bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authigenic and Detrital Carbonate Nd Isotope Records Reflect Pulses of Detrital Material Input to the Labrador Sea During the Heinrich Stadials
Authors: Filippova Alexandra , Frank Martin , Kienast Markus , Gutjahr Marcus , Hathorne Ed C. , Hillaire‐Marcel Claude 
Published: January 2023

AbstractLimited constraints on the variability of the deep‐water production in the Labrador Sea complicate reconstructions of the strength of the Atlantic Meridional Overturning Circulation (AMOC) during the Late Quaternary. Large volumes of detrital carbonates were repeatedly deposited in the Labrador Sea during the last 32 kyr, potentially affecting radiogenic Nd isotope signatures. To investigate this the Nd isotope compositions of deep and intermediate waters were extracted from the authigenic Fe‐Mn oxyhydroxide fraction, foraminiferal coatings, the residual silicates and leachates of dolostone grains. We provide a first order estimation of Nd release via dissolution of detrital carbonates and its contribution to the authigenic ԑNd signatures in the Labrador Sea. During the Last Glacial Maximum the Nd isotope signatures in the Labrador Sea would allow active water mass mixing with more radiogenic ɛNd values (−12.6 and −14) prevailing in its eastern part whereas less radiogenic values (ɛNd ∼ −18.4) were found on the western Labrador slope. The deposition of detrital carbonates during Heinrich stadials (2,1) was accompanied by negative detrital and authigenic Nd isotope excursions (ɛNd ∼ −31) that were likely controlled by dissolution of dolostone or dolostone associated mineral inclusions. This highly unradiogenic signal dominated the authigenic phases and individual water masses in the Labrador Sea, serving as potential source of highly unradiogenic Nd to the North Atlantic region, while exported southward. The Holocene authigenic ɛNd signatures of the coatings and leachates significantly differed from those of the detrital silicates, approaching modern bottom water mass signatures during the Late Holocene.
Integrated sensing and communication in an optical fibre
Authors: He Haijun , Jiang Lin , Pan Yan , Yi Anlin , Zou Xihua , Pan Wei , Willner Alan E. , Fan Xinyu , He Zuyuan , Yan Lianshan 
Published: January 2023

AbstractThe integration of high-speed optical communication and distributed sensing could bring intelligent functionalities to ubiquitous optical fibre networks, such as urban structure imaging, ocean seismic detection, and safety monitoring of underground embedded pipelines. This work demonstrates a scheme of integrated sensing and communication in an optical fibre (ISAC-OF) using the same wavelength channel for simultaneous data transmission and distributed vibration sensing. The scheme not only extends the intelligent functionality for optical fibre communication system, but also improves its transmission performance. A periodic linear frequency modulation (LFM) light is generated to act as the optical carrier and sensing probe in PAM4 signal transmission and phase-sensitive optical time-domain reflectometry (Φ-OTDR), respectively. After a 24.5 km fibre transmission, the forward PAM4 signal and the carrier-correspondence Rayleigh backscattering signal are detected and demodulated. Experimental results show that the integrated solution achieves better transmission performance (~1.3 dB improvement) and a larger launching power (7 dB enhancement) at a 56 Gbit/s bit rate compared to a conventional PAM4 signal transmission. Meanwhile, a 4 m spatial resolution, 4.32-nε/$$\sqrt {Hz}$$

H
z

strain resolution, and over 21 kHz frequency response for the vibration sensing are obtained. The proposed solution offers a new path to further explore the potential of existing or future fibre-optic networks by the convergence of data transmission and status sensing. In addition, such a scheme of using shared spectrum in communication and distributed optical fibre sensing may be used to measure non-linear parameters in coherent optical communications, offering possible benefits for data transmission.
2D Titanium carbide printed flexible ultrawideband monopole antenna for wireless communications
Authors: Zhao Weiwei , Ni Hao , Ding Chengbo , Liu Leilei , Fu Qingfeng , Lin Feifei , Tian Feng , Yang Pin , Liu Shujuan , He Wenjun , Wang Xiaoming , Huang Wei , Zhao Qiang 
Published: January 2023

