bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the effects of continuous veno-venous hemodiafiltration on O2 and CO2 removal and energy expenditure measurement using indirect calorimetry
Authors: Wasyluk Weronika , Fiut Robert , Czop Marcin , Zwolak Agnieszka , Dąbrowski Wojciech , Malbrain Manu L N G , Jonckheer Joop 
Published: January 2025

Abstract

Background
Continuous veno-venous hemodiafiltration (CVVHDF) is used in critically ill patients, but its impact on O₂ and CO₂ removal, as well as the accuracy of resting energy expenditure (REE) measurement using indirect calorimetry (IC) remains unclear. This study aims to evaluate the effects of CVVHDF on O₂ and CO₂ removal and the accuracy of REE measurement using IC in patients undergoing continuous renal replacement therapy.

Design
Prospective, observational, single-center study.

Methodology
Patients with sepsis undergoing CVVHDF had CO₂ flow (QCO₂) and O₂ flow (QO₂) measured at multiple sampling points before and after the filter. REE was calculated using the Weir equation based on V̇CO₂ and V̇O₂ measured by IC, using true V̇CO₂ accounting for the CRRT balance, and estimated using the Harris-Benedict equation. The respiratory quotient (RQ), the ratio of V̇CO₂ to V̇O₂, was evaluated by comparing measured and true values.

Results
The mean QCO₂ levels measured upstream of the filter were 76.26 ± 17.33 ml/min and significantly decreased to 62.12 ± 13.64 ml/min downstream of the filter (p < 0.0001). The mean QO₂ levels remained relatively unchanged. The mean true REE was 1774.28 ± 438.20 kcal/day, significantly different from both the measured REE of 1758.59 ± 434.06 kcal/day (p = 0.0029) and the estimated REE of 1619.36 ± 295.46 kcal/day (p = 0.0475). The mean measured RQ value was 0.693 ± 0.118, while the mean true RQ value was 0.731 ± 0.121, with a significant difference (p < 0.0001).

Conclusions
CVVHDF may significantly alter QCO₂ levels without affecting QO₂, influencing the REE and RQ results measured by IC. However, the impact on REE is not clinically significant, and the REE value obtained via IC is closer to the true REE than that estimated using the Harris-Benedict equation. Further studies are recommended to confirm these findings.

Graphical Abstract
Seasonal coastal residency and large-scale migration of two grey mullet species in temperate European waters
Authors: Edwards Jena E. , Buijse Anthonie D. , Winter Hendrik V. , Bijleveld Allert I. 
Published: January 2025

AbstractGrey mullets (family Mugilidae) are widespread across coastal, brackish, and freshwater habitats, and have supported fisheries for millennia. Despite their global distribution and commercial value, little is known about their movement ecology and its role in the co-existence of sympatric mullet species. Gaps in knowledge about migratory behaviour, seasonal occurrence, and movement scales have also impeded effective management, highlighting the need for further research. This study aimed to identify key habitats and timing of grey mullet presence across the Dutch Wadden Sea, North Sea, and freshwater areas, and to explore potential behavioral differences between two grey mullet species: thicklip mullet (Chelon labrosus) and thinlip mullet (Chelon ramada). Using acoustic telemetry, we tracked 86 tagged grey mullet over three years (thicklip mullet, N = 74; thinlip mullet, N = 12), combining data from 100 local acoustic receivers and the European Tracking Network. Both species were detected in the Wadden Sea from April to November, however, thinlip mullet arrived in the Wadden Sea earlier than thicklip mullet (median date = May 16 vs. June 7). Individual residency in the Wadden Sea lasted a median 97 days for thicklip mullet and 94 days for thinlip mullet. Thinlip mullet were also detected by more receivers and over a larger area than thicklip mullet, indicating differences in movement behaviour. Both species showed an affinity for receivers near major harbours, with thinlip mullet more often detected near fresh water outflows. Seasonal migrations between coastal and offshore waters were also observed, with one thinlip mullet returning to freshwater across consecutive years. North Sea detections spanned ten months, with a gap during the presumed spawning period (Jan–Feb). Our data suggest that thinlip mullet show a preference for deeper gullies while thicklip mullet may spend more time in shallow areas and flooded tidal flats. These findings highlight the importance of the Wadden Sea as a seasonal foraging ground and provide insights into the migratory patterns of grey mullets.
Personalising glioblastoma medicine: explant organoid applications, challenges and future perspectives
Authors: Skarne Niclas , D’Souza Rochelle C. J. , Palethorpe Helen M. , Bradbrook Kylah A. , Gomez Guillermo A. , Day Bryan W. 
Published: January 2025

AbstractGlioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor prognosis and a dismal five-year survival rate. Despite significant knowledge gains in tumour biology, meaningful advances in patient survival remain elusive. The field of neuro-oncology faces many disease obstacles, one being the paucity of faithful models to advance preclinical research and guide personalised medicine approaches. Recent technological developments have permitted the maintenance, expansion and cryopreservation of GBM explant organoid (GBO) tissue. GBOs represent a translational leap forward and are currently the state-of-the-art in 3D in vitro culture system, retaining brain cancer heterogeneity, and transiently maintaining the immune infiltrate and tumour microenvironment (TME). Here, we provide a review of existing brain cancer organoid technologies, in vivo xenograft approaches, evaluate in-detail the key advantages and limitations of this rapidly emerging technology, and consider solutions to overcome these difficulties. GBOs currently hold significant promise, with the potential to emerge as the key translational tool to synergise and enhance next-generation omics efforts and guide personalised medicine approaches for brain cancer patients into the future.
Forecasting geothermal temperature in western Yemen with Bayesian-optimized machine learning regression models
Authors: Al-Fakih Abdulrahman , Al-khudafi Abbas , Koeshidayatullah Ardiansyah , Kaka SanLinn , Al-Gathe Abdelrigeeb 
Published: January 2025

Abstract
Geothermal energy is a sustainable resource for power generation, particularly in Yemen. Efficient utilization necessitates accurate forecasting of subsurface temperatures, which is challenging with conventional methods. This research leverages machine learning (ML) to optimize geothermal temperature forecasting in Yemen’s western region. The data set, collected from 108 geothermal wells, was divided into two sets: set 1 with 1402 data points and set 2 with 995 data points. Feature engineering prepared the data for model training. We evaluated a suite of machine learning regression models, from simple linear regression (SLR) to multi-layer perceptron (MLP). Hyperparameter tuning using Bayesian optimization (BO) was selected as the optimization process to boost model accuracy and performance. The MLP model outperformed others, achieving high

$$\text {R}^{2}$$

R
2

values and low error values across all metrics after BO. Specifically, MLP achieved

$$\text {R}^{2}$$

R
2

of 0.999, with MAE of 0.218, RMSE of 0.285, RAE of 4.071%, and RRSE of 4.011%. BO significantly upgraded the Gaussian process model, achieving an

$$\text {R}^{2}$$

R
2

of 0.996, a minimum MAE of 0.283, RMSE of 0.575, RAE of 5.453%, and RRSE of 8.717%. The models demonstrated robust generalization capabilities with high

$$\text {R}^{2}$$

R
2

values and low error metrics (MAE and RMSE) across all sets. This study highlights the potential of enhanced ML techniques and the novel BO in optimizing geothermal energy resource exploitation, contributing significantly to renewable energy research and development.
An investigation into the impact of diapir structures on formation pressure systems: a case study of the Yinggehai Basin, China
Authors: Jintao An , Jun Li , Huang Honglin , Zhang Hui , Yang Hongwei , Zhang Geng , Chen Sainan 
Published: January 2025

AbstractUnder the influence of diapir structure, the formation pressure system is complicated. The characteristics of high temperature and high pressure are obvious, the prediction is difficult, and complex accidents such as well kick and leakage are frequent, which seriously restrict the efficient development of oil and gas resources. Therefore, taking Yinggehai Basin in China as an example, combined with the evolution characteristics of diapir structure, the influence of diapir structure on abnormal high-pressure, wellhole collapse and fracture is analyzed. Three pressure calculation methods are selected, and the distribution rules of pressures and safety density window are analyzed, too. The results show that the diapir structure and its associated fault not only constitute the fluid transport system, but also make the deep overpressure transfer upward and accumulate into high pressure in the shallow formation, and the development of the associated fault destroy the integrity of the formation rock and reduce the strength of the rock. The upwelling of hot fluid changes the local geothermal conditions, reduces the hydrocarbon generation threshold of shallow source rocks, promotes the evolution of clay minerals, causes hydrothermal expansion, and enhances the shallow high pressure. In high-temperature environment, the cooling effect of drilling fluid will produce heating stress, change the stress distribution around the wellhole, and increase the risk of wellbore instability. Additionally, under the influence of diapir structures, the pore pressure in deep formations increases, while the fracture pressure decreases, resulting in a significantly narrowed safe density window. The safety density window width generally presents a half-spindle shape, and with the increase of depth, the window width increases first and then decreases.
A hybrid framework for assessing Pakistani commercial bank performance using multi-criteria decision-making
Authors: Işık Özcan , Shabir Mohsin , Demir Gülay , Puska Adis , Pamucar Dragan 
Published: January 2025

