bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and associated factors of depressive and anxiety symptoms among healthcare workers in the post-pandemic era of COVID-19 at a tertiary hospital in Shenzhen, China: A cross-sectional study
Authors: Liang Zhiya , Wang Ying , Wei Xiaoyue , Wen Wanyi , Ma Jianping , Wu Jun , Huang Shaofen , Qin Pei 
Published: March 2023

BackgroundHealthcare workers were at high risk of psychological problems during the COVID-19 pandemic, but it remains not well-investigated in the post-pandemic era of COVID-19, with regular epidemic prevention and control embedded in burdened healthcare work. This study aimed to investigate the prevalence and potential risk factors of the symptoms of depression and anxiety among healthcare workers at a tertiary hospital in Shenzhen.MethodOur cross-sectional study was conducted among 21- to 64-year-old healthcare workers in December 2021 at a tertiary hospital in Shenzhen, using a simple random sampling strategy. A wide range of socio-demographic characteristics, individual information, and psychological condition of the subjects were extracted. Healthcare workers' psychological conditions were tested with the Center for Epidemiologic Studies Depression (CESD-10), General Anxiety Disorder (GAD-7), Insomnia Severity Index (ISI), Work-Family Conflict Scale (WFCS), 10-item Connor-Davidson Resilience Scale (CD-RISC-10), and 17-item of Maslach's Burnout Inventory-Human Services Survey (MBI-HSS-17). Data were collected based on these questionnaires. Descriptive statistics were used to assess the difference between healthcare workers with depressive and anxiety symptoms among different groups. Hierarchical logistic regression analyses were conducted to investigate the association between focused variables and mental health outcomes.ResultsA total of 245 healthcare workers were enrolled. The proportion of depressive symptoms, anxiety symptoms and their co-occurrence were 34.7, 59.6, and 33.1%, respectively. Logistic regression showed that for the three outcomes, no history of receiving psychological help and self-rated good or higher health were protective factors, whereas more severe insomnia and job burnout were risk factors. Junior or lower job title and higher psychological resilience were related to a lower prevalence of depressive symptoms, while relatively longer working hours and larger work-family conflict were positively associated with the anxiety symptoms. Psychological resilience was inversely associated with the co-occurrence of depressive and anxiety symptoms.ConclusionsOur study revealed a high proportion of psychological problems and proved that several similar factors which were significant during the pandemic were also associated with the symptoms of depression and anxiety among healthcare workers in the post-pandemic era of COVID-19. These results provide scientific evidence for psychological interventions for healthcare workers.
Therapeutic Targeting of P53: A Comparative Analysis of APR-246 and COTI-2 in Human Tumor Primary Culture 3-D Explants
Authors: Nagourney Adam J. , Gipoor Joshua B. , Evans Steven S. , D’Amora Paulo , Duesberg Max S. , Bernard Paula J. , Francisco Federico , Nagourney Robert A. 
Published: March 2023

Background: TP53 is the most commonly mutated gene in human cancer with loss of function mutations largely concentrated in “hotspots” affecting DNA binding. APR-246 and COTI-2 are small molecules under investigation in P53 mutated cancers. APR binds to P53 cysteine residues, altering conformation, while COTI-2 showed activity in P53 mutant tumors by a computational platform. We compared APR-246 and COTI-2 activity in human tumor explants from 247 surgical specimens. Methods: Ex vivo analyses of programmed cell death measured drug-induced cell death by delayed-loss-of-membrane integrity and ATP content. The LC50s were compared by Z-Score. Synergy was conducted by the method of Chou and Talalay, and correlations were performed by Pearson moment. Results: APR-246 and COTI-2 activity favored hematologic neoplasms, but solid tumor activity varied by diagnosis. COTI-2 and APR-246 activity did not correlate (R = 0.1028) (NS). COTI-2 activity correlated with nitrogen mustard, cisplatin and gemcitabine, doxorubicin and selumetinib, with a trend for APR-246 with doxorubicin. For ovarian cancer, COTI-2 showed synergy with cisplatin at 25%. Conclusions: COTI-2 and APR-246 activity differ by diagnosis. A lack of correlation supports distinct modes of action. Cisplatin synergy is consistent with P53’s role in DNA damage. Different mechanisms of action may underlie disease specificity and offer better disease targeting.
Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1
Authors: Takeda Yoshimichi , Demura Masashi , Kometani Mitsuhiro , Karashima Shigehiro , Yoneda Takashi , Takeda Yoshiyu 
Published: March 2023

