bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biocatalysis of triglycerides transesterification using fungal biomass: a biorefinery approach
Authors: Elhussiny Nadeem I. , Mohamed Ahmed M. A. , El-Refai Heba A. , Mohamed Sayeda S. , Shetaia Yousseria M. , Amin Hala A. , Klöck Gerd 
Published: June 2023

Abstract
Background
The use of microbial biomasses, such as fungal biomass, to catalyze the transesterification of triglycerides (TG) for biodiesel production provides a sustainable, economical alternative while still having the main advantages of expensive immobilized enzymes.

Results
Biomasses of Aspergillus flavus and Rhizopus stolonifera were used to catalyze the transesterification of TG in waste frying oil (WFO). Isopropanol as an acyl-acceptor reduced the catalytic capability of the biomasses, while methanol was the most potent acyl-acceptor with a final fatty acid methyl ester (FAME) concentration of 85.5 and 89.7%, w/w, for R. stolonifer and A. flavus, respectively. Different mixtures of the fungal biomasses were tested, and higher proportions of A. flavus biomass improved the mixture's catalytic capability. C. sorokiniana cultivated in synthetic wastewater was used as feedstock to cultivate A. flavus. The biomass produced had the same catalytic capability as the biomass produced in the control culture medium. Response surface methodology (RSM) was adopted using central composite design (CCD) to optimize the A. flavus biomass catalytic transesterification reaction, where temperature, methanol concentration, and biomass concentration were selected for optimization. The significance of the model was verified, and the suggested optimum reaction conditions were 25.5 °C, 250 RPM agitation with 14%, w/w, biomass, 3 mol/L methanol, and a reaction duration of 24 h. The suggested optimum conditions were tested to validate the model and a final FAME concentration of 95.53%. w/w was detected.

Conclusion
Biomasses cocktails might be a legitimate possibility to provide a cheaper technical solution for industrial applications than immobilized enzymes. The use of fungal biomass cultivated on the microalgae recovered from wastewater treatment for the catalysis of transesterification reaction provides an additional piece of the puzzle of biorefinery. Optimizing the transesterification reaction led to a valid prediction model with a final FAME concentration of 95.53%, w/w.
Mixed neuroendocrine–non-neuroendocrine neoplasm of the ampulla of Vater: a case report
Authors: Date Kenjiro , Tatsuguchi Takaaki , Shimokawa Yuzo , Niina Yusuke , Kitahara Daichi , Kuga Hirotaka , Tamiya Sadafumi , Nishihara Kazuyoshi , Nakano Toru 
Published: June 2023

Abstract
Background
Mixed neuroendocrine–non-neuroendocrine neoplasms of the ampulla of Vater are rare and heterogenous, making it difficult to achieve a definitive preoperative diagnosis. Herein, we describe a patient in whom a provisional diagnosis of mixed neuroendocrine–non-neuroendocrine neoplasm of the ampulla of Vater was made preoperatively.

Case presentation
Computed tomography revealed an enhancing periampullary tumor in a 69-year-old man with obstructive jaundice. Subsequent duodenoscopy revealed an ulcerated lesion in the swollen ampulla of Vater, from which six biopsies were collected. Pathological examination revealed adenocarcinoma in five of them. The remaining one was a neuroendocrine neoplasm according to immunohistochemical analysis. With a provisional diagnosis of mixed neuroendocrine–non-neuroendocrine neoplasm of the ampulla of Vater, the patient underwent subtotal stomach-preserving pancreaticoduodenectomy with modified Child’s reconstruction and was discharged without complications. Pathological examination revealed both adenocarcinoma and neuroendocrine carcinomas, each accounting for ≥ 30% of the tumor, resulting in a definitive diagnosis of mixed neuroendocrine–non-neuroendocrine neoplasm of the ampulla of Vater. Lymph node metastases with neuroendocrine components were also observed. Adjuvant chemotherapy was not administered because of the patient’s renal dysfunction. Liver and lymph node metastases were detected 2 months after surgery, the neuroendocrine component being considered responsible for that relapse. The patient underwent platinum-based chemotherapy at 50% dosage, which initially resulted in significant tumor shrinkage; however, he died 6 months after surgery.

