bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usable STEM knowledge for tomorrow's STEM problems
Authors: Butler Songer Nancy 
Published: January 2023

Usable STEM knowledge for tomorrow's STEM problems
More universities and education programs need more STEM knowledge in formal and informal settings to guide learners in applying STEM learning to the creation of solutions. To address this challenge, Nancy Butler Songer, the dean of the College of Education at the University of Utah designed a learning approach, Solutioning, that guides youth to deepen science content through science and engineering practices. Creating a six-week curricular program, the learning approach provided opportunities for students to use engineering design to create and provide feedback on a trap design that would attract a local invasive insect that was harmful to their community. Research was conducted on studies to provide empirical evidence on student STEM knowledge and learning and their ability to define science and engineering. Research results indicate that even elementary-age students demonstrate significant improvement in their understanding of STEM arguments as evaluated with a pre-post assessment before and after implementing a six-week solutioning curricular program.
Calorimetric studies and safety tests on lithion-ion cells and post-lithium cells
Authors: Ziebert Carlos , Barbu Corneliu , Jezdinsky Tomas 
Published: January 2023

Calorimetric studies and safety tests on lithion-ion cells and post-lithium cells
Open Access Government interviews Dr Carlos Ziebert, of the Karlsruhe Institute of Technology (KIT), who explores the thermal and safety properties of batteries across calorimetric studies. The group batteries – calorimetry and safety – focus on calorimetric studies and safety tests on lithium-ion cells and post-lithium cells. Depending on the cell size and application, different types of calorimeters are used in Europe's largest Battery Calorimeter Laboratory, established in 2011. It provides seven Accelerating Rate Calorimeters (ARCs) from Thermal Hazard Technology allowing the evaluation of thermodynamic, thermal and safety data for Lithium-ion and post-Li cells on material, cell, and pack levels for both normal and abuse conditions (thermal, electrical, mechanical). The lab also includes glove boxes for cell assembly and disassembly, many temperature chambers, a thermal camera, and cyclers with several hundred channels. It contains extremely sensitive 3D Calvet calorimeters, providing thermodynamic parameters and gas chromatography-mass spectrometry systems from Perkin-Elmer for venting gas analysis.
A new approach to older people's end of life care: Living and dying well
Authors: Nicholson Caroline 
Published: January 2023

A new approach to older people's end of life care: Living and dying well
Global ageing means that death is now most commonly an event of older age. For most older people, the nature of living and dying in later life will be frailty and multimorbidity (MM - the co-existence of two or more long-term conditions). Remodelling palliative and end of life care requires different ways of working, different partnerships and a sharing of power.
Role of Metaphors in Controlling Meaning Making Processes: ‘War’ and ‘Fire’ Metaphor for COVID-19 Pandemic
Authors: Rafat Misbah 
Published: January 2023

Purpose: In recent times, development of languages has endorsed complexities and has advanced the communicative strategies. This present research has studied the role of ‘war’ and ‘fire’ metaphors for COVID-19 pandemic in influencing thinking pattern of people to analyze the differences in the meaning attached to the concepts of metaphors.
Methodology: Open ended questionnaires were designed in qualitative research method and responses were encoded to generate the emerging patterns of meanings.
Findings: The results have shown the contrasting features of the meaning making sense of people in accordance with the metaphors and it further gave way to analyze the conscious impact of usage of metaphors by higher authorities in molding public’s thought according to their own interest. Fire metaphor has enraged the feeling of suffocation and fast rate of transmission of this pandemic while ‘war’ metaphor has raised the meaning of killing of people and people has assumed this pandemic as an enemy which has turned this world into a battlefield.
Conclusion: Figurative and non-figurative languages elicited different responses. Non-figurative language did not instigated any kind of fear among the participants.
Recommendation: Future studies can be conducted to scrutinize the ideological use of metaphors by the politicians which insinuate audience in one way or another.
PERIODICAL MAINTENANCE SERVICE VOLVO TRUCK FMX 440 DI PT. MADHANI TALATAH NUSANTARA
Authors: Darsini Darsini 
Published: January 2023

