bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of an anti-cancer peptide M1-21 targeting transcription factor FOXM1
Authors: Cheng Haojie , Yuan Jie , Pei Chaozhu , Ouyang Min , Bu Huitong , Chen Yan , Huang Xiaoqin , Zhang Zhenwang , Yu Li , Tan Yongjun 
Published: June 2023

Abstract
Background
Transcription factor FOXM1 is a potential target for anti-cancer drug development. An interfering peptide M1-21, targeting FOXM1 and FOXM1-interacting proteins, is developed and its anti-cancer efficacy is evaluated.

Methods
FOXM1 C-terminus-binding peptides are screened by in silico protocols from the peptide library of FOXM1 (1-138aa) and confirmed by cellular experiments. The selected peptide is synthesized into its D-retro-inverso (DRI) form by fusing a TAT cell-penetrating sequence. Anti-cancer activities are evaluated in vitro and in vivo with tumor-grafted nude mice, spontaneous breast cancer mice, and wild-type metastasis-tracing mice. Anti-cancer mechanisms are analyzed. Distribution and safety profiles in mice are evaluated.

Results
With improved stability and cell inhibitory activity compared to the parent peptide, M1-21 binds to multiple regions of FOXM1 and interferes with protein-protein interactions between FOXM1 and its various known partner proteins, including PLK1, LIN9 and B-MYB of the MuvB complex, and β-catenin. Consequently, M1-21 inhibits FOXM1-related transcriptional activities and FOXM1-mediated nuclear importation of β-catenin and β-catenin transcriptional activities. M1-21 inhibits multiple types of cancer (20 µM in vitro or 30 mg/kg in vivo) by preventing proliferation, migration, and WNT signaling. Distribution and safety profiles of M1-21 are favorable (broad distribution and > 15 h stability in mice) and the tested non-severely toxic dose reaches 200 mg/kg in mice. M1-21 also has low hemolytic toxicity and immunogenicity in mice.

Conclusions
M1-21 is a promising interfering peptide targeting FOXM1 for the development of anti-cancer drugs.
Prognostic value of respiratory compliance course on mortality in COVID-19 patients with vv-ECMO
Authors: Valentin Simon , Amalric Mathieu , Granier Guillaume , Pequignot Benjamin , Guervilly Christophe , Duarte Kevin , Girerd Nicolas , Levy Bruno , Dunand Paul , Koszutski Matthieu , Roze Hadrien , Kimmoun Antoine 
Published: June 2023

Abstract
Background
COVID-19-associated acute respiratory distress syndrome (ARDS) supported by veno-venous extra-corporal membrane oxygenation (vv-ECMO) results in a high in-hospital mortality rate of more than 35%. However, after cannulation, no prognostic factor has been described to guide the management of these patients. The objective was to assess the association between static respiratory compliance over the first 10 days post-vv-ECMO implantation on 180-day mortality.

Results
In this multicentric retrospective study in three ECMO referral centers, all patients with COVID-19-associated ARDS supported by vv-ECMO were included from 03/01/2020 to 12/31/2021. Patients were ventilated with ultra-protective settings targeting a driving pressure lower than 15 cmH2O. 122 patients were included. Median age was 59 IQR (52–64), 83 (68%) were male, with a median body mass index of 33 (28–37) kg/m2. Delay between first symptoms to vv-ECMO implantation was 16 (10–21) days. Six-month death was 48%. Over the first ten days, compliance increased in 180 day survivors [from 18 (12–25) to 20 (15–27) mL/cmH2O] compared to non-survivors [from 12 (9–20) to 10 (8–14) mL/cmH2O, p interaction < 0.0001]. A time varying multivariable Cox model found age, history of chronic lung disease, compliance from day one to day ten and sweep gas flow from day one to day ten as independent factors associated with 180-day mortality.

