bluuebunny/crossref_metadata_2025_split huggingface dataset:
The never-ending patient journey of chronically ill patients: A qualitative case study on touchpoints in relation to patient-centered care
Authors: Maas Vera K. , Dibbets Frederik H. , Peters Vincent J. T. , Meijboom Bert R. , van Bijnen Daniëlle 
Published: May 2023

Background
Healthcare professionals caring for chronically ill patients increasingly want to provide patient-centered care (PCC). By understanding each individual patient journey, they can significantly improve the quality of PCC. A patient journey consists of patient interactions, so-called touchpoints, with healthcare professionals distributed over three periods: pre-service, service, and post-service period. The aim of this study was to ascertain chronically ill patients’ needs for digital alternatives for touchpoints. Specifically, we aimed to explore which digital alternatives patients would like to see implemented into their patient journey to help healthcare professionals providing PCC.

Methods
Eight semi-structured interviews were conducted either face-to-face or via Zoom. Participants were included if they had visited the department of internal medicine and had received treatment for either arteriosclerosis, diabetes, HIV, or kidney failure. The interviews were analyzed utilizing a thematic analysis approach.

Results
The results suggest that the patient journey of chronically ill patients is a continuous cycle. Furthermore, the results showed that chronically ill patients would like to see digital alternatives for touchpoints implemented into their patient journey. These digital alternatives consisted of video calls, digitally checking in before a physical appointment, digitally self-monitoring one’s medical condition and personally uploading monitoring results into the patient portal, and viewing their own medical status in a digital format. Particularly, patients who were familiar with their healthcare professional(s) and were in a stable condition mostly opted for digital alternatives.

Conclusion
In the cyclical patient journey, digitalization can help put the wishes and needs of the chronically ill patients at the center of care. It is recommended that healthcare professionals implement digital alternatives for touchpoints. Most chronically ill patients consider digital alternatives to lead to more efficient interactions with their healthcare professionals. Furthermore, digital alternatives support patients to be better informed about the progress of their chronical illness.
EXTRACTION OF POLYPHENOLIC COMPOUNDS FROM THE JUGLANS REGIA L. PELLICLES OF USING ULTRASOUND
Authors: Bazarnova Julia , Chernikova Daria , Sevastyanova Anna , Đurović Saša 
Published: May 2023

The attention of Russian and foreign scientists is focused on obtaining secondary plant metabolites, including phenolic compounds, due to their pharmacological activity. The Juglans regia L. pellicles are a promising raw source for the production of alkaloids, naphthoquinones (juglone), tannins and organic acids. In modern practice of obtaining biologically active substances from plant raw materials, intensive extraction methods are of particular interest. In this extraction method ultrasonic treatment is used to increase the yield and intensify the process of extracting biologically significant substances. Technological parameters of ultrasonic treatment must be selected individually for each type of plant raw material. The aim of the work was to study the effect of ultrasonic treatment on the yield of polyphenolic substances during extraction from the pellicles of breeding varieties Juglans regia L. It was found that the content of tannins in the pellicle biomass of the studied varieties Juglans regia L. varies from 5.2 to 7.3 g/100 g, phenolic compounds – from 17 to 18.2 mg/100 g. The highest content of these compounds was recorded in the pellicle biomass of the Valentina's Gift variety. It was found that ultrasonic treatment with a power of 200 W for 10 min contributes to the highest yield of polyphenolic substances in the extract from the pellicle biomass of the Valentina's Gift variety. However, the spectral profiles of hydroalcoholic extracts indicate the opposite: 200 W ultrasound reduces the intensity of the extraction of polyphenolic compounds.
Modern glucose-lowering treatment effect on bone remodeling in experimental diabetes mellitus and surgical menopause
Authors: Тimkina N. V. , Semenova N. Yu. , Simanenkova A. V. , Zinserling V. A. , Vlasov T. D. , Bairamov А. A. , Khalzova A. K. , Shimshilashvili A. A. , Тimofeeva V. A. , Karonova T. L. 
Published: May 2023

BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for low-traumatic fractures. On the other hand, hypoglycemic drugs can have both positive and negative effects on bone remodeling.THE AIM: Тo investigate bone metabolism parameters during surgical menopause and experimental DM under the treatment with glucagon-like peptide receptor agonist type 1 (arGLP-1) liraglutide (LIRA) and sodium-glucose cotransporter type 2 inhibitor (iSGLT-2) canagliflozin (CANA).MATERIALS AND METHODS: Female Wistar rats have been subjected to bilateral ovariectomy at the beginning of the experiment. Diabetes mellitus (DM) was modelled using a high-fat diet and streptozotocin+nicotinamide. Four weeks after the following groups were formed: “OE+DM” (females after ovariectomy with DM and without any therapy, n=4) «OE+DM+CANA» (females after ovariectomy with DM under treatment with CANA, n=4), «OE+DM+LIRA» (females after ovariectomy with DM under treatment LIRA, n=5). The treatment or observation period were continuing for 8 weeks. Calcium, phosphorus and bone turnover markers (fibroblast growth factor-23 (FGF-23), osteocalcin, sclerostin, osteoprotegerin (OPG), nuclear factor-kappa-B receptor activator ligand (RANKL), were measured in the end of experiment. Bone histomorphometry was performed after euthanasia.RESULTS: Treatment with both CANA and LIRA did not significantly affect the phosphorus-calcium metabolism, sclerostin and osteocalcin concentrations. At the same time, the level of OPG was the highest in «OE+DM ‘’ group (9.1 [7.81; 10.045] pmol/l). The differences were significant compared with «OE+DM+CANA’’ (2, 33 [1.84; 5.84] pmol/l, p = 0.003) and «OE+DM+LIRA» (1.7 [1; 2] pmol/l, p = 0.003) groups. There were no differences in OPG levels between animals treated with different drugs. Similarly, the OPG/RANKL ratio was similarly reduced with both types of treatment. In “OE+DM+CANA’’ group the bone trabeculae number of the femur epiphysis (p=0.042) were decreased in comparison to «OE+DM» group. LIRA did not change the histoarchitectonic parameters.CONCLUSION: Bone metabolism markers did not differ when using as canagliflozin as liraglutide. Besides, canagliflosin can lead to the activation of bone resorption, which is expressed in the femur epiphyseal trabeculae number decreasing.
Closed Mitral Valvotomy: Celebrating 100 Years of Surgical History
Authors: Bortolotti Uberto , Vendramin Igor , Milano Aldo Domenico , Livi Ugolino 
Published: May 2023

Abstract
The year 2023 marks the 100th anniversary of the first successful valvotomy for mitral valve stenosis by Elliott C. Cutler in 1923. Closed-chest mitral valve commissurotomy developed further before being replaced by an open procedure after the advent of the heart-lung machine. Currently, because of the almost complete disappearance of rheumatic disease in the Western World, mitral commissurotomies are infrequently performed in those countries, although the procedure—either closed or open—is still performed in developing countries and select patients. This review retraces the 100-year journey from a historic operation to the current era—a milestone in the treatment of patients with mitral stenosis.
Serum GFAP – pediatric reference interval in a cohort of Danish children
Authors: Tybirk Lea , Hviid Claus Vinter Bødker , Knudsen Cindy Soendersoe , Parkner Tina 
Published: May 2023

Abstract

Objectives
Glial fibrillary acidic protein (GFAP) in blood is an emerging biomarker of brain injury and neurological disease. Its clinical use in children is limited by the lack of a reference interval (RI). Thus, the aim of the present study was to establish an age-dependent continuous RI for serum GFAP in children.

Methods
Excess serum from routine allergy testing of 391 children, 0.4–17.9 years of age, was measured by a single-molecule array (Simoa) assay. A continuous RI was modelled using non-parametric quantile regression and presented both graphically and tabulated as discrete one-year RIs based on point estimates from the model.

Results
Serum GFAP showed a strong age-dependency with declining levels and variability from infants to adolescents. The estimated median level decreased 66 % from four months to five years of age and another 65 % from five years to 17.9 years of age. No gender difference was observed.

Conclusions
The study establishes an age-dependent RI for serum GFAP in children showing high levels and variability in the first years of life.
Are bacteria, fungi, and archaea present in the midtrimester amniotic fluid?
Authors: Romero Roberto , Gervasi Maria Teresa , DiGiulio Daniel B. , Jung Eunjung , Suksai Manaphat , Miranda Jezid , Theis Kevin R. , Gotsch Francesca , Relman David A. 
Published: May 2023

Abstract

Objectives
This study was conducted to determine whether bacteria, fungi, or archaea are detected in the amniotic fluid of patients who underwent midtrimester amniocentesis for clinical indications.

Methods
Amniotic fluid samples from 692 pregnancies were tested by using a combination of culture and end-point polymerase chain reaction (PCR) techniques. Intra-amniotic inflammation was defined as an interleukin-6 concentration >2,935 pg/mL.