Conclusions
While these tumors’ heterogeneity make definitive preoperative diagnosis of mixed neuroendocrine–non-neuroendocrine neoplasm of the ampulla of Vater difficult, the possibility of this disease can be considered by careful examination. Further study is needed to establish the optimal diagnostic criteria and treatment strategy.
A case of safe airway management by fiber-optic nasotracheal intubation in general anesthesia in a pediatric patient with Hajdu-Cheney syndrome: a case report
Authors: Kokita Atsushi , Chaki Tomohiro , Yamakage Michiaki 
Published: June 2023

Abstract
Background
Hajdu-Cheney syndrome (HCS) is an extremely rare disorder characterized by progressive acro-osteolysis. A unique facial structure and deformity of the cervical spine are associated with a difficult airway. Although several reports describe general anesthesia with orotracheal intubation for patients with HCS, there have been no reports of nasotracheal intubation with a risk of skull base fracture. We describe nasotracheal intubation for oral surgery in a patient with HCS.

Case presentation
A 13-year-old girl with HCS was scheduled for dental surgery. Preoperative computed tomography revealed no abnormalities including fractures in the skull base or cervical spine. After confirming a lack of vocal cord paralysis by bronchofiberscopic inspection from the nose, general anesthesia was induced with sevoflurane, remifentanil, and rocuronium. Fiber-optic nasotracheal intubation was successfully performed without complications such as depletion of oxygen saturation and massive epistaxis, and the surgery was completed uneventfully. She was discharged the day after surgery with no anesthesia-related complications.

Conclusions
We were able to safely manage the airway of a patient with HCS by nasotracheal intubation under general anesthesia.
The understanding of medical undergraduates and interns towards basic life support: a cross-sectional study
Authors: Sharma Ankur , Goyal Shilpa , Singh Nehal C. , Kothari Nikhil , Bhatia Pradeep 
Published: June 2023

Abstract
Background
The aim of this study is to understand the attitude and knowledge of medical undergraduates and interns for basic life support (BLS) measures. We also correlated the need for frequent orientation courses beginning at an earlier stage of the medical curriculum. This cross-sectional study was done based on the questionnaire relating to attitude and knowledge for BLS. The participants were 7th and 9th-semester medical undergraduates and the interns of a tertiary care center.

Results
A total of 213 participants completed the questionnaire. The majority of them were interns (40.37%). Maximum (94.1%) of the participants opined that the entire medical and nursing fraternity should be exposed to simulation-based training on BLS. Most (80.3%) of them were aware of recent American Heart Association guidelines 2020, and 96.7% knew the correct meaning of cardiopulmonary resuscitation, but they did not know the subsequent steps in BLS according to the guidelines.

Conclusions
We conclude that awareness of BLS lacked in students of medical school despite regular orientation programs. We recommend the need for frequent orientation courses for BLS and initiate them at the elementary level of education.
Intensive care unit length of stay and mortality comparison between on-pump and off-pump coronary artery bypass graft: a retrospective study
Authors: Ibrahim Rita Zahara , Joyo Ericko Ongko 
Published: June 2023

Abstract
Background
Recently, coronary artery bypass graft (CABG) techniques, both on-pump (ONCABG) and off-pump (OPCABG), were compared to seek the most effective approach to reduce the cost of prolonged intensive care unit length of stay (ICU LOS) and mortality. This study aims to compare ICU LOS and mortality in ONCABG and OPCABG.

Results
Demographic data of 1569 patients show the variance of characteristics. The analysis shows significant and longer ICU LOS in OPCABG than ONCABG (2.151 ± 0.100 vs. 1.573 ± 0.246 days; p = 0.028). Similar results were demonstrated after adjustment of covariates effects (3.146 ± 0.281 vs. 2.548 ± 0.245 days; p = 0,022). Logistic regression shows no significant difference in mortality in OPCABG and ONCABG, both in the unadjusted (OR [CI 95%] 1.133 [0.485–2.800]; p = 0.733) and the adjusted models (OR [CI 95%] 1.133 [0.482–2.817]; p = 0,735).

