bluuebunny/crossref_metadata_2025_split huggingface dataset:
Food texture and vitaminDinfluence mouse mandible form and molar roots
Authors: Van Ankum Elsa M. , Majcher Kadin B. , Dolovich Allan T. , Johnston James D. , Flegel Kennedy P. , Boughner Julia C. 
Published: September 2023

AbstractIndustrialization influenced several facets of lifestyle, including softer nutrient‐poor diets that contributed to vitamin D deficiency in post‐industrzialized populations, with concomitantly increased dental problems. Here we simulated a post‐industrialized diet in a mouse model to test the effects of diet texture and vitamin D level on mandible and third molar (M3) forms. Mice were raised on a soft diet with vitamin D (VitD) or without it (NoD), or on a hard diet with vitamin D. We hypothesized that a VitD/hard diet is optimal for normal mandible and tooth root form, as well as for timely M3 initiation. Subsets of adult NoD/soft and VitD/soft groups were bred to produce embryos that were micro‐computed tomography (μCT) scanned to stage M3 development. M3 stage did not differ between embryos from mothers fed VitD and NoD diets, indicating that vitamin D does not affect timing of M3 onset. Sacrificed adult mice were μCT‐scanned, their mandibles 3D‐landmarked and M3 roots were measured. Principal component (PC) analysis described the largest proportion of mandible shape variance (PC1, 30.1%) related to diet texture, and nominal shape variance (PC2, 13.8%) related to vitamin D. Mice fed a soft diet had shorter, relatively narrower, and somewhat differently shaped mandibles that recapitulated findings in human populations. ANOVA and other multivariate tests found significantly wider M3 roots and larger root canals in mice fed a soft diet, with vitamin D having little effect. Altogether our experiments using a mouse model contribute new insights about how a post‐industrial diet may influence human craniodental variation.
Statin use, survival and incidence of thrombosis among older patients with polycythemia vera and essential thrombocythemia
Authors: Podoltsev Nikolai A. , Wang Rong , Shallis Rory M. , Stempel Jessica M. , Di Mengyang , Neparidze Natalia , Zeidan Amer M. , Huntington Scott F. , Giri Smith , Hull Sarah C. , Gore Steven D. , Ma Xiaomei 
Published: September 2023

AbstractBackgroundPolycythemia vera (PV) and essential thrombocythemia (ET) are linked to increased risk of cardiovascular morbidity and mortality. In addition to the reduction in of arterial thrombotic events, statins may prevent venous thrombosis including among patients with cancer. As previous registry‐ and claims‐based studies revealed that the use of statins may improve the survival of patients with various malignancies we evaluated their impact on outcomes of older adults with PV and ET.MethodsWe identified 4010 older adults (aged 66–99 years at diagnosis) with PV (n = 1809) and ET (n = 2201) in a population‐based cohort study using the Surveillance, Epidemiology, and End Results‐Medicare database with median follow‐up of 3.92 (interquartile range: 2.58–5.75) years. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) approaches were utilized to assess potential association between statins and overall survival. Multivariable competing risk models with death as a competing risk were used to evaluate possible relationship between statins and the incidence of thrombosis.Results55.8% of the patients used statins within the first year after PV/ET diagnosis, and statin use was associated with a 22% reduction in all‐cause mortality (PSM: hazard ratio [HR] = 0.78, 95% confidence interval [CI]: 0.63–0.98, p = 0.03; IPTW: HR = 0.79, 95% CI: 0.64–0.97, p = 0.03). Statins also reduced the risk of thrombosis in this patient population (PSM: HR = 0.63, 95% CI: 0.51–0.78, p < 0.01; IPTW: HR = 0.57, 95% CI: 0.49–0.66, p < 0.01) as well as in PV and ET subgroups.ConclusionsThese findings suggest that it may be important to incorporate statins into the therapeutic strategy for older adults with PV and ET.
Discrete emotions effect on consumer evaluation and behaviour: A contextual perspective and directions for future research
Authors: Aeron Suchi , Rahman Zillur 
Published: September 2023

