bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunometabolic cues recompose and reprogram the microenvironment around biomaterials
Authors: Maduka Chima V. , Schmitter-Sánchez Axel D. , Makela Ashley V. , Ural Evran , Stivers Katlin B. , Pope Hunter , Kuhnert Maxwell M. , Habeeb Oluwatosin M. , Tundo Anthony , Alhaj Mohammed , Kiselev Artem , Chen Shoue , Olive Andrew J. , Hankenson Kurt D. , Narayan Ramani , Park Sangbum , Elisseeff Jennifer H. , Contag Christopher H. 
Published: July 2023

AbstractCirculating monocytes infiltrate and coordinate immune responses in various inflamed tissues, such as those surrounding implanted biomaterials, affecting therapeutic, diagnostic, tissue engineering and regenerative applications. Here, we show that immunometabolic cues in the biomaterial microenvironment govern CCR2- and CX3CR1-dependent trafficking of immune cells, including neutrophils and monocytes; ultimately, this affects the composition and activation states of macrophage and dendritic cell populations. Furthermore, immunometabolic cues around implants orchestrate the relative composition of proinflammatory, transitory and anti-inflammatory CCR2+, CX3CR1+and CCR2+CX3CR1+immune cell populations. Consequently, modifying immunometabolism by glycolytic inhibition drives a pro-regenerative microenvironment in part by myeloid cells around amorphous polylactide implants. In addition to, Arginase 1-expressing myeloid cells, T helper 2 cells and γδ+T-cells producing IL-4 significantly contribute to shaping the metabolically reprogramed, pro-regenerative microenvironment around crystalline polylactide biomaterials. Taken together, we find that local metabolic states regulate inflammatory processes in the biomaterial microenvironment, with implications for translational medicine.
Analysis of public health-care facilities in rural India
Authors: Sahoo Pragyan Monalisa , Rout Himanshu Sekhar 
Published: July 2023

PurposeThis paper aims to analyze the status of infrastructure, workforce and basic amenities at public health-care facilities in rural India and draw a comparison with its urban counterparts.Design/methodology/approachRural Health Statistics data and National Sample Survey Office Report for the period 2019–10 were used to analyze lower-level public health facilities, namely, subcenters, primary health centers and community health centers (CHCs). Selected tracer indicators under World Health Organization’s (WHO) Service Availability and Readiness Assessment (SARA) mechanism such as health center density, core health workforce density and basic amenities were used to carry out the analysis. The extent of facility coverage was measured using the National Rural Health Mission (NRHM) guidelines and the proportion of facilities satisfying the Indian Public Health Standards (IPHS) was measured to assess the service provision quality in rural public health-care facilities.FindingsResults indicated that the density of public health centers is higher in rural areas than in urban areas. Almost all public health-care facilities lack basic amenities in rural areas. Working positions for health specialists in CHCs barely meet the total requirement. Almost all of the public health facilities functioning in rural areas do not meet the IPHS norms.Originality/valueTo the best of the authors’ knowledge, the present paper is the first initiative to assess the status of rural public health-care facilities on the national level using WHO’s SARA indicators as well as NRHM and IPHS guidelines. The study is significant in terms of policy input for achieving universal health coverage in India.
The illusion of reality in the gaming world: implications for libraries
Authors: Ajani Yusuf Ayodeji , Ahmed Abdulganiy Okanla , Muhammed Rihanat Bukola 
Published: July 2023

Purpose
The main purpose of this paper is to explore implications of the illusion of reality in the gaming world for libraries, aiming to uncover the challenges and opportunities they face in adapting their services to the gaming context.

Design/methodology/approach
Through a comprehensive exploration of the topic, various sources, such as Scopus, Google Scholar and ResearchGate were used. This study draws upon existing literature to analyze the impact of the illusion of reality in gaming on libraries and their offerings.

Findings
The findings emphasize the crucial role of libraries in comprehending the illusion of reality in gaming to remain relevant and effectively meet the evolving needs of patrons. It also emphasize the impact of the illusion of reality on user engagement, information-seeking behaviors, digital literacy challenges and the evolving gaming landscape. The findings highlight opportunities for libraries to leverage the illusion of reality, thereby enhancing user experiences, fostering community engagement, promoting information literacy and creating immersive learning environments.

