bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive comparison of different parts of Paeonia ostii, a food-medicine plant, based on untargeted metabolomics, quantitative analysis, and bioactivity analysis
Authors: Zheng Yaping , Li Pei , Shen Jie , Yang Kailin , Wu Xinyan , Wang Yue , Yuan Yu-he , Xiao Peigen , He Chunnian 
Published: August 2023

IntroductionPaeonia ostii T. Hong &amp; J.X. Zhang (s.s.) (Chinese name, Fengdan) is a widely cultivated food-medicine plant in China, in which root bark, seed kernels, and flowers are utilized for their medicinal and edible values. However, other parts of the plant are not used efficiently, in part due to a poor understanding of their chemical composition and potential biological activity.MethodsUntargeted ultra-performance liquid chromatography–quadrupole time of flight–mass spectrometry (UPLC-Q-TOF-MS) metabolomics was applied to characterize the metabolic profiles of 10 different parts of P. ostii.Results and discussionA total of 160 metabolites were alternatively identified definitely or tentatively, which were significantly different in various plant parts by multivariate statistical analysis. Quantitative analysis showed that underutilized plant parts also contain many active ingredients. Compared with the medicinal part of root bark, the root core part still contains a higher content of paeoniflorin (17.60 ± 0.06 mg/g) and PGG (15.50 ± 2.00 mg/g). Petals, as an edible part, contain high levels of quercitrin, and stamens have higher methyl gallate and PGG. Unexpectedly, the ovary has the highest content of methyl gallate and rather high levels of PGG (38.14 ± 1.27 mg/g), and it also contains surprisingly high concentrations of floralalbiflorin I. Paeoniflorin (38.68 ± 0.76 mg/g) is the most abundant in leaves, and the content is even higher than in the root bark. Branches are also rich in a variety of catechin derivatives and active ingredients such as hydrolyzable tannins. Seed kernels also contain fairly high levels of paeoniflorin and albiflorin. Fruit shells still contain a variety of components, although not at high levels. Seed coats, as by-products removed from peony seeds before oil extraction, have high contents of stilbenes, such as trans-gnetin H and suffruticosol B, showing significant potential for exploitation. Except for the seed kernels, extracts obtained from other parts exhibited good antioxidant activity in DPPH, ABTS, and ferric ion reducing antioxidant power (FRAP) assays (0.09–1.52 mmol TE/g). Five compounds (gallic acid, PGG, trans-resveratrol, kaempferol, and quercitrin) were important ingredients that contributed to their antioxidant activities. Furthermore, P. ostii seed cakes were first reported to possess agonistic activity toward CB1/CB2 receptors. This study provides a scientific basis for the further development and utilization of P. ostii plant resources.
Assessment of Health-Related Quality of Life for Patients with Inflammatory Bowel Diseases in Palestine
Authors: Smerat Tasneem , Khdour Maher , Abdoh Qusay , Hallak Hussein 
Published: August 2023

Background: Inflammatory bowel disease (IBD) has a significant impact on quality of life (QoL). Disease activity has been suggested as an important indicator for QoL in patients with IBD. The aim of this study was to examine the association between disease activity and patient QoL.
Methods: A correlation cross-sectional study was conducted from July 2017 to February 2018. We collected a convenience sample from three major hospitals in southern and northern Palestine. A disease-specific inflammatory bowel disease questionnaire (IBDQ) was used to examine QoL and the results were analyzed using SPSS version 20.
Findings: 132 patients were involved in this study. The mean age was 34 years (SD 13) and 77 (58.3%) patients were men. Active disease had been reported in 81 participants (61.4%) in the previous six months. The average IBDQ scores were 150.72 ± 30.08. Emotional and bowel domains were more disrupted than other domains. Active disease was the major significant factor associated with IBD patients’ QoL in all-dimensional scores (p<0.001). Regression analysis revealed that patients in remission (r2 = 0.436, p<0.001), with high educational status (r2 =0.035, p=0.009) and using azathioprine (r2 =0.017, p=0.034) were independently associated with high QoL.
Conclusions: This study showed a low QoL among Palestinian IBD patients compared to other countries, and identified a number of significant associated factors that should be considered when dealing with IBD.
Analisis Penentuan Strategi Bisnis Gula Semut Kelapa Pada Koperasi Semi Rahayu Mandiri
Authors: Astuti Afi Wiji , Hendrawan Aji Kusumastuti , Iswahyuni Anisha Dian 
Published: August 2023

