bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poliprotect vs Omeprazole in the Relief of Heartburn, Epigastric Pain, and Burning in Patients Without Erosive Esophagitis and Gastroduodenal Lesions: A Randomized, Controlled Trial
Authors: Corazziari Enrico Stefano , Gasbarrini Antonio , D'Alba Lucia , D'Ovidio Valeria , Riggio Oliviero , Passaretti Sandro , Annibale Bruno , Cicala Michele , Repici Alessandro , Bassotti Gabrio , Ciacci Carolina , Di Sabatino Antonio , Neri Matteo , Bragazzi Maria Consiglia , Ribichini Emanuela , Radocchia Giulia , Iovino Paola , Marazzato Massimiliano , Schippa Serena , Badiali Danilo 
Published: June 2023

INTRODUCTION:In the treatment of upper GI endoscopy-negative patients with heartburn and epigastric pain or burning, antacids, antireflux agents, and mucosal protective agents are widely used, alone or as add-on treatment, to increase response to proton-pump inhibitors, which are not indicated in infancy and pregnancy and account for significant cost expenditure.METHODS:In this randomized, controlled, double-blind, double-dummy, multicenter trial assessing the efficacy and safety of mucosal protective agent Poliprotect (neoBianacid, Sansepolcro, Italy) vs omeprazole in the relief of heartburn and epigastric pain/burning, 275 endoscopy-negative outpatients were given a 4-week treatment with omeprazole (20 mg q.d.) or Poliprotect (5 times a day for the initial 2 weeks and on demand thereafter), followed by an open-label 4-week treatment period with Poliprotect on-demand. Gut microbiota change was assessed.RESULTS:A 2-week treatment with Poliprotect proved noninferior to omeprazole for symptom relief (between-group difference in the change in visual analog scale symptom score: [mean, 95% confidence interval] −5.4, −9.9 to −0.1; −6.2, −10.8 to −1.6; intention-to-treat and per-protocol populations, respectively). Poliprotect's benefit remained unaltered after shifting to on-demand intake, with no gut microbiota variation. The initial benefit of omeprazole was maintained against significantly higher use of rescue medicine sachets (mean, 95% confidence interval: Poliprotect 3.9, 2.8–5.0; omeprazole 8.2, 4.8–11.6) and associated with an increased abundance of oral cavity genera in the intestinal microbiota. No relevant adverse events were reported in either treatment arm.DISCUSSION:Poliprotect proved noninferior to standard-dose omeprazole in symptomatic patients with heartburn/epigastric burning without erosive esophagitis and gastroduodenal lesions. Gut microbiota was not affected by Poliprotect treatment. The study is registered in Clinicaltrial.gov (NCT03238534) and the EudraCT database (2015-005216-15).
Surface deformation and damage of 2022 (M6.8) Luding earthquake in China and its tectonic implications
Authors: Chen Baixu , Yu Zhongyuan , Li Luwei , Zheng Rongying , Wu Chuanyong 
Published: June 2023

AbstractThe 2022 (M6.8) Luding earthquake on the Xianshuihe Fault Zone (XFZ) caused severe casualties and property losses, and surface deformation and damage of which is crucial for studying the earthquake hazard assessment. However, few intensive scientific understanding has obtained to date because of widespread coronavirus transmission, strong vegetation coverage, and post-earthquake paralyzed traffic. By integrating high-resolution satellite images, large-scale geomorphic mapping, and UAV surveys, we constrain coseismic fractures and ruptures along an NW-SE-trending surface deformation zone, with discontinuous geomorphic scarps,en echeloncracks, and bulges concentrated in the areas of Yanzigou, Moxi, Menghugang, and Xingfu villages near the epicenter. Field observation also shows that the zone extends nearly parallel to the pre-existing XFZ with a length of ∼35 km with variable widths and a maximum vertical displacement of ∼100 ± 10 cm. The earthquake-induced surface coseismic effects, such as landslides, rock falls, and collapses, caused damage to the area. The amplification effect of the topography and the improper aseismic design and poor constructions may be responsible for the spatial distribution of MM Intensity IX, which is larger than other previous earthquakes that occurred in the surrounding area with a similar tectonic setting.
“Waiter, there’s a fly in my soup!”: tipping behavior in restaurants as a function of food servers’ humor, opinion conformity, and other-enhancement
Authors: Seiter John S. , Weger Harry 
Published: June 2023

