bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elemental pollution status of different components of Ologe Lagoon, Lagos, Nigeria
Authors: Oyedeji Abdulrasaq Olalekan , Sanusi Mary Pinpinlade , Azeez Luqmon Adeyemi , Ayedun Hassan 
Published: May 2023

Abstract
This study evaluated the concentrations and distributions of nutrient and non-nutrient elements in water, sediment, mud, and vegetation of Ologe Lagoon, Lagos, Nigeria. Nutrient elements including Na, Ca, K, and Mg were found in high concentration values in the different components of the freshwater ecosystem. While the water had the least concentration of the elements, Trapa natans had the highest. Aluminium showed similar distribution patterns in the different components, except for T. natans. All the samples correlated significantly with water (p &lt;0.05). Both the sediment and mud showed low potential ecological risk indexes of 5.3 and 5.92, respectively. Copper had the highest ecological risk with respect to single regulator indexes in the mud and sediment, notwithstanding its low concentration in the two components. Pollution indices suggested the low severity of non-nutrient elemental contamination of water, sediment, mud, and vegetation of Ologe Lagoon, and therefore, it is safe for human consumption, but not for agricultural irrigation. Pistia stratiotes and T. natans showed potentiality for use as photo-stabilisers and phytoremediators for some of the elements. The presence of radionuclides and rare earth elements in the components of Ologe Lagoon are instructive for specific policy initiatives to mitigate their effects on the population.
Neuroprotective Properties of Antiepileptics: What are the Implications
for Psychiatric Disorders?
Authors: Dell'Osso Liliana , Nardi Benedetta , Massoni Leonardo , Gravina Davide , Benedetti Francesca , Cremone Ivan Mirko , Carpita Barbara 
Published: May 2023

Abstract:
Since the discovery of the first antiepileptic compound, increasing attention has
been paid to antiepileptic drugs (AEDs), and recently, with the understanding of the molecular
mechanism underlying cells death, a new interest has revolved around a potential
neuroprotective effect of AEDs. While many neurobiological studies in this field have focused
on the protection of neurons, growing data are reporting how exposure to AEDs can
also affect glial cells and the plastic response underlying recovery; however, demonstrating
the neuroprotective abilities of AEDs remains a changeling task. The present work
aims to summarize and review the literature available on the neuroprotective properties of
the most commonly used AEDs. Results highlighted how further studies should investigate
the link between AEDs and neuroprotective properties; while many studies are available
on valproate, results for other AEDs are very limited and the majority of the research
has been carried out on animal models. Moreover, a better understanding of the biological
basis underlying neuro-regenerative defects may pave the way for the investigation of further
therapeutic targets and eventually lead to an improvement in the actual treatment
strategies.
Design, Docking, Synthesis, and In vitro Evaluation of Potent Anti-tubercular Agents Targeting DNA Gyrase
Authors: Bhosale Manjiri D. , Thomas Asha B. , Lokhande Kiran B. , Swamy Kakumani V. , Basu Soumya , Chitlange Sohan S. 
Published: May 2023

Background:
Tuberculosis caused by Mycobacterium tuberculosis has been reported to infect
about two-third of the global population and to continuously develop multidrug resistance. DNA gyrase, a
type II topoisomerase, is a promising target of the quinolone class of drugs in the treatment of tuberculosis.

Objective:
The present study is focused on the design and synthesis of newer nitrogen heterocyclics containing
indole, n-methyl piperazine, piperidine, and pyrrolidine ring structures.

