bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in serum albumin concentrations over 7 days in medical inpatients with and without nutritional support.
A secondary post-hoc analysis of a randomized clinical trial
Authors: Boesinger Fabienne , Poggioli Alessia , Netzhammer Claudine , Bretscher Céline , Kaegi Nina , Tribolet Pascal , Gressies Carla , Kutz Alexander , Stanga Zeno , Mueller Beat , Schuetz Philipp , Schütz Philipp 
Published: March 2023

Abstract
Background
Serum albumin concentrations are frequently used to monitor nutritional therapy in the hospital setting but supporting studies are largely lacking. Within this secondary analysis of a randomized nutritional trial (EFFORT), we assessed whether nutritional support affects short-term changes in serum albumin concentrations and whether an increase in albumin concentration has prognostic implications regarding clinical outcome and response to treatment.
Methods
We analyzed patients with available serum albumin concentrations at baseline and day 7 included in EFFORT, a Swiss-wide multicenter randomized clinical trial that compared individualized nutritional therapy with usual hospital food (control group).
Results
Albumin concentrations increased in 320 of 763 (41.9%) included patients (mean age 73.3 years (SD ± 12.9), 53.6% males) with no difference between patients receiving nutritional support and controls. Compared with patients with decrease in albumin concentrations, those with an increase had a lower 180-day mortality [74/320 (23.1%) vs. 158/443 (35.7%); adjusted odds ratio 0.63, 95% CI 0.44 to 0.90; p = 0.012] and a shorter length of hospital stay [11.2 ± 7.3 vs. 8.8 ± 5.6 days, adjusted difference − 2.2 days (95%CI -3.1 to -1.2)]. Patients with and without an increase in albumin concentrations from baseline to day 7 showed a similar response to nutritional support.
Conclusion
Results from this secondary analysis indicate that nutritional support did not increase short-term concentrations of albumin, and changes in albumin did not correlate with response to nutritional interventions. However, an increase in albumin concentrations was associated with better clinical outcomes. Repeated in-hospital albumin measurements in the short-term is, thus, not indicated for monitoring of patients receiving nutritional support but provides prognostic information.
Trail Registration:
ClinicalTrials.gov Identifier: NCT02517476
Comparison of Frontal QRS-T Angle of Patients with Nasal Septal Deviation with Healthy Controls
Authors: KAPICI Olga BAYAR , Abuş Sabri , Ayhan Selçuk , Koparal Mehtap , Kaya Hakan 
Published: March 2023

Abstract
Background: This study compares frontal QRS-T angle (fQRS-T) in electrocardiogram (ECG) examinations of people with nasal septal deviation (NSD) with healthy controls (HC).
Methods: Eighty-two patients whom a radiologist with paranasal computed tomography definitively diagnosed with NSD were included in the study. 101 individuals without NSD were selected as HC.
Results: Compared to the HC group, the fQRS-T in was considerably wider in patients with NSD (p<.001). According to Spearman correlation analysis, fQRS-T and NSD angle, and platelet lymphocyte ratio (PLR) were significantly correlated (p=.021, p<.001, and p=.003, respectively). In linear regression analysis where the fQRS-T was taken as a dependent variable, NSD angle and PLR predicted the fQRS-T significantly and positively (F(5.76)=8.451, R2=.357, Adjusted R2=.315 and p<.001).
Conclusion: Based on our findings and literature, the fQRS-T may predict cardiac outcomes in patients with NSD due to acute and persistent effects.
Incidental dural tear in spinal surgery complicated by pneumocephalus with abducens (VI) paralysis: a case-report and literature review
Authors: Marie-Hardy Laura , Kalamarides Michel , Pascal-Moussellard Hugues 
Published: March 2023

Abstract
Introduction: Incidental dural tears are a frequent complication of spinal surgery that may lead to various neurologic complications.
Case presentation: Here is describe the case of an 83 years-old female, that underwent a lumbar decompression revision surgery, complicated by an incidental dural. The patient presented in post-operative care an acute onset monocular horizontal diplopia with homolateral ptosis and multiple extra-axial bi-frontal signal voids on the cerebral CT-scan, evoking pneumencephalus. The symptomatology resolved with conservative treatment (dorsal decubitus, monocular external occlusion, and close monitoring). The initial presentation with predominant ophthalmologic clinical signs is at our knowledge the first one to be described after lumbar laminectomy.
Conclusion: Diplopia in a context of post-operative spinal surgery must evoke pneumencephalus and might require an urgent cerebral imaging to assess diagnosis.
Design of NoSQL Database in Oral English Teaching based on 5G Network and AI Recognition
Authors: Liu Liu 
Published: March 2023

