bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential of Nyamplung Seed Oil (Calophyluminophyllum L.) as a Source of Natural Antioxidants
Authors: Fitriyana Liya , Dani Supardan Muhammad , Aisyah Yuliani , Irfan Irfan 
Published: December 2022

Indonesia has many plants that have the potential as raw materials for medicines and cosmetics, one of which is Calophylluminophyllum which in Indonesian is called the Nyamplung plant. Nyamplung seeds have a high oil content of 73% and have the potential as a source of active compounds. In this study, we looked at the content of active compounds as antioxidants from Nyamplung seed oil produced from the press and press process with degumming. The resulting Nyamplung seed oil contains compounds from the phenolic and steroid groups. Component analysis showed that Nyamplung seed oil contained as many as 20-25 compounds with the highest content being cis-13-Octadecenoic acid, Octadecanoic acid, n-Hexadecanoic acid, cis-Vaccenic acid. Nyamplung seed oil has potential as a source of antioxidants because it has an IC50 value of 50 µg/mL, namely 41.37 µg/mL for oil from the press process and 46.59 µg/mL for oil from the press process with degumming. Keywords: Nyamplung Seed Oil, Extraction, Degumming, Antioxidants
Demand-responsive Users' Travel Behavior and Satisfaction Analysis in Small Cities
Authors: Jaber Ahmed , Al-Sahili Khaled , Juhász János 
Published: December 2022

This study examines the differences in travel behavior between regular and occasional demand-responsive transport users (public transport users), determines the level of service satisfaction, and identifies the key factors of commuters' preferences of using the demand-responsive transport regularly or occasionally for a small-sized urban area (<50 km2). Data were supplemented through field surveys and by focus group discussions. Binary logistic regression and correlation models were used. It is found that probabilities of irregularity are higher for rural areas, male commuters, short trips, educational trips, low-income groups, and non-direct trips. All users are generally satisfied with the service. The most important factors for occasional users are waiting time, trip cost, and trip duration. On the other hand, regular users pay more attention to cleanliness, safety, and comfort. Scheduling of public transportation lines that serve educational zones and provide accessibility to rural areas are needed to improve the quality and attractiveness of the services.
DAMPAK EKONOMI PANDEMI COVID-19 TERHADAP PELAKU USAHA DI INDONESIA
Authors: Sanjaya Tri Bayu , Rosid Arifin , Ardin Galih 
Published: December 2022

There is a great deal of consensus that in addition to cause adversarial impact on the health sector, Covid-19 pandemic has also caused economic disruption on an unprecendeted scale. However, empirical studies that specifically scrutinise the economic impact of this pandemic in Indonesia are still limited. This study aims to provide a more detailed picture of the economic disruption experienced by Indonesian businesses in the time of the pandemic. Analysing survey data from 12,361 respondents, this paper shows in greater detail the effect of Covid-19 shocks on sales, operating expenses, business capacity, business operational difficulties and status, including marketing and labor-related strategies taken by businesses to maintain their business activities. This study also further analyses the implications of variations in the relationship between business operational difficulties, marketing strategies, and labor-related strategies with the annual turnover and the location of the businesses to show heterogeneity in its impact.

Terdapat konsensus bahwa selain berdampak ke sektor kesehatan, pandemi Covid-19 juga memberikan dampak negatif terhadap ekonomi secara luas. Namun, studi empiris yang secara spesifik membahas dampak ekonomi dari pandemi ini di Indonesia masih terbatas. Studi ini bertujuan untuk memberikan gambaran yang lebih detail mengenai dampak ekonomi yang dialami oleh pelaku usaha di Indonesia selama pandemi. Berdasarkan hasil analisis terhadap data dari 12.361 pelaku usaha, studi ini menunjukkan secara detail perubahan penjualan, beban usaha, penggunaan kapasitas usaha, kesulitan operasional usaha yang dihadapi, status operasional usaha, termasuk strategi penjualan dan strategi terkait tenaga kerja yang diambil oleh pelaku usaha untuk mempertahankan aktivitas usaha. Studi ini juga menganalisis lebih jauh implikasi dari variasi hubungan kesulitan operasional usaha, strategi penjualan, dan strategi terkait tenaga kerja dengan omzet dan lokasi dari pelaku usaha untuk melihat dampaknya yang beragam.
A human surrogate neck for traumatic brain injury research
Authors: Farmer Jon , Mitchell Sean , Sherratt Paul , Miyazaki Yusuke 
Published: December 2022

