bluuebunny/crossref_metadata_2025_split huggingface dataset:
ON THE ISSUE OF TRANSPORTATION OF LIQUEFIED CARBON DIOXIDE
Authors: Vanchugov Ivan M. , Rezanov Konstantin S. , Shestakov Roman A. 
Published: August 2023

Link for citation: Vanchugov I.M., Rezanov K.S., Shestakov R.A. On the issue of transportation of liquefied carbon dioxide. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 8, рр. 190-209. In Rus.
The relevance of the study is caused by the need to capture and utilize one of the main types of greenhouse gases – carbon dioxide (CO2). This need is primarily related to the ever-increasing CO2 emissions, three quarters of which are accounted for by the combustion of various fuels. The main aim is to analyze and systematize international methods for calculating the pipeline transport of liquefied carbon dioxide (LCO2) to determine differences in numerical results, including factors taken into account and not taken into account in the methods under consideration, as well as to analyze water transport type as an alternative to pipeline transport. Objects: liquefied carbon dioxide, a pipeline for transporting LCO2. Methods: numerical modeling of LCO2 pipeline transport according to international methods to estimate the required diameter capable of providing a given pumping flow rate, analysis of the results obtained. Results. The authors have carried out a review of existing methods for calculating LCO2 pipelines, carried out numerical modeling and analysis of the results were, during which it was revealed that most models ignore the influence of impurities, which, however, affect the technological parameters of operation and modeling of LCO2 pipelines, which will lead to inaccuracies in their design and operation. In addition, it was found that the fluid velocity in the pipeline is calculated according to the parameters in the initial section, which corresponds to its minimum value in the pipeline, and is assumed to be equal to it throughout the pipeline without taking into account the expansion of LCO2 from changes in temperature and pressure along its length and, consequently, without taking into account additional pressure losses and changes in other technological parameters that they can directly affect the operational safety and economic efficiency of the designed or operated LCO2 pipeline. It should also be noted that the diameter determination equations depending on the length of the pipeline are not suitable for estimating the optimal diameter of the pipeline. As for alternatives to pipeline transport, first of all, it is worth noting the possibility of transportation by tankers over long distances or the possibility of using LCO2 to increase the flow rate of deposits on the shelf and in hard-to-reach places of the coastal zone.
REHABILITATION OF MAN-MADE FORMATION OF ABANDONED COPPER PYRITE DEPOSITS ON THE EXAMPLE OF LEVIKHINSKY MINE (MIDDLE URALS)
Authors: Rybnikova Liudmila S. , Rybnikov Petr A. , Navolokina Vera Y. 
Published: August 2023

Link for citation: Rybnikova L.S., Rybnikov P.A., Navolokina V.Y. Rehabilitation of man-made formation of abandoned copper pyrite deposits on the example of Levikhinsky mine (Middle Urals). Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering, 2023, vol. 334, no. 8, рр. 137-150. In Rus.
The relevance of the research is related to the need to rehabilitate of abandoned copper pyrite deposits affected by acid mine waters and justify measures to clean up the existing clarification pond. The main aim is to study the sludge composition and justify the measures to reduce the environmental load on the hydrosphere. Objects: clarification pond and neutralization sludge of the Levikhinsky copper pyrite mine acid mine waters. Methods. Laboratory studies of water and bottom sediments were carried out using atomic emission and mass spectral analysis; methods of flame emission spectrometry, flame atomic absorption, photometric method with Nessler's reagent, titrimetric, mercumetric and potentiometric methods; mass spectrometry with ionization in inductively coupled plasma and gravimetric method. Results. Sludge samples are dominated by sulfates (gypsum and bassanite), iron oxides and hydroxides (goethite), carbonates (calcite), clay minerals (mainly hydromica) and chlorine-containing salts (carnallite). The chemical composition of the sludge is dominated by oxides of iron, sulfur and calcium. The analysis of water and acid extracts showed that up to 24 elements belonging to hazard classes 2, 3 and 4 can be leached from the sludge in concentrations exceeding the maximum allowable values for fishery water bodies. Several options for the use of sludge from the clarification pond were analyzed: reclamation of waste rock dumps and substandard ores; backfilling of mined-out area of quarries; production of building materials; extraction of components; storage of sludge in geotubes (Geotube). The most rational is the disposal of sludge as the production of building materials on the basis of a public-private partnership, the implementation of which will allow the state and the private sector to derive mutual benefit.
Successful use of HTF as a basal fertilization medium during SEcuRe mouse in vitro fertilization
Authors: Wigger Magdalena , Schneider Marco , Feldmann Anni , Assenmacher Sonja , Zevnik Branko , Tröder Simon E. 
Published: August 2023

