bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute appendicitis and situs viscerum inversus: radiological and surgical approach—a systematic review
Authors: Di Buono Giuseppe , Buscemi Salvatore , Galia Massimo , Maienza Elisa , Amato Giuseppe , Bonventre Giulia , Vella Roberta , Saverino Marta , Grassedonio Emanuele , Romano Giorgio , Agrusa Antonino 
Published: February 2023

AbstractIntroductionAcute appendicitis is one of the most frequent intra-abdominal diseases requiring emergency surgical consult and treatment. The diagnosis of this condition is based on clinical features and radiologic findings. One-third of patients with acute appendicitis present unusual symptoms. There are several circumstances that may cause misdiagnosis and unclear prognostic prediction. Among these, situs viscerum inversus totalis and midgut malrotation can be challenging scenarios, leading to a delay in treatment, especially when these conditions are unknown. We decided to carry on a systematic review of published cases of acute appendicitis in the context of anatomical anomalies.MethodsWe used the MESH terms “appendicitis” AND “situs inversus” AND/OR “gut malrotation” to search for titles and abstracts. Inclusion criteria were patients with clinical and/or radiological diagnosis of acute appendicitis, with conservative or surgical management and with preoperative/intraoperative findings of situs viscerum inversus or gut malrotation. Additionally, previous reviews were examined. Exclusion criteria of the studies were insufficient patient clinical and demographic data.ResultsWe included in this review 70 articles concerning 73 cases of acute appendicitis with anatomical anomaly. Patients were aged from 8 to 86 years (median: 27.0 years). 50 were male and 23 were female. 46 patients (63%) had situs viscerum inversus, 24 (33%) had midgut malrotation, 2 (2.7%) had Kartagener’s syndrome, one of them (1.4%) had an undetermined anomaly In 61 patients the anatomical anomaly was unknown previously (83.6%), while 16,4% already were aware of their condition.ConclusionAcute appendicitis can occur in association of rare anatomical anomalies and in these cases diagnosis can be challenging. Situs viscerum inversus and midgut malrotation should always be considered in the differential diagnosis of a patient with left lower quadrant pain, especially in younger population. Besides clinical features, it is fundamental to implement the diagnostic progress with radiological examination. Laparoscopic approach is useful to identify and treat acute surgical emergency and it is also a diagnostic tool and can be tailored in order to offer the best exposition of the operatory field for each single case.
Neurofibromatosis-Noonan syndrome and growth deficiency in an Iranian girl due to a pathogenic variant in NF1 gene
Authors: Dalili Setila , Hoseini Nouri Seyyedeh Azade , Bayat Reza , Koohmanaee Shahin , Tabrizi Manijeh , Zarkesh Marjaneh , Tarang Alireza , Mahdieh Nejat 
Published: February 2023

Abstract
Background
Mutations in NF1 gene could cause allelic disorders with clinical spectrum of Neurofibromatosis type 1 to Noonan syndrome. Here, a 7-year-old Iranian girl is described with Neurofibromatosis-Noonan syndrome due to a pathogenic variant in NF1 gene.

Methods
Clinical evaluations were performed along with genetic testing using whole exome sequencing (WES). The variant analysis including pathogenicity prediction was also done using bioinformatics tools.

Results
The chief compliant of the patient was short stature and lack of proper weight gain. Other symptoms were developmental delay, learning disability, inadequate speech skill, broad forehead, hypertelorism, and epicanthal folds, low set ears and webbed neck. A small deletion, c.4375-4377delGAA, was found in NF1 gene using WES. This variant was classified as pathogenic according to ACMG.

