bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spin‐Orbit Readout Using Thin Films of Topological Insulator Sb2Te3 Deposited by Industrial Magnetron Sputtering
Authors: Teresi Salvatore , Sebe Nicolas , Patterson Jessy , Frottier Théo , Kandazoglou Aurélie , Noël Paul , Sgarro Paolo , Térébénec Damien , Bernier Nicolas , Hippert Françoise , Attané Jean‐Philippe , Vila Laurent , Noé Pierre , Cosset‐Chéneau Maxen 
Published: July 2023

AbstractDriving a spin‐logic circuit requires the production of a large output signal by spin‐charge interconversion in spin‐orbit readout devices. This should be possible by using topological insulators, which are known for their high spin‐charge interconversion efficiency. However, high‐quality topological insulators have so far only been obtained on a small scale, or with large scale deposition techniques that are not compatible with conventional industrial deposition processes. The nanopatterning and electrical spin injection into these materials have also proven difficult due to their fragile structure and low spin conductance. The fabrication of a spin‐orbit readout device from the topological insulator Sb2Te3 deposited by large‐scale industrial magnetron sputtering on SiO2 is presented. Despite a modification of the Sb2Te3 layer structural properties during the device nanofabrication, a sizeable output voltage is measured that can be unambiguously ascribed to a spin‐charge interconversion process. The results pave the way for the integration of layered van der Waals materials in spin‐logic devices.
Optical Characteristics of Stretchable Chiral Liquid Crystal Elastomer under Multiaxial Stretching
Authors: Kwon Chaehyun , Nam Seungmin , Han Sang Hyun , Choi Su Seok 
Published: July 2023

AbstractChiral liquid crystal elastomers (CLCEs) are soft photonic materials that exhibit both the photonic characteristics of nanoscale periodic helical structures and mechanical properties of rubber. Owing to its elasticity, the structural color of CLCEs can be tuned through mechanical deformations known as mechanochromism. Thus far, there is significant research attention to exploring the mechanochromism of CLCEs. However, most studies have only discussed the color shifting of CLCEs under uniaxial deformation. Therefore, the optical and chiral structural deformation behaviors of CLCEs under multiaxial stress are not well understood. This study investigates multiaxial (uniaxial, biaxial, and out‐of‐plane) stretching‐induced helical structure change and the resulting optical properties of CLCEs. The results confirm that uniaxial stretching leads to a loss of intrinsic circular polarization selectivity in CLCEs due to helix unwinding deformations, while biaxial and out‐of‐plane stretching maintain circular polarization.
A Miniaturized, Battery‐Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early
Authors: Garland Nate T. , Song Joseph W. , Ma Tengfei , Kim Yong Jae , Vázquez‐Guardado Abraham , Hashkavayi Ayemeh Bagheri , Ganeshan Sankalp Koduvayur , Sharma Nivesh , Ryu Hanjun , Lee Min‐Kyu , Sumpio Brandon , Jakus Margaret A. , Forsberg Viviane , Kaveti Rajaram , Sia Samuel K. , Veves Aristidis , Rogers John A. , Ameer Guillermo A. , Bandodkar Amay J. 
Published: July 2023

AbstractDiabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation and mortality, highlighting the critical need for their early detection. Recent demonstrations of wearable sensors enable real‐time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery‐free wound monitor that measures lactate in real‐time and seamlessly integrates with bandages for conformal attachment to the wound bed is introduced. Lactate is selected due to its multifaceted role in initiating healing. Studies in healthy and diabetic mice reveal distinct lactate profiles for normal and impaired healing wounds. A mathematical model based on the sensor data predicts wound closure rate within the first 3 days post‐injury with ≈76% accuracy, which increases to ≈83% when pH is included. These studies underscore the significance of monitoring biomarkers during the inflammation phase, which can offer several benefits, including short‐term use of wound monitors and their easy removal, resulting in lower risks of injury and infection at the wound site. Improvements in prediction accuracy can be achieved by designing mathematical models that build on multiple wound parameters such as pro‐inflammatory and metabolic markers. Achieving this goal will require designing multi‐analyte wound monitors.
All‐Electrospun, Water‐Resistant, Breathable, Wearable, and Stable Metal Halide Perovskite Engineered Electroactive Polymer Textiles for Flexible Piezoelectric Nanogenerator
Authors: Mondal Bidya , Sarkar Ranjini , Saini Dalip , Gupta Varun , Kundu Tarun Kumar , Mandal Dipankar 
Published: July 2023

