bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of digital voice biomarkers and associations with cognition, cerebrospinal biomarkers, and neural representation in early Alzheimer's disease
Authors: Hajjar Ihab , Okafor Maureen , Choi Jinho D. , Moore Elliot , Abrol Anees , Calhoun Vince D. , Goldstein Felicia C. 
Published: February 2023

AbstractIntroductionAdvances in natural language processing (NLP), speech recognition, and machine learning (ML) allow the exploration of linguistic and acoustic changes previously difficult to measure. We developed processes for deriving lexical‐semantic and acoustic measures as Alzheimer's disease (AD) digital voice biomarkers.MethodsWe collected connected speech, neuropsychological, neuroimaging, and cerebrospinal fluid (CSF) AD biomarker data from 92 cognitively unimpaired (40 Aβ+) and 114 impaired (63 Aβ+) participants. Acoustic and lexical‐semantic features were derived from audio recordings using ML approaches.ResultsLexical‐semantic (area under the curve [AUC] = 0.80) and acoustic (AUC = 0.77) scores demonstrated higher diagnostic performance for detecting MCI compared to Boston Naming Test (AUC = 0.66). Only lexical‐semantic scores detected amyloid‐β status (p= 0.0003). Acoustic scores associated with hippocampal volume (p= 0.017) while lexical‐semantic scores associated with CSF amyloid‐β (p= 0.007). Both measures were significantly associated with 2‐year disease progression.DiscussionThese preliminary findings suggest that derived digital biomarkers may identify cognitive impairment in preclinical and prodromal AD, and may predict disease progression.HighlightsThis study derived lexical‐semantic and acoustics features as Alzheimer's disease (AD) digital biomarkers.These features were derived from audio recordings using machine learning approaches.Voice biomarkers detected cognitive impairment and amyloid‐β status in early stages of AD.Voice biomarkers may predict Alzheimer's disease progression.These markers significantly mapped to functional connectivity in AD‐susceptible brain regions.
Retracted: The Effect of Air on the Oxidation Decomposition of Cationic Exchange Resins in a Ternary Li2CO3−Na2CO3−K2CO3 Molten‐Salt System
Authors: Zhang Zhi , Xue Yun , Yan Yongde , Ma Fuqiu , Li Guoqiang 
Published: February 2023

AbstractThe molten‐salt oxidation method (MSO) can be applied for disposal of spent cationic exchange resins (CERs) after the treatment of nuclear industry wastewater. In this work, the oxidation decomposition of resins in carbonate molten salt in N2 and air atmospheres was investigated. The SEM morphology and FTIR spectrograms indicated that the addition of air obviously prompted the oxidation decomposition of the benzene ring, S−O bond and S−C bond in residues and the decomposition efficiency of resins reached 98.69 % at 800 °C. The XPS analysis showed the conversion of sulfur species in residues. The peroxide and superoxide ions in carbonate molten salt prompted the decomposition of thiophene sulfur and resulted in the formation of sulfate. The retention rate of sulfur in spent salt was 84.36 % at 800 °C. This work provided more theoretical guidance for the treatment of resins and technical support for the sustainable development of nuclear industry.
Design and implementation of dynamic safety supervision system based on study tour for primary and secondary school students
Authors: Lin Weihua , Tu Yiwen , Liu Fujiang , Guo Yan , Zhou Ji , Feng Shixiang 
Published: February 2023

AbstractAt present, in the process of study tour, study tutors are responsible for supervising the safety of primary and secondary schools' students, and many hidden dangers are present in safety supervision. Therefore, how to provide study tutors with intelligent information tools and thus help safety tour have become the primary issue for the construction of research bases and the normal. For this reason, this study proposes an adaptive dynamic security area generation method and dynamic security area early warning technology. By comparing the location of the dynamic security area and the dangerous area, whether the users in the area are in a safe state can be determined. On the basis of mobile smart terminals, a dynamic safety supervision system that supports the study tour of primary and secondary school students has been developed. Practical application shows that the system has perfect functions and safe, stable, and reliable performance. The system has good application prospects and promotion value and can be used in other similar field safety management and control fields.
Synchronous heart rate reduction with suppression‐burst pattern in KCNT1‐related developmental and epileptic encephalopathies
Authors: Yamamoto Kaoru , Baba Shimpei , Saito Takashi , Nakagawa Eiji , Sugai Kenji , Iwasaki Masaki , Fujita Atsushi , Fukuda Hiromi , Mizuguchi Takeshi , Kato Mitsuhiro , Matsumoto Naomichi , Sasaki Masayuki 
Published: February 2023

