bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of genetic polymorphism on personalized diet and exercise program for steatotic liver disease
Authors: Akuta Norio , Kawamura Yusuke , Fujiyama Shunichiro , Nakamichi Kenichi , Saegusa Eiji , Ogura Hidetoshi , Kato Masaki , Doi Etsuko , Inoue Naoko , Sezaki Hitomi , Hosaka Tetsuya , Kobayashi Mariko , Saitoh Satoshi , Arase Yasuji , Ikeda Kenji , Suzuki Yoshiyuki , Kumada Hiromitsu , Suzuki Fumitaka 
Published: September 2023

AbstractAimsThe effects of genetic polymorphism on a personalized diet and exercise program for steatotic liver disease (SLD) are still unclear.MethodsParticipants of this retrospective cohort study were 203 Japanese patients with SLD diagnosed by abdominal ultrasonography. All of them were introduced the personalized diet and exercise treatment. A diet of 25–30 kcal/kg multiplied by ideal body weight (BW) daily and aerobic and resistance exercise (exercise intensity of 4–5 metabolic equivalents daily, respectively) were performed for 6 days. Treatment efficacy was evaluated in terms of the rate of decrease of liver function tests, glycolipid metabolism markers, physical findings, image findings, and cardiovascular disease (CVD) risk score at 6 months compared with baseline. Furthermore, the impact of genetic polymorphism was also investigated.ResultsAt 6 months compared with baseline, liver function tests (AST, ALT, γGTP), glycolipid metabolism markers (hemoglobin A1c, triglycerides [TG], low‐density lipoprotein cholesterol), physical findings (BW, body mass index), image finding (liver stiffness measurement), and CVD risk score (Suita score) improved significantly. There was no significant difference in treatment efficacy, except for the rates of decrease of TG, according to genotype PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs6834314. The rates of decrease of TG with TM6SF2 CT were significantly higher than those with CC or TT, and the rates of TG with HSD17B13 AA were significantly higher than those with AG by multiple comparisons.ConclusionPersonalized diet and exercise program for SLD improved liver function tests, physical findings, glycolipid metabolism markers, and CVD risk score. Genetic polymorphism might partially affect treatment efficacy. Further studies should be performed to develop an individualized program for SLD, considering genetic polymorphism.
The role community‐based healthcare providers play in managing hard‐to‐heal wounds
Authors: Beeckman Dimitri , Cooper Matthew , Greenstein Emily , Idensohn Patricia , Klein Robert J. , Kolbig Norbert , LeBlanc Kimberly , Milne Catherine , Treadwell Terry , Weir Dot , White Wendy 
Published: September 2023

AbstractIt is common for community‐based healthcare providers (CHPs)—many of whom have not received specialised training in wound care—to deliver initial and ongoing management for various wound types and diverse populations. Wounds in any setting can rapidly transition to a stalled, hard‐to‐heal wound (HTHW) that is not following a normal healing trajectory. Failure to recognise or address issues that cause delayed healing can lead to increased costs, healthcare utilisation and suffering. To encourage early intervention by CHPs, a panel of wound care experts developed actionable evidence‐based recommendations for CHPs delineating characteristics and appropriate care in identifying and treating HTHWs. A HTHW is a wound that fails to progress towards healing with standard therapy in an orderly and timely manner and should be referred to a qualified wound care provider (QWCP) for advanced assessment and diagnosis if not healed or reduced in size by 40%–50% within 4 weeks. HTHWs occur in patients with multiple comorbidities, and display increases in exudate, infection, devitalised tissue, maceration or pain, or no change in wound size. CHPs can play an important initial role by seeing the individual's HTHW risk, addressing local infection and providing an optimal wound environment. An easy‐to‐follow one‐page table was developed for the CHP to systematically identify, evaluate and treat HTHWs, incorporating a basic toolkit with items easily obtainable in common office/clinic practice settings. A flow chart using visual HTHW clinical cues is also presented to address CHPs with different learning styles. These tools encourage delivery of appropriate early interventions that can improve overall healthcare efficiency and cost.
The island syndrome in birds
Authors: Jezierski Michał T. , Smith William J. , Clegg Sonya M. 
Published: September 2023

