bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘I no longer know that person’: Experiences of families living with someone using crystal methamphetamine
Authors: Sampson Dara , Heinsch Milena , Geddes Jenny , Velleman Richard , Velleman Gill , Teesson Maree , Newton Nicola , Kay-Lambkin Frances 
Published: April 2023

Background
Crystal methamphetamine (‘ice’) use is a large and growing worldwide problem, yet few research studies have explored the impact of crystal methamphetamine use on affected friends and family members. We explored the experiences and narratives of family members and friends of people who use methamphetamine to inform the development of a Family and Friend Support Program.

Methods
This paper reports on a subset of findings from a mixed method study, which sought to better understand the experiences of family members and friends of people who use methamphetamine. Participants were recruited via Facebook advertising and asked to complete a survey outlining their experiences. At the end of the survey, participants were invited to be interviewed by a clinical psychologist on the research team, to discuss their experiences in greater depth; seventeen people agreed to be interviewed. This paper is based on a qualitative thematic analysis of these interviews using Braun and Clarke’s 6-stage approach to identify key areas of concern for friends and family members of people who use methamphetamine.

Results
Through thematic analysis, five key themes were developed, namely: (1) loss, (2) stigma, (3) support (or lack thereof), (4) ways of coping, and (5) the value in sharing personal experiences. The results of this study revealed the profound sadness, frustration and loss friends and family members experienced when caring for a loved one who uses methamphetamine. This loss was further complicated by societal stigma surrounding the use of methamphetamine, which often extended to friends and family members themselves. Since experiences of grief and loss were interwoven across the three themes, concepts of ambiguous loss, disenfranchised grief, and narrative constructivist approaches to understanding loss, were applied to the discussion of results.

Conclusion
This study provides a more complete picture of family and caregiver experiences when caring for a loved one using methamphetamine, which may further help inform the design of intervention programs. Implications for future research and practice with this population are considered.
Influence of interphase characteristics on the elastic modulus of unidirectional glass-reinforced epoxy composites: a computational micromechanics study
Authors: Shubham  , Prusty Rajesh Kumar , Ray Bankim Chandra 
Published: April 2023

Abstract
This article briefly discusses the role of interphase in the elastic moduli of unidirectional fiber-reinforced polymer composite materials. For this unidirectional glass fiber was chosen as reinforcement, and epoxy was selected as the matrix. A hexagonally packed representative volume element is used for the micromechanical analysis. Experimental validation was initially used to verify the accuracy of the established equations of the rule of mixing, Composite Cylinder Assemblage, Chamis, Halpin and Tsai, and Puck. The Chamis equation was found to be the most reasonable. Then the finite element approach in which interphase has been included was used to estimate the elastic moduli. The finite element model without interphase and the experimental result were taken as a reference. The influence of interface ratio and property of interphase on the homogenised elastic properties of the unidirectional fiber-reinforced polymer composites is analysed. A micromechanics plugin in Abaqus software was used to estimate the density and Young’s modulus of the unidirectional fiber-reinforced polymer composites. The interphase properties are varied, having 6.25%, 12.5%, 25% and 50% influence of the fiber phase and the remaining influence of the matrix phase with interface ratios of 0.1, 0.2 and 0.3. The interface ratio of 0.3, having 6.25% fiber phase influence, gave the most reasonable moduli values (with an error <10%) compared to the mean experimental moduli. The study showed interface ratio and interphase properties to critically influence the overall elastic property of the unidirectional fiber-reinforced polymer composites.
Adopting online flipped teaching to improve learner engagement in an English for specific purposes (ESP) course in China: a mixed-methods study
Authors: Li Zhiyong , Wang Yang 
Published: April 2023

