bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method for lung inflation determining in asthma patients with osmotic airway hyperresponsiveness
Authors: Afanas'eva E. Yu. 
Published: December 2022

Aim. To develop a method for determining the lung inflation by the indexes of forced expiratory flow­volume spirometry.Materials and methods. In 43 patients with mild persistent uncontrolled asthma in combination with osmotic airway hyperresponsiveness, the lung function indexes were assessed by spirometry using a bronchodilation test and bodyplethysmography.Results. From the entire set of parameters, using regression analysis, two equations were con­structed, with the inclusion of the main spirometric indicators (FEV1 in % of the due value, AFEVt and AFEF75 after the bronchodilation test, in %). The equations obtained make it possible to calculate lung inflation indices in asthma patients with osmotic airway hyperresponsiveness to select patients for referral for bodyplethysmography and multispiral computed tomography of the lungs in order to diagnose the severity of hyperinflation.Conclusion. The developed regression models provide an opportunity for a preliminary assessment of the presence and degree of lung hyperinflation in asthma patients with osmotic airway hyperresponsiveness, to determine personal approaches to basic anti-inflammatory therapy and, if necessary, to correct it in a timely manner.
Immuno-hormonal and dopplerometric characteristics of placental insufficiency in pregnant women with exacerbation of chronic bronchitis associated with reactivation of cytomegalovirus infection
Authors: Nakhamchen L. G. , Gorikov I. N. , Kolosov V. P. , Odireev A. N. , Andrievskay I. A. , Ishutina N. A. , Bushmanov A. V. , Dovzhikova I. V. 
Published: December 2022

Aim. To give immune-hormonal and dopplerometric characteristics of placental insufficiency in pregnant women with exacerbation of chronic bronchitis associated with reactivation of cytomegalovirus infection (CMVI).Ma­terials and methods. The concentration of IL-ie, IL-2 and progesterone was studied in the blood serum, and the pulsation index (PI) in the right uterine artery (RUA) was determined in 80 patients at 21-24 weeks of gestation, uncomplicated and complicated by exacerbation of chronic simple bronchitis due to reactivation of CMVI. In a retrospective analysis, 3 groups were formed. The first group - 30 women with CMV-seronegative physiological pregnancy; the second - 25 patients with chronic bronchitis in the acute stage, initiated by the acute phase of CMVI, leading to chronic compensated placental in­sufficiency (CCPI); the third - 25 women with exacerbation of chronic bronchitis CMVI etiology, causing the development of chronic subcompensated placental insufficiency (CSPI) in the third trimester of gestation.Results. In the first group, the concentration of IL-ie was 22.8±0.02 pg/mL, IL-2 - 30.6±2.34 pg/mL, progesterone - 130.8±8.19 nmol/L, and the value of PI in RUA - 0.83±0.04 rel. units. In patients of the second group, compared with the first, the level of IL-ie in­creased by 3.82 times (p<0.00i), IL-2 - by 2.55 times (p<0.00i) and PI in the RUA - by i.40 times (p<0.00i) against the background of a decrease in the progesterone concentration by i.47 times (p<0.00i). The third group compared with the first was characterized by an increase in the concentration of IL-ie by 6.87 times (p<0.001), IL-2 - by 3.19 times (p<0.001) and PI in RUA by i.66 times (p<0.00i) with lower levels of progesterone (i.93 times, p<0.00i). In the third group, in contrast to the second one, an increase in IL-ie was observed by 1.79 times (p<0.001), IL-2 - by 1.24 times (p<0.05) and PI in RUA - by i.i7 times (p<0.05), as well as a decrease in progesterone levels by i.3i times (p<0.0i). There was an in­crease in the relationship of PI in RUA with the concentration of IL-ie (r=0.69; p<0.001), IL-2 (r=0.75; p<0.001) and progesterone (r=-0.55; p<0.01).Conclusion. A more pronounced systemic inflammatory reaction, leading to inhibition of progesterone synthesis and increased resistance to blood flow at RUA develops in exacerbation of chronic bronchitis in the second trimester of gestation against the background of reactivation of CMVI, which initiates the development of CCPI, in comparison with the exacerbation of bronchopulmonary pathology of a similar etiology, which determines the formation of subsequent CCPI.
GIANDOMENICO AMENDOLA. LA CIUDAD POSTMODERNA MADRID: CELESTE EDICIONES, 2000. 379 P.
Authors: De Almeida Vasconcelos Pedro 
Published: December 2022

