bluuebunny/crossref_metadata_2025_split huggingface dataset:
Required biological time for lung maturation and duration of invasive ventilation: a Korean cohort study of very low birth weight infants
Authors: Jo Heui Seung , Lim Myoung Nam , Cho Sung-Il 
Published: June 2023

BackgroundWe investigated the duration of invasive ventilation among very low birth weight (VLBW) infants to evaluate the current minimum time required for lung maturation to breathe without ventilator assistance after preterm birth.MethodsA total of 14,658 VLBW infants born at ≤32+6 weeks between 2013 and 2020 were enrolled. Clinical data were collected from the Korean Neonatal Network, a national prospective cohort registry of VLBW infants from 70 neonatal intensive care units. Differences in the duration of invasive ventilation according to gestational age and birth weight were investigated. Recent trends and changes in assisted ventilation duration and associated perinatal factors between 2017–20 and 2013–16 were compared. Risk factors related to the duration of assisted ventilation were also identified.ResultsThe overall duration of invasive ventilation was 16.3 days and the estimated minimum time required corresponded to 30+4 weeks of gestation. The median duration of invasive ventilation was 28.0, 13.0, 3.0, and 1.0 days at &lt;26, 26–27, 28–29, and 30–32 weeks of gestation, respectively. In each gestational age group, the estimated minimum weaning points from the assisted ventilator were 29+5, 30+2, 30+2, and 31+5 weeks of gestation. The duration of non-invasive ventilation (17.9 vs. 22.5 days) and the incidence of bronchopulmonary dysplasia (28.1% vs. 31.9%) increased in 2017–20 (n = 7,221) than in 2013–16 (n = 7,437). In contrast, the duration of invasive ventilation and overall survival rate did not change during the periods 2017–20 and 2013–16. Surfactant treatment and air leaks were associated with increased duration of invasive ventilation (inverse hazard ratio 1.50, 95% CI, 1.04–2.15; inverse hazard ratio 1.62, 95% CI, 1.29–2.04). We expressed the incidence proportion of ventilator weaning according to the invasive ventilation duration using Kaplan–Meier survival curves. The slope of the curve slowly decreased as gestational age and birth weight were low and risk factors were present.ConclusionsThis population-based data on invasive ventilation duration among VLBW infants suggest the present limitation of postnatal lung maturation under specific perinatal conditions after preterm birth. Furthermore, this study provides detailed references for designing and/or assessing earlier ventilator weaning protocols and lung protection strategies by comparing populations or neonatal networks.
Efficacy analysis of enhanced recovery after surgery in laparoscopic-assisted radical resection of type I choledochal cyst
Authors: Zhang Bing , Fang Yifan , Wu Dianming , Xie Siqi , Fang Xuejuan 
Published: June 2023

ObjectiveThe objective of this study was to investigate the feasibility and effectiveness of laparoscopic-assisted radical resection of type I choledochal cyst (CC) guided by the principles of enhanced recovery after surgery (ERAS).MethodsA retrospective cohort study of type I CC admitted to our hospital between May 2020 and December 2021 were analyzed, a total of 41 patients with choledochal cyst underwent surgery during this period and 30 cases were selected based on inclusion and exclusion criteria. Patients (n = 15) who received the traditional treatment from May 2020 to March 2021 were included in the traditional group. Patients (n = 15) who received ERAS from April 2021 to December 2021 were included in the ERAS group. Both groups underwent surgery performed by the same surgical team. Preoperative data of the two groups were recorded, and relevant data were statistically analyzed and compared.ResultsThere was a statistically significant difference in the dose of opioids. Significant differences were observed between the ERAS and traditional groups in the results of the FLACC pain assessment scale on the 1st and 2nd day after surgery, time of gastric tube, urinary catheter and abdominal drainage tube removal, time of first defecation after operation, time of first eating after operation, time to reach full food intake, results of CRP, ALB, and ALT on the 3rd and 7th postoperative day, postoperative hospital stay, and total treatment cost. No significant differences were observed between the two groups in terms of gender, age, body weight, cyst size, preoperative CRP, ALB, ALT, intraoperative blood loss, operation time, and the number of cases converted to laparotomy. Neither the FLACC pain assessment scale on the 3rd day after surgery, the incidence of postoperative complications, nor the rate of readmission within 30 days showed significant differences.ConclusionsLaparoscopic-assisted radical resection of type I CC guided by the principles of ERAS is safe and effective for children. The ERAS concept demonstrated advantages over traditional laparoscopic surgery, including reduced opioid use, shorter time to first postoperative defecation, earlier resumption of postoperative feeding, shorter time to reach full feeding, shorter postoperative hospital stay, and lower total treatment cost.
Morphosyntactic development in German-speaking individuals with Down syndrome—longitudinal data
Authors: Witecy Bernadette , Wimmer Eva , Neitzel Isabel , Penke Martina 
Published: June 2023

