bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of donor sex on hepatocellular carcinoma recurrence in liver transplantation after brain death
Authors: Nakamura Tsukasa , Sasaki Kazunari , Kojima Lisa , Teo Richard , Inaba Yosuke , Yamamoto Takayuki , Kimura Shoko , Dageforde Leigh Anne , Yeh Heidi , Elias Nahel , Bozorgzadeh Adel , Kawai Tatsuo , Markmann James F. 
Published: April 2023

AbstractBackgroundHepatocellular carcinoma (HCC) is predominantly seen in males but has a better prognosis in females. No prior studies have investigated HCC recurrence based on sex combination following liver transplant donated after brain death (DBDLT). This study sought to elucidate the effects of donor and recipient sex on HCC recurrence rates.Methods9232 adult recipients from the United Network for Organ Sharing (UNOS) database who underwent DBDLT for HCC from 2012 to 2018 were included. Donor‐recipient pairs were divided into (1) female donor/female recipient (F‐F) (n = 1089); (2) male donor/female recipient (M‐F) (n = 975); (3) female donor/male recipient (F‐M) (n = 2691); (4) male donor/male recipient (M‐M) (n = 4477). The primary prognostic outcome was HCC recurrence. A multivariable competing risk regression analysis was used to assess prognostic influences.ResultsThe median recipient age and model for end‐stage liver disease (MELD) scores were similar among the four groups. Livers of male recipients demonstrated greater in size and number of HCC (both p‐values were <.0001). There was also a higher rate of vascular invasion in male recipients compared to female (p < .0001). Competing risk analyses showed that the cumulative HCC recurrence rate was significantly lower in the M‐F group (p = .013). After adjusting for tumor characteristics, liver grafts from male donors were associated with a lower HCC recurrence rate in female recipients (HR: .62 95%CI: .42‐.93) (p = .021).ConclusionIn DBDLT, male donor to female recipient pairing exhibited lower HCC recurrence rates.SummaryLowest rates of HCC recurrence were confirmed among the female recipients of male donor grafts group in the deceased donor LT cohort. A competing risk multivariable regression analysis demonstrated that male donor sex was significantly associated with low HCC recurrence in female but not male recipients.
Continuous versus intermittent infusion of human antithrombin III concentrate in the immediate postoperative period after liver transplantation
Authors: Kim Bo Rim , Lim Leerang , Choi YoungRok , Yi Nam‐Joon , Lee Kwang‐Woong , Suh Kyung‐Suk , Yu Kyung‐Sang , Sohn Jin Young , Jeong Raewon , Oh Jaeseong , Ryu Ho Geol 
Published: April 2023

AbstractAntithrombin‐III (AT‐III) concentrates have been used in the immediate postoperative period after liver transplantation to prevent critical thrombosis. We aimed to investigate a more appropriate method for AT‐III concentrate administration to maintain plasma AT‐III activity level within the target range. In this randomized controlled trial, 130 adult patients undergoing living‐donor liver transplantation were randomized to either the intermittent group or continuous group. In the intermittent group, 500 international units (IU) of AT‐III concentrate were administered after liver transplantation and repeated every 6 h for 72 h. In the continuous group, 3000 IU of AT‐III were continuously infused for 71 h after a loading dose of 2000 IU over 1 h. Plasma AT‐III activity level was measured at 12, 24, 48, 72, and 84 h from the first AT‐III administration. The primary outcome was the target (80%–120%) attainment rate at 72 h. Target attainment rates at other timepoints and associated complications were collected as secondary outcomes. A total of 107 patients were included in the analysis. The target attainment rates at 72 h post‐dose were 30% and 62% in the intermittent group and continuous group, respectively (p = 0.003). Compared to the intermittent group, patients in the continuous group reached the target level more rapidly (12 vs. 24 h, median time, p < 0.001) and were more likely to remain in the target range until 84 h. For maintaining the target plasma AT‐III activity level after living‐donor liver transplantation, continuous infusion of AT‐III seemed to be more appropriate compared to the conventional intermittent infusion regimen.
When patients have better insurance coverage in China: Provider incentives, costs, and quality of care
Authors: Luan Mengna , Shi Wenjing , Tao Zhigang , Yuan Hongjie 
Published: April 2023

