bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pattern of the heart rate performance curve in maximal graded treadmill running from 1100 healthy 18–65 Years old men and women: the 4HAIE study
Authors: Birnbaumer Philipp , Dostal Tomas , Cipryan Lukas , Hofmann Peter 
Published: May 2023

Introduction: The heart rate performance curve (HRPC) in maximal incremental cycle ergometer exercise demonstrated three different patterns such as downward, linear or inverse versions. The downward pattern was found to be the most common and therefore termed regular. These patterns were shown to differently influence exercise prescription, but no data are available for running. This study investigated the deflection of the HRPC in maximal graded treadmill tests (GXT) of the 4HAIE study.Methods: Additional to maximal values, the first and second ventilatory thresholds as well as the degree and the direction of the HRPC deflection (kHR) were determined from 1,100 individuals (489 women) GXTs. HRPC deflection was categorized as downward (kHR &lt; −0.1), linear (−0.1 ≤ kHR ≤ 0.1) or inverse (kHR &gt; 0.1) curves. Four (even split) age- and two (median split) performance-groups were used to investigate the effects of age and performance on the distribution of regular (= downward deflection) and non-regular (= linear or inverse course) HR curves for male and female subjects.Results: Men (age: 36.8 ± 11.9 years, BMI: 25.0 ± 3.3 kg m−2, VO2max: 46.4 ± 9.4 mL min−1. kg−1) and women (age: 36.2 ± 11.9 years, BMI: 23.3 ± 3.7 kg m−2, VO2max: 37.4 ± 7.8 mL min−1. kg−1) presented 556/449 (91/92%) downward deflecting, 10/8 (2/2%) linear and 45/32 (7/6%) inverse HRPC´s. Chi-squared analysis revealed a significantly higher number of non-regular HRPC´s in the low-performance group and with increasing age. Binary logistic regression revealed that the odds ratio (OR) to show a non-regular HRPC is significantly affected by maximum performance (OR = 0.840, 95% CI = 0.754–0.936, p = 0.002) and age (OR = 1.042, 95% CI = 1.020–1.064, p &lt; 0.001) but not sex.Discussion: As in cycle ergometer exercise, three different patterns for the HRPC were identified from the maximal graded treadmill exercise with the highest frequency of regular downward deflecting curves. Older subjects and subjects with a lower performance level had a higher probability to show a non-regular linear or inverted curve which needs to be considered for exercise prescription.
Cadmium exposure is associated with increased transcript abundance of multiple heavy metal associated transporter genes in roots of hemp (Cannabis sativa L.)
Authors: Marabesi Amanda O. , Nambeesan Savithri U. , van Iersel Marc W. , Lessl Jason T. , Coolong Timothy W. 
Published: May 2023

Industrial hemp (Cannabis sativa L.) has demonstrated promise for phytoremediation due to an extensive root system, large biomass, and ability to survive under relatively high levels of heavy metals. However, little research has been conducted to determine the impact of heavy metal uptake in hemp grown for medicinal use. This study evaluated the potential for cadmium (Cd) uptake and its impact on growth, physiological responses, and transcript expression of metal transporter genes in a hemp variety grown for flower production. The cultivar ‘Purple Tiger’ was exposed to 0, 2.5, 10, and 25 mg·L-1 Cd in a greenhouse hydroponic study in two independent experiments. Plants exposed to 25 mg·L-1 Cd displayed stunted plant growth characteristics, reduced photochemical efficiency, and premature senescence suggesting Cd toxicity. At the two lower concentrations of Cd (2.5 and 10 mg·L-1 Cd), plant height, biomass, and photochemical efficiency were not affected, with chlorophyll content index (CCI) being slightly lower at 10 mg·L-1 Cd, compared to 2.5 mg·L-1 Cd. There were no consistent differences between the two experiments in total cannabidiol (CDB) and tetrahydrocannabinol (THC) concentrations in flower tissues at 2.5 and 10 mg·L-1 Cd, compared to the control treatment. Root tissue accumulated the highest amount of Cd compared to other tissues for all the Cd treatments, suggesting preferential root sequestration of this heavy metal in hemp. Transcript abundance analysis of heavy metal-associated (HMA) transporter genes suggested that all seven members of this gene family are expressed in hemp, albeit with higher expression in the roots than in the leaves. In roots, CsHMA3 was up-regulated at 45 and 68 d after treatment (DAT), and CsHMA1, CsHMA4, and CsHMA5 were upregulated only under long term Cd stress at 68 DAT, at 10 mg·L-1 Cd. Results suggest that expression of multiple HMA transporter genes in the root tissue may be upregulated in hemp exposed to 10 mg·L-1 Cd in a nutrient solution. These transporters could be involved in Cd uptake in the roots via regulating its transport and sequestration, and xylem loading for long distance transport of Cd to shoot, leaf, and flower tissues.
Self-efficacy, organizational commitment, workload as predictors of life satisfaction in elementary school teachers: the mediating role of job satisfaction
Authors: Cayupe Juan C. , Bernedo-Moreira David Hugo , Morales-García Wilter C. , Alcaraz Fátima López , Peña Karla Berenice Carrazco , Saintila Jacksaint , Flores-Paredes Alcides 
Published: May 2023

