bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Perbandingan Curah Hujan dan Debit Banjir di Das Citanduy Hulu Bendungan Leuwikeris
Authors: Permana Sulwan , Dwiyanto Bambang Haidar 
Published: June 2023

Sungai Citanduy yang berada di Wilayah Priangan Timur di Provinsi Jawa Barat, akhir-akhir ini pada musim penghujan curah hujan yang terjadi sangat tinggi, durasi hujan yang lama, dan distribusi hujan yang tidak merata menimbulkan permasalahan banjir dibeberapa tempat khususnya di daerah Kabupaten Tasikmalaya, Kabupaten Ciamis, Kota Banjar, dan Kabupaten Pangandaran. Di bagian hulu sungai kerap terjadi banjir dan longsor seperti didaerah Tanjungsari Kecamatan Sukaresik. Sedangkan di bagian hilir, warga mengalami banjir yang disebabkan meluapnya Sungai Citanduy seperti didaerah Sindangreja, Wanareja, Lakbok dan sekitarnya. Penelitian ini bertujuan untuk memperoleh nilai perbandingan intensitas curah hujan di kawasan DAS Citanduy hulu sampai Bendungan Leuwikeris dengan menggunakan Metode Talbot, Sherman, dan Ishiguro, sedangkan debit banjir menggunakan metode Nakayasu. Berdasarkan hasil analisis perhitungan perbandingan intensitas curah hujan, bahwa Metode Ishiguro merupakan metode yang paling efektif digunakan dalam menghitung intensitas curah hujan dengan nilai sebesar 938,82 mm/jam pada tahun 2008-2014 dan pada tahun 2015-2021 sebesar 1126,74 mm/jam. Perbandingan debit banjir untuk periode ulang 2 tahun diperoleh hasil sebesar 193,94 m3/detik pada tahun 2008-2014 dan pada tahun 2015-2021 didapatkan hasil sebesar 232,77 m3/detik, maka dari hasil perhitungan perbandingan debit banjir bisa disimpulkan bahwa debit banjir pada tahun 2015-2021 lebih besar dari pada debit banjir pada tahun 2008-2014.
The role of diet in bowel cleansing for colonoscopy (results of prospective observation study). Prospective observations study
Authors: Galyaev A. V. , Surovegin E. S. , Likutov A. A. , Sushkov O. I. , Vaganov Yu. E. , Voskanyan A. S. , Merkulova E. S. 
Published: June 2023

AIM: to evaluate the impact of dietary compliance in bowel cleansing for colonoscopy on the quality of the procedure.PATIENTS AND METHODS: one thousand patients who scheduled for diagnostic colonoscopy were included in the prospective observation study. The quality of bowel preparation was assessed using the Boston scale. Neoplasms were detected and endoscopically evaluated. The optical verification of tumors was used to calculate the indicators of identified adenomas and polyps (ADR and PDR).RESULTS: the quality of bowel cleansing by the Boston Scale was 6 (6; 8) points. One hundred eight (19.8%) patients did not follow the recommended diet. Poor preparation, which did not allow a total colonoscopy was found in 91 (9,1%) cases. The ADR was 37.4%, PDR — 43.4%. Logistic regression analysis showed that the noncompliance for diet recommendation was the only one significantly negative factor associated whit inadequate bowel cleansing.CONCLUSION: the leading factor worsening the quality of bowel cleansing was non-compliance with the prescribed diet before the colonoscopy.
An integrated weed management approach in tomato using soil steaming, mulching, and winter cover crops
Authors: de Oliveira Tabata Raissa , Serafim Augusto Dubou , Breland Brenton , Miller Alyssa , Beneton Karina , Singh Varsha , Segbefia Worlanyo , Argenta Josiane C. , Broderick Shaun R. , Tseng Te Ming 
Published: June 2023

