bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association of paraoxonase I gene polymorphisms Q192R (rs662) and L55M (rs854560) and its activity with metabolic syndrome components in fars ethnic group
Authors: Marjani Abdoljalal , Poursharifi Nahid , Hashemi Mohammad Mostakhdem , Sajedi Atefe , Tatari Mahin 
Published: February 2023

Abstract

Objectives
Metabolic syndrome (MetS) may cause premature development of some diseases. PON1 genes may be involved in the pathogenesis of MetS. The aim of study was to evaluate the association between Q192R and L55M gene polymorphisms and its enzyme activity with the MetS components in subjects with and without MetS.

Methods
Polymerase Chain Reaction and Restriction Fragment Length Polymorphism analysis were performed to determine polymorphisms of the paraoxonase1 gene in subjects with and without metabolic syndrome. Biochemical parameters were measured by spectrophotometer.

Results
The MM, LM, and LL genotype frequencies of the PON1 L55M polymorphism were 10.5, 43.4, and 46.1%, and 22.4, 46.6, and 31% and; the QQ, QR, and RR genotype frequencies of the PON1 Q192R polymorphism were 55.4, 38.6 and 6%; and 56.5, 34.8 and 8.7% in subjects with and without MetS, respectively. The L and M allele frequencies were 68 and 53%; and 32 and 47% for PON1 L55M in subjects with and without MetS, respectively. The Q and R allele frequencies for PON1 Q192R were 74 and 26% in both groups. There were significant differences in HDL-cholesterol level and PON1 activity in the genotypes QQ, QR, and RR of the PON1 Q192R polymorphism in subjects with MetS.

Conclusions
The PON1 Q192R genotypes had only effected on PON1 activity and HDL-cholesterol level in subjects with MetS. Different genotypes of the PON1 Q192R seem to be important candidates to make the subjects susceptible to MetS in the Fars ethnic group.
Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
Authors: Büyükavcı Mehmet Akif , Dundar Ismail 
Published: February 2023

Abstract

Objectives
Congenital hypothyroidism (CH) is still one of the most common causes of preventable cognitive impairment in children, and its early detection and treatment prevent irreversible neurodevelopmental delay. Depending on the underlying cause, cases with CH may be transient or permanent. This study aimed to compare the developmental evaluation results of transient and permanent CH patients and to reveal any differences.

Methods
A total of 118 patients with CH, who were followed up jointly in pediatric endocrinology and developmental pediatrics clinics, were included. The patients’ progress was evaluated per the International Guide for Monitoring Child Development (GMCD).

Results
Of the cases, 52 (44.1%) were female, and 66 (55.9%) were male. While 20 (16.9%) cases were diagnosed with permanent CH, 98 (83.1%) were diagnosed with transient CH. According to the results of the developmental evaluation made with GMCD, the development of 101 (85.6%) children was compatible with their age, while 17 (14.4%) children had delays in at least one developmental area. All 17 patients had a delay in expressive language. Developmental delay was detected in 13 (13.3%) of those with transient CH and 4 (20%) with permanent CH.

Conclusions
There is difficulty in expressive language in all cases of CH with developmental delay. No significant difference was found between the developmental evaluations of permanent and transient CH cases. The results revealed the importance of developmental follow-up, early diagnosis and interventions in those children. GMCD is thought to be an important guide to help monitoring the development of patients with CH.
Norm Externalisation and the Evolution of Cooperation
Authors: Valković Martina 
Published: February 2023

Abstract
In a recent article, Kyle Stanford gives an account of what he terms “externalisation”, understood as our tendency to objectify or externalise moral demands and obligations. According to Stanford, externalisation is a distinctive feature of our moral psychology which is adaptive since it enables and preserves cooperation. I claim that the main issue with this account is that it assumes an overly psychological and individualist, inward-to-outward looking perspective. I advocate taking an alternative perspective that turns the spotlight to social practices and the social reality they create. I show how, seen in this light, norm externalisation becomes a side-effect instead of an adaptation deserving of a special explanation.
The crystal structure of hexalithium decavanadate hexadecahydrate, H32Li6O44V10
Authors: Liu Wanxing , Wang Baolei , Yang Yanbing , Liu Dong , Dai Yifan , Zhang Meiyu 
Published: February 2023

