bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poorer White Matter Microstructure Predicts Slower and More Variable Reaction Time Performance: Evidence for a Neural Noise Hypothesis in a Large Lifespan Cohort
Authors: McCormick Ethan M. ,   Cambridge Centre for Ageing and Neuroscience, Kievit Rogier A. 
Published: April 2023

Most prior research has focused on characterizing averages in cognition, brain characteristics, or behavior, and attempting to predict differences in these averages among individuals. However, this overwhelming focus on mean levels may leave us with an incomplete picture of what drives individual differences in behavioral phenotypes by ignoring the variability of behavior around an individual's mean. In particular, enhanced white matter (WM) structural microstructure has been hypothesized to support consistent behavioral performance by decreasing Gaussian noise in signal transfer. Conversely, lower indices of WM microstructure are associated with greater within-subject variance in the ability to deploy performance-related resources, especially in clinical populations. We tested a mechanistic account of the “neural noise” hypothesis in a large adult lifespan cohort (Cambridge Centre for Ageing and Neuroscience) with over 2500 adults (ages 18-102; 1508 female; 1173 male; 2681 behavioral sessions; 708 MRI scans) using WM fractional anisotropy to predict mean levels and variability in reaction time performance on a simple behavioral task using a dynamic structural equation model. By modeling robust and reliable individual differences in within-person variability, we found support for a neural noise hypothesis (Kail, 1997), with lower fractional anisotropy predicted individual differences in separable components of behavioral performance estimated using dynamic structural equation model, including slower mean responses and increased variability. These effects remained when including age, suggesting consistent effects of WM microstructure across the adult lifespan unique from concurrent effects of aging. Crucially, we show that variability can be reliably separated from mean performance using advanced modeling tools, enabling tests of distinct hypotheses for each component of performance.SIGNIFICANCE STATEMENTHuman cognitive performance is defined not just by the long-run average, but trial-to-trial variability around that average. However, investigations of cognitive abilities and changes during aging have largely ignored this variability component of behavior. We provide evidence that white matter (WM) microstructure predicts individual differences in mean performance and variability in a sample spanning the adult lifespan (18-102). Unlike prior studies of cognitive performance and variability, we modeled variability directly and distinct from mean performance using a dynamic structural equation model, which allows us to decouple variability from mean performance and other complex features of performance (e.g., autoregression). The effects of WM were robust above the effect of age, highlighting the role of WM in promoting fast and consistent performance.
The fifth element: a novel eIF2α kinase in microglia
Authors: Ruggieri Alessia 
Published: April 2023

The cellular integrated stress response (ISR) is a central signaling pathway that tunes translation initiation in response to a wide range of cellular insults to promote cell survival. The critical node of this regulation involves the phosphorylation of the eukaryotic translation initiation factor 2α (eIF2α) by stress kinases. In this issue of EMBO reports, Wu et al (2023) report FAM69C as a novel eIF2α kinase that promotes ISR activation and stress granule (SG) assembly in microglia in response to oxidative stress. This work proposes a protective role for FAM69C and SGs in limiting damaging inflammatory responses commonly associated with neurodegenerative diseases.
UNIVERSIDADE PÚBLICA, SOCIEDADE CAPITALISTA E PRODUÇÃO DO CONHECIMENTO À LUZ DA PEDAGOGIA HISTÓRICO-CRÍTICA
Authors: SOUSA FRANCISCA MÁRCIA LIMA , COLARES ANSELMO ALENCAR 
Published: April 2023

RESUMO O artigo problematiza a relação entre a universidade pública, a sociedade capitalista e a produção do conhecimento à luz da Pedagogia Histórico-Crítica. Utiliza como referência a formação omnilateral nesta conjuntura de retrocessos agravada pela crise estrutural do capital. A discussão é embasada na proposta da Pedagógica Histórico-Crítica como mediadora da construção do conhecimento. A metodologia consta de estudos bibliográficos realizados durante a disciplina “Pedagogia Histórico-Crítica: ciência, currículo e didática”, ofertada como componente optativo no Programa de Pós-graduação em Educação na Amazônia (PGEDA/Ufopa). O estudo não teve caráter interventivo, porém, buscou demonstrar a implementação da PHC como orientadora da prática educativa em cursos superiores e suas possibilidades concretas para a efetivação de um trabalho pedagógico que esteja voltado para a formação humana integral emancipatória, tendo a universidade pública como um espaço de possível viabilização.
Darülfünundan İstanbul Üniversitesine Resmî İdeolojinin Yükseköğretime Etkisi
Authors: AKINCI Abdulvahap 
Published: April 2023

