bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obscured AGN enhancement in galaxy pairs at cosmic noon: evidence from a probabilistic treatment of photometric redshifts
Authors: Dougherty Sean L , Harrison C M , Kocevski Dale D , Rosario D J 
Published: May 2023

ABSTRACT
Observations of the nearby universe reveal an increasing fraction of active galactic nuclei (AGNs) with decreasing projected separation for close galaxy pairs, relative to control galaxies. This implies galaxy interactions play a role in enhancing AGN activity. However, the picture at higher redshift is less established, partly due to limited spectroscopic redshifts. We combine spectroscopic surveys with photometric redshift probability distribution functions for galaxies in the CANDELS and COSMOS surveys, to produce the largest ever sample of galaxy pairs used in an AGN fraction calculation for cosmic noon (0.5 &lt; z &lt; 3). We present a new technique for assessing galaxy pair probability (based on line-of-sight velocities ±1000 km s−1) from photometric redshift posterior convolutions and use these to produce weighted AGN fractions. Over projected separations 5–100 kpc, we find no evidence for enhancement, relative to isolated control galaxies, of X-ray (LX &gt; 1042 erg s−1) or infrared-selected AGN in major (mass ratios up to 4:1) or minor (4:1 to 10:1) galaxy pairs. However, defining the most obscured AGN as those detected in the infrared but not in X-rays, we observe a trend of increasing obscured AGN enhancement at decreasing separations. The peak enhancement, relative to isolated controls, is a factor of 2.08 ± 0.61 for separations &lt;25 kpc. Our simulations with mock data, indicates this could be a lower limit of the true enhancement. If confirmed with improved infrared imaging (e.g. with JWST) and redshifts (e.g. with forthcoming multi-object spectrograph surveys), this would suggest that galaxy interactions play a role in enhancing the most obscured black hole growth at cosmic noon.
The phase structure of cosmic ray driven outflows in stream fed disc galaxies
Authors: Peschken N , Hanasz M , Naab T , Wóltański D , Gawryszczak A 
Published: May 2023

ABSTRACT
Feeding with gas in streams is well established to be an important galaxy growth mechanism. Using an idealized set-up of an isolated galaxy, we study the impact of stream feeding (with 107 M⊙ Myr−1 rate) on the star formation and outflows of disc galaxies with ∼1011 M⊙ baryonic mass. The magnetohydrodynamical simulations are carried out with the piernik code and include star formation, feedback from supernova, and cosmic ray advection and diffusion, on a uniform grid with 195 pc spatial resolution. We find that the introduction of a cold gas stream accreted by the disc enhances galactic star formation. Lower angular momentum streams result in more compact discs, higher star formation rates and stronger outflows. In agreement with previous studies, models including cosmic rays launch stronger outflows travelling much further into the galactic halo. Cosmic ray supported outflows are also cooler than supernova only driven outflows. With cosmic rays, the star formation is suppressed and the thermal pressure is reduced. We find evidence for two distinct outflow phases. The warm outflows have high angular momentum and stay close to the galactic disc, while the hot outflow phase has low angular momentum and escapes from the centre deep into the halo. Cosmic rays can therefore have a strong impact on galaxy evolution by removing low angular momentum, possibly metal enriched gas from the disc and injecting it into the circumgalactic medium.
A geometric probe of cosmology – II. Gravitational lensing time delays and quasar reverberation mapping revisited
Authors: Ng Angela L H 
Published: May 2023

ABSTRACT
The time delay between images of strongly gravitationally lensed quasars is an established cosmological probe. Its limitations, however, include uncertainties in the assumed mass distribution of the lens. We re-examine the methodology of a prior work presenting a geometric probe of cosmology independent of the lensing potential, which considers differential time delays over images originating from spatially separated photometric signals within a strongly lensed quasar. We give an analytic description of the effect of differential lensing on the emission line spectral flux for axisymmetric broad line region geometries, with the inclined ring or disc, spherical shell, and double cone as examples. The proposed method is unable to recover cosmological information as the observed time delay and inferred line-of-sight velocity do not uniquely map to the three-dimensional position within the source.
Dynamics of Gene Loss following Ancient Whole-Genome Duplication in the CrypticParameciumComplex
Authors: Gout Jean-Francois , Hao Yue , Johri Parul , Arnaiz Olivier , Doak Thomas G , Bhullar Simran , Couloux Arnaud , Guérin Fréderic , Malinsky Sophie , Potekhin Alexey , Sawka Natalia , Sperling Linda , Labadie Karine , Meyer Eric , Duharcourt Sandra , Lynch Michael 
Published: May 2023

