bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular mapping and transfer of sheath blight resistance QTLs from wild rice Oryza nivara to cultivated rice (Oryza sativa L.)
Authors: Neelam Kumari , Aggarwal Sumit , Kumari Saundriya , Kumar Kishor , Kaur Amandeep , Babbar Ankita , Lore Jagjeet Singh , Kaur Rupinder , Vikal Yogesh , Singh Kuldeep 
Published: January 2023

Abstract
Background
Sheath blight (ShB) is the most serious disease of rice (Oryza sativa L.), caused by a soil-borne fungus Rhizoctonia solani Kühn (R. solani). It limits global rice productivity by causing ~50% yield loss every year. Broad host range, rapid resurgence of new pathogen races, and the lack of highly resistant germplasm are the major caveat to managing this disease. Therefore, continuous scouting of new germplasm resources resistance to R. solani is urgently required.
Results
In this report, we identified a very promising resistance source O. nivara accession IRGC81941A which displays partial resistance across the five years of screening against R. solani. Quantitative trait loci (QTL) mapping was performed in F2 populations that identified a total of 29 QTLs with the total phenotypic variance explained (PVE) ranged from 4.70 to 48.05%. A cluster of four QTL qRLH1.1, qRLH1.2, qRLH1.5, and qRLH1.8 stably detected which showed consistent resistant response against R. solani. The size of these QTL ranging from 0.096-420.1 Kb, based on the rice reference genome harboring several important disease resistant genes such as Ser/Thr protein kinase, auxin-responsive protein, Protease inhibitor/seed storage/LTP family protein, MLO domain-containing protein, disease responsive protein, Thaumatin-like protein, Avr9/Cf9 eliciting protein, and many transcription factors. A simple sequence repeat (SSR) marker RM212 co-segregates with this QTL cluster.
Conclusion
Our finding suggests that a highly stable QTL cluster confers resistance to sheath blight disease. Effective transferring of this cluster as a single unit through backcross breeding marked the identification of three agronomically superior resistant lines. These promising germplasms could be an important pre-breeding material for varietal development. PCR-based SSR marker linked to these QTLs could facilitate efficient transfer of the QTLs into rice cultivars through marker-assisted selection programs.
Clinical characteristics and prognosis of elderly patients with anal cancer
Authors: Wang Xiaogan , Xiang Nengjun , Xu Xuemei , Chen Hongjin 
Published: January 2023

Abstract
Purpose. The clinical characteristicsand prognosis of anal cancer in the elderly have not received sufficient attention. The study aimed to evaluate the clinical features and prognostic factors of elderly patients with anal cancer.
Method. The characteristics of anal cancer patients (aged <65 and ≥65) diagnosed during 2004-2017 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to correct age bias caused by assessed confounders. The chi-squared (χ2) test was used to assess differences in categorical variables of characteristics between two age groups., The Kaplan-Meier survival technique, Log-rank test, Cox regression, and nomogram were used for survival analysis.
Results. The receipt of adjuvant age increases the risk of overall survival by 86% after propensity-score matching (HR=1.86, 95%CI=1.70-2.03,P<0.001). Compared with the younger population, the elderly accounted for a higher proportion of unmarried statuses and adenocarcinomas. COX regression analysis shows older age, non-squamous cell carcinoma, unmarried status, and advanced AJCC stage as independent risk prognostic factors for anal cancer in the elderly. The effects of chemotherapy, radiotherapy, and surgery all improved the prognosis of the elderly. Besides, senior score and survival probability could be accomplished by our nomogram with a c-index of 0.7179.
Conclusion. Relatively low rates of chemoradiation and relatively conservative therapy regimens are associated with a poorer prognosis in elderly anal cancer. At the same time, surgery has a potential role in improving the prognosis of elderly anal cancer patients.
First-Principles Calculations of SnCo as Potential Anode Materials for High-Performance Lithium-Ion Batteries and Beyond
Authors: Huang Zhuonan , Zhang Meiguang 
Published: January 2023