Trata-se da tradução (Marisa García Vergaray e Paulo Sustersic) do livro La città posmoderna. Magie e paure della metropoli contemporânea, de 1997. O interesse principal deste livro está no olhar de um sociólogo italiano, professor da Escola de Arquitetura da Universidade de Florença, que pode ser contraposto à recente literatura anglo-americana sobre a mesma temática, como, por exemplo, os textos de Nan Elin (1996), Edward Soja (2000) ou Michael J. Dear (2000).
Estudo do mapa de percurso articulado ao museu interativo e à Modelagem na Educação como estratégia de compreensão do bioma local
Authors: Silva Yasmin Mascarenhas da , Duarte Leodenil Alves , Viana Valdirene Teixeira Flor , Ribeiro Dilson Ferreira , Lara Isabel Cristina Machado de 
Published: December 2022

Este estudo tem como objetivo analisar os resultados da aplicação de uma proposta de ensino que procurou desenvolver um olhar sensibilizado sobre o bioma local por meio do envolvimento dos estudantes na construção colaborativa de um mapa de percurso de casa à escola, de modo a propiciar noções e questionamentos sobre a biodiversidade presente em sua região. Tal proposta utilizou o Museu de Ciências e Tecnologia da Pontifícia Universidade Católica do Rio Grande do Sul como recurso pedagógico e a Modelagem na Educação em Ciências e Matemática enquanto método de ensino. A pesquisa é de natureza qualitativa, desenvolvida com estudantes do sexto ano do Ensino Fundamental. Os dados foram coletados por meio de pré e pós-questionário, os quais foram analisados com base no método da Análise Textual Discursiva. Como resultado, evidenciou-se que a construção do mapa de percurso contribuiu no desenvolvimento da percepção de que o bioma está presente no trajeto de casa à escola e que a sua relação com o ambiente afeta diretamente o bioma local. Além disso, constatou-se que os recursos possibilitados pelo museu interativo e pela Modelagem contribuíram para a compreensão de conceitos fundamentais para o desenvolvimento da proposta de ensino por meio da interdisciplinaridade.
Características de uso de narguile en estudiantes de ciencias médicas: riesgo carcinogénico
Authors: Prata do Carmo Isaque 
Published: December 2022

Introducción. El consumo temprano de tabaco está relacionado con varios criterios, es considerado como la principal causa aislada prevenible de enfermedad y muerte prematura, es un factor de riesgo importante para el cáncer oral, situación que inicia antes de los 20 años. Por lo tanto, la finalidad del estudio fue establecer características de uso de narguile en estudiantes de ciencias médicas. Metodología: Estudio epidemiológico, cuantitativo, transversal, descriptivo, con estudiantes de la carrera de medicina, la técnica utilizada fue una encuesta en línea. El análisis estadístico se dio mediante tabulación en software (Excel). Resultados: se identificó que la prevalencia de utilización de narguile fue de 18 %, siendo usada predominantemente por: hombres (62 %), grupo etario entre 22-27 años (48 %), solteros (79 %) y residente Brasileia (60 %) la cual 40 % viven solos 31 % conviven con personas que fuman. De estos, el 43 % comenzó a emplearlo entre los 15 y los 18 años antes de ingresar en la universidad (71 %). Discusión: Es de suma importancia abordar el tema en las instituciones educativas de todos los niveles e informar a los estudiantes sobre los perjuicios que ocasiona el uso de la cachimba a corto, mediano y largo plazo, principalmente porque existe estudios que evidencian la relación con cáncer, principalmente en vía oral.
Analisis perbandingan Codeigniter dan Yii framework pada perancangan website rencana anggaran biaya
Authors: Suwarno Suwarno , Afandi  
Published: December 2022