Periodical Service adalah pemeliharaan mesin agar dapat mengurangi frekuensi kerusakan dan lamanya waktu kerusakan. Dengan pelaksanaan perawatan yang baik dan efisien, dapat mempertahankan waktu operasi suatu alat, menjaga alat tetap produksi, mengurangi biaya kerusakan yang tidak diharapkan. Tujuannya adalah untuk : (1) Pelaksanaan kegiatan Periodical Service pada saat kegiatan tersebut, (2) mengetahui kapan dilakukannya Periodical Service yang terdiri dari PS 250, PS 500, PS 1000 dan PS 2000, (3) Mengetahui hasil dari Periodical Service. Pelaksanaan Periodical Service yang dilaksanakan di PT. Madhani, khususnya pada truck volvo meliputi pergantian oli engine, mengganti filter oli engine, mengganti oli transmisi dan filternya, mengganti oli final drive sampai pengecheckan battrey dan elektrikal. Dengan program Periodical Service data menunjukkan hasil PA (Physical Avelaibelity) lebih dari 95%, MTBF (Mean Time Between Failures) lebih dari 3000 jam, dan MTTR (Mean Time To Repair) kurang dari 20 jam, maka program ini sangat efektif dan efisien untuk meningkatkan produksi.
New nematode species and genera (Nematoda: Chromadorea) from cold seeps on Hikurangi Margin, New Zealand
Authors: Leduc Daniel 
Published: January 2023

Relatively little is known about the taxonomy and ecology of deep-sea nematode species inhabiting cold seep habitats. The available data show that cold seep nematode communities are typically characterized by low diversity and are often dominated by a single species, although no nematode taxon appears to have a strong association with methane seepage. In July 2019, a research voyage to New Zealand’s Hikurangi Margin provided an opportunity to characterize the nematode species communities of New Zealand cold seeps, which had not been investigated until now. Here, six new species and two new nematode genera of the class Chromadorea are described from macrofauna cores obtained at three seep sites (Mungaroa, Glendhu, and Uruti South) on Hikurangi Margin from 1227 to 2077 m depth. The species described here represent a wide range of feeding groups, ranging from deposit feeders (Linhomoeus pycnocricus sp. nov., Deraionema barbatum gen. et sp. nov.) to microvores (Aulostomonema abyssum gen. et sp. nov., Aegialoalaimus magnus sp. nov.) and epigrowth feeders (Desmodora parapilosa sp. nov.). The diet of Siphonolaimus curtisensillus sp. nov., which is characterized by an unusual stylet-like feeding apparatus, remains to be determined, however the presence of several different feeding modes in the species described here indicates that a range of food sources are exploited by macrofaunal nematodes at the study sites. Desmodora, Linhomoeus, and Aegialoalaimus have been reported from cold seep habitats previously, however no records of Siphonolaimus from cold seeps could be found in the literature. Aulostomonema gen. nov. does not appear to have a close association with seeps, whilst Deraionema gen. nov. appears to be restricted to the centre of the seep sites where methane seepage is likely strongest. Ongoing work on the ecology and distribution of nematode communities at the Hikurangi Margin seep sites will help determine spatial patterns in abundance and species distributions in more detail, including the identification of any species/taxa with affinities with methane seepage.
Tres sellos para un infante: documentos de Don Felipe, abad de Valladolid y arzobispo electo de Sevilla (1229/31-1278)
Authors: BELMONTE FERNÁNDEZ Diego 
Published: January 2023

This work aims to study and value the few original documents, and the seals that they carry and that have come down to us, issued by a character who has gone through something unnoticed in the history of the Church of Seville, the infante Don Felipe, son of Fernando III and brother of Alfonso X, the Wise. Despite such notable kingship, the figure of the person who was appointed to occupy the Seville archiepiscopal seat in the first place after the conquest of the city by Christian power, has always been overshadowed for various reasons. However, the few documents located present an interesting triple representation of the infant according to the different moments of his life curriculum. Although these pieces have been used as historical sources, they have never been studied by themselves.
El objetivo del presente trabajo es estudiar y poner en valor los escasos documentos originales, y los sellos que portan y que han llegado hasta nosotros, emitidos por un personaje que ha pasado algo desapercibido en la historia de la Iglesia de Sevilla, el infante don Felipe, hijo de Fernando III y hermano de Alfonso X, el Sabio. A pesar de tan notable parentela, la figura del que fuera designado para ocupar la sede arzobispal hispalense en primer lugar tras la conquista de la ciudad por el poder cristiano ha estado siempre ensombrecida por varias razones. Sin embargo, los pocos documentos localizados presentan una interesantísima triple representación del infante acorde con los distintos momentos de su currículo vital. Estas piezas, si bien han sido utilizadas como fuentes históricas, no han sido nunca estudiadas por sí mismas.
Reconsiderando el “consecuencialismo kantiano”
Authors: Oliveira Martin 
Published: January 2023

