bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roll Cake Substitusi Tepung Beras Merah Isi Abon Lele Tinggi Kalsium Dan Zat Besi Pencegah Stunting Ibu Hamil
Authors: Kartika Michellia Gemma , Lastariwati Badra , Ratnaningsih Nani 
Published: December 2022

Latar Belakang : Kasus terhambatnya tumbuh kembang secara fisik bayi dan balita karena calon ibu dan ibu hamil yang kekurangan gizi, biasa disebut dengan stunting masih banyak terjadi di Indonesia.
Tujuan : penelitian ini bertujuan untuk mengetahui tingkat kesukaan roll cake susbtitusi tepung beras merah isi abon lele dan kandungan gizi yang terdapat dalam roll cake substitusi tepung beras merah isi abon lele untuk pencegahan penyakit stunting bagi ibu hamil.
Metode: peneltian ini menggunakan R & D dengan model pengembangan 4-D (Four D) terdiri atas 4 tahap utama yaitu: Define (Pendefinisian), Design (Perancangan), Develop (Pengembangan) dan Disseminate (Penyebaran). Pengumpulan data dilakukan dengan uji sensoris (warna, aroma, tekstur, rasa, dan overall) pada produk hasil pengembangan pada tahun 2020, dengan analisis data uji T test berganda.
Hasil : Uji kesukaan terhadap 30 responden menyatakan bahwa perbedaan yang signifikan pada warna dan rasa. Kemudian aroma, tekstur, dan overall menyatakan tidak ada perbedaan yang signifikan. Secara keseluruhan masyarakat menyukai roll cake susbtitusi tepung beras merah isi abon lele. Kandungan gizi roll cake substitusi tepung beras merah isi abon lele : air 27,73%, abu 1,63%, protein 9,22%, lemak 30,28%, karbohidrat 20,62%, energi 392,79%, kalsium 34,45%, dan zat besi 7,06%.
Kesimpulan: Produk roll cake substitusi tepung beras merah isi abon lele disukai panelis, kemudian kandungan zat besi dan kalsium meningkat signifikan. Sehingga dapat digunakan sebagai kudapan tambahan ibu hamil untuk pencegah stunting.
Kata Kunci : Abon lele, roll cake, stunting, tepung beras merah.
Boletín de Noticias "Entre Patologos" de Alconpat Internacional (V4N3, 2022)
Authors:   Alconpat Internacional, Fuchs Hernández Humberto , Zozaya Ortíz Alexia Xiomara ,   Alconpat Internacional, Castro Borges Pedro ,   Alconpat Internacional
Published: December 2022

"Con este boletín, el tercero del año, cerramos un ciclo que fue rico en experiencias y donde Alconpat Internacional continuó demostrando que posee un valioso recurso humano, base fundamental para todo emprendimiento e institución. Muestra de ello es la celebración del XX aniversario de la delegación de Alconpat México con una extraordinaria demostración de organización y esfuerzo. Continuando, el apoyo de nuestra Directiva de Jóvenes y nuestra planta de Socios Colectivos con la realización del 5to Seminario Internacional de Jóvenes Alconpat/Penetron y los Senior Webinar de Alconpat/Holcim y las diversas actividades realizadas por las Alconpats Nacionales. Cerrando etapas en la formación de recursos humanos con los Talleres de Recomendaciones Técnicas de muy alto nivel y aceptación."
Improvement of Coxarthrosis Due to Realignment of Pelvic Retroversion Following Spinal Corrective Surgery
Authors: Suzuki Mayu , Takano Morito , Iida Tsuyoshi , Tsukimura Yasunori , Kaneko Hironori , Hikata Tomohiro 
Published: December 2022

Case:
A 70-year-old woman presented with severe trunk deformity, gait disturbance, and bilateral hip pain. Radiography and magnetic resonance imaging revealed severe spinal kyphosis, bilateral osteoarthritis of the hip joints, and lumbar canal stenosis. A 2-stage corrective surgery for the treatment of spinal kyphosis was performed. Subsequently, the spinopelvic alignment changed remarkably. The spinal symptoms and radiographic parameters improved postoperatively, and bilateral hip pain and range of motion also showed improvement.

