bluuebunny/crossref_metadata_2025_split huggingface dataset:
APOE2 Exacerbates TDP‐43 Related Toxicity in the Absence of Alzheimer Pathology
Authors: Meneses Axel D. , Koga Shunsuke , Li Zonghua , O'Leary Justin , Li Fuyao , Chen Kai , Murakami Aya , Qiao Wenhui , Kurti Aishe , Heckman Michael G. , White Launia , Xie Manling , Chen Yixing , Finch Nicole A. , Lim Melina J. , Delenclos Marion , DeTure Michael A. , Linares Cynthia , Martin Nicholas B. , Ikezu Tadafumi C. , van Blitterswijk Marka M. , Wu Long‐Jun , McLean Pamela J. , Rademakers Rosa , Ross Owen A. , Dickson Dennis W. , Bu Guojun , Zhao Na 
Published: December 2022

ObjectiveRecent evidence supports a link between increased TDP‐43 burden and the presence of an APOE4 gene allele in Alzheimer's disease (AD); however, it is difficult to conclude the direct effect of APOE on TDP‐43 pathology due to the presence of mixed AD pathologies. The goal of this study is to address how APOE isoforms impact TDP‐43 pathology and related neurodegeneration in the absence of typical AD pathologies.MethodsWe overexpressed human TDP‐43 via viral transduction in humanized APOE2, APOE3, APOE4 mice, and murine Apoe‐knockout (Apoe‐KO) mice. Behavior tests were performed across ages. Animals were harvested at 11 months of age and TDP‐43 overexpression‐related neurodegeneration and gliosis were assessed. To further address the human relevance, we analyzed the association of APOE with TDP‐43 pathology in 160 postmortem brains from autopsy‐confirmed amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with motor neuron disease (FTLD‐MND) in the Mayo Clinic Brain Bank.ResultsWe found that TDP‐43 overexpression induced motor function deficits, neuronal loss, and gliosis in the motor cortex, especially in APOE2 mice, with much milder or absent effects in APOE3, APOE4, or Apoe‐KO mice. In the motor cortex of the ALS and FTLD‐MND postmortem human brains, we found that the APOE2 allele was associated with more severe TDP‐43‐positive dystrophic neurites.InterpretationOur data suggest a genotype‐specific effect of APOE on TDP‐43 proteinopathy and neurodegeneration in the absence of AD pathology, with the strongest association seen with APOE2. ANN NEUROL 2023;93:830–843
Unprecedented Relaxivity Gap in pH‐Responsive FeIII‐Based MRI Probes
Authors: Salaam Jeremy , Fogeron Thibault , Pilet Guillaume , Bolbos Radu , Bucher Christophe , Khrouz Lhoussain , Hasserodt Jens 
Published: December 2022

AbstractTwo mononuclear ferric complexes are reported that respond to a pH change with a 27‐ and 71‐fold jump, respectively, in their capacity to accelerate the longitudinal relaxation rate of water‐hydrogen nuclei, and this starting from a negligible base value of only 0.06. This unprecedented performance bodes well for tackling the sensitivity issues hampering the development of Molecular MRI. The two chelates also excel in the fully reversible and fatigue‐less nature of this phenomenon. The structural reasons for this performance reside in the macrocyclic nature of the hexa‐dentate ligand, as well as the presence of a single pendant arm displaying a five‐membered lactam or carbamate which show (perturbed) pKa values of 3.5 in the context of this N6
N5O1 coordination motif.
Ion‐selectivity of polypyrrole carbide‐derived carbon films in aqueous electrolytes
Authors: Le Quoc Bao , Zondaka Zane , Nguyen Ngoc Tuan , Kiefer Rudolf 
Published: December 2022

AbstractIn this work, we have combined polypyrrole (PPy) doped with dodecylbenzene sulfonate (DBS−) and carbide‐derived carbon (CDC), forming PPyCDC (PPy/DBS‐CDC) composites. Scanning electron microscopy revealed for PPyCDC that most CDC particles are located on the surface of the films. This work's main goal is to investigate the ion‐selectivity of the novel PPyCDC composite by linear actuation studies, with primary actuation taking place at discharging. Four different aqueous electrolytes are applied with hydrophobic cations, such as TMA+ (tetramethylammonium ion) and EDMI+ (1‐ethyl‐2,3‐dimethyl imidazolium ion). They are hydrophilic with Li+ (lithium‐ion) and Na+ (sodium ion). It was possible to distinguish each cation from linear actuation studies, either cyclic voltammetry or square wave potential steps. In the case of pristine PPy/DBS, that ion differentiation could not separate. Chronopotentiometric measurements of both films (PPyCDC and PPy/DBS) were performed. It could control (read) the strain for PPyCDC films and the potential at constant current density. The electrical energy adapts to exchange cations, forming a sensor device with ion‐selectivity of the applied cations considering their hydrophilic and hydrophobic characteristics. The best specific capacitance (energy storage) is found for EDMI+ cations in PPyCDC films with 193 F g−1, enabling this composite in multifunctional applications.
Notable Catalytic Activity of Transition Metal Thiolate Complexes against Hydrosilylation and Hydroboration of Carbon‐Heteroatom Bonds
Authors: Fang Fei , Zhang Jie 
Published: December 2022