Abstract
Overall bank performance in a particular year or period is important to all banking industry stakeholders, as it indicates their success or failure relative to predetermined targets. Due to conflicting criteria and uncertainties, assessing bank performance is a complicated decision-making problem. The current paper proposes the Fuzzy Level Based Weight Assessment (F-LBWA), the Fuzzy Logarithm Methodology of Additive Weights (F-LMAW), and the Measurement Alternatives and Ranking according to the Compromise Solution (MARCOS) combination as a practical and robust decision-making tool to cope with many complex ambiguities. In the first phase, the suggested hybrid Multi-Criteria Decision-Making (MCDM) approach estimates the weight coefficients of the performance criteria with the aid of a combined version of the F-LBWA and F-LMAW methods. In the second phase, the MARCOS method determines the ranking performance of the decision alternatives. The introduced model is tested and validated on a case study assessing publicly traded bank performance in Pakistan. The findings obtained from the sensitivity analysis revealed that the presented F-LBWA-F-LMAW-MARCOS approach produces consistent solutions and is a reliable and effective procedure in rational decision-making.
Process-induced toxicants in food: an overview on structures, formation pathways, sensory properties, safety and health implications
Authors: Mirza Alizadeh Adel , Mohammadi Mansoureh , Hashempour-baltork Fataneh , Hosseini Hedayat , Shahidi Fereidoon 
Published: January 2025

Abstract
With the rapid advances in ready-to-eat food products and the progress of food processing industries, concerns about food security and investigating food safety as well as sensory quality have intensified. Many food safety concerns are attributed to the toxic components, which can be produced during food processing as process-induced toxicants (PITs). The thermal processing of food (e.g., baking, cooking, grilling, roasting, and toasting) may lead to the formation of some highly hazardous PITs for humans and animals. These include acrolein, acrylamide, benzene, ethyl carbamate, chlorinated compounds, heterocyclic organic compounds (HOCs), polycyclic aromatic hydrocarbons (PAHs), heterocyclic aromatic amines (HAAs), biogenic amines (BAs), N-nitrosamines, Maillard reaction products (MRPs), and several newly identified toxicants such as 3-monochloropropane-1,2-diol. The occurrence of these contaminants is often accompanied by distinguishing odor, taste, and color. The severity of the sensory attributes can vary depending on the compound concentration. Knowledge about the biochemical and chemical mechanisms of PITs generation is necessary for expanding feasible approaches to limit and control their amounts in food products. This contribution introduces the most significant PITs, highlighting their formation mechanisms, impact on sensory characteristics of foods, analytical methods to detection, risk assessments, and food safety/adverse health effects of ultra-processed foods.

Graphical Abstract
Is routine preoperative head ultrasound screening before congenital cardiac surgery mandatory?
Authors: Farooq Shawana , Hassan Hanan Rashid Abu , AlSassi Omai Mohammed , Alfawzan Tarek , Eltayeb Abdullah , Mohamed Seifeldin , Rafique Suffura , Ali Ghaida Mohammed , Alanezi Tarek Jamal , Alharbi Ali Hussain , Tabarki Brahim , Al Wadai Abdullah 
Published: January 2025

Abstract
Background
The practice of routine preoperative head ultrasound (HUS) screening for infants and neonates undergoing surgery for congenital heart disease has been widely adopted; however, its usefulness is still unclear. Therefore, this study aimed to determine the prevalence of preoperative HUS abnormalities in neonates and infants with congenital heart disease, its association with postoperative neurological outcomes, and its sensitivity and specificity in detecting preoperative abnormalities. This retrospective cohort study was conducted between 2015 and 2022 at a tertiary referral center. The study included 596 children who were scheduled for cardiac surgery for congenital heart disease and who had preoperative HUS.

