bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psoriasis‐like skin rash triggered by a local infection in a patient with eosinophilic granulomatosis with polyangiitis that was well controlled by mepolizumab treatment
Authors: Yokota Naho , Kondo Makoto , Hayashi Akinobu , Ichishi Masako , Matsushima Yoshiaki , Nakanishi Takehisa , Habe Koji , Yamanaka Keiichi 
Published: June 2023

Key Clinical messageA patient with eosinophilic granulomatosis with polyangiitis, who was well‐controlled by pharmacotherapy, developed a psoriasis‐like rash due to a local infection. It represents the consequence of an immunologic imbalance.AbstractA 48‐year‐old woman was diagnosed with eosinophilic granulomatosis with polyangiitis and treated with mepolizumab. While on treatment, she developed a psoriasis‐like rash on her lower legs following a local ear infection. The rash promptly disappeared after the ear infection cleared and did not recur. The psoriasis‐like rash that appeared was pathologically similar to psoriasis. Excessive production of inflammatory cytokines by the immune system is believed to be involved in the pathogenesis of psoriasis vulgaris. These cytokines are known to induce inflammatory responses and promote epidermal cell proliferation. It is possible that mepolizumab treatment suppressed Th2‐type cytokines, while the local ear infection temporarily induced a strong Th1‐type immunity. This immunologic imbalance may have led to the development of a psoriasis‐like rash.
Light‐Promoted Basic Nitrogen Unmasking in Arene Ruthenium Complexes Derived from Z‐Configured 2,2′‐Azobispyridine
Authors: Long Jonathan , Rocard Lou , Van Elslande Elsa , Retailleau Pascal , Xie Juan , Bogliotti Nicolas 
Published: June 2023

AbstractTwo novel 2,2′‐azobispyridine derivatives bearing N‐dialkylamino substituents at position 4,4′ were synthesized and their E–Z photoswitching behavior was characterized by combination of 1H‐ and 13C NMR spectroscopy, UV–Vis absorption and DFT calculations. Both isomers act as ligands towards arene‐RuII centers, leading either to E‐configured 5‐membered chelates (involving coordination of nitrogen atoms from N=N bond and pyridine) or to the uncommon Z‐configured 7‐membered chelates (involving coordination of nitrogen atoms from both pyridines). The latter show good stability in the dark, allowing single crystal X‐ray diffraction study to be reported here for the first time. All synthesized Z‐configured arene‐RuII complexes undergo irreversible photo‐isomerization to their corresponding E isomers with rearrangement of their coordination pattern. This property was advantageously exploited for the light‐promoted unmasking of a basic nitrogen atom of the ligand.
External Flash Generation of Carbenoids Enables Monodeuteration of Dihalomethanes
Authors: Okamoto Kazuhiro , Higuma Ryosuke , Muta Kensuke , Fukumoto Keita , Tsuchihashi Yuta , Ashikari Yosuke , Nagaki Aiichiro 
Published: June 2023

AbstractIn this study, incorporation of one deuterium atom was achieved by H−D exchange of one of the two identical methylene protons in various dihalomethanes (halogen=Cl, Br, and I) through a rapid‐mixing microflow reaction of lithium diisopropylamide as a strong base and deuterated methanol as a deuteration reagent. Generation of highly unstable carbenoid intermediate and suppression of its decomposition were successfully controlled under high flow‐rate conditions. Monofunctionalization of diiodomethane afforded various building blocks composed of boryl, stannyl, and silyl groups. The monodeuterated diiodomethane, which served as a deuterated C1 source, was subsequently subjected to diverted functionalization methods to afford various products including biologically important molecules bearing isotope labelling at specific positions and homologation products with monodeuteration.
Artemiprincepsolides A—F, Novel Germacrane‐guaiane and Eudesmane‐guaiane Sesquiterpenoid Dimers from Artemisia princeps and Their Antihepatoma Activity
Authors: Su Li‐Hua , Ma Wen‐Jing , Ma Yun‐Bao , Li Tian‐Ze , Geng Chang‐An , Dong Wei , He Xiao‐Feng , Zhang Xue‐Mei , Chen Ji‐Jun 
Published: June 2023

