bluuebunny/crossref_metadata_2025_split huggingface dataset:
İçmeler Kanyonu (Marmaris/Muğla) akarsu yatak çukurlarının jeomorfosit potansiyeli ve turizmde değerlendirilmesi
Authors: POLAT Selahattin , EGE İsmail , ÖZKAN Efekan 
Published: July 2023

Çağımızdaki turizm anlayışı değişmekte, turizm faaliyetleri giderek çeşitlenmektedir. Türkiye’de kıyı turizmi odaklı büyümenin yanında alternatif turizm faaliyetlerine de ilgi duyulmakta, çeşitli temalardaki varlıkların tanıtımı ve değerlendirilmesi noktasında yatırımlar yapılmaktadır. Dünya genelinde ekoturizm ile birlikte değerlendirilen jeosit ve jeomorfositler, özgün, estetik, nadir bulunan güzellikleri ve bilimsel değer sunmaları açısından önemli konuma ulaşmıştır. Sürdürülebilir turizm anlayışının tüm turizm faaliyetlerini yönlendiren ve dönüştüren bir olgu olarak ön plana çıkması, jeomorfositlerin turizm amaçlı değerlendirilebilmesinin önünü açmaktadır. Deniz-kum-güneş temasıyla ön plana çıkan kıyılarının yanı sıra birçok doğal güzelliğe de ev sahipliği yapan Marmaris ilçesi çok sayıda yerli ve yabancı turistin ziyaret ettiği, Türkiye ve Akdeniz Havzası’nın önemli bir turizm merkezidir. Bu çalışmada, Marmaris’in İçmeler Mahallesi sınırları içinde yer alan İçmeler Kanyonu’nda tespit edilen jeomorfolojik ve estetik değer sunan sekiz adet akarsu yatak çukurundan en belirgin olan dördünün jeolojik-jeomorfolojik ve morfometrik özellikleri tespit edilmiş, daha sonra bu şekiller bilimsel, görsel/estetik, tarihi-kültürel ve sosyoekonomik değer başlıklarıyla Prolong yöntemine göre ele alınmış, ilgili literatüre uygun puanlama ile Vtour skoru elde edilmiştir. Ardından bu sonuçları güçlendirebilmek için Güçlü, Zayıf, Fırsat ve Tedbirler (GZFT) analizine başvurulmuştur. Bu değerlendirmeler sonucunda söz konusu yatak çukurlarının özellikle görsel ve bilimsel anlamda orta-üstü öneme sahip olduğu anlaşılmıştır. Marmaris’in sahip olduğu bu doğal güzelliğin/çekiciliğin coğrafi önemi ve özgünlüğünün kavranarak jeomorfosit olarak tanımlanması/tanıtılması, bu doğrultuda yetkili kurumlarca tabiat anıtı olarak ilan edilmesi gibi somut adımların atılması gerekmektedir. Bu çerçevede; söz konusu şekillerin başta yöre ekonomisi açısından önemli olan turizme çeşitlilik ve katma değer sağlayabileceği, Anadolu’daki farklı özgün jeomorfolojik şekillerin de bu kapsamda değerlendirilebilmesi adına bir gösterge sunabileceği düşünülmektedir.
Anahtar Sözcükler: Marmaris, İçmeler Kanyonu, Akarsu yatak çukurları, Jeomorfosit, Turizm.
Verification of Roche reference ranges for serum prolactin in children, adolescents, adults, and the elderly
Authors: Ilardo Claudio , Coulon Guillaume , Ehrhard Yoann , Barthes Joel 
Published: July 2023

