bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Musa Paradisiaca Activated Carbon Supporting Iron Nanoparticles, after Adsorption of Hydrogen Sulphide (H2S) from Biogas on a Fixed Bed Column
Authors: KONAN GBANGBO Rémis , ADJOUMANI KOUAKOU Rodrigue , DONATIEN EHOUMAN , YAO Benjamin , LOU Gonézié Vanessa-Edwige GOLI , GOUESSE Briton Bi Henri , GNABOA Tougnon Zéphirin , BAH Koffi Née Alphonsine Badou Affoua , KIARI Mahamane Nassirou AMADOU 
Published: February 2023

Abstract
In this study, the characteristics of Musa Paradisiaca (MP) iron-funtionalysed activated carbon (AC) after adsorption of H2S from biogas were demonstrated. The AC was chemically impregnated with potassium hydroxide (KOH) and then carbonised at a temperature of 500°C for 3 hours for activation. The activated carbon was then functionalized with iron oxide (Fe2O3) and labelled BANK-Fe. The H2S adsorption test was performed on a fixed bed column. The biogas flow rate was 1 L.min− 1. with 25% water (w/w) added. This test resulted in an adsorption capacity of 9.86 mgH2S.g-1 after a saturation time of 615 minutes. This was satisfactory for the purposes of biogas treatment. The present work is a follow-up to the adsorption tests already carried out. The analyses on the functionalized activated carbon sample after adsorption underwent a physical and chemical change. The surface morphology was modified: the more or less homogeneous asperities of the BANK-Fe (before adsorption) gave way to a relatively more amorphous form. Sulphur elements were detected in the sample after adsorption, in contrast to the starting sample. This confirms the adsorption of H2S from the biogas. Oxygen and Iron in BANK-Fe decreased by 39.49% and 94.16% respectively in atomic concentration, which proves that they reacted and played a role in the H2S adsorption mechanism. In addition, the microporosity decreased by 35.71%: the iodine value decreased from 1065.96 mg.g− 1 to 685.26 mg.g-1. This indicates that part of the pores, in particular the micropores, was occupied by the pollutants during the adsorption of the biogas.
Renal Glucose Transporters Play a Role in Removal of Cadmium from Kidney Cells Mediated by GMDTC – A Novel Metal Chelator
Authors: Tang Xiaojiang , Chen Xushen , Xiao Bo , Zhao Qile , Hu Wei , McKenery Amber , Zhong Zhiyong , Ren Xuefeng 
Published: February 2023

Abstract
Cadmium (Cd) is a toxic heavy metal, exposure to which leads to various adverse health effects including chronic kidney damage. Tremendous efforts have been explored in identifying safe chelating agents for removing accumulated Cd from kidney, but with limited success owing to their associated side effects and the ineffectiveness in eliminating Cd from the body. A newly developed chelating agent, sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl) amino)-4(methylthio)butanoate (GMDTC), has been shown to effectively mobilize Cd from kidney. However, the mechanism(s) of removal are unclear, while it has been hypothesized that renal glucose transporters potentially play key roles mainly because GMDTC contains an open chain glucose moiety. To test this hypothesis, we utilized the CRISPR/Cas9 technology and human kidney tubule HK-2 cells, and constructed sodium-dependent glucose transporter 2 (SGLT2) or glucose transporter 2 (GLUT2) gene knockout (KO) cell lines. Our data showed that GMDTC’s ability in removing Cd from HK-2 cells was significantly reduced both in GLUT2-/- or SGLT2-/- KO cells, with a removal ratio reduced from 28.28% in the parental HK-2 cells to 7.37% in GLUT2-/- KO cells and 14.6% in SGLT2-/- KO cells. Similarly, knocking out the GLUT2 or SGLT2 gene led to a compromised protective effect of GMDTC in reducing cytotoxicity of HK-2 cells. This observation was further observed in animal studies, in which the inhibition of GLUT2 transporter by phloretin treatment resulted in a reduced efficiency of GMDTC in removing Cd from the kidney. Altogether, our results show that GMDTC is safe and highly efficient in removing Cd from the cells, and this effect is mediated by renal glucose transporters.
The association between childhood adversity and the conserved transcriptional response to adversity (CTRA) in sexual minority men
Authors: Dalvie Shareefa , Li Michael , Kalmin Mariah , Cole Steven , Stein Dan Joseph , Shoptaw Steven 
Published: February 2023

