bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dispositional authenticity, facilitativeness, femininity ideology, and dyadic relationship functioning in opposite‐gender couples: Actor‐partner interdependence analysis
Authors: Chen Shun , Murphy David , Joseph Stephen 
Published: September 2023

AbstractThis prospective study examined (a) the mediating roles of Carl Rogers' facilitative interpersonal conditions (i.e., genuineness, empathic understanding, and unconditional positive regard) and (b) the moderating roles of femininity ideology in the association between dispositional authenticity and dyadic relationship functioning using a dyadic approach. Participants, 239 opposite‐gender couples, completed the Authenticity Scale, Barrett‐Lennard Relationship Inventory:mini, Femininity Ideology Scale, and Dyadic Adjustment Scale in two separate phases. Longitudinal data were analyzed using the actor‐partner interdependence (mediation/moderation) model within a structural equation modelling framework. Perceived facilitativeness served as a mediator, channelling the positive associations from dispositional authenticity to dyadic relationship functioning, at both interpersonal and intrapersonal levels. Additionally, femininity ideology emerged as a moderator, influencing the relationships between dispositional authenticity and dyadic relationship functioning in both contexts. These findings underscore the significance of embracing authenticity and transcending traditional femininity ideologies for opposite‐gender partners to thrive cohesively as a dyad. The implications of these findings and avenues for future research are further discussed.
Variations in predictors for urinary continence recovery at different time periods following robot‐assisted radical prostatectomy
Authors: Nitta Masahiro , Tazawa Moeko , Takahashi Kumpei , Naruse Jun , Oda Kazuya , Kano Tatsuo , Uchida Takato , Umemoto Tatsuya , Ogawa Takahiro , Kawamura Yoshiaki , Hasegawa Masanori , Shoji Sunao , Miyajima Akira 
Published: September 2023

AbstractIntroductionUrinary dysfunctions are common sequelae following prostatectomy. This study aimed to discover factors that can predict urinary continence recovery at various time periods after robot‐assisted laparoscopic radical prostatectomy (RARP).MethodsThis was a retrospective analysis of data of 419 consecutive patients. Only patients followed up for ≥1 year were enrolled. An answer of “zero pad per day” in the Expanded Prostate Cancer Index Composite urinary assessment (question 5) denoted continence. Possible predictors of urinary continence recovery were evaluated at 3, 3–6, and 6–12 months after the operation.ResultsContinence rates at 3, 6, and 12 months after RARP were 12.9%, 21.2%, and 40.2%, respectively. The proportions of patients using 0–1 pad were 54.2%, 75.7%, and 83.1% at 3, 6, and 12 months after RARP, respectively. Multivariable regression analysis revealed that a membranous urethral length (MUL) ≥11 mm was significantly associated with urinary continence recovery both within 3 months (odds ratio: 0.367, P = .003) and 3–6 months (odds ratio: 0.354, P = .001) after RARP. The analysis also revealed that, in patients with urinary continence at 6 months, a large prostate volume (odds ratio: 1.973, P = .044) and a high body mass index (odds ratio: 2.874, P = .027) were negative predictors of urinary continence recovery within 6–12 months.ConclusionA longer MUL was linked to urinary continence recovery within 6 months following RARP, whereas a large prostate volume and a high body mass index were adverse predictors of urinary continence recovery beyond 6 months.
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition
Authors: Gómez Cristina , Alimajstorovic Zerin , Othonos Nantia , Winter Denise V. , White Sarah , Lavery Gareth G. , Tomlinson Jeremy W. , Sinclair Alexandra J. , Odermatt Alex 
Published: September 2023

