bluuebunny/crossref_metadata_2025_split huggingface dataset:
1,3-thiazole Derivatives: A Scaffold with Considerable Potential in the
Treatment of Neurodegenerative Diseases
Authors: Chaudhary Jasmine , Jain Akash , Dhingra Ashwani , Chopra Bhawna , Sharma Vishal , Gupta Jatin , Kaushik Aditi 
Published: July 2023

Abstract:
1,3-thiazoles, which contain nitrogen and a sulfur atom is an unsaturated five-membered
heterocyclic ring, have achieved a unique significant place in drug design and development because
of their versatile structure and a variety of pharmacological activities, viz. anticancer, antiviral,
antimicrobial, anticonvulsant, antioxidant, antidiabetic, etc. They have inspired researchers to
design novel thiazole with different biological activities. The presence of the thiazole moiety has resulted
in a large number of clinically useful drugs with a wide range of activities, such as Ritonavir
(antiviral), Sulfathiazole (antimicrobial antibiotic), Abafungin, Ravuconazole (antifungal), Meloxicam
(NSAID), etc., that further verify this statement. The prevalence of neurodegenerative diseases
like Alzheimer's, Parkinson's, and Huntington’s is increasing at a rapid pace but existing treatments
mainly provide symptomatic relief and are associated with undesired effects. Consequently, designing
novel compounds with more effectiveness and reduced toxicity are required. 1,3-thiazole derivatives
have emerged as excellent candidate in this regard and have an important role for the treatment
of neurodegenerative diseases. In the current review, we have gathered all the appropriate literature
which demonstrate the remarkable role of 1,3-thiazole and its derivatives in these diseases
that may help design new compounds with more desired characteristics. The literature was assessed
through worldwide scientific databases like GOOGLE, SCOPUS, and PUBMED using different
keywords, and only relevant information published in English was evaluated.
Przynależność do grupy rówieśniczej a zażywanie substancji psychoaktywnych w aspekcie profilaktycznej roli pielęgniarki
Authors: Krawczyk Marta 
Published: July 2023

Wstęp. Poczucie własnej wartości u nastolatka jest zagadnieniem zasługującym na naszą uwagę. Dojrzewanie jest etapem pełnym zmian. Jest to czas ciągłego rozwoju, poszukiwania swojego miejsca w grupie rówieśniczej. Młodzież czuje ciągłą potrzebę eksperymentowania, dlatego jest narażona na uzależnienia od środków psychotropowych. Działania edukacyjne i profilaktyczne prowadzone przez opiekunów i pielęgniarki odgrywają znaczącą rolę w zapobieganiu powstawania uzależnień i stanów zagrożenia życia.
Cel. Celem pracy było zbadanie wpływu potrzeby przynależności do grupy rówieśniczej na rozpoczęcie zażywania dopalaczy i palenia marihuany.
Materiał i metody. Użytą metodą badawczą była metoda sondażu diagnostycznego, techniką badawczą było przeprowadzenie ankiety, a narzędziami badawczymi był Kwestionariusz KIDSCREEN, Test PUN, PUM oraz kwestionariusz ankiety własnego autorstwa. Badanie przeprowadzono wśród 104 osób od 16 do 19 roku życia.
Wyniki. Według analizy wyników badań dopalacze stają się mniej popularne, a marihuana trafia do coraz liczniejszej grupy odbiorców na co wpływ ma potrzeba przynależności do grupy rówieśniczej. Aż 23% nastolatków uważa, że zapalenie marihuany poprawiło ich kontakt z koleżankami i kolegami, a większość z nich również pali.
Wnioski. Relacja z rówieśnikami wpływa na decyzję o zapaleniu marihuany, nie ma wpływu na osoby zażywające dopalacze. Na osoby decydujące się na inicjację narkotykową nie wpływa również pewność siebie, relacja z rówieśnikami oraz rodzicami.
Effective Prediction of Mortality by Heart Disease Among Women in Jordan Using the Chi-Squared Automatic Interaction Detection Model: Retrospective Validation Study
Authors: Bani Hani Salam , Ahmad Muayyad 
Published: July 2023

Background
Many current studies have claimed that the actual risk of heart disease among women is equal to that in men. Using a large machine learning algorithm (MLA) data set to predict mortality in women, data mining techniques have been used to identify significant aspects of variables that help in identifying the primary causes of mortality within this target category of the population.

