bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and recovery of anterior cruciate ligament rupture combined with posterolateral tibial plateau fracture in the East China population: a 2-year follow-up study
Authors: Jiang Shijie , Ren Weizhi , Zhao Gongyin , Zhu Ruixia , Jia Xiaojun , Zheng Dong , Wang Yuji , Xu Wei 
Published: July 2023

Abstract
Objective: This study aimed to describe the incidence of ACL ruptures combined with posterolateral tibial plateau fractures in the East China population and evaluate the clinical outcomes of ACL reconstruction without treatment for posterolateral tibial plateau fracture at a 2-year follow-up.
Methods: Based on the inclusion criteria, the study included patients with ACL rupture or ACL avulsion fracture. MRI scans were reviewed to determine the incidence of ACL rupture combined with posterolateral tibial plateau fracture and concomitant injury. Clinical outcomes were evaluated using the SF-12 scale, the IKDC Subjective Knee Assessment Scale, the Lysholm Knee Rating Scale, the Tegner Activity Level Scale, and the KOOS score at a 2-year follow-up.
Results: 488 cases were enrolled, with 74.6% having noncontact injury mechanisms. Fractures with higher severity had a higher rate of meniscus damage, and patients with high-grade subtypes of fractures had a higher incidence of MCL tears than patients with low-grade fracture types. The Lysholm scores of the high-grade subtypes were 85.45 and 86.37, and the postoperative Tegner scores of the high-grade subtypes were 5.5. There were significant differences in functional recovery between patients with high-grade subtypes and patients with low-grade tibial plateau fractures.
Conclusions: The study found a high prevalence of displaced posterolateral tibial plateau impaction fractures in the setting of ACL tears, and they can be classified into distinct morphologic subtypes. The functional recovery of patients with high-grade subtypes of fractures is significantly lower than that of patients with low-grade injuries, suggesting that patients with high-grade injuries need surgical treatment to obtain satisfactory treatment results.
A Metallurgical Technology Investigation of the Wangxiangping Ancient Smelting Sites at Daye County
Authors: Pang Shuo , Li Chenyuan , Li Yanxiang 
Published: July 2023

Abstract
During the spring of 2022, an archaeo-metallurgical survey was conducted by the Beijing University of Science and Technology at the Wangxiangping site in Daye County. This subsequent testing excavation uncovered pottery and metal smelting relics from the Shang and Zhou dynasties. Charcoal samples extracted from the third stratification can be dated using 14C to as early as the late Shang Dynasty. The SEM-EDS method was employed to analyze the metallurgical relics found in each stratification layer of the site. The analysis revealed that pure copper smelting and tin bronze smelting activities coexisted at this location. Research results suggest that secondary copper oxide ore was used for reduction smelting, resulting in the production of red copper and high-grade 'white' matte. Additionally, tin ore was incorporated to create bronze, with tin serving as the alloy composition. However, no residual artifacts from casting activities were discovered. The survey and detection analysis conducted at this site offer significant evidence and data supporting further research into copper smelting activities in the Daye area during the Shang and Zhou dynasties.
A strong direct link from the layer 3/4 border to layer 6 of cat primary visual cortex
Authors: Martin Kevan A.C. , Sägesser Franziska D. 
Published: July 2023

