bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bacterial predation of a fungal wheat pathogen: Prelude to experimental evolution of enhanced biocontrol agents
Authors: Eisner Sabrina A. , Fiegna Francesca , McDonald Bruce A. , Velicer Gregory J. 
Published: February 2023

AbstractResearch to identify appropriate biological agents for controlling pathogens might exploit experimental evolution to select for enhanced antagonism against pathogens. We developed an experimental regime facilitating this approach, featuring the bacterial broad‐spectrum predator Myxococcus xanthus and the fungal wheat pathogen Zymoseptoria tritici. We demonstrate that Z. tritici, a major cause of crop loss and fungicide use worldwide, both fuels growth of and is killed by M. xanthus on wheat straw, a probable source of seedling infection. M. xanthus was found capable of growth on moistened straw alone, unaided by Z. tritici, in a manner dependent on both M. xanthus initial density and on how long straw was moistened before M. xanthus inoculation. Such growth of non‐cellulolytic myxobacteria on plant detritus may have implications for understanding their roles in nutrient cycling. However, straw with Z. tritici was found to fuel greater M. xanthus growth than straw alone under many conditions. After shorter moistening periods, growth by low‐density M. xanthus populations was found to be fully dependent on Z. tritici. Such pathogen‐dependent M. xanthus populations could be sustained with population replacement over five 1‐week growth cycles, indicating the feasibility of conducting long‐term experimental evolution with this system. Furthermore, M. xanthus was found to kill majorities of Z. tritici populations on both buffered agar and straw. Our results suggest that myxobacteria may serve as effective biocontrol agents of Z. tritici and are amenable to long‐term experimental selection for enhanced killing of this pathogen, an approach broadly applicable to many potential biocontrol agents and target pathogens.
Aducanumab for the treatment of Alzheimer's disease: a systematic review
Authors: Rahman Afroza , Hossen Md Anwar , Chowdhury Mirza Farhana Iqbal , Bari Sadia , Tamanna Nuzhat , Sultana Syeda Salima , Haque Sharar Naiarin , Al Masud Abdullah , Saif‐Ur‐Rahman K.M. 
Published: February 2023

Aducanumab is a novel disease‐modifying anti‐amyloid‐beta (Aβ) human monoclonal antibody specifically targeted to the pathophysiology of Alzheimer's disease (AD). It was granted for treating AD in June 2021 by the United States Food and Drug Administration. We systematically analyzed available trials to evaluate the efficacy and safety of aducanumab treating AD. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analysis) guidelines. We conducted an extensive literature search using the electronic databases MEDLINE through PubMed, EMBASE, Cochrane, Web of Science, and Scopus for suitable studies on aducanumab. We considered human clinical trials of aducanumab, assessing its efficacy and adverse effects in treating AD, excluding any experimental animal studies. We included three randomised controlled trials. Studies reported that aducanumab reduced brain amyloid‐beta plaques in a time‐ and dose‐dependent manner (dose–response, P < 0.05) and a slowed decline in cognition (22% reduction) in the high‐dose treated group, difference of −0.39 versus placebo in Clinical Dementia Rating Scale Sum Boxes (95% CI, −0.69 to −0.09; P = 0.012) along with a reduced amyloid positron emission tomography standard uptake value ratio score (P < 0.001) and plasma p181‐tau (phosphorylated tau) level. Amyloid‐related imaging abnormality was reported as a serious adverse event and was profound in high‐dose treated group (425/1029 in 10 mg/kg). Aducanumab has been reported to affect two main pathophysiologic hallmarks (Aβ and tau) of AD. We suggest future studies addressing aducanumab's efficacy and safety to confirm that the benefit of this drug outweighs the risk.
Collaborative Recall and the Construction of Collective Memory Organization: The Impact of Group Structure
Authors: Greeley Garrett D. , Chan Vanessa , Choi Hae‐Yoon , Rajaram Suparna 
Published: February 2023

