bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stronger coupling of emotional instability with reward processing in borderline personality disorder is predicted by schema modes
Authors: Csukly Gábor , Farkas Kinga , Fodor Tímea , Unoka Zsolt , Polner Bertalan 
Published: February 2023

AbstractBackgroundMood instability and risk-taking are hallmarks of borderline personality disorder (BPD). Schema modes are combinations of self-reflective evaluations, negative emotional states, and destructive coping strategies common in BPD. When activated, they can push patients with BPD into emotional turmoil and a dissociative state of mind. Our knowledge of the underlying neurocognitive mechanisms driving these changes is incomplete. We hypothesized that in patients with BPD, affective instability is more influenced by reward expectation, outcomes, and reward prediction errors (RPEs) during risky decision-making than in healthy controls. Additionally, we expected that these alterations would be related to schema modes.MethodsThirty-two patients with BPD and thirty-one healthy controls were recruited. We used an established behavioral paradigm to measure mood fluctuations during risky decision-making. The impact of expectations and RPEs on momentary mood was quantified by a computational model, and its parameters were estimated with hierarchical Bayesian analysis. Model parameters were compared using High-Density Intervals.ResultsWe found that model parameters capturing the influence of RPE and Certain Rewards on mood were significantly higher in patients with BPD than in controls. These model parameters correlated significantly with schema modes, but not with depression severity.ConclusionsBPD is coupled with altered associations between mood fluctuation and reward processing under uncertainty. Our findings seem to be BPD-specific, as they stand in contrast with the correlates of depressive symptoms. Future studies should establish the clinical utility of these alterations, such as predicting or assessing therapeutic response in BPD.
No Longer ‘Waiting for the Great Leap Forwards’? Advances in Local State-Voluntary and Community Sector Relationships During Covid-19
Authors: Cook Joanne , Thiery Harriet , Burchell Jon 
Published: February 2023

AbstractDespite the significant influence of localism on policy discourses in the UK in recent decades, there has been limited evidence of any fundamental changes in state-civil society relationships. The outbreak of the Covid-19 pandemic in 2020 created a new context for cross-sectoral collaboration, as the local Voluntary and Community Sector (VCS) and local communities moved to the forefront of the crisis response. This paper draws upon 49 semi-structured interviews with local authorities (LAs) and VCS organisations across England, Scotland and Wales, to explore how the pandemic has reshaped LA-VCS collaboration. Examining the evolution of a range of local collaborative frameworks during the Covid-19 crisis, the article examines what enabled these collaborations to develop, how they operated and what insights can be derived regarding both the conditions for collaboration to flourish and the capacity to sustain this going forward. The findings offer insights into what more progressive forms of collaboration might look like during the transition from crisis and into recovery. It contributes to broader debates about whether the models deployed during Covid-19 represent a pathway to more consensus-based collaboration after a decade of antagonism between civil society and the state.
Efficacy of technology-based personalised feedback on diet quality in young Australian adults: results for the advice, ideas and motivation for my eating (Aim4Me) randomised controlled trial
Authors: Haslam Rebecca L , Baldwin Jennifer N , Pezdirc Kristine , Truby Helen , Attia John , Hutchesson Melinda J , Burrows Tracy , Callister Robin , Hides Leanne , Bonevski Billie , Kerr Deborah A , Kirkpatrick Sharon I , Rollo Megan E , McCaffrey Tracy A , Collins Clare E 
Published: February 2023

