bluuebunny/crossref_metadata_2025_split huggingface dataset:
S3‐Leitlinie Urtikaria. Teil 2: Therapie der Urtikaria – deutschsprachige Adaption der internationalen S3‐Leitlinie
Authors: Zuberbier Torsten , Altrichter Sabine , Bauer Sabine , Brehler Randolf , Brockow Knut , Dressler Corinna , Fluhr Joachim , Gaskins Matthew , Hamelmann Eckard , Kühne Kathrin , Merk Hans , Mülleneisen Norbert K. , Nast Alexander , Olze Heidi , Ott Hagen , Pleimes Marc , Ruëff Franziska , Staubach‐Renz Petra , Wedi Bettina , Maurer Marcus 
Published: February 2023

ZusammenfassungDie vorliegende Publikation ist der zweite Abschnitt der deutschsprachigen S3‐Leitlinie Urtikaria. Sie umfasst das Management der Urtikaria und sollte gemeinsam mitTeil 1der Leitlinie zur Klassifikation und Diagnostik genutzt werden. Diese Publikation wurde auf der Basis der internationalen englischsprachigen S3‐Leitlinie unter besonderer Berücksichtigung der medizinischen Gegebenheiten im deutschsprachigen Raum entsprechend den Kriterien der AWMF erstellt. Eine chronische Urtikaria hat einen hohen Einfluss auf Lebensqualität und Leistungsfähigkeit der Patienten. Sofern kausale Faktoren nicht beseitigt werden können, ist daher eine effektive symptomatische Behandlung notwendig. Die empfohlene Therapie der ersten Wahl ist die Gabe von nicht sedierenden H1‐Antihistaminika der neuen Generation. Wenn die Standarddosierung nicht ausreichend wirksam ist, sollte die Dosis bis auf das Vierfache erhöht werden. Bei Patienten, die auch auf eine solche Behandlung nicht ansprechen, sind Therapeutika der zweiten Wahl zusätzlich zu Antihistaminika im Rahmen des Therapiealgorithmus zunächst Omalizumab und, bei Versagen dieser Therapie, Ciclosporin. Weitere Therapeutika mit geringer Evidenz sollten nur bei Versagen aller Therapien des konsentierten Algorithmus verwendet werden. Dabei sollten sowohl das Nutzen‐Risiko‐Profil als auch die Kosten berücksichtigt werden. Kortikosteroide werden für die Langzeitbehandlung aufgrund ihrer unvermeidbaren schweren Nebenwirkungen nicht empfohlen.
Psychosocial factors associated with pain outcomes in patients with painful temporomandibular disorders and headaches
Authors: van der Meer Hedwig A , Tol Cornel H. M , Speksnijder Caroline M , van Selms Maurits K. A , Lobbezoo Frank , Visscher Corine M 
Published: February 2023

AbstractThe objective of this study was to assess the association between psychosocial factors (in terms of anxiety, somatization, depression, and optimism) and pain (in terms of headache pain intensity and pain‐related disability), in patients with a painful temporomandibular disorder (TMD) and one of the following headache types: migraine, tension‐type headache (TTH), or headache attributed to TMD, corrected for the influence of bruxism. A retrospective study was conducted at an orofacial pain and dysfunction (OPD) clinic. Inclusion criteria were painful TMD, with migraine, TTH, and/or headache attributed to TMD. Linear regressions were performed to assess the influence of psychosocial variables on pain intensity and on pain‐related disability, stratified per headache type. The regression models were corrected for bruxism and the presence of multiple headache types. A total of 323 patients (61% female; mean age 42.9, SD 14.4 years) were included. Headache pain intensity only had significant associations in TMD‐pain patients with headache attributed to TMD, and anxiety showed the strongest relation (β = 0.353) with pain intensity. Pain‐related disability was most strongly associated with depression in TMD‐pain patients with TTH (β = 0.444), and with somatization in patients with headache attributed to TMD (β = 0.399). In conclusion, the influence of psychosocial factors on headache pain intensity and pain‐related disability depends on the headache type presenting.
The use of prostaglandin applied in Bai Hui Acupoint on mare reproductive efficiency
Authors: Janini Ludimila Cardoso Zoccal , Silva Maria Isabela Azeredo , Rizzoto Guilherme , Fonseca‐Alves Carlos Eduardo , de Camillo Beatriz Lippe , Aristizábal Viviana Helena Vallejo , Negreiros Natalia Felix , Corona Luiz Fernando Cintra , Hara Eduardo , Mendonça Victor Hugo , Mendonça Heitor Vinicius , Cipriano Rafael Silva 
Published: February 2023

