bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of redundant communications to enhance safety against communication interruptions during robotic remote surgery
Authors: Morohashi Hajime , Hakamada Kenichi , Kanno Takahiro , Tadano Kotaro , Kawashima Kenji , Takahashi Yoshiya , Ebihara Yuma , Oki Eiji , Hirano Satoshi , Mori Masaki 
Published: July 2023

AbstractIt is important to ensure the redundancy of communication during remote surgery. The purpose of this study is to construct a communication system that does not affect the operation in the event of a communication failure during telesurgery. The hospitals were connected by two commercial lines, a main line and a backup line, with redundant encoder interfaces. The fiber optic network was constructed using both guaranteed and best-effort lines. The surgical robot used was from Riverfield Inc. During the observation, a random shutdown and restoration process of either line was conducted repeatedly. First, the effects of communication interruption were investigated. Next, we performed a surgical task using an artificial organ model. Finally, 12 experienced surgeons performed operations on actual pigs. Most of the surgeons did not feel the effects of the line interruption and restoration on still and moving images, in artificial organ tasks, and in pig surgery. During all 16 surgeries, a total of 175-line switches were performed, and 15 abnormalities were detected by the surgeons. However, there were no abnormalities that coincided with the line switching. It was possible to construct a system in which communication interruptions would not affect the surgery.
Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer
Authors: Inomata Minehiko , Matsumoto Masahiro , Takata Naoki , Hayashi Kana , Seto Zenta , Hirai Takahiro , Tokui Kotaro , Taka Chihiro , Okazawa Seisuke , Kambara Kenta , Imanishi Shingo , Miwa Toshiro , Hayashi Ryuji , Matsui Shoko , Tobe Kazuyuki 
Published: July 2023

AbstractImmune checkpoint inhibitors have significantly improved the prognosis in patients with non-small cell lung cancer, compared with cytotoxic agents. However, the prediction of treatment response is often difficult, even after assessing the tumor programmed death-ligand 1 expression. We conducted this observational study to analyze the association between the differentiation of peripheral CD4 + T cells and the efficacy of immune checkpoint inhibitor therapy. We enrolled patients who were diagnosed with non-small cell lung cancer and received immune checkpoint inhibitor therapy between 2020 and 2022. Blood samples were collected at the start of immune checkpoint inhibitor therapy, and the expressions of PD-1, CCR7, and CD45RA in peripheral CD4 + T cells were analyzed by flow cytometry. The association between the findings of flow cytometry and survival after the initiation of the immune checkpoint inhibitor therapy was evaluated. Forty patients with non-small cell lung cancer were enrolled. The Cox proportional hazards model showed that an increased proportion of CD45RA-CD4 + T cells was associated with a reduced risk of progression after adjustment for performance status, tumor programmed death-ligand 1 expression level, mutation status of the epidermal growth factor receptor gene, and combined therapy with cytotoxic agents. The present study showed that the proportion of peripheral CD45RA- CD4 + T cells was associated with progression-free survival after the initiation of immune checkpoint inhibitor therapy, independent of several clinical factors.
Specific and label-free endogenous signature of dystrophic muscle by Synchrotron deep ultraviolet radiation
Authors: Dubreil Laurence , Damane Noreddine , Fleurisson Romain , Charrier Marine , Pichon Julien , Leroux Isabelle , Schleder Cindy , Ledevin Mireille , Larcher Thibaut , Jamme Frédéric , Puentes John , Rouger Karl 
Published: July 2023

AbstractDystrophic muscle is characterized by necrosis/regeneration cycles, inflammation, and fibro-adipogenic development. Conventional histological stainings provide essential topographical data of this remodeling but may be limited to discriminate closely related pathophysiological contexts. They fail to mention microarchitecture changes linked to the nature and spatial distribution of tissue compartment components. We investigated whether label-free tissue autofluorescence revealed by Synchrotron deep ultraviolet (DUV) radiation could serve as an additional tool for monitoring dystrophic muscle remodeling. Using widefield microscopy with specific emission fluorescence filters and microspectroscopy defined by high spectral resolution, we analyzed samples from healthy dogs and two groups of dystrophic dogs: naïve (severely affected) and MuStem cell-transplanted (clinically stabilized) animals. Multivariate statistical analysis and machine learning approaches demonstrated that autofluorescence emitted at 420–480 nm by theBiceps femorismuscle effectively discriminates between healthy, dystrophic, and transplanted dog samples. Microspectroscopy showed that dystrophic dog muscle displays higher and lower autofluorescence due to collagen cross-linking and NADH respectively than that of healthy and transplanted dogs, defining biomarkers to evaluate the impact of cell transplantation. Our findings demonstrate that DUV radiation is a sensitive, label-free method to assess the histopathological status of dystrophic muscle using small amounts of tissue, with potential applications in regenerative medicine.
Automated segmentation of the mandibular canal and its anterior loop by deep learning
Authors: Oliveira-Santos Nicolly , Jacobs Reinhilde , Picoli Fernando Fortes , Lahoud Pierre , Niclaes Liselot , Groppo Francisco Carlos 
Published: July 2023