Abstract
Herein, first-principles calculations were carried out to investigate the mechanism of metal-ion, such as K, Li, Na, Mg and Al, adsorption and diffusion on the SnCo (0 0 1) surface. Our results demonstrated that K, Li, and Na are more readily adsorbed on the pristine SnCo (0 0 1) surface than Mg and Al. Based on the calculations of migration barriers for metal atom on SnCo (0 0 1) surface, we identified the most energetically favorable metal atom diffusion pathway. The influence of vacancies on the K and Li storage capabilition of the SnCo (0 0 1) surface was also investigated. Our calculations show that Sn vacancies (VSn) tend to improve Li adsorption, but have no effect on K adsorption. Unfortunately, the Co vacancy (VCo) tends to inhibit the adsorption of Li and K on the SnCo (0 0 1) surface.
WITHDRAWN: A voltage-driven dissoluble electrolyte additive enables high-rate and ultralong-life lithium metal batteries
Authors: Qiu Yongcai , Xu Qingshuai , Li Tan , Ju Zhijin , Lai Xuejun , Yan Keyou , Chen Guangxu , Ye Daiqi , Waterhouse Geoffrey , Lu Yingying , Zhou Guangmin , Tao Xinyong , Li Hong , Guo Lin 
Published: January 2023

Abstract
Developing a solid electrolyte interphase (SEI) with good stability and high Li-ion conductivity is critical for realizing high-rate and long-life lithium metal batteries (LMBs), yet still challenging. Herein, we demonstrate that adding excess m-Li2ZrF6 (monoclinic structure) nanoparticles to an ordinary commercial LiPF6-containing carbonate electrolyte used in LMBs facilitates the slow release of ZrF62- ions into the electrolyte via internal electrical field, thus creating a very stable SEI based on t-Li2ZrF6 (trigonal structure) with high Li-ion conductivity. Computational and cryogenic transmission electron microscopy experimental studies revealed that the in-situ formation of t-Li2ZrF6 nanocrystals in the hybrid SEI significantly enhanced Li-ion transfer and suppressed the growth of Li dendrites. As result, the LMBs assembled with LiFePO4 cathodes (2 mAh cm−2 areal capacity), 3D Li-carbon anodes (~50 µm thick Li) and the unique electrolyte displayed greatly improved cycling stability with 80.1% capacity retention after 3000 cycles at a 1 C rate. This work identifies a new and simple strategy to impart LMBs with ultralong lifespans under practical high-rate conditions.
How to treat endothelial failure after PK or DMEK: is DMEK the way to go?
Authors: Heinzelmann Sonja , Lapp Thabo , Böhringer Daniel , Maier Philip , Reinhard Thomas 
Published: January 2023

Abstract
Background
Descemet membrane endothelial keratoplasty (DMEK) may be an elegant solution for endothelial failure after penetrating keratoplasty (PK). However, it is currently unclear whether this approach comes with any long-term drawbacks concerning chronic endothelial cell loss, rebubbling rates, graft survival and severity of immune reactions. We therefore herein compare the outcomes of DMEK to repair failed PK to the outcomes of DMEK to repair failed DMEK grafts.
Methods
This retrospective study included 117 patients with DMEK after keratoplasty (82 following DMEK and 35 following PK). Postoperative visual acuity, endothelial cell count, rebubbling rates, graft survival and rejection rates were recorded. Kaplan-Meier-analysis was used to assess survival rates.
Results
Visual acuity improved, but stayed at a lower level in PK patients. Endothelial cell loss was more severe in patients with DMEK as an initial procedure, whereas rebubbling rates, graft failure and immune reactions did not differ significantly between both groups. Ratios of graft diameters of the first and second graft did not influence survival or rejection of the graft.
Conclusions
Repeat DMEK is an appropriate method of treating endothelial graft failure after both DMEK and PK. The higher endothelial cell loss in the DMEK-DMEK group may be due to a different recipient endothelial reservoir and assimilate in the long term follow-up. These data may encourage treating endothelial graft failure with DMEK even in PK eyes.
RNA Contact Prediction by Data Efficient Deep Learning
Authors: Taubert Oskar , Lehr Fabrice von der , Bazarova Alina , Faber Christian , Weiel Marie , Knechtges Philipp , Debus Charlotte , Coquelin Daniel , Basermann Achim , Streit Achim , Kesselheim Stefan , Götz Markus , Schug Alexander 
Published: January 2023

