bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribución de la patología oncológica en pacientes adolescentes y adultos jóvenes en la provincia de Córdoba, Argentina
Authors: Biga Allais Maria Paulina , Dutari Pilar , Llanos Romina B. , Ferreira Gimena , Nicolas Graciela , Musso Verónica 
Published: September 2023

Introducción: El cáncer en el adolescente y adulto jóven (AYA) tiene una biología tumoral más agresiva y suele diagnosticarse con mayor retraso, lo que podría incidir negativamente en la sobrevida de este grupo poblacional. Objetivo: Determinar la distribución de cáncer en pacientes adolescentes y adultos jóvenes en la provincia de Córdoba. Método: Estudio retrospectivo y observacional. Se incluyeron pacientes desde enero 2012 a diciembre 2017, entre 15 a 39 años; los datos fueron obtenidos del registro provincial de tumores de Córdoba. Resultados: De 4742 pacientes, 65% eran sexo femenino; edad media al diagnóstico 30.6 años. Los cánceres más frecuentes fueron: cuello uterino 22.14%, mama 13.15%, testículo 9.36%, colorrectal 8.26%, tiroides 5.44%, linfoma no Hodgkin 4.85%, linfoma Hodgkin 4.72%, sistema nervioso central 4.4%, leucemias 3.9%, melanomas 1.66% y sarcomas 2.4%. El linfoma Hodgkin fue la neoplasia más frecuente entre 15 y 19 años, cáncer de cuello uterino entre 20 y 29 años y cáncer de mama entre 30 y 39 años. Conclusión: En esta población específica AYA, se observó una alta incidencia de cáncer de cérvix, mama y colorrectal. Sería necesario generar estrategias de detección temprana para estos tumores en pacientes AYA, que sean independientes de las recomendaciones de screening en la edad adulta, ya que podrían ser curados en estadios tempranos.
Pengaruh Sertifikat Bank Indonesia Syariah (SBIS), Inflasi, dan Nilai Tukar Rupiah Terhadap Harga Saham Perusahaan Jakarta Islamic Indeks
Authors: Hafizh Naufal , Al-Idrus Salim , Suprayitno Eko 
Published: September 2023

Di Indonesia tingkat suku bunga Bank sentral diproxykan pada tingkat suku bunga Sertifikat Bank Indonesia Syariah (SBIS). Sehingga investor akan menjual sahamnya dan kemudian akan menyimpan dananya di bank. Penjualan saham yang serentak akan berdampak pada penurunan harga secara signifikan. Peneliti memilih Jakarta Islamic Index (JII) karena JII merupakan saham yang mewakili pergerakan 30 saham syariah (Bidang usahanya sesuai dengan hukum Islam) yang memiliki kapitalisasi pasar terbesar dengan transaksi terlikuid. Penelitian ini bertujuan untuk meganalisis pengaruh SBIS terhadap harga saham perusahaan JII 2012-2017, pengaruh inflasi terhadap harga saham perusahaan di JII 2012-2017 dan pengaruh nilai tukar tambah terhadap harga saham perusahaan JII 2012-2017. Penelitian ini menggunakan desain penelitian metode penelitian kuantitatif. Populasi dari penelitian ini adalah seluruh perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia sampai dengan tahun 2017, yaitu sebanyak 30 perusahaan. Dalam proses pengambilan sampel dipergunakan metode purposive sampling dengan beberapa kriteria. Variabel penelitian terdiri dari harga saham, nilai tukar, inflasi dan suka bunga (BI rate). Data yang dikumpulkan menggunakan dokumentasi yaitu dengan mengolah data-data tertulis yang berhubungan dengan masalah penelitian baik dari sumber dokumen, buku-buku, koran, majalah, internet dan lain-lain. Hasil penelitian menjelaskan bahwa hasil analisis data panel menunjukkan SBISm Inflasi dan Kurs secara simultan berpengaruh signifikan terhadap Harga Saham, hasil analisis data panel secara parsial, diketahui pengaruhnya yaitu variabel kurs berpengaruh signifikan terhadap Harga Saham perusahaan, dan Variabel Inflasi tidak berpengaruh signifikan terhadap Harga Saham perusahaan.
Propuesta metodológica para identificar tipos de conocimientos utilizados por docentes de Matemática
Authors: Rodríguez Mabel , Jader Daniel , Umbricht Guillermo Federico 
Published: September 2023

