bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human equilibrative nucleoside transporter 1 (hENT1) and deoxycytidine kinase (DCK) are predictive biomarkers for Gemcitabine-based chemoradiotherapy in resected pancreatic cancer patients: a retrospective cohort study
Authors: Elsherif Abdelhalim A. , Kodama Yuzo , Uza Norimitsu , Hussein Mohammed S. , Elhawary Mostafa 
Published: June 2023

Background and Aim
Pancreatic cancer is reported to be one of the cancer-related deaths all over the world. Gemcitabine has been identified as one of the important therapies of malignant diseases. Gemcitabine cellular uptake is allowed by the transporter protein, human equilibrative nucleoside transporter 1 (hENT1). Gemcitabine is phosphorylated by deoxycytidine kinase (dCK) to its active metabolites intracellularly. This study aimed to determine retrospectively the correlation between hENT1 and dCK expression by immunohistochemistry and the overall survival outcome in pancreatic cancer patients who underwent resection and received gemcitabine chemotherapy postoperatively.

Materials and methods
The immunohistochemical analysis was accomplished on samples from 140 patients, who underwent pancreatic cancer resection and was treated by gemcitabine. Immunostaining was done by two expert pathologists and both are blind to patient’s characteristics. The intensity of staining of the tumor determines the scoring for hENT1 and dCK.

Results
Of the 140 tissue samples, 73 (52.1%) had detectable hENT1 cell membrane immunostaining and 67 samples (47.8%) without detectable hENT1. Patients who showed no significant hENT1 immunostaining had a median survival of 6 months, while patients who showed significant hENT1 staining had a median survival longer by 17 months. Of the 140 tissue samples, 52 (37.1%) had detectable dCK cytoplasmic immunostaining and 88 samples (62.9%) without detectable dCK. Patients who showed no significant dCK immunostaining had a median survival of 6.57 months, while patients who showed significant dCK staining had a median survival longer by 19 months.

Conclusion
In patients who received gemcitabine after pancreatic resection, a high expression of hENT1 and dCK are significantly correlated with a longer survival. In addition, in patients who underwent pancreatic cancer resection, immunohistochemical analysis of hENT1 and dCK are considered significant predictive markers to choose patients responding to gemcitabine therapy.
Histopathological Correlations of Serum Prostate Specific Antigen (PSA) and Tumor Grade among Prostate Cancer Patients in Kano, Nigeria
Authors: Abdullahi Abubakar Sarki , Umar Ali Bala , Mohammed Aminu Zakari , Abdulsalam Kabiru 
Published: June 2023

Context:
Prostate cancer is the most common cancer in men of black extraction afflicting mostly the elderly with attendant morbidity and mortality. Prostate specific antigen (PSA) is the most widely used tumor marker for the diagnosis and management of prostate cancer. Patients with raised PSA above 4ng/dl need further evaluation by needle biopsy, and those with cancer are graded using Gleason's score for appropriate prognostication.

Aims:
The study was aimed at establishing a correlation between PSA level and Gleason's tumor grade among patients with prostate cancer.

Settings and Design:
This is a prospective study of prostatic needle biopsies and serum PSA of prostate cancer patients over a period of 1 year.

Materials and Methods:
Venous blood samples for serum PSA were taken and analyzed in the laboratory using an automated in vitro immunoassay analyzer. Patients with raised PSA values (>4 ng/ml) were counseled and consented for trans-rectal needle biopsies and sampled using an 18-gauge biopsy needle; tissue samples were routinely processed and reviewed.

Statistical Analysis:
Statistical analysis was performed by means of statistical package for social sciences (SPSS) software version 21.

Results:
The mean age of patients at presentation was 69 years with a range of 50 to 90 years and mean serum PSA of 78.8ng/dl. The dominant Gleason's scores were 7 and 8 with grade group 5 as the most predominant. There was however no significant correlation between serum PSA and tumor grade.