Conclusion:
Corrective surgery for the treatment of degenerative spinal kyphosis affected the spinopelvic alignment, and the symptoms of simultaneous coxarthrosis also improved after the corrective surgery.
Interacciones murciélago-flor en el Bosque Seco Tropical del Valle del Cauca, Colombia
Authors: Carvajal Nieto Pamela , Medina Benavides Sara , Bernal-Rivera Andrea , Calvache-Sánchez Cristian , Velásquez-Roa Tatiana 
Published: December 2022

El Bosque seco Tropical (BsT) del Valle del Cauca está sometido a fuertes presiones, sin embargo, es un ecosistema en el que se generan procesos importantes para la conservación de la diversidad biológica, mantenimiento de estructura y función de los ecosistemas, producción de alimentos y economía, como la polinización. Entre los polinizadores destacan los murciélagos, cuyas relaciones han sido poco estudiadas en este contexto, por lo tanto, se buscó identificar las interacciones entre plantas y murciélagos con alto consumo de néctar en diez remanentes de BsT del departamento. Para esto se realizaron capturas de quirópteros nectarívoros-polinívoros y la toma de cargas polínicas en pelaje y heces. Se encontraron seis especies de murciélagos y 77 especies vegetales en interacción, las cuales formaron una red de topología modular, con dos especies animales generalistas que representaron casi el 80 % de las interacciones. El modelamiento de robustez de la red frente a la perdida de especies (extinciones secundarias) indicó que fue robusto a la pérdida de especies especialistas, pero demostró fragilidad a la eliminación de los nodos generalistas, principalmente para murciélagos. Es necesario implementar estrategias de conservación para el BsT que consideren especies de murciélagos polinizadores y plantas nativas que contribuyen al mantenimiento del ecosistema y de los servicios ecosistémicos derivados.
Possibilities of Using of Surface and Subsurface Waves’ Amplitude-Angle Characteristics for Control of Materials with Surface-Hardened Inhomogeneous Layer
Authors: Baev A. R. , Asadchaya M. V. , Mayorov A. I. , Sergeeva O. S. , Delenkovsky N. V. 
Published: December 2022

Improving the efficiency of ultrasonic control of hardened surface layers of metal products with a heterogeneous structure obtained using different technologies is a pressing problem of industrial production. The purpose of this work was to investigate the possibilities of measuring the depth of the surface inhomogeneous layer of steel objects on the basis of the use of amplitude and amplitude-angle characteristics of surface and subsurface transverse waves.The analysis of ultrasonic methods of control of physical and mechanical properties of metals by using surface and subsurface waves and experimentally investigated amplitude-angular characteristics of surface waves, the maximum angle of which increases by 3° at change of dimensionless layer depth hλ from zero to0.82. For the first time, the ratio of normalized amplitudes of surface waves taken at certain angles on theamplitude-angle characteristic curve obtained in the echo mode was proposed to be used as correlating parameters with the depth of the hardened layer. As a result of this research, the possibility of using a phased array transducers to solve the above problems.The effect of the hardened layer depth varying from zero to five in the working frequency range of 1.8– 10 MHz on the peculiarities of the refraction effect (including interference) and dependence of the subsurface wave amplitude on the acoustic base has been studied, making it possible to establish conditions that provide for the determination of the hardened layer depth.Circuit solutions have been offered in order to increase the efficiency of control of properties of the surface layers of metal articles on the basis of utilization of small-aperture transducers and ultrasonic reflectors making it possible to form fields of surface waves of different directional pattern.
Monte Carlo Simulation of Flash Memory Elements’ Electrophysical Parameters
Authors: Zhevnyak O. G. , Borzdov V. M. , Borzdov A. V. , Petlitsky A. N. 
Published: December 2022

Operation of modern flash memory elements is based on electron transport processes in the channel of silicon MOSFETs with floating gate. The aim of this work was calculation of electron mobility and study of the influence of phonon and ionized impurity scattering mechanisms on the mobility, as well as calculation of parasitic tunneling current and channel current in the conductive channel of flash memory element. Numerical simulation during the design stage of flash memory element allows working out guidelines for optimization of device parameters defining its performance and reliability.In the work such electrophysical parameters, characterizing electron transport, as mobility and average electron energy, as well as tunneling current and current in the channel of the flash memory element are studied via the numerical simulation by means of Monte Carlo method. Influence of phonon and ionized impurity scattering processes on electron mobility in the channel has been analyzed. It is shown that in the vicinity of drain region a sufficient decrease of electron mobility defined by phonon scattering processes occurs and the growth of parasitic tunneling current is observed which have a negative influence on device characteristics.The developed simulation program may be used in computer-aided design of flash memory elements for the purpose of their structure optimization and improvement of their electrical characteristics.
Broad One Health Endectocide-based Malaria Intervention in Africa. A Phase III cluster-randomized, open-label, clinical trial to study the safety and efficacy of ivermectin mass drug administration to reduce malaria transmission in two African settings
Authors: Chaccour Carlos , Casellas Aina , Hammann Felix , Ruiz-Castillo Paula , Richardson Mary-Ann , Rabinovich N. Regina 
Published: December 2022

