bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric severe COVID – 19 and MIS-C in the Brazilian Amazon: independent risk factors to mortality
Authors: Farias Emmerson Carlos Franco , Pavão Manoel J.C. , Sales Susan C.D. , Nascimento Luciana M.P.P. , Pavão Dalila C.A. , Pinheiro Ana P. S. , Pinheiro Andreza H.O. , Alves Marília C.B. , Ferraro Kíssila M.M.M , Aires Larisse F.Q. , Dias Luana G. , Machado Mayara M.M. , S Michaelle J.D. , Gomes Rafaella R. , Moraes Sara M.P. , Galvão Gabriella M. , Sousa Adriana MB , Pontes Gabriela C.L. , Carvalho Railana D.F.P. , Silva Cristiane T.C. , Diniz Bruna da C. G. , Saraty Salma B. , Mello Mary L.F. , Carvalho Patricia B. , Braga Renata B. , Harada Kathia O. , Terreri Maria T. , Clemente Gleice , Chermont Aurimery G. , JUSTINO MARIA C.A. , Lima Miriam R.C. , de Almeida Kellen F.S. 
Published: March 2023

Abstract
Purpose: SARS-CoV-2 infection in children is usually asymptomatic/mild. However, some patients may develop critical forms. Our aim was to evaluate the independent risk factors associated to in-hospital mortality in children with critical disease related to SARS-CoV-2.
Methods: This is multicenter prospective cohort included critically ill children (1 month/18 years of age), with confirmed critical disease related to SARS-CoV-2 admitted to three tertiary Pediatric Intensive Care Units (PICU) in Brazilian Amazon, between April 2020/July 2022. Main outcome was in-hospital mortality. The independent risk factors associated with mortality were evaluated with a multivariable Cox proportional regression.
Results: 208 patients were assessed. Median age was 33 months and median follow-up was 277 days (range, 2-759). Death occurred in 37 (17.8%) patients with a median follow-up of 7 (4-13) days. Most non-survivors had at least one comorbidity - 34 (91.9%). Substantial clinical features, laboratory and ventilatory parameters were associated with mortality. Independent risk factors for mortality were underweight status (HR= 6.64, p=0.01), vasoactive inotropic score (VIS) > 84 (HR=4.76, p=0.05), acute respiratory distress syndrome (HR=8.63, p=0.02) and erythrocyte sedimentation rate (ESR) >18 mm/hour (HR=3.95, p=0.03).
Conclusions: This study of critically ill patients with COVID-19 and MIS-C from the Brazilian Amazon showed a high mortality rate. The risk of death was higher for underweight individuals, those with higher levels of VIS and ESR, presence of ARDS. The majority of deaths occurred within 10 days of hospitalization, highlighting the importance of prompt recognition in regard to these patients.
Parietal epithelial cells differentiate into podocytes dependent on ROS-Nrf2-Brg1 signaling
Authors: Wang Minzhou , Lu Jiayue , Xie Kewei , Lu Renhua , Min Lulin , Song Ahui , Zhao Bingru , Wu Wangshu , Gu Leyi 
Published: March 2023

Abstract
The injury of glomerular visceral epithelial cells (podocytes) is the initial target in FSGS. However, podocytes are terminally differentiated cells in the glomerular and can hardly regenerate. Recent studies have shown that parietal epithelial cells (PECs) are potential stem cells in the glomerulus, which are able to differentiate into podocytes and participate in the regeneration and repair of podocytes after injury. Whereas the specific mechanism of regulation of PECs differentiating to podocytes remains unclear. Here, we found several podocytes also expressed PECs marker claudin-1 in ADR nephropathy mice. Podocyte markers WT-1, FOXC1, synaptopodin and podocin were upregulated after PECs differentiating into podocytes in vitro. After inhibition of total and mitochondrial ROS, PECs differentiation into podocytes decreased. Further studies showed that the expression of ROS related molecule Nrf2 and its target protein Brg1 increased after PECs were induced, while inhibition of Nrf2 or Brg1 reduced PECs transdifferentiation, and the overexpression of Nrf2 or Brg1 showed the opposite result. Brg1 directly regulates WT-1 transcription in PECs. We also observed an increase in WT1 positive cells at ADR damage in mice with PAX8 conditional overexpression of NRF2. We conclude when PECs are stimulated by extracellular signals, the high expression of WT-1 transcription factor in podocytes can be regulated by ROS-Nrf2-Brg1 signal, thus differentiating into podocytes.
How the behavior of tribocorrosion of biocomposites containing mollusc shell particles is affected by potential in the presence of bovine serum solution
Authors: sidia besma , BENSALAH walid 
Published: March 2023

