bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly efficient, stable, and easily detachable cellulose based membrane system inspired by water hyacinth
Authors: Zhang Fang , Sun Yuxin , Qian Xinye , Tan Xiaoyan , Liu Peipei , Yao Zhong , Zheng Chunling , Hu Yonghong 
Published: July 2023

Abstract
A rapid extracted and concentrated system engineered by green polymers is attractive but there is still a challenge with respect to both materials and processes. Water hyacinth root cells have evolved as a biological membrane system that can transport and concentrate metal ions from water to the plant body rather than simply utilizing the intrinsic trapping properties of cellulose/lignin. This has inspired a novel biological membrane system (BMS), namely, a porous nanocellulose/lignin microdevice (NLMD) accommodated with a stripping agent that is dispersed in an organic phase. In practice, in water, metal ions can be efficiently transported through an organic membrane phase and finally locked in the NLMD, as demonstrated by extraction efficiency (3 min, ~ 90%), as well as high-enrichment (~ 27 times) toward Pb, Zn, and Cu ions. The NLMD was fabricated using nanocellulose and reinforced using lignin–polyamide epoxy chloropropane nanoaggregates that endow the high mechanical stability and good W/O interfacial affinity of the NLMD. Significantly, the BMS could be facilely detached via simple filtration and shape recovery, offering a high-performance and facile regeneration pathway that are hardly attainable by the conventional cellulose-based adsorbents.
Asthma and COPD management of patients with intellectual disabilities in Dutch general practice
Authors: Mastebroek Mathilde , Everlo Nadeem , Cuypers Maarten , Bischoff Erik , Schalk Bianca 
Published: July 2023

Abstract
People with intellectual disabilities (ID) experience overall poorer health and healthcare access than the general population. It is largely unknown how this applies to asthma and chronic obstructive pulmonary disease (COPD) management by general practitioners (GPs). In a ten-year retrospective matched cohort study, n = 34,429, we examined year prevalence of asthma and COPD in adult patients with and without ID and potential differences in the delivery of asthma and COPD disease management activities in Dutch general practices (2010–2019). We collected information on patient characteristics, comorbidity, consultation patterns, use and outcomes of asthma/COPD control questionnaires, spirometry measurement, pulmonology referrals, and prescribed medication. Asthma patients with ID suffered more frequently from obesity (53.2% vs. 39.5% without ID), and both asthma and COPD patients with ID were more frequently current smokers (45.2% vs. 22.1% without ID and 76.6% vs. 51.4% without ID, respectively). Compared with controls, the asthma patients with ID group received overall about twice the median number of practice consultations (42 vs. 23) and telephone consultations (16 vs. 8), and a statistically significant larger number of patients were prescribed antibiotics (69.9% vs. 54.5%). The asthma year point prevalence in patients with ID was, from 2014 onward, significantly higher (8.7% vs. 6.0% in 2019). For COPD, it was comparable in both groups. However, both asthma and COPD patients with ID appeared considerably younger in age than non-ID patients. Our findings warrant further research into the causes of the differences found for asthma and COPD and whether they also infer differences in the quality or the effectiveness of GP disease management, especially for young adults with ID.
Regenerating tropical forests are consistently affected by biological invasions across spatial scales
Authors: Zardetto Juliano , Siqueira Tadeu 
Published: July 2023

