bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatorenal dysfunction in patients with chronic thromboembolic pulmonary hypertension
Authors: Yogeswaran Athiththan , Zedler Daniel , Richter Manuel J. , Steinke Sonja , Rako Zvonimir A. , Kremer Nils C. , Grimminger Friedrich , Seeger Werner , Ghofrani Hossein Ardeschir , Gall Henning , Tello Khodr 
Published: July 2023

BackgroundCardiac interactions with organs such as the liver or kidneys have been described in different cardiovascular diseases. However, the clinical relevance of hepatorenal dysfunction in chronic thromboembolic pulmonary hypertension (CTEPH) remains unclear. We determined the association of hepatorenal dysfunction (measured using the Model for End-stage Liver Disease Sodium [MELDNa] score) with right heart function and survival in patients with CTEPH.MethodsWe analyzed all patients with CTEPH in the Giessen Pulmonary Hypertension Registry who had available MELDNa scores and were not taking vitamin K antagonists. The MELDNa score was calculated as MELD score − serum Na − (0.025 * MELD score * (140 − serum Na)) + 140; the MELD score was calculated as 10*(0.957*ln(creatinine)+0.378*ln(bilirubin)+1.12*ln(International Normalized Ratio))+6.43.ResultsSeventy-two patients were included (74% female; median [Q1, Q3] MELDNa: 9 [6, 11]). MELDNa correlated well with right atrial and ventricular function and pulmonary hemodynamics. Forward regression analysis revealed that hepatorenal dysfunction mainly depends on right atrial strain and tricuspid regurgitation, but not right ventricular systolic dysfunction. Hepatorenal dysfunction predicted mortality at baseline and follow-up (adjusted hazard ratios [95% confidence intervals] per unit increase of MELDNa: 1.6 [1.1, 2.4] and 1.8 [1.1, 2.9], respectively). Changes in hepatorenal function also predicted mortality.ConclusionHepatorenal dysfunction in CTEPH is primarily associated with venous congestion rather than cardiac forward failure. As a surrogate parameter for hepatorenal dysfunction, MELDNa is a simple method to identify at-risk patients at baseline and follow-up.
Maternal Toxoplasma gondii infection affects proliferation, differentiation and cell cycle regulation of retinal neural progenitor cells in mouse embryo
Authors: Campos Viviane Souza de , Magalhães Camila Feitosa , da Rosa Barbara Gomes , dos Santos Carolina Moreira , Fragel-Madeira Lucianne , Figueiredo Danniel Pereira , Calaza Karin C. , Adesse Daniel 
Published: July 2023

BackgroundToxoplasmosis affects one third of the world population and has the protozoan Toxoplasma gondii as etiological agent. Congenital toxoplasmosis (CT) can cause severe damage to the fetus, including miscarriages, intracranial calcification, hydrocephalus and retinochoroiditis. Severity of CT depends on the gestational period in which infection occurs, and alterations at the cellular level during retinal development have been reported. In this study, we proposed a mouse CT model to investigate the impact of infection on retinal development.MethodsPregnant females of pigmented C57BL/6 strain mice were infected intragastrically with two T. gondii cysts (ME49 strain) at embryonic day 10 (E10), and the offspring were analyzed at E18.ResultsInfected embryos had significantly smaller body sizes and weights than the PBS-treated controls, indicating that embryonic development was affected. In the retina, a significant increase in the number of Ki-67-positive cells (marker of proliferating cells) was found in the apical region of the NBL of infected mice compared to the control. Supporting this, cell cycle proteins Cyclin D3, Cdk6 and pChK2 were significantly altered in infected retinas. Interestingly, the immunohistochemical analysis showed a significant increase in the population of β-III-tubulin-positive cells, one of the earliest markers of neuronal differentiation.ConclusionsOur data suggests that CT affects cell cycle progression in retinal progenitor cells, possibly inducing the arrest of these cells at G2/M phase. Such alterations could influence the differentiation, anticipating/increasing neuronal maturation, and therefore leading to abnormal retinal formation. Our model mimics important events observed in ocular CT.
A Qualitative Exploration on Perceived Socio-Cultural Factors Contributing to Undernutrition Among Under-Fives in the Southern Highlands of Tanzania
Authors: Frumence Gasto , Jin Yannan , Kasangala Amalberga A. , Mang’enya Mary A. , Bakar Saidah , Ochieng Bertha 
Published: July 2023