Conclusions:
Prostatic adenocarcinoma is associated with raised PSA, but tumor grade has no statistical correlation with PSA in patients seen at AKTH, Kano.
Survival and Stage in Lung Cancer
Authors: İNAN Kubilay , ŞENGÜL İNAN Merve , AYTEKİN ÇELİK İlknur , YİLDİZ Ozgur Omer , KARAOGLANOGLU Nurettin 
Published: June 2023

Aim of study:
Lung cancer is the leading cause of cancer death worldwide. Although the 5-year survival rates of for non-small cell lung carcinoma (NSCLC) ranges from 20% to 70%. The present study investigates the rates of early recurrence in a total of 83 patients operated for NSCLC and presents the related findings in reference to the data available in the literature.
Materials and Methods:
Patients who underwent lung resection for malignancy between March 2019 and September 2021 were retrospectively examined. The patient data, including age, gender, presence of preoperative chemotherapy administration, operations performed, operation dates, pathology results, postoperative staging, survival, and relapses, were documented. Ethical approval for this study was obtained from the ethics committee of Ankara Bilkent City Hospital. Approval number is E1-20-817
Results:
A total of 83 patients who underwent lung resection for malignancy between March 2019 and September 2021 were examined. The patients had a median age of 62 years. Of the total number of patients four patients developed recurrence and 79 continued their follow-up without any recurrence. Of the patients who underwent lung resection, eight (9.6%) patients died within the first postoperative 2-year period. The mean survival period of these eight patients was 14.6 months (7–20 months).
Conclusion:
Although various parameters, such as age, gender, pathological type, and location of the tumor are examined and compared, according to the available data on the long-term survival of surgical patients, it is known that the only parameter that affects survival is the pathological stage of the patient.
Time Strategies of Virtual Communities
Authors: Martyanov Denis S. , Lukyanova Galina V. 
Published: June 2023

The Internet has a significant impact on the perception of time and its organization. There is a growing body of literature that recognizes the importance of measuring social time in relation to the virtual communities of social media. The dynamics of communication in virtual communities largely depend on the time strategies that shape the content plan of a particular medium. Based on contemporary theories such as the concept of ‘timeless time’, we analyze the features of the temporal characteristics of the Internet, considering the multiple dimensions of time in virtual communities.
This study aims to identify time strategies depending on their types (e.g., belonging to the certain platform, or target audience). The research is based on posts from 99 politicized virtual communities on the Vk.com and Telegram platforms in 2022. We employ heatmaps and combine them with cluster analysis. As a result, certain patterns of temporal strategies within communities became apparent, depending on the hour, day of the week, and month. We also establish a connection between time strategies and the event context of 2022.
This article may be of interest to sociologists, political scientists, and researchers in cultural and communication studies who are interested in applied aspects of social time research.
The Water Myth in Cinema
Authors: Şahin Murat 
Published: June 2023

This study aims to explore the portrayal of the Fountain of Youth and the myth of the Flood in movies. Firstly, the meaning of the water myth is explained. Then, the focus shifts to how the myth of the Fountain of Youth and the Flood are depicted in different mythologies. The study utilizes qualitative method and thematic content analysis, selecting six films through purposive sampling. The analysis incorporates Joseph Campbell’s Monomyth theory and Klaus Koch’s work on the eight features of the apocalypse. The study reveals how these myths are reproduced through sub-themes identified within the main themes of the Fountain of Youth and the Flood. The results indicate that films present the myth of the Fountain of Youth in various forms. Heroes have different motivations for seeking the Fountain of Youth and encounter various obstacles. Characters who reach the Fountain of Youth undergo significant positive transformations. In flood narratives depicted in movies, the cause of the flood and the awareness of it differ from film to film. Furthermore, other movie findings illustrate who boarded the ship or vehicle to escape the flood and who faced punishment.
A STUDY OF SOME PROPERTIES FOR CELLULAR-LINDELOF TOPOLOGICAL SPACES
Authors: YEOH WEI SHENG  , SALLEH ZABIDIN 
Published: June 2023