En este artículo se presenta una propuesta metodológica que permite describir el conocimiento especializado del profesor de matemática que puso en juego para planificar la enseñanza bajo requerimientos didáctico-matemáticos dados. Se enmarca teóricamente el trabajo realizado, se presenta la propuesta metodológica y se incluye parte del análisis de un caso particular, a modo de ejemplo. Se encuentran, para ese caso, decisiones que toma un docente, y acciones que realiza, para responder al requerimiento de favorecer el desarrollo, en los estudiantes, de herramientas de trabajo intelectual. La identificación de las decisiones y acciones permite reconocer tipos de conocimientos y articularlos con cuestiones vinculadas a las creencias, que en este trabajo se consideraron parte de la epistemología personal del profesor. Se plantean, como cierre, algunas líneas de trabajo futuras que permitirán profundizar el estudio.
El diseño de buenos problemas para la clase de Matemática
Authors: Pochulu Marcel 
Published: September 2023

Presentamos y fundamentamos algunos criterios que deberían tenerse en cuenta en el diseño de buenos problemas para la clase de Matemática, como así también, para la gestión de la misma por parte del profesor. Estos criterios surgen del análisis de documentos oficiales para la enseñanza de la Matemática y de las investigaciones que se realizaron en torno al diseño de tareas para la clase. Los criterios propuestos implican iniciar un proceso de cuestionamiento respecto del saber matemático y el saber matemático escolar, que se sintetiza al preguntarnos, ¿por qué debería enseñar este con- tenido?, ¿existen otras maneras de enseñar en este contexto y para esta carrera de ingeniería?, ¿qué problemas son más apropiados para esta carrera? y evitar la reproducción de modelos que, seguramen- te, estuvieron presentes en nuestra formación previa. Finalmente, ofrecemos 5 ejemplos de problemas que cumplen con estos criterios, las intencionalidades didácticas y el modo en que el profesor podría gestionar la clase.
Evidence for the utility of cfDNA plasma concentrations to predict disease severity in COVID-19: a retrospective pilot study
Authors: Hoeter Katharina , Neuberger Elmo , Fischer Susanne , Herbst Manuel , Juškevičiūtė Ema , Enders Kira , Rossmann Heidi , Sprinzl Martin F. , Simon Perikles , Bodenstein Marc , Schaefer Michael 
Published: September 2023

Background
COVID-19 is a worldwide pandemic caused by the highly infective SARS-CoV-2. There is a need for biomarkers not only for overall prognosis but also for predicting the response to treatments and thus for improvements in the clinical management of patients with COVID-19. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker in the assessment of various pathological conditions. The aim of this retrospective and observational pilot study was to investigate the range of cfDNA plasma concentrations in hospitalized COVID-19 patients during the first wave of SARS-CoV-2 infection, to relate them to established inflammatory parameters as a correlative biomarker for disease severity, and to compare them with plasma levels in a healthy control group.

Methods
Lithium-Heparin plasma samples were obtained from COVID-19 patients (n = 21) during hospitalization in the University Medical Centre of Mainz, Germany between March and June 2020, and the cfDNA concentrations were determined by quantitative PCR yielding amplicons of long interspersed nuclear elements (LINE-1). The cfDNA levels were compared with those of an uninfected control group (n = 19).

Results
Plasma cfDNA levels in COVID-19 patients ranged from 247.5 to 6,346.25 ng/ml and the mean concentration was 1,831 ± 1,388 ng/ml (± standard deviation), which was significantly different from the levels of the uninfected control group (p < 0.001). Regarding clinical complications, the highest correlation was found between cfDNA levels and the myositis (p = 0.049). In addition, cfDNA levels correlated with the “WHO clinical progression scale”. D-Dimer and C-reactive protein (CRP) were the clinical laboratory parameters with the highest correlations with cfDNA levels.

Conclusion
The results of this observational pilot study show a wide range in cfDNA plasma concentrations in patients with COVID-19 during the first wave of infection and confirm that cfDNA plasma concentrations serve as a predictive biomarker of disease severity in COVID-19.
The Reality of Digital Transformation at Jordanian Universities from the Perspective of Administrators
Authors: Alsayed Kholoud Waleed , Alassaf Hamzeh Abdelfattah 
Published: September 2023

