bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jasmonate signaling drives defense responses against Alternaria alternata in chrysanthemum
Authors: Zhang Shuhuan , Miao Weihao , Liu Ye , Jiang Jiafu , Chen Sumei , Chen Fadi , Guan Zhiyong 
Published: June 2023

AbstractBackground Black spot disease caused by the necrotrophic fungus Alternaria spp. is one of the most devastating diseases affectingChrysanthemum morifolium. There is currently no effective way to prevent chrysanthemum black spot. Results We revealed that pre-treatment of chrysanthemum leaves with the plant hormone jasmonate (JA) significantly reduces their susceptibility toAlternaria alternata. To understand how JA treatment induces resistance, we monitored the dynamics of metabolites and the transcriptome in leaves after JA treatment followingA. alternatainfection. JA signaling affected the resistance of plants to pathogens through cell wall modification, Ca2+regulation, reactive oxygen species (ROS) regulation, mitogen-activated protein kinase cascade and hormonal signaling processes, and the accumulation of anti-fungal and anti-oxidant metabolites. Furthermore, the expression of genes associated with these functions was verified by reverse transcription quantitative PCR and transgenic assays. Conclusion Our findings indicate that JA pre-treatment could be a potential orchestrator of a broad-spectrum defense response that may help establish an ecologically friendly pest control strategy and offer a promising way of priming plants to induce defense responses againstA. alternata.
Fungal Periprosthetic Joint Infection Following Total Knee Arthroplasty as Easily Overlooked but the Most Dreaded Complication: Case Report and Systematic Review
Authors: Xu Qibo , Xiao Jianlin , Xu Shenghao , Zhang Dongjie , Zuo Jianlin , Shen Xianyue 
Published: June 2023

AbstractBackground:Total knee arthroplasty is an effective procedure for the treatment of severe knee osteoarthritis. However, periprosthetic joint infection is one of the serious complications after arthroplasty. Most of the periprosthetic joint infections are caused by bacteria, while fungal periprosthetic joint infection is rare, accounting for about 1% of the total number of periprosthetic joint infections. Currently, there is a lack of reliable systemic and topical antifungal drugs, and no international guidelines have yet defined a gold standard for the medical and surgical treatment of fungal periprosthetic joint infection following total knee arthroplasty.Methods:In this paper, we report of a case of fungal periprosthetic joint infection healed with debridement, antibiotics and implant retention after total knee arthroplasty. At the same time, we searched PubMed, Embase, and Google Scholar for fungal periprosthetic joint infection following total knee arthroplasty between January 1980 and August 2022.Results:Forty-nine full-text articles and 62 finished cases were included for comparison with the present case. In all 63 included cases, 18 fungal pathogens were identified. Thirty-nine patients (62%) had other comorbidities or risk factors. For patient symptoms, pain (47/63) was the most common, followed by swelling (40/63) and localized skin warmth (12/63).Candida parapsilosiswas the most common fungal pathogen, with 22 positive cultures, followed byCandida albicanswith nine positive cultures. Forty-one patients were treated with two-stage revision arthroplasty or one-stage revision arthroplasty. The results showed that of 32 patients who underwent two-stage revision arthroplasty, 28 patients were successfully treated, three patients had controlled infections awaiting prosthetic reimplantation, and one patient had mild postoperative pain. Of nine patients who underwent one-stage revision arthroplasty, eight patients were successfully treated, and one had infection recurrence. Overall, two-stage revision arthroplasty could be considered the better choice.Conclusions:Fungal periprosthetic joint infection is a rare complication of total knee arthroplasty. It lacks specific clinical manifestations, but it can lead to severe debilitating symptoms and impaired patient function.Candidais the most common cause. A fungal culture is difficult yet critical. Two-stage revision arthroplasty is the most used surgical treatment, offering a higher chance of success, but it is still controversial.
Immediate and Delayed Effects of Environmental Temperature on Schizophrenia Admissions in Liuzhou, China, 2013–2020: A Time-Series Analysis
Authors: Zhou Qian , Huang Xiaolan , Su Li , Tang Xianyan , Qin Yanli , Huo Yuting , Zhou Chun , Lan Jun , Zhao Yue , Huang Zaifei , Huang Guoguang , Wei Yuhua 
Published: June 2023

