bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple regression method for working face mining pressure prediction based on hydraulic support monitoring dataset
Authors: Dong Jianjun , Xie Zhengquan , Jiang Hao , Gao Ke 
Published: February 2023

Introduction: In the coal mining process, the intense mining pressure is an important factor hindering the safe and efficient production of the working face. In severe cases, it causes deformations in roadways such as roof breakages and rockbursts, and leads to instability. This can result in the roof falling over a large area and the coal wall, thereby inducing dynamic disasters. These aspects have restricted the economic benefits of coal.Methods: In this study, we set four model limitations based on the limited scope of action of the mining pressure itself and the quantitative relationships between mining pressures in different regions. A multiple linear regression model with these limitations is proposed for predicting the mining pressure for preventing roof breakages and rockbursts. Based on a hydraulic support monitoring dataset from a fully mechanized caving face of coal mining, the mining pressure prediction model is trained by using the first 70% of the dataset. And the linear regression coefficient of the model and the predicted value of the mining pressure are obtained. Then, the last 30% of the dataset was used for the validation of the model.Results: The research results show that the constrained multiple linear regression model can achieve remarkable prediction results. According to predictions of tens of thousands of on-site mining pressure datasets, the predicted data and actual pressure data have the same change trend and maintain a low relative error.Discussion: Therefore, after real-time mining pressure monitoring, the system obtains the roof pressure of the fully mechanized mining face. According to the dataset, the proposed prediction model algorithm quickly predicts the roof pressure value of the next mining section and effectively forewarns roof breakages and other accidents.
Enhanced insulin activity achieved in VDRa/b ablation zebrafish
Authors: Liu Ruolan , Lu Yao , Peng Xuyan , Jia Jingyi , Ruan Yonglin , Shi Shengchi , Shu Tingting , Li Tianhui , Jin Xia , Zhai Gang , He Jiangyan , Lou Qiyong , Yin Zhan 
Published: February 2023

Introduction1α,25-dihydroxyvitamin D3 (1α,25[OH]2VD3) is a hormone known for its key roles in calcium absorption and nutrient metabolism. In teleost fishes, 1α,25(OH)2VD3 insufficiency causes impaired glucose metabolism and lipid oxidation. However, the cascade and mechanisms of 1α,25(OH)2VD3 and the vitamin d receptor (VDR) signaling are unclear.ResultsIn this study, two genes (vdra and vdrb) encoding paralogs of VDRs were genetically knocked out in zebrafish. Growth retardation and accumulated visceral adipose tissue have been observed in vdra-/-;vdrb-/- deficient line. In the liver elevated accumulation of triglycerides and suppressed lipid oxidation were detected. Morover significantly elevated 1α,25(OH)2VD3 levels were detected in vdra-/-;vdrb-/- zebrafish due to cyp24a1 transcription repression. Furthermore VDRs ablation Enhanced insulin signaling including elevated insulin/insra trancriptional levels, glycolysis, lipogenesis and promoted AKT/mTOR activity.DiscussionIn conclusion, our present studies provides a zebrafish model with an elevated 1α,25(OH)2VD3 levels in vivo. The 1α,25(OH)2VD3/VDRs signaling promote lipid oxidation activity. However 1α,25(OH)2VD3 activity of regulation of glucose homeostasis through Insulin/Insr was independent of nuclear VDRs in teleosts.
Diabetes management in patients undergoing total pancreatectomy: A single center cohort study
Authors: Zhao Tianyi , Fu Yong , Zhang Taiping , Guo Junchao , Liao Quan , Song Shuoning , Duo Yanbei , Gao Yuting , Yuan Tao , Zhao Weigang 
Published: February 2023

