bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Aloe Vera On Mmp-1 And Timp-1 Expression on Diabetic Wound Healing
Authors: SEYREK Rohlat , SOKER Sevda , KAPLAN Özge , ÖZDEMİR BAŞARAN Süreyya , AŞIR Fırat , DEVECİ Engin , ŞEKER Uğur 
Published: September 2023

Aim: The aim of this study is to investigate the healing aspect of aloe vera in diabetes mellitus, which inhibits wound healing.
Methods: Diabetes model was created with streptozotocin. At the end of the 14-day experiment, blood glucose was measured from the tail vein of animals in all groups and blood was taken from the heart and sacrificed. Histopathology and immunohistochemical statistics and evaluation were performed.
Results: Pycnosis and degeneration of epithelial cells were observed in diabetes groups. Leukocyte infiltration in the dermal papilla, degeneration of collagen fibers and an increase in the extracellular matrix were observed. It was observed that the epithelial layer in the aloe vera group was histologically close to the control group. It was observed that decreased inflammation in the dermal papilla and decreased in organized collagen fibers and vessel dilatation were observed. In the control group, MMP-1 and TIMP-1 expression were positive in the epidermis and dermis layers. In the diabetes group, weak expression of MMP-1 and TIMP-1 was observed in cells in the epidermis and dermis. The expression of MMP-1 and TIMP-1 in the surface epithelium in the aloe vera group was increased compared to the diabetes group.
Conclusions: Aloe vera accelerated cell and extracellular matrix regeneration with its anti-oxidative activity
Comparison of Excisional Stapler Hemorrhoidopexy Method and Non-Excisional Arterial Detection Ligation Method; One Year Follow-Up
Authors: SAKOĞLU Nevin , OCAKOĞLU Aziz 
Published: September 2023

Abstract
Aim: Hemorrhoidal disease is a chronic disease of the lower rectum and anus occurs due to increased pressure during straining. Millions of people in the world suffer from this disease. Since the stage of the disease and the symptoms of the patients do not show parallelism, we evaluated the results of two different surgical methods; arterial detection ligation (ADL) and stapler hemorrhoidopexy (SH).
Methods: A retrospective study among patients who were operated for hemorrhoids between 2021-2022.
Results: Adult patients with Grades II, III and IV were included. SH and ADL groups containing 60 patients were formed. Pain complaints (VAS) and normal daily activities (KATZ) of patients after surgery were examined. In this study, statistical analyzes were performed with NCSS (Number Cruncher Statistical System) 2007 Statistical Software (Utah, USA) package program. 50 of the patients were female and 70 were male. There was no difference between the age and gender distributions of the SH and ADL groups (p=0.231, p=0.711). On the 1st day VAS values in the SH group were found to be statistically significantly higher than the ADL group (p=0.003). When the daily activities of both groups were examined, the dressing (p=0.042) and toileting (p=0.012) activities in the SH group were lower. On the other hand, there was a statistically significant difference within the groups (SH; p= 0,0001, ADL; p=0,0001) related to the pain assessments.
Conclusions: When both methods were examined, the success rate of two techniques was similar and ADL least affects the anatomy of the anorectal region without serious complication risk.
The Effect Of Advancing Age On The Temporomandibular Joint Osteoarthritis Findings
Authors: SOYDAN ÇABUK Damla , DUYAN YÜKSEL Hazal 
Published: September 2023

Aim: The aim of this study is to evaluate temporomandibular joint osteoarthritis (TMJ OA) findings in elder patients with cone beam computed tomography.
Materials and methods: One hundred and sixty-seven patients (136 women, 31 men) participated in the study. Three hundred and thirty-four joints were evaluated in the study. According to the presence of OA, TMJs were divided into two groups as “with osteoarthritis” and “without osteoarthritis”. When any of the osteoarthritis findings were present, the joint was included in the “with osteoarthritis” group. OA findings were listed as osteophyte, erosion, flattening, sclerosis and pseudocyst. Also, TMJs were divided into two age groups: Group 1 (50-64 years old) and group 2(65-81 years old) For statistical analysis, SPSS v20 were used.
Results: There was no significant difference between genders for the presence of OA (p>0.005). There were significant differences between group 1 and group 2 for erosion, flattening and sclerosis (p0.005).
Conclusion: Radiological findings like erosion, flattening and sclerosis can be seen more common with advancing age.
Is There A Structural Basis For Vasovagal Syncope? Cardiac Functions In Patients With Vasovagal Syncope
Authors: ALPASLAN Erkan , TAŞ Ümmü , TAŞ Sedat , OZPELIT Ebru 
Published: September 2023

