bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the added value of intravenous gadolinium for knee osteosarcoma resection planning in pediatric and young adult patients
Authors: Thomas Nathan P. , Pierce Theodore T. , Ozturk Arinc , Lee Stella J. , Crawford Brooke , Hennessy David W. , Park Andrew , Sagar Pallavi , Heng Marilyn , Lozano Calderón Santiago 
Published: August 2023

AbstractBackground and ObjectivesTo assess the impact of Gadolinium‐enhanced magnetic resonance imaging (MRI) sequences on Preoperative imaging evaluation and surgical planning parameters for osteosarcoma (OS) of the knee in pediatric and young adult patients.MethodsThirty MRI scans of patients with OS about the knee were reviewed by five orthopedic oncologists. Key preoperative parameters (neurovascular bundle involvement, intra‐articular tumor extension, extent of intramedullary extension) and surgical plans were evaluated based on non‐contrast versus Gd contrast enhanced sequences. Assessment agreement, inter‐rater agreement, and intrarater agreement between pre and postcontrast images were evaluated via Kappa statistics.ResultsModerate agreement was seen between non and contrast‐enhanced assessment of neurovascular involvement and intra‐articular tumor extension. Intrarater reproducibility was substantial for neurovascular bundle involvement (precontrast Kappa: 0.63, postcontrast Kappa: 0.69). Intrarater reproducibility was also substantial for precontrast (Kappa: 0.70) and moderate for postcontrast (Kappa: 0.50) assessment of intra‐articular tumor extension. Planned resection length and choice of surgical approach were similar between sequences. The addition of Gd‐enhanced sequences improved the inter‐rater agreement across collected parameters.ConclusionsWhile some findings suggest that contrast enhanced sequences may not significantly alter the assessment of key preoperative planning parameters by orthopedic oncologists, they may help reduce variability among providers with differing experience levels.
Bio‐experienced psoriasis patients treated with anti‐interleukin monoclonal antibodies are less likely to achieve PASI 90, PASI 100, PASI ≤ 1 and ≤3: Results from a cohort of 305 patients
Authors: Margiotta Flavia Manzo , Michelucci Alessandra , Panduri Salvatore , Angeloni Laura , Fidanzi Cristian , Granieri Giammarco , Morganti Riccardo , Romanelli Marco , Dini Valentina 
Published: August 2023

AbstractBackgroundMonoclonal antibodies (mAbs) directed against tumour necrosis factor alpha (TNF‐α) and interleukin (IL)‐17 and ‐23 represent the ultimate therapeutic strategy in treating psoriasis patients, but scientific literature still does not provide conclusive results regarding the possible influence of previous biological therapies on real‐life therapeutic response.ObjectivesThe objective of our work was to investigate any putative difference in the achievement and maintenance of PASI 75, 90 and 100, as well as the probability to achieve absolute PASI ≤ 1 and ≤3, between 305 bio‐naïve and bio‐experienced patients treated with anti‐IL mAbs.MethodsA comparison between previous biologic and clinical factors, including relative and absolute PASI, was carried out through chi square test. Survival curves for the achievement of PASI 75, 90 and 100 and their differences were evaluated, performing a multivariate analysis (confidence interval 95%; p < 0.0.5).ResultsPrevious biologic therapy resulted associated with a lower rate of PASI 75 (hazard ratio [HR]: 1339; p = 0.034), 90 (HR: 1365; p = 0.0031) and 100 achievement (HR 1596; p = 0,007). The survival curves showed how bio‐experienced patients were less likely to reach and maintain PASI 90 (naïve vs. anti‐IL: p = 0.001; naïve vs. anti‐TNF + anti‐IL: p < 0.001) and PASI 100 (naïve vs. anti‐TNF‐α: p = 0.014; naïve vs. anti‐IL: p < 0.001; naïve vs. anti‐TNF‐α + anti‐IL: p < 0.001). Moreover, bio‐naïve patients showed a greater probability to achieve both absolute PASI ≤ 3 and ≤1 (p < 0.001).ConclusionsOur results represent a real‐life analysis on the impact of previous biologic therapy in the clinical efficacy of anti‐IL. Even if further studies with bigger samples are needed to extrapolate absolute considerations, we provided the first evidence on the burden of the bio‐naïve condition for a greater achievement of both PASI 90, 100 and the probability to achieve PASI ≤ 1 and ≤3.
Drivers behind the diversity and distribution of a widespread midwater narcomedusa
Authors: Verhaegen Gerlien , Sangekar Mehul Naresh , Bentlage Bastian , Hoving Henk‐Jan , Collins Allen G. , Lindsay Dhugal 
Published: August 2023

