bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near‐Room‐Temperature Quasi‐Solid‐State F‐Ion Batteries with High Conversion Reversibility Based on Layered Structured Electrolyte
Authors: Yu Yifan , Lei Meng , Li Decheng , Li Chilin 
Published: January 2023

AbstractSolid‐state fluoride ion batteries (SSFIBs) are anion‐shuttle‐driven and alkali‐metal‐free emerging energy storage systems, and have the advantages of low cost, high safety, and energy density. However, the current major challenges of SSFIBs or quasi‐SSFIBs are the lack of high‐conductivity fluoride electrolytes and the difficulty of mild‐temperature operation of full cells. Here, a 2D fluoride conductor (KSn2F5) synthesized by mechanochemical method is employed as the compatible solid electrolyte with a high F‐ion conductivity of 10−4 S cm−1 at 60 °C. The high concentration and frequent hopping of charge carriers in F‐vacancy‐rich KSn2F5 contribute to the higher ionic conductivity compared to most reported fluoride structures. Integrating this layered electrolyte with high‐voltage CuF2 cathode and Sn/SnF2 anode, a highly reversible cycling of conversion‐type quasi‐SSFIBs with a discharge capacity of 150 mAh g−1 for at least 70 cycles at 60 °C is achieved. The interface engineering aided by tetra‐n‐butylammonium fluoride salt facilitates the F‐ion transfer between cathode and electrolyte and fluorination/defluorination conversion mechanism of CuF2 cathode with optimized multiphase and nanodomain distributions.
Enabling All‐Solid‐State Li Metal Batteries Operated at 30 °C by Molecular Regulation of Polymer Electrolyte
Authors: Wei Ying , Liu Te‐Huan , Zhou Wenjiang , Cheng Hang , Liu Xueting , Kong Jia , Shen Yue , Xu Henghui , Huang Yunhui 
Published: January 2023

AbstractThe low ionic conductivity of poly(ethylene oxide) (PEO)‐based polymer electrolytes at room temperature and the undesired lithium‐dendrite growth at Li|PEO interface impede their further application. Herein, a PEO polymer is regulated at the molecular level through a copper ion (Cu2+) coordination effect with both PEO and Li salts to achieve a high Li+ conductivity of 0.2 mS cm−1 and a transference number of 0.42 at 30 °C. Moreover, the Cu‐coordinated PEO electrolyte is neither sticky nor hygroscopic because the hydrophilic oxygen groups in PEO are terminated by Cu ions. Furthermore, the in situ formed F/Li‐rich inorganic layer induced by CuF2 additive accelerates Li+ transport kinetics and enables uniform Li+ deposition during Li plating/stripping. As a result, the Cu2+‐coordinated PEO electrolytes deliver a high critical current density of 1.5 mA cm−2 at 30 °C. An all‐solid‐state Li‐LiNi0.83Co0.12Mn0.05O2 (NCM83) battery with such a copper coordinated PEO electrolyte exhibits a long cycle life over 500 cycles with a capacity retention of 71% under 0.6 C at 30 °C. When the mass loading increases to a record high of 7 mg cm−2, the Li‐NCM83 cell delivers a high areal capacity of 1.07 mAh cm−2 under 0.1 C at 30 °C.
Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations
Authors: Roland Lauren T. , Humphreys Ian M. , Le Christopher H. , Babik Jennifer M. , Bailey Christopher E. , Ediriwickrema Lilangi S. , Fung Monica , Lieberman Joshua A. , Magliocca Kelly R. , Nam Hannah H. , Teo Neville W. , Thomas Penelope C. , Winegar Blair A. , Birkenbeuel Jack L. , David Abel P. , Goshtasbi Khodayar , Johnson Patricia G. , Martin Elaine C. , Nguyen Theodore V. , Patel Neil N. , Qureshi Hannan A. , Tay Kaijun , Vasudev Milind , Abuzeid Waleed M. , Hwang Peter H. , Jafari Aria , Russell Matthew S. , Turner Justin H. , Wise Sarah K. , Kuan Edward C. 
Published: January 2023