Abstract

The cat primary visual cortex (V1) is a cortical area for which we have one of the most detailed estimates of the connection 'weights' (expressed as number of synapses) between different neural populations in different layers (Binzegger et al. 2004). Nevertheless, the majority of excitatory input sources to layer 6, the deepest layer in a local translaminar excitatory feedforward loop, was not accounted for by the known neuron types used to generate the quantitative Binzegger diagram. We aimed to fill this gap by using a retrograde tracer that would label neural cell bodies in and outside V1 that directly connect to layer 6 of V1.
We found that more than 80 % of labeled neurons projecting to layer 6 were within V1 itself. Our data indicate that a substantial fraction of the missing input is provided by a previously unidentified population of layer 3/4 border neurons, laterally distributed and connecting more strongly to layer 6 than the typical superficial layer pyramidal neurons considered by Binzegger and colleagues (2004).
This layer 3/4 to layer 6 connection may be a parallel route to the layer 3 – layer 5 – layer 6 feedforward pathway, be associated with the fast-conducting, movement-related Y pathway and provide convergent input from distant (5–10 degrees) regions of the visual field.
Financial Impact of Medication Reviews by Clinical Pharmacists to Reduce In-Hospital Adverse Drug Events: A Return-on-Investment Analysis
Authors: Jermini Mégane , Fonzo-Christe Caroline , Blondon Katherine , Milaire Christelle , Stirnemann Jérôme , Bonnabry Pascal , Guignard Bertrand 
Published: July 2023

Abstract
Backgrounds: Adverse drug events (ADEs) contribute to rising healthcare costs. Clinical pharmacists can reduce the risks of ADEs by preventing medication errors (MEs) through drug therapy optimization.
Aim: To build an economic model to reveal whether clinical pharmacists’ medication review (MR) activities were compensated by a reduction in healthcare costs associated with the prevention of potential ADEs.
Method: Pharmacists performed MR by solving drug-related problems (DRPs) to prevent ADEs during ward rounds in an internal medicine setting. First, avoided costs were estimated by monetizing five categories of DRPs (improper drug selection, drug interactions, untreated indications, inadequate dosages, and drug use without an indication). An expert panel assessed potential ADEs and their probabilities of occurrence for 20 randomly selected DRPs in each category. The costs of ADEs were extracted from internal hospital financial data. Second, a partial economic study in a hospital perspective, estimated the annual costs avoided through ADE prevention and the return on investment (ROI) of MR.
Results: The estimated annual cost avoided of the potential ADEs resulting from 676 DRPs detected was € 304,170. The cost of a 0.9 full-time equivalent (FTE) clinical pharmacist was € 112,408. Extrapolated to 1 FTE, the net saving per annum was € 213,069 or an ROI of 1 to 1.71. Sensitivity analyses showed the robustness of the economic model.
Conclusion: This economic model enabled to show the positive financial impact and favourable ROI of a MR intervention performed by clinical pharmacists. It should encourage the future deployment of a pharmacist-led ADE-prevention program.
LncRNA-mediated TPI1 and PKM2 promote self-renewal and chemoresistance in GBM
Authors: Yang Changxiao , Li Ziwei , Meng Xiangqi , Wang Xinyu , Song Dan , Xu Tianye , Tian Kaifu , Sun Penggang , Zhong Junzhe , Song Yu , Ma Wenbin , Liu Yuxiang , Yu Daohan , Shen Ruofei , Jiang Chuanlu , Cai Jinquan 
Published: July 2023

AbstractBackground Temozolomide (TMZ) resistance is one of the major reasons for the poor prognosis of glioblastoma patients. Long noncoding RNAs (lncRNAs) are widely involved in multiple biological processes, including TMZ resistance. We previously showed that Linc00942 is a potential regulator of TMZ sensitivity in glioblastoma (GBM) cells. However, the underlying mechanism of TMZ resistance induced by Linc00942 is unknown. Methods We performed a rapid amplification of cDNA ends (RACE) assay in TMZ-resistant GBM cells to confirm the sequence of Linc00942. ChIRP-MS and ChIRP-WB assays showed that Linc00492 interacted with TPI1 and PKM2. Molecular docking analysis, RNA pull-down, and RIP assays were used to demonstrate the underlying mechanisms of Linc00942 binding with TPI1 and PKM2. Native PAGE was used to identify the polymers of TPI1 and PKM2. The efficiency of Linc00942-mediated TMZ resistance was detected in vitro and in vivo. Results In this study, we identified the sequence of Linc00942, and further experiments confirmed that Linc00942 contributes to self-renewal and TMZ resistance in GBM cells. Linc00942 interacts with TPI1 and PKM2, subsequently promoting the phosphorylation, dimerization, and nuclear translocation of both proteins. The interaction of Linc00942 with TPI1 and PKM2 leads to increased acetylation of H3K4 and activation of the STAT3/P300 axis, resulting in the marked transcriptional activation of SOX9. Moreover, knockdown of SOX9 reversed the TMZ resistance induced by Linc00492 both in vitro and in vivo. Conclusions Linc00942 strongly promotes SOX9 by interacting with TPI1 and PKM2, thereby driving self-renewal and TMZ resistance in GBM cells. These findings provide potential combined therapeutic strategies to overcome TMZ resistance in GBM.
A queueing simulation method for evaluating the performance of resource management in mutual mode
Authors: Akuamoah Worlanyo Saviour , Ayimah John Coker , Mahama Francois , Bonsi Prosper Obed , Yaro David 
Published: July 2023

