bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extensive spinal epidural abscess after nerve root injection in a young non-immunocompromised Patient. Case Report and Literature Review.
Authors: Holc Fernando , Albani Forneris Agustin , Camino Willhuber Gaston , Kido Gonzalo , Gruenberg Marcelo , Sola Carlos , Pereira Duarte Matias 
Published: April 2023

Introduction: Epidural injections are frequent and safe procedures. Severe complications are infrequent, and they have been reported in elderly comorbid patients with predisposing factors. The objectives of this work are to present a case of an extensive epidural lumbar abscess in a young non-comorbid male patient after a therapeutic L5-S1 injection and a literature review about this subject.

Case Presentation
An otherwise healthy 24-year-old man who present a case of an extensive epidural lumbar abscess after a therapeutic nerve root block due to a disc herniation. After 7 days of fever and low back pain, he required two surgical interventions and intravenous antibiotic therapy.
We reviewed 18 patients with epidural abscess consequence of spinal injections. Their mean age was 54.5 y.o, 66.5% were male, and 66.5% had at least one predisposing risk factor. Symptoms Onset occurred at 8 days on average after the procedure, but the correct diagnosis was made at the 25th-day average. Only 22% presented the classic diagnostic triad, the most frequently isolated germ was Staphylococcus Aureus (66%) and 89% were treated surgically with a 33% rate of complete recovery, 17% mortality and 28% remained with neurological sequelae.

Conclusion:
Epidural abscesses are infrequent and serious, complication after spinal diagnostic and therapeutic injections, even in young patients without comorbidities. We consider it fundamental to maintain a diagnostic suspicion, even in this subgroup of patients.
Analisis Pertumbuhan Laba Pada PT. Toba Pulp Lestari Tbk
Authors: Br. Tungkir Agustina , Herosian Mila Yulia , Manalu Maria Cendika , Syahri M. Alvi 
Published: April 2023

This study aims to determine and analyze profit growth on financial ratios Current Ratio, Debt To Assets Ratio, and Total Assets Turn Over at the company PT. Toba Pulp Lestari Tbk. This research method is quantitative method with quantitative descriptive research. Data collection techniques using documentation techniques. The independent variables in this study are the Current Ratio, Debt To Assets Ratio, and Total Assets Turn Over. The dependent variable in this study is profit growth. Data analysis used multiple linear regression analysis. The results of this study indicate that the F test value obtained is Fcount of 5.571 with a significant value of 0.065>0.05. The results of the T test show, a) the CR variable has a tcount of -0.099 with a significant value of 0.926>0.05; b) the DAR variable has a value of -tcount< ttable that is -3.662<2.0150; c) the TATO variable has a tcount of -0.916 with a significant value of 0.411>0.05. In conclusion, partially Current Ratio, Debt To Assetsratio, and Total Assets Turn Over have no effect on profit growth at PT. Toba Pulp Lestari Tbk. Simultaneously Current Ratio, Debt To Assets Ratio, and Total Assets Turn Over together affect profit growth at PT. Toba Pulp Lestari Tbk.
Keywords: Current Ratio, Debt to Assets Ratio, Profit Growth, Total Assets Turn Over
Pengaruh Budaya Organisasi Dan Lingkungan Kerja Terhadap Kinerja Pegawai Pada Dinas Pendidikan, Pemuda Dan Olahraga (Disdikpora) Kabupaten Karawang
Authors: Yulia Dede , Arnu Anggi Pasca 
Published: April 2023

This study aims to determine the partial and simultaneous influence between organizational culture, employee work environment on the performance of the employees of the Department of Education, Youth and Sports (DISDIKPORA), Karawang Regency. The method used in this research is descriptive and verification methods. The population in this study were 267 employees of the Office of Education, Youth and Sports (DISDIKPORA) Karawang Regency. The sample used in this study amounted to 157 employees. The sampling technique used in this study is a simple random sampling technique. The results showed that there was a partial influence of 28.2% between Organizational Culture on employee performance and there was a partial influence between the work environment and employee performance by 19.3%. Meanwhile, the simultaneous influence between organizational culture and work environment on employee performance is 47.5% and the influence of other variables outside the model is 52.5%. 47.5%.
Keywords: Organizational Culture, Work Environment, Employee Performance.
Pengaruh Investment Opportunity Set Dan Kepemilikan Manajerial Terhadap Nilai Perusahaan Dengan Kebijakan Hutang Sebagai Variabel Intervening
Authors: Oktabrina Sheyla Salima , Inggarwati Komala 
Published: April 2023

