bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morus alba L. leaves modulate sweet (TAS1R) and bitter (TAS2R) taste in the studies on human receptors – is it a new perspectives of white mulberry leaves utilization in food production?
Authors: Przeor Monika , Jokiel Maria 
Published: August 2023

Abstract
From the nutritional point, the main direction for white mulberry (Morus alba L.) elements utilization so far is to create dietary supplements or functional foods for diabetics or over-weight patients. Leaves are widely known as a valuable source of bioactive compounds responsible for its antioxidant and antidiabetic effects, both in animals and humans. We found that processed leaves can be also considered as a bitter and/or sweet taste modulators – important aspect in designing of new functional foods. The aim of the study was to validate the inhibitory effect of Morus alba L. on the TAS2R3 and TAS2R13 bitter taste and TSA1R2/TSA1R3 receptors, and determine the changes that conditioning process caused in such receptors. Effect on the receptors was evaluated in specially transfected HEK293T cells, and the inhibition ratio was measured using the calcium release test. Moreover, the stability of phenolic acids and flavonols in the simulated intestinal in vitro digestion process was determined. Results showed that the tested Morus alba leaf extracts were rich in gallic, chlorogenic and caffeic acids together with rutin and quercetin 3-(6-malonyl)-glucoside, while the conditioning process positively affected on their amount. Mostly identified phenolics were reduced as a result of in vitro digestion. In taste receptors test, it was found that the phytochemicals from conditioned Morus alba leaf extract enhanced sweet taste, together with reduction of bitter taste receptors activity in some cases. To conclude, we found Morus alba, especially conditioned for 4 hours, seems to be valuable modulator of taste, what should be considered in future as a crucial reason for its new utilization.
Suppressing effect of flavonoid compounds on lipids photooxidation of sheep red blood cells and oleic acid photooxidation
Authors: Hajimohammadi Mahdi , Mahboobi Fatemeh Sheikh , Wu Haizhou 
Published: August 2023

Abstract

Photosensitizers and pigments in raw meat such as porphyrins, riboflavin, and myoglobin after incorporation with light beam prompt the generation of singlet oxygen (1O2) from triplet oxygen (3O2) and causes oxidative rancidity of meat products. In this study, the results of photooxidation reactions of sheep erythrocyte (red blood cell) model as a model rich in hemoglobin and phospholipids bilayer, and oleic acid model were obtained by 1H NMR spectroscopy, TBARS assay and iodometric titration. In both models, the rate of lipid photooxidation in the presence of hydroalcoholic extracts of Turmeric (Curcuma longa L.) and Cumin (Cuminum cyminum L.) as natural antioxidants, Butyl hydroxytoluene (BHT) as a synthetic antioxidant and sodium azide (NaN3) as a well-known 1O2 scavenger were decreased in the order of NaN3 > Turmeric > Cumin > BHT. It was proved during the photooxidation process, there is a direct association between the amount of flavonoid compounds and 1O2 scavenging.
Meta-QTL analysis for mining of candidate genes and constitutive gene network development for viral disease resistance in maize (Zea mays L.)
Authors: Gupta Mamta , Choudhary Mukesh , Singh Alla , Sheoran Seema , Kumar Harish , Singla Deepak , Rakshit Sujay 
Published: August 2023

Abstract
Viral diseases substantially impact global maize production. Genetic resistance is the most feasible approach to combat losses caused by viral diseases. Various researchers have mapped several QTLs for viral disease resistance (VDR) in maize. The meta-QTL (MQTL) analysis is the best way to leverage such independent studies to find overlapping or common genomic regions governing target traits. Towards this direction, in the present study, the MQTL analysis was carried out using a total of 39 QTL mapping investigations on resistance against 14 viral diseases. 53 (27.04%) out of 196 QTLs could be projected on the maize genome. The study discovered 14 MQTLs for resistance against 11 viral diseases on chromosomes 1, 3 and 10. Marker trait associations (MTAs) in genome-wide association studies confirmed the role of two MQTLs (MQTL3_2 and MQTL10_2) for VDR. The identified MQTL regions harboured 1715 candidate genes. Further, the genes expressed constitutively in the MQTLs identified for VDR were analyzed for their involvement in metabolic pathways. The identified genes were found to be implicated in antiviral resistance, and thus, constitute a good resource for allele mining to decipher the mechanism of plant-virus interactions.
Feature Classification of Multi-source Remote Sensing Data Based on Improved U-Net Network
Authors: Zhang Guanjin , Roslan Siti Nur Aliaa , Wang Ci , Quan Ling 
Published: August 2023

