bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain learning and performance: a meta-analysis
Authors: Chen Lujie , Jiang Mengqi , Li Taiyu , Jia Fu , Lim Ming K. 
Published: January 2023

PurposeThis paper aims to provide a comprehensive understanding of the supply chain learning (SCL)–performance relationship based on the existing empirical evidence.Design/methodology/approachWe sampled 54 empirical studies on the SCL–performance relationship. We proposed a conceptual research framework and adopted a meta-analytical approach to analyse the SCL–performance relationship.FindingsThe results of the meta-analysis confirm the positive effects of SCL on the performance of both firms and supply chains. In addition, building on the knowledge-based view, we found that learning from customers has a stronger positive effect on performance than does learning from suppliers, while joint learning has a stronger positive effect on performance than does absorptive learning. Business knowledge had a greater effect on performance than did general knowledge, process knowledge or technical knowledge, while explicit knowledge had a stronger effect than tacit knowledge. Moreover, the SCL–performance relationship is moderated by performance measure and industry type but not by regional economic development, highlighting the broad applicability of SCL.Originality/valueThis study is the first meta-analysis on the SCL–performance relationship. It differentiates between learning from customers and learning from suppliers, examines a more comprehensive list of performance measures and tests five moderators to the main effect, significantly contributing to the SCL literature.
Measuring cultural readiness for innovation: six essential questions
Authors: Dobni C. Brooke , Wilson Grant Alexander 
Published: January 2023

Purpose
This paper aims to present a framework that includes six essential factors and four strategic intervention points that provide the necessary context to sustain and support innovation.

Design/methodology/approach
Based on our academic and consulting experience, this article summarizes our knowledge of what it takes to be a top innovator and how organizations should best pursue innovation agendas. The model presented is supported by our research which considers assessments from 3,642 employee responses assessing the innovation cultures of organizations.

Findings
We find that companies need to ask six questions to assess their innovation cultures. These questions relate to creativity, incentives, processes, leadership, knowledge management and resources. Our framework presents four intervention points to support implementing and sustaining an innovation culture including objectives, behaviors and actions, context and management for execution.

Research limitations/implications
Our framework is effective, but we acknowledge that there are other means to creating and sustaining an innovation culture.

Practical implications
We present six questions that companies need to ask themselves to assess their innovation culture and offer strategies to enhance it.

Social implications
Given the contribution of innovation culture to competitiveness and performance, our recommendations will allow managers to set themselves apart from their competition and further their financial and nonfinancial corporate objectives.

Originality/value
Everyone likes the idea of change, but it is the process of change that is difficult. We offer strategies that put such intentions to work.
Futures markets and price stabilisation: An analysis of soybeans markets in North America
Authors: Miljkovic Dragan , Goetz Cole 
Published: January 2023

AbstractThe objective of this paper was to determine whether the futures markets have a stabilising or destabilising impact on soybean's spot prices in North America. Directed acyclic graphs (DAGs) are used to test for causality between futures prices, spot prices and ending stocks, followed by time series econometric analysis. The DAGs point to the two‐way causal link between futures and spot prices and a lack of a causal link between inventory/stocks and spot price volatility. Time series results, including cointegration, vector error correction, impulse response and variance decomposition analysis, indicate a large impact from futures markets on the level and volatility of soybean spot prices in both the short and long run. These results have potentially important implications, as the impact of commodity price volatility is typically asymmetric across different actors. Farmers, for example, unlike speculators, utilise price risk management (PRM) instruments such as futures markets to mitigate price risks and appear to suffer from intensified volatility precisely because of their use of these instruments. Therefore, additional policies to cope with commodity price volatility, such as direct price controls or mitigation of consequences, can have critical stabilising functions supporting farmers' welfare and regional (rural) development.
Do Firms Earn Rents from the Intangible Assets of Their Owners? Institution‐Based Insights from the Energy Sector
Authors: Aliyev Murod , Kafouros Mario 
Published: January 2023