Abstract
Adverse childhood experiences (ACES) increase risk for mental and physical health disorders in adulthood, particularly in individuals from sexual and ethnic minority groups. The effects of ACES on health may be mediated by the immune system. The exact mechanisms by which an environmental exposure, such as childhood adversity, can affect the immune system are still unknown. The aim of this study was to determine whether early adversity predicts significant changes in the expression of a predefined set of immune–related genes, known as the conserved transcriptional response to adversity (CTRA), in a diverse group of sexual minority men (SMM). Participants included HIV positive and negative males from the mSTUDY. Expression data from 53 CTRA genes were obtained at baseline and 12-month follow-up. Childhood adversity was measured with the 10-item ACES questionnaire. Wilcoxon rank sum and chi-squared tests were used to assess differences in sociodemographic variables and HIV status between exposed (cumulative ACES ≥ 3) and unexposed groups (cumulative ACES ≤ 2). Linear mixed models were used to determine associations between ACES (cumulative score, dichotomous measure and subscales) and CTRA gene expression. There were no differences in age and employment status between the exposed and unexposed groups. A larger number of exposed participants were HIV positive than in the unexposed group (p = 0.03). There were no significant associations between any of the ACES variables and CTRA gene expression. A range of factors may have contributed to this unexpected finding. Further studies are needed to assess the biological effects of ACES in adulthood.
Land use and damaging hydrological events temporal changes in the Sarno River basin: potential for green technologies mitigation by remote sensing analysis
Authors: Mobilia Mirka , Longobardi Antonia , Amitrano Donato , Ruello Giuseppe 
Published: February 2023

Abstract
The urban growth leads cities to adopt sustainable strategies in order to mitigate the relevant hydrological effects. In this study, the use of synthetic aperture radar SAR imagery has allowed us to demonstrate a 70% increase of the built-up area in Sarno River basin between 1995 and 2016. This increase is linked to the statistical temporal increase of the damaging hydrological events occurring during the same period. To restore the pre-development hydrological condition, a scenario analysis was undertaken where SWMM was used to simulate the hydrological effect of green roof retrofitting landscape design. SAR imagery was furthermore used to explore the potential retrofitting surfaces, leading to defining three different conversion scenarios with 5%, 30% and 100% of potential retrofitting surfaces. The study demonstrated that the pre-development hydrological condition can be never fully restored. Indeed, this scenario is partially equaled only by a 100% green conversion of the existing traditional roofs, with average runoff and peak flow reduction of 41% and 25%, respectively. Such conditions are clearly not feasible, provided the obvious retrofitting limitation for existing buildings. The use of additional nature-based techniques, beyond green roofs conversion, should be explored in the perspective of a balance for urban growth.
Minimum night flow (MNF) and corrosion control in compliance with internet of things (IoT) for water systems
Authors: Hariri Asli Kian , Hariri Asli Kaveh 
Published: February 2023

Abstract
In the new world view, water is considered an economic-social commodity and a basic human need. This work aims to investigate the relationship between corrosion and changes in the minimum night flow (MNF) rate in water systems. Changes in MNF as a dependent variable are affected by changes in independent variables such as total unreported water loss, allowed night consumption, and network field leakage. First of all, the share of water loss due to network corrosion in total unreported water loss was investigated through a mathematical model and regression analysis according to Geography Information System (GIS). As a result, the p-value for pressure was .564. The Power function had a suitable correlation on the scatter diagram and best-fit curve which was used for Inflow to the water distribution network based on the regression model. The error of the consumers' meter and the correction of these errors were discussed in the apparent water loss section. The apparent water loss value was equal to 1.12% of produced water. This amount of apparent water loss showed the share of the actual water loss due to network corrosion from the total unreported water loss in the facilities.
Novel Perspectives for the Diagnosis and Treatment of Gynecological
Cancers using Dysregulation of PIWI Protein and PiRNAs as
Biomarkers
Authors: Yousefi Bahman , Sadoughi Fatemeh , Asemi Zatollah , Mansournia Mohammad Ali , Hallajzadeh Jamal 
Published: February 2023

