bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of ultrasound-assisted extraction of carotenoids and antioxidant activity from Citrus reticulata Blanco peels (Wilking mandarin)
Authors: Kadi A. , Boudries H. , Bachir-bey M. , Teffane M. , Taibi A. , Arroul Y. , Boulekbache-Makhlouf L. 
Published: July 2023

AbstractA large amount of waste, especially the outer part of citrus fruits (peel), is generated after consuming the pulp and it remains unused. The valorisation of this waste by recovering its bioactive compounds seems interesting. The aim of this study was to find the optimal conditions using ultrasound-assisted extraction (UAE) that yield the highest carotenoid content and better antioxidant activity from Citrus reticulata Blanco peels.Response surface methodology (RSM) through Box–Behnken experimental design was used to optimise the conditions for carotenoid extraction using UAE. Hexane concentration, temperature, and sonication time were selected as the main factors.The results revealed that all independent variables affected the responses. The optimal UAE conditions for hexane concentration, temperature, and sonication time were 60.76%, 36.45 °C, and 37.32 min, respectively. The values of total carotenoid content (TCC) and total antioxidant activity (TAA) obtained by UAE were higher than those obtained by the maceration extraction method.It can be concluded that the medium and extraction parameters, including hexane concentration, temperature, and sonication time, significantly influenced the recovery of carotenoids and antioxidant activity. The optimisation study allowed determining the appropriate conditions to maximise both responses. Compared to conventional maceration, the UAE method was superior and more efficient for extracting carotenoids from C. reticulata Blanco peels.
THE CORPORA-ORIENTED PROJECTS AND COURSES – INNOVATION OF THE UNIVERSITY LIFE
Authors: Tvaltvadze Darejan , Gvelesiani Irina 
Published: July 2023

The advancement of computer technologies opened up a bunch of opportunities in different spheres of life. Computer science has revolutionized the modes of studying and researching. The educators and policy makers started modernization of educational programs in accordance to the latest achievements in the field. The present paper deals with the presentation of the progressive university courses as well as the projects (winter schools, Akaki Shanidze’s Digital Library and Text Corpus, etc.) facilitating the integration of corpora in teaching and researching. The major accept is put on the successful modes of the enhancement of the learners’ digital skills (operation, application, problem solving, critical thinking, etc.), corpus-building abilities (annotation, orientation towards the scientific metalanguage, enrichment of metadata, etc.), corpora-based analysis (proper coinage, finding equivalency, plying with concepts and terms, etc.) as well as the corpus-oriented research. Determination of the major challenges and outcomes of the projects and courses, discussion of some gaps, introduction of the convenient opportunities of their “filling” – these are the major issues of the paper. The methodology of research includes observation, analysis and evaluation of the ongoing processes.
STUDENTS’ VIEWS ON HIGHER EDUCATION TRANSFORMATIONS CAUSED BY THE COVID-19 PANDEMIC: A COMPARATIVE STUDY FOR LATVIA AND UKRAINE
Authors: Usca Svetlana , Malykhin Oleksandr , Aristova Nataliia 
Published: July 2023

The study’s primary purpose was to compare Latvian and Ukrainian students’ views on transforming traditional learning process connected with implementing infection control measures aimed at preventing the spread of coronavirus and their consequences on higher education in both countries. In this study, the total number of respondents consisted of 207 undergraduate, graduate and postgraduate students from Latvia and Ukraine. Latvian research sample was presented by 109 students including 11 male students (10.09%) and 98 female students (89.91%). Ukrainian research sample consisted of 98 students including 16 male students (16.33%) and 82 female students (83.67%). A convenience sampling technique was used for selecting the research sample. The survey was conducted in October 2020 - March 2021. The current research is carried out within the project of National Academy of Educational Sciences of Ukraine “Organization of Educational Process in the Content of Unpredicted Changes (the Covid-19 Pandemic): Comparative Analysis (Ukraine – EU countries)”, No. 0121U108690.
ASSESSMENT OF TRANSPORT LOGISTICS' GRADUATES COMPETENCES FROM THE POINT OF VIEW OF EMPLOYERS
Authors: Ginavičienė Jurgita , Piščikienė Inga , Sprogytė-Bredelienė Indrė 
Published: July 2023