BackgroundLife satisfaction as well as job satisfaction of teachers has a significant impact on educational outcomes.ObjectiveTo evaluate a model of factors predicting life satisfaction through the mediating role of job satisfaction.MethodsThis was a cross-sectional study, with a sample of 300 primary school teachers of both sexes (68% female, 32% male) and with a mean age of 42.52 years (SD = 10.04). They were administered the General Self-Efficacy Scale, the Satisfaction with Life Scale (SWLS), the Workload Scale (ECT), the Generic Job Satisfaction Scale, and the Organizational Commitment Questionnaire (OCQ). Structural equation modeling (SEM) was used for data analysis.ResultsThe SEM analysis found significant goodness-of-fit indices: (χ2 = 13.739; df = 5; p = &lt;0.001; CFI = 0.99, TLI = 0.98, RMSEA = 0.05, SRMR = 0.04). Specifically, self-efficacy and organizational commitment were positive predictors of job satisfaction, while workload was a negative predictor of job satisfaction. The mediating effect of job satisfaction between self-efficacy, life satisfaction, workload, and overall life satisfaction was confirmed.ConclusionThe results confirm the importance of self-efficacy, organizational commitment, and workload in job satisfaction and overall life satisfaction of elementary education teachers. Job satisfaction acts as a mediator in this relationship. It is important to reduce workload and promote self-efficacy and organizational commitment to improve the well-being and satisfaction of teachers.
Relationship between child-to-parent violence and cumulative childhood adversity: the mediating role of parental attachment, resilience, and emotional intelligence
Authors: Navas-Martínez María J. , Cano-Lozano M. Carmen 
Published: May 2023

IntroductionRecent research on aggressor profiles in child-to-parent violence (CPV) seems to provide promising results. However, this phenomenon has been poorly addressed in the adverse childhood experiences (ACEs) framework. This study aimed to explore the frequency of different types of ACEs and cumulative ACEs in adolescents who exert CPV, to analyze the differences between aggressors with different levels of cumulative ACEs in parental attachment, resilience, and emotional intelligence, and to evaluate the associations between these variables, as well as a possible mediational model.MethodsA total of 3,142 Spanish adolescents (50.7% girls) aged between 12 and 18 years from educational centers participated.ResultsAdolescents who exerted CPV presented higher rates of ACEs both independently and cumulatively than those without CPV. Aggressors with cumulative ACEs (88%) in general presented more insecure parental attachment, lower resilience, and lower emotional intelligence than those without cumulative ACEs, and, in turn, aggressors with high levels of cumulative ACEs than those with low levels of cumulative ACEs. Significant associations were identified between CPV, ACEs, insecure parental attachment, resilience, and emotional intelligence. The mediation model suggested that ACEs are related to CPV through preoccupied and traumatized parental attachment and also through low levels of emotional intelligence.DiscussionThe findings provide a better understanding of CPV from the perspective of ACEs, especially of those cases that involve an accumulation of adverse experiences during childhood, and suggest greater professional attention to these cases with the design of specialized CPV intervention programs.
Clinical profiling of specific diagnostic subgroups of women with chronic pelvic pain
Authors: Demetriou Lysia , Krassowski Michal , Abreu Mendes Pedro , Garbutt Kurtis , Vitonis Allison F. , Wilkins Elizabeth , Coxon Lydia , Arendt-Nielsen Lars , Aziz Qasim , Birch Judy , Horne Andrew W. , Hoffman Anja , Hummelshoj Lone , Lunde Claire E. , Meijlink Jane , Perro Danielle , Rahmioglu Nilufer , Terry Kathryn L. , Pogatzki-Zahn Esther , Sieberg Christine B. , Treede Rolf-Detlef , Becker Christian M. , Cruz Francisco , Missmer Stacey A. , Zondervan Krina T. , Nagel Jens , Vincent Katy 
Published: May 2023

