bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping Mechanism and Food Security in Pandemic Times: A Systematic Literature Review
Authors: Budiawati Yeni , Natawidjaja Ronnie S , Utomo Dhanan S , Perdana Tomy , Karmana Maman H 
Published: January 2023

Abstract
The COVID-19 pandemic occurs worldwide and is the second pandemic to be declared as a global pandemic after the avian influenza pandemic. Individual and household coping strategies are essential when dealing with such a crisis. This systematic literature review synthesizes published evidence on coping mechanisms and food security in pandemic situations and looks at future research directions based on the gaps found. The number of publications on coping strategies and food security has increased over time, especially during the Covid 19 pandemic. This topic interestresearcher and academics from various countries and disciplines. Data analysis was carried out using the endnote X9 version following the preferred reporting items for systematic review and meta-analysis (PRISMA). The data was collected from the Proquest, Ebscohost, and Scopus databases. This review’s result is that most publications are in the 2019-2022 timeframe, area of health sciences, quantitative methods, empirical data, and individual case studies. The following review is an analysis based on the research context divided based on sub-criteria: pandemic impact, the main outcome, geographic location, economic development, and basic theory. The findings show that the impact of the pandemic that has been widely studied is about environmental quality and socioeconomic impact; no mention of theory; food security; in Asia; high-income and low-income countries; with the aim of policy development. The next review analyzes the main outcomes of food security and coping strategies. Based on this review, the most studied dimension of food security is accessibility using the HFIAS instrument and cross-sectional survey research design. Furthermore, there are fewpublications on utility and stability dimensions, especially the relationship between the four dimensions of food security, availability, accessibility, utility, and stability, qualitatively and quantitatively. In addition, publications regarding the relationship between food security from its four dimensions and coping strategies both qualitatively and quantitatively are also very limited. These findings create opportunities for future researchers to study them.
An effective method for preoperative distinguishing Gastric duplication cysts and Adrenal cysts in children
Authors: Shu Zhen , Zhao Peng , Wang Cao , yin Jia , Liu Xiang , Liu Bin 
Published: January 2023

Abstract
Background: Gastric duplication cysts (GDC) are a rare congenital disease primarily found in the left adrenal region in neonates and children. Due to a lack of typical clinical manifestations, GDCare often preoperatively treated as adrenal cysts (AC).
Methods: We retrospectively report six child cases of retroperitoneal cysts presenting as left adrenal masses between January 2012 and January 2022. Patients aged from 10 months to 10 years, including three females and three males, were all treated by surgery and discharged without serious complications. Clinical data such as medical history, clinical manifestations, auxiliary examination, operation process, and postoperative pathological diagnosis were examined in detail.
Results: Only one male had mild epigastric pain that could be relieved spontaneously, and the rest had no obvious clinical manifestations. Endocrinological evaluations indicated no positive findings. The stomach-cyst distance in computerized tomography (CT) scans and cyst-kidney distance in ultrasound scans were significantly different in the patient with GDC. All patients underwent surgical resection and were preoperatively diagnosed with a left AC. One patient underwent open cystectomy, and the others underwent laparoscopic cystectomy. Surgical access was transperitoneal in five patients and retroperitoneal in one patient. Mean operative time was 129.7±15.46 min, mean oral feeding time was 9.0±2.58hours, and mean length of hospital stay was 6.5±0.96 days. No serious complications were observed, and their pathological diagnosis was AC, except for one case of GDC. All patients recovered and had no complications during follow-up.
Conclusion: GDC is easily misdiagnosed as left AC.Accurate diagnoses are mainly based on intraoperative findings and postoperative pathological examinations. However, in addition to gastrointestinal symptoms, such as abdominal pain and vomiting, the stomach-cyst distance in CT scans and cyst-kidney distance in ultrasound scans can be used as critical evidence for preoperative diagnosis GDC or AC. Laparoscopic surgery is safe and effective, and a transperitoneal approach is recommended for GDC.
Folic Acid-decorated and PEGylated Graphene Quantum Dots as efficient Tamoxifen delivery system against breast cancer cells: in vitro studies
Authors: Amraee Noora , Majd Ahmad , Torbati Maryam Bikhof , Shaabanzadeh Masoud 
Published: January 2023

