bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZIKV Induction of Tristetraprolin in Endothelial and Sertoli Cells Post-Transcriptionally Inhibits IFNβ/λ Expression and Promotes ZIKV Persistence
Authors: Schutt William R. , Conde Jonas N. , Mladinich Megan C. , Himler Grace E. , Mackow Erich R. 
Published: May 2023

AbstractZika virus (ZIKV) is a mosquito-borneFlavivirusthat persistently infects patients, enters protected brain, placental, and testicular compartments, is sexually transmitted, and causes fetal microcephalyin utero. ZIKV persistently infects brain microvascular endothelial cells (hBMECs) that form the blood-brain-barrier and Sertoli cells that form testicular barriers, establishing reservoirs that enable viral dissemination. ZIKV persistence requires inhibiting interferon (IFN) responses that direct viral clearance. We found that ZIKV induces IFN-β and IFN-λ in hBMECs but post-transcriptionally inhibits IFN-β/λ expression. IFNβ/λ mRNAs contain AU-rich elements (AREs) in their 3’ untranslated regions which regulate protein expression through interactions with ARE binding proteins (ARE-BPs). We found that ZIKV infection of primary hBMECs induces the expression of the ARE-BP tristetraprolin (TTP) and that TTP is a novel regulator of endothelial IFN secretion. In hBMECs, TTP knockout (KO) increased IFN-β/λ1mRNA abundance and IFN-β/λ1secretion in response to ZIKV infection and inhibited viral persistence. In contrast, TTP expression dramatically reduced IFN-β/λ1secretion in hBMECs. IFN-β/λ1mRNA stability was not significantly altered by TTP and is consistent with TTP inhibition of IFN-β/λ1translation. TTP is similarly induced by ZIKV infection of Sertoli cells, and like hBMECs, TTP expression or KO inhibited or enhanced IFN-β/λ mRNA levels, respectively. These findings reveal a mechanism for ZIKV induced TTP to promote viral persistence in hBMECs and Sertoli cells by post-transcriptionally regulating IFN-β/λ secretion. Our results demonstrate a novel role for virally induced TTP in regulating IFN secretion in barrier cells that normally restrict viral persistence and spread to protected compartments.ImportanceOur findings define a novel role for ZIKV induced TTP expression in regulating IFN-β/λ production in primary hBMECs and Sertoli cells. These cells comprise key physiological barriers subverted by ZIKV to access brain and testicular compartments and serve as reservoirs for persistent replication and dissemination. We demonstrate for the first time that the ARE binding protein TTP is virally induced and post-transcriptionally regulates IFN-β/λ secretion. In ZIKV infected hBMEC and Sertoli cells, TTP knockout increased IFN-β/λ secretion, while TTP expression blocked IFN-β/λ secretion. The TTP directed blockade of IFN secretion permits ZIKV spread and persistence in hBMECs and Sertoli cells and may similarly augment ZIKV spread across IFN-λ protected placental barriers. Our work highlights the importance of post-transcriptional ZIKV regulation of IFN expression and secretion in cells that regulate viral access to protected compartments and defines a novel mechanism of ZIKV regulated IFN responses which facilitate neurovirulence and sexual transmission.
An analysis of audit effort/hour demand based on shareholder ownership power
Authors: Mali Dafydd , Lim Hyoungjoo 
Published: May 2023