The study aimed to identify the Reality of Digital Transformation at Jordanian Universities from Administrators Perspectives. To meet the study objectives, the stratified random method was chosen due to its suitability for the study. The primary tool was the questionnaire, which distributed 410 administrators, 255 of them responded.
The study used the descriptive survey method, where the four-axis study tool was developed as following: digital culture, institutional support, infrastructure, insight and vision.
The study’s results indicated that the administrators’ estimations for the digital transformation at Jordanian Universities had intermediate rating; moreover, the institutional support ranked first.
Furthermore, The results indicated that there are statistically significant differences in the administrators’ estimations for the digital transformation at Jordanian Universities according to the experience’s variable, for the benefit of the administrators whom have experience (less than 5 years), administrative department variable, administrative staff members who are working in (the presidency), university’s variable (governmental, private), and for the benefit of private universities.
As a result, the study recommended focusing and paying attention to the institutional support for digital transformation at universities through continuous development and innovation.
Performance of the Dental Surgeon in the Multiprofessional Team: A Systematic Review
Authors: Duarte Ana Vitória Machado , Pessoa Camilla Lucena , Oliveira Giovana Gisele Costa , Carvalho Hortência Magge Almada de , Alves Iara Pereira da Cruz , Lopes Karitha Freire dos Santos , Alves Wellington Henrique Reis Santos , Santos Stanley Keynes Duarte dos 
Published: September 2023

Background: Dentistry is the health area responsible for the care of the stomatognathic system, with preventive, curative and rehabilitative actions, aiming at the promotion and protection of the patient's health in its entirety. In this regard, multidisciplinary action is essential for implementing health policies at all levels of care. This article aims to carry out a systematic literature review to analyze the relevant aspects of the role of dentistry professionals in multidisciplinary teams.
Methods: Review of the qualitative literature in the PubMed, Scielo and LILACS databases, using the health descriptors "Dentistry" and "Multidisciplinary Team" and selected publications between 2018 and 2022 with thematic relevance.
Results and Discussion: After the research, considering the inclusion and exclusion criteria and thematic relevance, 11 articles were selected. The performance of the dental surgeon in a multidisciplinary team is essential in the care of patients affected by neoplastic disease, heart disease, hospitalized patients and those in Intensive Care Units (ICU). Academic and professional training in multiprofessional residency programs is also a point of interest in achieving a multidisciplinary approach to health care.
Conclusion: After the analysis, it was verified that the analyzed literature exposes relevant aspects of the performance of the dentistry professional in a multidisciplinary team, in particular, in the follow-up, evaluation and dental treatment aimed at the benefit of the patient and for the integration with the different specialties of the team of health.
Buprenorphine Dose and Time to Discontinuation Among Patients With Opioid Use Disorder in the Era of Fentanyl
Authors: Chambers Laura C. , Hallowell Benjamin D. , Zullo Andrew R. , Paiva Taylor J. , Berk Justin , Gaither Rachel , Hampson Aidan J. , Beaudoin Francesca L. , Wightman Rachel S. 
Published: September 2023

ImportanceBuprenorphine treatment for opioid use disorder (OUD) has more than doubled since 2009. However, current US Food and Drug Administration buprenorphine dosing guidelines are based on studies among people using heroin, prior to the emergence of fentanyl in the illicit drug supply.ObjectiveTo estimate the association between buprenorphine dose and time to treatment discontinuation during a period of widespread fentanyl availability.Design, Setting, and ParticipantsThis retrospective cohort study used statewide Rhode Island Prescription Drug Monitoring Program data. Participants were Rhode Island residents initiating buprenorphine treatment for OUD between October 1, 2016, and September 30, 2020. Data analysis was performed from December 9, 2022, to August 10, 2023.ExposureDaily dose of buprenorphine (16 mg and 24 mg) defined starting on the day of initiation based on total quantity and days’ supply dispensed. Patients were censored on any dose change.Main Outcomes and MeasuresBuprenorphine treatment discontinuation in the 180 days following initiation, defined as a gap in treatment of more than 27 days based on prescription fill dates and days’ supply. Kaplan-Meier and Cox regression survival analyses were conducted to estimate the association between buprenorphine dose and time to treatment discontinuation, controlling for potential informative censoring and measured potential confounders.ResultsAmong 6499 patients initiating buprenorphine treatment for OUD, most were aged 25 to 44 years (57%; n = 3682), were male (61%; n = 3950), and had private (47%; n = 3025) or Medicaid (33%; n = 2153) insurance. More than half of patients were prescribed a daily dose of interest at initiation (16 mg: 50%; n = 3264; 24 mg: 10%; n = 668). In Kaplan-Meier analyses, 58% of patients discontinued buprenorphine treatment within 180 days (16 mg: 59% vs 24 mg: 53%; log-rank test P = .005). In Cox regression analyses, patients prescribed a dose of 16 mg had a greater risk of treatment discontinuation than those prescribed 24 mg (adjusted hazard ratio, 1.20; 95% CI, 1.06-1.37).Conclusions and RelevanceIn this cohort study of patients initiating buprenorphine treatment from 2016 to 2020, patients prescribed a 24 mg dose of buprenorphine remained in treatment longer than those prescribed 16 mg. The value of higher buprenorphine doses than currently recommended needs to be considered for improving retention in treatment.
Outcomes in Patients With Poststroke Seizures
Authors: Misra Shubham , Kasner Scott E. , Dawson Jesse , Tanaka Tomotaka , Zhao Yize , Zaveri Hitten P. , Eldem Ece , Vazquez Juan , Silva Lucas Scárdua , Mohidat Saba , Hickman L. Brian , Khan Erum I. , Funaro Melissa C. , Nicolo John-Paul , Mazumder Rajarshi , Yasuda Clarissa Lin , Sunnerhagen Katharina S. , Ihara Masafumi , Ross Joseph S. , Liebeskind David S. , Kwan Patrick , Quinn Terence J. , Engel Jerome , Mishra Nishant K. 
Published: September 2023

