bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cobblestone‐like brain malformation with a new bi‐allelic ADGRG1 (GPR‐56) mutation: Fetal imaging‐pathology correlation
Authors: Izzo Giana , Toto Valentina , Faiola Stefano , Cattaneo Elisa , Cavallari Ugo , Passarini Alice , Gladin Caroline Regna , Scelsa Barbara , Parazzini Cecilia , Righini Andrea 
Published: June 2023

AbstractBackground and PurposeAutosomal recessive cobblestone‐like cortical malformation of the brain, with no eye or muscle involvement, has been reported in patients with biallelic mutations in ADGRG1 (formerly GPR56) and in other brain surface defects (eg, variants in COL3A1). We reported the intra‐uterine brain MRI (iu‐MRI), post‐mortem MRI (pm‐MRI), and neuropathology findings of a new ADGRG1 mutation in a fetus at early gestation. Imaging findings were compared with those of the sibling harboring the same mutation, to provide insights about the evolving morphology of such malformation.MethodsA 21‐week fetus underwent iu‐MRI for a suspected cortical anomaly on ultrasound. After the MRI results, the termination of the pregnancy was carried out. A pm‐MRI scan and autopsy were performed. A neuropathology‐imaging correlation was achieved. The 5‐year old sibling affected by developmental impairment also underwent a brain MRI. Both subjects underwent a genetic investigation.ResultsTwo patterns of abnormality of the cerebral surface were identified on both fetal MRI: one at the vertex resembling a cobblestone‐cortex due to neuronal overmigration into the subarchnoid space and the other in the occipital areas resembling polymicrogyria. These details closely matched the neuropathology findings. MRI findings of the sibling consisted of typical ADGRG1/GPR56‐related brain findings showing a polymicrogyric‐like cortex, also reported as bilateral frontal‐parietal polymicrogyria. A flattened pons and small cerebellar vermis were present in both cases.Genetic testing demonstrated a novel homozygous variant c.1484T>C in the c gene in both cases.ConclusionOur findings provide further evidence of the overlap of ADGRG1/GPR56‐related brain dysgenesis with cobblestone‐like cortical malformation of the brain.
“DNAsignaturing” database construction forTetradesmusspecies identification and phylogenetic relationships ofScenedesmus‐like green microalgae (Scenedesmaceae, Chlorophyta)
Authors: Mai Xuan Cuong , Shen Chia‐Rui , Liu Chao‐Lin , Trinh Dang Mau , Nguyen Minh Ly 
Published: June 2023

AbstractSpecies identification ofScenedesmus‐like microalgae, comprisingDesmodesmus,Tetradesmus, andScenedesmus, has been challenging due to their high morphological and genetic similarity. After developing a DNA signaturing tool forDesmodesmusidentification, we built a DNA signaturing database forTetradesmus. The DNA signaturing tool contained species‐specific nucleotide sequences ofTetradesmusspecies or strain groups with high similarity in ITS2 sequences. To construct DNA signaturing, we collected data on ITS2 sequences, aligned the sequences, organized the data by ITS2 sequence homology, and determined signature sequences according to hemi‐compensatory base changes (hCBC)/CBC data from previous studies. FourTetradesmusspecies and 11 strain groups had DNA signatures. The signature sequence of the genusTetradesmus, TTA GAG GCT TAA GCA AGG ACCC, recognized 86% (157/183) of the collectedTetradesmusstrains. Phylogenetic analysis ofScenedesmus‐like species revealed that theTetradesmusspecies were monophyletic and closely related to each other based on branch lengths.Desmodesmuswas suggested to split into two subgenera due to their genetic and morphological distinction.Scenedesmusmust be analyzed along with other genera of the Scenedesmaceae family to determine their genetic relationships. Importantly, DNA signaturing was integrated into a database for identifyingScenedesmus‐like species through BLAST.
Full‐length transcriptome sequencing and transgenic tobacco revealed the key genes in the chlorogenic acid synthesis pathway of Sambucus chinensis L.
Authors: Chen Min , Xiao Mu , Liu Boyu , Wang Man , Tan Chengfang , Zhang Yi , Quan Hui , Ruan Ying , Huang Yong 
Published: June 2023

