bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serotonin syndrome: a rare undiagnosed cause of hyperpyrexia
Authors: Ibrahim Hamdy , Maksod Safwat Abdel , Khorshed Magdy , Rady Hanan , Alsisi Ahmed , Mohamed Adel , Alkassas Omar , Haron Marwa , Saied Suzan 
Published: June 2023

AbstractSerotonin syndrome (SS) is a rare but potentially life-threatening condition, and it is caused by
increasing serotonergic activities. It is an underdiagnosed and under-reported
condition. Clinical manifestations can range from mild to moderate to severe
symptoms. The intensity of symptoms reflects the degree of serotonin toxicity, and
mild serotonin syndrome is easily overlooked by physicians.Severe serotonin
toxicity typically occurs to a combination of serotonergic agents.Herein, we describe a
case of severe serotonin toxicity in a 38-year-old Egyptian male with a history
of generalized anxiety disorder and depression. With increased depressive
symptoms, he received 20 mg of fluoxetine daily, and the symptoms
developed 1 month after starting fluoxetine, which is the uncommon onset
of presentation. The patient was already on tramadol for chronic low backache. The
aim is to increase awareness of the syndrome among physicians and
neuropsychiatrists.
Pediatric Acute Lymphoblastic Leukemia: Clinical Characteristics, Treatment Outcomes, and Prognostic Factors: 10 Years' Experience From a Low- and Middle-Income Country
Authors: Ahmad Ishfaq , Ghafoor Tariq , Ullah Anwar , Naz Shaista , Tahir Muhammad , Ahmed Shakeel , Arshad Awais , Ali Asghar , Khattack Tariq Azam , Batool Fatima 
Published: June 2023

PURPOSEAcute lymphoblastic leukemia (ALL) represents around 70% of pediatric leukemia. In high-income countries, the 5-year survival is above 90%, but survival in low- and middle-income countries is inferior. This study documents the treatment outcome and prognostic factors of pediatric ALL in Pakistan.MATERIALS AND METHODSIn this prospective cohort study, all newly diagnosed patients with ALL/lymphoblastic lymphoma from age 1 to 16 years enrolled between January 1, 2012, and December 31, 2021, were included. The treatment was based on the standard arm of the UKALL2011 protocol.RESULTSData from 945 patients with ALL, including 597 males (63.2%), were analyzed. The mean age at diagnosis was 5.73 ± 3.51 years. Pallor was the commonest presentation in 95.2% followed by fever in 84.2% of patients. The mean WBC count was 56.6 ± 103.4 × 109/L. Neutropenic fever followed by myopathy was the most common complication during induction. In univariate analysis, the high WBC count ( P ≤ 0.001), intensive chemotherapy ( P ≤ 0.001), malnutrition ( P = .007), poor response to induction chemotherapy ( P = .001), delayed presentation ( P = .004), and use of steroids before chemotherapy ( P = .023) significantly adversely affected overall survival (OS). The delayed presentation was the most significant prognostic factor in the multivariate analysis ( P ≤ .002). After a median follow-up of 54.64 ± 33.80 months, the 5-year OS and disease-free survival (DFS) were 69.9% and 67.8%, respectively.CONCLUSIONIn this largest cohort of childhood ALL from Pakistan, a high WBC count, malnutrition, delayed presentation, previous steroids use, intensive chemotherapy, and poor response to the induction chemotherapy were associated with decreased OS and DFS rates.
Screening and Prevention of Type 1 Diabetes: Where Are We?
Authors: Simmons Kimber M , Sims Emily K 
Published: June 2023

Abstract
A diagnosis of type 1 diabetes (T1D) and the subsequent requirement for exogenous insulin treatment is associated with considerable acute and chronic morbidity and a substantial effect on patient quality of life. Importantly, a large body of work suggests that early identification of presymptomatic T1D can accurately predict clinical disease, and when paired with education and monitoring, can yield improved health outcomes. Furthermore, a growing cadre of effective disease-modifying therapies provides the potential to alter the natural history of early stages of T1D. In this mini review, we highlight prior work that has led to the current landscape of T1D screening and prevention, as well as challenges and next steps moving into the future of these rapidly evolving areas of patient care.
Hyperthyroidism Due to Graves Disease After Radiofrequency Ablation
Authors: McAninch Elizabeth A , Desai Kaniksha , McCowen Karen C , Orloff Lisa A 
Published: June 2023

