bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID‐19 in Western Australia: ‘The last straw’ and hopes for a ‘new normal’ for parents of children with long‐term conditions
Authors: Smith Stephanie , Tallon Mary , Smith James , Jones Lauren , Mörelius Evalotte 
Published: June 2023

AbstractBackgroundChildren with long‐term conditions are vulnerable due to the treatments required for their conditions. Since the start of the coronavirus disease 2019 (COVID‐19) pandemic, Western Australians experienced restrictions that changed daily life activities but were able to return to some of their previous routines due to the restrictions.AimThe study explored the stress experiences of parents caring for children with long‐term conditions during COVID‐19 in Western Australia.Design and ParticipantsThe study was codesigned with a parent representative caring for children with long‐term conditions to ensure essential questions were targeted. Twelve parents of children with various long‐term conditions were recruited. Ten parents completed the qualitative proforma, and two parents were interviewed in November 2020. Interviews were audio‐recorded and transcribed verbatim. Data were anonymised and analysed using reflexive thematic analysis.FindingsTwo themes were produced: (1) ‘Keep my child safe’ describes the children's vulnerabilities due to their long‐term conditions, the adjustments parents' made to keep their children safe and the various consequences faced. (2) ‘COVID‐19's silver lining’ covers the positives of the COVID‐19 pandemic, including their children having fewer infections, the availability of telehealth appointments, relationship improvements and the parent's hopes for a new normal where behaviours prevent transmission of infectious (e.g., hand sanitising).ConclusionWestern Australia provided a unique context for the COVID‐19 pandemic due to no transmission of the virus severe acute respiratory syndrome coronavirus 2 at the time of the study. The tend and befriend theory aids in explaining the parents' stress experiences, and the application highlights a unique aspect of this theory. Parents tended to their children during COVID‐19, but many could no longer rely on others for connection, support and respite, and became further isolated in attempting to protect their children due to COVID‐19 consequences. The findings highlight that some parents of children with long‐term conditions need specific attention during times of pandemics. Further review is recommended to support parents through the impact of COVID‐19 and similar crises.Patient or Public ContributionThis study was codesigned with an experienced parent representative who was part of the research team and involved throughout the research process to ensure meaningful end‐user engagement and ensure essential questions and priorities were addressed.
THE COUNTED TIME: TECHNICAL TEMPORALITIES AND THEIR CHALLENGES TO HISTORY
Authors: SILVEIRA PEDRO TELLES DA 
Published: June 2023

ABSTRACTOne of the main debates regarding historical representation within digital media concerns narrative, particularly the difficulty in articulating it. Digital technologies are usually presented as opposed to linear, written narratives, which is of consequence to historical writing. Despite the many merits of scholarly approaches that try to circumvent this difficulty, the lack of theoretical understanding of the categories implied in such discussions is noticeable. To counter this, this article addresses the relationship between time, technics, and narrative. I contend that the challenges of crafting narratives in digital media conceal a problem pertaining to the relationship between time and technics. Drawing on Paul Ricoeur's work on narrative, Jimena Canales's studies of the history of science, Wolfgang Ernst's and Yuk Hui's discussions of technical temporality, and Bernard Stiegler's understanding of the relationship between time and technics, I argue that it is the temporality imbued in the workings of technical objects (such as computers) that renders them averse to narrative. In making this argument, I employ the notion of “counted time” (in contrast to Ricoeur's “narrative time”) to denote a temporal mode that, despite its intersections with social, human temporality, is alien to narrative.
A novel scheelite‐type LiCaGd(WO4)3:Eu3+ red phosphors with prominent thermal stability and high quantum efficiency
Authors: Wang Dong , Guan Xufeng , Li Guifang 
Published: June 2023

