bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy
Authors: Su Yuanzhen , Jin Guanyu , Zhou Huicong , Yang Zhaofan , Wang Lanqing , Mei Zi , Jin Qionghua , Lv Shixian , Chen Xuesi 
Published: March 2023

Abstract
The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.
Cylindrical vector beams demultiplexing communication based on a vectorial diffractive optical element
Authors: Cao Mengwei , Xie Zhenwei , Zhong Yanan , Lei Ting , Zhang Wanlong , Liu Shutian , Yuan Xiaocong 
Published: March 2023

Abstract
Cylindrical vector beams with polarization singularities, transmission stability and turbulence resilient, are orthogonally structured light beams providing new degrees of freedom for multiplexing optical communications. The demultiplexing of the CVBs with high efficiency and low crosstalk is of vital importance for the practical applications. Here, we propose a lens-less CVB sorting approach with a set of dielectric metasurface devices. The metasurface is composed of elliptical silicon nanopillars, which are capable of vector field steering. By performing mode transformations on both left-handed and right-handed polarization components of the CVBs, cylindrical vector beams can be demultiplexed with high efficiency and reduced crosstalk. Furthermore, by adjusting the phase response of the vectorial diffractive element into a set of Pancharatnam–Berry (PB) phase planes, we experimentally demonstrate 11 CVBs sorting with a set of P–B phase liquid crystal devices. The proposed device may benefit the CVB-based mode multiplexing communications in future.
Heidegger’s Nietzsche, and the Finite Repetition of Difference
Authors: Hughes Emily 
Published: March 2023

Abstract
In this review essay, I take up a critical analysis of three recently published monographs in Heidegger-Nietzsche scholarship. Whilst their projects are diverse, I suggest that Winkler, Parra and Armitage are each fundamentally concerned with the critique of the Cartesian subject in Heidegger’s interpretation of Nietzsche and attempt to varying extents to ground this problematization of subjectivity in the phenomenon of time. Nevertheless, whilst each emphasises the importance of time in understanding both Heidegger’s and Nietzsche’s critique of the subject, it is surprising that they either underplay or misappropriate the significance of eternal recurrence, the temporal phenomenon which Heidegger defines as Nietzsche’s “thought of thoughts.” After engaging each account, my aim is to then consider how they might be critically re-framed in light of Heidegger’s interpretation of eternal recurrence which, I suggest, is fundamental to understanding Heidegger’s engagement with Nietzsche, as well as his own philosophical project more broadly.
Being Truly Wrong: Enlightened Nihilism or Unbound Naturalism?
Authors: Gamez Patrick 
Published: March 2023

AbstractI present an account of nihilism, following Foucault and Nietzsche, as a sort of colonization of our thinking by a religious form of normativity, grounded in our submission to truth as correspondence, in the idea that the facts themselves could be binding upon us. I then present Brassier’s radicalization of nihilism and showed how it remains subservient to this religious ideal of truth. I argue, further, that far than showing how a commitment to Enlightenment reason and science demands a cold metaphysics of death, in dismissing the irreducibly plural ways in which what is determines thought, Brassier’s attempt to secure a fit between thought and disenchanted world suggests that the view is an expression of the unliveable condition of nihilism, rather than its proof. Finally, I present a form of naturalism that makes legitimate claim to the legacy of Enlightenment, drawing from French historical epistemology, and dispenses with the problems animating Brassier’s nihilism by radically transforming the concept of truth and how we relate to it.
Prometheus’ Fluch – der früheisenzeitliche Töpferofen von Groß Kienitz (Brandenburg) in der paneuropäischen Perspektive
Authors: Dittrich Annett , Geßner Kerstin 
Published: March 2023

