bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins
Authors: Seo Tadahiko , Lowery Anthony M. , Xu Haifang , Giang William , Troyanovsky Sergey M. , Vincent Peter A. , Kowalczyk Andrew P. 
Published: August 2023

AbstractCadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part through endocytic membrane trafficking pathways that modulate cadherin cell surface levels. Here, we define the role for various MARCH family ubiquitin ligases in the regulation of cadherin degradation. We find that MARCH2 selectively downregulates VE-cadherin, resulting in loss of adherens junction proteins at cell borders and a loss of endothelial barrier function. Interestingly, N-cadherin is refractory to MARCH ligase expression, demonstrating that different classical cadherin family proteins are differentially regulated by MARCH family ligases. Using chimeric cadherins, we find that the specificity of different MARCH family ligases for different cadherins is conferred by the cadherin transmembrane domain. Further, juxta-membrane lysine residues are required for cadherin degradation by MARCH proteins. These findings expand our understanding of cadherin regulation and highlight a new role for mammalian MARCH family ubiquitin ligases in differentially regulating cadherin turnover.
Uranium-bearing dust induces differentiation and expansion of enteroendocrine cells in human colonoids
Authors: Atanga Roger , Appell Lidia L. , Lauer Fredine T. , Brearley Adrian , Campen Matthew J. , Castillo Eliseo F. , In Julie G. 
Published: August 2023

SUMMARYChronic exposure to environmental toxins and heavy metals has been associated with intestinal inflammation, increased susceptibility to pathogen-induced diseases, and higher incidences of colorectal cancer, all of which have been steadily increasing in prevalence for the past 40 years. The negative effects of heavy metals on barrier permeability and inhibition of intestinal epithelial healing have been described; however, transcriptomic changes within the intestinal epithelial cells and impacts on lineage differentiation are largely unknown. Uranium exposure remains an important environmental legacy and physiological health concern, with hundreds of abandoned uranium mines located in the Southwestern United States largely impacting underserved indigenous communities. Herein, using human colonoids, we defined the molecular and cellular changes that occur in response to uranium bearing dust (UBD) exposure. We used single cell RNA sequencing to define the molecular changes that occur to specific identities of colonic epithelial cells. We demonstrate that this environmental toxicant disrupts proliferation and induces hyperplastic differentiation of secretory lineage cells, particularly enteroendocrine cells (EEC). EECs respond to UBD exposure with increased differentiation intode novoEEC sub-types not found in control colonoids. This UBD-induced EEC differentiation does not occur via canonical transcription factorsNEUROG3orNEUROD1.These findings highlight the significance of crypts-based proliferative cells and secretory cell differentiation as major colonic responses to heavy metal-induced injury.
Re-examining the showrooming phenomenon: the moderating role of consumers' maximizing tendency
Authors: Hsieh Jung-Kuei , Kumar Sushant , Ko Ning-Yu 
Published: August 2023

PurposeShowrooming presents a complex and evolving challenge to retail managers, as it signifies the emergence of new forms of exchange rules. The purpose of this research is to investigate how factors responsible for information search and evaluation affect showrooming and also consider the consumer mindset as a moderator.Design/methodology/approachThis research undertakes three experimental designs to investigate how the push (i.e. assortment size), pull (i.e. price discount), and mooring (i.e. sunk cost) factors influence consumers' showrooming intention. Specifically, consumers' maximizing tendency plays the role of moderator.FindingsThe results reveal that push, pull, and mooring factors are significantly related to consumers' showrooming intention. Furthermore, the findings show that maximizers have higher showrooming intention than satisficers in the context of the push, pull, and mooring factors.Originality/valueBy integrating the push-pull-mooring framework and the maximizing mindset theory, this research proposes a novel research model and the empirical testing results support six hypotheses. The findings add to the body of knowledge in showrooming behavior by taking consumer mindset into account. The results also provide implications for practitioners to develop their retail strategies.
How and when is boundary-spanning behaviour related to innovative behaviour: role of intrinsic motivation and organisational support
Authors: Zhu Jinqiang , Xin Lu , Li Mengyi 
Published: August 2023

PurposeThis study aimed to investigate the underlying boundary conditions under which boundary-spanning behaviour has a positive or negative effect on innovative behaviour.Design/methodology/approachA multi-wave and multi-source research design was adopted to collect data. Data were analysed using the multilevel structural equation modelling and latent moderated structural equation approach.FindingsThe results showed that boundary-spanning behaviour was significantly and negatively associated with employees' innovative behaviour via ego depletion when employees' intrinsic motivation or organisational support was low. Additionally, boundary-spanning behaviour was significantly and positively associated with employees' innovative behaviour via ego depletion when employees' intrinsic motivation or organisational support was high.Originality/valueThis research suggests that the consequences of boundary-spanning behaviour are conditional, explaining the contrasting conclusions in this regard.
Observation of relationship between housing value and the number of building permits in the United States using time series method
Authors: Zhang Xingrui , Yang Eunhwa 
Published: August 2023

Purpose
Housing market is predominantly driven by supply and demand, and the measurement of housing supply plays a crucial role in understanding market dynamics. One such measure is the number of building permits (BPs) issued. Despite the importance of BPs as an economic indicator, direct links have yet to be drawn between BP and housing value index (HVI). The purpose of this paper is to establish links between HVI and BP.