Objective: Under nutrition especially among under-fives is a major public health challenge in Tanzania. However, the contribution of cultural practices to child under nutrition is often overlooked. This study aimed to explore the perceived socio-cultural factors contributing to the persisting under nutrition among under-fives in Tanzania.Methods: The study applied focus group discussion (FDGs) with forty practitioners to examine the sociocultural factors contributing to under nutrition during early childhood. The study participants were purposively selected and thematic analysis was used to identify themes within the data.Results: This study revealed that, under nutrition for under-fives is caused by a number of socio-cultural factors including existence of gender inequality related to dietary practices and qualities, women’s excessive workload, patriarchy social-norm, excessive alcohol use and cultural taboos prohibiting women and girls from eating certain types of nutrient dense foods.Conclusion: The study highlights the multiplicity of factors including socio-cultural perspectives contributing to under nutrition among under-fives, and calls for a concerted efforts in developing and implementing issue-specific and culturally sensitive strategies towards elimination of child under nutrition.
PENGARUH BUDAYA KERJA, DISIPLIN KERJA DAN KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING TERHADAP KINERJA ASN PADA KANTOR SEKRETARIAT DAERAH KABUPATEN POLEWALI MANDAR
Authors: Ismail Kaharullah - , Maryadi Maryadi , Asri Asri 
Published: July 2023

This study aims to analyze the effect of motivation, commitment and leadership style partially and simultaneously on employee work discipline and to analyze the variables that have the most dominant influence on the Department of Agriculture and Food, Polewali Mandar Regency.
The research used in this study is a quantitative research method. The population in this study were employees of Agriculture and Food Office of Polewali Mandar Regency, totaling 114 civil servants. Sampling of this study was carried out using the slovin technique with a significant standard of 5%. Thus, it can be seen that the sample used in this study were employees of Agriculture and Food Office of Polewali Mandar Regency totaling 89 respondents. The data collection technique was carried out through a questionnaire/questionnaire where each respondent's answer was assessed using a score according to the Likert scale.
The results of this study indicate that the results of the F test or simultaneous testing indicate that the Fcount value is 36.711 and Ftable is 2.71. So it shows that Fcount > Ftable with a significance of 0.000 < 0.05. These results indicate that motivation, commitment and leadership style simultaneously have a significant effect on the work discipline of the employees of the Department of Agriculture and Food, Polewali Mandar Regency. From the description of the t test, it is known that motivation, commitment and leadership style partially each have a positive and significant effect on the work discipline of the employees of the Department of Agriculture and Food, Polewali Mandar Regency. Furthermore, the motivation variable is the most dominant influencing variable with a beta value of 0.512.
NONALCOHOLIC FATTY LIVER DISEASE AND ALBUMINURIA : A SYSTEMATIC REVIEW
Authors: Nur Amelia Devita 
Published: July 2023

Background: The presence of fat storage in the liver that is larger than 5% of the liver's weight is diagnostic of nonalcoholic fatty liver disease (NAFLD), which can occur in the absence of excessive alcohol consumption or a secondary cause of liver illnesses. It is interesting to note that it has been hypothesised that NAFLD might be able to contribute to albuminuria by exacerbating the endothelial dysfunction that results from systemic inflammation.
Aim: This article examines the link between nonalcoholic fatty liver disease and albuminuria.
Methods: This study showed that it met all of the requirements by looking at the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines. So, the experts could make sure that the study was as current as possible. The search method used a number of electronic reference databases, such as Pubmed and SagePub, to look for papers that were published between 2000 and 2023. We didn't look at review papers, articles that had already been published, or articles that were only half done.
Result: In the PubMed database, the results of our search brought up 89 articles, whereas the results of our search on SagePub brought up 33 articles. The results of the search conducted for the last year of 2013 yielded a total of 22 articles for PubMed and 16 articles for SagePub. In the end, we compiled a total of 17 papers, 12 of which came from PubMed and five of which came from SagePub. We included seven research that met the criteria.
Conclusion: Study has consistently shown that there is a correlation between NAFLD and albuminuria.
TUBERCULOSIS IN LIVER TRANSPLANT RECIPIENT : A SYSTEMATIC REVIEW
Authors: Nur Amelia Devita 
Published: July 2023

