bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Characterization, and Properties of Sulfonated CNT‐Doped Poly(aniline‐co‐carbazole)‐PVA Conductive Films
Authors: Lakouraj Moslem M. , Norouzian Rafieh‐sadat , Tavakoli Malihe 
Published: March 2023

AbstractConductive flexible films are successfully synthesized from polyvinyl alcohol matrix and poly(aniline‐co‐carbazole) charge carrier. To improve the mechanical properties of polyvinyl alcohol and promote charge transition in the conductive copolymer, dual purpose sulfonated multiwall carbon nanotube is added. Conductivity is enhanced via sulfonic acid protonic dopant and mechanical property is increased by its hexagonal nanorods. Nanocomposites are prepared by adding 0.025, 0.050, and 0.075 g of carbon nanotube which is added at 1%, 3%, and 5% loads to the polymer matrix. Films are characterized by infrared, UV–vis, X‐ray diffraction, scanning electron microscopy, and thermogravimetric analysis. Conductivity is measured by the four‐probe technique and mechanical property is assessed through tensile tests and dynamic mechanic thermal analysis. A 5 × 10−6 S cm−1 conductivity and 116 MPa tensile strength are recorded for the conductive film with optimum dopant/nanocomposite loads. The electrochemical property and corrosion resistance are studied by cyclic voltammetry and Tafel curves, respectively. The conductive films show an increase in corrosion potential and a decrease in corrosion current referring to a reliable corrosion protection film. The water uptake and contact angle of the films are measured to be 157% and 80.1° respectively to confirm its required hydrophilic property.
BORIS variant SF2(C2/A4) promotes the malignant development of liver cancer by activating epithelial‐mesenchymal transition and hepatic stellate cells
Authors: Wei Ling , Liu Zhongjian , Qin Lu , Xian Longjun , Chen Kefei , Zhou Siqi , Hu Lei , Xiong Yimei , Li Bo , Qin Yang 
Published: March 2023

AbstractThe underlying mechanisms of metastasis and recurrence of liver cancer remain largely unknown. Here, we found that Brother of the Regulator of Imprinted Sites (BORIS) variant SF2(C2/A4) was highly expressed in high metastatic potential hepatocellular carcinoma (HCC) cells and clinical tumor samples, related to the formation of satellite nodules. Its over expression promoted self‐renewal, the expression of tumor stem cell markers, chemoresistance, wound healing rate, invasion and metastasis of HepG2 and Hep3B cells; reinforced epithelial‐mesenchymal transition (EMT), decreased the expression of E‐cadherin and increased N‐cadherin and Vimentin. Subcellular localization experiment showed that BORIS SF2(C2/A4) was localized in nucleus and cytoplasm. Further double luciferase reporter gene experiment confirmed that it bound to TWIST1 gene promoter and significantly increased latter expression. BORIS SF2(C2/A4) knock down induced apoptosis of HCCLM3 and PLC/PRF/5 cells, and increased the protein content of cleaved caspase 3. Additionally, BORIS SF2(C2/A4) over expression increased the expression of fibroblast growth factor 2 (FGF2) in HepG2 and Hep3B cells. FGF2 expressed higher in HCC tumor tissues than in paired peri‐tumor tissues, and its expression was positively correlated with BORIS SF2(C2/A4). Interestingly, high expression of FGF2 is also associated with the formation of satellite nodules. Moreover, using the medium from BORIS SF2(C2/A4) overexpressed cell lines to coculture hepatic stellate cell (HSCs) line LX‐2, the latter could be activated and increased the expression of CD90 and PIGF, which is consistent with the effect of adding bFGF alone. These results indicate that BORIS SF2(C2/A4) plays a role in deterioration of liver cancer by regulating TWIST1 to induce EMT, and by FGF2 to activate HSCs.
Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses
Authors: Carpenter Harry J. , Ghayesh Mergen H. , Zander Anthony C. , Psaltis Peter J. 
Published: March 2023