SummaryProstaglandin F2α (PGF2α) is one of the most frequently used drugs for pharmacologic manipulation of the oestrous cycle in mares. Among its roles, PGF2α induces luteolysis, leading to an early oestrus return, which reduces the dioestrous phase and the inter‐ovulatory intervals. Interestingly, mares are more sensitive to PGF2α than other domestic species, hence lower doses are used; even so, the side effects are still adverse and inconvenient for animals and breeders. Recent studies of acupuncture, a traditional Chinese medicine technique, have been performed as an alternative to decrease the PGF2α dose for mares. The efficacy described of applying lower doses of PGF2α at specific acupoints is similar to that obtained with the regular dose. Therefore, the objective of this study was to analyse the reproductive performance and characteristics of oestrus in embryo recipient and donor mares using different doses at the Bai Hui—an acupoint located on the dorsal midline, also known as ‘the point of one hundred meetings’, as its region of effect encompasses many nerve trunks, nerve endings and vascular networks—a useful veterinary acupuncture treatment for ovarian disorders. For this study, 76 Quarter Horse mares were randomly assigned to three experimental groups: Control (CTR)—Intramuscular (IM) administration of 5 mg PGF2α; Bai Hui 5 mg (BH5)—application of 5 mg at the Bai Hui acupoint; and Bai Hui 2.5 mg (BH2.5)—application of 2.5 mg at the Bai Hui acupoint. In the results, there were no differences regarding uterine oedema, pregnancy rate or body condition score among the groups. However, oestrous expression was lower (p < 0.001) in both BH groups compared with CTR. Lastly, the interval between application and ovulation was shorter in BH5 compared with CTR (p = 0.042). The results indicate BH5 and BH2.5 as viable alternatives to the IM administration.
Ex vivo pilot study evaluating needle tenoscopy of the digital flexor tendon sheath and its suitability to assist palmar annular ligament transection
Authors: Barnes Harriet K. S. , Sinovich Matthew , Baldwin Christopher M. , Gillen Alexandra , Stack John David 
Published: February 2023

SummaryBackgroundThe digital flexor tendon sheath (DFTS) is a common site of pathology in the UK equine population, often necessitating tenoscopic exploration. Common intrathecal pathologies may lead to fetlock canal constriction. The palmar/plantar annular ligament (PAL) is often surgically transected to relieve constriction or to facilitate surgical access and instrumentation.ObjectivesThe objectives of this study were (1) to establish whether diagnostic quality needle tenoscopy can be achieved in the proximal DFTS in cadaver limbs; (2) to determine if needle tenoscopy can be used to safely guide PAL transection; and (3) to evaluate iatrogenic damage when undertaking needle tenoscopy and PAL transection.Study designEx vivo experimental.MethodsSix cadaveric limbs were used and needle tenoscopy of the DFTS was performed via biaxial approach at the base of the sesamoids. Access to and diagnostic assessment of the proximal DFTS, as well as the completeness of needle tenoscopically guided transection of the PAL was recorded. Limbs were dissected and examined for iatrogenic damage and completion of PAL transection.ResultsPositioning of the cannula/obturator unit was achieved on the first attempt 11/12 times. Laterally 16/24 and medially 18/24 proximal DFTS channels were accessed. Images were of diagnostic quality in 12/24 and 11/24 channels following lateral and medial approach, respectively. The PAL was completely transected in 4/6 limbs with partial transection in 1/6 limbs. The superficial digital flexor tendon (SDFT) was longitudinally lacerated instead of the PAL in one limb, with other iatrogenic damage limited to mild fibrillation to the intersesamoidean ligament.Main limitationsEx vivo and sample size.ConclusionsThe findings in this pilot study suggest that needle tenoscopically guided PAL transection in the live horse is not recommended currently. While diagnostic needle tenoscopy offered partial assessment of most of the proximal DFTS, further refinement is necessary before needle tenoscopy could be considered a viable alternative to traditional tenoscopy.
Teaching food literacy in Queensland secondary schools: The influence of curriculum
Authors: McManus Sarah , Pendergast Donna , Kanasa Harry 
Published: February 2023