AbstractThe island syndrome is a widespread biological phenomenon that describes a suite of morphological, behavioural, demographic and life‐history changes associated with island dwelling. These similar evolutionary responses among disparate groups of animals and plants represent a remarkable case of convergent evolution. Among animals, birds are a highly suitable group to study the island syndrome; they are a comparatively data‐rich taxon, are frequent island colonisers, and sometimes display extreme adaptations such as the loss of flight. However, the avian island syndrome literature is fragmented, and multiple components are rarely considered together even though many are inextricably linked. We reviewed multi‐species comparative studies, single‐species or population‐level studies and anecdotal accounts, to summarise and assess the support for individual components of the island syndrome for birds, and to identify suites of traits that should be considered together. The weight of evidence for island syndrome patterns in morphology is substantial, but is more partial or even anecdotal for various aspects of behaviour, life history and physiology. Full validation of the island syndrome in birds will require the less‐studied components to be treated in a comparative framework, and for covarying components to be examined in an integrated way. An improved description of the scope of the syndrome will pave the way to understanding its drivers.
Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force—Part 2: Specific treatment recommendations
Authors: Seneschal Julien , Speeckaert Reinhart , Taïeb Alain , Wolkerstorfer Albert , Passeron Thierry , Pandya Amit G. , Lim Henry W. , Ezzedine Khaled , Zhou Youwen , Xiang Flora , Thng Steven , Tanemura Atsushi , Suzuki Tamio , Rosmarin David , Rodrigues Michelle , Raboobee Noufal , Pliszewski Georg , Parsad Davinder , Oiso Naoki , Monteiro Paul , Meurant Jean Marie , Maquignon Nicolle , Lui Harvey , Le Poole Caroline , Leone Giovanni , Lee Ai‐Young , Lan Eric , Katayama Ichiro , Huggins Richard , Oh Sang Ho , Harris John E. , Hamzavi Iltefat H. , Gupta Somesh , Grimes Pearl , Goh Boon Kee , Ghia Deepti , Esmat Samia , Eleftheriadou Viktoria , Böhm Markus , Benzekri Laila , Bekkenk Marcel , Bae Jung Min , Alomar Augustin , Abdallah Marwa , Picardo Mauro , van Geel Nanja 
Published: September 2023

AbstractBackgroundThe treatment of vitiligo can be challenging. Up‐to‐date agreed consensus recommendations on the use of topical and systemic therapies to facilitate the clinical management of vitiligo are currently lacking.ObjectivesTo develop internationally agreed‐upon expert‐based recommendations for the treatment of vitiligo.MethodsIn this consensus statement, a consortium of 42 international vitiligo experts and four patient representatives participated in different online and live meetings to develop a consensus management strategy for vitiligo. At least two vitiligo experts summarized the evidence for different topics included in the algorithms. A survey was then given to a core group of eight experts to resolve the remaining issues. Subsequently, the recommendations were finalized and validated based on further input from the entire group during two live meetings.ResultsThe recommendations provided summarize the latest evidence regarding the use of topical therapies (steroids, calcineurin inhibitors and Jak‐inhibitors) and systemic therapies, including steroids and other systemic immunomodulating or antioxidant agents. The different modalities of phototherapies (NB‐UVB, photochemotherapy, excimer devices and home phototherapy), which are often combined with other therapies, are also summarized. Interventional approaches as well as depigmentation strategies are presented for specific indications. Finally, the status of innovative and targeted therapies under development is discussed.ConclusionsThis international consensus statement culminated in expert‐based clinical practice recommendations for the treatment of vitiligo. The development of new therapies is ongoing in vitiligo, and this will likely improve the future management of vitiligo, a disease that still has many unmet needs.
Sexual minority youth in romantic relationships: Associations with youth well‐being
Authors: McCurdy Amy L. , Renley Benton M. , Lavner Justin A. , Meslay Gaëlle , Watson Ryan J. , Russell Stephen T. 
Published: September 2023

