bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future predictions of wave and response of multiple floating bodies based on the Kalman filter algorithm
Authors: Isnaini Rodhiatul , Tatsumi Akira , Iijima Kazuhiro 
Published: February 2023

Abstract
The present work explores the possibility of predicting future waves by extending the Kalman filter algorithm by incorporating the spatial distance between two points. Experimental data at 2D tank are used to validate the effectiveness of the proposed method. When causality limitation is fulfilled, it is found that 3-8 s or several cycles of waves ahead can be predicted in model scale, depending on the distance between the two points. If a scaling of 1/100 is adopted, this means 30-80 s waves ahead can be estimated. The longer the distance, the longer future predictable time will be. Response predictions using wave prediction data are also investigated. The results for the response prediction also exhibits high accuracy, with even higher predictable future time (80-120 s ahead given 1/100 scale ratio) compared to its associated predictable future time of waves.
New organotin(IV) complexes derived from 1-adamantanethiol: Synthesis, structure, DFT calculation and in vitro bioactivities
Authors: Meng Zixuan , Zhang Rufen , Shi Hongliang , Ma Chunlin 
Published: February 2023

Abstract
Five new organotin(IV) complexes, Me2SnL2 (1), n-Bu2SnL2 (2), t-Bu2SnL2 (3), Ph2SnL2 (4), and Ph3SnL (5), have been designed and synthesized by the reactions of the deprotonated 1-adamantanethiol ligand (L = C10H15S) with the corresponding R2SnCl2 (R = Me, n-Bu, t-Bu, Ph) and Ph3SnCl. The newly synthesized complexes have been characterized by elemental analysis, FT-IR, NMR (1H, 13C and 119Sn) spectroscopy and X-ray crystallography. Structural analyses of the complexes reveal that the tin atoms of five complexes show tetrahedral structure. Meanwhile, optimized geometrical parameters, harmonic vibrational frequencies, frontier molecular orbitals were obtained with B3LYP method on complexes 1–5 for the further certificate of the measured experimental data to give theoretical support. Furthermore, the in vitro biological activities of complexes 1–5 were assessed with the HeLa (human cervical cancer cell line) and HepG-2 (human liver cancer cell line). For the result, complex 5 exhibited a high in vitro cytostatic activity. Also, the antifungal effects were evaluated, SEM and TEM images were prepared from Alternaria kikuchiana Tanaka to analyze the macroscopic action site of the drug on the fungus.
Density kernel depth for outlier detection in functional data
Authors: Hernández Nicolás , Muñoz Alberto , Martos Gabriel 
Published: February 2023

Abstract
In this paper we address the problem of outlier detection in the functional data context. To this end we define a functional depth measure via density kernels, that satisfies the desirable theoretical properties. We consider a Reproducing Kernel Hilbert Space (RKHS) model to get a low-dimensional and stable representation of the functions. Throughout a Monte Carlo simulation study we assess the performance of the functional depth in the outlier detection task, under different scenarios and outlier contamination settings. By means of an application to mortality rate curves we show the effectiveness of the proposed functional depth measure to pinpoint shape functional outliers whose visual identification is difficult.
Endovascular Thrombectomy for Acute Ischemic Stroke in Elderly Patients with Large Ischemic Cores
Authors: liu qian , fang jinghuan , jiang xin , duan ting , luo yaxi , gao lijie , dong shuju , ma mengmeng , zhou muke , He Li 
Published: February 2023

