bluuebunny/crossref_metadata_2025_split huggingface dataset:
A good preoperative immune prognostic index is predictive of better prognosis for locally advanced rectal cancer patients with ypTNM stage II who underwent radical resection after neoadjuvant chemoradiotherapy
Authors: Li Shoufeng , Wang Ye , Cai Huajun , Pan Zhen , Guan Guoxian 
Published: May 2023

Abstract
Background:
No studies have investigated the role of IPI in assessing the prognosis for LARC patients undergoing nCRT.
Objective:
We attempted to combine neutrophil-to-lymphocyte ratio (NLR) and serum lactate dehydrogenase (sLDH) to generate a new rectal immune prognostic index (RIPI) to explore whether RIPI is associated with the prognosis of LARC. And try to find out whether there is a population that might benefit from RIPI in LARC.
Methods:
Locally advanced rectal cancer (LARC) patients who underwent radical surgery after Neoadjuvant chemoradiotherapy (nCRT) from February 2012 to May 2017 were enrolled. Based on the best cut-off points of NLR and sLDH, we developed rectal immune prognostic index (RIPI). Patients were grouped as follows: 1) good, RIPI = 0, good, 0 factors; 2) poor, RIPI = 1, 1 or 2 factors.
Results:
A total of 642 patients were enrolled. In yp TNM stage II patients, there was a statistically significant difference in 5-year disease-free survival (DFS) (p=0.03) between RIPI=1 and RIPI=0 groups. In ypCR, stage I, stage II, and stage III, there was no significant difference in 5-year DFS between IPI=0 and IPI=1 groups. In multivariate analysis, the significant factor predicting DFS was RIPI score (p=0.035)
Conclusion:
RIPI was closely related to the prognosis of LARC patients undergoing nCRT. In particular, RIPI is of great significance in evaluating the prognosis of LARC patients with ypTNM stage II who underwent radical resection after nCRT.
Label Consistency Loss for Multi-label Decoding in Named Entity Recognition
Authors: Wang Chishe , Fan Kangnan , Wang Jie 
Published: May 2023

Abstract
Named entity recognition (NER) has beed studied well recent years. However, the diversity problem that arises while multiple labels are decoded into entities has been ignored in most studies. Concretely, in the process of decoding labels into entities, the same label prediction accuracy may lead to different entity prediction accuracy. This paper propose label consistency loss (LCL) to address the multi-label decoding diversity problem while considering the global label prediction accuracy. Specifically, the proposed method consists of two loss functions: global loss function and entity loss function. The global loss function is dedicated to improve the global label prediction accuracy by calculating the global error between predicted labels and gold labels. Entity loss is dedicated to solve the diversity problem by achieving labels in same entity are in the same prediction score distribution. To verify the effectiveness of LCL, this paper propose L2E metric which denote the conversion rate of labels to entities. Apply LCL to baseline and conduct experiments on two datasets. The experiment results show the F1 performance of baseline is improved by 1.16% percent and 0.17% percent, the L2E is improved by 1.52% and 0.03% on two datasets.
Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on bone healing after endodontic microsurgery
Authors: You Jae-Seek , Jung Gyeo-Woon , Oh Ji-Su , Moon Seong-Young , Lee Won-Pyo , Jo Hyoung-Hoon 
Published: May 2023

Abstract
Background This study evaluated the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on bone healing after endodontic microsurgery.Methods Eighteen patients with an isolated periapical lesion < 10 mm in the maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect at postoperative one week, three months, and six months was evaluated using cone-beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal–Wallis test and post-hoc Mann–Whitney U test with Bonferroni correction.Results At the three-month follow-up, the PRF and CGF groups showed significantly greater bone healing compared with the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups.Conclusions These results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.
DADLE promotes autophagic flux and depresses necroptosis by inhibiting cytosolic phospholipase A2 mediated lysosomal membrane permeabilization after spinal cord injury
Authors: Chen Yituo , Zhang Haojie , Jiang Liting , Cai Wanta , Kuang Jiaxuan , Geng Yibo , Xu Hui , Li Yao , Yang Liangliang , Cai Yuepiao , Wang Xiangyang , Xiao Jian , Ni Wenfei , Zhou Kailiang 
Published: May 2023

