bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the regularities of the influence of air heat curtains on the energy balance of livestock premises
Authors: Tikhomirov D A , Khimenko A V , Trunov S S , Kuzmichev A V 
Published: February 2023

Abstract
The use of air heat curtains allows you to limit the amount of cold air incoming the room through open gates or doors, as well as to heat it up. The article considers the influence of air heat curtains on the energy balance of livestock premises. The calculation method is presented and the main aerodynamic characteristics of an air curtain installed in a calf house for 50 animals are substantiated. The main heat and power and structural parameters of the air curtain have been determined. On the basis of the heat balance of the calf barn, its modes of operation are substantiated. It has been established that the power consumption for the fan drive during the operation of the air curtain is significantly less than the cost of thermal energy to compensate for the air temperature in the room from the inflow of cold air. The technical and economic calculation showed the effectiveness of the use of air heat curtains in microclimate systems for various livestock facilities of agricultural production.
Ensuring the reliability of adjusting the clearance of a four-wheel tractor
Authors: Akhmetov A A , Akhmedov Sh A , Allanazarov M A , Asamov R H 
Published: February 2023

Abstract
In cotton growing, three-wheeled tractors are used for inter-row processing of cotton. Despite good agrotechnical permeability, they have significant specific disadvantages associated with low resistance, the impossibility of using them for transport work and, most importantly, a negative technogenic impact on the soil. To eliminate these shortcomings of a three-wheeled tractor, “DTCAE LLC” developed a design for a four-wheeled tractor with adjustable ground clearance. Clearance adjustment, which is carried out by a screw mechanism, selected in such a way that the force of the operator would be sufficient to create a torque to drive it, but at the same time there would be no spontaneous rotation of the screw under the influence of axial force arising from the gravity of the tractor. The article presents a method for calculating the parameters of a screw-nut pair, which excludes spontaneous rotation of the screw under the influence of axial force arising from the gravity of the tractor and thereby ensures the reliability of the screw mechanism for adjusting the tractor clearance.
Inequality Regimes in Africa From Pre-Colonial Times to the Present
Authors: Frankema Ewout , de Haas Michiel , van Waijenburg Marlous 
Published: February 2023

ABSTRACT
While current levels of economic inequality in Africa receive ample attention from academics and policymakers, we know little about the long-run evolution of inequality in the region. Even the new and influential ‘global inequality literature’ that is associated with scholars like Thomas Piketty, Branko Milanovic, and Walter Scheidel has had little to say about Africa so far. This paper is a first effort to fill that void. Building on recent research in African economic history and utilizing the new theoretical frameworks of the global inequality literature, we chart the long-run patterns and drivers of inequality in Africa from the slave trades to the present. Our analysis dismantles mainstream narratives about the colonial roots of persistent high inequality in post-colonial Africa and shows that existing inequality concepts and theories need further calibration to account, among others, for the role of African slavery in the long-run emergence and vanishing of inequality regimes.
Validation of Linear Range HER2/Estrogen Receptor/Progesterone Receptor IHControls for Daily Quality Assurance
Authors: Sompuram Seshi R , Vani Kodela , Ryan Lori , Johnson Corissa , Szabolcs Matthias , Peruyero Leonore , Balaton André , Pierrot Sandrine , Joseph Lija , Pilichowska Monika , Naber Stephen , Goldsmith Jeffrey , Green Samantha , Bogen Steve A 
Published: February 2023

