bluuebunny/crossref_metadata_2025_split huggingface dataset:
A stitch of CD9 saves nine: CD9+ tissue-resident memory T cells in Sjogren's syndrome and autoimmunity
Authors: Li Dan , Zhang Song 
Published: August 2023

AbstractThis editorial underscores the role of CD9+ tissue-resident memory (Trm) cells in autoimmune diseases, specifically in Sjogren's syndrome, and points to potential implications for better understanding the nature of recurrent autoimmune flares. New findings from Chang et al. highlight the presence and functional role of CD8+ Trm cells in inflamed labial glands in Sjogren's syndrome patients. This, together with the noted expression of CD9 in these Trm cells, opens a new research avenue into the mechanistic understanding of autoimmune diseases. The editorial also emphasizes the need for further studies to answer pressing questions related to CD9+ Trm cell function and their role in autoimmune diseases.
Structural basis for the selective methylation of 5-carboxymethoxyuridine in tRNA modification
Authors: Yoo Jaehun , Lee Jangmin , Kim Jungwook 
Published: August 2023

Abstract
Posttranscriptional modifications of tRNA are widely conserved in all domains of life. Especially, those occurring within the anticodon often modulate translational efficiency. Derivatives of 5-hydroxyuridine are specifically found in bacterial tRNA, where 5-methoxyuridine and 5-carboxymethoxyuridine are the major species in Gram-positive and Gram-negative bacteria, respectively. In certain tRNA species, 5-carboxymethoxyuridine can be further methylated by CmoM to form the methyl ester. In this report, we present the X-ray crystal structure of Escherichia coli CmoM complexed with tRNASer1, which contains 5-carboxymethoxyuridine at the 5′-end of anticodon (the 34th position of tRNA). The 2.22 Å resolution structure of the enzyme-tRNA complex reveals that both the protein and tRNA undergo local conformational changes around the binding interface. Especially, the hypomodified uracil base is flipped out from the canonical stacked conformation enabling the specific molecular interactions with the enzyme. Moreover, the structure illustrates that the enzyme senses exclusively the anticodon arm region of the substrate tRNA and examines the presence of key determinants, 5-carboxymethoxyuridine at position 34 and guanosine at position 35, offering molecular basis for the discriminatory mechanism against non-cognate tRNAs.
Reconstructing interfacial manganese deposition for durable aqueous zinc–manganese batteries
Authors: Hu Yida , Liu Zhexuan , Li Lanyan , Guo Shan , Xie Xuefang , Luo Zhigao , Fang Guozhao , Liang Shuquan 
Published: August 2023

AbstractLow-cost, high-safety, and broad-prospect aqueous zinc−manganese batteries (ZMBs) are limited by complex interfacial reactions. The solid−liquid interfacial state of the cathode dominates the Mn dissolution/deposition process of aqueous ZMBs, especially the important influence on the mass and charge transfer behavior of Zn2+ and Mn2+. We proposed a quasi-eutectic electrolyte (QEE) that would stabilize the reversible behavior of interfacial deposition and favorable interfacial reaction kinetic of manganese-based cathodes in a long cycle process by optimizing mass and charge transfer. We emphasize that the initial interfacial reaction energy barrier is not the main factor affecting cycling performance, and the good reaction kinetics induced by interfacial deposition during the cycling process is more conducive to the stable cycling of the battery, which has been confirmed by theoretical analysis, quartz crystal microbalance with dissipation monitoring, depth etching X-ray photon-electron spectroscopy, etc. As a result, the QEE electrolyte maintained a stable specific capacity of 250 mAh g−1 at 0.5 A g−1 after 350 cycles in zinc−manganese batteries. The energy density retention rate of the ZMB with QEE increased by 174% compared to that of conventional aqueous electrolyte. Furthermore, the multi-stacked soft-pack battery with a cathodic mass load of 54.4 mg maintained a stable specific capacity of 200 mAh g−1 for 100 cycles, demonstrating its commercial potential. This work proves the feasibility of adapting lean-water QEE to the stable aqueous ZMBs.
Determinants of public sector efficiency: a panel database from a stochastic frontier analysis
Authors: Apeti Ablam Estel , Bambe Bao-We-Wal , Lompo Aguima Aime Bernard 
Published: August 2023

