bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral video-assisted thoracic surgery for esophageal cancer with left inferior pulmonary vein invasion following chemoradiation therapy
Authors: Fujii Masakazu , Okada Naoya , Kato Hiroaki , Ishihara Satoshi , Abe Masaru , Yamabuki Takumi , Kato Kentaro , Takada Minoru , Ambo Yoshiyasu , Yokoyama Takeshi , Kinoshita Yoshihiro 
Published: July 2023

Abstract
Background
The surgical strategy for thoracic esophageal cancer that invades the lungs is controversial. In particular, invasion of the pulmonary vein is often regarded unresectable. We successfully applied bilateral video-assisted thoracic surgery (VATS) in esophagectomy for esophageal cancer with left inferior pulmonary vein invasion following induction chemoradiotherapy (CRT), with a favorable response.

Case presentation
A 64-year-old woman was diagnosed with squamous cell carcinoma of the lower third of the esophagus. Computed tomography (CT) revealed that the tumor was suspected to be invading the main trunk of the left lower pulmonary vein and left lower lung. We initiated induction CRT comprising 5-fluorouracil, cisplatin, and concurrent radiotherapy at 50.4 Gy/28Fr. CT revealed shrinkage of the tumor, and the main trunk of the left inferior pulmonary vein was released from the tumor invasion. We considered the tumor to be completely resectable. VATS esophagectomy is usually performed using a right-sided approach. However, the right-sided approach is inappropriate for evaluating tumors around the left inferior pulmonary vein. We started with left-sided VATS to determine tumor resectability and dissected between the esophagus and the main trunk of the left inferior pulmonary vein. We only needed to perform partial resection of the left lower lobe. We then performed a right-sided VATS esophagectomy and lymphadenectomy with partial en bloc resection of the left lower lobe. Following this, we performed hand-assisted laparoscopic proximal gastrectomy and reconstruction using the gastric remnant. The postoperative course was uneventful. The patient was discharged on postoperative day 14. Histopathological examination of the surgical specimen revealed a complete pathological response without any remnant tumor or lymph node metastasis. There were no signs of recurrence or metastasis at the 1-year follow-up.

Conclusions
Curative resection for thoracic esophageal cancer that invades the pulmonary vein could be possible via the bilateral VATS approach following induction CRT with a favorable response.
Immediate and Delayed Effects of Joint Loading Activities on Knee and Hip Cartilage: A Systematic Review and Meta-analysis
Authors: Coburn Sally L. , Crossley Kay M. , Kemp Joanne L. , Warden Stuart J. , West Tom J. , Bruder Andrea M. , Mentiplay Benjamin F. , Culvenor Adam G. 
Published: July 2023

Abstract
Background
The impact of activity-related joint loading on cartilage is not clear. Abnormal loading is considered to be a mechanical driver of osteoarthritis (OA), yet moderate amounts of physical activity and rehabilitation exercise can have positive effects on articular cartilage. Our aim was to investigate the immediate effects of joint loading activities on knee and hip cartilage in healthy adults, as assessed using magnetic resonance imaging. We also investigated delayed effects of activities on healthy cartilage and the effects of activities on cartilage in adults with, or at risk of, OA. We explored the association of sex, age and loading duration with cartilage changes.

Methods
A systematic review of six databases identified studies assessing change in adult hip and knee cartilage using MRI within 48 h before and after application of a joint loading intervention/activity. Studies included adults with healthy cartilage or those with, or at risk of, OA. Joint loading activities included walking, hopping, cycling, weightbearing knee bends and simulated standing within the scanner. Risk of bias was assessed using the Newcastle–Ottawa Scale. Random-effects meta-analysis estimated the percentage change in compartment-specific cartilage thickness or volume and composition (T2 relaxation time) outcomes. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system evaluated certainty of evidence.

Results
Forty studies of 653 participants were included after screening 5159 retrieved studies. Knee cartilage thickness or volume decreased immediately following all loading activities investigating healthy adults; however, GRADE assessment indicated very low certainty evidence. Patellar cartilage thickness and volume reduced 5.0% (95% CI 3.5, 6.4, I2 = 89.3%) after body weight knee bends, and tibial cartilage composition (T2 relaxation time) decreased 5.1% (95% CI 3.7, 6.5, I2 = 0.0%) after simulated standing within the scanner. Hip cartilage data were insufficient for pooling. Secondary outcomes synthesised narratively suggest knee cartilage recovers within 30 min of walking and 90 min of 100 knee bends. We found contrasting effects of simulated standing and walking in adults with, or at risk of, OA. An increase of 10 knee bend repetitions was associated with 2% greater reduction in patellar thickness or volume.

