bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous thromboembolism incidence and risk factors associated with immune checkpoint inhibitors among patients with advanced non-small cell lung cancer
Authors: Khorana Alok A , Palaia Jennell , Rosenblatt Lisa , Pisupati Radhika , Huang Ning , Nguyen Chi , Barron John , Gallagher Kerrin , Bond T Christopher 
Published: January 2023

BackgroundVenous thromboembolism (VTE) is a significant cause of morbidity and mortality in patients with lung cancer. Systemic therapies, such as chemotherapy (chemo), are associated with increased risk of VTE. Immune checkpoint inhibitors (ICIs) are a new standard of care for the treatment of lung cancer, but their association with VTE is not fully understood. We evaluated the incidence of VTE and risk factors for patients with advanced non-small cell lung cancer (aNSCLC) treated with first-line ICI-based, chemo-based, or ICI+chemo regimens.MethodsThis retrospective cohort study used HealthCore Integrated Research Environment - Oncology data, an integrated database of administrative claims, coupled with clinical data from a cancer-care quality program. Patients with first-line treatment of stage IV non-small cell lung cancer from July 2014 to August 2020 were grouped based on three treatment types: ICI-based, chemo-based, or ICI+chemo. Patients with VTE before initiation of systemic treatment were excluded. Newly diagnosed VTE events were identified via inpatient and outpatient diagnosis codes. Cox proportional hazards models were used to investigate the factors associated with VTE risk.ResultsAmong 2299 eligible patients (ICI-based, n=605; chemo-based, n=1092; ICI+chemo, n=602) with a median follow-up of 9.1 months, the VTE incidence rates (95% CI) per 100 person-years were 17.8 (95% CI 16.0 to 19.5) overall, 13.5 (95% CI 10.6 to 16.5) for ICI-based, 18.0 (95% CI 15.5 to 20.5) for chemo-based, and 22.4 (95% CI 20.2 to 24.5) for ICI+chemo. The 6-month cumulative incidence of VTE was 8.1% for ICI-based, 10.9% for chemo-based, and 12.8% for ICI+chemo. Pulmonary embolism was most common, accounting for 63% of the VTE events. After controlling for baseline patient characteristics, the risk of VTE was 26% lower for ICI-based regimens than for chemo-based regimens (HR 0.74, p=0.03). There was no meaningful difference in the risk between ICI+chemo and chemo-based regimens (HR 1.12, p=0.36). Previous radiation and severe obesity (body mass index ≥40) were associated with VTE.ConclusionsVTE incidence rate per 100 person-years was common across regimens in patients with aNSCLC, but numerically lower for patients receiving ICI-based regimens compared with those receiving chemo-based and ICI+chemo regimens. VTE is a common complication of lung cancer, and there is a continued need for awareness of VTE as a comorbidity in this population.
Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases
Authors: Liu Lu , Jouve Charlène , Henry Joséphine , Berrandou Takiy-Eddine , Hulot Jean-Sébastien , Georges Adrien , Bouatia-Naji Nabila 
Published: January 2023

Background:
Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells and evaluating their potential as cellular models in the context of complex diseases.

Methods:
Human induced pluripotent stem cell lines were differentiated using RepSox (R-SMCs) or PDGF-BB (platelet-derived growth factor-BB) and TGF-β (transforming growth factor beta; TP-SMCs), during a 24-day long protocol. RNA-Seq and assay for transposase accessible chromatin-Seq were performed at 6 time points of differentiation, and mass spectrometry was used to quantify proteins.

Results:

Both induced pluripotent stem cell differentiation protocols generated SMCs with positive expression of SMC markers. TP-SMCs exhibited greater proliferation capacity, migration and lower calcium release in response to contractile stimuli, compared with R-SMCs. Genes involved in the contractile function of arteries were highly expressed in R-SMCs compared with TP-SMCs or primary SMCs. R-SMCs and coronary artery transcriptomic profiles were highly similar, characterized by high expression of genes involved in blood pressure regulation and coronary artery disease. We identified
FOXF1
and
HAND1
as key drivers of RepSox specific program. Extracellular matrix content contained more proteins involved in wound repair in TP-SMCs and higher secretion of basal membrane constituents in R-SMCs. Open chromatin regions of R-SMCs and TP-SMCs were significantly enriched for variants associated with blood pressure and coronary artery disease.