Objective
This study aims to predict mortality caused by heart disease among women, using an artificial intelligence technique–based MLA.

Methods
A retrospective design was used to retrieve big data from the electronic health records of 2028 women with heart disease. Data were collected for Jordanian women who were admitted to public health hospitals from 2015 to the end of 2021. We checked the extracted data for noise, consistency issues, and missing values. After categorizing, organizing, and cleaning the extracted data, the redundant data were eliminated.

Results
Out of 9 artificial intelligence models, the Chi-squared Automatic Interaction Detection model had the highest accuracy (93.25%) and area under the curve (0.825) among the build models. The participants were 62.6 (SD 15.4) years old on average. Angina pectoris was the most frequent diagnosis in the women's extracted files (n=1,264,000, 62.3%), followed by congestive heart failure (n=764,000, 37.7%). Age, systolic blood pressure readings with a cutoff value of >187 mm Hg, medical diagnosis (women diagnosed with congestive heart failure were at a higher risk of death [n=31, 16.58%]), pulse pressure with a cutoff value of 98 mm Hg, and oxygen saturation (measured using pulse oximetry) with a cutoff value of 93% were the main predictors for death among women.

Conclusions
To predict the outcomes in this study, we used big data that were extracted from the clinical variables from the electronic health records. The Chi-squared Automatic Interaction Detection model—an MLA—confirmed the precise identification of the key predictors of cardiovascular mortality among women and can be used as a practical tool for clinical prediction.
Transformasi Budaya Permainan Tradisional Ke Game Online Pada Remaja Di Desa Wonosari Kabupaten Jember
Authors: Wismawati Anik Fitri , Kamila Annisa Dini , Febrianti Putri Amalia , Riska Fitriyah  
Published: July 2023

The rapid development of technology has contributed to influencing various aspects of life, one of which is culture in society. The game is one aspect of culture that has also experienced a change from the previous traditional game to an online game. Online games have become widely used since the pandemic hit in 2020. This has led to the change in social interaction that was formerly patembayan, to become individualism. This study aims to reveal the transition of game culture change in adolescents. This research was carried out using a qualitative approach and the research method used was ethnography in Wonosari Village, Jember Regency, East Java Province. Data collection was carried out through interviews and observations with adolescents in Wonosari Village using purposive sampling as the target of this study. The results of the study show that in the transition process starting from the invitation of friends and small habits it is what makes addiction and results in cultural change. Then this cultural change also produces a domino effect with changes in social interaction in adolescents.
ABSTRAK
Perkembangan teknologi yang semakin pesat turut andil dalam memengaruhi berbagai aspek dalam kehidupan, salah satunya kebudayaan pada masyarakat. Permainan merupakan salah satu aspek dalam kebudayaan juga turut mengalami perubahan dari sebelumnya permainan tradisional menjadi Game Online. Game Online menjadi marak digunakan sejak pandemic melanda pada 2020 silam. Hal ini, membuat ikut berubahnya interaksi sosial yang sebelumnya patembayan, menjadi individualism. Penelitian ini bertujuan untuk mengungkap transisi perubahan kebudayaan permainan pada remaja. Penelitian ini dilaksanakan dengan menggunakan pendekatan kualitatif dan metode riset yang digunakan ialah etnografi di Desa Wonosari, Kabupaten Jember, Provinsi Jawa Timur. Pengumpulan data dilakukan melalui wawancara dan observasi dengan remaja di Desa Wonosari secara purposive sampling sebagai sasaran penelitian ini. Hasil penelitian menunjukkan bahwa dalam proses transisinya dimulai dari ajakan teman dan kebiasaan kecil tersebutlah yang menjadikan kecanduan dan menghasilkan perubahan kebudayaan. Kemudian, perubahan kebudayaan ini juga turut menghasilkan efek domino dengan adanya perubahan interaksi sosial pada remaja
Molecular Environment of the Thermal Composite Supernova Remnant G352.7-0.1
Authors: Zhang Qian-Qian , Zhou Ping , Chen Yang , Zhang Xiao , Zhong Wen-Juan , Zhou Xin , Zhang Zhi-Yu , Vink Jacco 
Published: July 2023