Abstract
The study used a reciprocating tribocorrosimeter to perform tribocorrosion tests on a composite material composed of different weight percentages of MS (0, 5, 10, and 15 wt% MS). The open circuit potential of the Ti6Al4V pin in contact with the biocomposite was examined, and the impact of MS loading on the coefficient of friction and wear rate was analyzed in the presence of bovine serum. The results indicated that the optimum MS content was approximately 5 wt%. Finally, the study proposed a wear scenario for the MS loading when exposed to bovine serum solution.
Hybrid cross-laminated timber prepared with larch and OSB
Authors: LI Ming-yue , Hai-qing REN 
Published: March 2023

Abstract
This study explores the application of oriented strand board (OSB) to hybrid cross-laminated timber (HCLT). OSB and larch were used to prepare hybrid forms of HCLT for annlysis. Firstly, the effect of OSB surface treatment on the properties of the bonding line between materials was studied, including the surface properties of OSB before and after surface treatment. Block shear testing and cyclic delamination testing were used to study the bonding properties. The test results showed that suitable sanding can enhance the bonding performance. The optimal surface treatment process for OSB in this paper was found to be sanding at 0.2 mm depth. Secondly two layups of HCLT were prepared by combining OSB with larch, and the interlaminar shear strength was assessed in both the major and minor strength directions using a three-point bending test. The results showed that, due to the low density and mechanical properties of OSB, its application in HCLT as perpendicular layer is not a favorable choice, because it can not avoid the rolling shear failure in perpendicular layer, and it also reduces the interlaminar shear strength of HCLT in the minor strength direction. However, the interlaminar shear strength decreases in both the major and minor strength directions when OSB was used as the parallel layer, and larch was used as the perpendicular layer. Consequently, this improved the two-way carrying capacity of the HCLT plate.
An Energy Efficient WSN-Assisted IoT Network using Heterogeneous Dynamic Multi-hop Cluster-based Routing Protocol
Authors: Elmonser Malika , Chikha Haithem Ben , Attia Rabah 
Published: March 2023

Abstract
Heterogeneous Wireless sensor networks (WSNs) deploy hundreds to thousands of low-cost sensors in their area detection, and these heterogeneous nodes present the main parts of the Internet of Things (IoT) network. Sensor node parameters, such as initial energy and data processing capability largely influence the network's lifetime in WSN-assisted IoT. Despite the success of various hierarchical clustering strategies dedicated to WSNs, their widespread deployment makes the search for an optimal network routing protocol an open challenge. When every node starts off with the same energy, homogeneous networks are what most hierarchical protocols have in mind. Some protocols have considered heterogeneous networks, where sensor nodes have more power and traffic than others. The network lifetime can be extended as a result. In order to increase energy conservation and extend network lifetime, this research present a Heterogeneous Dynamic Multi-Hop Low-Energy Adaptive Clustering Hierarchy (HDM-LEACH) protocol for WSN-Assisted IoT. HDM-LEACH is mainly based on a heterogeneous network system model, multi-hop communication, and a hierarchical clustering routing mechanism. Our heterogeneous network system model is composed of two energy-level nodes: normal nodes and advanced nodes. The proposed hierarchical clustering mechanism calculates the CH selection probability in an efficient and dynamic way. According to the simulation results, HDM-LEACH shows performance supremacy compared to existing algorithms in terms of stable period, energy conservation, and network lifetime.
A smart, real-time, secure strategy for allocating and scheduling resources based on fog computing and the multi-objective crow search algorithm
Authors: Kumar Dharmendra 
Published: March 2023

