bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Academic Medical Centers on Surgical Outcomes of Neighboring Non-Academic Medical Centers
Authors: Khalil Mujtaba , Rashid Zayed , Woldesenbet Selamawit , Altaf Abdullah , Kawashima Jun , Chatzipanagiotou Odysseas P , Tsai Susan , Pawlik Timothy M 
Published: January 2025

Introduction:
We aimed to investigate the geographic variation of Academic Medical Centers (AMCs) across different healthcare markets and the impact on surgical outcomes in nearby non-AMCs.

Methods:
Patients who underwent major surgery between 2016 and 2021 were identified from the Medicare Standard Analytic Files. Healthcare markets were delineated using Dartmouth Atlas hospital referral regions. Multivariable regression was used to examine the association between the presence of market-level AMCs and surgical outcomes in neighboring non-AMCs.

Results:
A total of 388,431 Medicare beneficiaries underwent major surgery (CABG: n=97,346, 25.1%; AAA repair: n=67,000, 17.3%; pneumonectomy: n=30,500, 7.9%; pancreatectomy: n=5,341, 1.4%; colectomy: n=188,244, 48.5%) at 2,757 non-AMCs. Median age was 74 years (IQR: 70–80), and roughly one-half of patients was male (n=215,569, 55.5%). Notably, 43.1% of individuals underwent surgery in markets with low AMC presence, 48.0% in markets with moderate AMC presence, and 8.9% in markets with high AMC presence. On multivariable analysis, compared with low AMC markets, high AMC presence was associated with decreased risk of extended length-of-stay (–1.51%, 95% CI –2.03 to –1.00), postoperative complications (–1.20%, 95% CI –1.76 to –0.65), 90-day readmission (–2.39%, 95% CI –2.90 to –1.88), and mortality (–0.64% 95% CI –0.98 to –0.30) (all p<0.001). Moreover, high AMC market presence was associated with a 2.93% (–2.93%, 95% CI –3.17 to –2.68; p<0.001) decrease in expenditures for the index surgical procedure.

Conclusion:
High market presence of AMCs was associated with lower morbidity and mortality rates at nearby non-AMCs. The influence of AMCs on clinical outcomes likely extends beyond direct patient care, indicating spillover effects of AMCs on outcomes for patients in neighboring non-AMCs.
Leveraging Artificial Intelligence as a Safety Net for Incidentally Identified Lung Nodules at a Tertiary Center
Authors: Woodhouse Palina , Paez Rafael , Meyers Patrick , Lentz Rob J , Shoajaee Samira , Sharp Kenneth , Baldi Nikki , Maldonado Fabien , Grogan Eric L 
Published: January 2025

Background:
Artificial intelligence (AI)-powered platforms may be used to ensure that clinically significant lung nodules receive appropriate management. We studied the impact of a commercially available AI natural language processing tool on detection of clinically significant indeterminate pulmonary nodules (IPNs) based on radiology reports and provision of guideline-consistent care.

Study Design:
All computed tomography (CT) scans performed at a single tertiary care center in the outpatient or emergency room setting between 20-Feb-2024 and 20-March-2024 were processed by the AI natural language processing algorithm. CT radiology reports mentioning a lung nodule or focal indeterminate lesion were flagged. All flagged reports were reviewed by a lung nodule expert two weeks after nodule identification. IPNs were classified as “appropriately followed” if follow-up imaging, referral to a nodule clinic, or other guideline-consistent care was ordered. IPNs were classified as “not appropriately followed” if no acknowledgement of the reported nodule was documented in the electronic health record within two weeks of being flagged.

Results:
The AI software processed 76,507 unique radiology reports, identified 2,585 CT scans with chest imaging, and found 389 IPNs. Review determined that 272 (70%) nodules were appropriately followed while 117 (30%) were not appropriately followed. Of the 117 nodules without documented follow-up, 67 (57%) were > 8mm and 24 (20.5%) were > 15mm. IPNs that would not have received follow-up in the absence of the AI software generated 43 additional clinical appointments and 3 procedures.

Conclusion:
At a large tertiary care center, 30% of clinically significant incidental pulmonary nodules that would have otherwise been missed were brought to the attention of lung nodule clinicians by an AI software, allowing for initiation of appropriate follow-up.
Genetics of Prader–Willi and Angelman syndromes: 2024 update
Authors: Godler David E. , Singh Deepan , Butler Merlin G. 
Published: January 2025

Purpose of review
Prader–Willi (PWS) and Angelman (AS) syndromes arise from errors in 15q11-q13 imprinting. This review describes recent advances in genomics and how these expand our understanding of these rare disorders, guiding treatment strategies to improve patient outcomes.

