bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wildlife policy, the food system and One Health: a complex systems analysis of unintended consequences for the prevention of emerging zoonoses in China, the Democratic Republic of the Congo and the Philippines
Authors: Clifford Astbury Chloe , Demeshko Anastassia , Aguilar Russel , Mapatano Mala Ali , Li Angran , Togño Kathleen Chelsea , Shi Zhilei , Wang Zhuoyu , Wu Cary , Yambayamba Marc K , Carabin Hélène , Clarke Janielle , De Leon Valentina , Desai Shital , Gallo-Cajiao Eduardo , Lee Kirsten Melissa , Sivapragasam Krishihan , Wiktorowicz Mary , Penney Tarra L 
Published: January 2025

IntroductionEvolving human–wildlife interactions have contributed to emerging zoonoses outbreaks, and pandemic prevention policy for wildlife management and conservation requires enhanced consideration from this perspective. However, the risk of unintended consequences is high. In this study, we aimed to assess how unrecognised complexity and system adaptation can lead to policy failure, and how these dynamics may impact zoonotic spillover risk and food system outcomes.MethodologyThis study focused on three countries: China, the Democratic Republic of the Congo (DRC) and the Philippines. We combined evidence from a rapid literature review with key informant interviews to develop causal loop diagrams (CLDs), a form of systems map representing causal theory about system factors and interconnections. We analysed these CLDs using the ‘fixes that fail’ (FTF) systems archetype, a conceptual tool used to understand and communicate how system adaptation can lead to policy failure. In each country, we situated the FTF in the wider system of disease ecology and food system factors to highlight how zoonotic risk and food system outcomes may be impacted.ResultsWe interviewed 104 participants and reviewed 303 documents. In each country, we identified a case of a policy with the potential to become an FTF: wildlife farming in China, the establishment of a new national park in the DRC, and international conservation agenda-setting in the Philippines. In each country, we highlighted context-specific impacts of the FTF on zoonotic spillover risk and key food system outcomes.ConclusionOur use of systems thinking highlights how system adaptation may undermine prevention policy aims, with a range of unintended consequences for food systems and human, animal and environmental health. A broader application of systems-informed policy design and evaluation could help identify instruments approporiate for the disruption of system traps and improve policy success. A One Health approach may also increase success by supporting collaboration, communication and trust among actors to imporove collective policy action.
Effectiveness of tobacco advertising, promotion and sponsorship bans on smoking prevalence, initiation and cessation: a systematic review and meta-analysis
Authors: Saad Christina , Cheng Brandon (Hsu-Chen) , Takamizawa Ryo , Thakur Arya , Lee Chae-Weon , Leung Lachlan , Veerman J Lennert , Aminde Leopold Ndemnge 
Published: January 2025

BackgroundBans on tobacco advertising, promotion and sponsorship (TAPS) have the potential to influence smoking behaviour. However, many countries are yet to implement such strategies.ObjectiveThis study aimed to synthesise contemporary evidence on the effectiveness of TAPS bans on smoking prevalence, initiation and cessation.Data sourcesMedline, EMBASE, Scopus, Cochrane Library and Web of Science databases were searched up to 11 April 2024. Sixteen eligible studies were included.Data selection and extractionTwo reviewers independently screened each study and extracted relevant data. Quality assessment was performed in duplicate using the ROBINS-I tool. Discrepancies were resolved via consensus or a third reviewer. Random effects meta-analyses were conducted for reasonably comparable studies.Data synthesisThe meta-analyses showed that TAPS bans were associated with a lower prevalence of current smoking (pooled OR= 0.80, 95% CI 0.68 to 0.95,I2=98.7%) and a reduced risk of smoking initiation (pooled HR=0.63, 95% CI 0.48 to 0.82,I2=95%). There was no association between TAPS bans and smoking cessation (pooled OR=1.10, 95% CI 0.86 to 1.40,I2=58.5%). Subgroup analyses revealed the effects of TAPS bans on smoking prevalence differed by duration of evaluation (p<0.01).ConclusionsThis review showed that TAPS bans were associated with a 20% lower odds of current smoking and a 37% reduced risk of smoking initiation. The available evidence suggests that TAPS bans influence smoking behaviour, which strengthens calls for the implementation and enforcement of these policies.
MPEG Column: 146th MPEG Meeting in Rennes, France
Authors: Timmerer Christian 
Published: January 2025