Properties of the human neck such as range and resistance to motion are considered important determinants of the kinematic response of the head pre, during and post-impact. Mechanical surrogate necks (i.e., anthropomorphic test device necks), have generally been limited to a single anatomical plane of motion and an artificially high resistance to motion. The aim of this study was to present the Loughborough University Surrogate Neck that is representative of the 50th percentile human male neck, developed for motion in and between each of the anatomical planes with inertial and flexural stiffness properties matching those of a passive elastic (i.e., negligible active tension) neck muscle state. The complex intervertebral joints were reduced to three encapsulated ball joints with appropriate locations, orientations and distributed range of motion to precisely position and orientate the head with respect to the torso at the neutral position and end range of motion. A plain bearing sub-assembly was incorporated at the C1-C2 vertebral level to permit 50% of the axial rotation with negligible resistance to motion, as exhibited by humans. Detachable elastomeric elements provided resistance to motion across each ball joint and permit any orientation of the head within the physiological range of motion of the joints. The mass of the surrogate neck (1.62 Kg) was in agreement with the typical human range and similar agreement was found for the principal moments of inertia (Ixx 26.8 kg cm2, Iyy 20.5 kg cm2 and Izz 14.3 kg cm2). Quasi-static bending moment and dynamic torque tests characterised the surrogate neck in flexion/extension, lateral flexion and axial rotation. With respect to commercial surrogate necks, the surrogate neck presented here was in closer agreement to the reported human responses, for equivalent loading conditions. The applications of a surrogate neck that can appropriately constrain the head relative to the torso are far reaching in the areas of brain injury mechanism research, and for the development and assessment of protective equipment to reduce the risk of such injuries.
CLIC-01: Manufacture and distribution of non-cryopreserved CAR-T cells for patients with CD19 positive hematologic malignancies
Authors: Kekre Natasha , Hay Kevin A. , Webb John R. , Mallick Ranjeeta , Balasundaram Miruna , Sigrist Mhairi K. , Clement Anne-Marie , Nielsen Julie S. , Quizi Jennifer , Yung Eric , Brown Scott D. , Dreolini Lisa , Waller Daniel D. , Smazynski Julian , Gierc Nicole S. , Loveless Bianca C. , Clark Kayla , Dyer Tyler , Hogg Richard , McCormick Leah , Gignac Michael , Bell Shanti , Chapman D. Maria , Bond David , Yong Siao , Fung Rachel , Lockyer Heather M. , Hodgson Victoria , Murphy Catherine , Subramanian Ana , Wiebe Evelyn , Yoganathan Piriya , Medynski Liana , Vaillan Dominique C. , Black Alice , McDiarmid Sheryl , Kennah Michael , Hamelin Linda , Song Kevin , Narayanan Sujaatha , Rodrigo Judith A. , Dupont Stefany , Hawrysh Terry , Presseau Justin , Thavorn Kednapa , Lalu Manoj M. , Fergusson Dean A. , Bell John C. , Atkins Harold , Nelson Brad H. , Holt Robert A. 
Published: December 2022