Conclusions
NF1 variants may show variable phenotypes among the patients; identifying such variants is helpful in therapeutic management of the disease. WES is considered as an appropriate test to diagnose Neurofibromatosis-Noonan syndrome.
The mother–daughter Shared Agency in Weight Management Scale (SAWMS): development, validation, and implications for body dissatisfaction
Authors: Shao Jianmin , Chang Esther S. , Tsong Yuying , Chen Chuansheng , Borelli Jessica L. 
Published: February 2023

Abstract
Background
Much research suggests that mothers play an important role in shaping daughters’ body image, yet less is known about how mother–daughter relationship dynamics in weight management affect daughters’ body dissatisfaction. The current paper described the development and validation of the mother–daughter Shared Agency in Weight Management Scale (SAWMS) and examined its associations with daughter’s body dissatisfaction.

Methods
In Study 1 (N = 676 college students), we explored the factor structure of the mother–daughter SAWMS and identified three processes (control, autonomy support, and collaboration) whereby mothers work with daughters in weight management. In Study 2 (N = 439 college students), we finalized the factor structure of the scale by conducting two CFAs and assessing the test–retest reliability of each subscale. In Study 3 (same sample as Study 2), we examined the psychometric properties of the subscales and their associations with daughters’ body dissatisfaction.

Results
Combining results from EFA and IRT, we identified three mother–daughter dynamics in weight management—maternal control, maternal autonomy support, and maternal collaboration. However, based on various empirical results indicating poor psychometric properties of the maternal collaboration subscale, we removed it from the mother–daughter SAWMS and only evaluated the psychometric properties of the remaining two subscales (i.e., control and autonomy support). They explained a significant amount of variance in daughters’ body dissatisfaction over and above the effect of maternal pressure to be thin. Maternal control was a significant and positive predictor of daughters’ body dissatisfaction; maternal autonomy support was a significant and negative predictor.

Conclusions
Results suggested that maternal control in weight management was associated with daughters’ increased body dissatisfaction, whereas maternal autonomy support in weight management was associated with daughters’ lower body dissatisfaction. These specific ways in which mother work with daughters in weight management provide nuances in understanding young women’s body dissatisfaction. Our SAWMS offers new ways to examine body image among young women through the mother–daughter relationship dynamics in weight management.
Oseltamivir phosphate for suspension is bioequivalent to TAMIFLU in healthy volunteers: a randomized, open-label clinical study
Authors: Wang Ying , Tang Bangzhong , Xie Jing , Wang Xiaoqin , Ren Peng , Wu Guangmei , He Cuixia , Zhu Minhui , Su Yue , Ding Jiaxiang , Xu Yuanyuan , Fan Ling , Ge Qin , Ding Yuzhou , Zhu Juan , Liu Bingyan , Shan Rongfang , Zhou Huan 
Published: February 2023

Abstract
Purpose
The study was aimed at evaluating the bioequivalence and safety of oseltamivir phosphate for suspension, provided by Shenzhen Beimei Pharmaceutical Co. Ltd. and manufactured by Hetero Labs Limited, and the reference product TAMIFLU® in healthy Chinese subjects.

Methods
A single-dose, randomized, two-phase, self-crossed model was adopted. Among 80 healthy subjects, 40 subjects in the fasting group and 40 subjects in the fed group. Subjects in the fasting group were randomized into two sequences according to the proportion of 1:1, each given 75 mg/12.5 mL of Oseltamivir Phosphate for Suspension or TAMIFLU®, and cross-administered after 7 days. Postprandial group is the same as fasting group.

Results
The Tmax of TAMIFLU® and Oseltamivir Phosphate for Suspension in the fasting group were 1.50 h and 1.25 h, which in the fed group were both 1.25 h. Geometrically adjusted mean ratios of the PK parameters of Oseltamivir Phosphate for Suspension along with TAMIFLU® under fasting and postprandial conditions were in the range of 80.00–125.00% at the 90% confidence interval (CI). The 90% CI of Cmax, AUC0-t, AUC0-∞ for fasting group and postprandial group were (92.39,106.50), (94.26,100.67), (94.32,100.89) and (93.61,105.83),(95.64,100.19),(96.06,102.66). Among the subjects on medication, a total of 18 subjects reported 27 adverse events, all of which were treatment-emergent adverse events (TEAEs), six of these TEAEs were rated as grade 2 in severity and the rest were as grade 1. The number of TEAEs in the test product and the reference product were 14,13 respectively.

