bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Unifying Concept for the Prebiotic Formation of RNA Pyrimidine Nucleosides
Authors: Feldmann Jonas , Skaanning Mads K. , Lommel Marcus , Kernmayr Tobias , Mayer Peter , Carell Thomas 
Published: March 2023

AbstractThe question of how nucleosides might have formed as essential precursor molecules on the early Earth is one of the many challenges associated with the origin of life. In this context, the prebiotic synthesis of pyrimidine nucleosides is controversially discussed. For the pyrimidines, two at first glance contradictory prebiotically plausible reaction pathways have been proposed, based on either oxazole or isoxazole chemistry. This study shows that these two reaction sequences can be merged under prebiotically reasonable conditions, suggesting that both pathways could have co‐existed and possibly interacted. The key precursor 3‐aminoisoxazole was found to react with the key intermediate of the oxazole route (ribo‐2‐(methylthio)oxazoline), to form a ribo‐isoxazole‐oxazoline hybrid structure, which collapses upon reductive N−O bond cleavage to give the nucleoside cytidine. The data suggest that different, interacting prebiotically plausible chemical pathways may have created the key molecules of life on the early Earth.
Summary of tillage practices in peanut in the Virginia–Carolina region of the United States
Authors: Jordan David L. , Shew Barbara B. , Brandenburg Rick L. , Anco Dan , Balota Maria 
Published: March 2023

Core Ideas
Deep tillage in the form of moldboard plow decreased in peanut in North Carolina from 1998 to 2018.
Reduced tillage was adopted by more peanut farmers in South Carolina and Virginia than in North Carolina.
More farmers strip‐tilled peanut across all states rather than no till.
Excitation‐Wavelength‐Dependent Luminescence of Chemically and Physically Mixed Europium and Terbium Phosphonates: Color‐Tunable Luminescence, Near‐White‐Light Emission, and Selective Fe3+ Detection
Authors: Hu Zhi‐Jia , Tsai Meng‐Jung , Tu Yi‐Jung , Wu Jing‐Yun 
Published: March 2023

AbstractMolecular lanthanide phosphonates [Ln2(H3tpmm)2(H2O)6] ⋅ xH2O (Ln=Eu, EuP; Ln=Tb, TbP) were synthesized. Single‐crystal X‐ray diffraction confirmed that EuP has a sandwich‐like dinuclear structure, in which the Eu(III) center adopts a {EuO8} distorted dodecahedral geometry. XRPD patterns prove that TbP and EuP are isomorphous and isostructural. EuP and TbP are highly thermally stable approaching 450 °C and exhibit red‐ and green‐light emissions from the characteristic 4 f–4 f transition of the Eu3+ and Tb3+, respectively. Interestingly, luminescence modulation is achieved for the chemically mixed Eu/Tb phosphonate analogues, c‐EuxTb2–xP (x=1.5, 1, 0.5), and physically mixed Eu/Tb phosphonate materials, p‐yEuP : zTbP (y : z=3 : 1, 1 : 1, 1 : 3), with varying the excitation wavelength. Of particular note, near‐white‐light emission is also achieved for c‐EuTbP, p‐EuP : TbP, and p‐EuP : 3TbP when excited at 365 nm. Therefore, these dinuclear molecular lanthanide phosphonates emitting excitation wavelength and Eu3+ : Tb3+ ratio dependent luminescence might be potential candidates for color‐tunable luminescence materials and white‐light‐emitting materials. On the other hand, the bright green‐light emission makes TbP to be an excellent reusable luminescence sensor for selective detection of Fe3+ with Stern‐Volmer quenching constant (KSV) of 9.66×103 M−1 and detection limit (DL) of 0.42 μM through absorption competition caused luminescence quenching effect.
Radiation‐Responsive Benzothiazolines as Potential Cleavable Fluorogenic Linkers for Drug Delivery
Authors: Tuo Wei , Renault Jean‐Philippe , Rajpal Aashini , Pin Serge , Le Gall Thierry , Taran Frédéric 
Published: March 2023

