bluuebunny/crossref_metadata_2025_split huggingface dataset:
“I Thought It Was Going to Be Trash”: Rural High School Students’ Disability-Related Perception Change Following Paralympic School Day
Authors: McKay Cathy , Kirk T.N. , Leake Marie 
Published: February 2023

Purpose: The purpose of this study was to describe and understand the experiences and impact of the Paralympic School Day program on disability-related perceptions of rural high school students. Methods: Ninth- and tenth-grade physical education classes from a rural high school participated in the Paralympic School Day event. Of the 68 who attended the event, 42 students furnished assent and consent to participate. Data from reflective writing responses were analyzed inductively using a three-step approach. Findings: The analysis revealed three interrelated themes: (a) “I didn’t expect it to be fun”: preconceptions and reality of trying parasport, (b) “Anyone can play a sport”: developing new perceptions of disability, and (c) “I never realized how blessed I was”: persistence of ableist framing. Discussion: As a result of participants interacting with and learning from athletes with physical disabilities, they developed an understanding of parasport and a new paradigm through which to view individuals with disabilities.
The effectiveness and sustainability of peer support interventions for persons living with HIV: a realist synthesis
Authors: Han Shuyu , Zhang Yizhu , Yang Xianxia , Chai Xinru , Guo Jinzheng , Zhang Lili , Shao Ying , Ma Jianhong , Li Ke , Wang Zhiwen 
Published: February 2023

BackgroundPeer support is an important supplement to medical resources for persons living with HIV (PLHIV). However, previous studies have shown mixed results about intervention effects. It is necessary to explain the mechanism of peer support interventions’ effectiveness and sustainability to help design more valid peer support interventions.ObjectiveTo identify and explain the mechanisms that drive the effectiveness and maintain the sustainability of peer support interventions.MethodsA preliminary theoretical framework was developed through a scoping review of the grey literature and international project frameworks in five professional websites. We then refined the framework by systematically searching evidence in databases including PubMed, EMBASE, Web of Science, ProQuest, CINAHL, CNKI and Wanfang. Qualitative methods were used to generate codes and themes relating to the studies’ context, mechanisms and outcomes. We checked chains of inference (connections) across extracted data and themes through an iterative process.ResultsA total of 6345 articles were identified, and 52 articles were retained for final synthesis. The refined theoretical framework presents five areas of peer support, including informational support, instrumental support, emotional support, affiliational support and appraisal support; five types of outcomes that peer support can improve for PLHIV, including physiological outcomes, psychological outcomes, behavioural outcomes, cognitive outcomes and social outcomes; the effectiveness mechanism coding system from peer volunteers and the relationship between peer volunteers and PLHIV; and the sustainability mechanism coding system in terms of peer volunteers, PLHIV and study context.ConclusionsGiven that peer support has huge potential human resources, that is, all the qualified PLHIV, irreplaceable advantages in dealing with barriers to HIV-related discrimination and potential comprehensive benefits for PLHIV, it is necessary to develop and organise more peer support projects for PLHIV. Our study highlights that the expansion of peer support projects should be based on their effectiveness and sustainability.PROSPERO registration numberCRD42022339079.
Digital Neuropathy by Hypertrophy and Hyperplasia of Pacinian Corpuscle – Usefulness of Microscopic Resection
Authors: KOBAYASHI Masato , MURAMATSU Keiichi , TANI Yasuhiro , MAGTOTO Ian Jason 
Published: February 2023