Abstract
H32Li6O44V10, orthorhombic, Pnnm (no. 58), a = 10.3463(7) Å, b = 17.6637(14) Å, c = 9.2458(8) Å, V = 1689.7(2) Å3, Z = 2, Rgt
(F) = 0.0436, wR

ref
(F
2) = 0.1271, T = 293 K.
Mesh-independent multidimensional coupling of surface and subsurface water flow models
Authors: Novikov Konstantin 
Published: February 2023

Abstract
We present a new approach for multidimensional surface–subsurface flow coupling. The method does not require mesh-to-canal refinement or alignment and is based on numerical characteristics of the intersection of one-dimensional hydraulic object beds and the surface faces of the 3D tetrahedral mesh. The method is validated using widely recognized tilted v-catchment with subsurface and Borden catchment benchmarks.
The new sea ice thermodynamics code for the INM RAS Earth System model: The design and comparison of one- and zero-dimensional approaches with the observational data
Authors: Petrov Sergey S. , Zyuzin Vladimir K. , Iakovlev Nikolay G. 
Published: February 2023

Abstract
This work is devoted to the comparison of one- (1-D) and zero-dimensional (0-D) models of sea ice thermodynamics. 1-D thermodynamics solvers imply the solution of the diffusion equation with penetrating radiation in the moving domain (moving boundary problem), while 0-D implementations neglect the heat capacity of ice and penetrating radiation, that leads to a linear temperature profile by the construction. So far, some climate models use 0-D implementation of thermodynamics in a block of sea ice, while other models use 1-D implementation with a small number of nodes. In this work we present our fully implicit 0-D and 1-D version of snow–ice thermodynamics, which relieves the model of Courant-type time step constraints. Implicitness is achieved by the relaxation method for nonlinear heat capacity and thermal conductivity coefficients with simultaneous search for the temperature that satisfies the boundary conditions. We introduce the experiment with analytical forcing to compare evolution of temperature profiles. This model experiment shows that 0-D model underestimates ice thickness and overestimates the amplitude of temperature profile variation compared to 1-D solution. Despite the large differences in thickness and internal temperatures, the surface temperatures are very close. The models were also validated on the data of the SHEBA field experiment. According to comparison with observation data, the 0-D model predicts ice thickness and spatiotemporal temperature distribution much worse compared to 1-D model, but the amplitude of error in surface temperature is slightly greater for 0-D code. It can be concluded that 0-D model of sea ice thermodynamics is a good tool for predicting surface temperature, but it gives a large error in thickness and temperature distribution.
Aging Resistance of Bitumen Modifiers: A Comprehensive Review
Authors: Abraham Sarah Mariam , Verma Muskan , Kakade Vijay 
Published: February 2023

AbstractThe deterioration of physical and mechanical properties of bituminous materials that are attributable to the aging of bitumen is one of the major causes of reduction in service life of flexible pavements. Thermal-oxidation and photo-oxidation aging are the two major types of aging of bitumen. Heat and oxygen cause thermal-oxidative aging, whereas ultraviolet irradiation and oxygen causes ultraviolet photo-oxidative aging of bitumen. Aging of binder leads to significant changes in the chemical composition of bitumen resulting in reduction of cracking resistance of bituminous mixes because of hardening of bitumen. So, it is quintessential to reduce the rate of hardening of bitumen induced by aging for prevention of premature failure of flexible pavements. The type of bitumen used for production of bituminous mixes have a significant effect on aging resistance of bitumen. The bitumen can be modified by using different types of modifiers such as antioxidants, bio-oils, nanomaterials, polymers, rubber, and ultraviolet absorbers. In addition to this, the modifiers such as fillers, warm mix additives, and rejuvenators also affect the aging resistance of bitumen. However, the effectiveness of these modifiers in preventing the hardening of bitumen because of aging varies with type of aging. The modifiers that exhibit improvement in thermal-oxidative aging resistance of bitumen are found to be less effective in improvement in photo-oxidative aging resistance and vice-versa. So, it is imperative to understand the effectiveness of different types of bitumen modifiers for the prevention of thermal-oxidative and photo-oxidative aging of bitumen. This review documents the resistance of different types of modifiers to thermal-oxidative and photo-oxidative aging. Finally, the scope for future work based on the critical gaps identified from existing works is also provided to assist further research.
METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53‐wild‐type cells
Authors: Hou Yichao , Zhang Xintian , Yao Han , Hou Lidan , Zhang Qingwei , Tao Enwei , Zhu Xiaoqiang , Jiang Shanshan , Ren Yimeng , Hong Xialu , Lu Shiyuan , Leng Xiaoxu , Xie Yile , Gao Yaqi , Liang Yu , Zhong Ting , Long Bohan , Fang Jing‐Yuan , Meng Xiangjun 
Published: February 2023

