bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactivity of Cinnamomum verum powder and extract against Cryptolestes ferrugineus S., Rhyzopertha dominica F. and Sitophilus granarius L. (Coleoptera)
Authors: Mahmoud Hend A. , Azab Mohamed M. , Sleem Fatma M. A. 
Published: March 2023

AbstractThe world is heading to increase the productivity, quantity and quality, of basic crops, but the stored grain pests destroy all these efforts and reduce its quality. This study aims to assess activity of Cinnamomum verum powder and extract against Cryptolestes ferrugineus, Rhyzopertha dominica, and Sitophilus granarius. Residual film of cinnamon was tested with and without grains (as contact toxicity). Repellent activity was estimated by using choice chamber method and waved filter paper for powder and extract, respectively. There were significant differences among all tested insects. S. granarius was more affected with cinnamon extract than C. ferrugineus followed by R. dominica. LC50 values were 1.01, 1.37 and 3.13% at 24 h. While, C. ferrugineus was more affected with powder than S. granarius followed by R. dominica. For repellent activity, C. ferrugineus was the most affected with the powder and extract followed by R. dominica and S. granarius, where, the mean repellent percentages were 100, 98 and 82% for the powder and 86.94, 62.78 and 29.44% for the extract, respectively. The repellent percentage increased with increasing the concentration and the time of exposure. Cinnamon powder and extract can be used as insecticide against stored grain pests by easy way and safety to human and the environment.
Chemical composition, sources, and ecological effect of organic phosphorus in water ecosystems: a review
Authors: Feng Weiying , Wang Tengke , Zhu Yuanrong , Sun Fuhong , Giesy John P. , Wu Fengchang 
Published: March 2023

AbstractPhosphorus (P) affects the water–air CO2 flux through primary productivity, and affects the changes of carbon cycle and ecological environment in the global world. Organic phosphorus (Po) is an important P component in water environments. Various processes control the formation and transformation of Po and outbreaks of algal blooms. Here, research topics on Po in global water over the past 50 years are systematically reviewed to understand the progress in the (i) Po pretreatment techniques in various media, (ii) technical methods and qualitative and quantitative research on chemical composition of Po and bioavailability, (iii) source analysis of and factors affecting Po in different media of water environments and biogeochemical processes, (iv) interactions among Po, organic matter, and minerals, and their environmental behaviors, and (v) quantification of material exchanges at the sediment–water interface, interfacial processes, and ecological effects. Finally, the future research directives regarding Po in water environments are discussed. The findings provided an important scientific basis to formulate and revise global standards for water nutrients and a better understanding of water eutrophication and its control.
Graphical Abstract
Looking Ahead in the Rearview Mirror: During Action Review and Tabletop (DART) to Strengthen Health Emergency Readiness and Resiliency
Authors: McNeil Carrie , Divi Nomita , Smolinski Mark S. 
Published: March 2023

Abstract
During health emergencies, such as the COVID-19 pandemic, systematic evaluation of capabilities, and multisector coordination are challenging while operating in triage mode. During Action Review and Tabletop (DART) identifies recommendations for strengthening readiness and resiliency by creating a single methodology integrating retrospective analysis of the response to date with a prospective analysis of future scenarios. DART utilizes a role-based questionnaire and participant-led discussion for retrospective response review and identification of future scenarios of concern. Tabletop exercises exploring those future scenarios are conducted in a multi-role format to assess readiness and resiliency. Participants evaluate findings to determine recommended actions to improve response capabilities. 3 COVID-19 focused DARTs demonstrated the ability of this participant-led approach to systematically assess, not only readiness for today, but also resiliency to future complications. While demonstrating its usefulness during COVID-19, DART’s flexible and modular design promises to be an effective for any ongoing health emergency.
Time-lapse recording of yearly activity of the sea star Odontaster validus and the sea urchin Sterechinus neumayeri in Tethys Bay (Ross Sea, Antarctica)
Authors: Peirano Andrea , Bordone Andrea , Corgnati Lorenzo P. , Marini Simone 
Published: March 2023

