bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genre grammatical et désignation des référents humains dans l’oral non planifié
Authors: Branca-Rosoff Sonia , Dister Anne 
Published: September 2023

Cet article s’intéresse à l’emploi des genres grammaticaux pour les noms référant à des humains dans un oral non planifié. Notre analyse repose sur l’observation de sept heures de parole à partir du Corpus de français parlé parisien (CFPP2000, Branca et al. , 2012) et du Corpus de français parlé à Bruxelles (CFPB, Dister et Labeau, 2017), soit 1616 noms. Sur la base de 5 catégories que nous avons distinguées, nous montrons la répartition des emplois au masculin et au féminin, et l’importance des catégories renvoyant potentiellement autant à un homme qu’à une femme : épicènes (n=353), collectifs renvoyant à des groupes mixtes (n=506), noms à genre fixe comme personne , mais qui peuvent renvoyer indifféremment à un homme ou à une femme (n=51). Nous examinons ensuite le fonctionnement du masculin, en distinguant les emplois spécifiques et les emplois neutralisants, pour les noms à alternance du morphème flexionnel (n=300), et pour les noms épicènes masculins (n=82). Pour ces catégories, au pluriel, les emplois neutralisés représentent les trois quarts des usages. La catégorie sexuée est donc fréquemment neutralisée, en particulier grâce aux épicènes et à l’emploi du masculin pluriel. L’observation qualitative des corpus montre cependant que les informations sur le sexe des référents peuvent être réintroduites au fil du discours, quand le besoin s’en fait sentir. Les locuteurs peuvent sans « trouble » passer d’un épicène masculin, conçu comme englobant les deux sexes, à un féminin pour évoquer une personne spécifique.
Un pas vers soi, un pas vers l’autre
Authors: Carrette Gaëlle , Belala Nabila 
Published: September 2023

Psychomotricité et Danse Thérapie sont deux formations complémentaires l’une de l’autre. Nous (psychomotricienne et infirmière danse thérapeute) travaillons toutes les deux dans un CATTP de secteur de psychiatrie adulte. Mettre en commun nos compétences pour créer un atelier a été une évidence. Pour être dans un contact adapté à l’autre, il faut d’abord être en contact avec son propre corps, ceci a été notre idée fondatrice. Le fil conducteur de cet atelier est donc la relation, la relation à son corps et la relation à l’autre. Plus simplement dit : un pas vers soi, un pas vers l’autre, induisant une mise en mouvement du corps. Ainsi, notre atelier se nomme « Corps en mouvements ».
Mémoires de la première guerre punique à l’époque impériale et au Moyen Âge
Authors: Courroux Pierre , Engerbeaud Mathieu 
Published: September 2023

Cet article propose d’étudier la mémoire de la première guerre punique sur le temps long, du début du Principat jusqu’à la veille de la Renaissance. Cette approche diachronique permet d’observer comment, sur une durée de quinze siècles, les épisodes majeurs de cette guerre ont été interprétés, modifiés, réappropriés au gré de l’évolution des sociétés et des centres d’intérêt des élites cultivées. Assurément, le premier conflit qui opposa les Romains aux Carthaginois retenait l’intérêt des Anciens, car il constituait la première guerre de Rome contre une grande puissance méditerranéenne. Au cours de l’Empire et du Moyen Âge, les Anciens ont plusieurs fois revisité les moments les plus marquants de cette guerre, dont les lettrés antiques et médiévaux se sont emparés pour construire des exempla.
A comparison of the range of motion and dynamic stability of the ankle joint of athletes with an ankle sprain as compared to healthy controls: A cross-sectional study
Authors: Alomar Ahmed I. , Nuhmani Shibili , Ahsan Mohammad , Muaidi Qassim I. 
Published: September 2023

ABSTRACT

Background:
Ankle sprains are the most common lower-leg musculoskeletal injuries, frequently occurring among athletes and other physical activity individuals. The objective of this study was to compare the ankle range of motion and dynamic stability of healthy and injured athletes for their dominant and nondominant legs.

Methods:
A cross-sectional study design was selected to investigate this study with 32 male soccer players with average age: 22.6 ± 3.3 years, weight: 69.6 ± 5.7 kg, height: 176.8 ± 5.32 cm, with a history of a lateral ankle sprain on the dominant leg for the past 2 years. Ankle range of motion was determined using dorsiflexion and plantar flexion by a goniometer. The dynamic stability was determined using the SWAY medical system. An independent t-test was used to study the differences between healthy and injured groups and between dominant and nondominant legs for dynamic stability, dorsiflexion, and plantar flexion range.

