bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic immune-inflammation index as a predictor of prognosis after carotid artery stenting compared with C-reactive protein
Authors: Morikawa Shuji , Okumura Kenji , Inoue Naoya , Ogane Takashi , Takayama Yohei , Murohara Toyoaki 
Published: July 2023

BackgroundImmune-inflammatory processes are highly associated with the progression of atherosclerosis. The systemic immune-inflammation index (SII) is a potential predictor for clinical outcomes in patients with stroke and ischemic heart disease. Therefore, this study aimed to investigate whether SII can accurately predict the short- and long-term prognoses in patients who underwent carotid artery stenting (CAS) compared to that with C-reactive protein (CRP).MethodsThis study was a single-center retrospective investigation. Overall, 129 patients who underwent CAS were categorized into tertiles based on their SII levels. We primarily investigated the long-term major adverse cardiac and cerebrovascular events (MACCE) and secondarily the in-hospital and long-term stroke incidence, as well as all-cause death.ResultsThe in-hospital stroke rate tended to increase with a rise in SII (P= 0.13). Over the 5-year follow-up period, the Kaplan–Meier overall incidence of MACCE was 9.3%, 16.3%, and 39.5% in the lowest to highest tertiles, respectively (log-rank trend test,P<0.001). The rates of stroke and MACCE during the long-term follow-up were significantly higher with increasing SII. Cox regression analysis showed that the highest tertile of SII (>647) was a predictor of the incidence of long-term stroke (hazard ratio (HR), 21.3; 95% confidence interval (CI), 2.41–188;P= 0.006) and MACCE (HR, 3.98; 95% CI, 1.80–8.81;P<0.001). However, after adjusting for both SII and CRP, only SII remained a significant independent predictor, whereas CRP became less relevant. The receiver operating characteristic curve analysis of long-term MACCE showed that the area under the curve (AUC) for SII (AUC, 0.72; 95% CI, 0.60–0.84;P<0.001) was greater than that of CRP (AUC, 0.64; 95% CI, 0.51–0.77;P= 0.040).ConclusionSII was shown to be an independent predictor of long-term prognosis in patients who underwent CAS and was suggested to be superior to CRP as an inflammatory prognosis predictor.
Mesenteric panniculitis in rheumatologist practice
Authors: Egorova O. N. , Datsina A. V. 
Published: July 2023

Mesenteric panniculitis (MPn) is a rare form of adipose tissue inflammation, mainly of the intestinal mesentery, less often of the omentum, preand retroperitoneal tissue. There are not many descriptions of MPn in rheumatic diseases in the literature: in systemic lupus erythematosus, systemic sclerosis, Sjogren's syndrome, rheumatoid arthritis (RA), ankylosing spondylitis, mesenteric form (MF) of idiopathic lobular panniculitis (ILPn) and IgG4-related disease (IgG4-RD). Given the polymorphism of clinical manifestations, including systemic ones, it is of interest to look at the problem of MPn from the perspective of a rheumatologist.Objective: to evaluate the clinical and laboratory features of MPn in modern rheumatological practice.Material and methods. The study included 64 patients (19 men and 45 women aged 19 to 76 years, median disease duration 28.6 [0.3; 243] months). Laboratory and instrumental studies were carried out according to a single algorithm, which included standard clinical, immunological methods, as well as the determination of fecal calprotectin and tumor markers, ultrasound of the skin and subcutaneous adipose tissue (SAT), computed tomography of the chest and abdominal organs, abdominal positron emission tomography, pathomorphological examination of biopsies of the skin, pancreas and mesentery.Results and discussion. 89% of patients had abdominal pain, 48.4% had nausea, 53.1% had weakness, 44% had subfebrile fever, 32.8% had articular syndrome, and 29.6% – skin and pancreas involvement. Median ESR was 34 [11; 52] mm/h, CRP level – 14 [2; 72] mg/l. Most of the immunological parameters remained within the normal range, but in some cases there was an increase in the concentration of rheumatoid factor, antibodies to the cyclic citrullinated peptide, IgG4. The level of tumor markers CA 125, CEA, CA 19–9 and TumorM2-PK was increased 2 times or more in 5 patients. In our study, all radiological signs and all degrees of severity of MPn were observed. An additional examination confirmed the presence of MF ILPn, RA, IgG4-RD, gastrointestinal, malignant, hematological and other diseases, which made it possible to identify five diagnostic blocks.Conclusion. Early diagnosis and correct interpretation of the described changes require a lot of work-up and a multidisciplinary approach, which contributes to accurate and timely recognition of the disease.
Catastrophic antiphospholipid syndrome: current aspects of pathogenesis, diagnosis and treatment
Authors: Klimenko A. A. , Gaffarova A. S. , Demidova N. A. 
Published: July 2023