IntroductionThe present study provides longitudinal data on the development of receptive and expressive grammar in children and adolescents with Down syndrome and addresses the role of nonverbal cognitive abilities and verbal short-term memory for morphosyntactic development.MethodSeventeen German-speaking individuals with Down syndrome (aged 4;6–17;1 years at first testing (T1)) were assessed twice, 4;4–6;6 years apart. For a subset of five participants, there was also a third assessment 2 years after the second. Receptive grammar, nonverbal cognition, and verbal short-term memory were tested using standardized measures. For expressive grammar, elicitation tasks were used to assess the production of subject-verb agreement and ofwh-questions.ResultsAt group level, the participants showed a significant increase in grammar comprehension from T1 to T2. However, progress diminished with increasing chronological age. Notable growth could not be observed beyond the age of 10 years.With respect to expressive grammatical abilities, progress was limited to those participants who had mastered verbal agreement inflection around age 10 years. Individuals who did not master verbal agreement by late childhood achieved no progress in producingwh-questions, either.There was an increase in nonverbal cognitive abilities in the majority of participants. Results for verbal short-term memory followed a similar pattern as those for grammar comprehension. Finally, neither nonverbal cognition nor verbal short-term memory were related to changes in receptive or expressive grammar.DiscussionThe results point to a slowdown in the acquisition of receptive grammar which starts before the teenage years. For expressive grammar, improvement inwh-question production only occurred in individuals with good performance in subject-verb agreement marking, which suggests that the latter might have a trigger function for further grammatical development in German-speaking individuals with Down syndrome. The study provides no indication that nonverbal cognitive abilities or verbal short-term memory performance determined the receptive or expressive development. The results lead to clinical implications for language therapy.
Psychiatric symptoms in Long-COVID patients: a systematic review
Authors: Marchi Mattia , Grenzi Pietro , Serafini Valentina , Capoccia Francesco , Rossi Federico , Marrino Patrizia , Pingani Luca , Galeazzi Gian Maria , Ferrari Silvia 
Published: June 2023

ObjectivePeople who have been infected by COVID-19 showing persistent symptoms after 4 weeks from recovery are thought to suffer from Long-COVID syndrome (LC). There is uncertainty on the clinical manifestations of LC. We undertook a systematic review to summarize the available evidence about the main psychiatric manifestations of LC.MethodPubMed (Medline), Scopus, CINHAL, PsycINFO, and EMBASE were searched until May 2022. Studies reporting estimation of emerging psychiatric symptoms and/or psychiatric diagnoses among adult people with LC were included. Pooled prevalence for each psychiatric condition was calculated in absence of control groups to compare with.ResultsThirty-three reports were included in the final selection, corresponding to 282,711 participants with LC. After 4 weeks from COVID-19 infection recovery, participants reported the following psychiatric symptoms: depression, anxiety, post-traumatic symptoms (PTS), cognitive and sleeping disturbances (i.e., insomnia or hypersomnia). The most common psychiatric manifestation resulted to be sleep disturbances, followed by depression, PTS, anxiety, and cognitive impairment (i.e., attention and memory deficits). However, some estimates were affected by important outlier effect played by one study. If study weight was not considered, the most reported condition was anxiety.ConclusionsLC may have non-specific psychiatric manifestations. More research is needed to better define LC and to differentiate it from other post-infectious or post-hospitalization syndromes.Systematic review registrationPROSPERO (CRD42022299408).
Night-time population consistently explains the transmission dynamics of coronavirus disease 2019 in three megacities in Japan
Authors: Okada Yuta , Yamasaki Syudo , Nishida Atsushi , Shibasaki Ryosuke , Nishiura Hiroshi 
Published: June 2023