IntroductionChronic pelvic pain (CPP) is a common condition affecting up to 26.6% of women, with many suffering for several years before diagnosis and/or treatment. Its clinical presentation is varied and there are frequently comorbid conditions both within and outside the pelvis. We aim to explore whether specific subgroups of women with CPP report different clinical symptoms and differing impact of pain on their quality of life (QoL).MethodsThe study is part of the Translational Research in Pelvic Pain (TRiPP) project which is a cross-sectional observational cohort study. The study includes 769 female participants of reproductive age who completed an extensive set of questions derived from standardised WERF EPHect questionnaires. Within this population we defined a control group (reporting no pelvic pain, no bladder pain syndrome, and no endometriosis diagnosis, N = 230) and four pain groups: endometriosis-associated pain (EAP, N = 237), interstitial cystitis/bladder pain syndrome (BPS, N = 72), comorbid endometriosis-associated pain and BPS (EABP, N = 120), and pelvic pain only (PP, N = 127).ResultsClinical profiles of women with CPP (13–50 years old) show variability of clinical symptoms. The EAP and EABP groups scored higher than the PP group (p &lt; 0.001) on the pain intensity scales for non-cyclical pelvic pain and higher than both the BPS and PP groups (p &lt; 0.001) on the dysmenorrhoea scale. The EABP group also had significantly higher scores for dyspareunia (p &lt; 0.001), even though more than 50% of sexually active participants in each pain group reported interrupting and/or avoiding sexual intercourse due to pain in the last 12 months. Scores for the QoL questionnaire (SF-36) reveal that CPP patients had significantly lower QoL across all SF-36 subscales (p &lt; 0.001). Significant effects were also observed between the pain groups for pain interference with their work (p &lt; 0.001) and daily lives (p &lt; 0.001), with the EABP suffering more compared to the EAP and PP groups (p &lt; 0.001).DiscussionOur results demonstrate the negative impact that chronic pain has on CPP patients' QoL and reveal an increased negative impact of pain on the comorbid EABP group. Furthermore, it demonstrates the importance of dyspareunia in women with CPP. Overall, our results demonstrate the need for further exploration of interventions targeting QoL more broadly and suggest that novel approaches to classifying women with CPP are needed.
Synthesis of end-user research to inform future multipurpose prevention technologies in sub-Saharan Africa: a scoping review
Authors: Bhushan Nivedita L. , Ridgeway Kathleen , Luecke Ellen H. , Palanee-Phillips Thesla , Montgomery Elizabeth T. , Minnis Alexandra M. 
Published: May 2023