AbstractBackgroundAcute invasive fungal sinusitis (AIFS) is an aggressive disease that requires prompt diagnosis and multidisciplinary treatment given its rapid progression. However, there is currently no consensus on diagnosis, prognosis, and management strategies for AIFS, with multiple modalities routinely employed. The purpose of this multi‐institutional and multidisciplinary evidence‐based review with recommendations (EBRR) is to thoroughly review the literature on AIFS, summarize the existing evidence, and provide recommendations on the management of AIFS.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through January 2022. Studies evaluating management for orbital, non‐sinonasal head and neck, and intracranial manifestations of AIFS were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on management principles for AIFS were generated.ResultsA review and evaluation of published literature was performed on 12 topics surrounding AIFS (signs and symptoms, laboratory and microbiology diagnostics, endoscopy, imaging, pathology, surgery, medical therapy, management of extrasinus extension, reversing immunosuppression, and outcomes and survival). The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.
Photocatalytic Carboxylation of C−N Bonds in Cyclic Amines with CO2 by Consecutive Visible‐Light‐Induced Electron Transfer
Authors: Chen Lin , Qu Quan , Ran Chuan‐Kun , Wang Wei , Zhang Wei , He Yi , Liao Li‐Li , Ye Jian‐Heng , Yu Da‐Gang 
Published: January 2023

AbstractVisible‐light photocatalytic carboxylation with CO2 is highly important. However, it still remains challenging for reluctant substrates with low reduction potentials. Herein, we report a novel photocatalytic carboxylation of C−N bonds in cyclic amines with CO2 via consecutive photo‐induced electron transfer (ConPET). It is also the first photocatalytic reductive ring‐opening reaction of azetidines, pyrrolidines and piperidines. This strategy is practical to transform a variety of easily available cyclic amines to valuable β‐, γ‐, δ‐ and ϵ‐amino acids in moderate‐to‐excellent yields. Moreover, the method also features mild and transition‐metal‐free conditions, high selectivity, good functional‐group tolerance, facile scalability and product derivations. Mechanistic studies indicate that the ConPET might be the key to generating highly reactive photocatalysts, which enable the reductive activation of cyclic amines to generate carbon radicals and carbanions as the key intermediates.
Isoindolium‐Based Allenes: Reactivity Studies and Applications in Fluorescence Temperature Sensing and Cysteine Bioconjugation
Authors: O Wa‐Yi , Cui Jian‐Fang , Yu Qiong , Kung Karen Ka‐Yan , Chung Sai‐Fung , Leung Yun‐Chung , Wong Man‐Kin 
Published: January 2023

AbstractThe reaction of a series of electron‐deficient isoindolium‐based allenes with sulfhydryl compounds has been studied, leading to the formation of isoindolium‐based vinyl sulfides. The vinyl sulfides generated could be readily converted into the corresponding indanones and amines upon heating at 30–70 °C with good yields up to 61 %. The thermal cleavage reaction of vinyl sulfides was further studied for developing temperature‐sensitive systems. Notably, a novel FRET‐based fluorescent temperature sensor was designed and synthesized for temperature sensing at 50 °C, giving a 6.5‐fold blue fluorescence enhancement. Moreover, chemoselective bioconjugation of cysteine‐containing peptides with the isoindolium‐based allenes for the construction of multifunctional peptide bioconjugates was investigated. Thermal cleavage of isoindoliums on the modified peptides at 35–70 °C gave indanone bioconjugates with up to >99 % conversion. These results indicated the biocompatibility of this novel temperature‐sensitive reaction.
A Switchable Near‐Infrared‐Absorbing Dye Based on Redox‐Bistable Benzitetraazaporphyrin
Authors: Yanagi Shunsuke , Matsumoto Akihisa , Toriumi Naoyuki , Tanaka Yusuke , Miyamoto Kazunori , Muranaka Atsuya , Uchiyama Masanobu 
Published: January 2023

AbstractActivatable near‐infrared (NIR) dyes responsive to external stimuli are used in medical and other applications. Here, we describe the design and synthesis of bench‐stable 18π‐ and 20π‐electron benzitetraazaporphyrins (BzTAPs) possessing redox‐switchable NIR properties. X‐Ray, NMR, and UV/Visible‐NIR analyses revealed that 20π‐electron BzTAP 1 exhibits NIR absorption and antiaromaticity with a paratropic ring‐current, while 18π‐electron BzTAP 2 shows weakly aromatic character with NIR inertness. Notably, the NIR‐silent BzTAP 2 was readily converted to the NIR‐active BzTAP 1 in the presence of mild reducing agents such as amine. The intense NIR absorption band of BzTAP 1 is in sharp contrast to the very weak absorption bands of previously reported antiaromatic porphyrinoids. Molecular orbital analysis revealed that symmetry‐lowering perturbation of the 20π‐electron porphyrinoid skeleton enables the HOMO–LUMO transition of 1 to be electric‐dipole‐allowed. BzTAPs are expected to be useful for constructing activatable NIR probes working in reductive environments.
Preparation and surface modification of ultrahigh throughput tannic acid coblended polyethersulfone ultrafiltration membranes for hemodialysis
Authors: Zhang Zezhen , Feng Shuman , Wei Qianyu , Wu Lili 
Published: January 2023

