bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Design of N‐Doped Carbon‐Coated Cobalt Nanoparticles for Highly Efficient and Durable Photothermal CO2 Conversion
Authors: Ma Jun , Yu Jing , Chen Guangyu , Bai Yu , Liu Shengkun , Hu Yangguang , Al‐Mamun Mohammad , Wang Yu , Gong Wanbing , Liu Dong , Li Yafei , Long Ran , Zhao Huijun , Xiong Yujie 
Published: July 2023

AbstractPhotothermal CO2 hydrogenation to high‐value‐added chemicals and fuels is an appealing approach to alleviate energy and environmental concerns. However, it still relies on the development of earth‐abundant, efficient, and durable catalysts. Here, the design of N‐doped carbon‐coated Co nanoparticles (NPs), as a photothermal catalyst, synthesized through a two‐step pyrolysis of Co‐based ZIF‐67 precursor, is reported. Consequently, the catalyst exhibits remarkable activity and stability for photothermal CO2 hydrogenation to CO with a 0.75 mol gcat−1 h−1 CO production rate under the full spectrum of light illumination. The high activity and durability of these Co NPs are mainly attributed to the synergy of the attuned size of Co NPs, the thickness of carbon layers, and the N doping species. Impressively, the experimental characterizations and theoretical simulations show that such a simple N‐doped carbon coating strategy can effectively facilitate the desorption of generated CO and activation of reactants due to the strong photothermal effect. This work provides a simple and efficient route for the preparation of highly active and durable nonprecious metal catalysts for promising photothermal catalytic reactions.
Versatile Protein and Its Subunit Biomolecules for Advanced Rechargeable Batteries
Authors: Wu Yulun , Li Huangxu , Liu Tiancheng , Xu Ming 
Published: July 2023

AbstractRechargeable batteries are of great significance for alleviating the growing energy crisis by providing efficient and sustainable energy storage solutions. However, the multiple issues associated with the diverse components in a battery system as well as the interphase problems greatly hinder their applications. Proteins and their subunits, peptides, and amino acids, are versatile biomolecules. Functional groups in different amino acids endow these biomolecules with unique properties including self‐assembly, ion‐conducting, antioxidation, great affinity to exterior species, etc. Besides, protein and its subunit materials can not only work in solid forms but also in liquid forms when dissolved in solutions, making them more versatile to realize materials engineering via diverse approaches. In this review, it is aimed to offer a comprehensive understanding of the properties of proteins and their subunits, and research progress of using these versatile biomolecules to address the engineering issues of various rechargeable batteries, including alkali‐ion batteries, lithium–sulfur batteries, metal–air batteries, and flow batteries. The state‐of‐the‐art advances in electrode, electrolyte, separator, binder, catalyst, interphase modification, as well as recycling of rechargeable batteries are involved, and the impacts of biomolecules on electrochemical properties are particularly emphasized. Finally, perspectives on this interesting field are also provided.
The Effect of Halide Composition on the Luminescent Properties of Ternary Cesium–Copper Halide Pseudo‐Perovskite Films
Authors: Samu Gergely Ferenc , Zsigmond Tamás Sándor , Hajdu Cintia , Hunyadi Mátyás , Csige Lóránt , Csík Attila , Kopniczky Judit , Hopp Béla , Janáky Csaba 
Published: July 2023

AbstractTernary copper halide pseudo‐perovskites are in the forefront of research as potential active materials in light emission applications. The optoelectronic properties of these compounds can be fine‐tuned by the preparation of mixed‐halide compositions. After irradiation, self‐trapped excitonic states are formed in these materials. However, the emission from these self‐trapped states is not yet fully understood. In this work, mixed‐halide Cs3Cu2X5 films (where X: I and/or Br) are prepared by a simple spray‐coating method. Using ultraviolet photoelectron spectroscopy, the changes in optoelectronic properties are linked to the electronic structure of these materials. It is revealed that the incorporation of bromide into the lattice makes the emission process of these materials more vulnerable to trap states. By combining the different spectroscopic characterization techniques, the exact band structure of these compounds is determined, and the different processes are translated to the absolute energy scale. As an alternative excitation mechanism of self‐trapped states, α‐particles are used to induce radioluminescence response. The Cs3Cu2X5 films exhibit composite decay patterns, most likely attributed to a multitude of different trap state‐mediated recombination processes.
Assessing the impact of sanitization methods for regenerated cellulose ultrafiltration/diafiltration membrane on membrane integrity and protein quality
Authors: Cong Xiaoji , Chen Wei , Wang Li , Wan Yan 
Published: July 2023

