bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of serological factors in 29 patients with frozen shoulder, a cohort study
Authors: Rouhani Alireza , Parish Masoud , Dashti Mohsen , Hamedfar Hadi , Mahdipour Shahab 
Published: March 2023

Abstract
Background
Frozen Shoulder is a painful and debilitating illness that affects 2 to 5% of the general population and up to 20% of those with diabetes, characterized with significant shoulder pain and reduced mobility, resulting in loss of passive and active movements in all directions in the first stage of frozen shoulder, which is sometimes mistaken with acute and subacute arthritis. We decided to conduct a study to evaluate serological factors in these patients.
Methods
The present investigation was a cohort study. First the target population and sample size were determined and the patients enrolled at the study were asked for their medical history, and then examined by a subspecialist physician to validate the diagnosis of frozen should. For all patients, a series of specific routine blood tests were requested and their shoulder range of motion and scores were recorded.
Results
A total of 29 patients with adhesive capsulitis with a mean age of 55.59 ± 9.57 and a mean BMI of 27.78 ± 4.59 were recruited, of whom 22 were female (75.9%) and 7 were male (24.1%). The mean levels of fasting blood glucose, (FBS) ESR and CRP were 100.61 ± 17.29 mg/dL, 16.89 ± 13.14 mm/h and 2.85 ± 6.88 mg/L, respectively. CRP levels were inversely associated with constant shoulder score (CSS).
Conclusion
The serum level of CRP might be a reliable biomarker for predicting the qualitative state of pain and range of motion in patients with adhesive capsulitis, as it is correlated with CSS.
Trial registration:
The present study was approved by the regional ethics committee of Tabriz University of Medical Sciences based on the Helsinki Declaration with the ethics code IR.TBZMED.REC.1398.990.
On the yield criterion of porous materials by the homogenization approach and Steigmann--Ogden surface model
Authors: Zheng Chenyi , Wang Hongzhen , Jiang Yali , Li Gaohui 
Published: March 2023

Abstract
In this work, we investigate the yield criterion of nanoporous materials by using homogenization approach and Steigmann--Ogden surface model. The representative volume element (RVE) is proposed as an infinite matrix containing a tiny nanovoid. The matrix is incompressible, rigid-perfectly plastic, von Mises materials and nanovoids are dilute and equal in size. First, the constitutive of microscopic stress and microscopic strain rate is established based on the flow criterion. Secondly, according to the Hill's lemma, the relationship between the macroscopic equivalent modulus and the microscopic equivalent modulus is established by homogenization approach. Thirdly, the macroscopic equivalent modulus containing the Steigmann--Ogden surface model including surface parameters, porosity and nanovoid radius is derived from the trial microscopic velocity field. Finally, an implicit macroscopic strength criterion for nanoporous materials is developed. For surface modulus, nanovoids radius and porosity studies are developed through extensive numerical experiments. The research results in this paper have reference significance for the design and manufacture of nanoporous materials.
Effects of timing to surgery on outcomes among adult patients with traumatic expansive intracranial hematomas in a sub-Saharan tertiary hospital: A prospective cohort study
Authors: Kamabu Larrey Kasereka , Bbosa Godfrey S. , Lekuya Hervé Monka , Sekabunga Juliet Nalwanga , Kataka Louange Maha , Obiga Doomwin Oscar Deogratius , Kiryabwire Joel , Galukande Moses 
Published: March 2023