Zusammenfassung
Der 2017 ausgegrabene früheisenzeitliche Keramikbrennofen von Groß Kienitz (Brandenburg) wies in situ erhaltene Reste von Brenngut auf. Die Funde liegen zum einen als kollabierte, jedoch nahezu vollständige Fehlbrände, zum anderen als zahlreiche als Brennhilfen und Füllmaterial verwendete Gefäßscherben vor. Da sich das Formengut des geschlossenen Fundes sowohl der ausgehenden Bronzezeit als auch der frühen Eisenzeit mit ausgeprägten Elementen der lokalen Göritzer Gruppe zuordnen lässt, ist die strikte Epochentrennung hier einmal mehr infrage gestellt. Bisher ohne Parallelen bleiben bauliche Details des Lehmkuppelofens wie der portable Schlotverschluss aus einem sekundär verwendeten Keramikgefäß. Darüber deutet sich eine experimentelle Phase an, die mit neuen Anforderungen, etwa an die Erzeugung dunkler, reduzierend gebrannter Gefäßoberflächen, einherging. Zugleich sind der Ofenbau im Licht eines neuen handwerklichen Selbstverständnisses und die antike Feuerverwendung vor einem mytho-praktischen Hintergrund zu sehen. Quellen wie etwa der Homer zugeschriebene „Ofensegen“ betonen, dass der Brandvorgang nach dem Verschluss des Ofens (Reduktionsphase) ohne die Möglichkeit einer weiteren Beeinflussung stattfindet. In der antiken Vorstellung konnte diese kritische Phase ohne den erforderlichen übernatürlichen Beistand in Fehlbränden und in der Zerstörung des Ofens münden.
Sterically crowded di-indazolyl-pyridines: Iron(II) complexation studies
Authors: Omar Suhad , Irran Elisabeth , Wiedemann Dennis , Baabe Dirk , Grohmann Andreas 
Published: March 2023

Abstract
4-(2,6-Di(2H-indazol-2-yl)pyridin-4-yl)benzoic acid (1) and 10-(2,6-di(1H-pyrazol-1-yl)pyridin-4-yl)anthracene-9-carboxylic acid (2) were required for adsorption studies on Ag(111), with a view to subsequent iron(II) complexation and formation of well-ordered spin-responsive self-assembled monolayers. While the generation of these compounds has remained elusive, several intermediates and by-products were obtained, potentially useful as dipyrazolylpyridine-related derivatives and for metal ion coordination. 3,5-Dichloro-2,6-diindazolylpyridine-4-amine, which forms as a mixture of regioisomers, was synthesised, the mixture separated, and the components characterised (3,5-dichloro-2,6-di(2H-indazol-2-yl)pyridin-4-amine; 3,5-dichloro-2-(1H-indazol-1-yl)-6-(2H-indazol-2-yl)pyridin-4-amine; 3,5-dichloro-2,6-di(1H-indazol-1-yl)pyridin-4-amine). Their iron(II) complexes have been prepared and fully characterised, including single crystal X-ray structure determination. The complexes are instructive examples of the influence of ligand design (“steric jamming”) on the spin-crossover (SCO) activity of FeII centres. Bulky substitution, which entails twisted ligand conformation, increases intramolecular crowding. This prevents contraction of the metal coordination sphere, which would be a prerequisite for thermally inducible SCO. Mössbauer spectroscopy has revealed that the complexes remain predominantly high-spin (HS) between 20 and 200 K, and that a mixture of conformational HS isomers is present in the microcrystalline solid.
Principales rasgos gramaticales del español de Guatemala
Authors: Pato Enrique 
Published: March 2023

Abstract
This work offers an in-depth description of the main morphosyntactic (and lexical) features found in present Guatemalan Spanish, a lesser-known Central American variety. Text corpora and sociolinguistic surveys help us to provide an updated grammatical overview, which takes into account most categories: nouns and adjectives, pronouns, verbs, adverbs, prepositions and locutions, and it is illustrated with examples taken both from formal and informal settings. By comparing these features with previous grammatical descriptions, this study helps in identifying some common American features —such as the use of hasta and una mi amiga— as well as some specific patterns —such as the prominence of several suffixes and pronouns— in present-day Guatemalan Spanish, some of which remain to be incorporated in the Academy grammar.
Ballistic Exercise Versus Heavy Resistance Exercise Protocols: Which Resistance Priming Is More Effective for Improving Neuromuscular Performance on the Following Day?
Authors: Nishioka Takuya , Okada Junichi 
Published: March 2023