AbstractFirms can earn rents not only from their own intangible assets (FIAs), but also from the intangible assets of their owner organizations (OIAs). Although the literature has established that rent creation from FIAs depends on the quality of institutions, it remains unclear how institutional quality influences rents from OIAs. This study examines how the rents from OIAs and FIAs change when they are deployed in environments with different institutional quality. Combining insights from the resource‐based view and institutional economics, we develop and test a set of predictions using a sample of over 6000 energy firms from 23 European countries. The study shows that the effect of institutional quality on rent creation is asymmetric, being positive for FIAs and negative for OIAs. In addition, OIAs drawn from multiple owners create higher rents than OIAs from a single owner. Such ‘multiplicity‐of‐ownership’ advantages are stronger in countries with better institutional quality. The contribution of the study lies in explaining how the two types of intangible assets generate rents for the focal firm, and in clarifying why the creation of such rents is contingent on the institutional context in which they are deployed.
Camera‐trapping density estimates suggest critically low population sizes for the Wet Tropics subspecies of the spotted‐tailed quoll (Dasyurus maculatus gracilis)
Authors: Rowland Jesse , Hoskin Conrad J. , Burnett Scott 
Published: January 2023

AbstractAccurate estimates of distribution and population density are critical for the management of threatened species. This is particularly pertinent for mammalian predators, whose generally low population density, elusive nature, and large home range requirements make it difficult to detect declines. We aimed to refine population estimates of the northern spotted‐tailed quoll (Dasyurus maculatus gracilis) in the Wet Tropics bioregion, to estimate the total number of adults, the likely size of subpopulations across the known distribution of the subspecies, and its associated conservation status. We performed targeted upland camera‐trapping surveys from June 2017 to May 2019. To calculate population densities, we used a combination of the number of individuals identified from each survey and the mean maximum distance moved from three life history stages. We then extrapolated these estimates to modelled suitable habitat areas, refined by the camera‐trapping surveys. Population sizes for the six defined subpopulations were estimated, and ranged from approximately 5 to 105 individuals. The total population was estimated to be 221 individuals. This total population estimate, and the estimates for each of the subpopulations, are lower than previous published estimates and are cause for concern. Given the low population estimates presented here and unresolved threats driving declines in some subpopulations, we suggest elevation of this subspecies to Critically Endangered under the EPBC Act.
Systematic review with meta‐analysis: Time to diagnosis and the impact of delayed diagnosis on clinical outcomes in inflammatory bowel disease
Authors: Jayasooriya Nishani , Baillie Samantha , Blackwell Jonathan , Bottle Alex , Petersen Irene , Creese Hanna , Saxena Sonia , Pollok Richard C. ,   POP‐IBD study group
Published: January 2023

SummaryBackgroundThe impact of diagnostic delay on the clinical course of inflammatory bowel disease (IBD) remains uncertain.AimTo perform a systematic review of time to diagnosis and the impact of delayed diagnosis on clinical outcomes in Crohn's disease (CD) and ulcerative colitis (UC).MethodsWe searched EMBASE and Medline from inception to 30th November 2022 for studies reporting diagnostic interval, from symptom onset to IBD diagnosis. We calculated the median, interquartile range (IQR) and pooled weighted median, of median diagnostic intervals of eligible studies. We defined delayed diagnosis as individuals above the 75th centile of longest time to diagnosis in each study. Using random effects meta‐analysis, we pooled odds ratios (ORs) with 95% confidence intervals (CI) for studies reporting clinical outcomes, according to delayed diagnosis.ResultsOne hundred and one studies representing 112,194 patients with IBD (CD = 59,359; UC = 52,835) met inclusion criteria. The median of median times to diagnosis was 8.0 (IQR: 5.0–15.2) and 3.7 months (IQR: 2.0–6.7) in CD and UC, respectively. In high‐income countries, this was 6.2 (IQR: 5.0–12.3) and 3.2 months (IQR: 2.2–5.3), compared with 11.7 (IQR: 8.3–18.0) and 7.8 months (IQR: 5.2–21.8) in low‐middle‐income, countries, for CD and UC respectively. The pooled weighted median was 7.0 (95% CI: 3.0–26.4) and 4.6 (95% CI: 1.0–96.0) months, for CD and UC respectively. Eleven studies, representing 6164 patients (CD = 4858; UC = 1306), were included in the meta‐analysis that examined the impact of diagnostic delay on clinical outcomes. In CD, delayed diagnosis was associated with higher odds of stricturing (OR = 1.88; CI: 1.35–2.62), penetrating disease (OR = 1.64; CI: 1.21–2.20) and intestinal surgery (OR = 2.24; CI: 1.57–3.19). In UC, delayed diagnosis was associated with higher odds of colectomy (OR = 4.13; CI: 1.04–16.40).ConclusionDelayed diagnosis is associated with disease progression in CD, and intestinal surgery in both CD and UC. Strategies are needed to achieve earlier diagnosis of IBD.
Prevalence and factors associated with liver fibrosis among first‐degree relatives of Mexican Americans with hepatocellular carcinoma
Authors: Sharpton Suzanne , Shan Kuangda , Bettencourt Ricki , Lee Miryoung , McCormick Joseph B. , Fisher‐Hoch Susan P. , Loomba Rohit 
Published: January 2023