AbstractChemists tend to use transition metal hydride complexes rather than thiolate complexes to catalyse chemical transformations because the hydride complexes possess diverse catalytic reactivity, although most of them are air/moisture‐sensitive and difficult to prepare. By comparing the catalytic performances of pincer ligated group 10 metal thiolate and hydride complexes in catalysing the hydroboration and hydrosilylation of C=O and C=N bonds, we demonstrate in this review that transition metal thiolate complexes are much better catalysts than the corresponding hydride complexes in catalysing this type of reactions. Many hydroboration and hydrosilylation reactions catalysed by pincer ligated group 10 metal hydride complexes can also be catalysed by the corresponding thiolate complexes and the thiolate systems are far more active. Therefore, the applications of transition metal thiolate complexes in the catalytic hydroboration and hydrosilylation of unsaturated carbon‐heteroatom bonds deserve special attention in future work.
The impact of autism spectrum disorder on parent employment: Results from the r‐Kids study
Authors: Lynch Frances L. , Bulkley Joanna E. , Varga Alexandra , Crawford Phillip , Croen Lisa A. , Daida Yihe G. , Fombonne Eric , Hatch Brigit , Massolo Maria , Dickerson John F. 
Published: December 2022

AbstractParents of children with autism spectrum disorder (ASD) and other chronic health conditions often face exceptional caregiving demands that can lead to challenges related to maintaining and succeeding in employment. Detailed information on the specific ways in which these health conditions impact parent employment could aid in designing equitable, effective policies to support families. The r‐Kids study used electronic health records to identify three groups of children: those with ASD, asthma, or neither condition (control), from several health care systems. We oversampled racial and ethnic minorities and matched the asthma and control groups to the age and sex distribution of the ASD group. Parents completed three online surveys over the course of a year to measure annual employment outcomes. Surveys included the Family Economic Impact Inventory (measuring employment impacts) and measures of quality of life and symptom severity. All materials were provided in English and Spanish. The study enrolled 1461 families (564 ASD, 468 asthma, 429 control). Youth were 3–16.5 years old and predominantly male (79%). The sample was diverse (43% non‐Hispanic White; 35% non‐Hispanic Asian, Black, Native Hawaiian, or Other; and 21% Hispanic ethnicity). Parents of children with ASD were significantly less likely to be employed than parents of youth with asthma and control combined (OR: 14.2, p < 0.001), and were more likely to have other difficulties with employment and productivity while at work. Public and employer policies to help mitigate these impacts could aid families in managing care for youth with ASD.
Illustration of Capacity Fading Factors on the Example of La2(Li0.5Ni0.5)O4‐Modified High Nickel Layered Oxide Material
Authors: Ivanishcheva Irina A. , Ivanishchev Aleksandr V. , Chang Joon Ha , Song Jung‐Hoon , Lee Su‐Hyun , Kim Jae‐Joong , Kim Young Je , Nam Sang‐Cheol 
Published: December 2022

AbstractModifying of layered oxide NCM (LiNi0.85Co0.1Mn0.05O2) with high nickel (Ni) content is a popular strategy for development of energy‐dense cathode materials for LIBs. In spite of long‐time investigations of their electrochemical performance there is no clear understanding of the predominant capacity fading reasons as well as the mechanism of suppression of performance degradation for modified samples. In the present work, NCM (bare and washed) powders were modified by perovskite‐like phase La2(Li0.5Ni0.5)O4 (LNP), using lithium residual compounds (LRC) from NCM surface. Initial properties of NCM‐materials were under our focus in terms of structural data of pristine powders and the first cycle capacity loss. We observed that incomplete lithium extraction in case of LNP‐modified NCM bare sample preserves electrochemical performance. For illustration of the main reasons of capacity fading new type Δ‐plots were proposed. Based on their analysis we highlighted two factors, affecting on capacity retention. Our conclusions were supported by D vs. E dependence analysis from GITT measurements.
Theoretical study of a downdraft gasifier, microturbine, and organic Rankine cycle fuelled by date molasses waste for distributed generation applications in Iraq
Authors: Malik Abbas Safaa , Dakhel Alhassany Hend , Vera David , Jurado Francisco 
Published: December 2022

