bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of umbrella-shaped layout for trocar puncture in pure laparoscopic partial nephrectomy with retroperitoneal approach
Authors: Ma Zhen , Chen Fangmin , Yu Dahai , Li Kai , Li Song , Tang Shuai , Wang Qi , Shi Huiyuan 
Published: July 2023

Abstract
Background
Laparoscopic partial nephrectomy (LPN) is one of the main methods for treating renal cancer. There are many types of puncture hole layouts, and umbrella layouts are less commonly used. This study aimed to investigate the efficacy and safety of retroperitoneal LPN with an umbrella-shaped layout for localized renal cell carcinoma.
Methods
Eighty patients with stage T1a renal cancer who were admitted to our hospital from May 2017 to March 2021 and underwent retroperitoneal LPN were selected. Patients were divided into two groups according to the position of the puncture hole: Trapezoidal layout group and umbrella-shaped layout group. Demographic and clinical data were retrospectively analyzed.
Results
The warm ischemia times, operative times, and amount of blood loss for the trapezoidal and umbrella-shaped layout groups were 19.8 min and 15.8 min, 96.9 min and 85.0 min, and 86.2 ml and 73.5 ml, respectively; the differences were statistically significant (P < 0.05). The postoperative complication rates of the trapezoidal and umbrella-shaped layout groups were 20% (8/40) and 17.5% (7/40), respectively. The postoperative hospitalization periods of the trapezoidal and umbrella-shaped layout groups were 9.1 days and 8.9 days, respectively. At 6 months after surgery, the glomerular filtration rates (GFR) of the affected side of the trapezoidal and umbrella-shaped layout groups were decreased by 10.3 ml/min·1.73 m2 and 9.6 ml/min·1.73 m2; the differences were not statistically significant (P > 0.05). All pathological margins were negative. During postoperative follow-up, there was one case of recurrence in the trapezoidal layout group and no recurrence in the umbrella-shaped layout group.
Conclusion
The umbrella-shaped layout is safe and effective for retroperitoneal LPN and superior to the trapezoidal layout in terms of operative time, warm ischemia time, and blood loss.
Coblation revolving tonsillectomy with outside-in dissection: A modified tonsillectomy
Authors: Lou Zhengcai , Lou Zihan , lv tian , chen zhengnong 
Published: July 2023

Abstract
Objective
This study introduces a modified tonsillectomy procedure and evaluates the occurrence of intraoperative and postoperative hemorrhage using the new method.
Methods
Modified tonsillectomy, defined as coblation revolving tonsillectomy with outside-in dissection, was performed on 104 patients.
Results
This study enrolled 104 patients (62 males and 42 females), the average age was 23.6 ± 6.8 (range: 16–31) years. The reasons for the procedure were as follows: 58 (55.8%) due to tonsillar hypertrophy, 39 (37.5%) for recurrent tonsillitis, and 7 (6.7%) because of the presence of a benign tumor. The average operation time of bilateral surgery was 13.2 ± 1.9 min. No intraoperative bleeding was encountered in the tonsillar fossa in any of the patients. Pain intensity was 4.1 ± 1.6 on postoperative days 0, 3.9 ± 2.1 on postoperative days 1, and 2.8 ± 1.1 on postoperative days 2. No postoperative hemorrhage which required any additional intervention occurred. Also, no postoperative other complications were encountered.
Conclusions
Coblation revolving tonsillectomy with outside-in dissection may be effective and safe technique for reducing intraoperative and postoperative hemorrhage.
Interpreting the effects of firefly algorithm (FA) to optimize varying machine learning models for the prediction of rock joint shear strength
Authors: Wang Qiang , Qi Jiali , Wu Baixuan , Cheng Tao , Xie Yongjian , Nie Guihai , Zheng Yuqi , Chen Zeyang , Wu Kuanghuai , Fiorentini Nicholas , Huang Jiandong 
Published: July 2023

