bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Poorly Differentiated Esophageal Neuroendocrine Carcinoma With Brain Metastasis
Authors: Swied Muhammed Yaman , Turk Yahia Al , Jegadeesan Ramprasad 
Published: September 2023

ABSTRACT
Esophageal neuroendocrine carcinomas (NECs) are a rare type of esophageal neoplasm that can initially present with vague signs and symptoms. Gastrointestinal manifestations, such as dysphagia and abdominal discomfort, are the most common symptoms of neuroendocrine neoplasms. Although there is a potential for distant metastases because of esophageal NEC, few cases of brain metastasis have been reported. We report a rare case of an esophageal NEC metastasizing to the brain region.
Lupus Pancreatitis Masquerading as Pancreatic Cancer: A Rare Clinical Presentation
Authors: Lanke Gandhi , Songtanin Busara , Das Kanak 
Published: September 2023

ABSTRACT
Systemic lupus erythematosus (SLE) is an autoimmune multisystemic inflammatory disease. SLE-associated pancreatitis is uncommon, and pancreatic cancer in SLE is very rare. Imaging findings in SLE with pancreatitis can mimic malignancy. Endoscopic ultrasound with fine-needle aspiration/biopsy can guide in the accurate diagnosis and management of SLE-associated pancreatitis.
A Potential New Use for Tocilizumab: Refractory Checkpoint Inhibitor Hepatitis
Authors: Lyles Laine , Farmer Reagan , Abougergi Marwan 
Published: September 2023

ABSTRACT
Immune checkpoint inhibitors are becoming more commonly used for many forms of malignancy. With this class of medications being more heavily used, there has been an associated rise in medication-induced autoimmune hepatitis. This case involves a 35-year-old woman being treated with nivolumab/ipilimumab for renal cell carcinoma who developed a steroid-refractory autoimmune hepatitis.
Nonresolving Axillary Lymphadenopathy: An Unexpected Case of Metastatic Jejunal Adenocarcinoma in a Small-Bowel Transplant Recipient Masquerading as Posttransplant Lymphoproliferative Disorder
Authors: Hemy Alexander , Fetz Andrew , Kim Hyun Jae , Owen Daniel , Jayakumar Saumya 
Published: September 2023

ABSTRACT
Intestinal transplant is an uncommon treatment of intestinal failure that has provided many patients with reduced morbidity and mortality. However, there are associated risks, including an increased risk of cancer, such as posttransplant lymphoproliferative disorder and solid-organ malignancy. Here, we report a unique case of primary jejunal adenocarcinoma presenting initially only with axillary lymphadenopathy in a patient with recurrent posttransplant lymphoproliferative disorder after multiple solid-organ transplants, including small intestine and 2 renal transplants.
Post-transcriptional gene silencing in a dynamic RNP world
Authors: Larivera Simone , Neumeier Julia , Meister Gunter 
Published: September 2023

Abstract
MicroRNA (miRNA)-guided gene silencing is a key regulatory process in various organisms and linked to many human diseases. MiRNAs are processed from precursor molecules and associate with Argonaute proteins to repress the expression of complementary target mRNAs. Excellent work by numerous labs has contributed to a detailed understanding of the mechanisms of miRNA function. However, miRNA effects have mostly been analyzed and viewed as isolated events and their natural environment as part of complex RNA-protein particles (RNPs) is often neglected. RNA binding proteins (RBPs) regulate key enzymes of the miRNA processing machinery and furthermore RBPs or readers of RNA modifications may modulate miRNA activity on mRNAs. Such proteins may function similarly to miRNAs and add their own contributions to the overall expression level of a particular gene. Therefore, post-transcriptional gene regulation might be more the sum of individual regulatory events and should be viewed as part of a dynamic and complex RNP world.
An Experimental Study on Excess Pore-Water Pressure Generation of a Poorly Graded Sand Using Combined RCTS Device
Authors: Xu Zhongze , Li Shiyuan , Wang Yaning , Zhang Benchen , Stokoe Kenneth H. 
Published: September 2023