AbstractThe frequency of p53 mutations in colorectal cancer (CRC) is approximately 40–50%. A variety of therapies are being developed to target tumors expressing mutant p53. However, potential therapeutic targets for CRC expressing wild‐type p53 are rare. In this study, we show that METTL14 is transcriptionally activated by wild‐type p53 and suppresses tumor growth only in p53‐wild‐type (p53‐WT) CRC cells. METTL14 deletion promotes both AOM/DSS and AOM‐induced CRC growth in mouse models with the intestinal epithelial cell‐specific knockout of METTL14. Additionally, METTL14 restrains aerobic glycolysis in p53‐WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m6A‐YTHDF2‐dependent pri‐miR‐6769b/pri‐miR‐499a processing. Biosynthetic mature miR‐6769b‐3p and miR‐499a‐3p decrease SLC2A3 and PGAM1 levels, respectively, and suppress malignant phenotypes. Clinically, METTL14 only acts as a beneficial prognosis factor for the overall survival of p53‐WT CRC patients. These results uncover a new mechanism for METTL14 inactivation in tumors and, most importantly, reveal that the activation of METTL14 is a critical mechanism for p53‐dependent cancer growth inhibition, which could be targeted for therapy in p53‐WT CRC.
Effect of Population Density and Altitude on COVID-19 : A Spatial Pattern
Authors: Cahyati Widya Hary , Purwoko Sidiq , Farida Eko , Khairunnisa Marizka , Asturiningtyas Ika Puspita , Ashar Hadi , Puspitasari Candra 
Published: February 2023

The Covid-19 pandemic that has been going on since March 2020 has spread rapidly, with high mortality In Indonesia. Central Java, Covid-19 remains a disease with a Case Fatality Rate (CFR) of 4.4% and is above Indonesia’s CFR of 3.0%. In Magelang itself, positive cases of Covid-19 in 2020 reached 4418 and were among the top 3 cases in Central Java Province. This study’s purpose was to spatially describe the distribution of new cases of Covid-19 in terms of population density and elevation of the sub-district area in Magelang. The type of research is descriptive quantitative with ecological studies using a spatial approach. The results showed that the distribution of new cases of Covid-19 has a unique pattern in mapping based on population density and altitude. Some of the new distribution cases showed a distribution pattern following the regional elevation and almost entirely following the pattern of population density. The increase of Covid-19 tends to be higher in areas with high-density populations and low-altitude regions. This study concludes that the distribution pattern of new Covid-19 cases is influenced by population density and the area’s height during the peak period of new Covid-19 cases in 2020 at Magelang.
Effect of COVID-19 PPKM on BMI, Glucose Levels, and HbA1c in Patients DM Type 2 di Demak Regency
Authors: Kamisih Kamisih , Azam Mahalul , Yuniastuti Ari 
Published: February 2023

