bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harnessing adaptive bistable stiffness of hair-cell-bundle structure for broadband vibration applications
Authors: Yoon Jong-Yun , Kim Gi-Woo 
Published: July 2023

AbstractThis study presents an initial study on the adaptive bistable stiffness of the hair cell bundle structure in a frog cochlea, and aims to harness its bistable nonlinearity that features a negative stiffness region for broadband vibration applications such as vibration-based energy harvesters. To this end, the mathematical model for describing the bistable stiffness is first formulated based on the modeling concept of piecewise type nonlinearities. The harmonic balance method was then employed to examine the nonlinear responses of bistable oscillator, mimicking hair cells bundle structure under the frequency sweeping condition, and their dynamic behaviors induced by bistable stiffness characteristics are projected on phase diagrams, and Poincare maps concerning the bifurcation. In particular, the bifurcation mapping at the super- and sub-harmonic regimes provides a better perspective to examine the nonlinear motions which occur in the biomimetic system. The use of bistable stiffness characteristics of hair cell bundle structure in frog cochlea thus offers physical insights to harness the adaptive bistable stiffness for metamaterial-like potential engineering structures such as vibration-based energy harvester, and isolator etc.
Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival
Authors: Kotnik Emilee N. , Mullen Mary M. , Spies Nicholas C. , Li Tiandao , Inkman Matthew , Zhang Jin , Martins-Rodrigues Fernanda , Hagemann Ian S. , McCourt Carolyn K. , Thaker Premal H. , Hagemann Andrea R. , Powell Matthew A. , Mutch David G. , Khabele Dineo , Longmore Gregory D. , Mardis Elaine R. , Maher Christopher A. , Miller Christopher A. , Fuh Katherine C. 
Published: July 2023

AbstractHigh-grade serous ovarian cancer (HGSC) is the most lethal histotype of ovarian cancer and the majority of cases present with metastasis and late-stage disease. Over the last few decades, the overall survival for patients has not significantly improved, and there are limited targeted treatment options. We aimed to better characterize the distinctions between primary and metastatic tumors based on short- or long-term survival. We characterized 39 matched primary and metastatic tumors by whole exome and RNA sequencing. Of these, 23 were short-term (ST) survivors (overall survival (OS) < 3.5 years) and 16 were long-term (LT) survivors (OS > 5 years). We compared somatic mutations, copy number alterations, mutational burden, differential gene expression, immune cell infiltration, and gene fusion predictions between the primary and metastatic tumors and between ST and LT survivor cohorts. There were few differences in RNA expression between paired primary and metastatic tumors, but significant differences between the transcriptomes of LT and ST survivors in both their primary and metastatic tumors. These findings will improve the understanding of the genetic variation in HGSC that exist between patients with different prognoses and better inform treatments by identifying new targets for drug development.
Symmetry breaking in core-valence double ionisation of allene
Authors: Ideböhn Veronica , Linguerri Roberto , Cornetta Lucas M. , Olsson Emelie , Wallner Måns , Squibb Richard J. , Couto Rafael C. , Karlsson Leif , Nyman Gunnar , Hochlaf Majdi , Eland John H. D. , Ågren Hans , Feifel Raimund 
Published: July 2023

AbstractConventional electron spectroscopy is an established one-electron-at-the-time method for revealing the electronic structure and dynamics of either valence or inner shell ionized systems. By combining an electron-electron coincidence technique with the use of soft X-radiation we have measured a double ionisation spectrum of the allene molecule in which one electron is removed from a C1s core orbital and one from a valence orbital, well beyond Siegbahns Electron-Spectroscopy-for-Chemical-Analysis method. This core-valence double ionisation spectrum shows the effect of symmetry breaking in an extraordinary way, when the core electron is ejected from one of the two outer carbon atoms. To explain the spectrum we present a new theoretical approach combining the benefits of a full self-consistent field approach with those of perturbation methods and multi-configurational techniques, thus establishing a powerful tool to reveal molecular orbital symmetry breaking on such an organic molecule, going beyond Löwdins standard definition of electron correlation.
Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response
Authors: Savchenko Viktoriia , Szamosvári Dávid , Bao Yifan , Pignitter Marc , Böttcher Thomas 
Published: July 2023