Results:
There were higher significant differences for dynamic stability in healthy participants than in injured participants for their dominant (P = 0.001) and nondominant (P = 0.001) legs. There were significant differences in dynamic stability in the dominant and nondominant leg (healthy [P = 0.033] and injured [P = 0.000] participants). The dominant leg shows higher dynamic stability in healthy group, whereas nondominant leg shows higher dynamic stability in the injured group.

Conclusion:
The study found significant differences between the injured and sound legs. The injured dominant and nondominant leg revealed a striking disparity in the ankle range of motion. Therefore, the study demonstrated that ankle sprain causes due to less stability of the ankle joint, which limits ankle movements.
The Association between Perceived Job Stress and Satisfaction, Empathy and Spiritual Beliefs on Burnout and Emotional Distress in Nurses: A Cross-sectional Study
Authors: Debnath Sudipta , Sathiyaseelan Manoranjitham , Tharyan Prathap , Mahasampath Gowri 
Published: September 2023

Background:
Nursing is a noble profession, which comes with a lot of responsibilities, workload, and demands made by the various stakeholders of health-care industry. Maintaining an empathic nurse–patient relationship is at its core, irrespective of the types of nursing care being rendered. This study aims to assess the association between perceived job stress and satisfaction, empathy, and spiritual beliefs on burnout and emotional distress, in nurses.

Methodology:
A cross-sectional research design was undertaken to meet the study objectives. Data were collected from a total of 257 consenting nurses, using the modified Consultants Job Stress and Satisfaction questionnaire, Maslach Burnout Inventory, Jefferson Scale of Physician Empathy-Health Provider Version, and General Health Questionnaire-12.

Results:
High empathy was related to lower depersonalization (DP) and higher personal accomplishment. Nurses who agreed on to their work beliefs being influenced by spiritual beliefs also had more commonly reported high job stress. More than a third (34.24%) of the nurses were emotionally distressed with a significant score in General Health Questionnaire-12 (GHQ-12). The GHQ-12 score significantly varied with high emotional exhaustion (EE), high DP, and job stress.

Conclusion:
Empathy and spiritual belief act as modifying factors for job stress and job satisfaction, respectively. A significant proportion of the nurses were found to have emotional distress which was significantly related to EE, DP, and job stress. A training module including strategies to build empathetic skills, stress management, and ways to promote psychological well-being, should be embedded in the curriculum of new graduate nurses.
Management and outcome of EGFR mutant lung cancer with SARS-CoV-2 infection
Authors: Kolluri Spoorthy , Panda Soumya Surath , Panda Adyakinkar , Singh Santosh Kumar 
Published: September 2023

ABSTRACT
The world and India, in particular, have been grappling with the coronavirus disease (COVID-19) pandemic for more than a year now. The simultaneous presence of active COVID-19 infection with lung cancer poses both a diagnostic and therapeutic dilemma, because of similar clinical, radiological features along with increased susceptibility to ICU admissions and death. We present the case of a metastatic EGFR mutant lung cancer patient who was started on Gefitinib during active COVID-19 infection. He had made a complete recovery from COVID-19 infection while achieving a partial response to therapy in terms of primary lung cancer. The case highlights the importance of active involvement of a medical oncologist in the care of all cancer patients with COVID-19 infection instead of the traditional holding of all therapy for cancer until COVID-19 recovery as suggested by the majority of guidelines.
p16 expression in urothelial carcinoma: Experience from a tertiary care center in coastal South India
Authors: Sachdeva Sanjana , Suresh Pooja K. , Basavaiah Sridevi H. , Sahu Kausalya K. , Sreeram Saraswathy , Kini Hema , Kini Jyoti R. , Pinto Amanda C. 
Published: September 2023

ABSTRACT

Background:
Urothelial carcinomas (UC) account for 6 and 2% of all cancers in men and women, respectively. Human papillomavirus (HPV) is one of the causative agents in cancers of the uterine cervix and head and neck. The role of HPV is also being studied in cancers of the urinary bladder, penis, and prostate. As p16-INK4a is a surrogate marker for high-risk HPVE7 oncoprotein, this study aims to highlight the utility of p16 immunohistochemistry (IHC) in the evaluation of HPV-associated UC.