AbstractCollaborative recall synchronizes downstream individual retrieval processes, giving rise to collective organization. However, little is known about whether particular stimulus features (e.g., semantic relatedness) are necessary for constructing collective organization and how group dynamics (e.g., reconfiguration) moderates it. We leveraged novel quantitative measures and a rich dataset reported in recent articles to address, (a) whether collective organization emerges even for semantically unrelated material and (b) how group reconfiguration—changing partners from one recall to the next—influences collective organization. Participants studied unrelated words and completed three consecutive recalls in one of three conditions: Always recalling individually (III), collaborating with the same partners twice before recalling alone (CCI), or collaborating with different group members during two initial recalls, before recalling alone (CRI). Collective organization increased significantly following any collaboration (CCI or CRI), relative to “groups” who never collaborated (III). Interestingly, collaborating repeatedly with the same partners (CCI) did not increase collective organization compared to reconfigured groups, irrespective of the reference group structure (from Recall 1 or 2). Individuals, however, did tend to base their final individual retrieval on the most recent group recall. We discuss how the fundamental processes that underlie dynamic social interactions align the cognitive processes of many, laying the foundation for other collective phenomena, including shared biases, attitudes, and beliefs.
Spanier–Whitehead duality for topological coHochschild homology
Authors: Bayindir Haldun Özgör , Péroux Maximilien 
Published: February 2023

AbstractIn this work, we compute the topological coHochschild homology (coTHH) of interesting coalgebras such as the Steenrod algebra spectrum. For this, we start by extending the Hess–Shipley definition of coTHH to ‐categories, following the Nikolaus–Scholze approach to topological Hochschild homology (THH). Furthermore, we prove that coTHH of what we call quasi‐proper coalgebras can be obtained from THH via Spanier–Whitehead duality which provides further insight into coTHH and its relationship to THH.
The Effect of Menstrual-Cycle Phase on Immune Responses to a 5-km Cycling Time Trial: An Exploratory Study
Authors: Hicks Kirsty M. , Orange Samuel T. , Dulson Deb , Ansdell Paul , Todryk Stephen , Gilbert Stephen , Saxton John M. 
Published: February 2023

Purpose: Exercise has transient effects on the immune system that could influence infection risk and tissue recovery after exercise. Little is known about how the menstrual cycle interacts with the immune responses to acute exercise. This exploratory study sought to evaluate the effect of menstrual-cycle phase on peripheral blood mononuclear cell counts before and immediately after a bout of intense aerobic exercise. Methods: Seven naturally menstruating women (age: 27 [3] y) completed three 5-km cycling time trials coinciding with the early-follicular, late-follicular, and mid-luteal stage, confirmed by hormonal measurement. Venous blood samples were taken and examined for the presence of immune cell types using flow cytometry. Results: Reductions in circulating CCR7+CD45RA+ naïve CD4+ T cells, CD4+CD25+ regulatory T cells, and CD56+CD57+ natural killer cells observed during the early-follicular phase were attenuated when exercise was performed during the late-follicular phase. Similarly, reductions in circulating CD56+CD57+ natural killer cells and CD14+TLR4+ monocytes following exercise in the early-follicular phase were abolished when exercise was performed in the midluteal phase. Conclusions: These preliminary findings indicate that the effect of acute high-intensity exercise on immune-cell mobilization and activation varies across the menstrual cycle, potentially impacting the anti-inflammatory effects of regulatory T cells and the cell-mediated effects of both natural killer CD57+ cells and monocytes expressing TLR4.
Groundwater level monitoring of Danish chalk and limestone aquifers to survey trends in quantitative status and groundwater resources
Authors: Henriksen H. J. , Nilsson B. , Ditlefsen C. , Troldborg L. , Thorling L. 
Published: February 2023

