bluuebunny/crossref_metadata_2025_split huggingface dataset:
La narración de los motivos del conflicto armado de Tierra Caliente Michoacán, una breve interpretación
Authors: Vite Pérez Miguel Ángel 
Published: June 2023

El objetivo del artículo es la elaboración de una interpretación acerca de la desigualdad social y la violencia en la acción social armada mexicana a través del análisis de una narrativa formada mediante los motivos, vinculados con las creencias, expresados en la prensa escrita, considerada como un vehículo de una diversidad de opiniones de actores protagonistas de los eventos a estudiar. Por tanto, y de manera general, se examinó los motivos de los principales participantes en el conflicto armado regional en Michoacán.
El resultado fue que la desigualdad social y la violencia mexicana han configurado acciones sociales armadas punitivas, que comparten el punto de vista gubernamental, sobre la inseguridad pública, provocada principalmente por las organizaciones criminales, que el mismo gobierno, considera ajenas al ejercicio de su poder.
Metastases of melanoma in lymph nodes with unknown primary site
Authors: Krylovetskaya M. A. , Komarov I. G. , Komarov M. I. , Gusarova O. A. , Malikhova O. A. 
Published: June 2023

Introduction. Melanoma is a malignant tumor that develops from melanocytes, has a high malignant potential and is characterized by early and aggressive metastasis. Just like with many other malignant neoplasms, melanoma can be clinically manifested by metastases in the absence of a primary focus. In the world and in Russia, there has been a steady increase in the incidence of melanoma over the past thirty years. Identifiation of the primary focus with an established diagnosis of metastases of a malignant tumor during life occurs no more than 25 % of cases. Even at autopsy, the primary focus is found on average in 15–20 % of patients, subject to a complete examination of the patient during his lifetime. The prognostic value of identifying the primary focus in melanoma remains unclear.Objective. To improve the diagnosis and treatment of patients with melanoma metastases without an identifid primary focus by assessing the signifiance of various factors, including the fact that the primary tumor was detected.Materials and methods. Since 2005 to 2019 at the National Medical Research Centre of Oncology n. a. N. N. Blokhin (Moscow, Russia) 196 patients with metastases of melanoma in the lymph nodes were observed and treated. Patient medical history were analyzed retrospectively and prospectively. All patients were followed up on an ambulatory after treatment. The inflence of the main clinical and morphological characteristics on the survival rates of patients was assessed. Patients with a morphologically confimed diagnosis of melanoma metastases in
Real-time simulation of the transplanted tooth using model order reduction
Authors: Lahoud Pierre , Badrou Arif , Ducret Maxime , Farges Jean-Christophe , Jacobs Reinhilde , Bel-Brunon Aline , EzEldeen Mostafa , Blal Nawfal , Richert Raphaël 
Published: June 2023

The biomechanics of transplanted teeth remain poorly understood due to a lack of models. In this context, finite element (FE) analysis has been used to evaluate the influence of occlusal morphology and root form on the biomechanical behavior of the transplanted tooth, but the construction of a FE model is extremely time-consuming. Model order reduction (MOR) techniques have been used in the medical field to reduce computing time, and the present study aimed to develop a reduced model of a transplanted tooth using the higher-order proper generalized decomposition method. The FE model of a previous study was used to learn von Mises root stress, and axial and lateral forces were used to simulate different occlusions between 75 and 175N. The error of the reduced model varied between 0.1% and 5.9% according to the subdomain, and was the highest for the highest lateral forces. The time for the FE simulation varied between 2.3 and 7.2 h. In comparison, the reduced model was built in 17s and interpolation of new results took approximately 2.10−2s. The use of MOR reduced the time for delivering the root stresses by a mean 5.9 h. The biomechanical behavior of a transplanted tooth simulated by FE models was accurately captured with a significant decrease of computing time. Future studies could include using jaw tracking devices for clinical use and the development of more realistic real-time simulations of tooth autotransplantation surgery.
Green hydrogen production ensemble forecasting based on hybrid dynamic optimization algorithm
Authors: Alhussan Amel Ali , El-Kenawy El-Sayed M. , Saeed Mohammed A. , Ibrahim Abdelhameed , Abdelhamid Abdelaziz A. , Eid Marwa M. , El-Said M. , Khafaga Doaa Sami , Abualigah Laith , Elbaksawi Osama 
Published: June 2023

