bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots
Authors: Albiñana Clara , Zhu Zhihong , Borbye-Lorenzen Nis , Boelt Sanne Grundvad , Cohen Arieh S. , Skogstrand Kristin , Wray Naomi R. , Revez Joana A. , Privé Florian , Petersen Liselotte V. , Bulik Cynthia M. , Plana-Ripoll Oleguer , Musliner Katherine L. , Agerbo Esben , Børglum Anders D. , Hougaard David M. , Nordentoft Merete , Werge Thomas , Mortensen Preben Bo , Vilhjálmsson Bjarni J. , McGrath John J. 
Published: February 2023

AbstractThe vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.
Photocatalytic cyclohexane oxidation and epoxidation using hedgehog particles
Authors: Montjoy Douglas G. , Wilson Elizabeth A. K. , Hou Harrison , Graves Joel D. , Kotov Nicholas A. 
Published: February 2023

AbstractInorganic particles are effective photocatalysts for the liquid-state production of organic precursors and monomers at ambient conditions. However, poor colloidal stability of inorganic micro- and nanoparticles in low-polarity solvents limits their utilization as heterogeneous catalysts and coating them with surfactants drastically reduces their catalytic activity. Here we show that effective photo-oxidation of liquid cyclohexane (CH) is possible using spiky particles from metal oxides with hierarchical structure combining micro- and nanoscale structural features engineered for enhanced dispersibility in CH. Nanoscale ZnO spikes are assembled radially on α-Fe2O3 microcube cores to produce complex ‘hedgehog’ particles (HPs). The ‘halo’ of stiff spikes reduces van der Waals attraction, preventing aggregation of the catalytic particles. Photocatalysis in Pickering emulsions formed by HPs with hydrogen peroxide provides a viable pathway to energy-efficient alkane oxidation in the liquid state. Additionally, HPs enable a direct chemical pathway from alkanes to epoxides at ambient conditions, specifically to cyclohexene oxide, indicating that the structure of HPs has a direct effect on the recombination of ion-radicals during the hydrocarbon oxidation. These findings demonstrate the potential of inorganic photocatalysts with complex architecture for ‘green’ catalysis.
Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice
Authors: Shmarakov Igor O. , Gusarova Galina A. , Islam Mohammad N. , Marhuenda-Muñoz María , Bhattacharya Jahar , Blaner William S. 
Published: February 2023

AbstractRetinoids are potent transcriptional regulators that act in regulating cell proliferation, differentiation, and other cellular processes. We carried out studies in male mice to establish the importance of local cellular retinoid stores within the lung alveolus for maintaining its health in the face of an acute inflammatory challenge induced by intranasal instillation of lipopolysaccharide. We also undertook single cell RNA sequencing and bioinformatic analyses to identify roles for different alveolar cell populations involved in mediating these retinoid-dependent responses. Here we show that local retinoid stores and uncompromised metabolism and signaling within the lung are required to lessen the severity of an acute inflammatory challenge. Unexpectedly, our data also establish that alveolar cells other than lipofibroblasts, specifically microvascular endothelial and alveolar epithelial cells, are able to take up lipoprotein-transported retinoid and to accumulate cellular retinoid stores that are directly used to respond to an acute inflammatory challenge.
Synergistic effect of crevice corrosion and galvanic coupling on 304SS fasteners degradation in chloride environments
Authors: Daniel Enobong Felix , Wang Changgang , Li Chao , Dong Junhua , Zhang Dongjiu , Zhong Wenan , Zhong Sheng , Udoh Inime Ime , Okafor Peter Chukwuemeka 
Published: February 2023

