bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case Series: Gamma Knife Radiosurgery in Brain Arteriovenous, Is It Good Enough?
Authors: Hartanto Yohan Budi , Rory Debora Sharon , Jesisca Jesisca 
Published: August 2023

Highlight:

Brain AVMs are a special concern due to their inherent high risk of bleeding.
Gamma Knife radiosurgery (GKRS), as one of the modality treatments, is intended to induce progressive occlusion of an AVM by using high-dose targeted radiation
The result of Gamma Knife radiosurgery (GKRS) can be full obliteration, with complications because adverse radiation effects.

ABSTRACT
Introduction: Brain arteriovenous malformations (AVMs) are relatively uncommon. Gamma Knife radiosurgery (GKRS) is one of the AVM’s therapeutic interventions, with both advantages and disadvantages. Here, we report the results of two cases of brain AVM after GKRS.
Cases:
Case 1: Non-contrast head MRI imaging of a 45-year-old man with persistent left-sided headaches revealed a 1.4 x 2.5 x 2.28 cm AVM nidus in the left parasagittal frontal lobe. After a single GKRS with a 25-Gy marginal dose, the MRI contrast showed complete obliteration, with persistent perifocal edema and headache.
Case 2: A 25-year-old woman with a history of generalized seizures. The angiograms revealed an AVM nidus with a diameter of 32.58 mm on her right posterior frontal lobe. After a single GKRS with a 22-Gy marginal dose, the MRI contrast showed full obliteration with large edema. The patient had presented with hemiparesis.
Conclusion: In these cases, the results after GKRS were full obliteration with complications of edema, headache, and hemiparesis. We also found that complications appear to be associated with adverse radiation effects.
In Silico Analysis of Pongamia pinnata to Inhibit Neuronal Apoptosis after Ischemic Stroke via NMDAR and Caspase-3
Authors: Shodiq Muhammad Ja'far , Hartono Farmindo , Khaerunnisa Siti , Machin Abdulloh 
Published: August 2023

Highlight:

The potential of Pongamia pinnata as an inhibitor of apoptosis in ischemic stroke has never been evaluated before.
Pongamia pinnata has potential to inhibit neuronal apoptosis via NMDAR and Caspase-3 in ischemic stroke.
Karanjachromene has the best binding interaction to inhibit NMDAR.

ABSTRACT
Introduction: One of the cardiovascular diseases with the highest mortality rate is stroke. Stroke is the second-leading cause of death worldwide. Each year, 12.2 million new cases of stroke occur, of which 7.6 million are ischemic strokes. In ischemic stroke, there are several pathways that cause neuronal apoptosis. The activity of NMDAR and caspase-3 is one of the pathways. Pongamia pinnata phytochemicals have a neuroprotective function against neurological disorders. However, its use as an inhibitor of apoptosis in ischemic stroke has never been evaluated before. Objective: This research was designed to evaluate the phytochemicals of Pongamia pinnata as inhibitors of neuronal apoptosis in ischemic stroke using an in silico study. Methods: This study used four main phytochemicals of Pongamia pinnata, namely Karanjin, Karanjachromene, Pongapin, and Pongachromene. The protein targets for neuronal apoptosis were NMDAR and caspase-3. The molecular docking processes were ligand preparation, protein preparation, grid box determination, molecular docking, and visualized molecular docking. Results: In silico results showed that at NMDAR target proteins, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -5.12, -5.83, -5.03, and -5.13 kcal/mol. At protein targets, Caspase-3, Karanjin, Karanjachromene, Pongapin, and Pongachromene have binding energies of -4.87, -4.98, -4.88, and -5.08 kcal/mol. Conclusion: The phytochemicals of Pongamia pinnata have the potential to inhibit neuronal apoptosis via NMDAR and caspase-3 in ischemic stroke. The binding of Karanjachromene to NMDAR demonstrated the compound's best interaction.
A Rare Case of Dural Tail Sign in the Patient with Glioblastoma Multiforme: A Case Report
Authors: Risdiansyah Risdiansyah , Purwantari Kusuma Eko , Kalanjati Viskasari P , Susilo Rahadian I 
Published: August 2023

Highlight:

A dural tail sign was found in T1W1-MR-images with contrast of a patient with glioblastoma multiforme.
Glioblastoma multiforme as a grade IV malignancy of the astrocytes' glioma, the dura mater can be infiltrated and shown as DTS, although rarely reported.

