bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facial authentication based smart door lock system and anomaly detection using machine learning architectures integrated with IoT
Authors: Derbali Morched 
Published: August 2023

Abstract
Home security and reconnaissance, as well as far off entryway exchanging with a hello framework are two parts of this work. Process of installing system's hardware components for security and surveillance begins the user's journey. With advent of Internet of Things (IOT), there is an increase in interest in smart home systems in recent years. One of the significant parts of the brilliant home framework is the security and access control. In this paper, a facial acknowledgment security framework was planned utilizing Raspberry Pi which are consistently coordinated to savvy home framework. Using machine learning architectures and IoT, this study aims to develop a smart door lock (SDL) system based on facial authentication and intrusion detection. Biometric authentication that is based on facial recognition is used to lock this smart door. The distributed encoder Shannon Gaussian Correntropy Bayesian Q-neural networks (DeSGCBQNN) are then used to detect anomalies. The trial examination is completed for different savvy entryway facial dataset as far as accuracy, mean average precision, False Acceptance Rate, False Rejection Rate and mean square error.Proposed technique attained accuracy of 98%, mean average precision of 66%, False Acceptance Rate of 65%, False Rejection Rate 55%and mean square error of 53%.
PI3K-AKT activation resculpts integrin signaling to drive filamentous tau-induced proinflammatory astrogliosis
Authors: Wang Peng , Anderson D. Eric , Ye Yihong 
Published: August 2023

Abstract
Background
Microtubule-binding protein tau is a misfolding-prone protein associated with tauopathies. As tau undergoes cell-to-cell transmission, extracellular tau aggregates convert astrocytes into a pro-inflammatory state via integrin activation, causing them to release unknown neurotoxic factors.
Results
Here, we combine transcriptomics with isotope labeling-based quantitative mass spectrometry analysis of mouse primary astrocyte secretome to establish PI3K-AKT as a critical differentiator between pathogenic and physiological integrin activation; simultaneous activation of PI3K-AKT and focal adhesion kinase (FAK) in tau fibril-treated astrocytes changes the output of integrin signaling, causing pro-inflammatory gene upregulation, trans-Golgi network restructuring, and altered secretory flow. Furthermore, NCAM1, as a proximal signaling component in tau-stimulated integrin and PI3K-AKT activation, facilitates the secretion of complement C3 as a main neurotoxic factor. Significantly, tau fibrils-associated astrogliosis and C3 secretion can be mitigated by FAK or PI3K inhibitors.
Conclusions
These findings reveal an unexpected function for PI3K-AKT in tauopathy-associated reactive astrogliosis, which may be a promising target for anti-inflammation-based Alzheimer’s therapy.
Effect of Risk Factor-tailored Autonomy Enhancement Education in the First-time Middle-aged Patients undergoing Coronary Intervention: A randomized controlled trial
Authors: Uhm In Ae , Hwang Seon Young 
Published: August 2023

Abstract

Purpose
It is important for middle-aged patients who have undergone acute treatment for coronary artery disease to voluntarily improve their lifestyle and risk factors throughout their lives based on their recognition as patients with chronic diseases. This study conducted individual education to improve risk factors and tried to verify its effectiveness.
Methods
The hypothesis was verified by applying a randomized controlled pre- and post-test design through random assignment of two groups. Middle-aged (40–64 years) patients who underwent percutaneous coronary intervention for the first time due to acute myocardial infarction or unstable angina were recruited from a university hospital in Seoul. For the experimental group, based on the Self-Determination Theory, risk factor- tailored counseling and education were provided individually for 1 hour based on the education booklet, and telephone counseling was conducted twice for 12 weeks. The control group was received usual care about risk factor recognition and the need for improvement at the time of discharge. Differences in autonomous motivation, resilience, self-care compliance and biochemical indicators measured after 12 weeks in the experimental group and the control group were compared. Data were analyzed using SPSS/WIN ver. 22.0.
Results
After 12 weeks in the experimental group, autonomous motivation (t = 4.46, p < .001), resilience (t = 7.08, p = .003), and self-care compliance (t = 5.56, p < .001) were significantly higher than those of the control group. Body mass index was also significantly decreased in the experimental group (t=-4.92, p = .005), but there was no significant difference in other biochemical parameters. Among the risk factors, the smoking rate was significantly lower in the experimental group than the control group after intervention (p < .001).
Conclusion
For middle-aged patients with first coronary intervention, risk factor-tailored education emphasizing autonomy by nurses should be provided early after discharge.
Trial registration:
This study was retrospectively registered in the Clinical Research Information Service and the identification number is KCT0008698(11/08/2023).
AI based Inspection of the Axes of Machine Tools Corresponding author: Ibrahim N. Tansel E-Mail: tanseli@fiu.edu
Authors: Demetgul Mustafa , Wang Wei , Fleischer Jürgen , Tansel Ibrahim 
Published: August 2023