AbstractThis study investigated differences in depressive symptoms, loneliness, and self‐esteem for monosexual (lesbian, gay) and plurisexual (bisexual, pansexual, queer) sexual minority youth (SMY) by relationship status (single, partnered) and relationship configuration (same‐gender partner, different‐gender partner). Participants included 338 SMY (Mage = 19.10 years) who reported on their relationship status, partner's gender identity, well‐being, and ability to confide in partner about LGBTQ issues. Results indicated that for plurisexual youth, single status was associated with greater loneliness; plurisexual youth with same‐gender partners reported fewer depressive symptoms and marginally greater ability to confide in their partner about LGBTQ issues than those with different‐gender partners. Findings reveal similarities across SMY while also highlighting some unique challenges among plurisexual youth with different‐gender partners.
How does medical insurance contribution affect corporate value? Evidence from China
Authors: Li Xuchao , Lu Jiankun , Wang Jian , Wang Jiyuan 
Published: September 2023

AbstractUsing medical insurance (MI) to shift employees' health risks outside is an important risk management tool for modern firms. Existing studies usually treat firms' contributions to employees' MI only as a labor cost. However, contributing to MI also has indirect benefits, such as improved labor productivity and R&D innovation, which consequently increase corporate value. This paper studies the impact of firms' MI contributions for employees on corporate value, using social insurance collection system reform in China as a natural experiment. Results show that, first, the reform increases firms' contributions to employees' MI funds. Second, the increase has a positive impact on firms' market‐to‐book ratio. These effects can be explained by enhanced labor productivity, firm efficiency, and innovation. Heterogeneity analysis suggests that the effects are more pronounced for firms in high R&D industries, areas with high pollution, or areas with better medical and labor supplies.
Saint‐Pierre‐le‐Viger (L5‐6) from asteroid 2023 CX1recovered in the Normandy, France—220 years after the historic fall of L'Aigle (L6 breccia) in the neighborhood
Authors: Bischoff Addi , Patzek Markus , Di Rocco Tommaso , Pack Andreas , Stojic Aleksandra , Berndt Jasper , Peters Stefan 
Published: September 2023

AbstractOn February 13, 2023, a huge fireball was visible over Western Europe (fireball event 2023 CX1). After the possible strewn field was calculated, the first of several recovered samples, with a mass of about 100 g, was discovered just 2 days after the fireball event on the ground of the village of Saint‐Pierre‐le‐Viger. Meanwhile, more than 60 samples with a total mass of more than 1 kg were recovered and a piece of one of these is studied here. The fall occurred 220 years after the historic meteorite fall of L'Aigle on April 26, 1803, <120 km south. L'Aigle is the closest meteorite fall to Saint‐Pierre‐le‐Viger and belongs to the same chondrite group. Both meteorites are breccias containing only clasts of high metamorphic degree (type 5 and type 6). Since only 20% of the L chondrites are breccias this coincidence is remarkable. As just mentioned, both samples studied from these rocks in this work are ordinary chondrite breccias and consist of equilibrated and recrystallized lithologies of petrologic type 6. The brecciated texture in L'Aigle, resulting in a remarkable light–dark structure, is more pronounced than the brecciated features in Saint‐Pierre‐le‐Viger, from which also type 5 fragments have been reported. The compositions of low‐Ca pyroxene and olivine grains in Saint‐Pierre‐le‐Viger (Fs21.2and Fa23.4, respectively) clearly require an L‐group classification. L'Aigle was classified as an L6 breccia in the past, and this has now been confirmed by new data on low‐Ca pyroxene and olivine (Fs20.7and Fa23.8, respectively). Saint‐Pierre‐le‐Viger contains local thin shock veins, and both meteorites are moderately shocked. Most olivines in the studied samples have planar fractures, but the estimated abundance of mosaicized olivines of 30%–40% among the large grains require a S4 shock classification. Oxygen isotope and bulk chemical data of Saint‐Pierre‐le‐Viger certainly support the L chondrite classification. Bulk spectral data of Saint‐Pierre‐le‐Viger are dominated by silicate minerals, that is, Fe‐bearing low‐Ca pyroxene, olivine, and plagioclase. Isotopic, chemical, and spectral data of the L'Aigle meteorite are shown for comparison and are very similar, providing additional circumstantial evidence of Saint‐Pierre‐le‐Viger's L chondritic nature.
Light and temperature regulation of leaf morphogenesis in Arabidopsis
Authors: Legris Martina 
Published: September 2023

