bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Management of Head and Neck patient treatment using Statistical Process Control techniques
Authors: Sandford Michael , Steel Jared G , Goodworth Josie , Lodge Patrick 
Published: August 2023

Abstract

The treatment, planning, simulation, and setup of radiotherapy patients contain many processes subject to errors involving both staff and equipment. Cone-beam-CT (CBCT) provides a final check of patient positioning and corrections based on this can be made prior to treatment delivery. Statistical Process Control (SPC) techniques are used in various industries for quality management and error mitigation. The utility of SPC techniques to monitor process and equipment changes in our Head and Neck patient treatments was assessed by application to CBCT results from a quality-focused longitudinal study. Both individuals and moving range (XmR) as well as exponentially-weighted moving average (EWMA) techniques were explored. The SPC techniques were sensitive to process changes and trends over the 10 years of data collected. A reduction in the random component of patient setup errors needing correction was observed. Systematic components of error remained stable, with a small uptick correlating with COVID measures observed. Process control limits for use in prospective process monitoring were established. Challenges that arose from using SPC techniques in a retrospective study are outlined.
Minimum dietary diversity and associated factors among children aged 6-23 months in Ghana: a cross-sectional study
Authors: Ativor Pearl Saraphina , Salu Samuel 
Published: August 2023

Abstract
Background: The golden period in the first 1000 days of life is between the ages of 6 and 23 months. This period is referred to as a critical window because it promotes the optimal growth and development of the child. However, the nutritional status of children in this critical period is strongly influenced by their feeding patterns, which in turn has an impact on their survival. Inappropriate supplementary feeding techniques put children under the age of two at danger of malnutrition, illness, and death. This study therefore, assesses the minimum dietary diversity and its associated factors among children between the age 6-23 months in the Hohoe Municipality, in the Volta Region of Ghana.
Methods: A health facility-based cross-sectional study was conducted from April to July 2021. A multi-stage sampling technique was used to sample 422 study participants. Data were collected with a paper-based questionnaire, coded and entered into Epi-Data version 3.1. Data extraction was carried out in Excel Sheet for cleaning and then later exported into STATA V.16.0 for analysis. Logistic regression was fitted to identify significant factors associated with high MDD at 95% CI and a p-value < 0.05.
Results:Out of the 422 participants, majority of them 343 (81.0%) had good dietary practices. The prevalence of MDD among the children was 17.1%. On the other hand, the educational level of mothers [cOR=3.12 (95% CI: 1.57-6.19), p=0.001], their ethnicity [cOR=4.69 (95% CI: 1.55-14.19), p=0.006], their occupation [cOR=2.18 (95% CI: 1.15-4.11), p=0.017] and their dietary practices [cOR= 0.72 (95% CI: 0.13-3.92), p=0.008] were found to be significantly associated with children’s MDD. After controlling for other co-variates, only educational level [aOR=3.16 (95% CI: 0.75-13.29), p=0.001] and ethnicity [aOR=24.72 (1.43-15.64), p=0.011] were statistically associated with children’s high MDD.
Conclusion: The study concludes that while MDD was low among the children, breastfeeding was common but gaps existed in providing essential food groups, with significant influences from maternal education and ethnicity, highlighting the need for targeted interventions to enhance dietary practices for children aged 6-23 months.
Anti-inflammation study of cellulose-chitosan biocomposite-based Tetrapleura tetraptera (Taub) dried fruits aqueous extract
Authors: Fokou Jean Baptiste Hzounda , Nsegbe Annick Christianne , Yen Beglau Thi Hai , Fetzer Marcus N. A. , Mbogbe Elise Nadia , Nkouankam Maeva Jenna Chameni , Mponge Pamela Ngadie , Baleng Marie Tryphene Magaly Ngo Yomkil , Songue Sylvie Pascale , Kuissi Chris Rosaire Ninpa , Koube Juliette , Enone Bertin Sone , Ntoumba Agnes Antoinette , Meva Francois Eya’ane , Janiak Christoph 
Published: August 2023

