bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic metabolomics characterization of the ascending and descending property
Authors: Liu Tong , Zhou Ning , Fu Yang , Feng Weisheng , Zheng Xiaoke 
Published: August 2023

Abstract
Background

According to the theory of TCM, ascending medicine has the effects of elevating yang, raising drooping, and inducing sweating. Descending medicine has the effects of relieving dyspnea and hiccup, stopping reflux, and calming nerves. In conclusion, the ascending/descending properties of TCM serve as a guide for the use of TCMs in clinical practice. However, at present, there are few studies on the ascending/descending properties of TCM. This study aimed to compare the effects of 6 ascending and 8 descending medicine on the main organs (heart, liver, lung, spleen, and kidney) of normal rats, characterizing the ascending and descending properties.

Methods

The orgain samples of all experiment group were analyzed based on ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOFMS). Then, to character the ascending and descending properties, the effects of 6 ascending and 8 descending medicine on the main organs (heart, liver, lung, spleen, and kidney) of normal rats were compared.

Results

The systemic metabolomics results indicated that linoleic acid metabolism and arginine and proline metabolism were the major differential pathways affected by ascending/descending medicine in the heart; nicotinic acid and nicotinamide metabolism, glutamic acid and glutathione metabolism, and L-carnitine metabolism were the major differential pathways affected by ascending/descending medicine in the liver; tryptophan metabolism, phenylalanine metabolism, and pyroglutamic acid and glutamic acid metabolism were the major differential pathways affected by ascending/descending medicine in the lung; tryptophan metabolism, phenylalanine metabolism, and glutamic acid metabolism were the major differential pathways affected by ascending/descending medicine in the kidney; and glutamic acid and glutamine metabolism were the major differential pathway affected by ascending/descending medicine in the spleen.

Conclusions

Ascending medicine exhibited positive effects on nerve stimulation, immunity, and reproductive function by promoting energy metabolism in the heart and liver, whereas descending medicine had the opposite effect. Descending medicine exhibited a positive effect on diuresis by promoting blood circulation, whereas ascending medicine had the opposite effect. Both descending medicine and ascending medicine intervened with pulmonary inflammation, but the underlying mechanisms may be different. This study demonstrated that systemic metabolomics technology can be used for the characterization of traditional Chinese medicine properties.
Influence of temperature and spin-orbit interaction on the effective mass of polaron in an anisotropic quantum dot
Authors: Shan Shu-Ping 
Published: August 2023

Abstract
Using Tokuda's improved linear combination operator method and variational technique, the expression of the effective mass of strong coupled polaron in an anisotropic quantum dot is derived. Due to the spin orbit interaction, the effective mass of polaron splits into two branches. The dependence of effective mass on temperature, electron-phonon coupling strength, transverse and longitudinal confinement lengths and velocity is discussed by numerical calculation. The effective mass of polaron is an increasing function of temperature and electron-phonon coupling strength, and a decreasing function of transverse confinement length, longitudinal confinement length, and velocity. The absolute value of spin splitting effective mass increases with the increase of temperature and spin orbit coupling parameter, and decreases with the increase of transverse confinement length, longitudinal confinement length and velocity. Due to the heavy hole characteristic, the spin splitting effective mass is negative.
Prognostic analysis based on multi-features calculation and clinical information fusion of colorectal cancer whole slide pathological image
Authors: Cai Chengfei , Zhou Yangshu , Wang Xiangxue , Jiao Yiping , Liang Li , Xu Jun 
Published: August 2023

Abstract
Background: Colorectal cancer (CRC) is a malignant tumor within digestive tract with both high incidence rate and and mortality. Early detection and intervention could improve patient clinical outcome and survival.
Methods: This study computationally investigate a set of prognostic tissue and celluer features from diagnostic tissue slide. With the combination of clinical prognostic variable, the pathological image features could predict the prognosis in CRC patients.ur CRC prognosis prediction pipeline is sequentially consisted of three modules: (1) A DeepTissue Net to delineate outlines of different tissue types within the WSI of CRC for further ROI selection by pathologist; (2) Development of three-level quantitative image metrics related to tissue compositions, cell shape and hidden features from deep network; (3) Fusion of multi-level features to build a prognostic CRC model for predicting survival for CRC.
Results: Experimental results suggest that each group of features has a certain relationship with the prognosis of patients in the independent test set. In the fusion features combination experiment, the accuracy rate of predicting patients' prognosis and survival status is 81.52%, and the AUC value is 0.77.
Conclusion: This paper constructs a model that can predict postoperative survival of patients by using image features and clinical information.Some features were found to be associated with the prognosis and survival of patients.
Identification of Necroptosis-related Molecular Subtypes and
Construction of Necroptosis-related Gene Signature for Glioblastoma
Multiforme
Authors: Li Zhiyong , Jin Yinghui , Que Tianshi , Zhang Xi-An , Yi Guozhong , Zheng Haojie , Yuan Xi , Wang Xiaoyan , Xu Haiyan , Nan Jing , Chen Chao , Wu Yuankui , Huang Guanglong 
Published: August 2023

