bluuebunny/crossref_metadata_2025_split huggingface dataset:
Airborne dimethyl sulfide (DMS) cues dimethylsulfoniopropionate (DMSP) increases in the intertidal green alga Ulva fenestrata
Authors: Van Alstyne Kathryn L. , Butler Jennifer K. , Smith Neal 
Published: March 2023

AbstractAlthough the use of airborne molecules as infochemicals is common in terrestrial plants, it has not been shown to occur in an ecologically relevant context in marine seaweeds. Like terrestrial plants, intertidal plants spend part of their lives emersed at low tide and release volatile organic compounds (VOCs) into the air when they are grazed or physiologically stressed. We hypothesized seaweeds could use airborne VOCs as infochemicals and respond to them by upregulating a keystone defensive metabolite, dimethylsulfoniopropionate (DMSP). We conducted laboratory and field experiments in which Ulva fenestrata was exposed to airborne dimethyl sulfide (DMS), a volatile antiherbivore and antioxidant metabolite released when the seaweed is grazed or physiologically stressed. In the laboratory, U. fenestrata exposed to DMS had 43–48% higher DMSP concentrations, relative to controls, 6–9 days after exposure. In the field, U. fenestrata 1 m downwind of DMS emitters had 19% higher DMSP concentrations than upwind seaweeds after 11 days. To our knowledge, this is the first demonstration of a marine plant using an airborne molecule released when damaged to elicit defensive responses. Our study suggests that the ability to detect airborne compounds has evolved multiple times or before the divergence of terrestrial plants and green algae.
Overexpression of Physcomitrium patens cell cycle regulators leads to larger gametophytes
Authors: Peramuna Anantha , López Carmen Quiñonero , Rios Francisco Javier Astorga , Bae Hansol , Fangel Jonatan Ulrik , Batth Rituraj , Harholt Jesper , Simonsen Henrik Toft 
Published: March 2023

AbstractRegulation of cell division is crucial for the development of multicellular organisms, and in plants, this is in part regulated by the D-type cyclins (CYCD) and cyclin-dependent kinase A (CDKA) complex. Cell division regulation in Physcomitrium differs from other plants, by having cell division checks at both the G1 to S and G2 to M transition, controlled by the CYCD1/CDKA2 and CYCD2/CDKA1 complexes, respectively. This led us to hypothesize that upregulation of cell division could be archived in Bryophytes, without the devastating phenotypes observed in Arabidopsis. Overexpressing lines of PpCYCD1, PpCYCD2, PpCDKA1, or PpCDKA2 under Ubiquitin promotor control provided transcriptomic and phenotypical data that confirmed their involvement in the G1 to S or G2 to M transition control. Interestingly, combinatorial overexpression of all four genes produced plants with dominant PpCDKA2 and PpCYCD1 phenotypes and led to plants with twice as large gametophores. No detrimental phenotypes were observed in this line and two of the major carbon sinks in plants, the cell wall and starch, were unaffected by the increased growth rate. These results show that the cell cycle characteristics of P. patens can be manipulated by the ectopic expression of cell cycle regulators.
Biphasic oxygen tension promotes the formation of transferable blastocysts in patients without euploid embryos in previous monophasic oxygen cycles
Authors: Chen Hsiu-Hui , Lee Chun-I , Huang Chun-Chia , Cheng En-Hui , Lee Tsung-Hsien , Lin Pin Yao , Chen Chien-Hong , Lee Maw-Sheng 
Published: March 2023

AbstractThis study evaluated whether the concentration of biphasic O2 (5–2%) promotes the formation of qualified blastocysts (QBs) and euploid blastocysts and the probability of cycles with transferable blastocysts. The paired experimental design included a total 90 patients (180 cycles) without euploid blastocysts in previous monophasic O2 (5%) cycles were enrolled for an additional cycle of biphasic O2 (5–2%). In the biphasic O2 (5–2%) group, the QB rate (35.8%, 225/628) was significantly higher than that in the monophasic O2 (5%) group (23.5%, 137/582; p < 0.001). In addition, the euploid blastocyst number (0.5 ± 0.8) and the percentage of cycles with transferable blastocysts were significantly higher in the biphasic O2 (5–2%) group (57.8%, 52/90) than those in the monophasic O2 (5%) group (0 and 35.6%, 32/90, respectively; p < 0.01). Multivariable regression analysis also indicated that the QB rate and the probability of cycles with transferable blastocysts correlated with O2 tension (OR 1.535, 95% CI 1.325–1.777, and OR 3.191, 95% CI 1.638–5.679, respectively; p < 0.001). Biphasic O2 culture can be used as an alternative strategy to increase the euploid QBs and the probability of cycles with transferable blastocysts in patients with a poor prognosis.
Non-Abelian topological superconductivity in maximally twisted double-layer spin-triplet valley-singlet superconductors
Authors: Zhou Benjamin T. , Egan Shannon , Kush Dhruv , Franz Marcel 
Published: March 2023