AbstractSuppression‐burst (SB) is an electroencephalographic pattern observed in neonatal‐ and infantile‐onset developmental and epileptic encephalopathies (DEEs), which are associated with high mortality in early life. However, the relation of SB electroencephalogram (SB‐EEG) with autonomic function requires clarification. We investigated the relationship between heart rate (HR) and phasic transition during SB‐EEG in DEEs to explore the mechanism of early death. Seven patients (two with KCNT1‐DEE) with neonatal‐ and infantile‐onset DEE who presented with SB‐EEG were retrospectively identified. Five‐minute SB‐EEGs were analyzed with simultaneous recording of electrocardiograms. Mean HR, suppression duration, and burst period were calculated by measuring RR intervals. Two patients with KCNT1‐DEE exhibited synchronous HR fluctuations, with an HR decrease during suppression and an increase during burst. The HR decrease was larger (−6.1% and −7.7%) and the median duration of suppression was longer (4.0 and 8.2 s) in patients with KCNT1‐DEE than the other five (range: −2.9% to 0.9% and 0.7‐1.7s, respectively). A strong negative correlation was confirmed between suppression duration and HR reduction rates in one patient with KCNT1‐DEE. SB phases may influence HR regulation in patients with KCTN1‐DEE.
Design of an efficient energy management system for renewables based wireless electric vehicle charging station
Authors: Srividya K. S. , Hemavathi S. , Preetha Roselyn J. 
Published: February 2023

AbstractThe radical decline in climatic conditions coerces the world to take steps progressive toward implementing green energy technologies in all facets. The electric vehicle is one such huge leap toward providing a pollution‐free environment to the future generation, but the charging techniques in most cases utilize the power that is obtained using thermal power stations, and so on. This concludes it to be not completely green energy, therefore in this paper, considered two far‐reaching sources viz. photovoltaic and wind energy storage systems. The sources are also supported with the presence of an additional storage unit of battery energy storage system (BESS) and the overall system is managed by energy management system (EMS) that is designed using a simple state flow algorithm instead of complex machine learning methods. The electric vehicle (EV) is charged using wireless power transfer technology. The model is built using MATLAB—Simulink software and the simulation results are validated against the physical calculation carried out over the equivalent circuit model reduction method. The values were taken from the TATA Nexon EV for consideration and the output values are 400 V and 15 A to be provided for the charging of the EV at the receiving end of the wireless charging.
Nitric oxide treatment delays quality deterioration and enzymatic browning of Agaricus bisporus via reactive oxygen metabolism regulation
Authors: Gao Xiaoqian , Wu Weijie , Chen Huizhi , Niu Ben , Han Yanchao , Fang Xiangjun , Chen Hangjun , Liu Ruiling , Gao Haiyan 
Published: February 2023

