bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence in marketing research and future research directions: Science mapping and research clustering using bibliometric analysis
Authors: Thakur Jyoti , Kushwaha Bijay Prasad 
Published: September 2023

AbstractThe marketing environment has experienced significant advancements due to the transformative influence of technologies such as artificial intelligence, data analytics, decision sciences, and robotics. These innovations have entirely reshaped the fundamental marketing principles as we know them. This study uses bibliometric analysis to conduct a systematic literature review of research on Artificial Intelligence (AI) in marketing and provides future research directions. It also aims to identify the most influential and productive contributors and progression of research on AI in marketing. The bibliographic data of 317 documents on artificial intelligence in marketing research was extracted from the Scopus database. The bibliometric analysis is performed to comprehensively understand the most influential and productive articles, authors, sources, and the top contributing countries and institutions towards the discipline of AI in marketing research. The results and the publication trend show exponential growth yearly in AI in marketing research. Furthermore, it discovered four main thematic clusters: Data mining and deep learning in decision support systems, big data and generative AI in marketing, AI‐enabled commerce, and chatbots and marketing Tech that represent the recent research being carried out under AI in marketing. The trending topics recognized are marketing algorithms for decision‐making, AI‐enabled marketing, the Internet of Things (IoT) and marketing, natural language processing and customer service, robotic services, and chatbots. This study also emphasizes potential future research areas, building upon the established thematic clusters.
Assessment of refeeding syndrome definitions and 30‐day mortality in critically ill adults: A comparison study
Authors: Naik Nimish Manoj , Li Jianhua , Seres David , Freedberg Daniel E. 
Published: September 2023

AbstractBackgroundPatients in the intensive care unit (ICU) are at high risk for refeeding syndrome (RFS), yet there is uncertainty regarding how RFS should be operationalized in the ICU. We evaluated different definitions for RFS and tested how they associated with patient‐centered outcomes in the ICU.MethodsThis was a retrospective comparison study. Patients age ≥18 years were eligible if they were newly initiated on enteral feeding while hospitalized in the ICU. Eight definitions for RFS were operationalized, including that from the American Society for Parenteral and Enteral Nutrition (ASPEN), all based on electrolyte levels from immediately before until up to 5 days after the initiation of enteral nutrition. Patients were followed for death or for ICU‐free days, a measure of healthcare utilization.ResultsIn all, 2123 patients were identified, including 406 (19.1%) who died within 30 days of ICU admission and 1717 (80.9%) who did not. Prevalence of RFS varied from 1.5% to 88% (ASPEN definition) depending on the RFS definition used. The excess risk for death associated with RFS varied from 33% to 92% across definitions. The development of RFS based on the ASPEN definition was associated with a greater decrease in ICU‐free days compared with other definitions, but the relationship was not statistically significant.ConclusionEight definitions for RFS were evaluated, none of which showed strong associations with death or ICU‐free days. It may be challenging to achieve a standardized definition for RFS that is based on electrolyte values and predicts mortality or ICU‐free days.
Identification of novel antioxidant collagen peptides for preventing and treating H2O2‐induced oxidative stress in HepG2 cells through in vitro and in silico approaches
Authors: Du Bowei , Zhang Chao , Deng Guiya , Zhang Shuai , Wang Shiqi , Guan Yuepeng , Huang Yaqin 
Published: September 2023