Originality/value
This paper contributes a unique investigation into the impact of the illusion of reality in gaming on libraries, underscoring its significance. It offers practical recommendations to enhance library services, user experiences and community engagement within the gaming domain. The study provides valuable insights for library professionals, researchers and policymakers seeking to understand and adapt to the changing dynamics of the gaming world.
Resilience of small retailers in facing the Covid-19 pandemic – a qualitative study
Authors: Samanta Tamal , Aithal Rajesh 
Published: July 2023

Purpose
This study aims to understand the impact of the Covid-19 pandemic on small retailers, and their response to it, using the crisis management model. The research documents the impact and responses and attempts to identify the factors contributing to and hindering retailers’ attempts to achieve resilience.

Design/methodology/approach
Semi-structured interviews were used to collect qualitative data from small retailers. The interview transcripts were analysed using MAXQDA 2020 Analytics Pro data analysis software. The heterogeneity in responses to the challenges posed by the pandemic is explained using self-determination theory and diffusion of innovation theory.

Findings
One of the most significant impacts of the crisis was the disruption in the regular supply chain network on which the studied retailers relied for their traditional buying. The retailers increased customer services such as free home delivery and enhanced the use of technology in their shops. However, and worryingly, although the retailers faced two waves of the pandemic, the urge to plan and prepare was missing. The overall crisis can, therefore, be seen as an opportunity for small retailers to improve their responses when facing similar situations.

Social implications
Small retailers are part of the social fabric in many emerging economies and function as a source of employment. They have been facing challenges from organised retail and e-commerce. The Covid-19 crisis pushed them to respond, and the authors hope that they will take some cues from this disruption and become more efficient and competitive in the future.

Originality/value
To the best of the authors’ knowledge, this is among the first studies to map the impact of the crisis on small retailers and their response to it, drawing implications for retailers and companies and analysing the efforts made by small retailers to achieve resilience.
A story-net approach to qualitative research: having tea with stories!
Authors: Price Shelley Teresa , Hartt Christopher Michael 
Published: July 2023

PurposeThe purpose of this paper is to share the story-net approach and to situate it as one that benefits from blending story as Indigenous methodology with non-corporeal actant theory (NCAT). The authors hope it will serve useful in building storytelling communities where Indigenous and non-Indigenous scholars are working to heal together from colonial trauma, reveal the inner workings of historical and ongoing colonial projects, dismantle the agency of colonial projects, and welcome heartful dialogue into the centre of MOS discourse.Design/methodology/approachThe authors employ a storytelling approach which includes mapping the story-net territory and identifying the plot points along the journey. The authors use the story-net approach to story the approach.FindingsThis approach served helpful when engaging within story archives and with storytelling collectives comprised of both Indigenous and non-Indigenous persons, peoples and knowledges. The authors found four key premises, which help to narrate the ontology, epistemology, methodology and axiology of the story-net approach and six plot points, which help in mapping the lessons learned from engaging with stories, storytellers, story listeners and the socio-discursive contexts surrounding story-net work.Originality/valueThe authors story an approach that can be useful to support emerging Indigenous scholars while engaging with their non-Indigenous colleagues to do story-net work. This approach may be useful to navigate the tensions to create safer, more humane, inclusive, relational, strengths-based and trauma-informed spaces for engaging with Indigenous stories, storytellers, story listeners and discourses, as well as, to plot the points of contention so as to set the stage for deepening respectful research relations.
Hyperhidrosis: A targeted literature review of the disease burden
Authors: Oshima Yuichiro , Fujimoto Tomoko , Nomoto Mariko , Fukui Junko , Ikoma Akihiko 
Published: July 2023