Abstract
The purpose of this field experiment was to examine whether food servers who used other-enhancement, opinion conformity, or humor would be rewarded with higher tips from restaurant customers than food servers who did not use such ingratiation tactics. Consistent with predictions, humor and simple opinion conformity resulted in significantly higher tip percentages compared to the control condition. In contrast, other-enhancement (i.e., compliments) and exaggerated opinion conformity did not. Humor also resulted in higher tips than all other tactics, except simple opinion conformity. These results and their implications are discussed.
International study on the prevalence of malnutrition in centralized care for colorectal cancer patients
Authors: Meissner Carl , Tiegges Svenja , Broehl Martin , Otto Ronny , Ridwelski Karsten 
Published: June 2023

Abstract

Objectives
Patients with different diseases may show signs of malnutrition both before and during the hospital stay. The presence of malnutrition may impact the recovery and length of stay and consequently the costs. Early identification of malnutrition is thus a critical factor. The objective of this multicenter study is to determine the prevalence of malnutrition in colorectal cancer centers. Another objective is to investigate possible consequences, such as complications or length of stay. In addition, the study aims to demonstrate the relevance of nutrition management in colorectal cancer centers. At the same time, relevant requirements clearly demanded by the Certification Commission for Certified Colorectal Cancer Centers are met through implementation of the study.

Methods
Between 2019 and 2021, patients in colorectal cancer centers were examined in the preoperative phase. In addition to questions about patients’ state of health and nutrition, the validated screening forms—Subjective Global Assessment (SGA) and Nutritional Risk Screening Tool 2002 (NRS 2002)—were used to assess malnutrition. The data were processed by univariate analysis.

Results
In total, data records of 3,102 patients were evaluated. The mean age of the participants was 68.5 ± 11.9 years, and their average body mass index (BMI) was 26.8 ± 5.3 kg/m2. The SGA questionnaire indicated that 23 % of the participants suffered from malnutrition and 38 % were at risk of malnutrition (NRS≥3). Malnutrition was found more frequently in patients with colorectal carcinomas than in patients with rectal carcinomas (53.1 vs. 32.1 %). The length of stay in hospital and the rate of complications were significantly higher when malnutrition was identified.

Conclusions
Approximately one in three to four patients with a colorectal carcinoma has an increased risk of malnutrition. The two screening methods calculated a different prevalence (23 and 38 %). Any malnutrition that is present demonstrably has a significant impact both on the rate of complications and the length of stay and may therefore have a decisive influence on the costs. The results of this multicenter study underscore the need for systematic screening for malnutrition and at the same time should increase clinics awareness of the importance of establishing a nutrition management policy.
A symmetry-protected exceptional ring in a photonic crystal with negative index media
Authors: Isobe Takuma , Yoshida Tsuneya , Hatsugai Yasuhiro 
Published: June 2023

Abstract
Non-Hermitian topological band structures such as symmetry-protected exceptional rings (SPERs) can emerge for systems described by the generalized eigenvalue problem (GEVP) with Hermitian matrices. In this paper, we numerically analyze a photonic crystal with negative index media, which is described by the GEVP with Hermitian matrices. Our analysis using COMSOL Multiphysics® demonstrates that a SPER emerges for photonic crystals composed of split-ring resonators and metal-wire structures. We expect that the above SPER can be observed in experiments as it emerges at a finite frequency.
Molecular and solid-state topological polaritons induced by population imbalance
Authors: Pannir-Sivajothi Sindhana , Stern Nathaniel P. , Yuen-Zhou Joel 
Published: June 2023

Abstract
Strong coupling between electronic excitations in materials and photon modes results in the formation of polaritons, which display larger nonlinearities than their photonic counterparts due to their material component. We theoretically investigate how to optically control the topological properties of molecular and solid-state exciton–polariton systems by exploiting one such nonlinearity: saturation of electronic transitions. We demonstrate modification of the Berry curvature of three different materials when placed within a Fabry–Perot cavity and pumped with circularly polarized light, illustrating the broad applicability of our scheme. Importantly, while optical pumping leads to nonzero Chern invariants, unidirectional edge states do not emerge in our system as the bulk-boundary correspondence is not applicable. This work demonstrates a versatile approach to control topological properties of novel optoelectronic materials.
Scalable high Q-factor Fano resonance from air-mode photonic crystal nanobeam cavity
Authors: Sun Fujun , Li Zhihua , Tang Bo , Li Bin , Zhang Peng , Liu Ruonan , Yang Gang , Huang Kai , Han Zhe , Luo Jun , Wang Wenwu , Yang Yan 
Published: June 2023