Abstract
Biological invasions are complex scale-dependent processes. Metacommunity ecology provides the means to understand the effects of invasive non-native species (INNS) because it explicitly considers how local and regional processes interact to drive the three main components of biodiversity: alpha, beta, and gamma. White-popinac (Leucaena leucocephala (Lam.) de Wit) is a widely distributed INNS in regenerating forests in the Atlantic Forest (Brazil). White-popinac invasions results in a particular spatial structure as the species forms dense and homogeneous patches, instead of spreading individuals throughout invaded areas. Here we took advantage of this unique spatial configuration formed by patches of native forest, regenerating areas, and patches of white-popinac to investigate how local and regional dynamics of plant (meta-)communities under natural regeneration are affected by white-popinac. We conducted replicated multi-strata surveys in 131 communities distributed among 29 meta-communities of regenerating forests that had different ages of white-popinac invasion. We found (i) mirrored responses among local and regional scales: at both scales, native species richness decreased with the increase of invasion age, whereas INNS richness increased; and (ii) β-diversity of native species decreased with the increase of invasion age, showing that time-advance of invasion led to a homogenizing effect. We also found evidence that the advance of white-popinac patches towards regenerating forests increases with time and proximity to the forest fragment, which likely had indirect effects on regenerating communities by reducing the size of the regenerating area. Our results indicate that the effects of white-popinac invasions on regenerating forests can be so vigorous that they propagate from the local to the regional scale, via a decrease in β-diversity. We reinforce the importance of considering multiscale approaches on assessing effects of white-popinac invasions.
Clustering Method for Time-Series Images Using Quantum-Inspired Computing Technology
Authors: Matsuda Yu , Inoue Tomoki , Kubota Koyo , Ikami Tsubasa , Egami Yasuhiro , Nagai Hiroki , Kashikawa Takahiro , Kimura Koichi 
Published: July 2023

Abstract
Time-series clustering is a powerful data mining technique for time-series data in the absence of prior knowledge about the clusters. This study proposes a novel time-series clustering method that leverages a simulated annealing machine, which accurately solves combinatorial optimization problems. The proposed method facilitates an even classification of time-series data into clusters close to each other while maintaining robustness against outliers. We compared the proposed method with a standard existing method for clustering an online distributed dataset and found that both methods yielded comparable results. Furthermore, the proposed method was applied to a flow measurement image dataset containing noticeable noise with a signal-to-noise ratio of approximately 1. Despite a small signal variation of approximately 2%, the proposed method effectively classified the data without any overlap among the clusters. In contrast, the clustering results by the standard existing methods displayed overlapping clusters. These results indicate the effectiveness of the proposed method.
Development of ZnO Adorned Glassy Carbon Electrode for Voltammetric Sensing and Electro-Kinetic Investigations of Antihypertensive Drug Efonidipine
Authors: Agarwal Rinky , Jhankal Deependra , Yadav Rajesh , Sharma D K , Jhankal Krishna 
Published: July 2023

Abstract

The fast, accurate, and affordable determination of efonidipine (EFO) is the need of the time for human mental health. In this work, we proposed a ZnO-adorned glassy carbon electrode (ZnO/GCE) for the voltammetric sensing and electro-kinetic investigations of efonidipine in pharmaceutical samples. ZnO-decorated glassy carbon electrode exhibit enhanced electro-catalytic activity, higher surface area, rapid electron transfer rate, and enhanced electrical conductivity, these properties result in an amplified peak current response for the electro-reduction of EFO. The ZnO nanoparticles are synthesized by a simple and economical sol-gel method and characterized by XRD, SEM, and EDS techniques. The electro-kinetic studies of efonidipine on the ZnO fabricated glassy carbon electrode was investigated using CV, EIS, LSV, DPSV, and Chronocoulometry techniques. The diffusion-controlled electro-reduction of EFO produced three well-defined peaks in the cyclic voltammograms. The various electro-kinetics parameters like diffusion coefficient (Do), heterogeneous rate constant (Kh), electron transfer coefficient (α), and surface coverage (Γ) were evaluated and the mechanism of electro-reduction was proposed. The peak current in LSV and DPSV techniques shows a linear relationship with the concentration of EFO in the range of 0.14–0.98 µmolL− 1 with detection limits of 0.21 and 0.07 µmolL− 1, respectively. The proposed ZnO/GCE sensor demonstrates a cost-effective and environmentally compatible approach for the detection of efonidipine in pharmaceutical samples.
Anti-α-glucosidase, anti-proliferative and anti-enterovirus 71 activity of secondary metabolites identified from Grifola frondosa
Authors: He Junqiang , Xiong Wenyu , Zhao Lina , Liu Bin , Huang Ying 
Published: July 2023