Access to commercial CD19 CAR-T cells remains limited even in wealthy countries like Canada due to clinical, logistical, and financial barriers related to centrally manufactured products. We created a non-commercial academic platform for end-to-end manufacturing of CAR-T cells within Canada’s publicly funded healthcare system. We report initial results from a single-arm, open-label study to determine the safety and efficacy of in-house manufactured CD19 CAR-T cells (entitled CLIC-1901) in participants with relapsed/refractory CD19 positive hematologic malignancies. Using a GMP compliant semi-automated, closed process on the Miltenyi Prodigy, T cells were transduced with lentiviral vector bearing a 4-1BB anti-CD19 CAR transgene and expanded. Participants underwent lymphodepletion with fludarabine and cyclophosphamide, followed by infusion of non-cryopreserved CAR-T cells. Thirty participants with non-Hodgkin’s lymphoma (n=25) or acute lymphoblastic leukemia (n=5) were infused with CLIC-1901: 21 males (70%), median age 66 (range 18-75). Time from enrollment to CLIC-1901 infusion was a median of 20 days (range 15-48). The median CLIC-1901 dose infused was 2.3 × 106 CAR-T cells/kg (range 0.13-3.6 × 106/kg). Toxicity included ≥ grade 3 cytokine release syndrome (n=2) and neurotoxicity (n=1). Median follow-up was 6.5 months. Overall response rate at day 28 was 76.7%. Median progression-free and overall survival was 6 months (95%CI 3-not estimable) and 11 months (95% 6.6-not estimable), respectively. This is the first trial of in-house manufactured CAR-T cells in Canada and demonstrates that administering fresh CLIC-1901 product is fast, safe, and efficacious. Our experience may provide helpful guidance for other jurisdictions seeking to create feasible and sustainable CAR-T cell programs in research-oriented yet resource-constrained settings.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03765177, identifier NCT03765177.
A solution for autonomous, adaptive monitoring of coastal ocean ecosystems: Integrating ocean robots and operational forecasts
Authors: Ford David A. , Grossberg Shenan , Rinaldi Gianmario , Menon Prathyush P. , Palmer Matthew R. , Skákala Jozef , Smyth Tim , Williams Charlotte A. J. , Lorenzo Lopez Alvaro , Ciavatta Stefano 
Published: December 2022

This study presents a proof-of-concept for a fully automated and adaptive observing system for coastal ocean ecosystems. Such systems present a viable future observational framework for oceanography, reducing the cost and carbon footprint of marine research. An autonomous ocean robot (an ocean glider) was deployed for 11 weeks in the western English Channel and navigated by exchanging information with operational forecasting models. It aimed to track the onset and development of the spring phytoplankton bloom in 2021. A stochastic prediction model combined the real-time glider data with forecasts from an operational numerical model, which in turn assimilated the glider observations and other environmental data, to create high-resolution probabilistic predictions of phytoplankton and its chlorophyll signature. A series of waypoints were calculated at regular time intervals, to navigate the glider to where the phytoplankton bloom was most likely to be found. The glider successfully tracked the spring bloom at unprecedented temporal resolution, and the adaptive sampling strategy was shown to be feasible in an operational context. Assimilating the real-time glider data clearly improved operational biogeochemical forecasts when validated against independent observations at a nearby time series station, with a smaller impact at a more distant neighboring station. Remaining issues to be addressed were identified, for instance relating to quality control of near-real time data, accounting for differences between remote sensing and in situ observations, and extension to larger geographic domains. Based on these, recommendations are made for the development of future smart observing systems.
Comparative experiment of steel bar corrosion at concrete construction joints
Authors: Huang Guohua , Wu Binzhong , Shen Yin , Wang Li , Li Guoping 
Published: December 2022

Introduction: Construction joint is common and even inevitable in most of the reinforcement concrete structures. This study was to assess the effect of construction joints on chloride-induced corrosion of reinforcing steel in concrete.Methods: Test parameters included two environmental conditions (salt solution immersion condition and cyclic wet-dry condition), two forms of construction joint (direct wet joint and roughened wet joint) and four types of steel bar (mild steel bar, ferritic stainless-steel bar, austenitic-ferritic stainless-steel bar and epoxy-coated steel bar). The corrosion test of 90 specimens was carried out by electrochemical accelerated corrosion method. The weight loss of each steel bar and steel bar section in specimens was measured. An influence coefficient (k_j) of construction joint on local weigh loss of steel bars was defined.Results: Except for epoxy-coated steel bars, the most severe corrosion of experimental steel bars in concrete specimens all occurred at the joints, while the corrosion in non-joint sections of steel bars was relatively uniform and less. The weight loss rate of specimens has the range of 1.18% to 15.73% with an average value of 6.22%. The average k_j of mild steel bars, S11203 stainless steel bars, and S23043 stainless steel bars are 1.38, 1.92, and 1.97, respectively. The average k_j of specimens in immersion condition and cyclic wet-dry condition are 1.44 and 2.07. The corrosion of epoxy-coated steel bars mainly occurred at the damage locations of epoxy coating, not mainly at the joints.Conclusion: Chloride-induced corrosion of steel bars at construction joints was always more severe than at non-joints, especially in cyclic wet-dry environments, even for stainless-steel bar, but epoxy-coated steel bars were excluded.
A diagnostic model for serious COVID-19 infection among older adults in Shanghai during the Omicron wave
Authors: Bao Suxia , Lu Guanzhu , Kang Yaoyue , Zhou Yuanyuan , Wang Yuhuan , Yan Lei , Yin Donglin , Bao Yujie , Yuan Xiaoling , Xu Jie 
Published: December 2022