AbstractThe human pathogen Pseudomonas aeruginosa produces various 4(1H)-quinolones with diverse functions. Among these, 2-nonyl-4(1H)-quinolone (NQ) and its N-oxide (NQNO) belong to the main metabolites. Their biosynthesis involves substrates from the fatty acid metabolism and we hypothesized that oxidized fatty acids could be responsible for a so far undetected class of metabolites. We developed a divergent synthesis strategy for 2′-hydroxy (2′-OH) and 2′-oxo- substituted quinolones and N-oxides and demonstrated for the first time that 2′-OH-NQ and 2′-OH-NQNO but not the corresponding 2′-oxo compounds are naturally produced by PAO1 and PA14 strains of P. aeruginosa. The main metabolite 2′-OH-NQ is produced even in concentrations comparable to NQ. Exogenous availability of β-hydroxydecanoic acid can further increase the production of 2′-OH-NQ. In contrast to NQ, 2′-OH-NQ potently induced the cytokine IL-8 in a human cell line at 100 nм, suggesting a potential role in host immune modulation.
Insect diversity is a good indicator of biodiversity status in Africa
Authors: Landmann Tobias , Schmitt Michael , Ekim Burak , Villinger Jandouwe , Ashiono Faith , Habel Jan C. , Tonnang Henri E. Z. 
Published: July 2023

AbstractReliable metrics to monitor human impacts on biodiversity are essential for informing conservation policy. As insects are indicators of global change, whose declines profoundly affect ecosystems, insect diversity may predict biodiversity status. Here we present an unbiased and straightforward biodiversity status metric based on insect diversity (richness) and landscape naturalness. Insect diversity was estimated using spatially explicit earth observation data and insect species assemblages across microhabitats in two agro-ecological zones in Africa. Landscape naturalness was estimated using various human impact factors. Biodiversity status values differed considerably (p < 0.05) between protected and non-protected areas, while protected areas, regardless of agro-ecology, shared similar biodiversity status values. The metric is consistent when using richness from different indicator taxa (i.e., stingless bees, butterflies, dragonflies) and independent data for landscape naturalness. Our biodiversity status metric is applicable to data-scarce environments and practical for conservation actions and reporting the status of biodiversity targets.
Grassland carbon-water cycling is minimally impacted by a photovoltaic array
Authors: Kannenberg Steven A. , Sturchio Matthew A. , Venturas Martin D. , Knapp Alan K. 
Published: July 2023

AbstractAgrivoltaic systems, whereby photovoltaic arrays are co-located with crop or forage production, can alleviate the tension between expanding solar development and loss of agricultural land. However, the ecological ramifications of these arrays are poorly known. We used field measurements and a plant hydraulic model to quantify carbon-water cycling in a semi-arid C3 perennial grassland growing beneath a single-axis tracking solar array in Colorado, USA. Although the agrivoltaic array reduced light availability by 38%, net photosynthesis and aboveground net primary productivity were reduced by only 6–7% while evapotranspiration decreased by 1.3%. The minimal changes in carbon-water cycling occurred largely because plant photosynthetic traits underneath the panels changed to take advantage of the dynamic shading environment. Our results indicate that agrivoltaic systems can serve as a scalable way to expand solar energy production while maintaining ecosystem function in managed grasslands, especially in climates where water is more limiting than light.
Longevity factor klotho enhances cognition in aged nonhuman primates
Authors: Castner Stacy A. , Gupta Shweta , Wang Dan , Moreno Arturo J. , Park Cana , Chen Chen , Poon Yan , Groen Aaron , Greenberg Kenneth , David Nathaniel , Boone Tom , Baxter Mark G. , Williams Graham V. , Dubal Dena B. 
Published: July 2023

AbstractCognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans.
Loss of allosteric regulation in α-isopropylmalate synthase identified as an antimicrobial resistance mechanism
Authors: Sullivan Jaryd R. , Courtine Christophe , Taylor Lorne , Solomon Ori , Behr Marcel A. 
Published: July 2023

