bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor Penyebab Infeksi Masa Nifas
Authors: Idyawati Susilia 
Published: May 2023

Infeksi nifas merupakan salah satu faktor penyebab kematian ibu, diperkirakan kematian ibu diakibatkan kehamilan setelah persalinan dan pada masa nifas dalam 24 jam pertama. Penelitian ini bertujuan untuk mengetahui faktor penyebab infeksi pada masa nifas. Metode Penelitian studi literature review didapatkan 10 artikel yang selanjutnya akan direview. Berdasarkah hasil dari 10 artikel yang dipilih untuk review di Negara-negara yang ada di Benua Afrika seperti Kenya, Ethiopia, Kamerun dan Nepal didapatkan faktor penyebab terjadinya infeksi masa nifas berdasarkan hasil penelitian disebabkan karena faktor langsung dan faktor yang tidak langsung. Faktor langsung penyebab infeksi nifas yaitu karena pemeriksaan dalam (VT) yang terlalu sering partus lama, proses persalinan kala 2 dengan sectio sesaria, setelah masa nifas yang disebabkan karena personal higine yang rendah penyebab tidak langsung dari infeksi berdasarkan hasil review yaitu tempat tinggal, tingkat pendidikan, pengetahuan, ketersediaan makanan, tempat bersalin IMT, riwayat kunjungan antenatal care, riwayat diabetes mellitus dan anemia. Dapat disimpulkan Faktor Penyebab Infeksi Masa nifas terdiri dari Penyebab Langsung dan Tidak langsung.
Comparison of long-term outcome in patients with calcified stenosis treated with intravascular lithotripsy or with modified balloon angioplasty: a propensity score-adjusted study
Authors: Leick Jürgen , Rheude Tobias , Denne Michael , Cassese Salvatore , Kastrati Adnan , Hauptmann Felix , Gehrig Thomas , Kuna Constantin , Lindner Michael , Lauterbach Michael , Werner Nikos 
Published: May 2023

BackgroundThe aim of this two-center, all-comers registry was to compare the effectiveness and safety of intravascular lithotripsy (IVL) to that of modified balloon angioplasty (MB). MB angioplasty using a cutting or scoring balloon is commonly used in patients with calcified coronary arteries. IVL is a new technology for lesion preparation. This is the first study to compare MB with IVL.MethodsThe cohort included all patients treated by MB angioplasty or IVL between 2019 and 2021. The primary endpoint was strategy success (&lt;20% residual stenosis). The secondary endpoint was long-term safety outcomes [cardiac death, acute myocardial infarction (AMI), target lesion failure/revascularization (TVR)]. Quantitative coronary angiography (QCA) was performed in all patients. Primary and secondary endpoints were compared using inverse probability of treatment weighting (IPTW) for treatment effect estimation.ResultsA total of n = 86 patients were treated by IVL and n = 92 patients by MB angioplasty. The primary endpoint was reached in 152 patients (85.4%). Patients in the IVL group had less residual stenosis (5.8% vs. 22.8%; p = 0.001) in QCA. Weighted multivariable regression analysis revealed that IVL had a significant positive effect on reaching the primary endpoint of strategy success [odds ratio (OR) 24.58; 95% confidence interval (95% CI) 7.40–101.86; p = 0.001]. In addition, severe calcification was shown to result in a lower probability of achieving the primary endpoint (OR 0.08; 95% CI 0.02–0.24; p = 0.001). During the follow-up period (450 days) there was no difference in cardiovascular mortality rate [IVL (n = 5) 2.8% vs. MB (n = 3) 1.7%; p = 0.129]. Patients with unstable angina at the time of the index procedure had the highest probability of cardiovascular death [hazard ratio (HR) 7.136; 95% CI 1.248–40.802; p = 0.027]. No differences were found in long-term rates of AMI (IVL 1.7% vs. MB 2.8%; p = 0.399; IVL HR 2.73; 95% CI 0.4–17.0; p = 0.281) or TVR (IVL 5.6% vs. MB 9%; p = 0.186; IVL HR 0.78; 95% CI 0.277–2.166; p = 0.626).ConclusionIVL leads to a significantly better angiographic intervention outcome compared to MB angioplasty in our cohort. During long-term follow-up, no differences in cardiovascular mortality, rate of acute myocardial infarction, or target lesion failure/revascularization were observed.
Building the foundation for a modern patient-partnered infrastructure to study temporomandibular disorders
Authors: Gressler Laura Elisabeth , Cowley Terrie , Velezis Marti , Aryal Suvekshya , Clare Deanne , Kusiak John W. , Cowley Allen W. , Sedrakyan Art , Marinac-Dabic Danica , Reardon Michelle , Schmidt Lisa , Feldman Jennifer Ginsburg , DiFabio Vincent , Bergman Suzie , Simonyan Vahan , Yesha Yelena , Vasiliu-Feltes Ingrid , Durham Justin , Steen Andrew I. , Woods Phillip , Kapos Flavia P. , Loyo-Berrios Nilsa 
Published: May 2023

