bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of systematicity in early referent selection
Authors: Sia Ming Yean , Mather Emily , Crocker Matthew W. , Mani Nivedita 
Published: September 2023

AbstractPrevious studies showed that word learning is affected by children's existing knowledge. For instance, knowledge of semantic category aids word learning, whereas a dense phonological neighbourhood impedes learning of similar‐sounding words. Here, we examined to what extent children associate similar‐sounding words (e.g., rat and cat) with objects of the same semantic category (e.g., both are animals), that is, to what extent children assume meaning overlap given form overlap between two words. We tested this by first presenting children (N = 93, Mage = 22.4 months) with novel word‐object associations. Then, we examined the extent to which children assume that a similar sounding novel label, that is, a phonological neighbour, refers to a similar looking object, that is, a likely semantic neighbour, as opposed to a dissimilar looking object. Were children to preferentially fixate the similar‐looking novel object, it would suggest that systematic word form‐meaning relations aid referent selection in young children. While we did not find any evidence for such word form‐meaning systematicity, we demonstrated that children showed robust learning for the trained novel word‐object associations, and were able to discriminate between similar‐sounding labels and also similar‐looking objects. Thus, we argue that unlike iconicity which appears early in vocabulary development, we find no evidence for systematicity in early referent selection.
Attention and motor profiles in children with developmental coordination disorder: A neuropsychological and neuroimaging investigation
Authors: Bonthrone Alexandra F. , Green Dido , Morgan Angela T. , Mankad Kshitij , Clark Christopher A. , Liégeois Frédérique J. 
Published: September 2023

AbstractAimThis study aimed to (1) quantify attention and executive functioning in children with developmental coordination disorder (DCD), (2) assess whether some children with DCD are more likely to show attention difficulties, and (3) characterize brain correlates of motor and attention deficits.MethodFifty‐three children (36 with DCD and 17 without) aged 8 to 10 years underwent T1‐weighted and diffusion‐weighted magnetic resonance imaging, and standardized attention and motor assessments. Parents completed questionnaires of executive functioning and symptoms of inattention and hyperactivity. We assessed regional cortical thickness and surface area, and cerebellar, callosal, and primary motor tract structure.ResultsAnalyses of covariance and one‐sample t‐tests identified impaired attention, non‐motor processing speed, and executive functioning in children with DCD, yet partial Spearman's rank correlation coefficients revealed these were unrelated to one another or the type or severity of the motor deficit. Robust regression analyses revealed that cortical morphology in the posterior cingulate was associated with both gross motor skills and inattentive symptoms in children with DCD, while gross motor skills were also associated with left corticospinal tract (CST) morphology.InterpretationChildren with DCD may benefit from routine attention and hyperactivity assessments. Alterations in the posterior cingulate and CST may be linked to impaired forward modelling during movements in children with DCD. Overall, alterations in these regions may explain the high rate of non‐motor impairments in children with DCD.What this paper adds

Children with developmental coordination disorder have difficulties in attention, processing speed, and executive functioning.
Non‐motor impairments were not interrelated or correlated with the type or severity of motor deficit.
Posterior cingulate morphology was associated with gross motor skills and inattention.
Gross motor skills were also associated with left corticospinal tract morphology.
Pre‐play promises, threats and commitments under partial credibility
Authors: Melkonyan Tigran , Chakravarty Surajeet 
Published: September 2023

AbstractThe paper examines how pre‐play communication between players with partial credibility affects the ensuing strategic interaction. We consider an environment where players are uncertain about the economic and psychological costs of reneging on promises but learn these at the time of their implementation. We demonstrate that in the equilibrium both players make promises. The latter are partially effective in terms of achieving collusive outcomes and improving the players' payoffs under strategic complementarity, where promises are used to signal future collusive behavior. In contrast, under strategic substitutability the ability to make a promise can be used to signal future aggressive behavior and one of the players may even get a lower expected (before the type is revealed) payoff than in the game without communication.
First report of Ceratocystis fimbriata causing wilt on Gmelina arborea in Costa Rica
Authors: Méndez‐Álvarez Dawa , de Souza Cândido Tonimara , Couto Alfenas Acelino , Murillo Olman , Badilla Yorleny , Ferreira Alfenas Rafael 
Published: September 2023

