (9 females) with 150 BMs secondary to sarcoma were treated with CyberKnife SRS. Median age at the time of treatment was 48.22 years (range 4–76 years). The most common primary tumor sites were the heart, lungs, uterus, upper extremities, chest wall, and head and neck. The median Karnofsky Performance Status on presentation was 73.28 (range 40–100). Eight patients underwent SRS as a primary treatment and 15 as adjuvant therapy to the resection cavity. The median tumor volume was 24.1 cm3 (range 0.1–150.3 cm3), the median marginal dose was 24 Gy (range 18–30 Gy) delivered in a median of 1 fraction (range 1–5) to a median isodose line of 76%. The median follow-up was 8 months (range 2–40 months). Median progression-free survival and overall survival were 5.3 months (range 0.4–32 months) and 8.2 months (range 0.1–40), respectively. The 3-, 6-, and 12-month local tumor control (LTC) rates for all lesions were respectively 78%, 52%, and 30%. There were no radiation-induced adverse effects. LTC at the 3-, 6-, and 12-month follow-ups was better in patients without hemorrhagic lesions (100%, 70%, and 40%, respectively) than in those with hemorrhagic lesions (68%, 38%, and 23%, respectively).

CONCLUSIONS
SRS, both as a primary treatment and as adjuvant therapy to the resection cavity after surgery, is a safe and relatively effective treatment modality for sarcoma BMs. Nonhemorrhagic lesions show better LTC than hemorrhagic lesions. Larger studies aiming to validate these results are encouraged.
Survival and quality of life after CSF diversion in adult patients with leptomeningeal metastasis–associated hydrocephalus: a systematic review and meta-analysis
Authors: Dhaliwal Jasneet , Ruiz-Perez Michelle , Mihaela-Vasilica Anca , Chari Aswin , Hill Ciaran Scott , Thorne Lewis 
Published: August 2023

OBJECTIVE
Leptomeningeal metastasis (LM) is associated with altered CSF flow dynamics in 50%–70% of patients. Approximately 1%–5% of patients develop symptomatic LM-associated hydrocephalus (LM-H), which adversely impacts quality of life (QOL), functional status, and overall survival (OS). There is equipoise for CSF diversion procedures in LM-H. This systematic review and meta-analysis aimed to assess the effect of CSF diversion on OS and QOL in this context.

METHODS
This systematic review was conducted according to the PRISMA guidelines. PubMed/Medline, Embase, Web of Science, and Scopus were searched for articles that evaluated the role of CSF diversion for LM-H due to systemic cancer in adult patients. A meta-analysis was conducted using random effects models, with mean differences and 95% CIs reported. Bias was assessed using the Risk of Bias in Nonrandomized Studies of Interventions (ROBINS-I) tool.

RESULTS
Ten eligible studies with a total of 494 patients were included. Two studies reported multivariate HRs for median OS, suggesting no significant effect of shunting on OS (pooled HR 0.42, 95% CI 0.09–1.94, p = 0.27). A difference between preoperative and postoperative Karnofsky Performance Status of mean 17.6 points (95% CI 10.44–24.68, p < 0.0001) was calculated from 4 studies. Across all studies, a symptomatic improvement rate of 67%–100% was observed, with high rates of improvement for headaches and nausea and lower rates for cranial nerve palsies. Complication rates across 9 studies ranged from 0% to 21.1%.

CONCLUSIONS
Based on the present findings, shunting does not improve OS but does relieve symptoms, suggesting that individuals who exhibit certain symptoms should be considered for CSF diversion. The present findings prompt the generation of a standardized decision-making tool and a critical analysis of the individual patient risk-benefit ratio. Implementation of these will optimize surgical management of LM-H patients.
Preoperative frailty and 30-day mortality after resection of brain metastases: a multicenter surgical registry analysis of 11,038 patients
Authors: Skandalakis Georgios P. , Medani Khalid , Rumalla Kavelin , Roy Joanna M. , Segura Aaron , Zohdy Youssef M. , Kazim Syed Faraz , Schmidt Meic H. , Bowers Christian A. 
Published: August 2023

OBJECTIVE
Surgery plays a key role in the management of brain metastases. Stratifying surgical risk and individualizing treatment will help optimize outcomes because there is clinical equipoise between radiation and resection as treatment options for many patients. Here, the authors used a multicenter database to assess the prognostic utility of baseline frailty, calculated with the Risk Analysis Index (RAI), for prediction of mortality within 30 days after surgery for brain metastasis.

