bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Retrospective Collection of EQ-5D-5L in US Patients with COVID-19
Authors: Sun Xiaowu , Fusco Manuela Di , Puzniak Laura , Coetzer Henriette , Zamparo Joann M. , Tabak Ying P. , Cappelleri Joseph C. 
Published: January 2023

AbstractBackgroundThe impact of COVID-19 goes beyond the acute phase of infection. It is imperative to evaluate health related quality of life (HRQoL) pre-COVID-19, but there is currently no evidence of the retrospective application of the EQ-5D-5L for COVID-19 studies.MethodsSubjects with ≥1 self-reported symptom and positive RT-PCR for SARS-CoV-2 at CVS Health US test sites were recruited between 01/31/2022-04/30/2022. On the day of enrollment which was around day 3 after testing positive, consented participants completed the EuroQol 5D-5L (EQ-5D-5L) questionnaire twice : a modified version where all the questions were past tense to retrospectively assess pre-COVID-19 baseline QoL, and the standard version in present tense to assess current HRQoL. Duncan’s new multiple range test was adopted for post analysis of variance pairwise comparisons of EQ-VAS means between problem levels for each of 5 domains. A linear mixed model was applied to check whether the relationship between EQ visual analog scale (VAS) and utility index (UI) was consistent pre-COVID-19 and during COVID-19. Matching-adjusted indirect comparison was used to compare pre-COVID-19 UI and VAS scores with those of the US population. Cohen’s d was used to quantify the magnitude of difference in means between two groups.ResultsOf 676 participants, 10.2% were age 65 or more years old, 73.2% female and 71.9% white. Diabetes was reported by 4.7% participants and hypertension by 11.2%. The pre-COVID-19 baseline mean UI was 0.924 and the mean VAS was 87.4. The estimated coefficient for the interaction of UI-by-retrospective collection indicator (0=standard prospective collection for Day 3 after COVID-19 testing, 1=retrospective for pre-COVID-19), -4.2 (SE: 3.2), P=0.197, indicates that retrospective collection does not significantly alter the relationship between EQ-VAS and UI. After adjusting for age, gender, diabetes, hypertension, and percent of mobility problems, predicted means of pre-COVID-19 baseline VAS and UI were 84.6 and 0.866, respectively. Both of these means were close to published US population norms (80.4 and 0.851) than those observed (87.4 and 0.924). After adjusting for age, gender, diabetes, and hypertension, 19.0% patients with COVID-19 had mobility problems, which was significantly lower than US population norm 25.2%, P<0.001. The calculated ES for UI and VAS were 0.15 and 0.39, respectively.ConclusionAt a group level the retrospectively collected pre-COVID-19 EQ-5D-5L is adequate and makes it possible to directly evaluate the impact of COVID-19 on HRQoL. Future studies are encouraged that are tailored to directly compare standard prospective assessment with retrospective assessment on the EQ-5D-5L during pre-COVID-19.
The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions
Authors: V. Nandana , I.W. Rathnayaka-Mudiyanselage , N.S. Muthunayake , A. Hatami , C.B. Mousseau , L.A. Ortiz-Rodríguez , J. Vaishnav , M. Collins , A. Gega , K.S. Mallikaarachchi , H. Yassine , A. Ghosh , J.S. Biteen , Y. Zhu , M.M. Champion , W.S. Childers , J.M. Schrader 
Published: January 2023