SummaryBackground and AimsWhether hepatocellular carcinoma (HCC) increases the familial risk for hepatic fibrosis has not been thoroughly explored, particularly in Mexican Americans who are disproportionately affected by obesity and metabolic syndrome. We evaluated the risk of significant hepatic fibrosis in first‐degree relatives of Mexican American adults with HCC.MethodsWe performed a cross‐sectional analysis of a prospective cohort of Mexican American probands with HCC and first‐degree relatives enrolled in the Hispanic Liver Cancer Cohort study. We evaluated the prevalence of hepatic fibrosis in first‐degree relatives, defined by liver stiffness measurement (LSM) >= 7.0 kPa with transient elastography (TE). Secondary outcomes included the prevalence of definite hepatic steatosis, defined by controlled attenuation parameter >=288 dB/m.ResultsWe identified 70 probands diagnosed with HCC; 47% were female and the mean age was 62 years (±13 years). Among 112 first‐degree relatives with a mean age of 43 years (±14 years), 19 (17%) had significant fibrosis and 47 (42%) had definite hepatic steatosis, respectively. The prevalence of significant fibrosis was 20% in first‐degree relatives 40 years of age or older. Regression analysis revealed that diabetes (OR 3.2, 95% CI: 1.1–9.2, p = 0.03) and aspartate aminotransferase >=30 units/L (OR 4.0, 95% CI: 1.4–11.7, p = 0.01) were predictors of significant fibrosis in first‐degree relatives.ConclusionsUsing a well‐phenotyped familial cohort, we found that the prevalence of significant fibrosis and definite hepatic steatosis are high in first‐degree relatives of Mexican Americans with HCC, particularly those with diabetes, suggesting that this population may benefit from screening for liver disease.
Perception of smile attractiveness among laypeople and orthodontists regarding the buccal corridor space, as it is defined by the eyes. An innovated technique
Authors: Ntovas Panagiotis , Karkazi Frantzeska , Özbilen Elvan Önem , Flavio Altamiro , Ladia Ourania , Papazoglou Efstratios , Yilmaz Hanife Nuray , Coachman Christian 
Published: January 2023

AbstractObjectiveTo investigate whether there is a relationship between the distance between the iris and pupil with the ideal size of buccal corridors.Materials and MethodsA full‐portrait image of a male Caucasian was used to create a set of 11 digitally modified images with different buccal corridor space. A web‐based cross‐sectional study was designed and distributed via an online survey to 200 laypeople and 200 orthodontists to assess image attractiveness, using a Visual analogue scale. For the statistical analysis, Wilcoxon signed‐rank and Mann–Whitney U tests were used. The significance level was set at p < 0.05.ResultsThe response rate for laypeople was 70% (n = 139), while the rate for orthodontists was 73% (n = 146). For the layperson group, the maximum smile attractiveness score was 10% of buccal width reduction, compared to the iris‐pupillary distance, while for the orthodontists, it was 20%. The attractiveness of the smile was significantly reduced in both groups when the buccal corridor width was increased in comparison to the iris‐pupillary distance.ConclusionThe length between the mesial part of the iris and the distal of the pupil, may constitutes a landmark for the estimation of the desired width of the buccal corridor.Clinical RelevanceInter iris‐pupillary distance can be the starting point in the smile designing process, in order to perform a facial driven selection of buccal corridor size.
Improvement of detection sensitivity of upper gastrointestinal epithelial neoplasia in linked color imaging based on data of eye tracking
Authors: Higashino Masayuki , Ono Shoko , Matsumoto Shogo , Kubo Marina , Yasuura Naohiro , Hayasaka Shuhei , Tanaka Ikko , Shimoda Yoshihiko , Nishimura Yusuke , Ono Masayoshi , Yamamoto Keiko , Ono Yuji , Sakamoto Naoya 
Published: January 2023

