bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Unusual Route of Odontogenic Infection from the Mandible to the Orbit Through the Facial Spaces, Resulting in Blindness: A Rare Case
Authors: Nashawi Faez Ebrahim , Shasho Hamza Omar , Alkheder Ahmad 
Published: March 2023

Abstract
Orbital infection is a rare complication of odontogenic infections, mostly originating from maxillary teeth. In our case, we present one of the unusual routes by which an odontogenic infection of a lower molar tooth has spread into the orbit. A 67-year-old uncontrolled diabetic patient was referred to the ear, nose, and throat department with a complaint of a swollen right masseteric region and orbital infection following a dental procedure on the right mandibular third molar. Computed tomography scan and Magnetic resonance imaging showed multiple abscesses localized in the masseteric and infratemporal spaces and extending into the orbital cavity through a bony erosion in the lateral orbital with no sinus involvement. Improper treatment and poorly controlled diabetes resulted in the extensive spread of the infection. Clinical and radiological re-evaluation has played a major role in the management of our case by elucidating the route of infection and localizing abscess foci accurately, enabling the team to plan the proper surgical intervention. Level of the Clinical Evidence: Level 4
Potential relationships between uveitis and COVID-19: a bioinformatic study based on CEO database
Authors: Li Chen , Chang Jiayu , Lu Peirong 
Published: March 2023

Abstract
Purpose
Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a great impact on human survival and a great threat to public health in countries all over the world. The link between COVID-19 and ocular illness has received increasing attention due to SARS-CoV-2 infection can be transmitted through eye contact. Using bioinformatics methods, we sought to investigate the potential molecular mechanisms between uveitis and COVID-19, providing rationales and directions for further exploration.
Methods
Transcriptomic data of uveitis and COVID-19 patient blood samples were accessed from the Gene Expression Omnibus public database. Common differentially expressed genes were identified. Genetic Ontology analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis, Protein-Protein Interaction network analysis were performed on intersected genes. We screened 5 hub genes by using the maximum clustering centrality algorithm. The Least Absolute Shrinkage and Selection Operator regression analysis identified the potential biomarkers for uveitis and COVID-19. Finally, the expression level and diagnostic value of the biomarker in the two diseases were determined.
Results
50 intersected genes were extracted from differential expression analysis in uveitis and COVID-19. These genes were functionally enriched in cytokine-mediated signaling pathway, vesicle lumen, receptor ligand activity. Through KEGG analysis, these genes were found to be involved in viral protein interaction with cytokine and cytokine receptor, and cytokine-cytokine receptor interaction. HORMAD1 was obtained by Least Absolute Shrinkage and Selection Operator regression analysis, which was high expression in both uveitis and COVID-19 when compared to controls. Receiver Operating Characteristic values and AUC statistics indicated that HORMAD1 had diagnostic value for uveitis and COVID-19.
Conclusions
Bioinformatic analysis predicts HORMAD1 involvement in etiology and therapeutic targets of uveitis and COVID-19. However, additional clinical trials and studies are needed to confirm the role of HORMAD1.
Proficiency Testing Performance in Chemistry Department; a 10-year study of trends in benzoic acid in food
Authors: LI HUI LING 
Published: March 2023

