bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-care access dimensions and ovarian cancer survival: SEER-Medicare analysis of the ORCHiD study
Authors: Montes de Oca Mary Katherine , Chen Quan , Howell Elizabeth , Wilson Lauren E , Meernik Clare , Previs Rebecca A , Huang Bin , Pisu Maria , Liang Margaret I , Ward Kevin C , Schymura Maria J , Berchuck Andrew , Akinyemiju Tomi 
Published: February 2023

AbstractBackgroundRacial and ethnic disparities in ovarian cancer (OC) survival are well-documented. However, few studies have investigated how health-care access (HCA) contributes to these disparities.MethodsTo evaluate the influence of HCA on OC mortality, we analyzed 2008-2015 Surveillance, Epidemiology, and End Results-Medicare data. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between HCA dimensions (affordability, availability, accessibility) and OC-specific and all-cause mortality, adjusting for patient characteristics and treatment receipt.ResultsThe study cohort included 7590 OC patients: 454 (6.0%) Hispanic, 501 (6.6%) Non-Hispanic (NH) Black, and 6635 (87.4%) NH White. Higher affordability (HR = 0.90, 95% CI = 0.87 to 0.94), availability (HR = 0.95, 95% CI = 0.92 to 0.99), and accessibility scores (HR = 0.93, 95% CI = 0.87 to 0.99) were associated with lower risk of OC mortality after adjusting for demographic and clinical factors. Racial disparities were observed after additional adjustment for these HCA dimensions: NH Black patients experienced a 26% higher risk of OC mortality compared with NH White patients (HR = 1.26, 95% CI = 1.11 to 1.43) and a 45% higher risk among patients who survived at least 12 months (HR = 1.45, 95% CI = 1.16 to 1.81).ConclusionsHCA dimensions are statistically significantly associated with mortality after OC and explain some, but not all, of the observed racial disparity in survival of patients with OC. Although equalizing access to quality health care remains critical, research on other HCA dimensions is needed to determine additional factors contributing to disparate OC outcomes by race and ethnicity and advance the field toward health equity.
Communication-based strategies to curb the overuse of low-value cancer screening
Authors: Kim Soela , Monahan Jennifer L , Do Young Kyung 
Published: February 2023

AbstractDrawing upon the theory of reasoned action, the protection motivation theory, and theories of regret, this study proposes and examines three communication strategies to curb the overuse of low-value cancer screening: (a) highlighting negative affective consequences of screening; (b) providing information about diagnostic uncertainty, and (c) using a noncancer disease label. An online survey-based experiment using a 2 (affective message: absent vs. present) × 2 (diagnostic uncertainty information: absent vs. present) × 2 (disease label: thyroid cancer vs. a borderline thyroid neoplasm) full-factorial between-subject design with a control condition was conducted. A total of 612 South Korean women participated. As predicted, the affective message and diagnostic uncertainty information significantly reduced positive attitudes toward screening uptake and anticipated regret regarding screening nonuptake, respectively, thereby reducing screening intention. The noncancer label also reduced screening intention by lowering perceived severity and positive attitude in sequence.
Women, Home, and Alcohol: Constructed Façades and Social Norms in Nineteenth-Century Polish and British Representations of Female Drinking Practices
Authors: Dias-Lewandowska Dorota , Lock Pam 
Published: February 2023

Abstract
Drinking practices are closely connected to human geography. No matter whether we choose to drink in public, private, or secretly, where we drink is closely connected to how and what we drink. Alcohol-related behaviour by women, enacted at home, can undermine or challenge social norms. However, the transgressive nature of drinking could lead to physical exile or the masking of women’s desire for self-determination. We explore how the social construct of the respectable, decent home relied heavily on façades to ‘keep up appearances’. We demonstrate the place of alcohol in building these façades, and revealing them for what they were. Alcohol in this context was much more than a simple relief for women whether they were a stressed entrepreneur, a violent spinster, or a suicidal mistress. The tensions between the actions of the eight figures examined and the expectations of patriarchal culture represented in these façades demonstrate the extent to which society shaped women’s behaviour towards alcohol in Poland and Britain in the second half of the nineteenth century.
Energy transition challenges—traceability and verification
Authors: Taylor Richard 
Published: February 2023