Background:
Necroptosis is a highly regulated and genetically controlled process, and
therefore, attention has been paid to the exact effects of this disorder on a variety of diseases, including
cancer. An in-depth understanding of the key regulatory factors and molecular events that
trigger necroptosis can not only identify patients at risk of cancer development but can also help to
develop new treatment strategies.

Aims:
This study aimed to increase understanding of the complex role of necroptosis in glioblastoma
multiforme (GBM) and provide a new perspective and reference for accurate prediction of
clinical outcomes and gene-targeted therapy in patients with GBM. The objective of this study
was to analyze the gene expression profile of necroptosis regulatory factors in glioblastoma multiforme
(GBM) and establish a necroptosis regulatory factor-based GBM classification and prognostic
gene signature to recognize the multifaceted impact of necroptosis on GBM.

Methods:
The necroptosis score of the glioblastoma multiforme (GBM) sample in TCGA was
calculated by ssGSEA, and the correlation between each gene and the necroptosis score was calculated.
Based on necroptosis score-related genes, unsupervised consensus clustering was employed
to classify patients. The prognosis, tumor microenvironment (TME), genomic changes, biological
signal pathways and gene expression differences among clusters were analyzed. The
gene signature of GBM was constructed by Cox and LASSO regression analysis of differentially
expressed genes (DEGs).

Result:
Based on 34 necroptosis score-related genes, GBM was divided into two clusters with
different overall survival (OS) and TME. A necroptosis-related gene signature (NRGS) containing
8 genes was developed, which could stratify the risk of GBM in both the training set and verification
set and had good prognostic value. NRGS and age were both independent prognostic indicators
of GBM, and a nomogram developed by the integration of both of them showed a better
predictive effect than traditional clinical features.

Conclusion:
In this study, patients from public data sets were divided into two clusters and the
unique TME and molecular characteristics of each cluster were described. Furthermore, an
NRGS was constructed to effectively and independently predict the survival outcome of GBM,
which provides some insights for the implementation of personalized precision medicine in clinical
practice.
Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's
Disease: An Update
Authors: Semwal Bhupesh Chander , Singh Bhoopendra , Murti Yogesh , Singh Sonia 
Published: August 2023

Background:
Ascorbic acid is a potent natural antioxidant that protects against
oxidative stress and performs various bodily functions. It is commonly found in fruits and
vegetables.

Objective:
The manuscript has been written to provide valuable insights into ascorbic acid in
managing Alzheimer's disease.

Methods:
The data has been gathered from web sources, including PubMed, Science Direct,
Publons, Web of Science, and Scopus from 2000-2022 using AA, ascorbic acid, Alzheimer’s diseases, memory, dementia, and antioxidant Keywords.

Results:
In the present manuscript, we have summarized the impact of ascorbic acid and its possible mechanism in Alzheimer's disease by, outlining the information currently available on the
behavioral and biochemical effects of ascorbic acid in animal models of Alzheimer's disease as
well as its usage as a therapeutic agent to slow down the progression of Alzheimer disease in human beings. Oxidative stress plays a significant role in the advancement of AD. AA is a wellknown antioxidant that primarily reduces oxidative stress and produces protein aggregates, which
may help decrease cognitive deficits in Alzheimer's disease. The current paper analyses of ascorbic acid revealed that deficiency of ascorbic acid adversely affects the central nervous system and
leads to cognitive defects. However, the results of clinical studies are conflicting, but some of the
studies suggested that supplementation of ascorbic acid improved cognitive deficits and decreased
disease progression.