AbstractEmotions are the focal factor influencing consumer evaluation and behaviour. However, the present literature remains fragmented owing to conflicting findings on effects of emotions. Identifying moderator(s) of emotion's effect resolves these inconsistencies and helps comprehend when emotions are effective marketing tools. This study jointly reviews the literature on eight discrete emotions spanning over two decades (2000–2021), synthesizing and analysing the research on moderators attenuating, intensifying, or even reversing the effect of discrete emotions, documenting them at an individual and situational level. Based on that, an integrated contextually bounded emotion effect framework is advanced that resolves inconsistencies in literature and enables us to (1) draw instructive insights around discrete emotion dynamic effects owing to contextual variability, (2) identify similarities/differences within/across emotions and contextual factors (3) provide research‐informed managerial implication and directions for future research.
Targeting AKT2 in MDA‐MB‐231 Cells by Pyrazole Hybrids: Structural, Biological and Molecular Docking Studies
Authors: Gaikwad Sanjay S. , Nimal Snehal K. , Pol Rushikesh , Markad Datta , Jadhao Amardeep R. , Jadhav Umesh , Kate Anup N. , Gacche Rajesh N. , Patil Limbraj R. , Chikate Rajeev C. 
Published: September 2023

AbstractPyrazolic hybrids appended with naphthalene, p‐chlorobenzene, o‐phenol and toluene have been synthesized using Claisen Schmidt condensation reaction of 1‐benzyl‐3,5‐dimethyl‐1H‐pyrazole‐4‐carbaldehyde. All compounds were characterized by various spectroscopic techniques. Compound (E)‐3‐(1‐benzyl‐3,5‐dimethyl‐1H‐pyrazol‐4‐yl)‐1‐(4‐chlorophenyl)prop‐2‐en‐1‐one crystallizes in monoclinic crystal system with C2/c space group. These synthesized compounds were tested for cytotoxic activity and among these compounds 4b and 5a shows prominent cytotoxic activity against triple‐negative breast cancer (TNBC) cells MDA‐MB‐231 with IC50 values 47.72 μM and 24.25 μM, respectively. Distinguishing morphological changes were noticed in MDA‐MB‐231 cells treated with pyrazole hybrids contributing to apoptosis action. To get more insight into cytotoxic activity, in silico molecular docking of these compounds were performed and the results suggested that (E)‐3‐(1‐benzyl‐3,5‐dimethyl‐1H‐pyrazol‐4‐yl)‐1‐(p‐tolyl)prop‐2‐en‐1‐one and 1‐(1′‐benzyl‐5‐(4‐chlorophenyl)‐3′,5′‐dimethyl‐3,4‐dihydro‐1′H,2H‐[3,4′‐bipyrazol]‐2‐yl)ethan‐1‐one binds to the prominent domain of Akt2 indicating their potential ability as Akt2 inhibitor. Moreover, from in silico ADME studies clearly demonstrated that these compounds may be regarded as a drug candidate for sub‐lingual absorption based on log p values (2.157–4.924). These compounds also show promising antitubercular activity. The overall results suggest that pyrazolic hybrids with substitution at less sterically hindered positions have appealing potent cytotoxic activity and antituberculosis activity due to which they may act as multidrug candidate.
Heterobimetallic Complexes Bridged by an Unsymmetrical Bis(NHC) Ligand: Study of Enhanced Catalytic Activity in Tandem Transformations and Understanding of Cooperativity between the Metal Centers
Authors: Kumar Shashi , Patra Deeptesh K. , Rit Arnab 
Published: September 2023

AbstractThe bis(azolium) salt [L1‐H2]Br2 was found to serve as a suitable platform for accessing the heterobimetallic IrIII‐M (M=PdII/AuI) and PdII‐IrIII complexes. Initially, selective mono‐metalation of [L1‐H2]Br2 yielded an orthometalated IrIII‐ or non‐orthometalated PdII‐complex. Sequential metalation of the mono‐IrIII complex resulted in the formation of heterobimetallic IrIII‐PdII/AuI complexes. Similarly, a distinct heterobimetallic PdII‐IrIII complex was synthesized starting from the mono‐PdII complex. Further, the corresponding homobimetallic IrIII‐IrIII and PdII‐PdII complexes were directly obtained from [L1‐H2]Br2. Additionally, monometallic PdII and IrIII analogues were synthesized from [L2‐H]Br and [L3‐H]Br, respectively. The heterobimetallic IrIII‐PdII and PdII‐IrIII complexes were then evaluated as catalysts in various one‐pot tandem catalytic reactions in which they demonstrated superior activity than the mixtures of both their corresponding homobimetallic IrIII‐IrIII/PdII‐PdII and monometallic IrIII/PdII counterparts, under the constant concentrations of metal centers. Moreover, while comparing complexes IrIII‐PdII and PdII‐IrIII, the former exhibits higher activity in all the studied reactions. All these findings suggest the presence of some form of cooperativity between the two metal centers (Ir and Pd) connected by a single ligand framework in IrIII‐PdII and PdII‐IrIII complex, with IrIII‐PdII displaying better cooperativity that has been validated by electrochemical, NMR, and DFT studies.
Panchromatic Light‐Capturing Bis‐styryl BODIPY‐Perylenediimide Donor–Acceptor Constructs: Occurrence of Sequential Energy Transfer Followed by Electron Transfer
Authors: Ileperuma Chamari V. , Garcés‐Garcés José , Shao Shuai , Fernández‐Lázaro Fernando , Sastre‐Santos Ángela , Karr Paul A. , D'Souza Francis 
Published: September 2023

