bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolution of the Council of Experts of May 20, 2023 "Issues of safety in the treatment of a rheumatological patient"
Authors: Alekseeva L. I. , Anoshenkova O. N. , Dolganova N. G. , Zholobova E. S. , Zonova E. V. , Lapshina S. A. , Korolev M. A. , Menshikova L. V. , Shesternya P. A. , Chasovskikh Yu. P. 
Published: August 2023

At the meeting of the Expert Council on May 20, the safety of treatment for patients with osteoarthritis (OA), the most common form of joint disease, was discussed. The first step in the treatment of OA should be the administration of symptomatic delayed-acting agents (SYSADOA) and nonsteroidal anti-inflammatory drugs (NSAIDs). However, given the current understanding of the pathogenesis of inflammation, as well as the fact that it is an active process involving multiple proinflammatory and pro-resolving mediators, it is reasonable to limit the cyclooxygenase-2 suppressive treatment and to include medications with multipurpose effects that contribute to the resolution of inflammation, in particular Zeel® T and Traumeel® S. Traumeel® S affects all stages of inflammation, mostly on the pro-resolving mediators synthesis, and Zeel® T affects chondrogenesis, inflammation, metabolic processes in cartilage tissue and prevents angiogenesis.It was found that it is advisable to use Traumeel® S when it is not possible to prescribe systemic NSAIDs for pain relief. The combination of the proven therapeutic efficacy of Zeel® T and Traumeel® S with a minimal number of adverse events and the absence of interactions with other drugs allows them to be used as an independent treatment regimen for OA.
Analisis Porositas dan Permeabilitas Satuan Batupasir Formasi Ledok sebagai Potensi Batuan Reservoir Daerah Kedewan dan Sekitanya Bojonegoro, Jawa Timur
Authors: Yuwanto Sapto Heru , Rosadi Muhammad Zulvi 
Published: August 2023

Daerah penelitian terletak pada Zona Rembang, secara administratif yaitu Desa Beji dan sekitarnya, Kecamatan Kedewan, Kabupaten Bojonegoro, Provinsi Jawa Timur. Maksud dari penelitian ini adalah mengetahui kondisi geologi, geomorfologi, stratigrafi, struktur geologi, sejarah geologi, serta kualitas porositas dan permeabilitas untuk penentuan batuan reservoir pada daerah penelitian. Pada penelitian geologi kali ini dilakukan dengan penelitian permuakaan daerah penelitian, sedangkan analisis yang dilakukan adalah analisa petrografi, analisa mikropaleontologi analisis struktur geologi, analisis stratigrafi dan analisis sifat inti batuan yang menggunakan metode penimbangan serta sayatan tipis untuk mengetahui nilai porositas dan metode pengukuran dengan alat permeameter untuk mengetahui nilai permeabilitas batuoasr firmasi ledok.Geomorfologi pada daerah penelitisn dapat dibagi menjadi yaitu struktural dan denudasional untuk denudasional sendiri kita dapat membagi lagi menjadi dua klasifikasi yaitu D4, D5 untuk denudasional dan S5untuk satuan struktural. Susunan Stratigrafi dari yang paling tua ke yang mudah yaitu Satuan Batuan Batu Kalkarenit, Satuan Batuan Napal sisipan kalkarenit, Satuan Batupasir, dan Satuan Batuan Napal. Struktur geologi daerah penelitian yaitu Antiklin Kedewan, Antiklin Beji, Sesar Geser Kiri Diperkirakan. Rata-rata Porositas Satuan Batuan Batupasir Ledok dengan nilai rata-rata 34,665% (istimewa) dan nilai permeabilitas memiliki rata-rata 76,58133mD (baik), Maka dapat disimpulkan satuan Batuan BatupasirLedokberpotensi menjadi reservoir yang baik.
Inventarisasi Geoheritage Potensi Kawasan Geowisata Daerah Tongkuno, Pulau Muna, Provinsi Sulawesi Tenggara
Authors: Hasria Hasria , Karim Ham , Asfar Suryawan 
Published: August 2023