Conclusion:
Based on clinical and preclinical studies, it is observed that ascorbic acid supplementation improves cognitive deficits and protects the neurons from oxidative stress injury
Amyloid-β-Induced Transglutaminase 2 Expression and Activities are
Modulated by 2-Pentadecyl-2-Oxazoline in Mouse and Human Microglial
Cell Lines
Authors: Parente Andrea , Giacca Rosa , Arena Roberta , Rullo Ilenia , Guida Francesca , Maione Sabatino , Gentile Vittorio 
Published: August 2023

Background:
Transglutaminase 2 is a ubiquitous multifunctional enzyme and the best studied of the transglutaminase family. Consistent with its role in promoting post-translational modifications of proteins, Transglutaminase 2 is involved in many physiological processes such as apoptosis, signal transduction, and cellular adhesion. Several findings indicate that Transglutaminase 2 plays a role in the pathological processes of various inflammation-related diseases, including neurodegenerative diseases.

Objective:
We tested the potential modulatory effects on amyloid-β–induced Transglutaminase 2 expression and activities of 2-pentadecyl-2-oxazoline, a plant-derived agent, which has shown effectiveness against chronic pain and associated neuropsychiatric disorders, both in mouse and human microglial cell lines.
Methods: We used biochemistry, molecular and cell biology techniques to evaluate the potential modulatory effects on amyloid-β – induced Transglutaminase 2 expression and activities of 2- pentadecyl-2-oxazoline in mouse and human microglial cell lines.

Results:
2-pentadecyl-2-oxazoline was able to modulate amyloid-β–induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.

Conclusion:
Transglutaminase 2 confirms its role as a neuroinflammation marker, the inhibition of which could be a potential preventive and therapeutic approach, while 2-pentadecyl-2-oxazoline is a potent modulator of the amyloid-β–induced Transglutaminase 2 expression and activities in mouse and human microglial cell lines.
Rare and First Manifestation of Lupus Panniculitis as Lupus Mastitis: A Case
Report and Literature Review
Authors: Yong Guo Chong , Chen Li , Sun Lin , Shan Yang Xiao , Mao Ruiqi , Cheng Li Bo , Jun Li Xin , Zhou Ling 
Published: August 2023

Introduction:
This case report presents a rare occurrence of lupus mastitis affecting the breast.

Case Presentation:
An induration with mild discomfort was detected in the upper inner quadrant of the right breast of a 27-year-old Chinese woman with regular menstrual cycles. The patient is currently unmarried and has no previous history of full-term pregnancies or lactation. An ill-defined, subcutaneous, hyperechoic lesion with no calcification was visualized on breast ultrasound. Peripheral and internal blood flow signals demonstrated high intensity. Pathological analysis of a breast needle biopsy revealed fat lobule necrosis accompanied by mixed lymphoplasmacytic and histiocytic aggregates.

Conclusion:
The diagnosis of lupus mastitis necessitates a comprehensive evaluation of the patient's medical history, serological testing, imaging studies, and histopathological analysis.
Criticism of the HAS Opinion of July 21st, 2022, on Maintaining of the
SARS-Cov-2 Vaccine Mandate for Healthcare Workers
Authors: Sainton Jérôme 
Published: August 2023

Abstract:
The opinion of the French National Authority for Health (HAS) on July 21st, 2022, concluded
that the mechanism of the SARS-Cov-2 vaccine mandate for caregivers and other health professionals
should be maintained. Constructed as a syllogism, the opinion states that the benefit-risk balance of a
three-dose vaccination schedule to limit transmission is favorable (major premise) and that this balance
necessarily determines the mechanism of SARS-Cov-2 vaccine mandate (minor premise) so that it should
be maintained (conclusion). Each of these steps is flawed. First, the benefit-risk analysis of a three-dose
vaccination schedule is many times distorted: it fails to transpose the relative efficacy of the vaccination
in terms of absolute efficacy; it fails to take into account both the particularly poor efficacy of the vaccination
against the risk of infection (symptomatic or not) and its decrease, or even negativation, over
time, as well as the worsening of the vaccine escape with the latest Omicron sub-lineages; it does not
assess the risk associated with the mechanism, particularly with regard to COVID convalescents and
pregnant women. Secondly, the inference made from this analysis to the specific mechanism of mandatory
vaccination of caregivers is distorted. There is no refocusing on the specific population of caregivers,
and the real and concrete benefit of the mechanism itself is not measured. Thirdly, the very construction
of the reasoning is distorted. By reducing a medical problem to the calibration of a strictly technical benefit-
risk balance, it evades the intrinsic practical and ethical dimensions of the issue.
40Ar/39Ar Age and Structural Constraints on Permian-Triassic and Jurassic Tectono-Metamorphic and Exhumation Phases in the Korean Collision Belt and Tectonic Implications
Authors: Jong Koen De , Ruffet Gilles , Han Seokyoung 
Published: August 2023

