bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical application value of nomogram model based on clinical and ultrasound features in predicting thyroid C-TI-RADS classification optimization
Authors: liang yu , Xu Tong , Zhang Jing , Song Jun , Huang FuHong , Li Xuan , Fan ErXi , Chen Qin 
Published: April 2023

Abstract
Backgrounds: A nomogram model based on clinical and ultrasound features was constructed to explore its clinical application value in predicting thyroid C-TI-RADS classification optimization. Methods: Clinical data and ultrasound imaging data of 1,234 patients with thyroid nodules collected from January 2021 to February 2022 of Sichuan Provincial People's Hospital were retrospectively analyzed.All patients underwent preoperative thyroid ultrasound examination and retained standard ultrasound images, evaluated the thyroid nodule C-TI-RADS classification, using the postoperative pathological results as the "gold standard". Independent predictors of C-TI-RADS classification optimization were selected by univariate and multivariate logstic regression analysis, and a nomogram prediction model(*C-TI-RADS) was constructed.The internal validation of the model was performed by Bootstrap resampling. ROC curve was drawn to evaluate the discrimination of the model, and calibration curve and decision curve were drawn to evaluate the consistency and clinical practicability of the prediction model. Results: C-TI-RADS classification, size and number of thyroid nodules, abnormal cervical lymph node ultrasonography, sex and age were independent factors for predicting C-TI-RADS classification optimization (all P < 0.05).The C index of the nomogram prediction model(*C-TI-RADS) constructed based on the above factors was 0.790 (95%CI: 0.765–0.815).Under the optimal cut-off value, the sensitivity was 70.8%, the specificity was 74.4%, and the accuracy was 72.2%.The calibration curve and decision curve showed good consistency and clinical practicability of the model. Conclusions: Nomogram model has good accuracy in the prediction of thyroid C-TI-RADS classification optimization, and can assist ultrasound physician to modify C-TI-RADS classification, which has potential clinical application value.
Multiple resonances, fragmented propagation and homogenized attenuation of the beam model coupled with bi-periodic resonators
Authors: Tang Dong , Ran Maohui , Zhang Wei , Ma Zitong , Ding Zihan 
Published: April 2023

Abstract
Wave propagation and attenuation behaviours of beam-resonators coupling model are dominated by the local resonators and the periodicity. Inspired by bi-periodic structures in engineering practice and based on a previous study, beam models coupled with bi-periodic resonators are proposed by introducing a parametric variant resonator into the periodic model. Wavenumber spectrum relation of the bi-periodic coupling system with a parametric variant resonator and several regular resonators is obtained by means of the method of reverberation-ray matrix and solved by numerical techniques. Effects of various parameters of the parametric variant resonator on the wavenumber spectrum characteristics of the bi-periodic models are investigated in numerical examples, which show that the parametric variant resonator results in an additional resonant peak and extra non-local resonant attenuation bands. Bandwidth of the local resonant attenuation band can be broadened by either increasing the translational stiffness or decreasing the mass of the parametric variant resonator. Compared to wavenumber spectrum curves of the beam model coupled with periodic resonators, the introduction of the parametric variant resonator makes the wavenumber spectrum curves of the real part divided into more curved and straight segments in an alternating presentation. The appearance of extra non-local resonant attenuation bands and the decrease of attenuation performance of the original non-local resonant attenuation bands indicates that the attenuation capability of the non-local resonant attenuation bands is homogenized in the frequency domain for the bi-periodic coupling system. The innovative findings and practical suggestions in the whole frequency range could provide potential references for the researchers and engineers in vibration reduction design of bi-periodic structures in engineering practice.
Study on the evaluation of GIS technology on surface water resources in the security intelligence perspective
Authors: Deng Hongwei , Ranchunzhen Ranchunzhen 
Published: April 2023