Abstract
Galactic supernova remnants (SNRs) play an important role in our understanding of supernovae and their feedback on the interstellar environment. SNR G352.7-0.1 is special for its thermal composite morphology and double-ring structure. We have performed spectroscopic mapping of the 12CO and 13CO J = 2–1 lines toward G352.7-0.1 with the Atacama Pathfinder Experiment telescope. Broad 12CO lines are found in the northeastern ring at a local-standard-of-rest velocity range of ∼−50 to −30 km s−1, suggesting that the remnant is interacting with molecular clouds at ∼−51 km s−1. Thus, we adopt a distance of ∼10.5 kpc for this SNR. The momentum and kinetic energy of the shocked gas along the line of sight are estimated to be ∼102
M
☉ km s−1 and ∼1046 erg, respectively. We also find an expanding structure around the remnant, which is possibly related to the wind-blown bubble of the progenitor star. From Fermi-LAT data in the energy range 0.1–500 GeV, we find no gamma-ray counterparts to G352.7-0.1.
THE IMPACT OF LIFE-COURSE SOCIO-ECONOMIC POSITION ON QUALITY OF LIFE AT LATER AGES : EVIDENCE FROM ESTONIA
Authors: Sakkeus Luule , Saar Ellu , Rudissaar Uku 
Published: July 2023

This study, guided by life-course theory and cumulative (dis)advantage theory, investigates the impact of the accumulation of socio-economic advantages and disadvantages, over the life course, on the quality of life (QoL) of the older population, and the mediating role of their current financial distress. In our study, we focus on the accumulation model. The study primarily uses data from Estonia in wave 4 of the Survey of Health, Ageing and Retirement in Europe (SHARE), with supplemental data from wave 5. Linear regression models were calculated based on two measures of quality of life : CASP-12 and life satisfaction. When measured by CASP-12, the socio-economic position in adulthood seems to play a more important role than that of childhood for the current quality of life of older people and even seems to compensate for it slightly when the current financial distress level is controlled for. However, when measured by life satisfaction, accumulated socio-economic (dis)advantages, especially in early youth, have a greater impact on the current quality of life of older people. It is important to acknowledge that different measures of QoL might yield different results.
Do Bone Mineral Density, Trabecular Bone Score, and Hip Structural Analysis Differ in Indian Men with Parkinson’s Disease? A Case-Control Pilot Study from a Tertiary Center in Southern India
Authors: Sooragonda Basavaraj G. , Sridharan Kalyani , Benjamin Rohit Ninan , Prabhakar A. T. , Sivadasan Ajith , Kapoor Nitin , Cherian Kripa Elizabeth , Jebasingh Felix K. , Aaron Sanjith , Mathew Vivek , Asha Hesarghatta S. , Thomas Nihal , Paul Thomas V. 
Published: July 2023

Abstract

Objective:
Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson’s disease in India has not been studied thus far. This study aimed to assess the bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) in Indian men with PD and compare them with matched controls.

Methodology:
A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed.

Results:
Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state.

Conclusion:
A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.
Relationship Between Staff Nurse Motivation Level and Patient Satisfaction In Selected Hospital and the Appreiviation are Staff Nurse Motivation and Patient Satisfaction
Authors: Aly Howida Abo Elhamed , Abed Fatma Ahmed , Mohamed Maaly Zayed 
Published: July 2023

Background
Nursing is a core job in the healthcare system; nursing staff constitutes the largest human resource element in healthcare organizations and therefore they seem to have a great impact on the quality of care, patient outcome, and satisfaction. The study aimed to investigate the relationship between staff nurse motivation and patient satisfaction.

Design
A descriptive correlational design was used to achieve the aim of the current study.

Setting
The study was conducted at Soad Kafafy Private University Hospital.

