bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criminological Aspects of Residivis in use Narcotics
Authors: Daud Magfirah Rahmalia 
Published: August 2023

The purpose of this study is to find out and analyze the criminological factors behind recidivists in narcotics use in Gorontalo Province and to find out how. The type of research used is empirical research, using primary and secondary data sources. Using data clotting techniques with observation methods, interview methods, and documentation methods. Then the data is analyzed descriptively or provides an overview or exposure to the subject and object of study as the results of the research carried out. The results showed criminological factors behind recidivist use in narcotics use in Gorontalo Province when viewed from the Differentia Associationtheory, namely environmental/social factors causing a person to commit criminal acts repeatedly. The bad stigma that arises from the society of ex-convicts makes these ex-convicts feel excluded explained based on label theory, imitation theory is the result of imitation of crimes that occur in their environment, self-defense theory is health caused by weak self-defense against their poor environment as drug users, Criminoloids theory of crimes caused by lust.
Criminal Sanctions for Persecution Resulting in Serious Injury
Authors: Yasin Fandaria Putri , M. Wantu Fence 
Published: August 2023

This study aims to find out and analyze how to prove the verdict of a criminal offense that results in serious injury based on the title raised in this authorship. An author is a type of writer an Emperis law or a field writer. With a Case approach. The process of collecting data from regulations and other references related to the problem being studied. The results of this author show that the proof of the Determination of the criminal act of assault resulting in serious injury is said to be incorrect but if we refer to the court decision of the defendant/convicted person is proven to have committed a criminal act of assault resulting in serious injury, but is only sentenced to imprisonment for six (6) months. The judge’s role in determining the criminal act of assault resulting in serious injury is influenced by two counts, namely the judge's estimate that lawfully and convincingly committed the crime of persecution and the legal act used in the indictment article is more than Article 351 Paragraph 2 of the Criminal Code of persecution resulting in serious injury.
Causing Factors Crimes Against the Circulation of Counterfeit Money
Authors: Kau Rahmat M 
Published: August 2023

This study aims to determine the factors causing crimes against the circulation of counterfeit money. The method used in this study is an empirical legal research methodology and uses a qualitative approach to descriptive qualitative analysis techniques. The results of this study show that the factors causing crimes against the circulation of counterfeit money include economic factors, self-benefit factors, low education factors and factors of opportunities to commit crimes, environmental factors, and technological factors. In preventing the crime of circulating counterfeit banknotes in the city of Gorontalo, in this case, the police must strictly enforce and play an active role if they receive complaints from the community. The police must be able to take precautions before the perpetrators or individuals who play the opportunity circulate counterfeit money.
Causes and Efforts to Counter a Crime
Authors: Firmansyah Isa Muh. 
Published: August 2023

This study aims to determine the causes and countermeasures against a crime. The method used in this study, namely the research methodology used, is empirical research and uses a descriptive qualitative approach and qualitative analysis techniques. The results of this study show that the causes and efforts to overcome a crime there are several causes of the crime that occurs due to the talent of the perpetrator, the environment, the spiritual, and the economy. Crimes range from mild to the most serious forms such as severe mistreatment that cause severe injuries to their victims so that physical and non-physical problems arise. But it is also necessary to realize that, the person who committed the crime is a person like us. Crimes or criminal acts must be dealt with because they create discomfort and insecurity in people's lives, so they can do rational ways of dealing with them. Meanwhile, efforts made to tackle the crime include penal efforts and repressive efforts.
Legal Consequences of Marriage During Iddah Period Based on Compilation Islamic Law
Authors: Pomahiya Sinta , M. Kasim Nur , Alhasni Bakung Dolot 
Published: August 2023

Abstract: This journal discusses marriage during the Iddah period. In Article 2 of the Compilation of Islamic Law, it is stated that marriage according to Islamic law is marriage, which is a very strong mistaken gholiidhan contract to obey Allah's commands. However, not all Islamic teachings can be implemented properly. This is evidenced by the existence of couples who do not care about iddah issues. Carrying out iddah for women is considered a form of worship. The type of research used types of sociological research, which aims-describes the implementation of marriage during the Iddah period and the legal consequences of marriage during the Iddah period. The results of the study’s three main points can be concluded. First, the implementation of marriage during the iddah period is the same as marriage in general, it's just that the marriage is carried out during the iddah period so the marriage is invalid. Second, because the marriage law during the iddah period will arise, the husband and wife will not get a marriage certificate, and when the marriage takes place there will be hereditary problems. Keywords: Marriage; Iddah; Islamic Law Compilation
Prosecutor's Review of Unlicensed Drug Trafficking Prosecution
Authors: Apriliyani Yulinda , Achir Nuvazria 
Published: August 2023