Perhitungan biaya dalam membangun sebuah rumah menjadi hal yang perlu dipertimbangkan. Dalam perhitungan pembangunan rumah saat ini masih banyak yang melakukan dengan cara manual sehingga memungkinkan terjadi kesalahan perhitungan biaya dan material. Dengan adanya sistem komputerisasi memberikan dampak pada kehidupan masyarakat dalam melakukan perhitungan biaya pembangunan rumah ini. Sistem komputerisasi juga didukung oleh software dan hardware. Dalam membangun perangkat lunak menggunakan berbagai jenis bahasa pemrograman. Salah satunya adalah pemrograman PHP. Untuk mempercepat perancangan sebuah aplikasi web, diperlukan framework. Framework pada bahasa pemrograman PHP yang dikenal umum memiliki performa baik yaitu Codeigniter, Yii dan Laravel. Namun pada penelitian ini dilakukan untuk mengetahui perbandingan dua framework Codeigniter dan Yii. Penulis merancang aplikasi berbasis web untuk menyusun rencana anggaran biaya (RAB) dengan dua framework yaitu Codeigniter dan Yii Framework. Serta membandingkan kedua framework yang dirancang menggunakan diagram blok. Perbandingan yang tergolong dalam diagram blok adalah baris pada kode program, efisiensi kode, kecepatan web, struktural folder dan URL, arsitektur dan keamanan web. Perbandingan kedua framework memiliki perbedaan pada kecepatan web dan keamanan web. Yii framework lebih unggul dalam kecepatan pada pengujian speed index sama hal dengan pengujian keamanan, Codeigniter framework memiliki keamanan yang lebih rendah dibandingkan Yii framework.
“Primum Non Nocere”: Ameliyathanedeki Sağlık Profesyonellerinin Hasta Güvenliğine İlişkin Tutumlarının İncelenmesi
Authors: SAVCİ Aysegul , KARACABAY Kevser , ÖZTÜRK Betül , SÜTSÜNBÜLOĞLU Emel , YÜKSEL Burcu 
Published: December 2022

Çalışmada	ameliyathanedeki sağlık profesyonellerinin hasta güvenliğine ilişkin tutumlarının incelenmesi amaçlandı. Tanımlayıcı tipte olan çalışma 15 Ağustos 2020– 15 Mart 2021 tarihleri arasında ameliyathanede çalışan 201 sağlık profesyoneli ile gerçekleştirildi. Katılımcıların %73,6’sı kadın, %53,2’si lisans mezunu, %65,7’si ameliyathane hemşiresiydi. Ameliyathanede Güvenlik Tutumları Ölçeği toplam puan ortalaması 58,67 ± 13,62’dir. Katılımcılarımız ölçeğin alt boyutlarının çoğunluğunda ortalamanın üzerinde puanlar alırken, stres düzeyinin belirlenmesi boyutunda düşük puan aldılar. Ameliyathane teknikerlerinin, sağlık meslek lisesi/ön lisans mezunlarının ve kurumunda günlük gerçekleştirilen cerrahi girişim sayısı 0-9 olan katılımcıların güvenlik tutumlarının daha yüksek olduğu belirlendi. Çalışma saatleri dışında yeterince dinlenebildiğini düşünen ve hizmet içi eğitim programlarının belirlenmesinde gereksinimleri dikkate alınan katılımcıların güvenlik tutumları puanının daha yüksek olduğu belirlendi. Güvenli cerrahinin temelini oluşturan ve kalite göstergelerinden birisi olan hasta güvenliği kavramı ameliyathanedeki sağlık profesyonelleri için oldukça önemlidir. Ameliyathanedeki sağlık profesyonellerinin güvenlik tutumlarının geliştirilmesi gerektiği saptanmıştır.
Deep Orbital Search for Additional Planets in the HR 8799 System
Authors: Thompson William , Marois Christian , Do Ó Clarissa R. , Konopacky Quinn , Ruffio Jean-Baptiste , Wang Jason , Skemer Andy J. , De Rosa Robert J. , Macintosh Bruce 
Published: December 2022

