bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal analysis of the Alternative Healthy Eating Index-2010 and incident non-communicable diseases over 15 years in the 1973–1978 cohort of the Australian Longitudinal Study on Women’s Health
Authors: Hlaing-Hlaing Hlaing , Dolja-Gore Xenia , Tavener Meredith , Hure Alexis J. 
Published: July 2023

AbstractIn studies that contain repeated measures of variables, longitudinal analysis accounting for time-varying covariates is one of the options. We aimed to explore longitudinal association between diet quality (DQ) and non-communicable diseases (NCDs). Participants from the 1973–1978 cohort of the Australian Longitudinal Study on Women’s Health (ALSWH) were included, if they; responded to survey 3 (S3, 2003, aged 25–30 years) and at least one survey between survey 4 (S4, 2006) and survey 8 (S8, 2018), were free of NCDs at or before S3, and provided dietary data at S3 or S5. Outcomes were coronary heart disease (CHD), hypertension (HT), asthma, cancer (except skin cancer), diabetes mellitus (DM), depression and/or anxiety, and multimorbidity (MM). Longitudinal modelling using generalised estimation equation (GEE) approach with time-invariant (S4), time-varying (S4–S8) and lagged (S3–S7) covariates were performed. The mean (± standard deviation) of Alternative Healthy Eating Index-2010 (AHEI-2010) of participants (n = 8022) was 51·6 ± 11·0 (range: 19–91). Compared to women with the lowest DQ (AHEI-2010 quintile 1), those in quintile 5 had reduced odds of NCDs in time-invariant model (asthma: OR (95 % CI): 0·77 (0·62–0·96), time-varying model (HT: 0·71 (0·50–0·99); asthma: 0·62 (0·51–0·76); and MM: 0·75 (0·58–0·97) and lagged model (HT: 0·67 (0·49–0·91); and asthma: 0·70 (0·57–0·85). Temporal associations between diet and some NCDs were more prominent in lagged GEE analyses. Evidence of diet as NCD prevention in women aged 25–45 years is evolving, and more studies that consider different longitudinal analyses are needed.
Homologous recombination mRNAs (RAD21, RAD50 and BARD1) have a potentially poor prognostic role in ERBB2-low bladder cancer patients
Authors: Albarakati Nada , Al-Ghamdi Hanin , Al-Sowayan Batla , Alshareeda Alaa 
Published: July 2023

AbstractHuman epidermal growth factor receptor 2 (HER2/ERBB2) factor is known to be implicated in many malignancies and the potential of it as a prognostic biomarker was reported years ago. Molecular subtypes of HER2/ERBB2 negative and positive with distinct clinical outcomes have been identified in recent years; however, it is still under investigation for bladder cancer. This study evaluates the biological and prognostic significance of RAD21, RAD50 and BARD1 (homologous recombination biomarkers) mRNA levels with ERBB2 low and high expression to explore their impact on bladder cancer patient survival and cancer aggressiveness. The expression of ERBB2, RAD21, RAD50 and BARD1 mRNA levels was assessed in The Cancer Genome Atlas (TCGA) bladder cancer dataset along with four validation cohorts. Outcome analysis was evaluated using disease-free survival (DFS) and overall survival (OS). Univariate and multivariate analysis were used to evaluate the relationship between RAD21, RAD50, BARD1 and ERBB2 expression and clinicopathological variables. A significant increase in mRNA expression levels of RAD21, RAD50 and BARD1 was noticed in ERBB2-low patients compared to ERBB2-high patients. This overexpression of the homologous recombination repair transcripts was associated with poor outcome in ERBB2-low tumors, not in ERBB2-high tumors. Furthermore, the combined expression of high RAD21/RAD50, high RAD21/BARD1 or high RAD50/BARD1 were significantly associated with worse DFS and a better outcome for those with low co-expression in the ERBB2-low cohort. High expression of either RAD21/RAD50 or RAD21/BARD1 in ERBB2-low cohort associated with higher chance of metastasis. In addition, gene expression of BARD1 alone or in combination with RAD50 acted as an independent prognostic factor for worst survival. The data presented in this study reveal a connection between RAD21, RAD50, BARD1 and ERBB2 and patient survival. Importantly, it provided novel findings and potential prognostic markers, particularly in ERBB2-low bladder cancer.
Convergence guarantees for coefficient reconstruction in PDEs from boundary measurements by variational and Newton-type methods via range invariance
Authors: Kaltenbacher Barbara 
Published: July 2023

