bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of stably expressed genes across diverse angiosperms exposes flexibility in underlying promoter architecture
Authors: Yang Eric J.Y. , Maranas Cassandra J. , Nemhauser Jennifer L. 
Published: June 2023

AbstractPromoters regulate both the amplitude and pattern of gene expression—key factors needed for optimization of many synthetic biology applications. Previous work inArabidopsisfound that promoters that contain a TATA-box element tend to be expressed only under specific conditions or in particular tissues, while promoters which lack any known promoter elements, thus designated as Coreless, tend to be expressed more ubiquitously. To test whether this trend represents a conserved promoter design rule, we identified stably expressed genes across multiple angiosperm species using publicly available RNA-seq data. Comparisons between core promoter architectures and gene expression stability revealed differences in core promoter usage in monocots and eudicots. Furthermore, when tracing the evolution of a given promoter across species, we found that core promoter type was not a strong predictor of expression stability. Our analysis suggests that core promoter types are correlative rather than causative in promoter expression patterns and highlights the challenges in finding or building constitutive promoters that will work across diverse plant species.
Classifying innovation in Indonesian public libraries
Authors: Srirahayu Dyah Puspitasari , Harisanty Dessy , Anugrah Esti Putri 
Published: June 2023

Purpose
Public libraries have been making various efforts and innovations to adapt to changes. The purpose of this study is to analyze type of library innovation based on the innovation’s subject.

Design/methodology/approach
The data was collected by identifying the information in regard to the innovation uploaded on the library website. A total of 548 public library websites have been identified, and 1,567 library innovations data have been collected.

Findings
The innovations that have been made and carried out are divided into seven subject categories: inclusion-based innovation, information source innovation, innovation, cooperation, innovation in information services, innovation in library management, innovation with the use of technology. The consequences of innovation in public libraries include increased performance, community empowerment, increased accessibility of information, increased public literacy and external support.

Research limitations/implications
This research only focuses on one type of library, namely, all public libraries in Indonesia. The findings of this study are based on library innovation data taken from the public library website, so that library innovations that are not uploaded to the website are not included in this study.

Originality/value
The impact of the innovations that have been implemented is not only in improving the performance of the library but also the surrounding community. Public libraries must continue to innovate because of the amount that can be obtained for the progress of society, nation and state.
Unpacking the privacy–personalisation paradox in GDPR-2018 regulated environments: consumer vulnerability and the curse of personalisation
Authors: Kawaf Fatema , Montgomery Annaleis , Thuemmler Marius 
Published: June 2023

PurposeThe paper addresses the privacy–personalisation paradox in the post-GDPR-2018 era. As the regulation came in a bid to regulate the collection and use of personal data, its implications remain underexplored. The research question is: How do consumers perceive the matter of personal data collection for the use of highly targeted and personalised ads post-GDPR-2018? The invasion of privacy vs the benefits of highly personalised digital marketing.Design/methodology/approachTo address the research question, this qualitative study conducts semi-structured interviews with 14 individuals, consisting of average users and digital experts.FindingsThis paper reports on increasing consumer vulnerability post-GDPR-2018 due to increased awareness of personal data collection yet incessant lack of control, particularly regarding the repercussions of the digital footprint. The privacy paradox remains an issue except among experts, and personalisation remains necessary, yet critical challenges arise (e.g. filter bubbles and intrusion).Practical implicationsPolicy implications include education, regulating consent platforms and encouraging consensual sharing of personal data.Originality/valueWhile the privacy–personalisation paradox has been widely studied, the impact of GDPR-2018 has rarely been addressed in the literature. GDPR-2018 has seemingly had little impact on instilling a sense of security for consumers; if anything, this paper highlights greater concerns for privacy as users sign away their rights on consent forms to access websites, thus contributing novel insights to this area of research.
A hybrid machine learning approach for early cost estimation of pile foundations
Authors: Deepa G. , Niranjana A.J. , Balu A.S. 
Published: June 2023

Purpose
This study aims at proposing a hybrid model for early cost prediction of a construction project. Early cost prediction for a construction project is the basic approach to procure a project within a predefined budget. However, most of the projects routinely face the impact of cost overruns. Furthermore, conventional and manual cost computing techniques are hectic, time-consuming and error-prone. To deal with such challenges, soft computing techniques such as artificial neural networks (ANNs), fuzzy logic and genetic algorithms are applied in construction management. Each technique has its own constraints not only in terms of efficiency but also in terms of feasibility, practicability, reliability and environmental impacts. However, appropriate combination of the techniques improves the model owing to their inherent nature.