AbstractBackground and Purpose11β‐Hydroxysteroid dehydrogenase‐1 (11β‐HSD1) catalyses the oxoreduction of cortisone to cortisol, amplifying levels of active glucocorticoids. It is a pharmaceutical target in metabolic disease and cognitive impairments. 11β‐HSD1 also converts some 7oxo‐steroids to their 7β‐hydroxy forms. A recent study in mice described the ratio of tauroursodeoxycholic acid (TUDCA)/tauro‐7oxolithocholic acid (T7oxoLCA) as a biomarker for decreased 11β‐HSD1 activity. The present study evaluates the equivalent bile acid ratio of glycoursodeoxycholic acid (GUDCA)/glyco‐7oxolithocholic acid (G7oxoLCA) as a biomarker for pharmacological 11β‐HSD1 inhibition in humans and compares it with the currently applied urinary (5α‐tetrahydrocortisol + tetrahydrocortisol)/tetrahydrocortisone ((5αTHF + THF)/THE) ratio.Experimental ApproachBile acid profiles were analysed by ultra‐HPLC tandem‐MS in blood samples from two independent, double‐blind placebo‐controlled clinical studies of the orally administered selective 11β‐HSD1 inhibitor AZD4017. The blood GUDCA/G7oxoLCA ratio was compared with the urinary tetrahydro‐glucocorticoid ratio for ability to detect 11β‐HSD1 inhibition.Key ResultsNo significant alterations were observed in bile acid profiles following 11β‐HSD1 inhibition by AZD4017, except for an increase of the secondary bile acid G7oxoLCA. The enzyme product/substrate ratio GUDCA/G7oxoLCA was found to be more reliable to detect 11β‐HSD1 inhibition than the absolute G7oxoLCA concentration in both cohorts. Comparison of the blood GUDCA/G7oxoLCA ratio with the urinary (5αTHF + THF)/THE ratio revealed that both successfully detect 11β‐HSD1 inhibition.Conclusions and Implications11β‐HSD1 inhibition does not cause major alterations in bile acid homeostasis. The GUDCA/G7oxoLCA ratio represents the first blood biomarker of pharmacological 11β‐HSD1 inhibition and may replace or complement the urinary (5αTHF + THF)/THE ratio biomarker.
Mechanisms of sunitinib resistance in renal cell carcinoma and associated opportunities for therapeutics
Authors: Wang Yunxia , Liu Xiaolin , Gong Luyao , Ding Weihong , Hao Wenjing , Peng Yeheng , Zhang Jun , Cai Weimin , Gao Yuan 
Published: September 2023

AbstractSunitinib is the first‐line drug for renal cell carcinoma (RCC) treatment. However, patients who received sunitinib treatment will ultimately develop drug resistance after 6–15 months, creating a huge obstacle to the current treatment of renal cell carcinoma. Therefore, it is urgent to clarify the mechanisms of sunitinib resistance and develop new strategies to overcome it. In this review, the mechanisms of sunitinib resistance in renal cell carcinoma have been summarized based on five topics: activation of bypass or alternative pathway, inadequate drug accumulation, tumour microenvironment, metabolic reprogramming and epigenetic regulation. Furthermore, present and potential biomarkers, as well as potential treatment strategies for overcoming sunitinib resistance in renal cell carcinoma, are also covered.
Rapid and efficient generation of a transplantable population of functional retinal ganglion cells from fibroblasts
Authors: Xu Zihui , Guo Yanan , Xiang Kangjian , Xiao Dongchang , Xiang Mengqing 
Published: September 2023

AbstractGlaucoma and other optic neuropathies lead to progressive and irreversible vision loss by damaging retinal ganglion cells (RGCs) and their axons. Cell replacement therapy is a potential promising treatment. However, current methods to obtain RGCs have inherent limitations, including time‐consuming procedures, inefficient yields and complex protocols, which hinder their practical application. Here, we have developed a straightforward, rapid and efficient approach for directly inducing RGCs from mouse embryonic fibroblasts (MEFs) using a combination of triple transcription factors (TFs): ASCL1, BRN3B and PAX6 (ABP). We showed that on the 6th day following ABP induction, neurons with molecular characteristics of RGCs were observed, and more than 60% of induced neurons became iRGCs (induced retinal ganglion cells) in the end. Transplanted iRGCs had the ability to survive and appropriately integrate into the RGC layer of mouse retinal explants and N‐methyl‐D‐aspartic acid (NMDA)‐damaged retinas. Moreover, they exhibited electrophysiological properties typical of RGCs, and were able to regrow dendrites and axons and form synaptic connections with host retinal cells. Together, we have established a rapid and efficient approach to acquire functional RGCs for potential cell replacement therapy to treat glaucoma and other optic neuropathies.
The role of boundary objects in collaborative design
Authors: Krakowski Ari , Bishop Lee , Greenwald Eric , Yun Salina 
Published: September 2023

AbstractMuseums and science centers are embracing collaborative design practices to invite diverse expertises into the design process. Co‐construction of museum exhibits and experiences can help museums better engage and affirm local communities as well as facilitate disciplinary and educational research connected to museum experiences. To support more collaborative design processes, many museums are creating new frameworks capable of supporting authentic co‐construction across wells of expertise, both within a museum infrastructure and with external partners. In this perspective, we share insights that have emerged through the development of such a framework at the Lawrence Hall of Science. We position this design framework as a collection of boundary objects (Star & Griesemer, 1989, 387) that can facilitate collaboration, and discuss the affordances of boundary objects for nurturing inclusive participation, knowledge‐sharing, and shared ownership.
Cytopathology of glioneuronal and neuronal tumours with histological correlations
Authors: Lacruz César R. , Álvarez Federico 
Published: September 2023

