bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis by Gender and Race and Ethnicity of Reviewers and Awardees for Intramural Research Funding in the Veterans Health Administration
Authors: Boyer Taylor L. , Essien Utibe R. , Litam Terrence M. A. , Hausmann Leslie R. M. , Suda Katie J. 
Published: January 2023

ImportanceUnderrepresentation of women and racial and ethnic minority individuals among reviewers and funded investigators in health research has been widely reported. It is unknown whether such underrepresentation exists in the Veterans Health Administration (VHA).ObjectiveTo describe gender and racial and ethnic makeup of VHA Health Services Research and Development (HSR&amp;amp;D) study sections and funding awardees and to explore the associations between gender and racial and ethnic makeup of study sections and awardees who were women and racial and ethnic minority individuals.Design, Setting, and ParticipantsThis cross-sectional study at the VHA evaluated study section members and funding awardees from 5 review cycles from March 13, 2018, through March 6, 2020, identified via the HSR&amp;amp;D and National Institutes of Health websites.Main Outcomes and MeasuresUnivariable and multivariable logistic regression models were used to determine the likelihood of an awardee being a woman or a racial or ethnic minority individual based on the gender and racial and ethnic makeup of study sections, respectively. Separate models were conducted for investigator-initiated research proposals only.ResultsThirty-six study sections comprised 664 reviewers, including 381 women (57.4%) and 81 racial and ethnic minority individuals (12.2%). Of the 146 funded proposals, 77 (52.7%) were awarded to women and 25 (17.1%) to racial and ethnic minority investigators; 29 (19.9%) were reviewed by study sections with no racial and ethnic minority reviewers. The odds of a woman awardee were more than 5 times greater for proposals reviewed by study sections comprising the highest proportion of women (fourth quartile; &amp;gt;58.3%) than the lowest proportion of women (first quartile; ≤50.0%) (adjusted odds ratio [aOR], 5.24 [95% CI, 1.70-16.13]). Similarly, the odds of a racial or ethnic minority awardee were 3 times greater for proposals reviewed by study sections in the top 50th percentile for proportion of racial and ethnic minority individuals (&amp;gt;7.3%) than the bottom 50th percentile (aOR, 3.08 [95% CI, 1.18-8.09]). Secondary analyses limited to investigator-initiated research proposals identified similar associations.Conclusions and RelevanceIn this cross-sectional study of VHA HSR&amp;amp;D-funded research, racial and ethnic minority individuals were underrepresented among investigators and reviewers. More women and racial and ethnic minority reviewers on study sections were associated with women and racial and ethnic minority individuals awarded funding.
Dim Light at Night Promotes Circadian Disruption in Female Rats, at the Metabolic, Reproductive, and Behavioral Level
Authors: Gutiérrez‐Pérez Mariana , González‐González Shellye , Estrada‐Rodriguez Karla P. , Espítia‐Bautista Estefania , Guzmán‐Ruiz Mara A. , Escalona Rene , Escobar Carolina , Guerrero‐Vargas Natalí N. 
Published: January 2023

AbstractInhabitants of urban areas are constantly exposed to light at night, which is an important environmental factor leading to circadian disruption. Streetlights filtering light through the windows and night dim light lamps are common sources of dim light at night (DLAN). The female population is susceptible to circadian disruption. The present study is aimed to determine the impact of DLAN on female Wistar rats circadian rhythms, metabolism, reproductive physiology, and behavior. After 5 weeks of DLAN exposure daily, oscillations in activity and body temperature of female rats are abolished. DLAN also decreases nocturnal food ingestion, which results in a diminishment in total food consumption. These alterations in the temporal organization of the body are associated with a significant decrease in melatonin plasmatic levels, reproductive disruptions, decreased exploration times, and marked anhedonia. This study highlights the importance of avoiding exposure to light at night, even at low intensities, to maintain the circadian organization of physiology, and denotes the great necessity of increasing the studies in females since the sexual dimorphism within the effects of desynchronizing protocols has been poorly studied.
Green Synthesis of Liquid Metal‐Doped Carbon Dots for Treating Multidrug‐Resistant Gram‐Negative Bacteria
Authors: Bi Shunchao , Hang Chen , Qi Jie , Zhang Wei , Jiang Xingyu 
Published: January 2023

