bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cost-Effectiveness Analysis Of Intraoperative Autologous Transfusion In Adolescent Idiopathic Scoliosis Surgery: A Single-center Retrospective Study
Authors: Chi Wen , Luo Zhenguo , Wu Zanqing , Hao Jianhong 
Published: March 2023

Abstract
Background: Intraoperative autologous transfusion(IAT) has been used in scoliosis surgery for decades; however, its cost-effectiveness remains debatable. Therefore, this study aimed to evaluate the cost-effectiveness of IAT in adolescent idiopathic scoliosis (AIS) surgery with different blood loss volumes.
Methods: The medical records of 402 patients who underwent AIS surgery were reviewed. Depending on the volume of blood lost during the operation, the patients were divided into three groups: A (≥500 to <1000 mL), B (≥1,000 to <1,500 mL), and C (≥1,500mL). Depending on whether IAT was used, each group was further divided into the IAT and no-IAT groups. The volume of blood loss, volume of transfused allogeneic red blood cells (RBC),and RBC transfusioncosts were analyzed.Univariate and multivariate logistic regression analyses were used to identify the independent risk factors of massive intraoperative blood loss (≥1,000 mL and ≥1,500 mL). A receiver operating characteristic (ROC) curve was used to analyze the cutoff values of the factors contributing to massive intraoperative blood loss.
Results: In group B, the IAT group had a lower volume of allogeneic RBC transfused than the no-IAT group, whereas the total RBC transfusion cost in the IAT group was significantly higher than that in the no-IAT group. In group C, the volume of allogeneic RBC transfused in the IAT group reduced significantly more than that in the no-IAT group. The number of vertebral levels fused was found to be an independent risk factor for massive intraoperative blood loss.
Conclusion: The cost-effectiveness of IAT in AIS is related to the volume of blood lost. The number of fused vertebral levels is an independent risk factor that can effectively predict massive intraoperative blood loss.
Elective surgery cancellations in pediatric surgery: rate and reasons
Authors: Mansour Maha Ben , Lassioued Oussama , Chakroun Sawsen , Slimene Amine Ben , Youssef Sabrine Ben , Ksiaa Amine , Gahbiche Mourad 
Published: March 2023

Abstract
Introduction: Canceling pediatric elective surgery leads to multiple disturbances regarding the inefficient operating room (OR) management, the financial repercussions, and the psychological impact on the patient and his family. This study aims to identify the reasons for cancellations among the pediatric population in our setting and suggest some convenient solutions.
Methods: We carried out a prospective and descriptive study over 12 months in the pediatric surgery department of Fattouma Bourguiba University Hospital.
Results: 1426 patients were scheduled for surgery at the pediatric surgery department, of whom 131 (9.2%) were canceled. Medical and anesthesia-related reasons accounted for 62.6% of all cancellations, followed by surgical reasons at 16 %, organizational or administrative issues at 11.5%, and patient-related reasons at 10 %. The most significant causes were upper respiratory tract infections (URTIs) in 36.6%, abnormal blood test results in 16%, and non-adherence to preoperative fasting in 9.2%.
Conclusions: The rate of pediatric elective surgery cancellations at Fattouma Bourguiba University Hospital was higher than the accepted average rate (5%). Therefore, to prevent these cancellations as much as possible, efforts should be made to promote children's medical care, operation scheduling, and efficient institution resource utilization.
General Practitioner perceptions and experiences of managing perinatal mental health: a scoping review
Authors: Frayne Jacqueline , Seddon Sarah , Lebedevs Tamara , Milroy Talila , Teh Beverly , Nguyen Thinh 
Published: March 2023

