bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Mammography Screening Frequency and Breast Cancer Treatment and Outcomes: A Retrospective Cohort Study
Authors: Liu Ying , Gordon Aliza S , Eleff Michael , Barron John J , Chi Winnie C 
Published: January 2023

Abstract

Objective
Guidelines for optimal frequency of screening mammography vary by professional society. Sparse evidence exists on the association between screening frequency and breast cancer treatment options. The main objective was to examine differences in cancer treatment rendered for U.S. women with different numbers of screenings prior to breast cancer diagnosis. Cancer stage at diagnosis and health care cost were assessed in secondary analyses.

Methods
This IRB-exempt retrospective study used administrative claims data to identify women aged 44 or older with various numbers of mammographic screenings ≥11 months apart, during the four years prior to incident breast cancer diagnosis from January 2010 to December 2018. Outcomes were assessed over the six months following diagnosis. Generalized linear regression models were used to compare women with differing numbers of mammograms, adjusting for patient characteristics.

Results
Claims data review identified 25 492 women who met inclusion criteria. There was a stepwise improvement in each of these screening categories such that women with four screenings, compared to women with only one screening, experienced higher rates of lumpectomy (70% vs 55%) and radiation therapy (48% vs 36%), lower rates of mastectomy (27% vs 34%) and chemotherapy (28% vs 36%), less stage 3 or 4 cancer at diagnosis (15% vs 29%), and lower health care costs within six months postdiagnosis (P &lt; 0.001). Results were similar in a subgroup limited to women aged 44 to 49 at diagnosis.

Conclusion
Potential benefits of more frequent screening include less aggressive treatment and lower health care costs among women who develop breast cancer.
Diagnostic Contrast-Enhanced Mammography Performed Immediately Prior to Same-Day Biopsy: An Analysis of Index Lesion Enhancement Compared to Histopathology and Follow-up in Patients With Suspicious Ultrasound Findings
Authors: Emory Tim , Hoven Noelle , Nelson Michael , Church An L , Rubin Nathan , Kuehn-Hajder Jessica 
Published: January 2023

Abstract

Objective
To measure the diagnostic performance of contrast-enhanced mammography (CEM) for the index lesion when it is performed the same day prior to biopsy in patients with suspicious findings at US.

Methods
This IRB-approved retrospective study compared radiologist original reports of the presence or absence of index lesion enhancement on CEM to biopsy results and follow-up. The most suspicious lesion or the larger of equally suspicious lesions recommended for biopsy by US after a diagnostic workup including mammography was considered the index lesion. CEM exams were performed the same day, immediately prior to the scheduled biopsy, as requested by the radiologist recommending the biopsy. Numeric variables were summarized with means and standard deviations, or medians and the minimum and maximum, where appropriate.

Results
Biopsy demonstrated cancer in 64.7% (200/309) of index lesions. Of these, 197/200 demonstrated enhancement for a sensitivity of 98.5% (95% CI: 95.7%–99.7%) (197/200) and the negative predictive value of CEM for non-enhancing index lesions was 95.1% (58/61; 95% CI: 86.1%–98.4%). The three false negative exams were two grade 1 ER+ HER2− invasive ductal cancers that were 6 mm and 7 mm in size, and a 3-mm grade 2 ductal carcinoma in situ in a complex cystic and solid mass. False positive exams made up 20.6% (51/248) of the positive exams.

Conclusion
Diagnostic CEM showed high sensitivity and specificity for cancer in lesions with suspicious US findings. CEM may reduce the need for some biopsies, and negative CEM may support a true negative biopsy result.
Multifocal demyelinating leukoencephalopathy and oligodendroglial lineage cell loss with immune effector cell-associated neurotoxicity syndrome (ICANS) following CD19 CAR T-cell therapy for mantle cell lymphoma
Authors: Nie Esther H , Ahmadian Saman S , Bharadwaj Sushma N , Acosta-Alvarez Lehi , Threlkeld Zachary D , Frank Matthew J , Miklos David B , Monje Michelle , Scott Brian J , Vogel Hannes 
Published: January 2023

