bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luminescence characteristics and X‐ray‐induced defects in BaFBr:Eu2+ storage phosphor
Authors: Sangeetha Lakshmi Narasimhan , Lakshmanan Arunachalam , Sivakumar Vairan 
Published: July 2023

AbstractThree different approaches used to synthesize a sensitive BaFBr:Eu2+ X‐ray storage photostimulated luminescence (PSL) phosphor at 850°C for 1 h in a reducing atmosphere are reported. The effects of F/Br and Eu concentration on photoluminescence (PL) and PSL sensitivities synthesized by the three approaches were compared. In the first recipe, BaFBr:Eu2+ prepared using a BaF2, BaBr2 and EuF3 mixture using solid‐state diffusion (Recipe I), even in a reducing atmosphere, yielded a low PL and PSL intensity due to oxygen contamination that acted as competing hole traps. When BaFBr:Eu2+ was prepared using ammonium bromide and ammonium fluoride by two different recipes (Recipes II and III), oxygen contamination was eliminated, resulting in enhanced PSL efficiency. The proposed PSL process in BaFBr:Eu2+ was consistent with the experimental results. Increased F/Br molar ratios would incorporate fluorine ion interstitials that act as hole traps accompanied by bromine ion vacancies that act as electron traps. Although two types of F centres, F(Br−) and F(F−) are possible, F(Br−) centres formed during X‐irradiation are only vital for the PSL process. Structural, morphology, and thermoluminescence (TL) properties of the samples were also examined using XRD, field emission scanning electron microscope (FESEM), energy‐dispersive X‐ray spectroscopy (EDAX), and TL studies.
Substance P‐Derived Extracellular‐Matrix‐Mimicking Peptide Hydrogel as a Cytocompatible Biomaterial Platform
Authors: Mukherjee Nabanita , Ghosh Surajit 
Published: July 2023

AbstractSelf‐assembled short peptide‐based hydrogel platforms have become widely applicable biomedical therapeutic maneuvers for their soft, tunable architecture, which can influence cellular behavior and morphology to an inordinate extent. In this work, a short supramolecular hydrogelator peptide, substance P, has been designed and synthesized from the C terminus conserved “FFGLM” section of a biologically abundant neuropeptide by using a fusion approach. In addition, to incorporate a good hydrophobic–hydrophilic balance, the truncated pentapeptide segment was further C‐terminally modified by the incorporation of an integrin‐binding “RGD” motif. Thanks to its N‐terminal Fmoc group, this octapeptide ensemble “FFGLMRGD” undergoes rapid self‐assembly to give rise to an injectable, pH‐responsive, hydrogel‐based self‐supporting platform that exhibited good cytocompatibility with the cultured mammalian cells under both 2D and 3D culture conditions without exerting any potent cytotoxic effect in a Live/Dead experiment. A rheological experiment demonstrated its hydrogel‐like mechanical properties, including thixotropicity. The atomic force microscopy and field emission scanning electron microscopy images of the fabricated hydrogel show a tangled fibrous surface topography owing to the presence of the N‐terminal Fmoc−FF residue. Furthermore, an in‐vitro scratch assay performed on fibroblast cell lines confirmed the wound‐ameliorating potency of this designed hydrogel; this substantiates its future therapeutic prospects.
Quantitative fluid overload in severe aortic stenosis refines cardiac damage and associates with worse outcomes
Authors: Halavina Kseniya , Koschutnik Matthias , Donà Carolina , Autherith Maximilian , Petric Fabian , Röckel Anna , Mascherbauer Katharina , Heitzinger Gregor , Dannenberg Varius , Hofer Felix , Winter Max‐Paul , Andreas Martin , Treibel Thomas A. , Goliasch Georg , Mascherbauer Julia , Hengstenberg Christian , Kammerlander Andreas A. , Bartko Philipp E. , Nitsche Christian 
Published: July 2023