AbstractBacterial RNP bodies (BR-bodies) are non-membrane-bound structures that facilitate mRNA decay by concentrating mRNA substrates with RNase E and the associated RNA degradosome machinery. However, the full complement of proteins enriched in BR-bodies has not been defined. Here we define the protein components of BR-bodies through enrichment of the bodies followed by mass spectrometry-based proteomic analysis. We found 111 BR-body enriched proteins, including several RNA binding proteins, many of which are also recruited directly toin vitroreconstituted RNase E droplets, showing BR-bodies are more complex than previously assumed. While most BR-body enriched proteins that were tested cannot phase separate, we identified five that undergo RNA-dependent phase separationin vitro, showing other RNP condensates interface with BR-bodies. RNA degradosome protein clients are recruited more strongly to RNase E droplets than droplets of other RNP condensates, implying that client specificity is largely achieved through direct protein-protein interactions. We observe that some RNP condensates assemble with preferred directionally, suggesting that RNA may be trafficked through RNP condensates in an ordered manner to facilitate mRNA processing/decay, and that some BR-body associated proteins have the capacity to dissolve the condensate. Finally, we find that RNA dramatically stimulates the rate of RNase E phase separationin vitro, explaining the dissolution of BR-bodies after cellular mRNA depletion observed previously. Altogether, these results suggest that a complex network of protein-protein and protein-RNA interactions controls BR-body phase separation and RNA processing.HighlightsBR-body proteomics identified 111 proteins enriched in BR-bodies.BR-bodies associate with an interconnected network of RNP condensates.BR-body condensation is modulated by its interaction network.RNA is required for rapid BR-body condensation.Graphical AbstractSummary of the BR-body protein interactome. Lines between two protein circles represent a direct interaction.
DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity
Authors: Wang Pinhua , Sarkar Sunayana , Zhang Menghuan , Xiao Tingting , Kong Fenhua , Zhang Zhe , Balasubramanian Deepa , Jayaram Nandan , Datta Sayantan , He Ruyu , Wu Ping , Chao Peng , Zhang Ying , Washburn Michael P. , Florens Laurence , Nagarkar-Jaiswal Sonal , Jaiswal Manish , Mohan Man 
Published: January 2023

AbstractDYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking and microtubule assembly. DYRK1A is a critical regulator of organ growth; however, how it regulates organ growth is not fully understood. Here, we show that the knockdown ofDYRK1Aresults in reduced cell size, which depends on mTORC1. Using proteomic approaches, we found that DYRK1A interacts with the Tuberous sclerosis complex (TSC) proteins, namely TSC1 and TSC2, which negatively regulate mTORC1 activation. Further, we show that DYRK1A phosphorylates TSC2 at T1462, a modification known to inhibit TSC activity and promote mTORC1 activity. We also found that the reduced cell growth upon knockdown of DYRK1A can be rescued by overexpression of RHEB, an activator of mTORC1. Our findings suggest that DYRK1A inhibits TSC complex activity through inhibitory phosphorylation on TSC2, thereby promoting mTORC1 activity. Further, using theDrosophilaneuromuscular junction as a model, we show that themnb,the fly homologues ofDYRK1A, is rescued by RHEB overexpression, suggesting a conserved role ofDYRK1Ain TORC1 regulation.
Preclinical Evaluation of a Novel Single-Shot Pulsed Field Ablation System for Pulmonary Vein and Atrial Ablation
Authors: Aryana Arash , Ji Sang Yong , Hata Cary , de la Rama Alan , Nguyen Ken , Panescu Dorin 
Published: January 2023

