bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children's Human Rights to ‘Participation’ and ‘Protection’: Rethinking the relationship using Barnahus as a case example
Authors: Mitchell Mary , Lundy Laura , Hill Louise 
Published: March 2023

AbstractThe relationship between children's human rights to protection and to what is commonly referred to as ‘participation’ has received significant attention, with many scholars critiquing the purported tension between the two approaches and demonstrating how child participation should be a core feature of child protection. Less attention has been paid to the converse and, we argue, essential precursor of participatory protection practice – the significance of the child's right to be protected from harm as a means to ensuring successful child participation. Drawing on the example of the multidisciplinary Barnahus model, this article explores the multifaceted relationship between participation and protection, suggesting that there needs to be greater acknowledgement of the role of collective child participation in delivering the conditions where individual children who have witnessed or experienced violence feel and are safe to express themselves.
Isolation and Characterization of trans‐p‐Hydroxycinnamoyl Meroterpenoids from Ganoderma sinensis
Authors: Yin Yan‐Jiao , Zhou Hong , Zhang Jiao‐Jiao , Cai Dan , Yuan Yuan‐Nan , Yang Zhong‐Hui , Cheng Yong‐Xian 
Published: March 2023

AbstractZizhines V, W, Y, Z, (±)‐zizhines X, and Z1−Z3, and (±)‐ganosinensol L, thirteen new compounds including four pairs of enantiomers and a known compound (−)‐ganosinensol L, were isolated from the fruiting bodies of Ganoderma sinensis. Their structures were identified by spectroscopic, computational methods, and CD (circular dichroism spectroscopy) comparisons. Zizhines V−Z and Z1−Z3 are meroterpenoids consisting of the phenolic and the terpenoidal parts. All the compounds except zizhine Z3 bear a common trans‐p‐hydroxycinnamoyl group. Biological evaluation shows that (−)‐zizhine Z1 inhibits cell migration in the MDA‐MB‐231 cell lines. The present study discloses the chemical profiling of G. sinensis and paves the way for its development as functional products to benefit chronic disorders.
Chemical Composition and Bioactivities of Quercus canariensis Flour Acorns Extracts Growing in Tunisia
Authors: Fkiri Sondes , Essghaier Badiaa , Stiti Boutheina , Achour Hammadi , Ben Slimane Lasâad , Ben Salem Ridha , Nasr Zouhair , Ksouri Riadh , Rigane Ghayth , Khaldi Abdelhamid 
Published: March 2023

AbstractThe current study was conducted to investigate the chemical composition of Quercus canariensis flour acorns extracts as well as its biological activities in regards to the growing area using spectrophotometric and chromatographic techniques. The phenolic profile was composed of 19 compounds identified through HPLC‐DAD analysis. Coumarin was the most abundant compound quantified in BniMtir, Nefza and ElGhorra and gallic (12.58–20.52 %), syringic (4.70–7.64 %) and trans‐ferulic (2.28–2.94 %) acids were the abundant phenolic acids while kaempferol was the major flavonoid compounds quantified only in Quercus canariensis growing in BniMtir. On the other hand, Ain Snoussi acorn extract was characterized by its high content in luteolin‐7‐O‐glucoside (58.46 %). The in‐vitro antioxidant activities of the studied extracts were investigated and the results showed that Nefza ethanolic extract's has the highest activities. A bactericidal effect against Staphylococcus aureus was observed only by Elghorra population. On the other hand, Ain Snoussi acorn extract was efficient to inhibit growth of pathogenic bacteria, mentioned the highest activity against Escherichia coli. These results is the first study highlighted that zeen oak acorns are an excellent source of natural antioxidants and antibacterial compounds related to their lysozyme activity which could be exploited in the pharmaceutical and food sectors.
Extending the Record of Terpenes from Soft Coral Sarcophyton mililatensis
Authors: Yang Min , Ge Zeng‐Yue , Chen Zi‐Hui , Yao Li‐Gong , Liang Lin‐Fu , Guo Yue‐Wei 
Published: March 2023

