bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and Risk of Infections in Patients With Radiographic Axial Spondyloarthritis Receiving Biologic Therapies: A Prospective Observational Study Using the KOBIO Registry
Authors: Ko Kyung Min , Moon Su-Jin 
Published: January 2025

ObjectiveThis study aimed to assess the occurrence of infection and risk factors among patients with radiographic axial spondyloarthritis (r-axSpA) treated with biologics in a real-world setting.MethodsThis prospective observational cohort study included patients with r-axSpA from the Korean College of Rheumatology Biologics (KOBIO) registry who initiated or switched to a biologic agent between December 2012 and December 2023. The primary outcome was the first occurrence of any infection, ranging from mild to severe, classified by organ system. The infection rates per 1000 person-years (PY), with 95% CI, were calculated using the Poisson distribution method. Cox proportional hazard regression models—adjusted for confounders—estimated hazard ratios for infection risk, considering only the first infection event.ResultsThis analysis included 2129 patients with a total of 7107.67 PY of follow-up. The predominant infections observed were of the upper and lower respiratory tract (25.89/1000 PY), followed by herpes zoster (HZ; 6.13/1000 PY). Multivariate Cox regression analysis revealed significant risk factors for infection, including advanced age, ischemic heart disease (IHD), diabetes mellitus (DM) with complications, chronic kidney disease (CKD), and peripheral arthritis. In contrast, male sex was identified as a protective factor against the development of infections.ConclusionThe infection rate was 39.39 events/1000 PY, with respiratory tract infections being most common, followed by HZ. Significant risk factors for the occurrence of infection in patients with r-axSpA treated with biologics included advanced age, female sex, IHD, DM with complications, CKD, and peripheral arthritis. These findings emphasize infection risk assessment, particularly in high-risk patients, to optimize the safety of biologic therapy in r-axSpA.
Epidemiology of Antisynthetase Syndrome and Risk of Malignancy in a Population-Based Cohort (1998-2019)
Authors: Coffey Caitrin M. , Hulshizer Cassondra A. , Crowson Cynthia S. , Ryu Jay H. , Ernste Floranne C. 
Published: January 2025

ObjectivePopulation-based epidemiology studies about antisynthetase syndrome (ASS) are lacking. Our aims were to determine the incidence and prevalence of ASS and assess malignancy risk among patients following ASS diagnosis.MethodsA retrospective, population-based cohort of adults with incident ASS residing in Olmsted County, Minnesota, in 1998-2019, was assembled. Fulfillment of Solomon classification criteria for ASS and clinical data were collected by manual chart review. Patients were followed until death, migration from the area, or December 31, 2019. Malignancy was defined by physician diagnosis in the medical record. Incidence rate was age- and sex-adjusted to the 2010 US White population. Point prevalence rate was obtained on January 1, 2015.ResultsThirteen patients with ASS were identified (7 [54%] female, 13 [100%] White, median age 44.9 [IQR 41.9-58.3] years). The age- and sex-adjusted incidence of ASS was 0.56 (95% CI 0.25-0.87) per 100,000 population. Incidence was highest in the 50-59 age group. Age- and sex-adjusted prevalence was 9.21 per 100,000 (95% CI 3.44-14.98). Two of 13 (15%) were diagnosed with malignancy within the follow-up interval and none within 3 years of ASS diagnosis. At median 11.9 (IQR 7.0-13.4) years of follow-up, 12/13 (92%) of patients were alive.ConclusionASS is rare, with an incidence of 0.56 per 100,000 population and prevalence of 9.21 per 100,000. In this cohort, incidence was similar between male and female individuals, and was highest in persons aged 50-59 years. None of the patients developed malignancy within 3 years of ASS diagnosis.
Contribution to the study of the theoretical foundations of archaeozoological research on recent European and Near Eastern prehistory (Abridged version)
Authors: Jeunesse Christian 
Published: January 2025