En este trabajo hemos tratado de evaluar el consecuencialismo kantiano que defiende David Cummiskey. La inspiración kantiana de esta particular lectura es innegable. Parte de una teoría del valor moral muy semejante a la del filósofo de Könisberg, trata muchas de las cuestiones textuales de las principales obras kantianas pero llega a conclusiones radicalmente distintas. En esto último radica el principal atractivo de una interpretación consecuencialista de Kant. Mientras que uno podría sugerir que la tradición leyó incorrectamente a Kant y que la perspectiva de Cummiskey es la mejor reconstrucción del pensamiento de este filósofo, hay elementos para poner esto en duda.
UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion
Authors: Tang Yunfeng , Sun Lixin , Zhao Yun , Yao Jingchun , Feng Zhong , Liu Zhong , Zhang Guimin , Sun Chenghong 
Published: January 2023

Background
Icaritin (ICT) has been previously demonstrated to display protective effects against cerebral ischemic reperfusion (I/R) by inhibiting oxidative stress, but the mechanism remains unclear. This study aimed to explore the mechanism from the perspective of metabolomics.

Methods
A mice cerebral artery occlusion/reperfusion (MCAO/R) model was explored to mimic cerebral ischemic reperfusion and protective effect of ICT was assessed by neurologic deficit scoring, infarct volume and brain water content. Ultra-high-performance liquid chromatography electrospray ionization orbitrap tandem mass spectrometry (UHPLC-ESI-QE-Orbitrap-MS) based metabolomic was performed to explore potential biomarkers. Brain tissue metabolic profiles were analyzed and metabolic biomarkers were identified through multivariate data analysis. The protein levels of Nrf2, HO-1 and HQO1 were assayed by western blot. The release of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) were detected using corresponding assay kits.

Results
The results showed that after ICT treatment, the neurological deficit, cerebral infarction area, brain edema and the level of MDA in brain tissue of MCAO/R mice were significantly reduced. Meanwhile, ICT enhanced the activity of SOD, CAT and GSH-Px. Western blot results confirmed that ICT up-regulated the protein levels of antioxidant-related protein including Nrf2, HO-1 and NQO1. According to the metabolomic profiling of brain tissues, clear separations were observed among the Sham, Model and ICT groups. A total of 44 biomarkers were identified, and the identified biomarkers were mainly related to linoleic acid metabolism, arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, arginine biosynthesis, arginine and proline metabolism, D-glutamine and D-glutamate metabolism, taurine and hypotaurine metabolism and purine metabolism, respectively. At the same time, the inhibitory effect of ICT on arachidonic acid and linoleic acid in brain tissue, as well as the promoting effect on taurine, GABA, NAAG, may be the key factors for the anti-neurooxidative function of mice after MCAO/R injury.

Conclusion
Our results demonstrate that ICT has benefits for MCAO/R injury, which are partially related to the suppression of oxidative stress via stimulating the Nrf2 signaling and regulating the production of arachidonic acid, linoleic acid, taurine, GABA, NAAG in brain tissue.
Aprendizagem ativa: um novo olhar sobre organizações que aprendem
Authors: Silva Ricardo Freitas da , Pantoja Maria Júlia 
Published: January 2023

Este artigo tem como objetivo analisar a produção científica nacional sobre andragogia, aprendizagem ativa e aprendizagem organizacional, no período de 2015 a 2021, a fim de identificar a contribuição da educação a distância (EAD) no processo de aprendizagem para a superação dos desafios enfrentados pelas organizações na atualidade. Para tanto, realizou-se uma revisão sistemática da literatura baseada no protocolo de seleção e análise das fontes definido por Cronnin, et al. (2008). A pesquisa qualiquantitativa foi realizada em periódicos com classificação Qualis Capes A1 a B2, na base de dados Web of Science. Utilizou-se mapeamento bibliométrico na análise das publicações e o software Iramuteq para o processamento dos dados lexicais dos resumos dos artigos selecionados. Os resultados advindos da pesquisa apontam para a educação a distância como modelo potencial para o processo educativo capaz de trabalhar diferentes competências organizacionais.
Epilithic Diatoms in the River Spreča Affected by Urban and Industrial Pollution, Bosnia and Herzegovina
Authors: Selimović Samela , Huseinović Samira , Kamberović Jasmina , Bektić Sanida , Đozić Abdel 
Published: January 2023

