bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced computerized cognitive remediation therapy improved cognitive function, negative symptoms, and GDNF in male long-term inpatients with schizophrenia
Authors: Zhang Peiyun , Chen Lingyun , Qin Qianqian , Liu Chao , Zhu Haijiao , Hu Wenqing , He Xinyu , Tang Kaihong , Yan Qi , Shen Hongmei 
Published: January 2025

ObjectiveNegative and cognitive symptoms present significant challenges in patients with schizophrenia, and cognitive remediation is a promising approach to alleviate these symptoms. This study aimed to explore the efficacy of computerized cognitive remediation therapy (CCRT) on psychiatric symptoms, cognitive deficits, and serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in patients with schizophrenia.Materials and methodsForty male long-term institutionalized inpatients with schizophrenia were assigned to either a CCRT group (n = 20) or a control group (n = 20). The CCRT intervention consisted of 40 individual 40-min sessions over 8 weeks, conducted five times a week. Psychiatric symptoms, cognition, and serum levels of BDNF and GDNF were assessed at baseline, 4 weeks, and 8 weeks.ResultsCompared to the control group, the CCRT group exhibited decreased total Positive and Negative Syndrome Scale and negative subscale scores, as well as increased Montreal Cognitive Assessment and Repeatable Battery for the Assessment of Neuropsychological Status scores. Moreover, improvements in list recall were associated with reduced negative symptoms. Additionally, CCRT ameliorated the decrease in serum GDNF levels in patients with schizophrenia.ConclusionThe effectiveness of CCRT in alleviating negative symptoms was associated with improvements in list recall, and GDNF may play a role in the observed effects of CCRT in patients with schizophrenia.
Relação entre o antímero de preferência para apresentação facial e a auto percepção de ações de dominância corporal
Authors: Trevizan Bianca Honório , Júnior Roberto Bernardino 
Published: January 2025

Na odontologia existem áreas como oclusão e harmonização facial para as quais medidas bilaterais e equilíbrio entre estruturas faciais são essenciais para questões estéticas e funcionais. Comumente, na obtenção de imagens (fotografias) os indivíduos apresentam um lado de preferência para serem registradas os quais podem ter relação com os antímeros dominantes de olho, mastigação e membros superiores (braço). Nesse sentido, para o profissional é fundamental que o paciente tenha clareza e entendimento daquilo que o incomoda, além de conseguir informar ao cirurgião dentista. Dessa forma, ambos terão resultados positivos. Com isso, esse trabalho tem como objetivo identificar uma possível correlação entre o antímero de preferência para coleta de imagens, o de dominância mastigatória informada, o de dominância visual e o de dominância do membro superior, em voluntários que transitaram pelas ruas do bairro Umuarama, Uberlândia-MG. Essas informações foram registradas em um questionário com perguntas estruturadas. Caso, sobre o antímero dominante ocular e mastigatório houvesse dúvida, seria disponibilizado papel com orifício para visão e chiclete para mastigação. Através dos resultados tabelados foi possível ter dados que correlacionem tais parâmetros e assim podendo ter um padrão, sendo que as mulheres preferem o lado esquerdo da face para evidenciar e suas dominâncias de forma contrária sendo o lado direito, já os homens possuem em tudo o lado direito, no qual auxiliaria a ação do profissional na harmonização facial e oclusão. Para análise estatística será utilizado o teste exato de Fisher com p<0,05 e descrição de porcentagem. Constata-se assim que há uma influência neurocomportamental entre as dominâncias e preferência.
Entornos virtuales de aprendizajes: Contribuciones teóricas para las instituciones educativas de Maicao, Colombia
Authors: Perea-García Jaime Eliécer 
Published: January 2025

Los Entornos Virtuales de Aprendizaje (EVA) significan una oportunidad para desarrollar conocimientos, habilidades, destrezas y competencias a las cuales no se tenía acceso en tiempos anteriores, aunque su implementación efectiva demanda altos desafíos en terminos de conocimiento y práctica para las propias instituciones educativas. Considerando esta idea, se presenta este articulo enmarcado en exponer argumentos teóricos, conceptuales y pedagógicos sustentadores del aprendizaje en entornos virtuales, que podrían ser de consideración para las instituciones educativas de Maicao. El mismo es una investigación documental, orientada metodologicamente mediante un diseño bibliografico. Como resultado, se puede enunciar que Los EVA se constituyen en herramientas poderosa para enriquecer el proceso educativo, haciéndolo flexible, innovador, dinámico e interactivo. Sin embargo, su efectividad pende de que las herramientas y recursos tecnológicos se integren adecuadamente con el diseño pedagógico que sustenta al EVA.
Características de la invasión al sistema nervioso central en leucemia linfoblástica aguda. Experiencia de cinco años en dos centros de Ciudad de México
Authors: Ramos Peñafiel Christian Omar , Pérez Sámano Daniela , Olarte Carrillo Irma , Gallardo Rodríguez Adán Germán , Cerón Maldonado Rafael , Martínez Tovar Adolfo 
Published: January 2025