AbstractBACKGROUNDNowadays, the prevalence of oxidative stress‐related chronic diseases is increasing. The identification of novel antioxidant collagen peptides to counteract oxidative stress for individuals' health has gained significant attention.RESULTSIn this study, collagen peptides with antioxidant activities were separated and identified by ion chromatography, reversed‐phase high‐performance liquid chromatography and liquid chromatography–tandem mass spectrometry. The identified antioxidant collagen peptides were further screened by molecular docking for Keap1‐targeted peptide inhibitors and their theoretical interaction mechanisms were investigated. Four novel antioxidant collagen peptides, GPAGPIGPVG, GPAGPpGPIG, ISGPpGPpGPA and IDGRPGPIGPA, with high binding affinity to Keap1 were selected. Molecular docking results demonstrated that the putative antioxidant mechanism of the four antioxidant collagen peptides contributed to their blockage of Keap1–Nrf2 interactions. The results of antioxidant activity of the four antioxidant collagen peptides proved that IDGRPGPIGPA exerted a high scavenging capacity for DPPH and ABTS free radicals, while GPAGPpGPIG improved the resistance of cells to hydrogen peroxide‐induced oxidative damage by promoting the activation of intracellular antioxidant enzymes and the production of reduced glutathione in human hepatoma (HepG2) cells.CONCLUSIONThe antioxidant collagen peptides (GPAGPIGPVG, GPAGPpGPIG, ISGPpGPpGPA and IDGRPGPIGPA) will be developed as novel functional food for human health in the near future. © 2023 Society of Chemical Industry.
Atopic dermatitis, systemic inflammation and subsequent dementia risk
Authors: Vingeliene Snieguole , Hiyoshi Ayako , Carlberg Michael , Garcia‐Argibay Miguel , Lentjes Marleen , Fall Katja , von Kobyletzki Laura , Montgomery Scott 
Published: September 2023

AbstractBackgroundAtopic dermatitis is a chronic inflammatory skin disease and inflammation has been implicated in development of other chronic diseases, but few studies have examined the relationship with dementia.ObjectivesThis study examines associations of atopic dermatitis (AD) and systemic inflammation in adolescence measured using erythrocyte sedimentation rate (ESR), as well as AD diagnosed in adulthood, with dementia risk.MethodsWe used three Swedish register‐based cohorts. Cohort I (N = 795,680) comprised men, born in 1951–1968, who participated in the military conscription examinations with physician‐assessed AD and ESR; Cohort II (N = 1,757,600) included men and women, born in 1951–1968; and Cohort III (N = 3,988,783) included all individuals in Sweden, born in 1930–1968. We used Cox regression, estimating hazard ratios (HR), with the follow‐up from 50 years of age to dementia diagnosis, date of emigration, death, or 31 December 2018, whichever occurred first. Further, we used a sibling comparison design to adjust for unmeasured confounders shared among siblings.ResultsCohort I: 1466 dementia events were accrued during follow‐up of 7.8 years, with a crude rate of 21.6 [95% confidence interval (CI): 20.6, 22.8] per 100,000 person‐years. Cohort II: 3549 dementia events were accrued during follow‐up of 7.4 years, with a crude rate of 23.7 (95% CI: 22.9, 24.5) per 100,000 person‐years. Cohort III: 120,303 dementia events were accrued during follow‐up of 23.7 years, with a crude rate of 180.3 (95% CI: 179.3, 181.3) per 100,000 person‐years. In multivariable analysis using Cohort I, there was no association between AD and dementia [HR 0.68 (95% CI 0.32, 1.43)], nor with moderate [HR 0.71 (95% CI: 0.46, 1.10)] or high [HR 1.23 (95% CI: 0.87, 1.75)] ESR. AD was not associated with dementia risk in Cohort II [HR 1.28 (0.97, 1.71)] or Cohort III [HR 1.01 (0.92, 1.11)].ConclusionsAD was not associated with dementia risk, neither was systemic inflammation measured by ESR in adolescence.
Psoriasis on both saphenectomized lower limbs: Bilateral Brodell syndrome
Authors: Ruocco Eleonora 
Published: September 2023

AbstractA 52‐year‐old woman presented with typical patches of psoriasis restricted to the lower limbs that had been saphenectomized 16 years before. Saphenectomy uniformly destroys the cellophane‐like walls of the major lymphatic vessel running adjacent to the saphenous vein, thus creating an obstacle to the local lymph drainage and changes in local immune response. The involved immunocompromised district may be more susceptible to develop immune‐related disorders.
Students bridging the diversity gap in dermatology—A mixed methods study of medical education
Authors: Salihu Shihan , Hart Harmony , Wort Christopher , Reza Musarrat M. 
Published: September 2023