Reference intervals (RIs) for prolactin are of high clinical importance for diagnosis, treatment, and prognosis of hypothalamic-pituitary disorders. The aim of this study was to verify the Roche reference ranges for serum prolactin in children, adolescents, adults, and the elderly. : An indirect method based on currently laboratory data was used on the reference ranges. Nine thousand one hundred and thirteen prolactin results were included. Pregnancy, lactation, exercise and reported pathologies were ruled out and only samples were collected between 8AM and 12PM were used. Reference ranges with a confidence interval of 95% (95% CI) were estimated. : Compared to the manufacturer's reference values and for the corresponding age group, the median values obtained in our study were 10 – 60% higher depending on the age and sex of the patients. Elevated levels of serum prolactin were observed in the neonatal period and values decrease until median values near 200 mUI/L in childhood. During the children's period, no gender differences were observed for prolactin level. The gender difference in prolactin levels became significant from pre-adolescence until the age of 60. Prolactin levels increased significantly (p&#60;0.001) between children and young adults, followed by a gradual and continuous decrease until young senior age.: The prolactin reference values proposed by the manufacturer in the data sheet appeared unsuitable. Laboratories should review reference ranges, and a partitioning with sex and different age groups may be appropriate.
Genetic polymorphism of high-molecular-weight glutenin subunit loci in bread wheat varieties in the Pre-Ural steppe zone
Authors: Galimova A. A. , Kuluev A. R. , Ismagilov K. R. , Kuluev B. R. 
Published: July 2023

High-molecular-weight glutenins play an important role in providing high baking qualities of bread wheat grain. However, breeding bread wheat for this trait is very laborious and, therefore, the genotyping of variety samples according to the allelic composition of high-molecular-weight glutenin genes is of great interest. The aim of the study was to determine the composition of high-molecular-weight glutenin subunits based on the identification of the allelic composition of the Glu-1 genes, as well as to identify the frequency of the Glu-1 alleles in bread wheat cultivars that are in breeding work under the conditions of the Pre-Ural steppe zone (PSZ). We analyzed 26 winter and 22 spring bread wheat varieties from the PSZ and 27 winter and 20 spring varieties from the VIR collection. Genotyping at the Glu-A1 locus showed that the Ax1 subunits are most common in winter varieties, while the predominance of the Ax2* subunits was typical of spring varieties and lines. In the Glu-B1 locus, the predominance of alleles associated with the production of the Bx7 and By9 subunits was revealed for both winter and spring varieties. In the case of the Glu-D1 gene, for all the wheat groups studied, the composition of the Dx5+Dy10 subunits was the most common: in 92.3 % of winter and 68.2 % of spring PSZ accessions and in 80 % of winter and 55 % of spring VIR accessions. The analysis of genotypes showed the presence of 13 different allelic combinations of the Glu-A1, Glu-B1, Glu-D1 genes in the PSZ varieties, and 19 combinations in the VIR varieties. The b b/al/с d allelic combination (Ax2* Вх7+Ву8/8*/9 Dx5+Dy10) turned out to be the most common for the PSZ spring varieties and lines, while for the PSZ winter accessions it was a с d (Ax1 Вх7+By9 Dx5+Dy10); the b с a and b с d genotypes (Ax2* Вх7+Ву9 Dx2+Dy12 and Ax2* Вх7+Ву9 Dx5+Dy10, respectively) occur with equal frequency among the VIR spring accessions; in the group of VIR winter varieties, the combination of the a b/ al d alleles (Ax1 Вх7+Ву8/8* Dx5+Dy10) prevails. The most preferred combination of alleles for baking qualities was found in the spring variety ‘Ekaterina’ and winter varieties ‘Tarasovskaya 97’, ‘Volzhskaya S3’, as well as in lines k-58164, L43510, L43709, L-67, L-83, which are recommended for further breeding programs to improve and preserve baking qualities in the conditions of the Pre-Ural steppe zone.
Creation and study of emmer (<i>Triticum dicoccum</i>) × triticale hybrids
Authors: Silkova O. G. , Ivanova Y. N. , Stepochkin P. I. 
Published: July 2023

