bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiotoxicity in breast cancer patients receiving trastuzumab with or without prior anthracycline-based chemotherapy
Authors: Ray Arpita , Kalita Naba Kumar , Mahanta Neelakshi , Ali Alfarid Shahid , Kashyap Madhav 
Published: December 2022

Background:
Trastuzumab (Herceptin) is used in human epidermal growth factor receptor-2 (HER2)-positive breast cancer patients either alone or in combination with various chemotherapeutic agents in the neoadjuvant, adjuvant as well as palliative settings. Cardiotoxicity remains an issue of concern with the use of trastuzumab which may be enhanced with the prior use of anthracycline-based chemotherapeutic agents.

Aim:
This prospective study was conducted with the aim of identifying the occurrence of cardiotoxicity in patients receiving trastuzumab with or without a history of prior use of anthracycline-based chemotherapy.

Materials and Methods:
The study was conducted over a period of 1½ years. All the HER2-positive breast cancer patients who received trastuzumab-based therapy in adjuvant as well as maintenance settings and the cardiotoxicity in terms of drop in left ventricular ejection fraction (LVEF) from the lower limit of normal range were evaluated. A significant drop is defined when LVEF drop is >10%. Cardiotoxicity was compared between those who received prior anthracycline-based chemotherapy versus nonanthracycline-based chemotherapy.

Results:
A total of 62 HER2-positive breast cancer patients who fulfilled the inclusion and exclusion criteria were enrolled for analysis. Thirty-two patients received prior anthracycline-based chemotherapy and 30 patients received nonanthracycline-based chemotherapy. A significant drop in LVEF of >10% was found in 20 out of 62 patients (32.3%). This significant drop in LVEF was found more in those patients who received prior anthracycline-based chemotherapy (n = 15) versus who did not receive prior anthracycline-based chemotherapy (n = 5) (46.9% vs. 16.7%; P = 0.0109).

Conclusion:
Trastuzumab-induced cardiotoxicity (LVEF drop >10%) is higher among breast cancer patients who received prior anthracycline-based chemotherapy as compared to those who did not receive prior anthracycline. This clinically significant drop in LVEF warranted an interruption in the treatment till stabilization and improvement of the cardiac function.
Anti-proliferative activities of 4H-pyran derivatives synthesized from benzoylacetone
Authors: M. Mohareb Rafat , A. Ibrahim Bishoy , Omar Al Farouk Fatma 
Published: December 2022

ABSTRACT. Benzoylacetone (1) underwent a series of multi-component reactions with aromatic aldehydes and malononitrile or ethyl cyanoacetate to produce the pyran derivatives 4a-f. The latter compounds reacted with malononitrile or ethyl cyanoacetate to yield the condensation products 5a-m. On the other hand, the reaction of 4a-f with either the diazonium salts 6a-c yielded the arylhydrazone derivatives 7a-i. The multi-component reaction of (1) with aromatic adehydes and cyclohexan-1,3-dione produced the pyran derivatives 9a-c. Compound 1 underwent the Gewald’s reactions with elemental sulfur and malononitrile or ethyl cyanacetate yielding the thiophene derivatives 10a,b. Evaluations of the synthesized products were carried out against some selected cancer cell lines and the most active compounds were further evaluated against the seventeen cancer cell lines classified according to the disease. Morphological changes of A549 cell line by the effect of compound 7k was studied using microenvironment of the lung tissue where an excellent results was obtained.