AbstractAccurate mandibular canal (MC) detection is crucial to avoid nerve injury during surgical procedures. Moreover, the anatomic complexity of the interforaminal region requires a precise delineation of anatomical variations such as the anterior loop (AL). Therefore, CBCT-based presurgical planning is recommended, even though anatomical variations and lack of MC cortication make canal delineation challenging. To overcome these limitations, artificial intelligence (AI) may aid presurgical MC delineation. In the present study, we aim to train and validate an AI-driven tool capable of performing accurate segmentation of the MC even in the presence of anatomical variation such as AL. Results achieved high accuracy metrics, with 0.997 of global accuracy for both MC with and without AL. The anterior and middle sections of the MC, where most surgical interventions are performed, presented the most accurate segmentation compared to the posterior section. The AI-driven tool provided accurate segmentation of the mandibular canal, even in the presence of anatomical variation such as an anterior loop. Thus, the presently validated dedicated AI tool may aid clinicians in automating the segmentation of neurovascular canals and their anatomical variations. It may significantly contribute to presurgical planning for dental implant placement, especially in the interforaminal region.
Mathematical inspection of heat transfer and unsteady viscous flow in a tunnel with trapezoidal shaped slender wall
Authors: Riaz Dar Muhammad Naveel , Hussain Azad , Hussain Faizan , Alrasheedi Nashmi H. , Hajlaoui Khalil , Ben Hamida Mohamed Bechir 
Published: July 2023

AbstractAn exploration is made to investigate numerically and theoretically the time dependent flow of blood along with heat transfer through abnormal artery having trapezoidal shaped plaque. The flow is taken to be Newtonian, laminar, unsteady and incompressible. A suitable geometrical model is constructed to simulate the trapezoidal stenosis affected artery. The governed 2-dimensional momentum and heat transfer equations are conventionalized by assuming mild trapezoidal stenosis. The renovate partial differential equations are further converted into ordinary differential equations by assist of transformations. The novelty of the work is to consider unsteady blood flow through trapezoidal shape stenosed artery. A technique of finite difference is used to discretize the updated dimensionless model numerically. Comprehensive graphical outcomes for a flow of blood are obtained. The effect of trapezoidal plaque on blood velocity, pressure and temperature are shown by surface graph inside the artery and also shown with the help of line graph.
IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling affects disease severity in acute pancreatitis
Authors: Thiel Franziska G. , Asgarbeik Saeedeh , Glaubitz Juliane , Wilden Anika , Lerch Markus M. , Weiss Frank Ulrich , Sendler Matthias 
Published: July 2023

