bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of West Nile Virus in the Northeastern United States Using Negative Binomial and Mechanistic Trait‐Based Models
Authors: Keyel Alexander C. 
Published: April 2023

AbstractWest Nile virus (WNV) primarily infects birds and mosquitoes but has also caused over 2,000 human deaths, and >50,000 reported human cases in the United States. Expected numbers of WNV neuroinvasive cases for the present were described for the Northeastern United States, using a negative binomial model. Changes in temperature‐based suitability for WNV due to climate change were examined for the next decade using a temperature‐trait model. WNV suitability was generally expected to increase over the next decade due to changes in temperature, but the changes in suitability were generally small. Many, but not all, populous counties in the northeast are already near peak suitability. Several years in a row of low case numbers is consistent with a negative binomial, and should not be interpreted as a change in disease dynamics. Public health budgets need to be prepared for the expected infrequent years with higher‐than‐average cases. Low‐population counties that have not yet had a case are expected to have similar probabilities of having a new case as nearby low‐population counties with cases, as these absences are consistent with a single statistical distribution and random chance.
Optical Insight Into Riverine Influences on Dissolved and Particulate Organic Carbon in a Coastal Arctic Lagoon System
Authors: Catipovic L. , Longnecker K. , Okkonen S. R. , Koestner D. , Laney S. R. 
Published: April 2023

AbstractArctic coastal margins receive organic material input from rivers, melted sea ice, and coastal erosion, phenomena that are all undergoing changes related to global climate. The optical properties of coastal Arctic waters contain information on this organic material, and we examined three optical properties of seawater (absorption, backscatter, and fluorescence) for their relationships to variability in dissolved and particulate organic carbon (DOC and POC) in Stefansson Sound, Alaska, a coastal Arctic embayment. During open water periods in 2018 and 2019, DOC was inversely correlated with salinity (r2 = 0.97) and positively correlated with dissolved organic matter fluorescence (fDOM; r2 = 0.67). DOC showed strong correlation with the nonparticulate absorption coefficient at 440 nm (ag(440)) only in 2018 (r2 = 0.95). The vertical structure of fDOM in Stefansson Sound aligned with density profiles more strongly in 2018 than in 2019, and higher levels of fDOM, ag(440), and backscatter seen near the bottom in 2019 suggest wind‐driven mixing and/or bottom resuspension events. In both years, DOC correlated strongly with the spectral slope of the absorption coefficient between 412 and 550 nm (r2 = 0.70), and POC was well correlated with spectral backscattering at 470, 532, and 660 nm (r2 = 0.90, 0.71, and 0.59). These interannual differences in the spatial and vertical distributions of DOC and POC, and their respective correlations with optical proxies, likely reflect regional climatological factors such as precipitation over the adjacent watersheds, wind patterns, and residual sea ice in late summer.
SLF/ELF Fields From VED Solved by Normalized Spherical Harmonic Functions
Authors: Liang PengFei , Di QingYun , Fu Changmin , Chen Wenxuan , Zhang Wenxiu 
Published: April 2023

AbstractElectromagnetic (EM) fields excited by a vertical electric dipole (VED) at the super‐low frequency and the extremely low frequency have been widely used in different studies such as space weather, earthquake predictions, geophysical investigations, and communications. Accurate and efficient algorithms are necessary for quick estimations of worldwide EM fields. This study proposes a recursive algorithm to calculate EM fields excited by a VED embedded in a layered spherical model. A set of local/general reflection and transmission coefficients is defined to describe propagations of EM fields in each spherical layer and the outgoing‐type waves and the standing‐type waves of EM fields are expressed by normalized spherical Bessel/Hankel functions. The normalized spherical Bessel/Hankel functions are not only useful to overcome the overflow problem in calculations of spherical Bessel/Hankel functions but also helpful to speed up the convergence of summation expressions of EM fields, because the normalized spherical Bessel/Hankel functions mitigate small oscillations terms. Calculating the primary fields and the secondary fields of the total EM fields, respectively, is also helpful to reach convergent summations, because their convergence radiuses are different.
Investigating the potential anti-depressive mechanisms of statins: a transcriptomic and Mendelian randomization analysis
Authors: Jiang Jiayue-Clara , Hu Chenwen , McIntosh Andrew M. , Shah Sonia 
Published: April 2023