Abstract
In this study, we evaluated the effect of online flipped teaching on learner engagement in an English for specific purposes (ESP) listening and speaking course at a Chinese university. We also aimed to understand the factors influencing learner engagement in an online environment. For this study, an e-learning platform called Yunbanke was used for asynchronous teaching in a flipped class, and Tencent Meeting was employed for synchronous teaching in the non-flipped and flipped class, respectively. We used a mixed-methods approach. First, we conducted a quasi-experiment to compare engagement levels between the experimental group (flipped class, n = 34) and control group (non-flipped class, n = 35) before and after 16 weeks of online instruction. Then, we used lesson logs and conducted interviews with the students and the instructor. The results showed that online flipped teaching could significantly improve the learners’ behavioural and cognitive engagement compared to the non-flipped class. However, no significant difference was found in emotional engagement between the two classes. Qualitative data supported our quantitative findings, and five key factors leading to different dimensions of learner engagement were identified: learners’ prior English attainment, learners’ perceived affordance of online learning and teaching, interpersonal factors, instructor presence and learning tasks. Our findings can shed light on online ESP learners’ engagement and improve online ESP teaching practices.
Jacobsen syndrome: Chromosome deletion at llq23
Authors: Clang Daniel R. , LaBaere II Richard J. 
Published: April 2023

Abstract
A male infant delivered at term to unrelated parents was found to have multiple dysmorphic facial characteristics, abnormal head shape, anemia, thrombocytopenia, a prominent holosystolic heart murmur with multiple cardiac defects, hypotonia, and was small for his gestational age. Karotype revealed a de novo deletion of the long arm of chromosome 11, del (11 )(q23), which has been previously described as Jacobsen syndrome. Recent studies have demonstrated that a folate-sensitive fragile site at 11q, band 23, (1lq23) may be responsible for this deletion and possibly other syndromes as well.
Corrosion fatigue behavior of AA 7020 alloy in seawater
Authors: Yurdgulu Halil Ibrahim , Sadeler Recep , Yilmaz Hasan , Koc Baris 
Published: April 2023

Abstract
The effect of two-step aging treatment on the fatigue behavior of welded AA 7020 Al. alloy was investigated. For fatigue tests to be carried out in atmospheric and seawater environments, a plane bending tester at a stress ratio of R = 0 was used. Experiments in the control group were carried out with unwelded specimens at a strain rate of R = −1 in air. The gradual heat treatment, two-step aging, significantly improved the fatigue and corrosion fatigue behavior of welded AA 7020 alloys. Unwelded specimens showed better fatigue properties than the welded ones. In the experiments in the seawater environment, pitting, and exfoliation corrosion occurred on the surfaces. It was determined that the corrosion pits reduce the fatigue life of welded and unwelded specimens. It was also observed that the corrosion sensitivity of the welded specimens increased in the heat affected zone and resulted in corrosion fatigue cracking.
Synthesis of SnO2 nanoparticles coated ZnO–g–C3N4 composite nanostructures with novel antibacterial activity
Authors: Hussain Shah Muhammad Baqar , Mansoor Qaisar , Jan Tariq , Farooq Zahid , Ilyas Syed Zafar 
Published: April 2023

Abstract
In this work, composite nanostructures (CNs) of SnO2–ZnO–g–C3N4 have been prepared by a soft chemical method and investigated for their potential application in photocatalytic remediation of organics in water and antibacterial agents. Structural study revealed the presence of three phases related to hexagonal wurtzite phase of ZnO, tetragonal phase of SnO2 and monoclinic phase of g–C3N4 having nanocrystalline nature which confirms the formation of CNs. Formation of nanoscale morphology along with elemental composition of the CNs have been validated through scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) spectroscopy. The presence of only A
1g mode of SnO2 in Raman spectrum of ternary CNs suggested that SnO2 nanoparticles have been coated on the surfaces of ZnO and g–C3N4 which is also evident from SEM results. SnO2–ZnO–g–C3N4 CNs have shown much higher photocatalytic degradation efficiency and produced 7 mm greater zone of inhibition (ZOI) against Gram-positive S. Aureus bacteria as compared to pure ZnO which is quite significant result when compared to previously reported results for SnO2–ZnO CNs. These synthesized CNs may have potential uses in healthcare technology and treatment of organics in water.
Intrinsic neural timescales in the temporal lobe support an auditory processing hierarchy
Authors: Cusinato Riccardo , Alnes Sigurd L. , van Maren Ellen , Boccalaro Ida , Ledergerber Debora , Adamantidis Antoine , Imbach Lukas L. , Schindler Kaspar , Baud Maxime O. , Tzovara Athina 
Published: April 2023