The modern logistics business world is changing and presents new challenges to companies, so it is currently necessary to pay attention to the competence of employees, but also to predict which of these competences will be necessary in the future. The aim of the this work was to research the competences of Vilnius College of Technologies and Design Transport Logistics graduates from the point of view of employers. Based on scientific literature and in dept interview of Lithuanian transport and logistics companies’ managers, the article reveals the significance of qualified transport logistics specialists. It presents the analysis of the competences of Vilnius College of Technology and Design Transport Logistics graduates. According to experts, 88.5 percent of Transport Logistics graduates of the Vilnius College of Technology and Design have very good knowledge and skills. They are zealous, possessing not only theoretical but also practical knowledge. They are able to analyse practical situations, not afraid of challenges.
PENGARUH PERUBAHAN VARIASI JUMLAH LUBANG INJEKTOR TERHADAP DAYA, TORSI, DAN KONSUMSI BAHAN BAKAR SEPEDA MOTOR VARIO 125CC
Authors: Mahendra Fahregi Alifian , Sumarli Sumarli , Harly Muhammad 
Published: July 2023

Teknologi sistem injeksi merupakan teknologi yang sedang berkembang dalam dunia otomotif. Teknologi tersebut mampu meningkatan performa mesin dan efisiensi bahan bakar. Sistem tersebut menggunakan beberapa sensor untuk menentukan volume dan waktu bahan yang disemprotkan berdasarkan nilai air fuel ratio yang sudah ditetapkan atau diprogram dalam sistem tersebut. Tujuan dari penelitian ini yaitu untuk mengetahui perbedaan torsi, daya, konsumsi bahan bakar pada sepeda motor Vario 125cc dengan variasi penggunaan injektor 4 lubang, 6 lubang dan 8 lubang. Rancangan penelitian dengan metode desain faktorial experimen. Hasil dari penelitian disimpulkan bahwa: 1). Tidak ada perbedaan yang signifikan pada penggunaan injektor 4 lubang, 6 lubang dan 8 lubang terhadap torsi sepeda motor Vario 125cc; 2). Tidak ada terdapat perbedaan yang signifikan pada penggunaan injektor 4 lubang, 6 lubang dan 8 lubang terhadap daya sepeda motor Vario 125cc; 3). Tidak terdapat perbedaan yang signifikan pada penggunaan injektor 4 lubang, 6 lubang dan 8 lubang terhadap konsumsi bahan bakar sepeda motor Vario 125cc.
A study on autologous non-cultured melanocyte transfer in patients of stable vitiligo at a tertiary care centre
Authors: Gupta Shaily , Agrawal Meetesh , Varma Krishnendra , Kumar Ujjwal , Bhargava Shashank 
Published: July 2023

Vitiligo is an acquired pigmentary disorder caused due to a loss of functional melanocytes. Autologous non-cultured melanocyte transfer (NCMT) is a recent surgical modality for the treatment of stable vitiligo.To evaluate the clinical outcome of NCMT in patients of stable vitiligo. Autologous melanocyte transfer was performed on 41 patients of stable vitiligo. They were evaluated at 1, 4, 12, 18 and 24 weeks post-surgery for extent for repigmentation and complications.In this study, the male- female ratio was nearly equal, with 51% males and 48% females the mean duration of stability of vitiligo lesion was 3.39 years. By 24 week of follow-up, 56.09% had excellent repigmentation (&#62;90%), while 31.70% patients had good pigmentation (75-90%). No significant complications in donor area or recipient site were noted.Autologous non-cultured melanocyte transfer is a quick, single day procedure, and can be performed on an out-patient basis. It requires lesser technicalities than other surgical procedures for treating vitiligo and can prove to be an effective treatment modality in achieving homogenous repigmentation with an excellent degree of patient satisfaction.
Hypofractionated Post-Prostatectomy Radiotherapy in 16 Fractions: A Single Institution Outcome
Authors: Dubinsky Pavol , Vojtek Vladimir , Belanova Katarina , Janickova Natalia , Balazova Noemi , Tomkova Zuzana 
Published: July 2023

