bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial photodynamic and photobiomodulation adjuvant therapies for medication-related osteonecrosis of the jaw – Report of two cases with long-term follow-up
Authors: Paiva Angela B. P. , Pereira Beatriz C. , Brozoski Mariana A. , Araújo Julia G. L. , Deboni Maria Cristina Zindel 
Published: September 2023

Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare condition with high morbidity. In this study, we report the management of two recalcitrant cases of MRONJ in the mandibles of two older women who received treatment with alendronate for osteoporosis. Sequestrectomies, combined with antimicrobial photodynamic therapy (aPDT) and photobiomodulation (PBMT), were performed in both patients. During perioperative and weekly postoperative aPDT sessions, a diode laser treated three anatomical points by emitting a continuous gallium-aluminum-arsenide wave at 660 nm (red laser), 0.028 cm2, 0.1 W, 3.57 W/cm2 for 90 s per point, 9 J per point, 321 J/cm2, and a total energy of 27 J. PBMT was applied weekly after surgery at 808 nm wavelength (other parameters being equal) for wound healing and pain relief. Both patients were followed-up for two years without any report of recurrence. Thus, aPDT and PBMT can be considered non-invasive adjuvant therapies for MRONJ without any adverse effects.
“At Sea, At Odds, Astray, Adrift” : Linguistic Destabilization in Jhumpa Lahiri’s Self-Translated Novel Whereabouts
Authors: Wanner Adrian 
Published: September 2023

Abstract
This article compares the Italian original of Jhumpa Lahiri’s novel Dove mi trovo (2018) with the English self-translation, which was published in 2021 under the title Whereabouts. Lahiri claims that her embrace of Italian was a means to escape the alienation caused by her bilingual upbringing in Bengali and English. Paradoxically, this quest for wholeness was coupled with insecurity in Italian, a language in which Lahiri only achieved fluency in middle age. Self-translation puts this linguistic ambiguity to a new stress test. In the confrontation between Lahiri’s Italian-language and Anglophone selves, her English becomes affected by Italian calques, creating a hybridized language mirroring the author’s own hybrid linguistic consciousness.
Seasonal Variability of Near-Inertial/Semidiurnal Fluctuations and Turbulence in the Subarctic North Atlantic
Authors: Kunze Eric , Lien Ren-Chieh , Whalen Caitlin B. , Girton James B. , Ma Barry , Buijsman Maarten C. 
Published: September 2023

Abstract
Six profiling floats measured water-mass properties (T, S), horizontal velocities (u, υ), and microstructure thermal-variance dissipation rates χT in the upper ∼1 km of the Iceland and Irminger Basins in the eastern subpolar North Atlantic from June 2019 to April 2021. The floats drifted into slope boundary currents to travel counterclockwise around the basins. Pairs of velocity profiles half an inertial period apart were collected every 7–14 days. These half-inertial-period pairs are separated into subinertial eddy (sum) and inertial/semidiurnal (difference) motions. Eddy flow speeds are ∼O(0.1) m s−1 in the upper 400 m, diminishing to ∼O(0.01) m s−1 by ∼800-m depth. In late summer through early spring, near-inertial motions are energized in the surface layer and permanent pycnocline to at least 800-m depth almost simultaneously (within the 14-day temporal resolution), suggesting rapid transformation of large-horizontal-scale surface-layer inertial oscillations into near-inertial internal waves with high vertical group velocities through interactions with eddy vorticity gradients (effective β). During the same period, internal-wave vertical shear variance was 2–5 times canonical midlatitude magnitudes and dominantly clockwise-with-depth (downward energy propagation). In late spring and early summer, shear levels are comparable to canonical midlatitude values and dominantly counterclockwise-with-depth (upward energy propagation), particularly over major topographic ridges. Turbulent diapycnal diffusivities K ∼ O(10−4) m2 s−1 are an order of magnitude larger than canonical midlatitude values. Depth-averaged (10–1000 m) diffusivities exhibit factor-of-3 month-by-month variability with minima in early August.
Active versus expectant management for premature rupture of membranes at term: A randomized, controlled study
Authors: Awkadigwe Fredrick I. , Ezugwu Frank O. , Eleje George U. , Nweze Sylvester O. , Odugu Boniface U. , Dinwoke Victor O. , Olu Ephraim A. , Ortuanya Kelvin E. , Ezenwaeze Malachy N. , Eze Obiechina C. , Onyekpa Johnson I. , Ofor Ifeanyichukwu J. , Onah Osmond O. , Omeje Chimdalu U. , Ezike Andre U. , Enyinna Perpetua K. , Malachy Divinefavour E. , Okafor Chigozie G. 
Published: September 2023