One of the most significant yield losses in tomato (Solanum lycopersicum L.) is due to weeds. Yellow and purple nutsedge, large crabgrass, and Palmer amaranth are the most troublesome weed species in tomato production throughout the southeastern United States. This study aimed to determine the impact of soil steaming, plastic mulching, and cover crops on weed suppression, tomato height, and fruit yield. The cover crops used were hairy vetch (Vicia villosa), crimson clover (Trifolium incarnatum), and cereal rye (Secale cereale). The study was conducted at the Mississippi State University Truck Crops Experiment Station in Crystal Springs, Mississippi, USA. The experiment used a completely randomized block design with three fall cover crop treatments, including fallow, and each was replicated three times and repeated in two years. Each plot was broadcasted with a mixture of yellow nutsedge (Cyperus esculentus L.), large crabgrass (Digitaria sanguinalis L.), barnyardgrass (Echinochloa crus-galli), and Palmer amaranth [Amaranthus palmeri (S.) Watson] at a density of 20 plants m-2 for each weed species. Two days after sowing the weed seeds, the soil surface was steamed according to its assigned treatment until it reached 61°C for either 0, 5, or 20 min. After steaming, drip irrigation tubing was laid on each row, and covered by black, 0.0254-mm plastic mulch. Data were recorded in both years, including weed cover, plant height, and fruit yield. The lowest weed cover was observed at 5 min of soil steaming in mulched treatment, and the highest cover was noted at 0 min of soil steaming in the absence of mulching. Yellow nutsedge was the dominant weed species, even under steam and mulch treatments. The use of cover crops did not show a difference compared to fallow treatments. However, hairy vetch showed the lowest weed cover, followed by crimson clover. Tomato plants in steamed soil were up to 13 cm taller than those in unsteamed soils. Additionally, steaming at 5 or 20 min in combination with plastic mulch increased the marketable and cull yield. Soil steaming and mulching increased tomato plant height and yield while decreasing weed population and can, therefore, be effectively incorporated into an integrated weed management program in tomato.
Term alpaca placenta glycosylation profile and its correlation with pregnancy maintenance and fetal survival
Authors: Navarrete Zamora Miluska Beatriz , Silva Thamires Santos da , Silva Mônica Duarte da , Almeida Gustavo Henrique Doná Rodrigues , Silva-Júnior Leandro Norberto da , Horvath-Pereira Bianca de Oliveira , Baracho Hill Amanda Trindade , Acuña Francisco , Carreira Ana Claudia Oliveira , Barreto Rodrigo da Silva Nunes , Sato Alberto Sato , Miglino Maria Angélica 
Published: June 2023

Alpaca is a South American camelid, particularly present in Peruvian highlands, where oxygen concentration and atmospheric pressure are very low. Due to this fact, gestational physiology has adapted to preserve the conceptus’ and mother’s health. In this context, several cellular and molecular features play an essential role during and at the end of gestation. Structural carbohydrates act on maternal–fetal communication, recognize exogenous molecules, and contribute to placental barrier selectivity. Therefore, this study aimed to characterize the structural carbohydrate profiles that are present in the term alpaca placenta, kept in their natural habitat of around 4,000 m height. For this propose, 12 term alpaca placentas were collected, and the material was obtained at the time of birth from camelids raised naturally in the Peruvian highlands, in the Cusco region. All placenta samples were processed for histological analysis. A lectin histochemical investigation was performed using 13 biotinylated lectins, allowing us to determine the location of carbohydrates and their intensity on a semi-quantitative scale. Our results demonstrated that during term gestation, the epitheliochorial alpaca placenta shows a high presence of carbohydrates, particularly glucose, α-linked mannose, N-acetylglucosamine β (GlcNAc), galactose (αGal), and N-acetylgalactosamine α (GalNAc), present in the trophoblast, amnion epithelium, and mesenchyme, as well as the presence of sialic acid residues and low affinity for fucose. In fetal blood capillaries, the presence of bi- and tri-antennary complex structures and α-linked mannose was predominated. In conclusion, we characterized the glycosylation profile in the term alpaca placenta. Based on our data, compared to those reported in the bibliography, we suggest that these carbohydrates could participate in the labor of these animals that survive in Peruvian extreme environments.
Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease
Authors: Li Kangbo , Dai Mengjun , Sacirovic Mesud , Zemmrich Claudia , Pagonas Nikolaos , Ritter Oliver , Grisk Olaf , Lubomirov Lubomir T. , Lauxmann Martin A. , Bramlage Peter , Persson Anja Bondke , Buschmann Eva , Buschmann Ivo , Hillmeister Philipp 
Published: June 2023

