bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signaling
Authors: Wu Peng V. , Fish Matt , Hazard Florette K. , Zhu Chunfang , Vennam Sujay , Walton Hannah , Morri Maurizio , Neff Norma , West Robert B. , Nusse Roel 
Published: June 2023

SUMMARYCancers evolve not only through the acquisition and clonal transmission of somatic mutations but also by non-genetic mechanisms that modify cell phenotype. Here, we describe how transcriptional heterogeneity arises within human hepatoblastoma, one of the cancers with the lowest mutational burden, characterized by activating mutations in the Wnt pathway. Histology-guided RNA sequencing and evaluation of spatial gene expression in primary hepatoblastomas identified foci of tumor cells within the highly proliferative embryonal histology that express the growth factor FGF19, colocalizing with markedly increased expression of Wnt target genes and cholangiocyte markers. In patient-derived tumoroids, FGF19 provided a required growth signal for FGF19-negative cells, and its expression depended on both Wnt/μ-catenin and the biliary transcription factor SOX4. Our results reveal that a biliary lineage program induces FGF19 as a paracrine signal for tumor growth, thereby modulating the transcriptional outcome of constitutive Wnt activation and tumor cell proliferation.
BiallelicPARP1Mutations Associated with Childhood-Onset Neurodegeneration
Authors: Hailstone Richard , Maroofian Reza , Woodbine Lisa , Korneeva Elena , Brazina Jan , Macaya Alfons , Severino Mariasavina , Tomoum Hoda , Houlden Henry , Caldecott Keith W 
Published: June 2023

SummaryPARP1 is the primary human sensor protein for DNA single-strand breaks, reduced repair of which results in neurodevelopmental and/or progressive neurodegenerative disease typified by cerebellar ataxia, and oculomotor apraxia. Here, we report the first such disease associated with hereditary mutations inPARP1. The affected individual possesses biallelic mutations in the second DNA strand-break sensing zinc finger of PARP1, resulting in a predicted truncated protein of 127 amino acids that is comprised of just the first DNA strand-break sensing zinc finger. Levels of oxidative DNA damage-induced PARP activity are greatly reduced (∼80%) in primary fibroblasts derived from the patient, when compared to cells derived from the parents, and levels of endogenous S-Phase PARP activity are reduced by >50%. Critically, whereas DNA double-strand break repair and cellular sensitivity to ionising radiation are largely normal in the patient-derived cells, the rate of repair of DNA single-strand breaks induced by either oxidative stress, during DNA base excision repair, or as a result of cytotoxic topoisomerase I activity is reduced. These data implicate hereditary mutations PARP1 in human hereditary neurodegenerative disease, and increase to five the number of DNA single-strand break repair genes associated with progressive cerebellar ataxia and oculomotor apraxia.
Corporate social responsibility expenditure and financial performance: the moderating role of family ownership
Authors: Kaimal Anjali , Uzma Shigufta Hena 
Published: June 2023

Purpose
The paper aims to examine how Indian non-financial service sector companies’ financial performance is influenced by their corporate social responsibility (CSR) expenditures. The paper also analyses whether family ownership has a moderating role in the CSR expenditure–financial performance association.

Design/methodology/approach
The study includes 288 non-financial service sector companies listed in India with 3,456 firm-year observations. Panel data regression analysis using data for 12 years, starting from 2010 to 2021, is carried out.

Findings
The study reveals a positive influence of CSR spending on financial performance measures (Tobin’s Q and return on assets). Mandatory CSR policies also influence the company’s performance. Additionally, family ownership has a positive moderating effect on CSR expenditure–financial performance (Tobin’s Q).

Research limitations/implications
The study gives insights to the managers on how CSR expenditures can be used to maximise their benefits by supporting social causes, particularly in the case of firms with ownership structures where family involvement is there.

Originality/value
The prior studies analysing family ownership effect on the CSR–financial performance relationship are fewer, and in a country like India, where corporate philanthropy is a part of the family business culture, there is a need to understand how CSR spending influences firm performance.
The mediating role of intellectual capital in corporate governance and financial efficiency of Islamic banks
Authors: Aslam Ejaz , Ur Rehman Aziz , Iqbal Anam 
Published: June 2023

Purpose
The purpose of this study is to investigate the mediating role of intellectual capital (IC) on the association between corporate governance mechanism (CGM) and the financial efficiency of Islamic banks (Z-score, net investment income and loan to deposit) and verify it through standard mediation in the panel based on interaction.

Design/methodology/approach
The data of this study draws from 125 full-fledged Islamic banks and windows from 26 Organization of Islamic Cooperation (OIC) over the period of 2009 to 2019. A two-step system generalize method of moment estimation is used to test the hypotheses.

