bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ion Conduction in Composite Polymer Electrolytes: Potential Electrolytes for Sodium‐Ion Batteries
Authors: Xu Xiaoyu , Wang Yumei , Yi Qiang , Wang Xinyu , Paredes Camacho Ramon Alberto , Kungl Hans , Eichel Ruediger A. , Lu Li , Zhang Huangwei 
Published: January 2023

AbstractSodium‐ion batteries (SIBs) are expected to become alternatives to lithium‐ion batteries (LIBs) as next‐generation rechargeable batteries, owing to abundant sodium sources and low cost. However, SIBs still use liquid organic electrolytes (LOEs), which are highly flammable and have the tendency to leak. Although inorganic solid electrolytes (ISEs) and solid polymer electrolytes (SPEs) have been investigated for many years, given their higher safety level, neither of them is likely to be commercialized because of the rigidity of ISEs and the low room‐temperature ionic conductivity of SPEs. During the last decade, composite polymer electrolytes (CPEs), composed of ISEs and SPEs, exhibiting both relatively high ionic conductivity and flexibility, have gained much attention and are considered as promising electrolytes. However, the ionic conductivities of CPEs are still unsatisfactory for practical application. Hence, this Review focuses on the principle of sodium ion conductors and particularly on recent investigations and development of CPEs.
Topoclimate effect on treeline elevation depends on the regional framework: A contrast between Southern Alps (New Zealand) and Apennines (Italy) forests
Authors: Rita Angelo , Saracino Antonio , Cieraad Ellen , Saulino Luigi , Zotti Maurizio , Idbella Mohamed , De Stefano Carlo , Mogavero Valentina , Allevato Emilia , Bonanomi Giuliano 
Published: January 2023

AbstractDeciphering the spatial patterns of alpine treelines is critical for understanding the ecosystem processes involved in the persistence of tree species and their altitudinal limit. Treelines are thought to be controlled by temperature, and other environmental variables but they have rarely been investigated in regions with different land‐use change legacies. Here, we systematically investigated treeline elevation in the Apennines (Italy) and Southern Alps (New Zealand) with contrasting human history but similar biogeographic trajectories, intending to identify distinct drivers that affect their current elevation and highlight their respective peculiarities. Over 3622 km of Apennines, treeline elevation was assessed in 302 mountain peaks and in 294 peaks along 4504 km of Southern Alps. The major difference between the Southern Alps and Apennines treeline limit is associated with their mountain aspects. In the Southern Alps, the scarcely anthropized Nothofagus treeline elevation was higher on the warmer equator‐facing slopes than on the pole‐facing ones. Contrary to what would be expected based on temperature limitation, the elevation of Fagus sylvatica treelines in the Apennines was higher on colder, pole‐facing slopes than on human‐shaped equator‐facing, warmer mountainsides. Pervasive positive correlations were found between treeline elevation and temperature in the Southern Alps but not in the Apennines. While the position of the Fagus and Nothofagus treelines converge on similar isotherms of annual average temperature, a striking isothermal difference between the temperatures of the hottest month on which the two taxonomic groups grow exists. We conclude that actual treeline elevation reflects the ecological processes driven by a combination of local‐scale topoclimatic conditions, and human disturbance legacy. Predicting dynamic processes affecting current and future alpine treeline position requires further insight into the modulating influences that are currently understood at a regional scale.
An efficient congestion control in multimedia streaming using adaptive BRR and fuzzy butterfly optimization
Authors: Samiayya Duraimurugan , Ramasamy Jayabharathi , Gunasekar Manikandan 
Published: January 2023

