bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vector autoregression: Useful in rare diseases?—Predicting organ response patterns in a rare case of secondary AA amyloidosis
Authors: Ihne-Schubert Sandra M. , Kircher Malte , Werner Rudolf A. , Lapa Constantin , Einsele Hermann , Geier Andreas , Schubert Torben 
Published: August 2023

Background
Statistical analyses of clinical data are a cornerstone in understanding pathomechanisms of disorders. In rare disorders, cross-sectional datasets of sufficient size are usually not available. Taking AA amyloidosis as an example of a life-threatening rare disorder resulting from of uncontrolled chronic inflammation, we propose techniques from time series analysis to predict organ response to treatment. The advantage of time-series analysis is that it solely relies on temporal variation and therefore allows analyzing organ response to treatment even when the cross-sectional dimension is small.

Methods
The joint temporal interdependence of inflammatory activity and organ response was modelled multivariately using vector autoregression (VAR) based on a unique 4.5 year spanning data set of routine laboratory, imaging data (e.g., 18F-Florbetaben-PET/CT) and functional investigations of a 68-year-old patient with multi-organ involvement of AA amyloidosis due to ongoing inflammatory activity of a malignant paraganglioma in stable disease for >20 years and excellent response to tocilizumab).

Results
VAR analysis showed that alterations in inflammatory activity forecasted alkaline phosphatase (AP). AP levels, but not inflammatory activity at the previous measurement time point predicted proteinuria.

Conclusion
We demonstrate the feasibility and value of time series analysis for obtaining clinically reliable information when the rarity of a disease prevents conventional prognostic modelling approaches. We illustrate the comparative utility of blood, functional and imaging markers to monitor the development and regression of AA amyloidosis.
ICU stays that are judged to be non-beneficial: A qualitative study of the perception of nursing staff
Authors: Mathey Lucas , Jacquier Marine , Meunier-Beillard Nicolas , Andreu Pascal , Roudaut Jean-Baptiste , Labruyère Marie , Rigaud Jean-Philippe , Quenot Jean-Pierre , Ecarnot Fiona 
Published: August 2023

Introduction
Non-beneficial stays in the intensive care unit (ICU) may have repercussions for patients and their families, but can also cause suffering among the nursing staff. We aimed explore the perceptions of nursing staff in the ICU about patient stays that are deemed to be “non-beneficial” for the patient, to identify areas amenable to intervention, with a view to improving how the nursing staff perceive the patient pathway before, during and after intensive care.

Methods
Multicentre, qualitative study using individual, semi-structured interviews. All qualified nurses and nurses’ aides who were full-time employees in the ICU of three participating centres were invited to participate. Interviews were recorded, transcribed and analyzed using textual content analysis.

Results
A total of 21 interviews were performed from February 2020 to October 2021, at which point saturation was reached in the data. Average age of participants was 38.5±7.5 years, and they had an average of 10.7±7.4 years of experience working in the ICU. Four major themes emerged from the interviews, namely: (1) the work is oriented towards life-threatening emergencies, technical procedures and burdensome care; (2) a range of specific criteria and circumstances influence the decisions to admit patients to ICU; (3) there are significant organisational, physical and psychological repercussions associated with a non-beneficial stay in the ICU; (4) respondents made some proposals for improvements to the patient care pathway.

Conclusion
Nursing staff have a similar perception to physicians regarding admission decisions and non-beneficial ICU stays. The possibility of future ICU admission needs to be anticipated, discussed systematically with patients and integrated into healthcare goals that are consistent with the patient’s wishes and preferences, in multi-professional collaboration including nursing and medical staff.
Immunotherapy and Transarterial Radioembolization Combination Treatment for Advanced Hepatocellular Carcinoma
Authors: Yeo Yee Hui , Liang Jeff , Lauzon Marie , Luu Michael , Noureddin Mazen , Ayoub Walid , Kuo Alexander , Sankar Kamya , Gong Jun , Hendifar Andrew , Osipov Arsen , Friedman Marc L. , Lipshutz H. Gabriel , Steinberger Jonathan , Kosari Kambiz , Nissen Nicholas , Abou-Alfa Ghassan K. , Singal Amit G. , Yang Ju Dong 
Published: August 2023

INTRODUCTION:
The efficacy and safety of combined immunotherapy and transarterial radioembolization (TARE) were suggested in preclinical and early-phase trials, but these were limited by small sample sizes. We sought to compare the efficacy of combined therapy and immunotherapy alone in patients with advanced hepatocellular carcinoma (HCC).