AbstractA series of LiCaGd(WO4)3: xEu3+ (0 ≤ x ≤ 1.0) red phosphors with tetragonal scheelite structure were synthesized via the conventional solid‐state reaction. Their crystal structure, photoluminescence excitation (PLE), and photoluminescence (PL) spectra, thermal stability and quantum efficiency were investigated. The phosphors exhibit a typical red light upon 395 nm near ultraviolet excitation, and the strongest emission peak at 617 nm is dominated by the 5D0→7F2 transition of Eu3+ ions. The PL intensity of the phosphors gradually increases with the increase of Eu3+ doping concentration, and the concentration quenching phenomenon is hardly observed. The quantum efficiency and the color purity of the phosphor reach maximum values of about 94.2 and 96.6% at x = 1.0, respectively. More importantly, LiCaGd(WO4)3:xEu3+ phosphors have prominent thermal stability. The temperature‐dependent PL intensity of the phosphors at 423 K is only reduced to 89.1% of the PL intensity at 303 K, which is superior to that of commercial red phosphors Y2O3:Eu3+. Finally, LiCaGd(WO4)3:Eu3+ phosphor is packaged with near ultraviolet InGaN chips to fabricate white light emitting diodes, which has a low color temperature (CCT = 4622 K) and a high color rendering index (CRI= 89.6).
Retrospective analysis of patients with severe combined immunodeficiency and alternative diagnostic criteria: A 20‐year single centre experience
Authors: Korkmaz Sevim Busra , Karaselek Mehmet Ali , Aytekin Selma Erol , Tokgoz Huseyin , Reisli Ismail , Guner Sukru , Keles Sevgi 
Published: June 2023

AbstractSevere combined immunodeficiency (SCID) is an inborn errors of immunity (IEI) disorder characterized by impairment in the development and function of lymphocytes and could be fatal if not treated with hematopoietic stem cell transplant in the first 2 years of life. There are various diagnostic criteria for SCID among different primary immunodeficiency societies. We retrospectively evaluated clinical and laboratory findings of 59 patients followed up with the diagnosis of SCID at our clinic over the past 20 years in order to develop an algorithm that would help diagnosis of SCID for the countries where a high ratio of consanguineous marriage is present because these countries have not launched TREC assay in their newborn screening programs. The mean age at diagnosis was 5.80 ± 4.90 months, and the delay was 3.29 ± 3.99 months. The most common complaint and physical examination findings were cough (29.05%), eczematous rash (63%) and organomegaly (61%). ADA (17%), Artemis (14%), RAG1/2 (15%), MHC Class II (12%) and IL‐2R (12%) deficiencies were the most common genetic defects. Lymphopenia (87.5%) was the most frequent abnormal laboratory finding and below 3000/mm3 in 95% of the patients. The CD3+ T cell count was 300/mm3 and below in 83% of the patients. As a result, a combination of low lymphocyte count and CD3 lymphopenia for SCID diagnosis would be more reliable for countries with high rate of consanguineous marriage. Physicians should consider diagnosis of SCID in a patient presenting with severe infections and lymphocyte counts below 3000/mm3 under 2 years of age.
Potential modifications of the PLASMIC scoring system for predicting thrombotic thrombocytopenic purpura: Sometimes, less is more
Authors: Orhan Bedrettin , Özkocaman Vildan , Akdemir Çiğdem , Ersal Tuba , Pınar İbrahim Ethem , Yalçın Cumali , Candar Ömer , Çubukçu Sinem , Koca Tuba Güllü , Ambarcıoğlu Pınar , Ali Rıdvan , Özkalemkaş Fahir 
Published: June 2023

AbstractIntroductionThrombotic thrombocytopenic purpura (TTP) is a life‐threatening occlusive disease of the microcirculation characterized by systemic platelet plugs, organ ischemia, deep thrombocytopenia, and fragmentation of erythrocytes. One of the widely used scoring system to determine the clinical probability of TTP is the PLASMIC scoring system. This study aimed to evaluate the contribution of PLASMIC score modifications to sensitivity and specificity in patients with microangiopathic hemolytic anemia (MAHA) undergoing plasma exchange with a prediagnosis of TTP at our center.Materials and MethodsThe data of patients who were hospitalized with a previous diagnosis of MAHA and TTP and underwent plasma exchange at Bursa Uludag University, Faculty of Medicine, Department of Hematology between January 2000 and January 2022 were retrospectively analyzed.ResultsOverall, 33 patients (including 15 and 18 with and without TTP, respectively) were included in this study. Receiver operating characteristic (ROC) analysis revealed that the area under the curve (AUC) for the original PLASMIC score was 0.985 (95% confidence interval [95% CI]: 0.955–1.000), and AUC for the PLASMIC score without mean corpuscular volume (MCV) was 0.967 (95% CI: 0.910–1.000), which is close to the original AUC. With the removal of MCV from the scoring system, the sensitivity decreased from 100% to 93%, whereas the specificity increased from 33% to 78%.ConclusionsBased on the results of this validation study, removing MCV from the PLASMIC score led to the categorization of eight non‐TTP cases in the low‐risk category, and this could avoid unnecessary plasma exchange. However, in our study increasing the specificity was at the expense of the sensitivity by missing one patient with this new scoring system without MCV. Further multicenter studies with large sample sizes are required owing to the fact that different parameters may be effective in TTP prediction among different populations.
A positive psychology intervention to foster economic integration of Syrian refugees in the Netherlands
Authors: Muller‐Dugic José , Beckers Pascal J. , Braakman Mario H. 
Published: June 2023

