bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bilayer High-Temperature Dielectric Film with Superior Breakdown Strength and Energy Storage Density
Authors: Ping Jiang-Bo , Feng Qi-Kun , Zhang Yong-Xin , Wang Xin-Jie , Huang Lei , Zhong Shao-Long , Dang Zhi-Min 
Published: June 2023

AbstractThe further electrification of various fields in production and daily life makes it a topic worthy of exploration to improve the performance of capacitors for a long time, including thin-film capacitors. The discharge energy density of thin-film capacitors that serves as one of the important types directly depends on electric field strength and the dielectric constant of the insulation material. However, it has long been a great challenge to improve the breakdown strength and dielectric constant simultaneously. Considering that boron nitride nanosheets (BNNS) possess superior insulation and thermal conductivity owing to wide band gap and 2-dimensional structure, a bilayer polymer film is prepared via coating BNNS by solution casting on surface of polyethylene terephthalate (PET) films. By revealing the bandgap and insulating behavior with UV absorption spectrum, leakage current, and finite element calculation, it is manifested that nanocoating contributes to enhance the bandgap of polymer films, thereby suppressing the charge injection by redirecting their transport from electrodes. Worthy to note that an ultrahigh breakdown field strength (~ 736 MV m−1), an excellent discharge energy density (~ 8.77 J cm−3) and a prominent charge–discharge efficiency (~ 96.51%) are achieved concurrently, which is ascribed to the contribution of BNNS ultrathin layer. In addition, the modified PET films also have superior comprehensive performance at high temperatures (~ 120 °C). The materials and methods here selected are easily accessible and facile, which are suitable for large-scale roll-to-roll process production, and are of certain significance to explore the methods about film modification suitable for commercial promotion.
Mixed-effects location-scale model based on generalized hyperbolic distribution
Authors: Fujinaga Yuki , Masuda Hiroki 
Published: June 2023

AbstractMotivated by better modeling ofintra-individualvariability in longitudinal data, we propose a class of location-scale mixed-effects models, in which the data of each individual is modeled by a parameter-varying generalized hyperbolic distribution. We first study the local maximum-likelihood asymptotics and reveal the instability in the numerical optimization of the log-likelihood. Then, we construct an asymptotically efficient estimator based on the Newton–Raphson method based on the original log-likelihood function with the initial estimator being naive least-squares-type. Numerical experiments are conducted to show that the proposed one-step estimator is not only theoretically efficient but also numerically much more stable and much less time-consuming compared with the maximum-likelihood estimator.
Functional and Sport-Specific Outcome Following Traumatic First-Time Shoulder Dislocation and Arthroscopic Surgical Repair in Rock Climbers
Authors: Simon Michael , Geffel Leonid , Lutter Christoph , Schöffl Volker 
Published: June 2023

Introduction Traumatic shoulder dislocations rank among the most common shoulder injuries in climbers, with rising numbers over the last years. The objective of this study was to analyze the outcome following traumatic first-time shoulder dislocation and subsequent surgical treatment in this population. Methods In a retrospective study, climbers who experienced a traumatic shoulder dislocation were treated with an arthroscopic repair of the labrum-ligament complex (LLC). The functional outcome was assessed with a standardized questionnaire and clinical examination, including the Constant Murley and Single Assessment Numeric Evaluation scores. The sport-specific outcome was analyzed using the Union Internationale des Associations d’Alpinisme (UIAA) scale of difficulty and a sport-specific outcome score. Results The functional and sport-specific outcome for 27 climbers (20 men; 7 women; 3 with bilateral injuries; age, 34±11 [17–61] y; data presented as mean±SD [range]) was assessed 53±29 (12–103) mo after surgery. The postoperative Constant Murley score was 95±8 (67–100) points. At follow-up, 93% (n=25) of patients had started climbing again. Twenty-one climbers (78%) reached a climbing level within the range of ±0.33 UIAA grades of their initial capability or even exceeded their preinjury grade. Only 7% (n=2) of the patients had a recurrent shoulder dislocation, leading to a secondary surgery, and, therefore, required ongoing postoperative treatment at the time of follow-up. Conclusions Arthroscopic repair of the LLC following first-time traumatic shoulder dislocation in climbers shows a good outcome and a low recurrence rate. After surgery, most patients are able to regain a high level of rock-climbing ability.
Steep ice – progress and future challenges in research on ice cliffs
Authors: Steiner Jakob F. , Buri Pascal , Abermann Jakob , Prinz Rainer , Nicholson Lindsey 
Published: June 2023