AbstractWhole-genome duplications (WGDs) have shaped the gene repertoire of many eukaryotic lineages. The redundancy created by WGDs typically results in a phase of massive gene loss. However, some WGD–derived paralogs are maintained over long evolutionary periods, and the relative contributions of different selective pressures to their maintenance are still debated. Previous studies have revealed a history of three successive WGDs in the lineage of the ciliate Paramecium tetraurelia and two of its sister species from the Paramecium aurelia complex. Here, we report the genome sequence and analysis of 10 additional P. aurelia species and 1 additional out group, revealing aspects of post-WGD evolution in 13 species sharing a common ancestral WGD. Contrary to the morphological radiation of vertebrates that putatively followed two WGD events, members of the cryptic P. aurelia complex have remained morphologically indistinguishable after hundreds of millions of years. Biases in gene retention compatible with dosage constraints appear to play a major role opposing post-WGD gene loss across all 13 species. In addition, post-WGD gene loss has been slower in Paramecium than in other species having experienced genome duplication, suggesting that the selective pressures against post-WGD gene loss are especially strong in Paramecium. A near complete lack of recent single-gene duplications in Paramecium provides additional evidence for strong selective pressures against gene dosage changes. This exceptional data set of 13 species sharing an ancestral WGD and 2 closely related out group species will be a useful resource for future studies on Paramecium as a major model organism in the evolutionary cell biology.
Pancreatic Enzyme Replacement and Nutritional Support With n﻿ab-Paclitaxel-based First-Line Chemotherapy Regimens in Metastatic Pancreatic Cancer
Authors: Giordano Guido , Cincione Raffaele Ivan , Losavio Francesca , Senia Tiziano , Aquilini Mummolo Arianna , Pacilli Mario , Lizzi Vincenzo , Bruno Giuseppina , Piscazzi Annamaria , Conteduca Vincenza , Landriscina Matteo 
Published: May 2023

Abstract

Background
At diagnosis, more than 80% of patients with pancreatic cancer (PC) suffer from significant weight loss due to malnutrition which is a major concern for patient management, and this may negatively impact treatment outcomes and patient prognosis.

Patients and Methods
We performed an observational, retrospective study on patients with metastatic PC (mPC) undergoing first-line chemotherapy with nab-Paclitaxel containing schedules and receiving or not receiving nutritional support (NS) and pancreatic enzyme replacement therapy (PERT) to investigate their relevance in this setting.

Results
We observed that PERT and ancillary dietary interventions are related to longer overall survival (OS; median: 16.5 vs. 7.5 months, P &lt; .001) and have a significant, independent, prognostic impact for better outcomes (P = .013), independently from the therapeutic regimen. Furthermore, PERT and NS prevented weight loss during chemotherapy and obtained an improvement of nutritional parameters such as phase angle and free-fat mass index, after 3 months of anticancer treatment. Consistently, the positive impact on OS correlated also with the prevention of Karnofsky performance status deterioration and a lower incidence of maldigestion-related symptoms.

Conclusions
Our data suggest that an early and well-conducted NS in patients with mPC may impact on survival and preserve performance status, thus improving quality of life.
Incidence and Risk Factors for Pneumonitis Associated With Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: A Single Center Experience
Authors: Altan Mehmet , Soto Felipe , Zhong Linda L , Akhmedzhanov Fechukwu O , Wilson Nathaniel R , Zarifa Abdulrazzak , Albittar Aya A , Yang Vincent , Lewis Jeff , Rinsurongkawong Waree , Jack Lee J , Rinsurongkawong Vadeerat , Zhang Jianjun , Gibbons Don L , Vaporciyan Ara A , Jennings Kristofer , Khawaja Fareed , Faiz Saadia A , Shannon Vickie R , Shroff Girish , Godoy Myrna C B , Daver Naval G , Gandhi Saumil , Mendoza Tito R , Naing Aung , Daniel-MacDougall Carrie , Heymach John V , Sheshadri Ajay 
Published: May 2023

Abstract

Introduction
Immune checkpoint inhibitor (ICI) pneumonitis causes substantial morbidity and mortality. Estimates of real-world incidence and reported risk factors vary substantially.