AbstractRecent studies point to an exotic spin-triplet valley-singlet (STVS) superconducting phase in certain two-valley electron liquids, including rhombohedral trilayer graphene, Bernal bilayer graphene and ZrNCl, which nevertheless admits only trivial topology. Here, we predict that upon twisting two layers of STVS superconductors, a chiral $$f\pm {{{{{{{\rm{i}}}}}}}}{f}^{{\prime} }$$
f
±
i

f

′

-wave superconducting phase emerges near the ‘maximal’ twist angle of 30∘ where the system becomes an extrinsic quasi-crystal with 12-fold tiling. The resulting composite hosts an odd number of chiral Majorana edge modes and a single non-Abelian Majorana zero mode (MZM) in the vortex core. Through detailed symmetry analysis and microscopic modelling, we demonstrate that the non-Abelian topological superconductivity (TSC) forms robustly near the maximal twist when the isolated Fermi pockets coalesce into a single connected Fermi surface in the moiré Brillouin zone. Our results establish the large-twist-angle engineering, with distinct underlying moiré physics from magic-angle graphene, as a viable route toward non-Abelian TSC.
Pervasive hydrous carbonatitic liquids mediate transfer of carbon from the slab to the subarc mantle
Authors: Chen Wei , Zhang Guoliang , Keshav Shantanu , Li Yuan 
Published: March 2023

AbstractCarbonatitic liquids, as a medium for transferring carbon from the slab to the mantle at subarc depths, are thought to be restricted either to the hottest conditions or to be the hydrous melting of calcium-rich lithologies (i.e., carbonated gabbro and limestone rocks) in subduction zones. In this study, high-pressure experiments on carbonated hydrous pelites demonstrate that while silicate melts are produced at 2.5–4 GPa, hydrous carbonatitic liquids clearly dominate at 5–6 GPa. The stability of Ca-rich carbonate is strongly depressed by water at pressures exceeding ~4 GPa, promoting the formation of hydrous carbonatitic liquids at temperatures as low as ~850–900 °C; these temperatures correspond to intermediate thermal regimes at depths of 150–180 km. Hence, carbonatite production beneath arcs is more pervasive than previously thought, and the carbon cycle is most likely confined to depths of less than 200 km for many subduction zones.
Policy failures and energy transitions: the regulatory bricolage for the promotion of renewable energy in Mexico and Chile
Authors: Natorski Michal , Solorio Israel 
Published: March 2023

AbstractLatin American and Caribbean countries experience energy transitions in the context of crises affecting power electric systems. This article shows that policy failure recognition constitutes a window of opportunity for regulatory reforms supporting the diffusion of renewable energy. This argument is illustrated with the cases of Mexico and Chile, both of which are regional leaders in renewable energy after policy reforms. In both cases, policy failures were key drivers of energy transition since they mobilised different actors in the pursuit of policy changes. However, policy responses depended on how different policy failures were interpreted as the origins and solutions to perceived energy crises. This study distinguishes between critical and ordinary policy failures. In the case of a critical failure, dominant policy ideas are placed under contest; whereas, in an ordinary policy failure, the normative underpinning of the policy remains valid, and it fails only in implementation. Because policy change in the energy sector is incremental, reactions to failures lead to a policy bricolage combining novel and older policy goals and instruments. This process shifts the balance in the prioritisation of the energy trilemma components (energy equity, security of supply, and environmental sustainability).
Multi‐resonance dual‐polarised symmetrically cross‐slotted square patch antenna for 5G millimetre‐wave broadband applications
Authors: Wu Qi , Yu Haipeng , Yu Yiming , Gao Songtao , Yu Chen , Wang Haiming 
Published: March 2023