METHODS
The authors pooled patients who had been surgically treated for brain metastasis from the American College of Surgeons National Surgical Quality Improvement Program database (2012–2020). The authors studied the relationship between preoperative calculated RAI score and 30-day mortality after surgery for brain metastasis by using linear-by-linear proportional trend tests and binary logistic regression. The authors calculated C-statistics (with 95% CIs) in receiver operating characteristic (ROC) curve analysis to assess discriminative accuracy.

RESULTS
The authors identified 11,038 patients who underwent brain metastasis resection with a median (interquartile range) age of 62 (54–69) years. The authors categorized patients into four groups on the basis of RAI: robust (RAI 0–20), 8.1% of patients; normal (RAI 21–30), 9.2%; frail (RAI 31–40), 75%; and severely frail (RAI ≥ 41), 8.1%. The authors found a positive correlation between 30-day mortality and frailty. RAI demonstrated superior predictive discrimination for 30-day mortality as compared with the 5-factor modified frailty index (mFI-5) on ROC analysis (C-statistic 0.65, 95% CI 0.65–0.66).

CONCLUSIONS
The RAI frailty score accurately estimates 30-day mortality after brain metastasis resection and can be calculated online with an open-access software tool: https://nsgyfrailtyoutcomeslab.shinyapps.io/BrainMetsResection/. Accordingly, RAI can be utilized to measure surgical risk, guide treatment options, and optimize outcomes for patients with brain metastases. RAI has superior discrimination for predicting 30-day mortality compared with mFI-5.
Percutaneous transjugular approach without arterial monitoring for the treatment of a direct carotid-cavernous fistula with vascular Ehlers–Danlos syndrome: illustrative case
Authors: Uchiyama Naoyuki , Kawahara Yosuke , Uchida Wataru , Nitta Ayumu , Nohara Atsushi , Hayashi Yutaka 
Published: August 2023

BACKGROUND
Vascular Ehlers–Danlos syndrome (vEDS) because of COL3A1 mutations is a rare inherited collagen vascular disease associated with spontaneous arterial dissections, aneurysms, vessel rupture, and organ rupture. A direct carotid-cavernous fistula (CCF) is the most common central nervous system vascular anomaly in vEDS; however, its treatment is challenging due to extremely fragile arteries and veins.

OBSERVATIONS
A 22-year-old woman presented with pulsatile tinnitus and mild diplopia. CCF formation without trauma, cervical dissecting aneurysms, thin skin, and multiple ligament tears, as well as a genetic analysis, led to a diagnosis of vEDS. To minimize the risk of vascular injury in the thoracoperitoneal cavity, the internal jugular vein was directly punctured and the CCF was embolized transvenously using the triple-overlay road-mapping technique without arterial monitoring. The CCF was completely occluded, and the patient showed an excellent clinical course without neurological or vascular complications.

LESSONS
Physicians and neurosurgeons should consider vEDS when treating younger patients with spontaneous CCF without trauma and investigate the possibility of genetic abnormalities and systemic vascular pathology. Transvenous embolization of a CCF through the transjugular route using the triple-overlay road-mapping technique can minimize the risk of vascular injury in a patient with vEDS.
Symptomatic thoracic epidural lipomatosis with syringomyelia: illustrative case
Authors: Przepiorka Lukasz , Wójtowicz Katarzyna , Kunert Przemysław 
Published: August 2023

BACKGROUND
Spinal epidural lipomatosis is a rare but well-described disease. Here the authors present an extraordinary co-occurrence of spinal epidural lipomatosis with syringomyelia that did not improve after laminoplasty but required duroplasty as a definitive treatment.