Comprehensive SummaryArtemiprincepsolides A—F (1—6) were isolated from Artemisia princeps guided by bioactivity and elucidated by comprehensive spectral data and ECD calculation. Compounds 1—3 represented the first connecting model of germacrane‐guaiane hetero‐dimeric adducts, and compounds 4—6 were eudesmane‐guaiane hetero‐coupled sesquiterpenoid dimers, meanwhile, all these were presumably formed by Diels‐Alder cycloaddition. Compounds 1—6 were evaluated for their hepatomatic cytotoxicity on three hepatoma cell lines, and demonstrated cytotoxicity with IC50 values in the range of 5.0—67.3 μmol/L. Interestingly, compound 1 manifested significant cytotoxicity against HepG2, Huh7, and SK‐Hep‐1 cells with IC50 values of 9.9, 9.2, and 5.0 μmol/L, which were almost equivalent to the positive control, sorafenib. Flow cytometry data and Western blot assays revealed the most active compound 1 dose‐dependently inhibited cell migration and invasion, and significantly induced HepG2 cells arrest in G2/M phase by downregulating proteins pcdc2 and upregulating the level of protein CyclinB1; and induced apoptosis by downregulating of Bcl‐2 expression and upregulating Bax level.
Traditional and modern pigments in Gino Severini's Swiss murals
Authors: Moretti Patrizia , Zumbühl Stefan , Scherrer Nadim , Piqué Francesca 
Published: June 2023

AbstractBetween 1924 and 1947, Gino Severini decorated five churches in the Romand region of Switzerland with monumental religious wall paintings. This mural art played an important role in the Italian artist's career despite being mostly unknown and not easily found. The painting methods and materials of these modern Swiss murals were characterized by combining historical and archival research with onsite visual and scientific examination. Most pigments were identified with noninvasive methods integrating mapping techniques (i.e., technical photography and digital microscopy) with point analysis (x‐ray fluorescence and reflection FT‐IR spectroscopy). The results of these portable techniques were completed with SEM‐EDS, μFT‐IR FPA imaging, and μRaman analyses on micro‐samples which provided stratigraphic and compositional information to complement the noninvasive results. Overall, the data obtained show that Severini used both traditional pigments (e.g., Sangiovanni white and ochres/earths of various color) and modern ones, such as cadmium‐based pigments, with different painting techniques (e.g., zinc white was applied exclusively a secco). Apart from cerulean blue (cobalt stannate) and Naples yellow (lead antimonate) found only in two locations, the same set of pigments was documented in all of Severini's Swiss murals. The characterization of the artist's palette is important to understand the technical painting process followed by Severini, his interest on new painting materials available on the market and, at the same time, loyalty towards traditional painting methods, such as painting a fresco.
Phenotypic and genotypic resources for the USDA quinoa (Chenopodium quinoa) genebank accessions
Authors: Nepal Nirman , Condori‐Apfata Jorge Alberto , Gaire Rupesh , Anco Mayela Elizabeth Mayta , Scofield Steven , Zhang Cankui , Mohammadi Mohsen 
Published: June 2023

AbstractQuinoa (Chenopodium quinoa) is a nutritious grain, with balanced composition of amino acids, and a facultative halophyte. Under greenhouse conditions, we assessed 148 quinoa accessions from the USDA genebank for grain weight, phenological, and morphological characteristics. For all traits, the analysis of variance revealed a significant difference among accessions. The accessions matured as late as 146 days after planting and produced grain weight up to 19.6 g/plant. Days to maturity showed negative correlation with grain weight per plant, whereas the number of branches was positively correlated with grain weight per plant. By adopting the NsiI/BfaI combination to enhance the genotyping‐by‐sequencing technique, we were able to generate 59,248 filtered single nucleotide polymorphism markers by mapping to the reference genome. Molecular markers showed an average heterozygosity of 11.76% across the accessions with a range of 4.9%–21.9%. The first two principal component analyses (PCAs) explained nearly 50% of molecular markers. The genetic diversity analysis using PCA revealed the presence of four main groups. Groups A and B consisted of mainly Bolivian and Peruvian accessions with relatively slower maturity and taller plant stature. In contrast, groups C and D were mainly accessions registered from USA and Chile with relatively faster maturity and shorter plant stature. Groups C and D together have shown far more private single nucleotide polymorphisms than accessions in A and B groups, indicating the higher levels of diversity within these groups and more levels of similarities among individuals of A and B groups. Marker‐trait association revealed significant markers for grain weight per plant and days to flowering. We only analyzed linkage disequilibrium on the scaffolds that harbor these marker‐trait associations. LD expressed in r2 persisted as high as 0.2 in ranges greater than 600 kb for scaffold 1992 but dropped more quickly for scaffold 1843. These phenotypic and genotypic resources will serve as a reference for the cataloging and conservation of germplasm and, for the selection of a core collection for the improvement of quinoa to address food security.
Utility of a partially covered metal stent for salvage sealing therapy for bleeding caused by duodenal invasion of pancreatobiliary cancers: Case series
Authors: Yamashita Yasunobu , Yamazaki Hirofumi , Kawaji Yuki , Tamura Takashi , Hatamaru Keiichi , Itonaga Masahiro , Ashida Reiko , Kitano Masayuki 
Published: June 2023

