bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cognitive consequences of the COVID-19 infection and behavioral variant frontotemporal dementia: Is there a link?
Authors: Costandache G. I. , Oroian B. A. , Salaru A. P. , Ionescu P. F. , Mihai C. 
Published: August 2023

IntroductionFrontotemporal dementia behavioral variant (bvFTD) is the most common subtype of frontotemporal dementia, characterized by early and often severely disabling alterations in personality and social conduct that carry a huge impact on the patient, family, and society.ObjectivesThe aim of the study was to correlate the clinical data collected from our patient with relevant literature and discuss the diagnosis of bvFTD in the context of the COVID-19 pandemic.MethodsCase report and a systematic review of the literature.ResultsThe middle-aged female patient we examined presented an array of psychiatric symptoms, including cognitive, behavioral, and personality changes that emerged in two months after a mild form of SARS-CoV-2 infection. Objectively, a cranial CT scan displayed frontal and anterior temporal lobe atrophy. The rapid and severe decline of the patient’s mental faculties throughout the last year, along with the circumstances in which the pathology developed, raised a question about the etiological factors that contributed to this early-onset dementia.ConclusionsAlthough diagnostic criteria are useful, frontotemporal dementia may be difficult to differentiate from other conditions because there are no disease-specific biomarkers. Correlations between the COVID-19 infection and the fulminant bvFTD symptoms remain unclear and require further investigations.Disclosure of InterestNone Declared
The exploration of interoception construct in COVID-19 survivors
Authors: D’Orsi G. , Palladini M. , Scalabrini A. , Mazza M. G. , Poletti S. , Rovere-Querini P. , Benedetti F. 
Published: August 2023

IntroductionThe new coronavirus disease (COVID-19) has important physical and mental health implications at short and long term. Some inflammatory parameters are implicated in the maintenance of psychiatric symptoms, especially those of anxiety and depression. Additionally, growing literature attributes a role to interoception in several mental health conditions.ObjectivesWe investigated the involvement of the interoception in COVID-19 survivors and its possible associations with psychopathological and inflammatory variables.MethodsOur study included 57 people surviving COVID-19 at one month follow-up after recovery. Individual interoceptive accuracy (IA) measure was obtained through heart-beat perception task. A measure of accuracy in external time perception (TA) was also obtained asking people to mentally produce a duration of 10s. Each participant completed State-Trait Anxiety Inventory - STAI-Y; Zung Self-Rating Depression Scale - ZSDS; Beck Depression Inventory - BDI-II; Impact of Events Scale - IES-R and Multidimensional Assessment of Interoceptive Awareness - MAIA. Peripheral inflammation markers were obtained in a subsample of 40 people by a blood sampling conducted at the time of admission and discharge from hospital. Correlation, regression and GLM analyses were performed with SPSS. Mediation analysis were performed with Hayes’ Process tool.ResultsTA is not associated with IA, symptomatological measures and bodily awareness. Trusting is the only aspect of body awareness associated with IA (p=.021). Noticing (p=.010), Not-distracting (p=.009), Not-worrying (p=.012) and Trusting (p=.001) predict anxiety psychopathology. Poor IA predict anxiety symptomatology (p=.004) and part of this effect is mediated by Trusting [Fig.1]. In the end, platelets count at the time of hospitalization negatively correlates with anxiety symptoms (p=.003).Image:ConclusionsCOVID-19 hospitalization could be considered a psychophysical traumatic experience which involved mental and physical health and the connection and integration between them. It’s necessary to deepen the different facets of body awareness and IA in post-covid stages and to study how interoceptive dimensions change over time. Further research is needed to investigate the specific role of platelets in prominent anxiety psychopathology detected in COVID-19 survivors, wondering about their possible involvement in the dysfunctional interoception process too.Disclosure of InterestNone Declared
THE COMPLIANCE OF PSYCHIATRIC PATIENTS WITH HYPERTENSION TO MEDICATION AND FOLLOW-UP DURING THE COVID-19 PANDEMIC
Authors: Anagnostaki M. E. , Anagnostaki I. , Papaspiropoulou G. 
Published: August 2023