Abstract

Background: As the combined effects of advanced age and extensive brain infarction can have a greater negative impact on clinical outcomes, a real-world data analysis is necessary to fully understand the benefits and risks of endovascular therapy (EVT) in this population. Methods: The study retrospectively analyzed clinical outcomes for elderly stroke patients (age ≥ 70) with large ischemic cores (Alberta Stroke Program Early CT Score [ASPECTS] < 6 or ischemic cores ≥ 70 ml) in the anterior circulation using data from our prospective database between June 2018 and January 2022. The effectiveness and risks of EVT in those patients were investigated, with the primary outcome being fair outcome (modified Rankin Scale, mRS ≤ 3). Results: Among 182 elderly patients with large ischemic core volume (120 in the EVT group and 62 in the non-EVT group), 20.9% (38/182, 22.5% in the EVT group vs. 17.7% in the non-EVT group) achieved a fair outcome. Meanwhile, 49.5% (90/182, 45.8% in the EVT group vs. 56.5% in the non-EVT group) of them died at 3 months. EVT may help patients achieve functional independence. The benefits of EVT numerically exceeded non-EVT treatment for those aged ≤ ~ 85 years or with a mismatch volume ≥ ~ 50ml. However, EVT showed increased risk of symptomatic ICH after adjustment (aOR 7.279, 95%CI 1.131–46.845). Conclusion: This study highlights the significant clinical challenges faced by elderly patients with large infarction, with poor outcomes observed at 3 months. While EVT may offer some benefits, it also comes with increased risk of ICH.
Comparative analysis and risk assessment of dam-break floods: Taking Pingshuijiang Reservoir as an example
Authors: Jiang Xun , Meng Jie , Fan Bingjie , Zhao Chongxu , Zheng Yanshuang , Xiao Qianlu , Zhang Chunjin , Ma Dongfang 
Published: February 2023

Abstract
Due to the huge potential energy associated with water storage in reservoirs, dam-break floods are often catastrophically destructive for people and structures downstream. This study aims to simulate and compare floods generated under various dam-break scenarios and their downstream impacts, taking Pingshuijiang Reservoir in southeastern China as an example. A two-dimensional hydrodynamic model is used to simulate the downstream evolution of floods under three dam-break scenarios, and the breach flood and downstream inundation process are analyzed. Gradual failure of the main dam leads to near-total inundation of the nearby town over c. 1 h, allowing time for warning and evacuation. Instantaneous failure of the main dam results in larger peak flow, greater submergence depth and faster inundation (20 min), leaving little time for warning/evacuation. Instantaneous failure of the auxiliary dam generates a much lower peak flow magnitude and, although the town is still largely submerged within 45 min, the shallow water depth and low velocity are conducive to rescue/evacuation. The results show significant variation in flood process and submergence due to dam size and failure mode that provide guidance for dam-break flood risk assessment and disaster avoidance planning.
Exploration of Computational Aids for Effective Drug Designing and
Management of Viral Diseases: A Comprehensive Review
Authors: Khan Tahmeena , Raza Saman 
Published: February 2023

Background:
Microbial diseases, specifically originating from viruses are the major cause of human mortality all over the world. The current COVID-19 pandemic is a case in point, where the dynamics of the viral-human interactions are still not completely understood, making its treatment a case of trial and error. Scientists are struggling to devise a strategy to contain the pan-demic for over a year and this brings to light the lack of understanding of how the virus grows and multiplies in the human body.

Methods:
This paper presents the perspective of the authors on the applicability of computational tools for deep learning and understanding of host-microbe interaction, disease progression and man-agement, drug resistance and immune modulation through in silico methodologies which can aid in effective and selective drug development. The paper has summarized advances in the last five years. The studies published and indexed in leading databases have been included in the review.

Results:
Computational systems biology works on an interface of biology and mathematics and in-tends to unravel the complex mechanisms between the biological systems and the inter and intra species dynamics using computational tools, and high-throughput technologies developed on algo-rithms, networks and complex connections to simulate cellular biological processes.

Conclusion:
Computational strategies and modelling integrate and prioritize microbial-host interac-tions and may predict the conditions in which the fine-tuning attenuates. These microbial-host inter-actions and working mechanisms are important from the aspect of effective drug designing and fi-ne-tuning the therapeutic interventions.
The Anticancer Potentials of Substituted Indeno[1,2-b]quinoline Amines
against HT29 and SW620: Experimental and In silico Approach
Authors: Ökten Salih , Aydın Ali , Erkan Sultan , Tutar Ahmet 
Published: February 2023

Background:
This study aimed the determination of the antiproliferative and cytotoxic activities
of recently prepared indeno [1,2-b]quinoline amines against colon carcinoma, HT29 and SW620 cell
lines by using cell proliferation and cytotoxicity assays.

