bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hormonal crosstalk controls cell death induced by kinetin in roots of Vicia faba ssp. minor seedlings
Authors: Kaźmierczak Andrzej , Tarkowská Danuše , Plačková Lenka , Doniak Magdalena , Doležal Karel 
Published: July 2023

AbstractStudies of vitality/mortality of cortex cells, as well as of the concentrations of ethylene (ETH), gibberellins (GAs), indolic compounds/auxins (ICs/AUXs) and cytokinins (CKs), were undertaken to explain the hormonal background of kinetin (Kin)-regulated cell death (RCD), which is induced in the cortex of the apical parts of roots of faba bean (Vicia faba ssp. minor) seedlings. Quantification was carried out with fluorescence microscopy, ETH sensors, spectrophotometry and ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC‒MS/MS). The results indicated that Kin was metabolized to the transport form, i.e., kinetin-9-glucoside (Kin9G) and kinetin riboside (KinR). KinR was then converted to cis-zeatin (cZ) in apical parts of roots with meristems, to cis-zeatin riboside (cZR) in apical parts of roots without meristems and finally to cis-zeatin riboside 5’-monophosphate (cZR5’MP), which is indicated to be a ligand of cytokinin-dependent receptors inducing CD. The process may be enhanced by an increase in the amount of dihydrozeatin riboside (DHZR) as a byproduct of the pathway of zeatin metabolism. It seems that crosstalk of ETH, ICs/AUXs, GAs and CKs with the cZR5’MP, the cis-zeatin-dependent pathway, but not the trans-zeatin-dependent pathway, is responsible for Kin-RCD, indicating that the process is very specific and offers a useful model for studies of CD hallmarks in plants.
Xanthan biopolymer-based soil treatment effect on kaolinite clay fabric and structure using XRD analysis
Authors: Kwon Yeong-Man , Chang Ilhan , Cho Gye-Chun 
Published: July 2023

AbstractIn this study, we evaluated the impact of xanthan gum biopolymer (XG) on kaolinite fabrics using X-ray diffraction (XRD) and the ensuing changes in the compaction behavior and shear resistance of kaolinite soils. The XRD peak analysis revealed that XG changed kaolinite fabrics into face-to-face associations. Moreover, environmental scanning electron microscopy showed the formation of XG-bridges between kaolinite particles, resulting in the change in fabrics and subsequently improving the resistance of kaolinite to external forces. Consequently, as XG content increased, the maximum dry density decreased, and the undrained shear strength increased. The viscous XG hydrogels produced a higher optimal moisture content and increased resistance to shear force. This study showed that XG affects the mechanical properties of kaolinite through changing kaolinite fabrics (up to 0.5% of the XG-to-kaolinite mass ratio) and absorbing pore-fluids (excess XG over 0.5% of the XG-to-kaolinite mass ratio).
Establishing haptic texture attribute space and predicting haptic attributes from image features using 1D-CNN
Authors: Hassan Waseem , Joolee Joolekha Bibi , Jeon Seokhee 
Published: July 2023

AbstractThe current study strives to provide a haptic attribute space where texture surfaces are located based on their haptic attributes. The main aim of the haptic attribute space is to come up with a standardized model for representing and identifying haptic textures analogous to the RGB model for colors. To this end, a four dimensional haptic attribute space is established by conducting a psychophysical experiment where human participants rate 100 real-life texture surfaces according to their haptic attributes. The four dimensions of the haptic attribute space are rough-smooth, flat-bumpy, sticky-slippery, and hard-soft. The generalization and scalability of the haptic attribute space is achieved by training a 1D-CNN model for predicting attributes of haptic textures. The 1D-CNN is trained using the attribute data from psychophysical experiments and image features collected from the images of real textures. The prediction power granted by the 1D-CNN renders scalability to the haptic attribute space. The prediction accuracy of the proposed 1D-CNN model is compared against other machine learning and deep learning algorithms. The results show that the proposed method outperforms the other models on MAE and RMSE metrics.
Association between statin use and open-angle glaucoma: a nested case–control study using the Japanese claims database
Authors: Yokoyama Satoshi , Nakagawa Chihiro , Hosomi Kouichi 
Published: July 2023