AbstractObjectivesTo evaluate a new US Food and Drug Administration (FDA)–cleared immunohistochemistry (IHC) control (IHControls [Boston Cell Standards]) comprising peptide epitopes for HER2, estrogen receptor (ER), and progesterone receptor (PR) attached to cell-sized microspheres and to compare its performance against conventional tissue controls.MethodsIHControls and tissue/cell line controls for HER2, ER, and PR were compared side by side daily at 5 clinical IHC laboratories for 1 to 2 months. Separately, the sensitivity of the 2 types of controls was evaluated in simulated IHC assay failure experiments by diluting the primary antibody. Additional evaluations included lot-to-lot manufacturing reproducibility of 3 independent lots and specificity against 26 antigenically irrelevant IHC stains.ResultsSide-by-side testing revealed a 99.6% concordance between IHControls and tissue controls across 5 IHC laboratories and 766 individual evaluations. Three discordant quality control events were the result of operator error. Simulated assay failure data showed that both IHControls and tissue controls are similarly capable of detecting IHC staining errors. Manufacturing reproducibility of IHControls showed less than 10% variability (coefficient of variation). No cross-reactions were detected from 26 antigenically irrelevant IHC stains.ConclusionsIHControls, the first FDA-cleared IHC controls, can sensitively and accurately detect IHC assay problems, similar to tissue controls.
Association of Sedentary Time With Cardiocerebral Deaths: A Prospective Cohort Study
Authors: Zhou Wei , Zhu Ling-juan , Wang Tao , Bao Hui-hui , Cheng Xiao-shu 
Published: February 2023

Abstract

Background
To explore the association of sedentary time with cardiocerebral deaths.

Methods
A total of 12,608 community residents aged 35 years or above in Jiangxi Province who took part in “the study on prevalence of major cardiovascular diseases and key techniques in China” during 2013–2014 were enrolled in this prospective, observational cohort study. Sedentary time was obtained through baseline questionnaire, and all death events were collected by telephone follow-up, information report from the departments of public health in township health centers and village doctors, and death surveillance system of Jiangxi Center for Disease Control and Prevention. Cox proportional hazard regression model was used to evaluate the association of sedentary time with cardiocerebral deaths.

Results
A total of 11,744 participants were included in final analysis. During an average 5.4 years of follow-up (63,298 person-year), 796 all-cause deaths occurred, including 373 cardiocerebral deaths. The difference of cardiocerebral death rate was statistically significant in 3 groups of &lt;6 h/d (2.9%), 6–8 h/d (3.9%), and &gt;8 h/d (5.4%). Kaplan–Meier curve showed that there was a significant difference in the cumulative mortality among the 3 groups (log rank χ2 = 17.27, P &lt; 0.01). Cox regression analysis showed that after adjusting for relevant confounding factors, older age, high diastolic pressure and body mass index, male, country of residence, unemployment, and long sedentary time were risk factors for cardiocerebral deaths. Compared with the &lt;6 h/d group, the risk of cardiocerebral deaths increased by 68.3% (HR = 1.683, 95% CI: 1.186–2.388) for participants with sedentary time of &gt;8 h/d.

Conclusions
Long sedentary time independently increases the risk of cardiocerebral deaths.
Preventing medication history errors in high-risk patients: Impact of California Senate Bill 1254
Authors: Tu Thanh , Stephens Sarah , Bajorek Sarah , Leang Donna , Nguyen Daniel , Shane Rita 
Published: February 2023

Abstract

Purpose
California Senate Bill (SB) 1254 (effective January 1, 2019) requires pharmacy staff at acute hospitals with more than 100 beds to obtain a medication profile for high-risk patients upon hospital admission. This multicenter study sought to evaluate the statewide impact of California SB 1254 by capturing the errors intercepted and harm prevented as a result of the passage of the bill.

Methods
This was a multicenter, prospective, observational study conducted at 11 hospitals in California for 6 consecutive weeks between January 2020 and March 2020. Participating sites captured medication history errors identified among high-risk patients using organization-specific criteria. Errors were categorized by type and ranked for severity of potential or actual harm based on the modified National Coordinating Council for Medication Error Reporting and Prevention (NCC MERP) categories.

Results
Study sites had an average daily census of 180 to 800 patients. Approximately 94% (n = 2,554) of medication histories conducted disclosed at least 1 error. Approximately 54% (n = 1,474) of histories disclosed at least 1 serious or potentially life-threatening error. Approximately 6 errors were identified and prevented per patient (95% CI, 5.62-6.01 errors per patient), and 1 in 4 errors (25%) was categorized as potentially serious or life-threatening.