BackgroundWe investigated the association between leukocyte telomere length, mitochondrial DNA copy number, and endothelial function in patients with aging-related cardiovascular disease (CVD).MethodsIn total 430 patients with CVD and healthy persons were enrolled in the current study. Peripheral blood was drawn by routine venipuncture procedure. Plasma and peripheral blood mononuclear cells (PBMCs) were collected. Cell-free genomic DNA (cfDNA) and leukocytic genomic DNA (leuDNA) were extracted from plasma and PBMCs, respectively. Relative telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) were analyzed using quantitative polymerase chain reaction. Endothelial function was evaluated by measuring flow-mediated dilation (FMD). The correlation between TL of cfDNA (cf-TL), mtDNA-CN of cfDNA (cf-mtDNA), TL of leuDNA (leu-TL), mtDNA-CN of leuDNA (leu-mtDNA), age, and FMD were analyzed based on Spearman's rank correlation. The association between cf-TL, cf-mtDNA, leu-TL, leu-mtDNA, age, gender, and FMD were explored using multiple linear regression analysis.Resultscf-TL positively correlated with cf-mtDNA (r = 0.1834, P = 0.0273), and leu-TL positively correlated with leu-mtDNA (r = 0.1244, P = 0.0109). In addition, both leu-TL (r = 0.1489, P = 0.0022) and leu-mtDNA (r = 0.1929, P &lt; 0.0001) positively correlated with FMD. In a multiple linear regression analysis model, both leu-TL (β = 0.229, P = 0.002) and leu-mtDNA (β = 0.198, P = 0.008) were positively associated with FMD. In contrast, age was inversely associated with FMD (β = −0.426, P &lt; 0.0001).ConclusionTL positively correlates mtDNA-CN in both cfDNA and leuDNA. leu-TL and leu-mtDNA can be regarded as novel biomarkers of endothelial dysfunction.
Analyzing the effect of the COVID-19 vaccine on Parkinson’s disease symptoms
Authors: Sabat Revati , Dayton Orrin L. , Agarwal Amit , Vedam-Mai Vinata 
Published: June 2023

BackgroundParkinson’s Disease (PD) is one of the most common neurodegenerative diseases. PD has recently received more attention by researchers in the midst of the COVID-19 pandemic.ObjectiveYet to be researched is the effect of the COVID-19 vaccines on PD patients. Several PD patients are still hesitant to the vaccine due to this unaddressed fear. The purpose of this study is to address this gap.MethodsSurveys were administered to PD patients 50 years and older at UF Fixel Institute who received at least one dose of the COVID-19 vaccine. Survey questions included patients’ severity of PD symptoms before and after the vaccine and extent of worsening PD symptoms post-vaccination. After three weeks of collecting responses, the data was analyzed.Results34 respondents were eligible for data consideration because they fell within the age range being studied. A total of 14 respondents out of 34 (41%, p=0. 0001) reported that their PD symptoms worsened after the COVID-19 vaccine to some extent.ConclusionThere was strong evidence of worsening of PD symptoms post COVID-19 vaccination, however it was mostly mild and limited to a couple of days. The worsening had statistically significant moderate positive correlation with vaccine hesitancy and post-vaccine general side effects. A possible causative mechanism of PD symptom worsening using existing scientific knowledge would be stress and anxiety associated with vaccine hesitancy and the extent of post-vaccine general side effects (fever, chills, pain), likely via simulating a mild systemic infection/inflammation the latter already established causes of PD symptom worsening.
Efficacy and safety of ultra-short wave diathermy on COVID-19 pneumonia: a pioneering study
Authors: Huang Liangjiang , Li Qian , Shah Sayed Zulfiqar Ali , Nasb Mohammad , Ali Iftikhar , Chen Bin , Xie Lingfeng , Chen Hong 
Published: June 2023

