bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic effect of growth factor receptor-bound protein 2/epidermal growth factor receptor dual-targeting peptide inhibitor and salinomycin on osteosarcoma
Authors: Yu Zuochong , Xu Yanlong , Du Longhai , Zhang Fan , Shao Minghao , Xie Lin , Cai Guoping , Lyu Feizhou 
Published: March 2023

Context:
The growth factor receptor-bound protein 2 (Grb2)-Sos1 interaction, mediated by modular domains, plays an essential role in the oncogenic MAPK signaling pathway in osteosarcoma (OS). Recently, a dual-targeting peptide that targets the epidermal growth factor receptor and Grb2-Src homology 3 domain in OS cells was designed and synthesized.

Aims:
We investigated the synergistic effects of the peptide and salinomycin (Sal), a chemotherapeutic drug with effective anti-OS properties in clinical therapy.

Subjects and Methods:
Flow cytometry was used to measure the targeting efficacy of the peptide. Migration and CCK-8 assays were used to explore whether Sal and the peptide could synergistically inhibit OS cell behavior. Western blotting was used to detect apoptosis.

Statistical Analysis Used:
Data were analyzed using the GraphPad Prism 5.01. Statistical analysis was performed using the Student's t-test for the direct comparisons and one-way analysis of variance for the comparisons among the multiple groups. Statistical significance was set at P < 0.05.

Results:
The peptide was shown to target OS cells. When applied together, Sal and the peptide synergistically inhibited OS cell migration, invasion, and proliferation through the inhibition of Grb2-Sos1. This synergistic treatment also promoted the apoptosis of OS cells and inhibited tumor volume in vivo.

Conclusions:
These data provide valuable insights into the molecular mechanisms of OS and may be beneficial in clinical therapy.
Golgi phosphoprotein 3 promotes ovarian cancer progression and is associated with cisplatin resistance
Authors: Liu Teng , Jin Zhen-Wei , Li Ying , Zhang Ge , Yang Xiao-Ying , Xu Xiao-Meng , Ma Ying-Chun 
Published: March 2023

Background:
Golgi phosphoprotein-3 (GOLPH 3) is involved in the development of several human cancers. However, the clinical significance and biological role of GOLPH 3 in ovarian cancer (OC) remains unknown.

Methods:
The expression of GOLPH 3 in OC cell lines was quantified using real-time quantitative polymerase chain reaction (RT-qPCR) and western blot assays. The role of GOLPH 3 in tumorigenicity, migration, and invasion of OC cell lines by small interference RNA, scratch wound-healing assays, and transwell assays was detected. In addition, western blotting was used to determine whether GOLPH 3 is associated with the PI3K/AKT/mTOR signaling pathway. Furthermore, RT-qPCR verified whether GOLPH 3 is associated with drug resistance.

Results:
GOLPH 3-positive expression rate was higher in OC. Downregulation of GOLPH 3 markedly inhibited the migration and invasion and may be related to the PI3K/AKT/mTOR signal pathway. Moreover, the result of the experiment proved that GOLPH 3 enhances the sensitivity of OC to cisplatin by regulating ATP7A/B. GOLPH 3 promoted the invasion and migration of OC, and the mechanism may be related to the PI3K/Akt/mTOR pathway. In addition, inhibition of GOLPH 3 increased the sensitivity of OC cells to cisplatin, which may be associated with ATP7A/B.

Conclusion:
This study found that GOLPH3 may promote the migration and invasion of OC cells through PI3K/Akt/mTOR pathway. At the same time, low expression of GOLPH3 increased the sensitivity of OC cells to cisplatin.
Elevated β-catenin and C-myc promote malignancy, relapse, and indicate poor prognosis in patients with relapsed glioma
Authors: Yu Xuejuan , Xiao Fengxia , Wei Yuzhen , Miao Lifeng , Zhang Wei , Zhang Xin , Wang Dexiang 
Published: March 2023

Context:
Extensive studies have shown that β-catenin and C-myc have been linked to a number of human cancers. However, the role of β-catenin and C-myc in relapse glioma remains unclear.

Aims:
The aims of this study were to investigate the role of β-catenin and C-myc in relapsed glioma patients and to explore the possible impact of malignancy, relapse, and prognosis.