Aldosterone and cortisol serve important roles in the pathogenesis of cardiovascular diseases and metabolic disorders. Epigenetics is a mechanism to control enzyme expression by genes without changing the gene sequence. Steroid hormone synthase gene expression is regulated by transcription factors specific to each gene, and methylation has been reported to be involved in steroid hormone production and disease. Angiotensin II or potassium regulates the aldosterone synthase gene, CYP11B2. The adrenocorticotropic hormone controls the 11b-hydroxylase, CYP11B1. DNA methylation negatively controls the CYP11B2 and CYP11B1 expression and dynamically changes the expression responsive to continuous stimulation of the promoter gene. Hypomethylation status of the CYP11B2 promoter region is seen in aldosterone-producing adenomas. Methylation of recognition sites of transcription factors, including cyclic AMP responsive element binding protein 1 or nerve growth factor-induced clone B, diminish their DNA-binding activity. A methyl-CpG-binding protein 2 cooperates directly with the methylated CpG dinucleotides of CYP11B2. A low-salt diet, treatment with angiotensin II, and potassium increase the CYP11B2 mRNA levels and induce DNA hypomethylation in the adrenal gland. A close association between a low DNA methylation ratio and an increased CYP11B1 expression is seen in Cushing’s adenoma and aldosterone-producing adenoma with autonomous cortisol secretion. Epigenetic control of CYP11B2 or CYP11B1 plays an important role in autonomic aldosterone or cortisol synthesis.
Phytochemicals Identification and Bioactive Compounds Estimation of Artemisia Species Grown in Saudia Arabia
Authors: Salih Abdalrhaman M. , Qahtan Ahmed A. , Al-Qurainy Fahad 
Published: March 2023

Artemisia species are very important medicinal plants, particularly in the Middle East and in developing countries. Their products have been used in traditional and medicine contemporary for the treating of infectious ulcers, gangrenous ulcers, inflammations, and malaria. Artemisinin derived from Artemisia species has been used as a drug in many countries for malaria disease treatment. Hence, this study aimed to identify and evaluate the bioactive compounds of three species of Artemisia (Artemisia judaica, Artemisia monosperma, and Artemisia sieberi) growing in Saudi Arabia. Therefore, several analytical techniques, such as gas chromatography–mass spectrometry (GC-MS), UV-Visible spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC), with reference standards, were used. The GC-MS analysis of the artemisia species revealed many bioactive constituents associated with plant secondary metabolites; some of these identified phytochemical components have biological activity. A. Judaica showed the highest number of bioactive compounds, followed by A. sieberi and A. monosperma. Further, the total phenol, total flavonoid, total tannin, terpenoids, and TCA were estimated. Furthermore, biomolecules such gallic acid, tannin acid, quercetin, and artemisinin in different artemisia species were quantified using HPLC with the reference standard. The amount of artemisinin in the leaf extract of these species (A. sieberi, A. Judaica, and A. monosperma) was found to be about 3.01, 2.5, and 1.9 mg/g DW, respectively. Moreover, the antioxidant activity of the samples was estimated. The obtained results have shown that these species possessed high antioxidant activity, and the scavenging of the DPPH radical and hydrogen peroxide were found to be raised with the increase in the plant extract concentration. This reflects the number of bioactive compounds in these species. The findings of this research support and justify the utilization of Artemisia species in folk medicine in the Middle East.
New Taxonomic Arrangement of Dicranella s.l. and Aongstroemia s.l. (Dicranidae, Bryophyta)
Authors: Fedosov Vladimir , Fedorova Alina , Ignatova Elena , Kučera Jan 
Published: March 2023

The recent molecular phylogenetic study of the families Aongstroemiaceae and Dicranellaceae, which resolved the genera Aongstroemia and Dicranella as polyphyletic, indicated the need for changes in their circumscription and provided new morphological evidence to support the formal description of newly recognized lineages. Following up on these results, the present study adds another molecular marker, the highly informative trnK–psbA region, to a subset of previously analyzed taxa and presents molecular data from newly analyzed austral representatives of Dicranella and collections of Dicranella-like plants from North Asia. The molecular data are linked with morphological traits, particularly the leaf shape, tuber morphology, and capsule and peristome characters. Based on this multi-proxy evidence, we propose three new families (Dicranellopsidaceae, Rhizogemmaceae, and Ruficaulaceae) and six new genera (Bryopalisotia, Calcidicranella, Dicranellopsis, Protoaongstroemia, Rhizogemma, and Ruficaulis) to accommodate the described species according to the revealed phylogenetic affinities. Additionally, we amend the circumscriptions of the families Aongstroemiaceae and Dicranellaceae, as well as the genera Aongstroemia and Dicranella. In addition to the monotypic Protoaongstroemia that contains the newly described dicranelloid plant with a 2–3-layered distal leaf portion from Pacific Russia, P. sachalinensis, Dicranella thermalis is described for a D. heteromalla-like plant from the same region. Fourteen new combinations, including one new status change, are proposed.
Nephrotic Syndrome: Could Personalized Therapy Be Possible? A Review
Authors: Длин В.В. , Морозов С.Л. 
Published: March 2023

