bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Metal–Organic Frameworks for Maximizing Transconductance of Organic Photoelectrochemical Transistor at Zero Gate Bias and Biological Interfacing Application
Authors: Gao Ge , Chen Jia‐Hao , Jing Ming‐Jian , Hu Jin , Xu Qin , Wang Cheng‐Shuang , Zhou Hong , Lin Peng , Chen Guangxu , Zhao Wei‐Wei 
Published: February 2023

AbstractOrganic electrochemical transistors showing maximum transconductance (gm) at zero gate bias (VG) is desired but has long been a challenge. To date, few solutions to this issue are available. Light‐matter interplay is shown as rich sources for optogenetics, photodynamic therapy, and advanced electronics, but its potential in gm modulation are largely untapped. Herein, the challenge is addressed by unique light‐matter interplay in the newly emerged technique of organic photoelectrochemical transistor (OPECT), which is exemplified by dual‐ligand photosensitive metal–organic frameworks (DL‐PS‐MOFs)/TiO2 nanorods (NRs) gated poly(ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) OPECT under 425 nm light irradiation. Interestingly, the light stimulation on the DL‐PS‐MOFs can de‐dope PEDOT:PSS with altered transistor physics, achieving device showing maximum gm at zero VG and the simultaneous superior output of channel current. In connection to a cascade catalytic hairpin assembly‐rolling circle amplification strategy, such a device is then biologically interfaced with a miRNA‐triggered growth of DNA spheres for the sensitive detection of miRNA‐21 down to 0.12 fm. This work features a proof‐of‐concept study using light‐matter interplay to enable organic transistors showing maximum gm at zero VG and its sensitive biological interfacing application.
Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy
Authors: Song Xinran , Zhang Qin , Chang Meiqi , Ding Li , Huang Hui , Feng Wei , Xu Tianming , Chen Yu 
Published: February 2023

AbstractNanomedicine‐enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US‐based biomedicine, overcoming the shortcomings of traditional microbubbles and optimizing the design of contrast and sonosensitive agents. The single‐faceted summary of available US‐related therapies is still a significant drawback. Here, The proposal of a comprehensive review on the recent advances of sonosensitive nanomaterials in advancing four US‐related biological applications and disease theranostics is aimed. In addition to the mostly explored nanomedicine‐enabled/augmented sonodynamic therapy (SDT), the summary and discussion of other sono‐therapies and progresses/achievements are relatively lacking, including sonomechanical therapy (SMT), sonopiezoelectric therapy (SPT), and sonothermal therapy (STT). The design concepts of the specific sono‐therapies based on nanomedicines are initially introduced. Furthermore, the representative paradigms for nanomedicine‐enabled/enhanced US therapies are elaborated according to therapeutic principles and diversity. This review provides an updated and comprehensive review of the field of nanoultrasonic biomedicine, and comprehensively discusses the progress of versatile ultrasonic disease treatments. Finally, the deep discussion on the facing challenges and prospects is expected to promote the emergence and establishment of a new branch of US biomedicine through the rational combination of nanomedicine and US clinical biomedicine.
A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing
Authors: Xiong Yuan , Lin Ze , Bu Pengzhen , Yu Tao , Endo Yori , Zhou Wu , Sun Yun , Cao Faqi , Dai Guandong , Hu Yiqiang , Lu Li , Chen Lang , Cheng Peng , Zha Kangkang , Shahbazi Mohammad‐Ali , Feng Qian , Mi Bobin , Liu Guohui 
Published: February 2023

AbstractDiabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis and angiogenesis have appeared to be a promising direction. However, the current treatments have failed to coordinate neurogenesis and angiogenesis simultaneously, leading to an increased disability rate caused by DWs. Herein, a whole‐course‐repair system is introduced by a hydrogel to concurrently achieve a mutually supportive cycle of neurogenesis‐angiogenesis under a favorable immune‐microenvironment. This hydrogel can first be one‐step packaged in a syringe for later in situ local injections to cover wounds long‐termly for accelerated wound healing via the synergistic effect of magnesium ions (Mg2+) and engineered small extracellular vesicles (sEVs). The self‐healing and bio‐adhesive properties of the hydrogel make it an ideal physical barrier for DWs. At the inflammation stage, the formulation can recruit bone marrow‐derived mesenchymal stem cells to the wound sites and stimulate them toward neurogenic differentiation, while providing a favorable immune microenvironment via macrophage reprogramming. At the proliferation stage of wound repair, robust angiogenesis occurs by the synergistic effect of the newly differentiated neural cells and the released Mg2+, allowing a regenerative neurogenesis‐angiogenesis cycle to take place at the wound site. This whole‐course‐repair system provides a novel platform for combined DW therapy.
Self‐Doping Naphthalene Diimide Conjugated Polymers for Flexible Unipolar n‐Type OTFTs
Authors: Chen Pinyu , Wang Dongyang , Luo Liang , Meng Jinqiu , Zhou Zhaoqiong , Dai Xiaojuan , Zou Ye , Tan Luxi , Shao Xiangfeng , Di Chong‐an , Jia Chunyang , Zhang Hao‐Li , Liu Zitong 
Published: February 2023