ABSTRACT
Introduction: The dural tail sign (DTS), which is rarely seen in patients with glioblastoma multiforme (GBM), is reported here. This sign is generally found as a manifestation of meningioma due to the reactive changes of the tumor’s invasion. Case: A 61-year-old Javanese man presented with a gradually worsening headache two months prior to hospital admission. He also suffered from paralysis of his right extremities. His complete blood tests and clinical chemistry were within normal limits. A head CT scan showed a large mass near the convexity of the brain in the left parietal lobe, along with edema and a shift of the midline structures to the right. This was confirmed on the T1W1 MR images with contrast, where DTS was clearly shown. Following surgical resection and tumor excision, histopathology analysis revealed GBM with malignant cell infiltration to the dura in the vicinity of the neoplasm. Conclusion: Here we showed a DTS in GBM as a malignant infiltration marker into the dura
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS ANDROID MENGGUNAKAN SMART APPS CREATOR PADA MATERI BENTUK ALJABAR
Authors: Akbar Muhammad Ilyasin , Ansori Hidayah , Hidayanto Taufiq 
Published: August 2023

Pesatnya perkembangan IPTEKS pada kehidupan sehari-hari berdampak terhadap perkembangannya dalam dunia pendidikan. Perlunya pengembangan media pembelajaran yang sesuai dengan perkembangan teknologi saat ini untuk mempermudah guru dalam melaksanakan proses pembelajaran. Terutama pengembangan media pembelajaran berbasis android pada materi bentuk aljabar karena memberikan kemudahan dalam penyajian materi sehingga mempermudah peserta didik dalam pemahaman konsep bentuk aljabar. Media pembelajaran berbasis android materi bentuk aljabar yang dikembangkan ini dapat diakses pengguna di manapun dan kapanpun. Tujuan penelitian ini ialah menghasilkan media pembelajaran berbasis android pada materi bentuk aljabar yang valid serta mengetahui kepraktisan media pembelajaran berbasis android pada materi bentuk aljabar. Penelitian ini menggunakan metode pengembangan model 4-D dengan penelitian yang dibatasi hanya sampai pada tahap pengembangan (Develop) dengan uji validasi dan uji kepraktisan kepada peserta didik. Validasi dilakukan oleh dua orang validator dan diperoleh 3,47 pada validitas materi dan 3,41 pada nilai validitas media yang keduanya termasuk pada kriteria valid. Sedangkan untuk kepraktisan media pembelajaran berdasarkan angket peserta didik memperoleh rata-rata kepraktisan senilai 81,7% yang termasuk kriteria praktis. Dengan demikian media pembelajaran berbasis android yang dihasilkan termasuk kategori valid dan praktis.
SEQUÊNCIAS DIDÁTICAS SOBRE HISTÓRIAS EM QUADRINHOS: AÇÕES DO PIBID EM UMA ESCOLA ESTADUAL DE PORTO NACIONAL - TO
Authors: Gonçalves dos Santos Luzirene , Capuchinho Adriana Carvalho 
Published: August 2023

O Programa Institucional de Bolsa de Iniciação à Docência (Pibid) atua nas escolas em bairros de vulnerabilidade econômica, contribuindo na trajetória acadêmica, permitindo o contato do graduando com o ambiente escolar já no início do curso, o que ocorreria somente no Estágio Supervisionado. Assim, o medo e a insegurança que envolvem muitos licenciandos, dissipam-se na relação teoria-prática, evitando a evasão e promovendo a formação de docentes comprometidos com uma educação libertadora. Nosso objetivo é demonstrar a importância do Pibid na formação docente e consequentemente no aprimoramento do ensino da rede pública básica, por meio do processo de elaboração e execução de uma sequência didática (DOLZ, NOVERRAZ, SCHNEUWLY, 2004) sobre o gênero textual histórias em quadrinhos, com produção final na temática preconceito racial, a partir da perspectiva dos multiletramentos (KALANTZIS, COPE, PINHEIRO, 2020) e de acordo com a Base Nacional Comum Curricular (BRASIL, 2018) em seis oficinas em uma escola estadual após quase total atividade remota no Pibid 2020-2022. Foi um trabalho desenvolvido por meio de pesquisa-ação com abordagem qualitativa descritiva em que associamos as experiências obtidas nesse processo com os estudos de Libâneo (1999) e Paulo Freire (2004). Os estudantes demonstraram criatividade, criticidade e desenvolvimento linguístico em suas produções.
Palavras-chave: Sequência Didática. Formação Docente. Histórias em Quadrinhos.
A Comparative Analysis of Fasciotomy Results in Children and Adults Affected by Crush-Induced Acute Kidney Injury Following the Kahramanmaras Earthquakes
Authors: Yalın Mustafa , Golgelioglu Fatih 
Published: August 2023