Abstract
With the continuous development of science and technology, we have fully entered the information age, people's entertainment life is becoming more and more abundant, and the Internet has also provided people with a lot of convenience. The advent of the Internet age means that more and more various kinds of data are appearing, and the situation is becoming more and more abundant. The use of traditional relational databases can no longer store these data, nor can it be queried. With the continuous development of voice technology, database technology based on NoSQL has become a research hotspot. The availability of NoSQL databases is very high, the scalability is also very high, and the efficiency is very high when processing data. Based on the development of 5G networks and the development of big data technology, this research proposes a brand-new business architecture. This architecture can use the network to store data on the basis of massive data. At the same time, we also described the business scenario, providing a new idea for more intelligent education services. We use this model for teaching in schools, and we can transmit some spoken language resources to the school through the Internet for students to use for learning. Nowadays, the application range of AI technology and intelligent technology has become more and more extensive, and these technologies have also been applied in the education field. We can apply this brand-new technology in teaching to promote the development of teaching and improve students' enthusiasm and learning effect.
Approximating outcome probabilities of linear optical circuits
Authors: Lim Youngrong , Oh Changhun 
Published: March 2023

Abstract
Quasiprobability representation is an important tool for analyzing a quantum system, such as a quantum state or a quantum circuit.
In this work, we propose classical algorithms specialized for approximating outcome probabilities of a linear optical circuit using $s$-parameterized quasiprobability distributions. Notably, we can reduce the negativity bound of a circuit from exponential to at most polynomial for specific cases by modulating the shapes of quasiprobability distributions thanks to the symmetry of the linear optical transformation in the phase space.
Consequently, our scheme renders an efficient estimation of outcome probabilities within an additive error whose precision depends on the classicality of the circuit.
When the classicality is high enough, we reach a polynomial-time estimation algorithm of a probability within a multiplicative error by an efficient sampling from the log-concave function.
By choosing appropriate input states and measurements, our results provide plenty of quantum-inspired classical algorithms for approximating various matrix functions beating best-known results. Moreover, we give sufficient conditions for the classical simulability of Gaussian boson sampling using the approximating algorithm for any (marginal) outcome probability under the poly-sparse condition.
Voting by Mouth: Media Attention and Environmental Governance
Authors: Shi Peihao , Yin Lihui , Wu Chuanqing 
Published: March 2023

Abstract
External oversight is critical to enhancing environmental protection. In this paper, we investigate the implication of media attention on corporate environmental governance during the period 2011–2021 by taking China’s public companies as samples. The empirical results indicate that media attention can significantly and persistently amplify corporate environmental governance, and this result is stable after considering both endogeneity and a series of alternative robustness tests. Additionally, in areas with higher marketization and better rules of law environments, media attention can be better in favor of improving corporate environmental performance. Further analysis finds that media attention is favorable to corporate environmental governance through the "supervisory effect" mechanisms, including raising public awareness, improving internal management efficiency, as well as leveraging innovation to reduce environmental damage. The conclusions of this study provide empirical evidence for enhancing external supervision and corporate governance.
Joint effect of whole blood metals exposure with dyslipidemia in representative U.S adults in NHANES 2011-2020
Authors: Liang Jing-hong , Pu Ying-qi , Liu Mei-ling , Hu Li-xin , Bao Wen-wen , Zhang Yu-shan , Kakaer Aerziguli , Zhao Yu , Chen Yi-can , Pu Xue-ya , Huang Shao-yi , Jiang Nan , Huang Shan , Dong Guang-hui , Chen Ya-jun 
Published: March 2023