Conclusions
In COVID-19-associated ARDS, static respiratory compliance course over the first ten days post-vv-ECMO implantation is associated with 180-day mortality. This new information may provide crucial information on the patient's prognosis for intensivists.
Unit middleware for implementation of human–machine interconnection intelligent ecology construction
Authors: Zhang Hai-jun , Chen Ying-hui , Zhuo Hankui 
Published: June 2023

AbstractGeneral speech recognition models require large capacity and strong computing power. Based on small capacity and low computing power to realize speech analysis and semantic recognition is a research area with great challenges for constructing intelligent ecology of the Internet of Things. For this purpose, we set up the unit middleware for the implementation of human–machine interconnection, namely human–machine interaction based on phonetics and semantics control for constructing intelligent ecology of the Internet of Things. First, through calculation, theoretical derivation and verification we present a kind of novel deep hybrid intelligent algorithm, which has realized speech analysis and semantic recognition. Second, it is to establish unit middleware using the embedded chip as the core on the motherboard. Third, it is to develop the important auxiliary tools writer-burner and cross-compiler. Fourth, it is to prune procedures and system, download, burn and write the algorithms and codes into the unit middleware and cross-compile. Fifth, it is to expand the functions of the motherboard, provide more components and interfaces, for example including RFID(Radio Frequency Identification, RFID), ZigBee, Wi-Fi, GPRS(General Packet Radio Services, GPRS), RS-232 serial port, USB(Universal Serial Bus, USB) interfaces and so on. Sixth, we take advantage of algorithms, software and hardware to make machines "understand" human speech and "think" and "comprehend" human intentions so as to implement human–machine interconnection, which further structure the intelligent ecology of the Internet of Things. At last, the experimental results denote that the unit middleware have very good effect, fast recognition speed, high accuracy and good stability, consequently realizing the intelligent ecology construction of the Internet of Things.
Robotic resection of ectopic mediastinal parathyroid adenoma in multiple endocrine neoplasia 1
Authors: Ohara Yuko , Kadomatsu Yuka , Kikumori Toyone , Chen-Yoshikawa Toyofumi F. 
Published: June 2023

Abstract
Background
Hyperparathyroidism in patients with multiple endocrine neoplasia 1 is attributed to the excessive secretion of parathyroid hormone (PTH) from multiple parathyroid glands. This can be successfully treated through complete resection of the parathyroid glands; however, subsequent surgery is often required because of the presence of supernumerary or ectopic parathyroid glands. Therefore, identifying the locations of all functional glands is crucial for precise resection. Here, we report a case of ectopic mediastinal parathyroid adenoma that was successfully resected using robot-assisted thoracoscopic surgery.

Case presentation
A 53-year-old woman underwent a total parathyroidectomy with autotransplantation for multiple endocrine neoplasia 1-associated primary hyperparathyroidism. The patient previously underwent laparoscopic distal pancreatectomy for a pancreatic neuroendocrine tumor. She also presented with a mediastinal tumor and nonfunctional pituitary adenoma that could be followed up. Blood tests before total parathyroidectomy showed high levels of intact PTH (183 pg/mL) and calcium (Ca; 10.3 mg/dL); however, postoperative blood tests still revealed high levels of intact PTH (103 pg/mL) and Ca (11.4 mg/dL). Computed tomography and magnetic resonance imaging revealed a 45-mm-sized mass in the right upper mediastinum as a well-defined solid and cystic lesion, whereas 99mTc-methoxyisobutylisonitrile scintigraphy indicated a strong accumulation of tracers, suggesting an ectopic lesion in the mediastinum. Persistent hyperparathyroidism after total parathyroidectomy via neck incision was attributed to an ectopic parathyroid tumor in the mediastinum. Thus, we decided to resect the tumor using robot-assisted thoracoscopic surgery to perform the procedure gently and carefully. During surgery, a mediastinal tumor was identified as it was detected radiographically. Because it did not invade the surrounding tissues, it could be completely resected without injuring the capsule. The patient was discharged without complications. Postoperatively, Ca and intact PTH levels decreased back to normal. The final pathological diagnosis confirmed that the mass was an ectopic mediastinal parathyroid adenoma.