Background: Optimal hypofractionated schedule of post-prostatectomy radiotherapy remains to be established. We evaluated treatment outcomes and toxicity of the moderately hypofractionated post-prostatectomy radiotherapy in 16 daily fractions delivered with IMRT/VMAT. The treatment schedule selection was motivated by limited technology resources. Methods: One hundred consecutive M0 patients with post-prostatectomy radiotherapy were evaluated. Radiotherapy indication was adjuvant (ART) in 19%, early salvage (eSRT) in 46% and salvage (SRT) in 35%. The dose prescription for prostate bed PTV was 52.8 Gy in 16 fractions of 3.3 Gy. The Common Terminology Criteria v.4 for Adverse Events scale was used for toxicity grading. Results: The median follow-up was 61 months. Five-year biochemical recurrence-free survival (bRFS) was 78.6%, distant metastases-free survival was 95.7% and overall survival was 98.8%. Treatment indication was the only significant factor for 5-year bRFS in multivariate analysis which was 84.6% vs. 67.6% for ART or eSRT vs. SRT respectively (HR 0.15, 95% CI 0.05–0.47, p=0.001). Acute GI toxicity grade 2 was recorded in 24%, grade 3 in 2% and acute GU toxicity grade 2 in 10% and no grade 3. Cumulative rate of late GI toxicity grade ≥2 was observed in 9% and late GU toxicity grade ≥2 in 16%. Conclusion: Observed results confirmed efficacy and acceptable toxicity of post-prostatectomy hypofractionated radiotherapy in 16 daily fractions.
QuickDASH and PRWE Are Not Optimal Patient-Reported Outcome Measures After Distal Radial Fracture Due to Ceiling Effect
Authors: Bell Katrina R. , Oliver William M. , White Timothy O. , Molyneux Samuel G. , Clement Nicholas D. , Duckworth Andrew D. 
Published: July 2023

Background:
The aim of this study was to determine the floor and ceiling effects for both the QuickDASH (shortened version of the Disabilities of the Arm, Shoulder and Hand [DASH] questionnaire) and the PRWE (Patient-Rated Wrist Evaluation) following a distal radial fracture (DRF). Secondary aims were to determine the degree to which patients with a floor or ceiling effect felt that their wrist was “normal” according to the Normal Wrist Score (NWS) and if there were patient factors associated with achieving a floor or ceiling effect.

Methods:
A retrospective cohort study of patients in whom a DRF was managed at the study center during a single year was undertaken. Outcome measures included the QuickDASH, PRWE, EuroQol-5 Dimensions-3 Levels (EQ-5D-3L), and NWS.

Results:
There were 526 patients with a mean age of 65 years (range, 20 to 95 years), and 421 (80%) were female. Most patients were managed nonsurgically (73%, n = 385). The mean follow-up was 4.8 years (range, 4.3 to 5.5 years). A ceiling effect was observed for both the QuickDASH (22.3% of patients with the best possible score) and the PRWE (28.5%). When defined as a score that differed from the best available score by less than the minimum clinically important difference (MCID) for the scoring system, the ceiling effect increased to 62.8% for the QuickDASH and 60% for the PRWE. Patients who had a ceiling score on the QuickDASH and the PWRE had a median NWS of 96 and 98, respectively, and those who had a score within 1 MCID of the ceiling score reported a median NWS of 91 and 92, respectively. On logistic regression analysis, a dominant-hand injury and better health-related quality of life were the factors associated with both QuickDASH and PRWE ceiling scores (all p < 0.05).

Conclusions:
The QuickDASH and PRWE demonstrate ceiling effects when used to assess the outcome of DRF management. Some patients achieving ceiling scores did not consider their wrist to be “normal.” Future research on patient-reported outcome assessment tools for DRFs should aim to limit the ceiling effect, especially for individuals or groups that are more likely to achieve a ceiling score.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Penegakan Disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar
Authors: Yalid  , Busrianto Busrianto 
Published: July 2023

