bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Aquatic Exercise Therapy dan Lari Terhadap Cardiorespiratory Fitness Pada Remaja
Authors: Windiastoni Yoga Handita , Haritsah Nurul Fithriati 
Published: February 2023

Presentase penduduk Indonesia yang dikategorikan beraktivitas fisik rendah sebanyak 29,9% dari total seluruh penduduk pada tahun 2010, 31,9% laki-laki dan 27,9% perempuan. Dampak yang terjadi akibat penurunan aktivitas fisik seseorang yaitu meningkatnya resiko penyakit kardiovaskuler. Oleh karena itu, dibutuhkan cardiorespiratory fitness yang adekuat untuk mengurangi resiko penyakit kardiovaskuler. Cardiorespiratory fitness adalah kemampuan tubuh mengantarkan oksigen ke otot selama latihan .Salah satu cara meningkatkan cardiorespiratory fitness adalah dengan menggunakan Aquatic Exercise Therapy dan Lari. Metode penelitian yang digunakan yaitu penelitian kuantitatif dengan desain eksperimental pre-test and post-test two group design. Penelitian ini dilaksanakan pada bulan Oktober 2020. Pada Kelompok I didapatkan hasil p = 0,000 ( p < 0,05), disimpulkan ada pengaruh latihan aquatic exercise therapy. Pada Kelompok II didapatkan hasil p = 0,000 ( p < 0,000), disimpulkan ada pengaruh latihan lari, kelompok yang mempunyai different mean lebih tinggi yaitu kelompok aquatic exercise therapy dengan hasil 7,225. Ada pengaruh latihan aquatic exercise therapy terhadap cardiorespiratory fitness nilai p= 0,000 (p<0,005), (2) Ada pengaruh lari terhadap cardiorespiratory fitness nilai p=0,000 (p<0,005), (3) Aquatic exercise therapy lebih berpengaruh dibandingkan dengan lari dengan selisih mean kelompok I 7,22 dan kelompok II 2,94.
RELATIONSHIP OF DEPRESSION LEVEL ON QUALITY OF LIFE OF ELDERLY HYPERTENSION PATIENTS IN RW 03 DESA LIMBANGAN KEC. LIBANGAN KAB. KENDAL
Authors: Prianahatin Ari Loga , Retnaningsih Dwi 
Published: February 2023

ABSTRACT
Background: Hypertension is still a health problem faced by the elderly which is basically quite complex. Health problems that usually arise, for example, are related to changes in the cardiovascular system, which if left unchecked will interfere with the function of other organs. So the issue arises when feelings of anxiety and depression are experienced by the elderly. This study aims to determine the level of depression on the quality of life of elderly people with hypertension.
Research Methods: The type of research used is the quantitative method, with a cross-sectional design where data collection for independent and dependent variables is carried out at the same time. The research instrument used was a questionnaire in which the questionnaire was not tested for validity because it had been tested for validity in the research of Roudhotul Auliyak and Chasanah. The research respondents consisted of 40 elderly people with hypertension who were taken using a total sampling technique. This research was conducted on 8-10 June 2021 in RW 03 Limbangan Village, Limbangan District, Kendal Regency. The test analysis method used is Rank Spearman.
Result: There is a relationship between the level of anxiety and depression and the quality of life of the elderly with hypertension in RW 03, Limbangan Village, Limbangan District, Kendal Regency. The results of the analysis using the Spearman rank correlation test regarding depression on the quality of life of elderly people with hypertension, p value = 0.001 means p value
EFFECTS OF EXERCISE THERAPY WITH THE BOBATH METHOD ON BALANCE IN A CHILD WITH SPASTIC DIPLEGIC CEREBRAL PALSY: A CASE REPORT
Authors: Salsabilla Alifia Husnun , Rahman Farid 
Published: February 2023

ABSTRACT
The overall birth prevalence of cerebral palsy is about 2 per 1000 live births. Weakness in balance control is one of the most common problems encountered in children with CP. One of the most widely used physiotherapy approaches for children with CP is Bobath therapy. Exercise with the Bobath method can improve postural control and balance in children with CP. This study aims is to determine the effect of exercise therapy with the Bobath method for balance in a child with spastic diplegic cerebral palsy. This study using a single-subject research conducted on a child with a diagnosis of spastic diplegic cerebral palsy who was given exercise therapy using the Bobath method 4 times a week for 4 weeks. Measurement of balance using the Pediatric Balance Scale (PBS) which was carried out before exercise therapy was given (A1), follow-up (A2), and evaluation of the final outcome (A3). The results showed that the patient had an increase in the PBS score, which means that there was an increase in functional balance. The conclusion of this study is that exercise therapy with the Bobath method which has been carried out 4 times a week for 4 weeks improves functional balance in a child with a diagnosis of spastic diplegic cerebral palsy.

