bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disabled C3ar1/C5ar1 Signaling in Foxp3+ T Regulatory Cells Leads to TSDR Demethylation and Long-Term Stability
Authors: Medof M Edward , Rieder Sadiye A , Shevach Ethan M 
Published: September 2023

Abstract
Demethylation of the T regulatory cell (Treg)-specific demethylation region (TSDR) of the Foxp3 gene is the hallmark of Foxp3+ Treg stability, but the cellular signaling that programs this epigenetic state remains undefined. In this article, we show that suppressed C3a and C5a receptor (C3ar1/C5ar1) signaling in murine Tregs plays an obligate role. Murine C3ar1−/−C5ar1−/− Foxp3+ cells showed increased suppressor of cytokine signaling 1/2/3 expression, vitamin C stabilization, and ten-eleven translocation (TET) 1, TET2, and TET3 expression, all of which are linked to Treg stability. C3ar1−/−C5ar1−/− Foxp3+ cells additionally were devoid of BRD4 signaling that primes Th17 cell lineage commitment. Orally induced OVA-specific C3ar1−/−C5ar1−/− Foxp3+ OT-II Tregs transferred to OVA-immunized wild-type recipients remained &gt;90% Foxp3+ out to 4 mo, whereas identically generated CD55−/− (DAF−/−) Foxp3+ OT-II Tregs (in which C3ar1/C5ar1 signaling is potentiated) lost &gt;75% of Foxp3 expression by 14 d. After 4 mo in vivo, the C3ar1−/−C5ar1−/− Foxp3+ OT-II Tregs fully retained Foxp3 expression even with OVA challenge and produced copious TGF-β and IL-10. Their TSDR was demethylated comparably with that of thymic Tregs. They exhibited nuclear translocation of NFAT and NF-κB reported to stabilize thymic Tregs by inducing hairpin looping of the TSDR to the Foxp3 promoter. Thus, disabled CD4+ cell C3ar1/C5ar1 signaling triggers the sequential cellular events that lead to demethylation of the Foxp3 TSDR.
Metagenomics screening of viruses in Arusha, north Tanzania: a one health perspective across wild rodents, domestic dogs and humans
Authors: Issae Amina , Katakweba Abdul Ahmed , Kicheleri Rose , Chengula Augustino , Kasanga Christopher 
Published: September 2023

Background: One of the most significant and perilous challenges faced by African societies, including Tanzania, is the public health threat posed by zoonotic viruses. This study aimed to ascertain the presence of viruses in wild rodents, domestic dogs, and humans who shared the same environment.
Methods: A cross-sectional study was conducted in the Ngorongoro district from January to September 2022. Metagenomics next-generation sequencing technologies, including Illumina (MiSeq) and Oxford Nanopore (MinION), were employed to identify viruses in 530 blood samples collected from 200 humans, 230 wild rodents, and 100 domestic dogs. The captured wild rodents belonged to various species: Mastomys spp (n=87), Ratus spp (n=45), Avicanthis spp (n=40), Arcomys spp (n=28), Mus spp (n=16), and Field mice (n=14). The taxonomic classification of viruses was carried out using the Kraken2 program.
Results: A total of 20 RNA and 20 DNA viral families were detected. Zoonotic RNA families identified in rodents included Peribunyaviridae, Hantaviridae, Flaviviridae, Coronaviridae, Orthomyxoviridae, Paramyxoviridae, Retroviridae, Picornaviridae, Arenaviridae, Togaviridae, and Tobaniviridae. The zoonotic DNA families detected in rodents were Adenoviridae, Poxviridae, Herpesviridae, Anelloviridae, and Circoviridae. Peribunyaviridae and Hataviridae were identified in both humans and rodents. Unclassified +ssRNA viruses were found in dogs and humans. Herpesviridae was present in all three hosts. When compared to dogs and humans, rodents harbored zoonotic viruses that pose a significant public health safety concern.
Conclusion: The study unveiled a noteworthy pattern where the majority of RNA and DNA viruses with zoonotic potential were detected in wild rodents, as opposed to dogs and humans. These findings underscore the pivotal role played by wild rodent populations in the transmission and maintenance of such viruses.
Confiabilidad clínica de tres biosensores de glucosa evaluados contra método de referencia, durante la hipo, normo e hiperglucemia
Authors: Commendatore Víctor , Zamboni M , Godoy Bolzán Pedro , Benmelej A , Tedesco F , González C , Frias P 
Published: September 2023