BackgroundThe Omicron variant is characterized by striking infectivity and antibody evasion. The analysis of Omicron variant BA.2 infection risk factors is limited among geriatric individuals and understanding these risk factors would promote improvement in the public health system and reduction in mortality. Therefore, our research investigated BA.2 infection risk factors for discriminating severe/critical from mild/moderate geriatric patients.MethodsBaseline characteristics of enrolled geriatric patients (aged over 60 years) with Omicron infections were analyzed. A logistic regression analysis was conducted to evaluate factors correlated with severe/critical patients. A receiver operating characteristic (ROC) curve was constructed for predicting variables to discriminate mild/moderate patients from severe/critical patients.ResultsA total of 595 geriatric patients older than 60 years were enrolled in this study. Lymphocyte subset levels were significantly decreased, and white blood cells (WBCs) and D-dimer levels were significantly increased with disease progression from a mild/moderate state to a severe/critical state. Univariate and multivariate logistic regression analyses identified a panel of WBCs, CD4+ T cell, and D-dimer values that were correlated with good diagnostic accuracy for discriminating mild/moderate patients from severe/critical patients with an area under the curve of 0.962.ConclusionSome key baseline laboratory indicators change with disease development. A panel was identified for discriminating mild/moderate patients from severe/critical patients, suggesting that the panel could serve as a potential biomarker to enable physicians to provide timely medical services in clinical practice.
Rapid, accurate, and novel diagnostic technique for respiratory pathogens: Clinical application of loop-mediated isothermal amplification assay in older patients with pneumonia, a multicenter prospective observational study
Authors: Wei Shanchen , Wang Lina , Shi Mingwei , Li Jun , Sun Chunping , Liu Yingying , Zhang Zhi , Wu Yiqun , Huang Lei , Tang Fei , Lv Liping , Mu Xiangdong , Tian Wei , Lin Caiwei , Lu Jianrong , Sun Baojun , Dai Bin , Xiong Hui , Nie Xiuhong , Ding Weimin , Ouyang Yuqing , Lin Lianjun , Liu Xinmin 
Published: December 2022

BackgroundLoop-mediated isothermal amplification (LAMP) is a novel nucleic acid amplification method using only one type of enzyme that can amplify DNA with high specificity, efficiency and rapidity under isothermal conditions. Chips for Complicated Infection Detection (CCID) is based on LAMP. This study translate CCID into clinical application and evaluate its diagnostic value for pneumonia.MethodsEighty one older patients with pneumonia were prospectively enrolled from January 1 to July 23, 2021, and 57 sputum/airway secretion and 35 bronchoalveolar lavage fluid samples were collected and analyzed by CCID and conventional microbiological tests (CMTs). Samples were collected, transported, monitored, and managed by a multidisciplinary team using a sample management information system.ResultsCCID turnaround time was 50 min, and the detection limit was 500 copies/reaction. The percentage of positive samples was significantly higher using CCID than CMTs, especially for Klebsiella pneumoniae (odds ratio [OR], 9.0; 95% confidence interval [CI], 1.1–70.5; p &lt; 0.05), Enterococcus faecalis (OR, ∞; p &lt; 0.01), Stenotrophomonas maltophilia (OR, ∞; p &lt; 0.01), fungi (OR, 26.0; 95% CI, 3.6–190.0; p &lt; 0.01), and viruses (CCID only; p &lt; 0.01). In addition, the percentage of positive results was significantly higher using CCID than CMTs in patients who used antibiotics for more than 3 days (91.9% vs. 64.9%; p &lt; 0.01). Analyzing clinical impact, 55 cases (59.8%) benefited from CCID.ConclusionCCID allows the rapid and accurate detection of pneumonia in older patients. Moreover, this technique is less affected by previous antibiotic treatment and can improve patient care.
The effects of antioxidants on knee osteoarthritis: A systematic review and meta-analysis
Authors: Nejadhosseinian Mohammad , Djalalinia Shirin , Haerian Hoda , Alikhani Majid , Mansour Asieh , Mousavian Amir-Hossein , Mardani-Fard Heydar Ali , Kasaeian Amir , Faezi Seyedeh Tahereh 
Published: December 2022