AbstractIce cliffs are features along ice sheet margins, along tropical mountain glaciers, at termini of mountain glaciers and on debris-covered glacier tongues, that have received scattered attention in literature. They cover small relative areas of glacier or margin surface respectively, but have been involved in two apparent anomalies. On the one hand, they have been identified as potential hotspots of extreme melt rates on debris-covered tongues contributing to their relatively rapid ablation, compared to the surrounding glacier surface. On the other hand, they appear where the ice margin is stable (or temporarily advancing) even under conditions of negative mass balance. In this manuscript, we recapitulate why ice cliffs remain interesting features to investigate and what we know about them so far. We conclude by suggesting to further investigate their genesis and variable morphology and their potential as windows into past climates and processes.
An Assessment of the Climate Damage Costs of European Short-Lived Climate Forcers
Authors: Åström Stefan , Källmark Lovisa 
Published: June 2023

AbstractIn addition to effects from greenhouse gases, climate change is affected by short-lived climate forcers (SLCF). These are often co-emitted with carbon dioxide, and some are regulated air pollutants. In the governance of these pollutants, established estimates of damage costs of pollution inform benefit–cost analyses. However, climate change impact of SLCFs is omitted from these estimates. The purpose of this study is to calculate economic damage costs of air pollutants’ effect on climate change and compare these with established damage costs. Focus is on European emissions governed in the EU National Emission Reduction Commitments Directive during 2020–2050. We use well-known SLCF emission metrics and multiply with literature values on social costs of methane to calculate climate damage costs of SLCFs. The results indicate that average absolute climate damage costs are highest for black carbon ($59,500/ton in 2050) and lowest for nonmethane volatile organic compounds ($661/ton). Our indicative values are likely underestimations. Indicative climate damage costs are usually lower than established damage costs, with notable exceptions. We propose that more detailed studies are necessary, and that inclusion of climate damage costs into economic valuation of SLCFs is important for future air pollution and climate benefit–cost analyses.
PREVENTING THE INFINITE REGRESS: DISCRETION, BARS TO RELIEF AND THE STRUCTURE OF EQUITY
Authors: Tiverios Nicholas A. 
Published: June 2023

AbstractA growing body of literature has emphasised the role of equity as a body of second order principles. These scholars argue that what makes equity distinct is that it assumes a particular outcome at common law, but then controls or disables one party's insistence on her legal entitlements. Where do equitable bars to relief fit within such accounts? This article argues that equitable bars to relief fit comfortably with the view that equity is second order law. This is for a simple reason: equity prevents the unjust exercise of legal entitlements. However, equitable rules are also amenable to being exercised unjustly. To prevent equitable rules being abused, equitable doctrines require some limited discretion to be built in. If this were not the case, then the general law would require a third set of rules to control equity and then a fourth set of rules to control those rules (ad infinitum).
When low level of constraint and effectiveness go hand in hand: The example of the 2005 Convention
Authors: Guèvremont Véronique , Varin Clémence 
Published: June 2023

AbstractThe year 2022 marks 15 years since the entry into force of the United Nations Educational, Scientific and Cultural Organization’s 2005 Convention on the Protection and Promotion of the Diversity of Cultural Expressions. Among its objectives, this treaty aims at acknowledging the specific nature – economic and cultural – of cultural activities, goods, and services, reaffirming the sovereign right of states to adopt or implement measures they deem appropriate for the protection and the promotion of the diversity of cultural expressions as well as reinforcing international cooperation for more balanced cultural exchanges. Since its adoption, this treaty has been criticized for its low level of constraint. However, data collected over the years show that parties rely extensively on the Convention to undertake diverse initiatives to achieve the treaty’s objectives. Based on concrete examples, this article aims to show that the effectivity of a legal instrument does not only rely on its degree of constraint but also on other factors, including monitoring mechanisms put in place in the context of its implementation.
Reach and uptake of mass drug administration for worm infections through health facility-, school-, and community-based approaches in two districts of Zambia: a call for scale-up
Authors: Halwiindi Hikabasa , Chooka Lubombo , Phiri Masauso Moses , Tapisha Buumba , Masenga Sepiso K. , Mudenda Jolezya , Chimfwembe Kingford , Mugode Mwitwa , Hamooya Benson M. 
Published: June 2023