AbstractBackgroundAfter noticing a lack of diversity in pictures for skin conditions and dermatology teaching, seven medical students applied for funding from the University of Exeter to design a project with the aim of expanding their dermatology knowledge through developing diverse teaching resources and assessing knowledge using innovative evaluation methods. Students then tested their project by raising awareness about common skin conditions and their presentation on different skin colours to the public in Exeter.ObjectivesThis paper aims to reflect on and evaluate the experience of medical students in developing and implementing this project, with a focus on the significant positive impact it had on their dermatological knowledge and practical ability to assess skin conditions on diverse skin tones.MethodsEach team member was asked to complete a survey to self‐assess critical skills before and after participating in the project and write a post‐event reflective piece. The responses to the survey and reflective pieces were further analysed for specific themes.ResultsAll members perceived a significant improvement in three common themes: (i) bridging the knowledge gap, (ii) gaining confidence in designing innovative resources and (iii) enhancing communication skills. The survey and reflective pieces also identified areas of improvement in the project.ConclusionsBeyond expanding the dermatology knowledge of medical students, the project encouraged critical thinking and proactiveness as future clinicians. Medical students perceived improvements in key skills such as effective communication, public speaking and developing innovative teaching resources. Medical schools must create opportunities to enable such student‐led projects and embed inclusion and diversity in the medical curriculum so that future clinicians are well‐equipped to serve a rapidly diversifying population. This project has now received further funding and is being expanded to create a digital resource pack for all medical school educators and students.
Bioinspired Multiscale Mineralization: From Fundamentals to Potential Applications
Authors: Zuo Liangrui , Yang Yifei , Zhang Hongbo , Ma Zhengxin , Xin Qiangwei , Ding Chunmei , Li Jianshu 
Published: September 2023

AbstractThe wondrous and imaginative designs of nature have always been an inexhaustible treasure trove for material scientists. Throughout the long evolutionary process, biominerals with hierarchical structures possess some specific advantages such as outstanding mechanical properties, biological functions, and sensing performances, the formation of which (biomineralization) is delicately regulated by organic component. Provoked by the subtle structures and profound principles of nature, bioinspired functional minerals can be designed with the participation of organic molecules. Because of the designable morphology and functions, multiscale mineralization has attracted more and more attention in the areas of medicine, chemistry, biology, and material science. This review provides a summary of current advancements in this extending topic. The mechanisms underlying mineralization is first concisely elucidated. Next, several types of minerals are categorized according to their structural characteristic, as well as the different potential applications of these materials. At last, a comprehensive overview of future developments for bioinspired multiscale mineralization is given. Concentrating on the mechanism of fabrication and broad application prospects of multiscale mineralization, the hope is to provide inspirations for the design of other functional materials.
Validity of Single Fluorescent Molecule to Report Local Dynamics of a Polymer Matrix: The Effect of Molecular Architecture
Authors: Zhu Hanqi , Li Haipeng , Zhang Hao , Yang Jingfa , Yan Shouke , Zhao Jiang 
Published: September 2023

AbstractThe influence of van der Waals volume as well as molecular configuration of the probe on its rotation is investigated by defocused single molecule fluorescence microscopy. The results show that the probe with a larger van der Waals volume has lower integrated power spectra density and the fraction of rotational molecules at each temperature. However, the asymmetric configuration of probe can make the integrated power spectra density and the fraction of rotational molecules larger. Therefore, the van der Waals volume of probe is the most dominating factor to determine the length scales and frequency of reported local dynamics while the asymmetric configuration of probe can bring about additional effect.
Machine Learning‐Aided Prediction and Construction of a Descriptor for Polymer Properties: A Case Study on the Lower Critical Solution Temperature of Copolymerized N‐Isopropylacrylamides
Authors: Sugawara Yuuki 
Published: September 2023

AbstractArtificial Intelligence (AI) technology has been increasingly applied in the field of chemistry in recent years. For proof of concept for the application of AI technology to polymer research, a state‐of‐the‐art machine learning (ML) technique is employed to systematically elucidate the lower critical solution temperature (LCST) of N‐isopropylacrylamide (NIPAAm) copolymers using data collected from the literature. The information on 110 NIPAAm random copolymers is collected to extract their LCSTs and the chemical and physical parameters of the copolymers and comonomers. The ML analysis reveals that the copolymerized ratio, the elemental composition of carbon and oxygen in the comonomers, and the water solubility of the comonomers are crucial parameters affecting the LCST, and the constructed ML model successfully predicts the LCSTs of various NIPAAm copolymers. Furthermore, the genetic algorithm using symbolic regression identifies a simple and comprehensive descriptor for the LCST. This study demonstrates the usefulness of data‐driven ML techniques for polymer research with the rapid and accurate prediction of polymer properties.
Novel Polyetherimide Dielectrics: Molecular Design, Energy Storage Property, and Self‐Healing Performance
Authors: Cao Shimo , Tong Hui , Wang Silin , Liu Junbiao 
Published: September 2023