Abstract
Nishioka, T and Okada, J. Ballistic exercise versus heavy resistance exercise protocols: which resistance priming is more effective for improving neuromuscular performance on the following day? J Strength Cond Res 37(10): 1939–1946, 2023—This study aimed to determine whether ballistic exercise priming (BEP) or heavy resistance priming (HRP) is more effective for improving ballistic performance after 24 hours. Ten resistance-trained men performed BEP and HRP conditions 72–144 hours apart in a randomized and counterbalanced order. Jumping performance was assessed before and 24 hours after the BEP and HRP sessions using 0 and 40% one-repetition maximum (1RM) squat jump (SJ), 0 and 40% 1RM countermovement jump (CMJ), and drop jump (DJ) reactive strength index (RSI). Statistical significance was accepted at p ≤ 0.05. In the BEP condition, 0% 1RM CMJ height (+3.62%) as well as theoretical maximum velocity (+5.14%) and theoretical maximum power (+2.55%) obtained from CMJ 24 hours after the priming session were significantly greater than those at the baseline (p ≤ 0.05), but 0% 1RM SJ height and DJ RSI (p > 0.05) were not greater than those at the baseline. In the HRP condition, the jump performances were not improved (p > 0.05). The percentage change in 0% 1RM CMJ height in the BEP condition was significantly greater than that seen in the HRP condition (p = 0.015) but did not differ for 0% 1RM SJ height and DJ RSI (p > 0.05). These results suggest that the BEP is more effective than HRP in improving CMJ performance after 24 hours. Therefore, practitioners should consider prescribing resistance priming using low-load ballistic exercises rather than high-load traditional exercises when planning to enhance athlete performance on the following day.
Behavioral and Functional Brain Activity Alterations Induced by TMS Coils with Different Spatial Distributions
Authors: Pell Gaby S. , Roth Yiftach , Shachar Hamutal , Isserles Moshe , Barnea-Ygael Noam , Zangen Abraham 
Published: March 2023

AbstractPrevious investigation of cognitive processes using transcranial magnetic stimulation (TMS) have explored the response to different stimulation parameters such as frequency and coil location. In this study, we attempt to add another parameter by exploiting the spatial profiles of TMS coils to infer regional information concerning reward-related behavior. We used different TMS coils to modulate activity in the prefrontal cortex (PFC) and examined resulting changes in behavior and associated brain activity. More specifically, we used the Figure-8 coil to stimulate a portion of the dorsolateral PFC (DLPFC) and the H-Coil to stimulate a larger volume within the lateral PFC (LPFC). Healthy human volunteers completed behavioral questionnaires (n = 29) or performed a reward-related decision-making functional MRI (fMRI) task (n = 21) immediately before and after acute high-frequency stimulation (10 Hz) with either a Figure-8 coil, H-Coil, or a sham coil. Stimulation was found to induce behavioral changes as well as changes in brain activation in key nodes of the reward network. Right LPFC, but not right DLPFC or sham, stimulation was found to induce changes in both behavioral scores and brain activation in key nodes of the reward system. In conclusion, this study supports the role of the right LPFC in reward-related behavior and suggest that the pathways through which the observed effects were generated are located outside the area of the DLPFC that is traditionally targeted with TMS. These results demonstrate the use of TMS coils with different spatial profiles as an informative tool to investigate anatomic and functional correlates of behavior.
Random Tactile Noise Stimulation Reveals Beta-Rhythmic Impulse Response Function of the Somatosensory System
Authors: Chota Samson , VanRullen Rufin , Gulbinaite Rasa 
Published: March 2023

Both passive tactile stimulation and motor actions result in dynamic changes in beta band (15–30 Hz Hz) oscillations over somatosensory cortex. Similar to alpha band (8–12 Hz) power decrease in the visual system, beta band power also decreases following stimulation of the somatosensory system. This relative suppression of α and β oscillations is generally interpreted as an increase in cortical excitability. Here, next to traditional single-pulse stimuli, we used a random intensity continuous right index finger tactile stimulation (white noise), which enabled us to uncover an impulse response function of the somatosensory system. Contrary to previous findings, we demonstrate a burst-like initial increase rather than decrease of beta activity following white noise stimulation (human participants,N= 18, 8 female). These β bursts, on average, lasted for 3 cycles, and their frequency was correlated with resonant frequency of somatosensory cortex, as measured by a multifrequency steady-state somatosensory evoked potential paradigm. Furthermore, beta band bursts shared spectro-temporal characteristics with evoked and resting-state β oscillations. Together, our findings not only reveal a novel oscillatory signature of somatosensory processing that mimics the previously reported visual impulse response functions, but also point to a common oscillatory generator underlying spontaneous β bursts in the absence of tactile stimulation and phase-locked β bursts following stimulation, the frequency of which is determined by the resonance properties of the somatosensory system.SIGNIFICANCE STATEMENTThe investigation of the transient nature of oscillations has gained great popularity in recent years. The findings of bursting activity, rather than sustained oscillations in the beta band, have provided important insights into its role in movement planning, working memory, inhibition, and reactivation of neural ensembles. In this study, we show that also in response to tactile stimulation the somatosensory system responds with ∼3 cycle oscillatory beta band bursts, whose spectro-temporal characteristics are shared with evoked and resting-state beta band oscillatory signatures of the somatosensory system. As similar bursts have been observed in the visual domain, these oscillatory signatures might reflect an important supramodal mechanism in sensory processing.
Gambaran Karakteristik dan Penyakit Komorbid pada Pasien Konfirmasi Covid-19 di RSUD Ulin Banjarmasin Tahun 2020
Authors: Cibro Agnes Angelina Laila , Skripsiana Nika Sterina , Muthmainah Noor , Heriyani Farida , Zaitun Nani 
Published: March 2023

