bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of visually induced motion sickness on driving performance in a virtual reality simulator and the efficacy of airflow as a countermeasure
Authors: Igoshina Elizaveta (Liza) 
Published: September 2023

<p><strong>Background</strong>: Virtual reality (VR) driving simulation technologies have a myriad of applications from entertainment to scientific and medical research. However, they also are known to cause visually induced motion sickness (VIMS), a special form of traditional motion sickness. Common side effects of VIMS include nausea and disorientation, suggesting VIMS can bias driving performance. Objectives: We (1) investigated how VIMS affects performance in a simulated driving task and (2) examined a potential treatment to reduce VIMS through in-vehicle ventilation. </p>
<p><strong>Method</strong>: Twenty-three participants were engaged in a driving task where they react to hazards, obey speed limits, and complete common driving maneuvers. Driving performance (Objective 1) was evaluated based on various common driving criteria and compared between high- and low VIMS groups. To study the effect of airflow on VIMS (Objective 2), for half of the participants the car vents were positioned to face the drivers head and torso having airflow directly contact the driver’s skin, creating the experimental group: airflow (direct, indirect). The level of VIMS was measured before and after the simulated drive. </p>
<p><strong>Results</strong>: We found no differences in VIMS severity between airflow groups, indicating both direct and indirect airflow were equally successful prophylaxes to VIMS. We found no differences in driving performance between participants who experienced high- and low VIMS, indicating driving performance was not influenced by VIMS. Conclusion: Due to their equal prophylactic effects, both direct and indirect airflow can be used as a low cost, effective means of reducing VIMS in VR driving simulators. Furthermore, as driving-performance was not affected by VIMS, driving-simulator results of participants who experience high levels of VIMS can be treated equal to participants who experience low levels of VIMS. As these results are preliminary given we were unable to reach our minimum sample size of 40 participants, more data collection is required in order to be able to make a concrete conclusion.</p>
Role and Competencies Development of Librarians in Digital Era
Authors: Mustar Maniso , Rahmadanita Annisa 
Published: September 2023

Background: Technology advancement has experienced a rapid increase in digital era, but not all librarians possess the qualified competencies to address the associated challenges.
Objective: This study aims to analyze role and competency development of contemporary librarians in the digital era.
Method: The methodology used includes bibliographic content analysis and descriptive study.
Results: The result showed that contemporary librarians should take the initiative to meet information requirements of users. Librarians need to stay abreast of information technology advancement, keep pace with development in digital libraries, act as problem solvers, and enhance their skills. The discussion concerning role and competencies of contemporary librarians showed that they should serve as trailblazers in the field of information and technology.
Conclusion: In conclusion, competencies required for contemporary librarians in digital era include the ability to analyze and use information, manage time, and use information technology. Contemporary librarians must be capable of collaborating with other staff to achieve organizational goals

Keywords: contemporary librarians; information; competencies; information technology.

Abstrak

Latar Belakang: Kemajuan teknologi mengalami peningkatan pesat di era digital, namun tidak semua pustakawan memiliki kompetensi yang mumpuni untuk menjawab tantangan terkait.
Tujuan: Penelitian ini bertujuan untuk menganalisis peran dan pengembangan kompetensi pustakawan masa kini di era digital.
Metode: Metodologi yang digunakan meliputi analisis isi bibliografi dan studi deskriptif.
Hasil: Hasil penelitian menunjukkan bahwa pustakawan masa kini harus mengambil inisiatif untuk memenuhi kebutuhan informasi pengguna. Pustakawan perlu mengikuti kemajuan teknologi informasi, mengikuti perkembangan perpustakaan digital, bertindak sebagai pemecah masalah, dan meningkatkan keterampilan mereka. Pembahasan mengenai peran dan kompetensi pustakawan masa kini menunjukkan bahwa mereka harus menjadi pelopor di bidang informasi dan teknologi.
Kesimpulan: Kompetensi yang diperlukan bagi pustakawan masa kini di era digital antara lain kemampuan menganalisis dan menggunakan informasi, mengatur waktu, dan memanfaatkan teknologi informasi. Pustakawan masa kini harus mampu berkolaborasi dengan staf lain untuk mencapai tujuan organisasi

