bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of cutaneous graft‐versus‐host disease in a Singapore academic medical centre – A retrospective cohort study
Authors: Tan Wen Hao , Ho Aloysius , Kadir Hanis Abdul , Zin That Khaing , Jordan Hwang Chung Cheng , Lee Haur Yueh , Pang Shiu Ming , Yeo Yi Wei , Choo Karen Jui Lin , Oh Choon Chiat 
Published: January 2023

AbstractBackgroundCutaneous graft‐versus‐host disease (GVHD) is common in allogeneic haematopoietic stem cell transplantation. HLA mismatch is the most significant determinant of GVHD. Our study aimed to compare the incidence of cutaneous GVHD haploidentical (Haplo) and matched donors in an Asian population.MethodsRetrospective cohort study of the 2015–2019 bone marrow transplant registry was conducted in a transplant centre. We compared the incidence of cutaneous GVHD in Haplo with allogeneic matched unrelated donor (MUD) and matched–sibling donor (MSD) transplant recipients. Secondary objectives include acute and chronic GVHD incidence, dermatology referrals, and histological findings.ResultsOne hundred and seventy‐nine out of 203 cases were reviewed; 17 (9.5%) Haplo, 80 (44.7%) MUDs and 82 (45.8%) MSDs. The median follow‐up for Haplo, MUD and MSD was 15.2, 34.2 and 35.7 months, respectively. Haplo had a higher cumulative incidence of cutaneous GVHD than MUD and MSD (p = 0.053). Chronic GVHD was only reported in MSD. The most common histology was vacuolar interface changes (13 [44.8%]) with a wide range of onset post‐transplant (19–456 days).ConclusionsHaplo donors may have a higher GVHD incidence than MUD and MSD in our predominantly Asian cohort. This information may be helpful when counselling patients pre‐transplant. Further prospective studies are required.
Relational peace versus pacific primacy: Configuring US strategy for Asia's regional order
Authors: Jackson Van 
Published: January 2023

AbstractThis article challenges the presumption that American commitment to the greater Indo‐Pacific region has positive effects on regional stability. It argues that the degree to which America's strategic choices in Asia embrittle or consolidate peace depends on how they intersect with relational configurations of regional order. An accommodative strategy of restraint and mutual threat reduction offers the greatest stability with the least risk either when China's ties to a unified Asia are predatory or when Asia is fractured but China's ties to it are cooperative. A balance‐of‐power strategy offers the greatest stability and least risk when China's ties to a fractured Asia are confrontational or predatory. And an institutional strategy offers the greatest stability with the least risk when China enjoys broadly cooperative ties to Asia regardless of whether Asian states are unified or fractured. Crucially, a strategy of primacy or containment embrittles regional peace because it conflicts with every foreseeable configuration of relational order. America's role as a Pacific Power should adapt to local relational conditions if it is to serve the greater purpose of regional peace.
South Korea in the ASEAN‐centered regional network
Authors: Teo Sarah 
Published: January 2023

AbstractRelying on a networked perspective, this article argues that South Korea is an actor of relative importance in ASEAN's regional network, but it ultimately does not occupy a place that is more crucial than the association's other dialogue partners. In the context of ASEAN seeking to maintain its network power in an evolving Indo‐Pacific, South Korea has played a supportive role in ASEAN's pursuit of social access, brokerage links and minimizing its exit potential from the Indo‐Pacific network. South Korea's role, however, has been a comparably limited one rooted in specific functional areas and focused on certain ASEAN member states. While these efforts would certainly reinforce ASEAN's network power to some extent, the relatively thin network links between ASEAN and South Korea in other sectors suggest that there is little potential to expand cooperation beyond a functional and socioeconomic trajectory.
Multiple canopy opening effects on recruited saplings in a typhoon‐disturbed tropical rainforest, Taiwan
Authors: Chao Kuo‐Jung , Hsu Tien‐Yao , Lu Tain‐Chi , Song Guo‐Zhang Michael , Chao Wei‐Chun , Wu Chen‐Fa , Sheue Chiou‐Rong , Hsieh Chang‐Fu , Schupp Eugene W. 
Published: January 2023