AbstractOne-year time-lapse images acquired via an autonomous photo imaging device positioned at a depth of 20 m in Tethys Bay (Ross Sea, Antarctica) on a rocky bottom colonized by the sponge Mycale (Oxymycale) acerata were analysed. Monthly changes in the abundance and activity of the sea star Odontaster validus and sea urchin Sterechinus neumayeri on the sponge and nearby rocky bottom were compared with respect to environmental variables such as pack-ice presence/absence, temperature, salinity and photosynthetically active radiation. Sea urchins were more abundant on the rocky bottom and sponge during the summer and winter, respectively. Sea stars showed a decrease in the number of individuals on the sponge from January to December. The grazing activity of both species reached its maximum in January–April, when increased sunlight contributed to the phytoplankton bloom. The winter months were critical both for O. validus and S. neumayeri; although the red sea star maintained its pattern of activity on the rocky bottoms in terms of searching for food, the sea urchin reduced its activity. Time-lapse monitoring systems coupled with physicochemical sensors showed potential for revealing species behaviour in polar environments, contributing to the elucidation of future changes in coastal communities facing climate change.
Modeling Global Vegetation Gross Primary Productivity, Transpiration and Hyperspectral Canopy Radiative Transfer Simultaneously Using a Next Generation Land Surface Model—CliMA Land
Authors: Wang Y. , Braghiere R. K. , Longo M. , Norton A. J. , Köhler P. , Doughty R. , Yin Y. , Bloom A. A. , Frankenberg C. 
Published: March 2023

AbstractRecent progress in satellite observations has provided unprecedented opportunities to monitor vegetation activity at global scale. However, a major challenge in fully utilizing remotely sensed data to constrain land surface models (LSMs) lies in inconsistencies between simulated and observed quantities. For example, gross primary productivity (GPP) and transpiration (T) that traditional LSMs simulate are not directly measurable from space, although they can be inferred from spaceborne observations using assumptions that are inconsistent with those LSMs. In comparison, canopy reflectance and fluorescence spectra that satellites can detect are not modeled by traditional LSMs. To bridge these quantities, we presented an overview of the next generation land model developed within the Climate Modeling Alliance (CliMA), and simulated global GPP, T, and hyperspectral canopy radiative transfer (RT; 400–2,500 nm for reflectance, 640–850 nm for fluorescence) at hourly time step and 1° spatial resolution using CliMA Land. CliMA Land predicts vegetation indices and outgoing radiances, including solar‐induced chlorophyll fluorescence (SIF), normalized difference vegetation index (NDVI), enhanced vegetation index (EVI), and near infrared reflectance of vegetation (NIRv) for any given sun‐sensor geometry. The spatial patterns of modeled GPP, T, SIF, NDVI, EVI, and NIRv correlate significantly with existing data‐driven products (mean R2 = 0.777 for 9 products). CliMA Land would be also useful in high temporal resolution simulations, for example, providing insights into when GPP, SIF, and NIRv diverge.
Chronic Diseases Associated With Mortality in British Columbia, Canada During the 2021 Western North America Extreme Heat Event
Authors: Lee Michael Joseph , McLean Kathleen E. , Kuo Michael , Richardson Gregory R. A. , Henderson Sarah B. 
Published: March 2023

AbstractWestern North America experienced an unprecedented extreme heat event (EHE) in 2021, characterized by high temperatures and reduced air quality. There were approximately 740 excess deaths during the EHE in the province of British Columbia, making it one of the deadliest weather events in Canadian history. It is important to understand who is at risk of death during EHEs so that appropriate public health interventions can be developed. This study compares 1,614 deaths from 25 June to 02 July 2021 with 6,524 deaths on the same dates from 2012 to 2020 to examine differences in the prevalence of 26 chronic diseases between the two groups. Conditional logistic regression was used to estimate the odds ratio (OR) for each chronic disease, adjusted for age, sex, and all other diseases, and conditioned on geographic area. The OR [95% confidence interval] for schizophrenia among all EHE deaths was 3.07 [2.39, 3.94], and was larger than the ORs for other conditions. Chronic kidney disease and ischemic heart disease were also significantly increased among all EHE deaths, with ORs of 1.36 [1.18, 1.56] and 1.18 [1.00, 1.38], respectively. Chronic diseases associated with EHE mortality were somewhat different for deaths attributed to extreme heat, deaths with an unknown/pending cause, and non‐heat‐related deaths. Schizophrenia was the only condition associated with significantly increased odds of EHE mortality in all three subgroups. These results confirm the role of mental illness in EHE risk and provide further impetus for interventions that target specific groups of high‐risk individuals based on underlying chronic conditions.
Deriving Debris‐Flow Dynamics From Real‐Time Impact‐Force Measurements
Authors: Yan Yan , Tang Hui , Hu Kaiheng , Turowski Jens M. , Wei Fangqiang 
Published: March 2023