AbstractIn the present study, a new polyoxygenated cembranoid named sarcomililatol H (1) as well as six known terpenes 2–7 with different skeletons were isolated from South China Sea soft coral Sarcophyton mililatensis. Based on the comprehensive analyses of 1D and 2D NMR spectroscopic data, the structure of the new compound 1 was established. This new cembranoid was characterized by the presence of the rarely encountered tetrahydropyran ring with the ether linkage across C‐2 and C‐12. By applying the time‐dependent density functional theory electronic circular dichroism (TDDFT ECD) approach, the absolute configuration of sarcomililatol H (1) was determined. All of the isolates were subjected to the anti‐inflammatory and anti‐tumor bioassays. However, none of them was active in these evaluations. Additionally, the preliminary virtual screening of inhibitory against SARS‐CoV‐2 by molecular docking showed that diterpene 1 could be regarded as a SARS‐CoV‐2 main protease (Mpro) inhibitor (binding energy: −7.63 kcal/mol). The discovery of these terpenes has expanded the chemical diversity and complexity of terpenes from the species S. mililatensis.
Evaluation of the protective role of resveratrol against sepsis caused by LPS via TLR4/NF‐κB/TNF‐α signaling pathways: Experimental study
Authors: Okan Aslı , Doğanyiğit Züleyha , Yilmaz Seher , Uçar Sümeyye , Arikan Söylemez Evrim Suna , Attar Rukset 
Published: March 2023

AbstractThe development and progression of sepsis are multifactorial and influence the immunological, endocrine, and cardiovascular systems of the body. Our knowledge of the key mechanisms involved in the pathogenesis of sepsis has expanded exponentially, yet this still needs to be translated into effective targeted therapeutic regimes. In the present study, we aimed to determine whether resveratrol has positive effects in the experimental sepsis rat model. Twenty‐eight male Spraque–Dawley rats were randomly divided into four groups (n = 7) as follows: control, lipopolysaccharide (LPS) (30 mg/kg dose), resveratrol, and LPS and resveratrol. After the experiment, liver and kidney tissues were collected for histopathological evaluation, blood serums were collected to measure malondialdehyde levels with enyzme‐linked immunosorbent assay, and Toll‐like receptor‐4 (TLR4), tumor necrosis factor‐α (TNF‐α), nuclear factor‐κB (NF‐κB) immunoreactivity density was evaluated immunohistochemically. In addition, messenger RNA expression levels for TLR4, TNF‐α, NF‐κB, interleukin‐1β, and interleukin 6 were measured. In addition, the damage observed in liver and kidney tissue was determined by AgNOR (argyrophilic nucleolar organizer regions) staining. LPS application caused severe tissue damage, oxidative stress, and increased the expressions of proinflammatory proteins and genes we evaluated, while resveratrol application eliminated these negativities. Resveratrol has been proven to suppress the TLR4/NF‐κB/TNF‐α pathway, a possible therapeutic signaling pathway that is important in initiating the inflammatory response in an animal model of sepsis.
Effect of variation in starch B‐granule content in durum wheat on technological properties and in vitro starch digestion of spaghetti
Authors: Sissons Mike , Egan Narelle 
Published: March 2023

AbstractBackground and ObjectivesWhile there are a few studies examining the impact of isolated starch A and B granule preparations on cereal end product quality, there is limited information about the effect of genotypic variation in B granule content in starch on pasta technological properties and pasta in vitro starch digestion. Crosses were made between a durum variety Yallaroi and a low and high B‐granule dicoccoides accession and the resulting population evaluated in field trials for starch B‐granule content (S‐BG) and selections made for more detailed analysis.FindingsGenotypes were grouped based on semolina B granule contents of 24.5%−26.7%, 31.7%−37.1%, and 43.9%−45.1% for analysis purposes. Preliminary field data indicated three “43.9−45.1%” B‐granule genotypes had lower grain and test weight and one of these, 156,224*2, a very high semolina Buhler mill yield. Pasta made from the genotypes produced acceptable pasta but there was no association between S‐BG and pasta properties. To overcome protein composition differences between genotypes, starch was isolated and reconstituted flours and pasta prepared. Starch from the same “43.9−45.1%” group all showed RVA profiles with lower final viscosities and setback and displayed higher gelatinization onset and peak temperatures than the “24.5−26.7%” group. Pasta made from reconstituted flours showed similar pasta quality and in vitro starch digestion properties.ConclusionsThe data suggests no relationship between percentage of B‐granules and both pasta quality and starch digestion for the range and populations studied (S‐BG, 22%−44%).Significance and NoveltyThis information provides new insights into the role varying S‐BG content in pasta cooking properties, texture and nutritional characteristics and could provide some direction to breeders to consider breeding for very low or very high B‐granule content.
A rare case of drug sensitive adult‐onset temporal lobe epilepsy due to a focal cortical dysplasia revealed by ictal coughing: First report in sub‐Saharan Africa
Authors: Chokote Eric‐Samuel , Ngarka Leonard , Takoeta Emmanuel Oben , Kengni Hermann Nestor Tsague , Nfor Leonard N. , Mengnjo Michel K. , Mendo Edwige Laure , Djeutcheu Fabrice , Yepnjio Faustin N. , Tatah Godwin Y. , Mbassi Hubert Désiré Awa , Njamnshi Alfred K. 
Published: March 2023

