bluuebunny/crossref_metadata_2025_split huggingface dataset:
A structural and phase influences the physico‐chemical, in vitro bioactivity of alumina‐zirconia nanoparticles loaded chitosan‐sodium alginate scaffold for biomedical applications
Authors: Shanmugam Balu Kolathupalayam , Arumugam Karthik , Srinivasan Surendhiran , Narayanasamy Sruthi , Saravanan Savitha 
Published: May 2023

AbstractPresently, alumina‐zirconia nanoparticles are prominently used in biomedical applications because of their valuable properties and augmented biological interactions. Amorphous (AZA) and tetragonal phase (AZT) nanoparticles are synthesized by spray pyrolysis. Three concentrations (10/15/20 mg) of synthesized alumina‐zirconia nanoparticles were mixed separately with 4 wt% of chitosan‐sodium alginate composite and developed as scaffolds using solvent casting. The physico‐chemical and in vitro biological properties of the prepared samples are evaluated using appropriate techniques. The physico‐chemical characteristics of AZT (tetragonal phase) nanoparticles and their scaffolds enhances in vitro biocompatibility, improve antibacterial activity against S. aureus and E. coli and also possess better in vitro cytotoxicity against human osteosarcoma (MG‐63) cells compare than amorphous nanoparticles (AZA) and their scaffolds. From the analysis, AZT nanoparticles and AZT scaffolds are fit for biomedical applications, including tissue engineering and nano theranostics.
A systematic review of opioid use and multimodal strategies in solid organ transplant recipients and living donors
Authors: Kutzler Heather L. , Lichvar Alicia B. , Quan David , Bowman Lyndsey J. , Diamond Adam , Doligalski Christina , Griffin Tina , Melaragno Jennifer , Sweiss Helen , Fleming James 
Published: May 2023

AbstractThe opioid epidemic has impacted analgesia in the postoperative period for solid organ transplant (SOT) donors and recipients. However, optimal pain management and opioid stewardship strategies have not been identified across this unique population. The purpose of this systematic review was to evaluate the impact of perioperative opioid use and to describe multimodal analgesic strategies to reduce opiate use in SOT recipients and living donors. A systematic review was conducted. Electronic searches were performed in Medline, Embase, Google Scholar, and Web of Science through December 31, 2021. Title and abstracts were screened. Relevant articles underwent full‐text review. Literature was separated into effects of opioid exposure on post‐transplant outcomes, recipient pain management strategies, and living donor pain management strategies. Search yielded 25,190 records, and 63 were ultimately included. The impact of opioid use on post‐transplant outcomes was assessed in 19 publications. The risk of graft loss in pretransplant opioid users was assessed in six reports and was found to be higher in the majority (66%) of publications. Opioid minimization strategies were reported in 20 studies in transplant recipients. Twenty‐four studies evaluated pain management strategies in living donors. Both populations used a combination of multimodal strategies to minimize opioid use throughout the hospitalization and on discharge. Opioids are associated with select negative outcomes in post‐transplant recipients. To minimize their use while also maintaining appropriate analgesia, multimodal pain regimens should be considered in SOT recipients and donors.
From bottle to bedside: Implementation considerations and antimicrobial stewardship considerations for bloodstream infection rapid diagnostic testing
Authors: Lapin Jonathan S. , Smith Richard D. , Hornback Krutika M. , Johnson J. Kristie , Claeys Kimberly C. 
Published: May 2023

AbstractAntimicrobial stewardship (AMS) programs have been quick to adopt novel molecular rapid diagnostic technologies (mRDTs) for bloodstream infections (BSIs) to improve antimicrobial management. As such, most of the literature demonstrating the clinical and economic benefits of mRDTs for BSI is in the presence of active AMS intervention. Leveraging mRDTs to improve antimicrobial therapy for BSI is increasingly integral to AMS program activities. This narrative review discusses available and future mRDTs, the relationship between the clinical microbiology laboratory and AMS programs, and practical considerations for optimizing the use of these tools within a health system. Antimicrobial stewardship programs must work closely with their clinical microbiology laboratories to ensure that mRDTs are used to their fullest benefit while remaining cognizant of their limitations. As more mRDT instruments and panels become available and AMS programs continue to expand, future efforts must consider the expansion beyond traditional settings of large academic medical centers and how combinations of tools can further improve patient care.
Natural products targeting signaling pathways associated with regulated cell death in gastric cancer: Recent advances and perspectives
Authors: Hu Qichao , Li Zhibei , Li Yubing , Deng Xinyu , Chen Yuan , Ma Xiao , Zeng Jinhao , Zhao Yanling 
Published: May 2023

