bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating network pharmacology and molecular docking for the identification of key genes and therapeutic targets of Nigella sativa in multiple sclerosis treatment
Authors: Kapadia Hardi , Vora Divya , S. Manjegowda Dinesh , Nair Ajay , Sharma Sameer , Dinesh Susha 
Published: July 2023

Introduction and Aim: Multiple sclerosis (MS) is a chronic neurodegenerative disease affecting around 2.8 million people worldwide. MS pathophysiology is not yet explained up to the mark, which is the cause of difficulty and complexity in treating the illness. Most present-day scenarios are engrossed in inhibiting central nervous system (CNS) inflammation. However, this is not enough, hence the present study aims at finding best neuroprotective treatment without adverse effects.

Materials and Methods: In silico attempt to validate the phytocompounds from Nigella sativa and showcase their use for targeting the neuroprotective mechanism involved in management of MS by finding the key potential genes which were derived from mRNA datasets of previous research. Various bioinformatics tools and software such as GEO, String, ShinyGO, PyRx were used to carry out the current study. The leading steps involve retrieval of targets from mRNA datasets, molecular docking of phytocompounds with the targets and pharmacological analysis.

Results: These phytocompounds from seeds of N. sativa showed promising results as therapeutic agents against target genes RPL27, RPS14 and FAU for management of MS during current in silico study, but any treatment prior its clinical practice should validate with large robust data, which lies as the future prospective here.

Conclusion: In summary notable progress in management of MS with better understanding of pathology has been made and many disease modifying therapies (DMT) are made available but the question of safety and efficacy is still challenging due to adverse effects associated with these therapies. Hence properties of N. sativa must be explored as a therapeutic agent that can reduce the neuronal degeneration.
Meios de fixação mais utilizados em fraturas de ângulo mandibular
Authors: Franck Felipe Calile , Oliveira Junior Paulo Afonso de , Vitale Marcelo , Pino Danilo Siqueira , Dias Francisco José de Nadai 
Published: July 2023

A mandíbula, apesar de ser um osso resistente e pesado, está sujeita a fraturas por se localizar na região inferior da face. Em casos de acidentes de trânsito, pela brusca força gerada na movimentação da cabeça, a mandíbula absorve esta força e a projeta na face. Embora 40% de todas as fraturas de face sejam na mandíbula, sendo 21% delas na região de ângulo mandibular, o tratamento ideal para este tipo de fratura ainda é controverso. Exis-tem duas filosofias diferentes que os cirurgiões se fundamentam para a escolha da técnica a ser realizada no tratamento de fratura na região de ângulo mandibular (FAM): o primeiro grupo segue os mandamentos da AO/ASIF (Arbeitsgemeinschaft für Osteosynthesefra-gen), que acredita que os fragmentos da fratura devem ser totalmente imobilizados, ou seja, deve-se utilizar um método rígido; já o segundo grupo acredita nos fundamentos da técnica desenvolvida por Champy, em que o meio de fixação deve ser semirrígido, sem a ne-cessidade de imobilização absoluta dos cotos da fratura. Estudos recentes apontam que o uso de miniplacas proporcionam estabilidade relativa, ou seja, não há imo-bilização absoluta. A técnica tornou-se popular entre os cirurgiões por se mostrar segura, eficaz e menos invasiva, quando bem indicada. É possível concluir que não há necessidade de o cirurgião sempre optar por um único meio de fixação nos casos de fratura em ângulo mandibular. O melhor meio de fixação neste tipo de fratura deve ser escolhido de acordo com cada caso clínico, podendo ser rígido ou semirrígido, com acesso intraoral ou extraoral. O presente trabalho objetiva reali-zar um levantamento bibliográfico a respeito dos meios de fixação mais utilizados por cirurgiões especialistas no tratamento de fratura no ângulo mandibular em traumas de face, elegendo a técnica ideal para cada caso.
Translation of Cultural Words in Folk Tale “The Origin of the Word Babah” on the Google Translate Service
Authors: Siddiq Mohammad , Nur Ali Ahmad Juma Khatib 
Published: July 2023