Abstract

Linear stages are one of the most important components of machine tools, additive manufacturing equipment, and many machines which are needed to create precise linear motion. Monitoring the current of electric motor has been used for sensorless diagnostic of linear stages. This paper proposed a new Automated Machine Learning (AutoML) approach. The proposed AutoML used multiple methods for interpretation of the current signal to estimate the extent of the misalignment problems. Support Vector Machine (SVM), Gradient Boosting (GB) and Auto-multilayer perceptron (AutoMLP) methods were used for classification of the data. To enhance the performance of these methods Ensemble learning (EL) was used to obtain the final decision by using estimations of each method. Motor current signals in the horizontal and vertical direction were saved in the user interface's database. AutoML learned the proper classification through the user interface which holds data and user interpretations for training and started to make classifications. To improve the classification performance, each hyperparameter was optimized and compared with the initial results. Experimental studies showed that the ensemble method was superior compared to the considered classification methods in fault detection through the motor current signal. The findings indicated that the current features could be used successfully discriminate the signals in the horizontal and vertical directions and could detect linear stage defects. In addition, the results demonstrated that additional fault detection capabilities may be added to the system.
Rates of diagnostic and therapeutic procedures in a cohort of patients undergoing first endocrine consultation for thyroid nodular disease
Authors: Negro Roberto , Greco Gabriele 
Published: August 2023

Abstract
Purpose
This study aimed to evaluate the rates of necessary diagnostic and therapeutic procedures in a cohort of patients undergoing their first endocrine consultation for thyroid nodular disease.
Methods
This was an observational study conducted between January 1 and June 30, 2023, on patients undergoing their first endocrine consultation for thyroid nodular disease. Data were collected, including age, thyroid-stimulating hormone (TSH) concentration, reasons for performing thyroid ultrasound (US), and thyroid US reports. The US was performed at the time of the endocrine consultation according to the American College of Radiology Thyroid Imaging, Reporting and Data System (ACR-TIRADS) risk stratification system. Patients underwent further investigations/treatment or simple US follow-up as necessary.
Results
A total of 373 patients with thyroid nodules were evaluated. Reasons for undergoing thyroid US were unrelated to suspected thyroid disease in 33.8%, incidentalomas in 24.4%, dysfunction or positivity for thyroid antibodies in 18%, symptoms or visible nodules in 16.3%, and family history of thyroid disease in 7.5%. A total of 183 diagnostic or therapeutic procedures were performed in 133 (35.7%) patients [fine-needle aspiration (FNA): 121 (66.1%), surgery: 28 (15.3%), percutaneous ethanol injection: 20 (10.9%), thermal ablation: 7 (3.8%), and radioactive treatment: 7 (3.8%)].
Conclusions
The study results demonstrate that nearly one-third of the patients undergoing their first endocrine consultation for thyroid nodules need diagnostic and therapeutic procedures.
WITHDRAWN: Prospective, multicenter study investigating the acceptance and physiologic effects of a palatable and nutritionally complete food in dogs with malignant cancer
Authors: Becvarova Iveta , Amundson Madison D. , Brejda John , Gross Kathy L. , Anthony Reshma 
Published: August 2023