Design/methodology/approach
This paper proposes a hybrid model by combining machine learning (ML) techniques with ANN to accurately predict the cost of pile foundations. The parameters contributing toward the cost of pile foundations were collected from five different projects in India. Out of 180 collected data entries, 176 entries were finally used after data cleaning. About 70% of the final data were used for building the model and the remaining 30% were used for validation.

Findings
The proposed model is capable of predicting the pile foundation costs with an accuracy of 97.42%.

Originality/value
Although various cost estimation techniques are available, appropriate use and combination of various ML techniques aid in improving the prediction accuracy. The proposed model will be a value addition to cost estimation of pile foundations.
Effects of long-term Ashtanga Yoga practice on psychological well-being
Authors: Morris Ben , Jackson James , Roberts III Anthony 
Published: June 2023

Purpose
In recent years, Yoga practice has seen a rapid rise in popularity with many positive consequences, both physical and mental attributed to its practice. Ashtanga Yoga has been less well researched in this area and is the specific focus on this work. The aim of this study is to investigate the possible positive impact of long-term Ashtanga Yoga on psychological well-being.

Design/methodology/approach
In total, 213 long-term Ashtanga Yoga practitioners were asked to complete the positive emotion, engagement, relationships, meaning, accomplishment (PERMA) 23 scale (Butler and Kern, 2016) which measures psychological well-being. The values given by these individuals were then compared against a larger sample of 31,966 representative of the general population.

Findings
Scores were then compared with a PERMA data set representative of the general population (see Butler and Kern, 2016), primarily using a test of difference to compare samples. Secondly, the causal relationship between time spent in practice upon well-being scores.

Research limitations/implications
Findings indicated that those individuals engaged in long-term Ashtanga Yoga practice significantly outperformed the control group on all dimensions of psychological well-being.

Practical implications
This work has demonstrated specific benefits to the practice of Ashtanga Yoga on psychological well-being. Yoga is a form of exercise that is now widely available across the globe, and as such, represents an accessible form of physical practice, which has important psychological benefits.

Originality/value
To the authors’ knowledge, this is the first work investigating differences in psychological well-being profiles using PERMA, as a function of Yoga practice.
Synthesis of modified poly(ester-amide) and alkyd resins based on phenolic and Schiff base compounds to study their biological and insecticide activity for surface coating applications
Authors: G. Elfadel Roma , M. Refat Hala , Abdelwahab H. , S. Salem Salem , Awad Mohamed A. , Abdel Reheim M.A.M. 
Published: June 2023

Purpose
This paper aims to investigate the prepared modified alkyd and poly(ester-amide) (PEA) resins as antimicrobial and insecticide binders for surface coating applications.

Design/methodology/approach
Salicylic diethanolamine and 4-(N, N-dimethylamino) benzylidene glutamic acid were prepared and used as new sources of polyol and dibasic acid for PEA and alkyd resins, then confirmed by: acid value, FT-IR and 1H-NMR. The coating performance of the resins was determined using measurements of physico-mechanical properties. The biological and insecticide activities of the prepared resins were investigated.

Findings
The tests carried out revealed that the modified PEA and alkyd enhanced both phyisco-mechanical and chemical properties in addition to the biological and insecticide activities. The results of this paper illustrate that the introduction of salicylic diethanolamine and 4-(N, N-dimethylamino) benzylidene glutamic acid within the resin structure improved the film performance and enhanced the antimicrobial activity performance of PEA and alkyd resins.

Research limitations/implications
The modified alkyd and PEA organic resins can be used as biocidal binders when incorporated into paint formulations for multiple surface applications, especially those that are exposed to several organisms.