AbstractLow dialysis and blood incompatibility efficiency are key issues to be addressed for polymeric hemodialysis membranes. To improve the comprehensive performance of hemodialysis membranes, polyethersulfone (PES)/tannic acid (TA) coblended ultrafiltration membranes were prepared and modified with a heparin‐like functionalized TA coating. The coblended TA improved the pore structure of the PES ultrafiltration membrane. And it could also undergo π‐π conjugation with the heparin‐like functionalized TA in the modified solution, resulting in a greater abundance of modified groups loaded on the membrane surface and pores close to the surface. The modified coating further improved the membrane performance. The physicochemical properties, solute filtration, and blood compatibility properties of the membrane were tested. The effect of TA on the pore structure of the membrane and the presence of modified layers were demonstrated by morphological and chemical structure analyses. The final modified membrane had an ultrahigh water flux (1053 L/m2·h), improved dialysis performance (BSA retention >99%, Lysozyme clearance >30% and Urea clearance >90%), and excellent hemocompatibility (The hemolysis rate was 1.31%, and APTT, PT, and TT values were increased by 40.8%, 74.2%, and 85.9%, respectively). This study shows that TA has great potential for improving the pore structure of polymeric membranes.
Effect of surface treatment on flax fiber reinforced natural rubber green composite
Authors: Samant Lata , Goel Alka , Mathew Jessen , Jose Seiko , Thomas Sabu 
Published: January 2023

AbstractThe present work is an attempt to study the effect of different surface treatments of flax fiber on the mechanical properties of the natural fiber reinforced natural rubber (NR) composites. In this study, flax fiber was chopped to 1, 1.25, and 1.5 cm in length and mixed with NR in two roll mill. The composite of 20%, 30%, 40%, and 50% fiber loading was prepared from each fiber length. Tensile analysis showed that a 1.25 cm fiber length composite of volume 40% has higher tensile strength compared to others. Hence, this optimized the fiber length and loading has opted for further study. Flax fiber was treated with NaOH and laccase and reinforced into an NR matrix. Properties like tensile strength, hardness, relative density, water diffusion, scanning electron microscope (SEM) and Fourier‐transform infrared spectroscopy (FTIR) for surface treated and untreated natural fiber‐reinforced NR composites have been investigated and compared. The reduction in the hydrophilic characteristics of the NaOH and laccase treated fiber was evident from FTIR analysis and increase in the crystallinity index of the fiber depicted by X‐ray diffraction (XRD) results. SEM analysis showed the enhanced interfacial interaction of treated flax fiber NR composite compared to untreated composite due to the removal of non‐cellulosic contents in fiber and an increase in the surface roughness after treatments. Further, an increase of 9% and 27.4% in tensile and tear strength was found in NaOH treated flax fiber reinforced NR composite.
High‐Performance Zinc‐Ion Battery Enabled by Tuning the Terminal Group and Chain Length of PEO‐based Oligomers
Authors: Yu Min , Zhao ShunShun , Xiao Ying , Zhang Ruixin , Liu Lili , Chen Shimou 
Published: January 2023

AbstractSide reactions and dendrite growth issues originated from free water seriously hamper the application of zinc‐ion batteries (ZIB). The electrolyte strategy of using a co‐solvent system has been proven to effectively improve the performance of ZIB. However, lack of thorough understanding of the co‐solvent structure on the performance of electrolytes hinders the rational design of co‐solvent electrolytes. Here, by studying how the terminal group and chain length of polyethylene oxide (PEO) based oligomers affect the electrochemical performance of ZIB, we obtained the optimized PEO oligomer structure and the underlying mechanism. As a result, the designed co‐solvent electrolyte enables the Zn|| NH4V4O10full cell to gain a 98.5 % capacity retention over 9500 cycles at 10 A g−1. This work provides new insights into the inhibition of water‐related side reactions and further promote the development of electrolytes for ZIB and other metal batteries.
Satisfied teachers are good teachers: The association between teacher job satisfaction and instructional quality
Authors: Harrison Mark G. , King Ronnel B. , Wang Hui 
Published: January 2023