Abstract
Background: Residual malaria transmission is the result of adaptive mosquito behavior that allows malaria vectors to thrive and sustain transmission in the presence of good access to bed nets or insecticide residual spraying. These behaviors include crepuscular and outdoor feeding as well as intermittent feeding upon livestock. Ivermectin is a broadly used antiparasitic drug that kills mosquitoes feeding on a treated subject for a dose-dependent period. Mass drug administration with ivermectin has been proposed as a complementary strategy to reduce malaria transmission.
Methods: A cluster randomized, parallel arm, superiority trial conducted in two settings with distinct eco-epidemiological conditions in East and Southern Africa. There will be three groups, human intervention, consisting of a dose of ivermectin (400 mcg/kg) administered monthly for three months to all the eligible population in the cluster (>15 kg, non-pregnant and no medical contraindication), human and livestock intervention, consisting human treatment as above plus treatment of livestock in the area with a single dose of injectable ivermectin (200 mcg/kg) monthly for three months, and controls, consisting of a dose of albendazole (400 mg) monthly for three months. The main outcome measure will be malaria incidence in a cohort of children under five living in the core of each cluster followed prospectively with monthly RDTs
Discussion: The second site for the implementation of this protocol has changed from Tanzania to Kenya. For simplicity, this summary presents the Mozambique-specific protocol. BOHEMIA will be the first large-scale trial evaluating the impact of ivermectin-only mass drug administration to humans or humans and cattle on local malaria transmission
Trial registration: Clinicaltrials.gov: NCT04966702, Date of registration: July 19, 2021 URL: https://clinicaltrials.gov/ct2/show/NCT04966702
The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia
Authors: Reed R. , Park K. , Waddell B. , Timbers T. , Li C. , Baxi K. , Giacomin R. M. , Leroux M. R. , Carvalho C. E. 
Published: December 2022

Abstract
The conserved Shugoshin (SGO) protein family has essential roles in mediating proper chromosome segregation from yeast to humans. SGO proteins have been implicated in diverse roles in and out of the nucleus; SGO activity inhibits incorrect spindle attachment in the kinetochore, regulates the spindle assembly checkpoint (SAC), and ensures centriole cohesion in the centrosome. These functions involve different microtubule scaffolding structures in the cell. In Caenorhabditis elegans, a species with holocentric chromosomes, SGO-1 is not required for cohesin protection or spindle attachment but appears important for licensing meiotic recombination. Here we provide the first functional evidence that in C. elegans, Shugoshin functions in yet another microtubule-based structure, the primary cilium. We identify the centrosomal and microtubule-regulating transforming acidic coiled-coil protein, TACC/TAC-1, which also localizes to the basal body, as a SGO-1 binding protein. Genetic analyses indicate that TAC-1 activity must be maintained below a threshold at the ciliary base for correct cilia function, and that SGO-1 likely participates in constraining TAC-1 to the basal body by influencing the function of the transition zone ‘ciliary gate’. This research expands our understanding of cellular functions of Shugoshin proteins and contributes to the growing examples of overlap between kinetochore, centrosome and cilia proteomes.
Emergenet: Fast Scalable Pandemic Risk Assessment of Influenza A Strains Circulating In Non-human Hosts
Authors: Chattopadhyay Ishanu , Wu Kevin , Li Jin , Esser-Kahn Aaron 
Published: December 2022