AbstractThis paper uses a patient discharge dataset from China to study whether and how medical expenses increase for those patients who have better insurance coverage. It uncovers consistent increases in total medical expenses and across each of the three broad categories of expenses (prescription drug expenses, diagnostic test expenses, and other service expenses), no improvement in the quality of care delivered. These increases in expenses can be attributed to patients, physicians, or both. The study provides evidence that physicians' financial incentives play an important role in inducing the increase in medical expenses and that physicians' workload level affects the role of their financial incentives.
Perceptions of emergency department physicians regarding the management of traumatic dental injuries
Authors: Steeves Erin , Doyle Tracy , Mello Isabel 
Published: April 2023

AbstractBackground/AimThe purpose of this study was to investigate the self‐reported confidence level and education of Atlantic Canada emergency department physicians in the management of traumatic dental injuries and to assess the need for further education surrounding the management of dental trauma.Material and MethodsAn 18‐item survey was developed and distributed electronically to physicians by their respective provincial medical associations.ResultsTraumatic dental injuries were reported in the emergency department on a weekly basis (78%). Most respondents reported that they were somewhat confident (51%) or very confident (7%) in managing traumatic dental injuries. Physicians' years in practice correlated positively with self‐reported confidence levels in managing dental trauma. Urban and rural emergency department physicians reported similar levels of access to general dentists (38% and 30%, respectively); however, urban emergency department physicians reported greater access to pediatric dental specialists (43%) and oral and maxillofacial surgeons (81%) than rural practicing colleagues (4% and 30%, respectively). Most emergency department physicians (85%) agreed that it was important to receive training on the management of traumatic dental injuries and reported that education on managing traumatic dental injuries during residency (37%) and access to a dental trauma decision‐making pathway (30%) would be of most value.ConclusionsThis study highlights the role of emergency department physicians as first responders and demonstrates opportunities for improvement in the initial management of traumatic dental injuries. These implications can be achieved through the incorporation of further training in emergency medicine residency programs and through the implementation of decision‐making pathways in emergency departments.
Promoting Indigenous‐led restoration: The Seed and Nursery Industry Forum for Aboriginal Organisations, Northam, Western Australia, September 2022
Authors: Miller‐Sabbioni Christian , van Leeuwen Stephen , Knight Andrew T. , Dixon Kingsley , Turner Shane , Just Michael , Pedrini Simone 
Published: April 2023

SummaryBilya Bilya Koort Boodja Centre for Nyoongar Culture and Environmental Knowledge in Northam, Western Australia, was the location for this event where legislators, practitioners, academics, Nyoongar Elders, and key representatives for Traditional Steward groups gathered to discuss the current issues and future trajectory of the emerging Indigenous nursery sector, specifically the activities of native seed and seedling supply chain. These activities are key components of the emerging Indigenous‐led restoration economy and indispensable for biodiverse restoration of degraded ecosystems at the landscape scale. Key outcomes included: improved awareness in participants about activities being undertaken across the restoration economy sector; the acknowledgement of a disjunction between academia and business practice, and the realisation that bridging the gap between knowledge and action is becoming increasingly urgent.
Chronic inflammatory neuropathies and their impact on activities and participation
Authors: Wonink Henderyke A. , Kruithof Willeke J. , Goedee H. Stephan , Beelen Anita 
Published: April 2023

AbstractBackgroundChronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are inflammatory neuropathies that can lead to considerable limitations in daily activities and in social participation. However, systematic evaluation of these self‐reported limitations is lacking in the currently available studies. Understanding the impact of these diagnoses on patients' life is important to optimize management strategies.AimTo systematically assess the self‐reported limitations in activities and participation and determine associated factors.MethodsA survey study was conducted in 2021 in a cohort of patients with CIDP (n = 257) and MMN (n = 148) from a university hospital. The survey included the Rasch‐built Overall Disability Scale and the Utrecht Scale for Evaluation of Rehabilitation‐Participation, questions addressing personal and disease‐related factors and treatment. Multivariate linear regression analysis was used to determine associations with disease‐related and personal factors.ResultsA total of 147 CIDP and 103 MMN patients responded. Limitations in activities were reported by 70.7% CIDP and 52.2% MMN patients with moderate to severe limitations in 22.4% and 5.9% patients, respectively. Participation restrictions were reported by 50% of CIDP and 40% of MMN patients, nevertheless satisfaction with participation was high. Fatigue, pain and resilience were independently associated with limitations in activities and satisfaction with participation in CIDP patients.ConclusionsActivity limitations and restrictions in participation are common in CIDP patients and to a lesser extent in MMN patients. Fatigue, pain and resilience independently contributed to perceived limitations in CIDP patients. Referral to a rehabilitation physician is warranted to address these limitations appropriately.
Review and standard operating procedures for collection of biospecimens and analysis of biomarkers innew onsetrefractory status epilepticus
Authors: Hanin Aurélie , Cespedes Jorge , Pulluru Yashwanth , Gopaul Margaret , Aronica Eleonora , Decampo Danielle , Helbig Ingo , Howe Charles L. , Huttner Anita , Koh Sookyong , Navarro Vincent , Taraschenko Olga , Vezzani Annamaria , Wilson Michael R. , Xian Julie , Gaspard Nicolas , Hirsch Lawrence J. 
Published: April 2023

AbstractNew onset refractory status epilepticus (NORSE), including its subtype with a preceding febrile illness known as febrile infection‐related epilepsy syndrome (FIRES), is one of the most severe forms of status epilepticus. The exact causes of NORSE are currently unknown, and there is so far no disease‐specific therapy. Identifying the underlying pathophysiology and discovering specific biomarkers, whether immunologic, infectious, genetic, or other, may help physicians in the management of patients with NORSE. A broad spectrum of biomarkers has been proposed for status epilepticus patients, some of which were evaluated for patients with NORSE. Nonetheless, none has been validated, due to significant variabilities in study cohorts, collected biospecimens, applied analytical methods, and defined outcome endpoints, and to small sample sizes. The NORSE Institute established an open NORSE/FIRES biorepository for health‐related data and biological samples allowing the collection of biospecimens worldwide, promoting multicenter research and sharing of data and specimens. Here, we suggest standard operating procedures for biospecimen collection and biobanking in this rare condition. We also propose criteria for the appropriate use of previously collected biospecimens. We predict that the widespread use of standardized procedures will reduce heterogeneity, facilitate the future identification of validated biomarkers for NORSE, and provide a better understanding of the pathophysiology and best clinical management for these patients.
Antecedents of intention to use chatbots in service encounters: A meta‐analytic review
Authors: Gopinath Krishnan , Kasilingam Dharun 
Published: April 2023

AbstractThe trend of using artificial intelligence based chatbots for service encounters has seen a significant spike in recent times. Many studies have attempted to explain the adoption of the technology for various service applications; this study synthesizes the literature through a meta‐analysis, for which data from 70 independent studies, with a combined sample size of 20,026 was considered, to understand the influencers of the attitude and intention to use chatbots for service encounters. In addition, this study also sought to understand the moderating role of the culture, the technological characteristics captured through the variables transactional/non‐transactional, and informative/entertaining of the hypothesized relationships. Meta structural equation modelling (meta‐analytic SEM) was used to analyse the data. The results indicate playfulness, attitude, usefulness, facilitating condition and social influence of the chatbots are the key factors in influencing user adoption. Further, technological characteristics and culture were found to significantly moderate certain relationships in the model. Practical and theoretical implications have also been discussed.
Latin American Social Medicine in Colombia: Violence, neoliberalism, and Buen Vivir
Authors: Laurens Vivian , Abadía‐Barrero César , Hernández Mario 
Published: April 2023

