bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic expressions of a novel mutation in the MYH7 gene responsible for hypertrophic cardiomyopathy in Pune population
Authors: A. Jagtap Padmapani , A. Mansuri Mosin , Rathod Dnyaneshwar , B. Chavan Chandrakant , W. Wankhade Varsha 
Published: April 2023

Introduction and Aim: Hypertrophic cardiomyopathy (HCM) are the most common kind of cardiac disease that causes left ventricular asymmetric hypertrophy (LVH) or right ventricular hypertrophy (RVH) and non-dilated ventricular chambers. Heterozygous mutation in the MYH7 gene on chromosome 14 causes Left ventricular hypertrophy. The objective of our study was to unravel the mutation spectrum in HCM positive patients and find out novel mutation in MYH7 gene and the impact of these mutations on the pathophysiology of cardiac functioning.

Materials and Methods: Identification and confirmation of HCM patients was done on the basis of the thickness of the Interventricular septum and Left ventricular wall ( >13mm ; >15mm ). Extraction of DNA from the whole blood of HCM patients and healthy population using the standard phenol- chloroform extraction method was carried out. Polymerase Chain Reaction (PCR) was performed, and samples were processed for Sanger sequencing. Alter the structural arrangement and characteristics of respective mRNAs software’s RNA Fold Web server.

Results: We found a novel mutation in the MYH7 gene, which could cause phenotypic expressions similar to that of HCM.

Conclusion: Mutation in the gene may be responsible for causing hypertrophic cardiomyopathy. The mutations reported in our study, are responsible to alter the structural arrangement and characteristics of respective mRNAs.
Prevalence and antibiogram of non-urinary isolates among patients attending a tertiary care hospital
Authors: Naz Ruby , Sangwan Jyoti , J. Ramalingam Aishwarya , Khan Sameena 
Published: April 2023

Introduction and Aim: Gram-negative bacterial infections have emerged as a global health problem in clinical care. They account for the majority of community and hospital acquired infections which are resistant to various antimicrobials. The present study aimed to investigate the prevalence and antibiotic susceptibility pattern of Gram-negative bacteria (GNB) isolated from various non-urinary samples at a tertiary care hospital in Haryana.

Materials and Methods: A total of 228 isolates were obtained from various clinical samples from January 2018 to July 2018 and were identified by standard bacteriological techniques. Antibiotic susceptibility testing was done using the disc diffusion technique by the Kirby Bauer method.

Results: Adult patients showed higher isolation of GNB (31%) as compared to paediatric patients (16.3%). The most common GNB isolated from blood was Pseudomonas spp.(62%) and Klebsiella spp.(66.7%) from respiratory samples isolated in our study showed resistance to common antibiotics like gentamicin and ceftriaxone. Polymyxin B and Tigecycline were found to be sensitive.

Conclusion: Strict compliance with antimicrobial stewardship policy should be followed to reduce the menace of antibiotic resistance.
Role of CTLA-4, PD-1 and PD-L1 immune biomarkers among HCV patients undergoing hemodialysis
Authors: S. Jouda Ryiam , M. Ibrahim Basim , F. Al-Khafagi Ahmed 
Published: April 2023

Introduction and Aim: One of the most prevalent diseases seen in Iraqi patients undergoing hemodialysis treatment for chronic renal disease is hepatitis C virus, also known as HCV infection (CKD). In this study, we intended to determine whether immune checkpoint biomarkers such as CTLA-4, PD-1, and PD-L1 might be utilized to predict the outcome for hemodialysis patients who had HCV infection and CKD.

Materials and Methods: The study comprised 90 Iraqi patients. The participants were separated into three groups: Group I (control group) consisted of those without viral infection. Group II consisted of 30 HCV-infected patients who did not receive antiviral medication, whereas Group III consisted of 30 HCV-infected patients who had had recent/previous antiviral drug treatment. ELISA was used to evaluate the serum predictive values of immunological biomarkers in all three groups of people. The collected results were statistically analyzed.

Results: Serum levels of the measured biomarkers were seen elevated among all individuals in Group I and II showing a high statistically significant difference between patients’ group and healthy controls. The area under the curve (AUC) for CTLA-4, PD-1, and PD-L1 was 93%, 99%, and 96%, respectively.