AbstractChlorogenic acid is a key chemical in antioxidation and antisepsis. Sambucus chinensis L. is an herbaceous plant rich in chlorogenic acid and a potential genetic resource for breeding high‐chlorogenic acid plants. However, there are few studies on the synthesis pathway of chlorogenic acid in S. chinensis. Our study found chlorogenic acid accumulation in S. chinensis to be organ‐specific, higher in leaves and buds but lower in roots, stems and fruits. A total number of 546,844 CCS (circular consensus sequence), including 402,767 full‐length nonchimeric (FLNC) and 39 annotated sequences related to the synthesis of chlorogenic acid, was obtained by single‐molecule real‐time sequencing technology (SMRT). qRT‐PCR showed that a number of key genes involved in chlorogenic acid synthesis were differentially expressed in various tissues of S. chinensis. Transgenic tobacco revealed that ectopic expression of the HCT homologous gene HCT‐45178 increased the content of chlorogenic acid. Our results should be the first report of full‐length transcriptome data of S. chinensis, which help to understand the basis of chlorogenic acid synthesis and provide a novel strategy for breeding tobacco cultivars with higher levels of chlorogenic acid.
Alt‐right gangs and far‐right extremists: From the margins to the mainstream
Authors: Valasik Matthew , Reid Shannon E. 
Published: June 2023

AbstractThe continued public presence of far‐right groups, particularly alt‐right gangs (e.g., Proud Boys) participating in mass demonstrations and protests across the United States has made it clear that these groups and their behavior remain a concern. The overall lack of knowledge among policy makers, law enforcement, and community residents on how to deal with alt‐right gang members has limited their ability to intervene and prevent violence. The misconception that alt‐right gangs are domestic terrorist organizations, primarily driven by racist ideology, ignores just how unrefined and rudimentary the beliefs that connect members together actually are. The reliance on ideology has limited the inclusion of alt‐right gangs in conventional gang studies and has directly impacted gang scholars' ability to understand group dynamics among these far‐right gangs. This has in turned skewed also how law enforcement is trained to identify and deal with alt‐right gangs. This manuscript overviews the need to rectify the historical apathy of traditional gang scholars and law enforcement in dealing with far‐right/alt‐right gangs. We conclude with a discussion on how the mainstreaming of alt‐right groups over the last few years has accelerated and the growing need to explicitly treat these groups as street gangs.
Transversals in quasirandom latin squares
Authors: Eberhard Sean , Manners Freddie , Mrazović Rudi 
Published: June 2023

AbstractA transversal in an latin square is a collection of entries not repeating any row, column, or symbol. Kwan showed that almost every latin square has transversals as . Using a loose variant of the circle method we sharpen this to . Our method works for all latin squares satisfying a certain quasirandomness condition, which includes both random latin squares with high probability as well as multiplication tables of quasirandom groups.
Use and persistence of single and multiple inhaler triple therapy prescribed for patients with COPD in France: a retrospective study on THIN database (OPTI study)
Authors: Deslee Gaétan , Fabry-Vendrand Caroline , Poccardi Nolwenn , Thabut Gabriel , Eteve Pitsaer Caroline , Coriat Adrien , Renaudat Charlotte , Maguire Andrew , Pinto Thomas 
Published: June 2023

IntroductionFrom 2018 single inhaler triple therapy (SITT) became available in France to treat moderate-to-severe chronic obstructive pulmonary disease (COPD). Given its simplified inhaler use compared with multiple inhaler triple therapy (MITT), this therapeutic option has the potential to offer benefit in terms of improved persistence and adherence. Given the lack of real-world evidence of the effectiveness of triple therapy, this study was designed to evaluate the use of MITT and SITT in France and compare persistence.MethodsA retrospective cohort study was performed. Patients with COPD who initiated triple therapy between 1 July 2017 and 31 December 2019 were included from The Health Improvement Network, a large electronic medical database in France, which includes pharmacy data. A 60-day treatment gap defined discontinuation and thereby persistence.ResultsA total of 3134 patients initiated triple therapy for COPD in the study period, among them 485 with SITT. In 2019, the rate of use of SITT was 28.2%. The mean age (67.3 years) and sex (44.2% female) of patients initiating triple therapy was similar between MITT and SITT, and most patients had escalated from dual therapy (84.1%). However, SITT was more frequently initiated by a pulmonologist (59.8%) and a higher prevalence of comorbid asthma was observed for SITT (47.0% vs 37.9%). Persistence was assessed among patients who did not discontinue after a single dispensation of triple therapy (n=1674). Median persistence was 181 days for SITT and 135 days for MITT, and the covariate-adjusted HR for persistence was 1.47 (p<0.001) and the estimated persistence at 1 year was 33% for SITT compared with 18% for MITT.DiscussionThis study suggests that persistence was higher for the patients treated with SITT compared with MITT in France. Moreover, most patients initiated with triple therapy were previously treated with dual therapy and had exacerbations in the previous year.
STRASSE: a silicon tracker for quasi-free scattering measurements at the RIBF
Authors: Liu H. N. , Flavigny F. , Baba H. , Boehmer M. , Bonnes U. , Borshchov V. , Doornenbal P. , Ebina N. , Enciu M. , Frotscher A. , Gernhäuser R. , Girard-Alcindor V. , Goupillière D. , Heuser J. , Kapell R. , Kondo Y. , Lee H. , Lehnert J. , Matsui T. , Matta A. , Nakamura T. , Obertelli A. , Pohl T. , Protsenko M. , Sasano M. , Satou Y. , Schmidt C. J. , Schünemann K. , Simons C. , Sun Y. L. , Tanaka J. , Togano Y. , Tomai T. , Tymchuk I. , Uesaka T. , Visinka R. , Wang H. , Wienholtz F. 
Published: June 2023