Abstract: Coronavirus Disease 2019 (COVID-19) is an irresistible sickness brought about by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The spread of COVID-19 has turned into a worldwide wellbeing danger until May 13, 2020, there were 4 million affirmed instances of COVID-19 with 287,399 passings announced in excess of 210 impacted nations around the world. This study expects to depict the attributes old enough, orientation, instruction and occupation and comorbid infections in affirmed COVID-19 patients at Ulin Hospital Banjarmasin. This study is a descriptive study involving auxiliary information as understanding clinical records at the Ulin Regional General Hospital Banjarmasin period March-December 2020. Data analysis using the method sampling purposive. The number of samples is 219 people. The results showed that the dominant patient characteristics were age 50 years (60.7%), male gender (50.7%), high school education (51.4%) and self-employed (30.1%) . Meanwhile, the predominant comorbid disease was diabetes mellitus (21.6%) Keywords: COVID-19, characteristics, comorbid disease, confirmed patient. Abstrak: Coronavirus Disease 2019 (COVID-19) adalah penyakit menular yang disebabkan oleh Sindrom Pernafasan Akut Parah Coronavirus 2 (SARS-CoV-2). Penyebaran COVID-19 telah menjadi ancaman kesehatan di seluruh dunia hingga 13 Mei 2020, ada 4 juta kasus dikonfirmasi COVID-19 dengan 287.399 kasus kematian diumumkan di lebih dari 210 negara yang terkena dampak di seluruh dunia. Penelitian ini diharapkan dapat menggambarkan karakteristik berdasarkan umur, jenis kelamin, pendidikan dan pekerjaan serta penyakit komorbid pada pasien konfirmasi COVID-19 di RSUD Ulin Banjarmasin. Penelitian ini merupakan penelitian deskriptif dengan data sekumder rekam medis pada pasien konfirmasi COVID-19 di RSUD Ulin Banjarmasin periode Maret-Desember 2020. Analisis data menggunakan metode sampling purposive. Jumlah sampel sebanyak 219 orang. Hasil penelitian menunjukkan bahwa karakteristik pasien yang dominan adalah usia 50 tahun (60,7%), jenis kelamin laki-laki (50,7%), pendidikan SLTA (51,4%) dan wiraswasta (30,1%). Sedangkan penyakit penyerta yang dominan adalah diabetes mellitus (21,6%) Kata-kata kunci: COVID-19, karakteristik, penyakit komorbid, pasien konfirmasi
Gambaran Pemberian Beta Bloker pada Pasien Gagal Jantung di RSUD Ulin Banjarmasin
Authors: Radhiyyah Hafizhah Dzikra , Adiputro Dwi Laksono , Biworo Agung , Rudiansyah Mohammad , Illiandri Oski 
Published: March 2023