BackgroundMobility data are crucial for understanding the dynamics of coronavirus disease 2019 (COVID-19), but the consistency of the usefulness of these data over time has been questioned. The present study aimed to reveal the relationship between the transmissibility of COVID-19 in Tokyo, Osaka, and Aichi prefectures and the daily night-time population in metropolitan areas belonging to each prefecture.MethodsIn Japan, the de facto population estimated from GPS-based location data from mobile phone users is regularly monitored by Ministry of Health, Labor, and Welfare and other health departments. Combined with this data, we conducted a time series linear regression analysis to explore the relationship between daily reported case counts of COVID-19 in Tokyo, Osaka, and Aichi, and night-time de facto population in downtown areas estimated from mobile phone location data, from February 2020 to May 2022. As an approximation of the effective reproduction number, the weekly ratio of cases was used. Models using night-time population with lags ranging from 7 to 14 days were tested. In time-varying regression analysis, the night-time population level and the daily change in night-time population level were included as explanatory variables. In the fixed-effect regression analysis, the inclusion of either the night-time population level or daily change, or both, as explanatory variables was tested, and autocorrelation was adjusted by introducing first-order autoregressive error of residuals. In both regression analyses, the lag of night-time population used in best fit models was determined using the information criterion.ResultsIn the time-varying regression analysis, night-time population level tended to show positive to neutral effects on COVID-19 transmission, whereas the daily change of night-time population showed neutral to negative effects. The fixed-effect regression analysis revealed that for Tokyo and Osaka, regression models with 8-day-lagged night-time population level and daily change were the best fit, whereas in Aichi, the model using only the 9-day-lagged night-time population level was the best fit using the widely applicable information criterion. For all regions, the best-fit model suggested a positive relationship between night-time population and transmissibility, which was maintained over time.ConclusionOur results revealed that, regardless of the period of interest, a positive relationship between night-time population levels and COVID-19 dynamics was observed. The introduction of vaccinations and major outbreaks of Omicron BA. Two subvariants in Japan did not dramatically change the relationship between night-time population and COVID-19 dynamics in three megacities in Japan. Monitoring the night-time population continues to be crucial for understanding and forecasting the short-term future of COVID-19 incidence.
Healthy Bus Drivers, Sustainable Public Transport: A Three-Time Repeated Cross-Sectional Study in Switzerland
Authors: Remy Viviane Fiona Mathilde , Guseva Canu Irina 
Published: June 2023

Objectives:To study the change in the prevalence of bus drivers’ health outcomes between 2010 and 2022 and their relationship with working conditions.Method:Unionized bus drivers completed a self-administered questionnaire in 2010, 2018, and 2022 on 13 health outcomes, sick leaves, and accidents and working conditions and their change during SARS-CoV-2 crisis. For outcomes which prevalence increased since 2010, we performed logistic regression models adjusted for covariates.Results:The study sample included 772 participants in 2010, 393 in 2018, and 916 in 2022. The most prevalent health problem (≥50%) was shoulder or neck muscle pain. The most tedious working conditions were working days over 10 h. Shoulder or neck pain, sleep disorders, sick leaves, and accidents increased since 2010 and were associated with working conditions, and co-morbidity. The SARS-CoV-2 pandemic had additional negative consequences.Conclusion:Most bus drivers’ working and health conditions worsened in the last 12 years. Given the study design, the results deserve a cautious interpretation and generalization. Cohort studies should confirm these results and inform interventions targeting the most tedious and harmful working conditions.
Charge Transfer and Charge Trapping Processes in Ca- or Al-Co-doped Lu2SiO5 and Lu2Si2O7 Scintillators Activated by Pr3+ or Ce3+ Ions
Authors: Laguta Valentyn , Havlak Lubomir , Babin Vladimir , Barta Jan , Pejchal Jan , Nikl Martin 
Published: June 2023

