bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as apoptosis agent of breast cancer MCF-7 Cells
Authors: Arsianti Ade , Nur Azizah Norma , Erlina Linda 
Published: August 2023

Background In 2020, breast cancer has become the most common cancer in the world and in Indonesia. Searching for anticancer drugs using computational methods is considered more effective and selective than other methods. Gallic acid and its derivatives (esters and amides) are compounds that have biological activities such as anticancer effects. The aim of this study was to perform in-silico and in-vitro analysis of gallic acid derivatives (N-alkyl gallamide) as apoptosis agents for MCF7 breast cancer cells. Methods Target proteins were selected by analysis of protein-protein and drug-protein interactions. Molecular modelling was done by molecular docking. Predictive analysis of the ADMET profile of gallic acid and its derivatives (N-alkyl gallamide) was conducted using Marvin Sketch, Swissadme, protox II, and pkCSM pharmacokinetics. The selected target proteins were JUN, AKT1, CASP3, and CASP7. The MTT method was used to assess the three best compounds for their cytotoxic activity against MCF7 cells, while annexin V-FITC/PI and flow cytometry were used to analyze apoptosis. These tests were based on in-silico research. Results Compounds N-octyl gallamide, N-ters-butyl gallamide, and N-isoamyl gallamide were the three best gallic acid derivatives based on molecular modelling analysis of target proteins associated with breast cancer. The ADMET profile of the N-alkyl gallamide compound is predictable and shows a good profile as a candidate for anticancer drugs. The cytotoxic activity of the three compounds was expressed by their IC50 values of 205.2 ± 0.44 μM, 372.6 ± 4.09 μM, and 441.7 ± 1.41 μM, respectively. The apoptosis activity reaches 55 to 56% compared to control cells. Conclusion N-octyl gallamide, N-ters-butyl gallamide, and N-isoamyl gallamide have potential as an apoptosis agent of breast cancer MCF-7 Cells
The impact of smoking status on clopidogrel responsiveness in patients with coronary artery disease who undergo percutaneous coronary intervention
Authors: Aldallal Ali A. R. , Mohammad Bassim I. , Rgeeb Ahmed N. , Jamil Dina A. , Al-Aubaidy Hayder A. 
Published: August 2023

Background: Previous studies have pointed out the disproportionate action of clopidogrel in inhibiting platelet aggregation due to smoking more than ten cigarettes per a day. This study was designed to examine whether smoking enhances clopidogrel responsiveness in patients who are clinically diagnosed with coronary artery disease (CAD), following percutaneous coronary intervention (PCI). Methods: A total of 324 IHD participants were enrolled in a case-control study. Platelet function test was performed to all participants two hours before PCI procedure to measure clopidogrel response. Participants were then categorized into a non-responder group (case group n = 111) and responder group (control group n = 213). Each group was subdivided into a smoker group and a non-smoker group. All participants received clopidogrel loading dose equivalent to 600 mg and scheduled for elective PCI. Participants’ age, gender, family history of chronic illnesses was recorded in this study. Results: Smoking participants displayed a significant higher level of hemoglobin as compared to the non-smoking participants among the responder and the non-responder study groups (14.6±0.55 vs. 13.12±0.38, P < 0.029; 14.3±0.31 versus 12.96±0.39, P < 0.033) but lower AUC level (17±9 vs. 45±6, P < 0.005; 62±3 vs. 95±7, P < 0.008). Additionally, smoking intensity enhanced clopidogrel responsiveness by odd’s ratio 0.4213 at 95% C.I. (0.259 - 0.684), P < 0.0002. Conclusions: Current smokers had a good response to clopidogrel therapy which exerted a beneficial effect when undergoing PCI as compared to non-smokers. The marked difference in AUC between smokers and non-smokers could be related to the variance in hemoglobin level. The smokers’ paradox needs further justification to confirm this concept.
Analyzing the impact of loyalty card programs on customer behavior: insights from the Albanian market
Authors: Myftaraj Ervin , Trebicka Brunela 
Published: August 2023

