bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta-analysis of the efficacy of Roux-en-Y anastomosis and jejunal interposition after total gastrectomy
Authors: Liu Yu-hang , Meng Rui , Zhu Bing , Zhan Qi-qi , Yang Xin , Ding Guan-yi , Jia Chun-liang , Xu Wei-guo 
Published: April 2023

Abstract

Background
To compare the clinical efficacy of two alimentary tract reconstruction methods—“P”-shape jejunal interposition (PJI) and Roux-en-Y anastomosis after total gastrectomy.

Method
The following search phrases were utilized to search PubMed, Cochrane Library, Embase, China Academic Journals Network Full-text Database (CNKI), and Wanfang Database as of April 2022: “gastrectomy,” “Roux-en-Y,” “interposition,” “total gastrectomy,” and “jejunal interposition.” Meta-analysis of the operation time, intraoperative blood loss, complication rate, and postoperative nutritional status of patients was performed using RevMan 5.4 software.

Results
A total of 24 studies and 1887 patients were included in the study. Among patients who received a total gastrectomy, the operation time in the PJI group was substantially longer than that in the Roux-en-Y group (WMD = 19.77, 95% CI: 5.84–33.70, P = 0.005). The incidence of postoperative reflux esophagitis in the PJI group was considerably reduced than that in the Roux-en-Y group (OR = 0.39, 95% CI: 0.28–0.56, P < 0.01). The probability of postoperative dumping syndrome in the PJI group was significantly lower than that in the Roux-en-Y group (OR = 0.27, 95% CI: 0.17–0.43, P < 0.01), and the postoperative body mass changes were significantly lower in the PJI group than in the Roux-en-Y group (WMD = 3.94, 95% CI: 2.24–5.64, P < 0.01). The PJI group had substantially higher postoperative hemoglobin, albumin, and total protein levels than the Roux-en-Y group (WMD = 13.94, 95% CI: 7.77–19.20, P < 0.01; WMD = 3.97, 95% CI: 2.58–5.37, P < 0.01; WMD = 5.31, 95% CI: 3.45–7.16, P < 0.01). The prognostic nutritional index was higher in the PJI group than in the Roux-en-Y group (WMD = 9.25, 95% CI: 7.37–11.13, P < 0.01).

Conclusion
PJI is a safe and effective reconstruction method and is superior to Roux-en-Y anastomosis in the prevention and treatment of postoperative complications and postoperative nutritional recovery in patients after total gastrectomy.
Del-Nido cardioplegia in cardiac surgery for elderly patients: a propensity score-matched analysis
Authors: Gu Wenda , Qing Hongkun , Luo Xiang , Zang Xin , Zhou Kan , Guo Haijiang , Zhou Chengbin , Guo Huiming , Liu Jian 
Published: April 2023

AbstractObjectivesTo compare the safety and efficacy of del-Nido cardioplegia (DNC) with traditional 4:1 cold blood cardioplegia (CBC) in coronary artery bypass grafting and/or valve surgeries in elderly patients.MethodsThe present study is a retrospective case-series study that included 302 consecutive patients aged 70 years and over who underwent on-pump valve surgery and/or coronary artery bypass graft (CABG). DNC was administered to 90 patients and CBC to 212 patients. After propensity-score matching, 89 pairs were compared. The safety and efficacy were analyzed between the two groups.ResultsThe DNC group had a similar mortality (3.4% vs. 5.6%, OR = 0.79,P = 0.720) and extracorporeal membrane oxygenation (ECMO) implantation rate (1.1% vs. 2.2%, OR = 0.75,P = 1.000) to the CBC group, a lower incidence of postoperative intra-aortic balloon pump (IABP) implantation (1.1% vs. 9.0%, OR = 0.54,P = 0.034) and a higher left ventricular ejection fraction (LVEF) at discharge (60 (56–64) % vs. 57 (51–62)%,P = 0.007). The estimated glomerular filtration rate (eGFR) in the DNC group was higher when the patient was transferred to the intensive care unit (79.4 (65.0-94.3) ml/min/1.73m2vs. 77.2 (59.8–88.7) ml/min/1.73m2,P = 0.014), but no significant differences were identified after 24 h. The serum lactate values of the DNC group were significantly lower than those of the CBC group (0 h: 2.7 (2.0-3.2) vs. 3.2 (2.4–4.4),P = 0.001; 3 h: 3.2 (2.0-4.8) vs. 4.8 (2.8–6.6),P < 0.001; 6 h: 3.5 (2.2–5.4) vs. 5.8 (3.4–8.4),P < 0.001; 9 h: 3.4 (2.0–7.0) vs. 5.5 (2.9–8.3),P = 0.005). There were no differences between the two groups in respect of lactate levels at 12 h and thereafter. Postoperative creatinine kinase-MB concentrations were similar between the two groups.ConclusionsDel-Nido cardioplegia is safe and effective in elderly patients undergoing CABG and/or valve surgery.
High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma
Authors: Lang Martin , Schmidt Laura S. , Wilson Kelli M. , Ricketts Christopher J. , Sourbier Carole , Vocke Cathy D. , Wei Darmood , Crooks Daniel R. , Yang Youfeng , Gibbs Benjamin K. , Zhang Xiaohu , Klumpp-Thomas Carleen , Chen Lu , Guha Rajarshi , Ferrer Marc , McKnight Crystal , Itkin Zina , Wangsa Darawalee , Wangsa Danny , James Amy , Difilippantonio Simone , Karim Baktir , Morís Francisco , Ried Thomas , Merino Maria J. , Srinivasan Ramaprasad , Thomas Craig J. , Linehan W. Marston 
Published: April 2023