Catastrophic antiphospholipid syndrome (CAPS) is a life-threatening condition associated with the development of thrombotic occlusion of microvasculature vessels, with a mortality rate of about 50%.The pathogenesis of CAPS is based on cellular activation, complement system induction, cytokine stimulation, inhibition of anticoagulant factors and fibrinolysis, which leads to progressive thrombotic microangiopathy, disseminated intravascular coagulation (DIC), and systemic inflammatory response syndrome. Classification criteria for CAPS include microthrombotic involvement of ≥3 organs (most commonly lungs, kidneys, and central nervous system) for ≤1 week with high titers of antiphospholipid antibodies.Differential diagnosis is carried out with DIC, heparin-induced thrombocytopenia, hemolytic uremic syndrome, HELLP syndrome, sepsis. Treatment of CAPS in the acute phase involves anticoagulant and immunosuppressive therapy (glucocorticoids, plasmapheresis, IV immunoglobulin, rituximab, eculizumab). Timely diagnosis and adequately selected treatment of CAPS can reduce mortality from 50 to 30%.Further study of CAPS is needed to improve the prognosis and increase the life expectancy of patients.
Switching biological disease-modifying antirheumatic drugs and Janus kinase inhibitors in patients with rheumatoid arthritis
Authors: Bobkova A. O. , Lila A. M. 
Published: July 2023

The goal of treatment of rheumatoid arthritis (RA) is to achieve remission or low disease activity. A wide range of disease-modifying antirheumatic drugs is used for the treatment of RA, including biological disease-modifying antirheumatic drugs (bDMARDs) and Janus kinase inhibitors (JAKi). However, even with the use of bDMARDs and JAKi, this goal can be achieved only in 40–60% of patients. Insufficient response to bDMARs and JAKi is the reason for switching to other drugs from the same group, such as tumor necrosis factor-α inhibitors, and to drugs with a different mechanism of action. The need to change therapy may be associated with its ineffectiveness due to various immune, genetic and epigenetic mechanisms, with the development of adverse reactions, as well as with comorbid pathology. To date, there is no certain predictors of effectiveness of a particular bDMARDs and JAKi and of the need and strategy for changing the therapy.The review considers the effectiveness of various classes of bDMARDs and JAKi in RA, the frequency and risk factors associated with the need to switch patients to other drugs, the role of chemokines as promising markers of response to RA treatment.
Diagnostic accuracy of extended HPV DNA genotyping and its application for risk-based cervical cancer screening strategy
Authors: Xie Hongyu , Rao Xuan , Li Junyan , Yao Lifang , Ji Ying , Zhang Juan , Wang Hui , Wang Xinyu , Li Xiao 
Published: July 2023

Abstract

Objectives
To evaluate the consistency of 14 high-risk HPVs (hr-HPVs) detection between extended HPV DNA genotyping and a well-validated partial HPV genotyping kit, and to explore the diagnostic accuracy of risk stratification strategy based on extended HPV genotyping for cervical cancer (CC) screening.

Methods
Baseline data from a clinical trial of recombinant HPV 9-valent vaccine in China was analyzed. All enrolled women aged 20–45 years received cervical cytology, HPV detection by extended and partial HPV genotyping kits. Those who met the indications would further receive colposcopy. The primary endpoints were cervical intraepithelial neoplasia 2/3 or worse (CIN2+/CIN3+).