Our dependence on common sense when it comes to transforming the truncated documentation from our excavation campaigns into interpretative narrative has been regularly emphasised since André Leroi-Gourhan. Its counterpart, and one of the conditions of its existence, is our lack of ethnological culture. We know too little about the characteristics, properties and modes of operation of the vast category of pre-state societies, of which prehistoric European societies are, after all, a part. The aim of ethnoarchaeology and ethnographic comparatism is precisely to familiarise us with this universe, so strange in some respects to our Western eyes, of societies that were once called “primitive”. The article begins with an epistemological reflection on the way in which a set of presuppositions conditions the interpretations of researches devoted to the exploration of the human-animal relationship in societies of late European prehistory. We attempt to show how an implicit model inspired in particular by our knowledge of historical peasantry and a biased conception of the functioning of the primitive economy (both being part of our “intellectual habitus” a scholarly conditioned form of common sense) slips into the process of knowledge production, between the examination of raw facts and the elaboration of interpretations. A detailed examination of pig farming in the New Guinea Highlands then serves to show that the presuppositions of this model are anything but universal. It also leads us to develop alternative models likely to shed new light on prehistoric animal husbandry, for example on the conditions of emergence of the first domestications in the Near East and elsewhere. In this way, we hope to contribute to the development of a catalogue of the forms of animal husbandry known in pre-state, pre-literary and animist societies, both current and sub-actual, with the aim of making it a tool for understanding prehistoric animal husbandry. The underlying idea, which is one of the “commandments” of ethnoarchaeology, is that the depth of the political, social and ontological rupture introduced by the emergence of the state and universal religions is such that the level of proximity between present-day pre-state and prehistoric societies will necessarily be greater than that between the latter and the historical European societies that are the main source of inspiration for the implicit model mentioned above.
Abdominal obesity as a predictor for response to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema
Authors: Wasfy Tamer E. , Soliman Shaimaa S. , Hawash Nehad , Gad Elham A. 
Published: January 2025

Background and aim
Diabetic macular edema (DME) is a major cause of visual disturbance among diabetic patients. Anti-vascular endothelial growth factor (anti-VEGF) therapy has been widely used to treat DME. Obesity is associated with higher levels of circulating VEGF, which may worsen diabetic retinopathy and hinder the response to anti-VEGF therapy. This study aimed to assess the effect of abdominal obesity on response to anti-VEGF in patients with DME.

Patients and methods
The prospective study included 301 eyes of 199 diabetic patients with centrally involved DME. The central macular thickness before and after three consecutive intravitreal injections of anti-VEGF were measured by optical coherence tomography. The patient was considered as having a “poor response” if the central macular thickness has reduced by less than 20% of the pre-injection thickness. The BMI, waist–hip ratio (WHR), and other risk factors were tested for their association with “poor response.”

Results
The mean age of the included patients was 56.34±9.97 years, and 103 (51.8%) were females. The mean±SD WHR among males was 0.94±0.12, and among females was 0.86±0.07, ranging from 0.68 to 1.16. “Poor response” to therapy was noted in 68 (34.2%) patients. Univariate regression showed that BMI, WHR, fasting blood sugar, and glycosylated hemoglobin were significantly associated with “poor response,” while multivariate regression analysis showed that only glycosylated hemoglobin was significantly associated with “poor response.”

Conclusion
Abdominal obesity can significantly contribute to “poor response” to anti-VEGF therapy among diabetic patients with DME.
A Narrative Approach to Exploring Life Changes Among Middle-Aged Women: A Qualitative Study
Authors: Rezaee Nasrin , Ghaljeh Mahnaz 
Published: January 2025

Background:
Middle age serves as a crucial transitional phase between youth and old age in women’s health, making it a critical period for women. Accordingly, this study aimed to explore the experiences of life changes among middle-aged women.

Materials and Methods:
This study was conducted using qualitative content analysis from September to December 2022 in Zahedan. The participants included 10 middle-aged women selected via purposive sampling. Data were collected through individual face-to-face interviews, and all interviews were subsequently transcribed and analyzed. Categories representing the beginning, middle, and end of the narratives were extracted. First, thematic similarities were identified, leading to the emergence of subcategories. Then, the related subcategories were reviewed and placed into the same category.