Materials and Methods:
A retrospective study was conducted on UC of the bladder received in the Pathology department between January 2013 and December 2018. Bladder biopsies from non-neoplastic lesions served as controls. IHC was done for the detection of the p16 antigen. The p16 staining was recorded as positive, when there was strong staining in >50% of tumor nuclei. The p16 positive and negative tumors were compared based on age, gender, tumor size, grade, and muscle invasion. P value <0.05 was considered statistically significant.

Results:
The expression of p16 was analyzed in 72 UC and compared with 20 non-neoplastic cases, of which 26.4% of the cases showed p16 expression. The p16 expression was absent in the non-neoplastic lesions. While the majority (87.5%) of the low-grade tumors were negative for p16 expression, 43.8% high-grade tumors were positive. Similarly, a larger proportion of invasive carcinomas (38.8%) expressed p16 as compared to non-invasive carcinomas (13.8%). Thus, p16 expression showed a significant association with grade and stage in these malignancies (P < 0.05).

Conclusion:
The p16 expression was associated with high-grade and muscle-invasive UC. The p16 was absent in all non-neoplastic and precursor lesions. Thus, it can provide essential information not only about HPV association but also on the prognostic implications for the patients.
Spontaneous vanishing of hepatocellular carcinoma: A case report of an extremely rare incident
Authors: El-Kassas Mohamed , El Sheemy Reem Y. , Sweedy Ahmad T. , Abdelmaksoud Ahmed Hosni 
Published: September 2023

ABSTRACT
One of the very uncommon clinical conditions is the spontaneous remission of tumors, with scarce reports around the world in various types of tumors. Spontaneous remission of hepatocellular carcinoma (HCC) is extremely rare, but it is well documented with a still unclear underlying mechanism. In this case report, we present one of those exceptional incidents of HCC regression with a trial to tackle possible explanations. Our case, which has a history of successfully treated hepatitis C virus, presented with a large infiltrative right lobar mass invading the main portal vein, with markedly elevated alpha fetoprotein (AFP). According to the applied diagnostic and treatment guidelines, the patient was scheduled for conservative management. Although he did not receive any specific treatments for his condition, the mass regressed in size with recanalization of the portal vein and normalization of AFP after 6 months of follow-up and keep the same for the following 3 years. The mechanisms by which spontaneous regression of HCC can occur are still unknown and should be furtherly investigated better to understand the behavior of such aggressive neoplastic disease.
Dietary risk factors in gastrointestinal cancers: A case–control study in North India
Authors: Nadeem Shoket , Dinesh Kumar , Tasneef Zargar , Bhavna Sahni , Rahul Sharma , Kiran Bala 
Published: September 2023

ABSTRACT

Background:
One-third of all cancer deaths are preventable by alterations in diet.

Methods:
A case control study was conducted in a Regional Cancer Center in North India to evaluate the relationship of diet with selected gastrointestinal cancers. A total of 171 cases, 151 hospital controls, and 167 healthy controls were interviewed using food frequency questionnaire. Data was analyzed using odds ratio with 95% confidence interval and Chi-square test.

Results:
Two to three times increased risk of GI cancers was observed with hot and salted tea. Alcohol [OR 2.30 (1.32-4)] and smoking [OR (2.77 (1.77-4.33)] emerged as risk factors in healthy controls among whom freshly prepared food had significant protective effect [OR 0.57 (0.37-0.88)]. Sweet tea showed protective effect in hospital and healthy controls (OR 0.33 and 0.26, respectively). NSAIDS was associated with significantly higher risk of GI cancers. Consumption of dietary fibers decreased risk, which was significant for wheat and pulses but insignificant for rice. Vegetables and fruits showed significant protective effect ranging from 20 to 80% while intake of non-vegetarian foods showed significantly higher odds among controls (OR 2.37–13.4). Odds of GI cancer cases having consumed chutneys and pickles were significantly higher in comparison to healthy controls while consumption of dairy products showed protection. Low and medium intake of mixed spices inclusive of curcumin showed protection (OR 0.13 and 0.39, respectively) while intake of red chillies was associated with 2–30 times significantly higher odds.

