bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taking a partnership approach to embed physical activity in local policy and practice: a Bradford District case study
Authors: Hall Jennifer , Lever Elliot , Dawkins Nathan , Young Emma , Crowther Jamie , Williams Rachel , Pickavance John , Barber Sally , Daly-Smith Andy , Chalkley Anna ,   On behalf of the wider JU:MP team
Published: January 2025

Abstract
Background
Supportive policy is an important component of a whole-systems approach to increasing physical activity and reducing inequalities. There is a growing body of literature surrounding the design and effectiveness of national policy approaches to physical activity, but evidence related to local-level approaches is lacking. The aim of this study was to examine ‘what works’, and identify factors underpinning change, focused on work to embed physical activity in local policy and practice in Bradford, UK.

Methods
A mixed-methods case study approach involved collecting data from cross-sectoral stakeholders directly or indirectly engaged in the physical activity agenda in Bradford over a period of three years (2021–2024). Data collection included focus groups, semi-structured interviews, researcher observations of key workshops and meetings, and surveys at two time-points (December 2021 and January 2024). Qualitative data were analysed using reflexive thematic analysis. Quantitative data were analysed using descriptive and inferential statistics.

Results
Four themes were identified which embody conditions that appear to be critical for working towards physical activity being embedded in local policy & practice within the Bradford District. These included: collaboration and sector integration, co-productive working, governance and leadership, and cultivating a learning culture. The process of co-producing a district-wide strategy for physical activity was key to facilitating shared ownership of the physical activity agenda across different levels of the system, and for supporting and maintaining cross-sectoral collaboration. On average, survey respondents connected with four more local organisations in relation to the physical activity agenda in January 2024 than in December 2021.

Conclusion
Taking a partnership approach, and fostering a culture of evidence-informed decision making, is key to embedding physical activity into policy and practice at a local level. Investing time to understand the aims and values of each partner, and potential synergies and tensions between them, can support the development of a positive and productive collaboration and, subsequently, more effective whole-system delivery and population-level increases in physical activity.
Clinical management of female patients with Fabry disease based on expert consensus
Authors: Brand Eva , Linhart Aleš , Deegan Patrick , Jurcut Ruxandra , Pisani Antonio , Torra Roser , Feldt-Rasmussen Ulla 
Published: January 2025

AbstractFabry disease is an X-linked lysosomal storage disorder that causes accumulation of glycosphingolipids in body tissues and fluids, leading to progressive organ damage and life-threatening complications. It can affect both males and females and can be classified into classic or later-onset phenotypes. The disease severity in females ranges from asymptomatic to the more severe, classic phenotype. Most females are hemizygous and the X-linked inheritance is associated with variable X-activation pattern and residual enzymatic activity. The heterogeneity of clinical presentation in females requires different approaches to diagnosis and management than males. A European group of 7 physicians, experienced in the management of Fabry disease, convened to discuss patient perspectives and published guidelines. The experts discussed the need to focus on psychological treatment in relation to individual coping styles when monitoring targets, and the lack of data supporting the use of plasma globotriaosylsphingosine over enzyme activity in the diagnosis of these patients. It was suggested that the high phenotypic variability in female patients may be related to the dynamic nature of the X-chromosome inactivation process and further understanding of this process could help predict the progression of Fabry disease in females and facilitate timely intervention. Due to the range of disease severity they exhibit, female patients with Fabry disease may require a more individualized treatment approach than males. Despite current recommendations, the experts agreed that early disease-specific treatment initiation in high-risk females could improve clinical outcome.
Periostin-mediated NOTCH1 activation between tumor cells and HSCs crosstalk promotes liver metastasis of small cell lung cancer
Authors: Lou Linlin , Peng Keren , Ouyang Shumin , Ding Wen , Mo Jianshan , Yan Jiayu , Gong Xiaoxiao , Liu Guopin , Lu Jinjian , Yue Peibin , Zhang Kai , Zhang Jian , Wang Yan-dong , Zhang Xiao-lei 
Published: January 2025

Abstract
Background
Metastasis is the primary cause of mortality in small cell lung cancer (SCLC), with the liver being a predominant site for distal metastasis. Despite this clinical significance, mechanisms underlying the interaction between SCLC and liver microenvironment, fostering metastasis, remain unclear.

