bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural dynamics in the rodent motor cortex enables flexible control of vocal timing
Authors: Banerjee Arkarup , Chen Feng , Druckmann Shaul , Long Michael A. 
Published: January 2023

ABSTRACTNeocortical activity is thought to mediate voluntary control over vocal production, but the underlying neural mechanisms remain unclear. In a highly vocal rodent, the Al-ston’s singing mouse, we investigate neural dynamics in the orofacial motor cortex (OMC), a structure critical for vocal behavior. We first describe neural activity that is modulated by component notes (approx. 100 ms), likely representing sensory feed-back. At longer timescales, however, OMC neurons exhibit diverse and often persistent premotor firing patterns that stretch or compress with song duration (approx. 10 s). Using computational modeling, we demonstrate that such temporal scaling, acting via downstream motor production circuits, can enable vocal flexibility. These results provide a framework for studying hierarchical control circuits, a common design principle across many natural and artificial systems.
Network structure influences the strength of learned neural representations
Authors: Kahn Ari E. , Szymula Karol , Loman Sophie , Haggerty Edda B. , Nyema Nathaniel , Aguirre Geoffrey K. , Bassett Dani S. 
Published: January 2023

AbstractHuman experience is built upon sequences of discrete events. From those sequences, humans build impressively accurate models of their world. This process has been referred to as graph learning, a form of structure learning in which the mental model encodes the graph of event-to-event transition probabilities [1], [2], typically in medial temporal cortex [3]–[6]. Recent evidence suggests that some network structures are easier to learn than others [7]–[9], but the neural properties of this effect remain unknown. Here we use fMRI to show that the network structure of a temporal sequence of stimuli influences the fidelity with which those stimuli are represented in the brain. Healthy adult human participants learned a set of stimulus-motor associations following one of two graph structures. The design of our experiment allowed us to separate regional sensitivity to the structural, stimulus, and motor response components of the task. As expected, whereas the motor response could be decoded from neural representations in postcentral gyrus, the shape of the stimulus could be decoded from lateral occipital cortex. The structure of the graph impacted the nature of neural representations: when the graph was modular as opposed to lattice-like, BOLD representations in visual areas better predicted trial identity in a held-out run and displayed higher intrinsic dimensionality. Our results demonstrate that even over relatively short timescales, graph structure determines the fidelity of event representations as well as the dimensionality of the space in which those representations are encoded. More broadly, our study shows that network context influences the strength of learned neural representations, motivating future work in the design, optimization, and adaptation of network contexts for distinct types of learning over different timescales.
Assessment of levamisole HCl and thymosin α1 in two mouse models of amyotrophic lateral sclerosis
Authors: Borchelt David R. , Ellison Siobhan 
Published: January 2023

AbstractAmyotrohpic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes generalized muscle weakness and atrophy. Neuropathologically, ALS is defined by severe loss of upper and lower motor neurons with a robust neuroinflammatory response. In the present study, we have examined the potential utility of two drugs that have indications as immune modulators, levamisole HCl and thymosin α1. These drugs were tested in two models models that reproduce aspects of ALS. We conducted a 14 week dosing study of these two drugs in the SOD1G93Aand Prp-TDP43A315Tmodels of ALS. The drugs were given once daily for two weeks and then every other day for 6 weeks for a total of 8 weeks of treatment. Outcome measurements included efficacy assessment on the neuromuscular phenotypes, and pathological analyses of ubiquitin load and neuro-inflammatory markers in spinal motor neurons. Neither of these drug treatments produced significant extensions in survival; however, there were changes in ubiquitin load in SOD1G93Amice that suggest the drugs could be beneficial as additions to other therapies.
Crb3 stabilizes activated Ezrin-Radixin-Moesin to organize the apical domain of multiciliated cells
Authors: Burcklé Céline , Raitière Juliette , Kodjabachian Laurent , Le Bivic André 
Published: January 2023

