bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on 1H-NMR spectroscopy
Authors: Qiu Yaopeng , Xu Zhou , Xie Qingfeng , Zhang Renyi , Wang Luyao , Zhao Liying , Liu Hao 
Published: February 2023

Abstract
Background
Lipid metabolism dysregulation is a prominent metabolic alteration in various cancers. The study aimed to explore the association of plasma lipid metabolism profiles with overall survival (OS) for gastric cancer (GC) patients who received gastrectomy.

Methods
GC patients who were treated with gastrectomy and measured with plasma lipid metabolism profiles using proton nuclear magnetic resonance (1H-NMR) spectroscopy in Nanfang Hospital between January 1, 2017, and October 31, 2018, were recruited. The Least Absolute Shrinkage and Selection Operator (LASSO) regression model was used to analyze variables selected by univariate analysis for OS. An index of plasma lipid metabolism profiles, named plasma lipid metabolism index (PLMI), was constructed by variables' coefficients in LASSO regression to explore its association with OS and its role in the prediction model.

Results
A total of 158 GC patients were included in this study. Four of the 110 lipid profiles, including LDL-5 Apo-B, LDL-4 Cholesterol, HDL-4 Apo-A2, and HDL-4 Free Cholesterol, were selected to construct the PLMI. The optimal cut-off value of PLMI for OS was used to classify the population into two subgroups, the high PLMI group (≥ − 0.163) and the low PLMI group (< − 0.163). The high PLMI group had a shorter OS (p = 0.0034) and was the independent risk factor for OS (Hazard Ratio = 2.13, 95% Confidence Interval (CI): 1.07–4.22, p = 0.031) after adjusting for perineural invasion and tumor stage. In subsets of the I–III stage and treating postoperative chemotherapy, high PLMI also had an unfavorable correlation with OS (p = 0.016 and p = 0.0086, respectively). The nomogram prediction models of both the training cohort and validation cohort showed good calibration and discrimination with the concordance indexes of 0.806 (95% CI, 0.732–0.880) in the training cohort and 0.794 (95% CI, 0.725–0.862) in the validation cohort.

Conclusions
This study found that the index derived from the LDL-5 Apo-B, LDL-4 Cholesterol, HDL-4 Apo-A2, and HDL-4 Free Cholesterol, was significantly associated with overall survival, suggesting that regulating lipid metabolisms might improve the prognosis for GC patients.
Three dimensional condylar positional and morphological changes following mandibular reconstruction based on CBCT analysis: a prospective study
Authors: Al-Wesabi Saddam Noman , Abotaleb Bassam , Al-Shujaa Eissa Abdo , Mohamed Abdo Ahmed , Alkebsi Khaled , Telha Wael , Jian Sun , Fuqiang Xie 
Published: February 2023

Abstract
Objective
This study aimed to evaluate the condylar positional changes following mandibular reconstruction with preservation of the condylar head using Cone-Beam Computed Tomography (CBCT). Also, to assess joint space changes and the overall volumetric space compared to the preoperative status.

Methodology
This prospective study included 30 patients (60 joints) subjected to unilateral mandibular resection and reconstruction with preservation of the condylar head. The Helkimo index and preoperative (T1), two weeks postoperative (T2), and follow-up CBCTs (T3) after at least six months were gathered and processed to evaluate the condylar position and TMJ joint space using Anatomage Invivo 6. A student’s t-test and repeated-measures ANOVA statistics were used. A P value of less than 0.05 was considered statistically significant.

Results
Thirty patients (14 males, 16 females) with a mean age of 40.01 ± 12.7 years (a range of 18.1–62.9 years) were included. On the tumor side, there were significant variances in the vertical and mediolateral condylar positions between the three-time points (T1, T2, T3). Immediately after the operation, the condyles were significantly displaced in a downward direction at T2, which became larger after the last follow-up period (T3) (p = 0.007). The condylar positions at the anteroposterior direction were relatively stable without significant differences between the three times points (p = 0.915). On the non-tumor side, the condylar positions were relatively stable in the mediolateral and anteroposterior positions.
In the tumor side, all of the TMJ spaces were significantly increased in size following the mandibular reconstructions (T2 and T3). However, on the non-tumor side, the anterior, posterior, and medial joint spaces were significantly changed postoperatively.

