bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nintedanib as the First Treatment for Group of Progressive Interstitial
Lung Diseases: A Review of Patent Literature
Authors: Trivedi Madhavkumar Dilipbhai , Dubal Gaurang , Vora Pratik Ashwinbhai 
Published: September 2023

Abstract:
Nintedanib is a competitive inhibitor of non-receptor tyrosine kinase (nRTKs) and receptor
tyrosine kinase (RTKs). Nintedanib is a substrate for the P-glycoprotein transporter, which
returns ingested substances to the gastrointestinal lumen. At present, Nintedanib is being prescribed
for individuals diagnosed with idiopathic pulmonary fibrosis (IPF). This assessment provides
a concise overview of the latest patents pertaining to Nintedanib. The patents covered in this
analysis are categorized into sections, including patents related to the active ingredient, polymorph,
formulation, and treatment method. The purpose of this compilation is to offer researchers
convenient access to all the relevant patents in a single resource. Information was collected from
diverse web databases, including both paid and free sources. Paid databases, such as Orbit® and
SciFinder® were utilized as examples. On the other hand, free databases, such as the European
Patent Office's Espacenet®, WIPO Patentscope® the Indian patent database, and Google Patents,
were also accessed for data gathering purposes. The orange-book listed patents for Nintedanib are
set to expire in July 2029. These patents explore various excipients to address the solubility issue
in the long-term storage of the formulation. However, despite these efforts, there is still a need for
further research to enhance the properties of the Nintedanib formulation. Extensive research has
been conducted on multiple methods for manufacturing Nintedanib and its formulations. This
dynamic study has the potential to create opportunities for numerous generic companies to
enter the United States market. This, in turn, will improve healthcare accessibility by lowering
costs.
Therapeutic Importance and Pharmacological Activities of Norisoboldine
in Medicine for the Treatment of Human Disorders
Authors: Patel Dinesh Kumar , Patel Kanika 
Published: September 2023

Background:
Natural products constitute a unique source of chemical compounds with vast multi-target potential for the treatment of complex human disorders. Phytochemicals are pure phytoconstituents of plants, mainly responsible for their therapeutic potential and pharmacological activities. Natural products isolated from medicinal plants have been used as a lead source of drug. Norisoboldine is an important isoquinoline alkaloid found to be present in the dry root of Lindera aggregate.

Methods:
In the present paper, scientific data of norisoboldine have been collected from Google, Google Scholar, PubMed, Science Direct and Scopus and analyzed in order to know the biological potential and therapeutic effectiveness of norisoboldine in medicine. Scientific data of medicinal importance and therapeutic potential of norisoboldine has been collected and analyzed in the present work. Moreover, all the collected scientific data have been separated into different sub-section i.e. Medicinal importance, pharmacological activities and analytical aspects. Detailed pharmacological activity data of norisoboldine have been analyzed in the present work to know the therapeutic effectiveness of norisoboldine in medicine. Analytical data of norisoboldine have also been collected and analyzed in the present work.

Results:
Scientific data analysis revealed the biological importance of isoquinoline alkaloids in medicine. Isoquinoline alkaloids are pure, active phytochemical present in several natural edible products including vegetables, plants, and fruits. Norisoboldine has a biological effect on arthritis, colitis, apoptosis, osteoclast differentiation, inflammatory pain, renal ischemia-reperfusion injury, acute lung injury, pro-inflammatory cytokines, tumor, regulatory T cells, and endothelial cell migration. However nanoemulsifying drug delivery system of norisoboldine has also been prepared in order to get better therapeutic value. Further analytical parameters of norisoboldine were also discussed in the present work in order to get the scientific information of separation, isolation and identification parameter of norisoboldine.