We present a patient with Pacinian corpuscle hypertrophy and hyperplasia in the hand and discuss the diagnosis and treatment of this rare condition. A 46-year-old woman presented with radiating pain of the left middle finger. A strong Tinel-like sign was elicited between the index and middle fingers. The patient frequently used mobile phone, with the corner of the phone consistently applying pressure on the palm. The surgery was carried out under the microscope and two enlarged cystic lesions under the epineurium were found in the proper digital nerve. Histologic examination revealed hypertrophied Pacinian corpuscle with normal structure. Postoperatively, her symptoms gradually improved. Preoperative diagnosis of this disease is very difficult. Hand surgeons should keep this disease in mind preoperatively. In our case, we would not have been able to identify multiple hypertrophic Pacinian corpuscles without the microscope. An operating microscope is recommended in a surgery of this nature. Level of Evidence: Level V (Therapeutic)
Tumor Mutational Burden as a Predictor of Survival with Durvalumab and/or Tremelimumab Treatment in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Authors: Wildsmith Sophie , Li Weimin , Wu Song , Stewart Ross , Morsli Nassim , Raja Rajiv , Zhang Qu , Ye Jiabu , He Philip , Shetty Jagdish , Yovine Alejandro , Holoweckyj Nicholas , Real Katia , Walker Jill , Wrona Magdalena , de los Reyes Melissa , Barker Craig , Whiteley Jessica , Haddad Robert , Licitra Lisa , Ferris Robert , Fayette Jérôme , Zandberg Dan P. , Siu Lillian L. , Mesía Ricard 
Published: February 2023

Abstract

Purpose:
Biomarkers that predict response to immune checkpoint inhibitors (ICI) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) are needed. This retrospective study assessed tumor mutational burden (TMB) and outcomes in the phase II HAWK and CONDOR and phase III EAGLE studies of durvalumab with or without tremelimumab in platinum-resistant R/M HNSCC.

Patients and Methods:
Tumor samples from HAWK/CONDOR (N = 153) and blood samples from EAGLE (N = 247) were analyzed for TMB. Associations with survival were evaluated for tissue TMB (tTMB) at cutoffs from 10 to 20 mutations/megabase (mut/Mb) and for blood plasma TMB (bTMB) at cutoffs from 8 to 24 mut/Mb.

Results:
In HAWK/CONDOR, overall survival (OS) with durvalumab with or without tremelimumab was longer for high versus low tTMB: statistically significant differences were observed with durvalumab plus tremelimumab at tTMB ≥ 10 mut/Mb [HR, 0.52 (95% confidence interval, CI, 0.28–0.98)] and tTMB ≥ 12 mut/Mb [HR, 0.46 (95% CI, 0.24–0.86)]. In EAGLE, a significant OS benefit versus chemotherapy was observed with durvalumab and durvalumab plus tremelimumab at bTMB≥16 mut/Mb [HR, 0.39 (95% CI, 0.20–0.76) and 0.38 (95% CI, 0.19–0.78), respectively] but not bTMB &lt; 16 mut/Mb [HR, 0.92 (0.61–1.37) and 0.92 (95% CI, 0.62–1.36), respectively]. A significant progression-free survival benefit was also observed in the ICI arms versus chemotherapy at bTMB ≥ 16 mut/Mb.

Conclusions:
Findings support TMB as a biomarker for predicting survival in patients with platinum-resistant R/M HNSCC treated with ICIs. The analysis of EAGLE demonstrated that bTMB was predictive of survival with ICI treatment versus chemotherapy in a large, randomized controlled study population.
Comparative Genomic Profiling of Second Breast Cancers following First Ipsilateral Hormone Receptor–Positive Breast Cancers
Authors: Rassy Elie , Garberis Ingrid , Tran-Dien Alicia , Job Bastien , Chung-Scott Véronique , Bouakka Ibrahim , Bassil Josiane , Ferkh Rachel , Lacroix-Triki Magali , Zanconati Fabrizio , Giudici Fabiola , Generali Daniele , Rouleau Etienne , Lacroix Ludovic , Andre Fabrice , Pistilli Barbara 
Published: February 2023

Abstract

Purpose:
We compared the mutational profile of second breast cancers (SBC) following first ipislateral hormone receptor–positive breast cancers of patient-matched tumors to distinguish new primaries from true recurrences.

Experimental Design:
Targeted next-generation sequencing using the Oncomine Tumor Mutation Load Assay. Variants were filtered according to their allele frequency ≥ 5%, read count ≥ 5X, and genomic effect and annotation. Whole genome comparative genomic hybridization array (CGH) was also performed to evaluate clonality.