Abstract
Background
Despite the fact that traumatic expansive intracranial hematomas (EIH) are frequent, it is debatable whether the timing of surgery affects the prognosis of patients. The study assessed the effect of timing to surgery on outcomes among adult patients with EIH at Mulago National Referral hospital (MNRH).
Methods
A prospective study was conducted among adult TBI patients with intracranial hematoma during a period of 1 year and follow up for 6 months. Participants were grouped into two arms based on the early (within 24 hours) or late (over 24 hours) surgical evacuation of EIH. The Kaplan–Meier survival curve and log-rank test were used to test for differences in survival status among groups. The level of significance was determined at a p-value of < 0.05.
Results
The analysis covered 324 individuals in all, and 10.2% of them died. Majority of patients (59.6%) had delayed surgery. Patients who underwent early surgery within 24 hours of accident had a median time to mortality of 2 days while those who underwent surgery more than 24 hours had a median time to mortality of 4 days (p=0.004). Patients who underwent early surgery had a median LOS similar to those who had late surgery of 2 days(p=0.278). The overall survival was 46.6%, 95% CI= (17.0 to 71.9). The survival was significantly influenced by QoLIBRI, GOS, SDH, SAH, contusion. Among the survivors, 73.8% were in good functional outcome at discharge. Surgical timing groups were different according to mortality, QoLIBRI at 180 days, which was on average lower in the late surgery group, and complications, which were higher in the same group. Delayed surgery was more associated with posttraumatic seizures (PTS), infection, bleeding, pneumonia, paralysis, nausea, vomiting and decompressive craniectomy.
Conclusion
Early surgery was associated with early mortality, but was neither associated with shorter LOS nor with better survival. Late surgery was associated with lower long-term QoLIBRI, higher complication rate. This study demonstrates that there are still differences in outcome about when to operate. Further high-quality studies are needed to solve this disparity.
Ultra-fast adsorption of radioactive technetium (99mTc) by using mining waste Clay samples, Abu Tartur, Egypt
Authors: Ahmed Ahmed Saleh , Hassan Walaa Ali , Mohamed Mohamed Abdel-Moneim , Ahmed Ezzat Abdalla , Shaalan Nagah , Abukhadra Mostafa Ragab 
Published: March 2023

Abstract
In this study, we have opened a great route to fabricate a high-performance nanocomposite for various functional applications based on the composite of a natural stone. A clay sample (black shale (B.Sh)) was collected from the Abu-Tartur area in Egypt. The black shale was organically modified with organic materials in our laboratory, which is called organic-black shale (O-B.Sh). The samples were characterized by XRD, FTIR, SEM, and XRF. These techniques confirmed that the samples have multi-oxide phases with approximately SiO2 at 54.1%, Al2O3 at 24.73%, Fe2O3 at 6.02%, K2O at 1.12%, MgO at 1.09%, and Na2O of 0.09%, as calculated by XRF. The two samples were applied to the adsorption processes of the radioactive technetium materials, which have been used for the medical treatment of the cancer institute of upper Egypt. The adsorption processes were performed at various concentrations of the radioactive material and various amounts of clay samples. The as-collected B.Sh sample showed an adsorption activity of 65%, however, the organically modified materials showed a high adsorption rate toward technetium reaches to 100% in a very short time, and without any further process. The present collected materials are very promising to withdraw the radioactive materials from the saline solution to save human and environmental health. We believe that these multi-compound composites may open a new approach for creating new fabric composites with high performance toward various applications.
Attraction of Thrips by Salt Forms of Alkyl Nicotinates and Isonicotinates
Authors: Lobur Aleksandr , Ushkova Maria , Todorov Nikolai 
Published: March 2023

Abstract
The methyl and ethyl esters of nicotinic and isonicotinic acids are effective attractants for capturing thrips. The salt forms of nicotinic and isonicotinic acid esters dissociate in air and gradually release the attractant. The use of salt forms of alkyl nicotinates or isonicotinates as thrips attractants has not been previously described. The efficiency of capturing western flower thrips in protected cultivation on cucumber crops and aster flowers by blue sticky traps with dispensers containing salts of hydrochloric, phosphoric, citric, and trifluoroacetic acids with methyl nicotinate was studied. It was found that the use of dispensers with salt forms of methyl nicotinate increased the capture rate of western flower thrips by 1.8 to 2.3 times within a month. Dispensers with citrates of ethyl and methyl ethers of nicotinic and isonicotinic acids increased the capture rate of thrips by 1.7 to 2.2 times.
“Chronic Exposure to Proton Pump Inhibitor use and Diabetes Mellitus Incidence. A Systemic Review and Meta-Analysis “
Authors: CHENCHULA SANTENNA , Sharma PHULEN , Ghanta Mohan Krishna , Amerneni Krishna Chaitanya , Sharma Sushil , Chavan Madhavrao , R Padmavathi , Gupta Rupesh , saggurthi pavani 
Published: March 2023