AbstractFlexible titanium carbide (Ti3C2) antenna offers a breakthrough in the penetration of information communications for the spread of Internet of Things (IoT) applications. Current configurations are constrained to multi-layer complicated designs due to the limited conformal integration of the dielectric substrate and additive-free Ti3C2 inks. Here, we report the flexible ultrawideband Ti3C2 monopole antenna by combining strategies of interfacial modification and advanced extrusion printing technology. The polydopamine, as molecular glue nano-binder, contributes the tight adhesion interactions between Ti3C2 film and commercial circuit boards for high spatial uniformity and mechanical flexibility. The bandwidth and center frequency of Ti3C2 antenna can be well maintained and the gain differences fluctuate within ±0.2 dBi at the low frequency range after the bent antenna returns to the flat state, which conquers the traditional inelastic Cu antenna. It also achieves the demo instance for the fluent and stable real-time wireless transmission in bending states.
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
Authors: Han Xuexiang , Gong Ningqiang , Xue Lulu , Billingsley Margaret M. , El-Mayta Rakan , Shepherd Sarah J. , Alameh Mohamad-Gabriel , Weissman Drew , Mitchell Michael J. 
Published: January 2023

AbstractLipid nanoparticle-mediated RNA delivery holds great potential to treat various liver diseases. However, targeted delivery of RNA therapeutics to activated liver-resident fibroblasts for liver fibrosis treatment remains challenging. Here, we develop a combinatorial library of anisamide ligand-tethered lipidoids (AA-lipidoids) using a one-pot, two-step modular synthetic method and adopt a two-round screening strategy to identify AA-lipidoids with both high potency and selectivity to deliver RNA payloads to activated fibroblasts. The lead AA-lipidoid AA-T3A-C12 mediates greater RNA delivery and transfection of activated fibroblasts than its analog without anisamide and the FDA-approved MC3 ionizable lipid. In a preclinical model of liver fibrosis, AA-T3A-C12 enables ~65% silencing of heat shock protein 47, a therapeutic target primarily expressed by activated fibroblasts, which is 2-fold more potent than MC3, leading to significantly reduced collagen deposition and liver fibrosis. These results demonstrate the potential of AA-lipidoids for targeted RNA delivery to activated fibroblasts. Furthermore, these synthetic methods and screening strategies open a new avenue to develop and discover potent lipidoids with targeting properties, which can potentially enable RNA delivery to a range of cell and tissue types that are challenging to access using traditional lipid nanoparticle formulations.
BMI-adjusted adipose tissue volumes exhibit depot-specific and divergent associations with cardiometabolic diseases
Authors: Agrawal Saaket , Klarqvist Marcus D. R. , Diamant Nathaniel , Stanley Takara L. , Ellinor Patrick T. , Mehta Nehal N. , Philippakis Anthony , Ng Kenney , Claussnitzer Melina , Grinspoon Steven K. , Batra Puneet , Khera Amit V. 
Published: January 2023

AbstractFor any given body mass index (BMI), individuals vary substantially in fat distribution, and this variation may have important implications for cardiometabolic risk. Here, we study disease associations with BMI-independent variation in visceral (VAT), abdominal subcutaneous (ASAT), and gluteofemoral (GFAT) fat depots in 40,032 individuals of the UK Biobank with body MRI. We apply deep learning models based on two-dimensional body MRI projections to enable near-perfect estimation of fat depot volumes (R2 in heldout dataset = 0.978-0.991 for VAT, ASAT, and GFAT). Next, we derive BMI-adjusted metrics for each fat depot (e.g. VAT adjusted for BMI, VATadjBMI) to quantify local adiposity burden. VATadjBMI is associated with increased risk of type 2 diabetes and coronary artery disease, ASATadjBMI is largely neutral, and GFATadjBMI is associated with reduced risk. These results – describing three metabolically distinct fat depots at scale – clarify the cardiometabolic impact of BMI-independent differences in body fat distribution.
Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation
Authors: Lin Wanzun , Chen Li , Zhang Haojiong , Qiu Xianxin , Huang Qingting , Wan Fangzhu , Le Ziyu , Geng Shikai , Zhang Anlan , Qiu Sufang , Chen Long , Kong Lin , Lu Jiade J. 
Published: January 2023

