bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adrenal gland as first metastasis from broad ligament leiomyosarcoma: case report and literature review
Authors: Lan Yibi , Lv Zili , Wen Zhang , Guan Xuecun , Wu Bo , Fu Weijin 
Published: February 2023

Abstract
Background
Primary leiomyosarcoma(LMS) very rarely arises in the broad ligament. Metastasis is usually to lungs, liver, and so on, but seldomly to adrenal gland. Clinical presentation and imaging findings of metastatic broad ligament LMS are often nonspecific.The diagnosis is mainly based on histopathology and immunohistochemistry findings, and surgical resection is the preferred treatment method.
Case presentation
We present an extremely rare case of 49-year-old woman with recurrent broad ligament LMS metastasizing to right adrenal gland. Previously, she was diagnosed with broad ligament LMS and underwent laparoscopic hysterectomy plus bilateral salpingo-oophorectomy. The disease-free interval was 3 years until metastases were found. Computerized tomography (CT) performed, revealed right adrenal lesion. Adrenal lesion was completely resected. Pathological examination showed both the primary and the secondary LMS to have features of well-differentiated tumors.
Conclusions
Up to know, we highlight the uncommon case of broad ligament LMS with the adrenal metastatis. It is indicated that well-differentiated of broad ligament LMS also have the malignant potential of distant metastasis even if the patient have performed surgical treatment. We hope this uncommon case helps clinicians gain further understanding of metastasized broad ligament LMS.
Antimycobacterial Effects of Herbal Preparations Used In Buruli Ulcer Endemic Communities In Ghana
Authors: Ackah Ralphael Yaw , Amponsah Isaac Kingsley , Ekuadzi Edmund , Baah Michael Kwesi , Dickson Rita Akosua 
Published: February 2023

Abstract

Buruli ulcer is a devastating skin infection caused by Mycobacterium ulcerans. It is endemic in the Amansie West district of the Ashanti region of Ghana where patients rely mainly on herbal preparations from practitioners. This work aimed at validating some preparations employed by traditional healers in the Amansie West district for the management of Buruli ulcer. Four herbal preparations, obtained from practitioners in four communities were tested against the clinical M. ulcerans strain (NM203) using the resazurin microplate assay. Cytotoxicity test was done on the extracts using Chang liver cells. Chemical profiling of the active formulation was done using High-performance liquid chromatography. Some traditional herbal practitioners considered painless wounds in the extremities as diagnostic of BU whereas others relied on diagnosis of BU from a recognized conventional healthcare facility before proceeding to treat with herbal products. A formulation containing the roots of Cryptolepis sanguinolenta and seeds of Picralima nitida, as plant ingredients, was considerably active (MIC = 32µg/mL). The preparations were non-cytotoxic to Chang- liver cells. The herbal preparations showed considerable antimycobacterium ulcerans activity and are not toxic. A major peak in the HPLC chromatogram of the active formulation with a retention time of 17.86 min was identified as a marker for the quality analytics of the active formulation. A traditional herbal preparation used in Buruli ulcer endemic community was validated to show antimycobacterium ulcerans activity. Validation of similar preparations could afford novel drugs or products for this neglected tropical disease.
Polygenic Regulation by Flos Daturae in the Treatment of Breast Cancer:
A Study based on Network Pharmacology and Bioinformatics
Authors: Xiao Yang , Ma Mengcong , Li Yichen , Xiao Yunfeng 
Published: February 2023

Background:
In recent years, Chinese herbal medicine has been gradually emerging as a suitable
treatment option for breast cancer. However, the mechanism underlying its effects remains to be elucidated.

Objective:
The drug targets and Flos Daturae targets were intersected to obtain 86 component-disease
intersection genes.

Methods:
The String database and Cytoscape3.8.0 were employed, and finally, AKT1, MYC, EGFR,
MAPK14 PTGS2, and VEGFA were obtained as the six core genes.

Results:
According to the Gene Expression Profiling Interactive Analysis (GEPIA), six core gene correlation
analysis figures were constructed. The GO enrichment analysis and the KEGG pathway enrichment
analysis were conducted using the R package. Finally, molecular docking between the core genes and the
main active components was performed for verification.