Abstract
Programmed cell death plays a critical role in the progression of spinal cord injury (SCI). Autophagy is a protective factor for controlling neuronal damage, while necroptosis promotes further cell death and neuroinflammation after SCI. DADLE (d-Ala2, d-Leu5) is a selective agonist for delta opioid receptor (DOR) and has been identified as a promising drug for its neuroprotective effects. Our present work aims to investigate the therapeutic effect of DADLE on locomotive function recovery following SCI and its concrete mechanism. By establishing a mouse model of spinal cord contusion injury and using functional behavioural assessment, our results showed that DADLE promoted functional recovery after SCI. Through experimental methods such as western blotting and immunofluorescence, we found that DADLE promoted autophagic flux and inhibited necroptosis. Then, analysis of the enzyme activity of NAG and related protein expression of CTSD and CTSB in lysosomes and cytoplasm revealed that DADLE decreased lysosomal membrane permeabilization (LMP). The autophagy inhibitor CQ reversed the protective effect of inhibiting necroptosis. Further analysis identified that DADLE decreased phosphorylated cPLA2, and network pharmacology analysis revealed that the AMPK (Adenosine monophosphate-activated protein kinase) signalling pathway may be involved in the therapeutic effect of DADLE. Finally, blocking the interaction between DOR and DADLE by using naltrindole abolished the anti-phosphorylation effect of DADLE on cPLA2 and p38, resulting in a decrease in autophagic markers and an increase in necroptosis and LMP markers. Altogether, our study indicated that DADLE promotes autophagic flux and inhibits necroptosis by decreasing LMP by interacting with DOR and then activating the AMPK/SIRT1/P38/cPLA2 pathway after SCI, which may have potential clinical application value in the future.
Bayesian Improved Surname Geocoding as an Efficient Alternative to Purchased Race and Ethnicity Data for Health Surveys
Authors: Suzuki Honoka , McRoy Martha , Connor Nora , Brinkley Jason 
Published: May 2023

Abstract

Race and ethnicity are a key demographic collected in health surveys that allow for important investigations into health disparities and efforts towards achieving health equity. In addition to collecting this information from survey respondents, the availability of high-quality race and ethnicity data on an entire survey sample, including respondents and nonrespondents, allows for additional important race-related investigations and procedures that enhance survey quality and analyses (e.g., oversampling, non-response follow-ups, weighting adjustments). While researchers may purchase auxiliary data, including race/ethnicity, from commercial data vendors to append to survey samples, such purchased data can be limited by concerns of accuracy, completeness, and cost. In this study, we explored Bayesian Improved Surname Geocoding (BISG), an indirect estimation method of race/ethnicity that relies on surnames and geocoded addresses widely used in health services research, as an alternative to purchasing this information from data vendors. Using the New York City Department of Health and Mental Hygiene’s 2021 Community Health Survey, we compared the accuracy of BISG’s race/ethnicity predictions to purchased race/ethnicity data, using the survey respondents’ self-reported race/ethnicity as the gold standard. We demonstrate that under certain conditions, BISG provides a promising, efficient alternative to purchasing race and ethnicity information, highlighting its potential to enhance quality of survey-based health research.
A Novel Laparoscopic Inguinal Hernia Repair Technique: Lateral Non-abdominal Pre-peritoneal Approach Running Head: A Novel Hernia Repair Technique: LNAPP
Authors: Avanaz Ali 
Published: May 2023