AbstractThe recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response. YTHDF1 is a versatile and powerful m6A reader, but the understanding of its impact on immune evasion is limited. Here, we reveal that tumor-intrinsic YTHDF1 drives immune evasion and immune checkpoint inhibitor (ICI) resistance. Additionally, YTHDF1 deficiency converts cold tumors into responsive hot tumors, which improves ICI efficacy. Mechanistically, YTHDF1 deficiency inhibits the translation of lysosomal genes and limits lysosomal proteolysis of the major histocompatibility complex class I (MHC-I) and antigens, ultimately restoring tumor immune surveillance. In addition, we design a system for exosome-mediated CRISPR/Cas9 delivery to target YTHDF1 in vivo, resulting in YTHDF1 depletion and antitumor activity. Our findings elucidate the role of tumor-intrinsic YTHDF1 in driving immune evasion and its underlying mechanism.
Reconciling discrepant minor sulfur isotope records of the Great Oxidation Event
Authors: Uveges Benjamin T. , Izon Gareth , Ono Shuhei , Beukes Nicolas J. , Summons Roger E. 
Published: January 2023

AbstractUnderstanding the timing and trajectory of atmospheric oxygenation remains fundamental to deciphering its causes and consequences. Given its origin in oxygen-free photochemistry, mass-independent sulfur isotope fractionation (S-MIF) is widely accepted as a geochemical fingerprint of an anoxic atmosphere. Nevertheless, S-MIF recycling through oxidative sulfide weathering—commonly termed the crustal memory effect (CME)—potentially decouples the multiple sulfur isotope (MSI) record from coeval atmospheric chemistry. Herein, however, after accounting for unrecognised temporal and spatial biases within the Archaean–early-Palaeoproterozoic MSI record, we demonstrate that the global expression of the CME is barely resolvable; thereby validating S-MIF as a tracer of contemporaneous atmospheric chemistry during Earth’s incipient oxygenation. Next, utilising statistical approaches, supported by new MSI data, we show that the reconciliation of adjacent, yet seemingly discrepant, South African MSI records requires that the rare instances of post-2.3-billion-year-old S-MIF are stratigraphically restricted. Accepting others’ primary photochemical interpretation, our approach demands that these implied atmospheric dynamics were ephemeral, operating on sub-hundred-thousand-year timescales. Importantly, these apparent atmospheric relapses were fundamentally different from older putative oxygenation episodes, implicating an intermediate, and potentially uniquely feedback-sensitive, Earth system state in the wake of the Great Oxidation Event.
Suppressing non-radiative recombination in metal halide perovskite solar cells by synergistic effect of ferroelasticity
Authors: Qin Wei , Ali Wajid , Wang Jianfeng , Liu Yong , Yan Xiaolan , Zhang Pengfei , Feng Zhaochi , Tian Hao , Yin Yanfeng , Tian Wenming , Li Can 
Published: January 2023

AbstractThe low fraction of non-radiative recombination established the foundation of metal halide perovskite solar cells. However, the origin of low non-radiative recombination in metal halide perovskite materials is still not well-understood. Herein, we find that the non-radiative recombination in twinning-tetragonal phase methylammonium lead halide (MAPbIxCl3-x) is apparently suppressed by applying an electric field, which leads to a remarkable increase of the open-circuit voltage from 1.12 V to 1.26 V. Possible effects of ionic migration and light soaking on the open-circuit voltage enhancement are excluded experimentally by control experiments. Microscopic and macroscopic characterizations reveal an excellent correlation between the ferroelastic lattice deformation and the suppression of non-radiative recombination. The calculation result suggests the existence of lattice polarization in self-stabilizable deformed domain walls, indicating the charge separation that facilitated by lattice polarization is accountable for the suppressed non-radiative recombination. This work provides an understanding of the excellent performance of metal halide perovskite solar cells.
An iron-base oxygen-evolution electrode for high-temperature electrolyzers
Authors: Du Kaifa , Gao Enlai , Zhang Chunbo , Ma Yongsong , Wang Peilin , Yu Rui , Li Wenmiao , Zheng Kaiyuan , Cheng Xinhua , Tang Diyong , Deng Bowen , Yin Huayi , Wang Dihua 
Published: January 2023