Materials and Methods:
We collected surgical samples of 100 patients with primary and relapsed glioma treated at our institution. Immunohistochemistry (IHC) staining was used to evaluate the expressions of β-catenin and C-myc. The impact of the differences on disease-free interval (DFI), initial overall survival (iOS), and overall survival from the time of glioma relapse (rOS) of the patients was analyzed. Kaplan–Meier survival functions were used to plot survival time, and a log-rank test was used for analyzing statistical significance. Cox multivariate regression analysis was used to determine independent prognostic parameters.

Results:
Compared to primary tumors, relapsed gliomas had higher expressions of β-catenin and C-myc (P < 0.05). Furthermore, the expressions of β-catenin and C-myc were significantly correlated with glioma grade (P < 0.05). These changes in expression at the time of relapse were independent of radiotherapy use. In multivariate Cox analysis, we found that β-catenin and C-myc were independent prognostic factors for rOS (P < 0.05).

Conclusions:
Elevated β-catenin and C-myc promote malignancy, relapse, and indicate poor prognosis in patients with relapsed glioma. The elevated levels of β-catenin and c-myc in relapsed glioma were not affected by radiation therapy. The results of this study may provide a new therapeutic target for patients with relapsed glioma.
Knowledge and Perception of the Practice of Nuclear Medicine Among Physicians in Usmanu Danfodiyo University Teaching Hospital, Sokoto
Authors: Isah Ahmed Rufai , Abdulqadir Ibrahim , Adamu Habibullah , Aliyu Usman Malami , Abubakar Sofiyullah , Yunusa Garba Haruna , Jawa Zabah Muhammad 
Published: March 2023

Background:
The management of Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, since the year 2011 set the machinery to establish a Department of Nuclear Medicine (NM). The objective of this study is to evaluate the physicians' knowledge and perception of the practice of NM, with a view of improving these when NM services commence at UDUTH, Sokoto.

Methods:
An anonymized electronic questionnaire was used to conduct this cross-sectional study. The questionnaire had three sections, comprising responders' demography, basic knowledge of NM, and physicians' perception of the practice of NM. The data were collated in an Excel spreadsheet (version 16.53, 2019), and the IBM SPSS package (version 27, 2020) was used to conduct the descriptive statistical tests.

Results:
Seventy-six doctors participated in the study. Of this figure, females were 19 (24.7%), whereas 57 (75.3%) were males. In terms of designation, there were 2 (2.6%) house officers, 22 (28.6%) registrars, 25 (32.5%) senior registrars, and 27 (35.1%) consultants. Fifty-one (67.1%) respondents clearly understand what NM is, while 18 (23.7%) wrongly identified NM as the field of medicine that uses machines that produces radiation to diagnose and treat certain illnesses, 2 (2.6%) respondents did not respond, while 5 (6.6%) were not sure. Only three (2.6%) physicians were able to correctly identify the rays/particles that are used in NM (beta rays, gamma rays, alpha rays, and positron), the majority of 25 (32.9%) identified gamma rays as the only rays used in NM.

Conclusion:
The study shows low awareness on what NM is about and the perception on the role of NM in clinical practice is also poor. This has demonstrated the need to enlighten them through lecture and seminar presentations. There is a need for the NM centers in the country to collaborate with the referring clinicians with a view to create awareness on the role of NM services and where these services can be accessed.
Concept of body image and its mental health implications
Authors: Choudhary Prashant , Upadhyay Saumya , Kar Sujita Kumar 
Published: March 2023

Abstract
Individual's impressions about their bodies may differ from cultural standards and expectations and can lead to either contentment or discontent. Dissatisfaction with one's body has been observed in populations as young as 5–7 years old and the elderly. Variations are also noticed across ages, gender, and social strata, also influenced by peer feedback and societal assessment. A broad spectrum of mental health issues as well many physical conditions associated with obvious or acquired disfigurements are impacted by body image. Many instruments, including self-report questionnaires and projective tests, have been developed over time to measure various aspects of body image across different stages of life. Treatment options include cognitive behavioral therapy, embodiment intervention techniques, mirror therapy, and assistance from virtual reality.
Aortic Stenosis Detection Using Spectral Statistical Features of Heart Sound Signals
Authors: Kumar S. V. Mahesh , Dhinakar P. , Nishanth R. 
Published: March 2023