Modern devletler, vatandaşlarını inşa etmek, onlara bir kimlik vermek için eğitimi araç olarak kullanmıştır. Osmanlı Devleti de Avrupa’daki gelişmelere kayıtsız kalamazdı. Özellikle milliyetçiliğin gelişmesi ve ülkede farklı etnik, dinsel kökenden toplulukları etkilemeye başlaması ve ülkenin parçalanma kaygısı, ortak bir Osmanlı kimliği inşası için adımların atılmasını zorlunlulaştırmıştı.
Bu çalışmanın amacı, Tanzimat döneminden erken Cumhuriyete uzanan süreçte resmî ideolojinin yükseköğretime etkisinin irdelenmesidir. Bu kapsamda, Osmanlı Devleti’nde yükseköğretim sisteminin gelişimi Darülfünun özelinde incelenmiştir. Cumhuriyet dönemiyle, yükseköğretim sistemindeki dönüşüm incelenerek, arkasında yatan ideolojik amaçlar değerlendirilecektir. Nitel araştırmanın tarihsel yönteminden yararlanılan çalışmanın temel bulgusu, Osmanlı ve Cumhuriyet dönemlerinde oluşturulan yükseköğretim kurumlarının dönemin resmî ideolojisini yansıttığıdır.
Are Regionally Calibrated Seismicity Models More Informative than Global Models? Insights from California, New Zealand, and Italy
Authors: Bayona José A. , Savran William H. , Iturrieta Pablo , Gerstenberger Matthew C. , Graham Kenny M. , Marzocchi Warner , Schorlemmer Danijel , Werner Maximilian J. 
Published: April 2023

Abstract
Earthquake forecasting models express hypotheses about seismogenesis that underpin global and regional probabilistic seismic hazard assessments (PSHAs). An implicit assumption is that the comparatively higher spatiotemporal resolution datasets from which regional models are generated lead to more informative seismicity forecasts than global models, which are however calibrated on greater datasets of large earthquakes. Here, we prospectively assess the ability of the Global Earthquake Activity Rate (GEAR1) model and 19 time-independent regional models to forecast M 4.95+ seismicity in California, New Zealand, and Italy from 2014 through 2021, using metrics developed by the Collaboratory for the Study of Earthquake Predictability (CSEP). Our results show that regional models that adaptively smooth small earthquake locations perform best in California and Italy during the evaluation period; however, GEAR1, based on global seismicity and geodesy datasets, performs surprisingly well across all testing regions, ranking first in New Zealand, second in California, and third in Italy. Furthermore, the performance of the models is highly sensitive to spatial smoothing, and the optimal smoothing likely depends on the regional tectonic setting. Acknowledging the limited prospective test data, these results provide preliminary support for using GEAR1 as a global reference M 4.95+ seismicity model that could inform eight-year regional and global PSHAs.
Penanggulangan Stunting pada Anak Usia Dini Melalui Kegiatan Penyuluhan kepada Masyarakat Desa Banyumekar Kabupaten Pandeglang
Authors: Fathonah Woelandari , Mina Enden , Kusuma Rama Indera , Wigati Restu , Putri Salsabilla Meidy Arini , Kuncoro Hendrian Budi Bagus 
Published: April 2023

