bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcomes of zirconia dental implants: a systematic review and future directions
Authors: Arefnia Behrouz , Fakheran Omid , Jakse Norbert , Payer Michael 
Published: January 2025

Abstract

Purpose
Zirconia dental implants show excellent biocompatibility and tissue integration, low affinity for plaque, and favorable biomechanical properties. However, these objective measures do not adequately replicate the patient’s perception. This systematic review evaluated the evidence on patient-reported outcome (PROs) in zirconia dental implant treatment.

Methods
A systematic literature review was conducted following the PRISMA guidelines, utilizing six electronic databases, and supplemented by a manual search of relevant journals and websites to ensure a thorough and comprehensive screening process. The identified studies were subjected to preidentified inclusion criteria. Only controlled clinical trials published in English were considered without limitations on the year of publication. Data on the study characteristics (follow-up, survival rate (%), implant system, number of implants, and type of treatment), PROMs, level of evidence, and Methodological Index for Nonrandomized Studies (MINORS) Bias Score were extracted.

Results
The initial database and hand search yielded 596 articles; 189 were included in the title and abstract screening after excluding the duplicates. Eighteen articles were selected based on the inclusion criteria, among which six were excluded because they did not match the research question. Thus, the final selection comprised 12 articles. Most PROMs (aesthetics, speaking, comfort, chewing ability, and general satisfaction) at prosthetic delivery revealed significantly improved average scores than those at pretreatment.

Conclusions
Despite the respective limitations of the articles included in this systematic review, patients revealed high satisfaction levels with regard to zirconia dental implants. A high level of heterogeneity was observed among the instruments used for measuring the patient-reported outcomes in patients with zirconia implants, thus highlighting the need to develop specific PROMs in the future.
Breaking the silos: integrated approaches to foster sustainable development and climate action
Authors: Lah Oliver 
Published: January 2025

Abstract
A number of critical disconnects across sectors, actors continue to affect implementation action on sustainable development and climate action. Even when technical solutions, political commitments, and funding streams are avaiable, implementation often remains siloed and fragmented. This debate piece does not present definitive solutions or conclusive evidence; rather, it aims to foster critical reflection on how co-design, participatory approaches, Living Labs, and epistemically connected actor coalitions may help break down institutional and conceptual barriers. It proposes the SCALE framework [Shared epistemic foundations, Cross-sectoral integration, Adaptive co-design, Local enabling environments, and Evaluation & expansion) as way of operationalising the Safe Systems for Sustainable Development concept presented in Lah 2024, exploring how knowledge integration, iterative experimentation, and locally grounded solutuions can help creating implementation partnerships that last. This approach highlights questions concerning resource intensity, longevity, and scalability that must be addressed. By facilitating co-design, testing and validation of concrete solutions at the local level, the approach presented in this paper invites policymakers, researchers, practitioners, and civil society actors to engage in a more nuanced and constructive debate on whether, how, and under what conditions sustainable development solutions are considered to be viable and hence can endure even in politically volatile environments.
Effective community engagement in one health research in Sub-Saharan Africa: a systematic review
Authors: Sangong Sidney , Saah Farrukh Ishaque , Bain Luchuo Engelbert 
Published: January 2025

Abstract

Background
The one health (OH) approach, linking human, animal, and environmental health, relies on effective community engagement (CE), education, stewardship, and effective regional and global partnerships. For real impact, communities should be at the centre of research agenda setting and program implementation. This review aimed at synthesizing empirical evidence on how communities are involved in one health research. Specifically, the review aimed at documenting the extent of community involvement in one health research, as well as to identify the barriers and facilitators to effective community engagement in one health research in sub Saharan Africa.

Methods
The study was a systematic review conducted using the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Empirical peer-reviewed research articles on community engagement in one health research published from January 2000 to September 2023 in English or French were retrieved from seven databases: MEDLINE, EMBASE, CINAHL, Cochrane Library, WHO Afro Library, the National Institute for Health Research, and African Journals Online databases. The extracted data from the included studies were analysed using a thematic synthesis approach.