AbstractThe association between statins and open-angle glaucoma (OAG) remains controversial. This study investigated the relationship between statins and OAG in Japanese patients with dyslipidemia using the Japanese administrative claims database. A nested case–control study using two models was conducted using the JMDC claims database (01/2005–01/2020). The onset of OAG: index date was defined as the diagnosis of glaucoma, prescription of anti-glaucoma drugs, or surgery of glaucoma. For each case, a maximum of 10 age-, sex-, and calendar year/month–matched controls were randomly selected by risk-set sampling with replacement. The number of statin prescriptions during the exposure assessment period, which was identified as the 12-month (model 1) or 24-month (model 2) periods prior to the index date, was used as an indicator for statin exposure. Adjusted odds ratios (aORs) and 95% confidence interval (CI) were estimated using conditional logistic regression analyses. We identified 375,373 patients with newly diagnosed dyslipidemia. Of these, 6180 cases and 61,792 controls (model 1) and 4153 cases and 41,522 controls (model 2) were selected. Statin use was not identified as a significant risk factor for OAG (model 1: aOR 0.98, 95% CI 0.93–1.03, model 2: aOR 0.97, 95% CI 0.91–1.04). Compared with nonexposure, short-term exposure (< 2 years) to statins was not related to an increased risk of OAG in the Japanese working-age population with dyslipidemia.
The differential mediating roles of resilience in the relationship between meaningful living and stress among college students during the COVID-19 pandemic
Authors: Al-Mahrouqi Tamadhir , Chan Moon Fai , Al-Mukhaini Maryam , Al Shehi Manar , Al-Huseini Salim , Jahan Firdous , Al Balushi Naser , Panchatcharam Sathiya M , Al Alawi Mohammed 
Published: July 2023

AbstractThe current literature, mostly Euro-American based, indicates that the presence of meaning in life (MIL) improves resilience and lowers stress. However, the differential mediating roles of resilience in the relationship between the search for and presence of MIL, and stress have not been explored. This study aimed to investigate the differential mediating roles of resilience in the relationship between the presence of and search for MIL, and stress among Omani college students amid the COVID-19 pandemic. This cross-sectional study consisted of the Brief Resilience Scale, Perceived Stress Scale 4, and Meaning in Life Questionnaire, as well as socio-demographic questions. A path analysis model was used to examine the hypothesis. A total of 970 Omani college students responded to the questionnaire. Findings indicate that searching for MIL was significantly associated with a high level of stress directly (β = 0.023; p < 0.001) and indirectly, through a negative effect on resilience (β =  0.006; p < 0.001). Conversely, the presence of MIL was significantly associated with a decreased level of stress directly (β = − 0.045; p < 0.001) and indirectly via a positive effect on resilience (β = − 0.151; p < 0.001). In keeping with the proposed hypothesis, this study contributes to the current knowledge, by extrapolating the effect of searching for MIL on resilience and stress, and culturally re-contextualizing MIL research. University counseling centers could adopt meaning-based strategies to mitigate stress by promoting meaningful living and resilience.
The Evolution of Genetic Testing from Focused Testing to Panel Testing and from Patient Focused to Population Testing: Are We There Yet?
Authors: Gima Lauren , Solomon Ilana , Hampel Heather 
Published: July 2023