METHODS:
The National Cancer Database was used to identify patients with advanced HCC diagnosed between January 1, 2017, and December 31, 2019. We included patients who received combined therapy or immunotherapy alone as first-line treatment. Multivariable logistic regression was conducted to determine predictors of combined therapy. Kaplan-Meier and Cox regression approaches were used to identify predictors of overall survival and to compare hazards of mortality between the patients who received combined therapy and immunotherapy alone.

RESULTS:
Of 1,664 eligible patients with advanced-stage HCC, 142 received combined TARE/immunotherapy and 1,522 received immunotherapy alone. Receipt of combination therapy was associated with care at an academic center and inversely associated with racial/ethnic minority status (Hispanic and Black individuals). The median overall survival was significantly higher in the combination group than in the immunotherapy alone group (19.8 vs 9.5 months). In multivariable analysis, combined therapy was independently associated with reduced mortality (adjusted hazard ratio 0.50, 95% confidence interval: 0.36–0.68, P < 0.001). Results were consistent across subgroups and in sensitivity analyses using propensity score matching and inverse probability of treatment weighting.

DISCUSSION:
The combination of TARE and immunotherapy was associated with improved survival compared with immunotherapy alone in patients with advanced-stage HCC. Our findings underly the importance of large clinical trials evaluating combination therapy in these patients.
Prevalence and predictors of tobacco, alcohol and illicit drug experimentation among Tunisian middle and high school-adolescents
Authors: Amara Amel , Omri Nihel , Sahli Jihene , Zedini Chakib , El Ouni Tasnim , Mtiraoui Ali , Mallouli Manel , Ghardalou Mariem 
Published: August 2023

Abstract

Objectives
Psychoactive substance experimentation among Tunisian adolescents remains one of the most threatening public health concerns. In spite of this, little is known about the prevalence and predictors of these behaviors in the Tunisian context. This study aims to assess the prevalence of tobacco, alcohol and illicit drug experimentation and its predictive factors among adolescents in the delegation of Nfidha, Sousse governorate, Tunisia.

Methods
We conducted a cross sectional study in middle and high schools in the delegation of Nfidha, Sousse governorate, Tunisia, during the first trimester of the 2019–2020 school year using an anonymous questionnaire self-administered to a randomly drawn representative sample of 1,352 pupils. Data collected included socio-demographic characteristics, substance experimentation among school-adolescents, academic performance as well as family and peer’ factors.

Results
Tobacco was the most commonly experimented substance with a prevalence rate of 17.5 % (CI 95 %: 14.8–18.8 %). The prevalence of alcohol and illicit drugs use were 3.3 % [CI 95 %: (2.1–3.9 %)] and 2 % [CI 95 %: (1.1–2.6 %)] respectively. Being male (Adjusted (AOR)=4.09, p<0.001), being a high school pupil (AOR=2.81, p<0.001), having experiencing academic failure (AOR=1.60, p=0.007) and having a father and siblings who use tobacco (AOR=1.72, p=0.002; AOR=2.03, p=0.001 respectively) were the predictors of tobacco experimentation in the multivariate logistic regression analysis. Additionally, being male (AOR=8.40, p<0.001), having experienced academic failure (AOR=2.76, p=0.017) as well as having a father and siblings who use alcohol (AOR=5.90, p<0.001; AOR=3.03, p=0.045 respectively) and having experienced tobacco (AOR=4.28, p<0.001) were the determinants of alcohol experimentation. Similarly, having a history of academic failure (AOR=3.44, p=0.041), having peers who use illicit drugs (AOR=3.22, p=0.028), having a history of tobacco and alcohol experimentation (AOR=6.52, p<0.001; AOR=3.49, p=0.046 respectively) were the predictors of illicit drug experimentation among adolescents.

