bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal trends in the cost and use of first‐line treatments for infantile epileptic spasms syndrome
Authors: Sánchez Fernández Iván , Amengual‐Gual Marta , Barcia Aguilar Cristina , Romeu Amanda , Sheikh Tahir , Torres Alcy , Chao Jessica , Jonas Rinat , Gaínza‐Lein Marina , Harini Chellamani , Douglass Laurie 
Published: January 2023

AbstractObjectiveTo describe the temporal trends in the cost and use of adrenocorticotropic hormone (ACTH), oral prednisolone, and vigabatrin, the first‐line treatments for infantile epileptic spasms syndrome (IESS).MethodsRetrospective observational study using the MarketScan Commercial database from 2006 to 2020. We identified patients with IESS diagnosed between birth and 18 months of age who received at least one of the first‐line treatments within 60 days of diagnosis. Costs were adjusted for inflation using the Gross Domestic Product Implicit Price Deflator.ResultsA total of 1131 patients received at least one first‐line treatment (median [p25–p75] age: 6.3 [4.5–8.3] months, 55% male), of whom 592 patients received ACTH, 363 patients received oral prednisolone, and 355 patients received vigabatrin. After adjusting for inflation, the median average wholesale price of a 14‐day course of treatment increased for ACTH from $3718 in 2006 to $100 457 in 2020, ~2700% (by a factor of 27), whereas it decreased for oral prednisolone from $169 in 2006 to $89 in 2020, ~50% (by a factor of 0.5), and increased for vigabatrin from $1206 in 2009 (first year with data on vigabatrin used for IESS) to $4102 in 2020, ~340% (by a factor of 3.4). During the first 60 days after diagnosis, inpatient admission days and costs where higher for ACTH than for oral prednisolone and vigabatrin—5.0 (3.0–8.3) days vs 2.0 (0.0–5.0) days vs 2.0 (0.0–6.0) days, p < .0001; and $32 828 ($14 711–$67 216) vs $16 227 ($0–$35 829) vs $17 844 ($0–$47 642), p < .0001. ACTH use decreased from representing 78% of first‐line treatments in 2006 to 18% in 2020 (p < .0001). Sensitivity analyses confirmed the robustness of the results.SignificanceThe gap between the cost of ACTH and the cost of oral prednisolone or vigabatrin has widened markedly from 2006 to 2020, whereas the relative proportion of ACTH use has decreased.
Damage evolution and life modeling of hot corrosion environment on creep‐fatigue of a directionally solidified nickel‐based superalloy
Authors: Hu Jianhui , Zhao Gaole , Li Shaolin , Qi Hongyu , Yang Xiaoguang , Shi Duoqi 
Published: January 2023

AbstractThis study developed a corrosion‐creep fatigue‐life‐prediction methodology based on continuous‐damage mechanics (CDM). A systematic investigation of the turbine‐blade material DZ125 (a nickel‐based superalloy) was conducted, including oxidation and high‐temperature hot corrosion‐creep fatigue tests. Pre‐exposure experiments explained the damage process in DZ125. The applicability of the CDM‐based life‐prediction model of DZ125 was verified experimentally and by comparison with corresponding data from published studies. The model exhibited excellent life‐prediction ability for gas‐turbine hot‐section components vulnerable to cyclic loads and hot corrosion combined.
Beyond the usual suspects: Invisible labour(ers) in futures of work
Authors: Gilbert Evie 
Published: January 2023

AbstractInvisible labour exists within all forms of work. In looking to the future of work (FoW), this article reviews the literature on two separate examples; digital work and the 4IR, to uncover invisible labour within these futures. The focus of this article remains on paid work but recognises that ‘employed’ does not correlate with visible. In contributing to feminist labour geography, this review aims to collate, regroup and evaluate the literature on the FoW in a way which recognises ‘invisible labourers’ through redefining ‘work’ and expanding our perception of the ‘workplace’. It does so in three parts. First, feminist labour geography literature is reviewed to situate the article within its call to broaden the definition of ‘work’. Second, the review addresses digital work and the gig economy, to establish which labourers are receiving the most current academic attention and are, therefore, visible. Feminist literature on work and labourers within unrecognised economic spaces is explored through the example of digital sex work to draw on the concept of ‘invisible labour’ in digital FoW. Third, literature on technologies of the 4IR and labour will be reviewed, with particular reference to the global north bias in FoW studies. Finally, the review will apply the regrouping of the literature to the impending wave of automation in the global garment industry. The article identifies a risk of further invisibalising already precarious and marginalised garment workers and the FoW narrative moves beyond low‐skill labour. Highlighting the wider impacts on the FoW, beyond technology itself, this article calls for the labour geography literature to recognise the shift in our conception of ‘industry’ and women's experience of work within it to encompass invisible labourers' roles which are created, mediated and maintained by new technologies.
Whose geography do we review?
Authors: Crane Nicholas Jon , Ergler Christina , Griffin Paul , Holton Mark , Rhiney Kevon , Robinson Caitlin , Simon Gregory 
Published: January 2023

