bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIALOGANDO COM AS MODALIDADES DE PRÁTICAS DE ESTÁGIO CURRICULAR SUPERVISIONADO EM MATEMÁTICA
Authors: Sakai Edinalva da Cruz Teixeira , Pereira Patrícia Sandalo 
Published: March 2023

O objetivo deste artigo é apresentar os principais resultados da pesquisa de mestrado “Um panorama das pesquisas sobre as Práticas de Estágio Curricular Supervisionado em Matemática nas regiões Norte, Nordeste e Centro-Oeste do Brasil”. O trabalho em questão buscou evidenciar, por meio das dissertações e teses desenvolvidas nos programas de Pós-Graduação em Educação Matemática dessas três regiões, as modalidades de práticas de Estágio Curricular Supervisionado em Matemática. Do mapeamento, tomamos como corpus de estudo oito pesquisas, das quais emergiram as seguintes categorias de análises: a) Prática como experiência; b) Práticas colaborativas; c) Práticas reflexivas e d) Práticas promotoras de desenvolvimento profissional. As análises, baseadas nospressupostos da Metanálise, revelaram que o Estágio Curricular Supervisionado na perspectiva da prática pela prática ou da experiência pela experiência pode ficar restrito a uma atividade puramente técnica, burocratizada, apontando para uma urgente necessidade de redefinir-se o modelo atual dos estágios por projetos que valorizem as práticas colaborativas e reflexivas, favoráveis ao desenvolvimento profissional não apenas dos futuros professores como também dos demais atoresenvolvidos nesse processo formativo.
ABORDAGEM DOCUMENTAL DO DIDÁTICO E O ENSINO DE EQUAÇÃO DO 1º GRAU NA EDUCAÇÃO DE JOVENS E ADULTOSENSINO MÉDIO
Authors: Júnior Severino Ramos Nunes Machado , Espíndola Elisângela Bastos de Mélo , Trgalova Jana , Luberiaga Elida 
Published: March 2023

Apresentamos uma análise sobre o trabalho documental de um estudante-estagiário da licenciatura em matemática e de um professor-supervisor de estágio, no processo de preparação eimplementação de uma aula sobre equação do 1º grau, no Ensino Médio da Educação de Jovens e Adultos. Tomamos como principal suporte teórico a Abordagem Documental do Didático (GUEUDET; TROUCHE, 2010), na qual a construção de um documento se faz a partir de um conjunto de recursos por apropriação e transformação pelo professor. Desta forma, em um período de dois meses, em uma escola pública da rede estadual de Pernambuco, ocorreu o acompanhamento do estágio do estudante, organizado em três momentos: antes, durante e depois de sua aula; pelos quais,buscamos levantar e analisar a utilização dos recursos em jogo do professor-supervisor e do estagiário para o ensino de equação do 1º grau. Os resultados do estudo apontam perspectivas teóricometodológicas para o desenvolvimento de pesquisas no campo da formação inicial docente, em particular, nas disciplinas do estágio supervisionado, pelo viés da investigação reflexiva, acerca do uso de recursos, a exemplo de balança virtual, sites, ficha de exercícios.
RELAÇÕES ENTRE O RACIOCÍNIO COMBINATÓRIO E O RACIOCÍNIO PROBABILÍSTICO NA EJA
Authors: Lima Ewellen Tenorio de , Borba Rute Elizabete de Souza Rosa 
Published: March 2023