Abstract
Fano resonance from photonic crystal nanobeam cavity (PCNC) is important building block for large-scale photonic integrated circuits (PICs) to enable photonic switches and sensors with superior characteristics. Nevertheless, most state-of-the-art demonstrations rely on electron beam lithography (EBL) and operate in dielectric mode. Hence, we theoretically, numerically and experimentally present the characteristics of Fano resonance from optical interference between the discrete state of air-mode PCNC and the continuum mode of side-coupled line-defect waveguide with partially transmitting element (PTE) using deep ultraviolet (DUV) lithography for the first time. Experimentally high average Q-factor of ∼1.58 × 104 is achieved for 30 measured devices, which indicates the feasibility of mass manufacture of high-Q Fano resonance from air-mode PTE-PCNC. Additionally, the thermo-optic bi-stability and thermal tuning characterizations of the proposed device are discussed. This work will contribute to building ultra-compact lab-on-chip resonance-based photonic components.
Nanoparticles for the potential treatment of Alzheimer’s disease: A physiopathological approach
Authors: Navarro Martínez Nicolás , Toledo Hernández Jorge , Morales Javier O. 
Published: June 2023

Abstract
Alzheimer’s disease (AD) is a multifactorial neurodegenerative central system disease with a high prevalence among the elderly and is the most common form of dementia. Oxidative stress is crucial on AD pathogenesis and leads to deposition of neurofibrillary tangles and Aβ plaques; therefore, the use of natural antioxidants or ROS scavengers could help avoid the formation of these aggregates. Similarly, Aβ-degrading/anti-aggregating molecules could help arrest AD progression. Otherwise, traditional anti-Alzheimer drugs such as acetylcholinesterase inhibitors help improve memory and attention deficits. Nevertheless, all these drugs are extensively metabolized, have low plasma concentration, and cannot cross the blood–brain barrier freely. This review discusses different strategies for nanocarrier conjugation of these drugs for brain targeting and delivery, and new approaches on AD treatment according to the most accepted hypotheses of AD pathogenesis. Although none of the existent compounds or drugs can completely arrest the disease’s progression, nanocarrier development of anti-Alzheimer drugs could help delaying the initial or late stages of neurodegeneration. The discovery of new and more complex nanosystems with multiple approaches in AD treatment is needed and will be the next step in AD treatment in the near future.
Investigation of different nanoparticles properties on the thermal conductivity and viscosity of nanofluids by molecular dynamics simulation
Authors: Zhang Ruihao , Qing Shan , Zhang Xiaohui , Luo Zhumei , Liu Yiqing 
Published: June 2023

Abstract
The mechanisms of thermal conductivity enhancement and the factors influencing viscosity are of great interest in the study of nanofluids, while molecular dynamics (MD) simulations considering nanofluids provide more accurate predictions of microscopic properties than conventional experimental studies. MD simulations of non-equilibrium molecular dynamics and reversing perturbation non-equilibrium molecular dynamics methods were used to study thermal conductivity and viscosity, taking into account a variety of influencing factors, as well as nanoparticle material and volume fraction. Through the analysis of the number density distribution, radial distribution function (RDF), and mean square displacement (MSD), the influences of different nanoparticles (Ag, Cu, Au, and Fe) were described and investigated: Ag particles contribute to 47.0% increase in thermal conductivity of 2.5 vol% nanofluids; Au particles improved the viscosity of 2.5 vol% nanofluids by 20.2%; the number density distribution showed positive linear relationship with the atomic mass; the results of MSD and RDF (mean square displacement and radial distribution function) in combination indicated a positive effect of interfacial nanolayer. The results of this research provide important perspectives for comprehending the impacts of multiple nanoparticles on the micro-thermal properties of nanofluids and also highlight the simulation potential of Au–Ar nanofluids.
Consensus and Ideology in Courts: An Application to the Judicial Committee of the Privy Council
Authors: Amaral-Garcia Sofia , dalla Pellegrina Lucia , Garoupa Nuno 
Published: June 2023

Abstract
This article supports the view that, while judges suppress dissent when dissenting is too costly, the cost of dissenting depends on the political dimension of the issue broached. It contends that judges who disagree may nevertheless try to safeguard integrity and legitimacy in political disputes by presenting a public impression of unity. We muster evidence from the United Kingdom, specifically, votes from the Judicial Committee of the Privy Council (JCPC) between 1998 and 2011. We demonstrate through statistical analysis that judges are likelier to suppress dissent in devolution cases, which are characterized to be more political in character, than in Commonwealth appeals, which are more mundane in nature. We find that, while consensus on domestic issues reflects the absence of disagreement across judicial ideologies, judges have stronger conflicting positions on issues concerning devolution, but tend to suppress their propensity to dissent. This finding confirms that the JCPC wants to appear cohesive to give an image of greater authority on decisions of predominantly political content.
Die
Gesetze der Form
aus der Sicht kategorientheoretischer Methoden
Authors: Tydecks Walter 
Published: June 2023

