bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained force production by the jaw‐adductor muscles of a megalophagous frog, Ceratophrys cranwelli
Authors: Powell Anthony R. , Deban Stephen M. , Lappin A. Kristopher 
Published: March 2023

AbstractMost frogs have weak jaws that play a relatively minor role in tongue‐mediated prey capture. Horned frogs (Ceratophrys spp.), however, follow the projection of a large tongue with a vice‐like grip of their jaws to hold and immobilize prey. Prey include relatively large vertebrates, which they may restrain for minutes to possibly hours. High endurance behaviors, such as prolonged biting, require that muscles be capable of sustained force production. The feeding behavior of Ceratophrys suggests that their jaw‐adductor muscles may be capable of powering sustained bites for long periods. We examined the capacity for sustained bite force by conducting an in situ experiment during which we measured bite force while bilaterally and supramaximally stimulating the jaw‐adductor muscles of euthanized Cranwell's horned frogs (C. cranwelli). Muscles were stimulated for at least 60 min with a series of tetanic trains, with one experiment lasting over 6 h. We found that a significant sustained force develops during the first few minutes of the experiment, and this force is present between tetanic trains when the muscles are not being stimulated. The sustained force persists long after tetanic forces are barely detectable. The observed sustained force phenomenon parallels that observed for the jaw‐adductor muscles of alligator lizards (Elgaria), another animal capable of sustained biting. The ability to bite with sustained and significant force by C. cranwelli may be facilitated by a configuration of different muscle fiber types, such as slow tonic fibers, as well as specializations in the muscle fibers that mitigate the effects of fatigue.
The diversity in the clinical features of children hospitalized with COVID‐19 during the nonvariant, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variant periods of SARS CoV‐2: Caution for neurological symptoms in Omicron variant
Authors: Sahin Aslıhan , Karadag‐Oncel Eda , Buyuksen Osman , Ekemen‐Keles Yildiz , Ustundag Gulnihan , Elvan‐Tuz Aysegul , Tasar Selin , Didinmez‐Taskirdi Elif , Baykan Muge , Kara‐Aksay Ahu , Yilmaz Nisel , Olgac‐Dundar Nihal , Yilmaz Dilek 
Published: March 2023

AbstractSince the COVID‐19 pandemic began, various severe acute respiratory syndrome coronavirus 2 variants have been identified with different characteristics than the nonvariant strain. We retrospectively evaluated the demographic and clinical differences in the cohort of hospitalized COVID‐19 children (1 month–18 years old) between March 11, 2020, and September 31, 2022, by the time the variants identified in our country predominate. Bonferroni post hoc analysis was performed to compare the differences between the periods. Of the 283 children in this study, 142 (50.2%) were females. The median age was 36 (interquartile range [IQR]: 7–132) months. Sixty‐three (22.2%) patients were hospitalized in the nonvariant period, 24 (8.5%) in the Alpha period, 93 (32.9%) in the Delta period, and 103 (36.4%) in the Omicron period. Fever was the most common symptom in all groups, with no statistically significant differences (p = 0.25). In the Omicron period, respiratory and gastrointestinal symptoms decreased, and neurological symptoms increased significantly compared to other periods: [respiratory symptoms; nonvariant (65.1%) vs. Omicron (41.7%), (p = 0.024)], [gastrointestinal symptoms; Delta (41.9%) vs. Omicron (22.3%), (p = 0.018), [neurological symptoms; Delta (14.5%) vs. Omicron (31.1%), (p = 0.03]. Altered mental status and seizures were more common during the Omicron period compared to the pre‐Omicron (nonvariant, Alpha, and Delta) period (p = 0.017 and p = 0.005, respectively). Although the main symptoms in children with COVID‐19 were fever and respiratory symptoms, an increase in severe neurological manifestations was seen throughout the Omicron variant period.
Impact of the introduction of marketplace channel on e‐tailer's logistics service strategy
Authors: Chen Lin , Dong Ting , Nan Guofang , Xiao Qinzi , Xu Meng , Ming Junren 
Published: March 2023