Conclusions:
We have been able to generate baseline evidence of association between diet and selected GI cancers to encourage prevention and further research.
The utility of serum amylase as a prognostic marker in multiple myeloma
Authors: Chetana Panthula Sree Vamsee , Krishnan Sajitha , Jose Wesley M. 
Published: September 2023

ABSTRACT

Background:
Ectopic production of amylase by tumor cells is known since 1951. Elevated amylase in multiple myeloma (MM) was first described in 1988. It has been postulated that translocation of chromosome 1, where amylase gene is situated, is responsible for ectopic production from the malignant plasma cells. Anecdotal reports have shown hyperamylasemia in MM to be associated with extensive bone disease, rapid progression, and shorter survival. Serum amylase estimation is a ubiquitous test. This prospective study was conducted to ascertain the degree of elevated amylase, its clinical utility, and implications in MM patients.

Materials and Methods:
In an 18-month period, all consenting patients with newly diagnosed or relapsed MM were tested for serum amylase levels. The study excluded patients with elevated lipase, abnormal creatinine clearance, and evidence of intestinal obstruction or perforation. Patients with amylase value >100 U/L were designated to have “elevated amylase level” for the purpose of this study.

Results:
We enrolled 58 patients with MM, of which 29.3% (n = 17) were found to have elevated serum amylase levels. The median age of patients with elevated amylase was 65 years. The male-to-female ratio was 1.9:1. There was no statistical association between age, gender, type of heavy chain class, light chain, or high-risk cytogenetics. Among patients with the International Staging System (ISS), Stages I, II, and III, 20.8% (n = 5), 31.3% (n = 5), and 41.2% (n = 7) were noted to have elevated amylase levels. A statistically significant association was noted between the presence of extramedullary disease (EMD) and elevated amylase level (P = 0.028). Higher mortality (29.4% versus 17%) and shorter mean survival of (30.2 ± 3.3 months versus 51.7 + 4.9 months) were recorded in patients with elevated amylase levels in comparison to those with normal levels.

Conclusions:
Elevated serum amylase level in MM is indicative of advanced ISS stage, the presence of EMD, higher risk of mortality, and shorter survival. Serum amylase can be used as a cost-effective tool in myeloma management.
Association of serum adiponectin levels and ADIPOQ SNP rs2241766 with breast cancer risk in Indian women
Authors: Govindarajan Sumitra , Saxena Alpana , Mahajan Bhawna , Mahto Mala 
Published: September 2023

ABSTRACT

Context:
Adiponectin, an adipokine, and its gene polymorphisms have been associated with breast cancer risk in various populations.

Subjects and Methods:
In this study, we evaluated the association of the circulating levels of adiponectin and adiponectin gene polymorphism SNP rs2241766 with breast cancer and its clinicopathological characteristics in Indian women. A case-control study was carried out with 60 Ductal Infiltrating Breast Carcinoma patients and 60 age-matched healthy controls. Serum adiponectin levels were measured by ELISA. SNP genotyping was done by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism.

Statistical Analysis:
Serum adiponectin levels were compared using the Mann Whitney U test. The frequency of genotypes was compared using the Chi-square test. The odds ratio was calculated using logistic regression.

Results:
Lower serum adiponectin level was associated with increased risk of breast cancer in postmenopausal women (OR – 7.69; 95% CI – 2.16–27.43, P = 0.002) but not in the reproductive age group women. There was no association between adiponectin levels with the TNM stage of the tumor, histopathological grade, erbB2, and ER/PR status. The SNP rs2241766 polymorphism was not associated with breast cancer risk but the mutant genotypes TG/GG was found to be significantly associated with the lower histopathological grade of the tumor (X2 (2, N = 60) = 8.62, P = 0.01).

Conclusion:
Our results suggest that low serum adiponectin levels are associated with an increased risk of breast cancer in postmenopausal women. The TG/GG genotypes of SNP rs2241766 polymorphism were associated with a lower histological grade of the tumor.
Real-world evidence of sorafenib for the treatment of hepatocellular carcinoma: A single-center study
Authors: Lopez-Lopez Aida , Gayoso-Rey Mónica , Garcia-Beloso Nerea , Romero-Ventosa Yaiza , Robles-Torres David , Martinez-Reglero Cristina , Piñeiro-Corrales Guadalupe 
Published: September 2023

ABSTRACT

Context:
Hepatocellular carcinoma is the third leading cause of cancer death. Currently, sorafenib is the treatment of choice in advanced hepatocarcinoma.

Aims:
Assessing the effectiveness and toxicity of sorafenib in real-word clinical practice in patients with hepatocarcinoma.