Results
The final review and synthesis included eight studies. The extent of CE in the one health research approach is quite limited. Two main best practices of CE in OH research were: 1) Awareness raising on OH research through social mobilization, rural outreach sensitization, and wide community assembly and 2) Building local capacity through community-based OH Training and Leadership workshops. The barriers to effective CE included: inadequate community research literacy levels, contextual disparities in CE, inadequate dissemination of research findings, language barriers and ineffective and uncoordinated stakeholder involvement.

Conclusion
The review underscores the importance of effective CE in one health research. The best practices for CE in one health research are raising awareness and co-creation which should guide future initiatives. There are cultural, geographical, linguistic, and educational constraints that pose barriers to CE, requiring a more integrated and community-centric approach to one health research in SSA. An effective CE in one health research through this approach will ultimately lead to more effective responses and control of zoonotic disease outbreaks.
Effects of antidepressants on body weight in patients treated in a naturalistic setting in Oman
Authors: AL-Jahwari Latifa , Qutishat Mohammed , Almaqbali Mandhar , Al Risi Khalid , AlBreiki Mohammed , Albalushi Mohammed , Al-Huseini Salim 
Published: January 2025

Abstract

Background
The rising use of antidepressants is critical for managing mental health disorders, but weight gain is a concerning side effect, particularly with certain classes like TCAs and SSRIs. This study aims to investigate weight changes in Omani patients prescribed paroxetine, fluoxetine, mirtazapine, or venlafaxine.

Method
A cross-sectional study conducted from January to June 2023 at Sultan Qaboos University Hospital recruited adults with mental disorders on these medications. Weight measurements were taken at baseline and follow-up, with clinically significant weight gain defined as a ≥ 7% increase.

Results
A total of 135 participants were analyzed, showing a mean weight gain of 5.54 kg, with 60.7% experiencing significant weight gain. Mirtazapine and paroxetine exhibited the highest average weight increases (7.51 kg and 8.05 kg, respectively) compared to fluoxetine (0.69 kg) and venlafaxine (4.32 kg). No significant demographic factors influenced weight changes (p = 0.213).

Conclusion
The study highlights significant weight gain among Omani patients on antidepressants, particularly mirtazapine and paroxetine. This underscores the importance of monitoring weight in clinical practice and necessitates further investigations into individualized treatment strategies to manage both mental health and weight-related concerns.
Disordered eating behaviors among a sample of final-year medical students at Cairo University and its relationship with alexithymia and social cognition
Authors: Elsherif Esraa S. , Al-Rakhawy Mona Y. , Fathy Heba , Adel Ashraf , Khalaf Ola O. 
Published: January 2025

Abstract

Background
This study aims to estimate the risk of eating disorders and their related factors among final-year medical students. Additionally, the present study is assessing the disordered eating behaviors relationship with alexithymia and social cognition.

Methods
An approved descriptive cross-sectional study was carried out at Cairo University’s Faculty of Medicine from August 2021 to December 2022. The participants were categorized into two distinct groups: Group A (students at risk for eating disorders) and Group B (students not at risk for eating disorders). All participants were evaluated using the Eating Attitude Test-26 (EAT-26), the Eating Disorder Examination Questionnaire (EDE-Q), the Toronto Alexithymia Scale (TAS-20), the Emotion Identification Test from the Ekman Program, and Reading the Mind in the Eyes Test-revised version (RMET).

Results
A total of 370 final-year students, both male and female, participated in the study. Group A included 136 students (37%), while Group B consisted of 234 students (63%). Female students exhibited a greater risk for developing an eating disorder (p =  < 0.001). Students classified as at risk for eating disorders displayed significantly elevated alexithymia scores and diminished social cognition scores when compared to their counterparts without risk (p =  < 0.001).