Methods
SCLC patient tissue array, bioinformatics analysis were performed to demonstrate the role of periostin (POSTN) in SCLC progression, metastasis, and prognosis. Cell migration, invasion and sphere formation assay were performed to determine the oncogenic role of POSTN. RNA sequencing analysis was utilized to identify the key signaling pathway regulated by POSTN. Immunoprecipitation, immunofluorescence and co-culture system were used to clarify the mechanism of POSTN-NOTCH1 axis in tumor cells-hepatic stellate cells (HSCs) crosstalk. Subcutaneous xenograft model and liver metastasis model were established to examine the anti-tumor growth and metastases effect of targeting POSTN-NOTCH1 signaling axis.

Results
Elevated expression of POSTN in SCLC is correlated with accelerated tumor progression and metastasis. Conditioned medium rich in POSTN derived from SCLC tumors demonstrates the ability to activate HSCs in the liver microenvironment. Mechanistically, POSTN emerges as a binding partner for the membrane receptor NOTCH1 and transducing the extracellular signals to intracellular fibroblasts. Furthermore, targeting the POSTN-NOTCH1 signaling axis proves effective in suppressing SCLC tumor growth and inhibiting liver metastasis. This study elucidates that the SCLC-derived secreted protein POSTN interacts with NOTCH1 on HSCs to promote the activation of HSCs, thereby providing a favorable microenvironment for liver metastasis.

Conclusion
These findings uncover the intricate communications between primary SCLC cells and HSCs in the tumor microenvironment mediated by the secreted protein POSTN in the context of liver metastasis. Consequently, targeting the POSTN-NOTCH1 signaling axis emerges as a promising therapeutic strategy for metastatic SCLC.
Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study
Authors: Phoophiboon Vorakamol , Rodrigues Antenor , Vieira Fernando , Ko Matthew , Madotto Fabiana , Schreiber Annia , Sun Nannan , Sousa Mayson L. A. , Docci Mattia , Brault Clement , Menga Luca S. , Telias Irene , Piraino Thomas , Goligher Ewan C. , Brochard Laurent 
Published: January 2025

Abstract

Background
Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional ventilation distribution and could bring additional information.
Research question.
Whether the display of regional ventilation distribution during a Spontaneous Breathing Trial (SBT) could help at predicting early and successful liberation from MV.

Study design and methods
Patients were monitored with EIT during the SBT. The tidal image was divided into ventral and dorsal regions and displayed simultaneously. We explored the ventral-to-dorsal ventilation difference in percentage, and its association with clinical outcomes. Liberation success was defined pragmatically as passing SBT followed by extubation within 24 h without reintubation for 7 days. Failure included use of rescue therapy, reintubation within 7 days, tracheostomy, and not being extubated within 24 h after succesful SBT. A training cohort was used for discovery, followed by a validation cohort.

Results
Among a total of 98 patients analyzed, 85 passed SBT (87%), but rapid liberation success occurred only in 40; 13.5% of extubated patients required reintubation. From the first minutes to the entire SBT duration, the absolute ventral-to-dorsal difference was consistently smaller in liberation success compared to all subgroups of failure (p < 0.0001). An absolute difference at 5 min of SBT > 20% was associated with failure of liberation, with sensitivity and specificity of 71% and 78% and positive predictive value 81% in a validation cohort.

Conclusion
During SBT, a large ventral-to-dorsal difference in ventilation indicated by EIT may help to rapidly identify patients at risk of liberation failure.
A newly developed high-performance thin layer chromatographic method for determination of remdesivir, favipiravir and dexamethasone, in spiked human plasma: comparison with the published methods
Authors: Abdelfatah Rehab M. , Abdelmomen Esraa H. , Abdelaleem Eglal A. , Abdelmoety Refaat H. , Emam Aml A. 
Published: January 2025

