bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for distant metastasis and prognosis in stage T1 esophageal cancer: A population-based study
Authors: Zhu Kai , Jia Mingyue , Ji Linlin , Wang Guangshun 
Published: January 2023

PurposeStage T1 esophageal cancer (EC) with distant metastasis (DM) is rare and poorly understood. In this study, we aimed to construct and validate a novel nomogram for predicting the probability of DM in T1 EC patients.MethodsA total of 1,663 eligible T1 EC patients were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2015. The patients were randomly divided into training and validation cohorts. Univariate and multivariate logistic analyses in the training cohort were used to identify risk factors related to DM, and then these risk factors were applied to construct the nomogram. Receiver operating characteristic (ROC) curves, the area under the curve (AUC), calibration plots, the Hosmer-Lemeshow (HL) test, and decision curve analysis (DCA) were used to evaluate the nomogram.ResultsAmong the 1,663 patients identified, 143 (8.6%) had DM. Five risk factors (tumor location, lymph node status, tumor length, T1 subtype, and grade) were significant predictors of DM. The AUC values were 0.828 and 0.851 in the training cohort and validation cohort, respectively, revealing good discrimination. The calibration plots in the training cohort and validation cohort both showed good consistency. DCA showed that the nomogram was clinically effective. In addition, the nomogram has a good risk stratification ability to identify patients with different risks according to the nomogram score. In terms of survival analysis, univariate and multivariate Cox analyses showed that age, race, tumor length, grade, lymph node status, M stage and treatment were significant prognostic factors for overall survival (OS). For cancer-specific survival (CSS), the independent prognostic factors were age, tumor length, histology, grade, lymph node status, M stage and treatment.ConclusionThe nomogram could effectively predict the probability of DM in T1 EC patients. It can aid clinicians in detecting high-risk patients and making individual clinical decisions.
Tourniquet application in primary total knee arthroplasty for osteoarthritis: A systematic review and meta-analysis of randomized controlled trials
Authors: Han Jinchang , Zhang Xiao-yu , Mu Shi-yin , Liu Shi-long , Cui Qing-tong , Zhang Chao , Liu Ai-feng 
Published: January 2023

ObjectiveThe aim of this study was to identify the influence of a tourniquet on the blood loss, transfusion requirement, swelling, pain, knee function, range of motion (ROM), operation time, bone cement mantle thickness, and complications in patients operated with total knee arthroplasty (TKA).MethodsTwo authors independently retrieved PubMed, Embase, and CENTRAL to identify eligible randomized controlled trials (RCTs) evaluating the effectiveness of a tourniquet in TKA. Fixed- (I2 &lt; 50%) or random-effects (I2 &gt; 50%) models were selected to perform meta-analysis according to the value of I2. Mean difference (MD) and risk ratio were selected as the effect sizes for continuous and dichotomous variables, respectively.ResultsA total of 29 RCTs, involving 2,512 operations (1,258 procedures with a tourniquet and 1,254 procedures without a tourniquet), were included, and 18 outcomes were compared. Tourniquet application could significantly decrease intraoperative blood loss (MD = −138.72 ml, p &lt; 0.001), shorten operation duration (MD = −1.77 min, p &lt; 0.001), and increase cement mantle thickness (MD = 0.17 mm, p &lt; 0.001). However, it was significantly associated with increased postoperative pain intensity, decreased full ROM/flexion ROM/extension ROM, poorer knee function, increased knee swelling, and increased length of hospital stay (LOS) at several follow-up points (p &lt; 0.050). No significant difference was found for postoperative draining volume, total blood loss, transfusion rate, change of Hb level, and risks of deep venous thrombosis and all complications.ConclusionsTourniquet application could only decrease the intraoperative blood loss but has no effectiveness on the total blood loss and transfusion requirement. On the contrary, it has a reverse effect on the pain score, knee function, ROM, swelling, and LOS.
ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases
Authors: Barboza Bruno Rafael , Thomaz Sandra Maria de Oliveira , Junior Airton de Carvalho , Espreafico Enilza Maria , Miyamoto Jackson Gabriel , Tashima Alexandre Keiji , Camacho Maurício Frota , Zelanis André , Roque-Barreira Maria Cristina , da Silva Thiago Aparecido 
Published: January 2023

Receptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific manner. ArtinM, a D-mannose-binding lectin obtained from Artocarpus heterophyllus, has affinity for the N-glycans core. Immunomodulation by ArtinM toward the Th1 phenotype occurs via its interaction with TLR2/CD14 N-glycans on antigen-presenting cells, as well as recognition of CD3γ N-glycans on murine CD4+ and CD8+ T cells. ArtinM exerts a cytotoxic effect on Jurkat human leukemic T-cell line and human myeloid leukemia cell line (NB4). The current study evaluated the effects of ArtinM on murine and human B cells derived from non-Hodgkin’s lymphoma. We found that murine B cells are recognized by ArtinM via the CRD, and the ArtinM stimulus did not augment the proliferation rate or production of IL-2. However, murine B cell incubation with ArtinM augmented the rate of apoptosis, and this cytotoxic effect of ArtinM was also seen in human B cell-lines sourced from non-Hodgkin’s lymphoma Raji cell line. This cytotoxic effect was inhibited by the phosphatase activity of CD45 on Lck, and the protein kinases of the Src family contribute to cell death triggered by ArtinM.
Manganese Luminescent Centers of Different Valence in Yttrium Aluminum Borate Crystals
Authors: Molchanova Anastasiia , Boldyrev Kirill , Kuzmin Nikolai , Veligzhanin Alexey , Khaydukov Kirill , Khaydukov Evgeniy , Kondratev Oleg , Gudim Irina , Mikliaeva Elizaveta , Popova Marina 
Published: January 2023

We present an extensive study of the luminescence characteristics of Mn impurity ions in a YAl3(BO3)4:Mn crystal, in combination with X-ray fluorescence analysis and determination of the valence state of Mn by XANES (X-ray absorption near-edge structure) spectroscopy. The valences of manganese Mn2+(d5) and Mn3+(d4) were determined by the XANES and high-resolution optical spectroscopy methods shown to be complementary. We observe the R1 and R2 luminescence and absorption lines characteristic of the 2E ↔ 4A2 transitions in d3 ions (such as Mn4+ and Cr3+) and show that they arise due to uncontrolled admixture of Cr3+ ions. A broad luminescent band in the green part of the spectrum is attributed to transitions in Mn2+. Narrow zero-phonon infrared luminescence lines near 1060 nm (9400 cm−1) and 760 nm (13,160 cm−1) are associated with spin-forbidden transitions in Mn3+: 1T2 → 3T1 (between excited triplets) and 1T2 → 5E (to the ground state). Spin-allowed 5T2 → 5E Mn3+ transitions show up as a broad band in the orange region of the spectrum. Using the data of optical spectroscopy and Tanabe–Sugano diagrams we estimated the crystal-field parameter Dq and Racah parameter B for Mn3+ in YAB:Mn as Dq = 1785 cm−1 and B = 800 cm−1. Our work can serve as a basis for further study of YAB:Mn for the purposes of luminescent thermometry, as well as other applications.
Transformaciones en el desarrollo urbano de Manta, Ecuador: desde la ciudad colonial hasta la ciudad fragmentada
Authors: Samada Grasst Yanet 
Published: January 2023