AbstractWe recently observe that some giant e‐tailers (e.g., Amazon and JD.com) introduce marketplace channels by allowing third‐party sellers to sell products through their platforms. Logistics service acts as a vital role in the operation of online platforms. In practice, the platform can outsource logistics service to third‐party logistics providers (named as a third‐party logistics strategy) or establish a self‐run logistics network to distribute products (named as a self‐run logistics strategy). This paper investigates the e‐tailer's logistics service strategy in the presence of the marketplace channel's introduction. We reveal that the cost of logistics service plays a major role in determining the optimal logistics strategy. The self‐run logistics strategy provides a low logistics service cost to the platform, which results in a higher consumer surplus in comparison with the third‐party logistics strategy. Further, we find that when the logistics service cost is low, the platform prefers to establish self‐run logistics in the presence of the marketplace channel. Finally, our results show that under the third‐party logistics strategy, the platform benefits from the marketplace channel in the presence of an intermediate commission fee and a low discount factor. Based on game‐theoretic models, some managerial insights are suggested for online retailers to choose the optimal logistics service strategy in the presence of introducing the marketplace channel.
Natural course of fat necrosis after deep inferior epigastric perforator flap‐based breast reconstruction: Evaluation based on ultrasound examination
Authors: Moon JeeHyun , Park Hae‐Yeon , Lee Kyeong‐Tae , Mun Goo‐Hyun 
Published: March 2023

AbstractBackgroundFat necrosis, often developing following deep inferior epigastric perforator (DIEP) flap‐based breast reconstruction, is not a negligible complication. This study aimed to conduct a longitudinal assessment of the clinical course of fat necrosis in breast reconstruction with DIEP flap.MethodsAmong patients undergoing immediate DIEP flap‐based breast reconstruction between 2009 and 2017, those who developed fat necrosis on ultrasonographic examination and did not undergo surgical intervention for the lesion were reviewed. Changes in lesion size over time were assessed based on regular ultrasound examinations.ResultsA total of 37 cases were analyzed, with a mean follow‐up of 52.6 months (range, 19–114). Their mean age was 45.8 years, and the mean body mass index was 23.4 kg/m2. Of these, 21 lesions had disappeared over time. The mean time from detection to the disappearance was 30.4 months. The remaining 16 lesions did not disappear and persisted for a median follow‐up of 43.5 months. Compared with the lesions that persisted, those that disappeared were significantly smaller in initial size (p = 0.040) and had a lower inset ratio of the harvested flap (p = 0.006). The optimal cutoff value for the initial size for disappearance was ≤1.97 cm. Among the lesions >1.97 cm in size, 6 (35.3%) of 17 lesions disappeared, whereas in those ≤1.97 cm, 15 (75.0%) of 20 disappeared over time, with a significant difference (p = 0.041).ConclusionThe natural course of fat necrosis that develops following the DIEP flap may differ according to its initial size.
Tri‐band bandpass filter designed by a fast hybrid approach
Authors: Wu Rihan , He Junling , Tang Xiaohong , Cai Zongqi , Xiao Likang , Xiao Fei 
Published: March 2023

AbstractMultiband bandpass filter is a key component in multistandard wireless communication system. This paper proposes a novel tri‐band bandpass filter (TB‐BPF) which consists of two mesh‐type multimode resonators (MT‐MMR) and two stub‐loaded U‐type feedlines. The MT‐MMR is formed by parallel connecting two open‐end stubs and one mesh‐type structure. Such specific configuration is featured by four inherent transmission zeros. The in‐depth analysis on the generation mechanism of the transmission zeros is made, and then a fast hybrid approach is developed for design procedure. Some explicit design equations are presented for fast determining initial values of some key parameters, and then further optimized by using a constraint condition, which effectively accelerate design process. For verification, an example of the TB‐BPF was designed fabricated and measured. Its center frequencies are at 3.16, 4.27, and 5.70 GHz, respectively. Six transmission zeros are generated for sharp frequency selectivity, and are at 1.46, 3.58, 3.86, 4.73, 5.51, and 7.18 GHz, respectively. Its size is about 0.59 × 0.19 λg2.
A spectrally accurate time ‐ space pseudospectral method for viscous Burgers' equation
Authors: Mittal A. K. , Balyan L. K. , Sharma K. K. 
Published: March 2023