During rest, intrinsic neural dynamics manifest at multiple timescales, which progressively increase along visual and somatosensory hierarchies. Theoretically, intrinsic timescales are thought to facilitate processing of external stimuli at multiple stages. However, direct links between timescales at rest and sensory processing, as well as translation to the auditory system are lacking. Here, we measured intracranial electroencephalography in 11 human patients with epilepsy (4 women), while listening to pure tones. We show that in the auditory network, intrinsic neural timescales progressively increase, while the spectral exponent flattens, from temporal to entorhinal cortex, hippocampus, and amygdala. Within the neocortex, intrinsic timescales exhibit spatial gradients that follow the temporal lobe anatomy. Crucially, intrinsic timescales at baseline can explain the latency of auditory responses: as intrinsic timescales increase, so do the single-electrode response onset and peak latencies. Our results suggest that the human auditory network exhibits a repertoire of intrinsic neural dynamics, which manifest in cortical gradients with millimeter resolution and may provide a variety of temporal windows to support auditory processing.SIGNIFICANCE STATEMENT:Endogenous neural dynamics are often characterized by their intrinsic timescales. These are thought to facilitate processing of external stimuli. However, a direct link between intrinsic timing at rest and sensory processing is missing. Here, with intracranial electroencephalography (iEEG), we show that intrinsic timescales progressively increase from temporal to entorhinal cortex, hippocampus, and amygdala. Intrinsic timescales at baseline can explain the variability in the timing of iEEG responses to sounds: cortical electrodes with fast timescales also show fast and short-lasting responses to auditory stimuli, which progressively increase in the hippocampus and amygdala. Our results suggest that a hierarchy of neural dynamics in the temporal lobe manifests across cortical and limbic structures and can explain the temporal richness of auditory responses.
On indications for repeat liver transplantation
Authors: Borovik V. V. , Tileubergenov I. I. , Gerasimova O. A. , Granov D. A. 
Published: April 2023

Objective: to study the causes of graft loss and indications for repeat liver transplantation (rLT).Materials and Methods. We studied the experience garnered from 250 orthotopic full-size cadaveric liver transplantations in 228 patients from 1998 to 2021. The severity of the patient’s condition at the time of intervention was estimated according to the MELD scale. Repeat surgeries were performed in 22 cases in 19 patients (analyzed group).Results. Organ preservation parameters, length of stay in intensive care unit (ICU), severity of postoperative complications in primary transplantations in general and in the analyzed group did not differ significantly. The main causes of graft loss were graft arterial insufficiency (57.9%) and hepatic artery thrombosis (21%). Severe early allograft dysfunction (EAD) and primary nonfunction accounted for 10.5%, portal vein thrombosis occurred in 5%, and chronic graft rejection was noted in 5% of cases.Conclusion. Arterial insufficiency is one of the leading causes of graft loss after liver transplantation. Early correction of arterial and biliary complications help in preserving graft viability.
Personalized dosing protocol for extended-release tacrolimus in kidney transplant recipients in the early postoperative period
Authors: Shabunin A. V. , Drozdov P. A. , Makeev D. A. , Nesterenko I. V. , Zhuravel O. S. , Karapetyan L. R. , Astapovich S. A. , Lidzhieva Е. A. 
Published: April 2023