Daerah Tongkuno yang termasuk dalam Peta Geologi Lembar Buton Formasi Wapulaka dan merupakan bagian dari kars Pulau Muna, Provinsi Sulawesi Tenggara, memiliki potensi keanekaragaman fenomena geologi yang dapat dikembangkang sebagai kawasan geowisata. Tujuan penelitian ini untuk menginventarisasi geoheritage potensi geowisata dan menentukan site (lokasi) serta geotrek yang ada di daerah Tongkuno Kabupaten Muna, Provinsi Sulawesi Tenggara. Metode yang digunakan terdiri dari pengamatan dan pengambilan data lapangan. Pengambilan data lapangan meliputi data litologi penyusun geosite, data geomorfologi/topografi geosite, titik koordinat geosite, akses menuju lokasi geosite, kondisi infrastruktur daerah geowisata, serta kesampaian waktu menuju geosite. Hasil studi ini menunjukkan bahwa Daerah Tongkuno memiliki 3 (tiga) geosite yakni Geosite Walengkabola, Geosite Labora dan Geosite Kotanowuna. Geosite Walengkabola memiliki keunikan berupa danau dolin, pantai bergisik, gua mata air, gua bawah laut serta hamparan terumbu karang yang indah serta terdapat stalagtit dan stalagmit, limestone cliff, gordyn karst, ponor, pits, serta karren. Geosite Labora memiliki keunikan berupa tanjung yang memiliki bentuk memanjang dan mendatar membentuk teras yang dibatasi oleh tebing-tebing gamping yang terjal. Pada dinding tebing terdapat ornamen-ornamen berupa fitur geologi minor seperti pits dan pans, rill karren, protocave, gordyn, dan karst dan pada kaki tebing dekat pantai terdapat gua dengan ornamen berupa stalagtit dan stalagmit, kristal kalsit dan mata air. Geosite Kotanowuna memiliki keunikan berupa perbukitan karst dengan berbagai macam bentuk seperti menara kars, bukit kars terisolir, bukit yang menyerupai kapal, bukit poligonal dan terdapat pedataran kars, karren field dan terraa rosa serta uvala juga fitur-fitur budaya seperti Masjid Muna yang merupakan pusat kerajaan Muna di masa lampau, Benteng kota muna yang mengelilingi kerajaan muna, makam raja dan keluarga raja, serta batu pelantikan raja. Site/lokasi geowisata di daerah penelitian dapat ditempuh dengan penjalanan darat menggunakan kendaraan roda empat. Kajian potensi geowisata daerah Tongkuno diharapakan dapat menjadi suatu upaya dalam menggali informasi mengenai potensi-potensi geologi yang dapat dikembangkan sebagai objek geowisata.
Developing and evaluating a multiple-choice knowledge test about Brønsted-Lowry acid-base reactions for upper secondary school students
Authors: Krebs Rita Elisabeth , Rost Marvin , Lembens Anja 
Published: August 2023

Abstract
For centuries, chemists have researched acid-base reactions and developing numerous different acid-base concepts. Consequentially, it is difficult to teach about acid-base reactions in a clear and conceptually coherent manner. We aim at contributing to teaching about acid-base chemistry by an intervention introducing upper secondary school chemistry students to an acid-base concept that is scientifically appropriate and learner-centred. This modernized version of the Brønsted-Lowry acid-base concept appears sufficiently complex for the target group. Additionally, it emphasizes the donor-acceptor concept and the reaction mechanism. In order to evaluate the gain in declarative knowledge during our intervention, we developed and piloted a multiple-choice knowledge test with Austrian upper secondary students (N = 136). By estimating a Rasch model (WLE-Rel. = 0.63, Infitmin = 0.90, Infitmax = 1.02, Outfitmin = 0.89, Outfitmax = 1.00, d = −0.44–1.8), we constructed a pre-test (11 MC items, 6 open-ended questions) and a post-test (11 MC items, 6 open-ended questions) based on key concepts of the topic for our intervention study (N = 57). Overall, the test proved a reliable tool to estimate learners’ declarative knowledge about acid-base reactions in the course of the intervention study, showing a significant knowledge increase.
Adopting a new approach for finding missing people using GIS techniques: A case study in Saudi Arabia’s desert area
Authors: Almujalli Faisal Sulaiman , Altuwaijri Hamad Ahmed 
Published: August 2023