Abstract
With little knowledge on the joint effects of metal exposure on dyslipidemia, we aimed to investigate the relationship between exposure to metal and dyslipidemia among U.S adults based on the National Health and Nutrition Examination Survey(NHANES). Based on the five NHANES waves(2011-2020), we selected five metals in blood as exposure, namely, Cadmium(Cd), Lead(Pb), Total Mercury(Hg), Manganese(Mn) and Selenium(Se), which were detected by inductively coupled plasma mass spectrometry. Survey-multivariable logistic regression, Generalized Weighted Quantile Sum(WQS) and Bayesian kernel machine regression(BKMR) were performed to determine whether dyslipidemia was associated with single metals or mixed metals. Our study included 12,526 participants aged from 20 to 80, representing 577.1 million non-institutionalized U.S. adults. We found a positive association between several metals including Pb [Adjusted odds ratio(AOR)=1.332, 95%CI:1.165, 1.522], Total Hg(AOR=1.264, 95%CI:1.120, 1.427), Mn(AOR=1.181, 95%CI:1.046, 1.334) and Se(AOR=1.771, 95%CI:1.576, 1.992) and dyslipidemia. According to the WQS approach, metal mixtures were positively associated with dyslipidemia(AOR:1.310, 95%CI: 1.216, 1.411) after a full-model adjustment. As is shown in the BKMR model, mixed metals tended to be positively associated with dyslipidemia ratios in a significant manner. Females, non-Hispanic white populations, people aged over 60 and those who did a little physical activity had a greater risk for dyslipidemia. Our findings suggest metals including Cd, Pb, Hg, Mn and Se and their combinations may adversely affect dyslipidemia among U.S adults. Due to the cross-sectional nature of the study, it is possible that reverse causation may exist.
Optimized impulsive noise filtering method for rolling bearing signal enhancement
Authors: Xu Yuanbo , Wei Yu , Qu Junsuo 
Published: March 2023

Abstract
In this paper, we discuss the issue of bearing fault diagnosis in impulsive environments. Such impulsive signals have significant spike impulse characteristics and show the obvious non-Gaussian property. Compare to the cyclic impulsive signals generated by bearing local damage, the impulsive components can be considered to be a special kind of noise, namely impulsive noise. Unfortunately, the impulsive nature of the noise often leads to significant degradation of the performance of the signal processing techniques based on the Gaussian model. To overcome this issue, an impulsive noise filtering method based on Alpha-stable distribution (α-stable filter for short) is designed. Besides, to avoid the blind selection of the order parameter in the designed α-stable filter, the classical particle swarm optimization (PSO) is used to combine with the designed α-stable filter for an optimal parameter. We apply the optimized α-stable filter is applied to both simulated and real signals. The obtained results demonstrate that the filtering method is effective in canceling impulsive noise and enhances the ability to bearing fault detection.
Novel uAUG creating variants in the 5’UTR of ENG causing Hereditary Hemorrhagic Telangiectasia
Authors: Soukarieh Omar , Tillet Emmanuelle , Proust Carole , Dupont Charlène , Jaspard-Vinassa Béatrice , Soubrier Florent , Goyenvalle Aurélie , Eyrie Mélanie , Trégouët David-Alexandre 
Published: March 2023

Abstract
Introduction:
Hereditary Hemorrhagic Telangiectasia (HHT) is a rare vascular disorder causing abnormal vessel formation and characterized by autosomal dominant transmission. About 80% of HHT cases are caused by pathogenic coding variants in ACVRL1 (also known as ALK1) and ENG, and 15% remain unexplained. We identified 2 variants, c.-79C > T and c.-68G > A, in the 5’UTR of ENG in 2 unrelated HHT patients. They are predicted to create upstream AUGs (uAUGs), which are in frame with a stop codon located within the CoDing Sequence (CDS), thus generating Overlapping upstream Open reading frames (uoORFs).
Methods
In order to assess the pathogenicity of these variants, we performed in vitro functional assays based on the expression of wild-type and mutant constructs in human cells and evaluated their effect on ALK1 activity in a BMP-response element (BRE) assay. This assay is a mandatory element before providing a definitive molecular diagnosis and has been so far applied only on coding ENG variants.
Results
We found that these 5’UTR variants were associated with a decrease of protein levels in HeLa and HUVEC cells and a decreased ability to activate BMP9-stimulated ALK1 receptor. We applied the same experimental workflow on 3 additional uoORF-creating variants (c.-142A > T, c.-127C > T and c.-10C > T) located in the 5’UTR of ENG and previously reported in HHT patients. We found that all the analyzed variants alter endoglin levels and function. Moreover, additional experiments relying on an artificial deletion in our mutated constructs show that identified uAUGs are able to initiate the translation indicating that the associated effect is likely caused by an alteration of the translation mechanism.
Conclusion
Overall, we here identified two 5’UTR ENG variations in HHT patients and shed new lights on the role of upstream ORFs on ENG regulation. Our findings contribute to the amelioration of molecular diagnosis in HHT.
Hematologic health services and practical characteristics: report of a nationwide survey among Chinese hematologists
Authors: Chen Jia , Gu Jiali , Ru Yuhua , Wang Jianxiang , Hu Yu , Liu Kaiyan , Liu Qifa , Zhang Xiaohui , Xiao Zhijian , Zhao Weili , Xu Yang , Huang Xiaojun , Wu Depei 
Published: March 2023

