bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of peer-delivered physical activity promotion and maintenance programs for initially sedentary breast cancer survivors
Authors: Chen Brian K , Dunsiger Shira I , Pinto Bernardine M 
Published: May 2023

Abstract
The evidence for the survival and health benefits of physical activity (PA) among cancer survivors is well documented. However, it has been challenging to maintain PA among cancer survivors. To evaluate the cost-effectiveness of peer support to encourage maintenance of moderate-to-vigorous physical activity (MVPA) among breast cancer survivors. Participants were randomized into Reach Plus Message (weekly text/email messages), Reach Plus Phone (monthly phone calls) or Reach Plus (a self-monitoring intervention) over 6 months after an initial adoption phase. We calculated the incremental cost-effectiveness ratios (ICER) in terms of quality-adjusted years life years (QALYs) and self-reported MVPA, from the payer’s budgetary and societal perspectives over 1 year. Intervention costs were collected via time logs from the trainers and peer coaches, and participant costs from the participants via surveys. For our sensitivity analyses, we bootstrapped costs and effects to construct cost-effectiveness planes and acceptability curves. The intervention that provides weekly messages from peer coaches has an ICER of $14,446 per QALY gained and $0.95 per extra minute of MVPA per day over Reach Plus. Reach Plus Message has a 49.8% and 78.5% probability of cost-effectiveness respectively when decision makers are willing to pay approximately $25,000 per QALY and $10 per additional minute of MVPA. Reach Plus Phone, which requires tailored monthly telephone calls, costs more than Reach Plus Message but yields less QALY and self-reported MVPA at 1 year. Reach Plus Message may be a viable and cost-effective intervention strategy to maintain MVPA among breast cancer survivors.
A Mixed-Method Pilot Project
Authors: Hamilton William , Walters Colleen , Howington Zackery 
Published: May 2023

Abstract
Telehealth has become ubiquitous, and advanced practice nurses will need to be proficient in its use. Recent literature has shown that graduate nursing curricula may not fully prepare students for clinical telehealth practice. This article describes an interactive, module-based course that was built using instructional design principles for the training of graduate nursing students to prepare them to conduct telehealth encounters. The course was proven to be efficacious based on pre-post test results and critical reflections. The blueprint described can be used by nurse educators and administrators to prepare nurses to provide safe and effective telehealth services.
Attributable Perioperative Cost of Frailty after Major, Elective Noncardiac Surgery: A Population-based Cohort Study
Authors: McGinn Ryan , Agung Yonathan , Grudzinski Alexa L. , Talarico Robert , Hallet Julie , McIsaac Daniel I. 
Published: May 2023

Background
Patients with frailty consistently experience higher rates of perioperative morbidity and mortality; however, costs attributable to frailty remain poorly defined. This study sought to identify older patients with and without frailty using a validated, multidimensional frailty index and estimated the attributable costs in the year after major, elective noncardiac surgery.

Methods
The authors conducted a retrospective population-based cohort study of all patients 66 yr or older having major, elective noncardiac surgery between April 1, 2012, and March 31, 2018, using linked health data obtained from an independent research institute (ICES) in Ontario, Canada. All data were collected using standard methods from the date of surgery to the end of 1-yr follow-up. The presence or absence of preoperative frailty was determined using a multidimensional frailty index. The primary outcome was total health system costs in the year after surgery using a validated patient-level costing method capturing direct and indirect costs. Secondary outcomes included costs to postoperative days 30 and 90 along with sensitivity analyses and evaluation of effect modifiers.

Results
Of 171,576 patients, 23,219 (13.5%) were identified with preoperative frailty. Unadjusted costs were higher among patients with frailty (ratio of means 1.79, 95% CI 1.76 to 1.83). After adjusting for confounders, an absolute cost increase of $11,828 Canadian dollar (ratio of means 1.53; 95% CI, 1.51 to 1.56) was attributable to frailty. This association was attenuated with additional control for comorbidities (ratio of means 1.24, 95% CI, 1.22 to 1.26). Among contributors to total costs, frailty was most strongly associated with increased postacute care costs.

Conclusions
For patients with preoperative frailty having elective surgery, the authors estimate that attributable costs are increased 1.5-fold in the year after major, elective noncardiac surgery. These data inform resource allocation for patients with frailty.