AbstractObservational studies and randomized controlled trials presented inconsistent findings on the effects of cholesterol-lowering statins on depression. It therefore remains unclear whether statins have any beneficial effects on depression, and if so, what the underlying molecular mechanisms are. Here, we aimed to use genomic approaches to investigate this further. Using Connectivity Map (CMap), we first investigated whether statins and antidepressants shared pharmacological effects by interrogating gene expression responses to drug exposure in human cell lines. Second, using Mendelian randomization analysis, we investigated both on-target (through HMGCR inhibition) and potential off-target (through ITGAL and HDAC2 inhibition) causal effects of statins on depression risk and depressive symptoms, and traits related to the shared biological pathways identified from CMap analysis. Compounds inducing highly similar gene expression responses to statins in HA1E cells (indicated by an average connectivity score with statins > 90) were found to be enriched for antidepressants (12 out of 38 antidepressants; p = 9E-08). Genes perturbed in the same direction by both statins and antidepressants were significantly enriched for diverse cellular and metabolic pathways, and various immune activation, development and response processes. MR analysis did not identify any significant associations between statin exposure and depression risk or symptoms after multiple testing correction. However, genetically proxied HMGCR inhibition was strongly associated with alterations in platelets (a prominent serotonin reservoir) and monocyte percentage, which have previously been implicated in depression. Genetically proxied ITGAL inhibition was strongly associated with basophil, monocyte and neutrophil counts. We identified biological pathways that are commonly perturbed by both statins and antidepressants, and haematological biomarkers genetically associated with statin targets. Our findings warrant pre-clinical investigation of the causal role of these shared pathways in depression and potential as therapeutic targets, and investigation of whether blood biomarkers may be important considerations in clinical trials investigating effects of statins on depression.
Carbonate system in the Cabo Frio upwelling
Authors: Silva Carlos Augusto Ramos e , de Godoy Fernandes Livia Viana , de Souza Flavo Elano Soares , Marotta Humberto , da Costa Fernandes Flavio , Mello Thaise Machado Senez , Monteiro Nicole Silva Caliman , Rocha Anderson Araújo , Coutinho Ricardo , de Almeida Fernandes Lohengrin Dias , Damasceno Raimundo Nonato , dos Santos Ludmila Caetano 
Published: April 2023

AbstractThe quantitative assessment of the carbonate system represents one of the biggest challenges toward the "Sustainable Development Goals" defined by the United Nations in 2015. In this sense, the present study investigated the Spatio-temporal dynamics of the carbonate system and the effects of the El Niño and La Niña phenomena over the Cabo Frio upwelling area. The physical characterization of the site was carried out through data on wind speed and sea surface temperature. Water samples were also collected during the oceanographic cruise onboard the Diadorim R/V (Research Vessel). From these samples, the parameters of absolute and practical salinity, density, pH, total alkalinity, carbonate, calcite, aragonite, bicarbonate dissolved inorganic carbon, carbon dioxide, partial pressure of carbon, calcium, and total boron were obtained. The highest average concentration of bicarbonate in S1 (2018 µmol/kg) seems to contribute to the dissolved inorganic carbon values (2203 µmol/kg). The values of calcite saturation state, aragonite saturation state, and carbonate were higher on the surface of each station (calcite saturation state = 4.80–5.48; aragonite saturation state = 3.10–3.63, and carbonate = 189–216 µmol/kg). The mean values of pH were similar in the day/night samples (7.96/7.97). The whole carbonate system was calculated through thermodynamic modeling with the Marine Chemical Analysis (AQM) program loaded with the results of the following parameters: temperature, salinity, total alkalinity, and pH parameters. This manuscript presents original data on the carbonate system and the "acidification" process influenced by the Cabo Frio upwelling, which directly depends on the El Niño and La Niña phenomena oscillations in the sea surface temperature.
High-dimensional spatiotemporal visual analysis of the air quality in China
Authors: Liu Jia , Wan Gang , Liu Wei , Li Chu , Peng Siqing , Xie Zhuli 
Published: April 2023

