bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the standardized amino acid digestibility of an alternative protein source with commercially available protein-based ingredients using the precision-fed cecectomized rooster assay
Authors: Oba Patrícia M , Utterback Pamela L , Longshaw Matt , Parsons Carl M , Swanson Kelly S 
Published: July 2023

Abstract
Using single-cell-based proteins in pet foods is of interest, but little testing has been done. Therefore, our objective was to determine the amino acid (AA) digestibilities, assess protein quality of a novel microbial protein (MP) (FeedKind), and compare it with other protein-based ingredients using the precision-fed cecectomized rooster assay. Test ingredients included: MP, chicken meal (CM), corn gluten meal (CGM), pea protein (PP), and black soldier fly larvae. Thirty cecectomized roosters (n = 6/ingredient) were randomly assigned to test ingredients. After 24 h of feed withdrawal, roosters were tube-fed 15 g test ingredient and 15 g corn, and then excreta were collected for 48 h. Endogenous AA corrections were made using additional roosters. Digestible indispensable AA score (DIAAS)-like values were calculated to determine protein quality according to Association of American Feed Control Officials (AAFCO), The European Pet Food Industry Federation, and National Research Council reference values for growing and adult dogs and cats. Data were analyzed using the Mixed Models procedure of SAS 9.4, with P ≤ 0.05 being significant. All reactive lysine:total lysine ratios, an indicator of heat damage, were higher than 0.9, except for CM (0.86). Digestibility of indispensable and dispensable AA were &gt;85% and &gt;80% for MP, respectively, with indispensable AA digestibilities being &gt;80% for all other ingredients. In general, CGM had the highest, while CM had the lowest AA digestibilities. Two exceptions were lysine and tryptophan. Lysine digestibility for MP was higher than that of all other ingredients, while tryptophan digestibility for MP was higher than that of CM, CGM, and PP. Threonine digestibility was highest for CGM and MP. Valine digestibility was highest for CGM, PP, and MP. DIAAS-like calculations identified limiting AA of each ingredient and depended on the reference used and life stage and species of animal. Using AAFCO guidelines, all DIAAS-like values for MP were &gt;100 suggesting that it could be used as the sole source of protein in adult dog and cat diets; only methionine had DIAAS-like values &lt;100 for growing kittens. For dogs, limiting AA was most commonly methionine, threonine, and tryptophan in the other protein sources. For cats, limiting AA was most commonly lysine and methionine. Lysine was severely limited in CGM across all life stages considered. Further research in dogs and cats is necessary, but our data suggest that the MP tested has high AA digestibilities and is a high-quality protein source that may be useful in pet foods.
State de-financialisation through incorporating local government bonds in the budgetary process in China
Authors: Li Zhenfa , Wu Fulong , Zhang Fangzhu 
Published: July 2023

Abstract
In China, state-led financialisation through local government financing platforms resulted in a surge in local government debt. To manage financial risk, the central state introduced local government bonds (LGBs) to replace the platforms as the main financing source for infrastructure investment. The issuance of LGBs is subject to a budgetary process. We argue that LGBs mark a turn to state de-financialisation, as the local state’s financial logic of maximising value extraction from the built environment is restricted by budgetary control. Through developing a database of LGB issuance in over 400 prefectural cities, this article reveals that local indebtedness determines the geographies of bond issuance, confirming the effect of the central state’s objective of restricting local government debt. The dynamics of state-led financialisation change from the inter-jurisdictional competition in infrastructure investment among local states through local government financing platforms to a hierarchical control of LGB issuance led by the central state using the budget. Our findings show that financial expansion may mean state de-financialisation and fiscal resources are not only used to promote state-led financialisation but also to enable state de-financialisation.
Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis
Authors: Ushimaru Richiro , Lyu Jiaqi , Abe Ikuro 
Published: July 2023

Abstract

Tetrapyrroles represent a unique class of natural products that possess diverse chemical architectures and exhibit a broad range of biological functions. Accordingly, they attract keen attention from the natural product community. Many metal-chelating tetrapyrroles serve as enzyme cofactors essential for life, while certain organisms produce metal-free porphyrin metabolites with biological activities potentially beneficial for the producing organisms and for human use. The unique properties of tetrapyrrole natural products derive from their extensively modified and highly conjugated macrocyclic core structures. Most of these various tetrapyrrole natural products biosynthetically originate from a branching point precursor, uroporphyrinogen III, which contains propionate and acetate side chains on its macrocycle. Over the past few decades, many modification enzymes with unique catalytic activities, and the diverse enzymatic chemistries employed to cleave the propionate side chains from the macrocycles, have been identified. In this review, we highlight the tetrapyrrole biosynthetic enzymes required for the propionate side chain removal processes and discuss their various chemical mechanisms.

