bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distributed extended state observer design and output feedback anti‐disturbance control for nonlinear interconnected systems: A dynamic memory event‐triggered mechanism
Authors: Liu Yujie , Sun Haibin , Hou Linlin 
Published: August 2023

AbstractThis paper investigates a distributed extended state observer design and output feedback anti‐disturbance control for nonlinear interconnected systems (ISs) with multiple disturbances. First, a distributed extended state observer with a sparse observer communication network is established to estimate the system states and external disturbances. Then, an output feedback controller with a disturbance compensation (DC) item is designed, where a novel dynamic memory event‐triggered mechanism (DMETM) is proposed to save communication resources. Third, under the proposed controller, the closed‐loop signals are bounded and the system states and the estimation errors converge to zero. Additionally, the system outputs satisfy
performance. Finally, the simulation examples demonstrate the effectiveness of the DMETM in reducing the number of data transmissions compared to the dynamic event‐triggered mechanism (ETM).
Bootstrapping through discrete convolutional methods
Authors: Clark Jared M. , Warr Richard L. 
Published: August 2023

AbstractBootstrapping was designed to randomly resample data from a fixed sample using Monte Carlo techniques. However, the original sample itself defines a discrete distribution. Convolutional methods are well suited for discrete distributions, and we show the advantages of utilizing these techniques for bootstrapping. The discrete convolutional approach can provide exact numerical solutions for bootstrap quantities, or at least mathematical error bounds. In contrast, Monte Carlo bootstrap methods can only provide confidence intervals which converge slowly. Additionally, for some problems the computation time of the convolutional approach can be dramatically less than that of Monte Carlo resampling. This article provides several examples of bootstrapping using the proposed convolutional technique and compares the results to those of the Monte Carlo bootstrap, and to those of the competing saddlepoint method.
Adverse events related to accessory devices used during ureteroscopy: Findings from a 10‐year analysis of the Manufacturer and User Facility Device Experience (MAUDE) database
Authors: Juliebø‐Jones Patrick , Somani Bhaskar K. , Mykoniatis Ioannis , Hameed B. M. Zeeshan , Tzelves Lazaros , Æsøy Mathias S. , Gjengstø Peder , Moen Christian Arvei , Beisland Christian , Ulvik Øyvind 
Published: August 2023

AbstractObjectivesThe objective of this study was to evaluate adverse events and device events related to accessories used during ureteroscopy (URS).Materials and methodsAnalysis was performed of the records available in the Manufacturer and User Facility Device Experience database in the United States. Information was collected on characteristics of problem, timing, manufacturer verdict, successful completion of planned surgery, prolonged anaesthesia and injury to patient or staff.ResultsFive‐hundred seventy‐one events related to URS accessories were recorded. These were associated with the following devices: baskets (n = 347), access sheath (n = 86), guidewires (n = 78), balloon dilators (n = 27), ARDs (n = 17) and ureteral catheters (n = 16). Of the events, 12.7% resulted in patient injuries. Forty‐eight per cent of the events resulted in prolonged anaesthesia, but the planned surgery was successfully completed in 78.4% of all cases. Collectively, the manufacturers accepted responsibility due to actual device failure in only 0.5% of cases. Common problems for baskets were failure to deploy (39.5%) and complete detachment of basket head (34.6%) and partial breakage of the basket head (12.4%). Of the basket group, 4.3% required open or percutaneous surgery to remove stuck basket. Full break of the body of the access sheath occurred in 41.9% and complete ureteral avulsion in 3.5%. For balloon dilators, there was a burst in 37% of cases. Broken guidewires were associated with 11.5% requiring repeat intervention for retrieval and 6.4% required JJ stent due to perforation to the collecting system. No injuries to operating staff were recorded with accessory usage.ConclusionAccessories used during URS are fragile. Potential for serious injury does exist as a direct result of their use. Surgeons should familiarise themselves with these events and how they can be prevented.
Development of an educational low‐cost and ESP32‐based platform for fundamental physics
Authors: Cherifi Tarek , Salag Aicha , Kerrouchi Slimane 
Published: August 2023