AbstractObjective:Web-based dietary interventions could support healthy eating. The Advice, Ideas and Motivation for My Eating (Aim4Me) trial investigated the impact of three levels of personalised web-based dietary feedback on diet quality in young adults. Secondary aims were to investigate participant retention, engagement and satisfaction.Design:Randomised controlled trial.Setting:Web-based intervention for young adults living in Australia.Participants:18–24-year-olds recruited across Australia were randomised to Group 1 (control: brief diet quality feedback), Group 2 (comprehensive feedback on nutritional adequacy + website nutrition resources) or Group 3 (30-min dietitian consultation + Group 2 elements). Australian Recommended Food Score (ARFS) was the primary outcome. The ARFS subscales and percentage energy from nutrient-rich foods (secondary outcomes) were analysed at 3, 6 and 12 months using generalised linear mixed models. Engagement was measured with usage statistics and satisfaction with a process evaluation questionnaire.Results:Participants (n 1005, 85 % female, mean age 21·7 ± 2·0 years) were randomised to Group 1 (n 343), Group 2 (n 325) and Group 3 (n 337). Overall, 32 (3 %), 88 (9 %) and 141 (14 %) participants were retained at 3, 6 and 12 months, respectively. Only fifty-two participants (15 % of Group 3) completed the dietitian consultation. No significant group-by-time interactions were observed (P > 0·05). The proportion of participants who visited the thirteen website pages ranged from 0·6 % to 75 %. Half (Group 2 = 53 %, Group 3 = 52 %) of participants who completed the process evaluation (Group 2, n 111; Group 3, n 90) were satisfied with the programme.Conclusion:Recruiting and retaining young adults in web-based dietary interventions are challenging. Future research should consider ways to optimise these interventions, including co-design methods.
Mapping 21st Century Global Coastal Land Reclamation
Authors: Sengupta Dhritiraj , Choi Young Rae , Tian Bo , Brown Sally , Meadows Michael , Hackney Christopher R. , Banerjee Abhishek , Li Yingjie , Chen Ruishan , Zhou Yunxuan 
Published: February 2023

AbstractIncreasing population size and economic dependence on the coastal zone, coupled with the growing need for residential, agricultural, industrial, commercial and green space infrastructure, are key drivers of land reclamation. Until now, there has been no comprehensive assessment of the global distribution of land use on reclaimed space at the coast. Here, we analyze Landsat satellite imagery from 2000 to 2020 to quantify the spatial extent, scale, and land use of urban coastal reclamation for 135 cities with populations in excess of 1 million. Findings indicate that 78% (106/135) of these major coastal cities have resorted to reclamation as a source of new ground, contributing a total 253,000 ha of additional land to the Earth's surface in the 21st century, equivalent to an area the size of Luxembourg. Reclamation is especially prominent in East Asia, the Middle East, and Southeast Asia, followed by Western Europe and West Africa. The most common land uses on reclaimed spaces are port extension (>70 cities), followed by residential/commercial (30 cities) and industrial (19 cities). While increased global trade and the rapid urbanization have driven these uses, we argue that a city's prestigious place‐making effort to gain global reputation is emerging as another major driver underlying recent reclamation projects to create tourist and green spaces Meanwhile, the study suggests that 70% of recent reclamation has occurred in areas identified as potentially exposed to extreme sea level rise (SLR) by 2100 and this presents a significant challenge to sustainable development at the coast.
The Effect of Energetic Ion Dispersionless Injections on the Ring Current Dynamics
Authors: Zhuang Yan , Yue Chao , Zong Qiu‐Gang , Zhou Xu‐Zhi , Fu Haobo , Mitchell Donald G. , Gkioulidou M. , Cooper Matthew 
Published: February 2023

AbstractEnergetic particle injections, usually observed as sudden flux enhancements of charged particles from tens to hundreds of keV, are one of the main mechanisms for ring current enhancement. In this study, we statistically analyzed the influence of dispersionless injections on Earth's ring current based on the measurements of radiation belt storm probes ion composition experiment onboard Van Allen Probes from 2013 to 2019. We identified 813 dispersionless proton injection events, which are mainly in the pre‐midnight sector. With a greater SuperMAG electrojet index (SME), the observed injections extend to lower L shells. Meanwhile, Helium (He+) and oxygen (O+) ions experience almost simultaneous injections with protons. Superposed epoch results show that ion energy densities enhance significantly after injections. As SMEmax increases, the ring current energy densities of all three species are increasing, and the magnitude of the enhancements, defined as the ratio of the energy densities after and before the injection, hardly changes for protons (∼2.0) and He+ ions (∼2.0) but increases for O+ ions (2.6 and 3.0 for SMEmax < 1,000 nT and SMEmax ≥ 1,000 nT, respectively), suggesting the contribution of O+ ions to ring current becomes more significant during super substorms. With proton injections, the dawn‐dusk electric field is enhanced sharply to twice as large as before. Simultaneously, there is a dip followed by gradual dipolarization of the magnetic fields. Moreover, particle anisotropies increase following ion injections, which may generate electromagnetic ion cyclotron waves. These statistical results indicate that ion injections during substorms contribute significantly to the ring current.
Upscaling Permeability Using Multiscale X‐Ray‐CT Images With Digital Rock Modeling and Deep Learning Techniques
Authors: Jiang Fei , Guo Yaotian , Tsuji Takeshi , Kato Yoshitake , Shimokawara Mai , Esteban Lionel , Seyyedi Mojtaba , Pervukhina Marina , Lebedev Maxim , Kitamura Ryuta 
Published: February 2023

