bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changing Water Chemistry in One Thousand Norwegian Lakes During Three Decades of Cleaner Air and Climate Change
Authors: de Wit Heleen A. , Garmo Øyvind A. , Jackson‐Blake Leah A. , Clayer François , Vogt Rolf D. , Austnes Kari , Kaste Øyvind , Gundersen Cathrine Brecke , Guerrerro Jose Luis , Hindar Atle 
Published: January 2023

AbstractWe present long‐term changes in Norwegian lake water quality across regional gradients in atmospheric pollution, air temperature, hydrology, and vegetation using (a) a national representative lake survey carried out in 1995 and 2019 (ThousandLakes), and (b) an annual lake survey from acid‐sensitive catchments (78 lakes, TrendLakes) from 1990 to 2020. Our analysis encompasses all major chemical constituents, for example, anions and cations, dissolved organic matter (DOM), nutrients, iron (Fe), and silicate (SiO2). During these decades, environmental changes included declines in sulfur (S) and nitrogen (N) deposition, climate warming, and increase in forest biomass. Strong chemical recovery from acidification is found, attributed to large reductions in atmospheric deposition, moderated by catchment processing from land use and climate change. Browning counteracted chemical recovery in some regions, while Ca increased unexpectedly. We suggest that increased weathering, from enhanced terrestrial productivity, is an important driver of increased Ca—substantiated by widespread, substantial increases in SiO2. Light‐ and nutrient‐limitation has become more prevalent, indicated by higher DOM, lower nitrate (NO3), and lower NO3to total phosphorous ratios. Declines in lake NO3 occurred independently of N deposition, suggesting increased catchment N retention, possibly from increased terrestrial productivity. We conclude that decreased air pollution continues to be a dominant driver of long‐term trends in lake chemistry, but climate‐induced increase in terrestrial weathering processes, governed by increased biomass, is likely to have an increasing impact on future lake acidity, nutrient, and light status, that may cascade along the aquatic continuum from rivers to the coast.
Examining Hurricane Ida's Impact on Mental Health: Results From a Quasi‐Experimental Analysis
Authors: Wertis Luke , Runkle Jennifer D. , Sugg Margaret M. , Singh Devyani 
Published: January 2023

AbstractLimited research has evaluated the mental health effects during compounding disasters (e.g., a hurricane occurring during a pandemic), and few studies have examined post‐disaster mental health with alternative data sources like crisis text lines. This study examined changes in crisis help‐seeking for individuals in Louisiana, USA, before and after Hurricane Ida (2021), a storm that co‐occurred during the COVID‐19 pandemic. An interrupted time series analysis and difference‐in‐difference analysis for single and multiple group comparisons were used to examine pre‐and post‐changes in crisis text volume (i.e., any crisis text, substance use, thoughts of suicide, stress/anxiety, and bereavement) among help‐seeking individuals in communities that received US Federal Emergency Management Agency individual and public assistance following a presidential disaster declaration. Results showed a significant increase in crisis texts for any reason, thoughts of suicide, stress/anxiety, and bereavement in the four‐week, three‐month, and four‐month post‐impact period. Findings highlight the need for more mental health support for residents directly impacted by disasters like Hurricane Ida.
Pleistocene Accelerated Exhumation Within the Sumatran Fault: Implications for Late Cenozoic Evolution of Sumatra (Indonesia)
Authors: Wang Yang , Gao Yan , Morley Chris K. , Seagren Erin G. , Qian Xin , Rimando Jeremy M. , Zhang Peizhen , Wang Yuejun 
Published: January 2023

AbstractThe 1,900‐km‐long Sumatran fault plays an important role in accommodating oblique plate motion between the Indo‐Australian and Sunda plates. Although fault geometry, kinematics, and seismic activity are well‐studied, the onset of dextral motion on the Sumatran fault and uplift of adjacent Barisan Mountains is unclear; this hinders an understanding of the late Cenozoic evolution of Sumatra and the forearc region. In this study, we use low‐temperature thermochronology to measure cooling histories of rocks within and outside of the Sumatran fault. An accelerated exhumation within the fault zone began at ∼2 Ma. The Barisan Mountains may have experienced uplift and associated river incision in the late Miocene to Pliocene. The fault systems in the forearc region were inferred to be kinematically linked to the Andaman Sea and Sunda Strait and accommodated early relative plate convergence, then relocated the strike‐slip component of deformation to the Sumatran fault at ∼2 Ma.
The Role of Mesoscale Cloud Morphology in the Shortwave Cloud Feedback
Authors: McCoy Isabel L. , McCoy Daniel T. , Wood Robert , Zuidema Paquita , Bender Frida A.‐M. 
Published: January 2023

