bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spindle Condition Monitoring With a Smart Vibration Sensor and an Optimized Deep Neural Network
Authors: Oh Louis , Pitz Emil , Pochiraju Kishore 
Published: January 2023

Abstract
This article presents a spindle condition monitoring methodology using a low-power smart vibration sensor and a near real-time deep neural network (DNN) classifier. The most frequent spindle failures, such as imbalance, ingression, and evidence of a crash with the workpiece, are analyzed in this study. Experiments were designed to induce various failure events to monitor the spindle behavior using conventional vibration, current and temperature sensors, and an intelligent vibration sensor. The smart sensor is a device with internal signal processing identifying eight dominant frequencies and the amplitude/power distributions. It requires low power and generates narrow bandwidth messages that can be communicated wirelessly. A Fog device and a test plan are designed to monitor and store a dataset needed to train a DNN classifier. The Fog device generates temperature, current, and vibration signals from sensors connected to the spindle and sends them to data storage in the cloud. The signals were analyzed using both conventional vibration analysis and Artificial Intelligence-based classifiers. Metrics such as crest factor, skewness, kurtosis, and overall enveloping were used to assess their ability to identify the failure condition. The data from the smart sensor are used to train an optimized DNN, and the spindle defect classification performance is measured. With 960 data points per failure mode and training data taken over 960 min of operation, the optimized DNNs can classify the spindle states with an accuracy of 98%. The study shows real-time spindle condition classification feasibility over long periods using inexpensive and low-power smart vibration sensors.
A Code-to-Code Comparison for Dynamic Modeling and Response Analysis of Offshore Wind Turbine Blade Mating Process
Authors: Bhaskaran Saravanan , Shankar Verma Amrit , Yuan Shuai , Jiang Zhiyu , Henning Halse Karl 
Published: January 2023

AbstractOffshore wind turbine blade installation using jack-up crane vessel is a challenging task. Wave- and wind-induced loads on the installation system can cause large relative motion between the blade root and the hub during the mating process. Currently, several numerical tools are used to analyze such critical global motion responses; however, the industry suffers from lack of experiments and full-scale measurements to validate the accuracy of these results. Consequently, a code-to-code comparison exercise becomes critical as it allows comparing different numerical tools for reliable prediction and verification of results. In the present article, a numerical model of the offshore wind turbine blade mating process using a jack-up crane vessel is developed in orcaflex, and a code-to-code comparison is performed against sima; both these tools are immensely used in the industry for modeling marine operations. Different comparisons are made between both the tools such as: (1) modal analyses of the jack-up vessel and the blade lifting gear, (2) time-domain analysis of the fully coupled installation vessel-crane-blade system, and (3) a comprehensive sensitivity study based on different seed numbers and simulation periods. The results of the study show a good agreement between both the tools with a deviation of less than 3% in terms of modal analysis and less than 5% variation in time-domain results. Further, the article provides modeling guidelines for the industry practitioners that heavily rely on both the tools for modeling marine operations.
Simulated Experimental Assessment of a Laboratory-Scale Solar Convective Furnace System
Authors: Kumar Vishwa Deepak , Chandra Laltu , Mukhopadhyay Sudipto , Shekhar Rajiv 
Published: January 2023

Abstract
Electricity and gas-based heat treatment of metal is an energy-intensive process. To mitigate the use of such high-grade energy, the concept of an open volumetric air receiver-based solar convective furnace (SCF) system is developed for the heat treatment of metal. This system includes an in situ waste heat recovery mechanism. This paper presents a Joule heating-based, controlled, experimental assessment of a laboratory-scale, retrofitted, SCF system for generating benchmark data. The reported measurements illustrate the heat transfer for (a) the charging and discharging process of thermal energy storage and (b) the two-stage heat treatment of metal with an in situ heat recovery process. The overall system efficiency, including heat recovery, heat storage, and heat transfer, is found to be 24%. Thus, the SCF system can serve as a viable alternative to an electrical energy-based heat treatment furnace.
Oilstone Processing and Its Impact on the Surface Texture of Cylinder Bore
Authors: Zhang Xin , Liu Xijuan , Zhang Xueping 
Published: January 2023