Abstract
Immune effector cell-associated neurotoxicity syndrome (ICANS) is a prevalent condition seen after treatment with chimeric antigen receptor T-cell (CAR T) therapy and other cancer cell therapies. The underlying pathophysiology and neuropathology of the clinical syndrome are incompletely understood due to the limited availability of brain tissue evaluation from patient cases, and a lack of high-fidelity preclinical animal models for translational research. Here, we present the cellular and tissue neuropathologic analysis of a patient who experienced grade 4 ICANS after treatment with anti-CD19 CAR T therapy for mantle cell lymphoma. Our pathologic evaluation reveals a pattern of multifocal demyelinating leukoencephalopathy associated with a clinical course of severe ICANS. A focused analysis of glial subtypes further suggests region-specific oligodendrocyte lineage cell loss as a potential cellular and pathophysiologic correlate in severe ICANS. We propose a framework for the continuum of neuropathologic changes thus far reported across ICANS cases. Future elucidation of the mechanistic processes underlying ICANS will be critical in minimizing neurotoxicity following CAR T-cell and related immunotherapy treatments across oncologic and autoimmune diseases.
Effects of lymphopenia on survival in proton therapy with chemotherapy for non-small cell lung cancer
Authors: Nakamura Masatoshi , Ishikawa Hitoshi , Ohnishi Kayoko , Mori Yutarou , Baba Keiichiro , Nakazawa Kensuke , Shiozawa Toshihiro , Sekine Ikuo , Maruo Kazushi , Okumura Toshiyuki , Sakurai Hideyuki 
Published: January 2023

AbstractLymphocytes play an important role in the cancer immune system. In the present study, we aimed to evaluate the associations of lymphopenia during proton beam therapy (PBT) and concurrent chemotherapy with clinical outcomes and to determine whether lung or bone is more influential on lymphopenia during PBT. Data from 41 patients with stage III non-small cell lung cancer (NSCLC) who received PBT of 74 GyE with concurrent chemotherapy between 2007 and 2017 were reviewed retrospectively. The correlation between dosimetry parameters obtained from dose–volume histograms of the bone and lung and lymphopenia during PBT were analyzed. Minimum absolute lymphocyte count (ALCmin) and maximum neutrophil/lymphocyte ratio (NLRmax) were used as indicators of lymphopenia. Bone V5–20 and lung V5–50 were significantly correlated with the ALCmin and NLRmax during PBT. Multivariable analysis showed that the NLRmax, but not the ALCmin, was associated with overall survival (OS), progression-free survival (PFS) and distant metastasis-free survival (DMFS). The 3-year rates of OS, PFS and DMFS of patients with a low (≤ 6.3) versus high (&gt; 6.3) NLRmax were 73.9% vs 44.4% (P = 0.042), 26.1% vs 5.6% (P = 0.022) and 39.1% vs 5.6% (P &lt; 0.001), respectively. Lung V20 was significantly associated with DMFS on multivariable analyses (hazard ratio: 1.094, P = 0.008), whereas bone V5 had no impact on survival outcomes. We concluded that the NLRmax was a better prognostic indicator than the ALCmin, and the lung dose had more influence than the bone dose on the main survival outcomes in stage III NSCLC patients treated with PBT combined with concurrent chemotherapy.
Prospective cohort study of electrodiagnostic abnormality characterization in pronator quadratus associated with end-to-side nerve transfers for ulnar neuropathy at the elbow
Authors: Rathagirishnan Raahulan , Ritsma Benjamin , Trier Jessica , Daneshvar Parham , Hendry Michael 
Published: January 2023

AbstractUlnar neuropathy at the elbow (UNE) is a common compressive neuropathy that affects the median nerve. Conservative management for mild-to-moderate UNE is an important first step, but generally, develops a plateau in benefit. A specific technique, referred to as a supercharged ‘end-to-side’ (SETS) nerve transfer can successfully restore pinch, fine motor dexterity and grip strength. A pre-surgical workup flow for UNE patients has been developed, which includes electrodiagnostic (EDX) studies completed to assess the recipient ulnar nerve and the donor median nerve to pronator quadratus (PQ). There is little evidence that the assessment of the PQ muscle is necessary in a non-traumatic setting. A prospective cohort study of patients who present with clinical and/or EDX evidence of ulnar compressive neuropathy, with clinical evidence of motor dysfunction, was assessed for health PQ donor in routine pre-operative workup. We aim to provide justification that SETS for UNE should not be delayed to acquire PQ EDX studies.
Wnt signaling regulates MFSD2A-dependent drug delivery through endothelial transcytosis in glioma
Authors: Xie Yuan , He Liqun , Zhang Yanyu , Huang Hua , Yang Fan , Chao Min , Cao Haiyan , Wang Jianhao , Li Yaling , Zhang Lingxue , Xin Lele , Xiao Bing , Shi Xinxin , Zhang Xue , Tang Jiefu , Uhrbom Lene , Dimberg Anna , Wang Liang , Zhang Lei 
Published: January 2023