Abstract
Every year, hundreds of people go missing in the wilderness of Saudi Arabia. There is an urgent need to examine modern geographic techniques for finding such people. Geographical information systems, for example, play a crucial role in wilderness search and rescue (WiSAR), not only in mapping probability areas but also in applying further analysis and modeling methods to reduce time and effort and to guide life-saving task forces in the right direction. In this study of a hypothetical missing-person case in Saudi Arabia, two standard WiSAR models are compared: ring and mobility. In the presented study situation, both models can be used. However, the new approach used in the mobility model drastically reduces the extent of the possible search area, from 101,787 km2 in the ring model to 335.34 km of likely trails and unpaved roads, and also provides exact directions to where the missing person may be found.
Characterization of bio-oil production by microwave pyrolysis from cashew nut shells and Cassia fistula pods
Authors: Waitongkham Ratima , Pianroj Yutthapong , Punvichai Teerasak , Karrila Seppo , Chumkaew Parinuch , Jumrat Saysunee 
Published: August 2023

Abstract
In this study, the production of bio-oil by pyrolysis with microwave (MW) heating was tested experimentally. Two magnetrons with a total MW power of 1,600 W were used in the pyrolysis setup. The electric field strength was 185.38 V·m−2 at an MW frequency of 2.45 GHz. Cashew nut shells (CNS) or Cassia fistula pods (CFP) were pyrolyzed at 400°C, 500°C, or 600°C, with biomass-to-activated carbon ratio set at 70:30, 80:20, or 90:10. The largest yield of bio-oil was found for CNS at 600°C, and for CFP at 500°C, both with 90:10 ratio, achieving, respectively, 20.0% and 15.8% yields. When the bio-oil yields from CNS and CFP at 90:10 ratio and 400–600°C were analyzed with gas chromatograph-mass spectrometer, the components found included acids, esters, ketones, furans, pyrans, guaiacol, syringol and phenols, and phenolic derivatives were the dominant type of compounds. There were 23.56% and 13.23% phenolic derivatives, respectively, in the bio-oils from CNS (at 500°C) and from CFP (at 400°C). An analysis with Folin–Ciocalteu reagent of the phenolic contents in bio-oils gave the respective ranges 146.83–164.83 mg·GAE·g·DW−1 and 39.34–45.91 mg·GAE·g DW−1 for CNS and CFP (both run with 90:10 ratio).
Helical fluorinated carbon nanotubes/iron(iii) fluoride hybrid with multilevel transportation channels and rich active sites for lithium/fluorinated carbon primary battery
Authors: Chen Gaobang , Cao Feng , Li Zexiao , Fu Jianan , Wu Baoshan , Liu Yifan , Jian Xian 
Published: August 2023

Abstract
Lithium/fluorinated carbon (Li/CF
x
) primary battery is a promising energy supply device with high energy density. However, poor electrochemical capabilities such as the initial voltage delay phenomenon and the large polarization have obstructed their applications. The electrochemical performance of CF
x
primarily depends on the feature of the carbon source and the corresponding fluorination technique. Herein, we developed a high energy density Li/CF
x
battery by employing helical carbon nanotubes (HCNTs) as the carbon source. In detail, the precise control of the fluorination temperature was designed at the range of 250–400°C to tune the F/C ratio of CF
x
. Furthermore, the high F/C ratio of fluorinated HCNTs (F-HCNTs) reaches about 1.43, which surpasses the highest theoretical value in fluorinated crystalline carbon materials. Due to the active rich fluorination sites provided by the periodical insertion of the carbon pentacyclic (C5) and heptacyclic (C7) rings, HCNTs exhibited a defect-rich feature and F-HCNTs have a nodular shape. These features favor to enhance the transport of lithium ions and allow more C–F bonds to react with lithium ions, leading to a high energy density of 2133.13 W h/kg. This novel material offers an alternative approach for lithium primary battery being great potential in actual applications.
Semi-automatic COVID-19 vaccine preparation for upscaling of vaccination: a descriptive study
Authors: van der Nat Denise J. , Lindemans Anouk D. , van Rijn Laurens C. , Ruijgrok Elisabeth J. 
Published: August 2023