Abstract
Proficiency testing (PT) is considered an indicator to improve competency for laboratory quality management systems. The laboratories participating in PT maintain personnel competency, monitor lab performance, and ensure the validity of the results. The chemistry department started with 20 parameters with participation by its branch laboratories in 1995 and declared it an interlaboratory comparison, then upgraded to PT after applying the procedure following ISO/IEC 17043. Over ten years of results from 2012 to 2021, the chemistry department, which covers the headquarters and 10 branches, achieved satisfactory performance. Only the year 2012 faced an outlier result from the Malacca branch, and two questionable results from the Bintulu and Sibu branches in 2016. Investigation of the outlier and questionable results was based on 4M (Manpower, Method, Machine, and Material). The relationship between the 4M is always mutually beneficial; lacking one will not guarantee high quality. Exploring these 4M provides the lab with a structured framework for root cause analysis by helping the lab understand how each one may have contributed to a particular issue. The trends of PT performance can also be analyzed to increase the quality system. For example, for the Sarawak branch, the Z-score data tends to be over 0, with all the points falling on the upper side, showing that a systematic error occurred. To improve the accuracy of the lab, an investigation is needed. Thus, PT acts as a valuable tool for the laboratory to improve and carry out necessary investigations and corrective actions if any outlier results were obtained in the analysis.
The Effectiveness of Telehealth Gait Retraining in Addition to Standard Physical Therapy Treatment for Overuse Knee Injuries in Soldiers: A Protocol for a Randomized Clinical Trial
Authors: Crowell Michael , Brindle Richard , Miller Erin , Reilly Nicholas , Ford Kevin , Goss Donald 
Published: March 2023

Abstract
Introduction:
Running is the most common cardiovascular exercise in the military. However, there is a high incidence of running-related overuse injuries that reduces military readiness. Gait retraining is a common intervention to treat running-related injuries, but the high cost of equipment and lack of clinician expertise and availability reduces utilization. Gait retraining intervention in a telehealth format might improve feasibility. The purpose of this randomized clinical trial is to determine the effectiveness of a telehealth gait retraining intervention on pain, self-reported function, and biomechanical risk factors for injury in Service Members who present to a Military Health System physical therapy clinic with an overuse knee injury.
Methods
This is a parallel, two-arm, single-blind randomized clinical trial. The two independent variables are intervention (2 levels: telehealth gait retraining intervention with standard of care or only standard of care) and time (3 levels: baseline, 10-weeks or post-intervention, 14-weeks). The primary dependent variables are: 1. worst reported pain during and after running as measured on a visual analog scale; and 2. foot strike pattern during running. Secondary outcomes include worst non-knee pain during running, worst overall knee pain, self-reported function (University of Wisconsin Running Injury and Recovery Index, Single Assessment Numerical Evaluation, Anterior Knee Pain Scale), and running biomechanics (step rate, step length, ground contact time, peak knee adduction angle, peak hip adduction angle, average vertical loading rate, instantaneous vertical loading rate, knee stiffness, and peak rearfoot inversion moment).
Discussion
The effectiveness of a telehealth gait retraining intervention to reduce pain and modify foot strike pattern is not known. The results of this study may help determine the effectiveness and feasibility of a telehealth gait retraining intervention to reduce pain, change foot strike, improve function, and improve running gait biomechanics.
Trial registration:
ClinicalTrials.gov, NCT04269473. Registered 05 February 2020, http://clinicaltrials.gov/NCT04269473.
A Magnetic Resonance Imaging Prediction System based on Deep Neural Network and Radiomics to Predict Microvascular Invasion in Hepatocellular Carcinoma
Authors: Lin Zhao-Yi , Chen Kuang , Chen Wei-Xiang , Li Jin-Feng , Li Cheng-Gang , Song Guo-Quan , Liu Yan-Zhe , Wang Jin , Liu Rong , Hu Ming-Gen 
Published: March 2023

Abstract
Background: A accurate preoperative evaluation of microvascular invasion (MVI) in hepatocellular carcinoma can help surgeons choose the appropriate treatment, while it still remains challenge for radiologists. Computer-aided diagnosis with deep learning technology may be one of the solutions to improve the prediction accuracy.
Methods: MRI with six different sequences were included in this experiment. A deep neural network was used to segment hepatocellular carcinoma after a cross-sequence registration preprocess. Radiomics features together with clinical features were used to form the final prediction model. The clinical features used in the final model was chosen by univariate analysis.
Results: In this work, we collected MRI of 420 cases of hepatocellular carcinomas, in which 140 were MVI cases and 280 patients in the non-MVI group. The radiomics features showed good performances in predicting MVI. The radiomics features showed good performance in predicting MVI. The multi-sequences fusion radiomics features get the best AUC (0.794 ± 0.033). Results for sizes in 3-5cm group showed that the AUC was 0.860±0.065.
Conclusions: A fully automatic system is proposed to predict MVI using preoperative MRI and with the fusion between radiomics and the clinical features, the system shows good performance in prediction MVI, especially in 3-5 cm tumor group.
Bifurcation analysis of a System Modelling Somite Formation
Authors: Kovács Sándor , György Szilvia , Gyúró Noémi 
Published: March 2023