Background: Despite claims, transplant recipients' TB rates are random. The rate of posttransplant tuberculosis depends on the organ transplanted, pre-transplant latent tuberculosis screening, and previous antituberculosis medication. This rate may also depend on recipient and donor tuberculosis rates. Active tuberculosis after solid organ transplantation increases the risk of graft loss and death four-fold compared to the general population.
Aim: This article examines the link between tubercolis and liver transplant recipient.
Methods: This study showed that it met all of the requirements by looking at the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 guidelines. So, the experts could make sure that the study was as current as possible. The search method used a number of electronic reference databases, such as Pubmed and SagePub, to look for papers that were published between 2000 and 2023. We didn't look at review papers, articles that had already been published, or articles that were only half done.
Result: In the PubMed database, the results of our search brought up 66 articles, whereas the results of our search on SagePub brought up 23 articles. The results of the search conducted for the last year of 2013 yielded a total of 23 articles for PubMed and 18 articles for SagePub. In the end, we compiled a total of 20 papers, 16 of which came from PubMed and four of which came from SagePub. We included five research that met the criteria.
Conclusion: Patients who have undergone organ transplantation are at high risk of developing latent TB. This shows the importance of administering prophylactic drugs such as isoniazid in post-liver transplant patients.
Stealthing
Authors: Swier B.C. (Bart) 
Published: July 2023

Stealthing
Wat is stealthing, is het (al) een strafbaar feit en zo ja en zo nee, moet het in de toekomst (ook) als verkrachting worden gekwalificeerd? In deze bijdrage zal aan de hand van de recente vervolging van twee verdachten ter zake van stealthing worden beargumenteerd dat het buitengewoon wenselijk is als de wetgever ondubbelzinnig besluit of stealthing een zedenmisdrijf behoort te zijn en zo ja, onder wat voor omstandigheden en met welke strafbedreiging.
El vínculo entre el rol docente y el uso crítico de proyectos interdisciplinarios patrimoniales en la Educación Primaria: un estudio de caso de una localidad de Cataluña
Authors: Callarisa Joan , Sabido-Codina Judit 
Published: July 2023

This article aims to analyze the effect of a primary school teacher’s daily work with an interdisciplinary project related to heritage on the reflective transformation of students. The research, of a longitudinal nature and with hermeneutical interpretative foundations, is a case study conducted in a primary school in a town in the Autonomous Community of Catalonia. The data were collected from non-participatory observation and interviews and structured around four dimensions of analysis: 1) environment, heritage and school open to the world, 2) interaction and construction of knowledge, 3) educational purposes and education for citizenship, and 4) the teaching role. The qualitative data were then corroborated with the free software Iramuteq. The results revealed (i) the relevance of teachers as agents of educational change in the critical formation of students; and (ii) how heritage can be an ideal backbone of interdisciplinary projects.
En el presente artículo pretendemos analizar la transformación reflexiva del alumnado a la que contribuye una maestra de educación primaria en el aula a partir de su trabajo diario con un proyecto interdisciplinario relacionado con el patrimonio. La investigación de carácter longitudinal y con fundamentos interpretativos hermenéuticos se caracteriza por ser un estudio de caso de una escuela de primaria de una localidad de Cataluña. Los datos recopilados a partir de la observación no participativa y las entrevistas se estructuraron en torno a cuatro dimensiones de análisis: 1) medio, patrimonio y escuela abierta al mundo, 2) interacción y construcción del conocimiento, 3) finalidades educativas y educación para la ciudadanía y 4) el rol docente. Seguidamente se corroboraron los datos cualitativos con el software libre Iramuteq. Los resultados han manifestado principalmente la relevancia de los docentes como agente del cambio educativo en la formación crítica de los estudiantes y han demostrado como el patrimonio puede ser un idóneo eje vertebrador de los proyectos interdisciplinarios.
Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone
Authors: Li Linlin , Permana Andi Dian , Domínguez‐Robles Juan , Amir Muh Nur , Habibie Habibie , Anjani Qonita Kurnia , Zhao Li , Moreno‐Castellanos Natalia , Donnelly Ryan F , Larrañeta Eneko 
Published: January 2025