This study aims to determine the effect of Investment Opportunity Set and Managerial Ownership to Firm Value through Debt Policy as Intervening Variable at Manufacture Company. The sample in this study were 27 companies from sub-sector Industrials. Stages of testing include outer model, reliability and consistency, convergent and discriminant validity, inner model, coefficient determinations, effect size, prediction relevance, and path coefficient. The analysis used in this research is SEM-PLS. The result showed that; (1) Investment opportunity set positively influences firm value, (2) Managerial ownership has no effect on firm value, (3) Investment opportunity set negatively influences debt policy, (4) Managerial ownership has no effect on debt policy, (5) Debt policy positively influences firm value (6) Investment opportunity set negatively influences firm value with debt policy as intervening variable, (7) Managerial ownership has no effect on firm value with debt policy as intervening variable.
Keywords: Investment opportunity set, managerial ownership, firm value, debt policy
The Pengaruh Current Ratio, Receivable Turnover Ratio Dan Debt To Asset Ratio Terhadap Profitabilitas (Studi Pada Perusahaan Manufaktur Sektor Industri Barang Konsumsi Yang Terdaftar Di BEI Tahun 2015-2020)
Authors: Nisa Fachrun , Nurhasanah Nunung , Kosasih Kosasih 
Published: April 2023

The purpose of this study was to determine the current ratio (CR), receivable turnover ratio (RTR) and debt to asset ratio (DAR) on profitability. Profitability is measured using net profit margin (NPM). The research conducted in this research is descriptive with a quantitative approach. The population in this study are manufacturing companies in the consumer goods industry sector listed on the Indonesia Stock Exchange (IDX) in 2015 – 2020. The sample of research data is 120. Based on the results of the study, that simultaneously CR, RTR, DAR affect NPM with a significant level of 0.008. Partially CR has a significant effect on NPM with a significant level of 0.048. Furthermore, RTR has a significant effect on NPM with a significant level of 0.003. And DAR has no effect on NPM with a significant level of 0.181.
Keywords: CR, RTR, DAR, NPM
Pengaruh Keselamatan Kerja, Sistem Kerja, Dan Motivasi Kerja Terhadap Kinerja Karyawan Di Toko Jaya Raya Showroom Cabang Imam Bonjol
Authors: Sri Wahyuni Putu Mas , Adnyana I Putu Agus 
Published: April 2023

This study aims to determine the effect of work safety, work systems and work motivation on employee performance at the Jaya Raya Store Showroom, Imam Bonjol Branch. The questionnaire technique method (questionnaire data collection) was used in this study. The data used can be calculated directly as numbers or variables and the data that can be measured is a type of quantitative data. In this study, there were 40 employees of Toko Jaya Raya Showroom, Imam Bonjol Branch as a sample. The data analysis method applied is the multiple linear analysis method using SPSS 18.0 tools. The results of the research obtained in this study are: 1. The work safety variable (X1) has a positive and significant influence, 2. The work system variable (X2) has a positive and insignificant effect, 3. The work motivation variable (X3) has a positive and significant impact. positive and significant impact on employee performance at Toko Jaya Raya Showroom Imam Bonjol Branch.

Keywords: work safety, work system, work motivation, and employee performance
Pengaruh Good Corporate Governance (GCG) Dan Corporate Social Responsibility (CSR) Terhadap Kinerja Keuangan Perbankan Yang Terdaftar Di Indonesia Stock Exchange (IDX)
Authors: Puspita Anisa Dewi , Kartini Tina 
Published: April 2023

The purpose of this study is to determine whether there is an effect of Good Corporate Governance (GCG) and Corporate Social Responsibility (CSR) on the financial performance of banks listed on the Indonesia Stock Exchange (IDX) in 2019-2021. This study aims to influence; 1) Effect of GCG with audit committee indicators on financial performance (ROA), Effect of CSR on ROA, and 3) Effect of GCG and CSR on ROA. The variables used in this study are the independent variable and the dependent variable. This research is a research that uses quantitative research methods. The population and sample in this study are the company's financial ratio reports. In this study, the writing used data collection techniques with secondary data. Using statistical methods. The results showed that; 1) The audit committee has no positive and significant effect on banking financial performance, 2) Corporate Social Responsibility has no effect on banking financial performance, 3) the audit committee and Corporate Social Responsibility simultaneously (simultaneously) affect financial performance.