AbstractHalide perovskite materials have recently received a lot of attention in the field of optoelectronic and energy harvesting applications regardless of their environmental instabilities. Herein, a three‐layer assembled wearable piezoelectric nanogenerator (PENG) is fabricated by continuous electrospinning process, where the middle layer is an active component, made of Cs3Bi2I9‐PVDF (PVDF‐CBI) nanofiber and outer layers are conducting (σ ≈ 2.2 S m−1) electrodes of PEDOT‐coated PVDF (PVDF‐PEDOT) nanofiber mats. The incorporation of perovskite Cs3Bi2I9fillers fully inducesβ‐phase (i.e., 100% of yield) in the PVDF matrix. Furthermore, the mechanism of electroactiveβ‐phase formation is analyzed by DFT studies. The PENG is able to generate superior open circuit voltage of ≈12 V, short circuit current of ≈7 µA, and power density of 3 µW cm−2. In addition, it demonstrates remarkable breathability (b ≈1.13 kg m−2d−1), flexibility, water‐resistive properties (water contact angle ≈138◦), and mechanoacoustic sensitivity (Sm≈5 V Pa−1), enabling the development of robust wearable devices that are efficient enough to monitor human physiological motions and simultaneously harvest the biomechanical energy. These findings ingeniously promote the acceptability of lead‐free metal halide perovskite and conducting polymer in wearable energy harvesting, self‐powered robotics, and health‐care devices applications.
Structure‐Crack Detection and Digital Twin Demonstration Based on Triboelectric Nanogenerator for Intelligent Maintenance
Authors: Xin Chuanfu , Xu Zifeng , Xie Xie , Guo Hengyu , Peng Yan , Li Zhongjie , Liu Lilan , Xie Shaorong 
Published: July 2023

AbstractThe accomplishment of condition monitoring and intelligent maintenance for cantilever structure‐based energy harvesting devices remains a challenge. Here, to tackle the problems, a novel cantilever‐structure freestanding triboelectric nanogenerator (CSF‐TENG) is proposed, which can capture ambient energy or transmit sensory information. First, with and without a crack in cantilevers, the simulations are carried out. According to simulation results, the maximum change ratios of natural frequency and amplitude are 1.1% and 2.2%, causing difficulties in identifying defects by these variations. Thus, based on Gramian angular field and convolutional neural network, a defect detection model is established to achieve the condition monitoring of the CSF‐TENG, and the experimental result manifests that the accuracy of the model is 99.2%. Besides, the relation between the deflection of cantilevers and the output voltages of the CSF‐TENG is first built, and then the defect identification digital twin system is successfully created. Consequently, the system is capable of duplicating the operation of the CSF‐TENG in a real environment, and displaying defect recognition results, so the intelligent maintenance of the CSF‐TENG can be realized.
Perovskite Solar Module: Promise and Challenges in Efficiency, Meta‐Stability, and Operational Lifetime
Authors: Le Thanh‐Hai , Driscoll Honora , Hou Cheng‐Hung , Montgomery Angelique , Li Wayne , Stein Joshua S. , Nie Wanyi 
Published: July 2023

AbstractPerovskite photovoltaics (PVs) are an emerging solar energy generation technology that is nearing commercialization. Despite the unprecedented progress in increasing power conversion efficiency (PCE) for perovskite solar cells (PSCs), up‐scaling lab‐made cells to solar modules remains a challenge. In this work, the recent progress of making perovskite mini‐modules is reviewed. In particular, a database summarizing the module size, performance, hysteresis, and operational lifetimes reported in the literature is built. After analyzing the performance losses from scaling PSCs to mini‐modules based on the data collected from the literature, the current key to high‐performance perovskite mini‐modules is found to be the coating method optimization. If the perovskite layer quality is well reserved, a >24% mini‐module efficiency is projected by only considering the losses from lateral resistivity and laser scribing area. Next, performance characteristics are explored including hysteresis and meta‐stable power outputs that must be overcome to correctly characterize perovskite modules. Finally, current challenges associated with the long‐term stability of perovskite modules are examined and the importance of such durability for commercialization is discussed. It is hoped that the findings in this review provide a bridge for the development of perovskite modules that will lead to commercialization in the near future.
A simulative deep learning model of SNP interactions on chromosome 19 for predicting Alzheimer's disease risk and rates of disease progression
Authors: Bae Jinhyeong , Logan Paige E. , Acri Dominic J. , Bharthur Apoorva , Nho Kwangsik , Saykin Andrew J. , Risacher Shannon L. , Nudelman Kelly , Polsinelli Angelina J. , Pentchev Valentin , Kim Jungsu , Hammers Dustin B. , Apostolova Liana G. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: July 2023