Abstract
Seeking an efficient and reasonable evaluation method to determine the current evaluation situation of water resources can maximize the protection and utilization of water resources. This paper analyzes the characteristics of previous GIS technology in the evaluation of surface water resources and proposes the establishment of a GIS evaluation optimization model based on security intelligence perspective for the problems of information redundancy and low transmission efficiency of this evaluation method. Firstly, the feasibility and science of constructing a new model under the perspective of security intelligence is discussed, secondly, the development and application of security intelligence theory and the workflow of GIS technology in evaluating surface water resources are reviewed, and finally, the cycle chain of surface water resources evaluation and the optimization model of surface water resources evaluation based on GIS under the perspective of security intelligence are established, and the traditional surface water resources security management system is combined with security intelligence. The security intelligence subsystem and security management subsystem of surface water resources in the intelligence perspective are constructed. The study shows that the surface water resource evaluation model established by GIS technology under the perspective of security intelligence can make up for the deficiencies in information sharing and data standardization of common surface water resource evaluation models, solve the problems of redundancy of massive information and distortion of evaluation results, and provide suggestions for surface water resource evaluation decisions in a certain region or a certain basin.
Nonlinear interactions between vibration modes with vastly different eigenfrequencies
Authors: Shoshani Oriel , Shaw Steven 
Published: April 2023

Abstract
Nonlinear interactions between modes with eigenfrequencies that differ by orders of magnitude are ubiquitous and occur in various fields of physics, ranging from cavity optomechanics to aeroelastic systems. We show that the complex dynamics of these interactions can be distilled into a single generic form, namely, the Stuart-Landau oscillator. We use this model to study lasing in such systems that result in frequency combs that arise from injection locking and frequency pulling of a low-frequency mode that interacts with a blue-detuned high-frequency mode. Our analysis shows that the frequency combs are tunable around both the high and low carrier frequencies. The novelty of our analysis lies in the minimalistic conceptual view that it offers, including an analogy between these complex interactions and a simple mechanical system model and a connection between the injection locking and pulling of the low-frequency mode and the motion of an overdamped particle in a tilted washboard potential. The results are applicable to a wide class of systems and suggest means of generating tunable frequency combs.
Potential health risk of fluoride in groundwater of CKDu endemic areas in Cuttack district of Odisha, India
Authors: MOHANTY SHRADDHA , Nayak Rabindra Kumar , Jena Bandita , Padhan Kshitipati , Dash Prava Kiran , Sahoo Sanjib Kumar , Das Jyotirmayee 
Published: April 2023

Abstract
In Odisha, chronic kidney disease of unknown aetiology (CKDu) has become a major health concern. The disease is particularly prevalent in farming communities and among individuals who rely on groundwater as their primary source of drinking water. Kidney damage is directly associated with excessive fluoride levels in drinking water. The fluoride concentration of 66 typical groundwater samples were analysed throughout 17 gram panchayats in the Narasinghpur block of Cuttack district, Odisha, India, which is considered a hotspot for CKDu. The research area's groundwater fluoride concentration ranged from 0.58 to 4.95 mg/L, with an average of 1.8 mg/L. The content of fluoride in more than 57% of drinking water samples exceeded the WHO recommendation of 1.5 mg/L. The study also assessed the residents' health risks based on exposure pathways through ingestion and dermal contact using the USEPA human health risk assessment model. The values of chronic daily intake (CDI) and Hazard Quotient (HQ) indicated that excessive drinking of fluoride-rich groundwater poses a higher risk of non-carcinogenic health problems to local residents. In the research location, infants and children are more susceptible to the non-carcinogenic health risks of fluoride than adults. This takes place mainly through direct ingestion route where the dominance order of the total hazard index (THI) of population was infants > children > men > women for all sampling locations, suggesting significantly higher risk than the permissible limits (> 1). Based on the results, the area can be classified as a high-risk zone for fluoride-related issues and requires immediate intervention to protect the health and safety of the local population. This study indicates that long-term exposure to fluoride in drinking water may pose harm to human health and disrupt kidney functions. Thus, continuous monitoring and improved management of water supplies in CKDu-affected regions are crucial for determining the contamination load and mitigating the adverse health effects caused by excessive and prolonged exposure to the fluoride found in ground water.
The purpose of weights in excitable brain networks
Authors: Messé Arnaud , Hütt Marc-Thorsten , Hilgetag Claus 
Published: April 2023