IntroductionWomen in sub-Saharan Africa (SSA) experience disproportionately high rates of HIV infection and unintended pregnancy compared to their age-matched counterparts in other regions of the world. Multipurpose prevention technologies (MPTs) that offer protection against HIV and unintended pregnancy in a single product stand to address these dual sexual and reproductive health needs simultaneously. The aim of this scoping review is to identify factors that are important for optimizing the likelihood of MPT adoption by end users in SSA.MethodsStudy inclusion criteria included MPT research (HIV and pregnancy prevention dual indication) published or presented in English from 2000 to 2022 and conducted in SSA amongst end-users (women aged 15–44), male partners, health care providers, and community stakeholders. References were identified by searching peer reviewed literature, grey literature, conference presentations (2015–2022), grant databases, and outreach to MPT subject matter experts. Of 115 references identified, 37 references met inclusion criteria and were extracted for analysis. A narrative synthesis approach was used to summarize findings within and across MPT products.ResultsStudies were identified from six countries in SSA and a substantial proportion included a South African (n = 27) and/or Kenyan (n = 16) study site. Most studies utilized a qualitative study design (n = 22) and evaluated MPT acceptability and preferences by presenting hypothetical products through images or a list of product attributes (n = 21). The vaginal ring (n = 20), oral tablet (n = 20), and injection (n = 15) were examined most frequently. Across studies, there was high acceptability and demand for an HIV and pregnancy prevention MPT. End users valued choice in prevention product type as well as discreetness and long-acting options. Provider counseling and community sensitization were reported as essential for future introduction of novel MPT delivery forms.ConclusionRecognizing the heterogeneity of women's preferences and changing reproductive and sexual health needs over the life course, choice is important in the delivery of pregnancy and HIV prevention products as well as amongst MPT products with distinct product profiles. End user research with active MPTs, vs. hypothetical or placebo MPTs, is necessary to advance understanding of end-user preferences and acceptability of future products.
How to Catch an Atom: Tales on Time-Telling and Future Applications
Authors: Segev Noa , Wineland David 
Published: May 2023

This article is based on an interview between the two authors.Small particles, such as single photons, electrons, atoms or charged atoms (called ions), can experience a very different world from that which we usually perceive. While in our daily life, things seem to be reasonably predictable, continuous, and well-defined, in the “quantum” world of single or small numbers of particles, there are surprises and many unexpected “non-classical” behaviors. In addition to its complexity, the world of small particles opens up some very interesting possibilities for applications to practical problems. To take advantage of the amazing properties of small particles, scientists and other researchers have developed various techniques for holding and isolating photons, electrons, atoms, and ions and manipulating their behavior. In this article, we will try to give you a glance into the fascinating lives of small particles, tell you about techniques for working with them, and mention exciting new potential applications that take advantage of their unique behaviors.
A synthetic model simulator for intracranial aneurysm clipping: validation of the UpSurgeOn AneurysmBox
Authors: Ahmed Razna , Muirhead William , Williams Simon C. , Bagchi Biswajoy , Datta Priyankan , Gupta Priya , Salvadores Fernandez Carmen , Funnell Jonathan P. , Hanrahan John G. , Davids Joseph D. , Grover Patrick , Tiwari Manish K. , Murphy Mary , Marcus Hani J. 
Published: May 2023

Background and objectivesIn recent decades, the rise of endovascular management of aneurysms has led to a significant decline in operative training for surgical aneurysm clipping. Simulation has the potential to bridge this gap and benchtop synthetic simulators aim to combine the best of both anatomical realism and haptic feedback. The aim of this study was to validate a synthetic benchtop simulator for aneurysm clipping (AneurysmBox, UpSurgeOn).MethodsExpert and novice surgeons from multiple neurosurgical centres were asked to clip a terminal internal carotid artery aneurysm using the AneurysmBox. Face and content validity were evaluated using Likert scales by asking experts to complete a post-task questionnaire. Construct validity was evaluated by comparing expert and novice performance using the modified Objective Structured Assessment of Technical Skills (mOSATS), developing a curriculum-derived assessment of Specific Technical Skills (STS), and measuring the forces exerted using a force-sensitive glove.ResultsTen experts and eighteen novices completed the task. Most experts agreed that the brain looked realistic (8/10), but far fewer agreed that the brain felt realistic (2/10). Half the expert participants (5/10) agreed that the aneurysm clip application task was realistic. When compared to novices, experts had a significantly higher median mOSATS (27 vs. 14.5; p &lt; 0.01) and STS score (18 vs. 9; p &lt; 0.01); the STS score was strongly correlated with the previously validated mOSATS score (p &lt; 0.01). Overall, there was a trend towards experts exerting a lower median force than novices, however, these differences were not statistically significant (3.8 N vs. 4.0 N; p = 0.77). Suggested improvements for the model included reduced stiffness and the addition of cerebrospinal fluid (CSF) and arachnoid mater.ConclusionAt present, the AneurysmBox has equivocal face and content validity, and future versions may benefit from materials that allow for improved haptic feedback. Nonetheless, it has good construct validity, suggesting it is a promising adjunct to training.
The porcine piRNA transcriptome response to Senecavirus a infection
Authors: Wang Chen , Chen Yanxi , Yang Xiwang , Du Yunsha , Xu Zhiwen , Zhou Yuancheng , Yang Xu , Wang Xuetao , Zhang Chuanming , Li Shuwei , Yang Yijun , Li Wenting , Liu Xiao 
Published: May 2023

