bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Development or Economic Development: The Dilemma Behind an Ambitious Infrastructure Development
Authors: Hasidin Mirza Hapsari , Nugrahanti Trinandari Prasetyo , Huda Imam Walid Asrofuddin Ulil , Bajuri Ahmad , Helmayuni Helmayuni 
Published: December 2022

Abstract The construction of the One Belt One Road (OBOR) infrastructure is a reasonably ambitious development. However, at the same time, there are several dilemmas faced by the Indonesian government. This research will examine the potential and obstacles to the ambitious OBOR infrastructure development in Indonesia. This research will be carried out using a qualitative approach. The data used in this study comes from previous research and studies that still have the same discussion as this research. This study found that OBOR infrastructure development can potentially increase the connectivity of waters in Indonesian territory. This will lead to an even social and economic development distribution throughout Indonesia. However, at the same time, several dilemmas need to be faced by the Indonesian government in building OBOR infrastructure. Keywords: One Belt One Road (OBOR), Development, Infrastructure. Abstrak Pembangunan infrastruktur One Belt One Road (OBOR) merupakan pembangunan yang cukup ambisius. Namun, pada saat yang sama, ada beberapa dilema yang dihadapi pemerintah Indonesia. Riset ini akan mengkaji potensi dan hambatan pembangunan infrastruktur OBOR yang ambisius di Indonesia. Penelitian ini akan dilakukan dengan menggunakan pendekatan kualitatif. Data yang digunakan dalam penelitian ini berasal dari penelitian sebelumnya dan penelitian yang masih memiliki pembahasan yang sama dengan penelitian ini. Kajian ini menemukan bahwa pembangunan infrastruktur OBOR berpotensi meningkatkan konektivitas perairan di wilayah Indonesia. Hal ini akan mengarah pada pemerataan pembangunan sosial dan ekonomi di seluruh Indonesia. Namun, pada saat yang sama, beberapa dilema perlu dihadapi pemerintah Indonesia dalam membangun infrastruktur OBOR. Kata kunci: One Belt One Road (OBOR), Pembangunan, Infrastruktur.
Analisis Sosial Peran Lembaga Dakwah Sebagai Media Komunikasi Pada Masyarakat
Authors: Hafniati Hafniati 
Published: December 2022

AbstractThe purpose of this study was to analyze the role of da'wah institutions as a medium of communication in a sociological review. The methodology used is qualitative research with studies of figures/institutions. The study of figures/institutions uses methods, namely interviews, observations, documentation, literature, and notes on the life journey of the figures/institutions. This study shows the results that the more media used the easier communication in da'wah. The current da'wah movement requires more than tablgh aspects, which is only to convey invitations with fardiyah (personal) media without being supported by social entities in the form of legal legal entities. Guidance requires diâfan (defense) in the form of a legal entity as a logical consequence of the concept of imamah, shura, congregation, community (qaryah taiyibah), and others. This is caused by humans as social beings, so that their interactions are not limited to individual matters, but also concerns the needs of many people, which in this case can be in the form of constitutional munkar or unfair political policies. The AFKN Foundation is a social institution that is engaged in da'wah, education, social and human resource development. This institution was founded by Ustadz Fadzlan Garamatan as one of his propaganda media.Keywords: Role, Da'wah Institution, Media, Communication. AbstrakTujuan penelitian ini adalah menganalisis peran lembaga dakwah sebagai media komunikasi dalam tinjauan sosiologi. Metodologi yang digunakan adalah penelitian kualitatif dengan kajian tokoh/lembaga. Studi tokoh/lembaga menggunakan metode yakni wawancara, observasi, dokumentasi, literatur, dan catatan-catatan perjalanan hidup sang tokoh/lembaga. Penelitian ini menunjukan hasil bahwa semakin banyak media yang digunakan semakin memudahkan komunikasi dalam dakwah. Gerakan dakwah saat ini membutuhkan lebih dari aspek tablîgh, yaitu hanya menyampaikan ajakan saja dengan media fardiyah (personal) tanpa didukung oleh entitas sosial berupa lembaga berbadan hukum yang legal. Binaan (membina) membutuhkan adanya diʻâfan (pertahanan) yang berbentuk badan hukum sebagai konsekuensi logis dari konsep imamah, syura, jamaah, komunitas (qaryah taiyibah), dan lain-lain. Hal ini disebabkan oleh manusia sebagai makhluk sosial, sehingga interaksinya tidak sebatas pada hal-hal individu, tapi juga menyangkut hajat orang banyak yang dalam hal ini wujudnya bisa berupa kemungkaran konstitusi atau kebijakan politik yang tidak adil. Yayasan AFKN merupakan lembaga kemasyarakatan yang bergerak di bidang dakwah, pendidikan, sosial dan pengembangan sumber daya manusia. Lembaga ini didirikan oleh ustadz Fadzlan Garamatan sebagai salah satu media dakwahnya.Kata Kunci: Peran, Lembaga Dakwah, Media, Komunikasi.
Délimiter l’espace des alternatives dans l’enseignement public
Authors: Allam Marie-Charlotte 
Published: December 2022