Triticale (× Triticosecale Wittmack) is of great interest as an insurance crop that can ensure the stability of the gross harvest of feed and food grains at a lower cost. In Western Siberia, only winter triticale varieties are cultivated, however, spring triticales are important for cultivation in regions not suitable for winter crops. To create spring varie ties with high yields and good grain quality, it is necessary to study and enrich the gene pool, identify donors of economically valuable traits. One of the possible ways to solve this problem can be through the production of secondary hexaploid triticales with the involvement of the tetraploid wild-growing species of emmer wheat Triticum dicoccum (Schrank) Schuebl. The aim of this work was to create and study hybrids of emmer T. dicoccum (Schrank) Schuebl. with hexaploid triticale using genomic in situ hybridization for staining of meiotic chromosomes and analysis of plant productivity elements in F4–F8. DT4, DT5, DT6 plants and the prebreeding F6 forms obtained from them – DT 4/168, DT 5/176 and DT 6/186 – were selected according to the characteristics of the productivity and the nature of the grain in the F4 hybrid population. The offspring of hybrids DT4 and DT5 and prebreeding forms DT 4/168 and DT 5/176 had an increased grain nature (over 750 g/l), but low productivity. The hybrid DT6 and the breeding form DT 6/186 obtained from it had high grain productivity (785 ± 41 and 822 ± 74 g/m2, respectively), but, like the paternal form of triticale UK 30/33, had a reduced nature of the grain. In F8 DT 6/186 plants, 7 homologous pairs of rye chromosomes and from 27 to 30 wheat chromosomes were found in meiosis, which indicates the presence of a complete rye genome and two wheat ААВВ genomes. Rye chromosomes showed stable formation of bivalents in contrast to wheat chromosomes, which caused the presence of aneuploids in plant populations. Thus, hexaploid forms DT 4/168 and DT 5/176 with well-made smooth grain and high grain size were obtained, which can be used as a source of this trait for selection of food-grade triticale. DT 6/186 is a promising form for further breeding in order to obtain high-yielding forms of triticale.
Genetic methods in honey bee breeding
Authors: Kaskinova M. D. , Salikhova A. M. , Gaifullina L. R. , Saltykova E. S. 
Published: July 2023

The honey bee Apis mellifera is a rather difficult object for selection due to the peculiarities of its biology. Breeding activities in beekeeping are aimed at obtaining bee colonies with high rates of economically useful traits, such as productivity, resistance to low temperatures and diseases, hygienic behavior, oviposition of the queen, etc. With two apiaries specializing in the breeding of A. m. mellifera and A. m. carnica as examples, the application of genetic methods in the selection of honey bees is considered. The first stage of the work was subspecies identification based on the analysis of the polymorphism of the intergenic mtDNA locus tRNAleu-COII (or COI-COII) and microsatellite nuclear DNA loci Ap243, 4a110, A24, A8, A43, A113, A88, Ap049, A28. This analysis confirmed that the studied colonies correspond to the declared subspecies. In the apiary with A. m. mellifera, hybrid colonies have been identified. A method based on the analysis of polymorphisms of the tRNAleu-COII locus and microsatellite nuclear DNA loci has been developed to identify the dark forest bee A. m. mellifera and does not allow one to differentiate subspecies from C (A. m. carnica and A. m. ligustica) and O (A. m. caucasica) evolutionary lineages from each other. The second stage was the assessment of the allelic diversity of the csd gene. In the apiary containing colonies of A. m. mellifera (N = 15), 20 csd alleles were identified. In the apiary containing colonies of A. m. carnica (N = 44), 41 alleles were identified. Six alleles are shared by both apiaries. DNA diagnostics of bee diseases showed that the studied colonies are healthy. Based on the data obtained, a scheme was developed for obtaining primary material for honey bee breeding, which can subsequently be subjected to selection according to economically useful traits. In addition, the annual assessment of the allelic diversity of the csd gene will shed light on the frequency of formation of new allelic variants and other issues related to the evolution of this gene.
The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin
Authors: Belenkaya S. V. , Shcherbakov D. N. , Chapoval A. I. , Esina T. I. , Elchaninov V. V. 
Published: July 2023