AbstractTo investigate the influence of multiple canopy openings on the composition and diversity of recruited saplings in a forest frequently disturbed by typhoons. We conducted tree‐by‐tree censuses (diameter at breast height ≥ 1 cm) and mapped gaps (canopy height < 5 m) in 1993, 2000, 2008, and 2013 in a tropical mountain zonal foothill evergreen broad‐leaved forest in Nanjenshan Nature Reserve, Taiwan. We analyzed the composition and diversity of recruited saplings within a 2.1 ha plot (840 sampling quadrats (5 m × 5 m)) with variable numbers of canopy openings recorded during the study period. Composition of recruited saplings was dissimilar between quadrats that stayed opened and those that stayed closed throughout the study period (pairwise similarity estimates C02 = 0.52, 95% CI = 0.38–0.66). The quadrats under closed canopy had high diversity when weighting rare species (species richness), whereas quadrats with one or two gap opening records during the past 20 years had high diversity when weighting the abundance of species. Although canopy openings provided establishment conditions for saplings of some shade‐intolerant species, due to the nature of small gap size, such habitats do not favor the dominance of shade‐intolerant species. Even in a frequently disturbed forest, species composition and richness of recruited saplings were mainly contributed by shade‐tolerant species. Although multiple canopy openings facilitated the establishment of shade‐intolerant species, species diversity in the study forests is possibly mainly mediated by coexistence mechanisms of those shade‐tolerant species rather than light‐gap‐related species strategies.
Patient education information material assessment criteria: A scoping review
Authors: Ahmadzadeh Khadijeh , Bahrami Masoud , Zare‐Farashbandi Firoozeh , Adibi Payman , Boroumand Mohammad Ali , Rahimi Alireza 
Published: January 2023

AbstractBackgroundPatient education information material (PEIM) is an essential component of patient education programs in increasing patients' ability to cope with their diseases. Therefore, it is essential to consider the criteria that will be used to prepare and evaluate these resources.ObjectiveThis paper aims to identify these criteria and recognize the tools or methods used to evaluate them.MethodsNational and international databases and indexing banks, including PubMed, Scopus, Web of Science, ProQuest, the Cochrane Library, Magiran, SID and ISC, were searched for this review. Original or review articles, theses, short surveys, and conference papers published between January 1990 and June 2022 were included.ResultsOverall, 4688 documents were retrieved, of which 298 documents met the inclusion criteria. The criteria were grouped into 24 overarching criteria. The most frequently used criteria were readability, quality, suitability, comprehensibility and understandability.ConclusionThis review has provided empirical evidence to identify criteria, tools, techniques or methods for developing or evaluating a PEIM. The authors suggest that developing a comprehensive tool based on these findings is critical for evaluating the overall efficiency of PEIM using effective criteria.
Diagnostic test accuracy of D‐dimer with or without a clinical decision rule in peripartum patients with suspected venous thromboembolism: A systematic review and meta‐analysis
Authors: Oh Jeong S. , Jayasimhan Dilip , Sithamparanathan Sasiharan 
Published: January 2023

AbstractBackgroundPregnancy and the peripartum period is a hypercoagulable state increasing the risk of venous thromboembolism (VTE). There may be a role in utilising D‐dimer in the peripartum setting.AimsThe purpose of this review was to summarise the latest evidence regarding the diagnostic accuracy of D‐dimer in the peripartum setting with or without the addition of clinical decision rules.MethodsWe searched PubMed and CENTRAL databases to identify articles that included studies of women who had suspected VTE, underwent a D‐dimer index test to rule out VTE and where radiological imaging or clinical follow‐up, to a minimum of 30 days, was used as the reference standard.ResultsWe included 11 studies in the systematic review and meta‐analysis. The log diagnostic odds ratio (DOR) for identifying VTE using D‐dimer was 1.56 (95% confidence interval (CI) 0.59–2.52). The pooled sensitivity was 87% (95% CI 76.8–93%), specificity was 63.2% (95% CI 47.1–76.7%), and the area under receiver operator characteristic (ROC) curves was 0.76. We included four studies evaluating D‐dimer combined with YEARS to detect VTE. The log DOR for identifying VTE using D‐dimer combined with YEARS was 1.13 (95% CI 0.005–2.25). The pooled sensitivity was 89.8% (95% CI 60.2–98.1%), specificity was 65.7% (95% CI 54.7–75.2%) and the area under ROC for studies included with the YEARS clinical decision rule was 0.49.ConclusionThis review highlighted that D‐dimer use in the peripartum period for detection of VTE had a high sensitivity and high DOR but a poor area under ROC, which may limit its use in clinical practice.
CLEFMA induces intrinsic and extrinsic apoptotic pathways through ERK1/2 and p38 signalling in uterine cervical cancer cells
Authors: Lee Chung‐Yuan , Hsiao Yi‐Hsuan , Chen Pei‐Ni , Wu Heng‐Hsiung , Lu Chih‐Yun , Yang Shun‐Fa , Wang Po‐Hui 
Published: January 2023

