bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser ablative patterning of B4C and MoAlB ceramics for hydrophobic surfaces
Authors: Ruiz Samuel , Yoo Yongchul , Wadle Luke , Chen Xin , Li Nan , Lu Yongfeng , Wohl Christopher J. , Wiesner Valerie , Cui Bai 
Published: June 2023

AbstractThrough a novel laser ablative patterning (LAP) process, the present work reported the increase in wetting contact angle of two ceramic materials, boron carbide (B4C) and molybdenum aluminum boride (MoAlB). The LAP technique employed picosecond laser pulses to form a crosshatch pattern with micropillars on ceramic surfaces. The wetting behavior of both ceramic surfaces was successfully transitioned from hydrophilic (θ < 90°) to hydrophobic (θ > 90°), which was related to Wenzel and Cassie–Baxter mechanisms. Parameters such as laser fluence and number of laser scans were varied to study their effects on ceramic surface characteristics. Lunar dust adhesion experiments were performed on these hydrophobic ceramic surfaces, which showed that the adhesion of lunar soil simulant dust particles was significantly reduced in the patterned B4C and MoAlB surfaces.
Strategy for improving the capacity and rate performance of LiNixCoyMn1−x−y electrode using Ti3C2Tx MXene additives
Authors: Ahn Yunhee , Kim Seulgi , Yuk Seoyeon , Hong Seokjae , Kim Hyungsub , Lee Dongju 
Published: June 2023

AbstractWith the expanding range of applications for lithium‐ion batteries, a great deal of research is being conducted to improve their capacity, stability, and charge/discharge rates. This study was performed to investigate the effects of MXene, which has a large surface area and metallic conductivity, as a conductive additive to the cathode, on electrochemical performance. The two‐dimensional material MXene constructs a conductive network with zero‐dimensional carbon black in plane‐to‐point mode to improve conductivity and contact area with active materials, thereby facilitating fast charge transfer. The conductive network reduces the internal resistance and polarization of the cathode and aids the diffusion of electrons. The electrode containing an appropriate amount of MXene showed improved rate performance, high discharge capacity (123.9 mAh g−1 at 4 C), and excellent cycle stability at a high scan rate (125.8 mAh g−1 at 2 C after 150 cycles) compared to pristine electrodes. Based on these results, Ti3C2Tx MXene is a promising conductive additive in the battery field.
Aprocitentan: A new development of resistant hypertension
Authors: Yao Yao , Fan Bin , Yang Bin , Jia Zixuan , Li Bao 
Published: June 2023

AbstractAs the blood pressure threshold for commencing antihypertensive treatment diminishes, the cohort suffering from resistant hypertension (RH) correspondingly expands. Notwithstanding the availability of known antihypertensive medications, there exists a conspicuous lacuna in therapeutic options specifically intended for the management of RH. Currently, aprocitentan is the sole endothelin receptor antagonist (ERA) under development for addressing this pressing clinical challenge. Aprocitentan (ACT‐132577), deriving its active form as a metabolite of macitentan, demonstrates oral potency as a dual endothelin (ET) receptor antagonist. This compound effectively obstructs the binding of endothelin‐1 (ET‐1) to both ETA and ETB receptors, exhibiting an inhibitory potency ratio of 1:16. Clinical investigation of aprocitentan has advanced to phase 3 trials, yielding promising preliminary outcomes.
Pericardial fat and cardiovascular diseases: A systematic review and meta‐analysis
Authors: Al‐Makhamreh Hanna K. , Toubasi Ahmad A. , Al‐Harasis Layla M. , Albustanji Farah H. , Al‐Sayegh Thuraya N. , Al‐Harasis Sarah M. 
Published: June 2023