AbstractThis case suggests that clinicians should consider seizures as a differential diagnosis of paroxystic cough with loss of consciousness. Focal cortical dysplasia should equally be screened for with magnetic resonance imaging (MRI) scans even in adults with epilepsy in sub‐Saharan Africa.
Case report: Per oral endoscopic myotomy (POEM) during pregnancy
Authors: Mejía Ricardo J. , Sáez Josefina , Quitral Ricardo A. , Monrroy Hugo A. , Belmar Cristian G. , Sharp Allan C. 
Published: March 2023

AbstractEsophageal achalasia is the most frequent primary motor disorder of the esophagus, resulting in a peristalsis and failed relaxation of the lower esophageal sphincter (LES). Various treatments have been described. Endoscopic alternatives include botulinum toxin injection and pneumatic balloon dilation, but both tend to fail with time and usually repeated interventions are required. Laparoscopic Heller myotomy (LHM) has been considered the gold standard. The diagnosis of achalasia during pregnancy is extremely rare and optimal management remains unclear. Our aim was to report a successful per oral endoscopic myotomy (POEM) performed during pregnancy. A 40‐year‐old pregnant woman presented with esophageal achalasia during her first trimester. Her disease was diagnosed with high resolution esophageal manometry (HREM). Initially an expectant conduct was attempted, but dysphagia progressed during the first 6 weeks of follow‐up and an important weight loss was noticed. She underwent POEM at 15 weeks of gestation. After the procedure, she reported relief of both dysphagia and regurgitation, and her nutritional status improved. She delivered a healthy boy at term. During follow‐up, she remains without dysphagia, her upper GI endoscopy shows no esophagitis and her HREM reports a normal integrated relaxation pressure. In achalasia, as in other clinical conditions, therapeutic decisions during pregnancy should always consider both the welfare of the mother and the fetus. POEM is a purely endoscopic treatment and has been recognized as a safe procedure to treat achalasia, with postoperative clinical success comparable to LHM and potential benefits over it.
Morphology Changes of Cu2O Catalysts During Nitrate Electroreduction to Ammonia**
Authors: Anastasiadou Dimitra , van Beek Yvette , Chen Wei , Wissink Tim , Parastaev Alexander , Hensen Emiel J. M , Costa Figueiredo Marta 
Published: March 2023

AbstractThis manuscript reports the electrosynthesis of ammonia from nitrate catalysed Cu derived from Cu2O materials. Cu2O (111) and (100) preferential grain orientations were prepared through electrodeposition. Cu derived from Cu2O (111) is more active and selective for ammonia formation than Cu2O (100) derived Cu. The highest faradaic efficiency (FE) was achieved for both catalysts at −0.3 V vs RHE, with Cu derived from Cu2O (111) reaching up to 80 %. Additional measurements with quasi‐in situ X‐ray photoelectron spectroscopy and in situ Raman spectroscopy revealed that Cu0 is the active phase during the reaction. The stability of the catalysts was examined by ex situ methods such as SEM, XRD and ICP elemental analysis. The catalysts underwent severe morphological changes as a function of the applied potential and the reaction time, most likely due to the dissolution and redeposition of Cu. After 3 hours of reaction, the entire surface of the catalysts was reconstructed into nanoneedles. The FE after 3 hours remained higher for the Cu derived from Cu2O (111), suggesting that the activity is dependent on the initial structure and the different rates of dissolution and re‐deposition.
Introducing Structural Diversity: Fe2(MoO4)3 Immobilized in Chitosan Films as an Efficient Catalyst for the Selective Oxidation of Sulfides to Sulfones
Authors: Libero Laura O. , Ribeiro Lara K. , Granone Luis I. , Churio Maria S. , Souza Josiane C. , Mastelaro Valmor R. , Andrés Juan , Longo Elson , Mascaro Lucia H. , Assis Marcelo 
Published: March 2023