Background: Folk tale contains words that are bound to a certain cultural context. Globalization and technological developments have made wider access to the folk tales. Google Translate is a translation service that can help translate folk tales with a wide range of users.
Purpose: The focus of this research is limited to how the Google Translate service translates the cultural words in the folk tale of The Origin of the Word Babah.
Design and methods: This research method is descriptive qualitative with research data on the cultural words in the folk tale The Origins of the word Babah which is published by the Ministry of Education and Culture in 1978. This study used analysis of translation strategies and Newmark’s Cultural Words categories as referred classification.
Results: The result of the study shows that the 10 (ten) research data are all in the category of social customs. The translation strategies used are Loan with 5 (five) data and Literal Translation with 5 (five) data. This research shows that Google Translate has not been able to detect cultural contexts, hence it is not accurate in translating cultural addresses and special terms.
Afrika Zamani: n°26, 2018 - Full Issue
Authors: Journal System  
Published: July 2023

Contents
Conscientious Achievements of the Dangme before the Atlantic Contact: Insights from Archaeological and Ethnohistorical Investigations at Sega and Kpone, Greater Accra Region, Ghana
Fritz Biveridge .......................................................... 1
Quand la reine-mère Dokuwa libère l’Akyem Abuakwa de ladomination Ashanti
Kouamé René Allou .......................................................................25
Recruitment, Resistance and Memories of the First World War among the Terik of Kenya
Eliud Biegon .................................................................................33
Parcours de la première génération de leaders politiques en Casamance : affirmation identitaire et luttes politiques au Fuladu (1946-1958)
Mouhamadou Moustapha Sow .................................................................................59
Youth Activism and Ethnic Violence in Nigeria: From Decolonisation to the Nigeria-Biafra War
Gloria Chuku ..............................................................................................77
Operation Vijiji and its Aftermath: Land Nationalisation, Villagisation and Disputes in Mbulu District, North-Western Tanzania, 1961–2006
Juma Marmo Paresso .............................................................................109
Le minbar de la dispute ou l’affaire de la « grande mosquée » de Bakel (1995-1996)
Saliou dit Baba Diallo ........................................................................................ 133
Strategi Pemasaran Untuk Meningkatkan Pejualan Produk Pada PT. Cipta Niaga Semesta Palembang
Authors: Rusdianto Rusdianto , Subiyanto Subiyanto 
Published: July 2023

Tujuan penelitian ini adalah untuk mengetahui bagaimana strategi pemasaran pada PT. Cipta Niaga semesta Palembang dengan menggunakan bauran pemasaran atau marketing mix. Data yang digunakan adalah data sekunder dari tahun 2016-2020, hasil penelitian ditemukan beberapa strategi pemasaran di PT. Cipta Niaga semesta Palembang yaitu strategi pemasaran dibidang promosi. Pelaksanaan periklanan yaitu menggunakan iklan di televisi, youtube, dan bagi-bagi brosur, pelaksanaan personal selling yaitu dengan cara menawarkan produk ke pasar-pasar tradisional, toko-toko, dan outlet-outlet, pelaksanaan promosi penjualan yaitu dengan cara SPG/B menjual ke warung kecil, warung kopi dan masyarakat setempat serta membawa hadiah, pelaksanaan publikasi yakni menjadi sponsor dalam acara-acara tertentu dan pelaksanaan hubungan masyarakat yakni dengan cara melakukan sampling. Strategi promosi yang dilakukan PT Cipta Niaga semesta Palembang sudah lumayan efektif yakni menerapkan strategi personal selling, periklanan, publisitas, hubungan masyarakat, dan juga promosi penjualan. Hanya saja tidak semua strategi promosi berjalan dengan lancar seperti personal selling, dan promosi penjualan. Hal-hal tersebut berdampak langsung terhadap penjualan. Untuk itu penulis memberi saran perusahaan harus lebih memperhatikan alat untuk meningkatkan penjualan maka pelaksanaan personal selling sebaiknya para tenaga kerja atau sales diberi training atau latihan khusus yang terprogram, dan pada pelaksanaan promosi penjualan perusahaan hendaknya mulai mencari cara-cara baru yang lebih mudah dan efektif dalam membujuk calon pelanggan serta ditingkatkan dan diperpanjang lagi masa periode pemberian hadiah.
Review: Pengembangan Branding Bangkalan Sebagai Kota dengan Kultur Islami yang “Sustainable”
Authors: Wicaksono Dian , Dianfitria Mira , Pradana Andang 
Published: July 2023

