bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI PENGEMBANGAN PANTAI SEBAGAI DESTINASI EKOWISATA
Authors: Sarjono  
Published: January 2023

The aim of this reseach was to find the right strategy to develop the beach of Sipelot by taking into account the potential of tourism supply and demand. This research uses descriptive qualitative method, with observation, interviews, questionnaires as instruments for collecting data and analyzing data using SWOT. The results of the IFAS and EFAS analysis the Sipelot ecotourism coastal in quadrant I, which means growth strategy, meaning that Sipelot beach ecotourism will provide benefits if developed sustainably. Based on the SWOT matrix analysis, the strategy formulation to develop Sipelot beach ecotourism is 1. tourism product development strategy, 2. marketing and promotion strategy, 3. accessibility development strategy, 4. development strategy and improvement of public facilities and 5. business development strategies.
Inter humum caelumque: relatos y ajuares. El patrimonio cultural del pueblo vacceo a través del Programa Pintia de Innovación Educativa del Colegio Safa-Grial.
Authors: Castro Pablo de 
Published: January 2023

El Programa Pintia de Innovación Educativa es un proyecto surgido de la colaboración entre el Centro de Estudios Vacceos Federico Wattenberg de la Universidad de Valladolid y el Colegio Safa-Grial, a través del cual se persigue estudiar y visibilizar la cultura vaccea, presente en el yacimiento de Pintia (Padilla de Duero, Valladolid), a través de un complejo conjunto de actividades educativas.
En este artículo se aborda el estudio de aquellas que componen el corpus Inter humum caelumque, cuya finalidad es la recuperación del patrimonio inmaterial vacceo mediante procesos de identización.
La metodología utilizada para ello se apoya en un relato autoetnográfico del proyecto, que proce-de del estudio de caso presentado por el autor en su tesis doctoral: Cartografía autoetnográfica de una genealogía de programas de educación patrimonial desde la perspectiva del aprendizaje basado en proyectos y la investigación acción (de Castro, 2016).
Como conclusiones destacan la validación de los procesos identitarios para abordar el estudio de contenidos curriculares en Educación Secundaria y la capacidad de estos para producir aprendizajes significativos a través de la metodología de investigación basada en las artes.
Educación patrimonial y redes sociales. De la investigación a la acción: El proyecto Educación Patrimonial
Authors: Maldonado Esteras Stella 
Published: January 2023

Los medios de comunicación social 2.0 han supuesto un viraje en muchos procesos de desarrollo, de comunicarnos, de relacionarnos. A día de hoy, no utilizamos las tecnologías digitales para obtener única y exclusivamente información. La web 2.0 nos ha brindado una nueva sociedad, no sólo de la información y el conocimiento, sino también del diálogo y la opinión abierta, los aprendizajes múltiples, la compartición y la creación de redes que no escapan a ninguna disciplina. El patrimonio es una de estas disciplinas presentes en las redes sociales.
Partiendo de dos momentos o etapas de investigación, hemos ido analizando la presencia del patrimonio en estos contextos, en busca de ejemplos de educación patrimonial. Y hemos dado con modelos de comunicación del patrimonio que se adecuan a los nuevos lenguajes. Nuestra intención on estos estudios era ir construyendo, partiendo de la realidad existente, una acción educomunicativa y metodológica con base en la investigación-acción como práctica educativa y evaluativa. De esta forma surge Educación Patrimonial, en desarrollo actualmente, con la motivación de trabajar con diferentes patrimonios, estableciendo vínculos entre éstos y las personas.
Wind Speed Thresholds for Adjusting Conventional Design Criteria for the Ventilated Improved Pit Latrine without Compromising Odour Control
Authors: Obeng Peter Appiah , Awere Eric , Obeng Panin Asirifua , Oteng-Peprah Michael , Barnie Samuel 
Published: January 2023

