bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma—A Controversial and Pathologically Challenging Low‐Grade Sarcoma
Authors: Hirose Takeshi , Chang Hsin‐Yi , Saoud Carla , Lefkowitz Robert A. , Athanasian Edward , Antonescu Cristina R. 
Published: January 2025

ABSTRACTPurposeMyxoinflammatory fibroblastic sarcoma (MIFS) is a rare, low‐grade sarcoma affecting with predilection the acral soft tissues of middle‐aged adults. Clinically, MIFS is associated with a high rate of local recurrence but infrequent distant metastases. The diagnosis remains challenging due to their wide histologic spectrum and overlap with reactive, benign, and low‐grade malignant lesions. Moreover, a significant limitation is that molecular confirmation is achieved in only a subset of cases, due to its broad range of genetic alterations which requires a multiplatform approach. Thus, a definitive diagnosis, especially at nonacral sites and in molecularly negative cases, remains uncertain. Our goal was to perform a detailed clinicopathologic and molecular reappraisal of MIFS managed at a single tertiary cancer center with dedicated orthopedic oncology expertise. Additionally, we examined potential outcomes correlating with specific genetic alterations.Patients and MethodsA cohort of 33 patients (12 males, 21 females, median age 52 years) was selected. Tumors were tested by FISH, Archer, and/or targeted NGS.ResultsVGLL3 amplification was detected in 84%, BRAF fusions in 33% and combined TGFBR3/MGEA5 rearrangements in 32% of cases. Two novel fusions were detected, RRAGB::CCNB3 and FGFR1::ZBTB47. Other events included a YAP1::MAML2 fusion in two cases, one co‐existing with a BRAF fusion. Overall, 8 (24%) patients recurred, 4 more than once, while 4 (12%) patients developed metastasis (3 locoregional, 1 pulmonary), all associated with VGLL3 gene amplification.ConclusionPositive margin status was associated with increased recurrence and reduced disease‐free survival (DFS, p = 0.02). Moreover, it emphasizes the impact of multiplatform molecular testing in confirming the diagnosis. The lack of both local recurrence and metastatic potential outside VGLL3 amplifications requires further investigation.
Sources and Enrichment Mechanisms of Li‐Rich Geothermal Springs in the Mediterranean‐Himalayan Belt: Modelling From Li Isotope and Hydrochemistry
Authors: Zhu Hongkai , Tan Hongbing , Cong Peixin , Shi Zhiwei 
Published: January 2025

ABSTRACTThe eastern extension of the Mediterranean‐Himalayan geothermal belt contains numerous geothermal springs with anomalously high lithium (Li) content. These springs have long discharged substantial Li resources to the surface, underscoring their potential as a Li‐rich geological feature of significant interest. This study utilises field investigations of typical high‐temperature, Li‐rich geothermal springs in this region, along with Li isotope tracing, hydrogeochemical analysis, and simulation, to elucidate the mechanisms behind the anomalous Li enrichment in these springs and to establish a model for Li enrichment in geothermal systems. Our findings reveal that high‐temperature geothermal springs along the Yarlung Tsangpo Suture Zone in Tibet exhibit the highest recorded Li concentrations, generally exceeding those in other geothermal springs in the eastern extension by 1–2 orders of magnitude, with some even reaching concentrations suitable for industrial extraction. The discrepancy between the δ7Li values calculated for the geothermal springs and those measured, as well as the water–rock interactions simulated by PHREEQC, suggests that the Li leached solely from surrounding rocks is insufficient to account for the observed concentrations, indicating the presence of additional Li sources. In conclusion, the anomalous Li enrichment observed in these springs results from a combination of deep magmatic fluids, regionally Li‐enriched rocks, and intense water–rock interactions. The upwelling of residual magmatic fluids from partial crustal melting along the Yarlung Tsangpo Suture Zone plays a major role in forming geothermal springs with unusually high Li content. In contrast, springs formed by mantle‐derived magma, volcanism, or solely by water–rock interactions generally show only slight Li enrichment.
Impact of severe intra‐abdominal adhesions on early maternal complications following cesarean delivery
Authors: Ram Shai , Shalev‐Ram Hila , Alon Shira , Trigerman Shai , Many Ariel , Yogev Yariv , Attali Emmanuel 
Published: January 2025