AbstractRecently, various video streaming platforms such as YouTube, Netflix and so forth have achieved great growth in the media industry. However, uncertain dynamic activities such as low bandwidth, packet loss and rapid fluctuations, quality, and interrupted flow are still creating several complications in multimedia streaming applications and it is necessary to provide enhanced throughput and minimum frame delivery delay. Therefore, the significant objective of this article is to attain enhanced bandwidth allocation as well as a high packet scheduling rate. In this article, an adaptive BBR technique is proposed for transmitting real‐time video with minimum transmission delay and packet loss. The adaptive BBR mainly uses the pacing gain update mechanism to maintain different flow rates and minimal data in the bottleneck queue. Also, a fuzzy butterfly optimization (FBO) with a ranking strategy is proposed to attain optimal bandwidth allocation. The FBO algorithm with ranking strategy computes the minimal bandwidth needed by the model to satisfy the service requirement of every queue in a particular round. Then, the packet scheduling is done by employing an intelligent time slice‐based round‐robin (ITSBRR) technique. The ITSBRR algorithm is employed to enhance the throughput and end‐to‐end delay by implementing the time quantum‐based scheduling mechanism. Finally, the experimental analysis is carried out for various parameters namely single path transmission delay, packet loss; frame delay is computed for various techniques to compute the efficiency of the proposed system.
Ultrasmall iron‐gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging‐guided ischemia stroke therapy
Authors: Du Yujing , Huo Yan , Yang Qi , Han Zhihui , Hou Linqian , Cui Bixiao , Fan Kevin , Qiu Yongkang , Chen Zhao , Huang Wenpeng , Lu Jie , Cheng Liang , Cai Weibo , Kang Lei 
Published: January 2023

AbstractOxidative stress from reactive oxygen species (ROS) is a reperfusion injury factor that can lead to cell damage and death. Here, ultrasmall iron‐gallic acid coordination polymer nanodots (Fe‐GA CPNs) were developed as antioxidative neuroprotectors for ischemia stroke therapy guided by PET/MR imaging. As proven by the electron spin resonance spectrum, the ultrasmall Fe‐GA CPNs with ultrasmall size, scavenged ROS efficiently. In vitro experiments revealed that Fe‐GA CPNs could protect cell viability after being treated with hydrogen peroxide (H2O2) and displayed the effective elimination of ROS by Fe‐GA CPNs, which subsequently restores oxidation balance. When analyzing the middle cerebral artery occlusion model, the neurologic damage displayed by PET/MR imaging revealed a distinct recovery after treatment with Fe‐GA CPNs, which was proved by 2,3,5‐triphenyl tetrazolium chloride staining. Furthermore, immunohistochemistry staining indicated that Fe‐GA CPNs inhibited apoptosis through protein kinase B (Akt) restoration, whereas western blot and immunofluorescence indicated the activation of the nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1) pathway following Fe‐GA CPNs application. Therefore, Fe‐GA CPNs exhibit an impressive antioxidative and neuroprotective role via redox homeostasis recovery by Akt and Nrf2/HO‐1 pathway activation, revealing its potential for clinical ischemia stroke treatment.
Effects of tree age on flavonoids and antioxidant activity in Torreya grandis nuts via integrated metabolome and transcriptome analyses
Authors: Yan Jingwei , Zeng Hao , Chen Weijie , Zheng Shan , Luo Jiali , Jiang Huifeng , Yang Baoru , Farag Mohamed A. , Lou Heqiang , Song Lili , Wu Jiasheng 
Published: January 2023

AbstractThe nuts of Torreya grandis are abundant in flavonoids, providing potential antioxidant activity. Considering that T. grandis can yield nuts for hundreds or thousands of years, effects of tree age on flavonoids and antioxidant activity of T. grandis nuts were targeted in this study for the first time. Results revealed that antioxidant activity and total flavonoid contents in 100‐ and 1000‐years‐old T. grandis nuts were much higher compared to 10‐years‐old T. grandis. The content of 19 flavonoids showed significant correlations with antioxidant activity in 100‐ and 1000‐years‐old trees using metabolites profiling. Transcriptome and coexpression analysis indicated that seven genes were associated with aged‐related flavonoids biosynthesis. Further analysis showed that abscisic acid and gibberellin might regulate the age‐related differential flavonoids accumulation. Our study provides a novel viewpoint that aged T. grandis is likely to present a better source of natural antioxidants and has yet to be examined in other tree models.
Trajectories of psychological distress during the COVID‐19 pandemic among community‐dwelling older adults in Quebec: A longitudinal study
Authors: Matovic Sara , Grenier Sébastien , Jauvin Florence , Gravel Catherine , Vasiliadis Helen‐Maria , Vasil Nancy , Belleville Sylvie , Rainville Pierre , Dang‐Vu Thien Thanh , Aubertin‐Leheudre Mylène , Knäuper Bärbel , Dialahy Isaora Zefania , Gouin Jean‐Philippe 
Published: January 2023

