bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive and Psychiatric Relevance of Dynamic Functional Connectivity States in Children
Authors: Fu Zening , Sui Jing , Iraji Armin , Liu Jingyu , Calhoun Vince 
Published: January 2023

Abstract

Children’s brains dynamically adapt to the stimuli from the internal state and the external environment, allowing for changes in the cognitive and mental behavior of individuals. In this work, we performed a large-scale analysis of dynamic functional connectivity (DFC) in children aged 9 ~ 11 years, investigating how brain dynamics relate to cognitive performance and mental health during an early age. An adaptive independent component analysis framework was applied to the Adolescent Brain Cognitive Development (ABCD) data containing 10,988 children. We combined a sliding-window approach with k-means clustering to identify five reoccurring brain states with distinct DFC patterns. Interestingly, the occurrence of a strongly connected state was negatively correlated with cognitive performance and positively correlated with dimensional psychopathology in children. Meanwhile, the opposite relationships were observed for a sparsely connected state. The composite scores, the attention score, and the Attention-Deficit/Hyperactivity Disorder score were the most significantly correlated with the DFC states. The cognitive and psychiatric relevance of DFC states were highly reproducible across scans and between longitudinal sessions. Finally, the mediation analysis showed that the attention problems mediate the effect of DFC states on cognitive performance. This investigation unveils the neurological underpinnings of DFC by highlighting their robust associations with behavioral development in childhood. Tracking the patterns of maturation in DFC states may capture delays in development and guide people to provide early intervention to buffer adverse influences in children’s development.
Is there a Subnational Resource Curse? Evidence from Households in the Niger Delta Region of Nigeria
Authors: Animashaun Jubril , Emediegwu Lotanna 
Published: January 2023

Abstract
The local effect of extractive industries on households’ living standards is viewed in this study as a signal of non-homothetic preferences for education. Previous evidence suggests that resource booms have a positive effect on labor outcomes that further translate into a reduction of poverty in the local population. In contrast to artisanal mining, hydrocarbon-based industries are intensive in high-skilled labor; we predict that further development could increase investment in education but have ambiguous implications on demand in sectors that improve the local welfare. Using annual household data from the Niger Delta between 2010 to 2016, we employ a geographic triple–differences (DDD) estimation that exploits spatial and temporal variation in oil production and locations. We find that costs of living are higher by proximity to oil fields but find that the mechanism is via non-homothetic preferences for education. We find inconclusive evidence on other welfare indicators; limited employment opportunities in non-oil sectors may explain the weak backward linkages and potential positive spillovers. JEL Codes: O13, O18, Q32, J24, I2, R20
Proteomics‑based prognostic signature predicts prognosis and immunity in glioma
Authors: xinyu shen , Zhou Jue , Tan Haoyuan , Zhao Dongxu , Lan Jin , Guo Han , Bao Yinghui 
Published: January 2023

Abstract
The prognosis of glioma patients is closely associated with the expression of immune cells and oncoproteins. Therefore, protein-related signatures were conducted to improve the prediction of overall survival (OS) in glioma patients after surgery. Differential oncoproteins were selected from the Renji cohort and The Cancer Genome Atlas (TCGA) database. The least absolute shrinkage and selection operator (LASSO) regression model is designed to construct the multiple oncoprotein model related to OS in two test series. Furthermore, the 6-oncoprotein model was tight associated with immune cell infiltration, immune function, and immunotherapy. In summary, the 6-oncoprotein marker, a favorable biomarker for the prognosis and immune characteristics of glioma, could help individualized immunotherapy for patients with glioma.
Foam mat drying of Indian blackberry (Syzygium cuminii L.) fruit pulp: Optimization of process parameters and its powder characteristics
Authors: Sahu Indrajeet , Mohapatra Minati , Panda Manoj Kumar , Nayak Raghabananda , Pal Uma Sankar , Rayaguru Kalpana , Dash S.K. 
Published: January 2023