AbstractNarcomedusae play a key role as top‐down regulators in the midwater, the largest and most understudied biome on Earth. Here, we used ecological niche modeling in three‐dimensions (3D), ecomorphology, and phylogeny, to answer evolutionary and ecological questions about the widespread narcomedusan genus Solmissus. Our phylogenetic analyses confirmed that Solmissus incisa represents a complex of several cryptic species. Both the different genetic clades and tentacle morphotypes were widespread and often overlapped geographically‐ the main difference in their distribution and ecological niche being depth. This demonstrated the importance of including the third dimension when modeling the distribution of pelagic species. Contrary to our hypothesis, we found the modeled distribution of the Solmissus genus (n = 1444) and both tentacle morphotypes to be mostly driven by low dissolved oxygen values and a salinity of 34, and slightly by depth and temperature. Solmissus spp. were reproducing all year round, with specimens reproducing in slightly warmer waters (up to 1.25°C warmer). Our results suggest that Solmissus spp. will likely come out as climate change winners by expanding their distribution when facing ocean deoxygenation and by increasing their reproduction due to global warming. However, because most available midwater data comes from the northern Pacific, this sampling bias was undoubtedly reflected in the output of our ecological niche models, which should be assessed carefully. Our study illustrated the value of online databases including imagery and videography records, for studying midwater organisms and treating midwater biogeographic regions as 3D spaces.
Novel interpolation spaces and maximal‐weighted Hölder regularity results for the fractional abstract Cauchy problem
Authors: Chen Yuting , Fan Zhenbin 
Published: August 2023

AbstractIn this paper, the maximal‐weighted Hölder regularity for the fractional abstract Cauchy problem is presented. First, two classes of novel interpolation spaces constructed by resolvent families are portrayed. Afterward, by applying the resolvent method and the properties of interpolation spaces, the maximal‐weighted Hölder regularity of the mild solution is established in weighted Hölder space (, ). Eventually, an instance for the fractional differential equation of 2m‐order multidimensional parabolic type is provided to verify the reasonability of main conclusions.
Environmental productivity assessment: An illustration with the Ecuadorian oil industry
Authors: Abad Arnaud , Arias Michell , Ravelojaona Paola 
Published: August 2023

AbstractThis paper assesses the performance of 20 Ecuadorian petroleum industry over the period 2014–2018, using the pollution‐adjusted Malmquist (PM) and Hicks–Moorsteen (PHM) productivity indices within a convex neutral analytical framework. Indeed, to the best of our knowledge, the environmental performance variation of the Ecuadorian oil industry has never been investigated hitherto in the literature. Moreover, the existing literature that analyses the environmental performance change of oil industries applied the Malmquist productivity index by considering a convex production set. However, the convexity assumption results in ignoring possible non‐linearities in the production process. Also, the performed PM and PHM in this paper are decomposed and disaggregated to provide the main drivers of both economic and polluting productivity change. Finally, the performance change assessment is carried out through a nonparametric enumerative method that is defined in the paper.
A 148–170‐GHz 4‐bit variable gain amplifier with stagger‐tuning and multistage‐phase‐compensation techniques in 0.13‐μm SiGe
Authors: Yang Maoxuan , Zhang Zhenyi , Xie Qian , Wang Zheng 
Published: August 2023