Conclusion: The prognostic factor-value of immune biomarkers investigated in this study could be used as predictors in patients with CKD and infected with HCV.
Belimumab (Benlysta)
Authors: CADTH  
Published: April 2023

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses belimumab 400 mg per 20 mL vial and 120 mg in 5 mL vial lyophilized powder for IV infusion.
Indication: Indicated in addition to standard therapy for the treatment of active lupus nephritis in adult patients.
Consideraciones a propósito de terkininei y eskenim del bronce de Torrijo [TE.03.01] y el uso del sistema dual de escritura en celtibérico
Authors: Jordán Cólera Carlos 
Published: April 2023

El autor plantea nuevas interpretaciones fonéticas para dos palabras que aparecen en el bronce celtibérico de Torrijo: terkininei y eskenim. A partir de ellas explora nuevas posibilidades morfo-etimológicas. Para terkininei propone [tregnīney], dativo singular de un posible tema en -i *tregnīnis. eskenim podría leerse [eχskenim] y caben, al menos, dos interpretaciones morfo-etimológicas: *egʰs-ken-is o *egʰs-kenh1-is. Se comentan también otras formas cercanas como eskeinis, eskeninum, genis y gentis. Finalmente realiza una serie de reflexiones sobre el sistema dual de escritura en varios documentos celtibéricos.
A REVIEW OF ARTIFICIAL INTELLIGENCE (AI) CHALLENGES AND FUTURE PROSPECTS OF EXPLAINABLE AI IN MAJOR FIELDS: A CASE STUDY OF NIGERIA
Authors: Mohammed K. , Shehu A. 
Published: April 2023

Artificial intelligence (AI) has been used widely in essential fields such as energy, health, agriculture, finance etc. However, Artificial intelligence is still faced with social, ethical, legal, and technological challenges. It is important to know how these systems make their decisions while still achieving and implementing the benefits of AI. Explainable AI (XAI) is a technique that is used to explain how a machine made a decision. In this review, we discuss the challenges of AI and recommend XAI as a tool to solve the limitations of AI and suggest a human and conditions-based approach to challenges faced in the technology in Nigeria. This paper employs a narrative review to highlight problems that are limiting the use of AI in four important sectors of Nigeria: Health, Energy, Agriculture, and Finance, and suggest recommendations to solve the AI challenges. The review data was obtained from journals and researchers. We discuss Explainable AI (XAI) as a technique for solving challenges like trustworthiness, bias, lack of data, expertise, and confidence in using AI in major sectors. The paper focuses on the users, conditions, and challenges and recommends that humans and conditions be taken into consideration when building XAI systems.
Kontras Manusia Langit dan Bumi dalam Novel Manusia Langit Karya J.A. Sonjaya: Perbandingan Kehidupan Sosial Masyarakat Desa dan Kota
Authors: Nisa Iis Khoerun , Wasono Sunu 
Published: April 2023

Regional issues can inspire authors to create literature. From the very beginning of its birth, modern Indonesian literature began to lift the local color that was marked by the Minangkabau cultural-themed novel. Along its development, problems of the region that had never been discovered before by authors. Into the 21st century, literature that established paganism kept on the rise. Among other things, it was marked by the appearance of Sonjayaâ€™s Manusia Langit novel, published in 2010. It brought the problems of social life in Nias society to the surface. An interesting aspect of the Manusia Langit novel, the people of Nias, stand in stark contrast with urban society. The study aims to expose the contrast between Nias (manusia bumi) and urban people (manusia langit) as described in Jajang Agus Sonjayaâ€™s novel Manusia Langit. The author examines Manusia Langitâ€™s novel through a literary sociology approach using qualitative descriptive methods to achieve this goal. The studyâ€™s result found three contrasts in this novel: the contrast between leadership and culture, the contrast of position in society, and the contrast of education. Â Berbagai persoalan kedaerahan dapat mengilhami pengarang untuk menciptakan karya sastra. Sejak awal kelahirannya, sastra Indonesia modern mulai mengangkat warna lokal yang ditandai dengan kemunculan novel bertema budaya Minangkabau. Seiring dengan perkembangannya, problem-problem daerah yang belum pernah tersentuh turut disingkap oleh para pengarang. Hingga abad ke-21, karya sastra yang mengangkat kedaerahan tetap marak bermunculan. Hal itu antara lain ditandai dengan munculnya novel Manusia Langit karya Sonjaya yang terbit pada tahun 2010. Novel ini mengangkat persoalan kehidupan sosial masyarakat Nias. Terdapat aspek yang menarik untuk dikaji dalam novel Manusia Langit, yaitu masyarakat Nias digambarkan secara kontras dengan masyarakat kota. Kajian ini bertujuan untuk mengungkapkan kontras masyarakat Nias (manusia bumi) dan masyarakat kota (manusia langit) yang digambarkan dalam novel Manusia Langit karya Jajang Agus Sonjaya. Untuk mencapai tujuan ini, penulis mengkaji novel Manusia Langit melalui pendekatan sosiologi sastra dengan menggunakan metode deskriptif kualitatif. Hasil penelitian menunjukkan bahwa terdapat tiga kontras yang digambarkan dalam novel Manusia Langit yang mencakup kontras kepemimpinan dan budaya, kontras kedudukan dalam masyarakat, dan kontras pendidikan.
A Metrico-Stylistic Trait of Aural Punctuation in Old English Verse
Authors: Fulk R. D. 
Published: April 2023