Aim: The pathophysiology of vasovagal syncope (VVS) is not completely understood. Some echocardiographic parameters have been defined to contribute to its pathophysiology. However. whether right atrial (RA) and right ventricular (RV) functions have any impact on development of VVS is not well known. In this study we aimed to evaluate the baseline echocardiographic parameters in patients with VVS with special focus on right ventricle and atrium functions.
Material and methods: We evaluated the medical records of 42 patients with VVS and 41 age and sex matched healthy subjects. Patients with at least two syncopal attack and positive head-up-tilt test were enrolled in the study. All medical records of echocardiography and head-up-tilt test were obtained.
Results: Among left ventricular function parameters, there were no significant difference between the groups. Right ventricle myocardial performance index (p= 0.003) and maximal pulmoner systolic flow velocity (PVmax) (p=0.03) were significantly differ between the groups. RAA was significantly larger (p=0.04) and the ratio of tricuspid filling velocities (E/A), (p=0.01) was significantly lower in VVS group.
Conclusions: The findings of the present study indicate a subtle right atrial diastolic dysfunction in patients with VVS. Decreased right atrial contribution to RV filling may cause a lower RV stroke volüme which explains the lower PVmax values in our VVS group. All together, those findings may serve for a tendency to low output states and hypotension as in VVS.
Evaluation of the correlation between thalamic area and cognitive functions in patients with early-stage relapsing-remitting multiple sclerosis
Authors: AYAS Selahattin , CANBAZ KABAY Sibel 
Published: September 2023

Background: The aim of this study is to investigate the presence of cognitive dysfunction and deep gray matter involvement in the early-stages of Relapsing-Remitting Multiple Sclerosis(RRMS) disease and examine the relationship between them.
Materials and Methods: Thirty-four patients and 23 healthy individuals were included in the study. Patients diagnosed with RRMS according to the Revised 2010 and 2017 McDonald criteria, aged between 18-50, were enrolled in the study. The control group consisted of 23 healthy individuals with normal neurological examination, cranial magnetic resonance imaging(MRI), and cognitive functions. All participants underwent a neuropsychological test battery that covers memory, executive functions, language, and visuospatial domains, and the results of these tests were compared among the study groups. The data on MRI parameters, including the areas of the thalamus and corpus callosum as well as the width of the third ventricle, were compared among the study groups. Finally, the relationship between neuropsychological test results and MRI parameters was investigated in patients with early-stage RRMS.
Results: The mean duration of the disease for MS patients was 3.53 years, and their median EDSS score was 2. It was observed that memory, executive functions, and fine motor skills were affected in early-stage RRMS patients. This impairment correlated with a decrease in the thalamus and corpus callosum areas and an increase in the third ventricle width.
Conclusion: The MRI parameters defined as biomarkers for potential cognitive impairments in RRMS have critical importance in predicting the prognosis of the disease and taking early measures against future cognitive dysfunction.
PENGARUH FIRM SIZE DAN GROWTH OPPORTUNITY TERHADAP FIRM VALUE MELALUI CASH HOLDING SEBAGAI VARIABEL INTERVENING PADA PERUSAHAAN MAKANAN DAN MINUMAN YANG TERDAFTAR DI BEI TAHUN 2018-2021
Authors: Maulida Yuni Astri Ayu , Sari Lita Permata , Pramitasari Triska Dewi 
Published: September 2023