Conclusions
Minimally invasive surgical resection of a remnant ectopic lesion was successfully performed in a patient with multiple endocrine neoplasia 1 using robot-assisted thoracoscopic surgery.
Gender differences in obstructive sleep apnea with comorbid treatment-resistant depression
Authors: Kasurak Emily , Hawken Emily , Kolar Dusan , Jokic Ruzica 
Published: June 2023

Abstract
Background
A bidirectional relationship between major depression and obstructive sleep apnea (OSA) has been established, suggesting the possibility of overlapping and compounding disease processes. Depression, however, while more prevalent in women, is a highly heterogeneous disorder and can be difficult to treat regardless of gender. A common overlapping symptom of depression and OSA is fatigue. Gender differences in OSA symptomatology (and fatigue in particular) are also consistently observed. Here, we investigate OSA in specific relation to treatment-resistant depression.

Methods
A cross-sectional exploratory design was used to analyse data from 94 patients with treatment-resistant depression from a subspecialist mood disorders outpatient service who had no previous sleep assessment. Participants completed overnight polysomnography and a battery of rating scales assessing mood, sleep, and daytime functioning. Linear regression models determined whether presence of fatigue in treatment-resistant depression predicted OSA severity.

Results
There was a high prevalence (79%) of previously undiagnosed OSA in our sample of patients with treatment-resistant depression. Treatment-resistant depression was one factor to close the gap in obstructive sleep apnea prevalence between men and women in this group. Presence of OSA measured objectively by the Apnea Hypopnea Index was not associated with episode state (depressed vs. euthymic). Daytime sleepiness scores as measured by the Epworth Sleepiness Scale indicated higher than normal daytime sleepiness with no difference between genders. Men and women in our study reported similar amounts of fatigue as measured by the Profile of Mood States-Fatigue Subscale, however, daytime fatigue (but not sleepiness) predicted OSA severity in women only.

Conclusions
We argue that typical symptoms of treatment-resistant depression may overshadow key symptoms of undetected OSA. Specifically, we found that daytime fatigue may be one factor masking a potentially significant underlying sleep disorder in women only. Comprehensive assessment and screening for sleep apnea in patients with treatment-resistant depression is encouraged, and the importance of investigating severity of fatigue in this population is emphasized.
Remote collection of electrophysiological data with brain wearables: opportunities and challenges
Authors: Sugden Richard James , Pham-Kim-Nghiem-Phu Viet-Linh Luke , Campbell Ingrid , Leon Alberto , Diamandis Phedias 
Published: June 2023

AbstractCollection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to sophisticated hardware, EEG studies have been largely limited to research centers which restrict both testing contexts and repeated longitudinal measures. The emergence of low-cost “wearable” EEG devices now provides the prospect of frequent and remote monitoring of the human brain for a variety of physiological and pathological brain states. In this manuscript, we survey evidence that EEG wearables provide high-quality data and review various software used for remote data collection. We then discuss the growing body of evidence supporting the feasibility of remote and longitudinal EEG data collection using wearables including a discussion of potential biomedical applications of these protocols. Lastly, we discuss some additional challenges needed for EEG wearable research to gain further widespread adoption.
Association of Body Mass Index and Its Change With Incident Diabetes Mellitus
Authors: Ohno Ryusei , Kaneko Hidehiro , Ueno Kensuke , Aoki Hiroyuki , Okada Akira , Kamiya Kentaro , Suzuki Yuta , Matsuoka Satoshi , Fujiu Katsuhito , Takeda Norifumi , Jo Taisuke , Ako Junya , Morita Hiroyuki , Node Koichi , Yasunaga Hideo , Komuro Issei 
Published: June 2023

Abstract

Context
There have been insufficient data on the threshold of body mass index (BMI) for developing diabetes mellitus (DM) and the relationship between change in BMI and the subsequent risk of DM.

Objective
We sought to clarify the association of BMI and its change with incident DM.

Methods
We conducted a retrospective observational cohort study using the JMDC Claims Database between 2005 and 2021. We included 3 400 303 individuals without a prior history of DM or usage of glucose-lowering medications. The median age was 44 years, and 57.5% were men. We categorized the study participants into 4 groups: underweight (BMI &lt; 18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2), and obese (BMI ≥ 30 kg/m2). According to the change in BMI from the initial health check-up to the health check-up 1 year after that, we divided the study participants into 3 groups: ≤−5.0%, −5.0% to +5.0%, and ≥+5.0%.