La expresión territorial y transformaciones en el desarrollo urbano de la ciudad de Manta en el Ecuador es una característica de la ciudad intermedia, que muestra un gran crecimiento demográfico, unido a un extraordinario consumo de suelo para usos urbanos, determinado por la vocación de puerto y ubicación estratégica. La presente investigación se direccionó en analizar las transformaciones en el desarrollo urbano de Manta, desde la ciudad colonial hasta la fragmentada. Para ello, fue necesario la aplicación de una metodología descriptiva, bajo un enfoque cualitativo a través del análisis documental en donde se identificó, revisó y clasificó de forma rigurosa la literatura especializada que permitió deducir el paso del modelo compacto y urbano polinuclear, propio de las fases iniciales de la investigación, al disperso fragmentado y sectorial; sustentado en los ejes viales principales que son utilizados de manera poco homogénea en zonas periféricas, sin una adecuada planificación de las áreas de expansión que ha inducido a un crecimiento urbano fragmentado. Entre los principales hallazgos se identificó como la dinámica económica vinculada a las actividades portuarias, fabriles y pesca de exportación, supusieron la mayor expansión de la superficie urbana consolidando un patrón de baja densidad apoyado en los nuevos ejes viarios. El resultado es una ocupación dispersa, desordenada, claramente segregada y donde las escasas políticas urbanas han alentado la inversión inmobiliaria en las zonas mejor dotadas de equipamientos, servicios y conectividad.
Ações de enfermagem ao portador de Esquizofrenia: Evidências científicas atuais
Authors: de Barros Cícera Cristiane , Marinho Júnior Ivan Nunes Marinho , Soares Jandson de Oliveira , Pontes Alessandra Nascimento 
Published: January 2023

Introdução: As intervenções de enfermagem discutidas na literatura são: realizar avaliações biopsicossociais levando em consideração as características culturais do paciente; Criação e implementação de planos para melhorar as condições de saúde do paciente e sua família; informar o paciente e sua família sobre as características da doença. O mais importante é evitar se envolver diretamente com o conteúdo psicótico na frente de uma pessoa com sintomas psicóticos. Isso significa que é melhor mostrar vontade de ajudar o paciente na situação que está causando sofrimento do que argumentar que nada do que ele está imaginando é real. Objetivo geral: é entender quais são as ações que a equipe de enfermagem deve prestar aos portadores dessa doença. Metodologia: trata-se de uma revisão de bibliografias, de forma qualitativa. Resultados: Considerações finais: Diante dessa perspectiva, fica claro o quão importante é o estudo sobre o tema, tendo em vista que ele vem ocupando cada vez mais espaço na sociedade e dessa forma sua discussão permite que a sociedade tenha maior conhecimento sobre. Além disso, é importante destacar os aspectos positivos que fornece a comunidade científica, pois seu estudo permite e abre portas para desenvolvimento de trabalhos futuros.
Dietary patterns of elementary school students in southern Brazil and associated factors: a cross-sectional school-based study
Authors: Donatti Talita , Henn Ruth Liane , Cremonese Cleber , Loges Letícia , Dell’Osbel Rafaela Santi , Pattussi Marcos Pascoal , Gregoletto Maria Luísa de Oliveira 
Published: January 2023

The objective was to identify dietary patterns and associated factors in schoolchildren from public schools in a city in southern Brazil. Cross-sectional, school-based study (31 schools; 1,750 students, 12-19 years), in the city of Caxias do Sul/Rio Grande do Sul, Brazil. A self-applicable questionnaire was used for data collection. Principal Component Analysis was used to identify dietary patterns and Poisson regression to test associations, considering a statistical significance level of 5% (p≤0.05). Three dietary patterns explained 39.65% of the total variance: Fast Food (19.14%); Fruits & Vegetables (13.15%) and Dairy Products (7.36%). Fast Food pattern was more likely among older students (55%; p=0.036), black/brown (33%; p=0.004), with excessive sedentary behavior (48%; p=0.003), alcohol intake (81%; p<0.001) and more family meals (56%; p=0.027). Fruits & Vegetables was more likely among sufficiently active schoolchildren (33%; p<0.001) and with more family meals (49%; p=0.001), and 30% lower among those with regular self-perceived health (p=0.014). Probability of adherence to the Dairy Products pattern was 23% lower in black/brown skin color (p=0.024); it increased with the maternal education, being higher in adolescents whose mother had completed higher education (67%; p=0.002); it was higher in those with excessive sedentary behavior (55%; p<0.001) and with more family meals (50%; p=0.007). Fast Food pattern was associated with risk behaviors, Fruits & Vegetables pattern to healthy behaviors and Dairy Products pattern to both behaviors. Our findings contribute to the formulation of public policies aimed at promoting healthy eating and other health-promoting behaviors in this population group.
Estudo da vida de prateleira de estruturados da polpa concentrada de jabuticaba
Authors: Fonseca Larissa Ribas , Carvalho Naiara Barbosa , Da Silva Vanelle Maria , Viana Pollyanna Amaral 
Published: January 2023