AbstractThis paper describes how to implement a new low‐cost modular and open‐source didactic platform using an ESP32 board. The latter is designed to be used in undergraduate fundamental physics in the context of preparatory classes for engineering training. Thus, we intend to create a platform that will serve both teachers and students as a concrete means of carrying out and exploiting certain experimental processes by themselves. In this context, Android devices are used together with electronics development boards to realize this platform with reduced material costs available as open‐source hardware and software licenses. Tests and results are presented and the goal is then attempted. The results of this work will provide a new insight into the work carried out in this theme.
Initial refinement of data from video‐based single‐cell tracking
Authors: Korsnes Mónica Suárez , Korsnes Reinert 
Published: August 2023

AbstractBackgroundVideo recording of cells offers a straightforward way to gain valuable information from their response to treatments. An indispensable step in obtaining such information involves tracking individual cells from the recorded data. A subsequent step is reducing such data to represent essential biological information. This can help to compare various single‐cell tracking data yielding a novel source of information. The vast array of potential data sources highlights the significance of methodologies prioritizing simplicity, robustness, transparency, affordability, sensor independence, and freedom from reliance on specific software or online services.MethodsThe provided data presents single‐cell tracking of clonal (A549) cells as they grow in two‐dimensional (2D) monolayers over 94 hours, spanning several cell cycles. The cells are exposed to three different concentrations of yessotoxin (YTX). The data treatments showcase the parametrization of population growth curves, as well as other statistical descriptions. These include the temporal development of cell speed in family trees with and without cell death, correlations between sister cells, single‐cell average displacements, and the study of clustering tendencies.ResultsVarious statistics obtained from single‐cell tracking reveal patterns suitable for data compression and parametrization. These statistics encompass essential aspects such as cell division, movements, and mutual information between sister cells.ConclusionThis work presents practical examples that highlight the abundant potential information within large sets of single‐cell tracking data. Data reduction is crucial in the process of acquiring such information which can be relevant for phenotypic drug discovery and therapeutics, extending beyond standardized procedures. Conducting meaningful big data analysis typically necessitates a substantial amount of data, which can stem from standalone case studies as an initial foundation.
A real‐world study on the prevalence and risk factors of medication related osteonecrosis of the jaw in cancer patients with bone metastases treated with Denosumab
Authors: Bracchi Paola , Zecca Ernesto , Brunelli Cinzia , Miceli Rosalba , Tinè Gabriele , Maniezzo Massimo , Lo Dico Silvia , Caputo Mariangela , Shkodra Morena , Caraceni Augusto T. 
Published: August 2023

AbstractAimAssessing the incidence of Medication Related Osteonecrosis of the Jaw (MRONJ) in cancer patients with bone metastases receiving Denosumab (Dmab) and identifying potential risk factors.MethodsA retrospective observational study on consecutive cancer patients with bone metastases, who received at least one dose of Dmab and one follow‐up visit. MRONJ crude cumulative incidence (CCI) was estimated considering death without MRONJ as competing event. Multiple regression models were used to study the association between MRONJ incidence and potential risk factors: age, cancer diagnosis, previous bisphosphonates, dental treatments before starting Dmab, extraction or other dental treatment during Dmab, chemotherapy, hormone therapy, and antiangiogenic (AA) agents concurrent use.ResultsOn 780 patients included (median follow‐up 17 months), 54% and 18% had, respectively, breast and prostate cancer. The mean number of Dmab administration was 12. Fifty‐six patients developed MRONJ with a 24‐ and a 48‐month crude cumulative incidence of 5.7% (95% Cl: 4.2%–7.8%) and 9.8% (95% CI: 7.6%–12.7%), respectively. Higher MRONJ incidence was significantly associated with middle aged group (>56 and ≤73), both at univariate and multivariate analysis (p = 0.029 and 0.0106). Dental treatments (Hazard Ratio [HR] = 3.67; p = 0.0001), dental extractions (HR = 23.40; p < 0.0001), and previous BP administration (HR = 2.62; p = 0.0024) were significantly associated with higher MRONJ incidence at multivariate Cox analysis. Although not statistically significant, MRONJ incidence was lower for patients receiving chemotherapy or hormone therapy and higher for those receiving AAs.ConclusionsThe results confirm a clinically relevant incidence of Dmab‐induced MRONJ. Dental treatments, especially extraction, during and before Dmab, constitute a serious risk factor. The role of AA concurrent administration deserves further investigations.
Oral uracil–tegafur compared with intravenous chemotherapy as adjuvant therapy for resected early‐stage non‐small cell lung cancer patients
Authors: Liang Sheng‐Kai , Wu Chang‐Wei , Chang Ching‐I , Keng Li‐Ta , Lee Meng‐Rui , Wang Jann‐Yuan , Ko Jen‐Chung , Liao Wei‐Yu , Chen Kuan‐Yu , Ho Chao‐Chi , Shih Jin‐Yuan , Yu Chong‐Jen 
Published: August 2023

