bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proportion of Births Protected Against Neonatal Tetanus and Its Associated Factors Among Mothers Who Gave Birth Within the Past 6 Months in Gozamn District, Northwest Ethiopia, 2022
Authors: Gashaw Anteneh , Tagele Anmut , Hunie Melaku , Amare Eyuel , Zewde Amare , Abebe Mesfine , Demeke Muluken , Kefelegn Samuel , Yehualashet Daniel , Alemu Asrat 
Published: February 2023

Abstract

Introduction:
An estimated 3.3 million newborn deaths occur each year around the world, with 9,000 babies dying every day in their first 28 days. Neonatal tetanus is tetanus that occurs within the first 28 days of life, and maternal immunization can reduce neonatal tetanus by 94%. However, not enough mothers were vaccinated to protect against neonatal tetanus globally, and only 49% of mothers in Ethiopia were protected. The proportion of mothers who were protected from neonatal tetanus was not determined yet in the study area. Because neonatal tetanus is such a serious disorder with such a high fatality rate and there is a need for more recent evidence on it, more research on birth protection against neonatal tetanus is needed.
Objective
To assess the proportion of births protected against neonatal tetanus and its associated factors among mothers who gave birth within the past 6 months in Gozamn district, Northwest Ethiopia, 2022.
Method
A community-based cross-sectional study was conducted in the Gozamn district, Northwest Ethiopia from April 1–30, 2022. A total sample size of 831 was used, and a two-stage stratified sampling technique was used. A structured and pre-tested questionnaire was used to collect the data, and the data was analysed by using StataV14. A logistic regression analysis was conducted, and the level of statistical significance was determined by a p-value of less than 0.05.
Result
The proportions of birth protected against neonatal tetanus were 58.57% in the study. Mother who had radio (AOR = 3.09,95%CI: 2.09, 4.56), mother who travel less than one hour to reach nearest health facility (AOR = 1.96,95%CI: 1.23,3.10), mother who gave birth of their last child in the health institution (AOR = 4.17,95%CI:2.39,7.28), mothers who had information from health professional (AOR = 2.56,95%CI:1.56,4.19) and > 4 ANC visit (AOR = 2.57,95%CI:1.55,4.26) were positive predictors of birth protected against neonatal tetanus.
Conclusion
In this study area, the proportion of mothers protected against neonatal tetanus was low. Professional based counselling related to TT vaccine, as well as interlinks and strength of different health care services such as ANC and delivery services are vital to increase proportion of birth protected against neonatal tetanus.
New Insights on the Adsorption of Phenol Red Dyes from Synthesized Wastewater using Activated Carbon Prepared from the Fe2(MoO4)3 -treated Mespilus Germanica Leaves: Equilibrium, Kinetic, and Thermodynamic Studies
Authors: Nobakht Alireza , Jafari Dariush , Esfandyari Morteza 
Published: February 2023

Abstract
Water shortage is considered as one of the main challenges of human life. A practical solution to this problem is the wastewater treatment. The removal of dyes from wastewaters has received considerable critical attention by researchers due to their high volume and toxicity. In the current research, the adsorption of phenol red dyes from synthetic wastewater using the activated carbon produced from Mespilus Germanica modified with Fe2(MoO4)3 was studied. The proposed adsorbent was characterized by FTIR, XRD, SEM, EDX/Map, BET, and Raman techniques. The optimal adsorption operating parameters were pH = 3, stirring rate of 500 rpm, 25°C, the dosage of adsorbent of 1 g/lit, dye initial concentration of 10 mg/lit, and contact time of 60 min. Furthermore, the successful regeneration of the adsorbent for 3 times denoted its capability in performing adsorption and desorption processes. Equilibrium studies showed that the adsorption of phenol red dyes by AC/Fe2(MoO4)3 was desirable and physical and the experimental data were fitted well by Freundlich model. In addition, the kinetic behavior of the current adsorption process was well described by the pseudo-second order kinetic model, while thermodynamic calculations showed that the process was exothermic and spontaneous.
Comparative whole-genome analysis of novel marine Vibrio campbellii from pure and non-axenic cultures reveals a unique plasmid
Authors: Orel Neža , Fadeev Eduard , Herndl Gerhard J. , Turk Valentina , Tinta Tinkara 
Published: February 2023