Based on Bella and Spadaro (2017), a topological space T is called cellular-Lindelof if for every family F of pairwise disjoint nonempty open subsets of T, there exists a Lindelof subspace L subset T such that F intersection L ≠ empty set for every F∈F.
The aim of this paper is to investigate the properties of cellular Lindelof spaces, its relation with other spaces and find cardinal inequality for cellular-Lindelof spaces based on the Erdos and Rado theorem. The concept of cellular-Lindelof was utilized to show the properties of cellular-Lindelof spaces and its relation with other spaces. We obtain few examples of topological spaces which are not cellular-Lindelof. Erdos and Rado theorem is a theorem based on intersecting set families. Cardinal inequality that was found is based on lemma from Erdos and Rado theorem and information obtained from some journal papers. The study of cellular-Lindelof spaces is the extension study of Lindelof spaces and this is important as it can become a reference material for the future researchers. The central object of the study of topological dynamics is a topological dynamical system, where topological spaces needed. Thus, the study of cellular-Lindelof spaces is also important to the field of dynamical system.
CHRISTOPHER NOLAN SİNEMASININ ARKETİPSEL ANALİZİ
Authors: SUNAL Gözde , KELEŞ Berkan Şahin 
Published: June 2023

Amaç: Bu çalışma, auteur bir yönetmen olan Christopher Nolan’ın yazıp yönettiği filmlerinin arketipsel analizidir. Çalışma kapsamında Nolan filmleri Jungcu bir bakış açısı ile arketipler bağlamında incelenecektir. Nolan’ın filmlerindeki ortak olan Zaman, Baba, Adalet, Âşık, Masum, Tanrı ve Yaşlı Bilge arketipleriyle yönetmenin filmlerinin evrensel ana hatlarının yorumlanması hedeflenmektedir. Bu doğrultuda bu çalışmanın yapılmasındaki amaç Christopher Nolan sinemasındaki ortak arketiplerin ortaya çıkarılmasıdır.
Yaklaşım: İsviçreli bir psikolog olan ve psikolojinin ayrı bir bilim dalı olmasını sağlayan üç isimden (Sigmund Freud, Alfred Adler) birisi olan Carl Gustav Jung’un arketipler kuramına göre, tüm insanların zihinlerinde paylaştıkları ortak bir bilinçdışı vardır ve arketipler de insan zihninde bulunan bu kolektif bilinçdışı alanın yapısını meydana getirirler. Arketiplerin özü, biçimi bilinemez olsa da sahip oldukları özellikler görüntü olarak rüyalarda, mitlerde, öykülerde, efsanelerde, kitaplarda ve filmlerde ortaya çıkarlar. En yaygın görülen arketiplerse kahraman ve gölge arketipleridir. Bu iki arketip hikayelerde kendilerini ana karakter ve kötü karakter olarak gösterirler. Ancak, Aristocu klasik anlatının da temelini oluşturan bu mevcudiyetin Nolan filmleri için geçerli olmadığı bu çalışma kapsamında varsayılmaktadır. Bunun sonucunda da küresel ölçekte farklı kültür ve toplumlarda karşılık ve beğeni bulan Nolan filmlerinin evrensel yönlerinin neler olduğu sorusu meydana çıkmıştır. Söz konusu soru da bu çalışmanın eksenini oluşturmaktadır. Çalışmanın yöntemi, Psikolog Carl Gustav Jung’un Analitik Psikoloji’si çatısı altında bulunan, Arketipsel Analizdir.
Bulgular: Çalışma sonucunda Christopher Nolan sinemasındaki ortak arketiplerin Zaman, Baba, Adalet, Âşık, Masum, Tanrı ve Yaşlı Bilge arketipleri oldukları ortaya çıkmıştır.
Özgünlük: Çalışmanın yönetmen sinemasının okuma ve analizine farklı bir perspektif kazandıracağı düşünülmektedir
Le double mouvement de l’âme vers l’image
Authors: Dekoninck Ralph 
Published: June 2023