AbstractThe development of high‐performance organic thin‐film transistor (OTFT) materials is vital for flexible electronics. Numerous OTFTs are so far reported but obtaining high‐performance and reliable OTFTs simultaneously for flexible electronics is still challenging. Herein, it is reported that self‐doping in conjugated polymer enables high unipolar n‐type charge mobility in flexible OTFTs, as well as good operational/ambient stability and bending resistance. New naphthalene diimide (NDI)‐conjugated polymers PNDI2T‐NM17 and PNDI2T‐NM50 with different contents of self‐doping groups on their side chains are designed and synthesized. The effects of self‐doping on the electronic properties of resulting flexible OTFTs are investigated. The results reveal that the flexible OTFTs based on self‐doped PNDI2T‐NM17 exhibit unipolar n‐type charge‐carrier properties and good operational/ambient stability thanks to the appropriate doping level and intermolecular interactions. The charge mobility and on/off ratio are fourfold and four orders of magnitude higher than those of undoped model polymer, respectively. Overall, the proposed self‐doping strategy is useful for rationally designing OTFT materials with high semiconducting performance and reliability.
DTRMWXHS‐12, a novel Bruton tyrosine kinase inhibitor, in combination with everolimus and pomalidomide in patients with relapsed/refractory lymphomas: An open‐label, multicenter, phase 1a/1b study
Authors: Huntington Scott F. , Schuster Stephen J. , Ding Wei , Koehler Amber B. , Brander Danielle M. , Rosenthal Allison C. , Leis Jose F. , Tun Han W. , Moustafa Muhamad Alhaj , Iqbal Madiha , He Wei , Kearney Albert S. , McKinlay Timothy P. , Gui Min , Mato Anthony R. 
Published: February 2023

AbstractPreclinical studies have shown augmented activity when combining Bruton tyrosine kinase inhibitors (BTKi) with inhibitors of mammalian target of rapamycin (mTOR) and immunomodulatory agents (IMiD). We conducted a phase 1, open‐label study at five centers in USA to evaluate the safety of triplet BTKi/mTOR/IMiD therapy. Eligible patients were adults aged 18 years or older with relapsed/refractory CLL, B cell NHL, or Hodgkin lymphoma. Our dose escalation study used an accelerated titration design and moved sequentially from single agent BTKi (DTRMWXHS‐12), doublet (DTRMWXHS‐12 + everolimus), and then to triplet therapy (DTRMWXHS‐12 + everolimus + pomalidomide). All drugs were dosed once daily on days 1–21 of each 28‐day cycle. The primary goal was to establish the recommended phase 2 dose of the triplet combination. Between September 27, 2016, and July 24, 2019, a total of 32 patients with a median age of 70 years (range 46 to 94 years) were enrolled. No MTD was identified for monotherapy and the doublet combination. The MTD for the triplet combination was determined to be DTRMWXHS‐12 200 mg + everolimus 5 mg + pomalidomide 2 mg. Responses across all studied cohorts were seen in 13 of 32 (41.9%). Combining DTRMWXHS‐12 with everolimus and pomalidomide is tolerable and shows clinical activity. Additional trials could confirm benefit of this all‐oral combination therapy for relapsed/refractory lymphomas.
Development of adiposity among Ju/’Hoansi Hunter‐Gatherers
Authors: Campbell Benjamin C. , Hackman Joe V. , Kramer Karen L. 
Published: February 2023