AbstractHigh-temperature molten-salt electrolyzers play a central role in metals, materials and chemicals production for their merit of favorable kinetics. However, a low-cost, long-lasting, and efficient high-temperature oxygen evolution reaction (HT-OER) electrode remains a big challenge. Here we report an iron-base electrode with an in situ formed lithium ferrite scale that provides enhanced stability and catalytic activity in both high-temperature molten carbonate and chloride salts. The finding is stemmed from a discovery of the ionic potential-stability relationship and a basicity modulation principle of oxide films in molten salt. Using the iron-base electrode, we build a kiloampere-scale molten carbonate electrolyzer to efficiently convert CO2 to carbon and oxygen. More broadly, the design principles lay the foundations for exploring cheap, Earth-abundant, and long-lasting HT-OER electrodes for electrochemical devices with molten carbonate and chloride electrolytes.
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
Authors: Tomás-Daza Laureano , Rovirosa Llorenç , López-Martí Paula , Nieto-Aliseda Andrea , Serra François , Planas-Riverola Ainoa , Molina Oscar , McDonald Rebecca , Ghevaert Cedric , Cuatrecasas Esther , Costa Dolors , Camós Mireia , Bueno Clara , Menéndez Pablo , Valencia Alfonso , Javierre Biola M. 
Published: January 2023

AbstractLong-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. Here we introduce low input capture Hi-C (liCHi-C) as a cost-effective, flexible method to map and robustly compare promoter interactomes at high resolution. As proof of its broad applicability, we implement liCHi-C to study normal and malignant human hematopoietic hierarchy in clinical samples. We demonstrate that the dynamic promoter architecture identifies developmental trajectories and orchestrates transcriptional transitions during cell-state commitment. Moreover, liCHi-C enables the identification of disease-relevant cell types, genes and pathways potentially deregulated by non-coding alterations at distal regulatory elements. Finally, we show that liCHi-C can be harnessed to uncover genome-wide structural variants, resolve their breakpoints and infer their pathogenic effects. Collectively, our optimized liCHi-C method expands the study of 3D chromatin organization to unique, low-abundance cell populations, and offers an opportunity to uncover factors and regulatory networks involved in disease pathogenesis.
Enhancement of a prime editing system via optimal recruitment of the pioneer transcription factor P65
Authors: Chen Ronghao , Cao Yu , Liu Yajing , Zhao Dongdong , Li Ju , Cheng Zhihui , Bi Changhao , Zhang Xueli 
Published: January 2023

AbstractPrime editing is a versatile gene editing tool that enables precise sequence changes of all types in the genome, but its application is rather limited by the editing efficiency. Here, we first apply the Suntag system to recruit the transcription factor P65 and enhance the desired editing outcomes in the prime editing system. Next, MS2 hairpins are used to recruit MS2-fused P65 and confirmed that the recruitment of the P65 protein could effectively improve the prime editing efficiency in both the PE3 and PE5 systems. Moreover, this suggests the increased editing efficiency is most likely associated with the induction of chromatin accessibility change by P65. In conclusion, we apply different systems to recruit P65 and enhance the prime editing efficiency of various PE systems. Furthermore, our work provides a variety of methods to work as protein scaffolds for screening target factors and thus supports further optimization of prime editing systems.
Understanding the failure process of sulfide-based all-solid-state lithium batteries via operando nuclear magnetic resonance spectroscopy
Authors: Liang Ziteng , Xiang Yuxuan , Wang Kangjun , Zhu Jianping , Jin Yanting , Wang Hongchun , Zheng Bizhu , Chen Zirong , Tao Mingming , Liu Xiangsi , Wu Yuqi , Fu Riqiang , Wang Chunsheng , Winter Martin , Yang Yong 
Published: January 2023

AbstractThe performance of all-solid-state lithium metal batteries (SSLMBs) is affected by the presence of electrochemically inactive (i.e., electronically and/or ionically disconnected) lithium metal and solid electrolyte interphase (SEI), which are jointly termed inactive lithium. However, the differentiation and quantification of inactive lithium during cycling are challenging, and their lack limits the fundamental understanding of SSLMBs failure mechanisms. To shed some light on these crucial aspects, here, we propose operando nuclear magnetic resonance (NMR) spectroscopy measurements for real-time quantification and evolution-tracking of inactive lithium formed in SSLMBs. In particular, we examine four different sulfide-based solid electrolytes, namely, Li10GeP2S12, Li9.54Si1.74P1.44S11.7Cl0.3, Li6PS5Cl and Li7P3S11. We found that the chemistry of the solid electrolyte influences the activity of lithium. Furthermore, we demonstrate that electronically disconnected lithium metal is mainly found in the interior of solid electrolytes, and ionically disconnected lithium metal is found at the negative electrode surface. Moreover, by monitoring the Li NMR signal during cell calendar ageing, we prove the faster corrosion rate of mossy/dendritic lithium than flat/homogeneous lithium in SSLMBs.
Blue light-emitting diodes based on colloidal quantum dots with reduced surface-bulk coupling
Authors: Chen Xingtong , Lin Xiongfeng , Zhou Likuan , Sun Xiaojuan , Li Rui , Chen Mengyu , Yang Yixing , Hou Wenjun , Wu Longjia , Cao Weiran , Zhang Xin , Yan Xiaolin , Chen Song 
Published: January 2023