Objective To compare the effects on feto-maternal outcomes of expectant versus active management for premature rupture of membranes (PROM) at term. Methods This was a prospective randomized (1:1) controlled study involving 86 pregnant-women who received either expectant management (n = 43) or active management with misoprostol (n = 43) for PROM at term. Primary outcome was route of delivery. Secondary outcomes were: PROM to presentation interval; latency period; PROM to delivery interval; recruitment to delivery interval; labour and delivery complications. Results Baseline-characteristics were similar between groups. There was no significant difference between active and expectant groups in mean PROM to presentation/admission, or PROM to delivery. However, mean latency period (11.1 ± 7.3 hours vs 8.8 ± 5.5 hours) and mean recruitment to delivery intervals after PROM (14.7 ± 5.2 hours vs 11.8 ± 5.0 hours) were significantly shorter for the active group compared with the expectant group. Although the rate of caesarean section was less in expectant management group (21%) compared with the active management group (30%), the difference was not statistically significant. There were no significant differences between groups in delivery or perinatal complications. Conclusion Active and expectant management for PROM at term gave comparable outcomes in terms of methods of delivery and complications. However, active management significantly shortened the latency period and induction to delivery intervals compared with expectant management. Trial-Registration: Pan-African-trial-registry-(PACTR)-approval-number PACTR202206797734088
Impact of recycled polypropylene on the specific properties of stretched polypropylene tapes for woven bag
Authors: Daoudi Hamza , Semlali Fatima-Zahra , Kassab Zineb , Ablouh El-Houssaine , Bouhfid Rachid , Qaiss Abou El Kacem , El Achaby Mounir 
Published: September 2023

To create woven bag packaging for Nitrogen-Phosphorus-Potassium (NPK) fertilizer granules, this work conducted an experimental study on the utilization of recycled polypropylene (RPP) in stretched polypropylene (PP) tapes. By altering the amount of RPP using an industrial-scale stretching tapes extrusion technique, the as-obtained RPP granules were utilized to develop three stretched tape composite series filled with 0.9, 2.8, and 3.6 wt% of RPP, respectively. The series of produced composites were described in terms of their structural, rheological, mechanical, and thermal characteristics. It was found that the inclusion of RPP into PP stretched tape composites improved the composites’ rigidity but reduced their toughness, due to the cumulative legacy effect of calcite particles and the RPP oxidative effect from the reprocessing history. However, RPP has shown good results in terms of storage modulus and strain at break, hence can be utilized in textile and engineering applications.
Evaluation of proteinuria monitoring practice patterns and treatment implications in patients with cancer receiving bevacizumab products
Authors: Sturgill Kuan , Dicke Katie , Zangardi Mark , Osborne Kara 
Published: September 2023

Introduction Proteinuria is a well-known toxicity of bevacizumab which can lead to kidney injury or nephrotic syndrome. There is little guidance on the frequency of monitoring and management of those that experience bevacizumab-induced proteinuria. Previous literature has suggested routine monitoring with every dose has limited clinical significance. Currently, there is no standardization of proteinuria monitoring at OhioHealth. Methods This retrospective descriptive study included 100 adult patients who received at least 3 doses of a bevacizumab product for a malignant condition at any OhioHealth facility from April 15, 2022 to October 15, 2022. The primary outcome was to describe the average number of proteinuria tests ordered over the course of therapy. Results Of the 100 patients evaluated, 91 received proteinuria monitoring during treatment with bevacizumab. The overall average number of tests completed per patient per month based on treatment period of bevacizumab was 1.51. Twenty-two of 91 patients (24%) developed grade 2+ proteinuria. Average time to first grade 2+ proteinuria event was 5.7 months. A history of baseline renal dysfunction or chronic kidney disease was the only predefined factor found to be significantly associated with developing grade 2+ proteinuria. The most common treatment modification following a grade 2+ proteinuria result was a delay in therapy. Conclusion Proteinuria monitoring may not be necessary for short definitive courses of bevacizumab and closer monitoring should be considered in patients with baseline renal dysfunction or CKD. Future direction includes evaluating the cost of varying proteinuria tests and developing a recommendation for OhioHealth to standardize testing.
Dimensionless study of the fiber arrangement on particle filtration characteristics in a multi-fiber filter
Authors: Fan Jianhua , Yang Kun , Zhang Liang , Wang Lu , Han Zhiwu 
Published: September 2023