A jabuticaba possui fibras, vitaminas C e do complexo B, sendo uma fruta rica em sais minerais como, cálcio, fósforo e ferro, com potente ação antioxidante. Estudos de uma técnica de processamento de alimentos denominada estruturação da polpa de frutas tem sido realizados obtendo-se resultados promissores. Essa técnica é uma boa alternativa para garantir as características microbiológicas, nutricionais e sensoriais mais próximas do produto in natura, possibilitando redução dos desperdícios de grandes safras e proporcionando o desenvolvimento de produtos inovadores, convenientes e com alto valor agregado. Neste trabalho foi realizado o estudo de estruturados da polpa concentrada de jabuticaba pelo uso da técnica de shelf-life em diferentes temperaturas (5, 25 e 35 °C), no período de 120 dias. Durante o acompanhamento da vida útil foram realizadas análises físico-químicas (pH e acidez titulável), microbiológicas (coliformes totais, fungos filamentosos e leveduras) e sensoriais (teste de aceitação e intenção de compra) dos estruturados, nos dias 0, 15, 40, 60, 80, 100 e 120, a fim de identificar as características que mais afetaram a qualidade dos produtos. As análises de pH e acidez dos estruturados durante os 120 dias apresentaram-se com médias iguais a (3,86 ± 0,07) e (1,02 ± 0,03) g ácido cítrico/100 g de amostra, respectivamente. Nas temperaturas de 5 e 25 °C os estruturados mantiveram-se adequados para o consumo durante os 120 dias. Os dados cinéticos, Ea (14,33 kcal/mol) e Q10 (1,86), estabelecidos no teste acelerado, permitiram estimar o limite da vida útil em 107 dias para o produto armazenado a 25 °C e 405 dias para o produto armazenado a 5 °C, com a formulação contendo glicose (F1). Entretanto, na temperatura de 35 °C, os estruturados foram considerados impróprios para o consumo, acima de 83 dias, devido a alterações nas características sensoriais, principalmente no sabor. Dessa forma, a elaboração de estruturados de frutas possibilitou a obtenção de um produto com maior vida útil, praticidade e características sensoriais próximas da fruta in natura, podendo ser utilizados na produção de caldas, sorvetes, confeitarias, geleias e iogurtes bicamadas.
Identifikasi Mikroalga sebagai Indikator Pencemaran Lingkungan Air di Perairan Sungai Umala Ogena Kota Baubau
Authors: Sari Yustika , Iksan Muhammad , Slamet Agus 
Published: January 2023

The Umala Ogena River is one of the most famous waterways in Baubau City. During the Sultanate, this river was the economic lifeblood of the Buton people. Rivers are used for various purposes, including transportation, bathing, and washing. If the river ecology is disturbed, all living organisms that exist will be threatened with extinction. Water pollution is the entry of living things, chemicals, energy, or other components into water, thereby reducing water quality. Phytoplankton are microscopic creatures that live on the surface of the water and are classified as plants. The Umala Ogena River is in a mild to moderate polluted phase with organic and inorganic pollutants. This occurs as a result of polluting chemicals found in domestic sewage polluting waterways.
Pragmatisme Kebijakan Luar Negeri Mesir dalam Menyikapi Konflik Rusia-Ukraina
Authors: Nurwijayati Putri Padmi , Machmudi Yon 
Published: January 2023