AbstractBackgroundStudies comparing the effectiveness of either adjuvant oral uracil‐tegafur (UFT) or intravenous chemotherapy on early‐stage (stage I and II) non‐small cell lung cancer (NSCLC) patients treated with complete surgical treatment remain limited.MethodsFrom January 2011 to December 2017, patients with early‐stage NSCLC (defined as tumor size >3 cm without mediastinal lymph node involvement or any distant metastasis) receiving either adjuvant oral UFT or intravenous chemotherapy after surgical resection were identified from the Taiwan Cancer Registry. Overall survival (OS) and relapse‐free survival (RFS) were the primary and secondary outcomes, respectively. Propensity matching was used for controlling confounders.ResultsA total of 840 patients receiving adjuvant therapy after surgery (including 595 oral UFT and 245 intravenous chemotherapy) were enrolled. Before matching, patients using oral UFT had significantly longer OS (HR: 0.69, 95% CI: 0.49–0.98, p = 0.0387) and RFS (HR: 0.79, 95% CI: 0.61–0.97, p = 0.0392) than those with intravenous chemotherapy. A matched cohort of 352 patients was created using 1:1 propensity score‐matching. In the Cox regression analysis, the UFT and the matched chemotherapy groups had similar OS (HR: 0.80, 95% CI: 0.48–1.32, p = 0.3753) and RFS (HR: 0.98, 95% CI: 0.72–1.34, p = 0.9149). Among subgroup analysis, oral UFT use was associated with longer RFS among the subgroups of non‐drinker (HR: 0.66, 95% CI: 0.34–0.99, p = 0.0478) and patients with stage IB disease (HR: 0.67, 95% CI: 0.42–0.97, p = 0.0341).ConclusionsThis population‐based study in the real‐world setting of Taiwan demonstrates comparable effectiveness between oral UFT and intravenous chemotherapy in terms of clinical outcomes for early‐stage NSCLC patients after surgery.
The development of a research‐led approach to train new research supervisors for psychotherapy and counselling psychology doctoral programmes
Authors: McBeath Alistair , Bager‐Charleson Sofie 
Published: August 2023

AbstractThe origins and development of a bespoke training programme for research supervisors for psychotherapy and counselling doctoral programmes are outlined with reference to a new research‐led conceptual model of research supervision called the 3Cs relational model of research supervision. Some examples of earlier conceptual models of research supervision are given as well as details of a nationwide research supervision programme. It is argued that psychotherapy and counselling psychology are such specialist areas that a bespoke research supervision teaching programme is required. The development and content of the programme is described with a strong emphasis on the creation of, as well as the acquisition of, knowledge. There was confirmation of the pedagogic validity of the 3Cs relational model of supervision. The need for research supervisors to embrace cultural competence is underlined.
A heart valve dedicated for aortic regurgitation: Review of technology and early clinical experience with the transfemoral Trilogy system
Authors: Baumbach Andreas , Patel Kush P. , Kennon Simon , Ozkor Mick , Mathur Anthony , Huerta Frank de la , Tamm Alexander R. 
Published: August 2023

AbstractAortic regurgitation (AR) is associated with morbidity and premature mortality. Surgical aortic valve replacement is not an option for many patients due to an adverse surgical risk profile, whilst transcatheter aortic valve implantation with most available prostheses has demonstrated suboptimal implantation success and outcomes. The JenaValve Trilogy™ system provides an attractive solution for such patients as it utilizes clips that directly attach onto the native valve leaflets to anchor. Initially designed for transapical delivery, the current transfemoral delivery system is under investigation in the United States and approved for aortic stenosis and regurgitation in Europe. We present an expert review on the technical aspects of the Trilogy system, provide a guide for implantation, discuss the available evidence for the technology and provide illustrative case examples.
In Situ Ultrasonic Measurements as a Tool to Characterize the Stages of the Zeolite A Crystallization Process
Authors: Baser Hasan , Selvam Thangaraj , Schwieger Wilhelm , Hartmann Martin 
Published: August 2023

