bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of inappropriate cause-of-death certification on mortality from cardiovascular disease and diabetes mellitus in Tonga
Authors: Figueroa Carah , Linhart Christine , Dearie Catherine , Fusimalohi Latu , Kupu Sioape , Morrell Stephen , Taylor Richard 
Published: September 2023

Abstract
Background:
Cardiovascular disease (CVD) and diabetes mellitus are major health issues in Tonga and other Pacific countries, although mortality levels and trends are unclear. We assess the impacts of cause-of-death certification on coding of CVD and diabetes as underlying causes of death (UCoD).
Methods:
Tongan records containing cause-of-death data (2001–2018), including medical certificates of cause-of-death (MCCD), were assigned an UCoD using International Classification of Diseases 10th revision (ICD-10) coding. Deaths without recorded cause were included to ascertain total mortality. Alternative UCoD were assigned following reallocation of diabetes and hypertension from Part 1 of the MCCD (direct cause) to Part 2 (contributory cause) if potentially fatal complications were not recorded. CVD and diabetes mortality estimated using alternative certification was compared with estimates using unaltered certification.
Results:
ver 2001–18, in ages 35-59 years, alternative CVD mortality was higher than unaltered CVD mortality in men (p=0.043) and women (p=0.15); for 2010-18, alternative versus unaltered measures in men were 3.3/103 (95%CI: 3.0-3.7/103) versus 2.9/103 (95%CI: 2.6-3.2/103), and in women were 1.1/103 (95%CI: 0.9-1.3/103) versus 0.9/103 (95%CI: 0.8-1.1/103). Conversely, alternative diabetes mortality rates were significantly lower than the unaltered rates over 2001–18 in men (p<0.0001) and women (p=0.013); for 2010-18, these measures in men were 1.3/103 (95%CI: 1.1-1.5/103) versus 1.9/103 (95%CI: 1.6-2.2/103), and in women were 1.4/103 (95%CI: 1.2-1.7/103) versus 1.7/103 (95%CI: 1.5-2.0/103). Diabetes mortality rates increased significantly over 2001–18 in men (unaltered: p<0.0001; alternative: p=0.0007) and increased overall in women (unaltered: p=0.0015; alternative: p=0.014).
Conclusions:
Diabetes reporting in Part 1 of the MCCD, without potentially fatal diabetes complications, has led to over-estimation of diabetes, and under-estimation of CVD, as UCoD in Tonga. This indicates the importance of controlling various modifiable risks for atherosclerotic CVD (including stroke) including hypertension, tobacco use, and saturated fat intake, besides obesity and diabetes. Accurate certification of diabetes as a direct cause of death (Part 1) or contributory factor (Part 2) is needed to ensure that valid UCoD are assigned. Examination of multiple cause-of-death data can improve understanding of the underlying causes of premature mortality to better inform health planning.
Long-term outcomes of nephrectomy before kidney transplantation in patients with polycystic kidney disease
Authors: First Leia , Schwartz Doron , Schwartz Idit F. , Goykhman Yaacov , Baruch Roni , Ben-Bassat Orit Kliuk , Shashar Moshe , Cohen-Hagai Keren , Nacasch Naomi , Grupper Ayelet 
Published: September 2023

Abstract
Background:
Polycystic Kidney Disease (PKD) is the most common hereditary kidney disorder. In most patients the disease progresses to end stage kidney disease, which is treated preferably by kidney transplantation. In certain clinical circumstances, a pretransplant nephrectomy is indicated. Data regarding long term outcomes of pretransplant nephrectomy is limited.
In this study, we aimed to compare patient and graft survival, as well as other long-term outcomes of kidney transplantation, between patient with PKD who had a pretransplant nephrectomy and those who have not.
Methods:
A retrospective analysis of 112 adult kidney transplant recipients with PKD, 36 (32.14%) of which underwent a pretransplant nephrectomy.
Results:
In a mean follow-up period of 79 and 129 months (for patients who underwent nephrectomy and patients who did not, respectively), no significant differences were found in patient and graft survival, after adjustment to age and donor type. In addition, rate of hospitalizations, urinary tract infections requiring hospitalization, diabetes mellitus and erythrocytosis post-transplant were similar in both cohorts.
Conclusions:
Pre-transplant nephrectomy in patients with PKD is not associated with increased risk of mortality and other long term complications following kidney transplantation.
Risk factors and pathogenic bacteria of central venous catheter-associated bloodstream infection in patients with emergency hemorrhagic shock: a single-center retrospective Study from 2016 to 2022 in a Teaching Hospital in China
Authors: Zhu Jianping , Xu Yanxin , Wu Shaohong , Wang Feiyao , Zhang Weixing , Wang Ruilan 
Published: September 2023