Keywords: Cerebral Palsy, Balance, Bobath Method
KANDUNGAN NITRAT DAN FOSFAT SEDIMEN PADA KAWASAN PADANG LAMUN DI PERAIRAN KOLESE KOTA BAUBAU
Authors: Indriyani Rinda , Nurgayah Wa , Ira Ira 
Published: February 2023

Nutrien seperti nitrat dan fosfat penting dalam proses pertumbuhan dan perkembangan sumber daya hayati laut. Pengambilan data dilaksanakan pada bulan Oktober-November 2021 di Perairan Kelurahan Kolese, Kota Baubau. Tujuan penelitian ini untuk mengetahui persentase tutupan lamun, kandungan nitrat dan fosfat dalam sedimem, serta hubungan kandungan nitrat dan fosfat dalam sedimen terhadap tutupan lamun. Tutupan lamun pada tiga stasiun pengamatan diambil menggunakan transek kuadrat. Pengambilan data lamun sebanyak 3 kali ulangan pada setiap stasiun pengamatan. Sampel sedimen untuk mengukur nitrat dan fosfat sedimen diambil disemua stasiun pengamatan. Hubungan kandungan nitrat dan fosfat pada sedimen terhadap persentase tutupan lamun diuji menggunakan analisis regresi berganda. Hasil analisis menunjukkan kandungan nitrat dalam sedimen pada stasiun pengamatan berkisar 1,22-1,41 mg/L, sedangkan kandungan fosfat disedimen berkisar 0,052-0,067 mg/L. Tutupan lamun tertinggi ditemukan pada Stasiun I yaitu 64,1%, sedangkan tutupan lamun terendah pada stasiun II yaitu 22,8%. Terdapat hubungan yang kuat antara kandungan nitrat dan fosfat terhadap persentase tutupan lamun, dengan nilai korelasi 0,800. Nilai determinasi regresi (R) sebesar 0,639 menunjukkan kandungan nitrat dan fosfat memberikan pengaruh sebesar 63,9% terhadap persentase tutupan lamun dan sisanya dipengaruhi oleh faktor lingkungan perairan lainnya.Kata kunci: Padang lamun,Fosfat, Nitrat, Sedimen, Kelurahan Kolese.
Transient dystonia correlates with parkinsonism after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine in non- human primates
Authors: Norris S. A. , Tian L. , Williams E. L. , Perlmutter J. S. 
Published: February 2023

Unilateral internal carotid artery 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion in non-human primates produces transient contralateral hemi-dystonia followed by stable contralateral hemi-parkinsonism; the relationship between dystonia and parkinsonism remains unclear. We hypothesized that transient dystonia severity following MPTP correlates with parkinsonism severity. In male Macaca nemestrina (n = 3) and M. fascicularis (n = 17) we administered unilateral intra-carotid MPTP, then correlated validated blinded ratings of transient peak dystonia and delayed parkinsonism. We also correlated dystonia severity with post-mortem measures of residual striatal dopamine and nigral neuron counts obtained a mean 53 ± 15 days following MPTP, after resolution of dystonia but during stable parkinsonism. Median latency to dystonia onset was 1 day, and peak severity 2.5 days after MPTP; total dystonia duration was 13.5 days. Parkinsonism peaked a median of 19.5 days after MPTP, remaining nearly constant thereafter. Peak dystonia severity highly correlated with parkinsonism severity (r[18] = 0.82, p &lt; 0.001). Residual cell counts in lesioned nigra correlated linearly with peak dystonia scores (r[18] = −0.68, p=&lt;0.001). Dystonia was not observed in monkeys without striatal dopamine depletion (n = 2); dystonia severity correlated with striatal dopamine depletion when residual nigral cell loss was less than 50% ([11]r = −0.83, p &lt; 0.001) but spanned a broad range with near complete striatal dopamine depletion, when nigral cell loss was greater than 50%. Our data indicate that residual striatal dopamine may not reflect dystonia severity. We speculate on mechanisms of transient dystonia followed by parkinsonism that may be studied using this particular NHP MPTP model to better understand relationships of transient dystonia to nigrostriatal injury and parkinsonism.
High fibrinogen and mixed proximal and distal thrombosis are associated with the risk of residual venous thrombosis in patients with posttraumatic deep vein thrombosis
Authors: Liu Yating , Deng Xiaozhi , Zhu Fang , Zhu Wenhui , Wang Zheng 
Published: February 2023