The 146th MPEG meeting was held in Rennes, France from 22-26 April 2024, and the official press release can be found here. It comprises the following highlights:
•AI-based Point Cloud Coding: Call for proposals focusing on AI-driven point cloud encoding for applications such as immersive experiences and autonomous driving.
•Object Wave Compression: Call for interest in object wave compression for enhancing computer holography transmission.
•Open Font Format: Committee Draft of the fifth edition, overcoming previous limitations like the 64K glyph encoding constraint.
•Scene Description: Ratified second edition, integrating immersive media objects and extending support for various data types.
•MPEG Immersive Video (MIV): New features in the second edition, enhancing the compression of immersive video content.
•Video Coding Standards: New editions of AVC, HEVC, and Video CICP, incorporating additional SEI messages and extended multiview profiles.
•Machine-Optimized Video Compression: Advancement in optimizing video encoders for machine analysis.
•MPEG-I Immersive Audio: Reached Committee Draft stage, supporting high-quality, real-time interactive audio rendering for VR/AR/MR.
•Video-based Dynamic Mesh Coding (V-DMC): Committee Draft status for efficiently storing and transmitting dynamic 3D content.
•LiDAR Coding: Enhanced efficiency and responsiveness in LiDAR data processing with the new standard reaching Committee Draft status.
Preparation of Photoluminescent Zr-Eu Compound Films Based on Electrodeposited 3D Zirconium Oxyfluoride Films
Authors: Chigane Masaya , Nakamura Masashi , Mitamura Koji , Watanabe Mitsuru , Watase Seiji 
Published: January 2025

Abstract
Photoluminescent europium-zirconium compound films were prepared by immersing electrodeposited 3D zirconium oxyfluoride films comprising aggregates of sword-type leaf-like units, in a europium nitrate aqueous solution at 323 K. Characterization of the as-immersed films using X-ray diffraction analysis and scanning transmission electron microscopy revealed the deposition of EuF3 on the surface of the leaf-like units. Analysis of the films calcined at 773 K in air employing Raman scattering spectroscopy suggested that the films were composed of rhombohedral EuOF and Eu3+-doped tetragonal ZrO2. The red photoluminescence of the films at room temperature originating from the 4f–4f transitions of Eu3+ was investigated in relation to the site symmetry of Eu3+ in the crystalline phase. The red photoluminescence properties of the films were improved by calcination, which intensified the peak of the 5D0 → 7F2 transition at ~610 nm, called as the electric dipole transition (EDT). The EDT emission intensity of the calcined films increased with increasing Eu3+ concentration in the immersion solution, which was attributed to the dominant crystalline growth of rhombohedral EuOF showing lower Eu3+ site symmetry compared with Eu3+-doped tetragonal ZrO2.
A Neighborhood-Level Hispanic Paradox: The Interaction among Hispanic Density, Neighborhood Disadvantage, and Survival in Patients with Breast Cancer
Authors: Hernandez Alexandra E. , Borowsky Peter A. , Nahodyl Lauren , Pinheiro Paulo S. , Kobetz Erin N. , Antoni Michael H. , Goel Neha 
Published: January 2025

Abstract

Background:
To evaluate the impact of Hispanic ethnic enclaves (EE) on the relationship between neighborhood disadvantage and overall survival in patients with breast cancer.

Methods:
Data from patients with stage I to IV breast cancer diagnosed between 2005 and 2017 were used to analyze the effects of area deprivation index (ADI) scores, a measure of neighborhood disadvantage, and census tract–level Hispanic density, a measure of EE, on overall survival using mixed-effects Cox regression models. The final model included the individual-level factors [age, income, race, Hispanic/Latino origin, nativity, insurance status, and comorbidities (hypertension, diabetes, and body mass index)] and clinical factors (National Comprehensive Cancer Network guideline–concordant treatment, stage, and receptor subtype).

Results:
A total of 5,387 patients were analyzed. Fifty-two percent resided in Hispanic EE. Enclave residents were predominantly White (93%), with Cubans the predominant subgroup (37%). Overall, there were 1,040 deaths within the cohort. Patients residing in highly disadvantaged neighborhoods (ADI tertile 3) within Hispanic EE experienced reduced HR compared with those outside of EE, evidenced by the interaction effect {EE × ADI tertile 3 − HR [95% confidence interval (CI)], 0.66 (0.44–0.98)}.

Conclusions:
Hispanic EE may protect against mortality in patients with breast cancer, suggesting that positive social factors help combat negative effects of neighborhood disadvantage for patients. Understanding the protective attributes of EE can help create effective cancer interventions and promote more equitable outcomes in minority populations.