AbstractCo-administration of COVID-19 RNA polymerase inhibitors, remdesivir and favipiravir, has synergistic benefits. Together they reduce viral load and inflammation more effectively than either drug used alone. Corticosteroids like dexamethasone are used alongside antivirals in multidrug combination regimens. A new HPTLC method was utilized to isolate and quantitatively determine the three medicines of the COVID-19 therapeutic protocol, remdesivir, favipiravir and dexamethasone, using the anticoagulant apixaban as an internal standard in human plasma. The mobile phase system used a solvent mixture of ethyl acetate, hexane, and acetic acid (9:1:0.3, by volume). At 254 nm, well-resolved spots with Rf values of 0.3 for remdesivir, 0.64 for dexamethasone, and 0.77 for favipiravir have been observed. To ensure compliance with FDA regulations, a validation study was conducted. Quantitation limits as low as 0.1 µg/band have been achieved with remdesivir and dexamethasone, and 0.2 µg/band with favipiravir, demonstrating excellent sensitivities. From 97.07% to 102.77%, the drugs were recovered from human plasma that had been artificially spiked. The whiteness of the method has been assessed using RGB 12 algorithm and a percentage of whiteness of 95.6% has been obtained.
The sow vaginal and gut microbiota associated with longevity and reproductive performance
Authors: Liu Ziyu , Tsai Tsungcheng , Zuo Bin , Howe Samantha , Farrar Jason E. , Randolph Christopher E. , Maxwell Charles V. , Zhao Jiangchao 
Published: January 2025

Abstract
Background
Sow longevity and reproductivity are essential in the modern swine industry. Although many studies have focused on the genetic and genomic factors for selection, little is known about the associations between the microbiome and sows with longevity in reproduction.

Results
In this study, we collected and sequenced rectal and vaginal swabs from 48 sows, nine of which completed up to four parities (U4P group), exhibiting reproductive longevity. We first identified predictors of sow longevity in the rectum (e.g., Akkermansia) and vagina (e.g., Lactobacillus) of the U4P group using RandomForest in the early breeding stage of the first parity. Interestingly, these bacteria in the U4P group showed decreased predicted KEGG gene abundance involved in the biosynthesis of amino acids. Then, we tracked the longitudinal changes of the microbiome over four parities in the U4P sows. LEfSe analysis revealed parity-associated bacteria that existed in both the rectum and vagina (e.g., Streptococcus in Parity 1, Lactobacillus in Parity 2, Veillonella in Parity 4). We also identified patterns of bacterial change between the early breeding stage (d 0) and d 110, such as Streptococcus, which was decreased in all four parties. Furthermore, sows in the U4P group with longevity potential also showed better reproductive performance. Finally, we discovered bacterial predictors (e.g., Prevotellaceae NK3B31 group) for the total number of piglets born throughout the four parities in both the rectum and vagina.

Conclusions
This study highlights how the rectal and vaginal microbiome in sows with longevity in reproduction changes within four parities. The identification of parity-associated, pregnancy-related, and reproductive performance-correlated bacteria provides the foundation for targeted microbiome modulation to improve animal production.
Investigation of the relationship between number of tweets and USDTRY exchange rate with wavelet coherence and transfer entropy analysis
Authors: Karatas Cengiz , Tuysuz Sukriye , Kucuklerli Kazim Berk , Ulusoy Veysel 
Published: January 2025

AbstractPredicting the currency exchange rate is crucial for financial agents, risk managers, and policymakers. Traditional approaches use publicly announced news on macroeconomic and financial variables as predictors of currency exchange. However, the rise of social media may have changed the source of information. For instance, tweets can help investors make informed decisions about the foreign exchange (FX) market by reflecting market sentiment and opinion. From another aspect, changes in currency exchange may incite agents to post tweets. Are tweets good predictors of currency exchange? Is the relationship between tweets and currency exchange bidirectional? We investigate the comovement/causality between the number of #dolar (“enflasyon” resp.) tweets and USDTRY currency exchange using wavelet coherence and transfer entropy (TE) to answer these questions. Wavelet coherence allows us to determine the relationship between the number of tweets and the USDTRY rate by considering the time–frequency domain. TE enables us to quantify the net information flow between the number of tweets and USDTRY. Data from October 2020 to March 2022 were used. The obtained results remain robust regardless of the frequency of retained data (daily or hourly) and the methods used (wavelet or TE). Based on our results, USDTRY is correlated with the number of #dolar tweets (#inflation) mainly in the short run and a few times in the medium run. These relationships change through time and frequency (wavelet analysis results). However, the results from TE indicate a bidirectional relationship between the #dolar (#inflation) tweets number and the USDTRY exchange rate. The influence of the exchange rate on the number of tweets is highly pronounced. Financial agents, risk managers, policymakers, and investors should then pay moderate attention to the number of #dolar (#inflation) tweets in trading/forecasting the USD–TRY exchange rate.
ICOs conceptual unveiled: scholarly review of an entrepreneurial finance innovation
Authors: Joshipura Mayank , El Khoury Rim , Alshater Muneer M. 
Published: January 2025