AbstractObjectivePrevious studies investigated the effect of pericardial fat on cardiovascular diseases. However, until now there was no systematic review and meta‐analysis investigated this association, thus we conducted this article to assess the relationship between pericardial fat and cardiovascular diseases.MethodsWe searched PubMed, The Cochrane Library, Scopus, Google Scholar and Clinicaltrials.gov to select observational studies reported the relationship between pericardial fat and cardiovascular diseases including coronary artery disease (CAD), ventricular dysfunction, heart failure (HF), atrial fibrillation (AF), major adverse cardiac events (MACE), coronary artery calcifications (CAC), arrhythmias other than atrial fibrillation, and cardiovascular events prediction scores. Meta XL 5.3 was used for data analysis.ResultsA total of 83 articles that included 73,934 patients were included in our analysis. The results showed that pericardial fat was significantly associated with CAD (OR = 1.38; 95% CI: 1.28–1.50), ventricular dysfunction (OR = 1.53 per 1 mm3; 95% CI: 1.17–2.01), HF (OR = 1.32 per 1 mm3; 95% CI: 1.23–1.41), AF (OR = 1.16 per 1 mm3; 95% CI: 1.09–1.24), MACE (OR = 1.39 per 1 mm3; 95% CI: 1.22–1.57), and CAC (OR = 1.15 per 1 mm3; 95% CI: 1.05–1.27). On the other hand, there was no enough data about the relationship between pericardial fat with arrhythmias other than atrial fibrillation or cardiovascular risk scores.ConclusionThe analysis demonstrated that the relationship between pericardial fat volume and cardiovascular diseases was significant. Since pericardial fat is a good predictor of obesity, it suggests investigating its relationship and adds on effect to previously established risk factor to evaluate the possibility of incorporating it with cardiovascular risk scores.
“Enamel layering” using double‐layered enamel‐shade resin composites: The strategy to simulate the optical characteristics of human enamel
Authors: Harnirattisai Choltacha , Kuphasuk Watcharaporn , Ruengrungsom Chirayu , Naorungroj Supawadee , Sattabanasuk Vanthana 
Published: June 2023

AbstractObjectiveTo evaluate the optical match between enamel and resin composites fabricated using mono‐layered and double‐layered techniques.Materials and MethodsEnamel slabs were prepared from human upper incisors and canines. Mono‐layered composite replicas were prepared from seven Filtek Z350XT and Estelite Sigma shades using silicone molds prepared from the respective enamel surfaces. Translucent and enamel shades (A2 or A3) of the two materials were produced from incisor molds for double‐layered replicas, and the groups with the best results underwent accelerated aging. Spectrophotometric evaluation was performed using CIE color system. The differences in translucency (ΔTP) and color (ΔE00) between the enamel and paired composite replicas were calculated and analyzed using parametric statistics (α = 0.05).ResultsFor the mono‐layered composites, white enamel and translucent shades of Filtek yielded the lowest ΔTP for canines (4.6) and incisors (8.9), respectively. The ΔE00 of mono‐layered replicas ranged from 5.1 to 11.8. Double‐layered Filtek replicas displayed a better 1‐day optical match with the lowest ΔTP (3.4–4.0) and ΔE00 (4.2–4.6), irrespective of each layer's thickness.ConclusionsFor canines, the lowest ΔTP of Filtek white enamel was close to the acceptable threshold (4.43). For incisors, the thicker translucent double‐layered Filtek composites demonstrated the greatest optical match before and after aging.Clinical SignificanceUpper incisors and canines have distinct enamel optical properties. Enamel layering using specific double‐layered resin composites could achieve a better optical match with upper incisor enamel.
How sociocultural contexts may shape the impact of the COVID‐19 pandemic on couples' relationships
Authors: Pietromonaco Paula R. , Overall Nickola C. 
Published: June 2023

AbstractThe COVID‐19 pandemic continues to affect couples worldwide who vary in sociocultural values, norms, and expectations, but most work examining connections between pandemic‐related stress and couples' relationships has been conducted in the US or similar Western cultures. Guided by the vulnerability‐stress‐adaptation (VSA) model (Karney & Bradbury, 1995), we present a revised theoretical framework for evaluating how sociocultural contexts may moderate the ways in which pandemic‐related stress risks poor couple functioning or promotes couples' resilience. We briefly describe the theoretical model and associated relationship research in the pandemic context and then evaluate how two illustrative sociocultural contexts (country/culture and race/ethnicity) might impact pandemic‐related external (disease risks and stress exposure) and internal (psychological distress and felt belonging) stress and adaptive relationship functioning. Our review reveals that much remains to be learned about how couples embedded in different sociocultural contexts have adapted over the course of the global pandemic and highlights key areas for future research.
Relationship between gluten availability and celiac disease prevalence: A geo‐epidemiologic systematic review
Authors: Jansson‐Knodell Claire L , Celdir Melis G , Hujoel Isabel A , Lyu Ruishen , Gardinier David , Weekley Kendra , Prokop Larry J , Rubio‐Tapia Alberto 
Published: June 2023