Implementing COVID-19 Community Activity Restrictions (Pemberlakuan Pembatasan Kegiatan Masyarakat/PPKM) affects community activities, including type-2 Diabetes mellitus patients in Demak Regency. BMI and HbA1c are risk factors for increased blood glucose levels of DM type 2. This research aims to determine the impact of corvid-19 PPKM against BMI, Glucose Levels, and HbA1c in Type 2 DM Patients in Demak Regency. This study used secondary data from the Chronic Disease Management Program (PROLANIS) in three health centers (Pusat Kesehatan Masyarakat/Puskesmas) in Demak Regency. Which was grouped into measurements before PPKM (October 2019 and February 2020), the PPKM period (August 2021), and the end of PPKM (March 2022). The complete variables were incorporated into the final analysis. A total of 164 respondents were spread across in Wonosalam 1 (n=64), Bonang 2 (n=49), and Wedung 1 (n=51). The results of the Analysis of Friedman and the Wilcoxon post hoc showed that there was an influence of COVID-19 PPKM on Glucose Levels (p= 0.000) and HbA1c (p = 0.000). There was no influence on BMI (p = 0.108) in Dm Type 2 patients in Demak Regency, meaning on the variable levels of FBS and HbA1c, there are at least two different measurements in October 2019, February 2020, August 2021, and March 2022 measurements. Special attention is needed in DM patients to control changes in BMI, Glucose levels, and HbA1c during the implementation of COVID-19 PPKM.
Are integrins and ligands correlated at pig placental interface during pregnancy?
Authors: Carolina Velez , Mariangeles Clauzure , Delia Williamson , Monica Garcia , Mirta Koncurat , Claudio Barbeito 
Published: February 2023

In the present work, we emphasize the studies about integrins and their receptors in pig placental interface at different times of gestation. Uterine placental interface (n = 24) of 17, 30, 60 and 70 days of gestation (dg) and non-pregnant uterus (n = 4) of crossbred sows were used. The presence of αvβ3 (ITGAV (integrin subunit alpha V) ITGB3 (integrin subunit beta 3)) and α5β1 (ITGA5 (integrin subunit alpha V) ITGB3 (integrin subunit beta 3)) integrins, and their ligands fibronectin (FN) and osteopontin (OPN/ SPP1), was detected by immunohistochemistry, and the immunolabeled area percentage (IAP) and the optical density (OD) were determined. The integrins and its ligands analyzed have presented peaks of expression in early and mid-gestation, both in IAP and in the OD area, decreasing at 70 dg. These temporal changes showed us that the molecules studied in this work participate in embryo/feto–maternal attachment, variably. Besides, we found a significant correlation both in the intensity and in the extension of immunostaining for trophoblastic FN and endometrial αvβ3, and trophoblastic OPN and endometrial α5β1, throughout the entire pig pregnancy. At late gestation, there is notable placental remodeling with subsequent removal or renewal of folds at the uterine–placental interface that results in the loss of focal adhesions. The decrease of the expression of some integrins and their ligands in late gestation, particularly at 70 dg, would demonstrate that there would be other adhesion molecules and other ligands that could be participating in the establishment of the maternal–fetal interface.

Lay summary
To carry a successful pregnancy, the formation of the placenta in pigs depends on adhesion molecules. Some of these molecules called integrins bind to other molecules such as fibronectin (FN) and osteopontin (OPN/SPP1). The variation in those molecule amounts during gestation would indicate which molecule is participating and what role it plays in pregnancy. We worked with pig placentas of early, mid- and late- gestation and non-pregnant uteruses. αvβ3 (ITGAV (integrin subunit alpha V) ITGB3 (integrin subunit beta 3)) and α5β1 (ITGA5 (integrin subunit alpha 5) ITGB1 (integrin subunit beta 1)) integrins, FN and OPN were found until mid-gestation but not at late gestation, suggesting that other types of molecules have a role in the last period of gestation.
The psychological impact of COVID-19 lockdown on the wellbeing, learning efficacy and sleeping behaviors of Romanian medical students
Authors: Burlacu Codrin-Constantin , Chelaru Vlad-Florin , Drugan Tudor Cătălin , Bădulescu Andrei-Vlad 
Published: February 2023

Background and aims. The COVID-19 lockdowns are reported to have negatively influenced the wellbeing and learning efficacy of students. In this context, we analyzed the psychological impact of the COVID-19 quarantine on healthcare students, a subpopulation experiencing high stress levels.
Methods. Our survey-based, cross-sectional study assessed wellbeing indicators, lifestyle and learning behaviors before and during the quarantine for 388 Romanian healthcare students.
Results. Our findings included the increase in phone and social media use, at the expense of formal and independent study time; deteriorations in mood, self-organization capacity and learning efficacy, and increased procrastination behaviors. Unexpectedly, our study identified an improvement in sleep quality and duration. The increase in social media use was less severe among rural students. We identified correlations between study time, online activities (including social media), wellbeing indicators and procrastination.
Conclusion. Our study draws attention to quarantine-induced deteriorations of wellbeing and learning capacity in an important category of students.
Міжнародний досвід управління сферою освіти в умовах глобальних викликів
Authors: Сайферс Анастасія 
Published: February 2023