Abstract
This article provides a large dataset on PSE using a parametric approach, and covering 158 countries of all income levels, over the period 1990–2017. The analysis includes four sectors: education, health, infrastructure, and public administration. We further consider three efficiency indicators regarding the ‘Musgravian’ tasks for government: allocation, distribution, and stabilization. After computing the efficiency scores for our sample countries, we examine their determinants using a wide range of economic and institutional factors. Our key findings are that trade globalization, factor productivity, and institutional quality seem to be important determinants of total PSE. The results remain robust to alternative specifications and methods. Finally, we provide additional evidence by exploring the sensitivity of the main determinants to different country groups, considering the level of economic development, geographical regions, and fragile states.
Real-World Impact of Adjuvant Anti-HER2 Treatment on Characteristics and Outcomes of Women With HER2-Positive Metastatic Breast Cancer in the ESME Program
Authors: Le Du Fanny , Carton Matthieu , Bachelot Thomas , Saghatchian Mahasti , Pistilli Barbara , Brain Etienne , Loirat Delphine , Vanlemmens Laurence , Vermeulin Thomas , Emile George , Gonçalves Anthony , Ung Mony , Robert Marie , Jaffre Anne , Desmoulins Isabelle , Jouannaud Christelle , Uwer Lionel , Marc Ferrero Jean , Mouret-Reynier Marie-Ange , Jacot William , Chevrot Michaël , Delaloge Suzette , Diéras Véronique 
Published: August 2023

Abstract

Background
Although adjuvant cancer treatments increase cure rates, they may induce clonal selection and tumor resistance. Information still lacks as whether (neo)adjuvant anti-HER2 treatments impact the patterns of recurrence and outcomes of HER2-positive (HER2+) metastatic breast cancer (MBC). We aimed to assess this in the large multicenter ESME real-world database.

Patients and Methods
We examined the characteristics and outcomes (overall survival (OS) and progression-free survival under first-line treatment (PFS1)) of HER2+ patients with MBC from the French ESME program with recurrent disease, as a function of the previous receipt of adjuvant trastuzumab. Multivariable analyses used Cox models adjusted for baseline demographic, prognostic factors, adjuvant treatment received, and disease-free interval.

Results
Two thousand one hundred and forty-three patients who entered the ESME cohort between 2008 and 2017 had a recurrent HER2+ MBC. Among them, 56% had received (neo)adjuvant trastuzumab and 2.5% another anti-HER2 in this setting. Patients pre-exposed to trastuzumab were younger, had a lower disease-free interval, more HR-negative disease and more metastatic sites. While the crude median OS appeared inferior in patients exposed to adjuvant trastuzumab, as compared to those who did not (37.2 (95%CI 34.4-40.3) versus 53.5 months (95% CI: 47.6-60.1)), this difference disappeared in the multivariable model (HR = 1.05, 95%CI 0.91-1.22). The same figures were observed for PFS1.

Conclusions
Among patients with relapsed HER2+ MBC, the receipt of adjuvant trastuzumab did not independently predict for worse outcomes when adjusted to other prognostic factors.
Pre-existing Interstitial Lung Abnormalities and Immune Checkpoint Inhibitor-Related Pneumonitis in Solid Tumors: A Retrospective Analysis
Authors: Horiuchi Kohei , Ikemura Shinnosuke , Sato Takashi , Shimozaki Keitaro , Okamori Satoshi , Yamada Yoshitake , Yokoyama Yoichi , Hashimoto Masahiro , Jinzaki Masahiro , Hirai Ikuko , Funakoshi Takeru , Mizuno Ryuichi , Oya Mototsugu , Hirata Kenro , Hamamoto Yasuo , Terai Hideki , Yasuda Hiroyuki , Kawada Ichiro , Soejima Kenzo , Fukunaga Koichi 
Published: August 2023

Abstract

Background
Immune checkpoint inhibitors (ICIs) have demonstrated efficacy over previous cytotoxic chemotherapies in clinical trials among various tumors. Despite their favorable outcomes, they are associated with a unique set of toxicities termed as immune-related adverse events (irAEs). Among the toxicities, ICI-related pneumonitis has poor outcomes with little understanding of its risk factors. This retrospective study aimed to investigate whether pre-existing interstitial lung abnormality (ILA) is a potential risk factor for ICI-related pneumonitis.