Abstract
Nerve fiber networks connecting different brain regions are the structural foundation of brain dynamics and function. Neural connectomes have been frequently described as binary networks, in basic terms of present or absent connections. By contrast, recent approaches have provided more detailed characterizations of connectomes with weighted-strength connections. However, the topological analysis of weighted networks still has methodological limitations. As a consequence, many investigations of neural network are performed on unweighted networks obtained via binarization, and the functional impact of the unweighted versus the weighted neural networks is unclear. Here we show, for the widespread case of excitable dynamics, that the excitation patterns observed in weighted and unweighted networks are nearly identical, if an appropriate threshold is selected. We generalize this observation to different excitable models, and formally predict the network threshold from the intrinsic model features. The network-binarizing capacity of excitable dynamics suggests that neural activity patterns may primarily depend on binary topological properties of neural networks. Moreover, it appears reasonable to assess topological properties of weighted networks with the standard graph-theoretical tools for binarized networks. Our findings have implications for the functional interpretation of connectome data in neuroscience as well as diverse other systems governed by excitable dynamics.
Seasonal and age-related changes in sperm quality of farmed Arctic charr (Salvelinus alpinus)
Authors: Kurta Khrystyna , Jeuthe Henrik , Naboulsi Rakan , Koning Dirk-Jan , Palaiokostas Christos 
Published: April 2023

Abstract
Background
Substantial variation in male fertility is regularly observed in farmed Arctic charr. However, detailed investigations of its fluctuation during a reproductive season and across years are lacking. Furthermore, information about the effect of underlying genetic factors influencing sperm quality is scarce. The current study focused on seasonal and age-related factors that may affect sperm quality characteristics in males reared in natural and delayed photoperiods. Animals were sampled on three occasions for two consecutive years, and sperm quality parameters were recorded using a computer-assisted sperm analysis (CASA) system. Thereafter, high-throughput sequencing technologies were applied, aiming to identify genomic regions related to the variation of sperm quality throughout the reproductive season.
Results
An across-season variation in the recorded sperm quality parameters was evident. Overall, 29% and 42% of males from the natural and delayed spawning groups, respectively, had a highly variable total progressive motility. Males at four years of age showed significantly higher sperm motility and velocities during the early October and November recordings compared to the following year when the same animals were five years of age. On the other hand, the opposite was observed regarding sperm concentration during the last sampling. A genome-wide FST scan detected SNP differentiation among males with high and low variability in total progressive motility (PM) on eight chromosomes (FST > 0.17), Genome wide windows with the highest FST contained SNPs in proximity (within 250 kb up- and downstream distance) to 16 genes with sperm quality biological functions in mammalian species.
Conclusion
Our findings provide a detailed view of seasonal, age-related, and genetic effects on sperm quality and can be used to guide decisions on broodstock selection and hatchery management.
The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance
Authors: Chen Lu , Liu Ao , Wang Qi , Lin Wenhao , Ma Zhiyang , Yang Xiaoqun , Gao Yi , Xu Danfeng 
Published: April 2023