Conclusion
After mandibular reconstruction with condylar preservation, the condylar position and volumetric measurement immediately changed noticeably and continued to be a permanent change over time compared to relatively stable condyles on the non-tumor side. According to Helkimo index, patients become adapted to the postoperative changes without significant differences between the two sides.
Easy surgical explantation technique for sutureless Perceval S prosthesis, ‘lasso technique’: a case report
Authors: Kim Yun Seok , Yoo Jae Suk 
Published: February 2023

Abstract
Background
Due to structural valve deterioration of sutureless aortic prosthesis, there is a need for explantation of the prothesis. We introduce a surgical technique to explant sutureless aortic prosthesis, which has a self-expanding stent incorporated into the aortic wall.

Case presentation
An 82-year-old man who had undergone sutureless aortic valve replacement 6 years previously underwent redo-aortic and mitral valve replacement because of severe prosthetic aortic valve stenosis and mitral regurgitation. The sutureless prosthesis was explanted using ‘lasso technique’. The patient was discharged after 7 days without complications.

Conclusions
We presented a useful technique to explant a sutureless aortic prosthesis.
Age, geographical and socio-economic related inequalities in contraceptive prevalence: evidence from the 1993–2014 Ghana Demographic and Health Surveys
Authors: Mensah Felix , Okyere Joshua , Azure Simon Agongo , Budu Eugene , Ameyaw Edward Kwabena , Seidu Abdul-Aziz , Ahinkorah Bright Opoku 
Published: February 2023

Abstract
Background
Contraceptives afford individuals the opportunity to meet their reproductive needs and reduce maternal mortality. We aimed at assessing the trend and inequalities of contraceptive use in Ghana based on the 1993–2014 Ghana Demographic and Health Surveys.

Methods
We used the World Health Organization’s Health Equity Assessment Toolkit (HEAT) software in analysing the data. We adopted two approaches for the analysis. First, we disaggregated inequalities in contraceptive use using four equity stratifiers: wealth index, education, residence, and region. Second, summary measures (D), (PAR), (R), and (PAF) were also employed. A 95% uncertainty interval (UI) was constructed for point estimates to measure statistical significance.

Results
Contraceptive prevalence increased from 20.3% in 1993 to 26.7% in 2014. The contraceptive prevalence among women aged 20–49 increased from 20.6% [95% UI = 19.1, 22.3] in 1993 to 26.8% [95% UI = 24.9, 28.9] in 2014 and this exceeded the increase that was recorded among those aged 15–19 (from 13% [95 UI = 8.7, 19] to 18% [95% UI = 11.5, 28.6]), in the same period. It was evident that substantial inequality existed with respect to contraceptive use, from 1993 to 2014, with widest inequality occurring in 2003 (PAF = 2.7, 95% UI = -16.6–21.9; D = 17.4, 95% UI = 12.7–22.1). In terms of wealth index, the least inequality was observed in 2014 (PAR = 1.3, 95% UI = -1–3.6; D = 5.9, 95% UI = -0.1–12). Regarding education, the widest inequality occurred in 1993 (PAF = 138.6, UI = 132.1–145.1; D = 40.1, 95% UI = 34.4–45.9). With place of residence, the widest gap in inequality occurred in 1993 (PAF = 51.2, 95% UI = 46.2–56.3; D = 15.3, 95% UI = 11.8–18.7). There was inequality in contraceptive use with respect to sub-national regions. In 2014, the Difference (D = 21, 95% UI = 14.6–27.4) and the PAF (PAF = 20.9, 95% UI = 11.2 − 30.5) measures revealed substantial absolute and relative regional inequality between the regions.