Conclusions:
Both induced pluripotent stem cell–derived SMCs models present complementary cellular phenotypes of high relevance to SMC plasticity. These cellular models present high potential to study functional regulation at genetic risk loci of main arterial diseases.
Opposing Shifts of the Hadley Cell Edge and Eddy-Driven Jet Latitude in the Last Glacial Maximum: A Parameter Sweep Study Using a Dynamical Core GCM
Authors: Kim Seo-Yeon , Son Seok-Woo 
Published: January 2023

Abstract
A coherent poleward displacement of the Hadley cell (HC) edge and eddy-driven jet latitude has been well documented in the Southern Hemisphere (SH) under the present and future climate changes. However, a recent study showed that during the Last Glacial Maximum (LGM) winter, an equatorward shift of the HC edge but a poleward shift of the jet latitude are found in the SH. These opposing circulation changes are investigated in this study by conducting the parameter sweep experiments using a dynamical core general circulation model (GCM). By systematically varying the amplitude of tropical upper-tropospheric and polar surface cooling, mimicking the LGM-like climate state, an opposing shift of circulation is reproduced when polar cooling is much stronger than tropical cooling. This is due to the higher sensitivity of the jet-latitude change compared to the HC-edge change in response to polar cooling. Eddy cospectra analysis reveals that the poleward jet shift is dominated by fast waves as the baroclinic zone expands poleward with increasing polar surface cooling. Instead, the HC-edge change is largely attributed to the activity of slow waves and the axisymmetric circulation change. They lead to the HC edge being weakly influenced by extratropical baroclinicity, resulting in an equatorward shift of the HC edge under a global cooling–like condition. Similar circulation changes but with an opposite sign are also found in global warming–like experiments. This result suggests that a poleward HC shift together with an equatorward jet shift can occur even in a future climate if Arctic amplification is accelerated relative to tropical warming.
North Atlantic Oscillation–Associated Variation in Cloud Phase and Cloud Radiative Forcing over the Greenland Ice Sheet
Authors: Zhang Haotian , Zhao Chuanfeng , Xia Yan , Yang Yikun 
Published: January 2023

Abstract
The Greenland ice sheet (GrIS) has been losing mass at an accelerating rate in recent decades due to warming, and understanding the underlying mechanisms, such as the impacts of clouds, is essential. Using spaceborne data, this study investigates the spatial distribution of ice clouds and liquid-bearing clouds (LBCs) over the GrIS and their surface radiative forcing effects during summer daytime from 2006 to 2017, along with their characteristics during the North Atlantic Oscillation (NAO) events. Due to the perennial high-albedo surface, both ice and LBCs have a less important shortwave radiative cooling effect than in other environments. Based on the spatial variation pattern of clouds with the NAO index, the GrIS can be divided into three regions: the western, central, and eastern GrIS. During the positive NAO, the westerly wind strengthens in the western region, which causes the fraction of both ice clouds and LBCs to increase, and the cloud radiative effect at the surface increases by 2.07 W m−2; the temperature decreases in the central region, the fraction of ice clouds increases, the fraction of LBCs decreases, and the net radiative forcing is −2.05 W m−2; and sinking airflow is generated in the eastern region, both ice cloud and LBCs decrease, and the net cloud radiative effect at the surface is −1.34 W m−2. The spatial and temporal variations in clouds in different phases over the GrIS are closely related to the NAO, and the response of clouds to changes in the atmospheric circulation field during the NAO varies in different regions of the GrIS.