AbstractGastric cancer (GC) is one of the most serious gastrointestinal malignancies with high morbidity and mortality. The complexity of GC process lies in the multi‐phenotypic linkage regulation, in which regulatory cell death (RCD) is the core link, which largely dominates the fate of GC cells and becomes a key determinant of GC development and prognosis. In recent years, increasing evidence has been reported that natural products can prevent and inhibit the development of GC by regulating RCDs, showing great therapeutic potential. In order to further clarify its key regulatory characteristics, this review focused on specific expressions of RCDs, combined with a variety of signaling pathways and their crosstalk characteristics, sorted out the key targets and action rules of natural products targeting RCD. It is highlighted that a variety of core biological pathways and core targets are involved in the decision of GC cell fate, including the PI3K/Akt signaling pathway, MAPK‐related signaling pathways, p53 signaling pathway, ER stress, Caspase‐8, gasdermin D (GSDMD), and so on. Moreover, natural products target the crosstalk of different RCDs by modulating above signaling pathways. Taken together, these findings suggest that targeting various RCDs in GC with natural products is a promising strategy, providing a reference for further clarifying the molecular mechanism of natural products treating GC, which warrants further investigations in this area.
IMC‐PID tuning method based on maximum sensitivity for uncertain multivariable systems
Authors: Chu Minghui 
Published: May 2023

SummaryA controller design method based on effective open‐loop transfer function (EOTF) and internal model control (IMC) is proposed for square multivariable systems with uncertain parameters. In this paper, two equivalent substitutions are used to deal with the multivariable system with uncertain parameters. In the first equivalent substitution, the EOTF method is used to solve the coupling problem of the system. In order to prevent the interval explosion problem of parameters, the affine algorithm is adopted in the decoupling process to determine the value region of system parameters. Then, the multivariable system with uncertain parameters is transformed into a set of single‐variable system with uncertain parameters. The second equivalent substitution is based on Kharitonov's theorem to process every single variable system with uncertain parameters and replace it by a set of boundary models. Meanwhile, in order to ensure that the tuning controller can not only make the system stable but also meet a certain degree of robustness, based on the idea of IMC, the maximum sensitivity is introduced to design the PID controller. Finally, numerical simulation results are given to verify the effectiveness of the proposed method.
Listening to the river: Representing non‐human needs and interests in debates about water governance and management
Authors: Strang Veronica 
Published: May 2023

AbstractThe social sciences and humanities have become increasingly critical of the anthropocentrism that supports exploitative relations with the non‐human domain. This shift in positionality recognises that non‐human beings and ecosystems are not humankind's passive subjects but the co‐creators of shared lifeworlds. A logical consequence is a greater appreciation of the rights and interests of non‐human beings and ecosystems, both in law and in the decision‐making processes that shape human‐environmental relations. This requires some form of pan‐species democracy that simultaneously respects biocultural diversity. Drawing on ethnographic research on the River Stour in Dorset, this paper considers how we might reimagine the notion of community to encompass human and non‐human inhabitants in river catchment areas. It considers what ‘speaking for the river’ would entail, and what a river might want to say. Employing anthropological approaches to art and material culture, examining ‘what things do’, and the multi‐species ethnography that illuminates interspecies relations, this requires an imaginative leap, not into faux animism, but into serious consideration of the river as an active partner in human‐non‐human relations. This requires us to understand the river's properties and behaviours, and how it acts both creatively and destructively upon all of the living kinds that depend upon it—and vice versa. What does a river need to ensure its own flourishing and that of its dependent communities? This paper considers how ‘listening to the river’ enables the representation of its needs and interests in decision‐making processes.
Crayfish assemblages correlate with dam‐induced effects on abiotic factors and predatory fish assemblages in Alabama streams
Authors: Barnett Zanethia C. , Ochs Clifford A. , Easson Gregory L. , Adams Susan B. 
Published: May 2023

