bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving cross‐sectoral policy integration in multilevel structures—Loosely coupled coordination of “energy transition” in the German “Bundesrat”
Authors: Behnke Nathalie , Hegele Yvonne 
Published: April 2023

AbstractThe big policy challenges of our times are complex problems cutting across policy sectors and levels of government. To answer the question how cross‐sectoral policy coordination in multilevel structures can be achieved, we argue in line with policy integration and multilevel governance scholarship that “loosely coupled” institutions create the interdependency necessary to secure complex coordination. This argument is substantiated empirically by investigating coordination of energy transition in the German Bundesrat. Expectations are derived on how loosely coupled institutions promote coordination. They are tested using a mix of empirical data. It can be shown that loosely coupled institutions indeed enable coordination by linking powers across multiple dimensions, creating incentives for cross‐sectoral communication, using personal ties in negotiations to bridge different institutional backgrounds, and sequencing the decision process to allow strategic shifts between coordination dimensions. Those mechanisms may not guarantee the best possible result, but they provide a satisfactory solution at least.
Sustainable soil management in the United Kingdom: A survey of current practices and how they relate to the principles of regenerative agriculture
Authors: Jaworski Coline C. , Krzywoszynska Anna , Leake Jonathan R. , Dicks Lynn V. 
Published: April 2023

AbstractSustainable soil management is essential to prevent agricultural soil degradation and maintain food production and core soil‐based ecosystem services. Regenerative agriculture, one approach to sustainable soil management, is rapidly gaining traction in UK farming and policy. However, it is unclear what farmers themselves consider to be sustainable soil management practices, and how these relate to the principles of regenerative agriculture. Further, there is little insight into how sustainable soil management is currently promoted in agricultural knowledge and innovation services (AKIS). To address these knowledge gaps, we undertook the first national‐scale survey of sustainable soil management practices in the United Kingdom and complemented it with targeted interviews. We found high levels of awareness (>60%) and uptake (>30%) of most sustainable soil management practices among mixed and arable farmers. Importantly, 92% of respondents considered themselves to be practising sustainable soil management. However, our analysis shows that farmers combine practices in different ways. Not all these combinations correspond to the full set of regenerative agriculture principles of reduced soil disturbance, soil cover and crop diversity. To better understand the relationship between existing sustainable soil management practices in the United Kingdom and regenerative agriculture principles, we derive a “regenerative agriculture score” by allocating individual practices among the principles of regenerative agriculture. Farmers who self‐report that they are managing soil sustainably tend to score more highly across all five principles. We further find that sustainable soil management messaging is fragmented and that few AKIS networks have sustainable soil management as their primary concern. Overall, our study finds that there are multiple understandings of sustainable soil management among UK farmers and land managers and that they do not correspond to regenerative agriculture principles in a straightforward way. This diversity and variety in sustainable soil management needs to be taken into account in future policy and research.
Serum level of apoptosis inhibitor of macrophage in dogs with histiocytic sarcoma and its association with the disease
Authors: Uchida Mona , Matsumiya Yuki , Tsuboi Masaya , Uchida Kazuyuki , Nakagawa Takayuki , Fujii Wataru , Kobayashi Tetsuya , Tsujimoto Hajime , Ohmi Aki , Tomiyasu Hirotaka , Motegi Tomoki , Maeda Shingo , Momoi Yasuyuki , Yonezawa Tomohiro 
Published: April 2023

AbstractHistiocytic sarcoma (HS) is a rare neoplasm of macrophages or dendritic cells with a poor prognosis in dogs. As the apoptosis inhibitor of macrophage (AIM) is characteristically expressed in canine macrophages, we hypothesised that AIM is involved in the development or progression of HS in dogs. In this study, AIM expression in the tumour region and serum AIM levels in dogs with HS was assessed. Additionally, the effects of AIM overexpression on HS cell viability were investigated using a HS cell line that was selected from five validated HS cell lines. Immunohistochemistry showed that AIM expression was observed in the cytoplasm of the HS cells. CD36, a candidate AIM receptor, was also observed on the cell membrane of HS cells. When the serum AIM level was detected in 36 dogs with HS and 10 healthy dogs via western blot analysis, the AIM levels in the HS dogs were significantly higher than those in the controls. AIM mRNA expression in the 5 HS cell lines varied but was higher than that in the other tumour‐derived lines. Among the five HS cell lines, DH82 originally had lower AIM and the highest CD36 expression. When AIM was overexpressed in DH82, therein cell growth speed and invasion, apoptosis inhibition and phagocytic activity were strongly upregulated. These data suggest that elevated intra‐tumour expression of AIM could induce the progression of HS cells in dogs. Moreover, elevated serum AIM levels in dogs with HS could serve as a biomarker of HS.
Mitogenomic phylogeny of Muricidae (Gastropoda: Neogastropoda)
Authors: Yu Yi , Kong Lingfeng , Li Qi 
Published: April 2023

