bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementing a nurse-delivered cognitive behavioural therapy intervention to reduce the impact of hot flushes/night sweats in women with breast cancer: A qualitative process evaluation of the MENOS4 trial
Authors: Boxall Cherish , Fenlon Deborah , May Carl , Nuttall Jacqui , Hunter Myra S. 
Published: January 2023

Abstract
Background: Hot flushes and night sweats are life-altering symptoms experienced by many women after breast cancer treatment. A randomised controlled trial (RCT) was conducted to explore the effectiveness of breast care nurse (BCN)-led group cognitive behavioural therapy (CBT). This paper reported findings from a qualitative process evaluation to optimise the CBT intervention and explore the determinants of implementation into routine practice.
Methods: Qualitative process evaluation occurred in parallel with the RCT to explore patient and healthcare staff experiences and perspectives using semi-structured interviews pre-and post-intervention. Normalisation Process Theory (NPT) informed data collection, analysis, and reporting of findings. The analysis involved inductive thematic analysis, NPT coding manual and subsequent mapping onto NPT constructs.
Results: BCNs (n=8), managers (n=2), surgeons (n=3) and trial participants (n=8) from six sites took part. All stakeholders believed group CBT met a need for non-medical hot flushes/night sweats treatment, however, had little exposure or understanding of CBT before MENOS4. BCNs believed the work fitted with their identity and felt confident in delivering the sessions. Despite little understanding, patients enrolled onto group CBT because the BCNs were trusted to have the knowledge and understanding to support their needs and despite initial scepticism, reported great benefit from group-based participation. Both managers and surgeons were keen for BCNs to take responsibility for all aspects of CBT delivery, but there were some tensions with existing clinical commitments.
Conclusions: Both healthcare staff and patient participants believe BCN-led group CBT is a beneficial service but barriers to long-term implementation into routine care suggest there needs to be multi-level organisational support.
Trial registration: NCT02623374 – Last updated 07/12/2015 on ClinicalTrials.gov PRS
CENP-E activation by Aurora A and B controls kinetochore fibrous corona disassembly
Authors: Eibes Susana , Rajendraprasad Girish , Guasch-Boldu Claudia , Kubat Mirela , Steblyanko Yulia , Barisic Marin 
Published: January 2023

Abstract
Accurate chromosome segregation in mitosis depends on multiprotein structures called kinetochores (KTs) that are built on the centromeric region of sister chromatids and serve to capture mitotic spindle microtubules (MTs). In early mitosis, unattached KTs expand a crescent-shaped structure called fibrous corona whose function is to facilitate initial KT-MT attachments and chromosome transport by MTs. Subsequently, the fibrous corona must be timely disassembled to prevent segregation errors. Although recent studies provided new insights on the molecular content and mechanism of fibrous corona assembly, it remains unknown what triggers the disassembly of the outermost and dynamic layer of the KT. Here, we show that Aurora A and B kinases (AurA and AurB) phosphorylate CENP-E to release it from an autoinhibited state. At KTs, AurB phosphorylates CENP-E to prevent its premature removal together with other corona proteins by dynein. At the spindle poles, AurA phosphorylates CENP-E to promote chromosome congression and prevent accumulation of corona proteins at the centrosomes, allowing for their intracellular redistribution. Thus, the AurA/B-CENP-E axis establishes the long-sought mechanism of fibrous corona disassembly that is essential for accurate chromosome segregation.
WITHDRAWN: Linking public perspectives on watershed issues to indicators, and natural regions as management units within a large watershed
Authors: Montemayor Marilou B. 
Published: January 2023