Abstract
In recent years, remote sensing images of various types have found widespread applications in resource exploration, environmental protection, and feature classification. However, relying solely on a single optical or synthetic aperture radar (SAR) image as the data source for feature classification studies may not suffice to achieve the desired accuracy in ground information monitoring. One widely employed neural network for remote sensing image feature classification is the U-Net network, which is a classical semantic segmentation network. Nonetheless, the U-Net network has limitations such as poor classification accuracy, misclassification and omission of small-area features, and a large number of network parameters. To address these challenges, this research paper proposes an improved approach that combines both optical and SAR images in bands for feature classification and enhances the U-Net network. The approach incorporates several modifications to the network architecture. Firstly, the encoder-decoder framework serves as the backbone feature-extraction network. Additionally, a convolutional block attention mechanism is introduced in the feature extraction stage. Instead of pooling layers, convolutions with a step size of 2 are utilized, and the Leaky ReLU function is employed as the network's activation function. This design offers several advantages: it enhances the network's ability to capture feature characteristics from both spatial and channel dimensions, resolves the loss of feature map information while reducing network parameters, and ensures non-zero gradients during the training process. The effectiveness of the proposed method is evaluated through feature classification experiments conducted on optical, SAR, and combined optical and SAR datasets. The results demonstrate that our method achieves classification accuracies of 89.05%, 86.09%, and 90.89% on the three datasets, respectively, with corresponding mIoU values of 0.8104, 0.7804, and 0.8667. Compared to the traditional U-Net network, our method exhibits improvements in both classification accuracy and mIoU to a certain extent.
Characterization of Twelve Erwinia amylovora Bacteriophages
Authors: Besarab Natalya V. , Letarov Andrey V. , Belalov Ilya S. , Golomidova Alla K. , Kulikov Eugene E. , Letarova Maria A. , Boldyreva Daria I. , Lagonenko Alexander L. , Evtushenkov Anatoly N. 
Published: August 2023

Abstract
E. amylovora bacteriophages are of interest as fire blight control agents. This paper presents data on the biology and molecular genetic properties of 12 E. amylovora bacteriophages. Seven of them have complete genome sequences in GenBank and belong to the representatives of Caudoviricetes; Vequintavirinae, Ounavirinae and Autographiviridae.
Dynamic Analysis and Optimal Control of Rumor Victims Affected by Positive Information on the Internet
Authors: Li Jundi , Hu Yuhan , Meng Wang 
Published: August 2023

Abstract
The spread of rumors can have a profound impact on people’s physical and mental health, as well as social stability and development. From the perspective of rumor victims, this article proposes a Susceptible-Infected-Victims-Removed (SQVR) model which combines positive information dissemination on the internet. The model considers the impact of positive information on both rumor victims and spreaders on the internet, and proves the existence and stability of the model’s equilibrium point. Based on the selection of optimized control variables, a control strategy was designed to effectively suppress the spread of rumors and reduce the number of victims. Numerical simulations confirmed the theoretical analysis results and the influence of the system on the changes in control parameters. Furthermore, the SQV R model was compared with the SIR model, and the research indicated that the SQV R model reached equilibrium faster than the SIR model. Expanding the scope of positive information dissemination can effectively suppress the spread of rumors, rapidly free the victims of rumors from their predicament, and reduce the harm caused by rumors.
A Fourier Integral Formula for Logarithmic Energy
Authors: Frerick Leonhard , Müller Jürgen , Thomaser Tobias 
Published: August 2023

Abstract
A formula which expresses logarithmic energy of Borel measures on Rn in terms of the Fourier transforms of the measures is established and some applications are given. In addition, using similar techniques a (known) formula for Riesz energy is reinvented.
Restoration of urban rivers with water quality modeling approach (Case Study: Kan River, Tehran City, Iran)
Authors: Yekta Nazli Moghadam , Rafati Maryam , Karimi Abdolreza , Sajjadi Nooshin 
Published: August 2023