Keywords : Good Corporate Governance, Audit Committee, Corporate Social Responsibility, Return On Assets.
Teknik Analisa Fundamental Dalam Mempengaruhi Return Saham Dengan Harga Saham Sebagai Variabel Moderating
Authors: Affiffa Adi Mila Nur , Kartika Andi 
Published: April 2023

The capital market is an important instrument in the development of the world economy. Every year the capital market develops very rapidly with evidence of an increase in the number of outstanding shares and a high volume of stock trading. This study aims to analyze fundamentals that affect stock returns including CR, DER and ROA and to test whether stock prices are able to moderate the relationship between these variables. This research was conducted on food and beverages companies listed on the Indonesia Stock Exchange from 2016 to 2020. The data used is the financial report (annual report). The sampling method used purposive sampling method. Test to see the effect using multiple linear regression analysis. The results showed that CR had a significant negative effect on stock returns. DER has a significant positive effect on stock returns. ROA has a significant negative effect on stock returns. Stock prices are able to moderate the relationship of CR, DER and ROA to stock returns with a weakening function. The coefficient of determination test shows that CR, DER and ROA are able to provide an overview of changes in stock prices of 63.9% and the remaining 36.1% is influenced by other variables outside the study.
Keywords : current ratio, debt to equity ratio, return on assets, stock return, stock price
Pengaruh Usia dalam Kepemimpinan Transformasional dan Keterikatan Kerja pada Perusahaan
Authors: Sukmarani Sukmarani 
Published: April 2023

This study aims to determine the relationship between transformational leadership with work engagement on employees in company X at the age as a control subject. This research method is quantitative research. The research subjects were 56 people who were selected by non-probability sampling technique, saturated sampling. Work engagement and transformational leadership are measured using a work engagement scale called UWES-17 which consists of 17 items and a transformational leadership scale. Correlation test with partial correlation technique was used to analyze SPSS 16.0 for Windows. The results showed that there was a positive and significant relationship between transformational leadership and control of work engagement according to age with a value of r = 0.407, p = 0.002 (p < 0.05). In conclusion, work engagement and transformational leadership of Company X are high. Most aspects of transformational leadership are related to this aspect of work engagement. The correlation between transformational leadership and job involvement is influenced by various factors such as age and gender.
Keywords: Transformational Leadership, Job Engagement, Perception
Komunikasi, Disiplin Kerja, dan Motivasi terhadap Kepuasan Kerja Karyawan
Authors: Steven Michael , Yunior Khomeiny , Tommy Tommy , Vincent Vincent 
Published: April 2023

This study aims to examine and analyze the influence of communication, discipline, motivation on job satisfaction at PT Alfa Scorpii. This research method is quantitative with the sample used is 147 people. The sampling method is simple random sampling. Methods of data analysis using multiple linear regression. The results showed that the t test on the communication variable with value (5.136> 1.976), discipline (3.742> 1.976) and motivation (6.836> 1.976). The results of the F test show a value of 40.189> 2.67. In conclusion, partially has a positive and significant effect on job satisfaction at PT Alfa Scorpii. Simultaneously, the variables of communication, discipline and motivation show a positive and significant impact on customer satisfaction at PT Alfa Scorpii.
Keywords: Discipline, Job Satisfaction, Communication, Motivation
Dampak Situasi Pandemi COVID-19 terhadap Tumbuh Kembang Anak
Authors: Mulyani Imas , Wanda Dessie , Agustini Nur 
Published: April 2023

This study aims to determine the impact of the COVID-19 pandemic situation on children's growth and development. The method used is a systematic study examining 11 articles related to the effects of the COVID-19 pandemic on children's growth and development using ProQuest, CINAHL, Wiley, PubMed and ScienceDirect. The results showed that the COVID-19 pandemic had an impact on children's growth, social development of children's independence, language, fine motor skills, and gross motor skills. In conclusion, the destructive effects experienced by children while at home are stress, no opportunity to play with friends, reduced activity, weight gain, longer sleep time, increased sitting time and increased screen time. The good impact of this pandemic on individual children is that there is a positive adaptation to the process of growth and development through the maturation process and the social bonding of children and parents becomes closer.
Keywords: Children, Parents, COVID-19 Pandemic, Stimulation of Growth
Efektivitas Media Video Animasi dan E-Book terhadap Pengetahuan Remaja dalam Penatalaksanaan Penyalahgunaan Narkoba
Authors: Triana Winda , Irfan Ary , Sayuti Solihin , Alfari Alfari 
Published: April 2023

