bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the 5‐year milestone: Long‐term survivorship of melanoma patients treated off‐trial with anti‐PD‐1
Authors: Loo Kimberly , Kalvin Hannah L. , Panageas Katherine S. , Callahan Margaret K. , Chapman Paul B. , Momtaz Parisa , Shoushtari Alexander N. , Wolchok Jedd D. , Postow Michael A. , Warner Allison Betof 
Published: April 2023

AbstractLittle is known about the long‐term outcomes of anti‐PD‐1 treated patients with melanoma beyond 5 years, especially for patients treated off clinical trials. This retrospective cohort study includes patients with unresectable stage III/IV nonuveal melanoma treated with anti‐PD‐1 off‐trial at Memorial Sloan Kettering Cancer Center between 2014 and 2017 who survived at least 5 years following their first anti‐PD‐1 dose (N = 139). We characterized overall survival (OS), melanoma‐specific survival (MSS) estimates, treatment‐free survival rates, and subsequent treatment courses. Median follow‐up among 5‐plus year survivors (N = 125) was 78.4 months (range 60.0–96.3). OS at year 7 (2 years post 5‐year landmark) was 90.1% (95% CI: 83.0%–94.3%). Fourteen deaths occurred, seven due to melanoma. MSS at year 7 (2 years post 5‐year landmark) was 95.0% (95% CI: 33.5%–95.2%). In patients who completed anti‐PD‐1 based therapy and did not require subsequent treatment by 5 years (N = 80), the probability of not requiring additional treatment for an additional 2 years was 95.7% (95% CI: 91.0%–100%). Patients treated with anti‐PD‐1 regimens off clinical trials who survive at least 5 years from initial anti‐PD‐1 treatment can be reassured of their excellent long‐term prognosis, particularly if they did not require additional melanoma treatment during the first 5 years.
Bioeconomic modelling in tilapia aquaculture: A review
Authors: Dorantes‐de‐la‐O Juan Carlos R. , Maeda‐Martínez Alfonso N. , Espinosa‐Chaurand Luis D. , Garza‐Torres Rodolfo 
Published: April 2023

AbstractThe global production of aquatic resources is increasing at the rate of 3.3 million tons per year, main thanks to aquaculture. However, this industry is considered by financial institutions as high risk due to failures caused by epizootics, natural disasters and poor planning and monitoring. Bioeconomic modelling is a progressive branch of social science that seeks to integrate the disciplines of economics and biology to create theories that better explain economic events using a biological basis and vice versa. This should be used in aquaculture to plan, monitor, and determine cost‐effectiveness and risk, to reduce uncertainty and increase profits of ongoing or new projects. A meta‐analysis of the literature on bioeconomic modelling in aquaculture during 26 years (1994─2020) was performed, using four search engines. Sixty‐eight articles were published in 23 journals, on 25 groups of species or species. The most studied were shrimp, tilapia, seabream, salmon and carp. From these, 12 articles dealt with tilapia models that shared similar biological, management and economic sub‐models. In the 26‐year analysis, the global scientific productivity in this field is low (2.6 articles/year) in relation to the growth of world aquaculture. Bioeconomic modelling peaked during the decade from 2004 to 2014 with 5.6 papers/year, but then declined to only 0.83 articles/year from 2015 to 2020. This is possibly due to the low diffusion among producers, planners and financial institutions of the advantages of the models and the difficulty to use them if friendly and readily available software is lacking.
Encounters with the Pre‐Nicene ChristLearning Christ: Ignatius of Antioch and The Mystery of Redemption, GregoryVall, The Catholic University of America Press, 2021 (ISBN 978‐0‐8132‐3478‐6), xiv + 402 pp., pb $34.95Clement and Scriptural Exegesis: The Making of a Commentarial Theologian, H.Clifton Ward, Oxford University Press, 2022 (ISBN 978‐0‐19‐286336‐2), xiv + 240 pp., hb £90Cross and Creation: A Theological Introduction to Origen of Alexandria, Mark E.Therrien, The Catholic University of America Press, 2022 (ISBN 978‐0‐8132‐3530‐1), xxiv + 304 pp., pb $34.99Origen and the Emergence of Divine Simplicity Before Nicaea, PuiHim Ip, University of Notre Dame Press, 2022 (ISBN 978‐0‐268‐20361‐0), xx + 276 pp., hb $85
Authors: O'Leary Joseph S. 
Published: April 2023