AbstractThe synergistic effect of crevice corrosion and galvanic coupling on the degradation of 304 stainless steel fasteners exposed to a chloride environment was investigated using electrochemical and surface analysis techniques. Results obtained revealed that the crevice region of the fastener showed lower corrosion resistance due to decreased surface passivation induced by the crevice geometry and low oxygen conditions, while the exposed region with a higher oxygen supply exhibited improved corrosion resistance. Coupling of the exposed and crevice regions of the fastener demonstrated accelerated corrosion attributable to galvanic effect. The driving force for the galvanic effect on the fastener was linked to three (3) key factors: (I) the potential difference established between the different regions on the fastener surface due to uneven oxygen distribution, (II) the difference in the solution environment, and (III) the difference in surface properties (active-passive surface). Morphological studies showed localised corrosion occurring mainly in the crevice.
Suppressed basal melting in the eastern Thwaites Glacier grounding zone
Authors: Davis Peter E. D. , Nicholls Keith W. , Holland David M. , Schmidt Britney E. , Washam Peter , Riverman Kiya L. , Arthern Robert J. , Vaňková Irena , Eayrs Clare , Smith James A. , Anker Paul G. D. , Mullen Andrew D. , Dichek Daniel , Lawrence Justin D. , Meister Matthew M. , Clyne Elisabeth , Basinski-Ferris Aurora , Rignot Eric , Queste Bastien Y. , Boehme Lars , Heywood Karen J. , Anandakrishnan Sridhar , Makinson Keith 
Published: February 2023

AbstractThwaites Glacier is one of the fastest-changing ice–ocean systems in Antarctica1–3. Much of the ice sheet within the catchment of Thwaites Glacier is grounded below sea level on bedrock that deepens inland4, making it susceptible to rapid and irreversible ice loss that could raise the global sea level by more than half a metre2,3,5. The rate and extent of ice loss, and whether it proceeds irreversibly, are set by the ocean conditions and basal melting within the grounding-zone region where Thwaites Glacier first goes afloat3,6, both of which are largely unknown. Here we show—using observations from a hot-water-drilled access hole—that the grounding zone of Thwaites Eastern Ice Shelf (TEIS) is characterized by a warm and highly stable water column with temperatures substantially higher than the in situ freezing point. Despite these warm conditions, low current speeds and strong density stratification in the ice–ocean boundary layer actively restrict the vertical mixing of heat towards the ice base7,8, resulting in strongly suppressed basal melting. Our results demonstrate that the canonical model of ice-shelf basal melting used to generate sea-level projections cannot reproduce observed melt rates beneath this critically important glacier, and that rapid and possibly unstable grounding-line retreat may be associated with relatively modest basal melt rates.
Fetal growth restriction followed by early catch-up growth impairs pancreatic islet morphology in male rats
Authors: Jabary Mahboba , Onoda Atsuto , Kitase Yuma , Ueda Kazuto , Mimatsu Haruka , Go Shoji , Miura Ryosuke , Tsuji Masahiro , Takahashi Yoshiyuki , Hayakawa Masahiro , Sato Yoshiaki 
Published: February 2023

AbstractFetal growth restriction (FGR), followed by postnatal early catch-up growth, is associated with an increased risk of metabolic dysfunction, including type 2 diabetes in humans. This study aims to determine the effects of FGR and early catch-up growth after birth on the pathogenesis of type 2 diabetes, with particular attention to glucose tolerance, pancreatic islet morphology, and fibrosis, and to elucidate its mechanism using proteomics analysis. The FGR rat model was made by inducing mild intrauterine hypoperfusion using ameroid constrictors (ACs). On day 17 of pregnancy, ACs were affixed to the uterine and ovarian arteries bilaterally, causing a 20.9% reduction in birth weight compared to sham pups. On postnatal day 4 (P4), the pups were assigned to either the good nutrition (GN) groups with 5 pups per dam to ensure postnatal catch-up growth or poor nutrition groups with 15 pups per dam to maintain lower body weight. After weaning, all pups were fed regular chow food ad libitum (P21). Rats in both FGR groups developed glucose intolerance; however, male rats in the FGR good nutrition (FGR-GN) group also developed hypertriglyceridemia and dysmorphic pancreatic islets with fibrosis. A comprehensive and functional analysis of proteins expressed in the pancreas showed that FGR, followed by early catch-up growth, severely aggravated cell adhesion-related protein expression in male offspring. Thus, FGR and early catch-up growth caused pancreatic islet morphological abnormalities and fibrosis associated with the disturbance of cell adhesion-related protein expressions. These changes likely induce glucose intolerance and dyslipidemia in male rats.
Perceived social support in solo women seeking treatment with donor gametes and in women in heterosexual couples seeking IVF-treatment with own gametes
Authors: Lindell Pettersson Malin , Sydsjö Gunilla , Lampic Claudia , Skoog Svanberg Agneta , Elenis Evangelia 
Published: February 2023