AbstractResearch shows that the labour market integration of refugees is often problematic. Little is known about what kind of measures are effective to help them integrate into the labour market. In the Netherlands, a positive psychology intervention “Mosaic” for Syrian refugees was developed to support their economic participation. This study aims to assess the effect of “Mosaic” on the economic participation and work‐related attitudes of Syrian refugees. “Mosaic” was implemented in six municipalities by conducting an RCT with a waiting list control group. The results show that in the short term, the intervention group realizes a significantly larger increase in hours spent on an internship as well as substantially larger gains in confidence to find work in the future. In the long term, the intervention group experiences larger confidence gains related to finding a job that fits their education and experience.
Nursing assistants' perceptions and experiences with the emotional impact of providing palliative care: A qualitative interview study in nursing homes
Authors: Dijxhoorn Anne‐Floor Q. , Heijnen Yanouk , van der Linden Yvette M. , Leget Carlo , Raijmakers Natasja J. H. , Brom Linda 
Published: June 2023

AbstractAimTo gain insight into the perceived emotional impact of providing palliative care among nursing assistants in Dutch nursing homes, their strategies in coping with this impact and associated needs.DesignExploratory qualitative study.MethodsIn 2022, 17 semistructured interviews with nursing assistants working in Dutch nursing homes were conducted. Participants were recruited via personal networks and social media. Interviews were open‐coded by three independent researchers following the thematic analysis approach.ResultsThree themes emerged regarding the elements that contribute to the emotional impact of providing palliative care in nursing homes: impactful situations (e.g. witnessing suffering and sudden deaths), interactions (e.g. close relationship and receiving gratitude) and reflection on provided care (e.g. feeling fulfilment or feeling inadequate in caring). Nursing assistants used different strategies to cope, including emotional processing activities, their attitude towards death and work and gaining experience. Participants experienced a need for more education in palliative care and organized peer group meetings.ConclusionElements that play a role in how the emotional impact of providing palliative care is perceived by nursing assistants can have a positive or negative impact.Implications for the Profession and/or Patient CareNursing assistants should be better supported in coping with the emotional impact of providing palliative care.ImpactIn nursing homes, nursing assistants are most involved in providing daily care to residents and have a signalling role in recognizing the deteriorating conditions of residents. Despite their prominent role, little is known about the emotional impact of providing palliative care among these professionals. This study shows that although nursing assistants already undertake various activities to reduce the emotional impact, employers should be aware of the unmet needs in this area and the responsibility they have in this regard.Reporting MethodThe QOREQ checklist was used for reporting.Patient or Public ContributionNo patient or public contribution.
Migratory geese allow plants to disperse to cooler latitudes across the ocean
Authors: Lovas‐Kiss Ádám , Martín‐Vélez Víctor , Brides Kane , Wilkinson David M. , Griffin Larry R. , Green Andy J. 
Published: June 2023