Abstract
On the path to full understanding of the structure-function relationship or even design of RNA, structure prediction would offer an intriguing complement to experimental efforts. Any deep learning on RNA structure, however, is hampered by the sparsity of labeled training data. Utilizing the limited data available, we here focus on predicting spatial adjacencies (”contact maps”) as a proxy for 3D structure. We explore the space of self-supervised learning for RNA multiple sequence alignments and focus on downstream contact prediction from latent attention maps. Boosted decision trees in particular advance contact prediction quality and can be further enhanced by finetuning the pretrained backbone. Impressively, they double the precision of contact prediction/ reduce false
positives by a factor of five over the baseline. We name our model BARNACLE. Our conceptional advance could prove a breakthrough in decreasing the sequence-structure gap for RNA and is generalize-able to other tasks.
Valorization of banana and kinnow waste in the development of nutritional bar using extrusion and plate-molding technique
Authors: C Fazil , Kumar Yogesh , Sharma Rajiv , Srivast Tanuja , saxena DC 
Published: January 2023

Abstract
The banana pomace powder (BPF), banana peel powder (BPF), and kinnow peel powder (KPP) were characterized for their physicochemical, nutritional, and structural properties to produce extruded pellets and nutritional bar. Extruded pellets composed of 37% BPF as the base material, 25% jaggery, 25% BPP, 10% KPP, and 3% glycerol were characterized and further utilized to develop nutritional bars by plate-molding technique. It was found that nutritional bars formulated with higher water content were harder but had less cohesiveness and springiness. With a ponderated score of 15.53, the nutritional bar made with 15% water had the highest acceptability. The developed nutritional bar had an energy value similar to a commercial bar with low protein and fat content. However, it had a higher amount of crude fiber (15.14 g/100 g) and minerals such as potassium, calcium, iron, copper, and zinc, which could provide 29.11, 9.5, 40, 18, and 6% of the RDA recommendation, respectively. Conclusively, agro-industrial byproducts such as BPF, BPP, and KPP are good energy sources, and they are potential nutritional, functional, and cost-effective ingredients to develop functional foods like nutritional bars.
Seasonal variations, sources, and health risks of heavy metals in atmospheric PM 2.5 in Ulaanbaatar, Mongolia
Authors: Tugsbayan Bulgankhangai , Bolorerdene Khaliun , Ulziibat Bilguun , Tseren-Ochir Soyol-Erdene , Lee YiJi , Baldorj Barhasragchaa , Oyuntsetseg Bolormaa , Kim Yong Pyo , Natsagdorj Amgalan 
Published: January 2023

Abstract
To assess the seasonal variations, potential sources, and health risks of heavy metals in fine particulate matter (PM2.5), PM2.5 samples (n = 90) were collected between December 2019 and February 2022 in Ulaanbaatar, Mongolia. Fourteen metals (Al, Ti, Ca, Mg, Fe, As, Co, Sb, Ni, Ba, Cr, Cu, K, Mn, Pb) were determined by inductively coupled plasma mass spectrometer and inductively coupled plasma optic emission spectrometry (ICP-MS, ICP-OES). Results showed that the average annual mass concentration of the PM2.5 was 62.7 µg m–3 and 13.6 ± 4.2 µg m–3 at urban site in winter and summer, respectively. PM2.5 in winter exceeded the permissible limit in the Mongolian National Ambient Air Quality Standards (NAAQS, MNS4585:2016) for all days studied 1.1 to 4.6 times. The higher total concentrations of metals occurred in winter, whereas the lower concentrations were observed in summer with the winter to summer ratio of 12 (for summer)-1358 (for winter). Enrichment factor (EF) values high (> 100) indicated that the As, Sb, Cr, Cu, and Pb were mainly from combustion sources. Additionally, source apportionment by PCA identified three major sources for the studied metals: coal combustion, motor vehicles and resuspended dust of crustal source and ash particles. The carcinogenic risk (CR) of three heavy metals (As, Cr and Pb) in Ulaanbaatar exceeded the safe level (1 × 10-6) of exposure for both children and adults in winter, while within the limit of tolerable levels for summer.
Evaluation of the efficacy and safety of 3D printing porous titanium cage with non-window type versus window type in posterior lumbar interbody fusion: A prospective, randomized, multicenter trial study
Authors: Ham Dae-Woong , Park Sang-Min , Yang Jae Jun , Chang Dong-Gune , Kim Youngbae B , Lee Jeongik , Song Kwang-Sup 
Published: January 2023