AbstractNitric oxide (NO) is a highly reactive gaseous small molecule that regulates plant growth. Sodium nitroprusside (SNP) was used as an NO donor to study the effects of NO treatment on browning and antioxidant activity of button mushrooms (Agaricus bisporus). The findings revealed that exogenous NO treatment alleviated the browning, decreased hardness, and increased weight loss of mushrooms stored at 4°C for 15 days, and reduced the accumulation of reactive oxygen species and membrane lipid peroxidation. Moreover, exogenous NO treatment dramatically increased the anabolism of endogenous NO, maintained the content of antioxidant substances including flavonoids and total phenols, and kept catalase and superoxide dismutase activities at a high level. Further studies revealed that exogenous NO treatment inhibited the activities of enzymes that are involved in browning, which including polyphenol oxidase (PPO) and tyrosinase (TYR), and increased phenylalanine ammonia‐lyase (PAL) activity, with SNP treatment at 0.05 mM being the most effective. Furthermore, SNP treatment at 0.05 mM also inhibited PPO and TYR gene expressions while increasing PAL gene expression. Therefore, our findings suggest that exogenous NO has the potential for development in delaying postharvest browning and maintaining the quality of mushrooms.
A preliminary choroid plexus volumetric study in individuals with psychosis
Authors: Senay Olcay , Seethaler Magdalena , Makris Nikos , Yeterian Edward , Rushmore Jarrett , Cho Kang Ik K. , Rizzoni Elizabeth , Heller Carina , Pasternak Ofer , Szczepankiewicz Filip , Westin Carl‐Frederik , Losak Jan , Ustohal Libor , Tomandl Josef , Vojtisek Lubomir , Kudlicka Peter , Kikinis Zora , Holt Daphne , Lewandowski Kathryn E. , Lizano Paulo , Keshavan Matcheri S. , Öngür Dost , Kasparek Tomas , Breier Alan , Shenton Martha E. , Seitz‐Holland Johanna , Kubicki Marek 
Published: February 2023

AbstractThe choroid plexus (ChP) is part of the blood‐cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging‐based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.
Diagnostic potential of salivary interleukin‐17, RANKL, and OPG to differentiate between periodontal health and disease and discriminate stable and unstable periodontitis: A case‐control study
Authors: Abdullameer Marwa A. , Abdulkareem Ali A. 
Published: February 2023

AbstractBackground and AimsLimitations of the conventional diagnostic techniques urged researchers to seek novel methods to predict, diagnose, and monitor periodontal disease. Use of the biomarkers available in oral fluids could be a revolutionary surrogate for the manual probing/diagnostic radiograph. Several salivary biomarkers have the potential to accurately discriminate periodontal health and disease. This study aimed to determine the diagnostic sensitivity and specificity of salivary interleukin (IL)‐17, receptor activator of nuclear factor‐κB ligand (RANKL), osteoprotegerin (OPG), RANKL/OPG for differentiating (1) periodontal health from disease and (2) stable and unstable periodontitis.MethodsParticipants with periodontitis (n = 50) and gingivitis (n = 25), both diseases represented the cases, and subjects with healthy periodontium (n = 15) as a control were recruited for this study. Periodontitis cases were further equally subdivided into stable and unstable. Whole unstimulated salivary sample were collected from all participants. Periodontal parameters including bleeding on probing, probing pocket depth, clinical attachment loss, and number of missing teeth were recorded. The protein levels of salivary IL‐17, RANKL, and OPG were determined by using enzyme‐linked immunosorbent assays technique.ResultsSalivary IL‐17, OPG, RANKL, and RANKL/OPG showed high sensitivity and specificity to differentiate periodontal health from gingivitis and periodontitis. Similar pattern was observed in discriminating stable and unstable periodontitis. Salivary IL‐17 and RANKL showed a good accuracy to differentiate gingivitis from periodontitis. However, OPG and RANKL/OPG did not exhibit enough sensitivity and specificity to differentiate the latter conditions.ConclusionSalivary IL‐17, RANKL, OPG, and RANKL/OPG system are potential candidates for differentiating periodontal health and disease and discriminate stable and unstable periodontitis.
Identifying river water sources using end‐member mixing analysis in a subtropical monsoon basin China
Authors: Xiao Xiong , Zhang Xinping , Shi Xiaonan , Yu Zhengliang , Liu Keshao , Liu Zhu 
Published: February 2023