AbstractMuricidae is one of the most species‐rich and morphologically diverse families in Gastropoda, with a worldwide distribution. The classification of Muricidae has traditionally been based on shell and radular characteristics; however, the phylogenetic relationships within the family are debated due to morphological convergence and plasticity. In this study, to explore the phylogenetic relationships of Muricidae, we sequenced 11 muricid mitochondrial (mt) genomes and compared them with 13 previously reported complete muricid mt genomes. All muricid mt genomes shared the same gene arrangement and exhibited conserved genome size and nucleotide composition. Three‐nucleotide deletions in atp8 and nad4, and three‐nucleotide insertions in nad2 were detected in Rapaninae. Both maximum likelihood and Bayesian inference analyses supported the monophyly of each subfamily studied (Ocenebrinae, Muricinae, Rapaninae and Ergalataxinae). Ergalataxinae was recovered as the sister taxon of Rapaninae, refuting the traditional morphology‐based placement of Ergalataxinae within Rapaninae. In Rapaninae, Indothais was confirmed to be monophyletic and determined to be a valid genus. Similarly, Drupina was determined to be an independent genus rather than a subgenus of Drupa. Purpura was recovered as a paraphyletic group, with Purpura panama being sister to Reishia + Rapana + Indothais and clustering with Purpura bufo.
Thompson's group F$F$ is almost 32$\frac{3}{2}$‐generated
Authors: Golan‐Polak Gili 
Published: April 2023

AbstractRecall that a group is said to be ‐generated if every nontrivial element of belongs to a generating pair of . Thompson's group was proved to be ‐generated by Donoven and Harper in 2019. It was the first example of an infinite finitely presented noncyclic ‐generated group. Recently, Bleak, Harper, and Skipper proved that Thompson's group is also ‐generated. In this paper, we prove that Thompson's group is “almost” ‐generated in the sense that every element of whose image in the abelianization forms part of a generating pair of is part of a generating pair of . We also prove that for every nontrivial element , there is an element such that the subgroup contains the derived subgroup of . Moreover, if does not belong to the derived subgroup of , then there is an element such that has finite index in .
Secukinumab improves physical function and quality of life and inhibits structural damage in patients with PsA with sustained remission or low disease activity: results from the 2-year phase 3 FUTURE 5 study
Authors: Coates Laura C , Mease Philip J , Gladman Dafna D , Navarra Sandra , Bao Weibin , Gaillez Corine 
Published: April 2023

ObjectiveTo investigate the impact of sustained low disease activity (LDA)/remission (REM) on physical function, quality of life (QoL) and structural outcomes in secukinumab-treated psoriatic arthritis (PsA) patients from the FUTURE 5 study.MethodsFUTURE 5 was a randomised, double-blind, placebo-controlled, parallel-group, phase 3 study in patients with active PsA. Patients were categorised according to LDA (Minimal Disease Activity, MDA/Disease Activity index for Psoriatic Arthritis, DAPSA LDA+REM) or REM (very LDA/DAPSA REM): not achieving LDA/REM, achieving it once or sustained LDA/REM ≥3 times up to week 104. Key outcomes were improvements in Health Assessment Questionnaire Disability Index and Short Form-36 Physical Component Summary Score, proportion of non-radiographic progressors and predictors of sustained LDA response.ResultsPatients were randomised (N=996) into the following treatment groups: secukinumab 300 mg (N=222), secukinumab 150 mg loading (N=220)/non-loading (N=222) and placebo (N=332). Baseline characteristics were comparable between patients with sustained DAPSA and MDA responses. By week 104, 48%–81% and 19%–36% of the secukinumab-treated patients achieved sustained LDA and REM, respectively. Numerically greater improvements in physical function and QoL were observed with sustained LDA/REM versus LDA/REM achieved once or not at all, although patients reached the established minimal clinically important difference for all composite indices. A high proportion of secukinumab-treated patients were non-structural progressors at 2 years irrespective of achieving sustained LDA/REM. Younger age, lower body mass index at baseline, reduced tender joint count and PsA pain at week 16 were key predictors of sustained LDA in secukinumab-treated patients.ConclusionSustained LDA/REM was associated with improvements in physical function, QoL and inhibition of structural damage progression.
Constraining primordial non-Gaussianity by combining next-generation galaxy and 21 cm intensity mapping surveys
Authors: Jolicoeur Sheean , Maartens Roy , Dlamini Simthembile 
Published: April 2023

