bluuebunny/crossref_metadata_2025_split huggingface dataset:
LACC1: A critical involvement in macrophage immunometabolism
Authors: Li Yaling , Wu Zhixiong , Tan Xiaoli , Tang Liang , Ouyang Fan 
Published: June 2023

AbstractLaccase domain‐containing 1 (LACC1) protein is an enzyme highly expressed in inflammatory macrophages, and studies have shown that it has a key role in diseases such as inflammatory bowel disease, arthritis, and microbial infections. Therefore, in this review, we focus on LACC1‐mediated catalysis. In detail, LACC1 converts l‐CITrulline (l‐CIT) to l‐ORNithine (l‐ORN) and isocyanic acid in mice and humans and acts as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism, thus exerting anti‐inflammatory and antibacterial effects. Considering the actions of LACC1, targeting LACC1 may be a potent therapeutic avenue for inflammation‐related diseases and microbial infection diseases.
Uniquely called: African American community college presidents promoting equitable student success
Authors: Davis Jemilia S. , Greenlee Jacqueline 
Published: June 2023

AbstractBlack community college presidents are not exempt from racialized experiences as they promote equitable student success. This study explores the unique experiences of Black leaders who advocate for policies, practices, and procedures that promote equity and social justice at their institutions and in their communities. Together, applied critical leadership (ACL) and the principles of critical race theory (CRT) underpin the research study presented in this chapter and helped inform the interview protocol and identify strategies the presidents use to promote equitable change. In this chapter, five African American presidents share how they conceptualize equity‐driven leadership and how their racialized identities inform their approaches to improving equitable outcomes for all students, particularly students of color. Presidents shared strategies that any community college leader can use to demonstrate their commitment to social justice and advance the practice broadly.
Gatekeepers to the community college presidency for leaders of color
Authors: Hines CharMaine Y. 
Published: June 2023

AbstractResearch has identified a clear underrepresentation of race and gender diversity in the community college presidency and scant progress in diversification. This phenomenological study used critical race theory (CRT) and glass ceiling theory (GCT) lenses to examine the lived experiences of minority community college presidents, including those who identified as African American, Asian Pacific Islander, and Latino/Hispanic and spanned 12 states and every region of the U.S. The counter‐narratives of the participants were examined using a modified interpretative phenomenological approach concept model with cultural domain analysis (CDA) for validation. Participants were categorized by generational definitions and their associated community college development leadership styles. Findings include evidence of a leaky pipeline, a flawed hiring process with gatekeepers along the hiring continuum, and biases and stereotypes encountered, illustrating leaders’ perceptions of underrepresentation of minorities serving in presidential roles in community colleges. The study identified numerous deficiencies impacting this underrepresentation and offered recommendations to improve practice.
Asian American women leading transformatively
Authors: Leung Amy , Turner Caroline S. 
Published: June 2023

AbstractThis chapter provides critical insights into transformative leadership, a leadership approach guided by equity, social justice, and emancipatory education, based on the practices of eight Asian American women in community college administration. The authors engaged in critical narrative inquiry and conducted semi‐structured interviews with each leader. The study findings revealed leadership practices that center the democratic mission of the community college, social justice, community, and activism. Themes of the Asian American woman identity, intersectionality, and multiplicity also emerged from the narrative data. The chapter serves to underscore the assets these leaders bring to their educational institutions and debunk negative stereotypes of Asian American leadership.
Hiring and cultivating equity and social justice‐committed community college presidential assistants
Authors: Harper Jordan 
Published: June 2023

AbstractPresidential assistants are important and trusted staff members to the president and the campus community at large. Despite their importance, little is known about the day‐to‐day of their jobs and how they may help advance equity and social justice goals and priorities at the community college level. This chapter attempts to rectify this gap through document analysis of publicly available job announcements and descriptions for presidential assistants. Thereafter, recommendations for both hiring and professional development are presented to ensure that presidential assistants arrive with and are developing the necessary skills and competencies to be involved in shared leadership work towards equity and social justice.
The application of a racial equity and social justice framework to examine community college leadership
Authors: Rodriguez Francisco C. , Escobar Claudia 
Published: June 2023