Abstract
Background: In the past 40 years, China has experienced tremendous economic development, but the current situation of hematologists has rarely been reported. A landscape survey of human resources is essential for healthcare development and policy formulation in the future.
Methods: The Chinese Society of Hematology initiated a survey of Chinese hematologists in mainland China for evaluating demographic and practice characteristics. Respondents were anonymous, and there were no limitations regarding their age, sex, etc.
Results: Totally 2032 hematologists responded, with a median age bracket of 36-45 years. Respondents were well engaged into subspecialties, and 28.1% acquired doctorates of philosophy. Hematopoietic cell transplantation (HCT) centers have been established all over China. Higher-GDP regions reported more advantages, including bigger scale of transplant centers (P < 0.001), younger age structure (P = 0.039), better education qualifications (P = 0.001) and less turnover intentions (P = 0.004), despite of increased risk of medical disputes (P = 0.028). Although females accounted for 65.5% of hematologists, males were older (P < 0.001), and had more senior professional titles (P < 0.001), academic positions (P < 0.001), opportunities for continuing education (P < 0.001), and paper publishing in the recent two years (P = 0.001). For turnover intention, the higher GDP regions led to an independently reduced risk (HR = 0.673, 95%CI [0.482-0.940], P = 0.020), whereas medical disputes resulted in an increased the risk (HR = 2.037, 95%CI [1.513-2.743], P < 0.001). Considering the impact of the COVID-19 pandemic, majority of respondents believed that the decline in patient visits and delay in treatment was within 30%. 67.9% of respondents reported a decrease of the use of bone marrow as grafts but 18.8% reported an increase of cord blood units. 35.0% of the respondents switched their daily work to support the anti-epidemic medical activities.
Conclusions: We concluded the discipline of hematology in China has flourished in recent years with a young workforce, while regional economic and gender disparities warrant further continuous optimization. Joint efforts against the impact of COVID-19 are needed in the post-pandemic era.
“Be honest and gain trust”: A mixed methods study to understand factors associated with building trust in local government related to COVID-19 and vaccination in three historically disinvested neighborhoods in New York City
Authors: Shiman Lauren J. , Diallo Fatoumata , Nieves Christina I. , Brooks Brandon , Dannefer Rachel , Dorvil Sheena , Lejano Maria , Pierre Jennifer 
Published: March 2023