Abstract:
The term “gynecological cancer” is used for a group of cancers occurring in the female reproductive system. Some of these cancers are ranked as the leading causes of death in developed and developing countries. The lack of proper diagnostic strategies is one of the most important reasons that make them lethal. PIWI-interacting RNAs or piRNAs are a class of small non-coding RNAs, which contain 24-32 nucleotides. These RNAs take part in some cellular mechanisms, and their role in diverse kinds of cancer is confirmed by accumulative evidence. In this review, we gather some information on the roles of these RNAs and members of the PIWI protein family to provide new insight into accurate diagnostic biomarkers and more effective anti-cancer drugs with fewer side effects.
Aptamers-based Strategies for the Treatment of Microbial Infections
Authors: Di Rienzo Annalisa , Marinelli Lisa , Di Stefano Antonio , Vicaretti Giuseppina , Cacciatore Ivana 
Published: February 2023

Background:
Nowadays, infectious diseases caused by bacteria are one of the major risks for
the human population worldwide. Antimicrobial resistance determined the necessity to develop both, new
drugs and therapeutic approaches as alternatives to antibiotics and novel methods to detect bacteria. Aptamers
have revealed their potential in combating antimicrobial infections. Aptamers are small singlestranded
DNA or RNA oligonucleotides obtained through an in vitro process able to bind several targets
with high affinity and specificity.

Objective:
The aim of this review is to provide an overview of the state of the art of aptamer-based antimicrobial
therapeutic strategies, new methods of detection of bacteria, and their potential use as delivery
systems.

Conclusion:
Recent applications on research about aptamers suggest their important potential in discovering
novel pharmacological tools for the treatment of microbial infections.
Autologous CD19-Targeted Chimeric Antigen Receptor (CAR)T-Cells as
the Future of Systemic Lupus Erythematosus Treatment
Authors: Kambayana Gede , Surya  Rini Sandra 
Published: February 2023

Abstract:
Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with an unclear eti-ology and a range of clinical manifestations. The therapeutic results of current conventional treat-ments are frequently unsatisfactory. Many B-cell-directed immunotherapies have recently been dis-covered, as B cells play a key role in the pathogenesis of SLE. However, large-scale rituximab trials found that the antibody against CD20 was no better than a placebo. Autologous CAR T-cell therapy has garnered considerable interest and is considered a potential treatment option for SLE. CD19+CD20- B cells are thought to play an essential role in the onset and progression of SLE. CD19-targeted CAR T-cells destroy B cells without requiring an accessory cell type, thereby de-creasing B cells more efficiently. Preclinical trials of CAR T-cells in mice have shown promising results against SLE. The review aimed to shed light on autologous CD19-targeted CAR T-cells as a potential treatment for SLE.
Impact of Thread-based Microfluidic Devices in Modern Analysis: An
Update on Recent Trends and Applications
Authors: Ahlawat Sanskar , Bhatia Rohit , Kumar Bhupinder 
Published: February 2023

Background:
Inexpensive and disposable microfluidic sensing equipment is in strong demand
which can detect biomarkers of diseases found in urine or blood. From recent studies, it has been found
that multifilament threads can be used for producing low-cost microfluidic devices hence these multifilament
threads act as an inexpensive alternative. Thread has various advantages to make it appropriate to be
used in microfluidics-based technologies which include its low price, lightweight, easy availability, and
hydrophilic nature. The use of any external pumping system is avoided by the presence of capillary channels
in threads which allows the easy flow of fluid. Since thread offers more choices of materials over
paper and also paper-based microfluidics preparation is expensive therefore thread-based microfluidic
sensor has been considered more advantageous over paper-based microfluidic sensors.

Methods:
Various research reports were collected from search engines like ScienceDirect, Pub-med, ResearchGate,
and Google Scholar. Further important outcomes from these reports along with basic experimental
setup details have been compiled under different sections of this manuscript.