Results
A total of 8,000 women were enrolled between April 2020 and July 2020 and 83/33 cases were diagnosed as CIN2+/CIN3+. The overall agreement between the extended and partial HPV genotyping was 92.66 %. And the agreement further increased with the progression of lesions, which lead to similarly high sensitivity and negative predictive value of these kits. A stratified triage strategy of CC screening was constructed based on the immediate CIN2+/CIN3+ risk of specific HPV. Compared with the conventional HPV primary CC screening strategy, the risk-based strategy had higher specificity for CIN (CIN2+: 94.84 vs. 92.46 %, CIN3+: 96.05 vs. 91.92 %), and needed fewer colposcopies for detecting one cervical disease.

Conclusions
Extended HPV genotyping had good agreement with a well-validated partial HPV genotyping CC primary screening kit in hr-HPV detection. Extended HPV genotyping could facilitate risk-based stratified management strategy and improve the diagnostic accuracy of primary CC screening.
A new online resource for chemical safety and green chemistry in science education
Authors: Tveit Svein , Faegri Karoline 
Published: July 2023

Abstract
Science and chemistry teachers often feel that they have insufficient knowledge about the legal requirements concerning proper handling of chemicals. To help teachers and technicians, we have developed an online resource with information and tools for the various aspects of chemical safety, such as legislation, risk assessment, storage, labelling and waste handling, including a framework for routines and training for staff and students. Additionally, the resource introduces the concept of green chemistry, an emerging field within chemistry education, and provides examples on how teachers could work with green chemistry principles in the science and chemistry classroom. The aim is that this extensive online material, covering the most important aspects of health, safety and environmental work in school science education, can serve as a useful resource for school leaders, teachers, technicians and science teacher educators in their work with these issues. The resource was developed by partners from the Universities of Helsinki, Ljubljana, Oslo, and Stockholm and co-funded by the Erasmus+ program of the European Union. The content is published in five languages and is freely available at https://chesse.org.
Enhancing learner motivation by adapting strategies from the ARCS model: experience from Chinese online course design and teaching
Authors: Song Chenqing , Kao Qifei 
Published: July 2023

Abstract
Compared with traditional language teaching in a face-to-face setting, online language teaching elicits new challenges that require instructors to adopt new strategies when designing and delivering online courses. One of the challenges, according to our literature review (Cull, S., Reed, D., & Kirk, K. (2010, June 23–25, 28–29). Student motivation and engagement in online courses [Workshop session]. In Teaching geoscience online – a workshop for digital faculty, Virtual workshop. https://serc.carleton.edu/NAGTWorkshops/online/motivation.html) and our instructors’ observations of online Chinese courses, was that college students suffered from loss of learning motivation, which impacted their learning experiences and outcomes, resulting in a downhill, vicious cycle. This paper discusses various adaptations that we designed to improve learner motivation by applying Keller’s ARCS model (Keller, J. M. (1983). Motivational design of instruction. In C. M. Reigeluth (Ed.), Instructional-design theories and models: An overview of their current status (pp. 383–434). Lawrence Erlbaum Associates, Keller, J. M. (1984). The use of the ARCS model of motivation in teacher training. Aspects of Educational Technology, 17, 140–145, Keller, J. M. (1987). Development and use of the ARCS model of instructional design. Journal of Instructional Development, 10(3), 2–10, Keller, J. M. (2010). Motivational design for learning and performance. Springer) during the process of (re)designing online Chinese courses from 2018 to 2020. Among many theories and models of learner motivation, Keller’s ARCS model stands out with its focus on instructional design, with four main practical categories: attention; relevance; confidence and satisfaction. This model further provides detailed subcategories for improving learner motivation, e.g., increasing variations in course material layout to capture students’ interest and providing real-time, encouraging feedback to enhance students’ beliefs in their competence. Our contextualised discussion of the ARCS model will benefit teachers and course designers seeking to enhance learner motivation in their online courses.
Möbius edge band and Weyl-like semimetal flat-band in topological photonic waveguide array by synthetic gauge flux
Authors: Liu Zhenzhen , Wei Guochao , Wu Huizhou , Xiao Jun-Jun 
Published: July 2023

