bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of apatinib combined with liposomal doxorubicin or paclitaxel versus liposomal doxorubicin or paclitaxel monotherapy in patients with recurrent platinum‐resistant ovarian cancer
Authors: Yang Hailei , Geng Aizhi , Wang Zhenfeng , Wu Chuanzhong 
Published: March 2023

AbstractAimApatinib is an effective treatment for patients with gynecological cancers. This study aimed to further explore the efficacy and safety of apatinib plus chemotherapy in patients with recurrent platinum‐resistant ovarian cancer (PROC).MethodsTotally, 105 patients with recurrent PROC receiving apatinib plus chemotherapy (N = 51) and chemotherapy alone (N = 54) were retrospectively enrolled in this cohort study.ResultsObjective response rate (37.3% vs. 14.8%) (p = 0.009) and disease control rate (80.4% vs. 61.1%) (p = 0.030) were increased in the apatinib plus chemotherapy group versus the chemotherapy group. The median (95% confidence interval [CI]) progression‐free survival (PFS) and overall survival (OS) were 5.5 (3.4–7.6) and 21.4 (16.2–26.6) months in the apatinib plus chemotherapy group, and they were 3.8 (3.0–4.6) and 14.8 (11.9–17.7) months in the chemotherapy group. Meanwhile, the Kaplan–Meier curves revealed that PFS (p = 0.008) and OS (p = 0.012) were prolonged in the apatinib plus chemotherapy group versus the chemotherapy group. This finding was confirmed by multivariate Cox's proportional regression analyses: enter method (hazard ratio [HR] = 0.515, p = 0.007 for PFS; HR = 0.222, p < 0.001 for OS) and step‐forward method (HR = 0.608, p = 0.019 for PFS; HR = 0.346, p = 0.001 for OS). Additionally, the incidence of hypertension was increased in the apatinib plus chemotherapy group versus the chemotherapy group (p = 0.038), while others were not different between the two groups (all p > 0.05). Grades 3 and 4 adverse events were neutropenia, hypertension, leukopenia, hand–foot syndrome, nausea and vomiting, fatigue, thrombocytopenia, and anemia in the apatinib plus chemotherapy group.ConclusionApatinib combined with chemotherapy is a superior choice over chemotherapy alone for recurrent PROC management.
Double inversion recovery to detect cervical spinal cord multiple sclerosis lesions
Authors: Patel Shivam , Dimaandal Ian , Kuhns Tyler , Creed Marina , Gershon Abner , Wolansky Ivan , Imitola Jaime , Wolansky Leo 
Published: March 2023

AbstractBackground and PurposeMagnetic resonance imaging (MRI) plays a key role in diagnosing and monitoring multiple sclerosis (MS). Double inversion recovery (DIR) is a pulse sequence that has proven highly effective at detecting cortical lesions but is understudied in the spinal cord. We hypothesize that DIR images obtained during brain MRI can be of value in assessing the upper spinal cord of MS patients.MethodsWe retrospectively examined brain MRI exams of 64 patients with established MS, who had also undergone cervical spine MRI. Two blinded MS expert readers, who assessed the scans for lesion numbers and rated lesion visibility and overall image quality, reviewed brain 3‐dimensional DIR sagittal and coronal images. Standardized mean contrast‐to‐noise ratios (C/N) and standard deviation (SD) were calculated in representative lesions for each patient and compared to those of 3‐dimensional FLAIR images.ResultsFor the analysis of lesions categorized as “definite lesions,” the sensitivity was 87%, specificity was 61%, and negative predictive value was 80%. On the other hand, for “definite” plus “probable” lesions, the sensitivity was 91%, the specificity was 54%, and negative predictive value was 86%. DIR demonstrated lesions with an average C/N of 7.56 with an SD of 1.77. FLAIR sequence demonstrated lesions with an average C/N of 0.67 and SD of 1.27.ConclusionsSagittally acquired brain DIR can provide useful information on upper spinal cord lesions, with high C/N. In theory, this should facilitate the attainment of McDonald's or the Magnetic Resonance Imaging in MS (MAGNIMS) criteria in some cases, without a dedicated cervical spine MRI exam.
Effect of different span lengths with different total occlusal convergences on the accuracy of intraoral scanners
Authors: Yehia Ashraf , Abo El Fadl Ahmad , El Sergany Omar , Ebeid Kamal 
Published: March 2023

