bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unravelling the Thermo-Physical Properties of MHD Heat and Mass Transfer of Nano-Fluid Flow over a Nonlinear Permeable Stretching Sheet
Authors: Ekang Idongesit F. , Popoola Amos O. 
Published: July 2023

Abstract
Investigating MHD Heat and mass transfer of Nano-fluid over a permeable stretching sheet can lead to improved storage, handling and usage. This work therefore examined the significance of temperature-dependent viscosity and temperature-dependent thermal conductivity on MHD heat and mass transfer of nano-fluid over a nonlinear permeable stretching sheet. The governing partial differential equations describing the nano fluid flow are transformed and parameterized into a system of ordinary differential equations. The resulting mathematical model was solved numerically using shooting technique with fourth order Runge-Kutta method after the transformation by similarity technique. Graphical analysis is conducted to investigate the impact of certain fluid parameters on the momentum, thermal and concentration equations. The results from the graphs showed that temperature-dependent viscosity and temperature-dependent thermal conductivity have appreciable effect on the model.
2010 AMS Subject Classification: 76D05, 76W05
Fluids and body composition during anesthesia in children: a bioimpedance study
Authors: Betti Céline , Busi Ilaria , Cortesi Cinzia , Anselmi Luciano , Mendoza-Sagaon Mario , Simonetti Giacomo D. 
Published: July 2023

Abstract
PURPOSE: The assessment of total body fluid volume, intracellular volume and extracellular volume before and after anesthesia may be useful to define a better intraoperative fluid administration.
METHODS: A bioimpedance spectroscopy device (BCM) was used to measure total body fluid volume, extracellular volume, intracellular volume. BCM-measurements were performed before and after general anesthesia in unselected healthy children and adolescents visiting the Pediatric Institute of Southern Switzerland for low-risk surgical procedures.
RESULTS: In 100 children and adolescents aged 7.0 [4.8 – 11] years (median and interquartile range), the average total body water (TBW) increased perioperatively with a delta value of 182 [0 – 383] mL/m2 from pre- to postoperatively, as well as the extracellular water content (ECW), which had an equivalent increase with a delta value of 169 [19 – 307] mL/m2. The changes in TBW and ECW significantly correlated with the amount of fluids administered.
CONCLUSIONS: This preliminary report shows that intraoperative fluid administration results in a significant fluid accumulation in low-risk schoolchildren during general anesthesia. Children without major health problems undergoing short procedures, do not need any perioperative intravenous fluid therapy, because they are allowed to take clear fluids up to 1 hour prior anesthesia. BCM-measurements could become useful for guiding intraoperative fluid therapy in future studies.
Reduction of gas and oil pipeline failures using radiography inspection technique
Authors: Mbizani Vusumuzi Samuel , Mathuthu Manny 
Published: July 2023

Abstract
The oil and gas sector faces a challenging predicament as the recurring issue of pipeline failures impedes progress. One such setback arises from corrosion that stems from Fe2+ Carbon steel pipelines. This corrosion leads to equipment wearing out prematurely, leading to potential environmental hazards caused by product leakages. This study investigated pipelines failures using radiography inspection method. Results showed that the smaller the pipe thickness, the higher the corrosion rate and a welding is likely to break where it failed before. This work confirmed that routine maintenance of pipelines is key to reducing product losses and environmental pollution with oil or gas leakages.
A spatiotemporal prediction model for surface subsidence caused by mining in deep loose and thin bedrock strata
Authors: Qin Zhe , Han Xu , Han Jihuan 
Published: July 2023

Abstract
Aiming at the shortcomings and limitations of existing prediction methods and time function models in predicting the surface subsidence caused by coal mining in deep loose and thin bedrock strata, the deformation and mechanics characteristics of mining rock are analyzed comprehensively, and a near rectangular deflection function is established based on determining the spatial position of the primary key layer. Combining with the principle of probability integral method of discontinuous random medium, a spatiotemporal prediction model(SPM) is obtained to depict the development of surface subsidence throughout coal mining process, and its reliability is verified. The results demonstrate that the model can accurately invert the whole process of surface subsidence with coal mining, providing reliable outcomes. The model considers various factors relevant to coal mining, contributing to its theoretical significance. Additionally, the utilization of visual programming operations enhances the practicality and convenience of the model in engineering applications. The results are of great significance for the prevention and control of stratal subsidence disasters resulting from mining activities.
Recognizing Risk Factors of Breast Cancer Development and Evaluating the Efficacy of Mammography Screening in Taiwan
Authors: Huang Chi-Cheng , Lu Tzu-Pin , Wang Yu-Jen , Chen Bo-Fang , Yang Hui-Ting , Chang Wei-Pin , Tseng Ling-Ming 
Published: July 2023