Abstract
Public consultation workshops were held at three locations that corresponded to natural regions (ecological units) within the Red Deer River watershed (hydrologic unit), Alberta, Canada. Participants were asked what their watershed issues were. Issues were linked to watershed indicators used in the completed state of the watershed report (SOW) that would eventually be used in the future watershed management plan (WMP). Issues gathered were sorted, counted, averages calculated and ranked, and comparisons made between locations. Two main categories of issues emerged: environmental and socio-economic. There were nine environmental indicators, three of which were new, and a whole new set of eight socio-economic watershed indicators. Natural regions influenced environmental indicators and to a lesser degree, socio-economic indicators. Dividing the large watershed (4,965,000 ha) using natural regions as management units could serve as “common-places” for their respective local communities and governments, an adaptation of the place-based approach. Ranking of environmental indicators could be used for developing a WMP in phases. This study illustrates the importance of public consultations, the consideration of both ecological and hydrologic management units, and both environmental and socio-economic indicators, in watershed management planning.
Age-dependent blood signatures of rehabilitated patients with mild COVID-19
Authors: Guo Xuantong , Liu Xiaoxiong , Tang Jiahang , Deng Chunshan , Jiang Wanli , Qiao Bin , Wang Ruoxi , Chen Zuxin , Wang Yanchun , Liu Xin-an 
Published: January 2023

Abstract
Growing evidence suggests that pulmonary and neurological sequelae from critical novel coronavirus disease 2019 (COVID-19) can occur which are closely related to immune responses. However, data on the long-term systemic biochemical sequelae in mild COVID-19 are lacking. Here we investigated the blood biochemical indexes and cytokines of 25 mild cases from Wuhan nine months after infection with COVID-19. Compared with control, rehabilitated patients with mild COVID-19 showed significant reduction in the levels of RBC count and ALB in an age-dependent manner. Major symptoms such as fatigue and memory decline were found in elderly rehabilitators. Besides the overall reduction in the correlations among hematologic indicators in rehabilitated patients, the serum cytokine assay also confirmed the age-related alterations such as the level of CD40 Ligand in rehabilitators with mild COVID-19. Our current data indicated the age-dependent long-term consequences after mild COVID-19 infection and continuous follow-up is warranted.
Is it possible to flatten-the-curve after the initial outbreak of Covid-19? A data-driven modeling analysis for Omicron pandemic in China
Authors: Liu Miao , SUN Jiaqi , LI Yusi , Shao Ning-Yi 
Published: January 2023

Abstract

In the current coronavirus disease 2019 (COVID-19) pandemic, the Omicron variant of severe acute respiratory syndrome coronavirus 2 has become the predominant strain circulating worldwide. In China, enormous controversies exist regarding the “dynamic zero tolerance” (DZT) and “totally no inventions” (TNI) strategies for preventing the spread of the Omicron variant. Currently, China is gradually relaxing the COVID-19 measures from DZT level. In such situations, the “flatten-the-curve” (FTC) strategy, which decreases and maintains the low rate of infection to avoid overwhelming the healthcare system by adopting relaxed nonpharmaceutical interventions (NPIs) after the initial outbreak, has been perceived as most appropriate and effective method to prevent the spread of the Omicron variant. Hence, we established a data-driven model of Omicron transmission based on the pandemic data of Macau, Hong Kong, and Singapore in 2022 to deduce the overall prevention effect throughout China. In the current immunity level without any NPI applied, more than 12.7 billion (including asymptomatic individuals) were infected with the Omicron variant within 90 days, but the daily new infections sharply declined; moreover, Omicron outbreak would result to 1.49 million deaths within 180 days. The application of FTC could decrease the deaths by 36.91% within 360 days. Age-stratified analyses showed that the NPI application among individuals aged > 60 years would also result in 0.81 million deaths within 360 days, and the application of FTC strategy through treatment with anti-COVID drugs can reduce the number of deaths to 0.40 million. In a model of completed vaccination, the application of TNI strategy would also result in 0.56 million deaths and slightly decrease the infection numbers. The strict implementation of FTC policy combined with completed vaccination and drug use, which only resulted in 0.19 million deaths in an age-stratified model, will help end the pandemic within about 240 days. The pandemic would be terminated within a shorter period of time without resulting in a high fatality rate; therefore, the FTC policy could be strictly implemented through enhancement of immunity and drug use.
Risk factor analysis for radiographic para-aortic lymph nodes metastasis in left-sided colorectal cancer：a retrospective study
Authors: Chen Qiang , Yang Jiabin , Peng Wei , Cheng Ming , Wu Yongyou 
Published: January 2023

