bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Structured Video-Assisted Learning vs Demonstration on Closed Tracheal Suction Among Undergraduate Student Nurses
Authors: Jairus Reena , Naihar Ritu P , Samuel Sangeetha 
Published: September 2023

Background During pandemic only a few sick patients were admitted to the hospital. Hence, for most of the clinical teaching of student nurses, nursing faculty has to be dependent on teaching in the laboratory. The teaching was done either on simulators or by video-assisted teaching instead of the traditional demonstration method. It is imperative to assess the impact of these methods of teaching on the skill of nursing students. Aim To assess the effectiveness of structured video-assisted learning (VAL) vs demonstration of closed tracheal suction (CTS) in developing skill of undergraduate student nurses. Methodology A quasi-experimental, posttest control group design was adopted. A total of 60 undergraduate B.Sc. second-year student nurses (30 in the demonstration and 30 in the VAL group) were enrolled in this study. The tools used were knowledge assessment tool (KAT) on CTS, practice assessment tool (PAT) to assess the knowledge and skill of CTS simultaneously. Google forms with a five-point Likert scale were developed to assess the perception of Students and Faculty regarding VAL on CTS. Results The mean scores of CTS were significantly higher in the demonstration group when compared with the VAL group at P < 0.05. Conclusion Students liked the video, but the demonstration was proved to be a better method to develop the skill in CTS.
Foot and Ankle Soft Tissue Sarcomas–Treatment and Oncologic Outcomes: A Systematic Review of the Literature
Authors: Fanfan Dino , Alvarez Juan C. , Gonzalez Marcos R. , Larios Felipe , Shae Jillian , Pretell-Mazzini Juan 
Published: September 2023

Background: Foot and ankle soft tissue sarcomas (STSs) are rare neoplasms associated with a high risk of local recurrence and metastasis. Although amputation is often performed, its impact on prognosis remains unknown. The aims of our systematic review were identifying risk factors for (1) disease-specific death, (2) local recurrence, (3) metastasis, and assessing (4) whether the type of surgery (amputation or limb-salvage) affected disease-specific survival. Methods: This systematic review was conducted following PRISMA guidelines. The PubMed, Embase, and Scopus databases were searched. Our study was registered in PROSPERO (ID: 415624). Quality appraisal was done using STROBE guidelines. Results: A total of 7 studies and 123 patients were included. Metastasis was the only risk factor for disease-specific death (OR = 107.85, P< .001). Previous unplanned excision (OR = 22.29, P  = .009) and positive margins (OR = 64.48, P  = .011) were associated with higher risk of local recurrence. Patients with high-grade tumors (OR = 13.22, P  = .023) and tumors ≥6 cm (OR = 7.40, P  = .022) were more likely to develop metastases. After adjusting for confounders (age, sex, and presence of metastasis), amputation was not associated with poorer disease-specific survival. Conclusion: Metastasis was the single most important risk factor for death with foot and ankle soft tissue sarcoma. Positive margins and history of previous unplanned excision are risk factors for local recurrence. The most important risk factors for metastasis are tumor grade and size ≥6 cm. Amputation was not associated with poorer disease-specific survival.
Effect of audible static on blood pressure measurement by Doppler ultrasonic sphygmomanometry in cats
Authors: Uematsu Sayaka , Summers Stacie , Keys Deborah , Quimby Jessica 
Published: September 2023

