bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PERUBAHAN LAJU TEMPERATUR TUNGKU FORGING PORTABLE DENGAN PEMBESARAN 5 CM BUKAAN LUBANG PEMBAKARAN
Authors: Widodo Ongki Prima , Armila Armila , Kurniawan Arief Rudi 
Published: June 2023

A metallurgical furnace is needed in the metal forming process, a portable forging furnace is an installation tool specifically designed for metal heating, for the plastic deformation process in the forging process in the material technology laboratory. This heating furnace was made by Feriadi Sidik with an initial opening of 50 mm diameter, only capable of reaching a temperature of 3000C with a hole position of 15:85 cm. the inability of this furnace to reach temperatures greater than 10000C which causes the practicum process to be hampered, therefore modifications were made by widening the combustion opening from 50 mm to 100 mm. Enlargement of these openings results in a change in compressor pressure which results in a change in the air flow rate so that the temperature propagates up. The increase in temperature is measured from changes in the compressor speed and the resulting temperature at the initial pressure (P= 17.2km/h, T= 309.20C), and the final pressure (P=23.2km/h, T= 14320C), with testing time for from 30 seconds to 300 seconds. From the modification results, it is proven that by increasing the opening of the combustion hole, it can produce a change in the temperature rate. This modified furnace can be used to heat low carbon steel and high carbon steel for the forging process. Keywords: Furnace, Modification, Forging, Temperature, openings
ANALISA STABILITAS TRANSIEN PADA JARINGAN DISTRIBUSI RADIAL IEEE 33 BUS TERHUBUNG DENGAN ENERGI TERBARUKAN (PHOTOVOLTAIC)
Authors: Wahyudi Rio , Yulisman Yulisman , Yamashika Herris 
Published: June 2023

Energi listrik merupakan energi sekunder yang banyak digunakan diberbagai sektor, baik digunakan untuk keperluan rumah tangga maupun keperluan industri. Untuk memenuhi kebutuhan listrik di era ekonomi yang tumbuh sangat pesat ini membutuhkan banyak energi listrik. Oleh karena itu kualitas energi listrik perlu ditingkatkan. Letak pembangkit yang jauh dari beban juga menyebabkan tingginya nilai drop tegangan pada beberapa bus, selain itu juga menyebabkan rugi-rugi daya sistem yang cukup besar.Metode yang bisa digunakan pada penelitian ini dengan memasang teknologi fotovoltaik sebagai distributed generation (DG) atau pembangkit terdistribusi yang memiliki kapasitas daya yang lebih kecil dari pembangkit utama.Dengan adanya DG yang ditempatkan pada ujung beban yang mempunyai kapasitas kecil dapat membantu mengatasi masalah suplai energi listrik. Penggunaan atau penambahan DG dalam sistem disdribusi tentunya memiliki dampak terhadap sistem. Dilihat dari respon frekuensi, tegangan, dan aliran daya penambahan DG dalam sistem memiliki berbagai macam dampak. Dampak yang ada bergantung pada peletakan DG pada sistem, jumlah beban yang ada, rating DG yang digunakan, dan jenis pembangkit yang digunakan. Tugas akhir ini berfokus pada analisa kestabilan transien pada sistem pada jaringan distribusi IEEE 33 Bus terhubung dengan enegi terbaruan (Photovoltaic). Kata Kunci : Stabilitas Transien, Distributed Generation, Aliran daya
ANALISIS PERENCANAAN PEKERJAAN DRAINASE TIPE U-DITCH BETON BERTULANG JALAN A. YANI KOTA PAYAKUMBUH
Authors: Rahman Andika , Eka Priana Surya , Herista Febrimen 
Published: June 2023

Banjir dan genangan air telah menjadi masalah yang cukup lama terjadi pada kawasan Jalan A. Yani Kota Pyakumbuh. Masalah tersebut disebabkan karena daerah tersebut cenderung datar, sehingga aliran air hujan relatif lambat dan kecepatan aliran dapat mendekati titik nol, serta kualitas saluran yang tidak memadai untuk menampung debit yang datang dari saluran primer. Tujuan dari penelitian ini untuk merencanakan sistem drainase pada jalan A. Yani Kota Payakumbuh. Metode pengolahan data menggunakan metode Log Normal untuk menentukan hujan rencana dan perhitungan secara manual dengan metode rasional untuk menghitung debit hujan, dan rumus Manning untuk debit saluran. Setelah dilakukan perhitungan maka didapat debit maksimal dari dimensi saluran drainase eksisting tahunan dalam 2 tahun = 1.13 m3/dtk , 5 tahun = 1.56 m3/dtk dan 10 tahun = 2.23 m3/dtk. Maka direncanakan dimensi saluran drainase untuk saluran drainase sekunder jalan A.Yani Kota Payakumbuh dengan tipe saluran U-Ditch yaitu dengan saluran kanan U-Ditch 1.2 m x 1.4 m dan saluran kiri U-Ditch 1,25 m x1,45 m. Dengan kemampuan debit maksimal rencana saluran kanan sebesar 2.58 m3/dtk dan debit maksimal rencana saluran kiri sebesar 2.872 m3/dtk. Kata Kunci : Drainase , Metode Log Normal, U-Ditch, Debit Hujan(Q).
Design and computational optimization of compliance-matching aortic grafts
Authors: Rovas Georgios , Bikia Vasiliki , Stergiopulos Nikolaos 
Published: June 2023