AbstractThis work reports how the immobilization of Fe2(MoO4)3 in chitosan films affects the oxidation reaction of sulfide derivatives to sulfates in the dark, resulting in good yields and excellent selectivity. As demonstrated, a variety of substituted sulfides were tolerated even in the presence of oxidative‐sensitive functional groups, leading to a regioselective application of the catalyst under mild reaction conditions and guaranteeing its reuse for at least 6 cycles without losing its catalytic performance. Specifically, films containing 1 mg of Fe2(MoO4)3 per ml of chitosan showed a yield and selectivity of 99 %. The key success of the selective oxidation was associated with the presence of the hydroxyl radical, ⋅OH, and the Fe3+/Fe2+ Fenton‐like process. As a proof of concept, the selective oxidation of sulfides to the corresponding sulfones was performed to demonstrate the synergistic effect between Fe2(MoO4)3 and chitosan. This work offers a design strategy for efficient catalysts that may extend to other semiconductors and oxidation processes.
Self‐esteem and career adaptability: Moderating roles of parental and peer support
Authors: Kvasková Lucia , Hlado Petr , Juhaňák Libor , Macek Petr 
Published: March 2023

AbstractThe present study aimed to examine the long‐term associations between self‐esteem and career adaptability and to investigate the moderating roles of parental and peer support in these associations. The two‐wave longitudinal study used a sample of 3126 graduates from vocational upper secondary education during their career transition. Questionnaires were administered at two time points: 2 months before graduation (T1) and 10 months after graduation (T2). The results of linear regression and moderation analysis showed that (1) self‐esteem had a longitudinal positive effect on career adaptability, (2) perceived parental and peer support did not have significant effects on career adaptability, and (3) peer support served as a moderator in the relationship between self‐esteem and career adaptability. The findings emphasize the psychosocial nature of career adaptability and highlight the role of perceived peer support in the career adaptability of vocational education graduates during their career transition.
Optimization of Chromium(III) Sorption by Activated Sludge Using Response Surface Methodology
Authors: Benhammadi Samia , Aguedal Hakim , Ouazani Fouzia , Iddou Abdelkader , Sethi Sheetal , Goel Gaurav 
Published: March 2023

AbstractThe removal process of Cr(III) in aqueous solution using activated sludge as adsorbent was optimized. Response surface methodology was employed to assess the removal efficiency considering the cumulative effect of pH and contact time. The quantitative relationship between Cr(III) uptake and variable parameters was used to optimize the control level of each parameter by a full factorial design method. The analysis of variance demonstrates that the model was statistically highly significant, which shows also that the removal of Cr(III) was affected by the studied factors. The model was statistically tested and verified by experimentation. The response surface methodology gives not only valuable information on interactions between the evaluated parameters but also allows identifying the optimum values of the studied factors.
Quick prioritization of Cochrane reviews on benign conditions of the prostate
Authors: Franco Juan V. A. , Jung Jae H. , Dahm Philipp 
Published: March 2023

AbstractIntroductionBenign conditions of the prostate include benign prostatic enlargement and prostatitis, which constitute an important cause of morbidity in men.ObjectiveWe aimed to generate a list of priority topics of interest to our external stakeholders within our editorial scope.MethodsFollowing Cochrane's guidance, we developed a tiered approach for consulting internal and external stakeholders, including members from Urological societies. First, we analyzed our portfolio, including different impact measurements, to assess the need for updates. Then, following criteria related to the feasibility, novelty and relevance of prospective topics for evidence synthesis, we narrowed the list to a suite of titles for updates or new reviews.ResultsTwelve editors provided initial feedback as to what the priorities were for updating existing reviews and for new reviews in our portfolio. The editors identified gaps in our portfolio, mainly covering new treatments for benign prostatic hyperplasia. Then we consulted external stakeholders obtaining 30 responses from 14 countries. These stakeholders provided additional information about the relative importance of existing topics and suggested new ones. We identified that many of the latter were already covered in our portfolio, highlighting gaps in their dissemination. Finally, we narrowed down four priority topics that the editorial group will take forward and two additional topics that might need other considerations before being commissioned.ConclusionsFollowing Cochrane's guidance on priority setting, we identified topics relevant to our editors and external stakeholders by analysing our portfolio and two rounds of surveys. Moreover, we identified opportunities for disseminating existing reviews. Further evaluation is needed of the following up commissioning process for priority reviews.
Design of Fluorescent Carbon Dots (CDs) for the Selective detection of Metal‐Containing Ions
Authors: López‐Beltrán Alejandro , Iriarte‐Mesa Claudia , Murru Clarissa , Chao‐Mujica Frank J. , Corcho‐Valdés Angel Luis , Morales‐Álvarez Lisandra , Desdín‐García Luis Felipe , Deschamps Johnny , Antuch Manuel 
Published: March 2023