AbstractObjectiveThe COVID‐19 pandemic and its associated public health measures may increase the risk for psychological distress among vulnerable older adults. This longitudinal study aimed to identify predictors of psychological distress trajectories among community‐dwelling older adults in Quebec, Canada.MethodsThe study spanned four time points across 13 months and three waves of the COVID‐19 pandemic. The sample included 645 community‐dwelling older adults ages 60 years and older in Quebec. Participants completed telephone‐based interviews that included the Kessler 6‐item Psychological Distress Scale (K6) to assess psychological distress at each time point as well as information on socioeconomic, medical, psychological and COVID‐19 related factors. Group‐based trajectory modelling was used to identify distinct trajectories of psychological distress across time.ResultsThree group‐based trajectories of psychological distress were identified: the resilient (50.5%), reactive (34.9%), and elevated distress groups (14.6%). Individuals with mobility issues, insomnia symptoms, COVID‐19 related acute stress, general health anxiety, increased loneliness symptoms, and those unable to use technology to see others were more likely to be in the reactive and elevated groups than the resilient group. Those with past mental health problems had uniquely increased odds of being in the reactive group compared to the resilient group. Individuals living in poverty and those who reported taking psychotropic medication had increased odds of being in the elevated distress group compared to the resilient group.ConclusionThese findings characterized distinct trajectories of psychological distress in older adults and identified risk factors for elevated distress levels.
Reevaluating the role of the hippocampus in memory: A meta‐analysis of neurotoxic lesion studies in nonhuman primates
Authors: Waters Spencer J. , Basile Benjamin M. , Murray Elisabeth A. 
Published: January 2023

AbstractThe hippocampus and perirhinal cortex are both broadly implicated in memory; nevertheless, their relative contributions to visual item recognition and location memory remain disputed. Neuropsychological studies in nonhuman primates that examine memory function after selective damage to medial temporal lobe structures report various levels of memory impairment—ranging from minor deficits to profound amnesia. The discrepancies in published findings have complicated efforts to determine the exact magnitude of visual item recognition and location memory impairments following damage to the hippocampus and/or perirhinal cortex. To provide the most accurate estimate to date of the overall effect size, we use meta‐analytic techniques on data aggregated from 26 publications that assessed visual item recognition and/or location memory in nonhuman primates with and without selective neurotoxic lesions of the hippocampus or perirhinal cortex. We estimated the overall effect size, evaluated the relation between lesion extent and effect size, and investigated factors that may account for between‐study variation. Grouping studies by lesion target and testing method, separate meta‐analyses were conducted. One meta‐analysis indicated that impairments on tests of visual item recognition were larger after lesions of perirhinal cortex than after lesions of the hippocampus. A separate meta‐analysis showed that performance on tests of location memory was severely impaired by lesions of the hippocampus. For the most part, meta‐regressions indicated that greater impairment corresponds with greater lesion extent; paradoxically, however, more extensive hippocampal lesions predicted smaller impairments on tests of visual item recognition. We conclude the perirhinal cortex makes a larger contribution than the hippocampus to visual item recognition, and the hippocampus predominately contributes to spatial navigation.
Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods
Authors: Jordaens Stephanie , Zwaenepoel Karen , Tjalma Wiebren , Deben Christophe , Beyers Koen , Vankerckhoven Vanessa , Pauwels Patrick , Vorsters Alex 
Published: January 2023