One-Sentence Summary
This mini-review describes various enzymes involved in the propionate side chain cleavages during the biosynthesis of tetrapyrrole cofactors and secondary metabolites.
A tale of policy carve-outs and general exceptions: Eco Oro v Colombia as a case study
Authors: Ünüvar Güneş 
Published: July 2023

ABSTRACT
The Eco Oro v. Colombia Decision has garnered immediate public and academic attention and generated immense controversy. One of the reasons for its notoriety was the arbitral tribunal’s unconventional take on the general exceptions clause of the Canada–Colombia Free Trade Agreement and its contention that, even when a challenged measure fulfils the requirements of this exception, a host state’s duty to compensate remained. This conclusion has since been interpreted as an indication that, in spite of states’ attempts to carve certain regulatory and/or administrative measures motivated by public interest out of the protective scope of some recent international investment agreements (IIAs), such as environmental protection, arbitral tribunals continue to disregard these sensitivities. In light of this background, this article will focus on the parties’ arguments, the Tribunal’s analysis, as well as the interpretative implications of the Decision, focusing on indirect expropriation, the fair and equitable treatment, and the application of the general exception clause.
Inter- and intraspecific adaptations of pteridophyte leaf traits in limestone and non-limestone forests of monsoon tropical regions of southwest China
Authors: Phoutthavong Kittisack , Katabuchi Masatoshi , Nakamura Akihiro , Cheng Xiao , Cao Min 
Published: July 2023

Abstract
Plant species often show different taxonomic and functional characteristics between limestone forests (LFs) and non-limestone forests (NLFs) in tropical regions. Pteridophyte species are one of the major components in tropical rainforests; however, the morphological and physiological characteristics of pteridophytes occurring in LFs are poorly understood. We evaluated the differences in seven leaf functional traits between pteridophyte species in LFs and NLFs in southwest China. We measured leaf water content, morphological traits including leaf size, leaf thickness, stomatal length and stomatal density (SD), and physiological traits including stomatal conductance and photosynthetic rate from a total of 25 species. We found that pteridophytes had thicker and smaller leaves with lower SD and stomatal conductance in LFs compared with NLFs, probably reflecting their adaptations in water use strategies. These differences, however, became non-significant when phylogenetic relationships were taken into account, suggesting that phylogenetic conservatism shapes trait differences and ultimately species composition in LFs and NLFs. Some species that were commonly found in both LFs and NLFs exhibited intraspecific variation between forest types, with lower SD in LFs. Our findings suggest that only a handful of pteridophyte species can adapt to their water use strategies in both LFs and NLFs, and thus adaptative radiation is unlikely to occur.
Symbiosis between cyanobacteria and plants: from molecular studies to agronomic applications
Authors: Álvarez Consolación , Jiménez-Ríos Lucía , Iniesta-Pallarés Macarena , Jurado-Flores Ana , Molina-Heredia Fernando P , Ng Carl K Y , Mariscal Vicente 
Published: July 2023

Abstract
Nitrogen-fixing cyanobacteria from the order Nostocales are able to establish symbiotic relationships with diverse plant species. They are promiscuous symbionts, as the same strain of cyanobacterium is able to form symbiotic biological nitrogen-fixing relationships with different plants species. This review will focus on the different types of cyanobacterial–plant associations, both endophytic and epiphytic, and provide insights from a structural viewpoint, as well as our current understanding of the mechanisms involved in the symbiotic crosstalk. In all these symbioses, the benefit for the plant is clear; it obtains from the cyanobacterium fixed nitrogen and other bioactive compounds, such as phytohormones, polysaccharides, siderophores, or vitamins, leading to enhanced plant growth and productivity. Additionally, there is increasing use of different cyanobacterial species as bio-inoculants for biological nitrogen fixation to improve soil fertility and crop production, thus providing an eco-friendly, alternative, and sustainable approach to reduce the over-reliance on synthetic chemical fertilizers.
Limited-transpiration trait in response to high vapor pressure deficit from wild to cultivated species: study of the Lens genus
Authors: Rouichi Salma , Idrissi Omar , Sohail Quahir , Marrou Hélène , Sinclair Thomas R , Hejjaoui Kamal , Amri Moez , Ghanem Michel Edmond 
Published: July 2023

