bluuebunny/crossref_metadata_2025_split huggingface dataset:
LASER ABLATION SYSTEM WITH A DIODE LASER FOR AMS 14C MEASUREMENT OF ORGANIC MATERIALS
Authors: Minamitani Fumina , Omori Takayuki , Yamazaki Kohei , Ozaki Hiromasa , Hakozaki Masataka , Yoneda Minoru 
Published: August 2023

ABSTRACTWe constructed a laser ablation (LA) system using a diode laser for the accelerator mass spectrometry radiocarbon (AMS 14C) measurement of organic materials. The system could extract adequate CO2 to analyze small masses (0.1 mg C) at a resolution of 250 µm by a 5.5 W diode laser. The LA system was assessed using standard materials (IAEA-C1, IAEA-C2, IAEA-C3, IAEA-C6, and Ox II) and applied to natural tree ring samples. For the LA sampling of organic samples, which generally results in incomplete combustion, tungsten (VI) oxide was used as an oxidant to achieve complete burning. The results of the measurement of standard materials showed a low 14C background of F14C 0.0085 ± 0.0005 and reasonable reproduction of 14C values. Finally, we applied this system to a single-year analysis of tree-ringed spruce timber in Alaska. It was observed to have a detectable background for the 14C bomb peak.
Local structural and functional MRI markers of compulsive behaviors and obsessive–compulsive disorder diagnosis within striatum-based circuits
Authors: Xu Chuanyong , Hou Gangqiang , He Tingxin , Ruan Zhongqiang , Guo Xinrong , Chen Jierong , Wei Zhen , Seger Carol A. , Chen Qi , Peng Ziwen 
Published: August 2023

AbstractBackgroundObsessive–compulsive disorder (OCD) is a classic disorder on the compulsivity spectrum, with diverse comorbidities. In the current study, we sought to understand OCD from a dimensional perspective by identifying multimodal neuroimaging patterns correlated with multiple phenotypic characteristics within the striatum-based circuits known to be affected by OCD.MethodsNeuroimaging measurements of local functional and structural features and clinical information were collected from 110 subjects, including 51 patients with OCD and 59 healthy control subjects. Linked independent component analysis (LICA) and correlation analysis were applied to identify associations between local neuroimaging patterns across modalities (including gray matter volume, white matter integrity, and spontaneous functional activity) and clinical factors.ResultsLICA identified eight multimodal neuroimaging patterns related to phenotypic variations, including three related to symptoms and diagnosis. One imaging pattern (IC9) that included both the amplitude of low-frequency fluctuation measure of spontaneous functional activity and white matter integrity measures correlated negatively with OCD diagnosis and diagnostic scales. Two imaging patterns (IC10 and IC27) correlated with compulsion symptoms: IC10 included primarily anatomical measures and IC27 included primarily functional measures. In addition, we identified imaging patterns associated with age, gender, and emotional expression across subjects.ConclusionsWe established that data fusion techniques can identify local multimodal neuroimaging patterns associated with OCD phenotypes. The results inform our understanding of the neurobiological underpinnings of compulsive behaviors and OCD diagnosis.
Artificial Intelligence and the Problem of Judgment
Authors: Pamuk Zeynep 
Published: August 2023

AbstractWill existing forms of artificial intelligence (AI) lead to genuine intelligence? How is AI changing our society and politics? This essay examines the answers to these questions in Brian Cantwell Smith's The Promise of Artificial Intelligence and Mark Coeckelbergh's The Political Philosophy of AI with a focus on their central concern with judgment—whether AI can possess judgment and how developments in AI are affecting human judgment. First, I argue that the existentialist conception of judgment that Smith defends is highly idealized. While it may be an appropriate standard for intelligence, its implications for when and how AI should be deployed are not as clear as Smith suggests. Second, I point out that the concern with the displacement of judgment in favor of “reckoning” (or calculation) predates the rise of AI. The meaning and implications of this trend will become clearer if we move beyond ontology and metaphysics and into political philosophy, situating technological changes in their social context. Finally, I suggest that Coeckelbergh's distinctly political conception of judgment might offer a solution to the important boundary-drawing problem between tasks requiring judgment and those requiring reckoning, thus filling a gap in Smith's argument and clarifying its political stakes.
Reply to Critics
Authors: Fabre Cécile 
Published: August 2023