Abstract
Objective
To investigate and analyze the risk factors and pathogenic bacteria of central venous catheter-associated bloodstream infection in patients with emergency hemorrhagic shock.
Methods
According to the inclusion criteria, 249 patients with hemorrhagic shock and central venous catheterization admitted to the emergency department of Shanghai General Hospital from June 2016 to June 2022 were retrospectively analyzed, and divided into the infection group (54 cases) and the non-infection group (195 cases) according to whether catheter-related bloodstream infection occurred.Multivariate Logistic regression was used to analyze the relationship between central venous catheter-related bloodstream infection and various influencing factors. The etiological and drug susceptibility test data of peripheral venous blood culture, puncture site samples and catheter tip samples from patients with central venous catheter-associated bloodstream infection were statistically analyzed.
Results
There were significant differences in age, catheterization location, ultrasound-guided puncture, APACHE ⅱ score, catheter indwelling time and application of broad-spectrum antibiotics between the infected group and the non-infected group (P < 0.05). Staphylococcus epidermis accounted for 44.6%, Escherichia coli 23.2%, and fungi 12.5% in 54 infected patients. The lowest resistance rate of Gram-positive cocci was to vancomycin(3.4%),followed by tetracycline 34.5%,and the highest resistance rate was to amoxicillin 100.0%.
Conclusion
The risk factors of central venous catheter-related bloodstream infection in patients with emergency hemorrhagic shock include advanced age,femoral vein catheterization,non-ultrasound-guided puncture,high APACHE ⅱ score,catheter retention time,and application of broad-spectrum antibiotics.Staphylococcus epidermis the common pathogen of central venous catheterization related infection in emergency hemorrhagic shock patients.
A Two-Pronged Approach to Understanding Reciprocity and Mental Health Relationship in Developing Countries: Evidence from Young Informal Construction Workers in Nigeria.
Authors: Oladosu Ayomide Oluwaseyi , Chanimbe Timothy 
Published: September 2023

AbstractBackgroundMental health problems disproportionately affect young people in developing countries. However, there is limited research on help-seeking behaviours and the social support systems that improve mental wellbeing among vulnerable youth populations.ObjectiveThis mixed-methods study aimed to examine the relationship between social support reciprocity and mental health among young informal construction workers in Nigeria, a population at high-risk for occupational and socioeconomic stressors.MethodsA cross-sectional survey was administered to 686 informal workers to measure reciprocity, mental health-related quality of life, and covariates. In-depth interviews with 32 participants provided qualitative context.ResultsQuantitative analyses showed 25% of participants reported poor mental health. Reciprocity positively predicted mental health after controlling for covariates. Qualitative findings revealed reciprocity occurs directly between individuals as well as indirectly through trade unions and religious groups. Indirect exchanges through groups helped address limitations of direct support due to limited resources.ConclusionsThis study fills important gaps in understanding how social relationships impact mental health in developing country contexts. Findings emphasize the role of collective action and community-based support systems in promoting mental wellbeing among vulnerable populations. Insights can inform culturally relevant, systems-level mental health interventions.
Early detection of graft incompatibility in Sweet cherry by internode association and callus fusion techniques
Authors: jalali arezoo , Ganjimoghaddam Ebrahim , marjani ali 
Published: September 2023