Abstract
Background
General Practitioners (GPs) manage the majority of preconception, early pregnancy, and postnatal care. Overall, mental health remains a significant contributor to disease burden affecting 1 in 4 pregnant women. Psychotropic medication prescribing occurs in almost 1 in 12 pregnancies, and appears to be increasing, along with the prevalence of mental health disorders in women of reproductive age. Perinatal mental health management is therefore not an unlikely scenario within their clinical practice. This scoping review aims to map current research related to GPs perceptions and experiences managing perinatal mental health, particularly exploring their experiences of diagnosis, medication use, guideline adherence and management of care.
Method
A comprehensive search strategy using nine electronic databases, and grey literature was undertaken between December 2021 and February 2023. Relevant studies were sourced from peer review databases using key terms related to perinatal mental health and general practitioners. Search results were screened on title, abstract and full text to assess those meeting inclusion criteria and relevance to the research question.
Results
After screening, 16 articles were included in the scoping review. The majority of articles focused on perinatal depression. Findings support that GPs are largely confident with diagnosing perinatal depression. However, over the last two decades, prescribing confidence in perinatal mental health remains variable with concerns for the safety profile of medication, low level of confidence in providing information and a strong reliance on personal experience. Despite the establishment of perinatal guidelines by countries, the utilisation of these and other existing resources by GPs appears to be infrequent. Many challenges exist for GPs around time pressures, a lack of information and resources, and difficulty accessing referral to services.
Conclusion
Recommendations following this scoping review include targeted perinatal education programs specific for GPs and embedded in training programs. The development of practice guidelines and resources specific to general practice that recognises time, services, and funding limitations. Future research is needed on how guidelines and resources can be developed and best delivered to optimise GP engagement to improve knowledge and enhance patient care.
Evaluation of the Acute flaccid paralysis surveillance indicators in Zambia from 2015-2021: A retrospective analyses
Authors: Bessing Barnabas , Dagoe Edward A. , Tembo Deborah , Kanyanga Muzala Kapina , Matapo Belem B , Mwangombe Alice , Bobo Patricia M. , Manneh Fadinding , Chipoya Musole , Eboh Victor A. , Kayeye Princess L. , Masumbu Penelope K. , Muzongwe Chilweza , Bakyaita Nathan N. , Zomahoun Delayo , Tuma Jude N. 
Published: March 2023

Abstract
Background: The resurgence of poliovirus infection in previously polio free regions and countries calls for renewed commitment to the global polio eradication efforts including strengthening of Acute Flaccid Paralysis (AFP) surveillance systems. Zambia is one of the countries substantially at risk for the importation of poliovirus infection from neighbouring countries including Malawi, Mozambique, and Democratic Republic of the Congo (DRC). This study describes a seven-year AFP surveillance, assesses the surveillance indicators, and highlights areas for improvement.
Methods: We conducted retrospective analyses of the routinely collected AFP surveillance data from January 2015 to December 2022. The AFP surveillance indicators performance was assessed using the World Health Organisation’s recommended minimum AFP surveillance indicators performance.
Results: Cumulatively, a total of 1715 AFP cases were reported over the study period. More than half, 891 (52%) of reported cases were aged <5 years with 917 (53.5%) of males. More than half, 1186 (69.2%) had fever at onset, 718 (41.9%) had asymmetric paralysis and 1164 (67.9%) had their paralysis progressed within 3 days of onset. The non-polio AFP rate ranges from 3.4 to 6.4 per 100,000 children < 15 years old and stool adequacy ranging from 70.9% to 90.2% indicating sensitive surveillance with late detection of cases. The percentage of cases with early stool collection, timely transportation was above the World Health Organisation (WHO) minimum of 80% but with declining proportion of stools arriving in the laboratory in optimal condition. Completeness of 60-days follow-up evaluation was suboptimal ranging from 0.9% to 28.2%.
Conclusion: The AFP surveillance system in Zambia is doing well. However, additional efforts are needed to improve early detection of cases; stool sample collection, transportation and monitoring to ensure arrival in good condition in the laboratory; and improve 60-days follow-up evaluation for evidenced-based classification of inadequate AFP cases and proper care.
"Ser Criança" – an oral health literacy program for vulnerable children and families
Authors: Veiga Nélio Jorge , Mello-Moura Anna Carolina Volpi , Dias Beatriz , Oliveira Mário , Correia Patrícia , Couto Patrícia , Correia Maria , Duarte Ana 
Published: March 2023