Conclusion:
The results indicated that Flos Daturae has multiple components and multiple targets that
regulate the body functions, through which it plays a role in the treatment of breast cancer. In addition, it
was inferred that polygenic regulation is better than the single-gene approach in breast cancer treatment.
Estimation of Rotor Velocity and Stator Resistance for PMSM Drive using
Back-EMF SMO
Authors: Saadaoui Oussama , Khlaief Amor , Abassi Moez , Chaari Abdelkader 
Published: February 2023

Background:
Sensorless control of permanent magnet synchronous motor (PMSM) at
low speed remains a challenging task.

Introduction:
In this paper, a sensorless vector control of PMSM using a new structure of a back
EMF sliding mode observer (SMO) is proposed.

Methods:
To remove the mechanical sensors, a back EMF-SMO is built to estimate the rotor position
and speed of PMSM drives. The SMO, which replaces a sign function with a sigmoid function,
can reduce the chattering phenomenon. This sensorless speed control shows great sensitivity
to stator resistance and system noise.

Results & Discussion:
To improve the robustness of sensorless vector control, the back EMFSMO
technique has been used for stator resistance estimation. A novel stator resistance estimator
is incorporated into the sensorless drive to compensate for the effects of stator resistance variation.

Conclusion:
The validity of the proposed SMO with a 1.1 kw low-speed PMSM sensorless vector
control has been demonstrated by real experiments.
Study on Adsorption of Ag+ by Waste Tea: Adsorption Kinetics,
Thermodynamics, Isotherm Properties
Authors: Zhai Qing-Zhou , Li Xiao-Dong 
Published: February 2023

Aims:
In order to explore the adsorption effect of tea on heavy metal ions in industrial
wastewater, Ag+ is used as the research object in this paper.

Background:
In recent years, heavy metal pollution in water has seriously affected human
health and the stability of the ecological environment. In order to reduce the harmfulness of
heavy metals, various countries have issued a variety of control standards for heavy metals in
water, but there are still great restrictions in the prevention and control technology and level
of heavy metal pollution. Therefore, how to effectively treat heavy metal pollution in water
has become a hot topic in the field of water pollution management.

Objective:
The optimized conditions of the adsorption are obtained. Properties of the thermodynamics,
adsorption kinetics, and adsorption isotherm are obtained.

Methods:
In order to determine the best adsorption conditions for Ag+, the influence of factors
such as pH value, initial concentration of Ag+, tea dosage, contact time, and adsorption
temperature on the adsorption effect of tea is studied. The thermodynamics, adsorption kinetics,
and adsorption isotherm are studied.

Results:
The results showed that when the temperature is 25°C, the pH of the solution was
3.5, the amount of adsorbent was 2.5 g/L, the initial concentration of Ag+ was 125 μg/L and
the contact time was 30min, the adsorption rate was highest, reaching 98.11%. The thermodynamic
study of adsorption showed that at room temperature and above (298.15-318.15 K),
ΔG° < 0, indicating that the adsorption process can be spontaneous. The value of ΔGo in this
study is between -20 and -80 kJ/mol, indicating that this is a physicochemical adsorption process.
ΔHo = -80.111 kJ/mol < 0, indicating that the adsorption process of Ag+ is exothermic.
ΔSo = -188.977 J/(mol·K) < 0, indicating that the adsorption is a process of entropy reduction.
The adsorption kinetics study showed that the adsorption equilibrium capacity of different
concentrations had a large gap with the experimental results, and the correlation coefficient
was small by fitting the quasi-first-order kinetic equation and combining it with the experimental
measurements. When the quasi-second-order kinetic equation was used, the calculated
values of the equilibrium adsorption capacity of each concentration were basically close to the
experimentally measured values, and the correlation coefficient was large, so the kinetics of
the adsorption system of Ag+ by tea conformed to the quasi-second-order kinetic equation.
The adsorption isotherm of this adsorption process is accorded with the Freundlich model and
belonged to heterogeneous adsorption.

Conclusion:
Tea is a good adsorbent and has the potential for adsorption of Ag+.
Social Media Listening and Digital Profiling Study of People With Headache and Migraine: Retrospective Infodemiology Study
Authors: Goadsby Peter , Ruiz de la Torre Elena , Constantin Luminita , Amand Caroline 
Published: February 2023

Background
There is an unmet need for a better understanding and management of headache, particularly migraine, beyond specialist centers, which may be facilitated using digital technology.