Methods:
Initially designed compounds were evaluated for their affinity to the DNA gyrase target. The
molecular docking performed using FlexX indicated compounds IIb5 (1-(R)-(4-hydroxyphenyl)(4-
methylpiperazin-1-yl)methyl)-3-((S)-(4-hydroxyphenyl)(4-methylpiperazin-1-yl)methyl)urea and IIc5
((1-(R)-(4-hydroxyphenyl)(4-methylpiperazin-1-yl)methyl)-3-((S)-(4-hydroxyphenyl)(4-methylpiperazin-
1-yl)methyl) thiourea to exhibit promising binding affinity (dock score of -15.01 and -13.77) respectively
when compared to the reference MFX moxifloxacin (dock score -4.40) with the target 5BS8 (DNA gyrase).
Further, the best 10 compounds were synthesized by one-pot synthesis employing the reaction of
indole/N-methyl piperazine/piperidine/pyrrolidine with N-substituted benzaldehydes in the presence of
acetamide/urea/thiourea to afford the compounds in 54.60% to 85.47% yield. The synthesized compounds
were suitably characterized using chromatographic and spectroscopic tools.

Results:
In the microplate Alamar Blue assay (MABA), compounds IIb1, IIIc2, IIIb1, and IIb5 exhibited
good minimum inhibitory concentrations of 1.6 μg/mL, 3.12 μg/mL, and 12.5 μg/mL, respectively, when
compared to the standard rifampicin with 0.8 μg/mL inhibitory concentration. The MTB gyrase supercoiling
assay performed using Mycobacterium tuberculosis gyrase supercoiling assay kit demonstrated compound
IIb5 at a concentration of 300 μg/mL to show gyrase inhibition in comparison to MFX at 60
μg/mL. In the MTT assay performed using the human breast cancer cell line MCF-7, compounds IIc2,
IIb5, and IIb1 showed IC50 values of 2.57 μM, 12.54 μM, and 12.75 μM, respectively, compared to doxorubicin
(1.10 μM) at 7-48 hrs and 72 hrs of the study.

Conclusion:
Based on these observations, N-methyl piperazine class of compounds can serve as a
lead/pharmacophore for the rational design of potent molecules against MTB gyrase to combat the growing
issue of MDR-TB.
Screening of Selected Cultivars of Sweet Sorghum for Phytochemicals and In vitro Evaluation of Their Antihyperglycemic and Cytotoxic Activity
Authors: Kurella Sirisha , Addepally Uma 
Published: May 2023

Background:Sorghum, a wonder millet, is well known for its beneficial phytochemical profiles. In comparative terms, juice from sweet sorghum has better commercial potential as syrup in several food-based applications. Various sweet sorghum differs in their profile of various phytochemicals, which can impact the commercial potential of sweet sorghum juice.Methods:Our previous works on cultivars developed at ICAR-IIMR were screened for phytochemical, sugar and mineral profile. To give a holistic view of the phytochemical profile of sweet sorghum varieties, the present study is attempted to evaluate the total phenolic and flavonoid content, antihyperglycaemic and cytotoxic profile of the components present in the varieties CSV19SS, SSV84, SSV74. The phytochemical footprint of sweet sorghum juice was studied through HRLCMS.Results:The results showed ethyl acetate extract of SSV84 having potential antihyperglycemic effects with an IC50 of 22.156 ± 0.9 µg/ml (α-glucosidase) and 0.070 ± 0.02 mg/ml (α-amylase) with a comparatively higher phenolic (232.6 ± 1 mg GAE/g) and flavonoid (138.18 ± 0.9 mg QE/g) content. The chloroform extract of SSV 84 showed a higher cytotoxic effect at an IC50 of 165.502 ± 7 µg/ml (HeLa cells) and 237.895 ± 15 µg/ml (Hep G2 cells). HRLCMS profile of SSV 84 showed the presence of long-chain fatty acids in hexane extract. Anthraquinones, carotenoids, xanthophylls, cinnamic acid and derivatives, and isoflavones were present in chloroform extract, while Ethyl acetate extract was rich in phenolic acids and also consisted of coumarins, quinones, alkaloids, and terpenoids.Conclusion:The high cytotoxic and antihyperglycemic activities of extracts can be attributed to the presence of these phytochemicals.
Prediction of Cancer Driver Genes through Integrated Analysis of Differentially
Expressed Genes at the Individual Level
Authors: Gao Bo , Zhao Yue , Li Guojun 
Published: May 2023

Introduction:
It is expected that certain driver mutations may alter the gene expression of their associated or interacting partners, including cognate proteins.