Impact:
This study found that EE may protect against mortality in patients with breast cancer, suggesting that positive social factors may help mitigate the negative effects caused by the neighborhood.
FDA Approval Summary: Tovorafenib for Relapsed or Refractory BRAF-Altered Pediatric Low-Grade Glioma
Authors: Singh Sonia , Bradford Diana , Chatterjee Somak , Li Xiaoxue , Aungst Stephanie L. , Skinner Amy M. , Miller Claudia P. , Kim-McOlash Sarah , Fourie Zirkelbach Jeanne , Xiong Ye , Bi Youwei , Wang Ying-Hong , Yang Yuching , Sun Jielin , Kraft Jeffrey , Charlab Rosane , Shord Stacy S. , Tang Shenghui , Scepura Barbara , Bulatao Ilynn , Udoka Opeyemi , Saber Haleh , Rahman Nam Atiqur , Pazdur Richard , Singh Harpreet , Donoghue Martha , Drezner Nicole 
Published: January 2025

Abstract
On April 23, 2024, the FDA granted accelerated approval to tovorafenib, a type II RAF kinase inhibitor, for the treatment of patients 6 months of age and older with relapsed or refractory pediatric low-grade glioma (pLGG) harboring a BRAF fusion or rearrangement or BRAF V600 mutation. Efficacy was evaluated in FIREFLY-1 (NCT04775485), a single-arm, open-label, multicenter trial that enrolled patients 6 months to 25 years of age with relapsed or refractory pLGG with an activating BRAF alteration who had received prior systemic therapy. The major efficacy outcome measure was the radiologic overall response rate, defined as the proportion of patients with complete response, partial response, or minor response as determined by blinded independent central review using Response Assessment in Pediatric Neuro-Oncology criteria. A key secondary endpoint was duration of response. In an efficacy population of 76 patients, the overall response rate was 51% (95% confidence interval, 40–63), and the median duration of response was 13.8 months (95% confidence interval, 11.3–not estimable). The required postmarketing clinical trial (FIREFLY-2) was well underway at the time of accelerated approval. This represents the first FDA approval of a systemic therapy for the treatment of patients with pLGG with BRAF fusions or rearrangements.
Stanniocalcin 1 in Patients with Refractory Colorectal Cancer Treated with Regorafenib: A Post Hoc Biomarker Analysis of the TEXCAN and CORRECT Trials
Authors: Vienot Angélique , Vernerey Dewi , Bouard Adeline , Klajer Elodie , Kim Stefano , Tournigand Christophe , Louvet Christophe , André Thierry , Rousseau Benoît , Wespiser Mylène , Spehner Laurie , Wang Ying A. , Weispfenning Anke , Dochy Emmanuelle , Borg Christophe 
Published: January 2025

Abstract
Biomarkers for antiangiogenic drugs in chemorefractory metastatic colorectal cancer (mCRC) are lacking. We investigated the relationship between stanniocalcin 1 (STC1) and outcomes in patients treated with regorafenib in the TEXCAN and CORRECT trials. Baseline plasma STC1 protein levels were measured by ELISA from patients with chemorefractory mCRC enrolled in TEXCAN (regorafenib n = 48) and CORRECT (placebo n = 211; regorafenib n = 435). The relationship between STC1 levels and overall survival (OS) was assessed using a Cox proportional hazards model. The median STC1 value was increased in patients with chemorefractory mCRC (1,211 pg/mL) compared with previously untreated patients (215 pg/mL). Using an optimized cut-off, STC1 was prognostic for OS [HR = 2.12, 95% confidence interval (CI), 1.79–2.50; P &lt; 0.001], with a median OS of 7.63 months in the STC1-low group (&lt;1,436.87 pg/mL; n = 400) and 3.81 months in the STC1-high group (≥1,436.87 pg/mL; n = 246). The interaction P value of lactate dehydrogenase and treatment revealed no predictive effect of lactate dehydrogenase levels on OS in terms of regorafenib (P = 0.598). A predictive analysis suggested a significant association between STC1 and regorafenib for OS (interaction P = 0.049). The median OS with regorafenib versus placebo was 8.32 versus 6.54 months in the STC1-low group (HR = 0.83, 95% CI, 0.66–1.03; P = 0.087) and 4.41 versus 3.09 months in the STC1-high group (HR = 0.64, 95% CI, 0.49–0.84; P = 0.001). Altogether, high STC1 protein levels have a predictive potential to characterize a population of patients with chemorefractory mCRC and poor prognosis in whom regorafenib has an increased level of efficacy.