Sample
Two groups of samples were selected: the staff nurses sample consisted of (100 staff nurses) and the patient sample consisted of 100 patients.

Tools
Two tools were used in the study the first: the patient satisfaction questionnaire assesses patient satisfaction; it contains seven dimensions with a total of 51 items and the second: the staff nurses’ motivation questionnaire developed by the researchers to assess the nurses’ motivational factors. It contains seven dimensions with a total of 48 items.

Result
The results showed that there is a positive correlation between patient's satisfaction and nurse's motivation.

Conclusion
There was a significant relationship between staff nurses’ motivation and patient satisfaction.

Recommendations
The study recommended that hospitals should adopt motivation strategy for their nurses to motivate them, ensure nurses’ participation in decision-making processes that will enhance the clinical and organizational outcome, availability of motivation and incentive policies and procedures at every unit in the hospital, and further research should be done concentrating on adherences to motivational strategy.
Preoperative correlates of prolonged postoperative ileus among patients undergoing colorectal surgeries
Authors: Sayed Ola T. , Al Sebaee Hanan A. , Iskander Liliane I. 
Published: July 2023

Background
Prolonged postoperative ileus (PPOI) is one of the most common complications following colorectal surgeries, which leads to increased postoperative morbidity, mortality, and length of hospital stay.

Aim
The aim of this study was to examine preoperative correlates of PPOI among patients undergoing colorectal surgeries.

Design
A descriptive correlational research design was used in this study.

Setting
The study was conducted at selected General and Emergency Surgery Departments of Kasr El Eini Hospital affiliated to Cairo University hospitals.

Sample
A convenient sample of 60 adult male and female patients was recruited to answer the research question.

Results
The main study findings revealed that the incidence of PPOI occurred in 66.7% of patients. A statistically significant correlation was found between PPOI occurrence and surgical approach (laparotomy, 87%,and colectomy, 65%), duration of preoperative intravenous fluid administration (87.5%), preoperative antibiotics (55%), low hemoglobin and hematocrit level (72.5%), preoperative prolonged duration of fasting for liquids more than 24 h (57.5%), and lack of preoperative teaching about recovery plan for most of the study participants.

Conclusion
Preoperative correlates of PPOI according to the current study findings are the laparotomy surgical approach, the colectomy procedure, duration of intravenous fluids administration, low hemoglobin and hematocrit levels, prolonged fasting for liquids, and lack of teaching about preoperative recovery plan.

Recommendations
Further research studies are required to determine the best practice for prevention and reduction of PPOI incidence. Comprehensive education programs for health team members and the patients regarding the guidlines of caring for colorectal surgery within the context of enhanced recovery after surgery program are required.
Dorsal Plating for Distal Radius Fractures
Authors: Ajayakumar T. , Nizaj N. , Khan Prince Shanavas , Ajay Vidya , Johny Sanjai P. , Meleppuram Jimmy Joseph 
Published: July 2023

Aim:
This study aims to evaluate the radiological and functional outcome and also to assess the complication rates associated with dorsal plating of the distal radius with low profile plates.

Materials and Methods:
A single-centered, prospective study on 21 patients with unstable dorsally displaced distal radius fractures between March 2019 and March 2022. We used low-profile dorsal locking plates (Arthrex) for all the cases. The functional outcome was measured using VAS score, disabilities of the arm, shoulder, and hand (DASH) questionnaire, and Gartland and Werley Score. The arc of motion and grip strength were measured on the operated wrist and compared with the contralateral wrist. We also recorded the associated postoperative complications.

Results:
The study group contains 11 men and 10 women with a mean age of 49 years. The mean duration of follow-up was 18 months (range 12–32). There were no cases of malunion, extensor tendon irritation, infection, neuropathy, or implant failure. The radiological union was seen in all cases. The range of motion and grip strength of the operated wrist was found to be more than 95% of that of the contralateral wrist. The mean VAS score was 0.85, DASH score 4.75 ± 0.97, and Gartland and Werley score showed excellent outcomes for all 21 cases. The experimental demonstration on bone models showed poor mechanical stability by volar plates on shear-type fractures.