Results
The prevalence of preoperative HUS abnormalities was 23% (n = 137). There were no differences in the baseline characteristics between patients with normal and abnormal HUS. The most common abnormality reported by HUS was intraventricular hemorrhage (IVH) (n = 65, 47.45%). Surgery was done in 417 (78.53%) with no IVH vs. 50 (76.92%) with IVH (P = 0.766). Mortality was statistically not significantly higher in patients with abnormal HUS (14% vs. 8%; P = 0.092). Twenty-seven patients developed new postoperative neurological complications (5.78%), with no difference between the groups (5.7% vs. 6.1%, P = 0.893). Preoperative neurological abnormalities (OR: 1.24 (95% CI: 1.08–1.41); P = 0.002) and intrauterine growth retardation (OR: 5.37 (95% CI: 1.61–17.88), P = 0.006) were significantly associated with new postoperative neurological events. The sensitivity of HUS compared with that of MRI was 51%, and the specificity was 83%.

Conclusions
The HUS showed a high percentage of abnormal findings in children with congenital heart disease; however, these findings were not necessarily correlated with the outcome. The study findings do not support the routine use of HUS for neonates and infants undergoing surgery for congenital heart disease. Abnormal HUS findings did not significantly impact surgical rates or postoperative outcomes.
An Interesting Case of Vitamin D-Mediated Severe Hypercalcemia in a Patient With Renal Mass
Authors: L Aravind , Viswanath S Arun , G Ninoo George , Jeyasekharan Ranjit , David Deepak , Ovett Jerin J 
Published: January 2025

Abstract
Hypercalcemia of malignancy (HCM) is the most common cause of hypercalcemia in hospitalized patients. The pathogenesis of HCM is often multifactorial. One of the rare causes of HCM is extra-renal production of 1,25-dihydroxyvitamin D (or calcitriol), which is often seen in patients with lymphoproliferative malignancies. Here we report an interesting case of a 77-year-old female with severe hypercalcemia and renal mass. Initially, she was presumed to have humoral hypercalcemia of malignancy. However, her renal mass turned out to be diffuse large B cell lymphoma upon removal. Her severe hypercalcemia was attributed to a combination of ectopic calcitriol production from the tumor and probable iatrogenic vitamin D intoxication. This case highlights the need to consider multiple concurrent etiologies in patients with severe hypercalcemia.
Discrepancies Between Sex Prediction and Fetal Sex After Prenatal Noninvasive Cell-Free DNA Screening
Authors: Witchel Selma F , Rajkovic Aleksandar , Yatsenko Svetlana A 
Published: January 2025

Abstract
In the last 10 years the field of prenatal diagnosis has been significantly reshaped followed by the implementation of noninvasive prenatal cell-free DNA (cfDNA) testing methodologies in clinical practice. Based on a superior performance and higher sensitivity and specificity than the former practice of biochemical markers screening, the American College of Obstetricians and Gynecologists and American College of Medical Genetics and Genomics recommend noninvasive prenatal cfDNA screening for trisomy 21, 18, 13, and sex chromosome aneuploidy to all pregnant people. While cfDNA screening is helpful in risk assessment for the most common autosomal trisomies, cfDNA also provides information about fetal sex chromosomes. Prediction of fetal sex is highly desired by the parents and also useful to healthcare providers for management of pregnancies that are at-risk for X-linked conditions. In fact, utilization of cfDNA screening has resulted in a significant number of referrals to evaluate discordant results for cfDNA sex prediction and appearance of fetal genitalia by prenatal ultrasound scan or at birth raising concerns about the fetus/infant atypical sex development known as a difference in sex development (DSD). In this mini-review, we outline principles and limitations of cfDNA technology, summarize recent findings related to cfDNA test performance in prediction of sex chromosome abnormalities and DSD conditions, define the technical and biological causes of discrepant results, provide recommendations to consolidate efforts by prenatal and clinical management teams in challenging situations, and discuss ethical considerations associated with fetal sex prediction and prenatal DSD diagnosis.
An Overview of Complications and Treatment Strategies in Periocular Dermal Fillers: A Literature Review
Authors: Ciesielska Aleksandra , Sieradzka Aleksandra , Szerej Krzysztof , Kot Alicja , Wojtczak Marta , Myśliwiec Natalia , Różycki Adrian , Pniak Michał , Miklis Paweł , Mawlichanów Maciej 
Published: January 2025

