bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-grade papillary Schneiderian carcinoma with TP53 mutation: a case report and review of the literature
Authors: Yuzawa Sayaka , Michizuka Tomohiko , Kakisaka Rika , Ono Yusuke , Hayashi Manami , Takahara Miki , Katada Akihiro , Mizukami Yusuke , Tanino Mishie 
Published: April 2023

Abstract
Background
Low-grade papillary Schneiderian carcinoma (LGPSC) is a relatively new entity of the sinonasal tract and is characterized by a bland morphology simulating sinonasal papilloma, invasive growth pattern with pushing borders, and aggressive clinical behavior with multiple recurrences and metastatic potential. Recently, DEK::AFF2 fusions were identified in LGPSC. However, some LPGSCs lack DEK::AFF2 fusion, and the molecular features of these tumors have not been clarified.

Case presentation
A 69-year-old man presented with a discharge of pus from his left cheek. Computed tomography revealed a mass involving the left maxillary sinus, ethmoid sinus, and nasal cavity with the destruction of the orbital wall. The biopsy specimens showed that the tumor had a predominantly exophytic, papillary growth and did not have an apparent stromal invasion. The tumor was composed of multilayered epithelium that showed bland morphology with a round to polygonal shape, abundant eosinophilic cytoplasm, and uniform nuclei. Dense neutrophilic infiltrates were focally present. Immunohistochemically, CK5/6 was strongly and diffusely positive, and p16 was negative. p63 was mainly positive in the basal layer, and EMA was predominantly expressed in the outermost cell layer. DNA-based targeted sequencing showed TP53 R175H mutation, whereas neither EGFR nor KRAS mutation was identified. Reverse transcription polymerase chain reaction and fluorescence in situ hybridization revealed no DEK::AFF2 fusion.

Conclusions
We describe the first case of TP53-mutant LGPSC and review the literature. LGPSC is a genetically heterogeneous entity, and the recognition of this rare entity and comprehensive assessment of clinicopathological and molecular findings are crucial for the correct pathological diagnosis and clinical management.
Evaluating health information provided to kratom consumers by good manufacturing practice-qualified vendors
Authors: Hill Katherine , Gibson Stephen , Grundmann Oliver , Smith Kirsten E. , Ballard Jonathan , Stanciu Corneliu N. 
Published: April 2023

Abstract
Background
“Kratom” commonly refers to the botanical Mitragyna speciosa, native to Southeast Asia, which is increasingly used globally for its unique pharmacological effects. Motives for using the whole plant material or kratom-derived products include self-management of pain, mental health disorders, symptoms related to substance use disorders, and/or to increase energy. In the United States, kratom products have varying alkaloid content, potencies, and marketing profiles. There is little regulatory oversight over kratom, as it is currently not approved as a dietary supplement by the Food and Drug Administration. This results in substantial variability in labeling of kratom products and the product information provided to consumers.

Methods
In January 2023, we evaluated the American Kratom Association’s Good Manufacturing Practices (GMP) qualified vendors’ websites (n = 42) using the well-established and validated DISCERN instrument to examine the quality of health information provided to consumers. DISCERN contains 15 five-point Likert-scale questions on specific criteria, with the highest possible score being 75, indicating that all the DISCERN criteria have been fulfilled by the website (i.e., the highest quality information is provided to consumers).

Results
The mean DISCERN score for all evaluated online kratom vendors was 32.72 (SD = 6.69; score range 18.00–43.76). Overall, vendors scored higher on DISCERN questions assessing the website’s reliability, as vendors typically provided clear information for consumers about product availability, purchasing, shipping, etc. On average, vendors scored poorly on the DISCERN section pertaining to the quality of the health information provided. Information on kratom’s potential risks and benefits was particularly insufficient.