AimsCardiac decompensation in aortic stenosis (AS) involves extra‐valvular cardiac damage and progressive fluid overload (FO). FO can be objectively quantified using bioimpedance spectroscopy. We aimed to assess the prognostic value of FO beyond established damage markers to guide risk stratification.Methods and resultsConsecutive patients with severe AS scheduled for transcatheter aortic valve implantation (TAVI) underwent prospective risk assessment with bioimpedance spectroscopy (BIS) and echocardiography. FO by BIS was defined as ≥1.0 L (0.0 L = euvolaemia). The extent of cardiac damage was assessed by echocardiography according to an established staging classification. Right‐sided cardiac damage (rCD) was defined as pulmonary vasculature/tricuspid/right ventricular damage. Hospitalization for heart failure (HHF) and/or death served as primary endpoint. In total, 880 patients (81 ± 7 years, 47% female) undergoing TAVI were included and 360 (41%) had FO. Clinical examination in patients with FO was unremarkable for congestion signs in >50%. A quarter had FO but no rCD (FO+/rCD−). FO+/rCD+ had the highest damage markers, including N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) levels. After 2.4 ± 1.0 years of follow‐up, 236 patients (27%) had reached the primary endpoint (29 HHF, 194 deaths, 13 both). Quantitatively, every 1.0 L increase in bioimpedance was associated with a 13% increase in event hazard (adjusted hazard ratio 1.13, 95% confidence interval 1.06–1.22, p < 0.001). FO provided incremental prognostic value to traditional risk markers (NT‐proBNP, EuroSCORE II, damage on echocardiography). Stratification according to FO and rCD yielded worse outcomes for FO+/rCD+ and FO+/rCD−, but not FO−/rCD+, compared to FO−/rCD−.ConclusionQuantitative FO in patients with severe AS improves risk prediction of worse post‐interventional outcomes compared to traditional risk assessment.
Synthesis of 5‐glycosylated β‐anhydroicaritine
Authors: Lan Qing , Wang Xianheng , Zhao Zhao , Zhao Changkuo 
Published: July 2023

AbstractGlycosylation plays an important role in many biological processes, and its structural changes have a significant impact on biological activity. Unlike natural icariin, icariside I, and icariside II, a simulated unnatural 5‐glycosylation (4) was designed to expand substrate adaptability and the pharmacological properties of the parent compound. Therefore, starting from commercially available icaritin, 5‐glycosylated icaritin was successfully synthesized in moderate yield through cyclization, selective 3‐alkylation, 5‐glycosylation, and hydrogenation steps. The structure was identified by 1H nuclear magnetic resonance (NMR), 13C NMR, MS, and x‐ray spectroscopy.
Verifying AXL and putative proteins as SARS‐CoV‐2 receptors by DnaE intein‐based rapid cell–cell fusion assay
Authors: Fang Quan , He Xiaobai , Zheng Xiaoguang , Fu Yu , Fu Ting , Luo Jingyi , Du Yaoqiang , Lan Jiajing , Yang Jun , Luo Yongneng , Chen Xiaopan , Zhou Naiming , Wang Zhen , Lyu Jianxin , Chen Linjie 
Published: July 2023

AbstractAs the understanding of the mechanisms of SARS‐CoV‐2 infection continues to grow, researchers have come to realize that ACE2 and TMPRSS2 receptors are not the only way for the virus to invade the host, and that there are many molecules that may serve as potential receptors or cofactors. The functionality of these numerous receptors, proposed by different research groups, demands a fast, simple, and accurate validation method. To address this issue, we here established a DnaE intein‐based cell‐cell fusion system, a key result of our study, which enables rapid simulation of SARS‐CoV‐2 host cell infection. This system allowed us to validate that proteins such as AXL function as SARS‐CoV‐2 spike protein receptors and synergize with ACE2 for cell invasion, and that proteins like NRP1 act as cofactors, facilitating ACE2‐mediated syncytium formation. Our results also suggest that mutations in the NTD of the SARS‐CoV‐2 Delta variant spike protein show a preferential selection for Spike‐AXL interaction over Spike‐LDLRAD3. In summary, our system serves as a crucial tool for the rapid and comprehensive verification of potential receptors, screening of SARS‐CoV‐2–neutralizing antibodies, or targeted drugs, bearing substantial implications for translational clinical applications.
Early Improved Functional Outcomes in Head and Neck Cancer Patients with Primary Tumor Detection
Authors: Kalavacherla Sandhya , Bernard Benjamin , Kim Sangwoo S. , Dornisch Anna , Blumenfeld Liza , Linnemeyer‐Risser Kristen , Sanghvi Parag , Guo Theresa 
Published: July 2023