AbstractZeolite A (LTA) was synthesized at 80 °C under hydrothermal conditions from a gel with the molar composition of 2.5 Na2O : 2 SiO2 : Al2O3 : 80 H2O. In the present study, we report the use of home‐made ultrasound devices as a real‐time, in situ diagnostic tool for monitoring the progress of zeolite formation. In addition, the specific aim of this study was to show that the measured ultrasound parameters – ultrasonic (US) velocity and attenuation – simultaneously provide independent information about the changes in the liquid and solid phase, respectively, during the crystallization process. Both views are necessary for extracting kinetic data about the zeolite crystallization processes and allow elucidating the different stages of zeolite LTA formation process. The obtained in situ US data were compared with conventional ex situ powder X‐ray diffraction measurements following the formation of zeolite LTA from dense gels. The results demonstrate that a good correlation exists between the crystallization progress of zeolite LTA in terms of crystallinity changes and the ultrasonic attenuation and velocity.
Seed pelleting and storage effects on germination of Pennycress (Thlaspi arvense L.)
Authors: Koirala Nasib , Barker David J. , Gesch Russ W. , Heller Nicholas J. , Hard Alexander W. , Wells Samantha S. , Phippen Winthrop B. , Lindsey Alexander J. 
Published: August 2023

AbstractPennycress (Thlaspi arvense L.) is an emerging bioenergy oilseed crop of interest to farmers in the Upper Midwestern United States. Improved lines with beneficial agronomic traits are being developed, including lines with reduced silicle shattering and altered seed coat characteristics, though planting and establishment is still challenging for this small‐seeded crop. A controlled‐environment experiment was conducted to assess the impact of seed treatment and pelleting on pennycress germination and seedling vigor of four pennycress lines (three black and one golden colored seed) following storage for 0, 1, 3, 9, and 12 months in warm or cold conditions (23°C or 10°C, respectively). Seeds were either treated with a gibberellin A4+7 (GA) soak (positive control), seed pelleting, or pelleting with GA added to the binder solution in addition to the untreated control (negative control). After each storage duration, seeds were germinated in darkness and counted daily for 7 days to obtain total germination. Vigor indices were calculated using changes in daily germination values. For black‐seeded lines, GA treatment increased germination over the untreated by 5%–75% and pelleting alone increased germination by 4%–30%, but only until 3 months of storage. The GA treatment did not increase germination of the golden‐seeded line, and pelleting decreased germination after 3 months of storage. The GA soak treatment was most effective at improving seed vigor indices compared with other treatments, while pelleting negatively affected vigor scores at 9 and 12 months of storage. Similar effects on germination from treatment were observed under both warm and cold storage conditions. Results indicate seed treatment can benefit germination and vigor within 3 months of storage for black‐seeded lines but may negatively affect performance of golden‐seeded lines, or all pennycress seed types after 9 months of storage.
The brachytic2 mutation alone or its combination with the brown midrib3 mutation improves fiber digestibility in forage maize
Authors: Bourdoncle William , Lemke Bryce , Maloney Peter , Pellet Jean‐Luc , Zhao Jing , Fouquet Romain , Cargill Edward , Barten Ty 
Published: August 2023

AbstractShort stature maize (SSM), which carries the brachytic2 (br2) mutation, has reduced plant height and increased plant standability. Since a large area of maize (Zea mays L.) is planted for silage, it is important to investigate the forage nutritive value of SSM. Our aim was to evaluate the effect of the br2 mutation alone or its combination with the brown midrib3 (bm3) mutation on feeding value parameters, notably fiber digestibility and lignification. SSM hybrids had forage feeding value equivalent to BMR hybrids and better than that of tall hybrids. The br2 mutation significantly increased fiber digestibility in the sets of near‐isogenic inbreds by 4 percentage units and hybrids by 2.7 percentage units. Those favorable effects could be attributed to reduction in lignin concentration and changes in the distribution of lignin within the stem. Furthermore, the combination of br2 with bm3 resulted in an increase in fiber digestibility, which appeared to be additive. Altogether, our results indicated that SSM has the potential to create fodder of high feeding value and favorable standability.
Environmental flow assessment for benthic macroinvertebrate communities using pseudo‐2D hydraulic habitat modelling at a green small hydropower plant
Authors: Hu Shuyi , Feng Meili , Xu Shuyang , Wu Chaofan , Zeng Zhen 
Published: August 2023