Abstract
Helminthiases cause significant health deficiencies among children. Mass administration of anthelminthic drugs has had significant results to counter these effects. We assessed the effects on and determinants of treatment coverage of community-directed treatment among children in Zambia, using cross-sectional survey data, and using chi-square test and multilevel mixed-effects model. Of 1,416 children, 51.5% were males and 48.5% were females, while 52.7%, were school-age, and 47.3% were preschool-age. Overall treatment coverage was 53.7% (95% confidence interval (CI) 51.1, 56.4). More preschool-age children were treated compared to school-age ones, 65.2% versus 43.4%, P < 0.001. Similarly, more children under community-directed intervention were treated compared to regular mass drug administration (65.2% versus 51.1 %, P < 0.001). Treatment among school-age participants was associated with being male (Adjusted Odds Ratio (AOR 1.83, 95%CI 1.23–2.72), receiving community-directed treatment (AOR 5.53; 95%CI 3.41–8.97), and shorter distance to health facility (AOR 2.20; 95%CI 1.36–3.56). Among preschool-aged participants, treatment was associated with being residents of Siavonga district (AOR 0.03; 95%CI 0.01–0.04) and shorter distance to health facility (AOR 0.35; 95%CI 0.21–0.59). Community-directed treatment can be used to increase treatment coverage, thereby contribute to 2030 vision of ending epidemics of neglected tropical diseases.
Comparison of foods and beverages served and consumed in Child and Adult Care Food Program-participating childcare centres to national guidelines
Authors: Mozaffarian Rebecca S , Carter Sonia , Bovenzi Mary C , Kenney Erica L 
Published: June 2023

AbstractObjective:The federal Child and Adult Care Food Program (CACFP) sets minimum nutrition and portion size standards for meals served in participating childcare programs. CACFP has been associated with more nutritious meals served. It is unclear, however, whether CACFP results in children’s dietary intake being aligned with national recommendations. We assess whether children’s dietary intake in CACFP-participating childcare centres meets benchmarks set by the Dietary Guidelines for Americans (DGA).Design:This is a cross-sectional study. We used direct observation to estimate quantities of foods/beverages served and consumed per child. Mean amounts served per child per day were compared with CACFP portion size requirements for each component (fruits, vegetables, milk and meat/meat alternate). Mean amounts of foods/beverages consumed were compared with DGA recommendations (energy content, fruits, vegetables, whole/refined grains, dairy, protein and added sugars). One sample t-tests evaluated if quantities served and consumed were different from CACFP and DGA standards, respectively.Setting:Six CACFP-participating childcare centres.Participants:2–5 year-old children attending childcare.Results:We observed forty-six children across 166 child meals. Most meals served met CACFP nutrition standards. Compared with CACFP portion size standards, children were served more grains at breakfast and lunch; more fruits/vegetables at lunch but less at breakfast and snack and less dairy at all eating occasions. Compared with DGA recommendations, children under-consumed every food/beverage category except grains during at least one eating occasion.Conclusions:Children were served quantities of foods/beverages mostly consistent with CACFP portion size requirements, but had sub-optimal intake relative to DGA. More research is needed to help children consume healthy diets in childcare.
Turbulent Energy Transfer at Dipolarization Fronts
Authors: Liu C. M. , Cao J. B. , Xing X. N. , Chen Z. Z. 
Published: June 2023