Abstract

This research focused on the urban section of Kan river in Tehran and aimed to rehabilitate it through treated wastewater by using the HEC-RAS quality model. The study area was longitudinally divided into eight sections and the sampling stations were selected based on the research objectives, and the sampling procedure was performed during the water year 2021 (from October 2020 to September 2021. The results showed that the water quality in terms of BOD and DO was lower in Section G than in other sections. This indicates the critical status of the water quality due to the entry of sewage and surface runoff from Persian Gulf Residential Town and Behshahr industries. The results also indicated that the nitrate changes were high in sections, B, C, D, E and F because of agricultural activities, surface runoff, and human wastewater. The highest phosphate level was measured in Section E and then Section F, which can be attributed to the entry of detergents from the located buildings. The model result after the allocation of the effluent of Tehran's sixth water treatment plant demonstrated the increased water quality in all studied sections of Kan River. The vulnerability assessment of this river showed that sections B and C, with a score of 26.7 and 67.6, were exhibited the highest and the lowest restoration potential, respectively. Based on the zoning of Kan River for restoration measures, Section B fell into the nature utilization zone (NUZ) and Facility Use Zone (FUZ). In addition, sections C, D, and G fell into Artificially Development Zone (ADZ) and Facility Use Zone (FUZ), and Development and Nature Mix Zone (DNMZ) and Facility Use Zone (FUZ), respectively. Since all the sections exhibited development potential, ADZ was considered in all zones, except B. Finally, some management solutions such as Flood control, the construction of low-water channels and falls and, wastewater allocation as the main suggestion were proposed to improve the water quality, and restore Kan River.
Effectiveness of creative story therapy for dementia: A Systematic Review and Meta-Analysis
Authors: Ma JinLong , Wang Qian , Lv Shi , Xu Yuzhen , Wei Baojian 
Published: August 2023

Abstract
Objective To conduct a meta-analysis of the effectiveness of creative story therapy versus routine nursing alone for the treatment of dementia.Methods We manually searched PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), China VIP Database (VIP), China Biomedical Literature Database (CBM), and Wanfang Data up to May 2023. Randomized controlled trials (RCTs) of creative story therapy combined with routine nursing versus routine nursing for the treatment of dementia were included.Results A total of 597 participants were enrolled in the 9 RCTs. Among them, 296 were in the creative story therapy group, and 301 were in the routine nursing group. We found statistically significant effects of creative story therapy combined with routine nursing on cognitive function [standardized mean difference (SMD) = 0.99, 95% CI 0.57, 1.41, P < 0.00001], CSDD score [mean difference (MD) = − 1.71, 95% CI − 3.27, − 0.14, P < 0.00001], quality of life [SMD = 0.97, 95% CI 0.04, 1.90, P = 0.04], and social communication [MD = 0.46, 95% CI 0.17, 0.74, P < 0.00001] between the creative story therapy group and routine nursing groups; no significant difference in change in basic needs communication [MD = 0.09, 95% CI − 0.58, 0.76, P < 0.00001].Conclusion This meta-analysis shows that creative story therapy combined with routine nursing has significant effectiveness in improving cognitive function, depression, quality of life, and social communication in people with dementia. More high-quality RCTs are required to validate these results.
Threshold Effect of ICT in the Impact of the Informal Economy on CO2 Emissions
Authors: Shahnazi Rouhollah , Jamshidi Neda , Shafiei Majid 
Published: August 2023

Abstract
The direct and indirect impacts of information and communication technology (ICT) on environmental pollution and carbon dioxide (CO2) emissions in developing economies are significant. This study investigates the indirect effects of ICT on CO2 emissions through the informal sector. A threshold panel model is employed to estimate the impact of ICT on the informal sector's effect on CO2 emissions in 24 high-income countries and 30 upper-middle and lower-middle income countries from 1995–2019. The findings indicate that in high-income countries, both ICT and the informal sector contribute to reducing CO2 emissions. When ICT surpasses the threshold of 64,469, the informal sector's reducing effect on CO2 emissions increases. In countries with upper-middle and lower-upper-middle incomes, ICT reduces CO2 emissions, but the informal sector increases them. ICT has two thresholds, 0.976 and 61.57, in these countries. As ICT surpasses each threshold, the incremental effect of the informal sector on CO2 emissions declines. Furthermore, the Kuznets curve is confirmed in both country groups. Energy consumption and population density have a significant positive impact on CO2 emissions.
The effect of structured exercise on non-exercise physical activity and sedentary behaviour in persons with mild Multiple Sclerosis and healthy controls
Authors: Nieste Ine , Spaas Jan , Franssen Wouter M.A. , Asch Paul Van , Savelberg Hans H.C.M. , Eijnde Bert O. 
Published: August 2023