Abstract
Foam-mat drying of Indian black-berry pulp (Syzygiumcumini L.) was carried out using different foaming aids, to determine the effects of concentration of maltodextrin (MD), soy protein isolate (SPI) and carboxymethylcellulose (CMC) on foaming characteristics e.g. foam expansion (FE), foam stability (FS) and foam density (FD). Optimization of product ingredients were performed using three levels of MD (3.0, 5.0, and 7.0 %), SPI (0.5, 1.0, and 1.5 %) and CMC (0.0, 1.0, and 2.0 %) using Box-Behnken method of response surface design. The optimum solutions of the process parameters were obtained at 5.47% of MD, 1.02% of SPI and 1.06% of CMC with response functions of 93.93% FE, 91.60% FS and 481.71 kg/m3 FD. The optimised foamed jamun pulp was dried using hot air-drying method at temperature of 50, 60 and 70°C. The drying rate and effective moisture diffusivity (8.978×10-11 to 1.246×10-10 m2/s) increased with increase in drying temperature. The powder characteristics of dried jamun pulp including bulk density (0.15 to 0.12), flowability: HR (1.27 to 1.13) and CI (21.28 to 12.26 %), total anthocyanin content (61.06 to 35.63 mg/100g) and total phenolic content (278.49 to 195.78 mg GAE/100g) were reduced as the drying air temperature increased from 50 to 70° C, however water solubility index (58.55 to 74.28 %) and hygroscopicity (12.43 to 14.22 g/100g) of powder increased. The dried powder had a porous microstructure and yield medium brightness to their colour.
Effectiveness and Cost-Effectiveness of a Personalised Self-management Intervention for living with long COVID: protocol for the LISTEN randomised controlled trial
Authors: Potter Claire , Leggat Fiona , Lowe Rachel , Pallmann Philip , Riaz Muhammad , Barlow Christy , Edwards Adrian , Siriwardena Aloysius Niroshan , Sevdalis Nick , Sewell Bernadette , McRae Jackie , Fish Jessica , de Abreu Maria Ines de Sousa , Jones Fiona , Busse Monica 
Published: January 2023

Abstract
Background.
Individuals living with long COVID experience multiple, interacting and fluctuating symptoms which can have a dramatic impact on daily living. The aim of the Long Covid Personalised Self-managemenT support EvaluatioN (LISTEN) trial is to evaluate effects of the LISTEN co-designed self-management support intervention for non-hospitalised people living with long COVID on participation in routine activities, social participation, emotional well-being, quality of life, fatigue, and self-efficacy. Cost-effectiveness will also be evaluated, and a detailed process evaluation carried out to understand how LISTEN is implemented.
Methods.
The study is a pragmatic randomised effectiveness and cost-effectiveness trial in which a total of 558 non-hospitalised people with long COVID will be randomised to either the LISTEN intervention or usual care. Recruitment strategies have been developed with input from the LISTEN Patient and Public Involvement and Engagement (PPIE) advisory group and a social enterprise, Diversity and Ability, to ensure inclusivity. Eligible participants can self-refer into the trial via a website or be referred by long COVID services. All participants complete a range of self-reported outcome measures, online, at baseline, 6 weeks, and 3 months post randomisation (the trial primary end point). Those randomised to the LISTEN intervention are offered up to six one-to-one sessions with LISTEN trained intervention practitioners and given a co-designed digital resource and paper-based book. A detailed process evaluation will be conducted alongside the trial to inform implementation approaches should the LISTEN intervention be found effective and cost-effective.
Discussion.
The LISTEN trial is evaluating a co-designed, personalised self-management support intervention (the LISTEN intervention) for non-hospitalised people living with long COVID. The design has incorporated extensive strategies to minimise participant burden and maximise access. Whilst the duration of follow-up is limited, all participants are approached to consent for long term follow-up (subject to additional funding being secured).
Trial Identifier: LISTEN, Trial registration: ISRCTN36407216, registered 27/01/2022
Magmatic Surge Requires Two-Stage Model for the Laramide Orogeny
Authors: Schwartz Joshua , Lackey Jade Star , Miranda Elena , Klepeis Keith , Mora-Klepeis Gabriela , Robles Francine , Bixler Jonathan 
Published: January 2023