Aims: The objective of this paper is to re-evaluate the wind speed threshold at which the 100 mm polyvinyl chloride (PVC) vent pipe may be used without compromising the ventilation rate required for effective odor control in a ventilated improved pit (VIP) latrine. The paper also sought to investigate the chances of leveraging upon high wind speeds to grant user preferences for multiple windows and installation of insect screens, which are conventionally forbidden.
Study Design: A comparative experimental design was carried out in a VIP latrine with internal cubicle dimensions of 1.2 m x 1.5 m built over a pit of cross-section 1.2 m x 2.5 m and depth of 3.0 m which was fitted with a 100 mm PVC vent pipe.
Place and Duration of Study: The experimental setup was located on the compound of a public basic school in Prampram, a peri-urban coastal community in Southern Ghana. The setup was monitored for twelve hours a day (5 am to 5 pm) for twelve days.
Methodology: The experimental setups comprised of four designs of the VIP latrine: single-window and multi-window designs each with and without insect screen in the window. The ventilation rate in each modified design was monitored simultaneously with the external wind speed.
Results: The results of the study indicate that the 100 mm PVC vent pipe could attain the recommended ventilation rate of 20 m3/h at an average wind speed as slow as 1.5 m/s as compared to the 3 m/s previously suggested. The influence of wind speed on the ventilation rate is insignificant at wind speed variations not exceeding 0.5 m/s when the 100 mm PVC vent pipe is used.
Conclusion: At an average wind speed of 1.5 m/s, either the multiple-window design or insect screen used in combination with the 100 mm PVC vent pipe could attain the recommended ventilation rate and should not be outrightly forbidden. However, a wind speed threshold of 2.5 m/s is required for the adoption of the multi-window design with insect screens when the 100 mm PVC vent pipe is used.
Sulfur Mismatch Substitution in Layered Double Hydroxides as Efficient Oxygen Electrocatalysts for Flexible Zinc–Air Batteries
Authors: Han Xiaotong , Li Nannan , Baik Jae Sung , Xiong Peixun , Kang Yingbo , Dou Qingyun , Liu Qing , Lee Jin Yong , Kim Chul Sung , Park Ho Seok 
Published: January 2023

AbstractAlthough layered double hydroxides (LDHs) are extensively investigated for oxygen electrocatalysis, their development is hampered by their limited active sites and sluggish reaction kinetics. Here, sulfur mismatch substitution of NiFe–LDH (S–LDH) is demonstrated, which are in‐situ deposited on nitrogen‐doped graphene (S–LDH/NG). This atomic‐level sulfur incorporation leads to the construction of the tailored topological microstructure and the modulated electronic structure for the improved catalytic activity and durability of bifunctional electrocatalysts. The combined computational and experimental results clarify that the electron transfer between the sulfur anion and Fe3+ generates the high‐valence Fe4+ species, while the mismatch substitution of the sulfur anion induces the metallic conductivity, an increased carrier density, and the reduced reaction barrier. Consequently, the as‐fabricated Zn–air battery achieves a high power density of 165 mW cm‐2, a large energy density of 772 Wh kgZn‐1 at 5 mA cm‐2, and long cycle stability for 120 h, demonstrating its real‐life operation.
Synergistic Solvation of Anion: An Effective Strategy toward Economical High‐Performance Dual‐Ion Battery
Authors: Wang Boyu , Huang Yuhao , Wang Ying , Wang Hongyu 
Published: January 2023

AbstractThe solvation structure of anion plays a crucial role in determining the performance of dual‐ion batteries using graphite‐positive electrodes. In past research on dual‐ion batteries, the design criteria of electrolyte solutions were largely based on the traditional relationship between solvents and additives. Here, a distinctive synergistic solvation strategy is proposed for the design of electrolyte solutions. Despite some solvents performing poorly or even failing to operate when they are used alone for electrolyte solutions, an unexpected improved performance appears when they are combined based on their characteristic moieties. Based on the synergistic solvation strategy, an economical electrolyte solution system (LiPF6‐methyl acetate/diethyl carbonate) is successfully designed. The intercalation behavior of the solvated anion from this solution into the graphite electrode is investigated by conventional electrochemical tests, in situ electrochemical characterizations and theoretical calculations. A proof‐of‐concept dual‐ion battery based on this electrolyte solution delivers a discharge capacity of 100.08 mAh g−1 and ≈4.67 V medium discharge voltage at 10C (1 A g−1), along with 85.35% capacity retention after 1000 cycles at 5C. Moreover, this battery exhibits 93.8% of its room‐temperature capacity at −20 °C and can even work at −70 °C. Synergistic solvation offers a novel approach to design electrolyte solutions for dual‐ion batteries.
Stress Induced Color and Pattern for Information Coding
Authors: Bai Jing , Zhang Luzhi , Shi Zixing , Jiang Xuesong 
Published: January 2023

