bluuebunny/crossref_metadata_2025_split huggingface dataset:
Findings From the Step Up, Test Up Study of an Electronic Screening and Brief Intervention for Alcohol Misuse in Adolescents and Young Adults Presenting for HIV Testing: Randomized Controlled Efficacy Trial
Authors: Karnik Niranjan S , Kuhns Lisa M , Hotton Anna L , Del Vecchio Natascha , McNulty Moira , Schneider John , Donenberg Geri , Keglovitz Baker Kristin , Diskin Rose , Muldoon Abigail , Rivera Juan , Summersett Williams Faith , Garofalo Robert 
Published: March 2023

Background
Substance use, particularly binge drinking of alcohol and noninjection substance use, is associated with increased risk for HIV infection among youth, but structured substance use screening and brief intervention are not often provided as part of HIV risk reduction.

Objective
The purpose of the study was to test the efficacy of a fully automated electronic screening and brief intervention, called Step Up, Test Up, to reduce alcohol misuse among adolescents and young adults presenting for HIV testing. Secondary objectives were reduction in sexual risk and uptake of pre-exposure prophylaxis (PrEP) for HIV prevention.

Methods
Youth aged 16 years to 25 years who presented for HIV testing at community-based locations were recruited for study participation. Those who screened at moderate to high risk on the Alcohol Use Disorders Identification Test were randomized (1:1) to either an electronic brief intervention or a time-attention control. The primary outcome was change in alcohol use at 1, 3, 6, and 12-month follow-ups. Negative binomial and log binomial regression analyses with generalized estimating equations were conducted to evaluate the intervention efficacy.

Results
Among a sample of 329 youth, there were no significant differences in alcohol use outcomes between conditions over time or at the 1, 3, 6, or 12-month time points. In terms of secondary outcomes, there was evidence of reduction in condomless insertive anal sex under the influence of alcohol and drugs at 12 months compared with 3 months in the intervention versus the attention control condition (incidence rate ratio=0.15, 95% CI 0.05-0.44); however, there were no other significant differences in sexual risk and no difference in PrEP engagement.

Conclusions
We found no effect of electronic brief intervention to reduce alcohol use and some effect on sexual risk among youth aged 16 years to 25 years who present for HIV testing.

Trial Registration
ClinicalTrials.gov number NCT02703116; https://clinicaltrials.gov/ct2/show/NCT02703116

International Registered Report Identifier (IRRID)
RR2-10.1186/s12889-020-8154-6
The Impacts of a Psychoeducational Alcohol Resource During Internet-Delivered Cognitive Behavioral Therapy for Depression and Anxiety: Observational Study
Authors: Peynenburg Vanessa , Sapkota Ram P , Lozinski Tristen , Sundström Christopher , Wilhelms Andrew , Titov Nickolai , Dear Blake , Hadjistavropoulos Heather 
Published: March 2023

Background
Problematic alcohol use is common among clients seeking transdiagnostic internet-delivered cognitive behavioral therapy (ICBT) for depression or anxiety but is not often addressed in these treatment programs. The benefits of offering clients a psychoeducational resource focused on alcohol use during ICBT for depression or anxiety are unknown.

Objective
This observational study aimed to elucidate the impacts of addressing comorbid alcohol use in ICBT for depression and anxiety.

Methods
All patients (N=1333) who started an 8-week transdiagnostic ICBT course for depression and anxiety received access to a resource containing information, worksheets, and strategies for reducing alcohol use, including psychoeducation, reasons for change, identifying risk situations, goal setting, replacing drinking with positive activities, and information on relapse prevention. We assessed clients’ use and perceptions of the resource; client characteristics associated with reviewing the resource; and whether reviewing the resource was associated with decreases in clients’ alcohol use, depression, and anxiety at posttreatment and 3-month follow-up among clients dichotomized into low-risk and hazardous drinking categories based on pretreatment Alcohol Use Disorders Identification Test (AUDIT) scores.