Abstract
The beginning of the Laramide orogeny is a pivotal time in the geological development of the western United States, but the driving mechanism responsible for mountain building, basin formation and ore mineralization is controversial. Most prominent models suggest this event was caused by the collision of an oceanic plateau with western North America at ca. 88 Ma which caused the angle of subduction beneath the continent to shallow. This subhorizontal (flat) subduction is thought to have led to shut-down of the arc, crustal cooling, and the formation of deep, basement-involved thrust faults that penetrated far into the continental interior. In contrast to these predictions, we show that the arc experienced a magmatic surge, the lower crust was hot (835-750°C) and partially molten from 90 to 70 Ma, and cooling occurred after 75 Ma. These data contradict plateau underthrusting as the driving mechanism at 90-80 Ma; therefore, the Laramide orogeny cannot have been initiated by flat-slab subduction. We propose that the Laramide orogeny is best explained as a two-stage orogeny consisting of a syn-magmatic phase at 90-75 Ma, and a widespread mountain building phase at 75-50 Ma. Only that latter phase is linked to flat-slab subduction.
A Novel Index for measuring the Impact of Devices on Hypertension: The Hypertensive Index
Authors: Kingsmore David B , Edgar Ben , Rostron Maggie , Delles Christian , Brady Adrian JB 
Published: January 2023

Abstract
A key limitation in assessing the therapeutic impact of non-pharmacological approaches to treating hypertension is the method of reporting outcomes. Reducing the medications required to achieve the same blood pressure may be reported separately to a reduction in the blood pressure without change in medication, and thus lessen the reported beneficial impact of treatment. This study aims to derive a novel scoring system to gauge the therapeutic impact of non-drug treatment of hypertension by utilising a combination of excessive blood pressure and the number of anti-hypertensives into a combined score - the hypertensive index (HTi). The hypertensive index was empirically derived based on the systolic blood pressure and number of antihypertensive drugs, and applied retrospectively to a cohort undergoing intervention for renovascular hypertension. Subgroup and receiver operating characteristic analyses were used to compare the HTi to traditional methods of reporting outcomes. 99 patients were included. Following intervention, 46% had improvement in both medication load and blood pressure, 29% had benefit in blood pressure without reduction in medication load, 15% had reduction in medication load without significant change in blood pressure and 9% showed no benefit in either parameter. The HTi was superior in detecting benefit from intervention compared with measuring blood pressure or medication load alone (AUC 0.94 vs 0.85;0.84). The hypertensive index may be a more sensitive marker of treatment effect than assessing blood pressure measurements alone. The use of such scoring systems in future trial design may allow more accurate reporting of the effects of interventions for hypertension.
Role of Pseudomonas fluorescens FSYZ01 on the Corrosion Behavior of Q235B Carbon Steel in Oilfield Produced Water
Authors: Liang Lihua , Ren Yuanyuan , Tian Yuan , Garcí José Alberto Alvarado , Zhang Pu , Zhu Xiaoli 
Published: January 2023

Abstract
The corrosion behavior of Q235B carbon steel is investigated in water, LB medium and oilfield produced water adding Pseudomonas fluorescens FSYZ01. After immersion for 13-days, weight loss of carbon steel with this strain decreased by 32.23%, 54.07%, and 78.34% respectively. XRD results show Pseudomonas fluorescens FSYZ01 inhibited conversion of iron oxides by hindering oxygen from approaching metal surface. FT-IR and XPS results show that specific functional groups and bonds reacted with Fe(II/III) to form a dense and stable chelate-oxide protective layer, thereby inhibiting corrosion. Py-GCMS results demonstrate the bacteria degraded C12 to C20 alkanes in oil. The inhibitory mechanism of crude oil degrading bacteria Pseudomonas fluorescens FSYZ01 on the carbon steel corrosion was proposed, so as to slowing corrosion of oilfield produced water system pipeline and prolonging its service life, helping to comprehend the microbial corrosion in the actual environment.
Combined in vivo and in situ genome-resolved metagenomics reveals novel symbiotic nitrogen fixing interactions between non-cyanobacterial diazotrophs and microalgae
Authors: CHANDOLA UDITA , TROTTIER CAMILLE , GAUDIN MARINNA , MANIRAKIZA ERIC , MENICOT SAMUEL , LOUVET ISABELLE , LACOUR THOMAS , CHAUMIER TIMOTHEE , TANAKA ATSUKO , Chaffron Samuel , Tirichine Leila 
Published: January 2023