AbstractDipolarization fronts (DFs), ion‐scale magnetic transients characterized by dramatic enhancement of northward magnetic field, have been documented as crucial energy transfer regions in the magnetosphere. DF‐driven energy transfer has hitherto been studied mainly in the laminar regime. Energy transfer driven by turbulent processes, however, remains unclear. Here we perform a comprehensive investigation of turbulent energy transfer (TET) developed at DFs, via using high‐cadence data from Magnetospheric Multiscale mission. We find that: (a) TET is equally governed by energy loads and generators, different from laminar energy transfer which is typically dominated by energy loads; (b) ion and electron currents play comparable roles in driving TET; (c) TET is positively correlated with local magnetic field strength and ion speed; (d) TET shows asymmetric global distributions along the dawn‐dusk direction. These features implicate that TET is primarily related to electromagnetic turbulence at electron‐ion hybrid scales. These new results, uncovering unique characteristics of DF‐driven TET, can deeply advance our understanding of energy budgets in the magnetosphere.
Integrated multi-omics analyses reveal homology-directed repair pathway as a unique dependency in near-haploid leukemia
Authors: Liu-Lupo Yunpeng , Ham James Dongjoo , Jeewajee Swarna K. A. , Nguyen Lan , Delorey Toni , Ramos Azucena , Weinstock David M. , Regev Aviv , Hemann Michael T. 
Published: June 2023

AbstractWhole chromosome losses resulting in near-haploid karyotypes are found in a rare subgroup of treatment-refractory acute lymphoblastic leukemia. To systematically dissect the unique physiology and uncover susceptibilities that can be exploited in near-haploid leukemia, we leveraged single-cell RNA-Seq and computational inference of cell cycle stages to pinpoint key differences between near-haploid and diploid leukemia cells. Combining cell cycle stage-specific differential expression with gene essentiality scores from a genome-wide CRISPR-Cas9-mediated knockout screen, we identified the homologous recombination pathway component RAD51B as an essential gene in near-haploid leukemia. DNA damage analyses revealed significantly increased sensitivity of RAD51-mediated repair to RAD51B loss in the G2/M stage of near-haploid cells, suggesting a unique role of RAD51B in the homologous recombination pathway. Elevated G2/M and G1/S checkpoint signaling was part of a RAD51B signature expression program in response to chemotherapy in a xenograft model of human near-haploid B-ALL, and RAD51B and its associated programs were overexpressed in a large panel of near-haploid B-ALL patients. These data highlight a unique genetic dependency on DNA repair machinery in near-haploid leukemia and demarcate RAD51B as a promising candidate for targeted therapy in this treatment-resistant disease.
A historical review of 'phossy jaw'
Authors: Devlin Hugh 
Published: June 2023

AbstractThe aim of this article is to stimulate interest and discussion on the pathogenesis of 'phossy jaw'. Historical evidence from newspapers and articles of the time is presented, as other scientific evidence is largely absent. It has stimulated considerable interest in present-day media due to the struggles of nineteenth century reformers to improve working conditions against an apathetic government and weak enforcement of regulation. Those afflicted were often young women who suffered severe pain, loss of segments of jaw, and disfigurement.
Nuclear complement C3b promotes paclitaxel resistance by assembling the SIN3A/HDAC1/2 complex in non-small cell lung cancer
Authors: Wang Xiaochao , Hao Yan , Chen Jianfeng , Ding Peipei , Lv Xinyue , Zhou Danlei , Li Ling , Li Luying , Xu Yanqing , Zhu Yumeng , Zhang Wei , Chen Lu , Liao Tian , He Xianghuo , Ji Qing-Hai , Hu Weiguo 
Published: June 2023

AbstractIn addition to the classical role as a serum effector system of innate immunity, accumulating evidence suggests that intracellular complement components have indispensable functions in immune defense, T cell homeostasis, and tumor cell proliferation and metastasis. Here, we revealed that complement component 3 (C3) is remarkably upregulated in paclitaxel (PTX)-resistant non-small cell lung cancer (NSCLC) cells and that knockdown of C3 promoted PTX-induced cell apoptosis, sensitizing resistant cells to PTX therapy. Ectopic C3 decreased PTX-induced apoptosis and induced resistance to PTX treatment in original NSCLC cells. Interestingly, C3b, the activated fragment of C3, was found to translocate into the nucleus and physically associate with the HDAC1/2-containing SIN3A complex to repress the expression of GADD45A, which plays an important role in cell growth inhibition and apoptosis induction. Importantly, C3 downregulated GADD45A by enhancing the binding of the SIN3A complex with the promoter of GADD45A, thus decreasing the H3Ac level to compress chromatin around the GADD45A locus. Subsequently, ectopic GADD45A promoted PTX-induced cell apoptosis, sensitizing resistant cells to PTX therapy, and insufficiency of GADD45A in original cancer cells induced resistance to PTX treatment. These findings identify a previously unknown nucleus location and oncogenic property for C3 in chemotherapy and provide a potential therapeutic opportunity to overcome PTX resistance.
Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction
Authors: Fernandes Andreia R. , Martins João P. , Gomes Edgar R. , Mendes César S. , Teodoro Rita O. 
Published: June 2023