AbstractPancreatobiliary cancer‐related gastrointestinal bleeding caused by duodenal invasion can be a life‐threatening condition that is hard to control. It is unclear whether a covered self‐expandable metal stent (CSEMS) is useful for hemostasis of bleeding related to advanced pancreatobiliary cancer. The aim of this study was to evaluate the utility of a CSEMS for hemostasis of bleeding caused by duodenal invasion of pancreatobiliary cancer. Between January 2020 and January 2022, seven patients in whom a duodenal CSEMS was inserted to control pancreatobiliary cancer‐related bleeding were enrolled. The technical and clinical success rates with respect to hemostasis, procedure time, and adverse events were assessed. All patients were inoperable cases (six with pancreatic cancer [five, stage IV; one, stage III]; and one with gallbladder cancer [stage IV]) in whom CSEMs were inserted to treat refractory bleeding caused by cancer invasion. Hemostasis was achieved in all cases (100% [7/7]). The mean procedure time was 17 ± 7.9 min. There were no adverse events, including migration and rebleeding. No rebleeding occurred up until the time of death in any of the cases (mean follow‐up period, 73 ± 27 days). Deployment of duodenal CSEMS is a useful salvage therapy for bleeding caused by advanced pancreatobiliary cancer invasion.
Phylogeographic analysis of Siraitia grosvenorii in subtropical China provides insights into the origin of cultivated monk fruit and conservation of genetic resources
Authors: Xie Bingbin , Lai Bowen , Chen Liping , Wei Sujuan , Tang Shaoqing 
Published: June 2023

AbstractSiraitia grosvenorii, an economically important plant species with high medicinal value, is endemic to subtropical China. To determine the population structure and origin of cultivated S. grosvenorii, we examined the variation in three chloroplast DNA regions (trnR‐atpA, trnH‐psbA, trnL‐trnF) and two orthologous nuclear genes (CHS and EDL2) of S. grosvenorii in 130 wild individuals (selected from 13 wild populations across its natural distribution range) and 21 cultivated individuals using a phylogeographic approach. The results showed three distinct chloroplast lineages, which were restricted to different mountain ranges, and strong plastid phylogeographic structure. Our findings suggest that S. grosvenorii likely experienced ancient range expansion and survived in multiple refuges in subtropical China during glacial periods, resulting in population fragmentation in different mountainous areas. Our results also demonstrated that wild populations in Guilin (Guangxi, China) share the same gene pool as cultivated S. grosvenorii, suggesting that current cultivars were collected directly from local wild resources, consistent with the principles of “nearby domestication.” The results of this study provide insights into improving the efficiency of S. grosvenorii breeding using a genetic approach and outline measures for the conservation of its genetic resources.
What theF‐POD? Comparing theF‐PODandC‐PODfor monitoring of harbor porpoise (Phocoena phocoena)
Authors: Todd Nicole Rose Eileen , Kavanagh Ailbhe Sarah , Rogan Emer , Jessopp Mark John 
Published: June 2023