No presente texto, são discutidos os resultados de um estudo piloto de uma pesquisa de mestrado que buscou investigar as contribuições que a exploração de problemas combinatórios podetrazer para o raciocínio probabilístico e vice-versa. À luz da Teoria dos Campos Conceituais, foram consideradas, na construção do instrumento de coleta e no desenvolvimento do estudo, as diferentes situações que atribuem sentido à Combinatória e à Probabilidade, bem como as relações entre os conceitos de tais áreas da Matemática. A coleta de dados consistiu na proposição de oito problemas combinatórios (divididos em quatro blocos: produto cartesiano, arranjo, permutação e combinação) revisitados sob o olhar da Probabilidade a partir de 20 problemas (cinco referentes a cada bloco combinatório), em contexto de entrevistas clínicas individuais. Participaram do estudo oito estudantes da Educação de Jovens e Adultos, cursando os Módulos I, II, III e IV (equivalentes aos Anos Iniciais e Anos Finais do Ensino Fundamental). A partir dos dados analisados, perceberam-se contribuições que surgem da resolução de problemas que relacionam Combinatória e Probabilidade, sendo o desempenho dos participantes diretamente influenciado pela escolaridade e pela idade dos mesmos. Defende-se, assim, que a articulação entre Combinatória e Probabilidade pode beneficiar o desenvolvimento de ambos os raciocínios em questão na EJA.
Cervicovaginal mucus barrier properties during pregnancy are impacted by the vaginal microbiome
Authors: Zierden Hannah C. , DeLong Kevin , Zulfiqar Fareeha , Ortiz Jairo Ortiz , Laney Victoria , Bensouda Sabrine , Hernández Nicole , Hoang Thuy M. , Lai Samuel K. , Hanes Justin , Burke Anne E. , Ensign Laura M. 
Published: March 2023

IntroductionMucus in the female reproductive tract acts as a barrier that traps and eliminates pathogens and foreign particles via steric and adhesive interactions. During pregnancy, mucus protects the uterine environment from ascension of pathogens and bacteria from the vagina into the uterus, a potential contributor to intrauterine inflammation and preterm birth. As recent work has demonstrated the benefit of vaginal drug delivery in treating women’s health indications, we sought to define the barrier properties of human cervicovaginal mucus (CVM) during pregnancy to inform the design of vaginally delivered therapeutics during pregnancy.MethodsCVM samples were self-collected by pregnant participants over the course of pregnancy, and barrier properties were quantified using multiple particle tracking. 16S rRNA gene sequencing was performed to analyze the composition of the vaginal microbiome.ResultsParticipant demographics differed between term delivery and preterm delivery cohorts, with Black or African American participants being significantly more likely to delivery prematurely. We observed that vaginal microbiota is most predictive of CVM barrier properties and of timing of parturition. Lactobacillus crispatus dominated CVM samples showed increased barrier properties compared to polymicrobial CVM samples.DiscussionThis work informs our understanding of how infections occur during pregnancy, and directs the engineering of targeted drug treatments for indications during pregnancy.
Hypercapsule is the cornerstone of Klebsiella pneumoniae in inducing pyogenic liver abscess
Authors: Hu Dakang , Chen Wenjie , Wang Weiwen , Tian Dongxing , Fu Pan , Ren Ping , Mu Qing , Li Gang , Jiang Xiaofei 
Published: March 2023

