bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTATION OF INFRASTRUCTURE PROJECTS FOR THE DEVELOPMENT OF RAILWAY TRANSPORT HUBS: EMPIRICAL ANALYSIS
Authors: Kuzmin P. S. 
Published: February 2023

The key tool for economic growth and overcoming restrictions is the implementation of major infrastructure projects in the field of railway transport. Infrastructure projects aimed at organising passenger and freight rail traffic form a wide range of social effects, such as saving travel time, improving transportation safety, reducing emissions of harmful substances and noise levels, increasing physical activity, improving social integration and organising a barrier-free environment, agglomeration effects and an increase in subjective well-being.At the same time, such projects are very capital-intensive and often cannot be implemented in full due to limited funding. Especially this factor plays a significant role in the current conditions of sanctions pressure. The combination of these factors leads to the need for comprehensive risk management when deciding on the implementation of an infrastructure project for the development of railway junctions.Thus, the purpose of this study is to identify risks in the implementation of infrastructure projects, assess the identified risks and formulate recommendations for their reduction.
El Instituto Nacional del Cooperativismo (INACOOP) y las políticas públicas de promoción del cooperativismo
Authors: Gutiérrez Fiori Danilo 
Published: February 2023

En este artículo se realiza un recorrido breve por la historia de la política pública y la institucionalidad previa a la aparición de INACOOP con el fin de ubicar al Instituto en el escenario nacional y poder apreciar la dimensión de los cambios operados. Luego se analizan las condiciones internas que favorecieron su creación y las ideas inspiradoras que dan sustento a la nueva institucionalidad. Se analiza su figura jurídica y su sistema de gobernanza con énfasis en la cocreación de política pública y el papel articulador que la institución tiene con los entes estatales y el movimiento cooperativista y la economía social. Se repasan las políticas desarrolladas en permanente conexión con otros actores. Se relata la evolución legislativa por la que se le atribuyeron nuevas herramientas y la extensión a un universo más amplio de destinatarios. Finalmente, se resalta la continuidad de las grandes políticas públicas, que trascienden el lapso de cada período de gestión.
Recibido: 03 noviembre 2022Aceptado: 12 enero 2023
Anemia in children and adolescents with inflammatory bowel disease at the time of diagnosis and after 1 year of treatment
Authors: Ferant Žan , Pogačar Maja , Dolinšek Jernej , Mičetić-Turk Dušanka 
Published: February 2023

Purpose: Purpose: Anemia is the most common systemic complication of inflammatory bowel disease (IBD). Depending on the diagnostic criteria and patient sub-population, the prevalence of anemia can be as high as 73.7%. Data suggest that the prevalence of anemia is often higher in the pediatric population than adults. The presence of anemia can have a significant impact on the quality of life (QOL) in patients with IBD, which can be as poor as exists in patients with advanced cancer; however, the QOL improves with restoration of the hemoglobin concentration. Because the anemia in patients with IBD is often unrecognized and/or undertreated, this potentially reversible condition is an area of great concern.
Methods: We retrospectively collected data for 44 pediatric patients (age range, 10–18 years; mean age, 14.3 years; 25 boys and 19 girls) at the time of diagnosis and after 1 year of IBD treatment and compared the IBD patients to 36 healthy children and adolescents (age range, 10–18 years; mean age, 13.7 years; 17 boys and 19 girls). We recorded the prevalence of anemia based on the World Health Organization criteria, the hemoglobin concentration, mean corpuscular volume, and iron and ferritin levels. We also compared IBD patients who were treated for anemia to untreated IBD patients.
Results: Anemia existed in 63% and 18% of IBD patients at the time of diagnosis and 1 year after treatment, respectively, and in 3% of the patients in the control group. Blood parameters in IBD patients improved after 1 year of treatment and approached the values in the control group. Of the IBD patients, 20% were treated for anemia. No statistical significance existed between IBD patients who were and were not treated for anemia.
Conclusion: Our findings suggest that anemia may improve in patients with IBD by treating the underlyingdisease; however, we also found a small percentage of patients who were treated for anemia, which is an issue that must be kept in mind.
The incidence of early postoperative complications after spinal anaesthesia
Authors: Kamenik Mirt , Horvat Smiljana 
Published: February 2023