Results
The risk of developing DM increased steeply after BMI exceeded approximately 20 to 21 kg/m2. Compared with participants with stable BMI (−5.0% to +5.0%), the relative risk for DM among those whose BMI had increased by 5.0% or more was 1.33 (95% CI 1.31-1.36). In contrast, the relative risk for DM among those whose BMI decreased by 5.0% or more was 0.82 (95% CI 0.80-0.84). Moreover, people classified as normal weight, overweight, and obese reduced the risk of developing DM when they reduced their BMI, whereas the risk of developing DM for people classified as underweight increased when they reduced their BMI.

Conclusion
Our findings offer novel insights into improving an optimal bodyweight management strategy to prevent the development of DM.
Neurologic Complications of Endocrine Disorders
Authors: Reda Haatem 
Published: June 2023

ABSTRACT

OBJECTIVE
This article provides an overview of the neurologic complications of the most prevalent endocrine disorders in adults with an emphasis on relevant neurologic symptoms, signs, and laboratory and neuroimaging findings.

LATEST DEVELOPMENTS
Although the mechanisms of many of the neurologic complications discussed here remain unclear, our understanding of the impacts of diabetes and hypothyroidism on the nervous system and muscle, including complications of rapid correction of chronic hyperglycemia, has advanced in recent years. Recent large studies have not demonstrated a convincing association between subclinical or overt hypothyroidism and cognitive decline.

ESSENTIAL POINTS
Neurologists must become familiar with the neurologic complications of endocrine disorders not only because they are common and treatable (and often reversible) but also because they may be iatrogenic, as is the case with adrenal insufficiency in the setting of long-term corticosteroid therapy.
Fragments of an Indian Ocean Life: Aristide Corroller between Islands and Empires
Authors: Larson Pier M. 
Published: June 2023

Abstract
Born on Ile de France in late 1799 to a French father and a free mixed-race mother from Fort-Dauphin in southeast Madagascar, Aristide Corroller gained an education at Port-Louis but departed to pursue a political career in Madagascar after 1815. Corroller first assisted his maternal uncles to capture the sovereignty of Madagascar's central eastern coast (Ivondro-Tamatave-Foulpointe) but then entered the service of King Radama of Imerina. He rose through the ranks of Radama's service to become commander-in-chief of Antananarivo's armed forces and the second most powerful man of that independent kingdom. His fortunes soured with the death of Radama in July 1828, however. He was placed under house arrest for a time and then returned to govern Tamatave but died there with frustrated ambitions in late 1835, leaving a written account of his achievements on which this article is substantially based. This article employs Corroller's writings found in a library in New Zealand not only to trace his career but to discuss the strategies of his island-hopping family—particularly his maternal ancestors from Madagascar who moved to Ile de France and his maternal uncles who returned to Madagascar—and the careers of European administrators of empire who collected and pored over his work. Corroller's career, mixed-race family, and labors illuminate the contours of life in the western Indian Ocean islands of his time, bringing their migrations, commerce, colonial constraints and opportunities, as well as human interconnections and racial structures, into conversation.
Earlier Tracheostomy Reduces Complications in Complete Cervical Spinal Cord Injury in Real-World Practice: Analysis of a Multicenter Cohort of 2001 Patients
Authors: Balas Michael , Jaja Blessing N. R. , Harrington Erin M. , Jack Andrew S. , Hofereiter Johann , Malhotra Armaan K. , Jaffe Rachael H. , He Yingshi , Byrne James P. , Wilson Jefferson R. , Witiw Christopher D. 
Published: June 2023

BACKGROUND AND OBJECTIVES:
It is believed that early tracheostomy in patients with traumatic cervical spinal cord injury (SCI) may lessen the risk of developing complications and reduce the duration of mechanical ventilation and critical care stay. This study aims to assess whether early tracheostomy is beneficial in patients with traumatic cervical SCI.

METHODS:
We conducted a retrospective cohort study using data from the American College of Surgeons Trauma Quality Improvement Program database from 2010 to 2018. Adult patients with a diagnosis of acute complete (ASIA A) traumatic cervical SCI who underwent surgery and tracheostomy were included. Patients were stratified into those receiving early (at or before 7 days) and delayed tracheostomy. Propensity score matching was used to assess the association between delayed tracheostomy and the risk of in-hospital adverse events. Risk-adjusted variability in tracheostomy timing across trauma centers was investigated using mixed-effects regression.

