bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal Fluid HIV-1 Escape in Patients With Neurocognitive Symptoms: Pooled Data From a Neuro-HIV Platform and the NAMACO Study
Authors: Filippidis Paraskevas , Damas Jose , Viala Benjamin , Assal Frederic , Nawej Tshikung Olivier , Tarr Philip , Derfuss Tobias , Oberholzer Michael , Jelcic Ilijas , Hundsberger Thomas , Sacco Leonardo , Cavassini Matthias , Du Pasquier Renaud , Darling Katharine E.A. ,   the NAMACO study group, Swiss HIV Cohort Study
Published: March 2023

Background:
Despite modern antiretroviral therapy, human immunodeficiency virus-1 (HIV-1) ribonucleic acid (RNA) escape into the cerebrospinal fluid (CSF) may occur. We examined the prevalence of and factors associated with CSF HIV-1 escape among people living with HIV (PLWH) in Switzerland.

Setting:
The Neurocognitive Assessment in the Metabolic and Aging Cohort study is an ongoing, prospective, longitudinal, multicenter study within the Swiss HIV Cohort Study. The neuro-HIV platform is a multidisciplinary, single-day outpatient consultation at Lausanne University Hospital.

Methods:
We pooled data from the Neurocognitive Assessment in the Metabolic and Aging Cohort study and the neuro-HIV platform participants who underwent lumbar puncture between 2011 and 2019. Both patient groups had neurocognitive symptoms. Cerebrospinal fluid HIV-1 escape was defined as the presence of quantifiable CSF HIV-1 RNA when plasma HIV-1 RNA was suppressed or CSF HIV-1 RNA greater than plasma HIV-1 RNA when the latter was detectable.

Results:
Of 1166 PLWH assessed, 288 underwent lumbar puncture. Cerebrospinal fluid HIV-1 escape was observed in 25 PLWH (8.7%) of whom 19 (76%) had suppressed plasma HIV-1 RNA. Characteristics of PLWH were comparable whether they had CSF HIV-1 escape or not, including comorbidities, time since HIV diagnosis (15 vs 16 years, P = 0.9), median CD4 nadir (158.5/mm3 vs 171/mm3, P = 0.6), antiretroviral CSF penetration-effectiveness score (7 vs 7 points, P = 0.8), and neurocognitive diagnosis based on Frascati criteria and radiological findings.

Conclusions:
In this large pooled sample of PLWH with neurocognitive symptoms, CSF HIV-1 escape occurred in 8.7% of PLWH. People living with HIV with CSF HIV-1 escape presented no distinctive clinical or paraclinical characteristics. We conclude that lumbar puncture is unavoidable in confirming CSF HIV-1 escape.
Partial Response Upon Peptide Receptor Radionuclide Therapy in a Highly Proliferative Pancreatic Neuroendocrine Tumor
Authors: Weich Alexander , Serfling Sebastian E. , Rowe Steven P. , Solnes Lilja B. , Buck Andreas K. , Higuchi Takahiro , Werner Rudolf A. 
Published: March 2023

Abstract
We report on a patient diagnosed with an aggressive pancreatic neuroendocrine tumor (NET G3; Ki67 = 60%), who underwent pancreatic resection with partial removal of liver lesions. The patient refused chemotherapy. Dual-tracer imaging with 18F-FDG and somatostatin receptor (SSTR)-targeted PET/CT was conducted. Radiotracer accumulation on both imaging modalities in bilobar hepatic lesions was observed. “Cold” somatostatin analogues with four cycles of peptide receptor radionuclide therapy (PRRT) were initiated, leading to partial response. Even in highly proliferative but differentiated G3 NET (Ki67>55%), SSTR expression in sites of disease should be evaluated, which may then allow PRRT, even as first-line systemic treatment.
Chest Wall Keloids Depicted by 18F-Piflufolastat PET/CT Imaging
Authors: Nguyen Amanda , Martinez Felipe , Nguyen Ba D. 
Published: March 2023

AbstractKeloids are pathological scars from exuberant fibroproliferative collagen response and excessive extracellular matrix production usually extending beyond the original wound margins. Although keloids are mostly of dermatological concern, they could be incidentally depicted on scintigraphic planar and PET/CT imaging and could mimic other types of skin diseases. The authors present a case of chest wall keloids documented on18F-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
An Initial Analysis of the Baseline Levels of Dd-cfDNA After Pancreas Transplantation: A Prospective Study From High-volume Centers in the United States
Authors: Yoo Ashley , Riedel Alexandria , Qian Ian , Bartosic Amanda , Soltani Rudi , Kibria Gulam , Haririan Abdolreza , Drachenberg Cinthia B. , Abrams Peter L. , Odorico Jon S. , Cooper Matthew , Bromberg Jonathan S. , Scalea Joseph R. 
Published: March 2023

