bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colletes hederae bees are equally attracted by visual and olfactory cues of inconspicuous Hedera helix flowers
Authors: Lukas Kathrin , Dötterl Stefan , Ayasse Manfred , Burger Hannah 
Published: September 2023

AbstractWild bees are heavily declining worldwide except for a few species, such as Colletes hederae, which is spreading in its distribution throughout Europe. Colletes hederae mainly forages on ivy (Hedera helix) which is widespread in Europe and the plants’ availability is thought to contribute to the successful spread of C. hederae. A rapid location of the plants using visual and/or olfactory floral cues would allow the bee to efficiently forage. Beside bee visitors, the flowers attract a high variety of other insects, such as Vespula wasps that were recently investigated regarding their floral-cue preferences. The aim of this study was to investigate the communication between C. hederae and its H. helix host flowers, and to compare the results with that previously obtained with V. germanica wasps. We identified headspace compounds detectable by the bees using gas chromatography coupled to electroantennography (GC-EAD) and performed behavioral experiments to both compare the attractiveness of visual and olfactory floral cues and to determine the attractiveness of a synthetic mixture composed of physiologically active compounds. In the GC-EAD analyses, bees responded to 15 flower-specific compounds of various chemical classes, of which 4-oxoisophorone, (E)-linalool-oxide furanoid, and acetophenone were the most abundant in the floral scent. In the bioassays, visual and olfactory flower cues were equally attractive for bees, but a combination of both cues was needed to elicit not only approach responses but also landings. A synthetic mixture of the EAD-active compounds was attractive to the bees, but to a lesser extent than the natural scent of H. helix flowers. The bees’ integrations of different floral-cue modalities in its search image and its strong antennal responses elicited by various floral scent compounds make C. hederae highly effective in finding its host flowers. In comparison to V. germanica wasps, the bees relied stronger on visual cues than the wasps do, but both species showed the highest attraction when presented with a combination of the cues.
Ein geschlechterspezifischer Blick auf das gesundheitsbezogene Informationshandeln, seine Treiber und Barrieren
Authors: Link Elena , Baumann Eva , Aluttis Christoph 
Published: September 2023

Zusammenfassung
Hintergrund
Vor dem Hintergrund der Geschlechterperspektive als relevante Ebene effektiver Gesundheitskommunikation wird das gesundheitsbezogene Informationshandeln fokussiert. Ergänzend zur Informationssuche wird die Informationsvermeidung einbezogen. Beide Formen des Informationshandelns werden geschlechterspezifisch beschrieben und sollen anhand verschiedener Ressourcen wie der Gesundheit, dem Wohlbefinden, dem Empowerment, dem Involvement und der sozialen Unterstützung erklärt werden.

Methode
Es wurde eine Online-Befragung einer für die deutsche Bevölkerung stratifizierten Stichprobe (N = 3000) durchgeführt. Erfasst wurden die beiden Formen des Informationshandelns sowie ihre theoretisch abgeleiteten Prädiktoren. Neben deskriptiven Analysen dienen blockweise Regressionsanalysen dazu, geschlechterspezifisch die Prädiktoren der Suche und Vermeidung zu identifizieren.

Ergebnisse
Die Informationssuche findet häufiger statt als die Informationsvermeidung. Beide unterscheiden sich nur in geringem Maß zwischen Männern und Frauen. Für Suche und Vermeidung zeigen sich die stärksten Zusammenhänge mit dem Involvement der Befragten. Für die Suche sind zudem auch Ressourcen des Bedrohungsmanagements bedeutsam, während die Vermeidung mit dem psychischen Wohlbefinden und der sozialen Unterstützung assoziiert ist. Geschlechterübergreifend zeigen sich ähnliche Assoziationsmuster.

Diskussion
Geschlechterübergreifend zeigt sich, dass mittels gesundheitskommunikativer Maßnahmen das Involvement der Bevölkerung unterstützt und Ressourcen des Bedrohungsmanagements gestärkt werden müssen, um die Suche zu fördern und der Vermeidung entgegenzuwirken. Zudem wird deutlich, dass Vermeider*innen als eine zentrale Zielgruppe mehr Aufmerksamkeit erhalten sollten.
Zertifizierung der Deutschen Gesellschaft für Neurorehabilitation e. V., DGNR
Authors: Platz Thomas , Schmidt-Wilcke Tobias , Groß Martin , Friederich Christian , Pohl Marcus 
Published: September 2023

Zusammenfassung
Hintergrund
Die Zertifizierung von Zentren für Beatmungsentwöhnung in der neurologisch-neurochirurgischen Frührehabilitation (NNFR) durch die Deutsche Gesellschaft für Neurorehabilitation (DGNR) ist seit dem 01.10.2021 möglich.