AbstractFood literacy education is essential for acquiring the skills and knowledge required to support healthy food interactions. However, there are multiple constraints impacting curriculum enactment in schools. This study explores these constraints in Queensland (Australia), giving voice to Home Economics teacher respondents. A mixed methods survey was conducted (n = 117) in February–March 2021. Eighty percent of respondents advocated for current curriculum change to support food literacy education, including incorporating more explicit practical food education, the transition of nutrition into home economics subjects, and the insertion of food literacy‐focused terminology within the curriculum.
Scarce fashion products consumption in the C2C second‐hand trading platform
Authors: Park Hyun Hee 
Published: February 2023

AbstractUtilizing self‐licensing theory, this study aimed to identify the psychological mechanism of the consumption of scarce fashion products on customer‐to‐customer (C2C) second‐hand online trading platforms. This research used a 2 (scarcity level: high vs. low) × 2 (consumers' environmental consciousness: high vs. low) mixed factorial design. Consumers with low environmental consciousness mediated ease of justification when exposed to scarce information, thereby increasing their impulse purchase intentions, while consumers with high environmental consciousness did not. The C2C second‐hand trading platform can contribute to the interests of both sellers and buyers as an exciting place to purchase scarce goods and consume eco‐friendly fashion products.
The expression of cyclic GMP–AMP synthase in human apical periodontitis: A laboratory investigation
Authors: Yang Fan , Liu Liu , Wang Liu , Ji Xiao , Zeng Yanglin , Du Jing , Zhang Lan , Huang Dingming 
Published: February 2023

AbstractAimAs a key DNA sensor, cyclic GMP–AMP synthase (cGAS) has emerged as a major mediator of innate immunity and inflammation. Human apical periodontitis has yet to be studied for the presence of cGAS. This investigation was conducted to determine if cGAS is involved in the pathological process of human apical periodontitis.MethodologySixty four human periapical lesions, comprising 20 periapical granulomas and 44 radicular cysts, were employed in this investigation. Healthy gingiva (n = 6), dental pulp (n = 3), and apical papilla (n = 3) were used as control samples. The expression of cGAS in the periapical tissues was discovered using immunohistochemical staining. mRNA‐Sequencing and qRT‐PCR were utilized to determine the differentially expressed genes (DEGs) associated with DNA‐sensing signalling in periapical lesions compared to the healthy control. Immunofluorescence labelling was used to identify the co‐expression of cGAS, interleukin‐1β, and interleukin‐18.ResultsA significantly greater expression level of cGAS was discovered in the periapical lesions, with no significant difference between radicular cysts and periapical granulomas. mRNA‐Sequencing analysis and qRT‐PCR identified differentially expressed mRNA, such as cGAS and its downstream DEGs, between periapical lesions and healthy control tissues. Immunofluorescence labelling further revealed that cGAS, interleukin‐1, and interleukin‐18 were co‐localized.ConclusionsThese observations imply that along with the synthesis of interleukin‐1 and interleukin‐18, cGAS may be involved in the aetiology of apical periodontitis.
Brazing SiCf/SiC and TZM alloy with AuPdTiCrCu dual active element filler metal
Authors: Feng Hongliang , Chen Bo , Ren Xinyu , Ren Haishui , Li Wenwen , Pei Chong , Zhang Yuanwei , Li Sisi , Zou Wenjiang , Xiong Huaping , Cheng Yaoyong 
Published: February 2023

AbstractFor the joining of SiCf/SiC and TZM alloy, an AuPdTiCrCu filler metal with dual active element of Ti and Cr was synthesized. The brazing process was carried out under the condition of 1200°C for 10 min. It was shown that fine Cr‐based solid solutions were dispersed in the filler metal. When brazing, the element Cr and Ti moved toward the base metal and reacted with them to form into Mo‐Cr‐Si and Mo‐Cr‐Ti‐Si compounds. These two active elements could promote the metallurgical reaction of the joint. Meanwhile, it was found that some Pd‐Si compounds, fragments of (Au, Cu)ss and soft Au‐Ti phases formed in the middle regions of the joint. (Au, Cu)ss and Au‐Ti phases distributed around the Pd‐Si compounds. In addition, the joining mechanism was discussed and the mechanical properties of the joints were tested. The results showed that the average four point flexural strength of the joints reached 88.5 MPa at room temperature and 46.8 MPa at 500°C. The fracture characters of the joints were discussed in the last.
ppb‐Level ethanol gas sensor of porous anodic aluminum oxide at room temperature
Authors: Park Ji Young , Yi Jae‐Ho , Choa Yong‐Ho 
Published: February 2023