This study aims to determine the effectiveness of animated video media and e-books on adolescent knowledge in managing drug abuse at SMPN 19 Jambi City. The method used is a quasi-experimental two-group pretest-posttest. This research was conducted at SMPN 19 Jambi City, involving 47 respondents. The sampling technique was carried out by proportional random sampling and analyzed using the paired sample t-test. The results showed that the average value of knowledge before and after being given education with animated video media and e-books increased. The average difference in knowledge before and after being given health education with animated video media is 1.3; the difference in the average value of knowledge before and after being given health education with e-book media is 1.25%; the p-value of knowledge after providing education using animated videos is 0.001, while e-books are 0.000. In conclusion, animated video media and e-books effectively increase adolescent knowledge in managing drug abuse at SMPN 19 Jambi City.
Keywords: E-Book, Knowledge, Youth, Animated Video
Causal association between obstructive sleep apnea and gastroesophageal reflux disease: A bidirectional two-sample Mendelian randomization study
Authors: Zhu Qianyin , Hua Lijiangshan , Chen Lingshan , Mu Tingyu , Dong Die , Xu Jiayi , Shen Cuizhen 
Published: April 2023

Objectives: Correlations between obstructive sleep apnea (OSA) and gastroesophageal reflux disease (GERD) have been detected in previous observational studies. However, this association remains uncertain due to the potential presence of selection and confounding biases. Therefore, this bidirectional two-sample Mendelian randomization (MR) study was conducted to evaluate the causal relationship between OSA and GERD.Methods: In this study, instrumental variables (IVs) for OSA were selected from publicly available genetic summary data (27,207 cases and 280,720 controls). Summary statistics for GERD were obtained from a genome-wide association study of 602,604 individuals. The inverse variance weighted (IVW) method was used as the main MR method. The MR-Egger intercept test, MR pleiotropy residual sum and outlier, and leave-one-out analysis were used to detect pleiotropy. Heterogeneity was detected by Cochran’s Q test.Results: The IVW results revealed that OSA [odds ratio (OR): 1.19, 95% confidence interval (CI): 1.11–1.28, p = 8.88E-07] was causally associated with the incidence of GERD. Moreover, there was evidence of GERD leading to OSA in the IVW analysis (OR: 1.44, 95%CI: 1.33–1.57, p = 7.74E-19). No directional pleiotropy was detected by the MR-Egger intercept test (all p &gt; 0.05).Conclusion: This study found that OSA is linked to a higher incidence of GERD, and vice versa. This finding might be helpful for the screening and prevention of these two diseases.
Fungal gut microbiota dysbiosis in systemic lupus erythematosus
Authors: Yang Ping , Xu Rui , Chen Fei , Chen Shanshan , Khan Adeel , Li Liang , Zhang Xiaoshan , Wang Yanbo , Xu Zhipeng , Shen Han 
Published: April 2023

IntroductionDespite recent developments in our comprehension of how the gut microbiota and systemic lupus erythematosus (SLE) are related. The mycobiome: which is a small but crucial part of the gut microbiota and is involved in hosts’ homeostasis and physiological processes, remained unexplored in SLE.MethodsWe profiled the gut fungal mycobiota based on internal transcribed spacer region 1 (ITS1) sequencing for the gut microbial DNA from the SLE individuals with lupus nephritis (LN) (n = 23), SLE without LN (n = 26) and healthy controls (n = 14) enrolled in Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School.ResultsThe ITS sequencing generated a total of 4.63 million valid tags which were stratified into 4,488 operational taxonomic units (OTUs) and identified about 13 phyla and 262 genera. Patients with SLE were characterized with unique fungal flora feature. The fungal microbiomes of the three groups displayed distinct beta diversity from each other. Compared with HC group, the abundance of fungal dysbiosis was reflected in a higher ratio of opportunistic fungi in SLE or LN group, as well as the loss of Rhizopus and Malassezia. The main principal components of the flora between the SLE and LN group were generally consistent. The relative abundance of Vanrija in the fecal fungal community was higher in LN group, while the relative abundance of Fusarium was higher in SLE group. Moreover, our data revealed superior diagnostic accuracy for SLE with the fungal species (e.g. Candida, Meyerozyma). Correlations between gut fungi and clinical parameters were identified by Spearman’s correlation analysis. Interestingly, Aspergillus in SLE patients was positively correlated with ACR, 24 h proteinuria, proteinuria, anti-dsDNA, ANA, and SLEDAI, while Rhizopus was negatively correlated with lymphocytes and Hb. Finally, we successfully cultured the fungi and identified it as Candida glabrata by microscopic observation and mass spectrometry.DiscussionWe first explored the highly significant gut fungal dysbiosis and ecology in patients with SLE, and demonstrated the applicability of fungal species as SLE diagnostic tools, signifying that the gut fungal mycobiome-host interplay can potentially contribute in disease pathogenesis.
Oral health behavior and oral health service utilization among cancer patients in China: A multicenter cross-sectional study
Authors: An Ran , Wu Zitong , Liu Meizi , Zhao Yaqin , Chen Wenfeng 
Published: April 2023