Abstract
This study aimed to investigate the associations between environmental temperature and schizophrenia admissions in Liuzhou, China. A Poisson generalized linear model combined with a distributed lag nonlinear model was used to analyze the effects of daily mean temperature on schizophrenia admissions from 2013 to 2020 in Liuzhou. Additionally, subgroup analyses were conducted to investigate possible modifications stratified by gender, marital status, and age. In this study, 10,420 schizophrenia admissions were included. The relative risks of schizophrenia admissions increased as the temperature rose, and the lag effects of high temperature on schizophrenia admissions were observed when the daily mean temperature reached 21.65℃. The largest single effect was observed at lag0, while the largest cumulative effect was observed at lag6. The single effects of high temperatures on schizophrenia admissions were statistically significant in both males and females, but the cumulative effects were statistically significant only in males, with the greatest effect at lag0–7. The single effect of high temperatures on admissions for unmarried schizophrenics was greatest at lag5, while the maximum cumulative effect for unmarried schizophrenia was observed at lag0–7. The single effects of high temperatures on schizophrenia admissions were observed in those aged 0–20, 21–40, and 41–60. The cumulative effects for schizophrenics aged 21–40 were observed from lag0–3 to lag0–7, with the maximum effect at lag0–7. In conclusion, the risk of schizophrenia admissions increased as the environmental temperature increased. The schizophrenics who were unmarried appeared to be more vulnerable to the single and cumulative effects of high temperature.
National and Local Diagnostic Reference Levels for 18F-FDG and CT in Jordanian PET/CT Scanning: Findings and Implications in Practice
Authors: Alhorani Qays , Alkhybari Essam , Rawashdeh Mohammad , Latiff Rukiah A. , Sabarudin Akmal , Al-Ibraheem Akram , Mohamad Mazlyfarina 
Published: June 2023

Abstract
Background
Positron emission tomography-computed tomography (PET/CT) is a widely utilized hybrid imaging technique that combines functional and anatomical information. To ensure the safe and effective use of this imaging modality, Diagnostic Reference Levels (DRLs) have been established as standardized benchmarks for assessing and managing radiation doses in clinical practice. Several studies have reported DRLs for different radiotracers and imaging modalities, including PET/CT. However, there is a need for country-specific DRL data that reflect national clinical practices. While existing literature provides insights into DRLs for PET/CT procedures in various settings, there is a lack of PET/CT DRLs specific to the Jordanian context. Given the variations in patient populations, equipment specifications, and clinical protocols, it is crucial to establish NDRLs and local DRLs (LDRLs) in Jordan. Therefore, the study aimed to derive the country-specific reference levels for fluoride-18 fluorodeoxyglucose (18F-FDG) PET/CT scans in Jordan.
Results
The survey revealed that Jordanian NDRL for administered activity (AA) (303 MBq) was within the acceptable range compared to the published-peer NDRL data (240 to 590 MBq). However, the 18F-FDG AA varied across the participated PET/CT centres. The reported LDRL CTDIvol and DLP of CT used for attenuation correction and anatomical localization (AC-AL) was 4.3 mGy and 459.3 mGy.cm for half-body (HB) CT scan range, and 4.05 mGy and 659.9 mGy.cm for whole-body (WB) CT scans. The reported LDRL for CTDIvol and DLP for HB CT was higher when compared with the United Kingdom (3.2 mGy and 310 mGy.cm). Meanwhile, it remained higher than both Kuwait (3.6 mGy and 659 mGy.cm) and Slovenia (3.6 mGy and 676 mGy.cm) for WB CT. The reported HB attenuation correction diagnostic CT(AC-DX) CT was higher than previously identified peer-reviewed NDRL data and lower than Slovenia for WB AC-DX CT acquisition protocols.
Conclusion
This study reported the first Jordanian NDRL for 18F-FDG and LDRL for HB and WB CT associated with 18F-FDG PET/CT scans. The data provides a valuable reference point for Jordanian PET/CT centres to compare their LDRL with the suggested DRLs. By utilizing this data, centres need to optimize CT radiation doses and tailor them to ensure appropriate image quality.
Novel nomogram based on routine blood and urine parameters for customized prediction in recurrence of primary non-muscle-invasive bladder cancer
Authors: He Yi , Pan Chenxi , Zhang Yue , Yang Bo 
Published: June 2023