In this paper, two-dimensional numerical simulations are performed to investigate the particle filtration performance of multi-fiber filters using computational fluid dynamics ( CFD) technology. We combine fluid and particle properties as well as fiber size into single dimensionless numbers to analyze the influence of fiber arrangements on the system pressure drop and capture efficiency during the filtration process. The results indicate that the motion and deposition of aerosol particles significantly depend on the combined effects of Brownian diffusion, interception and inertial impaction mechanisms. The capture of aerosol particles with diameters less than 0.1 [Formula: see text] is strongly determined by the Brownian diffusion mechanism. For the case where interception and inertia impaction mechanisms dominate, particles with diameters in the range of 1–10 [Formula: see text] are more easily captured. In addition, the filter with a staggered fiber array structure exhibits a higher capture efficiency than that of parallel and random cases. From the quality factor standpoint, filters with both the staggered and random fiber arrangements show a better filtration performance. The research results can provide a fundamental understanding of the particle filtration process and the theoretical basis for filter design and optimization.
Epidemiology of adult hand injuries presenting to a tertiary hand surgery unit: a review of 4216 cases
Authors: Kankam Hadyn K. N. , Ibrahim Hussein , Liew Mei Sien , Hauff Ellie , Tullie Sebastian , Parthiban Sunil , Chester Darren L. 
Published: September 2023

This study investigates the pattern of hand injuries presenting to a UK regional tertiary centre. All referrals to our Hand Surgery Unit in 2019 were reviewed. Subgroup analyses of sex, deprivation, occupational injuries and assault cases were carried out. Over the study period, 4216 cases were referred. Most were male (70%), with a median age of 36 years and from a deprived area (75.2%). Soft tissue injury was documented in 53.6% and bone injury (fracture/dislocation) in 52.4%. Surgical management was required in 2214 (52.5%) cases. Work-related injuries accounted for 16.7% of cases and were more likely to require surgery. Assault-related injuries accounted for 8% of cases, with a male preponderance. Our findings can help facilitate service provision and guide regional and national prevention policies. Level of evidence: III
Minasgeraisite-(Y) discredited as an ordered intermediate between datolite and hingganite-(Y)
Authors: Atencio Daniel 
Published: September 2023

AbstractMinasgeraisite-(Y) is discredited on the basis of it being an ordered intermediate between datolite and hingganite-(Y) (IMA-CNMNC Proposal 23-F). An idealised formula is (Ca2Y2)□2(Be2B2)Si4O16(OH)4, which corresponds to Ca2□B2Si2O8(OH)2 (datolite) + Y2□Be2Si2O8(OH)2 (hingganite-(Y)). The type material is rich in Bi, the Bi-richest portion yet discovered from the type locality is shown to be an intermediate member between datolite, hingganite-(Y) and a hypothetical end-member phase yet to be found of composition Bi2□Be2Si2O8(OH)2. Minasgeraisite-(Y) has a different space group to datolite and hingganite-(Y). This lowering of symmetry to an acentric triclinic system is caused by different element occupancies on the A site of the gadolinite supergroup structure, which for minasgeraisite-(Y) becomes four individual sites. Such an order–disorder of elements is not considered as species-defining criteria despite the change in space group. Therefore, minasgeraisite-(Y) is discredited.
UGCG modulates heart hypertrophy through B4GalT5-mediated mitochondrial oxidative stress and the ERK signaling pathway
Authors: Cui Shengyu , Zhang Xutao , Li Yuhua , Hu Shan , Wu Bing , Fang Zhao , Gao Jixian , Li Ming , Wu Haoliang , Tao Bo , Xia Hao , Xu Lin 
Published: September 2023