AbstractIn this paper, we investigate the impact of coronary artery dynamics on the wall shear stress (WSS) vector field topology by comparing fluid–structure interaction (FSI) and computational fluid dynamics (CFD) techniques. As one of the most common causes of death globally, coronary artery disease (CAD) is a significant economic burden; however, novel approaches are still needed to improve our ability to predict its progression. FSI can include the unique dynamical factors present in the coronary vasculature. To investigate the impact of these dynamical factors, we study an idealized artery model with sequential stenosis. The transient simulations made use of the hyperelastic artery and lipid constitutive equations, non‐Newtonian blood viscosity, and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary artery. We compare changes to established metrics of time‐averaged WSS (TAWSS) and the oscillatory shear index (OSI) to changes in the emerging WSS divergence, calculated here in a modified version to handle the deforming mesh of FSI simulations. Results suggest that the motion of the artery can impact downstream patterns in both divergence and OSI. WSS magnitude is also decreased by up to 57% due to motion in some regions. WSS divergence patterns varied most significantly between simulations over the systolic period, the time of the largest displacements. This investigation highlights that coronary dynamics could impact markers of potential CAD progression and warrants further detailed investigations in more diverse geometries and patient cases.
Aridity drives clinal patterns in leaf traits and responsiveness to precipitation in a broadly distributed Australian tree species
Authors: Aspinwall Michael J. , Blackman Chris J. , Maier Chelsea , Tjoelker Mark G. , Rymer Paul D. , Creek Danielle , Chieppa Jeff , Griffin‐Nolan Robert J. , Tissue David T. 
Published: March 2023

AbstractAridity shapes species distributions and plant growth and function worldwide. Yet, plant traits often show complex relationships with aridity, challenging our understanding of aridity as a driver of evolutionary adaptation. We grew nine genotypes of Eucalyptus camaldulensis subsp. camaldulensis sourced from an aridity gradient together in the field for ~650 days under low and high precipitation treatments. Eucalyptus camaldulesis is considered a phreatophyte (deep‐rooted species that utilizes groundwater), so we hypothesized that genotypes from more arid environments would show lower aboveground productivity, higher leaf gas‐exchange rates, and greater tolerance/avoidance of dry surface soils (indicated by lower responsiveness) than genotypes from less arid environments. Aridity predicted genotype responses to precipitation, with more arid genotypes showing lower responsiveness to reduced precipitation and dry surface conditions than less arid genotypes. Under low precipitation, genotype net photosynthesis and stomatal conductance increased with home‐climate aridity. Across treatments, genotype intrinsic water‐use efficiency and osmotic potential declined with increasing aridity while photosynthetic capacity (Rubisco carboxylation and RuBP regeneration) increased with aridity. The observed clinal patterns indicate that E. camaldulensis genotypes from extremely arid environments possess a unique strategy defined by lower responsiveness to dry surface soils, low water‐use efficiency, and high photosynthetic capacity. This strategy could be underpinned by deep rooting and could be adaptive under arid conditions where heat avoidance is critical and water demand is high.
Hydroxyurea treatment for sickle cell anemia during pregnancy and lactation: Current evidence and knowledge gaps
Authors: Dong Min , Ware Russell E. , Dallmann André , Vinks Alexander A. 
Published: March 2023

AbstractSickle cell anemia (SCA) is a life‐threatening genetic condition contributing to high‐risk pregnancies affecting both the mother and fetus. With improved management of children with SCA, this life‐threatening hematological disorder has evolved into a chronic disease of adults, and consequently parenthood has now become a possible and important life goal for many patients. Providing continuous management with healthy red blood cell function and avoiding SCA‐associated complications, such as pain crises, acute chest syndrome, and stroke, are crucial for a healthy pregnancy. Despite its excellent safety profile in non‐pregnant adults and children, and based on theoretical concerns derived from data using animal models and supraphysiological dosing, hydroxyurea is currently contraindicated for pregnant and lactating women with SCA. Clinical experience of hydroxyurea use during pregnancy is increasingly reported, however, and has shown inconsistent results of fetal or infant adverse effects. How the hydroxyurea exposure level may correlate with pregnancy outcomes is still unclear. Accordingly, efforts should be made to systemically evaluate exposure and safety of hydroxyurea treatment during pregnancy and lactation. Novel approaches such as physiologically based pharmacokinetic (PBPK) modeling, coupled with the ex vivo human placental cotyledon perfusion assay, provide opportunities to understand hydroxyurea exposure not only in pregnant women but also in the developing fetus. Combined with animal data, research using these approaches might be able to define safe and effective hydroxyurea dosing regimens for pregnant and lactating women with SCA, when the benefits of continuing hydroxyurea treatment likely outweigh the risks of non‐treatment, by avoiding substantial morbidity and even mortality for both mothers and infants.
“You just want someone to help”: Outcomes that matter to parents when their child is treated for chronic pain
Authors: Joslin Rhiannon , Donovan‐Hall Maggie , Roberts Lisa 
Published: March 2023