Purpose: The purpose of our study was to gather data about the incidence of early post-operative complications after spinal anaesthesia at the University Medical Centre Maribor. We were interested in the impact of gender, age, and a number of attempts to insert the spinal needle on the incidence of these complications.
Methods. We studied 90 patients who underwent a surgical procedure involving the lower extremities under spinal anaesthesia. Twenty-four to 72 hours after spinal anaesthesia, we collected data about early complications from a questionnaire and data about technical difficulties associated with the spinal puncture.
Results. Among 90 patients, 23 (25.5 %) reported no complications. The most common complication was tingling in the lower extremities (43 %) and nausea (31 %). Back pain was present in 21 % of patients, 18 % had headaches, 19 % had vertigo, and 13 % had double vision. Headache, diplopia, and dizziness were more common in women, while backache was more common in men. There was a tendency towards an increase in the incidence of complications with age, especially diplopia, vomiting, and dizziness. The incidence of complications was also higher in patients requiring > 3 attempts for effective spinal puncture
Conclusion. Our study showed that complications after spinal anaesthesia occur more often in female patients and in patients > 55 years of age. The most common complications were tingling in the lower extremities, dizziness, and nausea. The incidence of complications was higher in patients requiring > 3 attempts for effective spinal puncture.
Overcoming cultural cleavages: results from a health promotion intervention among Roma
Authors: Zelko Erika , Švab Igor 
Published: February 2023

Purpose: The “SASTIPE” (health in Romani language) pilot project grew from the increasing awareness that the Roma generally have not participated in community-based healthy lifestyle promotion programs. The increasing burden of chronic disease and awareness of the need for a healthier lifestyle amongst the Roma have contributed to the development of an intervention program that was implemented in Roma settlements.
Method: The program took place in nine Roma settlements from December 2012 to March 2013. We provided workshops focused on diabetes, chronically pulmonary diseases (COPD), healthy foods and blood pressure, and emergency preparedness and used specific materials that were developed together with the Roma. Quantitative data was collected using the adapted and validated versions of the EUROPREV and EuroQol questionnaires before and after the intervention. The assessment of the pilot project was made with data from the responders in the intervention group and the control group (response rates 53% and 74%, respectively), where the control group were populations that did not preform any other activities.
Results: The program increased knowledge about some observed medical parameters in the intervention group (p<0.001), and we observed changes in the awareness of healthy lifestyles, especially smoking habits, which we noticed a significant difference between the control and intervention group in the pilot project (p<0.001).
Conclusion: We demonstrated that together with the target group it is possible to develop a successful intervention project. We achieved changes in medical knowledge and increased awareness of the need to change smoking habits and lifestyle within the intervention group. However, further research and longer observation times are needed to achieve a long-term change in lifestyle.
Biocompatibility of supercritical carbon dioxide processed poly(lactide-co-glycolide) and poly(ε-caprolactone) assessed with primary human osteoblasts
Authors: Dariš Barbara , Ferk Polonca , Markočič Elena , Knez Željko 
Published: February 2023

Purpose: In the present study, poly (lactide-co-glycolide) (PLGA) and poly (ε-caprolactone) (PCL) combined with hydroxyapatite (HA) were processed with supercritical CO2 (scCO2) to obtain macroporous foams.
Methods: The in vitro biocompatibility and mineralization of the foams was assessed with primary human osteoblasts (HOB).
Results: The WST-8 (Water-soluble Tetrazolium salts) test for cell proliferation activity and alkaline phosphatase (ALP) activity assay were used to estimate HOB proliferation and differentiation respectively. The proliferation activity of HOB on foamed PLGA and PCL decreased compared to non-foamed polymer, while on PLGA and PCL foamed constructs with hydroxyapatite (HA), the proliferation activity increased compared to the foamed PLGA and PCL.
Conclusions: The ALP activity on PLGA, PCL and foamed PCL was similar to the control, being less intense on PCL foamed constructs with HA, while foamed PLGA and PLGA foamed constructs with HA showed no evidence of ALP activity.
Myocardial revascularization using the posterior intercostal arteries as grafts: anatomical variation aspect
Authors: Kocbek Lidija , Anderhuber Friedrich 
Published: February 2023