Findings
The results underwrite that the inclusion of IC as a mediating variable has influenced positively the corporate governance and financial efficiency of IBs. Besides, only CEO power and Shariah supervisory board positively affect the financial efficiency of IBs. While structural capital and relational capital positively affect the financial efficiency of IBs. Apart from that, results show that the CGM has a significant relationship with the IC value of IBs.

Research limitations/implications
These findings are valuable for policymakers and regulators to set policies to improve CG structure and effective use of IC resources to improve banking efficiency. Additionally, findings might be helpful for the bankers to proficiently use the IC as a premise to plan new strategies to get an upper hand in financial performance.

Originality/value
This study extends and contributes to the current literature by analysing the role of IC along with CG to boost the financial efficiency of banks in OIC countries.
Greenhouse gas assurance, board diversity and cost of debt: a quantile approach
Authors: Koutoupis Andreas G. , Davidopoulos Leonidas G. , Azibi Jamel , Hakimi Abdelaziz , Mansali Hatem 
Published: June 2023

PurposeThe authors examine the effect of greenhouse gas (ghg) assurance on cost of debt, and the effect of board gender diversity on cost of debt, for an international sample of listed companies.Design/methodology/approachUtilizing firm-level data and a quantile regression approach, this study examines the effects of greenhouse gas assurance and board diversity on cost of debt by employing an international sample of firms during 2015–2021.FindingsThe authors find that in firms with a relatively low cost of debt the external assurance of greenhouse gas emissions and gender diversity could significantly contribute to a reduction of cost of debt. Furthermore, other measures of board diversity that are linked with independent directors and skilled directors seem to contribute to an increase of firms' cost of debt in the lower end of distribution. Drawing from the agency theory, the authors showcase the fact that ghg assurance reduces information asymmetry and therefore agency costs such as borrowing costs and signals to the stakeholders a long-term commitment to excellence.Originality/valueThis study is the first that provides insights on the relationship between ghg assurance, board diversity and cost of debt.
Does technological innovation have an impact on employment in the hospitality industry?
Authors: Tian Jiawen 
Published: June 2023

Purpose
This study aims to empirically analyze the impact of technological innovation on the quantity and quality of employment in the hospitality industry.

Design/methodology/approach
Using the data of 30 provinces in China from 2010 to 2020, this paper makes an empirical analysis through the fixed effect model.

Findings
The results show that process innovation has a significant positive impact on employment quantity, while product innovation has a significant negative impact on employment quantity. The creative effect of process innovation and the substitution effect of product innovation offset each other, so in the long run, the impact of technological innovation on employment quantity is not significant. However, technological innovation has significantly improved the employment quality of the hospitality industry.

Practical implications
Because technological innovation has replaced part of the labor force, hospitality could guide the labor force in a positive direction. To promote innovation and retain talents, hotels should train employees’ digital thinking and attract high-skilled talents.

Originality/value
This research is unique in using process innovation and product innovation as the main measurement indicators of technological innovation, unlike previous studies that often relied on technological progress to conclude.
Workplace spirituality to cultivate innovative work behaviour: the moderating role of perceived working conditions
Authors: Garg Naval , Saini Damini 
Published: June 2023

PurposeThe purpose of the present study is to contribute to the debate on innovative work behaviour (IWB). Employees are expected to exhibit innovative behaviour that can realize, sustain and implement new ideas. This study explores the role of workplace spirituality (WPS) in advancing employees' innovative work behaviour (IWB). Furthermore, this study investigates how employees' perceived working conditions moderate the relationship between WPS and IWB.Design/methodology/approachThe sample comprised 516 employees working in different supply chain companies in India. The researchers used correlation, hierarchical regression analysis and the PROCESS macro in SPSS.FindingsThe results highlighted that the four measurements of WPS (Swadharma, a sense of community, authenticity and Lokasangraha) significantly predict IWB among employees of selected companies. Also, the results suggested the significant moderating effects of decision authority, social support and autonomy on IWB.Originality/valueDrawing from broaden and build theory and theory of intangible resources, the present study demonstrates that WPS positively impacts the employee's IWB. Further, this paper also shows the moderating effects of three dimensions of perceived working conditions between WPS and IWB, which is under-explored in previous research.
Secondhand clothing purchase intentions: Generation Z’s perspective
Authors: Herjanto Halimin , Amin Muslim , Purinton Elizabeth , Lindle II Edward L. 
Published: June 2023

Purpose
Based on the learning and attitudinal theories, this study aims to investigate the direct effect of two type of experiences, attitude and the indirect impact of fashion innovativeness, materialism and financial pressure on Generation Z’s secondhand clothing (SHC) purchase intention.

Design/methodology/approach
A total of 180 usable surveys were gathered from Generation Z participants and analyzed by a partial least-square-structural equation model.