Recent findings
PWS features include severe infantile hypotonia, failure to thrive, hypogonadism, developmental delay, behavioral and psychiatric features, hyperphagia, and morbid obesity, if unmanaged. AS presents severe intellectual disability, motor dysfunction, seizures, absent speech, and a characteristic happy demeanor. Standard-of-care testing involves SNRPN promoter methylation, microarray and genomic analyses for individuals presenting with these features. These tests identify syndromic-specific DNA methylation patterns and molecular genetic classes responsible for disease etiology. This review provides an update on studies of genotype–phenotype relationships and novel genomic technologies used for diagnostic purposes.

Summary
We give an overview and update on the genetics and underlying mechanisms associated with symptoms and potential treatments with focus on features reported to be different between specific molecular genetic classes. The review also describes laboratory testing methods for diagnosis of these imprinting disorders with implications for clinical practice.
grepq: A Rust application that quickly filters FASTQ files by matching sequences to a set of regular expressions
Authors: Crosbie Nicholas D. 
Published: January 2025

AbstractRegular expressions (regex) (Kleene 1951) have been an important tool for finding patterns in biological codes for decades (Hodgman 2000 and citations therein), and unlike fuzzy-finding approaches, do not result in approximate matches. The performance of regular expressions can be slow, however, especially when searching for matching patterns in large files.grepqis a Rust application that quickly filters FASTQ files by matching sequences to a set of regular expressions.grepqis designed with a focus on performance and scalability, is easy to install and easy to use, enabling users to quickly filter large FASTQ files, to enumerate named and unnamed variants and update the order in which patterns are matched against sequences through in-builttuneandsummarisecommands.grepqis open-source and available onGitHubandCrates.io.
The Demodifier: a tool for screening modification-induced alternate peptide taxonomy in palaeoproteomics
Authors: Evans Miranda 
Published: January 2025

AbstractIn palaeoproteomic research, the accuracy of taxonomic matches is crucial, as research questions frequently hinge on which species were utilised by ancient people. However, protein modifications including deamidation of glutamine and asparagine, and conversion of glutamine or glutamic acid to pyroglutamic acid, can change the sequence of peptides, leading to spurious taxonomic detections and potentially inaccurate archaeological interpretations. While a handful of examples of this phenomenon have been reported in the literature, the issue is potentially much wider reaching than currently realised. In reality, any time a peptide containing a deamidated glutamine or asparagine residue, an unmodified glutamic acid or aspartic acid residue, or a pyroglutamic acid modification is detected by proteomic search software, the sequence, and therefore potentially its taxonomy, may be incorrect, which could potentially lead to unsound archaeological interpretations.The Demodifieris a fast, open-access tool which solves this issue by screening for modification-induced alternate peptide taxonomy, enabling archaeologists to make informed interpretations of the taxonomies of proteins detected in ancient samples. To assess its utility,the Demodifieris tested against an archaeological dataset containing all unique peptides reported in palaeoproteomic studies of dental calculus and vessels. The results reveal that modification-induced alternate peptide taxonomies are severely under-reported, occurring 15% more frequently than previously understood. Modifications were found to produce three different types of inaccurate taxonomic matches: those which yielded completely different taxonomic lowest common ancestors to the input peptide, those which were more taxonomically specific than the input peptide, and those which were less taxonomically specific than the input peptide.The Demodifiertherefore enables the detection of potentially inaccurate peptide taxonomies, avoiding spurious archaeological interpretations in future studies.
Macromolecular crystallography from an industrial perspective – the impact of synchrotron radiation on structure-based drug discovery
Authors: Käck H. , Sjögren T. 
Published: January 2025

Structure-based drug design has been an integral part of drug discovery for over three decades, contributing to the development of numerous approved drugs. Here we discuss the evolution, as well as the current state, of structure-based drug design within the pharmaceutical industry, using data from AstraZeneca's internal repository for crystal structures to provide additional context. Over the past 20 years, the company has transitioned from a mixed in-house and synchrotron data collection model to a `synchrotron-only' approach, enabled by technological advancements at synchrotron facilities. We provide real-world examples of structure delivery to projects, including a high-throughput project and a case where a single structure was pivotal for discovering a candidate drug. We conclude that, despite recent developments in single-particle cryo-EM and deep-learning structure prediction methods, macromolecular crystallography remains a critical tool for drug discovery.
Identification of off-site construction disputes: technical, managerial and external dispute causes
Authors: Yildiran Merve Pelinsu , Demirdogen Gokhan 
Published: January 2025

