bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-destructive evaluation of melt-extruded part quality using in situ data
Authors: Jilludimudi Veera Harsha Vardhan , Zhou Daniel , Rubstov Eric , Gonzalez Alexander , Daknis Will , Gunn Erin , Prawel David 
Published: September 2023

Purpose
This study aims to collect real-time, in situ data from polymer melt extrusion (ME) 3D printing and use only the collected data to non-destructively identify printed parts that contain defects.

Design/methodology/approach
A set of sensors was created to collect real-time, in situ data from polymer ME 3D printing. A variance analysis was completed to identify an “acceptable” range for filament diameter on a popular desktop 3D printer. These data were used as the basis of a quality evaluation process to non-destructively identify spatial regions of printed parts in multi-part builds that contain defects.

Findings
Anomalous parts were correctly identified non-destructively using only in situ collected data.

Research limitations/implications
This methodology was developed by varying the filament diameter, one of the most common reasons for print failure in ME. Numerous other printing parameters are known to create faults in melt extruded parts, and this methodology can be extended to analyze other parameters.

Originality/value
To the best of the authors’ knowledge, this is the first report of a non-destructive evaluation of 3D-printed part quality using only in situ data in ME. The value is in improving part quality and reliability in ME, thereby reducing 3D printing part errors, plastic waste and the associated cost of time and material.
Research governance for change: funding project-based measures in the field of responsible research and innovation (RRI) and their potential for organisational learning
Authors: Wicher Magdalena Julia , Frankus Elisabeth 
Published: September 2023

Purpose
This paper aims to look at the implementation of project-funded research governance and its potential to induce organisational learning on responsible research and innovation (RRI). This paper analysed what types of organisational learning and change can take place within organisations of an Europe-funded project and to what extent. This paper examined whether and how change occurs and how it is shaped and co-produced with other orderings.

Design/methodology/approach
The paper is based on materials and evidence collected while working on the internal evaluation of a Horizon 2020-funded project. Analysis of the results of the mixed methods evaluation design was used to characterise occurrences of organisational learning and change.

Findings
The authors identified different forms of learning (single-loop learning, double-loop learning, reflexive and reflective learning and situational learning). The extent of learning that could lead to long-lasting organisational change was limited. This was due to the project-based and organisational design, the key-based definition of RRI and the indeterminacy of what constitutes learning and change – both at the level of funding and performing the project. For organisational change to occur, the authors argue for governance mechanisms based on reflexive learning that consider a range of structural conditions and measures.

Originality/value
Organisational learning plays an important role in change processes, which has so far been given too little consideration concerning the governance and implementation of RRI through project-based funding. The authors argue for a restructuring of governance and funding mechanisms to create more space for reflexivity and learning.
Effectiveness of a tubular heat exchanger and a novel perforated rectangular flow-deflector type baffle plate with opposing orientation
Authors: Rahman Md Atiqur 
Published: September 2023

Purpose
The purpose of this experimental research was to examine a novel axial heat exchanger featuring swirling air movement over heated tubes. This apparatus is designed with perforated circular baffle plates complemented by rectangular air deflectors operating at different inclination angles. The tubes were arranged in a consistent layout parallel to the longitudinal airflow. The deflector’s heightened air-side turbulence initiates the frenzied motion, escalating the surface heat transfer rate.

Design/methodology/approach
The tubes maintained a constant heat flux condition over the surface. In each baffle plate, eight deflectors with identical inclination angles were devised in a reverse position, forming a rotation of air inside a circular duct that held tubes (carrying hot water) which elevated air-side turbulence, thereby enhancing the rate of heat transference on the surface. The baffle plates were equally situated from each other at changing pitch ratios. The Reynolds quantity was preserved in the scope of 16,000–30,000. The performance of the heat exchanger considering pitch ratios and inclination angles was examined.

Findings
The research indicates that when examined under similar conditions, an exchanger with a deflector baffle plate shows a strong dependence on the pitch ratio and inclination angle with a mean rise of 0.19 times in thermal enhancement factor at an inclination angle of 30° and a pitch ratio of 1.2 contrasted with an exchanger with segmental baffle plates.