Munculnya pandemi COVID-19 di awal tahun 2020 telah memberikan tantangan berat bagi Kabupaten Bangkalan dalam mengakselerasi pertumbuhan perekonomian. Dalam menghadapi momentum- momentum pada tahun 2020 – 2030, maka Kabupaten Bangkalan membutuhkan Strategic Roadmap 2030 sebagai acuan arah pembangunan dan memperkuat persepsi stakeholder terhadap brand Kabupaten Bangkalan. Tahapan pembangunan tersebut yaitu (1) Mengembangkan Pariwisata Halal yang terintegrasi dengan memanfaatkan Entrepreneurial Mindset, (2) Pengembangan Ekosistem Industri Halal Untuk Pengembangan Ekonomi, (3) Mewujudkan Kota Islam yang Berkelanjutan. Pada fase pembangunan pertama mengusung tema target pembangunan yaitu “Integrated Halal Tourism with Entrepreneurial Spirit”. Fase pertama ini merupakan fase pemulihan (recovery) perekonomian akibat situasi pandemi. Pengembangan potensi wisata dapat menjadi alternatif terbaik untuk menjadi quick win pengembangan Kabupaten Bangkalan dengan memanfaatkan sumber daya lokal yang sudah tersedia melalui berbagai kolaborasi. Pada konsep Halal Entrepreneurial Mindset, pariwisata halal yang terintegrasi di Kabupaten Bangkalan dapat dibangun melalui 3 kunci utama: (1) Memanfaatkan peluang dalam menarik wisatawan, (2) Berani mengambil risiko untuk mengembangkan produk pariwisata, dan (3) Kolaborasi dalam meningkatkan brand pariwisata Bangkalan.
Relevance and Responsiveness of the Bachelor of Science in Customs Administration Program as Assessed by Stakeholders
Authors: Balajadia Ruth 
Published: July 2023

Responsiveness/relevance is perceived as the starting point for determining what constitutes a quality education. Since development is necessary, systems that support development, like education and training systems, must be responsive. This study is focused on the relevance and responsiveness of the Bachelor of Science in Customs Administration (BSCA) program and to determine whether the initiatives currently practiced by the college to make the program relevant/responsive are effective. John B. Lacson Colleges Foundation-Bacolod is a higher education institution that offers a BSCA program and is the only one in Negros Occidental. However, despite the very satisfactory results in the board examination in the past years and the high demand for employment in the import and export industry, only a few are enrolled in the program. Hence, the conduct of this study is to explore opportunities to improve enrolment. This descriptive study used the survey method to gather the data needed, with Mean and Standard Deviation as statistical tools. A discussion with representative stakeholders was made on the initiatives and strategies practiced by the college to calibrate the program. The respondents were 24 BSCA students, 53 alumni, and 22 industry representatives. The findings showed that the BSCA program is relevant and responsive to a very great extent, as assessed by the alumni and students, and relevant/responsive to a great extent by the industry.
Characteristics and clinical features of cauda equina syndrome: insights from a study on 256 patients
Authors: Zeb Junaid , Zaib Jehan , Khan Arshad , Farid Mehreen , Ambreen Seemab , Shah Syed Hussaini 
Published: July 2023