Conclusion
Among high-risk patients, pharmacy-led medication histories significantly reduced medication errors. If not intercepted, these errors would have likely resulted in substantial morbidity and mortality. Future research should evaluate opportunities to standardize high-risk criteria to support patient prioritization and allocation of resources.
Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS
Authors: Yang Zi , Liu Fenting , Bai Jiali , Ye Zhenhong , Yin Jingwen , Peng Tianliu , Shan Hongying , Yu Yang , Zhou Ping , Li Rong 
Published: February 2023

Abstract
To investigate the expression profiles of circular RNAs (circRNAs) in the endometria of women with polycystic ovary syndrome (PCOS) and to explore the role of aberrant circ_0115118 expression in endometrial dysfunction in patients with PCOS. CircRNA microarray hybridization and bioinformatic analyses were performed to determine the expression patterns of circRNAs in the endometria of patients with or without PCOS, the expression of target circRNA was evaluated by real-time polymerase chain reaction (PCR). Cell counting kit-8 and Transwell assays were used to detect cellular proliferative, invasive, and migratory capacities. The influence of the circRNA on decidualization was explored by real-time PCR. Animal models were established to investigate the regulatory effect of the circRNA on embryo implantation. Downstream microRNAs and genes were predicted using bioinformatic websites and verified by dual-luciferase reporter assays, real-time PCR, and western blotting. In the endometria of patients with PCOS, there were 113 differentially expressed circRNAs in the secretory phase and 1119 differentially expressed circRNAs in the proliferative phase. The expression of circ_0115118 was significantly higher in endometrial stromal cells during the proliferative phase in patients with PCOS, leading to inhibition of cellular mobilization and embryo implantation. In addition, circ_0115118 exerted effects by sponging miR-138-1-3p, subsequently increasing the expression of WD repeat and FYVE domain-containing protein 2 (WDFY2). Circ_0115118 expression is dysregulated in the endometria of patients with PCOS and adversely affects endometrial function. Our findings reveal that circ_0115118 may be a potential therapeutic target to improve pregnancy outcomes in women with PCOS.
AngioVac debulking of a tricuspid valve mass following complex lead extraction in a rare case of Austrian syndrome: a case report
Authors: Middleton Megan , McDaniel Graham , Attanasio Steve 
Published: February 2023

AbstractBackgroundThe European Society of Cardiology recommends surgical valvular intervention in right-sided infective endocarditis for persistent vegetations &gt;20 mm after recurrent pulmonary emboli, infection with a difficult-to-eradicate organism with &gt;7 days of persistent bacteraemia, or tricuspid regurgitation causing right-sided heart failure. In this case report, we discuss the role of percutaneous aspiration thrombectomy for a large tricuspid valve (TV) mass as an alternative to surgery due to poor surgical candidacy in a patient with Austrian syndrome, following a complex implantable cardioverter defibrillator (ICD) device extraction.Case summaryA 70-year-old female presented to the emergency department after being found acutely delirious at home by family. Infectious workup was notable for growth of Streptococcus pneumoniae in the blood, cerebrospinal, and pleural fluid. Transoesophageal echocardiogram was pursued in the setting of bacteraemia and revealed a mobile mass on the TV consistent with endocarditis. Given the size and embolic potential of the mass and eventual need for ICD replacement, the decision was made to pursue extraction of the valvular mass. The patient was a poor candidate for invasive surgery, so we opted to perform percutaneous aspiration thrombectomy. After the ICD device was extracted, the TV mass was successfully debulked using the AngioVac system without complication.DiscussionPercutaneous aspiration thrombectomy of right-sided valvular lesions has been introduced as a minimally invasive approach to avoid or delay valvular surgery. When intervention is indicated for TV endocarditis, AngioVac percutaneous thrombectomy may be a reasonable operative approach, particularly in patients who are at high risk for invasive surgery. We report a case of successful AngioVac debulking of a TV thrombus in a patient with Austrian syndrome.
Unexpected paradoxical embolization following catheter-directed thrombectomy with the FlowTriever™ system in a patient with pulmonary embolism: a case report
Authors: Uecker Nicola Anne , Rosenkranz Stephan , Bunck Alexander , Tichelbäcker Tobias 
Published: February 2023