AbstractExcessive ethanol in breath can be an indicator of alcoholism and a biomarker of liver disease. Herein, we present a novel porous aluminum anodic oxide (AAO)‐based chemi‐capacitive sensor that can detect ppb‐levels of ethanol gas at room temperature. The oxalic acid‐based porous AAO is an amorphous material contaminated with Al(OH)3 and C2O42− ions (anion‐contamination), which react with adsorbed ethanol gas. The optimal resonance frequency of ethanol was determined to be 500 Hz, and the response to 200 ppm ethanol at this frequency was 1.56%. Especially, the limit of detection of ppb‐level (16.49 ppb) was obtained. The detection range, reliability, and selectivity of the sensor, as well as its surface properties were comprehensively investigated. The proposed sensor is promising for the detection of liver disease as well as for commercial breath ethanol analyzers.
Ableism, racism, and the quality of life of Black, Indigenous, people of colour with intellectual and developmental disabilities
Authors: Friedman Carli 
Published: February 2023

AbstractBackgroundResearch indicates Black, Indigenous, people of colour (BIPOC) with intellectual and developmental disabilities face disparities in quality of life outcomes. This study's aim was to examine how ableism and racism impacted the quality of life of BIPOC with intellectual and developmental disabilities.MethodsUsing a multilevel linear regression, we analysed secondary quality of life outcome data from Personal Outcome Measures® interviews with 1393 BIPOC with intellectual and developmental disabilities and implicit ableism and racism data from the 128 regions of the United States in which they lived (discrimination data came from 7.4 million people).ResultsWhen BIPOC with intellectual and developmental disabilities lived in regions of the United States which were more ableist and racist, they had a lower quality of life, regardless of their demographics.ConclusionAbleism and racism are a direct threat to BIPOC with intellectual and developmental disabilities' health, wellbeing, and overall quality of life.
Using Simulated Retests to Estimate the Reliability of Diagnostic Assessment Systems
Authors: Thompson W. Jake , Nash Brooke , Clark Amy K. , Hoover Jeffrey C. 
Published: February 2023

AbstractAs diagnostic classification models become more widely used in large‐scale operational assessments, we must give consideration to the methods for estimating and reporting reliability. Researchers must explore alternatives to traditional reliability methods that are consistent with the design, scoring, and reporting levels of diagnostic assessment systems. In this article, we describe and evaluate a method for simulating retests to summarize reliability evidence at multiple reporting levels. We evaluate how the performance of reliability estimates from simulated retests compares to other measures of classification consistency and accuracy for diagnostic assessments that have previously been described in the literature, but which limit the level at which reliability can be reported. Overall, the findings show that reliability estimates from simulated retests are an accurate measure of reliability and are consistent with other measures of reliability for diagnostic assessments. We then apply this method to real data from the Examination for the Certificate of Proficiency in English to demonstrate the method in practice and compare reliability estimates from observed data. Finally, we discuss implications for the field and possible next directions.
The skin mucosal barrier of lumpfish (Cyclopterus lumpus L.) is weakened by exposure to potential aquaculture production‐related stressors
Authors: Ytteborg Elisabeth , Lazado Carlo C. , Noble Chris , Hansen Roy Inge , Johansen Lill‐Heidi 
Published: February 2023

AbstractVarious cleaner fish species, such as the lumpfish (Cyclopterus lumpus L.), are used in the sea cage production of Atlantic salmon (Salmo salar L.) as a control measure against the ectoparasitic salmon louse (Lepeophtheirus salmonis). Nonetheless, during severe lice infestation, alternative treatments are required to control parasitic burden. The aim of this study was to gain insight into how lumpfish skin responds to different chemicals used to treat parasites. The authors collected skin from lumpfish from both research facilities (tank‐reared fish) and commercial production (cage‐reared fish) and used operational welfare indicators, in vitro models, histology and transcriptomics to study how the skin responded to two anti‐parasitic oxidative chemicals, hydrogen peroxide (H2O2) and peracetic acid. Lumpfish sampled from the farm were classified as clinically healthy or weak based on their morbidity status, and fish from each category were used to gain insight into how the therapeutics affect the skin barrier. Differences between healthy and weakened (moribund) fish, and between treated fish from each of the two groups, were observed. Histological examination showed an overall reduced skin quality in fish characterized as moribund, including different grades of exposed bony plates. In vitro oxidant‐treated lumpfish skin had reduced the migration capacity of keratocytes, a weakened epidermal barrier, and altered gene transcription, changes that are known predisposing factors to secondary infections. Skin from non‐treated, healthy fish sampled from commercial farms exhibited similar features and attributes to oxidant‐exposed tank‐reared fish from a research facility, suggesting that apparently healthy cage‐held lumpfish exhibited stress responses in the epidermal barrier. The results of the study outline the risks and consequences lumpfish can face if accidentally subjected to potential anti‐parasitic oxidant treatments aimed at Atlantic salmon. It also strengthens the evidence behind the requirement that lumpfish should be removed from the cages before being potentially exposed to this type of treatment and outlines the potential risks of differing husbandry practices upon lumpfish health, welfare and resilience.
Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis
Authors: Xu Weimin , Ou Weijun , Feng Yuan , Xu Qingru , Yang Yili , Cui Long , Du Peng 
Published: February 2023