Abstract
Background
MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC that is predominantly seen in young patients and can present with heterogeneous histological features making diagnosis challenging. Moreover, the disease biology of this aggressive cancer is poorly understood and there is no accepted standard of care therapy for patients with advanced disease. Tumor-derived cell lines have been established from human TFE3-RCC providing useful models for preclinical studies.

Methods
TFE3-RCC tumor derived cell lines and their tissues of origin were characterized by IHC and gene expression analyses. An unbiased high-throughput drug screen was performed to identify novel therapeutic agents for treatment of MiT-RCC. Potential therapeutic candidates were validated in in vitro and in vivo preclinical studies. Mechanistic assays were conducted to confirm the on-target effects of drugs.

Results
The results of a high-throughput small molecule drug screen utilizing three TFE3-RCC tumor-derived cell lines identified five classes of agents with potential pharmacological efficacy, including inhibitors of phosphoinositide-3-kinase (PI3K) and mechanistic target of rapamycin (mTOR), and several additional agents, including the transcription inhibitor Mithramycin A. Upregulation of the cell surface marker GPNMB, a specific MiT transcriptional target, was confirmed in TFE3-RCC and evaluated as a therapeutic target using the GPNMB-targeted antibody-drug conjugate CDX-011. In vitro and in vivo preclinical studies demonstrated efficacy of the PI3K/mTOR inhibitor NVP-BGT226, Mithramycin A, and CDX-011 as potential therapeutic options for treating advanced MiT-RCC as single agents or in combination.

Conclusions
The results of the high-throughput drug screen and validation studies in TFE3-RCC tumor-derived cell lines have provided in vitro and in vivo preclinical data supporting the efficacy of the PI3K/mTOR inhibitor NVP-BGT226, the transcription inhibitor Mithramycin A, and GPNMB-targeted antibody-drug conjugate CDX-011 as potential therapeutic options for treating advanced MiT-RCC. The findings presented here should provide the basis for designing future clinical trials for patients with MiT-driven RCC.
Upper body posture in Latin American dancers: a quantitative cross-sectional study comparing different postures
Authors: Wanke Eileen M. , Mörl-Kreitschmann Manja , Holzgreve Fabian , Groneberg David , Ohlendorf Daniela 
Published: April 2023

Abstract
Background
In Latin American dance sport (LD), the shoulder girdle and the torso area are particularly stressed due to the dance style specific requirements. The aim of the study was to define differences in various dance specific upper body postures in Latin American dancers and to show gender-specific differences.

Methods
Three dimensional back scans were performed in n = 49 dancers (28 f/21 m). Five typical trunk positions in Latin American dance (habitual standing and 4 dance specific positions, P1–P5) were compared with each other. Statistical differences were calculated using the Man-Whitney U test, Friedmann test, Conover-Iman test and a Bonferroni-Holm correction.