Purpose: The posterior intercostal arteries (PIAs) present potential alternative graft sites because of their histological, morphological, and anatomical features. We investigated the anatomical variations of the origin and course of the left fifth and right seventh PIAs, since these arteries have been demonstrated as the most suitable for in situ grafting of the coronary arteries. The aim of this study was to determine whether variations of the PIAs as grafts could influence or limit myocardial revascularization.
Methods: PIAs from the origin to the mid–axillary line were dissected from 44 cadavers embalmed via Thiel's method. The origin and course of the arteries was documented. The lengths of the common trunks, the distances to the costal angle levels, and the diameters of the arteries at the origin, at the point of division from the common trunk, and at the costal angle level were measured to calculate the diameter reduction rate.
Results: Anatomical variations of the left fifth PIA were found in 25% of the cadavers. No variations were found in the right seventh PIAs. The length of the common trunk influences the length of the obtained pedicle. The PIA diameter is dependent on the origin from the aorta. The target PIA should be harvested before the costal angle level to assure a proper diameter of the conduit.
Conclusion: Potential anatomical variations of the PIA must be considered when harvesting a vessel for CABG to avoid technical problems in PIA harvesting and hemodynamic changes.
Large retroperitoneal mass in a 56-year old female
Authors: Arslani Nuhi 
Published: February 2023

Purpose: Müllerian ductal cysts are rare congenital abnormalities of Müllerian system regression, typically located in the pelvis . Their presence in retroperitoneum is extremely rare, as the incidence of retroperitoneal cysts, even of diverse morphology and etiology, is approximately 1 in 100,000 adult admissions. Moreover, they can be classified into lymphatic, mesothelial, enteric, and urogenital cysts. Urogenital cysts are further categorized into pronephric, mesonephric, metanephric, and Müllerian types. However, in both sexes the most common location of the Müllerian cyst is in the pelvis; in men they reside mostly near the prostatic utricle and the appendix of the testis. In women, they may be often confused with primary ovarian or tubal cysts.
Case Report: In this case report, we present a case of a benign retroperitoneal cyst of the Müllerian type in a 56- year old female.
Higher live birth and lower pregnancy loss rates in natural compared with artificial cycle protocols for endometrial preparation of frozen blastocyst transfer
Authors: Reljič Milan , Mlakar Lea , Hadžimehmedović Azra , Kovač Vilma 
Published: February 2023

Purpose: The aim of this study was to compare the reproductive outcomes and live birth rates of natural cycle (NC) and artificial cycle (AC) protocols for endometrial preparation of frozen– thawed embryo transfer (FET).
Methods: A total of 1317 NC and 528 AC protocols for endometrial preparation of FET performed during a 3-year period at a tertiary in vitro fertilisation (IVF) clinic were analysed. The clinical spontaneous abortion, pregnancy, and live birth rates were compared. Logistic regression models were constructed to identify the factors that are significantly associated with the live birth and clinical spontaneous abortion rates.
Results: A significantly lower clinical spontaneous abortion rate (13.68 % vs. 27.32 %; p < 0.001) and a comparable pregnancy and a significantly higher live birth rate (32.82 % vs. 26.70 %; p < 0.01) were associated with the NC compared to the AC protocol. Independent predictors for live birth were maternal age (odds ratio (OR), 0.94; 95% confidence interval (CI), 0.91–0.98), transfer of morphologically- optimal blastocysts (OR, 1.72; 95% CI, 1.28–2.31), and the method used to prepare the endometrium (OR, 0.63; 95% CI, 0.45–0.88). Independent predictors of clinical spontaneous abortion were the method used to prepare the endometrium (OR, 2.26; 95% CI, 1.39–3.68) and maternal age at the time of FET (OR, 1.07; 95% CI, 1.02–1.13).
Conclusions: A better reproductive outcome was observed with the NC protocol; specifically, the clinical spontaneous abortion rate was significantly lower and the live birth rate was significantly higher compared with the AC protocol. Based on better cycle outcomes, patient convenience, and low cost, we suggest using the NC protocol as the first option for FET in patients with regular menses.
Comparison of sensitivity of lung ultrasound and chest x-ray imaging for the diagnosis of community-acquired pneumonia in children
Authors: Berce Vojko 
Published: February 2023