Abstract
To propose an effective and accurate model for the prediction of the shear strength of rock mass joint, the present study focuses on the comparison of different machine learning (ML) models, including the support vector machine (SVM), decision tree (DT), random forest (RF), K-nearest neighbors (KNN), and mixed logistic regression (MLR) models. The firefly algorithm (FA) was employed to tune the hyper-parameters of the ML algorithms, using the input parameters of the joint roughness, compressive strength, normal stress, and friction angle. The prediction performance showed that the developed model can effectively and reliably tune the hyper-parameters of the ML algorithm and arrive at the optimal structure to estimate the shear strength of the rock mass joint. Among the five ML algorithms aiming for the estimation of the shear strength, the root mean square error (RMSE) values (the training set is 0.08 and the testing set is 0.1854) of the SVM model are the lowest, and the correlation coefficient (R) values (the training set is 0.9861 and the testing set is 0.9457) are the highest, and there is no over-fitting in the prediction process. Response analysis shows that normal stress is the most influential coefficient affecting the rock mass joint shear strength, while compressive stress is the least.
The effect of a political crisis on performance of community- and state-managed forests in Madagascar
Authors: Neugarten Rachel , Rasolofoson Ranaivo , Barrett Christopher , Vieilledent Ghislain , Rodewald Amanda 
Published: July 2023

Abstract
Understanding the effectiveness of conservation interventions during times of political instability is important given how much of the world’s biodiversity is concentrated in politically fragile nations. We investigated the effect of a political crisis on the relative performance of community managed forests versus state-managed protected areas in terms of reducing deforestation in Madagascar, a biodiversity hotspot. We used remotely sensed data and statistical matching within an event study design to isolate the effect of the crisis and post-crisis period on performance. Annual rates of deforestation accelerated at the end of the crisis and were higher in community forests than in state-managed areas. After controlling for differences in location and other confounding variables, we found no difference in performance during the crisis, but community-managed forests performed worse in post-crisis years. These findings suggest that, as a political crisis subsides and deforestation pressures intensify, community-based conservation may be less resilient than state protection.
An Overview of the Anti-HIV Potential of Thiazolidinone Derivatives
Authors: Abid Fatma Mohamed A. , Salim Nurul Syahirah , Wahab Roswanira Abdul , Hashim Siti Ernieyanti , Sankaranarayanan Murugesan , Bhat Ajmal , Jamalis Joazaizulfazli 
Published: July 2023

Abstract:Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syn-drome (AIDS), an immunosuppressive, life-threatening condition that frequently results in other potentially fatal opportunistic infections in affected patients. Despite advancements in anti-retro-viral therapy, AIDS remains the main reason for worldwide mortality. Although various anti-HIV drugs have profoundly enhanced the quality of life for AIDS patients, some patients develop re-sistance to the drugs, and the long-term anti-HIV treatments, and their adverse effects, prevail as major therapeutic failure causes. Therefore, concerted efforts by the scientific community are cru-cial to identifying new candidates for anti-HIV therapies. In this respect, the thiazolidinone moiety has acquired prominence in drug discovery and development due to its antifungal, antiviral, anti-depressant, anticancer, and antibacterial properties. This moiety also demonstrated significant anti-HIV activity as a core heterocycle or derivative of substituted heterocycles. To expedite the syn-thesis of more novel anti-HIV drugs containing a thiazolidinone nucleus, we compiled a list of thiazolidinone-containing previously documented anti-HIV compounds. We hope that this could serve as a guide for future researchers in their design of effective thiazolidine-containing com-pounds showing anti-HIV activity.
Caracterización y uso potencial de la vaina de Ebenopsis ebano para diseñar alternativas de aprovechamiento integral
Authors: Morales-Salvatierra Andrés , Rodríguez-Castillejos Guadalupe , Santiago Adame Rubén , Lizarazo-Ortega Cristian , Castillo-Ruíz Octelina , Ruíz-Salazar Régulo , Alvarado-Reyna Sofía 
Published: July 2023