Introducción: durante la práctica diaria utilizamos diferentes sensores de glucosa que permiten tomar decisiones, evaluar los resultados del tratamiento, prevenir o tratar situaciones de riesgo y empoderar al paciente respecto de su tratamiento, por lo cual resulta fundamental establecer la confiabilidad de los resultados ofrecidos por estos aparatos.
Objetivos: establecer la seguridad durante el uso clínico de tres biosensores, evaluados contra un método de referencia (MR) durante la hipo, normo e hiperglucemia.
Descripción de una serie de casos de pacientes con diabetes secundaria a acromegalia e hipercortisolismo endógeno: características clínicas y de laboratorio
Authors: Negri María Gabriela , Altamira María , Segura Gimena , Echegoyen Marisabel , Ferrada Pablo , Savina Mariela , Álvarez Analía , Lemos Patricia , Herrera Javier , Bringa Javier 
Published: September 2023

Introducción: la regulación de la glucemia requiere el accionar de distintas hormonas además de insulina. A través de mecanismos de insulinopenia o insulinorresistencia (IR), como en la acromegalia (Acro) o el síndrome de Cushing, las endocrinopatías pueden precipitar estados de hiperglucemia. La presencia de diabetes mellitus (DM) aumenta la morbimortalidad de estos pacientes, por lo cual es fundamental tanto el tratamiento como seguimiento de la enfermedad subyacente.
Objetivos: describir las características clínicas y bioquímicas de pacientes con Acro e hipercortisolismo (HiperC), comparando aquellos que presenten o no DM.
¿Es exitoso y seguro el manejo en clínica médica de la Cetoacidosis diabética? Evaluación de 90 episodios manejados protocolizadamente
Authors: Reynoso Carolina , Marcucci Guillermo , Dromi Luz Carolina , Lavandaio Hugo , Carena José Alberto 
Published: September 2023

Introducción: la cetoacidosis diabética (CAD) es una complicación aguda y grave que compromete la vida del paciente con diabetes mellitus (DM). Su mortalidad ha descendido gracias al empleo de protocolos de manejo y la educación de los pacientes. El éxito del manejo depende más del uso de protocolos estandarizados que del ámbito en donde se los emplee.
Objetivos: evaluar nuestros resultados en el manejo de 90 episodios de CAD que fueron manejados protocolizadamente en nuestro servicio en los últimos dos años.
Etiología y perfil de resistencia antimicrobiana en infecciones del pie diabético
Authors: Manzur Adriana , Marín Manuel , Sassul Martín , López Marisa , Ferrari Sandra , Salanitro Beatriz 
Published: September 2023

Introducción: el pie diabético infectado (PDI) es aquel que presenta infección de piel y partes blandas u óseas por debajo del maléolo; constituye la complicación más frecuente de diabetes que causa hospitalización y amputación. En nuestro hospital los pacientes con pie diabético son asistidos en un consultorio multidisciplinario; el 40% presenta infección leve moderada o grave.
Objetivos: describir los microorganismos (MO) etiológicos del PDI y su perfil de resistencia antimicrobiana.
A Rare Otological Presentation of Squamous Papilloma
Authors: Madan Tanuj , Goyal Sunil , Thongam Sachin 
Published: September 2023