AbstractHoning is one of the abrasive-based machining processes to remove material through the asperity interaction between numerous stochastic grains distributed on oilstone (also called honing stone) and workpiece. Therefore, the oilstone surface topography characterized by grain morphology, size, posture and position distribution, protrusion heights and etc. is of great significance to understand honing mechanism in terms of establishing an accurate kinematic model and further analyzing the oilstone property's impact on honing process and honed surface texture characteristics including groove density, roughness heights, and plateau/valley amplitudes. Conventionally, two typical approaches have been employed to establish the surface topography of abrasive-based cutting tools: experimentally microscopic observation and backward modeling/simulation from the assumed ideal distribution laws such as Gaussian or uniform distribution for stochastic grain characteristics. The first method is usually time-consuming and only measures surface topography within rather small area, whereas the second one is highly dependent on the authenticity of assumed statistical distribution laws. To overcome these weaknesses, the research proposed a functional forward method (FFM) to accurately predict surface topography of oilstone based on simulating its manufacturing processes in succession to avoid distributional assumptions and geometrical simplification. The methodology takes into consideration five important stochastic characteristics of oilstone including grain morphology, size, posture, position distribution, and grain wear during honing process, to guarantee the credibility, authenticity, and generality of the surface topography generated from honing. Based on the oilstone surface topography, the kinematic simulation method (KISM) was applied to analyze the honed surface texture characteristics of cylinder bore with oilstone samples under different stirring times. Therefore, the methodology bridges oilstone manufacturing parameters, oilstone surface topography, and further the honed surface texture to provide a fresh insight into the parameter’s optimization of the oilstone manufacturing process by achieving a better control on the honed surface texture of the cylinder bore.
YAP-Activated SATB2 Is a Coactivator of NRF2 That Amplifies Antioxidative Capacity and Promotes Tumor Progression in Renal Cell Carcinoma
Authors: Jin Juan , Chen Fen , He Wenfang , Zhao Li , Lin Bo , Zheng Danna , Chen Li , He Hongchao , He Qiang 
Published: January 2023

AbstractAberrant epigenetic reprogramming contributes to the progression of renal cell carcinoma (RCC). Elucidation of key regulators of epigenetic reprogramming in RCC could help identify therapeutic vulnerabilities to improve treatment. Here, we report upregulation of the nuclear matrix-associated protein, special AT-rich binding protein-2 (SATB2), in RCC samples, which correlated with poor prognosis. SATB2 inhibition suppressed RCC growth and self-renewal capacities. YAP/TEAD4 activated SATB2 expression and depended on SATB2 to enhance cell proliferation. Transcriptome analysis implicated that SATB2 regulates NRF2 downstream targets to suppress oxidative stress without altering NRF2 levels. Integrated chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin using sequencing analyses demonstrated that SATB2 coordinated with NRF2 to drive enhancer–promoter interactions, amplifying transcriptional activity. SATB2 recruited SWI/SNF complex subunits, including BRD7 or BRG1, to sustain DNA accessibility. Increased SATB2 triggered chromatin remodeling into configurations that rendered RCC more sensitive to SATB2 deficiency. Moreover, SATB2 ablation promoted the sensitivity of RCC to chemotherapy-induced apoptosis. Finally, targeting SATB2 or BRD7 effectively restricted the proliferation of YAP-high tumors in patient-derived xenografts and patient-derived organoids. Together, SATB2 is an oncogenic chromatin organizer in RCC, and targeting SATB2 is an effective strategy to suppress the YAP-high RCC.Significance:A YAP-SATB2-NRF2 regulatory axis amplifies antioxidative stress signaling and provides potential therapeutic targets to enhance response to chemotherapy in renal cell carcinoma.
HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype
Authors: Xu Man , Sun Ming , Zhang Xiyuan , Nguyen Rosa , Lei Haiyan , Shern Jack F. , Thiele Carol J. , Liu Zhihui 
Published: January 2023

AbstractNoradrenergic neuroblastoma is characterized by a core transcriptional regulatory circuitry (CRC) comprised of transcription factors (TF) such as PHOX2B, HAND2, and GATA3, which form a network with MYCN. At normal physiologic levels, MYCN mainly binds to promoters but when aberrantly upregulated as in neuroblastoma, MYCN also binds to enhancers. Here, we investigated how MYCN invades enhancers and whether CRC TFs play a role in this process. HAND2 was found to regulate chromatin accessibility and to assist MYCN binding to enhancers. Moreover, HAND2 cooperated with MYCN to compete with nucleosomes to regulate global gene transcription. The cooperative interaction between MYCN and HAND2 could be targeted with an Aurora A kinase inhibitor plus a histone deacetylase inhibitor, resulting in potent downregulation of both MYCN and the CRC TFs and suppression of MYCN-amplified neuroblastoma tumor growth. This study identifies cooperation between MYCN and HAND2 in neuroblastoma and demonstrates that simultaneously targeting MYCN and CRC TFs is an effective way to treat this aggressive pediatric tumor.Significance:HAND2 and MYCN compete with nucleosomes to regulate global gene transcription and to drive a malignant neuroblastoma phenotype.
Stepped Behavioral and Biological Screening for Oral Oncogenic HPV DNA in Middle-aged and Elderly Adults: A Feasibility Study
Authors: Day Andrew T. , Sample Reilly A. , Salley Jordan R. , Oliver Dwight , Dahlstrom Kristina R. , Sturgis Erich M. , Tiro Jasmin A. 
Published: January 2023

Abstract

Novel preventive interventions are needed to address the rising incidence of human papillomavirus (HPV)-mediated oropharyngeal cancer (HPV+ OPC). This pilot study evaluated the feasibility of a stepped, behavioral and biological screening program for oral oncogenic HPV infection, an intermediate HPV+ OPC outcome.