PurposeTo investigate the mechanisms of Klebsiella pneumoniae-induced pyogenic liver abscess (PLA).MethodsForty-three K. pneumoniae strains from PLAs and 436 from non-PLAs were collected. Their differences were compared for virulence genes and factors, sequence types, and serotypes. Virulence genes wzi, wzy-K1, and wzi+wzy-K1 were deleted in K. pneumoniae NTUH-K2044. Various analyses, such as transmission electron microscopy, neutrophil killing tests, and mouse lethality tests, were used to confirm the consequent changes.ResultsDifferences were found between K. pneumoniae strains from PLA and non-PLA samples for virulence genes and factors, including metabolism genes (allS and peg-344), capsular polysaccharide (CPS)-synthesis channel gene (wzy-K1), CPS-regulating genes (p-rmpA, p-rmpA2, and c-rmpA), and siderophore genes (iucA and iroN). When wzy-K1 was positive, the difference between PLA and non-PLA samples was only observed with c-rmpA. Δwzi, Δwzy-K1, and ΔwziΔwzy-K1 strains reverted to hypovirulence. In the Kupffer cell stimulation assay, interleukin (IL)-6, IL-12, IL-10, and transforming growth factor-β secretions were found to be equivalent in NTUH-K2044, Δwzi, Δwzy-K1, and ΔwziΔwzy-K1 groups. Lower IL-1β and higher tumor necrosis factor-α secretions were observed for Δwzi, Δwzy-K1, and ΔwziΔwzy-K1.ConclusionsHypercapsule production is the cornerstone of hypervirulence, regardless of exopolysaccharides. K1 K. pneumoniae-induced PLA may decrease core inflammatory cytokines rather than increase anti-inflammatory cytokines. Exopolysaccharides could also attenuate the inflammatory response to aid in the immune escape of K. pneumoniae.
Assessing the effect of dialogue on altruism toward future generations: A preliminary study
Authors: Maalouly Elie , Yamazaki Ryuji , Nishio Shuichi , Nørskov Marco , Kamaga Kohei , Komai Shoji , Chiba Kiyoshi , Atsumi Keiichiro , Akao Ken-Ichi 
Published: March 2023

IntroductionDespite the abundance of evidence on climate change and its consequences on future generations, people, in general, are still reluctant to change their actions and behaviors toward the environment that would particularly benefit posterity. In this study, we took a preliminary step in a new research direction to explore humans' altruistic behavior toward future generations of people and whether it can be affected by dialogue.MethodsWe used an android robot called Telenoid as a representative of future generations by explaining that the robot is controlled by an Artificial Intelligence (AI) living in a simulation of our world in the future. To measure people's altruistic behavior toward it, we asked the participants to play a round of the Dictator Game with the Telenoid before having an interactive conversation with the Telenoid and then playing another round.ResultsOn average, participants gave more money to the Telenoid in the second round (after having an interactive conversation). The average amount of money increased from 20% in the first to about 30% in the second round.DiscussionThe results indicate that the conversation with the robot might have been responsible for the change in altruistic behavior toward the Telenoid. Contrary to our expectations, the personality of the participants did not appear to have an influence on their change of behavior, but other factors might have contributed. We finally discuss the influence of other possible factors such as empathy and the appearance of the robot. However, the preliminary nature of this study should deter us from making any definitive conclusions, but the results are promising for establishing the ground for future experiments.
Causal relationship between type 1 diabetes mellitus and six high-frequency infectious diseases: A two-sample mendelian randomization study
Authors: Chen Xiao-Hong , Liu Hong-Qiong , Nie Qiong , Wang Han , Xiang Tao 
Published: March 2023