AbstractOn the process of deforming polymer, its morphologies can be vividly observed and reflected via the internal stress distribution under the polarized light due to its special stretched birefringence, which gives a new way to store and read information. Inspired by this vivid character, a novel crosslinked polyurethane (PU) is designed and used as matrix for coding information, in which aluminum acetylacetonate works as the crosslinker to form dynamical crosslinked structure with coordinated bonds. By tailoring these two bonds via a region‐selective regulation, the information can be written in the crosslinked PU. Only under the polarized light, the coded information can be read as stress induced color on the deformed state. After its recovery, 2D pattern can be simultaneously formed on the surface of the film. Therefore, the information is expressed in multiple channels. Thanks to the dynamic character, the information can be also erased and rewritten. Therefore, it is a new method for information coding with a high security, which has a wide range of potential applications in data storage, anticounterfeiting labeling, information conversion, and other areas.
Plant‐Derived Vesicle‐Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future
Authors: Feng Junjie , Xiu Qi , Huang Yiyao , Troyer Zach , Li Bo , Zheng Lei 
Published: January 2023

AbstractExtracellular vesicles (EVs) are heterogeneous, phospholipid bilayer‐enclosed biological particles that regulate cell communication by molecular cargo delivery and surface signaling. EVs are secreted by almost all living cells, including plant cells. Plant‐derived vesicle‐like nanoparticles (PDVLNs) is a generic term referring to vesicle‐like nanostructure particles isolated from plants. Their low immunogenicity and wide availability make PDVLNs safer and more economical to be developed as therapeutic agents and drug carriers. Accumulating evidence indicates the key roles of PDVLNs in regulating interkingdom crosstalk between humans and plants. PDVLNs are capable of entering the human‐body systemand delivering effector molecules to cells that modulate cell‐signaling pathways. PDVLNs released by or obtained from plants thus have great influenceon human health and diseases. In this review, the biogenesis, detailed preparation methods, various physical and biochemical characteristics, biosafety, and preservation of PDVLNs are introduced, along with how these characteristics pertain to their biosafety and preservability. The potential applications of PDVLNs on different plant and mammalian diseases and PDVLN research standardization are then systematically discussed.
Recent Progress of Hollow Carbon Nanocages: General Design Fundamentals and Diversified Electrochemical Applications
Authors: Li Zesheng , Li Bolin , Yu Changlin , Wang Hongqiang , Li Qingyu 
Published: January 2023

AbstractHollow carbon nanocages (HCNCs) consisting of sp2 carbon shells featured by a hollow interior cavity with defective microchannels (or customized mesopores) across the carbon shells, high specific surface area, and tunable electronic structure, are quilt different from the other nanocarbons such as carbon nanotubes and graphene. These structural and morphological characteristics make HCNCs a new platform for advanced electrochemical energy storage and conversion. This review focuses on the controllable preparation, structural regulation, and modification of HCNCs, as well as their electrochemical functions and applications as energy storage materials and electrocatalytic conversion materials. The metal single atoms‐functionalized structures and electrochemical properties of HCNCs are summarized systematically and deeply. The research challenges and trends are also envisaged for deepening and extending the study and application of this hollow carbon material. The development of multifunctional carbon‐based composite nanocages provides a new idea and method for improving the energy density, power density, and volume performance of electrochemical energy storage and conversion devices.
Assessment of renal outcome following therapy in monoclonal immunoglobulin deposition disease: Emphasizing the need for a consensus approach
Authors: Pianko Matthew J. , Tiutan Timothy , Derkach Andriy , Flynn Jessica , Salvatore Steven P. , Jaffer‐Sathick Insara , Rossi Adriana C. , Lahoud Oscar , Hultcrantz Malin , Shah Urvi A. , Maclachlan Kylee , Chung David J. , Shah Gunjan L. , Landau Heather J. , Korde Neha , Mailankody Sham , Lesokhin Alexander M. , Tan Carlyn , Scordo Michael , Jaimes Edgar A. , Giralt Sergio A. , Usmani Saad , Hassoun Hani 
Published: January 2023