SummaryLeaves are the main photosynthetic organs in plants, and their anatomy is optimized for light interception and gas exchange. Although each species has a characteristic leaf anatomy, which depends on the genotype, leaves also show a large degree of developmental plasticity. Light and temperature regulate leaf development from primordia differentiation to late stages of blade expansion. While the molecular mechanisms of light and temperature signaling have been mostly studied in seedlings, in the latest years, research has focused on leaf development. Here, I will describe the latest work carried out in the environmental regulation of Arabidopsis leaf development, comparing signaling mechanisms between leaves and seedlings, highlighting the new discoveries, and pointing out the most exciting open questions.
Changes in wax composition but not amount enhance cuticular transpiration
Authors: Grünhofer Paul , Herzig Lena , Zhang Qihui , Vitt Simon , Stöcker Tyll , Malkowsky Yaron , Brügmann Tobias , Fladung Matthias , Schreiber Lukas 
Published: September 2023

AbstractThis study focuses on the role of the qualitative leaf wax composition in modulating the cuticular water loss using a Populus × canescens cer6 mutant line, which accumulates C34–C46 wax ester dimers and is reduced in wax monomers >C24. The two literature‐based hypotheses to be tested were the importance of the amount of wax esters and the weighted mean carbon chain length in restricting cuticular water loss. The main results were acquired by chemical analysis of cuticular wax and gravimetric cuticular transpiration measurements. Besides additional physiological measurements, the leaf surface properties were characterised by scanning electron microscopy and spectrophotometric light reflectance quantification. Mutation of the CER6 gene resulted in striking changes in qualitative wax composition but not quantitative wax amount. Based on the strong accumulation of dimeric wax esters, the relative proportion of esters increased to >90%, and the weighted mean carbon chain length increased by >6 carbon atoms. These qualitative alterations were found to increase the cuticular transpiration of leaves by twofold. Our results do not support the hypotheses that enhanced amounts of wax esters or increased weighted mean carbon chain lengths of waxes lead to reduced cuticular transpiration.
Advice as a model for reasons
Authors: Sneddon Andrew 
Published: September 2023

AbstractSmith (Philosophy and Phenomenological Research, 55, 1995, 109) and Manne (Philosophical Studies, 167, 2014, 89), both following Williams (Making sense of humanity, Cambridge University Press, Cambridge, 1995), have developed advice‐based models of practical reasons. However, advice is not an apt model for reasons. The case for such pessimism is made by examining the positions of Smith and Manne first as attempts to explain the nature of reasons, then as suggestions for reforming our conception of reasons for action. The explanatory projects fail: both views either omit or distort ordinary reasons. The reforming project fails because insufficient reason is provided for thinking that the significant extent of revision offered by these models is worth it. Overall, the advice‐based approach to understanding reasons fails because advising is a social practice to aid with decisions, whereas reasons are considerations that favour action regardless of whether these considerations are inputs to or outputs from such a practice.
Christian epistemology. How faith can shape and promote rationality
Authors: Di Ceglie Roberto 
Published: September 2023

AbstractCan epistemology be shaped by the Christian faith? Is there anything specific to this faith that can give rise to an equally specific epistemology without compromising the autonomy that the latter requires from faith? In the footsteps of Aquinas's religious epistemology, I first focus on the fact that Christian faith seems to characterize intellectual activity in a way that appears to be irreconcilable with epistemological perspectives that are not shaped by faith. Second, I argue that it is possible to do justice to the irreconcilability in question by making reference to what radically distinguishes the Christian faith from the epistemological reflection. Finally, I focus on two ways in which the specific nature of Christian faith can shape and promote rationality, and give rise to a Christian epistemology.
Realizing a blockchain solution without blockchain? Blockchain, solutionism, and trust
Authors: Meyers Gert , Keymolen Esther 
Published: September 2023