Significance:
STC1 is a protein secreted by intratumor endothelial cells in which plasma concentrations increase in patients with chemorefractory mCRC. Based on analyses of patients with refractory mCRC in the TEXCAN and CORRECT trials, we found that STC1 plasma levels had a prognostic role for OS, with high levels associated with poor outcome. A predictive role for baseline STC1 levels was pointed out for regorafenib efficacy.
Passions à bas bruit. Chroniques de l’attente numérique
Authors: Bertin Éric 
Published: January 2025

Cet article vise à mettre à l’épreuve l’héritage greimassien de l’étude des passions, inaugurée dans le texte « De la colère » (Greimas, 1983, p. 225-245). On postule qu’il est possible de rechercher les traces et les modalités d’un processus de pathémisation des requêtes numériques, sous-jacentes à un matériau discursif essentiellement descriptif. C’est la notion d’attente numérique qui est au cœur du processus de pathémisation. C’est d’abord la « fenêtre d’attente » du moteur de recherche, en tant que composante médiatique, qui conditionne la disposition passionnelle du sujet numérique. C’est ensuite la reconnaissance de présuppositions modales, sous-jacentes aux requêtes, qui autorise à saisir les traces de la disposition affective de l’utilisateur. Enfin, la notion de schéma d’attente permet d’identifier sept schémas d’attente affectifs dominants, qui confirment bien l’emprise de la sensibilisation sur le sujet de l’attente numérique.
Duas (ou mais) questões sobre artes plásticas, crença e verdade
Authors: Teixeira Lucia 
Published: January 2025

This article discusses two experiences involving the appreciation and valuation of plastic objects, relating them to the fiduciary contract established between the instances of production and reception of art — the attribution of authorship to a work and the curation of an exhibition. In the first case, the value of a signature is analyzed as a market and aesthetic gesture, and in the second, the scene of an exhibition of abstract paintings and figurative sculptures, which, by generating aesthetic effects and media repercussions, thematizes the problem of representation. In both cases, the main theoretical issue is the relationship between belief and truth in the field of plastic arts, based on Discursive Semiotics, particularly two chapters from A. J. Greimas’ book Du sens II, 'The Contract of Veridiction' and 'Knowing and Believing: a Single Cognitive Universe'.
Determinants of Racial and Ethnic Differences in Maternal Cardiovascular Health in Early Pregnancy
Authors: Cameron Natalie A. , Huang Xiaoning , Petito Lucia C. , Ning Hongyan , Shah Nilay S. , Yee Lynn M. , Perak Amanda M. , Haas David M. , Mercer Brian M. , Parry Samuel , Saade George R. , Silver Robert M. , Simhan Hyagriv N. , Reddy Uma M. , Varagic Jasmina , Licon Ernesto , Greenland Philip , Lloyd-Jones Donald M. , Kershaw Kiarri N. , Grobman William A. , Khan Sadiya S. 
Published: January 2025

BACKGROUND:
Suboptimal cardiovascular health (CVH) in pregnancy is associated with adverse maternal and offspring outcomes. To guide public health efforts to reduce disparities in maternal CVH, we determined the contribution of individual- and neighborhood-level factors to racial and ethnic differences in early pregnancy CVH.

METHODS:
We included nulliparous individuals with singleton pregnancies who self-identified as Hispanic, non-Hispanic Black (NHB), or non-Hispanic White (NHW) and participated in the nuMoM2b cohort study (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be). First-trimester CVH was quantified using 6 routinely assessed factors in pregnancy included in the American Heart Association Life’s Essential 8 score (0–100 points), in which higher scores indicate better CVH. Oaxaca-Blinder decomposition evaluated the extent to which racial and ethnic differences in CVH were explained by differences in individual- and neighborhood-level factors (age, socioeconomic characteristics, psychosocial factors, nativity, perceived racial discrimination, and area deprivation index).

RESULTS:

Among 9104 participants, the mean age was 26.8 years, 18.7% identified as Hispanic, 15.6% identified as NHB, and 65.8% identified as NHW. Mean (SD) CVH scores were 76.7 (14.1), 69.8 (15.1), and 79.9 (14.3) in the Hispanic, NHB, and NHW groups, respectively (
P
<0.01). The individual- and neighborhood-level factors evaluated explained all differences in CVH between Hispanic and NHW groups and 82% of differences between NHW and NHB groups. Racial and ethnic differences in educational attainment explained the greatest proportion of differences in CVH. If mean years of education among the Hispanic (14.0 [2.5]) and NHB (13.4 [2.4]) groups were the same as the NHW (15.8 [2.4]) group, mean CVH scores would be higher by 2.98 points (95% CI, 2.59–3.37) in the Hispanic and 4.28 points (95% CI, 3.77–4.80) in NHB groups.