Abstract
The combined dynamic torsional resonant column and cyclic torsional shear (RCTS) device is employed to study the generation of excess pore-water pressure, especially the threshold shear strain of excess pore-water pressure, γtPP, in an uncemented poorly graded granular soil. Reconstituted specimens of uncemented sand were constructed under water and then tested in the RCTS device using a newly designed base pedestal, with which pore-water pressure is measured at four points systematically located at 0.75 times the radius of the base pedestal. Specimens were tested under different mean effective confining pressures, and all specimens had B-values above 0.95 at the start of testing. During testing, the excess pore-water pressure was measured continuously during 30 cycles of loading at multiple increasing loading levels. The three major factors influencing γtPP that were investigated are as follows: (1) mean effective confining pressure, (2) relative density, and (3) loading frequency. The results are presented in terms of the following: (1) excess pore-water pressure ratio versus shear strain, and (2) threshold shear strain versus number of loading cycles. Other related behaviors such as softening during cycling and post-cyclic moduli changes are also discussed.
Applying the Integrated Digital Image Correlation Method to Detect Stress Measurements in Precision Drilling
Authors: Shih Ming-Hsiang , Tung Shih-Heng , Sung Wen-Pei 
Published: September 2023

Abstract
Drilling is a precision machining method, and stress measurement in situ can be used to evaluate its machining efficiency. The most used technique for measuring the stress state of the tested object is the drilling method or the blind hole method. By measuring the relative deformation before and after drilling using deformation measurement techniques, the stress tensor before drilling can be derived. The traditional digital image correlation (DIC) method has a large stress recognition error and faces problems such as rigid body displacement and image scaling that can affect accuracy. This study proposes a new experimental method that incorporates rigid body displacement parameters into the Nelson–integrated DIC identification parameters, with the aim of perfecting both rigid body displacement and stress recognition accuracy. The results show that the images identified by this method exhibit a high degree of agreement, confirming the convergence and applicability of the displacement field in the wired limited-scale specimens. The compensation method for false strain proposed in this study has been experimentally verified to be highly dependable. The results of the current stress measurement are in good agreement with the predrilling stress measured by DIC, with a main stress measurement error of only 1.57 % of the reference stress. This method can improve the accuracy of image measurement methods and become a low-cost, high-precision, and highly mobile current stress measurement technology.
Tectorigenin suppresses the viability of gastric cancer cells in vivo and in vitro
Authors: Song Wenchong , Lv Weiwei , Bi Ning , Wang Guanglin 
Published: September 2023

Gastric cancer is currently the 4th most common malignant tumor with a poor prognosis in 2022. New and effective drugs are needed to combat this disease to treat advanced gastric cancer. Tectorigenin (Tec) has a series of pharmacological activities, such as anti-inflammatory and anticancer. However, the effect of Tec on the progression of gastric cancer is unclear. In this study, we investigated the role of Tec in regulating cell viability, cell cycle, and tumor growth of gastric cancer. To detect the role of Tec in the progression of gastric cancer in vitro and in mice, we performed several in vitro assays such as MTT, colony formation, wound closure, transwell, Immunoblot assays, and in vivo tumor growth assays. Our data confirmed that Tec restrained the viability of gastric cancer cells at concentrations of 100, 200, and 300 μM. It also denied the motility of gastric cancer cells. Tec treatment also induced the cell cycle arrest of gastric cancer cells. Mechanically, Tec could suppress the activation of the PI3K/Akt pathway and stop gastric cancer progression. We, therefore, thought Tec could serve as a drug for treating gastric cancer.
Immune-Cell-Mediated Cancer Treatment: Advantages, Drawbacks And Future Direction
Authors: Lwin Ohn Mar , Baig Atif Amin , Jamaludin Nurul Akmal , Aung Thin Thin , Norman Haziq Hazman , Oo Aung Myo 
Published: September 2023