Conclusion
Two Oseltamivir phosphate for suspensions are safe and bioequivalent.
Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice
Authors: Groveman Bradley R. , Race Brent , Foliaki Simote T. , Williams Katie , Hughson Andrew G. , Baune Chase , Zanusso Gianluigi , Haigh Cathryn L. 
Published: February 2023

AbstractHuman cerebral organoids (COs) are three-dimensional self-organizing cultures of cerebral brain tissue differentiated from induced pluripotent stem cells. We have recently shown that COs are susceptible to infection with different subtypes of Creutzfeldt–Jakob disease (CJD) prions, which in humans cause different manifestations of the disease. The ability to study live human brain tissue infected with different CJD subtypes opens a wide array of possibilities from differentiating mechanisms of cell death and identifying neuronal selective vulnerabilities to testing therapeutics. However, the question remained as to whether the prions generated in the CO model truly represent those in the infecting inoculum. Mouse models expressing human prion protein are commonly used to characterize human prion disease as they reproduce many of the molecular and clinical phenotypes associated with CJD subtypes. We therefore inoculated these mice with COs that had been infected with two CJD subtypes (MV1 and MV2) to see if the original subtype characteristics (referred to as strains once transmitted into a model organism) of the infecting prions were maintained in the COs when compared with the original human brain inocula. We found that disease characteristics caused by the molecular subtype of the disease associated prion protein were similar in mice inoculated with either CO derived material or human brain material, demonstrating that the disease associated prions generated in COs shared strain characteristics with those in humans. As the first and only in vitro model of human neurodegenerative disease that can faithfully reproduce different subtypes of prion disease, these findings support the use of the CO model for investigating human prion diseases and their subtypes.
Extraction, structure characterization and biological activity of polysaccharide from coconut peel
Authors: Zhou Shiyang , Huang Gangliang 
Published: February 2023

AbstractTaking coconut peel as raw material, the extraction process of coconut peel polysaccharide (CPP) was optimized by boiling water extraction. The coconut peel polysaccharide was characterized by UV, IR, SEM, 1D NMR and 2D NMR spectra. At the same time, the molecular weight and monosaccharide component were analyzed by gel chromatography and ion chromatography, respectively. Antioxidant activity of coconut peel polysaccharide and its derivatives in vitro was evaluated by scavenging ABTS and DPPH radicals and O2−·, and the anti HepG2 proliferation activity in vitro was also carried out. The results showed that the molecular weight of coconut peel polysaccharide was 1.20 × 105 Da, which was mainly composed of arabinose (Ara), galactose (Gal), glucose (Glu), xylose (Xyl) and galacturonic acid (Gal-A). The main chain structure of polysaccharides detected by 1D and 2D NMR spectrum was → 4)-α-D-Glcp (1 → . In vitro antioxidant test showed that coconut peel polysaccharide and its derivatives had a certain scavenging effect on ABTS and DPPH free radical and O2−·. With the increase of polysaccharide concentration, the scavenging ability was gradually increased. In addition, coconut peel polysaccharide and its derivatives showed significant antiproliferative activity against HepG2 cells in vitro.
Graphical Abstract
Machine-learning-assisted analysis of transition metal dichalcogenide thin-film growth
Authors: Kim Hyuk Jin , Chong Minsu , Rhee Tae Gyu , Khim Yeong Gwang , Jung Min-Hyoung , Kim Young-Min , Jeong Hu Young , Choi Byoung Ki , Chang Young Jun 
Published: February 2023