AbstractIncreased diseases outbreaks in Gmelina arborea (melina) are a threat to sustainability of commercial plantations. One main disease, known as 'melina sudden death', limits the growth and development of trees, causing losses of up to 40% in commercial plantation. However, the main cause of this disease was unknown, until now. Proof of Ceratocystis fimbriata as the aetiological agent of 'melina sudden death' is provided based on field records of disease symptoms, histopathological observation of infected tissue, morphological features of the fungus, maximum‐likelihood phylogenetic inference of the ITS rDNA sequences and pathogenicity test conducted on GENFORES elite melina genotypes. Thus, the appropriate name for the disease should be Ceratocystis wilt. As far as we know, this is the first report of Ceratocystis wilt in melina caused by Ceratocystis fimbriata in Central America. This disease represents a serious threat to Costa Rica's forest industry, as well as in other Latin American countries.
Decay fungi associated with cavity excavation by a large South American woodpecker
Authors: Pozzi Carla , Rajchenberg Mario , Ojeda Valeria 
Published: September 2023

AbstractIn temperate systems of the Northern Hemisphere, wood‐decay fungi are known to facilitate cavity excavation by woodpeckers. For South America, woodpecker–fungi interactions have not been explored. The aim of this work was to identify wood‐decay fungi associated with the process of cavity excavation by the Magellanic woodpecker (Campephilus magellanicus), a large South American picid that excavates on living trees. The survey was conducted in old‐growth Nothofagus pumilio forests of Patagonia. For freshly excavated cavities, wood condition was assessed, adjacent basidiocarps were collected, and fungal cultures were obtained from wood samples taken to the laboratory. All cavities exhibited softened wood. Four Agaricomycotina were isolated in cultures: Stereum hirsutum was the most frequent, followed by Postia pelliculosa, Nothophellinus andinopatagonicus and Aurantiporus albidus. Basidiocarps around cavities were of two species that did not develop in cultures: Laetiporus portentosus and Macrohyporia dictyopora. Excavations were slightly more frequent in white rot colonized than brown rot colonized wood, but this may be an artefact of differential success in fungal isolation and culturing, since several cavities that showed visual symptoms of brown wood rots did not yield mycelia of those wood‐decay fungi. As shown by research elsewhere, basidiocarps underestimated heart rot on cavity walls and revealed additional wood‐decay species living on the same trees; therefore, assessments of fungal diversity in substrates used for cavity excavation should be based on culturing and/or DNA extraction. Because fungal communities in the southern Andes are poorly known, decay fungi and their roles in ecosystem development should be studied across different forest areas, where samples from non‐cavity‐bearing (control) trees should also be taken in order to determine excavation‐site selection.
A computational model of current control mechanism for long‐term potentiation (LTP) in human episodic memory based on gene–gene interaction
Authors: Tripathi Sudhakar , Mishra Ravi Bhushan , Bihari Anand , Agrawal Sanjay , Joshi Puneet 
Published: September 2023

AbstractThe establishment of long‐term potentiation (LTP) is a prime process for the formation of episodic memory. During the establishment of LTP, activations of various components are required in the signaling cascade of the LTP pathway. Past efforts to determine the activation of components relied extensively on the cellular or molecular level. In this paper, we have proposed a computational model based on gene‐level cascading and interaction in LTP signaling for the establishment and control of current signals for achieving the desired level of activation in the formation of episodic memory. This paper also introduces a model for a generalized signaling pathway in episodic memory. A back‐propagation feedback mechanism is used for updating the interaction levels in the signaling cascade starting from the last stage and ending at the start stage of the signaling cascade. Simulation of the proposed model has been performed for the LTP signaling pathway in the context of human episodic memory. We found through simulation that the qualifying genes correction factors of all stages are updated to their maximum limit. The article explains the signaling pathway for episodic memory and proves its effectiveness through simulation results.
Dopaminergic neuronal death via necroptosis in Parkinson's disease: A review of the literature
Authors: Regoni Maria , Valtorta Flavia , Sassone Jenny 
Published: September 2023

AbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by progressive dysfunction and loss of dopaminergic neurons of the substantia nigra pars compacta (SNc). Several pathways of programmed cell death are likely to play a role in dopaminergic neuron death, such as apoptosis, necrosis, pyroptosis and ferroptosis, as well as cell death associated with proteasomal and mitochondrial dysfunction. A better understanding of the molecular mechanisms underlying dopaminergic neuron death could inform the design of drugs that promote neuron survival.Necroptosis is a recently characterized regulated cell death mechanism that exhibits morphological features common to both apoptosis and necrosis. It requires activation of an intracellular pathway involving receptor‐interacting protein 1 kinase (RIP1 kinase, RIPK1), receptor‐interacting protein 3 kinase (RIP3 kinase, RIPK3) and mixed lineage kinase domain‐like pseudokinase (MLKL). The potential involvement of this programmed cell death pathway in the pathogenesis of PD has been studied by analysing biomarkers for necroptosis, such as the levels and oligomerization of phosphorylated RIPK3 (pRIPK3) and phosphorylated MLKL (pMLKL), in several PD preclinical models and in PD human tissue. Although there is evidence that other types of cell death also have a role in DA neuron death, most studies support the hypothesis that this cell death mechanism is activated in PD tissues. Drugs that prevent or reduce necroptosis may provide neuroprotection for PD. In this review, we summarize the findings from these studies. We also discuss how manipulating necroptosis might open a novel therapeutic approach to reduce neuronal degeneration in PD.
Hepatic steatosis in people older and younger than fifty who are living with HIV and HIV‐negative controls: A cross‐sectional study nested within the POPPY cohort
Authors: Arenas‐Pinto Alejandro , Bakewell Nicholas , Milinkovic Ana , Williams Ian , Vera Jaime , Post Frank A. , Anderson Jane , Beynon Michelle , O'Brien Alastair , Doyle Nicki , Gilson Richard , Pett Sarah L. , Winston Alan , Sabin Caroline A. ,   the Pharmacokinetic and clinical Observations in People over fiftY [POPPY]) study
Published: September 2023

AbstractBackgroundHepatic steatosis is a major cause of chronic liver disease associated with several negative health outcomes. We compared the prevalence of and factors associated with steatosis in people living with and without HIV.MethodsOlder (>50 years) and younger (<50 years) people with HIV and older HIV‐negative controls (>50 years) underwent liver transient elastography examination with controlled attenuation parameter (steatosis ≥238 dB/m, moderate/severe steatosis ≥280 dB/m, liver fibrosis ≥7.1 kPa). We compared groups using logistic regression/Chi‐squared/Fisher's exact/Kruskal–Wallis tests.ResultsIn total, 317 participants (109 older people with HIV; 101 younger people with HIV; 107 HIV‐negative controls) were predominantly white (86%) and male (76%), and 21% were living with obesity (body mass index ≥30 kg/m2). Most (97%) people with HIV had undetectable HIV RNA. The prevalence of fibrosis was 8.4%, 3.0%, and 6.5% in the three groups, respectively (p = 0.26). Fibrosis was predominately (>65%) mild. The prevalence of steatosis was the same in older people with HIV (66.4%) and controls (66.4%) but lower in younger people with HIV (37.4%; p < 0.001). After adjustment, younger people with HIV were less likely to have steatosis (odds ratio [OR] 0.26; 95% confidence interval [CI] 0.14–0.52) than controls, but male sex (OR 2.45; 95% CI 1.20–4.50) and high waist‐to‐hip ratio (OR 3.04; 95% CI 1.74–5.33) were associated with an increased odds of steatosis. We found no association between steatosis and HIV‐related variables.ConclusionsThe prevalence of hepatic steatosis and fibrosis was similar between older participants regardless of HIV status. Age, sex, and abdominal obesity, but not HIV‐related variables, were associated with steatosis. Interventions for controlling obesity should be integrated into routine HIV care.
Type I interferon and cancer
Authors: Holicek Peter , Guilbaud Emma , Klapp Vanessa , Truxova Iva , Spisek Radek , Galluzzi Lorenzo , Fucikova Jitka 
Published: September 2023