Settings and Design:
Single-centered observational retrospective study.

Methods and Material:
We included patients with hepatocarcinoma who began treatment with sorafenib between 2008 and 2018. We evaluated overall survival, time to progression, and response using RECIST (Response Evaluation Criteria in Solid Tumors) criteria. Toxicity was assessed according to the Common Terminology Criteria for Adverse Events version 5. 2020.

Statistical Analysis Used:
Kaplan–Meier curves and the log-rank test were used to determine the survival time and estimate factors associated with these events. Data were analyzed with SPSS 19.0 software.

Results:
We included 36 patients (88.9% male) with an average age of 64 ± 3.4 years. The tumor stage was advanced (C) in 21 patients (61.8%). We obtained a median overall survival of 8.5 months (IQR 3.14–18.9) and a time to progression of 4.5 months (IQR 2.4–8.8). The main degree of response was progression in 19 patients (36.1%), followed by stable disease in 13 (52.8%). The most commonly reported adverse reactions were: constitutional (83.3%), gastrointestinal (55%) and dermatological symptoms (50.0%). The development of grades 3 or 4 toxicity was not associated with increased overall survival (P = 0.719).

Conclusions:
The findings of the survival analysis obtained in real practice are similar to those obtained in pivotal clinical trials. Adverse reactions were different from those expected.
Treating low- and intermediate-risk acute promyelocytic leukemia with and without chemotherapy: A comparison in a tertiary care center
Authors: Saxena Mohit , Madabhavi Irappa V. , Patel Apurva , Panchal Harsha , Anand Asha 
Published: September 2023

ABSTRACT

Background:
Acute promyelocytic leukemia (APL) comprises approximately 10% of acute myeloid leukemia (AML) cases.

Material and Methods:
Both options of treatment (ATRA–ATO and ATRA–chemotherapy) were discussed with patients with low- and intermediate-risk APL, pros and cons explained in details, and treatment regimen selected after getting informed written consent.

Results:
Total 71 patients were included in the study; among these patients, 3 were negative for both FISH for t (15,17) and RT-PCR for promyelocytic leukemia retinoic acid receptor alpha, and 36 patients with APL had white blood cell count at diagnosis >10 × 109/l. Total 30 patients with newly diagnosed as low- and intermediate-risk-APL fulfilled all inclusion criteria, treated and followed for a minimum period of 2 years up to June, 2016. Fifteen patients liked to be treated with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), while rest of the 15 patients preferred treatment with ATRA and chemotherapy.

Conclusion:
Combination of ATRA and ATO is equally effective, less toxic, and more feasible in comparison to ATRA and chemotherapy for patients with low- and intermediate-risk APL and is a viable option for this subset of patients, especially in countries with limited resources.
Comparative study of concurrent conventional chemoradiotherapy versus hypofractionated chemoradiotherapy in newly diagnosed glioblastoma multiforme postoperative patients
Authors: Khatri Naresh Kumar , Kumar H. S. , Sharma Neeti , Jakhar Shankar Lal , Dhaka Saroj 
Published: September 2023

ABSTRACT

Purpose:
To assess the treatment response and toxicity profile among two groups of newly diagnosed glioblastoma multiforme (GBM) postoperative patients receiving conventional radiotherapy (RT) versus hypofractionated RT with concurrent temozolomide (TMZ) in both.

Materials and Methods:
A total of 50 patients randomly allotted into two arms (25 in each). Dose received 60 Gy (2 Gy/#) in conventional fractionation RT versus 50 Gy (2.5 Gy/#) in hypofractionated RT with concurrent TMZ 75 mg/m2 orally daily in both arms, respectively. Follow-up was done at 1, 3, 6, and 12 months after completion of treatment to evaluate toxicities, treatment response, and progression-free survival (PFS).

Results:
All patients were well tolerated with treatment; no major adverse effects were monitored in two arms. There was no statistical significant difference in treatment response, which was found 64% versus 60% in arm A and arm B, respectively, at 3 months of follow-up (P = 0.768). Toxicity profiles were also noted similar in both arms. The 6-month PFS was 84% and 80% in arm A and arm B, respectively (P = 0.71) and 12-month PFS was 60% and 52% in arm A and arm B, respectively (P = 0.69).

Conclusion:
Among the patients followed, this study showed that hypofractionated RT regimen was not inferior to conventional RT regimen.