bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transport aircraft — a challenge for aluminium alloys for the 21st century
Authors: Jupp J. A. , Price H. J. 
Published: February 2023

AbstractThe anticipated size of the world airliner market over the period 1997-2016, and the resultant requirements for aluminium plate and extrusions to satisfy potential Airbus wing box production is reviewed.The ‘value’ of technology and the threat posed by polymer composites to the future of aluminium alloys for large transport aircraft wing box structures is discussed and the prospect is raised that there may be limited further development potential for conventional aluminium alloys within the civil transport wing context. This may then force a re-evaluation of the role of aluminium-lithium alloys and other non-conventional metallic materials as alternatives to polymer composites.Opportunities to maximise the cost-effectiveness of advanced aluminium alloys are discussed and the potential benefits of closer co-operation between the aircraft and aluminium industries highlighted within a joint technical and commercial framework.The ‘challenge’ to the aluminium industry is described as a continuing requirement to assist the aircraft manufacturer to offer ‘optimum value’ products to the airlines. Otherwise, alternative technologies such as polymer composites will emerge and the pre-eminent position of aluminium in civil transport aircraft will be eroded.
Neotropical sisterhood: new species ofGyrodactylusvon Nordmann, 1832 (Platyhelminthes: Monogenea) infectingRhamdia guatemalensisandRhamdia laticauda(Siluriformes: Heptapteridae) in Mexico
Authors: García-Vásquez A. , Pinacho-Pinacho C.D. , Guzmán-Valdivieso I. , Calixto-Rojas M. , Rubio-Godoy M. 
Published: February 2023

AbstractWe describe two new species of monogenean parasites of the genusGyrodactylusvon Nordmann, 1832 infecting Neotropical catfishes (Siluriformes) in southern Mexico:Gyrodactylus chulinin. sp. from ‘chulín’,Rhamdia laticaudacollected in Oaxaca; andGyrodactylus juilin. sp. from ‘juil’,Rhamdia guatemalensisfrom Veracruz. Morphologically, both new taxa are similar toGyrodactylusspp. infecting catfishes (Siluriformes) in South America. Sequences of the internal transcribed spacers (ITS1-5.8S–ITS2 rDNA), the D2+D3 domains of the large ribosomal subunit (28S rDNA) and the cytochrome oxidase II (COII) gene were obtained from multiple parasite specimens and analysed using Bayesian inference. Phylogenetic hypotheses using ITS rDNA and COII genes, recovered two newGyrodactylusspecies fromRhamdiaspp.:G. chulinin. sp.; andGyrodactylus juilin. sp., which are sister species toGyrodactylus lilianae, a parasite ofRhamdia quelenin Brazil, and show strong affinity to other gyrodactytlids infecting Neotropical catfishes. This suggests that these new taxa, the first gyrodactylids described fromRhamdiaspp. in Mexico, co-migrated to Tropical Middle America with their Neotropical catfish hosts, after the emergence of the Isthmus of Panama.
Longitudinal patterns and sociodemographic profiles of health-related behaviour clustering among middle-aged and older adults in China and Japan
Authors: Wu Min , Yang Conghui , Zhang Yu'an , Umeda Maki , Liao Jing , Mawditt Claire 
Published: February 2023

AbstractGiven inevitable age-related decreases in physical or mental capacity, studies on health-related behaviour (HRB) clustering in older people provide an opportunity to reduce health-care costs and promote healthy ageing. This study explores the clustering of HRBs and transition probabilities of cluster memberships over time, and compares sociodemographic characteristics of these clusters among Chinese and Japanese middle-aged and older adults. Using the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015 (N = 19614) and the Japanese Study of Ageing and Retirement (JSTAR) from 2007 to 2011 (N = 7,080), Latent Transition Analysis was applied to investigate the clustering and change in clustering memberships of smoking, alcohol consumption, physical activity and body mass index. Multivariate logistic regression was used to explore the sociodemographic characteristics of these longitudinal HRB cluster members. We identified four common clusters in CHARLS and JSTAR: ‘smoking’, ‘overweight or obese’, ‘healthy lifestyle’ and ‘current smoking with drinking’, and an additional cluster named ‘ex-smoking with drinking’ in JSTAR. Although HRB cluster members were largely stable in both cohorts, participants in China tended to move towards an unhealthy lifestyle, while participants in Japan did the opposite. We also found that participants who smoked and drank were more likely to be male, younger, less educated and unmarried in both cohorts, but the overweight or obese participants were female, urban and higher income in CHARLS but not JSTAR. Our study not only contributes to the knowledge of longitudinal changes in health-related behavioural clustering patterns in an Asian elderly population, but may also facilitate the design of targeted multi-behavioural interventions to promote healthy lifestyles among older people in both countries.
Stakeholder preferences for attributes of digital health technologies to consider in health service funding
Authors: von Huben Amy , Howell Martin , Norris Sarah , Wong Kam Cheong , Tang James , Kazi Samia , Laranjo Liliana , Chow Clara K. , Howard Kirsten 
Published: February 2023