BackgroundTotal pancreatectomy (TP) has been increasingly performed in recent years. However, studies on diabetes management after TP during different postoperative periods are still limited.ObjectivesThis study aimed to evaluate the glycemic control and insulin therapy of patients undergoing TP during the perioperative and long-term follow-up period.MethodsNinety-three patients undergoing TP for diffuse pancreatic tumors from a single center in China were included. Based on preoperative glycemic status, patients were divided into three groups: nondiabetic group (NDG, n = 41), short-duration diabetic group (SDG, preoperative diabetes duration ≤12 months, n = 22), and long-duration diabetic group (LDG, preoperative diabetes duration &gt;12 months, n = 30). Perioperative and long-term follow-up data, including the survival rate, glycemic control, and insulin regimens, were evaluated. Comparative analysis with complete insulin-deficient type 1 diabetes mellitus (T1DM) was conducted.ResultsDuring hospitalization after TP, glucose values within the target (4.4-10.0 mmol/L) accounted for 43.3% of the total data, and 45.2% of the patients experienced hypoglycemic events. Patients received continuous intravenous insulin infusion during parenteral nutrition at a daily insulin dose of 1.20 ± 0.47 units/kg/day. In the long-term follow-up period, glycosylated hemoglobin A1c levels of 7.43 ± 0.76% in patients following TP, as well as time in range and coefficient of variation assessed by continuous glucose monitoring, were similar to those in patients with T1DM. However, patients after TP had lower daily insulin dose (0.49 ± 0.19 vs 0.65 ± 0.19 units/kg/day, P &lt; 0.001) and basal insulin percentage (39.4 ± 16.5 vs 43.9 ± 9.9%, P = 0.035) than patients with T1DM, so did those using insulin pump therapy. Whether in the perioperative or long-term follow-up period, daily insulin dose was significantly higher in LDG patients than in NDG and SDG patients.ConclusionsInsulin dose in patients undergoing TP varied according to different postoperative periods. During long-term follow-up, glycemic control and variability following TP were comparable to complete insulin-deficient T1DM but with fewer insulin needs. Preoperative glycemic status should be evaluated as it could guide insulin therapy after TP.
Exploring plastic transport dynamics in the Odaw river, Ghana
Authors: Pinto Rose Boahemaa , Barendse Tom , van Emmerik Tim , van der Ploeg Martine , Annor Frank Ohene , Duah Kwame , Udo Job , Uijlenhoet Remko 
Published: February 2023

Plastic pollution in rivers threatens ecosystems, increases flood risk due to its accumulations at hydraulic structures and its final emissions into the ocean threaten aquatic life, especially and probably most in coastal urbanized areas. Previous work suggests that plastic pollution in these urban rivers is influenced by hydrometeorological and anthropogenic factors. However, the transport dynamics of the plastics in such rivers are non-linear and complex and remain largely unresolved. Here, we show that tidal dynamics can be the main driver of plastic transport closest to the river mouth. Outside the tidal zone, rainfall and river discharge were identified to be more important drivers. We monitored plastic transport in the Odaw river, Ghana during the dry season. The Odaw drains the densely populated city of Accra and discharges into the Gulf of Guinea. Data were collected between March and May 2021 (dry season), using visual counting at four bridges along the river, of which two were located within the tidal zone. We explored the correlations between river plastic transport, and rainfall, tidal dynamics, and river discharge. Finally, we estimated the total plastic mass transport by using item-to-mass conversion data from previously published literature. We observed a peak in plastic transport at the upstream bridge within the tidal zone after an increase in rainfall (7.3 times larger). We found a gradient of the hydrometeorological factors driving plastic transport. Closer to the river mouth, tidal dynamics were more strongly correlated with plastic transport than upstream. The daily mass transport was estimated to be between 1.4–3.8 × 102 kg/d, which is lower than previous model estimates. These results add to the evidence of inconsistent correlations between plastic transport and hydrometeorological variables. Long-term monitoring data is required to further investigate this. The results also support the hypothesis that tidal dynamics are a crucial factor in controlling the emissions of plastics from rivers into the ocean. The findings provide a baseline for the Odaw river during the dry season and allow for comparison with the wet season. The approach adopted here also serves as a blueprint for similar urban river systems, regionally and globally.
Extensive set of African ancestry-informative markers (AIMs) to study ancestry and population health
Authors: Boudeau Samantha , Ramakodi Meganathan P. , Zhou Yan , Liu Jeffrey C. , Ragin Camille , Kulathinal Rob J. 
Published: February 2023