The purpose of this research is to know and analyze about what is the impact of drug users without a permit at the Bone Bolango State Attorney. The type of research used is empirical research, using data types consisting of primary data and secondary data. Data collection techniques were carried out using interviews, observation, and documentation techniques. The results of the study show that the prosecutor's considerations in imposing criminal charges against the perpetrators in drug distribution cases without a license include objective and subjective considerations. To achieve legal certainty and the purpose of sentencing the accused. The impact of drug distribution without a permit in the Bone Bolango Region is that it is very disturbing to the community and also endangers physical, mental, and social health conditions.
Cultural Heritage Zoning System of Otanaha Fort Gorontalo City: Its Implementation in Regional Regulations
Authors: Muliadi Andi 
Published: August 2023

The purpose of this study is to determine and analyze the implementation of the zoning system in the cultural heritage of Fort Otanaha in Gorontalo Province. This research uses a type of normative-empirical (applied) research, which is research that examines the implementation or implementation of positive legal provisions (legislation) and written documents in action (factual) on a certain legal event that occurs in society. Based on the results of the study, it was concluded that in the application of the zoning system in accordance with the mandate of applicable laws and regulations, it is necessary to have a legal umbrella, namely a derivative regulation that can become a legal umbrella and become an extension to realize the mandate stated in the Cultural Heritage Law so that the cultural heritage of Fort Otanaha can be preserved and passed down from generation to generation.
Legal Protection for Victims of Domestic Violence
Authors: Sarjono Sarjono 
Published: August 2023

The purpose of this research is to find out what is becomingfactors causing violence against women in the household as well as legal protection efforts for victims of violence against women in the household in the Kusambi Police Region, West Muna Regency. The research method used is Empirical. Legal protection efforts that can be given to victims of domestic violence in the Kusambi Police area from the perspective of police victimology in minimizing the incidence of victims of domestic violence in the Kusambi Police area are carried out using a preventive approach, which is a follow-up effort from pre-emptive efforts. which provides counseling and outreach to the community. Meanwhile, repressive efforts are by way of law enforcement against perpetrators of domestic violence in accordance with applicable punishments. ConclusionFrom the point of view of critical victimology, the main factors that cause violence against women contain three points, namely in terms of substance, constraints by law enforcement officials, and the legal culture of society. Forms of legal protection that can be given to victims of domestic violence in the Kusambi Police area from a victimological perspectivenamely preventive efforts andrepressive.
Comparing the effects of corn fermented protein with traditional distillers dried grains fed to healthy adult dogs on stool quality, nutrient digestibility, and palatability
Authors: Kilburn-Kappeler Logan R. , Lema Almeida Krystina A. , Paulk Chad B. , Aldrich Charles G. 
Published: August 2023

Traditional distillers dried grains, co-products from the ethanol industry, can be utilized as sustainable ingredients for pet food. However, negative consumer perception prevents their widespread use. Corn fermented protein (CFP) is produced using post-fermentation separation technology, resulting in a high protein ingredient, which may increase consumer appeal compared to traditional distillers dried grains. The study objective was to compare the effect of CFP with that of traditional distillers dried grains on stool quality, nutrient digestibility, and palatability when fed to dogs. The control diet (CON) contained 15% soybean meal and the experimental diets contained 3.5% brewer’s dried yeast (BDY), 2.5% brewer’s dried yeast plus 17.5% distillers dried grains with solubles (BDY+DDGS), or 17.5% corn fermented protein (CFP). Experimental diets were fed to adult dogs (n = 12) in a 4 × 4 replicated Latin square design. Dogs were adapted to the diets for 9 days; this was followed by 5 days of total fecal collection. Titanium dioxide (0.4%) was added to all diets as an external marker to estimate digestibility. Data were analyzed using a mixed model in SAS, with treatment as a fixed effect and dog and period as random effects. Fecal output was greatest (p&lt; 0.05) for dogs fed BDY+DDGS. The feces of dogs consuming CFP were firmer (p&lt; 0.05) than those of dogs consuming CON and BDY+DDGS. Overall, nutrient digestibility was greatest (p&lt; 0.05) for CON and BDY and lowest for BDY+DDGS, with that for CFP being intermediate. There were no differences (p&gt; 0.05) in total short-chain or branched-chain fatty acid concentrations in the fresh fecal samples of dogs fed these dietary treatments. However, the percentage of propionate was higher (p&lt; 0.05) in the fecal samples of dogs fed CON than in those of dogs fed BDY+DDGS, whereas the percentage of valerate was higher (p&lt; 0.05) in the fecal samples of dogs fed CON than in those of dogs fed CFP. In the palatability evaluation, dogs had no preference when CON was compared with BDY or BDY+DDGS. However, dogs appeared to prefer CON over CFP. Overall, CFP resulted in improved stool quality and nutrient digestibility when compared with DDGS, which could increase consumer appeal for inclusion into pet food. The impact of CFP on palatability, however, warrants further investigation.
Characterizing host-pathogen interactions between Zostera marina and Labyrinthula zosterae
Authors: Venkataraman Yaamini R. , Shore Amanda , Dayal Sukanya , Lee James Sanghyun , Alidoost Salimi Mahsa , Crandall Grace , Loeher Malina M. , Stoops Mark , Swanger Megan , Eisenlord Morgan E. , Van Alstyne Kathryn L. , Fast Mark D. , Burge Colleen A. , Groner Maya L. 
Published: August 2023