Abstract
Chalk and limestone aquifers contribute one-third of the drinking water supply in Denmark, and one-sixth of that national groundwater resource is assessed as having a ‘Poor’ status in terms of the quantitative Water Framework Directive due to intensive abstraction. This paper describes the national groundwater level monitoring network with regard to the following three applications: (1) when used for the annual surveying and reporting of groundwater resources and impacts from climate and groundwater abstraction; (2) as part of real-time monitoring and modelling for daily and seasonal forecasting; and (3) for tracking long-term climate change impacts on groundwater levels. Groundwater level monitoring provides a particularly important indicator of abstraction pressure and sustainable balance compared with recharge.
Many larger chalk and limestone groundwater bodies in Denmark are only monitored by local water companies and not represented in the national groundwater level network. This raises the concern that current national groundwater level monitoring does not fully support integrated modelling and assessment purposes for chalk and limestone groundwater bodies. This also implies that, for tracking long-term climate change and anthropogenic impacts on groundwater levels, the national groundwater monitoring network especially lacks long-term records with complete 30-year time-series for many intensively exploited large chalk and limestone aquifers.
TriCache: A User-Transparent Block Cache Enabling High-Performance Out-of-Core Processing with In-Memory Programs
Authors: Feng Guanyu , Cao Huanqi , Zhu Xiaowei , Yu Bowen , Wang Yuanwei , Ma Zixuan , Chen Shengqi , Chen Wenguang 
Published: February 2023

Out-of-core systems rely on high-performance cache sub-systems to reduce the number of I/O operations. Although the page cache in modern operating systems enables transparent access to memory and storage devices, it suffers from efficiency and scalability issues on cache misses, forcing out-of-core systems to design and implement their own cache components, which is a non-trivial task.
This study proposes TriCache, a cache mechanism that enables in-memory programs to efficiently process out-of-core datasets without requiring any code rewrite. It provides a virtual memory interface on top of the conventional block interface to simultaneously achieve user transparency and sufficient out-of-core performance. A multi-level block cache design is proposed to address the challenge of per-access address translations required by a memory interface. It can exploit spatial and temporal localities in memory or storage accesses to render storage-to-memory address translation and page-level concurrency control adequately efficient for the virtual memory interface.
Our evaluation shows that in-memory systems operating on top of TriCache can outperform Linux OS page cache by more than one order of magnitude, and can deliver performance comparable to or even better than that of corresponding counterparts designed specifically for out-of-core scenarios.
A Systematic Review and Multilevel Regression Analysis Reveals the Comorbidity Prevalence in Cancer
Authors: Vrinzen Cilla E.J. , Delfgou Linn , Stadhouders Niek , Hermens Rosella P.M.G. , Merkx Matthias A.W. , Bloemendal Haiko J. , Jeurissen Patrick P.T. 
Published: February 2023

AbstractComorbidities can have major implications for cancer care, as they might impact the timing of cancer diagnosis, compromise optimal care, affect treatment outcomes, and increase healthcare costs. Thus, it is important to comprehensively evaluate cancer comorbidities and examine trends over time. Here, we performed a systematic literature review on the prevalence and types of comorbidities for the five most common forms of cancer. Observational studies from Organisation for Economic Co-operation and Development countries published between 1990 and 2020 in English or Dutch that used routinely collected data from a representative population were included. The search yielded 3,070 articles, of which, 161 were eligible for data analyses. Multilevel analyses were performed to evaluate determinants of variation in comorbidity prevalence and trends over time. The weighted average comorbidity prevalence was 33.4%, and comorbidities were the most common in lung cancer (46.7%) and colorectal cancer (40.0%), followed by prostate cancer (28.5%), melanoma cancer (28.3%), and breast cancer (22.4%). The most common types of comorbidities were hypertension (29.7%), pulmonary diseases (15.9%), and diabetes (13.5%). After adjusting for gender, type of comorbidity index, age, data source (patient records vs. claims), and country, a significant increase in comorbidities of 0.54% per year was observed. Overall, a large and increasing proportion of the oncologic population is dealing with comorbidities, which could be used to inform and adapt treatment options to improve health outcomes and reduce healthcare costs.Significance:Comorbidities are frequent and increasing in patients with cancer, emphasizing the importance of exploring optimal ways for uniform comorbidity registration and incorporating comorbidity management into cancer care.
Current Status and Challenges of Vaccination Therapy for Glioblastoma
Authors: Hosseinalizadeh Hamed , Rahmati Mohammad , Ebrahimi Ammar , O'Connor Roddy S. 
Published: February 2023