AbstractHyperhidrosis is a chronic skin condition characterized by excessive sweating. It poses a burden on affected people, reducing their quality of life and productivity. We undertook a targeted literature review (TLR) to gather current evidence on the epidemiology as well as the human and economic burden posed on patients with hyperhidrosis. Searches were performed in Medline database (access via OVID interface) and ICHUSHI database. Articles published between January 2000 and September 2020 that analyzed at least 50 patients were included. Sixty‐four publications were identified and 38 publications covering a unique domain were selected to inform this TLR. The incidence of hyperhidrosis ranged from 0.13% in the UK to 0.28% in the USA, with a higher rate in females. The prevalence of hyperhidrosis varied from 2.8%–4.8% in the US general population to 18.40% in Chinese inpatients, while the prevalence of axillary hyperhidrosis varied from 1.4% in the US general population to 5.75% in Japanese employees/students. Due to excessive sweating, hyperhidrosis was reported to be a moderate‐to‐extreme limitation at work for the US patients, with 33.5% feeling unhappy. Patients' satisfaction was high post‐treatment. Considerable costs were related to the treatment with botulinum toxin and surgery. Hospital stays for surgery lasted from 10 h to 3 days. The percentage of patients who sought a medical consultation varied from 6.3% for Japanese patients with primary focal hyperhidrosis to 51% for the US general population with any type of hyperhidrosis. There is limited evidence of the hyperhidrosis burden, particularly among Japanese patients; however, the burden was high and limited patients' daily functioning. Future actions should include implementation of educational programs to raise awareness of the condition, conduct of larger studies, and generation of more evidence. Understanding the nature of hyperhidrosis and the burden it poses is of utmost importance.
Association between pregnancy affected by vaginal bleeding and women's mortality: A cohort study
Authors: Dudukina Elena , Horváth‐Puhó Erzsébet , Sørensen Henrik Toft , Ehrenstein Vera 
Published: July 2023

AbstractObjectiveTo investigate the association between vaginal bleeding (VB) in pregnancy and women's mortality, using VB‐unaffected pregnancies, terminations and miscarriages as comparators.DesignObservational cohort study.SettingNationwide registries of Denmark linked at an individual level.Population or Sample1 354 181 women and their 3 162 317 pregnancies (1979–2017), including 70 835 VB‐affected pregnancies and comparators: 2 236 359 VB‐unaffected pregnancies ending in childbirth; 589 697 terminations; and 265 426 miscarriages.MethodsWe followed pregnancies until the earliest date of woman's death, emigration or end of data.Main outcome measuresAll‐cause and cause‐specific mortality rates per 10 000 person‐years (PY) and hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted using Cox proportional hazards regression for age, calendar year, pre‐existing chronic conditions and socio‐economic factors.ResultsThere were 2320 deaths from any cause among women following VB‐affected pregnancy (mortality rate 15.2, 95% CI 14.6–15.9 per 10 000 PY); 55 030 deaths following VB‐unaffected pregnancy (mortality rate 12.7, 95% CI 12.6–12.8); 27 500 deaths following a termination (mortality rate 21.9, 95% CI 21.6–22.1), and 10 865 deaths following a miscarriage (mortality rate 19.2, 95% CI 18.8–19.6). For comparison of VB‐affected versus VB‐unaffected pregnancies, associations with all‐cause (HR 1.14, 95% CI 1.09–1.19), natural causes (HR 1.15, 95% CI 1.09–1.22) and non‐natural causes (HR 1.27, 95% CI 1.08–1.48) mortality were attenuated in a sensitivity analysis of pregnancies recorded in 1994–2017 (HR 1.00, 95% CI 0.90–1.12, HR 0.98, 95% CI 0.85–1.14 and HR 1.04, 95% CI 0.72–1.51, respectively). Contrasts with remaining comparators did not suggest increased risks of all‐cause, natural or non‐natural mortality causes.ConclusionWe found no evidence of an increased risk of women's mortality following VB‐affected versus VB‐unaffected pregnancy, termination or miscarriage.
Financial regulatory conundrums in the North Atlantic
Authors: POSNER ELLIOT , QUAGLIA LUCIA 
Published: July 2023

AbstractThis article explains a dominant, curious and important pattern that emerges from our original data on 11 areas of financial regulation in the United States and the European Union from the Great Financial Crisis to 2020: sustained regulatory stringency in both jurisdictions. Our novel explanation, rooted in theories about international economic interdependence, temporal process and market power, emphasizes cross‐border interactions that arose from a build‐up of ‘border‐policing’ capacities. Our medium‐n study, which combines congruence analysis and process tracing, reveals a causal mechanism – ‘joint reinforcement’ – whereby the potential penalties imposed by one of the two jurisdictions prevent or temper the other from watering down‐regulation. The study pushes the boundaries of qualitative research, advances theory and speaks to debates about global public goods.
Exploring the roles of natural resources on sustainability blueprint in G7 countries amidst green energy, technological innovation, and carbon‐tax intervention
Authors: Dong Xinhui , Ibrahim Ridwan Lanre , Ozturk Ilhan , Al‐Faryan Mamdouh Abdulaziz Saleh 
Published: July 2023