Zusammenfassung
In der Mathematik hat sich seit dem 19. Jahrhundert eine graphische Wende vollzogen. Mit der Kategorientheorie werden statt Zahlen ihre Beziehungen zueinander zum Gegenstand der Wissenschaft. Sie werden mit Pfeilen dargestellt. Das wird auf den Formkalkül von Spencer-Brown übertragen: (i) Ablösung der Markierung durch den Pfeil → und seiner Verlaufsformen. (ii) Ablösung des Re-entry-Zeichens durch kommutative Diagramme der Kategorientheorie und ihrer Bewegungsrichtungen. (iii) Einbeziehung der Dynamik von Beobachtern und ihrer Sichtweisen in ein erweitertes, dreistufiges Geschehen.
Mann-Dotson's algorithm for a countable family of non-self Lipschitz mappings in hyperbolic metric space
Authors: Patel Prashant , Shukla Rahul 
Published: June 2023

Abstract
The aim of this article is to present some

Δ

\Delta

-convergence and strong convergence results for a countable family of non-self mappings. More precisely, we employ Mann-Dotson’s algorithm to approximate, common fixed points of a countable family of non-self

L

n

{L}_{n}

-Lipschitz mappings in hyperbolic metric spaces.
Temperature and pressure effects on the response behavior of anemometers
Authors: Roß Alina , Balaresque Nicholas , Fischer Andreas 
Published: June 2023

Abstract
Cup anemometers are within the most used wind speed sensors for the wind energy industry. Wind tunnel calibrations under controlled conditions are required, but during operation uncontrolled environmental conditions occur. This is accounted for in the IEC 61400-50-1:2022 international wind measurements standard, which specifies sensor classification based on their response to external conditions, due to the influence parameters turbulence, air temperature, density, and upflow angle. Temperature and density effects are not covered appropriately in the IEC 61400-50-1:2022, since it assumes that air temperature only influences the bearing friction of a cup anemometer. No guidance is provided on evaluating variations in density, which depends on temperature and pressure. To investigate this, two cup anemometers are measured in Deutsche WindGuard’s Climatic Wind Tunnel, where density is changed by varying pressure and temperature independently. The results show that the sensor’s response to temperature can have other effects than an increase in ball bearing friction. Using pressure or temperature to modify density can even cause opposing results. Hence, varying temperatures and pressures independently is crucial to characterize a sensor’s response. The results correspond to cup anemometers, but the methodology is applicable on all sensors.
SRSF3 shapes the structure of miR‐17‐92 cluster RNA and promotes selective processing of miR‐17 and miR‐20a
Authors: Ratnadiwakara Madara , Bahrudeen Mohamed NM , Aikio Erika , Takabe Piia , Engel Rebekah M , Zahir Zileena , Jardé Thierry , McMurrick Paul J , Abud Helen E , Änkö Minna‐Liisa 
Published: June 2023

AbstractMicroRNA (miRNA) biogenesis is tightly regulated to maintain distinct miRNA expression patterns. Almost half of mammalian miRNAs are generated from miRNA clusters, but this process is not well understood. We show here that Serine‐arginine rich splicing factor 3 (SRSF3) controls the processing of miR‐17‐92 cluster miRNAs in pluripotent and cancer cells. SRSF3 binding to multiple CNNC motifs downstream of Drosha cleavage sites within miR‐17‐92 is required for the efficient processing of the cluster. SRSF3 depletion specifically compromises the processing of two paralog miRNAs, miR‐17 and miR‐20a. In addition to SRSF3 binding to the CNNC sites, the SRSF3 RS‐domain is essential for miR‐17‐92 processing. SHAPE‐MaP probing demonstrates that SRSF3 binding disrupts local and distant base pairing, resulting in global changes in miR‐17‐92 RNA structure. Our data suggest a model where SRSF3 binding, and potentially its RS‐domain interactions, may facilitate an RNA structure that promotes miR‐17‐92 processing. SRSF3‐mediated increase in miR‐17/20a levels inhibits the cell cycle inhibitor p21, promoting self‐renewal in normal and cancer cells. The SRSF3‐miR‐17‐92‐p21 pathway operates in colorectal cancer, linking SRSF3‐mediated pri‐miRNA processing and cancer pathogenesis.
Kelayakan Produk Lenan Rumah Tangga dari Limbah Tekstil dengan Teknik Paquiw
Authors: Arsetyaji Siswanti Ade , Widowati Widowati , Mandasari Agistiana 
Published: June 2023