Термину «персонализированная медицина» чуть более 20 лет, но индивидуальные подходы к терапии пациентов существуют уже более ста лет. Расшифровка генома и развитие фармакогенетики в последние десятилетия открыли новые пути развития медицины и новое понимание понятия «персонализированная медицина». Активное развитие принципов персонализированного подхода к диагностике и лечению в педиатрической нефрологии, особенно с использованием современных молекулярно-генетических методов, не только в разы увеличит диагностические возможности в верификации заболеваний почек, но и позволит определиться с индивидуальной терапией для каждого конкретного ребенка. Это приведет к повышению эффективности лечения, снижению серьезных нежелательных явлений проводимой терапии и существенному улучшению качества жизни, социального и витального прогноза. В статье на примере глюкокортикоидной терапии при нефротическом синдроме у детей продемонстрирована важность изучения генетических факторов, влияющих на индивидуальный фармакодинамический и фармакокинетический профиль глюкокортикостероидов.
The term "personalized medicine" is just over 20 years old, but individual approaches to patient therapy have been around for over a hundred years. Decoding the human genome and pharmacogenetics development in recent decades have opened up new paths for medicine development and a new understanding of the concept of "personalized medicine". An active development of principles for personalized approach to diagnosis and treatment in pediatric nephrology, especially with use of modern molecular genetic methods, would not only multiply diagnostic opportunities in kidney disease verification, but also would allow determining an individual therapy for each particular child. This will lead to improvement of treatment efficacy, to reduction of serious adverse events of therapy applied and to significant improvement of the quality of life and both social and vital prognosis. The article demonstrates the importance of studying genetic factors influencing the individual pharmacodynamic and pharmacokinetic profile of glucocorticosteroids using glucocorticosteroids therapy for nephrotic syndrome in children as an example.
Effect of Climate Change and anthropogenic pressures on the European eel Anguilla anguilla from RAMSAR Wetland Ichkeul Lake: prediction from the Random Forest model
Authors: Sahabni Sabrine , Toujani Rachid , Ben M’Barek Nabiha , Ottaviani Ennio , Riccomagno Eva , Prampolini Enrico , Missaoui Hechmi , Bejaoui Bechir 
Published: March 2023

This study aims to assess the trophic level of Lake Ichkeul and predict the effect of climate change and anthropogenic pressures on European eel using the trophic index TRIX and the Random Forest RF model. The TRIX values show the poor water quality of the lake. While the RF model shows that eel landing depends on water level, turbidity, and salinity. The RF model gave an R2 =58.4% > R2 =40.3% from Multiple linear regression, confirming the high performance of the RF model. The combination of the two models is an appropriate approach to be used in decision making by civil authorities.
PENINGKATAN KOSAKATA DASAR ANAK USIA DINI MELALUI MEDIA FILM ANIMASI PADA KELOMPOK A DI PAUD AR-RIZQI BOGOR
Authors: Nina Nina Yuminar Priyanti , Fadjria O’on 
Published: March 2023

Peningkatan Kosakata Dasar Anak Usia Dini melalui Media Film Animasi pada Kelompok A di Paud Ar-Rizqi Bogor. Universitas Panca Sakti Bekasi
Penelitian ini bertujuan untuk meningkatkan kosakata dasar anak pada usia dini melalui media film animasi pada kelompok A Paud Ar-Rizqi Bogor. Penelitian ini menggunakan Model Penelitian Tindakan Kelas (PTK) dengan dua siklus dan empat tahapan pada setiap siklusnya seperti; perencanaan, pelaksanaan tindakan, observasi, serta refleksi. Subjek pada penelitian ini adalah anak-anak dikelompok A sebanyak 15 anak yaitu 9 anak perempuan dan 6 anak laki-laki.
Pada kondisi awal sebelum dilakukan tindakan dalam meningkatkan kosakata dasar anak diperoleh hasil yang cukup rendah yaitu sekitar 25%. Kemudian setelah dilakukan tindakan pada siklus I menunjikkan peningkatan yaitu sekitar 53% dan meningkat kembali pada siklus II sekitar 80% anak sudah mampu menyebutkan kosakata dasar setelah melihat film animasi.
Hasil penelitian ini menunjukan bahwa media film animasi dapat digunakan dalam upaya peningkatan penguasaan kosakata pada anak. Peningkatan penguasaan kosakata dasar merupakan bagian dari pengembangan bahasa. Melalui bahasa, anak dapat mengartikan pengalaman yang didapatkannya, dan menyampaikan melalui simbol-simbol yang digunakannya untuk berkomunikasi dan berpikir.
Nutrition Knowledge, Attitude, Practice towards Breast Cancer Prevention among the Female Students of University of Hail, Saudi Arabia.
Authors: Shamsuddeen Shahida Banu , Ansari Aisha , Ali Mohammad Shahid 
Published: March 2023