Abstract
We model a queueing resource management in mutual mode. When analyzing the performance of the service system, we often use the queueing theory to get the various performance indexes. As the number of resources in the service system with interactive mode increases due to users' sharing behavior, it becomes very difficult to get a steady state of the system. We investigate how to evaluate the performance of such a service system in which the amount of resources changes over time on accounts of users' sharing behavior. In the process of solving, an algorithm is designed to evaluate the convergence of performance indicators. The algorithm effectiveness is verified by the simulation test of the evaluation system and the simulation frequency range of convergence of service performance indicators. We compare the queueing process in the mutual mode to the non-mutual mode and then obtain a steady state for the mutual mode. The unique phenomenon in interactive mode, which is a performance inflection point, is found which has a guiding significance for efficient production.
Influence of Weight-Functions on the Performance of Element-Free Galerkin Method
Authors: Nagevadiya Bhumik , Bhoraniya Rameshkumar 
Published: July 2023

Abstract
The influence of the weight functions on the performance of the element-free Galerkin method has been studied. The convergence and computational cost using various functions for 1D and 2D structural models are examined. Acceptable ranges, as well as the best scaling parameters for each weight function, are pointed out. Mesh-free methods are completely independent of mesh and approximate the governing partial differential equations based on the only set of nodes. We have discussed the analysis of six different weight functions using the physical nature of field problems and show that the continuity of mesh-free shape function i.e., moving least square shape function depends on weight function. It is observed that the so-called weight function which is showing a minimum error is not always true. The convergence & computational cost (computation time) are also important factors. The manuscript contains the solution of 1D and 2D elastostatic problems with ten different weight functions. Paper represents the comparative study of different weight functions to predict the best field behavior with systematic analysis of each case.
Properties of High Volume GGBS based Concrete with Carbonation Curing
Authors: Debbarma Aravinda 
Published: July 2023

Abstract
Manufacturing of portland cement is an energy-intensive process and releases a large amount of greenhouse gases into the atmosphere, which affects the earth’s ecosystem. Efforts are being carried out to conserve energy by means of promoting the use of industrial wastes like Ground Granulated Blast Furnace Slag (GGBS), silica fumes, flyash, etc., which show chemical properties similar to cement. Replacement with industrial waste products like GGBS, flyash, silica fume, etc. which are having pozzolanic property same as cement will help to reduce the rate of cement consumption. This study evaluates the mechanical properties of concrete with Ground Granulated Blast-furnace Slag (GGBS). In the GGBS based concrete, cement was replaced with GGBS ranging from 60% to 80% and the specimens were cured with water/CO2 gas curing. Carbon Dioxide gas curing is an advanced curing process for cementitious material that provides strength at an early stage of the curing process, also known as an accelerated curing technique. Concrete when combined with Carbon Dioxide gas as a curing agent under specified temperature, pressure and duration gives an early strength at a short period of curing time. The curing of the concrete specimens was performed with water for 28 days/CO2 gas for 6 and 12 hours. The addition of CO2 as a curing agent for the concrete specimens also results in the production of more ettringite and C-S-H gel in the concrete. It also shows a huge amount of calcium hydroxide and the C-S-H hydration product under Scanning Electron Microscope (SEM) images. This study reveals that curing with CO2 gas gives better compressive and flexural strength at an early age for concrete mix with high volume GGBS than ordinary cement concrete.
Performance Evaluation of UHPFRC Plates subjected to Low-velocity Impact Loading
Authors: Mishra Suruchi , Sharma H. K. 
Published: July 2023