AbstractThe aim of the paper is to develop and analyze a spectrally accurate pseudospectral method in time and space to find the approximate solution of the viscous Burgers' equation. The method is employed in time and space both at Chebyshev‐ Gauss‐ Lobbato (CGL) points. The approximate solution is represented in terms of basis functions. The spectral coefficients are found in such a way that the residual becomes minimum. The given problem is reduced to a system of nonlinear algebraic equations, which is solved by Newton‐Raphson's method. Error estimates for interpolating polynomials are derived. The computational experiments are carried out to corroborate the theoretical results and to compare the present method with existing methods in the literature.
Gpr75‐deficient mice are protected from high‐fat diet–induced obesity
Authors: Hossain Sakib , Gilani Ankit , Pascale Jonathan , Villegas Elizabeth , Diegisser Danielle , Agostinucci Kevin , Kulaprathazhe Melissa‐Maria , Dirice Ercument , Garcia Victor , Schwartzman Michal Laniado 
Published: March 2023

AbstractObjectiveG‐protein coupled receptor 75 (GPR75) has been identified as the high‐affinity receptor of 20‐hydroxyeicosatetraenoic acid (20‐HETE), a vasoactive and proinflammatory lipid, and mice overproducing 20‐HETE have been shown to develop insulin resistance when fed a high‐fat diet (HFD), which was prevented by a 20‐HETE receptor blocker. Simultaneously, a large‐scale exome sequencing of 640,000 subjects identified an association between loss‐of‐function GPR75 variants and protection against obesity.MethodsWild‐type (WT) and Gpr75‐deficient mice were placed on HFD for 14 weeks, and their obesity phenotype was examined.ResultsMale and female Gpr75 null (knockout [KO]) and heterozygous mice gained less weight than WT mice when placed on HFD. KO mice maintained the same level of energy expenditure during HFD feeding, whereas WT mice showed a significant reduction in energy expenditure. Diet‐driven adiposity and adipocyte hypertrophy were greatly lessened in Gpr75‐deficient mice. HFD‐fed KO mice did not develop insulin resistance. Adipose tissue from Gpr75‐deficient mice had increased expression of thermogenic genes and decreased levels of inflammatory markers. Moreover, insulin signaling, which was impaired in HFD‐fed WT mice, was unchanged in KO mice.ConclusionsThese findings suggest that GPR75 is an important player in the control of metabolism and glucose homeostasis and a likely novel therapeutic target to combat obesity‐driven metabolic disorders.image
Effect of continuous positive airway pressure on atrial remodeling and diastolic dysfunction of patients with obstructive sleep apnea and metabolic syndrome: a randomized study
Authors: Macedo Thiago Andrade , Giampá Sara Q. C. , Furlan Sofia F. , Freitas Lunara S. , Lebkuchen Adriana , Cardozo Karina H. M. , Carvalho Valdemir M. , Martins Franco C. , Mendonça Tiago , Bortolotto Luiz A. , Lorenzi‐Filho Geraldo , Drager Luciano F. 
Published: March 2023

AbstractObjectiveThe aim of this study was to evaluate the role of obstructive sleep apnea (OSA) treatment on heart remodeling and diastolic dysfunction in patients with metabolic syndrome (MS).MethodsThis study is a prespecified analysis of a randomized placebo‐controlled trial that enrolled patients with a recent diagnosis of MS and moderate‐to‐severe OSA to undergo continuous positive airway pressure (CPAP) or nasal dilators (placebo) for 6 months. Patients were invited to perform a transthoracic echocardiogram by a single investigator blinded to treatment assignment.ResultsA total of 99 (79% men; mean [SD], age: 48 [9] years; BMI: 33 [4] kg/m2) completed the study. At follow‐up, in the placebo group, patients had a significant increase in atrial diameter: from 39.5 (37.0‐43.0) mm to 40.5 (39.0‐44.8) mm (p = 0.003). CPAP prevented atrial enlargement: from 40.0 (38.0‐44.0) to 40.0 (39.0‐45.0) mm (p = 0.194). In patients with diastolic dysfunction at baseline, almost half had diastolic dysfunction reversibility with CPAP (in comparison with only two patients in the placebo group, p = 0.039). In the regression analysis, the chance of diastolic dysfunction reversibility by CPAP was 6.8‐fold (95% CI: 1.48‐50.26, p = 0.025) compared with placebo.ConclusionsIn patients with MS and OSA, 6 months of CPAP therapy prevented atrial remodeling and increased the chance of diastolic dysfunction reversibility.
New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes
Authors: Abdelmoniem Amr M. , Ramadan Muhammed A. , Ghozlan Said A. S. , Butenschön Holger , Abdelhamid Ismail A. 
Published: March 2023