Conclusion
There was a steady increase in contraceptive use from 20.3% in 1993 to 26.7% in 2014. Nevertheless, the percentage change is minimal. The trends of inequality indicate that inequalities in contraceptive use was evident across the dimension of age, place of residence, wealth index, education, and region. Yet, there was a substantial reduction in inequalities related to contraceptive use in 2014. Therefore, targeting adolescents, women in rural areas, low wealth quintile, and those with no formal education is key to substantially improving contraceptive use across the country.
Novel Algorithm for the Estimation of Cancer Incidence Using Claims Data in Japan: A Feasibility Study
Authors: Ogawa Toshio , Takahashi Hirokazu , Saito Hiroshi , Sagawa Motoyasu , Aoki Daisuke , Matsuda Kazuo , Nakayama Tomio , Kasahara Yoshio , Kato Katsuaki , Saitoh Eiko , Morisada Tohru , Saika Kumiko , Sawada Norie , Matsumura Yasushi , Sobue Tomotaka 
Published: February 2023

PURPOSE We developed algorithms to identify patients with newly diagnosed cancer from a Japanese claims database to identify the patients with newly diagnosed cancer of the sample population, which were compared with the nationwide cancer incidence in Japan to assess the validity of the novel algorithms. METHODS We developed two algorithms to identify patients with stomach, lung, colorectal, breast, and cervical cancers: diagnosis only (algorithm 1), and combining diagnosis, treatments, and medicines (algorithm 2). Patients with newly diagnosed cancer were identified from an anonymized commercial claims database (JMDC Claims Database) in 2017 with two inclusions/exclusion criteria: selecting all patients with cancer (extract 1) and excluding patients who had received cancer treatments in 2015 or 2016 (extract 2). We estimated the cancer incidence of the five cancer sites and compared it with the Japan National Cancer Registry incidence (calculated standardized incidence ratio with 95% CIs). RESULTS The number of patients with newly diagnosed cancer ranged from 219 to 17,840 by the sites, algorithms, and exclusion criteria. Standardized incidence ratios were significantly higher in the JMDC Claims Database than in the national registry data for extract 1 and algorithm 1, extract 1 and algorithm 2, and extract 2 and algorithm 1. In extract 2 and algorithm 2, colorectal cancer in male and stomach, lung, and cervical cancers in females showed similar cancer incidence in the JMDC and national registry data. CONCLUSION The novel algorithms are effective for extracting information about patients with cancer from claims data by using the combined information on diagnosis, procedures, and medicines (algorithm 2), with 2-year cancer-treatment history as an exclusion criterion (extract 2).
How Resilient Are Firms’ Financial Reporting Processes?
Authors: deHaan Ed , de Kok Ties , Matsumoto Dawn , Rodriguez-Vazquez Edgar 
Published: February 2023

The timely flow of financial information is critical for efficient capital market functioning, yet we have little understanding of firms’ and auditors’ collective abilities to maintain timely financial reporting when under duress. We use COVID as a stress test case to examine whether reporting systems can withstand systemic increases in complex economic events and coordination challenges. Despite COVID-related challenges persisting through 2020 and beyond, we document surprisingly modest average delays in financial reports during COVID and only in Q1-2020. Reporting timeliness reverts to pre-COVID levels no later than Q2-2020. We find no evidence of meaningful declines in actual reporting quality during COVID, but we do find some evidence consistent with declines in perceived reporting quality. Overall, our findings indicate that current financial reporting processes are remarkably robust and provide insights about financial reporting more broadly. In particular, given that nearly all firms were able to weather the unprecedented disruptions caused by COVID, our findings imply that most material reporting delays observed outside of COVID are likely a result of either a firm’s strategic choices or exceptionally fragile reporting processes. This paper was accepted by Ranjani Krishnan, accounting. Supplemental Material: The data and online appendix are available at https://doi.org/10.1287/mnsc.2023.4670 .
Have telemedicine consultations been beneficial as follow-up appointments for people with multiple sclerosis?
Authors: Tredwell Bethan 
Published: February 2023