AbstractRadiosensitive compounds can be useful for the detection of radiations and also as prodrugs that can be activated during a radiotherapy. Herein we describe the use of benzothiazolines, which upon treatment with 137Cs produced γ‐irradiation in water give rise to fluorescent benzothiazoles and concomitant release of amines or carboxylic acids. In a proof of concept study, we showed that benzothiazolines may be used as new cleavable linkers that can be triggered upon irradiation.
Chalcogen Atom Size Dictates Stability of Benzene‐1,3,5‐triamide Polymers: Overlooked Role of Geometrical Fit for Enhanced Hydrogen Bonding
Authors: Nieuwland Celine , Lekanne Deprez Siebe , de Vries Claris , Fonseca Guerra Célia 
Published: March 2023

AbstractOur quantum chemical analyses elucidated how the replacement of O in the amide bonds of benzene‐1,3‐5‐tricarboxamides (OBTAs) with the larger chalcogens S and Se enhances the intermolecular interactions and thereby the stability of the obtained hydrogen‐bonded supramolecular polymers due to two unexpected reasons: i) the SBTA and SeBTA monomers have a better geometry for self‐assembly and ii) induce stronger covalent (hydrogen‐bond) interactions besides enhanced dispersion interactions. In addition, it is shown that the cooperativity in benzene‐1,3,5‐triamide (BTA) self‐assembly is caused by charge separation in the σ‐electronic system following the covalency in the hydrogen bonds.
Study of Shell Growth Processes of Copper Iron Selenide‐based Near‐infrared Emitting Nanocrystals
Authors: Sugathan Anumol , Tomar Nitin , Rajasekar Guru Pratheep , Anshu Ashwini , Pandey Anshu 
Published: March 2023

AbstractCore/shell growth in nanosystems is usually accomplished either through deposition of the shell material or else through the conversion of a part of the core into the shell through ion exchange. Here we describe the interplay of both deposition processes in the case of CuFeSe2/CdS nanocrystals. Specifically, we synthesize eskebornite CuFeSe2 nanoparticles. Films of the nanocrystals exhibit an optical absorbance onset of 0.11 eV. Core/shell structures prepared from CuFeSe2 show a unique dependence on the growth steps followed. In particular, we find that the addition of the cationic precursor before the anionic precursor leads to the formation of CdSe at the interface of the core and the shell. This is found to limit the tunability of the emission to 820 nm. In contrast, reversing the order of precursor addition prevents the formation of such a layer and leads to structures with a significantly greater emission tunability (900 nm to 1200 nm). Our observations are suggestive of the interplay of both processes in current syntheses for I‐III‐VI2 based core/shell structures.
The Alchemist, Metal‐Divider and Transmuter Carl F. Wenzel and his 1776 Award from the Royal Danish Academy of Sciences through Professor C. G. Kratzenstein
Authors: Wentrup Curt 
Published: March 2023

AbstractC. F. Wenzel was a chemist and an alchemist. He had deep knowledge of acids, bases and salts, and he was credited with the first formulation of the Law of Mass Action. Yet he was also an alchemist, who on the eve of the Chemical Revolution published his beliefs in transmutation and in the division of metals into their constituents, for which he was rewarded with the gold medal of the Royal Danish Academy of the Sciences. His promoter, Professor C. G. Kratzenstein, was himself a believer in transmutation, even if he voiced some reservations.
Protective effect of antioxidant peptides from bass (Lateolabrax japonicus) on oxidative stress injury in Caco‐2 cells
Authors: Li Chen , Chen Xu , Li Lichan , Cheng Jing , Chen Huimin , Gao Qun , Yang Fujia , Cai Xixi , Wang Shaoyun 
Published: March 2023

