bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinics Optimizing MEthadone Take-homes for opioid use disorder (COMET): Protocol for a stepped-wedge randomized trial to facilitate clinic level changes
Authors: Choi Sugy , O’Grady Megan A. , Cleland Charles M. , Knopf Elizabeth , Hong Sueun , D’Aunno Thomas , Bao Yuhua , Ramsey Kelly S. , Neighbors Charles J. 
Published: June 2023

Introduction
Regulatory changes made during the COVID-19 public health emergency (PHE) that relaxed criteria for take-home dosing (THD) of methadone offer an opportunity to improve quality of care with a lifesaving treatment. There is a pressing need for research to study the long-term effects of the new PHE THD rules and to test data-driven interventions to promote more effective adoption by opioid treatment programs (OTPs). We propose a two-phase project to develop and test a multidimensional intervention for OTPs that leverages information from large State administrative data.

Methods and analysis
We propose a two-phased project to develop then test a multidimensional OTP intervention to address clinical decision making, regulatory confusion, legal liability concerns, capacity for clinical practice change, and financial barriers to THD. The intervention will include OTP THD specific dashboards drawn from multiple State databases. The approach will be informed by the Health Equity Implementation Framework (HEIF). In phase 1, we will employ an explanatory sequential mixed methods design to combine analysis of large state administrative databases—Medicaid, treatment registry, THD reporting—with qualitative interviews to develop and refine the intervention. In phase 2, we will conduct a stepped-wedge trial over three years with 36 OTPs randomized to 6 cohorts of a six-month clinic-level intervention. The trial will test intervention effects on OTP-level implementation outcomes and patient outcomes (1) THD use; 2) retention in care; and 3) adverse healthcare events). We will specifically examine intervention effects for Black and Latinx clients. A concurrent triangulation mixed methods design will be used: quantitative and qualitative data collection will occur concurrently and results will be integrated after analysis of each. We will employ generalized linear mixed models (GLMMs) in the analysis of stepped-wedge trials. The primary outcome will be weekly or greater THD. The semi-structured interviews will be transcribed and analyzed with Dedoose to identify key facilitators, barriers, and experiences according to HEIF constructs using directed content analysis.

Discussion
This multi-phase, embedded mixed methods project addresses a critical need to support long-term practice changes in methadone treatment for opioid use disorder following systemic changes emerging from the PHE—particularly for Black and Latinx individuals with opioid use disorder. By combining findings from analyses of large administrative data with lessons gleaned from qualitative interviews of OTPs that were flexible with THD and those that were not, we will build and test the intervention to coach clinics to increase flexibility with THD. The findings will inform policy at the local and national level.
An Unusual Cause of Intractable Hiccups
Authors: Butt Edward , Zamora Ernesto , Shabot J. Marc 
Published: June 2023

ABSTRACT
Hiccups are a minor nuisance for most people and usually resolve within minutes. However, for some, they can persist for years and result in severe symptoms and even death. This case report describes a patient found to have a mediastinal lipoma resulting in intractable hiccups. The discussion highlights the pathophysiology, etiologies, and treatments of hiccups.
Korosi Besi dengan Elektrolit H2SO4 dan Karakterisasi Produk
Authors: Sianturi Richard Leonardo , Suyati Linda , Astuti Yayuk 
Published: June 2023

Telah dilakukan penelitian tentang penentuan laju reaksi korosi pada besi dalam air dan elektrolit asam sulfat. Penelitian ini bertujuan untuk menentukan laju korosi dengan menggunakan metode pengurangan berat, menentukan karakterisitik produk dengan FTIR untuk mengidentifikasi gugus fungsi dari produk, menentukan karakteristik XRD untuk mengetahui struktur lingkup material dari produkdan menentukan kinetika reaksi produk terbaik. Metode yang dilakukan pada penelitian ini terdiri dari 3 tahap, yaitu preparasi larutan H2SO4 0.0675M, 0.125M, 0.25M, 0.5M dan 1M, karakterisasi produk dan uji kinetika reaksi dengan variasi waktu 0, 15, 30, 45, 60 dan 75 menit. Hasil penelitian diperoleh endapan warna coklat dan karakterisasi FTIR Fe2O3 terlihat pada puncak 586 cm-1 Produk hasil reaksi antara besi dengan H2SO4 muncul puncak yang sedikit bergeser pada sudut 2θ 24,10o, 32,90odan 49,55o. Lalu pada hasil reaksi korosi besi dengan H2O muncul puncak sudut 2θ pada 24,36o, 33,24odan 49,43o. Peningkatan kecepatan korosi seiring dengan meningkatnya konsentrasi dari larutan asam sulfat. Konstanta laju order satu dan dua berturut-turut sebesar 1.28 x 10-3 menit-1 dan 2,9 x 10-4 M-1 menit-1.
Instrumented treadmill for run biomechanics analysis: a comparative study
Authors: Bravi Marco , Santacaterina Fabio , Bressi Federica , Morrone Michelangelo , Renzi Andrea , Di Tocco Joshua , Schena Emiliano , Sterzi Silvia , Massaroni Carlo 
Published: June 2023