Coconut ant sugar belonging to the Semi Rahyau Mandiri Cooperative is one of the superior products in Prapagan Village. Coconut ant sugar is one of the good quality sugars that is suitable for export. However, the Semi Rahayu Mandiri Cooperative still sells the coconut ant sugar to middlemen at a low price. Even though cooperatives have a great opportunity to develop their business independently. Cooperatives do not yet have a strategy to develop the business. The aim of the research is to formulate a business strategy for coconut ant sugar Koprasi Semi Rahayu Mandiri. The method used is the SWOT analysis method and the business model canvas approach. The results obtained by the position of the Semi Rahayu Mnadiri Cooperative's ant sugar business are in quadrant I (aggressive) with IFAS (1.3525) and EFAS (4.085) values. The actions taken are to improve the quality of coconut ant sugar products, increase the promotion of coconut ant sugar, maintain the label and brand as the hallmark of processed coconut ant sugar from the Semi Rahayu Mandiri Cooperative, and maintain the legality of the coconut ant sugar business of the Semi Rahayu Mandiri Cooperative. Apart from that, strategy visualization is also produced using the business model canvas approach.
Keywords: Business Strategy, Bussniness Model Canvas, Coconut ant sugar, SWOT
Pengaruh Kualitas Produk, Promosi, Dan Persepsi Harga Terhadap Keputusan Pembelian Fore Coffee
Authors: Edvin Fairliantina Nur Indah Ramahdani 
Published: August 2023

This study aims to determine whether or not there is an effect of Product Quality, Promotion, and Price Perception on Purchasing Decisions at Fore Coffee partially and simultaneously. This research is quantitative, the data is taken from distributing questionnaires with a total of 150 respondents. The method used is purposive sampling method with SPSS 25 as data processing. The results of data processing show that from the t test, the product quality variable has a positive and significant effect on purchasing decisions. Meanwhile, the promotion and price perception variables show a positive and significant influence on purchasing decisions. Testing with the F test results the variables of product quality, promotion, and price perception have a simultaneous or joint effect on purchasing decisions. So the researcher draws the conclusion that product quality, promotion, price perception Fore is good enough and meets consumer expectations so that it influences purchasing decisions at Fore Coffee.
Keywords: Product Quality, Promotion, Price Perception, and Purchase Decision
Penelitian ini bertujuan untuk mengetahui ada atau tidaknya pengaruh Kualitas Porduk, Promosi, dan Persepsi Harga terhadap Keputusan Pembelian di Fore Coffee secara parsial dan secara bersama-sama. Penelitian ini bersifat kuantitatif, data diambil dari penyebaran kuesioner dengan total 150 responden. Metode yang digunakan yaitu metode purposive sampling dengan SPSS 25 sebagai pengolahan data. Hasil dari pengolahan data menunjukkan dari pengujian t hitung variabel kualitas produk berpengaruh secara positif dan signifikan terhadap keputusan pembelian. Sedangkan variabel promosi dan persepsi harga menunjukkan adanya pengaruh secara positif dan signifikan terhadap keputusan pembelian. Pengujian dengan uji F hasilnya variabel kualitas produk, promosi, dan persepsi harga berpengaruh secara simultan atau bersama-sama terhadap keputusan pembelian. Jadi peneliti menarik kesimpulan yaitu kualitas produk, promosi, persepsi harga Fore sudah cukup bagus dan memenuhi harapan konsumen sehingga berpengaruh terhadap keputusan pembelian di Fore Coffe.
Kata Kunci: Kualitas Produk, Promosi, Persepsi Harga, dan Keputusan Pembelian
Ruptura traqueal em cão - relato de caso
Authors: Carvalho Caroline Stéphanie Rodrigues , De Faria Junior Domingos 
Published: August 2023