Abstract
Background
Vibrio spp. is ubiquitously present in the marine environment. Numerous Vibrio species are known pathogens affecting animal welfare and ecosystem function, causing significant economic losses. Hence, monitoring their presence accurate taxonomic identification and understanding their functional potential are important for disease control. All of this information is contained in the microorganism’s genome, which is easiest obtained from bacterial culture. Whole-genome sequencing in combination with new bioinformatics tools enables high phylogenetic resolution and provides insights into the full genetic potential of the microorganism, beyond traditional microbiological approaches.
Results
We assembled a complete genome of Vibrio campbellii isolated from the coastal Adriatic Sea. We showed that comparable genome sequences could be assembled from pure and non-axenic cultures (Average Nucleotide Identity value 99.98%) using a set of different bioinformatics tools, overcoming the problems of culture contamination frequently encountered in environmental microbiology. Based on the complete genome, we were able to accurately determine taxonomy, which often cannot be reliably determined with commonly applied genetic markers (e.g., 16S rRNA sequences). Pangenomic analyses with 10 reference genomes suggested that our newly assembled genome clusters in the sublineages of V. campbellii associated with diseases of marine organisms (e.g., Acute Hepatopancreatic Necrosis Disease in shrimps). Furthermore, our analysis revealed unique genomic features mainly associated with a new unique plasmid connected to bacterial defense (e.g., type I restriction-modification systems, CRISPR Csa3 proteins) and with the propagation of genetic material (e.g., transposases associated with horizontal gene transfer, ardC genes increasing plasmids host range).
Conclusions
Our completed genome assembly from a non-axenic culture highlights the possibility of obtaining complete genomic information when encountering contamination events, or beyond our study, even in the case of co-cultures. With this new complete V. campbellii genome we are contributing novel insights into the genomic characteristics and functional potential of this potential pathogen. In the light of projected human pressures on coastal regions and associated marine ecosystem services, pathogen surveillance and control of possible disease outbreaks are crucial. Our study reveals a novel, unique mobile element associated with V. campbellii that could potentially ease the propagation of its associated genetic material across different microbes.
Immunotherapy Responsiveness and Risk of Relapse in Down Syndrome Regression Disorder
Authors: Santoro Jonathan , Spinazzi Noemi , Filipink Robyn , Hayati-Rezvan Panteha , Kammeyer Ryan , Patel Lina , Sannar Elise , Dwyer Luke , Banerjee Abhik , Khoshnood Mellad , Jafarpour Sabaj , Boyd Natalie , Partridge Rebecca , Gombolay Grace , Christy Alison , de Asua Diego Real , Ortega Maria del Carmen , Manning Melanie , Mater Heather Van , Worley Gordon , Franklin Cathy , Stanley Maria , Brown Ruth , Capone George , Quinn Elieen , Rafii Michael 
Published: February 2023

Abstract

Down syndrome regression disorder (DSRD) is a clinical symptom cluster consisting of neuropsychiatric regression without an identifiable cause. This study evaluated the clinical effectiveness of IVIg and evaluated clinical characteristics associated with relapse after therapy discontinuation. A prospective, multi-center, non-randomized, observational study was performed. Patients met criteria for DSRD and were treated with IVIg. All patients underwent a standardized wean off therapy after 9–12 months of treatment. Baseline, on therapy, and relapse scores of the Neuropsychiatric Inventory Total Score (NPITS), Clinical Global Impression-Severity (CGI-S), and the Bush-Francis Catatonia Rating Scale (BFCRS) were used to track clinical symptoms. Eighty-two individuals were enrolled in this study. Patients had lower BFCRS (MD: -6.68; 95% CI: -8.23, -5.14), CGI-S (MD: -1.27; 95% CI: -1.73, -0.81), and NPITS scores (MD: -6.50; 95% CI: -7.53, -5.47) while they were on therapy compared to baseline. Approximately 46% of the patients (n = 38) experienced neurologic relapse with wean of IVIg. Patients with neurologic relapse were more likely to have any abnormal neurodiagnostic study (χ2 = 11.82, p = 0.001), abnormal MRI (χ2 = 7.78, p = 0.005), and abnormal LP (χ2 = 5.45, p = 0.02), and a personal history of autoimmunity (OR: 6.11, p < 0.001) compared to patients without relapse. IVIg was highly effective in the treatment of DSRD. Individuals with a history of personal autoimmunity or neurodiagnostic abnormalities were more likely to relapse following weaning of immunotherapy, indicating the potential for, a chronic autoimmune etiology in some cases of DSRD.
Premenopausal women with breast cancer in the early postpartum period show molecular profiles of invasion and are associated with poor prognosis
Authors: Prabhu Jyothi , Nimbalkar Vidya , P Snijesh V , Rajarajan Savitha , Alexander Annie , Kaluve Rohini , Ramesh Rakesh , BS Srinath 
Published: February 2023