AbstractUltrafiltration/diafiltration (UF/DF) is typically the final step in downstream processing of recombinant monoclonal antibody (mAb) products, which serves for protein concentration and buffer exchange. For UF/DF membranes composed of regenerated cellulose (RC), sanitization with 0.1 M sodium hydroxide is generally recommended by the supplier, but it may not be sufficient for reducing bioburden during large scale manufacturing. Therefore, more stringent sanitization methods for RC membranes are required. However, chemicals used in such sanitization step may disrupt membrane integrity, while the corresponding residuals may reduce product quality. Previous work has shown that high concentration of sodium hydroxide or addition of peracetic acid (PAA) can effectively reduce bioburden, but their effects on the RC membranes remain unknown. In this work, we assessed the impact of two sanitization methods, 0.5 M sodium hydroxide and 30 mM PAA in combination with 0.5 M sodium hydroxide, on membrane integrity and protein quality of Millipore and pall corporation (PALL) membranes. Both methods showed a similar impact as the control after performing 15 cycles. However, the addition of PAA may cause residual chemical concerns, therefore, 0.5 M sodium hydroxide was recommended as an effective and safe sanitization method for RC UF/DF membranes.
Synthesis and Characterization of Novel 1,3‐Diaryltriazene‐Substituted Sulfaguanidine Derivatives as Selective Carbonic Anhydrase Inhibitors: Biological Evaluation, in Silico ADME/T and Molecular Docking Study
Authors: Akocak Suleyman , Lolak Nebih , Duran Hatice Esra , Işık Mesut , Türkeş Cüneyt , Durgun Mustafa , Beydemir Şükrü 
Published: July 2023

AbstractSulfonamide compounds known as human carbonic anhydrase (hCA) inhibitors are used in the treatment of many diseases such as epilepsy, antibacterial, glaucoma, various diseases. 1,3‐diaryl‐substituted triazenes and sulfaguanidine are used for therapeutic purposes in many drug structures. Based on these two groups, the synthesis of new compounds is important. In the present study, the novel 1,3‐diaryltriazene‐substituted sulfaguanidine derivatives (SG1‐13) were synthesized and fully characterized by spectroscopic and analytic methods. Inhibitory effect of these compounds on the hCA I and hCA II was screened as in vitro. All the series of synthesized compounds have been identified as potential hCA isoenzymes inhibitory with KI values in the range of 6.44±0.74‐86.85±7.01 nM for hCA I and with KI values in the range of 8.16±0.40‐77.29±9.56 nM for hCA II. Moreover, the new series of compounds showed a more effective inhibition effect than the acetazolamide used as a reference. The possible binding positions of the compounds with a binding affinity to the hCA I and hCA II was demonstrated by in silico studies. In conclusion, compounds with varying degrees of affinity for hCA isoenzymes have been designed and as selective hCA inhibitors. These compounds may be potential alternative agents that can be used to treat or prevent diseases associated with glaucoma and hCA inhibition.
Chemical Composition, Antimicrobial, Nitric Oxide Inhibition and Cytotoxic Activity of Essential Oils from Zanthoxylum acanthopodium DC. Leaves and Stems from Vietnam
Authors: Diep Trinh Thi , Dung Luong Van , Trung Phung Van , Hoai Nguyen Thi , Thao Do Thi , Uyen Nguyen Thi To , Linh Tran Thi Hoai , Ha Trang Hanh Nhat , Truc Huynh Thanh 
Published: July 2023

AbstractThis study was aimed to investigate the chemical composition and biological activities of leaf and stem essential oils of Zanthoxylum acanthopodium DC. from Vietnam. Their chemical composition was analyzed by GC/MS. Antimicrobial activities were evaluated by microdilution broth assay. Anti‐inflammatory activity was evaluated by the ability to inhibit nitric oxide production in macrophage cells. Cytotoxic activity was evaluated using the sulforhodamine B assay on three human cancer cell lines. Forty‐four compounds were identified in the leaf oil, among which dehydroaromadendrane (23.4 %), (E)‐carpacin (17.6 %), 2‐tridecanone (12.2 %), and 9‐methyl‐2‐decanone (11.8 %) were the most abundant. The stem oil contained fifty‐five identified constituents, mainly γ‐gurjunene (51.1 %) and butyl acetate (11.8 %). Both oils exhibited inhibitory effects on three bacterial strains, namely S. aureus, E. coli, P. aeruginosa and a fungal strain C. albican, while showed insignificant effects on B. subtilis, L. fermentum, and S. enterica. Both oils showed weak NO production inhibition in LPS‐induced RAW264.7 cells, but exhibited potent cytotoxic activity against all three tested cell lines SK‐LU‐1, MCF‐7, and HepG2 with the IC50 values ranging from 16.03±0.77 to 35.60±1.62 μg/mL. This is the first report on the antimicrobial, anti‐inflammatory and cytotoxic activities of essential oils from the leaves and stems of Z. acanthopodium.
Loss of TSC1 in secondary angiosarcoma of the breast
Authors: Rose Lucy , Owusu‐Brackett Nicci , Moore Stephen , Oppong Bridget 
Published: July 2023