AbstractTo industrialize printed full-color displays based on quantum-dot light-emitting diodes, one must explore the degradation mechanism and improve the operational stability of blue electroluminescence. Here, we report that although state-of-the-art blue quantum dots, with monotonically-graded core/shell/shell structures, feature near-unity photoluminescence quantum efficiency and efficient charge injection, the significant surface-bulk coupling at the quantum-dot level, revealed by the abnormal dipolar excited state, magnifies the impact of surface localized charges and limits operational lifetimes. Inspired by this, we propose blue quantum dots with a large core and an intermediate shell featuring nonmonotonically-graded energy levels. This strategy significantly reduces surface-bulk coupling and tunes emission wavelength without compromising charge injection. Using these quantum dots, we fabricate bottom-emitting devices with emission colors varying from near-Rec.2020-standard blue to sky blue. At an initial luminance of 1000 cd m−2, these devices exhibit T95 operational lifetimes ranging from 75 to 227 h, significantly surpassing the existing records.
Cost-of-illness comparison between clinical judgment and molecular point-of-care testing for influenza-like illness patients in Germany
Authors: Brachmann M. , Serwa P. , Sauerland D. 
Published: January 2023

AbstractA high economic burden stems from seasonal influenza as a well-known but serious public health problem. Rapid diagnostic tests have not yet been integrated into routine use in German primary care, even though they are likely to reduce overall costs in cases of suspected infection. This study aims to demonstrate that the use of point-of-care testing (POCT) produces lower costs of illness compared to the costs incurred by relying on clinical judgment alone. With the help of a decision tree model, two different diagnostic approaches for influenza-like illness (ILI) in primary care were compared: (1) clinical judgment with no technical support and (2) POCT. The costs of illness, as well as their differences, vary widely among the three age groups considered (elderly people, adults, and children). For the pathway of using clinical judgment alone, the costs of illness sum up to 155.99 € for elderly people compared to 76.31 € for adults and 74.15 € for children. With POCT, the costs of illness for the elderly amount to 115,09 €, which is 26% lower than the costs without diagnostic support. The costs for adults and children are 74.42 € and 75.66 €, respectively, which means 2.5% lower costs of illness for adults and 2% higher costs for children. The results demonstrate that the use of POCT to support detecting influenza in ILI patients may reduce the overall cost of illness. The provided data can help governments make informed decisions about potential cost savings by integrating POCT into the reimbursement scheme.
The fecal and oropharyngeal eukaryotic viromes of healthy infants during the first year of life are personal
Authors: Rivera-Gutiérrez Xaira , Morán Patricia , Taboada Blanca , Serrano-Vázquez Angélica , Isa Pavel , Rojas-Velázquez Liliana , Pérez-Juárez Horacio , López Susana , Torres Javier , Ximénez Cecilia , Arias Carlos F. 
Published: January 2023

AbstractUsing a metagenomic sequencing approach, we described and compared the diversity and dynamics of the oropharyngeal and fecal eukaryotic virome of nine asymptomatic children in a semi-rural community setting located in the State of Morelos, Mexico. Ninety oropharyngeal swabs and 97 fecal samples were collected starting 2 weeks after birth and monthly thereafter until 12 months of age. In both niches, more than 95% of the total sequence reads were represented by viruses that replicate either in humans or in plants. Regarding human viruses, three families were most abundant and frequent in the oropharynx: Herpesviridae, Picornaviridae, and Reoviridae; in fecal samples, four virus families predominated: Caliciviridae, Picornaviridae, Reoviridae, and Anelloviridae. Both niches showed a high abundance of plant viruses of the family Virgaviridae. Differences in the frequency and abundance of sequence reads and diversity of virus species were observed in both niches and throughout the year of study, with some viruses already present in the first months of life. Our results suggest that the children’s virome is dynamic and likely shaped by the environment, feeding, and age. Moreover, composition analysis suggests that the virome composition is mostly individual. Whether this constant exposition to different viruses has a long-term impact on children’s health or development remains to be studied.