Methods:
We introduced DEGdriver, a novel method that can discriminate between mutations in drivers and passengers by utilizing gene differential expression at the individual level.

Results:
After being tested on eleven TCGA cancer datasets, DEGdriver substantially outperformed cutting-edge approaches in distinguishing driver genes from passengers and exhibited robustness to varying parameters and protein-protein interaction networks.

Conclusion:
Through enrichment analysis, we prove that DEGdriver can identify functional modules or pathways in addition to novel driver genes.
Science Teacher Education Considering the Covid-19 Pandemic: The African Account
Authors: Badmus Olalekan Taofeek , Amuda Afees Akanni , Akanbi Abdulrasaq Oladimeji , Omosewo Esther Ore 
Published: May 2023

The outbreak of Covid-19 the world over is devastating. The responses to the disruptions experienced had left many nations in doubt of a possible recovery in years to come. Various sectors of human needs were distorted, and the socioeconomic impact cannot be overestimated. The education sector is one of the first sectors to be locked down immediately after the emergence of the pandemic and about the last to be recalled after the first wave of Covid-19. Education institutions are experiencing massive reforms globally amid the Covid-19 outbreak and the effect of the lockdown is enormous. The economic impact of the pandemic is more pronounced than the academic, especially in science and science teacher education. This paper investigated science teacher education considering the Covid-19 pandemic. Specifically, this research explored the African account of Covid-19, the effect of Covid-19 on science teacher education, the rationale for a rethink in science teacher education amidst Covid-19, the limitations to science teacher education post-Covid-19 and the way forward for stakeholders amid/post Covid-19. This article concluded among others that more is required in terms of investment in the education sector to actualize the modern approaches required to cope with the pandemic situations in Africa.
Pengetahuan Parsial: Representasi Guru pada Relasi dan Fungsi
Authors: Nisak Dzikiyan Khairiyatun , Nusantara Toto 
Published: May 2023

Pengetahuan representasi merupakan indikator pengetahuan matematis guru sebagai salah satu tolok ukur profesionalitas guru. Tujuan studi kasus ini untuk mengetahui kemampuan representasi guru pada relasi dan fungsi. Studi kasus ini menggunakan pendekatan kualitatif. Studi kasus ini dilakukan pada 6 subjek penelitian (kategori H (High), M (Midle), L(Low), dan VL (Very Low)) yang dipilih dari 314 peserta UKG Kabupaten Blitar tahun 2015. Hasil tes dapat dikelompokkan menjadi 3 kelompok. Studi kasus ini menunjukkan bahwa pengetahuan representasi geometris guru masih kurang. Pemahaman relasi dan fungsi masih bersifat parsial. Temuan lainnya adalah bahwa pengetahuan matematis dipengaruhi oleh konsistensi penerapannya, kemauan untuk terus memperdalam ilmu matematika, pengetahuan siswa yang dapat memicu kreativitas guru untuk menemukan cara efektif agar siswa bisa memahami materi. Sedangkan untuk kemampuan representasi pada suatu materi , dapat dilatih melalui pembiasaan menyatakan relasi dan fungsi dalam bentuk aljabar, geometris, tabel, maupun diagram.
Perancangan Perangkat Makan Bersama Bertolak dari Tradisi Bajamba Minangkabau Menggunakan Metode Ekstraksi Unsur Visual
Authors: Raisa Shofia  , Aulia Wildan 
Published: May 2023

