bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of the initial levels of calciprotein particles as a screening marker of mineral homeostasis in patients with cardiovascular disease and in patients with chronic kidney disease
Authors: Shishkova D. K. , Matveeva V. G. , Markova V. E. , Khryachkova O. N. , Indukaeva E. V. , Shabaev А. R. , Frolov A. V. , Kutikhin A. G. 
Published: January 2023

Aim. To evaluate the initial concentration of calciprotein particles (CPPs), which are scavengers of excessive calcium and phosphate, in patients with cardiovascular disease and in patients with chronic kidney disease as compared with the healthy volunteers.Material and methods. The study included 308 individuals as follows: 1) 88 participants of the PURE study without hemodynamically relevant carotid athero scle rosis and symptomatic coronary atherosclerosis; 2) 88 patients with cere brovascular disease (CVD) who required carotid endarterectomy; 3) 88 pa tients with coronary artery disease (CAD) who required percutaneous coronary intervention or coronary artery bypass graft surgery; 4) 63 patients with stage 5 chronic kidney disease (CKD). We measured following mineral homeostasis parameters: total and ionized calcium, phosphate, total protein, albumin, and fetuin-A. Then, we determined a baseline serum CPP concentration by flow cytometry using a fluorescent-labeled bisphosphonate OsteoSense 680EX. Results. In comparison with other patients, healthy volunteers had the highest serum CPP concentration (249 CPPs/µL), indicating the retained ability to compensate mineral homeostasis disturbances by aggregation of excessive calcium and pho sphate with acidic proteins (mineral chaperones). Reduced serum CPP concentration in patients with CVD (170 CPPs/µL), CAD (139 CPPs/µL), and stage 5 CKD (193-203 CPPs/µL) showed impaired aggregation of excessive serum calcium and phosphate, which was also reflected by an increased level of blood ionized calcium.Conclusion. Patients with CVD, CAD, and stage 5 CKD have lower serum CPP concentration than healthy individuals. In combination with elevated ionized calcium and reduced albumin, this suggests the depletion of calcium binding buffers in the serum of patients with cardiovascular and renal diseases.
Role of glycemic control in elective percutaneous coronary interventions in patients with type 2 diabetes
Authors: Karetnikova V. N. , Kchorlampenko A. A. , Osokina A. V. , Kochergina A. M. , Polikutina O. M. , Golubovskaia D. P. , Oleinik I. R. , Barbarash O. L. 
Published: January 2023

Aim. To assess the association of glycemic control (achievement of an individual target glycated hemoglobin level) with the outcomes of elective percutaneous coronary interventions in patients with type 2 diabetes (T2D).Material and methods.This cohort observational study included 74 patients with a median age of 61 (57; 64) years. There were 49% of men with a previously established T2D, who had indications for elective primary percutaneous coronary intervention (PCI) for stable coronary artery disease. At inclusion in the study and after 1 month, the concentration of fasting blood glucose, glycated hemoglobin (HbA1c), fructosamine, and serum creatinine were determined. Plasma glucose levels were determined using the hexokinase method. HbA1clevel was determined by immunoturbidimetry on a Konelab 30i chemistry analyzer. The concentration of fructosamine was determined by the kinetic colorimetric assay on a Konelab 30i chemistry analyzer. Statistical processing was carried out using the Statistica 10.0 program from StatSoft, Inc. (USA).Results.At the time of enrollment, 31% of participants had not achieved the target glycated hemoglobin level against the background of nonoptimal hypoglycemic therapy in most cases. A total of 18 (25%) following adverse cardiovascular events were registered within 12 months after PCI: 11 (15%) patients developed acute coronary syndrome; among them, 6 (8%) patients had stent restenosis according to coronary angiography, 4 (6%) patients — progression of atherosclerosis, which required repeated PCI with stenting of another vessel, 2 (3%) patients — cerebrovascular accident, and 3 (4%) patients were hospitalized due to de compensated heart failure. According to multivariate logistic regression, only the HbA1clevel was a predictor of adverse outcomes during the year after PCI — a 1% increase in HbA1clevel increased the risk of adverse outcomes by 1,79 times (odds ratio, 1,79, 95% confidence interval, 1,06-3,02, p=0,028). Poor glycemic control 1 month before PCI increased the risk of cardiovascular events by 4,04 times over the next year, while non-target HbA1clevel immediately before PCI increased the risk of adverse outcomes by 4,7 times, and 5 months after PCI, by 7,34 times.Conclusion.The significance of non-target glycated hemoglobin level for adverse outcomes during the year after elective PCI against the background of T2D was established with an increase in the negative effect as long-term (after myocardial revascularization) maintenance of poor glycemic control.
2016 HOLLANDA-TÜRKİYE SİYASİ KRİZİNE HÜRRİYET VE HOLLANDA BASINININ ÖNEMLİ GAZETESİ ALGEMEEN DAGBLAD’IN BAKIŞININ KARŞILAŞTIRILMASI
Authors: FERİDUNOĞLU İsmail Cem 
Published: January 2023