Abstract

Background
Systemic delivery of anti-tumor therapeutic agents to brain tumors is thwarted by the blood-brain barrier (BBB), an organotypic specialization of brain endothelial cells (ECs). A failure of pharmacological compounds to cross BBB is one culprit for the dismal prognosis of glioblastoma (GBM) patients. Identification of novel vascular targets to overcome the challenges posed by the BBB in tumors for GBM treatment is urgently needed.

Methods
Temozolomide (TMZ) delivery was investigated in CT2A and PDGFB-driven RCAS/tv-a orthotopic glioma models. Transcriptome analysis was performed on ECs from murine gliomas. Mfsd2a deficient, Cav1 deficient, and Mfsd2a EC-specific inducible mice were developed to study the underlying molecular mechanisms.

Results
We demonstrated that inhibiting Wnt signaling by LGK974 could increase TMZ delivery and sensitize glioma to chemotherapy in both murine glioma models. Transcriptome analysis of ECs from murine gliomas revealed that Wnt signaling inhibition enhanced vascular transcytosis as indicated by the upregulation of PLVAP and downregulation of MFSD2A. Mfsd2a deficiency in mice enhances TMZ delivery in tumors, whereas constitutive expression of Mfsd2a in ECs suppresses the enhanced TMZ delivery induced by Wnt pathway inhibition in murine glioma. In addition, Wnt signaling inhibition enhanced caveolin-1 (Cav1)-positive caveolae-mediated transcytosis in tumor ECs. Moreover, Wnt signaling inhibitor or Mfsd2a deficiency fails to enhance TMZ penetration in tumors from Cav1-deficient mice.

Conclusions
These results demonstrated that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated EC transcytosis pathway. Our findings identify Wnt signaling as a promising therapeutic target to improve drug delivery for GBM treatment.
ASSESSMENT OF OCCUPATIONAL EXPOSURE TO EXTERNAL RADIATION AMONG WORKERS OF THREE COMMUNITY HOSPITALS IN SENEGAL
Authors: Niang Modou , Senghor Cheikh , Ndoye Fatou , Fall El Hadji Mamadou , Faye Ndeye Arame Boye 
Published: January 2023

AbstractOccupational radiation doses of 602 medical workers from the departments of Radiology, Thoracic and cardiovascular surgery, Operating room, Nuclear medicine, Radiotherapy and cardiology were evaluated during 2017 to 2021 in three hospitals in Senegal. Each hospital was subdivided into various occupational groups. Whole-body doses Hp(10), local skin doses Hp(0.07) and annual collective dose Hp(10) were measured by OSL (optically stimulated luminescence) dosimetry. The occupational groups with the highest radiation exposures, ~0.185 mSv in 1 y, were in the field of nuclear medicine, radiology, cardiology, Thoracic and cardiovascular surgery and Operating room. All results of the measured annual effective dose were below the ICRP (International Commission on Radiological Protection) dose limits of 20 mSv/y, averaged over any 5-y period.
UTERINE DOSE CONVERSION COEFFICIENTS FOR EXTERNAL PHOTONS FOR THE TAIWANESE PREGNANT WOMEN
Authors: Chang Hao-Ting , Liu Rui-Wen , Hsu Fang-Yuh , Hsu Ching-Han , Lin Yu-Ying 
Published: January 2023

AbstractThe Oak Ridge National Laboratory (ORNL) phantoms based on data of Caucasians have been widely used for fetal dosimetry. However, there are differences in body size during pregnancy among Taiwanese and Caucasians. In this study, the uterine dose conversion coefficients (DCCs) of Taiwanese pregnant women were evaluated to facilitate the use of it to estimate the possible uterine dose (usually regarded as fetal dose) of pregnant Taiwanese women during radiation practice or medical exposures. The uterine DCCs in this study were calculated based on the established Taiwanese pregnancy voxel phantoms, and were compared with the uterine DCCs of the International Commission on Radiological Protection. The applicability of evaluating uterine DCCs with different phantoms was also discussed. Results showed that if the ORNL phantoms are used to evaluate the uterine dose of Taiwanese pregnant women, the uterine dose may be underestimated. This study provides the uterine DCCs assessed with the Taiwanese pregnancy phantoms for future dose assessment of Taiwanese.
RESEARCH PROGRESS OF DEEP LEARNING IN LOW-DOSE CT IMAGE DENOISING
Authors: Zhang Fan , Liu Jingyu , Liu Ying , Zhang Xinhong 
Published: January 2023