PurposeType 1 diabetes mellitus (T1DM) is associated with different types of infections; however, studies on the causal relationship between T1DM and infectious diseases are lacking. Therefore, our study aimed to explore the causalities between T1DM and six high-frequency infections using a Mendelian randomization (MR) approach.MethodsTwo-sample MR studies were conducted to explore the causalities between T1DM and six high-frequency infections: sepsis, acute lower respiratory infections (ALRIs), intestinal infections (IIs), infections of the genitourinary tract (GUTIs) in pregnancy, infections of the skin and subcutaneous tissues (SSTIs), and urinary tract infections (UTIs). Data on summary statistics for T1DM and infections were obtained from the European Bioinformatics Institute database, the United Kingdom Biobank, FinnGen biobank, and Medical Research Council Integrative Epidemiology Unit. All data obtained for summary statistics were from European countries. The inverse-variance weighted (IVW) method was employed as the main analysis. Considering the multiple comparisons, statistical significance was set at p&lt; 0.008. If univariate MR analyses found a significant causal association, multivariable MR (MVMR) analyses were performed to adjust body mass index (BMI) and glycated hemoglobin (HbA1c). MVMR-IVW was performed as the primary analysis, and the least absolute shrinkage and selection operator (LASSO) regression and MVMR-Robust were performed as complementary analyses.ResultsMR analysis showed that susceptibility to IIs increased in patients with T1DM by 6.09% using the IVW-fixed method [odds ratio (OR)=1.0609; 95% confidence interval (CI): 1.0281–1.0947, p=0.0002]. Results were still significant after multiple testing. Sensitivity analyses did not show any significant horizontal pleiotropy or heterogeneity. After adjusting for BMI and HbA1c, MVMR-IVW (OR=1.0942; 95% CI: 1.0666–1.1224, p&lt;0.0001) showed significant outcomes that were consistent with those of LASSO regression and MVMR-Robust. However, no significant causal relationship was found between T1DM and sepsis susceptibility, ALRI susceptibility, GUTI susceptibility in pregnancy, SSTI susceptibility, and UTI susceptibility.ConclusionsOur MR analysis genetically predicted increased susceptibility to IIs in T1DM. However, no causality between T1DM and sepsis, ALRIs, GUTIs in pregnancy, SSTIs, or UTIs was found. Larger epidemiological and metagenomic studies are required to further investigate the observed associations between the susceptibility of certain infectious diseases with T1DM.
Clinical characteristics and risk factors of lower extremity amputation in the diabetic inpatients with foot ulcers
Authors: Gong Hongping , Ren Yan , Li Zhenyi , Zha Panpan , Bista Raju , Li Yan , Chen Dawei , Gao Yun , Chen Lihong , Ran Xingwu , Wang Chun 
Published: March 2023

ObjectivesTo analyze clinical characteristics of the diabetic inpatients with foot ulcers and explore the risk factors of lower extremity amputation (LEA) in West China Hospital of Sichuan University.MethodsA retrospective analysis was performed based on the clinical data of the patients with diabetic foot ulcer (DFU) hospitalized in West China Hospital of Sichuan University from January 1, 2012 to December 31, 2020. The DFU patients were divided into three groups: non-amputation, minor amputation, and major amputation groups. The ordinal logistic regression analysis was used to identify the risk factors for LEA.Results992 diabetic patients (622 males and 370 females) with DFU were hospitalized in the Diabetic Foot Care Center of Sichuan University. Among them, 72 (7.3%) (55 minor amputations and 17 major amputations) cases experienced amputation, and 21(2.1%) refused amputation. Excluding the patients who refused amputation, the mean age and duration of diabetes of and HbA1c the 971 patients with DFU, were 65.1 ± 12.3 years old, 11.1 ± 7.6 years, and 8.6 ± 2.3% respectively. The patients in the major amputation group were older and had longer course of diabetes for a longer period of time than those in the non-amputation and minor amputation groups. Compared with the non-amputation patients (55.1%), more patients with amputation (minor amputation (63.5%) and major amputation (88.2%)) suffered from peripheral arterial disease (P=0.019). The amputated patients had statistically lower hemoglobin, serum albumin and ankle brachial index (ABI), but higher white blood cell, platelet counts, fibrinogen and C-reactive protein levels. The patients with amputation had a higher incidence of osteomyelitis (P = 0.006), foot gangrene (P &lt; 0.001), and a history of prior amputations (P &lt; 0.001) than those without amputation. Furthermore, a history of prior amputation (odds ratio 10.194; 95% CI, 2.646-39.279; P=0.001), foot gangrene (odds ratio 6.466; 95% CI, 1.576-26.539; P=0.010) and ABI (odds ratio 0.791; 95% CI, 0.639-0.980; P = 0.032) were significantly associated with LEAs.ConclusionsThe DFU inpatients with amputation were older with long duration of diabetes, poorly glycemic control, malnutrition, PAD, severe foot ulcers with infection. A history of prior amputation, foot gangrene and a low ABI level were the independent predictors of LEA. Multidisciplinary intervention for DFU is essential to avoid amputation of the diabetic patients with foot ulcer.
Laughter yoga as an enjoyable therapeutic approach for glycemic control in individuals with type 2 diabetes: A randomized controlled trial
Authors: Hirosaki Mayumi , Ohira Tetsuya , Wu Yawei , Eguchi Eri , Shirai Kokoro , Imano Hironori , Funakubo Narumi , Nishizawa Hitoshi , Katakami Naoto , Shimomura Iichiro , Iso Hiroyasu 
Published: March 2023