AbstractBackground:Over the years, there has been an increasing and effective integration and participation of oral health in the concept of general health. The absence of educational interventions, and behavioral strategies for children´s oral health are still considered gaps in today's society. The main objective of this work was to define strategies of educational interventions in children's oral health.Methods:The intervention for the “Ser Criança” Program involved the development of a website - “Ser Criança – Aprender a Sorrir” (A Child - Learn to Smile) for three target groups: children, parents and educators / teachers. With this proposition, it is expected that children, families, and school communities improve behavioral habits related to oral health. Also, the “Ser Criança” Program involves a specific protocol defining oral health literacy strategies and dental appointments among the children and families.Results:The “Ser Criança” Program involves a specific protocol defining oral health literacy strategies and dental appointments for children and families. It is crucial to emphasize that most recreational activities are beneficial in the transmission of motivational values. The use of educational games, exploration of macro dental models, theatre and music are valid examples of these activities. Interventions based on digital media (applications or"apps"and the Internet) also prove to be a constant demonstration of success for children's personal and cognitive growth. Aiming on a digital tool for pre-school and elementary school children, through a web-based platform allows, especially amongst the hard-to-reach communities, an immeasurable access to multiple possibilities.Conclusions:Educating future generations using attractive educational, didactic and, above all pedagogical interventions can greatly improve health interventions, especially in the field of dental medicine.
The general attributes and competence for nurses in a single responder unit. A modified Delphi study.
Authors: Tikkanen Viivi , Arsic Marija , Henricson Maria 
Published: March 2023

Abstract
Aim
The aim of this study was to describe the general attributes and competence that nurses in the ambulance's single responder units are considered to need.
Background
The development of ambulance care has led to an increased need for new units and working methods. Single responder unit is a single crewed unit that often uses for the patient assessments, to refer patients to the right level of care and to release regular ambulances. There is a lack of description of the needed competence for the nurses within single responder unit.
Methods
Modified Delphi with three rounds was used. The first round was conducted with focus group interviews and analysed with content analysis. The second and third rounds were conducted through surveys using a 4-point Likert scale and analysed with descriptive statistics.
Results
Five competence categories were identified. 39 of 80 statements reached consensus. The ability to communicate with other actors to achieve one’s goal, the ability to create a good encounter alone and to have appropriate professional experience were identified as the most important general attributes and competencies.
Conclusions
Increased understanding of the needed competence within single responder unit can be implemented in prehospital recruitment and education. Further research on the function of single responder unit and the most appropriate formal competence of the emergency nurses in single responder units is needed.
Management of anomalous origin of right coronary artery from left coronary sinus
Authors: Mangel Tobin , Divya Aabha , De Silva Ravi 
Published: March 2023

Abstract
Aberrant origin of coronary artery is a rare congenital anomaly associated with increased risk of myocardial ischemia and sudden death, with the highest risk lesions being those arising from the opposite sinus of Valsalva. The unpredictable nature of the anomalous origin of coronary artery from the opposite sinus warrants surgical correction and reimplantation is a safe, effective and reproducible technique. We report a case with an aberrant right coronary artery arising superior to the left coronary cusp, with a slit-like ostium, having an interarterial and intramural course through the aortic root, that underwent repositioning of the right coronary artery.
Mesoscopic Study on Seepage Characteristics with Shear Displacement in a Single Fracture
Authors: Feng Peichao , Ma Haichun , Qian Jiazhong , Deng Yaping 
Published: March 2023

Abstract
To understand the change of fluid hydraulic behavior in the fracture under different shear displacements, fluid flow simulation at different flow velocity is carried out based on the Navier-Stokes equation. We characterize and make statistics on the change and distribution of fracture aperture under different shear displacements, especially the measurement of the contact area under shear displacement, which is helpful to accurately study the effect of shear displacement on fracture fluid flow. The research results show the shear displacement of the fracture can be regarded as the dislocation between the upper and lower fracture surfaces. The fluid flow velocity becomes larger near the contact sites, and the streamlines become denser. The resulting hydraulic aperture shows a negative correlation with the contact area. The relationship between volumetric flow rate and pressure gradient during flow field simulation can be well fitted by the Forchheimer equation, and the steepness of the curves is related to the contact area. The linear coefficient a and the nonlinear coefficient b in the Forchheimer equation are positively correlated with the contact area. From the measured flow velocity, the mechanical aperture is usually an order of magnitude larger than the hydraulic aperture. The linear relationship between mechanical aperture and hydraulic aperture is described. The positive correlation between permeability and mechanical aperture profiled during shear explains the hydraulic behavior in the flow field.
Comparison of minimally invasive transforaminal lumbar interbody fusion and endoscopic lumbar interbody fusion for lumbar degenerative diseases: a retrospective observational study
Authors: Chen Hao , Zheng Goudi , Bian Zhenyu , Hou Changju , Li Maoqiang , Zhang Zhen , Zhu Liulong , Wang Xuepeng 
Published: March 2023

