bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complication Rates in Therapeutic Versus Prophylactic Bilateral Mastectomies
Authors: Shaheen Mohammed S. , Wan Derrick , Momeni Arash 
Published: August 2023

Background
The “Jolie effect” and other media focus on prophylactic treatments have resulted in unilateral breast cancer patients increasingly undergoing contralateral prophylactic mastectomy. Little is known, however, regarding outcomes following therapeutic versus prophylactic mastectomy. In this study, we compared complication rates of unilateral breast cancer patients undergoing contralateral prophylactic mastectomy (BM-TP) to patients undergoing bilateral prophylactic mastectomy (BM-P).

Methods
The BM-TP and BM-P patients from 2015 to 2019 were identified in Optum Clinformatics DataMart. Six-month outcomes were assessed and included wound complications, infection, hematoma/seroma, breast pain, fat necrosis, flap failure, implant failure/removal, other flap/implant complications, and other complications. Multivariable regression models adjusted for age, residence, insurance, race, and Charlson Comorbidity Index score.

Results
Of 9319 women, 7114 (76.3%) underwent BM-TP, and 2205 (23.7%) underwent BM-P. In multivariable analysis, BM-TP had higher odds of overall complications (adjusted odds ratio [aOR], 1.35; P < 0.0001), but no difference was observed among patients who had autologous (P = 0.1448) or no breast reconstruction (P = 0.1530). Higher odds of overall complications persisted even after controlling for radiation therapy (aOR, 1.25; P = 0.0048) and chemotherapy (aOR, 1.28; P = 0.0047), but not after controlling for lymph node surgery (P = 0.7765).

Conclusion
The BM-TP (vs BM-P) patients face higher odds of overall complications but without any difference in certain reconstructive modalities or after controlling for lymph node surgery.
Lateral Septal Circuits Govern Schizophrenia-Like Effects of Ketamine on Social Behavior
Authors: Wang Ruixiang , Peterson Zeru , Balasubramanian Nagalakshmi , Khan Kanza M. , Chimenti Michael S. , Thedens Daniel , Nickl-Jockschat Thomas , Marcinkiewcz Catherine A. 
Published: August 2023

ABSTRACTSchizophrenia is marked by poor social functioning that can have a severe impact on quality of life and independence, but the underlying neural circuity is not well understood. Here we used a translational model of subanesthetic ketamine in mice to delineate neural pathways in the brain linked to social deficits in schizophrenia. Mice treated with chronic ketamine (30 mg/kg/day for 10 days) exhibit profound social and sensorimotor deficits as previously reported. Using three- dimensional c-Fos immunolabeling and volume imaging (iDISCO), we show that ketamine treatment resulted in hypoactivation of the lateral septum (LS) in response to social stimuli. Chemogenetic activation of the LS rescued social deficits after ketamine treatment, while chemogenetic inhibition of previously active populations in the LS (i.e. social engram neurons) recapitulated social deficits in ketamine-naïve mice. We then examined the translatome of LS social engram neurons and found that ketamine treatment dysregulated genes implicated in neuronal excitability and apoptosis, which may contribute to LS hypoactivation. We also identified 38 differentially expressed genes (DEGs) in common with human schizophrenia, including those involved in mitochondrial function, apoptosis, and neuroinflammatory pathways. Chemogenetic activation of LS social engram neurons induced downstream activity in the ventral part of the basolateral amygdala, subparafascicular nucleus of the thalamus, intercalated amygdalar nucleus, olfactory areas, and dentate gyrus, and it also reduces connectivity of the LS with the piriform cortex and caudate-putamen. In sum, schizophrenia-like social deficits may emerge via changes in the intrinsic excitability of a discrete subpopulation of LS neurons that serve as a central hub to coordinate social behavior via downstream projections to reward, fear extinction, motor and sensory processing regions of the brain.
Phosphorylation-Dependent Association of WRN with RPA is Required for Recovery of Replication Forks Stalled at Secondary DNA Structures
Authors: Noto Alessandro , Valenzisi Pasquale , Fratini Federica , Kulikowicz Tomasz , Sommers Joshua A. , Feo Flavia Di , Palermo Valentina , Semproni Maurizio , Crescenzi Marco , Brosh Robert M. , Franchitto Annapaola , Pichierri Pietro 
Published: August 2023