Methods
We conducted a retrospective review of 419 patients with advanced non-small cell lung cancer (NSCLC) who were treated with anti-PD-(L)1 with or without anti-CTLA-4 therapy. Clinical, imaging, and microbiological data were evaluated by multidisciplinary adjudication teams. The primary outcome of interest was grade ≥2 (CTCAEv5) pneumonitis. Clinicopathologic variables, tobacco use, cancer therapies, and preexisting lung disease were assessed for univariate effects using Cox proportional hazards models. We created multivariate Cox proportional hazards models to assess risk factors for pneumonitis and mortality. Pneumonitis, pneumonia, and progression were modeled as time-dependent variables in mortality models.

Results
We evaluated 419 patients between 2013 and 2021. The cumulative incidence of pneumonitis was 9.5% (40/419). In a multivariate model, pneumonitis increased the risk for mortality (HR 1.6, 95% CI, 1.0-2.5), after adjustment for disease progression (HR 1.6, 95% CI, 1.4-1.8) and baseline shortness of breath (HR 1.5, 95% CI, 1.2-2.0). Incomplete resolution was more common with more severe pneumonitis. Interstitial lung disease was associated with higher risk for pneumonitis (HR 5.4, 95% CI, 1.1-26.6), particularly in never smokers (HR 26.9, 95% CI, 2.8-259.0).

Conclusion
Pneumonitis occurred at a high rate and significantly increased mortality. Interstitial lung disease, particularly in never smokers, increased the risk for pneumonitis.
New results on the two low-mass-ratio overcontact binaries V1309 Herculis and AS Coronae Borealis
Authors: Matekov Azizbek , Meng Fangbin , Qian Shengbang , Asfandiyarov Ildar , Li Linjia , Ehgamberdiev Shuhrat , Zhu Liying 
Published: May 2023

Abstract
We present new multi-color light curves of V1309 Her and AS CrB, which were observed by the 60 cm telescope located at the Maidanak Astronomical Observatory. Combined with the Large-Sky-Area Multi-Object Fiber Spectroscopic Telescope atmospheric parameters, we analyzed our BVRCIC light curves for both systems by employing the Wilson–Devinney program. Our results show that both systems are low-mass-ratio overcontact binaries (V1309 Her: q = 0.213, AS CrB: q = 0.16). AS CrB has a high fill-out factor, while that of V1309 Her is moderate. By adding our new times of minimum light, we found the periodic oscillations in their O − C curves, which could be explained by the light travel-time effect of the third bodies. The third lights detected during the light curve analysis support the existence of the third bodies in V1309 Her and AS CrB. Third bodies usually play an important role for the origin and evolution of the central pair by removing their angular momentum. With the angular momentum loss, a moderate-fill-out overcontact binary like V1309 Her will evolve to a deep one like AS CrB. AS CrB lies at the late evolutionary stage of contact binaries. A long-term period increase at a rate of dP/dt = 5.22(± 0.28) × 10−7 d yr−1 was detected in our O − C diagram analysis. When its orbital angular momentum is less than three times the total spin angular momentum, a system may finally evolve into a rapid-rotating single star.
Resilience in patients with complex regional pain syndrome 1—a cross-sectional analysis of patients participating in a cross-sectional cohort study
Authors: Wertli Maria Monika , Aegler Barbara , McCabe Candida S , Grieve Sharon , Llewellyn Alison , Schneider Stephanie , Bachmann Lucas M , Brunner Florian 
Published: May 2023

Abstract

Objective
To assess the degree of resilience in patients with complex regional pain syndrome (CRPS) 1, to explore the relationship between resilience and patient-related outcome measurements and to describe a pattern of clinical manifestations associated with low resilience.

Methods
This study presents a cross-sectional analysis of baseline information collected from patients enrolled in a single center study between February 2019 and June 2021. Participants were recruited from the outpatient clinic of the Department of Physical Medicine & Rheumatology of the Balgrist University Hospital, Zurich, Switzerland. We used linear regression analysis to explore association of resilience with patient reported outcomes at baseline. Furthermore, we explored the impact of significant variables on the low degree resilience using logistic regression analysis.