Abstract
The Energy Transition is underway, yet there are real challenges to the endeavour. The necessary, and welcome, incentives offered by governments to speed the transition and encourage innovation rely on a degree of traceability and verification that simply does not exist today, as it has not been necessary or even desirable in traditional hydrocarbon markets to date, save for in the aviation fuels space. Abuses, and even fraud, have already been seen. The challenge of establishing consensus standards, registries and the associated audit trails for the new products and their production is considerable. This article examines some possible solutions, drawing on examples from other sectors such as food and aviation Original Equipment Manufacturers (OEM) spare parts supply.
Setting a just economic value in Indonesia’s biomass program
Authors: Sulistiowati Sulistiowati , Akbar Saiqa I 
Published: February 2023

Abstract
The Indonesian Government has targeted the new and renewable energy mix to achieve a minimum 23 per cent of the total energy use by 2025. Through its State Electricity Company (PLN) a Co-firing Program has been introduced by mixing 5–15 per cent of the biomass into its coal-fired steam power plants to be implemented in 2021 and 2022. However, the program appears to be unattractive for business due to the gap between the price and the highest purchase price regulated by PLN in procuring biomass despite the provision that the arrangement of energy price should represent the principle of just and economic value. This article aims at examining the application of the principle in the biomass Co-firing Program by employing the Energy Justice Theory by Heffron, the Theory of Justice by John Rawls and the Theory of State Intervention by W. Friedmann. It contributes to the literature on energy law by taking the experience of Indonesia because energy law in the country remains underexplored in the literature. At the practical level, this article proposes the direction through which an energy law reform in Indonesia based on the principle of the just economic value could be pursued. In order to make the biomass energy affordable and accessible but still considering the business’ aspects, the government should provide incentive, both fiscal and non-fiscal, to shift the biomass price closer to its just economic value in the form of public legal instruments.
First Report of Peripheral Nerves in Post-Cranial Elements ofCacopsWilliston, 1910, (Temnospondyli: Dissorophidae) from the Lower Permian Richards Spur, Oklahoma
Authors: Armitage Mark H 
Published: February 2023

AbstractPermian bone beds that extend across several states in the US have been known for over 200 years. Those beds have yielded the richest assemblage of the world’s oldest amphibian tetrapod bones in the world. Cacops sp., a well-known amphibian tetrapod from these deposits, has been widely studied, however, no bone histology or bone decalcification has been conducted on these important animals. We report here on the results of decalcification of post-cranial limb elements of Cacops sp., donated by the Sam Nobel Oklahoma Museum of Natural History. Our results include the presence of nerve fibers that display the diagnostic crosshatch pattern known to enclose nerve fascicles and axons, and lipid droplets that exude under cover slip pressure.
A Beginner’s Guide to Dye Selection and Labeling Strategies for Single-Molecule Localization Microscopy
Authors: Gagnon Lauren 
Published: February 2023

AbstractSingle-molecule localization microscopy (SMLM) is an optical super-resolution technique that circumvents the diffraction limit of light by localizing the center point of each fluorophore’s recorded point spread function. SMLM requires the use of labeling strategies and specialized fluorophores and/or buffer conditions that enable most of the fluorophores in the sample to be “turned off” during the experiment so that a sparse subset of the fluorophores in the sample can be isolated from their nearest “on” neighbors and localized to build up an image of interest. Due to the nature of super-resolution single-molecule imaging, careful sample preparation, imaging buffer preparation, and optimized imaging conditions are fundamental requirements for obtaining quality data. This article discusses key factors to consider when preparing samples and acquiring data for SMLM to serve as a starting point for sample preparation and acquisition optimization.
Use of Fish Skin Graft in Management of Combat Injuries Following Military Drone Assaults in Field-Like Hospital Conditions
Authors: Reda Fouad , Kjartansson Hilmar , Jeffery Steven L A 
Published: February 2023

ABSTRACT

Introduction
The 2020 Nagorno-Karabakh war was an armed conflict between Azerbaijan and Armenia over an ethnically and historically significant region. This manuscript is a report on the forward deployment of acellular fish skin graft (FSG) from Kerecis™, a biologic, acellular matrix derived from the skin of wild-caught Atlantic cod that contains intact epidermis and dermis layers. The usual intention of treatment under adverse circumstances is to temporize wounds until better treatment can be attained, although ideally, rapid coverage and treatment are necessary to prevent long-term complications and loss of life and limb. An austere environment, such as the one experienced during the conflict described here, presents considerable logistical barriers for the treatment of wounded soldiers.

