bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between urinary potassium excretion, serum potassium levels and cardiac injury in non-dialysis chronic kidney disease: KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)
Authors: Min Hyang Ki , Sung Su Ah , Jung Ji Yong , Oh Yun Kyu , Lee Kyu Beck , Park Sue K. , Oh Kook-Hwan , Ahn Curie , Lee Sung Woo 
Published: September 2023

AbstractAlthough the cardiovascular benefits of an increased urinary potassium excretion have been suggested, little is known about the potential cardiac association of urinary potassium excretion in patients with chronic kidney disease. In addition, whether the cardiac association of urinary potassium excretion was mediated by serum potassium levels has not been studied yet. We reviewed the data of 1633 patients from a large-scale multicentre prospective Korean study (2011–2016). Spot urinary potassium to creatinine ratio was used as a surrogate for urinary potassium excretion. Cardiac injury was defined as a high-sensitivity troponin T ≥ 14 ng/l. OR and 95 % (CI for cardiac injury were calculated using logistic regression analyses. Of 1633 patients, the mean spot urinary potassium to creatinine ratio was 49·5 (sd 22·6) mmol/g Cr and the overall prevalence of cardiac injury was 33·9 %. Although serum potassium levels were not associated with cardiac injury, per 10 mmol/g Cr increase in the spot urinary potassium to creatinine ratio was associated with decreased odds of cardiac injury: OR 0·917 (95 % CI 0·841, 0·998), P = 0·047) in multivariate logistic regression analysis. In mediation analysis, approximately 6·4 % of the relationship between spot urinary potassium to creatinine ratio and cardiac injury was mediated by serum potassium levels, which was not statistically significant (P = 0·368). Higher urinary potassium excretion was associated with lower odds of cardiac injury, which was not mediated by serum potassium levels.
Conditional Freedoms: Non-State Labour in Cuba between Institutional Delegitimisation and Civic Recognition
Authors: Thiemann Louis , González Marrero Claudia 
Published: September 2023

AbstractDuring the height of its power over everyday life, between 1968 and 1993, the Cuban Communist Party outlawed virtually all non-state labour and exchange. Since then, however, its continuity in power has increasingly depended on devolution: shifting responsibility for the provision of basic goods and services from failing state enterprises back to the self-employed. The latter now produce the majority of food and basic products; receive most of the national income from tourism, remittances and foreign investment; and generate most new jobs. Nevertheless, they subsist under a subaltern regime of fragile and conditional freedoms. The article adapts James Scott's consideration for the subaltern's ‘hidden transcripts’ and agencies to contemporary Cuba. It analyses the unavoidability of informal and illegal practices for daily subsistence; their naturalisation in society in contrast with their delegitimisation as opportunistic self-enrichment in party-controlled media; and how the self-employed resist such judgements in favour of more conciliatory civic visions.
Mechanistic understanding of individual outcomes: Challenges and alternatives to genetic designs
Authors: Bondarenko Olesya 
Published: September 2023

Abstract
I argue that advancing “second-generation” or mechanistic causal knowledge of individual outcomes requires a comprehensive research programme that uses a variety of different methods in addition to the ones described in the paper under discussion. I also highlight that environment-focused approaches can be as instrumental in identifying potential phenotypic causes as gene-focused approaches.
Behavior genetics and randomized controlled trials: A misleading analogy
Authors: Kaplan Jonathan Michael , Bird Kevin Andrew 
Published: September 2023

Abstract
Madole & Harden argue that just as the results of randomized controlled trials (RCTs) represent gains in causal knowledge and are useful, despite their limitations, so too are the findings of human behavior genetics. We argue that this analogy is misleading. Unlike RCTs, the results of human behavior genetics research cannot suggest efficacious interventions, nor point toward future research.
All that glisters is not gold: Genetics and social science
Authors: Burt Callie H. 
Published: September 2023