AbstractAimHow plants can disperse in response to global change is a critical question, yet major knowledge gaps persist about long‐distance dispersal (LDD) mechanisms. We studied the potential a migratory waterfowl has for LDD of flowering plants via gut passage of seeds (endozoochory), comparing spring and autumn migration.LocationUnited Kingdom and Iceland.TaxonPink‐footed Goose (Anser brachyrhynchus, Baillon) and Angiosperma.MethodsWe studied endozoochory by Pink‐footed geese migrating within and between the UK and Iceland by faecal sampling and GPS tracking. We collected 614 faecal samples from 14 areas in the UK and one in Iceland. Using GPS tracks to and from these areas, we estimated how far seeds can be dispersed by Pink‐footed geese, and where to or from.ResultsWe recorded 5507 intact seeds of 35 species (27 terrestrial) from 15 plant families, with lower seed abundance per dropping when birds were migrating northwards in the UK during spring than upon their arrival in autumn. Species richness of plant seeds was highest in Iceland and in autumn. Only four plant species dispersed had an “endozoochory syndrome”. GPS movements showed that seeds retained in guts for up to 24 h can be readily dispersed in both directions between the UK and Iceland, with maximum distances exceeding 2000 km, as well as between UK localities separated by 100 s of km. Movements northwards of ≤400 km were even recorded in autumn. While at stopover sites, daily movements between roost and feeding sites often exceed 20 km.Main ConclusionsPink‐footed geese are LDD vectors for plants previously assumed to lack an LDD mechanism. Spring migration is not the only period when geese move plants to cooler latitudes. The pink‐footed goose can allow terrestrial and aquatic plants to cross the ocean and to keep pace with climate change.
Long non‐coding ribonucleic acid zinc finger E‐box binding homeobox 1 antisense RNA 1 regulates myocardial fibrosis in diabetes through the Hippo–Yes‐associated protein signaling pathway
Authors: Wu Jing , Lyu Rui , Chen Shumin , Wang Xiaoguang 
Published: June 2023

AbstractAims/IntroductionFibrosis is the principle reason for heart failure in diabetes. Regarding the involvement of long non‐coding ribonucleic acid zinc finger E‐box binding homeobox 1 antisense 1 (ZEB1‐AS1) in diabetic myocardial fibrosis, we explored its specific mechanism.Materials and MethodsHuman cardiac fibroblasts (HCF) were treated with high glucose (HG) and manipulated with plasmid cloning deoxyribonucleic acid 3.1‐ZEB1‐AS1/microribonucleic acid (miR)‐181c‐5p mimic/short hairpin RNA specific to sirtuin 1 (sh‐SIRT1). ZEB1‐AS1, miR‐181c‐5p expression patterns, cell viability, collagen I and III, α‐smooth muscle actin (α‐SMA), fibronectin levels and cell migration were assessed by reverse transcription quantitative polymerase chain reaction, cell counting kit‐8, western blot and scratch tests. Nuclear/cytosol fractionation assay verified ZEB1‐AS1 subcellular localization. The binding sites between ZEB1‐AS1 and miR‐181c‐5p, and between miR‐181c‐5p and SIRT1 were predicted and verified by Starbase and dual‐luciferase assays. The binding of SIRT1 to Yes‐associated protein (YAP) and YAP acetylation levels were detected by co‐immunoprecipitation. Diabetic mouse models were established. SIRT1, collagen I, collagen III, α‐SMA and fibronectin levels, mouse myocardium morphology and collagen deposition were determined by western blot, and hematoxylin–eosin and Masson trichrome staining.ResultsZinc finger E‐box binding homeobox 1 antisense 1 was repressed in HG‐induced HCFs. ZEB1‐AS1 overexpression inhibited HG‐induced HCF excessive proliferation, migration and fibrosis, and diminished collagen I, collagen III, α‐SMA and fibronectin protein levels in cells. miR‐181c‐5p had targeted binding sites with ZEB1‐AS1 and SIRT1. SIRT1 silencing/miR‐181c‐5p overexpression abrogated ZEB1‐AS1‐inhibited HG‐induced HCF proliferation, migration and fibrosis. ZEB1‐AS1 suppressed HG‐induced HCF fibrosis through SIRT1‐mediated YAP deacetylation. ZEB1‐AS1 and SIRT1 were repressed in diabetic mice, and miR‐181c‐5p was promoted. ZEB1‐AS1 overexpression improved myocardial fibrosis in diabetic mice, and reduced collagen I, collagen III, α‐SMA and fibronectin protein levels in myocardial tissues.ConclusionLong non‐coding ribonucleic acid ZEB1‐AS1 alleviated myocardial fibrosis through the miR‐181c‐5p–SIRT1–YAP axis in diabetic mice.
Finding a meaning for pain: Definitions, sense‐making, and philosophical health
Authors: Djordjevic Charles M. 
Published: June 2023