Conclusion
ICU LOS was significantly longer in OPCABG patients than in ONCABG patients in the author's centre. There was no significant difference in mortality between the two groups. This finding highlights a discrepancy between recently published theories and the practices observed in the author's centre.
First-Line, Fixed-Duration Nivolumab Plus Ipilimumab Followed by Nivolumab in Clinically Diverse Patient Populations With Unresectable Stage III or IV Melanoma: CheckMate 401
Authors: Dummer Reinhard , Corrie Pippa , Gutzmer Ralf , Meniawy Tarek M. , Del Vecchio Michele , Lebbé Céleste , Guida Michele , Dutriaux Caroline , Dreno Brigitte , Meyer Nicolas , Ferrucci Pier Francesco , Dalle Stéphane , Khattak Muhammad Adnan , Grob Jean-Jacques , Briscoe Karen , Larkin James , Mansard Sandrine , Lesimple Thierry , Guidoboni Massimo , Sabatini Silvia , Richtig Erika , Herbst Rudolf , Lobo Maurice , Askelson Margarita , Ascierto Paolo A. , Maio Michele 
Published: June 2023

PURPOSE To address the paucity of data in patients with historically poor outcomes, we conducted the single-arm phase IIIb CheckMate 401 study to evaluate the safety and efficacy of nivolumab plus ipilimumab followed by nivolumab monotherapy in clinically diverse patient populations with advanced melanoma. METHODS Treatment-naive patients with unresectable stage III-IV melanoma received nivolumab 1 mg/kg plus ipilimumab 3 mg/kg once every 3 weeks (four doses) followed by nivolumab 3 mg/kg (240 mg following a protocol amendment) once every 2 weeks for ≤24 months. The primary end point was the incidence of grade 3-5 select treatment-related adverse events (TRAEs). Overall survival (OS) was a secondary end point. Outcomes were evaluated in subgroups defined by Eastern Cooperative Oncology Group performance status (ECOG PS), brain metastasis status, and melanoma subtype. RESULTS In total, 533 patients received at least one dose of study drug. Grade 3-5 select TRAEs affecting the GI (16%), hepatic (15%), endocrine (11%), skin (7%), renal (2%), and pulmonary (1%) systems occurred in the all-treated population; similar incidence rates were observed across all subgroups. At 21.6 months' median follow-up, 24-month OS rates were 63% in the all-treated population, 44% in the ECOG PS 2 subgroup (including patients with cutaneous melanoma only), 71% in the brain metastasis subgroup, 36% in the ocular/uveal melanoma subgroup, and 38% in the mucosal melanoma subgroup. CONCLUSION Nivolumab plus ipilimumab followed by nivolumab monotherapy was tolerable in patients with advanced melanoma and poor prognostic characteristics. Efficacy was similar between the all-treated population and patients with brain metastases. Reduced efficacy was observed in patients with ECOG PS 2, ocular/uveal melanoma, and/or mucosal melanoma, highlighting the continued need for novel treatment options for these difficult-to-treat patients.
Intimate Foreign Relations
Authors: Litvin Margaret 
Published: June 2023

AbstractVisualizing Soviet internationalism as a student dormitory, this essay identifies a new transnational subgenre, the Soviet dormitory novel, and analyzes four examples: Nazim Hikmet’s Life’s Good, Brother (Turkish, 1964); Ismail Kadare’s Twilight of the Eastern Gods (Albanian, 1978); Sonallah Ibrahim’s Ice (Arabic, 2011); and Yurii Andrukhovych’s Moscoviad (Ukrainian, 2000). These works each depict a different decade and come from different locations on the concentric map of Soviet influence: the Afro-Asian world, Eastern Europe, and the non-Russian USSR. Together, they reveal some shared formal features of the dormitory novel and some unintended consequences of Soviet internationalism, including the various racisms it rejected but helped perpetuate.
The Rise of Dutch Neo-Calvinist Political Economy, 1830–1905
Authors: Hengstmengel Joost 
Published: June 2023

AbstractThe years 1904–5 seemed to mark the birth of neo-Calvinist political economy in the Netherlands. It was then that three jurists affiliated with the Free University of Amsterdam, an institution founded by the theologian Abraham Kuyper, published their first economic writings. This article deals with the rise of neo-Calvinist political economy, which mirrored the emergence of Catholic economic thought that took place in precisely the same period, and seeks to explain where the ideal of this religious approach to economics came from. It describes the awakening of a socioeconomic commitment in Dutch Réveil circles, the influence of Thomas Chalmers's Christian political economy on the antirevolutionary statesman Guillaume Groen van Prinsterer, and the place of economics in Kuyper's neo-Calvinist worldview. It is shown that Groen van Prinsterer's desire to infuse economic science with biblical views was eventually replaced by Kuyper's vision of formulating a full-fledged Calvinist alternative to mainstream economics. Despite some attempts at Calvinist political economy at the dawn of the nineteenth century, this project never really got off the ground.
Aesthetic Historicism Now
Authors: Sussman Matthew 
Published: June 2023