Results
Significant gender differences were found in P2, P3 and P4 (p ≤ 0.01–0.001). In P5, the frontal trunk decline, the axis deviation, the standard deviation of the rotation, the kyphosis angle and the shoulder as well as the pelvic rotation were also significantly different. The comparison of the postures showed significant differences between postures 1–5 (p ≤ 0.01–0.001) in the males, (scapular height, right and left scapular angles and pelvic torsion). Similar results were observed for the female dancers, with only the parameters of frontal trunk decline with the lordosis angle as well as the right and left scapular angles being non-significant.

Conclusions
This study is an approach to better understand the involved muscular structures in LD. Performing LD changes the static parameters of the upper body statics. Further projects are needed to analyse the field of dance even more thoroughly.
Identification of four novel large deletions and complex variants in the α-globin locus in Chinese population
Authors: Bao Xiuqin , Wang Jicheng , Qin Danqing , Yao Cuize , Liang Jie , Liang Kailing , Zeng Yukun , Du Li 
Published: April 2023

Abstract
Background
At present, the methods generally used to detect α-thalassemia mutations are confined to detecting common mutations, which may lead to misdiagnosis or missed diagnosis. The single-molecule real-time (SMRT) sequencing enables long-read single-molecule sequencing with high detection accuracy, and long-length DNA chain reads in high-fidelity read mode. This study aimed to identify novel large deletions and complex variants in the α-globin locus in Chinese population.

Methods
We used SMRT sequencing to detect rare and complex variants in the α-globin locus in four individuals whose hematological data indicated microcytic hypochromic anemia. However, the conventional thalassemia detection result was negative. Multiplex ligation-dependent probe amplification and droplet digital polymerase chain reaction were used to confirm SMRT sequencing results.

Results
Four novel large deletions were observed ranging from 23 to 81 kb in the α-globin locus. One patient also had a duplication of upstream of HBZ in the deletional region, while another, with a 27.31-kb deletion on chromosome 16 (hg 38), had abnormal hemoglobin Siriraj (Hb Siriraj).

Conclusion
We first identified the four novel deletions in the α-globin locus using SMRT sequencing. Considering that the conventional methods might lead to misdiagnosis or missed diagnosis, SMRT sequencing proved to be an excellent method to discover rare and complex variants in thalassemia, especially in prenatal diagnosis.
Prevalence and risk distribution of schistosomiasis among adults in Madagascar: a cross-sectional study
Authors: Gruninger Sarah Katharina , Rasamoelina Tahinamandranto , Rakotoarivelo Rivo Andry , Razafindrakoto Anjarasoa Ravo , Rasolojaona Zaraniaina Tahiry , Rakotozafy Rodson Morin , Soloniaina Patrick Richard , Rakotozandrindrainy Njary , Rausche Pia , Doumbia Cheick Oumar , Jaeger Anna , Zerbo Alexandre , von Thien Heidrun , Klein Philipp , van Dam Govert , Tannich Egbert , Schwarz Norbert Georg , Lorenz Eva , May Jürgen , Rakotozandrindrainy Raphael , Fusco Daniela 
Published: April 2023

Abstract
Background
The goal to eliminate the parasitic disease of poverty schistosomiasis as a public health problem is aligned with the 2030 United Nations agenda for sustainable development goals, including universal health coverage (UHC). Current control strategies focus on school-aged children, systematically neglecting adults. We aimed at providing evidence for the need of shifting the paradigm of schistosomiasis control programs from targeted to generalized approaches as key element for both the elimination of schistosomiasis as a public health problem and the promotion of UHC.

Methods
In a cross-sectional study performed between March 2020 and January 2021 at three primary health care centers in Andina, Tsiroanomandidy and Ankazomborona in Madagascar, we determined prevalence and risk factors for schistosomiasis by a semi-quantitative PCR assay from specimens collected from 1482 adult participants. Univariable and multivariable logistic regression were performed to evaluate odd ratios.

Results
The highest prevalence of S. mansoni, S. haematobium and co-infection of both species was 59.5%, 61.3% and 3.3%, in Andina and Ankazomborona respectively. Higher prevalence was observed among males (52.4%) and main contributors to the family income (68.1%). Not working as a farmer and higher age were found to be protective factors for infection.