Abstract

Objectives
Health service providers are currently making decisions on the public funding of digital health technologies (DHTs) for managing chronic diseases with limited understanding of stakeholder preferences for DHT attributes. This study aims to understand the community, patient/carer, and health professionals’ preferences to help inform a prioritized list of evaluation criteria.

Methods
An online best–worst scaling survey was conducted in Australia, New Zealand, Canada, and the United Kingdom to ascertain the relative importance of twenty-four DHT attributes among stakeholder groups using an efficient incomplete block design. The attributes were identified from a systematic review of DHT evaluation frameworks for consideration in a health technology assessment. Results were analyzed with multinomial models by stakeholder group and latent class.

Results
A total of 1,251 participants completed the survey (576 general community members, 543 patients/carers, and 132 health professionals). Twelve attributes achieved a preference score above 50 percent in the stakeholder group model, predominantly related to safety but also covering technical features, effectiveness, ethics, and economics. Results from the latent class model supported this prioritization. Overall, connectedness with the patient’s healthcare team seemed the most important; with “Helps health professionals respond quickly when changes in patient care are needed” as the most highly prioritized of all attributes.

Conclusions
It is proposed that these prioritized twelve attributes be considered in all evaluations of DHTs that manage chronic disease, supplemented with a limited number of attributes that reflect the specific perspective of funders, such as equity of access, cost, and system-level implementation considerations.
Divisors computing minimal log discrepancies on lc surfaces
Authors: LIU JIHAO , XIE LINGYAO 
Published: February 2023

AbstractLet$(X\ni x,B)$be an lc surface germ. If$X\ni x$is klt, we show that there exists a divisor computing the minimal log discrepancy of$(X\ni x,B)$that is a Kollár component of$X\ni x$. If$B\not=0$or$X\ni x$is not Du Val, we show that any divisor computing the minimal log discrepancy of$(X\ni x,B)$is a potential lc place of$X\ni x$. This extends a result of Blum and Kawakita who independently showed that any divisor computing the minimal log discrepancy on a smooth surface is a potential lc place.
Contesting Master Narratives: Renderings of National History by Mainland China and Taiwan
Authors: Lyu Zhaojin , Zhou Haiyan 
Published: February 2023

AbstractThe growing tension between mainland China and Taiwan has a cultural aspect closely related to national identity. We focus on recent history curriculum changes in the mainland and in Taiwan and find that education authorities on both sides have implemented master narratives for content selection in and organization of history textbooks. In mainland China, the master narrative of pluralist unity constructs a geographically consistent Chinese nation throughout history, which bolsters the state's current claim to a territorial integrity including Taiwan. In Taiwan, the master narrative of multiculturalism becomes the essence of Taiwanese identity, and weakens Sinocentrism in Taiwanese official historiography.
“No Quixotry in Redress of Grievances”: How Community Abatement of Public Nuisances Disappeared from American Law
Authors: Meyer William B. 
Published: February 2023

AbstractBefore 1859, the right of any member of the public to abate a public nuisance existed unchallenged in American law as a judicially recognized form of popular justice. In that year, the decision inBrown v. Perkins, authored by Massachusetts Chief Justice Lemuel Shaw, restricted the right to those who had suffered particular injury. The decision grew out of a suit for damages by the owner of an illegal saloon, which had been sacked by a local mob. Reversing what Shaw himself had said in his charge to the jury in the same suit in the preceding year, it had little grounding in earlier American case law. Shaw's prestige and the apparent demands of public policy, however, helped win courts over to the new doctrine in relatively short order. The change was most enthusiastically promoted by judges and scholars of conservative leanings disturbed by the threat of popular excess and most resisted by those of more radical inclinations. It paralleled American law's broader shift in the same period toward centralized regulation and the constitutionalization of rights and powers.
Folding left and right matters: Direct style, accumulators, and continuations
Authors: DANVY OLIVIER 
Published: February 2023

