bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of automatic speech recognition in ESL/EFL pronunciation: A meta-analysis
Authors: Thi-Nhu Ngo Thuy , Hao-Jan Chen Howard , Kuo-Wei Lai Kyle 
Published: April 2023

AbstractThis meta-analytic study explores the overall effectiveness of automatic speech recognition (ASR) on ESL/EFL student pronunciation performance. Data with 15 studies representing 38 effect sizes found from 2008 to 2021 were meta-analyzed. The findings of the meta-analysis indicated that ASR has a medium overall effect size (g = 0.69). Results from moderator analyses suggest that (1) ASR with explicit corrective feedback is largely effective, while ASR with indirect feedback (e.g. ASR dictation) is moderately effective; (2) ASR has a large effect on segmental pronunciation but a small effect on suprasegmental pronunciation; (3) medium to long treatment duration of ASR results in higher learning outcomes, but short duration offers no differential effect compared to a non-ASR condition; (4) practicing pronunciation with peers in an ASR condition produces a large effect, but the effect is small when practicing alone; (5) ASR is largely effective for adult (i.e. 18 years old and above) and intermediate English learners. Overall, ASR is a beneficial application and is recommended for assisting L2 student pronunciation development.
Public health by organizational fix?
Authors: Weale Albert , Hunter David J. , Littlejohns Peter , Khatun Toslima , Johnson Jacqueline 
Published: April 2023

AbstractIn August 2020 the UK government announced without warning the abolition of Public Health England (PHE), the principal UK agency for the promotion and protection of public health. We undertook a research programme seeking to understand the factors surrounding this decision. While the underlying issues are complex two competing interpretations have emerged: an ‘official’ explanation, which highlights the failure of PHE to scale up its testing capacity in the early weeks of the COVID-19 pandemic as the fundamental reason for closing it down and a ‘sceptical’ interpretation, which ascribes the decision to blame-avoidance behaviour on the part of leading government figures. This paper reviews crucial claims in these two competing explanations exploring the arguments for and against each proposition. It concludes that neither is adequate and that the inability adequately to address the problem of testing (which triggered the decision to close PHE) lies deeper in the absence of the norms of responsible government in UK politics and the state. However our findings do provide some guidance to the two new organizations established to replace PHE to maximize their impact on public health. We hope that this information will contribute to the independent national COVID inquiry.
Goosegrass (Eleusine indica) resistant to multiple herbicide modes of action in Brazil
Authors: Araújo Lucas da Silva , Correia Núbia Maria , Tornisielo Valdemar Luiz , Labate Mônica Teresa Veneziano , Tsai Siu Mui , Carbonari Caio Antônio , Filho Ricardo Victoria 
Published: April 2023

AbstractThis study was developed based on a goosegrass [Eleusine indica (L.) Gaertn.] population from Primavera do Leste, MT, Brazil, with resistance to multiple herbicide modes of action (5-enolpyruvylshikimate-3-phosphate synthase [EPSPS] inhibition: glyphosate; acetyl-coenzyme A carboxylase [ACCase] inhibition: aryloxyphenoxypropionate chemical group). The objective was to identify possible mechanisms of resistance associated or not with herbicide sites of action. Several experiments and analyses were carried out with the contribution of different laboratories and institutions. The results obtained allowed us to conclude that: (1) the Asp-2078-Gly mutation conferred resistance to ACCase inhibitors, without overexpression of ACCase or changes in herbicide absorption and translocation; (2) overexpression of EPSPS, Thr-102 and Pro-106 mutations, and changes in absorption and translocation are not involved in E. indica resistance to glyphosate; (3) the metabolism of glyphosate in resistant E. indica plants requires further studies to elucidate the final destination of this herbicide in these plants. The mechanism of resistance of E. indica biotypes to ACCase-inhibiting herbicides was elucidated: it involves a change in the action site. However, the mechanism of resistance to EPSPS inhibitors was not conclusive, indicating that some hypotheses, mainly those regarding the metabolism of glyphosate in resistant plants, require further testing.
Long‐Living Earthquake Swarm and Intermittent Seismicity in the Northeastern Tip of the Noto Peninsula, Japan
Authors: Amezawa Y. , Hiramatsu Y. , Miyakawa A. , Imanishi K. , Otsubo M. 
Published: April 2023