Originality/value
Modified alkyd and PEA resins based on newly synthesized modifiers have a significant potential to be promising in the production and development of antimicrobial and insecticide paints, allowing them to function to restrict the spread of insects and microbial infection.
The Pareto principle: To what extent does it apply to resource acquisition in stable microbial communities and thereby steer their geno−/ecotype compositions and interactions between their members?
Authors: Timmis Kenneth , Verstraete Willy , Regina Viduthalai Rasheedkhan , Hallsworth John E. 
Published: June 2023

AbstractThe Pareto principle, or 20:80 rule, describes resource distribution in stable communities whereby 20% of community members acquire 80% of a key resource. In this Burning Question, we ask to what extent the Pareto principle applies to the acquisition of limiting resources in stable microbial communities; how it may contribute to our understanding of microbial interactions, microbial community exploration of evolutionary space, and microbial community dysbiosis; and whether it can serve as a benchmark of microbial community stability and functional optimality?
Systems biology and metabolic modeling for cultivated meat: A promising approach for cell culture media optimization and cost reduction
Authors: Gomez Romero Sandra , Boyle Nanette 
Published: June 2023

AbstractThe cultivated meat industry, also known as cell‐based meat, cultured meat, lab‐grown meat, or meat alternatives, is a growing field that aims to generate animal tissues ex‐vivo in a cost‐effective manner that achieves price parity with traditional agricultural products. However, cell culture media costs account for 55%–90% of production costs. To address this issue, efforts are aimed at optimizing media composition. Systems biology‐driven approaches have been successfully used to improve the biomass and productivity of multiple bioproduction platforms, like Chinese hamster ovary cells, by accelerating the development of cell line‐specific media and reducing research and development and production costs related to cell media and its optimization. In this review, we summarize systems biology modeling approaches, methods for cell culture media and bioprocess optimization, and metabolic studies done in animals of interest to the cultivated meat industry. More importantly, we identify current gaps in knowledge that prevent the identification of metabolic bottlenecks. These include the lack of genome‐scale metabolic models for some species (pigs and ducks), a lack of accurate biomass composition studies for different growth conditions, and 13C‐metabolic flux analysis (MFA) studies for many of the species of interest for the cultivated meat industry (only shrimp and duck cells have been subjected to 13C‐MFA). We also highlight the importance of characterizing the metabolic requirements of cells at the organism, breed, and cell line‐specific levels, and we outline future steps that this nascent field needs to take to achieve price parity and production efficiency similar to those of other bioproduction platforms.Practical Application: Our article summarizes systems biology techniques for cell culture media design and bioprocess optimization, which may be used to significantly reduce cell‐based meat production costs. We also present the results of experimental studies done on some of the species of interest to the cultivated meat industry and highlight why modeling approaches are required for multiple species, cell‐types, and cell lines.
Race differences in cardiac testing rates for patients with chest pain in a multisite cohort
Authors: Popp Lucas M. , Ashburn Nicklaus P. , Snavely Anna C. , Allen Brandon R. , Christenson Robert H. , Madsen Troy , Mumma Bryn E. , Nowak Richard , Stopyra Jason P. , Wilkerson R. Gentry , Mahler Simon A. 
Published: June 2023