AbstractToday's global economy faces the most devastating challenges of global warming occasioned by overdependence on natural resources. Besides, the dilemma of choosing between economic benefits and environmental costs emanating from natural resources heightens the empirical relevance of green energy in recent times. To solve this developmental puzzle, the current study presents extends the knowledge frontier by evaluating the impacts of natural resource dependence, green energy (captured by biofuels and renewable energy), carbon tax, and technological innovation on environmental sustainability in G7 economies. The empirical model endogenizes environmental policy stringency and financial development from 1996 to 2019. The empirical verification anchors on second‐generation estimators entailing Cross‐Sectional Autoregressive Distributed Lag (CS‐ARDL), Common Correlated Effects Mean Group (CCEMG), augmented mean group (AMG), and novel Method of Moment Quantile Regression (MMQR). The fallouts from the analyses uncover that natural resource dependence militates against the attainment of the sustainability blueprint by escalating the surge in CO2 emissions in G7 countries. Similarly, the feedbacks from financial development support the surge in emissions. On the flip side, green energy, technological innovation, carbon tax, and environmental policy appear as effective tools for mitigating the surge. The Fully Modified Ordinary Least Square (FMOLS) estimator for the country‐specific analysis corroborates the panel findings. Additionally, two channels of causalities, including unidirectional and bidirectional nexuses, are apparent from the estimated model. Policy measures are suggested based on empirical findings.
Bone mineral density and its influential factors in Chinese patients with newly diagnosed Crohn's disease
Authors: Zhao Yuan , Li Xiao Xuan , Li Fan , Yao Ling Ya , Liu Jing , Cao Qian 
Published: July 2023

ObjectivesBone loss is a common morbidity in patients with inflammatory bowel disease (IBD). Bone mineral density (BMD) measurement is recommended for IBD patients at a high risk of osteoporosis. However, there is a lack of evidence in the need of BMD measurement in patients who are young at the first disease onset. In this study we aimed to investigate the prevalence of low BMD in patients with newly diagnosed Crohn's disease (CD) at 20–50 years of age and the potential risk factors.MethodsA single‐center, retrospective cross‐sectional study was conducted. Medical records of the patients were reviewed and their demographics, clinical characteristics and laboratory test results were collected. Dual energy X‐ray absorptiometry (DEXA) scan was performed for BMD measurements; low BMD was defined as Z‐score or T‐score <−1.0 standard deviation (SD). Univariate and multivariate logistic regression analyses were used to determine the risk factors for low BMD.ResultsA total of 221 patients with CD were included; osteopenia and osteoporosis were identified in 23.1% and 8.6%, and 39.4% and 7.2% of the patients using Z‐score and T‐score, respectively. Female gender and a higher BMI at diagnosis were protective factors for low BMD.ConclusionsLow BMD is common in patients with newly diagnosed CD aged 20–50 years. Female gender and a higher BMI at diagnosis might protect CD patients from bone loss. Therefore, BMD measurement and early intervention with calcium and vitamin D are recommended for these patients.
Beta‐cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced?
Authors: Sayyed Kassem Laure , Rajpal Aman , Barreiro Margarita Victoria , Ismail‐Beigi Faramarz 
Published: July 2023

AbstractType 2 diabetes (T2DM) is a complex metabolic disorder manifested by hyperglycemia, insulin resistance, and deteriorating beta‐cell function. A way to prevent progression of the disease might be to enhance beta‐cell function and insulin secretion. However, most previous studies examined beta‐cell function while patients were using glycemia‐lowering agents without an adequate period off medications (washout). In the present review we focus on studies with a washout period. We performed a literature search (2010 to June 2021) using beta‐cell function and enhancement. The evidence shows that beta‐cell function can be enhanced. Bariatric surgery and very low calorie diets show improvement in beta‐cell function in many individuals. In addition, use of glucagon‐like peptide‐1 receptor agonists for prolonged periods (3 years or more) can also lead to improvement of beta‐cell function. Further research is needed to understand the mechanisms leading to improved beta‐cell function and identify agents that could enhance beta‐cell function in patients with T2DM.
Antibody response to inactivated COVID‐19 vaccine in patients with type 2 diabetes mellitus after the booster immunization
Authors: Li Haolong , Wang Yao , Li Xiaomeng , Wang Siyu , Feng Xinxin , Xiao Xinhua , Li Yongzhe 
Published: July 2023