Abstract
Background Exercise interventions fail to increase objective physical activity (PA) in persons with Multiple Sclerosis (PwMS), while they self-report higher exercise participation. This suggests that PwMS change their non-exercise PA (NEPA). We aimed to explore NEPA changes of PwMS and healthy controls (HC), and whether these constrain exercise adaptations.
Methods Twenty-nine mildly-disabled PwMS and 26 HC completed a 10-month home-based running program. The primary outcome was time in different NEPA intensities (light intensity PA [LIPA] and moderate-to-vigorous intensity PA [MVPA]) and in sedentary behaviour ([SB]; total and uninterrupted SB) at baseline (T1), after 5 (T2) and 10 (T3) months of exercise. Data were averaged over days with and without exercise sessions (EX and NONEX days). Secondary outcomes included patient-reported and physical exercise adaptations (fatigue, walking mobility, blood pressure, body composition and cardiorespiratory fitness).
Results A significant reduction in non-exercise MVPA was observed from T1 to T2 (-113±31 min/week, p=0.006) and from T1 to T3 (-95±26 min/week, p=0.007) in PwMS, which approximately matched the weekly exercise duration at those time points. PwMS also increased their uninterrupted SB on NONEX days compared to EX days (+0.7±0.3h, p=0.003). There were no changes in MVPA or SB of HC (group×time effect MVPA: p=0.017; group×EX day effect uninterrupted SB: p=0.003). Secondary outcomes improved similarly in both groups and were not associated with NEPA/SB changes.
Conclusions In contrast to HC, PwMS significantly changed their NEPA and the pattern in which they accumulated SB in response to structured exercise. This might be a necessary behavioural compensation in order to adhere to the exercise intervention and did not constrain patient-reported and physical outcomes. Future research is warranted to unravel the underlying causes and to investigate the effects on other exercise adaptations, such as cardiometabolic health.
Trial registration The present study was registered (December 10, 2019) at clinicaltrials.gov as NCT04191772.
The comparison of bone marrow and adipose tissue-derived mesenchymal stem cells effect within alginate hydrogel scaffold in burned mice infected by methicillin-resistant Staphylococcus aureus
Authors: Absari Javad , Ohadi Elnaz , Jahangir Mohammadsaleh , Razavi Shabnam , Darban-Sarokhalil Davood , Karimi Roya 
Published: August 2023

Abstract
Background
Burns are a major cause of death, with infections accounting for 75% of burn-related fatalities. Methicillin-resistant Staphylococcus aureus (MRSA) can infect burn wounds, and conventional antibiotics are not very effective. Mesenchymal stem cells (MSCs) have shown promise in wound healing and protection against infection with alginate scaffold showing synergistic effect and restorative properties.Therefore, we conducted a study comparing the effects of adipose-derived MSCs and bone marrow-derived MSCs, both integrated into alginate scaffolds, in a murine model infected with Staphylococcus aureus.
Methods
MSCs were isolated and encapsulated in alginate scaffolds. Animal study included seven groups (untreated, treated with antibiotic mupirocin, adipose and bone marrow MSCs, alginate scaffold, adipose and bone marrow MSCs encapsulated in alginate scaffolds). Animals examined for seven days. Histological analyses and bacterial counting were conducted to determine the effectiveness of these methods.
Results
The treatment reduced the bacterial count and histological analysis of autopsies from the combination therapy group (MSCs with alginate scaffolds) showed significant effect on the wound healing compared to other groups.
Conclusion
MSCs encapsulated in alginate scaffolds have antimicrobial activity in a model of MRSA-infected burned mice, and accelerates the overall process of burn wound healing.
Examination of risk factors for high Edinburgh Postnatal Depression Scale scores: a retrospective study at a single university hospital in Japan
Authors: SHIGA Tomomi , FURUI Tatsuro , MORISHIGE Ken-ichirou 
Published: August 2023

