bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower abdominal cyst complicated with infection following INFIX internal fixation for pelvic fracture: A report of 2 rare cases
Authors: Yin Yijie , Jiang Jiabao , Kenmegne Guy Romeo , Fang Yue 
Published: July 2023

Abstract
Background:The Internal Fixator (INFIX) is a popular method for treating anterior pelvic ring fractures, known for its minimal invasiveness, and short operation time. However, studies have shown that postoperative complications may occur, including anterolateral femoral cutaneous nerve injury, the femoral nerve paralysis, and delayed fracture healing. These complications are believed to be related to surgical stimulation, an excessively long lateral end of the connecting rod, a small distance between the screw and bone surface, insufficient pre-bending of the connecting rod, and difficulties in fracture reduction.
Case Presentation:We report two unique cases of lower abdominal pseudocyst complicated with infection after INFIX treatment of pelvic fractures at our trauma center.Following surgical removal of the internal fixation, resolution of the cysts was observed in both patients, and subsequent postoperative follow-up revealed the absence of any residual sequelae.These cases have not been reported in previous literature reviews.
Discussion: The lower abdominal cysts, potentially arising from the dead space created during intraoperative placement of the INFIX rod, which may increase infection risk. The etiology remains uncertain, despite the presence of abnormal inflammation markers in both cases, and staphylococcus aureus found in one. These cysts were confined to the lower abdomen, not involving the internal fixation, and hence, only the INFIX was removed. Postoperative oral cefazolin treatment was successful, with resolved pseudocysts and no subsequent discomfort.
Conclusion:We report two unprecedented cases of post-INFIX abdominal cysts, with a suspected link to intraoperative dead space. Despite uncertain etiology, successful management involved INFIX removal and oral cefazolin therapy. These findings necessitate further exploration into the causes and management of such complications.
Is the OCT a predictive tool to assess visual impairment in optic chiasm compressing syndrome? A prospective longitudinal study
Authors: BOZZI Maria Teresa , MALLEREAU Charles-Henry , TODESCHI Julien , BALOGLU Seyyid , ARDELLIER François-Daniel , ROMANN Julia , TROUVE Léa , BOCSKSEI Zsolt , ALCAZAR Joffrey , DANNHOFF Guillaume , BAHOUGNE Thibault , GOICHOT Bernard , CHIBBARO Salvatore , Cebula Helene 
Published: July 2023

Abstract
Background: Visual dysfunction is a prevalent symptom in patients with non-functioning pituitary macroadenoma (NFPM); the role of OCT is such patients has not been yet determined.
Method: This is a prospective longitudinal observational study over a period of 6 years, on 20 patients presenting a radiological compression of the optic chiasma without visual acuity (VA) and visual field (VF) disturbances. The primary endpoint was to evaluate the impact of NFPA on neuro-axonal loss by measuring RNFL thickness using OCT at inclusion (T0), 12 months (T1), 24 months (T2), and 36 months (T3) respectively. The secondary endpoint was to monitor the evolution of OCT over time and assess any relationship between the degree of OCT alteration and the degree of radiological and clinical optic chiasm compression syndrome.
Results: Among the 20 patients included eight (40%) showed an altered RNFL-OCT at diagnosis, while the remaining 12 (60%) showed a normal pattern. During a mean ophthalmologic follow-up of 60 months, 4 patients (20%) presented an asymptomatic reduction of RNFL-OCT thickness although all 20 had a VA/VF stable.
Conclusion: To our knowledge, this study represents the first attempt to longitudinally evaluate the natural history and evolution of RNFL-OCT in patients with radiologically asymptomatic chiasmatic compression syndrome. The results do not clearly demonstrate a role of the OCT as early prognostic factor for visual dysfunction.
A newly discovered Lnc-PDZD7-3 increased metastatic and proliferative potential of lung adenocarcinoma cells via modulating FN1/fibronectin signaling
Authors: Zhang Guodong , Han Lu , Li Zhaoshui , Wang Yushuo , Ma Ying , Ke Xiaoming , Wang Zhendan 
Published: July 2023