IntroductionThe current SARS Covid-19 pandemic has negatively affected primary care and health system services provided to chronically ill patients, such as patients with Diabetes Mellitus, Dyslipidemia and Hypertension.ObjectivesThe recording of the number of unfulfilled scheduled visits of Psychiatric patients who are monitored in the Pathological Outpatient Clinic of Arterial Hypertension at the Psychiatric Hospital of Attica due to non-attendance, before the pandemic (9/2018 -2/2020) and during its evolution (3/2020-2 /2022).MethodsThe study was done retrospectively and included 1515 patients with a Psychiatric history and concomitant Hypertension who were examined at Outpatient Clinics during the aforementioned time intervals. The rates of missed scheduled visits, as well as discontinuation of treatment without a doctor’s indication were compared and the statistical method used was χ2 with a significance level of p<0.05.ResultsThe percentage of scheduled appointments that did not take place due to patient no-shows during the pre-pandemic period was 22% (550/2500). During the pandemic the non-attendance rate increased to 36% (1132/3145). The increase in the rate of missed appointments was statistically significant with p<0.001. Correspondingly, the difference in recorded discontinuation of treatment was statistically significant, 26% (523/2011) versus 33% 743/2252).ConclusionsΣτην παρούσα μελέτη διαπιστώνεται στατιστικά σημαντική αύξηση της μη προσέλευσης Ψυχιατρικών ασθενών στα Παθολογικά Εξωτερικά Ιατρεία τη περίοδο της πανδημίας. Επίσης το πρόβλημα της μη συμμόρφωσης στη συνιστώμενη αγωγή διογκώθηκε καθώς καταγράφηκε μεγαλύτερο ποσοστό μη συνιστώμενης διακοπής αγωγής για την Αρτηριακή Υπέρταση .Disclosure of InterestNone Declared
COVID-19-associated schizophrenia-like psychosis during the COVID-19 pandemic
Authors: Bravve L. , Zakharova N. 
Published: August 2023

IntroductionThe viral theory of the development of psychoses was formulated in the 19th century, but the role of viral agents in the pathogenesis of psychoses remains a matter of debate. In the context of the 2020 pandemic, the results of several papers on the characteristics of psychotic disorders in COVID-19 have been published. Coronaviruses are neuroinvasive, capable of affecting mental and body functions.ObjectivesThe aim of the study was to identify patients with acute psychosis without a history of mental disorders in order to test the hypothesis about the possibility of manifestation of schizophreniform psychosis due to a viral attack.MethodsWithin a year and a half, 50 patients with mental disorders associated with COVID-19 were identified. The reason for hospitalization in a psychiatric hospital is the development of acute schizophreniform psychosis against the background of a new coronavirus infection. The diagnosis was verified according to traditional clinical criteria and modern psychometric tools. Inclusion criteria: no previous visits to a psychiatrist; verified acute polymorphic psychotic disorder and coronavirus infection COVID-19 (ICD-10); manifestation of psychosis against the background of infection with COVID-19; age 18-60 years; consent to participate in the study. Exclusion criteria: signs of organic brain damage; indications of substance abuse; delirium of any etiology; somatic pathology in the stage of decompensation.Results27 women (54%) and 23 men (46%), aged 20 to 57 years (average age 34.5±7.6), of which 18 people (36%) worked, 2 (4%) studied , 29 (58%) people are unemployed. 27 people (54%) are single, 16 (32%) are married, 7 (14%) are divorced; 18 people (36%) were raising children, which indirectly indicated a relatively favorable premorbid functioning. At the time of the examination, the condition was determined by polymorphic psychotic symptoms with a predominance of dissociative-delusional, paraphrenic and oneiric phenomena with plots containing plots of infection and the spread of coronavirus. At the same time, the sum of PANSS is from 53 to 130 (85) points, including PANSS P - from 15 to 37 (27), PANSS N - from 7 to 44 (18), PANSS G - from 23 to 57 (39.9 ); P1 - 5.7; P3 - 5.1. When comparing the obtained data with the world experience, we found some differences. Delusional symptoms were diagnosed twice as rarely, cases with tactile hallucinations were not detected, but catatonic symptoms were observed twice as often, and manic arousal was twice as rare. In general, the studied data are comparable with the results published in the world practice.ConclusionsThe unique experience of the coronavirus pandemic will allow us to assess the influence of environmental factors, namely the role of infections, in the manifestation or predisposition to schizophrenia spectrum disorders. It is planned to evaluate the dynamics of the course of the disorder after the relief of the acute period.Disclosure of InterestNone Declared
The use of antidementia therapy in non-dementia cognitive disorders associated with COVID-19
Authors: Liubov P. , Iashina I. 
Published: August 2023