The Korean Collision Belt originally constituted a single coherent
southwards-thinning tectonic wedge formed by accretion of the
Qinling-type Barrovian metamorphic Jingok and Samgot units (Yeoncheon
Complex) and Taean Formation onto the Sino–Korean Craton’s southern
extension (Precambrian Gyeonggi Massif) while being underthrust by the
South China Block. Detailed structural geological study and
Ar/Ar laser-probe dating of 47
mineral single-grain and 2 whole-rock samples with both syn-collisional
peak metamorphic and retrograde mineral assemblages reveal a prolonged
tectonic evolution from the Devono–Carboniferous pre-collisional stage
(375–370 Ma; ~315 Ma) to the Midde–Late Jurassic
reactivation of the Permian–Triassic wedge during the second major
exhumation phase of the Gyeonggi Massif (194–165 Ma). The latest
Permian to Late Triassic main orogeny comprises three distinct
correlated tectono-metamorphic phases. Essentially concordant
(pseudo-)plateau ages (255.2–249.9 ± 0.4–0.9 Ma, 1σ) for
main-phase-fabric-forming muscovite and biotite in the garnet,
staurolite and kyanite zones and discordant late-stage andalusite-quartz
veins (Jingok Unit) show fast cooling during exhumation from
~30 km to ≤12.5 km. Hornblendes (248.8–247.0 ± 0.6–1.6
Ma, 1σ) in the underlying higher-grade metamorphic, deeper underthrust
Samgot Unit show later cooling. Fabric asymmetry implies cooling and age
differences stem from (S)SE-ward exhumation along low-angle ductile
normal faults. Incipient exhumation of mid-Triassic eclogites (Hongseong
Belt) induced strong tectono-metamorphic reworking of the overriding
plate (242–237 Ma; Yeoncheon Complex, Taean Formation, Gyeonggi
Massif). Structurally downwards increasing resetting of mica (225–220
Ma), retrogression and overprinting by top-to the-north
post-main-phase-shear constrains the Gyeonggi Massif’s further
exhumation and cooling.

Key Points:

Korean Collision Belt: a southwards-tapering tectonic wedge
with discrete tectono-metamorphic phases at 255–247, 245–237, 225–220
Ma
255–247 Ma: fast cooling, rapid exhumation, top-to-SE normal shear;
225–220 Ma: downwards increase retrogression, top-to-N normal shear
245–237 Ma: strong reworking; exhumation mid-Triassic eclogite;
194–165 Ma: final metamorphic reactivation and top-to-N normal shear
Evaluation of bisphenol release of different clear aligner materials using the liquid chromatography-mass spectrometry/mass spectrometry method
Authors: Çifçi Özkan Esra , Dumanlı Gök Gülay 
Published: August 2023

ABSTRACT

Objectives
To evaluate the bisphenol release of different brands of clear aligner materials.

Materials and Methods
Six different clear aligner materials were used in this study: Duran (Scheu-Dental GmbH, Iserlohn, Germany), Zendura Flx (Bay Materials LLC, Fremont, CA, USA), Zendura A (Bay Materials), Essix (Raintree Essix Inc., Metairie, LA, USA), Taglus Premium (Laxmi Dental Export Pvt. Ltd, Mumbai, India), and Smart Track (Align Technology, San Jose, CA, USA). The samples were kept in saline solution for 8 weeks in airtight test tubes at 37°C. The ratio between the weights of the samples and the volumes of the dilutions was prepared as 0.1 g/mL as suggested by International Standards Organization parameters. To evaluate the bisphenol release of materials, liquid chromatography-mass spectrometry/mass spectrometry analysis was performed. Data were analyzed with the Kruskal-Wallis test (α = 0.05).