Abstract

Nanotechnology is making exceptional progress in the medical field. The development of new systems for the delivery of plant ingredients brings benefits such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocomposites from Tetrapleura tetraptera despite its wide range of ethnopharmacological uses including management of the inflammatory diseases. This study aimed to prepare chitosan and cellulose-based nanocomposite with anti-inflammatory potential. The biocomposite showed an encapsulation efficiency of 69.4%. Their formation was confirmed by a peak at 290 nm in UV-Vis. Infrared spectrophotometry proves the formation of a mixed polysaccharide and polyphenols system. No signs of toxicity and no deaths were found, therefore the lethal dose 50 (LD50) is higher than 2000 mg/kg. The biocomposite has an anti-inflammatory activity in vitro with a maximum inhibition of 99.5% and an anti-inflammatory activity in vivo with a maximum inhibition of 98.7% for a dose of 200 mg/kg. The synthesized biocomposite from the aqueous extract of the fruits of Tetrapleura tetraptera showed an anti-inflammatory property with satisfactory safety.
Order-preserving Property of One-parameter Expo nential Distribution MLE under Type-I Censoring
Authors: Liu Xiaofeng , Ren Jianguo , Bingliang Shen , Ping Luo 
Published: August 2023

Abstract
Many researchers have studied various properties of maximum likelihood estimators as well as estimators for truncated samples.However,the order preserving properties of maximum likelihood estimation for censored samples have not been studied in the literature. This is precisely the subject of this paper. In this paper, we derive general necessary conditions under which the MLE has the general necessary conditions. In particular, the paper obtains conditions under which the one-parameter exponential, location, and scale families satisfy the order preserving property.
Human-AI Collaborative Decision-making: A Cognitive Ergonomics Approach
Authors: Neyigapula Bheema Shanker 
Published: August 2023

Abstract

This research paper explores the dynamic interplay between human cognition and artificial intelligence (AI) in the context of decision-making, employing a cognitive ergonomics framework. As AI technologies continue to evolve and inte- grate into various aspects of human life, the collaboration between humans and AI becomes increasingly significant. This study investigates the cognitive load experienced by individuals during collaborative decision-making processes with AI systems, aiming to optimize interface design for enhanced cognitive perfor- mance. Leveraging principles of cognitive ergonomics, the research examines how varying degrees of AI involvement impact decision-making efficiency, user trust, and transparency. By employing a mixed-methods approach involving cognitive workload assessments and user experience analyses, the study sheds light on the intricacies of human-AI collaboration. The findings not only contribute to the theoretical understanding of cognitive ergonomics in the context of AI but also offer practical insights for the design and implementation of effective human-AI decision support systems.
When two Z-scores meet - Analysis of exercise capacity of children and adolescents with Kawasaki disease by a new Z-score model of coronary artery and a new Z-score evaluating peak oxygen consumption
Authors: Tuan Sheng-Hui , Chung Jin-Hui , Chen Guan-Bo , Sun Shu-Fen , Liou I-Hsiu , Li Chien-Hui , Tsai Yi-Ju 
Published: August 2023

Abstract
Background
Coronary artery (CA) Z-score system is widely used to define CA aneurysm (CAA). Children and adolescents after acute stage of Kawasaki disease (KD-CA) have a higher risk of developing CAAs if their CA Z-score ≥ 2.5. Z-score system of peak oxygen consumption (Peak VO2 Z-score) allows comparisons across ages and sex, regardless of body size and puberty. We aimed to compare the exercise capacity (EC) indicated by peak VO2 Z-score during cardiopulmonary exercise testing (CPET) directly between KD-CA with different CA Z-score.
Methods
KD-CA after acute stage who received CPET in the last 5 years were retrospectively recruited. CA Z-score was based on Lambda-Mu-Sigma method. Max-Z was the maximum CA Z-score of different CAs. KD children with Max-Z < 2.5 and ≥ 2.5 were defined as KD-1 and KD-2 groups, respectively. Peak VO2 Z-score was calculated using the equation established based on Hong Kong Chinese children and adolescent database.
Results
102 KD-CA were recruited (mean age: 11.71 ± 2.57 years). The mean percent of measured peak VO2 to predicted value (peak PD%) was 90.11 ± 13.33. All basic characteristics and baseline pulmonary function indices were comparable between KD-1 (n = 87) and KD-2 (n = 15). KD-1 had significantly higher peak VO2 Z-score (p = .025), peak PD% (p = .008), peak metabolic equivalent (p = .027), and peak rate pressure product (p = .036) than KD-2.
Conclusions
KD-CA had slightly reduced EC than healthy peers. KD-CA with Max-Z ≥ 2.5 had significantly lower peak EC than those < 2.5. Max-Z is potentially useful follow-up indicator after acute stage of KD.
Magnetic Nanoparticle Supported Choline Chloride-Glucose (Deep Eutectic Solvent) for the One-Pot Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-ones
Authors: Atharifar Hengameh , Keivanloo Ali , Maleki Behrooz , Baghayeri Mehdi , Alinezhad Heshmatollah 
Published: August 2023