Objective: to develop a personalized algorithm for extended-release tacrolimus in kidney recipients and to analyze its early outcomes in comparison with a retrospective control group.Materials and methods. The first (I) control group «Standard Protocol» included 228 patients operated on at Botkin City Clinical Hospital from June 2018 to November 2021; tacrolimus was administered postoperatively in a starting standard dosage of 0.2 mg/kg. The second group (II) consisted of 75 patients operated from December 2021 to November 2022, whose postoperative treatment involved a personalized extended-release tacrolimus dosing protocol. Induction immunosuppression was similar in both groups. The target tacrolimus level in the early postoperative period was considered to be 10-12 ng/ml for all patients. The comparison criteria included incidence of Over-immunosuppression (tacrolimus C0 >15 ng/ml), incidence of acute rejection and infectious complications in the first month after surgery, incidence and duration of delayed graft function (DGF), and length of stay at the hospital.Results. Over-immunosuppression was statistically significantly lower in the personalized protocol group, with 36.7% in group I and 87.5% in group II (p < 0.001). There was also a lower incidence of early infectious complications in group II: 5.4% vs. 13.2%, however, without reaching a level of statistical significance (p = 0.088). DGF incidence in group I and group II were 25.4% (58/228) and 22.7% (17/75), respectively. The length of stay at the hospital in group II was also statistically significantly lower: 13 versus 19 bed days (p = 0.033). In both subgroups, no patient developed acute rejection in the first month after surgery (p = 1).Conclusion. The personalized dosing protocol that was developed for extended-release tacrolimus in kidney recipients achieves the target levels of the drug recommended for the early postoperative period with low risk of under-immunosuppression and associated acute graft rejection, with a significantly lower incidence of over-immunosuppression.
Assessment of the quality of life of organ reoipients based on the results of the First Russian transplant games
Authors: Shelekhova T. Yu. , Achkasov E. E. , Lazareva I. A. , Krumkacheva Yu. A. , Sungatulina A. A. , Gautier S. V. 
Published: April 2023

Objective: to evaluate the role of physical activity (at sports games) in improving the quality of life of organ recipients.Materials and methods. We examined 42 adult lung, heart, kidney and liver recipients, and patients undergoing renal replacement therapy (mean age 42.6 ± 12.09 years) - participants of the First Russian Transplant Games. The results were analyzed. Quality of life of the recipients was assessed using the nonspecific SF-36 questionnaire.Results. After solid organ transplantation, the interviewed recipients answered that they try to lead an active lifestyle, to engage in accessible physical activities, and to participate in sports events intended for organ recipients. Assessment of the quality of life according to the SF-36 questionnaire showed that all the participants had high scores in terms of the physical and psychological component, which is associated with regular physical training and sports. Conclusion. Physical exercise and active participation in sports activities are an important component in the socialization and rehabilitation of organ recipients. These two factors also improve the psychological and physical components of the quality of life of the recipients.
Nonselective beta-blockers in primary prophylaxis of esophageal variceal bleeding in patients with ascites waitlisted for liver transplantation
Authors: Korobka V. L. , Pasechnikov V. D. , Korobka R. V. , Pak E. S. , Shapovalov A. M. , Pasechnikov D. V. 
Published: April 2023

Objective: to determine the efficacy of non-selective beta-blockers (NSBBs) in the primary prevention of bleeding esophageal varices and to assess their impact on the survival of patients with ascites enrolled in the liver transplant waiting list (LTWL).Materials and methods. We carried out a retrospective comparative study of cirrhotic patients with severe ascites and esophageal varices without bleeding before enrollment in the LTWL. Primary prophylaxis of variceal bleeding included the use of NSBBs (n = 97, group 1). These drugs were not used in the other patients (n = 91, group 2).Results. There were no significant differences between the groups in terms of clinical, laboratory and demographic parameters, MELD scores and Child-Turcotte-Pugh (CTP) classes for cirrhosis. Patient groups included in the study had no significant differences with respect to incidence of medium- and large-sized varices and incidence of severe ascites. Bleeding incidence was significantly lower in the NSBBs group than in the non-NSBBs group (52.6% and 95.6%, respectively, p = 0.0001).Conclusion. NSBBs constitute an efficacious therapy in primary prophylaxis of esophageal variceal bleeding, thereby saving life and preventing delisting of patients with ascites from the LTWL.
Experience in the use of neutralizing monoclonal antibodies in kidney transplant recipients with COVID-19
Authors: Kim I. G. , Lysenko M. A. , Frolova N. F. , Artyukhina L. Yu. , Buruleva T. A. , Nikitina A. M. , Vinogradov V. E. , Volodina E. V. , Chervinko V. I. , Kryukov E. V. , Zubkin M. L. 
Published: April 2023