Results:
At the beginning of the narratives, the identified subcategories included perception of middle age, gaining experience, and behavior change. In the middle of the narratives, understanding the developmental stages and gaining experience in managing life were extracted as the subcategories. At the end of the narratives, maturity was identified as the main category.

Conclusions:
The findings from this study revealed that development occurs through the accumulation of experience. Although this study did not explore development in contextual terms, addressing and identifying the challenges of middle age in their context may facilitate quicker development. Furthermore, recognizing and investigating physical problems associated with middle age could lead to more timely treatment.
The Validation of Diabetes Mellitus Discharge Planning Module Incorporated into the Summary of Diabetes Self-Care Activity
Authors: Said Asbath , Said Faridah Mohd , Nambiar Nisha 
Published: January 2025

Background:
In Indonesia, several hospitals have designed various forms of discharge planning in line with the guidelines provided by the Indonesian Endocrinology Association. These initiatives were implemented to enhance the quality of healthcare service. Despite the efforts made by the government, the rate of non-compliance (9%) and readmission (20%) has continued to increase. This indicates that there is a need to reevaluate the existing discharge planning module. Therefore, this study aims to validate the contents of the diabetes mellitus discharge planning module, which was incorporated into the summary of diabetes self-care activity. The effectiveness of the intervention in improving the compliance of patients with self-care activity was also evaluated.

Materials and Methods:
This study used a mixed methodological approach, which combined an evaluation method and an experimental quantitative design. The content validity of the module used was carried out using professional judgment, involving competent experts in the bahteramas hospital in southeast Sulawesi, Indonesia. The sample population consisted of sixty-five randomly selected respondents, who participated in the validation of the summary of Diabetes Self-Care Activities (SDSCA) questionnaire, which had three phases, namely pre-test, during, fieldwork, and post-test.

Results:
The content validity of the module was tested using Aiken’s v, and the results ranged from 0.82 to 0.88 for each session, indicating that it was valid. Furthermore, the internal consistency (Cronbach’s alpha) obtained in this study was acceptable, with values ranging from 0.60 to 0.92.

Conclusions:
The results showed that the diabetes mellitus discharge planning module could be used to improve self-care among patients.
Artificial intelligence in psychiatric education: Enhancing clinical competence through simulation
Authors: Ajluni Victor 
Published: January 2025

ABSTRACT
The integration of artificial intelligence (AI) in psychiatric education offers transformative potential to enhance clinical competence through realistic simulations. Traditional educational methods face limitations in replicating complex psychiatric cases, and AI-based tools provide a scalable solution. This narrative review examines current evidence on the efficacy of AI-powered simulations, focusing on their role in skill development, diagnostic accuracy, and safe clinical training. Through a comprehensive literature review of studies from 2010 to 2024, key themes such as AI’s ability to standardize patient encounters, provide instant feedback, and improve student confidence are explored. Findings suggest that AI can enhance psychiatric education by offering consistent, adaptable learning experiences that prepare trainees for real-world complexities. However, challenges such as ethical considerations and accessibility disparities must be addressed for AI to be effectively integrated into psychiatric training. This review provides insights into the future of AI in medical education and its potential impact on training the next generation of psychiatrists.
Influence of mode of delivery on maternal and fetal outcomes in patients with preterm prelabor rupture of membranes
Authors: Midhuna K. S. , Vavaldas Umadevi , Kandhichetty Sarada 
Published: January 2025

Background:
Diagnosis and proper management are very important to limit various fetal and maternal complications. Preterm prelabor rupture of membranes (PPROM) early diagnosis and intervention decide the further fate of pregnancy. Maternal and fetal outcome in PPROM is very important to decrease maternal and child mortality and for better management and prevention of complications.

Objective:
The objective is to study the influence of the mode of delivery on maternal and fetal outcomes in patients with PPROM.

Materials and Methods:
The study was hospital-based prospective-Cohort study done among 204 cases with PPROM. Antepartum and intrapartum events were recorded. Based on the preference of the treating unit and existing hospital protocols, patients undergoing either of the three modes of delivery (cesarean, vaginal, cesarean after failed trial) were observed for maternal and fetal outcomes. Women between 28 and 36 weeks + 6 days period of gestation were divided into three groups. Group A: 10 women (cesarean section), Group B: 174 women (vaginal delivery), and Group C: 20 women (cesarean section after failed trial).