INTRODUCTION: Aortic stenosis (AS) is a severe complicated heart valve disease. This valve abnormality is a slow-progressive condition and mostly asymptomatic. Hence, there is a need for a rapid non-invasive AS diagnosis method with minimal feature extraction.
OBJECTIVE: In this paper, we proposed a rapid spectral analysis-based statistical feature extraction method to identify the AS stages with the minimum number of features.
METHODS: In this study, the heart sound signals were collected from the medical database and transformed into the frequency domain for further spectral feature analysis. We used the windowing technique to condition the heart signals before spectral analysis. The spectral statistical features were extracted from the computed frequency spectrum. The range of statistical features was compared for normal, early, and delayed AS groups.
RESULTS: In experiments, the normal, early, and delayed AS heart sound signals were used. The experimental results show the statistical difference between the normal and AS heart sound signal spectrums. The normal/unhealthy condition of a heart was identified using the statistical features of the frequency spectrum.
CONCLUSION: The experimental results confirmed that the statistical features derived from the heart sound signal spectrums were varied according to the AS condition. Hence, the spectral statistical features can be considered as a rapid predictor of AS.
Oxygen Consumption with High-Flow Nasal Oxygen versus Mechanical Ventilation— An International Multicenter Observational Study in COVID–19 Patients (PROXY–COVID)
Authors: Botta Michela , Caritg Oriol , van Meenen David M.P. , Pacheco Andrés , Tsonas Anissa M. , Mooij Willemijn E. , Burgener Alessia , Manrique Hehl Tosca , Shrestha Gentle S. , Horn Janneke , Tuinman Pieter R. , Paulus Frederique , Roca Oriol , Schultz Marcus J. 
Published: March 2023

ABSTRACT.
The COVID–19 pandemic led to local oxygen shortages worldwide. To gain a better understanding of oxygen consumption with different respiratory supportive therapies, we conducted an international multicenter observational study to determine the precise amount of oxygen consumption with high-flow nasal oxygen (HFNO) and with mechanical ventilation. A retrospective observational study was conducted in three intensive care units (ICUs) in the Netherlands and Spain. Patients were classified as HFNO patients or ventilated patients, according to the mode of oxygen supplementation with which a patient started. The primary endpoint was actual oxygen consumption; secondary endpoints were hourly and total oxygen consumption during the first two full calendar days. Of 275 patients, 147 started with HFNO and 128 with mechanical ventilation. Actual oxygen use was 4.9-fold higher in patients who started with HFNO than in patients who started with ventilation (median 14.2 [8.4–18.4] versus 2.9 [1.8–4.1] L/minute; mean difference = 11.3 [95% CI 11.0–11.6] L/minute; P < 0.01). Hourly and total oxygen consumption were 4.8-fold (P < 0.01) and 4.8-fold (P < 0.01) higher. Actual oxygen consumption, hourly oxygen consumption, and total oxygen consumption are substantially higher in patients that start with HFNO compared with patients that start with mechanical ventilation. This information may help hospitals and ICUs predicting oxygen needs during high-demand periods and could guide decisions regarding the source of distribution of medical oxygen.
Nursing Actions after Hip Total Joint Replacement Surgery
Authors: Petravičienė Zita , Bartašiūnienė Vida 
Published: March 2023

The joint replacement surgery is one of the greatest achievements of medicine these days. They are one of the most effective surgical interventions, performed recently, both in medical and economic terms [1].
Every year in Lithuania as well as worldwide, the number of joint replacement surgeries is constantly increasing. This is influenced by the ageing population as well as the increasing number of people with chronic degenerative joint diseases [2].
Despite the fact that hip, knee total joint replacement surgeries have become routine orthopedic surgeries, however, special care and nursing by medical employees are required during the postoperative period.
The purpose of the research. To analyze nursing actions after the hip total joint replacement surgery. A quantitative survey has been performed by the questionnaire method; its participants were nurses, working in health care institutions of Utena City.
The research revealed that the nurses shall assess the patient's general condition, his/her vital indicators, the wound, the drains and solve theproblems that have occurred.
Ethiopian University Students’, Lecturers’ and Administrators’ Perceptions of Interculturally Competent Persons
Authors: Ayana Desta , Sercu Lies 
Published: March 2023

Purpose: This study’s aim was to investigate Ethiopian university students’, lecturers’, and administrators’ perceptions of the dispositions (savoir-être) of interculturally competent persons.
Methodology: Building on seminal models of intercultural competence, a survey instrument was created to inquire into the three stakeholder groups’ perceptions. The survey was completed by 638 participants.
Findings: The paper highlights similarities and differences between students, lecturers, and administrators. The findings also show that African and western characteristics associated with interculturally competent persons reflect the respondents’ personal and professional roles.
Unique Contribution to Theory, Practice and Policy: This study is the first to study Ethiopian students’, lecturers’ and administrators’ perceptions of interculturally competent persons. The study’s findings provide a baseline on which curricula and policies can build in order to promote intercultural competence in Ethiopian universities.
O jogo da velha como alternativa de melhoria no processo de ensino-aprendizagem da Matemática na Educação de Jovens, Adultos e Idosos
Authors: Santos Maxuel Leandro , Cruz Maria Aparecida 
Published: March 2023

