bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working in corona-designated departments in a fortified underground hospital: Concerns about corona and predictors of job burnout
Authors: Nashashibi Lauren , Khouri Marlyn , Meretyk Irit , Livni Tom , Cohen Noga , Fruchter Eyal 
Published: March 2023

BackgroundIn August 2020 during Israel’s second COVID-19 wave Rambam Medical Center opened the Sammy Ofer Fortified Underground Emergency Hospital. This was declared a regional Corona center in the north of Israel, receiving the most severe Corona patients from the region. Alongside the advanced inpatient capacity and technology within the underground facility, there was a severe shortage of trained medical and paramedical staff, as well as harsh working conditions. The current study examined the implications and effects of working in an underground facility on healthcare workers, focusing on emotion regulation tendencies and profession as predictors of job burnout.MethodsSeventy-six healthcare workers, who had worked in the underground hospital for a minimum continuous period of 2 weeks during the peak of the COVID-19 pandemic, and a control group of 40 healthcare workers from northern Israel were asked to fill out an online survey administered via Qualtrics (total sample 116). The survey comprised six questionnaires: a demographic survey questionnaire; a COVID-19 concerns questionnaire; a psychological distress questionnaire (DASS, Depression Anxiety Stress Scale); trait worry (PSWQ; Penn State Worry Questionnaire); emotion regulation (ERQ, Emotion Regulation Questionnaire), and burnout (SMBM, Shirom - Melamed Burnout Measure).ResultsIndependent-samples t-tests revealed no significant differences in psychological distress or burnout between Rambam Underground hospital workers and the control group. Conversely, COVID-19 concern scores were significantly different in the two groups, the Rambam hospital workers showing less concern (M = 2.9, SD = 0.73) than the control group (M = 3.47, SD = 0.76) [t(114) = −3.974, p &lt; 0.001]. Hierarchical linear regression analysis identified the significant predictors of burnout among healthcare workers. Participants’ profession (physician), psychological distress (total DASS score), and a personality trait of worry were statistically significant predictors for job burnout (p = 0.028, p &lt; 0.001, p = 0.023, respectively). Concerns about COVID-19 marginally predicted job burnout (p = 0.09). Group (underground vs. control) and emotion regulation tendencies did not predict burnout.ConclusionThe two groups showed no significant differences in psychological distress nor in burnout. Being a physician, having an intrinsic trait of being overly worried and experiencing psychological distress were significant predictors for job burnout among healthcare workers, regardless of work environment (underground vs. control).
Experiences of coercion amongst involuntary mental health care users in KwaZulu-Natal, South Africa
Authors: Shozi Zinhle , Saloojee Shamima , Mashaphu Sibongile 
Published: March 2023

BackgroundInvoluntary admission is a common practice globally. Previous international studies reported that patients experienced high levels of coercion, threats and a range of negative emotions. Little is known about the patients’ experience in South Africa. The aim of this study was to describe the patient’s experiences of involuntary admission at two psychiatric hospitals in KwaZulu-Natal.MethodsA cross-sectional descriptive quantitative study of patients admitted involuntarily was conducted. Demographic information was extracted from clinical records and interviews were conducted with consenting participants at discharge. The MacArthur Perceived Coercion Scale, the MacArthur Negative Pressures Scale, and the MacArthur Procedural Justice Scale, of the MacArthur Admission Experience Survey (short form) were utilized to describe participants’ experiences.ResultsThis study comprised 131 participants. The response rate was 95.6%. Most participants (n = 96; 73%) experienced high levels of coercion and threats (n = 110; 84%) on admission. About half (n = 61; 46.6%) reported that they felt unheard. Participants reported feeling sad (n = 68; 52%), angry (n = 54; 41.2%), and confused (n = 56; 42.7%). There was a significant association between good insight and a feeling of relief (p = 0.001), and between poor insight and feelings of anger (p = 0.041).ConclusionThe findings of this study confirm that most patients who were admitted involuntarily experienced high levels of coercion, threats, and exclusion from the decision-making process. Patient involvement and control of the decision-making process must be facilitated to improve clinical and overall health outcomes. The need for involuntary admission must justify the means.
Cost-effectiveness analysis of vaccination against COVID-19 in China
Authors: Zhou Huixuan , Ding Ningxin , Han Xueyan , Zhang Hanyue , Liu Zeting , Jia Xiao , Yu Jingjing , Zhang Wei 
Published: March 2023