Abstract
Background
Nowadays, the incidence rate of advanced prostate cancer at the first time of diagnosis grows higher in China yearly. At present, androgen deprivation therapy is the standard first-line treatment of advanced prostate cancer. However, after several years of ADT, most patients will inevitably progress to castration-resistant prostate cancer (CRPC). Previous studies mainly focus on Caucasian and very few on East Asian patients.
Methods
In this study, the pre-and post-androgen deprivation therapy tumor samples were collected from five Chinese patients with advanced prostate cancer. The whole-exome sequencing, tumor heterogeneity, and clonal evolution pattern were analyzed.
Results
The results showed that the gene mutation pattern and heterogeneity changed significantly after androgen deprivation therapy. Tumor Mutational Burden (TMB) and Copy Number Alteration (CNA) were substantially reduced in the post-treatment group, but the Mutant-allele tumor heterogeneity (MATH), Socio-Demographic Index (SDI), Intratumor heterogeneity (ITH), and weighted Genome Instability Index (wGII) had no significant difference. According to the clone types and characteristics, the presence of main clones in five pre-and post-treatment samples, the clonal evolution pattern can be further divided into two sub-groups (the Homogeneous origin clonal model or the Heterogeneous origin clonal model). The Progression-free survival of the patients with the “Homogeneous origin clonal model” was shorter than the “Heterogeneous origin clonal model”. The longer PFS might relate to MUC7 and MUC5B mutations repaired. ZNF91 mutation might contribute to resistance to androgen deprivation therapy.
Conclusion
Our findings revealed potential genetic regulators to predict the castration resistance and provide insights into the castration resistance processes in advanced prostate cancer.
Evaluating The Infinium Human MethylationEPIC v2 BeadChip
Authors: Kaur Diljeet , Lee Solmoe , Goldberg David , Spix Nathan J , Hinoue Toshinori , Li Hong-Tao , Dwaraka Varun B , Smith Ryan , Shen Hui , Liang Gangning , Renke Nicole , Laird Peter W , Zhou Wanding 
Published: April 2023

Abstract
Infinium Methylation BeadChips are widely used to profile DNA cytosine modifications in large cohort studies for reasons of cost-effectiveness, accurate quantification, and user-friendly data analysis in characterizing these canonical epigenetic marks. In this work, we conducted a comprehensive evaluation of the updated Infinium MethylationEPIC v2 BeadChip (EPICv2). Our evaluation revealed that EPICv2 offers significant improvements over its predecessors, including expanded enhancer coverage, applicability to diverse ancestry groups, support for low-input DNA down to one nanogram, coverage of existing epigenetic clocks, cell type deconvolution panels, and human trait associations, while maintaining accuracy and reproducibility. Using EPICv2, we were able to identify epigenome and sequence signatures in cell line models of DNMT and SETD2 loss and/or hypomorphism. Furthermore, we provided probe-wise evaluation and annotation to facilitate the use of new features on this array for studying the interplay between somatic mutations and epigenetic landscape in cancer genomics. In conclusion, EPICv2 provides researchers with a valuable tool for studying epigenetic modifications and their role in development and disease.
Multidimensional Molecular Characteristics of Early-Onset Endometrioid Endometrial Carcinoma, And Potential Predictors Of Response To Fertility Sparing Therapy
Authors: Sun Chaoyang , Hu Zhe , Liu Jingbo , Liu Wei , Ning Yan , Fan Junpeng , Li Wenting , Yang Xiaohang , Dou Yingyu , Wang Wei , Peng Wenju , Lu Funian , Zhuang Xucui , Qin Tianyu , Kang Xiaoyan , Wu Zimeng , Feng Chenzhao , Xu Zhiying , Lv Qiaoying , Wang Qian , Wang Chao , Wang Xinyan , Wang Zhiqi , Jiang Jie , Wang Beibei , Mills Gordon , Chen Gang , Chen Xiaojun 
Published: April 2023