Conclusion
There is very low certainty evidence that minimal knee cartilage thickness and volume and composition (T2 relaxation time) reductions (0–5%) occur after weightbearing knee bends, simulated standing, walking, hopping/jumping and cycling, and the impact of knee bends may be dose dependent. Our findings provide a framework of cartilage responses to loading in healthy adults which may have utility for clinicians when designing and prescribing rehabilitation programs and providing exercise advice.
Open source board based acoustofluidic transwells for reversible disruption of the blood–brain barrier for therapeutic delivery
Authors: Wang Ke , Sun Chao , Dumčius Povilas , Zhang Hongxin , Liao Hanlin , Wu Zhenlin , Tian Liangfei , Peng Wang , Fu Yongqing , Wei Jun , Cai Meng , Zhong Yi , Li Xiaoyu , Yang Xin , Cui Min 
Published: July 2023

Abstract

Background
Blood–brain barrier (BBB) is a crucial but dynamic structure that functions as a gatekeeper for the central nervous system (CNS). Managing sufficient substances across the BBB is a major challenge, especially in the development of therapeutics for CNS disorders.

Methods
To achieve an efficient, fast and safe strategy for BBB opening, an acoustofluidic transwell (AFT) was developed for reversible disruption of the BBB. The proposed AFT was consisted of a transwell insert where the BBB model was established, and a surface acoustic wave (SAW) transducer realized using open-source electronics based on printed circuit board techniques.

Results
In the AFT device, the SAW produced acousto-mechanical stimulations to the BBB model resulting in decreased transendothelial electrical resistance in a dose dependent manner, indicating the disruption of the BBB. Moreover, SAW stimulation enhanced transendothelial permeability to sodium fluorescein and FITC-dextran with various molecular weight in the AFT device. Further study indicated BBB opening was mainly attributed to the apparent stretching of intercellular spaces. An in vivo study using a zebrafish model demonstrated SAW exposure promoted penetration of sodium fluorescein to the CNS.

Conclusions
In summary, AFT effectively disrupts the BBB under the SAW stimulation, which is promising as a new drug delivery methodology for neurodegenerative diseases.

Graphical Abstract
Anopheles mosquito diversity, entomological indicators of malaria transmission and challenges of morphological identification in southwestern Ethiopia
Authors: Assa Adilo , Eligo Nigatu , Massebo Fekadu 
Published: July 2023

Abstract
Background
A number of Anopheles species play either a primary or secondary role in malaria transmission. This necessitates understanding the species composition, bionomics, and behaviors of malaria mosquitoes in a particular geographic area, which is relevant to design and implement tailored intervention tools. This study aimed to assess the species composition, sporozoite infection rate, and blood meal origins of malaria mosquitoes in two malaria-endemic villages of Boreda district in Gamo Zone, southwest Ethiopia.

Methods
Thirty houses, 20 for Center for Disease Control and Prevention (CDC) light traps and 10 for Pyrethrum Spray Catches (PSC) were randomly selected for bimonthly mosquito collection from October 2019 to February 2020. An enzyme-linked immunosorbent assay (ELISA) was carried out to detect the blood meal origins and circumsporozoite proteins (CSPs). The entomological inoculation rate (EIR) was calculated by multiplying the sporozoite and human biting rates from PSCs. Anopheles gambiae complex and An. funestus group samples were further identified to species by the polymerase chain reaction (PCR). Anopheles species with some morphological similarity with An. gambiae complex or An. funestus group were tested using the primers of the two species complexes.