ABSTRACTThe WRN protein mutated in the hereditary premature aging disorder Werner syndrome plays a vital role in handling, processing, and restoring perturbed replication forks. One of its most abundant partners, Replication Protein A (RPA), has been shown to robustly enhance WRN helicase activity in specific cases when testedin vitro. However, the significance of RPA-binding to WRN at replication forks in vivo has remained largely unexplored. In this study, we have identified several conserved phosphorylation sites in the acidic domain of WRN that are targeted by Casein Kinase 2 (CK2). Surprisingly, these phosphorylation sites are essential for the interaction between WRN and RPA, bothin vitroand in human cells. By characterizing a CK2-unphosphorylatable WRN mutant that lacks the ability to bind RPA, we have determined that the WRN-RPA complex plays a critical role in fork recovery after replication stress whereas the WRN-RPA interaction is not necessary for the processing of replication forks or preventing DNA damage when forks stall or collapse. When WRN fails to bind RPA, fork recovery is impaired, leading to the accumulation of single-stranded DNA gaps in the parental strands, which are further enlarged by the structure-specific nuclease MRE11. Notably, RPA-binding by WRN and its helicase activity are crucial for countering the persistence of G4 structures after fork stalling. Therefore, our findings reveal for the first time a novel role for the WRN-RPA interaction to facilitate fork restart, thereby minimizing G4 accumulation at single-stranded DNA gaps and suppressing accumulation of unreplicated regions that may lead to MUS81-dependent double-strand breaks requiring efficient repair by RAD51 to prevent excessive DNA damage.
Auditory cortical error signals retune during songbird courtship
Authors: Jones Caleb , Goldberg Jesse H. 
Published: August 2023

AbstractAuditory feedback is important for vocal learning and control, but it remains unclear how the presence of an audience affects neural representations of self-produced sounds. Here we recorded neural activity in a primary auditory cortical area, Field L, in zebra finches practicing singing alone and directing courtship songs to females. We first discovered that many Field L neurons changed their singing-related discharge patterns during courtship singing, even though the auditory feedback from the bird’s own song was similar. We next used syllable-targeted distorted auditory feedback (DAF) to test how auditory error signals depend on courtship context. Though past work showed that dopamine neurons uniformly reduce error signaling during courtship, Field L neurons exhibited heterogeneous error signal re-tuning in the presence of the female. Thus, single neurons in a primary sensory area process feedback from self-produced actions differently during practice and performance.
Unpacking the role of green absorptive capacity in the relationship between green supply chain management practices and firm performance
Authors: Asamoah David , Acquah Ishmael Nanaba , Nuertey Dorcas , Agyei-Owusu Benjamin , Kumi Caleb Amankwaa 
Published: August 2023

PurposeThis study examines green absorptive capacity as an important intervening variable that elucidates the relationship between green supply chain management (GSCM) practices (specifically, green purchasing, customer cooperation and investment recovery) and firm performance.Design/methodology/approachDrawing from the theoretical underpinnings of the natural-resource-based view theory and information processing theory, a research model is developed and tested using data obtained from 368 manufacturing firms in Ghana. Data analysis was conducted using structural equation modeling.FindingsThe results indicate that green purchasing, customer cooperation and investment recovery have a direct positive and significant effect on firm performance. Additionally, green purchasing and customer cooperation have a positive and significant effect on green absorptive capacity but investment recovery does not. Further, the results show that the paths from green purchasing and customer cooperation to firm performance are positively mediated by green absorptive capacity.Practical implicationsThe study reveals to supply chain managers that green absorptive capacity is an important conduit through which firms can achieve enhanced firm performance from GSCM initiatives.Originality/valueThis study makes a contribution by integrating the absorptive capacity literature and green management literature and establishes green absorptive capacity as a mechanism through which GSCM practices enhance firm performance.
Management of environmental risks in highway construction projects in Sri Lanka
Authors: Abhayantha K.I.L. , Perera B.A.K.S. , Perera H.A.H.P. , Palliyaguru Roshani S. 
Published: August 2023

Purpose
Environmental risks (ERs) are critical to any highway construction project (HCP). One of the main contracting parties responsible for ERs is the contractor. Hence, it has been crucial to look into ways to control ERs in HCPs from the contractor’s perspective. This study aims to investigate how ERs can be managed in HCP in Sri Lanka.