Abstract
Management options for benign, autonomously functioning, and malignant thyroid nodules were limited to surgery or targeting by radioactive iodine before the availability of radiofrequency ablation (RFA). Despite being a relatively new technique, RFA may be favored for patients of high surgical risk, and for those who wish to avoid hypothyroidism. Although insurance coverage for the procedure can be a significant barrier, several groups of investigators have shown improved quality of life for RFA compared to surgery, due to the less invasive nature and favorable risk profile. Hyperthyroidism due to transient thyroiditis is a known risk of RFA, secondary to direct trauma and subsequent thyroid hormone release. Here we present a case of an adult with large, symptomatic, multinodular goiter, with no prior history of thyroid autoimmunity, who underwent RFA with successful volume reduction of two nodules, but who developed acute hyperthyroidism due to Graves disease eight weeks after RFA. Larger studies evaluating the risks of RFA should evaluate for incident hyperthyroidism, specifically for Graves disease/thyroid autoimmunity, as this could represent an additional risk of the procedure.
Treatment of Homozygous Familial Hypercholesterolemia With ANGPTL3 Inhibitor, Evinacumab
Authors: Shamsudeen Isabel , McCrindle Brian W , Hegele Robert A 
Published: June 2023

Abstract
Homozygous familial hypercholesterolemia (HoFH) is an ultra-rare, life-threatening, genetic condition characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C). Standard lipid-lowering therapies minimally reduce LDL-C in these patients, and lifelong serial apheresis is the mainstay of treatment. Evinacumab is a monoclonal antibody against angiopoietin-like protein 3 that lowers LDL-C levels via a novel LDL receptor–independent mechanism, and is US Food and Drug Administration approved for HoFH in the United States. We present a pediatric HoFH patient from Ontario who has been receiving evinacumab through special access from Health Canada. A 17-year-old boy was diagnosed with severe HoFH due to compound heterozygous LDLR pathogenic variants. Treatment has included a statin, ezetimibe, and LDL apheresis every 2 weeks, with minimal overall effect on LDL-C levels. He remains asymptomatic from a cardiovascular perspective. At age 16, evinacumab infused intravenously every 4 weeks was added to his treatment. After 12 months, his time-averaged LDL-C decreased by 53.4% from 8.75 mmol/L (338.4 mg/dL) to 4.08 mmol/L (157.8 mg/dL), despite reduced frequency of LDL apheresis from biweekly to monthly. He has experienced no adverse events. Overall, treatment has increased quality of life for him and his family. Evinacumab shows great promise for patients with HoFH, a difficult-to-treat and potentially life-threatening condition.
Choice in Ablative Therapies for Thyroid Nodules
Authors: Hu Q Lina , Kuo Jennifer H 
Published: June 2023

Abstract
Ultrasound-guided ablation procedures have been growing in popularity and offer many advantages compared with traditional surgery for thyroid nodules. Many technologies are available, with thermal ablative techniques being the most popular currently though other nonthermal techniques, such as cryoablation and electroporation, are gaining interest. The objective of the present review is to provide an overview of each of the currently available ablative therapies and their applications in various clinical indications.
A Postcritical Approach to Literary Aging Studies: Older Women's Responses to Dimitri Verhulst's NovellaMadame Verona Comes Down the Hill
Authors: Swinnen Aagje 
Published: June 2023

AbstractScholars in literary aging studies typically engage in oppositional readings that reveal the often-hidden age ideologies of texts while addressing points of exit from these ideologies. This form of research is ethical and political in that it aims to clarify cultural meanings of aging and how to negotiate and subvert them in a world characterized by structural and everyday ageism. Inspired by Rita Felski's plea not to go too far in our suspicion toward the hidden meanings of a text and to value uses of literature other than the strictly ideological, this article focuses on the figure of the older lay reader and their reading practices. It presents field work involving a 2017 reading and writing club of women over sixty who responded to the novella Madame Verona Comes Down the Hill (2006) by the Flemish author Dimitri Verhulst. Analyzing the reading diaries, group discussion, and creative writing exercises of the participants will show how these readers draw on both form and ideology when making sense of and coming to terms with the life and death of the main character, an eighty-two-year-old widow who descends from the hill to die and to follow her beloved to the grave.
Kinetic Mass Transfer Behavior of Eu(III) in Nitrilotriacetamide-Impregnated Polymer-Coated Silica Particles
Authors: Miyagawa Akihisa , Hayashi Naoki , Kuzure Yoshiaki , Takahashi Takumi , Iwamoto Hibiki , Arai Tsuyoshi , Nagatomo Shigenori , Miyazaki Yasunori , Hasegawa Kenta , Sano Yuichi , Nakatani Kiyoharu 
Published: June 2023