Abstract
Background
Synchronous para-aortic lymph node (PALN) metastasis from colorectal cancer (CRC) is rare, and the positive predictive value of pre-operative CT was low. This study aimed to clarify risk factors radiographic PALN metastasis in left-sided CRC for improving the accuracy of pre-operative CT scan.
Patients and Methods:
Patients with pathologically and radiographically confirmed diagnosis of left-sided CRC were enrolled between January 2019 and August 2021. The Correlations between clinicopathologic data and radiographic PALN metastasis were analyzed chi-squared test or Fisher exact test and the multivariate binary logistic regression model was used for multivariate analyses.
Results
There were 15(3.56%) patients with radiographic PALN metastasis. The hepatic (P = 0.023) and inferior mesenteric lymph nodes (IMLN) (P < 0.001) metastases, elevated serum carcinoembryonic antigen (CEA) (P = 0.007) and carbohydrate antigen19-9 (CA19-9) (P = 0.021) levels, longer tumor length (P = 0.003), lower degree of tumor differentiation (P < 0.001), deeper tumor invasion (P = 0.038), later lymph node staging (P < 0.001), perineural invasion (P = 0.009) and lymphovascular involvement (P < 0.001) were the risk factors for radiographic PALN metastasis. Among them, the radiographic IMLN metastasis (P = 0.003, OR = 20.927, 95% CI 2.823–155.820) was the only independent risk factor.
Conclusion
Some clinicopathologic characteristics, especially IMLN metastasis, are the risk factors for PALN metastasis.
Evolution of the incidence of COVID-19 during the first five waves in residents and professionals of nursing homes in Normandy, France
Authors: THIBON PASCAL , GRENIER Carine , EROUART Stéphane , BORGEY France , HELLO Simon LE , MARTEL Mélanie 
Published: January 2023

Abstract
Background
Older adults living in nursing homes (NH) paid a heavy price to the COVID-19 pandemic, despite early and often drastic prevention measures.
Aims
To study the characteristics and the impact of the pandemic on NH residents and professionals over 2 years.
Methods
Cross sectional study of COVID-19 clusters among residents and/or professionals in NH, from March 2020 to February 2022, in Normandy, France. We used data from the French mandatory reporting system, and cross-correlation analysis.
Results
The weekly proportion of NH with clusters was strongly correlated with population incidence (r > 0.70). Attack rates among residents and professionals were significantly lower in period 2 (vaccination rate in residents ≥50%) compared with periods 1 (waves 1 and 2) and 3 (Omicron variant ≥50%). Among residents, mortality and case fatality rates decreased drastically during periods 2 and 3.
Conclusions
Our study provides figures on the evolution of the pandemic in NH.
Natural statistics of human head orientation constrain models of vestibular processing
Authors: Sinnott Christian , Hausamann Peter , MacNeilage Paul R. 
Published: January 2023

Abstract
Head orientation relative to gravity determines how gravity-dependent environmental structure is sampled by the visual system, as well as how gravity itself is sampled by the vestibular system. Therefore, both visual and vestibular sensory processing should be shaped by the statistics of head orientation relative to gravity. Here we report the statistics of human head orientation during unconstrained natural activities in humans for the first time, and we explore implications for models of vestibular processing. We find that the distribution of head pitch is more variable than head roll and that the head pitch distribution is asymmetrical with an over-representation of downward head pitch, consistent with ground-looking behavior. We further show that pitch and roll distributions can be used as empirical priors in a Bayesian framework to explain previously measured biases in perception of both roll and pitch. We also analyze the dynamics of human head orientation to better understand how gravitational and inertial acceleration are processed by the vestibular system. Gravitational acceleration dominates at low frequencies and inertial acceleration dominates at higher frequencies. The change in relative power of gravitational and inertial components as a function of frequency places empirical constraints on dynamic models of vestibular processing. We conclude with a discussion of methodological considerations and scientific and applied domains that will benefit from continued measurement and analysis of natural head movements moving forward.
Influence of an inclined magnetic field and heat and mass transfer on the peristaltic flow of blood in an asymmetric channel
Authors: Abdelhafez M. A. , Abd-Alla A. M. , Abo-Dahab S. M. , Elmhedy Yasmine 
Published: January 2023