Le présent article envisage une controverse philosophico-théologique interne à l’Église catholique qui, au milieu du XVIe siècle, précède et annonce les débats qui présideront à la préparation du décret sur les saintes images promulgué lors de la dernière (25e) session du concile de Trente. Il porte en particulier sur l’un des principaux points d’achoppement qui touche à l’interprétation d’une thèse de Thomas d’Aquin, laquelle est une reprise, mais adaptée à un autre contexte, d’un texte d’Aristote. Cette thèse porte sur le type de vénération qui doit être rendu à l’image, et en particulier à celle du Christ. Il s’agit ici de montrer comment ce débat entremêle étroitement des enjeux philosophiques et théologiques qui touchent aussi bien à des questions de perception de l’image que de connaissance par l’image, tout en engageant un délicat questionnement sur les pratiques religieuses.
Pengaruh Keputusan Investasi terhadap Nilai Perusahaan dengan Struktur Modal sebagai Variabel Intervening pada Perusahaan Food & Beverage yang Terdaftar di BEI
Authors: Rizkiwati Nadila , Anwar Muhadjir 
Published: June 2023

Company value is a certain condition of the company after several years of operation, which is an indicator of public trust in the company. The purpose of the study is to determine whether investment decisions in food and beverage companies listed on the IDX for the 2018-2021 period can affect company value through capital structure as an intervening variable. In this study using quantitative research. For the study, only 24 companies were selected from 32 food and beverage companies. Purposive sampling is the sampling method used in this study. Path Analysis is the method of analysis used. The results of the study show that Investment Decisions contribute to Company Value. Capital Structure is not able to be an intervening variable in the influence of investment decisions on Company Value.
Keywords: Investation decision; Capital Structure; The value of the company.
Ecos de Electra de Sófocles e Electra de Eurípedes em Otra Electra de Edith Ibarra
Authors: Zanotelli Dias da Silva Bartira 
Published: June 2023

Neste trabalho é analisado como o texto dramático Otra Electra da escritora mexicana Edith Ibarra retoma as duas obras gregas clássicas denominadas Electra, a de Sófocles e a de Eurípedes, em um texto atual e crítico. Observamos como Ibarra aborda as principais questões do mito de Electra (o relacionamento conflituoso com sua mãe, o relacionamento com o irmão, o assassinato da mãe) na contemporaneidade. Comparamos trechos das três obras para identificarmos quais aspectos do mito grego ecoam na obra de Ibarra, bem como quais novos elementos entram na versão mexicana. Como base teórica, utilizamos os estudos de Brandão, Garcia Gual e Grimal sobre mitologia e literatura, bem como os estudos de Jung e Hendrika Halberstadt-Freud sobre psicanálise.
ÁREA CONTAMINADA EM OBRA DE CONSTRUÇÃO DE TÚNEL NO MUNICÍPIO DE SÃO PAULO E O PROCESSO DE JUDICIALIZAÇÃO POR DANO AMBIENTAL
Authors: TAKIYA Harmi , MOTTA Milton Tadeu , SIMONETTI Ricardo , QUINTANILHA Jose Alberto , BERSSANETI Fernando Tobal 
Published: June 2023

O objetivo deste trabalho é apresentar um estudo de caso referente à uma área contaminada por compostos BTEX, oriundos de posto de combustível, e sua interferência na fase de execução de obra em via de grande circulação no Município de São Paulo, contribuindo para a prevenção de novas ocorrências. Foram instrumentos da pesquisa análise documental em órgãos ambientais e vistorias no local. A construção da obra foi exigida na Licença Ambiental Prévia da Operação Urbana Faria Lima. A área se situa sobre sedimentos quaternários, aquífero livre, nível d'água raso. Durante sua execução, em 2004, confirmou-se a presença de contaminantes trazendo prejuízos à municipalidade e expondo trabalhadores. Após a obra viária, foram removidos os tanques de combustível do posto e elaborado plano de intervenção de mudança de uso da área para residencial e comercial. O trabalho conclui que a legislação publicada em 2009 e 2013 apresenta avanços ao impor obrigatoriedade de investigação do solo no processo de licenciamento ambiental. A Empresa Municipal de Urbanização em 2004 ingressou com ação judicial de reparação de danos. A ação foi procedente em primeira instância, e encontra-se em análise. Entretanto, para prevenção de novos casos, é necessário intensificar a fiscalização e o controle ambiental de empreendimentos.
Dose uncertainty due to energy dependence in dual-energy
computed tomography
Authors: Kawahara Daisuke , Toyoda Takatoshi , Yokomachi Kazushi , Fujioka Chikako , Nagata Yasushi 
Published: June 2023