Objectives The aim of the present study was to determine whether the use of headphones to eliminate audible static during Doppler ultrasonic sphygmomanometry affects blood pressure (BP) measurement in conscious young adult (aged 1–6 years) and mature adult/senior (aged ⩾7 years) cats. Methods A randomized crossover study was conducted. Healthy client-owned cats (>1 year) were enrolled. Blood pressure measurements were obtained twice, 14 days apart, with or without the use of headphones worn by a veterinarian. A fear, anxiety and stress (FAS) score (0 = relaxed; 4 = severe signs) was recorded. A linear mixed-effects model was used to compare the effect of wearing headphones on BP measurement. Results In total, 18 young adult and 14 mature adult and senior cats with a median age of 5 years (range 1–14 years) were enrolled. Of the cats, 47% (15/32) had an average BP measurement that was at least 10 mmHg higher when not using headphones compared with using headphones, of which a majority (11/15, 73%) were young adult cats. The average BP measurement was not different when using headphones compared with when not using headphones (mean difference −7 mmHg; 95% confidence interval −14 to 0.6; P = 0.07). When compared within age groups, the average BP measurement taken when using headphones (125 ± 15 mmHg) was lower compared with the measurement taken when not using headphones (137 ± 17 mmHg) in young adult cats ( P = 0.02). Conclusions and relevance The reduction in the average BP measurement with the use of headphones suggests this method may be helpful in reducing situational hypertension, particularly in young adult cats. Our findings also highlight the importance of consistent use of headphones when comparing serial measurements in a cat.
Morphological and radiological features of congenital muscular hypertrophy of the upper limb: experience from a tertiary institution
Authors: Huang Zhifeng , Zhao Junhui , Sun Liying , Zhong Wenyao , Yin Yuehan , Tian Wen 
Published: September 2023

Congenital muscular hypertrophy is a rare overgrowth disorder in the phosphatidylinositol-3-kinase related spectrum. In the past 3 years, ten patients with 11 limbs involved were treated in our centre. The aim of the study was to describe the clinical and radiological deformities of these patients. We documented the characteristic clinical morphological changes, such as hypertrophy, loss of wrist flexion, thumb hyperabduction, finger deviation and skin crease changes in the palm. Radiologically, the mean first metacarpal radial deviation angle of the affected side measured 55° (range 34 to 67) compared to the normal contralateral side 42° (range 32 to 53). The mean intermetacarpal space ratio was 1.2 (range 1.1 to 1.4) and the mean palm width ratio was 1.2 (range 1.1 to 1.3). In this study, we were able to further characterize the radiological and morphological changes of congenital muscular hypertrophy of upper limbs, which would be helpful for establishing the diagnosis and monitor treatment of this rare condition. Level of evidence: IV
Anatomical front and back reconstruction sustains radiographic alignment: a comparison to three-ligament tenodesis
Authors: Yang Brian W. , Victoria Christian , Lee Steve K. , Wolfe Scott W. 
Published: September 2023

Multiple techniques exist to reconstruct the scapholunate interosseous ligament, though none have demonstrated superiority. This study compares 1-year radiographic outcomes of the three-ligament tenodesis and the anatomical front and back reconstruction. All patients who underwent reconstruction of their scapholunate interosseous ligament at one institution with either anatomical front and back reconstruction or three-ligament tenodesis between 2011 and 2020 were retrospectively reviewed. At 52-week follow-up, anatomical front and back reconstruction maintained a statistically significant improvement in scapholunate gap, corrected radiolunate angle and dorsal scaphoid translation, while three-ligament tenodesis demonstrated no sustained improvement in any parameter. The improvement in dorsal scaphoid translation was significantly greater for patients undergoing anatomical front and back reconstruction compared with three-ligament tenodesis at the 16-weeks postoperative timepoint (−1.0 mm, −0.3 mm). Anatomical front and back reconstruction demonstrates sustained improvement in radiographic outcomes at 1 year when compared with three-ligament tenodesis. By addressing both volar and dorsal critical ligament restraints, adoption of anatomical front and back reconstruction for advanced stage scapholunate interosseous ligament injuries should be considered. Level of evidence: IV
The Impact of a Family-Friendly Hospital: A Patient Perspective
Authors: Buchwald Dorte , Buchwald Ditte , Melgaard Dorte 
Published: September 2023