AbstractA supervised neural network algorithm is used to categorize near‐global satellite retrievals into three mesoscale cellular convective (MCC) cloud morphology patterns. At constant cloud amount, morphology patterns differ in brightness associated with the amount of optically thin cloud features. Environmentally driven transitions from closed MCC to other morphology patterns, typically accompanied by more optically thin cloud features, are used as a framework to quantify the morphology contribution to the optical depth component of the shortwave cloud feedback. A marine heat wave is used as an out‐of‐sample test of closed MCC occurrence predictions. Morphology shifts in optical depth between 65°S and 65°N under projected environmental changes (i.e., from an abrupt quadrupling of CO2) assuming constant cloud cover contributes between 0.04 and 0.07 W m−2 K−1 (aggregate of 0.06) to the global mean cloud feedback.
The Climate Control of Soil Organic Carbon Dynamics Inferred From Speleothem Radiocarbon Ages
Authors: Xue Gang , Cai Yanjun , Cheng Peng , Lechleitner Franziska A. , Zhang Haiwei , Zheng Yanhong , Wei Yingying , Huang Shouyi , Yang Ling , Cheng Xing , Lu Yanbin , Zhou Jie , Ma Le , Cheng Hai , Edwards R. Lawrence 
Published: January 2023

AbstractThe complexity of processes affecting soil organic carbon (SOC) turnover on spatio‐temporal scales often hinders the extrapolation of results from specific sites to larger scales. This study presents Holocene speleothem U‐Th ages paired with 14C ages of carbonate and dissolved organic carbon (DOC) through three caves located on a north‐south transect through China. The deviations of speleothem 14CDOC ages from the U‐Th ages show clearly spatial variability, and they are positively correlated with mean ages of modern SOC and soil turnover time, suggesting that deviations can be used to infer the SOC turnover. We further demonstrate that slow SOC turnover (large deviation) was associated with weak monsoon (low temperature/less precipitation) on temporal scales. Our findings reveal that climate dominates the speleothem 14CDOC ages and SOC turnover. As global warming likely will intensify, the accelerated turnover of SOC, particularly at higher latitude areas, may partially offset the existing soil carbon stock.
Revisiting the Mechanisms of ENSO Response to Tropical Volcanic Eruptions
Authors: Pausata Francesco S. R. , Zhao Yang , Zanchettin Davide , Caballero Rodrigo , Battisti David S. 
Published: January 2023

AbstractStratospheric volcanic aerosol can have major impacts on global climate. Despite a consensus among studies on an El Niño‐like response in the first or second post‐eruption year, the mechanisms that trigger a change in the state of El Niño‐Southern Oscillation (ENSO) following volcanic eruptions are still debated. Here, we shed light on the processes that govern the ENSO response to tropical volcanic eruptions through a series of sensitivity experiments with an Earth System Model where a uniform stratospheric volcanic aerosol loading is imposed over different parts of the tropics. Three tropical mechanisms are tested: the “ocean dynamical thermostat” (ODT); the cooling of the Maritime Continent; and the cooling of tropical northern Africa (NAFR). We find that the NAFR mechanism plays the largest role, while the ODT mechanism is absent in our simulations as La Niña‐like rather than El‐Niño‐like conditions develop following a uniform radiative forcing over the equatorial Pacific.
Rapid Enhancements of Relativistic Electrons in the Earth's Outer Radiation Belt Caused by the Intense Substorms: A Statistical Study
Authors: Tang ChaoLing , Yang Chang , Chen JingRun , Wang Xu , Ni BinBin , Su ZhengPeng , Zhang JiChun 
Published: January 2023

