bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate analysis of prognostic factors in patients with lung cancer
Authors: Liu Changjiang , Ma Minting , Zhou Xuetao , Zhang Zefeng , Guo Yang 
Published: February 2023

ObjectiveLung cancer is the leading cause of cancer-related mortality in China. The purpose of this study was to determine the effect of non-therapeutic and therapeutic factors of patients with lung cancer on survival rate.MethodsIn this retrospective study, a total of 458 patients diagnosed as lung cancer at the Department of Thoracic Surgery, the Fourth Affiliated Hospital of Hebei Medical University from September 2008 to October 2013 were enrolled. The COX proportional hazards model was used to analyze the possible factors affecting the survival of patients. Model variables included age, sex, family history, smoking, tumor location, pathological type, stage, chemotherapy, radiotherapy, operation, and targeted therapy.ResultsThe median survival time (MST) was 32.0 months (95% CI: 29.0-34.0 months), while the 1-, 3-, and 5-year survival rates were 70.74%, 36.90%, and 30.13%, respectively. The univariate analysis showed that stage, chemotherapy, radiotherapy, and operation significantly affected the median survival time of patients. Multivariate cox regression analysis suggested that sex (female vs male, 2.096, 95% CI: 1.606-2.736), stage (stage I vs IV, 0.111, 95% CI: 0.039-0.314; stage II vs IV, 0.218, 95%CI: 0.089-0.535), chemotherapy (no vs yes, 0.469, 95% CI: 0.297-0.742), and operation (no vs yes, 2.667, 95% CI: 1.174-6.055) were independently associated with the survival of patients with lung cancer.ConclusionOur study showed that male, early stage, operation were protective factors for the survival of patients, while female, advanced stage, chemotherapy were risk factors for the survival of patients. Larger studies are required to address the usefulness of these prognostic factors in defining the management of patients with lung cancer.
Incorporating the synthetic CT image for improving the performance of deformable image registration between planning CT and cone-beam CT
Authors: Li Na , Zhou Xuanru , Chen Shupeng , Dai Jingjing , Wang Tangsheng , Zhang Chulong , He Wenfeng , Xie Yaoqin , Liang Xiaokun 
Published: February 2023

ObjectiveTo develop a contrast learning-based generative (CLG) model for the generation of high-quality synthetic computed tomography (sCT) from low-quality cone-beam CT (CBCT). The CLG model improves the performance of deformable image registration (DIR).MethodsThis study included 100 post-breast-conserving patients with the pCT images, CBCT images, and the target contours, which the physicians delineated. The CT images were generated from CBCT images via the proposed CLG model. We used the Sct images as the fixed images instead of the CBCT images to achieve the multi-modality image registration accurately. The deformation vector field is applied to propagate the target contour from the pCT to CBCT to realize the automatic target segmentation on CBCT images. We calculate the Dice similarity coefficient (DSC), 95 % Hausdorff distance (HD95), and average surface distance (ASD) between the prediction and reference segmentation to evaluate the proposed method.ResultsThe DSC, HD95, and ASD of the target contours with the proposed method were 0.87 ± 0.04, 4.55 ± 2.18, and 1.41 ± 0.56, respectively. Compared with the traditional method without the synthetic CT assisted (0.86 ± 0.05, 5.17 ± 2.60, and 1.55 ± 0.72), the proposed method was outperformed, especially in the soft tissue target, such as the tumor bed region.ConclusionThe CLG model proposed in this study can create the high-quality sCT from low-quality CBCT and improve the performance of DIR between the CBCT and the pCT. The target segmentation accuracy is better than using the traditional DIR.
Retrospective validation of G-ROP, CO-ROP, Alex-ROP, and ROPscore predictive algorithms in two Chinese medical centers
Authors: Lu Yang , Lv Zhe , Cen Jiner , Tao Jiwei , Zhang Yun , Zhang Yifan , Mao Jianbo , Chen Yiqi , Wu Mingyuan , Chen Shujun , Shen Lijun 
Published: February 2023