AbstractObjectiveThe rising rates of cesarean delivery (CD), which are a leading cause of intra‐abdominal adhesions, represent a major concern for maternal health. We aimed to describe early maternal complications following CD in women with severe intra‐abdominal adhesions.MethodsA prospective observational study was conducted at a university‐affiliated tertiary medical center (January 2021 and March 2023) in Israel. Women who underwent CD were assessed for intra‐abdominal adhesions by questionnaires completed by the surgeons. Adhesions were evaluated at four anatomical sites: abdomen‐to‐uterus, uterus‐to‐bladder, skin‐to‐fascia, and other intra‐abdominal sites. Each site was scored on a scale of 0–2, with a total score ranging from 0 to 8. Severe adhesions were defined as a total score ≥5. The primary outcome measures were a composite complication which included at least one or more of postoperative need for blood or iron products, fever, prolonged hospitalization, re‐hospitalization, and emergency room visits.ResultsOverall, 2797 women were included in the study, of whom 295 (10.6%) exhibited severe adhesions. Women with severe adhesions had a higher composite risk for maternal complications following CD (RR = 1.28, 95% confidence interval [CI]: 1.12–1.45, P < 0.001), specifically, postoperative need for blood or iron products (RR = 1.71, 95% CI: 1.15–2.55, P = 0.007) and prolonged hospitalization (RR = 1.49, 95% CI: 1.10–2.03, P = 0.009). There were no significant group differences in the rates of postoperative fever, re‐hospitalization or emergency room visits. In multivariate analysis, severe adhesions had an independent impact on maternal complications (CI: 1.06–1.95, P value 0.017).ConclusionSevere intra‐abdominal adhesions diagnosed in CD had an impact on early maternal complications.
Unveiling complexities: Examining the role of traumatic loss in shaping the interplay between black maternal mental health and maternal bonding
Authors: Quince Helenia , Walsh Tova , Thomas Alvin , Blackwell Dalvery 
Published: January 2025

AbstractBlack women are more likely to experience traumatic birthing events, more likely to experience perinatal depression, and less likely to receive mental health treatment than women of other racial and ethnic backgrounds, and yet largely overlooked in perinatal mental health research. This pilot study seeks to understand how unacceptable racial disparities and adverse perinatal outcomes influence Black maternal depression and maternal bonding by exploring how prior traumatic loss moderates the relationship between depression and bonding during a subsequent pregnancy among a sample of Black mothers. We use survey data collected from 75 Black mothers as part of the Black Fathers, Equal Partners in Promoting Maternal and Infant Health study, a collaboration between the University of Wisconsin Madison and the African American Breastfeeding Network in Milwaukee, Wisconsin, USA. Study results suggest there is a correlation between maternal depression and bonding; when traumatic loss is included as an interaction variable, it produces a moderating effect, changing the direction of the relationship between bonding and depression. As maternal depression increases, bonding increases when moderated by the variable traumatic loss. This finding has important implications for infant mental health research and practice, disrupting the expectation that depression necessarily poses a risk to maternal–infant bonding.
Consumers' sensory assessments of bigleaf maple (Acer macrophyllum) syrup give way to a promising artisan industry
Authors: Colonna Ann E. , Jones Eric T. , Wheiler Kent 
Published: January 2025

AbstractBackgroundMost pure maple syrup produced in North America is produced from the sap of sugar maple trees (Acer saccharum). Interest is growing to utilize other maple species in different regions of North America outside the native range of sugar maple. This research assesses a maple syrup produced in one of these regions, bigleaf maple (Acer macrophyllum) from the Pacific Northwest. Two blind‐coded consumer‐sensory evaluations, which took place in May 2022 and 2023, were conducted with 411 participants to assess overall sensory hedonics and descriptors, quality ratings, purchase intent, and perceptions of the syrup category with 13 unique samples of bigleaf maple, sugar maple (A. saccharum), and imitation maple syrup.ResultsTwo bigleaf maple syrups were rated highest in overall liking. Of the syrups tested, several of the bigleaf maple syrups were rated as having the most complex flavor profile. When consumers were segmented on overall liking, flavor complexity intensity was positively correlated (p < 0.05) with perceived quality, purchase intent, and overall liking for the larger cluster of consumers (n = 154), though there seems to be an optimum level over which the syrup can then be penalized for being too complex. A correspondence analysis (CA) showed the syrups that were most well‐liked exhibited qualities “maple,” “sweet,” “caramel,” “nutty,” “honey,” “vanilla,” and “fragrant.”ConclusionThis research demonstrates that quality bigleaf maple syrup is a well‐liked product of interest and has high potential for commercial success.
Cross‐ecosystem trophic structure and benthic–pelagic coupling: Effects of depth, body size, and feeding guild
Authors: Walters Andrea , Kopp Dorothée , Cresson Pierre , Robert Marianne 
Published: January 2025