AbstractBackgroundThe optimal therapy for patients suffering from acute pulmonary embolism (PE) classified as intermediate-high risk still needs to be identified. Catheter-directed thrombectomy (CDTE) is a safe procedure to reduce thrombus burden immediately. The lack of randomized trials is one reason: catheter-directed thrombolysis (CDT) has not yet received a clear recommendation in our guidelines. Herein, we report an unexpected event in the course of a patient with PE treated with CDTE using the FlowTriever™ system, the only FDA-approved catheter system for percutaneous mechanical thrombectomy regarding this indication.Case SummaryA 57-year-old male presented with dyspnoea at the emergency department of our university hospital. The computed tomography (CT) scan showed bilateral PE, and ultrasound of the left lower limb revealed deep venous thrombosis. According to the current ESC guidelines, he was classified intermediate-high risk. We performed bilateral CDTE. On the first and third day post-intervention, our patient presented neurological deficits. Whereas the first CT scan of the cerebrum remained normal, the CT scan at Day 3 showed demarcated embolic stroke. Further imaging diagnostic gave evidence to an ischemic lesion in the left kidney. Transesophageal echocardiography revealed a patent foramen ovale (PFO) as the origin of paradoxical embolism and thus mechanism of both ischemic lesions. Compliant to the current recommendations, percutaneous PFO closure was performed. Our patient recovered properly without any sequelae.DiscussionWhether the deep venous thrombosis is the source of embolization or the catheter-directed retrieval of clots may have transported clot material to the right atrium which further on embolized systemically will remain unclear. Yet, we have to consider it as a potential complication in catheter-directed treatment of PE in patients with a PFO.
Rapid evolution of sex role specialization in a hermaphrodite under sex-limited selection
Authors: Nordén Anna K , Ramm Steven A , Abbott Jessica K 
Published: February 2023

AbstractThe evolution of separate sexes from hermaphroditism is thought to have occurred independently many times, and may be linked to the evolution of sex chromosomes. Even though we have a good understanding of the theoretical steps in the evolution of sex chromosomes from a hermaphrodite ancestor, the initial stages are still hard to study in animals because many well-studied animal sex chromosome systems are old. We addressed this problem by experimentally selecting a hermaphrodite via sex-limited experimental evolution for several generations, simulating the early stages in the evolution of a sex chromosome. After 14 generations, a fitness assay revealed evidence of incipient sex role specialization in the female-selected lines, presumably reflecting the release from constraints usually imposed by selection on the other sex role. Importantly, however, this was not simply explained by morphology because testis and ovary sizes did not diverge among treatments. There was no evidence of a change in the male-selected lines. Our study shows that sex role specialization can occur rapidly as a result of sex-limited selection, which is consistent with genetic constraints between sex roles, and in line with the first predicted steps toward the evolution of a new sex chromosome system.
Distributions of Resonances of Supercritical Quasi-Periodic Operators
Authors: Liu Wencai 
Published: February 2023

Abstract
We discover that the distribution of (frequency and phase) resonances plays a role in determining the spectral type of supercritical quasi-periodic Schrödinger operators. In particular, we disprove the 2nd spectral transition line conjecture of Jitomirskaya in the early 1990s.
The Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination and Infection on Neutralizing Antibodies: A Nation-wide Cross-sectional Analysis
Authors: Althaus Thomas , Landier Jordi , Zhu Feng , Raps Hervé , Dejoux Olivier , Costantini Alizée , Lavagna Christian , Rampal Patrick , Mattiuzzo Giada , Xu Shuting , Wang Lin-Fa , Voiglio Eric J 
Published: February 2023

Abstract

Background
Neutralising antibodies (nAbs) play a critical role in the protection against severe COVID-19. In the era of vaccine boosters and repeated SARS-CoV-2 outbreaks, identifying individuals at risk represents a public health priority.

Methods
Relying on the Monaco COVID Public Health Programme, we evaluated nAbs from July 2021-June 2022 in 8,080 SARS-CoV-2 vaccinated and/or infected children and adults, at their inclusion visit. We stratified by infection status and investigated variables associated with nAbs using a generalised additive model.