Results
Bisphenol A (BPA) values in Smart Track were found to be significantly higher than the Zendura A and Zendura Flx groups (P = .02, P = .03, respectively). There was no statistically significant difference among the samples in terms of Bisphenol F (BPF) values (P = .108). In terms of Bisphenol S (BPS) values, a statistically significant difference was found (P = .002) indicating that Smart Track released significantly more BPS than Zendura A (P = .001).

Conclusions
Under the test conditions, the amounts of leached BPA, BPF, and BPS were less than the reference dose for daily intake. However, the cumulative effect of these appliances should not be underestimated.
Jenter og gutters vennskap og sosial inkludering ved skolestart
Authors: Håøy Annbjørg , Andreassen Becher Aslaug 
Published: August 2023

Fra en casestudie (Becher & Håøy, 2022) henter vi data og utforsker jenter og gutters vennskap og sosiale inkludering ved skolestart. Det empiriske hovedgrunnlaget er fokusgruppe-intervjuer med elever, foreldre og lærere i tillegg til barnas egne bilder. Mulighetene for å finne venner og delta i aktiviteter ser ut til å være noe ulike for jenter og gutter. De fleste guttene er opptatt av fotball, mens jentene engasjerer seg i andre aktiviteter. Det er krevende å finne nye lekekamerater i en stor, ny og ukjent barnegruppe, og både jenter og gutter kan oppleve utenforskap. Studien bekrefter at det kan være lettere for barn å etablere gode sosiale relasjoner, oppleve tilhørighet til fellesskap og føle seg inkludert når de begynner på skolen sammen med kjente barn. Men, vi finner at barna trenger støtte fra lærere for å opprettholde disse relasjonene. Videre finner vi at prestasjoner og ferdigheter vektlegges fra skolestart, noe som kan svekke fokus på sosial inkludering, kontinuitet og trygghet.
English abstract
Girls’ and Boys’ Friendships and Social Inclusion at the Start of School

From a case study (Becher & Håøy, 2022) we use data as we explore girls’ and boys’ friendships and social inclusion at the start of school. The main basis for data is focus group interviews with students, parents, and teachers as well as children’s photos. The possibilities for finding friends are somewhat different for girls and boys. Most of the boys are playing football, while the girls engage in other activities. It is challenging to find new playmates in a large, new, and unknown community of children, and both girls and boys can experience exclusion. The study confirms that it may be easier for children to establish positive social relationships, get a sense of belonging to community and feel included when they start school with children they already know. However, we find that children need support from teachers to maintain established relationships. Furthermore, we find that there is a strong focus on performance and skills from the beginning. This can weaken the emphasis on social inclusion, continuity and belonging at the start of school.
Nilai Kearifan Lokal dalam E-LKS Berbasis Wayang Sukuraga sebagai Perwujudan Profil Pelajar Pancasila
Authors: Andhini Gina Prilya , Nurasiah Iis , Nurmeta Irna Khaleda 
Published: August 2023

Media yang masih digunakan dalam proses pembelajarannya yaitu masih menggunakan buku, dan ternyata hasilnya tidak terjadi peningkatan secara signifikan dalam proses pembelajarannya. Penelitian ini bertujuan untuk menciptakan nilai kearifan lokal dalam E-LKS berbasis wayang sukuraga sebagai perwujudan profil pelajar pancasila. Jenis penelitian ini adalah R&D (Research And Development). Model pengembangan yang diperlukan dalam penelitian ini yaitu bentuk pengembangan ADDIE. Subjek dari penelitian ini diantaranya yaitu 2 ahli media, 2 ahli materi, guru dan 25 siswa kelas V sekolah dasar. Penelitian ini menggunakan instrument berupa lembar validasi ahli media dan ahli materi untuk mendapatkan hasil uji validitas dan juga angket respon siswa dan guru untuk mendapatkan hasil uji kepraktisan dari E-LKS tersebut. Hasil dari penelitian ini menunjukan bahwa penilaian ahli media dan ahli materi dihasilkan nilai sebesar 90,5 % d yang berarti pada rentang 81%-100% yaitu berada pada kategori Sangat Valid. Respon guru sebesar 89.60% dan skor dari siswa sebesar 80%. Jadi, diperoleh rata-rata skor guru dan siswa sebesar 85 % yang berarti E-LKS yang dikembangkan ini memiliki kriteria sangat praktis. E-LKS yang dikembangkan memiliki kualitas yang baik sehingga dapat membantu dalam proses pembelajaran.