AbstractSolo motherhood is a family constellation that is becoming increasingly common in high income countries. The demographic characteristics of solo women entering treatment with donated sperm or embryo have been shown to be different from that of cohabiting women. The general importance of perceived social support is frequently amplified when health and quality of life are concerned, and positively affects mental health status, experienced stress, perceived self-efficacy during the transition to parenthood and during parenthood itself. The objective of the present study was to compare demographic characteristics, social network and perceived social support among solo women and cohabiting women awaiting fertility treatment. This objective was explored with a study-specific demographic and background questionnaire as well as through questions on access to practical support and the Multidimensional Scale of Perceived Social Support (MSPSS) assessing different sources of support. This study is a part of a longitudinal prospective multicenter study of solo women who awaited donation treatment in six Swedish public and private fertility clinics and a comparison group of women who were cohabiting/married to male partner and awaited in vitro fertilization (IVF) treatment with the couple’s own gametes. A total of 670 women were invited and 463 accepted participation (69% response rate); 207 solo women (study group) and 256 cohabiting women (comparison group). The results show significant differences in age, education, and employment between the groups. Solo women were on average 3.6 years older, had a higher level of education, a higher-income profession, and were more frequently working full time. Solo women perceived an equally high degree of social support from their families, significantly higher levels of support from friends and significantly lower support from a significant other compared to cohabiting women. Solo women expected their mother to be the most supportive person in future parenthood, while cohabiting women most often stated their cohabiting partner to fill that role. The study adds to the body of knowledge of solo women as a sociodemographic distinct group going at motherhood alone, stating a high degree of currently perceived and expected social support. The previously studied negative impact that lack of a co-parent might have, may be attenuated by the expected and perceived social support from family and friends.
Genetic monitoring on the world’s first MSC eco-labeled common octopus (O. vulgaris) fishery in western Asturias, Spain
Authors: Pirhadi N. , Parrondo M. , Romero-Bascones A. , Thoppil R. , Martínez J. L. , Fernández-Rueda M. P. , Márquez I. , García-Flórez L. , Dopico E. , Pérez T. , Borrell Y. J. 
Published: February 2023

AbstractOctopus vulgaris (Cuvier, 1797) is a cephalopod species with great economic value. In western Asturias (northwest of Spain), O. vulgaris artisanal fisheries are relatively well monitored and conditionally eco-labeled by the Marine Stewardship Council (MSC). Despite this, the Asturian octopus stocks have not been genetically assessed so far. In order to improve the current fishery plan and contrast the octopus eco-label validity in Asturias, 539 individuals from five regions of the O. vulgaris geographic distribution, including temporal samplings in Asturias, were collected and genotyped at thirteen microsatellite loci. All the samples under analysis were in agreement with Hardy–Weinberg expectations. Spatial levels of genetic differentiation were estimated using F-statistics, multidimensional scaling, and Bayesian analyses. Results suggested that the O. vulgaris consists of at least four genetically different stocks coming from two ancestral lineages. In addition, temporal analyses showed stability in terms of genetic variation and high NE (> 50) for several generations in different localities within Asturias, pointing out to indeed sustainable fishery exploitation levels. Even though, the current Asturias fishery plan shows no significant genetic damages to the stocks, the regional-specific management plans need systematic genetic monitoring schemes as part of an efficient and preventive regional fishery regulation strategy.
Relationship between manual dexterity and left–right asymmetry of anatomical and functional properties of corticofugal tracts revealed by T2-weighted brain images
Authors: Oka Noriyuki , Sakoh Masaharu , Hirayama Misato , Niiyama Mayu , Gjedde Albert 
Published: February 2023