Results
During the 8-week course, 10.8% (144/1333) of clients reviewed the resource, and those who reviewed the resource provided positive feedback (eg, 127/144, 88.2% of resource reviewers found it worth their time). Furthermore, 18.15% (242/1333) of clients exhibited hazardous drinking, with 14.9% (36/242) of these clients reviewing the resources. Compared with nonreviewers, resource reviewers were typically older (P=.004) and separated, divorced, or widowed (P<.001). Reviewers also consumed more weekly drinks (P<.001), scored higher on the AUDIT (P<.001), and were more likely to exhibit hazardous drinking (P<.001). Regardless of their drinking level (ie, low risk vs hazardous), all clients showed a reduction in AUDIT-Consumption scores (P=.004), depression (P<.001), and anxiety (P<.001) over time; in contrast, there was no change in clients’ drinks per week over time (P=.81). Reviewing alcohol resources did not predict changes in AUDIT-Consumption scores or drinks per week.

Conclusions
Overall, ICBT appeared to be associated with a reduction in alcohol consumption scores, but this reduction was not greater among alcohol resource reviewers. Although there was some evidence that the resource was more likely to be used by clients with greater alcohol-related difficulties, the results suggest that further attention should be given to ensuring that those who could benefit from the resource review it to adequately assess the benefits of the resource.
Relative anchorage loss under reciprocal anchorage in mandibular premolar extraction cases treated with clear aligners
Authors: Tang Zhenxing , Chen Weichang , Mei Li , Abdulghani Ehab A. , Zhao Zhihe , Li Yu 
Published: March 2023

ABSTRACT

Objectives
To compare mandibular relative anchorage loss (RAL) under reciprocal anchorage between first and second premolar extraction cases in bimaxillary protrusion mild crowding cases treated using clear aligner therapy (CAT).

Materials and Methods
Adult patients who met the following criteria were included: treated using CAT with bilateral mandibular premolar extractions and space closure using intra-arch reciprocal anchorage. RAL was defined as the percent molar mesial movement relative to the sum of molar mesial plus canine distal movement. Movements of the mandibular central incisor (L1), canine (L3), and first molar (L6) were measured based on superimposition of the pre- and post-treatment dentition and jaw models.

Results
Among the 60 mandibular extraction quadrants, 38 had lower first premolar (L4) and 22 had lower second premolar (L5) extracted. L6 mesial movement was 2.01 ± 1.11 mm with RAL of 25% in the L4 extraction group vs 3.25 ± 1.19 mm with RAL of 40% in the L5 extraction group (P &lt; .001). Tooth movement efficacy was 43% for L1 occlusogingival movement, 75% for L1 buccolingual inclination, 60% for L3 occlusogingival movement, and 53% for L3 mesiodistal angulation. L1 had unwanted extrusion and lingual crown torquing whereas L3 had unwanted extrusion and distal crown tipping, on which the power ridges or attachments had little preventive effect.

Conclusions
The average mandibular reciprocal RAL is 25% or 40% for extraction of L4 or L5, respectively, in CAT cases. A RAL-based treatment planning workflow is proposed for CAT extraction cases.
Penyuluhan Pencegahan Stunting Sejak Dini Bersama Mahasiswa KKN-T Universitas Alma Ata Yogyakarta
Authors: Azizah Dewi 
Published: March 2023

Stunting is one of the nutritional problems as well as a serious threat to children in Indonesia. Currently, the stunting rate in Indonesia is 37.2% or equivalent to 8 million children with suboptimal growth[3]. This is behind our need to hold a stunting counseling program, especially in pringgading hamlet, Guwosari district, Pajangan District, Bantul Regency. The form of counseling is in the form of providing information services by collaborating with local posyandu cadres to convey information to the community to invite the community to carry out public health movements. The hope is that the holding of stunting counseling activities in pringgading hamlet can increase public awareness regarding the importance of child growth and development so that increasingly noticed and increasing, so as to prevent stunting and reduce the percentage of stunting in Indonesia, especially in pringgading hamlet, Guwosari District, Pajangan District, Bantul Regency
Keywords: Student, Counseling, Stunting
Franczyza jako źródło finansowania działalności
Authors: Rychel Dominika , Skorża Monika , Zimoląg Monika 
Published: March 2023