Abstract

Objectives
Vaccines are used on a large scale for prevention of disease. Preparing vaccines for administration can be a time consuming process. To increase efficacy of vaccine administration, the Vaxtractor was designed in January 2021. With the Vaxtractor, the desired volume of vaccine is drawn up automatically in syringes from two vials of vaccine simultaneously. We examined the quality of COVID-19 vaccines prepared with the Vaxtractor.

Methods
Sterility tests and uniformity of dosage units tests were performed. For the sterility test, 22 syringes were filled with 0.5 mL Tryptic Soy Broth and these were incubated at 25 °C for seven days followed by seven days at 30 °C. For the dosage unit test, the difference between the filled and empty syringe was used to compute the volume of the injectable volume. A time analysis was performed on manually and semi-automatically prepared vaccines.

Results
The sterility tests showed no signs of growth of micro-organisms. After optimizing the Vaxtractor, none of the Comirnaty® vaccines deviated more than 10 % and none of the Spikevax® vaccines deviated more than 5 % compared to the mean mass of the injectable volume. The acceptance value for uniformity of dosage units of both vaccines was below 4 (requirement <15). Preparing vaccines with the Vaxtractor was faster compared to manually prepared vaccines.

Conclusions
The Vaxtractor can be used to safely prepare Spikevax® and Comirnaty® vaccines. Further studies should explore the applicability of the Vaxtractor for the preparation of other vaccines. If applicable, this will contribute to effective upscaling of vaccination programs.
Optimization of eggshell particles to produce eco-friendly green fillers with bamboo reinforcement in organic friction materials
Authors: Sunardi Sunardi , Ariawan Dody , Surojo Eko , Prabowo Aditya Rio , Akbar Hammar Ilham , Sudrajad Agung , Seputro Harjo 
Published: August 2023

Abstract
The environment is a very important topic today as well as in the future. One source of air pollution that has the potential to harm health is the wear particles released by vehicle braking systems. If these wear particles come from hazardous materials, they could destroy human health and the environment. Based on these conditions, exploring more environmentally friendly materials to substitute hazardous materials as friction materials is necessary. In this study, brake linings were prepared from bamboo fiber and eggshell (ES) particles with various pre-treatment conditions. The composition of the material frictions consisted of phenolic resin, bamboo fiber, bamboo particles, ES particles, zinc, alumina, and graphite in the following: 35% phenolic resin, 10% graphite, 10% bamboo fiber, 10% alumina powder, 5% zinc powder, and 30% bamboo particles and ESs. This study focused on observing the mechanical and tribological behavior of friction materials when using ES particles as fillers. There are three stages to manufacturing friction material: a cold press, a hot press, and heat treatment. The optimization of the characteristics of ESs as organic brake linings was carried out using the Taguchi method and analyzed using data envelopment analysis-based ranking (DEAR). An interesting finding from this study was that when ES particles were calcined at 900°C for 120 min, the ES particle size was 200 mesh, and the ES volume fraction at 25% resulted in the most optimal brake lining performance. Calcination at 900°C for 120 min completely changed the CaCO3 phase to CaO. This study also shows that calcined ES particles have the potential to be developed as friction materials for environmentally friendly two-wheeled vehicles in the future. The produced brake linings exhibited hardness, a coefficient of friction, and specific wear rates of 92.82 HR, 0.32, and 4.43 × 10−6 mm3·N−1·m−1, respectively.
A Nyitott ház —előtér kísérletek: Konténerizáció a közművelődés tereiben
Authors: Dóri Éva 
Published: August 2023