AbstractThe national demand for social justice, racial equality, and criminal justice reform rightfully and painfully continues to sweep the consciousness of this nation. Community colleges were founded on educational excellence, opportunity, and access and should reflect principles of equity, justice, and community. This mission calls upon us, the most egalitarian institutions, to lead by example by making structural and permanent changes to root out the ill effects of racism and bias from our classrooms, curriculum, and workplace. In this paper, we examined equity‐minded leadership, culture, and climate at the Los Angeles Community College District, the nation's largest, and their efforts to transform their institutions, guided by their Framework for Racial Equity and Social Justice. The Framework speaks to the values of the District and directs specific action steps and commitments that will allow the colleges and District to actively build anti‐racist organizational capacity and resilience and move forward towards a more socially and racially‐just academic community.
Emphasizing equity amid transformational change at community colleges
Authors: Knight C. Ryan 
Published: June 2023

AbstractIncreasingly, community colleges recognize the need to center transformational change on equity. This chapter presents findings from a multi‐site qualitative case study on how community college presidents and chancellors can keep equity at the forefront of the transformational change process. The three community college presidents and chancellors participating in this study reflected on how their colleges—all 2019 Aspen Prize finalists or winners—adopted an equity lens to guide their change efforts and guided sensemaking among their campus members to challenge existing institutional logics and develop an equity‐minded culture. This study found that community college leaders should: (a) lead their colleges in equity sensemaking; (b) embed student success and equity within their institutional mission; (c) leverage data and policies to increase equity; and (d) provide professional development for college leaders, faculty, and staff around equity and social justice.
Mobilizing theory to application: Equity‐driven and social justice‐oriented leadership in community colleges
Authors: Burmicky Jorge , Hartman Catherine 
Published: June 2023

AbstractIn this final chapter, we reflected on the collective works presented in this volume by a diverse group of community college scholars and leaders. Through this reflection, we share how this scholarship sought to operationalize and enhance the definitions of equity‐driven and social justice‐oriented leadership in community colleges. After introducing these definitions, we provide applications for how community college leaders can adopt equity‐driven and social justice‐oriented leadership to their scholarship and practice. We conclude this chapter by providing reflective questions for readers to be able to mobilize equity and social justice to their daily practice. Furthermore, we provide reflective questions to apply these principles at the institutional, systems, and policy level practice.
Simultaneous transvenous lead extraction and implantation of leadless cardiac pacemaker: A case report
Authors: Wu Mengwei , Su Hao 
Published: June 2023

AbstractCardiovascular implantable electronic device (CIED) infection is a serious complication and remains the most common indication for transvenous lead extraction (TLE). In addition, there are serious challenges such as venous access occlusion and reinfection after extraction. Leadless pacemaker (LP) provides a safe and effective pacing option for patients with device‐related infections. We describe here a case of simultaneous transvenous lead extraction and leadless pacemaker implantation due to bilateral venous infection and pacing dependency.
Actinomycetoma distal radius mimic osteosarcoma: A case report of a rare presentation
Authors: Elbahri Hassan , Alnaser Adnan Ayman Mohammed Adnan , Babiker Sawsan A. M. , Mohamed Alaa Hatim Ameer 
Published: June 2023

Key Clinical MessageActinmomycetma is a granulomatous infection with a presentation was very similar to osteosarccoma. Multidisciplinary team and triple assessments are extremely important to prevent misdiagnosis, surgical treatment in combination with medical treatment followed by regular clinical and radiological follow‐up can be a limb‐saving procedure in such cases.AbstractVarious conditions may mimic osteosarcoma. The differential diagnosis of osteosarcoma is broad; Includes tumors, infection, trauma, and inflammatory processes arising from the musculoskeletal system. A proper history, examination, diagnostic imaging studies, and pathological analysis are essential to establish a precise diagnosis. This case report serves to illustrate the significance of recognizing the similarities between these two lesions and other rare features that will help to differentiate between actinomycetoma and osteosarcoma, to prevent late or misdiagnosis.
Giant pulmonary artery aneurysm in a child: Rare complication of congenital heart disease
Authors: Hailu Samuel Sisay , Derbew Hermon Miliard , Zeray Abrehet , Hailemariam Tesfahunegn , Otero Hansel J. 
Published: June 2023