AbstractThe determination of minimum flow requirements for green small hydropower plants (GSHP) in China primarily relies on hydrological methods such as the Tennant method with no seasonal variation. However, the direct application of hydrological methods without local ecological data for calibration lacks ecological validity, potentially resulting in unsuitable minimum flow recommendations for local aquatic biota. Hydraulic‐habitat modelling (HHM) is assumed to provide more ecologically relevant and reliable environmental flow recommendations (EFRs), but benthic macroinvertebrates (BMs), crucial in the aquatic food web, have rarely been the focus in HHM studies. Moreover, the strong subjectivity in HHM processes hinders the comparison of EFRs across different biota and geographical regions. This study aims to investigate the ecological validity of using the Tennant method to set minimum flow requirements for local BM communities and the impacts of various methods used in HHM on derived EFRs. To achieve this, a pseudo‐2D HHM approach is employed, integrating the 1D hydraulic models HEC‐RAS and CASiMiR with the habitat model HABFUZZ. The EFRs downstream of Jiufeng reservoir, one of China's first GSHPs, are derived for wet (April–June) and dry seasons (July–September). Our findings highlight that setting minimum flow alone is inadequate for preserving BM community integrity downstream of GSHPs. It is crucial to incorporate more diverse environmental flow criteria, including minimum flows and peak flows, into GSHP assessment standards, with recommended flow levels varying across different seasons. Additionally, the development of a standardized HHM methodology is essential to mitigate the inherent subjectivity in HHM and facilitate the comparison of EFRs generated from different studies. This study's innovative modelling framework and findings will enhance the optimization of minimum flow assessment criteria for GSHP in China, deepen understanding of seasonal e‐flow requirements of BM communities, and refine the methodology used in BM HHM for e‐flow recommendation.
Diastolic exercise stress testing in heart failure with preserved ejection fraction: The DEST‐HF study
Authors: Wernhart Simon , Goertz Annika , Hedderich Juergen , Papathanasiou Maria , Hoffmann Julia , Rassaf Tienush , Luedike Peter 
Published: August 2023

AbstractAimsPulmonary capillary wedge pressure (PAWP) ≥25 mmHg during bicycle ergometry is recommended to uncover occult heart failure with preserved ejection fraction. We hypothesized that PAWP increase would differ in available diastolic stress tests and that the margin of PAWP ≥25 mmHg would only be reliably achieved through ergometry.Methods and resultsWe conducted a prospective, single‐arm study in patients with an intermediate risk for heart failure with preserved ejection fraction according to the ESC HFA‐PEFF score. A total of 19 patients underwent four stress test modalities in randomized order: leg raise, fluid challenge, handgrip, and bicycle ergometry. The primary outcome was the difference (Δ) between resting and exercise PAWP in each modality. Secondary outcomes were differences (Δ) in mean pulmonary artery pressure (mPAP), cardiac output (CO), as well as the ratios between mPAP and PAWP to CO. Compared to resting values, passive leg raise (Δ7.7 ± 8.0 mmHg, p = 0.030), fluid challenge (Δ9.2 ± 6.4 mmHg, p = 0.003), dynamic handgrip (Δ9.6 ± 7.5 mmHg, p = 0.002), and bicycle ergometry (Δ22.3 ± 5.0 mmHg, p < 0.001) uncovered increased PAWP during exercise. Amongst these, bicycle ergometry also demonstrated the highest ΔmPAP (27.2 ± 7.1 mmHg, p < 0.001), ΔCO (3.3 ± 2.6 L/min, p < 0.001), ΔmPAP/CO ratio (2.3 ± 2.0 mmHg/L/min, p < 0.001), and ΔPAWP/CO ratio (2.2 ± 1.4 mmHg/L/min, p < 0.001) compared to other modalities. PAWP ≥25 mmHg was only reliably achieved in bicycle ergometry (31.1 ± 3.9 mmHg). In all other modalities only 10.5% of patients achieved PAWP ≥25 mmHg (handgrip 18.4 ± 6.6 mmHg, fluid 18.1 ± 5.6 mmHg, leg raise 16.5 ± 7.0 mmHg).ConclusionsWe demonstrate that bicycle ergometry exhibits a distinct haemodynamic response with higher increase of PAWP compared to other modalities. This finding needs to be considered for valid detection of exercise PAWP ≥25 mmHg when non‐bicycle tests remain inconclusive.