Abstract

Background Though pregnancy and lactation are considered as protective factors against development of breast cancer (BC), small proportion of young premenopausal women develop tumors within 5 to 10 years of last childbirth presenting with aggressive disease. The exact mechanisms that lead to poor prognosis in these postpartum breast cancers (PPBC) is largely unknown. Methods We have evaluated the association of clinical and reproductive factors with BC in a cohort of women ≤ 45 years (N = 155) with long term follow up. Based on duration since last childbirth (LCB), they were grouped into PPBC1 (LCB ≤ 5 years), PPBC2 (LCB between 6–10 years), PPBC3 (LCB > 10 years) and NPBC (age matched nulliparous BC patients). Disease free survival and hazard associated with recurrence/metastasis were compared between the groups. RNA sequencing of tumor samples from three different parous groups (n = 10) was performed and transcriptomic data was analyzed for differentially expressed genes and altered pathways. Results Women in the PPBC1 group had an early menarche and late first and last childbirth compared to other groups. Survival analysis within lymph node positive tumors showed that PPBC1 tumors had a worse prognosis compared to PPBC2 and NPBC tumors (p = 0.015, and p = 0.026 respectively with a higher hazard both by univariate and multivariate analysis). Clustering of the differentially expressed genes between the groups showed distinct expression in early PPBC (PPBC1) tumors. Pathway analysis revealed upregulation of invasive signature along with T cell exhaustion, extracellular matrix remodeling, angiogenesis and epithelial to mesenchymal transition within early PPBC tumors. Conclusion PPBC diagnosis may represent a unique subtype of cancer that requires distinct clinical and translational research to understand altered pathways. Clinical parameters and biologic subtyping alone may be insufficient to accurately project the risk of recurrence and optimal treatment strategies in young patients who develop BC in the early postpartum period.
Risk factors associated with free microvascular flaps using a vascular stapler: A retrospective study
Authors: Guo Runying , Lin Sen , Guo Runzhi , Liu Sirui , Wang Meiyue , Li Rui 
Published: February 2023

Abstract
Objective: To analyze the risk of perioperative complications associated with preoperative risk factors in patients who underwent anastomosis of free head and neck flaps using a vascular stapler.
Methods: We reviewed the data of all patients who underwent anastomosis of free head and neck flaps using a vascular stapler in our hospital between 2019 and 2020 (n=171). They were grouped according to age, weight, smoking, alcohol consumption, diabetes, and high blood pressure. Logistic regression analysis was used to evaluate the relationship between these factors and flap necrosis.
Results: Among the 171 patients who underwent single vein anastomotic reconstruction of free head and neck flaps with a vascular stapler, five exhibited flap necrosis. Age,smoking,alcohol consumption, diabetes, and hypertension were found to affect the prognosis of surgery; among these, diabetes was a risk factor for flap necrosis.
Conclusion: Attention should be paid to the control of blood glucose in patients undergoing free vascularized flaps using a stapler.
Effect of sarcopenia and albumin-bilirubin grade on survival in patients with hepatocellular carcinoma under transarterial chemoembolization
Authors: Wang Xiaojuan , Li Jinlong , Wang Jitao , Wang Wenchuan , Jia Linyi , Cui Fusheng , Gao Fengxiao 
Published: February 2023