PurposeWhile off-site construction (OSC) offers a promising solution to many problems plaguing traditional construction (e.g. low productivity, waste and safety risks), a lack of standards and knowledge about OSC, especially regarding disputes, hinders its wider adoption. This study aims to address this gap by identifying and analyzing the importance levels of technical, managerial and external disputes specific to OSC projects.Design/methodology/approachThree steps methodology was employed in the study. Focus group discussion (FGD) technique was used to identification and finalize dispute causes found from literature and collect data for the next step. In the study, two multi-criteria decision-making MCDM (methods) [a hybrid approach-Pythagorean fuzzy analytic hierarchy process (AHP) and fuzzy Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS)] were employed. While Pythagorean fuzzy AHP was used to calculate the weights of criteria, fuzzy TOPSIS analysis was used to calculate the weights of main and sub-dispute causes. Instead of using the classical AHP method, the Pythagorean fuzzy AHP method was employed due to its superiority in capturing the inherent uncertainty and ambiguity of decision-makers, giving flexibility to decision-makers with linguistic variables instead of expecting exact evaluation scores and flexibility in the integration with other methods. During the analysis of the weights of the main and sub-dispute causes, the fuzzy TOPSIS method was preferred. The fuzzy TOPSIS method involves a quicker and more straightforward decision-making process. Also, the fuzzy TOPSIS method allows the consideration of numerous alternatives and evaluation criteria and uncertainty in the decision-making process.FindingsThe analysis reveals that technical disputes pose the biggest challenge in off-site construction compared to managerial or external disputes. Specifically, “late completion, delivery and installation of components” emerged as the most significant technical dispute. Within managerial disputes, “poor planning and management of the project” ranked highest, while “the complexity of legal expressions” was the most prominent external dispute factor.Originality/valueIn the literature, three studies offer some insight on OSC disputes by analyzing the litigation cases. Nonetheless, the results can be misleading, because some disputes can be resolved before the litigation process. Therefore, the study findings can aid in foreseeing technical, managerial and external factors and in generating robust OSC contracts by considering these issues.
Happy to co-create: the influence of product co-creation over consumer hedonic adaptation
Authors: Kieling Ana Paula , Boeing Ricardo 
Published: January 2025

Purpose
Researchers have been exploring the consequences of the hedonic adaptation process at length. This phenomenon is characterized by the reduction of pleasure with consumption experiences over time. Meanwhile, co-creation initiatives seem to be gaining traction in brand strategies. However, little is known about how individuals experience the co-creation effects in consumption. The purpose of this study is to analyse the impact of consumer co-creation experiences on predicting hedonic adaptation. Also, it aims to provide insights into the emotional aspects of consumption.

Design/methodology/approach
Three mixed-design experimental studies were conducted to explore the effects of co-creation on consumer hedonic adaptation, affective forecasting and emotional responses. Study 1 and Study 2 were conducted online with American participants. Study 3 was conducted in a laboratory setting in Brazil.

Findings
The research demonstrated that individuals predict that the path to consumption adaptation will be longer when co-creating their products co-create. However, this effect varies depending on the type of product. As for the emotional aspect, consumers attribute more positive emotions than negative ones in the context of co-creation.

Research limitations/implications
This study manipulated different conditions considering specific product types. Future research should apply this framework to other products and services to confirm the generalization of the study’s findings. Also, the authors encourage future studies that explore emotions in different co-creation scenarios.

Practical implications
Elucidating how co-creation impacts consumers’ hedonic adaptation empowers companies to leverage co-creation to cultivate positive consumer attitudes and brand loyalty. Marketing campaigns can highlight the emotional benefits of ownership and personalization. It also provides a sustainable perspective for companies, which seeks consumers who remain present over time and trust the company. Furthermore, co-creation can be used strategically for innovation management. By co-creating limited-edition trial products, companies can involve new customers, foster a sense of ownership and potentially mitigate hedonic adaptation, while gathering valuable insights for new product development.

Originality/value
This research advances the limited literature on co-creation and customer hedonic adaptation, which lies at the interface between consumer behaviour and product development. It explores how product co-creation affects consumers’ predictions and shopping experiences concerning pleasure decrease, including product value and company feedback. Additionally, it examines the role of emotions in co-creation and hedonic adaptation. This research contributes by demonstrating the impact of co-creation on adaptation, affective forecasting and emotional responses during consumption.
Tattoo-inspired surface texturing on oil-impregnated PTFE for advanced tribological properties
Authors: Tian Zhiqing , Xu Bin , Fan Xiaobing , Pan Bingli , Zhao Shuang , Wang Bingchan , Liu Hongyu 
Published: January 2025

Purpose
This paper aims to investigate the crucial roles of textured surfaces on oil-impregnated polytetrafluoroethylene (PTFE) created by a facile tattoo strategy in improving tribological properties.

Design/methodology/approach
Pored PTFE (PPTFE) was prepared by mixing powder PTFE and citric acid and experienced a cold-press sintering molding process. Subsequently, textured surfaces were obtained with using a tattoo strategy. Surface-textured PPTFE was thus impregnated with polyethylene glycol 200, yielding oil-impregnated and pore-connected PPTFE.