AbstractAlthough concurrent chemoradiotherapy is the cornerstone of treatment for locally advanced or recurrent uterine cervical cancer, treatment fails at a high rate. Therefore, the development of novel targeting agents is critical. This study investigated the action of CLEFMA, a potent, synthetic curcumin derivative, on cervical cancer cells and its mechanism of action. We found that CLEFMA negatively regulated the viability of cervical cancer cells, involving induction of cell apoptosis. Cleaved caspase‐3, cleaved poly(adenosine diphosphate‐ribose) polymerase, cleaved caspase‐8, and cleaved caspase‐9 expression were increased by treatment with CLEFMA. After U0126 (ERK1/2 inhibitor) and SB203580 (p38 inhibitor) were applied as cotreatment with CLEFMA, the expression of cleaved caspase‐8, ‐9, and ‐3 was reduced significantly. In conclusion, CLEFMA activates both extrinsic and intrinsic apoptotic pathways through ERK1/2 and p38 signal transduction in cervical cancer cells.
Reproductive isolating mechanisms contributing to asymmetric hybridization in Killifishes (Fundulus spp.)
Authors: MacPherson Nathalie , Champion Chloe P. , Weir Laura K. , Dalziel Anne C. 
Published: January 2023

AbstractWhen species hybridize, one F1 hybrid cross type often predominates. Such asymmetry can arise from differences in a variety of reproductive barriers, but the relative roles and concordance of pre‐mating, post‐mating prezygotic, and post‐zygotic barriers in producing these biases in natural animal populations have not been widely investigated. Here, we study a population of predominantly F1 hybrids between two killifish species (Fundulus heteroclitus and F. diaphanus) in which >95% of F1 hybrids have F. diaphanus mothers and F. heteroclitus fathers (D♀ × H♂). To determine why F. heteroclitus × F. diaphanus F1 hybrids (H♀ × D♂) are so rare, we tested for asymmetry in pre‐mating reproductive barriers (female preference and male aggression) at a common salinity (10 ppt) and post‐mating, pre‐zygotic (fertilization success) and post‐zygotic (embryonic development time and hatching success) reproductive barriers at a range of ecologically relevant salinities (0, 5, 10, and 15 ppt). We found that F. heteroclitus females preferred conspecific males, whereas F. diaphanus females did not, matching the observed cross bias in the wild. Naturally rare H♀ × D♂ crosses also had lower fertilization success than all other cross types, and a lower hatching success than the prevalent D♀ × H♂ crosses at the salinity found in the hybrid zone centre (10 ppt). Furthermore, the naturally predominant D♀ × H♂ crosses had a higher hatching success than F. diaphanus crosses at 10 ppt, which may further increase their relative abundance. The present study suggests that a combination of incomplete mating, post‐mating pre‐zygotic and post‐zygotic reproductive isolating mechanisms act in concert to produce hybrid asymmetry in this system.
Ionized hypercalcemia in 238 cats from a referral hospital population (2009‐2019)
Authors: Broughton Sophie E. , O'Neill Dan G. , Syme Harriet M. , Geddes Rebecca F. 
Published: January 2023