PurposeTo evaluate the sensitivity and specificity of four predictive algorithms (G-ROP, CO-ROP, Alex-ROP, and ROPscore) for retinopathy of prematurity and compare their performances in the Chinese population.MethodsA retrospective study was conducted at two medical centers in China of infants born at Women's Hospital School of Medicine Zhejiang University and Yiwu Maternal and Child Health Hospital. A total of 1,634 infants who met the criteria and who were GA &lt; 32 weeks or BW &lt; 2,000 g according to Chinese guidelines for ROP screening were included. The ROP group was further grouped into severe ROP and mild ROP. The sensitivity and specificity of G-ROP, two simplified G-ROPs, CO-ROP, Alex-ROP, and ROPscore were analyzed.ResultsSevere ROP and any ROP were identified in 25 and 399 of 1,634 infants, respectively. According to the criteria of different models, 844, 1,122, 1,122, and 587 infants were eligible in the G-ROP, CO-ROP, Alex-ROP, and ROPscore, respectively. G-ROP had 96.0% sensitivity and 35.0% specificity for severe ROP. For two simplified G-ROPs (180 g and 200 g models), similar sensitivity was showed with original G-ROP and they had specificity of 21.8% and 14.0%, respectively. The sensitivity and specificity of Co-ROP were 96% and 64.3% for severe ROP, while Alex-ROP only had sensitivity of 56.0% and specificity of 61.4% for severe ROP. ROPscore had a sensitivity of 91.3% and a specificity of 62.4% for severe ROP. In 546 infants who met all 4 models' inclusion criteria and included 23 infants with severe ROP, the validation outcomes showed the sensitivity of G-ROP, ROPscore, CO-ROP, and Alex-ROP for severe ROP was 95.6%, 91.3%, 100%, and 56.0%, and their specificity was 38.0%, 60.8%, 39.9%, and 52.9%, respectively.ConclusionG-ROP, ROPscore, and CO-ROP had high sensitivity for severe ROP in the Chinese population, but both the sensitivity and specificity of Alex-ROP were low. CO-ROP (not high-grade CO-ROP) provided the best performance for severe ROP in a fair comparison. For further application, ROP screening models need to be adjusted by local populations.
Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation
Authors: Guillot Bastien , Boileve Arthur , Walton Richard , Harfoush Alexandre , Conte Caroline , Sainte-Marie Yannis , Charron Sabine , Bernus Olivier , Recalde Alice , Sallé Laurent , Brette Fabien , Lezoualc’h Frank 
Published: February 2023

Introduction: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased mortality and morbidity. The Exchange Protein directly Activated by cAMP (EPAC), has been implicated in pro-arrhythmic signaling pathways in the atria, but the underlying mechanisms remain unknown.Methods: In this study, we investigated the involvement of EPAC1 and EPAC2 isoforms in the genesis of AF in wild type (WT) mice and knockout (KO) mice for EPAC1 or EPAC2. We also employed EPAC pharmacological modulators to selectively activate EPAC proteins (8-CPT-AM; 10 μM), or inhibit either EPAC1 (AM-001; 20 μM) or EPAC2 (ESI-05; 25 μM). Transesophageal stimulation was used to characterize the induction of AF in vivo in mice. Optical mapping experiments were performed on isolated mouse atria and cellular electrophysiology was examined by whole-cell patch-clamp technique.Results: In wild type mice, we found 8-CPT-AM slightly increased AF susceptibility and that this was blocked by the EPAC1 inhibitor AM-001 but not the EPAC2 inhibitor ESI-05. Consistent with this, in EPAC1 KO mice, occurrence of AF was observed in 3/12 (vs. 4/10 WT littermates) and 4/10 in EPAC2 KO (vs. 5/10 WT littermates). In wild type animals, optical mapping experiments revealed that 8-CPT-AM perfusion increased action potential duration even in the presence of AM-001 or ESI-05. Interestingly, 8-CPT-AM perfusion decreased conduction velocity, an effect blunted by AM-001 but not ESI-05. Patch-clamp experiments demonstrated action potential prolongation after 8-CPT-AM perfusion in both wild type and EPAC1 KO mice and this effect was partially prevented by AM-001 in WT.Conclusion: Together, these results indicate that EPAC1 and EPAC2 signaling pathways differentially alter atrial electrophysiology but only the EPAC1 isoform is involved in the genesis of AF. Selective blockade of EPAC1 with AM-001 prevents AF in mice.
Phylogenomics and phylogeography of Menispermum (Menispermaceae)
Authors: Song Shiqiang , Cameron Kenneth M. , Wang Yuguo , Wang Shenyi , Jin Xinjie , Hina Faiza , Yang Zhaoping , Li Pan 
Published: February 2023