Background: Loyalty card programs have become prevalent in the retail industry, offering various benefits and rewards to customers. This study aims to analyze the impact of loyalty card programs on customer behavior in the Albanian market. Methods: A survey was conducted among a diverse sample of customers from different retail sectors in Albania. The survey collected data on awareness, satisfaction, loyalty, and customized benefits. The survey was distributed between March and May 2023, and responses were collected electronically. The survey responses were analyzed to address the research questions and test the hypotheses. Results: The findings indicate a significant level of awareness among respondents regarding loyalty card programs. Higher satisfaction with specific benefits, such as discounts and accumulating points, is associated with higher levels of customer loyalty. Customers who reported higher frequencies of loyalty card usage demonstrated greater loyalty. Customized benefits, particularly discounts and accumulating points, significantly influenced customer satisfaction. However, other benefit categories did not show statistically significant associations with loyalty. Conclusion: The study highlights the importance of promoting loyalty card programs to enhance awareness among customers. Improving and optimizing loyalty card benefits based on customer feedback is recommended. Encouraging frequent usage of loyalty cards and personalizing benefits to align with customer preferences are key strategies to foster customer loyalty. The findings provide valuable insights for practitioners in the retail sector to enhance customer engagement, satisfaction, and loyalty.
Thickness of simple calcaneal tuberosity avulsion fractures influences the optimal fixation method employed
Authors: Wang Chunliang , Liu Shih-Jung , Chang Chung-Hsun 
Published: August 2023

AimsThis study aimed to establish the optimal fixation methods for calcaneal tuberosity avulsion fractures with different fragment thicknesses in a porcine model.MethodsA total of 36 porcine calcanea were sawed to create simple avulsion fractures with three different fragment thicknesses (5, 10, and 15 mm). They were randomly fixed with either two suture anchors or one headless screw. Load-to-failure and cyclic loading tension tests were performed for the biomechanical analysis.ResultsThis biomechanical study predicts that headless screw fixation is a better option if fragment thickness is over 15 mm in terms of the comparable peak failure load to suture anchor fixation (headless screw: 432.55 N (SD 62.25); suture anchor: 446.58 N (SD 84.97)), and less fracture fragment displacement after cyclic loading (headless screw: 3.94 N (SD 1.76); suture anchor: 8.68 N (SD 1.84)). Given that the fragment thickness is less than 10 mm, suture anchor fixation is a safer option.ConclusionFracture fragment thickness helps in making the decision of either using headless screw or suture anchor fixation in treating calcaneal tuberosity avulsion fracture, based on the regression models of our study.Cite this article: Bone Joint Res 2023;12(8):504–511.
Photonic generation of frequency-doubling Nyquist pulses using external modulation
Authors: Yuan Jin , Mei Ying , Xu Xiuxiu , Cui Jinyi , Zhang Hui , Liu Jinbo 
Published: August 2023

In this paper, an approach to generate frequency-doubling sinc-shaped optical Nyquist pulses based on external modulation is proposed and demonstrated. First, four flat optical frequency comb (OFC) lines are obtained after optical carrier suppression modulation in a dual-electrode Mach–Zehnder modulator. Then an optical interleaver is introduced to split the phase-locked OFC into two paths, of which one is transmitted to a dual-parallel Mach–Zehnder modulator for quadrupling RF modulation and another is applied to the remodulated signal to acquire comb lines with equal intervals. Thus, a phase-locked 12-line flat OFC with equal frequency intervals and corresponding Nyquist pulses is finally obtained, and Nyquist pulses at 2.5 GHz, 5 GHz, 10 GHz, and 15 GHz are achieved.
A protocol for a proof-of-concept randomized control trial testing increased protein quantity and quality in ready-to-use therapeutic food in improving linear growth among 6-23-month-old children with severe wasting in Malawi
Authors: Potani Isabel , Daniel Allison I. , Briend André , Courtney-Martin Glenda , Berkley James A. , Voskuijl Wieger , Vresk Laura , Bourdon Celine , Kathumba Sylvester , Mbale Emmie , Bandsma Robert H. J. 
Published: August 2023

Introduction
Ready-to-use therapeutic foods (RUTFs) have successfully promoted recovery from severe wasting and increased treatment coverage. However, RUTFs do not sufficiently improve linear growth, leaving many survivors of severe wasting at risk of persistent stunting, which is associated with high mortality risk, poor child development and non-communicable diseases in adulthood. High protein quantity and quality can stimulate linear growth.

Aim
The trial aims to assess whether higher-protein-RUTF leads to higher concentrations of markers of linear growth compared to standard RUTF among 6–23 months old children with severe wasting.