The milk-clotting enzyme chymosin is a member of the group of aspartate proteinases. Chymosin is the main component of rennet traditionally obtained from the stomachs of dairy calves and widely used to coagulate milk in the production of various types of cheese. Another source of chymosin, which does not require the killing of animals, is based on recombinant DNA technology. Recombinant alpaca chymosin has a number of valuable technological properties that make it attractive for use in cheese-making as an alternative to recombinant bovine chymosin. The purpose of this work is to study the effect of coexpression of thioredoxin and prochymosin on the refolding of the recombinant zymogen and the activity of alpaca chymosin. To achieve this goal, on the basis of the pET32a plasmid, an expression vector was constructed containing the thioredoxin A gene fused to the N-terminal sequence of the marker enzyme zymogen, alpaca prochymosin. Using the constructed vector, pETTrxProChn, a strain-producer of the recombinant chimeric protein thioredoxin-prochymosin was obtained. The choice of prochymosin as a model protein is due to the ability of autocatalytic activation of this zymogen, in which the pro-fragment is removed, together with the thioredoxin sequence attached to it, with the formation of active chymosin. It is shown that Escherichia coli strain BL21 transformed with the pET-TrxProChn plasmid provides an efficient synthesis of the thioredoxin-prochymosin chimeric molecule. However, the chimeric protein accumulates in inclusion bodies in an insoluble form. Therefore, a renaturation procedure was used to obtain the active target enzyme. Fusion of thioredoxin capable of disulfide-reductase activity to the N-terminal sequence of prochymosin provides optimal conditions for zymogen refolding and increases the yield of recombinant alpaca chymosin immediately after activation and during long-term storage by 13 and 15 %, respectively. The inclusion of thioredoxin in the composition of the chimeric protein, apparently, contributes to the process of correct reduction of disulfide bonds in the prochymosin molecule, which is reflected in the dynamics of the increase in the milk-clotting activity of alpaca chymosin during long-term storage.
The Use of Diagnostic Test for Islamic Education Subject in The Affective Domain Assessment
Authors: Ismail Fajri 
Published: July 2023

The affective domain is one of the abilities that is difficult to measure in learning, mainly because it is difficult to find the proper assessment technique. This article described about the the use of diagnostic assessment for measuring students’ affective learning outcomes in Islamic Religious Education subject. The research was conducted at SD Negeri 85, Palembang. The method used in this research was quantitative method. The sample for this research was 25 sixth-grade students. Data were collected by using diagnostic test and observation. The data analysis technique used was quantitative descriptive analysis, in which the results of the diagnostic tests obtained from 25 students were scored and then calculated using descriptive statistics on each assessment indicator and percentages. The results showed that the highest ability in students’ affective domain was in the willingness to accept indicator with the result of 99% and the lowest in the belief indicator with the result of 53%. Therefore, diagnostic tests could be used to measure the learning outcomes of Islamic Religious Education (PAI) in the affective domain.
Multimodal Traveling with Rail and Ride-sharing: Lessons Learned during Planning and Demonstrating a Pilot Study
Authors: Mitropoulos Lambros , Kortsari Annie , Apostolopoulou Emy , Ayfantopoulou Georgia , Deloukas Alexandros 
Published: July 2023

Multimodal traveling is expected to enhance mobility for users, reduce inequalities of car ownership and reduce emissions. In the same context, ride-sharing aims to minimize negative impacts related to emissions, reduce travelling costs and congestion, and increase passenger vehicle occupancy, and public transit ridership when planned for first/last mile trips. The goal of this study is to present the planning of a multimodal pilot demonstration and the challenges that emerged during and after its implementation in Athens, Greece. The demo aims to enhance the connection of low-density Attica Region areas to public transport (PT) modes, and specifically to the metro, through the provision of demand responsive ride-sharing services. During the demo period two different applications were utilized: the “Travel Companion” app and the “Driver Companion” app, which refer to passengers and drivers of the ride-sharing service. Identification of demo participants is performed through a Stated Preference (SP) experiment. Results of the demo implementation, as well as challenges that were faced show that although participants are willing to try new mobility solutions, the readiness and reliability of the new service are essential attributes towards maintaining existing users and engaging new ones.
Emotional Distress in Portuguese Cancer Patients: The Use of the Emotion Thermometers
Authors: Silva Sónia , Paredes Tiago , Teixeira Ricardo João , Brandão Tânia , Dimitrovová Klára , Marques Diogo , Sousa Joana , Leal Monick , Dias Albina , Neves Carole , Marques Graciete , Amaral Natália 
Published: July 2023