Abstract
This essay traces the concept of “aesthetic historicism” in literary studies, from its first appearance in the writing of Erich Auerbach to its influence on an array of contemporary currents loosely associated with “new formalism,” such as historical formalism, historical poetics, and historical stylistics. It argues that while Auerbachian aesthetic historicism played a key role in relativizing standards of aesthetic judgment—and thus arguing against aesthetic universals—a newly invigorated version would conceive the history of criticism as a chronicle of different formalisms, each contributing to the construction of “the aesthetic” across time and space.
George Gissing Goes Out in Style: The Syntax of Class after 1890
Authors: Millen Alexander 
Published: June 2023

Abstract
Literary historians often cite George Gissing’s New Grub Street (1891) as a chronicle of a waning literary scene, but his sentences offer altogether stranger demonstrations of how a threatened form of realism attempts to grasp a radically transformed and transforming social situation. Drawing on recent work on the politics of style, this essay argues that Gissing’s narrative style is best understood in terms of two motivating forces powerfully at work in late nineteenth-century Britain: an ascendant popular culture and the massive expansion of the imperial regime. By focusing less on the rumble and verve of an incipient modernism than on the creaky cadences of a realism not long for the world, we begin to discern tectonic shifts at the level of the sentence within and beyond Gissing’s late novels (and the triple-decker). Such shifts allow us to understand how the residual realism of nineteenth-century social-problem fiction attempts to map the world-system. A discussion of Gissing’s style is thus an opportunity to specify the motivating forces at work in his writing and to speculate more broadly about how novelistic prose registers working-class massification and the internationalization of British economic and social worlds in the late nineteenth century.
Vestibular Schwannoma Stereotactic Radiosurgery in Octogenarians: Case Series
Authors: Head Jeffery R. , Bin-Alamer Othman , Wei Zhishuo , Waite Kaitlin , Agrawal Nishant , Mallela Arka N. , Faramand Andrew , Gersey Zachary C. , Niranjan Ajay , Lunsford L. Dade , Abou-Al-Shaar Hussam 
Published: June 2023

BACKGROUND AND OBJECTIVES:The management of octogenarians with vestibular schwannomas (VS) has received little attention. However, with the increase in octogenarian population, more effort is needed to clarify the value of stereotactic radiosurgery (SRS) in this population. The aim of this study was to evaluate the safety and efficacy of SRS in this patient age group.METHODS:A retrospective study of 62 patients aged 80 years or older who underwent single-session SRS for symptomatic VS during a 35-year interval was performed. The median patient age was 82 years, and 61.3% were male. SRS was performed as planned adjuvant management or for delayed progression after prior partial resection in 5 patients.RESULTS:SRS resulted in a 5-year tumor control rate of 95.6% with a 4.8% risk of adverse radiation effects (ARE). Tumor control was unrelated to patient age, tumor volume, Koos grade, sex, SRS margin dose, or prior surgical management. Four patients underwent additional management including 1 patient with symptomatic progression requiring surgical resection, 2 patients with symptomatic hydrocephalus requiring cerebrospinal fluid diversion, and 1 patient whose tumor-related cyst required delayed cyst aspiration. Three patients developed ARE, including 1 patient with permanent facial weakness (House-Brackmann grade II), 1 who developed trigeminal neuropathy, and 1 who had worsening gait disorder. Six patients had serviceable hearing preservation before SRS, and 2 maintained serviceable hearing preservation after 4 years. A total of 44 (71%) patients died at an interval ranging from 6 to 244 months after SRS.CONCLUSION:SRS resulted in tumor and symptom control in most octogenarian patients with VS.
Contemporary Trends in Minimally Invasive Sacroiliac Joint Fusion Utilization in the Medicare Population by Specialty
Authors: Hersh Andrew M. , Jimenez Adrian E. , Pellot Karolina I. , Gong Jung Ho , Jiang Kelly , Khalifeh Jawad M. , Ahmed A. Karim , Raad Micheal , Veeravagu Anand , Ratliff John K. , Jain Amit , Lubelski Daniel , Bydon Ali , Witham Timothy F. , Theodore Nicholas , Azad Tej D. 
Published: June 2023

BACKGROUND AND OBJECTIVES:
Sacroiliac (SI) joint dysfunction constitutes a leading cause of pain and disability. Although surgical arthrodesis is traditionally performed under open approaches, the past decade has seen a rise in minimally invasive surgical (MIS) techniques and new federally approved devices for MIS approaches. In addition to neurosurgeons and orthopedic surgeons, proceduralists from nonsurgical specialties are performing MIS procedures for SI pathology. Here, we analyze trends in SI joint fusions performed by different provider groups, along with trends in the charges billed and reimbursement provided by Medicare.