Key Clinical MessageThis case report aims to increase awareness that pulmonary artery aneurysms may occur as a complication of neglected patent ductus arteriosus and should be sought in children with ill‐treated congenital heart diseases.AbstractPulmonary artery aneurysm is a rare anomaly with an autopsy prevalence of 1:14,000. These aneurysms can arise secondary to various etiologies, with congenital causes identified in 25% of cases and congenital heart diseases (CHD) responsible for more than half of these cases. A 12‐year‐old boy with CHD in the form of patent ductus arteriosus (PDA) and irregular clinical follow‐up presented with new onset fatigue of 3 months duration. A physical examination revealed anterior chest wall bulging and a continuous murmur. A chest radiograph showed a smooth left hilar region opacity that has a close relation with the left cardiac border. Transthoracic echocardiogram shows no progression from the previous one; there was a large PDA and pulmonary hypertension, but no further information was available. Computed tomography angiography revealed a giant aneurysm of the main pulmonary artery (PA), with a maximum diameter of 8.6 cm, and dilatation of its branches of 3.4 and 2.9 cm for the right and left PA, respectively.
What should be done when appropriate antiplatelet therapy fails to prevent stent thrombosis? Two case reports
Authors: Hong Sungman , Song Jaegyok , Ji Sung mi , Lee Wonkyu 
Published: June 2023

Key Clinical MessageWhen performing noncardiac surgery in high‐risk patients with PCI, anesthesiologists should be prepared for in‐stent thrombosis, that do not respond to conventional treatments and cardiopulmonary resuscitation. VA‐ECMO is an advantageous treatment method in those patients.
Copper‐Catalyzed Asymmetric 1,4‐Aryl/Alkynylation of 1,3‐Enynes to Access Axially Chiral Tetrasubstituted Allenes
Authors: Huang Han , Zhang Haiyan , Wang Qiaoling , Sun Youwen , Su Lei , Xu Wenru , Ma Yi , Kong Sheng , Zhang Guozhu , Guo Rui 
Published: June 2023

AbstractThe asymmetric 1,4‐difunctionalization of 1,3‐enynes represents a concise and highly efficient strategy for the preparation of chiral allenes. Herein, we developed a copper‐catalyzed three‐component asymmetric radical 1,4‐aryl/alkynylation of 1,3‐enynes by employing inexpensive, readily available, and highly reactive diaryliodonium salts as precursors to generate aryl radicals. The success of this reaction relied on the use of iminophenyl oxazolinylphenylamines (IPOPA) as chiral ligands. The reaction exhibited good compatibility with various alkynes, 1,3‐enynes, and diaryliodonium salts, providing an effective method for constructing highly enantioselective tetrasubstituted axially chiral allene compounds.
Fabrication of CZTS Films through a Combined Electrodeposition and Solution Process: An Experimental and First‐Principles Study
Authors: Katirci Ramazan , Onel Mehmet Nurullah , Danaci Ilhan , Danaci Kevser Irem , Ozbay Salih , Erden Fuat 
Published: June 2023