Lutetium oxyorthosilicate Lu2SiO5 (LSO) and pyrosilicate Lu2Si2O7 (LPS) activated by Ce3+ or Pr3+ are known to be effective and fast scintillation materials for the detection of X-rays and γ-rays. Their performances can be further improved by co-doping with aliovalent ions. Herein, we investigate the Ce3+(Pr3+) → Ce4+(Pr4+) conversion and the formation of lattice defects stimulated by co-doping with Ca2+ and Al3+ in LSO and LPS powders prepared by the solid-state reaction process. The materials were studied by electron paramagnetic resonance (EPR), radioluminescence spectroscopy, and thermally stimulated luminescence (TSL), and scintillation decays were measured. EPR measurements of both LSO:Ce and LPS:Ce showed effective Ce3+ → Ce4+ conversions stimulated by Ca2+ co-doping, while the effect of Al3+ co-doping was less effective. In Pr-doped LSO and LPS, a similar Pr3+ → Pr4+ conversion was not detected by EPR, suggesting that the charge compensation of Al3+ and Ca2+ ions is realized via other impurities and/or lattice defects. X-ray irradiation of LPS creates hole centers attributed to a hole trapped in an oxygen ion in the neighborhood of Al3+ and Ca2+. These hole centers contribute to an intense TSL glow peak at 450–470 K. In contrast to LPS, only weak TSL peaks are detected in LSO and no hole centers are visible via EPR. The scintillation decay curves of both LSO and LPS show a bi-exponential decay with fast and slow component decay times of 10–13 ns and 30–36 ns, respectively. The decay time of the fast component shows a small (6–8%) decrease due to co-doping.
Differential effects of a 12-week aerobic exercise program on health-related physical fitness, physiological and biochemical markers among obese adults: a randomized controlled trial.
Authors: Govindasamy Karuppasamy , Suresh Chandrababu , Kaur Dilpreet , Pramanik Mou , Anitha John Bosco 
Published: June 2023

Background: work out is an valuable approach for improving standard of living physiological, biochemical, and physical strength in obese patients; though, few researches have mainly focal point on early survival rates, minorities, in physically passive men, and overweight men, or examined individual & combined workout plan and measured body composition markers.
Objective: In this research we have describes the effect of a 12-week different aerobic exercise involvement on obese people's self-reported result, physical strength, physiological and biochemical markers in ethnically mixed, physically motionless, obese adults.
Methods: Total (n = 60) male adults with obese (Mean ± SD; age: 18.92 ± 1.54 yrs.; height: 172.4 ± 5.4 cm.; weight: 84.4 ± 6.3 kg) were randomly allocated into three equal (n = 20) groups: Step Aerobic Exercise Training (SAET), Floor Aerobic Exercise Training (FAET) or a control group. The SAET & FAET training protocol has been performed three days of a week during period of study (12 weeks). All the selected variables of physical fitness, physiological and biochemical markers have been examined at baseline and 12 weeks. Group under control have been found not performing workout.
Results: The exercise program SAET & FAET significantly improved in muscular strength, cardiovascular endurance, flexibility, muscular endurance, vital capacity, and breath holding time (p < 0.05). The workout schedule reduced significantly % body fat, mean resting pulse rate, respiratory rate and arterial blood pressure, (p < 0.05). Furthermore, the lipids levels of total triglycerides, cholesterol, and low density lipoprotein have been reduced significantly in SAET & FAET, high density lipoprotein enhance significantly (p < 0.05).
Conclusion: Research’s finding advocate that 12-weeks regular SAET & FAET protocols have greater effects than control group on physical fitness of health related, physiological and biochemical variables in obese male adult individuals.
Information and Analytical System "Republican Epidemiological Registry of Patients with Hematological Diseases"
Authors: Искров И.А. , Усс А.Л. , Талако Т.М. , Красько О.В. 
Published: June 2023