AbstractInstructional quality is associated with better academic outcomes for students. This study aimed to investigate how teachers' job satisfaction was associated with clarity of instruction and cognitive activation as measures of instructional quality. In addition, we investigated whether this association between teachers' job satisfaction and instructional quality was mediated by teacher–student relationships. Drawing on the 2018 Teaching and Learning International Survey (TALIS), we compared participants from both Eastern (N = 27,106; Japan, Taipei, Korea, Shanghai) and Western sociocultural contexts (N = 20,209; Canada, Australia, New Zealand, United States, United Kingdom). Multilevel structural equation modelling results indicated that teachers' job satisfaction was positively associated with instructional quality across Eastern and Western settings. The relationship between teachers' job satisfaction and instructional quality was partially mediated by better student–teacher relationships. There were some differences between the cultural settings in how job satisfaction correlated with clarity of instruction and cognitive activation. We suggest that these differences may be accounted for by cultural characteristics leading to different approaches to teaching. Our results suggest that teachers' job satisfaction and the quality of classroom‐level relationships may be important indicators of positive instructional outcomes. While schools focus on student outcomes, they should also address teachers' job satisfaction and prioritise the importance of relationships between teachers and students in classrooms.
DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation
Authors: Macedo‐Silva Catarina , Constâncio Vera , Miranda‐Gonçalves Vera , Leite‐Silva Pedro , Salta Sofia , Lobo João , Guimarães Rita , Carvalho‐Maia Carina , Gigliano Davide , Farinha Mónica , Sousa Olga , Henrique Rui , Jerónimo Carmen 
Published: January 2023

AbstractBackgroundEsophageal cancer (ECa) is associated with high mortality, mostly due to late diagnosis, precluding curativeintent surgery. Hence, neoadjuvant chemoradiation (ChRT) is recommended in most patients regardless of histological subtype. A proportion of these patients, however, achieve complete disease remission and might be spared of radical surgery. The lack of reliable, minimally invasive biomarkers able to detect post‐ChRT disease persistence is, nonetheless, a major drawback. We have previously shown that miRNA promotor methylation enables accurate cancer detection in tissues and liquid biopsies but has been seldom explored in ECa patients.AimsHerein, we sought to unveil and validate novel candidate biomarkers able to detect ECa prior and post ChRT.Materials and MethodsPromoter methylation of miR129‐2, miR124‐3 and ZNF569 was assessed, using quantitative methylation‐specific PCR (qMSP), in tissue samples from normal esophagus, treatment‐naïve and post‐ChRT ECa, as well as in liquid biopsies from ECa patients.ResultsAll genes disclosed significantly different promoter methylation levels between ECa and normal esophagus, accurately detecting post‐ChRT disease, especially for adenocarcinoma. Remarkably, miR129‐2me/ZNF569me methylation panel identified ECa in liquid samples with 53% sensitivity and 87% specificity.DiscussionMiR129‐2me, miR124‐3me and ZNF569me accurately discriminate ECa, either pre‐ or post‐ChRT, from normal tissue, enabling ECa detection. Furthermore, circulalting methylation‐based biomarkers are promising minimally invasive tools to detect post‐ChRT residual ECa.ConclusionOverall, our results encourage the use of miRNA methylation biomarkers as accurate ECa detection tools as a novel approach for ChRT response monitoring.
Real time patient‐reported outcome measures in patients with cancer: Early experience within an integrated health system
Authors: Tam Samantha , Zatirka Theresa , Neslund‐Dudas Christine , Su Wan‐Ting , Cannella Cara E. , Grewal Jeewanjot S. , Mattour Ahmad H. , Tang Amy , Movsas Benjamin , Chang Steven S. 
Published: January 2023