Design/methodology/approach
A quantitative research approach with three rounds of Delphi was used. Statistical techniques were used to analyse and validate the ERs, the parties to whom the risks were to be allocated, and risk management measures identified from the empirical data collection.

Findings
The study reveals the 11 most significant ERs for HCP. Further, the most significant ERs in HCP were mainly found to be the responsibility of contractors in Sri Lanka. Twenty-four most appropriate risk response measures were determined; 13 were found to be common measures that could be used to manage two or more risks, while the remaining 11 were unique to specific risks.

Originality/value
Overall, this research determines the most significant ERs in HCP, the best risk allocation among the parties and appropriate risk-handling strategies and measures for each significant ERs. Additionally, the study addresses the demand for ERs management in HCP.
The MSapeMER: a symmetric, scale-free and intuitive forecasting error measure for hospitality revenue management
Authors: Schwartz Zvi , Ma Jing , Webb Timothy 
Published: August 2023

Purpose
Mean absolute percentage error (MAPE) is the primary forecast evaluation metric in hospitality and tourism research; however its main shortcoming is that it is asymmetric. The asymmetry occurs due to over or under forecasts that introduce bias into forecast evaluation. This study aims to explore the nature of asymmetry and designs a new measure, one that reduces the asymmetric properties while maintaining MAPE’s scale-free and intuitive interpretation characteristics.

Design/methodology/approach
The study proposes and tests a new forecasting accuracy measure for hospitality revenue management (RM). A computer simulation is used to assess and demonstrate the problem of asymmetry when forecasting with MAPE, and the new measures’ (MSapeMER, that is, Mean of Selectively applied Absolute Percentage Error or Magnitude of Error Relative to the estimate) ability to reduce it. The MSapeMER’s effectiveness is empirically validated by using a large set of hotel forecasts.

Findings
The study demonstrates the ability of the MSapeMER to reduce the asymmetry bias generated by MAPE. Furthermore, this study demonstrates that MSapeMER is more effective than previous attempts to correct for asymmetry bias. The results show via simulation and empirical investigation that the error metric is more stable and less swayed by the presence of over and under forecasts.

Research limitations/implications
It is recommended that hospitality RM researchers and professionals adopt MSapeMER when using MAPE to evaluate forecasting performance. The MSapeMER removes the potential bias that MAPE invites due to its calculation and presence of over and under forecasts. Therefore, forecasting evaluations may be less affected by the presence of over and under forecasts and their ability to bias forecasting results.

Practical implications
Hospitality RM should adopt this measure when MAPE is used, to reduce biased decisions driven by the “asymmetry of MAPE.”

Originality/value
The MAPE error metric exhibits an asymmetry problem, and this paper proposes a more effective solution to reduce biased results with two major methodological contributions. It is first to systematically study the characteristics of MAPE’s asymmetry, while proposing and testing a measure that considerably reduces the amount of asymmetry. This is a critical contribution because MAPE is the primary forecasting metric in hospitality and tourism studies. The second methodological contribution is a procedure developed to “quantify” the asymmetry. The approach is demonstrated and allows future research to compare asymmetric characteristics among various accuracy measures.
Toward suppliers' corporate social responsibility performance: the role of relationship dependence
Authors: Cao Zhi , Kim Dong-Young , Mu Yinping , Singhal Vinod 
Published: August 2023