Rumusan masalah dalam penelitian ini ada 3 (tiga). Pertama, bagaimana penegakan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar? Kedua, bagaimana kendala penegakan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar? Ketiga, agaimana upaya menegakkan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar? Sejalan dengan rumusan masalah tersebut maka tujuan penelitian ini pun ada 3 (tiga). Pertama, untuk menjelaskan penegakan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar. Kedua, untuk menjelaskan kendala penegakan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar. Ketiga, untuk menjelaskan upaya menegakkan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar. Jenis penelitian adalah penelitian hukum sosiologis, sesuai dengan jenisnya maka pendekatannya empiris. Hasil penelitian ini dapat dijelaskan bahwa wewenang Kepala Desa yang dapat memberhentikan Perangkat Sekretariat Desa sebagaimana berpedoman pada Daerah Kabupaten Kampar No. 12 Tahun 2017. Kendala penegakan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar disebabkan faktor jarak tempuh yang jauh, transportasi dan sarana komunikasi karena tidak semua desa di Kampar Kiri Hulu mempunyai jaringan telpon, sehingga untuk berkomunikasi dengan Perangkat Sekretariat Desa harus mencari dan berbicara secara langsung. Upaya menegakkan disiplin Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu Kabupaten Kampar diperlukan upaya berupa adanya standar disiplin sah menurut undang-undang yang berlaku. Terhadap hal ini pelayanan Perangkat Sekretariat Desa di Kecamatan Kampar Kiri Hulu sebagian saja yang sudah mempunyai standar dimaksud. Hal ini peroleh berdasarkan fakta hasil wawancara dengan responden terkait.
A monomeric StayGold fluorescent protein
Authors: Ivorra-Molla Esther , Akhuli Dipayan , McAndrew Martin , Scott William , Kumar Lokesh , Palani Saravanan , Mishima Masanori , Crow Allister , Balasubramanian Mohan 
Published: July 2023

Abstract
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favourable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we describe the 1.6 Å structure of StayGold and generate a new derivative (mStayGold) that retains the brightness and photostability of the original protein while being fully monomeric.
Influence of mining activities on hydrological processes in Pingshuo mining district, Loess Plateau: Insights from spatio-temporal variations of δD and δ18O
Authors: yang Nuan , Zhang Wenrui , Qu Shen , Yu Ruihong , Zhao Yuanzhen 
Published: July 2023

Abstract
Under the influence of mining activities, investigating hydrological processes is an important cornerstone of water resources and eco-environment protection. In this study, the stables isotopic compositions (δD and δ18O) of surface water and groundwater in five periods were analyzed to identify the formation and evolution of surface water and groundwater in mining district. The δD and δ18O indicate that the water bodies in the study area is mainly recharged by local precipitation and undergo evaporation. There is a close hydraulic connection between surface water, mine water and groundwater, the deep confined water is affected by the surface water and phreatic water due to the developing water-conducting fractures. The recharge of deep groundwater to the overlying aquifer may increase resulting in gradually obvious “oxygen drift” with the continuous development of fractures, which will decrease the degree of “oxygen drift” as the fractures reclogged. The δ18O of phreatic water in each period is depleted in southeast and enriched in northwest of the study area. The δ18O of confined water has an obvious spatial variation in the wet season due to the combined effects of the opencast working and underground mining, and a uniform spatial variation in the dry season. The difference in spatial variation of δ18O between phreatic and confined water may attribute to the regeneration rate, and the stable isotopic compositions in phreatic water is easier to recover than that of confined water after mining disturbance. This finding provides important information about hydrological characteristics of Pingshuo mining district.
Thermo-hydrodynamic Analysis of Journal Bearings Operating With Non-newtonian Oils
Authors: Cardoso Mateus da Silva , Salvaro Diego Berti , Klein Aloisio Nelmo , Prata Alvaro Toubes , Binder Cristiano 
Published: July 2023

Abstract

In recent years, sustainability has been one of the topics of major concern in technological progress, and reducing energy consumption is one of the biggest challenges. The refrigeration industry is responsible for about 20% of the overall electricity used worldwide. The miniaturization, mass reduction and increased rotation speeds lead to higher shear rates. In turn, at these levels, many oils may exhibit non-Newtonian behaviors. The ability to assess non-Newtonian effects can help in choosing and developing more efficient lubricants, where even small increases in efficiency can represent significant energy savings. Thus, this paper investigates the effects of using different non-Newtonian oils in a typical journal bearing of a household refrigerator compressor. For this purpose, a thermo-hydrodynamic model was proposed where the modified Reynolds equation for fluids obeying the power law coupled with the energy equation are solved using the finite volume method in an iterative process. The cavitation boundary is calculated using the equation of conservation of mass and updated at each iteration. The parameters of the power law curve fitting were obtained from experimental data fitting. The results obtained show that even for small deviations from Newtonian behavior, significant variations in load capacity and friction force can be observed. Under the same operating conditions, the load capacity and friction force are 67% and 64%, respectively, lower for the bearing operating with an alkylbenzene oil than with a polyolester oil, while the consistency parameter at To(m0) is 90% lower.
Design, Fabrication and Analysis of Soft Robotic Grippers based on Passive Layer Jamming
Authors: Li Mingge , Yin Zhongjun , Huang Xiaoming , Liu Quan 
Published: July 2023