Results
Seventy-one patients (females 90.1%, mean age 51.2 ± 12.9 years) were enrolled. There was no association between CRPS severity and the level of resilience. Quality of Life was positively correlated with resilience, as was pain self-efficacy. Pain catastrophizing was inversely correlated with the level of resilience. We observed a significant inverse association between anxiety, depression and fatigue and the level of resilience. The proportion of patients with a low resilience increased with higher level of anxiety, depression and fatigue on the PROMIS-29, without reaching statistical significance.

Conclusion
Resilience seems to be an independent factor in CRPS 1 and is associated with relevant parameters of the condition. Therefore, caretakers may screen the current resilience status of CRPS 1 patients to offer a supplementary treatment approach. Whether specific resilience training modifies CRPS 1 course, requires further investigations.
3D-printed GelMA/CaSiO3 composite hydrogel scaffold for vascularized adipose tissue restoration
Authors: Zhang Jupei , Zeng Zhen , Chen Yanxin , Deng Li , Zhang Yanxin , Que Yumei , Jiao Yiren , Chang Jiang , Dong Zhihong , Yang Chen 
Published: May 2023

Abstract
The increased number of mastectomies, combined with rising patient expectations for cosmetic and psychosocial outcomes, has necessitated the use of adipose tissue restoration techniques. However, the therapeutic effect of current clinical strategies is not satisfying due to the high demand of personalized customization and the timely vascularization in the process of adipose regeneration. Here, a composite hydrogel scaffold was prepared by three-dimensional (3D) printing technology, applying gelatin methacrylate anhydride (GelMA) as printing ink and calcium silicate (CS) bioceramic as an active ingredient for breast adipose tissue regeneration. The in vitro experiments showed that the composite hydrogel scaffolds could not only be customized with controllable architectures, but also significantly stimulated both 3T3-L1 preadipocytes and human umbilical vein endothelial cells in multiple cell behaviors, including cell adhesion, proliferation, migration and differentiation. Moreover, the composite scaffold promoted vascularized adipose tissue restoration under the skin of nude mice in vivo. These findings suggest that 3D-printed GelMA/CS composite scaffolds might be a good candidate for adipose tissue engineering.
Shocked by Bank Funding Shocks: Evidence from Consumer Credit Cards
Authors: Chava Sudheer , Ganduri Rohan , Paradkar Nikhil , Zeng Linghang 
Published: May 2023

Abstract
Using the near universe of U.S. consumer credit cards, we show that banks transmit their wholesale funding shocks to consumers by reducing their credit card limits. Credit-constrained consumers who are unable to hedge against the transmitted shock by accessing other credit cards experience a stronger and more persistent reduction in aggregate credit card limits at the consumer level. Consequently, these credit-constrained consumers reduce their aggregate credit card borrowing. Our results document a credit card lending channel for the transmission of adverse bank shocks and show who bears the costs of fragile bank funding structures.
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Quantitative measurement of motor activity during sleep in isolated REM sleep behavior disorder patients using actigraphy before and after treatment with clonazepam
Authors: Park Kyoungeun , Shin Yong Woo , Hwang Sungeun , Jeong El , Kim Tae-Joon , Jun Jin-Sun , Shin Jung-Won , Byun Jung-Ick , Sunwoo Jun-Sang , Kim Han-Joon , Schenck Carlos H , Jung Ki-Young 
Published: May 2023

Abstract

Study Objectives
We conducted a prospective study to quantify motor activity during sleep measured by actigraphy before and after 3 months of treatment with clonazepam in patients with video-polysomnography (vPSG) confirmed isolated rapid eye movement (REM) sleep behavior disorder (iRBD).

Methods
The motor activity amount (MAA) and the motor activity block (MAB) during sleep were obtained from actigraphy. Then, we compared quantitative actigraphic measures with the results of the REM sleep behavior disorder questionnaire for the previous 3-month period (RBDQ-3M) and of the Clinical Global Impression-Improvement scale (CGI-I), and analyzed correlations between baseline vPSG measures and actigraphic measures.

Results
Twenty-three iRBD patients were included in the study. After medication treatment, large activity MAA dropped in 39% of patients, and the number of MABs decreased in 30% of patients when applying 50% reduction criteria. 52% of patients showed more than 50% improvement in either one. On the other hand, 43% of patients answered “much or very much improved” on the CGI-I, and RBDQ-3M was reduced by more than half in 35% of patients. However, there was no significant association between the subjective and objective measures. Phasic submental muscle activity during REM sleep was highly correlated with small activity MAA (Spearman’s rho = 0.78, p &lt; .001) while proximal and axial movements during REM sleep correlated with large activity MAA (rho = 0.47, p = .030 for proximal movements, rho = 0.47, p = .032 for axial movements).