Significance Statement
This study investigates the associations between the North Atlantic Oscillation and the spatiotemporal variations in clouds, including both cloud fraction and cloud phases, and further examines the impacts of these changes on the surface radiation balance. The findings can help us improve our understanding of cloud variability and the corresponding influence on surface radiation over the GrIS, which are essential for better prediction of ice coverage over this region and for more efficient protection of ecosystems located there.
Energetics of Multiscale Interactions in the Agulhas Retroflection Current System
Authors: Li Mengmeng , Pang Chongguang , Yan Xiaomei , Zhang Linlin , Liu Zhiliang 
Published: January 2023

Abstract
Using the recently developed multiscale window transform and multiscale energy and vorticity analysis methods, this study diagnoses the climatological characteristics of the nonlinear mutual interactions among mesoscale eddies, low-frequency (seasonal to interannual) fluctuations, and the decadally modulating mean flow in the Agulhas Retroflection Current System (ARCS). It is found that mesoscale eddies are generated primarily in the retroflection region by mixed barotropic and baroclinic instabilities. The barotropic instability dominates the generation of eddy kinetic energy (EKE) here, contributing power roughly 10 times larger than the baroclinic one. These locally generated eddies are transported away. In the rings drift and meanders regions, the nonlocal transport serves as an important energy source for the eddy field, making a contribution comparable to that of the baroclinic instability for the EKE production. Contrarily, in the stable region, the EKE is generated mainly due to the baroclinic instability. In most of the ARCS area, the kinetic energy (KE) is further transferred inversely from mesoscale eddies to other lower-frequency motions. In particular, in the retroflection, rings drift, and stable regions, the inverse KE cascade plays a leading role in generating seasonal–interannual fluctuations, providing roughly 3–5 times as much power as the forward KE cascade from the mean flow and the advection effect. In the meanders region, however, the forward cascade contributes 4 times more KE to the low-frequency variabilities than the inverse one. All the results provide a model-based benchmark for future studies on physical processes and dynamics at different scales in the ARCS.
Predictive potential of albumin-alkaline phosphatase ratio for cerebrovascular accident in patients with antineutrophil cytoplasmic antibody–associated vasculitis
Authors: Ha Jang Woo , Pyo Jung Yoon , Ahn Sung Soo , Song Jason Jungsik , Park Yong-Beom , Lee Sang-Won 
Published: January 2023

Background This study investigated the predictive potential of the albumin-to-alkaline phosphatase ratio (AAPR) for cerebrovascular accident (CVA) occurrence in patients with antineutrophil cytoplasmic antibody–associated vasculitis. Methods This study included 239 AAV patients and reviewed their medical records retrospectively. AAPR was calculated using the following formula: AAPR = serum albumin (g/dL)/serum alkaline phosphatase (IU/L). CVA was defined only as cerebral infarction after AAV diagnosis in this study. In patients with CVA and those without CVA, the follow-up duration based on CVA was defined as the period from AAV diagnosis to CVA occurrence and to the last visit day, respectively. Results The median age of 239 AAV patients (130 microscopic polyangiitis, 64 granulomatosis with polyangiitis, and 45 eosinophilic granulomatosis with polyangiitis) was 59.0 years and 32.6% were men. The median serum albumin and alkaline phosphatase levels, and AAPR were 3.7 g/dL, 70.5 IU/L and 0.051, respectively. Nineteen patients had CVA during the median follow-up duration of 34.8 months. Using the receiver operator characteristic curve analysis, the optimal cut-off of AAPR for CVA occurrence was obtained as ≤ 0.035. AAV patients with AAPR ≤ 0.035 showed a significantly higher risk of CVA occurrence after AAV diagnosis than those with AAPR >0.035 (relative risk 5.000, p < 0.001). In the multivariable Cox analysis, only AAPR ≤ 0.035 was independently associated with CVA occurrence among AAV patients (hazard ratio 3.195, 95% confidence interval 1.014, 10.062). Conclusion This study demonstrated the predictive potential of AAPR calculated at AAV diagnosis for CVA occurrence after AAV diagnosis among AAV patients.
Current curricular trends after the COVID-19 pandemic: A national survey of psychiatry residency programs
Authors: Jin Jeff Wang , Smith Kacy , Helminiak Amanda , John Vineeth , Wu Hanjing Emily 
Published: January 2023