В Республике Беларусь первые эпидемиологические (неинфекционные) регистры появились после аварии на Чернобыльской атомной станции, когда мониторинг здоровья населения стал проводиться повсеместно с целью наиболее раннего выявления особенностей динамики заболеваемости. До 1988 г. в Республике Беларусь не было регистра болезней крови. Белорусский республиканский регистр болезней крови начал создаваться в июле 1988 г. (письмо Министерства здравоохранения Республики Беларусь № 22-3/82дсп от 20.07.1988) в рамках выполнения союзной программы С-27. Регистр содержит персонифицированную информацию о каждом пациенте с гемобластозами начиная с 1979 г. Однако на настоящее время используемая модель формирования базы данных регистра устарела и не отвечает современным требованиям в решении задач, направленных на совершенствование методов диагностики и лечения гематологических пациентов, и не позволяет учитывать материальные и экономические ресурсы, затрачиваемые на лечение каждого пациента. Разработка и внедрение информационно-аналитической системы «Республиканский эпидемиологический регистр пациентов с гематологическими заболеваниями» позволили автоматизировать процесс сбора, накопления, обработки и представления информации по каждому случаю гематологического заболевания, осуществлять планирование оказания специализированной гематологической помощи взрослому населению страны.
First epidemiological (non-infectious) registries appeared in the Republic of Belarus after the accident at the Chernobyl nuclear power plant, when public health monitoring began to be carried out everywhere to identify early characteristics of the incidence dynamics. The registry of blood diseases did not exist in the Republic of Belarus before 1988. The Belarusian republican registry of blood diseases began to be created in July 1988 (letter of the Ministry of Health of the Republic of Belarus No. 22-3/82dsp, July 20, 1988) as a result of the C-27 scientific program. The registry contains personalized information about each patient with hematological malignancies, starting from 1979. However, the currently used model of the registry database does not meet modern requirements for improving the methods of diagnosis and treatment of hematological patients, and does not allow analyzing material and economic resources spent on each patient. Development and implementation of the information and analytical system "Republican epidemiological registry of patients with hematological diseases" made possible automatized collection, accumulation, processing and presentation of information on each case of a hematological pathology, as well as planning of specialized hematological medical care to the adult population of the country.
Implementasi Payment Gateway dengan Menggunakan Midtrans pada Website UMKM Geberco
Authors: Fatman Yenni , Khoirun Nafisah Nadaa , Bendoro Jembar Pambudi Pugud 
Published: June 2023

Memfasilitasi sebuah platform untuk masyarakat dapat berbelanja secara online sangat dibutuhkan oleh penjual manapun begitu juga untuk perusahaan Geberco. Geberco merupakan wadah untuk penjual menjual baju sablonan dan kemeja dari berbagai model dan motif. Sebelumnya Geberco melakukan transaksi secara langsung dimana hal tersebut mengakibatkan membutuhkan waktu yang lama serta terdapat nya banyak permasalahan lain tentang pemesanan dan pembayaran. Oleh sebab itu dibutuhkan sebuah website yang dapat memudahkan interaksi antara pembeli dan penjual. Dalam proses peningkatan bisnis dan usaha kecil yang mempunyai sebuah website atau toko online bagi beberapa usaha kecil di Indonesia dibutuhkan fitur pembayaran yang aman dan mudah, maka dari itu dirancanglah pengimplementasian payment gateway dengan menggunakan midtrans yang memudahkan customer dalam melakukan pembayaran ketika membeli produk dari toko usaha tersebut. Metode yang digunakkan dalam pembuatan perangkat lunak adalah metode pengembangan perangkat lunak Agile, menggunakan aplikasi midtrans.com untuk implementasi payment gateway dan menggunakan kerangka kerja perangkat lunak Laravel. Midtrans telah dipakai lebih dari lima perusahaan besar seperti Tokopedia, Bukalapak, Cottonink, Garuuda Indonesia, dan Pegi-pegi. Dengan implementasi payment gateway terhadap perangkat lunak mudahkan customer dalam melakukan pembayaran pada setiap barang yang dibeli pada website. Penerapan payment gateway menggunakan midtrans dengan memakai pengembangan perangkat lunak agile menjadi memudahkan dalam proses implementasi.