Abstract
Purpose
A prevalent condition with a high probability of recurrence, non-muscle invasive bladder cancer (NMIBC) necessitates lifetime surveillance. In patients with pathologically confirmed NMIBC, our goal was to create a unique nomogram to predict recurrence after transurethral resection of bladder tumor (TURBT).
Methods
Our institution's 91 NMIBC patients with complete follow-up data between January 2017 and February 2021 were included in the retrospective analysis. The nomogram predicting the 0.5, 1, 2 and 3-year likelihood of recurrence was created using multivariate Cox proportional hazard models to find the significant determinants of recurrence. Using the concordance index (C-index), calibration curves, receiver operating characteristic (ROC) curves, and decision curve analyses (DCA), we internally validated the nomogram.
Results
The significant factors related to NMIBC recurrence were age, blood platelet count, especially for the urine leukocyte count and mucus filament. The constructed nomogram performed well in the customized prediction of NMIBC recurrence at 6th, 12th, 24th and 36th month, of which the C-index was 0.724. The calibration curve and the ROC curve both validated the prediction accuracy. On DCA, the nomogram presented good net benefit gains across a wide range of threshold probabilities. Furthermore, the Nomogram-related risk score was used to divide the patient population into two groups with significant recurrence disparities.
Conclusion
For the prediction of NMIBC recurrence, our unique nomogram demonstrated a respectable degree of discriminative capacity, sufficient calibration, and considerable net benefit gain. There will be a need for additional internal and external validation.
Missing-value Imputation of Environment Sensors Using Multilayer Stacking with Scoring Method
Authors: Chun Hyeonu , Cho Jaehyuk 
Published: June 2023

Abstract
While analyzing environmental data, missing data reduce the predictive power of the model, and imputing missing data to the algorithm biases the parameter estimation, thereby increasing the uncertainty of the results. This study introduces a missing data handling model based on multilayer stacking by synthesizing the characteristics of missing data handling. The model utilizes an ensemble technique to integrate the advantages of existing models, and the final meta learner of the ensemble model is augmented with data fusion data using a Kalman filter for training data and add the features of sensor fusion for multiple identical characteristics to the model. In a situation that includes the types of missing data used in the study, the method of generating new learning data by collecting weights based on the scoring method and weighting the existing learning data has the effect of matching the measurement environment. The performance of the model improved by 20% compared with existing models utilized as nodes in an environment where normal values and various types of defects were combined. In addition, the performance improved by 30% compared with the multiple imputation by chain equations (MICE) and the single center imputation from multiple chained equations (SICE) models, which are commonly used in other sensor data with defects within a sensor group, and stable results were obtained. This shows that the proposed model reduces the cost of determining the model for various errors that may occur in environmental sensors, and, by checking how sensitive the model is to different patterns of missing data, it can be applied in various environments and improved using advanced node models in the future.
Uptake and availability of new outpatient cancer medicines in 2010-2021 in Nordic countries – Survey for competent authorities
Authors: Sarnola Kati , Koskinen Hanna , Klintrup Katariina , Astrup Cecilie , Kurko Terhi 
Published: June 2023