Abstract
This study aims compare the spatiotemporal and kinematic running parameters obtained by the WalkerView (Tecnobody, Bergamo, Italy) with those recorded by a optoelectronic 3D motion capture system. Seventeen participants were simultaneously recorded by the WalkerView and a motion capture system during running tests on the WalkerView at two different speeds (i.e., 8 km/h and 10 km/h). Per each parameter and speed the Root Mean Square Error (RMSE), the intraclass correlation coefficient (ICC), and the mean of the difference (MOD) and limits of agreement (LOAs) indexes obtained from Bland-Altman analysis were used to compare the two systems. ICCs show an excellent agreement for the mean step time and the cadence at both testing speeds (ICC=0.993 at 8 km/h; ICC=0.998 at 10 km/h); a lower agreement was found for all the kinematic variables. Small differences for some spatio-temporal parameters and greater differences for the kinematic variables were found. Therefore, WalkerView could represent a practical, accessible, and less expensive tool for clinicians, researchers, and sports trainers to assess the characteristics spatio-temporal parameters of running in non-laboratory settings.
Risk management based on the best value approach and its application in conditions of the Czech Republic
Authors: Marvan Petr , Hromádka Vít , Vítková Eva 
Published: June 2023

Abstract
This study focuses on the issue of the best value approach (BVA) method in the public procurement and on the European experience with the implementation of the BVA method, with a focus on the use of this method in the Czech Republic. The key topic here is the effort to manage the risks of the construction project already at the stage of preparation and tender for suppliers of construction works or services, namely, for public contracts evaluated through the BVA. The findings show that public procurement tenderers often misunderstand the concept of project risk as managerial, temporal, economic, or qualitative risk. Case studies show reserves and possibilities for improvement. The goal of the study is to provide a framework for understanding and explaining the principles and methods of evaluating a qualitative criterion in the form of the risk assessment plan.
Analysis of mango fruit surface temperature using thermal imaging and deep learning
Authors: Pugazhendi Pathmanaban , Balakrishnan Kannaiyan Gnanavel , Anandan Shanmuga Sundaram , Somasundaram Chermadurai 
Published: June 2023

Abstract
Thermal imaging has the potential to measure the object’s surface temperature. This study investigated the thermal behavior of mango fruit stored in a refrigerated environment. Thermal images of the fruit were collected with sufficient quality by supplying hot air to the acquisition environment. Grey-Level Co-occurrence Matrix (GLCM) features of mango images were determined to distinguish the subtle and noticeable changes. The thermal images were analyzed to find the temperature difference between the different regions of the fruit. The temperature of the bruise boundary (T

bd
) was higher than the bruised center (T

C
) throughout the storage period. In addition, an enhanced deep-learning model was used to predict the damaged mango. Over 10 days, 3500 thermal images were obtained from the 400 mangoes. In that, 80 % of the images were used for training, 10 % for testing, and 10 % for validation. The model achieved a classification accuracy of 99.6 %.
Extraction of uranium and rare earths from mineralized ferruginous sandstone, southwestern Sinai
Authors: El Hady Saleh Mohamed 
Published: June 2023