AbstractThe corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal intensities of the left and right CFT regions to hand function are unknown. Here, we tested the hypothesis that the different signal intensities between the left and right CFT signify clinically important differences of hand motor function. Eleven right-handed and eleven left-handed healthy volunteers participated in the study. Based on horizontal T2WI estimates, we confirmed the relationship between the signal intensity ratios of the peak values of each CFT in the posterior limbs of the internal capsules (right CFT vs. left CFT). The ratios included the asymmetry indices of the hand motor functions, including grip and pinch strength, as well as the target test (TT) that expressed the speed and accuracy of hitting a target ([right-hand score − left-hand score]/[right-hand score + left-hand score]), using simple linear regression. The signal intensity ratios of each CFT structure maintained significant linear relations with the asymmetry index of the speed (R2 = 0.493, P = 0.0003) and accuracy (R2 = 0.348, P = 0.004) of the TT. We found no significant association between left and right CFT structures for grip or pinch strengths. The findings are consistent with the hypothesis that the different signal intensities of the left and right CFT images captured by T2WI serve as biological markers that reflect the dominance of manual dexterity.
Towards environmental detection, quantification, and molecular characterization of Anopheles stephensi and Aedes aegypti from experimental larval breeding sites
Authors: Kristan Mojca , Acford-Palmer Holly , Campos Monica Oliveira , Collins Emma L. , Phelan Jody , Portwood Natalie M. , Pelloquin Bethanie , Clarke Sian , Lines Jo , Clark Taane G. , Walker Thomas , Campino Susana , Messenger Louisa A. 
Published: February 2023

AbstractThe invasion and establishment of An. stephensi mosquitoes in the Horn of Africa represents a significant regional threat, which may jeopardise malaria control, particularly in urban areas which were formally free from disease transmission. Novel vector surveillance methods are urgently needed, both agnostic to mosquito larval morphology, and simple to implement at the sampling stage. Using new multiplex TaqMan assays, specifically targeting An. stephensi and Ae. aegypti, we validated the use of environmental DNA (eDNA) for simultaneous vector detection in shared artificial breeding sites. Study findings demonstrated that An. stephensi and Ae. aegypti eDNA deposited by as few as one second instar larva in 1L of water was detectable. Characterization of molecular insecticide resistance mechanisms, using novel amplicon-sequencing panels for both vector species, was possible from eDNA shed by as few as 16–32 s instar larvae in 50 ml of water. An. stephensi eDNA, derived from emergent pupae for 24 h, was remarkably stable, and still detectable ~ 2 weeks later. eDNA surveillance has the potential to be implemented in local endemic communities and at points of country entry, to monitor the spread of invasive vector species. Further studies are required to validate the feasibility of this technique under field conditions.
A photonic artificial synapse with a reversible multifaceted photochromic compound
Authors: Sharma Deeksha , Rao Dheemahi , Saha Bivas 
Published: February 2023

Sharma et al. show an all-optical artificial synapse using a reversible, photochromic organic compound, spiropyran, stimulated by optical pulses. This work shows that spiropyran can be an excellent host for artificial photonic synapses.
Europium doped-double sodium bismuth molybdate nanoparticles as contrast agents for luminescence bioimaging and X-ray computed tomography
Authors: Calderón-Olvera Roxana M. , Núñez Nuria O. , González-Mancebo Daniel , Monje-Moreno Jose M. , Muñoz-Rui Manuel J. , Gómez-González Elisabet , Arroyo Encarnación , Torres-Herrero Beatriz , de la Fuente Jesús M. , Ocaña Manuel 
Published: February 2023

We have synthesized Eu-doped NaBi(MoO4)2 nanoparticles functionalized with PAA whose properties make them excellent multimodal contrast agents for X-ray computed tomography and luminescent bioimaging, as illustrated using a C. Elegans animal model.
Electrochemical conversion of CO2into HCOO−in a synergistic manner by a nanocomposite of Zn2SnO4/ZnO
Authors: Zhang Yingzheng , Li Zijian , Jang Haeseong , Wei Xiaoqian , Qin Qing , Liu Xien 
Published: February 2023