Dans un contexte d’accroissement de l’offre éducative privée, cet article interroge les logiques politiques et institutionnelles qui président à l’ouverture – ou à la fermeture – de l’espace des alternatives pédagogiques dans l’enseignement public français. Il analyse l’activité de deux institutions en charge de l’innovation au sein du ministère de l’Éducation nationale entre 2000 et 2002 : le Conseil national de l’innovation pour la réussite scolaire (CNIRS), institution consultative naissante, et le bureau Innovalo qui occupe une position stratégique dans l’administration centrale. Adoptant une perspective de sociologie de l’institution, le texte restitue la genèse, les enjeux et le dénouement de leur concurrence pour le monopole de la politique d’innovation. Les luttes de territoire entre celles-ci ont un effet à la fois sur la définition de la politique d’innovation pédagogique et sur le devenir des expériences pédagogiques alternatives : si le CNIRS disparaît après 2002, sa stratégie de publicisation lui assure une influence durable et une intégration de ses instruments par le bureau Innovalo.
Diagnostics critiques et remèdes pédagogiques des « prestataires de l’égalité des chances » vis-à-vis de l’École
Authors: Pavie Alice 
Published: December 2022

Les discours critiques vis-à-vis de l’École sont souvent présentés comme émanant de deux camps politiques distincts. L’un, réformiste, prône une modernisation de l’institution scolaire, l’autre, conservateur, un retour à une école républicaine mythifiée. Cet article propose de questionner cette division binaire à partir d’une enquête auprès d’acteurs associatifs : les « prestataires de l’égalité des chances ». Leur activité consiste à accompagner des élèves scolarisé·es en éducation prioritaire et défini·es comme « méritant·es ». Ils partagent l’idée que l’École, seule, n’est pas à même de garantir leur réussite, mais ils revendiquent des diagnostics et remèdes contrastés. Leurs approches se distinguent selon deux dimensions : l’une relative à leur vision de ce que devraient être les relations École/société, l’autre à leur lecture des carences du système scolaire. Leur croisement permet d’analyser quatre modèles pédagogiques caractérisant les associations enquêtées et d’esquisser une autre grille de lecture des discours critiques à l’encontre de l’École.
Devenir « fondateur d’école » : un processus de valorisation de l’alternative scolaire privée
Authors: Legavre Amélia 
Published: December 2022

Sur la base d’entretiens conduits avec vingt fondateurs d’école hors contrat, l’article met en avant la valorisation de l’alternative scolaire privée en tant que processus accompagnant le choix de fonder une école. Comment des individus a priori éloignés du monde de l’enseignement privé alternatif en viennent-ils à s’engager dans cette voie professionnelle ? Les récits de fondateurs d’école mettent en évidence trois étapes marquant le processus de l’entrée dans cette carrière : une mise en doute de la pédagogie traditionnelle ; une découverte d’autres options éducatives ; une concentration sur les bienfaits de l’initiative privée locale pour la cause de l’éducation.
Tenir le rôle de Gilet jaune en Belgique : conditions d’un militantisme démocratique transnational
Authors: Petit Guillaume 
Published: December 2022