OBSERVATIONS
This is the seventh case in the literature describing a co-occurrence of spinal epidural lipomatosis and syringomyelia. The pragmatic argument for a causative relationship between 2 phenomena is syrinxes reduction after surgery for spinal epidural lipomatosis. Additionally, duroplasty for spinal epidural lipomatosis in the setting of syringomyelia has not previously been reported. Duroplasty offers much better reconstruction of the subarachnoid space as compared with extradural decompression surgeries. It is one of the treatment options for spinal epidural lipomatosis. Last, most of the patients described in the literature with secondary syringomyelia were women with diabetes mellitus.

LESSONS
The co-occurrence of spinal epidural lipomatosis and syringomyelia is extremely rare. Neurological deficits in such cases respond well to surgical treatment. Accordingly, each case described in the literature resulted in syringomyelia reduction or resolution after surgery. Duroplasty may be necessary in selected cases of spinal epidural lipomatosis. Close follow-up and ongoing management of patients with epidural lipomatosis is therefore important.
PENGARUH CHANNEL YOUTUBE CNN INDONESIA “ PRESTASI ANAK PEMULUNG “ TERHADAP KEMAMPUAN MENGIDENTIFIKASI TEKS PERSUASI SISWA KELAS 8 SMP NEGERI 58 PALEMBANG
Authors: Adelia Piesesha Ayu , Hetilaniar Hetilaniar , Wandiyo Wandiyo 
Published: August 2023

The study discusses the influence of CNN Indonesia YouTube Channel “ Prestasi Anak Pemulung " on the ability to identify persuasive texts of 8th grade students of SMP Negeri 58 Palembang. This study was conducted to determine the influence of CNN Indonesia YouTube Channel "Prestasi Anak Pemulung" on the ability to identify persuasive texts of 8th grade students of SMP Negeri 58 Palembang. The reason for this research is because the researchers found several problems, including the lack of innovation in student learning, lack of interest in student learning, monotonous student learning methods and so on. This study uses a type of experimental quantitative research. This research method involves a true experiment by using 2 classes as a sample in the study with a design using 2 groups, namely the experimental group and the control group. Data collection techniques in this study include tests and documentation, with 2 times the pre-test and post-test data collection for 4 meetings. Analysis of usage data of CNN Indonesia YouTube channel "Prestasi Anak Pemulung" using SPSS analysis. The results of this research are expected to be useful for students to be able to learn in a more modern and fun way, for teachers to be able to conduct more elastic learning with the Times, and for future researchers to be inspired to provide other solutions to this problem.
Keywords: Influence, YouTube Channel, Persuasion Text, CNN Indonesia, identify
Historical Pathogen-Driven Selection May Contribute to Contemporary Ethnic Difference in Bladder Cancer Susceptibility
Authors: Meng Xiang-Yu , Wang Qiao-Li , Shi Ming-Jun , Zhang Hong-Yu 
Published: August 2023

BACKGROUND: The rationale for ethnic differences in bladder cancer (BCa) susceptibility is an important open question. In this study, we raised the hypothesis that the APOBEC3-rs1014971 variant associated with BCa risk and APOBEC-mutagenesis probably contribute to ethnic differences. METHODS: We calculated the ethnicity-stratified 5-year age-adjusted incidence rates of BCa using the US SEER database. We performed somatic mutational-signature analyses and compared the APOBEC-related mutational contribution across BCa tumors in patients of different ethnicities. We analyzed the allele frequency distribution of APOBEC3-related rs1014971 in contemporary populations of different ethnicities and in ancient human genomes. We also analyzed the natural selection profiles and ages of the investigated SNPs. RESULTS: We validated the ethnic difference in BCa risk using US SEER data, revealing Caucasians to be at >2-fold greater risk than Asians / Pacific islanders. In contemporary populations, we observed a coherent ethnic distribution in terms not only of the allele frequency of APOBEC3-related rs1014971, but also the mutational contribution of APOBEC-mediated mutagenesis in BCa tumors. Population genetics and ancient genome analyses further suggested that the diverse ethnic distribution of rs1014971 could be rooted in human evolution. CONCLUSIONS: It is possible that APOBEC3-related rs1014971 is involved in the different BCa incidence across ethnic groups, and this difference is potentially derived from human evolution. Our findings suggested an evolutionary link between contemporary population-level variations in malignancy susceptibility and pathogen-driven selection in the past, not unlike previously reported cases of certain autoimmune and metabolic disorders.
Sinusitis-Induced Orbital Apex Syndrome with Unusual Presentation of Facial Nerve Palsy In HIV-Positive Patient
Authors: Nathaniel Fernando , Hawari Irawaty , Firmansyah Yohanes , Wijaya Dean Ascha 
Published: August 2023