Franczyza z roku na rok staje się coraz bardziej powszechną formą prowadzenia działalności i dostarczania produktów i usług. W wielu branżach taki sposób prowadzenia działalności staje się coraz bardziej popularny. Na przykład w branży gastronomicznej wiele przedsiębiorstw to marki należące do sieci franczyzowych, np. McDonald, czy KFC. W opracowaniu przedstawiono główne założenia tej formy dystrybucji, rodzaje franczyzy, jej zalety i wady, metody jej finansowania oraz liczby przedstawiające ilość marek franczyzowych w Polsce na przestrzeni lat.
Evaluation of effects on hepatocellular carcinoma cell line of Cocos nucifera: In vitro study
Authors: Tasdan Zeynep , Avci Gülçin Alp , Avci Emre 
Published: March 2023

Abstract

Objective: Cancer is one of the most important diseases today. The use of chemical drugs, surgical operations, and transplants is very common in its treatment. In addition to these treatment methods, studies include the effects of natural and plant-derived substances. Various substances are used in these studies, which are called phytotherapy. The antioxidant activity and cytotoxic effects of Cocos nucifera on hepatocellular carcinoma HepG-2 and the mouse fibroblast L929 cell line were investigated in this study.

Methods: In this study, in vitro cytotoxic effects of C. nucifera at different concentrations (7.81-500 mg/ml) were investigated on the L929 Mouse Fibroblast cell line and HepG-2 Hepatocellular Carcinoma cell line. In addition to these studies, their antioxidant capacity was evaluated via spectrophotometric methods. In this work, different concentrations of C. nucifera were examined.

Results: According to the results, C. nucifera had a cytotoxic effect in HepG-2 and ensured the proliferative effect of cells in the L929 cell line. Among C. nucifera extracts according to total antioxidant capacity results, C. nucifera extract was found to be the richest in antioxidants with 2.79 mmol/L, while the material with the lowest antioxidant capacity was determined to be C. nucifera milk. DPPH free radical scavenging activity results show the opposite.

Conclusion: In line with the data we obtained, it is thought that C. nucifera can be used in liver cancer studies, and its antioxidant effect may play an important role in balancing against oxidative stress. Simultaneously, the data show that the exposure time and concentrations of the active substance are related to the cytotoxic effect. However, it may be considered that the use of C. nucifera water, extract, and milk in cancer patients may be supported by more comprehensive clinical studies.
Comparison of two different file systems on postoperative pain after root canal instrumentation: A randomized controlled trial
Authors: Shahnawaz Saad , Shahroz Nabiya , Zafar Muhammad Ahmed , Sajjad Shahroz , Pasha Mehwish , Hussain Arfa Sabir 
Published: March 2023

Abstract

Introduction: In this study post instrumentation pain is evaluated between rotary hyflex CM files and conventional k-files at different time intervals.

Methodology: fifty patients were equally assigned into two groups and instrumented using hyflex cm or conventional files. VAS for pain was noted before the start of a root canal and after the procedure at 12, 24, and 48 hours.

Results: There was no significant difference at 12, 24, and 48 hours with P values being 0.127, 0.867, and 0.846 respectively.

Conclusion: There is no significant difference in causing post-instrumentation pain between hyflex CM and conventional files at different time intervals. However, when accessing preop pain of the conventional file group, it had more pain mean score compared to hyflex group. According to this study, Conventional files may be able to slightly decrease the chances of post-instrumentation pain more than hyflex CM instrumentation.
Management of denture stomatitis: An overview
Authors: Navabi Nader , Shakibaei Parham , Hassani Alireza Ranjbar 
Published: March 2023

Abstract
Denture stomatitis is a common inflammation of the palatal mucosa beneath removable dentures. The objective of this article was to examine the systematic reviews and clinical trials pertaining to the treatment of denture stomatitis. For this research, electronic databases (PubMed, Embase, Scopus, and ISI Web of Science) were searched from January 2000 to June 2021 using specified MESH keywords. Irrelevant articles were eliminated in three steps based on their titles, abstracts, and body texts. In the final analysis, 47 papers were selected, which included 12 systematic reviews and 35 clinical trials. Herbal compounds and denture disinfection were the interventions most commonly indicated. We concluded that, possibly due to the complex nature of this lesion’s etiology, there is no present definitive therapy guideline for this prevalent lesion.
Blood biomarkers predicting adverse clinical outcomes in congenital heart disease patients, with consideration for pulmonary valve replacement
Authors: Kainlauri Milla Marika , Kosovski Irina-Bianca 
Published: March 2023

