bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer
Authors: Gopikrishnan Mohanraj , R Hephzibah Cathryn , R Gnanasambandan , Ashour Hossam M. , Pintus Gianfranco , Hammad Mohamed , Kashyap Manoj Kumar , C George Priya Doss , Zayed Hatem 
Published: May 2023

Abstract
Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a significant mortality rate and is one of the most common malignancies in women. CircRNAs have been demonstrated to contribute to the pathogenesis of breast cancer including its initiation, progression, metastasis, and resistance to drugs. By acting as miRNA sponges, circRNAs can indirectly influence gene expression by disrupting miRNA regulation of their target genes, ultimately altering the course of cancer development and progression. Additionally, circRNAs can interact with proteins and modulate their functions including signaling pathways involved in the initiation and development of cancer. Recently, circRNAs can encode peptides that play a role in the pathophysiology of breast cancer and other diseases and their potential as diagnostic biomarkers and therapeutic targets for various cancers including breast cancer. CircRNAs possess biomarkers that differentiate, such as stability, specificity, and sensitivity, and can be detected in several biological specimens such as blood, saliva, and urine. Moreover, circRNAs play an important role in various cellular processes including cell proliferation, differentiation, and apoptosis, all of which are integral factors in the development and progression of cancer. This review synthesizes the functions of circRNAs in breast cancer, scrutinizing their contributions to the onset and evolution of the disease through their interactions with exosomes and cancer-related intracellular pathways. It also delves into the potential use of circRNA as a biomarker and therapeutic target against breast cancer. It discusses various databases and online tools that offer crucial circRNA information and regulatory networks. Lastly, the challenges and prospects of utilizing circRNAs in clinical settings associated with breast cancer are explored.
Double-stranded RNA (dsRNA) technology to control forest insect pests and fungal pathogens: challenges and opportunities
Authors: Singewar Kiran , Fladung Matthias 
Published: May 2023

AbstractClimate change alters the seasonal synchronization between plants and respective pests plus pathogens. The geographical infiltration helps to shift their hosts, resulting in novel outbreaks that damage forests and ecology. Traditional management schemes are unable to control such outbreaks, therefore unconventional and competitive governance is needed to manage forest pests and pathogens. RNA interference (RNAi) mediated double-stranded RNA (dsRNA) treatment method can be implemented to protect forest trees. Exogenous dsRNA triggers the RNAi-mediated gene silencing of a vital gene, and suspends protein production, resulting in the death of targeted pathogens and pests. The dsRNA treatment method is successful for many crop insects and fungi, however, studies of dsRNA against forest pests and pathogens are depleting. Pesticides and fungicides based on dsRNA could be used to combat pathogens that caused outbreaks in different parts of the world. Although the dsRNA has proved its potential, the crucial dilemma and risks including species-specific gene selection, and dsRNA delivery methods cannot be overlooked. Here, we summarized the major fungi pathogens and insect pests that have caused outbreaks, their genomic information, and studies on dsRNA fungi-and pesticides. Current challenges and opportunities in dsRNA target decision, delivery using nanoparticles, direct applications, and a new method using mycorrhiza for forest tree protection are discussed. The importance of affordable next-generation sequencing to minimize the impact on non-target species is discussed. We suggest that collaborative research among forest genomics and pathology institutes could develop necessary dsRNA strategies to protect forest tree species.
Study on the activation of cell death mechanisms: in search of new therapeutic targets in glioblastoma multiforme
Authors: Gaiaschi Ludovica , Favaron Cristina , Casali Claudio , Gola Federica , De Luca Fabrizio , Ravera Mauro , Roda Elisa , Rossi Paola , Bottone Maria Grazia 
Published: May 2023