Originality/value
The result shows the dependence of pitch ratio, Reynolds number and inclination on the heat transfer and friction factor rate.
Prostate cancer therapy outcome prediction: are miRNAs a suitable guide for therapeutic decisions?
Authors: Konoshenko MariaYu , Laktionov Pavel , Bryzgunova Olga 
Published: September 2023

AbstractBackgroundRadical prostatectomy, radiotherapy, chemotherapy, and androgen‐deprivation therapy are among the most common treatment options for different forms of prostate cancer (PCa). However, making therapeutic decisions is difficult due to the lack of reliable prediction markers indicating therapy outcomes in clinical practice. The involvement of miRNAs in all mechanisms of the PCa development and their easy detection characterize them as attractive PCa biomarkers. Although there are extensive data on the role of miRNAs in PCa therapy resistance and sensitivity development, the issues of whether they could be used as a guide for therapy choice and, if so, how we can progress toward this goal, remain unclear. Thus, generalizable reviews and studies which summarize, compare, and analyze data on miRNA involvement in responses to different types of PCa therapies are required.ObjectivesData on the involvement of miRNAs in therapy responses, on the role of cross‐miRNA expression in different therapies, and on miRNA targets were analyzed in order to determine the miRNA‐related factors which can lend perspective to the future development of personalized predictors of PCa sensitivity/resistance to therapies.Materials and methodsThe data available on the miRNAs associated with different PCa therapies (resistance and sensitivity therapies) are summarized and analyzed in this study, including analyses using bioinformatics resources. Special attention was dedicated to the mechanisms of the development of therapy resistance.Results and discussionA comprehensive combined analysis of the current data revealed a panel of miRNAs that were shown to be most closely associated with the PCa therapy response and were found to regulate the genes involved in PCa development via cell proliferation regulation, epithelial‐mesenchymal transition (EMT), apoptosis, cell‐cycle progression, angiogenesis, metastasis and invasion regulation, androgen‐independent development, and colony formation.ConclusionThe selected miRNA‐based panel has the potential to be a guide for therapeutic decision making in the effective treatment of PCa.
Parental age at birth and biomarkers of fecundity in young Danish men
Authors: Ernst Andreas , Brix Nis , Gaml‐Sørensen Anne , Arendt Linn Håkonsen , Toft Gunnar , Tøttenborg Sandra Søgaard , Hougaard Karin Søring , Bonde Jens Peter Ellekilde , Ramlau‐Hansen Cecilia Høst 
Published: September 2023

AbstractBackgroundHigh parental age is associated with adverse birth and genetic outcomes, but little is known about fecundity in male offspring.ObjectivesWe investigated if high parental age at birth was associated with biomarkers of male fecundity in a large population‐based sample of young men.Materials and methodsWe conducted a study of 1057 men from the Fetal Programming of Semen Quality (FEPOS) cohort, a sub‐cohort of sons born 1998–2000 into the Danish National Birth Cohort. Semen characteristics and reproductive hormone concentrations were measured in samples provided by the men 2017–2019. Testis volume was determined by self‐measurement. Data on the parental age was drawn from registers. Adjusted relative difference in percentage with 95% confidence intervals were estimated for each outcome according to pre‐specified maternal and paternal age groups (< 30 (reference), 30–34 and ≥ 35) as well as for combinations of parental age groups, using multivariable negative binomial regression models.ResultsWe did not observe consistent associations between parental age and biomarkers of fecundity, although sons of mothers ≥ 35 years had lower sperm concentration (−15% (95% CI: −30, 3)) and total sperm count (−10% (95% CI: −25, 9)). The analysis with parental age combinations showed lower sperm concentration with high age of the parents (both ≥ 35 years: −27%, 95% CI: −40, −19) when compared to the reference where both parents were below 30 years.Discussion and conclusionWe found no strong association between higher parental age and biomarkers of fecundity in young men. However, we cannot exclude poorer semen characteristics in sons born by older mothers or with high age of both parents.
Reflecting on insight and insights into reflection: a systematic review of insight and reflection in post graduate medical education
Authors: Price Neil , Jowsey Tanisha , Weller Jennifer 
Published: September 2023