Objective
The objective of this study was to identify where, when, and how people with headache and migraine describe their symptoms and the nonpharmaceutical and medicinal treatments used as indicated on social media.

Methods
Social media sources, including Twitter, web-based forums, blogs, YouTube, and review sites, were searched using a predefined search string related to headache and migraine. The real-time data from social media posts were collected retrospectively for a 1-year period from January 1, 2018, to December 31, 2018 (Japan), or a 2-year period from January 1, 2017, to December 31, 2018 (Germany and France). The data were analyzed after collection, using content analysis and audience profiling.

Results
A total of 3,509,828 social media posts related to headache and migraine were obtained from Japan in 1 year and 146,257 and 306,787 posts from Germany and France, respectively, in 2 years. Among social media sites, Twitter was the most used platform across these countries. Japanese sufferers used specific terminology, such as “tension headaches” or “cluster headaches” (36%), whereas French sufferers even mentioned specific migraine types, such as ocular (7%) and aura (2%). The most detailed posts on headache or migraine were from Germany. The French sufferers explicitly mentioned “headache or migraine attacks” in the “evening (41%) or morning (38%),” whereas Japanese mentioned “morning (48%) or night (27%)” and German sufferers mentioned “evening (22%) or night (41%).” The use of “generic terms” such as medicine, tablet, and pill were prevalent. The most discussed drugs were ibuprofen and naproxen combination (43%) in Japan; ibuprofen (29%) in Germany; and acetylsalicylic acid, paracetamol, and caffeine combination (75%) in France. The top 3 nonpharmaceutical treatments are hydration, caffeinated beverages, and relaxation methods. Of the sufferers, 44% were between 18 and 24 years of age.

Conclusions
In this digital era, social media listening studies present an opportunity to provide unguided, self-reported, sufferers’ perceptions in the real world. The generation of social media evidence requires appropriate methodology to translate data into scientific information and relevant medical insights. This social media listening study showed country-specific differences in headache and migraine symptoms experienced and in the times of the day and treatments used. Furthermore, this study highlighted the prevalence of social media usage by younger sufferers compared to that by older sufferers.
Inhibitory activity of Escherichia coli by type of teas and its liquors
Authors: Rohdiana Dadan , Arief Dede Zainal , Budiman Arista 
Published: February 2023

Study of analysis polyphenol content on tea, liquor, and its activity as antibacterial on Escherichia coli has been done conducted in Laboratory of Research, Department of Food Technology, Pasundan University, and Laboratory of Chemistry, Department of Chemistry, Faculty of Mathematic and Natural Science, Padjadjaran University. The result of this research showed that green tea sample has the highest polyphenol content, i.e. 23,18% followed orthodox and CTC (crushing tearing curling) black tea samples i.e. 14,23%Â and 13,93% respectively. Activity of inhibitory on E. coli showed that ratio tea and water 2 : 50 w/v has the best inhibition i.e. 117,71 mm2.
Дарьгангын лаавын тавцан дахь Шилийн Богд галт уулын геоморфологийн хэлбэр
Authors: Алтанболд Э. , Уламбадрах Х. , Бямбабаяр Г. , Санчир Д. 
Published: February 2023

The Cenozoic volcanism, which has been active in the territory of Mongolia since the beginning of the last century, has attracted the attention of Central Asian researchers. The purpose of this study is to analyze the geological research materials of the previous study and to determine the morphological origin and morphology of Shiliin Bogd volcano as the key representative of Cenozoic volcanism. In general, due to the lava flow of basic composition, several types of geomorphological forms have been identified, and the identification of the type of dominant distribution is associated with a relation with origin problem that has not been encountered in our country before, and because of the current importance, the selection of the Shiliin Bogd volcano in Dariganga Plateau becomes important. The morphometric analyses were performed in-field measurements and previous studies, also highlighted the faults in satellite and other images using the morpho-structure method in order to depict the geomorphology of the Shiliin Bogd volcano. By comparing the results of the morphometric analysis, the Shiliin Bogd volcano morphological type was determined and a schematic diagram of the volcano's origin was developed. A large lava flow of fundamental composition flowed along to the large faults that stretched from the northeast to the southwest of the Shiliin Bogd volcano, which resulted in the current morphological forms of Shiliin Bogd and other volcanoes. The lava flow had a flow rate of less than 50% SiO2, which led to the creation of a Lava Plato. The morphological formations of lava cones, which are semicircular and basal in composition, with the average slope of the Shiliin Bogd volcano crater in 410, depth 63 meters and crater average diameter 302 meters, have been compared with morphology of other volcanoes by morphometric analysis. Based on the researchers' research data, the age of the trap of Shiliin Bogd volcano can be traced to the late Quaternary age, possibly to the Holocene age. Further details of the age of the basalt rock need to be precise.
Тэрхийн Цагаан нуурын хотгорын морфодинамик хөгжил
Authors: Алтанболд Э. , Уламбадрах Х. , Гансүх Я. , Бямбабаяр Г. , Түвшин Г. , Юмчмаа Г. , Амаасүрэн Э. 
Published: February 2023