AbstractNew Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[a]anthracenes, Tetraazaindeno[5,4‐b]fluorenes, and Oxatetraazacyclopenta[m]tetraphenes (H. Butenschön, I. A. Abdelhamid et al.) #OpenAccessMulticomponent reactions (MCRs) are envisaged as an entry point for the synthesis of heterocyclic compounds with interesting biological activities. An efficient approach to annelated tetra(hexa)azacyclopenta[a]anthracenes, tetraazaindeno[5,4‐b]fluorenes, and oxatetraazacyclopenta[m]tetraphene was accomplished using a three‐component reaction involving 7‐amino‐2‐methyl‐3‐phenylpyrazolo[1,5‐a]pyrimidin‐5‐one with aromatic aldehydes and the corresponding active 1,3‐dicarbonyl compounds (namely, dimedone, 1,3‐dimethylbarbituric acid, 1,3‐indanedione, and 4‐hydroxycoumarine). The reactions were conducted in glacial acetic acid at reflux for 5 h to give the desired products in good yields (62–83 %). The chemical constitutions of all new products were confirmed spectroscopically.
Translation and Validation of the Thai Version of the Nasal Obstruction Symptom Evaluation (NOSE) Scale
Authors: Prasertwit Kanokpon , Tanjararak Kangsadarn , Tangbumrungtham Navarat , Emasithi Alongkot , Roongpuvapaht Boonsam 
Published: March 2023

AbstractObjectiveThe Nasal Obstruction Symptom Evaluation (NOSE) was developed to evaluate subjective outcomes of patients with deviated nasal septum and symptomatic nasal obstruction. Considering the differences in individuals' cultural, cross‐cultural translation, adaptation, and validation of the instrument are necessary. The current study aimed to translate and validate the Thai version of the NOSE Questionnaire for patients with nasal septum deviation.Study DesignA single‐center prospective instrument validation study.SettingThai tertiary referral center.MethodsThe study was conducted to translate and adapt the original English version of the NOSE to Thai. After translating, psychometric testing was conducted. The primary outcomes were validity (content, construct, and discriminant), reproducibility (test‐retest procedure), and internal consistency (reliability). A total of 105 participants, of which 46 were patients with nasal airway obstruction and 59 were healthy asymptomatic volunteers, were enrolled in this study.ResultsThe Thai‐NOSE was found to be adequate for all tested psychometric properties with high internal consistency (Cronbach's α = .942), and to discriminate accurately between patients and healthy controls. The interitem and item‐total correlations indicated a related construct among all items. A high level of reproducibility of the questionnaire was obtained in the test‐retest procedure for each item (γ = 0.898). The initial test and retest scores indicated adequate reproducibility.ConclusionThe Thai‐NOSE questionnaire is a reliable instrument with appropriate psychometric properties for assessing the severity and impact of nasal airway obstruction in patients with nasal septum deviation.
Evaluation of the Impact of Optical Coherence Tomography on Pediatrician Otologic Examination Judgment
Authors: Teague Malinda S. , Nolan Ryan M. 
Published: March 2023

AbstractAccurate diagnosis of otitis media is imperative to judicious antibiotic prescription. Visualization of the tympanic membrane and accurate identification of middle ear effusion with standard otoscopy is inherently challenging in pediatrics, especially in the youngest children who are most at risk for otitis media. With the average diagnostic accuracy among primary care physicians of 50% and accurate identification of normal tympanic membrane versus acute otitis media versus otitis media with effusion ranging from 30% to 84% among pediatricians, there is great opportunity for diagnostic improvement and decreasing unnecessary antibiotic use. In a 96‐pediatrician‐blinded otoscopy diagnosis quiz, addition of optical coherence tomography, a novel depth‐imaging technology, resulted in a 32% improvement in fluid identification, and 21% increase in diagnostic accuracy. This study suggests that the clinical use of this technology promises to improve diagnostic accuracy and antibiotic stewardship in pediatrics.
Insight into peculiar adhesion of cells to plasma‐chemically prepared multifunctional “amino‐glue” surfaces
Authors: Buchtelová Martina , Blahová Lucie , Nečas David , Křížková Petra , Bartošíková Jana , Medalová Jiřina , Kolská Zdeňka , Hegemann Dirk , Zajíčková Lenka 
Published: March 2023