AbstractSilicon Tracker for RAdioactive nuclei Studies at SAMURAI Experiments is a new detection system under construction for quasi-free scattering (QFS) measurements at 200–250 MeV/nucleon at the RIBF facility of the RIKEN Nishina Center. It consists of a charged-particle silicon tracker coupled with a dedicated thick liquid hydrogen target (up to 150-mm long) in a compact geometry to fit inside large scintillator or germanium arrays. Its design was optimized for two types of studies using QFS: missing-mass measurements and in-flight prompt $$\gamma $$
γ
-ray spectroscopy. This article describes (i) the resolution requirements needed to go beyond the sensitivity of existing systems for these two types of measurements, (ii) the conceptual design of the system using detailed simulations of the setup and (iii) its complete technical implementation and challenges. The final tracker aims at a sub-mm reaction vertex resolution and is expected to reach a missing-mass resolution below 2 MeV in $$\sigma $$
σ
for (p, 2p) reactions when combined with the CsI(Na) CATANA array.
Exclusive photoproduction of $$B_{c}^{\pm }$$ and bottomonia pairs
Authors: Andrade Sebastián , Siddikov Marat , Schmidt Iván 
Published: June 2023

AbstractIn this paper we analyze the photoproduction of heavy quarkonia pairs which include b-quarks, such as $$B_{c}^{+}B_{c}^{-}$$

B

c

+

B

c

-

-mesons or charmonium-bottomonium pairs. Compared to charmonia pair production, these channels get contributions only from some subsets of diagrams, and thus allow for a better theoretical understanding of different production mechanisms. In contrast to the production of hidden-flavor quarkonia, for the production of $$B_{c}$$

B
c

-meson pairs there are no restrictions on internal quantum numbers in the suggested mechanisms. Using the Color Glass Condensate approach, we estimated numerically the production cross-sections in the kinematics of the future electron–hadron colliders and the ultraperipheral collisions at LHC. We found that the production of $$J/\psi \,\eta _{c}$$

J
/
ψ

η
c

and $$B_{c}^{+}B_{c}^{-}$$

B

c

+

B

c

-

meson pairs are the most promising channels for studies of quarkonia pair production.
A tectonic solution for the Early Cambrian palaeogeographical enigma
Authors: Keppie Duncan Fraser , Keppie John Duncan , Landing Ed 
Published: June 2023

Abstract

The Early Cambrian palaeogeographical enigma arises when tectonic reconstructions are made using palaeoclimatic v. palaeomagnetic data that result in possibly contradictory tropical, mid-latitude, and south polar locations for major continents. For example, NW Africa and Cadomia may have lain in a tropical zone (0° to ±30° latitude) based on the presence of archaeocyath reefs, minor evaporites, and carbonate platforms at
c.
520 Ma ± 5 Ma or, alternatively, NW Africa and Cadomia may have lain in a south polar zone (90° to 60° south latitude) based on palaeomagnetic constraints. Greater Avalonia may have evolved independently from NW Africa if a dropstone constraint implying polar latitudes at
c.
530 Ma and a palaeomagnetic constraint implying
c.
50° latitude at
c.
505 Ma are accommodated. We show here how counterclockwise rotation of Gondwana during the Cambrian about an interior axis may solve the enigma. Gondwanan apparent polar wander becomes consistent with tropical conditions inferred for NW Africa when adjusted to accommodate constraints placing the south pole near Peru for
c.
540–520 Ma. Concurrent counterclockwise rotation of Baltica and Gondwana during the Middle Cambrian may have facilitated separation of Greater Avalonia from Baltica across dextral shear zones.
Design of Novel Ultrabroadband Printed Antenna and Its Efficient Optimization Using Self-Adaptive Hybrid Differential Evolution Algorithm
Authors: Gao Tian-Ye , Jiao Yong-Chang , Zhang Yi-Xuan 
Published: June 2023