Abstract
Background
Evidence of mammography screening primarily came from Western countries, while there remains an unmet need for a more efficient and tailored screening strategy.
Purpose
Risk factors for breast cancer development were identified from big data analyses.
Methods
Using a unique ID, we identified subjects attending screening at least once between Jan 2007 and Sep 2014, matching the cancer registry concurrently with a two-year’s extension of the screening interval to Aug 2016.
Results
Multi-variate analyses identified family history of cancer, the number of affected sisters, years of hormone replacement, breast symptoms, breast examinations within two years, previous breast surgery, educational level, and breast composition as risk factors for breast cancer diagnosis, while menopausal status, breast feeding, sonography within two years, compared with previous mammography, times of screening mammography, and served with a mobile mammography van were protective. The model showed an area under the receiver operating characteristic curve of 0.6766. Screening-detected cases were associated with an earlier disease stage, while clinically detected breast cancer remained an independent risk factor for relapse-free and overall survival.
Conclusion
Using big data analysis for risk model construction, several risk factors for Taiwanese breast cancer development were identified, and the efficacy of mammography screening was ascertained for Taiwanese women.
Impact:
Further studies incorporating genetic data may augment the predictive power substantially and pave the way for personalized screening.
Adaptive resource allocation for time-critical applications in industrial edge computing using Heuristic-HCMDO approach
Authors: K Udayakumar , S Ramamoorthy 
Published: July 2023

Abstract
An intensive computation source has become increasingly important in recent years to meet the time-critical and low-latency needs of Industrial Internet of Things (IIoT) systems. Existing IIoT-based devices are built with limited computational resources, delivering results in a limited fashion when used in highly resource-intensive applications. Since then, a novel concept known as Edge Computing (EC) has been introduced to reduce network latency and alleviate strain on cloud data centers using an EC server located at the network's periphery. The EC server only managed to gather a small number of resources compared to the resource cloud. Without prior context about task deadline and load, an EC server could not optimally handle latency-sensitive and computation-intensive tasks. Additionally, the EC server did not significantly improve overhead minimization when sending data to and from the remote cloud and the user's device. Parallel to the development of EC, nonorthogonal multiple access (NOMA) has been identified as a technique with the potential to substantially increase spectrum efficiency. In this paper, a NOMA-based EC framework for IIoT system is examined, in which multiple task nodes transfer their task via NOMA to multiple edge servers in proximity for execution. As such, this paper aims to develop a joint optimization model for making decisions about task offloading and allocating resources in Industrial edge computing. An adaptive resource allocation decision model (ARADM) based on deep reinforcement learning (DRL) and heuristically modified long short-term memory (H-LSTM) using hybrid Cat and Mouse Dingo Optimization (HCMDO) is proposed to allocate the task optimally. We formulate joint optimization by considering multi-constraint objective function with communication, computation, and cache parameters using HCMDO. Further, these optimal parameters are used in training an H-LSTM along with benchmark dataset. The outcome of the H-LSTM network utilized in DRL to improve convergence speed, accuracy and stability by predicting optimal cost and load. The goal is to minimize service delay, energy consumption, balance load and maximize resource utilization. The experimental results validated the developed model and its ability to improve the quality of resource allocation in Industrial edge computing.
Urban refugia sheltering biodiversity across world cities
Authors: Gentili Rodolfo , Quaglini Lara Assunta , Galasso Gabriele , Montagnani Chiara , Caronni Sarah , Cardarelli Elisa , Citterio Sandra 
Published: July 2023