AbstractBACKGROUNDIdentifying genetic patterns that contribute to Alzheimer's disease (AD) is important not only for pre‐symptomatic risk assessment but also for building personalized therapeutic strategies.METHODSWe implemented a novel simulative deep learning model to chromosome 19 genetic data from the Alzheimer's Disease Neuroimaging Initiative and the Imaging and Genetic Biomarkers of Alzheimer's Disease datasets. The model quantified the contribution of each single nucleotide polymorphism (SNP) and their epistatic impact on the likelihood of AD using the occlusion method. The top 35 AD‐risk SNPs in chromosome 19 were identified, and their ability to predict the rate of AD progression was analyzed.RESULTSRs561311966 (APOC1) and rs2229918 (ERCC1/CD3EAP) were recognized as the most powerful factors influencing AD risk. The top 35 chromosome 19 AD‐risk SNPs were significant predictors of AD progression.DISCUSSIONThe model successfully estimated the contribution of AD‐risk SNPs that account for AD progression at the individual level. This can help in building preventive precision medicine.
Preparation of SiO2/Si3N4ws/PU reinforced coating and its reinforcement mechanism for SLS‐molded TPU materials
Authors: Zhang Cheng , Wu Wei , Hu Huanbo , Rui Zhengguo , Ye Junjian , Wang Zhengyi , Wang Yi , Shen Hui 
Published: July 2023

AbstractTo address the shortcomings of large porosity and insufficient mechanical properties of skeletonized Thermoplastic polyurethane (TPU) fabrications during the preparation of composite materials by selective laser sintering (SLS) technology. In this paper, SiO2@Si3N4ws‐GPTMS core‐shell structure filler was successfully prepared by first synthetically growing silicon dioxide (SiO2) nanospheres on the surface of silicon nitride whiskers (Si3N4ws) in situ by sol–gel method, and then modified with silane coupling agent Silane coupling agent (GPTMS). Then the filler was incorporated into the inner and outer surfaces of TPU skeletonized structural parts by vacuum dip coating using a water‐based polyurethane (PU) coating post‐treatment enhancement method, and the surface coating coating of TPU skeletonized structural parts was achieved by warming and curing. This composite filler coating structure greatly improved the mechanical properties of the SLS parts (tensile strength of 20.3 MPa and elongation at break of 338.9%, 163% higher tensile strength, 17.7% higher elongation at break, and 672% higher rebound dimension compared with the pure TPU sintered parts). In addition, the thermal stability of the SLS sintered parts was improved, which greatly enhanced the application of the sintered manufactured parts prepared by SLS technology in the field of rebound‐absorbing artificial wear.
The influence of redox modulation on hypoxic endothelial cell metabolic and proteomic profiles through a small thiol‐based compound tuning glutathione and thioredoxin systems
Authors: Bruschi Michela , Biancucci Federica , Masini Sofia , Piacente Francesco , Ligi Daniela , Bartoccini Francesca , Antonelli Antonella , Mannello Ferdinando , Bruzzone Santina , Menotta Michele , Fraternale Alessandra , Magnani Mauro 
Published: July 2023

AbstractReduction in oxygen levels is a key feature in the physiology of the bone marrow (BM) niche where hematopoiesis occurs. The BM niche is a highly vascularized tissue and endothelial cells (ECs) support and regulate blood cell formation from hematopoietic stem cells (HSCs). While in vivo studies are limited, ECs when cultured in vitro at low O2 (<5%), fail to support functional HSC maintenance due to oxidative environment. Therefore, changes in EC redox status induced by antioxidant molecules may lead to alterations in the cellular response to hypoxia likely favoring HSC self‐renewal. To evaluate the impact of redox regulation, HUVEC, exposed for 1, 6, and 24 h to 3% O2 were treated with N‐(N‐acetyl‐l‐cysteinyl)‐S‐acetylcysteamine (I‐152). Metabolomic analyses revealed that I‐152 increased glutathione levels and influenced the metabolic profiles interconnected with the glutathione system and the redox couples NAD(P)+/NAD(P)H. mRNA analysis showed a lowered gene expression of HIF‐1α and VEGF following I‐152 treatment whereas TRX1 and 2 were stimulated. Accordingly, the proteomic study revealed the redox‐dependent upregulation of thioredoxin and peroxiredoxins that, together with the glutathione system, are the main regulators of intracellular ROS. Indeed, a time‐dependent ROS production under hypoxia and a quenching effect of the molecule were evidenced. At the secretome level, the molecule downregulated IL‐6, MCP‐1, and PDGF‐bb. These results suggest that redox modulation by I‐152 reduces oxidative stress and ROS level in hypoxic ECs and may be a strategy to fine‐tune the environment of an in vitro BM niche able to support functional HSC maintenance.
Predictive and prognostic role of early apolipoprotein A‐I alteration in recurrent or metastatic nasopharyngeal carcinoma patients treated with anti‐PD‐1 therapy
Authors: Xiao Bi Jing , Sima Xiao Xian , Chen Gang , Gulizeba Haimiti , Zhou Ting , Huang Yan 
Published: July 2023