Introduction: Synthetic vascular grafts have been widely used in clinical practice for aortic replacement surgery. Despite their high rates of surgical success, they remain significantly less compliant than the native aorta, resulting in a phenomenon called compliance mismatch. This incompatibility of elastic properties may cause serious post-operative complications, including hypertension and myocardial hypertrophy.Methods: To mitigate the risk for these complications, we designed a multi-layer compliance-matching stent-graft, that we optimized computationally using finite element analysis, and subsequently evaluated in vitro.Results: We found that our compliance-matching grafts attained the distensibility of healthy human aortas, including those of young adults, thereby significantly exceeding the distensibility of gold-standard grafts. The compliant grafts maintained their properties in a wide range of conditions that are expected after the implantation. Furthermore, the computational model predicted the graft radius with enough accuracy to allow computational optimization to be performed effectively.Conclusion: Compliance-matching grafts may offer a valuable improvement over existing prostheses and they could potentially mitigate the risk for post-operative complications attributed to excessive graft stiffness.
Microbiology and prognostic prediction model of bloodstream infection in patients with hematological malignancies
Authors: Wang Jinjin , Wang Mengyao , Zhao Ailin , Zhou Hui , Mu Mingchun , Liu Xueting , Niu Ting 
Published: June 2023

BackgroundIn recent years, with the continuous development of treatments for hematological malignancies (HMs), the remission and survival rates of patients with HMs have been significantly improved. However, because of severe immunosuppression and long-term recurrent neutropenia during treatment, the incidence and mortality of bloodstream infection (BSI) were all high in patients with HMs. Therefore, we analyzed pathogens’ distribution and drug-resistance patterns and developed a nomogram for predicting 30-day mortality in patients with BSIs among HMs.MethodsIn this retrospective study, 362 patients with positive blood cultures in HMs were included from June 2015 to June 2020 at West China Hospital of Sichuan University. They were randomly divided into the training cohort (n = 253) and the validation cohort (n = 109) by 7:3. A nomogram for predicting 30-day mortality after BSIs in patients with HMs was established based on the results of univariate and multivariate logistic regression. C-index, calibration plots, and decision curve analysis were used to evaluate the nomogram.ResultsAmong 362 patients with BSIs in HMs, the most common HM was acute myeloid leukemia (48.1%), and the most common pathogen of BSI was gram-negative bacteria (70.4%). The final nomogram included the septic shock, relapsed/refractory HM, albumin &lt;30g/l, platelets &lt;30×109/l before BSI, and inappropriate empiric antibiotic treatment. In the training and validation cohorts, the C-indexes (0.870 and 0.825) and the calibration plots indicated that the nomogram had a good performance. The decision curves in both cohorts showed that the nomogram model for predicting 30-day mortality after BSI was more beneficial than all patients with BSIs or none with BSIs.ConclusionIn our study, gram-negative bacterial BSIs were predominant in patients with HMs. We developed and validated a nomogram with good predictive ability to help clinicians evaluate the prognosis of patients.
The imPAct of Trimetazidine on MicrOcirculation after Stenting for stable coronary artery disease (PATMOS study)
Authors: Ilic Ivan , Timcic Stefan , Milosevic Maja , Boskovic Srdjan , Odanovic Natalija , Furtula Matija , Dobric Milan , Aleksandric Srdjan , Otasevic Petar 
Published: June 2023