AbstractPurposeThe aim was to assess the effect of span lengths and total occlusal convergence (TOC) on the accuracy of intraoral scanners .Materials and methodsTwo typodont acrylic teeth models were prepared to receive fixed dental prostheses with three different span lengths. Span 1: between maxillary canines; span 2: between maxillary second premolars; and span 3: between maxillary second molars. In the first model, prepared teeth had a TOC of 12°, whereas, in the second model, teeth had a TOC of 20°. Each model was scanned 10 times using 4 different intraoral scanners (Omnicam, Primescan, Trios 4, and Medit i500). The STL files from the scans were compared to the reference models (trueness) and within each test group (precision) using a 3D comparison software. Data were then statistically analyzed.ResultsRegarding trueness, no significant differences were found among Primescan (32.58 ± 13.08), Trios 4 (32.33 ± 12.19), and Medit i500 (32.26 ± 9.57). However, all showed significantly better trueness than Omnicam (35.70 ± 8.35) (p < 0.001). The highest values were found in scans between the second molars (47.42 ± 3.94), followed by scans between second premolars (28.42 ± 3.78), and the highest trueness was found in scans between the canines (23.80 ± 3.85). For TOC, 12° had a significantly higher value than 20° (p < 0.001). Regarding precision, the highest values were found with Omnicam (29.84 ± 3.89), followed by Medit i500 (28.04 ± 2.94), then Trios 4 (25.64 ± 3.11), and Primescan (24.69 ± 5.25). The highest values and least precision were found in scans between the second molars (28.97 ± 5.27) and scans between second premolars (27.59 ± 3.97), whereas the highest precision was found in scans between the canines (24.60 ± 2.04). For TOC, 12° had significantly higher values than 20° (p < 0.001).ConclusionsIntraoral scans are directly affected by scanner type, TOC, and scan spans. All tested scanners showed clinically acceptable results even for long‐span restorations.
Denture stomatitis—An interdisciplinary clinical review
Authors: McReynolds David E. , Moorthy Advan , Moneley James O'Connor , Jabra‐Rizk Mary Ann , Sultan Ahmed S. 
Published: March 2023

AbstractPurposeAn interdisciplinary clinical review on denture stomatitis formulated by experts from prosthodontics, oral medicine, and oral microbiology is presented. The review outlines the etiopathogenesis, clinical features, and management strategies of denture stomatitis from an interdisciplinary perspective.Materials and methodsEnglish‐language articles relating to the definition, incidence, gender distribution, geographical distribution, etiology, pathogenesis, symptoms, signs, treatment, and prognosis of denture stomatitis were retrieved via electronic literature search. Relevant articles were summarized for this manuscript with a view toward providing pragmatic information.ResultsDenture stomatitis represents a very common, multifactorial infectious, inflammatory, and hyperplastic condition which is primarily caused by poor oral hygiene, poor denture hygiene, and full‐time; mainly night‐time denture wear, bringing about the emergence of advancedCandida‐containing polymicrobial biofilms in close proximity to the host's mucosal tissues. Denture stomatitis shares clinically relevant associations with dental caries, periodontitis, median rhomboid glossitis, angular cheilitis, aspirational pneumonia, and associated mortality.ConclusionsEffective, long‐term treatment of denture stomatitis relies upon sustained patient‐driven behavioral change which should focus on daily prosthesis‐level cleaning and disinfection, removal of dentures at night, every night, engagement with professional denture maintenance, and when required, denture replacement. Antifungal medications offer limited benefits outside of short‐term use due to the emergence of antifungal resistance. For frail, older, medically compromised, and nursing home populations, treatment of denture stomatitis lowers the risk of aspirational pneumonia and associated mortality.
The association between Aggregatibacter actinomycetemcomitansJP2 clone and periodontitis: A systematic review and meta‐analysis
Authors: Mehta Jaimini , Eaton Carolyn , AlAmri Meaad , Lin Guo‐Hao , Nibali Luigi 
Published: March 2023

