bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for Primary Aldosteronism Among Hypertensive Adults with Obstructive Sleep Apnea: A Retrospective Population-Based Study
Authors: Hundemer Gregory L , Imsirovic Haris , Kendzerska Tetyana , Vaidya Anand , Leung Alexander A , Kline Gregory A , Goupil Rémi , Madore François , Agharazii Mohsen , Knoll Greg , Sood Manish M 
Published: February 2023

Abstract

BACKGROUND
Hypertension plus obstructive sleep apnea (OSA) is recommended in some guidelines as an indication to screen for primary aldosteronism (PA), yet prior data has brought the validity of this recommendation into question. Given this context, it remains unknown whether this screening recommendation is being implemented into clinical practice.

METHODS
We conducted a population-based retrospective cohort study of all adult Ontario (Canada) residents with hypertension plus OSA from 2009 to 2020 with follow-up through 2021 utilizing provincial health administrative data. We measured the proportion of individuals who underwent PA screening via the aldosterone-to-renin ratio by year. We further examined screening rates among patients with hypertension plus OSA by the presence of concurrent hypokalemia and resistant hypertension. Clinical predictors associated with screening were assessed via Cox regression modeling.

RESULTS
The study cohort included 53,130 adults with both hypertension and OSA, of which only 634 (1.2%) underwent PA screening. Among patients with hypertension, OSA, and hypokalemia, the proportion of eligible patients screened increased to 2.8%. Among patients ≥65 years with hypertension, OSA, and prescription of ≥4 antihypertensive medications, the proportion of eligible patients screened was 1.8%. Older age was associated with a decreased likelihood of screening while hypokalemia and subspecialty care with internal medicine, cardiology, endocrinology, or nephrology were associated with an increased likelihood of screening. No associations with screening were identified with sex, rural residence, cardiovascular disease, diabetes, or respirology subspecialty care.

CONCLUSIONS
The population-level uptake of the guideline recommendation to screen all patients with hypertension plus OSA for PA is exceedingly low.
Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state
Authors: Martín-Suárez Soraya , Cortes Jesús María , Bonifazi Paolo 
Published: February 2023

Abstract
Epilepsy, characterized by recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world’s most prominent neurological disabilities. Seizures, which are an expression of neuronal network dysfunction, occur in a positive feedback loop of concomitant factors, including neuro-inflammatory responses, where seizures generate more seizures. Among other pathways involved in inflammatory responses, the JAK/STAT signalling pathway has been proposed to participate in epilepsy.
Here, we tested an in vitro model of temporal lobe epilepsy, with the hypothesis that acute blockage of STAT3-phosphorylation during epileptogenesis would prevent structural damage in the hippocampal circuitry and the imprinting of both neural epileptic activity and inflammatory glial states. We performed calcium imaging of spontaneous circuit dynamics in organotypic hippocampal slices previously exposed to epileptogenic conditions through the blockage of GABAergic synaptic transmission.
Epileptogenic conditions lead to epileptic dynamics imprinted on circuits in terms of increased neuronal firing and circuit synchronization, increased correlated activity in neuronal pairs and decreased complexity in synchronization patterns. Acute blockage of the STAT3-phosphorylation during epileptogenesis prevented the imprinting of epileptic activity patterns, general cell loss, loss of GABAergic neurons and the persistence of reactive glial states. This work provides mechanistic evidence that blocking the STAT3 signalling pathway during epileptogenesis can prevent patho-topological persistent reorganization of neuro-glial circuits.
Through the “Magic Mirror”: Adapting Angela Carter’s Japanese Writings for the Silver Screen
Authors: Crofts Charlotte 
Published: February 2023