Abstract
We investigated the distribution mechanism of Eu(III) in a single polymer-coated silica particle including nitrilotriacetamide (NTA) extractants known as HONTA and TOD2EHNTA. We studied the kinetic rate constants of the distribution process at various concentrations of NO3− (CNO3−) that were prepared using HNO3 and NaNO3 solutions. The rate-determining process during the distribution of Eu(III) was identified as the reaction process of Eu(III) for both extractants, that is, the reaction process of Eu(III) and two NTA molecules in the polymer layer of the silica particle. Furthermore, the reaction of Eu(III) with NO3− ions was found not to be involved in the rate-determining process. The forward (k1) and backward (k−1) reaction kinetic constants for the reaction between Eu(III) and two NTA molecules were determined to be k1 = (5.7 ± 2.2) × 102 M−2 s−1 and k−1 = (2.3 ± 4.4) × 10−4 s−1 for HONTA, and k1 = (6.5 ± 3.0) × 102 M−2 s−1 in the NaNO3 system and k−1 = (2.0 ± 1.5) × 10−4 s−1 in both solutions for TOD2EHNTA. The present study provides a valuable approach for the evaluation and enhancement of the functionality of ‘single extractant-impregnated polymer-coated silica particles’.
Exercise Mediates Myokine Release and Tumor Suppression in Prostate Cancer Independent of Androgen Signaling
Authors: Kim Jin-Soo , Taaffe Dennis R. , Galvão Daniel A. , Saad Fred , Newton Robert U. 
Published: June 2023

ABSTRACT
A prominent toxicity of androgen suppression in prostate cancer patients is loss of skeletal muscle. Exercise may induce tumor-suppression through the endocrinal function of skeletal muscle, however, this is currently unknown. In this review we summarise our work demonstrating the acute and chronic myokine response to exercise and the tumor-suppressive effect of circulatory milieu alteration in prostate cancer patients.
Uniwersytet Trzeciego Wieku w obliczu potrzeb „patchworkowo-kolażowej” starości
Authors: Sulik Monika 
Published: June 2023

W artykule została podjęła próba dookreślenia tzw. „nowej” starości, którą autorka nazywa metaforycznie „kolażowo-patchworkową” starością. W kontekście tych rozważań ukazana została rola i znaczenie uniwersytetu trzeciego wieku w realizacji potrzeb współczesnych seniorek i seniorów. Potrzeby te zostały ujęte w sposób wielowymiarowy, przez pryzmat trzech wyróżnionych przez Autorkę dyna- mik: poszukiwanie i poznanie, transformacja i transgresja oraz przemijanie i utrata. Ilustracją podjętych rozważań są zamieszczone w tekście refleksje słuchaczek i słuchaczy Uniwersytetu Trzeciego Wieku w Uniwersytecie Śląskim, w Katowicach.

uniwersytet trzeciego wieku, potrzeby, współczesna starość, nowa starość, kolażowa starość, patchworkowa starość, senior, seniorka.
Executive Compensation Limits and Executive Turnover
Authors: Nanda Vikram , Silveri Sabatino (Dino) , Wang Kun , Zhao Le 
Published: June 2023

We explore the consequences of limiting executive pay on voluntary executive turnover by exploiting a Chinese government policy restricting executive pay at a subset of firms. Affected firms experience an increase in voluntary executive turnover, with executives increasingly moving to firms not bound by the pay policy. Executives that leave are of higher quality as suggested by their stronger stock and accounting performance in the year prior to the turnover. Affected firms suffer firm value losses, especially when talented executives leave. Our findings demonstrate the importance of compensation contracts in retaining executives and suggest a need for regulatory caution, since mandated constraints aimed at trying to “fix” executive pay can hurt firm value and ultimately, hurt shareholders. This paper was accepted by Suraj Srinivasan, accounting. Funding: S. Silveri acknowledges research support in the form of a summer research grant from the Fogelman College of Business and Economics at the University of Memphis. This research support does not imply endorsement of the research results by either Fogelman College or the University of Memphis. K. Wang is grateful for the financial support provided by the Tsinghua University Initiative Scientific Research Program and the research project of the Institute for State-Owned Enterprises, Tsinghua University. L. Zhao is grateful for the financial support provided by the Asia Research Center in Nankai University [Project AS2206]. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023.4812 .
Fiber-optic frequency comb generation using low-seed power FWM and Brillouin-assisted power equalization
Authors: Paul Aritra , Mishra Tanooja , Krishnamurthy Pradeep Kumar 
Published: June 2023

