bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrodynamics and climate: reformulation
Authors: Giraud Gaël , Valcke Paul 
Published: September 2023

Abstract
Designing policy for global warming requires an integrated analysis of the interplay between the economy and the environment. The consensus is growing that, despite their dominance in the economics literature and their influence in public discussion and policymaking, the methodology employed so far by most Integrated Assessment Models (iams) ‘rests on flawed foundations’ (Stiglitz et al. 2016). This is particularly worrisome in the face of the immense risks and challenges of global warming and the radical changes in our economies that an effective response requires. This paper introduces an alternative paradigm, idee (Integrated Dynamic Environment-Economy), based on coupling a medium-size climate model with nonlinear, out-of-equilibrium, stock-flow-consistent macroeconomic dynamics in continuous time. Idee allows for multiple economic steady states, endoRgenous business cycles, endogenous growth, corporate default, and the short- and long-run assessment of various mitigation and adaptation policies. We argue that this approach is suitable for providing insights into managing the transition to net-zero emissions and coping with damages induced by the ecological crisis.
Genetic Mapping, Identification, and Characterization of a Candidate Susceptibility Gene for Powdery Mildew in Cannabis sativa
Authors: Stack George M. , Cala Ali R. , Quade Michael A. , Toth Jacob A. , Monserrate Luis A. , Wilkerson Dustin G. , Carlson Craig H. , Mamerto Allen , Michael Todd P. , Crawford Seth , Smart Christine D. , Smart Lawrence B. 
Published: September 2023

Powdery mildew (PM) in Cannabis sativa is most frequently caused by the biotrophic fungus Golovinomyces ambrosiae. Based on previously characterized variation in susceptibility to PM, biparental populations were developed by crossing the most resistant cultivar evaluated, ‘FL 58’, with a susceptible cultivar, ‘TJ's CBD’. F1 progeny were evaluated and displayed a range of susceptibility, and two were self-pollinated to generate two F2 populations. In 2021, the F2 populations ( n = 706) were inoculated with PM and surveyed for disease severity. In both F2 populations, 25% of the progeny were resistant, while the remaining 75% showed a range of susceptibility. The F2 populations, as well as selected F1 progeny and the parents, were genotyped with a single-nucleotide polymorphism array, and a consensus genetic map was produced. A major effect quantitative trait locus on C. sativa chromosome 1 (Chr01) and other smaller-effect quantitative trait loci (QTL) on four other chromosomes were identified. The most associated marker on Chr01 was located near CsMLO1, a candidate susceptibility gene. Genomic DNA and cDNA sequencing of CsMLO1 revealed a 6.8-kb insertion in FL 58, relative to TJ's CBD, of which 846 bp are typically spliced into the mRNA transcript encoding a premature stop codon. Molecular marker assays were developed using CsMLO1 sequences to distinguish PM-resistant and PM-susceptible genotypes. These data support the hypothesis that a mutated MLO susceptibility gene confers resistance to PM in C. sativa and provides new genetic resources to develop resistant cultivars. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Enhanced Resistance to Viruses in Nicotiana edwardsonii ‘Columbia’ Is Dependent on Salicylic Acid, Correlates with High Glutathione Levels, and Extends to Plant-Pathogenic Bacteria and Abiotic Stress
Authors: Király Lóránt , Zechmann Bernd , Albert Réka , Bacsó Renáta , Schwarczinger Ildikó , Kolozsváriné Nagy Judit , Gullner Gábor , Hafez Yaser Mohamed , Künstler András 
Published: September 2023

Our earlier research showed that an interspecific tobacco hybrid ( Nicotiana edwardsonii ‘Columbia’ [NEC]) displays elevated levels of salicylic acid (SA) and enhanced resistance to localized necrotic symptoms (hypersensitive response [HR]) caused by tobacco mosaic virus (TMV) and tobacco necrosis virus (TNV), as compared with another interspecific hybrid ( Nicotiana edwardsonii [NE]) derived from the same parents. In the present study, we investigated whether symptomatic resistance in NEC is indeed associated with the inhibition of TMV and TNV and whether SA plays a role in this process. We demonstrated that enhanced viral resistance in NEC is manifested as both milder local necrotic (HR) symptoms and reduced levels of TMV and TNV. The presence of an adequate amount of SA contributes to the enhanced defense response of NEC to TMV and TNV, as the absence of SA resulted in seriously impaired viral resistance. Elevated levels of subcellular tripeptide glutathione (GSH) in NEC plants in response to viral infection suggest that in addition to SA, GSH may also contribute to the elevated viral resistance of NEC. Furthermore, we found that NEC displays an enhanced resistance not only to viral pathogens but also to bacterial infections and abiotic oxidative stress induced by paraquat treatments. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Aerial Mapping of the Peruvian Chira Valley Banana Production System to Monitor the Expansion of Fusarium Wilt Caused by Tropical Race 4
Authors: Tagami Giuliana Nakasato , van Westerhoven Anouk C. , Seidl Michael F. , van der Sluis Jaap , Cozzarelli Mario , Balarezo Camminati Diego , Pflücker Rafaël , Márquez Rosillo Claudio , Clercx Luud , Kema Gerrit H. J. 
Published: September 2023