AbstractCell shape changes mainly rely on the remodeling of the actin cytoskeleton. Multiciliated cells (MCCs) of the mucociliary epidermis ofXenopus laevisembryos, as they mature, dramatically reshape their apical domain to grow cilia, in coordination with the underlying actin cytoskeleton. Crumbs (Crb) proteins are multifaceted transmembrane apical polarity proteins known to recruit actin linkers and promote apical membrane growth. Here, we identify the homeolog Crb3.L as an important player for apical domain morphogenesis in differentiatingXenopusMCCs. We found that Crb3.L is initially present in cytoplasmic vesicles in the vicinity of ascending centrioles/basal bodies (BBs), then at the expanding apical membrane concomitantly with BB docking, and finally in the ciliary shaft of growing and mature cilia. Using morpholino-mediated knockdown, we show that Crb3.L-depleted MCCs display a complex phenotype associating reduction in the apical surface, disorganization of the apical actin meshwork, centriole/BB migration defects, as well as abnormal ciliary tuft formation. Based on prior studies, we hypothesized that Crb3.L could regulateEzrin-RadixinMoesin (ERM) protein subcellular localization in MCCs. Strikingly, we observed that endogenous phospho-activated ERM (pERM) is recruited to the growing apical domain of inserting MCCs, in a Crb3.L-dependent manner. Our data suggest that Crb3.L recruits and/or stabilizes activated pERM at the emerging apical membrane to allow coordinated actin-dependent expansion of the apical membrane in MCCs.
Solar energy for the airport ground support equipment – a quantitative study
Authors: Yıldız Melih , Mutlu Savaş , Nagy Andras , Kale Utku 
Published: January 2023

Purpose
This paper aims to evaluate the hypothetical situation in a resembling airport to Esenboga Airport and analyzes the condition of all ground support equipment (GSE) equipment to be supplied by electricity produced by solar panels mounted on the rooftop of the terminal building. The case is discussed using environmental emissions and economic feasibility. The results of the resembling case can be generalized to all airports for the reduction of emissions caused by ground operations of aviation.

Design/methodology/approach
GSE fleet data which has been prepared by TGS operated in the Esenboğa Airport have been used to calculate emissions, and equivalent electricity consumption. A hypothetical solar panel construction on the rooftop of the terminal building and also the electricity production case was analyzed. Based on the calculations, both fuel and electricity use cases are compared by means of emissions and production costs using real data.

Findings
The electricity production and transmission pose a high value of emissions. Thus, electrification of GSE in the airport need a new approach such as producing the electric energy in the site. This research analyzes the case that the electricity is produced on the rooftop of terminal building and consumed by the GSE fleet. The authors discussed that it is both feasible and possible to electrify all the GSE except a shortage of two cold months with high fuel demand by using electric storage options.

Practical implications
Ground handling is performed by using GSE which is historically powered by diesel and such internal combustion engines which are well known for their high emission rates. As most of the airports reside in populated areas, GSE emissions need to be evaluated for reduction. However the electric energy could be an alternative for GSE emissions reduction

Originality/value
Aviation is a system of many subsystems in which the performance of each unit plays a crucial role in the final success of the system. Concerns on environmental protection make the aviation industry focus on reducing emissions produced during operations. Although aircraft emissions are widely discussed in the literature, ground handling systems which are an integral part of the whole aviation system, also need to be studied regarding the environmental issues. Besides, the European Union has set out targets of reducing emissions at the airports during ground operations to zero. This paper discusses the possibility of the target by comparing various scenarios
The moderating role of perceived trust and perceived value on online shopping behavioral intention of Palestinian millennials during COVID-19
Authors: Baidoun Samir D. , Salem Mohammed Z. 
Published: January 2023

Purpose
The paper aims to examine the moderating role of both the perceived value and perceived trust in the relationship between the ease of use, perceived risk, perceived usefulness and quality of website and the Palestinian millennials’ behavioral intention toward online shopping.

Design/methodology/approach
A survey questionnaire was carried out targeting 357 Palestinian millennials. In total, 311 valid responses were processed and analyzed using PLS-SEM model fitting approach.

Findings
The findings demonstrate that the impact of ease of use, perceived usefulness and website quality on online shopping behavioral intention are reinforced by perceived value and perceived trust, while the effect of perceived risk is weakened. This implies that improving convenience and lowering non-monetary costs such as time and effort will enhance the customers’ perceived value and, as a result, their shopping behavioral intention. In addition, one of the most significant barriers to online shopping is a lack of trust. Therefore, once trust is established, shopping willingness rises, and vice versa.

Research limitations/implications
As this study focused on consumers from a developing country, it neglected the cross-cultural issue; thus, future studies may have to make a comparison of other samples from various nations to gain a deeper understanding. Furthermore, this research focused on the ease of use, perceived risk, perceived usefulness and perceived quality of the website to predict the customer’s behavioral intention toward online shopping, which shows significant results, indicating that more research is needed to look at these independent variables as predictors of customers purchasing decision.

Practical implications
Online shopping is a critical topic that has significant impact on the business world. Investigating the moderating role of perceived trust and perceived value on Palestinian millennials’ online shopping behavioral intention during COVID-19 might give useful information for organizations developing policies and strategies to create direct sales using social media platforms. Furthermore, the findings might also be valuable for management studies and academics to better understand consumers’ intentions when it comes to commercial internet buying.