Solar-powered water electrolysis can produce clean hydrogen for sustainable energy systems. Accurate solar energy generation forecasts are necessary for system operation and planning. Al-Biruni Earth Radius (BER) and Particle Swarm Optimization (PSO) are used in this paper to ensemble forecast solar hydrogen generation. The suggested method optimizes the dynamic hyperparameters of the deep learning model of recurrent neural network (RNN) using the BER metaheuristic search optimization algorithm and PSO algorithm. We used data from the HI-SEAS weather station in Hawaii for 4 months (September through December 2016). We will forecast the level of solar energy production next season in our simulations and compare our results to those of other forecasting approaches. Regarding accuracy, resilience, and computational economy, the results show that the BER-PSO-RNN algorithm has great potential as a useful tool for ensemble forecasting of solar hydrogen generation, which has important ramifications for the planning and execution of such systems. The accuracy of the proposed algorithm is confirmed by two statistical analysis tests, such as Wilcoxon’s rank-sum and one-way analysis of variance (ANOVA). With the use of the proposed BER-PSO-RNN algorithm that excels in processing and forecasting time-series data, we discovered that with the proposed algorithm, the Solar System could produce, on average, 0.622 kg/day of hydrogen during the season in comparison with other algorithms.
The DNA damage repair-related lncRNAs signature predicts the prognosis and immunotherapy response in gastric cancer
Authors: Zhao Zidan , Mak Tsz Kin , Shi Yuntao , Huang Huaping , Huo Mingyu , Zhang Changhua 
Published: June 2023

BackgroundGastric cancer (GC) is one of the most prevalent cancers, and it has unsatisfactory overall treatment outcomes. DNA damage repair (DDR) is a complicated process for signal transduction that causes cancer. lncRNAs can influence the formation and incidence of cancers by influencing DDR-related mRNAs/miRNAs. A DDR-related lncRNA prognostic model is urgently needed to improve treatment strategies.MethodsThe data of GC samples were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. A total of 588 mRNAs involved in DDR were selected from MSigDB, 62 differentially expressed mRNAs from TCGA-STAD were obtained, and 137 lncRNAs were correlated with these mRNAs. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses were used to develop a DDR-related lncRNA prognostic model. Based on the risk model, the differentially expressed gene signature A/B in the low-risk and high-risk groups of TCGA-STAD was identified for further validation.ResultsThe prognosis model of 5 genes (AC145285.6, MAGI2-AS3, AL590705.3, AC007405.3, and LINC00106) was constructed and classified into two risk groups. We found that GC patients with a low-risk score had a better OS than those with a high-risk score. We found that the high-risk group tended to have higher TME scores. We also found that patients in the high-risk group had a higher proportion of resting CD4 T cells, monocytes, M2 macrophages, resting dendritic cells, and resting mast cells, whereas the low-risk subgroup had a greater abundance of activated CD4 T cells, follicular helper T cells, M0 macrophages, and M1 macrophages. We observed significant differences in the T-cell exclusion score, T-cell dysfunction, MSI, and TMB between the two risk groups. In addition, we found that patients treated with immunotherapy in the low-RS score group had a longer survival and a better prognosis than those in the high-RS score group.ConclusionThe prognostic model has a significant role in the TME, clinicopathological characteristics, prognosis, MSI, and drug sensitivity. We also discovered that patients treated with immunotherapy in the low-RS score group had a better prognosis. This work provides a foundation for improving the prognosis and response to immunotherapy among patients with GC.
mRNA-based SARS-CoV-2 Comirnaty vaccine elicits weak and short specific memory B cell response in individuals with no previous infection
Authors: Casado José L. , Vizcarra Pilar , Martín-Hondarza Adrián , Gómez-Maldonado Sandra , Muedra-Sánchez Magdalena , del Pino Judith , Mirabella Itria G. , Martín-Colmenarejo Sara , Haemmerle Johannes , Fernández-Escribano Marina , Vallejo Alejandro 
Published: June 2023