AbstractIn their target article, Madole & Harden offer an account of “what it means for genes to be causes” of social outcomes to bolster their claim that genetics should be incorporated into social science with practical implications. Here I object to several key features of their arguments, their representation of the state of science, and claims about the utility of genetics for social science and society.
Addressing genetic essentialism: Sharpening context in behavior genetics
Authors: Byrne Brian , Olson Richard K. 
Published: September 2023

Abstract
Evidence of a causal role for genes in human behavior underpins genetic essentialism, the scientifically flawed and socially hazardous idea that heritable characteristics are immutable. Behavior geneticists can challenge this idea by designing research that brings the contextual dependence of heritability estimates into sharper focus, and by incorporating a relevant statement into research reports and public outreach.
Drowning in shallow causality
Authors: Shen Hao , Feldman Marcus W. 
Published: September 2023

Abstract
It has been known for decades that inference concerning genetic causes of human behavioral phenotypes cannot be legitimately made from correlations among relatives. We claim that these inferential difficulties cannot be overcome by assigning different names to causes inferred from within-family and population-level genome-wide association studies (GWASs). For educational attainment, for example, unraveling gene–environment interactions requires more than new names for causes.
The social stratification of population as a mechanism of downward causation
Authors: Merchant Emily Klancher 
Published: September 2023

Abstract
This commentary expands on Burt's concept of downward causation to include any association between genomic variants and a given outcome that is forged through social practices rather than biochemical pathways. It proposes the social stratification of population, through which endogamy over a period of generations produces allele frequency differences between socioeconomic strata, as a mechanism of downward causation.
Genomics might not be the solution, but epistemic validity remains a challenge in the social sciences
Authors: Moreau David , Wiebels Kristina 
Published: September 2023

Abstract
We sympathize with many of the points Burt makes in challenging the value of genetics to advance our understanding of social science. Here, we discuss how recent reflections on epistemic validity in the behavioral sciences can further contribute to a reappraisal of the role of sociogenomics to explain and predict human traits, aptitudes, and achievement.
Social scientists would do well to steer clear of polygenic scores
Authors: Curtis David 
Published: September 2023

Abstract
The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.
Often wrong, sometimes useful: Including polygenic scores in social science research
Authors: Fletcher Jason 
Published: September 2023

Abstract
This commentary seeks to briefly outline a clear-eyed middle ground between Burt's claims that the inclusion of polygenic scores (PGSs) is essentially useless for social science and proponents' vast overstatements and over-interpretations of these scores. Current practice of including PGSs in social science is often wrong but sometimes useful.
Polygenic scores ignore development and epigenetics, dramatically reducing their value
Authors: Moore David S. 
Published: September 2023

AbstractPolygenic scores cannot elucidate the mechanisms that produce behavioral phenotypes (including “intelligence”). Therefore, they are unlikely to yield helpful interventions. Moreover, they are poor predictors of individuals' developmental outcomes. Burt's critique is well-supported by the details of molecular biology. Specifically, experiences affect epigenetic factors that influence phenotypes via how the genome functions, a fact that lends support to Burt's conclusions.
Polygenic scores for social science: Clarification, consensus, and controversy
Authors: Burt Callie H. 
Published: September 2023

Abstract
In this response, I focus on clarifying my arguments, highlighting consensus, and addressing competing views about the utility of polygenic scores (PGSs) for social science. I also discuss an assortment of expansions to my arguments and suggest alternative approaches. I conclude by reiterating the need for caution and appropriate scientific skepticism.
Political Experimentation in the Age of Global Revolutions
Authors: González Quintero Nicolás Alejandro 
Published: September 2023