AbstractThis study presents a workflow to predict the upscaled absolute permeability of the rock core direct from CT images whose resolution is not sufficient to allow direct pore‐scale permeability computation. This workflow exploits the deep learning technique with the data of raw CT images of rocks and their corresponding permeability value obtained by performing flow simulation on high‐resolution CT images. The permeability map of a much larger region in the rock core is predicted by the trained neural network. Finally, the upscaled permeability of the entire rock core is calculated by the Darcy flow solver, and the results showed a good agreement with the experiment data. This proposed deep learning based upscaling method allows estimating the permeability of large‐scale core samples while preserving the effects of fine‐scale pore structure variations due to the local heterogeneity.
CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome
Authors: Sugawara Yuka , Kato Hideki , Nagasaki Masao , Yoshida Yoko , Fujisawa Madoka , Minegishi Naoko , Yamamoto Masayuki , Nangaku Masaomi 
Published: February 2023

AbstractAtypical hemolytic uremic syndrome (aHUS) is a rare complement-mediated disease that manifests as the triad of thrombotic microangiopathy. We identified two aHUS patients with neither anti-complement factor H (CFH) antibodies nor causative variants of seven aHUS-related genes (CFH, CFI, CFB, C3, MCP, THBD, and DGKE); however, their plasma showed increased levels of hemolysis by hemolytic assay, which strongly suggests CFH-related abnormalities. Using a copy number variation (CNV) analysis of the CFH/CFHR gene cluster, we identified CFH-CFHR1 hybrid genes in these patients. We verified the absence of aHUS-related abnormal CNVs of the CFH gene in control genomes of 2036 individuals in the general population, which suggests that pathogenicity is related to these hybrid genes. Our study emphasizes that, for patients suspected of having aHUS, it is important to perform an integrated analysis based on a clinical examination, functional analysis, and detailed genetic investigation.
Clinical and economic burden associated with graft-versus-host disease following allogeneic hematopoietic cell transplantation in France
Authors: Michonneau David , Quignot Nadia , Jiang Heng , Reichenbach Dawn , Kelly Maebh , Burrell Anita , Zhang Xiang , Thiruvillakkat Kris , Mohty Mohamad 
Published: February 2023

AbstractThe real-world clinical and economic burden of graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation has not been comprehensively studied in France. Clinical outcomes, healthcare resource utilization and costs associated with acute GVHD (aGVHD), chronic GVHD (cGVHD), acute plus chronic GVHD (a+cGVHD) versus no GVHD were compared using French administrative claims data. After propensity score matching, 1934, 408, and 1268 matched pairs were retained for the aGVHD, cGVHD, and a+cGVHD cohorts, respectively. Compared with patients with no GVHD, odds of developing severe infection were greater in patients with aGVHD (odds ratio: 1.7 [95% confidence interval: 1.4, 2.1]). Compared with patients with no GVHD, mortality rates were higher in patients with aGVHD (rate ratio (RR): 1.6 [1.4, 1.7]) and with a+cGVHD (RR: 1.1 [1.0, 1.2]) but similar in patients with cGVHD (RR: 0.9 [0.7, 1.1]). Mean overnight hospital admission rates per patient-year were significantly higher in patients with aGVHD and a+cGVHD compared with no GVHD. Total direct costs (range €174,482–332,557) were 1.2, 1.5, and 1.9 times higher for patients with aGVHD, cGVHD, and a+cGVHD, respectively, versus patients with no GVHD. These results highlight the significant unmet need for effective treatments of patients who experience GVHD.
Head and neck cancer patient-derived tumouroid cultures: opportunities and challenges
Authors: Basnayake B. W. M. Thilini J. , Leo Paul , Rao Sudha , Vasani Sarju , Kenny Lizbeth , Haass Nikolas K. , Punyadeera Chamindie 
Published: February 2023