AbstractSulfurization has a critical role in preparation of CZTS films since the main drawback of CZTS is due to the presence of S‐based impurities. In general, sulfurization could be performed during or following annealing, or the entire CZTS structure could be prepared through sol‐gel. However, toxic gases are used for the former, and the latter takes prolonged times. Alternatively, a combined electrodeposition and solution process was proposed in the present work to prepare CZTS. Briefly, we electrodeposited CZT layers on a metal substrate, and then immersed the as‐prepared coating in a S containing solution for the sulfurization. The effects of electrodeposition time, electrodeposition order, current density, electrolyte compositions, sulfurization time, and annealing pressure were studied. Overall, the results show that S content of the films varied between 27 and 52 % depending on process parameters, thus, suggesting the effectiveness of the proposed approach regarding sulfurization. However, various secondary phases were also detected as well as considerable amount of oxygen impurity. Accordingly, we opted for a computational approach to elucidate the effect of oxygen impurities, and report that the band gap of the films varied between 0.59 and 0.05 eV depending on the presence and which sites oxygen atoms occupy.
Preparation of Buffered Nano‐Submicron Hierarchical Structure Hollow SiOx@C Anodes for Lithium‐Ion Battery Materials with Carboxymethyl Chitosan
Authors: Liu Tao , Wu Borong , Zhang Yuanxing , Mu Daobin , Li Ning , Su Yuefeng , Zhang Ling , Liu Qi , Wu Feng 
Published: June 2023

AbstractSilicon‐based materials are among the most promising anode materials for next‐generation lithium‐ion batteries. However, the volume expansion and poor conductivity of silicon‐based materials during the charge and discharge process seriously hinder their practical application in the field of anodes. Here, we choose carboxymethyl chitosan (CMCS) as the carbon source coating and binding on the surface of nano silicon and hollow silicon dioxide (H−SiO2) to form a hierarchical buffered structure of nano‐hollow SiOx@C. The hollow H−SiO2 can alleviate the volume expansion of nano silicon during the lithiation process under continuous cycling. Meanwhile, the carbon layer carbonized by CMCS containing N‐doping further regulates the silicon's expansion and improves the conductivity of the active materials. The as‐prepared SiOx@C material exhibits an initial discharge capacity of 985.4 mAh g−1 with the decay rate of 0.27 % per cycle in 150 cycles under the current density of 0.2 A g−1. It is proved that the hierarchical buffer structure nano‐hollow SiOx@C anode material has practical application potential.
Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties
Authors: Ņikitjuka Anna , Žalubovskis Raivis 
Published: June 2023

AbstractThe synthetic approaches towards unique asparagusic acid and its analogues as well as its chemical use, the breadth of its biological properties and their relevant applications have been explored. The significance of the 1,2‐dithiolane ring tension in dithiol‐mediated uptake and its use for the intracellular transport of molecular cargoes is discussed alongside some of the challenges that arise from the fast thiolate‐disulfide interchange. The short overview with the indication of the available literature on natural 1,2‐dithiolanes synthesis and biological activities is also included. The general review structure is based on the time‐line perspective of the application of asparagusic acid moiety as well as its primitive derivatives (4‐amino‐1,2‐dithiolane‐4‐carboxylic acid and 4‐methyl‐1,2‐dithiolane‐4‐carboxilic acid) used in clinics/cosmetics, focusing on the recent research in this area and including international patents applications.
Insights into the Pharmacological Activity of the Imidazo−Pyrazole Scaffold
Authors: Spallarossa Andrea , Rapetti Federica , Signorello Maria Grazia , Rosano Camillo , Iervasi Erika , Ponassi Marco , Brullo Chiara 
Published: June 2023