AbstractIn the context of discipline‐wide efforts to produce more inclusive, just, and equitable norms of geographical knowledge production, section editors for Geography Compass identify five concrete practices by which to address systemic inequities, injustices, and exclusions through their editorial work.
A qualitative evidence synthesis of patient perspectives on migraine treatment features and outcomes
Authors: Urtecho Meritxell , Wagner Brittin , Wang Zhen , VanderPluym Juliana H. , Halker Singh Rashmi B. , Noyes Jane , Butler Mary E. , Murad Mohammad Hassan 
Published: January 2023

AbstractObjectivesWe aimed to identify migraine treatment features preferred by patients and treatment outcomes most valued by patients.BackgroundThe values and preferences of people living with migraine are critical for both the choice of acute therapy and management approach of migraine.MethodsWe conducted a qualitative evidence synthesis. Two reviewers independently selected studies, appraised methodological quality, and undertook a framework synthesis. We developed summary of findings tables following the approach of Grading of Recommendations, Assessment, Development and Evaluations Confidence in the Evidence from Reviews of Qualitative Research to assess confidence in the findings.ResultsOf 1691 candidate references, we included 19 studies (21 publications) involving 459 patients. The studies mostly recruited White women from North America (11 studies) and Europe (8 studies). We identified eight themes encompassing features preferred by patients in a migraine treatment process. Themes described a treatment process that included shared decision‐making, a tailored approach, trust in health‐care professionals, sharing of knowledge and diversity of treatment options, a holistic approach that does not just address the headache, ease of communication especially for complex treatments, a non‐undermining approach, and reciprocity with mutual respect between patient and provider. In terms of the treatment itself, seven themes emerged including patients’ preferences for nonpharmacologic treatment, high effectiveness, rapidity of action, long‐lasting effect, lower cost and more accessibility, self‐management/self‐delivery option that increases autonomy, and a mixed preference for abortive versus prophylactic treatments. The treatment outcomes that have high value to patients included maintaining or improving function; avoiding side effects, potential for addiction to medications, and pain reoccurrence; and avoiding non‐headache symptoms such as nausea, vomiting, and sensitivity to light or sounds.ConclusionPatient values and preferences were individually constructed, varied widely, and could be at odds with conventional medical perspectives and evidence of treatment effects. Considering the availability of numerous treatments for acute migraine, it is necessary that decision‐making incorporates patient values and preferences identified in qualitative research. The findings of this qualitative synthesis can be used to facilitate an individually tailored approach, strengthen the patient–health‐care system relationship, and guide choices and decisions in the context of a clinical encounter or a clinical practice guideline.
Cabozantinib in Japanese patients with advanced hepatocellular carcinoma: Final results of a multicenter phase II study
Authors: Kato Naoya , Kudo Masatoshi , Tsuchiya Kaoru , Hagihara Atsushi , Numata Kazushi , Aikata Hiroshi , Inaba Yoshitaka , Kondo Shunsuke , Motomura Kenta , Okano Naohiro , Ikeda Masafumi , Morimoto Manabu , Kuroda Shingo , Kimura Akiko 
Published: January 2023