AbstractLow-dose computed tomography (CT) will increase noise and artefacts while reducing the radiation dose, which will adversely affect the diagnosis of radiologists. Low-dose CT image denoising is a challenging task. There are essential differences between the traditional methods and the deep learning-based methods. This paper discusses the denoising approaches of low-dose CT image via deep learning. Deep learning-based methods have achieved relatively ideal denoising effects in both subjective visual quality and quantitative objective metrics. This paper focuses on three state-of-the-art deep learning-based image denoising methods, in addition, four traditional methods are used as the control group to compare the denoising effect. Comprehensive experiments show that the deep learning-based methods are superior to the traditional methods in low-dose CT images denoising.
Contribution of obstructive sleep apnea to disrupted sleep in a large clinical cohort of patients with suspected obstructive sleep apnea
Authors: Younes Magdy , Gerardy Bethany , Giannouli Eleni , Raneri Jill , Ayas Najib T , Skomro Robert , John Kimoff R , Series Frederic , Hanly Patrick J , Beaudin Andrew 
Published: January 2023

Abstract

Study Objectives
The response of sleep depth to CPAP in patients with OSA is unpredictable. The odds-ratio-product (ORP) is a continuous index of sleep depth and wake propensity that distinguishes different sleep depths within sleep stages, and different levels of vigilance during stage wake. When expressed as fractions of time spent in different ORP deciles, nine distinctive patterns are found. Only three of these are associated with OSA. We sought to determine whether sleep depth improves on CPAP exclusively in patients with these three ORP patterns.

Methods
ORP was measured during the diagnostic and therapeutic components of 576 split-night polysomnographic (PSG) studies. ORP architecture in the diagnostic section was classified into one of the nine possible ORP patterns and the changes in sleep architecture were determined on CPAP for each of these patterns. ORP architecture was similarly determined in the first half of 760 full-night diagnostic PSG studies and the changes in the second half were measured to control for differences in sleep architecture between the early and late portions of sleep time in the absence of CPAP.

Results
Frequency of the three ORP patterns increased progressively with the apnea-hypopnea index. Sleep depth improved significantly on CPAP only in the three ORP patterns associated with OSA. Changes in CPAP in the other six patterns, or in full diagnostic PSG studies, were insignificant or paradoxical.

Conclusions
ORP architecture types can identify patients in whom OSA adversely affects sleep and whose sleep is expected to improve on CPAP therapy.
Approach to acute kidney injury following paediatric kidney transplant
Authors: Atlas-Lazar Abigail , Levy-Erez Daniella 
Published: January 2023

Purpose of review
In a child with evidence of acute kidney injury (AKI) following renal transplantation, it is important to quickly and accurately diagnose the cause to enable timely initiation of therapeutic interventions. The following article will discuss the differential diagnosis of acute graft dysfunction in paediatric kidney transplant recipients. This review will systematically guide the clinician through the common and less common causes and provide updates on current treatments.

Recent findings
In patients with signs of graft dysfunction, rejection is an important cause to consider. Diagnosis of rejection relies on biopsy findings, an invasive and costly technique. Over the past 5 years, there has been a focus on noninvasive methods of diagnosing rejection, including serum and urinary biomarkers.

Summary
This review discusses the differential diagnosis of acute graft dysfunction following transplant, with a focus on acute rejection, urinary tract infections and common viral causes, prerenal and postrenal causes, nephrotoxic medications, specifically calcineurin inhibitor toxicity, thrombotic microangiopathy and recurrence of the underlying disease. Each condition is discussed in detail, with a focus on clinical clues to the cause, incidence in the paediatric population, workup and treatment.
A stochastic model of edge-localized modes in magnetically confined plasmas
Authors: Kim Eun-jin , Hollerbach Rainer 
Published: January 2023