Introduction: Human populations are often highly structured due to differences in genetic ancestry among groups, posing difficulties in associating genes with diseases. Ancestry-informative markers (AIMs) aid in the detection of population stratification and provide an alternative approach to map population-specific alleles to disease. Here, we identify and characterize a novel set of African AIMs that separate populations of African ancestry from other global populations including those of European ancestry.Methods: Using data from the 1000 Genomes Project, highly informative SNP markers from five African subpopulations were selected based on estimates of informativeness (In) and compared against the European population to generate a final set of 46,737 African ancestry-informative markers (AIMs). The AIMs identified were validated using an independent set and functionally annotated using tools like SIFT, PolyPhen. They were also investigated for representation of commonly used SNP arrays.Results: This set of African AIMs effectively separates populations of African ancestry from other global populations and further identifies substructure between populations of African ancestry. When a subset of these AIMs was studied in an independent dataset, they differentiated people who self-identify as African American or Black from those who identify their ancestry as primarily European. Most of the AIMs were found to be in their intergenic and intronic regions with only 0.6% in the coding regions of the genome. Most of the commonly used SNP array investigated contained less than 10% of the AIMs.Discussion: While several functional annotations of both coding and non-coding African AIMs are supported by the literature and linked these high-frequency African alleles to diseases in African populations, more effort is needed to map genes to diseases in these genetically diverse subpopulations. The relative dearth of these African AIMs on current genotyping platforms (the array with the highest fraction, llumina’s Omni 5, harbors less than a quarter of AIMs), further demonstrates a greater need to better represent historically understudied populations.
Lipid metabolism-related gene signature predicts prognosis and depicts tumor microenvironment immune landscape in gliomas
Authors: Li Junhong , Zhang Shuxin , Chen Siliang , Yuan Yunbo , Zuo Mingrong , Li Tengfei , Wang Zhihao , Liu Yanhui 
Published: February 2023

BackgroundGlioma is the most common primary brain tumor in adults and accounts for more than 70% of brain malignancies. Lipids are crucial components of biological membranes and other structures in cells. Accumulating evidence has supported the role of lipid metabolism in reshaping the tumor immune microenvironment (TME). However, the relationship between the immune TME of glioma and lipid metabolism remain poorly described.Materials and methodsThe RNA-seq data and clinicopathological information of primary glioma patients were downloaded from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA). An independent RNA-seq dataset from the West China Hospital (WCH) also included in the study. Univariate Cox regression and LASSO Cox regression model was first to determine the prognostic gene signature from lipid metabolism-related genes (LMRGs). Then a risk score named LMRGs-related risk score (LRS) was established and patients were stratified into high and low risk groups according to LRS. The prognostic value of the LRS was further demonstrated by construction of a glioma risk nomogram. ESTIMATE and CIBERSORTx were used to depicted the TME immune landscape. Tumor Immune Dysfunction and Exclusion (TIDE) was utilized to predict the therapeutic response of immune checkpoint blockades (ICB) among glioma patients.ResultsA total of 144 LMRGs were differentially expressed between gliomas and brain tissue. Finally, 11 prognostic LMRGs were included in the construction of LRS. The LRS was demonstrated to be an independent prognostic predictor for glioma patients, and a nomogram consisting of the LRS, IDH mutational status, WHO grade, and radiotherapy showed a C-index of 0.852. LRS values were significantly associated with stromal score, immune score, and ESTIMATE score. CIBERSORTx indicated remarkable differences in the abundance of TME immune cells between patients with high and low LRS risk levels. Based on the results of TIDE algorithm, we speculated that the high-risk group had a greater chance of benefiting from immunotherapy.ConclusionThe risk model based upon LMRGs could effectively predict prognosis in patients with glioma. Risk score also divided glioma patients into different groups with distinct TME immune characteristics. Immunotherapy is potentially beneficial to glioma patients with certain lipid metabolism profiles.
The clinical value of neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) for predicting the occurrence and severity of pneumonia in patients with intracerebral hemorrhage
Authors: Wang Rui-Hong , Wen Wan-Xin , Jiang Ze-Ping , Du Zhen-Ping , Ma Zhao-Hui , Lu Ai-Li , Li Hui-Ping , Yuan Fang , Wu Shi-Biao , Guo Jian-Wen , Cai Ye-Feng , Huang Yan , Wang Li-Xin , Lu Hong-Ji 
Published: February 2023