Conclusions
A substantial number of socio-demographic and environmental factors have been identified as being involved in experimentation with psychoactive substance during adolescence. Therefore, further prevention programs targeting not only adolescents, but also all risk factors are needed.
Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation
Authors: Yee Lim Sin , Abu Bakar Mohd Fadzelly , Abdullah Norazlin , Abu Bakar Fazleen Izzany , Fatmawati Sri 
Published: August 2023

Abstract

Objectives
An increase in gout prevalence has drawn attention among society and this situation drives the exploration of more favourable treatment using traditional medicinal plants which are rich in phenolic and flavonoid to avoid the side effects of modern medication. However, there are only few studies regarding the optimization of phytochemicals and anti-gout properties of medicinal plants and their combinations. The objectives of this study were to determine the optimal formulation of Strobilanthes crispus, Orthosiphon stamineus Benth and Stevia rebaudiana with maximum total phenolic and flavonoid contents as well as minimum IC50 of in vitro xanthine oxidase inhibitory activity and to examine their correlations among the formulations.

Methods
Plant extracts from hot water infusion were tested for the total phenolic content, total flavonoid content and enzyme inhibition through Folin-ciocalteu assay, aluminium chloride method and xanthine oxidase inhibition assay, respectively. Simplex-centroid mixture design was applied in this study and 13 polyherbal formulations were generated by Design Expert Software.

Results
Linear, special cubic and quadratic models were selected to describe the interaction effect between polyherbal formulations and their responses. Low IC50 value (13.90 μg/mL) of xanthine oxidase activity was found in the binary combination of O. stamineus and S. rebaudiana and this probably related to its high phenolic and flavonoid contents as xanthine oxidase inhibition and phytochemicals were correlated.

Conclusions
The suggested optimal formulation was comprised of 44.26 % O. stamineus and 55.74 % S. rebaudiana and it could be developed as an alternative treatment for gout.
Zur Methode der Leuenberger Konkordie
Authors: Põder Thomas-Andreas 
Published: August 2023

Zusammenfassung
Die Klärung der Signifikanz der Methode der Leuenberger Konkordie verlangt von sich aus nach einer Berücksichtigung des Lebens der Kirchengemeinschaft, das durch diese Methode vermittelt und strukturiert ist. Der Beitrag betrachtet das Ziel, den Grund und das Motiv der Konkordie. Es wird die Erklärung und Verwirklichung der Kirchengemeinschaft kommentiert und ein Blick auf die Methode der Konkordie in den späteren Lehrgesprächsergebnissen geworfen.
Die Gemeinschaft Evangelischer Kirchen in Europa als politischer und gesellschaftlicher Akteur auf europäischer Ebene: gesellschaftsrelevant und zukunftsweisend?
Authors: Parmentier Elisabeth 
Published: August 2023

Zusammenfassung
Die Gemeinschaft Evangelischer Kirchen in Europa (GEKE) sah sich durch die Leuenberger Konkordie vor 50 Jahren dazu verpflichtet, als Kirchengemeinschaft einzustehen für eine “möglichst große Gemeinsamkeit in Zeugnis und Dienst an der Welt“ (§ 29). Dieser Beitrag untersucht fünf Profile der GEKE im Hinblick auf ihre schon effektive Versöhnungsarbeit, auf ihre Wandelbarkeit durch die Jahre und ihr Potential in der heutigen bedrohten Zukunft.
Die Leuenberger Konkordie/die GEKE als ökumenisches Modell? Eine katholische Perspektive
Authors: Hallensleben Barbara 
Published: August 2023