Abstract
Over the last years, world cities have emerged as multiple and complex habitats hosting numerous and varied urban refugia for biodiversity. Therefore, the published literature was systematically reviewed to investigate the increasingly acknowledged role of many urban habitats to function as refugia for species. Many plants and animals were reported to colonize a variety of urban environments: Urban forest/grassland (natural/seminatural), City park, Historical park (villa garden, botanical gardens, cemeteries, etc.), Green spaces (abandoned areas, railways, line of trees, etc.), Water body, and Built areas. Refugia were found in over a hundred world cities, especially in medium- to very big-size cities. The number of papers focusing on animals (n=66) were higher than those regarding plants and mushrooms (n=19 and n=1, respectively); however, the number of species recorded within refugia were the highest for plants. Plants exhibited the highest frequency (7 out of 19 papers) in Historical park, while animals in Urban forest and grassland (20 out of 66 papers). In most studies (25.9%), urban refugia were linked to Urban forest/grassland that is terrestrial natural and seminatural sites widespread within or around cities. The 22.3% of studies referred to generic Green spaces of several types interspersed within cities, both public and private. The 14.1% of refugia were found in Built areas (artificial). About the 33% of studies reported the presence of species worthy of conservation (rare, endemic, endangered, or protected) for a total of 365 species. The 20% of investigated papers reported the presence of alien species for a total of 879 species. The capability for urban areas to host a huge amount of biodiversity needs to be acknowledged by city planners so that management practices that maintain and support such diversity can be pursued. Recording and monitoring species along with their refugial habitats is fundamental to achieve this goal.
Biomass, Productivity, Carbon Sequestration and Economics of four short rotation tree Species in Eastern part of Uttar Pradesh
Authors: Tomar Anita , Singh Bijay Kumar 
Published: July 2023

Abstract
To study the biomass, productivity, carbon sequestration and economic of short rotation tree species viz., Eucalyptus spp., Casuarina equisetifolia, Gmelina arborea and Melia dubia in high-density plantation in Prayagraj, Uttar Pradesh, India, with different spacings, viz., 1 × 1 m, 1.2 × 1.2 m and 1.5 × 1.5 m. The experiment was established in July 2019 and data was collected every year. The maximum volume was found in T1: Eucalyptus (1×1 m) 2917.34 m3 ha-1 followed by T4: Melia (1×1 m) 2109.74 m3 ha-1 and minimum in T10: Casuarina (1.5×1.5 m) 373.54 m3 ha-1. The Biomass, Carbon Stock and Carbon Sequestration maximum found in T1: Eucalyptus (1×1 m) 3374.43, 1687.22 and 6192 t ha-1 followed by T4: Melia (1×1 m) 1594.96, 797.48 and 2926.75 t ha-1 and minimum in T12: Melia (1.5×1.5 m) 406.58, 203.29 and 746.07 t ha-1 respectively. The maximum volume productivity index was found in T1: Eucalyptus (1×1 m) 833.53 m3 ha-1 year-1 followed by T4: Melia (1×1 m) 602.78 m3 ha-1 year-1 and minimum in T10: Casuarina (1.5×1.5 m) 106.74 m3 ha-1 year-1 whereas the maximum biomass productivity index was found in T1: Eucalyptus (1×1 m) 964.12 t ha-1 year-1 followed by T4: Melia (1×1 m) 455.70 m3 ha-1 year-1 and minimum in T12: Melia (1.5×1.5 m) 116.18 m3 ha-1 year-1. The maximum B:C ratio was found in T1: Eucalyptus (1×1 m) 8.35 followed by T9: Eucalyptus (1.5×1.5 m) 5.03 and minimum in T3: Casuarina (1×1 m) 2.06.
Weizmannia coagulans Extracellular Proteins Reduce Skin Acne by Inhibiting Pathogenic Bacteria and Regulating TLR2/TRAF6- Mediated NF-κB and MAPKs Signaling Pathways
Authors: Zhang Yongtao , Jiang Yanbing , Zhao Jingsha , Mo Qiuting , Wang Changtao , Wang Dongdong , Li Meng 
Published: July 2023