Abstract

Objective: This review aims to make a brief overview of blood biomarkers’ clinical decision limits, possibly aiding in outcome prediction in all-aged Tetralogy of Fallot patients. Potentially, these biomarkers could also assist in necessity and timing of pulmonary valve replacement.

Methods: Studies with all-aged patients with Tetralogy or Pentalogy of Fallot and blood biomarkers, BNP, NT-proBNP and hs-cTn, usage in clinical outcome prediction were included. Additionally, pulmonary valve replacement indications were considered. Other congenital heart diseases, biomarkers irrelevant to clinical outcome and associated pathologies or physiological status were the exclusion criteria. Keywords, Tetralogy and Pentalogy of Fallot, pulmonary valve replacement, blood biomarkers, yielded 69 suitable studies from Google Scholar, PubMed and Web-of-Science. 30 studies were selected.

Results: Blood biomarkers were increased in TOF patients in comparison to controls; the higher the values, the worse adverse outcomes. Blood biomarkers combined with other biomarkers, imagistic methods or parameters showed promising results in outcome prediction.

Conclusions: Blood biomarkers are validated as follow-up predictors in congenital heart disease paediatric patients. Further research is required to establish age-appropriate clinical decision limits. Pulmonary valve replacement timing remains controversial.
Oral cancer chemoprevention: A review
Authors: Sujir Nanditha , Priyanka G , Ahmed Junaid , Saha Anindita , Chhaparwal Yogesh , Shenoy Nandita 
Published: March 2023

Abstract
Oral cancer is increasing in prevalence and its treatment is associated with high degree of morbidity and mortality. Thus, prevention of oral cancer is of utmost importance. Chemoprevention is the use of natural, synthetic, or biologic compounds to halt, reverse, or prevent the initial phases of carcinogenesis or the progression of neoplastic cells to cancer. This modality has been extensively researched in the last two decades for the prevention of oral cancer with the emergence of new information. Retinoids were the first chemopreventive agents to be tested in clinical settings. Since then, a number of new agents such as COX2 inhibitors, EGFR inhibitors, p53 targeted agents, thiazolidinediones and several natural agents have shown promise in oral cancer prevention. Chemopreventive trials in oral cancer tend to be long term studies and are thus challenging. This review article looks into the clinical evidence for the application of chemopreventive agents in clinical settings and also highlights the recent trends in oral cancer chemopreventive trials.
Clinical characteristics and endoscopic findings in autoimmune gastritis – A retrospective study
Authors: Gabos Gabriella , Nădășan Valentin , Nădășan Iris , Petruț Mădălina , Bernatchi Ioana , Bălășescu Mădălin , Nicolau Carmen 
Published: March 2023

Abstract

Objectives: Autoimmune gastritis (AG) is a rare condition that increases the risk of developing stomach adenocarcinomas or carcinoid tumours. The objectives of the present research were to summarise the clinical traits of AG patients, together with gastroscopic and histopatho-logic findings, demographic data, and hematologic characteristics.

Patients and methods: A medical centre assessed 58 AG patients from January 2019 to December 2022.

Results: The majority of the patients were female (73.7%), and the mean age of the participants at the time of the diagnosis was 57.7 ± 12.1 years. We identified pernicious anaemia (54.4%), iron deficiency anaemia (21.1%), as well as autoimmune disorders (96.5%). Though 78.9% of patients reported having gastrointestinal symptoms, 69% presented exclusively upper gastrointestinal symptoms, 17% only had lower, and 14% had concurrent upper and lower gastrointestinal symptoms. All 58 AG patients were examined for associated gastric lesions, although abnormal injuries were detected in only 22 of them. One patient (1.8%) had adenocarcinoma, while five patients (8.8%) had type 1 neuroendocrine tumours (NET). In addition, hyperplastic polyps were found in 16 (28.1%) individuals.