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An evaluation of the methodological quality of published guidelines for the surgical treatment of pleural mesothelioma
Authors: Bertolaccini Luca , Bardoni Claudia , Maffeis Gabriele , Mohamed Shehab , Prisciandaro Elena , Diotti Cristina , Casiraghi Monica , Petrella Francesco , Spaggiari Lorenzo 
Published: May 2023

Background
To benchmark their quality, a project was designed to analyze the methodology of previous guidelines and recommendations for malignant pleural mesothelioma projects.

Methods
A narrative literature search was conducted, and each guideline was evaluated using the Appraisal of Guidelines for Research and Evaluation (AGREE) II tool and rated on a seven-point scale for its many items and domains.

Results
Six guidelines that met the inclusion requirements were evaluated. Due to greater development rigor and editorial independence, the engagement of scientific societies was associated with an improvement in methodological quality.

Conclusion
According to the standards of AGREE II, the methodological quality of earlier guidelines was relatively low. Nonetheless, two previously published guidelines could serve as a template for the establishment of the most effective methodological quality guidelines.
Indocyanine green angiography of type 1 macular neovascularization in age-related macular degeneration and central serous chorioretinopathy reveals different disease mechanisms.
Authors: Zola Marta , Bousquet Elodie , Favard Catherine , Gigon Anthony , Mantel Irmela , Behar-Cohen Francine 
Published: May 2023

Abstract

Purpose:
To assess the rate of late phase hyperfluorescent plaque (LPHP) in type 1 macular neovascularization (MNV) in CSCR (central serous chorioretinopathy) and AMD (age-related macular degeneration) and to evaluate its prognostic value.

Methods:
Retrospective study including type 1 MNV in AMD and CSCR, from 2012 to 2020. Eyes with a late ICG-A image (>20mins) and clear visualization of MNV on OCTA were included. Quantitative and qualitative parameters on OCT and best corrected visual acuity were recorded at baseline, and after 3 monthly anti-VEGF injections.

Results:
Eighty-three eyes were included, 35 with CSCR and 48 with AMD. Patients in the CSCR group were significantly younger than in the AMD group (61.3 ± 10.4 vs. 80.2 ± 6.8 years respectively, p<0.001), predominantly male (68.6% CSCR vs 35.4% AMD; p=0.003) and with a thicker choroid (379 ± 93.3 μm vs 204.2 ± 93.2 μm; p<0.001). Type 1 MNV in CSCR showed fewer LPHP compared to AMD (31.4% vs 77.1%; p<0.001). Baseline visual acuity was lower in patients with LPHP (0.37± 0.22 vs 0.27 ±0.28 LogMAR, p=0.03). On multivariate analysis, AMD was associated with the presence of LPHP (p<0.001). No significant difference in the response to anti-VEGF was observed.

Conclusion:
Leakage of macromolecules from MNV and accumulation in the RPE and/or in the stroma imaged by the LPHP is less common in eyes with type 1 MNV in CSCR than in AMD. Late phase ICG-A imaging offers an insight into the metabolism of the dye and the environment surrounding the neovascular membrane.
Calcinosis Cutis and Calciphylaxis Mimicking Skin Infection
Authors: Chan Patrick , Greene John N. 
Published: May 2023

Abstract
Calcinosis cutis refers to the deposition of calcium salts into the skin or subcutaneous tissue, and when these calcium deposits involve the vasculature, it is known as calciphylaxis (http://www.ncbi.nlm.nih.gov/books/NBK448127/). These conditions can both mimic and predispose patients to infections; thus, diagnoses may be confused between the two. We present 3 cases involving cutaneous wounds due to calcium deposition and discuss their infectious considerations. The first case is a 74-year-old male patient with myeloid sarcoma and B-cell acute lymphoblastic leukemia who was evaluated for calciphylaxis of the bilateral lower extremities. The second case is a 70-year-old female patient with a history of squamous cell carcinoma with subsequent surgical resection and radiation therapy of the right elbow who presented with right elbow cellulitis. The third case is a 68-year-old male patient with a history of myositis ossificans and multiple surgical excisions of calcium deposits who presented with a draining wound of the left upper extremity.
A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses
Authors: Li Song , Brimmers Annika , van Boekel Regina L.M. , Vissers Kris C.P. , Coenen Marieke J.H. 
Published: May 2023