AbstractPain has proven to be a refractory problem in US healthcare. This paper argues that starting to address this requires viewing pain‐assessment as a form of sense‐making that occurs between patients and providers. Section I argues that two standard definitions of ‘pain’ that are thought to subtend pain assessment are not viable. Section II proffers a very different way to think about the meaning of ‘pain’. Section III develops this novel account by pairing Rorty's account of hermeneutics with recent developments in the pain‐assessment literature. Finally, section four moves beyond Rorty by linking sense‐making to philosophical health. Should this prove persuasive, I will have shown an area in biomedicine where philosophy is not an ‘optional add on’, but a vitally important part of what should be clinical practice.
Active chitosan/gelatin‐based films and coatings containing eugenol and oregano essential oil for fresh cheese preservation
Authors: Reyes Méndez Laura María , Méndez Morales Paula Andrea , López‐Córdoba Alex , Ortega‐Toro Rodrigo , Gutiérrez Tomy J. 
Published: June 2023

AbstractThe use of active substance‐containing biodegradable and edible coatings has become a potentially viable alternative for food preservation, especially to retard oxidative processes and the growth of pathogenic and spoilage microorganisms on the surface of the foodstuffs. In this context, the objective of this research was to develop and characterize gelatin (GL)/chitosan (CH)‐based active, biodegradable, and edible films and coatings containing eugenol (EU) and oregano (Origanum vulgare) essential oil (OEO) in different OEO:EU ratios, and obtained via casting for application in fresh cheese. More soluble, wetter, yellower, and opaque films than the control film system were obtained as a consequence of a higher OEO:EU ratio. Although, the water vapor barrier properties in OEO‐containing films were markedly enhanced with respect to control film system. All the films displayed a slight phase separation, but this was more noticeable when increasing the OEO:EU ratio. This could explain the higher moisture content and water solubility values as the OEO:EU ratio increased. The films containing EU and OEO showed antimicrobial activity against Staphylococcus aureus and Escherichia coli. The best film systems were selected and tested as coatings for the preservation of fresh cheese. In particular, the coating F4 (0.5% wt/wt of OEO + 0.5% wt/wt of EU) displayed the best conservation capacity of fresh cheese during 14 days of storage at 4°C. This predominantly through the reduction of the colony‐forming units of S. aureus, total coliforms, and mesophilic aerobic.Practical applicationsThe addition of EU and OEO in CH/GL‐based coatings presented a synergistic effect in terms of their antimicrobial activity. These food packaging materials would be an alternative for the preservation of foods susceptible to contamination by pathogenic and/or spoilage microorganisms during storage. Besides, the addition of OEO improved particularly the barrier properties of active, biodegradable, and edible films, which allows their use as a protection mechanism for high‐moisture and medium‐moisture foods, such as fresh cheese. Overall, assessed coatings could increase the shelf life of fresh cheese in terms of food safety, but not its quality in terms of maintaining its freshness.
EBSD patterns simulating multilayer twins based on dynamical theory of electron diffraction
Authors: Li Xinglin , Li Xiangcheng , Wu Tao , Lv Chenglong , Cai Canying 
Published: June 2023

AbstractElectron backscatter diffraction (EBSD) can be employed to determine crystal structures but has not been used alone to identify defects at the atom scale due to the lack of understanding of the EBSD patterns generated by various structure defects. In the present work, the EBSD patterns of FCC‐Fe with 9‐layer, 6‐layer and 3‐layer twin structures are simulated, respectively, using the revised real space (RRS) method and compared with the counterpart of perfect crystals. Our results show that when the electron beam is incident along a direction parallel to the twin plane, the pattern appears symmetrical with respect to the corresponding Kikuchi band of the twin plane, and the diffraction details within the Kikuchi band also exhibit symmetry with respect to the middle line of the Kikuchi band. Moreover, the overall clarity of the patterns decreases, and the pattern becomes more blurred with increasing the distance from the Kikuchi band corresponding to the twin plane. By contrast, the incident electron beam along the direction perpendicular to the twin plane results in diffraction superposition of the matrix region and the shear region, which shows twofold rotational symmetry with respect to the Kikuchi pole corresponding to the normal to the twin plane. In addition, some extra Kikuchi bands appear in the EBSD patterns due to the long‐period structures of the multilayer twins. As the number of multilayer twins decreases, the number of extra Kikuchi bands decreases and the area of the blurring pattern increases. The correlation between twin structures and EBSD patterns provides theoretical insights for identifying twin structures by the EBSD technique.