Materials and Methods
Patients with non-small cell lung cancer, malignant melanoma, renal cell carcinoma, and gastric cancer, who was administered either nivolumab, pembrolizumab, or atezolizumab between September 2014 and January 2019 were retrospectively reviewed. Information on baseline characteristics, computed tomography findings before administration of ICIs, clinical outcomes, and irAEs were collected from their medical records. Pre-existing ILA was categorized based on previous studies.

Results
Two-hundred-nine patients with a median age of 68 years were included and 23 (11.0%) developed ICI-related pneumonitis. While smoking history and ICI agents were associated with ICI-related pneumonitis (P = .005 and .044, respectively), the categories of ILA were not associated with ICI-related pneumonitis (P = .428). None of the features of lung abnormalities were also associated with ICI-related pneumonitis. Multivariate logistic analysis indicated that smoking history was the only significant predictor of ICI-related pneumonitis (P = .028).

Conclusion
This retrospective study did not demonstrate statistically significant association between pre-existing ILA and ICI-related pneumonitis, nor an association between radiologic features of ILA and ICI-related pneumonitis. Smoking history was independently associated with ICI-related pneumonitis. Further research is warranted for further understanding of the risk factors of ICI-related pneumonitis.
Gardening and the Power of Engagement with Nature for Mental Well-Being
Authors: Brook Isis 
Published: August 2023

Abstract
The evidence is now well established that natural environments, nearby nature, and activities engaging with plants can improve mental well-being. This chapter will outline the literature that addresses, for example, therapeutic horticulture, increasing green spaces in urban environments, and prescribing time in nature. The literature reveals a picture of the helpfulness of plants and gardening activities for those with mental health problems, but also the requirement of nearby nature for everyone. The concepts examined here, such as the reasonable person model, nature deficit disorder, attention restoration, and biophilia, support the idea that some contact with nature is a human requirement. The processes involved in the human/plant relationship are examined through participant accounts in the literature and interrogation of the aesthetic elements involved in the experiential nature of gardening. Aesthetic engagement, and the shifts in our focus from self to world that it can bring about, present a speculative answer to why gardening can bring about positive and helpful mental states that support well-being.
An Aesthetics of Relating and Its (Therapeutic) Potentials
Authors: Fürholzer Katharina , Pröll Julia 
Published: August 2023

Abstract
In light of ongoing biomedical processes of globalization closely linked with the emergence of ‘medicoscapes’, the proposed article focusses on issues of transcultural psychiatry and intercultural psychotherapy from the viewpoint of literary criticism. Drawing on the importance (Critical) Medical Humanities recently attached to culture—and its crucial impact on (mental) illness experience—the main purpose of this paper is to relate, in a postcolonial theoretical framework, Western and non-Western conceptions of mental illness, health, and cure in order to explore the emerging contact zones and to overcome the unproductive ‘othering’ of medical exoticism considering non-Western forms of healing and therapy as mere curiosities. As key link we will consider the (trans-)cultural technique of narrating (life) stories as it appears in an anglophone and francophone corpus of (not only migrant) literature. As some sort of ‘third space’ or ‘contact zone’, literature, especially when governed by a migratory aesthetics of relating, can be seen as a constant reminder of the irreducible heterogeneity of (medical) cultures as well as a negotiating space that not only builds bridges between the ‘self’ and the ‘other’ but encourages to undertake a salutary ‘self-limitation’ of hegemonic (bio-)medical paradigms, as can be shown, for instance, by productive fictional ‘sinicizations’ of Western psychoanalysis.
Mirror. Lens. PuzzleBox. Metaphor.
Authors: Goldbloom Bloch William 
Published: August 2023