AbstractAcute pancreatitis (AP), which is characterized by self-digestion of the pancreas by its own prematurely activated digestive proteases, is a major reason for hospitalization. The autodigestive process causes necrotic cell death of pancreatic acinar cells and the release of damage associated molecular pattern which activate macrophages and drive the secretion of pro-inflammatory cytokines. The MYD88/IRAK signaling pathway plays an important role for the induction of inflammatory responses. Interleukin-1 receptor associated kinase-3 (IRAK3) is a counter-regulator of this pathway. In this study, we investigated the role of MYD88/IRAK using Irak3−/− mice in two experimental animal models of mild and severe AP. IRAK3 is expressed in macrophages as well as pancreatic acinar cells where it restrains NFκB activation. Deletion of IRAK3 enhanced the migration of CCR2+ monocytes into the pancreas and triggered a pro-inflammatory type 1 immune response characterized by significantly increased serum levels of TNFα, IL-6, and IL-12p70. Unexpectedly, in a mild AP model this enhanced pro-inflammatory response resulted in decreased pancreatic damage, whereas in a severe AP model, induced by partial pancreatic duct ligation, the increased pro-inflammatory response drives a severe systemic inflammatory response syndrome (SIRS) and is associated with an increased local and systemic damage. Our results indicate that complex immune regulation mechanism control the course of AP, where moderate pro-inflammation not necessarily associates with increased disease severity but also drives tissue regenerative processes through a more effective clearance of necrotic acinar cells. Only when the pro-inflammation exceeds a certain systemic level, it fuels SIRS and increases disease severity.
The fourth vaccination with a non-SARS-CoV-2 variant adapted vaccine fails to increase the breadth of the humoral immune response
Authors: Hein Sascha , Sabino Catarina , Benz Nuka Ivalu , Görgülü Esra , Maier Thorsten Jürgen , Oberle Doris , Hildt Eberhard 
Published: July 2023

AbstractEscape mutations in the spike protein of SARS-CoV-2 are a major reason for Omicron breakthrough infections. After basal vaccination only very low titers of Omicron neutralizing antibodies are present. However, booster vaccinations induce higher titers against the Omicron variant. The neutralization of the Delta and Omicron variants by sera obtained 6 months after 3rd vaccination and 2 weeks or 6 months after 4th vaccination with a monovalent RNA vaccine (Spikevax) was analyzed. It was observed for the Omicron variant that 6 months after the fourth vaccination, the titer returns to the same very low neutralizing capacity as 6 months after the third vaccination. The Delta variant neutralizing capacity wanes with a comparable kinetic although the titers are higher as compared to the Omicron variant. This indicates that the fourth vaccination with a monovalent vaccine based on the ancestral isolate neither affects the kinetic of the waning nor the breadth of the humoral response.
Coherent optical two-photon resonance tomographic imaging in three dimensions
Authors: Mazelanik Mateusz , Leszczyński Adam , Szawełło Tomasz , Parniak Michał 
Published: July 2023

AbstractMagnetic resonance imaging is a three-dimensional imaging technique, where a gradient of the magnetic field is used to interrogate spin resonances with spatial resolution. The application of this technique to probe the coherence of atoms with good three-dimensional resolution is a challenging application. We propose and demonstrate an optical method to probe spin resonances via a two-photon Raman transition, reconstructing the 3D-structure of an atomic ensemble’s coherence, which is itself subject to external fields. Our method relies on a single time-and-space resolved heterodyne measurement, allowing the reconstruction of a complex 3D coherence profile. Owing to the optical interface, we reach a tomographic image resolution of 14 × 14 × 36 μm3. The technique allows to probe any transparent medium with a resonance structure and provides a robust diagnostic tool for atom-based quantum information protocols. As such, it is a viable technique for application to magnetometry, electrometry, and imaging of electromagnetic fields.
Hinweisgeber im Augenweiß
Authors: Biechele Hermann 
Published: July 2023

SummaryAugendiagnostische Zeichen im Augenweiß zeigen sich vor allem im Bereich von Limbus (Übergangsbereich vom Augenweiß zur Hornhaut), Sklera, Episklera, Konjunktiva und in den Augenwinkeln. Phänomene in diesen Bereichen geben vorwiegend Hinweise auf Stoffwechsel, Lymph-, Gefäß- und Immunsystem. Insbesondere ist auf Verfärbungen und Lidspaltenflecke
Reuse of Nasoseptal Flaps for Endoscopic Endonasal Skull Base Reconstruction
Authors: Bobeff Ernest J. , Mathios Dimitrios , Longo Davide , Estin Joshua , Joshua Shejoy , Tabaee Abtin , Kacker Ashutosh , Anand Vijay K. , Schwartz Theodore H. 
Published: July 2023