AbstractExcessive reactive oxygen species (ROS) can induce oxidative damage to cell membranes and biomolecules, leading to various chronic diseases. Therefore, the exploration of effective natural antioxidants that can replace traditional synthetic antioxidants to reduce excess free radicals without side effects is important. Herein, the antioxidant peptide (Lateolabrax japonicus protein hydrolysates; LPH) was obtained from bass (L. japonicus) by an optimal enzymatic hydrolysis process. The protective effect of LPH on the Caco‐2 cell oxidative stress model and the potential antioxidant signaling pathways were explored. The results showed that LPH was rich in hydrophobic amino acids, and the IC50 for 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging activity was 0.9667 mg/mL. Furthermore, the LPH treatment reduced cellular ROS levels and lipid peroxidation while increasing antioxidant enzyme activity in a dose‐dependent manner (p < .05). LPH also upregulated the expression of mRNAs related to antioxidant enzymes in the Nrf2 signaling pathway (p < .05), demonstrating the efficacy of LPH on the Nrf2–ARE signaling pathway. These results suggested that LPH could be used as a potential food‐derived antioxidant in the food and healthcare industries.
The nutritional quality and contents of heavy elements due to thermal processing and storage in canned Thunnus tonggol fish change compared to fresh fish
Authors: Aberoumand Ali , Baesi Ferideh 
Published: March 2023

AbstractThe purpose of this study was to evaluate the nutritional quality and concentration of heavy and toxic metals in the fresh and canned tuna Thunnus tonggol at different storage periods. The content of iron, zinc, copper, mercury, and also macronutrient compounds in the Iranian fresh and canned tuna fish and the effects of thermal processing and subsequent storage on metal contents were evaluated using atomic absorption spectroscopy. The results showed that the levels of iron, zinc, copper, and mercury after the 6th, 9th, and 11th months of storage were 26.52, 10.83, 6.22, and 0.04 mg/kg, respectively. The concentrations of iron, zinc, copper, and mercury in the fresh fish were 11.03, 7.11, 1.71, and 0.03 mg/kg, respectively. The results of the statistical analysis of the samples showed that canning process and sterilization by autoclave increased the contents of elements except mercury to a significant level (p < .05). The results showed that the amount of fat significantly increased in all samples after storage (p < .05), but the ash and protein content significantly decreased (p < .05). The moisture content significantly increased (p < .05) except for the 9th month of storage. The obtained results showed that the energy value after 6 months of storage was the highest (297.53 kcal/100 g). The results showed that the bioaccumulation of copper, iron, zinc, and mercury in the fresh and canned muscles was lower than the standard concentration recommended by the FAO and WHO. This type of fish was a high‐quality food source and it was safe after 11 months of storage and was suitable for human consumption. Therefore, the consumption of Iranian canned tuna can be safe for human health despite the possible contamination with heavy metals.
The impact of performance‐based financing within local health systems: Evidence from Mozambique
Authors: Anselmi Laura , Ohrnberger Julius , Fichera Eleonora , Nhassengo Pedroso , Fernandes Quinhas F. , Chicumbe Sergio 
Published: March 2023

AbstractMost evidence on Performance Based Financing (PBF) in low‐income settings has focused on services delivered by providers in targeted health administrations, with limited understanding of how effects on health and care vary within them. We evaluated the population effects of a program implemented in two provinces in Mozambique, focusing on child, maternal and HIV/AIDS care and knowledge. We used a difference‐in‐difference estimation strategy applied to data on mothers from the Demographic Health Surveys, linked to information on their closest health facility. The impact of PBF was limited. HIV testing during antenatal care increased, particularly for women who were wealthier, more educated, or residing in Gaza Province. Knowledge about transmission of HIV from mother‐to‐child, and its prevention, increased, particularly for women who were less wealthy, less educated, or residing in Nampula Province. Exploiting the roll‐out by facility, we found that the effects were concentrated on less wealthy and less educated women, whose closest facility was in the referral network of a PBF facility. Results suggest that HIV testing and knowledge promotion increased in the whole district, as a strategy to boost referral for highly incentivized HIV services delivered in PBF facilities. However, demand‐side constraints may prevent the use of those services.
Ultrasmall barium titanate nanoparticles modulated stretchable dielectric elastomer sensors with large deformability and high sensitivity
Authors: Feng Zun‐Peng , Hao Ya‐Nan , Qin Jing , Zhong Shao‐Long , Bi Ke , Zhao Yu , Yin Li‐Juan , Pei Jia‐Yao , Dang Zhi‐Min 
Published: March 2023