Abstract
As a probiotic, Weizmannia coagulans (W. coagulans) is often used in food and medicine to regulate intestinal flora and resist specific inflammation. In this study, the anti-acne efficacy and mechanism of YTCY extracellular proteins (YTCY-EPs) from a strain of W. coagulans are analyzed. The main components of YTCY-EPs, extracted and separated from the fermentation broth, are peptides ranging from 1.51–11.44 kDa, accounting for about 80%. Among the peptides identified by LC/MS-MS, YTCY A-F possess the properties of antimicrobial peptides, while YTCY 1–4 possess antioxidative properties. These peptides have a strong effect on Cutibacterium acnes (C. acnes) and significantly inhibit Staphylococcus aureus. The adhesion of YTCY-EPs has a 50% inhibition rate. It is found that YTCY-EPs possess strong antioxidant and anti-inflammatory properties, and can reduce the downstream TLR2/NF-κB and MAPKs/AP-1 pathways by regulating the nuclear translocation of NF-κB and AP-1 in vitro. The transcriptional expression of inflammatory cytokines, inflammatory chemokines, and matrix metalloproteinase genes is also regulated, thereby slowing the recruitment of inflammatory cells and the development of inflammation, and increasing keratinocyte mobility. YTCY-EPs can also effectively solve such problems as erythema, papules, cysts, skin lesions, hyperkeratinization, and desquamation caused by C. acnes in rabbit ears. Additionally, the treatment effectively improves the condition of wounds and inflammation. The results of this study prove that YTCY-EPs can be used as a potential anti-acne raw material in cosmetics.
Causal association between type 1 diabetes mellitus and inflammatory bowel disease: A two-sample bidirectional Mendelian randomization study
Authors: Su Tao , Gan Ying , Ma Shulin , Lu Shilin , Zhi Min , Dai Shixue , Yao Jiayin , Lu Yi 
Published: July 2023

Abstract
Background: Type 1 diabetes mellitus (T1DM) and inflammatory bowel disease (IBD) are common autoimmune diseases. Previous studies reported an association between these two diseases. However, due to the limitations of observational research, it cannot provide sufficient evidence to support the existence of causality or reverse causality.
Objective: This study aimed to evaluate the existence of the causal relationship between T1DM and IBD.
Methods: A two-sample bidirectional Mendelian randomization (MR) was employed to investigate a possibility of the causal relationship between T1DM and IBD, including Crohn's disease (CD) and ulcerative colitis (UC). Independent genetic variants of T1DM and IBD were retrieved from the IEU OpenGWAS project，and the individuals were of European ancestry. After filtering the single nucleotide polymorphisms (SNPs), several MR methods, including MR–Egger regression, weighted median, inverse variance-weighted (IVW), and weighted mode with IVW as the primary analysis method, were used to test the causal association between the two diseases. Furthermore, a sensitivity analysis was conducted to detect the heterogeneity and pleiotropy of the instrumental variables.
Results: Bidirectional MR analysis indicated a negative correlation between T1DM and IBD (IVW OR: 0.95, 95% Confidence Interval [CI]: 0.94 to 0.97, P = 1.19E-12). However, a separate analysis of CD and UC showed that this negative association appeared to exist only for T1DM and CD (IVW OR: 0.95, 95% CI: 0.91 to 0.99, P = 0.0063) and not for UC (IVW OR: 1.02, 95% CI: 0.98 to 1.05, P = 0.3315). In contrast, we found no difference in the prevalence of T1DM among patients with IBD, CD, and UC compared to the general population.
Conclusions: This study using MR has confirmed that individuals diagnosed with T1DM exhibit a decreased susceptibility to IBD in comparison to the general population，indicating that new therapeutic targets for IBD based on the pathogenesis of T1DM should be explored.
Pharmaceutical Reforms in Greece during the financial crisis
Authors: Constantopoulos Athanasios , Chantzaras Athanasios , Yfantopoulos John 
Published: July 2023

AbstractOBJECTIVES:The objective of this study was to study cost containment and cost reallocation and to discern how they burden households and the pharmaceutical industry.METHODS:For the period 2010-2020, we implemented content analysis on 377 statutes that concerned pharmaceutical expenditure. These measures were classified firstly with reference to their character as cost containing or rationing and, secondly, with respect to cost reallocation.RESULTS:The proportion of measures shifting healthcare costs to consumers was 31% and 48.5% to industry. Mean equivalized total consumption between 2008 and 2018 decreased by 31.5% while mean equivalized total health expenditure decreased by 20.5%. During the same period mean equivalized pharmaceutical expenditure increased by 25.56% and the proportion of households with positive expenditure increased by 31 %. Meanwhile pharmaceutical industry’s direct contribution to the total pharmaceutical expenditure increased from 1.5% in 2010 to 30.1% in 2020.CONCLUSIONS:Recent reforms (2010-2020) regarding pharmaceutical expenditure present a clear tendency to reallocate pharmaceutical cost to consumers and the pharmaceutical industry. This shifting of the cost from the public health sector to the private sector endanger the sustainability of the pharmaceutical sector, and the access of patients to quality pharmaceutical treatment.
The drospirenone only pill as a contraceptive option for breast feeding women. Safety aspects on new-born and users’ acceptability
Authors: Regidor Pedro Antonio , colli enrico , Jakimiuk Artur 
Published: July 2023

