bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative analysis of color characteristics for Yangjiabu New Year woodblock paintings based on color science and spectral imaging
Authors: Zhang Fuzheng 
Published: September 2023

AbstractThe intangible cultural heritage of Yangjiabu New Year woodblock paintings (YNYWPs) has numerous potential cultural, artistic, and economic values. The quantitative color characteristics of YNYWPs, which have always been disregarded, can offer evidence in support of their inheritance and conservation. Utilizing the principles and methods of color science and spectral imaging technology, the color characteristics, including spectral characteristics, colorimetric characteristics, and color combination regularity, were quantitatively investigated by measuring and capturing the representative works. The results show that the spectral reflectances of the seven colors (i.e., red, yellow, green, cyan, violet, black, and paper color) adopted in the selected paintings have no significant structured features and can be accurately described using the first six derived eigenvectors by principal component analysis. The Xuan paper and the yellow color have higher reflectance than the other five colors. Correspondingly, their Commission Internationale de l'Eclairage (CIE) 1964 XYZ stimulus values are also relatively high. The others cover a narrow range in the CIE XYZ system. When transformed into the CIELAB color space, the seven colors can be relatively uniformly distributed in the color space. With regards to the color combination regularity, red, yellow, and cyan tend to occupy a large area in the selected paintings. In contrast, the other colors, especially green, are not frequently used. The resulting data of the color combination regularity quantitatively verify the color combination knack that is transmitted by word of mouth from generation to generation.
OH Radical‐Induced Oxidation in Nucleosides and Nucleotides Unraveled by Tandem Mass Spectrometry and Infrared Multiple Photon Dissociation Spectroscopy
Authors: Jiang Yining , Clavaguéra Carine , Indrajith Suvasthika , Houée‐Levin Chantal , Berden Giel , Oomens Jos , Scuderi Debora 
Published: September 2023

AbstractOH⋅‐induced oxidation products of DNA nucleosides and nucleotides have been structurally characterized by collision‐induced dissociation tandem mass spectrometry (CID‐MS2) and Infrared Multiple Photon Dissociation (IRMPD) spectroscopy. CID‐MS2 results have shown that the addition of one oxygen atom occurs on the nucleobase moiety. The gas‐phase geometries of +16 mass increment products of 2’‐deoxyadenosine (dA(O)H+), 2’‐deoxyadenosine 5’‐monophosphate (dAMP(O)H+), 2’‐deoxycytidine (dC(O)H+), and 2’‐deoxycytidine 5’‐monophosphate (dCMP(O)H+) are extensively investigated by IRMPD spectroscopy and quantum‐chemical calculations. We show that a carbonyl group is formed at the C8 position after oxidation of 2’‐deoxyadenosine and its monophosphate derivative. For 2’‐deoxycytidine and its monophosphate derivative, the oxygen atom is added to the C5 position to form a C−OH group. IRMPD spectroscopy has been employed for the first time to provide direct structural information on oxidative lesions in DNA model systems.
Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta‐analysis
Authors: Fasoulas Athanasios , Keratiotis Georgios , Spineli Loukia , Pandis Nikos , De Bruyne Mieke A. A. , De Moor Roeland J.G. , Meire Maarten A. 
Published: September 2023

AbstractObjectivesDifferent materials have been used for capping the pulp after exposure during caries removal in permanent teeth. The purpose of this study was to collate and analyze all pertinent evidence from randomized controlled trials (RCTs) on different materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth.Materials and MethodsTrials comparing two or more capping agents used for direct pulp capping (DPC) or pulpotomy were considered eligible. An electronic search of four databases and two clinical trial registries was carried out up to February 28, 2021 using a search strategy properly adapted to the PICO framework. Screening, data extraction, and risk of bias (RoB) assessment of primary studies were performed in duplicate and independently. The primary outcome was clinical and radiological success; secondary outcomes included continued root formation, tooth discoloration, and dentin bridge formation.Results21 RCTs were included in the study. The RoB assessment indicated a moderate risk among the studies. Due to significant clinical and statistical heterogeneity among the studies, performing network meta‐analysis (NMA) was not possible. An ad hoc subgroup analysis revealed strong evidence of a higher success of DPC with Mineral Trioxide Aggregate (MTA) compared to calcium hydroxide (CH) (odds ratio [OR] = 3.10, 95% confidence interval [CI]: 1.66−5.79). MTA performed better than CH in pulp capping (both DPC and pulpotomy) of mature compared to immature teeth (OR = 3.34, 95% CI: 1.81−6.17). The GRADE assessment revealed moderate strength of evidence for DPC and mature teeth, and low to very low strength of evidence for the remaining subgroups.ConclusionsConsiderable clinical and statistical heterogeneity among the trials did not allow NMA. The ad hoc subgroup analysis indicated that the clinical and radiographic success of MTA was higher than that of CH but only in mature teeth and DPC cases where the strength of evidence was moderate. PROSPERO Registration: number CRD42020127239.
Performance evaluation of five‐level packed U‐cell inverter and its fault‐tolerant variants
Authors: Rehman Haroon , Fahad Mohammad , Sarwar Adil , Tariq Mohd , Lin Chang‐Hua 
Published: September 2023