AbstractHead and neck cancers (HNC) are the seventh most prevalent cancer type globally. Despite their common categorisation, HNCs are a heterogeneous group of malignancies arising in various anatomical sites within the head and neck region. These cancers exhibit different clinical and biological manifestations, and this heterogeneity also contributes to the high rates of treatment failure and mortality. To evaluate patients who will respond to a particular treatment, there is a need to develop in vitro model systems that replicate in vivo tumour status. Among the methods developed, patient-derived cancer organoids, also known as tumouroids, recapitulate in vivo tumour characteristics including tumour architecture. Tumouroids have been used for general disease modelling and genetic instability studies in pan-cancer research. However, a limited number of studies have thus far been conducted using tumouroid-based drug screening. Studies have concluded that tumouroids can play an essential role in bringing precision medicine for highly heterogenous cancer types such as HNC.
Pyroptosis and degenerative diseases of the elderly
Authors: Zhou Jiamin , Qiu Jingjing , Song Yuwan , Liang Tiantian , Liu Sha , Ren Chao , Song Xicheng , Cui Limei , Sun Yan 
Published: February 2023

AbstractPyroptosis is a recently described mechanism of programmed cell death mediated by proteins of the gasdermin family. Widely recognized signaling cascades include the classical, non-classical, caspase-3-dependent gasdermin E and caspase-8-dependent gasdermin D pathways. Additional pyroptotic pathways have been subsequently reported. With the rising prevalence of advanced age, the role of pyroptosis in the degenerative diseases of the elderly has attracted increased research attention. This article reviews the primary mechanisms of pyroptosis and summarizes progress in the research of degenerative diseases of the elderly such as presbycusis, age-related macular degeneration, Alzheimer’s disease, intervertebral disc degeneration, and osteoarthritis.
Direct synthesis of sila-benzoazoles through hydrosilylation and rearrangement cascade reaction of benzoazoles and silanes
Authors: Liu Tianwei , Yang Mo , He Jianghua , Li Shuhua , Zhang Yuetao 
Published: February 2023

AbstractSila-isosteres have attracted increasing attention due to their potential application in a variety of fields and their different properties compared to their carbon-containing analogs. However, the preparation of these silicon-containing compound remains challenging and thus the development of alternative synthetic methodologies is desirable. Here, we employ B(C6F5)3 as catalyst to enable the synthesis of highly functionalized sila-benzoazoles via hydrosilylation and rearrangement cascade reaction of benzoazoles and commercially available silanes. This strategy also exhibits remarkable features such as 100% atom-economy, good functional group tolerance, broad substrate scope, easy scale-up and good catalytic performance, demonstrating its potential application in sila-isostere synthesis.
Hadronic uncertainties versus new physics for the W boson mass and Muon g − 2 anomalies
Authors: Athron Peter , Fowlie Andrew , Lu Chih-Ting , Wu Lei , Wu Yongcheng , Zhu Bin 
Published: February 2023

AbstractThere are now two single measurements of precision observables that have major anomalies in the Standard Model: the recent CDF measurement of the W mass shows a 7σ deviation and the Muon g − 2 experiment at FNAL confirmed a long-standing anomaly, implying a 4.2σ deviation. Doubts regarding new physics interpretations of these anomalies could stem from uncertainties in the common hadronic contributions. We demonstrate that these two anomalies pull the hadronic contributions in opposite directions by performing electroweak fits in which the hadronic contribution was allowed to float. The fits show that including the g − 2 measurement worsens the tension with the CDF measurement and conversely that adjustments that alleviate the CDF tension worsen the g − 2 tension beyond 5σ. This means that if we adopt the CDF W mass measurement, the case for new physics in either the W mass or muon g − 2 is inescapable regardless of the size of the SM hadronic contributions. Lastly, we demonstrate that a mixed scalar leptoquark extension of the Standard Model could explain both anomalies simultaneously.
TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity
Authors: Kang Sujin , Kim Jaekyung , Park Areum , Koh Minsoo , Shin Wonji , Park Gayoung , Lee Taeyun A. , Kim Hyung Jin , Han Heonjong , Kim Yongbo , Choi Myung Kyung , Park Jae Hyung , Lee Eunhye , Cho Hyun-Soo , Park Hyun Woo , Cheon Jae Hee , Lee Sungwook , Park Boyoun 
Published: February 2023