Findings
The results show that attitude (SHC hygiene vs SHC fashion style) and past experiences (daily use occasion vs particular use occasion) directly affect SHC purchase intention. Furthermore, materialism, financial pressure and innovativeness drive attitudes toward SHC fashion style.

Originality/value
This study extends the current SHC literature by integrating two dimensions of experience (daily use occasion vs particular use occasion) and attitude (attitude toward SHC hygiene vs attitude toward SHC style).
Dispositions towards learning: the importance of epistemic attributes for postgraduate learners
Authors: Spray Erika , Holbrook Allyson , Scevak Jill , Cantwell Robert 
Published: June 2023

Purpose
Learners’ dispositional attributes form the foundations for their learning behaviour and therefore academic outcomes. This study aims to explore the dispositional attributes of postgraduate learners in coursework programs, and to understand the relationships between dispositional attributes and academic achievement at this level.

Design/methodology/approach
This study profiled the dispositions towards learning of 880 Master’s students in Australia, reported in an online survey. Statistical analysis was used to explore the possibility of underlying dispositional dimensions and latent clusters of participants within the cohort.

Findings
The profile of the cohort overall was as expected for an elite academic group, yet there was substantial variation between individuals. Cluster analysis identified three groups of students with meaningfully different dispositional profiles. Exploratory factor analysis revealed two underlying dispositional dimensions, representing epistemic and agentic attributes. Epistemic attributes were most closely related to academic achievement.

Practical implications
It is argued that students at Master’s level typically possess the agentic attributes necessary for effective self-regulation. At this level, therefore, epistemic attributes are more relevant for differentiating between higher and lower achieving students. The attainment of sophisticated epistemic attributes is in line with the stated goals of postgraduate education. This supports the explicit teaching of metacognitive and epistemic skills within postgraduate degrees.

Originality/value
This study contributes a detailed analysis of Master’s students’ dispositional profiles. Two underlying dispositional dimensions are identified, representing agentic and epistemic attributes. The importance of epistemic attributes for postgraduate academic achievement identifies an opportunity for targeted interventions to raise the quality of learning at this level.
The past is prologue part II: a study of PDS comparison dissertations
Authors: Yendol-Hoppey Diane , Garin Eva 
Published: June 2023

PurposeThe study aims to present a logic map linking the Professional Development School (PDS) Nine Essentials as a PDS theory of action and offer an analysis of dissertations that compare outcomes of learning in PDS and non-PDS contexts.Design/methodology/approachFor this current study, the authors identified 25 of the 210 dissertations from a larger study that used a comparison methodology to provide a window into how learning in PDS and non-PDS settings may differ. In reviewing these comparison studies, the authors identified a set of clustered themes, as well as a variety of comparison constructs and measurements researchers used to determine the impact of PDS.FindingsFive themes emerged including (1) the experience of learning to teach in a PDS setting vs. a non-PDS; (2) the experience of teaching in a PDS vs. non-PDS; (3) teacher candidate quality in a PDS vs. non-PDS; (4) teacher quality in a PDS vs. non-PDS; (5) school leader quality in a PDS vs. non-PDS; and (6) K-12 student learning in PDS vs. non-PDS.Research limitations/implicationsLimitations of this study include the complications related to comparison, logic-related fallacies and the complexity of capturing simultaneous renewal.Originality/valueIn the 30th year of PDS work, the study utilizes a theory of action comprised of linking the PDS Nine Essentials to situate the comparison dissertation analysis of outcomes in PDS and non-PDS contexts suggesting challenges and possibilities and perhaps a direction for new research questions.
Characterization and optimization of weld properties due to the effect of different pin profiles for AA8011 – based friction stir welding
Authors: Lonavath Srinivas Naik , Boda Hadya 
Published: June 2023

Purpose
This Friction stir welding study aims to weld thick AA8011 aluminium plates, and the interface joints created with a variety of tool pin profiles were examined for their effects on the welding process.

Design/methodology/approach
Scanning electron microscopy and optical microscopy and X-ray diffraction were used to examine the macro and micro-structural characteristics, as well as the fracture surfaces, of tensile specimens. The mechanical properties (tensile, hardness tests) of the base metal and the welded specimens under a variety of situations being tested. Additionally, a fracture toughness test was used to analyse the resilience of the base metal and the best weldments to crack formation. Using a response surface methodology with a Box–Behnken design, the optimum values for the three key parameters (rotational speed, welding speed and tool pin profile) positively affecting the weld quality were established.

Findings
The results demonstrate that a defect-free junction can be obtained by using a cylindrical tool pin profile, increasing the rotational speed while decreasing the welding speeds. The high temperature and compressive residual stress generated during welding leads to the increase in grain size. The grain size of the welded zone for optimal conditions is significantly smaller and the hardness of the stir zone is higher than the other experimental run parameters.