AbstractThese four books, all exemplary, attest the vibrancy of patristic scholarship today, and especially the fascination which the pre‐Nicene period increasingly exerts. Stepping back behind Nicaea demands a refined sense for the texture of history, which may bring to light possibilities later lost as well as tensions later smothered. The four authors have illuminated afresh the theological profiles of Ignatius, Clement, and Origen, and also the figure of Christ as it emerges in these pristine centuries between the New Testament and Nicaea.
Imitating God and Familiar Identity: An Exploration in Developmental Psychology, Theology, and Ecclesial IdentityMarried Priests in the Catholic Church, Adam A. J.Deville (ed.), University of Notre Dame Press, 2021 (ISBN 978‐0‐268‐20010‐7), XXVI + 350 pp., pb $35Made in the Image of God: Being Human in the Christian Tradition, MichaelFuller, and DavidJasper (eds), Sacristy Press, 2021 (ISBN 978‐1‐78959‐170‐5), x + 282 pp., pb £24.99Forming Resilient Children: The Role of Spiritual Formation for Healthy Development, Holly CattertonAllen, IVP, 2021 (ISBN 978‐1‐5140‐0172‐1), x + 190 pp., pb $24
Authors: Farris Joshua R. 
Published: April 2023

AbstractThe nature of familial identity is central to a growing number of theological works. The authors of the volumes here each represent a different set of issues, disciplines, and perspectives. The discussions, ironically, center around family. Made in the Image of God gives the readers a series of reflections on diverse theological topics oscillating around the image and identity. Forming Resilient Children is unlike Made in the Image of God in that it is not strictly speaking a theological reflection on diverse issues, but a work of developmental psychology focusing on the nature of the child and the familial context for the child. Married Priests in the Catholic Church offers the reader a series of ecclesial engagements on the topic of the vocation of priesthood as either married or celibate. Overlapping with the previous two volumes in content by touching on identity, the image of God, and the nature of creaturely relations to God, Married Priests is, in one sense, a sustained reflection on the meaning of familial and organic identity (as an image of God) to the Church.
Integrating the entrepreneurial mindset into solar energy statistical analysis and performance modeling
Authors: Bosman Lisa , Soto Esteban , Varela Thaís Ferraz , Wollega Ebisa 
Published: April 2023

AbstractStatistical knowledge is required for students in a range of disciplines. However, there are limited educator resources that exist for applying statistics to solve real‐world problems. This investigation provides one approach to teaching statistics using entrepreneurial‐minded learning (as a way to connect real‐world applications and value creation with problem‐solving and curiosity) in the context of solar energy. Both the ready‐to‐use teaching intervention and assessment of student learning details are provided for an undergraduate course on Introductory Statistics. The teaching intervention includes a series of seven lesson plans (and three extension projects) that educators can use in an introductory statistics course.
HLA antibodies in fetal and neonatal alloimmune thrombocytopenia
Authors: Colvin Zachary A. , Schiller Jennifer , Tsaih Shirng‐Wern , Sharma Ruchika , Grace Rachael F. , McIntosh Jennifer J. , Curtis Brian R. 
Published: April 2023

AbstractBackgroundFetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antibodies against human platelet antigens (HPA). However, in many cases that meet clinical criteria for the condition, maternal sera do not have HPA antibodies. In studies examining whether human leukocyte antigen (HLA) antibodies cause FNAIT, the results are limited and inconclusive. This study sought to examine whether clinically suspected FNAIT cases with absent maternal HPA antibodies had different HLA antibody strength and specificity compared to controls.Study Design and MethodsA retrospective case–control study assessed class I HLA antibody strength and specificity in cases submitted for testing to Versiti, Wisconsin. There were 813 cases that met initial screening criteria, but written consent could only be obtained for 50. After review of medical records and expert panel review, 31 cases with clinical criteria of FNAIT and maternal HLA but not HPA antibodies were included. Each case was matched for maternal age, gestational age at delivery, parity, and race/ethnicity to two controls from unaffected pregnancies that had maternal serum HLA antibodies.ResultsFNAIT cases were found to have both significantly higher HLA antibody strength, measured by mean fluorescence index (MFI), and broader HLA antibody specificity at antigen epitope level, compared to matched controls (p < .001). p‐values remained significant after controlling for parity and gestational age at delivery.DiscussionAdditional studies are needed to further examine whether the strong HLA antibodies identified in HPA‐antibody‐negative cases directly cause neonatal thrombocytopenia and whether prenatal treatment may be warranted in select cases to prevent recurrence.
On the error term in a mixed moment of L‐functions
Authors: Khan Rizwanur , Zhang Zeyuan 
Published: April 2023