AbstractIn children's chronic pain services, healthcare decisions involve a three‐way interaction between the child, their parent or guardian, and the health professional. Parents have unique needs, and it is unknown how they visualize their child's recovery and which outcomes they perceive to be an indication of their child's progress. This qualitative study explored the outcomes parents considered important, when their child was undergoing treatment for chronic pain. A purposive sample of twenty‐one parents of children receiving treatment for chronic musculoskeletal pain, completed a one‐off semi‐structured interview that involved drawing a timeline of their child's treatment. The interview and timeline content were analyzed using thematic analysis. Four themes are evident at different points of the child's treatment course. The “perfect storm” that described their child's pain starting, “fighting in the dark” was a stage when parents focused on finding a service or health professional that could solve their child's pain. The third stage, “drawing a line under it,” changed the outcomes parents considered important, parents changed how they approached their child's pain and worked alongside professionals, focusing on their child's happiness and engagement with life. They watched their child make positive change and moved toward the final theme “free.” The outcomes parents considered important changed over their child's treatment course. The shift described by parents during treatment appeared pivotal to the recovery of young people, demonstrating the importance of the role of parents within chronic pain treatment.
Gas‐phase polymerization of ultra‐high molecular weight polyethylene with decreased entanglement density
Authors: do Rosario Roberta Lopes , Christakopoulos Fotis , Tervoort Theo A. , Brunel Fabrice , McKenna Timothy F. L. 
Published: March 2023

AbstractIt is well known that ultra‐high molecular weight polyethylene (UHMWPE) is a polymer with long chains and very high molecular weight that poses difficulties in terms of processability due to the presence of chain entanglements. In many cases is thus necessary to treat the material in different ways after the polymerization to minimize the amount of entanglements and improve the processability. Based on observations that the use of inert condensing agents (ICA) had a noticeable impact on molecular weight and crystallinity, it was decided to develop a gas‐phase polymerization process with addition of ICA for UHMWPE with a high fraction of disentangled chains. For the optimization of this process, the comparison with slurry is important for the understanding the improvement. Thus, a clear difference between slurry and gas phase is observed in terms of crystallinity and the lamellar thickness of the crystals, molecular weight and entanglements. Characterization techniques are developed to measure the properties of the reactor powder and understand the impact of the alkanes in situ. Using solid‐state drawability, the entanglement degree of the reactor powder is analyzed. From the small‐angle x‐ray scattering and wide‐angle x‐ray scattering techniques, it is possible to find a correlation of entanglements and lamellar thickness. Moreover, crystallization kinetics measurements of the polymer in presence of ICA constitutes a powerful method to explain the phenomena of entanglement and crystal formation.
The impact of elexacaftor/tezacaftor/ivacaftor on body composition in a small cohort of youth with cystic fibrosis
Authors: Granados Andrea , Chan Christine L. , Moheet Amir , Vigers Timothy , Arbeláez Ana María , Larson Ode Katie 
Published: March 2023