Introduction: The dermal filler market is a continuously expanding billion-dollar industry with the number of performed injections growing concurrently with the amount of post-injection complications. Most adverse events are mild and resolve spontaneously. Ischemic complications due to accidental intra-arterial filler injection may lead to skin necrosis and even irreversible vision loss.
Aim of the study: This review aims to critically evaluate the use of dermal fillers in the periocular area, possible post-injection complications and treatment options for adverse events, providing further guidance for aesthetic medicine doctors.
Methods: Databases such as PubMed, Medline and Research Gate were searched for articles published over the last 20 years.
Results: Dermal fillers in the periocular area are often chosen over surgical procedures due to their efficacy and outstanding safety profiles. The reversing agent hyaluronidase causes hyaluronic acid fillers to be the primary choice for periocular filler injections. Post-injection complications after permanent fillers may require surgical excision.
Conclusions: The periocular region is exceptionally demanding, requiring excellent anatomical awareness and proper administration techniques for uneventful procedures. Individually adjusted treatment plans and proper product selection is crucial. Doctors must follow preventative guidelines to minimize the complication risk, including aspirating before injecting the product, performing injections in the mid or deep dermal plane and administering small volumes with slow injections. Imaging techniques are significantly beneficial for minimizing the risk of the most severe ischemic complications.
Epstein-Barr virus (EBV) and systemic lupus erythematosus (SLE) association in serological studies
Authors: Czyż Witold , Chuncia-Ileczko Marta , Wójcikiewicz Michalina , Arczewski Filip , Dziedzic Karol , Kulbacka Julia , Wojszczyk Maciej , Zys Damian , Pasek Piotr , Ryniecka Julia 
Published: January 2025

Over the past 50 years, a substantial body of research revealed an association between Epstein-Barr virus (EBV), and various aspects of EBV infection, with multiple autoimmune diseases. Growing evidence points to EBV as a potential co-factor in systemic lupus erythematosus (SLE) and several mechanisms have been proposed to explain this relationship, however there is as yet no conclusive proof of causality. This literature review constitutes an introduction into the subject and attempts to outline the findings on the EBV-SLE connection, focusing mostly on the evidence provided by serological studies.
Patients with hard-to-heal wounds: a review and synthesis of their experiences and perceptions of maggot debridement
Authors: Eng Yu An , Thian Jie Yun , Ignacio Jeanette 
Published: January 2025

Objective: There is little use of maggot debridement therapy (MDT) worldwide, albeit there is much literature supporting its benefits and effectiveness for hard-to-heal (chronic) wounds. Hard-to-heal wounds are becoming ever more prevalent and MDT can play a pivotal role in wound care management. This underuse can be associated with patients' perceptions and experiences of MDT. The aim of this study was to synthesise available evidence exploring the perceptions and experiences of patients with hard-to-heal wounds regarding MDT. Method: This was a systematic review of qualitative evidence using thematic synthesis. Published papers and grey literature from inception until December 2021 were identified from PubMed, Embase, Cochrane, CINAHL, PsycINFO, ProQuest Social Science Premium Collection, Academic Search Complete, Web of Science, WorldWideScience.org , MedNar and Scopus. The screening process, assessment of methodological quality, and data extraction were conducted by two independent reviewers. Papers included had qualitative designs, such as phenomenology and descriptive–exploratory. Mixed methods papers and case reports were included for their qualitative components. Eligible papers were appraised using checklists from the Joanna Briggs Institute for qualitative research and case reports. Data were extracted using a standardised form. Findings were synthesised using Thomas and Harden's thematic synthesis approach. Results: A total of six papers exploring patients' (n=67) perceptions and experiences regarding MDT were included. Some 52 findings were grouped into 11 categories, generating three synthesised findings: the complexity of living with a hard-to-heal wound and seeking help; the effects of interpersonal relationships; and the relationship between the individual and the larvae. Conclusion: Findings of the review showed that health professionals are key drivers in encouraging patients' acceptance of MDT and enhancing their treatment experiences. Together with a patient-centric approach, patients' concerns can be effectively addressed. Public and patient education can be beneficial to address misconceptions regarding the therapy.