AbstractThere has recently been some interest in optimizing the error term in the asymptotic for the fourth moment of Dirichlet L‐functions and a closely related mixed moment of L‐functions involving automorphic L‐functions twisted by Dirichlet characters. We obtain an improvement for the error term of the latter.
Hydrodynamic Coefficients of Generic Subsea Modules in Forced Oscillation Tests—Importance of Structural Elements
Authors: Prsic Mia Abrahamsen , Solaas Frøydis , Kristiansen Trygve 
Published: April 2023

Abstract
A systematic study of hydrodynamic coefficients for simplified subsea modules has been performed to support the estimation of the coefficients needed for planning of subsea installation operations. The coefficients are assessed for a nearly two-dimensional test setup. The tests are performed as forced oscillations at various amplitudes and periods, representing the forces on the module lowered through the water column. The importance of each of the main components of the subsea modules—mudmat, protection roof, and process equipment of different shapes inside the modules are studied in fully submerged condition. Results for the module elements, generic contents, and different combinations of these elements are presented. For the tested modules, damping is generally the dominating hydrodynamic force. However, the presence of the content inside the modules will generally increase the importance of added mass. Estimation of the hydrodynamic coefficients by summation of the coefficients for the individual structure elements generally overestimates the damping, compared to the coefficients measured for the complete modules. For added mass, estimation based on summation gives generally good results.
Dry Sliding Wear Performances of AA5052 Hybrid Composite Brake Disc Materials Reinforced With In Situ Synthesized TiC and Multi-Walled Carbon Nanotube
Authors: Samal Priyaranjan , Vundavilli Pandu R. 
Published: April 2023

Abstract
In this research, aluminum alloy AA5052-based hybrid metal matrix composites (MMCs) were fabricated using in situ synthesized titanium carbide (TiC) and ex situ multi-walled carbon nanotube (MWCNT) as reinforcements using the liquid metallurgy route. The wear characteristics of the aluminum hybrid MMCs were analyzed under the synergistic effects of TiC and multi-walled CNT. Pin-on-disc wear setup was utilized for the experimental investigation where the hybrid composite is considered as the disc, and the traditional brake pad material is treated as the pin. The parameters, i.e., sliding distance, applied load, sliding velocity, and reinforcement content, are treated as inputs, whereas the wear-rate and coefficient of friction are considered output variables for the tribological experimentation. The influence of various input process parameters on the tribological behavior of the fabricated samples was investigated. The plastic deformation attained by the base alloy exhibited delamination, which indicates adhesive wear, whereas the composites exhibited abrasive nature as analyzed from the wear surface morphology. The wear debris was characterized by flake-sized, corrugated, and oxidized by the microstructural study.
‘Now I can train myself to be with death’: a phenomenological study with young doctors in care homes supported by a palliative care unit during the second wave of the pandemic in Italy
Authors: Moroni Matteo , Díaz Crescitelli Matías Eduardo , Capuccini Jenny , Pedroni Cristina , Bianco Mattia , Montanari Luigi , Ghirotto Luca 
Published: April 2023