AbstractDespite our best efforts to discover new antimicrobials, bacteria have evolved mechanisms to become resistant. Resistance to antimicrobials can be attributed to innate, inducible, and acquired mechanisms. Mycobacterium abscessus is one of the most antimicrobial resistant bacteria and is known to cause chronic pulmonary infections within the cystic fibrosis community. Previously, we identified epetraborole as an inhibitor against M. abscessus with in vitro and in vivo activities and that the efficacy of epetraborole could be improved with the combination of the non-proteinogenic amino acid norvaline. Norvaline demonstrated activity against the M. abscessus epetraborole resistant mutants thus, limiting resistance to epetraborole in wild-type populations. Here we show M. abscessus mutants with resistance to epetraborole can acquire resistance to norvaline in a leucyl-tRNA synthetase (LeuRS) editing-independent manner. After showing that the membrane hydrophobicity and efflux activity are not linked to norvaline resistance, whole-genome sequencing identified a mutation in the allosteric regulatory domain of α-isopropylmalate synthase (α-IPMS). We found that mutants with the α-IPMSA555V variant incorporated less norvaline in the proteome and produced more leucine than the parental strain. Furthermore, we found that leucine can rescue growth inhibition from norvaline challenge in the parental strain. Our results demonstrate that M. abscessus can modulate its metabolism through mutations in an allosteric regulatory site to upregulate the biosynthesis of the natural LeuRS substrate and outcompete norvaline. These findings emphasize the antimicrobial resistant nature of M. abscessus and describe a unique mechanism of substrate-inhibitor competition.
Spontaneous Hemothorax by Pulmonary Arteriovenous Malformation during Pregnancy
Authors: Duan Chuxiao , Mu Yunfei , Yang Yi 
Published: July 2023

Abstract
Background: Pulmonary arteriovenous malformation (PAVM) is a rare vascular malformation that may cause hemothorax, especially during pregnancy.
Case Description: A 25-year-old woman presented sudden-onset left chest pain, dizziness, and dyspnea in the 27th week of gestation. Computed tomography angiography showed left pleural effusion with complete hemithorax opacification and an aneurysmal PAVM. She exhibited hemorrhagic shock and received emergency exploratory video-assisted thoracic surgery. A ruptured PAVM was identified and stopped by wedge resection in the upper lobe of the left lung. The patient's postoperative clinical course was uncomplicated. She subsequently delivered a healthy live baby vaginally at 41 weeks gestation.
Conclusion: PAVM should be considered in pregnant women with hemothorax. Emergency thoracoscopic surgery is the best treatment option.
Breast Reconstruction after Blunt Breast Trauma: Systematic Review and Case Report Using the Ribeiro Technique
Authors: Mayer Horacio F. , Huatuco René M. Palacios , Ramírez Mariano F. , Buena Ignacio T. Piedra 
Published: July 2023

AbstractBlunt breast trauma occurs in 2% of blunt chest injuries. This study aimed to evaluate the evidence on breast reconstruction after blunt trauma associated with the use of a seat belt. Also, we describe the first case of breast reconstruction using the Ribeiro technique. In November 2022, a systematic search of MEDLINE, EMBASE, and Google Scholar databases was conducted. The literature was screened independently by two reviewers, and the data was extracted. Our search terms included breast, mammoplasty, blunt injury, and seat belts. In addition, we present the case of a woman with a left breast deformity and her reconstruction using the inferior Ribeiro flap technique. Six articles were included. All included studies were published between 2010 and 2021. The studies recruited seven patients. According to the Teo and Song classification, seven class 2b cases were reported. In five cases a breast reduction was performed in the deformed breast with different types of pedicles (three superomedial flaps, one lower flap, one superior flap). Only one case presented complications. The case here presented was a type 2b breast deformity in which the lower Ribeiro pedicle was used successfully without complications during follow-up. Until now there has been no consensus on reconstructive treatment due to the rarity of this entity. However, we must consider surgical treatment individually for each patient. We believe that the Ribeiro technique is a feasible and safe alternative in the treatment of posttraumatic breast deformities, offering very good long-term results.
A Photoinduced Palladium-Catalyzed Cascade Reaction for the Synthesis of Chiral Piperidines with Chiral Amino Acid Derivatives and 1,3-Dienes
Authors: Song Shun , Yin Yi-Zhuo , Han Zhi-Yong 
Published: July 2023