Abstract

Animal influenza viruses emerging into humans have triggered devastating pandemics in the past1–4. Yet, our ability to evaluate the pandemic potential of individual strains that do not yet circulate in humans, remains limited. In this study we introduce the Emergenet, to computationally learn how new variants emerge, shaped by evolutionary constraints using only observed genomic sequences of key viral proteins. Analyzing 187; 294 Haemagglutinnin (HA) and Neuraminidase (NA) sequences from public databases, we estimate the likelihood of specific future mutations, and the numerical odds of specific descendants arising via natural processes. After validating our model to forecast the dominant strain(s) for seasonal flu, with Emergenet-based forecasts significantly outperforming WHO recommendations almost consistently over the past two decades for H1N1/H3N2 subtypes, individually in the Northern/Southern hemispheres (average match-improvement 32:25% over two decades, 69:07% over the last decade, and 81:13% over the pre-COVID-19 five year period for H1N1 HA), we assess the pandemic potential of animal strains not yet known to transmit in humans. While the state-of-the-art Influenza Risk Assessment Tool (IRAT) from the CDC to assess such risk includes time-consuming experimental assays, our calculations take ≈ 6sec=strain, yet strongly correlating with published IRAT scores (correlation: 0:703, p-value: 0:00026). This six orders of magnitude speedup is necessary to exploit current surveillance capacity, and analyze thousands of strains collected annually. Considering 6; 066 wild Influenza A animal viruses sequenced post-2020, we identify risky strains of diverse subtypes, hosts and geo-locations, with six having estimated emergence scores > 6:5. Such scalable risk-ranking can enable preemptive pandemic mitigation, including the targeted inoculation of animal hosts before the first human infection, and outline new public health measures that are potentially effective notwithstanding possible vaccine hesitancy in humans.
Production &amp; Supply of Medical Oxygen: Kerala Model of Pandemic (Covid-19) Management
Authors: Kodavandi Shefeequ Rehman 
Published: December 2022

Abstract
The second wave of COVID-19 severely hit the country, India. Many hospitals, across the country, faced acute shortage of medical oxygen. However, a small state in southern part of India, the State of Kerala, has been highly successful in managing production & supply of medical oxygen. In spite of highest daily confirmed COVID-19 cases & escalated demand for medical oxygen, the State efficiently managed to have sufficient medical oxygen to meet its own demand and supplied excess to needy neighbouring States (Goa, Karnataka and Tamil Nadu). The author tries to identify success factors that having a key role in uninterrupted production & supply of medical oxygen to meet unprecedented increase in demand across the State of Kerala during the pandemic (COVID-19). The study involved a detailed analysis of secondary data. The data was collected from various (offline & online) platforms such as newspapers, news portals, reports, websites etc. The early preparedness, visionary investments (for infrastructure development), effectual monitoring (of production, supply & consumption of medical oxygen), effective communication (among all stakeholders) and continuous coordinated collective efforts (of Oxygen Production Units, the PESO Kerala, the Hospitals, the State Health Department and, the State Government) are the key success factors. The State has been highly successful in managing production & supply of medical oxygen, across the state, during uncertain time of COVID-19 and thus, stood as an exemplary for rest of the country.
Dynamical Analysis of a Damped Harmonic Forced Duffing Oscillator with Time Delay
Authors: Moatimid Galal M. , Amer T. S. , Amer W. S. 
Published: December 2022

Abstract
This paper is concerned with a time-delayed controller of a damped nonlinear excited Duffing oscillator (DO). Since time-delayed techniques have recently been the focus of numerous studies, the topic of this investigation is quite contemporary. Therefore, time delays of position and velocity are utilized to reduce the nonlinear oscillation of the model under consideration. A much supplementary precise approximate solution is achieved using an advanced Homotopy perturbation method (HPM). The temporal variation of this solution is graphed for different amounts of the employed factors. The organization of the model is verified through a comparison between the plots of the estimated solution and the numerical one which is obtained utilizing the fourth order Runge-Kutta technique (RK4). The outcomes show that the improved HPM is appropriate for a variety of damped nonlinear oscillators since it minimizes the error of the solution while increasing the validation variety. Furthermore, it presents a potential model that deals with a diversity of nonlinear problems. The multiple scales homotopy technique is used to achieve an estimated formula for the suggested time-delayed structure. The controlling nonlinear algebraic equation for the amplitude oscillation at the steady state is gained. The effectiveness of the proposed controller, the time delays impact, controller gains, and feedback gains have been investigated. The realized outcomes show that the controller performance is influenced by the total of the product of the control and feedback gains, in addition to the time delays in the control loop. The analytical and numerical calculations reveal that for certain amounts of the control and feedback signal improvement, the suggested controller could completely reduce the system vibrations.
Discovery of novel CSF biomarkers to predict progression in dementia using machine learning
Authors: Gogishvili Dea , Vromen Ellen , Koppes Sascha , Lemstra Afina W , Pijnenburg Yolande , Visser Pieter Jelle , Tijms Betty N , Campo Marta del , Initiative The Alzheimer's Disease Neuroimaging , Abeln Sanne , Teunissen Charlotte E , Vermunt Lisa 
Published: December 2022