ObjectivesThe dynamics of the memory B cell (MBC) repertoire after SARS-CoV-2 vaccination is crucial for assessing long-term immunity. We compare spike-specific MBC responses between SARS-CoV-2 unexposed and recovered individuals, and their impact on breakthrough infections during follow-up.MethodsSpike-specific MBC and T cells were quantified at inclusion and after two doses of mRNA vaccine in a longitudinal cohort of 85 naïve and 64 recovered participants (47 with positive serology and 17 with negative serology after infection).ResultsAt inclusion, there was minimal spike-specific MBC in naïve SARS-CoV-2 individuals. After the second vaccine dose, MBCs were significantly boosted in naïve individuals, but reached a significantly lower level than that observed even in unvaccinated SARS-CoV-2 convalescents (p&lt;0.001). Furthermore, while the secondary memory B cell (MBC) population consisted of 100%, 33%, and 76% IgG+, IgM+, and IgA+ expressing cells, respectively, in the unexposed group, the MBC response showed a significant decrease across all isotypes. Similarly, although secondary specific IgG+, IgM+, and IgA+-MBC isotypes were found in 100%, 39%, and 76% of the unexposed participants, respectively, the magnitude of the MBC levels was significantly lower for all the isotypes compared to convalescents. Interestingly, convalescents without an initial serological response had a lower MBC response, like what found in unexposed subjects. There was an inverse correlation between specific MBCs (r=-0.307; p=0.027), especially for isotype IgA+ (r=-0.279, p=0.045), and the time since the second vaccination dose. Furthermore, during a median follow-up of 434 days (IQR, 339-495), 49 out of 149 individuals (33%) became infected, 29 in naïve and 20 in convalescent individuals, showing a significant correlation between spike-specific MBC magnitude after vaccination and the time for SARS-CoV-2 infection, especially for IgA+/IgG+ MBC isotypes.ConclusionsMBCs were primed by mRNA-based vaccination in most cases, but SARS-CoV-2 naïve individuals had a blunted specific MBC response, and this was associated with a shorter time to breakthrough SARS-CoV-2 infection.
Shell accumulation on seabed due to suspended coastal oyster farming and effects on burrowing capacity of the polychaete Perinereis aibuhitensis
Authors: Cao Yujie , Shi Rongjun , Han Tingting , Liu Huaxue , Huang Honghui , Qi Zhanhui 
Published: June 2023

Mariculture of bivalves (e.g., mussels, scallops, and oysters) is developing rapidly in coastal waters. This process releases shell debris that can accumulate on the seabed under farms. The ecological consequences of shell accumulation on the bioturbation of benthic macrofauna, which play a key role in the biogeochemical processes of sediment, are not yet fully understood. Thus, it is necessary to quantify the shell debris that accumulated under bivalves farms and evaluate whether the shell debris hinders the burrowing capacity of macrofauna. Oysters are common bivalve species cultured worldwide. However, no data are available on shell accumulation due to oyster farming and its possible effects on the burrowing capacity of polychaetes. Thus, we conducted a preliminary study on shells debris accumulation under an oyster farm in Daya Bay, southern China, and assessed the effects of shell accumulation on the burrowing activity of the polychaete Perinereis aibuhitensis in a mesocosm experiment for 32 days. The results showed that oyster farming significantly (p &lt; 0.05) increased the accumulation of shell debris under the farm. The amount of shell debris under oyster farm (6.0 ± 1.3 kg (dry weight (DW)) m-2 or 130.0 ± 24.7 g (DW) kg-1 dry sediment) was approximately two times that in a non-culture area (3.5 ± 0.9 kg (DW) m-2 or 74.9 ± 10.5 g (DW) kg-1 dry sediment). The presence of shell debris did not affect the survival of P. aibuhitensis in experiment, but the animals in sediment with shell added exhibited greater losses of body weight compared with those without, indicating that the presence of shell causes animals to expend more energy in burrowing. The numbers of burrowing holes were lower in sediment with shell debris added compared with those in sediment without shell addition throughout the experiment. Whereas, this does not due to the P. aibuhitensis in +Shell treatment were less active in terms of their burrowing activities. The lower numbers of holes in +Shell treatment was mainly due to P. aibuhitensis were unable to use surface areas where shells were present, the amount of area occupied by shell material physically prevented P. aibuhitensis from forming burrows in these locations. The hindering effects of shells on the burrowing activity of P. aibuhitensis would decrease as the shells degraded into debris. Therefore, we recommend using small shells when conducting “shell addition” bioremediation strategies to avoid the possible negative effects of shells on burrowing by polychaetes.
IL-1R2-based biomarker models predict melioidosis mortality independent of clinical data
Authors: Kaewarpai Taniya , Wright Shelton W. , Yimthin Thatcha , Phunpang Rungnapa , Dulsuk Adul , Lovelace-Macon Lara , Rerolle Guilhem F. , Dow Denisse B. , Hantrakun Viriya , Day Nicholas P. J. , Lertmemongkolchai Ganjana , Limmathurotsakul Direk , West T. Eoin , Chantratita Narisara 
Published: June 2023