Abstract
Proton pump inhibitors are very commonly prescribed drugs for gastrointestinal disorders. It is estimated that worldwide a total of 537 million adult populations are affected by diabetes mellitus. The present systematic review was planned to explore an association between PPIs use and the risk of DM occurrence which is unclear yet. We have performed a comprehensive literature search in popular electronic databases such as Pub Med, Embase, Scopus, Cochrane Library and ClinicalTrials.gov using a comprehensive search strategy from inception to December 2022. Quality analysis was assessed using the Newcastle-Ottawa scale system. All Statistical analyses were performed using the “Review Manager 5.4” version. The P value < .05 was set as statistically highly significant. This systematic review identified 12 studies (8: observational; 1: RCT & 3: case-control; n = 11, 64816) with a total of 1, 25,504 cases of diabetes incidence, and the median age ranged from > 18-74.9 years. The pooled RR findings have shown that exposure to PPIs is significantly associated with an increased risk of DM occurrence (RR, 2.44; 95% CI, 1.31–4.54) with high heterogeneity (I2 = 99%, P < 0.00001). A significant relationship between the chronic use of PPIs and the development of diabetes mellitus was found. Hypergastrenemia, gut dysbiosis, hypomagnesaemia, decrease pancreatic secretions, PXR activation, decrease in the levels of insulin-like growth factor-1 and low potency are some of the mechanisms proposed to explain an association of diabetes incidence with chronic PPI use. Furthermore, RCTs on PPIs associated risk of diabetes incidence are suggested
Mechanical effect on implant-supported prosthesis regarding to different loading direction and contact points under static and cyclic loading
Authors: Tak Sangmyeong , Jeong Yuwon , Kim Jong-Eun , Kim Jee-Hwan , Lee Hyeonjong 
Published: March 2023

Abstract
Aims.To evaluate screw loosening and fracture load and angular deviation of a single implant-supported prosthesis under vertical and oblique loading direction and three different loading points at the occlusal surface.
Methods. A total of 40 metal crowns were cemented to internal connection implants and were divided as vertical and oblique loading direction. The occlusal surface of the crown was designed with three flat surfaces, contact A, B, and C, representing outer and inner 20-degree inclination for buccal and lingual cusps. The angular deviations of implant crown under static 50N of loading were measured. And screw removal torque was evaluated before and after 52,500 load cycles. Then, fracture load was measured for each specimen. Data analysis was performed using one-way analysis of variance test of significance followed by Tukey honest significant difference (HSD) test(p<0.05).
Results. Angular deviation results showed statistical significance between all contact points in vertical group compared to oblique group, which showed similar results between contact A and B compared to C. In the other hand, screw loosening evaluation did not show statistical significance among the tested groups. And for the fracture load evaluation the maximum values reached twice the yield values in all contact areas.
Conclusions. Mechanical effects were different regarding to diverse loading direction and contact points. The results of this study suggest that the stress concentration might increase in unfavorable vector direction.
Investigation of the effects of small VCP-interacting protein (SVIP) on the migration and invasion of breast cancer cells.
Authors: Kartal Bahar , Alimogullari Ebru , Çaylı Sevil 
Published: March 2023