Conclusions
Our findings provide evidence that adults are a high-risk group for schistosomiasis. Our data suggests that, for ensuring basic health as a human right, current public health strategies for schistosomiasis prevention and control need to be re-addressed towards more context specific, holistic and integrated approaches.
The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia
Authors: O'Connor David , Demeulemeester Jonas , Conde Lucia , Kirkwood Amy , Fung Kent , Papaleonidopoulou Foteini , Bloye Gianna , Farah Nadine , Rahman Sunniyat , Hancock Jeremy , Bateman Caroline , Inglott Sarah , Mee Jon , Herrero Javier , Van Loo Peter , Moorman Anthony V. , Vora Ajay , Mansour Marc R. 
Published: April 2023

PURPOSE Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF). METHODS We studied all cases of T-ALL IF on two consecutive multinational randomized trials, UKALL2003 and UKALL2011, to define risk factors, treatment, and outcomes. We performed multiomic profiling to characterize the genomic landscape. RESULTS IF occurred in 10.3% of cases and was significantly associated with increasing age, occurring in 20% of patients age 16 years and older. Five-year overall survival (OS) rates were 52.1% in IF and 90.2% in responsive patients ( P < .001). Despite increased use of nelarabine-based chemotherapy consolidated by hematopoietic stem-cell transplant in UKALL2011, there was no improvement in outcome. Persistent end-of-consolidation molecular residual disease resulted in a significantly worse outcome (5-year OS, 14.3% v 68.5%; HR, 4.10; 95% CI, 1.35 to 12.45; P = .0071). Genomic profiling revealed a heterogeneous picture with 25 different initiating lesions converging on 10 subtype-defining genes. There was a remarkable abundance of TAL1 noncoding lesions, associated with a dismal outcome (5-year OS, 12.5%). Combining TAL1 lesions with mutations in the MYC and RAS pathways produces a genetic stratifier that identifies patients highly likely to fail conventional therapy (5-year OS, 23.1% v 86.4%; HR, 6.84; 95% CI, 2.78 to 16.78; P < .0001) and who should therefore be considered for experimental agents. CONCLUSION The outcome of IF in T-ALL remains poor with current therapy. The lack of a unifying genetic driver suggests alternative approaches, particularly using immunotherapy, are urgently needed.
Effects of Mine Water Irrigation on Soil Salinity and Winter Wheat Growth
Authors: Huang Zhixi , Ma baoguo , Wang jian , Liu liang , Zhao ying , Xi zengfu , Qi shuanwang , Song shihao , guan ronghao 
Published: April 2023

HighlightsMine water irrigation can promote the plant height growth of winter wheat, but inhibit the growth of leaf area.High salinity mine water irrigation will inhibit the growth and development of winter wheat and reduce the yield.Mixed irrigation of mine water and clean water (the ratio is 1:1) is beneficial to the growth of winter wheat.Short-term mine water irrigation will not cause soil salinization.Abstract. There is a serious shortage of irrigation water in the overlapped areas of crop and mineral production in North China. The key to solve the problem is to utilize mine water safely and efficiently. The effects of mine water irrigation (MI), mixed mine water and clean water irrigation (MIMC), rotational mine water and clean water irrigation, irrigated with mine water first, then clean water (RIMC) and clean water irrigation (CK) on winter wheat growth and soil salinity were studied through two years of field trials (2012 to 2014). The results showed that different models of mine water irrigation had no difference in plant height, but had obvious inhibitory effect on leaf area of wheat. Compared with CK, MI increased plant height by 1.0% to 3.4%, and leaf area was 69.5% to 81.9% of that of CK. Compared with CK, the yield of MIMC was increased by 2.6% to 6.67%, and the yield of RIMC and MI was decreased by 3.4% to 21.1% and 10.4% to 11.2%, respectively. The MI with high salinity could inhibit the growth and development of winter wheat, and reduce the yield and quality, while the yield of MIMC was higher than that of CK, and could improve the quality of winter wheat. Long-term irrigation of using mine water with high salinity will increase the risk of soil salinization, but MIMC can improve soil fertility. Keywords: Growth, Irrigation, Mine water, Soil salinity, Winter wheat.
Dielectric Constant-Based Grain Mass Estimation Using Radio Frequencies Sensing Technology
Authors: Zhang Yu , Striker Ryan , Disu Moruf , Monono Ewumbua , Peckrul Allen , Advani Gurmukh , Chen Bingcan , Braaten Benjamin , Sun Xin 
Published: April 2023