Abstract:
Background: There are limited studies conducted in Saudi Arabia to assess the Nutrition knowledge, attitude, and practice toward the prevention of breast cancer among the female students of Hail University.
Objectives: The purpose of the study was to assess the Nutrition knowledge, attitude, and practice toward breast cancer prevention among university students. The study aims at the following objectives:

To assess the Nutrition knowledge, attitude, and practice towards breast cancer of university students.
To compare the Nutrition knowledge, attitude, and practice (KAP) towards breast cancer between science and non-science students of the university.

Method: A cross-sectional survey was planned to assess nutrition knowledge, attitudes, and practice (KAP) toward breast cancer prevention among students of the University of Hail. The subjects were surveyed through a previously standardized self-administered questionnaire for questions related to nutrition knowledge, attitudes, and practice on the prevention of breast cancer. In addition, self-reported weight and height were collected and body mass index was calculated. The statistical analysis was done using Statistical Package for Social Sciences software (version 18.0).
Results: The general knowledge of nutrition, was self-perceived by the study population. 14.8% of the population perceived that they have a very good knowledge of nutrition, and about 66.7% of the population has an average or good knowledge. From the viewpoint of attitude among the study samples, it was clear that science students have a better attitude when compare to non-science students. The results were statistically significant (P<0/05) for the practice of exercise, consuming fruits and vegetables, and drinking green tea showing a higher number among science students than non-science students.
Conclusion: In conclusion, nutrition KAP towards BC prevention was found to be influenced by factors such as age, the field of study, and the familial history of BC. These results provide further support for the hypothesis that having proper nutritional knowledge improves an individual’s eating practice which will reduce the risk of any nutrition-related cancers such as BC. These findings need to be taken into account when designing breast health education programs. It is suggested to perform successfully design, organize, and implement nutrition education programs in the institutions which will promote the level of knowledge about nutrition, thereby improving their food habits and lifestyle.
Keywords: Nutrition; Knowledge; Attitude; Practice; Lifestyle.
مظاهر التَّشيؤ في الرواية العراقية: رواية (عذراء سنجار) انموذجاً
Authors: م.م دعاء عادل عبد الكريم  
Published: March 2023

التشيؤ مشكلةً إنسانيةً خطيرة تطرق أبواب عصرنا الحديث بعدما تغذَّت جذورها التي انغرست في الماضي على بقايا الممارسات غير الإنسانية القديمة, وصولاً لعصر ما قبل التاريخ من عبودية واحتكار الذَّات وسحق القيم الإنسانية, والدراسات السردية الحديثة شأنها شأن غيرها من العلوم تصدَّت لمناقشة هذه الظواهر, ومنها رواية (عذراء سنجار) التي تحدثت عن أزمة المرأة واغترابها عن الواقع الإنساني والاجتماعي, وتشيؤها الذي جعلها تتحول من كائن يتمتع بالحقوق والحياة السليمة إلى أداة وسلعة شيئية يُنتفع منها لأغراض تُنافي الأخلاق والدين وحقوق الإنسان, فهي رواية مُثقلة بالهموم والانتهاكات الإجرامية التي وقعت على الأيزيديين في العراق بشكل عام والمرأة بشكل خاص أثناء الغزو الداعشي لأراضي سنجار عام 2014, فما وقع عليها كان الأَكثر بشاعة وإهانة للإنسان والإنسانية جمعاء على مر التأريخ, وكان هذا البحث ميداناً للحديث عن مظاهر التشيؤ في رواية (عذراء سنجار) للكاتب العراقي (وارد بدر السالم).
Fitment Assistance and Training For Practices “Sedentary Lifestyle”
Authors: Gumilar Mulya  , Resty Agustryani  , Anggi Setia Lengkana  , Mega Widya Putri  
Published: March 2023