Objectives During the COVID-19 pandemic, many psychiatry residencies (academic, community, and hybrid programs) have adopted different learning modalities to preserve a high quality of educational training. There is minimal data on specific program adaptations, related change perspectives, and program type stratification. This study sought to examine trends in curriculum changes in accredited psychiatry residency programs in the United States. Methods Program directors of accredited general psychiatry programs in the United States were surveyed to assess both general program details and changes in educational content, delivery, and perspectives with regard to program curricula. Results A total of 63 program directors out of 264 eligible programs completed the questionnaire (23.9%). There was a significant shift to integrate virtual learning post-pandemic (98.5%) compared to pre-pandemic (3%). However, there was no association between these modality changes and program type ( p = 0.13). Furthermore, changes were noted with respect to didactic content (60%), decreased rotation sites (38%), and increased telemedicine exposure (84%) with no change of wellness days (67%) or protected time (97%). Again, the above changes had no association with program type. Use of virtual educational platforms was described as positive (59.7%) with 9 programs noting a future transition to a hybrid learning model for didactics and grand rounds. Conclusions The findings suggest that pandemic-related curriculum adaptations occurred in all different types of psychiatry residencies and suggest a national trend to continue virtual educational platforms with regard to psychiatry didactics. However, future investigation of effectiveness of virtual learning programs in psychiatry residencies is warranted.
Children with handwriting difficulties: Impact of cognitive strategy training for acquisition of accurate alphabet-letter-writing
Authors: Mathwin Kathryn , Chapparo Christine , Hinitt Joanne 
Published: January 2023

Introduction: An occupational therapy handwriting programme integrating cognitive strategy training with alphabet-letter-writing instruction was found more effective than in-class instruction alone for early writers. This study investigated the impact of cognitive strategy training for children struggling to correctly write alphabet-letters. Method: Participants were ten children in the first 2 years of formal schooling identified with challenges in alphabet-letter-writing. A nonconcurrent A1BA2 single system research design was used. The A Phases represented within-class handwriting instruction only and B Phase represented additional handwriting intervention which included cognitive strategy training. The Perceive, Recall, Plan and Perform (PRPP) System of Task Analysis (Stage 2) was the repeated outcome measure. Results: Results revealed all ten children demonstrated a similar pattern of change in cognitive strategy application which was concomitant with improvement and mastery in writing all 26-lowercase alphabet-letters from memory. Cognitive strategies which exhibited the greatest impact on acquiring and executing accurate alphabet-letter-writing skills were those related to planning, memory, attention and sensory perception. The least influential were those associated with generating and controlling motor actions. Conclusion: This study provides beginning support for including cognitive strategies training concurrently with alphabet-letter-writing instruction to assist children struggling to write alphabet-letters.
Comparative Study of ACL Reconstruction With Hamstring Versus Patellar Tendon Graft in Young Women: A Cohort Study From the New Zealand ACL Registry
Authors: Tiplady Anika , Love Hamish , Young Simon W. , Frampton Chris M. 
Published: January 2023