Abstract
Background: Endoplasmic reticulum-associated protein degradation (ERAD) eliminates misfolded proteins. Numerous illnesses, including cancer, cystic fibrosis, diabetes, and neurological diseases, are influenced by ERAD. Although there are many proteins involved in ERAD, we focused on small VCP-interacting protein (SVIP).The presence and the function of SVIP in breast cancer types has not been studied yet. The aim of the study was to investigated the expression of SVIP, in breast cancer types and to determine whether SVIP contribute to the migration and invasion of breast cancer cells.
Material and methods: Normal (MCF 10A), estrogen positive (MCF-7) and triple negative (MDA-MB 231) breast cancer cell lines were used in this study. Presence and cellular localization of SVIP in breast cancer cells were examined by immunohistochemistry. Western blot analysis was used to evaluate protein expression after SVIP siRNA transfection of the cells. The consequences of this suppression on cell invasion and migration were identified by using the xCELLigence real-time analysis system (RTAC).
Results: The ımmunoexpression of SVIP was observed in the cytoplasm of MCF 10A, MCF-7, and MDA-MB 231 breast cancer cell lines. The transfection of the cells with SVIP siRNA led to a reduction in the protein expression of SVIP. SVIPsi RNA suppression results in decreased invasion and migration of MCF 10A cells on the other hand increased invasion and migratory potential of MDA-MB 231.
The MCF 7 cell index increased in the invasion setting, although migration was decreased.
Conclusion: We showed that the protein expression and cellular localization of SVIP in normal, estrogen positive and triple negative breast cancer cell lines. The capacity of breast cancer cells to migrate and invade changed when the three cell types were transfected with SVIPsi.
Impact of Timing and Combination of different BNT162b2 and ChAdOx1-S Covid-19 Basic and Booster Vaccinations on Humoral Immunogenicity and Reactogenicity in Adults
Authors: Dedroogh Simon , Schmiedl Sven , Thürmann Petra A. , Graf Katharina , Appelbaum Sebastian , Koß Reinhard , Theis Christian , Zia Zewarudin , Tebbenjohanns Jürgen , Thal Serge C. , Dedroogh Michael 
Published: March 2023

Abstract
In this single-center observational study with 1,206 participants, we prospectively evaluated SARS-CoV-2-antibodies (anti-S RBD) and vaccine-related adverse drug reactions (ADR) after basic and booster immunization with BNT162b2- and ChAdOx1-S-vaccines in four vaccination protocols: Homologous BNT162b2-schedule with second vaccination at either three or six weeks, homologous ChAdOx1-S-vaccination or heterologous ChAdOx1-S/BNT162b2-schedule, each at 12 weeks. All participants received a BNT162b2 booster. Blood samples for anti-S RBD analysis were obtained multiple times over a period of four weeks to six months after basic vaccination, immediately before, and up to three months after booster vaccination. After basic vaccination, the homologous ChAdOx1-S-group showed the lowest anti-S RBD levels over six months, while the heterologous BNT162b2-ChAdOx1-S-group demonstrated the highest anti-S levels, but failed to reach level of significance compared with the homologous BNT162b2-groups. Antibody levels were higher after an extended vaccination interval with BNT162b2. A BNT162b2 booster increased anti-S-levels 11- to 91-fold in all groups, with the homologous ChAdOx1-S-cohort demonstrated the highest increase in antibody levels. No severe or serious ADR were observed. The findings suggest that a heterologous vaccination schedule or prolonged vaccination interval induces robust humoral immunogenicity with good tolerability. Extending the time to boost-immunization is key to both improving antibody induction and reducing ADR rate.
Enhanced Design of Multiplexed Coded Masks for Fresnel Incoherent Correlation Holography
Authors: GOPINATH SHIVASUBRAMANIAN , BLEAHU ANDREI , KAHRO TAUNO , RAJESWARY ARAVIND SIMON JOHN FRANCIS , KUMAR RAVI , KUKLI KAUPO , TAMM AILE , ROSEN JOSEPH , ANAND VIJAYAKUMAR 
Published: March 2023

Abstract
Fresnel incoherent correlation holography (FINCH) is a well-established incoherent digital holography technique. In FINCH, light from an object point splits into two, differently modulated using two diffractive lenses with different focal distances and interfered to form a self-interference hologram. The hologram numerically back propagates to reconstruct the image of the object at different depths. FINCH, in the inline configuration, requires at least three camera shots with different phase shifts between the two interfering beams followed by superposition to obtain a complex hologram that can be used to reconstruct an object’s image without the twin image and bias terms. In general, FINCH is implemented using an active device, such as a spatial light modulator, to display the diffractive lenses. The first version of FINCH used a phase mask generated by random multiplexing of two diffractive lenses, which resulted in high reconstruction noise. Therefore, a polarization multiplexing method was later developed to suppress the reconstruction noise at the expense of some power loss. In this study, a novel computational algorithm based on the Gerchberg-Saxton algorithm (GSA) called transport of amplitude into phase (TAP-GSA) was developed for FINCH to design multiplexed phase masks with high light throughput and low reconstruction noise. The simulation and optical experiments demonstrate a power efficiency improvement of ~ 150% and ~ 200% in the new method in comparison to random multiplexing and polarization multiplexing, respectively. The SNR of the proposed method is better than that of random multiplexing in all tested cases but lower than that of the polarization multiplexing method.
Contribution of the intra-hippocampal orexin system in the regulation of restraint stress response to pain-related behaviors in the formalin test
Authors: Sadeghi Mehdi , Zareie Fatemeh , Gholami Masoumeh , Nazari-Serenjeh Farzaneh , Ghalandari-Shamami Mohadeseh , Haghparast Abbas 
Published: March 2023