Rupturas traqueias apresentam alto risco e são incomuns em cães, ocorrem normalmente devido a lesões traumáticas como mordeduras, mas podem ser causadas iatrogenicamente. O enfisema subcutâneo ocorre secundário ao extravasamento de ar pelo defeito e pode se tornar generalizado se não corrigido rapidamente, outros sintomas incluem dispneia e cianose. O diagnóstico é realizado atraves dos sinais clínicos, histórico de brigas, traumas ou intubação recentes e exploração cirúrgica seguida da correção do defeito. O tratamento clínico não é recomendado na maioria dos casos. O prognóstico é favorável desde que a ruptura seja corrigida precocemente. O presente estudo relata um animal apresentando enfisema subcutâneo generalizado secundário a ruptura traqueal tratado cirurgicamente
Using Mobile Gaming in Virtual Physical Education
Authors: Valdez Paolo Nino , Mariano Janet , Cordova Ma. Socorro Gigi 
Published: August 2023

Recent research in education during the COVID-19 pandemic has revealed several structural inequalities leading to problematic implementation of teaching and learning programs globally. However, while the use of communication technology has been greatly capitalized to bridge the physical distance between teachers and students, certain subjects such as Physical Education (henceforth PE) poses logistical challenges in terms of implementation since it entails actual development of physical skills on the part of the learner. This reflective piece examined the use of mobile gaming as an alternative to traditional Physical education programs. Specifically, we argue that mobile gaming helps develop peer engagement, critical thinking, and communication skills. On the other hand, challenges such as a need to engage in more physical activities, addiction and access to technology were encountered.
PELAKSANAAN PEMBANGUNAN OLEH PEMERINTAH DESA PENDAWAN KECAMATAN SAMBAS BERDASARKAN UNDANG-UNDANG NOMOR 6 TAHUN 2014 TENTANG DESA
Authors: Firmansyah Yuman , Milasari  
Published: August 2023

Pelaksanaan Pembangunan Desa merupakan salah satu kewajiban pemerintahan desa yang harus dilaksanakan dan merupakan bidang yang memerlukan pendanaan yang cukup besar, hal ini dikarenakan pelaksanaan pembangunan desa difokuskan pada pembangunan infrastruktur yang ada di desa. Pembangunan desa dapat terlaksana karena adanya Dana Desa yang merupakan hasil kebijakan dari disahkannya Undang-Undang Nomor 6 Tahun 2014 Tentang Desa, Namun yang terjadi di desa pendawan, tepatnya tahun 2020, terdapat rencana pembangunan yang masuk kedalam RKPDes tahun 2020, namun tidak dilaksanakan hingga saat ini. Adapun permasalahan dalam penelitian ini adalah pelaksanaan pembangunan Barau Sungai di Desa Pendawan yang di rencanakan sejak dulu hingga sekarang masih belum terlaksana. Tujuan dari penelitian ini agar dapat mengetahui faktor pendukung dan penghambatnya pembangunan di Desa Pendawan Kecamatan Sambas Kabupaten Sambas. Jenis penelitian ini adalah menggunakan jenis penelitian kualitatif dengan metode field research dan menggunakan pendekatan yuridis empiris, teknik pengumpulan data yang digunakan adalah wawancara dan dokumentasi berdasarkan sumber primer yang ada di lapangan dan sumber data sekunder berupa buku-buku atau karya ilmiah penelitian terkait penelitian ini. Hasil penelitian ini menunjukkan bahwa banyaknya faktor penghambat dalam pembangunan di desa, dikarenakan dana yang terbatas membuat pembangunan menjadi terhambat. Pelaksanaan pembangunan akan terus dilaksanakan sesuai peraturan desa dan Undang-undang Nomor 6 Tahun 2021 Tentang Desa.
DISGRAFIA E DISORTOGRAFIA: CEONCEITUAÇÃO E DIFERENÇAS
Authors: Aparecida Cerqueira Rodrigues Michele 
Published: August 2023