Purpose: Lung ultrasound (LUS) has only recently been considered to be a suitable tool for diagnosing community acquired pneumonia (CAP) in children. Little is known about the usefulness of LUS in different types of pneumonia. Therefore, we analyzed and compared the sensitivity of chest X-ray (CXR) and LUS in different etiological types of CAP in children.
Methods: We performed a prospective study in 166 children with CAP, who were admitted to the hospital. The participants were stratified into bacterial (n=80), atypical bacterial (n=32) and viral (n=54) pneumonia subgroups, according to the laboratory and microbiological results. LUS and CXR were performed on all patients at admission.
Results: Pneumonia was detected with LUS in 161 (97.0%) participants and with CXR in 137 (82.5%) participants (p<0.01). The sensitivity of LUS was calculated as 97.0% (95% CI, 93.1%–99.0%), and the sensitivity of CXR as 82.5% (95% CI, 75.9%– 88.0%), p<0.01. In patients with bacterial CAP, infiltrates were detected with LUS in 79 (98.7%) and with CXR in 67 (83.8%) of cases (p<0.01); in atypical bacterial CAP, with LUS in 30 (93.8%) and with CXR in 28 (87.5%) (p=0.69); and in patients with viral CAP with LUS in 52 (96.3%) and with CXR in 42 (77.8%) (p<0.01).
Conclusion: We have determined that LUS is an excellent tool for diagnosing CAP in children. LUS is at least as sensitive as CXR in all types of CAP in children and will probably replace it as the investigation of choice in CAP.
Polyarteritis nodosa in a 6-year-old girl – a case report and overview of current management techniques of the disease in paediatric patients
Authors: Marčun Varda Nataša , Močnik Mirjam 
Published: February 2023

Purpose: In this article a rare case report of a 6-year-old girl with polyarteritis nodosa (PAN) is presented and current clinical and treatment recommendations and new research data are reviewed. The latter is needed to clearly describe disease presentation, treatment responses, and prognosis in children. PAN is a rare form of vasculitis in children, affecting medium- and smallsized arteries. Its clinical presentation can be quite unspecific and insidious at the beginning, presenting a diagnostic problem.
Methods: Presentation of the patient clinical characteristics, results of the investigation and treatment carried out, as well as the approach to management, treatment, and monitoring of patients with the same condition.
Results: Patient diagnosis was confirmed by laboratory and morphological diagnostics. Treatment with corticosteroids and mycophenolate mofetil was introduced, which led to clinical improvement. The patient requires further lifelong follow-up. Conclusions: Early diagnosis and timely initiation of treatment are of the utmost importance for good prognosis and prevention of devastating irreversible impairment caused byPAN. New multicentre research is needed to improve the treatment of rare paediatric patients with this condition.
Impact of Combined Continuous Treatment on the Symptoms and Quality of Life of Children with Attention Deficit Hyperactivity Disorder: A Prospective Observational Study
Authors: Venek Saška , Gregorič Kumperščak Hojka 
Published: February 2023

Purpose: Although attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, studies involving the long-term treatment effects on symptoms and quality of life (QOL) are few in number and the results are conflicting. The purpose of the current study was todetermine the effect of combined (pharmacologic and non-pharmacologic) continuous treatment on the symptoms and QOL in children with ADHD after initial stabilization of symptoms.
Methods: Seventeen children with ADHD (mean age = 8.5 years; 15 boys and two girls) were included in this prospective observational study. The children were assesed at baseline and 9 months later based on the ADHD Rating Scale (RS), Clinical Global Impression-Severity (CGI-S), and Child Health and Illness Profile/Parent Report Form-76 (CHIP-CE).
Results: After 9 months of treatment, the ADHD RS showed improvement in symptoms in two items closely related to attention (p <0.05); the global value remained unchanged. Furthermore, the CGI-S showed improvement in the severity of ADHD (p <0.05). CHIP-CE showed stability and > 50% improvement in the QOL among participants in four of five domains with no statistically significant difference.
Conclusion: The results of this study suggested that continued treatment of ADHD was justified after initial stabilization of symptoms and further improvement in symptoms and QOL can be expected.
Surgical treatment in severely immunocompromised patient with invasive fungal infection
Authors: Skok Kristijan , Vidovič Damjan , Gačevski Goran , Veingerl Bojan , Auda Jure , Crnjac Anton 
Published: February 2023