Background and Objectives: The current study aimed to determine the impact of fasciotomy on mortality and morbidity in children and adults with crush-related AKI following the 2023 Kahramanmaraş earthquakes. Materials and Methods: The study included individuals who had suffered crush injuries after the 2023 Kahramanmaraş earthquakes and were identified as having acute kidney injury (AKI). Patients with AKI were divided into two groups based on age: those under 18 years and those over 18 years. A comparative analysis was conducted between the mortality and morbidity rates of patients who underwent fasciotomy and those who did not. Disseminated intravascular coagulopathy (DIC), sepsis, and adult respiratory distress syndrome (ARDS) have all been identified as contributors to morbidity. Results: The study was conducted with a total of 40 patients (21 males and 19 females) aged between four and 83 years. A total of 21 patients underwent fasciotomy and the patients underwent varying numbers of fasciotomy, ranging from zero to 11. The mortality rate was 12.5%, corresponding to five adult patients. No instances of mortality were reported in the paediatric cohort. The application of fasciotomy in instances of crush-induced AKI did not result in elevated levels of mortality in either the paediatric or adult demographic. Within the adult population, a substantial difference in the duration of dialysis was observed between individuals who underwent fasciotomy and those who did not. A statistically significant increase in the number of fasciotomy incisions was observed in patients diagnosed with sepsis compared with those without sepsis. The study found a significant positive correlation between the number of fasciotomy incisions and dialysis days. Conclusions: Neither adult nor paediatric patients with crush-induced AKI showed an increased risk of death after fasciotomy. The number of fasciotomy incisions significantly correlated with the development of sepsis. Despite experiencing delays in hospital admission for paediatric patients, the incidence of both crush syndrome and mortality rates among children remained relatively low.
High Sensitivity for Detection of Primary Diagnostic Variants in Autism, Including De Novo Variants, with Trio Whole Genome Sequencing and Data Reanalysis
Authors: Bar Omri , Vahey Elizabeth , Mintz Mark , Frye Richard E. , Boles Richard G. 
Published: August 2023

Autism spectrum disorder (ASD) is a common condition with lifelong implications and a strong hereditary component suggesting genetic underpinnings. The last decade has seen dramatic improvements in DNA sequencing, bioinformatics, and databases.
We analyzed the raw DNA sequencing files on the Variantyx® (Framingham, MA, USA) bioinformatics platform for the last 50 autism patients evaluated with trio whole genome sequencing (trio-WGS). “Qualified” variants were defined as coding, very rare, and evolutionarily conserved. Primary Diagnostic Variants (PDV) additionally were in genes directly linked to ASD.
A PDV was identified in 34/50 (68%) of cases, including 25 (50%) heterozygous de novo, 3 X-linked, 4 autosomal recessive, 2 autosomal dominant, and 1 heteroplasmic mtDNA variants. De novo variants in genes associated with ASD were far more likely to be Qualified than non-Qualified (control group, P = 0.002), validating that most are indeed disease causal. Only 14/34 (41%) of PDV cases had the variant listed on the laboratory report, and reanalysis increased diagnostic yield from 28% to 68%. The “missed” cases predominately included genes with zero (14 cases) to ≤5 prior reported case reports. Many cases both with and without a PDV had inherited Qualifying variants in known ASD-associated genes, suggesting polygenic inheritance. Thirty-three participants (66%) had treatment recommendation(s) based on DNA analyses.
Our results demonstrate high yield of trio-WGS for revealing molecular diagnoses in ASD that is greatly enhanced by re-analyzing DNA sequencing files. Many are de novo and represent un/under-published conditions.
Electronic Audit (E-Audit), Audit Judgement, Corruption Detection and Audit Quality: BPK RI
Authors: Hakim Luqman , Pardomuan Raymond , Tantri Mitsalina 
Published: August 2023

