bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling the band gap of spinel nano-ferrite material using a genetic algorithm based support vector regression computational method
Authors: Olatunji Sunday O. , Owolabi Taoreed O. 
Published: February 2023

Abstract
Spinel nano-ferrite compounds have attracted significant interest in industrial, scientific and technological communities as a result of their promising and unique features especially at nano-scale range. The present and future potentials of spinel nano-ferrite materials cut across several applications such as biotechnology, magnetic storage, sensors, magnetic hyperthermia, microwave absorbance and photo-catalysis. Enhancing the photocatalytic application of spinel nano-ferrite materials involves accommodation of foreign materials into the parent compound as well as appropriate fabrication technique which respectively alter the crystal structure and nano-size of the spinel nano-ferrite materials. This work implements the crystal lattice distortion and the size of nano-particles to develop, for the first time, hybridization of a support vector regression algorithm with a genetic algorithm for estimating the energy gap of doped spinel nano-ferrite materials. The developed hybrid genetic algorithm based support vector regression model was built using two hundred different spinel nano-ferrite materials doped with varieties of materials and synthesized through various methods. The developed genetic algorithm based support vector regression model that is characterized by low root mean square error and mean squared error of 0.3075 eV and 0.095 eV respectively, was further validated using eighteen different spinel nano-ferrite materials and the estimated energy gaps agree excellently with the experimental values. The influence of magnesium, aluminum and lanthanum on the band gap of spinel ferrite nanoparticles was investigated and studied using the developed genetic algorithm based support vector regression model. The developed model in this work ultimately provides a quick, accurate and precise method of characterizing the band gap of spinel nano-ferrite materials while circumventing experimental stress with conservation of appreciable time and other valuable resources.
Pain acceptance and psychological inflexibility predict pain interference outcomes for persons with chronic pain receiving pain psychology
Authors: Karayannis Nicholas Vasilis , Sturgeon John A. , Kemani Mike K. , Mackey Sean C. , Greco Carol M. , Wicksell Rikard K. , McCracken Lance M. 
Published: February 2023

Abstract

Objectives
Awareness (being present), acceptance, and engagement (committed action) are three dimensions of psychological flexibility. Understanding these in the context of chronic pain may identify treatment targets to help refine individual treatment. Our objective was to test the predictive capacity of three dimensions within the psychological flexibility model on the longitudinal trajectory of pain interference.

Methods
Patients receiving pain psychology treatment at a pain management center participated in this pragmatic clinical longitudinal study (n=86 with at least three assessments; Mean age=51 years; Gender=60 females, 26 males). Measures included the Five Facet Mindfulness Questionnaire (FFMQ-SF); Chronic Pain Acceptance Questionnaire (CPAQ-8); Psychological Inflexibility in Pain Scale (PIPS-12); and Committed Action Questionnaire (CAQ-8). The dependent variable was the Patient Reported Outcomes Information System (PROMIS) Pain Interference (PI). We used latent growth modelling to analyze scores assessed within 180 days of patient care.

Results
Psychological inflexibility (PIPS-12) and pain acceptance (CPAQ-8) measured at baseline predicted PI outcomes (n=86). PIPS-12 showed a direct relationship with pain interference (PI), where higher PIPS-12 scores predicted significantly higher PI mean scores on average across the study period (ρ=0.422, r2=0.382) but also predicted significantly greater decreases in PI across time (ρ=−0.489, r2=0.123). Higher CPAQ-8 scores predicted significantly lower PI mean scores on average across the study period (ρ=−0.478, r2=0.453) but also significantly smaller decreases in PI across time (ρ=0.495, r2=0.076). Awareness (FFMQ-SF) and engagement (CAQ-8) were not predictive of PI outcomes.