Abstract
A key observation underlying this paper is the fact that the range invariance condition for convergence of regularization methods for nonlinear ill-posed operator equations—such as coefficient identification in partial differential equations (PDEs) from boundary observations—can often be achieved by extending the searched for parameter in the sense of allowing it to depend on additional variables. This clearly counteracts unique identifiability of the parameter, though. The second key idea of this paper is now to restore the original restricted dependency of the parameter by penalization. This is shown to lead to convergence of variational (Tikhonov type) and iterative (Newton-type) regularization methods. We concretize the abstract convergence analysis in a framework typical of parameter identification in PDEs in a reduced and an all-at-once setting. This is further illustrated by three examples of coefficient identification from boundary observations in elliptic and time-dependent PDEs.
Computational Sentiment Analysis
Authors: Ophir Yotam , Walter Dror 
Published: July 2023

Abstract
This chapter reviews the state of the field of automated sentiment analysis and draws recommendations for available methods and best practices for communication scholars. Introducing and explaining novel methods, from simple dictionary-based approaches to more sophisticated machine learning algorithms, the authors examine the past, present, and potential future of automated sentiment analysis and critically discuss its benefits and limitations, with a particular focus on issues of validity. Acknowledging these important caveats, they discuss the vast potential of big data and computational methods to advance knowledge and theories of emotional communications and demonstrate its applicability using real-world studies of sentiment analysis in communication research.
A novel homozygous missense variant in TBC1D31 in a consanguineous family with congenital anomalies of the kidney and urinary tract (CAKUT)
Authors: Saygılı Seha , Koşukcu Can , Baştuğ Turgut , Doğan Özlem Akgün , Yılmaz Esra Karabağ , Kalyoncu Ayşe Uçar , Ağbaş Ayşe , Canpolat Nur , Çalışkan Salim , Ozaltin Fatih 
Published: July 2023

AbstractCongenital anomalies of the kidney and urinary tract (CAKUT) is the leading cause of chronic kidney disease in the first three decades of life. Until now, more than 180 monogenic causes of isolated or syndromic CAKUT have been described. In addition, copy number variants (CNV) have also been implicated, however, all of these causative factors only explain a small fraction of patients with CAKUT, suggesting that additional yet‐to‐be‐discovered novel genes are present. Herein, we report three siblings (two of them are monozygotic twin) of a consanguineous family with CAKUT. Whole‐exome sequencing identified a homozygous variant in TBC1D31. Three dimensional protein modeling as well as molecular dynamics simulations predicted it as pathogenic. We therefore showed for the first time an association between a homozygous TBC1D31 variant with CAKUT in humans, expanding its genetic spectrum.
Competitiveness of Entrepreneurs and Salaried Workers
Authors: Balafoutas Loukas , Batsaikhan Mongoljin , Sutter Matthias 
Published: July 2023

We measure the willingness to compete of entrepreneurs and salaried workers in an experiment. Participants can choose between a piece rate and a tournament scheme in either private or public. We find that in the private condition, entrepreneurs are less competitive than salaried workers, but in the public condition, this ordering is reversed. Survey data suggest that perceived norms of appropriate behavior, along with beliefs about the instrumental value of competitiveness for professional success, can explain why entrepreneurs are more competitive when decisions are publicly observable. We also find that the latter condition improves the quality of experimental decisions. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Financial support from the Deutsche Forschungsgemeinschaft (German Research Foundation) under Germany´s Excellence Strategy [Grant EXC 2126/1–390838866], the University of Cologne through the Hans Kelsen Prize and the Austrian Science Fund through the Special Research Area [Grant SFB F63] is gratefully acknowledged. Supplemental Material: The online appendix and data are available at https://doi.org/10.1287/mnsc.2023.4838 .
Nachhaltige Nutzung: Mehr als ein neues Schlagwort?
Authors: Haber Wolfgang 
Published: July 2023

Das Konzept der „Nachhaltigkeit“ wird in seiner historischen Entwicklung – von einem forstwirtschaftlichen Konzept bis zu einer der Grundlagen internationaler Umweltpolitik – beschrieben und auf seine Realisierbarkeit aus ökologischer Sicht geprüft. Allen natürlichen Ökosystemen kommt die Eigenschaft „Nachhaltigkeit“ zu, obwohl sie ganz unterschiedlich mit verfügbaren Ressourcen ausgestattet sind und auch Veränderungen (Sukzession) offenstehen. Durch z. T. weltweite Ressourcen-Verschiebungen und Entwicklungs-Beschleunigungen hat der Mensch das gewachsene Ordnungsgefüge der Biosphäre irreversibel verändert. Durch die Einführung des Nachhaltigkeits-Konzepts sind zwar Korrekturen dieser Änderungen, vor allem im regionalen Rahmen möglich (und notwendig), aber keine grundlegende Neuordnung.
STUDY ON THE CHANGE OF THE INTERNAL WAVE AMPLITUDES IN A DISPLACEMENT PROCESS IN THE VIETNAMESE WATERS
Authors: Xuan Nguyen Ba , Chung Tran Van 
Published: July 2023