AbstractStream faunal assemblage structure is tied closely to hydrology and associated physiochemical properties. By altering natural flows, dams and their impoundments impact faunal assemblages over long distances. Although numerous studies have assessed the effect of dams on stream fauna, information is lacking for crayfishes. In this study, we characterized the effects of relatively large storage dams on crayfish assemblage structures. Over 2 years, we sampled three impounded and two unimpounded streams across two drainages in Alabama, United States, to identify biotic and abiotic factors correlated with crayfish assemblage metrics. Compared to impounded streams, unimpounded streams had greater habitat complexity (e.g., aquatic vegetation and woody debris), fewer predator fishes, lower minimum temperatures, and more variable discharges. These characteristics correlated with a higher density and diversity of crayfishes and smaller adults in impounded compared to unimpounded streams. Crayfish species assemblages differed between drainages, as did the biotic and abiotic factors affecting crayfish assemblages in each drainage, suggesting that these factors were species‐specific in their effects. Additionally, analysis of land uses suggested that factors other than dams may have also contributed to the observed differences in assemblage structures between impounded and unimpounded streams. For instance, in the more urbanized drainage, crayfish assemblages were more similar between up and downstream sections in all streams, regardless of impoundment. Our results indicate that large dams alter stream crayfish assemblage structure, with potentially cascading effects in trophic and organic matter dynamics both up and downstream.
Reindeer control over shrubification in subarctic wetlands: spatial analysis based on unoccupied aerial vehicle imagery
Authors: Villoslada Miguel , Ylänne Henni , Juutinen Sari , Kolari Tiina H. M. , Korpelainen Pasi , Tahvanainen Teemu , Wolff Franziska , Kumpula Timo 
Published: May 2023

AbstractHerbivores can exert a controlling effect on the reproduction and growth of shrubs, thereby counter‐acting the climate‐driven encroachment of shrubs in the Arctic and the potential consequences. This control is particularly evident in the case of abundant herbivores, such as reindeer (Rangifer tarandus tarandus), whose grazing patterns are affected by management. Here, we tested how different reindeer grazing practices on the border between Finland and Norway impact the occurrence of willow (Salix spp.) dominated patches, their above‐ground biomass (AGB) and the ability of willows to form dense thickets. We used a combination of multispectral and RGB imagery obtained from unoccupied aerial vehicles field data and an ensemble of machine‐learning models, which allowed us to model the occurrence of plant community types (Overall accuracy = 0.80), AGB fractions (maximum R2 = 0.90) and topsoil moisture (maximum R2 = 0.89). With this combination of approaches, we show that willows are kept in a browsing‐trap under spring and early summer grazing by reindeer, growing mostly small and scattered in the landscape. In contrast, willows under the winter grazing regime formed dense stands, particularly within riparian areas. We confirm this pattern using a random forest willow habitat distribution model based on topographical parameters. The model shows that willow biomass correlated with parameters of optimal habitat quality only in the winter grazing regime and did not respond to the same parameters under spring and summer grazing of reindeer.
Properties of Nanocomposites Based on Platinum Nanoparticles Stabilized by Chitosan
Authors: Apryatina Kristina V. , Zuev Dmitry N. , Amarantov Sergey V. , Gusev Sergey A. , Zakharychev Evgeniy A. , Smirnova Larisa A. 
Published: May 2023

AbstractPlatinum nanoparticles were obtained chemically in acetic acid solutions of chitosan from the precursor H2PtCl6 using sodium borohydride as a reducing agent with simultaneous UV irradiation. The compositions were studied by SAXS, TEM, dynamic light scattering, FTIR‐spectroscopy, differential scanning calorimetry, dynamic mechanical analysis, and atomic force microscopy. Nanoparticles are characterized by a narrowly dispersed size distribution while the effect of the conformation of chitosan macromolecules on their characteristics is manifested. The SAXS method showed that in a chitosan solution with a semi‐flexible coil conformation of macromolecules, 96.8 % of the formed nanoparticles are characterized by an average radius of 1.4 nm. According to the TEM results, platinum nanoparticles are characterized by a crystal structure and a particle diameter of about 1.3–5.0 nm. A different picture is observed for platinum nanoparticles formed in chitosan with the rigid rod conformation of macromolecules – only 91 % of platinum nanoparticles had an average radius of 1.4 nm. The TEM method showed these nanoparticles turned out to be about 1 nm in size, and they did not crystallize, but remained amorphous. The introduction of platinum nanoparticles into the polysaccharide matrix significantly shifts the glass transition temperature of chitosan toward lower values by 20 and 10 °C respectively, and increases the tensile strength of the composites by 35 MPa.
A Highly Sensitive Toluene and Xylene QCM Nanosensor Using Nanoporous MIL‐101(Cr) as a Sensing Layer
Authors: Haghighi Elahe , Zeinali Sedigheh 
Published: May 2023