Vive-se diante de uma quantidade alta de informações diárias recebidas, e durante uma busca na internet é possível obter inúmeras eferências acerca das dificuldades de aprendizagem. Contudo, faz-se importante analisar os dados de maneira crítica a fim de erificar a veracidade do conteúdo. Sob essa perspectiva o objetivo deste artigo versa na necessidade de esclarecer as diferenças ntre a disortografia e a disgrafia. Por meio de pesquisa exploratória de cunho bibliográfico foram encontrados 14 artigos. A partir do étodo PRISMA, encontrou-se 28% de relevância para fins de aprofundamento. Percebeu-se a relevância em se expor as iferenças ntre a disgrafia e a disortografia com o intuito de prover aos docentes e profissionais da educação material para estudo. Por fim, constatou-se a necessidade do aumento de publicações relacionados ao tema para disseminação da ciência e suporte a rea cadêmica.
Hemşirelik Öğrencilerinde Algılanan Stres, Başetme ve Merhamet Yorgunluğu
Authors: EVLİ Mahmut 
Published: August 2023

Amaç: Bu araştırmada hemşirelik öğrencilerinde algılanan stres, stresle başetme ve merhamet yorgunluğunun ilişki ve etkileşim düzeylerinin ortaya çıkarılması amaçlanmıştır.
Yöntem: Tanımlayıcı ve ilişki arayıcı tipteki araştırmaya 206 hemşirelik öğrencisi örnekleme dahil edilmiştir. Veriler online olarak hazırlanan “Kişisel Bilgi Formu”, “Merhamet Yorgunluğu-Kısa Ölçek”, “Stresle Başa Çıkma Ölçeği” ve “Algılanan Stres Ölçeği” ile toplanmıştır. Verilerin analizinde tanımlayıcı istatistiklerin (frekans, yüzde, ortalama, standart sapma) yanı sıra Spearman Korelasyon testi ve yapısal eşitlik modellemesi uygulanmıştır.
Bulgular: Katılımcıların %88.3’ü kadın ve yaş ortalaması 22.14±5.69 yıldır. Merhamet yorgunluğunun stresle başa çıkma ile negatif yönde, algılanan stresle pozitif yönde ilişkisi olduğu saptanmıştır. Kurulan yapısal eşitlik modeli veriler tarafından desteklenmektedir. Hemşirelik öğrencilerinin merhamet yorgunluk düzeyleri algılanan stres ve stresle başetme düzeylerinden etkilenmektedir (p0.05).
Sonuç: Sonuç olarak, bu bulgular doğrultusunda öğrencilerin merhamet yorgunluğu düzeyleri ve aracı etkiye sahip değişkenler üzerine araştırmaların yapılması önerilmektedir. Ayrıca stresle başetme becerilerinin artırılmasına yönelik eğitimlerin verilmesi hem stres hem de merhamet yorgunluk düzeyine olumlu etkilerinin olacağı düşünülmektedir.
Hemşirelik Öğrencilerinin Kadına Yönelik Şiddet Hakkında Tutumlarının İncelenmesi
Authors: YANIKKEREM Emre , ESMERAY Nicole 
Published: August 2023