Technological developments The change in business world and the revolution of entrepreneurship have changed because of technological development. Companies now focus not only on profit, but also on appreciation. Technology has facilitated the transformation of small businesses into global businesses. This study aims at is analyzing and testing the effects of Firm size and Growth opportunity on Firm value through Cash holding as an intervening variable in food and beverage companies listed in the Indonesia Stock Exchange year 2018-2021. The population in this study were 21 food and beverages companies listed on the Indonesian Stock Exchange during the 2018 – 2021 period. The sampling technique was determined by purposive sampling. Data analysis and hypothesis testing in this study use Structural Equation – Partial Least Square (PLS-SEM). The results of the direct effect hypothesis test using the Smart PLS 3.0 application shows that Firm size has a negative significant effect on Cash holding, Growth opportunity has a positive but not significant effect on Cash holding, Firm size has a negative but not significant effect on Firm value, Growth opportunity has a negative but not significant effect on Firm value and Cash holding have a negative but not significant effect on the Firm value. Meanwhile, the results of the indirect effect hypothesis test show the firm size variable has a positive but not significant effect on Firm value through Cash holding and Growth opportunity have a negative but not significant effect on Firm value through Cash holding.
PENGARUH BUDAYA ORGANISASI, MOTIVASI KERJA DAN GAYA KEPEMIMPINAN TRANSFORMASI TERHADAP KEPUASAN KERJA ASN SERTA KINERJA ASN DI DINAS PETERNAKAN DAN PERIKANAN KABUAPTEN SITUBONDO
Authors: Nofiantari Efi , Karnadi Karnadi , Pramesthi Riska Ayu 
Published: September 2023

Human resources are one of the important factors in a company to achieve its goals and objectives, because human resources are one of the determining factors for the success or failure of a company in achieving its goals. One that must be considered in managing human resources is regarding the placement of employees. The aim of this study was to determine the effect of organizational culture, work motivation and transformational leadership style on ASN job satisfaction and ASN performance in the Livestock and Fisheries Service of Situbondo District. the population in this study were all ASN employees of the Situbondo District Livestock and Fisheries Service. Random sampling method (simple probability sampling) without regard to strata in the population in this study. In taking this sample using saturated sampling, namely the technique of determining the sample when all members of the population are sampled. Data analysis and hypothesis testing in this study used the Structural-partial Least square equation model (PLS-SEM).
The results of the hypothesis test have a direct effect using the smart PLS 3.0 application, indicating that organizational culture has a significant positive effect on job satisfaction. Work motivation has a significant positive effect on job satisfaction. Transformational leadership style has a significant positive effect on job satisfaction. Organizational culture has a significant positive effect on performance. Work motivation has a significant positive effect on performance. Transformational leadership style has no significant positive effect on performance. Job satisfaction has a significant positive effect on performance. Organizational culture on performance through job satisfaction has no significant positive effect. Work motivation on performance through job satisfaction has a significant positive effect. Transformational leadership style on performance through job satisfaction has a significant positive effect.
PENINGKATAN MOTIVASI DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI MELALUI KEPUASAN KERJA PEGAWAI PADA KELURAHAN ARDIREJO DAN KELURAHAN MIMBAAN KECAMATAN PANJI KABUPATEN SITUBONDO
Authors: Andriawan Dio Bagus , Karnadi Karnadi , Minullah Minullah 
Published: September 2023

Human resources are individuals capable of and willing to assist an organization in achieving its goals. The purpose of this research is to determine the improvement of motivation, work discipline, and job satisfaction, as well as the performance of human resources in Ardirejo Village and Mimbaan Village of Panji Sub-District. The population in this study consists of all employees of Ardirejo Village and Mimbaan Village in Panji Sub-District, totaling 38 employees, both civil servants (ASN) and non-civil servants. The sampling technique is determined by purposive sampling. The data analysis and hypothesis testing of this research employed Partial Least Square-Structural Equation Modeling (PLS-SEM).
The results of hypothesis testing for direct effects using Smart PLS 3.0 application indicate that motivation has a significant positive influence on job satisfaction. Work discipline has a negative influence on job satisfaction, but it is not significant. Motivation has a significant positive influence on performance. Work discipline has a negative influence on performance, but it is not significant. Job satisfaction has a negative influence on performance, but it is not significant. The results of hypothesis testing for indirect effects show that motivation does not significantly affect performance through job satisfaction. Work discipline does not significantly affect performance through job satisfaction.
Mapping of Empirical Studies on Research Integrity in University Institutions
Authors: Carcausto-Calla Wilfredo , Zapata Noel Alcas , Cueva Francis Esmeralda Ibarguen , Morales Santiago Aquiles Gallarday , Rios Alejandro Ramirez 
Published: September 2023