Abstract
This paper deals with stability and bifurcation analysis of a minimal models of vertebrae formation. Conditions are derived under which there can be no change in stability. Using one of the parameters as a bifurcation parameter it is found that various type of bifurcations occurs when the parameter passes through a critical value. Applying the centre manifold theory and the normal form method formulas are given for describing the qualitative properties of the current bifurcation. Computer simulations illustrate the results.
Mathematics Subject Classifications: 92B05 (34D20, 34C23, 34K20).
Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial
Authors: Holzapfel Lindsay , Arnold Cody , Tyson Jon , Shapiro Steven , Reynolds Eric , Pedroza Claudia , Stephens Emily , Kleinfeld Alan , Huber Andrew , Rysavy Matthew , Khan Amir , Lopez Maria del Mar Romero 
Published: March 2023

Abstract

Background: Bilirubin neurotoxicity (BN) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty acids sufficiently to cause bilirubin displacement from albumin, increasing passage of unbound bilirubin (UB) into the brain leading to BN and neurodevelopmental impairment not reliably identifiable in infancy. These risks may be influenced by whether cycled or continuous phototherapy is used to control bilirubin levels.
Objective: To assess differences in wave V latency measured by brainstem auditory evoked responses (BAER) at 34-36 weeks gestational age in infants born ≤750 g or <27 weeks’ gestational age randomized to receive usual or reduced dose lipid emulsion (half of the usual dose) irrespective of whether cycled or continuous phototherapy is administered.
Methods: Pilot factorial randomized controlled trial (RCT) of lipid dosing (usual and reduced) with treatment groups balanced between cycled or continuous phototherapy assignment. Eligible infants are born at ≤750 g or <27 weeks’ gestational age enrolled in the NICHD Neonatal Research Network RCT of cycled or continuous phototherapy. Infants will randomize 1:1 to reduced or usual dose lipid assignment during the first 2 weeks after birth and stratified by phototherapy assignment. Free fatty acids and UB will be measured daily using a novel probe. BAER testing will be performed at 34-36 weeks postmenstrual age or prior to discharge. Blinded neurodevelopmental assessments will be performed at 22-26 months. Intention-to-treat analyses will be performed with generalized linear mixed models with lipid dose and phototherapy assignments as random effects covariates, and assessment for interactions. Bayesian analyses will be performed as a secondary analysis.
Discussion: Pragmatic trials are needed to evaluate whether lipid emulsion dosing modifies the effect of phototherapy on BN. This factorial design presents a unique opportunity to evaluate both therapies and their interaction. This study aims to address basic controversial questions about the relationships between lipid administration, free fatty acids, UB, and BN. Findings suggesting a reduced lipid dose can diminish the risk of BN would support the need for a large multicenter RCT of reduced versus usual lipid dosing.
Trial Registration: Clinical Trials.gov, NCT04584983, Registered 14 October 2020, https://clinicaltrials.gov/ct2/show/NCT04584983
Protocol Version: Version 3.2 (10/5/2022)
Clinical characteristics and outcomes of hypersensitivity pneumonitis in South Korea
Authors: Zo Sungmin , Chung Man Pyo , Yoo Hak young , Lee Kyung Soo , Han Joungho , Chung Myung Jin , Yoo Hongseok 
Published: March 2023