Results:
Among the 131 eligible patients, 96 paired first breast cancer (FBC) and SBC were successfully sequenced and analyzed. Unshared variants specific to the FBC and SBC were identified in 71.9% and 61.5%, respectively. Paired samples exhibited similar frequency of gene variants, median number of variants per sample, and variant allele frequency of the reported variants except for GATA3. Among the 30 most frequent gene alterations, ARIDIA, NSD2, and SETD2 had statistically significant discordance rates in paired samples. Seventeen paired samples (17.7%) exhibited common variants and were considered true recurrences; these patients had a trend for less favorable survival outcomes. Among the 8 patients with available tissue for CGH analysis and considered new primaries by comparison of the mutation profiles, 4 patients had clonally related tumors.

Conclusions:
Patient-matched FBC and SBC analysis revealed that only a minority of patients exhibited common gene variants between the first and second tumor. Further analysis using larger cohorts, preferably using single-cell analyses to account for clonality, might better select patients with true recurrences and thereby better inform the decision-making process.
Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy
Authors: Garmany Ramin , Bos J. Martijn , Tester David J. , Giudicessi John R. , dos Remedios Cristobal G. , Dasari Surendra , Nagaraj Nagaswaroop K. , Nair Asha A. , Johnson Kenneth L. , Ryan Zachary C. , Maleszewski Joseph J. , Ommen Steve R. , Dearani Joseph A. , Ackerman Michael J. 
Published: February 2023

Background:
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy. Currently, hypertrophy pathways responsible for HCM have not been fully elucidated. Their identification could serve as a nidus for the generation of novel therapeutics aimed at halting disease development or progression. Herein, we performed a comprehensive multi-omic characterization of hypertrophy pathways in HCM.

Methods:
Flash-frozen cardiac tissues were collected from genotyped HCM patients (n=97) undergoing surgical myectomy and tissue from 23 controls. RNA sequencing and mass spectrometry–enabled deep proteome and phosphoproteomic assessment were performed. Rigorous differential expression, gene set enrichment, and pathway analyses were performed to characterize HCM-mediated alterations with emphasis on hypertrophy pathways.

Results:
We identified transcriptional dysregulation with 1246 (8%) differentially expressed genes and elucidated downregulation of 10 hypertrophy pathways. Deep proteomic analysis identified 411 proteins (9%) that differed between HCM and controls with strong dysregulation of metabolic pathways. Seven hypertrophy pathways were upregulated with antagonistic upregulation of 5 of 10 hypertrophy pathways shown to be downregulated in the transcriptome. Most upregulated hypertrophy pathways encompassed the rat sarcoma-mitogen-activated protein kinase signaling cascade. Phosphoproteomic analysis demonstrated hyperphosphorylation of the rat sarcoma-mitogen-activated protein kinase system suggesting activation of this signaling cascade. There was a common transcriptomic and proteomic profile regardless of genotype.

Conclusions:
At time of surgical myectomy, the ventricular proteome, independent of genotype, reveals widespread upregulation and activation of hypertrophy pathways, mainly involving the rat sarcoma-mitogen-activated protein kinase signaling cascade. In addition, there is a counterregulatory transcriptional downregulation of the same pathways. Rat sarcoma-mitogen-activated protein kinase activation may serve a crucial role in hypertrophy observed in HCM.
8-Aminoguanine and Its Actions on Renal Excretory Function
Authors: Jackson Edwin K. , Gillespie Delbert G. , Mi Zaichuan 
Published: February 2023

Background:
The endogenous purine 8-aminoguanine induces diuresis/natriuresis/glucosuria by inhibiting PNPase (purine nucleoside phosphorylase); however, mechanistic details are unknown.

Methods:

Here, we further explored in rats 8-aminoguanine’s effects on renal excretory function by combining studies using intravenous 8-aminoguanine, intrarenal artery infusions of PNPase substrates (inosine and guanosine), renal microdialysis, mass spectrometry, selective adenosine receptor ligands, adenosine receptor knockout rats, laser doppler blood flow analysis, cultured renal microvascular smooth muscle cells, HEK293 cells expressing A
2B
receptors and homogeneous time resolved fluorescence assay for adenylyl cyclase activity.