Conclusion:
Present work revealed the therapeutic potential of norisoboldine in medicine.
تحلیل الکفاءة الانتاجية والاقتصادية لنظم انتاج محصول الخيار في محافظة السلیمانیة للموسم الزراعي (2021_2022)
Authors: Aziz Nigar Jebar , Huseen Khalid Mohammad 
Published: September 2023

يسعى الدراسة الى تحليل الكفاءة الانتاجية والاقتصادية لمحصول الخيار وتقييم نظم الانتاج الثلاث (نظام المكشوف –الزراعة التقليدية، الزراعة بنظام البيوت البلاستيكية ، نظام الزراعة بالانفاق البلاستيكية) المختلفة اقتصاديا في محافظة السليمانية . وذلك باستخدام بيانات اولية (مباشرة) تم تجميعها لعينة من مزارعي (منتجي) محصول الخيار في النظم الثلاثة في الموسم الزراعي 2021-2022.
توصلت الدراسة الى تحديد العناصر الانتاجية الاكثر اهمية والاكثر تاثيرا بانتاج محصول الخيار المنتج بنظم الانتاج الثلاثة وهما كل من السماد العضوي والسماد النتروجيني ، وقد تم تقدير دالة الاستجابة المحصولية المقدرة واشتقاق دالة منحى الناتج المماثل وخط منحى التوليفات الاقل تكلفة . وجد الانتاج الفعلي لمحصول الخيارفي محافظة السليمانية يتم في مرحلة الانتاج الاولي مرحلة (غير اقتصادية) في النظم الثلاثة حيث بلغ حوالي 16 طن للدونم في حالة الزراعة المكشوفة ونحو(40 طن للدونم) في نظام الزراعة بالبيوت البلاستيكية ونحو(24 طن للدونم) في حالة نظام الزراعة بطريقة الانفاق.قدر صافي العائد المتحقق للطن حوالي (9934 الف دينار) في نظام الزراعة بالبيوت البلاستيكية ثم ياتي الانتاج في نظام الانفاق بصافي عائد للطن حوالي (3511 الف دينار) وجاء مستوى الكفاءة الاقتصادية لمحصول الخيار في نظام الزراعة المكشوفة اقل بالمقارنة بالنظامين السابقين حيث قدر عائد الطن من محصول الخيار بحوالي (1231 الف دينار) فقط .
توصي الدراسة بالاستخدام الامثل للكميات المثلى الاقتصادية من عنصري الانتاج السماد العضوي والسماد النتروجيني كونهما من العناصر الفعالة لزيادة الانتاج
لمحصول الخيار في النظم الثلاثة ، وذلك من خلال زيادة كفاءة استخدامهما بهدف الوصول الى الحجم الاقتصادي وتقليل الخسارة التي يتكبدها المزارع بسبب الانتاج بمرحلة غير اقتصادية ( المرحلة الاولى ) .
Susceptibility Screening of Winterberry Cultivars Against Latent Fruit Rot, and Identification of Metabolites Correlated with Rot-resistant Phenotypes
Authors: Emanuel Isabel B. , Cooperstone Jessica L. , Hand Francesca Peduto 
Published: September 2023

Abstract
Winterberry [Ilex verticillata (L.) A. Gray] is a species of deciduous holly bearing colorful fruit, and is popularly used in landscape design and as specialty woody cuts for fall and winter seasonal decoration. Latent fruit rot of winterberry, caused by the fungus Diaporthe ilicicola, has recently afflicted nurseries in the Northeastern and Midwestern United States. Trials conducted in 2021 and 2022 screened eight commercially available winterberry cultivars for their susceptibility to the disease. Results showed that not all cultivars are equally susceptible, and that ‘Maryland Beauty’ and ‘Winter Red’ consistently had the lowest disease ratings. UHPLC-MS/MS metabolomic analysis was used to determine whether differences in susceptibility are reflected in the fruit metabolome. Principal components analysis of whole metabolome data showed a distinct separation of the less susceptible cultivars from the more susceptible cultivars, and univariate analysis comparing these two groups of cultivars at three phenological timepoints (corresponding with fruit set, fruit color change, and fruit maturation) found 89 features present at a significantly higher relative abundance in the less susceptible cultivars. Some compounds identified in less susceptible cultivars with reported antifungal bioactivity are derivatives of terpenes, cinnamic acids, and stilbenes. These results suggest that differences in susceptibility could be based on the presence of antifungal compounds within winterberry fruit. Future research to further identify unknown features and assess compound bioactivity against winterberry fruit rot pathogens should be done to inform both resistance breeding efforts and chemical or biological control programs.
Species used in this study: Common winterberry [Ilex verticillata (L.) A. Gray]; Diaporthe ilicicola S. Lin, Taylor & Peduto Hand, 2018.
Assessing Ecological Impacts of Cultivated Hybrids of Milkweed (Asclepias)
Authors: Peterman Justin , Fair Conor , Brown Hannah , Braman Kris , van Iersel Marc W. 
Published: September 2023