Abstract
Purpose: Open and endoscopic techniques have been described for the treatment of inguinal hernia, but the gold standard treatment method is yet to be defined. Recurrence rates after inguinal hernia surgery vary between 10-15%, and chronic pain is seen in 10-12% of patients. This study aimed to introduce a new surgical technique called lateral non-abdominal pre-peritoneal repair for inguinal hernia surgery.
Methods: We recorded the data of patients’ age, gender, body mass index (BMI), prior hernia surgery, hernia side, type of hernia, postoperative complications, pain scores according to the numeric pain scale, and analgesic consumption.
Results: Seventeen inguinal hernias were repaired with the new technique in 14 patients. Two of the patients were female. The median age was 59, and the mean BMI was 26.8. The median hospital stays and time passed since the surgery was 1 day, and 72 days, respectively. The mean operative time was 64 ±29 minutes. The median tramadol consumption was 100 mg, and the mean paracetamol consumption was 1143 mg. The median pain score on POD 1 and current pain score was 4 and 0, respectively.
Conclusions: No significant complications occurred intraoperatively. We observed the pain scores were acceptable on POD 1, and excellent in postoperative follow-up. Low pain scores, low analgesic consumption, and the absence of recurrence in a newly developed procedure within the learning curve indicate that satisfactory results can be obtained.
Dyslexia-Related Loci Are Significantly Associated With Language And Literacy In Chinese-English Bilingual Hong Kong Chinese Twins
Authors: Chung Cheuk Yan , Pan Dora Jue , Paracchini Silvia , Jiang Wenxuan , So Hon-Cheong , McBride Catherine , Maurer Urs , Zheng Mo , Choy Richard 
Published: May 2023

Abstract
A recent genome-wide association study on dyslexia in 51,800 affected European adults and 1,087,070 controls detected 42 genome-wide significant SNPs. Among the 42 SNPs, rs2624839 further showed a significant association with quantitative reading fluency in a Chinese replication cohort. This study aimed at replicating the association between loci near the reported dyslexia associated rs2624839 and quantitative measurements of language and literacy in a unique cohort of bilingual Hong Kong Chinese twins who speak Chinese as first language and English as second language. To investigate the region near dyslexia associated rs2624839, proxy SNPs (rs1005678, rs12632110, and rs12494414) were tested at the population level (n = 308) and the within-twin level (n = 344, 172 twin pairs). At population level, significant associations with Chinese and English vocabulary knowledge were observed for all the three SNPs (p < .05). The strongest significant association after multiple testing correction was between rs12494414 and English vocabulary knowledge at the within-twin level (p = .004). We also demonstrated a trend of associations with English word reading and spelling, but larger sample size study is required to validate our findings. However, there was no significant associations with Chinese word reading and spelling. Our result suggests an important contribution of dyslexia-associated SNPs to language and literacy in Chinese and English in bilingual Chinese twins.
Re-coherence Generated by Nonlinear Maps
Authors: Roth Yehuda 
Published: May 2023

Abstract
Coherence, the fundamental concept underlying quantum computers, is a complex phenomenon that limits their implementation. Coherent states can be non-stationary (i.e., not an eigenstate of the Hamiltonian), and system–environment interactions can cause decoherence. To adapt to environmental factors such as heat, the realization of quantum computers entails cold environments at temperatures close to absolute zero. Nonlinear dynamics can result from open systems (such as system–environment feedback interactions). Here we show that nonlinear maps characterized by a single attractor can cause mixed-density matrices to become pure and that implementing such nonlinear maps may provide a straightforward approach to realizing quantum computers.
The Temporal Dynamics of Dissociation: Protocol for an Ecological Momentary Assessment and Laboratory Study in a Transdiagnostic Sample
Authors: Heekerens Johannes B. , Gross James J. , Kreibig Sylvia D. , Wingenfeld Katja , Roepke Stefan 
Published: May 2023

Abstract
Background Dissociation is a ubiquitous clinical phenomenon. Dissociative disorders (DD) are primarily characterized by dissociation, and dissociative states are also a criterion for borderline personality disorder (BPD) and the dissociative subtype of post-traumatic stress disorder (PTSD). Dissociative reactions across diagnostic categories are believed to be affect contingent and theorized to serve affect regulation functions. What is not clear, however, is how self-reported affect and physiological reactivity unfold within dissociative episodes. To address this issue, the present project aims to investigate the hypothesis (1) whether self-reported distress (as indicated by arousal, e.g., feeling tense/agitated, and/or valence, e.g., feeling discontent/unwell) and physiological reactivity increase before dissociative episodes and (2) whether self-reported distress and physiological reactivity decrease during and after dissociative episodes in a transdiagnostic sample of patients with DD, BPD, and/or PTSD.Methods We will use a smartphone application to assess affect and dissociation 12 times per day over the course of one week in everyday life. During this time, heart and respiratory rates will be remotely monitored. Afterwards, participants will report affect and dissociative states eight times in the laboratory before, during, and after the Trier Social Stress Test. During the laboratory task, we will continuously record heart rate, blood pressure, electrodermal activity, and respiratory rate, and take salivary samples to determine cortisol levels. Our hypotheses will be tested using multilevel structural equation models. Power analyses determined a sample size of 85.Discussion The project will test key predictions of a transdiagnostic model of dissociation based on the idea that dissociative reactions are affect contingent and serve affect regulation functions. • This project will not include non-clinical control participants. In addition, the assessment of dissociation is limited to pathological phenomena.
High-throughput sheath-less microfluidic impedance cytometry for point of care applications
Authors: Hosseini Seied Ali , Bahrami Sanaz , Zolghadr Leila , Gheibi Nematollah 
Published: May 2023

