bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forging New Voice Mechanisms From a Crisis—Employee Voice on Social Media During COVID‐19
Authors: Khan Maria , Mowbray Paula K. , Wilkinson Adrian 
Published: January 2025

ABSTRACTExternal crises, such as the COVID‐19 pandemic, have increased job insecurity and overall uncertainty in the labour market. Crises like these can suppress employee voice; that is, employees may feel unable to express their ideas and opinions about their work, including dissatisfaction or criticism, because they may be worried about disagreeing with management and being seen as ‘rocking the boat’ in times of uncertainty. Nonetheless, this study finds that employees' desire to voice during the global pandemic led to them finding ways to speak up through social media (SM), with anonymity being a critical facilitator. Findings reveal that employees realised that SM affordances allowed them more agency over the agenda for voice regardless of prevailing voice norms. Despite open criticism not being well received by management, employees refashioned SM, which was primarily used for top‐down communication before the pandemic, into more of a bottom‐up voice mechanism. In doing so, we answer the call of researchers to explore the state of voice during a crisis and the potential of SM as a possible voice mechanism during such times.
Avoiding confusion: Modelling image identification surveys with classification errors
Authors: Spence Michael A. , Barry Jon , Bartos Thomas , Blackwell Robert , Scott James , Pitois Sophie 
Published: January 2025

Abstract

Automated systems driven by machine learning is becoming increasingly used as an environmental monitoring tool. A common approach is to use classification algorithms to identify counts of categories (e.g. species) from images. However, the classification algorithms can be biased in the presence of classification error. To draw valid conclusions, it is crucial to incorporate these errors into the analysis and interpretation of the classification algorithm results.

We introduce a general framework for describing counts with classification errors from classifiers, including data from both the classifier and a confusion matrix. The framework incorporates uncertainty in the classification matrix as well as uncertainty in the generating process. By treating the classification errors as latent variables, our framework allows a wide range of generating processes.

We illustrate our methods with three case studies based on simulated data from different generating processes, and data from a machine learning algorithm to identify zooplankton in the Celtic Seas and English Channel.

The framework is widely applicable in many subject areas where classification errors occur.
Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Authors: Pierret Aureliane C. S. , Patel Aaran H. , Daniels Elisabeth , Comninos Alexander N. , Dhillo Waljit S. , Abbara Ali 
Published: January 2025

AbstractThe hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and gametogenesis from the gonads. Many reproductive disorders in both males and females are characterized by hypothalamic dysfunction, including functional disorders (such as age‐related hypogonadism, obesity‐related secondary hypogonadism, hyperprolactinemia, functional hypothalamic amenorrhea and polycystic ovary syndrome), structural pathologies (such as craniopharyngiomas or radiation or surgery‐related hypothalamic dysfunction), and pubertal disorders (constitutional delay of growth and puberty and congenital hypogonadotropic hypogonadism). However, in many of these conditions, the relative contribution of hypothalamic dysfunction to the observed hypogonadism is unclear; as to date, there is no direct method of evaluating hypothalamic reproductive function in humans. Indeed, it is not possible to directly measure gonadotropin‐releasing hormone levels in the hypothalamo‐pituitary portal vessels, such that secondary (i.e., pituitary dysfunction) and tertiary (i.e., hypothalamic dysfunction) hypogonadism are often conflated as one entity. In this review, we examine the evidence for the use of kisspeptin as a method of directly evaluating hypothalamic reproductive dysfunction, and deliberate its potential future role in the evaluation of pubertal and reproductive disorders.
Highly hypofractionated biaxially rotational dynamic radiation therapy (BROAD‐RT) for high‐risk prostate cancer
Authors: Aizawa Rihito , Ogata Takashi , Goto Takayuki , Nakamura Kiyonao , Takayama Kenji , Ashida Ryo , Kita Yuki , Sumiyoshi Takayuki , Murakami Kaoru , Mizuno Kei , Kobayashi Takashi , Mizowaki Takashi 
Published: January 2025