SummaryIn the power electronics industry, reliability is of utmost importance to manufacturers. Power semiconductor devices are extensively utilized in multilevel inverters (MLIs), which results in increased failure probability. MLI structures have a significant impact on the system's overall reliability. MLIs with a high degree of reliability reduce system maintenance costs and improve efficiency and the life of the entire system. This paper presents a comprehensive evaluation of five‐level packed U‐cell (PUC5) inverter, modified five‐level PUC (MPUC5) inverter, and their fault‐tolerant (FT) variants with respect to reliability, degree of fault tolerance, power loss and efficiency, and cost. A more accurate reliability evaluation method is used in this work in which failure rates of each component of inverter topologies under healthy and post‐fault conditions are calculated. Hence, this method provides more accurate reliability function of an MLI topology as compared to other methods in which failure rates are assumed to be same for all switches. Typhoon HIL‐402 emulator is used to demonstrate the FT capabilities of topologies in hardware‐in‐the‐loop (HIL) environments.
Controller parameters design of a fractional‐order LCL‐type grid‐connected inverter
Authors: Jiang Yuanhuai , Wang Xiaogang 
Published: September 2023

SummaryThe grid‐connected inverter (GCI) based on the fractional‐order LCL (FOLCL) filter can achieve good attenuation of resonant peak and simplify the control system design by omitting the capacitor current feedback as long as the orders of the inductor and capacitor are set appropriately. This paper investigates the parameter design methods of four types of controllers based on a single‐phase FOLCL‐type GCI without capacitor current feedback; the four controllers are the integer‐order proportional integral controller, fractional‐order proportional integral controller, integer‐order proportional resonance controller, and fractional‐order proportional resonance controller. Closed‐loop constraints based on steady‐state error, phase margin, and gain margin are given to design the specific parameters of each controller. The methods can accurately and quickly obtain the appropriate controller parameters to meet the system performance requirements without repeated trial and error. Simulations and hardware‐in‐the‐loop experiments verify the validity of the theoretical analyses.
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma
Authors: Liu Jia , Zhou Wei‐Yi , Luo Xiao‐Jing , Chen Yan‐Xing , Wong Chau‐Wei , Liu Ze‐Xian , Bo Zheng Jia‐ , Yu Mo Hai‐ , Chen Jun‐Quan , Li Jia‐Jun , Zhong Ming , Xu Yu‐Hong , Zhang Qi‐Hua , Pu Heng‐Ying , Wu Qi‐Nian , Jin Ying , Wang Zi‐Xian , Xu Rui‐Hua , Luo Hui‐Yan 
Published: September 2023