AbstractBackgroundGenetic compensation response (GCR) is a mechanism that maintains the robustness of functional genes, which has been recently identified. Whether GCR exists in tumors and its effects on tumor progression remains unknown.MethodsWhole exome sequencing was performed to identify premature termination codon (PTC) gene mutations in colorectal cancer (CRC) tissues. RNA sequencing, Cancer Cell Line Encyclopedia database analysis, and high‐throughput output of homologous genes using the Ensemble genome database were performed to further identify homologous genes of target PTC gene mutations.ResultsSerine and arginine‐rich splicing factor 3 (SRSF3) increased the invasion ability in CRC cells and could be the target gene of up‐frameshift 3A (UPF3A). The deletion of the 660th base A in the coding sequence region of SRSF6 caused a frameshift mutation of serine at position 220 (s220fs), which contributed to a PTC UAA termination of translation in HCT116 cells. We further found that SRSF3 was the only homologue of SRSF6 with a frameshift mutation. The transfection of s220fs of SRSF6 into HCT116 cells led to upregulation of its corresponding oncogenic homologue gene SRSF3 expression to promote CRC metastasis. SRSF3 was highly expressed in CRC liver metastases and was positively correlated with UPF3A expression and contributed to poor prognosis.ConclusionGCR may exist in CRC and exert effects on the progression of CRC. Targeted inhibition of UPF3A could reduce the GCR effects and suppress the expression of oncogenic homologue genes corresponding to PTC mutations, indicating a novel therapeutic strategy for treatment of CRC metastasis.
30‐day readmission rates among upper gastrointestinal bleeds: A systematic review and meta‐analysis
Authors: Dunne Cody L , Kaur Sandeep , Delacruz Bronwyn , Bresee Lauren C 
Published: February 2023

AbstractBackground and AimUpper gastrointestinal bleeding (UGIB) is a common emergency, with high rates of hospitalization and in‐patient mortality compared to other gastrointestinal diseases. Despite readmission rates being a common quality metric, little data are available for UGIBs. This study aimed to determine readmission rates for patients discharged following an UGIB.MethodsAdhering to PRISMA guidelines, MEDLINE, Embase, CENTRAL, and Web of Science were searched to October 16, 2021. Randomized and non‐randomized studies that reported hospital readmission for patients following an UGIB were included. Abstract screening, data extraction, and quality assessment were conducted in duplicate. A random‐effects meta‐analysis was performed, with statistical heterogeneity measured using I2. The GRADE framework, with a modified Downs and Black tool, was used to determine certainty of evidence.ResultsSeventy studies were included of 1847 screened abstracted, with moderate interrater reliability. Within these studies, 4 292 714 patients were analyzed with a mean age of 66.6 years, and 54.7% male. UGIB had a 30‐day all‐cause readmission rate of 17.4% (95% confidence interval [CI] 16.7–18.2%), stratification revealed a higher rate for variceal UGIB [19.6% (95% CI 17.6–21.5%)] than non‐variceal [16.8% (95% CI 16.0–17.5%)]. Only one third were readmitted due to recurrent UGIB (4.8% [95% CI 3.1–6.4%]). UGIB due to peptic ulcer bleeding had the lowest 30‐day readmission rate [6.9% (95% CI 3.8–10.0%)]. Certainty of evidence was low or very low for all outcomes.ConclusionsAlmost one in five patients discharged after an UGIB are readmitted within 30 days. These data should prompt clinicians to reflect on their own practice to identify areas of strength or improvement.