AbstractThe field of cancer genetics has evolved significantly over the past 30 years. Genetic testing has become less expensive and more comprehensive which has changed practice patterns. It is no longer necessary to restrict testing to those with the highest likelihood of testing positive. In addition, we have learned that the criteria developed to determine who has the highest likelihood of testing positive are neither sensitive nor specific. As a result, the field is moving from testing only the highest risk patients identified based on testing criteria to testing all cancer patients. This requires new service delivery models where testing can be mainstreamed into oncology clinics and posttest genetic counseling can be provided to individuals who test positive and those with concerning personal or family histories who test negative. The use of videos, testing kiosks, chatbots, and genetic counseling assistants have been employed to help facilitate testing at a larger scale and have good patient uptake and satisfaction. While testing is important for cancer patients as it may impact their treatment, future cancer risks, and family member's cancer risks, it is unfortunate that their cancer could not be prevented in the first place. Population testing for all adults would be a strategy to identify individuals with adult-onset diseases before they develop cancer in an attempt to prevent it entirely. A few research studies (Healthy Nevada and MyCode) have offered population testing for the three Centers for Disease Control and Prevention Tier 1 conditions: hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia finding a prevalence of 1 in 70 individuals in the general population. We anticipate that testing for all cancer patients and the general population will continue to increase over the next 20 years and the genetics community needs to help lead the way to ensure this happens in a responsible manner.
On deconstructing mood
Authors: Radatz Hans-Ingo 
Published: July 2023

Abstract
The Spanish subjunctive has traditionally been
described by some linguists as an inflection expressing mood and by
others as a marker of subordination. In this contribution I will
argue that both functions can be observed, but that Spanish (and
Romance) subjunctives increasingly become associated with
subordination and lose their modal semantics in the process. I will
therefore claim that taking the subjunctive paradigm as a monolithic
category with one central semantic value is inadequate for
representing all the various constructions in which subjunctive
forms appear. As an alternative, I will suggest to model the various
Spanish subjunctive constructions within a construction grammar
framework informed by Traugott & Trousdale’s work on
constructionalisation. An abstract subjunctive schema is posited
from which a non-assertion, a modal agreement and a modal trigger
subschema are derived. Of these three, two are essentially
procedural with little to no semantic content, while only the
non-assertion schema partly corresponds semantically to the
traditional assertion vs. non-assertion analysis.
Microbiome convergence and deterministic community assembly along successional biocrust gradients on potash salt heaps
Authors: Ohan Juliette A , Siani Roberto , Kurth Julia K , Sommer Veronika , Glaser Karin , Karsten Ulf , Schloter Michael , Schulz Stefanie 
Published: July 2023

AbstractPotash mining, typically performed for agricultural fertilizer production, can create piles of residual salt waste that are ecologically detrimental and difficult to revegetate. Biological soil crusts (biocrusts) have been found growing on and around these heaps, suggesting resilience to the hypersaline environment. We set out to understand the community dynamics of biocrust formation by examining two succesionary salinity gradients at historical mining sites using a high throughput amplicon sequencing. Bare heaps were distinct, with little overlap between sites, and were characterized by high salinity, low nutrient availability, and specialized, low diversity microbial communities, dominated by Halobacteria, Chloroflexia, and Deinococci. ‘Initial’ stages of biocrust development were dominated by site-specific Cyanobacteria, with significant overlap between sites. Established biocrusts were the most diverse, with large proportions of Alphaproteobacteria, Anaerolineae, and Planctomycetacia. Along the salinity gradient at both sites, salinity decreased, pH decreased, and nutrients and Chlorophyll a increased. Microbiomes between sites converged during succession and community assembly process analysis revealed biocrusts at both sites were dominated by deterministic, niche-based processes; indicating a high degree of phylogenetic turnover. We posit early cyanobacterial colonization is essential for biocrust initiation, and facilitates later establishment of plant and other higher-level biota.
Current Landscape and Future Directions of Pediatric Transplant Infectious Diseases
Authors: Otto William R , Green Michael , Danziger-Isakov Lara 
Published: July 2023

Abstract
As the field of pediatric transplant infectious diseases continues to grow, new challenges are constantly arising. Advances in immunosuppressive drugs, antimicrobial development, and novel diagnostic tests add new wrinkles to the care of pediatric transplant recipients. This progress in clinical care serves as a call to direct energy toward pediatric transplant infectious diseases research, to better understand how to use these interventions in pediatric practice.
Teaching Observation as a Faculty Development Tool in Medical Education: A Scoping Review
Authors: Kitto Simon , Danilovich Natalia , Rowland Paula , Leslie Karen , Hendry Paul , Hodgson Amanda , Fantaye Arone , Lochnan Heather 
Published: July 2023

Introduction:
Health professions education often includes teaching observation to inform faculty development (FD) and indirectly improve student performance. Although these FD approaches are well received by faculty, they remain underused and/or underreported, with limited opportunities to receive feedback in workplace contexts. The goal of our study was to map the depth and breadth of education literature on the use of observation of teaching as a tool of professional development in medical education.