Abstract
Nano-drug delivery systems have provided a platform for improving the formulations of targeted cancer therapy. Graphene quantum dots (GQDs) possess potential properties for the targeted transport and tracking of anticancer medication to tumor cells. For this purpose, the synthesized GQDs were decorated with folic acid for better binding to folate-positive breast cancer cells and methoxy polyethylene glycol (mPEG2000) for a longer lifetime, and finally loaded with anticancer drug tamoxifen (TMX). The synthesized nano-drugs were characterized using FTIR, XRD, UV-vis, PL, HRTEM, FESEM, and DLS analytical devices. Based on the obtained data, the average hydrodynamic diameter of particles dissolved in water was 294.7 nm and the size of dehydrated particles was between 3 and 153 nm. PL data showed that prepared nanoparticles have an emission wavelength of 438 nm, which is in the blue fluorescent wavelength range, thus making these nanoparticles suitable for cell imaging. The encapsulation efficiency and loading percentage of tamoxifen in nanoparticles were calculated at about 52.5% and 30%, respectively, and cumulative drug release reached 89% within 42 hours. The cytotoxicity effects of nanoparticles on MCF-7 cell line were investigated. The targeted mPEG-GQDs-FA/TMX (TMX-FPGs) nano-drug was more toxic than free TMX drug on MCF-7 cells and had reduced side effects on healthy HDF cells. TMX-FPGs induced apoptosis cell death in cancer cells, significantly. The confocal cell imaging experiments showed that TMX-FPGs are appropriate for monitoring and targeting MCF-7 cancer cells. These data have approved the potency of TMX-FPGs against breast cancer cells.
HCV spontaneous clearers showed low senescence profile in people living with HIV
Authors: Lara-Aguilar Violeta , Valle-Millares Daniel , Crespo-Bermejo Celia , Llamás-Adán Manuel , Grande-García Sergio , Cortijo-Alfonso María Engracia , Martín-Carbonero Luz , Domínguez Lourdes , Ryan Pablo , Santos Ignacio de los , Bartolomé-Sanchez Sofía , Briz Verónica , Fernández-Rodríguez Amanda 
Published: January 2023

Abstract
Background: Co-infection with Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) increase immune activation, inflammation and oxidative stress that could lead to premature senescence. Different HCV infection, either acute or chronic infection, could lead to distinct premature cellular senescence in people living with HIV (PLWHIV).
Methods: Observational study in 116 PLWHIV with different HCV status: i) n=45 chronically infected with HCV (CHC); ii) n=36 individuals who spontaneously clarify HCV (SC); iii) n= 35 HIV controls. Oxidative stress biomarkers were analysed at lipid, DNA, protein, and nitrates levels, as well as total antioxidant capacity and glutathione reductase enzyme. Replicative senescence was evaluated by relative telomere length (RTL) measurement. Additionally, twenty-six markers of senescence-associated secretory phenotype (SASP) were analysed by Multiplex Immunoassay (Luminex xMAP technology). Differences were evaluated by generalized linear model (GLMs) adjusted by most significant covariates.
Results: The SC group had a senescence signature similar to the HIV control group and slightly lower SASP levels. However, significant differences were observed with respect to CHC group, where an increase in the nitrate concentration [aAMR=1.73 (1.27-2.35), p<0.001, q=0.009]) and the secretion of 13 SASP-associated factors (GM-CSF, IFN-γ, IL-1β, IL-2, IL-8, IL-13, TNF-α, IL-1α, IL-1RA, IL-7, IL-15, IP-10, SCF; q<0.1) was detected. CHC group also showed higher values of IL-1α, IP-10 and PIGF-1 than HIV controls.
Conclusion: SC showed slightly lower senescence profile to HIV group indicating a more efficient control of viral-induced senescence. Chronic HCV infection in PLWHIV lead to nitrate accumulation and elevated plasma SASP biomarkers favouring the establishment of vial persistence.
Dynamics of cellular senescence markers after HCV elimination in people living with HIV
Authors: Lara-Aguilar Violeta , Valle-Millares Daniel , Crespo-Bermejo Celia , Grande-García Sergio , Llamás-Adán Manuel , Cortijo-Alfonso María Engracia , Martín-Carbonero Luz , Domínguez Lourdes , Ryan Pablo , Santos Ignacio de los , Bartolomé-Sanchez Sofía , Vidal-Alcantara Erick Joan , Fernández-Rodríguez Amanda , Briz Verónica 
Published: January 2023