Abstract
Lentil (Lens culinaris Medik.) is commonly grown in drought-prone areas where terminal heat and drought are frequent. The limited-transpiration (TRlim) trait under high vapor pressure deficit (VPD) could be a way to conserve water and increase yield under water deficit conditions. The TRlim trait was examined in cultivated and wild lentil species together with its evolution throughout the breeding pipeline. Sixty-one accessions representing the six wild lentil species (L. orientalis, L. tomentosus, L. odemensis, L. lamottei, L. ervoides, and L. nigricans) and 13 interspecific advanced lines were evaluated in their transpiration response to high VPD. A large variation in transpiration rate (TR) response to increased VPD was recorded among wild lentil accessions, with 43 accessions exhibiting a breakpoint (BP) in their TR response to increasing VPD, with values ranging from 0.92 kPa to 3.38 kPa under greenhouse conditions. Ten genotypes for the interspecific advanced lines displayed a BP with an average of 1.95 kPa, much lower than previously reported for cultivated lentil. Results from field experiments suggest that the TRlim trait (BP=0.97 kPa) positively affected yield and yield-related parameters during the years with late-season water stress. The selection of TRlim genotypes for high VPD environments could improve lentil productivity in drought-prone areas.
Temperature regulation of auxin-related gene expression and its implications for plant growth
Authors: Bianchimano Luciana , De Luca María Belén , Borniego María Belén , Iglesias María José , Casal Jorge J 
Published: July 2023

AbstractTwenty-five years ago, a seminal paper demonstrated that warm temperatures increase auxin levels to promote hypocotyl growth in Arabidopsis thaliana. Here we highlight recent advances in auxin-mediated thermomorphogenesis and identify unanswered questions. In the warmth, PHYTOCHROME INTERACTING FACTOR 4 (PIF4) and PIF7 bind the YUCCA8 gene promoter and, in concert with histone modifications, enhance its expression to increase auxin synthesis in the cotyledons. Once transported to the hypocotyl, auxin promotes cell elongation. The meta-analysis of expression of auxin-related genes in seedlings exposed to temperatures ranging from cold to hot shows complex patterns of response. Changes in auxin only partially account for these responses. The expression of many SMALL AUXIN UP RNA (SAUR) genes reaches a maximum in the warmth, decreasing towards both temperature extremes in correlation with the rate of hypocotyl growth. Warm temperatures enhance primary root growth, the response requires auxin, and the hormone levels increase in the root tip but the impacts on cell division and cell expansion are not clear. A deeper understanding of auxin-mediated temperature control of plant architecture is necessary to face the challenge of global warming.
Hashimoto’s Encephalopathy with Use of Intravenous Immunoglobulin as First-Line Therapy
Authors: Barrett Laura D , Ballew Matthew , Ewers Evan 
Published: July 2023

ABSTRACT
Hashimoto’s encephalopathy is an uncommon cause of altered mental status in hospitalized patients and is challenging to diagnose, particularly in the presence of other psychiatric comorbidities. Corticosteroids are the primary treatment. Here, we present a patient with history of post-traumatic stress disorder and prior substance abuse admitted with profound altered mental status and agitation requiring admission to the intensive care unit and mechanical ventilation. He was treated with intravenous immunoglobulin (IVIG) instead of the standard steroid course because of concerns for worsening agitation. The patient had improvement with IVIG infusions, returned to a functional state, and has remained on IVIG therapy monthly since the initial episode without any disease recurrence.
Triple and quadruple black holes in the ASTRID simulation at z ∼ 2
Authors: Hoffman Calvin , Chen Nianyi , Di Matteo Tiziana , Ni Yueying , Bird Simeon , Croft Rupert , Loeb Abraham 
Published: July 2023