Design/methodology/approach
Trials were conducted using data at the national, state and metropolitan statistical area (MSA) levels. For each trial, the Granger causality test was used first to identify causal relationships between HVI and BP. Subsequently, the vector autoregression model was implemented in an attempt to observe impulse–response relationships and to create a forecast for HVI.

Findings
Bidirectional causal relationships were observed between HVI and BP at the national, state and MSA levels. The number of issued BPs proves to be an indicator for HVI. Impulse response functions indicate that HVI responds negatively to an increase in BP in the short term of 4–7 months but positively to an increase in BP with a lag of 10–12 months.

Originality/value
To the best of the authors’ knowledge, this paper is the first in the body of knowledge that establishes the number of issued BPs as an indicator for housing value. The results drawn using impulse–response function are also novel and had not been observed in previous studies.
Interactive effects of armed conflict and climate change on gender vulnerability in Sub-Saharan Africa
Authors: Okoyeuzu Chinwe Regina , Ujunwa Angela Ifeanyi , Ujunwa Augustine , Nkwor Nelson N. , Kalu Ebere Ume , Al-Faryan Mamdouh Abdulaziz Saleh 
Published: August 2023

PurposeSub-Saharan Africa (SSA) is regarded as a region with one of the worst cases of armed conflict and climate risk. This paper examines the interactive effect of armed conflict and climate risk on gender vulnerability in SSA.Design/methodology/approachThe difference and system generalised method of movement (GMM) were used to examine the relationship between the variables using annualised data of 35 SSA countries from 1998 to 2019.FindingsThe paper found strong evidence that armed conflict and climate change are positive predictors of gender vulnerability. The impact of climate change on gender vulnerability is found to be more direct than indirect.Practical implicationsThe direct and indirect positive effect of armed conflict and climate change on gender vulnerability implies that climate change drives gender vulnerability through multiple channels. This underscores the need for a multi-disciplinary policy approach to addressing gender vulnerability problem in SSA.Originality/valueThe study contributes to the climate action debate by highlighting the need for climate action to incorporate gender inclusive policies such as massive investment in infrastructure and safety nets that offer protection to the most vulnerable girls and women affected by armed conflict and climate change. Societies should as a matter of urgency strive to structural barriers that predispose girls and women to biodiversity loss.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-09-2022-0595
Digital twin–based asset inspection and user–technology interactions
Authors: Voordijk Hans , Vahdatikhaki Faridaddin , Hesselink Lars 
Published: August 2023

Purpose
With the emergence of digital twins, the construction industry is looking toward improving the inspection and maintenance of all kinds of assets, such as bridges, roads and utilities. The purpose of this paper is to provide insights into how the development of an interactive digital twin creates a variety of interactions between users of this technology and assets to be monitored.

Design/methodology/approach
The development of a digital twin inspection model, focusing on the specific case of a sewage pumping station, is chosen as the subject of a case study. Through the development of this model, this study explores the various user–technology interactions that can be designed in a digital twin context.

Findings
Users interact with digital twins by following virtual instructions in a certain way, which creates a “quasi-other” relationship. A digital twin based on virtual reality (VR) also make users feel as if they are within the created VR of an inspection site, thereby immersing them in the VR environment. The design of a VR-based digital twin, which is determined by decisions made during the development process, shapes the context in which users interact with the technology and assets.

Originality/value
This study shows that a digital twin in construction practice may play different “actant” roles having different types of influences. Analyzing these actant roles and influences in terms of force and visibility adds a new perspective on the interaction between users and digital twins in construction and asset monitoring practice.
The implementation of IFRS9 in Gulf banks: using the GMM and the difference-in-differences with multiple time periods approaches
Authors: Abuaddous Murad 
Published: August 2023

Purpose
This paper aims to examine the impact of the mandatory adoption of (International Financial Reporting Standards [IFRS] 9) on loan provisions, nonperforming loans (NPL) and impairment loan loss in Gulf banks. This study also investigates potential variations in outcomes compared to prior models and explores the use of the Callaway and Sant’Anna (2021) estimator for difference-in-differences (DiD) with multiple time periods.