Abstract
Objective: The ever-increasing number of genetically engineered mouse models highlights the need for efficient archiving and distribution of these lines. Sperm cryopreservation has become the preferred technique for the majority of these models due to its low requirement of costs, time, and experimental animals. Yet, current in vitro fertilization (IVF) protocols either exhibit decreased fertilization efficiency for the most popular C57BL/6 strain, as recently demonstrated by us, or require costly and difficult-to-prepare media, respectively. As a result, we previously developed SEcuRe, a modified IVF protocol with low costs and high fertilization efficiency. The popular basal fertilization medium, Cook’s® proprietary “Research Vitro Fert” (RVF), used in this protocol has recently been discontinued. As a result, the application of the SEcuRe approach and other IVF protocols employing this medium has been severely limited.
Results: Here we show that human tubal fluid (HTF), a popular and widely available medium with a known composition, can be used as a basal fertilization medium instead of RVF. Comparison of RVF and HTF during 58 independent SEcuRe IVFs with cryopreserved C57BL/6 sperm revealed equal fertilization and live rates. In addition, we demonstrate that HTF has a substantially extended shelf-life by utilizing commercial HTF that was six months past its expiration date, yet did not affect fertilization during IVF or subsequent embryo development. This finding not only increases the economic value of our modified method, but also validates it once more. Our results demonstrate that common, shelf-life extended HTF can be used in SEcuRe IVF in place of now-discontinued RVF medium and ensure the applicability of the method, which we since termed SEcuRe 2.0. Our modified SEcuRe 2.0 strategy will assist researchers to efficiently archive and distribute genetically engineered mouse models in a cost-effective, easily adaptable, and 3R-compliant manner with minimal animal use.
Microstructure and hydrogen embrittlement of Q690 bainitic steel welded using electron beam
Authors: yang Pengcong , Fu Kuijun , Wu Yumin , Wang Jiaji , Hu Fengya , Song Yulai 
Published: August 2023

Abstract

In this study, Q690 bainitic steel was welded through vacuum electron beam welding under currents of 350 and 500 mA, resulting in samples with different microstructures and fusion and heat-affected zones. Furthermore, H2S immersion tests were performed to determine the susceptibility of the welded microstructure to hydrogen embrittlement. The results indicated fracture occurrence in the coarse-grain heat-affected zone (CGHAZ) and the fusion zone of the samples welded under currents of 350 and 500 mA, respectively. Under the 350-mA welding current, fracture occurred in the CGHAZ because of the high dislocation density in the bainitic ferrite plates and the low amount of retained austenite in the CGHAZ. Under the 500-mA current, hydrogen embrittlement and fracture occurred because of the high welding-induced heat input that led to coarse precipitation and micro-void coalescence in the upper bainite of the fusion zone.
The necessity of gait evaluation on the 7th day after tap tests for the idiopathic normal pressure hydrocephalus patients.
Authors: Oike Ryo , Inoue Yasuaki , Ota Yoshiaki , Sorimachi Takatoshi 
Published: August 2023