IntroductionPhylogenomics have been widely used to resolve ambiguous and controversial evolutionary relationships among plant species and genera, and the identification of unique indels in plastomes may even help to understand the evolution of some plant families.MenispermumL. (Menispermaceae) consists of three species,M. dauricumDC.,M. canadenseL., andM. mexicanumRose, which are disjuncly distributed among East Asia, Eastern North America and Mexico. Taxonomists continue to debate whetherM. mexicanumis a distinct species, a variety ofM. dauricum, or simply a synonym ofM. canadense. To date, no molecular systematics studies have included this doubtful species in phylogenetic analyses.MethodsIn this study, we examined phylogenomics and phylogeography ofMenispermumacross its entire range using 29 whole plastomes of Menispermaceae and 18 ITS1&amp;ITS2 sequences of Menispermeae. We reconstructed interspecific relationships ofMenispermumand explored plastome evolution in Menispermaceae, revealing several genomic hotspot regions for the family.Results and discussionPhylogenetic and network analyses based on whole plastome and ITS1&amp;ITS2 sequences show thatMenispermumclusters into two clades with high support values, Clade A (M. dauricum) and Clade B (M. canadense+M. mexicanum). However,M. mexicanumis nested withinM. canadenseand, as a result, we support thatM. mexicanumis a synonym ofM. canadense. We also identified important molecular variations in the plastomes of Menispermaceae. Several indels and consequently premature terminations of genes occur in Menispermaceae. A total of 54 regions were identified as the most highly variable plastome regions, with nucleotide diversity (Pi) values &gt; 0.05, including two coding genes (matK,ycf1), four introns (trnK intron,rpl16intron,rps16 intron,ndhA intron), and 48 intergenic spacer (IGS) regions. Of these, four informative hotspot regions (trnH-psbA,ndhF-rpl32,trnK-rps16, andtrnP-psaJ) should be especially useful for future studies of phylogeny, phylogeography and conservation genetics of Menispermaceae.
Social support as a mediator between anxiety and quality of sleep among Chinese parents of special children
Authors: Xu Junda , Tang Jiliang 
Published: February 2023

ObjectiveThe psychological problems among Chinese parents of special children (mental retardation, limb disorder, hearing impairment, autism, cerebral palsy and other types) should be paid more attention. The aim of this study was to investigate the association between anxiety, social support, coping style and sleep quality among Chinese parents of special children during the early COVID-19 epidemic, so as to provide more help for the mental health of parents of special children scientifically and effectively.MethodA total of 305 Chinese parents of special children were invited to accomplish four questionnaires. Anxiety was measured by the Self-Rating Anxiety Scale, social support was evaluated by the Perceived Social Support Scale, sleep quality was assessed by the Pittsburgh Sleep Quality Index, and coping style was measured by the Simplified Coping Style Questionnaire.ResultsThis study revealed that anxiety was positively correlated with sleep quality (p &lt; 0.01) and negatively correlated with social support (p &lt; 0.01) and coping style (p &lt; 0.01). Sleep quality was negatively correlated with social support (p &lt; 0.01), but not significantly correlated with coping style (p &gt; 0.05). Social support was positively correlated with coping style (p &lt; 0.01). The study confirmed that social support had a partial mediating effect on the relationship between anxiety and sleep quality.ConclusionThe anxiety of parents of special children not only directly affects sleep quality, but also indirectly affects sleep quality through social support. Social support can alleviate the impact of anxiety on sleep quality through the mediating role.
Monitoring mood state to improve performance in soccer players: A brief review
Authors: Selmi Okba , Ouergui Ibrahim , Muscella Antonella , Levitt Danielle E. , Suzuki Katsuhiko , Bouassida Anissa 
Published: February 2023