CONCLUSIONS:
Racial and ethnic differences in early pregnancy CVH were largely explained by differences in individual- and neighborhood-level factors.
Impact of Frailty on Antihypertensive Treatment in Older Adults
Authors: Chen Linan , You Shoujiang , Ee Nicole , Rockwood Kenneth , Ward David D. , Woodward Mark , Liu Tao , Gao Yijie , Williamson Jeff D. , Anderson Craig S. , Harris Katie , Chen Xiaoying , Peters Ruth 
Published: January 2025

BACKGROUND:
The association between systolic blood pressure and all-cause mortality differs between frail and nonfrail individuals, highlighting uncertainties about the effectiveness of antihypertensive treatments in frail populations.

METHODS:
Using data from the SHEP trial (Systolic Hypertension in the Elderly Program), a baseline frailty index (FI), including 55 variables, was constructed. Fine-Gray subdistribution hazard models and Cox proportional hazards regression models were used to explore the association between baseline FI and the risks of stroke, cardiovascular disease, and all-cause death, as well as to examine whether the impact of antihypertensive treatment on these outcomes was modified by baseline FI.

RESULTS:

A total of 4692 participants (mean age, 72.1 years; 56.7% women) were included, with a mean (SD) FI of 0.134 (0.061). During a median follow-up period of 4.4 years, FI was associated with a higher risk of stroke (subdistribution hazard ratio, 1.24 [95% CI, 1.10–1.39]; per SD higher FI), cardiovascular disease (subdistribution hazard ratio, 1.18 [95% CI, 1.09–1.26]), and all-cause death (hazard ratio, 1.37 [95% CI, 1.26–1.50]), after adjustment for age, sex, race, education and treatment group. Although those with higher levels of frailty were at higher risk for all outcomes, there was no evidence of an interaction between baseline FI and antihypertensive treatment (
P
for interaction >0.05 for all outcomes).

CONCLUSIONS:
In individuals with isolated systolic hypertension, antihypertensive treatment improved associated outcomes even among those with a higher degree of frailty. These findings from the SHEP trial reinforce evidence from other seminal antihypertensive trials, which collectively inform the appropriate treatment of frail individuals with hypertension.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT00000514.
Usefulness of Myelin Quantification Using Synthetic Magnetic Resonance Imaging for Predicting Outcomes in Patients With Acute Ischemic Stroke
Authors: Toko Megumi , Nezu Tomohisa , Eto Futoshi , Aoki Shiro , Ohshita Tomohiko , Ueno Hiroki , Akiyama Yuji , Maruyama Hirofumi 
Published: January 2025

BACKGROUND:
Synthetic magnetic resonance imaging (MRI) is an innovative MRI technology that enables the acquisition of multiple quantitative values, including T1 and T2 values, proton density, and myelin volume, in a single scan. Although the usefulness of myelin measurement with synthetic MRI has been reported for assessing several diseases, investigations in patients with stroke have not been reported. We aimed to explore the utility of myelin quantification using synthetic MRI in predicting outcomes in patients with acute ischemic stroke.

METHODS:
Patients with acute ischemic stroke (n=101) with a premorbid modified Rankin Scale score ≤2 were enrolled. We performed MRI with a 3 T scanner, acquiring synthetic MRI data in addition to data acquired using the routine protocol; we measured total myelin volume (TMV) using synthetic MRI software. After hospitalization, a synthetic MRI was performed when the patient’s condition was stable, with a median of 7 days from onset to MRI. We examined the factors related to good stroke outcomes (defined by a modified Rankin Scale score of ≤2 at 3 months).

RESULTS:

Patients with larger TMV were younger, were more frequently male, and had higher body mass index. In addition, TMV was associated with the severity of white matter hyperintensities and total small vessel burden scores. The patients with good outcomes (n=66) had larger TMVs than those without (144.85±22.19 versus 126.62±21.81 mL,
P
<0.001). Multivariable analysis revealed that the TMV quartiles were independently associated with good functional outcomes (odds ratio, 2.54 [95% CI, 1.12–6.70];
P
=0.025) after adjusting for baseline clinical characteristics including initial stroke severity, acute brain infarct volume, and brain parenchymal volume.

CONCLUSIONS:
A large TMV quantified using synthetic MRI was independently associated with good functional outcomes after adjusting for several confounding factors. TMV, which suggests the validity of myelin quantification, might be a useful indicator for predicting stroke outcomes.