AbstractThis article explores the efforts of Latin American Social Medicine (LASM) scholars/activists to incorporate decolonial approaches to support peace building in Colombia. We draw from our participation in Red SaludPaz (RSP); a network of universities and civil society organizations dedicated to supporting the peace accord, and guided by social medicine and the indigenous epistemology of Buen Vivir. We describe the work of RSP both as researchers and as active participants of this network guided by participatory action research in the tradition of Fals Borda. We ask what challenges are faced by RSP when reflecting on Buen Vivir, and how to understand our own endeavor to examine community‐based projects through Buen Vivir. We have found that RSP's commitment to promote peace has invited LASM scholars/activists to decolonize notions of health and wellbeing and to think about Buen Vivir as a pathway to emancipation from the rigid confines of western epistemology.
Investigation of Rhodnius prolixus head anatomy using microtomography
Authors: Sena Gabriela , da Silva Ademir X. , Nogueira L. P. , Colaço M. V. , Mestcher Brian , Fidalgo G. , Pickler A. , Azambuja P. , Gonzalez M. S. , Mattos D. P , Barroso Regina.Cely. 
Published: April 2023

AbstractIn the last years, microtomography has proved to be a powerful technique on insects’ studies, allowing a detailed view of the structures’ internal with a high resolution. One of the most important advantages about the use of microtomography in these studies is the fact that the dissection is not necessary, which decreases considerably the number of samples used on the insects’ research. Some insects are used constantly in studies about morphology, metamorphosis, and reproduction, because they work as a model for others, and Rhodnius prolixus is one of the most studied in this group. This insect is also one of the main insect vectors of Chagas disease that kills around 12,000 people every year in Latin America. Some studies using laboratory microtomography conventional scanners combining with the correct staining methods have proved that it could be a powerful tool in biological research, allowing the visualisation of low‐density tissues. The main goal of the present work was to use staining protocols to study Rhodnius prolixus with laboratory microtomography conventional scanners. The experiments were carried out at the imaging lab in the Theoretical Biology Department, University of Vienna, using an Xradia MicroXCT and at the University of Oslo, using a Skyscan 2211.
Blood group in relation to oral Fordyce's granules and serum cholesterol level
Authors: Diajil Ameena Ryhan , Goodson Michaela Louise 
Published: April 2023

AbstractBackgroundThe ABO and Rh systems are the most commonly used blood‐group systems used to classify blood group globally. A number of studies have shown that ABO blood groups may be associated with an increased serum cholesterol levels which in turn may be related to the presence of oral Fordyce spots or granules. Oral Fordyce's granules are ectopic sebaceous glands within the oral cavity and are visible through epithelium. The aim of this study was to assess the relationship between ABO and Rhesus blood groups and the presence of oral Fordyce's granules and serum cholesterols level by gender.MethodsFollowing ethical approval and informed consent, 124 subjects were recruited into this cross‐sectional study. Clinical oral examination assessed the number of Fordyce's granules and blood samples were collected to determine the serum cholesterol and ABO/Rh blood‐group systems of individual subjects.ResultsBlood group AB+showed the highest mean of oral Fordyce's granules number and serum cholesterol level but this was not statistically significant compared to other blood groups. Female subjects in this study who were AB+were had significantly higher serum cholesterol levels than males.ConclusionThis study indicates an association between ABO blood group, serum cholesterol level and mean number of oral Fordyce's granules. A larger sample size in a future study is required to ascertain whether number of Fordyce's granules is an important measure of serum cholesterol, but the study does show that for AB+individuals, females may have higher serum cholesterol than males.
Frequency domain identification of modal characteristics and loads from output‐only measurements
Authors: Hwang Jae‐Seung , Kwon Dae Kun , Kareem Ahsan 
Published: April 2023