Introduction:
Squamous papillomas (SPs) are benign epithelial neoplastic lesions commonly found in skin, oral mucosa, upper aerodigestive tract and genitals. Involvement of external auditory canal (EAC) by SP is extremely rare and whatever scarce literature is available is in the form of case reports. The exact incidence of this entity is still unknown. Consequently, its etiology, histopathological features, differential diagnoses and optimal management merit a better understanding by the Otolaryngologists.
Case report: We present a case of EAC SP in a 15 year old girl hailing from north-eastern India who presented to us with a mass in the EAC which was acutely painful. Contrast Enhanced Computed Tomography remained the gold standard and imaging study of choice for evaluation. However, the diagnosis was clinched only by histopathology. We also discuss our strategy of management along with a brief review of literature.
Conclusion:
Squamous papilloma has rarely been reported to affect the EAC. Human papilloma virus remains the most consistent etiological agent. Advanced imaging like contrast enhanced high resolution computed tomogram remains gold standard to evaluate any mass seen in EAC. Complete excision with cold steel technique or coblation with good post-operative care and follow up is the standard of care.
Investigating the Influence of Brand Communication and Brand Trust on Customer Commitment: An Examination from the Perspective of Customer Perception
Authors: Chen Xiuqun , Yu Shun-Chi , Sun Xuemei , Wang Dan 
Published: September 2023

Purpose: The study aims to investigate the role of different brand communication types on customer commitment and the impact of perceived fit on the bond between brand communication and brand trust in the context of China's international schools. This work offers profound insights into brand trust and communication strategies for brand decision-makers which directly shape customer commitment, a key aspect of the decision-making process.
Design/methodology/approach: Employing quantitative analysis, this study surveyed 318 parents of students from 6 international schools in China, constructing an SEM-PLS model to validate the influences of brand communication, perception of fit, and brand trust on customer commitment.
Findings: The research uncovered that controllable brand communication positively affects customer commitment via the mechanism of brand trust, while uncontrollable brand communication does not directly influence affective commitment. The mediation role of brand trust and affective commitment between brand communication and sustained commitment is observed. Perceived fit serves as a moderator in the relationship between brand communication and brand trust.
Practical Implications: Our findings empirically unravel the core determinants for the future development of international schools in China.
Originality/value: What sets this study apart is its empirical focus on China's international schools sector, an area not thoroughly explored in the existing literature. It bolsters the extant knowledge of brand relationship marketing, providing comprehensive insights into the interplay of brand communication, brand trust, and customer commitment. This paper emphasizes the vitality of effective brand management for gaining a competitive edge and achieving customer fit in the modern market, thereby offering invaluable implications for decision-makers in making scientifically informed brand management decisions.
A Comparative Review of Legislative Drafting Models in Common Law and Civil Law Systems
Authors: Ogunlade Femi Z. , Ologe Olumide A. 
Published: September 2023

Purpose: The common law legislative drafting model is aimed at achieving precision and accuracy in a legislative text which is meant to encompass every detail on a subject matter.
Methodology: Contrarily, the civil law drafting system seeks to introduce the main legal concept addressing a social phenomenon, while issues of detail will be regulated by secondary forms of law. In spite of these differences, some scholars of legislative drafting have in recent years been of the view that there is a meeting point between the two drafting models. Until recently, the comparative analysis of legislative drafting models was not given serious attention by legal scholars in comparative analysis. In this connection, while doctrinal legal approach will be employed as a descriptive and analytical review of the topic, comparative approach will be used to examine the various legislative drafting models. The objective of this paper is therefore to compare the common law and civil law legislative drafting models.
Findings: The findings show that while there are clear cut differences between the common law and civil law legislative drafting models. There has also been cross-fertilisation of styles particularly in drafting of international instruments involving drafters from common law and civil law jurisdictions.
Recommendations: This paper therefore recommends the need for legislative drafters in Nigeria to be properly trained with a view to learning the similarities and differences between common law and civil law legislative drafting models.
Translation and Psychometric Analysis of Urdu Version of Katz Index of Independence in Activities of Daily Living in Older Adults
Authors: Iftikhar Maham , Asghar Faiza , Asad Hafiz Usman , Kashif Faryal , Hanan Abdul 
Published: September 2023