AbstractPassive acoustic monitoring (PAM) is a cost‐effective method for monitoring cetacean populations compared with techniques such as aerial and ship‐based surveys. The Cetacean POrpoise Detector (C‐POD) has become an integral tool in monitoring programs globally for over a decade, providing standardized metrics of occurrence that can be compared across time and space. However, the phasing out of C‐PODs following the development of the new Full waveform capture POD (F‐POD) with increased sensitivity, improved train detection, and reduced false‐positive rates represents an important methodological change in data collection, particularly when being introduced into existing monitoring programs. Here, we compare the performance of the C‐POD with that of its successor, the F‐POD, co‐deployed in a field setting for 15 months, to monitor harbor porpoise (Phocoena phocoena). While similar temporal trends in detections were found for both devices, the C‐POD detected only 58% of the detection‐positive minutes (DPM), recorded by the F‐POD. Differences in detection rates were not consistent through time making it difficult to apply a correction factor or directly compare results obtained from the two PODs. Generalized additive models (GAMs) were used to test whether these differences in detection rates would have an effect on analyses of temporal patterns and environmental drivers of occurrence. No differences were found in seasonal patterns or the environmental correlates of porpoise occurrence (month, diel period, temperature, environmental noise, and tide). However, the C‐POD failed to detect sufficient foraging rates to identify temporal patterns in foraging behavior, which were shown by the F‐POD. Our results suggest that the switch to F‐PODs will have little effect on determining broad‐scale seasonal patterns of occurrence but may improve our understanding of fine‐scale behaviors such as foraging. We highlight how care must be taken interpreting F‐POD results as indicative of increased occurrence when used in time‐series analysis.
Complete mitochondrial genomes of two moths in the tribe Trichaeini (Lepidoptera: Crambidae) and their phylogenetic implications
Authors: Tang Ci , Du Xicui 
Published: June 2023

AbstractThe complete mitochondrial genomes of two Prophantis species in the tribe Trichaeini (Lepidoptera: Crambidae) were sequenced using high‐throughput sequencing technology. They were assembled and annotated: The complete mitogenomes of P. octoguttalis and P. adusta were 15,197 and 15,714 bp, respectively, and contain 13 protein‐coding genes (PCGs), 22 transfer RNA genes, two ribosomal RNA genes, and an A + T‐rich region. Their arrangement was consistent with the first sequenced mitogenome of Bombyx mori (Bombycidae) in Lepidoptera, which had the trnM–trnI–trnQ rearrangement. The nucleotide composition was obviously AT‐biased, and all PCGs, except for the cox1 gene (CGA), used ATN as the start codon. Except for trnS1, which lacked the DHU stem, all tRNA genes could fold into the clover‐leaf structure. The features of these two mitogenomes were highly consistent with those of other species of Spilomelinae in previous studies. Phylogenetic trees of Crambidae were reconstructed based on mitogenomic data using maximum likelihood and Bayesian inference analysis methods. Results showed that Trichaeini in this study robustly constitute a monophyletic group in Spilomelinae, with the relationships (Trichaeini + Nomophilini) + ((Spilomelini + (Hymeniini + Agroterini)) + Margaroniini). However, the affinities of the six subfamilies Acentropinae, Crambinae, Glaphyriinae, Odontiinae, Schoenobiinae, and Scopariinae within the “non‐PS Clade” in Crambidae remained doubtful with unstable topologies or low supports.
Contingent partitioning and adaptation in hydrological systems
Authors: Phillips Jonathan D. 
Published: June 2023

AbstractThe question of whether the concept of adaptation can be applied to Earth surface systems (independently of biological adaptation) is addressed by examining hydrological flow systems. Hydrological systems are represented in terms of a partitioning of water inputs among various flux and storage components and outflows or outputs of the system. Partitioning is contingent on the flow system in question and the synoptic situation (i.e., drier, low‐input vs. wetter, high‐input conditions). The general allocation among inputs, flows through or within the system, storage and outputs is examined via analysis of 20 scenarios for soil hydrology, a fluvial channel‐wetland complex and a fluviokarst landscape representing different combinations of positive, negative and zero (neutral) relationships among these elements, and positive self‐reinforcing and negative self‐limiting effects. Conditions for stability were determined using the Routh–Hurwitz criteria and linked to the two fundamental roles or ‘jobs’ of hydrological flow systems. The ecological job is to support biota and biogeochemical fluxes and transformations necessary for ecosystem functions. The geophysical job is to remove excess water. Results show that low‐input scenarios for the soil, fluvial wetland and fluviokarst scenarios are marked by dynamical instability. During drier periods the geophysical job is irrelevant and the ecological functions are suboptimal. Instability allows for rapid state changes when moisture inputs increase, to system states that support ecosystem functions. High‐input, excess moisture and flood scenarios, by contrast, are generally dynamically stable. In wetter conditions, the ecological functions are not moisture‐stressed, and the geophysical job becomes paramount. The high‐input stability is associated with activation of ‘spillway’ mechanisms that allow the systems to maintain themselves by efficient export and augmented storage of excess water. Contingent partitioning indeed appears to be an adaptation mechanism in hydrological systems and suggests the possibility of adaptation in other Earth surface systems with important abiotic components.
A novel method applicable to large‐scale active magnetic shielding system which effectively compensates gradient magnetic fields originated from the surrounding buildings
Authors: Ogata Takuto , Murata Naofumi , Shimizu Takafumi 
Published: June 2023