Kata Kunci: pustakawan kontemporer; informasi; kompetensi; teknologi Informasi.
Potential involvement of the bone marrow in experimental Graves’ disease and thyroid eye disease
Authors: Gulbins Anne , Horstmann Mareike , Keitsch Simone , Soddemann Matthias , Wilker Barbara , Wilson Gregory C. , Zeidan Ryan , Hammer Gary D. , Daser Anke , Bechrakis Nikolaos E. , Görtz Gina-Eva , Eckstein Anja 
Published: September 2023

IntroductionGraves’ disease is an autoimmune disorder caused by auto-antibodies against the thyroid stimulating hormone receptor (TSHR). Overstimulation of the TSHR induces hyperthyroidism and thyroid eye disease (TED) as the most common extra thyroidal manifestation of Graves’ disease. In TED, the TSHR cross talks with the insulin-like growth factor 1 receptor (IGF-1R) in orbital fibroblasts leading to inflammation, deposition of hyaluronan and adipogenesis. The bone marrow may play an important role in autoimmune diseases, but its role in Graves’ disease and TED is unknown. Here, we investigated whether induction of experimental Graves’ disease and accompanying TED involves bone marrow activation and whether interference with IGF-1R signaling prevents this activation.ResultsImmunization of mice with TSHR resulted in an increase the numbers of CD4-positive T-lymphocytes (p ≤0.0001), which was normalized by linsitinib (p = 0.0029), an increase of CD19-positive B-lymphocytes (p= 0.0018), which was unaffected by linsitinib and a decrease of GR1-positive cells (p= 0.0038), which was prevented by linsitinib (p= 0.0027). In addition, we observed an increase of Sca-1 positive hematopietic stem cells (p= 0.0007) and of stromal cell-derived factor 1 (SDF-1) (p ≤0.0001) after immunization with TSHR which was prevented by linsitinib (Sca-1: p= 0.0008, SDF-1: p ≤0.0001). TSHR-immunization also resulted in upregulation of CCL-5, IL-6 and osteopontin (all p ≤0.0001) and a concomitant decrease of the immune-inhibitory cytokines IL-10 (p= 0.0064) and PGE2 (p ≤0.0001) in the bone marrow (all p≤ 0.0001). Treatment with the IGF-1R antagonist linsitinib blocked these events (all p ≤0.0001). We further demonstrate a down-regulation of arginase-1 expression (p= 0.0005) in the bone marrow in TSHR immunized mice, with a concomitant increase of local arginine (p ≤0.0001). Linsitinib induces an upregulation of arginase-1 resulting in low arginase levels in the bone marrow. Reconstitution of arginine in bone marrow cells in vitro prevented immune-inhibition by linsitinib.ConclusionCollectively, these data indicate that the bone marrow is activated in experimental Graves’ disease and TED, which is prevented by linsitinib. Linsitinib-mediated immune-inhibition is mediated, at least in part, by arginase-1 up-regulation, consumption of arginine and thereby immune inhibition.
Neural sensory stimulation does not interfere with the H-reflex in individuals with lower limb amputation
Authors: Li Suzhou , Triolo Ronald J. , Charkhkar Hamid 
Published: September 2023