AbstractPressure on river water resources may increase continuously under global climate change and the increasing intensity of human activity, and the identification of river water sources is needed to maintain water resource sustainability. In this study, river water sources were studied using hydrochemical tracers (i.e. the major ions) and end‐member mixing analysis (EMMA) during two hydrological years, in the subtropical monsoon basin of the Xiangjiang River in the south‐central China. Various water types including precipitation, river water, and mountain creek water, were collected in the basin at a high frequency. The results of EMMA showed that the average contributions from the direct input of precipitation, near‐surface runoff (represented by mountain creek water), and groundwater (represented by river water sampled during the base flow period) were 28 ± 24%, 49 ± 24% and 23 ± 16%, respectively. The contributions from these water sources to the river water varied greatly within the year, which may indicate a shift in the major flow pathways from direct precipitation input and near‐surface flow pathways in the spring rainy months (e.g. from March to May), to a deeper flow pathway in the dry or rainless months (e.g. January, February, July and December). The shift of the major flow pathways may be due to the factors such as the seasonality of precipitation, evapotranspiration and soil wetness conditions. Groundwater and near‐subsurface runoff dominated the river water and the direct input of precipitation was negligible during the dry or rainless months, and consequently, the river water chemistry was less diluted and more influenced by water‐soil/rock interactions and anthropogenic pollution during these months. The creek water contribution to the river water was relatively high in summer, especially in June and July 2021, which may indicate the substantial inter‐seasonal carryover of precipitation that contributed to the river water. With the projected increased frequency of extreme weather events such as seasonal drought, streamflow in the subtropical monsoon regions may experience greater recharge by deeper flow pathways, with the enhanced role of base flow in regulating streamflow, and there may be an increased risk to the water resource security under the condition of the decreased river dilution capacity and increased anthropogenic pollution.
The effect of cognitive behavioural therapy integrated with activity pacing on cancer‐related fatigue, depression and quality of life among patients with breast cancer undergoing chemotherapy in Ethiopia: A randomised clinical trial
Authors: Getu Mikiyas Amare , Wang Panpan , Addissie Adamu , Seife Edom , Chen Changying , Kantelhardt Eva Johanna 
Published: February 2023

AbstractFatigue is a common symptom experienced by 80% of individuals who receive chemotherapy and is one of the major factors that affect quality of life (QoL) of patients with breast cancer. Our study aimed to assess the effect of cognitive behavioural therapy integrated with activity pacing (CBT‐AP) on cancer‐related fatigue among patients with breast cancer undergoing chemotherapy. A parallel‐group, randomised controlled trial was conducted. Severely fatigued patients were randomly assigned to the CBT‐AP or usual care (UC) groups using a computer‐generated random sequence. The new intervention was designed for seven sessions: three 2‐hour face‐to‐face and four 30‐minute telephone sessions. The primary outcome (fatigue severity) and the secondary outcomes (depression and QoL) were assessed at the end of the intervention and after 3 months. The data were analysed by repeated measures analyses of covariance (RM‐ANCOVA). CBT‐AP had a significant time effect (P < .001, ηp2 = 0.233) in reducing fatigue from baseline (adjusted mean = 7.48) to the end of the intervention (adjusted mean = 6.37) and the 3‐month follow‐up (adjusted mean = 6.54). Compared to the UC group, the CBT‐AP group had lower fatigue and depression scores, and higher global health status scores. The group × time interaction revealed a significant reduction in fatigue and depression in the CBT‐AP group compared to the UC group. Therefore, CBT‐AP appears to be effective in reducing fatigue and depression and improving QoL in patients with breast cancer undergoing chemotherapy. It is highly recommended to integrate a CBT‐AP intervention in routine cancer care.
Neural network‐based optimization of sub‐diffuse reflectance spectroscopy for improved parameter prediction and efficient data collection
Authors: An Jingyi , Zhang Qi , Zhang Limin , Liu Chenlu , Liu Dongyuan , Jia Mengyu , Gao Feng 
Published: February 2023