AbstractPain is the leading cause of disability worldwide, imposing an enormous burden on personal health and society. Pain is a multifactorial and multidimensional problem. Currently, there is (some) evidence that genetic factors could partially explain individual susceptibility to pain and interpersonal differences in pain treatment response. To better understand the underlying genetic mechanisms of pain, we systematically reviewed and summarized genome-wide association studies (GWASes) investigating the associations between genetic variants and pain/pain-related phenotypes in humans. We reviewed 57 full-text articles and identified 30 loci reported in more than 1 study. To check whether genes described in this review are associated with (other) pain phenotypes, we searched 2 pain genetic databases, Human Pain Genetics Database and Mouse Pain Genetics Database. Six GWAS-identified genes/loci were also reported in those databases, mainly involved in neurological functions and inflammation. These findings demonstrate an important contribution of genetic factors to the risk of pain and pain-related phenotypes. However, replication studies with consistent phenotype definitions and sufficient statistical power are required to validate these pain-associated genes further. Our review also highlights the need for bioinformatic tools to elucidate the function of identified genes/loci. We believe that a better understanding of the genetic background of pain will shed light on the underlying biological mechanisms of pain and benefit patients by improving the clinical management of pain.
Learning curves in laparoscopic distal pancreatectomy: a different experience for each generation
Authors: van Ramshorst Tess M.E. , Edwin Bjørn , Han Ho-Seong , Nakamura Masafumi , Yoon Yoo-Seok , Ohtsuka Takao , Tholfsen Tore , Besselink Marc G. , Abu Hilal Mohammad 
Published: May 2023

Background:
Learning curves of laparoscopic distal pancreatectomy (LDP) are mostly based on ‘self-taught’ surgeons who acquired sufficient proficiency largely through self-teaching. No learning curves have been investigated for ‘trained’ surgeons who received training and built on the experience of the ‘self-taught’ surgeons. This study compared the learning curves and outcome of LDP between ‘self-taught’ and ‘trained’ surgeons in terms of feasibility and proficiency using short-term outcomes.

Materials and methods:
Data of consecutive patients with benign or malignant disease of the left pancreas who underwent LDP by four ‘self-taught’ and four ‘trained’ surgeons between 1997 and 2019 were collected, starting from the first patient operated by a contributing surgeon. Risk-adjusted cumulative sum (RA-CUSUM) analyses were performed to determine phase-1 feasibility (operative time) and phase-2 proficiency (major complications) learning curves. Outcomes were compared based on the inflection points of the learning curves.

Results:
The inflection points for the feasibility and proficiency learning curves were 24 and 36 procedures for ‘trained’ surgeons compared to 64 and 85 procedures for ‘self-taught’ surgeons, respectively. In ‘trained’ surgeons, operative time was reduced after completion of the learning curves (230.5–203 min, P=0.028). In ‘self-taught’ surgeons, operative time (240–195 min, P≤0.001), major complications (20.6–7.8%, P=0.008), and length of hospital stay (9–5 days, P≤0.001) reduced after completion of the learning curves.

Conclusion:
This retrospective international cohort study showed that the feasibility and proficiency learning curves for LDP of ‘trained’ surgeons were at least halved as compared to ‘self-taught’ surgeons.
A novel F8 variant in a Chinese hemophilia A family and involvement of X-chromosome inactivation: A case report
Authors: Zhang Honghong , Li Yinjie , Lv Xiaojuan , Mao Yuchan , Sun Yixi , Xu Ting 
Published: May 2023

Rationale:
Hemophilia A (HA) is an X-linked recessive bleeding disorder, which shows factor VIII (FVIII) deficiency caused by genetic variant in F8 gene.

Patient concerns:
Males with F8 variants are affected, whereas female carriers with a wide range of FVIII levels are usually asymptomatic, it is possible that different X-chromosome inactivation (XCI) may effect the FVIII activity.

Diagnoses:
We identified a novel variant F8: c.6193T > G in a Chinese HA proband, it was inherited from the mother and grandmother with different FVIII levels.

Interventions:
We performed Androgen receptor gene (AR) assays and RT-PCR.

Outcomes:
AR assays revealed that the X chromosome with the F8 variant was severely skewed inactivated in the grandmother with higher FVIII levels, but not in the mother with lower FVIII levels. Further, RT-PCR of mRNA confirmed that only the wild allele of F8 was expressed in the grandmother, with lower expression in the wild allele of the mother.