RESUMO: Esta pesquisa teve como objetivo analisar se a construção do conhecimento sobre a teoria dos conjuntos com o uso do Jogo da Velha na EJA contribuiu para a melhoria no processo de ensino-aprendizagem, na participação e na interação entre os estudantes do 1º período do Ensino Médio da Educação de Jovens, Adultos e Idosos (EJAI) da rede estadual de ensino do estado de Alagoas. Para atingir esse objetivo foi realizado um estudo bibliográfico que contemplou a caracterização dos os estudantes da EJAI, aspectos epistemológicos da inserção de jogos em sala de aula e as particularidades do Jogo da Velha. A realização do trabalho caracterizou-se como pesquisa-ação, com abordagem qualiquantitativa. A partir dessa análise e da Metodologia da Pesquisa utilizada com questionário de identificação, lista de exercícios e jogo, foi confeccionado um recurso didático denominado Jogo da Velha com Conjuntos que consiste em uma utilização do tradicional Jogo da Velha com algumas alterações, onde nesse novo formato foram abordados os conteúdos da Teoria dos Conjuntos, e após a análise dos dados obtidos como resultado da pesquisa foi possível concluir que o Jogo da Velha com Conjuntos logrou êxito nos objetivos propostos, evidenciando a melhoria no aprendizado com a inserção de jogos.
Palavras-chave: Jogo da Velha, Matemática, Conjuntos.

ABSTRACT: This research aimed to analyze whether the construction of knowledge about the theory of sets with the use of Jogo da Ticla in EJAI contributed to the improvement in the teaching-learning process, in the participation and in the interaction between students of the 1st period of High School Youth, Adult and Elderly Education (EJAI) of the state education network in the state of Alagoas. To achieve this objective, a bibliographical study was carried out that included the characterization of the EJAI students, epistemological aspects of the insertion of games in the classroom and the particularities of the Tic-tac-toe game. The accomplishment of the work was characterized as action-research, with a quali-quantitative approach. Based on this analysis and the Research Methodology used with an identification questionnaire, list of exercises and game, a didactic resource called Tic-Tac-Tac-Toe with Sets was made, which consists of using the traditional T-Tic-tac-Toe Game with some changes, where in this new format The contents of the Theory of Sets were approached, and after analyzing the data obtained as a result of the research, it was possible to conclude that the Tic-Tac-Toe Game with Sets was successful in the proposed objectives, showing the improvement in learning with the insertion of games.
Keywords: Tic-tac-toe, Mathematics, Sets.
A escola do campo
Authors: Farias Susanne Messias de 
Published: March 2023

A escola do campo, por vezes, é tão pequena na estrutura, maior na beleza externa e na força do povo nela habitar, que planta, cuidar e cultiva, dá para vê no olhar de cada ser nela habitar que de lutar em lutar, de grão em grão do litoral ao sertão que alimentar o povão.

A educação do campo é construída num espaço de lutas oriunda de um dívida histórica social, que nessa prosa deve-se considerar e valorizar o homem do campo, com suas raízes na base camponês, que debaixo do sol e da chuva incessante, se faz feliz por alimentar sua gente, dai já faz nova plantação com esse mesmo chão.

A escola do campo é junção de multisseriada, com tanta meninada! E os professorares que vem de legá-las de distância semeando sonhos e cultivo direitos. Na educação do campo vive dias de lutas, para chegar nos dias de glórias, porque sem batalha não há vitória, sendo assim, a escola tem um papel fundamental nas mudanças que precisam ser efetivadas na realidade do campo.