Key Clinical MessagePost‐radiation angiosarcoma of the breast is a rare complication associated with a poor prognosis. This case reports the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma and illustrates the utility of evaluating these markers to identify potential therapeutic targets.AbstractPost‐radiation angiosarcoma of the breast is rare and associated with a poor prognosis. This case presents the first loss of function mutation in TSC1 in breast radiation‐induced angiosarcoma. Evaluation of these markers can aid in identifying potential therapeutic targets.
Highly Efficient Luminescence from a Red Thermally Activated Delayed Fluorescence Emitter with Flexible Conformation of Ancillary Groups
Authors: Jin Yu‐Xin , Chen Zi‐Qi , Zhang Kai , Yang Chen‐Zong , Pan Ze‐Hui , Ding Lei , Sun Yan‐Qiu , Wang Chuan‐Kui , Fung Man‐Keung , Fan Jian 
Published: July 2023

AbstractRobust scaffolds were typically applied in thermally activated delayed fluorescence (TADF) molecules to suppress the non‐radiative decay, trigger the fast spin‐flipping, and enhance the light out‐coupling efficiency. Herein, we disclosed for the first time the positive effect of flexible conformation of ancillary groups on the photophysical properties of TADF emitter. The red TADF emitter Ph‐TPA with flexible conformation demonstrated small excited‐state structural distortion and low reorganization energy compared to the counterpart Mc‐TPA with a rigid macrocycle. Consequently, Ph‐TPA showed an excellent photoluminescent quantum yield (PLQY) of 92 % and a state‐of‐the‐art external quantum efficiency (EQE) of 30.6 % at 630 nm. This work could deepen our understanding of structure‐property relationships of organic luminophores and help us to rationalize the design of efficient TADF materials.
Changing consumer attitudes to make the Corporate Social Responsibility investment in sustainable fish production, a worthwhile investment to corporates
Authors: Hlophe Simphiwe Lincon , Ellis Debbie 
Published: July 2023

AbstractThe need for environmental protection, especially of depleting natural resources such as fish stocks, remains a global challenge. Global population growth increases food consumption. Some socially responsible corporate entities in the fish sector are producing and selling sustainable fish products, but beyond meeting their altruistic motives, they need consumers to respond favorably to these CSR initiatives to make the investments worthwhile and to encourage more organizations to invest in CSR for sustainable development. This paper reports the findings of research on the factors which influence consumers in the emerging market of South Africa, to respond favorably to sustainable fish product CSR initiatives. A causal research design and quantitative method was employed with a sample of consumers who were part of the South African LinkedIn community and who eat fish, whether concerned or not about sustainability. An online questionnaire was developed using an extension of the Theory of Planned Behavior. Univariate, regression and mediation analyses were carried out. Attitude towards sustainable fish products was found to be the only significant predictor of intention to purchase sustainable fish but it was also found to mediate the impact of health consciousness and environment concern. This paper thus focuses specifically on the role of attitudes in sustainable fish consumption in South Africa. Recommendations are provided for improving these consumer responses so as to make these CSR investments worthwhile to corporates and thus also positively impact fish sustainability.
Creating Conjugated C−C Bonds between Commercial Carbon Electrode and Molecular Catalyst for Oxygen Reduction to Hydrogen Peroxide
Authors: Biemolt Jasper , Meeus Eva J. , de Zwart Felix J. , de Graaf Jeen , Laan Petrus C. M. , de Bruin Bas , Burdyny Thomas , Rothenberg Gadi , Yan Ning 
Published: July 2023