Conclusions: Other autoimmune diseases were present with AG, which showed a female predominance. Clinicians should give AG more significant thought by allowing access to interdisciplinary teams.
Opuntia fragilis (Nutt.) Haw. (Cactaceae) in the Bulgarian flora
Authors: Zahariev Dimcho 
Published: March 2023

Abstract
Opuntia fragilis (Nutt.) Haw. (Cactaceae) is the smallest and most cold-hardy species of genus Opuntia in North America. In Bulgaria it is grown as an ornamental plant, but in 2019 a population of this species was discovered by other researchers in natural habitats in Lozenska Mt (Western Bulgaria) at 630–660 m a.s.l. on an area (extent of occurrence) of ca. 100 m2. In July 2020, we established a population of this species on the Black Sea coast near the town of Primorsko (Eastern Bulgaria) at 5 m a.s.l. on an area of ca. 300 m2. The distance between the two populations is 360 km in a straight line and their origins are independent of each other. The two localities of this species are so far the only ones described not only for the territory of Bulgaria, but also for Europe.
Data are given on the conditions characterizing each of the localities. The possible reasons for the appearance in natural habitats of this alien plant species for the Bulgarian flora are considered. The impacts and threats this species may have on biodiversity in natural habitats are indicated. Measures have been proposed to control the populations of the species.
Tourism in Varna Black sea area – current situation and prospects for development
Authors: Sabrieva Sevdzhan 
Published: March 2023

Abstract
Tourism is one of the fastest growing industries of the new millennium. Bulgaria is a destination with an extremely large variety of natural and anthropogenic tourism resources and a relatively well-developed tourism sector of the economy, which brings significant income to the country’s economy. Varna tourist region is one of the leaders in the development of tourism, both for sea vacations and specialized types of tourism. Despite the great potential of the country and the researched tourist areas in particular, there are a number of problems related to uneven tourist development, seasonality, deteriorated tourist infrastructure and the quality of the services offered. The purpose of this paper is to study the current state of tourism and the opportunities for its development in the region.
Community Involvement in Place-Making: Present Map Methodology
Authors: Zaleckis Kestutis , Vitkuviene Jurga , Jankauskaite-Jureviciene Laura , Grazuleviciute-Vileniske Indre , Karvelyte-Balbieriene Vilma 
Published: March 2023

Abstract
The aim this research was to develop and test the mapping methodology, that would be applicable in the process of community involvement into place-making process and would focus on functioning and usage of public spaces. The methodology is referred to a Present Map methodology and is structured as a one-day mapping workshop involving drawing from memory, fieldwork, identifying the locations in the geographical map, structuring of the collected information and entering data into interactive online Present Map. The application of the methodology in Sanciai historic district has demonstrated that this methodology allows both collecting the material about the people’s experiences in public spaces of the locality necessary for research and planning, as well as connecting community with the place and empowering it by providing the working tools for exploration and understanding of the place and platform for expression in a form of interactive online Present Map.
IT reliability as a source of sustainability for organisations operating during the COVID-19 pandemic
Authors: Tworek Katarzyna 
Published: March 2023

Abstract
The article aims to show that reliable IT support was crucial for the survival and sustainability of organisations during the COVID-19 pandemic. The article considers the negative effect of the crisis caused by the COVID-19 pandemic on the organisational sustainability of an organisation (i.e., organisational performance through employee job performance). It explores the role of IT reliability in mitigating such a negative effect. To verify the hypotheses, the empirical studies were performed during the COVID-19 crisis with 1160 organisations operating in Poland, Italy and the USA. The data were analysed using multiple linear regression models with mediators and moderators. The results confirmed that due to the ability to limit the severity of a crisis-induced negative effect on employee job performance (influencing organisational performance), IT reliability could be considered a mitigator for the negative effect of the COVID-19 crisis on the sustainability of organisations. The results indicate that IT reliability should be fostered among organisations operating during the COVID-19 pandemic to maintain sustainability.