BackgroundThe risk factors for residual venous thrombosis (RVT) in patients with post-trauma deep vein thrombosis (DVT) are unknown.MethodsWe evaluated 127 patients with DVT after trauma, all of whom were treated with conventional anticoagulation and assessed for the presence of RVT with venous compression ultrasound (CUS), using an internal diameter of the venous lumen ≥ 4 mm after compression as the criterion.ResultsRVT was present in 59 (46%) patients, and complete thrombus dissolution was present in 68 (54%) patients. Among them, mixed proximal and distal thrombosis (OR, 4.292; 95% CI, 1.253–14.707), diabetes (OR, 6.345; 95% CI, 1.125–35.786), fibrinogen &gt; 4.145 g/L (OR, 2.858; 95% CI, 1.034–7.897), the time between detection of thrombus and initiation of antithrombotic therapy &gt; 2.5 days (OR, 3.470; 95% CI, 1.085–11.094) was an independent risk factor for RVT in patients with posttraumatic DVT.ConclusionA mixed proximal and distal thrombosis, diabetes mellitus, late initiation of antithrombotic therapy, and high fibrinogen levels increase the risk of RVT in patients with posttraumatic DVT. Therefore, treatment regimens for patients with posttraumatic DVT can be adjusted according to the site of thrombosis, the presence of diabetes mellitus, and the level of fibrinogen, and antithrombotic therapy can be started as early as possible after the detection of thrombosis to prevent the development of RVT and its serious complications.
Host-pathogen interaction in arthropod vectors: Lessons from viral infections
Authors: Perveen Nighat , Muhammad Khalid , Muzaffar Sabir Bin , Zaheer Tean , Munawar Nayla , Gajic Bojan , Sparagano Olivier Andre , Kishore Uday , Willingham Arve Lee 
Published: February 2023

Haematophagous arthropods can harbor various pathogens including viruses, bacteria, protozoa, and nematodes. Insects possess an innate immune system comprising of both cellular and humoral components to fight against various infections. Haemocytes, the cellular components of haemolymph, are central to the insect immune system as their primary functions include phagocytosis, encapsulation, coagulation, detoxification, and storage and distribution of nutritive materials. Plasmatocytes and granulocytes are also involved in cellular defense responses. Blood-feeding arthropods, such as mosquitoes and ticks, can harbour a variety of viral pathogens that can cause infectious diseases in both human and animal hosts. Therefore, it is imperative to study the virus-vector-host relationships since arthropod vectors are important constituents of the ecosystem. Regardless of the complex immune response of these arthropod vectors, the viruses usually manage to survive and are transmitted to the eventual host. A multidisciplinary approach utilizing novel and strategic interventions is required to control ectoparasite infestations and block vector-borne transmission of viral pathogens to humans and animals. In this review, we discuss the arthropod immune response to viral infections with a primary focus on the innate immune responses of ticks and mosquitoes. We aim to summarize critically the vector immune system and their infection transmission strategies to mammalian hosts to foster debate that could help in developing new therapeutic strategies to protect human and animal hosts against arthropod-borne viral infections.
CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation
Authors: Barden Markus , Holzinger Astrid , Velas Lukas , Mezősi-Csaplár Marianna , Szöőr Árpád , Vereb György , Schütz Gerhard J. , Hombach Andreas A. , Abken Hinrich 
Published: February 2023