AbstractBackground and AimLinked color imaging (LCI) is useful for screening in the gastrointestinal tract; however, its true clinical benefit has not been determined. The aim of this study was to determine the objective advantage of LCI for detection of upper gastrointestinal neoplasms.MethodsNine endoscopists, including three novices, three trainees, and three experts, prospectively performed eye tracking. From 30 cases of esophageal or gastric neoplasm and 30 normal cases without neoplasms, a total of 120 images, including 60 pair images of white light imaging (WLI) and LCI taken at the same positions and angles, were randomly shown for 10 s. The sensitivity of tumor detection as a primary endpoint was evaluated and sensitivities by organ, size, and visual gaze pattern were also assessed. Color differences (ΔE using CIE1976 [L*a*b*]) between lesions and surrounding mucosa were measured and compared with detectability.ResultsA total of 1080 experiments were completed. The sensitivities of tumor detection in WLI and LCI were 53.7% (50.1–56.8%) and 68.1% (64.8–70.8%), respectively (P = 0.002). LCI provided higher sensitivity than WLI for the novice and trainee groups (novice: 42.2% [WLI] vs 65.6% [LCI], P = 0.003; trainee: 54.4% vs 70.0%, P = 0.045). No significant correlations were found between sensitivity and visual gaze patterns. LCI significantly increased ΔE, and the diagnostic accuracy with WLI depended on ΔE.ConclusionsIn conclusion, LCI significantly improved sensitivity in the detection of epithelial neoplasia and enabled epithelial neoplasia detection that is not possible with the small color difference in WLI.(UMIN000047944).
Knee pain as a reason for referral to a paediatric rheumatologist: A retrospective study
Authors: Gorczyca Daiva , Iwańczyk Patrycja , Staś Karolina , Postępski Jacek 
Published: January 2023

AimKnee pain is the most frequently reported type of lower extremity pain among children and adolescents. The objective of this study was to establish the features distinguishing inflammatory knee pain from non‐inflammatory knee pain and to determine the specific variables to consider in suspected juvenile idiopathic arthritis (JIA).MethodsA retrospective chart review was performed among children with knee pain evaluated through paediatric rheumatology consultations at a single centre between 2012 and 2019.ResultsAmong the 262 children, 32 patients (12.2%) were diagnosed with JIA, 46 patients (17.6%) presented with inflammatory knee pain (IP) of an origin different than JIA, and 57 patients (21.7%) with non‐inflammatory knee pain (NIP). In 127 cases (48.5%), no musculoskeletal disorder was diagnosed (NDD). The presence of limping, joint swelling, decreased passive range of motion and decreased active range of motion of the knee joint were registered more frequently in the JIA group compared to the other three groups. Multivariate analysis showed that a family history of autoimmune diseases and pain in other joints were associated with inflammatory pain. Increased pain after physical activity, pain only in the knee joint and absence of limping were predictors of NIP. The risk factors of JIA were limping and an erythrocyte sedimentation range of ≥10 mm after an hour. In the NDD group, the risk factors included no increase in pain after physical activity, serum C‐reactive protein level < 5 mg/L and normal musculoskeletal ultrasound image.ConclusionsThe majority of children with knee pain referred to a paediatric rheumatologist do not have arthritis. Knee pain alone, as a chief complaint, rarely leads to a final JIA diagnosis. Further studies are necessary in order to design the appropriate diagnostic and therapeutic algorithms.
Role of chitosan nanoparticles in combating Fusarium wilt (Fusarium oxysporum f. sp. ciceri) of chickpea under changing climatic conditions
Authors: Sravani Bana , Dalvi Sunil , Narute Tanaji Krishna 
Published: January 2023