AbstractThis paper proposes a frequency domain framework for concurrently estimating the modal structural parameters and modal loads from the measured output response. A mathematical load model is theoretically developed and compared to the load determined by force identification. Unlike conventional modal identification schemes, the proposed approach can effectively accommodate the spectral shape of the external load in the frequency domain, enabling the determination of the modal parameters without explicit white noise assumption. The proposed approach is verified by applying it to a single‐degree‐of‐freedom system system representing a modal response, an aeroelastic model in an atmospheric boundary layer wind tunnel, a multi‐degree‐of‐freedom system, and the measured acceleration response of a 40‐story building. The simulation results demonstrate that the proposed technique can reliably estimate the modal parameters and load model and is robust against the noise present in the response and the order of the load model. Additionally, the proposed technique can be applied to various loading conditions such as vortex‐induced and buffeting effects since the modal parameters and the load model can be identified for any shape of the loading spectrum.
Heteroskedasticity‐Robust Standard Errors for Dynamic Panel Data Models with Fixed Effects*
Authors: Han Chirok , Kim Hyoungjong 
Published: April 2023

AbstractFor linear panel data models with fixed effects, cluster‐robust covariance estimation does not use variability over time. The extant heteroskedasticity‐robust methods available under strict exogeneity do not generalize to dynamic models. We propose novel robust covariance estimators under a strong version of serial uncorrelatedness, where serial uncorrelatedness is required to identify dynamic panel models. Asymptotics are established, and simulations verify theoretical findings. The estimator can apply to the popular dynamic IV‐GMM estimators and be a sharper alternative for cluster‐robust covariance estimators in panel data models with limited cross‐sectional information.
Comparison of visual performance between peripheral gradient high‐addition multifocal soft contact lenses and orthokeratology
Authors: Chen Yunyun , Ding Chenglu , Li Xue , Huang Yingying , Zhou Fengchao , Drobe Björn , Chen Hao , Bao Jinhua 
Published: April 2023

AbstractPurposeThe aim of this study was to evaluate the short‐term effects of peripheral gradient high‐addition multifocal soft contact lenses (MFSCLs) and orthokeratology (Ortho‐K lenses) on visual performance in myopic children.MethodsThirty myopic children participated in this prospective study. Each participant wore different sets of lenses in the following sequence: single‐vision spectacles (SVSPs) as a control, MFSCLs and Ortho‐K lenses. Ocular aberrations, topography, high‐contrast visual acuity (HCVA), low‐contrast visual acuity (LCVA) and accommodation of the right eye were measured with each type of correction on a different day.ResultsCompared with SVSPs, high‐addition MFSCLs and Ortho‐K lenses significantly increased all items of aberrations (all p < 0.05) except trefoil (p = 0.17). MFSCLs induced less coma, root mean square of the third‐order aberration (RMS3) and higher order aberrations than Ortho‐K lenses (all p < 0.05). No significant difference in HCVA was found across the three correction types (F = 1.19, p = 0.39). In terms of LCVA, MFSCLs performed significantly poorer than SVSPs (difference, 0.16 logMAR; p = 0.001) and slightly worse than Ortho‐K lenses (difference, 0.08 logMAR; p = 0.35). No significant difference in decentration was found between the two types of contact lenses, and no associations were observed between decentration and visual acuity at both high‐ and low‐contrast levels (all p > 0.05). For MFSCLs, decentration was positively related to coma (r = 0.43, p = 0.02) and RMS3 (r = 0.44, p = 0.02), which was not the case for Ortho‐K lenses. Accommodative facility was worse with MFSCLs than Ortho‐K lenses (p = 0.001).ConclusionMultifocal soft contact lenses differed from Ortho‐K lenses in aberration profile and LCVA, although decentration was similar. Decentration <1 mm had minimal influence on both HCVA and LCVA for either type of correction, but significantly increased third‐order aberrations for MFSCLs, but not Ortho‐K lenses.