PurposeThe growing focus on socially responsible supply chain management (SRSCM) has made it crucial to extend corporate social responsibility (CSR) to upstream suppliers. Drawing on resource dependence theory, this study aims to examine how supplier dependence upon socially responsible buyers impacts suppliers' CSR performance and how this relationship is moderated by network prominence and demand uncertainty.Design/methodology/approachThe proposed hypotheses are tested using regression analysis with Heckman's two-stage model and a dyadic supply chain dataset constructed based on publicly traded Chinese firms between 2008 and 2016. This time window is selected due to a one-year lag of the dependent variable and the change in evaluation methods of the database providing CSR performance in 2018.FindingsThe empirical results indicate that supplier dependence upon socially responsible buyers is positively associated with suppliers' CSR performance. However, this positive relationship is attenuated when suppliers occupy a prominent position in the network or when they face high demand uncertainty.Originality/valueThis study extends knowledge about the role of relationship dependence in implementing SRSCM by highlighting its positive impact on suppliers' CSR. Thus, this study contributes to the buyer–supplier relationship literature and the power and relationship dependence literature. This study further advances the understanding of the factors that influence suppliers' behavior by exploring the moderating roles of network prominence and demand uncertainty. The results have several practical implications for managers and policymakers.
It is a balancing act: understanding the key audit matters disclosure in the context of a developing country
Authors: Bepari Md. Khokan , Nahar Shamsun , Azim Mohammad Istiaq , Mollik Abu Taher 
Published: August 2023

Purpose
This study aims to examine the strategies that auditors in Bangladesh follow in identifying and reporting key audit matters (KAMs). The study also examines the factors affecting auditors’ strategies in the identification and disclosures of KAMs.

Design/methodology/approach
The authors have conducted interviews with audit partners, chief financial officers (CFOs) and regulators involved in KAMs reporting and monitoring. The authors have used the lens of institutional theory of coercive, mimetic and normative isomorphism and the concept of decoupling.

Findings
Auditors have used a decoupling strategy by identifying and reporting greater number of industry-generic KAMs than that of other countries in an effort to minimize risks and avoid regulatory scrutiny, although they disclose remote risks as KAMs and mask severe problem areas of the client. Because of the principle-based approach of International Standards on Auditing (ISA) 701 and because of the pressure and misunderstanding from the audit committee, auditors report industry-generic items and generic descriptions of KAMs.

Practical implications
The findings have important implications for the standard setters and local and global audit firms for the diffusion of new auditing standards in different jurisdictions. Without the development of audit firm-level capability and the corporate governance environment, changes in standards may not be effective in achieving the objectives of the standards.

Social implications
Although auditors consider that the KAMs reporting requirements provide with opportunities to enhance audit profession’s legitimacy and public trusts, the actual KAMs reporting practices are driven by the market logic, an urge to maintain the status quo with clients and eventual rationalization of the impairment of professional independence.

Originality/value
Given the dearth of prior research on the implementation and diffusion patterns of ISA 701 KAMs reporting, this study fills the gap in the literature. To the best of the authors’ knowledge, this is the first known study to examine auditors’ strategic responses to balance among conflicting priorities in reporting KAMs.
Carbon talk: comparing top brands’ climate change objectives
Authors: McIlvaine Valerie , Dahlquist Steven , Lehnert Kevin 
Published: August 2023

Purpose
Climate change and carbon emissions are top of mind in all facets of society. This study aims to investigate what the world’s top brands are saying about carbon emissions and greenhouse gases (GHG). Through this inquiry, the authors hope to better understand what brands are saying, doing and if their actions are clear. Furthermore, the authors seek to uncover practices that may deter or enhance a brand’s effectiveness in communicating its current and future initiatives.

Design/methodology/approach
Each of the world’s top 50 brands’ (Forbes, 2020 Rankings) websites were assessed using a content analysis methodology. Key constructs and themes were identified first through a broad assessment, leading to a set of parameters (content items) that were used to assess each brand’s website. The results were then summarized.

Findings
Almost all of the world’s Top 50 brands attempt to articulate their current accomplishments and goals relative to carbon emissions and GHG. Generally, carbon falls under a broader discussion of their sustainability initiatives and objectives. While extensive, information on carbon emissions possesses a variety of terms for measures and initiatives, goal setting and actions. Stakeholders may find the information to be ambiguous and of limited use.