Introduction: This study ascertained whether telemedicine appointments have been beneficial for follow-up appointments for people who have multiple sclerosis (MS). The Covid-19 pandemic forced many services to adapt and change the way in which people with long-term conditions were reviewed. Initially, local MS services employed the use of telephone appointments, but quickly introduced telemedicine appointments, which enabled the clinician and patient to see each other via video technology. The initial feedback from the patients was mixed, with some patients preferring face-to-face appointments and others happy with the change. Since, telemedicine appointments have remained part of many MS services. As restrictions in the country have been lifted, the decision needs to be made whether MS teams across the country continue to use technology in the form of telemedicine appointments or return to face-to-face clinics in the hospital outpatient setting. Methods: A sample of patients were invited to complete an online questionnaire, which was issued through the member list of a local MS therapy centre. A thematical approach was then used to assess the gathered information. Results: The results of the questionnaire showed the preferred type of follow-up appointment was a face-to-face clinical setting, which the majority of participants found more personal, making it easier to communicate with their specialist nurse. However, when asked if they would prefer to be reviewed through face-to-face appointments only, telemedicine appointments only, or a combination of the two, the majority of participants preferred a combination of face-to-face and telemedicine follow ups. Conclusions: This study showed that the rapid uptake of telemedicine during the Covid-19 pandemic was useful to maintain regular reviews of people with MS. However, given the small sample size and limited age range, further research will be required to ascertain whether people with MS find telelmedicince follow-up appointments as beneficial as face-to-face appointments.
Financial Analysis of Innovative Wood Products and Carbon Finance to Support Forest Restoration in California
Authors: Elias Micah , Dees John , Cabiyo Bodie , Saksa Phil , Sanchez Daniel L. 
Published: February 2023

Abstract
Traditional funding strategies of grants, congressional appropriations, and income from timber sales are insufficient to complete the level of forest restoration necessary throughout California. Stimulating investment into markets for low-value biomass—such as tops and branches of trees, small trees, and dead trees—will add value to forest raw materials and provide additional revenue streams to pay for forest restoration. We evaluate the investment potential of products made from low-value biomass using a discounted cash-flow analysis of several possible forest products including fuels and nonfuels under various climate policy and market scenarios. We demonstrate the carbon benefits provided by these products, attributed to their substitution for fossil-fuel feedstocks and long-term carbon storage. Our work finds that there is an opportunity to develop several highly profitable products, most notably fuels, many of which are eligible for energy and climate policy programs such as California's Low Carbon Fuel Standard and the federal Renewable Fuel Standard. Nonfuel products have an average internal rate of return (IRR) of 13 percent, whereas fuels have an average IRR of 19 percent in our baseline scenario. Although products ineligible for government incentives are generally less profitable, income from the voluntary carbon market greatly increases the IRR. Fostering investment into these products can encourage critically needed funding for forest management while developing a high-impact carbon removal solution enabled by state, federal, and voluntary climate initiatives. On this basis, we conclude that climate policy can support forest restoration in California.
Cost-effectiveness analysis of anlotinib versus sunitinib as first-line treatment for metastatic renal cell carcinoma in China
Authors: Lin Jingyang , Fang Qingxia , Zheng Xiaochun 
Published: February 2023

Background
Sunitinib was approved several years ago as a first-line drug for treating metastatic renal cell carcinoma (mRCC); however, its high price and broad side effects when administered at the standard dose have limited its clinical use. A clinical trial (NCT02072031) confirmed that anlotinib could be used as the first-line treatment for mRCC. This study was conducted to evaluate the cost-effectiveness of anlotinib as a first-line treatment for mRCC compared to that of sunitinib in China.

Methods
A Markov model was established to compare the cost-effectiveness of anlotinib with that of sunitinib. Clinical data were obtained from a multi-center phase II trial (clinical trial information: NCT02072031). Utility values were obtained from the literature. Total costs were calculated from a Chinese societal perspective. A sensitivity analysis was conducted to assess the model uncertainty. The life-year (LY), quality-adjusted life-year (QALY), and incremental cost-effectiveness ratio were calculated.

Results
The base-case analysis over a lifetime horizon of 10 years showed that the anlotinib group had 2.196 LYs and 1.487 QALYs at a total cost of $68,597.84. The sunitinib group had 2.194 LYs and 1.432 QALYs at a total cost of $88,060.02. This resulted in incremental cost-effectiveness ratios (ICER) of anlotinib versus sunitinib of $-9,210,858.93 per LYs and $-354,117.07 per QALYs, suggesting that anlotinib is a more effective and less costly strategy than sunitinib.

Conclusion
Anlotinib may be a more cost-effective first-line treatment strategy for mRCC than sunitinib in China.
Evaluating a Novel, Portable, Self-Administrable Device (“Beacon”) That Measures Critical Flicker Frequency as a Test for Hepatic Encephalopathy
Authors: Vutien Philip , Li Richard , Karkar Ravi , Munson Sean A. , Fogarty James , Walter Kara , Yacoub Michael , Ioannou George N. 
Published: February 2023

INTRODUCTION:
We compared critical flicker frequency (CFF) thresholds obtained using a novel portable device “Beacon” with thresholds from the commercially available Lafayette Flicker Fusion System (Lafayette-FFS) in patients with cirrhosis.