Conclusions
Patients who entered pain psychology treatment with lower pain acceptance and higher psychological inflexibility showed the largest reductions in pain interference across time. These results contribute towards a novel prognostic understanding of the predictive roles of an enhancing dimension and limiting dimension of psychological flexibility.
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation
Authors: Tristán‐Noguero Alba , Fernández‐Carasa Irene , Calatayud Carles , Bermejo‐Casadesús Cristina , Pons‐Espinal Meritxell , Colini Baldeschi Arianna , Campa Leticia , Artigas Francesc , Bortolozzi Analia , Domingo‐Jiménez Rosario , Ibáñez Salvador , Pineda Mercè , Artuch Rafael , Raya Ángel , García‐Cazorla Àngels , Consiglio Antonella 
Published: February 2023

AbstractTyrosine hydroxylase deficiency (THD) is a rare genetic disorder leading to dopaminergic depletion and early‐onset Parkinsonism. Affected children present with either a severe form that does not respond to L‐Dopa treatment (THD‐B) or a milder L‐Dopa responsive form (THD‐A). We generated induced pluripotent stem cells (iPSCs) from THD patients that were differentiated into dopaminergic neurons (DAn) and compared with control‐DAn from healthy individuals and gene‐corrected isogenic controls. Consistent with patients, THD iPSC‐DAn displayed lower levels of DA metabolites and reduced TH expression, when compared to controls. Moreover, THD iPSC‐DAn showed abnormal morphology, including reduced total neurite length and neurite arborization defects, which were not evident in DAn differentiated from control‐iPSC. Treatment of THD‐iPSC‐DAn with L‐Dopa rescued the neuronal defects and disease phenotype only in THDA‐DAn. Interestingly, L‐Dopa treatment at the stage of neuronal precursors could prevent the alterations in THDB‐iPSC‐DAn, thus suggesting the existence of a critical developmental window in THD. Our iPSC‐based model recapitulates THD disease phenotypes and response to treatment, representing a promising tool for investigating pathogenic mechanisms, drug screening, and personalized management.
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors
Authors: Taubenschmid‐Stowers Jasmin , Orthofer Michael , Laemmerer Anna , Krauditsch Christian , Rózsová Marianna , Studer Christian , Lötsch Daniela , Gojo Johannes , Gabler Lisa , Dyczynski Matheus , Efferth Thomas , Hagelkruys Astrid , Widhalm Georg , Peyrl Andreas , Spiegl‐Kreinecker Sabine , Hoepfner Dominic , Bian Shan , Berger Walter , Knoblich Juergen A , Elling Ulrich , Horn Moritz , Penninger Josef M 
Published: February 2023

AbstractThe natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy. Artemisinin and its derivates are endoperoxides that damage proteins in eukaryotic cells; their definite mechanism of action and host cell targets, however, have remained largely elusive. Using yeast and haploid stem cell screening, we demonstrate that a single cellular pathway, namely porphyrin (heme) biosynthesis, is required for the cytotoxicity of Artemisinins. Genetic or pharmacological modulation of porphyrin production is sufficient to alter its cytotoxicity in eukaryotic cells. Using multiple model systems of human brain tumor development, such as cerebral glioblastoma organoids, and patient‐derived tumor spheroids, we sensitize cancer cells to dihydroartemisinin using the clinically approved porphyrin enhancer and surgical fluorescence marker 5‐aminolevulinic acid, 5‐ALA. A combination treatment of Artemisinins and 5‐ALA markedly and specifically killed brain tumor cells in all model systems tested, including orthotopic patient‐derived xenografts in vivo. These data uncover the critical molecular pathway for Artemisinin cytotoxicity and a sensitization strategy to treat different brain tumors, including drug‐resistant human glioblastomas.
OONO–/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage
Authors: Lei Kun , Wei Quanwei , Cheng Ying , Wang Zhe , Wu Haoze , Zhao Fang , Ding Wei , Shi Fangxiong 
Published: February 2023

In brief
The apoptosis of granulosa cells (GCs) is the main reason for porcine follicular atresia. This study provides a novel mechanism for peroxynitrite anion-mediated GC apoptosis and follicular atresia in porcine ovary.