AbstractA dual‐polarised symmetrically cross‐slotted square patch (SCSSP) antenna with multimode resonance is proposed for 5G millimetre‐wave broadband applications. A symmetrical cross‐slot is etched on the square patch surface to change the original E‐field distribution where a whole square patch is cut into four disconnected equal parts. For both polarisations, this etching also tunes the resonance frequencies of the two modes to be sufficiently close to each other. Therefore, the antenna can realize good impedance performance within the wide designated bandwidth. Dual‐polarised radiation of the SCSSP is vertically excited by three bow‐tie‐shaped slots and fed by two orthogonal substrate integrated coaxial lines. Simulated and measured results show that the fabricated prototype achieves a broad overlapped impedance bandwidth of 50.0% (24–40 GHz), isolation higher than 30 dB between the two input ports, stable radiation pattern, and low cross‐polarisation over the operating band. Moreover, the proposed SCSSP antenna with compact size, planar shape, and simple vertical feeding is very well‐suited for two‐dimensional array design.
Impact of smart photovoltaic inverter control modes on medium‐voltage grid voltage and inverter lifetime: An experimental approach
Authors: Mohamed Ahmed , Saadeh George , Kaviani Ali Kashefi 
Published: March 2023

AbstractThis study relies on an experimental approach, utilising real data from multiple photovoltaic (PV) sites located in the US Northeaster region, to inspect how different inverter reactive and active power settings impact gird voltage regulation and inverter life expectancy. These voltage regulation schemes come at a cost for the operator. Data from different solar sites with inverters running at different reactive and active power settings were analysed to compare operational trade‐offs. These trade‐offs range from production losses to shortening the lifetime of the inverters. Voltage versus reactive power plots were analysed to show production losses, while the thermal analysis was used to correlate with the inverter life expectancy.
Identification of key immune‐related genes and immune infiltration in diabetic nephropathy based on machine learning algorithms
Authors: Sun Yue , Dai Weiran , He Wenwen 
Published: March 2023

AbstractBackgroundDiabetic nephropathy (DN) is a complication of diabetes. This study aimed to identify potential diagnostic markers of DN and explore the significance of immune cell infiltration in this pathology.MethodsThe GSE30528, GSE96804, and GSE1009 datasets were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified by merging the GSE30528 and GSE96804 datasets. Enrichment analyses of the DEGs were performed. A LASSO regression model, support vector machine recursive feature elimination analysis and random forest analysis methods were performed to identify candidate biomarkers. The CIBERSORT algorithm was utilised to compare immune infiltration between DN and normal controls.ResultsIn total, 115 DEGs were obtained. The enrichment analysis showed that the DEGs were prominent in immune and inflammatory responses. The DEGs were closely related to kidney disease, urinary system disease, kidney cancer etc. CXCR2, DUSP1, and LPL were recognised as diagnostic markers of DN. The immune cell infiltration analysis indicated that DN patients contained a higher ratio of memory B cells, gamma delta T cells, M1 macrophages, M2 macrophages etc. cells than normal people.ConclusionImmune cell infiltration is important for the occurrence of DN. CXCR2, DUSP1, and LPL may become novel diagnostic markers of DN.
Wirksamkeit von Kinesiotape-Anlagen bei mechanisch induzierten Nackenschmerzen – ein systematischer Review
Authors: Tscharnke Tim , Loudovici-Krug Dana , Lemhöfer Christina , Best Norman 
Published: March 2023

Zusammenfassung
Hintergrund Dieser Artikel bietet eine Zusammenfassung des Wissensstandes zum Thema der sportspezifischen Anwendung einer Kinesiotape-Intervention bei Nackenschmerz, welcher durch die Halte- bzw. Sitzposition beim Radsport hervorgerufen wird. Die vorliegende Übersicht fasst die Forschungsliteratur über die Wirksamkeit von Kinesiotape-Anlagen (KTA) auf das Schmerzempfinden, die Druckschmerzschwelle und den Bewegungsumfang im Bereich der Nackenmuskulatur bzw. des Musculus trapezius zusammen. Der Fokus lag konkret auf Studien im Radsportbereich.
Methoden Die Literaturrecherche erfolgte in den Datenbanken PubMed und Google Scholar. Die in Kombination genutzten Suchbegriffe waren „kinesio-tape“ und „backpain“, „neck-pain“, „kinesio-tape“ und „Musculus trapezius“ sowie „kinesio-tape“ und „cycling“.
Ergebnisse Insgesamt hat die Kombination der Schlüsselwörter 892 Ergebnisse geliefert. Davon hat die Suche in der Online-Datenbank von PubMed 192 Ergebnisse und in der Online-Datenbank von Google Scholar 700 Ergebnisse angezeigt. 874 Publikationen wurden aufgrund fehlender Spezifik und einem nicht den Anforderungen entsprechenden Anwendungsgebiet aussortiert. Drei weitere Studien sind als ,,doppelt“ eliminiert worden. 15 Studien haben die Einschlusskriterien erfüllt. Diese wurden inhaltlich und detailliert analysiert. Lediglich eine Studie setzt sich mit der Problematik des mechanisch induzierten Nackenschmerzes beim Radfahren auseinander. Die Wirkung des Kinesiotapes bezieht sich dabei auf eine Reduktion der Schmerzwahrnehmung und eine Aufrechterhaltung des zervikalen Bewegungsumfangs.
Schlussfolgerung Zahlreiche Studien befassen sich mit der Problematik von Schmerzzuständen und wie diesen mithilfe einer geeigneten KTA entgegengewirkt werden kann. Nur ein geringer Teil bietet Einblicke über die Wirksamkeit einer geeigneten Anwendung des Kinesiotapes bei mechanisch induzierten Nackenschmerzen.
Evaluation of Tuberculosis Risk under Interleukin-1 Inhibitor Agents
in Patients with Autoinflammatory Diseases: Experience from a Region with
Moderate Tuberculosis Prevalence
Authors: Karakaş Özlem , Dogan İsmail , Güven Serdar Can , Erel Şule , Erten Sukran 
Published: March 2023