Abstract
This article outlines the development of a feature-length screenplay adaptation of Angela Carter’s short story “Flesh and the Mirror,” situating it within a critical discussion of her metaleptic narrative strategies and the challenges of translating them to the screen. The screenplay incorporates Carter’s Japanese short stories and journalism, which are said to be her most autobiographical writings. The article explores Carter’s attitude to life writing and highlights the dangers of a straightforward biographical adaptation, contextualizing her Japanese writings within her wider engagement with Japanese literature and the I-novel. It demonstrates how the screenplay aims to emulate Carter’s playful experimentation with narrative form, overlapping metaphors of magic mirrors, puppetry, theater, and film sets, attempting a delicate balancing act of transposing Carter’s “literary gymnastics” to the silver screen.
Breeding phase and outcome determine space use in European rollers Coracias garrulus prior to migration
Authors: Monti Flavio , Barišić Sanja , Cannarella Sebastian , Ćiković Davor , Tutiš Vesna , Kralj Jelena , Catoni Carlo 
Published: February 2023

Abstract
The breeding period is a demanding and time-constrained phase for migratory bird species. Breeding outcome and duration can interact with the extent and duration of post-breeding movements, resulting in individual differences in space use ultimately influencing later stages of the annual cycle. We present space-use and home range estimates during the breeding season for 21 European rollers Coracias garrulus tracked between 2018 and 2022, in Italy and Croatia. Using high-resolution spatial GPS data coupled with regular nest-box monitoring, we analyzed differences in space use during the incubation/nestling period versus post-breeding period prior to migration, accounting for the breeding outcome (successful vs. failure). We found that adult movements were strongly reduced during the first phase, whereas increased in the post-breeding phase, especially for failed breeders. Successful breeders remained in the surroundings of the nest site, whereas unsuccessful ones tended to abandon the nest and visit distant areas (up to 500 km) for long periods (60.5 ± 6.2 days). Breeding outcome did not influence the departure date of autumn migration, suggesting that failed breeders used this period for exploratory movements but not for advancing the onset of migration. Such exploratory movements may be functional to prospect and inform settlement decisions in failed breeders in search of new breeding opportunities and may be particularly important in migratory species, which generally have a limited period to gather information prior to autumn migration. The study demonstrates the need to investigate seasonal movements in different populations and the potential importance of prospecting post-breeding movements for long-distance migratory species.
Clinical profiles and intraoperative identification of complex glands in stage I lung adenocarcinoma
Authors: Ding Qifeng , Chen Donglai , Shen Shanshan , Wang Wei , Chen Liangyan , Duan Shanzhou , Chen Yongbing 
Published: February 2023

AbstractOBJECTIVESThis study aimed to investigate the potential of complex glandular patterns (CGP) in lymph node micrometastasis (LNMM) and to determine the clinical beneficiaries in stage I lung adenocarcinoma (LUAD) with CGP. Meanwhile, the feasibility of detecting CGP on frozen section was also evaluated.METHODSWe retrospectively analysed the clinicopathological characteristics of 848 pathologic-stage I LUADs. A logistic regression model and a Cox proportional-hazards model were conducted to define the risk factors for LNMM and survival respectively. Furthermore, 5 pathologists reviewed frozen sections of 100 LUADs independently.RESULTSThe logistic regression model indicated that CGP [odds ratio 3.89, 95% confidence interval (CI) 2.46–6.15; P &lt; 0.001] was an independent predictor of the presence of LNMM. Subgroup analysis revealed that CGP-present/LNMM-positive LUAD had the highest risk of both loco-regional and distant recurrence. Moreover, adequate lymphadenectomy [recurrence-free survival: hazard ratio (HR) 0.61, 95% CI 0.40–0.95; P = 0.028; overall survival: HR 0.64, 95% CI 0.41–0.99; P = 0.043] and adjuvant chemotherapy (recurrence-free survival: HR 0.30, 95% CI 0.18–0.52; P &lt; 0.001; overall survival: HR 0.33, 95% CI 0.19–0.57; P &lt; 0.001) brought survival benefits to CGP-present patients, especially to CGP-present/LNMM-positive subgroup. Across the 5 pathologists, sensitivity ranged from 59 to 68% and specificity ranged from 79 to 83%, with moderate diagnostic agreement and high interobserver agreement for detecting CGP on frozen section.CONCLUSIONSLNMM was more frequently observed in stage I LUAD with CGP. Adequate lymphadenectomy and adjuvant chemotherapy were associated with improved survival in CGP-present patients, especially in CGP-present/LNMM-positive subgroup. Additionally, it is feasible to identify CGP on frozen section intraoperatively.
Solutions to address low response rates in online surveys
Authors: Shiyab Wa’ed , Ferguson Caleb , Rolls Kaye , Halcomb Elizabeth 
Published: February 2023