BackgroundConflicting reports from varying stakeholders related to prognosis and outcomes following placement of temporomandibular joint (TMJ) implants gave rise to the development of the TMJ Patient-Led RoundTable initiative. Following an assessment of the current availability of data, the RoundTable concluded that a strategically Coordinated Registry Network (CRN) is needed to collect and generate accessible data on temporomandibular disorder (TMD) and its care. The aim of this study was therefore to advance the clinical understanding, usage, and adoption of a core minimum dataset for TMD patients as the first foundational step toward building the CRN.MethodsCandidate data elements were extracted from existing data sources and included in a Delphi survey administered to 92 participants. Data elements receiving less than 75% consensus were dropped. A purposive multi-stakeholder sub-group triangulated the items across patient and clinician-based experience to remove redundancies or duplicate items and reduce the response burden for both patients and clinicians. To reliably collect the identified data elements, the identified core minimum data elements were defined in the context of technical implementation within High-performance Integrated Virtual Environment (HIVE) web-application framework. HIVE was integrated with CHIOS™, an innovative permissioned blockchain platform, to strengthen the provenance of data captured in the registry and drive metadata to record all registry transaction and create a robust consent network.ResultsA total of 59 multi-stakeholder participants responded to the Delphi survey. The completion of the Delphi surveys followed by the application of the required group consensus threshold resulted in the selection of 397 data elements (254 for patient-generated data elements and 143 for clinician generated data elements). The infrastructure development and integration of HIVE and CHIOS™ was completed showing the maintenance of all data transaction information in blockchain, flexible recording of patient consent, data cataloging, and consent validation through smart contracts.ConclusionThe identified data elements and development of the technological platform establishes a data infrastructure that facilitates the standardization and harmonization of data as well as perform high performance analytics needed to fully leverage the captured patient-generated data, clinical evidence, and other healthcare ecosystem data within the TMJ/TMD-CRN.
Impact of continuous glucose monitoring on glycemic control and its derived metrics in type 1 diabetes: a longitudinal study
Authors: Cho So Hyun , Kim Seohyun , Lee You-Bin , Jin Sang-Man , Hur Kyu Yeon , Kim Gyuri , Kim Jae Hyeon 
Published: May 2023

AimWe explored the effectiveness of continuous glucose monitoring for 1 year on glycated A1c reduction in adults with type 1 diabetes mellitus.MethodsWe included type 1 diabetes mellitus adults who were either new continuous glucose monitoring users (N = 155) or non-users who were under standard care (N = 384). Glycated A1c was measured at baseline and 3, 6, 9, and 12 months. Individuals with (N = 155) or without continuous glucose monitoring use (N = 310) were matched 1:2 by propensity score. We used the linear mixed models to identify the quantitative reduction in repeated measures of glycated A1c.ResultsThe change in glycated A1c from baseline to 12 months was −0.5% ± 1.0% for the continuous glucose monitoring user group (N = 155, P &lt; 0.001) and −0.01% ± 1.0% for the non-user group (N = 310, P = 0.816), with a significant difference between the two groups (P = 0.003). Changes in glycated A1c were significant at 3, 6, 9, and 12 months compared with those at baseline in patients using continuous glucose monitoring (P &lt; 0.001), and the changes differed significantly between the groups (P &lt; 0.001). A linear mixed model showed an adjusted treatment group difference in mean reduction in glycated A1c of −0.11% (95% confidence interval, −0.16 to −0.06) each three months. In the continuous glucose monitoring user group, those who achieved more than 70% of time in range significantly increased from 3 months (37.4%) to 12 months (48.2%) (P &lt; 0.001).ConclusionIn this longitudinal study of type 1 diabetes mellitus adults, the use of continuous glucose monitoring for 1 year showed a significant reduction in glycated A1c in real-world practice.
Molecular diagnosis and genotyping of Orientia tsutsugamushi in Maesot and Chiangrai, Thailand
Authors: Rungrojn Artharee , Batty Elizabeth M. , Perrone Carlo , Abdad Mohammad Yazid , Wangrangsimakul Tri , Brummaier Tobias , McGready Rose , Day Nicholas P. J. , Blacksell Stuart D. 
Published: May 2023