AbstractMalignant primary brain tumors remain among the most difficult cancers to treat, in particular, Glioblastoma Multiforme (GBM) is the deadliest brain tumor. The standard therapies currently used are not efficient enough in improving patients’ survival and quality of life. Cisplatin (CDDP), a platinum-based drug, has shown efficacy against different solid neoplasms, but it is also associated to different forms of off-target toxicity. To overcome the limitation in the use of CDDP in the treatment of GBM patients, fourth generation platinum compounds are been synthesized, one of them is the Pt(IV)Ac-POA, a prodrug with a medium-chain fatty acid as axial ligand, which acts as a histone 3 deacetylase inhibitor. Moreover, recently, the antioxidant effects of medicinal mushrooms have been shown to induce a lowering of the toxicity of chemotherapy drugs, inducing greater therapeutic efficiency, thus the combined therapy of chemotherapy and micotherapy could be helpful in the treatment of GBM reducing the adverse effects of the former thanks to phytotherapy’s antioxidant, anti-inflammatory, immunomodulatory and antitumoral activities. Here, through immunoblotting, ultrastructural and immunofluorescence analysis, we evaluated the contribution in the activation of different cell death pathway of Micotherapy U-Care, a medicinal blend supplement, used together with platinum-based compounds on human glioblastoma U251 cells.
Agreement of wall shear stress distribution between two core laboratories using three-dimensional quantitative coronary angiography
Authors: Kageyama Shigetaka , Tufaro Vincenzo , Torii Ryo , Karamasis Grigoris V. , Rakhit Roby D. , Poon Eric K. W. , Aben Jean-Paul , Baumbach Andreas , Serruys Patrick W. , Onuma Yoshinobu , Bourantas Christos V. 
Published: May 2023

AbstractWall shear stress (WSS) estimated in models reconstructed from intravascular imaging and 3-dimensional-quantitative coronary angiography (3D-QCA) data provides important prognostic information and enables identification of high-risk lesions. However, these analyses are time-consuming and require expertise, limiting WSS adoption in clinical practice. Recently, a novel software has been developed for real-time computation of time-averaged WSS (TAWSS) and multidirectional WSS distribution. This study aims to examine its inter-corelab reproducibility. Sixty lesions (20 coronary bifurcations) with a borderline negative fractional flow reserve were processed using the CAAS Workstation WSS prototype to estimate WSS and multi-directional WSS values. Analysis was performed by two corelabs and their estimations for the WSS in 3 mm segments across each reconstructed vessel was extracted and compared. In total 700 segments (256 located in bifurcated vessels) were included in the analysis. A high intra-class correlation was noted for all the 3D-QCA and TAWSS metrics between the estimations of the two corelabs irrespective of the presence (range: 0.90–0.92) or absence (range: 0.89–0.90) of a coronary bifurcation, while the ICC was good-moderate for the multidirectional WSS (range: 0.72–0.86). Lesion level analysis demonstrated a high agreement of the two corelabls for detecting lesions exposed to an unfavourable haemodynamic environment (WSS > 8.24 Pa, κ = 0.77) that had a high-risk morphology (area stenosis > 61.3%, κ = 0.71) and were prone to progress and cause events. The CAAS Workstation WSS enables reproducible 3D-QCA reconstruction and computation of WSS metrics. Further research is needed to explore its value in detecting high-risk lesions.
Tail-dependence, exceedance sets, and metric embeddings
Authors: Janßen Anja , Neblung Sebastian , Stoev Stilian 
Published: May 2023

AbstractThere are many ways of measuring and modeling tail-dependence in random vectors: from the general framework of multivariate regular variation and the flexible class of max-stable vectors down to simple and concise summary measures like the matrix of bivariate tail-dependence coefficients. This paper starts by providing a review of existing results from a unifying perspective, which highlights connections between extreme value theory and the theory of cuts and metrics. Our approach leads to some new findings in both areas with some applications to current topics in risk management.We begin by using the framework of multivariate regular variation to show that extremal coefficients, or equivalently, the higher-order tail-dependence coefficients of a random vector can simply be understood in terms of random exceedance sets, which allows us to extend the notion of Bernoulli compatibility. In the special but important case of bivariate tail-dependence, we establish a correspondence between tail-dependence matrices and $$L^1$$