Abstract
The equivalence of folding left and right over Peano numbers and lists makes it possible to minimalistically inter-derive (1) structurally recursive functions in direct style, (2) structurally tail-recursive functions that use an accumulator, and (3) structurally tail-recursive functions in delimited continuation-passing style, using Ohori and Sasano’s lightweight fusion by fixed-point promotion. When the fold-left and the fold-right functions account for primitive iteration for Peano numbers, this equivalence is unconditional. When they account for primitive recursion for Peano numbers, this equivalence is modulo left permutativity of their induction-step parameter – a property which is more general than associativity and commutativity. And when they account for primitive iteration or for primitive recursion over lists, this equivalence is modulo left permutativity of their induction-step parameter if these two fold functions have the same type. Since the 1980s, however, the two fold functions for lists do not have the same type: the arguments for their induction-step parameter are swapped, a re-ordering that complicated Bird and Wadler’s duality theorems and whose history is reviewed in an appendix. Without this re-ordering, Bird and Wadler’s second duality theorem more visibly accounts for “re-bracketing,” which is a key step to make recursive programs tail recursive in the general area of program development, from Cooper in the 1960s and onwards.
Experimental Constraints on the Rheology of Lavas From 2021 Cumbre Vieja Eruption (La Palma, Spain)
Authors: Di Fiore F. , Vona A. , Scarani A. , Giordano G. , Romano C. , Giordano D. , Caricchi L. , Martin Lorenzo A. , Rodriguez F. , Coldwell B. , Hernandez P. , Pankhurst M. 
Published: February 2023

AbstractThe 2021 Tajogaite eruption of Cumbre Vieja (La Palma, Spain) was typified by the emission of low viscosity lavas that flowed at high velocities and inundated a large area. We experimentally investigated the rheological evolution of melt feeding the eruption through concentric cylinder viscometry to understand the exceptional flowing ability of these lavas and constrain its emplacement dynamics. We conducted a set of cooling deformation experiments at different cooling rates (from 0.1 to 10 °C/min), and isothermal deformation experiments at subliquidus dwell temperatures between 1225 and 1175°C. All experiments were conducted at a shear rate of 10 s−1. Results show that disequilibrium crystallization and its timescale fundamentally control the rheological evolution of the melt, resulting in different rheological response to deformation of the crystal‐bearing magmatic suspension. Integrating rheological data with field observations allows us to shed light on the mechanisms that govern the high flowability of these lavas.
Slow‐Moving Landslides Triggered by the 2016 Mw 7.8 Kaikōura Earthquake, New Zealand: A New InSAR Phase‐Gradient Based Time‐Series Approach
Authors: Cao Yunmeng , Hamling Ian , Massey Chris , Upton Phaedra 
Published: February 2023

AbstractEarthquake‐triggered slow‐moving landslides are not well studied mainly due to a lack of high‐resolution in‐situ geodetic observations both in time and space. Satellite‐based interferometric synthetic aperture radar (InSAR) has shown potential in landslides applications, however, it is challenging to detect earthquake‐triggered slow‐moving landslides over large areas due to the effects of post‐seismic tectonic deformations, atmospheric delays, and other spatially propagated errors (e.g., unwrapped errors caused by decorrelation noises). Here, we present a novel InSAR phase‐gradient‐based time‐series approach to detect slow‐moving landslides that triggered by the 2016 Mw 7.8 Kaikōura earthquake. Twenty‐one earthquake‐triggered large (>0.1 km2) slow‐moving landslides are detected and studied. Our results reveal decaying characteristics of the temporal evolutions of these landslides, that averagely 3.9 years after the earthquake, their post‐seismic velocity will decay by 90% to reach approximately the pre‐seismic level. Our study opens new perspectives for understanding mass balance of earthquakes and helps reduce associated hazards.
The Cross Equatorial Transport of the Hunga Tonga‐Hunga Ha'apai Eruption Plume
Authors: Schoeberl M. R. , Wang Yi , Ueyama R. , Taha G. , Yu W. 
Published: February 2023