AbstractA normative defense of espionage and counterintelligence activities in the service of foreign policy goals must show at least two things. First, it must show which foreign policy goals, if any, provide a justification for such activities. Second, it must provide an account of the means that intelligence agencies are morally permitted, indeed morally obliged, to use during those activities. I first discuss Ross Bellaby's probing critique of my defense of economic espionage. I then turn to the other four essays, which consider the ethics of the means by which espionage and counterintelligence activities are conducted.
Tinker, Tailor, Soldier, Informer: Revisiting the Ethics of Espionage in the Context of Insurgencies and New Wars
Authors: Dudai Ron 
Published: August 2023

AbstractThis essay starts by accepting Cécile Fabre's argument in her book Spying through a Glass Darkly that intelligence work, including using incentives and pressures to encourage betrayal and treason, can be morally justified based on the criteria of necessity, effectiveness, and proportionality. However, while assessments of spying tend to be based on Cold War notions, I explore it here in the messier reality of counterinsurgency, counterterrorism, and “new wars.” In addition, I suggest a methodological expansion: adding a sociological perspective to the ethical discussion by exploring the wider effects on society, over longer periods, of the operation of informers. Based on these shifts in perspective and context, I identify additional social harms generated by espionage that should lead to a more restrictive view of ethical espionage than the one emerging from Fabre's work. I argue that many of these social harms are created by the mass recruitment of informers, in asymmetrical conflicts where governments have leverage over suspected communities, and given the (often mistaken) belief that everyone recruited to act as informer is an “asset,” primarily providing advantages. I argue, therefore, that the decisive issue is one of scale: many of the ethical problems created by espionage in these contexts result from the widespread systematic recruitment of informers, while small-scale, targeted, ad-hoc recruitment can more easily avoid such problems.
The ‘Whole’ Truth about Biological Individuality in Kant’s Account of Living Nature
Authors: Wilks Anna Frammartino 
Published: August 2023

AbstractGiven the central place organisms occupy in Kant’s account of living nature, it might seem unlikely that his claims about biological wholes could be relevant to current debates over the problem of biological individuality. These debates acknowledge the multiple realizability of biological individuality in vastly different forms, including parts of organisms and complex groups of organisms at various levels of the biological hierarchy, sparking much controversy in attempts to characterize a biological individual. I argue that, far from being irrelevant to this controversy, Kant’s account provides a key insight for addressing the multiple realizability problem. I show how the reciprocal causality between a self-organizing whole and its parts, which Kant thinks characterizes a natural end, is not limited to organisms but is exhibited by numerous types of beings in living nature. Self-organizing wholes of various kinds, and at various biological levels, may count as biological individuals, depending on the degree to which their functionally integrated parts are represented by reflective judgement as a natural end.
Challenging Historiographic Assumptions: Opening Up Serialism with Pierre Boulez's Don
Authors: SALEM JOSEPH 
Published: August 2023

AbstractThis article combines historiographic reflections on the open-work concept in serial music with a new philology of Pierre Boulez's Don, the opening piece of Pli selon pli. I begin by presenting challenges in defining the open-work concept. I also deconstruct the dual use of the term ‘serialism’ to define a set of compositional techniques and a musical style. This leads me to a reconsideration of the similarities between the changing compositional strategies of Boulez and John Cage (and their influence on others) during a time of formal and stylistic experimentation in the 1950s. Finally, I segue to Boulez's compositional plans for Don. In doing so, I provide a concrete example of how the techniques of serialism often belie the aesthetic and extramusical connotations at play in works that are serial in style.
Effect of growth habit on grain yield and its component traits in horse gram [Macrotyloma uniflorum (Lam.) Verdc.]
Authors: Chandana Basalapura Rangegowda , Ramesh Sampangi , Kirankumar Rotti , Basanagouda Gonal , Ranjitha Gowdru Veerabhadrappa , Santhoshkumari Banakara 
Published: August 2023