Cet article décentre et prolonge la recherche sur le mouvement des Gilets jaunes (GJ) pour s’intéresser à des individus se revendiquant GJ en Belgique. À travers ce cas limite, il analyse les conditions d’une singularité : le déclenchement et le maintien d’un engagement transnational dans un contexte de faible mobilisation nationale. Il se fonde sur une enquête pluri-méthodique, à partir d’observations, suivi en ligne, focus groups et entretiens. L’article dégage trois formes d’engagement, désespéré, altruiste et déclassé. Il note comment on devient GJ de ou en Belgique, mais aussi en quoi l’accès aux actes parisiens agit comme un rite d’initiation. À l’échelle des individus, c’est par la performance d’un rôle qu’un militantisme démocratique, post-institutionnel et anti-représentatif, se maintient sur le temps long. Enfin, l’article met en lumière le devenir de symbole politique du GJ comme accessoire individualisé et signifiant, disponible au-delà de son contexte d’origine.
Sub-cellular sequestration of alkaline drugs in lysosomes
Authors: Yousef Malaz , Le Tyson S. , Zuo Jieyu , Park Chulhun , Chacra Nadia Bou , Davies Neal M. , Löbenberg Raimar 
Published: December 2022

Background and purpose:
Lysosomal-targeted drug delivery can open a new strategy for drug therapy. However, there is currently no universally accepted simulated or artificial lysosomal fluid utilized in the pharmaceutical industry or recognized by the United States Pharmacopeia (USP).

Experimental procedure:
We prepared a simulated lysosomal fluid (SLYF) and compared its composition to a commercial artificial counterpart. The developed fluid was used to test the dissolution of a commercial product (Robitussin®) of a lysosomotropic drug (dextromethorphan) and to investigate in-vitro lysosomal trapping of two model drugs (dextromethorphan and (+/-) chloroquine).

Findings/Results:
The laboratory-prepared fluid or SLYF contained the essential components for the lysosomal function in concentrations reflective of the physiological values, unlike the commercial product. Robitussin® passed the acceptance criteria for the dissolution of dextromethorphan in 0.1 N HCl medium (97.7% in less than 45 min) but not in the SLYF or the phosphate buffer media (72.6% and 32.2% within 45 min, respectively). Racemic chloroquine showed higher lysosomal trapping (51.9%) in the in-vitro model than dextromethorphan (28.3%) in a behavior supporting in-vivo findings and based on the molecular descriptors and the lysosomal sequestration potential of both.

Conclusion and implication:
A standardized lysosomal fluid was reported and developed for in-vitro investigations of lysosomotropic drugs and formulations.
Synthesis of oxamide-hydrazone hybrid derivatives as potential anticancer agents
Authors: Dehbid Mina , Tahmasvand Raheleh , Tasharofi Marzieh , Shojaie Fatemeh , Aghamaali Mahmoudreza , Almasirad Ali , Salimi Mona 
Published: December 2022

Background and purpose:
Considering various studies implying anticancer activity of the hydrazone and oxamide derivatives through different mechanisms such as kinases and calpain inhibition, herein, we report the synthesis, characterization, and evaluation of the antiproliferative effect of a series of hydrazones bearing oxamide moiety compounds (7a-7n) against a panel of cancer cell lines to explore a novel and promising anticancer agent (7k).

Experimental approach:
Chemical structures of the synthesized compounds were confirmed by FTIR, 1H-NMR, 13C-NMR, and mass spectra. The antiproliferative activity and cell cycle progression of the target compound were investigated using the MTT assay and flow cytometry.

Findings/Results:
Compound 7k with 2-hydroxybenzylidene structure was found to have a significant in vitro anti-proliferative influence on MDA-MB-231 (human adenocarcinoma breast cancer) and 4T1 (mouse mammary tumor) cells as the model of triple-negative breast cancer, with the IC50-72h values of 7.73 ± 1.05 and 1.82 ± 1.14 μM, respectively. Following 72-h incubation with compound 7k, it caused MDA-MB-231 cell death through G1/S cell cycle arrest at high concentrations (12 and 16 μM).

Conclusion and implications:
Conclusively, this study for the first time reports the anti-proliferative efficacy of compound 7k possessing 2-hydroxyphenyl moiety, which may serve as a potent candidate in triple-negative breast cancer treatment.
The effectiveness of colistin/levofloxacin compared to colistin/meropenem in the treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii
Authors: Momenzadeh Mahnaz , Soltani Rasool , Shafiee Fatemeh , Hakamifard Atousa , Pourahmad Morteza , Abbasi Saeed 
Published: December 2022

Background and purpose:
The treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) is still a great challenge. This study evaluated the effectiveness of the colistin/levofloxacin regimen compared to the usual colistin/meropenem regimen in the treatment of patients with VAP caused by CRAB.