PurposeAudit hour reporting is rare internationally. Thus, to what extent shareholders have the power to influence audit effort/hour demand is a question left unanswered. This study aims to use unique South Korean data to determine whether the increasing power of the largest foreign/domestic shareholders and blockholders can influence audit hour demand.Design/methodology/approachIn this study ordinary least squares (OLS) regression analysis is conducted using a sample of Korean listed firms over the 2004–2018 sample period.FindingsThe results show: as the percentage equity holding of the largest foreign shareholder and blockholder (>5%) increases, audit hour demand increases. As the shareholding of the largest domestic shareholder increases, audit hour demanded decreases. The association between audit fees/hours is not qualitatively indifferent, after controlling for the audit fee premium effect. Furthermore, the largest foreign shareholder is shown to demand increasingly higher levels of audit hours from Big4 auditors, relative to NonBig4. All results are consistent with audit demand theory.Originality/valueWhilst previous studies offer audit fee/risk interpretations, this study extends the literature by developing a framework to explain why audit hour demands differ for specific groups. Because audit hour information is rare internationally, the study has important policy implications.
Risk assessment in machine learning enhanced failure mode and effects analysis
Authors: Wang Zeping , Du Hengte , Tao Liangyan , Javed Saad Ahmed 
Published: May 2023

PurposeThe traditional failure mode and effect analysis (FMEA) has some limitations, such as the neglect of relevant historical data, subjective use of rating numbering and the less rationality and accuracy of the Risk Priority Number. The current study proposes a machine learning–enhanced FMEA (ML-FMEA) method based on a popular machine learning tool, Waikato environment for knowledge analysis (WEKA).Design/methodology/approachThis work uses the collected FMEA historical data to predict the probability of component/product failure risk by machine learning based on different commonly used classifiers. To compare the correct classification rate of ML-FMEA based on different classifiers, the 10-fold cross-validation is employed. Moreover, the prediction error is estimated by repeated experiments with different random seeds under varying initialization settings. Finally, the case of the submersible pump in Bhattacharjee et al. (2020) is utilized to test the performance of the proposed method.FindingsThe results show that ML-FMEA, based on most of the commonly used classifiers, outperforms the Bhattacharjee model. For example, the ML-FMEA based on Random Committee improves the correct classification rate from 77.47 to 90.09 per cent and area under the curve of receiver operating characteristic curve (ROC) from 80.9 to 91.8 per cent, respectively.Originality/valueThe proposed method not only enables the decision-maker to use the historical failure data and predict the probability of the risk of failure but also may pave a new way for the application of machine learning techniques in FMEA.
Confidence and change in entrepreneurial plan upon reentry: examining the effects in crowdfunding failure
Authors: Fan-Osuala Onochie 
Published: May 2023

PurposeConfidence gives entrepreneurs the belief that they can exercise control and that they have the ability to ensure the success of a focal entrepreneurial endeavor. However, failure can rattle an entrepreneur's confidence causing them to question their belief and ability. This study investigates the link between confidence and entrepreneurial plan upon reentry after crowdfunding failure. Particularly, it examines whether more confident entrepreneurs who failed in their original crowdfunding endeavor persist or change their plan in terms of the positioning of the crowdfunding endeavor and the funding goal in the subsequent attempt.Design/methodology/approachUsing a sample of 2179 serial crowdfunding entrepreneurs who initially experienced failure before launching a subsequent crowdfunding endeavor, this study explores and tests four hypotheses on the relationship between confidence and the change implemented by entrepreneurs in their subsequent crowdfunding endeavors after failure.FindingsThe results suggest that more confident entrepreneurs who experienced failure in their initial crowdfunding endeavor persist in their positioning when they attempt a subsequent endeavor. However, no strong relationship was observed between entrepreneurial confidence and persistence with the funding goal of the initial crowdfunding plan in the subsequent crowdfunding endeavor. The study also finds suggestive but inconclusive evidence that the level of negative performance in the failed crowdfunding endeavor moderates the relationship between the entrepreneur's confidence and change in crowdfunding positioning.Originality/valueThis study provides new insights into the effect of entrepreneurial confidence on crowdfunding endeavors after an initial failure. Prior research has focused on its effect in driving the performance of crowdfunding endeavors rather than on how it may affect the plan in terms of the positioning and funding goal enacted by the entrepreneur after experiencing failure.
Effect of market-based regulations on corporate carbon disclosure and carbon performance: global evidence
Authors: Siddique Md Abubakar , Aljifri Khaled , Hossain Shahadut , Choudhury Tonmoy 
Published: May 2023