Abstract
Providing an accurate prognosis for individual dementia patients remains a challenge since they greatly differ in rates of cognitive decline. In this study, we used machine learning techniques to identify cerebrospinal fluid (CSF) biomarkers that predict the rate of cognitive decline. First, longitudinal follow-up data of 210 dementia patients were used to create fast and slow progression groups. Secondly, we trained random forest classifiers on CSF proteomic profiles and obtained a well-performing prediction model for the progression group (ROC-AUC = 0.82). As a third step, Shapley values and Gini feature importance measures were used to interpret the model performance and identify top biomarker candidates. Lastly, we explored the progression biomarker potential for each of the 20 top candidates in internal sensitivity analyses. TNFRSF4 and TGF β-1 emerged as the top markers, being lower in fast-progressing patients compared to slow-progressing patients. Proteins of which a low concentration was associated with fast progression were enriched for cell signalling and immune response pathways, which could indicate a lack of a protective response in these individuals. None of our top markers stood out as strong individual predictors of subsequent cognitive decline. This could be explained by small effect sizes per protein and biological heterogeneity among dementia patients. Taken together, this study presents a novel progression biomarker identification framework and protein leads for personalised prediction of cognitive decline in dementia.
Assessment of the perception of vertical subjectivity in children born preterm
Authors: Riera-Tur Laura , Lubián-Gutiérrez Manuel , Benavente-Fernández Isabel , Lubián-López Simón , Martín-Mateos Antonio J. , Lechuga-Sancho Alfonso M. 
Published: December 2022

Abstract
Purpose
Children born preterm have increased rates of paediatric mortality and morbidity. Prematurity has been associated with impaired visual perception and visuo-motor integration. The aim of this study was to compare Subjective Visual Vertical Test (SVV) scores in children born preterm compared to children born at term at ages between 7 and 10.
Methods
110 children of 7 to 10 years of age were studied using a mobile application on a smartphone attached to a wall by means of a rotating plate. The SVV test was compared between two groups: a group of 55 children born under 32 weeks of gestational age and another group of 55 children born at term. The SVV results were analysed for comparison with respect to prematurity, sex and age.
Results
We found no significant differences in the SVV study in the comparison between preterm and term children. No significant differences were observed either, regarding sex or age between 7–10 years.
Conclusions
We found no alterations in the perception of vertical subjectivity in children between 7 and 10 years of age, with antecedents of very preterm birth, in accordance with studies performed by posturography.
Regionally high risk increase for precipitation extreme events under global warming
Authors: Martinez-Villalobos Cristian , Neelin J. David 
Published: December 2022

Abstract
Daily precipitation extremes are projected to intensify with increasing moisture under global warming following the Clausius-Clapeyron (CC) relationship at about 7%/oC. However, this increase is not spatially homogeneous. Projections in individual models exhibit regions with substantially larger increases than expected from the CC scaling. Here, we leverage theory and observations of the form of the precipitation probability distribution to substantially improve intermodel agreement in the medium to high precipitation intensity regime, and to interpret projected changes in frequency in the Coupled Model Intercomparison Project Phase 6 (CMIP6). Besides particular regions where models consistently display super-CC behavior, we find substantial occurrence of super-CC behavior within a given latitude band when the multi-model average does not require that the models agree point-wise on location within that band. About 13% of the globe and almost 25% of the tropics (30% for tropical land) display increases exceeding 2CC. Over 40% of tropical land points exceed 1.5CC. Risk-ratio analysis shows that even small increases above CC scaling can have disproportionately large effects in the frequency of the most extreme events. Risk due to regional enhancement of precipitation scale increase by dynamical effects must thus be included in vulnerability assessment even if locations are imprecise.