IntroductionSeagrass meadows serve as an integral component of coastal ecosystems but are declining rapidly due to numerous anthropogenic stressors including climate change. Eelgrass wasting disease, caused by opportunistic Labyrinthula spp., is an increasing concern with rising seawater temperature. To better understand the host-pathogen interaction, we paired whole organism physiological assays with dual transcriptomic analysis of the infected host and parasite. MethodsEelgrass (Zostera marina) shoots were placed in one of two temperature treatments, 11° C or 18° C, acclimated for 10 days, and exposed to a waterborne inoculation containing infectious Labyrinthula zosterae (Lz) or sterile seawater. At two- and five-days post-exposure, pathogen load, visible disease signs, whole leaf phenolic content, and both host- and pathogen- transcriptomes were characterized. ResultsTwo days after exposure, more than 90% of plants had visible lesions and Lz DNA was detectable in 100% percent of sampled plants in the Lz exposed treatment. Concentrations of total phenolic compounds were lower after 5 days of combined exposure to warmer temperatures and Lz, but were unaffected in other treatments. Concentrations of condensed tannins were not affected by Lz or temperature, and did not change over time. Analysis of the eelgrass transcriptome revealed 540 differentially expressed genes in response to Lz exposure, but not temperature. Lz-exposed plants had gene expression patterns consistent with increased defense responses through altered regulation of phytohormone biosynthesis, stress response, and immune function pathways. Analysis of the pathogen transcriptome revealed up-regulation of genes potentially involved in breakdown of host defense, chemotaxis, phagocytosis, and metabolism. DiscussionThe lack of a significant temperature signal was unexpected but suggests a more pronounced physiological response to Lz infection as compared to temperature. Pre-acclimation of eelgrass plants to the temperature treatments may have contributed to the limited physiological responses to temperature. Collectively, these data characterize a widespread physiological response to pathogen attack and demonstrate the value of paired transcriptomics to understand infections in a host-pathogen system.
Toll-like receptor 4 and Syk kinase shape dendritic cell-induced immune activation to major house dust mite allergens
Authors: Busold Stefanie , Akkerdaas Jaap H. , Zijlstra-Willems Esther M. , van der Graaf Kees , Tas Sander W. , de Jong Esther C. , van Ree Ronald , Geijtenbeek Teunis B. H. 
Published: August 2023

BackgroundHouse dust mite (HDM) is a major cause of respiratory allergic diseases. Dendritic cells (DCs) play a central role in orchestrating adaptive allergic immune responses. However, it remains unclear how DCs become activated by HDM. Biochemical functions of the major HDM allergens Der p 1 (cysteine protease) and Der p 2 (MD2-mimick) have been implicated to contribute to DC activation.MethodsWe investigated the immune activating potential of HDM extract and its major allergens Der p 1 and Der p 2 using monocyte-derived DCs (moDCs). Maturation and activation markers were monitored by flow cytometry and cytokine production by ELISA. Allergen depletion and proteinase K digestion were used to investigate the involvement of proteins, and in particular of the major allergens. Inhibitors of spleen tyrosine kinase (Syk), Toll-like receptor 4 (TLR4) and of C-type lectin receptors (CLRs) were used to identify the involved receptors. The contribution of endotoxins in moDC activation was assessed by their removal from HDM extract.ResultsHDM extract induced DC maturation and cytokine responses in contrast to the natural purified major allergens Der p 1 and Der p 2. Proteinase K digestion and removal of Der p 1 or Der p 2 did not alter the immune stimulatory capacity of HDM extract. Antibodies against the CLRs Dectin-1, Dectin-2, and DC-SIGN did not affect cytokine responses. In contrast, Syk inhibition partially reduced IL-6, IL-12 and completely blocked IL-10. Blocking TLR4 signaling reduced the HDM-induced IL-10 and IL-12p70 induction, but not IL-6, while endotoxin removal potently abolished the induced cytokine response.ConclusionOur data strongly suggest that HDM-induced DC activation is neither dependent on Der p 1 nor Der p 2, but depend on Syk and TLR4 activation, which might suggest a crosstalk between Syk and TLR4 pathways. Our data highlight that endotoxins play a potent role in immune responses targeting HDM.
Prevalence, predictors, dynamic bone change, and treatment efficacy of osteoporosis among chronic obstructive pulmonary disease patients: a prospective cohort study
Authors: Kaenmuang Punchalee , Keeratichananont Warangkana , Geater Sarayut Lucien , Chantamanee Nicha , Srikaew Piyaporn 
Published: August 2023

