bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound as a Useful Tool for a Peripheral Nerve Surgeon: Examples in Clinical Practice
Authors: Aravind Pathik , Tiongco Rafael Felix P. , McNichols Colton H. , Williams Eric H. 
Published: December 2022

Abstract
Background Peripheral nerve surgeons often require additional imaging for examination, diagnostic testing, and preoperative planning. Point-of-care ultrasound (US) is a cost-effective, accessible, and well-established technique that can assist the surgeon in diagnosing and treating select peripheral nerve pathologies. With this knowledge, the properly trained surgeon may perform US-guided nerve blocks to help accurately diagnose and treat causes of neuropathic pain. We offer this paper, not as an exhaustive review, but as a selection of various peripheral nerve pathologies, which the senior author treats, and their associated US examination findings. Our goal is to encourage other peripheral nerve surgeons to incorporate US into their practices.
Methods We provide various cases from our outpatient peripheral nerve clinic demonstrating relevant US anatomy. We also review techniques for US guided nerve blocks with relevant anatomic landmarks.
Results US imaging successfully assisted in identification and injection techniques for various peripheral nerve pathologies in a surgeon's practice. Examples were presented from the neck, trunk, upper extremity, and lower extremity.
Conclusion Our review highlights the use of US by a peripheral nerve surgeon in an outpatient private practice clinic to diagnose and treat select peripheral nerve pathologies. We encourage reconstructive surgeons to add US to their arsenal of diagnostic tools.
Association of Obesity and Surgery Outcomes in Patients with Endometrial Cancer: A Single-Center Analysis
Authors: Ozdemir Savas , Dogan Gul Ozel 
Published: December 2022

Abstract
Objective Although obesity can result in high morbidity and mortality in surgical outcomes because of multiple comorbidities, determinants of outcome in obese patients who underwent endometrial cancer surgery remain unclear. The aim of this study is to assess the relationship between body mass index (BMI) and surgical outcomes in obese patients with endometrial cancer.
Methods An institutional retrospective review of the demographic details, clinical characteristics, and follow-up data of 142 patients with endometrial cancer who underwent surgery during a 72-month period was performed. The patients were divided into three groups based on their BMI; patients with BMI < 25 were identified as normal weight, patients with BMI between 25 and 30 were accepted as overweight, and those with BMI ≥ 30 kg/m2 were identified as obese. The groups' demographic and clinical variables were compared.
Results Of the 142 patients, 42 were in the normal weight group, 55 in the overweight group, and 45 in the obese group. Age, surgical procedures, blood loss, preoperative health status, and metastatic lymph nodes did not show a significant difference between groups. However, surgery time and total lymph nodes were higher in the obese group. (p = 0.02, p = 0.00, and p = 0.00, respectively). Common complications were anemia, fever, intestinal injury, deep vein thrombosis, fascial dehiscence and urinary infection. There was no significant difference according to the complications.
Conclusion Our results indicated that higher BMI was significantly associated with a longer duration of endometrial cancer surgery. Minimally invasive surgeries and conventional laparotomy could be performed safely in obese patients.
Neonatal Screening for Sickle Cell Disease in Western Andalusia: Results and Lessons Learnt after 3 Years of Implementation
Authors: Núñez-Jurado David , Payán-Pernía Salvador , Álvarez-Ríos Ana I. , Jiménez-Jambrina Margarita , Concepcion Pérez-De-Soto Inmaculada , José Palma-Vallellano Antonio , Zapata-Bautista Rocío , Carlos Hernández-Castellet José , Paz Garrastazul-Sánchez Mari , Arqueros-Martínez Víctor , Urbano-Ramos María del Mar , Abdelkader-Maanan Mohamed , Raúl García-Lozano José , Delgado-Pecellín Carmen 
Published: December 2022