BackgroundThe ultra-short wave diathermy (USWD) is widely used to ameliorate inflammation of bacterial pneumonia, however, for COVID-19 pneumonia, USWD still needs to be verified. This study aimed to investigate the efficacy and safety of USWD in COVID-19 pneumonia patients.MethodsThis was a single-center, evaluator-blinded, randomized controlled trial. Moderate and severe COVID-19 patients were recruited between 18 February and 20 April 2020. Participants were randomly allocated to receive USWD + standard medical treatment (USWD group) or standard medical treatment alone (control group). The negative conversion rate of SARS-CoV-2 and Systemic Inflammatory Response Scale (SIRS) on days 7, 14, 21, and 28 were assessed as primary outcomes. Secondary outcomes included time to clinical recovery, the 7-point ordinal scale, and adverse events.ResultsFifty patients were randomized (USWD, 25; control, 25), which included 22 males (44.0%) and 28 females (56.0%) with a mean (SD) age of 53 ± 10.69. The rates of SARS-CoV-2 negative conversion on day 7 (p = 0.066), day 14 (p = 0.239), day 21 (p = 0.269), and day 28 (p = 0.490) were insignificant. However, systemic inflammation by SIRS was ameliorated with significance on day 7 (p = 0.030), day 14 (p = 0.002), day 21 (p = 0.003), and day 28 (p = 0.011). Time to clinical recovery (USWD 36.84 ± 9.93 vs. control 43.56 ± 12.15, p = 0.037) was significantly shortened with a between-group difference of 6.72 ± 3.14 days. 7-point ordinal scale on days 21 and 28 showed significance (p = 0.002, 0.003), whereas the difference on days 7 and 14 was insignificant (p = 0.524, 0.108). In addition, artificial intelligence-assisted CT analysis showed a greater decrease in the infection volume in the USWD group, without significant between-group differences. No treatment-associated adverse events or worsening of pulmonary fibrosis were observed in either group.ConclusionAmong patients with moderate and severe COVID-19 pneumonia, USWD added to standard medical treatment could ameliorate systemic inflammation and shorten the duration of hospitalization without causing any adverse effects.Clinical Trial Registration: chictr.org.cn, identifier ChiCTR2000029972.
Hepatitis E Virus Persistence and/or Replication in the Peripheral Blood Mononuclear Cells of Acute HEV-Infected Patients
Authors: Sayed Ibrahim M. , Abd Elhameed Zeinab A. , Abd El-Kareem Doaa M. , Abdel-Malek Mohamed A. Y. , Ali Mohamed E. , Ibrahim Maggie A. , Sayed Ayat Abdel-Rahman , Khalaf Khaled Abo bakr , Abdel-Wahid Lobna , El-Mokhtar Mohamed A. 
Published: June 2023

Graphical AbstractFlow of the study design: Blood collected from acute HEV patients were fractiontated into plasma and PBMCs. Plasma was used for cytokine assay. RNA was extracted from the PBMCs and used for determinaton of viral load, detection of (+) and (−) HEV RNA strands, and gene expression assay.
Pre-diagnostic prognostic value of leukocytes count and neutrophil-to-lymphocyte ratio in patients who develop colorectal cancer
Authors: Turri Giulia , Caligola Simone , Ugel Stefano , Conti Cristian , Zenuni Silvia , Barresi Valeria , Ruzzenente Andrea , Lippi Giuseppe , Scarpa Aldo , Bronte Vincenzo , Guglielmi Alfredo , Pedrazzani Corrado 
Published: June 2023