AbstractThis letter presents a 148–170‐GHz 4‐bit variable gain amplifier (VGA) with stagger‐tuning and multistage‐phase‐compensation techniques. In the design of this proposed VGA, phase variation is minimized by cascading overcompensation VGA and undercompensation VGA with reverse gain‐phase characteristics and phase suppression characteristics at sideband, achieved through different shunt inductors to ground. Additionally, stagger‐tuning technique has been introduced to realize VGA design. To prove these techniques, a 148–170‐GHz 4‐bit VGA has been fabricated in 0.13‐μm SiGe bipolar complementary metal‐oxide‐semiconductor (350/450 GHz ft/fmax) with a compact size of . The results show the VGA achieves phase variation and over 10‐dB tuning range with 0.6‐dB gain step for a wide operating frequency from 148 to 170 GHz. The RMS gain error is  dB, the simulated input is  dBm and the total power consumption is 32.4‐mW with 2.25 V supply voltage.
Integrated analysis of the transcriptome and its interaction with the metabolome in metabolic associated fatty liver disease: Gut microbiome signatures, correlation networks, and effect of PNPLA3 genotype
Authors: Mascardi María Florencia , Mazzini Flavia Noelia , Suárez Bárbara , Ruda Vera M. , Marciano Sebastián , Casciato Paola , Narvaez Adrián , Haddad Leila , Anders Margarita , Orozco Federico , Tamaroff Ana Jesica , Cook Frank , Gounarides John , Gutt Susana , Gadano Adrián , García Celia Méndez , Marro Martin L. , Penas Steinhardt Alberto , Trinks Julieta 
Published: August 2023

AbstractInteractions between communities of the gut microbiome and with the host could affect the onset and progression of metabolic associated fatty liver disease (MAFLD), and can be useful as new diagnostic and prognostic biomarkers. In this study, we performed a multi‐omics approach to unravel gut microbiome signatures from 32 biopsy‐proven patients (10 simple steatosis ‐SS‐ and 22 steatohepatitis ‐SH‐) and 19 healthy volunteers (HV). Human and microbial transcripts were differentially identified between groups (MAFLD vs. HV/SH vs. SS), and analyzed for weighted correlation networks together with previously detected metabolites from the same set of samples. We observed that expression of Desulfobacteraceae bacterium, methanogenic archaea, Mushu phage, opportunistic pathogenic fungi Fusarium proliferatum and Candida sorbophila, protozoa Blastocystis spp. and Fonticula alba were upregulated in MAFLD and SH. Desulfobacteraceae bacterium and Mushu phage were hub species in the onset of MAFLD, whereas the activity of Fonticula alba, Faecalibacterium prausnitzii, and Mushu phage act as key regulators of the progression to SH. A combination of clinical, metabolomic, and transcriptomic parameters showed the highest predictive capacity for MAFLD and SH (AUC = 0.96). In conclusion, faecal microbiome markers from several community members contribute to the switch in signatures characteristic of MAFLD and its progression towards SH.
Charge localization in bis(dioxaborine) radical anions
Authors: Moneo Álvaro , Carvalho M. Fernanda N. N. , Telo João P. 
Published: August 2023

AbstractThe mixed valence (MV) radical anions of several bis(dioxaborines) with aromatic bridges of different length were studied by Vis/NIR spectroscopy, cyclic voltammetry, and theoretical calculations. The phenyl‐bridged (1), the biphenyl‐bridged (2), and bithiophene‐bridged (5) radical anions show intense low‐energy intervalence bands with vibrational structure typical of charge delocalized mixed valence species in the range of solvents studied. However, by subtracting from the experimental spectra of 2− in MeCN the fraction corresponding to the delocalized part (taken as the spectrum in tetrahydrofuran [THF]), we get a localized charge‐transfer bands that show a significant cutoff effect at the low‐energy side, as predicted by classical Marcus–Hush theory. In the radical anions with three aromatic rings on the bridge, the localization of the charge changes with solvent. These radicals are predominantly charge‐localized in the high λS solvent MeCN, charge‐delocalized in the low λS solvent THF, and show both type of intervalence bands in DMF. Experimental results and theoretical calculations show that the electronic coupling between dioxaborine units in these three‐ring bridged radical anions increases with the number of thiophene rings on the bridge.
Could cannabinoids provide a new hope for ovarian cancer patients?
Authors: Kaur Rimanee , Javid Farideh A. 
Published: August 2023