AbstractGlioneuronal and neuronal tumours constitute a diverse group of tumours that feature neuronal differentiation. In mixed glioneuronal tumours, a glial component is present in addition to the neuronal component. With a few exceptions (eg diffuse leptomeningeal glioneuronal tumour) they are well‐circumscribed and slow‐growing tumours, which is why their prognosis is intrinsically favourable after gross total resection. Rendering an intraoperative diagnosis of glioneuronal/neuronal tumour is therefore important—neurosurgeons should remove them to prevent the persistence of clinical symptoms and/or recurrence. In this context, cytopathological examination can be especially useful for assessing cellular details when frozen section artefacts render poor‐quality preparations, as is the case for this group of tumours, which are frequently mistaken for infiltrating gliomas (eg diffuse astrocytoma infiltrating grey matter, oligodendroglioma) on frozen section slides. The aim of this article is to review the cytomorphological features of glioneuronal and neuronal tumours according to the 2021 World Health Organization classification of central nervous system tumours, 5th edition. Additionally, since interpretation in intraoperative cytology relies on intuiting tissue patterns from cytology preparations, representative histological figures of all discussed entities have been included. Clues for specific diagnoses and the primary diagnostic problems encountered during intraoperative procedures are also discussed.
F‐Wörter und Interventionsinhalte in der Frühförderung nicht gehfähiger Kinder mit Cerebralparese: eine umfangreiche Literaturübersicht
Authors: De Campos Ana Carolina , Hidalgo‐Robles Álvaro , Longo Egmar , Shrader Claire , Paleg Ginny 
Published: September 2023

AbstractZielUntersuchung der Inhalte von Frühfördermaßnahmen für Kleinkinder mit Cerebralparese (CP) mit Gross Motor Function Classification System (GMFCS) Level IV und V und die Identifikation von „F‐Wörtern“, die von den Maßnahmen adressiert werden.MethodeRecherche in vier elektronischen Datenbanken. Einschlusskriterien: experimentelle Originalstudien, die die folgenden PCC‐Komponenten erfüllten: Population: Kleinkinder (im Alter von 0–5 Jahre, mindestens 30% der Stichprobe) mit CP und erheblicher motorischer Beeinträchtigung (GMFCS‐Levels IV oder V, mindestens 30% der Stichprobe); Konzept: nicht‐chirurgische und nicht‐pharmakologische Leistungen der Frühförderung, die Ergebnisse aus einem der Bereiche der Internationalen Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit (ICF) messen; und Kontext: Studien, die zwischen 2001 und 2021 veröffentlicht wurden, in allen Konstellationen und nicht auf einen bestimmten geografischen Ort beschränkt.Ergebnisse87 Studien wurden in dieser Literaturübersicht berücksichtigt, mit qualitativen (n = 3), Mixed Methods (n = 4), quantitativ deskriptiven (n = 22), quantitativ nicht‐randomisierten (n = 39) und quantitativ randomisierten (n = 19) Designs. Die meisten experimentellen Studien befassten sich mit Fitness (n = 59), Familie (n = 46) und Funktion (n = 33), während es nur wenige Studien zu den Bereichen Spaß (n = 6), Freunde (n = 5) und Zukunft (n = 14) gab. Verschiedene Umweltfaktoren (n = 55) waren ebenfalls bedeutsam, z. B. das Angebot an Dienstleistungen, Berufsausbildung, Therapiedosis und Umweltanpassungen.InterpretationViele Studien unterstützen Elternschulungen und den Einsatz assistiver Technologien zur Förderung verschiedener F‐Wörter. Ein „Menü“ von Inhalten der Frühförderung wurden ermittelt, mit Vorschlägen für weitere Forschung, um diese in der klinischen Praxis mit Familien umzusetzen.Was dieser Artikel beiträgt
Familienzentrierte Angebote (einschließlich Beratung von und Intervention durch die Bezugspersonen) und strukturiertes Elterntraining sind wirksame Strategien für Kinder in den GMFCS‐Levels IV und V.
Hilfsmittel (Elektromobilität, unterstütztes Sitzen, Stehen und Gehen) können verschiedene „F‐Wörter“ fördern (Funktion, Fitness, Familie, Spaß, Freunde und Zukunft).
Die geringste Menge an Evidenz wurde für Spaß, Freunde und Zukunft gefunden.
Andere Faktoren (Angebot an Dienstleistungen, Berufsausbildung, Therapiedosis, Umweltanpassungen) sind relevant für Kleinkinder der GMFCS‐Levels IV und V.
Goodbye, Mr. Portugal: Fiscal crisis, constitutional revolution, and the independence of Brazil (1808–22)
Authors: Cariello Rafael , Pereira Thales Zamberlan 
Published: September 2023