ImportancePublished data about the impact of poststroke seizures (PSSs) on the outcomes of patients with stroke are inconsistent and have not been systematically evaluated, to the authors’ knowledge.ObjectiveTo investigate outcomes in people with PSS compared with people without PSS.Data SourcesMEDLINE, Embase, PsycInfo, Cochrane, LILACS, LIPECS, and Web of Science, with years searched from 1951 to January 30, 2023.Study SelectionObservational studies that reported PSS outcomes.Data Extraction and SynthesisThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used for abstracting data, and the Joanna Briggs Institute tool was used for risk-of-bias assessment. Data were reported as odds ratio (OR) and standardized mean difference (SMD) with a 95% CI using a random-effects meta-analysis. Publication bias was assessed using funnel plots and the Egger test. Outlier and meta-regression analyses were performed to explore the source of heterogeneity. Data were analyzed from November 2022 to January 2023.Main Outcomes and MeasuresMeasured outcomes were mortality, poor functional outcome (modified Rankin scale [mRS] score 3-6), disability (mean mRS score), recurrent stroke, and dementia at patient follow-up.ResultsThe search yielded 71 eligible articles, including 20 110 patients with PSS and 1 166 085 patients without PSS. Of the participants with PSS, 1967 (9.8%) had early seizures, and 10 605 (52.7%) had late seizures. The risk of bias was high in 5 studies (7.0%), moderate in 35 (49.3%), and low in 31 (43.7%). PSSs were associated with mortality risk (OR, 2.1; 95% CI, 1.8-2.4), poor functional outcome (OR, 2.2; 95% CI, 1.8-2.8), greater disability (SMD, 0.6; 95% CI, 0.4-0.7), and increased dementia risk (OR, 3.1; 95% CI, 1.3-7.7) compared with patients without PSS. In subgroup analyses, early seizures but not late seizures were associated with mortality (OR, 2.4; 95% CI, 1.9-2.9 vs OR, 1.2; 95% CI, 0.8-2.0) and both ischemic and hemorrhagic stroke subtypes were associated with mortality (OR, 2.2; 95% CI, 1.8-2.7 vs OR, 1.4; 95% CI, 1.0-1.8). In addition, early and late seizures (OR, 2.4; 95% CI, 1.6-3.4 vs OR, 2.7; 95% CI, 1.8-4.1) and stroke subtypes were associated with poor outcomes (OR, 2.6; 95% CI, 1.9-3.7 vs OR, 1.9; 95% CI, 1.0-3.6).Conclusions and RelevanceResults of this systematic review and meta-analysis suggest that PSSs were associated with significantly increased mortality and severe disability in patients with history of stroke. Unraveling these associations is a high clinical and research priority. Trials of interventions to prevent seizures may be warranted.
Screen Time and Developmental Performance Among Children at 1-3 Years of Age in the Japan Environment and Children’s Study
Authors: Yamamoto Midori , Mezawa Hidetoshi , Sakurai Kenichi , Mori Chisato ,   Japan Environment and Children’s Study Group, Kamijima Michihiro , Yamazaki Shin , Ohya Yukihiro , Kishi Reiko , Yaegashi Nobuo , Hashimoto Koichi , Mori Chisato , Ito Shuichi , Yamagata Zentaro , Inadera Hidekuni , Nakayama Takeo , Sobue Tomotaka , Shima Masayuki , Kageyama Seiji , Suganuma Narufumi , Ohga Shoichi , Katoh Takahiko 
Published: September 2023