Abstract
A technological sample assaying 943 ppm U and about 0.97 % RE2O3 in a mineralized ferruginous sandstone has been collected from Wadi Sedri area of southwestern Sinai. The XRD analysis has releaved the presence of uranium minerals namely; coffinite and sodium meta-autonite but the rare earths adsorbed on the clay minerals inter the ore sample. Leaching of uranium and rare earths from the studied sample is based on ferric sulfate salt. The relevant conditions e.g. (6 g/L ferric sulfate concentration, 1/5 S/L ratio, time 8 h, T = 80 °C and 7.5 g/L H2SO4 concentration) of the ferric ion leaching for uranium and rare earths have been optimized. From the obtained leach liquor, the rare earths are precipitated as oxalates. This is followed by uranium recovery using anion exchange resin as impregnated Lewatite Monoplus M 500/Alamine 304. Therefore, highly pure products of uranium and rare earths have been obtained and chemically analyzed.
Mechanical property improvement of oil palm empty fruit bunch composites by hybridization using ramie fibers on epoxy–CNT matrices
Authors: Wulan Praswasti Pembangun Dyah Kencana , Yolanda Yogi 
Published: June 2023

Abstract
Oil palm empty fruit bunches (OPEFBs) can be transformed into composite boards with higher selling value when their cellulose is used as a fiber. Manufacturing composites with hybridization techniques can improve their properties. This study combined OPEFBs and ramie fibers in an epoxy–carbon nanotube (CNT) matrix. The proportion of OPEFBs and ramie fibers was varied (3:7, 5:5, and 7:3), with a total fiber content of 10% by volume and a matrix of 90% by volume. Alkali treatment using NaOH solution was applied to the fiber to remove impurities from the surface. CNTs were functionalized using nitric acid followed by hydrogen peroxide to improve compatibility. Surface treatment was conducted on fibers and CNTs to increase the bonds between these components in the composite material. The hybridization of OPEFBs/ramie fibers improved the tensile strength in the 3:7TR, 5:5TR, and 7:3TR composites by 127, 37, and 12%, respectively, compared to the 10T composite. The flexural strength of the 5:5TR hybrid composite increased by 120%, and that of the 3:7TR and 7:3TR composites increased by 83% against the 10R composite. The 3:7TR hybrid composite showed the best mechanical properties.
Effects of conditioned pain modulation on Capsaicin-induced spreading muscle hyperalgesia in humans
Authors: Schliessbach Jürg , Siegenthaler Andreas , Graven-Nielsen Thomas , Arendt-Nielsen Lars , Curatolo Michele 
Published: June 2023

Abstract

Objectives
Muscle pain can be associated with hyperalgesia that may spread outside the area of primary injury due to both peripheral and central sensitization. However, the influence of endogenous pain inhibition is yet unknown. This study investigated how endogenous pain inhibition might influence spreading hyperalgesia in experimental muscle pain.

Methods
Conditioned pain modulation (CPM) was assessed in 30 male volunteers by cold pressor test at the non-dominant hand as conditioning and pressure pain thresholds (PPT) at the dominant 2nd toe as test stimuli. Subjects were classified as having inhibitory or facilitating CPM based on published reference values. Subsequently, muscle pain and hyperalgesia were induced by capsaicin injection into the non-dominant supraspinatus muscle. Before and 5, 10, 15, 20, 30, 40, 50 and 60 min later, PPTs were recorded at the supraspinatus, infraspinatus and deltoid muscle, ring finger and toe.

Results
Compared to baseline, PPTs decreased at the supraspinatus, infraspinatus and deltoid muscle (p≤0.03), and increased at the finger and toe (p<0.001). In facilitating CPM (n=10), hyperalgesia occurred at 5, 10, 15, 20 and 40 min (p≤0.026). In inhibitory CPM (n=20), hyperalgesia only occurred after 10 and 15 min (p≤0.03). At the infraspinatus muscle, groups differed after 5 and 40 min (p≤0.008).

Conclusions
The results suggest that facilitating CPM is associated with more spreading hyperalgesia than inhibitory CPM. This implies that poor endogenous pain modulation may predispose to muscle pain and spreading hyperalgesia after injury, and suggest that strategies to enhance endogenous pain modulation may provide clinical benefits.
LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity
Authors: Christova Tania , Ho Stephanie KY , Liu Ying , Gill Mandeep , Attisano Liliana 
Published: June 2023