ObjectivesWe characterize functional outcomes in head and neck cancer of unknown primary (CUP) based on primary site identification.MethodsIn this retrospective study, CUP cases were categorized as known primaries (KP) if a tumor was localized after diagnostic workup or persisting unknown primaries (UP). Age, sex, HPV status, diagnostic methods, and treatments regimens were collected. Pretreatment and short‐term posttreatment (3–6 months after completion of treatment) weights, PHQ‐9, Eating Assessment Tool (EAT‐10), and Voice Handicap Index (VHI‐10) scores were compared between UP and KP.ResultsAmong 67 CUP patients, 35 (52.2%) had identified primaries (91.4% oropharyngeal and 8.6% nasopharyngeal). KP patients were younger (58 vs. 64, p = 0.04) and more likely to be HPV‐positive (88.6% vs. 50%, p = 0.002). Overall detection rates were 16.7% for PET/CT, 34.7% for direct laryngoscopy, and 46.6% for transoral robotic oropharyngectomy. Diagnostic workup was not significantly different between groups. Patients with KP received smaller intermediate radiation dose volumes (436.5 vs. 278.9 cc, p = 0.03) and lower doses to the cricopharyngeal muscle (41.6 vs. 24.6 Gy, p = 0.03).Pretreatment weights, PHQ‐9, EAT‐10, and VHI‐10 scores did not differ between groups. However, posttreatment, UP had greater relative weight loss (−14.1% vs. −7.6%, p = 0.032), higher EAT‐10 scores (12.5 vs. 3, p = 0.004), and higher PHQ‐9 scores (6 vs. 1.4, p = 0.017). Specifically, UP reported more stressful swallowing, difficulty swallowing solids and pills, and swallowing affecting public eating.ConclusionKP patients experienced less weight loss, depression, and reduced swallowing dysfunction, highlighting an early functional benefit of primary tumor identification likely driven by reduced radiation treatment volumes.Level of Evidence4 Laryngoscope, 134:701–707, 2024
Copper(II) Complexes Supported by Bis(imino)pyridine Ligands: Synthesis and Catalysis on Azide‐Alkyne Click Reactions
Authors: Sahil Deepika , Yadav Seema , Dash Chandrakanta 
Published: July 2023

AbstractThe synthesis, characterization and catalytic activity of copper(II)‐bis(imino)pyridine pincer complexes were described. The copper(II) complexes (2 a and 2 b) were synthesized by the reaction of 2,6‐bis(imino)pyridine ligands with CuCl2 ⋅ 2H2O in methanol as a solvent. The copper(II) complexes were fully characterized by IR, UV‐Visible, Mass spectroscopy and elemental analysis. The copper(II) complexes 2 a and 2 b showed excellent catalytic activity towards azide‐alkyne cycloaddition (Click reaction) in water and produced regioselective product of 1,4‐disubstituted‐1,2,3‐triazoles. The copper(II) complex (2 b) with electron withdrawing CF3 group exhibited comparatively higher catalytic activity in azide‐alkyne cycloaddition reactions and produced up to 93 % of yield with 0.05 mol % of the catalyst loading.
Electrochemical Cellobiose Valorization: Anodic Oxidation to Cellobionic Acid and Cathodic Reduction to Cellobitol
Authors: Chávez Morejón Micjel , Kurig Nils , Tschauder Yannick S. , Harnisch Falk , Palkovits Regina 
Published: July 2023

AbstractThis study elucidates key parameters allowing the electrochemical valorization of cellobiose, by creating value‐added products by both, anodic oxidation, and cathodic reduction. We demonstrate the first electrochemical reduction of cellobiose to cellobitol in a divided cell using Pb as cathode, leading up to 49 % conversion, though with long reaction times (over 26 h) and low coulombic efficiency (
) of 4 %. The successful synthesis of cellobionic acid was demonstrated by mediated oxidation in an undivided electrochemical cell, using a graphite anode and CaBr2 as electrocatalytic mediator. Cellobiose oxidation was highly selective, allowing for up to 92 % conversion to cellobionic acid at 48 %
when using a charge of 2 FE.
Determining Roles of Potassium‐Feldspar Surface Characters in Affecting Ice Nucleation
Authors: Liang Meichen , Cheng Yongxin , Zhou Xin , Liu Jie , Wang Jianjun 
Published: July 2023