The recent incursion of Fusarium wilt of banana (FWB) caused by TR4 threatens banana production in the Chira Valley of Peru. To develop a management strategy, we mapped the entire production area from the air. During 12 flights at an altitude of 610 m (2,000 ft), we gathered 133,700 images in a timeframe of 2 weeks and constructed an orthomosaic map of 73,000 ha. This unveiled the complex logistic network across the banana-producing region, comprising 150 km of primary roads, as well as numerous secondary and tertiary unpaved paths through and bordering banana plantations. Moreover, the Poechos reservoir—with a total length of 450 km—feeds the entire Chira Valley irrigation system, which could further exacerbate TR4 expansion. Using georeferenced landscape details (digital terrain model), we determined areas prone to flooding, which is also relevant for disseminating TR4. Analyses of the maps resulted in the identification of many suspect areas for direct sampling and subsequent analyses to study the expansion of TR4. At four locations, we confirmed two cases, and by June 8, 2023, a total of 207 cases were reported. We conclude that TR4 is a serious threat to the entire region, which exports approximately 25% of the global organic bananas. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
A Telomere-to-Telomere Genome Assembly Resource of Bipolaris sorokiniana, the Fungal Pathogen Causing Spot Blotch and Common Root Rot Diseases in Barley and Wheat
Authors: Leng Yueqiang , Du Yang , Fiedler Jason , Haridas Sajeet , Grigoriev Igor V. , Zhong Shaobin 
Published: September 2023

Bipolaris sorokiniana ( Cochliobolus sativus) is a fungal pathogen that causes spot blotch, common root rot, and kernel blight in barley and wheat. Four pathotypes (0, 1, 2, and 7) of the fungus were previously identified based on their virulence on three barley differential lines (Bowman, ND 5883, and NDB 112). Although several genome assemblies have been reported for B. sorokiniana, a telomere-to-telomere genome assembly is still lacking for this fungus. In this study, we assembled the genome of a pathotype 0 isolate (ND93-1) of B. sorokiniana using both PacBio HiFi reads and ultralong Oxford Nanopore Technology reads corrected with Illumina paired-end 100-bp short reads. The combined genome assembly of ND93-1 has an estimated size of 35.7 Mb and consists of 16 scaffolds, each having two telomeres. A total of 11,564 protein-coding genes were predicted, including 1,633 genes encoding for secretory proteins and 473 genes for effectors. This telomere-to-telomere genome assembly provides an important resource for comparative genomics and understanding molecular biology of B. sorokiniana and related Bipolaris species. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Public experience with and perspectives on medical care provided by PAs
Authors: Kozikowski Andrzej , Morton-Rias Dawn , Quella Alicia , Puckett Kasey , Jeffery Colette , Mauldin Sheila , Goodman Joshua 
Published: September 2023

ABSTRACT

Objective:
We sought to assess public experiences with and perspectives about physician associates/assistants (PAs), who are taking on increasingly important roles in healthcare.

Methods:
We conducted a survey using a Qualtrics panel assessing whether participants (N = 1,388) received care from PAs, their perceptions of the care received, and their intentions of seeking care from PAs in the future.

Results:
About 67% of participants reported receiving care from PAs; 61.7% believed PAs have more time to communicate with patients. Most respondents were satisfied with the care received, said they were likely to see a PA again, and recommended PAs. Of those not treated by PAs, 30.6% were willing to receive care from PAs, 43.8% were willing to receive care from PAs for minor medical needs, 21.3% were unsure, and 4.3% were unwilling. Older participants and those with more education had consistently more favorable views.