Methods:
In vitro inhibition of cell proliferation of indenoquinoline derivatives was determined with an
MTT cell proliferation assay. On the other hand, their cell cytotoxicities and apoptotic potential were
investigated by LDH cytotoxicity and DNA laddering assays. Moreover, molecular docking studies were
performed between the compounds and PDB ID: 1OLG and 4LVT target proteins using virtual scanning
techniques.

Results:
Most of the compounds (1, 3, and 7-9) exhibit much more potent antiproliferative activity than
positive controls against HT29 and SW620 cell lines (IC50 values 1.1 - 4.1 μg/mL) and show slightly
toxic properties (percent cytotoxicity 9.8% to 33.5%) to cells compared to positive control. On the other
hand, it was determined that effective compounds 1, 2, 3 and 9 stimulated apoptosis on HT29 and
SW620. Moreover, the anticancer effect of the recent indeno[1,2-b]quinoline amine derivatives was investigated
with the help of molecular docking simulations for their pharmacokinetics. The molecular
docking results displayed that mono bromo (1-3) and phenyl (7-9) substituted indeno [1,2-b]quinoline
amines interact with mutated p53 and protein Blc-2 residues with hydrogen bonding and polar interactions,
respectively.

Conclusion:
As a result, the preliminary experimental data and in silico studies indicated that the monosubstituted
indenoquinoline amine derivatives, especially 1, 3, and 7-9, exhibit effective pharmacological
properties.
Role of Apoptotic-targeted Phytoconstitutent-loaded Antipsoriatic
Nanobiocomposites
Authors: Singh  Patel Pankaj , Srivastava Rajnish , Panchawat Sunita 
Published: February 2023

ABSTRACT:
Psoriasis is an inflammatory and proliferative autoimmune dermatological disorder. It is a
skin ailment that is defined by particular, drab-red or peach-pink stiff areas with silvery scales patches.
Other typical characteristics include the proliferation of epidermal layer, aberrant keratinization,
hyperkeratosis, increased micro capillary vascularization, and infiltration of inflammatory mediator
loaded cells. Conventional pharmacotherapies currently available can only provide minor advantages.
Nanomedicines based on nanotechnology can potentially improve the efficacy and safety
of psoriasis medications. Apoptosis plays an important pathogenetic role in many chronic inflammatory
diseases, including those of dermatological interest, in particular, regarding psoriasis. In this regard,
treatments with antioxidant properties could be appropriate therapeutic options. We reviewed
the available studies on the efficacy of antiapoptotic therapies in psoriasis. We'll look at phytochemicals
in this review, which are natural components found in plants with antiapoptotic activity that are
frequently used to treat psoriasis. For improved topical treatment, we also take into consideration the
advantages of loading phytoconstituents as medicines into lipid based nanocarriers. The utilization of
herbal nanomedicines in psoriasis, as well as nano delivery carrier system for phytoconstituents with
improved therapeutic profiles and decreased toxicity, are the subjects of this review. The study's purpose
is to find more effective herbal nanomedicines for treating psoriasis. In the treatment of psoriasis,
phytoconstituents that have shown antipsoriatic potential in recent years, as well as phytoconstituents
loaded based nanomedicines, have a lot of promising roles to be explored. Furthermore, very
few patents have been found in the field of nanotechnology utilizing lipid-based nanocarrier system
for the treatment of psoriasis. Therefore, this review greatly compels the researcher to validate the
process development of lipid-based drug delivery system for the patentability of the product. This
should be in a view of shifting in the applicability of the drug delivery system for general public
health as a potential treatment option in psoriasis.
Microscopic Evidence of the Behavior of pH-sensitive Food-grade
Polymeric Delivery Systems
Authors: Carbone Claudia , Pignatello Rosario , Rizzo Salvatore , Cosentino Giuseppe , Zingale Elide , Bonaccorso Angela , Petralia Salvatore , Monforte Francesca , Condorelli Guglielmo G. 
Published: February 2023

Background:
Colon delivery systems are designed for the oral delivery of active compounds in the large intestine. Food-grade copolymers Eudraguard® Biotic (EUGB) and control (EUGC) have been investigated to develop colloidal systems loading natural active ingredients.