Abstract

Fog computing is a new way of using computers that builds on standard cloud technology by taking advantage of the resources at the user's location to improve services. Because of its advantages, which include cheaper operational costs, better security, and lower network latency, it is the most often used option for many real-time applications. However, since each fog device is different, it is hard to figure out how to divide up and schedule resources. This paper proposes a novel approach for resource allocation and scheduling in a fog computing environment using a crow search mechanism and a multi-objective population-based evolutionary mechanism. The proposed work considers two goals: the security hit rate and the success rate. These two aims must be met to the greatest extent possible. A local search method improves how well the crow search algorithm (CSA) works. The suggested work uses the evolutionary method to figure out how to schedule and divide resources in a fog computing environment. We have contrasted the effectiveness of our suggested hybrid CSA with two other approaches, the original CSA and the Genetic Algorithm (GA), based on two metrics: success rate and security hit ratio. We have used seven different scenarios with different values for the parameters. We found that our proposed hybrid CSA outperformed other currently employed methods. The study's outcome also shows how well the suggested algorithm accomplishes its objectives.
Poverty line income and fisheries subsidies in developing country fishing communities
Authors: Teh Louise Siok Ling , Teh Lydia Chi Ling , Sumaila Ussif Rashid , Nava Alfredo Giron 
Published: March 2023

Abstract
Eradicating poverty and harmful fisheries subsidies are two pressing challenges frequently addressed in international agendas for sustainable development. Here we investigate a potential solution for addressing both challenges simultaneously by asking the hypothetical question: to what extent can harmful fisheries subsidies provided by a country finance the cost of lifting fishers out of poverty? Focusing on 30 coastal least developed countries, we find that fishers in 87% of these countries do not earn sufficient income to satisfy the extreme poverty line income of USD 1.90/person/day, and that it costs an estimated USD 2.2 to 2.6 billion to lift these fishers to different levels of poverty line incomes. Our analysis further suggests that at the country level, redirected harmful fisheries subsidies can cover the entire cost of covering the poverty income gap for between 37 to 43% of assessed countries. Our results provide quantitative evidence that can be used to support simultaneous progress towards achieving several Sustainable Development Goals, including those dealing with poverty reduction, food insecurity, and ocean sustainability.
GLONASS Signals Characteristics Analysis and Navigation Performance for Geostationary Satellites
Authors: Wang Meng , Shen Qiang , Tian Xiaobin , Xue Zhiqin 
Published: March 2023

Abstract

The utilization of Global Navigation Satellite System (GNSS) is becoming an attractive approach for autonomous navigation of the geostationary orbit (GEO) satellites. As one of the global navigation systems, the feasibility of using GLONASS in high orbit spacecraft has attracted attention. A receiver compatible with GLONASS has been mounted in the GEO satellites of TJS-2 and TJS-5 to demonstrate the ability of tracking signals and real-time orbit determination. In accordance with flight data, the GLONASS signal characteristics are analyzed, including the observations availability and distribution. When the side lobe signals are considered, the mean number of GLONASS satellites tracked increases from 1.8 to 5.8. The transmit power of each GLONASS satellite was estimated by using the C/N0 measurements. Based on the influence analysis results, we found that the side lobe signals transmit power plays an important role in increasing the number of observations. In particular, we investigate the characteristics, such as quantity, C/N0 and Doppler, of the GLONASS antipodal satellites signals tracked simultaneously in the GEO scenario. We give the navigation performance assessment based on GLONASS-only flight data through comparisons with the precision reference orbits. For single-epoch least square solutions, the root mean squares (RMS) of position differences in radial, along-track, and cross-track is 157.0, 29.5, and 21.5 m, respectively. The navigation accuracy is significantly improved when using the real-time orbit determination method and the RMS of position differences in radial, along-track, and cross-track is 5.19, 8.98, and 3.15 m, respectively.
Comparison of changes in health-related quality of life between elderly and non-elderly patients undergoing elective surgery for colorectal cancer
Authors: Watanabe Toshifumi , Ohno Ryo , Kajitani Ryuji , Sahara Kurumi , Munechika Taro , Matsumoto Yoshiko , Aisu Naoya , Kojima Daibo , Yoshimatsu Gumpei , Hasegawa Suguru 
Published: March 2023