AbstractIn situ reflective high-energy electron diffraction (RHEED) is widely used to monitor the surface crystalline state during thin-film growth by molecular beam epitaxy (MBE) and pulsed laser deposition. With the recent development of machine learning (ML), ML-assisted analysis of RHEED videos aids in interpreting the complete RHEED data of oxide thin films. The quantitative analysis of RHEED data allows us to characterize and categorize the growth modes step by step, and extract hidden knowledge of the epitaxial film growth process. In this study, we employed the ML-assisted RHEED analysis method to investigate the growth of 2D thin films of transition metal dichalcogenides (ReSe2) on graphene substrates by MBE. Principal component analysis (PCA) and K-means clustering were used to separate statistically important patterns and visualize the trend of pattern evolution without any notable loss of information. Using the modified PCA, we could monitor the diffraction intensity of solely the ReSe2layers by filtering out the substrate contribution. These findings demonstrate that ML analysis can be successfully employed to examine and understand the film-growth dynamics of 2D materials. Further, the ML-based method can pave the way for the development of advanced real-time monitoring and autonomous material synthesis techniques.Graphical Abstract
Gender gaps in grades versus grade penalties: why grade anomalies may be more detrimental for women aspiring for careers in biological sciences
Authors: Malespina Alysa , Singh Chandralekha 
Published: February 2023

AbstractBackgroundIn the US, bioscience programs now often have more women than men who earn degrees at all levels. Despite this, evidence still exists for gender inequity in bioscience and medical fields. For example, women with careers in these fields tend to get paid less and leave these fields more. Here, we present research investigating grade penalties. Grade penalties describe the difference between a students’ grade point average and grade in a particular course when a students’ grade in a class is lower than their grade point average (GPA). For example, a student has a grade penalty of 1 in a course if their GPA is 3.0 (B) and they receive a 2.0 (C) in the course. We hypothesize that grade penalties in these STEM courses can affect students’ STEM-related self-concept negatively with potentially long-term consequences, e.g., in students’ career choices. We investigated grade penalties in science courses for undergraduate students studying biosciences. We propose a framework that posits that students who receive grade penalties in a course may view themselves as less capable in that domain and that gender differences in grade penalties may be a useful measure of gender inequity in the classroom.ResultsIn this study, we examined grade penalties of 2445 students majoring in biological science or closely related fields across many commonly taken courses, many of which were mandatory. We find that on average, students received grade penalties in the 12 most commonly taken science courses for biosciences students at our institution. We also find that women had more extreme grade penalties than men in seven of the 12 science classes we investigated.ConclusionsThe pattern of grade penalties found in this study across a range of courses may result in long-term consequences for students’ STEM self-concept. Furthermore, women’s decisions to pursue STEM careers may be affected more by the grade penalty received in required science courses than men’s at least partly, because their grade penalties are often larger. Finally, the grade penalty measure can be easily computed by institutions concerned with equity.
A measurement system toward to skill analysis of wall painting using a roller brush
Authors: Miyairi Kyosuke , Takase Yutaka , Watanabe Yoshiaki , Miyaguchi Mikita , Yamazaki Kimitoshi 
Published: February 2023

AbstractIn this study, we describe a measurement system aiming to skill analysis of wall painting work using a roller brush. Our proposed measurement system mainly comprises an RGB-D sensor and a roller brush with sensors attached. To achieve our requirements in understanding roller operation, we developed an algorithm that is suitable to estimate the roller part pose with high accuracy. We also show a method to generate a swept map that can be used for both visualization and evaluation. In the proof experiment, a dataset for actual painting work was collected using the proposed measurement system. Then, the dataset was analyzed, and the quality of the work was quantitatively evaluated by comparing skilled and unskilled persons.
Negotiated belonging in sub-state nationalist contexts: young adult migrant narratives in Scotland and South Tyrol
Authors: Carlà Andrea , Nicolson Marcus 
Published: February 2023