Abstract
Increased efforts to use native plants to provide ecosystem services in urban landscapes have led to breeding efforts to increase access to native plants in horticulture markets. Inadvertent ecological impacts however should be assessed prior to market release. Here we trial new interspecific hybrids of milkweed to assess outcrossing into natural populations and support for pollinating species. Interspecific hybrids of Asclepias were unable to successfully fertilize A. tuberosa, indicating minimal likelihood of outcrossing into natural populations. Hybrids lacked self-fertilization and the ability to cross with full-siblings, indicating low levels of establishment of the interspecific hybrids into natural environments. Nectar composition and nectar concentration were similar among hybrids and A. tuberosa, revealing there was not a loss in floral rewards, despite trait selection for horticulturally preferable traits. Pollinator abundance was higher on hybrids than on A. tuberosa, and richness and diversity of pollinator species were similar among hybrids and A. tuberosa, indicating that the hybrids can offer similar or more ecosystem services as A. tuberosa. New interspecific hybrids of Asclepias selected for horticulturally preferable traits have shown ecological value similar to A. tuberosa with respect to supporting pollinating species and minimal ecosystem impact for natural populations of A. tuberosa.
Species used in this study: butterfly weed (Asclepias tuberosa L.); tall green milkweed [Asclepias hirtella (Pennell) Woodson]; common milkweed (Asclepias syriaca L.); showy milkweed (Asclepias speciosa Torr.); purple milkweed (Asclepias purpurascens L.); Asclepias tuberosa × hirtella; Asclepias tuberosa × syriaca; Asclepias tuberosa × speciosa; Asclepias tuberosa × purpurascens.
Serum calcium concentrations are inversely correlated with pancreatic lipase concentrations in dogs
Authors: Cridge Harry , Wang Sichao , Steiner Joerg M. 
Published: September 2023

Abstract

OBJECTIVE
(1) Determine if a relationship exists between ionized calcium (iCa) and pancreatic lipase (cPLI) concentration in dogs, and (2) assess for correlation between resolving hypercalcemia and cPLI concentrations in dogs after treatment for primary hyperparathyroidism (PHPT).

SAMPLES
Phase I, 44 residual serum samples (collected April 2023) from client-owned dogs with a clinical indication for cPLI quantification. Phase II, 24 residual serum samples (collected August 2022 through February 2023) from client-owned dogs with PHPT pre- and postcorrection of hypercalcemia.

METHODS
Serum cPLI and iCa concentrations were measured via the Spec cPL assay and a spectrophotometric method respectively. Spearman’s rank correlation coefficients were used to investigate if there was a correlation between serum calcium and cPLI concentrations. A paired t-test was used to investigate the effect of the resolution of hypercalcemia on serum cPLI concentrations.

RESULTS
Phase I, serum cPLI concentrations were negatively correlated with serum iCa concentrations (r = −.429, 95% CI [−.64, −.14], P = .005) in dogs with a clinical indication for cPLI quantification. Phase II, median serum cPLI concentrations were higher before (median: 228.5 μg/L, IQR: 351.3 μg/L) than after (median: 141.0 μg/L, interquartile ranges (IQR): 279.5 μg/L) management of hypercalcemia (PHPT model). However, the decrease in cPLI concentration was not statistically significant (P = .70).

CLINICAL RELEVANCE
Calcium depletion may result in an inverse relationship between serum cPLI and iCa concentrations in dogs with a clinical indication for cPLI quantification. Hypercalcemia may be associated with an above reference interval cPLI concentration in some dogs.
A Multiple Unit Abuse-deterrent Dosage Form Based on Sodium Alginate
Authors: Papadakos M. , Špaglová M. , Čuchorová M. , Hanko M. 
Published: September 2023