Abstract—Bajamba is one of the communal dining activities in Indonesia from the Minangkabau tradition. The article views that the uniqueness of the Minangkabau Bajamba tradition can be applied to more contemporary tableware sets. This study aims to design a contemporary tableware set using ceramic materials by emphasizing the application of the visual elements of traditional trays and cloth covers of Minangkabau. The number of people, as well as the types and the number of menus in the Bajamba meal, are the main references for the tableware set design. The decision on the dimensions, shape, and concept of the tableware set refers to the Bajamba tradition of dining. This study offers a tableware set design consisting of a tray with a diameter of 50 cm, four small plates, and four plates of curry sauce. The comprehensive prototyping test results show that the process of making a tray requires a plate with a diameter of approximately 55 cm, so it requires a large drying furnace. This design offers its uniqueness inspired by the Bajamba tradition which can provide a different and enjoyable dining experience. In addition, its use can help preserve the Bajamba Minangkabau tradition through the use of tableware sets inspired by this tradition.
Keywords: bajamba, tableware set, communal dining, tradition, minangkabau

Abstrak—Bajamba merupakan salah satu tradisi makan bersama di Indonesia yang berasal dari Minangkabau. Artikel ini memandang bahwa keunikan tradisi bajamba Minangkabau dapat diterapkan kepada perancangan perangkat makan bersama yang lebih masa kini. Perancangan ini bertujuan untuk menghasilkan desain set perangkat makan bersama dari bahan keramik dengan menekankan pada terapan unsur visual dulang dan dalamak tradisional Minangkabau. Jumlah kumpul orang, serta jenis dan jumlah menu dalam sajian Bajamba menjadi referensi utama dalam memutuskan desain. Keputusan dimensi, bentuk dan konsep perangkat makan mengacu pada aktivitas makan tradisi bajamba. Perancangan ini menghasilkan satu set perangkat makan bersama yang terdiri dari satu dulang berdiameter 50 cm, empat piring kecil, dan empat piring kuah gulai. Hasil uji coba purwarupa menunjukkan bahwa proses membuat dulang memerlukan plat berdiameter kurang lebih 55 cm sehingga memerlukan tungku pengering yang besar. Desain ini menawarkan keunggulan berupa keunikan tersendiri yang terinspirasi dari tradisi Bajamba yang dapat memberikan pengalaman makan yang berbeda dan menyenangkan. Selain itu, penggunaannya dapat membantu melestarikan tradisi Bajamba Minangkabau melalui penggunaan perangkat makan yang terinspirasi dari tradisi tersebut.
Kata kunci: bajamba, perangkat makan, makan bersama, tradisi, minangkabau
MATEMATIK EĞITIMI LISANSÜSTÜ ARAŞTIRMALARDAN YANSIMALAR
Authors: ALA Aslı Merve , SAFA Süleyman , KANBOLAT Oben 
Published: May 2023

ÖZ: Araştırmanın amacı, matematik eğitimi alanında Türkiye’de yayımlanan lisansüstü tez çalışmalarının genel eğilimini betimlemek için gerçekleştirilmiştir. Ulusal tez merkezi veri tabanı aracılığıyla matematik eğitimi anabilim dalında eğitim konulu 102 adet lisansüstü tez yayımlanma yılına, türlerüne, yöntemsel özelliklerine ve anahtar kelimelerine göre betimsel içerik analizi yapılmıştır.
Yapılan analizler neticesinde, matematik eğitimi anabilim dalında eğitim konulu ilk tezin 2003 yılında yayımlanan bir doktora tezi olduğu; yıllar içerisinde yayımlanan tezlerin büyük oranda yüksek lisans tezi olduğu tespit edilmiştir. Bunun yanında tezlerde tercih edilen araştırma yaklaşımlarına göre dağılımlar incelendiğinde, yüksek lisans ve doktora tezlerinin her ikisinde de nitel yaklaşımın çoğunlukla tercih edildiği; tezlerde tercih edilen araştırma deseni bağlamında ise deneysel desenin tercih edildiği görülmüştür. Matematik eğitiminde yayımlanan tezlerde en fazla araştırma yaklaşımına dair anahtar kelimelerin kullanıldığı ve bunu sırasıyla öğrenme alanı, genel, bilişsel beceriler, yöntemle ilgili nadiren de ölçme ve değerlendirme, matematiksel dil, duyuşsal beceriler, etnomatematik, matematik okuryazarlığı ve öğretmen yetiştirmeye dair anahtar kelimelerin kullanıldığı ifade edilebilir. Araştırma kapsamında incelenen bazı tezlerde araştırma yaklaşımı, deseni, çalışma grubu türü, büyüklüğü ve veri toplama aracına ilişkin bilgiye rastlanılmamıştır. Tezlerde özellikle yöntem bölümünde olan eksiklikler okuyucunun araştırma sürecini tam anlamıyla zihninde tasavvur etmesi zorlaşmaktadır. Bu bağlamda tez yazarlarının araştırmalarını raporlaştırırken bu hususlarda dikkatli olması önerilmektedir.
Horse serum or equine platelet lysate increases total vascular endothelial growth factor A concentrations and correlates with vascular growth in an equine facial arterial ring assay
Authors: Mora-Pereira Mariano , Boone Lindsey , Naskou Maria , Wooldridge Anne 
Published: May 2023