AbstractBackgroundPredictive biomarkers for oesophageal squamous cell carcinoma (ESCC) immunotherapy are lacking, and immunotherapy resistance remains to be addressed. The role of long noncoding RNA (lncRNA) in ESCC immune escape and immunotherapy resistance remains to be elucidated.MethodsThe tumour‐associated macrophage‐upregulated lncRNAs and the exosomal lncRNAs highly expressed in ESCC immunotherapy nonresponders were identified by lncRNA sequencing and polymerase chain reaction assays. CRISPR‐Cas9 was used to explore the functional roles of the lncRNA. RNA pull‐down, MS2‐tagged RNA affinity purification (MS2‐TRAP) and RNA‐binding protein immunoprecipitation (RIP) were performed to identify lncRNA‐associated proteins and related mechanisms. In vivo, the humanized PBMC (hu‐PBMC) mouse model was established to assess the therapeutic responses of specific lncRNA inhibitors and their combination with programmed cell death protein 1 (PD‐1) monoclonal antibody (mAb). Single‐cell sequencing, flow cytometry, and multiplex fluorescent immunohistochemistry were used to analyze immune cells infiltrating the tumour microenvironment.ResultsWe identified a lncRNA that is involved in tumour immune evasion and immunotherapy resistance. High LINC02096 (RIME) expression in plasma exosomes correlates with a reduced response to PD‐1 mAb treatment and poor prognosis. Mechanistically, RIME binds to mixed lineage leukaemia protein‐1 (MLL1) and prevents ankyrin repeat and SOCS box containing 2 (ASB2)‐mediated MLL1 ubiquitination, improving the stability of MLL1. RIME‐MLL1 increases H3K4me3 levels in the promoter regions of programmed death‐ligand 1 (PD‐L1) and indoleamine 2,3‐dioxygenase 1 (IDO‐1), constitutively increasing the expression of PD‐L1/IDO‐1 in tumour cells and inhibiting CD8+ T cells infiltration and activation. RIME depletion in huPBMC‐NOG mice significantly represses tumour development and improves the effectiveness of PD‐1 mAb treatment by activating T‐cell‐mediated antitumour immunity.ConclusionsThis study reveals that the RIME‐MLL1‐H3K4me3 axis plays a critical role in tumour immunosuppression. Moreover, RIME appears to be a potential prognostic biomarker for immunotherapy and developing drugs that target RIME may be a new therapeutic strategy that overcomes immunotherapy resistance and benefits patients with ESCC.
Phenotypic plasticity and genetic diversity shed light on endemism of rare Boechera perstellata and its potential vulnerability to climate warming
Authors: Boyd Jennifer Nagel , Baskauf Carol , Lindsey Annie , Anderson Jill T. , Brzyski Jessica , Cruse‐Sanders Jennifer 
Published: September 2023

AbstractThe rapid pace of contemporary environmental change puts many species at risk, especially rare species constrained by limited capacity to adapt or migrate due to low genetic diversity and/or fitness. But the ability to acclimate can provide another way to persist through change. We compared the capacity of rare Boechera perstellata (Braun's rockcress) and widespread B. laevigata to acclimate to change. We investigated the phenotypic plasticity of growth, biomass allocation, and leaf morphology of individuals of B. perstellata and B. laevigata propagated from seed collected from several populations throughout their ranges in a growth chamber experiment to assess their capacity to acclimate. Concurrently, we assessed the genetic diversity of sampled populations using 17 microsatellite loci to assess evolutionary potential. Plasticity was limited in both rare B. perstellata and widespread B. laevigata, but differences in the plasticity of root traits between species suggest that B. perstellata may have less capacity to acclimate to change. In contrast to its widespread congener, B. perstellata exhibited no plasticity in response to temperature and weaker plastic responses to water availability. As expected, B. perstellata also had lower levels of observed heterozygosity than B. laevigata at the species level, but population‐level trends in diversity measures were inconsistent due to high heterogeneity among B. laevigata populations. Overall, the ability of phenotypic plasticity to broadly explain the rarity of B. perstellata versus commonness of B. laevigata is limited. However, some contextual aspects of our plasticity findings compared with its relatively low genetic variability may shed light on the narrow range and habitat associations of B. perstellata and suggest its vulnerability to climate warming due to acclimatory and evolutionary constraints.
PopEquus: A predictive modeling tool to support management decisions for free‐roaming horse populations
Authors: Folt Brian , Schoenecker Kathryn A. , Ekernas L. Stefan , Edmunds David R. , Hannon Mark 
Published: September 2023