Results
A total of 14 Anopheles species were documented, of which An. demeilloni was found to be the dominant species. An. arabiensis was found to be positive for P. falciparum CSP with the overall CSP rate of 0.53% (1/190: 95% CI 0.01–2.9). The overall estimated P. falciparum EIR of An. arabiensis from PSC was 1.5 infectious bites/person/5 months. Of the 145 freshly fed Anopheles mosquitoes tested for blood meal sources, 57.9% (84/145) had bovine blood meal, 15.2% (22/145) had human blood meal origin alone, and 16.5% (24/145) had a mixed blood meal origin of human and bovine. Anopheles demeilloni were more likely to feed on blood meals of bovine origin (102/126 = 80.9%), while An. arabiensis were more likely to have blood meals of human origin. Eleven samples (2.6%; 11/420) were morphologically categorized as An. demeilloni, but it has been identified as An. leesoni (the only An. funestus group identified in the area) by PCR, though it requires additional verification by sequencing, because different species genes may have amplified for these species specific primers. Similarly, a small number of An. arabiensis were morphologically identified as An. salbaii, An. maculipalpis and An. fuscivenosus.

Conclusions and recommendations
In spite of the wide variety of Anopheles mosquito species, An. arabiensis dominates indoor malaria transmission, necessitating additional interventions targeting this species. In addition, increasing entomological knowledge may make morphological identification less difficult.
Evolving market-shaping strategies to boost access to essential medical products in developing countries with HIV self-testing as a case study
Authors: Yang Jian , Feng Xiangning , Zhou Shuduo , Zhang Li , Hu Yunxuan , Chen Ying , Zhang Zhenyu , Xu Ming 
Published: July 2023

AbstractThe COVID-19 pandemic has exacerbated health inequities among countries in the Global South with limited access to essential medical products, leading to a higher infection and mortality rate, especially among vulnerable populations. Despite tremendous progress in global health financing, the estimated annual financing gap in developing countries is projected to reach US$371 billion per year by 2030. Therefore, developing market-shaping strategies is of great importance in ensuring adequate supply, affordable prices, and equitable access to essential medical products in low-and middle-income countries. We propose a strategic and appropriate market-shaping intervention framework for governments, international organizations, and NGOs to maximize access to essential medical products in developing countries. In the health field, we believe that market shaping strategy could be defined as a set of purposeful activities that market forces may intervene with to advance the development, production, supply, and distribution of global goods for health, making essential medical products more affordable, accessible, innovative, sustainable and quality assured. We argue that when designing a market-shaping strategy, policy or decision-makers must take full advantage of the key drivers to keep the market dynamic, interactive, and constantly evolving to meet the unmet medical needs. In addition, different forms of market-shaping interventions are determined by objectives and specific issues to be addressed. More comprehensive market shaping strategies, including the strategic use of market expansion, market disruption, market maintenance, and market contraction alone or together, deserve to be explored and key stakeholders are also expected to join forces to make the intervention more efficient and productive.
Validation of NASH-CHECK: a novel patient-reported outcome measure for nonalcoholic steatohepatitis
Authors: Twiss James , Whalley Diane , Doward Lynda , Balp Maria-Magdalena , Brass Clifford A. , Cryer Donna , Sanyal Arun , Anstee Quentin M. 
Published: July 2023

Abstract
Background
Standardized measures for evaluating patients’ experiences with nonalcoholic steatohepatitis (NASH) and their perceived changes with treatment in clinical trials have been limited. To meet this need, a patient-reported outcome (PRO) measure, NASH-CHECK, was developed to evaluate symptoms and health-related quality of life for patients with NASH. The objective of this study was to conduct a quantitative evaluation of the psychometric properties of NASH-CHECK.

Methods
The study used data from a phase 2, randomized controlled trial of adult patients with NASH (NCT02855164). Analyses were conducted to determine the optimal scoring of NASH-CHECK and to evaluate reliability, construct validity, and ability to detect change in NASH-CHECK scale scores.

Results
Data were available for 253 patients with NASH (61% female; mean [standard deviation] age = 53 [12] years). Following initial item-level analyses, including correlations and exploratory factor analysis, three items were removed from the measure. Confirmatory factor analysis supported the formation of four multi-item scales (Cognitive Symptoms, Activity Limitations, Social Impact, and Emotional Impact) and five single-item scales (Abdominal Pain, Abdominal Bloating, Fatigue, Sleep, and Itchy Skin). Psychometric analyses of the final NASH-CHECK scales provided support for their internal reliability, test–retest reliability, construct validity, and ability to detect change.