Findings
This study found that oil-impregnated and surface-textured PPTFE exhibited excellent tribological performances with an 82% reduction in coefficient of friction and a 72.5% lowering in wear rate comparing to PPTFE.

Originality/value
This study shows an efficient strategy to improve the tribological property of PTFE using a tattoo-inspired surface texturing method.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-10-2024-0378/
CEO duality in family firms: implications for earnings management and firm performance in Thai market
Authors: Kitiwong Weerapong , Prasertsoontorn Thanu , Ratsamewongjan Ausanee , Inya Puritud , Jiraporn Pornsit 
Published: January 2025

Purpose
As the debate over CEO duality’s impact on firm performance is still ongoing, the purpose of this study is to redefine CEO duality in Thai family firms and examine its impact on the relationship between earnings management and firm performance.

Design/methodology/approach
This study uses a sample of 1,360 firm-year observations from listed firms on the Stock Exchange of Thailand. A fixed effect regression is used to obtain the empirical results. The results of this study are further validated using two-stage least squares estimation, subsample regression and an alternative measure of family firms.

Findings
This study finds that firms with CEO duality are more likely to engage in REM, supporting Agency Theory. However, family-controlled firms with CEO duality engage less in REM in pursuit of firm performance. This study’s findings highlight the potential benefits of CEO duality in family firms as a mechanism to support Socioemotional Wealth of the controlling family. Therefore, the mandatory ban on CEO duality may have unintended consequences for family firms.

Originality/value
This paper provides further evidence on the impact of CEO duality on the relationship between earnings management and firm performance in Thailand’s family-dominated stock market. A new definition of CEO duality is proposed, including firms where the CEO is related to the chair of the board. This boarder definition provides more comprehensive measurement compared to the traditional definition which may fail to capture the full scope of influence exerted by controlling family, as they may obscure CEO duality by appointing individuals with kinship ties to the CEO as the chair of the board.
Digital inventory audits: an alternative approach to physical observation in audit evidence gathering
Authors: Fotoh Lazarus Elad 
Published: January 2025

PurposeThis study examines whether digital streaming and observation technologies can serve as an alternative approach for collecting inventory audit evidence, the challenges faced in their adoption and the factors contributing to their non-adoption.Design/methodology/approachThis study adopts a two-stage, mixed-method approach, beginning with pilot study interviews that informed the comprehensive survey with qualitative and quantitative data. Quantitative data were analyzed using descriptive statistics, t-tests and Pearson’s correlation coefficient, while qualitative data were analyzed using qualitative content analysis.FindingsOur findings revealed a positive perspective concerning the effectiveness and reliability of these technologies for inventory audits and the efficiency of internal controls within them, despite challenges such as obtaining a holistic view of the warehouse, observing obsolescence, ensuring inventory completeness and general reliability concerns. Additionally, preferences for physical inventory audits and skepticism about these technologies’ potential to enhance audit quality were identified as factors contributing to their non-adoption.Research limitations/implicationsThese findings have important implications for cost-conscious firms because they reveal that carefully adopting intermediate technologies can enhance the audit process. Our findings are relevant to audit regulators and firms interested in determining whether such technologies enhance audit efficiency and quality. This study highlights the need for updated auditing standards and directives and technologies that meet auditing requirements.Originality/valueThis study contributes to the literature by uncovering whether less advanced technologies can be used as an alternative approach to collect audit evidence. Consequently, the finding adds to the growing body of literature underscoring the potential of technologies, even less sophisticated ones, to enhance the efficiency and effectiveness of audits, despite their challenges. Additionally, it underscores the need for clear regulatory standards, suggests that auditors embrace emerging technologies and acquire relevant skills and offers insights for technology developers on audit firms’ concerns regarding digital technologies.
Principals’ distributed leadership and the effectiveness of school innovation management: the mediating role of school organisational culture
Authors: Lu Shao-Hung , Chen Chien-Chih 
Published: January 2025

PurposeThis study explored the relationships between principals’ distributed leadership, school organisational culture and the effectiveness of school innovation management. A questionnaire was administered to gather data from public junior high school teachers in Taiwan.Design/methodology/approachUsing the stratified random sampling method, 1,557 questionnaires were sent to 98 schools in Taiwan, and 1,018 valid questionnaires were obtained. All data were analysed using descriptive statistics and structural equation modelling.FindingsSchool organisational culture significantly mediated the relationship between principals’ distributed leadership and the effectiveness of school innovation management. This mediating role was confirmed through multiple mediation analyses, highlighting the essential link between leadership practices and school innovation outcomes.Originality/valueThis study provides new insights into how distributed leadership by school principals can enhance the effectiveness of school innovation management by cultivating a solid organisational culture. The results underscore the importance of distributed leadership in fostering an environment conducive to school innovation.