AbstractThe factors controlling earthquake swarm duration are remain unclear, especially in the long‐living ones. A severe earthquake swarm struck the tip of the Noto peninsula, Japan. Ten M > 4.0 earthquakes occurred, and the sequence has continued more than 4 years. We investigated the spatiotemporal characteristics of the swarm using relocated hypocenters to elucidate the factors causing this long duration. The swarm consists of four seismic clusters—northern, northeastern, western, and southern—the latter of which began first. Diffusive hypocenter migrations were observed in the western, northern, and northeastern clusters with moderate to low diffusivities, implying a low‐permeability environment. Rapid diffusive migration associated with intermittent seismicity deep within the southern cluster suggests the presence of a highly pressurized fluid supply. We conclude that the nature of this fluid supply combined with intermittent seismicity from the southern cluster and a low‐permeability environment are the key causes of this long‐living swarm.
Measurements of Stratospheric Water Vapor at Mauna Loa and the Effect of the Hunga Tonga Eruption
Authors: Nedoluha Gerald E. , Gomez R. Michael , Boyd Ian , Neal Helen , Allen Douglas R. , Lambert Alyn , Livesey Nathaniel J. 
Published: April 2023

AbstractThe eruption of Hunga Tonga in January 2022 injected an amount of water vapor into the stratosphere that is unprecedented in the satellite era. In the ensuing months Aura Microwave Limb Sounder measurements showed that this plume of water vapor spread from its original injection site at 20.5°S to Mauna Loa, Hawaii at 19.5°N, where an increase was observed in April by the ground‐based Water Vapor Millimeter‐wave Spectrometer instruments. Interannual variations in water vapor occur over Mauna Loa due to both dynamical variations in the tropical stratosphere and variations in the amount of water vapor crossing the tropical tropopause, and we place the observed stratospheric water vapor increase from Hunga Tonga into context of these other variations that have been observed since 2013.
JEDI‐Based Three‐Dimensional Ensemble‐Variational Data Assimilation System for Global Aerosol Forecasting at NCEP
Authors: Huang Bo , Pagowski Mariusz , Trahan Samuel , Martin Cory R. , Tangborn Andrew , Kondragunta Shobha , Kleist Daryl T. 
Published: April 2023

AbstractA three‐dimensional ensemble‐variational global aerosol data assimilation system based on the Joint Effort for Data assimilation Integration (JEDI) was developed for the Global Ensemble Forecast System‐Aerosols (GEFS‐Aerosols) coupled with the Goddard Chemistry Aerosol Radiation and Transport (GOCART) model at the National Centers for Environmental Prediction. Aerosol mass mixing ratios in GEFS‐Aerosols were selected as control or analysis variables and were adjusted by assimilating 550 nm Aerosol Optical Depth (AOD) retrievals from the Visible Infrared Imaging Radiometer Suite (VIIRS) instruments onboard the Suomi National Polar‐orbiting Partnership (S‐NPP) satellite produced by the National Environmental Satellite, Data, and Information Service (NESDIS) at National Oceanic and Atmospheric Administration (NOAA). The original NOAA/NESDIS S‐NPP VIIRS Level 2.0 550 nm AOD retrievals were converted to JEDI Interface for Observation Data Access format. AOD forward operator and its tangent‐linear and adjoint models were implemented based on GOCART in JEDI Unified Forward Operator. A stochastically perturbed emission (SPE) approach was developed in the Common Community Physics Package‐based GEFS‐Aerosols to account for aerosol emission uncertainty. One‐month retrospective and three‐month near‐real‐time experiments consistently showed improved GEFS‐Aerosols analyses and forecasts from assimilating VIIRS 550 nm AOD retrievals against independent NASA Aqua and Terra Moderate Resolution Imaging Spectroradiometer AOD retrievals, Aerosol Robotic Network AOD, and independent AOD and aerosol analyses from NASA and European Centre for Medium‐Range Weather Forecasts. Through scaling and perturbing aerosol emissions, SPE enhanced ensemble error‐spread consistency and further improved AOD assimilation. The valid‐time‐shifting ensemble approach in a cost‐effective manner of populating background ensembles showed positive impacts on AOD assimilation.
A Comparison of Arctic Ocean Sea Ice Export Between Nares Strait and the Canadian Arctic Archipelago
Authors: Howell S. E. L. , Babb D. G. , Landy J. C. , Moore G. W. K. , Montpetit B. , Brady M. 
Published: April 2023