ABSTRACT
We use the ASTRID cosmological hydrodynamic simulation to investigate the properties and evolution of triple and quadruple massive black hole (MBH) systems at z = 2–3. Only a handful of MBH tuple systems have been detected to date. In ASTRID, we find 4 per cent of the $M_{\rm BH}\gt 10^7\, M_\odot$ are in tuples with $\Delta r_{\rm max} \lt 200\, {\rm kpc}$. The tuple systems span a range of separations with the majority of the observable AGN systems at Δr ∼ 50–100 kpc. They include some of the most massive BHs (up to $10^{10} \, M_\odot$) but with at least one of the components of $M_{\rm BH} \sim 10^7 \, {\rm M}_{\odot }$. Tuples’ host galaxies are typically massive with $M_* \sim 10^{10-11} \, M_\odot$. We find that $\gt 10~{{\ \rm per\ cent}}$ massive haloes with Mhalo &gt; 1013 M⊙ host MBH tuples. Following the subsequent interactions between MBHs in tuples, we found that in $\sim 5~{{\ \rm per\ cent}}$ of the triplets all three MBHs merge within a Gyr, and 15 per cent go through one merger. As a by-product of the complex multigalaxy interaction of these systems, we also find that up to $\sim 5~{{\ \rm per\ cent}}$ of tuples lead to runaway MBHs. In ASTRID, virtually all of the ultramassive black holes ($\gt 10^{10} \, M_\odot$) have undergone a triple quasar phase, while for BHs with $M_{\rm BH} \sim 10^9 \, M_\odot$, this fraction drops to 50 per cent.
The BACCO simulation project: biased tracers in real space
Authors: Zennaro Matteo , Angulo Raul E , Pellejero-Ibáñez Marcos , Stücker Jens , Contreras Sergio , Aricò Giovanni 
Published: July 2023

ABSTRACT
We present an emulator for the two-point clustering of biased tracers in real space. We construct this emulator using neural networks calibrated with more than 400 cosmological models in a 8D cosmological parameter space that includes massive neutrinos an dynamical dark energy. The properties of biased tracers are described via a Lagrangian perturbative bias expansion which is advected to Eulerian space using the displacement field of numerical simulations. The cosmology-dependence is captured thanks to a cosmology-rescaling algorithm. We show that our emulator is capable of describing the power spectrum of galaxy formation simulations for a sample mimicking that of a typical Emission-Line survey at z ∼ 1 with an accuracy of $1-2~{{\ \rm per\ cent}}$ up to non-linear scales $k\sim 0.7 h\, {\rm Mpc}^{-1}$.
Diffractive lensing of nano-Hertz gravitational waves emitted from supermassive binary black holes by intervening galaxies
Authors: Ma Hao , Lu Youjun , Chen Zhiwei , Chen Yunfeng 
Published: July 2023

ABSTRACT
Pulsar timing array (PTA) experiments are expected to detect nano-Hertz gravitational waves (GWs) emitted from individual inspiralling supermassive binary black holes (SMBBHs). The GW signals from a small fraction of these SMBBHs may be diffractively lensed by intervening galaxies. In this paper, we investigate the diffractive lensing effects on the continuous GW signals from the lensed SMBBHs and estimate the detectable number of such signals by PTAs, such as the Chinese PTA (CPTA) and the Square Kilometer Array (SKA) PTA. We find that the amplitude of the lensed GW signals may be only amplified by a factor of ∼1.01−1.14 ($16{-}84~{{\ \rm per\ cent}}$ range) and the phase of the signals may shift somewhat due to the lensing, significantly different from those strongly lensed high-frequency GW signals from compact binary mergers in the geometric optics. We estimate that $\sim 0.01~{{\ \rm per\ cent}}$ of all detected nano-Hertz GW signals from individual SMBBHs by future PTA experiments are lensed by foreground galaxies (i.e. up to ∼106 for CPTA and up to ∼289 for SKA-PTA). However, the lensed nano-Hertz GW signals are difficult to be distinguished from those without lensing by the PTA observations only. We further discuss the possibility about the identification of the lensed nano-Hertz GW signals from SMBBHs via the electromagnetic detection of their host galaxies or active galactic nuclei.
Feedback reshapes the baryon distribution within haloes, in halo outskirts, and beyond: the closure radius from dwarfs to massive clusters
Authors: Ayromlou Mohammadreza , Nelson Dylan , Pillepich Annalisa 
Published: July 2023