Abstract
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) that results from an immune-mediated reaction involving various antigens in susceptible individuals. However, the clinical characteristics and outcomes of HP in South Korea are not well understood. This retrospective study analyzed 43 patients with pathologically proven HP at a single tertiary hospital in Korea between 1996 and 2020. In addition, case reports of HP published in Korea were collected. The clinical characteristics, etiologies, treatment, and outcomes of patients from our center, as well as case reports, were reviewed. Patients from our hospital were divided into fibrotic and nonfibrotic subtypes according to the ATS/JRS/ALAT guidelines. Among 43 patients with biopsy-proven HP, 12 (27.9%) and 31 (72.1%) patients were classified into the fibrotic and nonfibrotic subtypes, respectively. The fibrotic HP group was older (64.6 ± 8.5 vs. 55.2 ± 8.3, p = 0.002) with less frequent complaints of fever (0% vs. 45.2%, p = 0.013) compared to the nonfibrotic HP group. The most common inciting antigen was household mold (21, 48.8%), followed by inorganic substances (6, 14.0%). Inciting antigens were not identified in eight (18.6%) patients. Treatment of corticosteroid was initiated in 34 (79.1%) patients. An analysis of 46 patients from Korea by literature review demonstrated that reported cases were relatively younger and drugs were the most common etiology compared to our cohort. The analysis of reported cases, as well as our cohort, showed that exposure history and clinical manifestations are heterogeneous for patients with HP in South Korea.
Sacubitril/Valsartan can improve the cardiac function in heart failure patients with a history of cancer: A real-world retrospective study about aged population
Authors: Chen Zhulu , Zhang Chuan , Zhu Yuxi , Gao Diansa , Mao Min , Zuo Zhong 
Published: March 2023

Abstract
Amis
Sacubitril/Valsartan is now becoming the class one recommendation for HFrEF. Some studies have shown the positive effect of Sacubitril/Valsartan on HFrEF cancer patients, while there is devoid of evidence about the effect of this drug in aged cancer patients with HFmrEF and HFpEF. We did this retrospective study to investigate the beneficial effect of Sacubitril/Valsartan on all three kinds of HF patients with cancer in the aged population.
Method and results
By searching the patients with a diagnosis of both cancer and heart failure over 65, the patients who had received treatment with Sacubitril/Valsartan were selected as the candidates for Sacubitril/Valsartan group, and the patients who had received conventional HF therapy without Sacubitril/Valsartan were chosen as the control group. Data were collected for up to 9 months. We filtered 38 patients and 50 patients valid for Sacubitril/Valsartan group and control group, respectively. After initiation of heart failure management, our study found a better cardiac condition in Sacubitril/Valsartan group, having better LVEF, LVFS, NT-proBNP in 3rd, 6th, 9th month (P<0.05) and better NYHA function classification after the treatment. We also observed fewer cases of deterioration on LAD (p=0.029) and LVEDD (p=0.023) in Sacubitril/Valsartan group. In subgroup analysis, our study showed that all three kinds of HF patients had better LVEF, LVFS, and NT-proBNP in Sacubitril/Valsartan group (P<0.05).
Conclusion
Our study further indicated that Sacubitril/Valsartan can improve cardiac function and benefit cardiac remolding in aged cancer patients of all three kinds of HF. As we know, this is the first study to provide new evidence for the use of Sacubitril/Valsartan in aged cancer patients of all three kinds of HF.
Paraburkholderia phytofirmans PsJN colonization of rice endosphere triggers an atypical transcriptomic response compared to rice native Burkholderia s.l. endophytes
Authors: King Eoghan , Wallner Adrian , Guigard Ludivine , Rimbault Isabelle , Parrinello Hugues , Klonowska Agnieszka , Moulin Lionel , Czernic Pierre 
Published: March 2023