AbstractSurveys of the matter distribution contain ‘fossil’ information on possible non-Gaussianity that is generated in the primordial Universe. This primordial signal survives only on the largest scales where cosmic variance is strongest. By combining different surveys in a multi-tracer approach, we can suppress the cosmic variance and significantly improve the precision on the level of primordial non-Gaussianity. We consider a combination of an optical galaxy survey, like the recently initiated DESI survey, together with a new and very different type of survey, a 21 cm intensity mapping survey, like the upcoming SKAO survey. A Fisher forecast of the precision on the local primordial non-Gaussianity parameter $$f_{\textrm{NL}}$$

f
NL

, shows that this multi-tracer combination, together with non-overlap single-tracer information, can deliver precision comparable to that from the CMB. Taking account of the largest systematic, i.e. foreground contamination in intensity mapping, we find that $$\sigma (f_{\textrm{NL}}) \sim 4$$

σ
(

f
NL

)
∼
4

.
Quantum identity authentication based on the extension of quantum rotation
Authors: Chen Geng , Wang Yuqi , Jian Liya , Zhou Yi , Liu Shiming 
Published: April 2023

AbstractIn this work, we propose a bit-oriented QIA protocol based on special properties of quantum rotation and the public key cryptographic framework. The proposed protocol exhibited good resistance to both forward search and measure-resend attacks, whereby its security performance was directly related to the length of the authentication code. From our analysis, it was demonstrated that the protocol has good performance, in terms of quantum bit efficiency. In addition, the protocol is well-expandable. The developed protocol is resource-efficient and can be also applied in quantum computing networks.
Filosofia e humanidades: as blindagens de uma historiografia sexista
Authors: Frateschi Yara 
Published: April 2023

O presente artigo é marcado pela preocupação em alargar o chamado cânone da filosofia ocidental, patrocinada pela tradição filosófica e sua narrativa triunfalista, levada a cabo pela história da filosofia de ontem e de hoje, com sua disposição de celebrar a Filosofia mainstream e as grandes mentes masculinas, como Kant e Descartes. Trata-se de alargar o cânone filosófico e de relançar o projeto das humanidades, em defesa de uma “história da filosofia aberta e feminista”, tendo ao centro Elisabeth da Bohemia, Emilie du Châtelet, Madame de Scudéry e Madeleine de Sablé, além de Macaulay e Christine de Pizan.
Thoracic Spinal Cord Neuroinflammation as a Novel Therapeutic Target in Pulmonary Hypertension
Authors: Razee Asif , Banerjee Somanshu , Hong Jason , Magaki Shino , Fishbein Greg , Ajijola Olujimi A. , Umar Soban 
Published: April 2023

Background:
Pulmonary hypertension (PH) is associated with aberrant sympathoexcitation leading to right ventricular failure (RVF), arrhythmias, and death. Microglial activation and neuroinflammation have been implicated in sympathoexcitation in experimental PH. We recently reported the first evidence of thoracic spinal cord (TSC) neuroinflammation in PH rats. Here, we hypothesize that PH is associated with increased cardiopulmonary afferent signaling leading to TSC-specific neuroinflammation and sympathoexcitation. Furthermore, inhibition of TSC neuroinflammation rescues experimental PH and RVF.