IntroductionThe new coronavirus infection causes severe damage to the human body. One of the most serious complication is cognitive impairment.According to a meta-analysis by Maxime Taquet et al. (2021), which assessed neurological and psychiatric outcomes among 236,379 patients diagnosed with COVID-19, 1.7% of participants over 65 years of age were diagnosed with dementia.In a US online survey of 1,500 people (Sarah Ballou et al., 2020), about half reported difficulty concentrating on any task after experiencing COVID-19.It was also found that there is a decrease in the speed of reactions and problem-solving (Jeffrey D. Pyne et al., 2021).There are a number of studies that present the evidence-based efficacy of acetylcholinesterase (AChE) inhibitors in dementia prevention.However, in accordance with clinical guidelines for cognitive disorders in the elderly, anti-dementia drugs are not used at the stage of mild to moderate cognitive impairment (Ministry of Health of the Russian Federation, 2020).ObjectivesThe use of AChE inhibitors in cognitive impairments that do not reach the degree of dementia.MethodsResearch data from open sources.ResultsThe development of early cholinergic deficiency correlates with the development of cognitive impairment, while acetylcholine has a pronounced neuroplastic effect and increases the number of neurons (Gabriela Dumitrita Stanciu et al., 2019).In a double-blind, placebo-controlled study, a positive effect of rivastigmine was found in patients with mild to moderate cognitive impairment. The study’s results show that rivastigmine treatment (3, 6, 9 mg/day) for six months increases brain activity of the hippocampus in the control group by 32,5%. Rivastigmine prevented the clinical progression of symptoms of cognitive impairment and caused activation of some parts of the cerebral cortex (Nagaendran Kandiah et al., 2017).In a study by Wolfson C. et al. (2002), it was found that rivastigmine can slow down the development of cognitive impairment for at least six months in patients with mild to moderate massive cognitive dysfunction. Subjects treated with 1 to 21 mg per day for 7 to 12 weeks got more favorable ADAS-cog scores for the six months after treatment. While those who took the drug in doses of 6 to 12 mg showed a more pronounced positive effect compared to the placebo group.The Luca Rozzini in 2006 conducted a study based on 59 subjects with mild cognitive impairment. 15 subjects received both neuropsychological examination and acetylcholinesterase inhibitors. As a result, the remaining subjects were behind in terms of abstract thinking and behavioral symptoms, in comparison with a combined treatment group.ConclusionsIt is advisable to conduct further studies on the effectiveness of AChE inhibitors to prevent the progression of mild to moderate cognitive impairment and their transition to dementia.Disclosure of InterestNone Declared
Quality of life and fear of death among patients living with HIV during the COVID-19 pandemic second wave
Authors: Titova V. V. , Rozhdestvenskiy V. I. , Gorkovaya I. A. , Ivanov D. O. , Aleksandrovich Y. S. 
Published: August 2023