AbstractAir quality is a significant environmental issue among the Chinese people and even the global population, and it affects both human health and the Earth’s long-term sustainability. In this study, we proposed a multiperspective, high-dimensional spatiotemporal data visualization and interactive analysis method, and we studied and analyzed the relationship between the air quality and several influencing factors, including meteorology, population, and economics. Six visualization methods were integrated in this study, each specifically designed and improved for visualization analysis purposes. To reveal the spatiotemporal distribution and potential impact of the air quality, we designed a comprehensive coupled visual interactive analysis approach visually express both high-dimensional and spatiotemporal attributes, reveal the overall situation and explain the relationship between attributes. We clarified the current spatiotemporal distribution, development trends, and influencing factors of the air quality in China through interactive visual analysis of a 25-dimensional dataset involving 31 Chinese provinces. We also verified the correctness and effectiveness of relevant policies and demonstrated the advantages of our method.
Risk taking for potential losses but not gains increases with time of day
Authors: Bedder Rachel L. , Vaghi Matilde M. , Dolan Raymond J. , Rutledge Robb B. 
Published: April 2023

AbstractHumans exhibit distinct risk preferences when facing choices involving potential gains and losses. These preferences are believed to be subject to neuromodulatory influence, particularly from dopamine and serotonin. As neuromodulators manifest circadian rhythms, this suggests decision making under risk might be affected by time of day. Here, in a large subject sample collected using a smartphone application, we found that risky options with potential losses were increasingly chosen over the course of the day. We observed this result in both a within-subjects design (N = 2599) comparing risky options chosen earlier and later in the day in the same individuals, and in a between-subjects design (N = 26,720) showing our effect generalizes across ages and genders. Using computational modelling, we show this diurnal change in risk preference reflects a decrease in sensitivity to increasing losses, but no change was observed in the relative impacts of gains and losses on choice (i.e., loss aversion). Thus, our findings reveal a striking diurnal modulation in human decision making, a pattern with potential importance for real-life decisions that include voting, medical decisions, and financial investments.
Charge-optimized many-body interaction potential for AlN revisited to explore plasma–surface interactions
Authors: Gergs Tobias , Mussenbrock Thomas , Trieschmann Jan 
Published: April 2023

AbstractPlasma–surface interactions during AlN thin film sputter deposition could be studied by means of reactive molecular dynamics (RMD) methods. This requires an interaction potential that describes all species as well as wall interactions (e.g., particle emission, damage formation) appropriately. However, previous works focused on the establishment of AlN bulk potentials. Although for the third-generation charge-optimized many-body (COMB3) potential at least a single reference surface was taken into account, surface interactions are subject to limited reliability only. The demand for a revised COMB3 AlN potential is met in two steps: First, the Ziegler–Biersack–Littmark potential is tapered and the variable charge model QTE$$^{+}$$

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is implemented to account for high-energy collisions and distant charge transport, respectively. Second, the underlying parameterization is reworked by applying a self-adaptive evolution strategy implemented in the GARFfield software. Four wurtzite, three zinc blende and three rock salt surfaces are considered. An example study on the ion bombardment induced particle emission and point defect formation reveals that the revised COMB3 AlN potential is appropriate for the accurate investigation of plasma–surface interactions by means of RMD simulations.
A new phase model of the spatiotemporal relationships between three circadian oscillators in the brainstem
Authors: Ahern Jake , Chrobok Łukasz , Champneys Alan R. , Piggins Hugh D. 
Published: April 2023