AbstractThe establishment of axon‐dendrite polarity is fundamental for radial migration of neurons, cortical patterning, and formation of neuronal circuits. Here, we show that the receptor tyrosine kinases, Ltk and Alk, are required for proper neuronal polarization. In isolated primary mouse embryonic neurons, the loss of Ltk and/or Alk causes a multiple axon phenotype. In mouse embryos and newborn pups, the absence of Ltk and Alk delays neuronal migration and subsequent cortical patterning. In adult cortices, neurons with aberrant neuronal projections are evident and axon tracts in the corpus callosum are disrupted. Mechanistically, we show that the loss of Alk and Ltk increases the cell‐surface expression and activity of the insulin‐like growth factor 1 receptor (Igf‐1r), which activates downstream PI3 kinase signaling to drive the excess axon phenotype. Our data reveal Ltk and Alk as new regulators of neuronal polarity and migration whose disruption results in behavioral abnormalities.
Desmatamento e a importância das áreas de proteção ambiental no Estado de São Paulo
Authors: Gotardi Tamires Regina , Primos Mariana Patty Guilger 
Published: June 2023

As estradas de ferro, assim como outros veículos de progresso do país, representam grande parte do desmatamento da vegetação nativa, para a abertura de caminhos e instalação de infraestrutura. Posteriormente com a colaboração de outros fatores, como a agropecuária e o extrativismo, que dizimaram grande parte da vegetação nativa. Com a devastação, foi necessária a implantação de hortos florestais, os quais foram desenvolvidos para produção de eucaliptos e pinus, com finalidade da comercialização madeireira. Após o desuso pela ferrovia, estas áreas serviram como base para a criação das Unidades de Conservação. Perante disso, esse trabalho tem por finalidade elaborar uma análise da história do desmatamento com ênfase no Estado de São Paulo e relação com as Unidades de Conservação, por meio do processo de sua respectiva implantação, extração ilegal da madeira, danos aos ecossistemas, como combatê-lo e a importância das áreas protegidas. Metodologicamente realizaram-se estudos teóricos por meio de pesquisas bibliográficas em sites, artigos científicos, teses, Legislação como intuito de debater sobre o desmatamento e ressaltar a importância da preservação. Como resultado estimasse a disseminação do conhecimento histórico das áreas e a valorizar as unidades de conservação para o bem-estar social.
PALAVRAS-CHAVE: Unidades de Conservação; Desmatamento; Preservação;
Legislação Urbanística e Variações na Ocupação do Solo: Trecho do Bairro de Botafogo, Rio de Janeiro
Authors: Hamada Luciana , Loyola Lucas Vicente , Freitas Wagner Guimarães , Drach Patricia 
Published: June 2023

O presente trabalho analisa um trecho urbano do Bairro de Botafogo, localizado na Zona Sul da cidade do Rio de Janeiro, com o objetivo de entender e correlacionar as mudanças na morfologia urbana associadas às alterações na legislação urbanística ao longo do tempo. Foram realizados levantamentos acerca da legislação e de mapas cadastrais pertinentes ao trecho urbano de estudo para interpretação morfológica em períodos distintos, buscando mapear as mudanças nos aspectos de ocupação do solo, dentre eles os gabaritos e afastamentos. O reconhecimento das mudanças ocorridas no trecho urbano, ao longo de 40 anos, possibilitou a percepção da importância de se olhar para a cidade, independente do recorte geográfico, e compreender como determinações e características do passado influenciam o presente e influenciarão o futuro, uma vez que o meio urbano está em constante transformação, com a finalidade de atender as demandas e especificidades de cada geração.
PALAVRAS-CHAVE: Legislação Urbanística. Gabaritos e Afastamento. Densidade Urbana.
O Fenômeno de Ilhas de Calor e o Papel da Arborização Urbana Para Mitigá-lo: Um Estudo em Ituverava, Região Nordeste do Estado de São Paulo, Brasil
Authors: Costa Fabiana Gorricho , Garcia Lucas Henrique do Carmo , Ribeiro Andreza Portella , Oliveira Anderson de 
Published: June 2023