Introduction: When a seriously ill and dying parent is hospitalized, the families are at risk of developing problems. Only sparse evidence is available on the effects of creating family-friendly rooms in hospitals. Aim: This study investigates how a seriously ill parent to children aged 0–18 experiences staying in a hospital room with family-friendly furnishing. Methods: From September 2012 to September 2015, seriously ill and dying patients with children ages 0–18 were offered the opportunity to stay in a family-friendly room at the North Denmark Regional Hospital. The sick parents were interviewed about how the changed room impacted themselves, their children, and their family. Results: The analysis led to three themes: (1) The ability to visit a sick parent, (2) maintaining family functions and relationships, and (3) room for children and adults. Conclusion: By offering the families a hospital room with cozy furniture and a big TV screen, seriously ill parents see that their children are more comfortable when visiting the hospital. A family-friendly hospital is not just an idealistic thought, it is a real opportunity to improve the final period of a dying parent’s life.
Heterogeneous Characteristics of the CD90+ Progenitors in the Fibrocartilage of Different Joints
Authors: Wang Yiru , Li Qianli , Li Haohan , Yang Xianni , Fang Han , Bi Ruiye , Zhu Songsong 
Published: September 2023

Objective This study aimed to isolate and compare the mesenchymal stem cell characteristics of CD90+ cells from different fibrocartilage tissues in the temporomandibular joint (TMJ), the knee joint, and the intervertebral joint to further understand the similarities and differences of these 4 fibrocartilage tissues. Methods CD90+ cells were isolated from TMJ disc, condylar cartilage, meniscus, and intervertebral disc by using magnetic-activated cell sorting. Cellular assays including 4.5-ethynyl-2′-deoxyuridine labeling, multilineage differentiation, colony formation, and cell migration were conducted to compare their mesenchymal stem cell characteristics. Immunofluorescent staining was performed for observing the expression of actively proliferating CD90+ cells within the tissues. H&E staining and Safranine O staining were used to compare the histological features. Results The CD90+ cells derived from these 4 fibrocartilage tissues exhibited comparable cell proliferation abilities. However, the cells from the TMJ disc displayed limited multilineage differentiation potential, colony formation, and cell migration abilities in comparison with the cells from the other fibrocartilage tissues. In vivo, there was relatively more abundant expression of CD90+ cells in the TMJ disc during the early postnatal stage. The limited EDU+ cell numbers signified a low proliferation capacity of CD90+ cells in the TMJ disc. In addition, we observed a significant decrease in cell density and a restriction in the synthesis of extracellular proteoglycans in the TMJ disc. Conclusion Our study highlights the spatial heterogeneity of CD90+ cells in the fibrocartilages of different joint tissues, which may contribute to the limited cartilage repair capacity in the TMJ disc.
Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm
Authors: Chi Xiao-jv , Song Yi-bei , Liu Deng-he , Wei Li-qiang , An Xin , Feng Zi-zhen , Lan Xiao-hua , Lan Dong , Huang Chao 
Published: September 2023

Background Although surgical methods are the most effective treatments for colon adenocarcinoma (COAD), the cure rates remain low, and recurrence rates remain high. Furthermore, platelet adhesion-related genes are gaining attention as potential regulators of tumorigenesis. Therefore, identifying the mechanisms responsible for the regulation of these genes in patients with COAD has become important. The present study aims to investigate the underlying mechanisms of platelet adhesion-related genes in COAD patients. Methods The present study was an experimental study. Initially, the effects of platelet number and related genomic alteration on survival were explored using real-world data and the cBioPortal database, respectively. Then, the differentially expressed platelet adhesion-related genes of COAD were analyzed using the TCGA database, and patients were further classified by employing the non-negative matrix factorization (NMF) analysis method. Afterward, some of the clinical and expression characteristics were analyzed between clusters. Finally, least absolute shrinkage and selection operator regression analysis was used to establish the prognostic nomogram. All data analyses were performed using the R package. Results High platelet counts are associated with worse survival in real-world patients, and alternations to platelet adhesion-related genes have resulted in poorer prognoses, based on online data. Based on platelet adhesion-related genes, patients with COAD were classified into two clusters by NMF-based clustering analysis. Cluster2 had a better overall survival, when compared to Cluster1. The gene copy number and enrichment analysis results revealed that two pathways were differentially enriched. In addition, the differentially expressed genes between these two clusters were enriched for POU6F1 in the transcription factor signaling pathway, and for MATN3 in the ceRNA network. Finally, a prognostic nomogram, which included the ALOX12 and ACTG1 genes, was established based on the platelet adhesion-related genes, with a concordance (C) index of 0.879 (0.848–0.910). Conclusion The mRNA expression-based NMF was used to reveal the potential role of platelet adhesion-related genes in COAD. The series of experiments revealed the feasibility of targeting platelet adhesion-associated gene therapy.
The Burden of Revision Total Ankle Replacement Has Increased From 2010 to 2020
Authors: Ratnasamy Philip P. , Maloy Gwyneth C. , Oghenesume Oghenewoma P. , Peden Sean C. , Grauer Jonathan N. , Oh Irvin 
Published: September 2023

