bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rethinking recovery in adolescent concussions: Network‐level functional connectivity alterations associated with motor deficits
Authors: Crasta Jewel E. , Nebel Mary Beth , Svingos Adrian , Tucker Robert N. , Chen Hsuan Wei , Busch Tyler , Caffo Brian S. , Stephens Jaclyn , Suskauer Stacy J. 
Published: March 2023

AbstractAdolescents who are clinically recovered from concussion continue to show subtle motor impairment on neurophysiological and behavioral measures. However, there is limited information on brain–behavior relationships of persistent motor impairment following clinical recovery from concussion. We examined the relationship between subtle motor performance and functional connectivity of the brain in adolescents with a history of concussion, status post‐symptom resolution, and subjective return to baseline. Participants included 27 adolescents who were clinically recovered from concussion and 29 never‐concussed, typically developing controls (10–17 years); all participants were examined using the Physical and Neurologic Examination of Subtle Signs (PANESS). Functional connectivity between the default mode network (DMN) or dorsal attention network (DAN) and regions of interest within the motor network was assessed using resting‐state functional magnetic resonance imaging (rsfMRI). Compared to controls, adolescents clinically recovered from concussion showed greater subtle motor deficits as evaluated by the PANESS and increased connectivity between the DMN and left lateral premotor cortex. DMN to left lateral premotor cortex connectivity was significantly correlated with the total PANESS score, with more atypical connectivity associated with more motor abnormalities. This suggests that altered functional connectivity of the brain may underlie subtle motor deficits in adolescents who have clinically recovered from concussion. More investigation is required to understand the persistence and longer‐term clinical relevance of altered functional connectivity and associated subtle motor deficits to inform whether functional connectivity may serve as an important biomarker related to longer‐term outcomes after clinical recovery from concussion.
Body mass index and body shape before treatment and nasopharyngeal carcinoma prognosis: A population‐based patient cohort study in southern China
Authors: Du Yun , Feng Ruimei , Chang Ellen T. , Yin Li , Huang Tingting , Li Yancheng , Zhou Xiang , Huang Yi , Zhou Feng , Su Canqiong , Xiao Xue , Jia Weihua , Zheng Yuming , Adami Hans‐Olov , Zeng Yixin , Cai Yonglin , Zhang Zhe , Xu Miao , Ye Weimin 
Published: March 2023

AbstractA concern of reverse causation exists about the association between nasopharyngeal carcinoma (NPC) prognosis and body mass index (BMI) at diagnosis, while the prognostic impact of BMI measured years before diagnosis is unknown. Therefore, we investigated associations of prediagnosis and pretreatment BMI and body shape on NPC mortality. From a population‐based patient cohort in southern China between 2010 and 2013, we included 2526 incident NPC cases with prospective follow‐up through 2018. We assessed the associations of BMI and body shape at age 20 years, 10 years before diagnosis, and at diagnosis with NPC mortality, combining strategies of stratification and statistical adjustment to minimize reverse causation. We observed 25% lower all‐cause mortality (hazard ratio [HR] 0.75, 95% confidence interval [CI]: 0.64‐0.89) and 25% lower NPC‐specific mortality (HR 0.75, 95% CI: 0.61‐0.91) among overweight vs normal‐weight NPC cases at diagnosis. Lean body shapes 1 and 2 at diagnosis were associated with 68% and 23% higher all‐cause mortality, respectively, compared to normal body shape 3. No effect modification by cancer stage was detected for associations with all‐cause or NPC‐specific mortality. Associations with BMI and body shape 10 years before diagnosis were similar but attenuated, while body size and shape at age 20 were not associated with mortality. Being overweight at diagnosis decreased mortality, and thinner body shape increased mortality, compared to normal weight/body shape. These associations may be due to poorer nutrition and treatment intolerance, resulting in treatment discontinuation and worse survival outcomes.
Mechanical and thermomechanical properties of an LLM‐105 based PBX high explosive with and without accelerated aging
Authors: Mirkarimi P. B. , Pease S. T. , Moua Y. , Gagliardi F. J. , Gash A. E. 
Published: March 2023