Methods:
We performed transcriptomic analysis and its validation on the TSC of monocrotaline (n=8) and Sugen hypoxia (n=8) rat models of severe PH-RVF. A group of monocrotaline rats received either daily intrathecal microglial activation inhibitor minocycline (200 μg/kg per day, n=5) or PBS (n=5) from day 14 through 28. Echocardiography and right ventricle-catheterization were performed terminally. Real-time quantitative reverse transcription PCR, immunolocalization, microglia+astrocyte quantification, and terminal deoxynucleotidyl transferase dUTP nick end labeling were assessed. Plasma catecholamines were measured by ELISA. Human spinal cord autopsy samples (Control n=3; pulmonary arterial hypertension n=3) were assessed to validate preclinical findings.

Results:
Increased cardiopulmonary afferent signaling was demonstrated in preclinical and clinical PH. Our findings delineated common dysregulated genes and pathways highlighting neuroinflammation and apoptosis in the remodeled TSC and highlighted increased sympathoexcitation in both rat models. Moreover, we validated significantly increased microglial and astrocytic activation and CX3CL1 expression in TSC of human pulmonary arterial hypertension. Finally, amelioration of TSC neuroinflammation by minocycline in monocrotaline rats inhibited microglial activation, decreased proinflammatory cytokines, sympathetic nervous system activation and significantly attenuated PH and RVF.

Conclusions:
Targeting neuroinflammation and associated molecular pathways and genes in the TSC may yield novel therapeutic strategies for PH and RVF.
Frequency and Size of In Situ Thrombus Within Patent Foramen Ovale
Authors: Yan Chaowu , Li Hua , Wang Cheng , Yu Hang , Guo Tingting , Wan Linyuan , Yundan Pingcuo , Wang Lei , Fang Wei 
Published: April 2023

Background:
High-resolution optical coherence tomography can detect in situ thrombi within patent foramen ovale (PFO), which can become a dangerous embolic source. This study aimed to investigate the frequency and size of in situ thrombus within PFO using optical coherence tomography.

Methods:
The cross-sectional study was conducted at Fuwai Hospital (Beijing, China) between 2020 and 2021. From 528 consecutive patients with PFO, 117 (age, 34.33 [SD, 11.30] years) without known vascular risk factors were included; according to PFO-related symptoms, they were divided into the stroke (n=43, including 5 patients with transient ischemic attack), migraine (n=49) and asymptomatic (n=25) groups. Optical coherence tomography was used to evaluate in situ thrombi and abnormal endocardium within PFO. Univariable analysis and a logistic model were used to evaluate the association between stroke and in situ thrombus; age, sex, body mass index, and antithrombotic therapy were included as covariates.

Results:

Antithrombotic therapy was used more frequently in the stroke group than in the migraine group (76.7% versus 12.2%;
P
<0.001). In situ PFO thrombi were detected in 36 (83.7%), 28 (57.1%), and 0 (0.0%) patients from the stroke, migraine, and asymptomatic groups, respectively (
P
<0.001). Between the stroke and migraine groups, there was no significant difference in the median (interquartile range) thrombus number per patient (7 [3–12] versus 2 [0–10];
P
=0.199), maximum thrombus diameter (0.35 [0.20–0.46] versus 0.21 [0–0.68] mm;
P
=0.597), or total thrombus volume (0.02 [0.01–0.05] versus 0.01 [0–0.05] mm
3
;
P
=0.386). Additionally, in situ thrombus was significantly associated with stroke risk (odds ratio, 4.59 [95% CI, 1.26–16.69]). Abnormal endocardium within PFO occurred in patients with in situ thrombi (71.9%) but not in those without. During optical coherence tomography examination, migraine occurred in 2 patients with in situ thrombi.

Conclusions:
The frequency of in situ thrombus was extremely high in stroke and migraine groups, while none of the asymptomatic individuals presented with an in situ thrombus. In situ thrombus formation may play a role in patients with PFO-associated stroke or migraines and have therapeutic implications.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04686253.
Natural Resource Rents, Local Taxes, and Government Performance: Evidence from Colombia
Authors: Martínez Luis R. 
Published: April 2023