Data on the origin and morphology of lake depressions in Mongolia is poor and only 2 percent of total studies. The morphological patterns of the lake depressions caused by volcanic activity have not been well studied in Mongolia. The morphometric indicators of Khorgo volcanic lava plateau, its effect on the morphological changes of the lake depression, and the relationship between them are not studied in detail. The Khorgo volcanic lava is analyzed to clarify how it formed and compare it to the origin of the neighbouring Terkhiin Tsagaan Lake depression. This paper is defined the effect of Khorgo volcanic lava plateau on the origin of the Terkhiin Tsagaan Lake depression, based on morphometric analysis, remote sensing and geological mapping. Also study is checked by field measurements as identifying fault lengths, locations and morphology. Upon the Khorgo volcano activation, the valley of the Terkh River was dammed by a lava plateau. Lava damming formed the Terkhiin Tsagaan Lake depression, blocking the Terkh River valley. Another evidence is the age of the lava plateau and lake sediment. Terkhiin Tsagaan Lake area was three times larger than it is now (9000 years ago), comparing the terraces on the shoreline of the lake. The lake water outflows via the Suman River. The Suman River diversion has created a large canyon along fault. Changes in the water volume of Terkhiin Tsagaan Lake and the erosion of the Suman Gol canyon are inversely related. This study is concerned that the effect of the youngest volcano in Central Asia is achieved a role in the development of lake depression, and presents a basis for integrating morphometric analysis to define the main phases of volcanic activity and lake depression evolution. Current lake area and volume is under influences of climate and environmental changes and human activities.
Таац голын усны горимын судалгаа
Authors: Отгонсүрэн Ш. , Мөнхцэцэг З. , Ганболд Б. , Нарангэрэл Т. 
Published: February 2023

Surface water resources and flow regime of the river are dependent on climate, physical geography, soil condition, geology and hydrogeological conditions of the basin. These factors vary spatially and temporally and affect the runoff. To study the flow regime of the river including snowmelt and rainfall flow is crucial information for flood mitigation, control, water harvesting, hydro construction planning, dam and other hydrologic systems, etc. Therefore, we attempted to investigate the flow regime and its changes of the Taats river which is located in the Asian internal drainage basin in this study. The study was conducted using the daily runoff, precipitation and air temperature data for the period of 1975-2019. In addition, the Mann-Kendall test was applied to detect trend analysis for the annual runoff and maximum flow of the snowmelt and rainfall events. The probability of the maximum runoff of the snowmelt was estimated through the Gringorten method. The results show that the mean annual runoff and snowmelt flow decreased and rainfall flow has increased insignificantly in the study period. However, it was observed the changes in the timing of the snowmelt runoff shifted toward later in the year 1975-1990, earlier in the year 1991-2003 and on average in the period of 2004-2019. The maximum runoff of the snowmelt and rainfall is estimated at 13.2 m3/s and 275 м3/c, respectively in the 100 years.
Pengurangan Bullwhip Effect pada Rantai Pasok Air Minum Dalam Kemasan Menggunakan Metode Collaborative Planning, Forecasting, and Replenishment (CPFR): Studi Kasus
Authors: Qadafi Muhammad , Suhendar Endang , Prasasty Aliffia Teja 
Published: February 2023