AbstractBACKGROUNDPulsed field ablation (PFA) is a non-thermal ablative strategy that achieves cell death via electroporation. We investigated the preclinical safety and efficacy of PFA using two novel 8-French, 16-electrode spiral PFA/mapping catheters (CRC EP, Inc).METHODSBipolar PFA (>1.8 kV) was performed using 30 s, single-shot, QRS-gated applications. Ninety-four atrial structures were ablated in 23 swine, 1 canine, and 1 ovine, including right and left atria and atrial appendages, pulmonary veins, and superior and inferior (IVC) vena cavae. Additionally, we examined the impact of PFA on the phrenic nerve in 14 swine and on a deviated esophagus during ablation from inside the IVC in 5 swine.RESULTSAll applications were single-shot without repositioning the catheter. Minimal microbubbling was observed without significant skeletal muscle twitching/activation (mean acceleration: 0.05 m/s2). There was marked reduction in the post-versus pre-PFA atrial electrogram amplitude (0.17±0.21 mVvs. 1.18±1.08 mV; P<0.0001). Durable conduction block was demonstrated up to 3 months in all targeted tissues. Lesions were contiguous and transmural, measuring 25±9 mm x 21±7 mm without any thermal effects. Magnetic resonance, gross, and histologic examinations of the brain, rete mirabile and kidneys revealed no thromboembolism. No acute/long-term phrenic nerve dysfunction was encountered. Though within 2 hours of ablation, histologic examinations of the esophagus revealed acute PFA-related changes in the muscular layer, these completely resolved by 21±5 days.CONCLUSIONA novel, single-shot, spiral PFA system is capable of safely creating large, durable atrial lesions without significant adverse effects on the phrenic nerve or the esophagus.
Impact of ultrasonic vibration power and tool pin profile on mechanical and microstructural behaviour of friction stir welded dissimilar aluminium alloy joints
Authors: K.P. Yuvaraj , J. Joshua Gnana Sekaran , A. Shanmugam 
Published: January 2023

Purpose
The purpose of this paper is to investigate the impact of ultrasonic vibration (UV) and tool pin profile on mechanical properties and microstructural behaviour of AA7075-T651 and AA6061-T6 joints was analysed.

Design/methodology/approach
The joints were fabricated using three different tool pin profiles such as cylindrical, square and triangle. For each tool pin profile, two different UV powers of 1.5 kW and 2 kW were used.

Findings
On both the advancing and retreating sides of the weld, the thermo-mechanically affected zone has the lowest microhardness. In all joints, the tensile fracture locations match to the minimum hardness values. Field emission scanning electron microscope fractography of tensile tested specimens reveals heterogeneous modes of brittle, shear and ductile fracture. Three-point bending analysis was performed to determine the ductility and soundness of the weld joint. The acoustic softening effect of UV, as well as the static and dynamic ratio of tool pin profile, plays an important role in determining the material flow and mechanical behaviour of the joint.

Practical implications
Dissimilar aluminium joining fascinates many applications like aircraft, aerospace, automobiles, ship building and electronics, where fusion welding is a very intricate process because of the deviation in its physical and chemical properties.

Originality/value
From this study investigation, it is found that the square pin profiled tool with 2 kW UV power produces metallurgical defect-free and mechanically sound weld with maximum tensile strength, hardness and bending load of 297 MPa, 151HV and 3.82 kN, respectively.
Architectural pedagogy for the Anthropocene: theory, critique and typological urbanism
Authors: McEwan Cameron 
Published: January 2023

PurposeThe aim of this article is to develop an architectural pedagogy for the Anthropocene. The author reflect on a project within a postgraduate architectural theory module to address the following questions: How can architectural pedagogy articulate critical modes of production that contribute to quality education in the time of the Anthropocene? What are the ideas, values and practices needed?Design/methodology/approachThe method employed is close reading of texts focussed on three areas: critical theory and pedagogy, political theory and the Anthropocene, and architectural theory and typological urbanism. These theoretical narratives are placed in dialogue with a reflection on a design research pedagogical project. The theoretical narratives and design research project seek to articulate the multidimensionality of critical education. The methodology enacted in the paper performs the pedagogy of the classroom.FindingsThe study yields compelling conclusions regarding the potential for rethinking the idea of typology under the pressure of the Anthropocene and of critical pedagogy combined with design research to take positions on urgent political and social matters. The author concludes with a toolkit of concepts, values and knowledge practices.Originality/valueAt a time when disciplines tend towards discrete specialisation, while the need for knowledge production is ever more transdisciplinary, this paper develops inventive techniques and conceptual frameworks for supporting approaches where different fields and ideas make contact as a collective task in the era of the Anthropocene. It updates theories of typology to address contemporary pressures.
Digital data sets management in university libraries: challenges and opportunities
Authors: Shah Naimat Ullah , Naeem Salman Bin , Bhatti Robina 
Published: January 2023

Purpose
The study aims to identify the prospects and challenges associated with current practices regarding digital data sets management in university libraries in Pakistan.