AbstractFeral horse (Equus caballus) population management is a challenging problem around the world because populations often exhibit density‐independent growth, can exert negative ecological effects on ecosystems, and require great cost to be managed. However, strong value‐based connections between people and horses cause contention around management decisions. To help make informed decisions, natural resource managers might benefit from more detailed understanding of how horse management alternatives, including combinations of removals and fertility control methods, could achieve objectives of sustainable, multiple‐use ecosystems while minimizing overall horse handling and fiscal costs. Here, we describe a modeling tool that simulates horse management alternatives and estimates trade‐offs in predicted metrics related to population size, animal handling, and direct costs of management. The model considers six management actions for populations (removals for adoption or long‐term holding; fertility control treatment with three vaccines, intrauterine devices, and mare sterilization), used alone or in combination. We simulated 19 alternative management scenarios at 2‐, 3‐, and 4‐year management return intervals and identified efficiency frontiers among alternatives for trade‐offs between predicted population size and six management metrics. Our analysis identified multiple alternatives that could maintain populations within target population size ranges, but some alternatives (e.g., removal and mare sterilization, removal and GonaCon treatment) performed better at minimizing overall animal handling requirements and management costs. Cost savings increased under alternatives with more effective, longer lasting fertility control techniques over longer management intervals compared with alternatives with less‐effective, shorter lasting fertility control techniques. We built a user‐friendly website application, PopEquus, that decision makers and interested individuals can use to simulate management alternatives and evaluate trade‐offs among management and cost metrics. Our results and website application provide quantitative trade‐off tools for horse population management decisions and can help support value‐based management decisions for wild or feral horse populations and ecosystems at local and regional scales around the world.
The kinocardiograph for assessment of fluid status in patients with acute decompensated heart failure
Authors: Herkert Cyrille , De Lathauwer Ignace , van Leunen Mayke , Spee Rudolph Ferdinand , Balali Paniz , Migeotte Pierre‐Francois , Hossein Amin , Lu Yuan , Kemps Hareld Marijn Clemens 
Published: September 2023

AbstractAimsTo improve telemonitoring strategies in heart failure patients, there is a need for novel non‐obtrusive sensors that monitor parameters closely related to intracardiac filling pressures. This proof‐of‐concept study aims to evaluate the responsiveness of cardiac kinetic energy (KE) measured with the Kinocardiograph (KCG), consisting of a seismocardiographic (SCG) sensor and a ballistocardiographic (BCG) sensor, during treatment of patients with acute decompensated heart failure.Methods and resultsEleven patients with acute decompensated heart failure who were hospitalized for treatment with intravenous diuretics received daily KCG measurements. The KCG measurements were compared with the diameter of the inferior vena cava (IVC) and body weight. Follow‐up stopped at discharge, that is, in the recompensated state. Median (interquartile range) weight and IVC diameter decreased significantly after diuretic treatment [weight 74.5 (67.6–98.7) to 73.3 (66.7–95.6) kg, P = 0.003; IVC diameter 2.47 (2.33–2.99) to 1.78 (1.65–2.47) cm, P = 0.03]. In contrast with BCG measurements, significant changes in median KE measured with SCG were observed during the passive filling phase of the diastole [SGG: 0.48 (0.39–0.60) to 0.69 (0.56–0.84), P = 0.026; BCG: 0.68 (0.46–0.73) to 0.68 (0.59–0.82), P = 0.062], the active filling phase of the diastole [SCG: 0.38 (0.30–0.61) to 0.31 (0.09–0.47), P = 0.016; BCG: 0.29 (0.17–0.39) to 0.26 (0.20–0.34), P = 0.248], and the ratio between the passive and active filling phases [SCG: 2.76 (1.68–5.30) to 5.02 (3.13–10.17), P = 0.006; BCG: 5.87 (3.57–7.55) to 5.27 (3.95–9.43), P = 0.790]. The correlations between changes in KE during the passive and active filling phases, using SCG, and changes in weight or IVC were non‐significant. Systolic KE did not show significant changes.ConclusionKE measured with the KCG using SCG is highly responsive to changes in fluid status. Future research is needed to confirm its accuracy in a larger study population and specifically its application for detection of clinical deterioration in the home‐environment.
Major adverse kidney events predict reduced survival in ventricular assist device supported patients
Authors: Barua Sumita , Conte Sean M. , Cherrett Callum , Kearney Katherine L. , Robson Desiree , Bragg Christopher , Macdonald Peter S. , Muthiah Kavitha , Hayward Christopher S. 
Published: September 2023