Abstract
Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G. frondosa by chromatographic column. Among the isolated compounds, heptadecanoic acid, uridine and adenosine exhibited potent inhibition activity against α-glucosidase, ergosterols and ergosterol−5,8-peroxide showed anti-proliferative activity on tumor cells, while ergosterol and methyl linoleate displayed inhibition against the replication of EV71. Also, to our knowledge, this is the first study to report that fatty acids in G. frondosa showing potent inhibition against α-glucosidase and EV71. Further molecular docking results revealed that the active compounds in G. frondosa form hydrogen bonding, hydrophobic interactive and π-stacking with the active sites on the surface of α-glucosidase, CASP3 and VP1 proteins, thus promoting the active compounds to combine with the target protein to form a stable complex, thus playing an antagonistic role. Our results provide a new active compound and mode of action for G. frondosa to treat diabetes, cancer and EV71-infected patients.
Understanding Touchscreen-based Image Exploration for Screen Reader Users
Authors: Joh Hwayoen , Lee Yunjung , Park Sohyeon , Oh Uran 
Published: July 2023

Abstract
Recently, researchers have studied improving the accessibility of image exploration for peoplewith visual impairments. While most of the studies haveworked on making a tactile version of an image or providing audio feedback upon touch, it is still difficult to find and locate specific elements, particularly when thesize of the target is small. In this paper, we focusedon investigating how screen reader users interact withsmall items on an image on touchscreen devices. Withthis goal, we conducted a single-session user study with 12 participants who are screen reader users where theywere asked to share their prior experience with zoomfunctionality and map applications, try an existing mapapplication, and perform image exploration tasks withthree different exploration techniques. Findings suggest that providing a hint on which cell the item is locatedwhen the screen is divided into 2 × 2 grid and zoomfunction were considered helpful during the exploration.Based on the findings, we share implications for mak-ing image exploration task more accessible for screenreader users.
Hysteroscopy in the new media: quality and reliability analysis of hysteroscopy procedures on YouTubeTM.
Authors: Libretti Alessandro , Vitale Salvatore Giovanni , Saponara Stefania , Corsini Christian , Aquino Carmen Imma , Savasta Federica , Tizzoni Eleonora , Troia Libera , Surico Daniela , Angioni Stefano , Remorgida Valentino 
Published: July 2023

Abstract
Background
Hysteroscopy plays a crucial role in diagnosing and managing various intrauterine pathologies. However, its execution can be influenced by patients' perception and understanding, which are often shaped by digital resources such as YouTube™. Given its popularity and accessibility, YouTube™ has the potential to greatly influence patients' knowledge and expectations about this procedure, highlighting the need for accurate and reliable information.
Purpose
This study aims to assess the reliability and quality of hysteroscopy information available to patients on YouTube™. Understanding the nature of information patients’ access can help address their fears and potential misunderstandings about the procedure, consequently reducing the likelihood of suspension or postponement due to anxiety.
Methods
A comprehensive analysis of YouTube™ was conducted, simulating the search process of a patient seeking information about hysteroscopy. The study evaluated the reliability and quality of 90 out of the first 100 hysteroscopy-related videos on YouTube™, scored by four gynecologists – two experienced hysteroscopists and two trainees. The videos were assessed for reliability and quality using the mDISCERN and Global Quality Scale (GQS) scores.
Results
The average mDISCERN and GQS scores for the evaluated videos were below the optimal 3 points, highlighting the lack of fluency, comprehensiveness, and reliability of the available information. Notably, while videos produced by experts, including doctors and professional channels, had higher scores, they still fell short of the minimum score of 3. These videos also weren't considered more suitable for either patients or trainees. Videos that were assessed as reliable (mDISCERN ≥ 3) were observed to be longer and were more frequently produced by doctors. These videos were suggested more to trainees rather than patients. Similarly, videos deemed as fluent and comprehensive (GQS ≥ 3) were longer and were more often recommended to patients.
Conclusions
While YouTube™ is a widely used source of medical information, the quality and reliability of hysteroscopy videos on the platform are poor. The strategic use of selected, high-quality hysteroscopy videos can enhance procedure success and alleviate patient fears. However, the unsupervised discovery of information by patients could potentially lead to procedure failure or an elevated level of stress due to misleading or incorrect information.
Unveiling the Molecular Landscape: Network Analysis of Genes, Proteins, and Transcription Factors in Primary Progressive and Secondary Progressive Multiple Sclerosis for Unraveling Disease Progression and Prognostic Factors
Authors: Sharifi Armin , Radak Mehran , Mohamadi Hossein , Fallahi Hossein , Rahimi Zohreh 
Published: July 2023