Objective The aim of this study was to present the results obtained in the Newborn Screening Program (NSP) for sickle cell disease (SCD) in western Andalusia and the autonomous city of Ceuta in the first 3 years of implementation, and to describe the discrepancies found in the diagnosis of hemoglobinopathies between the screening method and the confirmatory tests.
Study Design A descriptive and retrospective study was carried out, and the findings obtained in the newborns included in the NSP between November 2018 and December 2021 were analyzed.
Results A total of 111,205 samples were screened by high-performance liquid chromatography (HPLC). The birth prevalence of SCD, sickle cell trait, hemoglobin C carriers, and the compound heterozygosity Hb C/β-thalassemia was 1/12,356, 1/467, 1/1,278, and 1/55,602 newborns, respectively. Although there was a correlation between the first-line HPLC screening technique (VARIANTnbs HPLC analyzer, Bio-Rad) and the confirmatory tests in most cases, major discrepancies were found in detecting carriers of G-Philadelphia, D, E, and O-Arab hemoglobin variants, with the former having an incidence of 1/10,110 and the others 1/22,241. The carrier status of Hb G-Philadelphia produced an FAD pattern on the screening method that could be mistaken as Hb D, while Hb O-Arab was identified as an FA5 pattern. Hb D was initially recognized as Hb D in two cases.
Conclusion An NSP requires at least two different combined methods in order to identify the hemoglobin variant with sufficient certainty. Furthermore, even though software solutions for HPLC suggest a pattern, it must be confirmed with another technique to obtain a correct interpretation of the chromatograms.
Key Points
Role of Vascular Receptors in the Development of Hypertension in the Elderly Population
Authors: Shaulian Shlomo Yosef , Makaryus Amgad N. , Zeltser Roman 
Published: December 2022

AbstractHypertension is a disease common in adults, with many risk factors and potentially life-threatening outcomes. Blood pressure is controlled by receptors that inform the brain about the amount of pressure inside the arteries, and the amount of oxygen and carbon dioxide in the blood, respectively. Research has revealed that baroreflex sensitivity (BRS) decreases with increasing age and that there is a high correlation between hypertension and low BRS. However, various studies with differing results have indicated that high blood pressure is what causes BRS to decline, and vice versa. Several studies have shown very conflicting results on the correlation between chemoreflex and age; there have been indications of chemoreflex having a positive, negative, and zero correlation with age. In several experiments, the surgical removal of the chemoreceptors of hypertensive rats was followed by a decrease in blood pressure. These animal experiments, and an additional noninvasive human experiment in which the chemoreceptors were temporarily “shut off,” are reasons why more attention should be given to chemoreceptors as a route of alleviating hypertension.
Optimization of Phenylalanine Cut-Off Value in Newborn Screening Based on Blood Sampling Time
Authors: Liu Zhijuan , Jin Huiya , Ye Minggang , Han Rui , Han Ningning , Zhao Jing 
Published: December 2022

Objective The aim of this study was to optimize the cut-off value of phenylalanine (Phe) for phenylketonuria (PKU) screening in Xinjiang Uygur Autonomous Region based on the time of blood sampling.
Study Design In this study, 110,806 neonates born in 91 obstetrics and gynecology hospitals of Xinjiang Uygur Autonomous Region between June 2017 and December 2019 were divided into two groups (i.e., groups 1 and 2) based on the sampling time. The concentration of Phe was determined using fluorimetric method. The optimization of the Phe cut-off value was conducted using the receiver operating characteristic curve from the treating set involving 80,354 neonates. Then, the diagnostic values of the optimized Phe cut-off value were evaluated using validation set involving 30,452 neonates, based on the comparison of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) obtained from conventional cut-off value.
Results A range of cut-off values was used for preliminary Phe concentrations in the two groups to analyze the sensitivity, specificity, PPV, and NPV. The optimized cut-off value of Phe in group 1 was 2.0, while that in the group 2 was 2.21. A comparison was given to PPV, NPV, sensitivity, and specificity generated by the optimized cut-off value and the conventional cut-off value, which yielded similar sensitivity, specificity, and PPV, and less recalled number of samples.
Conclusion The optimization of cut-off value of Phe based on sampling time is feasible for PKU screening in Xinjiang Uygur Autonomous Region. In addition, the false positive rate was significantly reduced, which may save more efforts in sample recalling process.
Key Points
Commercial Surrogacy: An Overview
Authors: Brandão Pedro , Garrido Nicolás 
Published: December 2022