IntroductionEmerging evidence is pointing towards a relevant role of immunity in cancer development. Alterations in leukocytes count and neutrophil-to-lymphocyte ratio (NLR) at diagnosis of colorectal cancer (CRC) seems to predict poor prognosis, but no data is available for the pre-diagnostic values.MethodsRetrospective analysis of patients who underwent surgery for CRC at our center (2005 – 2020). 334 patients with a complete blood count dating at least 24 months prior to diagnosis were included. Changes in pre-diagnosis values of leukocytes (Pre-Leu), lymphocytes (Pre-Lymph), neutrophils (Pre-Neut), and NLR (Pre-NLR) and their correlation with overall- (OS) and cancer-related survival (CRS) were analyzed.ResultsPre-Leu, Pre-Neut and Pre-NLR showed an increasing trend approaching the date of diagnosis, while Pre-Lymph tended to decrease. The parameters were tested for associations with survival after surgery through multivariable analysis. After adjusting for potential confounding factors, Pre-Leu, Pre-Neut, Pre-Lymph and Pre-NLR resulted independent prognostic factors for OS and CRS. On sub-group analysis considering the interval between blood sampling and surgery, higher Pre-Leu, Pre-Neut, and Pre-NLR and lower Pre-Lymph were associated with worse CRS, and the effect was more evident when blood samples were closer to surgery.ConclusionTo our knowledge, this is the first study showing a significant correlation between pre-diagnosis immune profile and prognosis in CRC.
VGLL3 expression is associated with macrophage infiltration and predicts poor prognosis in epithelial ovarian cancer
Authors: Haque Razaul , Lee Jaebon , Chung Joon-Yong , Shin Ha-Yeon , Kim Hyosun , Kim Jae-Hoon , Yun Jae Won , Kang Eun-Suk 
Published: June 2023

Background/objectiveHigh-grade serous ovarian carcinoma (HGSOC) is the most common histologic type of epithelial ovarian cancer (EOC). Due to its poor survival outcomes, it is essential to identify novel biomarkers and therapeutic targets. The hippo pathway is crucial in various cancers, including gynaecological cancers. Herein, we examined the expression of the key genes of the hippo pathway and their relationship with clinicopathological significance, immune cells infiltration and the prognosis of HGSOC.MethodsThe Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data were curated to analyse the mRNA expression as well as the clinicopathological association and correlation with immune cell infiltration in HGSOC. The protein levels of significant genes in the HGSOC tissue were analysed using Tissue Microarray (TMA)-based immunohistochemistry. Finally, DEGs pathway analysis was performed to find the signalling pathways associated with VGLL3.ResultsVGLL3 mRNA expression was significantly correlated with both advanced tumor stage and poor overall survival (OS) (p=0.046 and p=0.003, respectively). The result of IHC analysis also supported the association of VGLL3 protein with poor OS. Further, VGLL3 expression was significantly associated with tumor infiltrating macrophages. VGLL3 expression and macrophages infiltration were both found to be independent prognostic factors (p=0.003 and p=0.024, respectively) for HGSOC. VGLL3 was associated with four known and three novel cancer-related signalling pathways, thus implying that VGLL3 is involved in the deregulation of many genes and pathways.ConclusionOur study revealed that VGLL3 may play a distinct role in clinical outcomes and immune cell infiltration in patients with HGSOC and that it could potentially be a prognostic marker of EOC.
Association of extent of resection on recurrence-free survival and functional outcome in vestibular schwannoma of the elderly
Authors: Wang Sophie Shih-Yüng , Machetanz Kathrin , Ebner Florian , Naros Georgios , Tatagiba Marcos 
Published: June 2023