AbstractObjectivesTo characterize the development of childhood adiposity among the Ju’/Hoansi, a well‐known hunter‐gather group, to compare our results to U.S. references and to recently published results from Savanna Pume’ foragers of Venezuela, with the goal of expanding our understanding of adipose development among human hunter‐gatherers.MethodsTriceps, subscapular, and abdominal skinfolds, along with height and weight from ~120 Ju’/Hoansi girls and ~103 boys, ages 0 to 24 years, collected in 1967–1969 were analyzed using best‐fit polynomial models and penalized spines to characterize age‐specific patterns of adiposity and their relationship to changes in height and weight.ResultsOverall, Ju/’Hoansi boys and girls exhibit small skinfolds with a decline in adiposity from 3 to 10 years, with no consistent differences among the three skinfolds. Increases in adiposity during adolescence precede peak height and weight velocities. Adiposity declines during young adulthood for girls and remains largely constant for boys.DiscussionCompared to U.S. standards, the Ju/’Hoansi show a strikingly different pattern of adipose development, including the lack of an adiposity rebound at the onset of middle childhood, and clear increases in adiposity only at adolescence. These findings are consistent with published results from the Savanna Pumé hunter‐gatherers of Venezuela, a group with a very different selective history, suggesting that the adiposity rebound does not characterize hunter‐gathering populations more generally. Similar analyses in other subsistence populations are called for to confirm our results, and help distinguish the impact of specific environmental and dietary factors on adipose development.
Obesity impacts the expression of Alzheimer's disease–related genes: The Framingham Heart Study
Authors: Charisis Sokratis , Lin Honghuang , Ray Roshni , Joehanes Roby , Beiser Alexa S , Levy Daniel , Seshadri Sudha , Sargurupremraj Muralidharan , Satizabal Claudia L 
Published: February 2023

AbstractINTRODUCTIONWe investigated associations of obesity with the expression of Alzheimer's disease (AD)–related genes in a large community‐based cohort.METHODSThe sample consisted of 5619 participants from the Framingham Heart Study. Obesity metrics included body mass index (BMI) and waist‐to‐hip ratio (WHR). Gene expression was measured for a set of 74 AD‐related genes, derived by integrating genome‐wide association study results with functional genomics data.RESULTSObesity metrics were associated with the expression of 21 AD‐related genes. The strongest associations were observed with CLU, CD2AP, KLC3, and FCER1G. Unique associations were noted with TSPAN14, SLC24A4 for BMI, and ZSCAN21, BCKDK for WHR. After adjustment for cardiovascular risk factors, 13 associations remained significant for BMI and 8 for WHR. Dichotomous obesity metrics exhibited unique associations with EPHX2 for BMI, and with TSPAN14 for WHR.DISCUSSIONObesity was associated with AD‐related gene expression; these findings shed light on the molecular pathways linking obesity to AD.
Probing the Przybylski star for deuterium
Authors: Andrievsky Sergei M. , Kovtyukh Valery V. 
Published: February 2023

AbstractThe Przybylski star spectrum has been studied in order to search for deuterium lines. Since this star is extremely enriched in the s‐process elements, which are the product of interaction between free neutrons and seed nuclei, we might as well expect to detect deuterium in this star. However, no visible spectroscopic manifestation of deuterium has been detected. Perhaps, the reason of this result is the convective “destruction” of this isotope.
A novel “spectral‐ratio model fitting” to resolve complicated X‐ray spectral variations in active galactic nuclei
Authors: Midooka Takuya , Mizumoto Misaki , Ebisawa Ken 
Published: February 2023

AbstractRadiation‐magnetohydrodynamic simulation of the active galactic nuclei predicts the presence of the strong accretion disk wind, which gets unstable far from the central region and turns into gas clumps. These inner wind and outer clumps may be actually observed as the ultrafast outflows (UFOs) and the clumpy absorbers, respectively. We call this picture as the “hot inner and clumpy outer wind model.” Observationally, it is challenging to place constraints on the origin of the UFOs and clumpy absorbers due to complicated spectral variations. We developed a novel method, “spectral‐ratio model fitting,” to resolve parameter degeneracy of the clumpy absorbers and other spectral components. In this method, the parameters of the absorber in the line of sight are estimated from the ratio of the partially absorbed spectrum to the non‐absorbed one. We applied this method to the narrow‐line Seyfert 1 galaxy IRAS 13224–3809 observed byXMM‐Newtonin 2016 for 1.5 Ms, where the source showed extreme spectral variability and complex absorption features. As a result, we found that the soft spectral variation is mostly explained by a change in the covering fraction of the mildly‐ionized clumpy absorbers, and that these absorbers are outflowing with such a high velocity that is comparable to that of the UFO (∼0.2–0.3 c).
Preparation of nanopillar array electrode of iridium oxide for high performance of pH sensor and its real‐time sweat monitoring
Authors: Yoon Eun Seop , Park Hong Jun , Kil Min Sik , Kim Jueun , Lee Kyoung G. , Choi Bong Gill 
Published: February 2023