IntroductionIndividuals with lower limb loss experience an increased risk of falls partly due to the lack of sensory feedback from their missing foot. It is possible to restore plantar sensation perceived as originating from the missing foot by directly interfacing with the peripheral nerves remaining in the residual limb, which in turn has shown promise in improving gait and balance. However, it is yet unclear how these electrically elicited plantar sensation are integrated into the body’s natural sensorimotor control reflexes. Historically, the H-reflex has been used as a model for investigating sensorimotor control. Within the spinal cord, an array of inputs, including plantar cutaneous sensation, are integrated to produce inhibitory and excitatory effects on the H-reflex.MethodsIn this study, we characterized the interplay between electrically elicited plantar sensations and this intrinsic reflex mechanism. Participants adopted postures mimicking specific phases of the gait cycle. During each posture, we electrically elicited plantar sensation, and subsequently the H-reflex was evoked both in the presence and absence of these sensations.ResultsOur findings indicated that electrically elicited plantar sensations did not significantly alter the H-reflex excitability across any of the adopted postures.ConclusionThis suggests that individuals with lower limb loss can directly benefit from electrically elicited plantar sensation during walking without disrupting the existing sensory signaling pathways that modulate reflex responses.
Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice
Authors: Xie Jin-Bo , Xie Peng , Guo Mei , Li Fang-Fang , Xiao Man-Yu , Qi Yan-Shuang , Pei Wen-Jing , Luo Hao-Tian , Gu Yu-Long , Piao Xiang-Lan 
Published: September 2023

Glucose metabolic disorders (GMD) can promote insulin resistance (IR) and diabetes, and damage liver and kidney. Gynostemma pentaphyllum is commonly used in the clinical treatment of diabetes, but the research on its main active constituents and GMD has not been reported yet. This study explores the therapeutic potential of gypenosides of heat-processed Gynostemma pentaphyllum (HGyp) on high-fat diet-induced GMD in mice. HGyp was administered at different doses for 12 weeks. The investigation encompassed an array of parameters, including body weight, blood lipids, blood glucose, and liver tissue components. Metabolomic and network analyses were conducted to uncover potential targets and pathways associated with HGyp treatment. The results revealed that HGyp alleviated GMD by reducing body weight, blood glucose, and improving blood lipids levels, while increasing liver glycogen and antioxidant enzyme levels. Additionally, HGyp exhibited protective effects on liver and kidney health by reducing tissue damage. Fourteen blood components were detected by LC-MS. Metabolomic and network analyses indicated the potential engagement of the AGE-RAGE signaling pathway in the therapeutic effects of HGyp.Furthermore, Western blot and ELISA assays confirmed that HGyp upregulated GLO1 and GLUT4 while down-regulating AGEs and RAGE expression in liver tissue. In light of these findings, HGyp demonstrates promise as a potential therapeutic candidate for combating GMD, warranting further exploration in the development of therapeutic strategies or functional products.
A glycosylation risk score comprehensively assists the treatment of bladder neoplasm in the real-world cohort, including the tumor microenvironment, molecular and clinical prognosis
Authors: Liu Jinhui , He Yunbo , Zhou Weimin , Tang Zhuoming , Xiao Zicheng 
Published: September 2023

Background: Bladder cancer is a common urological cancer associated high significant morbidity and mortality rates. Immunotherapy has emerged as a promising treatment option, although response rates vary among patients. Glycosylation has been implicated in tumorigenesis and immune regulation. However, our current comprehensive understanding of the role of glycosylation in bladder cancer and its clinical implications is limited.Methods: We constructed a training cohort based on the downloaded TCGA-BLCA dataset, while additional datasets (Xiangya cohort, GSE32894, GSE48075, GSE31684, GSE69795 and E-MTAB-1803) from Xiangya hospital, GEO and ArrayExpress database were obtained and used as validation cohorts. To identify glycosylation-related genes associated with prognosis, univariate Cox regression and LASSO regression were performed. A Cox proportional hazards regression model was then constructed to develop a risk score model. The performance of the risk score was assessed in the training cohort using Kaplan-Meier survival curves and ROC curves, and further validated in multiple validation cohorts.Results: We classified patients in the training cohort into two groups based on glycosylation-related gene expression patterns: Cluster 1 and Cluster 2. Prognostic analysis revealed that Cluster 2 had poorer survival outcomes. Cluster 2 also showed higher levels of immune cell presence in the tumor microenvironment and increased activation in key steps of the cancer immune response cycle. We developed an independent prognostic risk score (p &lt; 0.001) and used it to construct an accurate prognostic prediction nomogram. The high glycosylation risk score group exhibited higher tumor immune cell infiltration, enrichment scores in immune therapy-related pathways, and a tendency towards a basal subtype. Conversely, the low-risk score group had minimal immune cell infiltration and tended to have a luminal subtype. These findings were consistent in our real-world Xiangya cohort.Conclusion: This multi-omics glycosylation score based on these genes reliably confirmed the heterogeneity of bladder cancer tumors, predicted the efficacy of immunotherapy and molecular subtypes, optimizing individual treatment decisions.
The method of determining the forces in the tendon apparatus of human fingers
Authors: Panchenko S. P. , Mametiev A. O. , Naumenko L. Yu. , Chernyshov S. A. , Zub T. O. 
Published: September 2023