AbstractIn previous studies, we synthesized different imidazo−pyrazoles 1 and 2 with interesting anticancer, anti‐angiogenic and anti‐inflammatory activities. To further extend the structure‐activity relationships of imidazo−pyrazole scaffold and to identify novel antiproliferative/anti‐inflammatory agents potentially active with multi‐target mechanisms, a library of compounds 3–5 has been designed and synthesized. The chemical modifications characterizing the novel derivatives include: i) decoration of the catechol ring with groups with different electronic, steric and lipophilic properties (compounds 3); ii) insertion of a methyl group on C‐6 of imidazo−pyrazole scaffold (compounds 4); iii) shift of the acylhydrazonic substituent from position 7 to 6 of the imidazo−pyrazole substructure (compounds 5). All synthesized compounds were tested against a panel of cancer and normal cell lines. Derivatives 3 a, 3 e, 4 c, 5 g and 5 h showed IC50 values in the low micromolar range against selected tumor cell lines and proved to have antioxidant properties, being able to inhibit ROS production in human platelet. In silico calculation predicted favourable drug‐like and pharmacokinetic properties for the most promising compounds. Furthermore, molecular docking and molecular dynamic simulations suggested the ability of most active derivative 3 e to interact with colchicine binding site in the polymeric tubulin α/tubulin β/stathmin4 complex.
The highs and lows of serous ovarian cancer
Authors: Grisham Rachel N. , Manning‐Geist Beryl L. , Chui M. Herman 
Published: June 2023

AbstractLow‐grade serous ovarian cancer was initially described as a distinct type of rare epithelial ovarian cancer 20 years ago; however, only recently have physicians begun to leverage the understanding of the clinical behavior and molecular profile of this disease for treatment. The use of routine next‐generation sequencing has allowed a deeper understanding of the molecular drivers of this disease and shown how molecular alterations in mitogen‐activated protein kinase pathway genes such as KRAS and BRAF can affect overall prognosis and disease behavior. The use of targeted therapies, including MEK inhibitors, BRAF kinase inhibitors, and other investigational targeted therapies are changing the way this disease is viewed and treated. In addition, endocrine therapy can provide prolonged disease stability with generally mild toxicity, as well as promising response rates in recent studies examining combination therapy with CDK 4/6 inhibitors in the upfront and recurrent setting. Once seen merely as a chemo‐resistant form of ovarian cancer, recent studies have worked to harness the unique features of low‐grade serous ovarian cancer to provide individualized treatment options for patients with this disease.
Research on the masking effect of vertical interlock on ESG greenwashing in the context of sustainable Enterprise development
Authors: Liu Guangrui , Qian Hao , Wu Qianqian , Han Fei 
Published: June 2023

AbstractBased on impression management and principal‐agent theory, this article considers Chinese A‐share listed companies from 2014 to 2020 to explore whether vertical interlocking promotes the sustainable development of enterprises from the perspective of environmental, social, and governance (ESG) report greenwashing. The results show that vertical interlocking increases ESG report greenwashing and hides negative ESG information; these results remained valid through a series of robustness tests. Mechanism analysis shows that the purpose of ESG report greenwashing by vertically interlocked executives is to hollow out minority shareholders rather than to cover up earnings management to conceal actual ESG information. The vertical interlocking of executives more significantly promotes ESG report greenwashing when the property is state‐owned, has poor internal supervision mechanisms, has a large executive team and has no senior executives with green experience. This study furthers the relevant research on the factors affecting the sustainable development of enterprises and enriches and expands studies of the role of the vertical interlock from the perspective of information concealing, providing a more in‐depth reference for promoting the sustainable development of enterprises.
Antiracist Structural Intervention at the Emory University Institutional Review Board
Authors: Rollin Francois , Van Doren Vanessa , Alvarez Jessica , Rousselle Rebecca , Bussey‐Jones Jada 
Published: June 2023

ABSTRACTAlthough racial and ethnic categories are social constructs without inherent biologic or genetic meaning, race and ethnicity impact health outcomes through racism. The use of racial categories in biomedical research often misattributes the cause of health inequities to genetic and inherent biological differences rather than to racism. Improving research practices around race and ethnicity is an urgent priority and requires education as well as structural change. We describe an evidence‐based intervention for an institutional review board (IRB). Our IRB now requires all biomedical study protocols to define racial and ethnic classifications they plan to use, to state whether they are describing or explaining differences between groups, and to provide justification for any use of racial or ethnic group variables as covariates. This antiracist IRB intervention is an example of how research institutions can help ensure the scientific validity of studies and avoid the unscientific reification of race and ethnicity as inherently biological or genetic concepts.