El árbol del ébano (Ebenopsis ebano (Berl.) Britton et Rose) tiene como fruto una vaina conocida, las semillas dentro de la vaina tienen un alto contenido proteico. Pese a su amplia distribución y cantidad en el noreste de México, no se ha registrado algún uso para la vaina, convirtiéndose en un residuo. Por ello, el objetivo de este trabajo fue evaluar las propiedades físicas, químicas y funcionales de la vaina de ébano y generar información útil a las comunidades para el aprovechamiento integral de árbol como suplemento en alimentación animal, fermentaciones industriales o fuente de antioxidantes. Se encontró que la vaina tuvo longitud promedio de 10.16 cm, diámetro de 14.85 cm, ancho de 0.54 cm y peso de 5.19 g En cuanto a las características físicas y proximales, la absorción de agua fue de 50%, absorción de aceite 1.89%, densidad 0.53 g/cm3. Los parámetros de color fueron L* 56.6, a* 8.07, b* 26.78, mientras que el contenido proximal fue 2.40% humedad, 30.9% cenizas, 0.56% grasa, 47.7% fibra, 45.2 carbohidratos y 1% proteína. Se encontró también que la máxima concentración de xilosa (33.8 g) se obtuvo con 6% de H2SO4. Los resultados indican que este residuo puede utilizarse como fuente de fibra para suplementación animal, o bien aprovechar la xilosa para medios de cultivo económicos a escala industrial o, incluso, la obtención de polifenoles a partir de extractos orgánicos.
Therapeutic aspects of biologically potent vanillin derivatives: A critical review
Authors: Senthil Kumar Raju , Naveena Sundhararajan , Praveen Sekar , Yogadharshini Nagalingam 
Published: July 2023

4-hydroxy 3-methoxy benzaldehyde (Vanillin) is an aromatic phenolic aldehyde with unique chemical properties and pharmacological impact. Because of its potent nature, it acts as a lead for drug discovery and development techniques. Heterocyclic compounds with vanillin moiety were efficacious and thrive against many emerging infectious diseases, which can also lead to develop numerous fused heterocyclic vanillin derivatives and various heterocyclic compounds such as pyrimidines, quinoxalines, imidazoles or thiazoles. Greener-mediated synthesis is a sustained chemical reaction used to synthesize hazardless vanillin derivatives with a high yield of product in desired time. Due to its several reasonable modifications with high bioactivity, vanillin moiety can be used to develop various potent derivatives like vanillin-based ferrocenyl chalcone derivatives, vanillin-hydrazone derivatives, Schiff base and Mannich base-based derivatives, pyrazoline vanillin-based derivatives, triazole-based vanillin derivatives and vanillin hybrids plays a crucial role in the coordination chemistry. These derivatives exhibited plenty of biological applications, which include anticancer, antioxidant, antibacterial, antitubercular, antimalarial, antiviral, anti-inflammatory, anti-Alzheimer and anti-diabetic effects. Hence, this review focuses on the significance of vanillin derivatives responsible for biological activity.
Keywords: Vanillin; 4-hydroxy 3-methoxy benzaldehyde; Vanillin derivatives; Antimicrobial; Anticancer; Biological applications
Aktualny i przewidywany stan rynku mięsa wieprzowego na świecie
Authors: Stępień Sebastian 
Published: July 2023

Rynek mięsa wieprzowego jest wiodącym rynkiem mięsnym na świecie pod względem wielkości podaży i popytu, wysoki jest też udział tego surowca w handlu zagranicznym. W najbliższych latach znaczenie branży dla gospodarki światowej będzie wzrastać, z uwagi na rozwój produkcji w krajach rozwijających się i wzrost zapotrzebowania na surowiec jako rezultat przyrostu liczby ludności, zwiększającej się zamożności części krajów na świecie i zmiany struktury konsumpcji. Z drugiej strony zaobserwować można pewne czynniki ograniczające rozwój ryku, takie jak rosnące koszty produkcji żywca wieprzowego, wymogi w zakresie środowiska naturalnego lub zmiany klimatyczne. Celem pracy jest zaprezentowanie bieżącej sytuacji w produkcji i handlu zagranicznym na rynku mięsa wieprzowego na świecie oraz wskazanie możliwego kierunku zmian do roku 2020, na tle uwarunkowań globalnych. Praca ma charakter przeglądowy, z elementami wnioskowania dedukcyjnego.
Behavioral and histopathological changes of Clarias gariepinus as a predatory fish against Culex pipiens larvae following exposure to sublethal concentration of quinclorac and bensulfuron-methyl based herbicide
Authors: Mohamed I.A. , Fathy M. , Farghal A.I.A. , Temerak S.A.H. , Abd El-Ghaffar S.Kh. , Idriss S.K.A. 
Published: July 2023