AbstractTo appraise the literature on the prevalence of the JP2 clone of Aggregatibacter actinomycetemcomitans (A.a.) and on its association with presence and progression of periodontitis in different populations. A systematic search of the literature was conducted in Medline, Embase and Cochrane Library for studies reporting data on detection of the JP2 clone of A.a. A total of 56 papers were included in the review, from an initial search of 685 titles. Studies were carried out in populations with a mean age of 26.34 years (range 6.24–53.85 years). Just over 16% of the overall population assessed (n = 13 751) had the JP2 clone detected. Meta‐analyses included 16 studies and 1775 patients, and revealed an association between detection of the JP2 clone and diagnosis of periodontitis (RR = 1.86, 95% 1.43–2.42) from saliva and plaque, with high heterogeneity (I2 = 85%, p < .00001). Meta‐analyses included 5 studies and 616 patients, and revealed an association between baseline detection of the JP2 clone and onset of periodontitis over 2 to 5 years (RR = 4.12, 95% 2.42–7.00), with high heterogeneity (I2 = 81%, p < .0003). From the overall risk of bias score, 29 papers were judged as low risk of bias, whilst the remaining papers were judged to have an overall medium or high risk of bias. Detection of the JP2 clone of A.a. in subgingival plaque and saliva samples is associated with increased odds of diagnosis of periodontitis and may be able to predict onset of periodontitis. This systematic review provides clear evidence that in certain populations, the JP2 clone of A.a. is associated with early‐onset periodontitis. Furthermore, detection of this bacterium seems to be predictive of disease onset.
The ichthyofaunistic colonization and complex biogeographic history of the southern portion of the Southwest Atlantic Ocean
Authors: Figueroa Daniel E. , Barbini Santiago A. , Belleggia Mauro , Sabadin David E. , Román Jorge M. , De Wysiecki Agustín M. 
Published: March 2023

AbstractHere, we highlight the geological processes that resulted in the current conformation of the southern Southwest Atlantic Ocean, and explore the heterogeneous composition of the marine ichthyofauna found between 33° and 56° from a paleobiological perspective. During the early Cretaceous (140 Mya), the South Atlantic was still not formed, and Gondwana was probably a set of united plates with shallow continental waters. In the middle Cretaceous (112 Mya), the major Gondwanan plates started diverging from each other, allowing shallow marine intrusions and the diversification of an endemic fish fauna. By the end of the Mesozoic (66 Mya), the proto‐South Atlantic connected with the North Atlantic, which was still part of the Tethys Sea, allowing its ichthyofauna to colonize the south and reach the Antarctic region. The opening of the Drake Passage in the Oligocene (33 Mya) enabled the cold waters of the Pacific Ocean to reach the South Atlantic, causing drastic effects on the thermophilic fauna and favoring the dispersion of cold‐water species. Successive glaciations during the Quaternary (2 Myr to 10,000 years ago) resulted in the prevalence of Antarctic climatic conditions in the southern Southwest Atlantic. The long history of changing scenarios in the constitution of the southern Southwest Atlantic is reflected in the heterogeneous composition of the marine ichthyofauna between 33° and 56°S, which is characterized by a mixture of cosmopolitan, Tethyan, Pacific, Gondwanan, Antarctic, and endemic origins.
A Hungarian Theologian Abroad: The Reception of the Lima Document in the Works of Gellért Békés OSB (1915–1999)
Authors: Kisnémet OSB Fülöp 
Published: March 2023

AbstractThis article aims to provide an insight into the ecumenical work of a Hungarian Benedictine monk, Gellért Békés. First, I offer a short overview of Békés's life, who was forced into exile by the socialist regime and who spent almost half a century as Professor at the University of Saint Anselm in Rome. Next, I review Békés's publications and the main thrust of his thinking in the field of ecumenical theology. The central part of my article is devoted to the presentation of his Italian monograph (Eucaristia e chiesa, 1985), which can be considered to be his most important work and in which he gives a comprehensive account of his ecumenical theology of the Eucharist, especially in the light of the Lima Document of 1982. His major contribution lies in the fact that he took into account the interrelation between the various ecumenical documents and he integrated the newly retrieved dimensions of the Eucharist. He also commented on the idea of Real Presence developed by the Lima Document in the light of Catholic doctrine. Last but not least, this article wants to contribute to the reception of Békés's thought, which has hardly begun even in his own country.
Allergen‐free extracts from birch, ragweed, and hazel pollen activate human and guinea‐pig submucous and spinal sensory neurons
Authors: Buhner Sabine , Schäuffele Stefanie , Giesbertz Pieter , Demir Ihsan Ekin , Zeller Florian , Traidl‐Hoffmann Claudia , Schemann Michael , Gilles Stefanie 
Published: March 2023