Abstract
The global burden of lung adenocarcinoma (LUAD) has been on the rise, making it among the leading contributor to cancer-related deaths. Long non-coding RNA (lncRNA) are implicated in the initiation and progression of LUAD. To date, the mechanism by which lncRNA participate in LUAD are not clearly characterized. Here, we investigated the role of the newly-discovered Lnc-PDZD7-3 in the development of LUAD. Results revealed downregulation of Lnc-PDZD7-3 in human normal lung tissues and upregulation in LUAD tissues from the TCGA (The Cancer Genome Atlas) databases. Excessive expression of Lnc-PDZD7-3 promotes occurrence of distant metastasis. Lnc-PDZD7-3 knockdown suppressed the proliferative and viability potential of cells, as well enhanced apoptosis and inhibited the migratory activity of LUAD cells. Notably, expression levels of MMP9, Vimentin, Twis, Fibronectin, and MMP2 in LUAD cells were downregulated markedly except for snail following Lnc-PDZD7-3 lockdown. Through rescue experiments, we confirmed that Lnc-PDZD7-3 enhanced LUAD development by activating FN1/fibronectin signaling. Meanwhile, we also identified that Lnc-PDZD7-3 was localized in cytoplasm and nucleus segments of LUAD cells by FISH technology. In summary, this study implicates Lnc-PDZD7-3 in the pathomechanisms of LUAD via the FN1/fibronectin signaling, suggesting it may be diagnostic biomarker and therapeutic targets of LUAD.
Risk factors and clinical outcomes of immune checkpoint inhibitor-related pneumonitis in patients with advanced non-small cell lung cancer：A single center experience
Authors: Wang Ning , Xiao Renzhe , Liu Yulin 
Published: July 2023

Abstract
Purpose
Immune checkpoint inhibitors (ICIs) can lead to pneumonitis, a potentially fatal complication. Identifying patients at risk of immune checkpoint inhibitor-related pneumonitis (CIP) prior to starting ICIs treatment is essential for managing CIP. We conducted this study with the purpose of determining the prognosis and risk factors for CIP.
Methods
In this study, 360 patients with non-small cell lung cancer (NSCLC) who underwent anti-programmed cell death-1/-ligand 1 (PD-1/PD-L1) inhibitors for at least one dose from 2019 to 2022 at Hubei Cancer Hospital were included. Risk factors correlated with CIP and mortality were assessed by regression analyses. Kaplan-Meier estimates were applied to examine survival times.
Results
There were 360 patients enrolled, the incidence of CIP was 8.6% (31/360). Of all CIP, 12 were graded 3 or higher based on the Common Terminology Criteria for Adverse Events (CTCAE 5.0). The median time to CIP onset was 90 (interquartile range [IQR], 37–160) days. A significant association for CIP was found with body mass index (BMI) (p=0.004) and chronic obstructive pulmonary disease (COPD) (p=0.003) on univariate and multivariate logistic regression analyses. In patients who developed CIP and those who did not, the progression free survival and overall survival were not statistically different. Additionally, early-onset CIP had a higher risk of mortality (p=0.039, HR=3.677, 95% CI, 1.071-12.554), after adjusting for sex, age and rechallenge.
Conclusion
Increased BMI and COPD were strongly associated with CIP. Early-onset CIP significantly increased the risk of mortality.
Can childhood white coat hypertension affect left ventricular mass?
Authors: hacihamdioglu duygu ovunc , Koçak Gülendam , Kılıç Deniz , Cihan Deniz 
Published: July 2023