Abstract
Plant microbiome recently emerged as a reservoir to develop sustainable alternatives to chemical fertilizers and pesticides. However, the response of plants to beneficial microbes appears as a critical issue to understand the molecular bases of the interaction of plants with their microbiota. In this study, we combined root colonization, phenotypic and transcriptomic analyses to decipher the commonalities and specificities of the response of rice to closely related Burkholderia s.l. endophytes. In general, these findings suggest that a rice non-native Burkholderia s.l. strain, Paraburkholderia phytofirmans PsJN, is able to colonize the root endosphere while triggering a markedly dissimilar response compared to rice-native Burkholderia s.l. strains. This shows the variability of the response of plants to microbes from different hosts of origin. The most staggering finding from the investigation was that a much more conserved response to the three endophytes used in this study is triggered in leaves compared to roots. Additionally, the transcriptional regulations of genes related to secondary metabolism, immunity and phytohormones appears as markers of the strain-specific responses. Future studies must investigate if these findings can be extrapolated to other models of plants and beneficial microbes to further advance the potential of microbiome-based solutions for crop production.
Understanding needs and expectations to start effective communities of practice
Authors: Elbrink Sanne H , Elmer Shandell L , Osborne Richard H 
Published: March 2023

Abstract
Background
Communities of practice (CoPs) are frequently used in health settings to enhance knowledge and support action around public health issues. Yet, most are ineffective and often at risk of not delivering on this promise. To prevent the loss of time and resources by organisations, facilitators, and members, this paper argues for a reliable assessment of the needs of people who intend to join and to set realistic expectations to assure effective communities of practice. This research proposes a valid and reliable needs assessment and analysis tool for starting communities of practice, by presenting the results of using such a tool.
Methods
Inception needs assessments were developed, tested and administered to 246 respondents entering five communities of practice that focused on one of three public health issues: health literacy, mental health literacy and trauma-informed care. One community of practice had a global audience, four were based in Australia. Data from the needs assessments were analysed qualitatively and supplemented with descriptive statistics. Results were used to develop an analysis tool to support future communities of practice.
Results
The short-term expectations of respondents included seeking to increase their knowledge and getting to know other members of the community of practice. Long-term expectations shifted towards undertaking action, collaborating and improving health outcomes. While respondents learning expectations included a wide range of topics, they articulated very specific knowledge they expected to share with others. There were high expectations of receiving practical support from the facilitator and a strong preference for meetings with synchronous interaction. Most respondents who planned to join focused initially on the direct and individual benefits and participation they expected from others, whereas they indicated limited intention to actively contribute to the learning needs of other community members. Respondents appeared to need to take time to build self-confidence and trust, and frequently applied a wait-and-see attitude.
Conclusions
The findings of this study suggest that an inception needs assessment allows members to express their needs and expectations, which directly informs the direction and structure of a community of practice, gives voice to members, and supports facilitators in managing expectations.
Evaluation of Hospital Indicators Before and After the Implementation of an Orthogeriatric Unit in Older People with Hip Fracture: 5 Years of Follow-Up
Authors: Sánchez Brenda Lorena Pillajo , Ortega María José Suing , Torre Patricio Gabriel Buendía Gómez de la 
Published: March 2023

Abstract
Background: In the older population, hip fracture (HF) is considered a serious public health problem worldwide since it increases morbidity and mortality.
Objective: analyze hospital indicators of care, sociodemographic, clinical and geriatric variables, before and after the implementation of the Orthogeriatric Unit for older adults with acute phase hip fracture at the Hospital de la Policia No. 1 Quito (HPNQ1).
Materials and methods: observational, retrospective, analytical and single-center study completed during the period between January 1, 2012 to December 21, 2017. The sample was a non-probabilistic sample, with 77 participants of 65 years or older admitted with a diagnosis of HF. Information was obtained from the clinical history with confidentiality measures in the handling of information accordingly with the principles of bioethics
Results: mean age of participants was 82.51 (SD= 8.51, range 65 – 99), with a ratio of 1.85 females per 1 male. Osteoporosis and polypharmacy were significantly associated with HF. Prior to the creation of the Orthogeriatric Unit, the hospital indicators showed that the average stay was 11 days and after the implementation of the unit this was reduced to an average of only 8 days, and costs decreased by 30% ($13588.22 vs $ 9814.04 before and after the implementation of an Orthogeriatric unit, respectively).
Conclusion: the orthogeriatric unit substantially improves hospital indicators, reduces total hospital stay by 50% and costs by 30%.