AbstractImmobilizing molecular catalysts on electrodes is vital for electrochemical applications. However, creating robust electrode‐catalyst interactions while maintaining good catalytic performance and rapid electron transfer is challenging. Here, without introducing any foreign elements, we show a bottom‐up synthetic approach of constructing the conjugated C−C bond between the commercial Vulcan carbon electrode and an organometallic catalyst. Characterization results from FTIR, XPS, aberration‐corrected TEM and EPR confirmed the successful and uniform heterogenization of the complex. The synthesized Vulcan‐LN4−Co catalyst is highly active and selective in the oxygen reduction reaction in neutral media, showing an 80 % hydrogen peroxide selectivity and a 0.72 V (vs. RHE) onset potential which significantly outperformed the homogenous counterpart. Based on single‐crystal XRD and NMR data, we built a model for density functional theory calculations which showed a nearly optimal binding energy for the *OOH intermediate. Our results show that the direct conjugated C−C bonding is an effective approach for heterogenizing molecular catalysts on carbon, opening new opportunities for employing molecular catalysts in electrochemical applications.
Governmental responses mitigating the impact of COVID‐19 on small and medium‐sized enterprises and the case for insolvency law reforms in Hong Kong
Authors: Wan Wai Yee 
Published: July 2023

AbstractThe COVID‐19 crisis has triggered unprecedented governmental responses around the world to mitigate the effects of the pandemic, with particular attention being given to small and medium‐sized enterprises (SMEs). Governments around the world have implemented economic measures in the form of direct subsidies or government‐guaranteed loans, and legislated to provide mandatory relief from contractual obligations. In addition, increasing recognition of the limitations of insolvency regime in addressing the crisis for SMEs prompted many jurisdictions to change their laws. However, consistent with its free market principles, Hong Kong has only adopted economic measures and has provided limited contractual relief in favour of SME tenants. There is no SME‐specific insolvency law nor is the Hong Kong government currently considering any such law reform. This article reviews the need for a temporary insolvency regime to cater to distressed but economically viable SMEs restructure their debts. Drawing on a set of interviews with Hong Kong SME owners, this author finds that they are often unaware of how insolvency law operates, their unsecured creditors are apathetic, and bankruptcy stigmatism is high. Based on a review of the frameworks in the other advanced common law jurisdictions such as the United States, Australia and Singapore, a recommendation for a simplified restructuring and liquidation framework is developed. The process is designed to be simplified and expedited and it incentivises early negotiations with creditors.
A contrast of the popularity and the interpretation of non‐GAAP earning disclosures in different industries
Authors: Cheng Kang , Tavakolifar Mohammad , Ullah Barkat 
Published: July 2023

AbstractThis study examines non‐GAAP disclosures in two selected industries, the consumer nondurable goods industry and the business services industry, to address the question of whether non‐GAAP measures are applied and interpreted uniformly across industries, and more importantly, if the market reacts to non‐GAAP disclosures similarly across different industries. Industry membership potentially has an impact on the usage and interpretation of non‐GAAP disclosures; some industries issue their own policy trying to standardize the use of non‐GAAP measures in their industry. However, industry effects on non‐GAAP disclosures have not been thoroughly studied. This study fills in the gap. Using hand‐collected non‐GAAP measures disclosed in the 8‐K reports from 308 firms in the selected two industries, this study finds that: (1) the use of non‐GAAP measures is more popular than reported in previous studies, and non‐GAAP measures are not limited to performance measures; (2) there is weak evidence of industry preference as to which non‐GAAP measures are more popular in that industry; and (3) the market reacts differently to non‐GAAP disclosures in different industries. Combining the empirical findings, this study documents industry effects and market reactions in the interpretation of non‐GAAP disclosures. Considering that these effects have not been formally academically documented in previous studies, this study carries practical implications for investors and financial analysts.
Enhancing the Iodine Adsorption Capacity of Pyrene‐Based Covalent Organic Frameworks by Regulating the Pore Environment
Authors: Gao Chao , Guan Xuhui , Zhang Menghui , Hu Haoran , Chen Lei , Sun Chengguo , Zhang Chong , Du Yang , Hu Bingcheng 
Published: July 2023