CV Tirta Alam Dodu is a privately owned company engaged in the beverage industry in the form of AMDK. The problem faced by the company is that there is a difference between demand and sales, or better known as the bullwhip effect problem. The purpose of this study is to reduce the bullwhip effect on the supply chain and optimize the amount of product inventory according to the amount of demand. The method used is the Collaborative Planning, Forecasting, and Replenishment (CPFR) method. Based on the results of the research conducted, it can be concluded that the analysis of demand forecasting calculations on AMDK products at CV Tirta Alam Dodu was carried out using historical data on product demand through five analytical methods, including Linear Trend, Moving Average, Exponential Smoothing, Decomposition, and Winter's Model. The best forecasting resulted in Winter's Model which showed the smallest error value compared to the other four models. The way to minimize so that it does not become a bullwhip effect is to use the CPFR method, where the bullwhip effect value is obtained on glass mineral water products and gallons of mineral water of 0,985 and 0,898, respectively. This result shows that there is no amplification of demand and has reached the company's target, which is to fall below number one. The way to optimize inventory so that there is no excess stock or shortage of stock in the product is to make the amount of inventory based on the amount of demand from the forecasting results plus the safety stock.
Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar Capillary Dysplasia
Authors: H Steven Abman , Galambos Csaba , Logan J. Wells , Stankiewicz Pawel , Szafranski Przemyslaw , Zalles Carola , Gonzales Jose , Nath Sfurti , Patel Shalinkumar 
Published: February 2023

Severe BPD can be associated with clinical and histologic features that
are similar to ACD without evidence of FOXF1 genetic disease.
Importantly, lung FOXF1 and TMEM100 gene expression is markedly
decreased in severe BPD, suggesting that impaired FOXF1 signaling may
contribute to abnormal lung growth and refractory pulmonary hypertension
in BPD.
Etter liberalismen kommer nasjonalismen: 1880-årene viser vei
Authors: Hobson Rolf 
Published: February 2023

Sammendrag
Artikkelen reiser spørsmål om hvorvidt den gjengse sammenlikningen av dagens populisme med politiske tendenser i mellomkrigstiden er den mest relevante. En bedre analogi kan finnes mot slutten av 1800-tallet, da liberalismen ble utfordret av demokratiseringen og en forsterket nasjonalisme. Den liberale selvtilliten, siviliseringsmisjonen og den selvbekreftende fremskrittsfortellingen som dominerte i 1860- og 1870-årene, sammenliknes med tilsvarende tendenser i USA etter seieren under den kalde krigen. Etter finanskrakk (i 1873 og 2008), depresjon og lønnsnedslag uttrykte populistiske bevegelser misnøye med liberaliseringens konsekvenser. En utvidet stemmerett muliggjorde en mobilisering som brøt opp eksisterende partistrukturer og utfordret den liberale elitens dominans. Krav om proteksjonisme, innvandringsstopp og statlig inngripen i økonomien fikk gjennomslag under den økonomiske nedgangen som fulgte den store liberaliserings- og globaliseringsbølgen. Bitre sosiale konflikter begunstiget utbredelsen av konspirasjonsteorier. I møtet med denne utfordringen oppga borgerskapet mot slutten av 1800-tallet sin tidligere kosmopolitiske liberalisme og krevde en stadig mer pågående nasjonalistisk opprustnings- og ekspansjonspolitikk. Raseteoriene formet oppfatningen av både innen- og utenrikspolitikk. Dette opinionsskiftet destabiliserte det europeiske statssystemet. Artikkelen spør til slutt om det ikke er denne utviklingen – at det liberale borgerskapet sluttet å være liberalt – som er den viktigste lærdommen vi kan trekke av å sammenlikne vår tid med 1880-årene.
Abstract in English
After Liberalism Comes Nationalism, as in the 1880s: The article rejects the widespread parallels drawn between the rise of populism in the present day and the rise of authoritarianism and fascism in the interwar years. It seeks instead to find more relevant lessons in the rise of nationalism in the 1880s, when two decades of liberal deregulation and free trade were followed by the “long depression” between 1873 and 1896. Democratization made it possible for an expanded electorate to challenge the dominance of liberal elites. Many groups sought the protection of the nation state from international competition, in tariffs, the regulation of immigration, welfare provision and exclusive access to imperial markets. Conspiracy theories, more particularly modern economic antisemitism, identified the Jews as the “hidden force” behind the instability of globalization, whereas populist movements sought to expel immigrant labour that undercut wages. The most thorough political transformation occurred among the bourgeois elites, which by the end of the century rejected the liberal cosmopolitanism of the 1860s in favour of a neo-mercantilist linkage of military and economic strength, fuelling the colonial and arms races that destabilized international politics.