AbstractThis study reports a facile method to fabricate a metal‐organic framework (MOF) MIL‐101(Cr) based quartz crystal microbalance (QCM) for the detection of volatile organic compounds (VOCs) at room temperature. MIL‐101(Cr) as a novel superior material with an extremely large surface area of 2612 m2/g and pore volume of 1.26 cm3/g, can have higher adsorption capacity in comparison with zeolites, carbon nanotubes, and many porous polymers. It was chosen as a sensing thin film coated onto the surface of the QCM electrode by using the drop‐casting method. The synthesized MOF was characterized by scanning electron microscopy, Fourier‐transform infrared spectroscopy, X‐ray diffraction, and so on. The frequency of the crystal changes during the adsorption of gas molecules onto the MOF layer. Adsorption/desorption behaviors of toluene and o‐xylene vapors in different concentrations vs time are considered and sensing properties such as sensor response, response/recovery time, sensitivity, and limit of detection are measured. The sensor exhibits a short response/recovery time, as well as a fully reversible and repeatable sensor response that reflects the high stability of the sensor. The most prominent advantage of this research in comparison with other works is the high sensitivity of the sensor to o‐xylene and toluene with a sensitivity of 26.912 and 11.604 Hz/ppm and the very low detection limits of 1.960, 4.102 ppm for o‐xylene and toluene respectively which are very lower than the reported threshold limit values. π‐π stacking interaction between benzenedicarboxylate groups of MIL‐101(Cr) and aromatic rings may be the effective factor in selective detection among other analytes like methanol, ethanol, acetone, n‐hexane, dichloromethane, tetrahydrofuran (THF).
Investigation of N,N′‐Disulfopiperazinium Chlorometallates of Fe(III), Ni(II) and Co(II) as Hybrid Catalysts for the Synthesis of 1,2‐Dihydroquinazoline Derivatives
Authors: Kalita Sangeeta , Kashyap Niharika , Bora Debanga Bhusan , Das Sukanya , Borah Ruli 
Published: May 2023

AbstractThree organic salts of N,N′‐disulfopiperazinium cation with complex metal chloride anions of Fe(III), Ni(II) and Co(II) cations were developed as Brønsted‐Lewis acidic hybrid materials in solid state. Their structural compositions were established by FT‐IR, UV‐Visible, SEM, EDX, Powder XRD and Raman techniques. Thermogravimetric analyses showed removal of physisorbed water around 100 °C for Fe(III) salt in contrast to 150–170 °C for Ni(II) & Co(II) organic salts for strongly bound water molecules in highly crystalline state. Their Brønsted acidities were determined from comparative UV‐visible spectra of 4‐nitroaniline in water in presence of the halometallates while Lewis acidity strength was observed via FT‐IR spectra of these salts in presence of pyridine as probe molecule. The catalytic activity of these acidic organic salts was investigated for three‐component synthesis of 1,2‐dihydroquinazolines as recyclable heterogeneous catalysts.
A Promising Alternative for Aqueous Effluents Treatment: Modified Mesoporous Materials that are Photoactive under LED Visible Radiation.
Authors: Ochoa Rodríguez Pablo A. , Vaschetto Eliana G. , Casuscelli Sandra G. , Elías Verónica R. , Eimer Griselda A. 
Published: May 2023

AbstractTiO2 nanoparticles co‐doped with iron and carbon were tested in photocatalytic processes using visible radiation to degrade Acid Orange 7 and Paracetamol from aqueous solutions. In our previous reports, the mesoporosity and crystallinity of the samples were analyzed along with the calcination temperature effect. In this work, it was possible to verify the efficiency of a synergistic effect between dopants when a calcination at 150 °C was applied, favoring their localization in key sites of titania structure which improves the response under visible light. Such accomplishments could be also confirmed through photoluminescence analysis. Thus, the optimized solid showed an enhanced photocatalytic performance, reaching at only one hour of reaction, a complete degradation of both dye and drug while some intermediate species were reduced according to mineralization degree (around 80 %), and biodegradability achieved. Therefore, the proposed photocatalytic system presents potential as a previous step to a biological treatment for aqueous effluents.
Crystal Structure and Photochromic Properties of Two Complexes based on 1‐(4‐carboxybenzyl)‐4,4′‐bipyridinium Ligand
Authors: Yang Fengyi , Liu Na , Chen Jiali , Liu Jinjian 
Published: May 2023