Abstract
Purpose Elderly people are thought to be more likely than their non-elderly counterparts to experience a decline in activities of daily living (ADL) and quality of life (QOL) due to the onset and treatment of disease. In this study, we investigated whether there was an age-related difference in changes in health-related QOL indices after surgical resection of colorectal cancer.
Methods Patients who underwent elective surgery for primary colorectal cancer at our hospital between September 2017 and November 2021 were enrolled. Changes in QOL after surgery were evaluated after dividing the study population into a non-elderly (NE) group (younger than 75 years) and an elderly (E) group. A self-administered Short-Form 36-Item Health Survey was used as an index of QOL. The subscale and component summary scores before and 6 months after surgery were compared.
Results There was no significant difference in clinical or demographic characteristics between the NE group (n=166) and the E group (n=47). There was also no significant difference in worsening of indices of physical function after surgery in either group. In the NE group, there were significant decreases in role physical and role component summary scores and significant increases in general health, mental health, and mental component summary scores. In the E group, there were no significant changes in the subscale or component summary scores after surgery.
Conclusion There was no significant difference in QOL after surgery for colorectal cancer between elderly patients and non-elderly patients. Surgical resection for colorectal cancer should be considered even for elderly patients, while considering possible risk factors for worsening ADL and QOL.
The Cost of Addressing Food Insecurity: An Economic Analysis of the Implementation of a Hospital-Based Medical Food Pantry
Authors: Jacobs Molly , Haldeman Lauren , Sastre Lauren R 
Published: March 2023

Abstract
Background: This study compares the cost of implementing a Medical Food Pantry (MFP) serving food insecure (FIS) patients to the predicted hospital utilization costs incurred in the absence of a MFP by FIS patients.
Methods: This case-control study utilized propensity score matching was usedto match patients identified as FIS who received a voucher to a MFP to individuals in the Medical Expenditure Panel Survey (MEPS) to estimate healthcare utilization and costs. Participants were patients identified as food insecure during an in-patient stay who received a voucher for an emergency tailored food bag: carb controlled, sodium controlled, general healthful between June 2018-July 2019. Patients were grouped based on redemption status (redeemed a voucher (RV) =206, did not redeem (NRV) =336).
Results: FIS patients who did not redeem a voucher had higher average cost per inpatient visit compared to those who redeemed their voucher (RV: $13,464.87 vs. NRV: $15,238.63). They also had higher aggregate annual expenditures (RV: $46,112.52 vs. NRV: $50,071.59). The total cost of the MFP was estimated to be $300 per patient voucher redeemed resulting in estimated savings cost saving of $1773.76 per inpatient visit or $3,959.07 per year in healthcare cost.
Conclusions: While our previous work showed that a hospital-based MFP was associated with lower hospital readmissions, this research suggests that the cost of addressing nutritional risks through a hospital-based MFP is feasible and cost-effective.
Amplicon sequencing allows differential quantification of closely related parasite species: an example from rodent coccidia (Eimeria)
Authors: Ferreira Susana Carolina Martins , Jarquín-Díaz Víctor Hugo , Heitlinger Emanuel 
Published: March 2023