Background.
Pancreas transplantation offers patients with diabetes an opportunity for glucose homeostasis. Current blood tests to surveil for rejection have poor sensitivity and specificity for identifying rejection, and pancreas biopsies are challenging and associated with morbidity and graft loss. Donor-derived cell-free DNA (dd-cfDNA) is shed from transplanted organs and detectable in peripheral blood. Thus, a potential dd-cfDNA blood test assessing rejection would be clinically advantageous.

Methods.
One hundred eighty-one dd-cfDNA samples (n) were collected from 77 patients (N) up to 132 mo posttransplant.

Results.
The median dd-cfDNA level among all subjects was 0.28% (0.13%, 0.71%). In simultaneous pancreas-kidney (SPK) transplant recipients, the median dd-cfDNA level was 0.29% (0.13%, 0.71%), and it was 0.23% (0.08%, 0.71%) in pancreas transplant alone (PTA) recipients. When isolating for when without infection or rejection, the median dd-cfDNA level was 0.28% (0.13%, 0.64%) for SPK and 0.20% (0.00%, 0.32%) for PTA. Both transplant types approached 1.0% ≤1 mo posttransplant followed by a decrease in median dd-cfDNA. During episodes of rejection or infection, median dd-cfDNA levels were greater among all transplant types.

Conclusions.
The mean dd-cfDNA level for all pancreas transplant recipients is <1.0%, consistent with the published kidney transplant rejection threshold (>1.0%), regardless of SPK or PTA. Early posttransplant dd-cfDNA levels are transiently higher than later measurements. Dd-cfDNA elevation also correlates with rejection and infection and thus is a promising biomarker for surveilling pancreas transplant dysfunction.
Croceibacterium selenioxidans sp. nov., isolated from seleniferous soil
Authors: Hong Mengjuan , Luo Xiong , Fan Rongrong , An Lijin , Li Qiushi , Zhang Xiaoyan , Xu Mingzhu , Lan Yan , Shi Heli , Li Mingshun 
Published: March 2023

A Gram-negative, aerobic bacterial strain, designated LX-88T, was isolated from seleniferous soil in Enshi, Hubei Province, PR China. Strain LX-88Toxidized elemental selenium to selenite, and produced carotenoids but not bacteriochlorophyll. The isolate grew optimally at 28 °C, pH 8.0 and with 0.5 % (w/v) NaCl. Phylogenetic analysies of the organism’s 16S rRNA and bacterial core gene set sequences indicated that LX-88T belongs to the genus

Croceibacterium

, and has the highest degree of 16S rRNA gene sequence similarity to

Croceibacterium soli

MN-1T (97.4 %). The LX-88T genome was 3.4 Mbp and had a G+C content of 63.6 mol%. The average nucleotide identity and digital DNA–DNA hybridization values showed low relatedness (below 95 and 70 %, respectively) between strain LX-88T and other strains in the genus

Croceibacterium

. Ubiquinone-10 was the predominant quinone. The polar lipid profile was dominated by diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, sphingoglycolipid, an unidentified aminolipid, an unidentified phospholipid and an unidentified lipid. The major fatty acid was summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c). These physiological and biochemical tests facilitated the differentiation of strain LX-88T from other members of the genus

Croceibacterium

. The results of this multifaceted taxonomic study indicate that strain LX-88T represents a novel species in the genus

Croceibacterium

, for which the name Croceibacterium selenioxidans sp. nov. is proposed. The type strain is LX-88T (=MCCC 1K08007T=LMG 32570T).
Reproductive Experiences and Cardiovascular Disease Care in Pregnancy Capable and Post-Menopausal Individuals: Insights from the American Heart Association Research Goes Red Registry
Authors: Rao Shiavax J. , Kwapong Yaa A. , Boakye Ellen , Mallya Pratheek , Zhao Juan , Akel William , Hong Haoyun , Li Shen , Oyeka Chigolum P. , Metlock Faith Elise , Ouyang Pamela , Blumenthal Roger S. , Nasir Khurram , Khandelwal Abha , Kinzy Claire , Mehta Laxmi S. , Roger Veronique L. , Hall Jennifer L. , Sharma Garima 
Published: March 2023