Materials and Methods
Dr H. Kjartansson from Iceland and Dr S. Jeffery from the United Kingdom traveled to Yerevan, near the heart of the conflict, to deliver and train on using FSG in wound management. The primary goal was to use FSG in patients where stabilization and improvement in the wound bed were needed before skin grafting. Other goals were to improve healing time, achieve earlier skin grafting, and have better cosmetic outcomes upon healing.

Results
Over the course of two trips, several patients were managed with fish skin. Injuries included large-area full-thickness burn and blast injuries. Management with FSG induced wound granulation several days sooner in all cases, and even weeks in some instances, allowing a stepdown in the reconstruction ladder with earlier skin grafting procedures and a reduction in requirement of flap surgery.

Conclusions
This manuscript describes a successful first instance of forward deployment of FSGs to an austere environment. FSG, in this military context, has shown great portability, with easy transfer of knowledge. More importantly, management with fish skin has shown faster granulation rates in burn wounds for skin grafting, resulting in improved patient outcomes with no documented infections.
AGN candidates in the VVV near-IR galaxy catalogue
Authors: Baravalle Laura D , Schmidt Eduardo O , Alonso M Victoria , Pichel Ana , Minniti Dante , Rodríguez-Kamenetzky Adriana R , Masetti Nicola , Villalon Carolina , Smith Leigh C , Lucas Philip W 
Published: February 2023

ABSTRACTThe goal of this work is to search for Active Galactic Nuclei (AGN) in the Galactic disc at very low latitudes with |b| &lt; 2°. For this, we studied the five sources from the VVV near-infrared (IR) galaxy catalogue that have also WISE counterparts and present variability in the VIrac VAriable Classification Ensemble (VIVACE) catalogue. In the near-IR colour–colour diagrams, these objects have in general redder colours compared to the rest of the sources in the field. In the mid-IR ones, they are located in the AGN region, however, there is a source that presents the highest interstellar extinction and different mid-IR colours to be a young stellar object (YSO). We also studied the source variability using two different statistical methods. The fractional variability amplitude σrms ranges from 12.6 to 33.8, being in concordance with previous results found for type-1 AGNs. The slopes of the light curves are in the range (2.6 − 4.7) × 10−4 mag d–1, also in agreement with results reported on quasars variability. The combination of all these results suggest that four galaxies are type-1 AGN candidates, whereas the fifth source likely a YSO candidate.
p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway
Authors: Zhu Xinxing , Huang Beijia , Zhao Fengting , Lian Jie , He Lixiang , Zhang Yangxia , Ji Longkai , Zhang Jinghang , Yan Xin , Zeng Taoling , Ma Chunya , Liang Yinming , Zhang Chen , Lin Juntang 
Published: February 2023

AbstractNF-κB activates the primary inflammatory response pathway responsible for methicillin-resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we report that the Forkhead box transcription factor FOXN3 ameliorates MRSA-induced pulmonary inflammatory injury by inactivating NF-κB signaling. FOXN3 competes with IκBα for binding to heterogeneous ribonucleoprotein-U (hnRNPU), thereby blocking β-TrCP-mediated IκBα degradation and leading to NF-κB inactivation. FOXN3 is directly phosphorylated by p38 at S83 and S85 residues, which induces its dissociation from hnRNPU, thus promoting NF-κB activation. After dissociation, the phosphorylated FOXN3 becomes unstable and undergoes proteasomal degradation. Additionally, hnRNPU is essential for p38-mediated FOXN3 phosphorylation and subsequent phosphorylation-dependent degradation. Functionally, genetic ablation of FOXN3 phosphorylation results in strong resistance to MRSA-induced pulmonary inflammatory injury. Importantly, FOXN3 phosphorylation is clinically positively correlated with pulmonary inflammatory disorders. This study uncovers a previously unknown regulatory mechanism underpinning the indispensable role of FOXN3 phosphorylation in the inflammatory response to pulmonary infection.
Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis
Authors: Garg Angad , Sanchez Ana M , Miele Matthew , Schwer Beate , Shuman Stewart 
Published: February 2023