In this paper some results of calculating and predicting a displacement of the internal wave amplitudes on basis of using the method of solving the equations of the Eigenvalues and Modes of the internal wave are presented. The results show that: the internal waves always displace in space and time with the amplitudes changed.fi-om I m to 35m. The internal waves in the study region have a tendency of increasing the average amplitudes with the depth and reach the maximum values in the layers of 250m, 350m and 450m.
CONSTRUCTION OF BOUGUER GRAVITY ANOMALY MAP IN THE EAST VIETNAM SEA AND ADJACENT AREA
Authors: Que Bui Cong , Dung Tran Tuan , Tram Le 
Published: July 2023

All the gravity data sources in the East Vietnam Sea, which are from the shipboard surveys of Vietnam and foreign countries in the past 50 years to present along with satellite gravity, have been collected. The gravity data have been integrated, analyzed to construct a united Bouguer gravity map at scale of 1:1,000,000 for the whole East Vietnam Sea and adjacent area. The map is constructed in the Mercator WGS-84 projection and digitalized by GIS technique. The homogeneity and accuracy of the map are suitable to scale of 1: 1,000,000 and can be used to different purposes.
INITIAL ESTIMATION ON THE CAUSE OF SPILLED OIL IN THE VIETNAMESE COASTAL ZONE IN THE FIRST HALF OF 2007 YEAR
Authors: Thanh Tran Duc 
Published: July 2023

From January to May 2007, the floating oil attached the coastal areas and some islands of 20 coastal provinces in large scale, from Ha Tinh to the south. The consequences of this event are heavy for forthcoming and long time, meanwhile the cause of spilled oil has been not determined. The existing suppositions can be included into two main groups: Firstly, the causes have been from offshore production sites working or stopping inside or outside of Vietnamese Sea, secondly, the causes are from oil transportation or other navigation activities which purposefully or inpurposefully have dumped oil on their routes, or shipping accidents on the sea. Beside. there are some different opinions, but little persuasion. Based on the analysis of existing information and data, the author of this paper indicates that the cause of the event has been not from any concrete perpetrator at any concrete moment, but from the annually accumulative consequences of wasted oil into the sea from many different sources. From them, the oil wasres and ballast from shipping on the international navigation routes or in harbor waters have been the sources of most importance. The wasted oil of multi-sources has been being accumulated into the slicks concentrating in the determined offshore waters, and floating on the sea after rit e relatively stable currents by seasons. The phenomena of El-Nino lasting from September of last year to present has made the climatic turbulence and changed in hydrological structure of sea. So that, the offshore waters bearing oil slicks has run to coasts and floated oil has been appeared in the large scale.
SOME BIOLOGICAL CHARACTERISTICS OF LONGTAIL TUNA CAUGHT IN THE SEA WATERS OF KHANH HOA PROVINCE
Authors: Phuoc Tran Van 
Published: July 2023

Based on date from length and weight measurements of 218 Longtail tuna samples in the seawaters of Khanh Hoa province. Fork lenght range was from 31 to 49 cm, average 39.13 cm and 40 - 44 cm fork lenght group comprised 39.45%. Weight range was form 550 to 2000 g, average 1090 g and 1250 - 1400 g weight group comprised 19.72%. The Lenght - Weight relationship equation, W = 0.000063L2.7882, R2 = 0.8436; the growth parameters of the Von Bertalanffy equation, Lt = 51.98 (1 – e-0.22t); the total lenght - fork lenght relation equation, Lt = 1.0439Lf + 1.149, R2 = 0.9603. In this research period, 99.3% of both sex having gonads belonged to stage I and II (maturity). Degree of fullness of stomach was very poor - degree of fullness 1, 2 and 3 comprised 87.01% and major species of preys found in stomach of Longtail tuna were major fish, squid and shrimp.
Dormancy-breaking and germination requirements for seeds of the threatened Austral papaya (Carica chilensis)
Authors: Loayza Andrea P. , García-Guzmán Patricio , Carozzi-Figueroa Giovanni , Carvajal Danny E. 
Published: July 2023