IntroductionThe new coronavirus pandemic has brought the issue of life quality to the forefront. Among HIV-infected patients, life quality may be associated with fear of death.ObjectivesThe study aimed to investigate the life quality and death fear among HIV-infected patients during the pandemic second wave in Russia.MethodsThe data were collected from February to July 2021 using a Google form that we developed. Fifty-nine patients living with HIV participated in the study. We used the WHOQOL-BREF to examine the quality of life and the Fear of Personal Death Scale to explore fear of death. Both questionnaires were adapted for use in Russia.ResultsWe found the following mean values for the domains: “physical and psychological well-being” — M = 21.39±3.61; “self-perception” — M = 17.51±2.28; “microsocial support” — M = 9.15±2.94; “social well-being” — M = 24.81±5.33. We found that physical and psychological well-being were associated with the transcendental consequences of death (rxy = 0.274, p < 0.05), self-perception with body consequences (rxy = -0.304, p < 0.05) and fear of forgetting (rxy = -0.287, p < 0.05), and social well-being with body consequences (rxy = -0.310, p < 0.05).ConclusionsLife quality is related to intrapersonal, interpersonal, and supra-personal dimensions of death fear during the second wave of the pandemic among patients living with HIV. Such fact may indicate possible psychotherapeutic targets when working with this group of patients.Disclosure of InterestNone Declared
Individual behaviour self-regulation and emotional reactions among patients living with HIV during the second wave of the new coronavirus pandemic in Russia
Authors: Rozhdestvenskiy V. I. , Titova V. V. , Gorkovaya I. A. , Ivanov D. O. , Aleksandrovich Y. S. 
Published: August 2023

IntroductionDuring the COVID-19 pandemic, the need to adapt to rapidly changing external conditions has increased dramatically. Predictors of successful adaptation can be the degree of development of individual self-regulation and its profile. The emotional state depends on successful adaptation.ObjectivesThe study aimed to examine the individual self-regulation of behaviour and emotional reactions among patients living with HIV in Russia.MethodsThe data were collected from February to July 2021 using a Google form developed by us. Fifty-nine HIV-positive patients participated in the study. To diagnose the development of individual self-regulation and its profile, we used the Self-Regulation Style Questionnaire, to study depression, anxiety, and stress — DASS-21 adapted for use in Russia.ResultsWe found that 10 % of respondents had a low overall level of self-regulation, 53 % had an average level, and 37 % had a high level. The average individual profile was as follows: predominance of planning (M = 6.24±1.90) over modelling (M = 5.69±1.90), programming (M = 5.93±1.66), and evaluating results (M = 5.78±1.60), which were approximately at the same level. Flexibility (M = 6.58±1.90) and autonomy (M = 5.56±2.08) scores were in the average normal range. Only two correlations were found: modelling was negatively associated with depression (rxy = -0.336, p < 0.01) and anxiety (rxy = -0.275, p < 0.05).ConclusionsAwareness and adequacy of perceptions of changes in external and internal significant conditions contribute to a favourable emotional status among people living with HIV.Disclosure of InterestNone Declared
Atopic Dermatitis and Major Depressive Disorder: is there causality?
Authors: Reis C. S. , Vieira A. , Martins P. S. 
Published: August 2023

IntroductionThe association between Atopic Dermatitis (AD) and Major Depressive Disorder (MDD) has long been reported by some population-based observational studies. However, observational studies are susceptible to potential confounders and inverse causation, rendering it difficult to conclude about the causality of such association. Mendelian randomization (MR) analysis is a novel epidemiological method to assess the causation between an exposure and an outcome, with less susceptibility to potential confounders and reverse causation by using genetic variants as instrumental variables.ObjectivesTo report a clinical case of depression in association with atopic dermatitis and to review what contributions MR studies have been bringing to the matter of causality between AD and MDD.MethodsCase report and literature review based on PubMed using the terms “atopic dermatitis”, “eczema”, “depression", “depressive”, “mood” and “Mendelian randomization”, which were searched in the title and abstract fields.ResultsCase-report: A 26-year-old man was admitted for inpatient treatment with a clinical picture of sadness, irritability, social isolation and insomnia, with 4 months of evolution, aggravated by suicidal ideation in the preceding days. On examination of the mental status, the patient had a frankly depressed mood, with congruent affects. He was contemplating suicide methods, pointing to sodium nitrite intoxication as an option. The patient related these symptoms to the worsening of his atopic dermatitis. In fact, he had a history of other depressive episodes contemporaries with periods of dermatological worsening.Literature review: The PubMed research identified 7 articles, 4 of which assessed the causal effect of AD on MDD. Three studies did support a causal effect of AD genetic risk on MDD. One study supported a small causal effect of AD on MDD, with the significance disappearing when a stricter threshold for selection of single-nucleotide polymorphisms was applied.ConclusionsThe MR studies included in this poster favour the absence of a causal effect of AD on MDD, suggesting that the comorbidity observed clinically is unlikely to be causal. We must be aware that these studies are few and are not free of limitations (e.g. subgroup analysis for age and severity was not carried out, AD and MDD diagnosis were self-reported in some cases). Further research may help clarify the existence of causality and/or uncover the factors responsible for the observed association of AD with MDD in observational studies.Disclosure of InterestNone Declared
The involvement of Croatian psychiatrists in helping the displaced persons from Ukraine
Authors: Rojnic Kuzman M. 
Published: August 2023