Abstract
One efficient method for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives catalyzed magnetic deep eutectic solvent is reported. The structure of the nano-catalyst was characterized by FE-SEM, FT-IR, EDX, and TGA. Then, the excellent activity of the catalyst was displayed for the synthesis of 3,4-disubstituted isoxazole-5(4H)-ones derivatives. This heterogeneous catalyst can be easily recovered via a magnetic field and reused for subsequent reactions. Easy workup, high yields in a short time and non-toxic catalyst are the main merits of this method.
Regional monthly rainfall prediction based on CEEMDAN-SSA-BiLSTM coupled modeling
Authors: Zhang Xianqi , Ren He , Liu Jiawen 
Published: August 2023

Abstract
Accurate rainfall prediction plays a vital role in optimizing water resource management, reducing impacts on water resources and related water conservation and utilization.. This study combines the advantages of CEEMDAN model's ability to handle nonlinear and nonstationary data, SSA model to decompose and reconstruct the data to get the subsequence with spatio-temporal information, BiLSTM model to effectively learn the dependency relationship between the current data and the data of the previous moment, and to use the relationship to predict the rainfall in the future moments to construct the regional monthly rainfall prediction model of CEEMDAN-SSA-BiLSTM and applied it to predict monthly rainfall in Kaifeng City. The findings indicate that the proposed model is effective for accurately predicting monthly rainfall in the city of Kaifeng. Compared with the EMD-SSA-BiLSTM, CEEMDAN-BiLSTM, and BiLSTM models, the CEEMDAN-SSA-BiLSTM model achieves higher accuracy with an average absolute error (MAE) of 3.75, an average absolute percentage error (MAPE) of 5.44%, and a coefficient of determination (R2) of 0.99. Furthermore, the decomposition of monthly rainfall time series signals helps in identifying and revealing cycles and trends in the series, thereby effectively improving the prediction accuracy of monthly rainfall.
α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis.
Authors: Pérez-Acuña Dayana , Shin Soo Jean , Rhee Ka Hyun , Kim Sang Jeong , Lee Seung-Jae 
Published: August 2023

Abstract
The major neuropathologic feature of Parkinson’s disease is the presence of widespread intracellular inclusions of α-synuclein known as Lewy bodies. Evidence suggests that these misfolded protein inclusions spread through the brain with disease progression. Changes in synaptic function precede neurodegeneration, and this extracellular α-synuclein can affect synaptic transmission. However, whether and how the spreading of α-synuclein aggregates modulates synaptic function before neuronal loss remains unknown. In the present study, we investigated the effect of intrastriatal injection of α-synuclein preformed fibrils (PFFs) on synaptic activity in the somatosensory cortex using a combination of whole-cell patch-clamp electrophysiology, histology, and Golgi-Cox staining. Intrastriatal PFF injection was followed by formation of phosphorylated α-synuclein inclusions in layer 5 of the somatosensory cortex, leading to a decrease in synapse density, dendritic spines, and spontaneous excitatory post-synaptic currents, without apparent neuronal loss. Additionally, three-dimensional reconstruction of microglia using confocal imaging showed an increase in the engulfment of synapses. Collectively, our data indicate that propagation of α-synuclein through neural networks causes abnormalities in synaptic structure and dynamics prior to neuronal loss.
Immunotheranostic target modules for imaging and navigation of UniCAR T-cells to strike FAP-expressing cells and the tumor microenvironment
Authors: Loureiro Liliana Rodrigues , Hoffmann Lydia , Neuber Christin , Rupp Luise , Arndt Claudia , Kegler Alexandra , Kubeil Manja , Hagemeyer Christoph E. , Stephan Holger , Schmitz Marc , Feldmann Anja , Bachmann Michael 
Published: August 2023