AbstractBackgroundClinicians recognize insight as important for safe independent medical practice. Clinical education literature focuses on self‐reflection. The aim of this review is to describe how clinical educators conceptualize reflection and ask is it analogous to how clinicians conceptualize insight?MethodsUsing PRISMA guidelines, a systematic review of the literature around insight and reflection in postgraduate medical education was undertaken. A thematic analysis of the concepts of insight and reflection was performed.ResultsA total of 75 reports were included in the analysis. The literature focussed predominantly on reflection with little discussion of insight. Three main themes were generated: episodic reflection; cyclic reflection; reflection as a state. Reflection as a state seemed to be the professional quality most often aspired to but was less well defined in terms of educational interventions. When more than one model was described, it was often with a reflective state being the ideal that episodic or cyclic reflection may approximate. It is not clear that it is possible to progress up the hierarchy.ConclusionWe present a novel description of a hierarchy from discrete episodes of reflection, to cyclic processes that involve reflection, through to a state in which the practitioner is reflective. There is no unified understanding of how an individual ascends this hierarchy, or a cohesive description of what insight is for an independent medical practitioner. This review highlights the need for research into how practicing clinicians conceptualize and characterize insight in their training and practice.
Multi‐trial, aggregated, individual participant data mega‐analysis of short‐term antidepressant versus mood stabilizer monotherapy of bipolar type II major depressive episode
Authors: Amsterdam Jay D. , Xu Colin 
Published: September 2023

AbstractBackgroundFew studies have systematically examined the safety and effectiveness of antidepressant versus mood stabilizer monotherapy of bipolar II depression. To date, there are no aggregated or mega‐analyses of prospective trials of individual participant‐level data (IPD) to inform future treatment guidelines on the relative safety and effectiveness of antidepressant or lithium monotherapy.MethodsData from a series of four independent, similarly designed trials of antidepressant or lithium monotherapy (where longitudinal IPD were available) (n = 393) were aggregated into an IPD dataset (i.e., mega‐analysis). Hierarchical log‐linear growth models were used to analyze primary outcome of change over time in Hamilton Rating Scale for Depression (HRSD) scores; while secondary outcomes examined Clinical Global Impressions severity (CGI/S) and change (CGI/C) scores, and change over time in Young Mania Rating (YMR) scores.ResultsRelative to lithium monotherapy, antidepressant monotherapy demonstrated significantly greater symptom reduction on HRSD scores across time (b = −2.33, t = −6.68, p < 0.0001), significantly greater symptom reduction on the CGI/S across time (b = −0.414, t = −6.32, p < 0.001), and a significant improvement in CGI/C across time (b = −0.47, t = −7.43, p < 0.0001). No differences were observed in change over time for YMR scores between antidepressant and lithium monotherapy (b = 0.06, t = 0.49, p = 0.62).ConclusionFindings from this IPD mega‐analysis of bipolar II depression trials suggest a divergence from current evidence‐based guidelines recommending combined mood stabilizer plus antidepressant therapy. The current mega‐analysis suggests that antidepressant monotherapy may provide superior short‐term effectiveness without clinically meaningful increase in treatment‐emergent hypomanic symptoms compared to lithium monotherapy.
Systematic review evaluating the influence of the prosthetic material and prosthetic design on the clinical outcomes of implant‐supported multi‐unit fixed dental prosthesis in the posterior area
Authors: Pjetursson Bjarni E. , Sailer Irena , Merino‐Higuera Elizabeth , Spies Benedikt Christopher , Burkhardt Felix , Karasan Duygu 
Published: September 2023