Methods:
Following the methodology by Arksey and O'Malley, we conducted a scoping review and searched four databases for articles published in English (final searches in April 2022).

Results:
Of 2080 articles identified, 45 met the inclusion criteria. All observation activities were associated with one of the following FD approaches: peer observation of teaching (23 articles, 51%), peer coaching (12, 27%), peer review (9, 20%), and the critical friends approach (1, 2%). Thirty-three articles (73%) concerned formative versions of the observation model that took place in clinical settings (21, 47%), and they tended to be a voluntary (27, 60%), one-off (18, 40%), in-person intervention (29, 65%), characterized by limited institutional support (13, 29%). Both barriers and challenges of teaching observation were identified.

Discussion:
This review identified several challenges and shortcomings associated with teaching observation, such as inadequate methodological quality of research articles, inconsistent terminology, and limited understanding of the factors that promote long-term sustainability within FD programs. Practical strategies to consider when designing an FD program that incorporates teaching observation are outlined.
Nonsclerotic Lichen Sclerosus: Definition of a Concept and Pathologic Description
Authors: Day Tania , Selim M. Angelica , Allbritton Jill I. , Scurry James ,   for the ISSVD Difficult Pathologic Diagnoses Committee (DPDC)
Published: July 2023

Objective
Nonsclerotic lichen sclerosus (NSLS) refers to the clinicopathologic situation of examination findings consistent with lichen sclerosus (LS) but without dermal sclerosis on microscopy. This review aims to describe the features of NSLS and provide a classification framework.

Methods
The International Society of the Study of Vulvovaginal Diseases tasked the Difficult Pathologic Diagnoses Committee with development of consensus documents for conditions with problematic histopathology. The Difficult Pathologic Diagnoses Committee reviewed the literature on NSLS and formulated descriptions and diagnostic criteria, then approved by the International Society of the Study of Vulvovaginal Diseases membership.

Results
Nonsclerotic LS may be categorized into 4 histopathologic subtypes: lichenoid dermatitis, hypertrophic lichenoid dermatitis, dermal fibrosis without acanthosis, and dermal fibrosis with acanthosis. Each has a pathologic differential diagnosis of 1 or more entities, so clinical correlation is required for final diagnosis of LS. There is no evidence to support a reliable association between absent sclerosis and clinical appearance, duration, or oncogenic potential of LS.

Conclusions
Pathologists and clinicians should be familiar with the concept of NSLS and its implications for patient management. Use of the term “early LS” to indicate a lack of sclerosis in presumed LS should be abandoned. Clinical correlation is required to confirm LS from among the differential diagnoses.
Exploring healthcare authorities’ decisions to sustain or abandon a management control initiative
Authors: Glenngård Anna H , Ellegård Lina Maria 
Published: July 2023

AbstractWe explore how a management control initiative travels across and is translated within organizations—from the decision motives for adoption or rejection to the subsequent decision motives for sustaining or abandoning the control—through the lens of diffusion theory. Our empirical case is the journey of activity‐based funding of hospitals across 21 Swedish healthcare authorities. We develop a framework in which the abandonment or sustainment of a management control is explained by the interplay between the decision motive underlying the adoption and the propensity to continuously adapt it in response to new organizational goals and circumstances. This propensity is determined by fits and misfits between organizational characteristics and properties of the control.
Retirement and cognitive aging in a racially diverse sample of older Americans
Authors: Andel Ross , Veal Britney M. , Howard Virginia J. , MacDonald Leslie A. , Judd Suzanne E. , Crowe Michael 
Published: July 2023