Magnetically confined plasmas are far from equilibrium and pose considerable challenges in statistical analysis. We discuss a non-perturbative statistical method, namely a time-dependent probability density function (PDF) approach that is potentially useful for analysing time-varying, large, or non-Gaussian fluctuations and bursty events associated with instabilities in the low-to-high confinement transition and the H-mode. Specifically, we present a stochastic Langevin model of edge-localized modes (ELMs) by including stochastic noise terms in a previous ODE ELM model. We calculate exact time-dependent PDFs by numerically solving the Fokker–Planck equation and characterize time-varying statistical properties of ELMs for different energy fluxes and noise amplitudes. The stochastic noise is shown to introduce phase-mixing and plays a significant role in mitigating extreme bursts of large ELMs. Furthermore, based on time-dependent PDFs, we provide a path-dependent information geometric theory of the ELM dynamics and demonstrate its utility in capturing self-regulatory relaxation oscillations, bursts and a sudden change in the system.This article is part of a discussion meeting issue ‘H-mode transition and pedestal studies in fusion plasmas’.
H-mode transition and pedestal studies
Authors: Andrew Yasmin , Kim Eun-jin 
Published: January 2023

The high confinement mode (H-mode) is the widely adopted standard operation scenario for the path to fusion in toroidal confinement devices. Since its discovery in 1982, the H-mode and access to the H-mode (the low to high and high to low transitions) remain two of the most actively researched areas in magnetically confined fusion programmes across the world. Significant progress has been made in the understanding of the intricate H-mode phase dynamics in recent years, from improvement in experimental diagnostic capability, theoretical development and modelling. The ‘H-mode transition and pedestal studies’ Special Issue provides a timely overview of recent progress in the study of H-modes covering experimental studies, further theoretical inquiry and computational modelling.This article is part of a discussion meeting issue ‘H-mode transition and pedestal studies in fusion plasmas’.
Red matte and glossy blue: how color and reflectance drive consumer indulgence
Authors: Khalil Shadab , Chatterjee Pubali , Cheng Julian Ming-Sung 
Published: January 2023

PurposeThis study aims to investigate the effect of color temperature on consumption. Color is one of the most powerful elements of sensory marketing. However, how warm and cool colors drive consumer indulgence and interact with other visual cues is minimally understood.Design/methodology/approachThis research conducts six experiments to investigate the effect of eight warm and cool colors and the effect of warm/cool color’s interaction with reflectance on indulgent consumption/use in various retail environments.FindingsStudies 1a and 1b support the contrasting effects of warm vs cool colors on consumers’ indulgent consumption. Studies 2a and 2b establish the serial mediating role of arousal and self-reward focus in the color-indulgence relationship. Study 3a demonstrates the interactive effect of warm (vs cool) colors and glossy (vs matte) reflectance on consumer indulgence, and Study 3b confirms how glossy (vs matte) reflectance moderates the serial mediating effect of arousal and self-reward focus in the color-indulgence relationship.Research limitations/implicationsThis research contributes to the growing stream of research on the visual aspect of sensory marketing, especially color, and advances the theoretical knowledge of how color could be used effectively to influence consumer indulgence.Practical implicationsThis research provides actionable managerial implications on the effective use of warm and cool colors and glossy and matte reflectance to influence consumer indulgence.Originality/valueThis research advances the theoretical and empirical knowledge of color’s interaction with other visual sensory cues and the underlying psychological processes shaping consumer indulgence.
Advances in event management using new technologies and mobile applications
Authors: García Revilla Raquel , Martinez Moure Olga , Einsle Carmen Sarah 
Published: January 2023

PurposeIn this work, the authors present a review of mobile applications for event management available for smartphones with the iOS operating system. The objective of the work is to carry out an analysis of these applications, offering an educational point of view and filling a gap in the doctrine, as the authors are dealing with an academically still new subject.Design/methodology/approachFirst, the authors conducted a literature review regarding the impact of technology on event organizations. Second, the authors analysed mobile applications for event management, the results of which are presented in this paper. Particularly, its main characteristics, strengths and weaknesses are analysed. Finally, the authors present the design of an activity with one of the beforehand analysed applications, in order to see its contribution to event management education.FindingsIt has been possible to improve learning and acquire specific skills related to the subject of study. Specified event management applications offer a wide range of advantages to facilitate the planning and management of events.Practical implicationsThe study provides practical implications for managers in the hospitality industry.Originality/valueThis study provides a deeper insight into the functionalities and usefulness of event management mobile applications.