AbstractSelecting different metal ions, two novel complexes {[Zn(BCbpy)(m‐BDC)(H2O)] ⋅ 2H2O}n (1) and [Co(H2O)6]0.5[Co0.5(BCbpy)(H2O)2](m‐BDC) ⋅ 3H2O ⋅ DMF (2) have been prepared and structurally characterized in the presence of the viologen ligand 1‐(4‐carboxybenzyl)‐4,4′‐bipyridinium (BCbpy) and 1,3‐benzenedicarboxylic acid (m‐H2BDC). The crystal structures and photochromic properties of two complexes have been investigated in this article. 1 possesses a two‐dimensional (2D) layered structure, while the structure of 2 is zero‐dimensional (0D). As expected, 1 and 2 were discovered to be photochromic accompanying electron transfer (ET). Interestingly, 1 can be dissolved in ethanol solution and deposited on filter paper, applied to a printing medium without ink.
Synthesis and Evaluation of 6‐Amino‐2‐styrylchromones as Anticancer Agents
Authors: Chen Ya‐Chen , Chu Yi‐Cheng , Li Cai‐Wei , Chen Jih‐Jung , Shih Tzenge‐Lien 
Published: May 2023

Abstract2‐Styrylchromones, a C‐2 styrene derivative of chromones, possess a broad spectrum of biological activity. However, 2‐styrylchromones are scarce in nature but not to mention the amino‐substituted styrylchromones. We have synthesized fourteen 6‐amino‐2‐styrylchromones and evaluated their anti‐cancer activity on human caucasian colon adenocarcinoma cells (HT‐29). 6‐Amino‐2‐styrylchromones and related derivatives have never been revealed their pharmacology profiles. Among the novel fourteen compounds, we reported that compound 9 h exhibited its potential with the comparable activity with 5‐flurouracil (5‐FU) as a referenced drug.
Green Synthesis of Metal Nanoparticles and Magnetic Nanocomposites for Adsorption, Desorption and Preconcentration of Pb(II)
Authors: Şahin Muradiye , Arslan Yasin 
Published: May 2023

AbstractSynthesis, characterization, Pb(II) adsorption, recovery, preconcentration and reusability of different nanoadsorbents were investigated in detail. With green synthesis, silver, iron oxide and iron copper nanoparticles (AgNPs, Fe3O4NPs and Fe/CuNPs) were synthesized and modified with chitosan and alginate natural polymers to form nanocomposite beads (Fe3O4‐CS, Fe3O4−AT, Fe/Cu−CS and Fe/Cu−AT). When the adsorption efficiencies of the seven synthesized nanoadsorbents from the aqueous medium were compared, it was seen that the magnetic bimetallic Fe/Cu−CS beads provided the highest adsorption with 100 % efficiency for Pb(II). The adsorption mechanism, effects of temperature, initial lead ion concentration and pH of the solution on the Pb(II) adsorption capacity of Fe/Cu−CS beads were investigated. The recovery studies have shown that Fe/Cu−CS beads have good adsorption/desorption performance around 90 % of desorption was achieved with 5 mM HNO3. These results show that Fe/Cu−CS beads have potential to be a promising material for adsorption, preconcentration and desorption of Pb(II) from aqueous solution.
Spatial Heterogeneity Directs Energy Dissipation in Condylar Fibrocartilage
Authors: Jiang Nan , Su Zhan , Sun Yixin , Ren Rong , Zhou Jiahao , Bi Ruiye , Zhu Songsong 
Published: May 2023

AbstractCondylar fibrocartilage with structural and compositional heterogeneity can efficiently orchestrate load‐bearing and energy dissipation, making the temporomandibular joint (TMJ) survive high occlusion loads for a prolonged lifetime. How the thin condylar fibrocartilage can achieve efficient energy dissipation to cushion enormous stresses remains an open question in biology and tissue engineering. Here, three distinct zones in the condylar fibrocartilage are identified by analyzing the components and structure from the macro‐and microscale to the nanoscale. Specific proteins are highly expressed in each zone related to its mechanics. The heterogeneity of condylar fibrocartilage can direct energy dissipation through the nano‐micron–macro gradient spatial scale, by atomic force microscope (AFM), nanoindentation, dynamic mechanical analyzer assay (DMA), and the corresponding energy dissipation mechanisms are exclusive for each distinct zone. This study reveals the significance of the heterogeneity of condylar fibrocartilage in mechanical behavior and provides new insights into the research methods for cartilage biomechanics and the design of energy‐dissipative materials.