A novel compact ultra-broadband-modified fork-shaped printed antenna is optimized efficiently by using a self-adaptive hybrid differential evolution (SHDE) algorithm. Firstly, a novel compact ultra-broadband-modified fork-shaped printed antenna structure is proposed. The antenna with more compact size consists of a modified fork-shaped radiator and a modified ground plane, which can cover a very wide operating frequency band. The antenna is fed by a step-shaped microstrip line, and the modified ground plane consists of some rectangular slots and an L-shaped stub. Then, the SHDE algorithm is used to determine structural dimensions of the proposed antenna, and the antenna’s performance is optimized while maintaining a cost-effective computation time. The optimized antenna with only

11.8

mm
×
19.7

mm

size covers -10 dB reflection coefficient bandwidth of 147.6% from 3.08 to 20.46 GHz. Finally, the antenna prototype is fabricated, and the measured results basically agree with the simulated ones. The proposed antenna can be viewed as an excellent candidate for realizing ultrabroadband transmission technology.
Data from Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Authors: Gonzalez Nicole , Rao Nina , Dean Michael , Lee Donghyuk , Hurson Amber N. , Baris Dalsu , Schwenn Molly , Johnson Alison , Prokunina-Olsson Ludmila , Friesen Melissa C. , Zhu Bin , Rothman Nathaniel , Silverman Debra T. , Koutros Stella 
Published: June 2023

<div>AbstractBackground:<p>Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors.</p>Methods:<p>Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures.</p>Results:<p>We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, nonmuscle invasive <i>TP53</i>-mutated tumors compared with controls [OR<sub>Top Tertile vs.Unexposed</sub>, 4.8; 95% confidence interval (CI), 2.2–10.5; <i>P</i><sub>trend</sub> < 0.001; <i>P</i><sub>heterogeneity</sub> = 0.002]. In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR, 1.93; 95% CI, 1.28–2.92) and 3-nitrobenzoic acid (RR, 1.97; 95% CI, 1.33–2.92).</p>Conclusions:<p>The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of <i>TP53</i> mutations in tumors, further supporting the link between PAH exposure and <i>TP53</i> mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer.</p>Impact:<p>This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer.</p></div>
Redefining Expertise and Evidence in Global Implementation Research
Authors: Vedham Vidya , Parascandola Mark , Gravitt Patti E. 
Published: June 2023

Abstract
The theme for the 11th Annual Symposium on Global Cancer Research, co-convened with partners by the U.S. NCI Center for Global Health is “Closing the Research-to-Implementation Gap.” Here, we reflect on the evolving role of implementation science from the lens of the needs of low- and middle-income countries. We highlight the importance for stronger and sustained engagement of implementation scientists and cancer control and prevention practitioners to enable more context-relevant co-design of implementation plans and strategies. We argue that deep learning from embedded implementation research through inductive analytic approaches is a critical first step to acceleration of evidence-to-practice translation and suggest an important role for systems approaches to facilitate this transition.
Data from Multicenter Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for <i>IDH1</i>-Mutated Acute Myeloid Leukemia
Authors: Fathi Amir T. , Kim Haesook T. , Soiffer Robert J. , Levis Mark J. , Li Shuli , Kim Annette S. , DeFilipp Zachariah , El-Jawahri Areej , McAfee Steve L. , Brunner Andrew M. , Amrein Philip C. , Mims Alice S. , Knight Laura W. , Kelley Devon , Bottoms AJ S. , Perry Lindsey H. , Wahl Jonathan L. , Brock Jennifer , Breton Elayne , Marchione Dylan M. , Ho Vincent T. , Chen Yi-Bin 
Published: June 2023