Abstract
Background: Previously, we identified that different HCV infection, either acute or chronic infection in people living with HIV (PLWHIV) drives dissimilar cellular senescence profile. However, variations in these profiles after HCV clearance, spontaneously or with direct-acting antivirals (DAAs), remains unclear.
Methods: Longitudinal observational study (48 weeks of follow-up) in 70 PLWHIV with different HCV status: 23 PLWHIV with active HCV-chronic infection (CHC) before and after HCV eradication with DAAs, 12 PLWHIV who spontaneously clarify the HCV (SC), and 35 PLWHIV controls (HIV), all of them aviremic. Plasma oxidative stress biomarkers were quantified at DNA, lipid, protein, and nitrate levels, as well as the total antioxidant capacity and glutathione reductase enzyme. The replicative senescence was evaluated by relative telomere length (RTL) measurement by Monochromatic Multiplex Real-Time Quantitative PCR (MMqPCR). Finally, twenty-six factors associated to Senescence-Associated Secretory Phenotype (SASP) were characterized by Multiplex Immunoassay (Luminex xMAP technology). Differences in senescence markers was evaluated by generalized linear mixed model (GLMMs) for longitudinal series or generalized linear model (GLMs) for non-paired comparisons.
Results: During follow-up, the SC group achieved a reduction of oxidative stress levels at glutathione enzyme and lipid peroxidation level. The secretion of SASP markers increased, being still lower than HIV group. elimination of chronic HCV infection by DAAs allowed an overall improvement of oxidative stress levels and SASP markers to levels like those of the HIV group. No significant differences were observed in telomere shorting between groups after follow-up.
Conclusions: As the time since spontaneous resolution of HCV infection increased, patients had an improved senescence profile compared to the HIV control group, with a reduction in oxidative stress and SASP markers. Elimination of chronic HCV infection by DAAs led to a partial improvement of the senescence profile by restoring oxidative stress levels. However, although some SASP markers reached levels like those of the HIV group, others remained altered.
A Review on the Natural Components Applied as Lead Compounds
for Potential Multi-target Anti-AD Theranostic Agents
Authors: Kou Xiaodi , Shi Xuli , Pang Zi , Yang Aihong , Shen Rui , Zhao Lihua 
Published: January 2023

Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease that seriously affects
the health and quality of life of the elderly. Its pathogenesis is very complex and there is
still a lack of effective clinical drugs to treat or control the development of AD. Studies
have shown that β-amyloid (Aβ) deposition, tau protein hyperphosphorylation, reduced
levels of brain cholinergic transmitters, and oxidative stress are the main causes of AD.
Furthermore, recent studies showed that metal dyshomeostasis could relate to all the
above pathogenesis of AD and was a key factor in the development of AD. Natural compounds
and their derivatives have multi-target therapeutic effects on AD, and they also
have the advantages of low toxicity, and low cost, which are important directions for anti-
AD drugs. Meanwhile, early detection may play an important role in preventing the development
of AD. The concept of “theranostic agent” combining molecular imaging
probes and therapeutic drugs has emerged in recent years. Fluorescence imaging has
been widely studied and applied because of its non-invasive, high resolution, high sensitivity,
rapid imaging, and low cost. However, at present, most of the research methods in
this field use individual therapeutic or diagnostic reagents, which is not conducive to exploring
the optimal treatment time window and drug efficacy. Therefore, this work reviewed
the natural compounds and their derivatives which all have been studied for both
the in vitro and in vivo therapeutic and diagnostic anti-AD activities. At last, structure
and activity relationship (SAR) was discussed and potential AD theranostic natural
agents were put forwarded to provide a more detailed theoretical basis for the further development
of drugs with diagnostic and therapeutic effects in AD.
Discoidin Domain Receptor 1 Inhibitors: Advances and Future Directions
for Novel Therapeutics with Aid of DNA Encoded Library Screens and Artificial
Intelligence
Authors: Sanawar Rahul , Sahayasheela Vinodh J. , Sarath Praseetha , Dan Vipin Mohan 
Published: January 2023