Design/methodology/approach
A cross-sectional survey approach was used to collect the data from library and information science (LIS) professionals working in public sector university libraries in Pakistan. A four-part questionnaire was used to collect the data from the respondents. The collected data from 371 participants were analyzed using a statistical package for social sciences (SPSS-24 version) and analysis of moment structure (AMOS-24).

Findings
LIS professionals are better placed to support digital data management practices, such as finding, collecting, assessing and analyzing digital data sets and making digital data publicly discoverable and accessible via open access. In spite of this, a lack of leadership support, interest and cooperation among university departments and the absence of a data management plan, policies and procedures were reported as significant challenges.

Practical implications
To meet the needs of data users, LIS professionals must become knowledgeable about managing and reusing digital data sets. Due to the demands of the information society, university librarians need to learn about data-centric practices that can enhance research outputs and provide new insights.

Originality/value
This research paper is extracted from a PhD dissertation to present a contemporary picture of library data management services and the challenges LIS professionals face to provide possible solutions.
Blockchain and the carbon credit ecosystem: sustainable management of the supply chain
Authors: Basu Preetam , Deb Palash , Singh Akhilesh 
Published: January 2023

Purpose
Businesses must now track the complicated supply chains of their products, which involve different manufacturers and suppliers. However, because supply chains are scattered across multiple countries and involve many institutions, it becomes an overwhelming practical challenge to ensure transparent recording and reporting of greenhouse gas emissions. The myriad issues necessitate a technological solution that will improve supply chain transparency, assist in managing carbon assets and allow all parties to obtain credible information on carbon output. As a potential solution, this study offers a unique architecture that effectively combines “blockchain technology” with the carbon supply chain of a multi-institution business network.

Design/methodology/approach
This research and proposed framework are based on publicly available reports on carbon emissions tracking, sustainability, carbon trade and emerging blockchain technologies. The authors also interviewed industry experts to obtain their input and feedback.

Findings
Businesses must support the pledges made by their respective governments towards meeting the objectives of the Paris Agreement. Although the emissions trading system encourages businesses to move in this direction, it can be challenging for them to efficiently manage their carbon assets owing to issues such as lack of standardised methods for tracking emissions across suppliers and manufacturers and the fragmentation of carbon markets. The carbon supply chain can maintain a record of the chronological flow of carbon emissions and eventually of all carbon assets by integrating a centralised ledger system based on blockchain technology.

Originality/value
Global warming, climate change and carbon emissions are among humanity’s pressing problems today. To achieve net zero emissions by the middle of the 21st century, emissions must be drastically reduced. Global supply chains have a crucial role to play in this context. This article provides a blockchain-based technology framework for carbon emissions visibility and tracking. The authors believe such a platform will provide critical visibility and tracking support to globally dispersed supply chains, moving a step closer towards carbon emissions control and net zero operations.
Knowledge management in museums: enhancing organizational performance and public value
Authors: Vakharia Neville , Poole Alex H. 
Published: January 2023