Abstract
In the present study, an attempt has been made to study the behavior of ultra-high performance fiber reinforced concrete (UHPFRC) plate specimens under impact loading analytically using the ANSYS V20.R2 explicit dynamics software. In this regard, UHPFRC plate specimens with sizes 500 × 500 × 50 mm were modeled and analyzed using a 5.25 kg impactor with a 500 mm drop height. The typical results of analytical investigations have been analyzed and discussed to study the behavior of UHPFRC plate specimens in light of the stress-strain behavior, deformation-time behavior, acceleration-time behavior, energy absorption capacity, failure characteristics, etc. The analytical results are compared with the experimental results for 4-side and 2-side simply supported (SS). It has been observed that experimental and analytical values are in good agreement regarding stress, strain, deformation, acceleration, energy absorption capacity, and failure characteristics. However, the variation in analytical and experimental values was because several pieces of equipment and accessories were used in the experimental investigation. Additionally, it has also been noticed that adding fibers reduces UHPFRC plates' deflection and acceleration while increasing the energy absorption capacity and stress and strain values for fiber content corresponding to 8%. However, increasing the deformation capacity of the plates by adding large quantities of fibers in the case of low-velocity impact is not very beneficial. The addition of MSF in UHPFC enhances the stiffness as well as strength of the composites. As the number of supported sides increased, the deflection and acceleration values decreased significantly.
Practical Approach to Strengthening of Pre-Engineered Building for Additional Futuristic Load using Mild Steel (MS) Section
Authors: Patil Pratik m. Patil Pratik m. , Patil Savita N. Patil Savita N. , Desai Piyush P. Desai Piyush P. 
Published: July 2023

Abstract
Technological advancements have greatly aided in improving the quality of life through a variety of new products and services. Pre-Engineered Building (PEB) is among such technological advancements in structural engineering. Pre-engineered buildings (PEB) are nothing but steel buildings in which excess steel is avoided by tapering the sections as per the bending moment’s requirement. Now the day’s PEB industrial sector is developing very fast, & its growth has increased widely after some years Electricity is very essential for the PEB industrial sector that’s why every PEB industry uses solar power energy through the installation of solar panels on or above the industry rooftop of existing PEB industrial structures. But at that time need to strengthen the existing PEB industrial structure while the industry is in working condition. This paper reviews the analysis and design of existing PEB industrial structures with and without added solar panels load (futuristic load) to them, which have been carried out using STAAD. Pro software & find out the member strengthening requirement base on the STADD Pro results like Bending moment & stress. Two different techniques are currently used to increase or restore the load-carrying capacity of PEB structures: 1) Bonding FRP sheets and 2) welding mild steel plates. Strengthening by mild steel plate is a popular method due to its availability, cheapness, uniform materials properties (isotropic), ease of work, high ductility, and high fatigue strength. This paper suggests various/ different Techniques or sections are used for strengthening existing PEB industrial structures using mild steel sections/ plate (MS). These techniques are Practically possible, economical, optimum, & suitable for the strengthening of existing PEB structures. which are very important to improve the load-carrying capacity of steel structures while adding solar panels load to them. This paper uses Mild steel (MS) Plate welding in different locations/patterns as per the strengthening requirement and will be carried out using STADD Pro & ANSYS Software.
Nonlinear relationships between built environmental characteristics and ridership in Xi'an metrostation
Authors: Xi Yafei , Hou Quanhua , Duan Yaqiong , Lei Kexin , Wu Yan , Cheng Qianyu 
Published: July 2023