This was a cross-sectional, feasibility study. Eligible 45–74 years old adults identified from three clinical research registries were administered a behavioral risk survey (step 1). Participant tobacco use and sexual behavior history were translated into a quantifiable risk of oral oncogenic HPV DNA, according to prior National Health and Nutrition Examination Survey analyses. Females with &gt;2% risk and males with &gt;7% risk were offered biological screening for oral oncogenic HPV DNA (step 2) via an oral rinse and gargle specimen.

A total of 292 individuals were contacted, but only 144 (49%) were reached. Among these, 56 individuals (19%) were uninterested and 18 (13%) were ineligible. Seventy individuals began the survey and 66 completed it (step 1), among whom 46 were classified as low-risk. Among the remaining 20 participants classified as high-risk for an oral oncogenic HPV infection, 5% were current smokers and the median participant had performed oral sex on 10 unique partners. During step 2 (biological screening), 45% (9/20) completed testing, all of whom tested negative for oral oncogenic HPV DNA.

In this pilot of a stepped, oral oncogenic HPV screening program, enrollment and study completion were suboptimal. These barriers to screening should be characterized and addressed before reevaluating the feasibility of this program.

Prevention Relevance:
Novel preventive interventions are needed to address the rising incidence of HPV+ OPC. In this feasibility study, we characterized barriers to a two-step, behavioral and biological screening program for oral oncogenic HPV infection, an intermediate outcome for HPV+ OPC.
Abstract IA001: Innovation and equity in cancer prevention and screening
Authors: Lowy Douglas R. 
Published: January 2023

Abstract
This presentation will highlight some of the opportunities for improving cancer prevention and screening of asymptomatic individuals, which includes increasing the uptake of current standard of care and research for new interventions that can become standard of care. It is important to strive to address cancer disparities in the US and globally, as the greatest population-wide benefit for current and new interventions will be derived from equitable access to them. To increase the likelihood that uptake of new interventions will be equitable, this parameter should be considered throughout the development and evaluation of the candidate interventions, rather than waiting until after they have been approved. The main goals of prevention and screening are to enable people to live longer healthier lives, and approved interventions should ultimately be held to this standard, although initial approval, especially for primary prevention, may be based on surrogate endpoints. For example, initial HPV vaccine approval, in 2006, was based on its reduction in cervical dysplasia rates. Reduced cancer risk was not observed until more than a decade after that, and the vaccine has still not been formally shown to reduce mortality rates from HPV-associated cancer. The global equitable uptake of the HPV vaccine lags considerably, although the vast majority of HPV-associated cancers occur in low- and middle-income countries. We and others are conducting research to address this important gap. For cancer screening, a much shorter interval is usually needed to determine if the intervention does reduce cancer-specific mortality rates. This parameter is highly relevant for multicancer detection tests, which have considerable potential. While these tests can detect asymptomatic cancer earlier than if one waited for symptoms to develop, it remains to be demonstrated whether cancer detected by this approach will reduce cancer-specific mortality rates. It is also critical to develop equitable approaches for cancer diagnosis and treatment triggered by a positive test.
Citation Format: Douglas R. Lowy. Innovation and equity in cancer prevention and screening. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA001.
Abstract IA014: Precision public health approaches to health equity
Authors: Griffith Derek M. 
Published: January 2023

Abstract
Since President Barack Obama announced the “Precision Medicine Initiative” during his state of the union address in January 2015, the sciences of precision medicine and health equity have largely grown in parallel, though there have been some efforts to bring the two together. As research on health equity has evolved to name and consider structural racism, the penultimate goal of research in this area also as moved from efforts to identify and describe gaps between racial and ethnic groups to characterizing the context creates and perpetuates racial inequities and how best to mitigate them. In this presentation, I will briefly describe how syndemics, intersectionality, and individual tailoring may complement downstream efforts to characterize epigenetic and genomic efforts to develop biomedical interventions to achieve healthcare equity and health equity. After noting how the principles of precision medicine may be applied more broadly than the most common way it is operationalized through genomic medicine, I argue that that creating racial justice in health will require defining health equity more clearly and precisely. Consequently, I utilize the example of Black men and the context of COVID-19 to highlight how more precisely defining the structural context of the population of interest by using tools such as intersectionality and syndemics is fundamental to achieving equity. I highlight how achieving health equity will require creating, resisting, undoing, and mitigating structural racism and note what that means for cancer research. Precision medicine may help to mitigate the health effects of structural racism, and it will remain an important tool to promote population health; however, efforts to achieve health equity and racial justice will require interventions that change the contexts and conditions that create, exacerbate, and perpetuate structural inequities and the racial inequities in health outcomes that they produce and maintain.
Citation Format: Derek M. Griffith. Precision public health approaches to health equity. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA014.
Abstract IA017: Targeting the mTOR pathway for the prevention of triple-negative breast cancer
Authors: Brown Powel H. , Mazumdar Abhijit , Tahaney William , Hill Jamal , Zhang Yun , Ramachandran Sumankalai , Kawedia Jitesh , Qian Jing , Contreras Alejandra , Savage Michelle , Vornik Lana 
Published: January 2023