Purpose: To translate the Katz index from English to Urdu and to establish its validity and reliability in older individuals.
Methodology: A cross sectional study was done in which the Katz index was adapted cross culturally after translated in Urdu. The elder adults of Wazirabad were the source of the data. The technique utilized was non-probability convenience sampling. Participants 60 years of age and older were included. For the translation Beaton guidelines were followed. The whole procedure of translation was done under the guidance of expert panel. Data were collected from the 102 older adults through the Urdu version of Katz index and Urdu version of Barthel index for association. Consent was taken from each participant. Data analysis was carried out using IBM SPSS 20 and was presented through tables and graphs.
Findings: Among 102 participants, 67 females (65.7%) and 35 males (34.3%) were included. There mean age was 68 with the standard deviation of 7.02. Cronbach's alpha value was 0.754 which indicates the good internal consistency of Urdu version of Katz index. The intra class correlation coefficient for the translated version was ICC 0.994(95%CI: 0.994-0.997). The correlation value r=0.953, p<0.01 shows its strong association with Urdu version of Barthel index indicating that the Urdu Katz index has good convergent validity.
Recommendations: The Katz index scale's Urdu version was found to be valid, accurate, reliable, and trustworthy. It can be extensively used by practitioners.
Early Pregnancy Fetal Cardiac Activity Detection by Superb Micro-Vascular Imaging (cSMI) Comparing with Color Doppler Ultrasound
Authors: Masud Riffat , Khurshid Faisal , Jameel Ghazal , Ashraf Mussarat 
Published: September 2023

Objective: To observe the sonographic advancement of the Doppler technique Superb Microvascular imaging (cSMI) for detecting fetal cardiac activity (FCA) in early pregnancy when not detected on grey scale ultrasound and conventional Doppler.
Study Design: Cross-sectional study.
Place and Duration of Study: Radiology Department and Gynaecological Department, Pakistan Atomic Energy Commission General Hospital in collaboration with Zahoor and Citilab Diagnostics Rawalpindi with a referral from Holy Family Hospital from Mar to Sep 2022.
Methodology: All cases were examined with Toshiba Aplio 300 and 500 ultrasound machines having software of Color Doppler Imaging (CDI), Advance Doppler Flow (ADF) and cSMI were used. Findings of grayscale Doppler including Color Power Doppler (CPD), Advance Doppler Flow (ADF) and cSMI patients with viable fetuses were followed at 2, 4 and 16 weeks and finally after 30 weeks of pregnancy.
Results: A total of 60 cases, 35 cases regarded viable pregnancy by detecting fetal cardiac activity (FCA) by greyscale, colour Doppler, and on cSMI. Five cases of nonviable pregnancies with no FCA on the Doppler cSMI greyscale and 5 cases of the embryonic sac (blighted ovum). Fifteen cases were reported nonviable with no cardiac flicker on the greyscale and no fetal cardiac activity on colour Doppler; however, fetal cardiac activity was detected on cSMI.
Conclusion: It is being concluded that cSMI (Superb Microvascular Imaging) is a new and highly sensitive method of detection of minimal vascular flow, disregarding any surrounding movement.
AN ASSESSMENT OF THE USAGE OF REFERENCE SERVICES BY USERS OF PROF. FESTUS AGHAGBO NWAKO LIBRARY, UNIZIK, AWKA - NIGERIA
Authors: Esemena JEROH  , Egwuonwu Ugochi IRUOMA  , Eberechi ADINDU  
Published: September 2023

This study examined the extent of use of reference services by users of the Prof.Festus Aghagbo Nwako Library, UNIZIK, Awka. The study adopted the descriptive survey design and questionnaire was distributed to 50 users of the library that were selected for the study. The responses to the items in the questionnaire were analysed by means of relevant descriptive statistical tools. The results were further presented by means of tables and discussed. Based on the analysis, the study found that apart from reprographic services, the Prof. Festus Aghagbo Nwako Library renders significant reference services to users of the library. Several problems associated with the delivery and patronage of the reference services were identified and solutions proffered. Given the research outcome, this study recommended that the library should educate students and other users about the reference and information services that are available at the library and efforts should be made by the Librarians to routinely update available reference sources in the Library.
Keywords: References Sources, Libraries, Library Services, Academic Libraries.
Spatio-Temporal Changes in Patterns of Land Use and Land Cover in Peri - Urban Areas of Faisalabad City
Authors: Afzal Iqra , Waseem Liaqate Ali , Khurshid Madiha , Maqbool Muhammad Shahid 
Published: September 2023