AbstractThis article provides a new interpretation of Brazil's independence that relates the process of political emancipation to the Portuguese empire's fiscal crisis at the beginning of the nineteenth century. We discuss the origins and impact of the fiscal crisis that followed the Napoleonic invasion of Portugal in 1807 and the transfer of the government to Rio de Janeiro. Quantitative evidence shows that expenditures with the palace and the army in Brazil were higher than those discussed in the previous literature. Moreover, the government was only able to finance itself by increasing loans via paper money issuances from the Bank of Brazil. Real wages show that the inflationary policy in the 1810s led to a rapid decline in living standards, fuelling dissatisfaction with the government. Our findings are consistent with views expressed in contemporary official correspondence and parliamentary debates.
Emotion socialization profiles in military parents: Associations with post‐traumatic stress disorder
Authors: Giff Sarah T. , Renshaw Keith D. , Denham Susanne A. , Martin Laura N. , Gewirtz Abigail H. 
Published: September 2023

AbstractMilitary families face many difficulties, including a parent deploying to a warzone and the subsequent risk of returning with symptoms of posttraumatic stress disorder (PTSD). Symptoms of PTSD are associated with parenting difficulties; however, little is known about how PTSD symptoms may be associated with emotion socialization (ES), a set of processes crucial to children's emotional well‐being. This project investigated observed ES behaviors in deployed and non‐deployed parents in a sample of 224 predominantly White, non‐Hispanic National Guard/Reserve (NG/R) families with deployed fathers, non‐deployed mothers, and a child between the ages of 4 and 13. Parents completed self‐report questionnaires and families engaged in videotaped parent–child discussions, which were coded for three types of ES behaviors. Latent profile analyses of the coded behaviors identified five profiles of parental ES: Balanced/Supportive, Balanced/Limited Expression, Unsupportive/Distressed, Unsupportive/Positive, and Involved/Emotive/Angry. Multinomial logistic regressions of each parent's profile membership on fathers' PTSD symptoms revealed no significant associations, while additional analyses including additional family factors revealed that greater father PTSD symptoms were associated with a greater likelihood of mothers being in the Balanced/Supportive profile compared to the Balanced/Limited Expression profile, particularly when children displayed average to low levels of emotion during discussion tasks. No other significant associations with PTSD symptoms were detected. Overall, in contrast to the hypotheses, the majority of these findings indicated that PTSD symptoms did not play a significant role in parental ES behaviors.
30 Years of development of English teaching materials: A bibliometric analysis
Authors: Wang Qingru , Ping Wang 
Published: September 2023

AbstractIn recent years, the influence of the development of English teaching materials has attracted the wide attention of international scholars, and a large number of related topic literature has grown exponentially. However, more comprehensive science mapping is needed in this field. This article reviews the development of English teaching materials over 30 years using bibliometric analysis. We extracted the raw data from the Web of Science Core Collection. Specifically, the study examined the following bibliometric indexes: annual scientific production, sources, average citations, authors and affiliations and countries, keywords, research trends, and conceptual structure. Overall, it was found that the research productivity and citations in the field have been increasing during the inclusive years. China, the United States, and the United Kingdom are the top three corresponding authors’ countries. As for the affiliations, the most productive university is Islamic Azad University in Iran. It was also discovered that the most frequent words are English and language, and the trending topics are L2 and English as a foreign language textbooks. Conceptual structure and future directions are also discussed here.
Enfortumab vedotin versus platinum rechallenge in post‐platinum, post‐pembrolizumab advanced urothelial carcinoma: A multicenter propensity score‐matched study
Authors: Taguchi Satoru , Kawai Taketo , Ambe Yoshiki , Kishitani Kenjiro , Sugimoto Kazuma , Miyakawa Jimpei , Nakamura Yu , Noda Michio , Kaneko Tomoyuki , Kamei Jun , Obinata Daisuke , Yamaguchi Kenya , Kakutani Shigenori , Furuya Yoshitsune , Sato Yujiro , Uemura Yukari , Akiyama Yoshiyuki , Yamada Yuta , Sato Yusuke , Yamada Daisuke , Enomoto Yutaka , Nishimatsu Hiroaki , Fujimura Tetsuya , Fukuhara Hiroshi , Nakagawa Tohru , Takahashi Satoru , Kume Haruki 
Published: September 2023