AbstractThis review synthesizes 48 academic studies on Initial Coin Offerings (ICOs) from 2018 to 2023, employing bibliometric and content analyses to illuminate their complexities and innovation in entrepreneurial finance. It identifies four key themes: (1) regulatory intricacies, market transformation, and strategic implications for emerging ventures; (2) the opportunities and challenges presented, and key factors influencing the success of ICOs; (3) ICOs and entrepreneurial finance; and finally, (4) review of reviews. By examining the intersection of legal frameworks, disruptive potential, and stakeholder challenges, this interdisciplinary perspective captures the essence of ICOs and charts a course for future inquiry. It serves as a pivotal reference for researchers, practitioners, and regulators to understand the multifaceted ICO landscape and its implications for the future of finance.
Brentuximab Vedotin Combination for Relapsed Diffuse Large B-Cell Lymphoma
Authors: Bartlett Nancy L. , Hahn Uwe , Kim Won-Seog , Fleury Isabelle , Laribi Kamel , Bergua Juan-Miguel , Bouabdallah Krimo , Forward Nicholas , Bijou Fontanet , MacDonald David , Portell Craig A. , Ghesquieres Herve , Nowakowski Grzegorz , Yasenchak Christopher A. , Patterson Monica , Ho Linda , Rustia Evelyn , Fanale Michelle , Jie Fei , Kim Jeong-A 
Published: January 2025

PURPOSE
In patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), brentuximab vedotin (BV) as monotherapy or combined with either lenalidomide (Len) or rituximab (R) has demonstrated efficacy with acceptable safety. We evaluated the efficacy and safety of BV + Len + R versus placebo + Len + R in patients with R/R DLBCL.

METHODS

ECHELON-3 is a randomized, double-blind, placebo-controlled, multicenter, phase 3 trial comparing BV + Len + R with placebo + Len + R in patients with R/R DLBCL. Patients received BV or placebo once every 3 weeks, Len once daily, and R once every 3 weeks. The primary end point was overall survival (OS), and secondary end points included investigator-assessed progression-free survival (PFS) and objective response rate (ORR). A prespecified interim analysis was performed after 134 OS events, with two-sided
P
= .0232 as the efficacy boundary.

RESULTS

Patients (N = 230) were randomly assigned to receive BV + Len + R (n = 112) or placebo + Len + R (n = 118). Two patients in the placebo arm did not receive treatment. With a median follow-up of 16.4 months, the median OS was 13.8 months with BV + Len + R versus 8.5 months with placebo + Len + R (hazard ratio, 0.63 [95% CI, 0.45 to 0.89]; two-sided
P
= .009). The median PFS was 4.2 months with BV + Len + R versus 2.6 months with placebo + Len + R (hazard ratio, 0.53 [95% CI, 0.38 to 0.73]; two-sided
P
< .001). The ORR was 64% ([95% CI, 55 to 73]; two-sided
P
< .001) with BV + Len + R and 42% (95% CI, 33 to 51) with placebo + Len + R; complete response rates were 40% and 19%, respectively. Treatment-emergent adverse events (AEs) occurred in 97% of patients in both arms. In both arms, the most common treatment-emergent AEs were neutropenia, thrombocytopenia, diarrhea, and anemia.

CONCLUSION
BV + Len + R demonstrated a statistically significant survival benefit with a manageable safety profile in heavily pretreated patients with R/R DLBCL.
Comparison of PREMM5 and PREMMplus Risk Assessment Models to Identify Lynch Syndrome
Authors: Biller Leah H. , Mittendorf Kate , Horiguchi Miki , Caruso Alyson , Chittenden Anu , Ukaegbu Chinedu , Uno Hajime , Syngal Sapna , Yurgelun Matthew B. 
Published: January 2025

PURPOSE
Clinical risk assessment models can identify patients with hereditary cancer susceptibility, but it is unknown how multigene cancer syndrome prediction models compare with syndrome-specific models in assessing risk for individual syndromes such as Lynch syndrome (LS). Our aim was to compare PREMMplus (a 19-gene cancer risk prediction model) with PREMM5 (a LS gene–specific model) for LS identification.