Results:

Intravenous 8-aminoguanine caused diuresis/natriuresis/glucosuria and increased renal microdialysate levels of inosine and guanosine. Intrarenal inosine, but not guanosine, exerted diuretic/natriuretic/glucosuric effects. In 8-aminoguanine-pretreated rats, intrarenal inosine did not induce additional diuresis/natriuresis/glucosuria. 8-Aminoguanine did not induce diuresis/natriuresis/glucosuria in A
2B
-receptor knockout rats, yet did so in A
1
- and A
2A
-receptor knockout rats. Inosine’s effects on renal excretory function were abolished in A
2B
knockout rats. Intrarenal BAY 60-6583 (A
2B
agonist) induced diuresis/natriuresis/glucosuria and increased medullary blood flow. 8-Aminoguanine increased medullary blood flow, a response blocked by pharmacological inhibition of A
2B
, but not A
2A
, receptors. In HEK293 cells expressing A
2B
receptors, inosine activated adenylyl cyclase, and this was abolished by MRS 1754 (A
2B
antagonist). In renal microvascular smooth muscle cells, 8-aminoguanine and forodesine (PNPase inhibitor) increased inosine and 3’,5’-cAMP; however, in cells from A
2B
knockout rats, 8-aminoguanine and forodesine did not augment 3’,5’-cAMP yet increased inosine.

Conclusions:

8-Aminoguanine induces diuresis/natriuresis/glucosuria by increasing renal interstitial levels of inosine which, via A
2B
receptor activation, increases renal excretory function, perhaps in part by increasing medullary blood flow.
Imagination and Belief
Authors: Taylor George H. 
Published: February 2023

Abstract
In his forthcoming Lectures on Imagination, Paul Ricoeur develops his theory by contending that the imagination may be understood across two axes. The first, horizontal axis moves from reproductive imagination at the left end to productive imagination on the right. A second, vertical axis moves from belief at the bottom to critical distance at the top. This article examines his vertical axis and seek to comprehend and appraise his distinction between imagination as belief and as critical distance. Elaboration of the vertical axis remains significant both as a matter of exegesis internal to the Lectures and, more substantively, as an opening, perhaps especially in our parlous times, to the availability of a distinction between critical distance and being captured by belief. While the article values the potential positive role of critical distance as providing a location for alternative perspectives on and critique of existing imaginative frameworks, it questions Ricoeur’s claims that the vertical axis permits even at the top an escape from belief or that belief is necessarily negative. In developing this response, the article initially returns to subtleties in Ricoeur’s presentation in the Lectures that his main argument on the vertical axis does not pursue, and it then turns to engage in a contrast between Ricoeur’s argument in the Lectures and his argument in the Lectures on Ideology and Utopia. Part of the claim is that perspectives in both hermeneutics and phenomenology to which Ricoeur otherwise adheres challenge his conclusion that critical distance permits an escape from belief. These perspectives also challenge the kind of phenomenological stance Ricoeur develops and so reveal conflicts between hermeneutics and phenomenology and between various strands of phenomenology. The article develops its analysis in particular by distinguishing between Ricoeur’s emphasis on imagination as as if or as seeing as. The article concludes by showing the interrelation of the argument about the persistence of belief to contemporary theory in behavioral economics. The article’s thesis, then, has substantial implications for the construction of Ricoeur’s vertical axis, for the implications of this axis in relation to Ricoeur’s other work, and for its engagement with and expansion of contemporary social theory.
Wild Being, between Ontology and Politics: Merleau-Ponty, Lefort, Castoriadis
Authors: Poirier Nicolas 
Published: February 2023

Abstract
This essay considers the philosophical implications and the political ramifications of the dispute between Lefort and Castoriadis. It argues that the meaning of the conflict is best captured through consideration of Merleau-Ponty’s notion of wild being as it appears in his later thought. It considers Merleau-Ponty’s varying influence on Castoriadis and Lefort’s respective trajectories and explores how their different approaches to ontology plays out to the response to the problematic of the political. Whilst both Castoriadis and Lefort pursue a non-foundationalist ontology, they differ on the issue of the origin of nomos, and their different interpretations of—and break with—Marx leads to significantly different conclusions about the prospect of society and autonomy.
An application of mixed-effects model to evaluate the role of age and size on radial variation in wood specific gravity in teak (Tectona grandis)
Authors: Adutwum Jerry Oppong , Sakagami Hiroki , Koga Shinya , Matsumura Junji 
Published: February 2023