Abstract
In recent years, Xi'an metro construction has been progressing rapidly, becoming the primary mode of urban green public transportation. Since the ridership of the metro is closely linked to the characteristics of its surrounding built environment, a key problem in promoting the benign development between the two is to explore the spatiotemporal distributional difference in ridership and its influencing factors. In this study, the "5D" characteristics of built environment are described by density, diversity, design, destination and distance variables. The spatiotemporal distribution characteristics of ridership are analyzed via Arc GIS and Python, while the nonlinear relationships between ridership and built environment of 106 metro stations of downtown Xi'an, as well as relevant threshold effects are revealed via Shapley additive explanations  with gradient boosted decision tree (GBDT-SHAP). The results show that: (1) Xi'an metro travel presents a medium-short spatiotemporal distribution, and the ridership network is characterized by strong center-spillover. (2) The nonlinear relationship between built environment and ridership is ubiquitous and presents a threshold effect. The impact threshold of bus stop density on ridership is 4-6 pcs/km2, the impact threshold of road network density is roughly 4-5 km/km2, and the effective threshold of building density does not exceed 20%. (3) The positive impact of POI facility density on peak ridership is stronger than that at flat hours. Variables like land use mixture, population density and distance from downtown have a time-driven effect on the ridership, whose importance and influence change with time. This study provides a better understanding of the spatiotemporal impact of Xi'an's built environment on metro travel, which is of profound significance for the coordinated development between the city and metro construction.
Temporal and spatial dynamics of pesticide use in three field vegetable crops with respect to sowing date and degree days
Authors: Räsänen Kati , Kaseva Janne , Aaltonen Marja , Vänninen Irene 
Published: July 2023

Abstract
We analyzed the timing of pesticide treatments for eventual analysis of temporal environmental risks associated with pesticide use in field vegetable crops. We also investigated the extent to which timing of treatments reflected predicted flight times of pests to gain an understanding of whether farmers followed the model predictions in their decision-making as part of Integrated Pest Management (IPM). The data cover chemical plant protection in field vegetable farms in southwestern Finland in 2009–2019.
The timing of treatments, made with different pesticides in the weeks following sowing, corresponded with the known phenology of different pests of the three crops. The same was true for the carrot fly, the pea moth and the 2nd generation of the cabbage root fly when phenological models using historical data were used to predict the timing of treatments. Carrot psyllids, root flies and pea moths were the most targeted insects in carrot, swede and peas, respectively. Spray frequencies against carrot psyllid increased over time for carrot. The use of insecticides was least for fresh pea.
We conclude that farmers acted in accordance with the principles of IPM when practising chemical control. For those species that lacked phenological predictive models in the study years, the degree days for the observed timing of treatments can be used as a starting point if such models are developed in the future. Our results can be used as a long-term baseline in future surveys on the changes in pesticide use and their risks regarding the studied crops.
Exploring the Place Dynamics of Roadside Space Conflicts with Street View Images: The Case of Beijing
Authors: Dang Anrong , Li Xiangyu , Chen Maini 
Published: July 2023

Abstract
Conflicts between vehicles, cyclists, and pedestrians have been increasingly investigated as automobiles marginalize other types of mobility in crowded public spaces, particularly in roadside spaces where active mobility meets automobiles. These conflicts are extremely visible in Beijing, one of the world's most congested cities. This study explores the fined-grained spatial patterns of roadside space conflicts and factors associated with two types of conflicts (vehicle-bike, and vehicle-pedestrian). A systematic method combining spatial sampling and machine learning is described to capture the frequency of conflicts between vehicles, cyclists, and pedestrians from street view images. The ridge regression analysis identifies places with a higher probability of generating roadside space conflicts and disparate dynamics between urban and suburban/rural communities. The results of the analysis are compared with the current street regeneration plan in Beijing, which suggests that future plans should incorporate place-based roadside space management strategies in addition to the provision of on-street parking facilities.