Haber, artık günümüzde hemen herkesi ilgilendiren bir
kavramdır. Medya ise bu anlamda önemli bir söylem oluşturma alanıdır. Medyanın
görevi, haber söyleminin içinde yer alan olaylar ve gerçekleri sözde yaratarak,
canlandırmaktadır. Böylece söylem, kaynak ve hedef arasında kurulan bir
diyalogdur. Medya, herhangi bir eylem ya da söyleme nereden bakıldığının ortaya
konulması açısından önemlidir. Zira medya siyasi ve sosyal olayların
yorumlanarak insanların zihnine yerleşmesinde birincil derecede etkilidir. Mart
2017’de yaşanan Hollanda-Türkiye krizinde de basının bakış açısı oldukça
önemlidir. 21 Ocak tarihinde TBMM tarafından kabul edilen ve 16 Nisan’da
halkoyuna sunulacak olan Anayasa değişikliği çerçevesinde Türk Bakanların Avrupa’da
yaşayan vatandaşlara yönelik mitingler düzenlemek istemeleri ve bu mitinglerin
ilk olarak Almanya’da daha sonra da Hollanda’da iptal edilmesi krizin başlangıç
noktasını oluşturmuştur. Almanya ile başlayan sorun, 15 Mart 2017 yapılacak
genel seçiminin arifesinde olan Hollanda ile derinleşmiş ve karşılıklı
suçlayıcı açıklamalarla diplomatik kriz boyutuna gelmiştir.

İlk olarak 2 Mart günü Adalet Bakanı Bekir Bozdağ’ın
Almanya’nın Gaggenau şehrinde ve Ekonomi Bakanı Nihat Zeybekçi’nin de Köln’de
yapacağı konuşmalara yasak getirilmiştir. Bunun ardından karşılıklı sert
söylemler sonucu, iki ülke arasındaki gerilim tırmanmıştır.

Bu bağlamda Türk
Medyası’ndan Hürriyet Gazetesi ile Hollanda Basını’ndan Algemeen Dagblad
gazeteleri incelenmiş, kriz olgusu medya aracılığıyla değerlendirilmiştir.
Çalışmada yöntem olarak içerik ve söylem analizi uygulanmıştır.
ТУРКИ АХЫСКА - ТРИЖДЫ ДЕПОРТИРОВАННЫЙ НАРОД
Authors: DERVİŞ Leyla 
Published: January 2023

В статье кратко рассмотрена история малой народности – турок
ахыска. Сделаны выводы относительно генезиса этой народности, ареала ее
исторического расселения. Подчеркиваются сложные условия становления и
исторического развития ахыска, обусловленные дискриминационной политикой по
отношению к ним, в первую очередь, со стороны российского и советских
правительств. Данная политика имела явную тенденцию к своему
ужесточению – так, если в период Российской империи в отношении турок ахыска
применялись исключительно дискриминационные меры, связанные с ограничением их
гражданско-правового статуса, то в период существования советской власти именно
депортация как одна из крайних форм
дискриминации в отношении этнического меньшинства стала основным политическим
методом. Вместе с этим распад советской государственности еще более осложнил
жизнидеятельность ахыскитнцев. Так, в Узбекистане они стали объектами
политических репрессий и этнических чисток, в Армении в результате эскалации
нагорно-карабахского конфликта стали беженцами, в России подвергались
дискриминации со стороны властей и казаческого сообщества, поскольку осели на
территории Краснодарского и Ставропольского краев. На протяжении 1990- х гг. в
этих регионах стали происходить частые погромы на этнической почве. В настоящее
время ахыскинцы все также далеки от разрешения проблем национальной
консолидации и возвращения на Родину.