In this paper, we experimentally demonstrate an all-fiber broadband
tunable optical frequency comb (OFC) operating in the C-band. The OFC
is generated by broadening a power-equalized stimulated Brillouin
scattering (SBS)-based seed comb (SBS-OFC) using four-wave mixing
(FWM) in a highly nonlinear fiber (HNLF). The seed SBS-OFC is obtained
from a pump and Stokes power recycling cavity, which yields ≈15 comb lines with 10.8 GHz line
spacing having 16 dBm average power. The seed SBS-OFC is
further power-equalized by a Brillouin-assisted power equalization
(BAPE) technique to minimize the high pump contribution at the
recycling cavity output. The power-equalized seed SBS-OFC, which has
low-power of −4.5dBm at the BAPE cavity output, is
propagated down a dual-pass 200 m dispersion flattened HNLF. At
the HNLF output, we obtain ≈140 comb lines within a 12 nm
bandwidth having 10.8 GHz line spacing. We demonstrate
wavelength tunability over a span of 35 nm by using a tunable
laser source as the Brillouin pump. We also observe and measure a
secondary OFC generated during the power-equalization process by
placing a 10% coupler inside the BAPE cavity. Our experimental results
closely match the trends obtained in the simulation.
Laser energy partitioning in nanosecond pulsed laser-induced air breakdown: effect of incident laser energy
Authors: Qayyum Hamza , Ali Wahaj Aatif , Noor Ayesha , Abdel-Aty Abdel-Haleem , Al-Harbi Nuha , Qayyum Abdul , Rehman Zia Ur 
Published: June 2023

Air breakdown is generated by a 1064 nm nanosecond pulsed laser beam, and laser energy deposited in the breakdown (E
d
), transmitted through the plasma region (E
t
) and carried away by the shock wave (E
s
) is estimated for the incident laser energy (E
i
) range of 60–273 mJ. The E
d
is approximately 85% of E
i
at 60 mJ, rapidly increasing to 92% at 102 mJ. The shock wave front velocity and radius are measured as a function of E
i
and propagation distance. The shock wave velocity nicely follows the v∝E
i
0.3 trend predicted by the laser-supported detonation wave model. The Sedov–Taylor theory is used to estimate E
s
, which rapidly increases with E
i
, but E
i
to E
s
conversion linearly decreases from 83% to 48%. At lower values of E
i
, most of the laser energy is carried away by the shock wave, whereas the laser energy used in plasma heating or released in the form of electromagnetic and thermal radiation becomes important at higher laser energies. This implies that laser energy partitioning is highly dependent on the value of incident laser energy. These findings provide important insights into the fundamental physics of air breakdown and will be useful in a variety of applications such as laser-induced breakdown spectroscopy, laser ignition, and laser propulsion.
Effects of digital cognitive behavioral therapy for depression on suicidal thoughts and behavior: Protocol for a systematic review and meta-analysis of individual participant data
Authors: Sander Lasse Bosse , Beisemann Marie , Karyotaki Eirini , van Ballegooijen Wouter , Cuijpers Pim , Teismann Tobias , Doebler Philipp , Domhardt Matthias , Baumeister Harald , Büscher Rebekka 
Published: June 2023