Abstract

Scion-rootstock incompatibility is one of the most problems in fruit trees. The study evaluated predicted compatibility/ incompatibility by internode association and callus fusion techniques. Two factorial experiments were as laid out with an incompletely randomized design (CRD) with three replications. Treatment including the first factor, four levels of sweet cherry cultivars (‘Bing’, ‘Takdaneh’, ‘Siyah Mashhad’, and ‘Adli’) and the second factor, four levels of rootstocks (‘Gisela-5’, ‘Gisela-6’, ‘Mahaleb’ (M-168), and ‘GF-305’). Results showed significant differences in total phenolic content, peroxidase, and starch content in internode association and callus fusion experiments. ‘GF-305’ (incompatible) rootstock had the lowest success rate of grafts on all cultivars, while ‘Gisela-6’ rootstock showed the highest success rate of grafts on ‘Siyah Mashhad’ and ‘Bing’ cultivars. Both experiments showed that in incompatible grafts, an increase in total phenol content and peroxidase activity and a decrease in grafts' success rate were observed. The degree of compatibility was significantly and positively correlated with the graftʼs success rate while significantly and negatively correlated with total phenol content and peroxidase activity. In both experiments, no clear trend was observed regarding starch content and graftʼs success rate. The regression analysis results showed that phenol compounds in both experiments significantly affected the graft's success rate and the degree of compatibility. Therefore, our finding leads to the conclusion that phenolic compounds (mostly) and peroxidase activity can be used to pre-screen for incompatible grafts. Moreover, the callus fusion technique can be a quick way to predict (in)compatibility of graft in sweet cherry.
Role of miR-128-3p and miR-195-5p as biomarkers of coronary artery disease In Indians: A Pilot study
Authors: Choudhury Raj Rajeshwar , Gupta Harshi , Bhushan Sudha , Singh Archna , Roy Ambuj , Saini Neeru 
Published: September 2023

Abstract

Coronary artery disease (CAD) imposes a significant economic burden in developing countries like India. Timely diagnosis and treatment should be prioritized to mitigate the disease. Current diagnostic tools being invasive and less specific raise the need to develop less invasive and more reliable molecular biomarkers. MicroRNAs (miRNAs) are an emerging class of molecules that can serve as a potential source of non-invasive biomarkers for CAD. The objective of this study was to determine the potential of circulatory miRNAs as diagnostic biomarkers in CAD. In this study, we have reported two microRNAs, miR-128-3p and miR-195-5p in the serum of CAD patients in Indian Population. A total of 54 subjects were recruited which included 33 angiographically proven CAD patients and 21 control subjects. Our results show a significant downregulation in the levels of miR-128-3p in CAD patients while there were no significant changes in the levels of miR-195-5p. Further bioinformatics analysis revealed the potential role of miR-128-3p in cholesterol homeostasis. Altered homeostasis due to cholesterol accumulation in macrophages is the driving force behind formation of foam cells which in turn accelerates the progression of CAD. Here, we have shown that miR-128-3p increases cholesterol levels in macrophages by decreasing cholesterol efflux in-vitro.
COSMIC-based mutation database enhances identification efficiency of HLA-I immunopeptidome
Authors: Wang Fangzhou , Zhang Zhenpeng , Mao Mingsong , Yang Yudai , Xu Ping , Lu Shichun 
Published: September 2023

Abstract
Background: Neoantigens have emerged as a promising area of focus in tumor immunotherapy, with several established strategies aiming to enhance their identification. Human leukocyte antigen class I molecules (HLA-I), which present intracellular immunopeptides to T cells, provide an ideal source for identifying neoantigens. However, solely relying on a mutation database generated through commonly used whole exome sequencing (WES) for the identification of HLA-I immunopeptides, may result in potential neoantigens being missed due to limitations in sequencing depth and sample quality.
Method: In this study, we constructed and evaluated an extended database for neoantigen identification, based on COSMIC mutation database. This study utilized mass spectrometry-based proteogenomic profiling to identify the HLA-I immunopeptidome enriched from HepG2 cell. HepG2 WES-based and the COSMIC-based mutation database were generated and utilized to identify HepG2-specific mutant immunopeptides.
Result: The results demonstrated that COSMIC-based database identified 5 immunopeptides compared to only 1 mutant peptide identified by HepG2 WES-based database, indicating its effectiveness in identifying mutant immunopeptides. Furthermore, HLA-I affinity of the mutant immunopeptides was evaluated through NetMHCpan and peptide-docking modeling to validate their binding to HLA-I molecules, demonstrating the potential of mutant peptides identified by the COSMIC-based database as neoantigens.
Conclusion: Utilizing the COSMIC-based mutation database is a more efficient strategy for identifying mutant peptides from HLA-I immunopeptidome without significantly increasing the false positive rate. HepG2 specific WES-based database may exclude certain mutant peptides due to WES sequencing depth or sample heterogeneity. The COSMIC-based database can effectively uncover potential neoantigens within the HLA-I immunopeptidomes.
Cross Cultural Adaptation, Reliability and Validity of the Persian Version of the University of Wisconsin Running Injury and Recovery Index
Authors: Sheikhi Bahram , Akbari Hadi , Heiderscheit Bryan 
Published: September 2023