AbstractInvited for the cover of this issue are the groups of Fernando Fernández‐Lázaro and Ángela Sastre‐Santos at the Universidad Miguel Hernández, Elche, Spain, and Francis D'Souza at the University of North Texas at Denton, Texas, USA. The image depicts the structure and properties of bis‐styryl BODIPY‐perylenediimide donor–acceptor constructs. Read the full text of the article at 10.1002/chem.202301686.
Structure challenges in the multivalency of Tau‐microtubule interactions
Authors: Nogales Eva , Kellogg Elizabeth 
Published: September 2023

AbstractStructural studies aiming to visualize the interaction of Tau with microtubules (MTs) face several challenges, the main concerning the fact that Tau has multiple MT‐interacting regions. In particular, the four (or three) pseudo‐repeats of Tau bind to identical elements along the MT lattice but do it through non‐identical residues. In addition, any given Tau molecule can use all its repeats or just one for its engagement with MTs. Finally, the binding of one Tau is not necessarily in register with respect to the next one. The mismatch in the MT and Tau repeats, therefore, challenges conventional modes of image analysis when visualizing these samples using cryo‐electron microscopy. This commentary is dedicated to those challenges and ways to circumvent them while aiming for an atomic description of the Tau‐tubulin interaction.
Prospective evaluation of implants‐supported, tooth‐implant supported, and teeth‐supported 3‐unit posterior monolithic zirconia fixed restorations: Bite force and patient satisfaction
Authors: Altayyar Sadeq , Al‐zordk Walid , Algabri Radwan , Rajah Eshraq , Al‐baadani Abdulsattar , Alqutaibi Ahmed Yaseen , Madina Manal Abo , Ghazy Mohammed H. 
Published: September 2023

AbstractObjectivesThis study aimed to evaluate the maximum bite force (MBF) and satisfaction of patients restored with implants, combined tooth‐implants, and teeth‐supported monolithic zirconia fixed dental prostheses (FDPs).Materials and MethodsThirty partially edentulous patients in need of three units of FDPs in their mandibular posterior region were divided into three equal groups (n = 10) as follows: Group‐1 patients received two implants for each at the second premolar and second molar regions, Group‐2 patients received one implant for each at the second molar region, and Group‐3 patients with missing lower first molar. All the restorations were constructed from monolithic zirconia. Patients were evaluated 1 week after placement of restorations (baseline) and then after 6, 12, and 24‐month intervals for MBF using force transducer occlusal force meter and satisfaction (function, esthetic, and overall satisfaction) using a visual analog scale.ResultsThe mean MBF for Group 1 was higher than Group 2 (p = .044) but not that of Group 3 (p = .923). Additionally, Group 3 displayed a higher MBF than Group 2, although this difference was not statistically significant (p = .096). Concerning patient satisfaction, all study groups reported high levels of satisfaction across all satisfaction elements, and no significant differences were observed between the groups.ConclusionWithin the limitations of this study, it can be concluded that Group 1 gives comparable anticipated treatment outcomes as Group 3 concerning biting force and patient satisfaction. However, Group 2 gives comparable satisfaction results with biting force value within the normal range; thus, it might be used as a treatment option in a specific situation.
Structural Design of π–d Conjugated TMxB3N3S6 (x=2, 3) Monolayer Toward Electrocatalytic Ammonia Synthesis
Authors: Sun Yongxiu , Shi Wenwu , Huang Aijian , Sun Mengxuan , Tu Renyong , Li Zhijie , Wang Zhiguo 
Published: September 2023