Background: Total ankle replacement (TAR) surgery has increased in recent decades. The aim of this study was to investigate the evolving burden of revision surgery and risk factors and timing of revision or explant. Methods: Using the 2010 to 2020 PearlDiver M151Ortho data set, this retrospective cohort study identified primary TAR, TAR revision, and TAR explant patients via Current Procedural Terminology ( CPT) and International Classification of Disease Procedural ( ICD-P) codes. This database contains billing claims information across all payers and sites of care in the United States. Patient factors investigated included age, sex, and Elixhauser Comorbidity Index (ECI). Annual incidence for primary TAR was normalized per 100 000 covered lives in the data set for each year of study and recorded. Annual incidence of revision TAR and explant were normalized per 100 TARs performed for each year of study. Multivariate logistic regression analyses were performed to determine independent risk factors for revision TAR or explant. For explants, the eventual intervention by 2 years was analyzed. Ten-year timing and survival to revision or explant surgery following unilateral TAR were characterized. Results: A total of 10 531 primary, 1218 revision, and 1735 explant TARs were identified. After normalization, TAR utilization increased by 284% from 2010 to 2020, annual TAR revisions rose 28%, and annual TAR explants decreased 65%. Independent predictors of revision TAR were younger age (odds ratio [OR] 1.29 per decade decrease) and higher ECI (OR 1.23 per 2-point increase). Independent predictors of explant included younger age (OR 1.80 per decade decrease), female sex (OR 1.17), and higher ECI (OR 1.35 per 2-point increase). The 10-year implant survival rate was 91.8%, of which 73% of revisions and 83% of explants occurred in the first 3 years following index TAR. Conclusion: TAR utilization has grown substantially over the past decade, with minimal increases in the annual rate of revision surgery with respect to index procedures performed. Level of Evidence: Level III, retrospective cohort study.
Implementation of interventions to maintain and promote the functional mobility of nursing home residents – a scoping review
Authors: Quasdorf Tina , Manietta Christina , Rommerskirch-Manietta Mike , Braunwarth Jana Isabelle , Roßmann Christin , Roes Martina 
Published: September 2023

Abstract
Background
To provide an overview of the available evidence on the implementation of direct and capacity-building interventions to promote and maintain the functional mobility of nursing home residents.

Methods
We conducted a scoping review following the methodological guidance for the conduct of scoping reviews as described by the Joanna Briggs Institute. We searched for studies in MEDLINE (via PubMed) and CINAHL (via EBSCO). We conducted a qualitative content analysis of the included studies with deductive categories based on the Consolidated Framework for Implementation Research (CFIR).

Results
Ultimately, we included 8 studies on direct interventions, 6 studies on capacity-building interventions, and 2 studies on both types of interventions in our review. Seven studies provided evidence on implementation strategies comprising discrete as well as multifaceted, multilevel strategies. Most of the studies did not systematically evaluate the strategies but remained at a descriptive level. All 16 studies provided evidence of influencing factors. We identified 32 of the 37 influencing factors of the CFIR. The five most frequent influencing factors were available resources (n = 14), access to knowledge and information (n = 12), patient needs and resources (n = 10), knowledge and beliefs about the intervention (n = 10) and compatibility (n = 9).