Being one of the most functionally loaded systems, the human hand and its anatomical structures are damaged quite often. Thus, injuries to the interphalangeal joints account for up to 60 % of all hand injuries. Post-traumatic arthrosis, contractures with persistent pain syndrome, stiffness and ankylosis of the joints are distinguished among the consequences of hand joint injuries. With the development of the endoprosthesis method, the use of which allows to restore the lost function of the organs of the musculoskeletal system, new opportunities are opening up in the rehabilitation of patients with various injuries of the joints of the hand.
However, when using this method, there are certain complications associated with the wear of the implant, the reaction of the surrounding tissues to the material from which the prosthesis is made, and the design features of endoprostheses.
That is, the success of treatment when using endoprostheses depends to some extent on the design of the implant. It is possible to carry out a primary analysis of the effectiveness of the proposed design of the endoprosthesis with the help of specialized software complexes.
Despite the power of specialized software, building digital models of biological objects and performing calculations is quite a difficult task. In order to carry out a numerical study, in addition to knowing of the geometry of objects and their mechanical properties, it is also necessary to understand the conditions of interaction between the model fragments and the loading scheme.
Aim. Develop a technique for analytical determination of forces in the tendons of the fingers.
Materials and methods. The research was carried out using the provisions and methods of theoretical mechanics and resistance of materials. As a calculation case, this paper proposes to consider the determination of forces in the tendons of the index finger of the right upper limb.
Results. As a result of the performed calculations, analytical expressions were obtained to determine the forces that occur in the flexor tendons of the index finger.
Conclusions. The obtained analytical expressions allow us to estimate the magnitude of forces that occur in the tendons of the fingers. The results of the calculations can be used in the construction of digital models of the fingers and perform numerical studies.
Modern hepatoprotection: a narrative review of existing approaches and prospects for the use of biotechnological drugs
Authors: Hladkykh F. V. , Bielochkina I. V. , Koshurba I. V. , Chyzh M. O. 
Published: September 2023

The prevalence of acute and chronic liver diseases is increasing worldwide, which affects the quality of life and can lead to dangerous, life-threatening complications. Almost 50.0 % of all cases of acute liver failure are caused by drugs, and the overall mortality due to drug-induced liver injury reaches 5.0–11.9 %. In 2020, the hospital incidence of diseases of the digestive organs in Ukraine amounted to 430,593 cases among the adult population, of which 11,976 were fatal.
The aim of the study: to characterize modern approaches to hepatoprotection and prospects of biological therapy based on data from open sources of information.
Materials and methods. Publications were selected based on the PubMed, ClinicalKey Elsevier, Cochrane Library, eBook Business Collection, and Google Scholar databases, which covered information about modern approaches to the treatment of liver diseases.
Results. Patients with chronic liver disease are at risk of extrahepatic complications related to liver cirrhosis and portal hypertension, as well as organ-specific complications of certain liver diseases. These complications can impair the quality of life and increase morbidity and mortality before and after liver transplantation. With chronic damage to the liver by toxic substances, the development of fatty dystrophy against the background of connective tissue changes in the form of nonspecific reactive hepatitis is more often observed. Hepatoprotectors are a pharmacotherapeutic group of heterogeneous drugs that prevent the destruction of cell membranes and stimulate the regeneration of hepatocytes. According to the Anatomical Therapeutic and Chemical classification of drugs (ATC classification), hepatoprotectors take their place in the group of drugs affecting the digestive system and metabolism (A), intended for the treatment of diseases of the liver and biliary tract (A05). One of the promising directions of biological therapy in patients with liver pathology is the use of means obtained from the fetoplacental complex.
Conclusions. Cell therapy in clinically significant volumes is an actual area of modern hepatology. The most promising directions of biological therapy in clinical hepatology are the use of mesenchymal stem cells, agents obtained from the fetoplacental complex, and gene therapy.
Las prácticas socioeconómicas de los sindicatos y la economía obrera. Aportes teórico-metodológicos desde un estudio de caso
Authors: Haidar Julieta 
Published: September 2023