AbstractGlobal emergence of multidrug‐resistant (MDR) gram‐negative bacteria triggers severe infections that result in an epidemic. It is urgent to discover novel classes of antibacterial agents. Here, a green route for synthesizing polyethylene glycol‐based carbon dots (PEG‐CDs) doped with liquid metal (LM‐Cdots) via a solvent‐free system is presented. LM‐Cdots synthesized via ultrasound exhibit great antibacterial activity against gram‐negative bacteria (E. coli, P. aeruginosa, K. pneumoniae, and A. baumannii) and their multidrug‐resistant (MDR) clinical isolates. In the in vitro antibacterial test with MDR K. pneumoniae, LM‐Cdots show an extremely low minimum inhibition concentration (MIC) of 0.63 µg mL−1. Compared to naked PEG‐CDs, the MIC is improved by 1000 times. In vivo results reveal that LM‐Cdots can accelerate wound healing with low biotoxicity and inflammation.
Triple Interface Optimization of Ru‐based Electrocatalyst with Enhanced Activity and Stability for Hydrogen Evolution Reaction
Authors: Li Guozheng , Sun Tong , Niu Hua‐Jie , Yan Yu , Liu Tong , Jiang Sisi , Yang Qinglin , Zhou Wei , Guo Lin 
Published: January 2023

AbstractA challenging task is to promote Ru atom economy and simultaneously alleviate Ru dissolution during the hydrogen evolution reaction (HER) process. Herein, Ru nanograins (≈1.7 nm in size) uniformly grown on 1T‐MoS2 lace‐decorated Ti3C2Tx MXene sheets (Ru@1T‐MoS2‐MXene) are successfully synthesized with three types of interfaces (Ru/MoS2, Ru/MXene, and MoS2/MXene). It gives high mass activity of 0.79 mA µgRu−1 at an overpotential of 100 mV, which is ≈36 times that of Ru NPs. It also has a much smaller Ru dissolution rate (9 ng h−1), accounting for 22% of the rate for Ru NPs. Electrochemical tests, scanning electrochemical microscopy measurements combined with DFT calculations disclose the role of triple interface optimization in improved activity and stability. First, 2D MoS2 and MXene can well disperse and stabilize Ru grains, giving larger electrochemical active area. Then, Ru/MoS2 interfaces weakening H* adsorption energy and Ru/MXene interfaces enhancing electrical conductivity, can efficiently improve the activity. Next, MoS2/MXene interfaces can protect MXene sheet edges from oxidation and keep 1T‐MoS2 phase stability during the long‐term catalytic process. Meanwhile, Ru@1T‐MoS2‐MXene also displays superior activity and stability in neutral and alkaline media. This work provides a multiple‐interface optimization route to develop high‐efficiency and durable pH‐universal Ru‐based HER electrocatalysts.
Nucleic Acids Enabled‐Interfacial Engineering for Biomarker Sensing with Distance Constraint Effects
Authors: Wang Lu , Tang Shuqi , Li Lin , Jin Kaifei , Xie Xiyue , Chen Yuhua , Cai Kaiyong , Zhang Jixi 
Published: January 2023

AbstractControlling the distance of molecular recognition and signal transduction at the nano–bio interface plays a vital role in sensing molecular interactions, which significantly impacts how a biomarker sensor performs in terms of sensitivity, specificity, detection threshold, and response time. However, conventional biosensing interfaces without the design of distance constraint show limited molecular interactions, hindering target accessibility and mass transport. Nuclei acid‐enabled engineering of biosensing interfaces facilitates highly regulated orientation and programmable density control of biomolecules, providing an effective strategy to improve the performance of biosensing platforms for early diagnosis of diseases and regulation of cellular activities. This review summarizes the recent advances in nucleic acid‐based engineering of biosensing interfaces from a unique perspective of distance constraint effects. The roles of structural nucleic acids in delicately programmed assemblies, functional nucleic acids in molecular recognition, and sensor reactions at well‐controlled distances are highlighted. Then applications of advanced biosensing platforms with the effect of distance constraint are introduced. Finally, the current challenges and future directions for developing such biosensors that can compete effectively to meet the requirements of point‐of‐care testing are also discussed.
Diagnostic features of low‐ and high‐grade mucinous neoplasms in pancreatic cyst FNA cytology
Authors: Sigel Carlie , Wei Xiao‐Jun , Agaram Narasimhan , Sigel Keith , Raza Roshan , Andrade Rebecca , Rao Rema , Shah Pari , Soares Kevin , Goyal Abha 
Published: January 2023