Abstract
Non-cyanobacteria diazotrophs (NCDs) were shown to dominate in surface waters shifting the long-held paradigm of cyanobacteria dominance and raising fundamental questions on how these putative heterotrophic bacteria thrive in sunlit oceans. Here, we report an unprecedented finding in the widely used model diatom Phaeodactylum tricornutum (Pt) of NCDs sustaining diatom cells in the absence of bioavailable nitrogen. We identified PtNCDs using metagenomics sequencing and detected nitrogenase gene in silico and/or by PCR. We demonstrated nitrogen fixation in PtNCDs and their close genetic affiliation with NCDs from the environment. We showed the wide occurrence of this type of symbiosis with the isolation of NCDs from other microalgae, their identification in the environment, and predicted their associations with photosynthetic microalgae. Overall, this study provides evidence for a previously overlooked symbiosis using a multidisciplinary model-based approach, which will help understand the different players driving global marine nitrogen fixation.
Distinct mutational pattern of T-cell large granular lymphocyte leukemia combined with pure red cell aplasia: Low mutational burden of STAT3
Authors: Park Sooyong , Yun Jiwon , Choi Sung Yoon , Jeong Dajeong , Gu Ja-Yoon , Lee Jee-Soo , Seong Moon-Woo , Chang Yoon Hwan , Yun Hongseok , Kim Hyun Kyung 
Published: January 2023

Abstract
T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell aplasia (PRCA). A high depth of next generation sequencing (NGS) was used for detection of the mutational profiles in T-LGL alone (n = 25) and T-LGL combined with PRCA (n = 16). Beside STAT3 mutation (41.5%), the frequently mutated genes included KMT2D (17.1%), TERT (12.2%), SUZ12 (9.8%), BCOR (7.3%), DNMT3A (7.3%), and RUNX1 (7.3%). Mutations of the TERT promoter showed a good response to treatment. Concomitant myelodysplastic syndrome (MDS) was detected in 7.3%. T-LGL combined with PRCA showed unique features (low VAF level of STAT3 mutation, low lymphocyte count, old age). Low ANC was detected in a STAT3 mutant with a low level of VAF, suggesting that even the low mutational burden of STAT3 is sufficient for reduction of ANC. In retrospective analysis of 591 patients without T-LGL, one MDS patient with STAT3 mutation was revealed to have subclinical T-LGL. T-LGL combined with PRCA may be classified as unique subtype of T-LGL. High depth NGS can enable sensitive detection of concomitant MDS in T-LGL. Mutation of the TERT promoter may indicate good response to treatment of T-LGL, thus, its addition to an NGS panel may be recommended.
Novel Arterial Reconstruction Policy in Simultaneous pancreas-kidney Transplantation; A randomized clinical trial
Authors: Karar Hassan , Shafiekhani Mojtaba , Mahmoudi Mohamad Mahdi , Azadeh Nazanin , Shamsaeefar Alireza , Nazari Sahar Sohrabi , Jafari Mehran , Ashrafzadeh Kiarash , Esmaeili Maryam , Nikeghbalian Saman , Nikoupour Hamed 
Published: January 2023

Abstract
Introduction
Simultaneous pancreas kidney (SPK) transplantation is an inestimable procedure to enhance the quality of life of insulin-dependent patients with advanced renal disease. The creation of vascular anastomoses of the donor’s pancreas vessels to the recipient’s, is of utmost importance to predict the graft prognosis and surgical complications. In the study we introduce a novel technique for arterial reconstruction during SPK transplantation.
Methods
Conventionally, during the SPK transplantation, a so-called Y-graft is anastomosed between donor’s superior mesenteric and splenic artery to the recipient’s right iliac artery. In the study we adopted a new technique by preparing an extra extension using the donor’s carotid artery, to be anastomosed to the Y-graft and the iliac artery. In this non-blinded randomized clinical trial we compared the surgical complications and early outcomes between the 2 groups of patients with the traditional and new arterial reconstruction techniques during 3 months after transplantation
Results
Thirty adult patients were included in the study. The incidence of pancreatitis, vascular thrombosis and surgical site infection was lower in the new Y-graft and extension technique, which was not statistically significant. However, the calculated Cohen’s d index showed the medium effect of new Y-graft and extension technique on complication after SPK transplantations.
Conclusion
The post-operative complications tend to be lower in the novel arterial reconstruction technique, however a study on a larger patient group is encouraged to confirm our primary results.
Trial registration:
The study was registered at the Iranian Registry of Clinical Trials on 12/05/2022; IRCT 20210625051701N2; (http://www.irct.ir/).
Population screening for 15q11-q13 duplications: corroboration of the difference in impact between maternally and paternally inherited alleles
Authors: Vermeesch Joris , Parijs Ilse , Brison Nathalie , Vancoillie Leen , Janssens Katrien , Blaumeiser Bettina , Baetens Machteld , Janssens Sandra , Menten Björn , Dimitrov Boyan , Fieremans Nathalie , Kim Van Berkel , Bogaert Ann Van Den , MEUNIER Colombine , Désir Julie , Boulanger Sebastien , Marichal Axel , Devriendt Koenraad , Bogaert Kris Van den 
Published: January 2023