IntroductionPsychological aspects of sport are key in maintaining athlete motivation and make a difference in competitive outcomes. Adjustments to training may be necessary according to athletes’ emotional state. Therefore, it is important to assess and quantify mood states throughout the season in team sports, including among soccer players. The Profile of Mood States (POMS) is a widely used questionnaire that assesses emotional states characterized by positive or negative feelings and can be administered repeatedly to assess changes in mood state. This review aims to assess and summarize the current literature on mood state variation in soccer players with a specific focus on training loads, training modalities, and competitive performance.MethodsA literature search was systematically conducted and resulted in 156 records. After removing duplicates, items with irrelevant titles and abstracts were screened out, and full texts were then screened for relevance and compared with inclusion and exclusion criteria. The remaining 37 articles were included in the final qualitative synthesis.ResultsPOMS scores were related to variability in training load, intensity of the training period, modality of training exercises, competitive performance and time of day in soccer players. Common recommendations include monitoring the mood state of soccer players during training sessions, matches, and throughout training periods to detect early signs of psychological disturbance and aid in optimizing high-level training performance.ConclusionThe POMS allows for monitoring of players’ psychological state, providing coaches with data to aid in adjusting acute program variables according to players’ psychological states and improve performance. Results offer practical support for the use of a simple POMS measurement as part of an overall program to monitor the players’ psychological states. Results also highlight how training choices (i.e., load and exercise modality) and competitive performance are related to mood states (i.e., tension, anger, confusion, depression, fatigue, and vigor).
Entrepreneurial role models and college students’ entrepreneurial calling: A moderated mediation model
Authors: Jin Dongmei , Liu Xiaomeng , Zhang Fuqin , Wen Zhiyi 
Published: February 2023

IntroductionCollege entrepreneurship education should not only cultivate a group of college students who have strong willingness to start a business immediately after graduation, but also pay attention to future entrepreneurship success of college students. Correspondingly, in addition to attaching importance to improving college students’ entrepreneurial intention, college entrepreneurship education should pay attention to improving college students’ entrepreneurial calling. At present, there is insufficient research on the association between entrepreneurial role models and entrepreneurial calling. We aim to study the mechanism and boundary condition of the association between entrepreneurial role models and entrepreneurial calling.MethodsA longitudinal survey was distributed among 519 students from 16 colleges and universities in China. In the survey, the college students answered questions on entrepreneurial role models, entrepreneurial calling, entrepreneurial perceived behavioral control and entrepreneurial hands-on practice. Hierarchical regression was conducted, testing the association between entrepreneurial role models and entrepreneurial calling of college students, mediated by entrepreneurial perceived behavioral control and moderated by entrepreneurial hands-on practice.ResultsTherefore, based on the social learning theory, the theory of planned behavior and the entrepreneurial event model, and by hierarchical regression of the data, this study confirmed that entrepreneurial role models were positively associated with college students’ entrepreneurial calling by partially mediating with entrepreneurial perceived behavioral control. Moreover, Entrepreneurial hands-on practice positively moderated not only the relationship between entrepreneurial perceived behavioral control and entrepreneurial calling, but also the mediating association of entrepreneurial perceived behavioral control between entrepreneurial role models and entrepreneurial calling.DiscussionThis study not only enriches the theoretical research on entrepreneurial calling and entrepreneurial role models, but also provides valuable educational enlightenment for colleges and universities to improve the students’ entrepreneurial calling.
The relationship between coping and distress among faculty members and students during COVID-19 pandemic lockdown: The moderating effect of gender
Authors: Hamid Abdalla A. R. M. , Miskry Abdullah Seif Abdullah Al , Darweesh Abdel Hameed M. 
Published: February 2023