Faktor utama penyebab terjadinya stunting pada anak usia dini adalah faktor kesehatan dan kecukupan gizi sebelum, masa kehamilan dan sesudah melahirkan yang akan berdampak pada kesehatan dan pertumbuhan anak. Berdasarkan RPJMN 2020-2024 stunting merupakan isu prioritas dalam pembangunan kesehatan, sehingga hal ini yang melatarbelakangi kami mengangkat kegiatan penyuluhan stunting di Desa Banyumekar dengan menghadirkan pemateri dari tenaga kesehatan setempat yang berkompeten. Kegiatan dilaksanakan pada tanggal 18 Januari 2021 dan dihadiri oleh 24 peserta terdiri dari ibu hamil dan ibu yang memiliki anak balita. Tujuan kegiatan pengabdian masyarakat adalah untuk mengedukasi masyarakat melalui penyuluhan stunting sehingga diharapkan dapat menumbuhkan kesadaran masyarakat tentang pentingnya kesehatan dan tumbuh kembang anak, sehingga stunting dapat dicegah sejak dini. Metode yang digunakan pada kegiatan ini adalah penyuluhan stunting berupa sosialisasi bertemakan “Ayo kenali stunting pada anak usia dini” dengan mengundang bidan desa selaku narasumber dari puskesmas setempat. Hasil dari kegiatan ini adalah masyarakat desa antusias mengikuti penyuluhan, mendapatkan ilmu tentang cara memilih bahan makanan yang tinggi vitamin, protein dan karbohidrat untuk menunjang pertumbuhan dan kesehatan anak, sehingga stunting dapat dicegah oleh masyarakat Desa Banyumekar. Diharapkan setelah kegiatan penyuluhan ini, masyarakat dapat menerapkan ilmu yang didapatkan dalam kehidupan sehar-hari, sehingga upaya dalam mencegah stunting dapat direalisasikan.The main factors causing stunting in early childhood are health factors and nutritional adequacy before, during, and after childbirth, which will impact children's health and growth. Based on the 2020-2024 RPJMN, stunting is a priority issue in health development. This is the background for us to raise stunting counselling activities in Banyumekar village by presenting speakers from competent local health workers. Community service activities aim to educate the community through stunting counselling. It is expected to raise public awareness about the importance of health and child development so that stunting can be prevented early. The method used in this activity is stunting counselling in the form of socialization with the theme "Let's recognize stunting in early childhood" by inviting village midwives from local health centers as resource persons. The result of this activity is that the village community is enthusiastic about participating in the counselling and gaining knowledge about vitamins, protein and carbohydrates to support the growth and health of children so that the people of Banyumekar village can choose to stunt. It is hoped that after this outreach activity, the community can apply the knowledge gained in everyday life so that efforts to prevent stunting can be realized.
Pemberdayaan Ibu Rumah Tangga Melalui Pelatihan Pembuatan Tas Talikur
Authors: As'ad Ihwana , Magga Hermin Andi , Radjawane Louise Elizabeth , Arthawati Sri Ndaru , Adawiyah Sa'diyah El 
Published: April 2023

Pengabdian kepada Masyarakat (PKM) diselenggarakan di kantor Desa ma’rumpa, Kecamatan Marusu, Kabupaten Maros, dengan mitra pengabdian adalah kelompok ibu-ibu PKK yang berlangsung selama dua hari yaitu pada tanggal 16 dan 17 November 2022. Kegiatan ini bertujuan untuk memberikan keterampilan dengan materi cara membuat tas tali kur dan cara pemasarannya. Metode ceramah dan praktik langsung oleh peserta membuat efektif dari pelaksanaan pelatihan ini. Hasil dari pengabdian ini adalah peserta yang berjumlah 20 orang mampu membuat tas tali kur dengan motif dasar yang telah diajarkan oleh tim pengabdian. Di hari pertama peserta belajar tentang dasar menyimpul dilanjutkan dengan membuat tas, kemudian di hari kedua dilakukan finishing dengan menambah lapisan serta penutup tas, dan terakhir pemberian materi cara menjual secara online.The community service was held at the Ma'rumpa Village office, Marusu District, Maros Regency, with the dedication partner being a group of PKK mothers which lasted for two days, on 16 and 17 November 2022. This activity aims to provide skills with materials for making and marketing tali kur bags. The participants' lecture method and hands-on practice made implementing this training effective. The result of this dedication was that 20 participants could make tali kur bags with the basic motifs that the service team had taught. On the first day, participants learn about the basics of knotting, followed by making bags, then on the second day finishing by adding layers and bag covers and finally providing material on how to sell online.
Antioxidant and Antiproliferative Activities of Methanol Extract from Melaleuca cajuputi subsp. Cumingiana [Turcz.] Fruit
Authors: Isnaini Isnaini , Achmadiyah Rosinta Dewi , Awaeh Gelvia , Khatimah Husnul , Yasmina Alfi 
Published: April 2023

Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow (M. cajuputi) is a plant that is easily found in Banjarmasin. M. cajuputi contains phytochemical compounds in the form of polyphenols including flavonoids, quinons, saponins, and alkaloids that are thought to have antioxidant and antiproliferation activities. The aim of this research was to find out analyze antioxidant and antiproliferation activity of M. cajuputi fruit methanol extract. The antioxidant activity was tested using the DPPH method. The activities were observed in IC50 and were measured using the UV-VIS spectrophotometer at a wavelength of 517 nm. To test the antiproliferation, true experimental with post-test was applied in this research. Animal used in this study were 30 mature zebras (length > 2.5 cm) which were grouped into 4, namely the negative control group (DMSO 0.05%), the methanol extract group of M. cajuputi with concentrations of 18.5 ppm, 37 ppm and 74 ppm. The bound variable in this study was antiproliferation activity in the tail of an amputated fish. Data analysis was measured by one-way ANOVA and Post-Hoc Tukey HSD tests. Phytochemical results obtained the presence of phenol compounds, cuinons, flavonoids, alkaloids, saponins, tannins, steroids and terpenoids. Methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit was at IC50 of 15.50 ppm (95% CI 8.31- 32.72). The antiproliferation activity of zebrafish tails increased in the administration of fruit extract Melaleuca cajuputi subsp. Cumingiana [Turcz.] Barlow in consentration of 74 ppm (p<0.05), both on day 4 and day 8 of measurement when compared to negative controls. It can be concluded that methanol extract of Melaleuca cajuputi subsp Cumingiana [Turcz.] Barlow fruit has antiproliferative activity against the growth of amputated zebrafish tails.
PENGEMBANGAN SOAL MATEMATIKA MODEL PISA LEVEL 6 MENGGUNAKAN KONTEKS LAHAN BASAH
Authors: Anshari Ahmad Mujib , Pasani Chairil Faif , Noorbaiti Rahmita 
Published: April 2023

Pengembangan yang dilakukan dalam penelitian ini bertujuan untuk menghasilkan instrumen soal matematika model PISA level 6 dengan konteks lahan basah yang valid serta mengukur tingkat keterbacaan dan kepraktisan instrumen tersebut. Peneliti mengambil sampel siswa Kelas IX G di SMPN 1 Banjarmasin dalam penelitian ini. Peneliti menggunakan metode riset pengembangan atau development research tipe formative evaluation sebagai metode penelitian. Tahapan dalam riset ini diantaranya tahap preliminary terdiri dari persiapan serta tahap formative evaluation yang terdiri dari evaluasi pribadi, uji pakar ahli, one-to-one dan small group. Penelitian ini belum dilakukan sampai tahap field test yaitu pengujian terhadap kemampuan siswa. Metode analisis yang digunakan adalah analisis deskriptif dengan merevisi berdasarkan catatan validator serta saran dan komentar dari siswa. Sarana yang digunakan untuk mendapatkan data pada penelitian ini berupa lembar validasi dan lembar angket siswa. Hasil Penelitian ini menghasilkan tingkat kevalidan dengan kategori valid adalah sebesar 3,4948. Hasil analisis tingkat kepraktisan soal sangat praktis dengan skor 3,52.
Acute Kidney Injury because of Implanted Tobramycin Pellets
Authors: Windfeld-Mathiasen Josefine , Horwitz Henrik , Schwartz Frederik 
Published: April 2023

Case:
A 50-year-old healthy man with normal kidney function underwent surgery for fracture-related infection. Unfortunately, the patient received 2.5 times the intended dose of tobramycin pellets in the medullary cavity and developed acute kidney failure. Given the intraosseous administration of tobramycin, the drug displayed an absorption-dependent pharmacokinetics and multiple treatments with hemodialysis were needed. However, the patient had a complete recovery, and the kidney function remained normal at the 2-year follow-up.

Conclusion:
Tobramycin pellets are nephrotoxic in supratherapeutic doses; however, it was reversible in this case. Owing to the intraosseous administration, multiple treatments with hemodialysis were required.
Illegal Ministerial Circulars in Indonesia: Implications for Legitimacy
Authors: Gunawan Ari , Susetio Wasis , Markoni Markoni , Subiyanto Achmad Edi 
Published: April 2023

This normative research aimed to examine the extent of ministerial circular letters in Indonesia and whether a particular circular letter violates the Law Number 17 of 2014. Through a qualitative literature review and legal analysis, the study found that Minister of Finance Circular Letter Number S-841/Mk.02/2014 does not fall under the category of legislative rules and lacks external application, thus rendering it illegal. The study suggests that ministerial circular letters must adhere to the law, philosophy, and social considerations to be considered legitimate. The findings have implications for the proper implementation and interpretation of ministerial circular letters in Indonesia.
Highlights:

Ministerial circular letters in Indonesia must comply with the law, philosophical principles, and social considerations to be considered legitimate.
Ministerial circular letters are not regulations that apply to the general public, but only to ministries or institutions.
Ministerial circular letters that contradict higher laws are considered illegal.
The Elusive Justice: Analyzing Disparities in Judges' Decisions on Domestic Psychic Violence Cases
Authors: Liong Steven , Helvis Helvis , Markoni Markoni , Kantikha I Made 
Published: April 2023