AbstractUnderstanding how energy is transferred within and across ecosystems is essential to better understand drivers and future consequences of shifts in energy pathways. We used stable isotope ratios of 1932 fish individuals belonging to the 11 most abundant fish species collected across 300,000 km2 along the English Channel–Celtic Sea continuum. To examine cross‐ecosystem differences in trophic functioning, we assessed the effects of both extrinsic (depth) and intrinsic factors (body size and feeding guild) on resource use and trophic position of fish consumers. Positive relationships between trophic position and body size were observed for zoobenthivore and piscivore fishes, whereas the relationship was negative for benthivore fishes. Body size is thus an important structuring mechanism in the systems. Trophic position decreased with increasing depth for all levels of biological organization. The amplitude of the change between shallow and deep stations was equivalent to more than one trophic level for generalist planktivores and piscivores. In the shallow English Channel, the food web is marked by stronger coupling of benthic and pelagic habitats via diverse pathways, due to the proximity of benthic and pelagic species, whereas in the Celtic Sea, increasing depth leads to a decoupling of benthic and pelagic pathways. For piscivores, a consistent pattern of increasing dependence on benthic subsidies with increasing size and depth highlights the importance of large consumers coupling energy across food web compartments. This study describes the relationship between production and trophic functioning and provides an empirical ecological explanation for cross‐ecosystem differences in observed trophic structures.
Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI‐RS 2024
Authors: Van den Ende Mauro , Apostolidis Apostolos , Sinha Sanjay , Kheir George Bou , Mohamed‐Ahmed Rayan , Selai Caroline , Abrams Paul , Vrijens Desiree 
Published: January 2025

ABSTRACTAimsTo discuss the role of screening and treatment of affective symptoms, like anxiety and depression in patients with LUTD. A review of the literature regarding the bidirectional association and multidisciplinary approaches integrating psychometric assessments with personalized treatment plans to improve diagnostic accuracy and therapeutic outcomes of LUTD.MethodsThis review summarizes discussions and a narrative review of (recent) literature during an International Consultation on Incontinence‐Research Society 2024 research proposal with respect to the role of screening for anxiety and depression, effect of mental health symptoms on treatment outcomes and future implications.ResultsConsensus recognized the importance to incorporate attention to anxiety and depression in relation to LUTD. The awareness of this association can lead to better outcomes. Future research projects are proposed to evaluate the bidirectional relationship.ConclusionThe relationship between affective symptoms and LUTD underscores the need for integrated treatment approaches that address both psychological and urological dimensions. Further research is required to identify specific patient subgroups that would benefit most from these interventions, to develop standardized screening tools, and to refine treatment protocols. Multidisciplinary care, incorporating psychological assessment and personalized treatment strategies, could enhance outcomes for LUTD patients.
Multi‐Phase Optimal Control Problems for Efficient Nonlinear Model Predictive Control With acados
Authors: Frey Jonathan , Baumgärtner Katrin , Frison Gianluca , Diehl Moritz 
Published: January 2025

ABSTRACTComputationally efficient nonlinear model predictive control (NMPC) relies on elaborate discrete‐time optimal control problem (OCP) formulations trading off accuracy with respect to the continuous‐time problem and online computational burden. Such formulations, however, are in general not easy to implement within specialized software frameworks tailored to numerical optimal control. This article introduces a new multi‐phase optimal control problem (MOCP) interface for the open‐source software acados allowing to conveniently formulate such problems and generate fast solvers that can be used for NMPC. While multi‐phase OCP formulations occur naturally in many applications, such as, for example, walking robots, this work focuses on MOCP formulations that can be used to efficiently approximate standard continuous‐time OCPs in the context of NMPC. To this end, the article discusses advanced control parametrizations, such as closed‐loop costing and piecewise polynomials with varying degree, as well as partial tightening and formulations that leverage models of different fidelity. An introductory example is presented to showcase the usability of the new interface. Finally, three numerical experiments demonstrate that NMPC controllers based on multi‐phase formulations can efficiently trade off computation time and control performance.
Investigation of the effect of nano‐SiO2 modified by 3‐aminopropyltriethoxysilane on biobased polyamide 56 crystallization behavior
Authors: Pei Xiaoyuan , Zhu Yidong , Li Tianjiao , Wang Chunhong , Li H. anyu , Sofiene Mokhtar , Guo Xiaowei 
Published: January 2025