AbstractThe aim of this review was to explore the status of urine sampling as a liquid biopsy for noninvasive cancer research by reviewing used preanalytical parameters and protocols. We searched two main health sciences databases, PubMed and Web of Science. From all eligible publications (2010‐2022), information was extracted regarding: (a) study population characteristics, (b) cancer type, (c) urine preanalytics, (d) analyte class, (e) isolation method, (f) detection method, (g) comparator used, (h) biomarker type, (i) conclusion and (j) sensitivity and specificity. The search query identified 7835 records, of which 924 unique publications remained after screening the title, abstract and full text. Our analysis demonstrated that many publications did not report information about the preanalytical parameters of their urine samples, even though several other studies have shown the importance of standardization of sample handling. Interestingly, it was noted that urine is used for many cancer types and not just cancers originating from the urogenital tract. Many different types of relevant analytes have been shown to be found in urine. Additionally, future considerations and recommendations are discussed: (a) the heterogeneous nature of urine, (b) the need for standardized practice protocols and (c) the road toward the clinic. Urine is an emerging liquid biopsy with broad applicability in different analytes and several cancer types. However, standard practice protocols for sample handling and processing would help to elaborate the clinical utility of urine in cancer research, detection and disease monitoring.
Identification of Covalent Ligands – from Single Targets to Whole Proteome
Authors: Ngo Chau , Ekanayake Arunika , Zhang Chao 
Published: January 2023

AbstractThere has been a surge of interest and efforts in the discovery of covalent ligands for diverse proteins as tool compounds or therapeutic candidates in recent years. We present two studies that involve applications of a target‐centric approach and a ligand‐centric approach toward covalent ligand discovery. By targeting a rare cysteine residue in a receptor tyrosine kinase EphB3, we were able to rapidly identify potent inhibitors of EphB3 with extraordinary proteomic selectivity supported by activity‐based probe profiling. While characterizing an activity‐based probe intended for EphB3 using ABPP, we made a surprising discovery that its primary cellular target was a catalytic subunit of V‐ATPase through its covalent engagement with a cryptic pocket on V‐ATPase. These two approaches will be increasingly used in combination to develop covalent ligands with high potency and yield comprehensive target profiles to accelerate the rate of therapeutic discovery in the future.
Wafer‐scale patterned growth of type‐II Dirac semimetal platinum ditelluride for sensitive room‐temperature terahertz photodetection
Authors: Dong Zhuo , Yu Wenzhi , Zhang Libo , Yang Liu , Huang Luyi , Zhang Yan , Ren Zeqian , Mu Haoran , Chen Cheng , Zhang Junrong , Li Jie , Wang Lin , Zhang Kai 
Published: January 2023

AbstractAs the lastly unexplored electromagnetic wave, terahertz (THz) radiation has been exploited in a plenty of contexts such as fundamental research, military and civil fields. Most recently, representative two‐dimensional (2D) topological semimetal, platinum ditelluride (PtTe2) has attracted considerable research interest in THz detection due to its unique physical properties. However, to achieve practical applications, the low‐cost, large‐scale, controllable synthesis and efficient patterning of 2D materials are key requirements, which remain a challenge for PtTe2 and its photodetectors (PDs). Herein, a facile approach is developed to obtain wafer‐scale (2‐inches) patterned PtTe2 arrays using one‐step tellurium‐vapor transformation method and micro‐Nano technology. PtTe2 PD arrays are fabricated with the as‐grown PtTe2 arrays evenly distributed on a 2‐inch wafer, exhibiting high conductivity (~2.7 × 105 S m−1) and good electrical consistency. Driven by the Dirac fermions, PtTe2 PDs achieve a broadband (0.02–0.3 THz) response with a fast response speed (~4.7 μs), a high sensitivity (~47 pW Hz−1/2) and high‐resolution transmission THz‐imaging capability, which displays the potential of large‐area THz array imaging. These results are one step towards the practical applications of integrated PD arrays based on 2D materials.image
Adjusted versus unadjusted earnings: An empirical analysis of pro forma adjustments in large German public companies
Authors: Wiek Marcel , Eichner Korbinian 
Published: January 2023

AbstractThis article analyzes non‐GAAP, pro forma earnings metrics of large German publicly traded companies to better understand their usage and relevance in practice. We base our analysis on a hand collected data set compiled from annual reports. Almost all companies in our data set use pro forma earnings. Typically, legal, restructuring, acquisition and accounting related costs get adjusted. EBIT, EBITDA, EPS and Net income are the most frequently adjusted earnings metrics. In almost all observed cases, pro forma earnings are higher than their underlying GAAP earnings. Our study addresses the challenge of investors to understand a company's “true” operating performance. Only when one understands the historically observable financial performance, one can make better predictions of its recurring, future financial performance. The article adds to the existing literature by analyzing in which part of the annual report pro forma earnings are typically disclosed, how transparent they are presented and reconciled, and what impact adjustments have compared to the unadjusted GAAP earnings.
Auditor tax expertise and corporate tax avoidance: Evidence from Taiwan
Authors: Liu Wu‐Po , Ma Mengyu , Liu Zhenfeng , So Chun Yin 
Published: January 2023