AbstractNares Strait and the channels of the Canadian Arctic Archipelago (CAA) act as conduits for sea ice export from the Arctic Ocean but have never been directly compared. Here, we perform such a comparison for both the sea ice area and volume fluxes from October 2016 to December 2021. Nares Strait provided the largest average seasonal (October through September) ice area flux of 95 ± 8 × 103 km2 followed by the CAA regions of the Queen Elizabeth Islands (QEI) at 41 ± 7 × 103 km2 and M’Clure Strait at 2 ± 8 × 103 km2 with corresponding ice volume fluxes of 177 ± 15 km3, 59 ± 10 km3, and 8 ± 8 km3, respectively. Larger Arctic Ocean ice export at Nares Strait was associated with a shorter ice arch duration (237 days) compared to M’Clure Strait (163 days) and QEI (65 days). Seasonal Arctic Ocean ice export was dominated by Nares Strait in 2017–2019 and 2021 but was remarkably exceeded by the QEI in 2020. Large‐scale atmospheric circulation patterns were found to influence the ice area flux in the absence of ice arches but no occurrence of coherent Arctic Ocean ice export events coinciding across all gates were observed. Average net seasonal Arctic Ocean ice area and volume export were 138 × 103 km2 and 245 km3, which represent ∼16% of the area and ∼25% of the volume of sea ice export from Fram Strait. Divergent Arctic Ocean export ice trajectories are apparent for Nares Strait and the QEI when compared to Fram Strait.
Adherence in Young People Living With Juvenile Arthritis: A Systematic Review
Authors: Nelson Cecelia I. , Noel Destiny , Caes Line , McCabe Klanci M. , Duncan Christina L. 
Published: April 2023

Objective: Juvenile idiopathic arthritis (JIA) is one of the leading causes of chronic pain in pediatric patients. Treatment regimens, which are critical to symptom management, can be burdensome, involving medication with potentially aversive side effects and exercise that can cause joint pain. Thus, it is important to examine the barriers and facilitators to adherence in JIA. While systematic reviews exist for rheumatic disease in adults, there has not yet been a synthesis of the literature examining adherence in JIA. Methods: PsychINFO, PubMed, and MEDLINE databases were systematically searched to identify qualitative and quantitative empirical studies that investigate adherence to JIA. Keywords included: “patient compliance” OR “adherence” OR “persistence”; “youth” OR “children” OR “juvenile” OR “pediatric” OR “teen” OR “child” OR “adolescent”; and “rheumatoid arthritis” OR “idiopathic arthritis” OR “arthritis.” Articles were excluded from the review if they involved nonhuman or adult samples, were nonexperimental (e.g., practice recommendations), were not peer-reviewed, or were not written in English. After abstract selection, 32 articles were included in the analyses. Results: Adherence to exercise regimens was consistently lower than adherence to medication. Researchers relied heavily on self-report of adherence, which suggests a need for additional research with more objective measures of adherence. Across studies, psychological treatment was not included, so adherence to this treatment component in JIA remains understudied. Conclusions: Results suggest that future research should target devising and evaluating interventions to improve adherence to exercise and perhaps psychological treatment. Implications for Impact Statement To facilitate adherence to JIA, behavioral health providers should focus on building a strong therapeutic alliance between provider and child, fostering positive coping skills in parents and children, and monitoring the parent–child relationship.
The Impact of COVID-19 on Emotional, Social, and Behavioral Health in Adolescents With Preexisting Mental Health Concerns: A Qualitative Study
Authors: Sobalvarro Sarah S. , Cepeda Javier A. , Garcia Janelle T. , Jackson Cate , Shiang Evelyn , Chakravarti Sachiv , Workman Jacob , Reese Jasmine M. 
Published: April 2023

Objective: The COVID-19 pandemic has caused a decline in well-being for many adolescents. However, the impact of COVID-19 on mental health outcomes among adolescents remains understudied. The current study qualitatively examined the impact of COVID-19 restrictions on adolescents with mental health concerns prior to the pandemic. Methods: We enrolled 20 adolescents who were engaged in care through an Adolescent Health Specialty Clinic prior to COVID-19. Participants were 12- to 19 years old who experienced mental health concerns prior to COVID-19 and experienced declining mental health (e.g., new mental health diagnosis or increased severity of previous mental health diagnosis reported during clinical visit or documented in medical chart) during the pandemic. In-depth interviews were conducted, and inductive coding was applied to transcripts to identify emergent themes. Results: Five key themes were identified: manifestations of declining mental health, loss of motivation, changes to social relationships, use of social media, and coping mechanisms. Adverse mental health outcomes were provoked by experiences of loneliness and social isolation, especially due to school closures which disrupted routines, access to educational and social support, and key cultural milestones. The increased uses of social media and illicit substances were notable coping strategies. Conclusions: Findings from this study strengthen our understanding of the key factors influencing the psychosocial well-being of adolescents during the pandemic. Our results may help inform researchers, clinicians, and policymakers to develop guidelines and community-based strategies for mitigating the potentially negative effects of future pandemic-related disruptions to mental health among adolescents. Implications for Impact Statement The current study examined the impact of COVID-19 restrictions on adolescents with mental health concerns prior to the pandemic. Results emphasize the importance of obtaining first-hand perspectives from adolescents to optimize their care. Providers should prioritize mental health and substance use screening given the impact of the pandemic.
RIPK1 inhibition contributes to lysosomal membrane stabilization in ischemic astrocytes via a lysosomal Hsp70.1B-dependent mechanism
Authors: Du Hua-ping , Guo Yi , Zhu Yong-ming , Gao De-fei , Lin Bo , Liu Yuan , Xu Yuan , Said Ali , Khan Taous , Liu Li-jun , Zhu Jian-jun , Ni Yong , Zhang Hui-ling 
Published: April 2023