Abstract
Background
Chimeric antigen receptor (CAR) T-cells are a promising approach in cancer immunotherapy, particularly for treating hematologic malignancies. Yet, their effectiveness is limited when tackling solid tumors, where immune cell infiltration and immunosuppressive tumor microenvironments (TME) are major hurdles. Fibroblast activation protein (FAP) is highly expressed on cancer-associated fibroblasts (CAFs) and various tumor cells, playing an important role in tumor growth and immunosuppression. Aiming to modulate the TME with increased clinical safety and effectiveness, we developed novel small and size-extended immunotheranostic UniCAR target modules (TMs) targeting FAP.
Methods
The specific binding and functionality of the αFAP-scFv TM and the size extended αFAP-IgG4 TM were assessed using 2D and 3D in vitro models as well as in vivo. Their specific tumor accumulation and diagnostic potential was evaluated using PET studies after functionalization with a chelator and suitable radionuclide.
Results
The αFAP-scFv and -IgG4 TMs effectively and specifically redirected UniCAR T-cells using 2D, 3D, and in vivo models. Moreover, a remarkably high and specific accumulation of radiolabeled FAP-targeting TMs at the tumor site of xenograft mouse models was observed.
Conclusions
These findings demonstrate that the novel αFAP TMs are promising immunotheranostic tools to foster cancer imaging and treatment, paving the way for a more convenient, individualized, and safer treatment of cancer patients.
Health risk assessment from habitants of Araró, Michoacán, México, exposed to arsenic by dust, using Monte Carlo probabilistic method.
Authors: Mendoza José , Aguilar Alejandra , Rodríguez Laura , Guerra Roberto , Meza Diana , Meza Mercedes , Martínez Marco Antonio 
Published: August 2023

Abstract

Arsenic (As) is a worldwide distributed metalloid; and its environmental exposure by various media has been associated with some diseases such as: lung, skin, bladder and pancreas cancers, diabetes, cardiovascular disorders and atherosclerosis. Environmental presence of As may be due to natural origin, human activities or geothermal processes. Michoacán is located in the volcanic transverse system which is a highly active geothermal site in center México. The aim of this research was to assess the health risk for As exposure by dust of Araró´s population using Monte Carlo simulation. 40 dust samples were randomly collected in Araró village, located in northeast Michoacán, and these were analyzed using portable X-ray fluoroscopy. The arsenic levels obtained for the dust samples were in the range of 5.94–42.53 mg/kg. Health risk was assessed using USEPA formulas and Monte Carlo Simulation for oral, dermal and inhalation pathways. Anthropometrical data were obtained from the Health and Nutrition National Survey 2018.Mean average daily dose (ADD) for all age groups (preschooler, schooler, adolescent and adult) were below of safety criteria. 4 and 6% of preschooler and schooler dermal ADD’s were above of safety criteria. In the same way, hazard quotient (HQ) and hazard index (HI) mean values were below of safety criteria. Nevertheless, it was found that dermal carcinogenic risk (CR) value for adults tends to represents a potential cancer risk. Despite of relatively low As concentration reported it is remarkable that more As exposition routs must be explore in order to determine problem severity.
Commuters' mode and parking decisions
Authors: Wagner Jake , Moore Danna , Jessup Eric , Vakoch Daniel 
Published: August 2023

Abstract

We analyze how both fee and non-fee commute attributes affect commuters’ mode and parking decisions. Results show commuters are sensitive to the price, travel time, egress time, and search time in selecting their primary commute mode, but are not sensitive to other travel costs including the costs of fuel and maintenance. Using these results we conduct policy simulations to analyze how changes in transit prices, travel times, and parking availability affect commuters' mode and parking decisions. We find raising parking permit prices and decreasing bus travel times to be effective in reducing the number of single occupancy vehicle commuters; the closure of central parking locations, however, is found to be ineffective in discouraging commuters from driving to campus as drivers are more likely to switch parking locations than they are commute modes.
miR-483-3p targets FGFR2 to inhibit cardiomyocyte pyroptosis NLRP3/Caspase-1/GSDMD signaling axis and reduce myocardial fibrosis
Authors: Lv Xiangwei , Chen Liqin , He Zifeng , Zhang Mingyu , Chen Rongyan , Xu Tongtong 
Published: August 2023