METHODS:
We review yearly Physician/Supplier Procedure Summary data from 2015 to 2020 from the Centers for Medicare and Medicaid Services for all SI joint fusions. Patients were stratified as undergoing MIS or open procedures. Utilization was adjusted per million Medicare beneficiaries and weighted averages for charges and reimbursements were calculated, controlling for inflation. Reimbursement-to-charge (RCR) ratios were calculated, reflecting the proportion of provider billed amounts reimbursed by Medicare.

RESULTS:
A total of 12 978 SI joint fusion procedures were performed, with the majority (76.5%) being MIS procedures. Most MIS procedures were performed by nonsurgical specialists (52.1%) while most open fusions were performed by spine surgeons (71%). Rapid growth in MIS procedures was noted for all specialty categories, along with an increased number of procedures offered in the outpatient setting and ambulatory surgical centers. The overall RCR increased over time and was ultimately similar between spine surgeons (RCR = 0.26) and nonsurgeon specialists (RCR = 0.27) performing MIS procedures.

CONCLUSION:
Substantial growth in MIS procedures for SI pathology has occurred in recent years in the Medicare population. This growth can largely be attributed to adoption by nonsurgical specialists, whose reimbursement and RCR increased for MIS procedures. Future studies are warranted to better understand the impact of these trends on patient outcomes and costs.
Etiology and Prevention of Common Injuries in Golf
Authors: Hasley Ike B. , Ostby Timothy D. , Fjosne Christopher M. , Jelsing Elena J. 
Published: June 2023

AbstractGolf is a popular sport played by individuals of varying age and skillsets. The golf swing is unique and complex, creating potential for various musculoskeletal injuries in both amateur and professional golfers. Understanding the basic biomechanics of the golf swing and its relation to injury etiology can assist the health care provider in recognizing and preventing musculoskeletal injuries secondary to golf. Most injuries occur in the upper limb and the lumbar spine. This review describes musculoskeletal pathologies seen in golfers with respect to anatomic area and golf swing biomechanics, while summarizing effective prevention strategies and swing modifications to address these potential injuries.
Book-tax conformity and earnings management: recent research
Authors: Floropoulos Stylianos , Tsipouridou Maria , Spathis Charalambos 
Published: June 2023

Corporations use two different sets of financial statements which have mirror-image goals, firms want to maximize book income reported to investors, while minimizing the taxable income reported to the tax authorities. The dual nature of corporate profit reporting may be creating a lose-lose situation, less meaningful profit numbers for capital markets and lowered corporate tax revenue for the government. Defenders of the book-tax divide argue that a unified system cannot accommodate these differing objectives, while supporters of the book-tax conformity claim that a tax-based book income can restore the integrity of the financial accounting system. The study reviews the arguments of high vs. low book-tax conformity. It also reviews prior research that examines the association between book-tax conformity and earnings management.

JEL Classification: H2, M4, M40, M41
Key words: book-tax conformity, earnings management, book income, tax income, tax incentives
The Impact of Subjectivity on Financial Accounting
Authors: Papadeas Panagiotis 
Published: June 2023

In this paper it is attempted to explore current trends in Financial Accounting, that connect research endeavors in the relatively new branch of Behavioral Finance, with the impact of subjectivity on the accounting cycle of each fiscal year, as well as on the preparation of financial statements.
The investigation of subjective factors in Financial Accounting expands its scope, while the systematic utilization of its two-way relationship with the field of Neurofinance (unbiased data) may create a broader framework of knowledge for the further improvement of the investment process, through an understanding of the methodology required by accounting operations and rules up until the preparation of financial statements. By extension, a better understanding of how financial markets operate will be beneficial not only for governments wishing to promote savings incentives and responsible management, but also for supervisory authorities seeking to ensure that the market for personal financial services operates rationally and without bias.

Keywords: Behavioral Finance, Neurofinance, Financial Accounting
JEL Classification: D87, G41, M41