Purpose: We present a case report of successful surgical treatment of a 58-year- old severely immunocompromised male patient with invasive fungal infection.
Case presentation: A 58-year-old male with a smoking history of 30 years was admitted to hospital because of sudden shortness of breath. Radiographic imaging showed an extensive pneumothorax. The patient had a history of T-cell lymphoma, B-cell MALT lymphoma, and chronic obstructive pulmonary disease. He had also previously undergone chemotherapy. During hospitalization, his health state started to deteriorate. On the basis of imaging and microbiological culture results, he was diagnosed to have a fungal infection with Aspergillus fumigatus. After careful preoperative care, preparations, and several consultations, we performed video-assisted thoracic surgery. Because of poor visibility, inaccessibility, and rupture of an intercostal artery, we performed thoracotomy with excision of the right lung apex. Histopathology and microbiology results confirmed the initial diagnosis. Postoperatively, a 1-year treatment regimen with voriconazole was introduced. The follow-up CT scan showed no signs of fungal infection progression. The patient was given further instructions and discharged from the hospital in a cardiorespiratory compensated state.
Conclusion: Despite poor prognostic factors, the surgical procedure was successful and the patient’s health state considerably improved.
Effects of intravenous and inhalation induction of anesthesia on oxygen delivery in elderly patients undergoing colorectal surgery
Authors: Mekiš Dušan , Sok Vesna 
Published: February 2023

Purpose: The induction of anesthesia with direct laryngoscopy and orotracheal intubation are two interventions, which can influence oxygen delivery. Rapid adjustments of treatment to restore oxygen delivery are crucial to improving the outcomes for patients. The aim of this study was to compare the effects of induction of anesthesia with propofol and sevoflurane on oxygen delivery in elderly patients undergoing colorectal surgery. Methods: We studied forty patients with physical status II or III, according to the American Society of Anesthesiology,who were older than 65 years and undergoing elective surgery for resection of colorectal carcinoma. The patients were randomly divided into the propofol group (P-group) and sevoflurane group (S-group), according to the anesthetic received for the induction of anesthesia. Results: After induction of anesthesia, heart rate, mean arterial pressure, cardiac output and the oxygen delivery index significantly decreased in both groups compared to the baselinevalues. Following induction of anesthesia, the decrease in heart rate was significantly more rapid in the P-group. Immediately after orotracheal intubation, heart rate, mean arterial pressure, cardiac output and the oxygen delivery index significantly increased in the S-group, but one minute later these diferences were not statistically significant. Heart rate, meanarterial pressure, cardiac output and the oxygen delivery index were significantly lower after orotracheal intubation in both groups, compared to baseline.Conclusion: Prpofol and sevoflurane are clinically comparable in the induction of anesthesia in elderly patients according to the effect on oxygen delivery.
Prolonged, recurrent, spontaneous massive gluteal and femoral bleeding in a patient with five metachronous primary malignancies
Authors: Čretnik Andrej , Šumer Pia , Breznik Silva 
Published: February 2023

Purpose: This study aimed to present the case of prolonged, recurrent, spontaneous massive bleeding in a patient with five metachronous primary malignancies.
Case presentation: A 70-year-old male patient presented with massive hematomas in the gluteal and femoral regions and a 6-year history of prostatic, urethral (penile), right colonic, and right pulmonary carcinoma, with a myeloproliferative disease that recently ended with lymphatic leukemia. Fasciotomies with the evacuation of massive hematomas were performed due to the development of compartment syndrome, which were followed by persistent recurrent bleeding. Despite several surgical interventions with packing, local hemostatic agents and sutures, and selective embolization with immediate clinical discontinuation of bleeding, the digital subtraction angiography showed recurrent bleeding from the peripheral branches of the internal iliac and deep femoral arteries always a few days after the procedures. The coagulation and aggregation parameters and bleeding disorders tests were within normal ranges. The histology showed no malignancy in the affected regions, and no relapse was reported in any regions with previously operated malignant diseases on control computed tomography and positron emission tomography scans.
Conclusion: We could stop the bleeding only with more aggressive, nontarget gradual embolization. Subsequently, hemostasis was achieved, with gradual healing of incisions.