AbstractAimCabozantinib showed a favorable benefit–risk profile in Japanese patients with advanced hepatocellular carcinoma (HCC) in an open‐label, phase II study (NCT03586973). This analysis presents cumulative data to final database lock.MethodsPatients with previously treated, advanced HCC received cabozantinib 60 mg/day. Progression‐free survival (PFS) and tumor response rates in prior‐sorafenib and sorafenib‐naïve cohorts were assessed by independent radiology committee (IRC) and an investigator. Liver function was evaluated by albumin–bilirubin (ALBI) score.ResultsMedian cabozantinib exposure was 5.6 months. In the prior‐sorafenib cohort (n = 20), median PFS was 7.4 months per IRC assessment and 5.6 months per investigator assessment. In the sorafenib‐naïve cohort (n = 14), median PFS was 3.6 and 4.4 months per IRC and investigator assessment, respectively. Six‐month PFS rate per IRC and investigator assessment in the prior‐sorafenib cohort was 59.8% and 49.5%, respectively, and in the sorafenib‐naïve cohort was 16.7% and 35.7%, respectively. Disease control rate by both IRC and investigator assessment was 85.0% in the prior‐sorafenib cohort and 64.3% in the sorafenib‐naïve cohort. Median overall survival (Kaplan–Meier estimate) was 19.3 and 9.9 months in the prior‐sorafenib and sorafenib‐naïve cohort, respectively. Mean ALBI score remained relatively constant in patients able to continue treatment. The most frequent adverse events were palmar–plantar erythrodysesthesia syndrome, diarrhea, hypertension, and decreased appetite. No new safety concerns were identified.ConclusionsCabozantinib showed efficacy and a manageable safety profile in Japanese patients with advanced HCC.
Psychoeducational interventional programme during the COVID‐19 pandemic for nurses with severe occupational stress: A randomized controlled trial
Authors: Alkhawaldeh Ja'far M. 
Published: January 2023

AbstractBackground:Occupational stress is generally acknowledged as a major issue in the health sector that may have a detrimental impact on nurses' psychological and physical health, particularly during the COVID‐19 epidemic.Aim:This study evaluated the effectiveness of a psychoeducational interventional programme in decreasing occupational stress and improving coping methods among nurses during the COVID‐19 pandemic.Methods:This study used a cluster‐randomized approach. Data were collected from 80 nurses working in two public health‐care centres from May to August 2020 in Jordan. Two centres were assigned randomly to the intervention and control groups. The psychoeducational programme was delivered to the intervention group in six sessions over 6 days for 2 weeks. The collected data were analysed using SPSS through descriptive and inferential statistics. Occupational stress and coping strategies were measured.Results:Repeated‐measures analysis of variance (ANOVA) indicated that the degrees of occupational stress and coping strategies significantly differed between study groups over the three points of data collection.Conclusion:This psychoeducational interventional programme is a valuable noninvasive method that can improve individual coping strategies to manage stress in practice during the COVID‐19 pandemic.
Dispositional and situational attributions for why the rich live longer than the poor
Authors: Bridger Emma K. , Tufte‐Hewett Angela , Comerford David A. 
Published: January 2023

AbstractDespite considerable focus on predictors of attitudes towards economic inequality, there is less psychological research into attitudes towards other unequal outcomes between the rich and poor, including differences in health and life expectancy. Two studies examine whether causal attributions for these socioeconomic health inequalities predict attitudes towards them. A cross‐sectional study of 332 UK and US respondents showed that most respondents indicate a preference for some degree of income inequality but no life expectancy inequality between the richest and poorest in society. These preferences for equal life expectancy for the rich and poor were significantly less likely for respondents who viewed health inequalities to be caused by dispositional factors (e.g., self‐control, ability or effort). In a second pre‐registered cross‐sectional study (n = 602), dispositional attributions negatively predicted self‐reported concern about health inequality, whilst endorsing situational attributions (e.g., discrimination and prejudice, wages) was positively associated with concerns on this issue. Moreover, situational attributions positively predicted support for six policy proposals for reducing health inequality, while dispositional attributions were associated with increased support for some of these interventions and decreased support for others. Despite very distinct distribution preferences for income and life expectancy outcomes, causal attributions continue to predict attitudes towards health inequality and associated policy interventions.
SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression
Authors: Li Bing , Dang Xiaoqian , Duan Jiafeng , Zhang Guangyang , Zhang Jia , Song Qichun 
Published: January 2023