Lessons:
Our findings suggest that F8: c.6193T > G could be the cause of HA and that XCI affected the FVIII plasma levels in female carriers.
PADI4 and IL-33 gene polymorphisms with susceptibility to systemic lupus erythematosus and juvenile idiopathic arthritis, a systematic review and meta-analysis
Authors: Zheng Bo , Cai Pingping , Chen Yangjun , Wu Yuechao , Liu Hongyan 
Published: May 2023

Background:
This study evaluated the association between peptidyl arginine deiminase type IV (PADI4) and interleukin 33 (IL-33) with systemic lupus erythematosus (SLE) and juvenile idiopathic arthritis (JIA).

Method:
We searched the PubMed, Web of Science, Embase and Cochrane Library databases to retrieve articles published up to January 20, 2023. Stata/SE 17.0 (College Station, TX) software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The cohort study, case-control study focusing on the PADI4, IL-33 polymorphism, and SLE, JIA were retrieved. The data included basic information of each study and the genotypes and allele frequencies.

Results:
Studies in PADI4 rs2240340 = 2 and 3 IL-33(rs1891385 = 3, rs10975498 = 2, rs1929992 = 4) were found in 6 articles. Overall, only the IL-33 rs1891385 show significant association between SLE in all 5 models. The results were OR (95% CI) = 1.528 (1.312, 1.778), P = .000 in Allele model (C vs A), OR (95% CI) =1.473 (1.092, 1.988), P = .000 in Dominant model (CC + CA vs AA), 2.302 (1.583, 3.349), P = .000 in Recessive model (CC vs CA + AA), 2.711 (1.845, 3.983), P = .000 in Homozygote model (CC vs AA), 5.568 (3.943, 7.863), P = .000 in Heterozygote model (CA vs AA). PADI4 rs2240340, IL-33 rs10975498, IL-33 rs1929992 were not found to be association with the risk of SLE and JIA. In gene model, statistically significant association was found between IL-33 rs1891385 and SLE in sensitivity analysis. Egger’s publication bias plot showed there was no publication bias (P = .165). Only in recessive model the heterogeneity test was significant (I
2 = 57.9%, P ≤ .093) of IL-33 rs1891385.

Conclusion:
The current study suggests that in all 5 model, IL-33 rs1891385 polymorphism may be associated with genetic susceptibility to SLE. There was unclear association found between PADI4 rs2240340, IL-33 rs10975498, and IL-33 rs1929992 polymorphisms and SLE and JIA. Due to the limitations of included studies and the risk of heterogeneity, additional research is required to confirm our findings.

PROSPERO registration number:
CRD42023391268.
Primary bacterial intercostal pyomyositis diagnosis: A case report
Authors: Toyoshima Hirokazu , Tanigawa Motoaki , Ishiguro Chiaki , Tanaka Hiroyuki , Nakanishi Yuki , Sakabe Shigetoshi , Hisatsune Junzo , Kutsuno Shoko , Iwao Yasuhisa , Sugai Motoyuki 
Published: May 2023

Rationale:
Pyomyositis is a microbial infection of the muscles and contributes to local abscess formation. Staphylococcus aureus frequently causes pyomyositis; however, transient bacteremia hinders positive blood cultures and needle aspiration does not yield pus, especially at the early disease stage. Therefore, identifying the pathogen is challenging, even if bacterial pyomyositis is suspected. Herein, we report a case of primary pyomyositis in an immunocompetent individual, with the identification of S aureus by repeated blood cultures.

Patient concerns:
A 21-year-old healthy man presented with fever and pain from the left chest to the shoulder during motion. Physical examination revealed tenderness in the left chest wall that was focused on the subclavicular area. Ultrasonography showed soft tissue thickening around the intercostal muscles, and magnetic resonance imaging with short-tau inversion recovery showed hyperintensity at the same site. Oral nonsteroidal anti-inflammatory drugs for suspected virus-induced epidemic myalgia did not improve the patient’s symptoms. Repeated blood cultures on days 0 and 8 were sterile. In contrast, inflammation of the soft tissue around the intercostal muscle was extended on ultrasonography.

Diagnoses:
The blood culture on day 15 was positive, revealing methicillin-susceptible S aureus JARB-OU2579 isolates, and the patient was treated with intravenous cefazolin.