Results:
Majority women (>60%) in all three groups belonged to the gestational age of 34–36+6. The vaginal delivery group had the least proportion of neonatal complications at 32–33+6 weeks of gestation, and at 34–36+6 weeks of gestation. Sixty percent of women in the failed trial group had complications compared to 50% in the cesarean section group and only 18.9% of the women from the normal vaginal delivery group had complications. This difference was found to be statistically significant.

Conclusion:
Maternal and neonatal complications were significantly more in the failed trial group followed by the cesarean section group compared to the normal vaginal delivery group.
Isolation of Dental Caries Bacteria from Dental Plaque
Authors: Abdulhadi Ali Mohammed Hussein , Alghanim Kareem M. , Yassein Mustafa Mohsen , Khadir Hommam Mohammed , Abd Tiba Ahmed , Sahib Mariam Jassim , Raheem Zainab Ali 
Published: January 2025

Background : Dental caries stands out as a highly prevalent and preventable condition, identified as the leading contributor to oral discomfort and tooth loss. This condition represents a significant public health challenge that obstructs the attainment and preservation of oral health across all age demographics. The WHO has indicated that the global issue of oral disease continues to exist, even with significant advancements in the oral health of populations in various countries. Aim of study : Isolation of Dental Caries Bacteria from Dental Plaque and detection Pattern of resistance to common antibiotics in dental clinics. Methodology : Specimens collection include 75 clinical swabs (45 Male and 25 Female) isolated from dental caries patients who were admitted to Al-Kafeel teaching clinic and outpatient from dentist clinic in AL-Najaf City between November 2022 to January 2023 with age group between 30-70 years. All the specimens were labeled and transported Immediately by sterile transport swabs to the laboratory for Culture and Identification. For each patient, medical records were reviewed, which including name, gender, age, address, hospitalization, and antibiotic receiving. and immediately transport to the old . Results : The study comprised of 75 patients with dental caries , 45 patients were male while 30 patients were female , The swabs taken from dental clinics have been showed that 64 (85.3%) of specimens were gram positive bacteria and only 11 specimens (14.7%) were gram negative bacteria. The result showed that about 64 specimens from totally 75 were gram positive and the most common species were: Streptococcus mutans 20 (26.66%) , Staphylococcus aureus 15 (20%), Lactobacilli 10 (13.33%) , Staphylococcus species 8 (10.66%) , Streptococcus species 5 (6.66%) , Enterococcus faecalis 4(5.33%) , Bacillus species 2 (2.66%) and Micrococcus species 2 (2.66%). Gram negative bacteria that isolated from dental caries were only 11 . The bacterial species were : E. coli 3 (4%), K. pneumonia 2 (2.66%) , P. aeruginosa 2 (2.66%), Moraxella 1 (1.33%) and Acinetobacter baumannii 1 (1.33%). Tow specimens were unknown (2.66%) , Vitek 2 system had no results.
The Existence of Dowry Demands (Belis) and Marital Failure as Criminogenic Factors in the Occurrence of Criminal Provocative Abortions and Other Crimes in the City of Kupang
Authors: Leo Rudepel Petrus , Bunga Gerald Aldytia 
Published: January 2025

Objective: This study aims to explain the relationship between firmness in fulfilling dowry demands and marriage implementation, the relationship between marriage implementation and the occurrence of abortion and other crimes, and the current public attitude towards dowry demands in contemporary marriage affairs.

Method: This study uses quantitative and qualitative approaches. Data collection was done using questionnaires and interviews. The data were analyzed using frequency distribution tables and inferential statistical tests.