Abstract
Background: Quantifying infection intensity is a common goal in parasitological studies. We have previously shown that the amount of parasite DNA in faecal samples can be a biologically meaningful measure of infection intensity, even if it does not agree well with complementary counts of transmission stages (oocysts in case of Coccidia). Parasite DNA can be quantified at relatively high throughput using quantitative polymerase chain reaction (qPCR), but amplification needs a high specificity and does not distinguish between parasite species. Counting of amplified sequence variants (ASVs) from high-throughput marker gene sequencing using a relatively universal primer pair has the potential to distinguish between closely related co-infecting taxa and to uncover the community diversity, thus being both more specific and more open-ended.
Methods: We here compare qPCR to the sequencing based amplification using standard PCR and a microfluidics PCR to quantify the unicellular parasite Eimeriain experimentally infected mice. We use multiple amplicons to differentially quantify Eimeria spp. in a natural house mice population.
Results: We show that sequencing based quantification has high accuracy. Using a combination of phylogenetic analysis and the co-occurrence network, we distinguish three Eimeria species in naturally infected mice based on multiple marker regions and genes. We investigate geographical and host related effects on Eimeria spp. community composition and find, as expected, prevalences to be largely explained by sampling locality (farm). Controlling for this effect, the novel approach allowed us to find body condition of mice to be negatively associated with Eimeria spp. abundance.
Conclusions: We conclude that amplicon sequencing provides underused potential for species distinction and simultaneous quantification of parasites in faecal material. The method allowed to detect a negative effect of Eimeriainfection on body condition of mice in the natural environment.
Examining the Nonlinear Effects of Neighborhood Housing +Transportation Affordability on Shared Dockless E-Scooter Trips Using Machine Learning Approach
Authors: YANG WOOKJAE , Ewing Reid 
Published: March 2023

Abstract
Despite the growing popularity and benefits of shared dockless e-scooter, there is controversy over whether this mode is an affordable travel mode for everyone. This paper explores the nonlinear relationship between shared dockless e-scooters and the location affordability of neighborhoods. By analyzing shared dockless e-scooter trip data collected between April 2019 and March 2020 from 1,886 census block groups in Los Angeles, we used a random forest method to investigate this nonlinear relationship. The variable importance plot revealed that economic variables (cost versus income) have greater explanatory power than others. In the partial dependency plots, neighborhoods spending more than 35% of their income on housing costs were more inclined to use e-scooters. On the other hand, when transportation represents more than 9% of household income, the e-scooter trip density decreases.
The results of this study highlight the importance of location-specific planning in promoting the effective use of shared dockless e-scooters as a sustainable and active transportation mode beyond simply focusing on costs and incentive programs.
Geriatric Nutritional Risk Index after Neoadjuvant Chemoradiotherapy and Survival in Older Patients with Advanced Rectal Cancer
Authors: Amano Takahiro , Akiyoshi Takashi , Furuta Momoko , Saino Yoko , Mukai Toshiki , Hiyoshi Yukiharu , Nagasaki Toshiya , Yamaguchi Tomohiro , Kawachi Hiroshi , Fukunaga Yosuke 
Published: March 2023

Abstract
PurposeTo investigate the clinical impact of malnutrition on survival in older patients with advanced rectal cancer undergoing neoadjuvant chemoradiotherapy.
Methods We investigated the clinical significance of the geriatric nutrition risk index (GNRI) in 237 patients older than 60 with clinical stage II/III rectal adenocarcinoma treated with neoadjuvant long-course chemoradiotherapy or total neoadjuvant therapy followed by radical resection from 2004 to 2017. Pre-treatment and post-treatment GNRI were evaluated, and patients were divided into low (<98) and high (≥98) GNRI groups. The prognostic impact of pre-treatment and post-treatment GNRI levels on overall survival and disease-free survival were evaluated using univariate and multivariate analyses.
Results Fifty-seven patients (24.1%) before neoadjuvant treatment and 94 patients (39.7%) after neoadjuvant treatment were categorized as low GNRI. Pre-treatment GNRI levels were not associated with overall survival (p = 0.80) or disease-free survival (p = 0.77). Patients in the post-treatment low GNRI group had significantly poorer overall survival than those in the post-treatment high GNRI group (p = 0.0005). The multivariate analysis showed that post-treatment low GNRI levels were independently associated with poorer overall survival (hazard ratio, 3.25; 95% confidence interval, 1.26-8.36; p = 0.02). Although post-treatment GNRI levels were not associated with disease-free survival (p= 0.24), among the 50 patients with recurrence, post-treatment low GNRI levels were associated with poorer post-recurrence survival (p = 0.006).
Conclusion Post-treatment GNRI is a promising nutritional score associated with overall survival and post-recurrence survival in older patients with advanced rectal cancer treated with neoadjuvant chemoradiotherapy.