PurposeOral health plays an important role in overall health. But there is scarce information available on oral health behavior and oral health service utilization among cancer patients. This study aimed to evaluate oral health behavior and oral health service utilization among different population groups of cancer patients in China.MethodsA multicenter cross-sectional study in three tertiary hospitals was conducted to explore the oral health behaviors and oral health service utilization of 162 cancer patients in China.ResultsWe investigated a total of 162 cancer patients, 81 from urban and rural areas, respectively. The participant’s ages ranged from 18 and 82 years, mean age was 44.62 years (SD = 15.72). Overall, cancer patients have poor oral health behaviors and limited oral health service utilization. There were statistically significant differences (p &lt; 0.05) between urban and rural cancer patients in terms of oral health behaviors, including brushing methods, the use of fluoride toothpaste, the use of dental floss, dental caries, and bleeding gums while brushing teeth. As for oral health service utilization, there were significant differences (p &lt; 0.05) between urban and rural cancer patients on regular dental cleaning, the reasons for visiting a dental clinic, and whether they took the initiative to learn about oral health.ConclusionThe study findings suggest that cancer patients had poor oral health behaviors and limited oral health service utilization, and rural patients perform poorer than their urban counterparts. Oral health education should be provided to cancer patients to improve their oral health behaviors and oral health service utilization.
Cell-free circulating tumor RNAs in plasma as the potential prognostic biomarkers in colorectal cancer
Authors: Jin Nana , Kan Chau-Ming , Pei Xiao Meng , Cheung Wing Lam , Ng Simon Siu Man , Wong Heong Ting , Cheng Hennie Yuk-Lin , Leung Wing Wa , Wong Yee Ni , Tsang Hin Fung , Chan Amanda Kit Ching , Wong Yin Kwan Evelyn , Cho William Chi Shing , Chan John Kwok Cheung , Tai William Chi Shing , Chan Ting-Fung , Wong Sze Chuen Cesar , Yim Aldrin Kay-Yuen , Yu Allen Chi-Shing 
Published: April 2023

BackgroundCell free RNA (cfRNA) contains transcript fragments from multiple cell types, making it useful for cancer detection in clinical settings. However, the pathophysiological origins of cfRNAs in plasma from colorectal cancer (CRC) patients remain unclear.MethodsTo identify the tissue-specific contributions of cfRNAs transcriptomic profile, we used a published single-cell transcriptomics profile to deconvolute cell type abundance among paired plasma samples from CRC patients who underwent tumor-ablative surgery. We further validated the differentially expressed cfRNAs in 5 pairs of CRC tumor samples and adjacent tissue samples as well as 3 additional CRC tumor samples using RNA-sequencing.ResultsThe transcriptomic component from intestinal secretory cells was significantly decreased in the in-house post-surgical cfRNA. The HPGD, PACS1, and TDP2 expression was consistent across cfRNA and tissue samples. Using the Cancer Genome Atlas (TCGA) CRC datasets, we were able to classify the patients into two groups with significantly different survival outcomes.ConclusionsThe three-gene signature holds promise in applying minimal residual disease (MRD) testing, which involves profiling remnants of cancer cells after or during treatment. Biomarkers identified in the present study need to be validated in a larger cohort of samples in order to ascertain their possible use in early diagnosis of CRC.