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The purpose of this community service activity is to introduce and provide assistance in efforts to improve physical fitness and design a fitness program for PJOK teachers so that later they can implement it in physical education learning in schools. After analyzing the situation, several problems were identified as follows: (1) There are still PJOK teachers who are not optimal in delivering physical fitness-based physical education materials during the COVID-19 pandemic (2) There is still a lack of knowledge of PJOK teachers about how to form physical fitness programs for students. children, (3) There are still PJOK teachers who tend to focus more on giving assignments, giving monotonous material which causes students to get bored. Therefore, this workshop is a solution for PJOK teachers to try to open scientific horizons regarding physical fitness learning in physical education.
CALCULATION OF THE HEAT EXCHANGERS EFFICIENCY WHEN UTILIZING VENTILATION EMISSIONS FROM INDUSTRIAL PREMISES
Authors: Овчинников А.С. , Жерлыкина М.Н. , Яременко С.А. , Гармонов К.В. 
Published: March 2023

Рассмотрены вопросы энергосбережения в системах вентиляции производственных помещений и котельных жилищно-коммунального хозяйства посредством утилизации теплоты уходящего воздуха. В статье рассматривается методика расчета оптимальных параметров теплообменника по критерию минимального теплового эквивалента для воздушных сред, допустимого значения скорости движения воздуха, эффективности теплообменника. В качестве примера рассматриваются два варианта. Первый вариант - роторный тип теплоутилизатора, в котором имеет место смешивание потоков приточного и удаляемого воздуха в количестве около 5%, что является недопустимым по требованиям пожаровзрывобезопасности для ряда объектов. Второй вариант – пластинчатый теплообменник противоточного типа для демонстрации максимально возможных показателей эффективности, в котором смешивание потоков отсутствует. Выявлено значительное сокращение потребления традиционных ресурсов. Выполнена количественная оценка экономии тепловых ресурсов по месяцам отопительного периода. Показано, что значительное количество тепловой энергии возможно использовать на нужды инженерных систем. Рекомендуется совершенствование методики подбора теплоутилизационного оборудования с учетом содержания вредных веществ в уходящем воздухе и условий пожаровзрывобезопасности в производственном помещении.
We consider the issues of energy saving in the ventilation systems of industrial premises and boiler houses of housing and communal services through the utilization of the heat of the outgoing air. The article discusses the method of calculating the optimal parameters of the heat exchanger by the criterion of the minimum heat equivalent for air media, permissible value of the air velocity and efficiency of the heat exchanger. As an example we consider 2 varieties. The first variant is a rotary type of heat exchanger, in which there is a mixing of supply and exhaust air flows with a quantitative assessment of about 5%, which is unacceptable according to fire and explosion safety requirements for some facilities. The second variant is a plate heat exchanger of a countercurrent type to demonstrate the maximum possible efficiency indicators, in which there is no mixing of flows. We revealed a significant reduction in the consumption of traditional resources. We also performed a quantitative assessment of thermal resources for energy saving by months of the heating period. It is shown that a significant amount of thermal energy can be used for the needs of building engineering systems. It is recommended to improve the methods of selection of heat recovery equipment, taking into account the content of harmful substances in the outgoing air and the conditions of fire and explosion safety in the production room.
Ergonomia e mobilidade: do pioneirismo ao vanguardismo
Authors: Sousa Castro Iara , Banyai Pereira Sándor , Dias Botelho Róber 
Published: March 2023

A ergonomia e a mobilidade sempre estiveram nas bases da pesquisa científica realizada na Escola de Design (ED) da Universidade do Estado de Minas Gerais (UEMG). Investigar estas duas áreas científicas através da óptica do Design é buscar soluções que se orientem pelo o micro e o macro e pela complexidade do ambiente e das interações humanas. Os seres humanos são complexos por natureza e sua relação e interação com o mundo físico, organizacional e virtual estão repletas de desafios. Este trabalho teve como objetivo mapear as diversas contribuições científicas para as áreas de ergonomia e mobilidade trabalhadas no Programa de Pós-graduação em Design. O levantamento realizado abrangeu pesquisas de mestrado concluídas entre 2012 e 2022. O material reunido auxilia no apontamento do vanguardismo na pesquisa envolvendo estas duas áreas do conhecimento, ao mesmo tempo que reforça a tradição da Escola de Design na pesquisa e projetação de soluções voltadas para os desafios relacionados à Ergonomia e a Mobilidade.