ABSTRACT
Starting from an idea proposed by Barbara C. Raw, this paper explores the distribution of Eduard Sievers’s five metrical types of verses in instances of so-called aural punctuation in Old English poetry. In aural punctuation, a lone and syntactically independent off-verse is used to mark the end of a passage and a change of subject. One finding is that verses of type A are generally disfavored as aural punctuation. Another is that there is a general correlation between the rate of incidence of aural punctuation in a poem and its probable date of composition, aural punctuation becoming less common over time.
O DIÁLOGO DAS ARTES: A POESIA DE HELOÍSA PRAZERES E A FOTOGRAFIA DE JAMISON PEDRA
Authors: FONSECA ALEILTON 
Published: April 2023

RESUMO: As diversas formas artísticas podem-se associar, imbricando-se no conjunto de imaginários que compõe a consciência do sujeito, o seu conteúdo mental e as suas referências mnemônicas. Entre essas artes, a poesia e a fotografia muitas vezes se cruzam na experiência criativa dos autores. Neste ensaio, temos como objetivo demostrar as aproximações e correspondências entre a poesia de Heloísa Prazeres e a fotografia de Jamison Pedra. Para tanto, comparamos poemas e fotos inseridos nos seus livros, para identificar pontos de convergência de sentidos que compartilham enquanto representações artísticas. Observamos que os poemas e as fotografias estabelecem, de forma integrada e interrelacionada, um feixe de leituras imagéticas plurais, representando viagens, registros, passagens, projeções, decifrações. Por este caminho, Heloísa Prazeres realiza a poiesis das imagens que capta em suas itinerâncias. Enquanto isso, Jamison Pedra realiza o registro estético das imagens, recortando-as do universo empírico e revestindo-as de uma poiesis da fotografia, em preto e branco, como objeto de arte.
Palavras-chave: Poesia; Fotografia; Correspondência das artes
LUGARES E POSIÇÕES ATRIBUÍDOS DISCURSIVAMENTE À ESCOLA, À DISCIPLINA LÍNGUA PORTUGUESA, AO PROFESSOR E AO ALUNO NO PROCESSO AVALIATIVO
Authors: Da Silva Rocha Adenilton , Fabiano Campos Sulemi 
Published: April 2023

Neste estudo, objetivamos investigar as imagens que são construídas discursivamente da escola, da disciplina Língua Portuguesa, do professor e do aluno na seção “avaliação” de planos de curso da disciplina Língua Portuguesa. Analisamos os lugares e as posições que são atribuídos aos sujeitos, bem como a referida disciplina nos respectivos documentos escolares. Os planos de curso foram selecionados de duas escolas municipais do Extremo Sul da Bahia, localizadas em Medeiros Neto e Nova Viçosa. Fundamentamos a pesquisa nos estudos de Pêcheux (2014) – condizentes aos mecanismos do funcionamento discursivo e às formações imaginárias –, Libâneo (1992) – referentes ao planejamento pedagógico – e de Antunes (2003) – concernentes à avaliação escolar. Como metodologia, utilizamos o método “paradigma indiciário” (GINZBURG, 1989). Primeiramente, descrevemos o conteúdo mobilizado na seção “avaliação” e, em seguida, examinamos o nível discursivo. Os discursos predominantes na tessitura do texto indicaram as seguintes imagens: a escola e a disciplina Língua Portuguesa como lugares de controlar o trabalho docente e o comportamento do aluno; o professor é o responsável pelo desempenho e fiscal da conduta do aluno; já o aluno é indisciplinado, submisso ao comando do professor e responsável pelo seu próprio rendimento. Esse conjunto de imagens sinalizou os resquícios da avaliação tradicional no planejamento, na qual são desconsideradas as singularidades dos sujeitos que compõem o contexto escolar.
Palavras-chave: Avaliação; Discurso; Ensino de Língua Portuguesa; Imagens.
Predicting mortality in children with confirmed or suspected COVID-19
Authors: Khan Hafiz Sajid , Malik Farhat R. , Khan Muhammad Zeeshan , Fiaz Ilyas , Waheed Zahra Mannan , Jadoon Sofia , Jamil Muhammad , Sharma Ravi Dutt 
Published: April 2023