AbstractLarge deformability and high sensitivity is difficult to be realized simultaneously in flexible sensors. Herein, taking advantage of the high permittivity and highly active surfaces of the ultrasmall barium titanate nanoparticles (BT NPs) and the high stretchability of the p(BA‐GMA) elastomer matrix, we propose a high‐performance soft stretchable sensor. The addition of the ultrasmall BT NPs can not only increase the permittivity and capacitance of polyacrylate‐matrix composite dielectric material to obtain a high sensitivity, but also basically maintains the excellent mechanical properties of the polymer matrix. The dielectric constants of the composite films increase from 5.68 to 13.13 at 10 kHz with the increase of BT NPs content from 0 to 15 vol.%, which results in a high capacitance of 236.16 pF for 15 vol.% BT/p(BA‐GMA) sensor. Combining the high permittivity and the large deformability (a maximal deformation of 87.2%), the 15 vol.% BT/p(BA‐GMA) sensor has high sensitivity and shows high linearity and stable output even if under dynamic measurement. The dual‐mode sensor that utilizes the orthogonality of capacitance‐resistance is designed, which shows excellent performance in monitoring human body movements and noncontact measurement. The results present that the BT/p(BA‐GMA)‐based sensor has high stability and reliability not exceed 65°C, which can meet the application requirements in dynamic monitoring.image
Estimation of misreporting probability in corporate credit rating: A nonparametric approach
Authors: Lu Ruichang , Luo Yao , Xiao Ruli 
Published: March 2023

AbstractThere has been heated debate regarding credit‐rating agencies' (CRAs') reporting accuracy of corporate credit ratings, which is essential for investors because they rely on those crediting ratings to make investment decisions. We estimate the reporting accuracy using the data on corporate ratings from Standard & Poor from January 1986 to December 2011. First, there is a U‐shape in the overall misreporting pattern: the left‐hand side (the high‐rating groups) has a lower misreporting probability (3%), the middle has no misreporting, and the right‐hand side has a high misreporting probability (6%). Second, we find that there is a significant difference across the industries. The financial sector has the highest misreporting probability (35% in the lowest rating group) and misreporting magnitude (rating rank jump between true rating and reported rating), and the energy industry has the lowest misreporting probability. Last, when the economic condition is good, CRAs are likelier to inflate the rating.
Latent profile analysis of adolescent temperament: Relations to happiness and health in adulthood
Authors: Guerin Diana Wright , Gottfried Allen W. , Preston Kathleen S. J. , Gottfried Adele Eskeles , Ramos Michelle C. , Oliver Pamella H. , Cheng Chia‐Hsin Emily , Riggio Ronald E. 
Published: March 2023

AbstractIntroductionThis study provides long‐term evidence that profiles of temperament during adolescence are associated with happiness and health over two decades later.MethodsData are based on the ongoing Fullerton Longitudinal Study, a community‐based sample in the United States. At 14 and 16 years, adolescents (N = 111; 52% male, 90% Euro‐American) and their mothers (N = 105) completed the Dimensions of Temperament Survey‐Revised, a scale designed specifically to assess adolescents' temperament across a set of attributes. When adolescents reached age 38 years in 2017, they completed scales measuring comprehensive happiness and global health.ResultsLatent profile analysis (LPA), a person‐centered approach, was conducted for adolescents' and for mothers' temperament ratings separately. Distinct two‐profile solutions, labeled more regulated and less regulated, emerged for each informant. These were comparable in features across informants. Only the adolescents' self‐rated profiles, controlling for sex and family SES, revealed a conceptually meaningful and statistically significant relation to the distal outcomes of health and happiness two decades later.ConclusionsAdolescents with temperament profiles characterized as more regulated, in contrast to less regulated, reported being happier and healthier upon entering middle adulthood. Implications for intervention are presented.
Behavioral health services in Urban American Indian Health Programs: Results from six site visits
Authors: Pomerville Andrew , Wilbur Rachel E. , Pham Tony V , King Cheryl A. , Gone Joseph P. 
Published: March 2023