SummaryType I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at least some) malignant cells, but also their pronounced immunostimulatory functions. In line with this notion, type I IFN signaling has been implicated in the antineoplastic effects of various immunogenic therapeutics, including (but not limited to) immunogenic cell death (ICD)‐inducing agents and immune checkpoint inhibitors (ICIs). On the other hand, weak, indolent, and non‐resolving type I IFN responses have been demonstrated to support tumor progression and resistance to therapy, reflecting the ability of suboptimal type I IFN signaling to mediate cytoprotective activity, promote stemness, favor tolerance to chromosomal instability, and facilitate the establishment of an immunologically exhausted tumor microenvironment. Here, we review fundamental aspects of type I IFN signaling and their context‐dependent impact on malignant transformation, tumor progression, and response to therapy.
Short‐term fix or remedy for market failure? Immigration policy as a distinct source of skills
Authors: Wright Chris F. , McLaughlin Colm 
Published: September 2023

AbstractThis article analyses the role of immigration policy as a distinct source of skills supply in liberal market economies. It draws upon interviews with representatives of employer associations and trade unions in the Australian construction and hospitality industries to identify how labour market actors make sense of the function of immigration policy. Rather than ‘complementing’ or ‘undermining’ training and other domestic labour market institutions, as is often assumed, immigration policy can serve to remedy the systemic failures of these institutions to supply skills in the short term. However, overreliance on immigration can disincentivise reform of the labour market institutions necessary to generate adequate skills supply in the long term. The findings suggest the need to reconceptualise the function of immigration policy in terms of its distinct rather than equivalent functions to labour market institutions.
Integrating factors associated with complex wound healing into a mobile application: Findings from a cohort study
Authors: Marques Raquel , de Lopes Marcos Venícios Oliveira , Neves‐Amado João Daniel , Ramos Paulo Alexandre Silva , de Sá Luís Octávio , da Oliveira Irene Maria Silva , da Amado João Manuel Costa , de Vasconcelos Maria João Medeiros , Salgado Pedro Miguel Faria , Alves Paulo Jorge Pereira 
Published: September 2023

AbstractComplex, chronic or hard‐to‐heal wounds are a prevalent health problem worldwide, with significant physical, psychological and social consequences. This study aims to identify factors associated with the healing process of these wounds and develop a mobile application for wound care that incorporates these factors. A prospective multicentre cohort study was conducted in nine health units in Portugal, involving data collection through a mobile application by nurses from April to October 2022. The study followed 46 patients with 57 wounds for up to 5 weeks, conducting six evaluations. Healing time was the main outcome measure, analysed using the Mann–Whitney test and three Cox regression models to calculate risk ratios. The study sample comprised various wound types, with pressure ulcers being the most common (61.4%), followed by venous leg ulcers (17.5%) and diabetic foot ulcers (8.8%). Factors that were found to impair the wound healing process included chronic kidney disease (U = 13.50; p = 0.046), obesity (U = 18.0; p = 0.021), non‐adherence to treatment (U = 1.0; p = 0.029) and interference of the wound with daily routines (U = 11.0; p = 0.028). Risk factors for delayed healing over time were identified as bone involvement (RR 3.91; p < 0.001), presence of odour (RR 3.36; p = 0.007), presence of neuropathy (RR 2.49; p = 0.002), use of anti‐inflammatory drugs (RR 2.45; p = 0.011), stalled wound (RR 2.26; p = 0.022), greater width (RR 2.03; p = 0.002), greater depth (RR 1.72; p = 0.036) and a high score on the healing scale (RR 1.21; p = 0.001). Integrating the identified risk factors for delayed healing into the assessment of patients and incorporating them into a mobile application can enhance decision‐making in wound care.
Development and validation of a nomogram for arterial stiffness
Authors: Wang Tingjun , Cai Xiaoqi , Zhang Lingyu , Yang Ting , Ye Chaoyi , Xu Guoyan , Xie Liangdi 
Published: September 2023