Abstract:
Discoidin domain receptor (DDR) 1, a collagen binding receptor kinase, is an intensively
researched therapeutic target for cancer, fibrosis and other diseases. The majority of early known
DDR1 inhibitors targeted the ATP binding pocket of this enzyme that shares structural similarities
with other kinase pockets across the biological system. This structural similarity of DDR1 kinase
with other protein kinases often leads to “off target “toxicity issues. Understanding of uniqueness in
DDR:ATP–phosphate-binding loop (P-loop), DNA encoded library screen, structure-guided optimization
studies, and machine learning drug design platforms that come under the umbrella of artificial
intelligence has led to the discovery of a new array of inhibitors that are highly selective for DDR1
over DDR2 and other similar kinases. Most of the drug discovery platforms concentrated on the
ATP binding region of DDR1 kinase and never looked beyond this region for novel therapeutic options.
Recent findings have disclosed the kinase-independent functions of DDR1 in immune exclusion,
which resides in the extracellular collagen-binding domain, thus opening avenues for the development
of inhibitors that veer away from targeting ATP binding pockets. This recent understanding
of the functional modalities of DDR1 opens the complexity of targeting this transmembrane protein
as per its functional prominence in the respective disease and thus demands the development of
specific novel therapeutics. The perspective gives a short overview of recent developments of
DDR1 inhibitors with the aid of the latest technologies, future directions for therapeutic development,
and possibility of combinational therapeutic treatments to completely disengage functions of
DDR1.
Studi Perencanaan Embung sebagai Upaya Pengendalian Banjir Sungai Kemuning Kabupaten Sampang Madura Provinsi Jawa Timur
Authors: Aditiya Achmad Rizkiawan , Dermawan Very , Asmaranto Runi 
Published: January 2023

Embung merupakan bangunan air yang berfungsi menampung air hujan dan air limpasan. SungaiiKemuning yang berlokasikan di Kabupaten Sampang, Madura dengan panjang sungai utama kurang lebih 58 km tiap tahunnya saat musim hujan tidak dapat menampung debit banjir yang terjadi dan juga mengalami kekeringan pada saat musing kemarau. Pembangunan embung diharapkan mampu menahan air banjir untuk mengurangi volume debit air yang mengalir dan dapat digunakan di saat musim kemarau terjadi. Pada perencanaan pelimpah direncanakan 3 lokasi embung pada Sungai Kemuning. Tujuanistudi iniiadalah untuk mengetahui besar debit banjir rancangan sungai Kemuning serta pengaruh adanya pembangunan embung terhadap besar reduksi banjir yang terjadi. Perhitungan debit banjir rancangan menggunakan metode Nakayasu. Analisa menggunakan aplikasi HEC-RAS 6.2 dengan menggunakan debit banjir Q25th. Menghitung reduksi dengan adanya perencanaan embung pada sungai Kemuning. Hasil analisa debit banjir rancangan Q25th pada Embung Daleman didapatkan sebesar 255,102 m3/dt, pada Embung Rohayu sebesar 353,868 m3/dt, dan pada Embung Komis sebesar 344,046 m3/dt. Perencanaan 3 embung pada studi ini mereduksi banjir sebesar 17,79% berdasarkan penampang yang melimpas dan 4,85% berdasarkan debit yang terjadi.
Retarding basin is a water structure that functions to collect rainwater and runoff water. The Kemuning River which is located in Sampang Regency, Madura, with the main river length of approximately 58 km, every year during the rainy season cannot accommodate the flood discharge but drought during the dry season. The construction of the retarding basin is expected to be able to reduce the volume of flood discharge and also can be used on dry season. It is planned to have 3 locations of retarding basins on the Kemuning River. Calculation of design flood discharge using Nakayasu method. The Q25th design flood discharge at Daleman was 255.102 m3/s, at Rohayu was 353.868 m3/s, and at Komis was 344.046 m3/s. Analysis using the HEC-RAS 6.2 application of Q25th flood discharge. The highest water depht in the downstream Kemuning River is 2.15 m on the left and 1.83 m on the right cross-section. The planning of 3 retarding basins has a flood reduction of 17.79% based on the overflow section and 4.85% based on previous flood design discharge.
The Accuracy of a Web-Based Visual Acuity Self-assessment Tool Performed Independently by Eye Care Patients at Home: Method Comparison Study
Authors: Claessens Janneau , van Egmond Juultje , Wanten Joukje , Bauer Noël , Nuijts Rudy , Wisse Robert 
Published: January 2023