BackgroundMyocardial ischemia is caused by epicardial coronary artery stenosis or atherosclerotic disease affecting microcirculation. Trimetazidine (TMZ), promotes glucose oxidation which optimizes cellular energy processes in ischemic conditions. Small studies demonstrated protective effects of TMZ in terms of reducing myocardial injury after percutaneous coronary intervention (PCI), its effect on microcirculation using contemporary investigative methods has not been studied. The aim of the study was to examine effects of trimetazidine, given before elective PCI, on microcirculation using invasively measured index of microcirculatory resistance (IMR).MethodsThis was prospective, single blinded, randomized study performed in a single university hospital. It included consecutive patients with an indication for PCI of a single, de novo, native coronary artery lesion. Patients were randomly assigned to receive either TMZ plus standard therapy (TMZ group) or just standard therapy. Coronary physiology indices fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) were measured before and after PCI using coronary pressure wire.ResultsWe randomized 71 patients with similar clinical characteristics and risk profile, previous medications and coronary angiograms. Patientshad similar values of Pd/Pa, FFR and CFR prior to PCI procedure. After PCI, FFR values were higher in TMZ group, while IMR values were lower in this group respectively (FFR TMZ + 0.89 ± 0.05 vs. TMZ – 0.85 ± 0.06, p = 0.007; CFR TMZ + 2.1 ± 0.8 vs. TMZ- 2.3 ± 1.3, p = 0.469; IMR TMZ + 18 ± 9 vs. TMZ- 24 ± 12, p = 0.028). In two-way repeated measures ANOVA PCI was associated with change in FFR values (TMZ p = 0.050; PCI p &lt; 0.001; p for interaction 0.577) and TMZ with change in IMR values (TMZ p = 0.034, PCI p = 0.129, p for interaction 0.344).ConclusionAdding trimetazidine on top of medical treatment prior to elective PCI reduces microvascular dysfunction by lowering postprocedural IMR values when compared to standard therapy alone.
Economics in primary schools: an empirical experiment from Hungary
Authors: Nagy Judit 
Published: June 2023

The paper highlights the importance and relevance of introducing economic studies to primary schools. The research aimed to investigate the appropriate age, environment, type, and composition of presentation for introducing combined economic knowledge. The 190 students participating in the research were students from three primary schools in Hungary from 10 classes. Given the fact that in the case of all of the significant results, a sufficient effect size could be measured, and furthermore, the relevant test value was very high, it is unambiguously proven that the size of the sample (n= 190) that was used for the examination was sufficient. The results suggest that teaching economic and financial knowledge through accounting and making lectures interactive using special tools of positive education is critical to stimulating children’s interest. Eighty percent of the students in the study liked the combined and interactive lecture. Another goal was to investigate whether those that liked the presentation would perform better on the related knowledge test, which proved to be the case. In the two target groups, students in grade 6 outperformed students in grade 3 on the test. An investigation of gender performance is also included in the research. Findings suggest that the respective education may appropriately be developed based on the close relationship between mathematics and accounting. The lectures can be adapted according to any national or international accounting standards (IFRS, etc.) and can be taught in an online classroom as well. The lectures aim to develop children’s independent problem-solving skills so they can adapt the information to their own lives and financial situations. The paper fills a gap in the research by describing a successful attempt to complex economic literacy.JEL Classification codeA29, M21, M41
Continuous vs. discontinuous purification of isolated human islets: functional and morphological comparison
Authors: Buemi Antoine , Mouard Nizar I. , Darius Tom , Devresse Arnaud , Kanaan Nada , Gianello Pierre , Mourad Michel 
Published: June 2023

BackgroundThe COBE 2991 cell processor, commonly used for pancreatic islet isolation, is no longer distributed in Europe, leading to a search for alternative purification procedures with equivalent efficacy. The aim of this study was to evaluate the efficacy of an alternative method based on the discontinuous purification of islets.MethodsThe conventional isolation procedure using a standard continuous islet purification with COBE 2991 of n = 4 human pancreas was compared to n = 8 procedures using a discontinuous purification with a “bottle” method from donors of similar characteristics. Islet equivalents, purity, and dynamic glucose-stimulated insulin secretion were evaluated.ResultsA similar islet yield was obtained using continuous vs. discontinuous purification methods (76,292.5 ± 40,550.44 vs. 79,625 ± 41,484.46 islet equivalents, p = 0.89). Islets from both groups had similar purity (78.75% ± 19.73% vs. 55% ± 18.16%, p = 0.08) and functionality both in terms of stimulation index (3.31 ± 0.83 vs. 5.58 ± 3.38, p = 0.22) and insulin secretion (1.26 ± 0.83 vs. 1.53 ± 1.40 mean AUC, p = 0.73). Moreover, the size of the islets was significantly larger in the discontinuous vs. continuous purification group (19.2% ± 10.3% vs. 45.4% ± 18.8% of islets less than 100 µm, p = 0.0097 and 23.7% ± 5.3% vs. 15.6% ± 5.8% of 200–250 µm islet size, p = 0.03).ConclusionCompared to the conventional purification procedure, discontinuous purification with a bottle method shows similar results with regard to isolation yield and islet secretory function. Furthermore, this alternative technique allows for obtaining larger islets.
Atrial natriuretic peptide and leptin interactions in healthy men
Authors: Daniels Martin A. , Fischer-Posovszky Pamela , Boschmann Michael , Jumpertz-von Schwartzenberg Reiner , Müller Timo D. , Sandforth Leontine , Frank-Podlech Sabine , Hülskämper Sonja , Peter Andreas , Wabitsch Martin , Jordan Jens , Birkenfeld Andreas L. 
Published: June 2023