Introduction: Coronavirus disease 2019 (COVID-19) is spreading quickly and killing people across the board, including infants. The risk variables that indicate infant death are still uncertain, though. Examining risk signs for babies with COVID-19 was the aim of this study. Methods: Secondary data analysis was performed using provincial COVID-19 data from September 2021 to December 2022. For this study, 1000 children under the age of 18 were selected. In order to investigate the factors that led to fatalities in children diagnosed with COVID-19, chi-square analysis and binary logistic regression were utilized. Results: According to this research, the frequency of infants dying from COVID-19 was 6.7%. Age, case classification, therapy state, disease intensity, and trip experience all significantly correlated with toddlers infected with the COVID-19 virus’s mortality rate. Age affects the likelihood of succumbing from COVID-19 (Adjusted odd ratio (AOR) =0.92; CI 95%=0.93-0.98). In addition, using ventilators while in the ICU (AOR=22.45; 95% CI=5.86-86.33), serious sickness (AOR=46.23; 95% CI=21.33-100.63), and travel history (AOR=1.87; 95% CI=1.92-2.83) were all clearly linked to a greater chance of mortality in kids with the COVID-19. Conclusion: The greatest predictor of mortality was childhood illness that was serious.
Tanthawi Jauharis Interpretation of Earthquakes Verses
Authors: Naqiya Hilya Nuri , Purwati Puji , Nur Asifa Vina , Huda Nurul , Aulia Questyanda 
Published: April 2023

Abstract
[Tantawi Jauhari's Interpretation of Earthquakes Verses] This article discusses the moving earth which often causes earthquakes. Earthquakes are generally caused by the movement of the earth's plates, volcanic eruptions, natural events and non-natural factors. In the Qur'an there are names of earthquakes including zalzalah, dakk, rajj, and Rajfah. So the author feels the need to explore the interpretation related to earthquakes by one of the science commentators, namely Tantawi Jauhari. This article uses a qualitative method with a library research approach. The data collection technique uses search techniques. This article finds that the verses of the Qur'an are facts that support scientific theories that are currently developing. And the finding of conformity of the explanation of the Qur'an with terms related to earthquakes. This article aims to add insight into knowledge related to earthquakes in the Qur'an and interpretations about it.
Keywords
Earthquake — Interpretation— Tantawi Jauhari

ملخص
[تفسير طنطاوي الجوهري لآيات الزلازل] يناقش هذا المقال حركة الأرض التي تسبب الزلازل غالبًا. تحدث الزلازل بشكل عام بسبب حركة صفائح الأرض والانفجارات البركانية والأحداث الطبيعية والعوامل غير الطبيعية. ورد في القرآن أسماء الزلازل بما في ذلك منها الزلزلة، الودق، الرج ، والرجفة. لذلك يشعر المؤلف بضرورة استكشاف تفسير الزلازل من قبل أحد المفسرين العلميين وهو طنطاوي الجوهري. تستخدم هذه المقالة طريقة نوعية مع نهج بحث المكتبة. تستخدم تقنية جمع البيانات تقنيات البحث. تجد هذه المقالة أن آيات القرآن هي حقائق تدعم النظريات العلمية التي يتم تطويرها حاليًا. وإيجاد تطابق تفسير القرآن مع المصطلحات المتعلقة بالزلازل. تهدف هذه المقالة إلى إضافة نظرة ثاقبة إلى المعرفة المتعلقة بالزلازل في القرآن والتفسيرات المتعلقة بها.
الكلمات المفتاحية
الزِلزال – التفسير – طنطاوي جوهري