KEY WORDS: Benzoylacetone, Multi-component reactions, Pyran, Thiophene, Arylhydrazone, Cytotoxicity

Bull. Chem. Soc. Ethiop. 2023, 37(2), 405-425.
DOI: https://dx.doi.org/10.4314/bcse.v37i2.12
Influence of synthesized (green) cerium oxide nanoparticle with neem (Azadirachta indica) oil biofuel
Authors: Lenin Allasi Haiter , A. Rajalingam A. , P. Jani S. , Uppalapati Sudhakar 
Published: December 2022

ABSTRACT. Energy demand increases day by day due to the present technological scenario and fossil fuels are also depleting gradually. Therefore, the necessity came into the researchers to identify an alternative renewable resource for compensating the energy demand. The biodiesel appeared to the researchers as an important resource due to its characteristics and ability to compensate for the energy demand. However, some additional improvements are required for the efficient performance of the biodiesel, such improvement is achievable by the blending of an efficient additive with the biodiesel. The present study predominantly focuses to investigate the performance of the biodiesel with two different additives such as cerium oxide nanoparticles and ethanol. The neem (Azadirachta indica) oil has been selected as feed stock. The cerium oxide nanoparticles are prepared using the green synthesis process. Four various fuel samples are prepared to examine the effect of additives, (i) PB (pure biodiesel), (ii) BCe (PB+100 ppm CeO2), (iii) BE (90% biodiesel+10% ethanol) and (iv) BCeE (90% biodiesel+100 ppm CeO2+10% ethanol). From the experimentation, it is observed that the fuel BCeE achieves the better performance due to the oxygen buffering characteristics and improvement in the atomization by the additives.

KEY WORDS: Additives, Nanoparticles, Neem oil, Emission, Combustion, Heat release rate

Bull. Chem. Soc. Ethiop. 2023, 37(2), 477-490.
DOI: https://dx.doi.org/10.4314/bcse.v37i2.16
Investigation on silver-water nanofluid for development of new viscosity correlation
Authors: Iyahraja S. , Selwin Rajadurai J. , Sivakumar M. , N. Lenin N. 
Published: December 2022

ABSTRACT. The present study addresses an experimental investigation on the influence of the concentration of nanoparticles and temperature on nanofluid's viscosity and establishes a numerical correlation for predicting the nanofluid's viscosity. In this study, silver nanoparticles (Ag) with a size of 20 nm were used to prepare the nanofluid with water as the base fluid. The concentrations of silver nanoparticles were fixed as 0.01, 0.05, and 0.1% by volume in the range of temperature from 20 to 60oC. The findings of the current investigations report that the nanofluid's viscosity increases with volume fractions of nanoparticles and decreases as the temperature increases. The theoretical correlations in the literature under predict the viscosity of silver-water nanofluids, which has led to the development of a new relationship for determining the nanofluids' effective viscosity from the experimental findings of this research. The proposed model as outcome of the current investigation confirms a reasonable agreement with the experimental data.

KEY WORDS: Silver nanoparticles, Nanofluid, Viscosity, Volume Concentration, Temperature

Bull. Chem. Soc. Ethiop. 2023, 37(2), 505-514.
DOI: https://dx.doi.org/10.4314/bcse.v37i2.18
Factors Influencing Adherence to Antiretroviral Therapy (ART) among Adolescents Living with Human Immunodeficiency virus (HIV) in Rwanda
Authors: Habumugisha Emmanuel , Nyishimirente Sylvie , Katende Godfrey , Nkurunziza Aimable , Mukeshimana Madeleine , Ngerageze Innocent , Mukashyaka Joella 
Published: December 2022

Background
HIV continues to be an important public health concern among adolescents. To reduce the high rate of mortality and improve the quality of life among people with HIV, WHO guidelines emphasize the early initiation of ART drugs in HIV-infected persons regardless of their CD4 count and clinical status. However, adherence to ART remains low in adolescents between 10 to 19 years from low and middle-income countries (LMICs).
Objective
To determine the factors influencing adherence to ART among adolescents with HIV in Rwanda.
Method
A cross-sectional design using proportional stratified random sampling to select 166 adolescents was conducted. Data were analyzed using descriptive and inferential statistics with a p-value <0.05 and a CI of 95%.
Results
The overall adherence to ARTs was 38%. Assistance of clinical staff in taking medication (p<0.001) and the help of parents in taking medication (p<0.001) positively influenced adherence to ART. Insufficient health care providers, forgetfulness (p=0.009), and dosage too complex (p=0.044) negatively influenced adherence to ART.
Conclusion
Factors such as someone reminding adolescents to take medication, non-stigmatization, and absence of side effects were positively associated with ART adherence. On the other hand, forgetfulness, complex dosage, being isolated and inadequate education about medications negatively affect adherence to ARTs. There is a need to set strategies to increase adherence to ARTs, including expert clients and trustable guardians in care provision. All adolescents should receive adequate counselling and health education before the initiation of ARTs.
Rwanda J Med Health Sci 2022;5(3):251-263
Virtual patient simulation in pharmacy education: A systematic review
Authors: Beshir Semira Abdi , Mohamed Affana Parveen , Soorya Aadith , Sir Loon Goh Sheron , Moussa El-Labadd Eman , Hussain Nadia , Said Amira S.A. 
Published: December 2022