Ziel der Arbeit
Die Ergebnisse der Zertifizierung von Einrichtungen im ersten Jahr nach Aufnahme des Verfahrens werden vorgestellt.

Material und Methoden
Im Rahmen der Zertifizierung werden 28 Kriterien geprüft, darunter eine Reihe mandatorisch zu erfüllender Charakteristika der Einrichtung. Die Kriterien gliedern sich in Strukturkriterien (i = 7), Diagnostikkriterien (i = 6), Personalkriterien (i = 3), Kriterien der internen Organisation (i = 7) und Qualitätsmanagementkriterien (i = 5).

Ergebnisse
Insgesamt 13 Zentren wurden im ersten Jahr zertifiziert, die zusammen über 283 Betten zur Beatmungsentwöhnung („weaning“) in der NNFR verfügen und im Jahr vor der Zertifizierung 2278 Personen im Weaning betreuten, im Median pro Einrichtung 134 (Bereich [Min-Max] 44–414). Nur selten war das Weaning nicht erfolgreich, sodass vor Entlassung auf eine Heimbeatmung eingestellt werden musste (invasive Heimbeatmung Median pro Einrichtung 10 Personen, Bereich 2–25; nichtinvasive Heimbeatmung Median 0 Personen, Bereich 0–57). Festgestellt wurde ein hohes Maß an Prozess- und Strukturqualität in den zertifizierten Zentren: Über alle Prüfbereiche hinweg waren die Prüfkriterien zu allermeist erfüllt (Median Erfüllungsgrad 86 %) bzw. erfüllt mit von den Auditor*innen dokumentierten Verbesserungspotenzialhinweisen (Median 11 %).

Schlussfolgerung
Erfolgreiches Weaning in der NNFR und ein hohes Maß an Prozess- und Strukturqualität lassen sich anhand der Zertifizierungsergebnisse der Zentren belegen, die diesen integrativen Ansatz bei der Beatmungsentwöhnung verfolgen.
Grain refinement of aluminium welds by Ti, TiB$$_2$$, and TiC filler wire inoculation
Authors: Kirkbakk Kjell Martin , Marhaug Nikolai , Kvam-Langelandsvik Geir , Werenskiold Jens Christofer 
Published: September 2023

AbstractA fine-grained fusion zone characterises a tough aluminium weld. To improve the solidification characteristics and refine the grains in aluminium welding, different inoculation particle combinations were introduced to the filler wire by solid state metal screw extrusion. Filler wires were I-joint welded with two different welding methods to reveal the potency for grain refinement. Grain size, microstructure, porosity content, and hardness across the weld was revealed. Gas metal arc welding with a Ti-TiC inoculated filler wire exhibited a remarkable grain refinement of 91% compared to a base reference of commercial pure aluminium. The Al$$_3$$

3

Ti intermetallic phase was found as nucleation point. Gas tungsten arc welding showed lower grain refinement potency, and no Al$$_3$$

3

Ti phase was found in any weld. Thus, the effect of welding method must be taken into consideration upon development of inoculant containing filler wires.
Sex-specific foraging behaviour in a long-lived seabird
Authors: Militão Teresa , Kürten Nathalie , Bouwhuis Sandra 
Published: September 2023