AbstractIn this study, a general and systematical investigation of sub‐diffuse reflectance spectroscopy is implemented. A Gegenbauer‐kernel phase function‐based Monte Carlo is adopted to describe photon transport more efficiently. To improve the computational efficiency and accuracy, two neural network algorithms, namely, back propagation neural network and radial basis function neural network are utilized to predict the absorption coefficient , reduced scattering coefficient and sub‐diffusive quantifier , simultaneously, at multiple source‐detector separations (SDS). The predicted results show that the three parameters can be predicated accurately by selecting five SDSs or above. Based on the simulation results, a four wavelength (520, 650, 785 and 830 nm) measurement system using five SDSs is designed by adopting phase‐lock‐in technique. Furtherly, the trained neural‐network models are utilized to extract optical properties from the phantom and in vivo experimental data. The results verify the feasibility and effectiveness of our proposed system and methods in mucosal disease diagnosis.
Defective Joint Development and Maintenance in GDF6-Related Multiple Synostoses Syndrome
Authors: Yu Tingting , Li Guoqiang , Wang Chen , Li Niu , Yao Ruen , Wang Jian 
Published: February 2023

ABSTRACTMultiple synostoses syndromes (SYNS) are a group of rare genetic bone disorders characterized by multiple joint fusions. We previously reported an SYNS4-causing GDF6 c.1330 T &gt; A (p.Tyr444Asn) mutation, which reduced Noggin-induced GDF6 inhibition and enhanced SMAD1/5/8 signaling. However, the mechanisms by which GDF6 gain-of-function mutation alters joint formation and the comprehensive molecular portraits of SYNS4 remain unclear. Herein, we introduce the p.Tyr443Asn (orthologous to the human GDF6 p.Tyr444Asn) mutation into the mouse Gdf6 locus and report the results of extensive phenotype analysis, joint development investigation, and transcriptome profiling of Gdf6 p.Tyr443Asn limb buds. Gdf6 p.Tyr443Asn knock-in mice recapitulated the morphological features of human SYNS4, showing joint fusion in the wrists, ankles, phalanges, and auditory ossicles. Analysis of mouse embryonic forelimbs demonstrated joint interzone formation defects and excess chondrogenesis in Gdf6 p.Tyr443Asn knock-in mice. Further, RNA sequencing of forelimb buds revealed enhanced bone formation and upregulated bone morphogenetic protein (BMP) signaling in mice carrying the Gdf6 p.Tyr443Asn mutation. Because tightly regulated BMP signaling is critical for skeletal development and joint morphogenesis, our study shows that enhancing GDF6 activity has a significant impact on both prenatal joint development and postnatal joint maintenance. © 2023 American Society for Bone and Mineral Research (ASBMR).
Laparoscopic versus open pancreaticoduodenectomy with major vein resection for pancreatic head cancer
Authors: Sung Min Kyu , Song Ki Byung , Hong Sarang , Park Yejong , Kwak Bong Jun , Jun Eunsung , Lee Woohyung , Lee Jae Hoon , Hwang Dae Wook , Kim Song Cheol 
Published: February 2023

AbstractBackground/PurposeLaparoscopic pancreaticoduodenectomy (PD) with major vein resection is a challenging procedure. Herein, we evaluated the feasibility and safety of laparoscopic vein resection in pancreatic head cancer with portal vein/superior mesenteric vein (PV/SMV) invasion, and compared the survival rate following laparoscopic surgery with that following open surgery.MethodsWe retrospectively reviewed the electronic medical records of all patients with pancreatic head cancer who underwent surgery performed by a single surgeon from January 2015 to December 2017. Kaplan–Meier curves were plotted to compare the disease‐free survival, while Cox‐proportional hazard models were used to analyze prognostic factors for survival.ResultsAmong 76 patients, 63 underwent open PD and 13 underwent laparoscopic PD with PV/SMV resection. There was no significant difference in the rate of complications, including portal vein stenosis and portal vein thrombus, recurrence of tumors, or pathological outcomes after surgery between the groups. There was also no significant difference in disease‐free survival (p = .803) between the two groups. Additionally, the surgical method was not an independent prognostic factor for disease‐free survival.ConclusionsLaparoscopic PD with major vein resection can be feasibly performed in select patients with abutment and focal narrowing of the PV/SMV in pancreatic head cancer.