AbstractBackgroundNon‐allergenic, low molecular weight components of pollen grains are suspected to trigger changes in gut functions, sometimes leading to inflammatory conditions. Based on extensive neuroimmune communication in the gut wall, we investigated the effects of aqueous pollen extracts (APE) on enteric and spinal sensory neurons.MethodsUsing Ca2+ and fast potentiometric imaging, we recorded the responses of guinea‐pig and human submucous and guinea‐pig dorsal root ganglion (DRG) neurons to microejection of low (<3 kDa) and high (≥3 kDa) molecular weight APEs of birch, ragweed, and hazel. Histamine was determined pharmacologically and by mass spectrometry (LC–MS/MS).Key ResultsBirch APE<3kDa evoked strong [Ca+2]i signals in the vast majority of guinea‐pig DRG neurons, and in guinea‐pig and human enteric neurons. The effect of birch APE≥3kDa was much weaker. Fast neuroimaging in human enteric neurons revealed an instantaneous spike discharge after microejection of birch, ragweed, and hazel APE<3kDa [median (interquartile range) at 7.0 Hz (6.2/9.8), 5.7 Hz (4.4/7.1), and 8.4 Hz (4.3/12.5), respectively]. The percentage of responding neurons per ganglion were similar [birch 40.0% (33.3/100.0), ragweed 50.8% (34.4/85.6), and hazel 83.3% (57.1/100.0)]. A mixture of histamine receptor (H1–H3) blockers significantly reduced nerve activation evoked by birch and ragweed APEs<3kDa, but was ineffective on hazel. Histamine concentrations in ragweed, birch and hazel APE's < 3 kDa were 0.764, 0.047, and 0.013 μM, respectively.ConclusionsAllergen‐free APEs from birch, ragweed, and hazel evoked strong nerve activation. Altered nerve‐immune signaling as a result of severe pollen exposure could be a pathophysiological feature of allergic and non‐allergic gut inflammation.
Clinical characteristics and long‐term outcomes in patients with cyclic vomiting syndrome: A 15‐year experience at a tertiary referral center
Authors: Partovi Omeed , Patel Milan , Kovacic Katja , Petrova Ana , Garacchi Zhuping , Venkatesan Thangam 
Published: March 2023

AbstractBackgroundCyclic vomiting syndrome (CVS) is a disorder of gut–brain interaction (DGBI) characterized by recurrent episodes of nausea and vomiting. Most children outgrow their CVS symptoms and develop migraine headaches, but there are limited data in adults. We thus sought to determine the natural history of CVS in adults.MethodsWe conducted a retrospective analysis of patients at a specialized tertiary care clinic. Frequency of CVS episodes, emergency department (ED) visits, and hospitalizations were recorded at the index visit and at follow‐up.Key ResultsOf 455 CVS patients with complete data, mean age was 33 ± 13 years, 294 (65%) were female, and 392 (86%) were Caucasian. Mean duration of follow‐up was 47.4 ± 37.2 months. There was a significant reduction in frequency of CVS episodes/year (18 to 6.8), ED visits (6.1 to 2), and hospitalizations (2.3 to 0.7) (allp‐values < 0.001) but only 88 (19%) of patients had complete resolution of episodes at follow‐up. On multivariable regression analysis, non‐white race [0.33 (0.11–0.98)p = 0.01], comorbidity count [0.77 (0.62–0.95)p = 0.01], cannabis use [0.36 (0.2–0.65)p = 0.0007], and aprepitant use [0.2 (0.08–0.005)p < 0.001] were associated with a reduced odds of complete resolution of CVS episodes. Of note, 19 patients (4%) died.Conclusions and InferencesWhile most adults with CVS improved with specialized care, in contrast to children, only a small subset (~1 in 5) had complete resolution of symptoms. Reasons for the effects of race, cannabis use, and comorbidity burden on outcomes in CVS are unclear and warrant further investigation.
The epidemiology and impact of disorders of gut–brain interaction in Canada: Results from the Rome Foundation Global Epidemiologic Study
Authors: Rodrigues David M. , Poitras Pierre , Day Andrew G. , Sperber Ami D. , Palsson Olafur , Bangdiwala Shrikant I. , Vanner Stephen J. 
Published: March 2023

AbstractBackgroundUsing data from the Rome Foundation Global Epidemiology Study examining prevalence of disorders of gut–brain interaction (DGBI) in 33 countries, this study explored the prevalence of all 22 disorders in Canada. It examined differences related to geography and sociodemographic factors, health impact and compared these findings to other countries.MethodsThe Rome Foundation survey was conducted through the Internet, targeting 2000 Canadian participants. The survey used the validated ROME IV diagnostic questionnaire to identify the 22 DGBI and an in‐depth supplemental questionnaire that included quality assurance techniques.Key ResultsThere were 2029 respondents with a mean age of 48 years and 50% females. Diagnostic criteria for at least one of the 22 DGBI were met by 41.3%, similar to other countries. Functional constipation, functional diarrhea, and unspecified functional bowel disorders were most common. Irritable bowel syndrome prevalence was 4.2% using Rome IV and 10.1% using ROME III criteria. DGBI were associated with poorer quality of life and increased psychological symptom scores. Prevalence of DGBI ranged from 48% in Quebec to 36% in British Columbia. Prescription pain medication was reported by 17% with DGBI compared to 9% without DGBI and correlated negatively with mental health and physical well‐being. Quebecers and francophones were in limited number but reported higher DGBI prevalence and symptom severity compared to others.Conclusions & InferencesA large proportion of Canadians suffer from DGBI which seriously impact their well‐being. Findings highlight the need for further research and education, including understanding whether significant regional and cultural differences contribute to DGBI.
Acclimation of photosynthetic capacity and foliar respiration in Andean tree species to temperature change
Authors: Cox Andrew J. F. , Hartley Iain P. , Meir Patrick , Sitch Stephen , Dusenge Mirindi Eric , Restrepo Zorayda , González‐Caro Sebastian , Villegas Juan Camilo , Uddling Johan , Mercado Lina M. 
Published: March 2023