AbstractThe link between auditor tax expertise and corporate tax avoidance is investigated in this study. Using a sample of Taiwanese listed firms from between 2005 and 2019, it is found that companies that hire auditor tax experts engage in a higher level of tax avoidance. The results also show that this association is more pronounced among firms that have subsidiaries registered in tax havens. The findings of this study show that this positive association between auditor tax expertise and corporate tax avoidance can be mitigated through the adoption of IFRS. This study makes a contribution to existing literature by using a unique Taiwanese setting to study the tax avoidance effect of auditor tax experts and the effect of a common tax avoidance technique have on tax savings.
Ceftriaxone induces glial EAAT‐2 promotor region via NF‐kB conformational changes: An interaction analysis using HADDOCK
Authors: Rao Gaddam Narasimha , Jupudi Srikanth , Pant Pradeep , Palathoti Nagarjuna , Rajagopal Kalirajan , Govindasamy Rathika , Justin Antony 
Published: January 2023

AbstractExcitotoxicity, depletion of energy metabolites, and ionic imbalance are the major factors involved in neurodegeneration mediated through excitatory amino acid transporter‐2 (EAAT‐2) dysfunction in ischemic insult. Recent studies have revealed that ceftriaxone expresses EAAT‐2 via nuclear transcription factor kappa‐B (NF‐kB) signaling pathway, stimulation of EAAT‐2 expression in the ischemic, and excitotoxic conditions that could provide potential benefits to control neurodegeneration. In this study, we have predicted the in silico model for interaction between NF‐kB and EAAT‐2 promoter region to rule out the conformational changes for the expression of EAAT‐2 protein. Using homology‐built model of NF‐kB, we identified ceftriaxone‐induced conformational changes in gene locus −272 of DNA where NF‐kB binding with EAAT‐2 promoter region through protein−DNA docking calculation. The interaction profile and conformational dynamics occurred between ceftriaxone predocked and postdocked conformations of NF‐kB with DNA employing HADDOCK 2.2 web server followed by 250 ns long all atom explicit solvent molecular dynamics simulations. Both the protein and DNA exhibited modest conformational changes with respect to HADDOCK score, energy terms (desolvation energy [Edesolv]), van der waal energy (Evdw), electrostatic energy (Eelec), restraints energy (Eair), buried surface area, root mean square deviation, RMSF, radius of gyration, total hydrogen bonds when ceftriaxone pre‐ and postdocked NF‐kB conformations were bound to DNA. Hence, the conformational changes in the C‐terminal domain could be the reason for EAAT‐2 expression through ceftriaxone specific binding pocket of −272 of DNA.
Computational analysis of geometric structures and edge‐termination effects of boron‐nitride and edge‐termination boron‐nitride nanoribbons
Authors: Wang Houng‐Wei , Lu Shih‐I , Wang Bo‐Cheng 
Published: January 2023

AbstractIn this work, we examined geometry, electronic structure, and edged termination effect of boron‐nitride nanoribbons (BNNRs) by employing localized Gaussian‐type orbital, periodic‐boundary condition, density functional theory (LGTO‐PBC‐DFT) calculations. Armchair (ABNNR) and zigzag (ZBNNR)‐type BNNRs are obtained and then bond lengths variation in two types of BNNRs are analyzed. We find that the B‐N bond length variation of ZBNNR is less diverse than that of ABNNR, and decreases with an increase in the ribbon width, monotonically. For those in ABNNR, it appears as an oscillatory convergence as a function of the ribbon width. The energy gap of edged termination ABNNR and ZBNNRs are also calculated using OH and SH as electron donating groups and CN‐, and Cl‐ as electron‐withdrawing groups. The introduction of SH‐ and Cl‐terminator significantly reduce the energy gap to the semiconducting region for ZBNNR, but for ABNNR. These calculated results may be exploited for nano‐electronic applications. To examine the surface behavior of the BNNRs, we also calculated their Raman shifts with the edge termination effects.