AbstractTo report clinical outcomes following highly hypofractionated biaxially rotational dynamic radiation therapy (BROAD‐RT), a unique radiation therapy method that facilitates non‐coplanar volumetric‐modulated arc therapy (VMAT) without the need to rotate the couch or reposition the patient, for high‐risk prostate cancer (PCa) with simultaneous integrated boost (SIB) for intra‐prostatic dominant lesions (IPDLs), we performed a single‐center prospective pilot study. In this study, patients with high‐risk PCa according to the D'Amico classification or those with cT3aN0M0 PCa were eligible. VMAT was performed using BROAD‐RT, and a dose of 54 Gy in 15 fractions was prescribed for the prostate in combination with SIB for IPDLs at a dose of 57 Gy in 15 fractions. Short‐term neoadjuvant androgen‐deprivation therapy (median: 6.9 months) was conducted. Neither adjuvant androgen‐deprivation therapy nor fiducial marker implantation to the prostate was applied for any patient. In total, 26 patients were registered in this study between August 2018 and November 2020. Their median age was 73 years at the initiation of RT. The median follow‐up period was 49.7 months. The 4‐year cumulative incidence rates of grade 2 late GU and GI toxicities were 15.4 and 3.8%, respectively. No grade 3 or higher acute or late toxicities were observed. The 4‐year biochemical failure‐free survival rates were 87.7%. In conclusion, highly hypofractionated RT using BROAD‐RT for high‐risk PCa with SIB for IPDLs was feasible and facilitated favorable oncological outcomes. Therefore, this approach is considered a promising method to achieve safe dose escalation and shorten the treatment duration.
Knowledgebase‐Driven Exploration and Experimental Verification of Simvastatin's Inhibitory Impact on P2X7/NLRP3 Inflammasome Pathway
Authors: Wu Xinhai , Guo Chen‐Xin , Wang Sheng‐Feng , Gong Ting‐Ting , Yao Jing‐Wei , Hu Lin , Deng Zu‐Yue , Tang Lan , Xie Peng , Zhang Zan , Chen Yan 
Published: January 2025

ABSTRACTDepression is a mental health disorder and is the fourth most prevalent disease. Previous studies have suggested that statins are involved in the reduction of neuroinflammation. However, the potential mechanism for this relationship is unclear. The current study aimed to elucidate this by examining the effects of simvastatin on the P2X7/NLRP3 pathway in rats exposed to chronic mild stress (CMS). To achieve this goal, a depression database was first constructed, and simvastatin was used as an input to predict potential targets using machine/deep learning methods. Interestingly, the P2X7/NLRP3 pathway was predicted as a potential target for simvastatin. Subsequently, a depression rat model was established by inducing CMS for 4 weeks. Behavioral changes were detected via a sucrose preference test and forced swim test. The depression rats were then treated with simvastatin (10 mg/kg/day) for 14 days. Following treatment, changes in behavior and the activation of the NLRP3/ASC/caspase‐1 inflammasome pathway in the depression model rats were observed. The P2X7 agonist (ATP) and selective P2X7 antagonist brilliant blue G (BBG) were also used for in vivo intervention. Data from the experiment showed that treatment with simvastatin and BBG significantly reduced the depressive‐like behaviors in depression model rats, as well as the protein and mRNA expression levels of P2X7 and NLRP3 inflammasome. The protein and mRNA levels of the pro‐inflammatory cytokine interleukin‐1β significantly increased. These results demonstrate that simvastatin exerted an antidepressant‐like effect in the CMS model of rats, and this effect was dependent on the inhibition of the P2X7/NLRP3 inflammasome pathway.
Ovarian Endometrioma Disrupts Oocyte‐Cumulus Communication and Mitochondrial Function, With Melatonin Mitigating the Effects
Authors: Ge Lei , Yang Yali , Gao Yuqing , Xiao Tianxia , Chang Wakam , Wang Hefei , Xiao Zhonglin , Chen Jie , Li Mengxia , Yu Ming , Jin Ping , Zhang Jian V. 
Published: January 2025