AbstractA highly sensitive potentiometric pH sensor was developed based on nanopillar array electrodes of iridium oxide. The as‐prepared pH sensor exhibited a high pH sensitivity (69.43 mV/pH), fast response time (8.1 s), and good durability (0.76 mV/h). The sensing performance of the pH sensor was maintained under mechanical bending and even after 1000 repetitive bending/releasing cycles. As a proof‐of‐concept, a wearable headband sensor was fabricated by integrating the pH sensor with a wireless electronic module based on a printed circuit board. The on‐body test indicated that the wearable pH sensor provides reliable and stable data in the real‐time monitoring of pH changes in human sweat during stationary indoor cycling. The pH sensors based on nanopillar array electrodes of iridium oxide have great potential in many portable or wearable applications in healthcare systems, non‐invasive diagnostics, environmental analysis, and food sensors.
A retrospective analysis of the prognosis of Japanese patients with sarcoma brain metastasis
Authors: Toda Yu , Kobayashi Eisuke , Kubota Daisuke , Miyakita Yasuji , Narita Yoshitaka , Kawai Akira 
Published: February 2023

AbstractBackgroundBone and soft tissue sarcomas are rare tumors and extremely rarely metastasize to the brain. Previous studies have examined the characteristics and poor prognostic factors in cases of sarcoma brain metastasis (BM). Due to the rarity of cases of BM from sarcoma, limited data exist concerning the prognostic factors and treatment strategies.MethodsA retrospective single‐center study was performed on sarcoma patients with BM. The clinicopathological characteristics and treatment options for BM of sarcoma were investigated to identify predictive prognostic factors.ResultsBetween 2006 and 2021, 32 patients treated for newly diagnosed BM at our hospital were retrieved among 3133 bone and soft tissue sarcoma patients via our database. The most common symptom was headache (34%), and the most common histological subtypes were alveolar soft part sarcoma (ASPS) and undifferentiated pleomorphic sarcoma (25%). Non‐ASPS (p = 0.022), presence of lung metastasis (p = 0.046), a short duration between initial metastasis, and the diagnosis of brain metastasis (p = 0.020), and the absence of stereotactic radiosurgery for BM (p = 0.0094) were significantly correlated with a poor prognosis.ConclusionsIn conclusion, the prognosis of patients with brain metastases of sarcomas is still dismal, but it is necessary to be aware of the factors associated with a relatively favorable prognosis and to select treatment options appropriately.
Essential Oil of Cestrum diurnum L.: GC/MS Analysis, in Vitro and in Silico Anti‐HCoV‐229E Effects and Inhibitory Activity against LPS‐Induced Inflammation
Authors: Bahgat Dina M. , Gad Haidy A. , Al‐Sayed Eman , Mahmoud Sara H. , Mostafa Ahmed , Mahfouz Nadia M. , Eldahshan Omayma A. , Nasser B. Singab Abdel 
Published: February 2023

AbstractCestrum diurnum L. (Solanaceae) is a fragrant ornamental tree cultivated in different parts around the world. In this study, the essential oil (EO) of the aerial parts was extracted by hydrodistillation (HD), steam distillation (SD) and microwave‐assisted hydro‐distillation (MAHD). GC/MS analysis of the three EOs revealed that phytol represents the major component in SD‐EO and MAHD‐EO (40.84 and 40.04 %, respectively); while in HD‐EO it only represented 15.36 %. The SD‐EO showed a strong antiviral activity against HCoV‐229E with IC50 of 10.93 μg/mL, whereas, MAHD‐EO and HD‐EO showed a moderate activity with IC50 values of 119.9 and 148.2 μg/mL, respectively. The molecular docking of EO major components: phytol, octadecyl acetate and tricosane showed a strong binding to coronavirus 3‐CL (pro). Moreover, the three EOs (50 μg/mL) decreased the levels of NO, IL‐6 and TNF‐α and suppressed IL‐6 and TNF‐α gene expression in LPS‐induced inflammation model in RAW264.7 macrophage cell lines.
Design and Synthesis of (3‐Phenylisoxazol‐5‐yl)methanimine Derivatives as Hepatitis B Virus Inhibitors
Authors: Liang Zhengcheng , Tan Yongqing , Huang Yunhou , Liang Taoyuan , Wei Wanxing , Wang Mian , Shi Kaichuang 
Published: February 2023