Abstract
Background
The University of Wisconsin Running Injury and Recovery Index (UWRI) was developed to evaluate running ability after a running-related injury. The aim of this study was to translate and cross-culturally adapt the UWRI into Persian (UWRI-Persian) and to investigate its psychometric properties in patients with a running-related injury.
Methods
The UWRI-Persian was translated using the Beaton guidelines. One-hundred-and-seventy-three native Persian patients with running-related injuries were participated. The convergent validity of the UWRI-Persian was evaluated using the Pearson correlation with the pain self-efficacy questionnaire (PSEQ), Tampa scale for Kinesiophobia (TKS), and visual analogue scale (VAS). Test-retest reliability was tested among 64 patients who completed the form again after seven days.
Results
The UWRI-Persian showed excellent internal consistency for total score (α = 0.966). An excellent internal consistency (α = 0.922) was shown for psychological response and good internal consistency (α = 0.887) for running progression. The interclass correlation coefficient for the UWRI-Persian total scores was 0.965 (95% CI, 0.942 to 0.979), indicating high intra-rater reliability. The UWRI-Persian demonstrated a moderate correlation with the PSEQ (r = 0.425) and the TSK (r = 0.457). The UWRI-Persian showed a weak correlation with the VAS (r = 0.187). These findings suggest no floor or ceiling effects.
Conclusions
The UWRI is a reliable and valid tool for Persian-speaking patients with running-related injuries. The UWRI was successfully translated from English to Persian and demonstrated good to excellent internal consistency, validity and reliability with no floor or ceiling effects.
An automatic damping-matching method for eliminating 87.64% damping asymmetry of MEMS vibratory gyroscope in rate mode
Authors: Zhou Tong , Ren Jingbo , Zhou Yi , Li Yixuan , Su Yan 
Published: September 2023

Abstract

The damping asymmetry error is a prominent factor influencing the static performance of fully symmetrical Micro-Electro-Mechanical Systems (MEMS) vibratory gyroscopes. To eliminate this error and enhance the gyroscope's static performance, this paper introduces a method for real-time identification and automatic matching of the damping asymmetry error in rate mode. By leveraging the vibration characteristics of the fully symmetrical MEMS vibratory gyroscope in rate mode, dedicated online test methods are devised to determine the quality factors for both the drive and sense modes, enabling online identification of the damping asymmetry error. Furthermore, an automatic damping-matching system is devised utilizing the mechanical-thermal dissipation mechanism of a resistive damper. The effectiveness of this proposed method is validated through simulations and experiments conducted on a MEMS disk resonator gyroscope (DRG). The experimental results show an accuracy within 4% for quality factor identification, while automatic damping matching effectively reduces the damping asymmetry error by 87.64%. Employing this automatic damping-matching method successfully diminishes the zero-input bias caused by damping asymmetry error in the MEMS DRG from 0.1067°/s to 0.0249°/s and improves bias instability from 0.3985°/s to 0.1878°/s.
Treatment strategy for infantile neuroblastoma with MYCN amplification or gain based on MYCN immunohistochemistry: a report of two cases
Authors: Haga Yoichi , Nakazawa Atsuko , Okamatsu Chizuko , Matsuoka Masaki , Takahashi Hiroyuki , Kuroiwa Minoru , Ohara Akira 
Published: September 2023