AbstractBackgroundThe primary objective of this study was to evaluate the predictive and prognostic value of serum lipids in recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) patients received anti‐PD‐1 therapy.Materials and MethodsPatients treated with anti‐PD‐1 therapy (monotherapy or combined with chemotherapy) from two clinical trials (CAPTAIN and CAPTAIN‐1st study) were included. Serum lipids were measured at baseline and after two cycles of treatment. We examined the impact of both baseline and post‐treatment lipid levels on objective response rate (ORR), progression‐free survival (PFS), and duration of response (DOR).ResultsOf 106 patients, 89 patients (84%) were male. The patients' median age was 49 years. An early elevated (after two cycles of treatment) cholesterol (CHO), low‐density lipoprotein cholesterol (LDL‐C), apolipoprotein A‐I (ApoA‐I), and apolipoprotein B (ApoB) were significantly associated with better ORR. Moreover, early elevated CHO, LDL‐C, and ApoA‐I were also positively correlated with DOR and PFS. Further multivariate analysis showed that only early change in ApoA‐I could independently predict PFS (HR, 2.27; 95% CI, 1.11–4.61; p = 0.034). The median PFS for patients with early elevated and reduced ApoA‐I was 11.43 and 1.89 months, respectively. However, baseline lipids levels do not play a significant role in the prognosis and prediction of patients with anti‐PD‐1 treatment.ConclusionCollectively, an early elevation in ApoA‐I was correlated with better outcomes for anti‐PD‐1 therapy in patients with R/M NPC, suggesting that clinicians should consider the early alteration of ApoA‐I as a useful marker in treating R/M NPC patients with anti‐PD‐1.
Design, Synthesis, and Docking Study of Quinine‐9‐Triazolyl Conjugates
Authors: Bose Priyanka , Singh Mala , Singh Anoop S. , Jaiswal Manoj K. , Tiwari Vinod K. 
Published: July 2023

AbstractTo develop a better chemotherapeutically potential candidate for lung cancer treatment and cure with repurposed motifs, quinine has been linked with biocompatible CuAAC‐inspired regioselective 1,2,3‐triazole linker and a series of ten novel 1,2,3‐triazolyl‐9‐quinine conjugates have been developed by utilizing click conjugation of glycosyl ether alkynes with 9‐epi‐9‐azido‐9‐deoxy‐quinine under standard click conditions. In parallel, the docking study indicated that the resulting conjugates have an overall appreciable interaction with ALK‐5 macromolecules. Moreover, the mannose‐triazolyl conjugate exhibited the highest binding interactions of −7.6 kcal/mol with H‐bond interaction with the targeted macromolecular system and indicate the hope for future trials for anti‐lung cancer candidates.
Four New Flavonoid C‐Glycosides Isolated from Achyranthes aspera and Their Nitric Oxide Production Inhibitory Activities
Authors: Tuyet Lan Hoang Thi , Mai Nguyen Thi , Mai Anh Bui Thi , Dung Duong Thi , Van Kiem Phan , Huu Tai Bui 
Published: July 2023

AbstractA chemical study of the methanol extract of the aerial parts of Achyranthes aspera led to the isolation of four new flavonoid C‐glycosides (1–4) along with eight known analogs (5–12). Their structures were elucidated by a combination of spectroscopic data analysis, HR‐ESI‐MS, 1D and 2D NMR spectra. All the isolates were evaluated their NO production inhibitory activity in LPS‐activated RAW264.7 cells. Compounds 2, 4, and 8–11 showed significant inhibition with IC50 values ranging from 25.06 to 45.25 μM, compared to that of the positive control compound, L‐NMMA, IC50 value of 32.24 μM, whereas the remaining compounds were weak inhibitory activity with IC50 values over 100 μM. This is the first report of 7 from Amaranthaceae family, and 11 from the genus Achyranthes.
Secondary cardiac amyloidosis in a patient with mixed connective tissue disease: A case report
Authors: Khanal Ujjwal Prakash , Ghimire Prinska , Shahi Tejash , Dhakal Tulsi Ram , Jha Saket 
Published: July 2023