Abstract

Background Cancer and its treatments can be associated with loss of appetite and poor quality of life (QoL) in dogs. The objective of this single-arm, non-controlled study was to evaluate eating enthusiasm and the nutritional effects of a new food (Hill’s Prescription Diet ON-Care Canine dry) in adult dogs undergoing treatment for malignant cancer. A total of 29 eligible (≥ 1 years old, confirmed diagnosis of malignant cancer, undergoing or recently underwent conventional anticancer therapy, not on any appetite stimulants, and maintaining current medications) dogs were fed the study food for 56 days, with a 7-day transition. Intake (grams, calories), body weight (BW), body condition score (BCS; 1 = very thin, 5 = obese), muscle condition score (MCS; 1 = normal, 4 = severe loss), body fat index (BFI; 20%=low risk, 70%=extreme risk), eating enthusiasm (1 = lowest, 7 = highest), stool quality (1 = liquid, 6 = firm), blood laboratory tests, and QoL were recorded at enrollment and at specific timepoints throughout the 56 days. Results Mean age, BW, BCS, MCS and BFI at Day 0 were 10.1 y, 20.9 kg, 3.2, 1.3 and 27.2%, respectively. Twenty-three of the 29 dogs completed the study. Food (g) and caloric intake measured starting on Day 8 were unchanged throughout the study. However, dogs had a significant increase in BW (1.18 kg, SE 0.30,P = 0.0006) and BFI (3.27%, SE 1.30,P = 0.0193), and improved MCS (–0.18, SE 0.08,P = 0.0375) at Day 56. BCS remained unchanged. Eating enthusiasm remained high throughout the study. QoL assessments were high and remained unchanged except for a significant increase in affection for the family on Day 14 (P = 0.0409). Mean fecal scores ranged between 4.39 and 4.78 throughout the study. Additionally, serum 25 OH-vitamin D significantly increased by 18.1 nmol/L (SE 7.6,P = 0.0257) on Day 56. Conclusions This study demonstrated high acceptance of the study food with significant improvement of muscle condition score and significant increase in serum 25 OH-vitamin D levels, as well as maintained eating enthusiasm and QoL in dogs with malignant cancer. Thus, this new food may provide a favorable nutritional choice for maintaining weight and QoL in dogs with malignant cancer.
Establishment of an in vitro 3D vascularized micro-tumor model and screening of chemotherapeutic drugs
Authors: Ye Qian , Wang Juanru , Wang Boyang , Zhao Min , Wu Zhengsheng , Liu Xiaoli 
Published: August 2023

Abstract
The three-dimensional (3D) cell culture system has received widespread attention in drug discovery, but current 3D culture models have limitations, and a simple and repeatable 3D culture model needs to be developed for high-throughput screening. In this study, we designed an encapsulation device to co-culture MCF-7 cells and HUVE cells in core-shell microcapsules. The formation of vascular lumen was determined by immunohistochemistry and immunofluorescence, and cell proliferation was detected by CCK-8 assay. Anticancer drugs (doxorubicin or paclitaxel) were added 12 hours after the 2D cultured cells were plated or 7 days after the cells grew in the core-shell microcapsules to observe the drug reactions between the models. We found that vascularized micro-tumors were successfully obtained after 14 days of 3D culture. Moreover, our study showed that the proliferation rate of 3D cultured cells was slower than that of 2D cultured cells. In addition, 3D cultured cells were more resistant to anticancer drugs than 2D cultured cells. In this study, we believe that the 3D culture model may provide an available platform for drug screening and is valuable for the study of tumor development and angiogenesis.
Evaluating the Management Trends for Priapism and Assessing the Risk of Priapism After In-office Intracavernosal Injections
Authors: Leong Joon Yau , Prebay Zachary , Ebbott David , Li Michael , Chung Paul 
Published: August 2023

Abstract
We aim to describe the management trends of patients suffering from any priapism, and to evaluate the risks of developing priapism after intracavernosal injections (ICI) performed in the office. We queried TriNetX for two separate male adult cohorts - those who presented with any priapism based on ICD code, N48.3 and those who underwent ICI in the office based on CPT code, 54235. We evaluated treatment options for these patients after any priapism and described demographic risks for developing priapism after ICI performed in office. There were 17,545 priapism encounters and 26,104 usages of ICI in the office. Most common treatment for any priapism was corporal irrigation/injection of medications. The prevalence of prosthesis implants for the acute management of any priapism was low (0.33% malleable, 0.18% inflatable). Patients presenting with priapism after ICI were younger and had a disproportionate prevalence of mood disorders, pain disorders and sickle cell disease. They were less likely to have diabetes, hypertension, prostate cancer or have taken sildenafil or tadalafil. Despite increased exposure, the utility of penile prosthesis placement after priapism remains low. For patients administered and prescribed ICI, proper screening and counseling of developing priapism is important to reduce complications such as erectile dysfunction.
Streptococcus equi Subspecies equi From Strangles Suspected Equines: Molecular Detection, Antibiogram Profiles and Risk Factors
Authors: Bekele Demsew , Desalegn Bereket , Tadesse Belege , Abey Solomon Lulie 
Published: August 2023