ABSTRACTOvarian endometrioma (OEM), a particularly severe form of endometriosis, is an oestrogen‐dependent condition often associated with pain and infertility. The mechanisms by which OEM impairs fertility, particularly through its direct impact on oocyte‐cumulus cell (CC) communication and related pathways, remain poorly understood. This study investigates the impact of OEM on oocyte‐CC communication and explores melatonin's therapeutic potential. We used a mouse model of OEM and employed ovarian transcriptome and gene set enrichment analyses to identify disrupted gene pathways, alongside phalloidin staining for cytoskeletal analysis, gap junction coupling analysis for intercellular communication, and mitochondrial function assessments for cellular metabolism. Our results showed that OEM significantly impairs steroidogenesis and cumulus cell function, leading to increased apoptosis, disrupted transzonal projections (TZPs), and impaired antioxidant transfer to oocytes. This culminates in oxidative stress, mitochondrial dysfunction, and compromised ATP production. OEM oocytes also exhibited severe abnormalities, including DNA damage, maturation defects, spindle assembly disruptions, and increased aneuploidy. This study identifies disrupted TZPs as a key pathological feature in OEM and highlights melatonin's potential to restore intercellular communication, mitigate oxidative damage, and improve reproductive outcomes.
Multicenter prospective feasibility study on compliance, safety, and acceptance of small bowel and colon capsule endoscopy in the out‐of‐clinic setting in Japan
Authors: Ohmiya Naoki , Araki Akihiro , Tsuboi Akiyoshi , Nakamura Keiko , Ito Kyoko , Hotta Naoki , Kakugawa Yasuo , Oka Shiro , Saito Yutaka , Kato Tomohiro , Tanaka Shinji 
Published: January 2025

ObjectivesWe aimed to determine the compliance, safety, and acceptance of colon capsule endoscopy (CCE) and small bowel capsule endoscopy (SBCE) in an out‐of‐clinic setting remotely supported by medical staff.MethodsWe enrolled 30 examinees (24 with CCE and six with SBCE) who had not undergone CE at six gastroenterological centers. All examinees were provided with instructions on equipment and bowel preparations.ResultsCCE was performed at home (n = 16) or at the workplace (n = 8). Compliance with data‐recorder alerts was 100% for bowel preparation and 79% for equipment operation. Total capsule colonoscopy was achieved in 83.3%. The overall adequate endoscopic cleansing rate was 83.3%, and abnormalities, including colorectal polyps, were detected in 37.5%. CCE malfunction, such as the inability to automatically detect the small bowel mucosa occurred in one (4.2%). One experienced mild abdominal pain that required no treatment. Inquiries were present from half of the examinees. The proportions of examinees who desired and refused CCE at the next examination were 67% and 4%, respectively. SBCE was performed at home (n = 4) or at the workplace (n = 2). Compliance with the procedures was 100%. Whole small bowel images were recorded for all examinees. The overall adequate endoscopic clearness rate was 100%. One abnormality was detected. Inquiries were present from half of the examinees. There were no adverse events or malfunctions. The proportion of examinees who reported “quite easy” and “fairly easy” was 66%.ConclusionCCE and SBCE with all procedures in the out‐of‐clinic setting supported by remote consultations were feasible. A multicenter prospective study of the safety and acceptance of capsule endoscopy examinations at home (HomeCam‐J study) (jRCTs042220163).
Increased Non‐Relapse Mortality in Older People With Allogeneic Hematopoietic Stem Cell Transplantation Using Fludarabine and Myeloablative Dose of Busulfan‐Based Regimen
Authors: Shinohara Akihito , Shindo Michiho , Nakano Nobuaki , Sakaida Emiko , Uchida Naoyuki , Fukushima Kentaro , Nakazawa Hideyuki , Serizawa Kentaro , Kanda Yoshinobu , Kawakita Toshiro , Ikeda Takashi , Ohigashi Hiroyuki , Ito Ayumu , Wakayama Toshio , Matsuoka Ken‐ichi , Fukuda Takahiro , Tanaka Junji , Atsuta Yoshiko , Nakasone Hideki 
Published: January 2025