Summary
Climate warming is causing compositional changes in Andean tropical montane forests (TMFs). These shifts are hypothesised to result from differential responses to warming of cold‐ and warm‐affiliated species, with the former experiencing mortality and the latter migrating upslope. The thermal acclimation potential of Andean TMFs remains unknown.
Along a 2000 m Andean altitudinal gradient, we planted individuals of cold‐ and warm‐affiliated species (under common soil and irrigation), exposing them to the hot and cold extremes of their thermal niches, respectively. We measured the response of net photosynthesis (Anet), photosynthetic capacity and leaf dark respiration (Rdark) to warming/cooling, 5 months after planting.
In all species, Anet and photosynthetic capacity at 25°C were highest when growing at growth temperatures (Tg) closest to their thermal means, declining with warming and cooling in cold‐affiliated and warm‐affiliated species, respectively. When expressed at Tg, photosynthetic capacity and Rdark remained unchanged in cold‐affiliated species, but the latter decreased in warm‐affiliated counterparts. Rdark at 25°C increased with temperature in all species, but remained unchanged when expressed at Tg.
Both species groups acclimated to temperature, but only warm‐affiliated species decreased Rdark to photosynthetic capacity ratio at Tg as temperature increased. This could confer them a competitive advantage under future warming.
MPK12 in stomatal CO2 signaling: function beyond its kinase activity
Authors: Yeh Chung‐Yueh , Wang Yuh‐Shuh , Takahashi Yohei , Kuusk Katarina , Paul Karnelia , Arjus Triinu , Yadlos Oleksii , Schroeder Julian I. , Ilves Ivar , Garcia‐Sosa Alfonso T. , Kollist Hannes 
Published: March 2023

Summary

Protein phosphorylation is a major molecular switch involved in the regulation of stomatal opening and closure. Previous research defined interaction between MAP kinase 12 and Raf‐like kinase HT1 as a required step for stomatal movements caused by changes in CO2 concentration. However, whether MPK12 kinase activity is required for regulation of CO2‐induced stomatal responses warrants in‐depth investigation.

We apply genetic, biochemical, and structural modeling approaches to examining the noncatalytic role of MPK12 in guard cell CO2 signaling that relies on allosteric inhibition of HT1.

We show that CO2/HCO3−‐enhanced MPK12 interaction with HT1 is independent of its kinase activity. By analyzing gas exchange of plant lines expressing various kinase‐dead and constitutively active versions of MPK12 in a plant line where MPK12 is deleted, we confirmed that CO2‐dependent stomatal responses rely on MPK12's ability to bind to HT1, but not its kinase activity. We also demonstrate that purified MPK12 and HT1 proteins form a heterodimer in the presence of CO2/HCO3− and present structural modeling that explains the MPK12:HT1 interaction interface.

These data add to the model that MPK12 kinase‐activity‐independent interaction with HT1 functions as a molecular switch by which guard cells sense changes in atmospheric CO2 concentration.
Business, power, and private regulatory governance: Shaping subjectivities and limiting possibilities in the gold supply chain
Authors: Bloomfield Michael John , Manchanda Nivi 
Published: March 2023

AbstractTo examine how private regulatory governance reproduces a market logic that always already circumscribes possibilities for radical change, we tarry with Michel Foucault's notion of governmentality and his writings on power. We focus on two major initiatives created to regulate gold supply chains, subjecting their publicly released documents to a discourse analysis. This reveals subtle but tangible examples of how these initiatives discursively shape business preferences and possibilities for engaging with a social change agenda. Through a focus on how power circulating through these initiatives works to shape the identities and interests of business actors themselves, we contribute a new perspective to the literature on business, power, and private regulatory governance, one that highlights the ways through which these discourses both expand and limit business actors' engagement in setting social agendas and the mixed and sometimes seemingly contradictory implications for the public interest.