Introducción. La invasión o infiltración al sistema nervioso central (SNC) puede presentarse tanto en el diagnóstico como en el seguimiento. Factores como la hiperleucocitosis, fenotipo T, t (1;19) o punciones traumáticas aumentan el riesgo. Los resultados con tratamiento intratecal son variables y requieren la combinación de quimioterapia sistémica o radioterapia. La asociación con infiltración de la médula ósea empeora el pronóstico.
Objetivos. En este estudio se describen las características de los casos con leucemia linfoblástica aguda (LLA) e infiltración del SNC en pacientes atendidos en dos centros de referencia en México.
Métodos. Estudio observacional, descriptivo, retrospectivo, en pacientes adultos con LLA e infiltración del SNC en el diagnóstico o durante el seguimiento, detectada por citomorfología o por citometría de flujo.
Resultados. Se estudiaron 30 pacientes, 73,3 % fueron hombres, la media de edad fue 29 años (17 a 57 años). El 86,7 % (n=26) correspondieron a pacientes con un riesgo alto de recaída y mayormente con fenotipo B (93,3 %). En el 70,0 % de los casos el diagnóstico se realizó por citomorfología y en el 26,7 %, por citometría de flujo; el síntoma principal fue cefalea (56,7 %) y el 10,0 % cursaron con alguna neuropatía periférica. El tiempo promedio para recaída fue de 417 días, el 66,7 % (n=20) logró una respuesta favorable a quimioterapia intratecal intensiva dos veces por semana. Un 33,3 % (n=10) ameritó la combinación con otras estrategias. La infiltración del SNC en un periodo menor de 400 días se asoció con un peor pronóstico.
Conclusión. La infiltración al SNC es una complicación esperada que requiere una rápida resolución para prevenir la recaída en la médula ósea.
Incidencia de la enfermedad injerto contra huésped aguda en los pacientes con trasplante alogénico de progenitores hematopoyéticos de donante HLA idéntico intrafamiliar en un centro hospitalario
Authors: Guarín Castañeda Angie Paola , Mora Figueroa Gloria Elena , Pedraza Mesa Enrique , Figueroa-Camacho Javier Leonardo , Peña Ardila Oscar Javier , López Mora María José , Pinzón leal Paula Lucía , Lamadrid Sastre Cesar Augusto , López Castañeda Gustavo Adolfo , Villamizar Gómez Francy Licet , Gómez Calcetero Carlos Fernando , Gómez Ortiz Mauricio Efrain , Ardila Robles Sergio Felipe , Esguerra Herman 
Published: January 2025

Objetivo: Una de las complicaciones del trasplante alogénico de precursores hematopoyéticos es la enfermedad injerto contra huésped aguda (EICHa). El objetivo de este estudio es describir su incidencia y factores de riesgo en una cohorte de pacientes adultos receptores de trasplante alogénico de progenitores hematopoyéticos de donante HLA idéntico intrafamiliar (Alo-TPH DFI, por sus siglas en inglés).
Métodos: Se realizó un estudio de cohorte descriptiva histórica que incluyó pacientes que recibieron Alo-TPH DFI entre 2015 y 2018 en un centro médico de Bogotá, Colombia.
Resultados: El 59,79 % (n=58) de los pacientes manifestó EICHa. En el análisis de regresión de Cox, univariado y multivariado, el sexo femenino del donante se presentó como un factor pronóstico con diferencias estadísticas significativas (p=0,0400 y p=0,0040, respectivamente). Se evidenciaron como predictores independientes de la EICHa al año del trasplante el acondicionamiento mieloablativo (HR=2,43, p=0,0230), la profilaxis que no incluyera ciclofosfamida (HR=2,48, p=0,0290) y la edad del donante (HR=1,02, p=0,0200). Sobre la supervivencia libre de recaída al año, se halló diferencia entre los pacientes con EICHa y sin EICHa con 90,51 % y 63,94 %, respectivamente (p=0,0014). Así mismo, se encontró que los pacientes con EICHa GI-II tuvieron una supervivencia global (SG) del 85,71 %, mientras que en los pacientes con EICHa GIII-IV fue del 63,64 % (ꭓ2=0,0633).
Conclusiones: La incidencia de EICHa en este trabajo es similar a la encontrada en estudios previos. El desarrollo de EICHa disminuyó el riesgo de recaída e impacto en la supervivencia libre de progresión a un año, pero la mejoría en la SG se limitó a los pacientes con EICHa grados I y II.
BIMBINGAN SPIRITUAL PASIEN KANKER PAYUDARA DI RUMAH SAKIT
Authors: Mulidah Siti , Asrin Asrin , Sukrillah Ulfah Agus 
Published: January 2025