Interventions:
Computed tomography-guided needle aspiration from the soft tissue around the intercostal muscle without abscess formation was performed on day 17, and the culture revealed the same clone of S aureus.

Outcomes:
The patient was diagnosed with S aureus-induced primary intercostal pyomyositis and was successfully treated with intravenous cefazolin for 2 weeks followed by oral cephalexin for 6 weeks.

Lessons:
The pyomyositis-causing pathogen can be identified by repeated blood cultures even when pyomyositis is non-purulent but suspected based on physical examination, ultrasonography, and magnetic resonance imaging findings.
Strategies for expanding patient and public involvement into under-served head and neck cancer communities
Authors: Lawton Michelle , Crane Julie , Killen Vince , Patterson J. M. 
Published: May 2023

Purpose of review
In this review, we discuss two case studies in which we summarize the process of expanding patient and public involvement (PPI) representation specific to the head and neck cancer population, highlighting the challenges and successes within each project. The first case study reports on the expansion of HaNC PPI membership, a long-established PPI forum which supports Liverpool Head and Neck Centre research. The second case study describes the establishment of a novel palliative care network in head and neck cancer in the North of England, in which PPI was central to the project's success.

Recent findings
Whilst recognizing diversity is important, it is imperative to acknowledge the contribution of existing members. Engagement with clinicians to reduce issues of gatekeeping is essential. A central theme is that the development of sustainable relationships is critical.

Summary
The case studies highlight the challenge of identifying and accessing such a diverse population, particularly in the context of palliative care. Successful PPI is dependent on building and maintaining relationship with PPI members, ensuring flexibility in terms of timing, platforms and venues. Relationships formation should not be restricted to the academic-PPI representative dyad but should consider both clinical-academic and community partnerships to ensure those who are part of under-served communities are afforded the opportunities to become involved in research.
Assessing Pain in Older Adults
Authors: Horgas Ann L. , Bruckenthal Patricia , Chen Shaoshuai , Herr Keela A. , Young Heather M. , Fishman Scott 
Published: May 2023

This article is part of a series, Supporting Family Caregivers: No Longer Home Alone, published in collaboration with the AARP Public Policy Institute. Results of focus groups, conducted as part of the AARP Public Policy Institute's No Longer Home Alone video project, supported evidence that family caregivers aren't given the information they need to manage the complex care regimens of family members. This series of articles and accompanying videos aims to help nurses provide caregivers with the tools they need to manage their family member's health care at home.
This new group of articles provides practical information nurses can share with family caregivers of persons living with pain. To use this series, nurses should read the articles first, so they understand how best to help family caregivers. Then they can refer caregivers to the informational tear sheet—Information for Family Caregivers—and instructional videos, encouraging them to ask questions. For additional information, see Resources for Nurses. Cite this article as: Horgas, A.L., et al. Assessing Pain in Older Adults. Am J Nurs 2022; 122 (12): 42-48.
Targeted Muscle Reinnervation
Authors: Henderson Joshua T. , Koenig Zachary A. , Climov Mihail , Gelman Jack 
Published: May 2023

Introduction/BackgroundDespite inspiring improvements in postamputation pain and prosthetic control, targeted muscle reinnervation (TMR) continues to be underused. With some consistency for recommended nerve transfers developing in the literature, it is necessary to systematize these techniques and simplify their incorporation into routine amputation and neuroma care. This systematic review explores the coaptations reported in the literature to date.MethodsA systematic review of the literature was performed to collect all reports describing nerve transfers in the upper extremity. The preference was directed toward original studies presenting surgical techniques and coaptations used in TMR. All target muscle options were presented for each nerve transfer in the upper extremity.ResultsTwenty-one original studies describing TMR nerve transfers throughout the upper extremity met inclusion criteria. A comprehensive list of transfers reported for major peripheral nerves at each upper extremity amputation level was included in tables. Ideal nerve transfers were suggested based on convenience and frequency with which certain coaptations were reported.ConclusionsIncreasingly frequent studies are published with convincing outcomes with TMR and numerous options for nerve transfers and target muscles. It is prudent to appraise these options to provide patients with optimal outcomes. Certain muscles are more consistently targeted and can serve as a baseline plan for the reconstructive surgeon interested in incorporating these techniques.