Abstract
Background
Distrust in government among people of color is a response to generations of systemic racism that have produced preventable health inequities. Higher levels of trust in government are associated with better adherence to government guidelines and policies during emergencies, but factors associated with trust and potential actions to increase trust in local government are not well understood.
Methods
The COVID-19 Community Recovery study sampled participants from the New York City (NYC) Department of Health and Mental Hygiene’s Healthy NYC, a probability-based survey panel who complete health surveys periodically. Participants who lived in one of three historically disinvested communities in NYC where the NYC Department of Health and Mental Hygiene has dedicated resources to reduce health inequities were included. The cross-sectional survey was fielded from September 30 to November 4, 2021 and could be self-administered online or conducted via CATI (Computer Assisted Telephone Interviewing) in English, Spanish, and Simplified Chinese (Mandarin and Cantonese by phone). Demographic data were summarized by descriptive statistics. Crude and adjusted logistic regression analyses were used to assess factors predictive of trust in local government as a source of information about COVID-19 vaccines. Open-ended responses about strengthening residents’ trust in local government were coded using an iteratively generated codebook.
Results
In total, 46% of respondents indicated NYC local government was a trusted source of information about COVID-19 vaccines, relatively high compared to other sources. In bivariate analyses, race/ethnicity, age group, educational attainment, length of time living in NYC, and household income were significantly associated with identifying NYC government as a trusted source of information about COVID-19 vaccines. In multivariable logistic regression, no variables remained significant predictors of selecting local government as a trusted source of information. Key recommendations for local government agencies to build residents’ trust include communicating clearly and honestly, addressing socioeconomic challenges, and enhancing public COVID-19 protection measures.
Conclusions
Study findings demonstrate that nearly half of residents in three historically divested NYC communities consider local government to be a trusted source of information about COVID-19 vaccines. Strategies to increase trust in local government can help reduce community transmission of COVID-19 and protect public health.
The Protective Effect of Interleukin-1 Receptor Antagonist on Kidney Function: A Mendelian Randomization Study
Authors: Park Sehoon , Cho Jeong Min , Koh Jung Hun , Kim Seong Geun , Lee Soojin , Kim Yaerim , Cho Semin , Kim Kwangsoo , Kim Yong Chul , Han Seung Seok , Lee Hajeong , Lee Jung Pyo , Joo Kwon Wook , Lim Chun Soo , Kim Yon Su , Kim Dong Ki 
Published: March 2023

Abstract
Background
Interleukins (ILs), key cytokine family of inflammatory response, are closely associated with kidney function. However, the causal effect of various ILs on kidney function needs further investigation.
Methods
We performed two-sample summary-level mendelian randomization (MR) analysis. Genetic variants with strong association with serum IL levels were obtained from a previous genome-wide association study meta-analysis. Summary-level data for eGFR were obtained from CKDGen database. A replication analysis was performed in the independent UK Biobank data. As a main MR analysis, multiplicative random-effect inverse-variance weighed method was performed. Pleiotropy-robust MR analysis, including MR-Egger with bootstrapped error and weighed-median methods, were also implemented.
Results
We tested the causal estimates from nine ILs on eGFR traits. Among the results, higher genetically predicted serum IL-1ra level was significantly associated with higher eGFR values, both in the CKDGen and the UK Biobank data. In addition, the result was consistent towards eGFR decline phenotype of the outcome database. Otherwise, nonsignificant association was identified between other genetically predicted ILs and eGFR outcome.
Conclusions
These findings support the clinical importance of IL-1 associated pathway in relation to kidney function in the general individuals, particularly highlighting the importance of IL-1ra.
3D Printing of Flexible, Scaled Neuron Models
Authors: Habbal Osama , Farhat Ahmad , Khalil Reem , Pannier Christopher 
Published: March 2023

Abstract
Microscopy-based 3D neuronal reconstructions are freely available online, including in the NeuroMorpho.Org file repository. Each neuron’s dendritic structure is intricate and diverse, making it challenging to produce accurate physical 3D models for instruction or visualization. This work examines several methods for producing 3D models of neuronal reconstructions and compares their cost and accessibility. In response to high cost of direct 3D printing methods, we develop a new casting method which uses 3D-printed, single-use dissolvable molds and achieves lower cost for producing 3D neuron models. The casting method uses a consumer-grade desktop fused filament fabrication 3d printer, water-soluble polyvinyl alcohol filament, and a two-part casting material such as polyurethane resin or silicone rubber. Physical models of a diverse set of neuron morphologies including purkinje, pyramidal, medium spiny, and retinal ganglion cells were produced using the casting method with good fidelity to the neuronal reconstruction file and sufficient detail and strength for hands-on use in neuroscience education and research. The average cost of producing the four neuron models using the proposed casting method was reduced by 58% relative to the cost of using the least expensive 3D printing method by a service provider. Production time for one neuronal model using the proposed method was found to be in the range of 1-3 days while service-provided neurons required a minimum of a week from order placement to delivery.