RESULTS:
The study included 2001 patients from 374 North American trauma centers. The median time to tracheostomy was 9.2 days (IQR: 6.1-13.1 days), with 654 patients (32.7%) undergoing early tracheostomy. After matching, the odds of a major complication were significantly lower for early tracheostomy patients (OR: .90; 95% CI: .88-.98). Patients were also significantly less likely to experience an immobility-related complication (OR: .90; 95% CI: .88-.98). Patients in the early group spent 8.2 fewer days in the critical care unit (95% CI: −10.2 to −6.61) and 6.7 fewer days ventilated (95% CI: −9.44 to −5.23). There was significant variability in tracheostomy timeliness between trauma centers with a median odds ratio of 12.2 (95% CI: 9.7-13.7), which was not explained by case-mix and hospital-level characteristics.

CONCLUSION:
A 7-day threshold to implement tracheostomy seems to be associated with reduced in-hospital complications, time in the critical care unit, and time on mechanical ventilation.
Ventricular fold oscillations lower the vocal pitch in rhesus macaques
Authors: Miyazaki Rintaro , Yoshitani Tomoki , Kanaya Mayuka , Miyachi Shigehiro , Kaneko Akihisa , Kinoshita Yuki , Nakamura Kanta , Nishimura Takeshi , Tokuda Isao T. 
Published: June 2023

ABSTRACT
We carried out ex vivo and in vivo experiments to explore the functional role of the ventricular folds in sound production in macaques. In the ex vivo experiments, 29 recordings out of 67 showed that the ventricular folds co-oscillated with the vocal folds. Transitions from normal vocal fold oscillations to vocal–ventricular fold co-oscillations as well as chaotic irregular oscillations were also observed. The in vivo experiments indicated that the vocal–ventricular fold co-oscillations were also observed in two macaque individuals. In both ex vivo and in vivo experiments, the vocal–ventricular fold co-oscillations significantly lowered the fundamental frequency. A mathematical model revealed that the lowering of the fundamental frequency was caused by a low oscillation frequency inherent in the ventricular folds, which entrained the vocal folds to their low-frequency oscillations. From a physiological standpoint, the macaques may utilize the ventricular fold oscillations more frequently than humans. The advantages as well as disadvantages of using the ventricular folds as an additional vocal repertory are discussed.
Qualitative interviews to understand methods and systems used to collect ethnicity information in health administrative data sources in England
Authors: Quayle Gemma , Jones Bethan , Atkins Jessica , Shannon Caitriona , Smith Roxanne , Tabor David , Bałabuch Zuzanna , Cox Courtney , Horsell Sarah , John Marie , McGrail White Tomas , Vickers Sophie , Whittinger Sophia , Bannister Neil , Raleigh Veena , Mateen Bilal , Drummond Rosemary 
Published: June 2023

Background: This article is one of a series aiming to inform analytical methods to improve comparability of estimates of ethnic health disparities based on different sources. This article explores the quality of ethnicity data and identifies potential sources of bias when ethnicity information is collected in three key NHS data sources. Future research can build on these findings to explore analytical methods to mitigate biases. Methods: Thematic analysis of semi-structured qualitative interviews to explore potential sources of error and bias in the process of collecting ethnicity information across three NHS data sources: General Practice Extraction Service (GPES) Data for Pandemic Planning and Research (GDPPR), Hospital Episode Statistics (HES) and Improving Access to Psychological Therapies (IAPT). The study included feedback from 22 experts working on different aspects of health admin data collection for England (including staff from NHS Digital, IT system suppliers and relevant healthcare service providers). Results: Potential sources of error and bias were identified across data collection, data processing and quality assurance processes. Similar issues were identified for all three sources. Our analysis revealed three main themes which can result in bias and inaccuracies in ethnicity data recorded: data infrastructure challenges, human challenges, and institutional challenges. Conclusions: Findings highlighted that analysts using health admin data should be aware of the main sources of potential error and bias in health admin data, and be mindful that the main sources of error identified are more likely to affect the ethnicity data for ethnic minority groups. Where possible, analysts should describe and seek to account for this bias in their research.