IntroductionSince September 2020, Chinese populations aged &gt; 3 years have been encouraged to receive a two-dose inoculation with vaccines against coronavirus disease 2019 (COVID-19). This study aims to evaluate the cost-effectiveness of the current vaccination strategy amongst the general population in mainland China from a societal perspective.MethodsIn this study, we construct a decision tree with Markov models to compare the economic and health consequences of the current vaccination strategy versus a no-vaccination scenario, over a time horizon of one year and an annual discount rate of 5%. Transition probabilities, health utilities, healthcare costs, and productivity losses are estimated from literature. Outcome measures include infection rates, death rates, quality-adjusted life years (QALYs), and costs. The incremental cost-effectiveness ratio (ICER) is then calculated to evaluate the cost-effectiveness of the current vaccination strategy, and both one-way deterministic sensitivity analysis and probabilistic sensitivity analysis (PSA) are applied to assess the impact of uncertainties on results.ResultsOur simulation indicates that compared with a no-vaccination scenario, vaccination amongst the general population in mainland China would reduce the infection rate from 100% to 45.3% and decrease the death rate from 6.8% to 3.1%. Consequently, the strategy will lead to a saving of 37,664.77 CNY (US$5,256.70) and a gain of 0.50 QALYs per person per year on average (lifetime QALY and productivity loss due to immature death are included). The cost-saving for each QALY gain is 74,895.69 CNY (US$10,452.85). Result of the PSA indicates that vaccination is the dominating strategy with a probability of 97.9%, and the strategy is cost-effective with a probability of 98.5% when the willingness-to-pay (WTP) is 72,000 CNY (US$10,048.71) per QALY.ConclusionCompared with a no-vaccination scenario, vaccination among the general population in mainland China is the dominating strategy from a societal perspective. The conclusion is considered robust in the sensitivity analyses.
Impact of inactivated vaccines on decrease of viral RNA levels in individuals with the SARS-CoV-2 Omicron (BA.2) variant: A retrospective cohort study in Shanghai, China
Authors: Yang Peng , Dang Bianli , Kang Wen , Li Xiaofeng , Wang Tianping , Li Ruijuan , Peng Meijuan , Liu Yushen , Wang Linxu , Cheng Yan , Yu Suhuai , Wei Min , Gao Han , Kang Wenzhen , Shang Lei 
Published: March 2023

BackgroundSARS-CoV-2 Omicron (BA.2) has stronger infectivity and more vaccine breakthrough capability than previous variants. Few studies have examined the impact of inactivated vaccines on the decrease of viral RNA levels in individuals with the Omicron variant, based on individuals' continuous daily cycle threshold (Ct) values and associated medical information from the infection to hospital discharge on a large population.MethodsWe extracted 39,811 individuals from 174,371 Omicron-infected individuals according to data inclusion and exclusion criteria. We performed the survival data analysis and Generalized Estimating Equation to calculate the adjusted relative risk (aRR) to assess the effect of inactivated vaccines on the decrease of viral RNA levels.ResultsNegative conversion was achieved in 54.7 and 94.3% of all infected individuals after one and 2 weeks, respectively. aRRs were shown weak effects on turning negative associated with vaccinations in asymptomatic infections and a little effect in mild diseases. Vaccinations had a protective effect on persistent positivity over 2 and 3 weeks. aRRs, attributed to full and booster vaccinations, were both around 0.7 and had no statistical significance in asymptomatic infections, but were both around 0.6 with statistical significance in mild diseases, respectively. Trends of viral RNA levels among vaccination groups were not significant in asymptomatic infections, but were significant between unvaccinated group and three vaccination groups in mild diseases.ConclusionInactivated vaccines accelerate the decrease of viral RNA levels in asymptomatic and mild Omicron-infected individuals. Vaccinated individuals have lower viral RNA levels, faster negative conversion, and fewer persisting positive proportions than unvaccinated individuals. The effects are more evident and significant in mild diseases than in asymptomatic infections.
Changes in membrane fatty acids of a halo-psychrophile exposed to magnesium perchlorate and low temperatures: Implications for Mars habitability
Authors: García-Descalzo Laura , Lezcano María Ángeles , Carrizo Daniel , Fairén Alberto G. 
Published: March 2023