Background: This review summarises the impact of virtual patient simulation (VPS) on pharmacy students’ knowledge, skills, and perceptions.
Methods: The PubMed, Cochrane Library, and Web of Science databases were searched using relevant keywords. Full-text articles in English, published between 2010 and August 2021, were retrieved if they evaluate the impact of web-based interactive VPS in pharmacy education.
Results: This review included 19 studies, 9 of which were comparative. VPS was used to develop or assess different pharmacy-related skills. In general, post-VPS exposure test scores were better than the pre-VPS test scores in 12 studies. VPS significantly improved higher-level learning, counselling, and decision-making skills more than paper-based cases. The favourable impact of VPS on learners’ confidence, student engagement, and satisfaction was noted.
Conclusion: VPS enhances knowledge and clinical decision-making skills. It can also address the needs of pharmacy students with active learning preferences.
Characterizing Elements of Crimes Committed by Persons Sentenced to Deprivation of the Right to Hold Certain Positions or Engage in Certain Activities Provided for in Article 264.1 of the Criminal Code of the Russian Federation
Authors: Бородина А.М. 
Published: December 2022

Статья посвящена изучению повторных преступлений, связанных с уклоняющимся поведением, совершаемых лицами, осужденными к лишению права занимать определенные должности или заниматься определенной деятельностью. На основе статистических данных ФСИН России установлено, что наиболее часто осужденными рассматриваемой категории совершаются преступления, предусмотренные ст. 264.1 УК РФ. Раскрыта сущность административной преюдиции указанного деяния. Определены отличительные признаки преступлений, предусмотренных первой и второй частями указанной статьи. Определены особенности, отграничивающие преступление от административного правонарушения. Последовательно рассмотрены объект, объективная сторона, субъект и субъективная сторона указанных общественно опасных деяний. Определены особенности элементов состава преступления в случае совершения осужденными к лишению права занимать определенные должности или заниматься определенной деятельностью.
The article is devoted to the study of repeated crimes related to evasive behavior committed by persons sentenced to deprivation of the right to hold certain positions or engage in certain activities. Based on the statistical data of the Federal Penitentiary Service of Russia, it has been established that the crimes provided for in Article 264.1 of the Criminal Code of the Russian Federation are committed most often by convicts of the category under consideration. The essence of the administrative prejudice of the specified act is studied. The distinctive features of the crimes provided for in parts 1 and 2 of this article are determined. The features distinguishing the crime from the administrative offense are determined. An object, objective side, subject and subjective side of these socially dangerous acts are consistently considered. The features of the corpus delicti elements are determined in the case of the convicted persons being deprived of the right to hold certain positions or engage in certain activities.
Patriotism as a Necessary Element of Professional Legal Awareness of a Law Enforcement Officer
Authors: Крюков А.Н. , Лапенков Е.О. 
Published: December 2022