Abstract
Background: Nordic countries excel in cancer care, but studies on uptake, costs, or managed entry agreements of cancer medicines have not been conducted in Nordiccountries recently. The aim of this study was to examine the uptake and availability of orally administered new cancer medicines in Nordic countries. Firstly, we studied the distribution, costs and adoption of managed entry agreements of cancer medicines in general, and secondly, uptake of, and adopted managed entry agreements for orally administered cancer medicines, used in the outpatient care, that were granted marketing authorization in Europe in 2010–2021.
Methods: E-mail survey for competent authorities in Denmark, Finland, Iceland, Norway, and Sweden in April-June 2022. The data were analysed using frequencies and percentages for descriptive analysis.
Results: The distribution of cancer medicines is somewhat uniform in Finland, Iceland, Norway, and Sweden, where cancer medicines can be distributed both via hospitals or hospital pharmacies for inpatient use, and via community pharmacies for outpatient use. In Denmark, cancer medicines are predominantly distributed via publicly funded hospitals. In all countries that provided data on the costs, the costs of cancer medicines had notably gone up from 2010 to 2021. The number of reimbursable medicines out of new cancer medicines varied from country to another, but the majority of medicines were reimbursed in most Nordic countries. Managed entry agreements, often with confidential discounts, were in use in all Nordic countries, but the number of agreements and the cancer types, for which agreements were most often made, varied. Average days from authorization to reimbursement of new cancer medicines also varied from an average of 416 to 895 days.
Conclusions: Nordic countries share similar characteristics but also differ in terms of the details in distribution, adopted managed entry agreements, market entry, and availability of new cancer medicines used in the outpatient care. The costs of cancer medicines have increased in all Nordic countries during the last decade. Due to differences in health care and because orally administered cancer medicines can be dispensed at community and hospital pharmacies, the number of reimbursable medicines and managed entry agreements vary between countries. However, Nordic countries mainly seem to agree in entry and reimbursement decisions of novel cancer medicines.
Comparison of the Visual Performances of Diffractive EDOF Lenses, Bifocal Intraocular Lenses with a 3.5 D Addition and Their Combination
Authors: Zhou Xiyue , Fan Fan , Yang Tianke , Yang Jianing , Liu Xin , Luo Yi 
Published: June 2023

Abstract
Background: To compare the visual performances of diffractive extended depth of focus (EDOF) lenses, diffractive bifocal intraocular lenses (IOLs) and their combination.
Methods: This was a prospective, consecutive observational comparative study. Thirty patients (60 eyes) were included in the binocular Diff-aAY group and received bilateral implantation of diffractive bifocal IOLs (Human Optics Diff-aAY). Twenty-nine patients (58 eyes) in the binocular Symfony group received EDOF lenses (Tecnis Symfony ZXR00). The mix-and-match group included 27 patients who received a Symfony IOL in one eye and Diff-aAY IOL in the other eye. Follow-ups were scheduled at 1 day, 3 days, 2 weeks and 6 months. Visual acuities at different distances were examined at every follow-up. At 6 months, defocus curves, optic path difference (OPD) scans, and questionnaire answers were evaluated.
Results: There was no significant difference in binocular UIVA, UNVA, or CDVA among the three groups (P=0.079, 0.147 and 0.696, respectively). The mix-and-match group had a superior SR (P=0.027) and MTF (P<0.001) and an inferior RMS (P<0.001). The binocular Symfony and mix-and-match groupsdemonstrated a smoother defocus curve. The three groups reported the same level of postoperative satisfaction (P=0.141) and spectacle independence (P=0.278). Overall, 70.37% of the mix-and-match group had complete spectacle independence, which was higher than that in the other two study groups.
Conclusions: Symfony and Diff-aAY both proved to be remarkable regarding distance, intermediate and near vision. The combination of these two IOLs achieved better objective visual quality and spectacle independence but more subjective dysphotopsia, This provides a new and effective option for patients with high visual quality needs.
Analysis of the properties of 0.2C-4Al-1.2Mn TRIP-assisted Steel subjected to Mo micro-alloy and isothermal bainitic transformation (IBT) time
Authors: Gholambargani Mahsa , Palizdar Yahya , khanlarkhani Ali , najafi soroush 
Published: June 2023

Abstract
In this investigation, the results of the experiment in which two samples of TRIP-assisted steel were micro-alloyed with 0.05 and 0.30 wt.% Mo addition in combination with isothermal bainitic transformation (IBT) time parameters was analyzed and evaluated. Microstructures were studied using optical microscope (OM) and field emission scanning electron microscope (FE-SEM) equipped with an energy dispersive X-ray spectrometer (EDX). Using X-ray diffraction (XRD), the retained austenite (RA) phase volume percentage was calculated. The studied steels had a multi-phased structure including δ-ferrite as the matrix phase and α-ferrite, bainite, and RA along with some martensite. The quantity of RA and its morphology in the microstructure of the samples are key factors in achieving desirable combinations of mechanical characteristics (high strength and acceptable ductility).
Yield stresses of 400-440 MPa, tensile strengths of 790-870 MPa, and elongations to failure of 24-34% were observed in TRIP-assisted steels containing 0.05 and 0.30 wt.% Mo-alloy. It was determined that the best UTS×TE was (850MPa×32%) 27200 MPa.%, with 0.30 wt.% Mo addition and IBT temperature and time of 450 ℃ and 10 minutes.
Development of a methodology for material removal factor (fab) repeatability improvement in a single scratch test
Authors: Borges Elsio Junior Bonati , Teles Vinícius Carvalho , Júnior Washington. Martins Silva , Silva Leonardo Rosa Ribeiro , Arencibia Rosenda Valdés 
Published: June 2023