IntroductionDigital cognitive behavioral therapy (i-CBT) interventions for the treatment of depression have been extensively studied and shown to be effective in the reduction of depressive symptoms. However, little is known about their effects on suicidal thoughts and behaviors (STB). Information on the impact of digital interventions on STB are essential for patients’ safety because most digital interventions are self-help interventions without direct support options in case of a suicidal crisis. Therefore, we aim to conduct a meta-analysis of individual participant data (IPDMA) to investigate the effects of i-CBT interventions for depression on STB and to explore potential effect moderators.MethodsData will be retrieved from an established and annually updated IPD database of randomized controlled trials investigating the effectiveness of i-CBT interventions for depression in adults and adolescents. We will conduct a one-stage and a two-stage IPDMA on the effects of these interventions on STB. All types of control conditions are eligible. STB can be measured using specific scales (e.g., Beck scale suicide, BSS) or single items from depression scales (e.g., item 9 of the PHQ-9) or standardized clinical interviews. Multilevel linear regression will be used for specific scales, and multilevel logistic regression will be used for treatment response or deterioration, operationalized as a change in score by at least one quartile from baseline. Exploratory moderator analyses will be conducted at participant, study, and intervention level. Two independent reviewers will assess the risk of bias using the Cochrane Risk of Bias Tool 2.ConclusionThis IPDMA will harness the available data to assess the effects (response and deterioration) of i-CBT interventions for depression interventions on STB. Information about changes in STB is essential to estimate patients’ safety when engaging in digital treatment formats.Trial registrationWe will pre-register this study with the open science framework after article acceptance to ensure consistency between online registration and the published trial protocol.
Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps
Authors: Chiang Chih-Hsiang , Chang Yu-Jun , He Sin-Ru , Chao Jih-Ning , Yang Chih-Huai , Liu Yen-Tze 
Published: June 2023

Background
Studies have revealed the association of vitamin D with specific types of cancer development, however, its correlation with colorectal polyps (CRPs) remains unverified. Our study aimed to investigate the relationship between vitamin D levels, metabolic factors, and CRPs.

Methods
A cross-sectional study from 2017 to 2019 involving 1306 participants was conducted to investigate the association among vitamin D levels, metabolic factors, uric acid and CRPs in Taiwan. CRPs diagnoses were determined via colonoscopies conducted by experienced gastrointestinal physicians, and biopsied polyps were inspected under a microscope by experienced pathologists. We employed both simple and multiple logistic regression analyses to identify significant factors associated with CRPs and adenomatous polyps, respectively.

Results
Our result showed that the prevalence of 25(OH)-vitamin D deficiency (≦ 20 ng/mL) and CRPs was 21.21% and 40.89%, respectively. Multiple logistic regression revealed that the risk of CRPs increased with old age, male sex, hyperglycemia, high triglyceride levels, and low 25(OH)D levels after adjustment for other factors. Besides, low 25(OH)D levels were significantly associated with CRPs risk in women, whereas elevated blood pressure was associated with CRPs risk in men. 25(OH)D Deficiency was revealed to be significantly associated with risk of CRPs in adults over 50 years old. Compared to nonadenomatous polyps, older age, higher 25(OH) vitamin D and higher uric acid levels were at increased risk for adenomatous polyps.

Conclusions
Our study revealed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women. We should therefore be concerned about the CRP risk of vitamin D deficiency and metabolic syndrome (especially hyperglycemia, elevated blood pressure in men, and high triglyceride levels) in this population.
Does the contribution of modifiable risk factors on oral health inequities differ by experience of negative life events among Indigenous Australian adults?
Authors: Jamieson Lisa , Hedges Joanne , Paradies Yin , Ju Xiangqun 
Published: June 2023

Objective
Although the prevalence of poor self-rated oral health and experience of negative life events among Indigenous adults is high, the contribution of modifiable risk factors is unknown. We aimed to estimate the contribution of modifiable risk factors in poor self-rated oral health among Indigenous Australian adults with high and low experience of negative life events using decomposition analysis.

Methods
The study utilised a cross-sectional design, with data from a large convenience study of Indigenous adults in South Australia. Participants were stratified based on a median split of negative life events in the last 12 months. The outcome was the proportion of fair/poor self-rated oral health (SROH). Independent variables included experience of racism, sex, age, geographic location, car ownership, and time since last dental visit.

Results
Of the 1011 participants, the proportion with fair poor self-rated oral health was 33.5% (95% CI 30.5 to 36.4) and the proportion who had experienced 3+ negative life events in the past 12 months was 47.3% (95% CI 43.7 to 50.9). More than half the contribution in fair/poor self-rated oral health among Indigenous adults with a higher magnitude of negative life events was from experience of racism (55.3%, p<0.001), followed by residential location (19.9%), sex (9.7%) and car ownership (9.8%).

Conclusions
The contributions of modifiable risk factors in poor self-rated oral health among Indigenous adults with different exposures to negative life events differed substantially. Targets to reduce racism will decrease oral health inequities for both groups, however Indigenous adults who have experienced substantial negative life events require additional focus on provision of culturally safe dental care.