Conclusions
The available evidence on the implementation of functional mobility interventions in nursing homes is rather limited. This emphasizes the need for further research. Regarding implementation strategies, the systematic evaluation and further development of the reported promising approaches might be a starting point.
A scoping review of media campaign strategies used to reach populations living with or at high risk for Hepatitis C in high income countries to inform future national campaigns in the United Kingdom
Authors: Etoori David , Desai Monica , Mandal Sema , Rosenberg William , Sabin Caroline A 
Published: September 2023

Abstract
Background
With the advent of direct acting antivirals, the World Health Organisation proposed eliminating Hepatitis C as a public health threat by 2030. To achieve this, countries need to diagnose, engage in care and treat their undiagnosed populations. This will require sensitisation campaigns. However previous media campaigns have had mixed impact. We conducted a scoping review to identify and understand the impact of previous Hepatitis C media campaigns. These findings could inform the delivery of future campaigns.

Methods
We searched five electronic databases for published literature on media campaigns conducted for Hepatitis C awareness, testing, and treatment in Organisation for Economic Co-operation and Development (OECD) countries since 2010. Two independent reviewers screened citations for inclusion. Additionally, we spoke to stakeholders in the Hepatitis C field in the UK and conducted a Google search to identify any unpublished literature. A quantitative synthesis was conducted to identify targeted populations, strategies and media used, aims and impact of the campaigns.

Results
A title and year of publication screening of 3815 citations resulted in 113 papers that had a full abstract screen. This left 50 full-text papers, 18 were included of which 9 (50%) were from Europe. 5 (27.8%) of campaigns targeted minority ethnicities, and 9 (50%) aimed to increase testing. A Google search identified 6 grey literature sources. Most campaigns were not evaluated for impact. Discussions with stakeholders identified several barriers to successful campaigns including lack of targeted messaging, stigmatising or accusatory messaging, and short-lived or intermittent campaign strategies.

Conclusion
Future campaigns will likely need to be multifaceted and have multiple tailored interventions. Campaigns will need to be sizeable and robust, integrated into health systems and viewed as an ongoing service rather than one-offs.
Etiological analysis of infection after CRS + HIPEC in patients with PMP
Authors: Yang Rui , Zhao Xin , Fu Yu-Bin , Lin Yu-Lin , Ma Ru , Su Yan-Dong , Wu He-Liang , Liang Xin-Li , Li Yan 
Published: September 2023

Abstract
Background
Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) is the standard treatment for pseudomyxoma peritonei (PMP). It can significantly prolong the survival of patients, but at the same time may increase the risk of postoperative infection.

Method
Patients with PMP who underwent CRS + HIPEC at our center were retrospectively analyzed. According to PMP patients, basic clinical data and relevant information of postoperative infection, we analyzed the common sites of postoperative infection, results of microbial culture and the antibiotics sensitivity. Univariate and multivariate analysis were performed to explore infection-related risk factors.

Result
Among the 482 patients with PMP, 82 (17.0%) patients were infected after CRS + HIPEC. The most common postoperative infection was central venous catheter (CVC) infection (8.1%), followed by abdominal-pelvic infection (5.2%). There were 29 kinds of microbes isolated from the culture (the most common was Staphylococcus epidermidis), including 13 kinds of Gram-positive bacteria, 12 kinds of Gram-negative bacteria, and 4 kinds of funguses. All the antibiotics sensitivity results showed that the most sensitive antibiotics were vancomycin to Gram-positive bacteria (98.4%), levofloxacin to Gram-negative bacteria (68.5%), and fluconazole to fungus (83.3%). Univariate and multivariate analysis revealed the infection independent risk factors as follow: intraoperative blood loss ≥ 350 mL (P = 0.019), ascites volume ≥ 300 mL (P = 0.008).

Conclusion
PMP patients may have increased infection risk after CRS + HIPEC, especially CVC, abdominal-pelvic and pulmonary infections. The microbial spectrum and antibiotics sensitivity results could help clinicians to take prompt prophylactic and therapeutic approaches against postoperative infection for PMP patients.