Abstract
Background We aimed to investigate the rate of TBC reactivation in
patients with autoinflammatory conditions who had been followed up under
treatment with IL-1 antagonists in our clinic. We further aimed to evaluate
whether latent TBC screening and isoniazid prophylaxis before IL-1 inhibitor
treatment is beneficial in the prevention of reactivation.
Patients and Methods This study was designed as a cross-sectional and
observational study. It received the approval of the local ethics committee and
was therefore performed in accordance with the ethical standards laid down in
the 1964 Declaration of Helsinki and its later amendments. Adult patients who
had been followed up in our clinic under treatment with IL-1 antagonists were
evaluated with regard to whether they had a TBC infection before and after these
treatments and whether they had been screened for latent TBC infection before
IL-1 antagonist treatment and received prophylaxis. Clinical and laboratory data
were obtained from hospital records and via telephone interviews after the
patients had given their verbal consent to participate.
Results Fifty-nine patients under IL-1 antagonists were consecutively
enrolled. 58 were under follow-up with the diagnosis of familial Mediterranean
fever and one patient with a diagnosis of adult-onset Still’s disease.
35 patients (59.3%) were treated with anakinra and 24 (40.7%)
were treated with canakinumab. 12 (50%) of the canakinumab users had
previously received anakinra treatment and were switched to canakinumab due to
side-effects or ineffectiveness. The number of patients who underwent latent
tuberculosisc infection (LTBI) screening before treatment was 37
(62.7%); the number of patients who received prophylaxis was 13
(22%). None of the patients receiving IL-1 antagonists developed active
tuberculosis.
Conclusion Blocking the IL-1 pathway may be safe regarding the activation
of LTBI or development of a new tuberculosis infection even in locations with a
high geographical risk.
Generalized Infantile Myofibromatosis with Extensive Small Bowel
Involvement in a Neonate
Authors: Schubert Judit Pauline , Wößmann Wilhelm , Königs Ingo , Clauditz Till , Kordes Uwe , Reinshagen Konrad 
Published: March 2023

AbstractInfantile myofibromatosis is a rare benign congenital tumour that often regresses
spontaneously but may pose therapeutic challenges in its widespread visceral
form. We present the case of a full-term neonate with generalized infantile
myofibromatosis including ubiquitous subcutaneous and muscular nodules, a tumour
in the mastoid and disseminated intestinal involvement. The intestinal tumours
led to a mechanical ileus with intestinal perforation within the first days of
life. After partial small bowel resection and necessary proximal jejunostomy the
boy was dependent on total parenteral nutrition. Chemotherapy with vinblastine
and methotrexate was started and was temporarily supplemented with imatinib.
Feeding stayed impossible despite tumour shrinkage. At the age of 4.5 months,
restoration of intestinal continuity with further stricturoplasties was
performed which – for the first time – allowed complete oral
feeding. Chemotherapy was continued for further two months. Currently, the child
is in good general condition with growth and further disease regression. This
report suggests that massive visceral involvement of infantile myofibromatosis
may require extensive intestinal surgery, as conservative therapy cannot resolve
the disease and its sequelae.
Assessment of YouTube Videos about Urethral Stricture and Its Management
Authors: Tokuc Emre , Kayar Ridvan , Artuk Ilker , Koc Senem , Topaktas Ramazan , Akyuz Mehmet , Kanberoglu Huseyin , Öztürk Metin İshak 
Published: March 2023

Abstract
Purpose To evaluate the reliability, transparency, usability and technical quality of videos about urethral stricture and its management in the most common video-sharing website “YouTube”.