AbstractCeliac disease is a global disease requiring genetic susceptibility and gluten exposure to trigger immune‐mediated enteropathy. The effect of the degree of gluten‐containing grain availability on celiac disease prevalence is unknown. Our objective was to compare country‐based gluten availability to celiac prevalence using a systematic literature review. We searched MEDLINE, Embase, Cochrane, and Scopus until May 2021. We included population‐based serum screening with confirmatory testing (second serological study or small intestine biopsy) and excluded specific, high‐risk, or referral populations. We determined country‐specific gluten availability using the United Nations food balance for wheat, barley, and rye. Human leukocyte antigen (HLA) frequencies were obtained from allelefrequencies.net. The primary outcome was association between gluten‐containing grain availability and celiac disease prevalence. Generalized linear mixed models method with Poisson's link was used for analysis. We identified 5641 articles and included 120 studies on 427 146 subjects from 41 countries. Celiac disease prevalence was 0–3.1%, median 0.75% (interquartile range 0.35, 1.22). Median wheat supply was 246 g/capita/day (interquartile range 214.8, 360.7). The risk ratio (RR) for wheat availability on celiac disease was 1.002 (95% confidence interval [CI]: 1.0001, 1.004, P = 0.036). A protective association was seen with barley, RR 0.973 (95% CI: 0.956, 0.99, P = 0.003), and rye, RR 0.989 (95% CI: 0.982, 0.997, P = 0.006). The RR for gross domestic product on celiac disease prevalence was 1.009 (95% CI: 1.005, 1.014, P < 0.001). The RR for HLA‐DQ2 was 0.982 (95% CI: 0.979, 0.986, P < 0.001), and that for HLA‐DQ8 was 0.957 (95% CI: 0.950, 0.964, P < 0.001). In this geo‐epidemiologic study, gluten‐containing grain availability showed mixed associations with celiac disease prevalence.
Cerebrospinal fluid, brain, and spinal cord levels of L‐aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model
Authors: Errico Francesco , Gilio Luana , Mancini Andrea , Nuzzo Tommaso , Bassi Mario Stampanoni , Bellingacci Laura , Buttari Fabio , Dolcetti Ettore , Bruno Antonio , Galifi Giovanni , Furlan Roberto , Finardi Annamaria , Di Maio Anna , Di Filippo Massimiliano , Centonze Diego , Usiello Alessandro 
Published: June 2023

AbstractThe neuroinflammatory process characterizing multiple sclerosis (MS) is associated with changes in excitatory synaptic transmission and altered central concentrations of the primary excitatory amino acid, L‐glutamate (L‐Glu). Recent findings report that cerebrospinal fluid (CSF) levels of L‐Glu positively correlate with pro‐inflammatory cytokines in MS patients. However, to date, there is no evidence about the relationship between the other primary excitatory amino acid, L‐aspartate (L‐Asp), its derivative D‐enantiomer, D‐aspartate, and the levels of pro‐inflammatory and anti‐inflammatory cytokines in the CSF of MS. In the present study, we measured by HPLC the levels of these amino acids in the cortex, hippocampus, cerebellum, and spinal cord of mice affected by experimental autoimmune encephalomyelitis (EAE). Interestingly, in support of glutamatergic neurotransmission abnormalities in neuroinflammatory conditions, we showed reduced L‐Asp levels in the cortex and spinal cord of EAE mice and increased D‐aspartate/total aspartate ratio within the cerebellum and spinal cord of these animals. Additionally, we found significantly decreased CSF levels of L‐Asp in both relapsing–remitting (n = 157) MS (RR‐MS) and secondary progressive/primary progressive (n = 22) (SP/PP‐MS) patients, compared to control subjects with other neurological diseases (n = 40). Importantly, in RR‐MS patients, L‐Asp levels were correlated with the CSF concentrations of the inflammatory biomarkers G‐CSF, IL‐1ra, MIP‐1β, and Eotaxin, indicating that the central content of this excitatory amino acid, as previously reported for L‐Glu, reflects a neuroinflammatory environment in MS. In keeping with this, we revealed that CSF L‐Asp levels were positively correlated with those of L‐Glu, highlighting the convergent variation of these two excitatory amino acids under inflammatory synaptopathy occurring in MS.image
Is there a relationship between internalized misogyny and premenstrual syndrome and dysmenorrhea in young women? A descriptive‐relational study
Authors: Erenoğlu Rabiye , Sözbir Şengül Yaman , Erenel Ayten Şentürk 
Published: June 2023