AbstractUnderstanding the impact forces exerted by debris flows is limited by a lack of direct field measurements and validated numerical models. In this study, we use real‐time impact‐force measurements and field observations of debris flows recorded by a sensor network in Jiangjia Ravine, China, to quantify the impact‐force distribution of natural debris flows. We observed one debris flow event during and after a storm on 25 August 2004, including 42 short‐duration surges and seven long‐duration surges, and impact‐force signals were successfully recorded for 38 surges. Our observed debris flows comprise high‐viscosity laminar flows with high sediment concentration and frequent solid‐to‐solid interactions. We identified a large magnitude (up to 1 kN), high‐frequency (greater than 1 Hz) fluctuating component of the impact force that we interpret as solid particle impact on the sensors. The variability of particle impact forces increases with the mean impact force. Our results show that a log‐logistic distribution can describe the probability density distribution of impact forces. Solid‐dominated surges and fluid‐dominated intersurge flows have similar impact‐force distributions, but surges usually have heavy tails. We created a dimensionless number to describe the impact force and correlated it against existing dimensionless parameters. Finally, we develop a simple particle impact model to understand the relationship between flow dynamics and the impact force inside debris flows that could be applied to improve debris‐flow flume experiments and design debris‐flow hazard mitigation measures.
A rare human variant that disrupts GPR10 signalling causes weight gain in mice
Authors: Talbot Fleur , Feetham Claire H. , Mokrosiński Jacek , Lawler Katherine , Keogh Julia M. , Henning Elana , Mendes de Oliveira Edson , Ayinampudi Vikram , Saeed Sadia , Bonnefond Amélie , Arslan Mohammed , Yeo Giles S. H. , Froguel Philippe , Bechtold David A. , Adamson Antony , Humphreys Neil , Barroso Inês , Luckman Simon M. , Farooqi I. Sadaf 
Published: March 2023

AbstractDisruption of brain-expressed G protein-coupled receptor-10 (GPR10) causes obesity in animals. Here, we identify multiple rare variants in GPR10 in people with severe obesity and in normal weight controls. These variants impair ligand binding and G protein-dependent signalling in cells. Transgenic mice harbouring a loss of function GPR10 variant found in an individual with obesity, gain excessive weight due to decreased energy expenditure rather than increased food intake. This evidence supports a role for GPR10 in human energy homeostasis. Therapeutic targeting of GPR10 may represent an effective weight-loss strategy.
Enhanced hybrid photocatalytic dry reforming using a phosphated Ni-CeO2 nanorod heterostructure
Authors: Tavasoli Alexandra , Gouda Abdelaziz , Zähringer Till , Li Young Feng , Quaid Humayra , Viasus Perez Camilo J. , Song Rui , Sain Mohini , Ozin Geoffrey 
Published: March 2023