Design/methodology/approach
The research is based on a sample of 53 Gulf banks covering the period from 2012 to 2020. The study analyzes the changes in loan provisions, impairment loss and NPL following the implementation of IFRS 9. It uses statistical analysis and the DiD method to compare the outcomes between the experimental group (treated by IFRS 9) and the control group (not treated).

Findings
The findings reveal a statistically insignificant increase in loan provisions, impairment loss and NPL after the adoption of IFRS 9. These results align with previous studies and suggest that Gulf banks were proactive in anticipating and mitigating the impact of the new standard. The study also observes a synchronization of provisioning practices across Gulf countries and a certain level of consistency in recognizing loan losses.

Practical implications
The practical implications of this study suggest that Gulf banks have successfully absorbed the impact of IFRS 9 and have implemented collaborative approaches.

Originality/value
The study offers some new sight into IFRS9 outcomes in developing countries and opens the door for implementing a novel DiD estimation in future research studies.
A study of the underground banking system in Sri Lanka – a phenomenon of Boyle’s law
Authors: Sivaguru Dinesh , Tilakasiri Kamal 
Published: August 2023

Purpose
The purpose of the study is to examine the available literature to comprehend what the underground banking system is, for what purposes this method is used and how policymakers should proceed to address this issue.

Design/methodology/approach
The approach involved conducting this study and combining it with a critical analysis of the available literature as well as the available historical data. The sources the study has explored include government documents, public hearings, academic articles, case studies and articles available on the internet.

Findings
The study revealed prevention of illegal proceeds is critical, still regulating one entity, is a phenomenon of Boyle’s law, “squeezing the balloon”. If one end of the balloon is squeezed, making the volume smaller, the pressure inside increases, making the un-squeezed part of the balloon expand out. The real issue is not how criminals transfer their illegal earnings; it is the criminals themselves. Hence, the policy decision on this issue needs to be carefully considered.

Research limitations/implications
Due to the complexity of the operating system of Undiyal, this study had a number of limitations, as do many others. Firstly, there are no records of the Undiyal agents or the volumes of transactions publicly available. However, comprehending the scope of the underground operation that exists in the country is quite difficult.

Practical implications
The study contributes to the academic researchers grasping what type of future research should be focused on in this area according to the study.

Social implications
From the point of view of its practical application, the study seeks to resolve social issues that the middle-class population experiences on a daily basis and that have a huge and adverse impact on GDP.

Originality/value
To the best of the authors’ knowledge, this is an original contribution.
Knowledge production and commercialization from R&D: the pharmaceutical sector
Authors: García-Valderrama Teresa , Sanchez-Ortiz Jaime , Mulero-Mendigorri Eva 
Published: August 2023

PurposeThe objective of this work is to demonstrate the relationships between the two main processes of research and development (R&D) activities: the knowledge generation phase (KPP) and the knowledge commercialization, or transfer, phase (KCP), in a sector that is intensive in this type of activity, such as the pharmaceutical sector. In addition, within the framework of the general objective of this work, the authors propose two other objectives: (1) make advances in network efficiency measurement models, and (2) determine the factors associated with efficiency in the KPP and in the KCP in companies of the pharmaceutical sector in Spain.Design/methodology/approachA Network Data Envelopment Analysis (NDEA) model (Färe and Grosskopf, 2000) with categorical variables (Lee et al., 2020; Yeh and Chang, 2020) has been applied, and a sensitivity analysis of the obtained results has been performed through a DEA model of categorical variables, in accordance with the work of Banker and Morey (1986), to corroborate the results of the proposed model. The sample is made up of 77 companies in the pharmaceutical sector in Spain.FindingsThe results obtained point to a greater efficiency of pharmaceutical companies in the KPP, rather than in the KCP. Furthermore, the study finds that 1) alliances between companies have been the accelerating factors of efficiency in the KCP (but patents have slowed this down the most); 2) the quality of R&D and the number of R&D personnel are the factors that most affect efficiency in the KPP; and 3) the quality of R&D again, the benefits obtained and the position in the market are the factors that most affect efficiency in the KCP.Originality/valueThe authors have not found studies that show whether the efficiency obtained by R&D-intensive companies in the KPP phase is related to better results in terms of efficiency in the KCP phase. No papers have been found that analyse the role of alliances between R&D-intensive companies and patents, as agents that facilitate efficiency in the KCP phase, covering the gap in the research on both problems. Notwithstanding, this work opens up a research path which is related to the improvement of network efficiency models (since it includes categorical variables) and the assessment of the opinions of those who are responsible for R&D departments; it can be applied to decision-making on the aspects to improve efficiency in R&D-intensive companies.
Corporate social responsibility and employee outcomes: considering employee perspectives on the role of business
Authors: DeGhetto Kaitlyn , Russell Zachary A , McAllister Charn P 
Published: August 2023

Purpose
This study aims to investigate how employee perspectives on the role of business, specifically capitalist beliefs, affect the corporate social responsibility (CSR)–reputation–employee behavior relationship.