Originality/value
The work focuses on the careful examination of microstructures behaviour under various tool pin profile responsible for the change in mechanical properties. The mathematical model generated using Taguchi approach and parameters was optimized by using multi-objectives response surface methodology techniques.
Training the ageing bodies: New knowledge paradigms and professional practices in elderly care
Authors: Kamp Annette , Dybbroe Betina 
Published: June 2023

AbstractIn the Scandinavian countries, reablement has become a principle permeating all parts of elderly care, hence potentially transforming care and care work. This article explores the advent of new knowledge paradigms and practices of physiotherapists and occupational therapists transforming reabling care in particular ways, leading to what we term a logic of training emerging in the field. These professional groups have obtained a dominant position as reablement specialists in Norway and Denmark, where our extensive fieldwork was performed as part of a 3‐year research project. Taking inspiration from Annemarie Mol’s concept of logic, we study how professional practices are organised and infused with specific values, meanings and ideals in situated contexts. We hence explore the logic of training, its abstracted image of the body and rational goal‐oriented model for progress measurement and its ramifications when addressing ageing bodies in a complex field marked by the unpredictabilities of the social and lived bodies, administrative rules and temporalities and the quest for empowering and involving clients. The paper concludes by pointing at new contradictions arising when practicing reabling care and particularly points out the tensions arising in care relations, where ambitions on empowering and disciplining the client and the elderly body may collide.
Investigating cost non‐attendance as a driver of inflated welfare estimates in mixed‐logit models
Authors: Rollins Curtis 
Published: June 2023

AbstractChoice models are used by applied economists for many purposes, such as non‐market valuation or estimating willingness to pay for novel food and product attributes. Mixed‐logit models allow researchers to account for preference heterogeneity and complex decision‐making processes when modelling choices. In mixed‐logit models, parameters of monetary attributes such as prices typically are assumed to follow a negative lognormal random distribution to ensure that the marginal utility of a price increase is strictly negative. However, this practice can cause means and standard deviations of welfare estimates to ‘explode’ to unfeasibly large levels, as the model assumes there are some marginal utilities of cost approaching zero. This paper examines whether cost non‐attendance, which occurs when respondents ignore costs in stated‐preference studies, could be a cause of inflated welfare estimates when a lognormal cost parameter is used. A two‐class equality‐constrained latent‐class model is proposed, in which the cost parameter is fixed at zero for a cost non‐attender class and is specified as a random lognormal parameter for cost attenders. This proposed model produces mean welfare estimates that are 17 times lower than a mixed‐logit model with a lognormal cost parameter, and 10% lower than a model with a non‐random cost parameter. These results suggest that cost non‐attendance can result in inflated welfare estimates when employing a lognormal cost parameter, and that accounting for cost non‐attendance could be a simple, parsimonious solution to this problem.
‘There will be no shortage of Cabinet ministers taking part in the Scottish referendum campaign. The same is not true in Wales’: New Labour, Old Struggles, and the Advent of Welsh Devolution*
Authors: Evans Adam 
Published: June 2023

AbstractDevolution to Scotland and Wales was a central pillar of the legislative agenda of the Labour government elected in 1997, yet despite the constitutional significance of this programme it was undertaken without particular enthusiasm by the then prime minister, Tony Blair. Nowhere was this blend of significant change, yet pervasive lack of passion (or interest) more apparent than devolution to Wales. Drawing upon recently released archival documents, this article will explore the New Labour government's approach to devolution in Wales.These papers provide fresh evidence of the second order nature, and treatment, of Welsh devolution compared to the attention provided to Scottish devolution, as well as of the narcissism of small details which pervaded Whitehall's discussions of Welsh devolution (with considerable energy, for example, dedicated to questions about the titles which leading figures in the Assembly would be given). These papers also bear testament to the struggles which Ron Davies, the then secretary of state for Wales, faced in securing even a minor scheme of devolution and the tensions he experienced with the centre of government.
Legal Geographies of Displacement through Renovation: Legal Interpretative Practices in Sweden
Authors: Polanska Dominika V. 
Published: June 2023

AbstractHow the legal is implicated in the production of space and how displacement is both a material and discursive process stands at the fore of this study. The aim is to examine how the law is interpreted in cases of approval of renovation of rental housing and how these interpretations are articulated, presented, and justified in the Swedish context. Questions on what definitions and justifications are used in the interpretative legal practice are linked to processes of discursive displacement of tenants. It is argued that the unequal relationship between property owners and tenants is sustained in this legal practice through the techniques of abstracting, naturalising, and shifting responsibility, and uncritically reproducing financial logics, thus contributing to discursive displacement of tenants. The arguments of tenants are silenced and circumscribed with economic and technical reasons, along with narrow and vague definitions, reflecting a position of privilege, and reproducing the politics of property.