bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoimmune rheumatic diseases in women with coronary microvascular dysfunction: a report from the Women's Ischemia Syndrome Evaluation—Coronary Vascular Dysfunction (WISE-CVD) project
Authors: Chen Melanie T. , Chang Joseph , Manchanda Ashley S. , Cook-Wiens Galen , Shufelt Chrisandra L. , Anderson R. David , Petersen John W. , Naik Dhaval R. , Thomson Louise E. J. , Berman Daniel S. , Handberg Eileen M. , Pepine Carl J. , Bairey Merz C. Noel , Wei Janet 
Published: May 2023

BackgroundWhile autoimmune rheumatic diseases (ARDs) have been linked with coronary microvascular dysfunction (CMD), the relationship between ARD and CMD in women with signs and symptoms of ischemia and no obstructive arteries (INOCA) are not well described. We hypothesized that among women with CMD, those with ARD history have greater angina, functional limitations, and myocardial perfusion compromise compared to those without ARD history.MethodsWomen with INOCA and confirmed CMD by invasive coronary function testing were included from the Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) project (NCT00832702). Seattle Angina Questionnaire (SAQ), Duke Activity Status Index (DASI), and cardiac magnetic resonance myocardial perfusion reserve index (MPRI) were collected at baseline. Chart review was performed to confirm self-reported ARD diagnosis.ResultsOf the 207 women with CMD, 19 (9%) had a confirmed history of ARD. Compared to those without ARD, women with ARD were younger (p = 0.04). In addition, they had lower DASI-estimated metabolic equivalents (p = 0.03) and lower MPRI (p = 0.008) but similar SAQ scores. There was a trend towards increased nocturnal angina and stress-induced angina in those with ARD (p = 0.05 for both). Invasive coronary function variables were not significantly different between groups.ConclusionsAmong women with CMD, women with a history of ARD had lower functional status and worse myocardial perfusion reserve compared to women without ARD. Angina-related health status and invasive coronary function were not significantly different between groups. Further studies are warranted to understand mechanisms contributing to CMD among women with ARDs with INOCA.
Mindfulness-based stress reduction combined with early cardiac rehabilitation improves negative mood states and cardiac function in patients with acute myocardial infarction assisted with an intra-aortic balloon pump: a randomized controlled trial
Authors: Wu Kemei , Wan Miaomiao , Zhou Huiqin , Li Cui , Zhou Xiaomin , Li E. , Li Ying , Liu Chengwei , Liu Li 
Published: May 2023

ObjectiveTo investigate the clinical effects of mindfulness-based stress reduction (MBSR) intervention combined with early cardiac rehabilitation (CR) on patients with acute myocardial infarction (AMI) assisted with an intra-aortic balloon pump (IABP).MethodsA total of 100 AMI patients with IABP assistance due to hemodynamic instability at Wuhan Asia Heart Hospital were enrolled in the study. The participants were divided into two groups using the random number table method (n = 50 each group). Patients receiving routine CR were assigned to the CR control group, while patients receiving MBSR plus CR were assigned to the MBSR intervention group. The intervention was performed twice a day until the removal of the IABP (5–7 days). Each patient's level of anxiety/depression and negative mood state were evaluated before and after intervention using the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and profiles of mood state scale (POMS). The results of the control and intervention groups were compared. IABP-related complications and left ventricular ejection fraction (LVEF), measured with echocardiography, were also assessed and compared between the two groups.ResultsThe SAS, SDS, and POMS scores were lower in the MBSR intervention group than in the CR control group (P &lt; 0.05). There were also less IABP-related complications in the MBSR intervention group. LVEF was significantly improved in both groups, but the degree of LVEF improvement was more significant in the MBSR intervention group than in the CR control group (P &lt; 0.05).ConclusionsMBSR combined with early CR intervention can assist in alleviating anxiety, depression, and other negative mood states, reduce IABP-related complications, and further improve cardiac function in AMI patients with IABP assistance.
Case report: A fatal case of myocardial infarction due to myocardial bridge and concomitant vasospasm: the role of stress gated SPECT
Authors: Oh Seok , Hyun Dae Young , Cho Sang-Geon , Hong Young Joon , Kim Ju Han , Ahn Youngkeun , Jeong Myung Ho 
Published: May 2023