Abstract
Granulosa cells play a crucial role in the development of follicles, and their cell apoptosis in the porcine ovary is a major contributor to follicular atresia. Here, we provide a new mechanism for follicular atresia by describing a crucial mechanism by which peroxynitrite anion (OONO–) may cause GC death. We discovered that nitric oxide, oxidative stress level, and OONO– were positively correlated with porcine follicular atresia, which was accompanied by high expression of matrix metalloproteinase 2 (MMP2) and MMP9. We created a model of OONO–-induced apoptosis in GCs and discovered that OONO– could boost the expression of MMP2 and MMP9 and increase the expression of pro-apoptotic proteins and DNA damage. Furthermore, by inhibiting the activities of MMP2 and MMP9, we found that SB-3CT (a specific inhibitor for MMP2 and MMP9) alleviated the decrease in cell survival rates and DNA damage caused by OONO–, which may have been impacted by reducing the cleavage of PARP1 by MMP2 and MMP9. Therefore, our findings imply that OONO– can cause DNA damage to GCs, participating in mediating the expression of pro-apoptotic proteins and inhibiting DNA repair by preventing the activity of PARP1 through MMP2 and MMP9. These results help explain how OONO–/MMP2/MMP9 affects porcine follicular atresia and GC apoptosis.
Intensifiers and epistemic adverbials – On the history of German echt ‘really, lit. real/genuine’
Authors: Ørsnes Bjarne 
Published: February 2023

Adverbials of truth or reality such as really (en.), wirklich (de.), verdaderamente (sp.) are cross-linguistically assumed to be a rich source for intensifiers (degree words) as in: (i) Peter is really nice. The epistemic adverbial is reanalysed as a modifier of a predicative adjective in a syntactically ambiguous sentence as in (i). At the same time the emphasis on the truth of the proposition invites the inference that the property in question is amply present. This view on the emergence of intensifiers from adverbials of truth is challenged by the German intensifier echt ‘really, lit. genuine/real’ as in: (ii) Peter ist echt nett ‘Peter is really nice’. In contemporary German echt is very popular as an intensifier, a proposition modifier, a speech-act modifier and a response particle. However, a diachronic analysis of the use of echt as an adverbial in New High German reveals that the intensifier reading develops much earlier than the reading as a proposition modifier, i.e. an epistemic adverbial. The article offers a discussion of the development of echt which sheds a somewhat different light on the relation between intensifiers and epistemic adverbials, and it suggests a unified analysis of the uses of echt in contemporary German which supports Traugott’s view of grammaticalisation as also encompassing an extension of structural scope.
Development, psychometric validation, and cross-cultural comparison of the “Instagram Motives Questionnaire” (IMQ) and the “Instagram Uses and Patterns Questionnaire” (IUPQ)
Authors: Romero Saletti Silvana Melissa , Van den Broucke Stephan , Billieux Joël , Karila Laurent , Kuss Daria J. , Rivera Espejo José Manuel , Sheldon Pavica , Lang Cathryne P. , Zimmer-Gembeck Melanie J. , Zollo Palmyra , Courboin Clara , Diez Dominica , Madison T. Phillip , Ramos-Diaz Jano , Eguia Elias César Augusto , Otiniano Fiorella 
Published: February 2023

AbstractBackground and aimsSocial network use is widespread, and the study of Instagram seems to have captured more attention in recent years. However, scale development and validation in the field has fallen short of providing sound scales of Instagram motives and usage patterns that consider the uniqueness of Instagram-related behavior. This paper describes the development, psychometric and cross-cultural validation of two new measurement instruments: the “Instagram Motives Questionnaire” (IMQ) and the “Instagram Uses and Patterns Questionnaire” (IUPQ).Methods and resultsA preliminary set of items was developed for each questionnaire based on a previous qualitative interview study on Instagram motives, uses, and consequences. In the first study, the questionnaires were distributed to a sample of 312 participants aged 18–35 years (M = 23.81; SD = 4.49), and an exploratory factor analysis was performed. A parsimonious and interpretable 6-factor solution that displayed adequate factor loadings and adequate Omega coefficients for both instruments were found. In a second study, the two instruments and other measures of known social network usage correlates and mental health consequences were administered online to 1,418 English-speaking participants aged 18–34 years (M = 21.35; SD = 3.89). Both scales showed good psychometric properties and the factor structure identified in study 1 was reproduced through confirmatory factor analysis. Omega reliability coefficients were adequate. Finally, when performing multi-group CFA along with a French (n = 1,826) and a Spanish (n = 3,040) sample, language and gender invariance were supported. Correlations with other relevant measures indicate good convergent validity of both scales.ConclusionsThe present research provides psychometrically sound instruments for further investigations on Instagram use behaviors.
Seamless GPU Acceleration for C++-Based Physics with the Metal Shading Language on Apple’s M Series Unified Chips
Authors: Gebraad Lars , Fichtner Andreas 
Published: February 2023