Conclusions:
Public experiences with and perceptions of PAs are positive. Future research should employ longitudinal designs to assess trends as the PA workforce continues to grow.
The effect of psychosocial stress on prenatal care among Hispanic immigrant women
Authors: Ahmed Sarah , Pablo Nicole , Mui Sammie , Verdeyen Elyse , Robinson Terri , Gillette Chris , Hussaini Sobia Shariff 
Published: September 2023

ABSTRACT
This article explores the effect of psychosocial stress on Hispanic immigrant women, including access to and use of prenatal care and birth outcomes. In addition to highlighting the health effects for this growing population, the article outlines strategies for clinicians to improve access to adequate prenatal care and to cultivate a supportive environment to promote use of prenatal services.
Perceptions of Addiction Medications Within Collegiate Recovery Communities
Authors: Tuliao Antover P. , Tuliao Minerva D. , Lewis Lauren E. , Mullet Natira D. , North-Olague Justin , Mills Devin , Kimball Thomas , Shumway Sterling 
Published: September 2023

Objectives
Addiction medications (AM) are effective in improving recovery outcomes, but many barriers still exist that reduce their implementation among young adults. While the perception of AM has been explored within clinicians and counselors in many settings, it has not yet been documented within collegiate recovery communities (CRC). The aim of this brief report is to assess the acceptability and intent to use AM among students in recovery, and to evaluate the effect of attitudes, perceived AM effectiveness, and social norms on these outcomes.

Methods
Using the Theory of Planned Behavior, CRC students (N = 162; 44% female) within the United States completed an online survey.

Results
Results from a hierarchical linear model indicated that the perceived acceptance of AM use by important others was significantly related to the intent to use AM (β = 0.47, P < 0.01) and encourage others to use AM (β = 0.16, P < 0.05). Positive attitudes about AM predicted acceptability of AM use (β = 0.42, P < 0.01) and encouraging other CRC students to use AM (β = 0.38, P < 0.01). Perceived AM effectiveness was positively associated with acceptability (β = 0.36, P < 0.01) and encouragement of others (β = 0.27, P < 0.01).

Conclusions
Results highlight the importance of promoting effectiveness, improving attitudes, and tapping social networks to increase AM use and acceptability among CRC students. Implications for CRC policy and programming are discussed.
Decline in Prenatal Buprenorphine/Naloxone Fills during the COVID-19 Pandemic in the United States
Authors: O’Donoghue Ashley L. , Reichheld Alyse , Anderson Timothy S. , Zera Chloe A. , Dechen Tenzin , Stevens Jennifer P. 
Published: September 2023

Objectives
Pregnancy provides a critical opportunity to engage individuals with opioid use disorder in care. However, before the COVID-19 pandemic, there were multiple barriers to accessing buprenorphine/naloxone during pregnancy. Care disruptions during the pandemic may have further exacerbated these existing barriers. To quantify these changes, we examined trends in the number of individuals filling buprenorphine/naloxone prescriptions during the COVID-19 pandemic.

Methods
We estimated an interrupted time series model using linked national pharmacy claims and medical claims data from prepandemic (May 2019 to February 2020) to the pandemic period (April 2020 to December 2020). We estimated changes in the growth rate in the monthly number of individuals filling buprenorphine/naloxone prescriptions in the 6 months preceding a delivery claim, per 100,000 pregnancies, during the COVID-19 pandemic.

Results
We identified 2947 pregnant individuals filling buprenorphine/naloxone prescriptions. Before the pandemic, there was positive growth in the monthly number of individuals filling buprenorphine/naloxone prescriptions (4.83%; 95% confidence interval [CI], 3.82–5.84%). During the pandemic, this monthly growth rate declined for both individuals on commercial insurance and individuals on Medicaid (all payers: −5.53% [95% CI, −6.65% to −4.41%]; Medicaid: −7.66% [95% CI, −10.14% to −5.18%]; Commercial: −3.59% [95% CI, −5.32% to −1.87%]).

Conclusion
The number of pregnant individuals filling buprenorphine/naloxone prescriptions was increasing, but this growth has been lost during the pandemic.
Effect of COVID-19 on the Long-term Cardiovascular Outcomes among Patients with Alcohol Use Disorder: A Retrospective Cohort Study Including 45,842 Patients
Authors: Liu Ting-Hui , Wu Jheng-Yan , Huang Po-Yu , Tsai Ya-Wen , Lai Chih-Cheng 
Published: September 2023

Objectives
This study was conducted to determine the risk of major acute cardiovascular events (MACEs) following COVID-19 among patients with alcohol use disorder (AUD).