AbstractObjective Surrogacy is the process in which a woman carries and delivers a baby to other person or couple, known as intended parents. When carriers are paid for surrogacy, this is known as commercial surrogacy. The objective of the present work is to review the legal, ethical, social, and cultural aspects of commercial surrogacy, as well as the current panorama worldwide.Methods This is a review of the literature published in the 21st century on commercial surrogacy.Results A total of 248 articles were included as the core of the present review. The demand for surrogate treatments by women without uterus or with important uterine disorders, single men and same-sex male couples is constantly increasing worldwide. This reproductive treatment has important ethical dilemmas. In addition, legislation defers widely worldwide and is in constant change. Therefore, patients look more and more for treatments abroad, which can lead to important legal problems between countries with different laws. Commercial surrogacy is practiced in several countries, in most of which there is no specific legislation. Some countries have taken restrictive measures against this technique because of reports of exploitation of carriers.Conclusion Commercial surrogacy is a common practice, despite important ethical and legal dilemmas. As a consequence of diverse national legislations, patients frequently resort to international commercial surrogacy programs. As of today, there is no standard international legal context, and this practice remains largely unregulated.
Forgotten Poles in the history of neurology: from Flatau to Frey
Authors: Gotowiec Mateusz 
Published: December 2022

AbstractWith the majority of eponyms being removed from disease classification systems, it is even more difficult to remember the neurologists who influenced the development of techniques and understanding of the brain over the last centuries. Determining whether Polish researchers were given similar attention to Western equivalents based on eponymic presence in medical databases is an interesting way to provide an overview of unremembered Polish neurologists. This work aims to recognize the developments of forgotten Polish neurologists, whose work, although important, was not properly appreciated over the centuries.
Pressure induced modification of the electronic properties of stilbene by two-photon spectroscopy
Authors: Agati M. , Fanetti S. , Bini R. 
Published: December 2022

Carbon nanothreads are the most exciting carbon based nanomaterials recently discovered. Obtained by compressing aromatics around 20 GPa, they are characterized by potentially exceptional mechanical properties. The reaction mechanisms have been partly elucidated through computational studies and x-ray diffraction experiments. However, in all these studies, the electronic modifications to which the molecule is subjected with increasing pressure are neglected as also if, and to which extent, the electronic excited states are involved in the high-pressure reactivity. In fact, the pressure increase induces remarkable changes in the electronic properties of molecular crystals, which are often directly related to the reaction’s onset and path. We report the pressure evolution of the two-photon induced emission spectrum of crystalline stilbene, the archetype of a class of molecules from which double-core nanothreads are obtained, with the twofold purpose of gaining insight into the reaction mechanism and monitoring if the structural changes observed in x-ray diffraction studies have a detectable counterpart in the electronic properties of the system. The freezing of the spectral diffusion observed on rising pressure is ascribed to a hampered conformational rearrangement because of the larger stiffness of the local environment. The transition to the high pressure phase where the nanothreads form is revealed by the slope change of the pressure shift of all spectral components, while the progressive intensification with pressure of the 0-0 transition suggests a strengthening of the ethylenic bond favoring the charge delocalization on the benzene moieties, which is likely the trigger of the chemical instability.
A study on prenucleation and heterogeneous nucleation in liquid Pb on solid Al using molecular dynamics simulations
Authors: Men H. , Fan Z. 
Published: December 2022