ABSTRACTFludarabine and myeloablative busulfan (FluBu4) in allogeneic hematopoietic stem cell transplantation (HSCT) for older people have not been adequately examined. This retrospective study analyzed data from a large‐scale, nationwide database in Japan. Adult patients (> 15 years old, y/o) who received their first HSCT with FluBu4 for hematological malignancies were included. They were categorized into the younger (< 60 y/o, N = 1295) and the older group (≥ 60 y/o, N = 993). The 3‐year overall survival (OS) rate after HSCT was significantly worse in the older group than in the other (p < 0.01, 39.9% vs. 48.5%). The 3‐year non‐relapse mortality (NRM) was significantly higher in the older group than in the other (p < 0.01, 30.9% vs. 23.0%), and the 3‐year cumulative incidence of relapse was comparable between them. According to the multivariate analysis, age ≥ 60 years was significantly associated with poor OS and high NRM. In a subgroup analysis of the older group, the use of additional chemotherapeutic drugs to FluBu4 was significantly associated with poor OS and high NRM. Total body irradiation was significantly associated with high NRM and 1‐year incidence of sinusoidal obstruction syndrome but not with OS. Thus, FluBu4 should be used with caution in older people.
Enhancing Faculty Well‐Being and Performance Through University Support: The Role of Resiliency and Proactive Personality in Remote Work
Authors: Kozhakhmet Sanat , Moghavvemi Sedigheh , Mazhiyeva Galiya 
Published: January 2025

ABSTRACTThe fast transitions of higher education to online format offers unique educational experience and practical knowledge that need to be considered by managers and policy makers. This paper aimed to explore the impact of organisational support practices on faculty members' in‐role performance and well‐being by assessing the mediating role of work resiliency capability and moderating role of proactive personality while working online and remote. Questionnaires were used to collect data from 390 faculty members from higher education institutions of Kazakhstan. The study found that work resiliency capability plays a mediating role in the connection between organisational support practices and faculty members' well‐being and in‐role performance. Additionally, it was discovered that the relationship between work resiliency capability and well‐being/in‐role performance negatively moderated by proactive personality. This research advances understanding of how universities can enhance the well‐being and in‐role performance of faculty working online and remotely.
High energy storage performance in ferroelectric ceramics (1−x)(0.67BiFeO3−0.33BaTiO3)−x(Sr0.8Ce0.1TiO3)
Authors: Gao Shaowei , Li Wei , He Xiang , Pang Dongfang 
Published: January 2025

AbstractIn this work, Sr0.8Ce0.1TiO3 (SCT) was doped into BiFeO3–BaTiO3 (BF–BT) to form a ternary solid solution with relaxor ferroelectric characteristics. Constricted P–E loops were observed due to the composition‐induced phase transition, and a significant grain size reduction was observed in the SCT‐doped ceramics. The elongated P–E hysteresis loops revealed that the ternary system had good energy storage characteristics. BF–BT–0.4SCT ceramics possessed the maximum recoverable energy storage (Wrec) of 1.94 J/cm3 and efficiency (η) of 76.1 % under an electric field of 190 kV/cm. More importantly, the BF–BT–0.4SCT ceramic exhibited excellent fatigue endurance (∆Wrec < 1.1%, after 103 fatigue cycles) under an electric field of 100 kV/cm, superior to most previous works. At the same time, the BF–BT–0.4SCT ceramic also showed high frequency stability, and fast discharge rate (t0.9 < .05 µs). In addition, the BF–BT–0.4SCT ceramic also exhibited considerable charging–discharging performance with a relatively high current density (127 A/cm2) and power density (5.8 MW/cm3). Therefore, this work helps broaden the development of BF‐based and other lead‐free ceramics for energy storage applications.
Rebuilding a DSS with feedback from behavioral and neuroscience studies
Authors: Barbosa Ferreira Evanielle , Rani Soares de Vasconcelos Tarsila , Reis Peixoto Roselli Lucia , Teixeira de Almeida Adiel 
Published: January 2025