ABSTRACT
We explore three sets of cosmological hydrodynamical simulations, IllustrisTNG (TNG50, TNG100, and TNG300), EAGLE, and SIMBA, to investigate the physical processes impacting the distribution of baryons in and around haloes across an unprecedented mass range of $10^8\lt M_{\rm 200c}/\rm {{\rm M}_{\odot }}\lt 10^{15}$, from the halo centre out to scales as large as $30\, R_{\rm 200c}$. We demonstrate that baryonic feedback mechanisms significantly redistribute gas, lowering the baryon fractions inside haloes while simultaneously accumulating this material outside the virial radius. To understand this large-scale baryonic redistribution and identify the dominant physical processes responsible, we examine several variants of TNG that selectively exclude stellar and active galactic nucleus (AGN) feedback, cooling, and radiation. We find that heating from the UV background in low-mass haloes ($10^{8}\le {M_{\rm 200c}}/\rm {{\rm M}_{\odot }}\lt 10^{10}$), stellar feedback in intermediate-mass haloes ($10^{10}\le {M_{\rm 200c}}/\rm {{\rm M}_{\odot }}\lt 10^{12}$), and AGN feedback in groups ($10^{12}\le {M_{\rm 200c}}/\rm {{\rm M}_{\odot }}\lt 10^{14}$) are the dominant processes. Galaxy clusters ($M_{\rm 200c}/\rm {{\rm M}_{\odot }}\gt 10^{14}$) are the least influenced by these processes on large scales. We define a halo mass-dependent characteristic scale, the closure radius Rc, within which all baryons associated with haloes are found. For groups and clusters, we introduce a universal relation between this scale and the halo baryon fraction: Rc/R200c, 500c − 1 = β(z)(1 − fb(&lt; R200c, 500c)/fb, cosmic), where $\beta (z)=\alpha \, (1+z)^\gamma$, and α and γ are free parameters fit using the simulations. Accordingly, we predict that all baryons associated with observed X-ray haloes can be found within Rc ∼ 1.5–2.5R200c. Our results can be used to constrain theoretical models, particularly the physics of supernova and AGN feedback, as well as their interplay with environmental processes, through comparison with current and future X-ray and Sunyaev–Zel’dovich (SZ) observations.
Detailed equilibrium and dynamical tides: impact on circularization and synchronization in open clusters
Authors: Mirouh Giovanni M , Hendriks David D , Dykes Sophie , Moe Maxwell , Izzard Robert G 
Published: July 2023

ABSTRACT
Binary stars evolve into chemically peculiar objects and are a major driver of the galactic enrichment of heavy elements. During their evolution they undergo interactions, including tides, that circularize orbits and synchronize stellar spins, impacting both individual systems and stellar populations. Using Zahn’s tidal theory and mesa main-sequence model grids, we derive the governing parameters λlm and E2, and implement them in the new mint library of the stellar population code binary_c. Our mint equilibrium tides are two to five times more efficient than the ubiquitous bse prescriptions, while the radiative-tide efficiency drops sharply with increasing age. We also implement precise initial distributions based on bias-corrected observations. We assess the impact of tides and initial orbital-parameter distributions on circularization and synchronization in eight open clusters, comparing synthetic populations and observations through a bootstrapping method. We find that changing the tidal prescription yields no statistically significant improvement as both calculations typically lie within 0.5σ. The initial distribution, especially the primordial concentration of systems at log10(P/d) ≈ 0.8, e ≈ 0.05 dominates the statistics even when artificially increasing tidal strength. This confirms the inefficiency of tides on the main sequence and shows that constraining tidal-efficiency parameters using the e − log10(P/d) distribution alone is difficult or impossible. Orbital synchronization carries a more striking age-dependent signature of tidal interactions. In M35 we find twice as many synchronized rotators in our mint calculation as with bse. This measure of tidal efficiency is verifiable with combined measurements of orbital parameters and stellar spins.