Abstract

OBJECTIVE
To evaluate ex vivo angiogenesis of equine arterial rings in response to various growth media.

ANIMALS
Facial arteries were dissected from 11 horses post-euthanasia. Equine platelet lysate (ePL) was harvested from 6 horses.

PROCEDURES
Arteries were exposed to endothelial growth media (EGM) + horse serum (HS) for first sprout (FS), vascular regression (VR), and (basement membrane matrix [Matrigel]) lysis (ML) evaluation. Additional rings supplemented with (1) EGM, (2) EGM + EDTA, (3) endothelial basal media (EBM), (4) EBM + HS, or (5) EBM + human VEGF were compared for vascular network area (VNA) and maximum network growth (MNG). Additional rings exposed to EGM + ePL at 10-(10xePL), 5-(5xePL), or 2-fold (2xePL) increases from baseline platelet concentration, EGM + HS, EGM + platelet-poor plasma (PPP), EBM + PPP and EBM were analyzed for branch number, density, VNA, and VEGF-A concentration from days 0–3.

RESULTS
Arteries demonstrated sprouting in Matrigel supplemented with EBM alone. EGM + HS exposure resulted in no differences in FS (P = .3934), VR (P = .0607), or ML (P = .2364) between horses. VNA in EGM + HS was greater than EBM (P = .0015). MNG was greater in EGM + HS, EBM + HS, and EBM + hVEGF compared with EBM (P = .0001). ePL treatment did not have an overall significant angiogenic effect compared with supplementation with HS, PPP, or EBM alone; however, VEGF-A concentrations were higher for EGM + 10xePL, EGM + 5xePL, and EGM-HS compared with EBM and positively correlated with VNA (P = .0243).

CLINICAL RELEVANCE
Equine arterial rings serve as an ex vivo model for angiogenesis but have a high degree of variability. HS, PPP, or ePL support vascular growth, and HS and ePL may stimulate the secretion and be sources of VEGF-A.
Application development on Brassica species in aquaculture – a review
Authors: Vijayaram Srirengaraj , Razafindralambo Hary , Sun Yun-Zhang , Ghafarifarsani Hamed , Hoseinifar Seyed Hossein , Raeeszadeh Mahdieh , Doan Hien Van 
Published: May 2023

Abstract

Brassicaceae family are traditional, medicinal and nutritional value plants. Brassicaceae family produces valuable components to provide different types of beneficial effects for humans and animals such as anti-oxidant, antimicrobial, anticancer, anti-scurvy, anti-inflammatory, anti-hyperglycemic, anti-tumor, anti-diabetes, anti-stomach diseases, and anti-cardiac. This review mainly focuses to observe Brassicaceae family response in aquatic animals and provides some information collected from literature analysis regarding the development of aquaculture applications like Brassicaceae family plants used as a supplement to enhance nutritional value, replacement of fish meal, antimicrobial activity against pathogens, immunomodulatory effects, antioxidant, and growth activity of aquatic animals. This literature review analysis is helpful to enlighten for future research and development on the application in the aquaculture sector.
Evaluation of Distillers Dried Grains With Solubles in Aquafeeds – A Review
Authors: Ragab Sherine , Hoseinifar Seyed Hossein , Doan Hien Van , El-Haroun Ehab 
Published: May 2023