Conclusions
Our findings imply that quantifying motor activity during sleep using actigraphy can objectively assess therapeutic response in drug trials in patients with iRBD.
PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate–Activated Protein Kinase Activation
Authors: Fu Caihua , Yu Shengbo , Liu Zhiquan , Wang Jiayu , Liu Ping , Su Guohai 
Published: May 2023

Abstract
Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate–activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway.
Double-Docking Technique for Femtosecond Laser-Assisted Deep Anterior Lamellar Keratoplasty: A Retrospective Consecutive Case Series Study of Advanced Keratoconus
Authors: Gabison Eric E. , Gree Eva , Azar Georges , Cochereau Isabelle , Guindolet Damien 
Published: May 2023

Purpose:
The aim of this study was to report the clinical outcomes and prognosis of femtosecond laser (FSL)-assisted double-docking deep anterior lamellar keratoplasty (DD-DALK) for advanced keratoconus (AK).

Methods:
Records of consecutive patients with keratoconus who underwent FSL-assisted DALK (DD-DALK) were reviewed.

Results:
We analyzed 37 eyes from 37 patients who underwent DD-DALK. Sixty-eight percent of eyes had a successful big-bubble formation and 27% had a manual dissection to achieve the DALK deep dissection. Stromal scarring was associated with not achieving a big bubble. Intraoperative conversion to penetrating keratoplasty was conducted in 2 cases (5%). The best-corrected visual acuity improved from a median (± interquartile range) of 1.55 ±0.25 logMAR preoperatively to 0.2 ±0.2 logMAR (P < 0.0001). The median postoperative spherical equivalent was −5.75 ±2.75 D with a median astigmatism of −3.5 ±1.3 D. BCVA, SE, and astigmatism were not statistically different between patients who underwent DD-DALK and patients who underwent manual DALK. Stromal scarring was associated with big-bubble (BB) formation failure (P = 0.003). All patients with failed BB requiring manual dissection had anterior stromal scarring.

Conclusions:
DD-DALK is safe and reproducible. The success rate of BB formation is hampered by stromal scarring.
IDO Regulates Macrophage Functions by Inhibiting the CCL2/CCR2 Signaling Pathway in Fungal Keratitis
Authors: Yu Feifei , Jiang Wei , Zhang Li , Jiang Nan 
Published: May 2023

Purpose:
The aim of this study was to investigate the effects of indoleamine 2,3-dioxygenase (IDO) on macrophage polarization, phagocytosis, and killing through regulation of the CCL2/CCR2 signaling pathway in Aspergillus fumigatus keratitis.

Methods:
In vivo and in vitro experiments were conducted in mice and mouse peritoneal macrophages after infection with A. fumigatus. Clinical scoring, reverse transcription–polymerase chain reaction, and immunofluorescence staining were used to evaluate the fungal keratitis lesions, macrophage-related cytokines, and macrophage recruitment. The expression of CCL2 and CCR2 was detected by reverse transcription–polymerase chain reaction and western blot after pretreatment with or without an IDO inhibitor (1-MT). After pretreatment with 1-MT, a CCR2 antagonist, a CCL2 neutralizing antibody, an IDO agonist (IFNG), and recombinant CCL2 protein (CCL2), the flow cytometry and colony-forming unit counts were used to detect the polarization, phagocytosis, and killing function.

Results:
Compared with the control group, the infected eyes showed increased clinical scores, macrophage-related cytokine expression, and macrophage recruitment. 1-MT pretreatment increased the expression of CCL2 and CCR2 and the proportion of CD206+/CD86+ macrophages; macrophages polarized toward the M2 type, with enhanced killing function. CCR2 antagonists and CCL2 neutralizing antibodies reversed the effects of 1-MT. Compared with the infected group, IFNG pretreatment decreased the proportion of CD206+/CD86+ macrophages, and macrophages polarized toward the M1 type, with decreased phagocytosis and impaired killing function. CCL2 reversed the effect of IFNG.

Conclusions:
IDO can promote the polarization of macrophages to the M1 type by blocking the CCL2/CCR2 signaling pathway, inhibiting the phagocytosis and killing function of macrophages, and mediating the protective immune role of A. fumigatus.