Abstract
Background
A tap test is established as an evaluation method to indicate shunt surgery for hydrocephalus, especially idiopathic normal pressure hydrocephalus (iNPH). The timing of gait assessment after the test is still controversial, while some studies reported the effectiveness of the gait evaluation up to 2nd day after tap tests. Our study explored whether the gait evaluation on the 7th day after a tap test is necessary.
Methods
We retrospectively evaluated 129 consecutive cases with possible iNPH who performed gait assessment on all 1st, 3rd, and 7th days after tap tests between May 2020 and February 2022. We reviewed the following items of the patients: age, sex, modified Rankin scale, iNPH grading scale, Mini-Mental State Evaluation (MMSE), and neurological imaging. The number of probable iNPH patients who improved their gait each day after the test was analyzed. We also assessed the number of definite iNPH patients and revealed the background characteristics of the patients who showed gait improvement on the 7th day after the tests.
Results
Of the 129 patients who met our inclusion criteria, 57 were judged as probable iNPH on the 1st day, 28 were new on the 3rd, and 23 were new on the 7th. The number of probable iNPH patients up to the 7th day after testswas significantly more extensive than that of those up to the 3rd (108 [83.7%] vs. 85 [65.9%]; 95% confidence interval [CI], p < 0.0001). The number of definite iNPH patients was also significantly more prominent when the evaluation after the tests was performed on all of the 1st, the 3rd, and the 7th days than just on the 1st (72 vs. 42; 95% CI, p = 0.00016) or both of the 1st and the 3rd (72 vs. 61; 95% CI, p = 0.00074). No statistically significant difference existed in the patients’ backgrounds except for the pre-tap test MMSE.
Conclusion
Gait evaluation on the 7th day after tap tests, in addition to the first few days, may reduce the number of iNPH patients who miss the opportunity of getting beneficial treatment.
The regular study of the influence of rotational speed and height on the mixing performance ofArc-Blade stirrer at different blade diameters
Authors: Lingyan Ma , Li Yibin , Zhou Huan , Tie Xingyu , Zhao Rensheng , Zhou Wenhan 
Published: August 2023

Abstract
By comparing and analysing the mixing time, the mixing energy per unit volume, power, the solid phase particle distribution and turbulent kinetic energy variation at different blade diameters of Arc-Blade stirrer at different heights and rotational speeds. The results show that as the blade diameter increases, the influence of rotational speed on mixing time and solid phase particle motion decreases and then increases, and the influence on power and turbulent kinetic energy increases, with no significant influence on the mixing energy per volume. As the blade diameter increases, the degree of influence of the height on mixing time and solid phase particle motion decreases, then increases and then decreases, with no significant influence on power and turbulent kinetic energy.When the height is lower than H/3, the blade diameter increases and the degree of influence of height on the mixing energy per unit volume first increases and then decreases. Conversely, the degree of influence of height on the mixing energy per unit volume increases.The research can explain to a certain extent the degree of influence of blade diameter on the flow field when the design parameters change, and can provide theoretical guidance for mechanical mixing, which has certain engineering application significance.
Polypharmacy in the elderly cancer patients receiving systemic therapy is associated with more unpredicted hospitalizations.
Authors: Bandidwattanawong Chanyoot , Rattanaserikulchai Puttimon , Jetsadavanit Nontakorn 
Published: August 2023