IntroductionScrub typhus is a neglected tropical disease with an estimated 1 million cases annually. The Asia-Pacific region is an endemic area for scrub typhus, especially in Thailand.MethodsBetween June 2018 and December 2019, 31 patients with acute undifferentiated febrile illness (AUFI) were recruited for clinical trials and tested positive by a scrub typhus IgM RDT.ResultsOf the 17 buffy coat patient samples tested by 47kDa real-time PCR and 56kDa type-specific antigen (TSA) nested PCR, 94% (16/17) were positive, and of the 11 patients that presented with eschar lesions, 100% (11/11) of the eschar samples were confirmed positive. Genetic analysis of the 560 bp partial 56-kDa TSA gene demonstrated that most Orientia tsutsugamushi (Ot) infections were with Karp, Gilliam, Taiwan, P23, and CM606-like strains.DiscussionThis is the second occasion that the CM606-like and P23-like strains were reported in northern Thailand (first reported in 2011 and 2013, respectively). This study demonstrates that 1) the eschar remains the most reliable biological sample for PCR diagnosis of scrub typhus and 2) Northwestern Thailand has significant diversity of Ot strains, which underlines the requirement for ongoing surveillance to increase our understanding of Ot diversity to ensure accurate diagnostics and treatment.
Comparative genomics reveal distinct potential of Tamlana sp. S12 for algal polysaccharide degradation
Authors: Xia Hai-Feng , Jia Xiao-Yu , Zhou Yan-Xia , Du Zong-Jun , Mu Da-Shuai , Chen Guan-Jun 
Published: May 2023

IntroductionMacroalgae contain various polysaccharides that serve as nutrient sources Introduction: Macroalgae contain various polysaccharides that serve as nutrient sources for marine bacteria. Carbohydrate-active enzymes (CAZymes) are the primary feature of marine bacteria that utilize these polysaccharides. In this study, we describe Tamlana sp. S12, a novel strain of marine flavobacteria that can degrade alginate and Laminaria japonica biomass, isolated from the intestines of the sea cucumber Apostichopus japonicas collected at Weihai coast.MethodsWe sequenced the entire genome of strain S12 and constructed a phylogenetic tree using the core genome sequences of related strains. We determined the enzymatic activity of strain S12 using the DNS method and measured its growth curve under different carbon sources using spectrophotometry.ResultsStrain S12 degraded dehydrated L. japonica fragments as the sole nutrient source within 48h. Strain S12 harbors a diverse array of CAZymes at multiple polysaccharide utilization loci (PUL). One PUL encoding lyases from PL6, 7, and 17 families may be used for the degradation of alginate. Additionally, strain S12 harbors PULs encoding carrageenan- and agar-targeting CAZymes. Comparative analysis with related flavobacteria from Algibacter, Maribacter, and Zobellia showed shared CAZymes among these strains, potentially derived from a common ancestor and stably maintained within strains. Genomic signatures, algal degradation ability, and CAZyme patterns suggest that strain S12 has the potential to degrade complex algal polysaccharides.ConclusionThese results expand our knowledge of CAZymes and enrich our understanding of how marine Flavobacteriaceae adapt to marine algal polysaccharide environments. The availability of the genome of Tamlana sp. S12 will be beneficial for further analyses of marine Flavobacteriaceae.
Effects of ambient humidity and sintering temperature on the tribological and antistatic properties of PEEK and CF/PEEK
Authors: Pang Xianjuan , Yue Shiwei , Huang Suling , Xie Jinmeng , Wang Shuai , Yue Yun , Song Chenfei , Li Dong 
Published: May 2023