AbstractIn this paper we present measurements and analysis on the mechanical and thermomechanical properties of the LLM‐105 based plastic bonded high explosive RX‐55‐DQ. Specifically we present uni‐axial compression, and thermal measurements (CTE and ratchet growth), and for some of the measurements we provide a comparison to measurements on TATB‐based PBX 9502. We also present the same mechanical property measurements performed on RX‐55‐DQ samples that underwent accelerated aging.
Early Predicting the Need for Aftercare Based on Patients Events from the First Hours of Stay – A Case Study
Authors: Dubbeldam Annika L. , Ketykó István , de Carvalho Renata M. , Mannhardt Felix 
Published: March 2023

AbstractPatients, when in a hospital, will go through a personalized treatment scheduled for many different reasons and with various outcomes. Furthermore, some patients and/or treatments require aftercare. Identifying the need for aftercare is crucial for improving the process of the patient and hospital. A late identification results in a patient staying longer than needed, occupying a bed that otherwise could serve another patient. In this paper, we will investigate to what extent events from the first hours of stay can help in predicting the need for aftercare. For that, we explored a dataset from a Dutch hospital. We compared different methods, considering different prediction moments (depending of the amount of initial hours of stay), and we evaluate the gain in earlier predicting the need for aftercare.
Detecting Complex Anomalous Behaviors in Business Processes: A Multi-perspective Conformance Checking Approach
Authors: Mozafari Mehr Azadeh Sadat , M. de Carvalho Renata , van Dongen Boudewijn 
Published: March 2023

AbstractIn recent years, organizations are putting an increasing emphasis on anomaly detection. Anomalies in business processes can be an indicator of system faults, inefficiencies, or even fraudulent activities. In this paper we introduce an approach for anomaly detection. Our approach considers different perspectives of a business process such as control flow, data and privacy aspects simultaneously.Therefore, it is able to detect complex anomalies in business processes like spurious data processing and misusage of authorizations. The approach has been implemented in the open source ProM framework and its applicability was evaluated through a real-life dataset from a financial organization. The experiment implies that in addition to detecting anomalies of each aspect, our approach can detect more complex anomalies which relate to multiple perspectives of a business process.
Leveraging Event Data for Measuring Process Complexity
Authors: Vidgof Maxim , Mendling Jan 
Published: March 2023

AbstractComplexity is an important aspect of business processes. Numerous metrics have been introduced to measure process complexity, however, existing metrics view processes merely as sequences of activities, disregarding the corresponding data. This is a major omission since much of the complexity of business processes stems from the variation of data that is associated with it. In this paper, we refer to recent research on how behavioral complexity of business processes can be defined. More specifically, we extend entropy-based complexity metrics such that they are capable of capturing the variation of event data. We provide some first insights into the implications of applying these newly proposed metrics.
BacSp222 bacteriocin as a novel ligand for TLR2/TLR6 heterodimer
Authors: Śmiałek-Bartyzel Justyna , Bzowska Monika , Mężyk-Kopeć Renata , Kwissa Marcin , Mak Paweł 
Published: March 2023

Abstract
Objective and design
BacSp222 bacteriocin is a bactericidal and proinflammatory peptide stimulating immune cells to produce selected cytokines and NO in NF-ĸB dependent manner. This study aims to identify the receptor which mediates this activity.

Methods
We applied fluorescently labeled BacSp222 and a confocal microscopy imaging to analyze the direct interaction of the bacteriocin with the cells. Reporter HEK-Blue cells overexpressing human toll-like receptors (TLR2, TLR4, TLR5 or TLR2/TLR1 and TLR2/TLR6 heterodimers) were stimulated with BacSp222, and then the activity of NF-ĸB-dependent secreted embryonic alkaline phosphatase (SEAP) was measured. In turn, formylated peptide receptor (FPR) or TLR2 antagonists were used to verify bacteriocin-stimulated TNF production by murine monocyte-macrophage cell lines.