Zusammenfassung
Der Beitrag zeigt, warum die Kirchengemeinschaft der Leuenberger Konkordie und der GEKE nicht als katholisches Modell übernommen werden kann. Die innerprotestantische, v. a. lutherische Kritik an der Leuenberger Konkordie entspricht wesentlich den katholischen Anfragen. Während die GEKE „Grund“ und „Gestalt“ der Kirche unterscheidet, geht die katholische Sicht von der sakramentalen „Grundgestalt“ der einen und einzigen Kirche Jesu Christi aus, die in das Heilshandeln des dreieinen Gottes einbezogen ist.
Recontextualization of the arguments of ‘innocence’ by a football club on Turkish newsprint media
Authors: Kökpınar Kaya Emel , Yağlı Emre 
Published: August 2023

Abstract
We explore the media representation of the involvement of Fenerbahçe, a football club in Türkiye, in the 2011 Turkish Sports Corruption Scandal. Specifically, the study focuses on the discursive construction of Fenerbahçe’s ‘innocence’ and ‘corruption’ through the central arguments of Fenerbahçe’s self-defense and how the newsprint media represents these arguments of innocence in Türkiye. The data consist of the council board speech of the club’s president after his release, the front-page headlines, and the news reports of Turkish daily newspapers featuring the speech. In the study, adopting the critical discourse analysis framework, we discuss that the newspapers either recontextualize the innocence arguments or set them aside to pursue their ideological stances. Besides, our analysis reveals that the newspapers ultimately ignore Fenerbahçe’s arguments about the existence of a secret criminal organization endeavoring to gain control of Fenerbahçe via match-fixing claims and the state via a civil coup.
E-Court Paradigm Shift: Problems of Legitimacy Mechanisms of Electronic Evidence in State Administrative Procedure Law
Authors: Setiawan Hafizh Daffa , Khon Dennis Wye Keen 
Published: August 2023

The existence of electronic information electronic documents has been recognized as valid evidence and is a continuation of the evidence in the applicable Procedural Law in Indonesia, that electronic information and/or electronic documents use electronic systems with the provisions of Law Number 19 of 2016 which amends Law Number 11 of 2008 concerning ITE. The writing focuses on highlighting two legal issues related to the submission of electronic evidence in the e-court evidentiary system, namely regarding the problems faced in efforts to legitimize electronic evidence in proving a case and a proportional mechanism facing the problem of the legitimacy of electronic evidence The complete discussion of electronic courts which includes the evidentiary stage has not taken place due to various obstacles, among others, regulation, availability of supporting facilities and human resources (HR). The study of this legal issue is important in order to optimize the work of electronic justice, so that the modernization of the judicial system is carried out more quickly with an IT approach, if only to realize the vision of the Supreme Court and ensure better access to justice in the future. As a result of this study, it was concluded that the validation process of electronic evidence in electronic evidence is an important stage that cannot be excluded in determining the validity of electronic evidence and the importance of strict digital judicial procedures in the process of validating electronic evidence.
Multilingualism in Europe among to some theoretical and empirical examples – Introduction to a thematic issue
Authors: Sebestyén Krisztina , Jagielska Katarzyna , Comes Nadine 
Published: August 2023

AbstractIn the globalized world, not only one's language plays an increasingly important role, but also the knowledge of other foreign language(s) and their associated culture(s). With their help, a person can obtain various information, which can help them become more informed about the world. Furthermore, they can help gain personal or professional success through foreign language and cultural experience during their studies, scholarships or employment (Sebestyén 2022). Therefore, in 2002, the European Union set the goal of achieving that all its citizens shall know two other foreign languages besides their mother tongue (Kommission der Europäischen Gemeinschaften 2005). Thus, the aim of our thematic issue is to provide an insight into the current situation through a few examples after 20 years since the decision of the European Union was made.
Abnormal frontostriatal connectivity and serotonin function in gambling disorder: A preliminary exploratory study
Authors: Bellmunt-Gil Albert , Majuri Joonas , Arponen Eveliina , Kaasinen Valtteri , Joutsa Juho 
Published: August 2023