AbstractPlasma polymers (PPs) can easily modify material surfaces to improve their bio‐applicability due to match‐made surface‐free energy and functionality. However, cell adhesion to PPs typically composed of various functional groups has not yet been fully understood. We explain the origin of strong resistance to trypsin treatment previously noted for nonendothelial cells on amine PPs. It is caused mainly by nonspecific adhesion of negatively charged parts of transmembrane proteins to the positively charged amine PP surface, enabled by thin glycocalyx. However, endothelial cells are bound primarily by their thick, negatively charged glycocalyx and sporadically by integrins in kinetic traps, both cleaved by trypsin. Cell scratching by atomic force microscopy tip confirmed the correlation of trypsin resistance to the strength of cell adhesion.
Obstructive sleep apnea screening in children with asthma
Authors: Sowho Mudiaga O. , Koehl Rachelle , Shade Rebecca , Judge Eliza , Woo Han , Wu Tianshi David , Brigham Emily P. , Hansel Nadia N. , Tversky Jody , Sterni Laura M. , McCormack Meredith C. 
Published: March 2023

AbstractRationaleObstructive sleep apnea is highly prevalent in children with asthma, particularly in obese children. The sleep‐related breathing disorder screening questionnaire has low screening accuracy for obstructive sleep apnea in children with asthma. Our goal was to identify the questions on the sleep‐related breathing disorder survey associated with obstructive sleep apnea in children with asthma.MethodsParticipants completed the survey, underwent polysomnography and their body mass index z‐score was measured. Participants with survey scores above 0.33 were considered high risk for obstructive sleep apnea and those with an apnea–hypopnea index ≥ 2 events/h classified as having obstructive sleep apnea. Logistic regression was used to examine the association of each survey question and obstructive sleep apnea. Positive and negative predictive values were calculated to estimate screening accuracy.ResultsThe prevalence of obstructive sleep apnea was 40% in our sample (n = 136). Loud snoring, morning dry mouth, and being overweight were the survey questions associated with obstructive sleep apnea. The composite survey score obtained from all 22 questions had positive and negative predictive values of 51.0% and 65.5%, while the combined model of loud snoring, morning dry mouth, and being overweight had positive and negative predictive values of 60.3% and 77.6%. On the other hand, the body mass index z‐score alone had positive and negative predictive values of 76.3% and 72.2%.ConclusionsThe body mass index z‐score is useful for obstructive sleep apnea screening in children with asthma and should be applied routinely given its simplicity and concerns that obstructive sleep apnea may contribute to asthma morbidity.
Filtering‐based concurrent learning adaptive attitude tracking control of rigid spacecraft with inertia parameter identification
Authors: Long Jiang , Guo Yangming , Liu Zun , Wang Wei 
Published: March 2023

SummaryThis paper investigates the attitude tracking control problem of rigid spacecraft with inertia parameter identification. Based on the relative attitude and angular velocity error dynamics, a basic adaptive backstepping based attitude tracking control scheme is firstly designed such that asymptotic attitude tracking can be achieved. However, the parameter identification error cannot decay to zero if the persistent excitation (PE) condition is not satisfied. To solve this issue, a filtering‐based concurrent learning adaptive backstepping control scheme is then proposed, by incorporating torque filtering technique with concurrent learning technique. A more mild rank condition, which consists of some collectable historical data, is provided to guarantee the convergence of parameter identification error. In addition, a valid data collection algorithm is given. It should be mentioned that a distinctive feature of the proposed filtering‐based concurrent learning adaptive control scheme is that the convergence rate of attitude tracking errors can be improved from asymptotical to exponential. Finally, simulation results are provided to illustrate the effectiveness of the proposed control schemes.