Abstract
Jorge Luis Borges, a brilliant autodidact, was a philosophic essayist, poet, literary theorist, and writer of remarkable short stories that contributed to the founding of a unique brand of scientific and mathematical magical realism. He was neither a scientist nor a mathematician, yet his short stories have inspired scientists and mathematicians—practitioners—in four distinct intertwined ways. First, his work acts as a mirror: many of the characters find themselves in a crisis of profound despair when confronted with the fundamental unknowability of the universe or imaginative representations thereof. Practitioners find ample opportunity to empathize! Second, the stories act as lens into interesting subjects and substantial ideas for practitioners to focus on. Third, many practitioners are drawn to intricate puzzles for recreation; Borges’s short stories appeal to that sensibility. Finally, the stories serve as bridges from practitioners to other audiences by providing a rich store of striking metaphors.
Esoteric Physiology and Subtle Body Systems
Authors: Hayes Glen A. 
Published: August 2023

Abstract
In this chapter, the author considers some of the numerous systems of esoteric physiology to be found in Hindu and Buddhist tantra—often known as the “yogic body” or “subtle body.” This alternative body has been construed in many different ways in tantric traditions, but it is typically of an esoteric nature, is accessed and inhabited via initiation and other ritual processes, is connected to breathing processes, reveals secret knowledge and magical powers, and is regarded as a microcosm. The author considers how esoteric physiology is best understood through Gavin Flood’s concept of the “entextualization of the body,” which allows us to consider the contexts and uses of specific subtle body systems. Flood demonstrates that the systems of the subtle body are not discrete ontological entities (as often claimed by modern yoga practitioners) but rather the expression of cosmologies and ritual systems in specific texts.
Metaphysical Idealists in Britain
Authors: Thomas Emily 
Published: August 2023

Abstract
Idealists agree that reality is somehow mental, holding, say, that reality comprises consciousness or spirit. Idealism can be developed in many different ways and, before the distinctive movement known as “British idealism” emerged, other idealisms were present in Britain. This chapter offers the first-ever study of female idealists in nineteenth-century Britain. It identifies six pertinent women, and focuses on three of them, exploring the idealist metaphysics of Constance Naden, Victoria Welby, and Arabella Buckley. It situates their idealisms in the context of Victorian metaphysics; shows that each developed a different kind of idealism, drawing on varied sources from Kant to Herbert Spencer; and contrasts their idealisms with one another.
Performance, Technology, and the Good Life
Authors: Roholt Tiger 
Published: August 2023

Abstract
This chapter explores the relations between musical instruments, performance, sociality, and well-being by drawing upon Albert Borgmann’s philosophy of technology. In-passing, Borgmann categorizes musical instruments as “focal things.” He does not consider the implications of this characterization; this chapter does. Borgmann does not place musical performance in the associated category, “focal practice”; this chapter does. Among the benefits of examining performance and instruments through Borgmann’s framework, we are given the conceptual tools for understanding just how some technologies make a positive contribution to performance (in terms of what the author calls “technological paraphernalia”) and just how other technologies threaten the focal practice of performance (what Borgmann calls “technological devices”). More broadly, Borgmann has a unique way of articulating what it is to treat performance and instruments as ends in themselves rather than as means. Through this articulation, we see that performance and instruments can contribute to a good life through what Borgmann calls “centering.”
Critical Listening and Authorial Agency as Radical Practices of Care
Authors: Bylica Kelly 
Published: August 2023

Abstract
Listening is often a unidirectional practice in North American music education, one that is used as a functional tool to help uncover the “right” or “best” answer to a posed question. Listening, however, can also be reframed as a multidimensional process wherein viewpoints and possibilities that represent the plurality of the world are explored. Through practical examples, this chapter considers the ways in which listening in both musical and dialogical encounters can serve as opportunities to honor and engage with the voices and experiences of students. When viewed as an opportunity to inquire into difference, such practices can help both students and educators question taken-for-granted norms, engage in musical risk-taking, and work toward more complex understandings of their experiences together through music.
France
Authors: Ruiz Fabri Hélène , Stoppioni Edoardo 
Published: August 2023