AbstractBio‐based polyamide 56 (PA56), a sustainable alternative to petroleum‐based polyamide 66 (PA66), exhibits a slow crystallization rate that poses a significant challenge to its broader application. The modification of SiO2 using 3‐aminopropyltriethoxysilane (APTES) can markedly enhance its dispersion and interfacial compatibility, thereby improving the mechanical interlocking effect of the material. In this study, unmodified nano‐SiO2 (UMS)/PA56 and APTES modified nano‐SiO2 (AMS)/PA56 composite materials were synthesized through melt blending technology. The non‐isothermal and isothermal crystallization kinetics of PA56 composites were analyzed by x‐ray diffraction and differential scanning calorimetry, and the effects of different SiO2 addition ratios on the crystalline properties were investigated. Experimental results indicate that as the proportion of UMS increases, the crystallization behavior of the composite material gradually weaks; conversely, the addition of AMS results in an enhanced crystallization behavior. Notably, at a cooling rate of 10°C/min, the crystallization rate (Zt) of AMS and UMS composites increased by 135% and 122%, respectively, compared to pure PA56, while the semi‐crystallization time (t1/2) decreased by 24.4% and 23.6%, respectively.Highlights
APTES modifies nano‐SiO2 to improve its dispersion.
The crystallization rate of AMS composite was increased by 135%.
The half‐crystallization time of AMS composite was reduced by 24.4%.
Compatibilization and reinforcement of highly filled wood flour/polyethylene composites via peroxide‐induced grafting and crosslinking
Authors: Li Daoan , Yi Shunmin , Liu Wanyu , Lan Ping , Liu Zhonglin , Cai Liang , Mo Min , Bai Xingjia , Huang Zhimin 
Published: January 2025

AbstractThe industrialized development of biocomposites effectively promotes the high‐value utilization of waste biomass resources, generating substantial economic benefits. However, in highly filled systems (≥50 wt.%), wood flour agglomeration and poor interfacial compatibility between components significantly degrade the performance of the final biocomposites, thus restricting their applications. In this work, we developed a low‐maleic anhydride grafted and microcrosslinking polyethylene matrices specialized for highly filled (50–70 wt.%) biocomposites for enhancing their mechanical properties. The successful grafting of maleic anhydride (MAH) onto polyethylene molecular chains and the formation of a crosslinked structure were evidenced by a characteristic infrared absorption peak at 1792 cm−1 and a new torque peak. Grafting of polyethylene matrix with MAH enhanced the adhesion between wood and matrix, as well as the dispersion of wood within the matrix. Adding a small amount of peroxide (0.09 wt.%) improved the tensile, flexural, and impact strengths of the composites by up to 120%, 125%, and 209%, respectively, compared to unmodified composites. This study proposes a simple and cost‐effective method for low grafting and microcrosslinking modification of the polyethylene matrix, and the innovative application of this method in the highly filled system of wood flour yields significant results and expands their applications in construction materials.Highlights
Matrix grafting enhances wood flour dispersion and interfacial compatibility.
Initiator‐induced crosslinking structure promotes matrix plastic deformation.
Grafting and crosslinking enhances mechanical properties of composites.
Fine wood flour particles enhance the absorption of impact energy in composites.
Unraveling the Molecular Architecture of Mosquito D1‐Like Dopamine Receptors: Insights Into Ligand Binding and Structural Dynamics for Insecticide Development
Authors: Dasgupta Subrata , Bhaumik Prasenjit 
Published: January 2025