Cancer ranks as the most lethal and prevalent non-communicable disease in clinical settings. Therapeutic options for cancer comprise chemotherapy, radiotherapy, surgery, and combined treatment. Cancer remission and relapse cases are widespread despite having various advanced medications and sophisticated dissection techniques. A new approach involving immune-cell-mediated cancer therapy has been adopted extensively for cancer treatments by utilizing immune cells. Immunotherapy has gained much attention to prevent and treat various types of cancer. Immunotherapy treatments operate in multiple contexts. Several immunotherapy therapeutic interventions assist the immune function in halting or reducing the advancement of cancer cells. Many also facilitate the immune cells in destroying cancerous cells or safeguarding against cancer from disseminating to certain other regions of the human body. Among other methods, genetic manipulation of immune cells offers hope for innovative anticancer treatment. T lymphocytes and natural killer cells have become the most extensively documented immune cells for immunotherapy. Chimeric antigen receptor T-cell therapy exhibits the most promising blood cancer treatment. However, adoptive NK cell transfer therapy displays potential anticancer treatment options, although more research is needed to be carried out. In addition, cytokine-induced immunomodulation is also plausible for cancer immunotherapy. This review will highlight the most comprehensive information, observations, and consequences associated with different cancer immunotherapy initiatives.
Assessment of bacterial diversity in the chicken litter: A potent risk to environmental health
Authors: Kumar Sunil , Anwer Razique , Mehra Neera , Devi Tamanna , Yadav Mukesh , Sehrawat Nirmala , Sharma Anil Kumar 
Published: September 2023

Using chicken litter as an organic fertilizer on land is the most common, cheapest and environmentally safest way to manage the latter generated swiftly from the poultry industry. Raw chicken litter has been applied to field soils where various vegetables are cropped to increase yield or productivity. However, the chicken litter frequently come in contact with different environments, such as water, soil, microbes and vegetation. When chickens defecate, their litters, in a few countries, are particularly reused for the next flock, potentially causing cross-contamination. Due to various contact points in the environment, a high probability of bacterial transmission is predicted, which could lead to infection spread in animals and humans. Consumption of contaminated water, food, and meat could lead to the transmission of deadly infections. Microbes in the chicken litter also affect the grazing animals while feeding on fields duly applied with chicken litter as manure. The maximum permissible limits (MPLs) in the chicken litter for land application should not exceed 106-108 CFU/g for Coliform bacteria. Antibiotics are regularly mixed in the diet or drinking water of chicken grown in marketable poultry farms for treating bacterial diseases. Rampant usage of antimicrobials also results in resistant bacteria's survival in animal excreta. Herein, we surveyed the literature to identify the major bacterial genus harboured in the fields applied with chicken manure to increase soil fertility. Our detailed survey identified different bacterial pathogens from chicken litter samples from different investigations. Most studies showed the prevalence of Campylobacter, Salmonella, Enterococcus, E. coli, Bacillus, Comamonas, Proteus and Citrobacter, including many other bacterial species in the chicken litter samples. This article suggested that chicken litter does not meet the standard parameters for direct application as organic fertilizer in the fields. Before being applied to the ground, chicken litter should be treated to lessen the danger of polluting crops or water supplies by reducing the prevalence of harmful bacteria carrying antibiotic-resistance genes.
Length-Weight Relationship and Condition Factor of Oreochromis niloticus (Linnaeus, 1758) in Selected Tropical Reservoirs of Ekiti State, Southwest Nigeria
Authors: P. T. Olagbemide , O. D. Owolabi 
Published: September 2023

In Ekiti State, southwest Nigeria, Oreochromis niloticus is significant to live. This investigation was conducted to improve its sustainable management and access the length-weight relationship and condition factor of O. niloticus across important reservoirs in Ekiti State from November 2017 to October 2019. Collected specimens were weighed to the nearest gram, while the entire lengths were measured to the closest centimetre. Log-transformed regression was used to determine the fish's growth pattern in the reservoirs. The gradient comparison was done using the T-test. The length and weight of the species in the reservoirs showed a significant association. All length-weight relationships had r2 values greater than 0.8150 and were significant at P < 0.05. In the length-weight relationship of O. niloticus, the values of the exponent b in Egbe, Ero, and Ureje reservoirs varied from 2.45 to 2.87, 3.02 to 3.20, and 2.45 to 2.82, respectively. The results of regression coefficient b obtained showed that in the combined season, male, female and combined sexes from the Ero reservoir had isometric growth patterns with growth exponent b values of 3.18, 3.20 and 3.19 respectively that were not statistically different from 3. These results contradicted the negative allometric growth pattern in the Egbe and Ureje reservoirs. The condition factor during the dry season ranged from 1.93-2.05, 2.05-2.11, and 1.93-2.03 for fish in Egbe, Ero, and Ureje reservoirs, respectively while in the rainy season, it ranged from 2.00-2.02; 2.08-2.09 and 1.96-2.01 respectively. The fish species studied in the reservoirs lived above- average life and thus indicate that the prevailing ecological conditions in the reservoirs were not beyond the forbearance range for the fish species since their condition factors were within the range considered adequate for freshwater fishes in tropical waters.
Formula covering black holes and the industrial sample negative germ
Authors: Alvandi Rezvan 
Published: September 2023