AbstractWired neurons form new presynaptic boutons in response to increased synaptic activity, however the mechanism(s) by which this occurs remains uncertain. Drosophila motor neurons (MNs) have clearly discernible boutons that display robust structural plasticity, being therefore an ideal system in which to study activity-dependent bouton genesis. Here, we show that in response to depolarization and in resting conditions, MNs form new boutons by membrane blebbing, a pressure-driven mechanism that occurs in 3-D cell migration, but to our knowledge not previously described to occur in neurons. Accordingly, F-actin is decreased in boutons during outgrowth, and non-muscle myosin-II is dynamically recruited to newly formed boutons. Furthermore, muscle contraction plays a mechanical role, which we hypothesize promotes bouton addition by increasing MN confinement. Overall, we identified a mechanism by which established circuits form new boutons allowing their structural expansion and plasticity, using trans-synaptic physical forces as the main driving force.
A crucial role for dynamic expression of components encoding the negative arm of the circadian clock
Authors: Wang Bin , Zhou Xiaoying , Kettenbach Arminja N. , Mitchell Hugh D. , Markillie Lye Meng , Loros Jennifer J. , Dunlap Jay C. 
Published: June 2023

AbstractIn the Neurospora circadian system, the White Collar Complex (WCC) drives expression of the principal circadian negative arm component frequency (frq). FRQ interacts with FRH (FRQ-interacting RNA helicase) and CKI, forming a stable complex that represses its own expression by inhibiting WCC. In this study, a genetic screen identified a gene, designated as brd-8, that encodes a conserved auxiliary subunit of the NuA4 histone acetylation complex. Loss of brd-8 reduces H4 acetylation and RNA polymerase (Pol) II occupancy at frq and other known circadian genes, and leads to a long circadian period, delayed phase, and defective overt circadian output at some temperatures. In addition to strongly associating with the NuA4 histone acetyltransferase complex, BRD-8 is also found complexed with the transcription elongation regulator BYE-1. Expression of brd-8, bye-1, histone h2a.z, and several NuA4 subunits is controlled by the circadian clock, indicating that the molecular clock both regulates the basic chromatin status and is regulated by changes in chromatin. Taken together, our data identify auxiliary elements of the fungal NuA4 complex having homology to mammalian components, which along with conventional NuA4 subunits, are required for timely and dynamic frq expression and thereby a normal and persistent circadian rhythm.
Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing
Authors: Wallis Tristan P. , Jiang Anmin , Young Kyle , Hou Huiyi , Kudo Kye , McCann Alex J. , Durisic Nela , Joensuu Merja , Oelz Dietmar , Nguyen Hien , Gormal Rachel S. , Meunier Frédéric A. 
Published: June 2023

AbstractSingle-molecule localization microscopy techniques are emerging as vital tools to unravel the nanoscale world of living cells by understanding the spatiotemporal organization of protein clusters at the nanometer scale. Current analyses define spatial nanoclusters based on detections but neglect important temporal information such as cluster lifetime and recurrence in “hotspots” on the plasma membrane. Spatial indexing is widely used in video games to detect interactions between moving geometric objects. Here, we use the R-tree spatial indexing algorithm to determine the overlap of the bounding boxes of individual molecular trajectories to establish membership in nanoclusters. Extending the spatial indexing into the time dimension allows the resolution of spatial nanoclusters into multiple spatiotemporal clusters. Using spatiotemporal indexing, we found that syntaxin1a and Munc18-1 molecules transiently cluster in hotspots, offering insights into the dynamics of neuroexocytosis. Nanoscale spatiotemporal indexing clustering (NASTIC) has been implemented as a free and open-source Python graphic user interface.