Conclusion:
Non-invasive or blood-free diagnosis can reduce the pain and several risk factors compared
with the traditional invasive diagnosis so it is gaining more attention regarding health status monitoring.
The various applications regarding thread-based devices include the detection of glucose and its determination,
diagnosis of diabetes and kidney failure simultaneously, food dyes separation, sweat pH and lactate
determination, selective potassium analysis, multiple antibodies detections, an assay of microbes, for
acid-base titrations, as ELISA’s platform, diagnosis of infectious diseases, ion sensing, identification of
blood types and detection of bio-samples, etc.
Gold Nanoparticles and Wound Healing in Rodents: A Systematic Study
Authors: Dehghan Hamideh , Sedighi Mahsa , Jafari-Nozad Amir Masoud , Jafari Shima , Alemzadeh Esmat , Farkhondeh Tahereh , Samarghandian Saeed 
Published: February 2023

Background:
Wound healing remains a challenge that has not yet been solved. Researchers
are more interested in gold nanoparticles (AuNPs) than other nanoparticles because of
their size-related chemical, electrical, and magnetic properties that may be useful in biological
applications. Due to their antioxidant, anti-inflammatory, antibacterial qualities, and their capacity
to destroy free radicals, AuNPs are also advantageous in lowering inflammation and promoting
quicker wound healing.

Method:
In this study, we analyzed all pertinent papers up to April 2021 to study the impact of
AuNPs on the wound healing process in animal experiments based on scientific data, as wound
healing is still one of the most significant medical difficulties. Based on the keywords "Gold,
Nanoparticles, and wound healing," we carried out a systematic evaluation of the literature in
PubMed, Ovid Medline, Google Scholar, Scopus, and Web of Science databases.

Result:
This analysis shows that in all 13 studies reviewed, AuNPs significantly accelerated
wound healing, decreased wound size, and produced complete epithelialization.

Discussion:
AuNPs reduced inflammatory factors at the location of the lesion. Additionally,
groups exposed to AuNPs showed an increase in connective tissue as well as an increase in the
deposition of collagen in the wound. Different events such as the production of hair follicles,
angiogenesis, antioxidant, and antibacterial actions of AuNPs have also been observed in the
healing process of wounds. AuNPs are auspicious substances that may offer a therapeutic option
for treating wounds.

Conclusion:
To validate these results, however, an additional large sample of experimental human
research is required.
Cardiac Injury Following Chemo/Radiation Therapy: An Updated Review
on Mechanisms and Therapeutic Approaches
Authors: Singh Krishanveer , A. Alameri Ameer , Ali Hamza Ammar , E. Al-Gazally Moaed , Temurovich  Islomov Sarvar , Fadhel Obaid Rasha , Alexis  Ramírez-Coronel Andrés , Abosaooda Munther , Yahyapour Rasoul , Najafi Masoud 
Published: February 2023

Abstract:
Cardiovascular disorders are among the critical side effects of cancer therapy. Damage
to the function and normal structure of the heart can cause serious threats to patients that are being
treated for cancer. Cardiovascular complications may be induced by various types of chemotherapy
drugs and also radiation therapy. The severity of cardiovascular toxicity depends on several
factors, such as types of drugs, tumor location for radiotherapy, the presence of cardiac disease
history, the dose of drugs or ionizing radiation, etc. Radiotherapy and chemotherapy can cause
heart diseases through various mechanisms, such as oxidative stress, inflammation, cell death, fibrosis,
endothelial to mesenchymal transition (EndMT), etc. Chronic inflammation following
damage to a huge number of cells can trigger more accumulation of inflammatory cells and chronic
release of reactive oxygen species (ROS) and nitric oxide (NO). Oxidative stress can induce
more cell death and cardiac remodeling through damage to vessels and valvular and disruption of
the normal structure of the extracellular matrix. These changes may lead to cardiomyopathy, myocarditis,
pericarditis, and vascular disorders that may lead to heart attack and death. This review
provides basic information on cellular and molecular mechanisms of different types of cardiovascular
disorders following cancer therapy by radiation or chemotherapy. We also recommend some
adjuvants and targets to reduce the risk of heart toxicity by radiation/chemotherapy.
Hydroalcoholic Extract of Achillea Wilhelmsii Decreases the Expressions
of Hippo Signaling Pathway-Associated Oncogenes in the A549 Lung
Cancer Cell Line
Authors: Nabatchian Fariba , Davoudi Maryam , Ashtiani Mojtaba , Davoudi Negin , Afrisham Reza 
Published: February 2023