Abstract
Phase III cancer prevention clinical trials have shown that breast cancer prevention is feasible using anti-estrogen drugs. However, these drugs have not been widely accepted because of concerns about toxicity. In addition, anti-estrogen drugs do not prevent estrogen-negative breast cancers, including the most aggressive form of breast cancer, triple-negative breast cancer (TNBC), that does not express the estrogen receptor (ER), progesterone receptor, or the human epidermal growth factor receptor 2 (HER2). Our laboratory is focused on identifying growth-regulatory molecules that are essential for the growth of TNBCs. For this study, we identified mTOR as an essential growth-regulatory molecule that is highly expressed in TNBCs. We then investigated whether the mTOR inhibitor everolimus can prevent mammary tumors in transgenic mouse models including 4 models of TNBC and one model of ER-negative/HER2-positive breast cancer. Everolimus treatment significantly delayed mammary tumor formation but with a varying degree in all five mouse models. Everolimus treatment for up to 1 year was well tolerated with no observable toxicity. These results suggest that mTOR inhibitors may be promising drugs for the prevention of ER-negative and triple-negative breast cancers in women at risk of these aggressive breast cancers. Grant support: This research was supported by an NCI-PREVENT contract to P. Brown and A. Mazumdar (HHSN261201500018I/HHSN26100006).
Citation Format: Powel H. Brown, Abhijit Mazumdar, William Tahaney, Jamal Hill, Yun Zhang, Sumankalai Ramachandran, Jitesh Kawedia, Jing Qian, Alejandra Contreras, Michelle Savage, Lana Vornik. Targeting the mTOR pathway for the prevention of triple-negative breast cancer. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA017.
Abstract IA021: Contribution of biomarker-based risk profiles to cancer early detection
Authors: Hanash Samir 
Published: January 2023

Abstract
The potential of blood tests for multi-cancer early detection (MCED) to reduce cancer mortality has elicited both optimism and concern about their generalized applicability. Identifying in the general population individuals at increased risk, through the use of biomarkers together with subject characteristics, has the potential to trigger preventive intervention and to improve effectiveness of early detection through a tailored approach to screening based on a personalized risk profile. The contribution of blood-based biomarkers for personalized lung cancer risk assessment will be highlighted.
Citation Format: Samir Hanash. Contribution of biomarker-based risk profiles to cancer early detection. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA021.
Abstract IA025: Rethinking risk assessment in the era of multi-cancer early detection
Authors: Patel Alpa V. 
Published: January 2023

Abstract
Cancer screening is a critical component of cancer control and reducing cancer mortality as it increases the likelihood of identifying cancers earlier when there is a greater opportunity for therapeutic intervention. Current cancer screening tests, such as mammography, focus on detection of a single cancer type, and screening recommendations for these tests are based on risk of that single cancer. Unfortunately, recommended screening tests are available only for a few cancers that collectively account for approximately one-third of cancer-related deaths, leaving opportunity for enhanced screening that would potentially include additional cancer types. Newer technologies that are under development have the potential to reduce the overall cancer burden because they are focused on the early detection of multiple cancers in a single screening test (called multi-cancer early detection, or MCED, tests). Given existing screenings are cancer-specific, the introduction of MCED tests, which simultaneously target detection of several cancers, will require a new approach to risk assessment and screening guidelines development. Specifically, MCED screening guidelines will require that we understand the populations who will most benefit from using MCED tests; identify the risk factors, other than age, that are associated with risk of developing any cancer; and determine the frequency of screening intervals. In this presentation, we will explore strategies for rethinking risk assessment related to MCED tests to begin informing future multi-cancer screening guidelines.
Citation Format: Alpa V. Patel. Rethinking risk assessment in the era of multi-cancer early detection. [abstract]. In: Proceedings of the AACR Special Conference: Precision Prevention, Early Detection, and Interception of Cancer; 2022 Nov 17-19; Austin, TX. Philadelphia (PA): AACR; Can Prev Res 2023;16(1 Suppl): Abstract nr IA025.