AbstractOperating the dry reforming reaction photocatalytically presents an opportunity to produce commodity chemicals from two greenhouse gases, carbon dioxide and methane, however, the top-performing photocatalysts presented in the academic literature invariably rely on the use of precious metals. In this work, we demonstrate enhanced photocatalytic dry reforming performance through surface basicity modulation of a Ni-CeO2 photocatalyst by selectively phosphating the surface of the CeO2 nanorod support. An optimum phosphate content is observed, which leads to little photoactivity loss and carbon deposition over a 50-hour reaction period. The enhanced activity is attributed to the Lewis basic properties of the PO43− groups which improve CO2 adsorption and facilitate the formation of small nickel metal clusters on the support surface, as well as the mechanical stability of CePO4. A hybrid photochemical-photothermal reaction mechanism is demonstrated by analyzing the wavelength-dependent photocatalytic activities. The activities, turnover numbers, quantum efficiencies, and energy efficiencies are shown to be on par with other dry-reforming photocatalysts that use noble metals, representing a step forward in understanding how to stabilize ignoble nickel-based dry reforming photocatalysts. The challenges associated with comparing the performance of photocatalysts reported in the academic literature are also commented on.
Complexity of cortical wave patterns of the wake mouse cortex
Authors: Liang Yuqi , Liang Junhao , Song Chenchen , Liu Mianxin , Knöpfel Thomas , Gong Pulin , Zhou Changsong 
Published: March 2023

AbstractRich spatiotemporal dynamics of cortical activity, including complex and diverse wave patterns, have been identified during unconscious and conscious brain states. Yet, how these activity patterns emerge across different levels of wakefulness remain unclear. Here we study the evolution of wave patterns utilizing data from high spatiotemporal resolution optical voltage imaging of mice transitioning from barbiturate-induced anesthesia to wakefulness (N = 5) and awake mice (N = 4). We find that, as the brain transitions into wakefulness, there is a reduction in hemisphere-scale voltage waves, and an increase in local wave events and complexity. A neural mass model recapitulates the essential cellular-level features and shows how the dynamical competition between global and local spatiotemporal patterns and long-range connections can explain the experimental observations. These mechanisms possibly endow the awake cortex with enhanced integrative processing capabilities.
Structural basis of selective cannabinoid CB2 receptor activation
Authors: Li Xiaoting , Chang Hao , Bouma Jara , de Paus Laura V. , Mukhopadhyay Partha , Paloczi Janos , Mustafa Mohammed , van der Horst Cas , Kumar Sanjay Sunil , Wu Lijie , Yu Yanan , van den Berg Richard J. B. H. N. , Janssen Antonius P. A. , Lichtman Aron , Liu Zhi-Jie , Pacher Pal , van der Stelt Mario , Heitman Laura H. , Hua Tian 
Published: March 2023

AbstractCannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report the discovery of LEI-102, a CB2R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigate the selective CB2R activation by binding kinetics, site-directed mutagenesis, and cryo-EM studies. We identify key residues for CB2R activation. Highly lipophilic HU308 and the endocannabinoids, but not the more polar LEI-102, APD371, and CP55,940, reach the binding pocket through a membrane channel in TM1-TM7. Favorable physico-chemical properties of LEI-102 enable oral efficacy in a chemotherapy-induced nephropathy model. This study delineates the molecular mechanism of CB2R activation by selective agonists and highlights the role of lipophilicity in CB2R engagement. This may have implications for GPCR drug design and sheds light on their activation by endogenous ligands.
Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
Authors: Zhang Fangyuan , Qiu Fei , Zeng Junlan , Xu Zhichao , Tang Yueli , Zhao Tengfei , Gou Yuqin , Su Fei , Wang Shiyi , Sun Xiuli , Xue Zheyong , Wang Weixing , Yang Chunxian , Zeng Lingjiang , Lan Xiaozhong , Chen Min , Zhou Junhui , Liao Zhihua 
Published: March 2023

AbstractTropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted to certain species/tribes in this family. Little is known about the genomic basis and evolution of TAs biosynthesis and specialization in the Solanaceae. Here, we present chromosome-level genomes of two representative mTAs-producing species:Atropa belladonnaandDatura stramonium. Our results reveal that the two species employ a conserved biosynthetic pathway to produce mTAs despite being distantly related within the nightshade family. A conserved gene cluster combined with gene duplication underlies the wide distribution of TAs in this family. We also provide evidence that branching genes leading to mTAs likely have evolved in early ancestral Solanaceae species but have been lost in most of the lineages, withA. belladonnaandD. stramoniumbeing exceptions. Furthermore, we identify a cytochrome P450 that modifies hyoscyamine into norhyoscyamine. Our results provide a genomic basis for evolutionary insights into the biosynthesis of TAs in the Solanaceae and will be useful for biotechnological production of mTAs via synthetic biology approaches.
Revealing influencing factors on global waste distribution via deep-learning based dumpsite detection from satellite imagery
Authors: Sun Xian , Yin Dongshuo , Qin Fei , Yu Hongfeng , Lu Wanxuan , Yao Fanglong , He Qibin , Huang Xingliang , Yan Zhiyuan , Wang Peijin , Deng Chubo , Liu Nayu , Yang Yiran , Liang Wei , Wang Ruiping , Wang Cheng , Yokoya Naoto , Hänsch Ronny , Fu Kun 
Published: March 2023