The main purpose of this study is to discuss the ways of neutralizing the resultant forces on the spacecraft in the black hole so that they can be equal to zero.
Based on Einstein's relativity theory*, the intensity of the gravity force reduces the speed of the mass. But we all know that this formula is not true about black holes, since black holes' high gravity absorbs everything, including light. However, the issue of space craft’s passing through black holes with the speed of light is still debatable, although the required formula has not been discovered yet. In this paper, it has been attempted to discuss the ways of discovering the formula for calculating the forces imposed on the spacecraft and ways of neutralizing these forces, so that the spacecraft can successfully pass through the black holes. First, we tried to use the singularity to find the next location of the spacecraft's appearance. Then, we discussed how to produce the laboratory sample of negative germ to neutralize the resultant forces on the spacecraft.
Pengaruh Model Pembelajaran Discovery Learning Berbasis Literasi Sains terhadap Peningkatan Kemampuan Berpikir Ilmiah Siswa
Authors: Ahfiani Wahdatul Fitria , Arif Syaiful 
Published: September 2023

Pada era sekarang peserta didik dituntut mampu berpikir tingkat tinggi. Salah satu keahlian dalam berpikir tingkat tinggi yaitu memiliki kemampuan berpikir ilmiah. Dengan memiliki kemampuan berpikir ilmiah peserta didik dapat berpikir dengan lebih teliti dan meluas. Selain itu dengan memiliki kemampuan berpikir ilmiah maka peserta didik dapat mengembangkan kemampuan berargumentasi yang sesuai dengan bukti dan pengalaman penyelidikan sains. Penelitian ini dilatarbelakangi oleh kemampuan berpikir ilmiah peseta didik yang masih kurang yaitu dengan nilai 58. Dengan adanya penelitian ini maka dapat meningkatkan kemampuan berpikir ilmiah peserta didik sehingga dapat memenuhi tuntutan era abad 21. Metode yang digunakan yaitu penelitian kuantitatif dengan teknik penelitian quasi eksperimen. Bentuk quasi eksperimen yang digunakan dalam penelitian ini adalah the matching only pretest postest design yang terdiri atas kelompok kontrol dan kelompok eksperimen. Data diperoleh melalui lembar observasi dan tes yang telah divalidasi oleh ahli, serta soal tes berbentuk uraian. Data yang diperoleh dianalisis menggunakan uji t. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran discovery learning berbasis literasi sains terhadap peningkatan kemampuan berpikir ilmiah. Berdasarkan hasil analisis data diketahui bahwa terdapat pengaruh model pembelajaran discovery learning berbasis literasi sains terhadap kemampuan berpikir ilmiah peserta didik pada mata pelajaran IPA diketahui berdasarkan hasil uji analisis data uji t two tailed yang diperoleh hasil P-value sebesar 0,000 dan kurang dari alfa yang bernilai 0,05.
Relationship Between Obesity Awareness and Nutrition Attitude: A Sectional Study Among Secondary School Students
Authors: Ayran Gulsun , Karaca Ozlem 
Published: September 2023