BackgroundLaughter has been reported to have various health benefits. However, data on the long-term effects of laughter interventions on diabetes are limited. This study aimed to investigate whether laughter yoga can improve glycemic control among individuals with type 2 diabetes.MethodsIn a single-center, randomized controlled trial, 42 participants with type 2 diabetes were randomly assigned to either the intervention or the control group. The intervention consisted of a 12-week laughter yoga program. Hemoglobin A1c (HbA1c), body weight, waist circumference, psychological factors, and sleep duration were evaluated at baseline and week 12.ResultsIntention-to-treat analysis showed that participants in the laughter yoga group experienced significant improvements in HbA1c levels (between-group difference: −0.31%; 95% CI −0.54, −0.09) and positive affect scores (between-group difference: 0.62 points; 95% CI 0.003, 1.23). Sleep duration tended to increase in the laughter yoga group with a between-group difference of 0.4 hours (95% CI −0.05, 0.86; P = 0.080). The mean attendance rate for laughter yoga program was high (92.9%).ConclusionsA 12-week laughter yoga program is feasible for individuals with type 2 diabetes and improves glycemic control. These findings suggest that having fun could be a self-care intervention. Further studies with larger numbers of participants are warranted to better evaluate the effects of laughter yoga.Clinical trial registrationhttp://www.chinadrugtrials.org.cn, identifier UMIN000047164.
Thirty synchronous medullary and papillary thyroid carcinomas
Authors: Zhang Daqi , Yang Mingyu , Zhang Xin , Wang Cheng , Li Kunlin , Wang Hongbo , Chi Hao , Sui Chengqiu , Dionigi Gianlorenzo , Sun Hui 
Published: March 2023

Synopsis for table of contentsAn exceptional number of synchronous MTC/PTC in the same thyroid gland is presented. This may be the most numerous case series reported in the literature. Synchronous PTC/MTC in the same thyroid gland were classified into 4 subtypes and the clinical and pathological aspects as well as the results are presented.Background and objectivesThe synchronous occurrence of multiple neoplastic processes in the thyroid gland is unusual. We investigated the clinicopathological features of 30 medullary thyroid carcinomas (MTC) in association with papillary (PTC).MethodRetrospective analysis of operated patients for thyroid tumors. Synchronous PTC/MTC in the same thyroid gland were classified into 4 subtypes: (type I) True mixed MTC/PTC, MTC and PTC closely intermingled. (Type II) Collision MTC/PTC, i.e. tumors that meet at the same site, invade each other and appear as a single mass in the thyroid gland, i.e. MTC and PTC merge. (Type III) Synchronous anatomically separate tumors in the same thyroid lobe, i.e. separated from each other by non-tumorous thyroid parenchyma. (Type IV) Synchronous tumors occurring in separate anatomical lobes or in the isthmus. Clinical and pathological data were reviewed. Location: Department of thyroid surgery, China-Japan Union Hospital, Jilin University. Time frame: 14 years (June 2008-November 2022).ResultsThirty patients were identified with an overall prevalence of 28621 (0.1%). 17 (56.7%) were male, 13 (43.3%) female, mean age 51.3 ± 11.0 years, mean BMI 23.6 ± 3.6kg/m2. Mean duration of symptoms was 11.2 ± 18.4 months. Mean calcitonin level was 133.7 ± 196.4 pg/ml. Fine needle aspiration (FNA) was offered in 21 cases: 9 (42.9%) were suspected carcinoma, 9 (42.9%) PTC, 1 (4.8%) MTC, 2 (9.4%) MTC/PTC. Pathology revealed type I 4 (13.3%), type II 2 (6.7%), type III 14 (46.7%), type IV 10 (33.3%). The mean diameter of MTC was 1.6 ± 2.0cm, 18 (60%) were micro-MTC. The mean diameter of PTC was 0.9 ± 1.9 cm, 26 (86.7%) were micro-PTC. In 16 (53.3%) micro-PTC/-MTC occurred in synchronous sequence. Four patients had a recurrence: 2 had to be re-operated due to MTC recurrence, 2 died due to distant metastases (bone, liver).ConclusionWe report an exceptional number of MTC/PTC in the same thyroid gland. This may be the most numerous case series reported in the literature. The clinical and pathological aspects as well as the results are presented.
Electrohydrodynamic air amplifier for low-energy airflow generation—An experimental proof-of-concept
Authors: Rubinetti Donato , Iranshahi Kamran , Onwude Daniel , Nicolaï Bart , Xie Lei , Defraeye Thijs 
Published: March 2023