PurposeIn this study, the authors examine the relationships between market-based regulations and corporate carbon disclosure and carbon performance. The authors also investigate whether these relationships vary across emission-intensive and non-emission intensive industries.Design/methodology/approachThe study sample consists of the world's 500 largest companies across most major industries over a recent five-year period. Country-specific random effect multiple regression analysis is used to test empirical models that predict relationships between market-based regulations and carbon disclosure and carbon performance.FindingsResults indicate that market-based regulations significantly and positively affect corporate carbon performance. However, market-based regulations do not significantly affect corporate carbon disclosure. This study also finds that the association between regulatory pressures and carbon disclosure and carbon performance varies across emission-intensive and non-emission-intensive industries.Research limitations/implicationsThe findings of this study have key implications for policymakers, practitioners and future researchers in terms of understanding the factors that drive businesses to increase their carbon performance and disclosure. The study sample consists of only large firms, and future researchers can undertake similar studies with small and medium-sized firms.Practical implicationsThe results of this study are expected to help business managers to identify the benefits of adopting market-based regulations. Regulators can use this study’s results to evaluate if market-based regulations effectively improve corporate carbon performance and disclosure. Furthermore, stakeholders may use this study to evaluate and improve their businesses' reporting of carbon disclosure and performance.Originality/valueIn contrast to current literature that has used command and control regulations as a proxy for regulation, this study uses market-based regulations as a proxy for climate change regulations. In addition, this study uses a more comprehensive measure of carbon disclosure and carbon performance compared to the previous studies. It also uses global multi-sector data from carbon disclosure project (CDP) in contrast to most current studies that use national data from annual reports of sample firms of specific sectors.
La Antigua Guatemala living heritage. Improving governance for sustainable development
Authors: Ramírez de León Mario Raúl , Wolley Schwarz Claudia Blanca Verónica , Molina Soto María Elena , Ruiz Olga Edith , Ixquiaptap Tuc María Magdalena , García Valdez Josué Roberto 
Published: May 2023

PurposeThis paper discusses how the Heritage Place Lab (HPL) Pilot Phase, led by International Centre for the Study of Preservation and Restoration of Cultural Property (ICCROM) and the International Union for Conservation of Nature (IUCN) (2021–2022), supported La Antigua Guatemala (LAG) World Heritage Site as a case study to identify research gaps to strengthen HPL's management through a collaborative process between research and practice teams.Design/methodology/approachA qualitative method was adopted that followed the collaborative process proposed for the HPL Pilot Phase. An adapted version of the Enhancing Our Heritage (EoH) Toolkit 2.0 (forthcoming) was applied. The HPL served as an incubator for on-going research projects, with LAG acting as one of eight case studies.FindingsTo achieve sustainable development at the site, strengthening the governance model is a priority. This should focus on adopting a more comprehensive management approach that includes the surrounding areas and new values that have been identified since the approach's inscription in 1979 as well as addressing the impacts of climate change.Research limitations/implicationsThe study finds that this task is essential to widely disseminate and follow up the findings made between researchers and site managers as well as to propose a new governance model alongside associated changes in conservation and municipal and national legislation. Therefore, long-term political support and commitment from institutions, authorities and stakeholders involved in the management and conservation of LAG will be essential.Social implicationsAll sectors and institutions in the local community should be involved in the conservation and development of LAG and its surrounding areas. Local communities should benefit from a more effective and inclusive model of governance that recognises and enhances the communities' values as part of communities' identity and quality of life. Climate change mitigation and risk-prevention programmes should also be put in place.Originality/valueTo date, research in LAG has been disparate and has not responded to LAG's management needs that result from LAG's complexity as a living historical city. This paper demonstrates the contribution that collaborative work can make between researchers and site managers to identifying, prioritising and proposing solutions to the challenges facing World Heritage Sites.
The influence of need for cognition and need for emotion on elderly responses to advertising: an exploratory study and implications for change in management
Authors: Safraou Imen , Guiot Denis 
Published: May 2023