AbstractMetabolism reprogramming plays an important role in tumorigenesis and osteosarcoma metastasis. Sine oculis homeobox 4 (SIX4) is reported to be a key transcription factor that is involved in glycolysis reprogramming of cancer cells. However, the role of SIX4 in osteosarcoma progression remains unknown. The expression profile of SIX4 in OS was evaluated in surgery samples of osteosarcoma patients. Functional studies were performed in vitro and in vivo. We found that SIX4 is significantly overexpressed in osteosarcoma and related to the undesirable prognosis of osteosarcoma patients. SIX4 promotes progression of osteosarcoma via upregulating isocitrate dehydrogenase 1 (IDH1), which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.
Influence of alveolar bone height on the biomechanical behavior of roots restored with custom‐made posts‐and‐cores
Authors: Gontijo Isabela Guerra , Ferretti Marcela Alvarez , Monteiro Lara Christie , Caldas Ricardo Armini , Pecorari Vanessa Gallego Arias , França Fabiana Mantovani Gomes , Aguiar Flávio Henrique Baggio 
Published: January 2023

AbstractObjetiveThis study evaluated the influence of alveolar bone height and post type on compressive force resistance, fracture pattern, and stress distribution in endodontically treated teeth.Materials and MethodsBovine roots were endodontically treated and divided into eight groups (n = 10) according to alveolar bone height (normal alveolar bone and alveolar bone loss ‐ 2 and 5 mm from the margin of the crown, respectively) and post type (prefabricated glass fiber post, anatomic glass fiber post, customized milled glass fiber post‐and‐core and customized milled polyetheretherketone (PEEK) post‐and‐core). Mechanical fatigue was simulated (300.000 cycles/50 N/1.2 Hz). Compression force resistance (N) was analyzed by two‐way ANOVA and Tukey test (α = 0.05). Fracture patterns were described as percentages. Stress distribution was analyzed by finite element analysis.ResultsSignificant diferences were found for alveolar bone height (P < 0.0001): normal alveolar bone groups showed higher mean values of compression force resistance compared to alveolar bone loss groups, while no significant differences were found for post type (P = 0.4551), and there was no double interaction between them (P = 0.5837). Reparable fractures were more predominant in normal alveolar bone groups, especially in the milled glass fiber and PEEK post‐and‐core groups. Stress distribution was similar in groups with prefabricated glass fiber posts and milled PEEK posts‐and‐cores, and the alveolar bone loss condition significantly increased stress concentration and strain values, mainly on apical dentin.ConclusionsAlveolar bone loss due to physiological aging and/or periodontal disease may lead to increased risk of restored tooth failure, although milled glass fiber and PEEK posts‐and‐cores provide more reparable fractures.Clinical SignificanceCustom‐made glass fiber and PEEK post‐and‐cores are interesting options, since they enable clinicians to work with a single‐body post‐and‐core system that avoid several materials interfaces and fits well in the root canal provided promising results to improve the failure behavior of restored roots, as they offer more reparable fractures even in situations of alveolar bone loss.
Behavioural adjustment of children with intellectual disability and their sibling is associated with their sibling relationship quality
Authors: Hayden N. K. , Hastings R. P. , Bailey T. 
Published: January 2023

AbstractBackgroundUnderstanding sibling relationship quality is important, as it is associated with mental health outcomes in both childhood and adulthood. Arguably, these relationships are even more important for individuals with intellectual disability, as siblings can be important sources of care, support, advocacy and friendship for one another. The intellectual disability field, however, has a tendency to assume that the relationship lacks reciprocity, and that it is the sibling with intellectual disability who affects the sibling, and that this effect is somehow ‘negative’.MethodsWe examined whether the behaviour problems and prosocial behaviour of 500 child sibling pairs, where one child has an intellectual disability, were associated with their sibling relationship quality. Measures included the Strengths and Difficulties Questionnaires and the Sibling Relationship Questionnaire. Family poverty, the gender of both children, birth order and whether the child with intellectual disability had autism or Down syndrome were also included in the analyses.ResultsConfirmatory factor analysis indicated an adequate model fit for the latent variables measuring sibling relationships. The final structural model found that the prosocial behaviour and internalising problems of the children with intellectual disability, their typically developing siblings' prosocial behaviours and sibling birth order were associated with intimacy–companionship in the sibling relationship. The internalising, externalising and prosocial behaviours of the children with intellectual disability, their siblings' externalising behaviours and sibling birth order were associated with antagonism–quarrelling in the sibling relationship.ConclusionsWe found that the behaviours of both the child with intellectual disability and their sibling were associated with both ‘positive’ and ‘negative’ dimensions of their sibling relationship. This indicates a bidirectional and reciprocal effect.
A short review of acculturation and addiction among immigrant and refugee communities in the United States and abroad
Authors: Marginean Valentina , Sheth Pankti , Varma Ashima , Vessie Arden 
Published: January 2023