AbstractBackgroundIonized calcium concentration ([iCa]) is more sensitive for detecting calcium disturbances than serum total calcium concentration but literature on ionized hypercalcemia in cats is limited. Urolithiasis is a possible adverse consequence of hypercalcemia.Hypothesis/ObjectivesTo describe clinical details of diagnoses associated with ionized hypercalcemia in cats and association with urolithiasis.AnimalsCats (238) seen between 2009 and 2019 at a referral hospital with [iCa] above the normal reference interval.MethodsObservational cross‐sectional study. Signalment, serum biochemical and imaging findings were reviewed for cats with ionized hypercalcemia considered to be clinically relevant (>1.41 mmol/L). Data were summarized by cause of hypercalcemia (i.e., diagnosis).ResultsDiagnoses for the 238 cats with [iCa] >1.41 mmol/L included: acute kidney injury (AKI; 13%), malignancy‐associated (10.1%), idiopathic hypercalcemia (IHC; 10.1%), chronic kidney disease/renal diet‐associated (8.4%), iatrogenic (5.5%), primary hyperparathyroidism (2.1%), vitamin D toxicity (2.1%) and granulomatous disease (1.7%). In 112 cases (47.1%), no cause for ionized hypercalcemia could be determined (n = 95), hypercalcemia was transient (n = 12), or the cat was juvenile (<1 year; n = 5). Urolithiasis was identified in 83.3% of AKI, 72.7% of iatrogenic, 61.1% of CKD/renal diet‐associated and 50% of IHC cases that were imaged (<50% for other diagnoses). Diagnoses with a high proportion of concurrent total hypercalcemia included primary hyperparathyroidism (100%), vitamin D toxicity (100%), malignancy‐associated (71.4%), granulomatous disease (66.7%) and IHC (65.2%).Conclusions and Clinical ImportanceIonized hypercalcemia was most commonly associated with kidney diseases, neoplasia or IHC. The proportion of urolithiasis cases varied by diagnosis.
Surgical Treatment of Adams Type IV Anterolateral Fracture of the Ulna Coronoid Process
Authors: Zhang Bo , Liu Lintao , Liu Junyang , Wang Guangyu , Han Lei , Tian Xu , Dong Jingming 
Published: January 2023

ObjectiveAnterolateral coronal fractures are so rare that the mechanism of injury, the type of combined fracture and ligament injury, and the optimal treatment are unknown. To study the outcome of surgical treatments for anterolateral (AL) fracture of the ulna coronoid process (Adams Type IV) and summarize the characteristics of this type of fracture and to guide clinical applications.MethodsFrom February 2015 to April 2021, 32 patients were included in the study. All patients had standard radiography with anteroposterior and lateral views, computed tomography, and intraoperative fluoroscopy. All patients were treated surgically. Surgery‐related information, including surgical approach, operation duration, blood loss, and repairing the lateral collateral ligament and the medial collateral ligament integrity, were recorded. The patient's clinical details, such as the final range of motion (ROM), the Broberg–Morrey scores and the visual analogue scale (VAS) at the last follow‐up, were described. The chi‐square test or Fisher's exact test was used for statistical analysis.ResultsWe divided patients into two groups according to the anterolateral coronoid fracture morphology. In the intact group, 20 patients with an intact anterolateral coronoid fracture fragment. In the comminuted group, 12 patients with comminuted anterolateral coronoid fracture fragments extended the less sigmoid notch of the ulna. There was no difference in age, sex, total incision length, follow‐up duration, and recovery with rehabilitation among the two groups (all Ps >0.05). The other follow‐up outcomes, such as elbow ROM (Flexion, Extension, Posterior rotation, Anterior rotation), VAS score, or Broberg–Morrey scores, were not different between the two groups (all Ps >0.05). Both groups achieved relatively satisfactory clinical outcomes, and the Broberg–Morrey score and index excellence rate reached 84.38%. There is a statistical difference in the history of elbow dislocation (P = 0.017), radial head fracture type (P = 0.041), operation duration (P = 0.014) and blood loss at operation (P = 0.029) between the two groups. Cannulated screws, anchors, and sutures were used as point fixation in the coronoid process of the ulna. There was a statistical difference between the two groups in the choice of internal fixation (P = 0.020).ConclusionsFor anterolateral ulnar coronoid fractures with different degrees of comminution, effective and reliable surgical treatment can achieve better results and fewer complications.
Pseudo repetitive non‐reentrant ventriculoatrial synchrony: Current challenges
Authors: Gjermeni Erind , Doering Michael , Hindricks Gerhard , Bode Kerstin 
Published: January 2023