Summary

Clarias gariepinus is one of the widespread culturable freshwater fish species in Africa, which is prevalent in various natural and human-made aquatic habitats including rice-fish system. This fish species displays predation potential on the aquatic stages of mosquitoes. Bensulfuron-methyl and quinclorac are herbicide active substances that have been extensively applied in rice culture in Egypt and other countries worldwide. This study assessed the adverse effects of sublethal concentration of a commercial herbicide formulation containing quinclorac and bensulfuron-methyl on the predation potential of C. gariepinus female and male predatory fish on Culex pipiens mosquito larvae. Also, stomach and intestine histopathology of the treated fish was investigated. The exposure of C. gariepinus to sublethal concentration of quinclorac and bensulfuron-methyl based herbicide produced detrimental effects on prey consumption and histopathological changes in the stomach and intestine of the fish. The mosquito consumption by the treated female and male fish decreased significantly compared to the untreated fish of both sexes. The histological changes in the intestines were hyperplasia of the intestinal epithelium and goblet cells; edema of lamina propria and broad intestinal villi, and distortion in intestinal villi in comparison to control. The stomach histopathology changes were necrosis and sloughing of mucosal epithelium with severe damage of sub-mucosa. Thus, the tested herbicide at sublethal concentration on C. gariepinus decreased the prey consumption on mosquito larvae and caused histopathological alterations in the fish that may impair its digestive physiology. These findings suggest a threat of the tested herbicide to C. gariepinus survival and potential as a native successful biocontrol agent against Cx. pipiens larvae.
Simulation of an Impact on an Aramid Fabric Panel by A .357 Projectile
Authors: Chiper Titire Larisa , Ojoc George Ghiocel , Popescu Christian , Deleanu Lorena 
Published: July 2023

Abstract
This paper presents a model for impact bullet – panel of woven aramid fabrics in order to use it for an initial assessment of similar panels to protect against bullets in a range of 100…800 m/s. Based on these initial simulations, the designer could select the number of layers for actual tests. The factors that could be varied in these simulations could be the shape and dimensions of the projectiles, their mass and impact velocity. It is presented only the case of impacting a panel with .357 Magnum, with an incidence velocity of 420 m/s. The panel is composed of 8 layers of plain woven fabrics (200 mm x 200 mm), with weft and warp yarns, the yarn geometry being close to Teijin CT736 phenolic fabric, with 1680 DTEX and 410 g/m2. The simulation helps to identify the stages of panel failure and to evaluate qualitatively the similarity in panel failure with that of the actual panel, tested under the same conditions as the model.
Study of Methods and Techniques for Manipulating the Time Synchronization Component of NTP Servers in Computer Networks
Authors: Romaniuc Alexandru-Gabriel , Vasile Vlad-Cosmin , Borda Elena-Monica 
Published: July 2023

Abstract
In computer networks as well as in many other domains, time synchronization is carried out by some dedicated devices called time servers that uses network protocols, such as NTP (Network Time Protocol), PTP (Precision Time Protocol) or SNTP (Simple Network Time Protocol). Many domains and applications, such as, computer networks, security protocols, telecommunications, network services, and many others, depend on accurate time synchronization. According to the CVE (Common Vulnerabilities and Exposures) databases, between 2001-2022, more than 150 time synchronization protocols vulnerabilities have been reported. One of the most dangerous threats is the manipulation of the time synchronization information. Thus, the existence of such a vulnerability can generate serious security problems. Considering these aspects, in this article we aim to use some methods and techniques for the manipulation of the time component and use them to test some synchronization systems. This will require real-life scenarios of the use of time synchronization systems in which some methods and techniques are applied to exploit their vulnerabilities. Following these scenarios, we will be able to assess the risk to which these systems are exposed.
The interleukin-1 receptor type-1 in disturbed flow-induced endothelial mesenchymal activation
Authors: Kidder Evan , Pea Meleah , Cheng Siyuan , Koppada Satya-Priya , Visvanathan Suren , Henderson Quartina , Thuzar Moe , Yu Xiuping , Alfaidi Mabruka 
Published: July 2023