<div>AbstractPurpose:<p>Isocitrate dehydrogenase 1 (<i>IDH1</i>) mutations occur in 5% to 10% of patients with acute myeloid leukemia (AML). Ivosidenib is an IDH1 inhibitor, approved for use in patients with <i>IDH1</i>-mutated AML.</p>Patients and Methods:<p>We conducted a multicenter, phase I trial of maintenance ivosidenib following allogeneic hematopoietic cell transplantation (HCT) in patients with <i>IDH1</i>-mutated AML. Ivosidenib was initiated between days 30 and 90 following HCT and continued for up to 12 28-day cycles. The first dose level was 500 mg daily, with level reduction to 250 mg daily, if needed, in a 3 × 3 de-escalation design. Ten additional patients would then receive the MTD or recommended phase 2 dose (RP2D). The primary endpoint was establishing the MTD or RP2D of ivosidenib.</p>Results:<p>Eighteen patients were enrolled, of whom 16 initiated post-HCT ivosidenib. One dose-limiting toxicity, grade(g) 3 QTc prolongation, was observed. The RP2D was established at 500 mg daily. Attributable g≥3 adverse events were uncommon, with the most common being QTc prolongation in 2 patients. Eight patients discontinued maintenance, with only one due to adverse event. Six-month cumulative incidence (CI) of gII-IV aGVHD was 6.3%, and 2-year CI of all cGVHD was 63%. Two-year CI of relapse and nonrelapse mortality (NRM) were 19% and 0%, respectively. Two-year progression-free (PFS) was 81%, and 2-year overall survival (OS) was 88%.</p>Conclusions:<p>Ivosidenib is safe and well-tolerated as maintenance therapy following HCT. Cumulative incidence of relapse and NRM, as well as estimations of PFS and OS, were promising in this phase I study.</p></div>
Abstract 21: Clinical Trials in Gastroesophageal Cancers: An Analysis of the Global Landscape of Interventional Trials From ClinicalTrials.gov
Authors: Falade Ayo , Adeoye Oluwatayo , Buckle Geoffrey 
Published: June 2023

Abstract
Purpose: This study aims to describe the global landscape of clinical research into interventions for gastroesophageal (GE) cancers, which are a leading cause of cancer morbidity and mortality worldwide. We examine trial characteristics, focusing on geographic distribution of trial sites, participation of low-and-middle-income countries (LMICs), and factors associated with premature trial termination.
Methods: We queried ClinicalTrials.gov database to identify all completed or terminated Phase III interventional studies investigating GE cancers (esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastroesophageal junctional (GEJ) and gastric adenocarcinoma). All reported characteristics were extracted. Pearson’s chi-square and Fisher’s exact test were used to compare differences in completed and terminated trials. Multivariate logistic regression was used to determine predictors of termination.
Results: A total of 179 trials were identified; 90% were therapeutic. Most included sites in Asia (61%), Europe (32%), and North America (23%); few included sites in South America (9%), Africa (4%), and Oceania (9%). 63% of trials included high-income countries (HICs) sites alone; only 7% included sites in lower-middle or low-income countries. Most (70%) focused exclusively on gastric or GEJ adenocarcinoma, 13% on EAC and ESCC, and 9% ESCC alone. 16% (n=29) of trials terminated, most due to accrual difficulties (n=13, 44%). In multivariate analysis, study site number, location, and eligible patient population emerged as predictors of termination. Trials conducted exclusively in the US were more likely to terminate (OR 7.22 [95% CI 1.59-32.69]). Conversely, trials conducted exclusively in LMICs were less likely to terminate (OR 0.04 [95% CI 0.01-0.59] v conducted in HIC alone). Studies on ESCC were more likely to terminate (OR 17.74 [95%CI 1.49-210.69]). Trial design characteristics, intervention characteristics, and funding sources were not associated with termination.
Conclusion: Although 80% of GE malignancies occur in LMICs, trial activity disproportionately occurs in HICs. Few trials focus on EAC/ESCC despite being highly fatal, highlighting an unmet need. Geographic location of trial sites emerged as a predictor of trial termination, with studies involving LMICs sites less likely to terminate prematurely. This finding highlights the potential benefit of including LMICs in future clinical trials to advance research for these diseases.
Citation Format: Ayo Falade, Oluwatayo Adeoye, Geoffrey Buckle. Clinical Trials in Gastroesophageal Cancers: An Analysis of the Global Landscape of Interventional Trials From ClinicalTrials.gov [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 21.