Methods
We designed a higher protein quantity and quality RUTF for a proof-of-concept (PoC) double-blind randomized controlled trial.

Outcomes
The primary outcome is a change in insulin-like growth factor-1 (IGF-1), a hormone positively associated with linear growth after four weeks of treatment. Secondary outcomes include changes in ponderal and linear growth and in body composition from baseline to eight weeks later; plasma amino acid profile at four weeks; acceptability and safety.

Implications
These findings will help in informing the potential impact of increased protein in RUTF on linear growth when treating severe wasting towards conducting a larger clinical trial.

Trial registration
The trial has been registered on clinicaltrial.gov (NCT05737472).
The effects of GLP-1 receptor agonists on visceral fat and liver ectopic fat in an adult population with or without diabetes and nonalcoholic fatty liver disease: A systematic review and meta-analysis
Authors: Liao Chao , Liang Xinyin , Zhang Xiao , Li Yao 
Published: August 2023

AimTo uncover the effect of GLP-1 receptor agonists (GLP-1 RAs) on the visceral- and hepatic fat content of adults.MethodsPubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception until November 2022. Randomized controlled trials (RCTs) of GLP-1Ras was extracted, including reports of effects on visceral adipose tissue and hepatic fat content in individuals with type 2 diabetes, non-type 2 diabetes, NAFLD (non-alcoholic fatty liver disease), and non-NAFLD. Meta-analyses used random-effects models.Results1736 individuals in the 30 qualified RCTs were included, comprising 1363 people with type 2 diabetes and 318 with NFLD. GLP-1 RAs reduced visceral adipose tissue (standard mean difference [SMD] = -0.59, 95% CI [-0.83, -0.36], P<0.00001) and hepatic fat content (weighted mean difference [WMD] = -3.09, 95% CI [-4.16, -2.02], P<0.00001) compared to other control treatment. Subgroup analysis showed that GLP-1Ras dramatically decreased visceral fat in patients with type 2 diabetes (SMD = -0.49, 95% CI [-0.69, -0.29] P<0.00001), NAFLD (SMD = -0.99, 95% CI [-1.64, -0.34] P = 0.003), non-type 2 diabetes (SMD = -1.38, 95% CI [-2.44, -0.32] P = 0.01), and non-NAFLD (SMD = -0.53, 95% CI [-0.78, -0.28] P<0.0001). GLP-1Ras reduced the liver fat level of type 2 diabetes (WMD = -3.15, 95% CI [-4.14, -2.15] P<0.00001), NAFLD (WMD = -3.83, 95% CI [-6.30, -1.37] P = 0.002), and type 2 diabetes with NAFLD (WMD = -4.27, 95% CI [-6.80, -1.74] P = 0.0009), while showed no impact on the hepatic fat content in non-Type 2 diabetes (WMD = −12.48, 95% CI [−45.19, 20.24] P = 0.45).ConclusionsLP-1 RAs significantly reduce visceral- and liver fat content in adults.
Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing
Authors: Malhotra Akash , Thompson Ryan , De Vos Margaretha , David Anura , Schumacher Samuel , Sohn Hojoon 
Published: August 2023

Background
Access to drug resistant testing for tuberculosis (TB) remains a challenge in high burden countries. Recently, the World Health Organization approved the use of several moderate complexity automated nucleic acid amplification tests (MC-NAAT) that have performance profiles suitable for placement in a range of TB laboratory tiers to improve drug susceptibility tests (DST) coverage.

Methods
We conducted cost analysis of two MC-NAATs with different testing throughput: Lower Throughput (LT, < 24 tests per run) and Higher Throughput (HT, upto 90+ tests per run) for placement in a hypothetical laboratory in a resource limited setting. We used per-test cost as the main indicator to assess 1) drivers of cost by resource types and 2) optimized levels of annual testing volumes for the respective MC-NAATs.

Results
The base-case per test cost of $18.52 (range: $13.79 - $40.70) for LT test and $15.37 (range: $9.61 - $37.40) for HT test. Per test cost estimates were most sensitive to the number of testing days per week, followed by equipment costs and TB-specific workloads. In general, HT NAATs were cheaper at all testing volume levels, but at lower testing volumes (less than 2,000 per year) LT tests can be cheaper if the durability of the testing system is markedly better and/or procured equipment costs are lower than that of HT NAAT.