AbstractOnline surveys are increasingly popular in research given their cost-effectiveness and potential reach. However, low response rates remain a key contributor to bias and the overall quality of results. Having a well-designed survey, providing financial remunerations, sending personalized invitations, offering regular reminders, and using more than one recruitment strategy are evidence-based approaches to improve response rates. Given the potential for illegitimate responses to online surveys, approaches that minimize illegitimate participation are discussed.
Identification, genetic diversity, and pathogenicity ofRalstonia pseudosolanacearumcausing cigar tobacco bacterial wilt in China
Authors: Zhao Qian , Geng Ming-yan , Xia Chang-jian , Lei Ting , Wang Jie , Cao Chang-dai , Wang Jing 
Published: February 2023

AbstractRalstonia pseudosolanacearum, previously known as R. solanacearum species complex (RSSC) phylotypes I and III, is a plant pathogenic bacterium causing significant yield losses in economical crops. In the May of 2020 and 2021, cigar tobacco bacterial wilt was first observed in fields in Danzhou, Hainan Province, China. A total of eight bacterial isolates were isolated and identified as R. pseudosolanacearum with race 1, biovar III by 16S rRNA gene sequencing, Biolog, and host identification. The amino acid sequence showed that Hainan strains and 15 R. pseudosolanacearum reference strains from flue-cured tobacco in Shandong and Guizhou Provinces, all belonged to RS1000 type containing the avrA gene, only Guizhou strains also had the popP1 gene. On the basis of phylotype-specific multiplex PCR amplification, mismatch repair gene and endoglucanase gene-base tree, Hainan strains were identified as phylotype I sequevar 70, and showed stronger pathogenic capabilities on three different varieties than those reference strains. This is the first report of cigar tobacco bacterial wilt caused by R. pseudosolanacearum sequevar 70. The results revealed the diversity of RSSC in Nicotiana tabacum in China and provided useful information regarding the epidemiology of cigar tobacco wilt disease, as well as the breeding for disease resistance in local cigar tobacco.
Evaluation of the Occurrence of Hollows in Trees in Managed Forest in the Eastern Brazilian Amazon
Authors: dos Santos Misael Freitas , Figueiredo Filho Afonso , Gama João Ricardo Vasconcellos , Retslaff Fabiane Aparecida de Souza , da Costa Daniele Lima 
Published: February 2023

Abstract
This study proposed to generate information related to the abundance and the structural characteristics of hollows at the tree and species levels in an area of managed forest in the Amazon. A database was used that was composed of 29,899 trees from thirty-eight species that were inventoried, harvested, and measured in ten annual production units that were managed between 2008 and 2017 in the Tapajós National Forest, state of Pará, Brazil. The data was tabulated and reported in absolute and percentage values. Contingency tables were created to identify patterns of occurrence of hollows in commercial stems. A total of 24% of the harvested trees had hollows in at least one section of the commercial stem, and species had different propensities for hollow occurrence. It was found that the larger the tree diameter the greater the possibility for occurrence of hollows, and these hollows were proportionally larger. Most of the hollows in harvested trees were small. Patterns of occurrence in commercial stem hollows were observed, and these were dependent on tree species and size. Most trees had hollows distributed along the entire stem or only at the base of the stem.
Study Implications: The presence of hollows in managed native forest trees in the Amazon depends on the species, and trees with larger diameters have a greater probability of having hollows. Furthermore, trees with larger diameters have hollows that have larger diameters, lengths, and volumes. Commercial trees have different patterns of hollows along the stem, and these patterns are dependent on tree species and size. The results of this study will contribute to management of trees with hollows in the Amazon Forest as well as to serve as a base for future studies related to this theme.
Evolution of the Growth Hormone Gene Duplication in Passerine Birds
Authors: Rasband Shauna A , Bolton Peri E , Fang Qi , Johnson Philip L F , Braun Michael J 
Published: February 2023