Abstract
There are several approaches for the formulation of abuse-deterrent, tamper-resistant, or alcohol-resistant dosage forms. This work is specifically focused on the formulation of microforms and multiple unit dosage forms with the mentioned resistant features. We prepared microcapsules based on sodium alginate by Ca2+-induced gelation, containing caffeine as a model drug. The prepared microcapsules were dried either by hot air or freeze-dried and the resistance in an alcoholic environment and the resistance against mechanical stress were observed. Subsequently, swelling studies were conducted to predict the behavior of prepared microcapsules during dissolution testing. Differences in the behavior of microcapsules during dissolution testing were strongly related to the different abilities of Ca2+-alginate microcapsules to swell in an acidic and alkaline environment. Alginate microcapsules exhibited gastro-resistant properties due to excellent swelling in an alkaline environment and poor swelling in a gastric environment. The addition of ethanol did not influence the swelling behavior of alginate microcapsules in the gastric fluid; rather, it showed the opposite effect, where swelling was slightly suppressed. Therefore, we conclude that alginate microcapsules are alcohol resistant. Also, they showed high mechanical strength, and therefore, grinding the microcapsules into a powder was impossible.
Lean Manufacturing and Operational Performance: An Empirical Study on an Apparel Manufacturing Company
Authors: De Silva Pubudika Isurini , Seneviratne S M Chaturika 
Published: September 2023

Purpose – The present study aims to explore how a firm implements lean management practices by utilizing firm specific resources and their influence on the operational performance of an apparel manufacturing company. Design/Methodology/approach – The paper uses a single case, in depth study approach based on a Sri Lankan apparel manufacturing company. Data are collected using interviews, observations and documentary evidence. Findings – The research study found that lean manufacturing considerably impacts to enhance the firm’s operational performance through improved quality, reduced cost, improved safety, increased speed, and improved moral. The case data suggested around twenty-five lean practices suitable to be implemented by a selected apparel manufacturing company and gain a competitive advantage in the contemporary market. Through the analysis, it was found that contribution of organizational resources and technology resources of a firm are essential to sustain the gained competitive advantage through lean manufacturing, confirmed by the assessment of the criteria of value, rare, inimitability and non-substitutability. Research Limitations/Implications – As the research is directed towards the apparel manufacturing industry in Sri Lanka, the applicability of the findings may cause adversity for other manufacturing industries, broadening the scope of future research. Practical Implications – As an extension to the lean manufacturing compositions, the findings of the study will have pragmatic implications to operational managers and executives involved in developing and implementing lean strategies, particularly in terms of applicable lean practices and key strategic resources to sustain the competitive edge through lean implementation. Originality/Value – This study contributes to the literature on strategic management by documenting the impact of lean manufacturing on operational performance in the Sri Lankan context through Resource-Based View approach, such interrelated theoretical insights are vital to gain a sustained competitive advantage.
Corporate Governance and Audit Report Lag in Non-Financial Companies on the Indonesia Stock Exchange
Authors: Sudradjat Sudradjat , Mai Muhamad Umar 
Published: September 2023

Purpose– This study aims to examine the effect of corporate governance on audit report lag. Corporate governance is proxied by the variable board of directors size, independent board of commissioners, female board of directors, external auditor reputation (Big 4), and audit committee size. The sample of this research is manufacturing companies that are listed consecutively on the Indonesia Stock Exchange during the period 2014 to 2020. Design/Methodology– The results of data collection indicate that the sample that meets the criteria is 86 firm-years, or 602 observations. The data analysis method used panel data regression. Results– The results showed that the board of directors size, Big 4, and audit committee size had a negative effect on the Audit Report Lag (ARL). Furthermore, the independent board of commissioners has a positive effect on ARL, while the female board of directors has no effect on the Audit Report Lag (ARL). Contribution– This research contributes to the development of corporate governance theory in relation to audit report lag. The results of this study can add insight and direction to reduce audit report lag for regulators, management, and investors on the Indonesia Stock Exchange, especially for manufacturing companies.
Identifying Key Service and Quality Dimensions as Public Relations Strategy in RSUP Persahabatan
Authors: Soleha Soleha , Utomo Anggayuh Gesang , Herari Noprita 
Published: September 2023