Cancer patients may experience significant distress. The “Emotion Thermometers” (ETs) are a short visual analogue scale used to screen patients for psychosocial risk. This study aimed to assess emotional distress in a large sample of cancer patients attending psychological services at an NGO, and to explore factors that may contribute to it.
The ETs were answered by 899 cancer patients. They were, on average, 59.9 years old, the majority were female, had breast cancer, were under treatment or were disease-free survivors, and reported high levels of emotional distress, above the cut-off (≥5). A Generalized Linear Model was used to measure the association between the level of Distress and 33 items of the problem list. Four items - sadness, depression, sleep and breathing - were found to be significantly related to a higher level of Distress. Additionally, women and those who were in the palliative phase also had significantly higher levels of Distress.
Conclusions: The results confirm the need for early emotional screening in cancer patients, as well as the relevance of attending to the characteristics of each patient. Additionally, they highlight the utility of the ETs for the clinical practice, allowing to optimize the referral to specialized psy-chosocial services.
Remission Induction with Tacrolimus for Intractable Ulcerative Colitis: A Retrospective Study of Remission Rates, Maintenance at 52 Weeks, Drug-Specific Maintenance, and Safety
Authors: Ito Ayumi , Murasugi Shun , Omori Teppei , Nakamura Shinichi , Tokushige Katutoshi 
Published: July 2023

Background and Aim: Tacrolimus is highly effective in intractable ulcerative colitis, but maintenance may be problematic. This study examined 52-week maintenance and adverse events.
Methods: This retrospective study of patients who used tacrolimus from April 2009 to December 2021 (N = 136) examined remission induction rates and background factors in the remission (n = 108) and non-remission groups (n = 28); 52-week maintenance; drug-specific maintenance (azathioprine [n = 58] vs tacrolimus [n = 12] and vs biological product [Bio, n = 8]); and adverse events.
Results: The mean observation period was 1230175 days. Remission occurred in 72.7%. Significant differences were observed in sex and endoscopic score (before treatment and 2 weeks after tacrolimus trough levels). Maintenance rate at 52 weeks was 61.6%; significant differences were observed in sex, hospitalization duration, and prednisolone during hospitalization (P &lt; 0.05). Drug-specific 52-week maintenance was 67% with azathioprine, 54% with tacrolimus, and 37% with Bio. No tacrolimus-related serious adverse events occurred that led to discontinuation.
Discussion: Remission was more common in women with improved endoscopic scores after tacrolimus trough levels and patients with improved endoscopic scores after tacrolimus therapy. Remission maintenance was more common in women with a long hospitalization at remission and high total steroid dose. Results suggest that treatment with adequate prednisolone use during the period with more inflammation may improve subsequent maintenance.
Conclusions: In intractable ulcerative colitis, tacrolimus can induce remission even in patients who cannot use azathioprine for maintenance. Remission can be maintained with azathioprine, tacrolimus, or a Bio.
Servant Leadership and Work Engagement among Contractual Employees
Authors: Putra Dhaifan Dewanda , Wicaksono Bagus , Satwika Pratista Arya 
Published: July 2023