AbstractWe propose the novel magnetic compensation method which is suitable to compensate gradient magnetic fields. The method is to be applied to a conventional large‐scale, tri‐axial active magnetic shielding system such as a spacecraft magnetic testing facility. The essences of this method are the adoption of compensation coils which have degrees of freedom in their coil orientations, and their installation position, which is chosen to have certain distances from the center of the shielding area. The method works with at least four compensation coils. In this research, we actually demonstrated the method with a scaled‐down experiment. Disturbance magnetic field (B) at the target zone was suppressed from 21.33 nT to −1.54 nT and magnetic field uniformity (ΔB) within the test zone was improved from 2.3 nT to 0.015 nT. In terms of magnetic field gradient, improvement from over 4 nT/m to below 0.5 nT/m was achieved.
Development of capacitive‐coupled hall‐type MHD generator
Authors: Kato Gaigo , Takahashi Kazumasa , Kikuchi Takashi , Sasaki Toru 
Published: June 2023

AbstractWe have demonstrated a capacitively coupled Hall‐type MHD generator using ECR plasma. To clarify the characteristics of the fabricated MHD generator, we measured the power generation characteristics as a function of magnetic field strength using a DC Hall‐type MHD power generation experiment. The results showed that the output power decreased due to magnetic pressure at the higher magnetic field. However, the output power corresponded to the theoretical value at the lower magnetic field. An AC Hall‐type MHD power generation experiment was conducted using an AC magnetic field. As a result, full‐wave rectification voltage was observed as per theory. Finally, capacitively coupled Hall‐type MHD power generation experiments were conducted, and full‐wave rectified waveforms were observed as in AC Hall‐type MHD power generation. These waveforms were similar to the output waveforms predicted from theory. These results show that the capacitively coupled Hall‐type MHD generator is feasible.
Impact of sleep apnoea on 30 day hospital readmission rate and cost in heart failure with reduced ejection fraction
Authors: Mathew Don , Kosuru Bhanu , Agarwal Siddharth , Shrestha Utsav , Sherif Akil 
Published: June 2023

AbstractAimsIn this study, we estimated the 30 day all‐cause and heart failure‐specific readmission rates, predictors, mortality, and hospitalization costs in patients with obstructive sleep apnoea admitted with acute decompensated heart failure with reduced ejection fraction.Methods and resultsThis is a retrospective cohort study using the Agency of Healthcare Research and Quality's National Readmission Database for the year 2019. The primary outcome was the 30 day all‐cause hospital readmission rate. The secondary outcomes were (i) in‐hospital mortality rate for index admissions; (ii) 30 day mortality rate for index hospitalizations; (iii) the five most common principal diagnosis for readmission; (iv) readmission in‐hospital mortality rate; (v) length of hospital stay; (vi) independent risk factors for readmission; and (vii) hospitalization costs. We identified 6908 hospitalizations that met our study definition. The mean patient age was 62.8 years, and women comprised only 27.6% of patients. The 30 day all‐cause readmission rate was 23.4%. 48.9% of readmissions were due to decompensated heart failure. The in‐hospital mortality rate during readmissions was significantly higher than that of the index admission (5.6% vs. 2.4%; P < 0.05). The mean length of stay for patients during index admissions was 6.5 days (6.06–7.02), while during readmissions, it was 8.5 days (7.4–9.6; P < 0.05). The mean total hospitalization charges at index admissions were $78 438 (68 053–88 824), while during readmissions, they were higher at $124 282 (90 906–157 659; P < 0.05). The mean total cost of hospitalization during index admissions was $20 535 (18 311–22 758), while at readmissions, it was higher at $29 954 (24 041–35 867; P < 0.05). The total hospital charges for all 30 day readmissions were $195 million, and total hospital costs was $46.9 million. The variables found to be associated with increased rate of readmissions were patients with Medicaid insurance, higher Charlson co‐morbidity Index, and longer length of stay. The variables associated with lower rate of readmissions were prior percutaneous coronary intervention and patients with private insurance.ConclusionsIn patients with obstructive sleep apnoea admitted with heart failure with reduced ejection fraction, we found a substantial all‐cause readmission rate of 23.4% with heart failure readmission constituting about 48.9% of readmissions. Readmissions were associated with higher mortality and resource use.