AbstractMonoclonal immunoglobulin deposition disease (MIDD), often associated with plasma cell dyscrasias, predominantly affects the kidneys. In this disease, hematologic response (HR) to treatment can be reliably assessed by International Myeloma Working Group (IMWG) consensus criteria, while uniform criteria for assessing renal response are lacking. We report a retrospective analysis of renal outcomes among 34 patients with MIDD. With most patients treated with bortezomib and autologous stem cell transplantation, 26 of 28 (94%) achieved very good partial HR or better. We demonstrate that both IMWG (based on estimated glomerular filtration rate, eGFR) and amyloid (based on proteinuria) criteria are needed to capture renal response: among 28 evaluable patients, 6 (21%) had isolated proteinuria, while 13 (46%) had isolated decreased eGFR. Using both criteria, which were concordant in patients with both decreased eGFR and proteinuria, 22 of 28 patients (79%) achieved a renal response, including 2 of 7 discontinuing dialyses. All 6 patients (100%) with isolated proteinuria and 7 of 13 (54%) with isolated decreased eGFR achieved renal response, suggesting that isolated proteinuria is an early manifestation of MIDD associated with reversible renal damage. Baseline eGFR predicted renal response (p = .02 by quartile) and survival (p = .02), while HR (CR vs. non‐CR) did not, probably because of high HR rate. With a median follow‐up of 110 months, the median overall survival was 136 months (95% CI: 79–NR) and median renal survival had not been reached. Prospective studies using uniform renal response criteria are needed to optimize the management of MIDD.
Survival trends in young patients with Waldenström macroglobulinemia: Over five decades of experience
Authors: Chohan Karan L. , Paludo Jonas , Vallumsetla Nishanth , Larson Dirk , King Rebecca L. , He Rong , Gonsalves Wilson , Inwards David , Witzig Thomas E. , Swaika Abhisek , Jain Tania , Leung Nelson , Ailawadhi Sikander , Reeder Craig B. , Lacy Martha Q. , Rajkumar S. Vincent , Kumar Shaji , Kyle Robert A. , Gertz Morie A. , Ansell Stephen M. , Kapoor Prashant 
Published: January 2023

AbstractWaldenström macroglobulinemia (WM) is a rare, indolent lymphoma, that predominately affects the elderly. We report the outcomes of young WM patients, evaluated over five decades, compared to their older counterparts, matched for the time of diagnosis. Between January 1, 1960 and October 31, 2013, 140 (11.8%) WM patients were ≤50 years of age at diagnosis in our database, and their estimated 10‐year overall survival (OS) was 74%, with death attributable to WM in a higher proportion of patients compared to their older (≥65 years) counterparts (91% vs. 58%, p = .0001). Young patients were grouped into three cohorts based on the timing of the initiation of therapy: Group 1 (1960–1977, n = 12), Group 2 (1978–1995, n = 48), and Group 3 (1996–2013, n = 74). Among young patients, there was no disease‐specific survival (DSS) difference across the three periods, [median DSS at 13 years (95% CI 5–23), 16 years (95% CI 14–22), and 15 years (95% CI 10‐NR; p = .41), respectively]. However, DSS for the older cohort incrementally improved (Group 1, median 5.2 years, Group 2: 9.6 years, Group 3: 12 years; p = .05) over these periods. The estimated average years‐of‐life lost for the young cohort was 11.2 years from diagnosis, based on the expected survival for a normal age‐ and sex‐matched population. Despite a protracted disease course, nearly all young patients succumb to their disease. In contrast to the improved survival of the elderly patient population, the evolving treatment strategies in WM have not impacted the outcome of young patients; however, the impact of Bruton tyrosine kinase inhibitors on this unique patient population remains to be determined.
Multisite ALLFTD study modeling progressive empathy loss from the earliest stages of behavioral variant frontotemporal dementia
Authors: Toller Gianina , Cobigo Yann , Callahan Patrick , Appleby Brian S. , Brushaber Danielle , Domoto‐Reilly Kimiko , Forsberg Leah K. , Ghoshal Nupur , Graff‐Radford Jonathan , Graff‐Radford Neil R. , Grossman Murray , Heuer Hilary W. , Kornak John , Kremers Walter , Lapid Maria I. , Leger Gabriel , Litvan Irene , Mackenzie Ian R. , Pascual Maria B. , Ramos Eliana M. , Rascovsky Katya , Rojas Julio C. , Staffaroni Adam M. , Tartaglia Maria C. , Toga Arthur , Weintraub Sandra , Wszolek Zbigniew K. , Boeve Brad F. , Boxer Adam L. , Rosen Howard J. , Rankin Katherine P. ,   the ALLFTD consortium
Published: January 2023