AbstractThe main objective of this work is the modeling of a combined heat and power (CHP) system that transforms waste from manufacturing date molasses in the Babylon province in central Iraq into electrical and thermal energy. A compact CHP facility that uses date waste (pomace and pits) as a feedstock is the subject of theoretical modeling and simulation research. The planned power plant consists of a downdraft gasifier, a microturbine (MT), and an organic Rankine cycle engine (ORC) as a bottom unit to maximize electric generation by recovering the MT exhaust gas heat and achieving a maximum electric output. The net electric production is 361.68 kW (280 kW from the MT unit and 81.68 kW from the ORC unit). To determine the best‐working fluid for the ORC system as a whole, three working fluids, including isopentane, benzene, and R113, were investigated. The temperature difference between the heat source and the fluid's boiling point is a key factor in choosing a more appropriate ORC working fluid. Isopentane is the most suitable working fluid for CHP applications, according to the findings of the simulation. The electric efficiency achieved is 30%, and the overall efficiency of the CHP plant was 56.87% from the gasification of date pits. The simulation results showed a satisfactory producer gas lower calorific value of 3.92 MJ k‐g‐1 for date pomace and 4.65 MJ k‐g‐1 for date pits, and cold gasification efficiencies of 73% and 76% for pomace and pits, respectively. © 2023 Society of Industrial Chemistry and John Wiley & Sons Ltd.
Biological sex is binary, even though there is a rainbow of sex roles
Authors: Goymann Wolfgang , Brumm Henrik , Kappeler Peter M. 
Published: December 2022

AbstractBiomedical and social scientists are increasingly calling the biological sex into question, arguing that sex is a graded spectrum rather than a binary trait. Leading science journals have been adopting this relativist view, thereby opposing fundamental biological facts. While we fully endorse efforts to create a more inclusive environment for gender‐diverse people, this does not require denying biological sex. On the contrary, the rejection of biological sex seems to be based on a lack of knowledge about evolution and it champions species chauvinism, inasmuch as it imposes human identity notions on millions of other species. We argue that the biological definition of the sexes remains central to recognising the diversity of life. Humans with their unique combination of biological sex and gender are different from non‐human animals and plants in this respect. Denying the concept of biological sex, for whatever cause, ultimately erodes scientific progress and may open the flood gates to “alternative truths.”
Detection of the freshness of rice by chemiluminescence
Authors: Li Li , Zhang Yuchong , Gu Yuxi , Shan Xiaoxue , Fu Aihua , Yang Juan , Xiong Shengwei , Liu Xiaoli , Chen Chao , Yang Yehong , Wang Jin , Yang Chao , Lan Xueping , Jiang Youjun , He Linhong , Chen Jinying 
Published: December 2022

AbstractReactive oxygen species (ROS) are usually produced in rice under aerobic environmental conditions, resulting in peroxidative changes in polyunsaturated fatty acids, and affecting the deterioration of rice during storage. In addition, as an important enzyme that participates in removing ROS, peroxidase is also present in rice, and takes part in protecting rice from attack by ROS. Moreover, loss of peroxidase activity may give rise to rice deterioration during storage. Therefore, measuring peroxidase activity makes it possible to ascertain the freshness of rice. In addition, peroxidase can also catalyze the luminol–hydrogen peroxide system. Based on this, in this work we established a new chemiluminescence (CL) method that was used to detect the freshness of stored rice. Under optimal experimental conditions, we showed that the freshness of rice can be measured using this CL method. This study is the first to detect the freshness of rice using a CL method, opening up a novel direction for the application of CL.
Prosthetic vascular grafts engineered to combat calcification: Progress and future directions
Authors: Brown Taylor K. , Alharbi Sara , Ho Karen J. , Jiang Bin 
Published: December 2022

AbstractCalcification in prosthetic vascular conduits is a major challenge in cardiac and vascular surgery that compromises the long‐term performance of these devices. Significant research efforts have been made to understand the etiology of calcification in the cardiovascular system and to combat calcification in various cardiovascular devices. Novel biomaterial design and tissue engineering strategies have shown promise in preventing or delaying calcification in prosthetic vascular grafts. In this review, we highlight recent advancements in the development of acellular prosthetic vascular grafts with preclinical success in attenuating calcification through advanced biomaterial design. We also discuss the mechanisms of action involved in the designs that will contribute to the further understanding of cardiovascular calcification. Lastly, recent insights into the etiology of vascular calcification will guide the design of future prosthetic vascular grafts with greater potential for translational success.
Sustainable clothing: Why conspicuous consumption and greenwashing matter
Authors: Apaolaza Vanessa , Policarpo Manoela Costa , Hartmann Patrick , Paredes Mario R. , D'Souza Clare 
Published: December 2022