Abstract
Background
The aim of this study is to investigate whether children with white coat hypertension (WCH) have evidence of left ventricular geometrical changes.
Methods
A total of 237 (161 male) patients and 122 (83 male) controls with a mean age of 12.69±3.34 years were included in the study. Patients were divided into two main groups as normal weight (n=191) and obese (n=168) based on body mass index (BMI). Each group were further divided into three groups based on their blood pressure profile as hypertension (HT), WCH and control. All participant has been performed echocardiography, WCH and HT groups has been also performed ambulatory blood pressure monitoring (ABPM) and biochemical analysis. Cardiac geometry was categorized as Concentric Left Ventricular Hypertrophy [cLVH; increased left ventricular mass index (LVMI) and increased relative wall thickness (RWT)], Eccentric LVH (eLVH; increased LVMI and normal RWT), Concentric Geometry (CG; normal LVMI and increased RWT)
Results
In the present study, LV geometrical changes were observed as 36.2%, 22%, and 15% in the obese groups [HT/Obese (n=94), WCH/Obese (n=41), and Control/Obese (n=33), respectively, p=0.04]. However, it was 26.3%, 11.1%, and 1% in the non-obese groups [HT/Non-Obese (n=57), WCH/Non-Obese (n=45), and Control/Non-Obese (n=89), respectively, p=0.000] (Linear-by-linear association for obese 0.027 and for non-obese 0.000).
Conclusion
WCH can be another risk factor for cardiovascular disease. WCH can cause LV geometric changes and can be considered a pre-hypertensive intermediate state. The target-organ damage can manifest in WCH patients, especially those who are obese, or who have non-dipping BP patterns or family history
Pharmacological and surgical experimental animal models of induction of spermatogenesis disorders
Authors: Epifanova M. V. , Kostin A. A. , Malinina O. Yu. , Artemenko S. A. , Epifanov A. A. 
Published: July 2023

Introduction.Experimental induction of spermatogenesis disorders is possible mainly by physical, pharmacological methods. However, not all methods can cause non-obstructive azoospermia.Objective.To evaluate and compare the effectiveness of induction of spermatogenesis disorders in rat models by applying ligatures to the spermatic cords and administration of cisplatin.Materials & methods. Seventy-three mature male rats (Wistar) were divided into 2 experimental groups and 1 control (n = 9) group: group 1 (n = 27) with ligature on the spermatic cord for 12 h (n = 9), 24 h (n = 9), 36 h (n = 9); group 2 (n = 37) with five-fold intraperitoneal administration of cisplatin at concentrations of 5 mg/kg, 3 mg/kg, 1 mg/kg. On days 0, 7, 14, 28 after the last day of induction of spermatogenesis disorders, epididymal semen analysis, blood test, total serum testosterone, pathomorphological examination of testes tissue, body weight, reproductive system organ weight were performed to assess model performance.Results.Ligation to the spermatic cords did not have a negative effect on the general condition of the animals (p < 0.05), blood test (p < 0.05); there was a decrease in the testicular weight (p < 0.05), the appendage of the testis (p < 0.05), prostate (p < 0.05), the weight of the seminal vesicles did not change (p > 0.05). In group 1, the number of epidermal spermatozoa decreased in all subgroups, statistically significant changes were recorded at 7 (exposure 24 h) and 28 (exposure 12, 36 h) days of research. Histologically, there was no significant inhibition of spermatogenesis, except for a decrease in the area, diameter of the seminal tubules on 7, 28 days after surgery (exposure 24, 36 h). In group 2, the survival of animals was noted only when using cisplatin at a dose of 1 mg/kg five times. Body weight decreased in all rats without recovery, thrombocytopenia recorded after 1 wk, leukocytopenia regressed by 2 wk of the study. A decrease in the weight of all reproductive organs was noted. Sperm concentration decreased at 1 wk and recovered at 28 wk. In the analysis of testicular biopsies: pronounced disorganization of the spermatogenic epithelium, a decrease in the absolute area and diameter of the seminal tubules.Conclusion.Ligation to the spermatic cord does not cause permanent inhibition of spermatogenesis. Cisplatin at a dose of 1 mg/kg causes persistent severe damage to the spermatogenic epithelium.
Robot-assisted radical cystectomy with intracorporeal heterotopic neocystis: a single-centre experience of complications
Authors: Pavlov V. N. , Urmantsev M. F. , Bakeev M. R. 
Published: July 2023