Methods:
In this study, we evaluated the degradation process of these matrices in simulated gastric, intestinal and colonic conditions. Microparticles made of EUGB and EUGC, alone or in combination, were loaded with the model compound resveratrol (RSV). A parallel study was performed on in vitro RSV release and SEM analysis of microparticles kept at different pH values.

Results:
All systems ensured a limited gastric release of RSV (below 20%), presenting only small pores on the surface of microparticles treated with simulated gastric fluid. EUGB microparticles showed the maximum release in simulated colon fluid (SCF), showing a complete dissolution of the microparticle matrix. The EUGC-based system allowed a prolonged release of RSV over time, and in SCF, it showed only partial degradation. Using mixed EUGB/EUGC matrices, a prolonged RSV release was observed along the intestinal tract.

Conclusion:
Overall, EUGB and EUGC copolymers were able to modulate and localize the release of entrapped cargo in the small intestine and colon. They could have interesting applications in treating bowel diseases synergistically with other therapeutic strategies.
DISRUPTION: HIDING IN PLAIN SIGHT
Authors: Kelshall Candyce 
Published: February 2023

On November 21, 2022, Candyce Kelshall, president of CASIS Vancouver and vice chair at the Canadian Intelligence Network, presented Disruption: Hiding in Plain Sight at the 2022 CASIS Vancouver West Coast Security Conference. The key points discussed were the distinction of Generation Z and Alpha from previous generations, their presence in the online and offline worlds, cyber- and soft war and its implication in the West and in Ukraine, Russia building new partnerships, the survival of liberal democracy, and Canada’s role in ensuring the survival of liberal democracy.

Received: 2023-01-16Revised: 2023-01-26
LEVERAGING DIVERSITY, EQUALITY, AND INCLUSION (DEI) IN MEETING MODERN INTELLIGENCE CHALLENGES
Authors: Tessier Michelle 
Published: February 2023

On November 22, 2022, Ms. Michelle Tessier, Deputy Director of Operations, Canadian Security Intelligence Service (CSIS), presented on Leveraging Diversity, Equity, and Inclusion (DEI) in Meeting Modern Intelligence Challenges. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the ways in which DEI strategy helps the government of Canada deliver programs and services to all Canadians and examples of steps taken to ensure the implementation of such strategy.

Received: 2022-12-10Revised: 2022-12-30
EN(COUNTERING) TERRORISM
Authors: Bloom Mia 
Published: February 2023

On November 23, 2022, Dr. Mia Bloom, Communications and Middle East Studies professor at Georgia State University, presented on “En(countering) Terrorism” at the 2022 Annual CASIS Vancouver West Coast Security Conference. The key points discussed were the changing roles of women in terrorist groups, the relationship between social media and terrorist groups, and the emergence of the QAnon movement.

Received: 2023-01-08Revised: 2023-01-17
CYBER SECURITY, DATA PROTECTION, AND PRIVACY IN A CONTESTED GEO-POLITICAL ENVIRONMENT
Authors: Shull Aaron 
Published: February 2023

On November 25, 2022, Aaron Shull, Managing Director, and General Counsel for the Centre for International Governance Innovation (Canada) presented on Cyber Security, Data Protection, and Privacy in a Contested Geo-Political Environment. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were privacy rights—their limitations, relationship with technology, and overall value— as well as data exploitation and the need for improving cyber security postures for Small and Medium-sized Enterprises (SMEs).

Received: 2022-12-27Revised: 2023-01-12
CLOSING REMARKS: CYBER RESILIENCE AND INTERNATIONAL PERSPECTIVES PANEL — 2022 WEST COAST SECURITY CONFERENCE
Authors: Kelshall Richard 
Published: February 2023

On November 25, 2022, Rear Admiral Richard Kelshall (Rtd), presented his closing remarks for this year’s West Coast Security Conference. The key points discussed were the current weaponization of mis/disinformation and suggestions to combat against it, eliminating information silos, and turning towards Caribbean nations regarding intelligence sharing.