Kelayakan diartikan sebagai kepantasan atau kepatutan, kelayakan produk lenan rumah tangga dari limbah tekstil dengan teknik paquiw diuji kelayakan oleh validator produk untuk mengetahui bagaimana tingkat kelayakan terhadap produk tersebut. Kelayakan produk dapat dilihat dari mutu barang atau produk dengan menggunakan bahan baku yang ada di kampus unnes khususnya jurusan Tata Busana yang ada sekitar 30% sisa limbah tekstil yang tidak digunakan.
Tujuan dari penelitian ini adalah untuk mengetahui kelayakan hasil dari produk lenan rumah tangga yang berupa sarung bantal dan taplak meja dari limbah tekstil dengan mengaplikasikan berbagai macam teknik paquiw yang di tinjau dari aspek estetika maupun ekonomi dengan menggunakan teori tentang kelayakan yang berupa desain, bahan baku, cara pembuatan, merek, kemasan, dan harga. Obyek pada penelitian ini menggunakan sampling insidental yang artinya teknik penentuan sampel yang berdasarkan kebetulan, yaitu siapa saja yang secara kebetulan/insidental bertemu dengan peneliti dapat digunakan sebagai sampel.
Uji kelayakan dengan melibatkan 1 validator produk dan 2 panelis ahli dilakukan untuk mengetahui kualitas kelayakan apakah layak atau tidak untuk digunakan dan sebelum angket disebar kepada para responden. Untuk soal kelayakan apakah valid atau tidak itu dilakukan dengan melibatkan 20 responden ujicoba tidak terlatih untuk mengetahui lebih dalam tingkat dari soal dan produk tersebut. Angket uji kelayakan dilakukan oleh 30 responden untuk mengetahui tingkat kelayakan tertentu. Data hasil uji kelayakan dianalisis dengan menggunakan rumus korelasi product moment dilanjutkan dengan data distribusi frekuensi. Hasil uji kelayakan menunjukkan adanya perbedaan yang nyata pada produk lenan rumah tangga dari aspek desain, bahan baku, cara pembuatan, merek, dan harga namun tidak dengan kemasan. Tingkat kelayakan paling tinggi didapatkan oleh aspek desain, bahan baku, dan cara pembuatan. Hasil dari uji kelayakan menunjukkan bahwa hasil dari panelis 91,11% sangat layak, Ujicoba 100% valid, dan Responden 94,22% sangat layak
Agresi Militer Belanda I Dalam Perspektif Sejarah Lokal Untuk Pembelajaran Sejarah di SMA
Authors: Dumadi Slamet , Romadi Romadi 
Published: June 2023

Pembelajaran sejarah akan menarik perhatian peserta didik manakala dapat memberikan keberartian terhadap topik yang sedang dibahas. Salah satu strategi yang dapat dilakukan oleh guru adalah dengan mengaitkan dan ”membidik” materi dari sisi sejarah lokal atau kedaerahan. Peristiwa-peristiwa yang jauh dalam pemahaman peserta didik didekatkan oleh guru dengan tinggalan yang terdapat di daerah sekitar. Materi sejarah tentang Mempertahankan Kemerdekaan dan Agresi Militer Belanda di kelas XI semester 1 dapat diupayakan oleh guru dengan tinjauan Sejarah Lokal. Langkah yang dapat dilakukan oleh seorang guru agar dapat melakukan ini adalah memperbanyak literasi dengan membaca dan menggali informasi dari orang-orang di lingkungan sekitar, karena dimungkinkan peristiwa-peristiwa itu belum tertulis pada buku-buku paket. Dengan strategi ini peserta didik akan merasakan keberartian dan sekaligus memberikan kebanggaan terhadap daerahnya.
Kata Kunci: mempertahankan kemerdekaan, agresi militer, sejarah lokal
The teaching of history will capture the attention of students when it can provide significance to the topics being discussed. One strategy that teachers can employ is by connecting and “targeting” the material from a local or regional historical perspective. Distant events that may be difficult for students to grasp are brought closer by the teacher through artifacts found in the surrounding area. The history curriculum on the Defense of Independence and Dutch Military Aggression in the first semester of eleventh grade can be approached by teachers with a focus on Local History. To accomplish this, a teacher can increase literacy by reading and gathering information from individuals in the local community, as it is possible that these events have not been documented in textbooks. Through this strategy, students will experience the significance of the subject matter and simultaneously develop pride in their region.
Keywords: defense of independence, military aggression, local history