Conclusion
The results support NASH-CHECK as a reliable, valid, and responsive measure to assess patients’ perspectives of symptoms and the health-related quality of life impact of NASH in clinical trials and in routine practice.
Postoperative throat discomfort and associated factors among surgical patients at Ethiopian Teaching Hospitals: cross-sectional study
Authors: Jisha Hunduma , Bekele Zenebe 
Published: July 2023

Abstract
Background
Throat pain and airway discomfort are the most commonly upsetting conditions for patients’ wellbeing after surgery. However, little is known about the problem and associated factors, especially in developing countries like Ethiopia. Therefore, this work determined the magnitude, severity, and associated factors of throat discomfort within 24 h after elective surgery.

Results
The majority (63.2%, or 211) of the participants were female, with a mean age of 35.7 ± 9.7 years. The overall postoperative throat discomfort was observed in 122 (36.5%) patients, and it was severe in 20.5% of them. However, the severity level declined over time to 21.9% (21/96), 15.3% (18/118), and 5.6% (5/89), respectively, on the 1st, 6th, and 24th hours, as indicated by participants. Utilization of a larger ETT (AOR = 6.26, CI 2.13–18.43, P = 0.001), surgery lasting two or more hours (AOR = 11.20, CI 3.53–35.50, P = 0.000), awake extubation (AOR = 0.16, CI 0.05–0.43 P = 0.000), frequent episodes of hypotension (AOR = 12.85, CI 4.56–36.18, P = 0.000), and a less experienced anesthetist (AOR = 18.10, CI 6.51–50.31, P = 0.000) were significantly associated with throat discomfort.

Conclusions
Post-extubation throat discomfort complaints are high (36.5%). Due attention has to be given to minimize or prevent perioperative frequent episodes of hypotension, higher ETT size utilization, blood loss, and the duration of surgery as much as possible. Postoperative throat discomfort should not be ignored. And we recommend that patient reassurance and orientation with analgesia has to be considered during the postoperative period.
Stability evaluation of a grid-tied hybrid wind/PV farm joined with a hybrid energy-storage system
Authors: Wang Li , Ke Wang Jun-Yi , Wu Rui-Xuan , Tripathy Manoj , Mokhlis Hazlie , Chua Kein Huat , Prokhorov Anton V. , Nguyen Thi Ha , Farid Mohammed Mehdi , Subiantoro Alison , Li Kang , Chong Benjamin , Azizi Sadegh , Jahromi Amir Abiri , Xu Dehong 
Published: July 2023

AbstractThis paper presents the stability-evaluation outcomes of a multimachine power system (MMPS) connected with a large-scale hybrid wind farm (WF) and photovoltaic (PV) farm or hybrid wind/PV farm (HWPF) and a hybrid energy-storage system (HESS) consisting of a vanadium redox flow battery (VRFB) and a supercapacitor (SC). A probability scheme is used to determine the rated power of the proposed HESS, where the capacities of the VRFB-ESS and the SC-ESS are designed to effectively utilize their operating features. The control strategy of the HESS is proposed to reduce the pressure of the VRFB-ESS and smooth the output power fluctuations of the HWPF. The steady-state stability, small-signal stability, dynamic performances, and transient simulations of the studied grid-tied HWPF fed to the MMPS with and without the HESS are achieved. The simulation outcomes show that the proposed HESS can enhance the stability and power-smoothing performance of the HWPF fed to the MMPS.
Parotid pilomatricoma: a case presentation and literature review
Authors: Arioua Abdelilah , Youbi Anouar Benameur El , Ouattassi Naouar , Oudidi Abdellatif , Alami Mohamed Noureddine El Amine El 
Published: July 2023

Abstract
Background
Pilomatrixoma is a rare benign tumor of the hair follicle. It is more common in children and women. The cervical and facial region are the most frequent location for this type of tumor. Due to its variable clinical presentations, it can sometimes be misdiagnosed as a malignant tumor of surrounding tissues, as described in our case.
The diagnosis confirmation is pathological.