PurposeThis paper examines the relationship between “chronological age” and the individual difference variables: “Need for cognition” (NFC) and “Need for emotion” (NFE). More specifically, this study investigates the influence of these individual difference variables on elderly responses towards advertising.Design/methodology/approachThis study is based on a sample of 600 individuals. 300 elderly aged between 60 and 75 years old (average age: 67.67 years old), recruited from institutions and third age universities in Paris and 300 young adults, aged between 20 and 35 years old (average age: 25.14 years old) from academic institutions in Paris.FindingsThe findings show that NFC and NFE have different levels depending on age. Indeed, NFC is lower among older than younger individuals, and NFE is higher among older than younger individuals. Moreover, different levels in NFC and NFE may affect responses to ads. Thus, a high NFC can elicit more favorable cognitive responses to ads and a high NFE triggers more favorable affective responses.Research limitations/implicationsThe study investigates specifically the effects of chronological age on the individual difference variables NFC and NFE; however, the influence of chronological age on these individual variables may be affected by other variables such as subjective age, level of education and physical condition.Practical implicationsGiven that NFC and NFE are dynamic variables that change with age and that they influence responses to advertising, it would be necessary to take them into account and to integrate them when building management persuasion models specifically targeting the elderly.Originality/valueThis study focuses on the influence of individual variables (NFE and NFC) on responses to advertising, of an underexplored population: the elderly. This could help to better understand the persuasion mechanisms when it comes to targeting the elderly both outside and inside organizations, with deriving implications for change in management.
Zoom Communication Inc.: keeping the good times going?
Authors: Ahmadsimab Alireza , Tajeddin Mahdi , Fralich Russell 
Published: May 2023

Purpose
The purpose of this study is to describe how Zoom became the tope video conferencing service across the globe.

Research methodology
This case was developed from secondary sources including industry reports, academic, newspaper, periodical sources, company annual reports, social media sites and company websites. This case has been classroom tested with undergraduates in a strategic management course as a capstone course.

Case overview/synopsis
The case study describes the rapid growth of Zoom Communications Inc., a San Jose based publicly traded video conferencing company founded in 2011 by Eric Yuan. It illustrates the competition in the online meeting solutions industry in late 2020, during the COVID-19 lockdown. To explain how Zoom became the top video conferencing service across the globe, the case highlights the attractiveness of the market and the competitive advantage of Zoom over its rivals. Students can evaluate the internal capabilities and competencies of Zoom as well as identify key challenges in the external environment for sustaining Zoom’s competitive advantage.

Complexity academic level
This case study is suitable for strategic management classes for upper-level undergraduates and at the graduate level for MBA and/or master students. It prepares students to discuss core concepts in strategy, such as competitive strategy and competitive forces that shape strategy.
A bubble identification mechanism: Evidence from the Chinese stock market
Authors: He Chaolin , Gao Yijia , Xiao Feng , Tang Liangling , Khan Yasir 
Published: May 2023

AbstractThis paper provides a bubble date‐stamping mechanism using the agent‐based computational finance method. The key steps of the bubble date‐stamping mechanism are the construction of the simulated financial market, the computation of the characteristic indexes, and the thresholds of the Price Band in the simulated financial market. The present study adopts the mechanism to identify the bubbles of sample stocks in the Chinese stock market from April 2003 to December 2019. The findings show that the bubbles are primarily distributed in 2006–2008, 2009–2012 and 2014–2018, respectively. Furthermore, we analyse the bubble strength and the price fluctuation during the above three periods. In addition to the bubble date‐stamping mechanism, the paper also studies the factors that drive the bubbles in the Chinese stock market from both macro and micro perspectives.
Homicidal electrocution disguised as an accidental death
Authors: Meshram Vikas Premlal. , Shekhawat Raghavendra Singh , Ayyappan Sathish , Rao Meenakshi , Kanchan Tanuj 
Published: May 2023