Abstract
Seed dormancy is one of the most important adaptive mechanisms in plants, which optimizes germination, seedling emergence, and establishment so that these processes occur when environmental conditions are favorable for plant survival and growth. Endemic to rocky environments of the southern Atacama Desert, the Austral papaya (Carica chilensis) is the papaya species with the southernmost distribution of the Caricaceae and the species growing in the most extreme environmental conditions. This threatened plant has minimal natural regeneration, attributed to low germination rates, but no information regarding seed dormancy release exists. Here we investigated the dormancy-breaking requirements and germination of C. chilensis by assessing the combined effects of desiccation with nine pre-sowing treatments. We hypothesized that, as in other members of the family, C. chilensis seeds would possess physiological dormancy. Our results confirmed this hypothesis and revealed that ultra-drying (< 3% moisture content) and treating seeds with sulfuric acid, gibberellic acid, or potassium nitrate are the most effective methods for germinating C. chilensis. These treatments are thus recommended to propagate this threatened papaya species.
Genetic Innovations Underpin Morphological Diversity and Radiation in Teleost Fish
Authors: He Shunping , Song Yue , Zhang Suyu , Yuan Zengbao , Yang Liandong , Fang Chengchi , Seim Inge , Liu Shanshan , Liu Qun , Wang Cheng , Yang Hengjia , Zhang Yaolei , Pan Zhaohui , Qu Qinming , Pan Luyuan , Chen Xiao , Feng Chen-Guang , Zhu Cheng-Long , Xu Wen-Jie , Wang Jiahao , Liu Meiru , Yu Lili , Zhang Mengqi , Hou Gang , Gan Xiaoni , Zeng Honghui , Lv Meiqi , Wang Mengjun , Gao Haoyang , Zhou Zhuocheng , Yu Mengjun , Li Hanbo , Zhang He , Li Yongxin , Lee Simon Ming-Yuen , Sun Yonghua , Qiu Qiang , Liu Xin , Wang Wen , Chen Yiyu , Wang Jian , Zhu Min , Yang Huanming , Wang Kun , Zhang Guojie , Xu Xun , Fan Guangyi 
Published: July 2023

Abstract

Teleosts, the most species-rich group of jawed vertebrates, have evolved a remarkable diversity of primitive and specialized features that provide a valuable resource for understanding vertebrate evolution. Here, we collected a comprehensive genome dataset of fish, including 115 newly sequenced species, to fill genome gaps for seven orders. By combining the phylogenetic and fossil records of teleosts, we observed that they were relatively scarce from the early to middle Triassic but quickly flourished following the massive extinction event at the end of the Triassic. This rapid radiation coincided with global temperature increases and the fragmentation of Gondwana, implying a positive correlation between temperature rise, tectonic plate movements, and teleost radiations. Our data also revealed that the end-Triassic extinction event had a greater impact on teleost radiation than the Permian-Triassic extinction. We identified a core set of regulatory elements related to aquatic adaptation traits such as swim bladder functional shift and structural specialization of pectoral fin, which were crucial for the adaptation of teleosts to their broad ecological niches. Functional experiments validated the regulatory roles of these conserved elements on the formation of specialized homologous organs in teleosts. Overall, our findings shed light on the links between teleost speciation bursts with geological events, and genetic innovations that have shaped extant teleost biodiversity.
Local Monitoring of Photosensitizer Transient States Provides Feedback for Enhanced Efficiency and Targeting Selectivity in Photodynamic Therapy
Authors: Sandberg Elin , Srambic Chinmaya V , Piguet Joachim , Liu Haichun , Widengren Jerker 
Published: July 2023

Abstract
Photodynamic therapy (PDT) fundamentally relies on local generation of PDT precursor states in added photosensitizers (PS), particularly triplet and photo-radical states. Monitoring these states in situ can provide important feedback but is difficult in practice. The states are strongly influenced by local oxygenation, pH and redox conditions, often varying significantly at PDT treatment sites. To overcome this problem, we followed local PDT precursor state populations of PS compounds, via their fluorescence intensity response to systematically varied excitation light modulation. Thereby, we could demonstrate local monitoring of PDT precursor states of methylene blue (MB) and IRdye700DX (IR700), and determined their transitions rates under different oxygenation, pH and redox conditions. By fiber-optics, using one fiber for both excitation and fluorescence detection, the triplet and photo-radical state kinetics of locally applied MB and IR700 could then be monitored in a tissue sample. Finally, potassium iodide and ascorbate were added as possible PDT adjuvants, enhancing intersystem crossing and photoreduction, respectively, and their effects on the PDT precursor states of MB and IR700 could be locally monitored. Taken together, the presented procedure overcomes current methodological limitations and can offer feedback, guiding both excitation and PDT adjuvant application, and thereby more efficient and targeted PDT treatments.
Is HER2 ultra-low breast cancer different from HER2 null or HER2 low breast cancer? A study of 1363 patients
Authors: Chen Zhaoxu , Jia Huiqing , Zhang Huina , Chen Lifang , Zhao Peng , Zhao Jing , Fu Guangming , Xing Xiaoming , Li Yujun , Wang Chengqin 
Published: July 2023