IntroductionAlthough most cases of myocardial bridge (MB) are clinically benign, sometimes it can be one of potential threats of myocardial infarction (MI) and life-threatening arrhythmia. In the present study, we present a case of ST-segment elevation MI caused by MB and concomitant vasospasm.Case PresentationA 52-year-old woman was brought to our tertiary hospital due to resuscitated cardiac arrest. Because the 12-lead electrocardiogram indicated ST-segment elevation MI, coronary angiogram was promptly commenced, which showed near-total occlusion at the middle portion of left anterior descending coronary artery (LAD). After intracoronary nitroglycerin administration, this occlusion was dramatically relieved, however, systolic compression at this site remained, indicative of myocardial bridge (MB). Intravascular ultrasound also showed eccentric compression with a “half-moon” sign, which is consistent with MB. Coronary computed tomography also showed a bridged coronary segment surrounded by myocardium at the middle portion of LAD. To assess the severity and extent of myocardial damages and ischemia, myocardial single photon emission computed tomography (SPECT) was additionally conducted, showing a moderate fixed perfusion defect around the cardiac apex, suggesting MI. After receiving optimal medical therapy, the patient's clinical symptoms and signs were improved then the patient was discharged from the hospital successfully and uneventfully.ConclusionWe demonstrated a case of MB-induced ST-segment elevation MI which was confirmed with its perfusion defects via myocardial perfusion SPECT. There have been proposed a number of diagnostic modalities to examine its anatomic and physiologic significance. Among them, myocardial perfusion SPECT can be available as one of useful modalities to evaluate the severity and extent of myocardial ischemia in patients with MB.
Oil and gas prediction basing on seismic inversion of elastic properties in Chaoshan depression, south China sea
Authors: Guangjian Zhong , Zhongquan Zhao , Guanghong Tu , Kangshou Zhang , Jing Zhao , Hai Yi , Changmao Feng , Junhui Yu 
Published: May 2023

The marine Mesozoic is widely distributed in the northeastern waters of the South China Sea and is an important field for oil-gas exploration in the South China Sea. The Chaoshan Depression is the largest residual depression in this sea. At a previous well, LF35-1-1, no oil and gas have been discovered with then pre-drilling prediction techniques. Post-drill analysis shows that the physical properties of the Mesozoic reservoir are not favorable there. So, in accurate prediction of the oil-gas reservoirs is necessary. Since the drilling at the LF35-1-1, extensive surveys and studies have been carried out which shows a number of favorable trapping structures. In the middle low bulge of the Chaoshan Depression, the DS-A structures found with potential reservoirs, complete trap structures, and dual source hydrocarbon supply on both sides, making it the most favorable zone for oil-gas accumulation. We apply the state of art prediction techniques for it using pre-stack seismic raw gather. The sensitivity analysis results of reservoir physical properties indicate that the difference in P- wave velocity between sand and mudstone is 500 m/s, the difference in density is 0.02 g/cm3, and the Poisson’s ratio ranges between 0.11 and 0.33. The Mesozoic sandstone reservoirs in the Chaoshan Depression have characteristics of high velocity and low Poisson’s ratio, and the P-wave velocity, density, and Poisson’s ratio are the main sensitive parameters for predicting reservoir and its oil-gas bearing properties. The density inversion, P-wave impedance inversion, and S-wave impedance inversion jointly characterize the “wedge-shaped” sand body in the DS-A structural area, with a maximum thickness of over 400 m and an area of ∼130 km2. The overlap of the sand body contour map and Poisson’s ratio inversion results indicates that the “wedge-shaped” sand body is an oil-gas bearing sand body. It can be concluded that pre-stack elastic parameter inversion is an effective method for reservoir prediction in deep-sea no-well exploration areas. It has the characteristics of high signal-to-noise ratio, strong stability and reliability, and high accuracy, which is conducive to reduce the non-uniqueness and uncertainty of seismic inversion. The inversion results predict that the DS-A structure is an oil-gas bearing structure.
The Kulbäcksliden Research Infrastructure: a unique setting for northern peatland studies
Authors: Noumonvi Koffi Dodji , Ågren Anneli M. , Ratcliffe Joshua L. , Öquist Mats G. , Ericson Lars , Tong Cheuk Hei Marcus , Järveoja Järvi , Zhu Wei , Osterwalder Stefan , Peng Haijun , Erefur Charlotta , Bishop Kevin , Laudon Hjalmar , Nilsson Mats B. , Peichl Matthias 
Published: May 2023