AbstractSingle–atom catalysts (SACs) have attracted wide attention to be acted as potential electrocatalysts for nitrogen reduction reaction (NRR). However, the coordination environment of the single transition metal (TM) atoms is essential to the catalytic activity for NRR. Herein, we proposed four types of 3‐, 4‐coordinated and π–d conjugated TMxB3N3S6 (x=2, 3, TM=Ti, V, Cr, Mn, Fe, Zr, Nb, Mo, Tc, Ru, Hf, Ta, W, Re and Os) monolayers for SACs. Based on density functional theory (DFT) calculations, I‐TM2B3N3S6 and III‐TM3B3N3S6 are the reasonable 3‐coordinated and 4‐coordinated structures screening by structure stable optimizations, respectively. Next, the structural configurations, electronic properties and catalytic performances of 30 kinds of the 3‐coordinated I‐TM2B3N3S6 and 4‐coordinated III‐TM3B3N3S6 monolayers with different single transition metal atoms were systematically investigated. The results reveal that B3N3S6 ligand is an ideal support for TM atoms due to existence of strong TM‐S bonds. The 3‐coordinated I‐V2B3N3S6 is the best SAC with the low limiting potential (UL) of −0.01 V, excellent stability (Ef=−0.32 eV, Udiss=0.02 V) and remarkable selectivity characteristics. This work not only provides novel π–d conjugated SACs, but also gives theoretical insights into their catalytic activities and offers reference for experimental synthesis.
Targeting deubiquitinases for cancer therapy
Authors: Xue Qian , Tang Daolin , Chen Xin , Liu Jinbao 
Published: September 2023

AbstractThe ubiquitin‐proteasome system assumes a critical role in numerous cellular processes, and among its components, deubiquitinases (DUBs) have emerged as essential regulators. With roughly 100 DUBs encoded within the human genome, these enzymes can be categorized into two main types: cysteine protease DUBs and metalloproteinase DUBs, based on the catalytic mechanism of the active site. DUBs exert significant influence over specific substrates implicated in cancer progression, establishing them as closely associated with various malignancies, including breast carcinoma, prostate cancer, and chronic myeloid leukemia. Consequently, the targeted inhibition of DUBs presents an enticing therapeutic strategy for cancer treatment. Here, we delve into the functional roles of DUBs in different cancer types and provide a thorough overview of the anticancer properties exhibited by DUB inhibitors. This knowledge will propel the development and clinical application of DUB inhibitors, opening promising avenues for tumor treatment.
A systematic review of congestion control in internet of vehicles and vehicular ad hoc networks: Techniques, challenges, and open issues
Authors: Hemmati Atefeh , Zarei Mani , Rahmani Amir Masoud 
Published: September 2023

SummaryThe Internet of Vehicles (IoV) integrates various technologies to enable real‐time data exchange between vehicles, pedestrians, roadside units, unmanned aerial vehicles, road‐added things, and so forth. IoV is an improved internet‐enabled vehicular ad hoc network (VANET), which is similarly affected by data traffic aggravated by time‐variant network density and the network's topological and informational changes. A high density of simultaneous vehicular communication leads to channel saturation and data congestion, which leads to rapid increases in data loss, packet latency, and lower service quality. Due to the importance of real‐time data communications in high dynamic networks, we used the systematic literature review (SLR) approach to identify 54 articles up to May 2023 to discuss the ways to deal with data traffic congestion in VANETs and IoV networks as well as existing and upcoming issues in this area.
Ten‐m3 plays a role in the formation of thalamostriatal projections
Authors: Tran Heidi , Sawatari Atomu , Leamey Catherine A. 
Published: September 2023

AbstractThe importance of the thalamostriatal pathway for a myriad of brain functions is becoming increasingly apparent. Little is known about the formation of this pathway in mice. Further, while Ten‐m3, a member of the Ten‐m/teneurin/Odz family, is implicated in the proper wiring of mature thalamostriatal projections, its developmental time course is unknown. Here, we describe the normal development of thalamostriatal projections arising from the parafascicular nucleus (PFN) and show a role for Ten‐m3 in its formation. Ten‐m3 is expressed in both the PFN and the striatum by embryonic day 17 (E17). By postnatal day 3 (P3), it had a patchy appearance in the striatum, overlaid on a high dorsal–low ventral expression gradient in both structures. In wild‐type mice, axons from the PFN begin to innervate the striatum by E17. By P3, terminals had ramified but were not confined to any striatal subregion. By P7, the axons had begun to avoid striosomes. The first indication of clustering of thalamic terminals within the striatal matrix was also seen at this time point. The compartmental targeting and clustering of PFN projections became more apparent by P10. Analysis of Ten‐m3 knockout mice showed that while the early developmental progression of the thalamostriatal pathway is conserved, by P10 differences emerged, with a loss of topographic precision and the absence of terminal clustering. No evidence of the involvement of EphA7 downstream of Ten‐m3 was found. Overall, our results suggest that Ten‐m3 plays a role in the consolidation and refinement of thalamic axons to a specific subregion of the striatal matrix.
A method for deriving the state space equations for degenerate linear time invariant circuits
Authors: Naseh Sasan 
Published: September 2023