Background: Young female athletes are a specific population that is at high risk of primary anterior cruciate ligament (ACL) rupture and subsequent graft failure. Despite large numbers of ACL reconstructions being carried out in young women, there is limited analysis of outcomes in this group, leading to low levels of evidence for graft choice. Purpose: To assess the effect of graft choice on ACL reconstruction failure rates among young women in New Zealand. Study Design: Cohort study; Level of evidence, 2. Methods: Prospective data captured by the New Zealand ACL Registry between April 2014 and March 2022 were reviewed. Young women aged 15 to 20 years were included. The primary outcome measure was ACL graft failure during the study period, with the key independent variable being graft type, either patellar or hamstring tendon autograft. This is presented as the rate per 100 patient-years and is compared between the 2 groups using the hazard ratio generated from a Cox proportional hazards regression. Secondary outcome measures were Marx activity scores and the Knee injury and Osteoarthritis and Outcome Score patient-reported outcome measure. Results: A total of 1261 primary ACL reconstructions in young women aged 15 to 20 years were reviewed. Hamstring tendon grafts were used in 797 (63%) reconstructions and patellar tendon graft in 464 (37%) reconstructions. Patients with a hamstring tendon graft had a graft failure rate of 7.7% compared with 1.1% in patients with a patellar tendon graft (hazard ratio, 6.1; 95% CI, 2.4-15.1; P < .001). The number of failures per 100 person-years was significantly higher in the hamstring group (2.05) compared with the patellar tendon group (0.37). No difference was noted at final follow-up between the hamstring tendon and patellar tendon groups when comparing patient-reported outcome measures during the follow-up period. Conclusion: In the young female population of this study, the use of a patellar tendon graft was associated with reduced risk of graft failure and was not associated with an increase in knee morbidity. This highlights the importance of informed decision-making in this high-risk population when considering ACL reconstruction graft type.
Evaluation of the effects of manual acupuncture and electroacupuncture at LI4 and LI11 on perception thresholds: a prospective crossover trial
Authors: Oyamaguchi Aiko , Hanamoto Hiroshi , Tanaka Yoshiki , Takahashi Sayo , Niwa Hitoshi 
Published: January 2023

Objective: The objective of the study was to investigate and compare the effects of manual acupuncture (MA) and electroacupuncture (EA) on current perception thresholds (CPTs) using quantitative methods. Methods: Twenty-nine healthy volunteers participated in this prospective crossover trial, in which three acupuncture methods were compared: control, MA, and EA. Acupuncture needles were inserted to a depth of 15 mm at LI4 and LI11 on the left side and retained for 30 min with or without electrical stimulation at a frequency of 2 Hz (EA and MA, respectively). The needles were removed and participants rested for 30 min. CPT in the left mental region was measured at 2000, 250, and 5 Hz, corresponding to the activation of Aβ, Aδ, and C-fibers, respectively, at four time points: baseline, T0; 15 min after needle application, T1; immediately after needle removal, T2; and 30 min after needle removal, T3. In the control session, only a sensory test was performed (without acupuncture). Results: Significant effects of time course on CPT were observed ( p < 0.001). CPT values increased significantly at T1, T2, and T3, compared with those at T0, at all stimulation frequencies during MA and EA. Changes in CPT values with EA were not significantly greater than those with MA. Conclusions: Both MA and EA increased the sensory thresholds of Aβ, Aδ, and C-fibers in the mental region for ⩾30 min after needle removal. Additional of electrical stimulation may not confer additional benefits over needling alone. Trial registration number: UMIN000017983 (University Hospital Medical Information Network Clinical Trials Registry).
Delayed Extensive Local Reaction to the mRNA-1273 Vaccine against SARS-CoV-2: A Case Report
Authors: Ferreira-da-Silva Renato , Ribeiro-Vaz Inês , Silva Ana Marta , Nunes Fernando , Morato Manuela , Polónia Jorge Junqueira , Guedes Paulo 
Published: January 2023

In response to the COVID-19 pandemic, two mRNA vaccines (Comirnaty and Spikevax) received emergency use authorization from the European Medicines Agency. This case report aimed to report a delayed adverse reaction to the mRNA-1273 vaccine against COVID-19 from a Portuguese vaccination center. A case report was performed with medical observation and reported to the Portuguese Pharmacovigilance System, then investigated based on the WHO-UMC Causality Categories. A 66-year-old female patient with a clinical history of dyslipidemia, essential arterial hypertension, obesity, multinodular goitre and cholecystectomy, who presented delayed large cutaneous hypersensitivity reaction following Spikevax COVID-19 mRNA (mRNA-1273) vaccine administration. Our clinical findings (time and clinical appearance), along with evidence of previously reported histological findings, are strongly suggestive of T-cell-mediated hypersensitivity. There is no contraindication to the inoculation of subsequent doses in patients developing these clinical conditions, and vaccination should continue to be strongly encouraged.