The purpose of the study was to systematically map the available knowledge on the characteristics of the primary studies of integrity in research (RI) in universities. A systematic mapping of empirical studies indexed Scopus and Web of Science databases over the past ten years. Among the findings is the growing trend of producing original articles on IR, although it remains low compared to other types of document found in the initial search. There is also in exploring perspectives and attitudes integrity violations and the ways to prevent them. This study serves as a reference to other researchers wish to study with mixed methods or integrate approaches ethical approaches in order to better understand and develop new ways of promoting and educating academics, researchers and stakeholders in the university environment worldwide in relation to ethics and research integrity.

Received: 15 June 2023 / Accepted: 29 July 2023 / Published: 5 September 2023
Digitalisation as a Prerequisite for the Groundswell Concept Encouraging the Optimisation of Investments in Online Advertising Using an Audit Approach
Authors: Madleňák Adam , Kupec Václav , Hladíková Vladimíra , Písař Přemysl , Kupec Michael 
Published: September 2023

In an environment of hypercompetition, Industry 4.0 and the impact of the social trend called groundswell on corporate communication mediated through social media, online advertising is critical to enterprise marketing. Moreover, the COVID-19 pandemic has accelerated the transformation from classical advertising to digital. The Controlling/Audit approach could serve as a tool for optimising online advertising performance. The paper analyses a sample of online advertisements (n=248,812) and the finding of this research points to possible significant improvement in CPT (Cost per thousand) ratio and enhanced efficiency of enterprise marketing strategies. Based on the research findings, three linear regression models were developed for improving investment in online advertising. These models were used to set up a controlling/audit approach that was experimentally tested in selected enterprises. Experimental testing proved that Controlling/Audit improved the efficiency of online advertising, in some cases, by over 50% in terms of CPT.

Received: 24 June 2023 / Accepted: 23 August 2023 / Published: 5 September 2023
Effect of Personality Traits and Demographics on the Employment Status of Latin American Students
Authors: Barrera-Verdugo Gustavo , Cadena-Echeverría Jaime , Villarroel-Villarroel Antonio , Contreras-Fuenzalida Michelle 
Published: September 2023

Personality traits have been highlighted as factors that affect workers’ behaviour, such as their performance or labour engagement. However, little is currently known about the personality differences between Latin American university students who perform self-employment activities, those who are dependent workers and those who are nonworkers. This research fills this knowledge gap by assessing the influence of the personality traits of 758 university students from Latin America on their employment status. In addition, the effect of gender and age cohort on students’ employment status is assessed. A logistic regression analysis is conducted using the personality traits of the Big Six model, gender and belonging to the millennial generation as independent variables has been conducted. The results support the significant effect of openness, conscientiousness and extraversion on students' employment status. Likewise, effects of gender and age are found. The results contribute to a better understanding of how individual conditions may affect the work activity of university students with regard to dependent employment, self-employment and work inactivity. In addition, the results can guide efforts to support entrepreneurship through the design of effective training programmes according to the students' personality traits and demographic characteristics.