L
1

- and $$\ell _1$$

ℓ
1

-embeddable finite metric spaces via the spectral distance, which is a metric on the space of jointly 1-Fréchet random variables. Namely, the coefficients of the cut-decomposition of the spectral distance and of the Tawn-Molchanov max-stable model realizing the corresponding bivariate extremal dependence coincide. We show that line metrics are rigid and if the spectral distance corresponds to a line metric, the higher order tail-dependence is determined by the bivariate tail-dependence matrix.Finally, the correspondence between $$\ell _1$$

ℓ
1

-embeddable metric spaces and tail-dependence matrices allows us to revisit the realizability problem, i.e. checking whether a given matrix is a valid tail-dependence matrix. We confirm a conjecture of Shyamalkumar and Tao (2020) that this problem is NP-complete.
An unlikely bifurcation: history of sustainable (but not Green) chemistry
Authors: Krasnodębski Marcin 
Published: May 2023

AbstractThe concept of green chemistry dominated the imagination of environmentally-minded chemists over the last thirty years. The conceptual frameworks laid by the American Environmental Protection Agency scholars in the 1990s constitute today the core of a line of thinking aimed at transforming chemistry into a sustainable science. And yet, in the shadow of green chemistry, a broader, even if less popular, concept of sustainable chemistry started taking shape. Initially, it was either loosely associated with green chemistry or left undefined as a distinct but generaly different approach. In such a vague form, it was endorsed by the organizations such as OECD and the IUPAC in the late 1990s. It was not until the 2010s however, when it solidified as a separate more embracing and more overarching tradition that could compete with green chemistry by offering insights that the latter lacked. Sustainable chemistry seeks to transcend the narrow focus on chemical synthesis and embrace a much more holistic view of chemical activities including social responsibility and sustainable business models. Due to an interesting historical coincidence, it was in Germany where sustainable chemistry took roots and became institutionalized for the first time. It was thanks to German exceptionalism and the unwillingness of German scholars to embrace the “green” terminology originating from the US, the concept of sustainable chemistry could safely mature and develop in the German-speaking world, before reaching a high degree of formalization with dedicated journals, founding articles, and programmatic principles aspiring to transform the entire chemical enterprise in the years to come.
Hydrogeological Properties of Till Amended with Green Liquor Dregs (GLD): Recycling of an Industrial Residue for Reclamation of Acid Generating Mine Sites
Authors: Nigéus Susanne , Maurice Christian , Lindblom Jenny 
Published: May 2023

AbstractThe oxidation of sulfide minerals in mine wastes is a possible threat to the environment as it might have potential to generate acid rock drainage (ARD). A common method to reduce ARD is to apply a dry cover on the mine waste deposit. Considering the massive amounts of mine waste produced in Sweden (104-million-ton in year 2018) there is a great need for suitable dry cover materials. Using non-hazardous industrial residues in the dry cover would be beneficial for both the mining industry and the providing industry as stricter waste management legislation incentivizes them to develop their waste management strategies. The objective of this study was to investigate if an addition of Green Liquor Dregs (GLD), a residue from pulp production, can decrease the hydraulic conductivity and increase the water retention capacity (WRC) of three different tills, with the purpose of improving the performance of a dry cover material on a mine waste deposit. Another objective was to investigate how the hydraulic conductivity and WRC are affected by the contents of fines and clays in the tills. The study concludes that the water retention capacity of the tills improves with GLD addition, however, the hydraulic conductivity did not decrease enough to reach the in Sweden required < 10−8 m/s. Even though, GLD could still successfully be used in the reclamation of mine sites as the high WRC can be seen as the most important factor in deterring acid rock drainage by keeping the sealing layer close to saturation. This study further indicates that there are other factors than the particle size distribution of the materials that controls the hydraulic conductivity of the mixtures, such as initial water content, dry density, and compaction effort.
A Formal Theory of Choreographic Programming
Authors: Cruz-Filipe Luís , Montesi Fabrizio , Peressotti Marco 
Published: May 2023