AbstractUsing the data from Van Allen Probe A and B, we investigate rapid enhancements of relativistic electrons in the Earth's outer radiation belt caused by the intense substorms (AEmax > ∼900 nT) for 29 events from January 2013 to April 2015. These intense substorms may occur during the storm main phase or recovery phase. Based on the different substorm evolution characteristics, the intense substorms are divided into non‐continuous intense substorm activities and continuous intense substorm activities. In this study, we set a criterion for rapid enhancements when the electron phase space densities for μ = 1,096, 2,290, and 3,311 MeV/G increased by more than two times in 9 hr. In the time interval of 9 hr, the local acceleration by chorus waves is the dominant process for accelerating the seed populations (hundred kiloelectron volts) up to MeV energies. Our statistical results show that enhanced chorus waves and seed electrons during the intense substorms are observed in the outer radiation belt. Continuous intense substorm activities can more rapidly (<9 hr) and efficiently accelerate relativistic electrons in the outer radiation belt than non‐continuous intense substorm activities. During the intense substorms, the electric field acceleration could contribute to rapid enhancements of relativistic electrons in the outer radiation belt. Our statistical study suggests that the intense substorms during geomagnetic storms have a significant effect on the rapid variations of relativistic electron dynamics.
Global Application of the Atmospheric River Scale
Authors: Guan Bin , Waliser Duane E. , Ralph F. Martin 
Published: January 2023

AbstractAtmospheric rivers (ARs) are narrow, elongated, transient corridors of enhanced water vapor transport that play important roles in the global water cycle. Increasing scientific and societal interests in ARs prompted the introduction of an AR scale (ranks 1–5, from weak to strong) initially focused on western North America. Aided by a global AR detection algorithm, the current study explores the insights the AR scale can help provide from a global perspective. It is found that AR event count is inversely related to AR rank and peaks in midlatitude oceans. Out of all precipitation occurrences, ARs account for an increasing fraction as the precipitation intensity considered increases. Over the oceans, this fraction is composed of comparable contributions from the five AR ranks, but the contribution of AR 5 is much smaller over land. Higher‐ranked ARs tend to initiate at lower latitudes, terminate at higher latitudes, but follow a less sloped track due to longer zonal displacement. Sensitivity analysis indicates that if ARs are defined using a sole IVT threshold of 250 kg m−1 s−1 globally but with the tropics excluded, the spatiotemporal patterns of key AR event characteristics are largely similar to those described above, except AR events are more frequent by a factor of ∼1.5–2 depending on the AR rank. The results demonstrate the potential of the AR scale in helping evaluate and communicate ARs' influences globally, where the uniform scaling facilitates intercomparisons across different regions and the perception of impacts can be adjusted according to local climatology.
Understanding the Seasonality, Trends, and Controlling Factors of Indian Ocean Acidification Over Distinctive Bio‐Provinces
Authors: Madkaiker Kunal , Valsala Vinu , Sreeush M. G. , Mallissery Anju , Chakraborty Kunal , Deshpande Aditi 
Published: January 2023

AbstractThe Indian Ocean (IO) is witnessing acidification as a direct consequence of the continuous rising of atmospheric CO2 concentration and indirectly due to rapid ocean warming, which disrupts the pH of the surface waters. This study investigates the pH seasonality and trends over various bio‐provinces of the IO and regionally assesses the contribution of each of its controlling factors. Simulations from a global and a regional ocean model coupled with biogeochemical modules were validated with pH measurements over the basin and used to discern the regional response of pH seasonality (1990–2010) and trend (1961–2010) to changes in Sea Surface Temperature (SST), Dissolved Inorganic Carbon (DIC), Total Alkalinity (ALK), and Salinity (S). DIC and SST are significant contributors to the seasonal variability of pH in almost all bio‐provinces. Total acidification in the IO basin was 0.0675 units from 1961 to 2010, with 69.3% contribution from DIC followed by 13.8% contribution from SST. For most of the bio‐provinces, DIC remains a dominant contributor to changing trends in pH except for the Northern Bay of Bengal and Around India (NBoB‐AI) region, wherein the pH trend is dominated by ALK (55.6%) and SST (16.8%). Interdependence of SST and S over ALK is significant in modifying the carbonate chemistry and biogeochemical dynamics of NBoB‐AI and a part of tropical, subtropical IO bio‐provinces. A strong correlation between SST and pH trends infers an increasing risk of acidification in the bio‐provinces with rising SST and points out the need for sustained monitoring of IO pH in such hotspots.
Presence of Access Roads Results in Reduced Growing Season Carbon Uptake in Adjacent Boreal Peatlands
Authors: Saraswati Saraswati , Xu Bin , Strack Maria 
Published: January 2023