Background:
Achillea wilhelmsii used in traditional Iranian medicine to treat a variety of
disorders, has been proven to contribute to some signaling pathways in cancers. Evidence suggests
that the Hippo pathway, which regulates organ size, is altered in a few conditions like lung cancer. In
this regard, this study aimed to evaluate the effect of the hydroalcoholic extract of this plant on the viability
and mRNA expression of some Hippo signaling pathway-associated oncogenes and suppressors
in A549 lung cancer cell lines.

Methods:
Hydroalcoholic extract was prepared using a Soxhlet extractor and its antiproliferative activity
was studied by MTT assay. Then, the mRNA expressions of "large tumour suppressor kinases 1
and 2" (LATS1 and LATS2), "Yes1 Associated Transcriptional Regulator" (YAP1), and "Transcriptional
co‑activator with PDZ‑binding motif" (TAZ) were measured using real-time PCR.

Results:
According to MTT, the viability was decreased significantly after 24 h treatment with A. wilhelmsii
at the concentrations of 800-1000 μg/ml and after 48 h treatment at the concentration of 400-
1000 μg/ml. While the mRNA levels of LATS1, TAZ, and YAP1 decreased significantly compared to
untreated cells at the concentration of 200 μg/ml after 48 h treatment. However, the mRNA expression
of LATS2 did not change.

Conclusion:
Our findings showed that hydroalcoholic extract of A. wilhelmsii inhibited the viability of
lung cancer cells as well as it could decrease the expression of both oncogenes in the Hippo pathway.
However, it had suppressing effects on LATS1, which should be considered in further studies.

conclusion:
Hydroalcoholic extract of A. wilhelmsii might inhibit proliferation of lung cancer cells as well as it could decrease the expression of both oncogenes in them. However, it had suppressing effects on LATS1, which should be considered in further studies.
Microelements in seeds of advanced genotypes of Caupí beans (<em>Vigna unguiculata</em> L. Walp) established in a soil of Cordoba, Monteria.
Authors: Quiñones Avilés María , Argel Espitia María , Combatt Caballero Enrique Miguel , Aramendiz Tatis Hermes , Mercado Lázaro Jaime 
Published: February 2023

The objective was to quantify the nutritional contents in seeds of different advanced genotypes of cowpea bean (Vigna unguiculata L. Walp) in the soil of Montería-Córdoba, Colombia. Seeds of 40 lines or genotypes and two commercial varieties Caupicor 50 and ICA Betancí were evaluated as controls. A completely randomized block design was used with three repetitions for a total of 126 experimental units. The seeds were initially subjected to drying in a forced circulation oven at 70 ° C for 72 hours to quantify the nutritional content. The final nitrogen content was evaluated by initially submitting the seeds to digestion in concentrated sulfuric acid for 4 hours. It was subsequently quantified using the Kjeldahl method. Finally, to determine the content of microelements, 1 g of seed was subjected to digestion with nitric, perchloric acid (3:1), and they were quantified in a piece of atomic adsorption equipment. With the information recorded in the laboratory, an analysis of variance, contrasts, and tests of Tukey averages was performed at a 5% probability. The results indicate that it existed genetic variability and genotypes LC-041-016 and LC021016 were identified with 29.2 and 29.1%, with the highest protein content, being superior to Caupicor 50 and ICA Betancí that presented contents of 25, 7 and 25.5%. The genotypes L-047 with 216.3, followed by genotypes LCPM35 and LC027016, with 159.5 and 127.3 mg.kg-1 presented the highest iron content, and the commercial witnesses Caupicor 50 and ICA Betancí, content less than the above, and the content zinc and manganese were similar in all genotypes evaluated.