AbstractChickpea is the widely consumed dietary legume contributing 18% of global pulse production. Ongoing climatic changes impose several abiotic and biotic stresses on the yield and productivity of chickpeas. Fusarium oxysporum f. sp. ciceris (Foc) is a major soil‐born pathogen which causes up to 100% yield loss. Among the biocontrol strategies to manage the disease problem, the use of chitosan nanoparticles (CNPs) is now emerging as an attractive and beneficial option. CNPs have a major role in mitigating different stress conditions in plants by eliciting a variety of defence responses including pathogen‐related proteins, antioxidants, phytoalexins, proteinase inhibitors, lignin deposition, callose deposition, and so on. This is suggested as an environmentally friendly alternative to chemicals to prevent seed infestation from various pests. It is used as a seed coating agent which acts as a feeding deterrent and barrier to crop pests. Further, chitosan application can mitigate multiple abiotic and biotic stresses. Considering these properties of chitosan will certainly reduce the negative impact of Fusarium on the yield and quality of chickpeas. This review presents an overview of chickpea cultivation, yield losses due to diseases, chitosan application, its derivatives, and mode of action for the management of chickpea wilt in a sustainable manner.
Pregnancy during enzyme replacement therapy with alglucosidase alfa over a 14‐year period in late‐onset Pompe disease
Authors: Yanagihara Chie , Hayasaka Yuki , Kageyama Yasufumi 
Published: January 2023

AbstractWe report a female patient who developed Pompe disease at 15 years old and received enzyme replacement therapy (ERT) from 25 years old. After 14 years of treatment, she became pregnant. ERT was suspended during the organogenic period as a precaution and restarted at 15 weeks' gestation. During the pregnancy, there were no complications or respiratory problems, but transient muscle weakness was observed during the third trimester. The patient gave birth by vaginal delivery at 39 weeks' gestation. Eight months postpartum, her muscle weakness had recovered slowly, and the patient was able to stand up without help.
Optimizing a therapeutic humanized follicle‐stimulating hormone–blocking antibody formulation by protein thermal shift assay
Authors: Sant Damini , Rojekar Satish , Gera Sakshi , Pallapati Anusha R. , Gimenez‐Roig Judit , Kuo Tan‐Chun , Padilla Ashley , Korkmaz Funda , Cullen Liam , Chatterjee Jiya , Shelly Eleanor , Meseck Marcia , Miyashita Sari , Macdonald Anne , Sultana Farhath , Barak Orly , Ryu Vitaly , Kim Se‐Min , Robinson Cemre , Rosen Clifford J. , Caminis John , Lizneva Daria , Haider Shozeb , Yuen Tony , Zaidi Mone 
Published: January 2023

AbstractBiopharmaceutical products are formulated using several Food and Drug Administration (FDA) approved excipients within the inactive ingredient limit to maintain their storage stability and shelf life. Here, we have screened and optimized different sets of excipient combinations to yield a thermally stable formulation for the humanized follicle‐stimulating hormone (FSH)–blocking antibody, MS‐Hu6. We used a protein thermal shift assay in which rising temperatures resulted in the maximal unfolding of the protein at the melting temperature (Tm). To determine the buffer and pH for a stable solution, four different buffers with a pH range from 3 to 8 were screened. This resulted in maximal Tms at pH 5.62 for Fab in phosphate buffer and at pH 6.85 for Fc in histidine buffer. Upon testing a range of salt concentrations, MS‐Hu6 was found to be more stable at lower concentrations, likely due to reduced hydrophobic effects. Molecular dynamics simulations revealed a higher root‐mean‐square deviation with 1 mM than with 100 mM salt, indicating enhanced stability, as noted experimentally. Among the stabilizers tested, Tween 20 was found to yield the highest Tm and reversed the salt effect. Among several polyols/sugars, trehalose and sucrose were found to produce higher thermal stabilities. Finally, binding of recombinant human FSH to MS‐Hu6 in a final formulation (20 mM phosphate buffer, 1 mM NaCl, 0.001% w/v Tween 20, and 260 mM trehalose) resulted in a thermal shift (increase in Tm) for the Fab, but expectedly not in the Fc domain. Given that we used a low dose of MS‐Hu6 (1 μM), the next challenge would be to determine whether 100‐fold higher, industry‐standard concentrations are equally stable.