Methods
This is a 1-year follow-up retrospective cohort study that used data from TriNetX, a multi-institutional research network platform. We compared the risks of incident MACEs in patients with AUD who had a positive diagnosis for COVID-19 and patients who had not had COVID-19 during the follow-up year.

Results
We enrolled 45,842 patients with AUD with and without COVID-19 history who had similar baseline characteristics from matching. During the follow-up period, the patients with AUD with COVID-19 history had a higher risk of overall MACEs than that of those without COVID-19 history (hazard ratio [HR], 2.013; 95% confidence interval [CI], 1.810–2.240). In addition, the patients with AUD with COVID-19 history had a higher risk of myocardial infarction (HR, 3.778; 95% CI, 2.873–4.969), stroke (HR, 2.411; 95% CI, 2.016–2.883), heart failure (HR, 2.206; 95% CI, 1.866–2.607), arrhythmia (HR, 2.359; 95% CI, 2.041–2.727), and inflammatory heart disease (HR, 3.042; 95% CI, 1.976–4.682).

Conclusions
Patients with AUD who survived COVID-19 had a significantly higher risk of incident cardiovascular diseases within 12 months than that of the patients with AUD without COVID-19 history.
Impact of risk perception and disease cognition on the willingness to participate in screening for lung cancer in a high-risk population
Authors: Rong Feng , Shi Rui , Hu Lili , Wang Daoyue , Lv Xiazhi , Zhao Yong 
Published: September 2023

Objective
Risk perception and disease cognition may influence the efficiency of lung cancer screening by affecting the participation rate. There is still some uncertainty regarding the association between risk perception and disease cognition and how they affect participation in lung cancer screening. Therefore, we explored the influence of risk perception and disease cognition on the willingness to participate in screening among people at high risk of lung cancer.

Methods
Subjects with high-risk factors for lung cancer were recruited in Lu’an City, Anhui Province, China. Questionnaires were used to determine their demographic characteristics, risk perception, disease cognition, and willingness to engage in screening.

Results
Of the 1955 subjects with high risk factors for lung cancer, 1136 (58.12%) were willing to participate in lung cancer screening. Univariable and multivariable analyses showed that disease cognition (adjOR = 2.012, 95% CI: 1.528–2.649, P = 0.000), cognitive risk (adjOR = 7.661, 95% CI: 6.049–9.704, P = 0.000), and affective risk (adjOR = 5.964, 95% CI: 4.552–7.815, P = 0.000) were significant factors in promoting screening participation. For those with moderate risk perception, improving disease cognition was a key approach to increase screening participation.

Conclusion
This study elucidated the relationship between various factors and lung cancer screening participation and proposed a feasible route for the screening implementation, providing a theoretical basis to further improve the participation rate and efficiency of lung cancer screening.
Redo inferior pubectomy for failed anastomotic urethroplasty in pelvic fracture urethral injury
Authors: Wang Lin , Song Wenxiong , Peng Xufeng , Lyu Rong , Wang Jijian , Jin Chongrui , Feng Chao , Lyu Xiangguo , Sa Yinglong , Liu Yidong 
Published: September 2023

Abstract

Objectives
To assess the effect of redo inferior pubectomy on the management of complicated pelvic fracture urethral injury (PFUI) in patients with a history of failed anastomotic urethroplasty.

Materials and methods
We retrospectively reviewed all patients receiving redo anastomotic urethroplasty with redo inferior pubectomy for failed PFUI between January 2010 and December 2021. Patients with incomplete data and those who were lost to follow-up were excluded. Successful urethroplasty was defined as the restoration of a uniform urethral caliber without stenosis or leakage and further intervention. Functional results, including erectile function and urinary continence, were evaluated. Descriptive statistical analyses were then performed.

Results
Thirty-one patients were included in this study. Among them, concomitant urethrorectal fistula occurred in 2 patients, and concomitant enlarged bladder neck occurred in 1. The stenosis site was the bulbomembranous urethra in 2 patients and the prostatomembranous urethra in 29. The mean length of urethral stenosis in all patients was 3.1 cm (range, 2.0–5.0 cm). After a mean follow-up of 34.6 months, the final success rate was 96.8%. The incidence of erectile dysfunction reached 77.4% (24/31). Normal continence was achieved in 27 (87.1%) patients. One patient developed urinary incontinence of grade II requiring urinary pads because of an enlarged bladder neck. According to the Clavien-Dindo classification, postoperative complications of grade I occurred in 7 patients and grade II in 4.