Polyether ether ketone (PEEK) is one of the representatives of special engineering plastics. Due to the high molding temperature, the molding method of ordinary plastics and cavity abrasives are difficult to meet the requirements. In view of this, pure PEEK was prepared by vacuum hot pressing sintering technology at different sintering temperatures. The mechanical properties and microstructure characterization results showed that the pure PEEK prepared at 350 °C showed excellent friction and wear properties. Then PEEK and CF/PEEK composites were prepared at the optimum sintering temperature. The friction experiments of prepared materials were carried out using UMT-2. The effects of ambient humidity on the tribological properties, wear mechanism and antistatic properties of prepared materials were systematically studied. The surface analysis and properties of the materials were measured by 3D profiler, scanning electron microscope, friction electrostatic tester. The results showed that friction coefficient of PEEK and CF/PEEK composite changed slightly with increase of ambient humidity. The wear rate of PEEK decreased firstly and then increases, which reached the lowest of 3.09 × 10−5 mm3/Nm when the ambient humidity was 40%. The wear rate of CF/PEEK composite changed slightly, which was significantly lower than that of PEEK, and the main wear mechanism was adhesive wear. The surface friction static electricity of PEEK and CF/PEEK composites decreased with the increase of humidity.
Comprehensive analysis to construct a novel immune-related prognostic panel in aging-related gastric cancer based on the lncRNA‒miRNA-mRNA ceRNA network
Authors: Deng Cuncan , Peng Juzheng , Yuan Cheng , Li Huafu , Li Wenchao , Chu Hongwu , Wei Hongfa , He Yulong , Zeng Leli , Huo Mingyu , Zhang Changhua 
Published: May 2023

Introduction: Gastric cancer (GC) is the fifth frequent malignancy and is responsible for the third leading cause of cancer-related deaths. Gastric cancer is an aging-related disease, with incidence and mortality rates increasing with aging. The development of GC is affected by lncRNAs, miRNAs, and mRNAs at the transcriptional and posttranscriptional levels. This study aimed to establish a prognostic panel for GC based on competing endogenous RNA (ceRNA) networks.Methods: RNA sequences were obtained from the TCGA database. Different expressions of RNAs were scrutinized with the EdgeR package. The ceRNA network was built using the starBase database and the Cytoscape. The prognostic panel was constituted with the LASSO algorithm. We developed a nomogram comprising clinical characteristic and risk score. The receiver operating characteristic (ROC) was used to evaluate the accuracy of the nomogram prediction. Hub RNAs expressions were detected by qPCR, immunohistochemistry and western blot respectively. Clinical relevance and survival analyses were analyzed. The relationship between RNAs and immune infiltrations, as well as immune checkpoints, was analyzed and evaluated using the CIBERSORT, TIMER and TISIDB databases.Results: Four DElncRNAs, 21 DEmiRNAs and 45 DEmRNAs were included in the ceRNA network. A 3-element panel (comprising lncRNA PVT1, hsa-miR-130a-3p and RECK) with poor overall survival (OS) was established and qPCR was applied to validate the expressions of hub RNAs. Hub RNAs were firmly associated with T, M, and N stage. The CIBERSORT database showed that the high lassoScore group exhibited a significantly high ratio of resting memory CD4+ T cells, M2 macrophages and a significantly low ratio of activated memory CD4+ T cells and M1 macrophages. According to the TIMER database, this panel was linked to immune infiltrations and immune cell gene markers. TISIDB database indicated that RECK was positively correlated with immune checkpoints (including CD160, CD244, PDCD1, and TGFBR1).Discussion: A novel triple prognostic panel of GC constructed based on the ceRNA network was associated with clinical prognostic, clinicopathological features, immune infiltrations, immune checkpoints and immune gene markers. This panel might provide potential therapeutic targets for GC and more experimental verification research is needed.
A randomized controlled trial of preemptive rituximab to prevent recurrent focal segmental glomerulosclerosis post-kidney transplant (PRI-VENT FSGS): protocol and study design
Authors: Rheault Michelle N. , Amaral Sandra , Bock Margret , Chambers Eileen Tsai , Chavers Blanche , Ters Mireile El , Garro Rouba , Gbadegesin Rasheed , Govil Amit , Harshman Lyndsay , Amer Hatem , Hooper David K. , Israni Ajay K. , Riad Samy , Sageshima Junichiro , Shapiro Ron , Seifert Michael , Smith Jodi , Sung Randall , Thomas Christie P. , Wang Qi , Verghese Priya S. 
Published: May 2023