AbstractBackgroundPancreatic cyst cytology evaluates for neoplastic mucin and epithelial grade. This study describes cytological features of low‐ and high‐grade mucinous neoplasms (MNs) using gastrointestinal contaminants for comparison.MethodsHistologically confirmed pancreatic cystic neoplasms were reviewed by a panel of cytopathologists to identify which, among 26 selected cytologic features, correlate significantly with low‐ and high‐grade MN. A test for greater than or equal to four of eight high‐grade features (three‐dimensional architecture, high nuclear:cytoplasmic ratio, moderate nuclear membrane abnormalities, loss of nuclear polarity, hyperchromasia, >4:1 nuclear size variation in one cluster, karyorrhexis, and necrosis) was assessed for identifying a high‐grade neoplasms. Additional characteristics of the cohort such as cyst fluid carcinoembryonic antigen results, molecular testing, Papanicolaou Society of Cytopathology classification, and select high‐risk clinical features are described.ResultsEndoscopic ultrasound fine‐needle aspirations from 134 MN and 17 serous cystadenomas containing gastrointestinal contaminants were included. The MN consisted of 112 (84%) intraductal papillary MNs (low‐grade = 69, 62%; high‐grade = 24, 21%; and invasive = 19, 17%) and mucinous cystic neoplasms (low‐grade = 20, 90%; high‐grade = 2, 10%). Half had greater than five clusters of epithelium for analysis. Compared with gastrointestinal contaminants, mucin from MN was thick and colloid‐like (40% vs. 6%, p < .01), covered >20% of the smear area (32% vs. none, p < .01), and contained histiocytes (46% vs. 18%, p = .04). Greater than or equal to four of eight select high‐grade features was present in 36% of high‐grade MN with sensitivity 37% and 98% specificity.ConclusionColloid‐like features, >20% of smear, and histiocytes correlated with MN. Testing for greater than or equal to four high‐grade features had low sensitivity and high specificity for high‐grade MN.
Sigma Delta Quantization for Images
Authors: Lyu He , Wang Rongrong 
Published: January 2023

AbstractIn signal quantization, it is well‐known that introducing adaptivity to quantization schemes can improve their stability and accuracy in quantizing bandlimited signals. However, adaptive quantization has only been designed for one‐dimensional signals. The contribution of this paper is two‐fold: (i) we propose the first family of two‐dimensional adaptive quantization schemes that maintain the same mathematical and practical merits as their one‐dimensional counterparts, and (ii) we show that both the traditional 1‐dimensional and the new 2‐dimensional quantization schemes can effectively quantize signals with jump discontinuities, which immediately enable the usage of adaptive quantization on images. Under mild conditions, we show that by using adaptivity, the proposed method is able to reduce the quantization error of images from the presently best to the much smaller , where s is the number of jump discontinuities in the image and P () is the total number of samples. This ‐fold error reduction is achieved via applying a total variation norm regularized decoder, whose formulation is inspired by the mathematical super‐resolution theory in the field of compressed sensing. Compared to the super‐resolution setting, our error reduction is achieved without requiring adjacent spikes/discontinuities to be well‐separated, which ensures its broad scope of application.We numerically demonstrate the efficacy of the new scheme on medical and natural images. We observe that for images with small pixel intensity values, the new method can significantly increase image quality over the state‐of‐the‐art method. © 2022 Wiley Periodicals, Inc.
Empirical Hydrogen Bonding Donor (HBD) Parameters of Organic Solvents Using Solvatochromic Probes – A Critical Evaluation
Authors: Spange Stefan , Weiß Nadine 
Published: January 2023

AbstractThe solvatochromicity of established solvatochromic UV/Vis probes, which appear to be sensitive to the so‐called hydrogen bond donor (HBD) property of the solvent, is analysed using the hydroxyl group density of alcoholic solventsDHBDas a physical parameter in comparison to the pKa, the chemical benchmark for acidity. Reichardt's dyeB30, KosowersZ‐indicator 1‐ethyl‐4‐(methoxycarbonyl) pyridinium iodide (K), Kamlet‐Tafts α, DragosSparameter, CatalansSAscale, thecis‐dicyano‐bis (1,10‐phenanthroline) iron II complex (Schilt's Ferrocyphen dye,Fe) and Gutmann‘s acceptor number (AN) have been investigated. The observed dependencies of the empirical polarity parameters as a function ofDHBDfor several alcoholic solvent families requires a ompletely new physicochemical understanding of these established HBD parameters. Only theANscale (orFe) is able to bridge the gap between global polarity and acidity, provided the values are interpreted correctly and applied accordingly.
The global depth range of marine fishes and their genetic coverage for environmental DNA metabarcoding
Authors: Duhamet Agnès , Albouy Camille , Marques Virginie , Manel Stephanie , Mouillot David 
Published: January 2023