AbstractReceptor-interacting protein kinase 1 (RIPK1) contributes to necroptosis. Our previous study showed that pharmacological or genetic inhibition of RIPK1 protects against ischemic stroke-induced astrocyte injury. In this study, we investigated the molecular mechanisms underlying RIPK1-mediated astrocyte injury in vitro and in vivo. Primary cultured astrocytes were transfected with lentiviruses and then subjected to oxygen and glucose deprivation (OGD). In a rat model of permanent middle cerebral artery occlusion (pMCAO), lentiviruses carrying shRNA targeting RIPK1 or shRNA targeting heat shock protein 70.1B (Hsp70.1B) were injected into the lateral ventricles 5 days before pMCAO was established. We showed that RIPK1 knockdown protected against OGD-induced astrocyte damage, blocked the OGD-mediated increase in lysosomal membrane permeability in astrocytes, and inhibited the pMCAO-induced increase in astrocyte lysosome numbers in the ischemic cerebral cortex; these results suggested that RIPK1 contributed to the lysosomal injury in ischemic astrocytes. We revealed that RIPK1 knockdown upregulated the protein levels of Hsp70.1B and increased the colocalization of Lamp1 and Hsp70.1B in ischemic astrocytes. Hsp70.1B knockdown exacerbated pMCAO-induced brain injury, decreased lysosomal membrane integrity and blocked the protective effects of the RIPK1-specific inhibitor necrostatin-1 on lysosomal membranes. On the other hand, RIPK1 knockdown further exacerbated the pMCAO- or OGD-induced decreases in the levels of Hsp90 and the binding of Hsp90 to heat shock transcription factor-1 (Hsf1) in the cytoplasm, and RIPK1 knockdown promoted the nuclear translocation of Hsf1 in ischemic astrocytes, resulting in increased Hsp70.1B mRNA expression. These results suggest that inhibition of RIPK1 protects ischemic astrocytes by stabilizing lysosomal membranes via the upregulation of lysosomal Hsp70.1B; the mechanism underlying these effects involves decreased Hsp90 protein levels, increased Hsf1 nuclear translocation and increased Hsp70.1B mRNA expression.
A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine
Authors: Hermansen Johanne U. , Yin Yanping , Urban Aleksandra , Myklebust Camilla V. , Karlsen Linda , Melvold Katrine , Tveita Anders A. , Taskén Kjetil , Munthe Ludvig A. , Tjønnfjord Geir E. , Skånland Sigrid S. 
Published: April 2023

AbstractThe microenvironment of chronic lymphocytic leukemia (CLL) cells in lymph nodes, spleen, and bone marrow provides survival, proliferation, and drug resistance signals. Therapies need to be effective in these compartments, and pre-clinical models of CLL that are used to test drug sensitivity must mimic the tumor microenvironment to reflect clinical responses. Ex vivo models have been developed that capture individual or multiple aspects of the CLL microenvironment, but they are not necessarily compatible with high-throughput drug screens. Here, we report on a model that has reasonable associated costs, can be handled in a regularly equipped cell lab, and is compatible with ex vivo functional assays including drug sensitivity screens. The CLL cells are cultured with fibroblasts that express the ligands APRIL, BAFF and CD40L for 24 h. The transient co-culture was shown to support survival of primary CLL cells for at least 13 days, and mimic in vivo drug resistance signals. Ex vivo sensitivity and resistance to the Bcl-2 antagonist venetoclax correlated with in vivo responses. The assay was used to identify treatment vulnerabilities and guide precision medicine for a patient with relapsed CLL. Taken together, the presented CLL microenvironment model enables clinical implementation of functional precision medicine in CLL.
Unusual double ligand holes as catalytic active sites in LiNiO2
Authors: Huang Haoliang , Chang Yu-Chung , Huang Yu-Cheng , Li Lili , Komarek Alexander C. , Tjeng Liu Hao , Orikasa Yuki , Pao Chih-Wen , Chan Ting-Shan , Chen Jin-Ming , Haw Shu-Chih , Zhou Jing , Wang Yifeng , Lin Hong-Ji , Chen Chien-Te , Dong Chung-Li , Kuo Chang-Yang , Wang Jian-Qiang , Hu Zhiwei , Zhang Linjuan 
Published: April 2023