AbstractA photoinduced palladium-catalyzed cascade reaction involving remote C(sp3)–H functionalization and intramolecular Tsuji–Trost annulation is developed. The reaction is proposed to proceed through a sequence involving the amidyl radical generation, 1,5-HAT-mediated alkyl radical formation, and subsequent difunctionalization of 1,3-dienes. Without the use of exogeneous photosensitizers and external oxidants, the reaction provided an efficient approach to multi-substituted chiral piperidines in high yields, employing readily available chiral amino acid derivatives and 1,3-dienes as the substrates. In most cases, the syn/anti ratio of the product could be further improved by treatment with catalytic amount of iron salt.
Career Satisfaction and Burnout among American Muslim Physicians
Authors: Al Sad Sondos , Padela Aasim I. 
Published: July 2023

Abstract
Background Career satisfaction and burnout among physicians are important to study because they impact healthcare quality, outcomes, and physicians' well-being. Relationships between religiosity and these constructs are underexplored, and Muslim American physicians are an understudied population.
Methods To explore relationships between career satisfaction, burnout, and callousness and Muslim physician characteristics, a questionnaire including measures of religiosity, career satisfaction, burnout, callousness, and sociodemographic characteristics was mailed to a random sample of Islamic Medical Association of North America members. Statistical relationships were explored using chi-squared tests and logistic regression models.
Results There were 255 respondents (41% response rate) with a mean age of 52 years. Most (70%) were male, South Asian (70%), and immigrated to the United States as adults (65%). Nearly all (89%) considered Islam the most or very important part of their life, and 85% reported being somewhat or very satisfied with their career. Multivariate models revealed that workplace accommodation of religious identity is the strongest predictor of career satisfaction (odds ratio [OR]: 2.69, p = 0.015) and that respondents who considered religious practice to be the most important part of their lives had higher odds of being satisfied with their career (OR: 2.21, p = 0.049) and lower odds of burnout (OR: 0.51, p = 0.016). Participants who felt that their religion negatively influenced their relationships with colleagues had higher odds of callousness (OR: 2.25, p = 0.003).
Conclusions For Muslim physicians, holding their religion to be the most important part of their life positively associates with career satisfaction and lower odds of burnout and callousness. Critically, perceptions that one's workplace accommodates a physician's religious identity associate strongly with career satisfaction. In this era of attention to physician well-being, the importance of religiosity and religious identity accommodations to positive career outcomes deserves focused policy attention.
Metacarpophalangeal Joint Arthroscopy: Indications and Techniques through a Clinical Series
Authors: Tovar-Bazaga Miguel , Pérez-Cuesta Llaneras María , Badia Alejandro 
Published: July 2023

Abstract
Background Metacarpophalangeal (MCP) joint arthroscopy has been available for many years but sparingly used in typical orthopaedic and hand surgery daily practice. Difficult problems are solved with this technique in a practical and minimally invasive manner. This study describes our diverse experience and broad clinical applications of MCP arthroscopy as well as clinical results. It aims to highlight this technique as one of the tools for a fully trained hand surgeon, avoiding open management and its high complications rates.
Methods We present a retrospective clinical series of 79 patients treated with MCP arthroscopy with a mean age of 44 years old. Demographics, surgery, and clinical outcomes were collected in standardized clinical assessments.
Results We divided the sample into 20 articular metacarpal or proximal phalanx acute fracture with full functional fist and range of motion at 60 days after surgery. Regarding collateral tears, 12 were classified as acute and 47 as chronic. Two patients were reoperated for further gain range of motion.
Conclusions We present an up-to-date publication of our experience in MCP arthroscopy and its applications, with a low complication rate and excellent clinical results. We encourage hand surgeons to incorporate this technique in MCP joint challenging issues.
Level of Evidence IV
The untranslatability of Literaturnost revisited in the era of artificial intelligence
Authors: Lei Han 
Published: July 2023