Abstract
Aim: It is unclear that the prognostic value of sarcopenia and albumin-bilirubin (ALBI) grade on patients with hepatocellular carcinoma (HCC) under transarterial chemoembolization（TACE）.The purpose of this study was to explore the effect of sarcopenia and ALBI grade on the survival time of patients after TACE for HCC.
Method: 110 HCC patients receiving TACE were enrolled in this retrospective study from 2015 to 2019. Psoas muscle index (PMI) was calculated as the left-right area of the psoas muscle at the third lumbar vertebra, divided by height squared.Patients were classified into two groups (non-sarcopenia and sarcopenia) depending on an index < 6.36 and < 3.92 cm2 /m2 for men and women, respectively. According to the formula ALBI =（log10 bilirubin*0.66）+（albumin*-0.085），the patients were classified into 3 grade.We assessed whether PMI and ALBI grade have effect on overall survival (OS) .
Results: Of the patients enrolled in the study,80(72.7%) were sarcopenia,30(27.3%) were non-sarcopenia,and 32(29.09%),74(67.3%),4(3.6%) patients were be classified into ALBI 1,2,3 respectively. There were no significant differences in the number of deaths between non-sarcopenia and sarcopenia(non-sarcopenia 63.8%, sarcopenia 56.7%,p=0.496),but according to ALBI grouping, the number of deaths was significant(ALBI grade 1 46.9%,ALBI grade 2 and 3,67.9%,p=0.039).In univariate analyses,ALBI grade[ALBI 2, hazard ratio(HR)=2.323;95%CI,1.291-4.182,P=0.005; ALBI 3,HR=21.915;95%CI,6.441-74.569,P=0.000],Barcelona Clinic Liver Cancer staging system (BCLC stage)(BCLC B,HR=2.706;95%CI,1.147-6.388,P=0.023; BCLC C,HR=5.007;95%CI,2.024-12.386,P=0.000),number of tumours (>3) (HR=1.71;95%CI,1.061-2.757,P=0.028),maximum tumour diameter (>3 cm) (HR=3.042;95%CI,1.627-5.687,P=0.000) and metastasis(HR=2.056;95%CI, 1.062-3.981,P=0.033) were associated with poor OS,but sarcopenia had no effect on OS(HR=1.15;95%CI,0.664-1.993,P=0.618).Multivariate analysis showed that ALBI grade(ALBI 2, HR=1.941;95%CI,1.016-3.705,P=0.044;ALBI3,HR=10.688; 95%CI,2.51-45.502,P=0.001), metastasis(HR=2.925;95%CI, 1.257-6.808,P=0.013), maximum tumour diamete(>3 cm)(HR=2.335;95%CI, 1.341-4.068,P=0.003) could significantly stratify the patients with different OS.
Conclusion: ALBI grade is an important predictor of poor prognosis in HCC patients under TACE,but PMI doesn't contribute to prognostic stratification. These results suggest ALBI grade as another liver function grading system are independent predictors of OS,it is regrettable that PMI that reflects the nutritional status of the body could not provide clinical prognosis value.
High-Resolution Bio-potential and Bio-impedance Investigation of the Face
Authors: Levit Bara , Hanein Yael 
Published: February 2023

Abstract
The importance of facial muscles is evident in the critical role they play in numerous functions. The purpose of some actions (e.g. chewing, swallowing) is clear. Others, such as yawning and the expression of emotion are more elusive. Despite their ubiquity, the manner by which facial muscles affect physiological processes is not clear. In particular, how facial muscles affect blood flow has received little attention. Here we present a new wearable approach to investigate the face. Soft electrode arrays were used to detect subtle changes in blood flow in the temporal superficial artery following muscle activity. Changes in response to muscle activation are clearly evident and conspicuously more complex than in the forearm. Simultaneous bio-potential and bio-impedance mapping of the face unravels the complex manner by which these muscles help shape human physiology.
Metabolic parameters differentially influence varying sonographic risk-stratified thyroid nodules: independent of H. pylori infection
Authors: Yan Xiaoli , Bi Xiaoting , Qin Xia , Wang Dan , Zhang Yuan 
Published: February 2023

Abstract
Purpose
The relationship between the risk of benign or malignant thyroid nodule and Helicobacter pylori Infection are controversial. This study also evaluates the relationship between metabolic parameters and varying sonographic risk-stratified thyroid nodules in a Chinese population.
Methods
The examinations included interview, ultrasonography of the thyroid, carbon-13 (C13) urea breath test, and serum assays of biochemical measurements.
Results
A total of 19246 adults who underwent thyroid ultrasonography were recruited in this study in Chongqing, China, from January, 2017 to March, 2022. The present study showed that, after adjustment for potential risk factors, both benign group and suspicious malignant group were positively associated with age, BMI and SBP. Different from suspicious malignant group, higher Glu (OR = 1.040, 95%CI: 1.01 ~ 1.08) level was independent factors affecting benign TN occurrence, while DBP (OR = 0.993, 95%CI = 0.991 ~ 0.994) and TC (OR = 0.992, 95%CI = 0.88 ~ 0.97) were negatively corrected. Meanwhile, HDL (OR = 0.899, 95%CI = 0.83 ~ 0.98) was independently and negatively related to suspicious malignant TN formation.
Conclusions
The present study showed that, metabolic parameters, such as age, gender, SBP, DBP, BMI, Glu, TC, TG and HDL levels, differentially influenced varying severity TN by ultrasonography. H.pylori infection is not an independent risk factors for either benign or suspicious TN occurrence. Contrary to previous understanding, our result suggests that older men have a higher risk of suspicious malignant thyroid nodules than aged women.
The role of pelvic floor electrophysiological parameters in the prediction of urinary incontinence for women in early postpartum period: a retrospective study
Authors: Fang Jianqi , Lin Shuqin , Chen Yi , He Sha , Wu Yanfang , He Xiaojun , Wu Ting , Zhang Ronghua , Lin Juan , lin Lihua 
Published: February 2023