Introduction. Bladder cancer (BCa) ranks 10th among all diagnosed malignant tumours. To date, radical cystectomy (RCE) with pelvic lymphadenectomy is the gold standard for the treatment of aggressive forms of BCa. The development of minimally invasive technologies has contributed to the active introduction of robot-assisted interventions into surgical practise. RCE is a modern and relevant method for treating muscle-invasive BCa and high-risk non-muscle-invasive BCa. Over the past decade, many works have been accumulated that demonstrate the success of robot-assisted RCE with intracorporeal neocystis.Objective. To analyse the complications classified according to Clavien-Dindo after robot-assisted radical cystectomies with intracorporeal heterotopic neocystis based on a single centre.Materials & methods. From 2021 to 2022, a retrospective study was conducted based on Bashkir State Medical University Clinics aimed at studying complications after robot-assisted RCEs. The group investigated consisted of 200 male and female patients with an established diagnosis of BCa. All patients were shown surgical treatment in volume of RCE by Bricker with pelvic lymphadenectomy. Surgical intervention was performed using the DaVinci ® Si robot-assisted system. After 30 and 90 days, the complications that occurred and the ways to correct them were evaluated.Results. Only 35 patients (17.5%) had 30-day complications, which were grade I-III. Fourteen (7%) patients had 90-day complications having II and III degrees. Patients with grade III or II and III complications occurred during the first 30 days after surgical treatment subsequently had 90-day complications (p < 0.05). There were no statistically significant differences between the types of 30-day complications of II and III degree and the subsequent 90-day complications (p < 0.05).Conclusion. Robot-assisted RCE is an effective and technologically advanced method of treating patients with aggressive forms of BCa. Our study demonstrates low rates of surgical complications after this surgical intervention.
Prevalence of HIV-1 drug resistance among early diagnosed HIV-infected children enrolled through the national program for prevention of mother-to-child transmission in Southern and Central Highland provinces — Vietnam within 2017–2021
Authors: Huynh H.K.T. , Valutite D. E. , Schemelev A. N. , Davydenko V. S. , Ostankova Yu. V. , Truong T.X.L. , Tran T. , Nguyen T. V. , Semenov A. V. 
Published: July 2023

Background. In Vietnam, there has been an increase in efforts to monitor and prevent mother-to-child transmission of HIV since 2013. However, data on HIV drug resistance among HIV-1 infected children younger than 18 months of age remain limited. The study fills a critical knowledge gap by providing important insights into the prevalence of resistance among this population in the Southern and Central Highland provinces of Vietnam.Objective. This study aimed to determine the prevalence of HIV drug resistance and patterns of mutation among treatment-naïve children under the age of 18 months who had been recently diagnosed with HIV.Material and methods. Between May 2017 and May 2021, stored remnant DBS samples were collected from children under the age of 18 months who had been diagnosed with HIV through routine Early Infant Diagnosis testing in Central Highland and Southern Vietnam. HIV drug resistance tests were performed, and interpretation was done using the Stanford algorithm.Results and discussion. Overall, 111 samples with eligible viremia for sequencing (ct value <31) were collected for genotyping, in which 110 protease sequences and 106 complete reverse transcriptase regions were generated. Males were 61.3%, 52.3% were aged from 6 weeks to <9 months and 37.0% were breastfed. Access to mother-to-child intervention was reported in 60.3%. The accumulation of major drug resistance mutations was found in 43.8% of infants and most of them were resistant to Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI) (37.7%). High-level resistance to Nevirapine was present in 40% of cases. The risk factors associated with NNRTI resistance were antiretroviral prophylaxis (aOR: 3.68, 95% CI: 1.83–7.45) and breast-feeding history (aOR: 2.16, 95% CI: 1.03–4.53). CRF01-AE was the predominant subtype.Conclusion. The study identified a high prevalence of resistance to NNRTIs among HIV-1 infected infants less than 18 months of age in the Southern and Central Highland provinces of Vietnam. This highlights the need for further investigation and a potentially larger national survey to confirm the extent of this issue in Vietnam. Our findings support the current actions of the Vietnam Ministry of Health, which prioritize integrase inhibitor-based regimens as the preferred first line of ART for children to achieve durable viral suppression and minimize treatment failure. This approach aligns with the recommendations of the World Health Organization.
The Concept of Tolerance in the Qur'an as A Basis for Strengthening Islamic Education
Authors: Mukaromah Lailatul 
Published: July 2023