AbstractIn common with other grain legumes, the growth habit in horse gram is one of the domestication-driven adaptive traits. Horse gram exhibits determinate and indeterminate types of growth habits. Determinate genotypes have non-overlapping vegetative and reproductive phases combined with a compact growth habit which enables farmers to produce horse gram in intercropping and multiple cropping systems, a common practice for sustainable agriculture production. Also, synchronous flowering, and pod development and maturity of determinate genotypes enable mechanical harvesting. Empirical studies have indicated a greater grain yield potential of indeterminate compared to determinate genotypes. However, we hypothesize that indeterminate and determinate genotypes do not differ for their grain yield potential if they are in isogenic genetic backgrounds. To test this hypothesis, we compared eight pairs of near isogenic (NI) indeterminate and determinate genotypes for their grain yield potential during two rainy seasons in one location and one rainy season in another location. The eight pairs of NI determinate and indeterminate genotypes differed significantly in each of the three test environments. Indeterminate genotypes produced a greater pod (harvestable) and grain (marketable) yields than their determinate counterparts only in a few genetic backgrounds. These results thus support our hypothesis that determinate genotypes are comparable to indeterminate ones, if not better than the latter.
A Robust Channel Head Extraction Method Based on High‐Resolution Topographic Convergence, Suitable for Both Slowly and Fastly Eroding Landscapes
Authors: Lurin Aude , Marc Odin , Meunier Patrick , Carretier Sébastien 
Published: August 2023

AbstractChannel networks exert a key control on drainage basins shape and dynamics, including the transfer of water and sediments throughout basins, and thus hydrosedimentary hazards. Landscape dissection by channels results from the competition between hillslope processes and channelized erosion processes such as overland flow or debris flows. In contrast to fluvial channelization, the transition from hillslopes to colluvial channels remains understudied, and high‐resolution LiDAR DEMs open new perspectives for the extensive extraction of channel heads. Several channel extraction methods exist but none is yet robust on fast eroding landscapes. Here we develop the CO2CHAIN method which identifies the hillslope to channel transition in drainage basins based on relative changes of local and upstream measures of flow convergence. We calibrate CO2CHAIN by fitting its results to channel head mapping made by geomorphologists in four contrasted basins in the United States and France with moderate to high erosion rates. Compared to two state‐of‐the‐art channel extraction methods, it fits best the experts' mapping in terms of average characteristics and variability without needing to be recalibrated and does not have to implement a drainage area threshold although it imposes a length scale threshold. This allows to revisit studies on channelization that have not yet included high erosion rate basins.
Triple‐Dip La Niñas in 1998–2001 and 2020–2023: Impact of Mean State Changes
Authors: Li Xiaofan , Hu Zeng‐Zhen , McPhaden Michael J. , Zhu Congwen , Liu Yunyun 
Published: August 2023

AbstractThis study compares the evolution of atmospheric and oceanic anomalies as well as predictions for the two most recent triple‐dip La Niña events in 1998–2001 and 2020–2023. Subsurface cooling in the equatorial Pacific was stronger and more persistent during 1998–2001. In contrast, surface easterly winds were stronger during 2020–2023 as was the east‐west sea surface temperature (SST) contrast along the equator. We argue that in the absence of appreciable equatorial Pacific heat discharge, persistent and strong surface trade winds and a strengthened mean zonal SST contrast across the tropical Pacific contributed to the development of the 2020–2023 triple‐dip La Niña. In terms of the subsurface layer heat budget, the growth and maintenance of unusually cold SSTs during the triple‐dip La Niña in 1998–2001 were mainly the result of ocean vertical entrainment and diffusion, as well as meridional advection, associated with enhanced equatorial upwelling; while for the triple‐dip La Niña in 2020–2023, zonal advection was the largest contributor. The two events were mostly well predicted by multi‐model averages at 1–8 months lead times. We hypothesize that mean state change with enhanced zonal SST contrast and trade winds over the last several decades altered the physical processes associated with the growth and maintenance of the most recent La Niña, affecting its predictability. Successful prediction in real‐time of the 2020–2023 event more than half a year in advance was surprising because there was little memory in oceanic heat content which is often considered a key predictor.
New Insights Into Composition Variation of Mars South Polar Layered Deposits From SHARAD Radar Sounder
Authors: Fang Peng , Zhang Jinhai 
Published: August 2023