Abstract
The present study introduces a microfluidic device that employs impedance measurement to accurately enumerate cells in suspension. Prior to the development of this device, impedance cytometry microfluidic chips necessitated the use of planar electrodes and sheath fluids, which complicated the system, or utilized small constricted regions that impeded cell movement and reduced operational efficiency. This newly developed device is capable of sensitive and rapid cell enumeration without the need for sheath fluid or planar electrodes, making it suitable for point of care applications. Instead of thin film electrodes, the same needles used for liquid injection were implemented for impedance measurement, thus simplifying the device. The physical parameters of the device were designed using analytical and computer aided simulations to determine the maximum dimensions required for sensitive detection of human cells. Simulations were also employed to investigate the effects of flow rates, cell shape, and injection method on device performance, and results were compared with experimental findings. Finally, this novel device was tested for its ability to count MCF7 cells at various flow rates and concentrations, with a limit of detection of 32.3 cells per µL being achieved.
Construction of a prediction model for rebleeding in patients with acute upper gastrointestinal bleeding
Authors: zhuang yangping , Xia Shaohuai , Chen Junwei , Ke Jun , Lin Shirong , Lin Qingming , Tang Xiahong , Huang Hanlin , Zheng Nan , Wang Yi , Chen Feng 
Published: May 2023

Abstract
Background
The incidence of rebleeding in patients with upper gastrointestinal bleeding (UGIB) remains despite advances in intervention approaches. Therefore, early prediction of the risk of rebleeding could help to greatly reduce the mortality rate in these patients.
We aim to develop and validate a new prediction model to predict the probability of rebleeding in patients with AUGIB.
Methods
A total of 1,170 AUGIB patients who completed the procedure of emergency gastroscopy within 48 h of admission were included. Logistic regression analyses were performed to construct a new prediction model. A receiver operating characteristic curve, a line graph, and a calibration and decision curve were used to assess the predictive performance of our new prediction model and compare its performance with that of the AIMS65 scoring system to determine the predictive value of our prediction model.
Results
A new prediction model was constructed based on Lactic acid (LAC), neutrophil percentage (NEUTP), platelet (PLT), albumin (ALB), and D-DIMER. The AUC values and their 95% confidence interval (CI) for the new prediction model and the AIMS65 score were 0.746 and 0.619, respectively, and 0.697–0.795 and 0.567–0.670, respectively. In the training group, the C index values based on the prediction model and the AIMS65 scoring system were 0.720 and 0.610, respectively. In the validation group, the C index values based on the prediction model and the AIMS65 scoring system were 0.828 and 0.667, respectively. The decision and calibration curve analysis also showed that the prediction model was superior to the AIMS65 scoring system in terms of accuracy of prediction, consistency, and net clinical benefit.
Conclusion
The prediction model can predict the probability of rebleeding in AUGIB patients after endoscopic hemostasis therapy.
MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells
Authors: Li Youzhu , Ye Yuanyuan , Zhang Hengyuan , Yang Ye , Zhang Ningqing , Gao Hong , Wu Rongfeng 
Published: May 2023