Abstract: Heart failure is an abnormality of the structure or function of the heart that causes the failure of the heart to distribute oxygen throughout the body. Beta-blockers have been shown to help prevent symptoms of heart failure, improve left ventricular remodeling, reduce the risk of hospitalization and premature death, but their use is still often underutilized and/or prescribed below the recommended dose. This study aims to determine the overview of beta-blocker administration in heart failure patients at outpatient installation RSUD Ulin Banjarmasin for February-July 2020. This research method is descriptive retrospective with data collection through patient medical records. The sampling technique is total sampling. The sample amounted to 165 patients. The results showed that there were 117 patients (70.9%) who received beta-blocker therapy with the sex was male in 90 (76.9%) patients and adult age (19-59 years) there were 81 (69.2%) patients. In this study, the type of beta-blocker given was from the selective beta-blocker group, namely bisoprolol (100%). The bisoprolol dosage used by outpatient varied, 1.25 mg (15.3%), 2.5 mg (43.5%), 5 mg (0.8%), 10 mg (2.5%), while the rest unknown (37.6%). Keywoards: heart failure, outpatients, beta-blocker Abstrak: Gagal jantung adalah abnormalitas dari struktur atau fungsi jantung yang menyebabkan kegagalan dari jantung untuk mendistribusikan oksigen ke seluruh tubuh. Obat golongan beta bloker terbukti membantu mencegah gejala gagal jantung, memperbaiki remodeling ventrikel kiri, menurunkan resiko rawat inap, dan kematian dini namun penggunaanya masih sering kurang dimanfaatkan dan/atau diresepkan di bawah dosis yang dianjurkan. Penelitian ini bertujuan untuk mengetahui gambaran pemberian beta bloker pada pasien gagal jantung yang dirawat jalan di RSUD Ulin Banjarmasin periode Februari – Juli 2020. Metode penelitian ini adalah descriptive retrospective dengan pengambilan data melalui rekam medik pasien. Teknik pengambilan sampel adalah total sampling. Sampel berjumlah 165 pasien. Hasil penelitian menunjukkan terdapat 117 pasien (70,9%) yang mendapatkan terapi beta bloker dengan jenis kelamin pria 90 (76,9%) pasien dan usia dewasa (19-59 tahun) ada 81 (69,2%) pasien. Pada penelitian ini didapatkan jenis beta bloker yang diberikan dari golongan beta bloker selektif yakni bisoprolol (100%). Dosis bisoprolol yang digunakan pasien rawat jalan bervariasi, dosis 1,25 mg (15,3%), 2,5 mg (43,5%), 5 mg (0,8%), 10 mg (2,5%), sedangkan sisanya tidak diketahui (37,6%). Kata-kata Kunci: gagal jantung, rawat jalan, beta bloker
Efektivitas Ekstrak Etanol Akar Bajakah Merah (Spatholobus littoralis hassk) sebagai Antimalaria secara In Vitro terhadap Plasmodium falciparum
Authors: Anisa Sinta , Wydiamala Erida , Hayatie Lisda 
Published: March 2023

Abstract: Malaria is also called vector born disease because it is transmitted through vectors. The potential vector of this disease is the Anopheles sp. This study aimed to test the effectiveness of the ethanol extract of the red bajakah root (Spatholobus littoralis hassk) as an antimalarial in vitro against Plasmodium falciparum. This research is an experimental study with Posttest Only with Control Group Design and consists of 6 treatment groups: 5 extract concentrations, namely concentrations of 0,391 μg/ml, 0,781 μg/ml, 1,562 μg/ml, 3,125 μg/ml, 6,25 μg/ml and a solution DMSO as a negative control. The treatment was carried out with 3 replications. Based on the results of research and data processing, the ethanolic extract of the red bajakah root (Spatholobus littoralis hassk) has effectiveness as an antimalarial against Plasmodium falciparum with an IC50 value of14,877 g/ml which is included in the active category. Keywords : antimalaria, red bajakah root, Plasmodium falciparum Abstrak: Malaria disebut juga vector born disease dikarenakan penularannya melalui vektor. Vektor potensial dari penyakit ini adalah nyamuk Anopheles sp. Penelitian ini bertujuan untuk menguji efektivitas ekstrak etanol akar bajakah merah (Spatholobus littoralis hassk) sebagai antimalaria secara in vitro terhadap Plasmodium falciparum. Penelitian ini merupakan studi eksperimental dengan Posttest Only with Control Group Design dan terdiri dari 6 kelompok perlakuan: 5 konsentrasi ekstrak yaitu konsentrasi 0,391 μg/ml, 0,781 μg/ml, 1,562 μg/ml, 3,125 μg/ml, 6,25 μg/ml dan larutan DMSO sebagai kontrol negatif. Perlakuan dilakukan dengan 3 kali replikasi. Berdasar hasil penelitian dan pengolahan data ekstrak etanol akar bajakah merah (Spatholobus littoralis hassk) memiliki efektivitas sebagai antimalaria terhadap Plasmodium falciparum dengan nilai IC50 sebesar 14.877 μg/ml yang termasuk dalam kategori aktif. Kata-kata kunci : antimalaria, akar bajakah merah, Plasmodium falciparum