AbstractBlockchain is employed as a technology holding a solutionist promise, while at the same time, it is hard for the promissory blockchain applications to become realized. Not only is the blockchain protocol itself not foolproof, but when we move from “blockchain in general” to “blockchain in particular,” we see that new governance structures and ways of collaborating need to be developed to make blockchain applicationswork/becomereal. The qualities ascribed to (blockchain) technologyin abstractoare not to be taken for granted in blockchain applicationsin concreto. The problem of trust, therefore, does not become redundant simply through the employment of “trustless” blockchain technology. Rather, on different levels, new trust relations have to be constituted. In this article, we argue that blockchain is aproductiveforce, even if it does not solve the problem of trust, and sometimes regardless of blockchain technology not implemented after all. The values that underpin this seemingly “trustless technology” such ascontrol,efficiency, andprivacyand the story that is told about these values co‐shape the actions of stakeholders and, to a certain extent, pre‐sort the path of application development. We will illustrate this by presenting a case study on theRed Button(De Rode Knop), a Dutch pilot to develop a blockchain‐based solution that enables people who are in debt to communicate to their creditors that they are, together with the municipality, working on improving their situation, thereby requesting a temporary suspension from debt collection.
Time of day and genotype sensitivity adjust molecular responses to temperature stress in sorghum
Authors: Bonnot Titouan , Somayanda Impa , Jagadish S. V. Krishna , Nagel Dawn H. 
Published: September 2023

SUMMARYSorghum is one of the four major C4 crops that are considered to be tolerant to environmental extremes. Sorghum shows distinct growth responses to temperature stress depending on the sensitivity of the genetic background. About half of the transcripts in sorghum exhibit diurnal rhythmic expressions emphasizing significant coordination with the environment. However, an understanding of how molecular dynamics contribute to genotype‐specific stress responses in the context of the time of day is not known. We examined whether temperature stress and the time of day impact the gene expression dynamics in thermo‐sensitive and thermo‐tolerant sorghum genotypes. We found that time of day is highly influencing the temperature stress responses, which can be explained by the rhythmic expression of most thermo‐responsive genes. This effect is more pronounced in thermo‐tolerant genotypes, suggesting a stronger regulation of gene expression by the time of day and/or by the circadian clock. Genotypic differences were mostly observed on average gene expression levels, which may be responsible for contrasting sensitivities to temperature stress in tolerant versus susceptible sorghum varieties. We also identified groups of genes altered by temperature stress in a time‐of‐day and genotype‐specific manner. These include transcriptional regulators and several members of the Ca2+‐binding EF‐hand protein family. We hypothesize that expression variation of these genes between genotypes along with time‐of‐day independent regulation may contribute to genotype‐specific fine‐tuning of thermo‐responsive pathways. These findings offer a new opportunity to selectively target specific genes in efforts to develop climate‐resilient crops based on their time‐of‐day and genotype variation responses to temperature stress.
Wettability Effects of Curved Superhydrophobic Surfaces on Drag Reduction in Taylor–Couette Flows of Water and Oil
Authors: Alsharief Ahmed F. Alarbi , Duan Xili , Yethiraj Anand , Muzychka Yuri 
Published: September 2023

Abstract
This study examines the effects of surface wettability on the drag-reducing performance of three hydrophobic coatings, namely, flouropel coating (FPC-800M), superhydrophobic binary coating (SHBC), and ultra-ever dry (UED)—when applied to curved aluminum surfaces. The wettability and flow characteristics were characterized using three liquids of different viscosities: de-ionized water and silicone oils of 5 and 10 cSt. Static and dynamic contact angles on the surfaces were measured, and the drag reduction was evaluated using a Taylor–Couette flow cell in a rheometer. The static contact angle (SCA) measurements indicated that the coated surfaces were superhydrophobic for water, with a maximum static contact angle of 158 deg, but oleophilic for the 10 cSt silicone oil, with a static contact angle of 13 deg. The rheometer measurements using water showed a maximum drag reduction of 18% for the UED-coated surfaces. Interestingly, the oleophilic surfaces (which have low SCA) showed a maximum drag reduction of 6% and 7% in the silicone oils. The observed drag reduction is due to an increase in the plastron thickness, which is caused by an increase in the Reynolds number and dynamic pressure coupled with a decrease in the static pressure normal to the superhydrophobic wall.