Abstract
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the destruction of the myelin sheath in the central nervous system (CNS), leading to various neurological symptoms. The disease has different types, including relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS), and progressive-relapsing MS (PRMS), each with its own clinical characteristics and prognosis. The exact cause of MS is not known, but it is believed to result from a complex interaction between genetic and environmental factors. This study offers a comprehensive analysis of individuals with varying disease durations in multiple sclerosis, comparing those who experienced earlier mortality with those who lived longer. By elucidating the factors influencing disease progression and severity, we anticipate that our findings will contribute to the advancement of knowledge in the field, with the potential to inform future research and clinical practices aimed at improving patient outcomes in MS. In this study, we used microarray data from postmortem brain tissue samples available from NCBI and used a system biology approach to identify differentially expressed genes (DEGs) associated with PPMS and SPMS. We performed protein-protein interaction (PPI) network analysis to identify common proteins and modules involved in the pathogenesis of the two diseases. Additionally, we analyzed the interaction between transcription factors (TFs) and DEGs to identify potential regulatory mechanisms. Furthermore, gene ontology analysis was conducted to investigate the biological processes and pathways affected by the DEGs. Our analysis identified a total of 153 common DEGs between PPMS and SPMS. These DEGs were involved in various biological processes such as cell adhesion, regulation of apoptotic process, inflammatory response, and protein phosphorylation. The PPI network analysis revealed key proteins, including MSN, ROS1, CD4, and NR4A1, which may play important roles in the pathogenesis of both diseases. We also identified TFs that interacted with the DEGs, highlighting their potential regulatory roles. Our study provides insights into the molecular mechanisms underlying PPMS and SPMS. By identifying common DEGs, PPIs, and TFs, we contribute to the understanding of shared pathways and potential therapeutic targets for these neurodegenerative disorders. Further research is warranted to validate and explore the functional significance of these findings.
Monitoring of sepsis by HNL Dimer in plasma and the comparison with current biomarkers
Authors: Venge Per , Peterson Christer , Xu Shengyuan , Larsson Anders , Johansson Joakim , Tydén Jonas 
Published: July 2023

Abstract
Sepsis is a growing problem worldwide and associated with high mortality and morbidity. The early and accurate diagnosis and effective supportive therapy are critical for combating mortality. The aim of the study was to compare the kinetics of four biomarkers in plasma in patients admitted to ICU including sepsis and during antibiotics treatment. Methods The biomarkers evaluated were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total and PCT (Procalcitonin). Plasma was obtained at admission to ICU and during follow-up at days 2 and 3. Antibiotic treatment was started or reviewed on admission to ICU. The results were compared to SOFA and KDIGO-scores and to survival. 277 patients admitted to ICU were included of which 30% had sepsis. The other groups were categorized as miscellaneous, other medical and trauma. Results The plasma concentrations of all four biomarkers were highly elevated with the highest concentrations in sepsis patients. During the follow-up period HNL Dimer decreased already day 2 and further so day 3 (p < 0.00001) in contrast to unchanged concentrations of the other three biomarkers. HNL Total showed the strongest relationships to the clinical scores (p < 0.0001) and was by multiples regression analysis independently related to these scores. Conclusion The neutrophil specific biomarker HNL Dimer seems to be a superior means to monitor the response to antibiotic treatment in ICU patients and confirms earlier findings of a rapid decline after adequate antibiotic treatment in sepsis. HNL Total reflects epithelial cell activity in the body and is an interesting biomarker for the management of organ failure in such patients.
Synergism between Tocotrienol and i-PRF in HFSCs proliferation: an in-vitro study
Authors: Contractor Murtaza Mohemadali , Bhate Kalyani , Kheur Supriya , Kharat Avinash , Samuel Sherwin , U Manoj Kumar 
Published: July 2023