Results and Discussion: A significant relationship exists between firmness in fulfilling dowry demands and marriage implementation. The correlation coefficient between the two variables is "high" or "good." There is a significant relationship between marriage implementation and the occurrence of abortion cases and other crimes. The correlation coefficient between the two variables is "very high" or "very good." The community's attitude is willing to maintain the practice of dowry as it is now. The community's attitude is expected to be an implication of this research. The attitude of the community disagrees with the practice of dowry and is willing to remove the practice of dowry from marriage affairs in society.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the dowry can influence the practice of abortion in Kupang.

Originality/Value: This study provides a new understanding of how the Dowry demand can influence abortion. This study also encompasses the implementation of Dowry demands in marriage in Kupang.
Exploring gender-based disparities in emotional distress among university level athletes
Authors: Saha Sohom , Boby Farjana Akter , Sharma Arnav , Ganguly Sourav , Upadhyay Kautilya , Khati Awesh , Singh Dev Karan , Dhoni Kamal , Karmakar Debajit 
Published: January 2025

Introduction: The mental health of university level athletes is a growing concern, with female athletes facing unique emotional challenges that remain underexplored. Objective: This study aims to examine gender-based disparities in depression, anxiety, and stress among university-level volleyball, basketball, and handball players to understand sport-specific and gender-specific emotional dynamics. Methodology: A cross-sectional comparative design was used, involving 60 university athletes (30 males, 30 females) aged 18-25 from LNIPE, Gwalior. Emotional symptoms were assessed using the Depression, Anxiety, and Stress Scales (DASS-42). Independent t-tests and one-way ANOVA were employed to analyze gender and sport differences, with significance set at p < 0.05. Results: Results revealed distinct gender-based patterns: male volleyball players reported significantly higher levels of stress (mean score 24.80) and depression (mean score 17.60) compared to their female counterparts, while female basketball players exhibited greater depression (mean score 17.10) than males. Among handball players, females experienced significantly higher stress levels (mean score 19.70) compared to males. Discussion: The findings suggest gender-specific emotional responses to competitive sports, possibly influenced by societal expectations, coping strategies, and sport-specific stressors. Volleyball's individual performance components may increase stress for male athletes, while basketball's physical demands might elevate depression levels among females. Handball's continuous play and physical contact likely contribute to elevated stress in female players. Conclusions: Developing psychological support systems for university athletes can mitigate emotional challenges and optimize performance. Future research should explore longitudinal changes in emotional symptoms and their relationship with competitive dynamics.
Didáctica de la competencia conversacional en lenguas extranjeras: hacia un nuevo modelo secuencial-intercultural
Authors: Rivero Cruz Lizandra , Frómeta Quintana Elaine , Tardo Fernádez Yaritza 
Published: January 2025

El artículo analiza que los actuales enfoques sobre la didáctica de la competencia conversacional en lenguas extranjeras aún resultan descriptivos para el logro de una práctica conversacional espontánea, creativa y contextualizada en los estudiantes. Se propone un modelo teórico que integra la sistematización problematizadora de los temas conversacionales y la co-construcción del diálogo intercultural, desde una lógica didáctica coherente. Se presenta, además, una propuesta de acciones metodológicas que orientan al profesor en el desarrollo de la práctica conversacional en el aula de lenguas extranjeras. Se empleó el método holístico dialéctico en la concepción teórica del modelo y un estudio cualitativo de pequeña escala para comprobar la efectividad de su aplicación. Este estudio incluyó el Análisis de la Conversación como técnica para recolectar e interpretar los datos obtenidos a partir de un corpus oral creado ad hoc. El tratamiento de los datos se realizó con el software gratuito de procesamiento de corpus LancsBox, versión 6.0. Las acciones metodológicas propuestas tuvieron un efecto positivo en los estudiantes, quienes mostraron un mejor dominio de las estructuras secuenciales, interactivas, de cortesía y socioculturales. Los resultados sugieren que la sistematización didáctica de la estructura secuencial-temática de la conversación desde una interpretación contextualizada de las relaciones interculturales resulta un enfoque novedoso para los docentes en función de desarrollar la competencia conversacional en lenguas extranjeras. Por lo que se considera necesario continuar generalizando la propuesta a grupos de aprendices extranjeros de diferentes nacionalidades y lenguas maternas, como expresión de las potencialidades didácticas de estos resultados.