Received: 9 May 2023 / Accepted: 27 July 2023 / Published: 5 September 2023
Female University Entrepreneurship: A Competitive Factor to Strengthen the Professional Profile of Female University Students
Authors: Farroñán Emma Verónica Ramos , Karina Solano Campos Marianela , Ballesteros Marco Agustín Arbulú , León Mabel Ysabel Otiniano , Nuñez Sandra Lizbeth Sánchez , Najera Celín Pérez 
Published: September 2023

Female entrepreneurship has emerged as a topic of great interest in research and society in general. Over the last few years, there has been a significant increase in the number of women starting their own businesses and ventures around the world. Based on this, this article aims to analyze female university entrepreneurship as a competitive factor to strengthen the professional profile of university students. It is framed in a quantitative approach, using a questionnaire based on a Likert scale considering 5 points, with six questions on sociodemographic data and 30 questions divided into 9 dimensions. For its analysis, the Mann Whitney U and Kruskall Wallis tests were used, having as results that entrepreneurial intention (4.44), intrinsic motivation (4.36), attitude (4.32), innovation (4.31), self-efficacy (4.23) and extrinsic motivation (4.20) are the most valued criteria. It is concluded that female university entrepreneurship presents particular characteristics in terms of motivation, financing and entrepreneurial approach. Entrepreneurial university women tend to be business career students, hard-working and thrifty, but they face difficulties in obtaining financing.

Received: 9 May 2023 / Accepted: 30 July 2023 / Published: 5 September 2023
Financial Sustainability Publication Trend: A Bibliometric Study
Authors: Irianto Okto , Adiatma Tini 
Published: September 2023

Financial sustainability is the organization’s capability to maintain the finance in the future to meet its goals. Financial sustainability became an attractive topic in research. ScienceDirect is a website that contains a database of quality research in the world and also publishes many published articles related to the public sector. This study aims to map the trends of publications related to the public sector. This study uses a visualization bibliometric approach, with data obtained from ScienceDirect and then analyzed with VOS Viewer. This study uses the keywords "financial sustainability", the years’ range is 2013 up to 2022, the article type is research articles, and the subject area of (1) economics, econometrics, and finance, and (2) business, management, and accounting found there are 734 articles. Analysis with VOS Viewer with a minimum of related document 25 shows that there are 2 research clusters, with 60 items, 1669 links, and a total link strength of 10656. Research on financial sustainability is very diverse and extensive with almost the same average number, effect related to 232, development 226, evidence, and performance 137, but some areas can still be developed because rarely discussed.

Received: 15 June 2023 / Accepted: 08 August 2023 / Published: 5 September 2023
Cognitive Fitness of Post-Retirement Employees in Control Room Settings
Authors: Damayanti Kristiana Asih , Widyanti Ari , Sari Hasrini , Yassierli  
Published: September 2023

The increasing number of post-retirement workers in the workforce has become a global trend due to efforts to extend the working period after retirement, which is implemented by many countries considering the rapid aging of their populations. While the presence of post-retirement workers can have positive impacts on personal, company, and government levels, they face challenges in interacting with equipment through interfaces that require heavy reliance on cognitive abilities. Cognitive abilities become more important than physical abilities in multitasking jobs that require a lot of interaction with technology, such as control room jobs. These jobs require a high level of attention, concentration, and decision-making ability, making them highly demanding and challenging. This study aims to determine how post-retirement workers meet job demands in the control room, based on identification of critical cognitive abilities. The method employed in this study is divided into two stages. The first stage involves identifying tasks in the control room based on Cognitive Task Analysis (CTA) and identifying critical tasks using risk assessment and Focus Group Discussion (FGD). FGD was conducted on four different types of companies (telecommunication, broadcasting, process industry, and electrical power) that still employ retired workers in the control room jobs. The second stage involves measuring cognitive abilities in 116 individuals aged 56-60 years. The results of CTA indicate there are critical cognitive abilities in control room jobs, such as reasoning, attention, memory, and perception ability. According to the measurement, post-retirement workers (56 - 60 years old) had the problem of improving reasoning, attention, and perceptive ability, despite cognitive capacity measurements remaining in the medium range. In general, post-retirement workers have high memory abilities (above 500), while their abilities in recognition, perception, coordination, and attention are only at 200-400 (a medium level), indicating a decline in cognitive abilities for post-retirement workers. The high memory ability is positive for supporting work in complex systems, while improvement of cognitive abilities is needed for the declining cognitive aspects. Implication of this study were discuss to this paper to consider factors that affect critical cognitive abilities in post-retirement workers when recruiting and training them to work in the control room.

Received: 7 May 2023 / Accepted: 28 July 2023 / Published: 5 September 2023