AbstractWe report the case of a 62‐year‐old man who presented with shortness of breath, cough, bilateral lower limbs' swelling, and blackish discoloration of multiple fingertips over the past 2 months. Anti‐Ribonucleoprotein antibodies were found to be present, and gadolinium‐based cardiac MRI showed non‐vascular subendocardial enhancement with diffuse symmetrical thickening of the left ventricular wall. A diagnosis of Mixed connective tissue disease with secondary cardiac amyloidosis was thus made, and the patient was successfully managed with intravenous cyclophosphamide, corticosteroids, and other supportive measures. Although extremely rare, this case shows that secondary cardiac amyloidosis should be considered while managing patients with MCTD.
High‐Temperature Air Synthesis: A Facile Approach to Nitrogen‐Doped, Metal‐Free Carbon Electrocatalysts
Authors: Etesami Mohammad , Khezri Ramin , Rezaei Motlagh Shiva , Gopalakrishnan Mohan , Thanh Nguyen Mai , Yonezawa Tetsu , Wannapaiboon Suttipong , Nootong Kasidit , Somwangthanaroj Anongnat , Kheawhom Soorathep 
Published: July 2023

AbstractThis study presents a novel, straightforward method for synthesizing hierarchical nitrogen‐doped carbon structures, positioning metal‐free, carbon‐based materials as potential substitutes in electrochemical reactions such as oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER). The unique method involves a single‐step pyrolysis process in an air atmosphere, eliminating the need for an inert atmosphere and pre‐treatment procedures. It enables simultaneous self‐templating and heteroatom doping, resulting in oxygen‐rich functional groups embedded in the nitrogen‐doped carbon structure. We also crafted a carbon structure without heteroatom doping, comparing its electrochemical performance in ORR and HER. Our findings indicate that carbon catalysts pyrolyzed at higher temperatures have more pyridinic N, functional groups, and active sites‐ factors conducive to electrochemical reactions. We tested the air‐synthesized electrocatalysts for ORR in alkaline electrolyte and employed the optimized nitrogen‐doped carbon catalyst, pyrolyzed at 700 °C in an air atmosphere, as cathode material in a zinc‐air battery. This catalyst demonstrated ORR performance comparable to the commercial Pt/C catalyst and showed minimal overpotential in acidic HER. Our research establishes a pioneering technique for synthesizing porous, metal‐free, nitrogen‐doped carbon materials, paving the way for potential energy applications.
Prediction of Water‐Methanol Mixture Properties by Molecular Dynamics Simulation
Authors: Moradi Hojatollah , Azizpour Hedayat , Keynejad Kamran , Ghorbani Nia Reyhane , Esmaeili Amin 
Published: July 2023

AbstractThe water‐methanol mixture density at 293.15–303.15 K and atmospheric pressure was predicted by using molecular dynamics (MD) simulation and empirical data. To compute van der Waals and electrostatic interactions, the Ewald summation and atom‐based approaches were used. Then, Jouyban‐Acree (J‐A) and density correlation methods for two‐component mixtures were applied for MD simulation results at various temperatures and methanol mole fractions. The COMPASS force field was the best to envisage the mixture density. The average absolute relative deviation (AARD) for J‐A and density correlation models was estimated at 0.12 and 0.15 %, respectively. Based on the MD simulation and experimental data, the AARD for the water‐methanol mixture density at 293.15, 298.15, and 303.15 K was 4.25, 4.37, and 4.8 %, respectively.
Effect of Mg/Al Oxides Supports on CaO Sorbents Prepared by Wet‐Mixing Synthesis for CO2 Capture
Authors: Qi Xiaolei , Luo Cong , Wu Huizhe , Wang Guang , Luo Tong 
Published: July 2023

AbstractCalcium looping is one of the effective methods for post‐combustion CO2 capture. A key issue is choosing the appropriate supports to synthesize effective calcium‐based sorbents. In this study, calcium looping sorbents incorporated with MgO, Ca3Al2O6, and MgAl2O4 supports were prepared by wet‐mixing synthesis. Characterizations were made to determine the cyclic CO2 capture capacity, crystalline structure, porosity, and morphological changes of the sorbents over multiple cycles. The results showed that, at the mass ratio of CaO to support oxides of 7:3, the MgAl2O4 mixed support showed better CO2 capture performance than the MgO and Ca3Al2O6 supports. Moreover, the sorbent showed a porous and fluffy microstructure with a high specific surface area, making it a suitable candidate for cyclic CO2 capture.