AbstractWith the advancement of global civilisation, monitoring and managing dumpsites have become essential parts of environmental governance in various countries. Dumpsite locations are difficult to obtain in a timely manner by local government agencies and environmental groups. The World Bank shows that governments need to spend massive labour and economic costs to collect illegal dumpsites to implement management. Here we show that applying novel deep convolutional networks to high-resolution satellite images can provide an effective, efficient, and low-cost method to detect dumpsites. In sampled areas of 28 cities around the world, our model detects nearly 1000 dumpsites that appeared around 2021. This approach reduces the investigation time by more than 96.8% compared with the manual method. With this novel and powerful methodology, it is now capable of analysing the relationship between dumpsites and various social attributes on a global scale, temporally and spatially.
UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs
Authors: Hao Yue , Liu Haowen , Zeng Xian-Ting , Wang Ya , Zeng Wan-Xin , Qian Kang-Ying , Li Lei , Chi Ming-Xuan , Gao Shangbang , Hu Zhitao , Tong Xia-Jing 
Published: March 2023

AbstractDisturbed inhibitory synaptic transmission has functional impacts on neurodevelopmental and psychiatric disorders. An essential mechanism for modulating inhibitory synaptic transmission is alteration of the postsynaptic abundance of GABAARs, which are stabilized by postsynaptic scaffold proteins and recruited by presynaptic signals. However, how GABAergic neurons trigger signals to transsynaptically recruit GABAARs remains elusive. Here, we show that UNC-43/CaMKII functions at GABAergic neurons to recruit GABAARs and modulate inhibitory synaptic transmission at C. elegans neuromuscular junctions. We demonstrate that UNC-43 promotes presynaptic MADD-4B/Punctin secretion and NRX-1α/Neurexin surface delivery. Together, MADD-4B and NRX-1α recruit postsynaptic NLG-1/Neuroligin and stabilize GABAARs. Further, the excitation of GABAergic neurons potentiates the recruitment of NLG-1-stabilized-GABAARs, which depends on UNC-43, MADD-4B, and NRX-1. These data all support that UNC-43 triggers MADD-4B and NRX-1α, which act as anterograde signals to recruit postsynaptic GABAARs. Thus, our findings elucidate a mechanism for pre- and postsynaptic communication and inhibitory synaptic transmission and plasticity.
Evaluation of diverse soybean genotypes for seed longevity and its association with seed coat colour
Authors: T. V. Naflath , S. Rajendraprasad , R. L. Ravikumar 
Published: March 2023

AbstractSixty genotypes with different seed coat colour and seed sizes were evaluated for seed longevity under both natural and accelerated ageing over seasons. The genotypes were grown during rabi, 2018, and summer, 2021, and freshly harvested seeds were used. For natural ageing, seeds were stored in a cloth bag in ambient condition and were removed at bimonthly intervals till 20 months. Accelerated ageing was carried out as per International Seed Testing Association (ISTA) guidelines. The germination percentage after natural and accelerated ageing over two seasons was determined. The correlation between two seasons of accelerated ageing and month-wise natural ageing was highly significant. The principal component analysis (PCA) using seed longevity grouped the majority of black genotypes into a separate cluster. Higher seed longevity was associated with black seed coat colour and small seed size. Microsatellite marker-based clustering also produced a separate cluster for majority of black genotypes and grouped the genotypes into a large number of clusters suggesting high diversity in the plant material. Two black seed coat colour genotypes, ACC No.369 and ACC No.39 consistently showed higher longevity under natural and both the years of accelerated ageing and serve as a source of alleles for higher seed longevity in soybean.