AbstractThis essay reviews six recent books that explore how revolutionary upheavals pushed imperial and republican projects alike to experiment with novel political ideas and mechanisms. These initiatives came in response to calls for representation and equality throughout the Age of Revolution. In doing so, these books reveal the failures and successes of these projects in responding to these demands. The authors of these works show that republican and imperial processes of state-building and legitimacy-building did not have a predetermined outcome—quite the opposite. To constitute themselves as valid political alternatives, revolutionary, imperial, and republican projects had to adapt to different actors’ expectations, contingencies, and growing geopolitical tensions. By exposing those adaptation processes, the six books under review demonstrate that the Age of Revolution was a period of intense political experimentation across the ideological spectrum.
Urbs Giudi: text, translation and topography
Authors: Aitchison Nick 
Published: September 2023

ABSTRACTThis paper re-examines Bede’s reference to urbs Giudi for previously overlooked clues that may help to identify the location of this elusive fortress, somewhere in, on or near the Firth of Forth in what is now eastern central Scotland. After considering Bede’s abilities as a geographer, it assesses and challenges the persistent suggestion that urbs Giudi was on an island. It then analyses the implications of Bede’s use of Latin in medio sui and sinus by comparing these terms with other examples in Bede’s writings and elsewhere. This points to the importance of secondary and elliptical, rather than literal, senses of in medio sui and sinus respectively. The outcome of this is that urbs Giudi was located neither ‘in the middle of’ the Firth of Forth, nor ‘halfway along’ it, but further inland, on the Links of Forth, the meandering section of the Forth Estuary. This excludes all previously proposed locations for urbs Giudi with the exception of one, Stirling.
Closing the loop between horizon scanning and health technology assessment – an overview of topics submitted for appraisal in England
Authors: Khan Sarah Khalid , Gonzalez-Moral Sonia G. , Lanyi Kate , Ogunbayo Dapo , Craig Dawn 
Published: September 2023

Abstract

Objectives
Horizon scanning for health technology appraisal (HTA) in England involves topic notification to the National Institute for Health and Care Excellence (NICE) via technology briefings. This activity is undertaken by the Innovation Observatory with submission timelines designed to ensure that HTA decisions align with regulatory approval time. In this paper, we aimed to track and assess the progression and current status of the topics notified for HTA and provide a descriptive analysis of these topics.

Methods
Technology briefings were mapped from submission to NICE technology appraisal/highly specialized technologies recommendations from April 2017 until October 2021. This was done using a combination of searches on Google and NICE website, searching a downloadable spreadsheet containing NICE topic selection decisions, and querying NICE Topic Selection team. Analysis was undertaken regarding type of indications and interventions of submitted topics and published guidance.

Results
Six-hundred and ninety-three topics entered the NICE scoping process, of which 94 percent were prioritized. As of November 2021, approximately 39 percent of prioritized topics were in scoping/in progress, 31 percent were proposed/completed, 20 percent were suspended/terminated, and 4 percent were referred back to Innovation Observatory (IO) for further monitoring.

Conclusions
Our work demonstrates that horizon scanning for HTA is a complex and time-intensive process. Timelines and progress through HTA is challenging due to the growing number of innovative medicines, significant uncertainties, and limited transparency in clinical development and regulatory pathways. A better understanding of clinical trials and regulatory requirements may help eliminate some of this uncertainty and improve timely HTA.
Crossing the doorsteps for social reform: The social crusades of Florence Kelley and Ellen Richards
Authors: Soudan Gabrielle , Philippy David , Maas Harro 
Published: September 2023

ArgumentThis paper contrasts the research strategies of two women reformers, Florence Kelley and Ellen Swallow Richards, which entailed different strategies of social reform. In the early 1890s, social activist Florence Kelley used the social survey as a weapon for legal reform of the working conditions of women and children in Chicago’s sweatshop system. Kelley’s case shows that her surveys were most effective as “grounded” knowledge, rooted in a local community with which she was well acquainted. Her social survey, re-enacted by lawmakers and the press, provided the evidence that moved her target audience to legal action. Chemist and propagator of the Home Economics Movement Ellen Richards situated the social problem, and hence its solution, not in exploitative working conditions, but in the inefficient and wasteful usage of available resources by the poor. Laboratory work, she argued, would enable the development of optimal standards, and educational programs should bring these standards to the household by means of models and exhibits. With this aim, she constructed public spaces that she ran as food laboratories and sanitary experiments. Kelley and Richards thus crossed the doorsteps of the household in very different ways. While Florence Kelley entered the household to change the living and working conditions of the poor by changing the law, Richards flipped the household inside out by bringing women into hybrid public laboratory spaces to change their behavior by experiment and instruction.
The correlation between humoral immune responses and severity of clinical symptoms in COVID-19 patients
Authors: Akbarian Shadi , Sheikhi Mehdi , Khedri Parichehr , Baharifar Narges , Khalaf Shamsabadi Fatemeh , Davidi Mohammad Reza , Khazaei Hossein Ali , Assarian Hamidali , Sheikhi Abdolkarim 
Published: September 2023