AbstractBackgroundThe neurobiological mechanisms of gambling disorder are not yet fully characterized, limiting the development of treatments. Defects in frontostriatal connections have been shown to play a major role in substance use disorders, but data on behavioral addictions, such as gambling disorder, are scarce. The aim of this study was to 1) investigate whether gambling disorder is associated with abnormal frontostriatal connectivity and 2) characterize the key neurotransmitter systems underlying the connectivity abnormalities.MethodsFifteen individuals with gambling disorder and 17 matched healthy controls were studied with resting-state functional connectivity MRI and three brain positron emission tomography scans, investigating dopamine (18F-FDOPA), opioid (11C-carfentanil) and serotonin (11C-MADAM) function. Frontostriatal connectivity was investigated using striatal seed-to-voxel connectivity and compared between the groups. Neurotransmitter systems underlying the identified connectivity differences were investigated using region-of-interest and voxelwise approaches.ResultsIndividuals with gambling disorder showed loss of functional connectivity between the right nucleus accumbens (NAcc) and a region in the right dorsolateral prefrontal cortex (DLPFC) (PFWE <0.05). Similarly, there was a significant Group x right NAcc interaction in right DLPFC 11C-MADAM binding (p = 0.03) but not in 18F-FDOPA uptake or 11C-carfentanil binding. This was confirmed in voxelwise analyses showing a widespread Group x right NAcc interaction in the prefrontal cortex 11C-MADAM binding (PFWE <0.05). Right NAcc 11C-MADAM binding potential correlated with attentional impulsivity in individuals with gambling disorder (r = −0.73, p = 0.005).DiscussionGambling disorder is associated with right hemisphere abnormal frontostriatal connectivity and serotonergic function. These findings will contribute to understanding the neurobiological mechanism and may help identify potential treatment targets for gambling disorder.
Gender variation in indeclinable inanimate nouns and gender markedness in modern Russian
Authors: Chuprinko Kirill , Magomedova Varvara , Slioussar Natalia 
Published: August 2023

AbstractIn this paper, the results of a large web-corpus study on gender of Russian inanimate indeclinable common nouns are presented. In most cases, neuter is assigned to indeclinables as a default. However, morphophonological and semantic analogy may lead to feminine and masculine gender assignment. An extensive variation is observed in the whole group of indeclinables and for particular words, which is much larger than anything that can be found in indeclinable nouns. These data support the idea that both masculine and neuter genders have a special status in the Russian gender system (Magomedova & Slioussar 2023). Masculine tends to be chosen in case of conflicting gender cues. When there are no strong cues pointing to any gender, neuter is assigned as the default option. The results of the study are hardly compatible with various structural approaches to gender assignment, but can be accounted for in competition-based models.
Caminar el territorio, sentipensando y conectando identidades: una experiencia de educación en biodiversidad para su valoración
Authors: Lozano Espinosa Luz Adriana 
Published: August 2023

“Todas las profecías cuentan que el hombre creará su propia destrucción. Pero los siglos y la vida que siempre se renueva engendraron también una generación de amadores y soñadores; hombres y mujeres que no soñaron con la destrucción del mundo, sino con la construcción del mundo de las mariposas y los ruiseñores.”
Gioconda Belli, 2011.
Analysis of the issues that emerged in the revision of the national social studies curriculum in South Korea: Text mining and semantic network analysis of the comments at the public hearing on YouTube
Authors: Cho Chul-Ki , Kim HyeSook , Lee Soyoung 
Published: August 2023

In South Korea, curriculum is revised, made public and implemented under a system known as a nation led curriculum. The South Korean national curriculum was completely revised 10 times between 1946 and 2015. At present, a complete revision is underway to replace the current 2015 national curriculum which is called the 2022 revised national curriculum. This study aims to analyze stakeholders’ responses to the YouTube public hearing on social studies curriculum according to the 2022 revised national curriculum in South Korea in order to understand the context and causes of the issues that emerged. Text mining, semantic network analysis and word cloud techniques were employed to identify issues. As a result, three issues were identified in the social studies curriculum: the balanced development of general elective subjects in high school; the separation of social sciences and geography and division of textbooks in middle school social studies and the separate listing of four subjects, specifically geography, social sciences, history and morals. The issues revealed in this study provide beneficial implications for future social studies curriculum development, revision as well as the development of future research.