BackgroundOsteoporosis is a silent chronic obstructive pulmonary disease (COPD) comorbidity that is often under-detected. We aimed to study the prevalence and potential predictors of osteoporosis in COPD. Dynamic changes in bone mass density (BMD) and treatment efficacy of bisphosphonate were also assessed.MethodsThis prospective cohort study included COPD patients between January 2017 and January 2019. Demographics data, spirometric parameters, and C-reactive protein (CRP) were collected. Bone mineral density (BMD) at the lumbar spine (L2-4) and both femoral necks were measured after enrollment and the 12-month follow-up. Participants were categorized into three groups per the baseline BMD T-score: normal (≥ − 1.0), osteopenia (between −1.0 and − 2.5), and osteoporosis (≤ − 2.5). In the osteoporosis group, alendronate 70 mg/week with vitamin D and calcium was prescribed.ResultsIn total, 108 COPD patients were enrolled. The prevalence of osteoporosis and osteopenia were 31.5 and 32.4%, respectively. Advanced age, lower body mass index (BMI), history of exacerbation in the previous year, and high CRP levels were significant predictors of osteoporosis. After 12 months, 35.3% in the osteoporosis group reported new vertebral and femoral fractures, compared to none in the non-osteoporosis group (p &lt; 0.001). In the normal BMD and osteopenia groups showed a further decline in BMD after 12-month. Conversely, the osteoporosis group showed a statistically significant improvement in BMD after anti-resorptive treatment (p &lt; 0.001).ConclusionThe prevalence of osteoporosis was high in Thai COPD patients. Advanced age, lower BMI, history of exacerbation, and high CRP levels were potential predictors. A rapid decline in BMD was observed in COPD patients without treatment.
Construction of a cuproptosis-associated lncRNA prognostic signature for bladder cancer and experimental validation of cuproptosis-related lncRNA UBE2Q1-AS1
Authors: Shen Junlin , Du Mingyang , Liang Shuang , Wang Linhui , Bi Jianbin 
Published: August 2023

IntroductionBladder cancer (BLCA) is the ninth most common malignancy worldwide and the fourth most common cancer in men. Copper levels are significantly altered in patients with thyroid, breast, lung, cervical, ovarian, pancreatic, oral, gastric, bladder, and prostate cancers. Outcomes can be predicted by constructing signatures using lncRNA-related genes associated with outcomes.MethodsWe identified lncRNAs related to outcomes, those differentially expressed in bladder cancer, and cuproptosis-related lncRNAs from TCGA. We identified the intersection to obtain 12 genes and established a prognostic risk signature consisting of eight genes using LASSO-penalized multivariate Cox analysis. We constructed a training set, performed survival analysis on the high-and low-risk groups, and performed validation in the test and full sets. There existed a substantial contrast in the likelihood of survival among the cohorts of high and low risk. An in-depth analysis of the gene mutations associated with tumors was conducted to evaluate the risk of developing cancer. We also performed gene analysis on neoadjuvant chemotherapy. We conducted experimental validation on the key gene UBE2Q1-AS1 in our prognostic signature.ResultsThe risk signature we constructed shows significant differences between the high-risk group and the low-risk group. Univariate survival analysis of the eight genes in our signature showed that each gene distinguished between high- and low-risk groups. Sub-group analysis revealed that our risk score differed significantly in tumor stage, age, and gender. The analysis results of the tumor mutation burden (TMB) showed a significant difference in the TMB between the low- and high-risk groups, which had a direct impact on the outcomes. These findings highlight the importance of TMB as a potential prognostic marker in cancer detection and prevention. We analyzed the immune microenvironment and found significant differences in immune function, validation responses, immunotherapy-related positive markers, and critical steps in the tumor immunity cycle between the high- and low-risk groups. We found that the effect of anti-CTLA4 and PD-1 was higher in the high-risk group than in the low-risk group.Gene analysis of neoadjuvant chemotherapy revealed that the treatment effect in the high-risk group was better than in the low-risk group. The key gene UBE2Q1-AS1 in our prognostic signature can significantly influence the cell viability, migration, and proliferation of cancer cells.DiscussionWe established a signature consisting of eight genes constructed from cuproptosis-related lncRNAs that have potential clinical applications for outcomes prediction, diagnosis, and treatment.