METHODS:
One hundred fifty-three participants with chronic liver disease underwent CFF testing using Beacon and Lafayette-FFS with a method-of-limits and/or forced-choice protocol.

RESULTS:
Beacon demonstrated excellent test-retest reliability (intraclass correlation 0.91–0.97) and good correlation with the Lafayette-FFS values (intraclass correlation 0.77–0.84). Forced-choice CFF were on average 4.1 Hz higher than method-of-limits descending CFFs.

DISCUSSION:
Beacon can be self-administered by patients with chronic liver disease and cirrhosis to measure CFF, a validated screening test for minimal hepatic encephalopathy.
História e memória da educação especial em Mato Grosso do Sul: constituição, trilhas e serviços
Authors: Neres Celi Corrêa , Belato Janaina de Jesus Fernandes , Corrêa Nesdete Mesquita 
Published: February 2023

O objetivo deste artigo foi analisar a constituição dos serviços e atendimentos da educação especial no estado de Mato Grosso do Sul (MS), por meio das vozes de duas gestoras pioneiras na condução da implementação de políticas de educação especial. A coleta de dados foi realizada por meio de entrevista com roteiro semiestruturado, após adesão das convidadas à pesquisa, por meio do Termo de Consentimento Livre e Esclarecido (TCLE) e da autorização das mesmas para divulgar suas identidades, para fins de publicação. O tratamento, análise e sistematização dos resultados tiveram como aporte teórico o materialismo histórico. Os resultados apontaram que a educação especial no estado de MS, em confluência com a história da educação especial no Brasil, foi constituída por iniciativas pioneiras, com participação direta de profissionais das áreas da medicina, da psicologia e de instituições especializadas, sendo essas iniciativas tanto de cunho individual como, também, de algumas equipes.
A reference model for common understanding of capabilities and skills in manufacturing
Authors: Köcher Aljosha , Belyaev Alexander , Hermann Jesko , Bock Jürgen , Meixner Kristof , Volkmann Magnus , Winter Michael , Zimmermann Patrick , Grimm Stephan , Diedrich Christian 
Published: February 2023

Abstract
In manufacturing, many use cases of Industrie 4.0 require vendor-neutral and machine-interpretable information models to describe, implement and execute resource functions. Such models have been researched under the terms capabilities and skills. Standardization of such models is required, but currently not available. This paper presents a reference model developed jointly by members of various organizations in a working group of the Plattform Industrie 4.0. This model covers definitions of most important aspects of capabilities and skills. It can be seen as a basis for further standardization efforts.
The Highest Good as the Ideal of Reason in the Canon of the first
Critique
Authors: Filieri Luigi 
Published: February 2023

Abstract
In the Dialectic of the first Critique, Kant claims that a highest being is the transcendental ideal of speculative reason. However, the Canon of the Doctrine of Method presents the highest good as an ideal of both the speculative and the practical use of reason. In this paper, I argue (1) that the highest good is the ideal of the unity of reason – unlike the ideal in the Dialectic – insofar as (2) the highest good serves both the speculative and the practical employment of reason. Accordingly, I also argue that (3) these two employments are complementary, not alternative. Kant’s argument for the ideal of the highest good in the Canon shows that the unity of reason combines the two lawful employments of reason. In order to be reason’s highest ideal, this ideal cannot just mirror the demands of speculative reason – it must also involve the other fundamental employment of reason, i. e., the practical. This highest standpoint cannot be merely speculative but must be moral as well: not just a highest ideal, but also a good (the highest good).
Crystal structure of trans-tetrakis(3-phenylpyridine-κN)bis(thiocyanato-κN)nickel(II), C46H36N6NiS2
Authors: Ha Kwang 
Published: February 2023

Abstract
C46H36N6NiS2, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 9.1007(10) Å, b = 9.8108(10) Å, c = 11.8638(12) Å, α = 107.377(3)°, β = 107.333(3)°, γ = 91.254(4)°, V = 957.84(17) Å3, Z = 1, Rgt
(F) = 0.0248, wRref
(F
2) = 0.0651, T = 223(2) K.