Abstract
Maternally inherited 15q11-q13 duplications are generally found to cause more severe neurodevelopmental anomalies compared to paternally inherited duplications. However, this assessment is mainly inferred from the study of patient populations, causing an ascertainment bias. Here, we analyze the low coverage genome-wide cell-free DNA sequencing data obtained from pregnant women during non-invasive prenatal screening (NIPS). We detect 23 15q11-q13 duplications in 333,187 pregnant women (0.0069%), with an approximately equal distribution between maternal and paternal duplications. Maternally inherited duplications are always associated with a clinical phenotype (ranging from mild learning difficulties to intellectual impairment, epilepsy and psychiatric disorders), while paternal duplications are associated with milder phenotypes (from normal to learning difficulties and dyslexia). This data corroborates the difference in impact between paternally and maternally inherited 15q11-q13 duplications, contributing to the improvement of genetic counselling. We recommend reporting 15q11-q13 duplications identified during genome-wide NIPS with appropriate genetic counselling for these pregnant women in the interest of both mothers and future children.
Topological transitions, turbulent-like motion and long-time-tails driven by cell division in biological tissues
Authors: Li Xin , Sinha Sumit , Kirkpatrick Theodore R. , Thirumalai Dave 
Published: January 2023

Abstract
The complex spatiotemporal flow patterns in living tissues, driven by active forces, have many of the characteristics associated with inertial turbulence even though the Reynolds number is extremely low. Analyses of experimental data from two- dimensional epithelial monolayers in combination with agent-based simulations show that cell division and apoptosis lead to directed cell motion for hours, resulting in rapid topological transitions in neighboring cells. These transitions in turn generate both long ranged and long lived clockwise and anticlockwise vortices, which gives rise to turbulent-like flows. Both experiments and simulations show that at long wavelengths the wave vector (k) dependent energy spectrum E(k) ≈ k−5/3, coinciding with the Kolmogorov scaling in fully developed inertial turbulence. Using theoretical arguments and simulations, we show that long-lived vortices lead to long-time tails in the velocity auto-correlation function, Cv(t) ∼ t−1/2, which has the same structure as in classical 2D fluids but with a different scaling exponent.
The synergistic response of primary production in grasslands to combined nitrogen and phosphorus addition is caused by increased nutrient uptake and retention
Authors: Vázquez Eduardo , Borer Elizabeth T. , Bugalho Miguel N. , Caldeira Maria C. , McCulley Rebecca L. , Risch Anita C. , Seabloom Eric W. , Wheeler George R. , Spohn Marie 
Published: January 2023

Abstract
Background and aims: A synergistic response of aboveground plant biomass production to combined nitrogen (N) and phosphorus (P) addition has been observed in many ecosystems, but the underlying mechanisms and their relative importance are not well known. We aimed at evaluating several mechanisms that could potentially cause the synergistic growth response, such as changes in plant biomass allocation, increased N and P uptake by plants, and enhanced ecosystem nutrient retention.
Methods: We studied five grasslands located in Europe and the USA that are subjected to an element addition experiment composed of four treatments: control (no element addition), N addition, P addition, combined NP addition.
Results: Combined NP addition increased the total plant N stocks per unit area by 1.47 times compared to the N treatment, while total plant P stocks per unit area were 1.62 times higher in NP than in single P addition. Further, higher N uptake by plants in response to combined NP addition was associated with reduced N losses from the soil (evaluated based on soil δ15N) compared to N addition alone, indicating a higher ecosystem N retention. In contrast, the synergistic growth response was not associated with significant changes in plant resource allocation.
Conclusions: Our results demonstrate that the commonly observed synergistic effect of NP addition on aboveground biomass production in grasslands is caused by enhanced N uptake compared to single N addition, and increased P uptake compared to single P addition, which is associated with a higher N and P retention in the ecosystem.