AbstractWe conducted a 2‐year study to examine the impacts of resource access roads on carbon (C) exchange in two forested boreal peatlands (a bog and a fen). Along six transects (perpendicular to the road), at 2, 6, and 20 m from the edge of the road on both sides of the road (RI areas), we measured understory CO2 fluxes bi‐weekly from May to August 2016 and 2017 and compared this to measurements at reference areas at least 50 m from the road. Furthermore, we estimated aboveground biomass and net primary productivity of overstory shrubs and trees and combined that with understory fluxes to estimate annual net ecosystem carbon balance, and road‐induced C emissions. Overall, at the bog, the RI areas were sources of C in both 2016 (89.9 g C m−2 y−1) and 2017 (108.9 g C m−2 y−1) while reference areas were sinks. However, at the fen, both RI areas (−744.7, −310.9 g C m−2 y−1 in 2016 and 2017, respectively) and reference areas were sinks of C. Averaged across both peatlands, the estimated road‐induced C losses were ∼7.97 and 7.40 Mg C for each km of the road in 2016 and 2017, respectively. However, areas connected by culverts showed lower road‐associated impact on C emissions. Therefore, we suggest that industries and infrastructure developers align the road parallel to the local water flow direction, when possible, consider the hydrogeological setting during road design to reduce hydrologic impacts, and increase hydrological flows between up‐ and downstream by adequate culverts.
High‐Resolution Sporadic E Layer Observation Based on Ionosonde Using a Cross‐Spectrum Analysis Imaging Technique
Authors: Liu Tongxin , Yang Guobin , Jiang Chunhua 
Published: January 2023

AbstractThe appearance of the sporadic E (Es) layer is an occasional phenomenon in the ionosphere. Limited by range resolution, it is difficult to observe the fine structures and internal evolution processes using existing ionosonde detection techniques. In this study, by analyzing the cross‐spectrum of the echo and the modulation sequence of the transmitted signal, the coherence between frequency components in the signal bandwidth is utilized. Using the Capon spectrum estimation method in the range dimension, the range resolution and use efficiency of the ionosonde are improved. This method does not rely on the joint processing of multifrequency detection data, unlike the frequency domain interferometry technique, maintaining the resulting time resolution. Using this imaging method, observations of the Es layer show that multiple peaks within an intrinsic range bin (3.84 km) can be resolved at a range that is 10‐fold higher (384 m); the multilayer phenomenon inside the Es layer can be clearly imaged in a continuous echo. Semishading between the layers is present. In some cases, the mode of the echo traces can also be directly identified through high‐resolution imaging. Concurrently, observations show that dramatic short‐term evolution processes on the order of seconds inside the Es layer can be captured.
Validation testing of five home blood pressure monitoring devices for the upper arm according to the ISO 81060-2:2018/AMD 1:2020 protocol
Authors: Peprah Yaw Amofa , Lee Ji Young , Persell Stephen D. 
Published: January 2023

AbstractThe accuracy of Omron 10 Series BP7450 (HEM-7342T-Z), Omron Platinum BP5450 (HEM-7343T-Z), Walmart Equate Premium 8000 Series UA-8000WM, Walgreens Premium 15+ WGNBPA-960BT, and CVS Series 800 BP3MW1-4YCVS were assessed in an adult general population compared to a mercury sphygmomanometer standard according to the ISO 81060-2:2018/AMD 1:2020 validation procedure. Omron selected the monitors and included three non-Omron monitors because they were from large retail vendors in the United States and these monitors did not have accessible results from validation testing. The BP7450, N = 85, passed both criteria for the standard. Mean (SD) differences in paired SBP and DBP determinations between the test device and reference were 0.5 (7.7) and 2.5 (6.8) mm Hg. The BP5450, N = 86, passed both criteria. Mean (SD) differences in paired SBP and DBP determinations were 1.9 (7.0) and 3.6 (6.4) mm Hg. The UA-8000WM, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 2.5 (8.0) and 5.1 (6.4) mm Hg. The WGNBPA-240BT, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 7.9 (8.5) and 5.5 (6.7) mm Hg. The BP3MW1-4YCVS, N = 85, did not meet the first criterion for the standard. Mean (SD) differences in paired SBP and DBP determinations were 5.8 (8.7) and 3.1 (5.6) mm Hg. These findings emphasize the importance of verifying the validation status of home blood pressure monitors before use by consumers.
Transcriptional and functional effects of lithium in bipolar disorder iPSC-derived cortical spheroids
Authors: Osete Jordi Requena , Akkouh Ibrahim A. , Ievglevskyi Oleksandr , Vandenberghe Matthieu , de Assis Denis Reis , Ueland Thor , Kondratskaya Elena , Holen Børge , Szabo Attila , Hughes Timothy , Smeland Olav B. , Steen Vidar Martin , Andreassen Ole A. , Djurovic Srdjan 
Published: January 2023