AbstractObjectiveThe objectives of the study were to assess the survival, failure, and technical complication rates of implant‐supported fixed dental prosthesis (iFDPs) with pontic or splinted crown (iSpC) designs in the posterior area and compare the influence of prosthetic materials and prosthetic design on the outcomes.MethodsElectronic and manual searches were performed to identify randomized‐, prospective‐, and retrospective clinical trials with follow‐up time of ≥12 months, evaluating the clinical outcomes of posterior iFDPs with pontic or iSpCs. Survival and complication rates were analyzed using robust Poisson's regression models.ResultsThirty‐two studies reporting on 42 study arms were included in the present systematic review. The meta‐analysis of the included studies indicated estimated 3‐year survival rates of 98.3% (95%CI: 95.6–99.3%) for porcelain‐fused‐to‐metal (PFM) iFDPs, 97.5% (95%CI: 95.5–98.7%) for veneered zirconia (Zr) iFDPs with pontic, 98.9% (95%CI: 96.8–99.6%) for monolithic or micro‐veneered zirconia iFDPs with pontic, and 97.0% (95%CI: 84.8–99.9%) for lithium disilicate iFDPs with pontics. The survival rates for different material combination showed no statistically significant differences. Veneered restorations, overall, showed significantly (p < .01) higher ceramic fracture and chipping rates compared with monolithic restorations. Furthermore, there was no significant difference in survival rates (98.3% [95%CI: 95.6–99.3%] vs. 99.1% [95%CI: 97.6–99.7%]) and overall complication rates between PFM iFDPs with pontic and PFM iSpCs.ConclusionsBased on the data identified by this systematic review, PFM, veneered Zr, and monolithic Zr iFDPs with pontic and iSpCs showed similarly high short‐term survival rates in the posterior area. Veneered restorations exhibit ceramic chipping more often than monolithic restorations, with the highest fracture rate reported for veneered Zr iFDPs.
Group 5 ITI Consensus Report: Implant placement and loading protocols
Authors: Morton Dean , Wismeijer Daniel , Chen Stephen , Hamilton Adam , Wittneben Julia , Casentini Paolo , Gonzaga Luiz , Lazarin Rafael , Martin William , Molinero‐Mourelle Pedro , Obermailer Barbara , Polido Waldemar D. , Tahmaseb Ali , Thoma Daniel , Zembic Anja 
Published: September 2023

AbstractObjectivesWorking Group 5 was convened to discuss and find consensus on the topics of implant placement and loading protocols associated with single missing teeth in the anterior maxilla (aesthetic zone). Consensus statements, clinical recommendations, patient perspectives and future research suggestions were developed and presented to the plenary for discussion and approval.Materials and MethodsTwo systematic reviews were developed and submitted prior to the conference. The group considered in detail the systematic reviews and developed statements, clinical recommendations, patient perspectives and future research suggestions based on the findings of the reviews and experience of group members. Definitive versions were developed after presentation to and discussion by the plenary.ResultsFive consensus statements were developed and approved from each systematic review. Twelve clinical recommendations were developed by the group based on both reviews and experience. Three patient perspectives were developed, and five suggestions made for future research.ConclusionsBased on the findings of the systematic reviews and experience of group members, the Type 1A protocol (immediate placement and immediate loading), when utilized in the anterior maxilla under favorable conditions, is considered predictable and is associated with high survival rates. The procedure is considered clinically viable and is associated with aesthetic outcomes, although surgical, technical, and biological complications can occur.
Do soft tissue augmentation techniques provide stable and favorable peri‐implant conditions in the medium and long term? A systematic review
Authors: Stefanini Martina , Barootchi Shayan , Sangiorgi Matteo , Pispero Alberto , Grusovin Maria Gabriella , Mancini Leonardo , Zucchelli Giovanni , Tavelli Lorenzo 
Published: September 2023