AbstractAimsThere is limited data describing major adverse kidney events (MAKE) in patients supported with ventricular assist devices (VAD). We aim to describe the association between MAKE and survival, risk factors for MAKE, and renal trajectory in VAD supported patients.Methods and resultsWe conducted a single‐centre retrospective analysis of consecutive VAD implants between 2010 and 2019. Baseline demographics, biochemistry, and adverse events were collected for the duration of VAD support. MAKE was defined as the first event to occur of sustained drop (>50%) in estimated glomerular filtration rate (eGFR), progression to stage V chronic kidney disease, initiation or continuation of renal replacement therapy beyond implant admission or death on renal replacement therapy at any time. One‐hundred and seventy‐three patients were included, median age 56.8 years, 18.5% female, INTERMACS profile 1 or 2 in 75.1%. Thirty‐seven patients experienced MAKE. On multivariate analysis, post‐implant clinical right ventricular failure and the presence of chronic haemolysis, defined by the presence of schistocytes on blood film analysis, were significantly associated with increased risk of MAKE (adjusted odds ratio 9.88, P < 0.001 and adjusted odds ratio 3.33, P = 0.006, respectively). MAKE was associated with reduced survival (hazard ratio 4.80, P < 0.001). Patients who died or experienced MAKE did not demonstrate the expected transient 3‐month improvement in eGFR, seen in other cohorts.ConclusionsMAKE significantly impacts survival. In our cohort, MAKE was predicted by post‐implant right ventricular failure and chronic haemolysis. The lack of early eGFR improvement on VAD support may indicate higher risk for MAKE.
Early steps in the biogenesis of mitochondrially encoded oxidative phosphorylation subunits
Authors: Jung Sung‐jun , Sridhara Sagar , Ott Martin 
Published: September 2023

AbstractThe complexes mediating oxidative phosphorylation (OXPHOS) in the inner mitochondrial membrane consist of proteins encoded in the nuclear or the mitochondrial DNA. The mitochondrially encoded membrane proteins (mito‐MPs) represent the catalytic core of these complexes and follow complicated pathways for biogenesis. Owing to their overall hydrophobicity, mito‐MPs are co‐translationally inserted into the inner membrane by the Oxa1 insertase. After insertion, OXPHOS biogenesis factors mediate the assembly of mito‐MPs into complexes and participate in the regulation of mitochondrial translation, while protein quality control factors recognize and degrade faulty or excess proteins. This review summarizes the current understanding of these early steps occurring during the assembly of mito‐MPs by concentrating on results obtained in the model organism baker's yeast.
Symbolic Regression of Upstream, Stormwater, and Tributary E. Coli Concentrations Using River Flows
Authors: Jagupilla Sarath Chandra K. , Vaccari David A. , Miskewitz Robert , Su Tsan‐Liang , Hires Richard I. 
Published: September 2023

ABSTRACT: Symbolic regression was used to model E. coli concentrations of upstream boundary, tributaries, and stormwater in the lower Passaic River at Paterson, New Jersey. These models were used to simulate boundary concentrations for a water quality analysis simulation program to model the river. River flows from upstream and downstream boundaries of the study area were used as predictors. The symbolic regression technique developed a variety of candidate models to choose from due to multiple transformations and model structures considered. The resulting models had advantages such as better goodness‐of‐fit statistics, reasonable bounds to outputs, and smooth behavior. The major disadvantages of the technique are model complexity, difficulty to interpret, and overfitting. The Nash–Sutcliffe efficiencies of the models ranged from 0.61 to 0.88, and they adequately captured the upstream boundary, tributary, and stormwater concentrations. The results suggest symbolic regression can have significant applications in the areas of hydrologic, hydrodynamic, and water quality modeling.
Narrow and wide replication of Chalfin and McCrary (REStat, 2018)
Authors: Crudu Federico , Moharir Advait 
Published: September 2023

SummaryWe undertake a narrow and wide replication of "Are US Cities Underpoliced? Theory and Evidence" by Chalfin and McCrary. Using data from medium to large cities in the United States from 1960 to 2010, the authors estimate the effect of police on crime. To correct for the presence of measurement error, they propose to combine the information from two proxies of the police variable within the generalized method of moments framework. Throughout our replication exercise, we find that, in general, the original results are robust to computation in R compared to STATA and to the inclusion of more recent data (until 2019).