ABSTRACT Orbital Apex Syndrome (OAS) is a rare ophthalmological disorder characterized by complex symptoms originating from lesions at the orbital apex. Herein, we report a 60-year-old man with a history of diabetes mellitus and hypertension presented with a swollen left eye and sudden visual loss. He also had nasal symptoms before his admission. Treatment includes broad-spectrum antibiotics and antifungals with additional diabetes management and HIV evaluation. OAS, a severe and uncommon complication of a sinusitis infection, can present with diverse symptoms and cause nerve damage in the orbital apical area. The disease can be easily missed or overlooked when it exhibits atypical symptoms in its initial stages. It is crucial to be vigilant and consider the possibility of complications related to the orbital apex for early detection and appropriate treatment. Keywords: Facial Nerve Palsy, HIV, Orbital Apex Syndrome, Sinusitis
Hubungan Status Gizi dengan Perkembangan Anak Usia 3-5 Tahun di Puskesmas Citangkil II Kota Cilegon
Authors: Febriawati Herni , Trisonjaya Trisonjaya , Saputra Rangga , Ayuningtyas Nurry 
Published: August 2023

ABSTRACT Optimal development in toddlers needs to be supported by intake of nutrients and daily food in the right amount and good quality. Malnutrition in infancy can result in losses that cannot be repaired or replaced at a later date. To determine the relationship between nutritional status and motor development in children aged 3-5 years. Correlational quantitative research with cross sectional design. The number of samples is 110 children aged 3-5 years taken using purposive sampling technique. Results: The results of the univariate analysis showed that most of the children aged 3-5 years at the Citangkil II Health Center in Cilegon City had good nutritional status (72.6%) and most of them had development according to their age (61.8%). The results of the bivariate analysis obtained a p value: 0.000, so it was stated that nutritional status had a relationship with the development of children aged 3-5 years. There is a relationship between nutritional status and the development of children aged 3-5 years at Citangkil II Health Center, Cilegon City. Keywords: Toddler, Nutritional Status, Development ABSTRAK Perkembangan yang optimal pada balita perlu didukung oleh asupan zat gizi dan makanan sehari-hari dalam jumlah yang tepat dan kualitas yang baik. Kekurangan gizi pada masa balita dapat mengakibatkan kerugian yang tidak dapat diperbaiki atau digantikan di kemudian hari. Untuk mengetahui hubungan status gizi dengan perkembangan anak usia 3-5 tahun. Penelitian kuantitatif korelasional dengan desain cross sectional. Jumlah sampel adalah 110 anak usia 3-5 tahun diambil dengan menggunakan teknik purposive sampling. Hasil analisis univariat menunjukkan anak usia 3-5 tahun di Puskesmas Citangkil II Kota Cilegon sebagian besar memiliki status gizi baik (72,6%) dan sebagian besar memiliki perkembangan sesuai dengan umur (61,8%). Hasil analisis bivariat diperoleh p value: 0,000, sehingga dinyatakan bahwa status gizi memiliki hubungan dengan perkembangan anak usia 3-5 tahun. Ada hubungan antara statsus gizi dengan perkembangan anak usia 3-5 tahun di Puskesmas Citangkil II Kota Cilegon. Kata Kunci: Balita, Status Gizi, Perkembangan