This study aimed to analyze the basis for judges' considerations in cases of domestic psychological violence and to examine the causes of disparities in judges' decisions. The research employed a normative juridical research method. The results showed that judges' considerations in domestic psychological violence cases were based on three factors: juridical, sociological, and ideal philosophical considerations, which resulted in different decisions. The study found that disparities in judges' decisions could not be eliminated due to various influencing factors. Nonetheless, the act of psychological violence is considered a crime that disturbs family harmony and is prohibited by Law No. 23 of 2004. This research has implications for the need to establish clear guidelines for judges in handling domestic psychological violence cases to ensure consistency and fairness in the legal system.
Highlights:

The judge's considerations in domestic psychological violence cases include juridical, sociological, and ideal philosophical aspects.
Different considerations can result in different decisions, even in similar cases.
Acts of psychological violence in the household are prohibited by Law No. 23 of 2004 and can disrupt family harmony.
An Improved hybrid Salp Swarm Optimization and African Vulture Optimization Algorithm for Global Optimization Problems and Its Applications in Stock Market Prediction
Authors: Alizadeh Ali , Gharehchopogh Farhad Soleimanian , Masdari Mohammad , Jafarian Ahmad 
Published: April 2023

Abstract
Optimization is necessary for solving and improving the solution of various complex problems. Every meta-heuristic algorithm can have a weak point, and multiple mechanisms and methods can be used to overcome these weaknesses. We can use hybrid meta-heuristic algorithms to arrive at an efficient algorithm. This paper presents a new and intelligent approach by hybridizing meta-heuristic algorithms and using different mechanisms simultaneously without significantly increasing the time complexity. For this purpose, two algorithms, Salp Swarm Optimization(SSO) and the African Vulture Optimization Algorithm (AVOA) have been hybridized. And to improve the optimization process of the Modified Choice Function and Learning Automata mechanisms. In addition, two other improving mechanisms, named Opposition-Based Learning (OBL) and β-hill climbing (BHC) technique, have been presented and integrated with the AVOA-SSA algorithm. Fifty-two standard benchmarks were used to test and evaluate the AVOA-SSA algorithm. Finally, an improved version of the Extreme Learning Machine(ELM) classifier has been used with real stock market data for stock market prediction. The obtained results indicate the excellent and acceptable performance of the AVOA-SSA algorithm in `solving optimization problems and has been able to achieve high-quality solutions.
End-ischemic Hypothermic Oxygenated Perfusion for Extended Criteria Donors in Liver Transplantation – A multicenter, randomized controlled trial - HOPExt
Authors: Pradat Pierre , Pantel Solène , Maynard Marianne , Lalande Laure , Thevenon Sylvie , Adam René , Allard Marc-Antoine < , Robin Fabien , Rayar Michel , BOLESLAWSKI Emmanuel , Scatton Olivier , Chirica Mircea , Faitot François , Bachellier Philippe , Soubrane Olivier , Mohkam Kayvan , Mabrut Jean-Yves , Lesurtel Mickaël 
Published: April 2023

Abstract
Background: Given the scarce donor supply, an
increasing number of so-called marginal or extended criteria donor
(ECD) organs are used for liver transplantation. These
ECD liver grafts are however known to be associated with a higher
rate of early allograft dysfunction and primary non-function
because of a greater vulnerability to ischemia-reperfusion injury.
The end-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE)
technique may improve outcomes of liver transplantation with ECD
grafts by decreasing reperfusion injury.
Methods: HOPExt trial is a
comparative open-label, multicenter, national, prospective,
randomized, controlled study, in two parallel groups,
using static cold storage, the gold standard
procedure, as control. The trial will enroll adult patients on
the transplant waiting list for liver failure or liver cirrhosis
and/or liver malignancy requiring liver transplantation and
receiving an ECD liver graft from a brain-dead donor. In the
experimental group, ECD liver grafts will first undergo a classical
static cold (4°C) storage followed by a hypothermic oxygenated
perfusion (HOPE) for a period of 1 to 4 hours. The control group
will consist of the classic static cold storage which is
the gold standard procedure in liver transplantation. The primary
objective of this trial is to study the efficacy of HOPE used
before transplantation of ECD liver grafts from brain-dead donors
in reducing postoperative early allograft dysfunction within the
first 7 postoperative days compared to simple cold static
storage.
Discussion: We present in this protocol all
study procedures in regard to the achievement of the HOPExt trial,
to prevent biased analysis of trial outcomes and improve the
transparency of the trial results. Enrollment of patients in the
HOPExt trial has started on June 31, 2021, and is ongoing
Trial registration: ClinicalTrials.gov
NCT03929523. Registered on April 29, 2019, before the start of
inclusion.