Case presentation
We report the case of a 34-year-old patient, who presented a swelling in the right parotid region gradually increasing in size for two years, with no facial asymmetry. Clinical examination revealed a rounded, well-defined mass, fixed to the superficial plan, without any cervical lymph nodes. The MRI showed a tumor that seems to be evolving from the superficial lobe of the right parotid, suggesting a pleomorphic adenoma. Total excision of the tumor without margins was performed, preserving the parotid tissue and the facial nerve. The postoperative course was normal; and the pathological study confirmed the diagnosis of pilomatrixoma.

Conclusion
Pilomatrixoma is a rare benign tumor but it remains a differential diagnosis of large tumors of the neck and parotid. It is mainly a pathological diagnosis, The treatment of choice still complete surgical excision.
RETRACTED AND REPLACED: Comparison of Cumulative Live Birth Rates Between Progestin and GnRH Analogues in Preimplantation Genetic Testing Cycles
Authors: Zhou Ruiqiong , Dong Mei , Huang Li , Wang Songlu , Wang Zhaoyi , Xu Liqing , Zhang Xiqian , Liu Fenghua 
Published: July 2023

Abstract
This article has been retracted and replaced. Please see this notice for details: https://doi.org/10.1210/clinem/dgae853.
Impact of Age on the Affective Responses Following Worksite Resistance Exercise in Career Firefighters
Authors: GERSTNER GENA R. , TRIVISONNO ABIGAIL J. , LAFFAN MEGAN R. , GIULIANI-DEWIG HAYDEN K. , MOTA JACOB A. , REGISTER-MIHALIK JOHNA K. , RYAN ERIC D. 
Published: July 2023

ABSTRACT

Introduction
The purpose of this study was to examine the impact of age on the affective responses (attitude, feelings, self-efficacy, intention, enjoyment, and fondness) after a worksite circuit-style resistance exercise routine in career firefighters.

Methods
Nineteen young (25.5 ± 3.3 yr) and 19 middle-aged male career firefighters (50.3 ± 3.5 yr) completed 2 d of physical testing at local fire stations. Participants were familiarized with the resistance training exercises (deadlift, shoulder press, lunge, and upright row) at visit 1 and performed a multirepetition maximum (RM) assessment to prescribe the appropriate loads for the resistance exercise bout on visit 2. The resistance training session included three sets of 8 to 10 repetitions per exercise at 80% 1-RM. Participants completed a postexercise questionnaire examining affective responses and a rating of perceived exertion (RPE). Mann–Whitney U tests and an independent t-test were used to determine differences between the young and middle-aged firefighters’ affective responses and RPE, respectively.

Results
There were no significant differences between groups for any of the six affective responses (P = 0.062–0.819) or RPE (P = 0.142).

Conclusions
Age did not influence the perceived effort or affective responses following an acute bout of worksite resistance exercise. Firefighters reported overall positive attitudes, feelings, and fondness paired with high self-efficacy and intention at a training frequency of twice per week. However, confidence, intention, and enjoyment decreased at higher training frequencies (i.e., 3–4x per week). Circuit-style resistance training performed twice per week may be a feasible and practical worksite exercise routine across ages in the fire service.
Is the Lung Built for Exercise? Advances and Unresolved Questions
Authors: PETERS CARLI M. , DEMPSEY JEROME A. , HOPKINS SUSAN R. , SHEEL A. WILLIAM 
Published: July 2023

ABSTRACT
Nearly 40 yr ago, Professor Dempsey delivered the 1985 ACSM Joseph B. Wolffe Memorial Lecture titled: “Is the lung built for exercise?” Since then, much experimental work has been directed at enhancing our understanding of the functional capacity of the respiratory system by applying complex methodologies to the study of exercise. This review summarizes a symposium entitled: “Revisiting ‘Is the lung built for exercise?’” presented at the 2022 American College of Sports Medicine annual meeting, highlighting the progress made in the last three-plus decades and acknowledging new research questions that have arisen. We have chosen to subdivide our topic into four areas of active study: (i) the adaptability of lung structure to exercise training, (ii) the utilization of airway imaging to better understand how airway anatomy relates to exercising lung mechanics, (iii) measurement techniques of pulmonary gas exchange and their importance, and (iv) the interactions of the respiratory and cardiovascular system during exercise. Each of the four sections highlights gaps in our knowledge of the exercising lung. Addressing these areas that would benefit from further study will help us comprehend the intricacies of the lung that allow it to meet and adapt to the acute and chronic demands of exercise in health, aging, and disease.