AbstractBackgroundThe effects of elexacaftor‐tezacaftor‐ivacaftor (ETI) on body composition in people with CF (pwCF) are unknown.MethodsDual‐energy X‐ray absorptiometry fat‐free mass and fat mass adjusted for height (FMI) as well as oral glucose tolerance test derived measures of insulin secretion and sensitivity were compared before and after ETI initiation in eight pwCF.ResultsPatients median age: 22 years interquartile range (IQR: 16–28), 87.5% male, median time on ETI:11 months. Weight z‐score increased from −0.52 to 0.18 (p = 0.014); FMI increased from 4.12 to 6.29 (p = 0.014). Insulin secretion (C pep iAUC/Gluc iAUC) increased from 8.71 to 14.21 (p = 0.021), insulin resistance (HOMA2 IR) increased from 0.73 to 1.25 (p = 0.014) and insulin sensitivity decreased (Matsuda) 8.88 to 5.58 (p = 0.036).ConclusionsETI resulted in increased weight and fat mass. BMI and muscle mass did not change. Both insulin secretion and insulin resistance increased. Longer‐term metabolic consequences of ETI need further investigation.
Understanding the packaging colour on consumer perception of plant‐based hamburgers: A preliminary study
Authors: da Fonseca Camila , Sá Amanda Gomes Almeida , Ribeiro Gagliardi Talita , dos Santos Alves Maria Jaízia , Ayala Valencia Germán 
Published: March 2023

AbstractPlant‐based hamburgers (PBH) are a recent alternative for consumers who want to reduce meat consumption. The marketing of this type of food has increased in the last few years, being an exciting niche in the food industry. In parallel, food marketing uses packaging to attract consumers, being packaging colour a key to improving consumer perceptions and increasing purchasing intentions. However, no study has explored the ideal packaging colour for PBH. Hence, this research aimed to understand the packaging colour on consumer perception of PBH. A study with 727 volunteers was carried out, and the data were obtained through an online form and analysed using an electronic spreadsheet. Firstly, the diet types and purchasing intention of BPH were analysed. In sequence, it was investigated the perceptions against different colours used in the package of PBH. Neutral (white and black), cool (green, blue and lilac), and warm (red, yellow and magenta) colours were used in the PHB package and data derived from consumers' perceptions were analysed using the word association methodology. Results from volunteers showed that people are interested in buying PBH, including people having a carnivore or flexitarian diet type (89% of volunteers). Important attributes related to PBH were induced in the volunteers using food packaging with green, yellow and white colours. These colours can attract attention and induce emotions related to nature, health, nutritional value and quality in packages of PBH.
What hurt the most? Assessing the influence of pollution and climate change on agricultural sustainability in Asia
Authors: Ramzan Muhammad 
Published: March 2023

AbstractAgriculture faces unprecedented abiotic and biotic stressors due to climate change and environmental contamination. This consequence serves as a severe warning to our society and a challenge to balance sustainable production with rapid population growth. However, prior studies have not explored how pollution and climate change affect agricultural sustainability individually, particularly in Asia. To do so, we examined the analytical linkages between environmental degradation, climate change, governance, and agriculture in Asian countries. To quantify the long‐term estimates, the study employs a fresh econometric approach, such as the generalized method of moments and quantile regression, to test the robustness of all diagnostic checks, notably with the contemplation of outliers performed. The results of panel cointegration tests confirm the long‐term interactions between sustainable agriculture and its determinants. Besides this, it is inferred that governance quality, agricultural land, fertilizers, and stock led to increased agricultural production, whereas carbon emissions and temperature change hurt agricultural performance. Moreover, it is asserted that all predictors have a significant predictive capacity for both measures of agricultural sustainability. These findings are the foundation for a comprehensive set of policies designed to achieve Sustainable Development Agenda 2, 8, and 13 through agricultural sustainability.
Improved Capacitive Energy Storage Nanocomposites at High Temperature Utilizing Ultralow Loading of Bimetallic MOF
Authors: Wang Fan , Cai Jieming , Yang Chenchen , Luo Hang , Li Xiaona , Hou Hongshuai , Zou Guoqiang , Zhang Dou 
Published: March 2023