Abstract
The SARS-CoV-2 pandemic persists with global repercussions. Initial COVID-19 symptoms encompass pneumonia, fever, myalgia, and fatigue. The human immune system produces IgM and IgG antibodies in response to SARS-CoV-2. Despite previous research, a comprehensive understanding of the interplay between clinical manifestations and humoral immune responses remains elusive. This study aims to scrutinize this association. 134 COVID-19 patients were enrolled, and stratified into mild, moderate, and severe symptom groups. Serum IgM and IgG levels were assessed thrice at one-month intervals using ELISA. The findings reveal significant elevation in serum IgG levels in moderate compared to mild cases (P < 0.001). Additionally, IgG production was significantly heightened in severe cases compared to both mild (P < 0.0001) and moderate (P < 0.05) groups. IgM and IgG levels peaked initially and diminished over time. While anti-SARS-CoV-2 antibodies are expected to confer protection, the direct correlation between IgG levels and symptom severity may arise from delayed immune activation, resulting in an intense antibody response in severe cases. Given evidence linking delayed immune function with a dysregulated innate immune response, comprehensive data collection should encompass not only serum IgG and IgM, but also early measurement of type I interferons at symptom onset. This could provide a more thorough understanding of COVID-19 progression.
Relativizing the A Priori By Way of Reflective Judgement
Authors: Vaccarino Bremner Sabina 
Published: September 2023

AbstractAn influential strand in philosophy of science claims that scientific paradigms can be understood as relativized a priori frameworks. Here, Kant’s constitutive a priori principles are no longer held to establish conditions of possibility for knowledge which are unchanging and universally true, but are restricted only to a given scientific domain. Yet it is unclear how exactly a relativized a priori can be construed as both stable and dynamical, establishing foundations for current scientific claims while simultaneously making intelligible the transition to a subsequent framework. In this article, I show that important resources for this problem have been overlooked in Kant’s theory of reflective judgement in the third Critique. I argue that Kant accorded the task of formulating new scientific laws to reflective judgement, which is charged with forming new ‘universals’ that guide the experience of nature. I show that this is the very task attributed to the relativized a priori: the constitution of a given conceptual framework, not of the conditions for object-reference as such. I conclude that Kant’s considered conception of science encompasses the operations of both reflective and determining judgement. Relativizations of the a priori should follow Kant’s lead.
Genetic fingerprinting ofZiziphus jujubaby using SCoT and REMAP molecular markers
Authors: Mohajer Kaboli Zohreh , Sheidai Masoud , Koohdar Fahimeh 
Published: September 2023

AbstractJujube is both consumed as a food source and medicinal plant in local markets. It is expected that different geographical populations ofZiziphus jujuba, differ in their genetic content as they grow in different ecological conditions. It is important to have detailed information on population genetic structure and the available genetic variability to make a proper germplasm collection of jujube. We have no data on jujube populations of Iran based on SCoT and REMAP molecular markers, and therefore we planned a population genetic study of these trees in 10 geographical areas. We used SCoT and REMAP molecular markers for our genetic investigation. We found the loci with a high value of Gst (1.00) in SCoT and REMAP markers that can be used in fingerprinting of jujube.
Effect of Inverse Compton Cooling on Relativistic Particles Accelerated at Shear Boundary Layers in Relativistic Jets
Authors: Chand Tej , Böttcher Markus 
Published: September 2023