AbstractBackgroundRetirement represents a crucial transitional period for many adults with possible consequences for cognitive aging. We examined trajectories of cognitive change before and after retirement in Black and White adults.MethodsLongitudinal examination of up to 10 years (mean = 7.1 ± 2.2 years) using data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study–a national, longitudinal study of Black and White adults ≥45 years of age. Data were from 2226 members of the REGARDS study who retired around the time when an occupational ancillary survey was administered. Cognitive function was an average ofz‐scores for tests of verbal fluency, memory, and global function.ResultsCognitive functioning was stable before retirement (Estimate = 0.05,p = 0.322), followed by a significant decline after retirement (Estimate = −0.15,p < 0.001). The decline was particularly pronounced in White (Estimate = −0.19,p < 0.001) compared with Black (Estimate = −0.07,p = 0.077) participants, twice as large in men (Estimate = −0.20,p < 0.001) compared with women (Estimate = −0.11,p < 0.001), highest among White men (Estimate = −0.22,p < 0.001) and lowest in Black women (Estimate = −0.04,p = 0.457). Greater post‐retirement cognitive decline was also observed among participants who attended college (Estimate = −0.14,p = 0.016). While greater work complexity (Estimate = 0.92,p < 0.05) and higher income (Estimate = 1.03,p < 0.05) were related to better cognitive function at retirement, neither was significantly related to cognitive change after retirement.ConclusionCognitive functioning may decline at an accelerated rate immediately post‐retirement, more so in White adults and men than Black adults and women. Lifelong structural inequalities including occupational segregation and other social determinants of cognitive health may obscure the role of retirement in cognitive aging.
Randomised controlled trial of cultural-adapted and programme-adopted cognitive behavioural therapy for children and adolescents’ anxiety in Japan: protocol for a Multi-, Inter-, and Cross-cultural Clinical Child Study (MIXCS)
Authors: Takashina Hikari N , Ueda Satsuki , Sakai Mie , Takahashi Fumito , Sato Hiroshi , Hudson Jennifer L , Rapee Ronald M , Ishikawa Shin-ichi 
Published: July 2023

IntroductionThe primary objective of the Multi-, Inter-, and Cross-cultural Clinical Child Study (MIXCS) is to evaluate the hypothesis that the effects of cultural-adapted cognitive behavioural therapy (CA-CBT) and programme-adopted cognitive behavioural therapy (PA-CBT) for children and adolescents’ anxiety are both superior to a psychological control (moral education control: MEC) for reducing child and adolescent anxiety disorders and symptoms as well as related constructs. The secondary objective is to explore commonalities and differences in therapy factors between CA-CBT and PA-CBT.Method and analysisThe study has been designed as a randomised, controlled and assessor masked multicentre superiority trial with three groups: CA-CBT, PA-CBT and MEC. Primary outcome is remission of primary anxiety disorders evaluated by independent evaluators. Secondary outcomes are clinician’s severity ratings, child self-reported anxiety symptoms, depressive symptoms, cognitive errors and family accommodation, as well as parent-reported anxiety symptoms, and family accommodation. Competence and adherence of treatment, therapy factors in treatment sessions are also measured based on behavioural observation. Finally, satisfaction and comprehension are collected. We aim to recruit at least 99 families for the analysis. Treatment will be delivered weekly for 10 sessions and assessment will be conducted 2 weeks before the treatment (pre), 3 months after the base date when the treatment starts (post), 6 months (six months follow-up) and 12 months (12 months follow-up) after the postassessment.Ethics and disseminationThe MIXCS study was approved by Doshisha University Research Ethics Review Committee, Kwansei Gakuin University Institutional Review Board for Medical and Biological Research Involving Human Subjects and Shinshu University Certified Review Board of Clinical Research. Regardless of the results, the primary outcome will be published in a journal, and if the efficacy and effectiveness of CA-CBT and/or PA-CBT are empirically supported, the authors will encourage dissemination of the programmes including the assessment system through key stakeholders in education, health, and welfare areas.Trial registration numberUMIN000038128