Abstract
The presence of π gauge flux enabled by positive and negative hopping amplitude can lead to Möbius bands, which was recently demonstrated in both realistic acoustic and photonic lattices, twisted at k = π. Here, we show that the artificial gauge flux configuration can be achieved by exploiting the interactions between photonic s and p orbital-like fundamental modes in circular and peanut-shaped waveguides, respectively. By manipulating the interplay between the gauge fields and the crystal symmetry, we show that breaking the primitive translation symmetry through lattice site dimerization and deformation can cause the original Dirac semimetal phase, characterized by a four-fold Dirac point at the Brillouin zone center, to transform into various topological phases. The designed photonic waveguide array supports topological phases such as Möbius insulator and Weyl-like semimetal phases. Noticeably different to the existing cases, we explicitly show that the twisting Möbius bands cross each other at k = 0 due to the lattice gauging with alternating sign, which results in distinct beam dynamics excitation. We also present Weyl-like flat-band edge states in such photonics waveguide arrays. Our results suggest that such s − p hybridized photonic waveguide array servers as a convenient and flexible platform for studying topological physics, particularly in simulating the effects of gauge field in alternative configuration.
Exploring Must-know Criteria for Effective Customer Segmentation in Online Market Using AHP
Authors: Sekandari Elham , Aghaei Iman 
Published: July 2023

AbstractConsidering the advancement of technology, companies need to update their knowledge regarding consumer behavior and try to adapt to these changes to stay profitable. Therefore, this study aims to investigate the relative importance of market segmentation categories when assessing consumers’ online buying behavior. The data were collected through a standard AHP questionnaire from 71 individuals who lived in North Cyprus and have online shopping experience. The results were analyzed using the Analytic Hierarchy Process (AHP) methodology by Expert Choice software. Findings demonstrated that age, gender, and marital status are the most critical factors in determining online consumer behavior. However, group influence, adaptability, and brand loyalty were found to be the least important factors that can stimulate consumers to shop online. Managers are encouraged to target their consumers based on the essential categories since running marketing campaigns and advertising costs money and time. They can also benefit from the results of this study and apply more target-oriented segmentation strategies to enhance their companies’ performance. This paper provides a pioneering instrument to assess the relative importance of market segmentation categories in online market.
Die phänomenologischen Wurzeln der Gesprächsanalyse und das Politische bei Hannah Arendt: Ein Kombinationsvorschlag zur Analyse sprachlicher Interaktionen
Authors: Lindinger Isabel 
Published: July 2023

Abstract
Hannah Arendt's political theory remains influential in both the Humanities and the Social Sciences, including in sociology, educational sciences and political education. Arendt's works are utilized in different ways in these contexts. Within sociolinguistics and conversational linguistics, however, this does not seem to be the case. The present article aims to overcome this shortcoming by exploring opportunities for analytically integrating Arendt's understanding of the political and the conversation analysis point of view. Combining these two perspectives results in the added value of expanding the interpretive framework to include Arendt's dimensions of subjectivity, intersubjectivity, and access to the world. In line with this goal, the respective phenomenological influences of both approaches, Arendt’s political theory and the phenomenological precursors of conversation analysis, are considered separately. After providing an overview of the phenomenological roots for socio- and conversation analysis (Edmund Husserl, Alfred Schütz, Harold Garfinkel), Arendt's concept of the political is discussed. Subsequently, the analytical nexus of the approaches are elaborated on in the form of three theses. It is argued that Arendt developed an innovative phenomenological concept of plurality which has the potential of forming the basis for an interpretive tool for the analysis of oral interaction (in line with Garfinkel’s ethnomethodology).
Measurement Properties of Patient Reported Outcome Scales: A Systematic Review
Authors: Stallwood Emma , Elsman Ellen B.M. , Monsour Andrea , Baba Ami , Butcher Nancy J. , Offringa Martin 
Published: July 2023