Conclusions
Repeat anastomotic urethroplasty with repeat inferior pubectomy provides reliable success rates for failed PFUI. In complicated cases, it should be known and mastered.
Receipt of Behavioral Therapy in Preschool-Age Children with ADHD and Coexisting Conditions: A DBPNet Study
Authors: Mittal Shruti , Bax Ami , Blum Nathan J. , Shults Justine , Barbaresi William , Cacia Jaclyn , Deavenport-Saman Alexis , Friedman Sandra , LaRosa Angela , Loe Irene M. , Tulio Shelby , Vanderbilt Douglas , Harstad Elizabeth 
Published: September 2023

ABSTRACT:

Objective:
Practice guidelines from the American Academy of Pediatrics and Society for Developmental and Behavioral Pediatrics recommend evidence-based behavioral therapy (BT) as first-line treatment for preschool-age children with ADHD, prior to medication initiation. Thus, this study's objective is to present the frequency of physician-documented receipt of BT in preschool-age children with ADHD prior to medication initiation and to determine factors associated with receipt BT receipt.

Methods:
This retrospective medical record review was conducted across 7 Developmental Behavioral Pediatrics Research Network (DBPNet) sites. Data were abstracted for children <72 months old seen by a DBP clinician and initiated on ADHD medication between 1/1/2013-7/1/2017. From narrative text of the medical records, BT receipt was coded as: parent training in behavior management (PTBM), Applied Behavior Analysis (ABA), other, or did not receive.

Results:
Of the 497 children in this study; 225 children (45%) had reported receipt of any BT prior to ADHD medication initiation, with 15.9% (n = 79) receiving PTBM. Children with co-existing diagnoses of ASD or disruptive behavior disorder were more likely to receive BT than children without co-existing conditions (59.3% vs 69.0% vs 30.6%). There was significant site variability in reported receipt of BT, ranging from 22.4% to 74.1%, and sex and insurance were not associated with BT rates.

Conclusion:
The percentage of children with documented receipt of any BT, and particularly PTBM, was low across all sites and co-existing conditions. These findings highlight the universal need to increase receipt of evidence-based BT for all young children with ADHD.
Clinical Course, Therapeutic Management and Outcome of Coronavirus Disease in Patients With Inborn Errors of Immunity: A Retrospective Multicenter Experience From Iran
Authors: Karimi Abdollah , Jamee Mahnaz , Shokri Youssef , Heidari Atefeh , Nazarpack Fatemeh , Fallahi Mazdak , Shiari Reza , Li Philip H. , Sharifinejad Niusha , Sharafian Samin , Mahdaviani Seyed Alireza , Mansouri Davood , Zeinali Amirreza , Alyasin Soheila , Chavoshzadeh Zahra ,   on behalf of the Study Group
Published: September 2023

Background:
Inborn errors of immunity (IEIs) are characterized by defects in the structure and function of the immune system. This study was designed to assess the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on this potentially particularly susceptible group of patients.

Methods:
This retrospective cross-sectional study analyzed patients from 3 referral immunodeficiency centers in Iran. The demographic, clinical, laboratory and therapeutical data of confirmed IEI patients with SARS-CoV-2 infection were collected and analyzed.

Results:
A total of 19 IEI patients, 52.6% male and 47.4% female, with coronavirus disease 2019 (COVID-19) were enrolled. The most common diagnosed IEIs were (severe) combined immunodeficiency ((S)CID) (9, 47.4%) and predominantly antibody deficiencies (7, 36.8%). The main presenting symptoms included fever (16, 84.2%), cough (12, 63.2%), dyspnea (9, 47.4%) and myalgia (8, 42.1%). Among additional preexisting comorbidities, atopy (P = 0.087) and renal disorders (P = 0.087) were more strongly associated with the development of respiratory failure, although not statistically significant. SARS-CoV-2 infection was determined by polymerase chain reaction (n = 19, 100%) within a median (interquartile range) of 1 (0–6) days following admission. Among all laboratory indices, thrombocytopenia (P = 0.009) was associated with a need for intensive care unit admission. The overall mortality rate was 36.9% and highest among (S)CID patients (4, 44.4%).

Conclusions:
Severe COVID-19 most frequently affected (S)CID and predominantly antibody deficiencies patients among this multicenter Iranian cohort. Further studies are required to evaluate the impact of additional preexisting comorbidities and the development of thrombocytopenia on the severity and prognosis of COVID-19 in IEIs.