BackgroundInflammatory mechanisms play important roles in intracerebral hemorrhage (ICH) and have been linked to the development of stroke-associated pneumonia (SAP). The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), platelet-to-lymphocyte ratio (PLR) and systemic inflammation response index (SIRI) are inflammatory indexes that influence systemic inflammatory responses after stroke. In this study, we aimed to compare the predictive value of the NLR, SII, SIRI and PLR for SAP in patients with ICH to determine their application potential in the early identification of the severity of pneumonia.MethodsPatients with ICH in four hospitals were prospectively enrolled. SAP was defined according to the modified Centers for Disease Control and Prevention criteria. Data on the NLR, SII, SIRI and PLR were collected at admission, and the correlation between these factors and the clinical pulmonary infection score (CPIS) was assessed through Spearman’s analysis.ResultsA total of 320 patients were enrolled in this study, among whom 126 (39.4%) developed SAP. The results of the receiver operating characteristic (ROC) analysis revealed that the NLR had the best predictive value for SAP (AUC: 0.748, 95% CI: 0.695-0.801), and this outcome remained significant after adjusting for other confounders in multivariable analysis (RR=1.090, 95% CI: 1.029-1.155). Among the four indexes, Spearman’s analysis showed that the NLR was the most highly correlated with the CPIS (r=0.537, 95% CI: 0.395-0.654). The NLR could effectively predict ICU admission (AUC: 0.732, 95% CI: 0.671-0.786), and this finding remained significant in the multivariable analysis (RR=1.049, 95% CI: 1.009-1.089, P=0.036). Nomograms were created to predict the probability of SAP occurrence and ICU admission. Furthermore, the NLR could predict a good outcome at discharge (AUC: 0.761, 95% CI: 0.707-0.8147).ConclusionsAmong the four indexes, the NLR was the best predictor for SAP occurrence and a poor outcome at discharge in ICH patients. It can therefore be used for the early identification of severe SAP and to predict ICU admission.
Positive faecal immunochemical test predicts the onset of inflammatory bowel disease: A nationwide, propensity score-matched study
Authors: Lee Eunyoung , Lee Gil Ho , Park Bumhee , Ahn Sung Soo , Noh Choong-Kyun 
Published: February 2023

Background &amp; aimsThe faecal immunochemical test (FIT), a non-invasive test for screening colorectal cancer (CRC), is being increasingly understood to reflect heightened inflammation. We aimed to investigate the association between abnormal FIT results and onset of inflammatory bowel disease (IBD), a disease characterized with chronic gut mucosal inflammation.MethodsParticipants in the Korean National Cancer Screening Program for CRC between 2009–2013 were analysed and divided into positive and negative FIT result groups. The incidence rates of IBD after screening were calculated after excluding cases of haemorrhoids, CRC, and IBD at baseline. Cox proportional hazard analyses were used to identify independent risk factors for IBD occurrence during follow-up, and 1:2 propensity score matching was performed as a sensitivity analysis.ResultsIn total, 229,594 and 815,361 participants were assigned to the positive and negative FIT result groups, respectively. The age- and sex-adjusted incidence rates of IBD in participants with positive and negative test results were 1.72 and 0.50 per 10,000 person-years, respectively. Adjusted Cox analysis revealed that FIT positivity was associated with a significantly higher risk of IBD (hazard ratio 2.93, 95% confidence interval: 2.46, 3.47, P &lt;.001), which was consistent for both disease subtypes of ulcerative colitis and Crohn’s disease. The results of Kaplan–Meier analysis in the matched population yielded identical findings.ConclusionsAbnormal FIT results could be a preceding sign of incident IBD in the general population. Those with positive FIT results and suspected IBD symptoms could benefit from regular screening for early disease detection.
The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury
Authors: Teoh Chia Wei , Riedl Khursigara Magdalena , Ortiz-Sandoval Carolina G. , Park Jee Woo , Li Jun , Bohorquez-Hernandez Arlette , Bruno Valentina , Bowen Emily E. , Freeman Spencer A. , Robinson Lisa A. , Licht Christoph 
Published: February 2023