Boreal peatlands represent a biogeochemically unique and diverse environment in high-latitude landscape. They represent a long-term globally significant sink for carbon dioxide and a source of methane, hence playing an important role in regulating the global climate. There is an increasing interest in deciphering peatland biogeochemical processes to improve our understanding of how anthropogenic and climate change effects regulate the peatland biogeochemistry and greenhouse gas balances. At present, most studies investigating land-atmosphere exchanges of peatland ecosystems are commonly based on single-tower setups, which require the assumption of homogeneous conditions during upscaling to the landscape. However, the spatial organization of peatland complexes might feature large heterogeneity due to its varying underlying topography and vegetation composition. Little is known about how well single site studies represent the spatial variations of biogeochemical processes across entire peatland complexes. The recently established Kulbäcksliden Research Infrastructure (KRI) includes five peatland study sites located less than 3 km apart, thus providing a unique opportunity to explore the spatial variation in ecosystem-scale processes across a typical boreal peatland complex. All KRI sites are equipped with eddy covariance flux towers combined with installations for detailed monitoring of biotic and abiotic variables, as well as catchment-scale hydrology and hydrochemistry. Here, we review studies that were conducted in the Kulbäcksliden area and provide a description of the site characteristics as well as the instrumentation available at the KRI. We highlight the value of long-term infrastructures with ecosystem-scale and replicated experimental sites to advance our understanding of peatland biogeochemistry, hydrology, ecology, and its feedbacks on the environment and climate system.
Integration of nurse-led virtual reviews with growth hormone device-linked patient adherence information: a mixed methods feasibility study
Authors: Stokes Helen , Jones Julie , Worth Chris , Nicholson Jacqueline , Fullwood Catherine , Banerjee Indraneel 
Published: May 2023

IntroductionEasypod-connect™ for childhood growth disorders is a unique connected system that enables transmission of injection adherence information for recombinant human growth hormone (r-hGH). Although this system has the potential to facilitate greater adherence, observational studies have shown declining adherence over prolonged periods when used without additional support. Supplemental nurse practitioner support has been envisaged but not investigated; in this study, we have undertaken feasibility analysis of nurse-led virtual reviews (NVR) in combination with easypod-connect™ in a single centre using quantitative and qualitative analyses.AimsWe aimed to test feasibility by assessing compliance with NVR, height standard deviation score (SDS) gain, adherence improvement and patient opinions.MethodsPatients using easypod™ r-hGH were recruited prospectively to a 12-month study with two telephone NVR appointments in addition to standard of care in-person hospital outpatient visits. A subset was recruited for a semi-structured interview for qualitative thematic analysis.ResultsForty-three patients of median (range) age 10.7 (6.7, 15.2) were recruited for a period of 1.1 (0.7, 1.8) years. Thirty-three (76.7%) patients were fully compliant with NVR integration with easypod-connect™, establishing feasibility. Median (inter-quartile range, IQR) height SDS improved from -1.85 (-2.44, -1.37) to -1.48 (-2.14, -1.07) (p&lt;0.001) while adherence remained similar in the majority from study start [96.5 (88.8, 100.0)] to end [99.0 (94.0, 100.0)]. Qualitative analysis identified themes supporting patient benefit: practicalities of appointments, perceived purpose and significance of virtual reviews, and the importance of optimising growth. Four patients complained of injection pain, of whom two switched to an alternative r-hGH device.ConclusionOur study has demonstrated the feasibility of nurse-led virtual review integration with easypod-connect™ in a mixed methods study, laying the foundation for research in larger groups over longer periods. Nurse practitioner supported application of easypod-connect™ offers the potential for improved growth outcomes in all r-hGH devices providing adherence information.
Trends of the burden of type 2 diabetes mellitus attributable to high body mass index from 1990 to 2019 in China
Authors: Wang Jianglin , Zhou Lingyun , Yin Wenjun , Hu Can , Zuo Xiaocong 
Published: May 2023