AbstractDeaths due to electrocution are mostly accidental. Homicide by electrocution is rarely reported in the literature. However, the location and pattern of the electrocution wound can raise concern for a possible homicidal manner of death. We are reporting an unusual case wherein the dead body of a middle‐aged man was found lying in a suspicious condition on the roadside of desolated area. There were circumferential, grooved electrocution lesions over the left and right second toes with oval electrocution lesions on the medial aspects of both the left and right third toes. There were split lacerations over the right high parietal region, right pinna, and forehead. There was avulsion of the nail of the left thumb. Pressure abrasion was consistent with a ligature mark on the lower part of the left leg. The locations and pattern of these injuries raised the possibility of torture infliction. Death was attributed to electrocution, which was confirmed by histopathology. Autopsy findings and possible inferences were furnished to the police. This case highlights the careful observation of different characterizations and locations of the wounds and deducing inferences about the possible manner of death. This information can be useful to investigating agencies.
Moving policies toward racial and ethnic equality: The case of the supplemental nutrition assistance program*
Authors: Flores‐Lagunes Alfonso , Jales Hugo B. , Liu Judith , Wilson Norbert L. 
Published: May 2023

AbstractWe analyze the role played by the Supplemental Nutrition Assistance Program (SNAP) in alleviating or exacerbating inequality across racial and ethnic groups in food expenditures and in the resources needed to meet basic food needs (the “food resource gap”). To do this, we propose a simple framework that decomposes differences across groups in SNAP benefit transfer levels into three components: eligibility, participation, and generosity. This decomposition is then linked to differences in food expenditures and the food resource gap. Our results reveal that among the three components, differences in eligibility contribute the most to SNAP benefits differentials for Black and Hispanic households relative to White households. Given that SNAP is often a target of policy changes, we employ the framework to provide counterfactual analyses of how selected SNAP policy changes can impact group differences in benefits and, ultimately, disparities in food expenditures and the food resource gap. The proposed framework can be applied to analyze other safety net programs.
Anatomical endoscopic retrograde cholangiopancreatography simulator using moulded meshed silicone: A novel simulator pilot study
Authors: Brodaric Alen Maximillian , Wong Ngar Lok Joshua , Falon Jessica , Wong Jean , Cheng Kai , Whereat Sarah , Storey David 
Published: May 2023

AbstractIntroductionEndoscopic retrograde cholangio‐pancreatography (ERCP) has higher rates of morbidity and mortality compared to upper or lower gastrointestinal tract endoscopy. The availability of magnetic resonance cholangiopancreatography means ERCP is usually performed for therapeutic purposes. Simulation could provide an adjunct to patient‐based training in ERCP however models to date have been unconvincing.MethodsThis ERCP simulation model was constructed from moulded meshed silicone by co‐designers: Jean Wong and Kai Cheng. The anatomical orientation was based on a combination of anatomical specimens, sectional atlases, and the clinical experience of expert endoscopists.ResultsFrom March to October 2022, we recruited 5 surgeons/gastroenterologists to the expert group and 14 medical students, junior doctors, or surgical/gastroenterological trainees to the novice group. Most experts either agreed or strongly agreed that the simulation anatomy appearance (100%), anatomical orientation (83%), tactile feedback (66%), traversal actions (67%), cannula positioning (66%) and papilla cannulation (67%) resembled the procedure in humans. Experts statistically significantly outperformed novices in obtaining a cannulating position (80% vs. 14%, P = 0.006) and successful papilla cannulation (80% vs. 7%, P = 0.0015) on their first attempt. The novice group had statistically significant improvements in time to obtaining a cannulating position (3.53 vs. 11.5 min, P = 0.006) and passing the duodenoscope to the papilla (2.55 vs. 4 passes, P = 0.009).ConclusionsThe simulator showed statistically significant results in face, content, and construct validity. A follow‐up validation study should recruit participants across multiple institutions. External validity could be assessed by comparing expert proceduralist simulator performance against clinical ERCP performance.