Results
BacSp222 undergoes internalization into cells without disturbing the cell membrane. FPR antagonists do not affect TNF produced by BacSp222-stimulated murine macrophage-like cells. In contrast, BacSp222 stimulates NF-ĸB activation in HEK-Blue overexpressing TLR2 or TLR2/TLR6 heterodimer, but not TLR2/TLR1, TLR4 or TLR5 receptors. Moreover, TLR2-specific antagonists inhibit NF-ĸB signaling in BacSp222-stimulated HEK-Blue TLR2/TLR6 cells and reduce TNF release by BacSp222-treated RAW 264.7 and P388.D1.

Conclusions
BacSp222 is a novel ligand for TLR2/TLR6 heterodimer. By binding TLR complex the bacteriocin undergoes internalization, inducing proinflammatory signaling that employs MyD88 and NF-ĸB pathways.
Improved exosome isolation methods from non-small lung cancer cells (NC1975) and their characterization using morphological and surface protein biomarker methods
Authors: Mahgoub Elham O. , Abdella Galal M. 
Published: March 2023

AbstractThis study has demonstrated improved methods for isolating exosomes from non-small lung cancer cells, which address the problems characterized by exosome morphological and chemical methods. To improve the isolation methods, cells from the NCI 1975 cell line were used as the source for exosomes. The isolation processes were carried out using serial isolation techniques in addition to specific preservation tools. The isolated exosomes were characterized using transmission electron microscopy (TEM), and scanning electron microscopy (SEM) was added for further assurance of the investigation results. The statistical analysis results showed that the size distributions of apoptotic vesicles (APV) 450 nm and necrotic bodies (NCB) 280 nm (extracellular vesicles) were significantly different from exosomes (P < 0.001). In contrast, the exosome size distribution was not significantly different from the published exosome sizes, as demonstrated by statistical analysis tools. This study confirmed the improved methods for isolating exosomes that make exosomes accessible for use in the diagnosis and prognosis of non-small cell lung cancer (NSCLC).
A comparative analysis of continuum plasticity, viscoplasticity and phase-field models for earthquake sequence modeling
Authors: Goudarzi M. , Gerya T. , Dinther Y. van 
Published: March 2023

AbstractThis paper discusses continuum models for simulating earthquake sequences on faults governed by rate-and-state dependent friction. Through detailed numerical analysis of a conventional strike-slip fault, new observations regarding the use of various continuum earthquake models are presented. We update a recently proposed plasticity-based model using a consistently linearized formulation, show its agreement with discrete fault models for fault thicknesses of hundreds of meters, and demonstrate mesh objectivity for slip-related variables. To obtain a fully regularized fault width description with an internal length scale, we study the performance and mesh convergence of a plasticity-based model complemented by a Kelvin viscosity term and the phase-field approach to cohesive fracture. The Kelvin viscoplasticity-based model can introduce an internal length scale and a mesh-objective response. However, on grid sizes down to meters, this only holds for very high Kelvin viscosities that inhibit seismic slip rates, which renders this approach impractical for simulating earthquake sequences. On the other hand, our phase-field implementation for earthquake sequences provides a numerically robust framework that agrees with a discrete reference solution, is mesh objective, and reaches seismic slip rates. The model, unsurprisingly, requires highly refined grids around the fault zones to reproduce results close to a discrete model. Following this line, the effect of an internal length scale parameter on the phase-field predictions and mesh convergence are discussed.
Matching centroids by a projective transformation
Authors: Izmestiev Ivan 
Published: March 2023