AbstractThe development of high‐temperature resistant dielectrics with excellent dielectric properties and self‐healing behavior is crucial for the application of metallized film capacitors. In this work, a series of polyetherimide (PEI) dielectric films are designed and fabricated. The introduction of polar groups is in favor to the increase of permittivity, and the flexible connection such as the ether group will facilitate the reduction of dielectric loss. Moreover, the oxygen elements are beneficial to the “self‐healing” of metallized film capacitors. Consequently, the permittivity of 3.53–4.00, dissipation factor of 0.281–0.517%, and Weibull breakdown strength of 347–674 MV m−1 are obtained for the PEI dielectrics. In addition, PEI‐4 (BPADA‐BAPP) and PEI‐8 (BPADA‐MDA) are selected to further investigate dielectric breakdown (150 °C), electrical displacement‐electric filed (D‐E) loop (at room temperature and 150 °C) as well as self‐healing performance, which will evaluate their potential in practical applications. The results show that PEI‐8 has stable breakdown field strength and high charge–discharge efficiency at elevated temperatures. Metallized film capacitor based on PEI‐8 exhibits excellent self‐healing performance, with pleasing self‐clear morphology, high breakdown voltage, and reduced self‐healing energy. Therefore, PEI‐8 is considered as a potential candidate for metallized film capacitors applied under harsh conditions.
A Sensitive Concentration‐ and Polarity‐Dependent Pyrene‐Derived Vibrationally Resolved Fluorescence Probe for The Polymer Interdiffusion Study
Authors: Mo Ruibin , Zhang Fusheng , Sheng Xinxin , Zhang Xinya 
Published: September 2023

AbstractThe vibrationally resolved pyrene fluorescence probe method is once popular but now languished, because the vibrationally resolved patterns of pyrene with limited sensitivity and concentration independence have not been updated for over 50 years. During investigation on the polymer interdiffusion of a latex film, it is found that a pyrene acylhydrazone whose vibrationally resolved fluorescence pattern contradictory to those reported in pyrene and most pyrene derivatives. The pyrene acylhydrazone has sensitive concentration‐ and polarity‐dependent fluorescence spectra (the sensitivity on polarity is at most 26 times higher than the old vibrationally resolved patterns), and the sensitivity well remains when it is copolymerized in a polymer. The vibrationally resolved spectrum of this pyrene acylhydrazone is a powerful fluorescence probe, which would be as useful as the pyrene excimer probe nowadays popular.
Prime editor‐mediated functional reshaping of ACE2 prevents the entry of multiple human coronaviruses, including SARS‐CoV‐2 variants
Authors: Zhao Wenwen , Li Jifang , Wang Xiao , Xu Wei , Gao Bao‐Qing , Xiang Jiangchao , Hou Yaofeng , Liu Wei , Wu Jing , Qi Qilian , Wei Jia , Yang Xiaoyu , Lu Lu , Yang Li , Chen Jia , Yang Bei 
Published: September 2023