Research aims: This research is based on the phenomenon that occurred related to the existence of several limitations faced by the Supreme Audit Agency of the Republic of Indonesia in carrying out audits of financial statements in public sector entities. This condition risks affecting audit quality, resulting in the emergence of information gaps between BPK RI, the public and related stakeholders. The purpose of this study was to examine and analyze whether the effect of each independent variable (X1, X2 and X3), including electronic audit (e-audit), audit judgment and the detection of corruption affecting audit quality as the dependent variable (Y ).
Design/Methodology/Approach: The research method used is a quantitative method. This study examines the effect of e-audit, audit judgment and corruption detection on audit quality. This study uses primary and secondary data with a research instrument in the form of a questionnaire. The object of this study is the IB Auditorate as a work unit equivalent to echelon II under the Main Auditorate of State Finance I at the Head Office of the Supreme Audit Agency of the Republic of Indonesia. The number of respondents in this study were 40 auditors/examiners in the IB Auditorate. The type of analysis in this study was statistical descriptive analysis. The statistical analysis tools used are the SPSS and Eviews applications.
Research findings: The results of the empirical study revealed that each of the independent variables (X1, X2, and X3), including e-audit, audit judgment and detection of corruption, had a positive and significant effect on audit quality as the dependent variable (Y).
Theoretical contribution/Originality: Future research is needed to develop with other indicators besides the quality of electronic audit (e-audit), audit judgement, corruption detection and audit quality.
The Influence of Mindfulness and Social Connectedness in Strengthening Job Embeddedness through Sustainable Well-Being as a Mediator Variable at Industrial Estate Area - Bekasi Regency
Authors: Anggraini Ninik , Rahayu Wardani , Yohana Corry 
Published: August 2023

Background: This research aims to identify of Mindfulness, social connectedness and Sustainable Well-Being as intervening variable to strengthen Job Embeddedness
Research Method: This study adopted a quantitative approach and collected data from 197 respondents and used random sampling. In this study the proposed model uses a structural equation model with assisted data processing using Smart-PLS software.

Results and Conclusion: Sustainable well-being is only influenced by mindfulness and social connectedness. Others variable do not have an impact not only on sustainable well-being, but also on job embeddedness. Mindfulness and social connectedness also do not have a direct effect on job embeddedness but are mediated through the role of sustainable well-being.
Be a Good Geoscientist First, and the Rest Will Follow
Authors: Roth B. L. , Hills D. J. 
Published: August 2023

Abstract
This paper seeks to demonstrate the application of learnings from the oil and gas industry, specifically in the field of geoscience, as they relate to applications within the growing industry of Carbon Capture, Utilization and Storage (CCUS). Additionally, this paper will highlight how current educational programs are already geared to produce a talent pipeline for young professionals beginning their careers in the CCUS field or for later career professionals who are looking to transition into CCUS.
To demonstrate the stated objectives, the fundamental theories and knowledge required to operate as a successful geoscientist in the oil and gas industry will be presented. This will include a discussion of basic skills and working knowledge as well as an introduction to various software utilized extensively within the oil and gas industry. This provides context illustrating where the geoscience community has been and the prior focus of many geoscience education pipelines. Then, a comparison of the oil and gas workflows to CCUS workflows will be made to demonstrate that the skills and techniques are aligned.
Example workflows from our experience developing CCUS projects will be presented with a focus on the geologic characterization, such as generating subsurface geologic and structural models and developing reservoir models to predict plume migration. It will be made clear that the fundamentals of these workflows and the skills necessary to implement them are essentially the same. Both oil and gas and CCUS workflows utilize the same basic knowledge and geologic understanding (e.g., reservoir porosity, permeability, volumetrics), the same data (e.g., geophysical well logs, seismic reflection surveys, geologic core analysis) and even the same software. This demonstrates the direct application of knowledge and workflows that were previously gatekept by the oil and gas community and highlights their significance in ability to be applied to new opportunities.
The discussion presented in this paper clearly identifies the overlap of experience gained throughout the detailed history of oil and gas exploration and its direct application to the burgeoning world of CCUS from the perspective of geologic characterization. The examples provided herein also demonstrate that the pipeline for creating new talent already exists with emphasis on learning the fundamentals of geoscience, and the specific application of those skills can be enacted seamlessly within the CCUS community.
Making an Impact: Protecting Guyana's Forests While Growing Energy Production
Authors: Party J. M. , Ocalan S. , Trask A. 
Published: August 2023