AbstractAimThis study utilized a descriptive and relational design to determine the relationship between young women's experiences of premenstrual syndrome (PMS) and dysmenorrhea with internalized misogyny.MethodsA total of 487 individuals were accessed. Data were collected through the “Personal Information Form” prepared by the researchers, the “Functional and Emotional Measure of Dysmenorrhea” the “Premenstrual Syndrome Scale,” and the “Internalized Misogyny Scale.”ResultsThe internalized misogyny scale mean score had significant effects on the functional and emotional measure of dysmenorrhea mean score (p < 0.05). The internalized misogyny scale mean score was found to have a statistically significant effect on the premenstrual syndrome scale (p < 0.05).ConclusionsThis study found that young women's internalized misogyny was highly correlated with PMS and dysmenorrhea, and increased internalized misogyny also increased the severity of PMS and dysmenorrhea in young women.
Somatosensory tinnitus and temporomandibular disorders: A common association
Authors: Didier H. A. , Cappellari A. M. , Sessa F. , Giannì A. B. , Didier A. H. , Pavesi M. M. , Caria M. P. , Curone M. , Tullo V. , Di Berardino F. , Iacona E. , Lilli G. , Barozzi S. , Aldè M. , De Bortoli G. , Zanetti D. , Arnone F. , Bussone G. 
Published: June 2023

AbstractBackgroundAlthough the association between tinnitus and temporo‐mandibular disorders (TMD) has been frequently reported, their rate of association in the literature shows a great variability.ObjectiveWe aimed to investigate the prevalence of TMD in patients with somatosensory tinnitus and, vice versa, the occurrence of somatosensory tinnitus in patients with TMD.MethodsThe study included patients with somatosensory tinnitus (audiological group) and patients with TMD (stomatological group), evaluated at the audiologic and stomatologic clinics of the Policlinic Hospital of Milan, Italy. Common causes of tinnitus, such as hearing and neurological disorders, were excluded. A cervicogenic somatic tinnitus was also ruled out. Different TMD symptoms, including joint noise and joint pain, were considered. The collected data were analysed using descriptive statistical methods, and the Pearson's Chi‐squared test was performed to study the prevalence of the different symptoms by clinical groups.ResultsAudiological group included 47 patients with somatosensory tinnitus. Overall, TMD was diagnosed in 46 patients (97.8%), including TMJ noise in 37 (78.7%), clenching in 41 (87.2%) and pain in 7 (14.8%) patients. Stomatological group included 50 patients with TMD, including joint noise in 32 (64.0%), clenching in 28 (56.0%) and TMJ pain in 42 (84.0%) patients. A somatosensory tinnitus was diagnosed in 12 (24.0%) patients.ConclusionOur study showed a high prevalence of TMD in patients with tinnitus, as well as a not uncommon occurrence of tinnitus in patients presenting with TMD. The distribution of TMD symptoms, such as joint noise, and joint pain was different between the two groups.
Publication performance and trends in bruxism research: A bibliometric analysis
Authors: Al‐Moraissi Essam Ahmed , Ho Yuh‐Shan , Christidis Nikolaos 
Published: June 2023

AbstractBackgroundBruxism is an umbrella term that encompass a multidimensional spectrum of masticatory muscle activities.ObjectiveThe purpose of this study was to do a bibliometric analysis including citation performance in the research topic of bruxism, by using an innovative method including details of article title, author keyword, KeyWords Plus and abstracts.MethodsThe data were retrieved 2022‐12‐19 from the Clarivate Analytics Web of Science Core Collection, and the online version of the Science Citation Index Expanded (SCI‐EXPANDED) for studies published 1992 to 2021. To evaluate research trends, the distribution of keywords in the article title and author‐selected keywords were used.ResultsThe search yielded 3233 documents in SCI‐EXPANDED, of which 2598 were of the document‐type ‘articles’ published in 676 journals. The analysis of the articles revealed that “bruxism/sleep bruxism,” “electromyography,” “temporomandibular disorders” and “masticatory muscles” are the most used keywords by the authors. Further, the most frequently cited study was published 9 years ago and handles the present definition of bruxism.ConclusionThe most productive authors and those with the highest performance have some common features; they have several national and international collaborations; and they have published articles about the definition, aetiology/pathophysiology and prevalence of bruxism, all senior researchers in the field of TMD. Hopefully, based on this study, researchers and clinicians will have information to be stimulated to outline future research projects on bruxism‐related aspects, and to initiate new international or multinational collaborations.
Hypophosphataemia definitions, incidence and associated outcomes in paediatric intensive care: A retrospective cohort study in post‐cardiac surgical patients <2 years of age
Authors: Little Bridget S , Pinto Shalom R , Buckley David , Han Dug Y , Cormack Barbara E 
Published: June 2023