AbstractThis study explores behavioral health services for American Indians and Alaska Natives (AIANs) at six Urban Indian Health Programs (UIHPs). Interviews and focus groups with clinicians and staff inquired about behavioral health treatment available, service needs, client population, and financial and staffing challenges. Resulting site profiles were created based on focused coding and integrative memoing of site visit field notes and respondent transcripts. These six UIHPs evidenced diversity across multiple facets of service delivery even as they were united in their missions to provide accessible and effective behavioral health treatment to urban AIAN clients. Primary challenges to service provision included heterogenous client populations, low insurance coverage, limited provider knowledge, lack of resources, and incorporation of traditional healing. Collaborative research with UIHPs harbors the potential to recognize challenges, identify solutions, and share best practices across this crucial network of health care sites for improving urban AIAN well‐being.
Extraction and separation studies of Nd/Fe and Sm/Co by deep eutectic solvent containing Aliquat 336 and glycerol
Authors: Prusty Susmita , Pradhan Sanghamitra , Mishra Sujata 
Published: March 2023

AbstractBACKGROUNDIn today's technologically developed society, the demand for materials with enormous applications in electrical and electronic devices has been sharply increasing. Rare earths, like neodymium and samarium, are two of these high‐demand materials. Their widespread use as permanent magnets in association with some transition metals (like iron and cobalt) has created the need to design novel and environmentally benign pathways for their extraction and separation.RESULTSThe present work demonstrates the use of a novel deep eutectic solvent (DES) synthesized from Aliquat 336 and Glycerol diluted in kerosene for the solvent extractive separation studies of Nd/Fe and Sm/Co from nitrate medium. The variations in thermophysical attributes (like density, dielectric permittivity, and refractive index) provide insight on their extraction behavior, DES efficiency, and separation feasibility. Effects of variable experimental conditions, like pH, mixing time, temperature, DES molarity, nitrate concentration, and phase volume ratio, on separation have been examined. Complete separations of Nd(III)/Fe(III) and Sm(III)/Co(III) were achieved under multiple extraction conditions. Using the organic to aqueous phase volume ratio (O/A) ratio = 2:1 (pH = 2, [NaNO3] = 3.5 M, [DES] = 0.2 M, T = 298 K), the highest extraction percentage of Nd(III) was found to be 93.8%, and with O/A = 4:1(pH = 2, 2 M NaNO3, 0.2 M DES, 298 K), that of Sm(III) was 93.6%. Stripping was 100% for Nd and Sm using 0.6 M HCl.CONCLUSIONAli‐Gly DES diluted in kerosene showed the highest selectivity for Nd, then for Sm, followed by Fe. It did not extract cobalt under the considered conditions. A lower time consumption, room temperature separation, and the low concentration of DES used are the major findings of the present research work. © 2023 Society of Chemical Industry (SCI).
Product sieving of mAb and its high molecular weight species in different modes of ATF and TFF perfusion cell cultures
Authors: Pappenreiter Magdalena , Schwarz Hubert , Sissolak Bernhard , Jungbauer Alois , Chotteau Véronique 
Published: March 2023

AbstractBACKGROUNDTangential flow filtration (TFF) systems are widely used cell retention devices in perfusion cultures, but significant challenges occur with their prolonged operation. A well‐known and common issue includes membrane fouling, which leads to reduced permeate flow and increased product retention. The fouling behavior in hollow fibers have been studied widely and the application of alternating flow profiles, cell lysis, shear stress, and membrane pore size have been found to be major contributors to this phenomenon.RESULTSIn this work, different process set ups and conditions were tested using magnetic levitation pumps for low shear TFF systems in small‐scale perfusion bioreactors (200 mL). A novel concept based on the application of reverse flow across the hollow fiber using two magnetically levitating pumps was validated with a Chinese Hamster Ovary cells (CHO) cell line producing a recombinant monoclonal antibody. Product sieving could be improved by 30% when a dynamic recirculation flow was applied. Furthermore, minimal product retention was achieved by reversing the flow of two alternating pumps with short cycle times. Besides this, a correlation was found between the passage of high molecular weight species to the harvest stream of the perfusion process and the flow direction, as well as the degree of product sieving.CONCLUSIONTFF with a reverse flow is a valuable alternative to an alternating tangential flow (ATF) system for overcoming antibody retention and it can be used at various scales and at a constant bioreactor volume. The comparison of ATF and TFF showed differences in product yield and purity and is, therefore, an important point for process design. © 2023 The Authors. Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).