Настоящая статья посвящена исследованию понятия «патриотизм» как элемента профессионального правосознания сотрудника правоохранительных органов, его толкованию и значению, а также вопросам содержания патриотического воспитания и его особенностям применительно к правоохранительным органам. В статье формулируются предложения по организации патриотического воспитания с учетом внешних негативных факторов, а также рисков деформации профессионального правосознания и правовой культуры сотрудника правоохранительных органов.
This article discusses the concept “patriotism” as an element of professional legal awareness of a law enforcement officer, its interpretation and meaning, as well as the content of patriotic education and its features in relation to law enforcement agencies. The article formulates proposals for organizing patriotic education with regard to external negative factors, as well as risks of deformation of professional legal awareness and legal culture of a law enforcement officer.
Penal System Philosophy as the Factor to Maintain Its Stability (Metatheoretical Aspects)
Authors: Лапшин В.Е. , Шаханов В.В. 
Published: December 2022

Стабильность любой системы определяется не только разработанностью ее теоретической компоненты. Важным системообразующим фактором является метатеория, располагающая широким спектром инструментальных возможностей для познания объектной теории. Этот инструментарий включает средства теоретического и философского уровней. Использование последних для уголовно-исполнительной системы особенно актуально в условиях отсутствия у многих ее сотрудников уголовно-правового мировоззрения и комплексного юридического мышления. Выход из этой ситуации невозможен без освоения философского уровня знания об уголовно-исполнительном праве. Философия уголовно-исполнительного права является метафеноменальной основой уголовно-исполнительной системы. Внедрение философских начал в уголовно-исполнительную систему позволит сохранить стабильность, повысив внутреннюю и внешнюю устойчивость в условиях кризиса религии и морали. Ее инструментарий даст возможность сотрудникам, работникам и осужденным приобретать способность сознательно обращать внимание на свои мысли, эмоции и поведение, оценивать принятые решения и перспективы.
The stability of any system is determined not only by the development of its theoretical component. An important system-forming factor is the metatheory, which has a wide range of instrumental possibilities for cognizing the object theory. This toolkit includes tools of theoretical and philosophical level. The use of the latter is especially relevant for the penal system, since many its employees lack a criminal law worldview and complex legal thinking. The way out of this situation is impossible without mastering the philosophical level of knowledge about penal law. The penal law philosophy is a metaphenomenal basis of the penal system. The introduction of philosophical principles into the penal system will help maintain stability, increasing internal and external stability in the context of religion and morality crisis. Its tools will enable employees, workers and convicts to acquire the ability to consciously pay attention to their thoughts, emotions and behavior, evaluate decisions and prospects.
On Some Issues of Implementing Constitutional Principles in the Public Administration Mechanism in Modern Russia
Authors: Нагорных Р.В. , Вологдин А.И. 
Published: December 2022

Конституционные принципы определяют основу организации публичной власти в нашей стране и позволяют создать необходимые условия для реализации демократических начал публичного управления. Конституция Российской Федерации и действующее законодательство определяют особенности функционирования органов публичной власти. В этой связи основной целью работы является рассмотрение системы конституционных принципов, их роли, значения и порядка реализации в публичном управлении. Авторы статьи обосновывают вывод о том, что процесс совершенствования конституционного и административно-правового регулирования публичного управления находится в стадии непрерывного развития, что обусловливает необходимость повышенного внимания к решению задач фактической реализации конституционных принципов в действующем законодательстве, подзаконных нормативных актах и актах административно-правового управления.
Constitutional principles define the basis for organizing public authorities in our country and ensure creation of necessary conditions for the implementation of democratic principles of public administration. The Constitution of the Russian Federationand the current legislation determine the specifics of public authorities functioning. In this regard, the main purpose of the work is to consider the system of constitutional principles, their role, significance and order of implementation in public administration. The article authors substantiate the conclusion that the process to improve the constitutional and administrative-legal regulation of public administration is constantly developing. Hence, increased attention should be paid to solving problems of actual implementation of constitutional principles in the current legislation, subordinate regulations and administrative management acts.
Legal Regulation and Organization of Educational Work with Convicts Put On Preventive Registration (Case Study of the Correctional Facility No. 2 of the Federal Penitentiary Service of Russia in the Vologda Oblast)
Authors: Дербина О.В. , Иванова А.А. 
Published: December 2022