Abstract
This article presents a theoretical study on heat and mass transfer analysis of the peristaltic flow of blood conveying through an asymmetric channel in the presence of inclined to the magnetic field. The effects of ratio of relaxation to retardation times, non-uniform parameter, the non-dimensional amplitude, Hartman number and phase difference have been taken into account. The governing coupled non-linear partial differential equations representing the flow model are transmuted into linear ones by assuming that the wave is very long with a small Reynolds number. The converted mathematical formulations are solved analytically via the Mathematica software. Analytical expressions for the dimensionless velocity profiles of fluid, temperature, concentration, pressure gradient, increase in pressure, heat transfer coefficient and shear stress of the blood are derived. The velocity, temperature, concentration, pressure gradient, increase in pressure, heat transfer coefficient and shear stress were calculated numerically for different values of the parameters, which were represented graphically and find their physical meaning
Overexpression of MiR-32 in Chinese Hamster Ovary Cells Increases Production of Fc-fusion Protein
Authors: Bazaz Masoume , Adeli Ahmad , Azizi Mohammad , Karimipoor Morteza , Mahboudi Freidoun , Davoudi Noushin 
Published: January 2023

Abstract
The demand for industrial genetically modified host cells has been increased with the growth of the biopharmaceutical market. Numerous studies on improving host cell productivity have shown that altering host cell growth and viability through genetic engineering can increase recombinant protein production. During the last decades, it has been demonstrated that overexpression or downregulation of some microRNAs in Chinese Hamster Ovary (CHO) cells as the most often employed host cell in biopharmaceutical manufacturing, can improve their productivity. MicroRNAs are small non-coding RNAs that play a key role in controlling cellular mechanisms through their binding to different mRNA targets and negatively regulating gene expression. In efforts to increase the host cell's productivity through microRNA engineering of the cells, some microRNA targets have been selected based on their previously identified role in human cancers. MicroRNA-32 (miR-32), which is conserved between humans and hamsters (Crisetulus griseus), has been shown to play a role in the regulation of cell proliferation and apoptosis in some human cancers. In this study, we investigated the effect of miR-32 overexpression on the productivity of CHO-VEGF-trap cells. Our results indicated that stable overexpression of miR-32 could dramatically increase the productivity of CHO cells by 1.8-fold. It also significantly increases cell viability, batch culture longevity, and cell growth. To achieve these results, following the construction of a single clone producing an Fc-fusion protein, we transfected cells with a pLexJRed-miR-32 plasmid to stably produce the microRNA and evaluate the impact of mir-32 overexcretion on cell productivity, growth and viability in compare with scrambled control. Our findings highlight the application of miRNAs as CHO cell engineering tools and indicated that miR-32 could be a target for engineering CHO cells to increase cell productivity.
New agricultural wheat frontier in Brazil: Envirotypes applied in the adaptability and stability of wheat genotypes in contrasting environments
Authors: Casagrande Cleiton Renato , Mezzomo Henrique Caletti , Santos Crislene Vieira dos , Sousa Diana Jhulia Palheta se , Yamanaka Celso Hideto , Olivoto Tiago , Dias Kaio Olimpio das Graças , Borém Aluizio , Nardino Maicon 
Published: January 2023

Abstract
Global climate changes can dramatically impact wheat production in Brazil's Cerrado biome, considered a new wheat farming frontier. Therefore, new approaches are needed to better understand the G×E interaction in environments with high climate variations. Here, we integrate envirotyping, adaptability, and stability techniques to better understand the G×E interaction and provide new insights for the recommendation of tropical wheat genotypes that can perform well in hotter and drier environments. Thirty-six wheat genotypes were evaluated for grain yield in eight field trials in 2018, 2019, and 2020 in the Brazilian Cerrado region. There is strong evidence that even in irrigated conditions, temperatures > 30 ºC during the booting and heading/flowering stages dramatically reduce the grain yield. Two lines, VI14774 (GY = 3800 kg ha-1), and VI14980 (GY = 4093 kg ha-1) had better performance in the hotter environment (~ 22% and ~ 32% higher than the grand mean) and are potential germplasm sources for warmer environments at the boosting and heading/flowering stages. Overall, this study provides new insights on how the environment typing can be useful to better understand the genotype-by-environment interaction and help to breed new climate-resilient wheat cultivars for the cerrado region. In this study, the REML/BLUP and GGE Biplot methods highly correlate in terms of genotype classification for selection and recommendation purposes. The genotypes VI 14127, VI 14197, VI 14026, and BRS 264 are the closest to a hypothetical ideal genotype.
Effect of Whatsapp Based Good Enough Sex Consultation on Infertility Stress and Sexual Satisfaction in Iranian Women Who Applied for Infertility Treatment: A Randomized Control Trial
Authors: Moghaddam-tabrizi Fatemeh , Emdadi-Babanazar shahla , Haghighi Mahmonir , gharaaghaji rasool 
Published: January 2023