Methods We performed a video search on YouTube using the keywords “Urethral Stricture”, “Internal Urethrotomy” and “Urethroplasty”. After excluding the videos that did not meet the inclusion criteria, demographic data of each video was recorded and assessed with the validated DISCERN questionnaire, the Journal of the American Medical Association Benchmark Score (JAMAs) and the Global Quality Score (GQS). Additionally, the Urethral Stricture Video Score was developed by two experienced surgeons to assess the technical aspects. Videos were also compared with a view to their source of upload.

Results A total of 177 videos were analysed. Videos from “University” and “Other” had a significantly higher view ratio and video power index (VPI) than the rest (all p<0.05). For all mentioned scores, even though the video sources of “Society” and “University” had significantly higher scores than the rest (all p<0.05), all scores remained at a low to moderate level at each group.

Conclusion Even though universities, societies and organisations tend to upload better videos about the management of urethral stricture in terms of general quality, reliability, transparency and technical aspects, the online visual content about urethral stricture and its management needs to be improved in order to provide more reliable and qualified information for both clinicians and patients.
HOPE and DREAM: A Two-Clinic NICU Follow-up Model
Authors: Carlton Katherine , Adams Samuel , Fischer Elizabeth , Foy Andrew , Heffelfinger Amy , Jozwik Jenna , Kim Irene , Koop Jennifer , Miller Lauren , Stibb Stacy , Cohen Susan 
Published: March 2023

Objective The natural extension of inpatient-focused neonatal neurocritical care (NNCC) programs is the evaluation of long-term neurodevelopmental outcomes in the same patient population.
Clinical Design A dedicated and collaborative team of neonatologists, neonatal neurologists, neuropsychologists, neurosurgeons, physical medicine and rehabilitation physicians, and psychologists are necessary to provide personalized medicine, developmental assessments, and parental education for NNCC graduates. To achieve this goal, we devised a two-clinic follow-up model at Children's Wisconsin: HOPE (Healthy Outcomes Post-ICU Engagement) and DREAM: Developmentally Ready: Engagement for Achievement of Milestones) clinics. Those infants with significant neurologic diagnoses attend DREAM clinic, while all other high-risk neonatal intensive care unit (NICU) infants are seen in the HOPE clinic.
Conclusion These clinic models allow for a targeted approach to post-NICU care, which has improved family engagement and perceptions of value.
Key Points
Exposure to Maternal Diabetes during Pregnancy Is Associated with Aggravated Short-Term Neonatal and Neurological Outcomes following Perinatal Hypoxic–Ischemic Encephalopathy
Authors: Laval Nancy , Paquette Mariane , Talsmat Hamza , Marandyuk Bohdana , Wintermark Pia , Birca Ala , Pinchefsky Elana F , Tremblay Sophie 
Published: March 2023

Objective Infants of diabetic mothers (IDM) are at higher risk of perinatal morbidities and glycemic instability, but the impact of maternal diabetes on neonatal and neurological short-term outcomes of neonates with hypoxic–ischemic encephalopathy (HIE) remains poorly described. Our objective was to determine the impact of maternal diabetes on neonatal and neurological short-term outcomes following neonatal HIE.
Study Design This was a retrospective single-center study including 102 term neonates with HIE who received therapeutic hypothermia (TH) treatment between 2013 and 2020. Multiple regression analysis was used to assess the relationship between the presence of maternal diabetes and short-term outcomes.
Results Neonates with HIE and maternal diabetes exposure had a significantly lower gestational age at birth (38.6 vs. 39.7 weeks of gestation, p = 0.005) and a significantly higher mean birth weight (3,588 ± 752 vs. 3,214 ± 514 g, p = 0.012). IDM with HIE were ventilated for longer duration (8 vs. 4 days, p = 0.0047) and had a longer neonatal intensive care unit (NICU) stay (18 vs. 11 days, p = 0.0483) as well as took longer time to reach full oral feed (15 vs. 7 days, p = 0.0432) compared with neonates of nondiabetic mother. Maternal diabetes was also associated with an increased risk of death or abnormal neurological examination at discharge in neonates with HIE (odds ratio: 6.41 [1.54–26.32]).
Conclusion In neonates with HIE, maternal diabetes is associated with an increased risk of death or short-term neonatal morbidities, such as longer duration of ventilation, prolonged neonatal stay, greater need for tube feeding, and being discharged with an abnormal neurological examination. Strategies to prevent, reduce, or better control maternal diabetes during pregnancy should be prioritized to minimize complications after perinatal asphyxia.
Key Points