This study aims to determine the Application of the SERVQUAL Model to the PENCILS Public Relations Strategy at KS Hukormas (Organizational Legal Substance and Public Relations Substance Group) Persahabatan Hospital. The importance of the existence of public relations in health institutions, not only as forming a positive image of the hospital in synergy with internal and external customers, but also playing an active role in managing various health issues through community-focused activities. The dimensions of service quality (SERVQUAL) consisting of Tangible, Assurance, Reliability, Responsiveness and Empathy (TARRE), are parameters in the KS Hukormas RSUP Persahabatan in carrying out PR activities through the PENCILS strategy (Publications, Events, News, Community Involvement, Lobbying and Negotiation and social responsibility). This descriptive qualitative research uses multiple methods in data collection: observation, interviews and literature study. The results of the study show that although all aspects of TARRE have been fulfilled in PENCILS activities, the internal opinion of the RSUP Persahabatan considers that several aspects still need to be optimized and varied so that they are more interesting and not monotonous.
Keywords: SERVQUAL Model, PENCILS PR Strategy, Hospital Public Relations, Health Communication
Family Communication Between Single Father And Daughter In Affection Exchange
Authors: Deivita Monica Tyas Cahya 
Published: September 2023

The phenomenon of single fathers experiencing divorce and death has its own challenges in carrying out duties and responsibilities as parents, especially in taking care of adolescent girls, in which case adolescence is a transitional period towards adulthood so communication of affection is needed within the family. Researchers focused on families of single fathers and adolescent girls in the Special Region of Yogyakarta. This study uses a naturalistic paradigm. The data obtained in this study were obtained through observation, in-depth interviews, and documentation from the six key informants, namely single fathers and adolescent daughters, two supporting informants, and one expert informant. In this study, researchers found that family communication affects the form of messages that are produced in a form of exchange of affection, which can be in the form of verbal communication and nonverbal communication in relation to the exchange of affection and parenting patterns of single fathers. In addition, single fathers who communicate affection with their children have lower levels of stress and conflict avoidance than single fathers who do not communicate affection with their children. Therefore, affectionate communication contributes to the family because it can minimize conflicts that may occur between single fathers and adolescent girls.
Keywords: Affection Exchange, Family Communication, Single Father, Adolescent Girls
Combination Treatment for Hidradenitis Suppurativa
Authors: Mostafa Niyaz , Phan Kevin , Yazdabadi Anousha 
Published: September 2023

Background: The treatment of hidradenitis suppurativa remains challenging, despite recent advances. A diverse range of management options, from lifestyle measures to monoclonal antibodies, are available and utilized based on disease severity and other patient factors. Increasingly, it is thought that combination therapy may be more adept in meeting the challenges of treatment of this multimodal disorder.
Methods: A literature review of existing studies was performed. Eligible studies for the present review included case reports, case series, cohort studies or clinical trials in which patients with hidradenitis suppurativa were treated with a combination of two or more medical treatments. Abstracts, conference presentations, editorials, reviews, and expert opinions were excluded from analysis.
Results: A total of 19 studies were identified from systematic database searches after applying inclusion and exclusion criteria. The majority of treatments documented are systemic antibiotic combinations, however a minority relate to topical and biological agents. The treatment combinations had varying degrees of efficacy.
Conclusion: There is evidence that combination therapy is effective in the treatment of hidradenitis suppurativa. However the data is limited, and further, more robust, prospective studies with larger cohorts are required to reaffirm the findings in the present review.
Tibial Malrotation after Intramedullary Locked Tibia Nailing and its Computed Tomography-Based Assessment
Authors: Rathore Lakshya Prateek , Thakur Sanjay Kumar , Thakur Amit , Mahant Sucheta 
Published: September 2023

Objectives
To assess the incidence and degree of malrotation of tibia after fixation with intramedullary nail for tibial shaft fractures and its measurement by computed tomography (CT). The study also aims to assess the value of CT-based torsion angle in such cases.

Material and Methods
In this prospective study, fifty patients with closed/open fracture of tibia shaft (proximal 1/3, middle 1/3 or distal 1/3) with or without fracture of fibula were chosen and operated with closed/open reduction internal fixation with reamed intramedullary locked nail. Torsion angle calculated by post-operative CT and revision done for selected cases when tibial malrotation was more than 10 degrees than the control (normal side).

Results
The range of malreduction was from 43 degrees of external rotation to 12 degrees internal rotation. 15 of the 50 (30%) tibia operated showed malrotation and 5 (10%) were above 20 degrees. The repetition of torsion angle showed a variation of 3.2 to 4.3 degrees. Some injury patterns showed more malrotation than the others.

Conclusion
Assessment of tibial malrotation following intramedullary nailing has shown higher incidence of malalignment than previously reported in the literature. CT-based torsion angle calculation can be used as a reliable indicator of malrotation.