Abstract
Background
MYCN-amplified neuroblastoma almost always expresses the MYCN protein. MYCN amplification is one of the crucial risk factors for a poor prognosis. However, there are scattered cases in which MYCN protein expression is absent despite MYCN amplification, making it difficult to evaluate the prognostic importance of MYCN amplification. Recently, the usefulness of MYCN protein expression in the histological diagnosis of neuroblastoma has been reported, but there are only a few cases of treatment intensity reduction based on negative protein expression despite MYCN amplification.
Case presentation:
Herein, we report two cases of infantile neuroblastoma—a 3-month-old girl and 10-month-old boy with stage 4S and 2B neuroblastoma, respectively—with MYCN amplification or gain without MYCN expression. The 3-month-old girl with stage 4S disease was initially treated with one course of chemotherapy before biopsy due to hepatomegaly causing abdominal compartment syndrome. MYCN amplification was evident, but MYCN expression was negative; therefore, treatment intensity was reduced and autologous stem cell transplantation was not performed. The 10-month-old boy with stage 2B showed MYCN gain on initial biopsy, but was negative for MYCN expression. Therefore, he was treated with conventional chemotherapy and surgery. Both patients were treated with conventional chemotherapy and 13-cis-retinoic acid without autologous stem cell transplantation. They remained disease free for 10 and 7 years post-resection, respectively. These two cases led us to speculate that MYCN protein expression more closely reflects the nature of a tumor than MYCN amplification or gain.
Conclusions
Nevertheless, chemotherapy could be optimized based on histological features and MYCN expression rather than MYCN amplification or gain. It is expected that MYCN expression will be considered as a factor in determining treatment intensity for MYCN-amplified or -gain tumors.
Jackknife empirical likelihood for variance of two sample compound Poisson processes
Authors: Cheng Conghua 
Published: September 2023

Abstract
The compound Poisson process has a wide range ofapplications in many fields. Among these applications, the varianceis a very important quantity. For financial investment event, sometimes the investors may be more concerned about the magnitude ofrisk than return. In this article, we propose a nonparametric methodbased on jackknife empirical likelihood ratio to test the differenceequality of the two variances for two compound Poisson processes. Itshows that the log-empirical likelihood ratio statistic for thedifference of two variance of two sample compound Poisson processesconverges to χ2(1)$ as t→∞ in distribution.The simulation results show that the empirical likelihood ratiomethod is applicable. The proposed method has been applied to a realdata set to illustrate the method.
2000 Mathematics Subject Classification 62M86
Medical Error Reporting Among Healthcare Workers in a Kenyan Tertiary Level Hospital: A KAP Study
Authors: Okutoyi Lydia , Godia Pamela , Adam Mary , Sitati Fred , Jaoko Walter 
Published: September 2023

Abstract
Background
Medical Error Reporting (MER) enables organizations to characterize safety events, learn from them, and mitigate their recurrence in the future. However, Medical Error Reporting is inconsistently practiced by healthcare workers. This study aimed to assess the knowledge, practice and attitude towards MER at the Kenyatta National Hospital (KNH), a tertiary care teaching and referral hospital in Kenya that serves Kenya and the East and Central African regions.
Methods
This cross-sectional study was conducted among healthcare workers at KNH between February and September 2022. Three hundred and eighty-two (382) participants were purposively sampled from different cadres and divisions of the hospital to represent the full spectrum of HCW the hospital employed. Participants were recruited via email, departmental WhatsApp groups or during departmental meetings. Data was collected via the participants’ choice of an online link or a paper pencil format using a pre-tested, self-administered questionnaire.
Results
The majority of surveyed staff 265 (71%), were aware of the need for MER and of the MER form. Two-hundred fifty-two (68%) of the participants reported having encountered MER in the past two years, yet only 138 (38.1%) had filled out a MER form to formally report the error. These 138 participants had filled out a total of 758 forms over the past two years. Most of the participants, 292 (86.1%), correctly defined patient safety. Nurses were 3 times more likely to report medical errors than doctors OR 3.26 (95% CI:1.82, 5.94)
Conclusion
The HCWs underreport medical errors at KNH. Nurses are significantly more likely than doctors to report medical errors. Improved reporting from doctors may require training to increase awareness of the existence of a reporting system and of the need to report. At the management level, there is an opportunity to develop a more positive reporting culture that will likely improve the MER systems' use.