Originality/value
The empirical nature of this paper gives a thorough explanation of the phenomena of online shopping from a developing country. To the best of the authors’ knowledge, this is the first empirical study that examines the moderating effect of perceived trust and perceived value on Palestinian millennials’ online shopping behavioral intention during COVID-19.
Experiences of conflict, non-acceptance and discrimination are associated with poor mental well-being amongst LGBTQ-identified individuals in Singapore
Authors: Toh Gerard W. , Koh Wee Ling , Ho Jack , Chia Jackson , Maulod Ad , Tirtajana Irene , Yang Peter , Lee Mathia 
Published: January 2023

PurposeHealth disparities affecting lesbian, gay, bisexual, transgender and queer (LGBTQ) populations have been reported in many countries. For Singapore, no large quantitative studies on mental health and well-being in the local LGBTQ community have been published. The authors conducted a community-based survey (National LGBT Census Singapore, 2013; NLCS2013) that covered a comprehensive set of demographic, social and health indicators. Here, the authors investigated mental health status and its correlates in 2,350 LGBTQ individuals within the NLCS2013 sample.Design/methodology/approachThe NLCS2013 was an anonymous online survey conducted amongst self-identified LGBTQ adults (aged ≥ 21 years) residing in Singapore. The survey included the World Health Organisation Well-being Index (WHO-5) as a measure of mental well-being, with low WHO 5 scores (<13/25) indicating poor mental well-being. The authors analysed relationships between low WHO-5 score and a range of respondent characteristics using multivariate logistic regression.FindingsStrikingly, 40.9% of 2,350 respondents analysed had low WHO-5 scores, indicating poor mental well-being. Parental non-acceptance, experience of conflict at home and bullying/discrimination in the workplace or educational environments were all significantly associated with poor mental well-being. Conversely, community participation appeared protective for mental well-being, as respondents who participated in LGBTQ community organisations or events were less likely to have poor mental well-being than non-participants.Originality/valueThe NLCS2013 represents one of the first broad-based efforts to comprehensively and quantitatively capture the sociodemographic and health profile, including mental health status, within Singapore’s resident LGBTQ population. These findings affirm the need to address the mental health needs of LGBTQ individuals in Singapore and to foster safe spaces and allyship.
The flow and heat in the conical region of a rotating cone and an expanding disk
Authors: Turkyilmazoglu Mustafa 
Published: January 2023

Purpose
The fluid flow and heat transfer between a rotating cone above a stretching disk is the prime purpose of the current work. Making use of suitable similarity transformations, it is shown that the physical phenomenon is represented by a system of similarity equations, which is compatible with that of literature in the absence of wall expansion.

Design/methodology/approach
Numerical simulation of the system enables us to seize the physical character of fluid filling the conical section as well as of the heat transfer, from small to adequately large gap sizes. How the surface expansion will contribute to the momentum and thermal layers; moreover, to the swirl angle from the disk wall, and heat transports from the cone and disk surfaces is studied in detail.

Findings
The results are clear evidences that the wall stretching completely changes the flow and heat behaviors within the conical gap. For instance, the centripetal/centrifugal flow properties of disk/cone are completely altered and the flow swirling angles are increased by means of the wall deformation.

Originality/value
The original value is that at small gap angles faster expansion of the wall overall leads to near-disk surface cooling, while causing the heated region near the cone surface, which has physical implications in practical applications.
Impact of the COVID-19 pandemic on business-to-business relationships in digital ecosystems: an African perspective
Authors: Antai Imoh , Eze Nonyelum Lina 
Published: January 2023

PurposeIn the African context, the threat of the disruption of traditional business value-creation processes, currently facilitated by the growing information technology (IT) ecosystem, came with the coronavirus disease 2019 (COVID-19) pandemic. Thus, this paper aims to investigate the impacts of the COVID-19 pandemic on interfirm relationships within the context of the digital ecosystem in Africa.Design/methodology/approachThis study employs an explanatory–exploratory qualitative approach from an interpretivist stance to investigate the impacts of the COVID-19 pandemic on interfirm relationships. The authors conducted seven in-depth interviews with top management executives in a Nigerian technology company, together with the company's archival data that provided the pre, during and post pandemic (2018–2021) business-to-business (B2B) relationship structures, to determine how these relationships have been affected.FindingsThe results suggest that the pandemic had a minimal effect on partnership relationships in the B2B ecosystems of the case company but affected only non-partnership relationships.Research limitations/implicationsThe authors' qualitative study is interpretive and the sample size is limited. Hence, there is a need for caution in generalizing the findings. The framework can be further validated across a wider population.Practical implicationsPartnerships can help organizations weather business crises. Consequently, organizations should maintain a healthy number of partnership relations to deal with periods in which challenges emerge in the business landscape. In other words, with tight contracts and a strategic focus on goals and objectives, partnership relations can help organizations weather business crises.Originality/valueThis study builds upon the burgeoning body of literature on digital ecosystems within the African context, which is a relevant contextual contribution.
Techniques to strengthen entrepreneurship: is mindfulness a useful concept for resilience development?
Authors: Aránega Alba Yela , Castaño Sánchez Rafael , Ribeiro-Navarrete Samuel 
Published: January 2023