AbstractThis study analyzes the degree to which conspicuous consumption motives, environmental concern, perceived consumer effectiveness, trust in sustainable clothing brands, and perceived greenwashing trigger the purchase of sustainable clothing. The theoretical framework was tested with a representative online sample of the Australian population (N = 600). Results showed that all proposed antecedents have a positive relationship with the purchase of sustainable clothing, with the exception of perceived greenwashing, which decreases purchase intention. In addition, perceived consumer effectiveness positively moderated the effect of conspicuous consumption motives on purchasing. Conspicuous consumption motives had a stronger effect on purchase when perceived effectiveness was high, and this influence was reduced for lower perceived effectiveness. The interaction between conspicuous consumption and perceived efficacy had the strongest effect in the model. Our findings highlight the relevance of conspicuous consumption as a motive for switching to sustainable clothing and the likewise important role of perceived consumer effectiveness, which is a boundary condition for this effect. Findings also confirm the significant positive influence of environmental concern and trust in the sustainable clothing brand, while perceived greenwashing is a barrier to the adoption of sustainable clothing. Theoretical and practical implications of the findings are discussed.
Mindfulness and psychological distress in men during the COVID‐19 pandemic: The mediating role of environmental mastery and purpose in life
Authors: Palma Emanuel Missias Silva , Reis de Sousa Anderson , Aguiar Carolina Villa Nova , Nilo Nathali Guimarães , dos Santos Tácio Matos 
Published: December 2022

AbstractMen's mental health has been severely affected during the COVID‐19 pandemic, with many studies focussing on the determinants of men's psychological distress. This study aimed at examining the relationships between mindfulness, environmental mastery (EM), purpose in life (PL) and indicators of psychological distress (i.e., common mental disorders and perceived stress). This was a cross‐sectional online study in which participants were 1,006 men aged between 29 and 39 years (45.1%), residing in Brazil during the first wave of the COVID‐19 pandemic. A parallel multiple mediator model was used to test the study variables' relationships, using mindfulness as the independent variable and indicators of psychological distress as the dependent variables. Results indicated that EM and PL significantly mediated the effects of mindfulness on men's psychological distress, lowering its levels and accounting for 31% of common mental disorders and 51% of perceived stress. Implications for public health policies and clinical practice are discussed.
Substrate Specificity of the Highly Thermostable Esterase EstDZ3
Authors: Papanikolaou Angelos , Chatzikonstantinou Alexandra V. , Zarafeta Dimitra , Kourkoumelis Nikolaos , Skretas Georgios , Pavlidis Ιoannis V. , Stamatis Haralambos 
Published: December 2022

AbstractEsterases are among the most studied enzymes, and their applications expand into several branches of industrial biotechnology. Yet, despite the fact that information on their substrate specificity is crucial for selecting or designing the best fitted biocatalyst for the desired application, it cannot be predicted from their amino acid sequence. In this work, we studied the substrate scope of the newly discovered hydrolytic extremozyme, EstDZ3, against a library of esters with variable carbon chain lengths in an effort to understand the crucial amino acids for the substrate selectivity of this enzyme. EstDZ3 appears to be active against a wide range of esters with high selectivity towards medium‐ to long‐carbon chain vinyl esters. In‐silico studies of its 3D structure revealed that the selectivity might arise from the mainly hydrophobic nature of the active site's environment.
The First Alkaline‐Earth Azidoaurate(III), Ba[Au(N3)4]2 ⋅ 4 H2O
Authors: Subaşı Yaprak , Tekin Elif Sena , Prots Yurii , Jach Franziska , Somer Mehmet , Afyon Semih , Höhn Peter 
Published: December 2022

AbstractTransparent, dark orange Ba[Au(N3)4]2 ⋅ 4 H2O was synthesized by reaction of Ba(N3)2 and AuCl3 or HAuCl4 in aqueous solution. The novel barium tetraazidoaurate(III) tetrahydrate crystallizes in the monoclinic space group Cc (no. 9) with a=1813.68(17) pm, b=1737.95(11) pm, c=682.04(8) pm and β=108.849(4)°. The predominant structural features of Ba[Au(N3)4]2 ⋅ 4 H2O are two crystallographically independent discrete anions [Au(N3)4]− with gold in a tetragonal planar coordination by nitrogen. Vibrational spectra show good agreement with those of other azidoaurates(III). Upon drying, this salt was shown to be a highly explosive material.
Mechanistic Insights into the Metal‐Free Deoxygenative Borylation of Ketones and Aldehydes with Bis(catecholato)diborane
Authors: Zou Wentian , Yang Mo , He Linke , Gao Liuzhou , Wang Guoqiang , Li Shuhua 
Published: December 2022