AbstractEven though as a gold standard for noninvasive measurement of arterial stiffness, carotid‐femoral pulse wave velocity (cfPWV) is not widely used in primary healthcare institutions due to time‐consuming and unavailable equipment. The aim of this study was to develop a convenient and low‐cost nomogram model for arterial stiffness screening. A cross‐sectional study was undertaken in the department of general practice, the First Affiliated Hospital of Fujian Medical University. Arterial stiffness was defined as cfPWV ≥ 10 m/s. A total of 2717 participants were recruited to construct the nomogram using the least absolute shrinkage and selection operator and logistic regressions. Receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis, clinical impact curve were used to evaluate the performance of the model. The model was validated internally and externally (399 participants) by bootstrap method. Arterial stiffness was identified in 913 participants (33.60%). Age, sex, waist to hip ratio, systolic blood pressure, duration of diabetes, heart rate were selected to construct the nomogram model. Good discrimination and accuracy were exhibited with area under curve of 0.820 (95% CI 0.803–0.837) in ROC curve and mean absolute error = 0.005 in calibration curve. A positive net benefit was shown in decision curve analysis and clinical impact curve. A satisfactory agreement was displayed in internal validation and external validation. The low cost and user‐friendly nomogram is suitable for arterial stiffness screening in primary healthcare institutions.
Translating the nuanced risk for substance use among adolescents treated for attention‐deficit/hyperactivity disorder (ADHD) into clinical practice: a commentary on McCabe et al. (2023)
Authors: Kennedy Traci M. , Molina Brooke S. G. 
Published: September 2023

In their recent examination of the Monitoring the Future (MTF) data, McCabe et al. (Journal of Child Psychology and Psychiatry, 2023) address the complex, longstanding, and clinically valuable questions of whether and how stimulant medication treatment for adolescents with ADHD relates to their risk for substance use. Here, we expand on the authors' interpretations of their nuanced findings of increased risk for illicit stimulant use and non‐prescribed stimulant medication use for youth with later age of medication treatment initiation and shorter treatment duration. We particularly focus on highlighting tangible clinical implications, and we recommend ways future research can build on the authors' findings to further clarify this important issue.
Keyword network analysis of changes in the image of nurses pre‐ and post‐COVID‐19 in the media environment
Authors: Kim Doo Ree , Lee Gi Ran 
Published: September 2023

AbstractAims and objectivesTo analyse and describe the changes in the image of nurses perceived by the public pre‐ and post‐COVID‐19 in Korea.BackgroundNurses play an important role in disaster situations such as COVID‐19. In such disaster situations, we aim to confirm the image of nurses projected in the mass media and promote the professionalism of nurses through the image of nurses as professionals.DesignQualitative media keyword networks analysis.MethodsTo understand the change in the image of nurses pre‐ and post‐COVID‐19, the big data program TEXTOM was used to collect data. From 19 January to 31 May 2020, data were set as ‘post‐COVID‐19’, and 1 year before 18 January 2020, data were set as ‘pre‐COVID‐19’. The keywords from 9533 articles were refined, frequency analysed and social networks analysed using TEXTOM and MS office excel, and the analysis results were visualised using UCINET 6 and the NetDraw program.ResultsAs for keywords related to nurses pre‐COVID‐19, those with the most frequent appearance and the highest networking degree in centrality were ‘work’, ‘older adults’, ‘care’, ‘time’, ‘care worker’, ‘caring labor’. As for keywords related to nurses post‐COVID‐19, those that appeared most often and had the highest degree of centrality networking were ‘COVID‐19’, ‘USA’, ‘China’, ‘check’, ‘patient’, ‘work’.ConclusionThis study shows that the public image of nurses has changed more positively after COVID‐19 due to the media. Individual nurses and nursing organizations should pay attention to the deficiency in the image of nurses and provide a way to reform the public image of professional nurses.Relevance to clinical practiceThe effects of global crises such as COVID‐19 on nurses were confirmed, and information delivered through the media was an important way to improve the nursing profession.