METHODS

We analyzed data from two cohorts of patients undergoing germline testing from a commercial laboratory (n = 12,020) and genetics clinic (n = 6,232) with personal and/or family histories of LS-associated cancer. Individual PREMMplus and PREMM5 scores were calculated for all patients. Using a score cutoff of

≥

2.5%, we calculated the sensitivity, specificity, positive predictive value, and negative predictive value (NPV) for identifying LS with each model. Overall ability to discriminate LS carriers from noncarriers was measured using receiver operating characteristic (ROC)-AUC.

RESULTS

PREMMplus had higher sensitivity than PREMM5 in the laboratory- (89.2% [95% CI, 84.4 to 93.0]
v
63.7% [95% CI, 57.0 to 70.0]) and clinic-based cohorts (90.5% [95% CI, 84.8 to 94.6]
v
60.8% [95% CI, 52.7 to 68.4]). NPV was ≥98.8% for both models in both cohorts. PREMM5 had superior discriminatory capacity to PREMMplus in the laboratory- (ROC-AUC, 0.81 [95% CI, 0.77 to 0.84]
v
0.71 [95% CI, 0.67 to 0.75]) and clinic-based cohorts (ROC-AUC, 0.79 [95% CI, 0.75 to 0.84]
v
0.68 [95% CI, 0.64 to 0.73]).

CONCLUSION
Both PREMM5 and PREMMplus demonstrated high NPVs (>98%) in LS discrimination across all patient cohorts, and both models may be used to identify individuals at risk of LS. The choice of which model to use can be based on the goals of risk assessment and patient population.
The Impact of MRI-Defined Extent of Resection Across Meningioma DNA Methylation Groups: Re-Evaluating Surgery in the Era of Meningioma Molecular Classification
Authors: Morshed Ramin A. , Nguyen Minh P. , Choudhury Abrar , Al-Adli Nadeem N. , Magill Stephen T. , Haddad Alexander F. , Mirchia Kanish , Lucas Calixto-Hope G. , Theodosopoulos Philip V. , McDermott Michael W. , Chen William C. , Raleigh David R. 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Extent of resection (EOR) is prognostic for meningioma outcomes. DNA methylation profiling can shed light on biological drivers and therapeutic vulnerabilities. The goal of this study was to re-evaluate the impact of EOR on clinical outcomes across meningioma DNA methylation groups.

METHODS:
Patients with sporadic meningiomas who underwent resection from a multicenter, international cohort were retrospectively reviewed. Gross vs subtotal resection (GTR vs STR, respectively) was determined based on postoperative MRI. The Kaplan-Meier method, log-rank statistics, and multivariable Cox proportional hazard analyses were performed to evaluate the impact of EOR on local freedom from recurrence (LFFR) and overall survival (OS).

RESULTS:
In total, 587 patients (Male: 195, Female: 392) underwent 644 surgeries for intracranial meningioma (GTR: 438, STR: 206), with 124 surgeries (19.3%) for recurrent intracranial meningiomas. The cohort included 375 (58.2%) World Health Organization (WHO) Grade 1, 202 (31.4%) WHO Grade 2, and 67 (10.4%) WHO Grade 3 meningiomas based on histological criteria. DNA methylation profiling was used to categorize meningiomas as Merlin-intact (N = 214, 33.2%), Immune-enriched (N = 236, 36.6%), or Hypermitotic (N = 194, 30.1%). GTR was associated with longer LFFR across all meningioma DNA methylation groups (Merlin-intact P < .0001; Immune-enriched P = .013; Hypermitotic P = .001) and was associated with longer OS for Hypermitotic meningiomas (P = .0022). In multivariable Cox proportional hazard analyses, EOR was significantly associated with LFFR across all DNA methylation groups and WHO grades but was significantly associated with OS only for Hypermitotic meningiomas (hazard ratio [GTR vs STR] 0.64, 95% CI 0.43-0.97, P = .034).

CONCLUSION:
MRI-defined GTR is associated with improved LFFR across all meningioma DNA methylation groups and improved OS for patients with Hypermitotic meningiomas. These data continue to support maximal safe resection when feasible and demonstrate how molecular classification systems complement rather than supersede the prognostic impact of surgery.