Results
Microorganisms were detected in 0.3% (2/692) of cases based on cultivation, 1.73% (12/692) based on broad-range end-point PCR, and 2% (14/692) based on the combination of both methods. However, most (13/14) of these cases did not have evidence of intra-amniotic inflammation and delivered at term. Therefore, a positive culture or end-point PCR in most patients appears to have no apparent clinical significance.

Conclusions
Amniotic fluid in the midtrimester of pregnancy generally does not contain bacteria, fungi, or archaea. Interpretation of amniotic fluid culture and molecular microbiologic results is aided by the assessment of the inflammatory state of the amniotic cavity. The presence of microorganisms, as determined by culture or a microbial signal in the absence of intra-amniotic inflammation, appears to be a benign condition.
Human Governance Index for State Islamic Religious Councils in Malaysia
Authors: Haron Hasnah , Zainal Abidin Zubaidah , Ramli Nathasa Mazna , Mohd Ariffin Avylin Roziana , Jamil Nurul Nazlia , Alwi Kasumalinda 
Published: May 2023

State Islamic Religious Council (SIRCs) in Malaysia were established for the social welfare under the purview of state enactments in an Islamic setting. Despite the absence of a profit motive, accountability must be upheld as it is set up to be the guardian of resources so that the trust of stakeholders could be obtained. SIRCs are expected to uphold their ethics and values in their overall operations. However, a number of negative cases of SIRCs were reported in the local media which has tarnished the image of SIRCs. Thus governors of SIRCs should managed their human assets well. Human governance is the governors’ commitment to improve employees’ values and ethical behavior in the organization through their leadership, integrity fostered in the organization, training that the governors’ attended and internal control that has been put in place. The objective of the study is to examine whether Human Governance Index (HG INDEX) could be applied to SIRCs. HG INDEX comprise of 4 components which are (i) BOD Leadership, (ii) Level of Integrity Index, (iii) BOD Quantity of Training Index, and (iv) Quality of Internal Control System Index . Thirteen(13), 2019 annual reports of SIRCs were used as a basis for data collection. Based on the findings, Quality of Internal control and Level of Integrity were found to be the highest disclosed index. Overall, HG index was found to be low for SIRCs. Thus Governors of SIRCs can use the findings of the study to increase their transparency and accountability to stakeholders by focusing on HG in order to gain the public trust.
Pemanfaatan Aplikasi Google Earth Untuk Evaluasi Perbedaan Koordinat Dan Tampilan Peta GPS Yang Digunakan Nelayan di Teluk Bone
Authors: Rumpa Arham , Isman Khairudin , Tamrin Tamrin , Tandipuang Panduartama 
Published: May 2023

Tujuan penelitian ini adalah menguji perbedaan posisi koordinat dan jarak Google Earth Pro terhadap beberapa GPS kondisi statis (diam). Uji Perbedaan posisi koordinat dan jarak GPS Garmin 585 terhadap GPS Furuno GP32 Kondisi real time (jalan) dan Uji tampilan peta Google Earth Pro terhadap tampilan peta eletronik GPS Garmin 585 dan Peta Laut kertas. Metode yang di gunakan adalah observasi dimana peneliti mengadakan pengamatan secara langsung terhadap posisi lokasi koordinat suatu tempat. Data di analisis secara deskriptif dalam bentuk gambar dan tabel, untuk perhitungan nilai jarak di gunakan menu yang terdapat pada aplikasi Google Earth Pro. Hasil penelitian menunjukan bahwa titik koordinat dan tampilan berupa peta pada aplikasi Google Earth Pro kondisi statis (diam) dan off line dapat di aplikasikan untuk menentukan posisi suatu benda di permukaan laut, namun untuk kondisi kapal real time sulit untuk di aplikasikan di laut. GPS Garmin 585 kondisi statis dan real time akurasi koordinat lebih stabil dibandingkan dengan GPS Furuno GP 32. Uji akurasi beberapa alat navigasi GPS Garmin 585 pada berbagai tempat tidak ada masaalah dalam menentukan posisi koordinat suatu tempat, sedangkan peta eletroniknya itu sendiri yang berupa SD Card menunjukan adanya perbedaan tampilan masing-masing perangkat GPS Garmin 585.
Pengaruh Pemberian Pakan Protein Rendah Terhadap Kualitas Air, Profil Darah Dan Performa Produksi Ikan Patin (Pangasianodon hypophthalmus)
Authors: Zaidy Azam Bachur , Nurmalia Nayu , Kasmawijaya Adang 
Published: May 2023