Abstract
Objectives: Cancer is the disease of the ageing. Most of the elderly cancer patients have pre-existing illnesses requiring complexity of medical care. Excessive medications would lead not only futility, but also result in adverse outcomes especially if such over-prescription is not appropriate. This study was intended to determine the prevalence of polypharmacy (PP) and potentially-inappropriate medications (PIMs) among elderly cancer patients eligible for active cancer care and their associations with hospitalization and mortality.
Materials and methods: This was a prospective cohort study conducted among the elderly non-hematologic cancer patients (> 65 years old) whom a medical oncologist had decided suitable for systemic cancer therapy. Demographic data including age, sex, primary site of cancer, cancer stage at diagnosis, Charlson Comorbidity Index (CCI), numbers and kinds of medications used both prior to and during cancer treatment were recorded. Hospitalizations not related to systemic cancer therapy administration and mortality were prospectively monitored. All of the patients had to be followed at least one year after cancer diagnosis.
Results: There were 180 eligible participants. Median age in years (IQR) was 68 (65-73). One hundred patients (55.56%) were male and 80 patients (44.44%) were female. Breast (35, 19.44%), pulmonary (31, 17.22%) and colorectal (18, 10%) cancers were the most common diagnoses. Eighty-six patients (47.78%) had metastatic disease at cancer diagnosis. One hundred twenty-two patients (67.78%) had PP (> 5 medications a day) and thirty-six patients (20%) had hyper-PP (> 10 medications a day). One hundred twenty five of the whole cohort (69.4%) had PIMs. Patients with more serious CCI scores were associated with PP and hyper-PP. Factors correlated with 1-year mortality were more advanced age group (70 years old or more) (OR 2.244; 95% C.I.,1.14-4.415; p = 0.019), primary pulmonary cancer (OR 2.892; 95% C.I.,1.448-5.775; p = 0.003), metastatic disease at cancer diagnosis (OR 4.459; 95% C.I.,1.903-10.97; p = 0.001), and repeated unexpected hospitalizations (OR 3.093; 95% C.I.,1.597-5.989; p = 0.001). The corrected PP (excluding opioids, laxatives and anti-emetics) did not associate with 1-year survival. While male gender (OR 2.349; 95% C.I., 1.173-4.706); p = 0.016), metastatic stage at cancer diagnosis 2.742; 95% C.I., 1.328-5.663; p = 0.006) and corrected PP (OR 1.898; 95% C.I. 1.012-3.557; p = 0.046) were the significant predictive factors of repeated unexpected hospitalizations.
Conclusion: Among elderly cancer patients suitable for systemic cancer therapy, around two thirds of patients had PP and PIMs. Higher CCI score was the only significant predictor of PP; while primary pulmonary cancer was the sole independent factor predicting PIMs. PP was associated with repeated unexpected hospitalization, albeit not the survival.
MPZL2—A common autosomal recessive deafness gene related to moderate sensorineural hearing loss in the Chinese population
Authors: Zhang Lang , Yang Jin-Yuan , Wang Qiu-Quan , Gao Xue , Wang Guo-Jian , Han Ming-Yu , Kang Dong-Yang , Han Dong-Yi , Huang Sha-Sha , Yuan Yong-Yi 
Published: August 2023

Abstract
Background: Mutations in MPZL2, the characteristic genetic etiology of autosomal recessive deafness loci 111 (DFNB111), cause non-syndromic and moderate sensorineural hearing loss.
Methods: In this study, we analyzed the phenotype and genotype of 8 pedigrees consisting of 10 deaf patients with bi-allelic pathogenic or likely pathogenic variants in MPZL2. These patients were identified from a 3272 Chinese patient cohort who underwent genetic testing.
Results: Apart from symmetrical and moderate sensorineural hearing loss, the MPZL2-related phenotype was characterized by progressive hearing loss with variation in the onset age (congenital defect to onset at the young adult stage). We determined that in the Chinese population, the genetic load of MPZL2 defects was 0.24% (8/3272) in patients diagnosed with hearing loss and 13.11% (8/61) in patients diagnosed with hereditary moderate sensorineural hearing loss caused by STRC, OTOA, OTOG, OTOGL, TECTA, and MPZL2 variants. Three known MPZL2 variants (c.220C>T (p.Gln74*), c.68delC (p.Pro23Leufs*2), c.463delG (p.Ala155Leufs*10)) and a novel start loss variant (c.3G>T (p.Met1?)) were identified. A 3D model of wild type and mutants of myelin protein zero-like 2 (MPZL2) was constructed and spatial structure analysis revealed that mutational susceptibility in the signal peptide domain might be explained by the instability of the loop structure. By allele frequency analysis, MPZL2 c.220C>T was identified as the hotspot variant in the Chinese population and even in East Asia compared with c.72delA (p.Ile24Metfs*22) in European and West Asia.
Conclusions: We concluded that apart from moderate HL, progressive HL is another character of MPZL2-related HL, although no specified variant was verified for the progression of HL, and the penetrance and expressivity cannot be determined yet. A novo MPZL2 variant at the start codon was identified which enriched the variant spectrum of MPZL2. The hotspot variants of MPZL2 vary in different ethnicities. This study provides valuable data for the diagnosis, prognosis evaluation and genetic counseling of patients with moderate sensorineural hearing loss related to MPZL2.
The Association between Cognitive Impairment and Body Composition among the Elderly: Birjand Longitudinal Aging Study
Authors: Kashal Fatemeh Ramezani , Nouredini Golnoush , Hezaveh Zohreh Sajadi , Fakhrzadeh Hossein , Moodi Mitra , Khorashadizadeh Masoumeh , Khodabakhshi Huriye , Arzaghi Seyed Masoud , Ebrahimpour Mahboubeh , Payab Moloud , Ejtahed Hanieh-Sadat , Sharifi Farshad 
Published: August 2023