Background
Telehealth solutions can play an important role in increasing access to eye care. Web-based eye tests can enable individuals to self-assess their visual function remotely without the assistance of an eye care professional. A web-based tool for self-assessing visual acuity (VA) has previously been studied in controlled, supervised conditions. The accuracy of this tool when performed independently by patients in their home environment, using their own devices, has not yet been examined.

Objective
The objective of this paper was to examine the accuracy of a web-based tool with respect to measuring VA in ophthalmic patients in their home environment, compared with a conventional in-hospital assessment using a Snellen chart (the gold standard).

Methods
From April through September 2020, consecutive adult patients with uveitis at the University Medical Center Utrecht, the Netherlands, performed the web-based VA test at home (the index test) before their upcoming conventional VA assessment at the hospital (the reference test). The agreement between the 2 tests was assessed by the Bland-Altman analysis. Additional analyses were performed to investigate associations between clinical characteristics and the accuracy of the web-based test.

Results
A total of 98 eyes in 59 patients were included in the study. The difference in VA between the index and reference tests was not significant, with a mean difference of 0.02 (SD 0.12) logMAR (P=.09) and 95% limits of agreement of –0.21 to 0.26 logMAR. The majority of the differences (77%) fell within the predetermined acceptable deviation limit of 0.15 logMAR. In addition, no patient characteristics or clinical parameters were found to significantly affect the accuracy of the web-based test.

Conclusions
This web-based test for measuring VA is a valid tool for remotely assessing VA, also when performed independently by patients at home. Implementation of validated web-based tools like this in the health care system may represent a valuable step forward in revolutionizing teleconsultations and can provide individual patients with the opportunity to self-monitor changes in VA. This is particularly relevant when the patient’s access to ophthalmic care is limited. Future developments should focus on optimizing the testing conditions at home to reduce outliers.
The Role of Compassionate Technology in Blended and Digital Mental Health Interventions: Systematic Scoping Review
Authors: van Lotringen Charlotte , Lusi Benedetta , Westerhof Gerben J , Ludden Geke D S , Kip Hanneke , Kelders Saskia M , Noordzij Matthijs L 
Published: January 2023

BackgroundAn essential value in mental health care is compassion: awareness of suffering, tolerating difficult feelings in the face of suffering, and acting or being motivated to alleviate suffering. Currently, technologies for mental health care are on the rise and could offer several advantages, such as more options for self-management by clients and more accessible and economically viable care. However, digital mental health interventions (DMHIs) have not been widely implemented in daily practice. Developing and evaluating DMHIs around important mental health care values, such as compassion, could be key for a better integration of technology in the mental health care context.ObjectiveThis systematic scoping review explored the literature for previous instances where technology for mental health care has been linked to compassion or empathy to investigate how DMHIs can support compassion in mental health care.MethodsSearches were conducted in the PsycINFO, PubMed, Scopus, and Web of Science databases, and screening by 2 reviewers resulted in 33 included articles. From these articles, we extracted the following data: technology types, goals, target groups, and roles of the technologies in the intervention; study designs; outcome measures; and the extent to which the technologies met a 5-step proposed definition of compassion.ResultsWe found 3 main ways in which technology can contribute to compassion in mental health care: by showing compassion to people, by enhancing self-compassion in people, or by facilitating compassion between people. However, none of the included technologies met all 5 elements of compassion nor were they evaluated in terms of compassion.ConclusionsWe discuss the potential of compassionate technology, its challenges, and the need to evaluate technology for mental health care on compassion. Our findings could contribute to the development of compassionate technology, in which elements of compassion are explicitly embedded in its design, use, and evaluation.