With electrohydrodynamics (EHD), we can propel air in a low-energy fashion. EHD airflow, or ionic wind, arises when a high voltage gradient is applied to a set of electrodes. The air ionizes between electrodes via corona discharge and accelerates in an electric field, exchanging momentum with the surrounding air. While the ionization process is energy-efficient, reaching competitive flow rates remains challenging from a high-voltage engineering perspective. To increase EHD-generated flow rates, this study experimentally investigates a novel concept called EHD air amplification. The concept uses ionic wind as bleed flow to induce a more significant bulk flow by the air-amplifying Coanda effect. Due to the complex interactions between EHD and dielectric structures for air amplification, the conceptual EHD air amplifier device is designed stage-wise, starting with a simple emitter-collector electrode configuration. First, regular EHD flow was studied in a 150 × 150 × 500 mm3 channel. Then, a dielectric material was added to determine its influence on the electric field. The impact of a converging nozzle on the EHD-generated airflow was subsequently studied. Lastly, the converged nozzle airflow was used to create a bleed flow on a plate to facilitate air amplification of the surrounding air. We show the proof-of-concept for an EHD air amplification system. After a voltage threshold of 14 kV, amplified airstreams up to an amplification factor of 3 were measured. Maximum airflow rates of about 15 m3 h−1 were obtained shortly before electric breakdown at 22 kV. Compared to regular EHD, we achieved a higher aerodynamic performance for the same electric energy invested. The flow rate to electric power ratio increased to 66% in EHD air amplification compared to regular EHD. The proposed EHD air amplifier operates at atmospheric pressure. It lays the groundwork for further optimization studies to position EHD air amplification as a low-energy, low-maintenance, motor- and noiseless airflow generation technology.
Development and demonstration of concentric-type HTS power cable for distribution grid in Shenzhen urban
Authors: Tang Shouquan , Li Minhong , Xie Hong , Wang Zhenzi , Yu Peng , Li Zhonghang , Wang Zhe , Chen Tengbiao , Wang Bangzhu 
Published: March 2023

High-temperature superconducting (HTS) cable can transmit massive power with little dissipation in a limited corridor, which is an attractive solution for future power transmission. Shenzhen Power Supply energized a 400 m/10 kV/2.5 kA concentric HTS cable system on 28 September 2021 to power Ping’an Financial Centre, a Shenzhen’s landmark building, which was the debut of concentric HTS cable made of YBCO in the urban area of a megacity. For more than 1 year, the HTS cable system has been operating well and will continue to operate for a long time. This paper systematically reviews the system specification, cable and its accessories design, cryogenic cooling system design, type and exploratory test, project construction, pre-commissioning test, and operation of the demonstration cable system. Based on our R&amp;D practice, we identify that cost, long-term reliability, and operational simplicity are the main hinders factors that need to be addressed to advance the large-scale application and we propose a set of solution ideas meanwhile.