AbstractThe roles of surface characteristics of the feldspar surface on ice nucleation have remained elusive. Here, simple strategies are reported to quantitatively analyze the effects of the surface morphology and molecular composition of the potassium‐feldspar surface on ice nucleation. The steps are found to be responsible to the high ice nucleation efficacy according to the fact that water drop freezing temperature increases by about 4.5 °C atop the freshly cleavage feldspar surface being rich of steps comparing to the flattened ones. After the molecular component and atomic structure are destroyed by the fluorination, a tremendous decrease of the ice nucleation temperatures by around 9.0 °C is observed on both cleavage and flattened surfaces, and the steps still improve the ice nucleation activity of the hydrophobic cleavage surfaces. The influence of the surface composition also implies the importance of the molecular component and structure specificity on K‐feldspar in facilitating ice nucleation.
Structure and establishment of the German Cochlear Implant Registry (DCIR)
Authors: Stöver T. , Plontke S. K. , Guntinas-Lichius O. , Welkoborsky H-J. , Zahnert T. , Delank K. W. , Deitmer T. , Esser D. , Dietz A. , Wienke A. , Loth A. , Dazert S. 
Published: July 2023

AbstractHearing rehabilitation of patients with severe hearing loss or deafness using cochlear implants (CI) is a very successful but also complex and lifelong process that requires high quality standards for structure, process, and results. Medical registries represent an ideal tool for conducting quality control relevant to care while at the same time collecting scientific data. Therefore, at the initiative of the Executive Committee of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), a Germany-wide CI registry (the German Cochlear Implant Register, DCIR) was to be established. The following goals were to be achieved: 1) legal and contractual basis for the register; 2) definition of the register contents; 3) development of evaluation standards (hospital-specific and national annual reports); 4) development of a logo; 5) practical operation of the registry. After defining a catalog of services that defines the content, structure, and operation of the DCIR, a registry operator with audiological expertise was sought. After considering various offers, the registry was technically implemented in cooperation with the provider INNOFORCE (Ruggell, Liechtenstein) as registry operator. This also included the realization of an interface for data transfer from previously existing databases and development of a data protection concept for productive operation of the DCIR under the scientific leadership of the DGHNO-KHC Executive Committee. Since January 2022, it has been possible for participating hospitals to enter pseudonymized data into the DCIR. To date, 75 hospitals in Germany have contractually agreed to participate in the registry. During the first 15 months, data from over 2500 implants in over 2000 patients were registered in the DCIR. The work presented here describes the structuring, development, and successful establishment of the DCIR. Introduction of the DCIR represents an important milestone of future scientifically based quality control in CI care. The registry presented here can therefore be considered as an example for other areas of medical care and thus also sets an international standard.
Early treatment response to piperacillin/tazobactam in patients with bloodstream infections caused by non-ESBL ampicillin/sulbactam-resistant Escherichia coli: a binational cohort study
Authors: Tobudic Selma , Bahrs Christina , Schneider Lisa , Paulussen Emilia , Bartonickova Lucie , Hagel Stefan , Starzengruber Peter , Burgmann Heinz , Pletz Mathias W. 
Published: July 2023

Abstract
Purpose
This study aimed to compare treatment outcomes for bloodstream infections (BSI) caused by a piperacillin/tazobactam (PIP/TAZ)-susceptible E. coli among three patient groups: BSI caused by ampicillin/sulbactam (AMP/SLB)-resistant isolates treated with PIP/TAZ, BSI caused by AMP/SLB-sensitive isolates treated with PIP/TAZ, and BSI caused by AMP/SLB-resistant isolates treated with another monotherapy.

Methods
This retrospective study was conducted in two academic centres in Europe. Adult patients with E. coli BSI were screened from 2014 to 2020. Inclusion criteria were non-ESBL BSI and initial monotherapy for ≥ 72 h. To reduce the expected bias between the patient groups, propensity score matching was performed. The primary outcome was early treatment response after 72 h and required absence of SOFA score increase in ICU/IMC patients, as well as resolution of fever, leukocytosis, and bacteraemia.

Results
Of the 1707 patients screened, 315 (18.5%) were included in the final analysis. Urinary tract infection was the most common source of BSI (54.9%). Monotherapies other than PIP/TAZ were cephalosporins (48.6%), carbapenems (34.3%), and quinolones (17.1%). Enhanced early treatment response rate was detected (p = 0.04) in patients with BSI caused by AMP/SLB-resistant isolates treated with another monotherapy (74.3%) compared to those treated with PIP/TAZ (57.1%), and was mainly driven by the use of cephalosporins and quinolones (p ≤ 0.03). Clinical success, 28-day mortality, and rate of relapsing BSI did not significantly differ between the groups.