AbstractThis contribution investigates the intersection between macro-level political narratives on diversity and micro-level lived experience of social inclusion and everyday interaction. The case studies for analysis comprise of two regional sub-state nationalist contexts, Scotland and South Tyrol, Italy. Scotland is a nation state that defines itself vis-a-vis the rest of the UK and where a discourse has emerged that Scottish nationalism is both civic and inclusive. South Tyrol is an autonomous province in northern Italy which remains a liminal space between Austria and Italy and is presented as a model to protect minorities. We argue for developing a critical stance on diversity narratives identified in these two-regions. Based on in-depth narrative interviews with young adult migrants, we use an ontological security framework to examine the relationship between macro-narratives and micro-level lived experiences of everyday social interactions. Firstly, we address how macro-level national identity discourses manifest themselves in micro-level everyday interactions. Secondly, we look at how young adults interpret these narratives when retelling their everyday experiences, sometimes to the point of excluding their own experiences of discrimination. In this way, we trace the negotiation of belongingness in these two contexts.
Rethinking place-based gender relations in the new country: the case of tertiary level Syrian students in Istanbul
Authors: Karameşe Şeyma 
Published: February 2023

AbstractThis paper analyses the dynamic interactions between space and identity by focusing on Syrian students in Turkey. It specifically asks how their migration experiences differentially affect their place-based identities and relationships. I use an intersectional approach and add dimensions of space, time, and everydayness to capture the relationship between the agents (Syrian youth) and the structure (norms, values, and institutions). Drawing on participant observation and in-depth interviews with 30 men and women Syrian students in Istanbul, I show how Syrian students negotiate interactions in the public space, working life, and gender roles, as well as their sense of freedom in the new context. Nevertheless, the migration process does not create the same results for both genders, and expecting a total transformation is not realistic. Women are more eager to adapt themselves to change when they are compared to men respondents. Space-based organizational culture in the daily life of Istanbul contributes to this main difference. In this regard, with sociological imagination, this article draws attention to the role of geography, which in its essence examines temporality and spatiality, and which has been underestimated in migration studies.
Anesthetic management of a patient with methamphetamine-associated pulmonary arterial hypertension undergoing laparoscopic cholecystectomy
Authors: Oshita Kensuke , Tokuyama Shin , Jotaki Shosaburo , Yokomizo Michiko , Hiraki Teruyuki 
Published: February 2023

Abstract
Background
Methamphetamine abuse is a serious public health concern and causes various life-threatening disorders including pulmonary arterial hypertension (PAH). Herein, we present the first case report describing the anesthetic management of a patient with methamphetamine-associated PAH (M-A PAH) undergoing laparoscopic cholecystectomy.

Case presentation
A 34-year-old female with M-A PAH suffered from deterioration of right ventricular (RV) heart failure due to recurrent cholecystitis and was scheduled for laparoscopic cholecystectomy. Preoperative assessment of PA pressure showed 82/32 (mean, 50) mmHg, and transthoracic echocardiology revealed a slight reduction of RV function. General anesthesia was induced and maintained by thiopental, remifentanil, sevoflurane, and rocuronium. PA pressure gradually increased after peritoneal insufflation; therefore, we administered dobutamine and nitroglycerin to decrease pulmonary vascular resistance (PVR). The patient emerged from anesthesia smoothly.

Conclusions
Avoiding increased PVR by appropriate anesthesia and medical hemodynamic support is an important consideration for patients with M-A PAH.
Regime-dependent drivers of the EUR/CHF exchange rate
Authors: Kotlarz Piotr , Hanke Michael , Stöckl Sebastian 
Published: February 2023

AbstractWe analyze drivers of the EUR/CHF exchange rate in different regimes between 2000 and 2020. Structural breaks between these subperiods are estimated in an integrated way together with the drivers that are relevant during these subperiods. Overall, the main drivers of the exchange rate include European equity and volatility indices, interest rate and term structure slope differentials, as well as monetary policy interventions. For the “peg period” September 2011–January 2015, in addition to the observed exchange rate we also analyze the drivers of the latent exchange rate that could have been observed in the absence of the peg. Interestingly, the SNB’s foreign currency investments became a significant driver of the EUR/CHF exchange rate only after the end of the peg period when there was no longer an officially communicated target rate.