AbstractAnalysis of ex vivo Per2 bioluminescent rhythm previously recorded in the mouse dorsal vagal complex reveals a characteristic phase relationship between three distinct circadian oscillators. These signals represent core clock gene expression in the area postrema (AP), the nucleus of the solitary tract (NTS) and the ependymal cells surrounding the 4th ventricle (4Vep). Initially, the data suggests a consistent phasing in which the AP peaks first, followed shortly by the NTS, with the 4Vep peaking 8–9 h later. Wavelet analysis reveals that this pattern is not consistently maintained throughout a recording, however, the phase dynamics strongly imply that oscillator interactions are present. A simple phase model of the three oscillators is developed and it suggests that realistic phase dynamics occur between three model oscillators with coupling close to a synchronisation transition. The coupling topology suggests that the AP bidirectionally communicates phase information to the NTS and the 4Vep to synchronise the three structures. A comparison of the model with previous experimental manipulations demonstrates its feasibility to explain DVC circadian phasing. Finally, we show that simulating steadily decaying coupling improves the model’s ability to capture experimental phase dynamics.
Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia
Authors: Boyer Cierra K. , Bauchle Casey J. , Zhang Jianchao , Wang Yanzhuang , Stephens Samuel B. 
Published: April 2023

AbstractThe pancreatic islet β-cell’s preference for release of newly synthesized insulin requires careful coordination of insulin exocytosis with sufficient insulin granule production to ensure that insulin stores exceed peripheral demands for glucose homeostasis. Thus, the cellular mechanisms regulating insulin granule production are critical to maintaining β-cell function. In this report, we utilized the synchronous protein trafficking system, RUSH, in primary β-cells to evaluate proinsulin transit through the secretory pathway leading to insulin granule formation. We demonstrate that the trafficking, processing, and secretion of the proinsulin RUSH reporter, proCpepRUSH, are consistent with current models of insulin maturation and release. Using both a rodent dietary and genetic model of hyperglycemia and β-cell dysfunction, we show that proinsulin trafficking is impeded at the Golgi and coincides with the decreased appearance of nascent insulin granules at the plasma membrane. Ultrastructural analysis of β-cells from diabetic leptin receptor deficient mice revealed gross morphological changes in Golgi structure, including shortened and swollen cisternae, and partial Golgi vesiculation, which are consistent with defects in secretory protein export. Collectively, this work highlights the utility of the proCpepRUSH reporter in studying proinsulin trafficking dynamics and suggests that altered Golgi export function contributes to β-cell secretory defects in the pathogenesis of Type 2 diabetes.
Rat model of attention-deficit hyperactivity disorder exhibits delayed recovery from acute incisional pain due to impaired descending noradrenergic inhibition
Authors: Suto Takashi , Kato Daiki , Koibuchi Ikuya , Arai Yuki , Ohta Jo , Hiroki Tadanao , Obata Hideaki , Saito Shigeru 
Published: April 2023

AbstractChronic pain and attention-deficit hyperactivity disorder (ADHD) frequently coexist. However, the common pathology is still unclear. Attenuated noradrenergic endogenous analgesia can produce acute pain chronification, and dysfunction of noradrenergic systems in the nervous system is relevant to ADHD symptoms. Noxious stimuli-induced analgesia (NSIA) is measured to estimate noradrenergic endogenous analgesia in spontaneously hypertensive rats (SHR) as an ADHD model and control. Recovery of pain-related behaviors after paw incision was assessed. Contributions of noradrenergic systems were examined by in vivo microdialysis and immunohistochemistry. The SHR showed attenuated NSIA and needed a more extended period for recovery from acute pain. These results suggest ADHD patients exhibit acute pain chronification due to pre-existing attenuated noradrenergic endogenous analgesia. Immunohistochemistry suggests abnormal noradrenaline turnover and downregulation of the target receptor (alpha2a adrenoceptor). Standard ADHD treatment with atomoxetine restored NSIA and shortened the duration of hypersensitivity after the surgery in the SHR. NSIA protocol activated the locus coeruleus, the origin of spinal noradrenaline, of both strains, but only the control exhibited an increase in spinal noradrenaline. This result suggests dysfunction in the noradrenaline-releasing process and can be recognized as a novel mechanism of attenuation of noradrenergic endogenous analgesia.
Development and validation of machine learning-based clinical decision support tool for identifying malnutrition in NICU patients
Authors: Yalçın Nadir , Kaşıkcı Merve , Çelik Hasan Tolga , Demirkan Kutay , Yiğit Şule , Yurdakök Murat 
Published: April 2023