AbstractBackgroundInformation on reproductive experiences and awareness of adverse pregnancy outcomes (APOs) and cardiovascular disease (CVD) risk among pregnancy-capable and post-menopausal individuals has not been well described. We sought to evaluate preconception health and APO awareness in a large population-based registry.MethodsData from the Fertility and Pregnancy Survey of the American Heart Association Research Goes Red Registry (AHA-RGR) were used. Responses to questions pertaining to prenatal health care experiences, postpartum health, and awareness of the association of APOs with CVD risk were used. We summarized responses using proportions for the overall sample and by stratifications, and we tested differences using the Chi-squared test.ResultsOf 4,651individuals in the AHA-RGR registry, 3,176 were of reproductive age, and 1,475 were postmenopausal. Among postmenopausal individuals, 37% were unaware that APOs were associated with long-term CVD risk. This varied by different racial/ethnic groups (non-Hispanic White: 38%, non-Hispanic Black: 29%, Asian: 18%, Hispanic: 41%, Other: 46%;P= 0.03). Fifty-nine percent of the participants were not educated regarding the association of APOs with long-term CVD risk by their providers. Thirty percent of the participants reported that their providers did not assess pregnancy history during current visits; this varied by race-ethnicity (P= 0.02), income (P= 0.01), and access to care (P= 0.02). Only 37.1% of the respondents were aware that CVD was the leading cause of maternal mortality.ConclusionsConsiderable knowledge gaps exist in the association of APOs with CVD risk, with disparities by race/ethnicity, and most patients are not educated on this association by their health care professionals. There is an urgent and ongoing need for more education on APOs and CVD risk, to improve the health-care experiences and postpartum health outcomes of pregnant individuals.
Neural processing of bottom up perception of biological motion under attentional load
Authors: Nizamoglu Hilal , Urgen Burcu A. 
Published: March 2023

AbstractConsidering its importance for one’s survival and social significance, biological motion (BM) perception is assumed to occur automatically. Indeed, Thornton and Vuong (2004) showed that task-irrelevant BM in the periphery interfered with task performance at the fovea. However, the neural underpinnings of this bottom-up processing of BM lacks thorough examination in the field. Under selective attention, BM perception is supported by a network of regions including the occipito-temporal, parietal, and premotor cortices. A retinotopy mapping study on BM showed distinct maps for its processing under and away from selective attention (Saygin & Sereno, 2008). Based on these findings, we investigated how bottom-up perception of BM would be processed in the human brain under attentional load when it was shown away from the focus of attention as a task-irrelevant stimulus. Participants (N=31) underwent an fMRI study in which they performed an attentionally demanding visual detection task at the fovea while intact or scrambled PLDs of BM were shown at the periphery. Our results showed the main effect of attentional load in fronto-parietal regions and the main effect of peripheral stimuli in occipito-temporal cortex. Both univariate activity maps and multivariate pattern analysis results support the attentional load modulation on BM in the occipito-temporal cortex. In conclusion, BM is processed within the motion sensitive regions in the occipito-temporal cortex even when it is away from selective attention, and is modulated by the top-down factor of attentional load.
Adolescence is characterized by more sedentary behavior and less physical activity even among highly active forager-farmers
Authors: Caldwell Ann E. , Cummings Daniel K. , Hooper Paul L. , Trumble Benjamin C. , Gurven Michael , Stiegltz Jonathan , Davis Helen E. , Kaplan Hillard 
Published: March 2023

AbstractOver 80% of adolescents worldwide are insufficiently active, posing massive public health and economic challenges. Declining physical activity (PA) and sex differences in PA consistently accompany transitions from childhood to adulthood in post-industrialized populations and are attributed to psychosocial and environmental factors. An overarching evolutionary theoretical framework and data from pre-industrialized populations are lacking. In this cross-sectional study we test a hypothesis from life history theory, that adolescent PA reductions reflect an evolved strategy to conserve energy, given the increasing sex-specific energetic demands for growth and reproductive maturation. Detailed measures of PA and pubertal maturation are assessed among Tsimane forager-farmers (age: 7-22 yrs.; 50% female, n=110). We find that 71% of Tsimane sampled meet World Health Organization PA guidelines (≥60 minutes/day of moderate-to-vigorous PA). Consistent with post-industrialized populations, we observe sex differences and inverse age-activity associations mediated by Tanner stage. Physical inactivity in adolescence is distinct from other health risk behaviors and also not merely resulting from obesogenic environments.
Taxonomic distribution of metabolic functions underpins nutrient cycling inTrichodesmiumconsortia
Authors: Koedooder Coco , Zhang Futing , Wang Siyuan , Basu Subhajit , Haley Sheean T. , Tolic Nikola , Nicora Carrie D. , del Rio Tijana Glavina , Dyhrman Sonya T. , Gledhill Martha , Boiteau Rene M. , Rubin-Blum Maxim , Shaked Yeala 
Published: March 2023