The changes in land use occurs with the passage of time in an area where the priorities of living standard changes. The increase in population and better socio-economic opportunities within urban localities influences the peripheral areas as well as the proximities. The aims of the study changes in land use patterns in peri urban areas. The current research evaluated the variation in land use preferences in Faisalabad city during the 2000, 2010 and 2017, covering 18 years. The change is detected through satellite images by applying the supervised classification in specified classes including vegetation, built up areas, barren land and water bodies. The analyses of the acquired images disclosed that the dominant land utilization in the peri-urban zone is the built-up or infrastructure development. This urban expansion and development mostly influenced the agricultural land or vegetation cover, as results vegetation cover reduced rapidly. Out of the total land area, the urban infrastructure area with 24% in 2000, increased to 46% in 2017. The results further indicated that the city is expanding rapidly towards the peri-urban areas. For the most part of the peri-urban, land is converted to urban land uses as for housing, infrastructure and commercial activities.
ҚЫЛМЫСТЫҚ БАНКРОТТЫҚ ЗАҢНАМАСЫ
Authors: РУСЯЕВ И. 
Published: September 2023

В статье показаны истоки правового регулирования банкротства вообще и криминального в частности. В этих целях автор обращается к двум редакциям Русской правды, судебникам и Собор-ному уложению, которые содержали нормы о банкротстве. Анализируются виды банкротства, при этом особое внимание обращается на правовые последствия, напрямую зависящие от них, раскры-ваются льготы, предусмотренные законодательством для иностранных инвесторов, показана динами-ка изменений норм о рассматриваемом феномене.
Мақалада банкроттықтың жалпы және қылмыстық-құқықтық реттеудің бастаулары көрсетілген. Осы мақсатта автор банкроттық туралы ережелерді қамтитын «Орыс ақиқаты» екі басылымына, Заңдар кодексіне және Кеңес кодексіне жүгінеді. Банкроттықтың түрлері талданады, оларға тікелей тәуелді құқықтық салдарларға ерекше назар аударылды, шетелдік инвесторлар үшін заңнамада көзделген жеңілдіктер ашылды, қарастырылып отырған құбылыс нормаларының өзгеру динамикасы көрсетіледі.
The article shows the origins of the legal regulation of bankruptcy in general and criminal in particular. For these purposes, the author turns to two editions of the Russian Truth, the Code of Laws and the Council Code, which contained the rules on bankruptcy. The types of bankruptcy are analyzed, with particular atten-tion paid to the legal consequences that directly depend on them, the benefits provided by the legislation for foreign investors are revealed, the dynamics of changes in the norms of the phenomenon under consideration is shown.
The Role of Deep Learning in Pharma: Revolutionizing Drug Discovery and Development.
Authors: Et al. Joti Devi 
Published: September 2023

- In recent years, the pharmaceutical industry has witnessed a transformative shift in the way drugs are discovered and developed, thanks to the advent of deep learning. This paper explores the profound impact of deep learning techniques on various stages of drug discovery and development, from target identification and lead optimization to clinical trials and personalized medicine. Deep learning, a subset of artificial intelligence, has demonstrated exceptional capabilities in handling complex biological data, including genomics, proteomics, and chemical informatics. It enables the integration of vast and diverse datasets, facilitating the identification of potential drug targets with unprecedented accuracy. Moreover, deep learning models can predict the binding affinity of drug candidates to specific target proteins, expediting the lead optimization process and reducing the need for costly experimental iterations. Deep learning algorithms enhance patient stratification and biomarker discovery, ultimately leading to more successful trials with higher patient response rates. Additionally, the ability to analyze real-world patient data aids in the identification of adverse events and the development of safer drugs.
Perrsonalized medicine is another area greatly influenced by deep learning, as it allows for tailoring treatments to individual patients based on their unique genetic and clinical profiles. This promises to revolutionize patient care, optimizing therapeutic outcomes while minimizing adverse effects. Despite the remarkable advancements facilitated by deep learning, there are challenges to address, such as data privacy, interpretability of models, and regulatory considerations. This paper discusses these challenges and potential solutions. Deep learning has emerged as a powerful tool in the pharmaceutical industry, driving innovation, efficiency, and precision in drug discovery and development. Its integration into the drug development pipeline holds the promise of accelerating the delivery of safer and more effective therapies to patients worldwide, marking a significant milestone in the evolution of pharmaceutical science.