Benthic diatoms have gained prominence as environmental bioindicators since the beginning of the twentieth century. Epilithic diatom taxa are frequently used for ecological water-quality assessments of rivers. Diversity of these dominant group of protists in the benthic communities can be indicative of changes in the freshwater ecosystem. The aim of this study was to analyze the diversity and ecology of diatoms of the Spreča River on the locations affected by urban and industrial pollution. Field sampling of the epilithic diatoms was carried out in the period of May 2021 at two locations, first before and second after the Lukavac city, which is known as industrial city in Bosnia and Herzegovina. Taxonomic verification was carried out using light microscope on permanent slides and revealed in total 38 diatom taxa. The genera with the largest number of species were Diatoma, Navicula and Nitzshia. Identified taxa are widespread species that are known for tolerating high levels of pollution. A slightly higher number of taxa was recorded at the first location, while at the second, a higher proportion of halophilic taxa was observed.
Autism Spectrum Disorder
Authors: Hirota Tomoya , King Bryan H. 
Published: January 2023

ImportanceAutism spectrum disorder (ASD), characterized by deficits in social communication and the presence of restricted, repetitive behaviors or interests, is a neurodevelopmental disorder affecting approximately 2.3% children aged 8 years in the US and approximately 2.2% of adults. This review summarizes evidence on the diagnosis and treatment of ASD.ObservationsThe estimated prevalence of ASD has been increasing in the US, from 1.1% in 2008 to 2.3% in 2018, which is likely associated with changes in diagnostic criteria, improved performance of screening and diagnostic tools, and increased public awareness. No biomarkers specific to the diagnosis of ASD have been identified. Common early signs and symptoms of ASD in a child’s first 2 years of life include no response to name when called, no or limited use of gestures in communication, and lack of imaginative play. The criterion standard for the diagnosis of ASD is a comprehensive evaluation with a multidisciplinary team of clinicians and is based on semistructured direct observation of the child’s behavior and semistructured caregiver interview focused on the individual’s development and behaviors using standardized measures, such as the Autism Diagnostic Observation Schedule-Second Edition and the Autism Diagnostic Interview. These diagnostic measures have sensitivity of 91% and 80% and specificity of 76% and 72%, respectively. Compared with people without ASD, individuals with ASD have higher rates of depression (20% vs 7%), anxiety (11% vs 5%), sleep difficulties (13% vs 5%), and epilepsy (21% with co-occurring intellectual disability vs 0.8%). Intensive behavioral interventions, such as the Early Start Denver Model, are beneficial in children 5 years or younger for improvement in language, play, and social communication (small to medium effect size based on standardized mean difference). Pharmacotherapy is indicated for co-occurring psychiatric conditions, such as emotion dysregulation or attention-deficit/hyperactivity disorder. Risperidone and aripiprazole can improve irritability and aggression (standardized mean difference of 1.1, consistent with a large effect size) compared with placebo. Psychostimulants are effective for attention-deficit/hyperactivity disorder (standardized mean difference of 0.6, consistent with a moderate effect size) compared with placebo. These medications are associated with adverse effects including, most commonly, changes in appetite, weight, and sleep.Conclusions and RelevanceASD affects approximately 2.3% of children aged 8 years and approximately 2.2% of adults in the US. First-line therapy consists of behavioral interventions, while co-occurring psychiatric conditions, such as anxiety or aggression, may be treated with specific behavioral therapy or medication.
Timeliness and Modality of Treatment for New Cancer Diagnoses During the COVID-19 Pandemic in Canada
Authors: Fu Rui , Sutradhar Rinku , Li Qing , Hanna Timothy P. , Chan Kelvin K. W. , Irish Jonathan C. , Coburn Natalie , Hallet Julie , Dare Anna , Singh Simron , Parmar Ambica , Earle Craig C. , Lapointe-Shaw Lauren , Krzyzanowska Monika K. , Finelli Antonio , Louie Alexander V. , Hong Nicole J. Look , Witterick Ian J. , Mahar Alyson , Urbach David R. , McIsaac Daniel I. , Enepekides Danny , Tinmouth Jill , Eskander Antoine 
Published: January 2023