AbstractBirds of the order Passeriformes represent the most speciose order of land vertebrates. Despite strong scientific interest in this super-radiation, genetic traits unique to passerines are not well characterized. A duplicate copy of growth hormone (GH) is the only gene known to be present in all major lineages of passerines, but not in other birds. GH genes plausibly influence extreme life history traits that passerines exhibit, including the shortest embryo-to-fledging developmental period of any avian order. To unravel the implications of this GH duplication, we investigated the molecular evolution of the ancestral avian GH gene (GH or GH1) and the novel passerine GH paralog (GH2), using 497 gene sequences extracted from 342 genomes. Passerine GH1 and GH2 are reciprocally monophyletic, consistent with a single duplication event from a microchromosome onto a macrochromosome in a common ancestor of extant passerines. Additional chromosomal rearrangements have changed the syntenic and potential regulatory context of these genes. Both passerine GH1 and GH2 display substantially higher rates of nonsynonymous codon change than non-passerine avian GH, suggesting positive selection following duplication. A site involved in signal peptide cleavage is under selection in both paralogs. Other sites under positive selection differ between the two paralogs, but many are clustered in one region of a 3D model of the protein. Both paralogs retain key functional features and are actively but differentially expressed in two major passerine suborders. These phenomena suggest that GH genes may be evolving novel adaptive roles in passerine birds.
Age Differences in Everyday Emotional Experience: Testing Core Predictions of Socioemotional Selectivity Theory With the MIVA Model
Authors: Wirth Maria , Voss Andreas , Rothermund Klaus 
Published: February 2023

AbstractObjectivesEmotional aging research is dominated by the idea of age-related improvements that result from shifts in motivation. Socioemotional selectivity theory (SST) proposes that as individuals age, they increasingly favor emotion-related goals and savor positive but avoid negative emotions. Previous age-comparative studies on everyday emotional experience typically were descriptive or studied the processes underlying emotional experience in isolation. We aimed at a more holistic approach to test hypotheses derived from SST regarding age-related differences in general emotional dispositions (i.e., anchoring), emotional reactivity, and emotion regulation by using a computational approach.MethodsWe applied our Model of Intraindividual Variability in Affect (MIVA) to data on everyday emotional experiences in an age-diverse sample (N = 378, age range 14–86 years). Parameter estimations were carried out within a Bayesian framework.ResultsOur results provide partial support for predictions derived from SST. Unexpectedly, anchoring showed a negative age trend, indicating a more positive affect disposition in younger, not older adults. Reactions to pleasant events showed no age trend. Reactivity to unpleasant events was highest in midlife and lower for younger and older adults. Consistent with SST, affect elicited by pleasant events was regulated less strongly by older adults and affect elicited by unpleasant events more strongly.DiscussionAs our results provide only partial support for SST, we revisit the phenomena that are at its foundations and provide suggestions on how to refine the theory.
A Brief Report on Living Arrangements Following Gray Divorce
Authors: Brown Susan L , Lin I-Fen , Mellencamp, PhD Kagan A 
Published: February 2023

Abstract

Objectives
We offer new insights on how older adults in the United States navigate the aftermath of gray divorce (i.e., divorce that occurs among adults aged 50+) by describing their living arrangements upon divorce and tracking the stability of these configurations over time. Living arrangements are important to decipher because they are linked to health, well-being, and longevity.

Methods
Using data from the 1998–2014 Health and Retirement Study, we uncovered patterns of U.S. older adult living arrangements upon divorce (N = 1,057), distinguishing among those who lived alone, lived with others, and lived with a new partner. Multinomial logistic regression models were estimated to assess how individual characteristics (demographics, marital biography, economic resources, health, and social ties) were associated with these configurations. Cumulative survival probabilities gauged the relative stability of these 3 living arrangements.

Results
About half of U.S. adults lived alone upon gray divorce, another one-third lived with others, and the remaining 14% lived with a new partner. Adults living with a new partner tended to exhibit the most advantaged sociodemographic profiles, whereas those living solo or with others were largely comparable. More than 70% of adults experienced a subsequent living arrangement transition if they lived with others upon divorce, versus just 50% of those living alone and only 30% of those with a new partner.