Experimental approach:
The patients with VAP were randomly assigned to experimental (n = 26) and control (n = 29) groups. The first group received IV colistin 4.5 MIU every 12 h + levofloxacin 750 mg IV daily, and the second group received IV colistin with the same dose + meropenem 1 g IV every 8 h for 10 days. The clinical (complete response, partial response, or treatment failure) and microbiological responses at the end of the intervention were recorded and compared between the two groups.

Findings/Results:
The complete response rate was higher (n = 7; 35%) and the failure rate was lower (n = 4; 20%) in the experimental group than in the control group (n = 2; 8%, and n = 11; 44%, respectively), but the differences were not statistically significant. Even though the microbiological response rate was higher in the experimental group (n = 14; 70%) than in the control group (n = 12; 48%), the difference was not statistically significant. The mortality rate was 6 (23.10%) and 4 patients (13.8%) in the experimental and control groups, respectively (P = 0.490).

Conclusion and implication:
The levofloxacin/colistin combination can be considered an alternative regimen to meropenem/colistin in the treatment of VAP caused by CRAB.
In vivo electrophysiological study of vitamin D3 protective effects on PTZ-induced seizures in rats
Authors: Gharehaghaji Sara Hosseinchi , Panahi Yousef , Khalilzadeh Emad , Saiah Gholamreza Vafaei 
Published: December 2022

Background and purpose:
The purpose of the current study was to investigate the protective effects of acute and chronic administration of different doses of vitamin D3 on pentylenetetrazol (PTZ)-induced epileptiform activities in rats.

Experimental approach:
Sixty Wistar rats in chronic and acute groups were used in this study. In the chronic groups, animals received vitamin D3 at 50, 100, and 150 μg/kg; vitamin D3 (50 μg/kg, i.p.) + diazepam (0.1 mg/kg, i.p.), and almond oil (i.p.) daily for two weeks whereas, in the acute groups the animal received a single dose of chemicals just 30 min before PTZ administration. The electrophysiological recording was performed by implanting a unilateral bipolar electrode in the pyramidal cell layer of the CA1 region of the hippocampus. Epileptic activities were induced by intraperitoneal injection of PTZ (80 mg/kg, i.p.). The spike count and amplitude were analyzed using the eTrace software.

Finding/Results:
Chronic administration of all doses of vitamin D3 and its combination with diazepam significantly reduced both spike counts and amplitudes following PTZ administration. While the acute doses were ineffective.

Conclusion and implication:
The results of the study indicated that chronic but not acute administration of vitamin D3 has a protective effect on PTZ-induced epileptiform activity in rats.
Role of duplex-guided infragenicular angioplasty in saving limbs
Authors: Elimam Sameh E. , Shereif Hala M. 
Published: December 2022

Background/aim
Critical limb ischemia (CLI) is known as ischemic rest pain at rest or tissue loss with peripheral arterial disease. Endovascular intervention has many advantages than surgical bypasses and it is used frequently with fragile patients, at the same time, it has many adverse effects for both surgeon and patient such as radiation effect for both and renal-induced nephropathy for the patient. Worldwide duplex-guided infragenicular angioplasty is a new method that has been started to emerge and to be a common technique in such patients, That is why the present study aims to assess the feasibility and efficacy of duplex-guided infragenicular angioplasty to save limbs and to detect if it is applicable or not.

Patients and methods
Twenty CLI patients were admitted to the vascular unit from 2015 to 2017 in Al-Zahraa University Hospital, Al-Azhar University, Cairo, Egypt. We included patients with good femoral pulse and significant infragenicular lesions. We excluded those with proximal outflow lesions and with acute embolic or thrombotic insults. Percutanous transluminal angioplasty was done to all the patients through ipsilateral femoral access by using 0.014 and 0.018 wires 4 F catheters and low-profile balloons, then we followed them clinically and with duplex ultrasound at 1, 3, 6, and 12 months with calculating the hemodynamic studies.

Results
The present study enrolled 20 patients, six (30%) of them are females and 14 (70%) males, with mean age of 59.2. The clinical history of smokers, cardiac, diabetics, renal, and hypertensive were 65, 60, 50, 85, and 80%, respectively. Technical success was 90%. Groin hematoma, distal thrombosis, and vessel perforation were technical complications, with 5% for each. Optimal procedural success was achieved in 70%, of suboptimal in 20%, and then we failed in 10%. Rest paint completely disappeared from 75% of patients. Sixteen limbs were saved postintervention, Kaplan–Meier curve showed 70% survival rate at 6 months, while at 9 months, the drop occurred to be 28%, which was still to be the percent at 12 months.