Therapy with neutralizing monoclonal antibodies (mAbs) is particularly relevant during COVID-19 outbreaks in patients at high risk of severe disease, including kidney transplant recipients (KTRs).Objective: to evaluate the efficacy and safety of neutralizing mAbs in KTRs with mild to moderate COVID-19.Materials and methods. The retrospective study included 99 KTRs who received inpatient treatment for COVID-19 between September 1 and December 31, 2021. Patients were 52.0 ± 11.5 years old (M, 47.5%). Bamlanivimab/etesevimab combination drug at a dose of 700/1400 mg was used as mAbs. To evaluate the efficacy of mAbs therapy, two groups of patients were identified. Group 1 consisted of 33 KTRs who received mAbs as one of the therapy components, while group 2 consisted of 66 patients who received no mAbs. Discharge from the hospital or death was considered as the endpoint of follow-up.Results. In group 1, after the use of mAb, progression of pulmonary process was observed less frequently than in the control group with CT1-2 transformation to CT3-4 (9.1% vs. 30.3%, respectively, p < 0.01). Group 1 KTRs differed significantly from group 2 - lower need for ICU and ventilator care (6.1% vs. 27.3% and 3% vs. 19.8%, respectively). The groups were comparable by sex, age, body mass index, Charlson Comorbidity Index (CCI) and time after kidney transplant (KTx) at the onset of the disease and by rnseline blood biochemistry parameter values at the time of hospitalization. Only C-reactive protein (CRP) and fibrinogen values were higher in the non-mAbs patients who were hospitalized later in the course of the disease (7.7 ± 3.2 days versus 4.6 ± 1.6 days in group 1, p < 0 .001). The frequency of prescription of other therapies did not differ between the compared groups. Use of mAbs significantly reduced mortality from 19.7% in KTRs in group 2 to 3% in group 1 without adverse effect on graft function. Conclusion. The use of mAbs therapy in the early stages of COVID-19 in KTRs is safe, it prevents severe COVID-19, and reduces the incidence of adverse outcomes.
Corpo-Cidade: Território da experiência
Authors: França Rebeca Falcão dos Santos Melo , Carvalho Gabriel Lincoln Lopes 
Published: April 2023

Corpo-cidade: Território da experiência, é uma pesquisa que tem como objetivo geral levantar reflexões acerca do corpo e da cidade, e de suas relações, propondo pensar a experiência do indivíduo com a cidade mediada através do nosso corpo, o corpo ao qual pertencemos. Tendo como objetivos específicos: Apresentar a cidade enquanto território de experiências e o corpo enquanto meio de experienciar o espaço. Utilizando como embasamento teórico fundamentado em pesquisas bibliográficas, procura-se aqui discutir esta relação a partir da ideia de corpo trazida por Merleau-Ponty ([1945] 2018), que explana este indivíduo capaz de reconhecer sua própria existência enquanto sujeito vivo e perceptivo, associando-o ao contexto da cidade trazidas durante os anais do Seminários de História da cidade e do urbanismo (SHCU), explicando a cidade enquanto espaço de vivências e interações, trabalhando-a para além de sua constituição material, pensando-a enquanto local de reduto da individualidade. É por meio desta discussão que buscamos elucidar a concepção de corpo e suas influências adivindas da cidade, mediante seu caráter perceptivo, apresentando a cidade enquanto fenômeno que se evidencia pela percepção e o corpo enquanto meio de vivenciar o espaço e compreender a expressão do viver urbano.

PALAVRAS-CHAVE: Corpo. Cidade. Experiência