AbstractThe bathymetric and geographical distribution of marine species represent a key information in biodiversity conservation. Yet, deep‐sea ecosystems are among the least explored on Earth and are increasingly impacted by human activities. Environmental DNA (eDNA) metabarcoding has emerged as a promising method to study fish biodiversity but applications to the deep‐sea are still scarce. A major limitation in the application of eDNA metabarcoding is the incompleteness of species sequences available in public genetic databases which reduces the extent of detected species. This incompleteness by depth is still unknown. Here, we built the global bathymetric and geographical distribution of 10,826 actinopterygian and 960 chondrichthyan fish species. We assessed their genetic coverage by depth and by ocean for three main metabarcoding markers used in the literature: teleo and MiFish‐U/E. We also estimated the number of primer mismatches per species amplified by in silico polymerase chain reaction which influence the probability of species detection. Actinopterygians show a stronger decrease in species richness with depth than Chondrichthyans. These richness gradients are accompanied by a continuous species turnover between depths. Fish species coverage with the MiFish‐U/E markers is higher than with teleo while threatened species are more sequenced than the others. “Deep‐endemic” species, those not ascending to the shallow depth layer, are less sequenced than not threatened species. The number of primer mismatches is not higher for deep‐sea species than for shallower ones. eDNA metabarcoding is promising for species detection in the deep‐sea to better account for the 3‐dimensional structure of the ocean in marine biodiversity monitoring and conservation. However, we argue that sequencing efforts on “deep‐endemic” species are needed.
Forecasting housing investment
Authors: Cañizares Martínez Carlos , de Bondt Gabe J. , Gieseck Arne 
Published: January 2023

AbstractThis study applies a model averaging approach to conditionally forecast housing investment in the largest Euro area countries and the Euro area. To account for substantial modeling uncertainty, it estimates a large and diverse number of vector error correction models using a wide set of long‐ and short‐run determinants and applies subset selection based on in‐sample and out‐of‐sample criteria. First, a pseudo out‐of‐sample forecast exercise shows that our model averaging approach consistently beats a battery of distinguished benchmark models, including BVARs, FAVARs, LASSO, and Ridge regressions. This evidences that model averaging provides more accurate forecasts also in the case of housing investment. Second, we find remarkable cross‐country heterogeneity in the drivers of housing investment. Overall, these findings guide forecasters and modelers on improving housing investment models and policymakers on implementing country‐specific housing market policies.
Expression of MSTN/Smad signaling pathway genes and its association with meat quality in Tibetan sheep (Ovis aries)
Authors: He Na , Lang Xia , Wang Cailian , Lv Cailing , Li Mingming , Sun Ruizhe , Zhang Junxia 
Published: January 2023

AbstractTibetan sheep is a unique breed living in Qinghai‐Tibet Plateau. Since MSTN/Smad signaling pathway plays a critical role in the regulation of muscle development, we aimed to study the mutton quality, mRNA expression of main transduction genes in the MSTN/Smad signaling pathway, and the effects of those genes on the mutton quality of Tibetan sheep in this study. Six‐month‐old Qinghai‐Tibetan sheep were selected, slaughtered, and their Longissimus lumborum, semitendinosus muscle, arm triceps, and quadriceps femoris muscle were collected. The mutton quality was evaluated, and gene expression and their association with the mutton quality were analyzed using RT‐qPCR. The results showed that the indexes of mutton quality were not significantly different between ewes and rams (p > .05) except for Warner–Bratzler shear force (WBSF) (p < .05). A total of 21 different fatty acids were detected in the muscles of Tibetan sheep, including nine types of SFA, four types of MUFA, and eight types of PUFA. The main transduction genes of the MSTN/Smad signaling pathway were found to be widely expressed in muscle tissues, but no significant differences were observed (p > .05). The correlation analysis of the main genes and mutton quality showed that MSTN was significantly correlated with redness and cooking time; Smad2, Smad3, Smad4, and TGFβRI had significant positive correlations with marbling in arm triceps; Smad3 and TGFβRII had strong negative correlations with pH24 h in Longissimus lumborum; Smad2 was negatively correlated with drip loss in Longissimus lumborum. In short, the expression level of MSTN in muscles was positively correlated with Smad2, Smad3, and Smad4 genes and negatively correlated with TGFβRII genes. Thus, the results of this study provide a theoretical basis for the regulation mechanism of the MSTN/Smad pathway on mutton quality.
Looking up and fitting in: Team leaders' and members' behaviors and attitudes toward the environment in an MNC
Authors: Baldassari Paul , Eberhard Sophie , Jiang Yuan , Muller‐Camen Michael , Obereder Lisa , Schiffinger Michael , Thiele Raik 
Published: January 2023