Abstract
Introduction: Androgenic Alopecia (AGA) is an early onset of hair loss found in both males and females. With an increase in stress and hormonal imbalances, the need for a better and faster alternative to today’s medicine for alopecia is increasing. Adding an adjunct like Aloe Vera to the gold standard platelet concentrate in the treatment of alopecia may boost hair growth. To find an optimum concentration and evaluate the synergism between Aloe Vera and injectable platelet-rich fibrin (i-PRF) is the aim of this in-vitro study.
Materials & Method: Hair follicles from an individual suffering from AGA were prepared and stored in an incubator. Stem cell characterization was done and stem cells were multiplied. Hair follicle-derived stem cells (HFSCs) were subjected to different concentrations of Aloe Vera, i-PRF, and i-PRF with Aloe Vera in different Petri dishes.
Result: Aloe Vera group shows an increase in HFSCs proliferation up to a certain concentration, after that it shows cell senescence. I-PRF on other hand shows a direct relation between concentration and cell proliferation. The combination group at a particular concentration shows double the cell proliferation than the rest of all.
Conclusion: Alopecia and its treatment are in a wide range and have evolved with time. No single treatment modality can be sufficient to treat a disease at its best. Adjunct therapy when incorporated into the standard treatment results in faster and better hair growth. Also, the optimization of the concentration of any product is of great value.
Electric Field Tuning of a Nickel Zinc Ferrite Resonator by Non-Linear Magnetoelectric Effects
Authors: Popov Maksym , Machi Alexander , Inman Jerad , Bidthanapally Rao , Saha Sujoy , Qu Hongwei , Jain Menka , Page Michael R. , Sriniva Gopalan 
Published: July 2023

Abstract
The nature of nonlinear magnetoelectric (NLME) effect has been investigated at room-temperature in single-crystal Zn substituted nickel ferrite. Tuning of the frequency of magnetostatic surface wave (MSSW) modes under an applied pulsed DC electric field/current has been utilized to probe the effect. The frequencies of the MSSW modes at 8–20 GHz were found to down shift by 400 MHz for an applied DC power P of 100 mW and the frequency shift was the same for all of the MSSW modes and linearly proportional to P. A model is proposed for the effect and the NLME phenomenon was interpreted in terms of a reduction in the saturation magnetization due to the DC current. The estimated decrease of magnetization with applied electric power, estimated from data on mode frequency versus P, was − 2.50 G/mW. The frequency tuning efficiency of the MSSW modes due to NLME effects in the ferrite resonator was found to be 4.1 MHz/mW which is an order of magnitude higher than the shift reported for M-type strontium and barium hexaferrite resonators investigated earlier and has the potential for miniature, electric field tunable, planar microwave devices for the 8–20 GHz frequency range.
Well-managed urbanization could halve nitrogen pollution in China
Authors: Gu Baojing , Deng Ouping , Wang Sitong , Ran Jiangyou , Huang Shuai , Zhang Xiuming , Duan Jiakun , Zhang Lin , Xia Yongqiu , Reis Stefan , Xu Jiayu , Xu Jianming , de Vries Wim , Sutton Mark 
Published: July 2023

Abstract
Halving nitrogen pollution is crucial for achieving sustainable development goals (SDGs). However, how to reduce nitrogen pollution from multiple sources remains a grand challenge. Here we show that reactive nitrogen (Nr) pollution could be roughly halved by well-managed urbanization in China by 2050, with emissions of NH3, NOx and N2O to air declining by 44%, 30% and 33%, respectively, and Nr to water bodies by 53%. Urbanization shifts population from rural to urban areas and promotes large-scale and crop-livestock coupled farming, which reduces non-point source pollution from rural sewage and agriculture. Although rural-to-urban migration increases point-source nitrogen emissions in metropolitan areas, regional air and water quality can be improved by reducing upstream and regional total Nr losses, with increased opportunities to control of point source emissions vs. diffuse emissions. Approximate US$ 61 billion would be required for additional urban waste treatment, agricultural land consolidation and livestock relocation, as well as upgrading industrial facilities. However, the overall benefits are calculated at US$ 245 billion due to increases in agricultural productivity and improvements in environmental quality. Such a large benefit-to-cost ratio suggests the feasibility and cost-effectiveness of halving Nr pollution through urbanization, and this would make significant contributions to achieving several SDG targets.