IntroductionMelioidosis is an often-fatal tropical infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, but few studies have identified promising biomarker candidates to predict outcome.MethodsIn 78 prospectively enrolled patients hospitalized with melioidosis, six candidate protein biomarkers, identified from the literature, were measured in plasma at enrollment. A multi-biomarker model was developed using least absolute shrinkage and selection operator (LASSO) regression, and mortality discrimination was compared to a clinical variable model by receiver operating characteristic curve analysis. Mortality prediction was confirmed in an external validation set of 191 prospectively enrolled patients hospitalized with melioidosis.ResultsLASSO regression selected IL-1R2 and soluble triggering receptor on myeloid cells 1 (sTREM-1) for inclusion in the candidate biomarker model. The areas under the receiver operating characteristic curve (AUC) for mortality discrimination for the IL-1R2 + sTREM-1 model (AUC 0.81, 95% CI 0.72–0.91) as well as for an IL-1R2-only model (AUC 0.78, 95% CI 0.68–0.88) were higher than for a model based on a modified Sequential Organ Failure Assessment (SOFA) score (AUC 0.69, 95% CI 0.56–0.81, p &lt; 0.01, p = 0.03, respectively). In the external validation set, the IL-1R2 + sTREM-1 model (AUC 0.86, 95% CI 0.81–0.92) had superior 28-day mortality discrimination compared to a modified SOFA model (AUC 0.80, 95% CI 0.74–0.86, p &lt; 0.01) and was similar to a model containing IL-1R2 alone (AUC 0.82, 95% CI 0.76–0.88, p = 0.33).ConclusionBiomarker models containing IL-1R2 had improved 28-day mortality prediction compared to clinical variable models in melioidosis and may be targets for future, rapid test development.
Mill dams impact microbiome structure and depth distribution in riparian sediments
Authors: Kan Jinjun , Peck Erin K. , Zgleszewski Laura , Peipoch Marc , Inamdar Shreeram 
Published: June 2023

IntroductionDamming has substantially fragmented and altered riverine ecosystems worldwide. Dams slow down streamflows, raise stream and groundwater levels, create anoxic or hypoxic hyporheic and riparian environments and result in deposition of fine sediments above dams. These sediments represent a good opportunity to study human legacies altering soil environments, for which we lack knowledge on microbial structure, depth distribution, and ecological function.MethodsHere, we compared high throughput sequencing of bacterial/ archaeal and fungal community structure (diversity and composition) and functional genes (i.e., nitrification and denitrification) at different depths (ranging from 0 to 4 m) in riparian sediments above breached and existing milldams in the Mid-Atlantic United States.ResultsWe found significant location- and depth-dependent changes in microbial community structure. Proteobacteria, Bacteroidetes, Firmicutes, Actinobacteria, Chloroflexi, Acidobacteria, Planctomycetes, Thaumarchaeota, and Verrucomicrobia were the major prokaryotic components while Ascomycota, Basidiomycota, Chytridiomycota, Mortierellomycota, Mucoromycota, and Rozellomycota dominated fungal sequences retrieved from sediment samples. Ammonia oxidizing genes (amoA for AOA) were higher at the sediment surface but decreased sharply with depth. Besides top layers, denitrifying genes (nosZ) were also present at depth, indicating a higher denitrification potential in the deeper layers. However, these results contrasted with in situ denitrification enzyme assay (DEA) measurements, suggesting the presence of dormant microbes and/or other nitrogen processes in deep sediments that compete with denitrification. In addition to enhanced depth stratification, our results also highlighted that dam removal increased species richness, microbial diversity, and nitrification.DiscussionLateral and vertical spatial distributions of soil microbiomes (both prokaryotes and fungi) suggest that not only sediment stratification but also concurrent watershed conditions are important in explaining the depth profiles of microbial communities and functional genes in dammed rivers. The results also provide valuable information and guidance to stakeholders and restoration projects.
Effects of Tai Chi on working memory in older adults: evidence from combined fNIRS and ERP
Authors: Wang Chen , Dai Yuanfu , Yang Yuan , Yuan Xiaoxia , Zhang Mengjie , Zeng Jia , Zhong Xiaoke , Meng Jiao , Jiang Changhao 
Published: June 2023