AbstractThe south polar layered deposits (SPLD) of Mars record its Amazonian climate history. Detailed stratigraphic analyses of the SPLD will improve our understanding of the Martian depositional system. Radar reflection patterns correlate with the varying composition of the internal layers, thus providing a key to unlocking the depositional history of the SPLD and Martian paleoclimate. Using data from SHAllow RADar (SHARAD) onboard the Mars Reconnaissance Orbiter, we studied a new type of weak reflection pattern (shadow zone) across the SPLD. These shadow zones lack identifiable bases and are generally deeper than previously reported low‐reflection zones interpreted as sealed CO2 ice. The discrepancy between the waveforms of shadow zones in focused and unfocused radargrams was used to identify whether the shadow zones were associated with fog‐related data‐processing artifacts. Numerical simulations utilizing various dielectric models demonstrate that lossy materials are most likely the cause of the shadow zone. These materials are expected to exhibit a gradual increase in concentration with depth, ranging from pure water ice to lossy materials at a scale of >50 m. The presence of such lossy materials is consistent with the compositional heterogeneity of SPLD, but their origins remain obscure.
Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
Authors: Zhang Xiong , Hou Liangcai , Guo Zhou , Wang Genchun , Xu Jingting , Zheng Zehang , Sun Kai , Guo Fengjing 
Published: August 2023

AbstractOsteoarthritis (OA) is a multifactorial and increasingly prevalent degenerative disease that affects the whole joint. The pathogenesis of OA is poorly understood and there is a lack of therapeutic interventions to reverse the pathological process of this disease. Accumulating studies have shown that the overproduction of reactive oxygen species (ROS) and ROS-induced lipid peroxidation are involved in the pathogenesis of OA. 4-Hydroxy-2-nonenal (4-HNE) and malondialdehyde (MDA) have received considerable attention for their role in cartilage degeneration and subchondral bone remodeling during OA development. Ferroptosis is a form of cell death characterized by a lack of control of membrane lipid peroxidation and recent studies have suggested that chondrocyte ferroptosis contributes to OA progression. In this review, we aim to discuss lipid peroxidation-derived 4-HNE and MDA in the progression of OA. In addition, the therapeutic potential for OA by controlling the accumulation of lipid peroxidation and inhibiting chondrocyte ferroptosis are discussed.
N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis
Authors: Wang Ben , Zhang Jin , Li Guo , Xu Chenzhong , Yang Langmei , Zhang Jie , Wu Yalan , Liu Ye , Liu Zuojun , Wang Ming , Li Ji , Tang Xiaolong , Liu Baohua 
Published: August 2023

AbstractCutaneous wound healing, an integral part for protection of skin barrier, is a complex biological process and intimately associated with keratinocyte migration. However, mechanisms regulating keratinocyte migration in the process of cutaneous wound repair remain largely unknown. Here, we found that N-acetyltransferase 10 (NAT10) is essential for cutaneous wound repair in an in vivo skin wound healing model—a significant delay of wound repair in Nat10 haploinsufficient mice and a remarkable inhibition of keratinocyte migration by NAT10 knockdown in an in vitro keratinocyte migration model. We further demonstrate that loss of NAT10 expression attenuates the wound-induced IL-6/IL-8 expression through inhibiting NF-κB/p65 activity in keratinocytes. By deeply digging, silencing NAT10 compromises the level of nuclear p65 by facilitating its poly-ubiquitination, thus accelerates its degradation in the nucleus. Notably, we detected a strong positive correlation between the expression of NAT10 and relevant NF-kB/p65-IL6 signaling activity in mouse wound skin tissues. Overall, our study reveals an important role of NAT10 on cutaneous wound repair by potentiating NF-κB/p65-IL-6/8-STAT3 signaling. Targeting NAT10 might be a potential strategy for the treatment of skin wound dysfunctions and related diseases.
A deep learning framework to emulate density functional theory
Authors: del Rio Beatriz G. , Phan Brandon , Ramprasad Rampi 
Published: August 2023