Purpose
The purpose of this study is to increase the resilience capacity of residential health-care professionals to achieve intrapreneurial development in workers. Through training based on the development of emotional competencies and the application of mindfulness techniques, the aim is for the individual to become aware of his or her role, learn to manage emotions and reduce feelings of distress and anxiety.

Design/methodology/approach
The proposed programme has a duration of eight weeks. Every four days of training, mindfulness sessions are integrated, and at the beginning and end of the working day, 10 min are spent with superiors to give feedback on what happened during the day and the setting of new objectives. A control group is also established where they do not undergo such training. After the delivery of the programme, the results obtained after the application of the methodology to a sample of 91 residential health-care professionals are presented. By means of a validated resilience questionnaire composed of 25 items, the aim is to measure the resilience capacity of the participants before and after training and to observe the impact of the programme.

Findings
The results of this study show that the training has led to an improvement in the overall resilience capacity by 3.93% and has been able to reduce the existing gap between those over 45 years of age and younger people, although the age-related variable still represents a significant difference.

Originality/value
This study provides an innovative way of fostering entrepreneurship. While participants work on resilience management through mindfulness techniques, organisational commitment is achieved.
Barriers to information and digital technology adoption in humanitarian supply chain management: a fuzzy AHP approach
Authors: Kabra Gaurav , Ramesh Anbanandam , Jain Vipul , Akhtar Pervaiz 
Published: January 2023

PurposeThe humanitarian supply chain (HSC) area is rich with conceptual frameworks with a focus on the importance of information and digital technology (IDT) applications. These frameworks have a limited scope in investigating and prioritizing barriers to IDT adoption in HSCs. The present study thus identifies and prioritizes the barriers to IDT adoption in organizations involved in HSCs.Design/methodology/approachBy using a literature review allied with expert discussions and a fuzzy analytic hierarchy process (F-AHP), the study identifies and prioritizes a comprehensive set of barriers that organizations involved in HSCs may consider to improve IDT adoption.FindingsThe study investigates five main barriers (strategic, organizational, technological, financial and human) interlocked with 25 sub-barriers impacting the level of IDT adoption in organizations involved in HSCs. The findings indicate that strategic barriers (SBs) are of greatest importance, followed by organizational, technological, financial and human barriers. The findings indicate the difference in ranking barriers influencing the adoption of IDTs in HSCs compared to the commercial supply chain.Research limitations/implicationsAlthough a three-step method adopted for this study is rigorous in terms of the way this research is conducted, it is essential to report that prioritization is based on the subjective opinions of the experts.Practical implicationsThe findings aim to assist policymakers and practitioners in developing effective strategies to improve IDT adoption in organizations engaged in HSCs. Moreover, the prioritization of barriers provides a systematic way to overcome any barriers to improve HSC performance.Originality/valueThis study is first of its kind that investigates and prioritizes the barriers to IDT adoption in HSCs.
A systematic literature review of food banks’ supply chain operations with a focus on optimization models
Authors: Rivera Adrian Fernando , Smith Neale R. , Ruiz Angel 
Published: January 2023

Purpose
Food banks play an increasingly important role in society by mitigating hunger and helping needy people; however, research aimed at improving food bank operations is limited.

Design/methodology/approach
This systematic review used Web of Science and Scopus as search engines, which are extensive databases in Operations Research and Management Science. Ninety-five articles regarding food bank operations were deeply analyzed to contribute to this literature review.

Findings
Through a systematic literature review, this paper identifies the challenges faced by food banks from an operations management perspective and positions the scientific contributions proposed to address these challenges.

Originality/value
This study makes three main contributions to the current literature. First, this study provides new researchers with an overview of the key features of food bank operations. Second, this study identifies and classifies the proposed optimization models to support food bank managers with decision-making. Finally, this study discusses the challenges of food bank operations and proposes promising future research avenues.