В статье характеризуются отдельные этапы дискриминационной
политики, основные «волны» осуществления депортаций ахыска, в связи с чем формулируется
вывод о том, что именно на правительство Российской Федерации следует возлагать
ответственность за осуществление репатриации ахыскинцев в места их желаемого проживания. Определяется наиболее
реальное направление репатриации турков ахыска, а именно Турецкая Республика.
Yoga and Couple Relationship Satisfaction: The Synergy Between Mindfulness and Emotional Intelligence
Authors: Galloway Nadine , Foulstone Alexis , Lurie Janine 
Published: January 2023

Abstract
Couple relationship satisfaction is an important predictor of physical and mental health. Despite this, currently offered interventions for distressed couples are not always effective. The present cross-sectional online survey design examined how yoga practice, mindfulness, and emotional intelligence interrelate when predicting relationship satisfaction. The study consisted of 128 heterosexual married or cohabiting Australian adults (mean age 29.7 ± 9.3) who practice yoga. Supporting the hypothesis, a serial mediation analysis revealed that time spent practicing yoga had a positive influence on relationship satisfaction through mindfulness, and then through emotional intelligence (b = 0.005, 95% CI 0.001 to 0.009). The findings also showed a direct effect of time spent practicing yoga on relationship satisfaction; however, there was no support for the individual mediating effects of mindfulness and emotional intelligence on the association between time spent practicing yoga and relationship satisfaction. The current findings suggest that yoga may be an effective and easily implemented approach to improving mindfulness and enhancing emotional intelligence, as well as heterosexual couples’ relationship satisfaction.
Methodology for strategic management of the digital potential of complex economic systems based on the platform concept
Authors: Glukhov V. V. , Babkin A. V. , Shkarupeta E. V. , Gileva T. A. , Pletnev D. A. 
Published: January 2023

Purpose: the purpose of this article is to form a holistic methodology of digital platform strategizing, based on the methods, rules and postulates of strategic management of complex economic systems using different types of platforms in order to increase the digital potential.Methods: the authors used general scientific methods – the method of synthesis, generalization, content analysis, graphical interpretation of data. During the study, we used a six-step method, as well as the standardized methodology of the independent systematic review of the literature on the basis of the eight-step manual.Results: the author's vision of the methodology of strategic management of the digital potential of economic systems as a multi-level cognitive continuum, which allows to describe the full range of theoretical and practical perspectives of the application of methods, rules and postulates of management of the digital potential of economic systems, has been developed. Six architectural levels of the methodology of strategic management of the digital potential of economic systems are identified. Each architectural level is represented by a set of corresponding patterns: the gnoseological level is based on digital philosophy and digital thinking; the paradigmatic level is represented by the coevolution of three approaches and conceptual domain of digital platform strategizing; the ontological level is represented by the terminological apparatus; the semantic level is represented by the framework of digital platform strategizing and the platform concept; the technological level is represented by strategies of economic systems transformation into bionic, business models of digital strategy and digital behavior patterns; the applied level is represented by the methods for assessing the digital maturity and digital gaps of industrial systems.Conclusions and Relevance: the digital development of complex economic systems entails their transformation into bionic and inverted organizations based on an interdisciplinary platform concept, digital strategizing, digital philosophy, digital thinking, digital technologies and Industry 5.0 solutions, driven by the need to increase digital maturity, develop digital capabilities to maintain existing and/or create additional long-term competitive advantages.
Transformation of approaches of investment policy in the field of implementation of infrastructure projects in South Africa
Authors: Makarova A. A. 
Published: January 2023