Abstract
Understanding what international law represents in France today requires understanding a complex set of layers and meanings. It is necessary to take a historical perspective and grasp the fundamental historical role that France played in forming international law as a power able to shape it according to its own political needs at certain periods in time. But it is also necessary to investigate the way international law exists in the everyday life of the national legal system: while different national constitutional systems implied an evolution from a strong dualism to a subtle monism, national judges introduced nuances in the textual option, most notably with the reassertion of the constitution’s primacy. Finally, international law operates in France through a set of traditions which translate into the methods that lawyers use to understand international law, the ways they are educated, and colouring the French approaches to international law.
Evolution of Modern Literature and Film
Authors: Sobchuk Oleg 
Published: August 2023

Abstract
The evolution of complex narratives, such as fictional books or films, is a fairly new area of cultural-evolutionary research. It gained momentum only recently, when researchers got access to large datasets of literature, movies, and other kinds of storytelling, allowing us to discover long-lasting historical trends and regularities. This chapter, first, discusses a theoretical question: in what sense do narratives evolve? More precisely, it focuses not on the transmission of stories themselves, but on the evolution of narrative forms, or techniques of storytelling. Then, the chapter proceeds to describing how content-based, or hedonic, selection influences the evolution of narrative forms—and briefly, the role of several other evolutionary mechanisms, such as drift and accumulation of innovations. Finally, the chapter schematically presents the methods used for studying the evolution of literature and film at a large scale: from manual coding to text mining and other computational techniques.
Sexual posttraumatic stress among investigators of child sexual abuse material
Authors: Gewirtz-Meydan Ateret , Mitchell Kimberly J , O’Brien Jennifer E 
Published: August 2023

Abstract
The current study aims to examine the sexual posttraumatic stress symptoms (sexual PTSS) among investigators of child sexual abuse material (CSAM). Previous findings indicated that sexual PTSS has a unique impact on mental health and well-being compared with traditional PTSS, highlighting a gap in the literature on how exposure to CSAM affects investigators, including their sexual lives. This study sought to fill this gap by examining the sexual PTSS of CSAM investigators. The sample included 500 participants (61% male and 37.4% female) who were police investigators, forensic examiners, and others connected with the criminal justice system across the USA. Participants answered questions about their CSAM exposure and mental health (depression, anxiety, PTSS, and sexual PTSS). The study found that the content of CSAM, mental health symptomatology, being a female investigator, and live streaming of CSAM were associated with increased sexual PTSS. The results suggest that viewing CSAM may affect the sexual response of some investigators and that certain aspects of the job may increase the risk of sexual PTSS. The study highlights the need for wellness programs to provide support related to the possible effects of CSAM on investigators’ sexual response.
Using machine learning to diagnose relativistic electron distributions in the Van Allen radiation belts
Authors: Killey S , Rae I J , Chakraborty S , Smith A W , Bentley S N , Bakrania M R , Wainwright R , Watt C E J , Sandhu J K 
Published: August 2023

Abstract
The behaviour of relativistic electrons in the radiation belt is difficult to diagnose as their dynamics are controlled by simultaneous physical processes, some of which may be still unknown. Signatures of these physical processes are difficult to identify in large amounts of data; therefore, a machine learning approach is developed to classify energetic electron distributions which have been driven by different mechanisms. A series of unsupervised machine learning tools have been applied to 7 yrs of Van Allen Probe Relativistic Electron-Proton Telescope data to identify six different typical types of plasma conditions, each with a distinctly shaped energy-dependent pitch angle distribution (PAD). The PADs at lower energies have shapes as expected from previous studies – either butterfly, pancake, or flattop, providing evidence that machine learning has been able to reliably classify the relativistic electrons in the radiation belts. Further applications of this technique could be applied to other space plasma regions, and data sets from inner heliospheric missions such as Parker Solar Probe and Solar Orbiter, to planetary magnetospheres and the JUICE mission. Understanding PADs across the heliosphere enables researchers to determine the physical mechanisms that drive pitch angle evolution and investigate their spatial and temporal dependence and physical properties.