Abstract
The HR 8799 system hosts four massive planets orbiting 15 and 80 au. Studies of the system's orbital stability and its outer debris disk open the possibility of additional planets, both interior to and exterior to the known system. Reaching a sufficient sensitivity to search for interior planets is very challenging due to the combination of bright quasi-static speckle noise close to the stellar diffraction core and relatively fast orbital motion. In this work, we present a deep L-band imaging campaign using NIRC2 at Keck comprising 14 observing sequences. We further re-reduce archival data for a total of 16.75 hr, one of the largest uniform data sets of a single direct imaging target. Using a Bayesian modeling technique for detecting planets in images while compensating for plausible orbital motion, we then present deep limits on the existence of additional planets in the HR 8799 system. The final combination shows a tentative candidate, consistent with 4–7 M
jup at 4–5 au, detected with an equivalent false-alarm probability better than 3σ. This analysis technique is widely applicable to archival data and to new observations from upcoming missions that revisit targets at multiple epochs.
FN8-23-7179: A Low-temperature Circumstellar Shell?
Authors: Moody J. Ward , Steele Rochelle J. 
Published: December 2022

Abstract
In the course of a narrow-band imaging survey for dwarf emission-line galaxies in a nearby void, we serendipitously discovered a low-excitation nebula that fits the profile of a shell surrounding a low-temperature star. The star has a parallax of 0.47 ± 0.34 mas with a most likely distance of 1686 pc. It has apparent magnitudes in

r
′

and g of 18.5 and 19.54, absolute magnitudes

M

r
′

and M

g
of 7.4 and 8.41, and a redshift of 140 km−1. The color and magnitude are consistent with a K6V dwarf. A lack of forbidden emission suggests that the nebular electron temperature is < 3500° K.
New Cholesteryl Ester Transfer Protein from Indonesian Herbal Plants as Candidate Treatment of Cardiovascular Disease
Authors: Yudhani Ratih Dewi , Fahrurrozi Khariz , Indarto Dono 
Published: December 2022

BACKGROUND: There is a strong negative relationship between high-density lipoprotein cholesterol (HDL-C) and the risk of cardiovascular disease (CVD). Cholesterol ester transfer protein (CETP) is a glycoprotein transporter that transfers cholesterol esters to very low-density lipoprotein and low-density lipoprotein cholesterol (LDL-C). The CETP inhibitor is a new strategy against CVD because of its ability to increase HDL-C. Various Indonesian plants have not been optimally used, and in silico phytochemical screening of these plants showing potential as CETP inhibitors is still limited. AIM: This study for exploring Indonesian phytochemicals as CETP inhibitors for new CVD treatments. METHODS: We screened 457 phytochemicals registered in the herbal database and met Lipinski’s rule of five. Their molecular structures were downloaded from the PubChem database. The three-dimensional structures of CETP and dalcetrapib (the CETP inhibitor standard) were obtained from a protein data bank (http://www.rcsb.org/pdb/) with the 4EWS code and ZINC database with the ZINC03976476 code, respectively. CETP–dalcetrapib binding complexes were validated 5 times using AutoDock Vina 1.1.2 software. Interactions between CETP and phytochemicals were molecularly docked with the same software and visualized using Pymol 1.8× software. RESULTS: Dalcetrapib had a docking score of −9.22 kcal/mol and bound to CETP at Ser230 and His232 residues. The 11 phytochemicals had lower binding scores than dalcetrapib, but only L-(+)-tartaric acid, chitranone, and oxoxylopine could interact with CETP at the Ser230 residue. These are commonly found in Tamarindus indica, Plumbago zeylanica, and Annona reticulata, respectively. CONCLUSION: L-(+)-Tartaric acid, chitranone, and oxoxylopine show potential as CETP inhibitors in silico.
Return of Coal: A Short Visit or a Long Stay?
Authors: Medzhidova Dzhanneta 
Published: December 2022