Conclusion
Medical students are more susceptible to eating-related problems. Deficits in alexithymia and social cognition potentiate the risk of eating disorders.
Noninvasive in vivo assessment of placental insufficiency using pCASL: a prospective case–control study
Authors: Awad Ghada , Reda Alaa Mohamed , Younis Rasha Lotfy , Hassan Manal Mostafa , Ali Rania Essam Eldin Mohamed 
Published: January 2025

Abstract

Background
Arterial spin labeling is a noninvasive imaging modality that does not use contrast for evaluation of placental perfusion in the placental pathological conditions. Our study enrolled 30 pregnant females with different risk factors for developing IUGR and other 30 females with the same age group having normal pregnancy. The two groups were evaluated by free breathing arterial spin labeling magnetic resonance imaging. Image findings of pseudo-continuous arterial spin labeling were compared to color duplex Doppler ultrasound of umbilical and middle cerebral arteries.

Aim
The aim of the present study was to evaluate the role of pseudo-continuous arterial spin labeling in measurement of placental perfusion with quantitative analysis of regional placental blood flow.

Methods
This prospective case–control study enrolled 30 pregnant females who had different causes of placental insufficiency, and another healthy group of matched ages, all were evaluated by 2D and color duplex Doppler ultrasound, conventional non-contrast magnetic resonance imaging and MRI perfusion using arterial spin labeling technique. The study was carried out from October 2021 to October 2023.

Results
Significant relation was found between placental perfusion values and umbilical and middle cerebral artery resistive indices as indicator for placental insufficiency with sensitivity and specificity 77.8%, 80%, respectively, for umbilical artery resistive index and 90%, 83.3%, respectively, for middle cerebral artery resistive index. While the diagnostic value of ASL perfusion was as follows, it had sensitivity = 90%, specificity = 83.3%, PPV = 84.4%, NPV = 89.3% and accuracy = 86.7%.

Conclusions
ASL-MRI is an excellent noninvasive in vivo MRI technique for evaluation of placental perfusion and quantitative analysis of regional placental blood flow in cases of placental insufficiency. This study supported the value of the new noninvasive MRI techniques in the elaboration of placental pathology.
Sonographic assessment of post-intubation laryngeal obstruction as predictor of weaning outcome
Authors: Anwar Mohamed Taher , Esmat Amro Ahmed , Elfeqy Mohamed Elsaid Ali Hassan 
Published: January 2025

Abstract

Background
Post-extubation stridor indicates the presence of laryngeal edema. The documented occurrence of post-extubation airway blockage ranges from 4 to 37%.

Aim
To evaluate the effectiveness of sonar assessment of laryngeal air column width difference to predict post-extubation upper airway obstruction and its relation to cuff leak volume.

Patients and methods
This was an observational, descriptive cross-sectional study, conducted on 48 mechanically ventilated patients fulfilling weaning criteria at the ICU of Chest Department, Faculty of Medicine, Zagazig University, from July 2022 to March 2023.

Results
A statistically insignificant variance was observed among COPD, ILD, overlap (OSA-COPD), pneumonia, aspiration pneumonia, and PE regarding laryngeal air column width difference (LACWD), while a statistically significant variance was observed among COPD, ILD, overlap (OSA-COPD), pneumonia, aspiration pneumonia, and PE regarding CLV; there was no correlation among cuff leak volume and LACWD, and there were 40 patients (83.3%) who had no post-intubation upper air way obstruction and 8 patients (16.7%) had post-intubation upper airway obstruction: 4 of them (8.3%) had success weaning, and 4 (8.3%) had failed weaning; and at cutoff value 140 ml, cuff leak volume had sensitivity of 100% and specificity of 97.5% with significance for prediction of stridor, and at cutoff value 1.15 mm, LACWD had sensitivity of 87.5% and specificity of 67.5% with significance for prediction of stridor.

Conclusion
Cuff leak volume and ultrasound-guided LACWD effectively predict post-extubation upper airway obstruction, suggesting their integration into institutional extubation protocols.
Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials
Authors: Liu Jia , Farrow Max , Seymour Lesley , Desai Jayesh , Loong Herbert H. , Ivy Percy , Koyoma Takafumi , Cook Natalie , Blagden Sarah , Garralda Elena , Massard Christophe , Tolcher Anthony W. , Adashek Jacob J. , Zhang Li , Zhao Shen , Shen Lin , Kurzrock Razelle , El-Deiry Wafik S. , Subbiah Vivek , Joshua Anthony M. 
Published: January 2025

PURPOSE
Over the past 15 years, the landscape of early phase clinical trials (EPCTs) has undergone a remarkable expansion in both quantity and intricacy. The proliferation of sites, trials, sponsors, and contract research organizations has surged exponentially, marking a significant shift in research conduct. However, EPCT operations suffer from numerous inefficiencies, such as cumbersome start-up processes, which are particularly critical when drug safety and the recommended phase II dose need to be established in a timely manner. Networks and consortia may overcome some of these challenges of enrolling suitable patients and streamlining start-up, particularly when distance and disease trajectory come into play.