AbstractA procedure for writing the state space equations for linear time invariant circuits is proposed. With this method the state equations for both degenerate and nondegenerate circuits can be derived in a systematic and unified manner. Capacitors' voltages and inductors' currents are chosen as state variables. First all the capacitors and inductors are replaced with voltage and current sources, respectively, and the modified nodal analysis is applied to this new circuit. By inspecting the system of equations obtained in this way and identifying the dependent equations among them, it is possible to detect any degeneracy, that is, dependency among the capacitors' voltages and inductors' currents, and subsequently refine the list of state variables. No knowledge of the circuits' graph is required and only its netlist description is needed in order to derive the equations, which makes it suitable for implementation as a computer program. Several examples are presented in which application of the method is demonstrated.
Sustainable per‐ and polyfluoroalkyl substances contaminated soil remediation: Evaluating the potential of thermal desorption
Authors: Rassaei Farzad 
Published: September 2023

AbstractPer‐ and polyfluoroalkyl substances (PFASs) have been extensively utilized in various industries. These artificial compounds pose significant environmental and health concerns as they exhibit persistence in soil over long periods and can migrate through soil and groundwater. One potential method for addressing PFASs toxicity is thermal desorption, although its efficacy in calcareous soil remains understudied. In this experimental investigation, we aimed to evaluate the effectiveness of thermal desorption in removing PFASs from two types of calcareous soil: spiked clay and sandy clay loam soil. PFASs were spiked into soil samples, which were subsequently freeze‐dried and homogenized. The samples underwent thermal desorption, followed by extraction and analysis of remaining PFASs concentrations using UPLC MS/MS. The study examined the impact of different temperatures, times, and soil types on PFASs removal. Results revealed that the removal fraction of PFASs increased with higher temperatures, although the specific effect varied depending on the soil type and the characteristics of the PFASs. Optimal PFASs removal occurred within the temperature range of 350 to 450°C, with a treatment time of 40 to 60 min. ANOVA analysis indicated a significant interaction between temperature and time, highlighting the influence of temperature on PFASs desorption. The correlation coefficient demonstrated a negative relationship between temperature and PFASs removal from the soil sample. This study successfully demonstrated the effectiveness of thermal desorption in removing PFASs from calcareous soils. The findings contribute to the development of effective strategies for mitigating the environmental and health risks associated with PFASs contamination in soil.
Boosting Copper Biocidal Activity by Silver Decoration and Few‐Layer Graphene in Coatings on Textile Fibers
Authors: Štular Danaja , de Velde Nigel Van , Drinčić Ana , Kogovšek Polona , Filipić Arijana , Fric Katja , Simončič Barbara , Tomšič Brigita , Chouhan Raghuraj S. , Bohm Sivasambu , Kr. Verma Suresh , Panda Pritam Kumar , Jerman Ivan 
Published: September 2023

AbstractThe outbreak of the Coronavirus disease 2019 (COVID‐19) pandemic has highlighted the importance of developing antiviral surface coatings that are capable of repelling pathogens and neutralizing them through self‐sanitizing properties. In this study, a novel coating design based on few‐layer graphene (FLG) is proposed and silver‐decorated micro copper flakes (CuMF) that exhibit both antibacterial and antiviral properties. The role of sacrificial anode surfaces and intrinsic graphene defects in enhancing the release of metal ions from CuMF embedded in water‐based binders is investigated. In silico analysis is conducted to better understand the molecular interactions of pathogen‐repelling species with bacterial or bacteriophage proteins. The results show that the optimal amount of CuMF/FLG in the coating leads to a significant reduction in bacterial growth, with reductions of 3.17 and 9.81 log for Staphylococcus aureus and Escherichia coli, respectively. The same coating also showed high antiviral efficacy, reducing bacteriophage phi6 by 5.53 log. The antiviral efficiency of the coating is find to be doubled compared to either micro copper flakes or few‐layer graphene alone. This novel coating design is versatile and can be applied to various substrates, such as personal protective clothing and face masks, to provide biocidal activity against both bacterial and viral pathogens.