AbstractMechanical pressure overload and other stimuli often contribute to heart hypertrophy, a significant factor in the induction of heart failure. The UDP-glucose ceramide glycosyltransferase (UGCG) enzyme plays a crucial role in the metabolism of sphingolipids through the production of glucosylceramide. However, its role in heart hypertrophy remains unknown. In this study, UGCG was induced in response to pressure overload in vivo and phenylephrine stimulation in vitro. Additionally, UGCG downregulation ameliorated cardiomyocyte hypertrophy, improved cardiomyocyte mitochondrial oxidative stress, and reduced the ERK signaling pathway. Conversely, UGCG overexpression in cardiomyocytes promoted heart hypertrophy development, aggravated mitochondrial oxidative stress, and stimulated ERK signaling. Furthermore, the interaction between beta-1,4-galactosyltransferase 5 (B4GalT5), which catalyses the synthesis of lactosylceramide, and UGCG was identified, which also functions as a synergistic molecule of UGCG. Notably, limiting the expression of B4GalT5 impaired the capacity of UGCG to promote myocardial hypertrophy, suggesting that B4GalT5 acts as an intermediary for UGCG. Overall, this study highlights the potential of UGCG as a modulator of heart hypertrophy, rendering it a potential target for combating heart hypertrophy.
The effect of serum origin on cytokines induced killer cell expansion and function
Authors: Jabbarpour Zahra , Aghayan Seyed Sajjad , Moradzadeh Kobra , Ghaffari Sasan , Ahmadbeigi Naser 
Published: September 2023

Abstract
Background
Cytokine-induced killer (CIK) cells have shown promising results in adoptive immunotherapy. However, serum may play a determining role in the large-scale expansion of these cells for clinical applications. According to Good Manufacturing Practice (GMP) guidelines to reduce the use of animal products in cell-based therapies; therefore, this study sought to investigate the impact of serum origin and the reduced serum concentration on the pattern of cell expansion and function.

Methods
Peripheral blood mononuclear cells (PBMCs) isolated from a healthy donor were expanded based on the CIK cell expansion protocol. The cell culture medium was supplemented with three types of sera comprising fetal bovine serum (FBS), human serum (HS), or human-derived platelet lysate (hPL) at different concentrations (10%, 5%, and 2.5%). The proliferation kinetics for each group were investigated for 30 days of cell culture.

Results
Cell proliferation in 10% concentration of all sera (hPL, FBS, HS) was higher than their lower concentrations. Moreover, hPL was significantly associated with higher expansion rates than FBS and HS in all three concentrations. Furthermore, cells cultured in hPL showed higher viability, cytotoxicity effect, and CIK CD markers expression.

Conclusion
hPL at a concentration of 10% showed the best effect on CIK cell proliferation and function.
Incidence and influencing factors of acute gastrointestinal injury after cardiac surgery
Authors: Lu Ruolin , Yang Biwen 
Published: September 2023

Abstract
Background
To investigate the incidence and influencing factors of acute gastrointestinal injury (AGI) after cardiac surgery.

Methods
A total of 346 cases receiving treatment in the Intensive Care Unit (ICU) of the Department of Cardiovascular Surgery in our hospital from January 2021 to December 2021 were enrolled and their basic information was collected, including age, gender, height, weight, past medical history, Nutrition Risk Screening 2002, Body Mass Index (BMI), total operation duration, stay in ICU, preoperative blood routine examination results, complete biochemical examination, diamine oxidase (DAO) on Day 1, D-lactic acid index, a postoperative gastrointestinal condition, other postoperative complications and death during hospitalization. Moreover, logistic regression analysis was performed to identify the independent risk factors influencing the incidence of AGI after cardiac surgery.

Results
The incidence and mortality of AGI after cardiac surgery were 10.40% (36/346) and 25% (9/36), respectively. A dichotomous logistic regression multivariate analysis revealed that DAO on Day 1 (odd ratio = 1.062, p = 0.006) and stay in ICU (odd ratio = 1.192, p < 0.001) were independent risk factors of AGI after cardiac surgery, and total protein is a protective factor (odd ratio = 0.914, p = 0.012).