ImportanceThe impact of COVID-19 on the modality and timeliness of first-line cancer treatment is unclear yet critical to the planning of subsequent care.ObjectiveTo explore the association of the COVID-19 pandemic with modalities of and wait times for first cancer treatment.Design, Setting, and ParticipantsThis retrospective population-based cohort study using administrative data was conducted in Ontario, Canada, among adults newly diagnosed with cancer between January 3, 2016, and November 7, 2020. Participants were followed up from date of diagnosis for 1 year, until death, or until June 26, 2021, whichever occurred first, to ensure a minimum of 6-month follow-up time.ExposuresReceiving a cancer diagnosis in the pandemic vs prepandemic period, using March 15, 2020, the date when elective hospital procedures were halted.Main Outcomes and MeasuresThe main outcome was a time-to-event variable describing number of days from date of diagnosis to date of receiving first cancer treatment (surgery, chemotherapy, or radiation) or to being censored. For each treatment modality, a multivariable competing-risk regression model was used to assess the association between time to treatment and COVID-19 period. A secondary continuous outcome was defined for patients who were treated 6 months after diagnosis as the waiting time from date of diagnosis to date of treatment.ResultsAmong 313 499 patients, the mean (SD) age was 66.4 (14.1) years and 153 679 (49.0%) were male patients. Those who were diagnosed during the pandemic were less likely to receive surgery first (subdistribution hazard ratio [sHR], 0.97; 95% CI, 0.95-0.99) but were more likely to receive chemotherapy (sHR, 1.26; 95% CI, 1.23-1.30) or radiotherapy (sHR, 1.16; 95% CI, 1.13-1.20) first. Among patients who received treatment within 6 months from diagnosis (228 755 [73.0%]), their mean (SD) waiting time decreased from 35.1 (37.2) days to 29.5 (33.6) days for surgery, from 43.7 (34.1) days to 38.4 (30.6) days for chemotherapy, and from 55.8 (41.8) days to 49.0 (40.1) days for radiotherapy.Conclusions and RelevanceIn this cohort study, the pandemic was significantly associated with greater use of nonsurgical therapy as initial cancer treatment. Wait times were shorter in the pandemic period for those treated within 6 months of diagnosis. Future work needs to examine how these changes may have affected patient outcomes to inform future pandemic guideline development.
An evaluation of the use of DirectSPR images for proton planning in the RayStation treatment planning software
Authors: Sarkar Vikren , Paxton Adam , Su Fanchi , Price Ryan , Nelson Geoff , Szegedi Martin , James Sara St. , Salter Bill J. 
Published: January 2023

AbstractAn important source of uncertainty in proton therapy treatment planning is the assignment of stopping‐power ratio (SPR) from CT data. A commercial product is now available that creates an SPR map directly from dual‐energy CT (DECT). This paper investigates the use of this new product in proton treatment planning and compares the results to the current method of assigning SPR based on a single‐energy CT (SECT). Two tissue surrogate phantoms were CT scanned using both techniques. The SPRs derived from single‐energy CT and by DirectSPR™ were compared to measured values. SECT‐based values agreed with measurements within 4% except for low density lung and high density bone, which differed by 13% and 8%, respectively. DirectSPR™ values were within 2% of measured values for all tissues studied. Both methods were also applied to scanned containers of three types of animal tissue, and the expected range of protons of two different energies was calculated in the treatment planning system and compared to the range measured using a multi‐layer ion chamber. The average difference between range measurements and calculations based on SPR maps from dual‐ and single‐energy CT, respectively, was 0.1 mm (0.07%) versus 2.2 mm (1.5%). Finally, a phantom was created using a layer of various tissue surrogate plugs on top of a 2D ion chamber array. Dose measurements on this array were compared to predictions using both single‐ and dual‐energy CTs and SPR maps. While standard gamma pass rates for predictions based on DECT‐derived SPR maps were slightly higher than those based on single‐energy CT, the differences were generally modest for this measurement setup. This study showed that SPR maps created by the commercial product from dual‐energy CT can successfully be used in RayStation to generate proton dose distributions and that these predictions agree well with measurements.