AbstractDesigning efficient catalyst for the oxygen evolution reaction (OER) is of importance for energy conversion devices. The anionic redox allows formation of O-O bonds and offers higher OER activity than the conventional metal sites. Here, we successfully prepare LiNiO2with a dominant 3d8Lconfiguration (Lis a hole at O 2p) under high oxygen pressure, and achieve a double ligand holes 3d8L2under OER since one electron removal occurs at O 2porbitals for NiIIIoxides. LiNiO2exhibits super-efficient OER activity among LiMO2,RMO3(M = transition metal,R = rare earth) and other unary 3d catalysts. Multiple in situ/operando spectroscopies reveal NiIII→NiIVtransition together with Li-removal during OER. Our theory indicates that NiIV(3d8L2) leads to direct O-O coupling between lattice oxygen and *O intermediates accelerating the OER activity. These findings highlight a new way to design the lattice oxygen redox with enough ligand holes created in OER process.
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
Authors: Heazlewood Shen Y. , Ahmad Tanveer , Cao Benjamin , Cao Huimin , Domingues Melanie , Sun Xuan , Heazlewood Chad K. , Li Songhui , Williams Brenda , Fulton Madeline , White Jacinta F. , Nebl Tom , Nefzger Christian M. , Polo Jose M. , Kile Benjamin T. , Kraus Felix , Ryan Michael T. , Sun Yu B. , Choong Peter F. M. , Ellis Sarah L. , Anko Minna-Liisa , Nilsson Susan K. 
Published: April 2023

AbstractMegakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic megakaryocytes (LCM) are critical negative regulators of HSC and critical for platelet formation. Using a mouse knockout model (Pf4-Srsf3Δ/Δ) with normal MK numbers, but essentially devoid of LCM, we demonstrate a pronounced increase in BM HSC concurrent with endogenous mobilization and extramedullary hematopoiesis. Severe thrombocytopenia is observed in animals with diminished LCM, although there is no change in MK ploidy distribution, uncoupling endoreduplication and platelet production. When HSC isolated from a microenvironment essentially devoid of LCM reconstitute hematopoiesis in lethally irradiated mice, the absence of LCM increases HSC in BM, blood and spleen, and the recapitulation of thrombocytopenia. In contrast, following a competitive transplant using minimal numbers of WT HSC together with HSC from a microenvironment with diminished LCM, sufficient WT HSC-generated LCM regulates a normal HSC pool and prevents thrombocytopenia. Importantly, LCM are conserved in humans.
Motor cortex gates distractor stimulus encoding in sensory cortex
Authors: Zhang Zhaoran , Zagha Edward 
Published: April 2023

AbstractSuppressing responses to distractor stimuli is a fundamental cognitive function, essential for performing goal-directed tasks. A common framework for the neuronal implementation of distractor suppression is the attenuation of distractor stimuli from early sensory to higher-order processing. However, details of the localization and mechanisms of attenuation are poorly understood. We trained mice to selectively respond to target stimuli in one whisker field and ignore distractor stimuli in the opposite whisker field. During expert task performance, optogenetic inhibition of whisker motor cortex increased the overall tendency to respond and the detection of distractor whisker stimuli. Within sensory cortex, optogenetic inhibition of whisker motor cortex enhanced the propagation of distractor stimuli into target-preferring neurons. Single unit analyses revealed that whisker motor cortex (wMC) decorrelates target and distractor stimulus encoding in target-preferring primary somatosensory cortex (S1) neurons, which likely improves selective target stimulus detection by downstream readers. Moreover, we observed proactive top-down modulation from wMC to S1, through the differential activation of putative excitatory and inhibitory neurons before stimulus onset. Overall, our studies support a contribution of motor cortex to sensory selection, in suppressing behavioral responses to distractor stimuli by gating distractor stimulus propagation within sensory cortex.