Abstract
I compare the impact of local tax revenue and royalties from the extraction of natural resources on governance in Colombian municipalities, leveraging plausibly exogenous variation from cadastral updates and fluctuations in the world price of oil. Higher tax revenue has a larger effect on local public goods in the areas of education, health, and water than a same-sized increase in oil royalties, despite earmarking of royalties for spending in these areas. Higher tax revenue also reduces the probability of a disciplinary prosecution against the municipal mayor, while the opposite is true for royalties, particularly for misbehavior related to public spending.
Sibling Differences in Genetic Propensity for Education: How Do Parents React?
Authors: Sanz-de-Galdeano Anna , Terskaya Anastasia 
Published: April 2023

Abstract
We take advantage of recent advances in genomics to revisit a classic question in economics: how do parents respond to children's endowments and to sibling differences in endowments? We use an index based on DNA, which is fixed at conception and assigned randomly across siblings, as a proxy for educational endowments. We find that parents of nontwins display inequality aversion: given the absolute endowment level of one child, they invest less in him/her if his/her sibling has a lower genetic predisposition to education. In contrast, we find no evidence that parents of dizygotic twins react to endowment differences between children.
High-Skill Migration, Multinational Companies and the Location of Economic Activity
Authors: Morales Nicolas 
Published: April 2023

Abstract
This paper aims to understand the relationship between high-skill immigration and multinational activity. I assemble a novel firm-level dataset on high-skill visas and show that there is a large home bias effect: foreign multinationals hire more immigrants from their home countries than from other origins. I then build and estimate a quantitative model that relates multinational production with immigration. First, I impose a restrictive immigration policy in the US and evaluate how it affects production and wages. Second, I increase the barriers to multinational production and show that immigration is an important channel to quantify the welfare gains generated by multinationals.
Developing Impacts-Based Drought Thresholds for Ohio
Authors: Zhang Ning , Li Zhiying , Quiring Steven M. 
Published: April 2023

Abstract
Drought monitoring is critical for managing agriculture and water resources and for triggering state emergency response plans and hazard mitigation activities. Fixed thresholds serve as guidelines for the U.S. Drought Monitor (USDM). However, fixed drought thresholds (i.e., using the same threshold in all seasons and climate regions) may not properly reflect local conditions and impacts. Therefore, this study develops impacts-based drought thresholds that are appropriate for drought monitoring in Ohio. We examined four drought indices that are currently used by the state of Ohio: standardized precipitation index (SPI), standardized precipitation evapotranspiration index (SPEI), Palmer’s Z index, and Palmer hydrological drought index (PHDI). Streamflow and corn yield are used as indicators of hydrological and agricultural drought impacts, respectively. Our results show that fixed thresholds tend to indicate milder drought conditions in Ohio, while the proposed impacts-based drought thresholds are more sensitive to exceptional drought (D4) conditions. The area percentage of D4 based on impacts-based drought thresholds is more strongly correlated with corn yield and streamflow. This study provides a methodology for developing local impacts-based drought thresholds that can be applied to other regions where long-term drought impact records exist to provide regionally representative depictions of conditions and improve drought monitoring.
The Prediction of Supercooled Large Drops by a Microphysics and a Machine Learning Model for the ICICLE Field Campaign
Authors: Jensen Anders A. , Weeks Courtney , Xu Mei , Landolt Scott , Korolev Alexei , Wolde Mengistu , DiVito Stephanie 
Published: April 2023

Abstract
The prediction of supercooled large drops (SLD) from the Thompson–Eidhammer (TE) microphysics scheme—run as part of the High-Resolution Rapid Refresh (HRRR) model—is evaluated with observations from the In-Cloud Icing and Large drop Experiment (ICICLE) field campaign. These observations are also used to train a random forest machine learning (ML) model, which is then used to predict SLD from several variables derived from HRRR model output. Results provide insight on the limitations and benefits of each model. Generally, the ML model results in an increase in the probability of detection (POD) and false alarm rate (FAR) of SLD compared to prediction from TE microphysics. Additionally, the POD of SLD increases with increasing forecast lead time for both models, likely since clouds and precipitation have more time to develop as forecast length increases. Since SLD take time to develop in TE microphysics and may be poorly represented in short-term (<3 h) forecasts, the ML model can provide improved short-term guidance on supercooled large-drop icing conditions. Results also show that TE microphysics predicts a frequency of SLD in cold (<−10°C) or high ice water content (IWC) environments that is too low compared to observations, whereas the ML model better captures the relative frequency of SLD in these environments.