Abstract
Russia's invasion of Ukraine resulted in the impact of the global economic crisis in various parts of the world, especially those who depend on imports of natural resources and energy from the two countries in conflict. As a country whose food staple is wheat, Egypt felt the economic impact of this military invasion because most of the country's grain imports came from Russia and Ukraine via the Black Sea trade route. The disrupted supply chain caused the price of bread to rise, a situation that had not occurred since the days of President Anwar Sadat. Egypt must take the right attitude in making foreign policy and choose between the great powers controlled by America and its allies or Russia and its allies. This article aims to analyze the steps taken by Egypt in dealing with this dilemma. Using a qualitative method, the author finds that Egypt's foreign policy is pragmatic, in which El Sisi's government supports countries that help him. The authors also provides several recommendations related to principles and steps that can be taken by Egypt.
Keywords: Egypt, foreign policy, geopolitics, pragmatism, Russia, Ukraine
Abstrak
Invasi Rusia ke Ukraina mengakibatkan dampak krisis ekonomi global di berbagai dunia terutama mereka yang menggantungkan impor sumber daya alam dan energi dari kedua negara yang berkonflik. Sebagai negara yang berbahan pokok pangan gandum, Mesir merasakan dampak ekonomi akibat invasi militer ini sebab sebagian besar impor gandum negara ini berasal dari Rusia dan Ukraina, melalui jalur perdagangan Laut Hitam. Rantai pasokan yang terganggu menyebabkan harga roti naik, sebuah situasi yang tidak pernah terjadi sejak zaman Presiden Anwar Sadat. Mesir harus mengambil sikap yang tepat dalam pengambilan kebijakan luar negeri dan memilih antara kekuatan besar yang dikendalikan oleh Amerika dengan sekutunya atau Rusia dan sekutunya. Artikel ini bertujuan untuk menganalisis langkah yang dilakukan Mesir dalam menghadapi dilema ini. Dengan menggunakan metode kualitatif, penulis menemukan bahwa kebijakan luar negeri Mesir adalah pragmatis, dimana pemerintahan El Sisi mengambil sikap untuk mendukung negara yang membantunya. Penulis juga memberikan beberapa rekomendasi terkait dengan prinsip dan langkah yang bisa diambil oleh Mesir.
Kata kunci: geopolitik, kebijakan luar negeri, Mesir, pragmatisme, Rusia, Ukraina
SOSIALISASI PROTOKOL KESEHATAN 5M DI MASA PANDEMI SECARA DARING
Authors: Ihsani Irfan , Meutia Wita , Osly Prima Jiwa , Rafliansyah Farhan 
Published: January 2023

Various efforts have been made to reduce the rate of the spread of Covid. In Indonesia, the government has made a health protocol known as 5M which consists of washing hands, wearing masks, maintaining distance, staying away from crowds, and reducing mobility (Ministry of Health of the Republic of Indonesia). The purpose of this Community Service is to increase public understanding regarding the 5M health protocol. This activity was carried out by distributing 5M posters online for residents of Jl. J. Buntu RT. 005 RW.012 Kec. Tebet, Kel. Kebon Baru, City of Jakarta, DKI Jakarta. With the distribution of posters related to the 5M health protocol online, residents' understanding of health protocols increases and residents are expected to follow the health protocols.