AbstractImplantable drug delivery systems are crucial for achieving sustained delivery of active compounds to specific sites or systemic circulation. In this study, a novel reservoir‐type implant combining a biodegradable rate‐controlling membrane with a drug‐containing core prepared using direct compression techniques is developed. The membrane is composed of poly(caprolactone) (PCL), and risperidone (RIS) served as the model drug. Characterization of both membranes and direct compressed pellets includes hardness testing, optical coherence tomography, mercury intrusion porosimetry, and surface morphology observation. In vitro release studies of RIS reveal that higher drug loading in the pellets extended‐release duration up to 70 days when incorporated into membranes with four layers. Increasing the number of membrane layers slows the release rate further, ranging from 70 to 170 days depending on membrane thickness. Biocompatibility studies demonstrate that these implantable devices are non‐toxic and biocompatible with cells in vitro. In vivo studies conduct in male Wistar rats demonstrate sustained release of RIS, with plasma levels showing a significant increase post‐implantation at a relatively constant rate for up to 49 days. These results indicate that the developed implants have the potential to provide long‐acting drug delivery to the systemic circulation.
Perovskite‐Based Smart Eyeglasses as Noncontact Human–Computer Interaction
Authors: Hu Yuming , Wu Tingqing , Guo Haole , Xie Hongfei , Chen Sisi , Chen Sihan , Xue Tangyue , Guo Lutong , Wang Liwei , Pan Qi , Zhang Zeying , Wang Huadong , Lian Zewei , Han Teng , Song Yanlin , Su Meng 
Published: January 2025

AbstractMore than 70% of human information comes from vision. The eye is one of the most attractive sensing sites to collect biological parameters. However, it is urgent to develop a cost‐effective and easy‐to‐use approach to monitor eyeball information in a minimally invasive way instead of current smart contact lenses or camera‐based eyeglasses. Here, the biomimetic mineralization strategy is developed to prepare large‐grained perovskite film on the glass with prepared ITO electrodes, which displays the on–off ratio close to 300 times at 500 Lux light intensity, and the responsiveness reaches 22.09 A W−1. The smart eyeglasses composed of perovskite‐based photodetectors can directly convert the visual stimuli from the reflective light of eyeballs into electrical signals in all light circumstances. After scaling up the pretraining data and the model size, the smart eyeglasses achieve the noncontact monitoring of the eyeball movement with the recognition angle of 5°, which can be used to unobtrusively drive the model car with great freedom. The smart eyeglasses based on the perovskite photodetectors provide cost‐effective approaches for monitoring eyeball movements, which will show great potential in the applications of man‐machine control, augmented reality, individual healthcare, etc.
Paradigm Enhancement of White‐Light Responsive NIR‐II Photoluminescence via Toroidal Energy Migration
Authors: Liu Haikuo , Dai Mengmeng , Li Kejie , Xu Hanyu , Wei Yanling , Fu Zuoling 
Published: January 2025

AbstractNear‐infrared II (NIR‐II, 1000–1700 nm) lanthanide‐doped fluorescent probes provide a powerful new tool for existing clinical biomedical sensing and imaging. However, it is impeded in practical applications by its specific high‐energy laser source. Herein, a white‐light responsive Ce3+‐mediated toroidal energy migration downshifting topological core–shell structure NIR‐IIb (1500–1700 nm) fluorescent probe is reported. It is found that Ce3+ doping enhances the NIR downshifting luminescence of the Ho3+ and Nd3+, thereby increasing the energy‐transferred Yb3+ luminescence. The NaCeF4 core is able to further facilitate the crossrelaxation between the intermediate‐shell layer of Er3+ and Ce3+ through the outward‐to‐inward core–shell topology, enhancing the 1527 nm luminescence to form the toroidal energy migration paradigm. Additionally, the luminescence of Er3⁺ exhibits strong temperature dependence, enabling superior temperature sensing under multiple light sources. Under low‐power white light source, the relative sensitivity (Sr) can reach up to 0.57% K−1, with a minimum temperature uncertainty (δT) of 0.2 K. Moreover, portable light conversion using highly efficient white‐light responsive emission in NIR‐II region enables noninjectable intravenous imaging and food inspection. This toroidal energy migration strategy provides a new direction for lanthanide energy harvesting and multisource NIR applications.
Nitrogen‐Oxygen Co‐Functionalized Waste Cassava Peel‐Derived Carbon Dots for White Led
Authors: George Jelby , Balachandran Manoj 
Published: January 2025