DESIGN
In this article, we provide an overview of EPCT consortia in adult oncology across different continents assembled through systematic review of the literature and snowball sampling methodology. We illustrate their scope, structure, funding, and achievements.

RESULTS
Fifteen EPCT consortia were identified including two in the United States, three in Europe, five in Asia-Pacific, two intercontinental consortia, and three within private oncology networks. These consortia vary in their scope, funding, and structure from government-funded models such as the National Cancer Institute Experimental Therapeutics Clinical Trials Networks through charitably funded and private research organizations. EPCT consortia play a role in collaborative research, molecular tumor boards to provide patient-centric biomarker-matched treatments, and streamlining trial conduct to improve timelines and cost efficiency.

CONCLUSION
The growth in EPCT activity and complexity has resulted in expansion in the number of EPCT consortia globally. By actively engaging with regulatory bodies and pharmaceutical and contract research organization industries, consortia have an opportunity to address the evolving challenges faced in this field and to accelerate the translation of scientific discoveries into clinical practice.
Planned Surgical Trajectory Affects Clinical Motor Outcome in Deep Brain Stimulation Targeted at Subthalamic Nucleus for Parkinson's Disease
Authors: Wang Laura S. , Younce John R. , Milchenko Mikhail , Ushe Mwiza , Alfradique-Dunham Isabel , Tabbal Samer D. , Dowling Joshua L. , Perlmutter Joel S. , Norris Scott A. 
Published: January 2025

BACKGROUND AND OBJECTIVES:
Surgical planning is critical to achieve optimal outcome in deep brain stimulation (DBS). The relationship between clinical outcomes and DBS electrode position relative to subthalamic nucleus (STN) is well investigated, but the role of surgical trajectory remains unclear. We sought to determine whether preoperatively planned DBS lead trajectory relates to adequate motor outcome in STN-DBS for Parkinson's disease (PD).

METHODS:
In 49 participants who underwent bilateral STN-DBS for PD using a Leksell® frame, we coregistered the frame and participant MRI images to obtain participant-specific anatomical planes. We evaluated relationships between clinical data and planned trajectories relative to their midsagittal and axial planes. We computed percent change in Unified PD Rating Scale subsection 3 (Unified Parkinson's Disease Rating Scale, part III) scores before and after DBS, and performed binary logistic regression to determine whether planned trajectories affect adequate (>30% Unified Parkinson's Disease Rating Scale, part III improvement) motor outcome.

RESULTS:
Preoperatively planned left lead trajectory relative to midsagittal plane predicted likelihood of adequate right body motor outcomes (odds ratio = 0.69, P = .024), even when controlling for ventricular width through Evans index. This effect reflects that increasingly lateral angle of approach reduced odds of adequate motor outcome. Right lead trajectory lacked a similar trend.

CONCLUSION:
Left DBS lead trajectory predicts adequate right-body motor outcome after bilateral STN-DBS. Greater planned trajectory angle relative to midsagittal plane reduces motor outcomes, independent of patients' ventricular width. These data may guide patient selection, inform risk/benefit discussions, optimize surgical planning, or support evidence-based evaluation of the methodologies used to select the approach trajectory, with careful consideration of the angle of approach relative to target.
Development and Validation of a GULP-Based Predictive Model for Dehydration in Elderly Patients with Post-Stroke Dysphagia
Authors: Liang Yan , Dai Xin , Wei Bing , Jia Haiyan , Zhang Jinxiu , Qiu Zi , Zhang Qian 
Published: January 2025