AbstractBackgroundThe immunogenicity of booster inactivated COVID‐19 vaccines in patients with type 2 diabetes mellitus (T2DM) has remained unclear. Our study aims to investigate the antibody response to inactivated COVID‐19 vaccine following booster vaccination in patients with T2DM.MethodsA total of 201 patients with T2DM and 102 healthy controls (HCs) were enrolled. The levels of anti‐SARS‐CoV‐2 total antibodies, anti‐receptor‐binding domain (RBD)‐specific IgG, neutralizing antibody (NAb) toward SARS‐CoV‐2 wild type (WT), and NAb toward SARS‐CoV‐2 Omicron BA.4/5 subvariant were measured to evaluate the vaccine‐induced immunological responses.ResultsThe titers of anti‐RBD‐specific IgG (p = 0.018) and inhibition rates of NAb toward WT (p = 0.007) were significantly decreased in patients with T2DM compared to HCs after booster vaccination for more than 6 months. Both HCs and patients with T2DM showed poor resistance against BA.4/5 due to the detected inhibition rates being lower than the positive threshold. The levels of anti‐RBD‐specific IgG were positively associated with the proportions of CD3+CD4−CD8− T cells (p = 0.045), and patients with T2DM who had anti‐RBD‐specific IgG positivity showed higher proportions of CD3+CD4−CD8− T cells compared to those negative (p = 0.005).ConclusionsPatients with T2DM showed impaired antibody responses after booster vaccination for more than 6 months. Decreased anti‐BA.4/5 responses give rise to the possibility of breakthrough infections for both patients with T2DM and HCs.
A case of Behçet syndrome presenting with acute coronary syndrome
Authors: Akkuzu Gamze , Erdoğan Aslan , Moustafa Chanife , Deniz Rabia , Özgür Duygu Sevinç , Karaalioğlu Bilgin , Yıldırım Fatih , Bes Cemal 
Published: July 2023

AbstractCardiac involvement (CI) is rare in Behçet syndrome (BS), but the important point is that CI may be the first manifestation of the disease. The presence of CI worsens the prognosis of BS, so early diagnosis and early initiation of immunosuppressive treatment (IST) are vital. Coronary aneurysm may develop spontaneously in these patients, or any vascular intervention may cause aneurysm with a pathergy‐like reaction. The risk of restenosis is high after percutaneous coronary intervention or coronary artery bypass surgery applied without IST. Therefore, it should be kept in mind that IST constitutes the main step of treatment. Herein, we present a young male diagnosed with BS after acute coronary syndrome caused by coronary artery aneurysms and thrombosis.
A case of certolizumab‐induced purpura annularis telangiectodes of Majocchi and literature review
Authors: Karstarlı Bakay Ozge S. , Bakay Umut 
Published: July 2023

AbstractTumor necrosis factor alpha (TNFα) inhibitors are now widely used to treat immune‐mediated inflammatory diseases. Although they have a good safety profile, they are also associated with adverse cutaneous events. Pigmented purpuric dermatoses (PPD) include a variety of skin diseases characterized by multiple petechial hemorrhages due to capillaritis. Five major clinical types of PPD have been described and purpura annularis telangiectodes of Majocchi (PATM) is a rare subtype of PPD. The cause of PPD is unknown, but drugs are implicated in a minority of cases. There are very few cases in the literature triggered by TNFα inhibitors. We present a case of PATM induced by certolizumab pegol and perform a review including 4 articles in the literature reporting 5 PPD cases induced by TNFα inhibitors. When purpuric eruptions develop in patients treated with TNFα inhibitors, PPD and vasculitis should be differentiated. Thus, patients are not exposed to unnecessary evaluations and treatments.