BackgroundFocal segmental glomerulosclerosis (FSGS) is a common cause of end-stage kidney disease requiring kidney transplantation and can recur in the allograft in 30-80% of recipients resulting in reduced graft survival. Plasmapheresis has shown efficacy in treating some cases of recurrent FSGS but isolated plasmapheresis has not demonstrated efficacy in preventing recurrent FSGS. Rituximab has had anecdotal success in preventing recurrence in a single center study but has not been studied in combination with plasmapheresis for preventing FSGS recurrence.MethodsWe are conducting a randomized, controlled, multicenter clinical trial of adult and pediatric kidney transplant recipients with primary FSGS to assess whether plasmapheresis in combination with rituximab prevents recurrent disease post-transplantation.DiscussionRituximab combined with plasmapheresis is a promising, novel therapy to prevent recurrent FSGS, a disease with limited therapeutic options and no consensus guidelines for prevention or treatment.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/NCT03763643, identifier NCT03763643.
Case Report: Long-term survival of a patient with advanced rectal cancer and multiple pelvic recurrences after seven surgeries
Authors: Ouyang Ye , Zhu Yilin , Chen Haoyi , Li Guoquan , Hu Xiongwei , Luo Hongyu , Li Zhou , Han Shuai 
Published: May 2023

BackgroundRectal cancer has a high risk of recurrence and metastasis, with median survival ranging from 24 months to 36 months. K-RAS mutation is a predictor of poor prognosis in rectal cancer. Advanced rectal cancer can be stopped in its tracks by pelvic exenteration.Case summaryA 51-year-old woman was diagnosed with advanced rectal cancer (pT4bN2aM1b, stage IV) with the KRAS G12D mutation due to a change in bowel habits. The patient had experienced repeated recurrences of rectal cancer after initial radical resection, and the tumor had invaded the ovaries, sacrum, bladder, vagina and anus. Since the onset of the disease, the patient had undergone a total of seven surgeries and long-term FOLFIRI- or XELOX-based chemotherapy regimens, with the targeted agents bevacizumab and regorafenib. Fortunately, the patient was able to achieve intraoperative R0 resection in almost all surgical procedures and achieve tumor-free survival after pelvic exenteration. The patient has been alive for 86 months since her diagnosis.ConclusionsPatients with advanced rectal cancer can achieve long-term survival through active multidisciplinary management and R0 surgery.
Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy
Authors: Huang Jia-Jia , Zou Zhi-Ye , Zhou Zhi-Peng , Liu Yan , Yang Zhen-Jia , Zhang Jing-Jing , Luan Ying-Yi , Yao Yong-Ming , Wu Ming 
Published: May 2023

Background: This study aimed to investigate whether early unfractionated heparin (UFH) administration provides a survival advantage for patients with sepsis-induced coagulopathy (SIC).Methods: Patients hospitalized with sepsis-induced coagulopathy from the Medical Information Mart for Intensive Care (MIMIC)-IV database were identified. Patients were divided into two groups, who received unfractionated heparin (UFH) subcutaneously within 24 h after intensive care unit (ICU) admission, and the control group, who received not. The primary endpoint was intensive care unit mortality, the secondary outcomes were 7, 14, and 28-day and hospital mortality. Propensity score matching (PSM) the marginal structural Cox model (MSCM) and E-value analysis were used to account for baseline differences, time-varying and unmeasured confounding factors.Results: A total of 3,377 patients with sepsis-induced coagulopathy were enrolled in the study, of which 815 in unfractionated heparin group and 2,562 in control group. There was significant effect on primary and secondary outcomes with unfractionated heparin after propensity score matching (intensive care unit mortality, hazard ratio [HR] 0.69, 95% confidence interval [CI] 0.52–0.92; 7-day, HR 0.70, 95% CI 0.49–0.99; 14-day, HR 0.68.95% CI 0.50–0.92; 28-day, HR 0.72, 95% CI 0.54–0.96; hospital mortality, HR 0.74, 95% CI 0.57–0.96), marginal structural Cox model manifested unfractionated heparin associated with decreased intensive care unit mortality in all populations (HR 0.64, 95% CI 0.49–0.84), and stratification with the marginal structural Cox model indicated analysis further indicated the survival advantage only among patients with an sepsis-induced coagulopathy score of 4 (HR 0.56, 95% CI 0.38–0.81). Further analysis showed that treatment with 6,250–13750 IU/day of unfractionated heparin associated with a decreased risk of intensive care unit mortality. Similar results were replicated in subgroup analysis with propensity score matching only for patients with an sepsis-induced coagulopathy score of 4 (intensive care unit mortality, HR 0.51, 95% CI 0.34–0.76).Conclusion: This study found early unfractionated heparin therapy to patients with sepsis-induced coagulopathy appears to be associated with improved outcomes. Subgroup analysis further demonstrates heparin therapy decreased intensive care unit mortality primarily in patients only with SIC score of 4.