Results
Infected and vaccinated participants had high and consistent nAbs (&gt;800 IU/mL), which remained stable over time since injection, regardless of the number of vaccine doses, body mass index, sex, or age. By contrast, uninfected participants showed larger variability (two doses [V2] median 157.6; interquartile range [IQR] 43.3-439.1 IU/mL) versus three doses [V3] median 882.5; [829.5-914.8] IU/mL). NAbs decreased by 20% per month after V2 (adjusted ratio 0.80; 95%CI [0.79-0.82]), but remained stable after V3 (adjusted ratio 0.98; 95%CI [0.92-1.05]).

Conclusions
Hybrid immunity provided stable, high and consistent nAbs over time. The benefit of boosters was marked to restore decaying nAbs in uninfected participants. NAbs could identify individuals at risk of severe COVID-19 and provide more targeted vaccine boosters’ campaigns.
In vivoefficacy & resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam or meropenem using human-simulated regimens versusAcinetobacter baumannii
Authors: Gill Christian M , Santini Debora , Takemura Miki , Longshaw Christopher , Yamano Yoshinori , Echols Roger , Nicolau David P 
Published: February 2023

AbstractObjectiveEvaluate the in vivo efficacy and resistance prevention of cefiderocol in combination with ceftazidime/avibactam, ampicillin/sulbactam and meropenem using human-simulated regimens (HSR) in the murine infection model.MethodsIn total, 15 clinical A. baumannii were assessed: cefiderocol MICs, 2 mg/L (previously developed resistance on therapy), n = 3; 8 mg/L, n = 2; ≥32 mg/L, n = 10 (including VEB and PER-harbouring isolates). Mice received inactive control, cefiderocol, cefiderocol + ceftazidime/avibactam (C-CZA), cefiderocol + ampicillin/sulbactam (C-SAM) or cefiderocol + meropenem (C-MEM) HSRs. The mean change in log10 cfu/thigh compared with starting inoculum was assessed. Resistance development on treatment was a &gt;4-fold increase in MIC relative control animals. In vitro activities of combinations were assessed by disc stacking.ResultsAgainst cefiderocol-non-susceptible isolates, combinations produced significant kill with C-CZA −3.75 ± 0.37 reduction in log10 cfu/thigh, C-SAM produced −3.55 ± 0.50 and C-MEM produced −2.18 ± 1.75 relative to baseline. Elevated MICs in cefiderocol treated animals occurred in three out of three isolates with MICs of 2 mg/L. Of these isolates, one developed elevated MICs with C-MEM compared with none treated with C-CZA or C-SAM. Disc stacking with C-CZA or C-SAM returned all isolates to at least the CLSI intermediate breakpoint, which may correlate with in vivo efficacy.ConclusionsAgainst cefiderocol-non-susceptible isolates, cefiderocol + ceftazidime/avibactam or ampicillin/sulbactam HSR produced in vivo kill against all 12 cefiderocol-non-susceptible isolates. Cefiderocol with ceftazidime/avibactam or ampicillin/sulbactam prevented the development of resistance during treatment against cefiderocol-high-end-susceptible isolates with a propensity for resistance on therapy. These data support the clinical evaluation of cefiderocol with ceftazidime/avibactam or ampicillin/sulbactam against A. baumannii, including multi-drug-resistant isolates.
Improving Statistical Matching when Auxiliary Information is Available
Authors: Moretti Angelo , Shlomo Natalie 
Published: February 2023

AbstractThere is growing interest within National Statistical Institutes in combining available datasets containing information on a large variety of social domains. Statistical matching approaches can be used to integrate data sources through a common set of variables where each dataset contains different units that belong to the same target population. However, a common problem is related to the assumption of conditional independence among variables observed in different data sources. In this context, an auxiliary dataset containing all the variables jointly can be used to improve the statistical matching by providing information on the correlation structure of variables observed across different datasets. We propose modifying the prediction models from the auxiliary dataset through a calibration step and show that we can improve the outcome of statistical matching in a variety of settings. We evaluate the proposed approach via simulation and an application based on the European Union Statistics for Income and Living Conditions and Living Costs and Food Survey for the United Kingdom.