Conclusion:
The newer low-profile dorsal locking plate provides mechanical and structural stability to the dorsally displaced fractures, even in those with poor bone stock, and is associated with negligible soft-tissue complications. We strongly recommend using dorsal plates for all dorsally displaced fractures which are distal to or at the level of the watershed line.
The Use of Antibiotic-Loaded Absorbable Calcium Sulfate Beads in Open Fractures
Authors: Ajayakumar T. , Nizaj N. , Khan Prince Shanavas , Raju Aebel , Johny Sanjai P. , Ajay Vidya 
Published: July 2023

Aim:
The aim of our study was to evaluate the complication rates associated with open long bone fractures and to assess the bony union when antibiotic-loaded calcium sulfate beads were used with definitive fixation.

Materials and Methods:
A single-centered prospective study on 56 consecutive series of patients who had open fractures of long bones of different grades presented to our emergency department between April 2018 and March 2022. There were 68 long bone open fractures for these 56 patients. After evaluating the patient with advanced trauma life support protocol, the patient underwent wound debridement and primary definitive fixation. The unstable patients were managed with damage control procedures. We used absorbable vancomycin-loaded synthetic calcium sulfate beads in all cases while performing the definitive fixation. The follow-up was done at 2 weeks, 6 weeks, 12 weeks, 6 months and 12 months, and 6 months thereafter. We recorded complications such as infection, nonunion, delayed union, malunion, and implant loosening till the latest follow-up.

Results:
Fifty-six patients with long bone open fractures (39 males and 17 females) having a mean age of 44 years (range 17–68 years) were operated. There were 68 long bone open fractures for these 56 patients. We operated on 24 tibia, 17 femur, 10 ankle, 10 forearm, and 7 humerus open fractures. According to Gustilo-Anderson classification, there were 16 Type I, 12 Type II, and 40 Type III (Type IIIa-29, Type IIIb-6, and Type IIIc-5) fractures. We performed wound debridement and primary definitive fixation in 52 patients and delayed the definitive fixation in those who had other severe injuries to manage (16 cases). The mean follow-up period was 22 months (range: 14–42 months). The mean time for union was 2.4 months (range: 2–3.6 months). There were no cases of infection, nonunion, or delayed union in our study.

Conclusion:
Our research has demonstrated that meticulous debridement and early internal fixation of long bone open fractures in conjunction with antibiotic-impregnated calcium sulfate can lessen the risk of deep infection and enhance bone healing.
Elderly Abuse and Neglect in Long Term Care Facilities in America : A systematic Review
Authors: Mogaka  , Bistas Karlyle , Bistas Evangelos , Jaswal Anitesh , Raviendren Nirshanthika , Gautam Vivek 
Published: July 2023

Abstract
Hypothesis: Elderly abuse and neglect occurs as a result of lack of relevant personnel training, poor remuneration, and depression among caregivers. To test the hypothesis, overall findings analyzed confirm if they were in agreement or not.
Background: Reports of cases of elderly abuse and neglect have been on the increase. To add on to that, not enough studies exist that can be of help in guiding policy-makers to formulate solutions and offer answers as to why this problem is on the increase.
Method: These researchers conducted a review of existing literature about elderly abuse in order to better understand the risk factors and causes of elderly abuse and neglect. Information was mined from various databases that contained information relevant to this review.
Results: Results of findings showed that reports of abuse cases were on the rise, especially among the elderly patients; worse still for those with a secondary chronic illness like dementia and Parkinson’s Disease. Women reported more cases of abuse compared to those reported by men. By demographics, abuse was found to be much higher among minority groups like the African Americans and Asians Americans. Some elderly patients in the studies experienced concurrent types or forms of abuse. Those with severe forms of cognitive impairments reported the highest cases of abuse and self-neglect.
Conclusion: Better remuneration, continuous training to caregivers about aging and better healthcare skills are necessary to help to end this scourge. This study concludes that despite great efforts made by some institutions to end abuse and neglect, more publicity, more studies or research and more funds are required in order to build a sufficient body of knowledge that can be relied upon by the relevant policy-makers.