AbstractOn 15 January 2022, the Hunga Tonga‐Hunga Ha'apai (HT) eruption injected SO2 and water into the middle stratosphere. Shortly after the eruption, the water vapor anomaly moved northward toward and across the equator. This northward movement appears to be due to equatorial Rossby waves forced by the excessive infrared water vapor cooling. Following the early eruption stage, persistent mid‐stratospheric water vapor and aerosol layers were mostly confined to Southern Hemisphere tropics (Eq. to 30°S). However, during the spring of 2022, the westerly phase of the tropical quasi‐biennial oscillation (QBO) descended through the tropics. The HT water vapor and aerosol anomalies were observed to again move across the equator coincident with the shift in the Brewer‐Dobson circulation and the descent of the QBO shear zone.
m6A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1 manner
Authors: Guan Hua , Tian Kun , Luo Wei , Li Mingfei 
Published: February 2023

AbstractEmerging evidence indicates the critical roles of N6-methyladenosine (m6A) modification in human cancers. Herein, our work reported that a novel m6A-modified circRNA from the MYO1C gene, circMYO1C, upregulated in the pancreatic ductal adenocarcinoma (PDAC). Our findings demonstrated that circMYO1C is highly expressed in PDAC tissues. Functionally, circMYO1C promoted the proliferation and migration of PDAC cells in vitro and its silencing reduced the tumor growth in vivo. Mechanistically, circMYO1C cyclization was mediated by m6A methyltransferase METTL3. Moreover, methylated RNA immunoprecipitation sequencing (MeRIP-seq) unveiled the remarkable m6A modification on PD-L1 mRNA. Moreover, circMYO1C targeted the m6A site of PD-L1 mRNA to enhance its stability by cooperating with IGF2BP2, thereby accelerating PDAC immune escape. In conclusion, these findings highlight the oncogenic role of METTL3-induced circMYO1C in PDAC tumorigenesis via an m6A-dependent manner, inspiring a novel strategy to explore PDAC epigenetic therapy.
Hybrid autoencoder with orthogonal latent space for robust population structure inference
Authors: Yuan Meng , Hoskens Hanne , Goovaerts Seppe , Herrick Noah , Shriver Mark D. , Walsh Susan , Claes Peter 
Published: February 2023

AbstractAnalysis of population structure and genomic ancestry remains an important topic in human genetics and bioinformatics. Commonly used methods require high-quality genotype data to ensure accurate inference. However, in practice, laboratory artifacts and outliers are often present in the data. Moreover, existing methods are typically affected by the presence of related individuals in the dataset. In this work, we propose a novel hybrid method, called SAE-IBS, which combines the strengths of traditional matrix decomposition-based (e.g., principal component analysis) and more recent neural network-based (e.g., autoencoders) solutions. Namely, it yields an orthogonal latent space enhancing dimensionality selection while learning non-linear transformations. The proposed approach achieves higher accuracy than existing methods for projecting poor quality target samples (genotyping errors and missing data) onto a reference ancestry space and generates a robust ancestry space in the presence of relatedness. We introduce a new approach and an accompanying open-source program for robust ancestry inference in the presence of missing data, genotyping errors, and relatedness. The obtained ancestry space allows for non-linear projections and exhibits orthogonality with clearly separable population groups.
Pulmonary recovery from COVID-19 in patients with metabolic diseases: a longitudinal prospective cohort study
Authors: Sonnweber Thomas , Grubwieser Philipp , Pizzini Alex , Boehm Anna , Sahanic Sabina , Luger Anna , Schwabl Christoph , Widmann Gerlig , Egger Alexander , Hoermann Gregor , Wöll Ewald , Puchner Bernhard , Kaser Susanne , Theurl Igor , Nairz Manfred , Tymoszuk Piotr , Weiss Günter , Joannidis Michael , Löffler-Ragg Judith , Tancevski Ivan 
Published: February 2023