AbstractAfter two years of pandemic with COVID-19 Europe is facing a war, which has already caused numerous death and injuries, mass displacement, and aggravated the economic and energy crisis and has left most countries completely unprepared and created a humanitarian crisis. The COVID-19 pandemics crisis pointed out the unpreparedness of the health (including mental health) sectors for the emergency situations. However, we also learnt some of the practices that proved effective – including the fast creation of collaborative networks on a larger scale that also allowed fast spread of good practices and practical organisation of help. The European Psychiatric Association as well as individual national psychiatric association have started an informal network of solidarity for Ukraine on February 28th, 2022 to respond to the needs of people in Ukraine as verbalized by the Ukrainian mental health professionals, but also to the need of surrounding countries where people from Ukraine fled to. Through this network several actions, including financial support, medical donations and education. The Croatian Psychiatric Association took the lead in the organisation of education for first line helpers and volunteers from Ukraine and countries surrounding Ukraine where displaced persons fled to, in collaboration with many partners.Disclosure of InterestNone Declared
The therapeutic potential of psilocybin in depression resistant to psychotropic drugs
Authors: Ramírez González J. , Fernández Márquez I. , Ferreiro González S. , Ruíz E. M. 
Published: August 2023

IntroductionThe use of hallucinogens has accompanied the human being throughout history. In the 1970s, studies focused on the therapeutic potential of hallucinogens were blocked due to their misuse in the young population. At present, psilocybin is re-emerging as the center of attention due to its possible therapeutic potential in different psychiatric pathologies such as depression, anxiety or substance use.ObjectivesThe main objective of this work has been to review recent studies on the therapeutic potential of psilocybin in drug-resistant depressive disorder.MethodsFor the search for articles, the search strategy “psilocybin AND depression” was established in PUBMED. Regarding the inclusion criteria, it was established that they were recent articles, in Spanish or English and that the full text was freely accessible. On the other hand, those articles whose studies did not focus on humans and resistant depressive disorder were excluded. A total of 19 articles were obtained to review.ResultsFocusing on Drug-Resistant Depressive Disorder, multiple studies have agreed that the administration of one or two microdoses (10-25mg) of psilocybin accompanied by psychotherapy improves the clinical picture for at least 6 months. These results make us feel optimistic in the search for new treatments in the field of mental health.ConclusionsPsilocybin microdoses associated with psychotherapy improves depressive symptoms in a patient resistant to common antidepressants.The psilocybin response in terms of improvement of the depressive symptoms persists after 6 months of evolution.One or, in some two cases, two microdoses of psilocybin (10-25mg) are enough to obtain statistically significant results in the improvement of the depressive symptoms.Disclosure of InterestNone Declared
High number of refugees in Germany - how is the mental health care dealing with this major challenge?
Authors: Schouler-Ocak M. 
Published: August 2023

AbstractEurope is again confronted with a new dramatic emergency, a war which has already caused civil victims, mass displacement and even fear about a nuclear war and energy crisis. Again, Europe is facing new waves of war refugees, forcibly displaced people. There is increasing evidence that a large proportion of refugees or forcibly displaced persons suffer from the consequences of traumatic events and exhibit psychological problems or develop mental disorders, including post-traumatic stress disorder, depressive and anxiety disorders, and relapses in psychotic episodes. European countries are trying to face with an extraordinary surge of solidarity and generosity, but at the same time with the awareness that the needs are much beyond reaction capacity of individual people and states. The direct and indirect consequences of this humanitarian catastrophe cannot be estimated at present. Mental healthcare services are suddenly faced with major challenges and need to develop or expand strategies to address them. In this presentation, strategies from Germany will be presented and discussed.Disclosure of InterestNone Declared