Aims/Background The background for establishing and verifying a dehydration prediction model for elderly patients with post-stroke dysphagia (PSD) based on General Utility for Latent Process (GULP) is as follows: For elderly patients with PSD, GULP technology is utilized to build a dehydration prediction model. This aims to improve the accuracy of dehydration risk assessment and provide clinical intervention, thereby offering a scientific basis and enhancing patient prognosis. This research highlights the innovative application of GULP technology in constructing complex medical prediction models and addresses the special health needs of elderly stroke patients. Based on GULP criteria, the study aims to establish and validate a dehydration prediction model for elderly patients with dysphagia following a stroke. Methods Two hundred patients with post-stroke dysphagia treated at Beijing Rehabilitation Hospital Affiliated with Capital Medical University, from January 2020 to December 2023, were selected retrospectively. The patients were randomly matched at a ratio of 1:4 to establish a verification group (n = 40) and a modelling group (n = 160). Based on the occurrence of dehydration, the modelling group patients were divided into two groups: the dehydration group (n = 55) and the non-dehydration group (n = 105). Univariate and multivariate logistic regression analyses were used to identify the influencing factors of dehydration in elderly patients with dysphagia after a stroke, and to establish a predictive model based on GULP. The predictive value of the model was evaluated using receiver operating characteristic (ROC) curve analysis. Results The results of univariate and multivariate logistic regression analyses showed significant differences in age, lesion location, muscle strength grade, homocysteine (Hcy), and swallowing function score (p < 0.05). When these influencing factors were included in the model, the slope of the calibration curve in both the training set and the validation set was close to 1, indicating that the predicted dehydration risk was consistent with the actual risk. ROC analysis results revealed that in the training set, the model predicted dehydration in elderly post-stroke patients with dysphagia with an area under the curve (AUC) of 0.934, a standard error of 0.034, and a 95% confidence interval (CI) of 0.916 to 0.981. The optimal cutoff value was 0.78, yielding a sensitivity of 88.84% and a specificity of 90.00%. In the validation set, the AUC was 0.867 with a standard error of 0.025 and a 95% CI of 0.694 to 0.934. The optimal cutoff value here was 0.66, with a sensitivity of 80.16% and a specificity of 85.94%. Conclusion This study successfully established and validated a GULP-based dehydration prediction model for elderly patients with dysphagia following a stroke, demonstrating high application value.
Predictive Value of Ocular Fundus Hemorrhage for Severe Coronary Artery Disease Assessed via SYNTAX Score
Authors: Ge Xing , Liu Xiaoli , Sun Tienan , Gao Xinxiao , Han Hongya , Zhou Yujie 
Published: January 2025

Aims/Background The relationship between retinal fundus hemorrhage and the severity of coronary artery lesions remains unclear. This study aimed to explore the incidence of fundus hemorrhage in patients at high risk of coronary heart disease (CHD) and to examine its correlation with the SYNTAX score, a tool used to assess the complexity of coronary artery disease. Methods This retrospective study consecutively enrolled patients undergoing coronary angiography (CAG) at Beijing Anzhen Hospital Hospital from June 2019 to January 2020. Bilateral non-mydriatic fundus photography was performed to detect fundus hemorrhages. The SYNTAX score was calculated to quantify the severity of coronary artery lesions, and patients were divided into two groups: a high SYNTAX score (hSS) group (≥23 points) and a low SYNTAX score (lSS) group (≤22 points). Baseline demographic and clinical data were collected, along with relevant laboratory tests. Results A total of 878 patients were included in the study, with 177 in the hSS group and 701 in the lSS group. Fundus hemorrhage was observed in 91 patients (incidence: 10.36%, 95% confidence interval (CI): 8.35%–12.38%). The incidence of fundus hemorrhage was significantly higher in the hSS group compared to the lSS group (21.47% [38/177] vs. 7.56% [53/701], p < 0.001). Multivariate logistic regression analysis identified fundus hemorrhage, body mass index (BMI), and low-density lipoprotein cholesterol (LDL-C) as independent predictors of high SYNTAX scores. Conclusion Fundus hemorrhage is significantly associated with a higher SYNTAX score and may serve as a potential predictor of severe coronary artery lesions in clinical practice.