Despite the existence of global targets to slow the pace of climate change, coal remains one of the most commonly used fuels that accounts for over 25% of the global energy supply and consumption. Multiple factors explain why coal is still widely used: its relatively low prices, availability in developing countries, low transportation costs and path dependence, i.e. the existing energy infrastructure. Coal consumption in developing (non-OECD) countries has been rising thanks to the processes in India and China but in 2021, however, it increased in the OECD countries as well. The uneven and often atypical post-COVID-19 recovery driven by manufacturing created disruptions in energy markets with high and volatile prices of coal’s main substitute - natural gas. The first in history and hence unexpected slowdown in the RES supply in 2021 added to the reversal of trends exactly at the time of the COP26 in Glasgow.
The goal of our study is to examine the coal markets in the new complex environment determined by both economic and political factors: high commodity prices, rising inflation, decelerating economic growth, and sanctions against exporters. In this paper we analyze the major trends before 2020, the current processes, and their implications for the future in the context of choice between economic development and energy transition including the issue of stranded assets and their possible reopening.
A Study on Common Aeroallergens in a Coastal City of South India by Skin Prick Test
Authors: Moleyar Vishnu Sharma , Bali Abhishek 
Published: December 2022

Introduction:
Airborne allergens are the major cause of allergic respiratory diseases worldwide, they are present all around, suspended in the air we breathe, spanning different regions, invisible to the naked eye, while causing allergic respiratory flare-ups in susceptible individuals. Although present globally they have a unique distribution which depends on geographic and climatic factors. Hence, a select broad group of allergens cannot be accountable for causing allergic responses worldwide. It is therefore imperative to identify the offending allergens causing flare-ups in patients living in a particular region, to effectively tackle exacerbations.

Objectives of Study:
(1) To study the clinical profile of patients with rhinobronchial allergies, (2) To determine endemically common aeroallergens for patients with rhino bronchial allergies from Dakshina Kannada District, presenting at A. J. Institute of Medical Sciences, Mangalore, by means of skin prick test (SPT).

Materials and Methods:
A total of 170 patients with preexisting allergic airway diseases were included in the study over a duration of 12 months. These subjects were screened, history was taken, and then subjected to an SPT after acquiring an informed consent. A customized panel of 55 allergens was used in the test comprising dust/dust mite, animal, fungal, insect, and plant-based allergens. A wheal size of more than 3 mm was considered as a positive reaction and the findings were recorded.

Results:
This study included 97 male and 73 female patients, with the mean age of the patients being 33.7 years. The most common aeroallergen was found to be, Parthenium hysterophorus, followed by Dermatophagoides farine a dust mite, Typha angustata, Cyperus Rotundus, Mangifera indica, Ischaemum, and Prosopis juliflora. Cockroach, dog epithelia, and Aspergillus fumigatus were found to be most allergenic in each respective group, i.e., insect, animal, and fungal group.