AbstractThe mechanisms of direct deoxygenative borylation of acetone and benzaldehyde with bis(catecholato)diborane (B2cat2) in the solvent N,N‐dimethylacetamide (DMA) are investigated through detailed density functional theory calculations. These calculations show that the isomer 1,2‐B2cat2 in situ generated from 1,1‐B2cat2 induced by DMA is the reactive boron intermediate for the reactions. The addition of the B−B bond of 1,2‐B2cat2 to the C=O bond of acetone or benzaldehyde via a concerted [2σ+2π]‐cycloaddition‐like transition state is the rate‐limiting step for both the triboration reaction of acetone and the monoboration reaction of benzaldehyde. DMA not only acts as the solvent but also promotes the structural isomerization of B2cat2, the deoxygenation of acetone to form the vinyl boronate intermediate and subsequent diboration of vinyl boronate with 1,2‐B2cat2, as well as the protodeboronation of the gem‐diboronate intermediate in the deoxygenative borylation of benzaldehyde. The presented computational results can explain the observed experimental facts and provide insight into the roles of the isomeric 1,2‐B2cat2 and the solvent DMA in related reactions.
Thermoresponse of Odd‐Even Effect in n‐Alkanethiolate Self‐Assembled Monolayers on Gold Substrates**
Authors: Park Sohyun , Kim Eunchan , Choi Youngjin , Jang Jiung , Kwak Kyungwon , Cho Minhaeng , Yoon Hyo Jae 
Published: December 2022

AbstractThis study examines thermoresponse of odd‐even effect in self‐assembled monolayers (SAMs) of n‐alkanethiolates (SCn, n=3–18) formed on template‐stripped gold (AuTS) using macro‐ and microscopic analytical techniques, contact angle goniometry (CAG) and vibrational sum frequency generation (VSFG) spectroscopy, respectively. Both CAG and VSFG analyses showed that the odd‐even effect in liquid‐like SAMs (n=3–9) disappeared upon heating at 50–70 °C, indicating that the heating led to increased structural disorder regardless of odd and even carbon numbers. In contrast, the opposite thermoresponse was observed for odd and even SCn molecules in wax‐ and solid‐like SAMs (n=10–18). Namely, temperature‐dependent orientational change of terminal CH3 relative to the surface normal was opposite for the odd and even molecules, thereby leading to mitigated odd‐even effect. Our work offers important insights into thermoresponse of supramolecular structure in condensed organic matter.
Highly Efficient and Stable Blue OLEDs Based on B—N Bonds Embedded 6,12‐Diphenyl‐5,11‐dihydroindolo[3,2‐b]carbazole with Narrowband Emission and Extended Lifetime†
Authors: Dai Hengyi , Zhou Jianping , Meng Guoyun , Wang Lu , Duan Lian , Zhang Dongdong 
Published: December 2022

Comprehensive SummaryEmitters with narrowband spectra are of great importance nowadays because of the growing demand for ultra‐high‐definition displays in the fields of panel displays and solid‐state lighting. Though the reported multiple resonance (MR) emitters have been widely studied with extremely sharp spectra and color‐tunable emissions, the electrophilic borylation synthetic strategies and stable narrowband blue devices still face great challenges. Herein, by virtue of the advantages of both the MR effect of conventional indolocarbazole skeleton and the easy‐to‐access of B—N covalent bonds, the linear tert‐butyl benzene and carbazole groups modified 6,12‐diphenyl‐5,11‐dihydroindolo[3,2‐b]carbazole derivatives (tPh[BN] and Cz[BN]) containing two B—N covalent bonds are easily constructed through amine‐directed double borylation strategy. Both emitters behaved bright blue emission with full‐width‐at‐half‐maximum (FWHM) of 20—27 nm in solution, high fluorescence quantum efficiency over 90%, and excellent stability toward moisture. By employing triplet‐triplet annihilation electroluminescent mechanism, blue OLED devices based on them showed a small FWHM of 48 nm and maximum external quantum efficiency of ~7.1% with negligible efficiency roll‐off, and long operational lifetime (LT80) of 87 h at an initial brightness of 1000 cd·m−2, demonstrating the enormous application potential of B—N bonds embedded emitters in achieving ideal narrowband blue emitters.