Abstract
The M series of chips produced by Apple has proven a capable and power-efficient alternative to mainstream Intel and AMD ×86 processors for everyday tasks. In addition, the unified design integrating the central processing and graphics processing unit (GPU), have allowed these M series chips to excel at many tasks with heavy graphical requirements without the need for a discrete GPU) in some cases even outperforming discrete GPUs. In this work, we show how the M series chips can be leveraged using the Metal Shading Language (MSL) to accelerate typical array operations in C++. More important, we show how the usage of MSL avoids the typical complexity of compute unified device architecture (CUDA) or OpenACC memory management by allowing the central processing unit (CPU) and GPU to work in unified memory. We demonstrate how performant the M series chips are on standard 1D and 2D array operations such as array addition, single-precision A·X plus Y, and finite-difference stencils, with respect to serial and OpenMP-accelerated CPU code. The reduced complexity of implementing MSL also allows us to accelerate an existing elastic wave equation solver (originally based on OpenMP-accelerated C++) while retaining all CPU and OpenMP functionality without modification. The resulting performance gain of simulating the wave equation is near an order of magnitude for large domain sizes. This gain attained from using MSL is similar to other GPU-accelerated wave-propagation codes with respect to their CPU variants but does not come at much increased programming complexity that prohibits the typical scientific programmer to leverage these accelerators. This result shows how unified processing units can be a valuable tool to seismologists and computational scientists in general, lowering the bar to writing performant codes that leverage modern GPUs.
Do physicians lead healthier lifestyles than when they were students?
Authors: Klocek Tomasz , Witek Przemysław , Wawrzonkowski Patryk , Binek Aleksandra , Woźniak Nadia , Krzych Łukasz 
Published: February 2023

WstępStyl życia jest głównym determinantem zdrowia, może jednak zmieniać się z biegiem lat. Studentów cechują zwykle „gorsze” zachowania zdrowotne niż te u osób dorosłych. To ciekawe zjawisko nie było badane w środowisku lekarskim. Celem pracy była ocena stylu życia lekarzy w porównaniu z ich zachowaniami z lat studenckich.Materiał i metodyBadanie przekrojowe przeprowadzono w 2020 r. z wykorzystaniem autorskiego kwestionariusza oceniającego różne elementy stylu życia, które klasyfikowano jako „zdrowe” lub „niezdrowe” na podstawie rekomendacji Światowej Organizacji Zdrowia. W badaniu uczestniczyło 112 lekarzy (64,3% mężczyzn i 35,7% kobiet); mediana wieku wynosiła 37 lat (IQR 36–38). Wyniki porównano z danymi otrzymanymi w tej grupie na podstawie tego samego kwestionariusza dystrybuowanego w latach 2003–2005, tj. gdy badani byli studentami medycyny.WynikiZaobserwowano istotne, korzystne zmiany dotyczące rzadszego spożycia posiłków z dużą zawartością soli kuchennej (p < 0,01) oraz częstszego spożycia warzyw i owoców (p < 0,01). Zaobserwowano zwiększenie częstości picia kawy (p < 0,01). W pozostałym zakresie nawyki żywieniowe i stosowanie używek pozostawały niezmienne. Nie stwierdzono różnic dotyczących aktywności fizycznej, występowania stresu oraz jego charakteru (mobilizujący/destabilizujący).WnioskiStyl życia lekarzy nie zmienia się znacząco w porównaniu z latami studenckimi, co można wiązać z przyzwyczajeniami z lat młodości.
Assessment of Libido and Semen Quality of Boar by using Low-cost Portable Wooden Dummy Sow
Authors: Talukdar Dibyajyoti , Luwang Athokpam Donin , Lalrintluanga Khawlhring , Tolenkhomba T.C. , Das Hemen , Kalita Girin , Sarma Kalyan 
Published: February 2023