Design/methodology/approach
A conceptual model was developed, and to test the model empirically, survey data were collected over two phases from 192 working professionals. Data were analyzed in SAS using Hayes’s PROCESS approach.

Findings
Results of this study reveal that the positive employee outcomes (i.e. affective commitment and reduced turnover intentions), resulting from CSR, through perceived employer reputation (i.e. an employee’s perception of how others view their firm), are diminished when employees have strong capitalist beliefs.

Research limitations/implications
Building on the signaling and person–organization fit literatures, this study highlights the theoretical and managerial importance of recognizing employees’ ideological differences as well as the value of considering employee perceptions of reputation. Although many stakeholders value social responsibility, not all do, and a firm’s intended outcomes will vary depending on employees’ beliefs.

Originality/value
This study demonstrates that CSR not only affects institutional-level corporate reputation, as previously studied, but also affects employees’ behaviors through “perceived employer reputation”, or employee beliefs about how other stakeholders perceive the firm. Moreover, this study highlights the importance of understanding employee differences, including ideological differences, prior to engaging in certain types of CSR.
Deaths associated with electric shock injuries in children and adults: A 10‐year retrospective examination in Şanlıurfa, Southeast Turkey (2012–2022)
Authors: Dündar Ahmet Sedat , Altın İsmail , Aksöz Cihan , Sarın Abdullah Benna , Özdemir Bora 
Published: August 2023

AbstractElectric shock injuries (EIs) have high rates of morbidity and mortality in both children and adults. The aim of this study was to examine autopsy cases resulting from EIs and to compare pediatric and adult groups with respect to sociodemographic data, clinical characteristics, location of the incident, electricity entry–exit wound characteristics, current direction, pathological effects of the electric shocks on the body, and cause of death. A total of 8075 autopsies conducted between 2012 and 2022 were retrospectively examined. Şanliurfa is a city in the southeast of Turkey with the highest birth rate in the country. Of 123 cases of death resulting from EIs in Şanliurfa, 58 (47.2%) were children (age < 18 years). In the majority of children (81%), a low‐voltage injury resulted from a domestic appliance while the children were playing at home in a rural area. In the vast majority of adults, a high‐voltage injury (HVI) resulted from a workplace accident due to working with HVI materials in an area outside the home. The manner of death was accidental in all the electric shock injuries. The electricity entry and exit wounds formed as a result of EIs had similar characteristics in both children and adults, with no significant difference identified. In the province of Şanliurfa, Turkey, which borders Syria and where the main occupation is agricultural activities, there is a need to increase electrical safety precautions within the home, educate parents, and increase electrical safety conditions and worker education in the workplace.
Petrological and Geochemical Constraints on the Origin of Strongly Peraluminous Granitoids from the Triassic Guangtoushan Pluton in South Qinling
Authors: GUAN Qi , CAO Junlin , WANG Rixiang , XIE Peiling , XIA Wenyue , LI Xiaowei 
Published: August 2023

AbstractAs an important part of the early Mesozoic granites in the South Qinling tectonic belt (SQTB), the Guangtoushan pluton provides a material basis for research on the composition of magma sources and the effects of peritectic assemblage entrainment (PAE) on the changes in the granite composition. As shown by the results of LA‐ICP‐MS zircon U‐Pb dating, the Guangtoushan pluton was emplaced during the Late Triassic (214–212 Ma) and was formed in the post‐collision stage between the SQTB and the Yangtze plate. The collected samples had high SiO2 content and low Cr and Ni contents, indicating that the magmas did not undergo significant crust‐mantle mixing during their evolution. The Guangtoushan granitoids were distributed along the trend line of magmatic fractional crystallization in the F–An–Or diagram. This result, combined with the relatively homogeneous Sr‐Nd isotopic composition, implies that the Guangtoushan pluton underwent slight assimilation and contamination. As can be inferred from the comparison between the compositions of the Guangtoushan granitoids and various fluid‐absent experimental melts, the magma sources of the Guangtoushan granitoids contain a variety of materials, such as graywackes, pyroclastic graywackes, and pelites and are not derived from lower crustal mafic rocks. The correlation between the maficity and the major and trace elements further indicates that the strongly peraluminous granitoids from the Guangtoushan pluton was formed by the partial melting of biotite‐bearing crustal rocks and its magmatic evolution was accompanied by the entrainment of clinopyroxenes and accessory minerals.