The presence of perchlorate salts in aqueous solutions bears two opposite effects on habitability. On the one hand, perchlorate salts trigger a decrease in the freezing point of the aqueous solutions, resulting in stable aqueous solutions at subzero temperatures, thereby widening the habitable conditions for potential microbial life. On the other hand, the presence of perchlorates in solution imposes a significant osmotic stress that compromises the integrity of microbial cell membranes, thereby restricting the habitable conditions in the same aqueous environment. Here we investigated the survivability and the changes in the composition of membrane fatty acids (FAs) of the bacterium Rhodococcus sp. JG-3 cells under warm (20°C), cold (4°C), and subzero temperatures (−10°C and −16°C), and in the presence (8 wt% and 16 wt%) and absence of magnesium perchlorate (Mg(ClO4)2). Bacterial cell survivability decreased with decreasing temperature and presence of magnesium perchlorate. However, Rhodococcus sp. JG-3 was able to tolerate up to 8 wt% Mg(ClO4)2 at −16°C. The presence of magnesium perchlorate in the medium decreased the concentration of total FAs, likely due to a destabilization of the molecules by the chaotropic effect of the perchlorate anion. At the maximum stress (both subzero temperatures and 16 wt% magnesium perchlorate), the composition of FAs changed, i.e., Rhodococcus sp. JG-3 cells increased the relative abundance of saturated FAs (SFAs) over the unsaturated (UFAs) or branched (BFAs). These changes in the proportion of FAs types may be a physiological response during cooling, aimed to improve lipid membrane stability. Interestingly, the composition and relative abundance of fatty acid types (i.e., SFAs, UFAs and BFAs) of Rhodococcus sp. JG-3 when simultaneously exposed to subzero temperatures and 16 wt% magnesium perchlorate was similar to that following freezing stress alone, suggesting that either both conditions triggered a similar response or that one response dominated over the other. Our findings contribute to understand the survivability and adaptation of extremophilic microorganisms under polyextreme conditions, such as those existing in the Martian subsurface today and/or in the past, which include the documented presence of magnesium perchlorate salts in ancient sediments and global cold temperatures.
Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model
Authors: González-Chávez Susana Aideé , López-Loeza Salma Marcela , Acosta-Jiménez Samara , Cuevas-Martínez Rubén , Pacheco-Silva César , Chaparro-Barrera Eduardo , Pacheco-Tena César 
Published: March 2023

Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applied at the disease’s preclinical phase on the joints of DBA/1 mice with collagen-induced arthritis (CIA). Twelve mice with CIA were randomly distributed into two groups: the CIA-Ex group, which undertook treadmill PE, and the CIA-NoEx, which was not exercised. The effects of PE were evaluated through clinical, histological, transcriptomics, and immunodetection analyses in the mice’s hind paws. The CIA-Ex group showed lower joint inflammation and damage and a decreased expression of RA-related genes (Tnf Il2, Il10, Il12a, IL23a, and Tgfb1) and signaling pathways (Cytokines, Chemokines, JAK-STAT, MAPK, NF-kappa B, TNF, and TGF-beta). TNF-α expression was decreased by PE in the inflamed joints. Low-intensity PE in pre-arthritic CIA reduced the severity through joint down-expression of proinflammatory genes and proteins. Knowledge on the underlying mechanisms of PE in preclinical arthritis and its impact on reducing the risk of developing RA is still needed.
Using TRIS-Buffered Plasma-Activated Water to Reduce Pathogenic Microorganisms on Poultry Carcasses with Evaluation of Physicochemical and Sensory Parameters
Authors: Große-Peclum Vanessa , Siekmann Lisa , Krischek Carsten , Avramidis Georg , Ochs Christian , Viöl Wolfgang , Plötz Madeleine 
Published: March 2023