AbstractThe severity of coronavirus disease 2019 (COVID-19) is related to the presence of comorbidities including metabolic diseases. We herein present data from the longitudinal prospective CovILD trial, and investigate the recovery from COVID-19 in individuals with dysglycemia and dyslipidemia. A total of 145 COVID-19 patients were prospectively followed and a comprehensive clinical, laboratory and imaging assessment was performed at 60, 100, 180, and 360 days after the onset of COVID-19. The severity of acute COVID-19 and outcome at early post-acute follow-up were significantly related to the presence of dysglycemia and dyslipidemia. Still, at long-term follow-up, metabolic disorders were not associated with an adverse pulmonary outcome, as reflected by a good recovery of structural lung abnormalities in both, patients with and without metabolic diseases. To conclude, dyslipidemia and dysglycemia are associated with a more severe course of acute COVID-19 as well as delayed early recovery but do not impair long-term pulmonary recovery.
Estimation of the visual contribution to standing balance using virtual reality
Authors: Assländer Lorenz , Albrecht Matthias , Diehl Moritz , Missen Kyle J. , Carpenter Mark G. , Streuber Stephan 
Published: February 2023

AbstractSensory perturbations are a valuable tool to assess sensory integration mechanisms underlying balance. Implemented as systems-identification approaches, they can be used to quantitatively assess balance deficits and separate underlying causes. However, the experiments require controlled perturbations and sophisticated modeling and optimization techniques. Here we propose and validate a virtual reality implementation of moving visual scene experiments together with model-based interpretations of the results. The approach simplifies the experimental implementation and offers a platform to implement standardized analysis routines. Sway of 14 healthy young subjects wearing a virtual reality head-mounted display was measured. Subjects viewed a virtual room or a screen inside the room, which were both moved during a series of sinusoidal or pseudo-random room or screen tilt sequences recorded on two days. In a between-subject comparison of 10 $$\times$$
×
6 min long pseudo-random sequences, each applied at 5 amplitudes, our results showed no difference to a real-world moving screen experiment from the literature. We used the independent-channel model to interpret our data, which provides a direct estimate of the visual contribution to balance, together with parameters characterizing the dynamics of the feedback system. Reliability estimates of single subject parameters from six repetitions of a 6 $$\times$$
×
20-s pseudo-random sequence showed poor test–retest agreement. Estimated parameters show excellent reliability when averaging across three repetitions within each day and comparing across days (Intra-class correlation; ICC 0.7–0.9 for visual weight, time delay and feedback gain). Sway responses strongly depended on the visual scene, where the high-contrast, abstract screen evoked larger sway as compared to the photo-realistic room. In conclusion, our proposed virtual reality approach allows researchers to reliably assess balance control dynamics including the visual contribution to balance with minimal implementation effort.
Impact of gene alterations on clinical outcome in young adults with myelodysplastic syndromes
Authors: Konishi Tatsuya , Sadato Daichi , Toya Takashi , Hirama Chizuko , Kishida Yuya , Nagata Akihito , Yamada Yuta , Shingai Naoki , Shimizu Hiroaki , Najima Yuho , Kobayashi Takeshi , Haraguchi Kyoko , Okuyama Yoshiki , Harada Hironori , Ohashi Kazuteru , Harada Yuka , Doki Noriko 
Published: February 2023

AbstractYoung adults with myelodysplastic syndrome (MDS) are rare, and the clinical significance of driver mutations has not yet been analysed. We analysed the gene mutations and copy number alterations (CNAs) in younger MDS patients using next-generation sequencing, targeting 68 genes that were recurrently mutated in myeloid malignancies, to investigate the correlation between their genetic alterations and clinical outcomes. We enrolled 55 patients retrospectively (aged < 50 years). At least one mutation was detected in 56% of the patients. The most frequently mutated genes were ASXL1 and RUNX1, 13% each. We defined higher-risk patients as those with ≥ 2 mutations, except for SF3B1 mutation, and/or CNA. The 3-year overall survival (OS) in patients with a higher-risk was lower than that in those with a lower-risk (50.8% vs. 71.8%, P = 0.024). Among the 44 transplant recipients, patients with higher-risk had a significantly lower OS and tended to have a higher cumulative incidence of relapse (CIR) than those with a lower-risk (3-year OS: 38.0% vs. 64.4%, P = 0.039; 3-year CIR: 44.0% vs. 24.1%, P = 0.076). Our results showed that genetic aberrations can predict clinical outcomes in younger MDS patients, despite the low rate of genetic mutations.