ObjectiveThe study aimed to investigate the effects of a 12-week Tai Chi exercise intervention on working memory in older adults using ERP-fNIRS.MethodFifty older adults were randomly assigned to either an experimental group receiving a 12-week Tai Chi exercise intervention or a control group receiving regular daily activities. Working memory was assessed using the n-back task before and after the intervention, and spatial and temporal components of neural function underlying the n-back task were measured using ERP-fNIRS.ResultsThe experimental group demonstrated significant improvements in reaction time and accuracy on the 2-back task and showed higher activation levels in the R-DLPFC. Additionally, the Tai Chi group displayed significant increases in P3 amplitude in the overall n-back task.ConclusionThese findings suggest that Tai Chi interventions can enhance working memory in older adults, as evidenced by increasing neural activity and improving HbO in the R-DLPFC during the 2-back task.
Long-term outcomes of coils embolization for superior hypophyseal artery aneurysms
Authors: Kang Yan-Po , Li Cheng-Yu , Chen Chun-Ting , Yeap Mun-Chun , Wong Ho-Fai , Wu Yi-Ming , Hsieh Po-Chuan , Liu Zhuo-Hao , Chuang Chi-Cheng , Chen Ching-Chang 
Published: June 2023

ObjectiveSuperior hypophyseal artery (SHA) aneurysms are intradural, and their rupture can result in subarachnoid hemorrhage. Considering the related surgical difficulty and anatomical restrictions, endovascular treatment (EVT) is considered the most favorable modality for SHA aneurysms; however, the long-term outcomes of EVT have rarely been reported. The study assessed the incidence of and risk factors for recurrence of SHA aneurysms after EVT as well as the correlation factors for SHA aneurysm rupture.MethodsWe included 112 patients with SHA aneurysms treated with EVT at our facility between 2009 and 2020. Here, EVT included non–stent-assisted (simple or balloon-assisted) or stent-assisted coiling. Flow diverter was not included because it was barely used due to its high cost under our national insurance’s limitation, and a high proportion of ruptured aneurysms in our series. Univariate and multivariate logistic regression was performed to evaluate the correlation factors for SHA aneurysm rupture, along with the incidence of and risk factors for post-EVT SHA aneurysm recurrence and re-treatment.ResultsIn our patients, the mean angiographic follow-up period was 3.12 years. The presence of type IA or IB cavernous internal carotid artery (cICA) was strongly correlated with SHA aneurysm rupture. Recurrence occurred in 17 (13.4%) patients, of which only 1 (1.4%) patient had received stent-assisted coiling. All cases of recurrence were observed within 2 years after EVT. The multivariate logistic regression results showed that ruptured aneurysm and non–stent-assisted coiling were independent risk factors for aneurysm recurrence. Of the 17 cases of aneurysm recurrence, 9 (52.9%) received re-treatment. Moreover, aneurysm rupture was the only factor significantly correlated with re-treatment in multivariate logistic regression. No re-recurrence was observed when a recurrent aneurysm was treated with stent-assisted coiling.ConclusionType I cICA was common factor for aneurysm rupture. Although flow-diverter treatment serves as another suitable technique that was not compared with, coils embolization was effective treatment modality for SHA aneurysms, leading to low recurrence and complication rates, especially with stent use. All cases of recurrence occurred within 2 years after EVT; they were strongly associated with prior aneurysm rupture. Further stent-assisted coiling was noticed to prevent re-recurrence.