Abstract
Trials guidance: The Abstract should not exceed 350 words. Please minimize the use of abbreviations and do not cite references in the abstract. The abstract must include the following separate sections:
• Background: No studies have compared the clinical outcome and radiographic outcome between window and non-window three-dimensional titanium (3D-Ti) cages. Therefore, well designed a randomized controlled trial (RCT) is needed. This multicenter, prospective RCT will compare the outcomes of window and non-window 3D-Ti cage in lumbar interbody fusion surgery.
• Methods: Study participants will be randomly assigned to the active intervention group or control intervention group in a 1:1 ratio and undergone a one-level posterior lumbar interbody fusion (PLIF) for degenerative lumbar disease. The window type 3D-Ti cage will be used in the participants assigned to the control intervention group. And the non-window type 3D-Ti cage will be used in the participants assigned to the active intervention. The clinical and radiographic outcomes between two groups will be compared serially until postoperative 12-months.
• Discussion: This trial designated for evaluating the equivalence of the clinical outcome between window and non-window 3D-Ti cage and will provide data on the effectiveness and safety of non-window type 3D-Ti cage.
• Trial registration: Clinical Research Information Service (cris.nih.go.kr) (KCT 0005793). Registered on 19 January 2021
Warming causes contrasting behavioral responses of predators by changing their prey size spectrum
Authors: Hu Xiaoli , Wu Xinwei , Zhou Qingping , Niklas Karl , Jiang Lin , Eisenhauer Nico , Reich Peter , Sun ShuCun 
Published: January 2023

Abstract
Global warming challenges predators by changing their abiotic and biotic environment. Although predators may adapt by virtue of behavioral plasticity, few studies have explored this behavior under field conditions. We conducted a field warming experiment in an alpine meadow using six large open-top chambers that increased mean annual temperature by 0.6°C. We monitored the abundance and behavior of two web-building spider species differing in size and their prey for four consecutive years. Warming reduced the prey biomass and decreased the abundance of short-bodied prey more than long-bodied ones for the larger spiders, and increased the abundance of long-bodied prey for the smaller spiders. As a consequence, warming reduced the abundance of the larger spider and increased the abundance of the small spider by an average of -47.4% and +128.3%, respectively. The web mesh-size of the larger spider decreased by -43.6%, whereas the mesh-size of the smaller spider increased by +79.8%. Structural equation models showed that the behavior of both spider species was the result of warming-induced changes in the prey size spectrum. Our data reveal that predators can behaviorally adapt to warming-induced shifts in the composition and size distribution of complex communities, which is likely to result in altered community metabolism, energy fluxes, and thus ecosystem functioning.
Aspirin and cancer survival-related pathways: a review and analysis of molecular mechanisms
Authors: Pandey Manoj , Rajput Monika , Singh Pooja , Shukla Mridula , Zhu Bin , Koshial Jill 
Published: January 2023

Abstract
Background: The benefit of aspirin on cancer survival is debated. Data from randomized clinical trials and cohort studies are discordant, although meta-analysis shows a clear survival advantage when aspirin is added to the standard of care. However, the mechanism by which aspirin improves cancer survival is not clear.
Methods: A PubMed search was carried out to identify articles reporting genes and pathways associated with aspirin and cancer survival. Gene ontology and pathway enrichment analysis was carried out using web-based tools. Gene-gene and protein-protein interactions were evaluated. Crosstalk between pathways was identified and plotted.
Results: Forty-one genes were identified and classified into primary genes (PTGS2 and PTGES2), genes regulating cellular proliferation, interleukin and cytokine genes and DNA repair genes. The network analysis showed a rich gene-gene and protein-protein interaction between these genes and proteins. Pathway enrichment showed the interleukin and cellular transduction pathways as the main pathways involved in aspirin-related survival, in addition to DNA repair, autophagy, extracellular matrix, and apoptosis pathways. Crosstalk of PTGS2 with EGFR, JAK/AKT, TP53, interleukin/TNFα/NFκB, GSK3B/BRCA/PARP, CXCR/MUC1, and WNT/CTNNB pathways was identified.
Conclusions: The results of present study demonstrate that aspirin improves cancer survival by the interplay of 41 genes through a complex mechanism. PTGS2 is the primary target of aspirin and impacts cancer survival through 6 primary pathways: the interleukin pathway, extracellular matrix pathway, signal transduction pathway, apoptosis pathway, autophagy pathway and DNA repair pathway.
WITHDRAWN: Identification of Lysosome-related Biomarkers for Predicting Prognosis and Immunotherapeutic Response in Breast Cancer
Authors: Zhang Jiwen , Wang Xiaofei , Duan Mingting , Zhang Zhongsheng , Jiang Meiping , Li Jing , Liu Xin , Ren Yun , Wang Yanhong , Jia Hongyan 
Published: January 2023