AbstractRecent theoretical considerations and observational evidence evince the spine-sheath morphology of relativistic jets emitted from active galactic nuclei (AGNs) or gamma-ray bursts (GRBs). The resulting shear boundary layers (SBLs) are likely to be an avenue for particle acceleration in relativistic jets. The effect of radiation drag on radiating particles has yet to be addressed in most studies of particle acceleration at shear boundary layers, even though radiative cooling may considerably affect particle dynamics. By using particle-in-cell simulations, we study the effects of inverse Compton cooling on particle dynamics and emerging particle spectra.
A WISE perspective of the blazar hunt in the γ-ray sky
Authors: Massaro Francesco , D’Abrusco Raffaele 
Published: September 2023

AbstractThanks to the data of the WISE all-sky survey we discovered that the non-thermal infrared emission of blazars, the largest population of associated γ-ray sources, has peculiar spectral properties. Here we provide a summary of all results achieved on the infrared–γ-ray connection. We also show results on the latest statistical analysis of the tight correlation between the mid-infrared colors and the γ-ray spectral index for Fermi blazars, a connection that links both emitted powers and spectral shapes of particles accelerated in blazar jets over ten decades in frequency of the electromagnetic spectrum. Finally, we outline all developments performed in the last decade achieved using the infrared– γ-ray connection to discover hundreds of new blazars within the sample of unidentified γ-ray sources thanks to optical spectroscopic observations.
Radio Polarization: A Powerful Resource for Understanding the Blazar Divide
Authors: Baghel Janhavi , Kharb P. , Silpa S. , Ho Luis C. , Harrison C. M. 
Published: September 2023

AbstractWith high-sensitivity kiloparsec-scale radio polarimetry, we can examine the jet-medium interactions and get a better understanding of the blazar divide in radio-loud (RL) AGN. We are analyzing the radio polarimetric observations with the EVLA and GMRT of 24 quasars and BL Lacs belonging to the Palomar-Green (PG) sample. The RL quasars show extensive polarisation structures in their cores, jets, lobes, and hotspots, whereas preliminary results suggest that BL Lacs exhibit polarisation primarily in their cores and inner jet regions. These findings imply that both intrinsic (central engine-related) and extrinsic (environment-related) variables are important in the formation of the blazar subclasses. The Fanaroff-Riley (FR) dichotomy can also be studied assuming RL unification and looking through the lens of blazars. Due to the radio-unbiased nature of the optically/UV-selected PG sample, we find a large fraction of the PG quasars are restarted, distorted (S- or X-shaped), or have a hybrid FR morphology.
Multiwavelength monitoring of the nucleus in PBC J2333.9–2343: A giant radio galaxy with a Blazar-like core
Authors: Hernández-García L. , Panessa F. , Bruni G. , Bassani L. , Arévalo P. , Patiño-Alvarez V. M. , Tramacere A. , Lira P. , Sánchez-Sáez P. , Bauer F. E. , Chavushyan V. , Carraro R. , Förster F. , Muñoz Arancibia A. M. , Ubertini P. 
Published: September 2023

AbstractWe present an observational multiwavelength campaign during 2018–19 for PBC J2333.9–2343, a giant radio galaxy with a bright central core associated to a blazar nucleus, whose structure could be due to a significant jet reorientation. We report flux increases by a factor of two or more on timescales shorter than a month, resembling flaring events. The cross correlation between the NIR and optical bands shows quasi-simultaneous variations arising from the jet. The optical variability properties of PBC J2333.9–2343 are more comparable to a sample of blazars than to non-blazar AGN. The SED of the nucleus shows two peaks, with a derived jet angle of 3 degrees, also typical of a blazar. Therefore, we confirm the presence of a blazar-like core in the center of this galaxy.