BackgroundOverweight and obesity are well-known risk factors for developing type 2 diabetes (T2DM). However, details on the evolution of the T2DM burden attributed to China’s high body mass index (BMI) in China have not been thoroughly studied. This study aimed to investigate the temporal trends of the T2DM burden attributable to a high BMI in China from 1990 to 2019 and to evaluate the independent effects of age, period, and cohort on the burden of T2DM attributed to a high BMI.MethodsData on T2DM burden attributable to a high BMI from 1990 to 2019 were obtained from the Global Burden of Disease Study 2019. Deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of T2DM attributable to a high BMI were estimated by age and sex. The joinpoint regression model was performed to calculate the annual percentage change (APC) and the average annual percentage change (AAPC) in the burden of T2DM attributed to a high BMI. The age–period–cohort analysis was applied to estimate the independent effects of age, period, and cohort on the temporal trends of mortality and the DALY rate.ResultsIn 2019, deaths and DALYs from T2DM attributable to a high BMI in China were 47.53 thousand and 3.74 million, respectively, five times higher than in 1990. Among those under 60 years of age, men had higher deaths and DALYs than women, while the gender differences reversed in those over 60 years of age. Furthermore, the ASMR and ASDR in 2019 were 2.39 per 100,000 (95%UI 1.12–3.90) and 181.54 per 100,000 (95%UI 93.71–286.33), respectively, representing a 91% and 126% increase since 1990. In China, women previously had a higher ASMR and ASDR than men, while the differences in the ASMR and ASDR between the sexes were reversed in recent years. From 1990 to 2019, the ASMR in women increased before 2004 and then decreased from 2004 to 2015, and increased again after, with an overall AAPC value of 1.6%. In contrast, the ASMR in men continued to increase, with an overall AAPC value of 3.2%. The ASDR continued to increase in men and women, with AAPCs of 2.2% and 3.5%, respectively. The age effect showed that the relative risk of mortality increased with age in both men and women, except for the 75–84 age group. The impact of the age on the DALY rate revealed a trend of first rising and then decreasing, peaking at 65–69 years. The effect of the period on the burden of T2DM attributable to a high BMI increased from 1990 to 2019. The cohort effect generally showed a downward trend.ConclusionThe burden of T2DM attributed to a high BMI in China increased substantially from 1990 to 2019, particularly in men. Therefore, there is an urgent need for gender- and age-based public health guidelines on prevention strategies, early diagnosis, and effective management of T2DM, overweight, and obesity in China.
Wind tunnel test study on the wind load variation law of a point focus solar furnace
Authors: He Mingfei , Huang Penglin , Gong Bo , Zang Chuncheng , Wang Zhifeng 
Published: May 2023