AbstractBackgroundWe recently described a novel pacemaker‐mediated arrhythmia in Abbott cardiac implantable electronic devices (CIED), called pseudo‐RNRVAS, that mimics repetitive non‐reentrant ventriculoatrial synchrony (RNRVAS), but can appear in patients with ventriculoatrial (VA) block. It is caused by sinus‐p‐waves, trapped in the post‐ventricular atrial refractory period (PVARP), which mimic VA conduction. The p‐waves are followed by atrial pacing during the myocardial refractory time, which can trigger atrial fibrillation (AF). Pseudo‐RNRVAS and RNRVAS are probably more common than appreciated, but the recognition and differentiation of the two can be challenging because most CIEDs do not recognize and store them.ObjectiveWe illustrate practical challenges in the assessment of Pseudo‐RNRVAS and provide programming options that proved safe and effective for preventing Pseudo‐RNRVAS and reducing the risk for typical RNRVAS.Methods and ResultsWe illustrate in 10 patients the characteristics of Pseudo‐RNRVAS and their treatment. The outcome regarding the recurrence of pseudo‐RNRVAS after 6 months of follow‐up was collected. Inappropriate atrial pacing during pseudo‐RNRVAS resulted in AF in six patients. After shortening the PVARP in nine, inactivation/reduction of rate response in four, and reduction of the basic pacing rate in one patient, pseudo‐RNRVAS was avoided in eight patients and reduced in one. In one patient AF became permanent.ConclusionsPseudo‐RNRVAS is a pacemaker‐mediated arrhythmia that can appear in patients without VA conduction and may lead to AF. The suggested adjustments of pacing parameters were safe and effective in preventing the arrhythmia.
Populist things. A study on the materiality of political ideas
Authors: Carreira da Silva Filipe , Rogenhofer Julius 
Published: January 2023

AbstractIs there such thing as a populist thing? This article tries to answer this question by comparing two iconic populist objects: the Make America Great Again (MAGA) cap and the yellow vest. Despite their centrality to populist politics, there is remarkably little systematic examination of these objects' populist affordances, let alone a comparative study. We propose to address this lacuna by performing a pragmatic analysis of each object's role in the populist politics of the United States and France, respectively. Our comparison uncovers two findings, which, in turn, help us answer our research question. First, our study of the MAGA cap reveals how nationalism and populism can be combined into a powerful political message. Second, the yellow vest exemplifies how populism functions on its own that is, as a way of doing politics that is centred on feelings of resentment. Either in conjunction with other political phenomena (e.g., nationalism) or by itself, populism emerges from our analysis as a logic of action that involves both linguistic claims and physical objects. Things, in this reading, are surprisingly central to how populism operates.
Evaluation of outcome associated with feline trauma: A Veterinary Committee on Trauma registry study
Authors: Gregory Carly W. , Davros Akaterina M. , Cockrell Darren M. , Hall Kelly E. 
Published: January 2023

AbstractObjectiveTo evaluate outcome (survival to discharge) among trauma types (blunt, penetrating, both) in cats. Secondary objectives were to evaluate for associations between trauma type, injury severity, and the diagnostics and interventions selected by primary clinicians.DesignRetrospective evaluation of veterinary trauma registry data.SettingVeterinary Committee on Trauma (VetCOT) veterinary trauma centers (VTCs).AnimalsA total of 3895 feline trauma patients entered in the VetCOT trauma registry from April 1, 2017 to December 31, 2019.InterventionsData collected included patient demographics, trauma type, Abdominal Fluid Score (AFS), Animal Trauma Triage (ATT) score, surgical intervention, glide sign on Thoracic Focused Assessment with Sonography for Trauma, Triage, and Tracking (TFAST), pleural effusion on TFAST, modified Glasgow Coma Scale (mGCS), and outcome (survival to discharge).Measurements and Main ResultsData from 3895 cats were collected over a 30‐month period. Incidence of trauma types was as follows: blunt, 58% (95% confidence interval [CI]: 56%–59%); penetrating, 35% (95% CI: 34%–37%); and combination, 7.4% (95% CI: 6.7%–8.3%). Differences in survival incidence among the trauma types were identified: blunt, 80% (95% CI: 78%–81%); penetrating, 90% (95% CI: 89%–92%); and combined, 68% (95% CI: 63%–74%) (P < 0.01). Cats in the penetrating trauma group had the lowest proportion of severe injuries (6%) and highest proportion of mGCS of 18 (89%); cats with combined trauma had the highest proportion of severe injuries (26%) and lowest proportion of mGCS of 18 (63%). Point‐of‐care ultrasound and surgery were not performed in the majority of cases. When surgery was performed, the majority of blunt cases’ procedures occurred in the operating room (79%), and the majority of penetrating cases’ procedures were performed in the emergency room (81%).ConclusionsCats suffering from penetrating trauma had the best outcome (survival), lower ATT scores, and higher mGCS overall. Cats that sustained a component of blunt trauma had a lower survival rate, higher ATT scores, and the highest proportion of mGCS <18.