AbstractIt is known that gynecological cancers remain a worldwide problem and as shown by the statistics, there is a need for new gynecological cancer treatments. Cannabinoids, the pharmacologically active compounds of the Cannabis sativa plant, have been used for many centuries by individuals as a symptomatic treatment to alleviate pain, nausea, vomiting, and to help stimulate appetite. Research has revealed that cannabinoids also exert anti‐cancer activity such as anti‐proliferative and pro‐apoptotic effects through a variety of mechanisms. There is significant value in the development of these compounds as anti‐cancer therapies in clinical practice as they do not produce the typical toxic side effects that exist with conventional therapies and recent clinical trials have shown their great tolerability by patients at high doses. Cannabinoids can induce psychoactive effects that could limit their progression. Therefore, non‐psychoactive cannabinoids are attracting pharmacological interest due to their inability to produce psychological effects. Recent studies have focussed on non‐psychoactive cannabinoids in ovarian cancer and have revealed promising pre‐clinical results that indicate that these compounds may have potential benefits in the treatment of these cancers. However, there are still unanswered questions and research gaps that need to be addressed. This review summarizes the current understanding of this topic and identifies the current gaps in knowledge that provide a useful direction for future work.
Rabies experts on demand: A cross‐sectional study describing the use of a rabies telehealth service
Authors: Baker Sarah E. , Ross Yasmeen B. , Ellison James A. , Monroe Benjamin P. , Orciari Lillian A. , Petersen Brett W. , Rao Agam K. , Wallace Ryan M. 
Published: August 2023

AbstractBackgroundRabies expert on demand (REOD) telehealth service is provided by the U.S. Centers for Disease Control and Prevention (CDC) to assist public health practitioners, health providers, and the public to interpret national and international rabies prevention guidelines. REOD is staffed by subject matter experts of the CDC Poxvirus and Rabies Branch to assess each unique situation and provide evidence‐based guidance to stakeholders. This study aims to describe the utilization of a rabies telehealth system and provide insight into common consultations.MethodsA cross‐sectional study of the nature of inquiries to REOD was done using the data collected from September 1, 2017 to September 30, 2021. An inquiry tracking form and Microsoft Access database were developed to document all inquiries received. Inquired ones were summarized to determine the frequency of inquiries by month, category, and location.ResultsOver a 49‐month period, REOD received 5228 inquiries. Peak inquiries (n = 108) occurred during August 2019. The most frequent inquiries received pertained to risk assessment and management of rabies exposures (n = 1109), requests for testing assistance (n = 912), consultation for suspected human rabies (n = 746), rabies exposures and post‐bite treatment occurring internationally (n = 310), and consultation for deviations in the recommended pre‐ and postexposure prophylaxis regimen (n = 300).ConclusionREOD is a global resource for consultation related to managing rabies exposures, diagnostic issues, and rabies control strategies. REOD is a regularly utilized CDC service, as the demand for up‐to‐date rabies guidance remains high. REOD fulfills a critical role for the interpretation and consultation on rabies prevention guidelines to stakeholder.
The impact of globalization on the decoupling of water consumption and economic growth in BRICS and N11 countries—Linear and nonlinear approaches
Authors: Wang Qiang , Wang Xiaowei , Li Rongrong 
Published: August 2023

AbstractIn the context of globalization, the 2030 sustainable development goals pose a huge challenge to the coordinated development of economy and environment in emerging economies. The purpose of this article is to investigate whether globalization contributes to balance water consumption and economic growth in emerging economies. China is the largest developing country and the largest trader of goods in the world. From holistic and representative perspectives, this article analyzes the mechanisms affecting economic growth and water consumption in BRICS countries, Next Eleven (N11) countries and China. Combining decoupling model and econometric models, fully modified ordinary least squares (FMOLS) linear model and threshold panel nonlinear model are constructed. Both linear and nonlinear effects of trade and foreign investment on economic growth and water consumption are considered. The results show that, from a holistic perspective, globalization helps balance economic growth and water consumption in emerging economies. The impact of trade on water consumption in BRICS countries is negative. And with the increase of trade, its positive coefficient on water consumption in N11 countries gradually decreases. Foreign direct investment (FDI) plays a positive role in the coordinated development of economic growth and water environment in BRICS and N11 countries. Taking China as a representative country, there is a decoupling phenomenon between economic growth and water use during the study period. With the trade crossing the threshold successively, the promoting effect on economy increases first and then decreases, and the inhibiting effect on water consumption weakens. With the increase of foreign investment, its positive effect on GDP increases, and its positive coefficient on water consumption decreases. The conclusions from representative country and holistic perspective are consistent. Finally, some policy recommendations are put forward.
Extremely Large Response of Phonon Coherence in Twisted Penta‐NiN2 Bilayer
Authors: Zhang Chenxin , Sun Jie , Shen Yiheng , Zhang Cunzhi , Wang Qian , Yoshikawa Akira , Kawazoe Yoshiyuki , Jena Puru 
Published: August 2023