Abstract

Strangles, caused by Streptococcus equi subspecies equi, is a highly infectious disease of equines causing major health issues and financial losses. The aim of the study was to detect the presence of the SeM gene in Streptococcus equi isolated from equine suspected of having strangles. A cross-sectional study design was conducted from July to December 2022 in five districts of the central Gondar zone, Ethiopia. One-hundred sixty swap samples were taken from animals that had been clinically suspected. The SeM gene was detected using polymerase chain reaction, and the antimicrobial susceptibility test was performed using the Kirby-Bauer disc diffusion method. The binary logistic regression model was employed to test for statistical significance. In 31.87% (51/160) of the samples, Streptococcus equi species were isolated, and 31.37% (16/51) of these species carried the SeM gene. There was a significant amount of tetracycline (81.5%), erythromycin (81.5%), and vancomycin (75.5%) resistance among the 16 isolates. Strangles were more likely to be present in animals who shared feed containers (AOR = 7.59; 95% CI = 1.44–39.93), drank from the same water troughs (AOR = 7.74; 95% CI = 1.44–41.01), and spent the night together (AOR = 5.97; 95% CI 1.41–25.37). The findings of this study showed that the research areas harboured Streptococcus equi subspecies equi. Sharing feed containers and water troughs were potential sources of strangles infection; thus, these containers need to be cleaned regularly.
CBCT prevalence of MB2 canals in Maxillary molars and its subsequent clinical detection. A comparative clinical study.
Authors: Azim Adham , Alaugaily Ibrahim 
Published: August 2023

Abstract
Objective: The aim of this clinical study was to determine the prevalence of the MB2 canals, factors associated with its radiographic detection using CBCT, and the correlation between CBCT detection and clinically finding these canals.
Materials & Methods: All treatments were completed in the endodontic post-graduate clinic using surgical operating microscopes. Information related to the patient’s age, sex, tooth, treatment type, and type of coronal restoration, were recorded. If MB2 canal was located, this information was recorded together with its canal configuration. If CBCT was acquired before or during treatment, the scans were observed by two board-certified endodontists to determine the radiographic presence or absence of MB2. Fleiss’ Kappa analysis was performed to calculate the inter-observer agreement regarding the presence or absence of MB2 on the CBCT scans. Chi-square, Fisher exact test, and binary logistic regression analyses were performed to establish a correlation between the recorded variables and the ability to locate the MB2 canals clinically and radiographically.
Results:556 maxillary molar teeth met the inclusion criteria. MB2 canals were located in 68.5%. There was no statistically significant difference in the prevalence of MB2 between cases with and without CBCT scans (P>0.05). There was a higher prevalence of MB2 canals, both clinically and radiographically, in male patients, first molars, and retreatment cases (P<0.05). There was no correlation between the patient’s age and observing the MB2 on the scan (P>0.05), However, patients above 60 yrs. of age had a significantly lower clinical prevalence of MB2 (Odds Ratio:2.83; 95% CI 1.28 - 6.23; P= 0.01). The presence of a full coverage restoration did not affect the clinical or radiographic detection of MB2 (P>0.05).
Conclusion: The prevalence of MB2 canals is high among maxillary molar teeth when high magnification is being used, particular among male patients, first molars, and retreatment cases. CBCT has high sensitivity in detecting MB2 canals which can improve the clinician’s certainty to further search for it. However, it did not increase the incidence of locating MB2 canals, particularly in older patients.
Clinical Relevance: MB2 canals may be observed on the CBCT but not all of them will be clinically accessible, particularly in older patients.
Coral Photosymbiosis on Mid-Devonian Reefs
Authors: Jung Jonathan , Zoppe Simon , Söte Till , Moretti Simone , Duprey Nicolas , Foreman Alan , Wald Tanja , Vonhof Hubert , Haug Gerald , Sigman Daniel , Schindler Eberhard , Janussen Dorte , Martinez-Garcia Alfredo 
Published: August 2023