In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell activation. It is unresolved whether CAR-mediated T cell activation depends on the presence of the TCR and whether CAR and TCR mutually cross-activate upon engaging their respective antigen. Here we demonstrate that the CD3ζ CAR level was independent of the TCR associated CD3ζ and could not replace CD3ζ to rescue the TCR complex in CD3ζ KO T cells. Upon activation, the CAR did not induce phosphorylation of TCR associated CD3ζ and, vice versa, TCR activation did not induce CAR CD3ζ phosphorylation. Consequently, CAR and TCR did not cross-signal to trigger T cell effector functions. On the membrane level, TCR and CAR formed separate synapses upon antigen engagement as revealed by total internal reflection fluorescence (TIRF) and fast AiryScan microscopy. Upon engaging their respective antigen, however, CAR and TCR could co-operate in triggering effector functions through combinatorial signaling allowing logic “AND” gating in target recognition. Data also imply that tonic TCR signaling can support CAR-mediated T cell activation emphasizing the potential relevance of the endogenous TCR for maintaining T cell capacities in the long-term.
Influence of active cooling on microstructure and mechanical properties of wire arc additively manufactured mild steel
Authors: Dash Aruntapan , Squires Lile , Avila Jose D. , Bose Susmita , Bandyopadhyay Amit 
Published: February 2023

Additive manufacturing (AM) of metals attracts attention because it can produce complex structures in a single step without part-specific tooling. Wire arc additive manufacturing (WAAM), a welding-based method that deposits metal layer by layer, is gaining popularity due to its low cost of operation, feasibility for large-scale part fabrication, and ease of operation. This article presents the fabrication of cylindricalshaped mild steel (ER70S-6) samples with a gas metal arc (MIG)—based hybrid WAAM system. A mechanism for actively cooling the substrate is implemented. Deposition parameters are held constant to evaluate the impact of active cooling on deposition quality, inter-pass cooling time, and internal defects. Surface and volume defects can be seen on the cylindrical sample fabricated without an active cooling setup. Defect quantification and phase analysis are performed. The primary phase formed was α-iron in all samples. Actively cooled deposition cross section showed a 99% decrease of incomplete fusion or porosity, with temperature measured 60 s after deposition averaging 235°C less than non-cooled. Microstructural analysis revealed uniformity along the build direction for actively cooled deposition but non-uniform microstructures without cooling. Hardness decreased by approximately 22HV from the first layer to the final layer in all cases. Property variation can be attributed to the respective processing strategies. The current study has demonstrated that active cooling can reduce production time and porosity while maintaining uniform microstructure along the build direction. Such an approach is expected to enhance the reliability of WAAM-processed parts in the coming days.
Clinical risk score for early prediction of recurring SARS-CoV-2 positivity in non-critical patients
Authors: Li Anni , Wang Chao , Cui An , Zhou Lingyu , Hu Wei , Ma Senlin , Zhang Dian , Huang Hong , Chen Mingquan 
Published: February 2023

IntroductionRecurrent positive results in quantitative reverse transcriptase-PCR (qRT-PCR) tests have been commonly observed in COVID-19 patients. We aimed to construct and validate a reliable risk stratification tool for early predictions of non-critical COVID-19 survivors’ risk of getting tested re-positive within 30 days.MethodsWe enrolled and retrospectively analyzed the demographic data and clinical characters of 23,145 laboratory-confirmed cases with non-critical COVID-19. Participants were followed for 30 days and randomly allocated to either a training (60%) or a validation (40%) cohort. Multivariate logistic regression models were employed to identify possible risk factors with the SARS-CoV-2 recurrent positivity and then incorporated into the nomogram.ResultsThe study showed that the overall proportion of re-positive cases within 30 days of the last negative test was 24.1%. In the training cohort, significantly contributing variables associated with the 30-day re-positivity were clinical type, COVID-19 vaccination status, myalgia, headache, admission time, and first negative conversion, which were integrated to build a nomogram and subsequently translate these scores into an online publicly available risk calculator (https://anananan1.shinyapps.io/DynNomapp2/). The AUC in the training cohort was 0.719 [95% confidence interval (CI), 0.712–0.727] with a sensitivity of 66.52% (95% CI, 65.73–67.30) and a specificity of 67.74% (95% CI, 66.97–68.52). A significant AUC of 0.716 (95% CI, 0.706–0.725) was obtained for the validation cohort with a sensitivity of 62.29% (95% CI, 61.30–63.28) and a specificity of 71.26% (95% CI, 70.34–72.18). The calibration curve exhibited a good coherence between the actual observation and predicted outcomes.ConclusionThe risk model can help identify and take proper management in high-risk individuals toward the containment of the pandemic in the community.
Frailty modifies the effect of polypharmacy and multimorbidity on the risk of death among nursing home residents: Results from the SHELTER study
Authors: Zazzara Maria Beatrice , Villani Emanuele Rocco , Palmer Katie , Fialova Daniela , Corsonello Andrea , Soraci Luca , Fusco Domenico , Cipriani Maria Camilla , Denkinger Michael , Onder Graziano , Liperoti Rosa 
Published: February 2023

BackgroundFrailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them in terms of outcomes such as mortality. Aims of the study were to (i) assess whether nursing home residents with polypharmacy (5–9 medications) or hyperpolypharmacy (≥10 drugs), have an increased risk of death and (ii) whether any association is modified by the co-presence of frailty or disability.MethodsCohort study with longitudinal mortality data including 4,023 residents from 50 European and 7 Israeli NH facilities (mean age = 83.6 years, 73.2% female) in The Services and Health for Elderly in Long Term care (SHELTER) cohort study. Participants were evaluated with the interRAI-LongTerm Care assessment tool. Frailty was evaluated with the FRAIL-NH scale. Hazard ratio (HR) of death over 12 months was assessed with stratified Cox proportional hazards models adjusted for demographics, facilities, and cognitive status.Results1,042 (25.9%) participants were not on polypharmacy, 49.8% (n = 2,002) were on polypharmacy, and 24.3% (n = 979) on hyperpolypharmacy. Frailty and disability mostly increased risk of death in the study population (frailty: HR = 1.85, 95%CI 1.49–2.28; disability: HR = 2.10, 95%CI 1.86–2.47). Among non-frail participants, multimorbidity (HR = 1.34, 95%CI = 1.01–1.82) and hyperpolypharmacy (HR = 1.61, 95%CI = 1.09–2.40) were associated with higher risk of death. Among frail participants, no other factors were associated with mortality. Polypharmacy and multimorbidity were not associated with mortality after stratification for disability.ConclusionsFrailty and disability are the strongest predictors of death in NH residents. Multimorbidity and hyperpolypharmacy increase mortality only in people without frailty. These findings may be relevant to identify patients who could benefit from tailored deprescription.
NAMPT and NAPRT serum levels predict response to anti-TNF therapy in inflammatory bowel disease
Authors: Colombo Giorgia , Caviglia Gian Paolo , Ravera Alberto , Tribocco Elisa , Frara Simone , Rosso Chiara , Travelli Cristina , Genazzani Armando A. , Ribaldone Davide Giuseppe 
Published: February 2023

BackgroundNicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyl transferase (NAPRT) are key intracellular enzymes that participate in the biosynthesis on NAD but have also been shown to be released as proinflammatory cytokines. A number of reports have shown that circulating NAMPT is increased in serum of patients with inflammatory disorders, including inflammatory bowel diseases (IBD), while nothing is known regarding circulating NAPRT and the presence of both cytokines in IBD patient stools. In the present study, we evaluated eNAMPT and eNAPRT levels in a large cohort of IBD patients not on biological therapy and in a subset that then was prescribed biologics.MethodsWe conducted a retro-perspective study on 180 patients, of which 111 underwent subsequent biological treatment (adalimumab, vedolizumab, and ustekinumab). We analyzed eNAMPT and eNAPRT concentrations in serum and faces of IBD patients, correlating them with response to biologics.ResultsWe now report that eNAMPT and eNAPRT are significantly increased in both serum and stools of IBD patients. NAMPT and NAPRT levels correlate with disease severity, with C reactive protein and with serum IL-6 levels. Importantly, levels of NAMPT in patients starting treatment with adalimumab correlate with response failure at three months: patients with levels above 4 ng/ml were significantly less likely to obtain benefit. Serum NAMPT as a biomarker of response yields a sensitivity of 91% and a specificity of 100%.ConclusionThe present work strongly suggests that a prospective trial evaluating eNAMPT and eNAPRT levels in relation to response to biologicals in IBD should be initiated.