Este trabajo se interesa por las prácticas socioeconómicas del sindicalismo, entendidas como aquellas prácticas orientadas a contribuir a la satisfacción de las necesidades de desarrollo de los trabajadores. El objetivo es poner de relevo y analizar a través de qué prácticas socioeconómicas y en qué medida los sindicatos, en tanto organizadores de los trabajadores para sí, han contribuido a la economía obrera.
En Argentina, las principales prácticas socioeconómicas de los sindicatos son la negociación colectiva y la acción social, las cuales han tenido distintos niveles de complejidad y alcances o efectos sobre las necesidades obreras, según las dinámicas de las relaciones de fuerza con el capital. A partir del estudio de caso del sindicato Luz y Fuerza Capital Federal en dos etapas –una de expansión (1958-1975) y otra de crisis (1976-2002)–, se realizan aportes teórico-metodológicos que dan cuenta de la importancia económica y política de estas prácticas para la lucha de los trabajadores, y para el campo de estudios sobre el sindicalismo.
La evaluación de las prácticas participativas, un desafío inherente para el desarrollo territorial
Authors: Guardamagna Melina , Benedetto Andrea 
Published: September 2023

El presente artículo integra la línea de investigación que se viene desarrollando desde el Centro de Estudios de Innovación Institucional (CEII-UNCuyo/CONICET), a partir de los enfoques del análisis de políticas públicas, la participación ciudadana y el desarrollo territorial. Se parte de la afirmación de que la participación tiene un rol ineludible en los procesos de desarrollo. En consecuencia, el objetivo del trabajo es reflexionar críticamente sobre cuáles deberían ser las dimensiones de un instrumento orientado a evaluar las prácticas participativas implementadas en procesos de políticas, principalmente las orientadas al desarrollo del territorio.
En trabajos anteriores, se avanzó en la definición de un conjunto de dimensiones y criterios que permitieron analizar y evaluar cómo se diseñan, implementan y evalúan los mecanismos de participación ciudadana, así como también la forma en que se trabajan los aportes de política que surgen de los mismos, fundamentalmente en la escala subnacional y local de gobierno. El análisis comparado de diversos casos de América Latina y el Caribe arrojó resultados preliminares que dan origen a la preocupación actual por continuar discutiendo los alcances y limitaciones de las dimensiones y criterios necesarios para evaluar la forma en la que la ciudadanía se hace parte de la gestión de las cuestiones públicas.
ANALISIS IMPLEMENTASI GAME EDUKASI “THE HERO DIPONEGORO” GUNA MENINGKATKAN HASIL BELAJAR SISWA DI MTS. ATTAROQIE MALANG
Authors: Agustina Rini , Chandra Ade 
Published: September 2023

The development of today's technology is impacting on the learning process in schools and also affect the learning material as well as the delivery of a material in the process of teaching and learning activities. Learning is now more attractively designed to encourage and increase student achievement. Learning the Game is one of the new methods are now starting to demand of students, the theme of the lesson give a fresh new look for students to love a subject of study. Curriculum 2013 is a competency-based curriculum. Inside was formulated in an integrated manner the attitude of competence, knowledge and skills that must be mastered learners. Also formulated learning and assessment process required learners to achieve their competencies (Minister of Education and Culture: 2014). Application educational game about the war Diponegoro intended to foster a sense of nationalism to Indonesia country. Where this educational game will be made in accordance with the times and useful as educational deployment solution that can be done anytime and anywhere. Keywords: Educational Games, MTs Attaroqie Malang, PHP CodeIgniter, web base