Originality/value
There are few, if any, assessments of how major brands communicate their current and future carbon emissions initiatives. The study uncovers tendencies and provides managers with practices that may enhance the effectiveness of their brand’s carbon emissions communications.
Profound barriers to value management adoption on construction projects in a developing nation
Authors: Ojo Lekan Damilola , Ogunsemi Deji Rufus , Elyamany Ahmed , Oke Ayodeji Emmanuel 
Published: August 2023

Purpose
The adoption of value management (VM) has been on the rise in the construction industry, especially in the past decade. Identifying the main barriers to VM application for ameliorating poor project outcomes in the construction industry is a critical step to overcoming its implementation. Therefore, this study aims to examine the barriers to the adoption of VM in the Nigerian construction industry (NCI) and identify the critical ones for action by construction stakeholders.

Design/methodology/approach
This study used two rounds of Delphi surveys with 15 VM experts to identify the challenges to VM adoption. The Delphi team’s data from the two surveys were analysed using descriptive statistics. The mean-mode approach was used to identify ten major barriers to VM adoption based on the consensus reached during the second round of the Delphi poll. Following that, an interrater agreement analysis and a significant level analysis were performed.

Findings
Of the 17 identified barriers hindering VM adoption on construction projects in the NCI, 10 were found to be profound after statistical analyses of the data. The significant barriers include communication gap between the client and other consultants; delay in design preparation because of VM services; the pretext that VM is being practiced in the construction industry; and the wrong perception of VM by construction professionals, among others. The findings of the analysis suggested that the lack of VM adoption in the NCI was because of inadequate knowledge of VM techniques among construction professionals. Therefore, it is advised that VM training be provided for concerned stakeholders to address the lack of VM expertise among Nigerian construction professionals.

Practical implications
This study investigated the barriers to VM adoption on construction projects in the NCI with the opinions of a few construction professionals who can be regarded as VM experts. As against obtaining large survey responses from construction professionals who may not be knowledgeable in the VM process, the limited VM experts’ responses provide a valid basis for drawing inferences and making recommendations to address the paucity of VM applications in the NCI.

Originality/value
Through a Delphi survey, the critical barriers to the adoption of VM were identified, along with recommendations to help construction stakeholders overcome the challenges and enjoy the benefits of VM.
Flexural behavior of slabs made of lightweight foamed concrete with basalt powder
Authors: Al-Zubaidi Hanadi , Allouzi Rabab 
Published: August 2023

Purpose
Cement can be replaced to reduce the energy consumption and the environmental impact of cement. Also, foamed concrete can be used structurally in residential buildings to reduce weight and improve thermal insulation. To achieve these two goals, this paper aims to investigate the effect of basalt powder as a partial replacement of either cement or sand.

Design/methodology/approach
This paper investigates the effect of basalt powder as a partial replacement of either cement or sand on the mechanical properties of foamed concrete used to cast slabs. First, mechanical properties of foamed concrete are tested with and without replacement of basalt. Then, six slabs of different thicknesses and mixes are investigated. The thicknesses considered are 150- and 200-mm slabs. The three mixes used to construct these slabs are foamed concrete with no basalt powder, foamed concrete with replacement of 20% of cement by basalt powder and foamed concrete with replacement of 20% of sand by basalt powder. The flexural behavior of these slabs is investigated.

Findings
All the slabs failed in the commonly intended flexural mode. The results show that the basalt powder acted as a strong filler material in the foamed concrete mix based on mechanical properties and flexural behavior. The proposed foamed concrete slabs can be used structurally in residential buildings.

Originality/value
A natural waste material that can be used to promote energy efficiency and reduce emission is basalt. In this paper, basalt powder is suggested to be used due to its chemical composition that is similar to cement. Also, basalt powder is low in cost as it is waste, while basalt aggregate is prepared, and it is only used as filler in paved roads. Accordingly, basalt is partially used instead of cement to reduce the emission of carbon dioxide that results from the cement manufacturing. Also, it is used as a partial alternative to sand which can be considered as a new stronger source as filling material used in the production of concrete.