Abstract

The ability of scleractinian corals to thrive in the oligotrophic (low-nutrient, low-productivity) surface waters of the tropical ocean is commonly attributed to their symbiotic relationship with photosynthetic dinoflagellates1,2. The evolutionary history of this symbiosis might clarify its organismal and environmental roles. It is currently unclear whether photosymbiosis first arose in the Triassic, with the emergence of scleractinian corals, or if it was already prevalent amongst older coral groups that have since gone extinct3–5. Here, we report the first measurements of nitrogen isotope ratios of coral-bound organic matter (CB-δ15N) in samples from Mid-Devonian reefs (Givetian, ca. 385 Ma), which represent the oldest isotopic constraint on the evolution of photosymbiosis to date. The colonial tabulate and loosely colonial (dendroid) corals analyzed have low CB-δ15N values (1.59‰±0.53‰ and 1.45±0.66‰, respectively) in comparison with co-occurring solitary rugose corals (4.38‰±1.34‰). The isotopic difference between Devonian colonial and solitary corals (2.86‰±0.86‰) is statistically indistinguishable from that observed between modern symbiont-bearing and symbiont-barren corals (3.38‰±1.05‰). From this evidence we infer that Mid-Devonian colonial tabulate and loosely colonial (dendroid) corals hosted active photosymbionts, while solitary rugose corals did not. The low CB-δ15N values of the Devonian colonial tabulate and dendroid corals relative to the modern range suggest that Devonian reefs formed in biogeochemical regimes analogous to the modern oligotrophic subtropical gyres. Widespread oligotrophy during the Devonian likely may have promoted coral photosymbiosis, potentially explaining why Devonian reefs were the most productive reef ecosystems of the Phanerozoic.
Foliar application of melatonin reduces cadmium uptake and Cd-induced oxidative stress in tobacco under Cd stress
Authors: LV Yi-Ying , Zheng Yuanxian , Wang Jiming , Chen Xiaolong , Ke Yanguo , Huang Feiyan , Liu jiani , He Yuansheng , Zhao Yongteng , Yu lei 
Published: August 2023

Abstract

Melatonin is a well-known signaling molecule in animals and plants. It plays a crucial role in enhancing the antioxidant capacity and resistance of plants to abiotic stresses. This study revealed that the application of exogenous melatonin improved resistance to cadmium (Cd) stress in tobacco, 18 which was reflected through reduction in malondialdehyde and Cd contents and inhibition of tobacco growth. Additionally, melatonin pretreatment controlled Cd-induced oxidative damage to tobacco by directly increasing the photosynthetic efficiency, improving the water absorption capacity, and enhancing antioxidant enzyme activities in cells. Molecular evidence demonstrated that exogenous melatonin-mediated modulation of melatonin synthesis-, antioxidant enzyme synthesis-, and Cd transport-associated genes could cause weakening of Cd toxicity. The transcription levels of six selected genes were further verified through qRT-PCR. This study provides important insights into the molecular mechanism underlying the role of melatonin in Cd stress regulation.
A smartphone-based sensing for portable and sensitive visual detection of Hg (II) via nitrogen doped carbon quantum dots modified paper strip
Authors: Yin Bo , Zhou Rongping , Guo Zhonglong , Sun Jing , Zhu Jihua , Wang Zhenbin , Ma Cunhua , Zhang Mingjin 
Published: August 2023

Abstract
The development of portable and cost-effective sensing system for Hg2+ quantitation is highly demanded for environmental monitoring. Herein, an on-site, rapid and portable smartphone readout device based Hg2+ sensing system integrating nitrogen-doped carbon quantum dots (NCDs) modified paper strip was proposed, and the physicochemical properties of NCDs were characterized by high resolution TEM, FTIR, UV-vis absorption spectrum and fluorescence spectral analysis. The modified paper strip was prepared via “ink-jet” printing technology and exhibits sensitive fluorescence response to Hg2+ with fluorescence color of bright blue (at the excitation/emission wavelength of 365/440 nm). This portable smartphone-based sensing platform is highly selective and sensitive to Hg2+ with the limit of detection (LOD) of 10.6 nM and the concentration range of 0-130 nM. In addition, the recoveries of tap water and local lake water were in the range of 89.4% to 109%. The cost-effective sensing system based on smartphone shows a great potential for trace amounts of Hg2+ monitoring in environmental water samples.