Purpose: to study the current state and approaches of South Africa to the transformation of investment policy in the field of infrastructure projects in order to identify the results achieved and the prospects for ongoing reforms.Methods: general scientific methods were used in the study, in particular the analysis of statistics, the methods of deduction, analysis and synthesis. The sample of scientific studies and analytical materials on which the study is based draws on the work of scientists and experts on the topic in the region under study.Results: the assessment of the current state of the infrastructure sector of South Africa was carried out. The reasons for the need for reforms in the field of investment policy in order to stimulate the development of infrastructure in general and the implementation of infrastructure projects in particular were clarified, key directions for its transformation were identified. The tools being introduced were described and visually presented. An assessment of the results achieved to date was given.Conclusions and Relevance: the process of transformation of the investment policy of South Africa in the field of implementation of infrastructure projects is not yet complete. The achievement of all the goals set is hampered by both external factors, such as the consequences of the spread of the COVID-19 virus and others, and internal crises. Nevertheless, the attempts made by the state to increase the effectiveness of investment policy to improve the situation with infrastructure in the country have positive results. If the ongoing efforts are implemented to overcome the funding gap and solve problems associated with the low level of success of infrastructure projects, South Africa will not only be able to significantly improve the current situation in the infrastructure sector, but also significantly improve economic performance, which will undoubtedly have a positive impact on increasing the country's competitiveness.
Financial stability of local budgets in crisis periods: problems and solutions
Authors: Fedorova I. Yu. , Frygin A. V. 
Published: January 2023

Purpose: to assess the degree of growth of threats to the public sector, with an emphasis on their impact on the financial stability of local budgets, to consider the feasibility of using a set of budgetary and financial instruments by municipal authorities to counteract budgetary risks growing in crisis conditions.Methods: the study is based on the use of a systematic approach, general scientific methods, including analysis, synthesis, comparison, as well as the use of methods of economic and statistical analysis and processing of analytical data, analogies and scientific generalizations, a tabular way of visualizing research results.Results: the analysis and assessment of the factors of influence made it possible to substantiate the expediency of using by the budgets of the Moscow Region of a set of budgetary, financial, tax and other management tools that ensure an increase in the efficiency of budgetary impact on socio-economic processes during the period of crisis. Growing budget risks associated to a greater extent with the uncertainty and unforeseen economic situation and affecting the financial stability of local budgets are identified. The methodology for assessing the depth of the crisis state of budgets and determining the pace of a possible recovery of the economy of the municipal sector based on optimizing the indicators of budget revenues and expenditures, which helps to increasing financial stability, is proposed.Conclusions and Relevance: the approbation of the methodology for assessing the financial stability of local budgets in times of crisis has shown that administrations can more quickly and adequately respond to ongoing changes, find optimal, often non-standard ways to solve problems and reduce negative consequences, taking into account the fullest possible implementation of the functions provided for by the current legislature. The proposed approach creates an opportunity for building new systemic mechanisms for the interaction of municipal government bodies and other economic entities on a mutually beneficial basis. In the context of increasing budget tension, this enables the authorities to act proactively and quickly minimize threats to ensuring the sustainability of budgets, which is especially important for maintaining socio-economic territorial stability in this crisis period.
Methodology for assessing the development of regional production infrastructure (on the example of the Republic of Crimea)
Authors: Kirilchuk S. P. , Ergin S. M. , Nalivaychenko E. V. , Artuhova I. V. 
Published: January 2023