PurposeTo evaluate the absolute dose uncertainty at 2 different energies and for the large and small bowtie filters in dual-energy computed tomography (DECT).Material and methodsMeasurements were performed using DECT at 80 kV and 140 kilovoltage peak (kVp), and single-energy computed tomography (CT) at 120 kV. The absolute dose was calculated from the mass-energy absorption obtained from the half-value layer (HVL) of aluminium.ResultsThe difference in the water-to-air ratio of the mean mass energy-absorption coefficients at 80 kV and 140 kV was 2.0% for the small bow-tie filter and 3.0% for the large bow-tie filter. At lower tube voltages, the difference in the absorbed dose with the large and small bow-tie filters was larger.ConclusionsThe absolute dose uncertainty due to energy dependence was 3.0%, which could be reduced with single-energy beams at 120 kV or by using the average effective energy measurement with dual-energy beams.
POZZOLAN EFFECT ON THE MECHANICAL PROPERTIES OF SCBA BLENDED CEMENT TREATED SOIL
Authors: Keria Roziah , N Kok Shien , M.A Farzana , S Siti Fatimah , A Azura 
Published: June 2023

The recent agricultural and industrial waste reduction research has focused on monetary, sustainable environment, and technological considerations. Discarded raw materials such as rice husk ash, fly ash, coir fiber and silica fumes were widely explored and successfully utilized as blending elements for cement. Current studies have proved that Sugarcane Bagasse Ash (SCBA) produced from sugar production has a pozzolanic reaction due to the high substance of amorphous silica in this raw material. This research would boost the insight of potential blending agents that can reduce the cost and stabilize problematic soil. This study intends to evaluate the effect of SCBA blended cement on improved soil’s mechanical properties, including the shear strength and the compressibility of the treated soil. Unconfined Compressive Strength test was conducted to attain the compressive behavior, while the One-Dimensional test was performed to examine the compressibility behavior. The tested samples with SCBA show a beneficial effect in terms of both compressive strength and compressibility. This study proved that SCBA could be applied at least as a partial substitute to the Portland cement.
Insolvenzen weiter rückläufig
Authors: Vetter Bernhard 
Published: June 2023

Frankfurt a.M. Die Zahlen der Insolvenzen in der Landwirtschaft und bei den Herstellern von Nahrungs- und Futtermitteln sind seit vielen Jahren im Durchschnitt rückläufig. Das ist überwiegend positiv zu bewerten – aber nicht ausschließlich.
Pengaruh Persepsi Investasi Saham Syariah Terhadap Minat Berinvestasi Mahasiswa (Studi Pada Galeri Investasi Syariah (GIS) Perguruan Tinggi Islam di Provinsi Jambi)
Authors: Rianto Rino , Fhadilah Ainil 
Published: June 2023

Investasi merupakan kegiatan usaha yang mengandung resiko karena ada unsur ketidakpastian. Dalam pandangan Islam investasi merupakan salah satu pengetahuan mempunyai peranan penting dalam perekonomian. Dengan berinvestasi harta yang kita miliki menjadi produktif dan juga mendatangkan manfaat bagi orang lain. Rumusan masalah dalam penelitian ini adalah Apakah terdapat pengaruh yang signifikan antara persepsi investasi saham Syariah terhadap minat berinvestasi mahasiswa pada Galeri Investasi Syariah di Perguruan tinggi islam provinsi jambi. Hasil penelitian ini menunjukan bahwa persepsi investasi saham Syariah berpengaruh posotif dan signifikan terhadap minat berinvestasi mahasiswa. Hal ini diperoleh dari hasil statistik uji regresi dengan nilai t-hitung sebesar 4,283, dengan nilai signifikansi sebesar 0,000 lebih kecil dari 0,050 dan koefisien regresi mempunyai nilai positif sebesar 0,502.
DOGECOIN PRICE VOLATILITY AFTER ECONOMIC RECOVERY ON COVID-19 PANDEMIC
Authors: Ilyasin Aditya Rahman  , Teguh Indrakusuma  , Achmad Widodo  , Didi Nuryadin  
Published: June 2023