Objective: To determine the frequency, clinical presentation, and etiological factors of cauda equina syndrome (CES). Materials and method: This retrospective study was done on 256 participants, and aimed to analyze the frequency and patterns of clinical presentation in suspected cases of CES. The inclusion criteria included participants aged 18 or older with medical records available for review and having red-flagged symptoms for CES. The study collected information on various factors such as age, gender, confirmation of CES on MRI, neurological deficits, etiological factors, duration of symptoms, and more. The data collected was analyzed using descriptive statistics and logistic regression to identify significant variables between MRI-proven CES and suspected CES. Results: The mean age was 58.05 ± 19.26 years, with 151 females (58.98%) and 105 males (41.02%). The majority (50.78%) had a neurological deficit, while other symptoms included difficulty initiating micturition or impaired sensation of urinary flow (17.58%), loss of sensation of rectal fullness (3.12%), urinary or faecal incontinence (35.16%), bilateral sciatica (21.88%), neurological symptoms in the lower limbs (25.00%), anaesthesia or any leg weakness (24.22%), and bilateral sciatica as the predominant symptom (21.88%). Symptoms were chronic in 47.27% and acute in 21.88%. The odds of MRI-proven CES increase by 3% per year of age. Neurological deficit was strongly associated with MRI-proven CES (OR = 14.97), while loss of sensation of rectal fullness increased the odds by 10-fold (OR = 10.62). Conclusion: CES can present with various symptoms, including the bilateral neurological deficit, urinary and faecal incontinence, and bilateral sciatica, with age, severe bilateral neurological deficit, and loss of sensation of rectal fullness being associated with MRI-proven CES. Early diagnosis and treatment are crucial for better outcomes.
The Effectiveness of Roselle Kombucha Tea in Increasing Haemoglobin Levels Mice (Mus imusculus) With Anaemic
Authors: Wijayanti Tut Rayani Aksohini , Retnaningsih Reny 
Published: July 2023

Anaemic caused by Iron deficiency can be affected by a lack of vitamin C. Vitamin C can reduce ferrous iron (Fe3+) to ferrous (Fe2+) in the small intestine so that it is easily absorbed. Kombucha tea is a functional drink known to the public for a long time and provides health benefits. The study aimed to determine the effectiveness of kombucha rosella tea against increasing haemoglobin levels in mice (Mus musculus) anaemic. The type of research is true experimental with a pre-post test randomized control group design. Treatment with four treatments and three repetitions. The sample from this study was mice (Mus musculus), female, 2-3 months, weighing 20-25 as many as 24 heads. Administration of kombucha rosella tea in anaemic mice at different doses (0.36 ml / 20 g BB, 0.55 ml / 20 g BB and 0.73 ml / 20 g BB) for 14 days. Giving kombucha rosella tea can increase haemoglobin levels in the blood of mice (Mus musculus) anaemic. The optimal dose of use of kombucha rosella tea against an increase in haemoglobin levels in the blood of anaemic mice is 0.73 ml / 20 g BB. It is necessary to conduct further research on using kombucha rosella tea in human subjects to obtain further substantiation of the benefits of kombucha rosella tea as a treatment therapy.
TARIKAN SUPERMARKET TERHADAP PERGERAKAN KENDARAAN
Authors: Artana Made Agus , Ardi Juni 
Published: July 2023

Supermarket merupakan salah satu jenis pemanfaatan tata guna lahan yang akan menimbulkan tarikan pergerakan kendaraan. Untuk mengetahui model tarikan kendaraan pada supermarket data yang digunakan meliputi data jumlah pengunjung, jumlah pegawai, luas gedung, luas area parkir, dan jumlah kendaraan. Dua model hasil matematis weekday dan weekend, yaitu (Y) 5,775 + 41,225 (X3) pada weekday dengan variabel jumlah pegawai (X3) yang paling berengaruh dengan nilai R2 (R Square) sebesar 0,814 dan (Y) = 276,130 + 1,520 (X4) pada weekend dengan variabel jumlah kendaraan (X5) yang paling berengaruh dengan nilai R2 (R Square) sebesar 0, 941.
BERPIKIR KREATIF SISWA DILIHAT DARI VARIASI CARA PENYELESAIAN SOAL LUAS TRAPESIUM
Authors: Renjani Destya , Rif'at Mohamad , Suratman Dede 
Published: July 2023