IntroductionAtrial natriuretic peptide (ANP), a hormone secreted from the heart, controls cardiovascular and renal functions including arterial blood pressure and natriuresis. ANP also exerts metabolic effects in adipose tissue, liver and skeletal muscle, and interacts with the secretion of adipokines. We tested the hypothesis that ANP lowers concentrations of the anorexigenic adipokine leptin in healthy humans in vivo.MethodsHuman ANP or matching placebo was infused intravenously (iv) into healthy men in a controlled clinical trial.ResultsWithin 135 minutes of iv ANP infusion, we observed an acute decrease in plasma leptin levels compared to controls. Free fatty acids markedly increased with ANP infusion in vivo, indicating activated lipolysis. In human SGBS adipocytes, ANP suppressed leptin release.DiscussionThe study shows that the cardiac hormone ANP reduces the levels of the anorexigenic adipokine leptin in healthy humans, providing further support for ANP as a cardiomyokine in a heart - adipose tissue axis. (registered in the German Clinical Trials Register and the WHO International Clinical Trials Registry Platform was granted under DRKS00024559)
Two-Sample Mendelian Randomization detects bidirectional causality between gut microbiota and celiac disease in individuals with high genetic risk
Authors: González-García Bárbara P. , Marí Sergi , Cilleros-Portet Ariadna , Hernangomez-Laderas Alba , Fernandez-Jimenez Nora , García-Santisteban Iraia , Bilbao Jose Ramon 
Published: June 2023

BackgroundCeliac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.5/DQ2.2 heterozygous. Both the HLA-DQ2-positive high genetic risk individuals and those that have developed the disease have altered intestinal microbiota, but it remains unclear whether these alterations are a cause or a consequence of CeD.ObjectiveTo investigate a potential bidirectional causality between gut microbiota (GM) and CeD in HLA-DQ2 high genetic risk individuals.Materials and MethodsWe performed a bidirectional Two-Sample Mendelian Randomization (2SMR) test using summary statistics from the largest publicly available Genome-Wide Association Study (GWAS) of GM and the summary statistics of the Immunochip CeD study of those individuals with the HLA-DQ2 high-risk haplotype. To test whether changes in GM composition were causally linked to CeD, GM data were used as exposure and CeD data as outcome; to test for reverse causation, the exposure and outcome datasets were inverted.ResultsWe identified several bacteria from Ruminococcaceae and Lachnospiraceae families of the Firmicutes phylum as potentially causal in both directions. In addition, our results suggest that changes in the abundance of Veillonellaceae family might be causal in the development of CeD, while alterations in Pasteurellaceae family might be a consequence of the disease itself.ConclusionOur results suggest that the relationship between GM and HLA-DQ2 high risk individuals is highly complex and bidirectional.
Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress
Authors: Martín-Adrados Beatriz , Wculek Stefanie K. , Fernández-Bravo Sergio , Torres-Ruiz Raúl , Valle-Noguera Ana , Gomez-Sánchez Maria José , Hernández-Walias José Carlos , Ferreira Frederico Moraes , Corraliza Ana María , Sancho David , Esteban Vanesa , Rodriguez-Perales Sandra , Cruz-Adalia Aránzazu , Nakaya Helder I. , Salas Azucena , Bernardo David , Campos-Martín Yolanda , Martínez-Zamorano Elena , Muñoz-López Diego , Gómez del Moral Manuel , Cubero Francisco Javier , Blumberg Richard S. , Martínez-Naves Eduardo 
Published: June 2023