IntroductionSenecavirus A (SVA) belongs to the genus Senecavirus in the family Picornaviridae. PIWI-interacting RNAs (piRNAs) are a class of small Ribonucleic Acids (RNAs) that have been found in mammalian cells in recent years. However, the expression profile of piRNAs in the host during SVA infection and their roles are poorly understood.MethodsHere, we found the significant differential expression of 173 piRNAs in SVA-infected porcine kidney (PK-15) cells using RNA-seq and 10 significant differentially expressed (DE) piRNAs were further verified by qRT-PCR.ResultsGO annotation analysis showed that metabolism, proliferation, and differentiation were significantly activated after SVA infection. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that significant DE piRNAs were mainly enriched in AMPK pathway, Rap1 pathway, circadian rhythm and VEGF pathway. It was suggested that piRNAs may regulated antiviral immunity, intracellular homeostasis, and tumor activities during SVA infection. In addition, we found that the expression levels of the major piRNA-generating genes BMAL1 and CRY1 were significantly downregulated after SVA infection.DiscussionThis suggests that SVA may affect circadian rhythm and promote apoptosis by inhibiting the major piRNA-generating genes BMAL1 and CRY1. The piRNA transcriptome in PK-15 cells has never been reported before, and this study will further the understanding of the piRNA regulatory mechanisms underlying SVA infections.
Riga-Fede disease: a review of the literature and a description of clinical cases
Authors: Fomenko I. V. , Maslak E. E. , Kasatkina A. L. , Bavlakova V. V. , Fursik D. I. 
Published: May 2023

Relevance.Riga-Fede disease (RFD) is a rare pathology that develops as a result of trauma to the mucous membrane of the tongue ventral surface with sharp edges of natal, neonatal or primary teeth erupting in time and manifests in the form of erosion or sublingual fibrous lesion with an ulcerated surface.Purpose. To analyze the literature and present our own RFD clinical cases.Material and methods.A search was performed of articles published in 2001-2023 on the research topic in the main scientific literature databases (PubMed, E-library, Google Scholar, etc.). We analyzed the data from 68 publications and presented three of our own clinical cases of RFD in children aged 5, 6 and 9 months.Results.Analysis of literature data revealed different approaches to the diagnosis and treatment of RFD in children. The diagnosis of RFD should rely on the clinical picture and exclude additional trauma to children by histological examination and lesion excision. Pronounced tooth mobility, ineffective infant feeding and the presence of neurological diseases in patients were the main indications for the extraction of teeth, which caused RFD development. In the absence of tooth mobility, non-surgical treatment methods should be preferable. In the presented clinical cases, erupted primary teeth caused BRF. In two cases, the treatment consisted of smoothing the sharp edges of the teeth and restoration with glass ionomer cement; in one case, a child with a neurological disease experienced extraction of lower central incisors. In all cases, recovery was within 3-4 weeks.Conclusion.Once clinically diagnosed with RFD, treatment method choice should consider tooth mobility and the child's overall health.
L’évolution sémantique de au-dessus
Authors: Van Grunderbeek Lieve 
Published: May 2023

Si à l’origine au-dessus ne s’employait qu ’au sens figuré, de nos jours les sens figurés semblent être passés à l ’arrière-plan : c ‘est le sens spatial que nous considérons intuitivement comme prototypique et apte à expliquer, par métaphorisation, les emplois figurés . Cette évolution du figuré au spatial semble contredire l'hypothèse localiste et complique la tâche de décéler le sens protypique de la préposition.
Partant de la description de la préposition au-dessus par Vandeloise, nous déterminerons les conditions d'emploi de au-dessus à l’heure actuelle. Une étude diachronique nous permettra de décrire les étapes morphologiques et sémantiques successives et révélera que le sens spatial était tout de même présent dès le début, bien que de façon latente. Dès lors nous pouvons nous mettre sur une même ligne avec Vandeloise en décrivant le sens prototypique en termes spatiaux.