Latar belakang: Perawat kurang berperan dalam pemenuhan kebutuhan spiritual. pasien kanker payudara memerlukan bimbingan spiritual dalam menghadapi penyakit yang dideritanya. Tujuan: Penelitian ini bertujuan untuk bimbingan spiritual pada pasien kanker payudara di rumah sakit. Metode: Penelitian ini menggunakan desain penelitian diskriptif kuantitatif dengan pendekatan cross-sectional. Penelitian dilaksanakan di Rumah Sakit Umum Daerah Prof. Dr. Margono Soekarjo Purwokerto tahun 2023. Populasi pada penelitian ini adalah pasien kanker payudara yang berjumlah 30 responden. Data tingkat spiritual dan bimbingan spiritual diperoleh menggunakan kuesioner Spiritual Well-Being Scale (SWBS). Data penelitian dianalisis dengan menggunakan Wilcoxon Signed Rank Test dan Mann Whitney Test. Hasil: Mayoritas usia antara 45-54 tahun yaitu 33,0%, tingkat pendidikan dasar SLTP/sederajat 29,7% dan SD/sederajat 26,4%, kebanyakan ibu bekerja, pendapatan kurang sebesar 9,9%, kebanyakan menjalani kemoterapi < 12 bulan. Tingkat spiritualitas paling banyak sedang (57%). Tingkat kecemasan responden mayoritas sedang (50%) dan tinggi 30%. Ada hubungan antara tingkat spiritualiatas dengan tingkat kecemasan pasien kanker payudara di rumah sakit (p = 0.001). Bimbingan spiritual pasien kanker payudara di rumah sakit oleh perawat yang sudah dilakukan sebatas mengingatkan supaya menjalankan sholat dan berdoa/berzikir pada pagi hari. Kesimpulan: Pasien kanker payudara mengalami tingkat spiritual yang rendah dan mengalami kecemasan sehingga diperlukan bimbingan spiritual dalam memberikan pelayanan keperawatan.
LAND RIGHTS DISPUTE RESOLUTION PROCESS THROUGH MEDIATION AT PADANGSIDIMPUAN CITY LAND OFFICE
Authors: Busyro Marwan , Saifuddin Bandaharo 
Published: January 2025

This research aims to find out how the process of resolving land rights disputes through mediation is and what the obstacles to the process of resolving land rights disputes through mediation at the Land Office of Padangsidimpuan. This research uses an empirical juridical research method; that not only focuses on the positivity of legal aspects butis also concerned with its application or practice in the real field, in this case, the approach is used to qualitatively analyze the resolution of land rights disputes through mediation at the Land Office of Padangsidimpuan. Based on the results of the research and discussion, it was concluded that the procedures for resolving disputes carried out by the Land Office include stages (1) pre-mediation, and (2) mediation. In resolving land rights disputes at the Padangsidimpuan Land Office, there are several obstacles, namely (1) there are obstacles from the disputing parties, such as the absence of the parties to fulfill the invitation to mediate (2) there is no good faith from each party. (3) differences in ability and education between the parties (4) rules that are considered to slow down the dispute resolution process (5) complainants often do not know the requirements and procedures for dispute resolution at the Land Office of Padangsidimpuan.
Circadian Variability of Bioelectric Muscle Tone in Static and Dynamic Anaerobic Exercises in Men
Authors: Stawiarska Aleksandra , Chwała Wiesław , Gajdosz Ryszard , Gajdosz Anna 
Published: January 2025