Conclusions
Consumers require high quality information in order to make informed decisions concerning use, which entails disclosure of known risks and potential benefits. The online kratom vendors evaluated in this study should consider enhancing the quality of health information provided, especially information regarding kratom’s risks and benefits. Further, consumers should be made aware of current knowledge gaps related to kratom’s effects. Clinicians must also be aware of the lack of evidence-based information available to their patients who use kratom or are interested in using kratom products, in order to facilitate educational discussions with them.
Levothyroxine use and longitudinal changes in thigh muscles in at-risk participants for knee osteoarthritis: preliminary analysis from Osteoarthritis Initiative cohort
Authors: Mohajer Bahram , Moradi Kamyar , Guermazi Ali , Mammen Jennifer S. R. , Hunter David J. , Roemer Frank W. , Demehri Shadpour 
Published: April 2023

Abstract
Background
We examined the association between levothyroxine use and longitudinal MRI biomarkers for thigh muscle mass and composition in at-risk participants for knee osteoarthritis (KOA) and their mediatory role in subsequent KOA incidence.

Methods
Using the Osteoarthritis Initiative (OAI) data, we included the thighs and corresponding knees of participants at risk but without established radiographic KOA (baseline Kellgren-Lawrence grade (KL) < 2). Levothyroxine users were defined as self-reported use at all annual follow-up visits until the 4th year and were matched with levothyroxine non-users for potential confounders (KOA risk factors, comorbidities, and relevant medications covariates) using 1:2/3 propensity score (PS) matching. Using a previously developed and validated deep learning method for thigh segmentation, we assessed the association between levothyroxine use and 4-year longitudinal changes in muscle mass, including cross-sectional area (CSA) and muscle composition biomarkers including intra-MAT (within-muscle fat), contractile percentage (non-fat muscle CSA/total muscle CSA), and specific force (force per CSA). We further assessed whether levothyroxine use is associated with an 8-year risk of standard KOA radiographic (KL ≥ 2) and symptomatic incidence (incidence of radiographic KOA and pain on most of the days in the past 12 months). Finally, using a mediation analysis, we assessed whether the association between levothyroxine use and KOA incidence is mediated via muscle changes.

Results
We included 1043 matched thighs/knees (266:777 levothyroxine users:non-users; average ± SD age: 61 ± 9 years, female/male: 4). Levothyroxine use was associated with decreased quadriceps CSAs (mean difference, 95%CI: − 16.06 mm2/year, − 26.70 to − 5.41) but not thigh muscles’ composition (e.g., intra-MAT). Levothyroxine use was also associated with an increased 8-year risk of radiographic (hazard ratio (HR), 95%CI: 1.78, 1.15–2.75) and symptomatic KOA incidence (HR, 95%CI: 1.93, 1.19–3.13). Mediation analysis showed that a decrease in quadriceps mass (i.e., CSA) partially mediated the increased risk of KOA incidence associated with levothyroxine use.

Conclusions
Our exploratory analyses suggest that levothyroxine use may be associated with loss of quadriceps muscle mass, which may also partially mediate the increased risk of subsequent KOA incidence. Study interpretation should consider underlying thyroid function as a potential confounder or effect modifier. Therefore, future studies are warranted to investigate the underlying thyroid function biomarkers for longitudinal changes in the thigh muscles.
Baseline structural MRI and plasma biomarkers predict longitudinal structural atrophy and cognitive decline in early Alzheimer’s disease
Authors: Xie Long , Das Sandhitsu R. , Wisse Laura E. M. , Ittyerah Ranjit , de Flores Robin , Shaw Leslie M. , Yushkevich Paul A. , Wolk David A. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: April 2023

Abstract
Background
Crucial to the success of clinical trials targeting early Alzheimer’s disease (AD) is recruiting participants who are more likely to progress over the course of the trials. We hypothesize that a combination of plasma and structural MRI biomarkers, which are less costly and non-invasive, is predictive of longitudinal progression measured by atrophy and cognitive decline in early AD, providing a practical alternative to PET or cerebrospinal fluid biomarkers.