Foodborne diseases are mainly caused by the contamination of meat or meat products with pathogenic microorganisms. In this study, we first investigated the in vitro application of TRIS-buffered plasma-activated water (Tb-PAW) on Campylobacter (C.) jejuni and Escherichia (E.) coli, with a reduction of approx. 4.20 ± 0.68 and 5.12 ± 0.46 log10 CFU/mL. Furthermore, chicken and duck thighs (inoculated with C. jejuni or E. coli) and breasts (with natural microflora) with skin were sprayed with Tb-PAW. Samples were packed under a modified atmosphere and stored at 4 °C for 0, 7, and 14 days. The Tb-PAW could reduce C. jejuni on days 7 and 14 (chicken) and E. coli on day 14 (duck) significantly. In chicken, there were no significant differences in sensory, pH-value, color, and antioxidant activity, but %OxyMb levels decreased, whereas %MetMb and %DeoMb increased. In duck, we observed slight differences in pH-value, color, and myoglobin redox forms for the Tb-PAW, which were not perceived by the sensory test persons. With only slight differences in product quality, its application as a spray treatment may be a useful method to reduce C. jejuni and E. coli on chicken and duck carcasses.
A Novel Design of Spike-Shaped Miniaturized 4 × 4 MIMO Antenna for Wireless UWB Network Applications Using Characteristic Mode Analysis
Authors: Suresh Ankireddy Chandra , Reddy Thatiparthi Sreenivasulu , Madhav Boddapati Taraka Phani , Alshathri Samah , El-Shafai Walid , Das Sudipta , Sorathiya Vishal 
Published: March 2023

In this article, a 4 × 4 miniaturized UWB-MIMO antenna with reduced isolation is designed and analyzed using a unique methodology known as characteristic mode analysis. To minimize the antenna’s physical size and to improve the isolation, an arrangement of four symmetrical radiating elements is positioned orthogonally. The antenna dimension is 40 mm × 40 mm (0.42λ0× 0.42λ0) (λ0 is the wavelength at first lower frequency), which is printed on FR-4 material with a width of 1.6 mm and εr = 4.3. A square-shaped defected ground framework was placed on the ground to improve the isolation. Etching square-shaped slots on the ground plane achieved the return losses S11 < −10 dB and isolation 26 dB in the entire operating band 3.2 GHz–12.44 GHz (UWB (3.1–10.6 GHz) and X-band (8 GHz–12 GHz) spectrum and achieved good isolation bandwidth of 118.15%. The outcomes of estimated and observed values are examined for MIMO inclusion factors such as DG, ECC, CCL, and MEG. The antenna’s performances, including radiation efficiency and gain, are remarkable for this antenna design. The designed antenna is successfully tested in a cutting-edge laboratory. The measured outcomes are quite similar to the modeled outcomes. This antenna is ideal for WLAN and Wi-Max applications.
Pirimicarb Induction of Behavioral Disorders and of Neurological and Reproductive Toxicities in Male Rats: Euphoric and Preventive Effects of Ephedra alata Monjauzeana
Authors: Khattabi Latifa , Chettoum Aziez , Hemida Houari , Boussebaa Walid , Atanassova Maria , Messaoudi Mohammed 
Published: March 2023