Abstract
Background: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and endoscopic lumbar interbody fusion (Endo-LIF) are both new minimally invasive interbody fusion procedures for lumbar degenerative diseases. In this study, we attempted to compare the clinical efficacy and postoperative outcomes of MIS-TLIF and Endo-LIF for lumbar degenerative diseases.
Methods: The study cohort comprised 99 patients with lumbar degenerative diseases treated by MIS-TLIF or Endo-LIF from January 2019 to July 2021. The clinical outcomes (visual analogue scale (VAS), Oswestry disability index (ODI), and MacNab criteria) preoperatively, 1 month postoperatively, 3 months postoperatively, and 1 year postoperatively were compared between the two groups.
Results: There were no significant differences between the two groups in sex, age, disease duration, affected spine segment, and complications (P > 0.05). The operation time was significantly longer in the Endo-LIF group than the MIS-TLIF group (155.25 ± 12.57 vs. 123.14 ± 14.50 minutes; P < 0.05). However, the Endo-LIF group had a significantly smaller blood loss volume (61.79 ± 10.09 vs. 259.97 ± 14.63 ml) and shorter hospital stay (5.46 ± 1.11 vs. 7.06 ± 1.42 days) than the MIS-TLIF group. In both groups, the ODI and VAS scores for lower back pain and leg pain were significantly lower at each postoperative timepoint than preoperatively (P < 0.05). Although there were no significant differences between the two groups in the ODI and VAS scores for lower back pain and leg pain (P > 0.05), the VAS for lower back pain was lower in the Endo-LIF group than the MIS-TLIF group at each postoperative timepoint. The MacNab criteria showed that the improvement rate was 92.2% in the MIS-TLIF group and 91.7% in the Endo-LIF group, with no significant difference between the two groups (P > 0.05).
Conclusions: There were no signiﬁcant differences in short-term surgical outcomes between the MIS-TLIF and Endo-LIF groups. Compared with the MIS-TLIF group, the Endo-LIF group incurred less damage to surrounding tissues, experienced less intraoperative blood loss, and had less lower back pain, which is more conducive to recovery.
Characterization of loss of Y chromosome in peripheral blood of Chinese Han male patients with schizophrenia
Authors: Jiang Lanrui , Song Mengyuan , Song Feng , Zhou Yuxiang , Yao Hewen , Li Gangqin , Luo Haibo 
Published: March 2023

Abstract
Background
Schizophrenia has a global prevalence of 1% and is a threat to life expectancy and mortality. There is growing evidence that the risk of developing this disorder is higher in males than in females and tends to develop in early adulthood. The Y chromosome is thought to be involved in biological processes other than sex determination and spermatogenesis that affect male health and disease. Studies have found that Loss of Y chromosome (LOY) in peripheral blood is associated with a variety of diseases, cancer and increased all-cause mortality, so an analysis of the relationship between LOY and schizophrenia is warranted.
Methods
The study included 442 Chinese males (271 patients with schizophrenia vs 171 controls). The copy numbers of Y and X chromosome were detected by the positive droplets targeted with Amelogenin gene (AMEL) located on the Y chromosome and X chromosome (AMELY and AMELX) using droplet digital PCR (ddPCR), respectively. The LOY percentage was defined as the difference between the concentration of AMELX and the concentration of AMELY divided by the concentration of AMELX, denoted as (X - Y)/X.
Results
There was no significant difference in the presence of LOY between the schizophrenia and control groups in Chinese Han population. A remarkable correlation was found between the disease duration and (X - Y)/X ratio by using the mean (R2 = 0.51, p = 0.032). The logistic regression analysis implied that the risk of suffering LOY increases by 5.8% and 5.7% per year with age at onset and duration of the disease, respectively (ponset = 0.013, pduration = 0.017).
Conclusions
For the Chinese Han population, age of onset and duration of schizophrenia might be risk factors for LOY development in peripheral blood. More clinical information and larger sample size need to be collected for more in-depth and specific analyses.
Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis
Authors: liu Ya-qian , Xu Yue-chen , Xu Shen-qian , Shuai Zong-wen 
Published: March 2023