AbstractGiven two subsets of$$\mathbb {R}^d$$Rd, when does there exist a projective transformation that maps them to two sets with a common centroid? When is this transformation unique modulo affine transformations? We study these questions for 0- andd-dimensional sets, obtaining several existence and uniqueness results as well as examples of non-existence or non-uniqueness. If both sets have dimension 0, then the problem is related to the analytic center of a polytope and to polarity with respect to an algebraic set. If one set is a single point, and the other is a convex body, then it is equivalent by polar duality to the existence and uniqueness of the Santaló point. For a finite point set versus a ball, it generalizes the Möbius centering of edge-circumscribed convex polytopes and is related to the conformal barycenter of Douady-Earle. If both sets ared-dimensional, then we are led to define the Santaló point of a pair of convex bodies. We prove that the Santaló point of a pair exists and is unique, if one of the bodies is contained within the other and has Hilbert diameter less than a dimension-depending constant. The bound is sharp and is obtained by a box inside a cross-polytope.
Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts
Authors: Pennarossa Georgia , Arcuri Sharon , De Iorio Teresina , Ledda Sergio , Gandolfi Fulvio , Brevini Tiziana A. L. 
Published: March 2023

Abstract
Purpose
This study is to develop a new protocol that combines the use of epigenetic cues and mechanical stimuli to assemble 3D spherical structures, arbitrarily defined “epiBlastoids,” whose phenotype is remarkably similar to natural embryos.

Methods
A 3-step approach is used to generate epiBlastoids. In the first step, adult dermal fibroblasts are converted into trophoblast (TR)-like cells, combining the use of 5-azacytidine, to erase the original phenotype, with an ad hoc induction protocol, to drive cells towards TR lineage. In the second step, epigenetic erasing is applied once again, in combination with mechanosensing-related cues, to generate inner cell mass (ICM)-like organoids. Specifically, erased cells are encapsulated into micro-bioreactors to promote 3D cell rearrangement and boost pluripotency. In the third step, TR-like cells are co-cultured with ICM-like spheroids in the same micro-bioreactors. Subsequently, the newly generated embryoids are transferred to microwells to favor epiBlastoid formation.

Results
Adult dermal fibroblasts are successfully readdressed towards TR lineage. Cells subjected to epigenetic erasing and encapsulated into micro-bioreactors rearrange in 3D ICM-like structures. Co-culture of TR-like cells and ICM-like spheroids into micro-bioreactors and microwells induces the formation of single structures with uniform shape reminiscent in vivo embryos. CDX2+ cells localized in the out layer of the spheroids, while OCT4+ cells in the inner of the structures. TROP2+ cells display YAP nuclear accumulation and actively transcribed for mature TR markers, while TROP2− cells showed YAP cytoplasmic compartmentalization and expressed pluripotency-related genes.

Conclusion
We describe the generation of epiBlastoids that may find useful application in the assisted reproduction field.
The income gap reporting framework in public not-for-profit organizations: the British Museum case
Authors: Ferri Paolo , Napolitano Simone , Zan Luca 
Published: March 2023

AbstractThe income gap is the negative margin between earned income and operating expenses: this is the main financial concern for not-for-profit entities (both public sector and nongovernmental organizations). Despite this, all over the world these entities are forced to use the standard profit-centered income statements format, with its focus on net income generation (the bottom line). This paper proposes an income statement format that uses the income gap to understand/discuss/present the financial viability of a not-for-profit entity in the arts sector, specifically a museum. We apply the framework to the British Museum’s income statements from 1999–2000 to 2018–2019. This allows us to analyze institutional narratives in the context of the evolution of the museum’s financial viability over two decades, and to assess the performance of the museum’s neoliberal reform agenda from the end of the 1990s. Enlarging the perspective, ad hoc adaptations of the framework can allow a better understanding of the financial viability of not-for-profit organizations, in the arts sector and possibly more broadly in public services and not-for-profit sector.
Decomposability of multiparameter car flows
Authors: Arjunan Anbu 
Published: March 2023