PurposeThis study examines the enabling factors and practices that foster knowledge management in museums and the impact of those factors and practices on museums' performance and public value.Design/methodology/approachThe authors conducted an exploratory survey of senior leaders of 191 small and mid-sized museums in the United States. The survey tested a novel conceptual model that integrates the constructs of knowledge management enablers, knowledge management orientation and organizational performance. Descriptive and inferential statistical analyses of survey data were conducted to identify both the presence and dimensions of these constructs as well as the nature of the relationships among them.FindingsThe results of this study identified strong and significant predictive relationships between the constructs of its novel conceptual model. However, findings also identified key gaps in how museums create, manage and share organizational knowledge. These gaps limit their organizational performance and their ability to create public value. The authors identify specific factors and practices that enable museums to improve their organizational performance and increase their public value.Originality/valueAs the first empirical study of knowledge management enablers and knowledge management orientation in museums, this research not only adapts the study of these constructs to the museum sector, but it develops a novel conceptual model that links these constructs to multiple dimensions of a museum's organizational performance and public value. This research sets the stage for new study of knowledge management in museums; it also provides valuable insights for museum leaders.
The effect of key audit matters on the audit report lag: evidence from Jordan
Authors: Abdullatif Modar , Alzebdieh Rami , Ballour Saeed 
Published: January 2023

Purpose
This paper aims to explore the potential effect of key audit matters (KAM) on the audit report lag (ARL). In particular, it aims to discover whether the number of KAMs reported by an audit firm in Jordan is related to the length of its ARL.

Design/methodology/approach
The authors analysed data from the first three years of KAM reporting in Jordan (2017–2019) for 194 public listed Jordanian companies to examine the relation between the number of KAMs and the ARL, taking into account several control variables related to the Jordanian context.

Findings
This study found that there is no statistically significant relation between the number of KAMs reported by Jordanian audit firms and their ARLs, suggesting that the KAM reporting in Jordan is somewhat superficial, with the selection of what is actually reported as a KAM not directly related to the efforts needed to deal with its concerns. However, this study also found statistically significant positive relations between the ARL and each of audit fees, audit firm size, the issuance of a qualified audit opinion and company leverage and a statistically significant negative relation between the ARL and company profitability.

Originality/value
This is one of the very few studies to cover the potential relation between KAM reporting and the ARL. In a developing country context characterised by limited demand for an external audit of high quality, this study finds that auditors may decouple on their reporting of KAMs by not actually making significant efforts to deal with them.
Determinants of efficient last-mile delivery: evidence from health facilities and Kaduna Health Supplies Management Agency
Authors: Miko Nuraddeen Usman , Abbas Usman 
Published: January 2023

Purpose
Africa has been identified as an area where higher mortality happens due to un-accessibility to health care, drugs and other health facilities. Nigeria, as one of the African countries, is not excluded from such difficulties. This study aims to examine the determinants of efficient last-mile delivery at selected health facilities and the Kaduna State Health Supplies Management Agency (KADSHMA).

Design/methodology/approach
The study sourced data from KADSHMA and the health facilities’ staff, with a total of 261 observations used. Likewise, the respondents were picked from warehouses of each health facility and KADSHMA. The data was analysed using the partial least square structural equation modelling analysis to estimate the relationship among the variables of the study.

Findings
The study’s findings revealed that all five variables of the study (i.e. determinants) were significantly affecting the efficient last-mile delivery. Four constructs (delivery cost [DC], delivery time [DT], mode of delivery [MD] and facilities technology [FT]) have shown a positive and significant association with efficient last-mile delivery, whereas one variable (product mix [PM]) indicated a negative and significant association with efficient last-mile delivery. The study concludes that DC, DT, MD, FT and PM played significant roles in efficient last-mile delivery.

Research limitations/implications
The study provides that specific means of transportation should always be on standby to transport health supplies. Time schedules should always be prepared and adhered to when transporting health supplies to the facilities, and each facility should network with robust technology to ease communication in terms of order and order planning. Additionally, facilities should try as much as possible to reduce the varieties of products when ordering health supplies, as it will increase the efficiency of the delivery.

Originality/value
To the best of the authors’ knowledge, this study is the first of its kind that considered these five variables (DC, DT, MD, FT and PM) with impact on the last-mile delivery in one model, especially in the Nigerian case. This is a great contribution to knowledge, more importantly, to the last-mile delivery of the health sector. The result confirmed the importance of these determinants (DC, DT, FT and PM) of last-mile delivery efficiency in saving lives.