AbstractChoreographic programming is a paradigm for writing coordination plans for distributed systems from a global point of view, from which correct-by-construction decentralised implementations can be generated automatically. Theory of choreographies typically includes a number of complex results that are proved by structural induction. The high number of cases and the subtle details in some of these proofs has led to important errors being found in published works. In this work, we formalise the theory of a choreographic programming language in Coq. Our development includes the basic properties of this language, a proof of its Turing completeness, a compilation procedure to a process language, and an operational characterisation of the correctness of this procedure. Our formalisation experience illustrates the benefits of using a theorem prover: we get both an additional degree of confidence from the mechanised proof, and a significant simplification of the underlying theory. Our results offer a foundation for the future formal development of choreographic languages.
Continuous perioperative heart rate variability monitoring in video-assisted thoracoscopic surgery lobectomy—a pilot study
Authors: Frandsen Mikkel Nicklas , Huang Lin , Petersen René Horsleben , Foss Nicolai Bang , Mehlsen Jesper , Kehlet Henrik 
Published: May 2023

AbstractHeart rate variability (HRV) is a measure of cardiac autonomic modulation and is potentially related to hypotension, postoperative atrial fibrillation, and orthostatic intolerance. However, there is a lack of knowledge on which specific time points and indices to measure. To improve future study design, there is a need for procedure-specific studies in an enhanced recovery after surgery (ERAS) video-assisted thoracic surgery (VATS) lobectomy setting, and for continuous measurement of perioperative HRV. HRV was measured continuously from 2 days before until 9 days after VATS lobectomy in 28 patients. After VATS lobectomy, with median length of stay = 4 days, the standard deviation between normal-to-normal beats and the total power of HRV were reduced for 8 days during the night and day times, while low-to-high frequency variation and detrended fluctuation analysis were stable. This is the first detailed study to show that HRV measures of total variability were reduced following ERAS VATS lobectomy, while other measures were more stable. Further, preoperative HRV measures showed circadian variation. The patch was well tolerated among participants, but actions should be taken to ensure proper mounting of the measuring device. These results demonstrate a valid design platform for future HRV studies in relation to postoperative outcomes.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia
Authors: Jadhav Satyawan B. , Amore Benny M. , Bockbrader Howard , Crass Ryan L. , Chapel Sunny , Sasiela William J. , Emery Maurice G. 
Published: May 2023

AbstractPopulation pharmacokinetics (popPK) of bempedoic acid and the popPK/pharmacodynamic (popPK/PD) relationship between bempedoic acid concentrations and serum low-density lipoprotein cholesterol (LDL-C) from baseline were characterized. A two-compartment disposition model with a transit absorption compartment and linear elimination best described bempedoic acid oral pharmacokinetics (PK). Multiple covariates, including renal function, sex, and weight, had statistically significant effects on the predicted steady-state area under the curve. Mild (estimated glomerular filtration rate (eGFR) 60 to < 90 mL/min vs. ≥ 90 mL/min) and moderate (eGFR 30 to < 60 mL/min vs. ≥ 90 mL/min) renal impairment, female sex, low (< 70 kg vs. 70–100 kg) and high (> 100 kg vs. 70–100 kg) body weight were predicted to have a 1.36-fold (90% confidence interval (CI) 1.32, 1.41), 1.85-fold (90% CI 1.74, 2.00), 1.39-fold (90% CI 1.34, 1.47), 1.35-fold (90% CI 1.30, 1.41), and 0.75-fold (90% CI 0.72, 0.79) exposure difference relative to their reference populations, respectively. An indirect response model described changes in serum LDL-C with a model-predicted 35% maximal reduction and bempedoic acid IC50 of 3.17 µg/mL. A 28% reduction from LDL-C baseline was predicted for a steady-state average concentration of 12.5 µg/mL after bempedoic acid (180 mg/day) dosing, accounting for approximately 80% of the predicted maximal LDL-C reduction. Concurrent statin therapy, regardless of intensity, reduced the maximal effect of bempedoic acid but resulted in similar steady-state LDL-C levels. While multiple covariates had statistically significant effects on PK and LDL-C lowering, none were predicted to warrant bempedoic acid dose adjustment.
Energy bounds for vertex operator algebra extensions
Authors: Carpi Sebastiano , Tomassini Luca 
Published: May 2023

AbstractLet V be a simple unitary vertex operator algebra and U be a (polynomially) energy-bounded unitary subalgebra containing the conformal vector of V. We give two sufficient conditions implying that V is energy-bounded. The first condition is that U is a compact orbifold $$V^G$$