AbstractSex-specific foraging behaviour may lead to differences between the sexes in both resource acquisition and exposure to threats and thereby contribute to sex-specific reproductive roles or mortality. As such, it is important to identify in which species sex-specific foraging behaviour occurs. We deployed GPS devices to incubating common terns (Sterna hirundo) from a German breeding population to study how sex and spatial or temporal extrinsic factors influence the daily activity budget, foraging distribution, and trip characteristics of this slightly sexually size dimorphic seabird. Birds of both sexes only foraged during the day, showing peaks of activity after sunrise and before sunset, perhaps in response to temporal variation in prey availability and/or as a strategy to overcome or prepare for nocturnal fasting. Furthermore, foraging was more frequent around low tide and at the beginning of the flood tide and mainly occurred in shallow (< 5 m depth) and coastal waters (< 2 km from coastline) up to 20 km from the colony. Females rested less, foraged closer to the colony in more coastal waters, and showed a lower maximum flight speed than males. Males foraged more outside protected areas than females and showed higher variability in their foraging distribution throughout the tide cycle. As such, our study provides evidence for sex-specific aspects of foraging behaviour in common terns and underlines the importance of considering sex-specific foraging distributions when assessing the impact of at-sea threats on seabirds, knowledge of which should be incorporated when developing conservation management strategies.
Non-big Ulrich bundles: the classification on quadrics and the case of small numerical dimension
Authors: Lopez Angelo Felice , Muñoz Roberto , Sierra José Carlos 
Published: September 2023

AbstractOn any smooth n-dimensional variety we give a pretty precise picture of rank r Ulrich vector bundles with numerical dimension at most $$\frac{n}{2}+r-1$$

n
2

+
r
-
1

. Also, we classify non-big Ulrich vector bundles on quadrics and on the Del Pezzo fourfold of degree 6.
MIL-CELL: a tool for multi-scale simulation of yeast replication and prion transmission
Authors: Hall Damien 
Published: September 2023

AbstractThe single-celled baker’s yeast, Saccharomyces cerevisiae, can sustain a number of amyloid-based prions, the three most prominent examples being [URE3], [PSI+], and [PIN+]. In the laboratory, haploid S. cerevisiae cells of a single mating type can acquire an amyloid prion in one of two ways (i) spontaneous nucleation of the prion within the yeast cell, and (ii) receipt via mother-to-daughter transmission during the cell division cycle. Similarly, prions can be lost due to (i) dissolution of the prion amyloid by its breakage into non-amyloid monomeric units, or (ii) preferential donation/retention of prions between the mother and daughter during cell division. Here we present a computational tool (Monitoring Induction and Loss of prions in Cells; MIL-CELL) for modelling these four general processes using a multiscale approach describing both spatial and kinetic aspects of the yeast life cycle and the amyloid-prion behavior. We describe the workings of the model, assumptions upon which it is based and some interesting simulation results pertaining to the wave-like spread of the epigenetic prion elements through the yeast population. MIL-CELL is provided as a stand-alone GUI executable program for free download with the paper. MIL-CELL is equipped with a relational database allowing all simulated properties to be searched, collated and graphed. Its ability to incorporate variation in heritable properties means MIL-CELL is also capable of simulating loss of the isogenic nature of a cell population over time. The capability to monitor both chronological and reproductive age also makes MIL-CELL potentially useful in studies of cell aging.
Eastern Australian Farmers Managing and Thinking Differently: Innovative Adaptation Cycles
Authors: McKenzie David K. , Joyce Janine , Zander Kerstin K. , Wurm Penelope A. S. , Caudwell Kim M. 
Published: September 2023

AbstractThe uncertainty of climate change is a significant challenge prompting Australian farmers to create different thinking and different management systems that ensure sustained farm business viability and continuity, particularly in extreme environments. The purpose of this study was to explore the conditions and adaptive processes for managing farm resilience and cyclic adaptation pathways, in response to climate change. A positive deviance sample of farmers was interviewed, and data was collected from a cohort of twenty-two climate change innovators across Eastern Australia. Grounded theory analysis of data identified three processes and two transactional maps of climate change adaptation, in this under studied farmer cohort. The development of the transactional maps found the resilience and preparedness processes as adaptive learning responses to the stressors of climate change. The processes of managing the business and resources were identified as markers of preparedness and resilience that ensured business viability and continuity. Farmers prepared for climate change through transforming make-over processes as an adaptive learning response to climate challenges. Mapping the cycle of adaptation identified the processes of socio-cognitive agency, learning from feedback and consequences, and contextual variables as critical elements of adaptation. The intervening socio-ecological processes of intelligence gathering and influencing, and socio-cognitive precursors, were found to regulate the adaptation cycle. The cycle was found to have both incremental and transformative transmission processes, and intervening processes of climate and contextual variables. The changing patterns and extremes of climate change were found to impact the growing season, and its potential, as unique variables that demand farm adaptation. Ultimately, this study identified potential points of influence for leveraging preparedness behaviours.
Risk factors for thromboembolic events in patients with paroxysmal nocturnal hemoglobinuria (PNH): a nested case–control study in the International PNH Registry
Authors: Höchsmann Britta , Peffault de Latour Regis , Hill Anita , Röth Alexander , Devos Timothy , Patriquin Christopher J. , Chou Wen-Chien , Jain Deepak , Zu Ke , Wu Chuntao , Lee Jong Wook 
Published: September 2023