Abstract
Soft fingers with variable stiffness based on jamming principle have the characteristics of simple structure, convenient control, and rapid response, but is usually requires vacuum pressure to squeeze the particles or layered materials to produce stiffness changes. A novel passive variable stiffness soft finger based on the passive layer jamming principle was presented in this paper. The inflation chamber of the soft finger was bent and squeezes the outer wall of the jamming chamber. The squeezing force causes the jamming layer unit inside the jamming chamber to squeeze each other to generate friction, which causes stiffness changed. Besides, aiming at the previous manufacturing methods of double-chamber soft fingers, this work also proposes an “integrated molding” casting process based on the lost-wax casting method, which can realize the manufacturing of soft fingers through on casting without splice. The experimental results shown that the soft finger with passive layer jamming also has excellent grasping performance under the condition of reducing additional equipment (vacuum system).
Effect of Probiotics on Children with Autism Spectrum Disorders: a Meta-Analysis
Authors: Zeng Ping , Zhang ChengZhi , Fan ZhiXing , Yang ChaoJun , Cai WanYin , Huang Yifan , Xiang Zujin , Wu Jingyi , Zhang Jing , Yang Jian 
Published: July 2023

Abstract
Background: Researches have found that alteration of intestinal flora may be closely related to the development of autism spectrum disorder (ASD). However, whether probiotics supplementation has a protective effect on ASD remains controversial. This meta-analysis aimed to analyze the outcome of probiotics in the treatment of ASD children.
Methods: The Pubmed, Cochrane Library, Web of Science and Embase were searched until Sep 2022. Randomized controlled trials (RCTs) relevant to the probiotics and placebo treatment on ASD children were screened. Quality assessment of the included RCTs was evaluated by the Cochrane collaboration’s tool. The primary outcomes were ASD assessment scales, including ABC (aberrant behavior checklist) and CBCL (child behavior checklist) for evaluating the behavior improvement, SRS (social responsiveness scale) for social assessment, DQ (developmental quotient) for physical and mental development and CGI-I (clinical global impression improvement) for overall improvement. The secondary outcome was total 6-GSI (gastrointestinal severity index).
Results: In total, 6 RCTs from 6 studies with 302 children were included in the systemic review. Total 6-GSI (MD=-0.59, 95%CI [-1.02,-0.17], P<0.05) decreased significantly after oral administration of probiotics. Whereas, there was no statistical difference in ABC, CBCL, SRS, DQ and CGI-I between probiotics and placebo groups in ASD children.
Conclusion: Probiotics treatment could improve gastrointestinal symptoms, but there was no significant improvement in ASD.
How does technological innovation affect the ecological footprint? Evidence from E-7 countriesin the background of the SDGs
Authors: Dam Mehmet Metin , KAYA Funda 
Published: July 2023

Abstract
This research aimed to investigated relationship among technological innovation (TI), renewable energy consumption (REC), natural resource rents (NRR), and ecological footprint (EF) of E-7 (i.e., Brazil, China, India, Indonesia, Mexico, Russia and Turkiye) countries from 1992 to 2018, to ensure environmental sustainability in the background of the Sustainable Development Goals (SDGs). The study was analyzed using the ARDL estimator, robustness test and Dumitrescu Hurlin panel causality (DHC) test. Long-term empirical estimates from the PMG-ARDL technique have shown that TI and REC reduce the EF, that is, increase environmental sustainability. At this point, it is seen that TI s and REC help in reaching SDG-7 and 13 in E-7 countries. However, on the contrary, it has been determined that NRR and real income (GDP) increase the EF. Findings were confirmed using robustness methods. In the DHC test results, while there is a unidirectional causality relationship from TI to EF, from EF to NRR and trade openness, a bidirectional causality relationship was found among GDP and EF. This study suggests that policy makers should focus on implementing environmentally friendly equipment to reduce environmental degradation, increase the share of REC and focus on sustainable development within the framework of the SDGs.