AbstractBackgroundIdentifying and eliminating racial health care disparities is a public health priority. However, data evaluating race differences in emergency department (ED) chest pain care are limited.MethodsWe conducted a secondary analysis of the High‐Sensitivity Cardiac Troponin T to Optimize Chest Pain Risk Stratification (STOP‐CP) cohort, which prospectively enrolled adults with symptoms suggestive of acute coronary syndrome without ST‐elevation from eight EDs in the United States from 2017 to 2018. Race was self‐reported by patients and abstracted from health records. Rates of 30‐day noninvasive testing (NIT), cardiac catheterization, revascularization, and adjudicated cardiac death or myocardial infarction (MI) were determined. Logistic regression was used to evaluate the association between race and 30‐day outcomes with and without adjustment for potential confounders.ResultsAmong 1454 participants, 42.3% (615/1454) were non‐White. At 30 days NIT occurred in 31.4% (457/1454), cardiac catheterization in 13.5% (197/1454), revascularization in 6.0% (87/1454), and cardiac death or MI in 13.1% (190/1454). Among Whites versus non‐Whites, NIT occurred in 33.8% (284/839) versus 28.1% (173/615; odds ratio [OR] 0.76, 95% confidence interval [CI] 0.61–0.96) and catheterization in 15.9% (133/839) versus 10.4% (64/615; OR 0.62, 95% CI 0.45–0.84). After covariates were adjusted for, non‐White race remained associated with decreased 30‐day NIT (adjusted OR [aOR] 0.71, 95% CI 0.56–0.90) and cardiac catheterization (aOR 0.62, 95% CI 0.43–0.88). Revascularization occurred in 6.9% (58/839) of Whites versus 4.7% (29/615) of non‐Whites (OR 0.67, 95% CI 0.42–1.04). Cardiac death or MI at 30 days occurred in 14.2% of Whites (119/839) versus 11.5% (71/615) of non‐Whites (OR 0.79 95% CI 0.57–1.08). After adjustment there was still no association between race and 30‐day revascularization (aOR 0.74, 95% CI 0.45–1.20) or cardiac death or MI (aOR 0.74, 95% CI 0.50–1.09).ConclusionsIn this U.S. cohort, non‐White patients were less likely to receive NIT and cardiac catheterization compared to Whites but had similar rates of revascularization and cardiac death or MI.
The continuous structure of the joint capsule and meniscus in the pig knee
Authors: Natsuyama Yutaro , Zhang Mingshou , Yang Ting , Shimada Kazuyuki , Ren Ke , Kamikawa Yasuko , Tokita Konosuke , Fujiwara Motoi , Chen Juefei , Yi Shuang‐Qin 
Published: June 2023

AbstractThe knee joint capsules composed of a fibrous layer and a synovial layer. The knee meniscus consists of the superficial network, lamellar layer, tie fibre and circumferential bundles. However, the continuous structure of the knee joint capsule and meniscus has not been reported. Fetal and adult pigs were used to investigate the structural relationship between the stifle joint capsule and meniscus based on the gross anatomy and histological findings. In the gross anatomical examination, the joint capsule appeared to have separated attachments to the meniscus, except for the lower aspect of the popliteal hiatus. Histologically, the lower half of the popliteal hiatus was found to have separated attachments, with vessels running between the attachments of the joint capsules. The synovial layer of the joint capsule continued to the superficial network, and the fibrous layer of the joint capsule continued to the lamellar layer and tie fibres. There were two routes of arterial entry into the meniscus: intracapsular and intercapsular. It appeared that the presence of separated attachments of the joint capsule was necessary to allow the intercapsular route. This study clarified for the first time the routes of feeding vessels entering the meniscus and proposed to call this entry point the meniscus hilum. We consider that this detailed anatomical information is important for understanding the continuation between the joint capsule and the meniscus.
Use of a non‐anatomic mini‐fragment fixation system for foot fractures
Authors: Hague Matthew , Pintar Valeria , Nielsen Dominic , Trompeter Alex 
Published: June 2023

AbstractBackgroundPlating techniques for the fixation of foot fractures can utilize pre‐contoured region‐specific plates or non‐anatomic non‐specific mini‐fragment plating systems, however there is limited published data describing complication rates.MethodsThis study reviewed the complication rates and performed a cost analysis of 45 foot fractures that had fixation with the use of mini‐fragment non‐anatomic implants, comparing them to a series from the same centre fixed using anatomic implants and the published literature.ResultsComplication rates seemed equivalent. Cost analysis demonstrated that non‐anatomic implants were more expensive on average.ConclusionsNon‐anatomic mini‐fragment fixation is an appropriate method for use in a variety of foot trauma situations, with comparable complication rates to pre‐contoured implants, although the potential for cost savings has not been realized in this patient cohort.
Observational study on the neonatal outcome during the COVID‐19 pandemic in Germany
Authors: Lau M. , Kraus V. , Schulze A. F. , Rausch T. K. , Krüger M. , Göpel W. 
Published: June 2023