AbstractAs an emerging topic in human resource management (HRM) research, organizational citizenship behavior for the environment (OCBE) and workgroup green advocacy (WGGA) have been studied as a proxy of the environmental performance of organizations as well as a potential way for companies to assess the impact of their environmental strategies and initiatives. Viewing OCBE and WGGA as green‐focused knowledge, skills, abilities, and other characteristics and building on leader‐member exchange theory, we examined the effects of leaders' OCBE and WGGA, person‐supervisor fit (PSF), and person‐group fit (PGF) as well as their potential interactions on members' OCBE and WGGA. To minimize the potential impact of different company strategies, the study was conducted in one MNC using a sample of 269 members from 64 teams. The results revealed that PSF and especially PGF were associated with members' OCBE and WGGA, but leaders' OCBE was a stronger predictor of members' OCBE and WGGA than leaders' WGGA. Contrary to our prediction, no moderating effect of PSF or PGF was found for the associations between leaders' and members' WGGA and OCBE. Together, these findings shed light on the differential trickle‐down effects of leaders' perceptions and behaviors in the context of environmental management. As for the implications for HRM practitioners, our findings suggest companies may focus on leaders' OCBE and WGGA as well as on PSF and PGF independently as the means to shaping team members' OCBE and WGGA to support environmental strategies.
Natural evolution and risk factors for adverse outcome in selective intrauterine growth restriction under expectant management: A retrospective observational study
Authors: Chen Lu , Zhou Weixiao , Zhang Yanhua , Zhao Wei , Wen Hong 
Published: January 2023

AbstractObjectiveTo evaluate the natural evolution of and risk factors for the adverse outcome of monochorionic twins with selective intrauterine growth restriction (sIUGR) under expectant management.MethodsRetrospective study conducted in a single tertiary referral center. The clinical characteristics and neonatal outcomes of 153 patients with sIUGR under expectant management were evaluated, and the risk factors leading to adverse outcomes were explored.ResultsFifty‐one patients (33.3%) showed a changed pattern in umbilical artery Doppler at the last examination, occurring in all types of sIUGR. Compared with type Ia, the gestational age of diagnosis was earlier, the estimated fetal body weight difference at diagnosis was greater, and the rate of severe neonatal complications in both fetuses was significantly higher in type Ib (P < 0.05). Univariate and multivariate logistic regression analyses showed that type II (odds ratio [OR] 5.41, 95% confidence interval [CI] 2.34–12.51; P < 0.001) and type III (OR 9.11, 95% CI 3.02–27.50; P < 0.001) were associated with adverse perinatal outcomes in sIUGR.ConclusionType II and III sIUGR are independent risk factors predicting adverse outcomes of sIUGR. Different types of sIUGR could convert to each other. The outcome of type Ib is poorer than that of type Ia.
Factors associated with COVID‐19 vaccination likelihood during pregnancy
Authors: Wainstock Tamar , Sergienko Ruslan , Orenshtein Shani , Sheiner Eyal 
Published: January 2023

AbstractObjectiveTo identify maternal background, medical and gynecological characteristics associated with COVID‐19 vaccination likelihood, in the context where COVID‐19 vaccination rates among pregnant women are significantly lower than the general population.MethodsIn a retrospective cohort study, including all women who delivered between January and September 2021, background and medical history, including current and previous pregnancies diagnoses, were compared between vaccinated and unvaccinated women. Multivariable logistic models were used to identify factors associated with vaccination for the entire population, and for the two distinctive populations included in the study (Bedouin Arabs and Jewish women).ResultsThe study population included 7017 women, of whom 1925 (27.4%) were vaccinated during pregnancy. According to the multivariable analysis, unvaccinated mothers were younger with lower socioeconomic score. They were more likely to be Bedouin Arabs, have a poor obstetrical history or recurrent pregnancy loss, and insufficient prenatal care. Additional risk factors were inconsistent between the two ethnicities included in the study.ConclusionsEthnicity, insufficient prenatal care, and having a poor obstetric history were consistently associated with lower vaccination among pregnant women. These factors should be considered in future plans aimed at increasing vaccination among pregnant women.