Structured Abstract
Introduction Pedicled nasoseptal flap (NSF) placement is a critical component of skull base reconstruction after endoscopic endonasal approaches (EEAs). The effectiveness of NSF reuse has not been thoroughly studied. Prior reports using flaps harvested at one center and reused at another may have technical variability bias.
Methods We identified patients who underwent both their initial and NSF-reused surgeries at Weill Cornell Medical College from 2004 to 2022 using a prospective database of all EEAs. Surgical pathology, intraoperative leak grade, use of cerebrospinal fluid (CSF) diversion and skull base coverage were examined. The primary outcome measure was occurrence of CSF leak.
Results Fourteen patients (six women, eight men) underwent 14 first time and 14 revision operations with median age of 36.6 years (interquartile range [IQR]: 23.9–61.3) at the time of the NSF reuse. The median interval between the first NSF use and reuse was 70.6 months (IQR: 16.6–87). Eight patients were operated on for pituitary adenoma. Nonadenomas included three craniopharyngiomas and one case each of epidermoid, ependymoma, and chordoma. There were 16 high-flow, 8 low-flow intraoperative leaks, and 4 with no leak. CSF diversion was used in 24 operations. There were three postoperative leaks, one after a first operation and two after NSF reuse. All postoperative CSF leaks, whether first or second operations, occurred in cases with both high-flow intraoperative CSF leak and incomplete NSF coverage (p = 0.006).
Conclusion NSF reuse is effective at preventing postoperative CSF leak. The primary predictors of leak are high-flow intraoperative leak and inadequate defect coverage with NSF, regardless of the operation number.
Coordinating and sharing gesture spaces in collaborative reasoning
Authors: Williams Robert F. 
Published: July 2023

Abstract
In collaborative reasoning about what causes the seasons, phases of the moon, and tides, participants (three to
four per group) introduce ideas by gesturing depictively in personal space. Other group members copy and vary these gestures,
imbuing their gesture spaces with similar conceptual properties. This leads at times to gestures being produced in shared space as
members elaborate and contest a developing group model. Gestures in the shared space mostly coincide with conversational turns;
more rarely, participants gesture collaboratively as they enact a joint conception. An emergent shared space is sustained by the
joint focus and actions of participants and may be repositioned, reoriented, or reshaped to meet changing representational demands
as the discourse develops. Shared space is used alongside personal spaces, and further research could shed light on how gesture
placement and other markers (such as eye gaze) contribute to the meaning or function of gestures in group activity.
Personal and interpersonal competence of to-be translators and interpreters during COVID-19 remote learning (students’
perspective)
Authors: Hodáková Soňa , Perez Emília 
Published: July 2023

Abstract
The main focus of the study lies on the challenges, procedures and consequences in personal and interpersonal
competence development in university translation and interpreting (T&I) students during the COVID-19 pandemic. It reflects the
significant change in learning conditions in Slovakia after shifting from campus-based to remote learning throughout the three
waves of the pandemic, considering the personal and interpersonal competence an integral part of the curricula. The attention of
the authors centres on the students’ perspective – their insight and evaluation of the applied training procedures in selected
personal (self-assessment, time management, compliance with instructions and deadlines) and interpersonal (teamwork, collaborative
tasks, communication with the client/assignor) skills. The year-on-year comparison of students’ responses shows improvement in
training and learning strategies in almost all observed aspects of personal and interpersonal competence development and
demonstrates students’ general adaptation to the changed learning environment. The findings of the research, however, raise
several concerns related to students’ well-being and potential risks of mental health issues which appear to result from the
overall crisis situation, social distancing, but also increased workload and work-life imbalance.
The first courses on localization in Slovakia
Authors: Kabát Marián 
Published: July 2023

Abstract
In 2020 the first two courses on localization were introduced in Slovakia. During their preparatory stages, it was
thought that they would be taught in person. Unfortunately, the COVID-19 pandemic in Slovakia had worsened by the end of the
summer of 2020; teaching over both semesters was moved online and the syllabi had to be promptly adjusted to the new situation.
Another change in the syllabi was required in the following academic year as teaching began in a hybrid format.
The presented paper is a case study, and it will deal with the adjustments made to the courses; it will briefly
introduce the first syllabi and then present the changes made after the switch to distance teaching and after the switch to hybrid
teaching. The various parts of the syllabi are accompanied by statements from students that were gathered in an anonymous survey
after each semester to see whether they were satisfied with the course and whether they understood the problems they had been
dealing with. The results of the paper will discuss the changes, their positive and negative impact on the overall syllabi of the
first two localization courses, and improvements and changes.
Work-family interface and job outcomes among professional translators and interpreters
Authors: Kitanovska-Kimovska Sonja 
Published: July 2023