AbstractDensity functional theory (DFT) has been a critical component of computational materials research and discovery for decades. However, the computational cost of solving the central Kohn–Sham equation remains a major obstacle for dynamical studies of complex phenomena at-scale. Here, we propose an end-to-end machine learning (ML) model that emulates the essence of DFT by mapping the atomic structure of the system to its electronic charge density, followed by the prediction of other properties such as density of states, potential energy, atomic forces, and stress tensor, by using the atomic structure and charge density as input. Our deep learning model successfully bypasses the explicit solution of the Kohn-Sham equation with orders of magnitude speedup (linear scaling with system size with a small prefactor), while maintaining chemical accuracy. We demonstrate the capability of this ML-DFT concept for an extensive database of organic molecules, polymer chains, and polymer crystals.
A nested cohort 5-year Canadian surveillance of Gram-negative antimicrobial resistance for optimized antimicrobial therapy
Authors: Blondeau Joseph , Charles Marthe Kenny , Loo Vivian , Adam Heather , Gonzalez Del Vecchio Marcela , Ghakis Christiane , O’Callaghan Emma , El Ali Radwan 
Published: August 2023

AbstractWe analyzed 5 years (2016–2020) of nested Canadian data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) to identify pathogen predominance and antimicrobial resistance (AMR) patterns of adult Gram-negative infections in Canadian health care and to complement other public surveillance programs and studies in Canada. A total of 6853 isolates were analyzed from medical (44%), surgical (18%), intensive care (22%) and emergency units (15%) and from respiratory tract (36%), intra-abdominal (25%), urinary tract (24%) and bloodstream (15%) infections. Overall, E. coli (36%), P. aeruginosa (18%) and K. pneumoniae (12%) were the most frequent isolates and P. aeruginosa was the most common respiratory pathogen. 18% of Enterobacterales species were ESBL positive. Collective susceptibility profiles showed that P. aeruginosa isolates were highly susceptible (> 95%) to ceftolozane/tazobactam and colistin, though markedly less susceptible (58–74%) to other antimicrobials tested. Multi-drug resistance (MDR) was present in 10% of P. aeruginosa isolates and was more frequent in those from respiratory infections and from ICU than non-ICU locations. Of P. aeruginosa isolates that were resistant to combinations of ceftazidime, piperacillin/tazobactam and meropenem, 73–96% were susceptible to ceftolozane/tazobactam over the period of the study. These national data can now be combined with clinical prediction rules and genomic data to enable expert antimicrobial stewardship applications and guide treatment policies to optimize adult patient care.
Early elevation of high-sensitivity C-reactive protein as a predictor for cardiovascular disease incidence and all-cause mortality: a landmark analysis
Authors: Lee Hye Sun , Lee Jun-Hyuk 
Published: August 2023

AbstractWe investigated the association between early elevation of high-sensitivity C-reactive protein (hsCRP) and cardiovascular disease (CVD) incidence, all-cause mortality, and CVD mortality. We analyzed 6567 participants from the Korean Genome and Epidemiology Study_Ansan_Ansung cohort between 2005 and 2018. The Kaplan–Meier curves and modified Cox regression by Fine and Gray were used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for CVD incidence, all-cause mortality, CVD mortality, cancer mortality, and mortality from other causes. Landmark analyses were performed at the first (2007–2008) and second (2009–2010) follow-up periods, with early elevation defined as hsCRP > 2 mg/L. At the first and second landmark points, the early hsCRP elevation group had a higher incidence of CVD and all-cause mortality. At first landmark point, the adjusted HRs (95% CIs) were 1.37 (1.08–1.74) for incident CVD and 1.26 (1.04–1.53) for all-cause mortality, respectively. At second landmark point, the adjusted HRs in the early hsCRP elevation group were 1.45 (1.12–1.89) for incident CVD and 1.34 (1.10–1.63) for all-cause mortality, respectively. However, there were no significant differences in CVD mortality and cancer mortality between the groups. In conclusion, early elevation of serum hsCRP is a predictor of incident CVD and all-cause mortality. The timing of hsCRP increase is also a significant predictor of incident CVD, even considering the competing risk. Regular hsCRP testing may help monitor hsCRP trends and develop individualized treatment plans for CVD prevention.