Abstract
Objectives
To evaluate the role of pelvic floor electrophysiological parameters in the prediction of urinary incontinence for women in early postpartum period using pelvic floor surface electromyography.
Methods
This retrospective study included 19462 participants who visited Fujian Maternity and Child Health Hospital from March 2020 to February 2022. All participants were assessed by medical professionals for general information and pelvic floor surface electromyography.
Results
Multivariate logistic regression showed that age, body mass index, parity, vaginal delivery, forceps delivery, and prenatal urinary incontinence had a negative impact on postpartum urinary incontinence (OR 1.027, 95% CI: 1.014–1.040, P < 0.001, OR 1.079, 95% CI: 1.062–1.096, P < 0.001, OR 1.206, 95% CI: 1.090–1.335, P < 0.001, OR 4.756, 95% CI: 4.136–5.469, P < 0.001, OR 6.056, 95% CI: 4.629–7.921, P < 0.001, and OR 3.219, 95% CI: 2.918–3.551, P < 0.001, respectively)
Conclusions
We didn’t find any relationship between the parameters of pelvic floor surface electromyography and urinary incontinence, but there was a negative impact of age, body mass index, parity, vaginal delivery, forceps delivery, and prenatal urinary incontinence on postpartum urinary incontinence.
Geochemical characterization and WQI based assessment of groundwater health risk using GIS in tropical river basin: Case study in Kirama-ara River basin, Southern Province, Sri Lanka.
Authors: Dissanayake Indunil Pradeep , Perera T.A.N.T , Jayasinghe G.Y 
Published: February 2023

Abstract
In the Kirama-ara River basin, Matara, southern region of Sri Lanka, a variety of agricultural inputs are utilized, and flooding is a common hazard. As a result, the complete physicochemical profile of the groundwater in the Kirama-ara river basin is yet undiscovered. Therefore, the goals of this study were to (a) identify the geochemical characteristics and changes in water quality, (b) evaluate non-carcinogenic health risk and develop a GWQI, and (c) generate a spatial distribution map for groundwater physicochemical parameters in the Kirama-ara river basin in Matara, Sri Lanka. The physiochemical characteristics of 16 groundwater samples, including pH, electrical conductivity (EC), total dissolved solids (TDS), Na+, K+, Ca2+, Mg2+, Cl−, NO3−, PO43−, and SO42−, were examined for spatial and temporal variations. The pH, NO3−, and PO43− values of 50%, 6.25%, and 12.5% of the samples, respectively, were determined to be beyond the allowable limit by both the WHO and SLS. The physicochemical investigation demonstrates that while 87.5% of the locations were acceptable for drinking, 12.5% of them lacked sufficient amounts. The most common hydro-chemical facies were Ca2+-Mg2+-HCO3−, mixed Ca2+-Mg2+-Cl− face, and Ca2+-Cl−. Rock weathering has a profound impact on the ionic composition and chemistry of groundwater. Additionally, health risk assessment research conducted in accordance with United States Environmental Protection Agency rules revealed that children face greater health risks than adults. To build reasonable management plans for long-term groundwater quality conservation and public health, more research is required.
The salvage therapy utilizing human umbilical cord-derived mesenchymal stem cells to treat severe COVID-19 patients: case series
Authors: Yao Weiqi , Jiang Yingan , Yuan Qiaoyu , Wu Wenjie , Hou Ruizhen , Qi Qi , Dong Haibo , Zhang Yun , Zhang Yu 
Published: February 2023

Abstract
Background: COVID-19 has become one of the biggest challenges globally, yet no specifically effective medication has been developed. Mesenchymal stem cells (MSCs) exhibit properties of immune regulation and regeneration, which may suppress the over-inflammatory response and promote recovery of lung damage caused by COVID-19 and offer the potential as a therapeutic option.
Methods: At the very beginning of COVID-19 epidemic in 2020, we investigated the use of human umbilical cord-derived MSCs (hUC-MSCs) as a salvage therapy in five severe COVID-19 patients, with each patient receiving intravenous infusion of hUC-MSCs three times.
Results: All patients showed significant improvement in clinical manifestations, including laboratory biomarkers and findings of lung computed tomography images, after at least one dose of MSC therapy.
Conclusion: These results suggest that MSC therapy is safe and can reduce the inflammatory response and alleviate the clinical symptoms of critically ill COVID-19 patients.