Abstract
The purpose of this paper is to investigate the mutual relationship between work and family among translators and
how that affects their job satisfaction and performance. More specifically, the study centres around the notions of work-family
conflict (Greenhaus, and Beutell 1985) and work-family facilitation (Frone 2003) and analyses what effect they have on translators’ job satisfaction and
performance. The study also tests the influence of the changes imposed due to the COVID-19 pandemic and the parenting role.
Following Choi and Kim (2012), a survey was conducted among a group of professional
translators which contained questions on all variables under study: work-family conflict, family-work conflict, work-family
facilitation, family-work facilitation, job satisfaction and job performance. The results reveal the influence of the work-family
interface on job outcomes. The findings of the study have implications for professional translators and the clients they work
for.
Experimental study of CO2 and N2 adsorption on activated carbon
Authors: Jedli Hedi , Almoneef M M , Mbarek Mohamed , Jbara Abdessalem , Slimi Khalifa 
Published: July 2023

Abstract
The present study as designed to assess the CO2 and N2 adsorption isotherms on activated carbon (AC). The AC was characterized with SEM, XRD and N2 isotherm. The CO2 and the N2 adsorption experiments on the AC are performed at 298, 308 and 328 K and modelled by Langmuir model. The preferred selectivity (α
CO2/N2) was obtained with the use of the Langmuir properties and the Henry coefficient (K

H
) was found from the virial equation. The thermodynamic analysis of CO2 and N2 adsorption which include the entropy loss (ΔS), the Gibbs free energy change (ΔG) and the surface potential (Ω) was calculated. The results reveal that the order of CO2 uptake on AC is higher than that of N2. α(CO2/N2) decreased with the increase of the temperature. The KH values of CO2 on the AC are the most important, while the KH values for N2 are the least. The thermodynamic parameters which include Ω,

Q

st

,

ΔG and ΔS are impacted by the porous structure of the AC.The adsorption affinity and the adsorption spontaneity of CO2 is the highest, while N2 has the lowest adsorption spontaneity. Subsequently, CO2 exhibits a higher interaction with AC, in contrast to N2 which displays a slight interaction.the obtained results can be used to CO2 capture and to improve the efficiency of CO2 adsorption devices.
Impact of peritoneal dialysis strategy on technique and patient survival
Authors: Sanchez Jose Emilio , Ulloa Catalina , Bueno Carmen Merino , Astudillo Elena , Rodríguez-Suárez Carmen 
Published: July 2023

ABSTRACT

Background
The aim of this study was to evaluate the impact of peritoneal dialysis (PD) strategy on technique and patient survival.

Methods
This was a retrospective, single-center study conducted on consecutive patients with chronic kidney disease who underwent PD between January 2009 and December 2019. The study sample was stratified into four different groups according to PD technique [automated (APD) or manual (CAPD)] and icodextrin use (yes versus no). The primary endpoints were survival of both technique and patient.

Results
A total of 531 patients were included in the analysis. Mean ± standard deviation age was 60.6 ± 14.6 years, 68.4% (363) were men and 34.8% (185) had diabetes. The median technique survival time was 19 (15) months. A total of 185 (34.8%), 96 (18.1%), 99 (18.7%) and 151 (28.4%) patients were included in the CAPD/No-Icodextrin, CAPD/Icodextrin, APD/No-Icodextrin and APD/Icodextrin study groups, respectively. Throughout the study, 180 (33.9%) patients underwent renal transplant, 71 (13.4%) were changed to hemodialysis and 151 (28.4%) died. Age [hazard ratio (HR) 0.975, 95% confidence interval (CI) 0.960–0.990, P = .001] and incidence of early peritoneal infection (HR 2.440, 95% CI 1.453–4.098, P = .001) were associated with technique survival, while age (HR 1.029, 95% CI 1.013–1.045, P &lt; .001), Charlson Index (HR 1.192, 95% CI 1.097–1.295, P &lt; 0.001), use of icodextrin (HR 0.421, 95% CI 0.247–0.710, P &lt; .001) and APD/Icodextrin (HR 0.499, 95% CI 0.322–0.803, P = .005) were associated with patient survival.

Conclusions
Icodextrin use and APD/Icodextrin had a positive impact on patient survival, while older age and higher Charlson Index had a negative one. Age and incidence of early peritoneal infection significantly impacted on technique survival.