Abstract
A framework for evaluation of carbon offsetting strategies is presented depicting the journey of a large independent upstream exploration and production company towards making a first investment in the space. The framework for evaluation included three pillars: foundational and macro research of voluntary carbon markets, corporate intelligence, and project evaluation from a quality and strategic fit approach. Data examined included third party research data, public information from registries and other actors in the voluntary carbon market, and publicly available corporate publications. The information was also put into context against future decarbonization and company values to ultimately arrive at a strategy which was successfully deployed in a first-of-a-kind long-term carbon offset agreement with the Government of Guyana. Key observations made during the process were: 1) nature-based carbon offset projects provide a useful and necessary tool for global decarbonization towards a net-zero 2050 by providing private capital to developing nations, filling a gap from public pledges, while protecting important carbon sinks and ecosystems, 2) for independent E&Ps a strategy to secure offsets from high-quality, geographically-relevant, and large-scale projects appears to be optimal, and 3) demand for credits within the voluntary carbon market are likely to grow and reach around 1 billion tonnes per year by 2030 and potentially greater than 5 billion tonnes per year by 2050, outstripping the supply of high-quality credits. The voluntary carbon market is in its infancy. Excluding European majors, oil and gas companies are in the early stages of participating in the market with limited information published on the topic. This paper will present one approach for entering the market.
CO2 Leak Detection and Conformance Verification Using Borehole Gravity
Authors: Walker K. , Garcia A. Posenato , Nunn J. , Lyman G. 
Published: August 2023

Abstract
Borehole gravity measured from a vertical Carbon Capture and Storage (CCS) injection well, or nearby observation well, provides a cost-efficient solution for monitoring the reservoir for CO2 flow and the overburden for leaks. In this paper, two CO2 injection reservoir models using piston flow and Buckley-Leveret theory are built to simulate and evaluate surface and borehole gravity signatures associated with CO2 flow through thin and thick reservoirs in deep and shallow scenarios. The sensitivity of gravity to plume parameters is also analyzed. The results demonstrate that the lateral gradient in vertical surface gravity after a year of injection is effective for monitoring shallow reservoirs over relatively long time periods and ineffective for deep reservoirs. However, borehole gravity after only a few months of injection is sensitive to both time-lapse density variations and the lateral extent of the saturation plume in all reservoir thickness and depth scenarios. A competition exists for the dominant parameter controlling the borehole gravity signal between density contrast and plume radius. At the bottom of the borehole above the reservoir, sensitivity is dominated by density contrast. As one ascends the borehole, the distance to the reservoir below increases, which lowers the gravity while increasingly adding contributions to the vertical component of gravity, resulting in the plume radius becoming the most sensitive parameter. It is shown that this enhanced sensitivity enables inversions of borehole gravity, using weighted damped least squares, to sufficiently image the radial variation in density contrast associated with the CO2 plume. Analysis of survey parameters on inversion accuracy shows the benefit of conducting surveys that penetrate the reservoir. The results also show that while surface gravity is not capable of seeing small leaks, borehole gravity can detect the depth of leaks within hundreds of feet from a wellbore by a distinctive cross over along the gravity profile. The estimated plume radius based on a reservoir filling model and the comparison of that predicted smooth gravity profile to the observed profile that is sensitive to leak cross-overs in the confining zone provides a cost-effective measurement that can trigger higher cost surveys for deeper levels of investigation.