AbstractInorganic phosphate is an essential nutrient acquired by cells from their environment. Here, we characterize the adaptative responses of fission yeast to chronic phosphate starvation, during which cells enter a state of quiescence, initially fully reversible upon replenishing phosphate after 2 days but resulting in gradual loss of viability during 4 weeks of starvation. Time-resolved analyses of changes in mRNA levels revealed a coherent transcriptional program in which phosphate dynamics and autophagy were upregulated, while the machineries for rRNA synthesis and ribosome assembly, and for tRNA synthesis and maturation, were downregulated in tandem with global repression of genes encoding ribosomal proteins and translation factors. Consistent with the transcriptome changes, proteome analysis highlighted global depletion of 102 ribosomal proteins. Concomitant with this ribosomal protein deficit, 28S and 18S rRNAs became vulnerable to site-specific cleavages that generated temporally stable rRNA fragments. The finding that Maf1, a repressor of RNA polymerase III transcription, was upregulated during phosphate starvation prompted a hypothesis that its activity might prolong lifespan of the quiescent cells by limiting production of tRNAs. Indeed, we found that deletion of maf1 results in precocious death of phosphate-starved cells via a distinctive starvation-induced pathway associated with tRNA overproduction and dysfunctional tRNA biogenesis.
HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
Authors: Zhang Zhen , Samsa William E , De Yanyan , Zhang Fan , Reizes Ofer , Almasan Alexandru , Gong Zihua 
Published: February 2023

Abstract
The 53BP1-dependent end-joining pathway plays a critical role in double-strand break (DSB) repair. However, the regulators of 53BP1 in chromatin remain incompletely characterized. In this study, we identified HDGFRP3 (hepatoma-derived growth factor related protein 3) as a 53BP1-interacting protein. The HDGFRP3–53BP1 interaction is mediated by the PWWP domain of HDGFRP3 and the Tudor domain of 53BP1. Importantly, we observed that the HDGFRP3–53BP1 complex co-localizes with 53BP1 or γH2AX at sites of DSB and participates in the response to DNA damage repair. Loss of HDGFRP3 impairs classical non-homologous end-joining repair (NHEJ), curtails the accumulation of 53BP1 at DSB sites, and enhances DNA end-resection. Moreover, the HDGFRP3–53BP1 interaction is required for cNHEJ repair, 53BP1 recruitment at DSB sites, and inhibition of DNA end resection. In addition, loss of HDGFRP3 renders BRCA1-deficient cells resistant to PARP inhibitors by facilitating end-resection in BRCA1 deficient cells. We also found that the interaction of HDGFRP3 with methylated H4K20 was dramatically decreased; in contrast, the 53BP1-methylated H4K20 interaction was increased after ionizing radiation, which is likely regulated by protein phosphorylation and dephosphorylation. Taken together, our data reveal a dynamic 53BP1-methylated H4K20–HDGFRP3 complex that regulates 53BP1 recruitment at DSB sites, providing new insights into our understanding of the regulation of 53BP1-mediated DNA repair pathway.
Structure of theCaenorhabditis elegansm6A methyltransferase METT10 that regulates SAM homeostasis
Authors: Ju Jue , Aoyama Tomohiko , Yashiro Yuka , Yamashita Seisuke , Kuroyanagi Hidehito , Tomita Kozo 
Published: February 2023