ObjectivesPrevious research has documented significant associations between the COVID-19 pandemic lockdown, various mental health problems, and coping strategies. However, literature on the moderating role of gender on the relationship between distress and coping strategies during COVID-19 is almost nonexistent. Hence, the main objective of this study was two folds. To examine gender differences in distress and coping strategies, and to test the moderating effect of gender on the relationship between distress and coping among university faculty members and students during the COVID-19 pandemic.MethodA cross-sectional web-based study design was used to collect data from the participants. A sample of 649 participants (68.9% university students and 31.1% faculty members) was selected. The General Health Questionnaire (GHQ-12) and the Coping Inventory for Stressful Situations (CISS) were used to collect data from the participants. The survey was sent out during the COVID-19 lockdown from May 12th to June 30th, 2020.ResultsThe results showed significant gender differences in distress and the three coping strategies. Women consistently scored higher on distress (p &lt; 0.01), task-focused (p &lt; 0.05), emotion-focused (p &lt; 0.001), and avoidance coping (p &lt; 0.01) compared to men. Gender moderated the relationship between emotion-focused coping and distress (p &lt; 0.001) but not the relationship between distress and task-focused or avoidance coping.ConclusionIncreased emotion-focused coping is associated with decreased distress among women while the use of emotion-focused coping by men predicted more distress. Workshops and programs focused on providing skills and techniques on how to cope with stressful situations induced by the COVID-19 pandemic are recommended.
Bibliometric study on clinical research of osteoporosis in adolescents
Authors: Li Dingshuang , Ou Jingxi , Zeng Yang , Hou Lei , Yuan Yu , Luo Zhiyuan 
Published: February 2023

ObjectiveFocusing on the theme of “osteoporosis-related research in adolescents,” a systematic visualization of the developmental lineage, current research status, hot spots, and trends of adolescent osteoporosis was conducted to provide a reference for subsequent related research, clinical diagnosis, and treatment.MethodThe Web of Science core database was used as the data source to retrieve the relevant literature and the bibliometrics method. An online bibliometric platform, CiteSpace, and VOSviewer software were used to conduct co-occurrence analysis on the authors, scientific research institutions, national cooperation, keywords, and funding sources to draw the relevant knowledge map.ResultA total of 1,199 publications from the Web of Science core database were included in this study. The number of published adolescent osteoporosis (AOP) studies has shown an upward trend over the past 29 years, with the United States being the major contributor to the field with the highest number of publications (291, 24.3%) and the highest number of citations (12,186). The international collaboration map shows that the United States is the country most focused on international collaborative exchanges, with the closest collaboration between the United States and Canada. The most influential research institutions and authors are Children's Hospital and Rauch F. the United States is the primary funding source for this research area. Research hotspots were mainly focused on “bone density,” “osteoporosis,” and “children.”ConclusionThese knowledge maps review the research hotpots in adolescent osteoporosis research over time, analyze and summarize the research process over the past 29 years, and predict future research directions.
Social norms and couples' division of labor
Authors: He Shuya , Noussair Charles N. 
Published: February 2023

The COVID pandemic, which forced children to attend school remotely, compelled many couples to choose one partner to stay home to care for the children. The available evidence indicates that it is more common for women to stop working in such situations than men. In this paper, we conduct an experiment to investigate, in a controlled manner, couples' behaviors in deciding who continues to work and who quits. The design allows us to investigate the relationship between the quitting decision and social norms regarding gender roles, as well as the role of peer pressure in the decision. Participants in the experiment are real-life couples recruited for the study. Other subjects drawn from the same population serve as controls. The experimental design involves both parties undertaking a real effort task for payment. At a certain point in the session, one member of the couple must stop and the other must continue the task and earn income for the couple. We find that the couples are more likely to choose the boyfriend to continue the real-effort task for money and the girlfriend to quit the task. Framing the decision as choosing whom to “quit” working rather than whom to “continue” working has a small effect on decisions. Whether choices are revealed to their peers or not does not influence the outcome. An ancillary experiment reveals that choosing husbands to work and wives to quit the labor force is considered as the norm.JEL classificationC91, D13, J16, J22, J71.