AbstractThe objective of this analysis was to identify risk factors for thromboembolic events (TE) in patients with paroxysmal nocturnal hemoglobinuria (PNH) who were not treated with C5 inhibitors. Patients with PNH and a history of ≥ 1 TE at enrollment in the International PNH Registry (NCT01374360; registration date, January 2011) were each matched with up to 5 patients without TE. Multivariable analysis was performed with the following variables: percentage glycosylphosphatidylinositol (GPI)–negative cells, high disease activity (HDA), non-TE major adverse vascular event history, and recent anticoagulation. Of 2541 eligible patients, 57 with TE and 189 matched controls were analyzed. Multivariable analysis (odds ratio [95% CI]) identified the following factors as being associated with increased thrombotic risk: patients with no history of TE (with recent anticoagulation, 9.30 [1.20–72.27]), patients with history of TE (with recent anticoagulation, 8.91 [0.86–92.62]; without recent anticoagulation, 5.33 [0.26–109.57]), patients with ≥ 30% GPI-negative granulocytes (≥ 30% to < 50%, 4.94 [0.54–45.32]; ≥ 50%, 1.97 [0.45–8.55]), or patients with lactate dehydrogenase (LDH) ratio ≥ 1.5 × upper limit of normal (ULN) plus ≥ 2 HDA criteria (2–3 criteria, 3.18 [0.44–23.20]; ≥ 4 criteria, 3.60 [0.38–33.95]). History of TE, ≥ 30% GPI-negative granulocytes, and LDH ratio ≥ 1.5 × ULN with ≥ 2 HDA criteria are TE risk factors for patients with PNH. These findings will aid physicians by providing important clinical and laboratory risk factors that can be used to identify and manage patients with PNH who are at risk of developing TE.
Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae
Authors: Rass Verena , Tymoszuk Piotr , Sahanic Sabina , Heim Beatrice , Ausserhofer Dietmar , Lindner Anna , Kofler Mario , Mahlknecht Philipp , Boehm Anna , Hüfner Katharina , Pizzini Alex , Sonnweber Thomas , Kurz Katharina , Pfeifer Bernhard , Kiechl Stefan , Peball Marina , Kindl Philipp , Putnina Lauma , Fava Elena , Djamshidian Atbin , Huber Andreas , Wiedermann Christian J. , Sperner-Unterweger Barbara , Wöll Ewald , Beer Ronny , Schiefecker Alois Josef , Bellmann-Weiler Rosa , Bachler Herbert , Tancevski Ivan , Pfausler Bettina , Piccoliori Giuliano , Seppi Klaus , Weiss Günter , Löffler-Ragg Judith , Helbok Raimund 
Published: September 2023

Abstract
Purpose
Olfactory dysfunction (OD) commonly accompanies coronavirus disease 2019 (COVID-19). We investigated the kinetics of OD resolution following SARS-CoV-2 infection (wild-type and alpha variant) and its impact on quality of life, physical and mental health.

Methods
OD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, ≥ 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.

Results
Both in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort (41%) self-reported OD was frequent during acute COVID-19. Recovery from self-reported OD was slow (survey: median 28 days, observational cohort: 90 days). By clustering of the survey data, we identified a predominantly young, female, comorbidity-free group of convalescents with persistent OD and taste disorders (median recovery: 90 days) but low frequency of post-acute fatigue, respiratory or neurocognitive symptoms. This smell and taste disorder cluster was characterized by a high rating of physical performance, mental health, and quality of life as compared with convalescents affected by prolonged fatigue or neurocognitive complaints.

Conclusion
Our results underline the heterogeneity of post-acute COVID-19 sequelae calling for tailored management strategies. The persistent smell and taste disorder phenotype is characterized by good clinical, physical, and mental recovery and may pose a minor challenge for public health.