AbstractAs the complexity of decisions and development technologies increase, decision support systems (DSSs) emerge to support decision‐making and improve the system's interaction with decision‐makers (DMs). Hence, this study seeks to show the modulations made in the FITradeoff (Flexible and Interactive Trade‐off) DSS, highlighting its flexible and interactive nature. These modulations have been made due to findings from behavioral and neuroscience studies conducted on the FITradeoff method and represent an important advance in research in the multicriteria decision‐making/aiding field. The study focuses on the main modulation made in the preference modeling process of the FITradeoff method, namely combining two paradigms for modeling preferences: elicitation by decomposition and holistic evaluation. Thus, the study discusses its implementation in the DSS, shows the flexibility this gives DMs, and highlights the two decision strategies presented in the holistic evaluation, that is, selecting the best alternative and eliminating the worst alternative.
Medication Management of Patients With Cancer Undergoing Surgery From Preadmission to Discharge: A Mixed‐Methods Systematic Review
Authors: Atefeh Mehrabifar , Elizabeth Manias , Patricia Nicholson 
Published: January 2025

ABSTRACTAim(s)To identify and synthesise available evidence about regular medication management processes, from preadmission to discharge from hospital, in patients with cancer undergoing surgery.DesignMixed‐methods systematic review.MethodsStudies published from inception of each database until February 2023 were screened, utilising four main search concepts. The JBI methodology for mixed‐methods systematic review was followed in this review.Data SourcesMEDLINE, CINAHL, EMBASE, APA PsycINFO, Scopus and Web of Science.ResultsEight out of 717 screened studies were included. Two themes related to patients' medication management were identified. Preoperative factors such as polypharmacy, potentially inappropriate medications, delirium‐inducing medications and preoperative discontinuation‐requiring medications were associated with several postoperative complications in patients with cancer. Additionally, pharmacist‐led interventions and collaborative efforts between nurses and patients were shown to improve the medication management process across the perioperative pathway.ConclusionThis systematic review emphasises the necessity of effectively managing regular medication, especially before surgery, to mitigate postoperative complications in patients with cancer. It offers critical insights into how involving pharmacists and nurses enhances medication management outcomes, benefiting health care professionals and institutions aiming to optimise perioperative medication therapy.Implications for the Profession and/or Patient CareEnhancing patients' regular medication management through comprehensive reviews before surgery, and improving collaborative practices among pharmacists, nurses and patients via targeted interventions introduced by health care organisations, ensure safe medication use throughout the perioperative pathway.ImpactImproving regular medication management process can reduce risk of medication errors and adverse drug events and enhance postoperative outcomes.Reporting MethodSWiM reporting guidelines.Patient or Public ContributionNo patient or public contribution.
Confucian Harmony, Civility, and Echo Chambers
Authors: van Oosterum Kyle 
Published: January 2025

ABSTRACTHow should we interact with people in echo chambers? Recently, some have argued that echo‐chambered individuals are not entitled to civility. Civility is the virtue whereby we communicate respect for persons to manage our profound disagreements with them. But for civil exchanges to work, people must trust one another and their testimony. Therefore, some argue, we can be moderately uncivil toward those in echo chambers who are unlikely to trust our attempts to be civil. I argue against this position. I suggest the focus should be on trying to rebuild these social relationships in alignment with the Confucian value of harmony. In this tradition, we aim to manage social relationships with disagreeable others by turning inward and cultivating certain dispositions in ourselves: open‐mindedness, amenability, tactfulness, and courage. I argue this helps us craft a concept of ‘reparative civility’: an ideal for managing our fraught social relations in a world of echo chambers.