AbstractPurposeTo summarize recent evidence of the relationship between acculturation and substance use addiction among foreign‐born persons living in the United States (U.S.) and abroad.Recent findingsForeign‐born populations are increasing in many countries as a result of immigration and global refugee displacement. Acculturation and discrimination toward both populations have been related to the initiation of illicit substance use. The “immigrant paradox” may serve as a protective factor against the initiation and worsening prognosis of substance use disorders. Improving multilingual accessibility and frequency of use of clinical screeners may enhance addiction risk factor identification and potential interventions for foreign‐born populations living in countries of emigration, such as the U.S.SummaryForeign‐born persons compose a significant proportion of nurse–patient interactions in the U.S. and abroad. The unique sociological phenomenon of the immigrant paradox may serve as a protective factor for foreign‐born persons despite the increased risk for adverse childhood events, acculturation, and discrimination. Due to conflicting evidence, future studies should examine longitudinal outcomes of substance use exclusively among foreign‐born persons as well as protective and risk factors associated with immigrants and refugees, respectively.Clinical relevanceForeign‐born persons may experience unique risk factors associated with addiction. Future studies should focus on foreign‐born populations to explore if social constructs surrounding addiction can be extrapolated into other populations, including their second‐generation offspring. Differences surrounding migration contexts between immigrants and refugees may be important for clinical researchers to understand when designing research studies centered on these experiences. Nurses can play a significant role in identifying patients at risk for substance use by advocating for inclusive and comprehensive multilingual screeners.
MRI detection of brain gadolinium retention in multiple sclerosis: Magnetization transfer vs. T1‐weighted imaging
Authors: Cananau Carmen , Forslin Yngve , Bergendal Åsa , Sjöström Henrik , Fink Katharina , Ouellette Russell , Wiberg Maria Kristoffersen , Fredrikson Sten , Granberg Tobias 
Published: January 2023

AbstractBackground and PurposeEvidence of brain gadolinium retention has affected gadolinium‐based contrast agent usage. It is, however, unclear to what extent macrocyclic agents are retained and whether their in vivo detection may necessitate nonconventional MRI. Magnetization transfer (MT) could prove suitable to detect gadolinium‐related signal changes since dechelated gadolinium ions bind to macromolecules. Therefore, this study aimed to investigate associations of prior gadolinium administrations with MT and T1 signal abnormalities.MethodsA cohort of 23 persons with multiple sclerosis (MS) (18 females, 5 males, 57 ± 8.0 years) with multiple past gadolinium administrations (median 6, range 3‐12) and 23 age‐ and sex‐matched healthy controls underwent 1.5 Tesla MRI with MT, T1‐weighted 2‐dimensional spin echo, and T1‐weighted 3‐dimensional gradient echo. The signal intensity index was assessed by MRI in gadolinium retention predilection sites.ResultsThere were dose‐dependent associations of the globus pallidus signal on gradient echo (r = .55, p < .001) and spin echo (r = .38, p = .013) T1‐weighted imaging, but not on MT. Relative to controls, MS patients had higher signal intensity index in the dentate nucleus on T1‐weighted gradient echo (1.037 ± 0.040 vs. 1.016 ± 0.023, p = .04) with a similar trend in the globus pallidus on T1‐weighted spin echo (1.091 ± 0.034 vs. 1.076 ± 0.014, p = .06). MT detected no group differences.ConclusionsConventional T1‐weighted imaging provided dose‐dependent associations with gadolinium administrations in MS, while these could not be detected with 2‐dimensional MT. Future studies could explore newer MT techniques like 3D and inhomogenous MT. Notably, these associations were identified with conventional MRI even though most patients had not received gadolinium administrations in the preceding 9 years, suggestive of long‐term retention.