Conclusion
Modern duplex ultrasound can be used to map the arterial disease and to show guide wires, sheaths, balloons, and stents for the treatment of infragenicular arterial lesions. Also, it seems to be safe, easy and effective technique, a bedside procedure, and cost-effective as well. It has a crucial role in saving limbs for CLI patients.
Color stability of heat polymerized complete dentures and 3D printed CAD/CAM dentures
Authors: El Naggar Shady M. , Helal Eman , Khalil Maie F. , Esmat Ahmed M. , Elboraey Asmaa N. 
Published: December 2022

Background/aim
Color stability of complete dentures is one of the most significant aspects that affect the success of complete dentures (CD) and improve the patient’s quality of life. Therefore, the present clinical crossover research targeted to assess and compare the color stability of conventional heat-polymerized polymethyl methacrylate (PMMA) CDs and three-dimensional (3D)-printed dentures and their effect on the ‘oral health-related quality of life’ (OHRQoL).

Patients and methods
Twenty completely edentulous patients aged from 45 to 75 received two sets of CDs. The first denture set was polymethyl methacrylate CD (group I), and the patients were instructed to use it for 3 months. Then after 3 months, the patients were instructed to wear the 3D-printed CD set (group II) and use it for another 3 months. The color change of the CD’s base was evaluated at denture insertion after 1 and 3 months using a spectrophotometer. The ‘OHRQoL ’ was used to assess patient satisfaction at the end of the treatment of every denture set. Statistical analysis was accomplished through an independent t test and one-way analysis of variance.

Results
Regarding the color change of the CD denture base at denture insertion, there was an insignificant distinction between group I and group II (P>0.05). While after 1 and 3 months, group I showed a significant increase in the color change when compared with group II (P<0.05). When comparing the color change in each group during the different follow-up periods, the color change was significantly increased in both groups (P<0.05). In terms of ‘OHRQoL,’ there was a significant distinction between group I and group II (P<0.05). Group II (18.89) scored less than group I (43.42).

Conclusion
3D-printed CDs exhibit good color stability when compared with conventional CDs. The OHRQoL revealed that 3D-printed CDs have more patient satisfaction than conventional CDs.
Immunohistochemical expression of CD8+ tumor-infiltrating lymphocytes and Foxp3 expression in colorectal carcinoma
Authors: Hammad Shaimaa Y. , Awadallah Hala I. , Badawi Manal A. , Shaffie Nermeen M. , Salah Heba A.M. , Abouelfadl Dalia M. 
Published: December 2022

Background/aim
Colorectal cancer (CRC) is third among diagnosed tumors (6.1%) and second according to mortality (9.2%). Disease prognosis is determined not only by the histologic and molecular features of the tumor but also by the host response. Histologic distributions of tumor-infiltrating lymphocytes (TIL) in the microenvironment can be correlated with staging and prognosis of CRC patients. Abundance of CD8+ T lymphocytes has been associated with good prognosis in different types of solid tumors. The association between tumor cell expression of FoxP3 and tumor infiltration by FoxP3-expressing T lymphocytes with prognosis is still controversial. The aim of this study is to evaluate CD8+ TILs and expression of FoxP3 in CRC and to correlate their expression with patients’ clinicopathological parameters.

Materials and methods
Tumor paraffin blocks and clinicopathological data of 60 patients with CRC were obtained from the Pathology Department at Cairo University. The density of CD8 TILs and FoxP3 expression was assessed immunohistochemically and evaluated by image analysis in CRC specimens using area percentage parameter. The CD8+ cell tumor infiltrate and FoxP3 expression were classified into scanty, moderate, and abundant.

Results
CD8+ TIL in the present study was insignificantly correlated with the clinicopathological parameters, and no correlation was detected between FoxP3 and CD8 expression (P>0.05). However, FOXP3 expression was significantly correlated with tumor grade, nodal status, distant metastasis, tumor stage, and Dukes’ classification (P<0.01).

Conclusion
The presence of FoxP3 expression in CRC correlates with favorable pathological prognostic parameters. Cancer colon progression is influenced by host immune response. More studies are needed to assess the role of tumor microenvironment in CRC prognosis.