Discussion
After divorce, older adults reside in a range of living arrangements, some of which are more stable than others. Future work should address whether and how these arrangements and their durability are related to postdivorce adjustment.
Tackling the challenges of tectonic tremor localization using differential traveltimes and Bayesian inversion
Authors: Bombardier Madison , Dosso Stan E , Cassidy John F , Kao Honn 
Published: February 2023

SUMMARY
Episodic tremor and slip events in Northern Cascadia produce low-frequency, emergent seismic signals, often referred to as tectonic tremor. Methods designed to locate tremor face two challenges that increase the likelihood of producing low quality catalogues: first, signal arrival and duration are often poorly defined; second, high rates of tremor activity during episodes can cause multiple signals to be indiscernible from each other. In this paper, we present a new method of locating tectonic tremor using differential traveltimes from a waveform-envelope cross-correlation in a grid-based Bayesian inversion. To address the aforementioned challenges, we use a recently developed three-dimensional shear wave velocity model to compute traveltimes, and include processes to remove data outliers, estimate data error statistics, and quantify uncertainties within the Bayesian framework. Although this method is designed for tremor, to test the approach we consider a set of 58 local earthquakes between magnitudes −0.07 and 2.6 in the Southern Vancouver Island region and obtain well-constrained relocations. Residuals between official catalogue values and our relocations are quantized with respect to the 1 km grid resolution of the inversion, and average 2.7 km in epicentre and 5.2 km in depth. Analysis shows that depths of relocations are sensitive to horizontal variations and simplifications in velocity models. We then present our catalogue of tremor events during the 2004 episodic tremor and slip event beneath Southern Vancouver Island, Canada. Median uncertainties of tremor events quantified by 95 per cent credibility interval widths in a 1 km grid are 5 km and 9.km in horizontal and depth directions, respectively (1.2 km and 2.3 km using traditional standard deviation-based uncertainties). Comparison of our catalogue with previously published work demonstrates that our new method yields a good detection rate, a greater degree of epicentral clustering, and better depth resolution of tremor events. Catalogues produced using this new method may help to provide insight into the spatial extent of tremor, especially in depth, by yielding enhanced constraints on source locations on a regional scale.
Mental Health, Food Insecurity, and Economic Hardship among College Students during the COVID-19 Pandemic
Authors: Kim Youngmi , Murphy Jennifer 
Published: February 2023

Abstract
The mental health crisis among college students has become one of the most pressing issues, especially during the pandemic. Researchers discuss food insecurity as one of the leading causes of mental distress. The onset and continued impacts of the COVID-19 pandemic appear to compound food insecurity, economic hardship, and mental health. This study aims to understand the mental health of college students in relation to food insecurity and financial struggles to meet basic living expenses and debts during the pandemic. Authors collected survey data from college students in a public urban university in 2020 and conducted a multiple regression (N = 375). Evidence indicated that mental health became significantly worse after the pandemic onset. Mental health was significantly associated with food insecurity and multiple economic hardships, controlling for prepandemic mental health and other characteristics. The findings affirm that food insecurity and dire levels of economic hardship have devastating effects on the mental health of young adults. The article highlights the long-term implications of mental health affected by basic needs insecurity and the emergent need for integrated services and university–community partnerships.
Conjectural Positivity of Chern–Schwartz–MacPherson Classes for Richardson Cells
Authors: Kumar Shrawan 
Published: February 2023

Abstract
Following some work of Aluffi–Mihalcea–Schürmann–Su for the CSM classes of Schubert cells and some elaborate computer calculations by Rimanyi and Mihalcea, I conjecture that the CSM classes of the Richardson cells expressed in the Schubert basis have nonnegative coefficients. This conjecture was principally motivated by a new product $\square $ coming from the Segre-SM classes in the cohomology of flag varieties (such that the associated Gr of this product is the standard cup product) and the conjecture that the structure constants of this new product $\square $ in the standard Schubert basis have alternating sign behavior. I prove that this conjecture on the sign of the structure constants of $\square $ would follow from my above positivity conjecture about the CSM classes of Richardson cells.