Creative thinking is one of the goals of national education, which means that every student is expected to develop it, so that students are accustomed to practicing their thinking skills to create new thoughts. Therefore, in solving problems students are expected to be able to use more than one way of solving. So, this study aims to describe students' creative thinking in variety ways of solving trapezoid area problems. Where students will solve trapezoid area problems using different solutions. The research method used is descriptive qualitative. The subjects in this study were 10 students of class VIII A SMP Negeri 9 Pontianak. The results showed that the overall average percentage of students in the variety of ways of solving the trapezoid area problem was in the fairly good category (50%). In fluency aspect, there are 7 (70%) students can meet the aspect and 3 (3%) students didn’t. In flexibility aspect, there are 6 (60%) students can meet the aspect and 4 (40%) students didn’t. In originality aspect, there are 2 (20%) students can meet the aspect and 8 (80%) students didn’t. In elaboration aspect, there are 5 (50%) students can meet the aspect and 5 (50%) students didn’t. Keywords: Creative thinking, Solve Problems using Different Solutions, Variety of Solutions
KEMAMPUAN PENALARAN ADAPTIF SISWA DALAM MENYELESAIKAN SOAL KONTEKSTUAL DITINJAU DARI ADVERSITY QUOTIENT
Authors: Nurhaissyah Nurhaissyah , Yusmin Edy , Rif'at Mohammad 
Published: July 2023

This research aims to describe students' adaptive reasoning abilities in solving contextual problems on absolute value topic based on adversity quotient (AQ) of climber, camper and quitter types at SMAN 1 Teluk Keramat. The method used in this research is descriptive. Based on the results of the research. This research subjects were six students at X MIPA 2 in the 2021/2022 academic year which three subjects have AQ of climber and three subjects have AQ of camper. Based on the results of data analysis, it was found that the adaptive reasoning abilities of students who have the AQ climber type have different abilities from each other, two of the three subjects of the AQ climber type are able to answer all indicators of adaptive reasoning, and the other one is only able to answer four reasoning indicators; the adaptive reasoning ability of students who have the AQ camper type also has different abilities from each other but three subjects from the AQ Camper type are able to fulfill three of five indicators of adaptive reasoning; the adaptive reasoning ability of students who have the AQ quitter type was not found in this research.
Wariantywność końcówek rzeczownikowych w dopełniaczu liczby mnogiej w języku chorwackim
Authors: Jachimczyk Dominik 
Published: July 2023

Varation of inflectional suffixes –i and –a with movable -a- in the genitiv case in the plural in Croatian
Summary
The paper is an attempt to determine the frequency of inflectional suffix –i and –a with movable -a- in the genitiv case in the Croatian language, and to find factors detemining it. The first part presents the current state of knowledge and research on the inflectional suffixes in scientific papers and grammars. The second part carries out an analysis on the material extracted from the hrWaC corpus with regard to: the number of attestations, the word stem, the place of articulation, and an analysis of collocations. The Pernar part is an analysis of Ivan Pernar’s language with regard to data obtained in the second section.
PRODUCTIVITY OF REPAIR HEIFERS OF KALMYK CATTLE OF DIFFERENT BIRTH SEASONS
Authors: САДЫКОВ М.М. , АЛИХАНОВ М.П. , СИМОНОВ Г.А. 
Published: July 2023