AbstractSeries of (3‐phenylisoxazol‐5‐yl)methanimine derivatives were synthesized, and evaluated for anti‐hepatitis B virus (HBV) activity in vitro. Half of them more effectively inhibited HBsAg than 3TC, and more favor to inhibit secretion of HBeAg than to HBsAg. Part of the compounds with significant inhibition on HBeAg were also effectively inhibit replication of HBV DNA. Compound (E)‐3‐(4‐fluorophenyl)‐5‐((2‐phenylhydrazineylidene)methyl)isoxazole inhibited excellently HBeAg with IC50 in 0.65 μM (3TC(Lamivudine) in 189.90 μM), inhibited HBV DNA in 20.52 μM (3TC in 26.23 μM). Structures of compounds were determined by NMR and HRMS methods, and chlorination on phenyl ring of phenylisoxazol‐5‐yl was confirmed by X‐ray diffraction analysis, and the structure–activity relationships (SARs) of the derivatives was discussed. This work provided a new class of potent non‐nucleoside anti‐HBV agents.
Supramolecular Interactions‐Assisted Polymorphism and Unique Mechanofluorochromism in 9,10‐Bis((E)‐4‐(trifluoromethyl)styryl)anthracene
Authors: Suresh Sumi K. , Raju Princy Deni , Krishnan Aravind , Ramachandran Lekshmi M. , Suneesh Chettiyam Veettil 
Published: February 2023

AbstractA fluorinated distyrylanthracene (DSA) derivative, 9, 10‐bis((E)‐4‐(trifluoromethyl)styryl)anthracene abbreviated as4FDSAwith two crystalline polymorphs (4FDSA‐G(green emission) and4FDSA‐O(orange emission)), showing remarkable aggregation‐induced enhanced emission and mechanofluorochromic characteristics, was developed. One of the polymorphs in its crystalline arrangement exhibits the hardly seen F…F interactions. It questions the conventional belief of the non‐polarisable nature of fluorine atoms in forming the halogen bond. The twisted molecular conformation facilitated by the various supramolecular interactions resulted in the formation of another intensely emissive bluer nanocrystal (4FDSA‐NC) at aggregating conditions. Even though, the both polymorphs show distinct tricolor luminescence switching on the action of mechanical force, fumigation of ground crystals with solvent vapor resulted in the formation of a more thermodynamically favorable4FDSA‐NCform. The work demonstrates the effect of supramolecular interactions assisted conformational changes in tuning the unique mechanofluorochromic characteristics of the polymorphic crystals.
Progress in Predicting Ionic Cocrystal Formation: The Case of Ammonium Nitrate
Authors: Bennett Andrew J. , Matzger Adam J. 
Published: February 2023

AbstractIn contrast to the mature predictive frameworks applied to neutral cocrystals, ionic cocrystals, those including an ion pair, are difficult to design. Furthermore, they are generally excluded categorically from studies which correlate specific molecular properties to cocrystal formation, leaving the prospective ionic cocrystal engineer with few clear avenues to success. Herein ammonium nitrate, an energetic oxidizing salt, is targeted for cocrystallization in a potential coformer group selected based on likely interactions with the nitrate ion as revealed in the Cambridge Structural Database; six novel ionic cocrystals were discovered. Molecular descriptors previously identified as being related to neutral cocrystal formation were examined across the screening group but showed no relationship with ionic cocrystal formation. High packing coefficient is shown to be a constant among the successful coformers in the set and is utilized to directly target two more successful coformers, bypassing the need for a large screening group.
Mo Cluster Support on C2N as a Highly‐efficient Catalyst for Electrocatalytic Nitrogen Reduction Reaction
Authors: Chen Yuke , Zhao Ming , Wang Zhili , Jiang Qing 
Published: February 2023

AbstractThe conversion of nitrogen to ammonia by electrocatalysis under mild conditions is a valuable research direction, which has been a sustainable alternative to the traditional Haber‐Bosch method. However, the conversion remains a huge challenge in chemistry at this time. In this work, the density functional theory (DFT) is used to study the electrocatalytic nitrogen reduction reaction (NRR) performance of Mo12 clusters on C2N monolayer (Mo12−C2N). It is found that the diversity of active sites of the Mo12 cluster provides favorable reaction paths for intermediates, which reduces reaction barrier of NRR. Mo12−C2N shows excellent NRR performances with limiting potentials of −0.26 V vs. reversible hydrogen electrode (RHE).