Abstract
Background: Perinatal mental health, such as postpartum depression, is an important issue that can threaten the lives of women and children. It is essential to understand the risk factors in advance and intervene before they can lead to postnatal depression. The risk factors of postpartum depression are reported to vary considerably in Japan. This study aimed to evaluate the risk factors for women with high Edinburgh Postnatal Depression Scale (EPDS) scores and to find women who may need our intervention to prevent postpartum depression.
Methods: This was a retrospective observational study conducted at a single center. At the one-month check-up after birth, the EPDS test was performed in 1625 women who gave birth at our hospital from 2008 to 2016. We evaluated maternal, birth, neonatal and social factors and the breastfeeding status from medical records. Thereafter, we examined the factors that contributed to a high EPDS score.
Results: There were 284 women in the high-score group with an EPDS of ≥ 9, and 1341 women in the low-score group with an EPDS score ≤ of 8. Maternal mental disorders and neonatal transport were significantly associated with high EPDS scores. Conversely, exclusive breastfeeding was significantly associated with the low-score EPDS group.
Conclusions: The principal factor for high EPDS scores was a mental disease. Based on this result, we suggest that early intervention in women at high risk for postpartum depression could prevent serious consequences such as abuse and suicide.
Mucoadhesive and thermosensitive Bletilla striata polysaccharides/chitosan hydrogel loaded nanoparticles for rectal drug delivery in ulcerative colitis
Authors: Zhao Shiyi , Zhang Junbo , Qiu Mengyu , Hou Yusen , Li Xuebo , Zhong Guofeng , Gou Kaijun , Li Jingjing , Zhang Chen , Qu Yan , Wang Xiao 
Published: August 2023

Abstract
Ulcerative colitis (UC) is a chronic disease with diffuse mucosal inflammation limited to the colon. A topical drug delivery system that could be facilely performed and efficiently retained at colon are attractive for clinical ulcerative colitistreatment. Herein, a novel platform for rectal administration of thermosensitive hydrogel co-loaded with nanoparticles to treat ulcerative colitis was developed. Thiolated-hyaluronic acid was synthesized, and prepared nanoparticles with zein and Puerarin. And the Bletilla striatapolysaccharides with colonic mucosa repair effect was oxidized, and mixed with chitosan and β-sodium glycerophosphate to prepare thermosensitive hydrogel. Thermosensitive hydrogels were combined with nanoparticles to investigate their mucosal adhesion, retention, and permeability, as well as their therapeutic effects on ulcerative colitis. Thiolated-hyaluronic acid nanoparticles had good stability, and could be quickly converted into hydrogel at body temperature when combined with thermosensitive hydrogel. The nanoparticles-loaded thermosensitive hydrogel also was excellent at mucosal penetration, enhancing the retention time of drugs in colon, and effectively controlling drug release. In vivo ulcerative colitis treatment revealed that the nanoparticles-loaded hydrogel significantly repaired the colonic mucosa and inhibit colonic inflammation. Therefore, the thermosensitive hydrogel co-loaded nanoparticles will have a promising application in effective treatment of ulcerative colitis by topical administration.
Effect of pressure and temperature on survivability and proliferation of microorganisms in bentonite
Authors: Bartak Deepa , Bedrníková Eva , Kašpar Vlastislav , Říha Jakub , Hlaváčková Veronika , Večerník Petr , Šachlová Šárka , Černá Kateřina 
Published: August 2023

Abstract
As bentonite hosts a diverse spectrum of indigenous microorganisms with the potential to influence the long-term stability of deep geological repositories, it is essential to understand the factors determining microbial activity under repository conditions. Here, we focus on two such factors, temperature and swelling pressure, using a suspension of Cerny Vrch bentonite to boost microbial activity and visualise microbial response. Suspensions were exposed to differing pressures (10–15 MPa; simulating the effect of swelling pressure) and temperatures (60–90°C), followed by a period of anaerobic incubation at atmospheric pressure/laboratory temperature to assess microbial recovery. Microbial load and community structure were estimated using molecular-genetic methods, with presence of living cells confirmed through microscopic analysis. Pressure application had no influence on overall microbial activity or proliferation, proving that pressure evolution during bentonite swelling is not the key factor responsible for microbial suppression in saturated compacted bentonites. However, pressure treatment did cause significant shifts in microbial community structure. We also demonstrated that microbial activity decreased with increasing temperature, and that heat treatment strongly influenced bentonite microbial community structure, with several thermophilic taxa identified. A temperature of 90°C proved to be limiting for microbial activity and proliferation in all bentonite suspensions.