Abstract
The aquafeed industry faces many challenges, including reducing the cost of feed by reducing the quantity of fish meal and soybean meal and researching to replace them with other ingredients lower in cost. Furthermore, new low-cost feeds must improve growth and feed utilization while also ensuring fish health. During the past few decades, researchers have shown one of the low-cost and with appropriate nutritional value alternative protein sources to replace fish meal (FM) or soybean meal (SBM) is dried distillers grains with solubles (DDGS). Recently, the production of grain-based ethanol as a fuel additive has been increasing as the demand for biofuel has increased, and lessening dependency on fossil fuels has resulted in a dramatic rise in the amount of grains used for ethanol. DDGS are the primary co-product of dry-grind fuel ethanol plants. DDGS has the advantages of having high protein, fat, phosphorus, yield, and low cost. These valuable particles attributed to DDGS have raised controversy amongst feed nutritionists as to how they can proficiently replace fish meal or soybean meal. It has been discovered that DDGS can be replaced with fish meal or soybean meal without affecting growth. Therefore, the present review discusses the effects of dietary DDGS application in the fish feed formulation, the best dietary presence, the possible advantages in fish health, nutrient retention, and the economic benefits of DDGS application in aquafeeds.
Effects of dietary Lactobacillus helveticus ATC 15009 on growth performance, hematology parameters, innate immune responses, and the antioxidant status of rainbow trout (Oncorhynchus mykiss) under high rearing density
Authors: Jasim Saade Abdalkareem , Altalbawy Farag M.A. , Alameri Ameer A. , Ramírez-Coronel Andrés Alexis , Obaid Rasha Fadhel , Al-Hamdani Mais Mazin , Kadhim Abed J. , Zabibah Rahman S. , Alzahrani Hayat Ali , Farsani Sadegh Ghafari , Dadras Mahnaz 
Published: May 2023

Abstract
This study aimed to evaluate the effects of dietary probiotic supplementation of Lactobacillus helveticus on growth, digestive enzymes, and hematological, biochemical, immune, and antioxidant parameters, as well as intestinal microbiota of rainbow trout (Oncorhynchus mykiss). Fish (35.46±0.9 g) were fed with different levels of dietary L. helveticus: control, 1 × 106, 1 × 107, 1 × 108, and 1 × 109 at high stocking density (80 kg m−3) for 60 days. Results indicated that growth performance significantly improved in probiotic supplemented fish (P<0.05). Digestive enzyme parameters revealed that supplementation could significantly increase amylase, protease, and lipase (P<0.05). The treated groups showed significant improvements in serum immune parameters including lysozyme (LYZ), alternative complement (ACH50), respiratory burst activity (RBA), and myeloperoxidase (MPO) (P<0.05). Total protein (TP), albumin (ALB), and globulin (GLO) increased in fish fed experimental diets (P<0.05). Lactate dehydrogenase (LDH) activity was significantly lower in fish fed dietary additives (P<0.05) while white blood cells (WBC), lymphocytes, neutrophils, hematocrit (Hct), red blood cells (RBC) were significantly enhanced (P<0.05). Fish fed with supplemented diets showed significantly enhanced antioxidant status, catalase (CAT) and superoxide dismutase (SOD). Malondialdehyde (MDA) content was significantly lower in fish fed dietary additives (P<0.05). Lactic acid bacteria (LAB) in the treatment groups were significantly increased (P<0.05). In conclusion, dietary supplementation of L. helveticus reduced detrimental effects of high stocking density on growth performance and immune response. It appears that L. helveticus can be recommended as a beneficial probiotic feed additive for rainbow trout.