AbstractThe photosynthetic and diazotrophic cyanobacteriumTrichodesmiumis a key contributor to marine biogeochemical cycles in the subtropical-oligotrophic oceans.Trichodesmiumforms colonies that harbor a distinct microbial community, which expands their functional potential and is predicted to influence the cycling of carbon, nitrogen, phosphorus and iron (C, N, P, and Fe). To link key traits to taxa and elucidate how community structure influences nutrient cycling, we assessed Red SeaTrichodesmiumcolonies using metagenomics and metaproteomics. This diverse consortium comprises bacteria that typically associate with algae and particles, such as the ubiquitousAlteromonas macleodii,but also lineages specific toTrichodesmium, such as members from the order Balneolales. These bacteria carry functional traits that would influence resource cycling in the consortium, including siderophore biosynthesis, reduced phosphorus metabolism, vitamins, denitrification, and dissimilatory-nitrate-reduction-to-ammonium (DNRA) pathways. Denitrification and DNRA appeared to be modular as bacteria collectively completed the steps for these pathways. The vast majority of associated bacteria were auxotrophic for vitamins, indicating the interdependency of consortium members.Trichodesmiumin turn may rely on associated bacteria to meet its high Fe demand as several lineages can synthesize the photolabile siderophores vibrioferrin, rhizoferrin, and petrobactin, enhancing the bioavailability of particulate-Fe to the entire consortium. Our results highlight thatTrichodesmiumis a hotspot for C, N, P, Fe, and vitamin exchange. The functional redundancy of nutrient cycling in the consortium likely underpins its resilience within an ever-changing global environment.ImportanceColonies of the cyanobacteriaTrichodesmiumact as a biological hotspot for the usage and recycling of key resources such as C, N, P and Fe within an otherwise oligotrophic environment. WhileTrichodesmiumcolonies are known to interact with a unique community of algae and particle-associated microbes, our understanding of the taxa that populate these colonies and the gene functions they encode is still limited. Characterizing the taxa and adaptive strategies that influence consortium physiology and its concomitant biogeochemistry is critical in a future ocean predicted to have increasing particulate fluxes and resource-depleted regions.
Coxiella burnetiiactively blocks IL-17-induced oxidative stress in macrophages
Authors: Clemente Tatiana M. , Augusto Leonardo , Angara Rajendra K. , Gilk Stacey D. 
Published: March 2023

AbstractCoxiella burnetiiis a highly infectious pathogen that causes Q fever, a leading cause of culture-negative endocarditis.Coxiellafirst targets alveolar macrophages and forms a phagolysosome-like compartment called theCoxiella-ContainingVacuole (CCV). Successful host cell infection requires the Type 4B Secretion System (T4BSS), which translocates bacterial effector proteins across the CCV membrane into the host cytoplasm, where they manipulate numerous cell processes. Our prior transcriptional studies revealed thatCoxiellaT4BSS blocks IL-17 signaling in macrophages. Given that IL-17 is known to protect against pulmonary pathogens, we hypothesize thatC. burnetiiT4BSS downregulates intracellular IL-17 signaling to evade the host immune response and promote bacterial pathogenesis. Using a stable IL-17 promoter reporter cell line, we confirmed thatCoxiellaT4BSS blocks IL-17 transcription activation. Assessment of the phosphorylation state of NF-κB, MAPK, and JNK revealed thatCoxielladownregulates IL-17 activation of these proteins. Using ACT1 knockdown and IL-17RA or TRAF6 knockout cells, we next determined that IL17RA-ACT1-TRAF6 pathway is essential for the IL-17 bactericidal effect in macrophages. In addition, macrophages stimulated with IL-17 generate higher levels of reactive oxygen species, which is likely connected to the bactericidal effect of IL-17. However,C. burnetiiT4SS effector proteins block the IL-17-mediated oxidative stress, suggesting thatCoxiellablocks IL-17 signaling to avoid direct killing by the macrophages.ImportanceBacterial pathogens are constantly evolving mechanisms to modulate the hostile host environment encountered during infection.Coxiella burnetii, the causative agent of Q fever, is a fascinating example of intracellular parasitism.Coxiellasurvives in a phagolysosome-like vacuole and uses the Dot/Icm type IVB secretion system (T4BSS) to deliver bacterial effector proteins into the host cell cytoplasm to manipulate several host cell functions. We recently demonstrated thatCoxiellaT4BSS blocks the IL-17 signaling in macrophages. Here, we found thatCoxiellaT4BSS inhibits IL-17 activation of the NF-κB and MAPK pathways and blocks IL-17-mediated oxidative stress. These findings reveal a novel strategy employed by intracellular bacteria to escape the immune response during initial stages of infection. Further identification of virulence factors involved in this mechanism will bring to light new therapeutic targets to prevent Q fever development into a chronic life-threatening endocarditis.
Human resources analytics: where do we go from here?
Authors: Bahuguna Prakash Chandra , Srivastava Rajeev , Tiwari Saurabh 
Published: March 2023