AbstractObjectivesTo review the available literature on the medium‐ and long‐term effects of soft tissue augmentation (STA) at implant sites and to explore the effects of the different approaches on clinical‐, patient‐reported, and health‐related parameters.Materials and MethodsA comprehensive electronic and manual search was performed to identify prospective clinical studies that assessed the medium‐ and long‐term (≥36 months) outcomes following STA, including number of sites maintaining peri‐implant health and number of sites developing peri‐implant disease, incidence of complications, stability of the clinical, volumetric, and radiographic parameters, and patient‐reported outcome measures (PROMs).ResultsFifteen studies were included in the qualitative analysis. STA was performed with either a bilaminar‐ or an apically positioned flap (APF) approach, in combination with autogenous grafts (free gingival graft [FGG] and connective tissue graft [CTG]) or substitutes (acellular dermal matrix [ADM] and xenogeneic cross‐linked collagen matrix [CCM]). An overall high survival rate was observed. Most of the augmented implant sites maintained peri‐implant health in the medium and long term, with the incidence of peri‐implant mucositis and peri‐implantitis ranging from 0% to 50% and from 0% to 7.14%, respectively. The position of the soft tissue margin following APF + FGG and bilaminar approaches involving CTG or CCM was found to be stable over time. No substantial changes were reported for plaque score/index, bleeding on probing/bleeding index, and probing depth between early time points and following visits. CTG‐based STA procedures resulted in a stable or increased dimension of keratinized mucosa width (KMW) and mucosal thickness (MT)/volumetric outcomes over time, when compared with early follow‐ups. Most of the included studies described stable marginal bone levels at the grafted implant sites over time. No substantial changes for patient‐reported outcomes and professionally assessed esthetic results were reported at different time points.ConclusionsImplants that received STA showed overall high survival rate and relatively low incidence of peri‐implantitis in the medium and long term. Augmented sites seem to maintain the level of soft tissue margin and marginal bone over time, while non‐augmented implants may exhibit apical shift of the soft tissue margin. The overall favorable early outcomes obtained with STA are maintained in the medium and long term, with an increase in KMW and MT that may be expected over time at CTG‐augmented sites.
Group 1 ITI Consensus Report: The role of bone dimensions and soft tissue augmentation procedures on the stability of clinical, radiographic, and patient‐reported outcomes of implant treatment
Authors: Jensen Simon S. , Aghaloo Tara , Jung Ronald E. , Bertl Kristina , Buser Daniel , Chappuis Vivianne , de Stavola Luca , Monje Alberto , Pispero Alberto , Roccuzzo Andrea , Shahdad Shakeel , Stefanini Martina , Tavelli Lorenzo , Wang Hom‐Lay , Zucchelli Giovanni 
Published: September 2023

AbstractObjectivesThe aims of Working Group 1 were to address the role (i) of the buccolingual bone dimensions after implant placement in healed alveolar ridge sites on the occurrence of biologic and aesthetic complications, and (ii) of soft tissue augmentation (STA) on the stability of clinical, radiographic, and patient‐related outcomes of implant treatments.Materials and MethodsTwo systematic reviews were prepared in advance of the Consensus Conference and were discussed among the participants of Group 1. Consensus statements, clinical recommendations, recommendations for future research, and reflections on patient perspectives were based on structured group discussions until consensus was reached among the entire group of experts. The statements were then presented and accepted following further discussion and modifications as required by the plenary.ResultsDimensional changes of the alveolar ridge occurred after implant placement in healed sites, and a reduction in buccal bone wall thickness (BBW) of 0.3 to 1.8 mm was observed. In healed sites with a BBW of <1.5 mm after implant placement, increased vertical bone loss, and less favorable clinical and radiographic outcomes were demonstrated. Implants with buccal dehiscence defects undergoing simultaneous guided bone regeneration, showed less vertical bone loss, and more favorable clinical and radiographic outcomes, compared to non‐augmented dehiscence defects during initial healing.At healthy single implant sites, probing depths, bleeding and plaque scores, and interproximal bone levels evaluated at 1 year, remained stable for up to 5 years, with or without STA. When single implant sites were augmented with connective tissue grafts, either for soft tissue phenotype modification or buccal soft tissue dehiscence, stable levels of the soft tissue margin, and stable or even increased soft tissue thickness and/or width of keratinized mucosa could be observed from 1 to 5 years. In contrast, non‐augmented sites were more prone to show apical migration of the soft tissue margin in the long‐term. Favorable aesthetic and patient‐reported outcomes after STA were documented to be stable from 1 to 5 years.ConclusionsIt is concluded that dimensional changes of the alveolar ridge occur after implant placement in healed sites and that sites with a thin BBW after implant placement are prone to exhibit less favorable clinical and radiographic outcomes. In addition, it is concluded that STA can provide stable clinical, radiographic, aesthetic, and patient‐reported outcomes in the medium and long‐term.