Received: 2022-12-21Revised: 2022-12-29
The Effects of a Web-Based Intervention to Reduce Alcohol Consumption Among Middle-Aged Women: Protocol for a Randomized Controlled Trial
Authors: Miller Mia , Wright Cassandra , Kuntsche Emmanuel , Kuntsche Sandra 
Published: February 2023

Background
In the last decade, alcohol consumption among middle-aged women (40-65 years old) in Australia increased, despite declines in overall population consumption. Web-based, brief interventions are promising for reducing alcohol consumption, with efficacy shown in a wide range of populations. However, no published interventions have been designed specifically for and tested with middle-aged women.

Objective
This study aims to design and implement a web-based intervention intended to reduce alcohol consumption among middle-aged women.

Methods
The study is a 3-arm randomized controlled trial with a web-based intervention plus ecological momentary assessment (EMA) group compared to an EMA-only and a pre-post only control group. The study is aimed at middle-aged women, defined as women aged between 40 and 65 years, who consume alcohol at least weekly or who have consumed 4 or more drinks on 1 occasion in the last month. The intervention aims to reduce alcohol consumption through 4 modules that provide information on the health impacts of alcohol, mindfulness, social influences, and alcohol marketing. Intervention participants will also fill out biweekly EMA assessments. The comparators are EMA-only and pre-post control only. The primary outcome is alcohol consumption at 8 weeks compared between groups. Secondary outcomes are awareness of alcohol-related harms, readiness to change alcohol consumption, health status, mental health, and social support.

Results
Ethics approval for this project was received on September 11, 2019. The trial was registered on August 14, 2020. Recruitment has commenced, and the expected results will be available in 2022.

Conclusions
This web-based intervention aims to reduce alcohol consumption among middle-aged women, a currently understudied cohort in alcohol research.

Trial Registration
Australia New Zealand Clinical Trials Registry (ANZCTR) ACTRN12620000814976; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12620000814976

International Registered Report Identifier (IRRID)
DERR1-10.2196/34842
Factors Influencing Community Participation in Internet Interventions Compared With Research Trials: Observational Study in a Nationally Representative Adult Cohort
Authors: Batterham Philip , Gulliver Amelia , Sunderland Matthew , Farrer Louise , Kay-Lambkin Frances , Trias Angelica , Calear Alison 
Published: February 2023

Background
Digital mental health (DMH) programs can be effective in treating and preventing mental health problems. However, community engagement with these programs can be poor. Understanding the barriers and enablers of DMH program use may assist in identifying ways to increase the uptake of these programs, which have the potential to provide broad-scale prevention and treatment in the community.

Objective
In this study, we aimed to identify and compare factors that may influence participation in DMH programs in practice and research trials, identify any respondent characteristics that are associated with these factors, and assess the relationship between intentions to use DMH programs and actual uptake.

Methods
Australian adults aged ≥18 years were recruited from market research panels to participate in the study. The sample was representative of the Australian adult population based on age, gender, and location. Participants completed a cross-sectional web-based survey assessing demographic characteristics, mental health symptom measures, attitudes and use of DMH programs in practice and in research studies, and the factors influencing their use in both settings.

Results
Across both research and practice, trust in the organization delivering the service or trial was the top-ranked factor influencing participation, followed by anonymity or privacy and adequate information. There was little variation in rankings across demographic groups, including intentions to use DMH programs or mental health status. Intentions to use DMH programs were a strong predictor of both current (odds ratio 2.50, 99% CI 1.41-4.43; P<.001) and past (odds ratio 2.98, 99% CI 1.71-5.19; P<.001) use behaviors.

Conclusions
Efforts to increase the uptake of DMH programs or participation in research trials should focus on clearly communicating the following to users: the legitimacy of the organization delivering the program, security and use of participant data, and effectiveness of DMH programs.