In this paper, we investigate prenucleation and heterogeneous nucleation in the liquid Pb/solid Al system as an example of systems with large lattice misfit using molecular dynamics simulation. Solid Pb and Al have a large positive lattice misfit (f) of 18.2% along the densely packed [110] direction. This study reveals that prenucleation occurs at 600 K (an undercooling of 15 K), and a 2-dimensional (2D) ordered structure forms at the interface with a coincidence site lattice (CSL) between the first Pb and first Al layers. The CSL accommodates the major part of the f, and only a small residual lattice misfit (fr) of 1.9% remains. The formation of the CSL transforms the original substrate into a considerably potent nucleant, where the first Pb layer becomes the new surface layer of the substrate. At an undercooling of about 22 K, nucleation proceeds by merging 2D ordered structure through structural templating: the second Pb layer is epitaxial to the CSL Pb layer, the third Pb layer largely accommodates the fr, and the fourth Pb layer is a nearly perfect crystalline plane. Further analysis indicates that the interface with the CSL has a lower interfacial energy than with a cube-to-cube orientation relationship. For the first time, we established that the CSL was an effective mechanism to accommodate the f for systems with a large positive misfits. Heterogeneous nucleation is governed not by a single mechanism (misfit dislocations in Turnbull’s model), but instead by various mechanisms depending on f. This study sheds new light on the atomistic mechanism of heterogeneous nucleation.
Optimal transmission estimation with dark counts
Authors: Goldberg Aaron Z , Heshami Khabat 
Published: December 2022

Abstract
Transmission measurements are essential from fibre optics to spectroscopy. Quantum theory dictates that the ultimate precision in estimating transmission or loss is achieved using probe states with definite photon number and photon-number-resolving detectors (PNRDs). Can the quantum advantage relative to classical probe light still be maintained when the detectors fire due to dark counts and other spurious events? We demonstrate that the answer to this question is affirmative and show in detail how the quantum advantage depends on dark counts and increases with Fock-state-probe strength. These results are especially pertinent as the present capabilities of PNRDs are being dramatically improved.
Conceptual design of DIII-D experiments to diagnose the lifetime of spin polarized fuel
Authors: Garcia A.V. , Heidbrink W.W. , Sandorfi A.M. 
Published: December 2022

Abstract
In magnetic fusion experiments, the cross sections for the D-T and D-3He fusion reactions are increased by as much as 50% if the fuel remains spin polarized parallel to the magnetic field. The goal of this study is to assess the feasibility of lifetime measurements of spin polarization, in magnetic fusion relevant conditions, on the DIII-D tokamak using relative changes in charged fusion product (CFP) loss measurements that depend upon the differential fusion cross section dσ/dΩ. Relative measurements that capture changes in the escaping CFP pitch, poloidal, and energy distributions are studied in two realistic TRANSP calculated plasma scenarios: (a) vector-polarized 3He and D pellets are injected into a hot hydrogen plasma to produce thermonuclear reactions, and (b) a tensor-polarized deuterium pellet is injected into an L-mode hydrogen background plasma that includes unpolarized 3He neutral beam injection. Ideal CFP signals in both scenarios show substantial pitch sensitivity to polarization for 14.7 MeV proton detection at a poloidal angle of

−

56

∘

(on the outer wall in the ion

∇
B

direction), and strong sensitivity to polarization for 3.6 MeV alpha flux detection by an array of poloidal detectors. Energy-resolved measurements of 14.7 MeV protons are also sensitive to the degree of polarization for the

−

56

∘

port in the beam-plasma scenario. A realistic assessment of CFP signals in the thermonuclear scenario show count rates in the range of

2
×

10
4

cps for pitch-resolved proton detection and

2
×

10
5

cps for alpha flux measurements. Reduced chi-squared

χ

r

2

calculations show polarization lifetime measurements are feasible for either proton or alpha detection of both enhanced or suppressed polarization for the thermonuclear scenario. Measurements of gamma rays produced in the weak

D

+

3

He

→
γ
+

5

Li

branch complement the CFP measurements.
Erratum: Exact quench dynamics of symmetry resolved entanglement in a free fermion chain (2021 J. Stat. Mech.
093102)
Authors: Parez Gilles , Bonsignori Riccarda , Calabrese Pasquale 
Published: December 2022