AbstractAimWe aimed to determine stillbirth, preterm birth, perinatal complications, and the developmental outcome of children born preterm during the COVID‐19 pandemic in Germany.MethodsNational data from the perinatal survey of preterm and term infants born in 2017–2020 between 22 March and 31 December were evaluated. Neurodevelopment of preterm infants at 2 years corrected age was tested with the Parent Report of Children's Abilities‐Revised questionnaire and by clinical testing with Bayley scales, either before or during the COVID‐19 pandemic. Statistical significance was calculated using a Pearson's chi‐square‐independence test and a linear regression model.ResultsIn 2020, there was an increase of stillbirths of 0.02% (p = 0.01) and a decrease in preterm births by 0.38% (p < 0.001). No changes were found in a representative subgroup of infants with regard to neurodevelopmental scores (mental developmental index and psychomotor developmental index) or in parent survey data (non‐verbal cognition scale and language development scale).ConclusionIncreasing rates of stillbirths and decreasing preterm births in Germany were observed. Existing networks might stabilise neurodevelopment of preterm infants during the COVID‐19 pandemic.
Platelet count and risk of severe illness in hospitalised children with Influenza‐Like illness
Authors: Elber‐Dorozko Sergei , Kerem Liya , Wolf Dana , Brodie Shlomit , Berkun Yackov , Brooks Rebecca , Breuer Oded 
Published: June 2023

AbstractAimTo examine the clinical significance of thrombocytosis (platelets > 500 × 109/L) in admitted children with an influenza‐like illness.MethodsWe performed a database analysis consisting of patients evaluated at our medical centers with an influenza‐like illness between 2009 and 2013. We included paediatric patients and examined the association between platelet count, respiratory viral infections, and admission outcomes (hospital length of stay and admission to the paediatric intensive care unit) using regression models adjusting for multiple variables.ResultsA total of 5171 children were included in the study cohort (median age 0.8 years; interquartile range, 0.2–1.8; 58% male). Younger age, and not the type of viral infection, was associated with a high platelet count (p < 0.001). Elevated platelet count independently predicted admission outcomes (p ≤ 0.05). The presence of thrombocytosis was associated with an increased risk for a prolonged length of stay (odds ratio = 1.2; 95% Confidence interval = 1.1 to 1.4; p = 0.003) and admission to the paediatric intensive care unit (odds ratio = 1.5; 95% Confidence interval = 1.1 to 2.0; p = 0.002).ConclusionIn children admitted with an influenza‐like illness, a high platelet count is an independent predictor of admission outcomes. Platelet count may be used to improve risk assessment and management decisions in these paediatric patients.
Slow or fast: Implications of myofibre type and associated differences for manifestation of neuromuscular disorders
Authors: Lloyd Erin M. , Pinniger Gavin J. , Murphy Robyn M. , Grounds Miranda D. 
Published: June 2023

AbstractMany neuromuscular disorders can have a differential impact on a specific myofibre type, forming the central premise of this review. The many different skeletal muscles in mammals contain a spectrum of slow‐ to fast‐twitch myofibres with varying levels of protein isoforms that determine their distinctive contractile, metabolic, and other properties. The variations in functional properties across the range of classic ‘slow’ to ‘fast’ myofibres are outlined, combined with exemplars of the predominantly slow‐twitch soleus and fast‐twitch extensor digitorum longus muscles, species comparisons, and techniques used to study these properties. Other intrinsic and extrinsic differences are discussed in the context of slow and fast myofibres. These include inherent susceptibility to damage, myonecrosis, and regeneration, plus extrinsic nerves, extracellular matrix, and vasculature, examined in the context of growth, ageing, metabolic syndrome, and sexual dimorphism. These many differences emphasise the importance of carefully considering the influence of myofibre‐type composition on manifestation of various neuromuscular disorders across the lifespan for both sexes. Equally, understanding the different responses of slow and fast myofibres due to intrinsic and extrinsic factors can provide deep insight into the precise molecular mechanisms that initiate and exacerbate various neuromuscular disorders. This focus on the influence of different myofibre types is of fundamental importance to enhance translation for clinical management and therapies for many skeletal muscle disorders.