AbstractRegulating of pore environment is an efficient way to improve the performance of covalent organic frameworks (COFs) for specific application requirements. Herein, the design and synthesis of two pyrene‐based 2D COFs with ‐H or ‐Me substituents, TFFPy‐PPD‐COF and TFFPy‐TMPD‐COF are reported. Both of them show long order structure and high porosity, in which TFFPy‐PPD‐COF displays a larger pore volume and bigger BET surface area (2587 m2 g−1, 1.17 cm3 g−1). Interestingly, TFPPy‐TMPD‐COF exhibits a much higher vapor iodine capacity (4.8 g g−1) than TFPPy‐PPD‐COF (2.9 g g−1), in contrast to their pore volume size. By using multiple techniques, the better performance of TFPPy‐TMPD‐COF in iodine capture is ascribed to the altered pore environment by introducing methyl groups, which contributes to the formation of polyiodide anions and enhances the interactions between the frameworks and iodine. These results will be helpful for understanding the effect of pore environment in COFs for iodine uptake and constructing novel structure with high iodine capture performance.
TRAF6 regulates autophagy and apoptosis of melanoma cells through c‐Jun/ATG16L2 signaling pathway
Authors: Guo Yeye , Zhang Xu , Li Jie , Zhou Zhe , Zhu Susi , Liu Waner , Su Juan , Chen Xiang , Peng Cong 
Published: July 2023

AbstractAutophagy and apoptosis are essential processes that participate in cell death and maintain cellular homeostasis. Dysregulation of these biological processes results in the development of diseases, including cancers. Therefore, targeting the interaction between apoptosis and autophagy offers a potential strategy for cancer therapy. Melanoma is the most lethal skin cancer. We previously found that tumor necrosis factor receptor‐associated factor 6 (TRAF6) is overexpressed in melanoma and benefits the malignant phenotype of melanoma cells. Additionally, TRAF6 promotes the activation of cancer‐associated fibroblasts in melanoma. However, the role of TRAF6 in autophagy and apoptosis remains unclear. In this study, we found that knockdown of TRAF6 induced both apoptosis and autophagy in melanoma cells. Transcriptomic data and real‐time PCR analysis demonstrated reduced expression of autophagy related 16 like 2 (ATG16L2) in TRAF6‐deficient melanoma cells. ATG16L2 knockdown resulted in increased autophagy and apoptosis. Mechanism studies confirmed that TRAF6 regulated ATG16L2 expression through c‐Jun. Importantly, targeting TRAF6 with cinchonine, a TRAF6 inhibitor, effectively suppressed the growth of melanoma cells by inducing autophagy and apoptosis through the TRAF6/c‐Jun/ATG16L2 signaling pathway. These findings highlight the pivotal role of TRAF6 in regulating autophagy and apoptosis in melanoma, emphasizing its significance as a novel therapeutic target for melanoma treatment.
Snowed in? An analysis of social and transportation networks in the 2015 Boston Snowmageddon
Authors: Page‐Tan Courtney , Aldrich Daniel P. 
Published: July 2023

AbstractContinuous subzero temperatures and an unrelenting Polar vortex turned the 2014–2015 Boston winter into a compound disaster, causing deaths and roof collapses, shutting down businesses, and paralyzing transportation networks. Little is known about the circumstances, which enhanced community resilience and reduced impacts during this extended disaster. Using original surveys of more than 140 affected community members alongside demographic data from census and ESRI sources and GIS data on bus and rail networks, we investigate the factors that allowed vulnerable communities to overcome the crisis. Through mixed‐methods approaches, including GIS spatial analysis, multiple regression, average treatment effects, and propensity score matching, we illuminate the factors that helped urban residents mitigate the impact of the Boston snowstorms. Controlling for a number of potential confounding variables, including demographic and economic factors and transportation access, we find that bonding social ties served as a significant mitigating force during the crisis. These findings bring with them important public policy findings for residents, NGOs, and decision‐makers alike as we struggle to adapt to extreme weather events amidst increasing urbanization.
Armored probiotics for oral delivery
Authors: Yang Xinyuan , Wang Chong , Wang Qiao , Zhang Zhuohao , Nie Weimin , Shang Luoran 
Published: July 2023

AbstractAs a kind of intestinal flora regulator, probiotics show great potential in the treatment of many diseases. However, orally delivered probiotics are often vulnerable to unfriendly gastrointestinal environments, resulting in a low survival rate and decreased therapeutic efficacy. Decorating or encapsulating probiotics with functional biomaterials has become a facile yet useful strategy, and probiotics can be given different functions by wearing different armors. This review systematically discusses the challenges faced by oral probiotics and the research progress of armored probiotics delivery systems. We focus on how various functional armors help probiotics overcome different obstacles and achieve efficient delivery. We also introduce the applications of armor probiotics in disease treatment and analyze the future trends of developing advanced probiotics‐based therapies.