V
G

for some compact group G of unitary automorphisms of V. The second condition is that V is exponentially energy-bounded and it is a finite direct sum of simple U-modules. As a consequence of the second condition, we prove that if U is a regular energy-bounded unitary subalgebra of a simple unitary vertex operator V, then V is energy-bounded. In particular, every simple unitary extension (with the same conformal vector) of a simple unitary affine vertex operator algebra associated with a semisimple Lie algebra is energy-bounded.
Effects of electromagnetic waves on the moisture content of cones and the quality of extracted seeds in the Norway spruce and European larch
Authors: Aniszewska Monika , Gendek Arkadiusz , Tulska Ewa , Zięba-Kawecka Aleksandra , Malaťák Jan , Tamelová Barbora , Malaťáková Jitka , Krilek Jozef 
Published: May 2023

AbstractThe publication describes research investigating the effects of microwaves on seeds extracted from Norway spruce (Picea abies) and European larch (Larix decidua) cones. The objective of the conducted experiments was to determine how electromagnetic radiation influences the quality of those seeds. The study material was heated in a microwave-emitting device for 7 or 10 s at four power settings (800, 620, 440, or 130 W). The evaluated parameters included changes in the moisture content and weight of the studied cones following the applied time and power variants of exposure to microwaves, as well as the quality of the obtained seeds expressed in terms of germination energy (GE) and capacity (GC). Increasing the power of microwaves resulted in a greater decrease in the moisture content of cones, but it was not possible to find such a relationship for larch cones, especially for large cones. In most cases, the irradiation of larch cones with electromagnetic waves resulted in class I seeds, in contrast to spruce seeds, which could not be assigned to any class. Our findings show that for optimum results larch cones may be exposed to microwaves at a power not greater than 620 W and for a time not longer than 10 s. Spruce cones were found to be very sensitive to radiation; in their case no microwave treatment should be applied as it adversely affects seed viability.
Ph.D. publication productivity: the role of gender and race in supervision in South Africa
Authors: Rossello Giulia , Cowan Robin , Mairesse Jacques 
Published: May 2023

AbstractWe study whether student-advisor gender and race composition matters for publication productivity of Ph.D. students in South Africa. We consider all Ph.D. students in STEM graduating between 2000 and 2014, after the recent systematic introduction of doctoral programs in this country. We investigate the joint effects of gender and race for the whole sample and looking separately at the sub-samples of (1) white-white; (2) black-black; and (3) black-white student-advisor couples. We find significant productivity differences between male and female students. These disparities are more pronounced for female students working with male advisors when looking at the joint effects of gender and race for the white-white and black-black student-advisor pairs. We also explore whether publication productivity differences change significantly for students with a high, medium, or low “productivity-profile”. We find that female productivity gaps are U-shaped over the range of productivity. Female students working with male advisors have more persistent productivity gaps over the productivity distribution, while female students with a high (or low) “productivity-profile” studying with female advisors are as productive as male students with similar “productivity-profile” studying with male advisors.
Does local government corruption inhibit entrepreneurship?
Authors: Wittberg Emanuel , Erlingsson Gissur Ó. , Wennberg Karl 
Published: May 2023

AbstractThe
dominant ‘sand in the wheels’ view holds that entrepreneurship is strongly inhibited by corruption. Challenging this, the ‘grease the wheels’ view maintains that corruption might increase entrepreneurship in highly regulated economies. We extend the basic predictions of these theories by examining entrepreneurs’ start-up decisions, as well as their location choices, in a seemingly low-corruption environment: Swedish municipalities. Combining a validated index of corruption perceptions in local government with population data on new entrepreneurs, nested logit models reveal that even in a low-corruption setting such as Sweden, perceptions of corruption can deter latent entrepreneurs. We also find that a minority of entrepreneurs relocate from their home municipalities to establish their start-ups elsewhere. Surprisingly and contrary to expectations, these relocating entrepreneurs often relocate from relatively low-corruption municipalities to others that are more corrupt. Implications for future research and public policy are discussed.