Study registration
ClinicalTrials.gov: NCT04661462 (survey study), NCT04416100 (observational cohort).
Linking connectivity of deep brain stimulation of nucleus accumbens area with clinical depression improvements: a retrospective longitudinal case series
Authors: Leserri Simona , Segura-Amil Alba , Nowacki Andreas , Debove Ines , Petermann Katrin , Schäppi Lea , Preti Maria Giulia , Van De Ville Dimitri , Pollo Claudio , Walther Sebastian , Nguyen T. A. Khoa 
Published: September 2023

AbstractTreatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation’s therapeutic effect may be explained through the functional and structural connectivities between the stimulated area and other brain regions, or to depression-associated networks. In this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center. We analyzed the structural and functional connectivity of the stimulation area: the structural connectivity was investigated with probabilistic tractography; the functional connectivity was estimated by combining patient-specific stimulation volumes and a normative functional connectome. These structural and functional connectivity profiles were then related to four clinical outcome scores. At 1-year follow-up, the remission rate was 66%. We observed a consistent structural connectivity to Brodmann area 25 in the patient with the longest remission phase. The functional connectivity analysis resulted in patient-specific R-maps describing brain areas significantly correlated with symptom improvement in this patient, notably the prefrontal cortex. But the connectivity analysis was mixed across patients, calling for confirmation in a larger cohort and over longer time periods.
Healthcare utilization prior to a diagnosis of young-onset Alzheimer’s disease: a nationwide nested case–control study
Authors: Damsgaard Line , Janbek Janet , Laursen Thomas Munk , Waldemar Gunhild , Jensen-Dahm Christina 
Published: September 2023

Abstract
Objective
Our aim was to identify changes in healthcare utilization prior to a young-onset Alzheimer’s disease diagnosis.

Methods
In a retrospective incidence density matched nested case–control study using national health registers, we examined healthcare utilization for those diagnosed with young-onset Alzheimer’s disease in Danish memory clinics during 2016–2018 compared with age- and sex-matched controls. Negative binomial regression analysis produced contact rate ratios.

Results
The study included 1082 young-onset Alzheimer’s disease patients and 3246 controls. In the year preceding diagnosis, we found increased contact rate ratios for all types of contacts except physiotherapy. Contact rate ratios for contacts with a general practitioner were significantly increased also > 1–5 and > 5–10 years before diagnosis. The highest contact rate ratios were for psychiatric emergency contacts (8.69, 95% CI 4.29–17.62) ≤ 1 year before diagnosis.

Interpretation
Results demonstrate that young-onset Alzheimer’s disease patients have increased healthcare utilization from 5 to 10 years prior to diagnosis. Awareness of specific alterations in health-seeking behaviour may help healthcare professionals provide timely diagnoses.
Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment—detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations
Authors: Brambs Christine E. , Horn Lars-Christian , Hiller Ruth , Krücken Irene , Braun Christian , Christmann Corina , Monecke Astrid , Höhn Anne Kathrin 
Published: September 2023

Abstract
Purpose
Mesonephric-like adenocarcinomas (MLA) of the female genital tract represent a rare and relatively recently described neoplasm exhibiting characteristic morphologic and immunohistochemical findings commonly associated with a KRAS-mutation. Most cases display an aggressive clinical behavior, but knowledge about treatment approaches is limited, especially for targeting KRAS.

Methods
We report a series of eight cases with a detailed molecular analysis for KRAS. These cases as well as the data of previously published cases with detailed information regarding KRAS-mutational events were reviewed for a potential targeted approach and its prognostic impact.

Results
Both the uterine and ovarian MLA harbor a somatic KRAS-mutation in about 85% of the reported cases, affecting the hotspot codons 12 and 13. 15.7% of the endometrial and 15.6% of ovarian MLA are wild type for KRAS. A p.G12A-alteration was seen in 5.6% (5/89) of the endometrial and in 6.2% (2/32) of the ovarian tumors, for p.G12C in 7.9% and 6.2%, for p.G12D in 32.6% and 34.5% and for p.G12V in 36% and 37.5%, respectively. Very limited data are available regarding the prognostic impact of different mutational sites within the KRAS-gene without significant prognostic impact.

Conclusion
Because of a specific p.G12C-KRAS somatic mutation, only the minority of MLA (7.9% with uterine and 6.2% with ovarian primary) are potentially targetable by sotarasib in that rare but aggressive subtype of adenocarcinoma of the female genital tract. Until now, the different location of a somatic KRAS-mutation is of no prognostic impact.