ImportanceIt is unclear whether increased television (TV) and DVD viewing in early childhood from age 1 year decreases development or whether poor development increases TV/DVD viewing.ObjectiveTo investigate the directional association between TV/DVD screen time and performance on developmental screeners in children aged 1 to 3 years.Design, Setting, and ParticipantsThis longitudinal cohort study analyzed data from 57 980 children and mothers from a national birth cohort, the Japan Environment and Children’s Study. Data were collected in collaboration with 15 regional centers across Japan. The mothers were recruited between January 2011 and March 2014. Analyses using random intercept, cross-lagged panel models were performed for children aged 1, 2, and 3 years. Of 100 303 live births, children with missing developmental screening test scores and screen time data, those with congenital diseases or cerebral palsy, and those diagnosed with an autism spectrum disorder were excluded. Statistical analyses were conducted from October 2022 to July 2023.ExposuresTV and DVD screen time.Main Outcomes and MeasuresChild development at ages 1, 2, and 3 years was assessed via the mother’s or guardian’s report using the Ages and Stages Questionnaire, third edition.ResultsOf 57 980 included children, 29 418 (50.7%) were male, and the mean (SD) maternal age at delivery was 31.5 (4.9) years. A negative association between screen time and developmental scores was observed. Increased TV/DVD screen times at age 1 and 2 years were associated with lower developmental scores at age 2 and 3 years, respectively (2 years: β = −0.05; 95% CI, −0.06 to −0.04; 3 years: β = −0.08; 95% CI, −0.09 to −0.06). An obverse association was observed from the Ages and Stages Questionnaires, third edition, score in the communication domain at age 1 and 2 years to subsequent screen time (2 years: γ = −0.03; 95% CI, −0.04 to −0.02; 3 years: γ = −0.06; 95% CI, −0.07 to −0.04).Conclusions and RelevanceIn this study, increased TV/DVD screen time from age 1 year negatively affected later development. To reduce the negative consequences of excessive media use, researchers and health care professionals should encourage family media management and recommend social support for parents who tend to rely on the media.
Adaptive fuzzy event‐triggered fault‐tolerant control of switched nonlinear systems with actuator failures under state‐dependent switchings
Authors: Zhang Ronghao , Li Shi , Chen Yongsheng , Liu Ye 
Published: September 2023

SummaryIn this article, an adaptive fuzzy event‐triggered control problem of switched nonlinear systems with actuator failures under state‐dependent switchings is studied. Fuzzy logic systems are introduced to approximate the unknown nonlinear terms of the system. To reduce the wastage of communication resources, an adaptive fuzzy event‐triggered fault‐tolerant controller with a state‐dependent switching law is designed. Moreover, a modified hybrid switching law is also provided to avoid the fast switching phenomenon. In order to ensure the stability of the whole system, the convex combination technology and single Lyapunov function method are adopted. It is proved that all signals of the closed‐loop system are bounded. Finally, the effectiveness of the method is verified by simulation results.
Highly Nonlinear Memory Selectors with Ultrathin MoS2/WSe2/MoS2 Heterojunction
Authors: Chen Hongye , Wan Tianqing , Zhou Yue , Yan Jianmin , Chen Changsheng , Xu Zhihang , Zhang Songge , Zhu Ye , Yu Hongyu , Chai Yang 
Published: September 2023

AbstractResistive random access memory (RRAM) crossbar arrays require the highly nonlinear selector with high current density to address a specific memory cell and suppress leakage current through the unselected cell. 3D monolithic integration of RRAM array requires selector devices with a small footprint and low‐temperature processing for ultrahigh‐density data storage. Here, an ultrathin two‐terminal n‐p‐n selector with 2D transition metal dichalcogenides (TMDs) is designed by a low‐temperature transfer method. The van der Waals contact between transferred Au electrodes and TMDs reduces the Fermi level pinning and retains the intrinsic transport behavior of TMDs. The selector with a single type of TMD exhibits a trade‐off between current density and nonlinearity depending on the barrier height. By tuning the Schottky barrier height and controlling the thickness of p‐type WSe2 in MoS2/WSe2/MoS2 n‐p‐n selector for a punch‐through transport, the selector shows high nonlinearity (≈ 230) and high current density (2 × 103 A cm−2) simultaneously. The n‐p‐n selectors are further integrated with a bipolar hexagonal boron nitride memory and calculate the maximum crossbar size of the 2D material‐based one‐selector one‐resistor according to a 10% read margin, which offers the possible realization of future 3D monolithic integration.