Purpose: is to present the author's methodology for assessing the regional production infrastructure, formed on the example of the Republic of Crimea, which allows identifying the drivers of its development to ensure the growth of the region's economy.Methods: the methodological basis of the study consists of: the method of factor analysis – to determine the driving factors of the justification of the drivers of economic growth; the method of regression analysis – to monitor the regional infrastructure of the Crimea; the method of system analysis – to study the spatial distribution of its regional infrastructure; correlation analysis and research analysis of spatial data – to carry out an expert assessment of the temporal and spatial characteristics of the regional production infrastructure of the region.Results: the article substantiates the dependence of the economic growth of the regional economy on various spatial and temporal factors of the regional production infrastructure. The authors propose a methodology for measuring the regional production infrastructure in the Crimea, including the selection and calculation of the parameters of its components, checking the closeness of the connection of these components, building a model for evaluating the effectiveness of regional production infrastructure, evaluating and analyzing integral indices of its level of development. As a result of the study, the main drivers of economic growth in the region were selected, namely, institutional and resource factors that will ensure the rational functioning of the economic mechanism in the Republic of Crimea, taking into account the work of economic entities in the context of digitalization.Conclusions and Relevance: the presented research allowed to substantiate the modern spatial structure of the development of regional infrastructure, the main characteristic of which is the uneven pace of development in the municipal territorial formations of the Republic of Crimea. Ranking of the identified driving forces of economic growth is valuable information in the implementation of infrastructure projects.
Physical Educators’ Exergaming Integration Experiences, Attitudes, and Self-Efficacy Beliefs
Authors: Krause Jennifer M. , Jenny Seth E. 
Published: January 2023

Exergaming technologies have emerged in physical education in recent years as an attempt at revitalizing physical activity levels among youth. Research on the effects of exergaming is increasing; however, there is no research on practicing physical education teachers’ implementation in the United States. Studies indicate that physical educators have low levels of confidence with regard to technology integration, particularly exergames. Due to exergaming technology’s potential impact, it is essential to understand the extent to which physical education teachers implement these technologies. Self-efficacy beliefs, influenced by prior experiences, are powerful motives of behavior. Thus, grounded in self-efficacy theory, this study investigated pedagogical exergaming experiences, attitudes, and self-efficacy beliefs of a nationwide sample of U.S. kindergarten through 12th-grade physical education teachers. Study participants included 402 in-service physical education teachers from 35 states who completed the online Physical Educators’ Exergaming Technology Integration, Attitudes, and Self-Efficacy Inventory. Participants reported moderate to high levels of attitude and self-efficacy beliefs, and Pearson correlation coefficients suggested strong, positive relationships between attitude and self-efficacy beliefs (r = .56, n = 402, p < .001) toward integrating exergaming technology in PE. Teachers’ prior exergaming integration into PE experiences was positive overall, yet limited because of barriers such as budget, equipment, training, and administrative support. Overall, results suggest that physical education teachers feel confident and have positive attitudes toward implementing exergaming in physical education, with self-efficacy regarding implementing exergaming in PE correlating strongest with prior successful mastery experience.
The context signals of mitochondrial miRNAs (mitomiRs) of mammals
Authors: Vishnevsky O. V. , Vorozheykin P. S. , Titov I. I. 
Published: January 2023

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level in the cytoplasm and play an important role in a wide range of biological processes. Recent studies have found that the miRNA sequences are presented not only in the cytoplasm, but also in the mitochondria. These miRNAs (the so-called mitomiRs) may be the sequences of nuclear or mitochondrial origin; some of them are involved in regulation of the mitochondrial gene functions, while the role of others is still unknown. The identification of nucleotide signals, which are unique to mitomiRs, may help to determine this role. We formed a dataset that combined the experimentally discovered mitomiRs in human, rat and mouse. To isolate signals that may be responsible for the mitomiRs’ functions or for their translocation from or into mitochondria a context analysis was carried out for the sequences. For three species in the group mitomiRs/non-mitomiRs and the group of all miRNAs from the miRBase database statistically overrepresented 8-letter motifs were identified (p-value < 0.01 with Bonferroni correction for multiple comparisons), for these motifs the patterns of the localization in functionally important regions for different types of miRNAs were found. Also, for the group mitomiRs/non-mitomiRs we found the statistically significant features of the miRNA nucleotide context near the Dicer and Drosha cleavage sites (Pearson’s χ2 test of independence for the first three positions of the miRNA, p-value < 0.05). The observed nucleotide frequencies may indicate a more homogeneous pri-miRNA cleavage by the Drosha complex during the formation of the 5’ end of mitomiRs. The obtained results can help to determine the role of the nucleotide signals in the origin, processing, and functions of the mitomiRs.