Abstract
Background: The population of older adults has been steadily increasing around the world. We aimed to assess the possible relationship between cognitive decline and anthropometric indices in older adults, using data from the Birjand longitudinal aging study (BLAS).
Methods: In this cross-sectional research, the association between cognitive impairment (Six Item Cognitive Impairment Test (6-CIT)) and (Mini-Mental State Examination (MMSE)) and body composition indices including waist circumference (WC), body mass index (BMI), waist to height ratio (WHtR), waist to hip ratio (WHR), body roundness index (BRI) and a body shape index (ABSI) were assessed among 1353 elderly ≥ 60 years old, participating in the BLAS cohort study (September 2018 to April 2019). Ordinal and binary logistic regression were used for analysis.
Results: According to the MMSE test, 58.3% of participants had cognitive impairment while this frequency was 64.2% based on 6-CIT test. A significant reverse association was observed between cognitive decline according to 6-CIT test and BMI, WHR and, WC (P<0.05). Cognitive impairment according to MMSE was inversely associated with WC and directly associated with WHtR and ABSI in the crude model, which disappeared after adjustment for confounders. BRI was not significantly related to any of the cognitive tests. According to BMI and WC, overweight and obesity could reduce the risk of cognitive impairment.
Conclusions: Overall, the result of this study showed that the risk of cognitive decline reduced among the elderly as BMI, WC, and WHR increased.
An Investigation of the On-board Microwave Radiometer of Satellite Altimetry for Studying the Atmosphere Variability
Authors: Abdullah Noor , Wijaya Dudy D. , Meilano Irwan , Kuntjoro Wedyanto , Tanuwijaya Zamzam , Abdillah Muhammad , Nurzaman Fathin 
Published: August 2023

Abstract

Since its first launching, the ability of satellite Altimetry in providing reliable and accurate ocean geophysical information of the sea surface height (SSH), significant wave height (SWH), and wind speed has been proven by numerous research, as it was designed for observing the ocean dynamics through nadir range measurement between satellite and the sea surface. However, to achieve high level accuracy, environmental and geophysical effects on the range measurement must be accurately determined and corrected, in particularly the effects from the atmospheric water vapor which can divert altimeter range up to 3–45 cm. Thus, satellite Altimetry is originally equipped by the on-board microwave radiometer to measure the water vapour content for correcting the range measurement. To our knowledge, no one has attempted to apply the on-board radiometer for atmospheric studies. In this present work, we attempt to optimize the on-board radiometer data for studying the atmosphere variability due to the El Niño–Southern Oscillation (ENSO) phenomena. We convert the on-board water vapor data into the precipitable water vapour (PWV), and we then investigate whether the derived PWV can capture the variability of ocean-atmosphere phenomena due to ENSO as accurate as the traditional Altimetry-derived sea level anomaly (SLA). Based on our analysis using the empirical orthogonal function (EOF), the results show convincing argument that Altimetry-derived PWV are reliable in examining the atmospheric fluctuation as the correlation of its primary principal component time series (PC1) with Oceanic Nino Index is higher (0.87) than SLA (0.80). The correlations between two dominant principal components (PC1 and PC2) of PWV and SLA are high, which are approximately 0.93 and − 0.67 for PC1 and PC2, respectively. These results may reinforce the confidence in the ability of satellite Altimetry for ocean-atmospheric studies.