CONTEXTRecently a standard set for overall pediatric health outcomes in routine care was developed, which includes patient (or proxy) reported outcome measures (PROMs) for global health, cognitive functioning, and self-efficacy.OBJECTIVESTo determine whether the following PROMs have sufficient measurement properties to be used in pediatric routine care: PROMIS Pediatric and Parent Proxy Scale - Global Health 7+2, PROMIS Parent Proxy Short Form - Cognitive Function 7a, and NIH Toolbox Self-Efficacy CAT Ages 13 to 17.DATA SOURCESEmbase, Psych INFO, and Web of Science were searched from year of inception of each PROM to May 25, 2020; Medline to October 24, 2022.STUDY SELECTIONEnglish, full-text peer-reviewed articles that evaluated measurement properties of included PROMs were eligible.DATA EXTRACTIONThe COSMIN guideline for systematic reviews was used to appraise eligible studies and synthesize the overall evidence.RESULTSScreening &gt;4000 titles yielded 4 to 6 eligible empirical studies for each PROM. The PROMIS instruments had sufficient content validity with low-quality evidence and at least low-quality evidence for sufficient structural validity and internal consistency. The NIH Toolbox lacked essential evidence for content validity.LIMITATIONSAssessments of measurement properties were based on information reported in the included studies; underreporting might have led to less favorable ratings.CONCLUSIONSThe PROMIS instruments assessed in this review measure their intended construct for their targeted age group; clinicians can use these PROMs in pediatric routine care. Additional studies evaluating measurement properties, including content validity, are needed for the NIH Toolbox before it should be recommended for use in clinical practice.
Embodied Inequalities of the Anthropocene
Authors: Segata Jean , Víctora Ceres , Sesia Paola , Montesi Laura , Gamlin Jennie , Gibbon Sahra 
Published: July 2023

Introduction to the special issue 'Embodied Inequalities of the Anthropocene', guest edited by Jennie Gamlin, Laura Montesi, Sahra Gibbon, Paola Sesia, Jean Segata, and Ceres Victora.
Ugi 5-center-4-component reaction of α-Amino Aldehydes/Deprotection/Cyclization sequence leading to substituted 2-oxopiperazine derivatives
Authors: Splandesci Marta , Wróbel Martyna Z. , Madura Izabela D. , Dawidowski Maciej 
Published: July 2023

Abstract
A synthetic route leading to densely functionalized 2-oxopiperazine derivatives is presented. The strategy employs a 5-center-4-component variant of Ugi multicomponent reaction followed by a deprotection/cyclization sequence. N-Boc-α-amino aldehydes were used for the first time as carbonyl components in a key Ugi 5-center-4-compent reaction (U-5C-4CR). It is shown that the presented synthetic route can lead to rigid, heterocyclic scaffolds, as demonstrated by the synthesis of tetrahydro-2H-pyrazino[1,2-a]pyrazine-3,6,9(4H)-trione β-turn mimetic and derivatives of 1,6-dioxooctahydropyrrolo[1,2-a]pyrazine and 3,8-dioxohexahydro-3H-oxazolo[3,4-a]pyrazine.
Species invasion alters fish mercury biomagnification rates
Authors: Rennie Michael , James Leah A. H. , Arnott Shelley E. , Casselman John M. , Evans David O. , Sprules W. Gary 
Published: July 2023

Abstract
Bythotrephes cederströemi have invaded numerous inland lakes in North America, many of which are stratified and support offshore fishes like the Cisco (Coregonus artedi). While evaluations based on changes in zooplankton community composition following Bythotrephes invasion predict an increase in Cisco mercury concentrations, this phenomenon was not detected from a survey evaluating temporal changes in Cisco Hg across a broad range of lakes varying in the presence or absence of Bythotrephes. Here, we compare temporal changes in Cisco biomagnification factor slopes (i.e., slopes of relationships between Cisco Hg and δ15N isotopes) from lakes experiencing Bythotrephes invasion over the study period to those already invaded (as a reference) over similar time periods. Our results show that biomagnification slopes after Bythotrephes invasion either changed direction entirely (from positive to negative relationships) or decreased in elevation relative to those prior to invasion. No such pattern was observed in previously invaded reference lakes. Reductions in Cisco biomagnification slopes and/or intercepts following Bythotrephes invasion suggest that conversion efficiency (and therefore growth) of Cisco increased after invasion (i.e., less Hg accumulates in fish at an equivalent trophic position after vs. before invasion). Back-calculated Cisco growth rates and size-at-age were greater in the presence of Bythotrephes than without, further supporting the hypothesis that changes in Hg biomagnification are likely due to increased conversion efficiency. These findings highlight the potential importance of foraging energetics over and above shifts in trophic position in modifying fish contaminant concentrations.