AbstractGlioblastoma (GBM), also known as grade IV astrocytoma, is the most common and deadly type of central nervous system malignancy in adults. Despite significant breakthroughs in current GBM treatments such as surgery, radiotherapy, and chemotherapy, the prognosis for late-stage glioblastoma remains bleak due to tumor recurrence following surgical resection. The poor prognosis highlights the evident and pressing need for more efficient and targeted treatment. Vaccination has successfully treated patients with advanced colorectal and lung cancer. Therefore, the potential value of using tumor vaccines in treating glioblastoma is increasingly discussed as a monotherapy or in combination with other cellular immunotherapies. Cancer vaccination includes both passive administration of monoclonal antibodies and active vaccination procedures to activate, boost, or bias antitumor immunity against cancer cells. This article focuses on active immunotherapy with peptide, genetic (DNA, mRNA), and cell-based vaccines in treating GBM and reviews the various treatment approaches currently being tested. Although the ease of synthesis, relative safety, and ability to elicit tumor-specific immune responses have made these vaccines an invaluable tool for cancer treatment, more extensive cohort studies and better guidelines are needed to improve the efficacy of these vaccines in anti-GBM therapy.
Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ
Authors: Sun Yu , Stenson Kate , Mohan Maradumane L. , Gupta Manveen K. , Wanner Nick , Asosingh Kewal , Erzurum Serpil , Naga Prasad Sathyamangla V. 
Published: February 2023

Background:
Impaired beta-adrenergic receptor (β1 and β2AR) function following hypoxia underlies ischemic heart failure/stroke. Activation of PI3Kγ (phosphoinositide 3-kinase γ) by beta-adrenergic receptor leads to feedback regulation of the receptor by hindering beta-adrenergic receptor dephosphorylation through inhibition of PP2A (protein phosphatase 2A). However, little is known about PI3Kγ feedback mechanism in regulating hypoxia-mediated β1 and β2AR dysfunction and cardiac remodeling.

Methods:
Human embryonic kidney 293 cells or mouse adult cardiomyocytes and C57BL/6 (WT) or PI3Kγ knockout (KO) mice were subjected to hypoxia. Cardiac plasma membranes and endosomes were isolated and evaluated for β1 and β2AR density and function, PI3Kγ activity and β1 and β2AR-associated PP2A activity. Metabolic labeling was performed to assess β1 and β2AR phosphorylation and epinephrine/norepinephrine levels measured post-hypoxia.

Results:
Hypoxia increased β1 and β2AR phosphorylation, reduced cAMP, and led to endosomal accumulation of phosphorylated β2ARs in human embryonic kidney 293 cells and WT cardiomyocytes. Acute hypoxia in WT mice resulted in cardiac remodeling and loss of adenylyl cyclase activity associated with increased β1 and β2AR phosphorylation. This was agonist-independent as plasma and cardiac epinephrine and norepinephrine levels were unaltered. Unexpectedly, PI3Kγ activity was selectively increased in the endosomes of human embryonic kidney 293 cells and WT hearts post-hypoxia. Endosomal β1- and β2AR-associated PP2A activity was inhibited upon hypoxia in human embryonic kidney 293 cells and WT hearts showing regulation of beta-adrenergic receptors by PI3Kγ. This was accompanied with phosphorylation of endogenous inhibitor of protein phosphatase 2A whose phosphorylation by PI3Kγ inhibits PP2A. Increased β1 and β2AR-associated PP2A activity, decreased beta-adrenergic receptor phosphorylation, and normalized cardiac function was observed in PI3Kγ KO mice despite hypoxia. Compared to WT, PI3Kγ KO mice had preserved cardiac response to challenge with β1AR-selective agonist dobutamine post-hypoxia.

Conclusions:
Agonist-independent activation of PI3Kγ underlies hypoxia sensing as its ablation leads to reduction in β1- and β2AR phosphorylation and amelioration of cardiac dysfunction.
Acute Microbleeds and Microinfarcts Within the Perihematomal Area After Intracerebral Hemorrhage
Authors: Puy Laurent , Rauch Antoine , Deramecourt Vincent , Cordonnier Charlotte , Bérézowski Vincent 
Published: February 2023

Background:
To further our understanding of the pathophysiology of spontaneous intracerebral hemorrhage (ICH) and related injury, we provided a postmortem neuropathological examination of acute microvascular lesions (microbleeds and microinfarcts) within the perihematomal area.