Conclusions
Factors influencing AGI after cardiac surgery have been determined in this study. Our data suggest that patients with AGI after cardiac surgery have a decreased preoperative total protein, and elevated DAO on Day 1. Total protein and DAO on Day 1 were found to be correlated with AGI.
A systematic review of the clinical impact of small colony variants in patients with cystic fibrosis
Authors: Ryan Harrigan , Ballard Emma , Stockwell Rebecca E. , Duplancic Christine , Thomson Rachel M. , Smith Kimberley , Bell Scott C. 
Published: September 2023

Abstract
Background
Cystic fibrosis (CF) is a life-limiting disorder that is characterised by respiratory tract inflammation that is mediated by a range of microbial pathogens. Small colony variants (SCVs) of common respiratory pathogens are being increasingly recognised in CF. The aim of this systematic review is to investigate the prevalence of SCVs, clinical characteristics and health outcomes for patients with CF, and laboratory diagnostic features of SCVs compared to non-small colony variants (NCVs) for a range of Gram-positive and Gram-negative respiratory pathogens.

Methods
A literature search was conducted (PubMed, Web of Science, Embase and Scopus) in April 2020 to identify articles of interest. Data pertaining to demographic characteristics of participants, diagnostic criteria of SCVs, SCV prevalence and impact on lung function were extracted from included studies for analysis.

Results
Twenty-five of 673 studies were included in the systematic review. Individuals infected with SCVs of Staphylococcus aureus (S. aureus) were more likely to have had prior use of the broad-spectrum antibiotic trimethoprim sulfamethoxazole (p < 0.001), and the prevalence of SCVs in patients infected with S. aureus was estimated to be 19.3% (95% CI: 13.5% to 25.9%). Additionally, patients infected with SCVs of Gram-negative and Gram-positive pathogens were identified to have a lower forced expiratory volume in one second percentage predicted (-16.8, 95% CI: -23.2 to -10.4) than those infected by NCVs. Gram-positive SCVs were commonly described as small and non-haemolytic, grown on Mannitol salt or blood agar for 24 h at 35°C and confirmed using tube coagulase testing.

Conclusion
The findings of this systematic review demonstrate that SCVs of S. aureus have a high prevalence in the CF community, and that the occurrence of SCVs in Gram-positive and Gram-negative pathogens is linked to poorer respiratory function. Further investigation is necessary to determine the effect of infection by SCVs on the CF population.
Venous thromboembolic prophylaxis: current practice of surgeons in Australia and New Zealand for major abdominal surgery
Authors: Lott Natalie , Senanayake Tharindu , Carroll Rosemary , Gani Jon , Smith Stephen R 
Published: September 2023

Abstract
Background
Surgical prophylaxis for venous thrombo-embolic disease (VTE) includes risk assessment, chemical prophylaxis and mechanical prophylaxis (graduated compression stockings [GCS] and/or intermittent pneumatic compression devices [IPCD]). Although there is overwhelming evidence for the need and efficacy of VTE prophylaxis in patients at risk, only about a third of those who are at risk of VTE receive appropriate prophylaxis.

Objective
There is debate as to the best combination of VTE prophylaxis following abdominal surgery due to lack of evidence. The aim of this survey was to understand this gap between knowledge and practice.

Methods
In 2019 and 2020, a survey was conducted to investigate the current practice of venous thromboembolism (VTE) prophylaxis for major abdominal surgery, with a focus on colorectal resections. The study received ethics approval and involved distributing an 11-item questionnaire to members of two professional surgical societies: the Colorectal Surgical Society of Australia and New Zealand (CSSANZ) and the General Surgeons Australia (GSA).

Results
From 214 surgeons: 100% use chemical prophylaxis, 68% do not use a risk assessment tool, 27% do not vary practice according to patient risk factors while > 90% use all three forms of VTE prophylaxis at some stage of treatment. Most surgeons do not vary practice between laparoscopic and open colectomy/major abdominal surgery and only 33% prescribe post-discharge chemical prophylaxis. 42% of surgeons surveyed had equipoise for a clinical trial on the use of IPCDs and the vast majority (> 95%) feel that IPCDs should provide at least a 2% improvement in VTE event rate in order to justify their routine use.

Conclusion
Most surgeons in Australia and New Zealand do not use risk assessment tools and use all three forms of prophylaxis regardless. Therfore there is a gap between practice and VTE prophylaxis for the use of mechanical prophylaxis options. Further research is required to determine whether dual modality mechanical prophylaxis is incrementally efficacious. Trial Registration- Not Applicable.