A Zn2SnO4/ZnO nanocomposite is developed for effectively catalyzing the reduction of CO2 to formic acid, owning to the potential capacity to regulate electronic structure by interfacial interaction.
DementiaBank: Theoretical Rationale, Protocol, and Illustrative Analyses
Authors: Lanzi Alyssa M. , Saylor Anna K. , Fromm Davida , Liu Houjun , MacWhinney Brian , Cohen Matthew L. 
Published: February 2023

Purpose:
Dementia from Alzheimer's disease (AD) is characterized primarily by a significant decline in memory abilities; however, language abilities are also commonly affected and may precede the decline of other cognitive abilities. To study the progression of language, there is a need for open-access databases that can be used to build algorithms to produce translational models sensitive enough to detect early declines in language abilities. DementiaBank is an open-access repository of transcribed video/audio data from communicative interactions from people with dementia, mild cognitive impairment (MCI), and controls. The aims of this tutorial are to (a) describe the newly established standardized DementiaBank discourse protocol, (b) describe the Delaware corpus data, and (c) provide examples of automated linguistic analyses that can be conducted with the Delaware corpus data and describe additional DementiaBank resources.

Method:
The DementiaBank discourse protocol elicits four types of discourse: picture description, story narrative, procedural, and personal narrative. The Delaware corpus currently includes data from 20 neurotypical adults and 33 adults with MCI from possible AD who completed the DementiaBank discourse protocol and a cognitive–linguistic battery. Language samples were video- and audio-recorded, transcribed, coded, and uploaded to DementiaBank. The protocol materials and transcription programs can be accessed for free via the DementiaBank website.

Results:
Illustrative analyses show the potential of the Delaware corpus data to help understand discourse metrics at the individual and group levels. In addition, they highlight analyses that could be used across TalkBank's other clinical banks (e.g., AphasiaBank). Information is also included on manual and automatic speech recognition transcription methods.

Conclusions:
DementiaBank is a shared online database that can facilitate research efforts to address the gaps in knowledge about language changes associated with MCI and dementia from AD. Identifying early language markers could lead to improved assessment and treatment approaches for adults at risk for dementia.
ParAlg: A Paraphasia Algorithm for Multinomial Classification of Picture Naming Errors
Authors: Casilio Marianne , Fergadiotis Gerasimos , Salem Alexandra C. , Gale Robert C. , McKinney-Bock Katy , Bedrick Steven 
Published: February 2023

Purpose:
A preliminary version of a paraphasia classification algorithm (henceforth called ParAlg) has previously been shown to be a viable method for coding picture naming errors. The purpose of this study is to present an updated version of ParAlg, which uses multinomial classification, and comprehensively evaluate its performance when using two different forms of transcribed input.

Method:

A subset of 11,999 archival responses produced on the Philadelphia Naming Test were classified into six cardinal paraphasia types using ParAlg under two transcription configurations: (a) using phonemic transcriptions for responses exclusively (
phonemic-only
) and (b) using phonemic transcriptions for nonlexical responses and orthographic transcriptions for lexical responses (
orthographic-lexical
). Agreement was quantified by comparing ParAlg-generated paraphasia codes between configurations and relative to human-annotated codes using four metrics (positive predictive value, sensitivity, specificity, and F1 score). An item-level qualitative analysis of misclassifications under the best performing configuration was also completed to identify the source and nature of coding discrepancies.

Results:

Agreement between ParAlg-generated and human-annotated codes was high, although the
orthographic-lexical
configuration outperformed
phonemic-only
(weighted-average F1 scores of .78 and .87, respectively). A qualitative analysis of the
orthographic-lexical
configuration revealed a mix of human- and ParAlg-related misclassifications, the former of which were related primarily to phonological similarity judgments whereas the latter were due to semantic similarity assignment.

Conclusions:
ParAlg is an accurate and efficient alternative to manual scoring of paraphasias, particularly when lexical responses are orthographically transcribed. With further development, it has the potential to be a useful software application for anomia assessment.

Supplemental Material:

https://doi.org/10.23641/asha.22087763