Conclusion:
Our study showed predominantly pollen-based allergens from mainly invasive wild grasses and small plants to be causing allergic respiratory diseases in susceptible individuals, especially young adults, living in Dakshina Kannada District, Karnataka. Allergic respiratory diseases due to Dust mite D. Farine were found to cause allergic manifestation in mainly urban population included in the study. A. fumigatus, dog epithelia, and cockroach were found to be the most common antigens causing allergic reactions in each respective category.
Evaluation of the Cytonucleomorphometric Parameters for Cases Diagnosed as Squamous Cell Abnormality on Conventional Cervico-Vaginal Pap Smears
Authors: Mishra Satyam , Khurana Ujjawal , Kapoor Neelkamal , Joshi Ankur , Joshi Deepti 
Published: December 2022

Background and Aim:
The natural history of cervical cancer is unique that it is preceded by a precancerous condition for a long time. Morphometry as a tool can be used in early and accurate diagnosis of these precancerous and cancerous lesions. The present study aims at assessing the utility of cellular and nuclear morphometry in differentiating squamous cell abnormality from benign conditions and also differentiating the categories of squamous cell abnormalities.

Materials and Methods:
Forty-eight diagnosed cases of squamous epithelial cell abnormality, that is, 10 cases each of atypical squamous cell of undetermined significance (ASC-US), low-grade squamous intraepithelial lesion (LSIL), high-grade SIL (HSIL), and squamous cell carcinoma (SCC) and eight cases of ASC-H (ASC cannot exclude HSIL), were made the sample population and compared with a control population of 10 cases of negative for intraepithelial lesion or malignancy (NILM). Parameters like nuclear area (NA), nuclear perimeter (NP), nuclear diameter (ND), nuclear compactness (NC), cellular area (CA), cellular diameter (CD), cellular perimeter (CP), and nucleocytoplasmic (N/C) ratio were used.

Results:
There was a significant difference in the six groups of squamous cell abnormality based on NA, NP, ND, CA, CP, and CD (P < 0.05) using one-way analysis of variance. Nuclear morphometry parameters like NA, NP, and ND were found to be the maximum for HSIL, followed by LSIL, ASC-H, ASC-US, SCC, and NILM groups in decreasing order. The mean CA, CP, and CD were found to be the maximum for NILM, followed by LSIL, ASC-US, HSIL, ASC-H, and SCC in decreasing order. On post hoc analysis, the lesions can be divided into three groups: NILM/normal; ASC-US and LSIL; and ASC-H, HSIL, and SCC, based on N/C ratio.

Conclusion:
In cervical lesions, holistic parameter of cytonucleomorphometry should be taken rather than taking nuclear morphometry only. N/C ratio is a highly statistically significant parameter that can differentiate between low-grade lesions and high-grade lesions.
Podaci o markiranosti leksema u dvojezičkim rječnicima / Usage labels in bilingual dictionaries
Authors: Čović-Filipović Alma 
Published: December 2022

The paper examines the issue of indicating lexeme markedness in bilingual dictionaries. Markedness goes beyond the denotative meaning of lexemes and is considered to be the information referring to the lexical knowledge that must be given to the dictionary user in order for their lexical selection to be adequate for the communicative situation they might find themselves in. This information comprises, for example, data on the stylistic, temporal, and regional markedness of lexical units. In the first part of the paper, a theoretical overview of markedness in lexicography is presented. In the empirical part, the lexicographic practice of markedness is investigated using the example of the lexemes from the semantic field TO DIE in the Croatian German dictionary by Jakić and Hurm (1999). Suggestions for labelling markedness in the Bosnian-German universal dictionary (BNJUR), which is in the process of being created, are proposed as well. The goals of this research are: (1) to determine the representation of pragmatic information at the macrostructural level in the Croatian-German dictionary by Jakić and Hurm (1999); (2) to determine the representation of pragmatic information in the dictionary articles in the form of usage labels and ways of presenting their lexicographic description. Here, it is also important to determine a) for which language elements the label is specified and b) for how many elements the specified label “is valid”; (3) to propose concrete solutions for improving the labelling of pragmatic information in BNJUR, keeping in mind the needs of its target users. The analysis indicated several shortcomings in lexicographic practice, ranging from listing equivalents that are marked differently in relation to the entry, not listing usage labels for marking in general, to ambiguities regarding what the usage labels refer to.