AbstractHospitalized newborns have an increased risk of malnutrition and, especially preterm infants, often experience malnutrition-related extrauterine growth restriction (EUGR). The aim of this study was to predict the discharge weight and the presence of weight gain at discharge with machine learning (ML) algorithms. The demographic and clinical parameters were used to develop the models using fivefold cross-validation in the software-R with a neonatal nutritional screening tool (NNST). A total of 512 NICU patients were prospectively included in the study. Length of hospital stay (LOS), parenteral nutrition treatment (PN), postnatal age (PNA), surgery, and sodium were the most important variables in predicting the presence of weight gain at discharge with a random forest classification (AUROC:0.847). The AUROC of NNST-Plus, which was improved by adding LOS, PN, PNA, surgery, and sodium to NNST, increased by 16.5%. In addition, weight at admission, LOS, gestation-adjusted age at admission (> 40 weeks), sex, gestational age, birth weight, PNA, SGA, complications of labor and delivery, multiple birth, serum creatinine, and PN treatment were the most important variables in predicting discharge weight with an elastic net regression (R2 = 0.748). This is the first study on the early prediction of EUGR with promising clinical performance based on ML algorithms. It is estimated that the incidence of EUGR can be improved with the implementation of this ML-based web tool (http://www.softmed.hacettepe.edu.tr/NEO-DEER/) in clinical practice.
Microvascular and structural analysis of the retina and choroid in heart failure patients with reduced ejection fraction
Authors: Khalilipur Ehsan , Mahdizad Zahra , Molazadeh Negin , Faghihi Hooshang , Naderi Nasim , Mehrabi Bahar Mohammadreza , Firouzi Ata , Sadeghipour Parham , Maleki Majid , Soltani Shahgoli Sahel , Khalili Pour Elias , Riazi-Esfahani Hamid 
Published: April 2023

AbstractThis cross-sectional study was designed to assess alterations of choroidal and retinal microvasculature in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and compare them with a normal age and sex-matched population. Fifty-two eyes of 26 patients with HFrEF (left ventricular ejection fraction [LVEF] < 40%) and 64 eyes of 32 healthy individuals were considered as the patient and the control groups, respectively. We found no statistically significant differences in age-adjusted mean central macular thickness (CMT), superficial or deep retinal capillary plexus vascular densities, and choriocapillaris flow (CC flow) density between the HFrEF group and the normal controls, with the exception of the parafoveal mean superficial capillary plexus vascular density (P = 0.023), which remained statistically significant after adjusting for age (P = 0.034). The patients with HFrEF had a significantly lower subfoveal choroidal thickness (SFCT) than the normal subjects (264 ± 82 vs 313 ± 72; P = 0.009), and the difference was still statistically significant after age adjustment (P = 0.026). Although choroidal vascularity index (CVI) was lower in the HFrEF group than in the control group, the difference was not statistically significant before and after age adjustment (73.45 ± 6.67 vs 75.77 ± 5.92; P = 0.118 and P = 0.096, respectively). In conclusion, in patients with HFrEF, we observed a reduction in parafoveal retinal VD in the superficial capillary plexus, as well as SFCT, but no significant change in CVI, CMT, or CC flow density.