Автор статті розкриває актуальну тему управління сферою освіти в умовах глобальних викликів на основі вивчення та узагальнення позитивного міжнародного досвіду. На думку науковця фінансові та соціально-політичні кризи, стихійні лиха та війни, які домінують сьогодні у медійних заголовках, підкреслюють реальність того, що кризи більше не обмежені соціальними чи географічними кордонами. Ситуація, з якою нині стикається один регіон, швидше за все, завтра вплине на іншу громаду, країну чи континент. Окрім того, кризи не обмежуються одним сектором суспільства, наприклад, бізнес-сектором, вони перетікають в інші сектори, наприклад, державний і некомерційний.
Тому керівники освіти в громадах повинні слідкувати за кризовими тенденціями та гарантувати те, що їхні заклади освіти готові функціонувати в умовах глобальних викликів, тобто ендогенних, екзогенних, економічних криз. Розмір і розташування школи не захищають від криз. Керівники закладів освіти повинні визнати, що врегулювання кризових ситуацій ніколи не було бажанням, що минає, а є необхідним для відповідального управління освітою.
Реальність війни, пандемії довела, що навіть школи не є безпечними, підсилила потребу переглянути плани врегулювання кризових ситуацій, плани спілкування з внутрішніми та зовнішніми зацікавленими сторонами, стратегії забезпечення ефективного лідерства в культурі шкільної спільноти.
В статті акцентується увага, що інциденти в нинішньому суспільстві чітко обумовлюють потребу в кризовому плануванні. Випадки насильства привертають увагу засобів масової інформації, вони складають на тимчасово окупованих ворогом територіях великий відсоток криз, з якими стикаються шкільні округи. Однак існують й інші проблеми, пов’язані з фінансами, заходами підзвітності, змінами в навчальних програмах, шкільним кліматом або проблемами з персоналом, які також можуть стати кризою, якщо ситуація загострюється і заважає досягненню головної мети навчання учнів. Тож важливо знати як діяти в кризовій ситуації, чий досвід буде для вітчизняних управлінців корисним.
Фактори муніципального управління міським середовищем: температурний та вітровий комфорт
Authors: Бородін Євгеній , Миргородська Марія 
Published: February 2023

Цифрова трансформація змінює, окрім іншого, й ставлення до муніципального управління середовищем життя людині у різного типу поселеннях. Розглядається важливість міських відкритих просторів та їх ефективні параметри для формування муніципальної політики щодо створення комфортного міського середовища, зокрема сприяння підвищенню відвідуваності жителями міст відкритих просторів. В останні роки погана якість зовнішніх середовищ спричинила низький рівень відвідуваності людей у цих місцях і, як наслідок, збільшення різних проблем у житті людини. Одним із визначальних факторів, що впливають на якість навколишнього середовища, є забезпечення комфорту людини. Таких параметрів комфортного середовища багато і з поміж них зосереджено увагу на температурному та вітровому комфорті.
Метою цієї роботи є визначення можливостей органів муніципального управління щодо впливу на створення температурного та вітрового комфорту у містах. Розгляд цих факторів дозволить сформувати певні критерії для прийняття рішень щодо покращення комфортного середовища у містах та підвищення якості життя їх жителів.
Розглянуто різні аспекти створення вітрового та температурного комфорту на міських відкритих просторах, завдяки чому можливо повернути людей у міські простори соціального спілкування. Запропоновано деякі концептуальні рамки для проектування міських просторів з урахуванням забезпечення вітрового та температурного комфорту.
Висновки. Створення зони комфорту для жителів міст у відкритих просторах є викликом для дизайнерів та архітекторів, які займаються цим питанням. Але не менш важливо це і для керівників органів місцевого самоврядування, які визначають програми та плани розвитку міста. Потрібне розуміння важливої ролі відкритих просторів для розвитку комфортного середовища і розвитку міста. Успішний відкритий простір – це місце, що запрошує людей збиратися разом і взаємодіяти один з одним, підвищувати соціальну солідарність та місцеву ідентичність.