Abstract
Objective This study aims to analyze whether there are any differences in clinicopathological features and prognosis between HER2 ultra-low, HER2-null and HER2 low expression in Chinese breast cancer (BC) patients. Methods The clinicopathological data of 1363 HER2 negative BC patients were retrospectively collected (from January 2018 to December 2019). HER2 status was further classified into HER2-null, HER2 ultra-low and HER2-low. HER2-null expression is defined as infiltrating cancer cells completely free of staining. HER2 ultra-low expression is defined as ≤ 10% of infiltrating cancer cells showing incomplete and faint/weak membrane staining. HER2-low expression is defined as HER2 IHC 1 + or 2 + with negative ISH assay. Results Of 1363 patients, there were 86 (6.3%) HER2-null patients, 395 (29.0%) HER2 ultra-low patients and 882 (64.7%) HER2-low patients. There were statistically significant differences in histologic type (P = 0.014), histologic grade (P = 0.001), Ki-67 proliferation index (P < 0.001) and postoperative endocrine therapy (P < 0.001) among patients with different HER2 status. In addition, the proportion of hormone receptor (HR) negative BC in HER2-null (72.1%) and HER2 ultra-low (81.0%) was significantly higher than that in HER2-low (12.2%, P < 0.001). The survival analysis showed that HER2 status had no effect on disease-free survival(DFS)in HER2 negative BC patients (log-rank, P = 0.281). However, regardless of HER2 status, HR-positive patients had better DFS than HR-negative patients (log-rank, P = 0.003). Cox multivariate analysis revealed that age (HR [95%CI] = 0.950 [0.928, 0.972], P < 0.001), HR status (HR [95%CI] = 3.342 [1.658, 6.736], P = 0.001) and postoperative endocrine therapy (HR [95%CI] = 0.048 [0.048, 0.023], P < 0.001) were important influencing factors of DFS in HER2-negative BC patients. Conclusion HER2 ultra-low BC patients demonstrated distinct clinicopathological features from HER2-null and HER2-low tumors; while, HER2 status (null, ultra-low or low) had no prognostic value in these HER2 negative BC population. Consistent with the published literature, HR status was an independent prognostic factor for DFS in HER2 negative BC patients.
The synthesis of disubstituted 4-methyl-N,N-dipropylbenzenamine derivatives bearing identical azolethione(thiol) moieties as antioxidant agents
Authors: Tumosienė Ingrida , Jonuškienė Ilona , Belyakov Sergey , Kantminienė Kristina 
Published: July 2023

Abstract
A series of novel 3,3'-(p-tolylazanediyl)di(propanehydrazide) derivatives bearing double sets of thiosemicarbazide, oxadiazolethione, variously N- and S-substituted triazolethione, pyrrole, and hydrazone moieties were synthesized and their molecular structures were confirmed by IR, 1H, 13C NMR spectroscopy and mass spectrometry data. X-ray analysis of 2,2'-((((p-tolylazanediyl)bis(ethane-2,1-diyl))bis(4-phenyl-4H-1,2,4-triazole-5,3-diyl))bis(sulfanediyl))bis(1-(p-tolyl)ethan-1-one) crystal has revealed, that the molecules in the crystal are associated by means of intermolecular hydrogen bonds of OH···N type, forming centrosymmetric dimers. The antioxidant activity of the synthesised compounds was screened by a DPPH radical scavenging assay, reducing power assay, and ferric reducing antioxidant power assay. Among the synthesised compounds, 2,2'-(3,3'-(p-tolylazanediyl)bis(propanoyl))bis(N-phenylhydrazine-1-carbothioamide) has been identified as possessing the highest antioxidant activity, which is 1.25-2 times higher than that of the commercial antioxidant butylated hydroxytoluene.