Abstract
Background
Progestin-only pills (POPs) and progestogen contraceptives have been used for contraception in breastfeeding women for years. When used by lactating women, POPs do not interfere with a woman's ability to breastfeed. Evidence from observational and randomized studies generally supports the notion that POPs do not have adverse effects on infant growth, health, or development during the first year postpartum.
Methods
This was a multicentre observational study conducted with a single visit and retrospective data review. The study involved 100 women who used a drospirenone-only pill (DRSP) for contraception during breastfeeding. The study aimed to analyse the impact on new-born development, assess the bleeding profile, and evaluate user satisfaction.
Results
The analysis of the new-borns showed that their growth parameters including length and weight were within the expected range of standard development. The mean birth weight was 3368 g (median 3360 g), with the lowest recorded weight being 860 g and the highest 5040 g. The median length of the new-borns was 55 cm, ranging from 35 cm to 65 cm. All new-borns demonstrated appropriate growth without any signs of retardation. No adverse effects were observed in the new-borns.
Regarding the satisfaction with the bleeding profile, the median satisfaction rating was 89.5, while the mean value was 82.8. Notably, women aged 35 years or older reported significantly higher satisfaction compared to younger women (≥35 years: mean=88.4, SD=16.5; <35 years: mean=80.3, SD=20.2) (p = 0.02).
More than half of all patients (N=61; 61.0%; 95% CI: 50.7 - 70.4%) expressed their willingness to continue using DRSP after breastfeeding, including 24 patients who had previously used combined oral contraceptives before their pregnancy.
Conclusion
The DRSP contraceptive pill demonstrated high safety for new-borns, with no clinical impact observed on their growth. Additionally, users expressed high satisfaction with the bleeding profile of the pill. Out of the users, sixty-one individuals decided to continue using this contraceptive method after breastfeeding, highlighting the effectiveness of the drospirenone-only pill as a valid option for contraception during and after breastfeeding.
Clinical trial registration number: DRKS00028438
Integrated analysis reveals CP is a potential biomarker and therapeutic target in glioma
Authors: Liu Linjiang , Xu Zhen , Wang Cuicui , Wu Cheng , Li Hongjian , Zhu Qianni , Gu Dayong , Zou Haijun , Li Weihua 
Published: July 2023

Abstract
Purpose:
Glioma is a challenging brain tumor with limited treatment options and poor prognosis. Ceruloplasmin (CP), a multicopper protein involved in oxidative stress and iron homeostasis, has been implicated in various cancers but its role in glioma remains unclear.
Methods:
In this study, we investigated the association between CP expression and various factors, including prognosis, tumor microenvironment (TME), immune infiltration, and immune checkpoint markers. We utilized single-cell sequencing data to assess the expression of CP in both glioma tissues and normal tissues. Furthermore, we conducted in vitro experimentation to evaluate the effects of CP knockdown on glioma cells.
Results:
Our findings demonstrated a significant correlation between high CP expression and unfavorable clinical characteristics, as well as poor overall survival in glioma patients. Enrichment analysis revealed associations between CP and immune-related pathways, suggesting its involvement in immune regulation. We observed increased immune infiltration in glioma cases exhibiting high CP expression. Additionally, CP expression showed positive correlation with immune checkpoint genes, indicating its potential as an immunotherapy target. Single-cell analysis confirmed the expression of CP in both tumor and immune cells, further supporting its role as a biomarker. Moreover, our in vitro knockdown experiments demonstrated that inhibiting CP suppressed glioma cell proliferation.
Conclusion:
In summary, our findings suggest that CP is associated with glioma progression, immune regulation, and holds potential therapeutic implications.