Conclusion
Assuming equivalent performance and infrastructural needs, placement strategies for MC-NAATs need to be prioritized by laboratory system’s operational factors, testing demands, and costs.
An Empirical Study on Impact of Project Management Constraints in Agile Software Development
Authors: Sathe Chaitanya Arun , Panse Chetan 
Published: August 2023

Goal: The Study aims to investigate the impact of project management constraints in fixed-cost and fixed-scheduled Agile software development contracts using multigroup analysis (MGA) to perform repeated comparisons of parameters across groups of Scrum or Kanban methodologies using structural equation modelling (SEM)
Design/Methodology/Approach: A web-based survey is used to collect responses to a questionnaire based on project management constraints for Kanban and Scrum method-based Agile software development projects from people working on projects fixed-cost and fixed-schedule contracts and then analyzed with the help of multi-group analysis using SmartPLS 4.0
Results: Risk management has a mediating effect between project scope, resources, and delivery quality. MGA implied that the Kanban method is better at managing resources and will have a higher impact on the quality of deliverables than the Scrum method.
Limitations of the investigation: Evaluating the suitability of various multi-group analysis approaches requires more than just our empirical example using satisfactory data and other project management constraints.
Practical implications: The findings of the study suggest that hypothesis testing should be carried out for a distinct model parameter between study groups, whenever they are comparing more than two group.
Originality/Value: This study helps in contributing to exploring PLS route modelling by the introduction of the original non-parametric confidence set approach based on a comparison of parameter estimations and bootstrap confidence intervals. The study investigates the impact of several project management constraints on to fixed-cost Agile software development projects.
Postille a papiri di Caritone
Authors: Vendruscolo Fabio 
Published: August 2023

Abstract
For five lacunose passages in papyri of Chariton’s novel new reconstructions are proposed removing or harmonising divergences from the medieval codex unicus F, and in one case bringing out a new variant, possibly correct; two F readings confirmed by a papyrus, yet still usually emended or suspected, are defended with a different interpretation.
Great Doxology with Miaphysite Trisagion
Authors: Toth Peter 
Published: August 2023

Abstract
The article contains the edition and study of three ostraca in the British Library (Ostracon 5878) which join with another fragment in the Metropolitan Museum, New York (P.Mon.Epiph. 607). The join of these pieces helps to date the British Library fragments to the turn of the 6th-7th centuries and assign them to Apa Moses from the Monastery of Epiphanius in Thebes. The ostracon now provides a complete and unique text of the Great Doxology as used in the Coptic Church of the late 6th century and probably the earliest version of the so-called Constantinopolitan version of this liturgical chant.
Validation of metrological traceability of the new generation of Abbott Alinity alkaline phosphatase assay
Authors: Bianchi Giorgia , Frusciante Erika , Colombo Giulia , Infusino Ilenia , Aloisio Elena , Panteghini Mauro 
Published: August 2023

Abstract

Objectives
Recently, Abbott Diagnostics marketed a new generation of Alinity enzyme assays, introducing a multiparametric calibrator [Consolidated Chemistry Calibrator (ConCC)] in place of or in addition to factor-based calibrations. For alkaline phosphatase (ALP), both calibration options are offered, i.e., with ConCC (ALP2) and with an experimental calibration factor (ALP2F). Both options are declared traceable to the 2011 IFCC reference measurement procedure (RMP). Before to replace the old generation (ALP1) with the new one, we decided to validate the trueness of ALP2/ALP2F.

Methods
Three approaches were employed: (a) preliminary comparison on 48 native frozen serum samples with ALP1, of which traceability to RMP was previously successfully verified; (b) examination of three banked serum pools (BSP) with values assigned by RMP; (c) direct comparison with RMP on a set of 24 fresh serum samples. Bias estimation and regression studies were performed, and the standard measurement uncertainty associated with ALP measurements on clinical samples (uresult) was estimated and compared with established analytical performance specifications (APS). ConCC commutability was also assessed.

Results
A positive proportional bias was found with both ALP2 and ALP2F when compared to ALP1 and RMP. This positive bias was confirmed on BSP: in average, +13.1 % for ALP2 and +10.0 % for ALP2F, respectively. uresult were 13.28 % for ALP2 and 10.04 % for ALP2F, both not fulfilling the minimum APS of 4.0 %. Furthermore, ConCC was not commutable with clinical samples.