AbstractIn Caenorhabditis elegans, the N6-methyladenosine (m6A) modification by METT10, at the 3'-splice sites in S-adenosyl-l-methionine (SAM) synthetase (sams) precursor mRNA (pre-mRNA), inhibits sams pre-mRNA splicing, promotes alternative splicing coupled with nonsense-mediated decay of the pre-mRNAs, and thereby maintains the cellular SAM level. Here, we present structural and functional analyses of C. elegans METT10. The structure of the N-terminal methyltransferase domain of METT10 is homologous to that of human METTL16, which installs the m6A modification in the 3'-UTR hairpins of methionine adenosyltransferase (MAT2A) pre-mRNA and regulates the MAT2A pre-mRNA splicing/stability and SAM homeostasis. Our biochemical analysis suggested that C. elegans METT10 recognizes the specific structural features of RNA surrounding the 3'-splice sites of sams pre-mRNAs, and shares a similar substrate RNA recognition mechanism with human METTL16. C. elegans METT10 also possesses a previously unrecognized functional C-terminal RNA-binding domain, kinase associated 1 (KA-1), which corresponds to the vertebrate-conserved region (VCR) of human METTL16. As in human METTL16, the KA-1 domain of C. elegans METT10 facilitates the m6A modification of the 3'-splice sites of sams pre-mRNAs. These results suggest the well-conserved mechanisms for the m6A modification of substrate RNAs between Homo sapiens and C. elegans, despite their different regulation mechanisms for SAM homeostasis.
Acceptability, Feasibility, and Validity of Detecting Respiratory Pathogens During Acute Respiratory Illness in Participant-Collected Swabs in a Low-Income, Community Sample
Authors: Thind Priyam , Vargas Celibell Y , Reed Carrie , Wang Liqun , Alba Luis R , Larson Elaine L , Saiman Lisa , Stockwell Melissa S 
Published: February 2023

AbstractBackgroundCommunity surveillance for acute respiratory illness (ARI) can include unsupervised participant-collected nasal swabs. Little is known about use of self-swabs in low-income populations or among households including extended family members and the validity of self-collected swabs. We assessed the acceptability, feasibility, and validity of unsupervised participant-collected nasal swabs in a low-income, community sample.MethodsThis was a substudy of a larger prospective community-based ARI surveillance study in 405 households in New York City. Participating household members self-collected swabs on the day of a research home visit for an index case, and for 3–6 subsequent days. Demographics associated with agreement to participate and swab collection were assessed, and index case self-collected versus research staff–collected swab results were compared.ResultsMost households (n = 292 [89.6%]) agreed to participate, including 1310 members. Being &lt;18 years old, female, and the household reporter or member of the nuclear family (parents and children) were associated with both agreement to participate and self-swab collection. Being born in the United States or immigrating ≥10 years ago was associated with participation, and being Spanish-speaking and having less than a high school education were associated with swab collection. In all, 84.4% collected at least 1 self-swabbed specimen; self-swabbing rates were highest during the first 4 collection days. Concordance between research staff–collected swabs and self-swabs was 88.4% for negative swabs, 75.0% for influenza, and 69.4% for noninfluenza pathogens.ConclusionsSelf-swabbing was acceptable, feasible, and valid in this low-income, minoritized population. Some differences in participation and swab collection were identified that could be noted by future researchers and modelers.
Higher-level phylogeny and evolutionary history of nonditrysians (Lepidoptera) inferred from mitochondrial genome sequences
Authors: Liao Cheng-Qing , Yagi Sadahisa , Chen Lu , Chen Qi , Hirowatari Toshiya , Wang Xing , Wang Min , Huang Guo-Hua 
Published: February 2023

Abstract
As one of the largest single-radiation sources of phytophagous insects, the higher level phylogeny of lepidopteran lineages has been debated for decades, especially the early divergences of nonditrysia. Here, we use 74 mitochondrial genomes representing seven nonditrysian superfamilies, including the newly sequenced mitochondrial genomes of eight families and 30 species. Four datasets were constructed and used for a phylogenetic analysis based on maximum likelihood (ML) and Bayesian inference (BI) methods. The results reveal that (1) nonditrysian lineages presented typically nested relationships with the family Micropterigidae as the sister-group to the remaining Lepidoptera, (2) monophyly of major clades in Lepidoptera, including Glossata, Heteroneura, Eulepidoptera and Ditrysia, was strongly supported, and (3) Neopseustoidea formed the sister of the remaining Glossata. Divergence-time analysis estimated that Lepidoptera originated c. 222 Mya during the Middle Triassic and that most superfamilies/families of nonditrysia originated from the Early Cretaceous to the Early Palaeogene, which largely coincided with the radiation of angiosperms. Additionally, three novel gene rearrangements in the gene cluster ‘MIQ’ and ‘TP’ were found in nonditrysian groups. Further mitochondrial genome data will help us to better understand the evolution of early nonditrysian lineages.