O crescimento das cidades e o seu entorno tem, em sua relação com o ambiente natural, causado impactos ambientais que transformam severamente o clima local e influenciam a qualidade de vida das pessoas. O objetivo desta pesquisa foi analisar o fenômeno Ilhas de Calor Urbanas (ICU) na cidade de Ituverava/SP, por meio da análise comparativa em imagens de satélite, dos anos de 2014 e 2021, e indicar o potencial da infraestrutura verde urbana para reduzir os efeitos das ilhas de calor. Espera-se que esta pesquisa forneça informações que possibilitem destacar a obrigatoriedade do fortalecimento das políticas públicas verdes brasileiras no contexto urbano. Pode-se considerar que no município ocorre o fenômeno Ilhas de Calor Urbano, apresentando uma sensação de desconforto térmico, devido às áreas degradadas, solo exposto do entorno da área urbana, ausência de sombreamento de árvores, etc. A avaliação usando as simulações do software I-Tree Canopy também contribuiu para evidenciar os potenciais benefícios da arborização urbana, em relação à qualidade do ar, na qual para mitigar os efeitos do fenômeno e proporcionar conforto térmico em áreas urbanas, é urgente a adoção de medidas para aumentar e distribuir melhor as áreas com vegetação verde, principalmente em volta e no centro da cidade.
PALAVRAS-CHAVE: Sensoriamento remoto, Ilha de calor urbano, Arborização urbana, I-Tree canopy, Ituverava-SP.
Features of clinical and morphological manifestations of pneumonia complicated by exudative pleuritis in senile patients
Authors: Stogova N. A. 
Published: June 2023

Globally, pneumonia complicated by exudative pleurisy is often recognised too late and inadequately treated in senile patients.Purpose. To study the clinical manifestations, diagnosis, and treatment of community-acquired pneumonia complicated by exudative pleurisy in the senile.Methods. Archived case histories from the period 2006 – 2022 were used to conduct a comparative study of these clinical manifestations and the outcomes of treatment of community-acquired pneumonia complicated by pleurisy was carried out in 33 patients aged 75 – 88 years and 50 patients aged 18 – 34 years.Results. Acute onset of pneumonia complicated by pleurisy was less common in senile age than in young people (60.6% vs 82.0%; p < 0.05), pneumonia proceeded without an increase in body temperature more often than in young people (24.2% vs 4.0%; p < 0.01), chest pain was less common (60.6% vs 90.0%; p < 0.01), rales in the lungs were heard more often on auscultation (48.5% vs 22.0%; p < 0.05). In the analysis of peripheral blood in senile age, leukocytosis (33.3% vs 66.0%; p < 0.05) and a leftward shift in the leukocyte formula (6.1% vs 24.0%; p < 0.05) occurred less frequently in senile patients. Pneumonia occurred against diseases of cardiovascular system(84.9% vs 8.0%; p < 0.01), gastrointestinal tract (42.4% vs 18.0%; p < 0.05) and urinary system(27.3% vs 4.0%; p < 0.01), and lingered more often in senile people (36.4% vs 10.0%; p < 0.05) than in young ones. In senile age, pneumonia was combined with pericarditis in 6.06% of cases, and in 21.2% it occurred against a background of residual changes after previous respiratory tuberculosis, which was not observed in young age.Conclusion. Antibacterial therapy, taking into account the sensitivity of sputum microflora to drugs, combined with regular aspiration of pleural exudate, made it possible to cure all senile patients without surgical intervention. The severity of residual pleural changes was similar to that in young people.
Nutritional Status And Quality Of Food In Childeen Under Five Years Of Age In Benin
Authors: Agossou Esse , Akotegnon Rodrigue , Hoteyi Ismael , Sezan Alphonse 
Published: June 2023

Background Malnutrition is a public health problem in developing countries. The aim of our work is to assess the nutritional status and dietary quality of children under 5 years of age.
Objective This study focused on children seen in the pediatric department of the Saint Martin de Papanè Hospital during the period from April 6 to July 6, 2021. It is a descriptive and analytical survey by questionnaire on 208 children aged 0 to 59 months.
Results The evaluation of the nutritional status of these children under 5 years of age is predominantly male (sex ratio 1.2) and the analysis of the answers to the questions asked of their respective mothers has made it possible to better appreciate the nutritional situation of the children in this study area and to identify the determinants associated with this malnutrition. The study revealed that 74.88% of children are stunted, 90.34% suffer from global acute malnutrition and 79.43% are underweight. Exclusive breastfeeding is very rare, with only 11% of children between the ages of 0 and 6 months receiving only breast milk. The evaluation of dietary diversity reveals that 76.92% of children have a low dietary diversity. In fact, 86% of the children surveyed receive an inadequate complementary diet based on cereals and 67.31% are subjected to the family dish that is poor in nutrients. 59% of the homes in which the children live are more than 5 km from the health centers, 56.73% of the children's mothers have no education and 25% have a low level of education.
Conclusion According to our results, poor weaning practices, diseases, sibling rank and low level of education of mothers are the associated determinants of malnutrition observed in the study population in this area of northeast Benin.