Background: Artificial Insemination in pigs is much easier than other domestic species but the training of boar for the collection of semen is a big constraint. Certain boars are not acquainted with the fixed steel dummy sow and the surrounding environment. Hence, the dummy sows brought in the boar’s pen. The steel dummy sow in comparison to wooden is too heavy and found difficult to bring in a boar’s pen. Moreover, the wooden dummy sows are locally made and it becomes cost-effective too. The present study was designed to assess the libido and semen quality of boars by using locally made low-cost portable wooden dummy sows. Methods: The study was conducted on 16 numbers of Large White Yorkshire (LWY) and Mizoram local Zovawk crossbred boars at the age of 10-12 months. The semen collection was done by using a homemade portable “wooden dummy sow” and steel made “fixed dummy sow.” The training was done every morning before feeding and semen was collected twice a week by using the gloved hand method when the boars mounted over the dummy sow by holding protruded and erected corkscrew end of the penis firmly. During collection, libido characteristics of the boars were recorded and semen quality was determined. Result: The duration of training taken by the boars for semen collection was significantly (P less than 0.01) less in portable wooden dummies. The sexual behaviour and other behavioural traits were better when boars were trained on a portable wooden dummy. The mean semen volume, sperm mass activity, pH and sperm concentration of LWY crossbred boar was not significantly different between fixed steel and portable wooden dummy. The percentage of initial sperm motility and intact acrosome of boar spermatozoa was significantly (P less than 0.05) higher in portable wooden dummy. In conclusion, the homemade portable “wooden dummy sow” was found to be very effective for the training and collection of semen from breedingboars.
A OBRA NECROFOBIA (2014) COMO REPRESENTAÇÃO DO CINISMO MODERNO ARGENTINO
Authors: Germano Pedro da Cunha 
Published: February 2023

Este artigo prevê a compreensão das associações existentes entre a narrativa da obra cinematográfica argentina Necrofobia (2014) e a estrutura do cinismo moderno, segundo Peter Sloterdijk (1987), no intuito de analisar como o filme em questão trabalha sua narrativa de horror artístico para a construção da representação do horror social real. A partir da análise do cinema como forma de reflexo da sociedade, trabalhada por Siegfried Kracauer (1985), o texto toma a narrativa da obra audiovisual para explorar a relação entre o cinismo moderno que adentrou à sociedade latino-americana e a ideologia fascista que se articula no arco narrativo do protagonista da obra.
Multiple indicators of violence against female sex workers and its associated factors in Ghana: Evidence from the 2015 Integrated Bio-Behavioural Surveillance Survey
Authors: Ayamah P , Atuahene KS , Annang DA , Nartey DT , Amuasi SA , Abrefa-Gyan T , Aheto Justice Moses K. 
Published: February 2023

Abstract
Background and Aims: Violence against female sex workers (FSWs) is a widespread phenomenon, especially in African nations like Ghana where sex work is outlawed primarily because of the pervasive worldview that sex work is a contravention of morality. Violence against FSWs deters them from accessing critical health services and heightens their risk of STIs including HIV infection. The study examined the prevalence and the associated factors of multiple indicators of violence against FSWs.
Methods: The study utilised a cross-sectional secondary data from the 2015 Integrated Bio-Behavioural Surveillance Survey (IBBSS) conducted among FSWs and their non-paying partners by Ghana AIDS Commission (GAC). We analysed data on a total of 4279 participants. Bivariate, and multivariable logistic regression analyses were utilized to identify factors associated with physical and sexual violence against FSWs. Data were analysed using Stata version 15.
Results: The prevalence of physical and sexual violence were 10% and 25% respectively. Physical violence was perpetrated mainly by first-time paying clients (51%) and regular paying clients (31%) with similar trend observed for sexual violence. The predictors of physical violence are being a seater (aOR=0.53, 95%CI: 0.36-0.74), aged ≥40 (aOR=0.23, 95%CI: 0.08-0.64), non-use of drugs (aOR=0.56, 95%CI: 0.44-0.70), and not using alcohol before sex (aOR=0.69, 95%CI: 0.56-0.86). Sexual violence was predicted by those aged age 31-40 (aOR=0.68, 95%CI: 0.49-0.94) and age≥40 (aOR=0.38, 95%CI: 0.22-0.66), currently married (aOR=0.42, 95%CI: 0.27-0.67), having no living children (aOR=0.69, 95%CI: 0.51-0.94), non-use of drugs (aOR=0.80, 95%CI: 0.68-0.94), and not using alcohol before sex (aOR=0.74, 95%CI: 0.63-0.86). Both physical and sexual violence had negative consequences on consistency of condom use and condom failure among FSWs.
Conclusion: Physical and sexual violence against FSWs is pervasive, and a critical public health issue in Ghana. The identified associated factors could be considered as part of an overall strategy aimed at addressing the menace.