Abstract
Purpose
In this study, the role of miR-483-3p in reducing myocardial fibrosis (MF) is investigated and the underlying molecular mechanism is further explored.
Methods
Firstly, six SD rats were randomly divided into sham surgery (Sham) group and model (ISO) group, and high-throughput miRNAs sequencing technology was used to sequence MF model rats. Forty male SD rats were randomly divided into Sham group, ISO group, blank transfection (AAV-NC) group, and overexpression (AAV-miR-483-3p) group, with 10 rats in each group. The MF model was established by tail vein injection of isoprenaline. RT-PCR, Western Blot and immunohistochemical staining were used to detect the expression of miR-483-3p, FGFR2 and cell pyroptosis. Bioinformatics software TargetScan was used to predict targets online and verify with diluciferase reporters; Detection of myocardial fibrosis using HE staining, Masson staining and Western Blot.
Results
Compared with the ISO group, the degree of MF decreased in the AAV-miR-483-3p group, and the expression of Collagen-1, FGFR2, NLRP3, Caspase-1, GSDMD and IL-1β in cardiomyocytes was significantly reduced. Diluciferase experiments confirmed that FGFR2 is the validated target gene of miR-483-3p.
Conclusion
miR-483-3p targets FGFR2 to inhibit cell pyroptosis and reduce the degree of MF, possibly via the NLRP3/Caspase-1/GSDMD signaling axis.
Truncation of the Calmodulin Binding Domain in Rice Glutamate Decarboxylase 4 (OsGAD4) Leads to Accumulation of γ-Aminobutyric Acid and Confers Abiotic Stress Tolerance in Rice Seedlings
Authors: Akter Nadia , Kulsum Ummey , Yasuda Nobuto , Akama Kazuhito 
Published: August 2023

Abstract
Background Gamma-aminobutyric acid (GABA) is a non-protein amino acid known as a major inhibitory neurotransmitter. It is mainly synthesized from glutamate via the enzyme glutamate decarboxylase (GAD). GAD is present in all organisms, but only plant GAD has been shown to bind Ca2+/calmodulin (CaM). This binding suppresses the auto-inhibition of Ca2+/CaM binding domain (CaMBD) when the active site of GAD is unfolded, resulting in stimulated GAD activity. OsGAD4 is one of the five GAD genes in the rice genome. Conserved motifs in the C-terminal amino acid sequence suggest the potential ability of this GAD isoform to bind to Ca2+/CaM. Our aim was to produce GABA-fortified rice plants by genome editing of the OsGAD4 gene and comprehensive study of the truncated mutants.Results An in vitro Ca2+/CaM assay showed that the C-terminal region of putative GAD4 has the ability to bind to Ca2+/CaM. CRISPR/Cas9-mediated genome editing was performed to trim the coding region of CaMBD from the OsGAD4 gene. Rice calli infected with Agrobacterium carrying an all-in-one vector harboring guide RNAs and CRISPR/Cas9 was used to regenerate rice plants. We produced 27 independent transgenic lines (T0) through genome editing. DNA sequence analysis revealed the truncation of CaMBD (216 bp). Genome-edited line (#14 − 1) produced 12.9 mg GABA/100 g grain, which is almost 9-fold higher than the wild-type. Abiotic stresses such as salinity, flooding, and drought significantly enhanced GABA accumulation in #14 − 1 plants at various time points compared with wild-type controls in the same stress conditions. Moreover, upregulated mRNA expression in vegetative tissues seem to be correlated with the stress responsiveness of OsGAD4 when exposed to the above-mentioned stresses. The stress tolerance of OsGAD4 genome-edited plants was demonstrated by the higher survival rate, suggesting induced tolerance against abiotic stresses in rice.Conclusions Trimming of the intact Ca2+/CaMBD of the C-terminal region of OsGAD4 induced extreme GABA accumulation in plant tissues. This elevated level of GABA was found to be linked to abiotic stress tolerance in rice plants at the vegetative stage.