AimHypophosphataemia has been linked to higher morbidity and mortality in intensive care but there is inconsistency in the definition of hypophosphataemia for infants and children. We aimed to determine the incidence of hypophosphataemia in a group of at‐risk children in paediatric intensive care unit (PICU) and associations with patient characteristics and clinical outcomes using three different hypophosphataemia thresholds.MethodsRetrospective cohort study of 205 post‐cardiac surgical patients <2 years of age admitted to Starship Child Health PICU, Auckland, New Zealand. Patient demographics and routine daily biochemistry for 14 days after PICU admission were collected. Rates of sepsis, mortality and length of mechanical ventilation were compared between groups with different serum phosphate concentrations.ResultsOut of 205 children, 6 (3%), 50 (24%) and 159 (78%) had hypophosphataemia at thresholds of <0.7, <1.0 and <1.4 mmol/L, respectively. There were no differences in gestational age at birth, sex, ethnicity or mortality in those with and without hypophosphataemia at any threshold. Children with a serum phosphate <1.4 mmol/L had more mean (SD) total hours of mechanical ventilation (85.2 (79.6) vs. 54.9 (36.2) h, P = 0.02) and those with mean serum phosphate <1.0 mmol/L had more mean hours of mechanical ventilation (119.4 (102.8) vs. 65.2 (54.8) h, P < 0.0001), episodes of sepsis (14% vs. 5%, P = 0.03) and longer length of stay (6.4 (4.8–20.7) vs. 4.9 (3.9–6.8) days, P = 0.02).ConclusionsHypophosphataemia is common in this PICU cohort and serum phosphate <1.0 mmol/L is associated with increased morbidity and length of stay.
Regulation of RIP1‐Mediated necroptosis via necrostatin‐1 in periodontitis
Authors: Tan Liangyu , Chan Weicheng , Zhang Jing , Wang Jiajia , Wang Zizheng , Liu Jie , Li Jiaxin , Liu Xinran , Wang Min , Hao Liang , Yue Yuan 
Published: June 2023

AbstractObjectiveTo explore the mechanism of receptor‐interacting protein 1 (RIP1)‐mediated necroptosis during periodontitis progression.BackgroundRIP3 and mixed lineage kinase domain‐like protein (MLKL) have been detected to be upregulated in periodontitis models. Because RIP1 is involved in necroptosis, it might also play a role in the progression of periodontitis.MethodsAn experimental periodontitis model in BALB/c mice was established by inducing oral bacterial infection. Western blotting and immunofluorescence analyses were used to detect RIP1 expression in the periodontal ligament. Porphyromonas gingivalis was used to stimulate L929 and MC3T3‐E1. RIP1 was inhibited using small‐interfering RNA. Western blotting, reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR), and enzyme‐linked immunosorbent assay (ELISA) analyses were used to detect the effect of necroptosis inhibition on the expression of damage‐associated molecular patterns and inflammatory cytokines. Necrostatin‐1 (Nec‐1) was intraperitoneally injected to inhibit RIP1 expression in mice. Necroptosis activation and inflammatory cytokine expression in periodontal tissue were verified. Tartrate‐resistant acid phosphatase staining was applied to observe osteoclasts in the bone tissues of different groups.ResultsRIP1‐mediated necroptosis was activated in mice with periodontitis. P. gingivalis induced RIP1‐mediated necroptosis in L929 and MC3T3‐E1 cells. After RIP1 inhibition, the expression levels of high mobility group protein B1 (HMGB1) and inflammatory cytokines were downregulated. After inhibiting RIP1 with Nec‐1 in vivo, necroptosis was also inhibited, the expression levels of HMGB1 and inflammatory cytokines were downregulated, and osteoclast counts in the periodontal tissue decreased.ConclusionRIP1‐mediated necroptosis plays a role in the pathological process of periodontitis in mice. Nec‐1 inhibited necroptosis, alleviated inflammation in periodontal tissue, and reduced bone resorption in periodontitis.