This work studied the wind load acting on a point focus solar furnace composed of a 110 m2 heliostat and a 77 m2 concentrator through wind tunnel testing. Based on wind tunnel test data under 305 different working conditions, the variation laws of the wind pressure coefficient, power spectral density, and wind load coefficient of the heliostat and concentrator were analyzed. The results showed that due to the interaction between the concentrator and heliostat, the wind speed near the heliostat and concentrator decreased but the turbulence intensity increased, which caused the peak wind load coefficient to rise slightly. The results suggested that a safety factor of 1.1–1.2 should be considered for structural design and optimization of solar furnaces.
On the role of energy infrastructure in the energy transition. Case study of an energy independent and CO2 neutral energy system for Switzerland
Authors: Schnidrig Jonas , Cherkaoui Rachid , Calisesi Yasmine , Margni Manuele , Maréchal François 
Published: May 2023

The transition towards renewable energy is leading to an important strain on the energy grids. The question of designing and deploying renewable energy technologies in symbiosis with existing grids and infrastructure is arising. While current energy system models mainly focus on the energy transformation system or only investigate the effect on one energy vector grid, we present a methodology to characterize different energy vector grids and storage, integrated into the multi-energy and multi-sector modeling framework EnergyScope. The characterization of energy grids is achieved through a traditional energy technology and grid modeling approach, integrating economic and technical parameters. The methodology has been applied to the case study of a country with a high existing transmission infrastructure density, e.g., Switzerland, switching from a fossil fuel-based system to a high share of renewable energy deployment. The results show that the economic optimum with high shares of renewable energy requires the electric distribution grid reinforcement with 2.439 GW (+61%) Low Voltage (LV) and 4.626 GW (+82%) Medium Voltage (MV), with no reinforcement required at transmission level [High Voltage (HV) and Extra High Voltage (EHV)]. The reinforcement is due to high shares of LV-Photovoltaic (PV) (15.4 GW) and MV-wind (20 GW) deployment. Without reinforcement, additional biomass is required for methane production, which is stored in 4.8–5.95 TWh methane storage tanks to compensate for seasonal intermittency using the existing gas infrastructure. In contrast, hydro storage capacity is used at a maximum of 8.9 TWh. Furthermore, the choice of less efficient technologies to avoid reinforcement results in a 8.5%–9.3% cost penalty compared to the cost of the reinforced system. This study considers a geographically averaged and aggregated model, assuming all production and consumption are made in one single spot, not considering the role of future decentralization of the energy system, leading to a possible overestimation of grid reinforcement needs.
The application of clinical variable-based nomogram in predicting overall survival in malignant phyllodes tumors of the breast
Authors: Li Wei , Fang Kun , Chen Jiaren , Deng Jian , Li Dan , Cao Hong 
Published: May 2023

Background: We aimed to explore prognostic risk factors in patients with malignant phyllodes tumors (PTs) of the breast and construct a survival prediction model.Methods: The Surveillance, Epidemiology, and End Results database was used to collect information on patients with malignant breast PTs from 2004 to 2015. The patients were randomly divided into training and validation groups using R software. Univariate and multivariate Cox regression analyses were used to screen out independent risk factors. Then, a nomogram model was developed in the training group and validated in the validation group, and the prediction performance and concordance were evaluated.Results: The study included 508 patients with malignant PTs of the breast, including 356 in the training group and 152 in the validation group. Univariate and multivariate Cox proportional hazard regression analyses showed that age, tumor size, tumor stage, regional lymph node metastasis (N), distant metastasis (M) and tumor grade were independent risk factors for the 5-year survival rate of patients with breast PTs in the training group (p &lt; 0.05). These factors were used to construct the nomogram prediction model. The results showed that the C-indices of the training and validation groups were 0.845 (95% confidence interval [CI] 0.802–0.888) and 0.784 (95% CI 0.688–0.880), respectively. The calibration curves of the two groups were close to the ideal 45° reference line and showed good performance and concordance. Receiver operating characteristic and decision curve analysis curves showed that the nomogram has better predictive accuracy than other clinical factors.Conclusion: The nomogram prediction model constructed in this study has good predictive value. It can effectively assess the survival rates of patients with malignant breast PTs, which will aid in the personalized management and treatment of clinical patients.