A tanulmány szerves részét képezi egy, a Nyitott ház Kollégium tevékenységét és szakmai eredményeit kutató munkának. Az 1970-es évek közepén felerősödött szakmafejlesztői szemléletmód a közművelődés fizikai tereinek és a művelődési formák megújítására irányult. A Népművelési Intézet által életre hívott szakmai innovációs kísérletek a Nyitott ház mozgalomban bontakoztak ki.
Az intézmények adottságainak és funkcióinak, tevékenységrendszerének újragondolását elsődlegesen a szűkös szakmai erőforrások ösztönözték. Az alkalmi és az állandó művelődési lehetőségek megkülönböztetéséből eredő elméleti program gyakorlati modellezésére 1976-1978 között a csepeli Rideg Sándor Művelődési Házban került sor. A konténerizáció folyamatosan biztosítható, kötetlen, az egyén részéről aktívitást igénylő tevékenység-lehetőségekre irányult. A progresszív, szemléletváltó gyakorlat nem tudott meghonosodni hazánkban. Ugyanakkor a Magyarországon több, mint 40 évvel ezelőtt zajló előtér kísérletek a napjainkban „markerspace” (“munkaterület”) néven világszerte elterjedt közösségi „tevékenység-terek” sajátos előképének is tekinthetők. A kutatás korabeli publikációkra épül.
Nagykanizsai kultúraközvetítő intézményekben dolgozó alkalmazottak kulturális fogyasztási szokásai
Authors: Kománovics Alexandra 
Published: August 2023

Jelen tanulmány célja, hogy bemutassa az öt vizsgált nagykanizsai kultúraközvetítő intézmény dolgozóinak kultúrafogyasztási szokásait. A kutatásból megtudható, hogy a dolgozók elégedettek-e a városban elérhető kulturális szolgáltatásokkal és azokat igénybe veszik-e, illetve részt vesznek-e a saját és a többi kultúraközvetítő intézmény programjain. Két hipotézist határoztunk meg: H1: Az öt vizsgált intézmény alkalmazottjai azért nem járnak szívesen a saját és a többi intézmény rendezvényeire, mert kevés szabadidejük van és túlságosan leterheltek. H2: Az öt intézmény dolgozóinak vizsgált köre szívesebben jár el más városba kulturális célzattal azért, mert nincsenek megelégedve a város kulturális kínálatával.
Rétegzett mintavételi eljárást alkalmazva, három csoport kialakítását követően véletlenszerű kiválasztással 30 strukturált interjút vettünk fel 2022 őszén. Kiderült, hogy a vizsgált interjúalanyok kevés szabadidő lévén is szívesen látogatják a saját és a többi intézmény programjait, a legjobban a színházi előadások és a koncertek iránt érdeklődnek. A visszalátogatás egyik oka, hogy többen a munkájukra hobbiként tekintenek, a másik pedig, mert közös program a kollégákkal. A válaszadók nagy része mindent összevetve elégedett Nagykanizsa kulturális kínálatával, mégis szívesen utazik el más városokban egy-egy kulturális műsorért, ugyanakkor innovációs javaslatokat is megfogalmaztak. A kutatás eredménye hasznos lehet az öt vizsgált kultúraközvetítő intézmény statisztikai adatbázisának bővítésére, illetve a kulturális szolgáltatások fejlesztésére. Az országos statisztikához is hozzájárulhat, ezzel segítve a Nemzeti Művelődési Intézet szakmai munkáját.
INVESTIGATION OF BACTERIAL AND VIRAL SLOW INTERVERTEBRAL DISC INFECTIONS
Authors: Isroilov Somon Kurbonovich , Shigapov Marsel Albertovich , Murasov Artur , Kuzhabaeva Aliya Gumerovna , Nikonorov Kirill , Skudarnova Maria Vyacheslavovna 
Published: August 2023