This study was aimed to identify the relationship between obesity awareness and nutrition attitudes among secondary school students.
Methods. This descriptive research was conducted between April and June 2022 and involved 625 secondary school students of a province in Eastern Turkey. The data were collected using a question form consisting of a questionnaire, the Obesity Awareness Scale (OAS), and the Attitude Scale for Healthy Nutrition (ASHN). One-way ANOVA, independent sample t-test, Pearson correlation, and regression analysis were used to interpret the data.
Results. There was a balanced distribution of descriptive characteristics among the study population. In this study, age and grade level were effective on the ASHN and OAS. Additionally, there were significant differences in the OAS score only by gender; however, the ASHN value significantly depended on weight assessment status, regular eating, and body mass index variables. Although there was a considerable deviation observed within the assessed sample regarding unhealthy behaviors, average time spent per day on the computer, phone, or television was approximately one hour. Although the study population had a positive attitude towards healthy eating and a high awareness of obesity, it was seen that students consumed junk food twice per day and fast food once a week on average. A regression analysis revealed a significant negative impact of time spent per day on the phone and junk food consumption on the ASHN; however, regular eating and OAS had positive effects.
Conclusions. As students’ attitudes towards healthy nutrition increased, their levels of obesity awareness increased as well. Unhealthy lifestyle factors such as phone usage and junk food intake negatively affected healthy eating attitudes.
Incorporating Community Partner Perspectives on eHealth Technology Data Sharing Practices for the California Early Psychosis Intervention Network: Qualitative Focus Group Study With a User-Centered Design Approach
Authors: Tully Laura M , Nye Kathleen E , Ereshefsky Sabrina , Tryon Valerie L , Hakusui Christopher Komei , Savill Mark , Niendam Tara A 
Published: September 2023

BackgroundIncreased use of eHealth technology and user data to drive early identification and intervention algorithms in early psychosis (EP) necessitates the implementation of ethical data use practices to increase user acceptability and trust.ObjectiveFirst, the study explored EP community partner perspectives on data sharing best practices, including beliefs, attitudes, and preferences for ethical data sharing and how best to present end-user license agreements (EULAs). Second, we present a test case of adopting a user-centered design approach to develop a EULA protocol consistent with community partner perspectives and priorities.MethodsWe conducted an exploratory, qualitative, and focus group–based study exploring mental health data sharing and privacy preferences among individuals involved in delivering or receiving EP care within the California Early Psychosis Intervention Network. Key themes were identified through a content analysis of focus group transcripts. Additionally, we conducted workshops using a user-centered design approach to develop a EULA that addresses participant priorities.ResultsIn total, 24 participants took part in the study (14 EP providers, 6 clients, and 4 family members). Participants reported being receptive to data sharing despite being acutely aware of widespread third-party sharing across digital domains, the risk of breaches, and motives hidden in the legal language of EULAs. Consequently, they reported feeling a loss of control and a lack of protection over their data. Participants indicated these concerns could be mitigated through user-level control for data sharing with third parties and an understandable, transparent EULA, including multiple presentation modalities, text at no more than an eighth-grade reading level, and a clear definition of key terms. These findings were successfully integrated into the development of a EULA and data opt-in process that resulted in 88.1% (421/478) of clients who reviewed the video agreeing to share data.ConclusionsMany of the factors considered pertinent to informing data sharing practices in a mental health setting are consistent among clients, family members, and providers delivering or receiving EP care. These community partners’ priorities can be successfully incorporated into developing EULA practices that can lead to high voluntary data sharing rates.
Serum Zonulin and Growth Differentiation Factor-15 levels support link between Coronary Artery Disease: The Liver-Heart Axis
Authors: Jasim Aliaa Ahmed , Ali Hanaa Addai , Kadhim Maha Mohammed , Al-haidari Ahmed Qasim , Al-Tu’ma Fadhil Jawad 
Published: September 2023

Objectives: This study aimed to evaluate associations between serum zonulin and GSF-15 levels in coronary arteries with NAFLD patients and to study their correlations with different parameters.
Methods: In this case-control study, 90 subjects were collected, consisting of 45 coronary artery disease with non-alcoholic fatty liver (Grade one) patients and 45 controls, Clinical demographic information, including family history of coronary disease, lifestyle factors including hypertension and diabetes, and certain blood parameters data (lipid profile, liver functions test).
Results: The patients' mean age was 55.64±8.462 years. Among all participants, 64(71.1%) were male and 26(28.9%) female. Zonulin, GDF-15, triglycerides, ALT, AST, ALP, and LDL levels were significantly higher in the patients (p≤0.001, p≤0.001, p=0.022, p≤0.001, p=0.035, p≤0.001, p≤0.001, respectively). In comparison to the controls, HDL and total cholesterol were considerably higher (p≤0.001 and p≤0.001).
Conclusion: Patients who suffer from non-alcoholic fatty liver disease and coronary arteries had higher levels of zonulin and GDF-15.