В статье раскрываются понятие, значение и основания постановки на профилактический учет. Указываются особенности воспитательной работы с осужденными данной категории. Приведен положительный опыт работы в данном направлении ФКУ ИК-2 УФСИН России по Вологодской области. Обозначены отдельные проблемы организации воспитательной работы с осужденными, состоящими на профилактическом учете: недостатки в правовом обеспечении профилактического учета осужденных, невозможность индивидуализировать профилактическую работу в условиях большого количества профилактируемых лиц и некомплекта персонала, недостаточный уровень психологической и педагогической подготовки сотрудников, осуществляющих психологическое сопровождение воспитательной работы с разными категориями осужденных, состоящими на профилактическом учете
The article presents the concept and meaning of preventive registration, as well as grounds for putting on preventive registration. It describes features of educational work with convicts who are on preventive registration and gives examples of experience in the correctional facility No. 2 of the Federal Penitentiary Service of Russia in the Vologda Oblast. The authors reveal certain problems to organize educational work with convicts who are on preventive registration: shortcomings in the legal provision of preventive registration of convicts, inability to individualize preventive work in conditions of a large number of persons put on prevention and a shortage of personnel, insufficient level of psychological and pedagogical training of employees who carry out psychological support of educational work with different categories of convicts who are on preventive registration.
Features of Public Relations in the Sphere of Entrepreneurial Activity as a Criminal Law Protection Object
Authors: Зворыкин В.В. 
Published: December 2022

Статья посвящена изучению особенностей общественных отношений в сфере предпринимательской деятельности как объекта уголовно-правовой охраны. Автором сделан вывод о том, что сфера предпринимательской деятельности представляет собой сложный и динамичный объект уголовно-правовой охраны, обусловленный спецификой общественных отношений, которые возникают в связи с установленным порядком осуществления самостоятельной, осуществляемой на свой страх и риск деятельности, направленной на систематическое и стабильное получение прибыли, достижение иной личной выгоды и общественной пользы.
The article is devoted to the study of the specifics of public relations in the field of entrepreneurship as an object of criminal law protection. The author concludes that the sphere of entrepreneurial activity is a complex and dynamic object of criminal law protection, due to the specifics of public relations that arise in connection with the established procedure for implementing independent activities aimed at achieving systematic and stable profit, other personal benefits and common wealth.
Public Control in Penal Institutions: Some Issues of Legislation and Implementation Practice Natal’ya S. Maloletkina
Authors: Малолеткина Н.С. , Каменева И.М. 
Published: December 2022

В статье рассматриваются основы регулирования осуществления общественного контроля в учреждениях уголовно-исполнительной системы, практика его применения и результаты анкетирования сотрудников уголовно-исполнительной системы и осужденных, в результате чего выявляется ряд теоретических, нормативных и практических проблем его реализации, особенно с учетом наличия пандемии коронавируса. Предлагается внести изменения в ст. 12 Федерального закона Российской Федерации от 10.06.2008 № 76-ФЗ «Об общественном контроле за обеспечением прав человека в местах принудительного содержания и о содействии лицам, находящимся в местах принудительного содержания» и ст. 85 Уголовно-исполнительного кодекса Российской Федерации. Кроме того, рассматривается ряд практических аспектов повышения эффективности общественного контроля за соблюдением прав содержащихся лиц, в том числе путем взаимодействия общественных наблюдательных комиссий с учреждениями уголовно-исполнительной системы через систему видео-конференц-связи.
The article discusses fundamentals of regulating the implementation of public control in penal institutions, practice of its application and results of the survey of the penal system employees and convicts, as a result of which a number of theoretical, regulatory and practical problems of its implementation are identified, especially taking into account the presence of the coronavirus pandemic. It is proposed to amend Article 12 of the Federal Law of the Russian Federation No. 76-FZ of June 10, 2008 “On public control over ensuring human rights in places of forced detention and on assistance to persons in places of forced detention” and Article 85 of the Penal Code of the Russian Federation. In addition, a number of practical aspects of improving the effectiveness of public control over the observance of detainees’ rights are considered, including through the interaction of public monitoring commissions with penitentiary institutions through a video conferencing system