Methods
Longitudinal T1-weighted MRI, cognitive (memory-related test scores and clinical dementia rating scale), and plasma measurements of 245 cognitively normal (CN) and 361 mild cognitive impairment (MCI) patients from ADNI were included. Subjects were further divided into β-amyloid positive/negative (Aβ+/Aβ−)] subgroups. Baseline plasma (p-tau181 and neurofilament light chain) and MRI-based structural medial temporal lobe subregional measurements and their association with longitudinal measures of atrophy and cognitive decline were tested using stepwise linear mixed effect modeling in CN and MCI, as well as separately in the Aβ+/Aβ− subgroups. Receiver operating characteristic (ROC) analyses were performed to investigate the discriminative power of each model in separating fast and slow progressors (first and last terciles) of each longitudinal measurement.

Results
A total of 245 CN (35.0% Aβ+) and 361 MCI (53.2% Aβ+) participants were included. In the CN and MCI groups, both baseline plasma and structural MRI biomarkers were included in most models. These relationships were maintained when limited to the Aβ+ and Aβ− subgroups, including Aβ− CN (normal aging). ROC analyses demonstrated reliable discriminative power in identifying fast from slow progressors in MCI [area under the curve (AUC): 0.78–0.93] and more modestly in CN (0.65–0.73).

Conclusions
The present data support the notion that plasma and MRI biomarkers, which are relatively easy to obtain, provide a prediction for the rate of future cognitive and neurodegenerative progression that may be particularly useful in clinical trial stratification and prognosis. Additionally, the effect in Aβ− CN indicates the potential use of these biomarkers in predicting a normal age-related decline.
Implementation of structured reporting in clinical routine: a review of 7 years of institutional experience
Authors: Jorg Tobias , Halfmann Moritz C. , Arnhold Gordon , Pinto dos Santos Daniel , Kloeckner Roman , Düber Christoph , Mildenberger Peter , Jungmann Florian , Müller Lukas 
Published: April 2023

Abstract
Background
To evaluate the implementation process of structured reporting (SR) in a tertiary care institution over a period of 7 years.

Methods
We analysed the content of our image database from January 2016 to December 2022 and compared the numbers of structured reports and free-text reports. For the ten most common SR templates, usage proportions were calculated on a quarterly basis. Annual modality-specific SR usage was calculated for ultrasound, CT, and MRI. During the implementation process, we surveyed radiologists and clinical referring physicians concerning their views on reporting in radiology.

Results
As of December 2022, our reporting platform contained more than 22,000 structured reports. Use of the ten most common SR templates increased markedly since their implementation, leading to a mean SR usage of 77% in Q4 2022. The highest percentages of SR usage were shown for trauma CT, focussed assessment with ultrasound for trauma (FAST), and prostate MRI: 97%, 95%, and 92%, respectively, in 2022. Overall modality-specific SR usage was 17% for ultrasound, 13% for CT, and 6% for MRI in 2022. Both radiologists and referring physicians were more satisfied with structured reports and rated SR better than free-text reporting (FTR) on various attributes.

Conclusions
The increasing SR usage during the period under review and the positive attitude towards SR among both radiologists and clinical referrers show that SR can be successfully implemented. We therefore encourage others to take this step in order to benefit from the advantages of SR.

Key points

Structured reporting usage increased markedly since its implementation at our institution in 2016.

Mean usage for the ten most popular structured reporting templates was 77% in 2022.

Both radiologists and referring physicians preferred structured reports over free-text reports.

Our data shows that structured reporting can be successfully implemented.