AbstractLet P be a closed convex cone in $\mathbb{R}^d$ which is assumed to be spanning $\mathbb{R}^d$ and contains no line. In this article, we consider a family of CAR flows over P and study the decomposability of the associated product systems. We establish a necessary and sufficient condition for CAR flow to be decomposable. As a consequence, we show that there are uncountable many CAR flows which are cocycle conjugate to the corresponding CCR flows.
Effects of Snow Cover on Spring Vegetation Phenology Vary With Temperature Gradient Across the Pan‐Arctic
Authors: Wu Youlv , Xiao Pengfeng , Zhang Xueliang , Liu Hao , Dong Yuanbiao , Feng Lian 
Published: March 2023

AbstractExtensive and complex changes in spring vegetation phenology have occurred in the Pan‐Arctic over the last several decades. However, the role of snow cover at the start of the growing season (SOS) under different climatic conditions remains unclear. Therefore, we compare the effects of four snow indicators on SOS from 1982 to 2015 based on long‐term remote sensing data and found that snow cover end date (SCED) is the main snow indicator affecting SOS, with SOS advancing 0.56 days for each 1‐day advance in SCED, explaining 12%–90% of SOS variability in 63% of the Pan‐Arctic region. The results also demonstrate that SCED is the dominant factor on SOS in 13% of the Pan‐Arctic region and the effects of SCED on SOS vary with temperature gradient rather than precipitation gradient. In cold areas, the positive effect of SCED on SOS diminished with increasing temperature, while in warm areas, the positive effect of SCED on SOS increased with increasing temperature. As the climate warms, the impact of SCED on SOS is expected to weaken in cold areas and increase in warm areas. The findings have crucial implications for understanding future vegetation phenological responses to climate change across the Pan‐Arctic.
Detection of fault zone head waves and the fault interface imaging in the Xianshuihe–Anninghe Fault zone (Eastern Tibetan Plateau)
Authors: Wang Longtan , Zhou Yijian , Zhou Shiyong , Zhang Hao 
Published: March 2023

SUMMARYFault zone head waves (FZHWs) are an essential diagnostic signal that provides high-resolution imaging of fault interface properties at seismogenic depth. In this study, we validate the existence of a bi-material interface in the Xianshuihe–Anninghe Fault (XAF) zone around their intersection and determine the cross-fault velocity contrast. We employ a semi-automatic workflow to detect and pick FZHWs and direct P waves. In addition, to improve the identification ability of potential FZHWs in the automatic picking process, we adopt a ‘forward-detecting and backward-picking’ strategy combining the short-term average/long-term average (STA/LTA) algorithm with a kurtosis detector. The polarization and characteristic periods of the waveforms are then used to manually refine the picks and evaluate the quality. The results indicate that the average velocity contrast along the southern Xianshuihe Fault is 3–5 per cent, with the northeast side characterizing a faster P-wave velocity, in agreement with tomographic results. A systematic moveout between FZHWs and the direct P waves over a 100 km long fault segment reveals a single continuous interface in the seismogenic zone. The single bi-material fault structure might be conducive to the preparation of large earthquakes and further influences the corresponding dynamic rupture processes.
Tilting and Silting Theory of Noetherian Algebras
Authors: Kimura Yuta 
Published: March 2023

Abstract
We develop silting theory of a Noetherian algebra $\Lambda $ over a commutative Noetherian ring $R$. We study mutation theory of $2$-term silting complexes of $\Lambda $, and as a consequence, we see that mutation exists. As in the case of finite-dimensional algebras, functorially finite torsion classes of $\Lambda $ bijectively correspond to silting $\Lambda $-modules, if $R$ is complete local. We show a reduction theorem of $2$-term silting complexes of $\Lambda $, and by using this theorem, we study torsion classes of the module category of $\Lambda $. When $R$ has Krull dimension one, we describe the set of torsion classes of $\Lambda $ explicitly by using the set of torsion classes of finite-dimensional algebras.