Abstract
Stress-induced analgesia (SIA) is due to the activation of several neural pathways and neurotransmitters that often suppress pain perception. Studies have shown that the orexin neuropeptide system is essential in pain modulation. Therefore, this study aims to investigate the role of orexinergic receptors in the hippocampal CA1 region in modulating the SIA response during the formalin test as an animal model of inflammatory pain. Orexin-1 receptor (OX1r) antagonist, SB334867, at 1, 3, 10, and 30 nmol or TCS OX2 29 as orexin-2 receptor (OX2r) antagonist at the same doses were microinjected into the CA1 region in rats. Five minutes later, rats were exposed to restraint stress (RS) for 3 hours, and pain-related behaviors were monitored in 5-min blocks for the 60-min test period in the formalin test. Results showed that applying RS for 3 hours reduced pain responses in the early and late phases of the formalin test. The main findings showed that intra-CA1 injection of orexin receptor antagonists reduced the analgesia caused by stress in both phases of the formalin test. In addition, the contribution of OX1r in mediating the analgesic effect of stress was more prominent than that of OX2r in the early phase of the formalin test. However, in the late phase, both receptors worked similarly. Accordingly, the orexin system and its two receptors in the CA1 region of the hippocampus regulate the SIA response to this animal model of chronic pain.
Sex-specific colonic mitochondrial dysfunction in the indomethacin-induced inflammatory bowel disease model in rats
Authors: Hoang Ngoc , Brooks Karen , Edwards Kristin 
Published: March 2023

Abstract
Introduction: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and encompasses Crohn’s disease and ulcerative colitis. Women appear to have more severe and recurring symptoms of IBD compared to men, most likely due to hormonal fluctuations. Studies have shown that mitochondrial dysfunction plays a role in the development of inflammation and there is evidence of colon mitochondrial alterations in IBD models and patients. In this study we have identified the presence of sex-specific colon mitochondrial dysfunction in a rat model of IBD.
Methods: Eight-week-old male and female rats were treated with indomethacin to induce IBD and mitoTEMPO was administered daily either after or before induction of IBD and until euthanasia. Colons were collected for histology and mitochondrial experiments. Intact mitochondrial respiration, reactive oxygen species (mtROS), the activities of the individual electron transport complexes and the activities of the antioxidant enzymes were measured to assess mitochondrial function.
Results: IBD male rats showed a decrease in citrate synthase activity, cardiolipin levels, catalase activity and an increase in mtROS production. IBD females show a decrease in intact colon mitochondrial respiration, colon mitochondria respiratory control ratio (RCR), complex I activity, complex IV activity, and an increase in mtROS. Interestingly, control females showed a significantly higher rate of complex I and II-driven intact mitochondrial respiration, MCFA oxidation, complex II activity, complex III activity, and complex IV activity compared to control males. The use of a mitochondrial-targeted therapy, mitoTEMPO, improved the disease and colon mitochondrial function in female IBD rats. However, in the males there was no observed improvement, likely due to the decrease in catalase activity.
Conclusions: Our study provides a better understanding of the role mitochondria in the development of IBD and highlights sex differences in colon mitochondrial function. It also opens an avenue for the development of strategies to re-establish normal mitochondrial function that could provide more options for preventive and therapeutic interventions for IBD.