Penggunaan pakan mandiri pada budidaya ikan patin dapat menurunkan biaya produksi. Kandungan protein pakan mandiri antara 18 - 22%, berakibat sisa pakan cukup tinggi dapat mencemari lingkungan budidaya. Kajian tentang pemberian pakan protein rendah yang dapat menyebabkan pencemaran lingkungan masih sangat terbatas. Tujuan penelitian adalah untuk mengevaluasi pengaruh pakan protein rendah terhadap kualitas air, profil darah dan performa produksi ikan patin. Rancangan acak dengan tiga perlakuan pakan protein 16%, 23%, dan 30% masing-masing perlakuan tiga ulangan. Benih patin dengan bobot 50 g dan dibudidayakan selama 60 hari sebanyak 20 ekor/koma dengan volume air 1,8 m3.. Parameter yang diukur meliputi Suhu, pH, Oksigen terlarut, TOM, TDS, TSS, total amonia, nitrit, nitrat, total fosfat, eritrosit, leukosit, hemoglobin, hematokrit, kelimpahan fitoplankton, laju pertumbuhan, pertambahan bobot badan, kelangsungan hidup dan konversi pakan. Hasil penelitian menunjukkan bahwa kadar amonia dan kelimpahan fitoplankton tertinggi pada pakan protein 30% dibandingkan dengan pakan protein 16% dan 23%. Kadar eritrosit, leukosit, hemoglobin dan hematokrit tidak berbeda nyata pada ketiga perlakuan. Tingkat pertumbuhan dan pertambahan berat badan yang lebih tinggi dan konversi pakan terendah pada pakan protein 30%. Berdasarkan data hasil penelitian disimpulkan bahwa pemberian pakan protein sekitar 20% tidak menyebabkan pencemaran media budidaya, dengan demikian pakan mandiri dapat digunakan dalam budidaya patin.
Struktur Komunitas dan Asosiasi Biota pada Ekosistem Lamun di Pulau Tambakulu Taman Wisata Perairan (TWP) Kapoposang Kabupaten Pangkajene
Authors: Rosalina Dwi , Jamil Khairul , Nursal Nursal 
Published: May 2023

Lamun (seagrass) adalah tumbuhan berbunga (Angiospermae) yang dapat tumbuh dengan baik dalam lingkungan laut dangkal. Penelitian dengan judul Struktur komunitas ekosistemlamun dan Asosiasi Biota Pada Ekosistem Lamun di Pulau TambakuluTaman Wisata Perairan (TWP) Kapoposang Kabupaten Pangkajene Kepulauan. Penelitian dilakukan pada bulan Juni 2021. Tujuan penelitian yaitu mengetahui jenis lamun dan menghitung kerapatan, penutupan serta mengetahui biota yang berasosiasi pada ekosistem lamun. Metode yang digunakan dalam kegiatan ini menggunakan metode transek kuadrat yang terdiri dari transek (garislurus) dan frame berbentuk kuadrat (bingkai berbentuk segi empat yang diletakkan pada garis), stasiun pengamatan ada 4 stasiun, setiap stasiun dibagi 3 transek garis. Pengamatan lamun di lapangan meliputi jenis lamun, kerapatan, Penutupan danbiota yang berasosiasi. Hasil pengamatan menunjukkan bahwa terdapat dua jenis lamun Cymodocea rotundata dan Thalassiahemprichii. Berdasarkan hasil pengamatan tutupan ekosistem lamun 23,97 % masuk dalam kondisi rusak dengan kategori kurangsehat/kurang kaya. Dua jenis biota yang ditemukan hidup berasosiasi dengan lamun adalah Cypraea tigris dan Protoreasternodosus.
EFFECT OF PLASMA-CHEMICALLY ACTIVATED AQUEOUS SOLUTIONS ON THE PROCESS OF DISINFECTION OF FOOD PRODUCTION EQUIPMENT
Authors: Pivovarov О. , Kovaliova О. , Koshulko V. 
Published: May 2023