BackgroundCalcineurin inhibitors (CNIs) are associated with nephrotoxicity, endothelial cell dysfunction, and thrombotic microangiopathy (TMA). Evolving evidence suggests an important role for complement dysregulation in the pathogenesis of CNI-induced TMA. However, the exact mechanism(s) of CNI-induced TMA remain(s) unknown.MethodsUsing blood outgrowth endothelial cells (BOECs) from healthy donors, we evaluated the effects of cyclosporine on endothelial cell integrity. Specifically, we determined complement activation (C3c and C9) and regulation (CD46, CD55, CD59, and complement factor H [CFH] deposition) as these occurred on the endothelial cell surface membrane and glycocalyx.ResultsWe found that exposing the endothelium to cyclosporine resulted in a dose- and time-dependent enhancement of complement deposition and cytotoxicity. We, therefore, employed flow cytometry, Western blotting/CFH cofactor assays, and immunofluorescence imaging to determine the expression of complement regulators and the functional activity and localization of CFH. Notably, while cyclosporine led to the upregulation of complement regulators CD46, CD55, and CD59 on the endothelial cell surface, it also diminished the endothelial cell glycocalyx through the shedding of heparan sulfate side chains. The weakened endothelial cell glycocalyx resulted in decreased CFH surface binding and surface cofactor activity.ConclusionOur findings confirm a role for complement in cyclosporine-induced endothelial injury and suggest that decreased glycocalyx density, induced by cyclosporine, is a mechanism that leads to complement alternative pathway dysregulation via decreased CFH surface binding and cofactor activity. This mechanism may apply to other secondary TMAs—in which a role for complement has so far not been recognized—and provide a potential therapeutic target and an important marker for patients on calcineurin inhibitors.
Effects of polysaccharides from Lyophyllum decastes (Fr.) Singer on gut microbiota via in vitro-simulated digestion and fermentation
Authors: Zhang Fangfang , Xiao Ying , Pan Liang , Yu Ling , Liu Yanfang , Li Deshun , Liu Xiaojie 
Published: February 2023

IntroductionLyophyllum decastes (Fr.) Singer polysaccharides (LDSPs) have been verified to possess strong biological properties. However, the effects of LDSPs on intestinal microbes and their metabolites have rarely been addressed.MethodsThe in vitro-simulated saliva-gastrointestinal digestion and human fecal fermentation were used to evaluate the effects of LDSPs on non-digestibility and intestinal microflora regulation in the present study.ResultsThe results showed a slight increase in the content of the reducing end of the polysaccharide chain and no obvious change in the molecular weight during in vitro digestion. After 24 h in vitro fermentation, LDSPs were degraded and utilized by human gut microbiota, and LDSPs could be transformed into short-chain fatty acids leading to significant (p &lt; 0.05) decrease in the pH of the fermentation solution. The digestion did not remarkably affect the overall structure of LDSPs and 16S rRNA analysis revealed distinct shifts in the gut microbial composition and community diversity of the LDSPs-treated cultures, compared with the control group. Notably, the LDSPs group directed a targeted promotion of the abundance of butyrogenic bacteria, including Blautia, Roseburia, and Bacteroides, and an increase in the n-butyrate level.DiscussionThese findings suggest that LDSPs might be a potential prebiotic to provide a health benefit.