AbstractTo test whether radial variation of wood specific gravity (WSG) is controlled by tree age or tree size in teak (Tectona grandis L.f) plantation trees, opposing different-length pith-to-bark strips which represents the differential lateral growth rate was compared using mixed-effects model which considers the heterogeneity of variances and dependency in the data to gain insight into the stochastic processes that govern the wood formation process. Various models were tested in devising an appropriate radial WSG model. Models that accounted for serial correlation in WSG data performed better than the simple structure that assumes zero correlation between measurements. The autoregressive plus random tree effect structure performed better in describing the radial variation pattern. The variability of the data related to random fluctuations during tree development and the wood formation process is modeled by the autoregressive parameter revealing the intrinsic complexity of wood formation. Since they cannot be attributed to observed factors, models should consider temporal or serial correlations when assessing wood quality. The results revealed that tree age is a decisive factor in controlling the WSG of wood, while tree size is statistically less important. Furthermore, the core wood production period varies with the growth rate. It is shown that the core wood area decreased with slow growth. Findings presented here appear to provide the first demonstration of radial variation in WSG with respect to growth rate and age for planted teak growing in Ghana.
A generalized covariate-adjusted top-scoring pair algorithm with applications to diabetic kidney disease stage classification in the Chronic Renal Insufficiency Cohort (CRIC) Study
Authors: Kwan Brian , Fuhrer Tobias , Montemayor Daniel , Fink Jeffery C. , He Jiang , Hsu Chi-yuan , Messer Karen , Nelson Robert G. , Pu Minya , Ricardo Ana C. , Rincon-Choles Hernan , Shah Vallabh O. , Ye Hongping , Zhang Jing , Sharma Kumar , Natarajan Loki 
Published: February 2023

Abstract
Background
The growing amount of high dimensional biomolecular data has spawned new statistical and computational models for risk prediction and disease classification. Yet, many of these methods do not yield biologically interpretable models, despite offering high classification accuracy. An exception, the top-scoring pair (TSP) algorithm derives parameter-free, biologically interpretable single pair decision rules that are accurate and robust in disease classification. However, standard TSP methods do not accommodate covariates that could heavily influence feature selection for the top-scoring pair. Herein, we propose a covariate-adjusted TSP method, which uses residuals from a regression of features on the covariates for identifying top scoring pairs. We conduct simulations and a data application to investigate our method, and compare it to existing classifiers, LASSO and random forests.

Results
Our simulations found that features that were highly correlated with clinical variables had high likelihood of being selected as top scoring pairs in the standard TSP setting. However, through residualization, our covariate-adjusted TSP was able to identify new top scoring pairs, that were largely uncorrelated with clinical variables. In the data application, using patients with diabetes (n = 977) selected for metabolomic profiling in the Chronic Renal Insufficiency Cohort (CRIC) study, the standard TSP algorithm identified (valine-betaine, dimethyl-arg) as the top-scoring metabolite pair for classifying diabetic kidney disease (DKD) severity, whereas the covariate-adjusted TSP method identified the pair (pipazethate, octaethylene glycol) as top-scoring. Valine-betaine and dimethyl-arg had, respectively, ≥ 0.4 absolute correlation with urine albumin and serum creatinine, known prognosticators of DKD. Thus without covariate-adjustment the top-scoring pair largely reflected known markers of disease severity, whereas covariate-adjusted TSP uncovered features liberated from confounding, and identified independent prognostic markers of DKD severity. Furthermore, TSP-based methods achieved competitive classification accuracy in DKD to LASSO and random forests, while providing more parsimonious models.

Conclusions
We extended TSP-based methods to account for covariates, via a simple, easy to implement residualizing process. Our covariate-adjusted TSP method identified metabolite features, uncorrelated from clinical covariates, that discriminate DKD severity stage based on the relative ordering between two features, and thus provide insights into future studies on the order reversals in early vs advanced disease states.