Abstract
This paper revisits Roman Jakobson’s literaturnost within the framework of modern poetics and in light of the challenge posed by artificial intelligence to human literary translation. It is argued that literary translation is, in essence, more of a project of code transposition and meaning generation than of message transmission. Furthermore, it is noted that although algorithms can process certain literary devices, they are currently unable to process the polysystemic relations that constitute an artwork’s literaturnost. Consequently, it is emphasized that meaning transferal, meaning generation, and the revolt against meaning will continue to pose barriers for future machine translation even in the long term.
Release of Arabidopsis seed dormancy by cold atmospheric plasma relies on cytoplasmic glass transition
Authors: August Jonas , Dufour Thierry , Bailly Christophe 
Published: July 2023

Abstract
When mature Arabidopsis thaliana seeds are dormant, their germination is prevented in apparently favorable conditions. This primary dormancy can be released during seed dry storage through a process called after-ripening whose duration can last several months. To reduce this delay, cold atmospheric plasmas (CAPs) can be used as sources of reactive oxygen species (ROS) capable of inducing heterogeneous chemical reactions. While CAP are known to stimulate the germination of various seed species, the relationship between CAP treatments and the amorphous solid state of dry seeds remains unexplored. Here, we demonstrate that seed dormancy can be alleviated using a cold plasma of ambient air and that this alleviation can be amplified for seeds with high water-content (typically 30%DW) or seeds heated at 60 °C during plasma treatment. Differential scanning micro-calorimetry shows that these characteristics control the glassy/rubbery state of the seed cytoplasm. This technique indicates also that a glass transition to the rubbery state strengthens the CAP effects to alleviate seed dormancy. We propose that lower cytoplasmic viscosity can promote the oxidative signaling induced by CAP which, in turn, improves the germination process.
Thomson scattering measurements of electron temperature and electron density in laser-driven Gd plasmas
Authors: Pan Yiming , Sunahara Atsushi , Namba Shinichi , Higashiguchi Takeshi , Tomita Kentaro 
Published: July 2023

Abstract
In this study, we demonstrate the laser intensity scaling of electron temperature in Gd laser-produced plasmas (LPPs) through experiment and simulation. The spatial and temporal profiles of electron density ne
and temperature Te
in Gd LPPs were directly measured during a drive laser pulse duration of 7 ns at a laser wavelength of 1064 nm using collective Thomson scattering. We found that the measured maximum Te
value in Gd LPPs increases with increasing laser intensity IL
, with the dependence

T
e

∝

I
L

0.37

, in the IL
range of 1010–

10

11

W

⋅

c
m

−
2

. Radiation-hydrodynamic simulation code of the STAR-2D was performed under identical conditions to those used in the experiment, and extended further to higher laser intensities of up to

6
×

10

11

W

⋅

c
m

−
2

; the simulated Te
was found to be in good agreement with the experimental data over the used IL
range. The simulation indicates that higher overall maximum Te
typically exists 50–70

μ

m

above the target and modifies the dependence as

T
e

∝

I
L

0.44

. Experiments reveal that a laser intensity of

1.9
×

10

12

W

⋅

c
m

−
2

is required to achieve the optimum condition (

T
e

∼

100 eV and ion charge states

∼

G
d

18
+

, at

n
e

∼
(
2

–

3
)
×

10

19

c
m

−
3

) for efficient beyond extreme ultraviolet (EUV) light source. In addition, two spot sizes (150 and 250

μ

m

in diameter) were used to study the effect of the spot size on the Te
profile. Our experimental findings, supported by the simulations, show that larger spots can create uniform Te
profiles, higher maximum Te
, and larger high-Te
regions in LPPs. The results and scaling laws presented in this study provide important information for developing more powerful and energy-efficient EUV light sources.