Methods:
We included all consecutive cases (2005–2019) from the Lille University Hospital brain bank of ICH patients who died within the first month. Paraffin-embedded tissue sections from the perihematomal area were processed for several stainings and immunolabelings to investigate the presence of acute microbleeds and microinfarcts in the perihematomal area and to characterize surrounding neuronal and systemic inflammatory reaction (macrophages and neutrophils).

Results:
We included 14 ICH cases (median age, 78 years; 10 females). Acute microbleeds were observed in the perihematomal area in 12/14 patients (86%, ranging from 1 through >10) and microinfarcts in 5/14 (36%, ranging from 1 through 4). Microbleeds were observed whatever the delay from ICH onset to death was, while most cases with acute microinfarcts were observed between day 3 and day 7 (n=3/5). Both lesions were characterized by an abundant accumulation of systemic inflammatory cells and necrotic areas.

Conclusions:
Acute microbleeds and microinfarcts might contribute to the propagation of secondary brain tissue damages after ICH. Our examinations also question the potential role of massive systemic inflammatory cells recruitment in the genesis of these microvascular injuries.
Who influences policy labs in the European Union? A social network approach
Authors: Romero-Frías Esteban , Torres-Salinas Daniel , Arroyo-Machado Wenceslao 
Published: February 2023

Abstract
The growing importance of public innovation has been manifested through the creation of policy labs: spaces for policy experimentation and innovation that work for or within a government entity. The rise of this phenomenon in Europe was evidenced by the creation of a policy lab by the European Commission (EC) in 2016 and the publication by the EC of a report identifying policy labs and their influencers in Europe. Public innovation is increasingly based on national and international networks, giving rise to complex ecosystems involving participation by multiple actors from countries with different administrative approaches. Our study uses social network analysis of these labs’ Twitter profile data to map the European Union’s (EU) public innovation ecosystem and identify the major influencers. Policy labs and their influencers are analyzed by administration style by using a large geographical database. The results reveal a complex global network of influencers and a strong predominance of the Anglo-Saxon administration style. From an EU perspective, our systematic analysis of influence is particularly important in the post-Brexit context, helping to foster a genuine public innovation ecosystem that is both autonomous and interconnected with the aim of facing challenges such as the Sustainable Development Agenda and COVID-19 crisis recovery.
Effects of the nutrition education intervention on food security, anthropometry, and body composition in women: A randomized controlled trial
Authors: Ebadi-Vanestanagh Marziyeh , Molani-Gol Roghayeh , Alizadeh Mohammad 
Published: February 2023

Background Food insecurity as a social determinant of health is associated with adverse physical health outcomes such as obesity. Aim This study aimed to evaluate the effects of nutrition education intervention based on the transtheoretical model (TTM) on food security, anthropometry, and body composition status. Methods In this randomized controlled trial, an intervention was conducted over months (five weeks) using the TTM among 160 women aged 19–64 years. Food security status, anthropometry, and body composition were determined three times: at baseline, three months, and six months after the intervention. Results In the intervention group, food insecurity significantly decreased before, immediately after, and six months after the intervention, these changes were significant in follow-up time and treatment effect. After six months of follow-up, the intervention group significantly decreased weight (−1.29 kg), body mass index (−0.54), and waist circumference (−3.48 cm). Although differences between the two groups were not statistically significant except in the interaction between follow-up time and intervention groups. Also, the mean of fat mass and total body water decreased in the intervention group and differences between the two groups were statistically significant in follow-up time ( p < 0.001 and p = 0.01, respectively) and interaction between follow-up time and intervention group ( p < 0.001 and p = 0.005, respectively). Conclusion In the current study, the findings of a six-month TTM-based intervention among women were positive that revealed to be a strategy that may improve anthropometric and nutritional status. Therefore, government programs that offer nutrition counseling should be prioritized to help the population to improve their eating habits.