Purpose
The aim of the study was to determine the circadian variability of bioelectric muscle tone in static and dynamic exercises with the use of surface electromyography (sEMG).
Methods
The research sample consisted of 16 men aged 21.6±0.62 years. The tests were conducted at 02:00,10:00,18:00,22:00, included measurements of bioelectric tension (sEMG) of the vastus lateralis muscle of the right and left limbs during maximum voluntary isometric contraction (MVC), the Jumping test—vertical jump with (CMJ) and without arm swing (ACMJ), a 10-second cycle ergometer test. The tests were repeated after 24 hours.
Results
The level of bioelectric tension recorded during MVC did not show significant circadian variability. However, in dynamic exercises, significant variability (p<0.05) in bioelectric tension of the muscle of the left limb during the CMJ was observed between 22:00 and 18:00. A tendency to achieve higher average amplitude values was observed at 10:00 in both limbs, with the lowest values observed at 02:00 am. After 24 hours, the highest bioelectric activity was observed in both limbs at 10:00 during the CMJ, while the lowest values in the left limb at 02:00. During the ACMJ, the lowest level of bioelectric activity in the right limb was observed at 02:00. In the 10-second anaerobic test, significant variability in bioelectric tension in the left limb was shown between 18:00 (highest) and 02:00 (lowest). After 24 hours, the measurement values were generally lower.
Conclusions
The highest sEMG biopotential amplitude values were recorded in the evening and afternoon, while the lowest values were recorded at night time.
Determination of the elongation forces of oesophageal tissue in uniaxial tensile test
Authors: Marcula Karol 
Published: January 2025

Purpose
The aim of this study was to determine the range of optimal tensile forces for the oesophageal tissue and to characterise the biomechanics of the oesophageal tissue.
Methods
The subjects of the study were oesophageal fragments of white Pekin ducks with a length of approximately 50 mm. Mechanical uniaxial tensile tests were carried out on fragments of the oesophagus and the effect of long-term tissue loading on the ability to permanently elongate was investigated. All measurements carried out were performed under laboratory conditions imitating the tissue environment.
Results
Force-elongation characteristics and stress-strain characteristics were determined from the experimental tests. The mean value of the ultimate tensile force in uniaxial tensile test was 45.32 ± 6.67 N. Mean ultimate tensile strain of 0.41 ± 0.02 and mean ultimate tensile stress of 2.04 ± 0.83 MPa were also determined. Tests carried out on the effect of a constant tensile force showed that the average value of permanent strain observed was 32.17 ± 2.26 %.
Conclusions
The conducted research allowed to characterise the biomechanics of white Pekin duck oesophageal tissue. The analyzed range of the elongation force provides satisfactory permanent tissue strain. Within the force range studied, no effect of the loading force value on the strain capacity of the oesophageal tissue was demonstrated.
Kontekstualisasi Al-Qur'an dalam Pendidikan Global
Authors: Latifah Milahtul , Fatchiatuzahro  
Published: January 2025

Globalisasi adalah sebuah fenomena yang telah mendominasi perubahan dunia dalam beberapa dekade terakhir. Teknologi informasi dan komunikasi, khususnya internet, telah memainkan peran besar dalam mempercepat globalisasi. Ini memungkinkan individu dan organisasi untuk berkomunikasi, berkolaborasi, dan berbagi informasi dengan cepat di seluruh dunia. Pendekatan ini mengunakan tafsir maudhu’i memahami bahwa teks Al-Qur'an tidak hanya bisa dilihat secara individual, tetapi juga dalam hubungannya dengan konteks budaya, sejarah, dan bahasa di mana teks tersebut muncul. Ini memungkinkan pemahaman yang lebih dalam tentang makna yang dapat berubah seiring waktu dan transformasi dalam konteks budaya. Berbeda secara signifikan dengan ajaran Al-Qur’an. Beberapa siswa mungkin sulit memahami atau menerima konsep-konsep Al-Qur’an karena adanya persepsi atau stereotip tertentu tentang Islam. Ini bisa membuat penyampaian nilai-nilai Al-Qur’an lebih rumit karena memerlukan pendekatan yang menghormati dan memahami keberagaman pemahaman siswa.
Globalization is a phenomenon that has dominated world change in recent decades. Information and communication technology, especially the internet, has played a big role in accelerating globalization. It enables individuals and organizations to communicate, collaborate, and share information quickly around the world. This approach uses Maudhu'i interpretation to understand that the text of the Qur'an can not only be seen individually but also in relation to the cultural, historical and linguistic context in which the text appears. This allows a deeper understanding of meanings that can change over time and transformations in cultural contexts. It differs significantly from the teachings of the Koran. Some students may find it difficult to understand or accept the concepts of the Koran because of certain perceptions or stereotypes about Islam. This can make conveying the values ​​of the Qur'an more complicated because it requires an approach that respects and understands the diversity of students' understandings
The impact of special exercises using the (Wheatley's) strategy on learning to perform the underhand serve and reception skills in volleyball for students
Authors: Abbas Ithra , Shalash Maher 
Published: January 2025