Carbamate pesticides are a risk to human well-being, and pirimicarb is the most widely employed carbamate insecticide. This ongoing investigation aimed to reveal its toxicity on neurobehavioral and reproductive function. The study was carried out on male Wistar rats by assessment of behavioral changes via experiments, such as the forced swim test and the elevated plus maze; determination of oxidative stress (checking parameters such as catalase activity, etc.); measurement of cortisol and testosterone serum titers, and IL-1β levels in the plasma and brain; and evaluation of histopathological lesions that induced pirimicarb after 28 days of gavage, specifically in the brain and testis. Traces of pirimicarb were analyzed in tissue extracts using LCMS/MS. At the same time, the beneficial and protective effect of EamCE (Ephedra alata monjauzeana Crude Extract) were tested. The outcomes showed considerable anxiety and depressive status, with an evident increase in cortisol and IL-1β titers and an important decrease in oxidative enzymes and testosterone. Significant histological lesions were also recorded. In addition, the LCMS/MS analysis affirmed the accumulation of pirimicarb in organ tissue from rats force-fed with pirimicarb. Conversely, EamCE demonstrated outstanding potential as a preventive treatment, restoring cognitive and physical performance, boosting fertility, enhancing antioxidant and anti-inflammatory activities and preserving tissue integrity. We concluded that pirimicarb has critical deleterious impacts on health, affecting the neuroimmune-endocrine axis, and EamCE has a general euphoric and preventive effect.
Circumstances Leading To Finding Out about Being Donor-Conceived and Its Perceived Impact on Family Relationships: A Survey of Adults Conceived via Anonymous Donor Insemination in Germany
Authors: Bauer Tobias , Meier-Credner Anne 
Published: March 2023

Recent empirical research on the psychosocial implications of donor insemination is increasingly based on data directly obtained from donor-conceived persons. This descriptive study on donor-conceived adults in Germany inquires into their experience of finding out about being donor-conceived and answers the following research question: how do German adults conceived via anonymous donor insemination find out about the means of their conception and how do they experience family relationships post finding out? An online self-administered questionnaire targeting German donor-conceived adults to obtain qualitative and quantitative data was administered between September and November 2020. Fifty-nine donor-conceived adults were recruited via the support and advocacy group Verein Spenderkinder. Participants had been born in heterosexual-couple-parented families, were between 21 and 46 years old, and found out about the circumstances of their conception between 5 and 46 years of age. A broad spectrum of contexts and circumstances in which participants learned about being donor-conceived were reported, such as discovery via medical records, through disclosure as a result of parental consideration of the child’s current life situation or through direct-to-consumer DNA testing. Finding out about the means of their conception was experienced by participants as affecting their relationships with their family members to different degrees and in various ways. This first systematic inquiry into German donor-conceived adults’ experiences expands the literature and provides basic data for further research. Direct-to-consumer DNA testing is identified as one emerging trigger for finding out, warranting future research. The heuristic value of further in-depth inquiry into donor-conceived adults’ relationship with family members other than their parents, in particular their siblings, is highlighted.
Transformation of last-mile delivery as a method of improving customer experience in the Russian Federation
Authors: Kurochkina A. A. , Shevchuk E. V. , Bikezina T. V. 
Published: March 2023

Aim. The presented study aims to analyze transformations that last-mile delivery has undergone during the years of the COVID-19 coronavirus pandemic in the Russian Federation, considering that, on the one hand, the final stage of delivery is considered the most problematic part of the delivery process, and on the other — the last mile is often a factor determining the customer’s choice and satisfaction when interacting with the company.Tasks. The authors identify problems that companies face due to changes in customer behavior and experience; search for possible solutions to these problems; analyze how satisfaction with the quality of last-mile delivery affects the customer’s decision to order goods from a particular supplier.Methods. This study uses the method of descriptive literature review, as well as methods of analysis, synthesis, comparison, and generalization.Results. Today, customer experience is as important an element of brand perception as product offering. Customers constantly seek more personalized, convenient, and secure ways to receive delivery services. Research shows that many buyers consider efficient and fast delivery a priority when making a purchase, not the price of goods. The increasing customer demand for quality of service and the boom in e-commerce have led to the development of new last-mile delivery methods that optimize the quality of customer service and contribute to building a strong relationship between the customer and the brand.Conclusions. Improving the quality of customer service through last-mile logistics can be a powerful tool in the competition, as delivery often turns out to be a key factor influencing the consumer’s purchase decision. The result of this study is the formation of an idea about the possible future development and prospects of last-mile delivery.