<p><em>Several studies have found a correlation between servant leadership and work engagement, but a more in-depth study is still needed to analyze the relationship between the two in different research subjects, namely, honorary employees. This study aims to determine the relationship between servant leadership and work engagement among honorary employees. All respondents consist of 72 honorary employees selected using the total sample technique. The instruments used are the Utrecht Work Engagement Survey (UWES) and the Servant Leadership Scale. The results of the Spearman rank correlation test in this study show a correlation coefficient value of 0.559 (p &lt; 0.05), which can be interpreted as a significant positive relationship between servant leadership and work engagement among honorary employees.</em></p><p> </p>
Pengaruh Pelatihan Kerja, Penempatan Posisi Kerja Dan Etika Kerja Islam Terhadap Produktivitas Kerja Pegawai (Studi Pada Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Provinsi Kalimantan Timur)
Authors: Putri Rizki Sintia , Nurzaroni Akhmad , Hamidy Anwaril , Hasbi Muhamad 
Published: July 2023

ABSTRAK
Produktivitas merupakan ukuran yang sering digunakan untuk menentukan efektivitas suatu organisasi ataupun instansi.Tinggi atau rendahnya produktivitas organisasi ataupun instansi dilihat dari hasil yang dicapai (output) dengan input yang digunakan, artinya ada peningkatan efisiensi (waktu-bahan-tenaga), dan sistem kerja atau keterampilan tenaga kerjanya. Namun apabila efisiensi kerja pegawai tidak meningkat maka organisasi ataupun instansi tidak akan bisa berkembang. Salah satu ukuran keberhasilan DPMPTSP Provinsi Kalimatan Timur dalam upaya pencapaian tujuannya adalah meningkatnya produktivitas kerja pegawai yang dimana secara langsung berdampak pada kemajuan atau semakin berkembangnya DPMPTSP Provinsi Kalimatan Timur. Tercapainya suatu tingkat produktivitas tersebut tentunya dipengaruhi oleh berbagai faktor, hal yang menarik untuk diperhatikan yaitu mengenai pelatihan kerja, penempatan posisi kerja dan etika kerja Islam. Penelitian ini bertujuan buat mengetahui pengaruh pelatihan kerja, penempatan posisi kerja, dan etika kerja Islam terhadap produktivitas kerja pegawai pada DPMPTSP Provinsi Kalimantan Timur.
Jenis penelitian ini adalah metode penelitian kuantitatif. Penelitian ini merupakan penelitian survei yang mana pengambilan data populasinya yaitu seluruh pegawai DPMPTSP Provinsi Kalimantan Timur yang beragama Islam dengan jumlah 48 orang. Sampel yang digunakan pada penelitian ini ialah sampling jenuh. Teknik pengumpulan datanya menggunakan kuesioner. Teknis analisis data yang digunakan adalah analisis regresi linier berganda menggunakan SPSS tipe 21 For Windows.
Hasil penelitian ini menunjukkan bahwa variabel pelatihan kerja berpengaruh signifikan terhadap produktivitas kerja karena memiliki nilai thitung 2,602 > ttabel 2,059. Sedangkan variabel penempatan posisi kerja tidak berpengaruh signifikan terhadap produktivitas kerja karena memiliki nilai sig. sebesar 0,306 > 0,05 dan nilai thitung -1,045 < ttabel 2,059. Dan variabel etika kerja Islam tidak berpengaruh signifikan terhadap produktivitas kerja karena memiliki nilai sig. 0,175 > 0,05 dan thitung sebesar 1,412 < ttabel 2,059. Pelatihan kerja, penempatan posisi kerja dan etika kerja Islam secara simultan berpengaruh signifikan terhadap produktivitas kerja karena tingkat nilai signifikan pelatihan kerja, penempatan posisi kerja dan etika kerja Islam sebesar 0,021 < 0,05 atau nilai Fhitung 3,858 > Ftabel 2,93. Koefisien determinasi menunjukkan bahwa ketiga variabel indepeden berpengaruh sebesar 22,8% terhadap variabel dependen sedangkan sisianya sebesar 77,2% dipengaruhi oleh variabel lain yang tidak digunakan dalam penelitian ini.