Abstract. In food production, it is essential to implement preventive measures aimed at improving the quality of products, namely decontaminating them of microorganisms causing food poisoning. Effective sanitisation of food production equipment allows preventing products’ contamination by pathogenic microflora and by microorganisms that lead to spoilage of food. The paper presents a study of the effect of plasma-chemically activated aqueous solutions on the process of disinfection of food production equipment. Activated aqueous solutions have been characterised, and it has been shown how they affect pathogenic microflora present on the surfaces of equipment involved in meat production and processing. Analysis of microbiological indicators (QMAFAnМand coliform bacteria) has shown that the number of pathogenic bacteria decreased by half on all surfaces of the processing room even at the peroxide concentration 100 mg/l, while at the concentration 500 mg/l, we observed complete destruction of pathogenic microflora both in the poultry slaughter room and in the diseased animal slaughterhouse. The disinfecting properties of plasma-chemically activated aqueous solutions in the process of production of chicken mincehave been analysed. After the surfaces of the cutters were treated with the activated aqueous solutions having the peroxide concentration 500 mg/l, the equipment was found to be completely sterile: no microflora was detected in the wipe samples, and this dynamics was observed for 7 days. The use of the disinfectant proposed stops the development of any microflora on the surface of technological equipment. The level of microbiological contamination of the finished meat product (chicken mince) after treating the equipment with plasma-chemically activated solutions has been studied, their peroxide concentrations being 100 to 700 mg/l. No pathogenic microflora (in particular, nocoliform bacteria and mould) was detected in the finished meat products obtained after the equipment was treated with the disinfectant solution at a concentration higher than 500 mg/l. Plasma-chemically activated aqueous solutions with the concentration of peroxides 500 mg/l are considered optimal for disinfection of the technological surfaces and equipment of meat processing enterprises, since they ensure complete removal of pathogenic microflora and allow obtaining a product free from pathogens.
THE AMINO ACID COMPOSITION OF MEAT PRODUCTS TREATED WITH PREPARATIONS OF MICROBIAL ORIGIN
Authors: Danylenko S. , Naumenko O. , Ryzhkova T. , Fediaiev V. , Verbytskyi S. , Korol Ts. 
Published: May 2023

Fermentation in the technology of dry-cured meat products helps to create products with high sensory characteristics and an extended shelf life. The purpose of this work was to study how bacterial and enzyme preparations affected the accumulation of free amino acids in dry-cured meat products.
The work considers how the preparation Iprovit-Lakmik based on the cultures L. plantarum, L. rhamnosus, L. casei, and Micrococcus varians acts on the accumulation of free amino acids during the ripening of dry-cured sausages, and how the bacterial preparation Iprovit-MKS based on the cultures Lactoba plantarum, L. rhamnosus, and Staphylococcus simulans and the enzyme preparation Protolad acts on proteolysis during the ripening of dry-cured whole-muscle products from pork and beef. Fermentation was carried out in a climatic chamber at a temperature required by the technological process of accelerated ripening of fermented sausages, using bacterial and enzyme preparations. The starter culture Iprovit-Lakmik was added in the amount 0.05% to the volume of the sausage mince prepared in accordance with the formulation of the dry-cured sausage Zhytomyrska. The preparations Protolad and Iprovit-MKS were added at the stage of injecting the balyk (cured fillet) Darnitsky. Samples with no preparations added were the controls. The amino acid composition of proteins was determined by ion-exchange chromatography on an automatic amino acid analyser Biotronik LC2000. The total content of free cyclic amino acids was determined by the Hull method, and that of acyclic amino acids by the Gomez method, using colourimetry.
It has been found that after fermentation, each product had its own characteristics of the qualitative and quantitative accumulation of free amino acids. Adding the preparation Iprovit-Lakmik to raw meat allowed directed biochemical transformations with the formation of a significant amount of free amino acids, which exceeded the control by 115.86 mg/100 g of dry matter. The enzyme preparation Protolad has a positive effect on the chemical and physicochemical characteristics of salted products from pork and beef. It has been proved that its use activates the breakdown of muscle tissue proteins and increases the pool of free amino acids. In the test samples from pork and beef, the content of free amino acids increased, respectively, by 1.7 times and 3.4 times, and that of non-essential amino acids by 1.4 times and 1.3 times respectively, compared with the control. In the samples with the bacterial preparation Iprovit-MKS, the total amount of amino acids increased significantly: by 32% for beef balyk and by 20% for pork balyk.
Innovative lipid-lowering therapy: experience of inclisiran use in the Republic of Belarus
Authors: Medvedeva E. A. , Grigorenko E. A. , Mitkovskaya N. P. 
Published: May 2023

The article reflects modern aspects of lipid-lowering therapy, based on the as­sessment of cardiovascular risk, and the possibilities of triple therapy, including statins, ezetimibe, and inclisiran.We present our own data on the use of the drug inclisiran in patients with lipid metabolism disorders in the framework of secondary and primary cardiovascular prevention. Low-density lipoprotein levels at different times after the injection is described. The potential of innovative lipid-lowering therapy in liver transplant recipients in the long-term postoperative period are discussed.The addition of inclisiran to statin and ezetimibe therapy is safe and leads to a decrease in low-density lipoprotein levels by more than 50% of baseline values in the general population.