Abstract
Background

Infertility is associated with the reduction of sexual activity and always there is a relationship between infertility and sexual dysfunction. Infertility stress refers to a group of symptoms that appear following infertility diagnosis; these symptoms are similar to those of post-traumatic stress disorder and are specifically evident in the beliefs and feelings associated with infertility. The present study aimed to determine the effect of whatsapp based good enough sex consultation on infertility stress and sexual satisfaction in infertile women who applied for infertility treatment in a randomized control trial.

Methods

This is a double-blinded, randomized controlled trial in which a total of 100 infertile women were recruited using convenience sampling and then randomly assigned to two groups of whatsapp based GES model consultation and routine care. Data collection tools consisted of a demographic, the Larson's Sexual Satisfaction and Newton Infertility Stress questionnairs. In the pretest stage, participants in both groups completed the above questionnaires before the intervention. Participants in the intervention group were given access to the 6-week GES model consultation program. The program consisted of six consultation and assignments packages, regarding all 12 dimensions of GES model. Then participants re-completed questionnaires immediately and one month after the intervention. Data were analyzed with SPSS software version 20 using chi-squared test, independent-samples t-test, and repeated measures Analysis of Variance. The significance level (p-value) was considered to be less than 0.05.

Results

The results of rANOVA indicated that there was a significant difference in the mean scores of sexual satisfaction (with its all dimensions: desire to have sex, sexual adjustment, quality of sexual life, sexual attitude) and infertility stress (and it's all dimensions: social concern, sexual concern, relationship concern, need for parenthood, life without children) between the two groups from pre- to post-intervention, and then over the one month follow-up period in the intervention group, while scores of control participants did not show this pattern during the study (p ˂ 0.001). Considering the partial Eta squared, the effect of intervention had the highest interaction effect on both variables of sexual satisfaction (η2 = 0.52) and infertility stress (η2 = 0.82).

Conclusions

Since whatsapp based GES sex model intervention had significant effect on infertility stress and sexual satisfaction. Therefore, it is recommended to be considered as one of the practical plans in the process of treatment and counseling of infertility.
Trial registration number: IRCT20210926052593N1,
The date of registration: 13-10-2021.
Recognition of citrus fruit and planning the robotic picking sequence in orchards
Authors: Li Chunmao , Liu Fang , Fang Bin , Lu Hui , Sun Yue 
Published: January 2023

Abstract
To improve the operational efficiency of and to prevent possible collision damage in the picking of citruses by robots in densely planted complex orchards, this study proposes an algorithm based on YOLOv5 for recognizing citruses and planning a picking sequence. First, the convolutional block attention module (CBAM) is embedded into YOLOv5 to improve the feature extraction capability of the network and mitigate missed detection of occluded targets and small targets. Simultaneously, the bounding loss function is optimized to improve the positioning accuracy of the bounding box. This combined model is used to recognize and localize citruses. Then, a three-dimensional model of citrus fruit was established, and an adaptive pheromone concentration updating mechanism was introduced on the basis of the ant colony algorithm to dynamically judge the picking order of citruses and determine the optimal picking sequence. We show the quantitative and qualitative results of our method in comparison to previous methods. In tests, the F1-score of this method for citrus in a densely planted environment was 92.41%, which is a 2.81% improvement compared to YOLOv5. Compared to stochastic planning, the proposed method can plan the picking sequence of citruses in the field of view in advance and shorten the picking path. In addition, extensive sequence planning experiments on other fruits validate the superior of the proposed method. Therefore, the method in this paper may provide new solutions for citrus anti-collision picking and orchard yield forecasting and new ideas for the intelligent fruit industry.