ObjectiveDuring the second wave of the COVID-19 pandemic, one of the organisational strategies established by the Italian National Health System was the special units for continuity of care (SUCCs). In the province of Ravenna, those units enrolled novice doctors to care for elderly patients with COVID-19 in care homes (CHs). The local palliative care (PC) unit decided to offer consultations and support to them. This study aimed to comprehend the experience of young doctors who asked for consultations when facing, during their first early years of practice, complex situations.DesignWe conducted a qualitative study employing a phenomenological approach and in-depth interviews.ParticipantsWe involved 10 young doctors who worked in Italian SUCC during the pandemic and used a PC consultation support service.ResultsWhat describes our participants’ experience is related to four main themes: (1) reducing distances, (2) perceiving medical futility and improvising, (3) being supported to learn how to be with death and (4) narrowed timing to humanise care. The pandemic was, for our participants, a moment of reflection and critique on the skills acquired during the university course. It was a strong experience of human and professional growth that helped them reshape and deepen their role and skills, incorporating the approach of PC into their professional identity.ConclusionsIntegration between specialists and young doctors with an early entry into the workforce during the pandemic in CHs set out a ‘shift’ to a proactive and creative approach through a new awareness of professional and personal roles in doctor–patient relations. The continuity of care models should be rethought by integrating CHs and PC. Adequate PC training for young doctors (at pregraduate and postgraduate levels) can change doctors’ vision and daily practice in assisting patients at the end of life.
Physio-psycho-social interaction mechanism in dyadic health of young and middle-aged stroke survivors and their spousal caregivers: a longitudinal observational study protocol
Authors: Xiang Dandan , Zhang Zhen-xiang , Ge Song , Wang Wen na , Lin Bei-lei , Chen Su-yan , Guo Er-feng , Zhang Peng-bo , Liu Zhi-wei , Li Hui , Mei Yong-xia 
Published: April 2023

IntroductionIn recent years, stroke has become more common among young people. Stroke not only has a profound impact on patients’ health but also incurs stress and health threats to their caregivers, especially spousal caregivers. Moreover, the health of stroke survivors and their caregivers is interdependent. To our knowledge, no study has explored dyadic health of young and middle-aged stroke survivors and their spousal caregivers from physiological, psychological and social perspectives. Therefore, this proposed study aims to explore the mechanism of how physiological, psychological and social factors affect dyadic health of young and middle-aged stroke survivors and their spousal caregivers. The findings of this study will provide implications for developing interventions to improve dyadic health of this growing population.Methods and analysesWe will collect data from 57 dyads of young and middle-aged stroke survivors and their spousal caregivers during hospitalisation and at 1, 3, 6, 9 and 12 months after discharge. Questionnaires will be used to collect participants’ demographic information, stress, depression, anxiety, benefit finding, social support, mutuality and quality of life. The following physiological reactions will be collected at baseline, including interleukin 6, tumour necrosis factor-alpha and salivary cortisol.Ethics and disseminationThe study was approved by the ethics review committee of life sciences of Zhengzhou University (No. ZZUIRB2020-53). Prior to being enrolled in the study, participants will be given full and detailed information about the possible risks involved, the informed consent process, confidentiality, the study procedure and secure data storage. Participants will be guaranteed that they can withdraw from the study at any time without providing a reason or leading to any consequences. Both oral and written informed consent will be obtained from all participants. The findings of this proposed study will be disseminated through peer-reviewed journals and academic conferences.
Association between the volume of fluid resuscitation and mortality modified by disease severity in patients with sepsis in ICU: a retrospective cohort study
Authors: Zheng Rui , Jin Xinhao , Liao Weichao , Lin Ling 
Published: April 2023

ObjectiveThe important effect modifiers of high disease severity on the relationship between the different volumes of early fluid resuscitation and prognosis in septic patients are unknown. Thus, this study was designed to assess whether the efficacy of different volumes in the early fluid resuscitation treatment of sepsis is affected by disease severity.DesignRetrospective cohort study.SettingAdult intensive care unit (ICU) patients with sepsis from 2001 to 2012 in the MIMIC-III database.InterventionsThe intravenous fluid volume within 6 hours after the sepsis diagnosis serves as the primary exposure. The patients were divided into the standard (≥ 30 mL/kg) and restrict (<30 mL/kg) groups. Disease severity was defined by the sequential organ failure assessment (SOFA) score at ICU admission. Propensity score matching analysis was performed to ensure the robustness of our results.Primary and secondary outcome measuresThe primary endpoint of this study was 28-day mortality. Days without needing mechanical ventilation or vasopressor administration within 28-day of ICU admission serving as the secondary endpoint.ResultsIn total, 5154 consecutive individuals were identified in data analysis, 776 patients had a primary end-point event, 386 (49.68%) in the restrict group and 387 (49.81%) in the standard group. Compared with the restrict group, the standard group had higher 28-day mortality (adjusted HR, 1.32; 95% CI 1.03 to 1.70; p=0.03) in the subgroup with a sequential organ failure assessment (SOFA) score ≥10. By contrast, the risk of mortality reduction was modest in the subgroup with an SOFA score <10 (adjusted HR, 0.85; 95% CI 0.70 to 1.03; p=0.10). The effect of the interaction between the SOFA score and fluid resuscitation strategies on the 28-day mortality was significant (p=0.0035).ConclusionsHigh disease severity modifies the relationship between the volume of fluid resuscitation and mortality in patients with sepsis in the ICU; future studies investigating this interaction are warranted.
Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis
Authors: Wang Sidan , Tang Jiaoqi , Tan Yurong , Song Zhi , Qin Ling 
Published: April 2023