Abstract
Endometrial carcinoma (EC) remains a public health concern with a growing incidence particularly in younger women. Women with early-onset endometrioid EC (EEEC) who wish to maintain fertility are a worldwide concern. To illuminate the molecular characteristics of EEEC, we undertook a large-scale proteogenomic study of 222 EECs encompassing 81 EEEC who were 40 or younger. In contrast to late-onset EEC, integrated multi-omics analysis unexpectedly revealed an exposome-related mutational signature to be associated with EEEC leading to EEEC specific CTNNB1 and SIGLEC10 hotspot mutations and downstream protein pathway disturbance. Interestingly, in EEECs SIGLEC10Q144K mutation resulted in aberrant Siglec-10 protein expression and promoted progestin resistance by interacting with ERα. Collectively, our study provides a unique high-quality proteogenomic resource of EEECs while enabling insights into interactions between exposome and genomic susceptibilities for primary prevention and early detection of EEECs. Furthermore, we identified biomarkers for progestin response in EEEC fertility-sparing treatment.
Use of Artificial Intelligence Software Helpful for Regional Anesthesia Education in Self-Reported Questionnaire in Academic Medical Center Setting
Authors: Scholzen Elizabeth A , Schroeder Kristopher M 
Published: April 2023

Abstract
Background: The field of regional ultrasound has changed drastically in the past few decades with the widespread use of ultrasound and improvement of ultrasound images and enhancement of needle visibility on ultrasound. The field is continuing to improve with novel advancements in artificial intelligence software to enhance the field of regional anesthesia education. However, there has been relatively little research on the use of artificial intelligence software on the provision of regional anesthesia education. This study looked to discover the usability of one artificial intelligence software, the NerveBlox® software, in a self-reported questionnaire in an academic medical center among trainees and faculty anesthesiologists.
Methods: 11 anesthesiologists and 25 anesthesiology residents at the University of Wisconsin used the NerveBlox® software to simulate performing supraclavicular and adductor canal nerve blocks on standardized patients and filled out a survey on the utility and functionality of the AI software.
Results: Both faculty and residents rated the NerveBlox® system as helpful in regards to identifying key anatomical structures during the procurement of a regional ultrasound image. Both groups also highly rated the NerveBlox® software as helpful for trainees to improve education in regional ultrasound.
Conclusion: In this small study, both faculty anesthesiologists and anesthesiology residents found the NerveBlox® software to be helpful in both performing regional anesthesia procedures as well as for improving education of regional anesthesia procedures in trainees. Further study with more learners would be helpful to determine the extent of the usefulness of AI software in regional anesthesia education.
Association between α1-adrenoceptor antagonists and delirium: Analysis of the Japanese Adverse Event Report database
Authors: Kotake Kazumasa , Noritake Yumi , Kawakami Yasuhiro 
Published: April 2023

Abstract

Background: Tamsulosin, an α1-adrenoceptor antagonist, may increase the risk of dementia in older men with benign prostatic hyperplasia. An association between α1-adrenoceptor antagonists and delirium has been suggested, but the details are unclear.
Aims: This study investigated the association between α1-adrenoceptor antagonists and delirium in patients with benign prostatic hyperplasia, using the Japanese Adverse Drug Event Report database.
Method: First, disproportionality analysis compared the frequency of delirium in the α1-adrenoceptor antagonists silodosin, tamsulosin, and naftopidil. Next, multivariate logistic analysis was performed to examine the association between delirium and α1-adrenoceptor antagonists where disproportionality was detected.
Results: A disproportionality in delirium was observed in patients who received tamsulosin (reporting odds ratio 1.85, 95% confidence interval 1.38–2.44, P < 0.01) and naftopidil (reporting odds ratio 2.23, 95% confidence interval 1.45–3.28, P < 0.01). Multivariate logistic analysis revealed that in addition to previously reported risk factors for delirium, delirium in patients who received tamsulosin was significantly increased with concomitant use of anticholinergics (odds ratio 2.73, 95% confidence interval 1.41–5.29, P < 0.01) and delirium in patients who received naftopidil was significantly increased with concomitant use of β3 adrenoceptor agonists (odds ratio 4.19, 95% confidence interval 1.66–10.6, P < 0.01).
Conclusion: We found that concomitant use of anticholinergic or β3 adrenoceptor agonistsused to treat overactive bladder were strongly associated with delirium. Therefore, confirming the medical history and concomitant medications of patients who receive tamsulosin or naftopidil and providing preventive interventions for delirium may contribute to improved patient outcomes.