Abstrak
[Penafsiran Tantawi Jauhari tentang Ayat-ayat Gempa bumi] Artikel ini membahas mengenai bumi yang bergerak yang sering menimbulkan gempa bumi. Gempa bumi pada umumnya disebabkan oleh pergesaran lempeng bumi, letusan gunung berapi, kejadian alam dan faktor non alam. Dalam Al-Qur’an terdapat nama-nama gempa di antaranya zalzalah, dakk, rajj, dan rajfah. Sehingga penulis merasa perlu mendalami penafsiran terkait gempa bumi oleh salah satu mufassir sains yaitu Tantawi Jauhari. Artikel ini menggunakan metode kualitatif dengan pendekatan kajian pustaka (library research). Adapun teknik pengumpulan data menggunakan teknik penelusuran. Artikel ini menemukan bahwa ayat-ayat Al-Qur’an menjadi fakta pendukung teori sains yang berkembang saat ini. Dan ditemukannya kesesuaian penjelasan Al-Qur’an dengan istilah-istilah terkait gempa. Artikel ini bertujuan untuk menambah wawasan pengetahuan terkait gempa bumi dalam Al-Qur’an serta penafsiran mengenai hal tersebut.
The Effectiveness of the STEM Project Based Learning Approach in Physics Learning to Improve Scientific Work Skills of High School Students
Authors: Berry Devanda  , Lufri  , Elizar Elizar 
Published: April 2023

This study aims to improve students' scientific work skills by using a STEM-integrated Project Based Learning approach with simple water wheel props on energy and work in class X high school physics learning. The method used is classroom action research. The research was carried out in two cycles in class X SMA Negeri 1 Koto XI Tarusan on the material of work and energy by making a water wheel project. Aspects of students' scientific work skills observed were skills in asking questions, planning experiments, making observations, using tools/materials, analyzing experimental results, making conclusions, compiling experimental reports, and presentation skills. In the first cycle, students' work scientific skills were 64.35%, while in the second cycle, they were 78.5%. In addition to scientific work skills, students' conceptual knowledge also increased by 9.15%. The conclusion from this study is that the application of the STEM-integrated Project Based Learning approach with the waterwheel props can improve students' scientific skills. The STEM-integrated Project Based Learning approach with effective waterwheel teaching aids to improve students' scientific skills on energy and work materials in physics learning.

Keywords: Scientific Work Skills, Physics, Project Based Learning, STEM
Impact Site Tiktok Beauty Vloggers To Behavior Imitation Students Of The Faculty Of Dakwah
Authors: Mutiawati  , Elsa Fitria Anwar  , Fina Jamaluddin Hasibuan  , Andini Nur Bahri  
Published: April 2023

Tiktok is a site that is frequently used by the general public for information, entertainment, and a source of talent and talent. Various types of content continue to be created, one of which is beauty vlogger content which is very popular among women. The purpose of this study is to find out how the effects of beauty shows are vloggers on the Tiktok site for imitating or imitating behavior and how big the effect it is for students majoring in Communication Studies class of 2020 at the State Islamic University of North Sumatra. The type of research being carried out was descriptive qualitative using observation and interview techniques with several students majoring in preaching dan communication science class of 2020 at the State Islamic University of North Sumatra. The results of this study indicate that beauty vloggers on the Tiktok site have the same effect on informants, namely a pleasant effect on the information they get, entertain them, and get self-satisfaction with the beauty shows they see. They generate imitation behavior in the form of plagiarizing makeup tutorial videos, recommending videos they watch to others and buying the same products.
Student’s Experiences on Their Thesis Proposal Seminar
Authors: Sugeng Pradikto  
Published: April 2023

This study aims to investigate students’ experiences based on their thesis proposal seminar for Economic Education Students’ Department Study Program at Universitas PGRI Wiranegara. The researcher used the questionnaire to get the data from the students’ experiences based on their thesis proposal seminar at three stages, starting from the beginning up to the end. Based on the result shown that for the first table explained before the thesis proposal seminar presentation exposed that most students’ good understanding of the learning objective of the seminar course (83,3%) and that they felt confident and supported by many resources. For the second table explained during the seminar session, most students agree (70,9%) that seminar encouraged their ideas to share and learn from others, but (45,8%) disagree that group discussion in a presentation session seminar is better than lecturing. The last table explained after the seminar session, showed the students that (93,8%) believe that post-seminar questions and feedback are informative both from lectures and from their friends, also (70,8%) agree that the seminar success through good preparation, and (81,3%) that classmates’ participation supported the seminar’s success.
Competencia informacional para la actividad traductora
Authors: Ortoll Espinet Eva 
Published: April 2023

En el procés de traducció existeixen tasques que requereixen l’ús d’informació. D’altra banda, la tecnologia ha originat noves formes de treballar que influeixen en la manera d’utilitzar la informació. Entre les diferents competències vinculades al desenvolupament de l’activitat traductora, es discuteix la importància de la competència informacional. competència informacional; competència traductora; alfabetització digital; habilitats informacionals.