HighlightsRadio frequency sensing technology was used to estimate clean grain mass based on grain moisture content and grain properties.Multiple variable regression analysis was used to develop grain mass estimation model.A grain mass estimation model with high R2 was developed by introducing dielectric properties and phase angle.Parameter of dielectric constant e' indicated the domination of moisture content in grain mass estimation model.Abstract. Grain mass estimation is critical in many precision agriculture applications, especially in yield monitoring during harvest procedures. A new clean grain mass estimation method using Radio Frequency (RF) sensing technology is discussed in this paper. RF sensing technology is sensitive to moisture content and grain properties. In this study, a vector network analyzer (VNA) and a pair of horn antennas were used to collect phase shift and attenuation data from 1 to 18 GHz of grain samples (soybean, canola, and corn) on a static testbed in an anechoic chamber. Using multiple variable linear regression analysis, a comprehensive clean grain mass estimation model was developed based on the dielectric properties of the grain samples derived from the S-Parameters at 13 GHz. Dielectric (e') constant/properties and phase shift were introduced into the regression models and generated a grain mass estimation result with R2 values of 0.976, 0.977, and 0.989 for soybean, canola, and corn samples, respectively. The results indicate that RF sensing technology can reveal how grain attributes interact with electromagnetic fields at a certain frequency and has the potential to provide more accurate sensing methods for estimating grain mass in multiple precision agricultural applications. Keywords: Keywords., Dielectric properties, Grain mass estimation, Microwave frequency, Phase shifts, Radio frequency sensing.
Research on Automatic Driving Control of Tracked Transport Vehicle Based on Labview
Authors: Yu Yao , Li Yunwu , Chen Yuyi , Zhao Ying 
Published: April 2023

HighlightsAn indirect Kalman filter algorithm is proposed to fuse GNSS/INS positioning information.Detailed kinematics and dynamics model of track vehicles was established.An MPC-based double-layer closed-loop controller combined with tracked vehicle model is designed.Tracked transport vehicle performs well in path tracking on soft soil road.Abstract. Orchards in hills and mountainous regions are more occluded and single satellite navigation is unstable. Therefore, the indirect Kalman filter information fusion algorithm was proposed to achieve high-precision positioning by establishing a state error equation based on GNSS/INS. A complete kinematics and dynamics model of tracked chassis was established. A double-layer closed-loop controller based on model predictive control (MPC) was designed. An MPC controller based on the kinematics model in the outer loop was designed to output the expected control value of the tracked transporter. The inner loop design was based on the extended state observer of the dynamic model to estimate and compensate for the internal and external disturbances of the system. The performance test was based on a tracked chassis platform. The test results presented that when driving at a speed of 0.50 m/s under soft soil road conditions, the maximum lateral deviation was 0.15 m, and the average absolute deviation was 0.05 m. This high level of control accuracy means that this control design enables the transfer vehicle to follow the navigation path precisely and complete its task. Keywords: Hills and mountainous regions, Integrated navigation, Model predictive control, Vehicle dynamics model.
Computer Vision Approach for Tile Drain Outflow Rate Estimation
Authors: Young Sierra N , Han Meng , Peschel Joshua M 
Published: April 2023

HighlightsVision-based approach for detecting outlet flow of tile drains in a laboratory environment.Method accurately detects and estimates flow within 12% or less of ground truth flow rate.A real-time application was developed that provides estimated flow rates from collected video.Abstract. This article presents a computer vision-based approach for monitoring water flow at outlet points of a tile drain system. The approach relies only on video capture of events at outlet points, thus a camera can be installed remotely and without contact with water. The algorithm detects, identifies, and tracks flows by motion, shape, and color features and measures flow rate based on a proposed model and two provided dimensions. The software was tested in a laboratory environment with three different target flow rate conditions: 0.312, 0.946, and 1.58 L/s (5, 15, and 25 gal/min). Flow rates reported by the computer vision approach are within 12% of the ground-truth flow rate baseline. The results of this work show that computer vision can be used as a reliable method for monitoring outlet flows from free-standing outlet structures under laboratory conditions. This work opens the possibility of applying computer vision techniques in tile drain monitoring from outlet points with mobile video recording devices in the field. Keywords: Keywords., Morphological transformations, Outflow detection, Outlet flow, Real-time application.