AbstractBackgroundWhile patient‐reported outcome measures (PROMs) have benefit in cancer clinical trials, real‐world applications are lacking. This study describes the method of implementation of a cancer enterprise‐wide PROMs platform.MethodsAfter establishing a multispecialty stakeholder group within a large integrated health system, domain‐specific instruments were selected from the National Institutes of Health's Patient‐Reported Outcomes Measurement Information System (PROMIS) instruments (pain interference, fatigue, physical function, and depression) and were administered at varying frequencies throughout each patient's cancer journey. All cancer patients with an oncologic visit were eligible to complete the PROMs prior to the visit using a patient portal, or at the time of the visit using a tablet. PROMs were integrated into clinical workflow. Clinical partnerships were essential for successful implementation. Descriptive preliminary data were compared using multivariable logistic regression to determine the factors associated with method of PROMs completion.ResultsFrom September 16, 2020 to July 23, 2021, 23 of 38 clinical units (60.5%) implemented PROMs over 2392 encounters and 1666 patients. Approximately one third of patients (n = 629, 37.8%) used the patient portal. Black patients (aOR 0.70; 95% CI: 0.51–0.97) and patients residing in zip codes with higher percentage of unemployment (aOR: 0.07, 95% CI: 0.01–0.41) were among the least likely to complete PROMs using the patient portal.ConclusionsSuccessful system‐wide implementation of PROMs among cancer patients requires engagement from multispecialty stakeholders and investment from clinical partners. Attention to the method of PROMs collection is required in order to reduce the potential for disparities, such as Black populations and those residing in areas with high levels of unemployment.
Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas
Authors: Varadi Melinda , Nagy Nikolett , Reis Henning , Hadaschik Boris , Niedworok Christian , Modos Orsolya , Szendroi Attila , Ablat Jason , Black Peter C. , Keresztes David , Csizmarik Anita , Olah Csilla , Gaisa Nadine T. , Kiss Andras , Timar Jozsef , Toth Erika , Csernak Erzsebet , Gerstner Arpad , Mittal Vinay , Karkampouna Sofia , Kruithof de Julio Marianna , Gyorffy Balazs , Bedics Gabor , Rink Michael , Fisch Margit , Nyirady Peter , Szarvas Tibor 
Published: January 2023

AbstractObjectiveAdministration of targeted therapies provides a promising treatment strategy for urachal adenocarcinoma (UrC) or primary bladder adenocarcinoma (PBAC); however, the selection of appropriate drugs remains difficult. Here, we aimed to establish a routine compatible methodological pipeline for the identification of the most important therapeutic targets and potentially effective drugs for UrC and PBAC.MethodsNext‐generation sequencing, using a 161 cancer driver gene panel, was performed on 41 UrC and 13 PBAC samples. Clinically relevant alterations were filtered, and therapeutic interpretation was performed by in silico evaluation of drug‐gene interactions.ResultsAfter data processing, 45/54 samples passed the quality control. Sequencing analysis revealed 191 pathogenic mutations in 68 genes. The most frequent gain‐of‐function mutations in UrC were found in KRAS (33%), and MYC (15%), while in PBAC KRAS (25%), MYC (25%), FLT3 (17%) and TERT (17%) were recurrently affected. The most frequently affected pathways were the cell cycle regulation, and the DNA damage control pathway. Actionable mutations with at least one available approved drug were identified in 31/33 (94%) UrC and 8/12 (67%) PBAC patients.ConclusionsIn this study, we developed a data‐processing pipeline for the detection and therapeutic interpretation of genetic alterations in two rare cancers. Our analyses revealed actionable mutations in a high rate of cases, suggesting that this approach is a potentially feasible strategy for both UrC and PBAC treatments.
Furo[2,3‐d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study
Authors: Song Buer , Nie Lifei , Bozorov Khurshed , Niu Chao , Kuryazov Rustamkhon , Akber Aisa Haji , Zhao Jiangyu 
Published: January 2023

AbstractThe chemical transformation of the tricyclic furo[2,3‐d]pyrimidines was performed under isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine‐containing derivatives. Naturally‐occurring alkaloids mackinazolinone and isaindigotone were as templates of target heterocycles. Synthesized compounds evaluated for their antitumor activity on human cancer cervical HeLa, breast MCF‐7, and colon HT‐29 cell lines. Four compounds: 8c, 8e, 10b, and 10c demonstrated potency against HeLa and HT‐29 cell lines, and IC50 values were between 7.37–13.72 μM, respectively. The molecular docking results showed that compounds 8c and 10b had good binding and high matching with the target EGFR protein.
Negative effects of rivaroxaban observed in a patient with multiple common risks triggered by a bicycle accident
Authors: Abe Kurumi , Momo Kenji , Oto Yuji , Kida Masaki , Iwakiri Takuma , Tanaka Katsumi , Sasaki Tadanori 
Published: January 2023

AbstractThe negative effects of anticoagulants are well‐known in patients with renal impairment, drug–drug interaction, lower physical conditions, and multiple comorbidities. We highlight that even in patients with controllable multiple risks for rivaroxaban use, add‐on inevitable risks will lead to negative effects greater than those expected.