Abstract
The study of the entanglement dynamics plays a fundamental role in understanding the behaviour of many-body quantum systems out of equilibrium. In the presence of a globally conserved charge, further insights are provided by the knowledge of the resolution of entanglement in the various symmetry sectors. Here, we carry on the program we initiated in Parez et al (2021 Phys. Rev. B 103 L041104), for the study of the time evolution of the symmetry resolved entanglement in free fermion systems. We complete and extend our derivations also by defining and quantifying a symmetry resolved mutual information. The entanglement entropies display a time delay that depends on the charge sector that we characterise exactly. Both entanglement entropies and mutual information show effective equipartition in the scaling limit of large time and subsystem size. Furthermore, we argue that the behaviour of the charged entropies can be quantitatively understood in the framework of the quasiparticle picture for the spreading of entanglement, and hence we expect that a proper adaptation of our results should apply to a large class of integrable systems. We also find that the number entropy grows logarithmically with time before saturating to a value proportional to the logarithm of the subsystem size.
Probabilistic prediction of algal blooms from basic water quality parameters by Bayesian scale-mixture of skew-normal model
Authors: Liu Muyuan , Hu Jing , Huang Yuzhou , He Junyu , Effiong Kokoette , Tang Tao , Huang Shitao , Perianen Yuvna Devi , Wang Feier , Li Ming , Xiao Xi 
Published: December 2022

Abstract
The timeliness of monitoring is essential to algal bloom management. However, acquiring algal bio-indicators can be time-consuming and laborious, and bloom biomass data often contain a large proportion of extreme values limiting the predictive models. Therefore, to predict algal blooms from readily water quality parameters (i.e. dissolved oxygen, pH, etc), and to provide a novel solution to the modeling challenges raised by the extremely distributed biomass data, a Bayesian scale-mixture of skew-normal (SMSN) model was proposed. In this study, our SMSN model accurately predicted over-dispersed biomass variations with skewed distributions in both rivers and lakes (in-sample and out-of-sample prediction R2
ranged from 0.533 to 0.706 and 0.412 to 0.742, respectively). Moreover, we successfully achieve a probabilistic assessment of algal blooms with the Bayesian framework (accuracy >0.77 and macro-F
1 score >0.72), which robustly decreased the classic point-prediction-based inaccuracy by up to 34%. This work presented a promising Bayesian SMSN modeling technique, allowing for real-time prediction of algal biomass variations and in-situ probabilistic assessment of algal bloom.
The evolution of the Fram Strait sea ice volume export decomposed by age: estimating with parameter-optimized sea ice-ocean model outputs
Authors: Yang Yijun , Min Chao , Luo Hao , Kauker Frank , Ricker Robert , Yang Qinghua 
Published: December 2022

Abstract
Sea ice export through the Fram Strait is crucial in the dynamic evolution of Arctic sea ice and can further modulate Arctic sea ice mass balance as well as the ocean thermohaline circulation. In this study, based on outputs from a parameter-optimized and fully physical ocean–sea ice coupled model and sea ice age observation, we estimate sea ice volume (SIV) flux and its age evolution via the Fram Strait. The estimate of mean annual SIV flux is about 1605

±

315 km3 yr−1 without a significant trend for 1979–2021. Combining with sea ice age data, the variation of the sea ice age and its corresponding SIV flux are obtained for 1984–2020. The SIV flux of 1st-year ice significantly increases as expected, but it still contributes very little to the total flux in the 2010s with a proportion of 3.5%. SIV fluxes of different ages in multi-year ice present diverse variations. The proportions of 2nd-year ice and 3rd-year ice in the annual SIV flux show an extreme increase from 6.8% and 25.0% in the 1980s to 49.0% and 38.8% in the 2010s, respectively, while the proportions of 4th-year ice and 5th-year and older (5+ year) ice significantly decrease from 22.8% and 45.0% in the 1980s to 7.1% and 1.6% in the 2010s, respectively. Meanwhile, the prevailing age of annual volume export via Fram Strait shifts from 4th-year and 5+ year ice to 2nd-year and 3rd-year ice around 2007/2008. It is worth noticing that the variation in Fram Strait ice export modulates the variation in Arctic SIV prior to 2008, but the reverse is true after 2008, indicating a decreasing influence of Fram Strait SIV export on Artic SIV variability with decreasing sea ice age. The results are beneficial to promote the understanding of the evolution of Fram Strait SIV export under the warming Arctic.