Conclusions
Our results unearth problems in the correct implementation of traceability of Alinity ALP2/ALP2F, with the risk for the new assay to be unfit for clinical purposes.
Lexical borrowing in Korean: a diachronic approach based on a corpus analysis
Authors: Oh Yoonjung , Son Hyunjung 
Published: August 2023

Abstract
Loanwords are lexical terms borrowed from foreign languages by transliterating the original sound of the borrowed words with the recipient language’s consonants and vowels. This paper focuses on lexical borrowing in the Korean language from a diachronic perspective. Based on approximately 9,500 Korean loanwords extracted from a corpus of women’s magazine articles of residential sections (the Korean Contemporary Residential Culture Corpus), we investigated the alteration of loanword usage from 1970 to 2015. Having introduced our definition of Korean loanwords in phonological and morphological terms, we performed statistical analysis particularly with type/token frequency and cultural/core loanwords, along with semantic analysis with Period Representative Loanword (PRL). We argue that, in addition to its gradual and rapid increase over time, Korean loanword usage underwent a remarkable evolution in the 1990s.
Strichartz inequality for orthonormal functions associated with special Hermite operator
Authors: Ghosh Sunit , Mondal Shyam Swarup , Swain Jitendriya 
Published: August 2023

Abstract
In this article, we derive the restriction theorem for the special Hermite transform and obtain the Strichartz estimate for the system of orthonormal functions associated with the special Hermite operator. Further, we discuss the optimal behavior of the constant as a limit of a large number of functions.
High isolation frequency-reconfigurable UWB-MIMO antenna with on-demand WiMAX band elimination
Authors: Saleem Summaiyya , Bhatnagar Deepak , Kumari Sarita , Siddiqui Mohd Gulman , Yadav Dinesh 
Published: August 2023

Abstract
In this article, a planar dual-element frequency reconfigurable multiple-input multiple-output (MIMO) antenna for ultra-wideband (UWB) applications is studied. The frequency band can be switched between UWB operation and single band rejected UWB performance using a pair of PIN diodes in the MIMO configuration. The presented antenna is comprised of two similar slotted circular radiators, having tapered microstrip feedlines and separate partial ground planes. An RT/Duroid 5880 substrate with size 54 × 54 mm2 is used for the design purpose. Rotational symmetry between the radiators and diagonally oriented t-shaped decoupling structure behind the substrate have been utilized for high isolation purpose. The designed MIMO antenna exhibits UWB performance in mode 1. In other mode, the antenna operates in the frequency range 2.46–10.44 GHz with Worldwide Interoperability for Microwave Access (WiMAX) band rejection. Thus, the MIMO antenna exhibits on-demand single band rejection behavior depending on the switching conditions of the diodes. The measured isolation is greater than −20 dB in both the modes. The presented MIMO configuration possesses compact and planar geometry with high gain, good isolation, ultrawideband performance with reconfigurable band elimination, high efficiency and efficient diversity performance parameters. The suggested antenna is a good choice to be utilized for portable UWB MIMO applications.
Monotone operators and a class of nonlinear elliptic equations on the Sierpiński gasket
Authors: Verma Amar Pal , Kar Rasmita 
Published: August 2023

Abstract
We study the existence of solutions for the nonlinear elliptic problem

-

Δ
⁢
v

-

λ
⁢

g
1

⁢
v

+

h
1

⁢

(
v
)

=

f
1

\displaystyle-\Delta v-\lambda g_{1}v+h_{1}(v)=f_{1}

in
⁢
V

∖

V
0

,

\displaystyle\phantom{}\text{in }V\setminus V_{0},

v
=
0

\displaystyle v=0

on
⁢

V
0

,

\displaystyle\phantom{}\text{on }V_{0},

where V is the Sierpiński gasket in

ℝ

N
-
1

{\mathbb{R}^{N-1}}

(

N
≥
2

{N\geq 2}

),

V
0

{V_{0}}

is its boundary (consisting of its N corners) and

λ
∈
ℝ

{\lambda\in\mathbb{R}}

. Here

f
1

,

g
1

:

V
→
ℝ

{f_{1},g_{1}:V\to\mathbb{R}}

,

h
1

:

ℝ
→
ℝ

{h_{1}:\mathbb{R}\to\mathbb{R}}

are the maps satisfying suitable hypotheses.