IntroductionThe Unfolded Protein Response, a mechanism triggered by the cell in response to Endoplasmic reticulum stress, is linked to inflammatory responses. Our aim was to identify novel Unfolded Protein Response-mechanisms that might be involved in triggering or perpetuating the inflammatory response carried out by the Intestinal Epithelial Cells in the context of Inflammatory Bowel Disease.MethodsWe analyzed the transcriptional profile of human Intestinal Epithelial Cell lines treated with an Endoplasmic Reticulum stress inducer (thapsigargin) and/or proinflammatory stimuli. Several genes were further analyzed in colonic biopsies from Ulcerative Colitis patients and healthy controls. Lastly, we generated Caco-2 cells lacking HMGCS2 by CRISPR Cas-9 and analyzed the functional implications of its absence in Intestinal Epithelial Cells.ResultsExposure to a TLR ligand after thapsigargin treatment resulted in a powerful synergistic modulation of gene expression, which led us to identify new genes and pathways that could be involved in inflammatory responses linked to the Unfolded Protein Response. Key differentially expressed genes in the array also exhibited transcriptional alterations in colonic biopsies from active Ulcerative Colitis patients, including NKG2D ligands and the enzyme HMGCS2. Moreover, functional studies showed altered metabolic responses and epithelial barrier integrity in HMGCS2 deficient cell lines.ConclusionWe have identified new genes and pathways that are regulated by the Unfolded Protein Response in the context of Inflammatory Bowel Disease including HMGCS2, a gene involved in the metabolism of Short Chain Fatty Acids that may have an important role in intestinal inflammation linked to Endoplasmic Reticulum stress and the resolution of the epithelial damage.
Neutrophil-to-lymphocyte ratio predicts 30-, 90-, and 180-day readmissions of patients with hepatic encephalopathy
Authors: Zhang Lin , Zhang Wei , Wang Jian , Jin Qian , Ma Danli , Huang Rui 
Published: June 2023

IntroductionHepatic encephalopathy (HE) is a significant complication of cirrhosis, known to be associated with hospital readmission. However, few new serological indicators associated with readmission in HE patients have been identified and reported. The objective of our study was to identify simple and effective predictors reated to readmission in HE patients.Materials and methodsWe conducted a retrospective study at a single center on adult patients admitted with HE from January 2018 to December 2022. The primary endpoint was the first liver-related readmission within 30, 90, and 180 days, and we collected electronic medical records from our hospital for sociodemographic, clinical, and hospitalization characteristics. We utilized logistic regression analysis and multiple linear regression analysis to determine the predictors that were associated with the readmission rate and the length of the first hospitalization.ResultsA total of 424 patients were included in the study, among whom 24 (5.7%), 63 (14.8%), and 92 (21.7%) were readmitted within 30, 90, and 180 days, respectively. Logistic regression analysis showed that insurance status, alcoholic liver disease (ALD), ascites, the model for end-stage liver disease (MELD) score, and neutrophil-to-lymphocyte ratio (NLR) were significantly associated with 30-, 90-, and 180-day readmissions. Age and hepatocellular carcinoma (HCC) were predictors of 90- and 180-day readmissions. ALD was identified as a unique predictor of readmission in men, while hypertension was a predictor of 180-day readmission in women. Variceal bleeding, chronic kidney disease, and MELD score were associated with the length of the first hospitalization.ConclusionsNLR at discharge was identified as a significant predictor of 30-, 90- and 180-day readmissions in patients with HE. Our findings suggest that incorporating NLR into routine clinical assessments could improve the evaluation of the prognosis of liver cirrhosis.
The platelet transcriptome and proteome in Alzheimer’s disease and aging: an exploratory cross-sectional study
Authors: de Sousa Diana M. Bessa , Poupardin Rodolphe , Villeda Saul A. , Schroer Adam B. , Fröhlich Thomas , Frey Vanessa , Staffen Wolfgang , Mrowetz Heike , Altendorfer Barbara , Unger Michael S. , Iglseder Bernhard , Paulweber Bernhard , Trinka Eugen , Cadamuro Janne , Drerup Martin , Schallmoser Katharina , Aigner Ludwig , Kniewallner Kathrin M. 
Published: June 2023

Introduction: Alzheimer’s disease (AD) and aging are associated with platelet hyperactivity. However, the mechanisms underlying abnormal platelet function in AD and aging are yet poorly understood.Methods: To explore the molecular profile of AD and aged platelets, we investigated platelet activation (i.e., CD62P expression), proteome and transcriptome in AD patients, non-demented elderly, and young individuals as controls.Results: AD, aged and young individuals showed similar levels of platelet activation based on CD62P expression. However, AD and aged individuals had a proteomic signature suggestive of increased platelet activation compared with young controls. Transcriptomic profiling suggested the dysregulation of proteolytic machinery involved in regulating platelet function, particularly the ubiquitin-proteasome system in AD and autophagy in aging. The functional implication of these transcriptomic alterations remains unclear and requires further investigation.Discussion: Our data strengthen the evidence of enhanced platelet activation in aging and provide a first glimpse of the platelet transcriptomic changes occurring in AD.