This study aims to determine the values of tolerance in the Qur'an as a reinforcement for the world of education. The method used in the research is library research by collecting data from literature and information sources, be it books, journals, e-books, articles, theses, internet and other literature sources related to related research. Tolerance is an attitude of mutual respect and appreciation and does not restrict the freedom of others to do something. This is evidenced in Surah al Baqarah verse 256 and Surah Ar Rum verse 22 which contain the value of tolerance, namely freedom of religion and respect for differences. The form of strengthening the verse's education is freedom of thought, respect and respect for differences even though they have the same potential.
Academic Dishonesty in Online Accounting Assessments—Evidence on the Use of Academic Resource Sites
Authors: Conaway Jenelle K. , Wiesen Taylor 
Published: July 2023

ABSTRACT
As accounting programs increase their online offerings, understanding the challenges of maintaining academic integrity online is crucial. This study documents an emerging method of online academic dishonesty—on-demand services from academic resource sites (ARS) such as Chegg.com. ARS are web-based repositories of textbook problems, homework solutions, etc., and many of them employ subject-matter experts to answer questions in real time, potentially during active exams. In periods of fewer online exam safeguards, 13–25 percent of intermediate accounting students are identified as using Chegg during exams. Corroborating evidence shows an anomalous improvement in student performance in online exams with minimal safeguards, which is attenuated by an increase in mitigation policies. Survey responses confirm that students are familiar with and use ARS, including 10 percent who acknowledge use during quizzes or exams. These findings help formulate suggestions about practices educators can employ to decrease pervasive use of ARS in online learning.
JEL Classifications: M49.
PENERAPAN PENDEKATAN TPACK UNTUK MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR PESERTA DIDIK KELAS III SD NEGERI 1 KEMIRI
Authors: Nusa Putri Dian , Sumarno Sumarno , Aziz Alimuddin 
Published: July 2023

Abstract : The purpose of this study was to describe the increase in activity and learning outcomes in third grade students of SD Negeri 1 Kemiri in online learning of Theme 8 Praja Muda Karana.The researcher applies the Technological, Pedagogical, and Content Knowledge (TPACK) approach to realize these two things. The subjects of this study were 15 third grade students of SD Negeri 1 Kemiri consisting of six boys and nine girls. This research data collection technique was carried out systematically by using observation sheets of learning activities and online-based evaluation tests. Based on learning observations in three learning cycles, the results in the third cycle showed that the TPACK approach was able to increase students' learning activities by 80% and the average cognitive learning outcomes reached 85.33 or 86.67% of the number of third grade students. With the findings and observations from the first cycle to the third cycle, there was a dominant increase and reached the success indicators set by the researcher. On this basis, the researcher concludes that by applying the TPACK approach in class III, it can increase students' activities and learning outcomes. Keywords: activity, learning outcomes, TPACK Abstrak : Tujuan penelitian ini adalah untuk mendeskripsikan peningkatan aktivitas dan hasil belajar pada peserta didik kelas III SD Negeri 1 Kemiri pada pembelajaran daring Tema 8 Praja Muda Karana. Peneliti menerapkan pendekatan Technological, Pedagogical, and Content Knowledge (TPACK) untuk mewujudkan kedua hal tersebut. Subjek dari penelitian ini adalah 15 peserta didik kelas III SD Negeri 1 Kemiri yang terdiri dari enam laki-laki dan sembilan perempuan. Teknik pengumpulan data penelitian ini dilaksanakan secara sistematis dengan manggunakan lembar pengamatan aktivitas belajar dan tes evaluasi berbasis online. Berdasarkan pengamatan pembelajaran pada tiga siklus pembelajaran, hasil pada siklus ketiga menunjukkan bahwa melalui pendekatan TPACK mampu meningkatkan aktivitas belajar peserta didik sebesar 80% dan rata-rata hasil belajar kognitif mencapai 85,33 atau sebesar 86,67% dari jumlah peserta didik kelas III. Dengan temuan dan hasil pengamatan dari siklus pertama sampai siklus ketiga terjadi kenaikan yang dominan dan mencapai Indikator keberhasilan yang ditetapkan peneliti. Atas dasar tersebut, peneliti menarik simpulan bahwa dengan penerapan pendekatan TPACK pada kelas III dapat meningkatkan aktivitas dan hasil belajar peserta didik. Kata kunci : aktivitas, hasil belajar, TPACK