AbstractTwisting has recently been demonstrated as an effective strategy for tuning the interactions between particles or quasi‐particles in layered materials. Motivated by the recent experimental synthesis of pentagonal NiN2 sheet [ACS Nano 2021, 15, 13539], for the first time, the response of phonon coherence to twisting in bilayer penta‐NiN2, going beyond the particle‐like phonon transport is studied. By using the unified theory of phonon transport and high order lattice anharmonicity, together with the self‐consistent phonon theory, it is found that the lattice thermal conductivity is reduced by 80.6% from 33.35 to 6.47 W m−1 K−1 at 300 K when the layers are twisted. In particular, the contribution of phonon coherence is increased sharply by an order of magnitude, from 0.21 to 2.40 W m−1 K−1 , due to the reduced differences between the phonon frequencies and enhanced anharmonicity after the introduction of twist. The work provides a fundamental understanding of the phonon interaction in twisted pentagonal sheets.
Repeating the Listening Text: Effects on Listener Performance, Metacognitive Strategy Use, and Anxiety
Authors: Holzknecht Franz , Harding Luke 
Published: August 2023

AbstractIn second language listening assessment and pedagogy, practitioners hold different views on whether to repeat a listening text in contexts where inferences about listening ability are to be drawn from task performance. To address this issue, we investigated the effects of repeating the listening text (double play) on listener performance, listening strategies, test‐taking strategies, test‐taking anxiety, and listening anxiety. Three hundred six Austrian secondary school students responded to four listening tasks drawn from the Austrian Matura exam and completed questionnaires measuring strategic behavior and anxiety in a counter‐balanced research design. Data were analyzed using many‐facet Rasch measurement (MFRM), factor analysis, and inferential statistics. Findings confirmed that double play led to higher levels of listener performance across two task types (multiple‐choice items and note completion), however, scores were higher in the single play condition compared to the first play of double play. Students also reported lower levels of anxiety, and the use of more listening strategies and fewer test‐taking strategies in double play compared to single play with small effect sizes. We discuss the importance of balancing an empirically derived understanding of the effects of repeating the listening text with considerations of the purpose of an assessment, and the characteristics of the target language use domain.
Water security, participatory governance, and dialogue spaces for change in Northern Sri Lanka
Authors: Sriskandarajah Nadarajah , Sivapalan Murugesu 
Published: August 2023

AbstractWater Security through Participatory Action Research in the Northern Province (WASPAR) is a project driven by the University of Jaffna, Sri Lanka, since March 2020. The project itself and some of the significant outcomes over the 3‐year first phase of research are outlined here. WASPAR took inspiration from two emerging fields of study: Sociohydrology and Environmental Communication. Socio‐hydrology is envisaged as a science underpinning water governance, which engages with changes in both hydrology and society, not one or the other. Environmental Communication applied here works on the premise that how well we communicated with each other about water determined how well we addressed the ecological crisis. Communicating is synonymous to learning across multiple perspectives held by the many actors, often actors with competing interests and conflicting values. WASPAR acknowledged the limitations of existing institutional and social structures and their fragmented ways of water management. Instead, it put forward the search for a holistic, trans‐disciplinary, and multistakeholder approach for water security. Work to date on the project presented here reflect quantitative data gathered through empirical research within the project and in the field. Reflective analysis of qualitative data obtained from the participatory research processes are to be published later. Altogether, WASPAR project has made preliminary but promising steps in progressing towards informing, influencing and educating stakeholders, domain experts and decision‐makers on the need for and merits of participatory decision‐making, generating a sense of community, and the development of institutional infrastructure. Continuation of these efforts with increased participation of the research community in the universities during the next phase of this project needs to foster the governance approach and ensure the legitimacy and influence of the Northern Water Dialogue Forum in place for planning a water secure future for the Province.