ABSTRACTVector‐borne diseases pose a severe threat to human life, contributing significantly to global mortality. Understanding the structure–function relationship of the vector proteins is pivotal for effective insecticide development due to their involvement in drug resistance and disease transmission. This study reports the structural and dynamic features of D1‐like dopamine receptors (DARs) in disease‐causing mosquito species, such as Aedes aegypti, Culex quinquefasciatus, Anopheles gambiae, and Anopheles stephensi. Through molecular modeling and simulations, we describe the common structural fold of mosquito DARs within the G‐protein–coupled receptor family, highlighting the importance of an orthosteric and enlarged binding pocket. The orthosteric binding pocket, resembling a cage‐like structure, is situated ~15 Å deep within the protein, with two serine residues forming the roof and an aspartate residue, along with two conserved water molecules (W1 and W2), forming the floor. The side walls are composed of two phenylalanine residues on one side and a valine residue on the other. The antagonist binding site, an enlarged binding pocket (EBP) near the entrance cavity, can accommodate ligands of varying sizes. The binding energy of dopamine is observed to be ~2–3 kcal/mol higher than that of the antagonist molecules amitriptyline, asenapine, and flupenthixol in mosquito DARs. These antagonist molecules bind to EBP, which obstructs dopamine movement toward the active site, thereby inhibiting signal transduction. Our findings elucidate the molecular architecture of the binding pockets and the versatility of DARs in accommodating diverse ligands, providing a foundational framework for future drug and insecticide development.
7‐(Het)aryl‐6‐benzyloxycarbonyl Substituted Dihydro(azolo)Pyrimidines Exhibiting Activity Against Influenza A/H1N1 Virus
Authors: Filatova Elena S. , Fedorova Olga V. , Slepukhin Pavel A. , Bormotov Nikolay I. , Serova Olga A. , Skarnovich Maxim O. , Shishkina Larisa N. , Rusinov Gennady L. , Charushin Valerij N. 
Published: January 2025

AbstractA series of 7‐(het)aryl‐6‐benzyloxycarbonyl‐substituted dihydro(azolo)pyrimidines were synthesized by exploiting the multicomponent Biginelli reaction between benzyl acetoacetate, various aldehydes, aminoazoles (3‐aminopyrazole, 5‐aminotetrazole, and 3‐amino‐1,2,4‐triazole) or urea. The compounds obtained were assessed for their cytotoxicity and the antiviral activity in MDCK cell culture against the influenza virus strain A/California/04/2009 (H1N1)v (subtype A/H1N1pdm09) in comparison with the known anti‐influenza drugs rimantadine, oseltamivir, and triazide. In addition, using molecular docking, the free energies for binding of the polymerase proteins PA (polymerase acidic) and PB2 (polymerase basic) of the internal ribonucleoprotein (RNP) of influenza virus (IV) A/California/04/2009 (H1N1)v with dihydro(azolo)pyrimidines. Compounds 1a and 11 were found to be the most active against this strain of influenza virus, but the value of binding free energies of the PB2 protein for compound 11 was higher (12.55 µg/mL).
In Silico Investigation and MD Simulation Approaches of Newly Designed Quercetin–Imidazole Analogs for Anticancer and Antifungal Efficacy
Authors: Mahapatra Monalisa , Das Rohit Pritam , Pakeeraiah Kakarla , Mal Suvadeep , Panda Preetesh Kumar , Mekap Suman Kumar , Paidesetty Sudhir Kumar 
Published: January 2025

AbstractMolecules with potency and low toxicity are the leading army in the battlefield of multidrug resistance. Quercetin is found in abundance in the nature as a potent flavonoid and bears the tag of flavonoid paradox due to the poor bioavailability, however, it still possess distinct systemic actions, and this marks curiosity in the research field. The present study elaborates targeted in silico and simulation approaches of newly designed quercetin analogs toward their anticancer and antifungal properties by screening against human epidermal growth factor receptor and lanosterol C14‐alpha demethylase receptors. The molecules were investigated pharmacokinetically via drug‐likeness, toxicity prediction (lethal dose, LD50), PASS prediction, molecular docking, molecular dynamics simulation, and their quantum mechanics have been measured using molecular orbital calculations through highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) calculations. The prediction from Pa > Pi scores displayed its potential for squalene epoxide inhibitors, antimycobacterial, and antineoplastic activities and also showed prospectively better molecular docking scores against the selected targeted enzymes. Among the series, QIz II stood out as a compelling inhibitor; showcasing highest binding affinity with fungal protein by impressive docking score of −10.7 kcal/mol. Compound QIz XX demonstrated the highest binding affinity of −9.31 kcal/mol with the anticancer protein.