AbstractLithium (Li) is recommended for long-term treatment of bipolar disorder (BD). However, its mechanism of action is still poorly understood. Induced pluripotent stem cell (iPSC)-derived brain organoids have emerged as a powerful tool for modeling BD-related disease mechanisms. We studied the effects of 1 mM Li treatment for 1 month in iPSC-derived human cortical spheroids (hCS) from 10 healthy controls (CTRL) and 11 BD patients (6 Li-responders, Li-R, and 5 Li non-treated, Li-N). At day 180 of differentiation, BD hCS showed smaller size, reduced proportion of neurons, decreased neuronal excitability and reduced neural network activity compared to CTRL hCS. Li rescued excitability of BD hCS neurons by exerting an opposite effect in the two diagnostic groups, increasing excitability in BD hCS and decreasing it in CTRL hCS. We identified 132 Li-associated differentially expressed genes (DEGs), which were overrepresented in sodium ion homeostasis and kidney-related pathways. Moreover, Li regulated secretion of pro-inflammatory cytokines and increased mitochondrial reserve capacity in BD hCS. Through long-term Li treatment of a human 3D brain model, this study partly elucidates the functional and transcriptional mechanisms underlying the clinical effects of Li, such as rescue of neuronal excitability and neuroprotection. Our results also underscore the substantial influence of treatment duration in Li studies. Lastly, this study illustrates the potential of patient iPSC-derived 3D brain models for precision medicine in psychiatry.
Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions
Authors: Jayachandran Priya , Battaglin Francesca , Strelez Carly , Lenz Annika , Algaze Sandra , Soni Shivani , Lo Jae Ho , Yang Yan , Millstein Joshua , Zhang Wu , Shih Jean C. , Lu Janice , Mumenthaler Shannon M. , Spicer Darcy , Neman Josh , Roussos Torres Evanthia T. , Lenz Heinz-Josef 
Published: January 2023

AbstractExploring the relationship between various neurotransmitters and breast cancer cell growth has revealed their likely centrality to improving breast cancer treatment. Neurotransmitters play a key role in breast cancer biology through their effects on the cell cycle, epithelial mesenchymal transition, angiogenesis, inflammation, the tumor microenvironment and other pathways. Neurotransmitters and their receptors are vital to the initiation, progression and drug resistance of cancer and progress in our biological understanding may point the way to lower-cost and lower-risk antitumor therapeutic strategies. This review discusses multiple neurotransmitters in the context of breast cancer. It also discusses risk factors, repurposing of pharmaceuticals impacting neurotransmitter pathways, and the opportunity for better integrated models that encompass exercise, the intestinal microbiome, and other non-pharmacologic considerations. Neurotransmitters’ role in breast cancer should no longer be ignored; it may appear to complicate the molecular picture but the ubiquity of neurotransmitters and their wide-ranging impacts provide an organizing framework upon which further understanding and progress against breast cancer can be based.
NEMO- and RelA-dependent NF-κB signaling promotes small cell lung cancer
Authors: Koerner Lioba , Schmiel Marcel , Yang Tsun-Po , Peifer Martin , Buettner Reinhard , Pasparakis Manolis 
Published: January 2023

AbstractSmall cell lung cancer (SCLC) is an aggressive type of lung cancer driven by combined loss of the tumor suppressors RB1 and TP53. SCLC is highly metastatic and despite good initial response to chemotherapy patients usually relapse, resulting in poor survival. Therefore, better understanding of the mechanisms driving SCLC pathogenesis is required to identify new therapeutic targets. Here we identified a critical role of the IKK/NF-κB signaling pathway in SCLC development. Using a relevant mouse model of SCLC, we found that ablation of NEMO/IKKγ, the regulatory subunit of the IKK complex that is essential for activation of canonical NF-κB signaling, strongly delayed the onset and growth of SCLC resulting in considerably prolonged survival. In addition, ablation of the main NF-κB family member p65/RelA also delayed the onset and growth of SCLC and prolonged survival, albeit to a lesser extent than NEMO. Interestingly, constitutive activation of IKK/NF-κB signaling within the tumor cells did not exacerbate the pathogenesis of SCLC, suggesting that endogenous NF-κB levels are sufficient to fully support tumor development. Moreover, TNFR1 deficiency did not affect the development of SCLC, showing that TNF signaling does not play an important role in this tumor type. Taken together, our results revealed that IKK/NF-κB signaling plays an important role in promoting SCLC, identifying the IKK/NF-κB pathway as a promising therapeutic target.