IntroductionAtherosclerosis is a progressive disease that develops in areas of disturbed flow (d-flow). Progressive atherosclerosis is characterized by bulky plaques rich in mesenchymal cells and high-grade inflammation that can rupture leading to sudden cardiac death or acute myocardial infarction. In response to d-flow, endothelial cells acquire a mesenchymal phenotype through endothelial-to-mesenchymal transition (EndMT). However, the signaling intermediaries that link d-flow to EndMT are incompletely understood.Methods and ResultsIn this study we found that in human atherosclerosis, cells expressing SNAI1 (Snail 1, EndMT transcription factor) were highly expressed within the endothelial cell (EC) layer and in the pre-necrotic areas in unstable lesions, whereas stable lesions did not show any SNAI1 positive cells, suggesting a role for EndMT in lesion instability. The interleukin-1 (IL-1), which signals through the type-I IL-1 receptor (IL-1R1), has been implicated in plaque instability and linked to EndMT formation in vitro. Interestingly, we observed an association between SNAI1 and IL-1R1 within ECs in the unstable lesions. To establish the causal relationship between EndMT and IL-1R1 expression, we next examined IL-1R1 levels in our Cre-lox endothelial-specific lineage tracing mice. IL-1R1 and Snail1 were highly expressed in ECs under atheroprone compared to athero-protective areas, and oscillatory shear stress (OSS) increased IL-1R1 protein and mRNA levels in vitro. Exposure of ECs to OSS resulted in loss of their EC markers and higher induction of EndMT markers. By contrast, genetic silencing of IL-1R1 significantly reduced the expression of EndMT markers and Snail1 nuclear translocation, suggesting a direct role for IL-1R1 in d-flow-induced EndMT. In vivo, re-analysis of scRNA-seq datasets in carotid artery exposed to d-flow confirmed the IL-1R1 upregulation among EndMT population, and in our partial carotid ligation model of d-flow, endothelial cell specific IL-1R1 KO significantly reduced SNAI1 expression.DiscussionGlobal inhibition of IL-1 signaling in atherosclerosis as a therapeutic target has recently been tested in the completed CANTOS trial, with promising results. However, the data on IL-1R1 signaling in different vascular cell-types are inconsistent. Herein, we show endothelial IL-1R1 as a novel mechanosensitive receptor that couples d-flow to IL-1 signaling in EndMT.
Clinicopathological characteristics and prognostic analysis of breast cancer with a hormone receptor status of ER(-)/PR(+)
Authors: Wang Xinli , Xue Yan 
Published: July 2023

BackgroundIt is unknown whether ER(-)/PR(+) breast cancer is an independent breast cancer subtype, how it differs from other subtypes, and what its significance is regarding treatment and prognosis. This study compared ER(-)/PR(+) breast cancer with other subtypes to better understand the biological characteristics and prognosis of ER(-)/PR(+) breast cancer, to guide clinical treatment and establish a theoretical foundation.MethodsWe retrospectively analyzed data for patients diagnosed with breast cancer in the Surveillance, Epidemiology, and End Results (SEER) database. The clinicopathological characteristics of ER(-)/PR(+) breast cancer, including age, tumor size, lymph node status, HER-2 status, pathological type and histological grade, were compared with other types of breast cancer. A risk scoring system was developed based on independent risk factors influencing prognosis to predict the patient’s prognosis, and a nomogram model was created to predict the patient’s survival rate. Receiver operating characteristic curve (ROC) and calibration curve was used to evaluate the predictive performance of the nomogram.ResultsThe rates of T3-4, lymph node positivity, HER-2 positivity, infiltrating non-special pathological type, and G3 were significantly higher in ER(-)/PR(+) than in ER(+)/PR(+) cancer (p &lt;0.001). ER(-)/PR(+) was similar to biological activity of ER(-)/PR(-) type. ER(-)/PR(+)/HER-2(+) patients had a better survival prognosis than ER(-)/PR(+) HER-2(-) patients (p&lt;0.05). The prognosis of ER-/PR+ breast cancer was significantly associated with age, HER-2 status, and T stage.ConclusionER(-)/PR(+) breast cancer is more similar to ER(-)/PR(-) breast cancer than other breast cancer subtypes, with an early age of onset, a high proportion of infiltrating non-special types, a high histological grade, and a high HER-2 positivity rate. Whether HER-2 positivity can improve the prognosis of ER(-)/PR(+)breast cancer is worth further discussion. The risk scoring system we developed can effectively distinguish between high-risk and low-risk patients. The nomogram we created had a concordance index of 0.736, and the calibration curve showed good agreement between the predicted and observed outcomes.