We strongly encourage others to implement structured reporting at their institutions.
Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases
Authors: Zhu Xueqing , Ma Dan , Yang Baoqi , An Qi , Zhao Jingwen , Gao Xinnan , Zhang Liyun 
Published: April 2023

AbstractAutoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad.
Characterization of an unusual coating on funerary portraits from Roman Egypt circa 100-300AD
Authors: Kirby Daniel P. , Svoboda Marie , Mazurek Joy , Spaabæk Lin Rosa , Southon John 
Published: April 2023

Abstract
This paper details the investigation of a discrete coating observed on a group of Egyptian panel paintings, six mummy portraits and one funerary panel, dating from first-third century CE. Six mummy portraits in this group are encaustic, and the funerary panel is tempera using an animal glue binder. An accretion or coating has been observed on the surface and recesses of the paint layers on these panels. Examination of the portraits using ultraviolet radiation revealed an irregular visible fluorescence on the surface. On the mummy portraits, the fluorescence often extends only as far as where the linen wrappings would have secured the portrait to its mummy. Under magnification, the coating appears as a crizzled encrustation. Material exhibiting these characteristics was sampled from the surface of all seven panels. Initial analysis of samples from four panels by gas chromatography mass spectrometry (GC/MS) and enzyme-linked immunoassay (ELISA) revealed the presence of egg. Subsequent analysis of the coating from all seven portraits by peptide mass fingerprinting (PMF) and liquid chromatography with tandem mass spectrometry (LCMSMS) confirmed egg and further characterized the coating as highly deamidated, whole hen egg, or hen egg white in one instance. Importantly, the 14C date of the coating from two portraits indicates the time of application as approximately 2000 years ago, implying that the coating, at least in those cases, is not a modern addition. This report summarizes the examination and analytical characterization of this unusual coating. Possibly applied as an aesthetic or protective layer, or a symbolic and ritual unguent, the principal function of this coating remains unknown.
Interest rates and real estate prices: a panel study
Authors: Vonlanthen Joël 
Published: April 2023

AbstractThis study examines the connection between interest rates and real estate prices in Switzerland. In considering median prices of six real estate groups consisting of rental apartments, owner-occupied flats, houses, office space, industrial real estate and sales area between the first quarter of 2005 and the fourth quarter of 2018 across 106 Swiss regions, we studied their connection with four interest rate proxies: yields on governmental bonds with 10-year maturity, fixed mortgage rates with 10-year maturity, variable mortgage rates and a newly introduced variable indicating the spread between net initial returns and yields on governmental bonds. Not only do our results show how real estate groups react to specific interest rate representatives, but also how this effect varies between Swiss regions.
The determinants of reliable smart grid from experts’ perspective
Authors: Mashal Ibrahim , Khashan Osama A. , Hijjawi Mohammad , Alshinwan Mohammad 
Published: April 2023

AbstractA smart grid integrates communication networks with the conventional electrical grid. Due to their potential, smart grids are anticipated to achieve widespread deployment. A key component of the success and adoption of smart grids is reliability. Without knowing users’ impressions of the reliability of the smart grid, users will not easily accept and participate in it or its services. However, very few studies address smart grid reliability from the perspective of users. Thus, there is a urgent need to identify key factors that affect smart grid reliability from the user’s viewpoint. The goal of this paper is to examine user perceptions of smart grid reliability and assess their success factors in an effort to close the gap in the literature. This paper propose a model to investigate and determine the most crucial factors that affect the smart grid's reliability based on the Multiple-criteria decision-making (MCDM) method. Firstly, a comprehensive literature analysis was conducted to determine the criteria and sub-criteria used to construct the model; then, the model is constructed using fifteen sub-criteria covering big data, network systems, and grid efficiency criteria; finally, the Fuzzy Analytic Hierarchy Approach (FAHP) and fuzzy triangular numbers are used to evaluate and prioritize the criteria. Twenty smart grid experts were consulted to collect data. The results indicate the significance of the ‘Big Data’ criterion, closely followed by ‘Grid Efficiency’ criterion. Additionally, it is discovered that the sub-criteria of ‘Privacy’ and ‘Interoperability’ had a significant impact on the reliability of the smart grid. The sensitivity analysis shows the variation of factors ranking and the stability and robustness of the model and the results. The research presented in this study has practical applications for academics, engineers, decision-makers, and stakeholders.
External Validation of a Prognostic Model of Overall Survival in Men With Chemotherapy-Naïve Metastatic Castration-Resistant Prostate Cancer
Authors: Halabi Susan , Yang Qian , Roy Akash , Luo Bin , Araujo John C. , Logothetis Christopher , Sternberg Cora N. , Armstrong Andrew J. , Carducci Michael A. , Chi Kim N. , de Bono Johann S. , Petrylak Daniel P. , Fizazi Karim , Higano Celestia S. , Morris Michael J. , Rathkopf Dana E. , Saad Fred , Ryan Charles J. , Small Eric J. , Kelly William Kevin 
Published: April 2023