AbstractThe pollution caused by heavy metals (HMs) may occur through both natural processes and anthropogenic activities and is found in complex media. The purpose of this review is to summarize the state‐of‐art of fluorescent CDs and the sensing applications in a systematic manner. This review intends to provide clues on the origin on the observed selectivity in chemiluminiscence sensors, which was until now a stated but unaddressed question, and still remains open for debate. Indeed, it is tempting to think that CDs possessing functional groups with soft bases at the surface are able to detect soft metal acids, while the opposite is to be suspected for hard acid‐base pairs. However, the literature shows several examples where this trend does not hold. We found that such observation is explained by the involvement of dynamic quenching, which does not involve the formation of a non‐fluorescent complex, as in the case of static quenching. We have provided an interpretation of published data that was not provided by the original authors and offer guidelines to enable the design of CDs to target ions in solution.
Ruthenium Complexes of Polyfluorocarbon Substituted Terpyridine and Mesoionic Carbene Ligands: An Interplay in CO2 Reduction
Authors: Stein Felix , Nößler Maite , Hazari Arijit Singha , Böser Lisa , Walter Robert , Liu Hang , Klemm Elias , Sarkar Biprajit 
Published: March 2023

AbstractIn recent years terpyridines (tpy) and mesoionic carbenes (MIC) have been widely used in metal complexes. With the right combination with a metal center, both of these ligands are individually known to generate excellent catalysts for CO2 reduction. In this study, we combine the potentials of PFC (PFC=polyfluorocarbon) substituted tpy and MIC ligands within the same platform to obtain a new class of complexes, which we investigated with respect to their structural, electrochemical and UV/Vis/NIR spectroelectrochemical properties. We further show that the resulting metal complexes are potent electrocatalysts for CO2 reduction in which CO is exclusively formed with a faradaic efficiency of 92 %. A preliminary mechanistic study, including the isolation and characterization of a key intermediate is also reported.
Engineering the BASHY Dye Platform toward Architectures with Responsive Fluorescence
Authors: Felicidade João , Santos Fabio M. F. , Arteaga Jesús F. , Remón Patricia , Campos‐González René , Nguyen Ha‐Chi , Nájera Francisco , Boscá Francisco , Ng David Y. W. , Gois Pedro M. P. , Pischel Uwe 
Published: March 2023

AbstractA set of nine boronic‐acid‐derived salicylidenehydrazone (BASHY) complexes has been synthesized in good to very good chemical yields in a versatile three‐component reaction. In an extension to previous reports on this dye platform, the focus was put on the electronic modification of the “vertical” positions of the salicylidenehydrazone backbone. This enabled the observation of fluorescence quenching by photoinduced electron transfer (PeT), which can be reverted by the addition of acid in organic solvent (OFF‐ON fluorescence switching). The resulting emission is observed in the green‐to‐orange spectral region (maxima at 520–590 nm). In contrast, under physiological pH conditions in water, the PeT process is inherently decativated, thereby enabling the observation of fluorescence in the red‐to‐NIR region (maxima at 650–680 nm) with appreciable quantum yields and lifetimes. The latter characteristic supported the application of the dyes in fluorescence lifetime imaging (FLIM) of live A549 cells.
Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation
Authors: Gatzemeier Luisa Maria , Meyer Franc , Diederichsen Ulf , Outeiro Tiago Fleming 
Published: March 2023

AbstractAlpha‐Synuclein (α‐Synuclein) is a 140 amino acid protein implicated in neurodegenerative disorders known as synucleinopathies, where it accumulates in proteinaceous inclusions in the brain. The normal physiological function of α‐Synuclein remains obscure, as it exists in several non‐neuronal cells in which its function has not been studied. Given the tremendous interest in studying α‐Synuclein, and the existing limitations in the production of modified forms of the protein, we developed a method for the chemical synthesis of α‐Synuclein by combining peptide fragment synthesis via automated microwave‐assisted solid‐phase peptide synthesis and ligation strategies. Our synthetic pathway enables the synthesis of protein variants of interest, carrying either mutations or posttranslational modifications, for further investigations of the effects on the structure and aggregation behavior of the protein. Ultimately, our study forms the foundation for future syntheses and studies of other custom‐made α‐Synuclein variants with a single or several modifications, as necessary.