BackgroundDespite the ongoing debate on the risk–benefit ratio of vestibular schwannoma (VS) treatment options, watchful observation and radiation are usually favored in the elderly (&gt;65 years). If surgery is inevitable, a multimodal approach after deliberate subtotal resection has been described as a valid option. The relationship between the extent of resection (EOR) of surgical and functional outcomes and recurrence-free survival (RFS) remains unclear. This present study aims to evaluate the functional outcome and RFS of the elderly in relation to the EOR.MethodsThis matched cohort study analyzed all consecutive elderly VS patients treated at a tertiary referral center since 2005. A separate cohort (&lt;65 years) served as a matched control group (young). Clinical status was assessed by the Charlson Comorbidity Index (CCI), the Karnofsky Performance (KPS), and the Gardner and Robertson (GR) and House &amp; Brackmann (H&amp;B) scales. RFS was evaluated by Kaplan–Meier analysis using contrast-enhanced magnetic resonance imaging to identify tumor recurrence.ResultsAmong 2,191 patients, 296 (14%) patients were classified as elderly, of whom 133 (41%) were treated surgically. The elderly were characterized by a higher preoperative morbidity and worse gait uncertainty. Postoperative mortality (0.8% and 1%), morbidity (13% and 14%), and the functional outcome (G&amp;R, H&amp;B, and KPS) did not differ between the elderly and the young. There was a significant benefit in regard to the preoperative imbalance. Gross total resection (GTR) was accomplished in 74% of all cases. Lower grades of the EOR (subtotal and decompressive surgery) raised the incidence of recurrence significantly. Mean time to recurrence in the surgELDERLY was 67.33 ± 42.02 months and 63.2 ± 70.98 months in the surgCONTROL.ConclusionsSurgical VS treatment aiming for complete tumor resection is feasible and safe, even in advanced age. A higher EOR is not associated with cranial nerve deterioration in the elderly compared to the young. In contrast, the EOR determines RFS and the incidence of recurrence/progression in both study cohorts. If surgery is indicated in the elderly, GTR can be intended safely, and if only subtotal resection is achieved, further adjuvant therapy, e.g., radiotherapy, should be discussed in the elderly, as the incidence of recurrence is not significantly lower compared to the young.
Pediatric antibiotic stewardship programs in Europe: a pilot survey among delegates of The European Academy of Pediatrics
Authors: Reingold Stephen M. , Grossman Zachi , Hadjipanayis Adamos , Del Torso Stefano , Valiulis Arunas , Dembinski Lukasz , Ashkenazi Shai 
Published: June 2023

BackgroundAntimicrobial resistance (AMR) is one of the leading causes of morbidity and mortality worldwide. Efforts to promote the judicious use of antibiotics and contain AMR are a priority of several medical organizations, including the WHO. One effective way to achieve this goal is the deployment of antibiotic stewardship programs (ASPs). This study aimed to survey the current situation of pediatric ASPs in European countries and establish a baseline for future attempts to harmonize pediatric ASPs and antibiotic use in Europe.MethodsA web-based survey was conducted among national delegates of the European Academy of Paediatrics (EAP). The survey assessed the presence of pediatric ASPs in the representatives’ countries in the inpatient and outpatient settings, the staff included in the programs, and their detailed activities regarding antibiotic use.ResultsOf the 41 EAP delegates surveyed, 27 (66%) responded. Inpatient pediatric ASPs were reported in 74% (20/27) countries, and outpatient programs in 48% (13/27), with considerable variability in their composition and activities. Guidelines for managing pediatric infectious diseases were available in nearly all countries (96%), with those for neonatal infections (96%), pneumonia (93%), urinary tract (89%), peri-operative (82%), and soft tissue (70%) infections being the most common. Pediatric ASPs were reported at the national (63%), institutional (41%), and regional/local (&lt;15%) levels. Pediatricians with infectious disease training (62%) and microbiologists (58%) were the most common members of the program personnel, followed by physician leaders (46%), infectious disease/infection control physicians (39%), pharmacists (31%), and medical director representatives (15%). Activities of the pediatric ASPs included educational programs (85%), monitoring and reporting of antibiotic use (70%) and resistance (67%), periodic audits with feedback (44%), prior approval (44%), and post-prescription review of selected antibiotic agents (33%).ConclusionAlthough pediatric ASPs exist in most European countries, their composition and activities vary considerably across countries. Initiatives to harmonize comprehensive pediatric ASPs across Europe are needed.