ObjectivesWe aimed to summarise the prevalence of atypical pathogens in patients with severe pneumonia to understand the prevalence of severe pneumonia caused by atypical pathogens, improve clinical decision-making and guide antibiotic use.DesignSystematic review and meta-analysis.Data sourcesPubMed, Embase, Web of Science and Cochrane Library were searched through November 2022.Eligibility criteriaEnglish language studies enrolled consecutive cases of patients diagnosed with severe pneumonia, with complete aetiological analysis.Data extraction and synthesisWe conducted literature retrieval on PubMed, Embase, Web of Science and The Cochrane Library to estimate the prevalence ofChlamydia,MycoplasmaandLegionellain patients with severe pneumonia. After double arcsine transformation of the data, a random-effects model was used for meta-analyses to calculate the pooled prevalence of each pathogen. Meta-regression analysis was also used to explore whether the region, different diagnostic method, study population, pneumonia categories or sample size were potential sources of heterogeneity.ResultsWe included 75 eligible studies with 18 379 cases of severe pneumonia. The overall prevalence of atypical pneumonia is 8.1% (95% CI 6.3% to 10.1%) In patients with severe pneumonia, the pooled estimated prevalence ofChlamydia,MycoplasmaandLegionellawas 1.8% (95% CI 1.0% to 2.9%), 2.8% (95% CI 1.7% to 4.3%) and 4.0% (95% CI 2.8% to 5.3%), respectively. We noted significant heterogeneity in all pooled assessments. Meta-regression showed that the pneumonia category potentially influenced the prevalence rate ofChlamydia. The mean age and the diagnostic method of pathogens were likely moderators for the prevalence ofMycoplasmaandLegionella, and contribute to the heterogeneity of their prevalence.ConclusionsIn severe pneumonia, atypical pathogens are notable causes, especiallyLegionella. The diagnostic method, regional difference, sample size and other factors contribute to the heterogeneity of prevalence. The estimated prevalence and relative heterogeneity factors can help with microbiological screening, clinical treatment and future research planning.PROSPERO registration numberCRD42022373950.
Investigating divergent thinking and creative ability in surgeons (IDEAS): a survey protocol
Authors: Thabane Alex , Busse Jason W , Sonnadara Ranil , Bhandari Mohit 
Published: April 2023

IntroductionA strong pipeline of creative ideas and individuals is critical if we are to tackle the complex healthcare challenges we will face in the 21st century. The field of creativity is severely underinvestigated in the context of surgery, and it is of interest to explore the level and nature of creativity in surgeons, across various specialties and backgrounds. Identifying the areas of surgery with strong and weak levels of creativity, as well as the predictors of high creativity among surgeons, may aid in the selection and training of future surgeons.Methods and analysisA convenience sample of surgeons from the Department of Surgery and McMaster University will be used for the recruitment of participants. The Abbreviated Torrance Test for Adults, a three-part test of divergent thinking ability, will be administered to measure the level and nature of creativity among surgeons. Descriptive analyses and multiple linear regression models are planned to synthesise the results of the survey and identify predictors of divergent thinking ability among surgeons.Ethics and disseminationEthics approval from the Hamilton Integrated Research Ethics Board was obtained. No harm is expected due to participation in this study. The results of this survey will be published in a peer-reviewed journal and disseminated through conferences and presentations at the regional, national and international levels.