AbstractWhite light emitting diodes (WLEDs) are most sought after, with the broad spectra ranging from cool to warm white light being skillfully utilized to create various modes of lighting effects. The fabrication of WLEDs is generally sophisticated, involving either multiple components emitting in different regions or single‐component phosphors with complex elemental compositions. In the present work, WLEDs utilizing solvent‐tuned carbon dots derived from waste cassava peel are reported through a facile one‐step microwave‐assisted solvothermal method. The carbon dots show evident UV absorption and correspondingly emit broad visible light spectra when dispersed in a dimethylformamide (DMF)‐polyvinyl alcohol (PVA) blend, making themselves suitable white light–emitting down conversion materials. The successful transformation of a 400 nm UV LED into a WLED with a general colour rendering index (CRI) of 83 and colour correlation temperature (CCT) of 4426 K gives a promising future outlook toward developing eco and economic‐friendly WLEDs.
Thermoelectric Performance Predictions Combining Experiments with Multi‐Band Modelling
Authors: Agrawal Bharti , Dasgupta Titas 
Published: January 2025

AbstractThe search for high‐performance thermoelectric (TE) materials requires accurate property predictions and the development of analytical models to mimic the temperature dependent charge and heat transport in semiconductors. This is a non‐trivial task as most thermoelectric materials have complex electronic band structures with multiple bands contributing to charge transport. In this work, it is shown that using a combination of experiments and a recently developed multi‐band modelling technique, it is possible to accurately predict the temperature and doping dependent properties of TE materials. The steps involved are experimental data collection, model parameter generation, and data interpolation. The methodology is elaborated using the example of Mg2Si0.3Sn0.7 which is a high‐performance, low‐cost thermoelectric material. 3‐D maps of power factor and thermoelectric figure of merit () are generated as a function of temperature and doping concentration. Model validation is carried out for a randomly prepared composition which yields maximum deviations of ±10% in the and the power factor plots. The results highlight the potential of this tool for rapid screening of high‐performance compositions.
Electronic Structure Modulation in N, P, S Tri‐Doped Nanofibers with Interpenetrated Pores for Enhanced Oxygen Reduction Reaction
Authors: Xu Xiao , Wu Hongliang , Yan Yan , Zheng Yong , Yan Yusheng , Qiu Siqi , Liang Tao , Deng Chenyuan , Yao Yuechao , Zou Jizhao , Liu Mingkai 
Published: January 2025

AbstractMulti‐heteroatom‐doped metal‐free carbons with well‐tailored electronic structures are regarded as promising oxygen reduction reaction (ORR) catalysts. However, their active sites are often hindered by the carbon matrix, resulting in reduced catalytic activity. Herein, nitrogen, phosphorus, and sulfur tri‐doped hollow hierarchical porous carbon nanofibers (NPS‐HPCNFs) with interpenetrated pores are synthesized using a facile coaxial electrospinning method. The distinctive steric confinement induced by the interpenetrated pores created a positive microenvironment for the ORR. As a result, the resultant NPS‐HPCNF catalyst exhibits a half‐wave potential (E1/2) of 0.86 V (vs. RHE) and superb long‐term stability in 0.1 m KOH. Furthermore, the zinc‐air battery (ZAB) assembled with NPS‐HPCNF achieves a great peak power density of 210 mW cm−2 and a superior specific capacity of 795 mAh g−1, outperforming the commercial Pt/C candidate. In addition, density functional theory (DFT) calculations reveal that the synergistic effect of the N, P, S tri‐doping combined with defect sites effectively regulated the electronic structure and significantly enhanced the *OOH adsorption, thus accelerating the ORR process. Therefore, the tri‐doped carbon nanofibers with abundant interpenetrated pores represent a promising and eco‐friendly alternative to state‐of‐the‐art Pt/C electrocatalysts for various electrochemical energy applications.