Keywords: 5M, COVID-19, Health Protocol
POLITIK PEMBENTUKAN UNDANG-UNDANG OTONOMI KHUSUS PAPUA DAN PENERAPANNYA PADA MASYARAKAT ADAT KABUPATEN TELUK BINTUNI
Authors: Maria Leonita Dhea 
Published: January 2023

Penulisan hukum ini bertujuan untuk mengkaji politik hukum perundang-undangan ditinjau dari Undang-undang otonomi khusus papua barat NO 2 TAHUN 2021 pasal 38 untuk perekonomian serta pemerataan dan kemakmura masyarat adat papua dengan memperhatikan sumberdaya alam dan ekosistemnya. Apakah uu otonomi khusus itu berhasil atau tidak Ketika di terapkannya di kabupaten teluk bintuni. Artikel ini difokuskan pada, apakah efektif undang-undang tersebut khususnya pada masyarakat adat dikabupaten teluk Bintuni.
PENGARUH UKURAN, PERTUMBUHAN DAN UMUR OBLIGASI PERUSAHAAN TERHADAP PERINGKAT OBLIGASI
Authors: Rianto  , Herman Felani  , Ameilia Damayanti  
Published: January 2023

This study aims to determine the effect of variable size companies , growth companies and maturity against bond rating service sector listed in BEI 2015-2019 period. The population in this study is bond property and real estate companies listed in BEI 2015-2019 period totaling 7 companies. The sampling technique used was purposive sampling. Technical analysis of the data used is the logistic regression analysis with the help of SPSS 17 for windows. Results of the analysis showed that the partial significant effect on the bond ratings, the company's growth is not effect on the bond rating, the maturity is not effect on the bond rating
Keywords: rating bonds,size, growth, and maturity
FAKTOR – FAKTOR YANG MEMPENGARUHI CAPITAL STRUCTURE DAN FINANCIAL PERFORMANCE (Studi pada perusahaan Manufaktur Sub Sektor Industri Barang Konsumsi Yang Terdaftar 2015 -2019)
Authors: Setiawan Temy , Aprilya Cindy 
Published: January 2023

ABSTRAKPertumbuhan ekonomi berperan penting dalam memperlancar proses pembangunan. Salah satu sektor perusahaan manufaktur yang turut serta dalam meningkatkan sekaligus menjadi tulang punggung perekonomian adalah sektor industri barang konsumsi dimana sektor ini perlu diperhatikan agar dapat memaksimalkan financial performance. Namun seiring dengan adanya kenaikan pertumbuhan ekonomi dan nilai investasi, financial performance malah mengalami perlambatan. Oleh karena itu, penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi financial performance pada perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia. Penelitian ini bersifat kuantitatif dan menggunakan metode penelitian PLS-SEM (Partial Least Square - Structural Equation Modeling) dengan data sekunder sebagai sumber data serta purposive sampling sebagai teknik pemilihan sampel. Hasil penelitian mengemukakan bahwa terdapat pengaruh antara capital structure terhadap financial performance dan market value added terhadap financial performance dimana firm size tidak berpengaruh terhadap financial performance, firm size dan market value added tidak berpengaruh terhadap capital structure serta capital structure tidak memiliki peran sebagai variabel mediasi antara variabel firm size dan market value added terhadap financial performance.
Kata kunci : Firm size, market value added, capital structure, financial performance
TO SURVIVE OR NOT : CRISIS MANAGEMENT STRATEGY OF OBAJA TOUR TRAVEL AGENCY DURING PANDEMIC
Authors: Fidya Nurul Hasanah , Gunadi I Made Adhi , Erfinda Yosi 
Published: January 2023

As a result of the COVID-19 pandemic, many business sectors have been disrupted, including the tourism business which hitted the most. This research aim to examine the strategy of Obaja Tour as one of established travel agencies in dealing with the crisis during the COVID-19 pandemic. The type of research used is qualitative methods with a descriptive analysis approach. The data collection obtained by conducting interviews, literature study, and observation. The collected data was validated by triangulation method. The findings show that Obaja Tour managed to survive and still does their function as a travel agency during the pandemic. Obaja Tour is currently in the Resolution and Feedback stage, by continuing to carry out activities such as previous operations and using Adaptive Strategies to facing the crisis through making slight modifications of the company's operations by creating new types of business such as Health Care, Food Service, and Cycling Equipment.
Keywords: Covid-19, pandemic, crisis management, travel agency.