В статье представлены результаты по выращиванию в предгорной зоне Дагестана телок калмыцкой породы разных сезонов рождения. Установлено, что выращивание животных по технологии мясного скотоводства позволяет повысить у них живую массу к 18-месячному возрасту. В 8 мес. телки зимнего сезона рождения (II опытная группа) превосходили сверстниц, рожденных весной (I контрольная группа) на 14,4 кг, или на 8,3% (Р≤0,01). В 12-месячном возрасте они достигали массы тела 253,4 кг, что было больше, чем у сверстниц весеннего сезона рождения, на 17,6 кг, или на 7,5% (Р≤0,01). В 18 мес телки ΙΙ группы сохраняли высокую интенсивность роста, имея живую массу 351,8 кг, а молодняк весеннего сезона рождения I группы — 326,8 кг. Преимущество телок зимнего сезона рождения было больше на 24,9 кг, или на 7,6% (Р≤0,001) по сравнению со сверстницами весеннего сезона рождения. Телки ΙΙ группы превосходили по среднесуточному приросту особей I группы на 49 г, или на 8,4% (Р<0,001), достоверные различия были и по промерам телосложения в пользу животных II группы по сравнению с I группой.
The article presents the results of growing Kalmyk heifers of different birth seasons in the foothill zone of Dagestan. It has been established that the cultivation of animals using the technology of beef cattle breeding allows them to increase their live weight by the age of 18 months. At 8 months, heifers of the winter birth season (experimental group II) outperformed their peers born in the spring (control group I) by 14.4 kg, or by 8.3% (P≤0.01). At 12 months of age, they reached a body weight of 253.4 kg, which was more than that of their peers of the spring birth season by 17.6 kg, or 7.5% (P≤0.01). At 18 months the heifers of the I group maintained a high growth rate, having a live weight of 351.8 kg, and the young of the spring season of birth of the I (control) group — 326.8 kg. The advantage of heifers of the winter birth season was greater by 24.9 kg, or by 7.6% at (P≤0.001 compared to peers of the spring birth season. The heifers of group II exceeded the average daily growth of individuals of group I by 49 g, or by 8.4% at (P<0.001), there were significant differences in body size in favor of group II animals compared to group I.
Hubungan Pengetahuan Dengan Self Awareness Perawat Dalam Pencegahan Covid-19 Diruangan Internis Rumah Sakit Santa Elisabeth Medan
Authors: Simbolon Pomarida , Novitarum Lilis , Panjaitan Farida , Derang Imelda 
Published: July 2023

Kesadaran seorang perawat akan dirinya, bahwa dia percaya dan mampu dalam melakukan tindakan pencegahan corona virus disease (COVID-19) berkaitan dengan pengetahuan seseorang dalam melakukan tindakan. Pengetahuan adalah hasil pengindraan manusia, atau hasil tahu seseorang terhadap pencegahan corona virus disease (COVID-19). Tujuan penelitian untuk mengetahui hubungan pengetahuan dengan self-Awareness perawat dalam pencegahan corona virus disease (COVID-19) di Ruangan Internis Rumah Sakit Santa Elisabeth Medan. Jenis penelitian ini deskriptif analitik dengan desain cross sectional. Populasi dalam penelitian seluruh perawat di Ruangan Internis Rumah Sakit Santa Elisabeth Medan dengan jumlah sampel 39 orang. Teknik pengambilan sampel menggunakan simple random sampling. Pengumpulan data menggunakan lembar kuesioner. Analisa data dengan menggunakan uji chi-square. Hasil penelitian diperoleh pengetahuan baik 26 orang (66,7%), self-awareness baik 20 orang (51,3%). Hasil uji statistik chi-square diperoleh p-value = 0,009 (p<0,05) hal ini menunjukkan bahwa ada hubungan yang bermakna antara pengetahuan dengan self-awareness perawat dalam pencegahan corona virus disease (COVID-19) di ruangan internis Rumah Sakit Santa Elisabeth Medan tahun 2021. Diharapkan perawat mampu meningkatkan pengetahuan tentang pentingnya self-awareness dengan baik sehingga pencegahan corona virus disease (COVID-19) dapat dilaksanakan dengan baik.