Amaç: Bu çalışmanın amacı hemşirelik öğrencilerinin kadına yönelik şiddet hakkında tutumlarının incelenmesidir.
Yöntem: Kesitsel olarak yürütülen bu araştırmanın evrenini 2018-2019 eğitim öğretim yılında Manisa Celal Bayar Üniversitesi Sağlık Bilimleri Fakültesi hemşirelik bölümünde kayıtlı olan öğrenciler oluşturmuştur (N=845). Araştırmanın minimum örneklemi Epi İnfo programı evreni bilinen formül kullanılarak %95 güven aralığı ve %5 sapma ile 544 kişi olarak belirlenmiştir. Bu çalışma 601 öğrenci tamamlanmıştır. Veriler 01.01.2019–31.12.2019 tarihleri arasında yüz yüze görüşme tekniği ile toplanmıştır. Bu araştırmada sosyodemografik soru formu ve İSKEBE Kadına Yönelik Şiddet Tutum Ölçeği kullanılmıştır.
Bulgular: Bu çalışmada öğrencilerin yaş ortalaması 20.7±1.8 olup, %70.2’si 21 yaş ve altındadır. Araştırmada İSKEBE Kadına Yönelik Şiddet Tutum Ölçeği toplam puan ortalaması 133.4±15.1 (median: 138.0, min:69.0, maks:150), alt boyut puan ortalaması bedene yönelik tutumlar için 76.5±6.2 (median: 79.0, min:45.0, maks:80) ve kimliğe yönelik tutumlar için 53.1±9.3 (median: 55.0, min:16.0, maks:75) olarak bulunmuştur. Hemşirelik öğrencilerinin %8.8’i fiziksel şiddete maruz kaldığını ve %43.8’i kadına yönelik şiddete tanık olduğunu belirtmiştir. Öğrencilerin %31.3’ü kadına yönelik şiddete ilişkin eğitim aldıklarını, %90.2’si derslerinde kadına yönelik şiddete yer verilmesini istemektedir.
Sonuç: Bu çalışmada 21 yaşın altında olan, il merkezinde doğan, parçalanmış aile yapısına sahip olan, geliri giderine eşit ve ailesi ile evde yaşayan öğrencilerin ölçek toplam puan ortalaması diğer gruplara göre istatistiksel anlamlı olarak yüksek bulunmuştur.
Hemşirelik Öğrencilerinin Ventrogluteal Bölgeye İntramüsküler Enjeksiyon Uygulamasına İlişkin Teorik Bilgilerinin Geliştirilmesinde Simülasyon Yönteminin Etkisi: Bir Ön Test-Son Test Çalışma
Authors: SU Serpil , FIRAT KILIÇ Hülya 
Published: August 2023

Amaç: Bu çalışma, hemşirelik öğrencilerinin ventrogluteal bölgeye intramüsküler enjeksiyon uygulamasına ilişkin teorik bilgilerinin geliştirilmesinde simülasyon yönteminin etkisini değerlendirmek amacı ile gerçekleştirildi.
Yöntem: Bir devlet üniversitesinin hemşirelik bölümünde ön test-son test tek gruplu yarı deneysel olarak yapılan araştırma gönüllü 30 öğrenci ile tamamlandı. Kurum izni ve etik kurul onayı alınan araştırmanın verileri anket formu kullanılarak 29 Mayıs-12 Haziran 2017 tarihleri arasında toplandı. Veriler sayı, yüzde, standart sapma, Mann-Whitney U Testi, Kruskal Wallis Testi, Spearman Korelasyon Testi ve Wilcoxon Testi kullanılarak analiz edildi.
Bulgular: Öğrenciler simülasyon öncesi en fazla doğru yanıtı “Dokuya girdikten sonra ilacı vermeden önce piston geriye çekilerek kan kontrolü yapılır” (%96.7) önermesine verirken, simülasyon sonrasında ise “Enjeksiyon yeri antiseptik bir tamponla enjeksiyon yerinden dışa doğru 5 cm çapında dairevi şekilde silinir” (%100), “Antiseptik solüsyon kuruduktan sonra enjeksiyon uygulanır” (%100), “İlaç birkaç saniyede hızlı bir şekilde enjekte edilir” (%100), “Enjeksiyon yaptıktan sonra enjeksiyon bölgesine masaj yapılır” (%100) önermelerine verdi. Öğrencilerin simülasyon öncesi bilgi puan ortalamaları (14.80±2.55) ile simülasyon sonrası bilgi puan ortalamaları (17.13±1.88) arasında ileri düzeyde anlamlı ilişki bulundu.
Sonuç: Bu çalışmada, hemşirelik öğrencilerinin ventrogluteal bölgeye intramüsküler enjeksiyon uygulama bilgilerinin geliştirilmesinde simülasyonun etkili bir öğretim yöntemi olduğu saptandı.
ERECTILE DYSFUNCTION AND OBESITY IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA AND ARTERIAL HYPERTENSION
Authors: Alekseeva T. A. , Gamidov S. I. , Elfimova E. M. , Starostin I. V. , Litvin A. Y. , Chazova I. Y. 
Published: August 2023