Conclusions
Our study suggests that initial use of PIP/TAZ may be associated with reduced early treatment response in E. coli BSI caused by AMP/SLB-resistant isolates compared to alternative monotherapies.
Reducing Poverty and Building Capacity—Perceived Child and Family Impacts of the Child Tax Credit Expansion
Authors: Dugger R. , Weaver R. G. , Bean M. K. , Brickhouse T. H. , Brice P. , Siceloff E. R. , Armstrong B. , Beets M. , Adams E. L. 
Published: July 2023

AbstractThis study aims to evaluate the perceived impact of the Child Tax Credit expansion on families’ physical, mental, and financial well-being utilizing rigorous qualitative methodology. Parents (n = 40, ages: 20–49 years, median income: $36,000–48,000/year) in the southeastern USA completed interviews in October–November of 2020 after they received 3–4 monthly Child Tax Credit payments. Parents were classified into two groups (e.g., household income above [n = 21] vs. below [n = 19] 200% of the federal poverty line) for qualitative inductive analysis. Pre-ECTC themes were mapped onto the Hidden Dimensions of Poverty Framework. Across income groups, the expansion positively impacted family relationships, reduced stress, and facilitated meeting routine needs (e.g., food, housing costs). Parents with low-income were empowered to purchase greater volumes of food and invest in quality-of-life improvements (e.g., child extracurricular programming, family outings) for their children. Parents expressed disappointment around the expansion’s termination in December of 2021. The expanded Child Tax Credit empowered families to improve their well-being and reduced financial and emotional burdens. Personal anecdotes of public experiences with policy change can have a significant impact on federal policy decision-making. Parents perceived the ECTC improved their family well-being and desired its maintenance. This unconditional income assistance may be a viable strategy to significantly improve quality of life, if sustained long term. The health impacts and the cost benefit of this policy change should be evaluated.
Inferior and Medially Based Breast Parenchymal Rotation Flap: A New Mastopexy Technique for Replacing Breast Volume After Breast Implant Explantation
Authors: Sözer Sadri Ozan , Sibar Serhat 
Published: July 2023

Abstract

Background
Recently, a growing number of patients have been opting for the removal of breast implants. This often results in a degree of volume loss that can vary from mild to substantial, contingent on the size of the implant, with many patients requiring a mastopexy. Although autoaugmentation mastopexy serves as the primary surgical approach to restore shape and fill the void left by the implant, the fullness attained with the implant cannot be replicated through autoaugmentation.

Objectives
Our goal was to present the technical details and utilization of an inferomedial pedicle–based breast parenchymal flap, without rotational restriction from the parenchyma, for autoaugmentation after explantation.

Methods
A retrospective chart review was performed of 12 patients who underwent surgery with this technique between the years of 2019 to 2022, with emphasis on reasons for explantation, early and late complications, and satisfaction scores on a Likert scale.

Results
Capsular contracture was the most common reason for explantation, and only 2 patients experienced minor wound dehiscence in the early postoperative period. With a mean follow-up of nearly 2 years, no bottoming out was encountered in any of the patients, and satisfactory breast shape was obtained. Further, postoperative satisfaction was significantly higher than preoperative satisfaction.

Conclusions
The inferomedial-based parenchymal rotation flap is a new procedure that can be applied in this patient group because of its wide rotation arc and reliable vascularity. It is also an effective option for creating the desired conical breast shape in patients who do not want breast implants over the long term.

Level of Evidence: 4
Signatures of kin selection in a natural population of the bacteria Bacillus subtilis
Authors: Belcher Laurence J , Dewar Anna E , Hao Chunhui , Ghoul Melanie , West Stuart A 
Published: July 2023

Abstract
Laboratory experiments have suggested that bacteria perform a range of cooperative behaviors, which are favored because they are directed toward relatives (kin selection). However, there is a lack of evidence for cooperation and kin selection in natural bacterial populations. Molecular population genetics offers a promising method to study natural populations because the theory predicts that kin selection will lead to relaxed selection, which will result in increased polymorphism and divergence at cooperative genes. Examining a natural population of Bacillus subtilis, we found consistent evidence that putatively cooperative traits have higher polymorphism and greater divergence than putatively private traits expressed at the same rate. In addition, we were able to eliminate alternative explanations for these patterns and found more deleterious mutations in genes controlling putatively cooperative traits. Overall, our results suggest that cooperation is favored by kin selection, with an average relatedness of r = .79 between interacting individuals.