ObjectiveEnfortumab vedotin (EV) was approved for advanced urothelial carcinoma (UC) in 2021 after the EV‐301 trial showed its superiority to non‐platinum‐based chemotherapy as later‐line treatment after platinum‐based chemotherapy and immune checkpoint inhibitors including pembrolizumab. However, no study has compared EV with rechallenging platinum‐based chemotherapy (i.e., “platinum rechallenge”) in that setting.MethodsIn total, 283 patients received pembrolizumab for advanced UC after platinum‐based chemotherapy between 2018 and 2023. Of them, 41 and 25 patients received EV and platinum rechallenge, respectively, as later‐line treatment after pembrolizumab. After excluding two patients with EV without imaging evaluation, we compared oncological outcomes, including progression‐free survival (PFS) and overall survival (OS), between the EV (n = 39) and platinum rechallenge groups (n = 25) using propensity score matching (PSM).ResultsAnalyses on crude data (n = 64) showed no significant differences between the two groups regarding patients' baseline characteristics. PFS (5 months) and OS (11 months) in the EV group were comparable to those (8 and 12 months, respectively) in the platinum rechallenge group. After PSM (n = 36), the baseline characteristics between the two groups became more balanced, and PFS (not reached) and OS (not reached) in the EV group were comparable to those (8 and 11 months, respectively) in the platinum rechallenge group.ConclusionsEV and platinum rechallenge showed equivalent oncological outcomes, even after PSM, and both treatments should therefore be effective treatment options for post‐platinum, post‐pembrolizumab advanced UC.
The silk gland proteome of Stenopsyche angustata provides insights into the underwater silk secretion
Authors: Wang Yu‐Jun , Liu Qing‐Song , Liu Li‐Ping , Zhang Yi‐Chuan , Qiu Shuang , Zhang Wen‐Guang , Lin Jin‐Hang , Qin Yu‐Ting , Wang Xin , Wu Yue‐Ying , Zhao Ping , Xia Qing‐You , Ding Ling , Rong Dong‐Ying , Wang Hong , Dong Zhao‐Ming 
Published: September 2023

AbstractCaddisworms (Trichoptera) spin adhesive silks to construct a variety of underwater composite structures. Many studies have focused on the fibroin heavy chain of caddisworm silk and found that it contains heavy phosphorylation to maintain a stable secondary structure. Besides fibroins, recent studies have also identified some new silk proteins within caddisworm silk. To better understand the silk composition and its secretion process, this study reports the silk gland proteome of a retreat‐building caddisworm, Stenopsyche angustata Martynov (Trichoptera, Stenopsychidae). Using liquid chromatography tandem mass spectrometry (LC‐MS/MS), 2389 proteins were identified in the silk gland of S. angustata, among which 192 were predicted as secreted silk proteins. Twenty‐nine proteins were found to be enriched in the front silk gland, whereas 109 proteins were enriched in the caudal silk gland. The fibroin heavy chain and nine uncharacterized silk proteins were identified as phosphorylated proteins. By analysing the sequence of the fibroin heavy chain, we found that it contains 13 Gly/Thr/Pro‐rich regions, 12 Val/Ser/Arg‐rich regions and a Gly/Arg/Thr‐rich region. Three uncharacterized proteins were identified as sericin‐like proteins due to their larger molecular weights, signal peptides and repetitive motifs rich in serine. This study provides valuable information for further clarifying the secretion and adhesion of underwater caddisworm silk.
How do benefits and challenges influence students’ satisfaction with online education? The mediation effect of awareness
Authors: Chawla Udit , Sondhi Sundeep Singh , Jabbar Meerja Akhil , Mishra Varsha , Singh Harsh Vikram 
Published: September 2023

AbstractTraditional education is shifting towards online instruction, and the temporary closure of educational institutions due to COVID‐19 has prompted its dramatic increase in the last couple of years. With additional benefits, such as flexible schedule, low cost and anywhere learning, online education will determine the near future of education. Due to the increase in Internet reach in India, face‐to‐face instructional methods to which students are habituated to can be substituted. This study aims to analyse students’ satisfaction with the parameters of awareness, challenges and benefits of using new technologies to learn online. With the help of a structured questionnaire and interactions with local inhabitants, the researchers obtained 430 samples from the outskirts of five different cities (Kolkata, Mumbai, Delhi, Chennai and Bengaluru) in India. A conceptual model was built around the constructs of awareness, challenges, benefits and student satisfaction, and their relationship was established and empirically tested. It is found that factors like challenges, benefits and awareness have a significant influence on student satisfaction with online learning. We also find that awareness helps in decreasing the challenges faced and increasing the value of benefits of online education for students.