AbstractIt is urgent to develop high‐temperature dielectrics with high energy density and high energy efficiency for next‐generation capacitor demands. Metal‐organic frameworks (MOFs) have been widely used due to their structural diversity and functionally adaptable properties. Doping of metal nodes in MOFs is an effective strategy to change the band gap and band edge positions of the original MOFs, which helps to improve their ability to bind charges as traps. In this work, the incorporation of ultralow loading (<1.5 wt%) of novel bimetallic MOFs (ZIF 8–67) into the polyetherimide (PEI) polymer matrix is exhibited. With the addition of ZIF 8–67, the breakdown strength and energy storage capacity of ZIF 8–67/PEI nanocomposites are significantly improved, especially at high temperatures (200 °C). For example, the energy densitiy of the 0.5 wt% ZIF 8–67/PEI nanocomposite is up to 2.96 J cm−3, with an efficiency (η) > 90% at 150 °C. At 200 °C, the discharge energy density of 0.25 wt% ZIF 8–67/PEI nanocomposites can still reach 1.84 J cm−3 with a η > 90%, which is nine times higher than that of pure PEI (0.21 J cm−3) under the same conditions, and it is the largest improvement compared with the previous reports.
Code quality improvement using Aquila Optimizer
Authors: Mohamed Amany , Salah Marwa , Eldefrawi Mai 
Published: March 2023

AbstractThe software industry always requires high‐quality software. Code quality has been improved via refactoring and re‐refactoring and removing code smells. Refactoring is a technique to improve existing code by modifying inner structure, while code smells are indication that might have a wrong in code that causes a negative impact on the code quality. According to previous studies, the accuracy of code smell detection was not stable and could be improved by advanced algorithms. Additionally, the impact of refactoring on each of the quality attributes is unclear. This research proposes the use of Aquila Optimizer to detect code smells in addition to investigate the refactoring and re‐refactoring impact through ISO 9126 model. The experiment is conducted on five open‐sources Java projects to detect nine code smell types and measure the values of the ISO 9126 before and after the refactoring and re‐refactoring techniques to show the impact on code quality. The results showed that the average of detection accuracy is 95.18% and 95.68% for precision and recall, respectively. Moreover, the results in large projects are better than in the medium projects. The findings also show improvement in the values of the ISO 9126 model after applying refactoring and re‐refactoring.
A new multiresidue thin layer chromatography–ultraviolet detection method for the rapid determination of six herbicides residue applied as ready mix formulation for rice
Authors: Sondhia Shobha 
Published: March 2023

AbstractThe purpose of this study was to develop a new multiresidue thin‐layer chromatography analysis method for the simultaneous analysis of herbicides in soil and plant samples. A new liquid‐liquid extraction method was also developed for the extraction and identification of herbicides from the soil, rice grain, and straw samples. The thin layer chromatography‐ultra violet technique with silica gel 60 F254 thin layer chromatography plates, using a solvent system consisting of ethyl acetate, hexane, benzene, and methanol was found to be most effective in simultaneous separation and identification of all herbicides with retention factor in the range of 0.21–0.91. The impurities and matrix effects from soil, water, grain, and straw were minimal and did not interfere with the identification of any targeted herbicide. The method developed is found suitable to detect residues of herbicides in the soil, rice grains, and straw samples with a limit of determination of 0.1–0.01 mg/kg. The validation parameters of the developed method were satisfactory and therefore can be successfully used for the simultaneous determination of the herbicides in the soil, water, and plant samples. This method can also be used to determine these herbicides in other environmental samples as well as in Forensic analysis of biological/non‐biological samples.
Handling Missing Data in Principal Component Analysis Using Multiple Imputation
Authors: van Ginkel Joost R. 
Published: March 2023

AbstractPrincipal component analysis (PCA) is a widely used tool for establishing the dimensional structure in questionnaire data. Whenever questionnaire data are incomplete, the missing data need to be treated prior to carrying out a PCA. Several methods exist for handling missing data prior to carrying out a PCA. The current chapter first discusses the most recent developments regarding the treatment of missing data in PCA. Next, of these methods, the method that is most promising both from a theoretical and practical point of view will be discussed in more detail, namely, multiple imputation. Finally, some extensions of multiple imputation to other PCA-related techniques or to statistics within PCA beyond the basics are discussed, and some general recommendations regarding the use of PCA on multiply imputed datasets in different statistical software packages will be given.