ObjectiveKnee osteoarthritis (KOA) is one of the growing health problems with a considerable burden. With recent research on the possible effectiveness of antioxidants in the remission of KOA symptoms, a systematic review and meta-analysis was required to confirm this hypothesis.DesignLiterature studies were searched on the most comprehensive databases such as PubMed, International Scientific Indexing, and Scopus, with no language and time restrictions. On 17 July 2021, a search strategy was developed based on the roots of “osteoarthritis (OA)” and “antioxidants,” with no time or language limitations. As the primary outcome, pain was evaluated based on all indicators for evaluating pain [e.g., Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores, the visual analog scale (VAS), and the numerical rating scale (NRS)]. The symptoms and functions of KOA and quality of life (QOL) were also considered as secondary outcomes, each of which was measured and reported by the corresponding instrument in the studies. To measure the changes in pain, symptoms, and functions of participants, we included randomized controlled trials with a placebo control or other medical therapeutic interventions. Publication bias was assessed using Begg's funnel plot and Egger's regression test, which was deemed to be statistically significant at 0.1, and the results were checked by the trim-and-fill test.ResultsAfter refinement, data were extracted from 31 documents from 7,698 primary searched papers. Using the VAS as a reliable psychometric measuring instrument, the present study revealed that a significant difference in the characteristics of disease-related symptoms of patients with KOA was reached after antioxidant therapy (standardized mean difference (SMD): 0.467, 95% confidence interval (CI): 0.303–0.632, p &lt; 0.0001). The results reported by WOMAC confirmed no significant difference in the combined score, difficulty score, pain score, and stiffness score.ConclusionAs the first comprehensive systematic review of the association between antioxidant supplementation and KOA, this study showed that antioxidants can decrease disease-related symptoms in patients with KOA. The results can be useful for health policy decisions and future related studies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022351060, identifier: CRD42022351060.
Health economic impacts associated with the consumption of sugar-sweetened beverages in Brazil
Authors: Leal Joice Silva Vieira , Fogal Aline Siqueira , Meireles Adriana Lúcia , Cardoso Letícia de Oliveira , Machado Ísis Eloah , Menezes Mariana Carvalho de 
Published: December 2022

IntroductionThe consumption of sugar-sweetened beverages (SSBs) is among the main risk factors for non-communicable diseases (NCDs). This study aimed to estimate the financial costs of hospitalizations and procedures of high and medium complexity for NCDs attributable to the consumption of SSBs in the Brazilian Unified Health System (SUS) in 2019.MethodsThis ecological study used data from the Global Burden of Disease (GBD) 2019 and the Department of Informatics of the Unified Health System (DATASUS). The attributable costs were estimated from the population-attributable fraction (PAF) and the costs in the treatment of chronic diseases [type 2 diabetes mellitus and ischemic heart disease (IHD)], stratified by sex, age group, level of complexity of treatment, and federative units.ResultsIn 2019, in Brazil, US$ 14,116,240.55 were the costs of hospitalizations and procedures of high and medium complexity in the treatment of NCDs attributable to the consumption of SSBs. These values were higher in males (US$ 8,469,265.14) and the southeast and southern regions, mainly in the state of São Paulo. However, when evaluating these results at a rate per 10,000 inhabitants, it was observed that the states of Paraná, Tocantins, and Roraima had higher costs per 10,000 inhabitants. Regarding the age groups, higher costs were observed in the older age groups.ConclusionThis study revealed the high financial impact of the NCDs treatment attributed to the consumption of SSBs in Brazil and the variability among Brazilian macro-regions. The results demonstrate the urgency and need for the expansion of policies to reduce the consumption of SSBs in Brazil with strategies that consider regional particularities.