AbstractThe spike protein of SARS‐CoV‐2 hijacks the host angiotensin converting enzyme 2 (ACE2) to meditate its entry and is the primary target for vaccine development. Nevertheless, SARS‐CoV‐2 keeps evolving and the latest Omicron subvariants BQ.1 and XBB have gained exceptional immune evasion potential through mutations in their spike proteins, leading to sharply reduced efficacy of current spike‐focused vaccines and therapeutics. Compared with the fast‐evolving spike protein, targeting host ACE2 offers an alternative antiviral strategy that is more resistant to viral evolution and can even provide broad prevention against SARS‐CoV and HCoV‐NL63. Here, we use prime editor (PE) to precisely edit ACE2 at structurally selected sites. We demonstrated that residue changes at Q24/D30/K31 and/or K353 of ACE2 could completely ablate the binding of tested viruses while maintaining its physiological role in host angiotensin II conversion. PE‐mediated ACE2 editing at these sites suppressed the entry of pseudotyped SARS‐CoV‐2 major variants of concern and even SARS‐CoV or HCoV‐NL63. Moreover, it significantly inhibited the replication of the Delta variant live virus. Our work investigated the unexplored application potential of prime editing in high‐risk infectious disease control and demonstrated that such gene editing‐based host factor reshaping strategy can provide broad‐spectrum antiviral activity and a high barrier to viral escape or resistance.
SEMA3B‐AS1 suppresses colorectal carcinoma progression by inhibiting Semaphorin 3B‐dependent VEGF signaling pathway activation
Authors: Wang Yi‐Qing , Chen Hui , Xu Shuang , Liao Cong‐Rui , Xu Anran , Han Yue , Yang Min‐Hui , Zhao Li , Hu Sha‐Sha , Wang Lan , Li Qing‐Yuan , Zhan Ling‐Ying , Ding Yan‐Qing , Wang Shuang 
Published: September 2023

AbstractMounting evidence has demonstrated the considerable regulatory effects of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of various carcinomas. LncRNA Semaphorin 3B (SEMA3B) antisense RNA 1 (SEMA3B‐AS1) has been found to be dysregulated in a few carcinomas recently. However, its potential function and mechanism in colorectal carcinoma (CRC) have not yet been examined. Here we show thatSEMA3B‐AS1acts as a crucial regulator of CRC progression. We found thatSEMA3B‐AS1expression was downregulated in CRC cell lines and tissues. Downregulation ofSEMA3B‐AS1was significantly associated with poor survival in CRC patients. Overexpression ofSEMA3B‐AS1reduced the cell growth and metastasis of CRC in vivo and in vitro. In addition,SEMA3B‐AS1promoted the expression of its sense‐cognate gene SEMA3B, a member of the Semaphorin family (SEMAs), by recruiting EP300 to induce H3K9 acetylation at the SEMA3B promoter. Furthermore, we proved thatSEMA3B‐AS1suppressed CRC angiogenesis by affecting the vascular endothelial growth factor signaling pathway activation which was regulated by the SEMA3B‐NRP1 axis. Our work unravels a novel mechanism ofSEMA3B‐AS1in the inhibition of CRC malignant progression and highlights its probability as a new promising diagnostic marker and therapeutic target for CRC interventions.
CT‐based radiomics prediction of CXCL13 expression in ovarian cancer
Authors: Xu Wenting , Zhu Chengyi , JI Dan , Qian Haiqing , Shi Lingli , Mao Xuping , Zhou Huifang , Wang Lihong 
Published: September 2023

AbstractBackgroundOvarian cancer, the most common malignancy in the female reproductive system, and patients tend to be at middle and advanced clinical stages when diagnosed. Therefore, early detection and early diagnosis have important clinical significance for the treatment of ovarian cancer patients. CXCL13, a chemokine with the ligands CXCR3 and CXCR5, is involved in the tumor metastasis process.PurposeThis study aimed to predict mRNA expression of CXCL13 in ovarian cancer tissues noninvasively.MethodsMedical imaging data and transcriptomic sequencing data of the 343 ovarian cancer patients were downloaded from the TCIA and TCGA databases, respectively. Seventy‐six radiomics features were extracted from the CT data. Seven features were selected for model construction by using logistic regression. Accuracy, specificity, sensitivity, positive predictive value, and negative predictive value were used to evaluate the radiomics model.ResultsHigh CXCL13 expression was found to be a significant protective factor for OS [HR (95% CI) = 0.755 (0.622–0.916),p = 0.004]. There was a significant positive correlation between CXCL13 and the degree of eosinophil infiltration. A calibration curve and the Hosmer‒Lemeshow goodness‐of‐fit test showed that the prediction probability of the radiomics prediction model for high expression of CXCL13 was consistent with the true value. The AUC value of the nomogram model's ability to predict OS (12 months) was 0.758. The calibration plot and DCA both showed high clinical applicability for the nomogram model.ConclusionCXCL13 is a candidate predictive biomarker for OC and correlates with the degree of plasma cell and eosinophil infiltration.