Abstract
Background: Endometriosis(EM) is a major cause of infertility, but the pathogenesis and mechanisms have not been fully elucidated. MiR-19b-3p is involved in many diseases, but its functional role in EM-associated infertility has not been investigated. In this study, we aimed to examine miR-19b-3p abundance and IGF1 concentration in cumulus cells (CCs) and follicular fluid in EM-associated infertility patients and to reveal the potential role of miR-19b-3p in KGN cells by identifying its target and elucidating the underlying mechanisms.
Results: The results showed that compared to the control group (patients with tubal infertility), EM-associated infertility patients had a lower percentage of mature oocytes. Abundance of miR-19b-3p was increased in CCs in EM-associated infertility patients. IGF1 was a direct target of miR-19b-3p and was negatively regulated by miR-19b-3p in KGN cells. Overexpression of miR-19b-3p significantly inhibited viability and proliferation, promoted apoptosis, and arrested cell cycle at G0/G1 phase in KGN cells. The effects of miR-19b-3p could be reversed by co-transfection of IGF1 and the biological effects of miR-19b-3p in KGN cells were mediated by IGF1. In addition, miR-19b-3p targeted IGF1 to downregulate AKT phosphorylation and to participate in apoptotic pathway in KGN cells.
Conclusions: This study demonstrates that miR-19b-3p abundance is increased in CCs and IGF1 concentration is decreased in follicular fluid in EM-associated infertility patients, and miR-19b-3p participates in the regulation of biological effects of KGN cells by targeting IGF1.
Cavitating and Non-cavitating Lumped Vortex Element under a Free Surface
Authors: Bal Sakir 
Published: May 2023

Abstract
In this study, the lift and moment coefficients of two-dimensional cavitating and non-cavitating flat-plate moving with a constant speed under a free surface have been calculated by a closed - form solution. The cavitation (if exists) volume has also been computed in case of cavitating flat-plate. The flat-plate has been modeled by a lumped vortex element under the constraints of potential flow theory. Linearized free surface condition has been applied and then the total velocity potential has been computed by the method of images. Cavitation effect has been included into the calculations by considering an additional angle of attack in the case of fully wetted solution. The wave elevations on the free surface have also been calculated in a closed form solution. The lift coefficients by the present solution have been validated with those of Plotkin’s method. The effects of Froude number, submergence depth of flat-plate from calm free surface, angle of attack and cavitation number on the results (namely lift and moment coefficients, cavitation volume and free surface deformations) have been discussed in a detailed manner
Right Atrial Myxoma- a Rare Obstructive Free Floating Pedunculated Cardiac Tumor
Authors: Kanna D.E.Nirman , RAVI  , BABU NARENDRA , PACKIRISAMY SUBBULAKSHMI 
Published: May 2023

Abstract
Atrial myxoma is a rare cardiac disease but has a broad clinical presentation and complication that involves in heart, lungs, brain, and systemic circulation, among them right atrial myxoma is too rare. Commonly atrial myxomas are often pedunculated and soft in texture, it may be intact or free floated in the upper chambers of heart. The myxoma diameter varies from 10 to 150 mm with a weight of between 15 and 180 grams, which is present by a smooth, villous, soft or friable surface. The embolic events are associated with villous and friable myxomas, while the smooth myxomas are associated with obstructive type and are usually large in size. Proper preoperative evaluation and multidisciplinary teamwork helps to improve the post operative outcome, at the same time it reduces the intraoperative risks and increases the chance of survival of the patient. In this case study we had presented a successful excision of rare case of large free-floating pedunculated right atrial myxoma.
Optimal Antenna Design in the Cancer Tissues Treatment by Hyperthermia: A Review Study
Authors: Bozorgmanesh Mohammad Amin , Sadeghi Mojtaba 
Published: May 2023

Abstract
Although cancer is a recognized disorder worldwide, its treatment is a great challenge; and new and effective treatment methods become one of the fundamental demands. However, one of the new treatment approaches for cancer is hyperthermia, which is considered an assistant to surgery, chemotherapy, and radiotherapy. Despite the proven effectiveness of the method, there are numerous challenges in applying it that require recognizing the effective parameters and optimizing them to achieve better and more effective performance. Considering this, the review paper aims to study the optimization of antennas utilized in the cancerous tissue treatment by hyperthermia. However, four different antennas with different purposes are studied and optimized for this purpose. Furthermore, studies show that recognizing and optimizing the design parameters of hyperthermia antennas is likely to greatly improve the performance of the method.