AbstractThe cortical actin cytoskeleton plays a critical role in maintaining intestinal epithelial integrity, and the loss of this architecture leads to chronic inflammation, as seen in inflammatory bowel disease (IBD). However, the exact mechanisms underlying aberrant actin remodeling in pathological states remain largely unknown. Here, we show that a subset of patients with IBD exhibits substantially higher levels of tripartite motif-containing protein 40 (TRIM40), a gene that is hardly detectable in healthy individuals. TRIM40 is an E3 ligase that directly targets Rho-associated coiled-coil-containing protein kinase 1 (ROCK1), an essential kinase involved in promoting cell-cell junctions, markedly decreasing the phosphorylation of key signaling factors critical for cortical actin formation and stabilization. This causes failure of the epithelial barrier function, thereby promoting a long-lived inflammatory response. A mutant TRIM40 lacking the RING, B-box, or C-terminal domains has impaired ability to accelerate ROCK1 degradation-driven cortical actin disruption. Accordingly, Trim40-deficient male mice are highly resistant to dextran sulfate sodium (DSS)-induced colitis. Our findings highlight that aberrant upregulation of TRIM40, which is epigenetically silenced under healthy conditions, drives IBD by subverting cortical actin formation and exacerbating epithelial barrier dysfunction.
Genome-wide association study using whole-genome sequencing identifies risk loci for Parkinson’s disease in Chinese population
Authors: Pan Hongxu , Liu Zhenhua , Ma Jinghong , Li Yuanyuan , Zhao Yuwen , Zhou Xiaoxia , Xiang Yaqin , Wang Yige , Zhou Xun , He Runcheng , Xie Yali , Zhou Qiao , Yuan Kai , Xu Qian , Sun Qiying , Wang Junling , Yan Xinxiang , Zhang Hainan , Wang Chunyu , Lei Lifang , Liu Weiguo , Wang Xuejing , Ding Xuebing , Wang Tao , Xue Zheng , Zhang Zhentao , Chen Ling , Wang Qing , Liu Yonghong , Tang Jiayu , Zhang Xuewei , Peng Shifang , Wang Chaodong , Ding Jianqing , Liu Chunfeng , Wang Lijuan , Chen Haibo , Shen Lu , Jiang Hong , Wu Xinyin , Tan Hongzhuan , Luo Dan , Xiao Shuiyuan , Chen Xiang , Tan Jieqiong , Hu Zhengmao , Chen Chao , Xia Kun , Zhang Zhuohua , Foo Jia Nee , Blauwendraat Cornelis , Nalls Mike A. , Singleton Andrew B. , Liu Jun , Chan Piu , Zheng Houfeng , Li Jinchen , Guo Jifeng , Yang Jian , Tang Beisha ,   the Parkinson’s Disease & Movement Disorders Multicenter Database and Collaborative Network in China (PD-MDCNC), Liu Zhenhua , Jiang Hong , Chan Piu , Li Jinchen , Guo Jifeng , Tang Beisha 
Published: February 2023

AbstractGenome-wide association studies (GWASs) have identified numerous susceptibility loci for Parkinson’s disease (PD), but its genetic architecture remains underexplored in populations of non-European ancestry. To identify genetic variants associated with PD in the Chinese population, we performed a GWAS using whole-genome sequencing (WGS) in 1,972 cases and 2,478 controls, and a replication study in a total of 8209 cases and 9454 controls. We identified one new risk variant rs61204179 (Pcombined = 1.47 × 10−9) with low allele frequency, four previously reported risk variants (NUCKS1/RAB29-rs11557080,SNCA-rs356182,FYN-rs997368, andVPS13C-rs2251086), as well as three risk variants inLRRK2coding region (A419V, R1628P, and G2385R) with genome-wide significance (P < 5 × 10−8) for PD in Chinese population. Moreover, of the reported genome-wide significant risk variants found mostly in European ancestry populations, the correlation coefficient (rb) of effect size accounting for sampling errors was 0.91 between datasets and 63.6% attainedP < 0.05 in Chinese population. Accordingly, we estimated a heritability of 0.14–0.18 for PD, and a moderate genetic correlation between European ancestry and Chinese populations (rg = 0.47, se = 0.21). Polygenic risk score (PRS) analysis revealed that individuals with PRS values in the highest quartile had a 3.9-fold higher risk of developing PD than the lowest quartile. In conclusion, the present GWAS identified PD-associated variants in Chinese population, as well as genetic factors shared among distant populations. Our findings shed light on the genetic homogeneity and heterogeneity of PD in different ethnic groups and suggested WGS might continue to improve our understanding of the genetic architecture of PD.