Abstract
Scratch testing quantifies single-point abrasion resistance, but precise material removal factor (fab) values remain challenging. This study proposes a robust methodology for improving fab repeatability. Thorough investigation identified factors contributing to low repeatability. Standardized protocols for sample preparation, testing, and area measurement were developed. Using the GUM method, measurement uncertainty was determined. Fab evaluation on a grade 0 gauge block showed excellent repeatability. The worst-case standard deviation was 8% with a Rockwell C indenter and 12% with a Vickers indenter, primarily due to material pile-up and chip formation. Topographic inhomogeneity significantly affected fab variability. These findings emphasize the importance of accurate and repeatable fab values for enhanced abrasion modeling and material characterization.
Inhibition of Aquaporin-4 and its sub-cellular localization attenuates below-level central neuropathic pain via regulating astrocyte activation in a rat spinal cord injury model
Authors: Song Yu , Xue Tao , Guo Shiwu , Yu Zhen , Yun Chengming , Zhao Jie , Song Zhiwen , liu zhiyuan 
Published: June 2023

AbstractThe mechanisms of central neuropathic pain (CNP) caused by spinal cord injury have not been sufficiently studied. We have found that the up-regulation of astrocytic Aquaporin-4 (AQP4) aggravated peripheral neuropathic pain after spinal nerve ligation in rats. Using a T13 spinal cord hemisection model, we showed that spinal AQP4 was markedly up-regulated after SCI and mainly expressed in astrocytes in the spinal dorsal horn (SDH). Inhibition of AQP4 with TGN020 suppressed astrocytes activation, attenuated the development and maintenance of below-level CNP and promoted motor function recovery in vivo. In primary astrocyte cultures, TGN020 also changed cell morphology, diminished cell proliferation and suppressed astrocyte activation. Moreover, T13 spinal cord hemisection induced cell-surface abundance of AQP4 channel and the perivascular localization in the SDH. Targeted inhibition of AQP4 sub-cellular localization with trifluoperazine effectively diminished astrocytes activation in vitro and further ablated astrocytes activation, attenuated the development and maintenance of below-level CNP, and accelerated functional recovery in vivo. Together, these results provide mechanistic insights into the roles of AQP4 in the development and maintenance of below-level CNP. Intervening with AQP4, including targeting AQP4 subcellular localization, might emerges as a promising agent to prevent chronic CNP after SCI.
Assessing Sustainability of Chiang Mai Urban Development
Authors: Pongruengkiat Wiwat , Tippayawong Korrakot Y. , Aggarangsi Pruk , Pichayapan Preda , Katongtung Tossapon , Tippayawong Nakorn 
Published: June 2023

Abstract
Sustainable urban development is an increasingly important concept as cities around the world continue to grow and face challenges related to urbanization, including environmental degradation, social inequality, and economic instability. Chiang Mai is a rapidly growing city in Thailand that steers towards sustainability. In this work, we examine the state of sustainable urban development in Chiang Mai by analyzing various indicators, including transportation, waste management, air quality, and energy consumption. A multi-dimensional framework was used to assess the sustainability of Chiang Mai. Our analysis suggests that while Chiang Mai has made progress in some areas of sustainable urban development, such as promoting green transportation and waste reduction and reduction consumption, there are still many challenges to be addressed, particularly in air pollution, water management, transportation and energy consumption. We conclude by discussing the implications of our findings for policy makers, urban planners, and other stakeholders interested in promoting sustainable urban development. This study assesses Chiang Mai's sustainability using a comprehensive set of 35 indicators. It was found that Chiang Mai has potential for sustainable development, but some indicators require improvement. The study presents guidelines for prioritizing sustainable development, improving air and water quality, promoting sustainable tourism, enhancing waste management, transportation management and energy consumption. This research provides alternative framework for evaluating cities and presents a valuable contribution to the field of sustainable urban development.