Objective. Currently, few publications have been available regarding an effect of level, type of intrusion, and viral infections on spinal disc degeneration. The study was aimed to evaluate an incidence of indolent bacterial and viral intervertebral disc infections in unstratified group of patients operated on for spinal degenerative pathologies.
Material and methods. For the study, intraoperative disc samples were collected from patients who underwent discectomy and total spinal fusion surgery for degenerative pathologies between the years December, 2018 to January, 2020. 447 samples were examined obtained from 392 patients (189 women and 203 men) with a mean age of 58.1 years.
The following epidemiological and clinical data were collected: gender, age, spinal segments affected, type of surgical approach, preoperative C-reactive protein (CRP; reference range 0.00.5 mg/dL), and preoperative as well as 6-month postoperative ODI and NDI, both expressed as a percentage. The incidence of postoperative infections within six months after surgery as well as MI for each operated segment was assessed. Only patients with ventral cervical or dorsal thoracic access were enrolled in the study. In the lumbar region, the ventral assess was chosen for anterior lumbar interbody fusion, the lateral approach for oblique or extreme lateral interbody fusion, and the dorsal approach in case of standard microdiscectomy of posterior transforaminal interbody fusion or transforaminal interbody fusion.
A logistic regression analysis was performed to model a risk of positive microbiological culture and a risk of emerging modal changes by using a set of independent variables selected in a stepwise manner by using the Akaike information criterion as a measure of quality of select procedure.
Results. MRI for modal analysis was available for all 447 segments. MRI revealed 45 type 1 SCs (10.07% of all segments), 118 type 2 SCs (26.4%), and 5 type 3 SCs (1.12%). Microbiological culture was available in 410 segments. In these 410 segments, 39 type 1 MCs, 113 type 2 MCs, and 5 type 3 MCs were found. A statistically significant relationship was found between SC type 2 and a positive microbiological result (p = 0.0127). In contrast, there were no statistically significant associations for type 1 and type 3 SCs (p=0.3052 and p=0.0767, respectively).
Conclusion. A relation between disc degeneration and infections seems unlikely. Histopathological evidence of inflammation in degenerated discs is rare and unrelated to microbiological findings.
«Jeg er redd for fremtiden»
Authors: Andersen Ida Vikøren 
Published: August 2023

Sammendrag
Mange unge er bekymret for klimaendringene. Her undersøker jeg innholdet i denne bekymringen, som uttrykt i debattartikler skrevet av ungdom til Aftenposten mellom 2016-2021. Min analytiske tilgang til disse tekstene er retorisk, noe som innebærer at jeg undersøker hvordan følelsene uttrykkes, begrunnes og inviterer en bestemt respons. Jeg finner at skribentenes uro enten uttrykkes som en generell bekymring for menneskeheten i en fjern fremtid eller en konkret bekymring for skribentenes egen fremtid. Uroen begrunnes i kunnskap om situasjonens alvor og opplevelsen av de ansvarlige gjør lite for å løse problemene. De fleste følelsesuttrykkene har en deliberativ orientering: De inviterer publikum til å handle for å løse problemet. Mange har også en epideiktisk orientering: De inviterer publikum til å bekrefte verdiene skribentene promoterer. I enkelte innlegg har imidlertid følelsesuttrykkene en privat orientering og en performativ funksjon: De henleder publikums oppmerksomhet mot skribenten og skribentens følelser, heller enn mot situasjonen som adresseres.
Abstract

Abstract
In this paper, I examine the content of young Norwegians’ climate concerns, as expressed in debate articles written by young people between 2016-2021. Using rhetorical analysis, I explore how the youth articulate and justify their worry and how these articulations invite specific responses. The young writers’ climate concern is either articulated as a general concern for humanity’s survival in a distant future or a concrete concern for the youths’ own and temporally close future due to political inaction to act upon climate change. The articulation of worry is primarily characterised by deliberative and epideictic rhetoric, as the audience is invited to act upon the problem addressed and confirm the values promoted by the youth. However, in some articles, the articulation of worry primarily draws the audience’s attention to the young writers’ personal emotions rather than the situation addressed.