Abstract
Purpose: Clinical studies have found 14-3-3η to be associated with osteoporosis through undefined mechanisms. We aimed to investigate the role of 14-3-3η in osteoporosis and its potential associations with miRNAs.
Patients and methods:The Gene Expression Omnibus(GEO) and Human Protein Atlas(HPA) databases were analyzed to examine both the mRNA and protein expression of 14-3-3η in OP. Gene enrichment analyses were performed to explore the underlying mechanism of 14-3-3η based on DAVID. miRWalk was used to predict the associated miRNAs. The statistic were analysed by R software and SPSS software. 14-3-3η was overexpressed and knock down expressed in BMSCs by lentiviral vector transfecting. qRT-PCR and Western-Blot verified the expression of mRNA and protein. Scratch assay detected the migration of osteocytes. Co-immunoprecipitation and luciferase assay studied the 14-3-3η targeted protein and miRNA. overexpression and knock down of miRNA to verify the relationship of 14-3-3η and target genes.
Results: The 14-3-3η mRNA expression level was low in patients with osteoporosis, as corroborated by immunohistochemical staining images. Functional analyses revealed enrichment of the MAPK-associated cascade. 14-3-3η was correlated with MAPK family proteins and five key miRNAs, including mir-142-3p. In addition, 14-3-3η knockdown in BMSCs increased the mRNA and protein expression levels of Hif-α, VEGF, BMP-2, OPN, OST, and Runx2, and enhanced the cells migration ability. Under hypoxic conditions, Hif-α and BMP-2 protein expression levels were upregulated, whereas those of 14-3-3η and MAPK3 were downregulated. Co-immunoprecipitation experiments showed decreased binding of 14-3-3η to MAPK3. 14-3-3η knockdown produced the same results as hypoxia induction. Adding caspase3 inhibitor and knocking down 14-3-3η again prevented MAPK3 cleavage by caspase3 and inhibited BMP-2 expression. Moreover, under hypoxic conditions, miR-142-3P expression was upregulated and luciferase assays revealed 14-3-3η as its target gene. miR-142-3P overexpression decreased mRNA and protein levels of 14-3-3η and MAPK3, while increasing BMP-2 expression. miR-142-3P knockdown reversed these results.
Conclusions: 14-3-3η inhibited BMSC osteogenesis, while miRNA-142-3p enhanced it by inhibiting 14-3-3η.
Diabetes Mellitus and Latent Tuberculosis Infection: An Updated Meta-Analysis and Systematic Review
Authors: Zhou Guozhong , Guo Xin , Cai Shunli , Zhang Yu , Zhou Yuanyuan , Long Rong , Zhou Yingchen , Li Hanse , Chen Nan , Song Chao 
Published: March 2023

Abstract
Background
Previous studies have shown an association between diabetes mellitus (DM) and latent tuberculosis infection (LTBI), but there is limited evidence on the association between diabetes and LTBI. This study was conducted to systematically assess the association between DM and LTBI.
Methods
We searched Embase, Cochrane Library, and PubMed with no start date or language restrictions on July 19, 2022. Observational studies providing adjusted effect estimates of the association between DM and LTBI were included. The methodological quality of eligible studies was assessed, with pooled effects estimated using random-effects models with risk ratios (RRs), odds ratios (ORs), and their 95% confidence intervals (CIs).
Results
We included 22 studies involving 68,256 subjects. Three cohort studies were eligible, with an RR of 1.69 (95% CI: 0.79–3.64). Nineteen cross-sectional studies were eligible, with a pooled OR of 1.23 (95% CI: 1.06–1.43). Although not reaching statistical significance, the pooled OR of contacts and immigrants was higher than that of community residents (pooled OR: 1.51, 95% CI: 1.23–1.86 versus 1.19, 95% CI: 0.66–2.14, respectively). In addition, the pooled OR was higher in the diabetes group using HbA1c diagnosis than in the self-reported diabetes group, with pooled OR values of 1.38 (95% CI: 0.83–2.29) and 1.18 (95% CI: 1.00–1.40), respectively.
Conclusion
Diabetes is associated with a small but statistically significant risk of LTBI. Nonetheless, the economic benefit of screening for LTBI in people with DM may be low. In those at high risk of TB infection who underwent a rigorous diagnosis of DM, the association between DM and LTBI may be increased. Our study shows that screening for LTBI in people with diabetes who have high risk factors for TB can help prevent diabetes and TB co-infection.