Com tanta coisa boa que tem no campo, uma das melhores é a possibilidades de dinamiza as condições sociais existentes, enquanto projeto de mundo, de homem/mulher e de sociedade, viva a resistência de todos aqueles fazem deste cenário um lugar de educação.
Architecture After Deleuze and Guattari
Authors: Smith Chris L. 
Published: March 2023

This study illuminates the complex interplay between Deleuze and Guattari’s philosophy and architecture. Presenting their wide-ranging impact on late 20th- and 21st-century architecture, each chapter focuses on a core Deleuzian/Guattarian philosophical concept and one key work of architecture which evokes, contorts, or extends it.
Challenging the idea that a concept or theory defines and then produces the physical work and not vice versa, Chris L. Smith positions the relationship between Deleuze and Guattari’s philosophy and the field of architecture as one that is mutually substantiating and constitutive. In this framework, modes of architectural production and experimentation become inextricable from the conceptual territories defined by these two key thinkers, producing a rigorous discussion of theoretical, practical, and experimental engagements with their ideas.
Aluminum phosphide poisoning
Authors: KARAKUŞ Ali 
Published: March 2023

Letter to Editor

Aluminum phosphide poisoning

Dear Editor,

Aluminum phosphide, is a fumigant with high insecticide power in all life stages of insects, which is harmful in stored products.
It is in the form of tablets or granules and is highlylethal and has no antidote.
It inhibits the enyzme of cytochrome oxidase. Complications may develop as a result of inhaling phosphine gas or oral intake. Respiratory, circulatory, gastrointestinal tract andnervous system, kidney and liver may be affected. Shock, ARDS, aspration pnomony, anemia, metabolic acidosis, electrolytic disorder, coma, hipoxy, hemorrhage, pericardide are poorprognosis criterion. Leukopenia indicates severe toxicity. The lethal dose is 0.15-0.5 g and death is inevitableeven when buying 3-5 tablets
Arrhythmia is responsible for death in the first 24 hours.The mortality rate varies between 37-100%.Treatment consists entirely of supportive treatment. (liquid, dopamine, oxygen, mechanical ventilation, gastric washing, activated charcoal,bicarbonate, hemodialysis)We aimed to present the case that developedsystemic complications in follow-up but wedischarged with healing as a result of appropriatefollow-up and treatment.
CASE
A 16-year old female patient was rushed to theemergency room two hours ago for drinking morethan she
knew the amount of the drug containing aluminum phosphide for suicidal purposes.
When the patient arrived, his general condition wasmoderate, conscious, pale sweaty appearance and Tachypnea, BREATHING:26/min, TA:60/40mmhg,Pulse:135/min,,fever:37 degree systemic examination showed no abnormalities.
Initial blood values, ECG and chest x-ray were normal.

The patient was followed up in the emergency department. 1000ml serum physiological started
In order to reduce the formation of phosphine gas(with alkalısm), oral bicarbonate was started.
Ta:100/70mmHg in the 2nd hour of follow-up andchest pain developed.
The first TROPONIN I value was:0.02(0-0.06 ng/ml). In echocardiography, ejection fraction wasdetermined 57%. In the blood gas, PH was 7.32 and there was metabolic acidosis. Her acidosis level improved in the 6th hour of the follow up. The control TROPONİN value was 0.21. Asetilsalisilik acid started at 100 mg. At the 12th hour white blood cell (4-11 k/ml) decreased from 12000 to 4000.However no abnormality was detected in other hemogram values.

At the 20th hour ,her chest pain gone and her troponin values increased up to 1.45.No ECG change detected.Her acidose improved and lokopenia not seen.The patient’s control , liver and kidney function tests and ECHO were normal.No abnormality was detected in the follow ups , polyclinic controls and laboratory values on the third day of the hospitalization. The patient was discharged from the hospital with suggestions.

Aluminum phosphide is an extremely mortal toxic substance.During the follow ups unwanted complications can develop. Merely satisfactory results can be achieved with valid , timely and appropriate supportive treatments
Fast approximate Barnes interpolation: illustrated by Python-Numba implementation fast-barnes-py v1.0
Authors: Zürcher Bruno K. 
Published: March 2023

Abstract. Barnes interpolation is a method that is widely used in geospatial sciences like meteorology to remodel data values recorded at irregularly distributed points into a representative analytical field. When implemented naively, the effort to calculate Barnes interpolation depends on the product of the number of sample points N and the number of grid points W×H, resulting in a computational complexity of O(N⋅W⋅H). In the era of highly resolved grids and overwhelming numbers of sample points, which originate, e.g., from the Internet of Things or crowd-sourced data, this computation can be quite demanding, even on high-performance machines. This paper presents new approaches of how very good approximations of Barnes interpolation can be implemented using fast algorithms that have a computational complexity of O(N+W⋅H). Two use cases in particular are considered, namely (1) where the used grid is embedded in the Euclidean plane and (2) where the grid is located on the unit sphere.