Abstract
Background
Breast cancer (BRCA) is one of the most frequent malignant tumors in women worldwide. Lysosomes are known to regulate tumor cell proliferation by manipulating growth factor signaling and providing nutrition. However, the role of lysosomes and lysosome-related genes (LRGs) in BRCA is yet unclear. Therefore, this study aimed to identify the lysosomal-related biomarkers for predicting the prognosis and immunotherapeutic response of BRCA.
Results
Based on the expression of 15 prognostic LRGs, BRCA cases were divided into two subtypes with significantly different overall survival (OS). In all, 537 differentially expressed lysosome-related genes (DELRGs) were identified and they were significantly enriched in the PI3K-Akt signaling pathway, protein digestion and absorption, and regulation of actin cytoskeleton. Then, the risk model was constructed based on five biomarkers, namely, QPRT, EIF4EBP1, IGJ, UGDH, and IL1R1. The Kaplan-Meier (K-M) and receiver operating characteristic (ROC) curves revealed that the risk model could accurately predict the prognosis of BRCA cases, and age, stage, and risk score were regarded as independent prognostic indicators. According to Gene set enrichment analysis (GSEA), the risk model might be related to the cell cycle, cytokine receptor interaction, and ATP synthesis coupled electron transport pathways. Moreover, the risk score showed significant positive correlation with CTLA4, while negative correlation with PD1. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) indicated the expression levels of EIF4EBP1 and UGDH were significantly higher in BRCA tissue compared with normal samples.
Conclusion
We identified two BRCA subtypes based on LRGs and constructed a risk model using five biomarkers. These findings may provide a theoretical basis and reference value for research and treatment in the direction of lysosomes in BRCA.
Mitigating Packet Dropping Nodes from MANETs due to System faults
Authors: P Venkat Reddy , Mohammad Arshad Ahmad Khan , D Rajani , Maddumala Venkata Rao , B Veeravasantharao , kantamneni Sravanthi 
Published: January 2023

Abstract
Self-forming and adaptation characteristics make MANETs suitable to deploy at places where Infrastructure is hard to set up. It consists of peer-to-peer mobile nodes with heterogeneous resources. Applications of the networks include healthcare, disaster recovery, and the military. The data present in these applications is susceptible. High-level security mechanisms are required to protect the data. One of the attacks present at the network layer in MANETs is packet dropping by the intermediatory node during the communication. The number of Mitigation mechanisms devised to focus on the issue but fail to differentiate packet dropping is due to malicious behavior of the node or system fault. Thus, the paper aims to develop a mechanism that mitigates the packet-dropping nodes from the communication path, whether due to system faults or malicious. The proposed work is validated with a network simulator. The results demonstrate that the proposed work achieved the most outstanding throughput compared to the current work.
Ethnomedical and ethnoveterinary use of Plantago sempervirens Crantz. A comparative study in Spain and the South of France
Authors: PARARD Priscilla , LIEUTAGHI Pierre , VIDAL-GONZÁLEZ Pablo 
Published: January 2023

Abstract
The plant Plantago sempervirens Crantz is very present in the East of the Iberian Peninsula, as well as in the Mediterranean regions of France (Languedoc, Provence and North Corsica). It is a plant that is hardly mentioned in the classical botanical literature and we hardly have any references to its ethno-veterinary uses. However, popular tradition points to important anti-inflammatory uses, as well as for healing wounds, among other uses. To find out whether the lack of information was due to a lack of use or rather a gap in the research on the plant, semi-structured interviews were conducted in both France and Spain, as well as an exhaustive bibliographic review done. Intense field work has been carried out both in France and Spain, conducting semi-structured interviews with informants, mainly elderly people, to learn about the ethnomedicinal and ethnoveterinary uses of the plant, in the absence of solid bibliographical references. Main uses were associated with the healing of inflammations and wounds as well as a disinfectant for animals. There is a strong contrast between the important presence in the oral tradition in Spain and the local one in France, which allows us to propose an export of popular knowledge beyond the Pyrenees. The above-mentioned uses have ceased in the vast majority of cases.