AbstractIntroductionEmpathy relies on fronto‐cingular and temporal networks that are selectively vulnerable in behavioral variant frontotemporal dementia (bvFTD). This study modeled when in the disease process empathy changes begin, and how they progress.MethodsFour hundred thirty‐one individuals with asymptomatic genetic FTD (n = 114), genetic and sporadic bvFTD (n = 317), and 163 asymptomatic non‐carrier controls were enrolled. In sub‐samples, we investigated empathy measured by the informant‐based Interpersonal Reactivity Index (IRI) at each disease stage and over time (n = 91), and its correspondence to underlying atrophy (n = 51).ResultsEmpathic concern (estimate = 4.38, 95% confidence interval [CI] = 2.79, 5.97; p < 0.001) and perspective taking (estimate = 5.64, 95% CI = 3.81, 7.48; p < 0.001) scores declined between the asymptomatic and very mild symptomatic stages regardless of pathogenic variant status. More rapid loss of empathy corresponded with subcortical atrophy.DiscussionLoss of empathy is an early and progressive symptom of bvFTD that is measurable by IRI informant ratings and can be used to monitor behavior in neuropsychiatry practice and treatment trials.
Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools
Authors: Williams Sierra J. , Gewing‐Mullins Jordan A. , Lieberman Whitney K. , Kolbaba‐Kartchner Bethany , Iqbal Reema , Burgess Hana M. , Colee Clair M. , Ornelas Marya Y. , Reid‐McLaughlin Edison S. , Mills Jeremy H. , Prescher Jennifer A. , Leconte Aaron M. 
Published: January 2023

AbstractEngineered luciferase‐luciferin pairs have expanded the number of cellular targets that can be visualized in tandem. While light production relies on selective processing of synthetic luciferins by mutant luciferases, little is known about the origin of selectivity. The development of new and improved pairs requires a better understanding of the structure−function relationship of bioluminescent probes. In this work, we report a biochemical approach to assessing and optimizing two popular bioluminescent pairs: Cashew/d‐luc and Pecan/4′‐BrLuc. Single mutants derived from Cashew and Pecan revealed key residues for selectivity and thermal stability. Stability was further improved through a rational addition of beneficial residues. In addition to providing increased stability, the known stabilizing mutations surprisingly also improved selectivity. The resultant improved pair of luciferases are >100‐fold selective for their respective substrates and highly thermally stable. Collectively, this work highlights the importance of mechanistic insight for improving bioluminescent pairs and provides significantly improved Cashew and Pecan enzymes which should be immediately suitable for multicomponent imaging applications.
Synthesis of Isomeric Tb3+–Phthalocyanine Double‐Decker Complexes Depending on the Difference in the Direction of Coordination Plane and Their Magnetic Properties
Authors: Yamada Yasuyuki , Nakajima Hiroaki , Kobayashi Chisa , Shuku Yoshiaki , Awaga Kunio , Akine Shigehisa , Tanaka Kentaro 
Published: January 2023

AbstractInvited for the cover of this issue are Kentaro Tanaka at Nagoya University and co‐workers. The image depicts three isomers of a terbium(III) phthalocyanine double‐decker complex made from C4h symmetrically substituted phthalocyanines and their magnetic properties. Read the full text of the article at 10.1002/chem.202203272.
Higher‐Order Cycloaddition Reactions for the Construction of Polycyclic Aromatic and Polycyclic Heteroaromatic Compounds
Authors: Bitsch René S. , Jessen Nicolaj Inunnguaq , Jørgensen Karl Anker 
Published: January 2023

AbstractCycloadditions are an important class of reactions in materials science for the construction of polycyclic aromatic and polycyclic heteroaromatic compounds. Recently, cycloadditions have been expanded beyond the “classical” group of cycloadditions involving six π‐electrons, and it is now possible to control cycloadditions for an extended number of π‐electrons by applying organocatalysis. This novel field of cycloadditions–termed higher‐order cycloadditions–allows new synthetic methodologies to construct polycyclic carbo‐ and heteroaromatic compounds in two or three dimensions. This concept presents higher‐order cycloadditions as a method for accessing two‐ and three‐dimensional azulenes and cyclazines, as well as three dimensional indenes, as polycyclic aromatic and polycyclic heteroaromatic compounds.