Objective: to study the relationship between erectile dysfunction and obesity parameters and the severity of obstructive sleep apnea in patients with arterial hypertension.Material and methods: 71 patients with different severity of erectile dysfunction, overweight and obesity of grade 1, mild and severe obstructive sleep apnea and arterial hypertension were included in the study. The data of cardiorespiratory monitoring, anthropometric parameters of obesity were analyzed and the severity of erectile dysfunction was assessed by intracavernous pharmacodopplerography, the results were compared with the subjective opinion of patients on the degree of severity of erectile dysfunction according to the IIEF-5 questionnaire. All patients underwent psychosomatic status analysis according to the questionnaire scales: assessment of daytime drowsiness on the Epworth scale, severity of personal and situational anxiety on the Spielberger scale and depression level on the Beck scale.Results: comparative analysis revealed statistically significant links between anthropometric data of obesity with OSA parameters (apnea/hypopnea index, desaturation index) (p<0.05), as well as the severity of erectile dysfunction (in terms of erection and dopplerography with evaluation of the of penile blood flow) (p<0.05). A statistically significant negative relationship between the quality of penile blood flow and the degree of arterial hypertension was revealed too (p=0.02). In a comparative analysis of the subjective state of erectile function and objective examination, no statistically significant association was revealed (p=0.07). As a result of the multifactorial linear regression, we have shown that with an increase of the waist circumference to the hip circumference ratio and a higher apnea/hypopnea index, the condition of penile arterial blood flow worsens, namely, a decrease in the peak systolic blood flow velocity (β=-0.39, p=0.05; β=-0.44, p=0.03, respectively). When assessing the psychosomatic state of patients, a significant correlation has been found between the severity of depression in the Beck scale and the level of personal and situational anxiety according to the Spielberger scale (p<0.05). The relationship between depression level on the Beck scale and the degree of situational anxiety with the severity of erectile dysfunction on the Juname scale has been also shown (p<0.05). Conclusion: the combination of overweight or obesity with obstructive sleep apnea and arterial hypertension gives ground to suspect the presence of different severity of erectile dysfunction. The severity of ED is directly proportional to the level of anxiety and depression according to the questionnaire scales.
GENDER FEATURES OF EARLY STENOTIC LESIONS OF CORONARY ARTERIES IN HIGH-RISK PATIENTS WITH THE PRESENCE OF MULTIFOCAL ATHEROSCLEROSIS
Authors: Khasanov A. Kh. , Davletshin R. A. , Karamova I. M. , Kolchina E. M. , Chudnovets L. G. , Amirova A. M. 
Published: August 2023

The aim of the study was to identify individuals with increased frequency of early symptoms of stenosing atherosclerosis of the coronary arteries with consideration of the peculiarities of comorbid abnormalities in CHD patients high risk with the presence of MFA.Materials and methods. Patients of middle age were divided into 3 clusters by the method of hierarchical analysis of categorical variables according to the clinical manifestation of atherosclerotic lesions of the heart, brain and arteries of the lower extremities. Patients evaluated the clinical status, ECG, CAG, echodopplerography carotid and lower limb arteries. According to the indications, magnetic resonance imaging of the chest and abdomen, spirography, fibro-gastroduodenoscopy, ultrasound of the abdominal cavity and kidneys, if necessary, ultrasound of the pelvis were performed.Results. It was found that one of the manifestations of coronary artery disease was ACS with hemodynamically significant PKA stenosis (76-90%), which developed in 50% of women with primary lesion of the 3rd segment of PKA, belonging to the 3rd cluster of the examined. The structure of hemodynamically significant changes in LCA branches was dominated by men of the 1st cluster with lesions of the 6th segment of PHA, DV, 15 segment of OA, while unstable angina was established in 54,2% of them, in the anamnesis - in 51,1%. Frequency of the level of the border of stenosis (50-75%) branches LKA showed a male predominance of the 1-St cluster with a lesion of the 6th segment PMRA involving DV and 15 of the OA segment, coupled with clinic stable angina.Conclusion. The nature of coronary vessels lesions in men and women of the middle age category revealed persons with an increased frequency of signs of stenotic remodeling, taking into account the clinical symptoms and features of vascular comorbid burden in patients with high-risk IHD with the presence of MFA.