PURPOSEWe have previously developed and externally validated a prognostic model of overall survival (OS) in men with metastatic, castration-resistant prostate cancer (mCRPC) treated with docetaxel. We sought to externally validate this model in a broader group of men with docetaxel-naïve mCRPC and in specific subgroups (White, Black, Asian patients, different age groups, and specific treatments) and to classify patients into validated two and three prognostic risk groupings on the basis of the model.METHODSData from 8,083 docetaxel-naïve mCRPC men randomly assigned on seven phase III trials were used to validate the prognostic model of OS. We assessed the predictive performance of the model by computing the time-dependent area under the receiver operating characteristic curve (tAUC) and validated the two-risk (low and high) and three-risk prognostic groups (low, intermediate, and high).RESULTSThe tAUC was 0.74 (95% CI, 0.73 to 0.75), and when adjusting for the first-line androgen receptor (AR) inhibitor trial status, the tAUC was 0.75 (95% CI, 0.74 to 0.76). Similar results were observed by the different racial, age, and treatment subgroups. In patients enrolled on first-line AR inhibitor trials, the median OS (months) in the low-, intermediate-, and high-prognostic risk groups were 43.3 (95% CI, 40.7 to 45.8), 27.7 (95% CI, 25.8 to 31.3), and 15.4 (95% CI, 14.0 to 17.9), respectively. Compared with the low-risk prognostic group, the hazard ratios for the high- and intermediate-risk groups were 4.3 (95% CI, 3.6 to 5.1; P < .0001) and 1.9 (95% CI, 1.7 to 2.1; P < .0001).CONCLUSIONThis prognostic model for OS in docetaxel-naïve men with mCRPC has been validated using data from seven trials and yields similar results overall and across race, age, and different treatment classes. The prognostic risk groups are robust and can be used to identify groups of patients for enrichment designs and for stratification in randomized clinical trials.[Media: see text]
Chrischonakirche von Bettingen
Authors: Moosbrugger-Leu Rudolf 
Published: April 2023

In einem ersten Teil beschreibt der Autor ein frühmittelalterliches Plattengrab aus den Jahrzehnten um 700, das möglicherweise den Anfang dieser christlichen Kultstätte bildete. Ausführlich geht er auf die Legende um die heilige Chrischona sowie das Patrozinium des heiligen Brictius ein, der als Beschützer der Kinder gilt und zu dem er den Friedhof der Kleinkinder im Osten der Kirche in Verbindung bringt.
Den Hauptteil bilden die archäologischen und baugeschichtlichen Befunde. Sie bezeugen eine frühmittelalterliche Anlage, einen romanischen sowie hoch- bis spätgotischen Bau.
In einem dritten Teil werden besondere Kleinfunde vorgelegt. So werden u.a. Werkstücke und Halbfabrikate beschrieben, die über die Herstellung von Beinknöpfen durch den ersten Chrischona-Bruder (Anf. 19. Jh.) berichten. Bei den Fundmünzen handelt es sich vor allem um Opfergaben, die im Mittelalter ins Heiligengrab kamen.