Workers in the field of educational sciences seek to advance the level of their students, and one of the most important of these sciences is sports sciences, which have their own methods and techniques in line with the levels of each age stage, which requires the subject teacher to be well versed in all modern teaching methods and techniques. The research aimed to prepare special exercises in accordance with the strategy of Wheatley in learning the skills of transmission and receiving volleyball for students of Najaf High School for the distinguished, as well as knowing the preference of using (Wheatley strategy or the approach followed) in the research variables as well as to choose the school team participating in the Najaf Education Championship, and the researchers used the experimental approach with two control and experimental groups with pre- and post-tests and conducted two tests (transmission from the bottom, receiving the transmitter) and the research sample was represented by the fifth preparatory grade school students for the academic year 2023-2024, which numbered 24 students from a community of origin numbering 72 students, as they were selected in a simple random way (lottery) and were divided into two control and experimental groups, and each group (12) students The statistical bag (SPSS) was used to extract the results, and after presenting and discussing the results, it was concluded that there is a positive impact of Wheatley's strategy in learning the skills of transmission and receiving volleyball between the pre-post-tests for both groups as well as between the control and experimental groups and for the benefit of the experimental group, and the researchers recommend the need to use the Wheatley strategy on other games, and pay attention to updating teaching methods and techniques in line with age groups.
El consentimiento informado en la práctica del aborto
Authors: Moia Angel Luis 
Published: January 2025

The admission of the so-called voluntary interruption of pregnancy (abortion) has raised several questions about its articulation with the rest of the regulations relating to medical treatments. In particular, the harmonization with the civil and commercial code, the law of patients' rights and the law of comprehensive health care during pregnancy and early childhood with those of conventional source. The confluence of these norms contributes to signifying the content and extent of informed consent. This must be specified in a clear, precise, adequate and complete manner. At the same time, it must be accompanied by the appropriate studies for the gestation stage, which can contribute to the decision to carry out the practice
Refugio en la edad
Authors: Gómez Ramos Grecia A. , Nausneris Zavala Salomé 
Published: January 2025

The protection of the elderly in situations of housing vulnerability requires a comprehensive and adaptive perspective. Judicial mechanisms must consider advanced age and its implications to ensure that the right to decent and secure housing remains intact. The lifelong allocation of housing use can be an appropriate solution in cases of extreme vulnerability, reflecting a genuine commitment to the principles of justice, equality, and dignity for all citizens.
Deconstructing the Properties of Solar Super Active Region 13664 in the Context of the Historic Geomagnetic Storm of 2024 May 10–11
Authors: Jaswal Priyansh , Sinha Suvadip , Nandy Dibyendu 
Published: January 2025

Abstract
Active regions (ARs) are sites of strong magnetic fields on the solar surface whose size can be several times that of Earth. They spawn dynamic activity, sometimes resulting in severe space weather. Some ARs characterized by extraordinary magnetic properties and exhibiting extreme activity are termed as super active regions (SARs). Recently, solar AR 13664 produced 23 X-class flares and unleashed multiple coronal mass ejections, which triggered a severe geomagnetic storm during 2024 May 10–11—the strongest storm on record since 2003. Here, we put AR 13664 in historical context over the cumulative period of 1874 May–2024 June. We find that AR 13664 stands at the 99.95th percentile in the distribution of area over 1874 May–2024 June and at the 99.10th percentile in terms of flux content among all ARs over the period 1996 April–2024 June. Our analysis indicates that five of its magnetic properties rank at the 100.00th percentile among all ARs observed during 2010 May–2024 June by the Solar Dynamic Observatory. A total of 16 magnetic properties of AR 13664 are ranked higher than the 99.00th percentile when compared to other ARs recorded in Space-weather Helioseismic Magnetic Imager Active Region Patch data series, which includes all well-established flare relevant parameters. Furthermore, we demonstrate that AR 13664 reached its most dynamic flare productive state following a rapid rate of rise of its flare-relevant parameters and that the X-class flares were more frequent near their peak values. Our analyses establish AR 13644 to be an SAR and provide a paradigm for investigating their flare-relevant physical characteristics.