Dogecoin is a crypto asset created by programmers Jackson Palmer and Billy Markus in 2013 which later as luckycoin fork which is now defunct. For information, a cryptocurrency fork is a tweak to the source code of the blockhain protocol in generating protocols or coins. But it turns out that Dogecoin is only used as a joke currency where when Palmer in 2015 stated his goal in building Dogecoin was not to make money or at first using the dog mascot Shiba Inu as meme coins or jokes (Chohan, 2017). Although considered meme coins, in January 2021 Dogecoin has achieved popularity which It’s an 800% increase (Zack Voell, 2021). However, the world of cryptocurrencies is full of unpredictable especially related to fluctuations in crypto prices. The purpose of this research is to confirm the forecast of degecoin volatility and price after the economic recovery of the Covid 19 pandemic. Quantitative and descriptive analysis using the ARIMA and GARCH time series models to predict a price sequentially are the analytical tools used in this study (Rahman & Wulandari, 2022). The data used is secondary data taken from https://www.investing.com/. This research uses secondary data to determine the volatility and prediction of the Dogecoin price. The result of this study is that Dogecoin shows volatility and for price trend predictions tend to experience an uptrend.
Keywords: Dogecoin, Volatility, Covid-19 Pandemic.
The MULTIPLE INTELLIGENCES OF PRIMARY SCHOOL STUDENTS ACCORDING TO HOWARD GARDNER IN THE PERSPECTIVE OF ISLAMIC EDUCATION
Authors: Jumiati Eti 
Published: June 2023

Penelitian ini bertujuan untuk mengetahui kecerdasan majemuk (multiple intelligences) siswa sekolah dasar dalam perspektif pendidikn Islam. Multiple intellegence yang disampaikan Howard Gardner tersebut tercakup juga dalam kecerdasan konsep Islam, meliputi kecerdasan intelektual dan kecerdasan emosional. Namun Howard Gardner tidak melibatkan kecerdasan eksistensial dalam mengungkap kecerdasan yang dimiliki setiap manusia. Padahal Islam memandang kecerdasan eksistensial merupakan salah satu dari kecerdasan yang dimiliki manusia yang berasal dari fitrah manusia.
Jenis penelitian yang digunakan adalah penelitian library research atau kepustakaan. Adapun teknik pengumpulan data yang digunakan adalah riset pustaka atau studi pustaka yaitu memanfaatkan sumber perpustakaan untuk memperoleh data.
Yang membedakan kecerdasan majemuk menurut Howard Gardner dan Perspektif Islam adalah menurut konsep Islam ada konsep alam di dalam pembelajaran. Alam adalah kemampuan dasar yang ada pada masing-masing siswa yang perlu dikembangkan untuk mencapai perkembangan sempurna melalui pendidikan yang tepat. Masalah yang bisa dilihat, bahwa studi agama belum mengembangkan berbagai potensi atau kecerdasan majemuk secara penuh. Pendidikan Islam harus memperhatikan waktu dalam kegiatan belajar dan sesuai dengan ajaran Islam yang sebenarnya. Agar memahami kecerdasan majemuk secara optimal dan berkembang, maka kecerdasan majemuk ini harus juga diterapkan pada pendidikan Islam, sehingga siswa mengetahui kapan potensi kecerdasan bisa ditingkatkan yang pada akhirnya bisa memanfaatkan keterampilannya dalam kehidupan sehari-hari.
Kata Kunci: Multiple Intellegences, Pendidikan Islam