PurposeHuman resource analytics (HRA) has developed as a new business trend and challenge, stressing the strategic relevance of human resource management (HRM) to senior management executives. HRA is a process that uses statistical techniques, to link HR practices to organizational performance. The purpose of this study is to carry out recent development in HRA, bibliometric analysis and content analysis to present a comprehensive account of HRA to fill the gap in the evolution and status of its research.Design/methodology/approachThe study is based on the recent advances in HRA in terms of it evolution and advancement by analyzing and drawing conclusions 480 articles retrieved from the Web of Science (WoS) database from 2003 to March 2022. The methodology is divided into four steps: data collection, analysis, visualization and interpretation. The study performed a rigorous bibliometric assessment of HRA using the bibliometric R-package and VOS viewer.FindingsThe findings based on the literature survey, and bibliometric analysis, reveal the path-breaking articles, the prominent authors, most contributing institutions and countries that have contributed to the HRA scholarship. The results show that the number of publications has significantly increased from 2015 onwards, reaching a maximum of 101 journals in 2021. The USA, China, India, Canada and the United Kingdom were the most productive countries in terms of the total number of publications. Human Resource Management Journal, Human Resource Management, International Journal of Manpower, and Journal of Organizational Effectiveness-People and Performance are the top four academic outlets in the field of HRA. Additionally, the study identifies four clusters of HRA research and the knowledge gaps in HRA scholarship.Research limitations/implicationsThe present study is based on the articles retrieved from the WoS. The study underpins HRA research to understand the trends and presents a structured account. However, the study is not free from limitations. It is recommended that future research could be undertaken by combining WoS and Scopus databases to have a more detailed and comprehensive view. This study indicates that the field is still in its infancy stage. Hence, there is a need for more arduous research on the topic to help develop a better understanding of this field.Originality/valueThe findings of knowledge clusters will drive future researchers to augment the field. The evolution of the four clusters and their subsequent development will fill the gaps in the literature. This study enriches the HRA literature and the findings of this study may assist academicians, researchers and managers in furthering their research in the identified research clusters
Developing a collection around transgender life-writing at Senate House Library, University of London
Authors: Leahy Amy 
Published: March 2023

Purpose
The purpose of this case study is to document the process of building a collection of works around transgender life-writing, following the identification of a significant gap in the existing collections.

Design/methodology/approach
This case study describes and evaluates a collection development project undertaken at Senate House Library, University of London. After evaluating four comparable case studies, guidelines were developed for acquisitions to the collection, based on subject, conservation needs and financial expense.

Findings
Twenty items were selected for the collection, dating from 1933 to 2015, including books and magazines in multiple languages. The items acquired for the collection push back against the genre’s traditional preoccupation with transition. Writers describe their experiences as a racing driver and fighter pilot (Roberta Cowell), an NGO director (A. Revathi), a Buddhist monk (Michael Dillon), a professional tennis player and ophthalmologist (Renée Richards), and a travel writer, journalist and mountaineer (Jan Morris).

Research limitations/implications
Challenges included setting the scope of the collection, and questions around the cataloguing and arrangement of materials.

Practical implications
Items acquired for the collection entered the library separately and were processed individually by the library’s cataloguing team as they arrived. Several issues arose during this stage of the project.

Social implications
To serve the needs of library users effectively, it is necessary to analyse the imbalances in collections as a routine practice.

Originality/value
The case study is original in focusing on a comparably small project with larger implications for the user experience and inclusivity of a library and its collections.